gebhart/patrepeval huggingface dataset:
Polymethyl methacrylate (PMMA)–bismuth ferrite (BFO) nanocomposite: low loss and high dielectric constant materials with perceptible magnetic properties (2014)

Herein, poly(methyl methacrylate)-bismuth ferrite (PMMA-BFO) nanocomposites were successfully prepared by an in situ polymerization method for the first time. Initially, the as prepared bismuth ferrite (BFO) nanoparticles were dispersed in the monomer, (methyl methacrylate) by sonication. Benzoyl peroxide was used to initiate the polymerization reaction in ethyl acetate medium. The nanocomposite films were subjected to X-ray diffraction analysis (XRD), (1)H NMR, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), infrared spectroscopy (IR), dielectric and magnetic characterizations. The dielectric measurement of the nanocomposites was investigated at a frequency range of 10 Hz to 1 MHz. It was found that the nanocomposites not only showed a significantly increased value of the dielectric constant with an increase in the loading percentage of BFO as compared to pure PMMA, but also exhibited low dielectric loss values over a wide range of frequencies. The values of the dielectric constant and dielectric loss of the PMMA-BFO5 (5% BFO loading) sample at 1 kHz frequency was found be ~14 and 0.037. The variation of the ferromagnetic response of the nanocomposite was consistent with the varying volume percentage of the nanoparticles. The remnant magnetization (Mr) and saturation magnetization (Ms) values of the composites were found to be enhanced by increasing the loading percentage of BFO. The value of Ms for PMMA-BFO5 was found to be ~6 emu g(-1). The prima facie observations suggest that the nanocomposite is a potential candidate for application in high dielectric constant capacitors. Significantly, based on its magnetic properties the composite will also be useful for use in hard disk components.
Transforming consumer health informatics through a patient work framework: connecting patients to context (2014)

Designing patient-centered consumer health informatics (CHI) applications requires understanding and creating alignment with patients' and their family members' health-related activities, referred to here as 'patient work'. A patient work approach to CHI draws on medical social science and human factors engineering models and simultaneously attends to patients, their family members, activities, and context. A patient work approach extends existing approaches to CHI design that are responsive to patients' biomedical realities and personal skills and behaviors. It focuses on the embeddedness of patients' health management in larger processes and contexts and prioritizes patients' perspectives on illness management. Future research is required to advance (1) theories of patient work, (2) methods for assessing patient work, and (3) techniques for translating knowledge of patient work into CHI application design. Advancing a patient work approach within CHI is integral to developing and deploying consumer-facing technologies that are integrated with patients' everyday lives.
Femtosecond laser filaments and aerodynamics (2013)

Summary form only given. A propagating femtosecond laser pulse will result in a filament, when an ultrashort laser pulse with sufficient peak power undergoes self-focusing and consequently ionizes the molecules of air. A dynamic balance between diffraction, self-focusing, and plasma defocusing ensures that the laser pulse propagates over many Rayleigh lengths without significant diffraction. The laser filament is furthermore characterized by supercontinuum generation that can be attributed to self-phase modulation, X-wave formation and four-wave mixing [1]. Spatial and temporal focusing techniques have been numerically explored in [2] to control the supercontinuum generation that accompanies a laser filament. Temporal focusing, by adjusting the chirp of a broadband laser pulse, has been demonstrated in [3] to achieve optimal ionization at long distances.
Learnings about the complexity of extracellular tau aid development of a blood‐based screen for Alzheimer's disease (2018)

The forms of tau in CSF and plasma are distinct, but in each specimen type, the levels of certain fragments are increased in AD. Measurement of plasma NT1 tau should be aggressively pursued as a potential blood-based screening test for AD/AD-MCI.
Disruption of OCT4 Ubiquitination Increases OCT4 Protein Stability and ASH2L-B-Mediated H3K4 Methylation Promoting Pluripotency Acquisition (2018)

