gebhart/patrepeval huggingface dataset:
[The study on the characteristics and particle densities of lightning discharge plasma]. (2008)

According to the wavelengths, relative intensities and transition parameters of lines in cloud-to-ground lightning spectra obtained by a slit-less spectrograph in Qinghai province and Xizang municipality, and by theoretical calculations of plasma, the average temperature and electron density for individual lightning discharge channel were calculated, and then, using Saha equations, electric charge conservation equations and particle conservation equations, the particle densities of every ionized-state, the mass density, pressure and the average ionization degree were obtained. Moreover, the average ionization degree and characteristics of particle distributions in each lightning discharge channel were analyzed. Local thermodynamic equilibrium and an optically thin emitting gas were assumed in the calculations. The result shows that the characteristics of lightning discharge plasma have strong relationships with lightning intensities. For a certain return stroke channel, both temperatures and electron densities of different positions show tiny trend of falling away with increasing height along the discharge channel. Lightning channels are almost completely ionized, and the first ionized particles occupy the main station while N II has the highest particle density. On the other hand, the relative concentrations of N II and O II are near a constant in lightning channels with different intensities. Generally speaking, the more intense the lightning discharge, the higher are the values of channel temperature, electron density and relative concentrations of highly ionized particles, but the lower the concentration of the neutral atoms. After considering the Coulomb interactions between positive and negative particles in the calculations, the results of ionization energies decrease, and the particle densities of atoms and first ionized ions become low while high-ionized ions become high. At a temperature of 28000 K, the pressure of the discharge channel due to electrons, atoms and ions is about 10 atmospheric pressure, and it changes for different lightning stroke with different intensity. The mass density of channel is lower and changes from 0.01 to 0.1 compared to the mass density of air at standard temperature and pressure (STP).
Skp2 and p27<sup>kip1</sup> expression in melanocytic nevi and melanoma: an inverse relationship* (2004)

Gain of Skp2 and loss of p27kip1 protein expression are implicated in melanoma progression where the level of p27kip1 may be regulated by targeted proteolysis via Skp2. Cytoplasmic expression of Skp2 defines a subset of aggressive melanomas and could represent another pathway of deregulation of the cell cycle.
<title>Return-path polarimeter for two-dimensional birefringence distribution measurement</title> (1999)

The paper covers an issue of method and device for measurement of 2D retardance and principal plane azimuth distributions. The system based on the use of a laser return-path polarimeter which consists of a rotating polarizing beam splitter and a quarter wave plate. Two or four sets from four images are used for birefringence analysis. This allows to decrease the errors caused by imperfection of a polarizing beam splitter and a quarter wave plate. The basic expressions that describe the operation of the systems are presented. The main sources of error are discussed. The measured results of the 2D birefringence distribution of a plastic and standard phase plate of retardation are shown.
Estimation of dose requirements for sustained<i>in vivo</i>activity of a therapeutic human anti‐CD20 antibody (2007)

We evaluated the dose requirements for sustained in vivo activity of ofatumumab, a human anti-CD20 antibody under development for the treatment of B cell-mediated diseases. In a mouse xenograft model, a single dose, resulting in an initial plasma antibody concentration of 5 microg/ml, which was expected to result in full target saturation, effectively inhibited human B-cell tumour development. Tumour growth resumed when plasma concentrations dropped below levels that are expected to result in half-maximal saturation. Notably, tumour load significantly impacted antibody pharmacokinetics. In monkeys, initial depletion of circulating and tissue residing B cells required relatively high-dose levels. Re-population of B-cell compartments, however, only became detectable when ofatumumab levels dropped below 10 microg/ml. We conclude that, once saturation of CD20 throughout the body has been reached by high initial dosing, plasma concentrations that maintain target saturation on circulating cells (5-10 microg/ml) are probably sufficient for sustained biological activity. These observations may provide a rationale for establishing dosing schedules for maintenance immunotherapy following initial depletion of CD20 positive (tumour) cells.
Resistance to CD95/Fas‐induced and ceramide‐mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome <i>c</i> release (2000)

