gebhart/patrepeval huggingface dataset:
Automated System for Optimized Calibration of Engine Management Systems (1994)

<div class="htmlview paragraph">Due to the stringent emission standards modern engine concepts require special equipment for reducing exhaust pollutants and minimizing fuel consumption. Usually all those engine functions are managed by an electronic engine control unit (ECU).</div> <div class="htmlview paragraph">A good potential for emission reduction is dependent on a well optimized set of calibration maps, tables and constants, contained in the ECU. The time to evaluate an optimum data design strongly depends on the number of these calibration parameters. With an increasing number of such parameters, there is a need for sophisticated test systems which automatically initiate parameter variations, perform necessary measurements and search for an optimized engine calibration.</div> <div class="htmlview paragraph">VEGA is an automatic optimization system that controls the whole calibration process from the first basic mapping until the final programming of the ECU. It performs much faster and, following exact mathematical algorithms, results in better reproducibility than with manual optimization.</div> <div class="htmlview paragraph">The time required for an automatic operation depends on the Optimization-Algorithm and the chosen parameters. Various results are shown and discussed.</div>
Latest technologies in plate cooling and their benefits in plate production (2008)

With extremely high cooling rates, a combined laminar jet and spray nozzle design cooling facility is the most advanced tool for the evolution of mechanical properties of high-strength steels. The main metallurgical aspects of Accelerated Cooling (ACC) and Direct Quenching (DQ) are presented. Typical plate applications are brought up. Design, engineering and operational aspects of modern cooling facilities are explained. Of particular importance for a homogenous cooling process is a powerful process control featuring advanced process models.
Buffer Layer of PEDOT:PSS/Graphene Composite for Polymer Solar Cells (2010)

High-efficiency polymer solar cells were made with a hydrophilic graphene oxide (GO) doped in poly(ethylene dioxythiophene) (PEDOT)-polystyrene sulfonic acid (PSS) composites using a structure of indium tin oxide/PEDOT:PSS:GO (40 nm)/poly(3-hexylthiophene-1,3-diyl) (P3HT)-[6,6]-phenyl-C61-butyric acid methyl ester (PCBM) (1:0.6, 100 nm)/LiF (1 nm)/Al (70 nm). The energy conversion efficiency eta was enhanced from 2.1 to 3.8% by doping GO into the PEDOT:PSS buffer layer under AM1.5G 100 mW cm(-2) illumination in air. The pre-annealing of GO makes energy conversion efficiency 1.8 times that of the device based on a pristine PEDOT:PSS buffer layer. Because of the low price and ease of preparation, soluble graphene will be a promising buffer layer used in photovoltaic applications. Furthermore, it can be used in other electronic applications.
Multiple Piezoelectric Effect of Piezoelectric Crystal Under Applied Electric Field (2009)

Based on the theory of classical piezoelectricity,the relationship between the generations of multiple piezoelectric effect under applied electric field and boundary conditions was analyzed.The generating process of multiple piezoelectric effect was elaborated and the formulas of secondary direct and tertiary converse piezoelectric effect were deduced.The displacement or voltage generated by primary converse,secondary direct and tertiary converse piezoelectric effect were calculated using coupled-field analysis function in the finite element analysis software ANSYS.Experiments of multiple piezoelectric effect under applied electric field were performed through PZT-5 stack.The experimental result verifies the existence of multiple piezoelectric effect.Experimental data show that voltage and displacement generated by secondary direct and tertiary converse piezoelectric effects respectively have linear relationship with the applied voltage.The simulation and experimental results both prove the accuracy of the theoretical analysis.
Deep sequencing reveals important roles of microRNAs in response to drought and salinity stress in cotton (2014)

