gebhart/patrepeval huggingface dataset:
Paraoxonase (Pon1) gene in mice: sequencing, chromosomal localization and developmental expression (1997)

Serum paraoxonase hydrolyses the toxic metabolites of several organophosphorus insecticides, as well as the nerve agents soman and sarin. We have previously shown that elevated serum paraoxonase levels protect mice against organophosphate toxicity. In the present study, we determined the cDNA sequence and chromosomal location of the mouse paraoxonase gene, as well as its developmental expression in mice and rats. The mouse cDNA encodes a protein of 355 amino acids and shows 81% identity with the human sequence. In situ hybridization demonstrated that the mouse paraoxonase gene maps to chromosome 6, a region conserved with the paraoxonase region of chromosome 7q21-22 in humans. Serum paraoxonase activities toward three substrates, paraoxon, chlorpyrifos-oxon and diazoxon, were very low at birth and increased with age reaching adult levels at 20 days in mice and 25 days in rats. The increase of serum paraoxonase activity in developing animals correlates well with the increased resistance to organophosphate poisoning that has been reported in previous studies.
Distributed data management in workflow environments (2002)

Most existing workflow management systems (WFMSs) are based on a client/server architecture. This architecture simplifies the overall design but it does not match the distributed nature of workflow applications and imposes severe limitations in terms of scalability and reliability. Moreover workflow engines are not very sophisticated in terms of data management. Forgetting the fact that workflow is, to a great extent, data flow. In this paper we propose a novel architecture to address the issue of data management in a WFMS. This architecture is based on a fully distributed workflow engine for control flow, plus a set of loosely synchronized replicated databases for dataflow. The resulting system offers greater robustness and reliability as well as much better data handling capabilities than existing approaches. To better illustrate this novel architecture and its implications, two commercial systems are employed in this paper: FlowMark, as the workflow engine, and the replication capabilities of Lotus Notes, as the support system for distributed data management.
A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes (2018)

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control differentiation of the two sexes. The female transcript, unlike the male, contains an exon (exon 5) whose sequence is highly conserved in all Anopheles mosquitoes so far analyzed. We found that CRISPR-Cas9-targeted disruption of the intron 4-exon 5 boundary aimed at blocking the formation of functional AgdsxF did not affect male development or fertility, whereas females homozygous for the disrupted allele showed an intersex phenotype and complete sterility. A CRISPR-Cas9 gene drive construct targeting this same sequence spread rapidly in caged mosquitoes, reaching 100% prevalence within 7-11 generations while progressively reducing egg production to the point of total population collapse. Owing to functional constraint of the target sequence, no selection of alleles resistant to the gene drive occurred in these laboratory experiments. Cas9-resistant variants arose in each generation at the target site but did not block the spread of the drive.
Application of traction drives as servo mechanisms (1985)

The suitability of traction drives for a wide class of aerospace control mechanisms is examined. Potential applications include antenna or solar array drive positioners, robotic joints, control moment gyro (CMG) actuators and propeller pitch change mechanisms. In these and similar applications the zero backlash, high torsional stiffness, low hysteresis and torque ripple characteristics of traction drives are of particular interest, as is the ability to run without liquid lubrication in certain cases. Wear and fatigue considerations for wet and dry operation are examined along with the tribological performance of several promising self lubricating polymers for traction contracts. The speed regulation capabilities of variable ratio traction drives are reviewed. A torsional stiffness analysis described suggests that traction contacts are relatively stiff compared to gears and are significantly stiffer than the other structural elements in the prototype CMG traction drive analyzed. Discussion is also given of an advanced turboprop propeller pitch change mechanism that incorporates a traction drive.
Amplitude- and rise-time-compensated filters (2023)

An amplitude-compensated rise-time-compensated filter for a pulse time-of-occurrence (TOOC) measurement system is disclosed. The filter converts an input pulse, having the characteristics of random amplitudes and random, non-zero rise times, to a bipolar output pulse wherein the output pulse has a zero-crossing time that is independent of the rise time and amplitude of the input pulse. The filter differentiates the input pulse, along the linear leading edge of the input pulse, and subtracts therefrom a pulse fractionally proportional to the input pulse. The filter of the present invention can use discrete circuit components and avoids the use of delay lines.
Characteristics of leather tanned with nano-SiO2 (2005)