The protein level of OCT4, a core pluripotency transcription factor, is vital for embryonic stem cell (ESC) maintenance, differentiation, and somatic cell reprogramming. However, how OCT4 protein levels are controlled during reprogramming remains largely unknown. Here, we identify ubiquitin conjugation sites of OCT4 and report that disruption of WWP2-catalyzed OCT4 ubiquitination or ablation of Wwp2 significantly promotes the efficiency of pluripotency induction from mouse embryonic fibroblasts. Mechanistically, disruption of WWP2-mediated OCT4 ubiquitination elevates OCT4 protein stability and H3K4 methylation level during the reprogramming process. Furthermore, we reveal that OCT4 directly activates expression of Ash2l-b, and that ASH2L-B is a major isoform of ASH2L highly expressed in ESCs and required for somatic cell reprogramming. Together, this study emphasizes the importance of ubiquitination manipulation of the reprogramming factor and its interplay with the epigenetic regulator for successful reprogramming, opening a new avenue to improve the efficiency of pluripotency induction.
Preexisting Levels of CD4 T Cells Expressing PD-1 Are Related to Overall Survival in Prostate Cancer Patients Treated with Ipilimumab (2015)

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blockade can induce tumor regression and improved survival in cancer patients. This treatment can enhance adaptive immune responses without an exogenous vaccine, but the immunologic biomarkers associated with improved clinical outcome in cancer patients are not fully established. A phase Ib trial in patients with metastatic, castration-resistant prostate cancer was performed combining ipilimumab with sargramostim (GM-CSF). In addition to evaluating ipilimumab dose, patients were followed clinically for response and overall survival, and for immunomodulation of circulating T cells. PSA declines of ≥50% and radiographic responses were observed at doses of ≥3 mg/kg/dose. Timing of clinical responses could be either immediate or delayed. Durable responses were also observed off treatment. A subset of patients experienced long-term survival with or without objective clinical responses. The relationship between T-cell phenotype in peripheral blood and overall survival was examined retrospectively. We found that the treatment induced an increase in the levels of CD4(+) effector T (Teff) cells, regulatory T cells, PD-1(+) CD4 Teff cells, and PD-1(+) CD8 T cells. However, these increased levels were not associated with overall survival. Instead, low pretreatment baseline levels of PD-1(+) CD4 Teff cells were found to correlate with longer overall survival. Furthermore, baseline levels of PD-1(+) CD4 Teff cells from patients with shorter overall survival were higher than from cancer-free male control subjects. These results suggest that preexisting expression of immunologic checkpoint marker PD-1 on CD4 Teff cells may help identify patients that may benefit from ipilimumab treatment.
Dissimilar effect of perming and bleaching treatments on cuticles: Advanced hair damage model based on elution and oxidation of S100A3 protein (2005)

Hair treatment chemicals induce sudden and severe hair damage. In this study, we examined cuticles from untreated, permed, and bleached hair that were mechanically discriminated by shaking in water. Both perming and bleaching treatments are prone to easily delaminate cuticles. Confocal microscopy revealed that the cuticles of permed hair were delaminated with larger pieces than untreated ones. On the other hand, the cuticles of bleached hair tend to fragment into small peptides. At the minimum concentration of thioglycolate required to elute S100A3 protein from the endocuticle into the reductive permanent waving lotion, enlarged delaminated cuticle fragments were observed. Although S100A3 is retained in bleached hair, S100A3 is irreversibly oxidized upon bleaching treatment. It is likely that the oxidative cleavage of disulfide bonds between cuticle-constituting proteins, including S100A3, results in the fragile property of cuticles. Here we present a more comprehensive model of hair damage based on a diverse mechanism of cuticle delamination.
Context-aware real-time tracking in sparse representation framework (2013)