Drought and salinity are two major environmental factors adversely affecting plant growth and productivity. However, the regulatory mechanism is unknown. In this study, the potential roles of small regulatory microRNAs (miRNAs) in cotton response to those stresses were investigated. Using next-generation deep sequencing, a total of 337 miRNAs with precursors were identified, comprising 289 known miRNAs and 48 novel miRNAs. Of these miRNAs, 155 miRNAs were expressed differentially. Target prediction, Gene Ontology (GO)-based functional classification, and Kyoto Encyclopedia of Genes and Genomes (KEGG)-based functional enrichment show that these miRNAs might play roles in response to salinity and drought stresses through targeting a series of stress-related genes. Degradome sequencing analysis showed that at least 55 predicted target genes were further validated to be regulated by 60 miRNAs. CitationRank-based literature mining was employed to determinhe the importance of genes related to drought and salinity stress. The NAC, MYB, and MAPK families were ranked top under the context of drought and salinity, indicating their important roles for the plant to combat drought and salinity stress. According to target prediction, a series of cotton miRNAs are associated with these top-ranked genes, including miR164, miR172, miR396, miR1520, miR6158, ghr-n24, ghr-n56, and ghr-n59. Interestingly, 163 cotton miRNAs were also identified to target 210 genes that are important in fibre development. These results will contribute to cotton stress-resistant breeding as well as understanding fibre development.
An Intelligent Scalp Inspection and Diagnosis System for Caring Hairy Scalp Health (2018)

This paper proposes an intelligent scalp inspection and diagnosis system based on the deep learning techniques for caring hair scalp health. The proposed system can automatically recognize the status of the user's scalp. Moreover, we can continuously increase in the number of samples to enhance the accuracy rate by adopting deep learning techniques. The proposed system consists of a scalp detector, an app running on a tablet, and a cloud management platform. The scalp detector will be connected with the tablet via Wi-Fi wireless network. Thus, a scalp photo can be captured via the proposed scalp detector. The scalp photo will be recognized by scalp detector, and the recognized result of the scalp will also be sent and displayed to the tablet. As a result, we can get the quantitative data on the scalp, including bacteria, allergies, dandruff, grease, and hair loss. Moreover. The experimental results showed that the accuracy can be achieved 90.909%.
Sagnac Interferometer Including A Recirculating Ring With An Erbium-doped Fibre Amplifier (2005)

The use of a Sagnac interferometer as an acoustic sensor has recently been demonstrated [1]. One reason for using a Sagnac interferometer is that the path imbalance is zero, such that no interferometric conversion of the source phase noise to intensity noise occurs. The low frequency response of a Sagnac interferometer increases with increasing loop length, and a very long length of fibre is needed to achieve high responsivity for acoustical frequencies. In this paper we present a scheme where we enhance the low frequency response using a recirculating ring within the Sagnac loop, as shown in fig. 1, thereby increasing the effective length of the Sagnac loop. To increase the number of recirculations an erbium-doped fibre amplifier is incorporated in the ring to compensate for both the coupling and the intrinsic losses of the ring. We also present the results of a noise analysis of a recirculating ring including a fibre amplifier, and show that the dominating noise in our sensor is the beat noise between the signal and the spontaneous emission produced by the fibre amplifier.
On the Role of the Carboxyl Group of Sialic Acid in Binding of Cholera Toxin to the Receptor Glycosphingolipid, GM11 (1994)

The carboxyl group of the natural cholera toxin receptor, the ganglioside GM1, Gal beta 1-3GalNAc beta 1-4(NeuAc alpha 2-3)Gal beta 1-4Glc beta 1-Cer, has been converted to a number of C(1)-amides of NeuAc. The binding of cholera toxin B-subunit to these derivatives was monitored by exposing the modified glycolipids, on solid phases, to radiolabeled toxin. Binding was obtained, although substantially reduced, with the amide and to a lesser extent with the benzylamide and also the C(1)-alcohol. In the assay system used, the methyl-, ethyl-, or propylamides did not bind. It was concluded that the hydrogen bonding capacity of a carboxyl or amide group is needed for strong binding. This is in agreement with the recently published crystal structure of the B-subunit in complex with the GM1 pentasaccharide.
Abstract 5324: Selective Inhibition of HDAC6 regulates preferential cytotoxicity in cancer cells by modulating p53 and Hsp90 stability (2015)