Intracellular CD95/Fas-signaling pathways have not been investigated in melanoma yet. Two different CD95 receptor-induced apoptotic pathways are presently known in other cell types: (i) direct activation of caspase-8 and (ii) induction of ceramide-mediated mitochondrial activation, both leading to subsequent caspase-3 activation. In the present study, five of 11 melanoma cell populations were shown to release cytochrome c from mitochondria, which activates caspase-3 and finally results in DNA fragmentation upon treatment with the agonistic monoclonal antibody CH-11. In contrast, this apoptotic pathway was not activated in the remaining six melanoma cell populations. Interestingly, the susceptibility of melanoma cells to CD95L/FasL-triggered cell death was clearly correlated with N-acetylsphingosine-mediated apoptosis. Our results are in line with a defect upstream of mitochondrial cytochrome c release in resistant cells.
Automatic equalization using the discrete frequency domain (1973)

A new mean-square-error automatic equalizer for synchronous data transmission is developed. It utilizes Rosen's gradient-projection method to optimize parameters in the discrete frequency domain. The algorithm converges (in the mean) for any channel even in the presence of noise. It is shown that for the channels considered, convergence is faster (in a bounded sense) than for comparable time-domain equalizers.
Cloning of soybean leghemoglobin structural gene sequences synthesized in vitro (1979)

Double-stranded soybean leghemoglobin DNA was synthesized from leghemoglobin mRNA isolated from soybean nodules. The dsDNA was inserted into the Bam H1 site of plasmid pBR322 using the poly-dAT-joiner method. A cloned DNA fragment of one recombinant plasmid was isolated and characterized by restriction endonuclease digestion. The restriction cleavage map and the DNA sequence of a selected part of the inserted DNA are in complete accordance with the amino-acid sequence of soybean leghemoglobin.
How Many Drugs Are Catecholics (2007)

By examination of the 8659 drugs recorded in the Comprehensive Medicinal Chemistry (CMC) database, 78 catecholics (including five pyrogallolics) were identified, of which 17 are currently prescribed by FDA. Through analyzing the substituent patterns, ClogPs and O-H bond dissociation enthalpies (BDEs) of the catecholic drugs, some molecular features that may benefit circumventing the toxicity of catecholics were revealed: i) strong electron-donating substituents are excluded; ii) ClogP 3; iii) an energy penalty exists for quinone formation. Besides, the present analyses also suggest that the clinical usage and dosage of currently prescribed catecholic drugs are of importance in designing or screening catecholic antioxidants.
ChemInform Abstract: 2′‐ and/or 3′‐Deoxy‐β‐L‐pentofuranosyl Nucleoside Derivatives: Stereospecific Synthesis and Antiviral Activities. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Detection of composite edges (1994)

The paper presents a new parametric model-based approach to high-precision composite edge detection using orthogonal Zernike moment-based operators. It deals with two types of composite edges: (a) generalized step and (b) pulse/staircase edges. A 2-D generalized step edge is modeled in terms of five parameters: two gradients on two sides of the edge, the distance from the center of the candidate pixel, the orientation of the edge and the step size at the location of the edge. A 2-D pulse/staircase edge is modeled in terms of two steps located at two positions within the mask, and the edge orientation. A pulse edge is formed if the steps are of opposite polarities whereas a staircase edge results from two steps having the same polarity. Two complex and two real Zernike moment-based masks are designed to determine parameters of both the 2-D edge models. For a given edge model, estimated parameter values at a point are used to detect the presence or absence of that type of edge. Extensive noise analysis is performed to demonstrate the robustness of the proposed operators. Experimental results with intensity and range images are included to demonstrate the efficacy of the proposed edge detection technique as well as to compare its performance with the geometric moment-based step edge detection technique and Canny's (1986) edge detector.
Amicus Opinion (Republic of the Philippines v Maler Foundation) (2013)

