gebhart/patrepeval huggingface dataset:
Die‐Off Ratio Correlates with Increased<scp>TNF</scp>‐α:<scp>IL</scp>‐10 Ratio and Decreased<scp>IVF</scp>Success Rates Correctable with<scp>H</scp>umira (2012)

In subfertile women undergoing IVF, the oocyte DOR may help predict IVF success rates. This factor may offer an additional tool to help improve implantation rate, clinical pregnancy rate, live birth rate, and live birth rate per embryo transferred for an upcoming IVF cycle. Although many mechanisms may contribute to the oocyte DOR's negative effect on IVF success rates, its correlation with elevated preconception TNF-α:IL-10 ratio and correction with Humira suggests a strong immunologic component that may be treatable.
Very high radix division with selection by rounding and prescaling (2002)

A division algorithm in which the quotient-digit selection is performed by rounding the shifted residual in carry-save form is presented. To allow the use of this simple function, the divisor (and dividend) is prescaled to a range close to one. The implementation presented results in a fast iteration because of the use of carry-save forms and suitable recodings. The execution time is calculated, and several convenient values of the radix are selected. Comparison with other high-radix dividers is performed using the same assumptions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lamin A/C Expression Is a Marker of Mouse and Human Embryonic Stem Cell Differentiation (2005)

Nuclear lamins comprise the nuclear lamina, a scaffold-like structure that lines the inner nuclear membrane. B-type lamins are present in almost all cell types, but A-type lamins are expressed predominantly in differentiated cells, suggesting a role in maintenance of the differentiated state. Previous studies have shown that lamin A/C is not expressed during mouse development before day 9, nor in undifferentiated mouse embryonic carcinoma cells. To further investigate the role of lamins in cell phenotype maintenance and differentiation, we examined lamin expression in undifferentiated mouse and human embryonic stem (ES) cells. Wide-field and confocal immunofluorescence microscopy and semiquantitative reverse transcription-polymerase chain reaction analysis revealed that undifferentiated mouse and human ES cells express lamins B1 and B2 but not lamin A/C. Mouse ES cells display high levels of lamins B1 and B2 localized both at the nuclear periphery and throughout the nucleoplasm, but in human ES cells, B1 and B2 expression is dimmer and localized primarily at the nuclear periphery. Lamin A/C expression is activated during human ES cell differentiation before downregulation of the pluripotency marker Oct-3/4 but not before the downregulation of the pluripotency markers Tra-1-60, Tra-1-81, and SSEA-4. Our results identify the absence of A-type lamin expression as a novel marker for undifferentiated ES cells and further support a role for nuclear lamins in cell maintenance and differentiation.
A General Framework for Service Availability for Bandwidth-Efficient Connection-Oriented Networks (2010)

Availability in connection-oriented service in networks has traditionally been all-or-nothing, i.e., when a failure occurs, a connection either is unprotected or fully protected. The differences in availability and cost between these two extremes can be quite high. A general framework for service availability will be presented that fills the gap. It is shown how network resources and cost are related to service parameters of the framework for networks that are bandwidth-efficient. In addition, a simple revenue model is presented and characterized, revealing when nontraditional service agreements may be attractive.
Evidence of cross reaction potential of recombinant leptospira LipL41 protein (2014)

The present study was undertaken to compare the cross reactive potentiality of expressed recombinant protein (LipL41) with lipopolysaccharide (LPS) antigen of leptospira against different serovars of leptospira. Antigens from both recombinant LipL41 and the isolated LPS from Leptospira icterohaemorrhagiae were coated in latex beads and used to test the human sera samples of different serovars of leptospira using field based latex agglutination test. Recombinant antigen showed strong cross reaction with different serovars of leptospira, whereas LPS antigen showed very mild cross reaction with few serovars. This clearly indicates that outer membrane protein cross reacted with heterologous serovars and can be used as effective diagnostic agent as well as candidate antigen for development of vaccine for leptospira.
Design Analysis of Car Radiator in an Engine Cooling System (2018)

This paper refers to the design analysis of automotive radiator in engine cooling system. This analysis aims to design the more compact radiator that transfers the equivalent amount of heat of the existing radiator. Both LMTD (Log Mean Temperature Difference) and e-NTU (effectiveness-Number of Transfer Units) methods are commonly used for design and thermal analysis of radiator. In this paper, the design analysis of automotive radiator is described by using e-NTU method. The results obtained from the analysis are presented. Finally, calculated results with actual values have been compared. This calculation can be done using MATLAB software.
Structure−Property Relations of Regiosymmetrical 3,4-Dioxy-Functionalized Polythiophenes (2005)