Abstract A HDAC6-selective inhibitor is a promising new therapeutic agent for cancer treatment, but its precise mechanisms of actions are not well understood. In particular, the relevance of p53 for HDAC6 inhibitor-induced effects has not been fully elucidated. Here, we show that a γ-lactam based HDAC inhibitor A452 selectively inhibits HDAC6 catalytic activity in vivo and in vitro. A452 causes cell death as well as growth inhibition of transformed cells not observed in normal cells. A452 exhibits differential cytotoxicity for wild-type (wt) and mutant p53 (mutp53) human colorectal cancer cells. Interestingly, A452 shows different mechanisms of action of modulating p53 in cancer cells. A452 increases wtp53 by destabilizing MDM2 and MDMX. In contrast, A452 causes mutp53 destabilization by inhibiting complex formation between Hsp90 and hyperstable mutp53, which is a hallmark of p53 mutation and cancer cell-specific. A452 also chemosensitizes cancer cells differing in p53 status for chemotherapy due to its ability to degrade mutp53 and stabilize wtp53. Intriguingly, acetylation of Hsp90 by A452 results in its degradation as well as inactivation of its chaperone activity. Furthermore, A452 effectively suppresses cell migration and invasion. These results demonstrate that A452 is a specific HDAC6 inhibitor and requires for p53 and Hsp90 for inducing anticancer action. Therefore, these results suggest that therapeutic targeting of HDAC6 may represent a new way to treat cancers expressing mutant forms of p53. Citation Format: So Hee Kwon. Selective Inhibition of HDAC6 regulates preferential cytotoxicity in cancer cells by modulating p53 and Hsp90 stability. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5324. doi:10.1158/1538-7445.AM2015-5324
스트레스반응에 향정신성 약물이 미치는 효과 (1988)

본 연구는 심리적 갈등의 스트레스자극이 신체·행동변화 및 위궤양 발생에 미치는 효과를 검토하고, 이와같은 갈등조건에서 초래된 신체·행동변화 및 위궤양에 대한 향정신성 약물의 효과를 검토하고자 하였다. 실험 결과, 심리적 갈등조건이 제시된 실험군은 대조군들에 비해 대응행동 저하, 위궤양 발생, 체중감소가 심하게 나타났다. 신체·행동변화 및 위궤양의 스트레스반응에 대한 향정신성 약물의 단기 효과는 뚜렷하게 나타나지 않았다. 단지 chlorpromazine 투여군에서 위궤양을 완화시키는 경향성이 나타났다. 향정신성 약물의 장기효과로는 amitriptyline군의 위궤양 완화 효과가 뚜렷하였고, chlordiazepoxide군, chlorpromazine군에서도 위궤양 완화 경향성이 나타났다. 그리고 chlorpromazine군은 갈등조건에서 저하되는 지렛대누르기 대응행동을 회복시키는 경향성을 나타냈다.
Competence for natural transformation in <i>Neisseria gonorrhoeae</i>: components of DNA binding and uptake linked to type IV pilus expression (2002)

The mechanisms by which DNA is taken up into the bacterial cell during natural genetic transformation are poorly understood. Although related components essential to the uptake of DNA during transformation have been defined in Gram-negative species, it remains unclear whether DNA binding and uptake are dissociable events. Therefore, DNA uptake has been the earliest definable step in any Gram-negative transformation pathway. In the human pathogen Neisseria gonorrhoeae, sequence-specific DNA uptake requires an intact type IV pili (Tfp) biogenesis machinery along with three molecules that are dispensable for Tfp expression: ComP (a pilin subunit-like molecule), PilT (a cytoplasmic protein involved in pilus retraction) and ComE (a periplasmic protein with intrinsic DNA-binding activity). By conditionally altering the levels of ComP and PilT expression, we show here that DNA binding and uptake are resolvable events. Consequently, we are able to demonstrate that PilT is largely dispensable for functional DNA binding and, therefore, contributes specifically to uptake. Furthermore, sequence specificity in this system is imposed at the level of DNA binding, a process that is influenced by both ComP and PilE. However, sequence-specific DNA binding is not attributable to an intrinsic property of the Tfp subunit protein. Finally, we demonstrate the existence of a robust, non-specific DNA-binding activity associated with the expression of both Tfp and PilT, which is unrelated to transformation but obscures the observation of specific binding events.
Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity (2010)