Real-time object tracking is a difficult task in unconstrained environment due to the variations in factors such as pose, size, illumination, partial occlusion and motion blur. In this paper, we propose a novel approach based on local sparse representation for robust object tracking to address the above issues. In the proposed approach, a search window, including the object and the surrounding information is used to create dictionary of overlapping patches. This context-based method is used to discriminate the confusing patches of the foreground with those in the background. Candidate patches are sparsely represented in the dictionary and foreground/background classification is done by computing the confidence map based on the distribution of sparse coefficients. Pyramidal structure of the object window that depicts object at different scales is used to create a dictionary that can handle scale changes. Object is localized by seeking the mode of the confidence map. A suitable dictionary update strategy is used to alleviate the drift problem during tracking. Numerous experiments on challenging videos demonstrate that the proposed tracker outperforms several state-of-the-art algorithms. The proposed approach tracks at a high processing speed and is suitable for real-time applications.
CATALYST: planning layer directives for effective design closure (2013)

For the last several technology generations, VLSI designs in new technology nodes have had to confront the challenges associated with reduced scaling in wire delays. The solution from industrial back-end-of-line process has been to add more and more thick metal layers to the wiring stacks. However, existing physical synthesis tools are usually not effective in handling these new thick layers for design closure. To fully leverage these degrees of freedom, it is essential for the design flow to provide better communication among the timer, the router, and different optimization engines. This work proposes a new algorithm, CATALYST, to perform congestion- and timing-aware layer directive assignment. Our flow balances routing resources among metal stacks so that designs benefit from the availability of thick metal layers by achieving improved timing and buffer usage reduction while maintaining routability. Experiments demonstrate the effectiveness of the proposed algorithm.
Synthesis and Antibacterial Evaluation of Novel Water-Soluble Organic Peroxides (1998)

A set of new water-soluble organic peroxides has been synthesized and evaluated for in vitro antibacterial activity as part of an effort to develop new antibacterial agents for the treatment of acne vulgaris. The water solubility of these new dialkyl peroxides and peroxyesters was achieved by incorporating either a quaternary ammonium group or a polyethylene glycol moiety. These peroxides are effective against both gram-positive and gram-negative bacteria and have a prolonged activity compared to that of benzoyl peroxide and other peroxide-type antiseptic agents. Among them 4-[[(tert-butylperoxy)carbonyl]benzyl]triethylammonium chloride and [10-(tert-butylperoxy)decyl]trimethylammonium bromide have the broadest antimicrobial spectrums. We have shown that the oxidizing properties of the dioxy group of these compounds are responsible for their antibacterial activities.
Regulated Chlorophyll Degradation in Spinach Leaves during Storage (1991)

Degradation of chlorophyll in spinach (Spinacia olearacea L. cv. Hybrid 612) appeared to be regulated through the peroxidase-hydrogen peroxide pathway, which opens the porphyrin ring, thus resulting in a colorless compound. This conclusion was arrived at from the analysis of chlorophylls (Chls) and their metabolizes by HPLC and of enzyme activities catalyzing the degradative reactions. Chls decreased at 25C but not at 1C. The chlorophyll oxidase pathway was not active, as noted by the lack of accumulation of a reaction product named Chl a-1. Lipid peroxidation increased with storage, but the products of the reaction. did not degrade chlorophyll, as noted by the lack of increase in Chl a-1. Chlorophyllase activity increased, but chlorophyllide, the expected product of the reaction, changed minimally during senescence. Ethylene at 10 ppm did not alter the pathway that degraded chlorophyll in spinach.
Natural Oils as Lubricants (2005)

The last decade has seen a slow but steady move toward the use of “environmentally friendly” or more readily biodegradable lubricant fluids. Biodegradability has become one of the most important design parameters both in the selection of the base fluid and in the overall formulation of the finished lubricant. By more readily biodegradable it is meant that the fluids, using standard methods and assays, are converted from the lubricating fluids to lower molecular weight components that have essentially no environmental impact. The rate at which lubricants, and other chemicals or additive components, biodegrade is related to their chemical structure. Their chemical structure affects their properties, many of which affect performance in the various tests for biodegradability. For example, water solubility is critical in some tests for biodegradability, and toxicity is very important, because if the lubricant is toxic and reduces the organism population, then this directly and negatively impacts the process of biodegradation.
Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries (2017)