Opinion as amicus curiae submitted to the Singapore Court of Appeal
An RNN Architecture with Dynamic Temporal Matching for Personalized Predictions of Parkinson's Disease (2017)

Parkinson's disease (PD) is a chronic disease that develops over years and varies dramatically in its clinical manifestations. A preferred strategy to resolve this heterogeneity and thus enable better prognosis and targeted therapies is to segment out more homogeneous patient sub-populations. However, it is challenging to evaluate the clinical similarities among patients because of the longitudinality and temporality of their records. To address this issue, we propose a deep model that directly learns patient similarity from longitudinal and multi-modal patient records with an Recurrent Neural Network (RNN) architecture, which learns the similarity between two longitudinal patient record sequences through dynamically matching temporal patterns in patient sequences. Evaluations on real world patient records demonstrate the promising utility and efficacy of the proposed architecture in personalized predictions.
QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY (2018)

Capillary nonperfusion area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion on wide-field OCTA may be useful for early detection and monitoring of disease in patients with diabetes and DR.
Vaccination of tumor cells transfected with the B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice (1996)

The present study demonstrates that the transfection of B7-1 or its variant MB7-2 genes into MHC class I+ tumor cells (B16-BL6 or K1735-M2 melanoma) resulted in the remarkable reduction of lung metastasis caused by i.v. injection into immunocompetent syngeneic mice. However, i.v. injection of the transfectants into T cell-deficient nude mice did not affect reduction of lung tumor colonies as compared with parental wild-type tumors, suggesting that such an inhibitory effect was closely associated with T cell-mediated responses. The reduced metastasis of B7+ tumor cells consequently led to the significant prolongation of survival. Expression of B7 on tumor cells did not influence the tumorigenicity in vivo and tumor cell invasion into basement membrane Matrigel in vitro. We also found that immunization of X-irradiated B7 transfectants was effective as a tumor vaccine for preventing lung metastasis caused by i.v. injection of B7- parental B16-BL6 cells but not against other syngeneic 3LL tumors. Thus, the B7-mediated anti-metastatic effect was tumor-specific. Vaccinations of irradiated B7+ tumor cells before and after surgical excision of the s.c. inoculated primary B7- tumors on day 21 achieved effectively the prevention of spontaneous lung metastasis. Our report that vaccination of irradiated B7+ tumor cells led to a therapeutic effect in an established tumor metastasis model clearly expands and confirms previous related observations.
The Anthelmintic Activity of the Cyclotides: Natural Variants with Enhanced Activity (2008)

The cyclotides are a family of backbone-cyclised cystine-knot-containing peptides from plants that possess anthelmintic activity against Haemonchus contortus and Trichostrongylus colubriformis, two important gastrointestinal nematode parasites of sheep. In the current study, we investigated the in vitro effects of newly discovered natural cyclotides on the viability of larval and adult life stages of these pests. The natural variants cycloviolacin O2, cycloviolacin O3, cycloviolacin O8, cycloviolacin O13, cycloviolacin O14, cycloviolacin O15, and cycloviolacin O16 extracted from Viola odorata showed up to 18-fold greater potency than the prototypic cyclotide kalata B1 in nematode larval development assays. Cycloviolacin O2 and cycloviolacin O14 were significantly more potent than kalata B1 in adult H. contortus motility assays. The lysine and glutamic acid residues of cycloviolacin O2, the most potent anthelmintic cyclotide, were chemically modified to investigate the role of these charged residues in modulating the biological activity. The single glutamic acid residue, which is conserved across all known cyclotides, was shown to be essential for activity, with a sixfold decrease in potency of cycloviolacin O2 following methylation. The three lysine residues present in cycloviolacin O2 were acetylated to effectively mask the positive charge, resulting in a 18-fold decrease in anthelmintic activity. The relative anthelmintic activities of the natural variants assayed against nematode larvae correlated with the number of charged residues present in their sequence.
Multi-frequency and multi-mode GHz surface acoustic wave sensor (2004)