Nonpeptidic chiral macrocycles were designed on the basis of an analogue of suberoylanilide hydroxamic acid (2) (SAHA, vorinostat) and evaluated against 11 histone deacetylase (HDAC) isoforms. The identification of critical amino acid residues highly conserved in the cap region of HDACs guided the design of the suberoyl-based macrocycles, which were expected to bear a maximum common substructure required to target the whole HDAC panel. A nanomolar HDAC inhibitory profile was observed for several compounds, which was comparable, if not superior, to that of 2. A promising cytotoxic activity was found for selected macrocycles against lung and colon cancer cell lines. Further elaboration of selected candidates led to compounds with an improved selectivity against HDAC6 over the other isozymes. Pair-fitting analysis was used to compare one of the best candidates with the natural tetrapeptide apicidin, in an effort to define a general pharmacophore that might be useful in the design of surrogates of peptidic macrocycles as potent and isoform-selective inhibitors.
FamClash: A method for ranking the activity of engineered enzymes (2004)

This article introduces the computational procedure FamClash for analyzing incompatibilities in engineered protein hybrids by using protein family sequence data. All pairs of residue positions in the sequence alignment that conserve the property triplet of charge, volume, and hydrophobicity are first identified, and significant deviations are denoted as residue-residue clashes. This approach moves beyond earlier efforts aimed at solely classifying hybrids as functional or nonfunctional by correlating the rank ordering of these hybrids based on their activity levels. Experimental testing of this approach was performed in parallel to assess the predictive ability of FamClash. As a model system, single-crossover ITCHY (incremental truncation for the creation of hybrid enzymes) libraries were prepared from the Escherichia coli and Bacillus subtilis dihydrofolate reductases, and the activities of functional hybrids were determined. Comparisons of the predicted clash map as a function of crossover position revealed good agreement with activity data, reproducing the observed V shape and matching the location of a local peak in activity.
Structure and Function of Glycosylated Tandem Repeats from Candida albicans Als Adhesins (2009)

Tandem repeat (TR) regions are common in yeast adhesins, but their structures are unknown, and their activities are poorly understood. TR regions in Candida albicans Als proteins are conserved glycosylated 36-residue sequences with cell-cell aggregation activity (J. M. Rauceo, R. De Armond, H. Otoo, P. C. Kahn, S. A. Klotz, N. K. Gaur, and P. N. Lipke, Eukaryot. Cell 5:1664-1673, 2006). Ab initio modeling with either Rosetta or LINUS generated consistent structures of three-stranded antiparallel beta-sheet domains, whereas randomly shuffled sequences with the same composition generated various structures with consistently higher energies. O- and N-glycosylation patterns showed that each TR domain had exposed hydrophobic surfaces surrounded by glycosylation sites. These structures are consistent with domain dimensions and stability measurements by atomic force microscopy (D. Alsteen, V. Dupres, S. A. Klotz, N. K. Gaur, P. N. Lipke, and Y. F. Dufrene, ACS Nano 3:1677-1682, 2009) and with circular dichroism determination of secondary structure and thermal stability. Functional assays showed that the hydrophobic surfaces of TR domains supported binding to polystyrene surfaces and other TR domains, leading to nonsaturable homophilic binding. The domain structures are like "classic" subunit interaction surfaces and can explain previously observed patterns of promiscuous interactions between TR domains in any Als proteins or between TR domains and surfaces of other proteins. Together, the modeling techniques and the supporting data lead to an approach that relates structure and function in many kinds of repeat domains in fungal adhesins.
Effect of Clonidine on Cigarette Cessation and in the Alleviation of Withdrawal Symptoms (1988)