We present the synthesis and characterization of novel homo- and copolymers containing mono- and dialkylated 3,4-propylenedioxythiophenes with the purpose of creating new π-conjugated polymers to be exploited in the field of polymer electronics and photonics. We show that the large seven-membered dioxepine ring attached to the thiophene moiety causes unfavorable steric interactions, especially in the homopolymers; it thus prevents the polymers from adapting a coplanar structure with a short π-stacking distance in the solid state. We furthermore show that incorporation of less space filling units in the form of unsubstituted thiophene units into the polymer chain reduces these unfavorable interactions and therefore allows for a more coplanar polymer backbone orientation and a shorter π-stacking distance in the solid state. These findings are based on absorption spectroscopy, electrochemical measurements, X-ray powder diffraction, and conductivity measurements.
The administration of folic acid improves erectile function and reduces intracavernosal oxidative stress in the diabetic rabbit (2008)

The administration of FA may constitute a strategy for reducing ED in patients with DM.
Distinct Modes of Macrophage Recognition for Apoptotic and Necrotic Cells Are Not Specified Exclusively by Phosphatidylserine Exposure (2001)

The distinction between physiological (apoptotic) and pathological (necrotic) cell deaths reflects mechanistic differences in cellular disintegration and is of functional significance with respect to the outcomes that are triggered by the cell corpses. Mechanistically, apoptotic cells die via an active and ordered pathway; necrotic deaths, conversely, are chaotic and passive. Macrophages and other phagocytic cells recognize and engulf these dead cells. This clearance is believed to reveal an innate immunity, associated with inflammation in cases of pathological but not physiological cell deaths. Using objective and quantitative measures to assess these processes, we find that macrophages bind and engulf native apoptotic and necrotic cells to similar extents and with similar kinetics. However, recognition of these two classes of dying cells occurs via distinct and noncompeting mechanisms. Phosphatidylserine, which is externalized on both apoptotic and necrotic cells, is not a specific ligand for the recognition of either one. The distinct modes of recognition for these different corpses are linked to opposing responses from engulfing macrophages. Necrotic cells, when recognized, enhance proinflammatory responses of activated macrophages, although they are not sufficient to trigger macrophage activation. In marked contrast, apoptotic cells profoundly inhibit phlogistic macrophage responses; this represents a cell-associated, dominant-acting anti-inflammatory signaling activity acquired posttranslationally during the process of physiological cell death.
Optimization of the composition of solid dispersion of quercetin (2021)

Abstract Increasing the solubility of drugs is one of the most important problems in pharmacy, because most manufactured pharmaceutical substances are sparingly soluble. Typically, such compounds represent Classes II and IV in the biopharmaceutical classification system, which is based on the classification of pharmaceutical substances by solubility and permeability. For poorly soluble substances, the limiting step of the absorption process is usually the degree and dissolution rate, so in the pharmaceutical development, much attention is paid to their improvement. To solve this problem, the technology of solid dispersions creation is used. The aim of the work was to optimize the composition of quercetin solid dispersion, whose therapeutic use is limited due to its degree of solubility in an aqueous medium. Objects of the study were samples of solid dispersions of quercetin with different carriers: polyethyleneoxide-6000, β-cyclodextrin and polyvinylpyrrolidone obtained in a ratio of 1:1 and 1:2 by liquid phase method, with and without the addition of a solvent. As a solvent, ethanol was used. To determine the optimal composition of solid dispersions, a mathematical planning method using the MathCad package and Excel software was used. In the work, a dispersion analysis was performed upon the results of the experimental studies. The ranked series of advantages of the carrier and solvent influence on solubility of solid dispersions samples are shown. To determine the amount of carrier in the solid dispersion, the theory of multi-vector optimization was applied. According to the results of the conducted studies, the optimal value of quercetin and PEO-6000 ratio is 1:2. The obtained results can be used in the development of the composition and technology of solid dispersions of active pharmaceutical ingredients insoluble in the aqueous medium.
Contribution à la conception d'architecture de calcul auto-adaptative intégrant des nanocomposants neuromorphiques et applications potentielles (2012)