We present a novel surface acoustic wave sensor, incorporating the advantages of multi-frequency and multi-mode operation in a single acoustic device structure. SAW sensors are commonly based on the change of the effective elastic constants or the mass loading of the device due to a different sensor environment. Usually, single acoustic modes at a fixed frequency are employed allowing for the detection of a certain chemical species, depending on the coating of the wave's propagation path. Analyzing multiple acoustic modes or multiple excitation frequencies that are each reacting differently on a particular load, allows for the multi-parameter analysis of gases and liquids. We present a sensor system that is based on floating electrode unidirectional transducers (FEUDTs) allowing for the excitation of a set of 48 equally spaced frequencies and at least two acoustic modes (depending on the material system) in a single transducer structure. FEUDTs allow for the efficient excitation of acoustic waves at GHz frequencies without the use of sophisticated nanofabrication techniques. Higher frequencies, on the other hand, are advantageous for the sensitivity of the device. We tested the basic operation of our sensor system by applying it to humidity sensing without a sensitive layer.
Terrestrial-satellite integration in dynamic 5G backhaul networks (2016)

This paper presents a dynamic backhaul network in order to face some of the main 5G challenges such as 100% coverage, improved capacity or reduction in energy consumption. The proposed solution, elaborated within the SANSA H2020 project, is based on the seamless integration of the satellite component in a terrestrial network capable of reconfiguring its topology according to the traffic demands. The paper highlights the benefits of this hybrid network and describes the technology enablers to bring it to the reality. Finally, the SANSA's network simulation framework based on ns3 is presented, jointly with a preliminary analysis of the routing and load balancing needs for a hybrid and dynamic network.
A path to understanding the effects of algorithm awareness (2014)

The rise in prevalence of algorithmically curated feeds in online news and social media sites raises a new question for designers, critics, and scholars of media: how aware are users of the role of algorithms and filters in their news sources? This paper situates this problem within the history of design for interaction, with an emphasis on the contemporary challenges of studying, and designing for, the algorithmic "curation" of feeds. Such a problem presents particular challenges when, as is common, neither the user nor the researcher has access to the actual proprietary algorithms at work.
Modeling of Ballistic Carbon Nanotube Field Effect Transistors for Efficient Circuit Simulation (2003)

Carbon Nanotube Field-Effect Transistors (CNFETs) are being extensively studied as possible successors to CMOS. Novel device structures have been fabricated and device simulators have been developed to estimate their performance in a sub 10 nm transistor era. This paper presents a novel method of circuit-compatible modeling of CNFETs in their ultimate performance limit. The model so developed has been used to simulate arithmetic and logic blocks using HSPICE.
The Origins of Pandemic Influenza — Lessons from the 1918 Virus (2005)

The 1918 virus spread rapidly around the world and was associated with mortality measured in the thousands per 100,000 population. Dr. Robert Belshe describes what the 1918 virus teaches us about avian H5N1 influenza.
Elements of the maize A1 promoter required for transactivation by the anthocyanin B/C1 or phlobaphene P regulatory genes. (1994)

The extensive genetic and molecular characterization of the flavonoid pathway's structural and regulatory genes has provided some of the most detailed knowledge of gene interactions in plants. In maize flavonoid biosynthesis, the A1 gene is independently regulated in the anthocyanin and phlobaphene pathways. Anthocyanin production requires the expression of the C1 or PI and R or B regulatory genes, whereas phlobaphene production requires only the P regulatory gene. By deletion analysis of the A1 promoter, we show that the sequences between -123 and -88 are critical for activation by anthocyanin and phlobaphene regulatory genes. Linker-scanner mutations indicated that the -123 to -100 region is more important for transactivation by the P protein. The -98 to -88 region is more important for B/C1 transactivation and shows a strong homology with the region of the Bz1 anthocyanin structural gene promoter shown to be activated by B/C1 and not by P. We identified a 14-bp consensus sequence that is also present in the promoters of three other genes in the anthocyanin pathway, and we propose a model for how the flavonoid regulatory proteins interact with the promoters of the structural genes.
The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86 (1993)