As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue. Therefore, the present review is focused on the efforts that have been made over the past years to find peptides possessing wound-healing properties, towards the development of new and effective wound care treatments for diabetic foot ulcers and other skin and soft tissue infections.
A Technique for Predicting Large Signal Performance of a GaAs MESFET (2005)

A method is described for accurately predicting nonlinear microwave performance of GaAs MESFET devices. The method utilizes time-domain analysis and is based upon experimentally characterized bias-dependence of device circuit model elements. Precise predictions are made of fundamental and harmonic power levels up to 6 dB of gain compression.
Phosphatidylinositol 3′-Kinase and SH2-Containing Inositol Phosphatase (SHIP) Are Recruited by Distinct Positive and Negative Growth-Regulatory Domains in the Granulocyte Colony-Stimulating Factor Receptor (1998)

Abstract Activation of both positive and “negative” or anti-proliferative signals has emerged as a common paradigm for regulation of cell growth through cell surface receptors that regulate immune responses. SHP-1 and -2 and the novel 5′-inositol phosphatase SHIP have recently been shown to function as growth inhibitory molecules in immune receptor signaling. In the current study, we have identified distinct regions in the granulocyte colony-stimulating factor receptor (G-CSFR) distal to the conserved box 2 motif necessary for mitogenesis, which exert positive and negative influences on growth signaling in Ba/F3 pro-B lymphoid cells. The region spanning amino acids 682 to 715 mediates activation of phosphatidylinositol 3′(PI3)-kinase. Activation of PI3-kinase leads to inhibition of apoptosis, promotion of cell survival, and enhanced proliferative responses to G-CSF. We show that the region of 98 amino acids in the distal tail of the class I G-CSFR down-modulates proliferative signaling, not only in myeloid cell lines, as previously reported, but also in Ba/F3 cells. This same region recruits SHIP to the signaling cascade through a mechanism involving Shc, with the formation of Shc/SHIP complexes. Our data suggest a model in which PI3-kinase and SHIP coordinately regulate growth signaling through the G-CSFR.
Quantum Strategy: The Interior World of War (2013)

Strategy is often conceived as a practical process of applying means to ends. Using Clausewitz’s observation that the result in war is never final, this essay seeks to challenge this conventional understanding in order to reveal the essential nature of resistance, which in itself contains lessons and insights for the careful strategist.
Use of pyocin to select a Haemophilus ducreyi variant defective in lipooligosaccharide biosynthesis (1994)

Haemophilus ducreyi, a cause of genital ulcer disease in developing countries, appears to facilitate the heterosexual transmission of the human immunodeficiency virus in Africa. Despite an increase in studies of this gram-negative human pathogen, little is known about the pathogenesis of chancroid. Our studies have shown that the lipooligosaccharides (LOS) of H. ducreyi may play an important role in ulcer formation. Monoclonal antibody and mass spectrometric analyses identified a terminal trisaccharide present on H. ducreyi LOS that is immunochemically similar to human paragloboside. This epitope is present on the LOS of Neisseria gonorrhoeae, and it may be the site of attachment for pyocin lysis. We have used pyocin, produced by Pseudomonas aeruginosa, to select LOS variants with sequential saccharide deletions from N. gonorrhoeae. On the basis of the similarities between N. gonorrhoeae and H. ducreyi LOS, we employed the same technique to determine if H. ducreyi strains were susceptible to pyocin lysis. In this study, we report the generation of a pyocin N-resistant H. ducreyi strain which synthesizes a truncated version of the parental LOS. Further studies have shown that this H. ducreyi variant has lost the terminal LOS epitope defined by monoclonal antibody 3F11. This report demonstrates that H. ducreyi is sensitive to pyocins and that this technique can be used to generate H. ducreyi LOS variants. Such variants could be used in comparative studies to relate LOS structure to biologic function in the pathogenesis of chancroid.
Differential Temperature Sensitivity of Pea Superoxide Dismutases (1992)

