gebhart/patrepeval huggingface dataset:
Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells (2011)

Atopic asthma is a chronic disease of the airways that has taken on epidemic proportions in the industrialized world. The increase in asthma rates has been linked epidemiologically to the rapid disappearance of Helicobacter pylori, a bacterial pathogen that persistently colonizes the human stomach, from Western societies. In this study, we have utilized mouse models of allergic airway disease induced by ovalbumin or house dust mite allergen to experimentally examine a possible inverse correlation between H. pylori and asthma. H. pylori infection efficiently protected mice from airway hyperresponsiveness, tissue inflammation, and goblet cell metaplasia, which are hallmarks of asthma, and prevented allergen-induced pulmonary and bronchoalveolar infiltration with eosinophils, Th2 cells, and Th17 cells. Protection against asthma was most robust in mice infected neonatally and was abrogated by antibiotic eradication of H. pylori. Asthma protection was further associated with impaired maturation of lung-infiltrating dendritic cells and the accumulation of highly suppressive Tregs in the lungs. Systemic Treg depletion abolished asthma protection; conversely, the adoptive transfer of purified Treg populations was sufficient to transfer protection from infected donor mice to uninfected recipients. Our results thus provide experimental evidence for a beneficial effect of H. pylori colonization on the development of allergen-induced asthma.
Recent advances in the diagnosis and management of infection in the organ transplant recipient. (2000)

Infection remains a significant cause of morbidity and mortality in organ transplant patients, with significant infection being found in more than half of these individuals posttransplant. The most important principles of patient treatment are prevention, early diagnosis, and specific therapy. The nature of the antimicrobial therapy required both for infection prevention and treatment is closely linked to the immunosuppressive therapy being administered. A particular challenge in the transplant patient is that the antiinflammatory effects of antirejection therapy tend to obscure the manifestations of infection until relatively late in the disease process, thus putting particular emphasis on more aggressive diagnostic approaches-imaging procedures, biopsy, and new techniques for microbial detection (antigen and DNA detection). Antimicrobial therapy can be administered in three ways: therapeutically, prophylactically, and preemptively. Particularly given the propensity for adverse interactions between antimicrobial agents and cyclosporine and tacrolimus, there is a particular emphasis on prophylactic and preemptive use of antimicrobials.
The Immunologically Protective P-4 Antigen ofLeishmania Amastigotes (2000)

The purified membrane-associated Leishmania pifanoi amastigote protein P-4 has been shown to induce protective immunity against infection and to elicit preferentially a T helper 1-like response in peripheral blood mononuclear cells of patients with American cutaneous leishmaniasis. As this molecule is potentially important for future vaccine studies, the L. pifanoi gene encoding the P-4 membrane protein was cloned and sequenced. Southern blot analyses indicate the presence of six tandemly arrayed copies of the P-4 gene in L. pifanoi; homologues of the P-4 gene are found in all other species of the genus Leishmania examined. DNA-derived protein sequence data indicated an identity to the P1 zinc-dependent nuclease of Penicillium citrinum (20.8%) and the C-terminal domain of the 3' nucleotidase of Leishmania donovani (33.7%). Consistent with these sequence analyses, purified L. pifanoi P-4 protein possesses single strand nuclease (DNA and RNA) and phosphomonoesterase activity, with a preference for UMP > TMP > AMP >> CMP. Double-labeling immunofluorescence microscopic analyses employing anti-binding protein antibodies revealed that the P-4 protein is localized in the endoplasmic reticulum of the amastigote. Northern blot analyses indicated that the gene is selectively expressed in the intracellular amastigote stage (mammalian host) but not in the promastigote stage (insect) of the parasite. Based upon its subcellular localization and single-stranded specific nuclease activity, possible roles of the P-4 nuclease in the amastigote in RNA stability (gene expression) or DNA repair are discussed.
Social recommendation model based on user interaction in complex social networks (2019)

The user interaction in online social networks can not only reveal the social relationships among users in e-commerce systems, but also imply the social preferences of a target user for recommendation services. However, the current research has rarely explored the impact of social interaction on recommendation performance, especially now that recommender systems face increasing challenges and suffer from poor efficiency due to social data overload. Therefore, applied research on user interaction has become increasingly necessary in the field of social recommendation. In this paper, we develop a novel social recommendation method based on the user interaction in complex social networks, called the SRUI model, to present a basis for improving the efficiency of the recommender systems. Specifically, a weighted social interaction network is first mapped to represent the interactions among social users according to the gathered information about historical user behavior. Thereafter, the complete path set is mined by the complete path mining (CPM) algorithm to find social similar neighbors with tastes similar to those of the target user. Finally, the social similar tendencies of the users on the complete paths are obtained to predict the final ratings of items through the SRUI model. A series of experimental results based on two real public datasets show that our approach performs better than other state-of-the-art methods in terms of recommendation performance.
Synthesis of multiplier-less FIR filters with minimum number of additions (1995)

