gebhart/patrepeval huggingface dataset:
A peak power reduction method for multicarrier transmission (2002)

We developed a method to reduce peak to average power-ratio (PAR) of multicarrier signals. The method enlarged the quadrature amplitude modulation (QAM) constellation size at a number of tones so that several signal points represent the same information. It chose a signal point among equivalent signal points that minimized PAR. This method achieved more than 4 dB PAR reduction when 64 QAM was used to represent 16 QAM constellation in a 64-subcarrier system. Also we could trade the PAR reduction for complexity and power increase by changing the size of the extended constellation.
The importance of the N–H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines (2011)

Ru(II) complexes of TsDPEN containing two alkyl groups on the non-tosylated nitrogen atom are poor catalysts for asymmetric transfer hydrogenation of ketones and imines; this observation provides direct evidence for the importance of the N-H interaction in the transition state for ketone reduction.
Bee Venom Promotes Hair Growth in Association with Inhibiting 5α-Reductase Expression (2016)

Alopecia is an important issue that can occur in people of all ages. Recent studies show that bee venom can be used to treat certain diseases including rheumatoid arthritis, neuralgia, and multiple sclerosis. In this study, we investigated the preventive effect of bee venom on alopecia, which was measured by applying bee venom (0.001, 0.005, 0.01%) or minoxidil (2%) as a positive control to the dorsal skin of female C57BL/6 mice for 19 d. Growth factors responsible for hair growth were analyzed by quantitative real-time PCR and Western blot analysis using mice skins and human dermal papilla cells (hDPCs). Bee venom promoted hair growth and inhibited transition from the anagen to catagen phase. In both anagen phase mice and dexamethasone-induced catagen phase mice, hair growth was increased dose dependently compared with controls. Bee venom inhibited the expression of SRD5A2, which encodes a type II 5α-reductase that plays a major role in the conversion of testosterone into dihydrotestosterone. Moreover, bee venom stimulated proliferation of hDPCs and several growth factors (insulin-like growth factor 1 receptor (IGF-1R), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)2 and 7) in bee venom-treated hDPCs dose dependently compared with the control group. In conclusion, bee venom is a potentially potent 5α-reductase inhibitor and hair growth promoter.
Bisphosphonate Therapy in Fibrous Dysplasia (2001)

Fibrous dysplasia is proliferation of fibrous tissue within the bone marrow causing osteolytic lesions and pathologic fractures. Recently, second generation bisphosphonates have shown promise in the treatment of patients with fibrous dysplasia. In the current study, six patients with fibrous dysplasia were treated with either oral alone or oral and intravenous bisphosphonates. The participants were observed for changes in N-telopeptide, pain score, and radiographic changes. In the current study, the combination bisphosphonate therapy diminished pain, prevented fractures, lowered N-telopeptide values, and led to partial resolution of fibrous dysplasia lesions.
500 W continuous-wave fibre laser with excellent beam quality (2003)

Power scaling of continuous-wave fibre lasers with up to 0.5 kW output powers from a single fibre with nearly diffraction-limited beam quality without the limitation of nonlinear effects is reported.
Caspase-3 Gene Silencing for Inhibiting Apoptosis in Insulinoma Cells and Human Islets (2008)

Although islet transplantation has great potential to treat type I diabetes, most islet grafts do not function due to the host immune rejection, nonspecific inflammatory response and poor revascularization. Since caspase-3 plays a crucial role in apoptosis of transplanted islet cells, we used chemically synthesized small interfering RNAs (siRNAs) to silence caspase-3 in insulinoma (INS-1E) cells and human islets, and then determined whether caspase-3 gene silencing can prevent these cells from cytokine-induced apoptosis. Transfection of INS-1E cells and islets with siRNAs reduced caspase-3 transcripts by 50-67% and 50%, respectively. Additionally, apoptosis in transfected insulinoma cells was markedly inhibited. Since gene silencing did not last beyond two days, we converted potent siRNA into shRNA and constructed replication deficient adenoviral (Adv) vectors encoding these shRNAs driven by a U6 or H1 promoter. Compared to chemically synthesized siRNA, Adv-caspase-3-shRNA efficiently transduced islets, showed relatively higher and prolonged levels of gene silencing beyond five days, with higher gene silencing with a U6 promoter, and protected islets from cytokine-induced apoptosis. Finally, return to normoglycemia was achieved at 1 day post-transplantation of Adv-caspase-3-shRNA transduced islets under the kidney capsules of streptozotocin induced nonobese diabetic-severe combined immunodeficiency (NOD-SCID) mice and maintained beyond two weeks. Blood glucose levels returned to > or = 325 mg/dL upon removal of the islet graft-bearing kidney at 32 days after transplantation, confirming that transplanted islets were functional.
Cardiac CaM Kinase II Genes δ and γ Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy (2014)

