gebhart/patrepeval huggingface dataset:
Isolation of a Telomeric DNA Sequence from Drosophila melanogaster (1978)

There is substantial genetic and cytological evidence that the ends of a eukaryotic chromosome, the telomeres, are specialized structures which can mediate associations of chromosomes. On one hand, the telomeres appear to prevent the ends of chromosomes from fusing with one another (McClintock 1938, 1939, 1940, 1942). On the other hand, they promote transient, end-to-end associations of nonhomologous chromosomes during interphase and meiotic prophase in plant, insect, and mammalian nuclei (see White 1948; DuPraw 1970). This paper reports the finding of a DNA sequence, contained in the cloned segment Dm356, which is common to the termini of the five major chromosome arms of Drosophila melanogaster. Such a sequence may be a component of a common telomere structure and could explain such properties of telomeres as their capacity to associate.
1,3-Dipolar cycloaddition of alkynes to azides. Construction of operationally functional metal responsive fluorophores (2008)

The copper catalyzed 1,3-dipolar cycloaddition of 4-butoxyphenylazide with 2-, 3- or 4-ethynylpyridine furnishes 1,4-diaryltriazoles, which display turn-on fluorescence upon addition of metal cations.
Recent advances in solid sorbents for CO<sub>2</sub>capture and new development trends (2014)

Carbon dioxide (CO<sub>2</sub>) capture using solid sorbents has been recognized as a very promising technology that has attracted intense attention from both academic and industrial fields in the last decade.
Phase Behaviour of Uncured and UV-cured (2-ethylhexylacrylate-1,6-hexanedioldiacrylate)/E7 Mixtures (2004)

The equilibrium phase diagram of UV-cured (2-ethylhexylacrylate-1,6-hexanedioldiacrylate) and the multicomponent nematic fluid E7 is established by polarized optical microscopy and differential scanning calorimetry. The enthalpy changes at the nematic-isotropic transition for both uncured and UV-cured samples are used to determine the liquid crystal (LC) solubility limit in the acrylate rich phase and to estimate the fractional amount of phase separated LC.
Correction: Phosphorylation of bio-based compounds: the state of the art (2016)

Correction for ‘Phosphorylation of bio-based compounds: the state of the art’ by Nicolas Illy, <italic>et al.</italic>, <italic>Polym. Chem.</italic>, 2015, <bold>6</bold>, 6257–6291.
Design Data for Hot-via Interconnects in Chip Scale Packaged MMICs up to 110 GHz (2005)

Theoretical and experimental design data for the modeling of bump- to hot-via interconnect transitions, for use in chip-scale package MMICs, is presented. The theoretical data is based on cascaded analytical transmission line models, derived from rigorous electromagnetic analysis. Excellent agreement has been observed between theory and experiment up to 110 GHz. This modeling approach is validated with the characterization of a broadband millimeter-wave PHEMT amplifier MMIC using the hot-via and bump interconnects, for mounting on a carrier substrate; the measurements are as well, in very good concordance with the predicted performance, including the effects of BCB coating, backside metallization and bump- to hot-via transitions.
Adaptive storage battery management based on the Energy on Demand protocol (2012)

We proposed the concept of i-Energy [1] as a novel smart demand-side energy management scheme to realize efficient and versatile control of e-power flows among decentralized energy generation/storage devices and appliances in homes, offices, and neighboring communities. To embody the concept, we developed a novel energy management method named Energy on Demand (EoD) for a single power source [3]. This paper proposes an adaptive storage battery management method based on EoD. The novelty of the method rests in the demand-based battery capacity design and dynamic charge/discharge control. The effectiveness of the proposed method has been proved with experiments using real life data in the smart apartment room [5].
Prosthetic visual perception: retinal electrical stimulation in blind human patients (2015)

Can functional vision be restored in blind human subjects using a microelectronic retinal prosthesis? The initial indications suggest that, yes, it is possible. However, the visual experience of these subjects is nothing like a digital scoreboard-like movie, with each electrode acting as an independent pixel. The work described here suggests that there are interactions between pulses and across electrodes, at the electrical, retinal, or even cortical level that influence the quality of the percept. In particular, this work addresses the question, "how does the percept change as a function of pulse timing on single and multiple electrodes"? The motivation for the work described here is that these interactions must be understood and predictable if we are to develop a functional tool for blind human patients.
A Distributed QoS MAC Protocol for Wireless Mesh (2008)