Abstract: In this paper we present optimizing transformations to minimize the number of additions+subtractions in both the direct form (/spl Sigma/ A/sub i/X/sub n-i/ based) and its transposed form (Multiple Constant Multiplication based) implementation of FIR filters. These transformations are based on the iterative elimination of 2-bit common subexpressions in the coefficients binary representations. We give detailed description of the algorithms and present results for eight low pass FIR filters with the number of coefficients ranging from 16 to 128. The results show upto 35% reduction in the number of additions+subtractions to implement /spl Sigma/ A/sub i/X/sub n-i/ based FIR filter structures and upto 38% reduction to implement MCM based structures.
[Quantifying retinal capillary circulation using the scanning laser ophthalmoscope]. (1990)

The quantitative picture analysis of video fluorescein angiograms allows one to evaluate retinal hemodynamics. However, this method does not permit us to quantify the retinal capillary perfusion. Now, for the first time, we are able to quantify capillary bloodflow directly and objectively by means of scanning laser ophthalmoscopy. Even the measurement of the bloodflow velocity in all capillaries is now possible. Using digital frame-to-frame picture analysis of digital recordings, bloodflow velocities can be measured on the basis of the movement of dye boluses.
Quantizing nanolaminates as versatile materials for optical interference coatings (2020)

In this paper, the theoretical foundation of quantizing nanolaminates is explained, and the dependence of the optical band gap on quantum-well thickness is demonstrated. The production is investigated by applying molecular dynamics growth simulation and by correlating the results with layers deposited by ion beam sputtering and atomic layer deposition. The properties of manufactured nanolaminates are then compared to the theoretical behavior, and good agreement is found.
Design and implementation of CAN bus protocol for monitoring vehicle parameters (2016)

CAN bus is a serial bus protocol used in most automotive industries. Recently, more attention on the CAN bus network application and wireless transmission bus carrying technology. CAN bus technology is adopted in modern vehicles to reduce the wiring harness and controls the vehicle using electronics system. In this paper, CAN bus protocol is implemented using a single board computer (SBC) and accessed the vehicle parameters remotely. Raspberry Pi is used as SBC which has a high performance processor used to increase speed ability. The presented work concentrate on the communication between three nodes using a CAN bus and how to access modern vehicle ECU parameters using OBD II connector. The paper is described further set up of CAN device using Linux software.
Lack of specificity of current anti-digoxin antibodies, and preparation of a new, specific polyclonal antibody that recognizes the carbohydrate moiety of digoxin. (1985)

Current immunoassays for digoxin do not distinguish digoxin from its glycosidic metabolites. We have synthesized a novel digoxin/bovine serum albumin conjugate via reductive ozonolysis of the lactone ring such that the carbohydrate moiety of digoxin remains intact. Antibodies raised against this conjugate show minimal cross reactivity to digoxigenin, bisdigitoxide, monodigitoxide, digoxigenin, and digitoxin. With this antibody, digoxin can be measured in the presence of these metabolites.
Magnetoplasticity (2005)

Abstract Magnetocrystalline anisotropy and twinned microstructure are at the origin of the appreciable magnetic-field-induced strains found in some ferromagnetic thermoelastic martensites. The change of magnetization across the twinning plane leads to a force on the twinning dislocations when a magnetic field is applied. The sensitivity of this basic microscopic mechanism not only to crystallographic and magnetic properties of the material, but also to microstructural details, leads to a large variance in the macroscopically attainable magnetic-field-induced strains, while the maximum strain is fixed for any given martensite structure. The magnetic-field-induced deformation of Ni–Mn–Ga single crystals was studied in uniaxial (“static”) and rotating (“dynamic”) magnetic fields. The spatial and orientational distribution of martensite domains, twin thickness and mutual interactions between twinning dislocations all contribute to the macroscopic result.
Thin film active matrix organic electroluminescent display development (2002)