We established a mouse model in which CaMKII's activity is specifically and completely abolished. By the use of this model we show that CaMKII induces maladaptive cardiac remodeling while it inhibits calcineurin-dependent hypertrophy. These data suggest inhibition of CaMKII but not calcineurin as a promising approach to attenuate the progression of heart failure.
Community Detection with Graph Neural Networks (2017)

We study data-driven methods for community detection in graphs. This estimation problem is typically formulated in terms of the spectrum of certain operators, as well as via posterior inference under certain probabilistic graphical models. Focusing on random graph families such as the Stochastic Block Model, recent research has unified these two approaches, and identified both statistical and computational signal-to-noise detection thresholds. 
We embed the resulting class of algorithms within a generic family of graph neural networks and show that they can reach those detection thresholds in a purely data-driven manner, without access to the underlying generative models and with no parameter assumptions. The resulting model is also tested on real datasets, requiring less computational steps and performing significantly better than rigid parametric models.
Design and completion of digital certificate with authorization based on PKI (2005)

In this paper, a design and establishment of certification authority is completed successfully, and the functions of digital certificate are extended through describing and encoding the role attribute extension of particular certificate using ASN.1. When issuing a certificate for user, it is appended to user's certificate that some access privilege coming from RBAC database. Consequently, differing from general certificate, this special certificate cannot only be used to identify the holder, but also can control his access to some object resources. At last, the prospect of digital certificate with authorization based on PKI (public key infrastructure) is revealed.
C-erbB-2 protein and neuroendocrine expression in breast carcinomas. (1991)

90 primary breast carcinomas and 18 metastases were immunostained for c-erbB-2 protein and neuron specific enolase. 30 tumours were c-erbB-2 negative and NSE positive, 23 tumours were NSE negative and c-erbB-2 positive. 1 tumour expressed focal immunoreactivity for both markers. 54 of the 108 tumours (50%) did not express either marker. Hormone immunoreactivity was present in single cells and in small groups of cells in 18 of the 31 NSE positive tumours. Bombesin, neurotensin and prealbumin were present in 4 cases each, followed by beta-endorphin and VIP in 3 cases each, leu-enkephalin in 2 cases and gastrin, serotonin, substance P, glucagon and somatostatin in 1 case each. None of 10 NSE negative breast carcinomas were comprised of cells expressing immunoreactivity for hormones. By immunoelectron microscopic examination the c-erbB-2 protein was shown to be present on the cell membrane, on smooth areas, microvilli and in coated pits. Immunoreactivity was also expressed in vesicles in cytoplasm and along rough endoplasmic reticulum. The study shows that c-erbB-2 protein expression and neuroendocrine activity are present in different tumour cell populations. This supports the hypothesis that the presence of c-erbB-2 protein, indicating an elevated cellular tyrosine kinase activity with stimulation of growth, intracellular Ca++, and phosphatidylinositol derivates, means that the same cell does not need regulation of the same factors by stimulation of peptide hormone receptors. Thus the production of autocrine and paracrine factors is switched off.
Network intrusion detection using word embeddings (2017)