Abundant hidden node collisions and correlated channel access due to multi-hop flows degrade QoS in wireless mesh networks. QoS in nearby WLANs operating on a single channel is also affected. We propose using wider contention windows for backoff to lower the risk of repeated hidden-node collisions, a spatial extension of the TXOP concept called 'express forwarding' to clear multi-hop flows sooner, and a new mechanism called 'express re-transmission' to reduce collisions on retransmission. Simulation results show the potential benefit of the proposed enhancements and impact on fairness.
Infection of CD4+ Memory T Cells by HIV-1 Requires Expression of Phosphodiesterase 4 (2000)

Using PCR to monitor HIV-1 RNA genome reverse transcription and nuclear import of preintegration complexes, we found that memory, but not naive, CD4+ T cells could support transport of HIV-1 DNA to nuclei upon TCR/CD3 and IL-2 stimulation. Moreover, memory CD4+ T cells, unlike naive CD4+ T cells, express high levels of phosphodiesterase 4 (PDE4) constitutively. Selective blocking of PDE4 activity inhibited IL-2R expression and thereby led to abolishing HIV-1 DNA nuclear import in memory T cells; however, full-length viral DNA synthesis was not affected. Thus, blocking PDE4 prevents initiation of HIV-1 DNA circle formation in T cells. The fact that PDE4 is expressed constitutively at higher levels in memory vs naive CD4+ T cells may help HIV-1 readily infect memory T cells.
Women's Experiences With Genital Touching, Sexual Pleasure, and Orgasm: Results From a U.S. Probability Sample of Women Ages 18 to 94 (2017)

The study purpose was to assess, in a U.S. probability sample of women, experiences related to orgasm, sexual pleasure, and genital touching. In June 2015, 1,055 women ages 18 to 94 from the nationally representative GfK KnowledgePanel® completed a confidential, Internet-based survey. While 18.4% of women reported that intercourse alone was sufficient for orgasm, 36.6% reported clitoral stimulation was necessary for orgasm during intercourse, and an additional 36% indicated that, while clitoral stimulation was not needed, their orgasms feel better if their clitoris is stimulated during intercourse. Women reported diverse preferences for genital touch location, pressure, shape, and pattern. Clinical, therapeutic, and educational implications are discussed.
Identification of G protein-coupled receptors in Schistosoma haematobium and S. mansoni by comparative genomics (2014)

Most GPCRs shared a high degree of similarity and conservation, except for members of a particular clade (designated SmGPR), which appear to have diverged between S. haematobium and S. mansoni and might explain, to some extent, some of the underlying biological differences between these two schistosomes. The present set of annotated GPCRs provides a basis for future functional genomic studies of cellular GPCR-mediated signal transduction and a resource for future drug discovery efforts in schistosomes.
Foxtrot: phase space data representation for correlation-aware aggregation (2007)

Most existing work in aggregation and querying for sensor network data has focused on the use of standard statistical operations (average, median, etc) to reduce the quantity of transmitted data within a network These operations have been carried out without considering the nature of the actual data in the network. In this paper, we show how aggregation without correlation awareness will result in variable (often high) levels of error in the end results, and reformulate the nature of the aggregation problem in terms of information loss v.s. packet rate reduction. We instead propose Foxtrot - using phase space data representation combined with novel aggregation methods to limit errors to application-specific ranges. Foxtrot reduces data rates without significant information loss. We demonstrate that Foxtrot is able to achieve these goals, both using simulation methods and a TinyOS implementation.
Effects of Fiber Architecture on Matrix Cracking for Melt‐Infiltrated SiC/SiC Composites (2009)