Summary One hundred and eighteen cigarette smokers who wished to give up were randomly assigned to receive either clonidine (a=42), diazepam (n=38) or placebo (n=38) in a double‐blind trial. All subjects also received at least three sessions of behavioural treatment. End of treatment abstinence rates for clonidine, diazepam and placebo groups were 69%, 40% and 40% respectively (p<0.01). At later follow‐up, averaging 4.5 months from the end of treatment, abstinence rates were 57%, 37% and 37% respectively (NS). Compared with diazepam and placebo, clonidine received more positive ratings (p<0.005) and was more effective in relieving withdrawal symptoms (p<0.05). This report demonstrates that clonidine helps smokers to quit. The mechanism of action may involve decreased firing of α‐2‐noradrenergic cells in the locus coeruleus.
Oxidation of alkanes catalyzed by zeolite-encapsulated perfluorinated ruthenium phthalocyanines. (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of alkanes catalyzed by zeolite-encapsulated perfluorinated ruthenium phthalocyanines.Kenneth J. Balkus Jr., Mona Eissa, and Rosario LevadoCite this: J. Am. Chem. Soc. 1995, 117, 43, 10753–10754Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00148a022https://doi.org/10.1021/ja00148a022research-articleACS PublicationsRequest reuse permissionsArticle Views876Altmetric-Citations175LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Enhancement of two-photon-initiated coloration by energy transfer from dye to photochromic molecules in polymer films</title> (1999)

The method of increasing writing efficiency in 3D optical data storage system is proposed. This method is based on the energy transfer from material with high two photon absorption (TPA) to the photochromic molecules in thin polymer film. This method allows us to increase the writing efficiency of informative media more than one order of magnitude.
Implementation of multiple pagesize support in HP-UX (1998)

To reduce performance degradation from Translation Lookaside Buffer (TLB) misses without significant increase in TLB size, most modern processors implement TLBs that support multiple pagesizes. For example, Hewlett-Packard&apos;s PA-8000 processor allows 8 hardware pagesizes, in multiples of four, ranging from 4 Kbytes to 64 Mbytes. In implementing multiple pagesize support in HP-UX, wechose to create large pages at page-fault service time. Wehave a buddy system allocator that provides interfaces for allocating and freeing multiple pagesizes. We maintain the Virtual Memory (VM) data structures such as the pagetable entry, virtual page frame descriptor, and physical page frame descriptor based on the smallest pagesize, and represent a large pagesize as a collection of these base pagesize structures. In our implementation, VM operations on a large pagesize such as 16KB are carried out by looping over the 4KB-based constituent VM data structures. Our system offers significant application perfor...
A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples (2012)

CONTEXT Schizophrenia is a common, highly heritable, neurodevelopmental mental illness, characterized by genetic heterogeneity. OBJECTIVE To identify abnormalities in the transcriptome organization among older persons with schizophrenia and controls. DESIGN Weighted gene coexpression network analysis based on microarray transcriptomic profiling. SETTING Research hospital. PATIENTS Postmortem brain tissue samples from 4 different cerebrocortical regions (the dorsolateral prefrontal cortex, the middle temporal area, the temporopolar area, and the anterior cingulate cortex) from 21 persons with schizophrenia and 19 controls. MAIN OUTCOME MEASURES Results from gene expression microarray analysis, from analysis of coexpression networks, and from module eigengene, module preservation, and enrichment analysis of schizophrenia-related genetic variants. RESULTS The oligodendrocyte, microglial, mitochondrial, and neuronal (GABAergic and glutamatergic) modules were associated with disease status. Enrichment analysis of genome-wide association studies in schizophrenia and other illnesses demonstrated that the neuronal (GABAergic and glutamatergic) and oligodendrocyte modules are enriched for genetically associated variants, whereas the microglial and mitochondrial modules are not, providing independent support for more direct involvement of these gene expression networks in schizophrenia. Interregional coexpression network analysis showed that the gene expression patterns that typically differentiate the frontal, temporal, and cingulate cortices in controls diminish significantly in persons with schizophrenia. CONCLUSIONS These results support the existence of convergent molecular abnormalities in schizophrenia, providing a molecular neuropathological basis for the disease.