Word embeddings, learning syntactic and semantic relationships between words from the raw text, are known to achieve superior performance in many prediction and classification tasks. In this paper, we aim to show how word embedding techniques can work on a high number of nontextual data, thus has new applicability in cyber security. Specifically, we build neural embeddings with a large amount of network log data (KDD CUP'99 dataset) and train several classification models using the learned neural embeddings. Our experiment results demonstrate that the vector representations successfully learn useful features from non-textual data, similar to how classic word embeddings do with natural language and can achieve a high F1 score for both binary (normal vs. abnormal) and multi-class (DOS, Probe, U2R, R2L, and normal) classifications. We also demonstrate that the classification algorithms using the embedded vectors can maintain fairly high accuracy even when training data is very small.
Novel ZnO-binding peptides obtained by the screening of a phage display peptide library (2012)

Zinc oxide (ZnO) is a semiconductor compound with a potential for wide use in various applications, including biomaterials and biosensors, particularly as nanoparticles (the size range of ZnO nanoparticles is from 2 to 100 nm, with an average of about 35 nm). Here, we report isolation of novel ZnO-binding peptides, by screening of a phage display library. Interestingly, amino acid sequences of the ZnO-binding peptides reported in this paper and those described previously are significantly different. This suggests that there is a high variability in sequences of peptides which can bind particular inorganic molecules, indicating that different approaches may lead to discovery of different peptides of generally the same activity (e.g., binding of ZnO) but having various detailed properties, perhaps crucial under specific conditions of different applications.
Activation of Protein C by Arginine-Specific Cysteine Proteinases (Gingipains-R) from Porphyromonas gingivalis (1999)

In order to determine the effect of bacterial proteinases on activation of the protein C system, a negative regulator of blood coagulation, two arginine-specific cysteine proteinases (gingipains R) from Porphyromonas gingivalis, a causative bacterium of adult periodontitis, were examined. Each enzyme activated human protein C in a dose- and incubation time-dependent manner. Interestingly, the form of enzyme being composed of a non-covalent complex containing both catalytic and adhesion domains (RgpA) produced activated protein C 14-fold more efficiently than RgpB which contained the catalytic domain alone. The kcat/Km value of RgpA was 18-fold higher than that of RgpB and comparable to that of the thrombin-thrombomodulin complex, the physiological activator of protein C. RgpA catalyzed protein C activation was augmented 1.4-fold by phospholipids, ubiquitous cell membrane components. Furthermore, RgpA, but not RgpB, could activate protein C in plasma and this resulted in a decrease of the protein C concentration in plasma, which is often observed in patients with sepsis during the development of disseminated intravascular coagulation (DIC). These data indicate that RgpA is a more potent activator of protein C than RgpB and suggest that only the former enzyme can cause protein C activation in vivo. The present study further suggests that bacterial proteinases may possibly contribute to the consumption of plasma protein C which predisposes to DIC and/or promotes a thrombotic tendency towards DIC in sepsis.
Applications of Chrominance Vector Quantization to Intraframe and Interframe Compression of Colour Video Sequences (2001)

A video compression technique for applications in very low bit rate coding is presented. The technique ...
Secretion in yeast of mutant human lysozymes with and without glutathione bound to cysteine 95. (1990)

A mutant human lysozyme C77A, in which Cys-77 is replaced with Ala, was secreted by Saccharomyces cerevisiae as two proteins (C77A-a and C77A-b) with different specific activities. A peptide fragment from Val93 to Ala108 was obtained from C77A-a by pepsin digestion, and examined by fast atom bombardment mass spectrometry and amino acid analysis. The results showed that glutathione was attached to the thiol group of Cys95 of the fragment through a disulfide linkage. This observation was confirmed by quantitative formation of free glutathionesulfonic acid from C77A-a by performic acid treatment. In contrast, there was no modification in the case of C77A-b. These results indicate that C77A-a contained a mixed disulfide with glutathione attached to cysteine residue 95. In C77A-b, there appears to be a free thiol of Cys95 surrounded by many side chains, which was not modified by iodoacetic acid under native conditions, suggesting that the attachment of glutathione occurs during folding. These findings further suggest that in the oxidation step of disulfide bond formation in human lysozyme secreted by yeast, mixed disulfides are formed with glutathione and that posttranslational modification with glutathione can occur even in a protein secreted by yeast.
Large Scale Image Retrieval in Urban Environments with Pixel Accurate Image Tagging (2011)