An active organic electroluminescent display is being developed in a university environment. The device is a 64/spl times/32 pixel array. Each pixel consists of an organic electroluminescent (EL) diode integrated with a poly-silicon thin film transistors (TFT). This paper describes the design, the layout, the fabrication process, and characteristics of the thin film transistors used. A novel structure of high voltage vertical silicon thin film transistor has been discovered. The characteristics of these transistors are briefly presented here. The electric and spectral EL of the stand alone organic diodes are also shown here.
Building envelope shape design using a shape grammar-based parametric design system integrating energy simulation (2011)

The envelope shape is considered the most salient design characteristic in a building and also impacts its energy performance. And although energy efficiency in design is gaining momentum, the value of architectural attributes should not be underestimated. Design rules of thumb are useful guidelines to achieve better energy performance but they do not substitute energy simulation results, particularly in more complex projects. However, in the early design stages, when the envelope shape is defined, energy information is normally inexistent, due to modeling for energy simulation being a time-consuming task, frequently overlooked at this phase, when the design is still uncertain regarding many parameters. This paper presents a methodology to assist design decisions regarding the building envelope shape taking into account its implications on the energy performance of the building. Basically, this methodology involves a design system, an editable (flexible) system to generate various envelope shape designs, with integrated energy simulation, to calculate the energy consumption values of each generated design. Design systems encoded into shape grammars are more adequate for the architecture field, given their ability to guarantee stylistic coherence, but they are hard to implement. This methodology converts a grammar into a parametric design system and is illustrated with its application to the grammar for Frank Lloyd Wright's prairie houses. Output examples of the application are also presented. Results show the validity of the proposed methodology and the addition of optimization techniques is identified as the obvious next step.
Food matters: how the microbiome and gut–brain interaction might impact the development and course of anorexia nervosa (2017)

Anorexia nervosa (AN) is one of the most common chronic illnesses in female adolescents and exhibits the highest mortality risk of all psychiatric disorders. Evidence for the effectiveness of psychotherapeutic or psychopharmacological interventions is weak. Mounting data indicate that the gut microbiome interacts with the central nervous system and the immune system by neuroendocrine, neurotransmitter, neurotrophic and neuroinflammatory afferent and efferent pathways. There is growing evidence that the gut microbiota influences weight regulation and psychopathology, such as anxiety and depression. This article reviews how the gut-brain interaction may impact the development and course of AN. A "leaky gut", characterized by antigens traversing the intestinal wall, was demonstrated in an animal model of AN, and could underlie the low-grade inflammation and increased risk of autoimmune diseases found in AN. Moreover, starvation has a substantial impact on the gut microbiome, and diets used for re-nutrition based on animal products may support the growth of bacteria capable of triggering inflammation. As there is currently no empirically derived agreement on therapeutic re-nourishment in AN, this review discusses how consideration of gut-brain interactions may be important for treatment regarding the determination of target weight, rapidity of weight gain, refeeding methods and composition of the diet which might all be of importance to improve long-term outcome of one of the most chronic psychiatric disorders of adolescence.
Second lung cancers in patients successfully treated for lung cancer. (1997)

The rate of developing second lung cancers and other aerodigestive tumors in patients who have been treated for both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) is approximately 10-fold higher than other adult smokers. The risk of second lung cancers in patients surviving resection of NSCLC is approximately 1% to 2% per year. The series reported show that the patients who develop second NSCLCs tend to have early-stage NSCLC (predominantly stage I and II). The survival of patients after the second resection of lung cancer is similar to that of patients presenting with initial NSCLC. The risk of second lung cancers in patients surviving SCLC is 2% to 14% per patient per year and increases two- to seven-fold with the passage of time from 2 to 10 years. The risk of second lung cancers in patients treated for SCLC appears to be higher than that found in patients with NSCLC who were treated only with surgical resection. In addition, the chances of successful resection of second primary NSCLCs in patients who were treated for SCLC is much less than that for patients with metachronous lung cancers after an initial NSCLC. Patients treated for SCLC who continue to smoke cigarettes increase their rate of developing second lung cancers. The contribution of chest radiation and chemotherapy administration to the risk of developing second lung tumors remain to be defined but may be responsible for some of the increased risk in patients treated for SCLC compared to patients undergoing a surgical resection for NSCLC.
Wavelength conversion in modulated coupled-resonator systems and their design via an equivalent linear filter representation (2014)