The matrix cracking behavior of slurry cast melt‐infiltrated SiC matrix composites consisting of Sylramic‐iBN fibers with a wide variety of fiber architectures were compared. The fiber architectures included 2D woven, braided, 3D orthogonal, and angle interlock architectures. Acoustic emission was used to monitor in‐plane matrix cracking during unload–reload tensile tests. Two key parameters were found to control matrix‐cracking behavior: the fiber volume fraction in the loading direction and the area of the weakest portion of the structure, that is, the largest tow in the architecture perpendicular to the loading direction. Empirical models that support these results are presented and discussed.
The Congestion Manager (2001)

This document describes the Congestion Manager (CM), an end-system module that:(i) Enables an ensemble of multiple concurrent streams from a sender destined to the same receiver and sharing the same congestion properties to perform proper congestion avoidance and control, and (ii) Allows applications to easily adapt to network congestion.1.
Interventions for replacing missing teeth: bone augmentation techniques for dental implant treatment (2008)

Major bone grafting procedures of resorbed mandibles may not be justified. Bone substitutes (Bio-Oss or Cerasorb) may replace autogenous bone for sinus lift procedures of atrophic maxillary sinuses. Various techniques can augment bone horizontally and vertically, but it is unclear which is the most efficient. It is unclear whether augmentation procedures at immediate single implants placed in fresh extraction sockets are needed, and which is the most effective augmentation procedure, however, sites treated with barrier plus Bio-Oss showed a higher position of the gingival margin when compared to sites treated with barriers alone. Non-resorbable barriers at fenestrated implants regenerated more bone than no barriers, however it remains unclear whether such bone is of benefit to the patient. It is unclear which is the most effective technique for augmenting bone around fenestrated implants. Bone morphogenetic proteins may enhance bone formation around implants grafted with Bio-Oss. Titanium may be preferable to resorbable screws to fixate onlay bone grafts. The use of particulate autogenous bone from intraoral locations, also taken with dedicated aspirators, might be associated with an increased risk of infective complications. These findings are based on few trials including few patients, sometimes having short follow up, and often being judged to be at high risk of bias.
Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation (2004)

Matrix metalloproteinases (MMPs) are critical mediators of tissue remodeling. Inappropriate regulation of MMPs causes many pathological events, including microbial invasion and inflammatory tissue damage. Some of the bacterial exoproteinases can effectively activate pro-MMPs (inactive zymogens) via limited proteolysis around their autoinhibitory domains. In addition, overproduction of nitric oxide (NO) may contribute to respiratory inflammation via the formation of reactive nitrogen species (RNS). Several studies have identified regulatory properties of NO/RNS on biomolecules due to functional modification of their cysteine residues. In fact, NO/RNS can mediate activation and expression of MMPs, because RNS can interact with a cysteine switch in the autoinhibitory domain, thus converting proMMPs into their active forms without proteolysis. Many studies have indicated that NO/RNS can participate in expression of various genes that affect immune-inflammatory responses, including MMPs. Although NO in some cases upregulates MMPs, S -nitrosothiols downregulate MMP-9 expression by suppressing the NF-kappaB pathway. While microbial proteinases cause excessive activation of MMPs and contribute to microbial pathogenesis, NO/RNS may modulate expression and activation of MMPs as well as various inflammatory mediators, depending on the redox status at sites of inflammation. Therefore, appropriate regulation of MMPs may be of potential therapeutic value for various infections and inflammatory lung diseases.
Noninvasive Quantification of Regional Myocardial Metabolic Rate of Oxygen by <sup>15</sup> O <sub>2</sub> Inhalation and Positron Emission Tomography (1996)

Accurate quantification of OEF and MMRO2 is feasible with 15O2 inhalation and PET imaging using both the steady-state and autoradiographic analytical approaches. These studies suggest the applicability of this method for quantitative assessments of regional cardiac oxidative metabolism in clinical studies.
Impedance and Temperature Monitoring Improve the Safety of Closed‐Loop Irrigated‐Tip Radiofrequency Ablation (2007)

Temperature control improved the safety profile during irrigated-tip ablation in comparison with fixed-power ablations, but resulted in significantly smaller lesions. Impedance-controlled ablation lesions (target 10 ohm drop) created lesions of comparable size to fixed-power ablations with a significantly better safety profile.
Efficient Simulation of Parallel Computer Systems. (1991)