Abstract : City-scale image retrieval and tagging is an important problem with many applications in localization and augmented reality. The basic idea is to match a user generated query image against a database of tagged images. Once a correct match is retrieved, pose information associated with the retrieved image can be used to augment the query image. In this report we describe an approach to large scale image retrieval in urban environment by taking advantage of coarse position estimates available on many mobile devices today e.g. via GPS or cell tower triangulation. By partitioning the large image database for a given geographic region into a number of overlapping cells each with its own prebuilt search and retrieval structure, we avoid the performance degradation faced by many cityscale retrieval systems. Typically, both retrieval speed and retrieval accuracy decreases as the size of the database grows. Once a correct image match is found, a set of point to point correspondences between query and retrieved image is used to compute a homography transformation which can then be used to transfer tag information associated with points in the database image onto the query image with near pixel-level accuracy. An example of a tagged query outputted by our system and its corresponding database match is shown in Figure 1. We demonstrate retrieval results over a 12,000 image database covering a 1 km2 area of downtown Berkeley and illustrate tag transfer results over the same dataset.
Predictive Inequity in Object Detection (2019)

In this work, we investigate whether state-of-the-art object detection systems have equitable predictive performance on pedestrians with different skin tones. This work is motivated by many recent examples of ML and vision systems displaying higher error rates for certain demographic groups than others. We annotate an existing large scale dataset which contains pedestrians, BDD100K, with Fitzpatrick skin tones in ranges [1-3] or [4-6]. We then provide an in-depth comparative analysis of performance between these two skin tone groupings, finding that neither time of day nor occlusion explain this behavior, suggesting this disparity is not merely the result of pedestrians in the 4-6 range appearing in more difficult scenes for detection. We investigate to what extent time of day, occlusion, and reweighting the supervised loss during training affect this predictive bias.
Real-world study for the optimal charging of electric vehicles (2020)

Electric Vehicles (EVs), accompanied with the use of Renewable Energy Sources (RES), are the solution for the decarbonization of the transport sector and are undoubtedly on the rise. Although EVs have been in the limelight over the last decade, little effort has been made towards the proper use of the vehicle’s battery. Therefore, a better understanding of Lithium-ion (Li-ion) batteries, since they represent the heart of the majority of electric cars, during the discharging and charging procedure is crucial. The present study, that was experimentally conducted under real-world driving conditions, quantitatively analyzes the energy losses that take place during the charging of a Battery Electric Vehicle (BEV), focusing especially in the previously unexplored 80%–100% State of Charge (SoC) area. The results show that losses, during charging within the abovementioned area, are almost double compared to the 20%–80% SoC area and vehicle’s average specific real energy consumption is almost 2 kWh/100 km more, compared to what the driver sees on the EV’s dashboard. Furthermore, it is not for the driver’s benefit to exceed 80% of SoC during charging, considering the required charging time, the distance that each SoC area provides and the life expectancy of the battery itself. Based on these results and after a thorough literature review, the authors suggest the optimum SoC range within which drivers should operate the EV’s battery.
Regionally Adaptive Histogram Equalization of the Chest (1987)

Advances in the area of digital chest radiography have resulted in the acquisition of high-quality images of the human chest. With these advances, there arises a genuine need for image processing algorithms specific to the chest, in order to fully exploit this digital technology. We have implemented the well-known technique of histogram equalization, noting the problems encountered when it is adapted to chest images. These problems have been successfully solved with our regionally adaptive histogram equalization method. With this technique histograms are calculated locally and then modified according to both the mean pixel value of that region as well as certain characteristics of the cumulative distribution function. This process, which has allowed certain regions of the chest radiograph to be enhanced differentially, may also have broader implications for other image processing tasks.
A phase 1 study of a heterologous prime-boost vaccination involving a truncated HER2 sequence in patients with HER2-expressing breast cancer (2015)