The activity of pea (Pisum sativum L.) Cu/Zn and Mn superoxide dismutase isoforms was evaluated across a range of temperatures from 10 to 45°C. Maximal activity of the Cu/Zn and Mn superoxide dismutase isoforms was observed at 10°C. Both cytoplasmic and chloroplast Cu/Zn superoxide dismutases exhibit a reduction in staining intensity with increasing temperatures. Mn superoxide dismutase, however, maintained a relatively constant staining intensity across the range of temperatures evaluated. An unrelated enzyme used as a control, malate dehydrogenase, exhibited the expected increase in staining activity with increasing temperatures. These results describe a unique response of a protection enzyme to temperature.
Optogenetically induced cellular habituation in non-neuronal cells (2020)

Habituation, defined as the reversible decrement of a response during repetitive stimulation, is widely established as a form of non-associative learning. Though more commonly ascribed to neural cells and systems, habituation has also been observed in single aneural cells, although evidence is limited. Considering the generalizability of the habituation process, we tested the degree to which organism-level behavioral and single cell manifestations were similar. Human embryonic kidney (HEK) cells that overexpressed an optogenetic actuator were photostimulated to test the effect of different stimulation protocols on cell responses. Depolarization induced by the photocurrent decreased successively over the stimulation protocol and the effect was reversible upon withdrawal of the stimulus. In addition to frequency- and intensity-dependent effects, the history of stimulations on the cells impacted subsequent depolarization in response to further stimulation. We identified tetraethylammonium (TEA)-sensitive native K+ channels as one of the mediators of this habituation phenotype. Finally, we used a theoretical model of habituation to elucidate some mechanistic aspects of the habituation response. In conclusion, we affirm that habituation is a time- and state-dependent biological strategy that can be adopted also by individual non-neuronal cells in response to repetitive stimuli.
Visualisation of Tensor Time Domain Electromagnetic Data (1995)

Long Offset Time Domain Electromagnetic (LOTEM) measurements traditionally use a single current source. By using a second source, a tensor analysis technique analogous to that used in DC resistivity multiple-source bipole-dipole surveying, is possible. An instantaneous apparent resistivity tensor is defined as the relationship between the time varying (total) electric field and the DC half space current density vectors due to each source. If the sources are dipoles the three coordinate invariant apparent resistivities of the tensor are independent of source orientation. For a uniform half space, one of the invariants is virtually constant in time, deviating from the half space resistivity by a maximum of 6%. This method provides a way in which the complicated data set obtained during a tensor LOTEM survey can be presented in a compact and intelligible form, and has many advantages over conventional methods of analyzing LOTEM data particularly where the resistivity distribution is three dimensional (3D). Results from a 3D resistivity model of an idealized geothermal reservoir and outflow structure are used to illustrate the power of this analysis.
The Effects of Walking and Cycling Computer Workstations on Keyboard and Mouse Performance (2009)

Although active workstations may result in some decrement in performance, their ability to increase daily energy expenditure may make them a feasible solution for workplace inactivity.
Systems Modelling via Resources and Processes: Philosophy, Calculus, Semantics, and Logic (2007)

We describe a programme of research in resource semantics, concurrency theory, bunched logic, and stochastic processes, as applied to mathematical systems modelling. Motivated by a desire for structurally and semantically rigorous discrete event modelling tools, applicable to enterprise-scale as well as component-scale systems, we introduce a new approach to compositional reasoning based on a development of SCCS with an explicit model of resource. Our calculus models the co-evolution of resources and processes with synchronization constrained by the availability of resources. We provide a simple denotational semantics as a parametrization of Abramsky's synchronization trees semantics for SCCS. We also provide a logical characterization, analogous to Hennessy-Milner logic's characterization of bisimulation in CCS, of bisimulation between resource processes which is compositional in the concurrent and local structure of systems. We discuss applications to ideas such as location and access control.