In summary, conventional CAPD fluids may interfere with most pathways of the intraperitoneal network of cytokines (Figure 4), potentially resulting in an impairment of important host defense functions. Thus alternative approaches are needed in order to improve dialysis fluid biocompatibility. Initial results indicate that pH neutralization and a restriction to moderate osmolality might constitute important determinants of modern dialysis fluid technology; however, clinical studies will have to prove that these fluids indeed improve the clinical outcome of the patients on long-term CAPD therapy.
Identification of Tumor-Infiltrating Macrophages as the Killers of Tumor Cells After Immunization in a Rat Model System (2001)

Immunization can prevent tumor growth, but the effector cells directly responsible for tumor cell killing in immunized hosts remain undetermined. The present study compares tumor grafts that progress in naive syngeneic rats with the same grafts that completely regress in hosts preimmunized with an immunogenic cell variant. The progressive tumors contain only a few macrophages that remain at the periphery of the tumor without direct contact with the cancer cells. These macrophages do not kill tumor cells in vitro. In contrast, tumors grafted in immunized hosts and examined at the beginning of tumor regression show a dramatic infiltration with mature macrophages, many of them in direct contact with the cancer cells. These macrophages are strongly cytotoxic for the tumor cells in vitro. In contrast to macrophages, tumor-associated lymphocytes are not directly cytotoxic to the tumor cells, even when obtained from tumor-immune rats. However, CD4(+) and CD8(+) T cells prepared from the regressing tumors induce tumoricidal activity in splenic macrophages from normal or tumor-bearing rats and in macrophages that infiltrate progressive tumors. These results strongly suggest that the main tumoricidal effector cells in preimmunized rats are macrophages that have been activated by adjacent tumor-immune lymphocytes.
CFA Bayer image sequence denoising and demosaicking chain (2018)

The demosaicking provokes the spatial and color correlation of noise, which is afterwards enhanced by the imaging pipeline. The correct removal previous or simultaneously with the demosaicking process is not usually considered in the literature. We present a novel imaging chain including a denoising of the Bayer CFA and a demosaicking method for image sequences. The proposed algorithm uses a spatio-temporal patch method for the noise removal and demosaicking of the CFA. The experimentation, including real examples, illustrates the superior performance of the proposed chain, avoiding the creation of artifacts and colored spots in the final image.
Intrapartum Oximetry of the Fetus (2007)

Fetal monitoring during labor aims to identify fetal problems which, if uncorrected, may result in morbidity or death. A nonreassuring or abnormal fetal heart rate trace by cardiotocography (CTG) does not necessarily equate with fetal hypoxia and/or acidosis. However, in the absence of more objective data, the use of CTG often results in variable, but inappropriately high, operative delivery rates (forceps, vacuum, or cesarean delivery) for nonreassuring fetal status in many hospitals. The addition of fetal pulse oximetry (FPO) has the potential to improve the assessment of fetal well-being during labor. In this review we consider several aspects of FPO. Several factors, such as sensor to skin contact, uterine contractions, fetal hair, and caput succedaneum, influence the performance and use of FPO. Issues such as clinicians' perspectives of FPO sensor placement, maternal perspectives of FPO during labor, and an economic analysis have all favored FPO. Several randomized controlled trials (RCTs) of FPO reported a reduction in cesarean delivery for nonreassuring fetal status when FPO was added to conventional CTG monitoring, with no difference in overall cesarean delivery rates. One large RCT reported no difference in mode of birth for any indication. Several issues relevant to the future of FPO have been addressed by these RCTs, the major issue being that it makes no difference to cesarean rates. It may be argued that FPO has a valid clinical use in monitoring the fetus with congenital heart block. Additionally, in situations of nonreassuring fetal status and dystocia, FPO may provide the necessary reassurance until adequate resources for cesarean delivery are available.
Pure acoustic P-wave equation of motion in TTI and orthorhombic media (2015)