In this thesis, we study the potential applications of emerging memory nano-devices in computing architecture. More precisely, we show that neuro-inspired architectural paradigms could provide the efficiency and adaptability required in some complex image/audio processing and classification applications. This, at a much lower cost in terms of power consumption and silicon area than current Von Neumann-derived architectures, thanks to a synaptic-like usage of these memory nano-devices. This work is focusing on memristive nano-devices, recently (re-)introduced by the discovery of the memristor in 2008 and their use as synapses in spiking neural network. In fact, this includes most of the emerging memory technologies: Phase-Change Memory (PCM), Conductive-Bridging RAM (CBRAM), Resistive RAM (RRAM)... These devices are particularly suitable for the implementation of natural unsupervised learning algorithms like Spike-Timing-Dependent Plasticity (STDP), requiring very little control circuitry.The integration of memristive devices in crossbar array could provide the huge density required by this type of architecture (several thousand synapses per neuron), which is impossible to match with a CMOS-only implementation. This can be seen as one of the main factors that hindered the rise of CMOS-based neural network computing architectures in the nineties, among the relative complexity and inefficiency of the back-propagation learning algorithm, despite all the promising aspects of such neuro-inspired architectures, like adaptability and fault-tolerance. In this work, we propose synaptic models for memristive devices and simulation methodologies for architectural design exploiting them. Novel neuro-inspired architectures are introduced and simulated for natural data processing. They exploit the synaptic characteristics of memristives nano-devices, along with the latest progresses in neurosciences. Finally, we propose hardware implementations for several device types. We assess their scalability and power efficiency potential, and their robustness to variability and faults, which are unavoidable at the nanometric scale of these devices. This last point is of prime importance, as it constitutes today the main difficulty for the integration of these emerging technologies in digital memories.
Experience in implementing a document delivery service (2000)

In this paper we propose an integration between electronic mail and web services for people such as library operators who need to send large files to Internet users. The proposed solution permits libraries to continue using the e-mail service to send large documents, but at the same time overcomes problems that users can encounter downloading large size files with e-mail agents. The library operator sends the document as an attachment to the destination address, on fly the e-mail server extracts and saves the attachments in a web-server disk file and substitutes them with a new messsage part that includes the URL pointing to the saved document. The reciever can download these large objects using a user-friendly browser.
Nationwide Population-based Epidemiological Study of Intracranial and Intraspinal Abscesses in Taiwan (2014)

Little is known about the epidemiology of intracranial and intraspinal abscesses in Taiwan. Therefore, we conducted the first population-based epidemiological study of these diseases in Taiwan. Cases of intracranial and intraspinal abscesses were retrieved from the National Health Insurance Research Database of Taiwan using any of the 5 main discharge diagnostic codes beginning with 324 in the International Classification of Diseases, Ninth Revision, Clinical Modification during 2000 ~ 2007. There were 6,658 patients with intracranial or intraspinal abscesses who utilized 9,812 inpatient services during the study period. The average incidence rate was 3.68 per 100,000 person-years. There was a higher incidence rate among men than women, with a male/female incidence ratio of 2.2. The age-specific incidence rate peaked at age 65 ~ 69 for men and 70 ~ 74 for women. Septicemia, osteomyelitis and type 2 diabetes mellitus were the most common co-existing diagnoses. The average cost of treating one patient with the disease was 334,131 New Taiwan Dollars. The mean acute ward stay was 28.5 days. This was the first nationwide, population-based epidemiologic study of intracranial and intraspinal abscesses. Our data revealed the high medical costs and long hospital course involved in treating the disease.
Lincomycin. VI. 4′-Alkyl Analogs of Lincomycin. Relationship between Structure and Antibacterial Activity (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLincomycin. VI. 4′-Alkyl Analogs of Lincomycin. Relationship between Structure and Antibacterial ActivityBarney J. Magerlein, Robert D. Birkenmeyer, and Fred. KaganCite this: J. Med. Chem. 1967, 10, 3, 355–359Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/jm00315a015https://doi.org/10.1021/jm00315a015research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunotherapy of systemic sclerosis (2010)

Scleroderma is a multisystem autoimmune disease characterized by an abnormal immune activation associated with the development of underlying vascular and fibrotic disease manifestations. This article highlights the current use of drugs targeting the immune system in scleroderma. Nonselective immunosuppression, and in particular cyclophosphamide, remains the main treatment for progressing skin involvement and active interstitial lung disease. Mycophenolate mofetil is a promising alternative to cyclophosphamide. The use of cyclosporine has been limited by modest efficacy and serious renal toxicity. Newer T-cell (sirolimus and alefacept) and B-cell (rituximab)-targeted therapies have provided some encouraging results in small pilot studies. Hematopoietic stem cell transplantation can be effective for severe fibrotic skin disease, but toxicity remains a concern. Clinical efficacy and safety of antifibrotic treatments (e.g., imatinib) await confirmation. Newer biological agents targeting key molecular or cellular effectors in scleroderma pathogenesis are now available for clinical testing.
Pipelined sampled-delay focusing CMOS implementation for ultrasonic digital beamforming (2004)