The response to tetanus toxoid (TT) was studied in immune donors that carry two alleles of DR5 that differ only at DR beta residue 86: DRB1*1101 (G86, abbreviated 1101) and DRB1*1104 (V86, abbreviated 1104). A large number of TT-specific T cell clones was isolated and the epitopes recognized in association with 1101 and 1104 were mapped. We found that two epitopes (p2 and p32) can be recognized in association with both 1101 and 1104 while three epitopes (p23, p27 and p30) are recognized in association with 1101, but never in association with 1104. The sets of naturally processed self peptides displayed by 1101 and 1104 were characterized using alloreactive T cell clones. We found that all 1104 alloreactive clones recognize both 1104 and 1101, while approximately 30% of the alloreactive 1101 clones fail to recognize 1104. Thus it is apparent that both naturally processed TT and self peptides displayed on 1104 molecules represent a fraction of those displayed on 1101 molecules. The mechanism responsible for this differential presentation was investigated by comparing the capacity of 1101 and 1104 antigen-presenting cells to present TT or synthetic peptides to specific T cells and by measuring the binding of these peptides to DR molecules. Three sets of results suggest that V86 acts as a constraint to the binding of naturally processed peptides: (i) all 1104-restricted or alloreactive T cell clones recognize TT- or allo-epitopes presented by 1101 as well, thus ruling out a major effect of V86 as a residue determining T cell restriction specificity; (ii) presentation of naturally processed peptides correlates in general with the capacity of long synthetic peptides to bind to 1101 or 1104 and (iii) while the naturally processed p30 epitope discriminates between 1101 and 1104, a short synthetic peptide binds equally well to and is comparably recognized in association with both 1101 and 1104. Taken together these results suggest that the natural polymorphism at residue 86 might be a molecular switch that finely tunes the complexity of the peptide collection presented on DR molecules.
Mathematical model and experimental investigation of polycarbonate pellet drying (1990)

Abstract An easy to use, spreadsheet based, mathematical model for drying of strand cut polymer pellets has been developed and experimentally verified. This particle‐scale model is based on internal mass‐transfer controlled diffusion in the pellet. Examples of its usage in correlation and prediction of the effects of the drying‐gas temperature, humidity, and pellet dimensions are presented. Application of the particle‐scale model to the design of a countercurrent hopper drier is discussed. Even though examples are limited to water removal from poly(bisphenol‐A)carbonate pellets, the model is general and may be used for the removal of other non‐solvating low‐concentration molecules from polymers with isotropic morphology.
Joint Enhancement and Denoising Method via Sequential Decomposition (2018)

Many low-light enhancement methods ignore intensive noise in original images. As a result, they often simultaneously enhance the noise as well. Furthermore, extra denoising procedures adopted by most methods ruin the details. In this paper, we introduce a joint low-light enhancement and denoising strategy, aimed at obtaining well-enhanced low-light images while getting rid of the inherent noise issue simultaneously. The proposed method performs Retinex model based decomposition in a successive sequence, which sequentially estimates a piece-wise smoothed illumination and a noise-suppressed reflectance. After getting the illumination and reflectance map, we adjust the illumination layer and generate our enhancement result. In this noise-suppressed sequential decomposition process we enforce the spatial smoothness on each component and skillfully make use of weight matrices to suppress the noise and improve the contrast. Results of extensive experiments demonstrate the effectiveness and practicability of our method. It performs well for a wide variety of images, and achieves better or comparable quality compared with the state-of-the-art methods.