Summary This paper was withdrawn from the Technical Program by the authors on 1 April 2015. Due to a technical error, SEG failed to heed the authors’ request that the paper be withdrawn, well before the review and publication processes. This paper has been retracted by SEG on behalf of the authors on 15 September 2015. Thus, the paper was mistakenly accepted and published online for the 2015 SEG Annual Meeting but officially withdrawn prior to presentation.
Hyperhomocysteinemia and the risk for vascular disease in hemodialysis patients. (1995)

The objective of this study was to examine if hyperhomocysteinemia is associated with occlusive vascular disease in hemodialysis patients. The study design included risk factor analysis and determination of serum homocysteine in hemodialysis patients. Fifty chronic uremic patients on regular hemodialysis treatment were studied. Twenty-four patients had coronary, cerebral, or peripheral signs of occlusive vascular disease. Cerebral vascular disease was diagnosed by computed tomography, arterial angiography, or Doppler sonography of the carotid and vertebral arteries. Coronary vascular disease was diagnosed by documented history of myocardial infarction or by coronary angiography. The diagnosis of peripheral vascular disease was established by angiography of the lower limb arteries. In all control patients, Doppler sonography of the carotid, vertebral, and lower limb arteries and thallium-201 exercise imaging were without pathologic results. Measurements included blood pressure, body mass index, smoking behavior, serum homocysteine (measured by gas chromatography/mass spectrometry), serum total, low-density lipoprotein, and high-density lipoprotein cholesterol, lipoprotein (a), triglycerides, and plasma fibrinogen. In a stepwise multiple logistic regression analysis, high serum homocysteine was significantly associated with occlusive arterial disease (R = 0.23; P = 0.031). Furthermore, hypertension (R = 0.18; P = 0.058), but not serum total, low-density lipoprotein, and high-density lipoprotein cholesterol, lipoprotein (a), triglycerides, diabetes mellitus, body mass index, plasma fibrinogen, and smoking behavior, was significantly associated with atherosclerosis. Our results support the hypothesis that hyperhomocysteinemia is an independent risk factor for vascular disease in hemodialysis patients.
Phonon-assisted transition rates I. Optical-phonon-assisted hopping in solids (1975)

Abstract An extensive calculation of the optical-phonon-assisted transition rates for non-adiabatic electronic hopping motion in a solid is presented. Holstein's Molecular Crystal Model is used as a basis for study and the computation involves no restrictions on either the magnitude of the electron-lattice coupling strength, the temperature, or the difference between the electronic energies of the initial and final sites. In the strong-coupling small-polaron régime, the jump rates, associated d.c. conductivity, a.c. conductivity, and electric-field dependence of the d.c. conductivity, for a crystal are all calculated. These transport properties manifest qualitatively distinct behaviours corresponding to whether the temperature is above or well below the optical-phonon temperature. In the low-temperature régime the energy-conserving processes which involve the absorption of the minimum amount of vibrational energy provide the dominant contribution to the thermally activated jump rates. At sufficiently high temperatures multiphonon processes dominate the transition rate; the high-temperature jump rates are also activated, albeit with a different activation energy than that which characterizes the low-temperature régime. In the complementary weak-coupling régime, the jump rate is characterized by the dominance of those processes which involve the absorption or emission of the minimum number of phonons consistent with the requirements of energy conservation. Once again two distinct temperature domains manifest themselves: a low-temperature, thermally activated, régime and a high-temperature non-activated régime. Finally, it is shown that, while optical-phonon-assisted transition rates are well defined for a three-dimensional model, divergences will occur for a linear chain (at ω = 0) and for a planar model (at the optical phonon frequency). The calculations in this article bring together many of the results previously obtained for special cases into a single framework and reveal a number of new considerations. The article is the first of two, the second dealing with acoustic-phonon-assisted hopping.
A research on tetrodotoxin purification (2010)

On the basis of tetrodotoxin's property,we removed lipid and protein from fugu's entrails,and then purified tetrodotoxin by activated carbon adsorption,cation interchange,sieve chromatography,and ethanol precipitation assay.This technique did no harm to operation staff and had advantage of volume production and production cost.The tetrodotoxin produced by this technique can meet various demands for application and the technique will be feasible assay for commercial tetrodotoxin process.