The real-time ultrasonic imaging system can be achieved using a digital beamforming (DBF) method. The critical part of the DBF is the real-time sampled-delay focusing (SDF) which requires a large number of memories (FIFO) to store the scanned information. The sampled-delay focusing technique is used to eliminate the use of the analog delay lines. This paper concerns the design and implementation of pipelined sampled-delay architecture for ultrasonic digital beamforming. The design uses a minimum size look-up memory to store the initial scan information as opposed to previous approaches. The circuit is implemented in CMOS 0.18 /spl mu/m technology and the resulting active layout area is 0.14 mm/sup 2/, while its total power consumption is below 40 mW.
Phase Separation Behavior of Supercharged Proteins and Polyelectrolytes (2017)

Membraneless organelles, like membrane-bound organelles, are essential to cell homeostasis and provide discrete cellular subcompartments. Unlike classical organelles, membraneless organelles possess no physical barrier but rather arise by phase separation of the organelle components from the surrounding cytoplasm or nucleoplasm. Complex coacervation, the liquid-liquid phase separation of oppositely charged polyelectrolytes, is one of several phenomena that are hypothesized to drive the formation and regulation of some membraneless organelles. Studies of the molecular properties of globular proteins that drive complex coacervation are limited as many proteins do not form complexes with oppositely charged macromolecules at neutral pH and moderate ionic strengths. Protein supercharging overcomes this problem and drives complexation with oppositely charged macromolecules. In this work, several distinct cationic supercharged green fluorescent protein (GFP) variants were designed to examine the phase behavior with oppositely charged polyanionic macromolecules. Cationic GFP variants phase separated with oppositely charged macromolecules at various mixing ratios, salt concentrations, and pH values. Efficient protein incorporation in the macromolecule rich phase occurred over a range of protein and polymer mass fractions, but the protein encapsulation efficiency was highest at the midpoint of the phase separation regime. More positively charged proteins phase separated over broader pH and salt ranges than those of proteins with a lower charge density. Interestingly, each GFP variant phase separated at higher salt concentrations with anionic synthetic macromolecules compared to anionic biological macromolecules. Optical microscopy revealed that most variants, depending on solution conditions, formed liquid-liquid phase separations, except for GFP/DNA pairs that formed solid aggregates under all tested conditions.
Chemical and biological systems for regenerating activated carbon contaminated with high explosives (1994)

Activated carbon has been used as a substrate for efficiently removing high explosives (HEs) from aqueous and gaseous waste streams. Carbon that is saturated with HEs, however, constitutes a solid waste and is currently being stored because appropriate technologies for its treatment are not available. Because conventional treatment strategies (i.e., incineration, open burning) are not safe or will not be in compliance with future regulations, new and cost-effective methods are required for the elimination of this solid waste. Furthermore, because the purchase of activated carbon and its disposal after loading with HEs will be expensive, an ideal treatment method would result in the regeneration of the carbon thereby permitting its reuse. Coupling chemical and biological treatment systems, such as those described below, will effectively meet these technical requirements. The successful completion of this project will result in the creation of engineered commercial systems that will present safe and efficient methods for reducing the quantities of HE-laden activated carbon wastes that are currently in storage or are generated as a result of demilitarization activities. Biological treatment of hazardous wastes is desirable because the biodegradation process ultimately leads to the mineralization (e.g., conversion to carbon dioxide, nitrogen gas, and water) of parent compounds and has favorable public acceptance. These methods will also be cost- effective because they will not require large expenditures of energy and will permit the reuse of the activated carbon. Accordingly, this technology will have broad applications in the private sector and will be a prime candidate for technology transfer.
The Yucatan minature pig as a laboratory animal. (1978)

A boundary-element method is applied to solve the equations describing the deformation of a two-dimensional liquid region under the influence of gradients of the curvature of its outer boundary. This research is motivated by a desire to obtain a better understanding of viscous sintering processes in which a granular compact is heated to a temperature at which the viscosity of the constituent material becomes low enough for surface tension to cause adjacent particles to deform and coalesce. The boundary-element method is capable of showing how a moderately curved initial shape transforms itself into a circle. Initial shapes showing more extreme curvature gradients, which are relevant in the initial stages of a sintering process, cannot be dealt with by the boundary-element method in its present form. The numerical solution of the continuous model shows a tendency to create oscillations in the outer boundary of the liquid region. On the other hand, an analytical small-amplitude analysis shows that rapid oscillations vanish exponentially fast.