A phase 1 clinical trial was conducted to assess the safety, tolerability, and preliminary efficacy of a heterologous prime-boost strategy involving plasmid DNA (pHM-GM-CSF, expressing truncated human epidermal growth factor receptor 2 (HER2) and granulocyte macrophage colony-stimulation factor (GM-CSF) as a bicistronic message) and an adenoviral vector (Ad-HM, containing the same modified HER2 sequence only), in patients with stage III-IV metastatic breast cancer expressing HER2. Nine eligible subjects were divided into three cohorts based on the dosages (2, 4, and 8 mg/patient/visit) of pHM-GM-CSF used as the primer, which was intramuscularly injected three times at weeks 0, 2, and 4. It was followed by a single injection of Ad-HM (3 × 10(9) virus particles), used as a booster, at week 6. During the 6-month follow-up period, adverse events (AEs), pharmacokinetics and pharmacodynamics, and HER2-specific cellular and humoral immune responses were evaluated. Seven cases of minor grade 1 toxicities in four of nine subjects and no serious drug-related AEs were reported. HER2-specific cell-mediated or humoral immunity was produced in all (100%) or three subjects (33%), respectively. One subject showed a partial response, and seven subjects had stable diseases. However, there were no differences in clinical tumor response and HER2-specific immune responses among the cohorts. These results showed that intramuscular injections of pHM-GM-CSF and Ad-HM were well tolerated and safe.
Measuring P700 Absorbance Changes around 830 nm with a New Type of Pulse Modulation System (1988)

Abstract A new measuring system for monitoring absorbance changes around 830 n m is described, which was developed by modification of a commercially available pulse modulation fluorometer. All modifications concern the emitter-detector unit of the fluorometer, such that only this unit needs to be exchanged when changing from fluorescence to absorbance measurements and vice versa. The new system is shown to be well-suited for measuring redox changes of P700, the reaction center of photosystem I, in intact leaves and isolated chloroplasts. The observed kinetic changes at 830 nm in response to single turnover or multiple turnover saturating flashes are practically identical to those previously measured around 700 nm . The signal/noise ratio is sufficiently high to give well-resolved kinetics without signal averaging. W h e n P700 is oxidized by far-red background light, valuable information on the state of the intersystem electron transport chain is given by the re-reduction kinetics induced by single or multiple turnover saturating flashes. Such measurements are facilitated by the use of poly-furcated fiberoptics. With intact leaves, almost identical responses are found when measuring through the leaf (transmission mode) or from the leaf surface (remission mode). Modulated chlorophyll fluorescence can be measured in parallel; application of saturation pulses for fluorescence quenching analysis produces transient P700 oxidation without oversaturating the measuring system. The information on the P700 redox state complements that obtained from fluorescence measurements, yielding a new practical tool in plant physiological research.
Malignant rabbit fibroma virus causes secondary immunosuppression in rabbits. (1983)

Shope fibroma virus (SFV) causes a localized, self-limited, fibroblastic proliferation in adult rabbits. Extracts of Shope fibroma tumors were found to contain a second virus that induces a rapidly progressive disseminated tumor. Dissemination of this malignant fibroma is associated with activation of commensal mucosal infection with Pasteurella multocida, causing purulent conjunctivitis and rhinitis and resulting in death from nasal obstruction. We have isolated this new agent by two cycles of plaque purification. It is a poxvirus that is antigenically virtually identical to SFV as measured by a plaque reduction assay, but behaves differently both in vivo and in vitro. We have called this virus malignant rabbit fibroma virus (MV). Electrophoresis of restriction digests made with HIND III indicates that despite the antigenic similarity of SFV and MV, the locations of HIND III sites in the two viral genomes are quite different. These experiments have enabled us to determine that MV was present in small quantities in our initial uncloned stock of Patuxent strain SFV. Lymphocytes from rabbits bearing MV-induced tumors responded poorly to both B and T lymphocyte mitogens. This nonspecific immunologic dysfunction is evident at or before the time when metastases and Gram-negative infection develop, and it becomes more profound as the disease progresses. MV-induced tumors may provide a model for Gram-negative infection and decreased immunologic responsiveness associated with malignancies.