We propose wavelength converters based on modulated coupled resonators that achieve conversion by matching the modulation frequency to the frequency splitting of the supermodes of the unmodulated system. Using temporal coupled-mode theory, we show that these time-variant systems have an equivalent linear, time-invariant filter representation that simplifies the optimal engineering of design parameters for realistic systems. Applying our model to carrier plasma-dispersion modulators as an example implementation, we calculate conversion efficiencies between -5.4 and -1.7 dB for intrinsic quality factors of 10(4)-10(6). We show that the ratio of the resonance shift to the total linewidth is the most important parameter when determining conversion efficiency. Finally, we discuss how this model can be used to design devices such as frequency shifters, widely tunable radio frequency oscillators, and frequency combs.
The Mariposa distributed database management system (1996)

article Free Access Share on The Mariposa distributed database management system Author: Jeff Sidell View Profile Authors Info & Claims ACM SIGMOD RecordVolume 25Issue 4Dec. 1996 pp 76–80https://doi.org/10.1145/245882.245906Published:01 December 1996Publication History 0citation162DownloadsMetricsTotal Citations0Total Downloads162Last 12 Months7Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Erythropoietic Response and Outcomes in Kidney Disease and Type 2 Diabetes (2010)

A poor initial hematopoietic response to darbepoetin alfa was associated with an increased subsequent risk of death or cardiovascular events as doses were escalated to meet target hemoglobin levels. Although the mechanism of this differential effect is not known, these findings raise concern about current target-based strategies for treating anemia in patients with chronic kidney disease. (Funded by Amgen; ClinicalTrials.gov number, NCT00093015.)
Dressed to Kill (2010)

Abstract This chapter discusses how female bravery is represented by the acts of sewing and embroidery. When men go off to war, women are left at home doing the domestic chores. But during the regime of Juan Manuel de Rosas, women began to take active political roles such as sewing the uniforms or flags for men, or with men planning for war. In spite of the women’s growing political participation, violence and manipulation are still visible. This chapter then traces the political gender-specific assignments within the Argentine history, presenting women with the least significance in the Argentine-Spanish society.
Experiments on real-time 1-Gb/s packet transmission using MLD-based signal detection in MIMO-OFDM broadband radio access (2006)

This paper presents experimental results on real-time packet transmission of greater than 1 Gb/s using 4-by-4 multiple-input-multiple-output (MIMO) multiplexing and maximum-likelihood detection (MLD)-based signal detection with a decreased level of computational complexity in orthogonal frequency-division multiplexing (OFDM) radio access. We apply our previous algorithm called adaptive selection of surviving symbol replica candidates (ASESS) based on the maximum reliability in MLD employing QR decomposition and the M-algorithm (QRM-MLD) to reduce the extremely high level of computational complexity in the conventional MLD. The experimental results using multipath fading simulators are in good agreement with the computer simulation results. The loss in the required received signal energy per bit-to-background noise power spectrum density ratio (E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> /N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) is suppressed to within approximately 1-2 dB. Therefore, through experiments, we demonstrate that the QRM-MLD employing ASESS is very beneficial in reducing the influence of hardware implementation loss, as well as in decreasing the required received E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> /N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> . We further show that the extremely high-speed real-time packet transmission of greater than 1 Gb/s in a 100-MHz channel bandwidth (i.e., 10 bit/s/Hz) is achieved at the average received E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> /N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> per receiver antenna of approximately 12 dB using 16QAM modulation and turbo coding with the coding rate of 8/9 in 4-by-4 MIMO multiplexing
RELATIONSHIPS BETWEEN ENGINEERING CHARACTERISTICS AND MATERIAL PROPERTIES OF HIGH STRENGTH- HIGH PERFORMANCE CONCRETE (2003)

It is generally accepted that when considering relationships between microstructure, mechanical properties and durability performance, the most significant microstructural component of concrete is the pore structure. To better understand how material composition and microstructrural modifications determine the high strength concrete structrural performance, the relationships between porosity and different engineering properties including compressive strength, conductivity, autogenous and total shrinkage were evaluated. This paper illustrates the effect of silica fume, ultra fine fly ash and ground granulated blast furnace slag on the porosity, strength and conductivity of high strength-high performance concrete, and investigates the shrinkage behavior and cracking potential of these high performance mixes. The drawn correlations between porosity, conductivity and shrinkage indicate that optimizing the microstructure can be used to improve autogenous shrinkage and minimize shrinkage cracking without affecting mechanical and durability properties. INTRODUCTION EXPERIMENTAL PROGRAM EXPERIMENTAL RESULTS AND DISCUSSION CONCLUSIONS ACKNOWLEDGMENTS REFERENCES