A nano-precusor which can, in-situ, produce nano-SiO 2 under particular triggering condition was introduced into leather to improve the hydrothermal stability. In order to elucidate the reaction of nano-SiO 2 with proteinand how it influences the properties of the protein, collagen was used as a model in a detailed investigation. The results from FTIR (Infrared) indicated that two new chemical bonds arose during the formation of the organic-inorganic nano-hybrid. One appears to be the reaction between nano-SiO 2 formed in-situ by the hydrolysis of tetraethoxy silane and the -C=N-groups of arginine, histidine, and tryptophane in the backbone of collagen. In a second bond, occurring at the same time as the condensation of silanol proceeds, the pendent hydroxyl groups of collagen may partly react with Si-OH and form a strong interaction between the organic and inorganic phases. These two chemical bonds seem to contribute to the leather's high hydrothermal stability. The size distribution of nano-SiO 2 as determined by Atomic Force Microscopy is approximately 50-80 nm and there appeared to be no agglomeration. Organic-inorganic nano-hybrid can improve the hydrolysis stability of collagen efficiently in the presence of enzyme, acid, and alkali. When the bated pelt is treated with 0.3 wt % nano-SiO 2 (based on bated pelt weight), the shrinkage temperature reached above 95°C. Although the mechanical properties of nano-SiO 2 tanned leather are inferior to chromium tanned leather, other properties of nano-SiO 2 tanned leather, such as yield, grain, fullness and softness together with washability are all superior to chromium tanned leather.
Development of a Hot-Water Immersion Quarantine Treatment for Hawaiian-Grown ‘Brazilian’ Bananas1 (1982)

A 15-min, 50°C hot-water immersion treatment was developed as an alternative quarantine treatment to ethylene dibromide fumigation for ‘Brazilian’ variety bananas against the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), the melon fly, Dacus cucurbitae Coquillett, and the oriental fruit fly, D. dorsalis Hendel. The hot-water immersion disinfested ‘Brazilian’ variety bananas without detriment to either fruit quality or shelf life.
Online support functions of prescription order system and prescription audit in an integrated hospital information system (1988)

The role of the online prescription support functions of a prescription order entry system was analysed and the results of the prescription audit by pharmacists were examined. In the Kochi Medical School Hospital, an online prescription order system has been developed as part of an integrated hospital information system named IMIS (the Integrated Medical Information System), in which all the physicians enter their prescription orders into online display terminals. The prescription order entry system is provided with prescription support functions, which check the entered prescription data, issue warnings, and offer information about drugs or patients. The prescription order system reduces the incidence of simple prescription mistakes and greatly decreases the cases of inquiries by pharmacists. However, results of the analysis show that such functions as warnings of double order and repeated prescription of a drug do not work as well as expected. The system would thus require some kind of intelligence like that of the auditing pharmacists or that of the physicians with accurate knowledge of clinical pharmacology.
Signal transduction and nuclear targeting: regulation of transcription factor activity by subcellular localisation (1993)

ABSTRACT Over the last few years a number of international meetings have boasted titles along the lines of “from receptor to nucleus” reflecting a desire to construct a pathway linking the endpoints of different regulatory events. However, for historical and technical reasons, research effort has been focused overwhelmingly on receptor/ligand or transcription factor/DNA interactions. The task confronting biologists now is to link up these two extremes. Our present under-standing of these intermediary processes is in many cases rudimentary, but it is clear that signal transduction from membrane to nucleus often involves many steps, and it also appears that several pathways can use common intermediates, which raises interesting questions in speed and specificity.
Dual TCR T Cells: Identity Crisis or Multitaskers? (2019)

Dual TCR T cells are a common and natural product of TCR gene rearrangement and thymocyte development. As much as one third of the T cell population may have the capability to express two different TCR specificities on the cell surface. This discovery provoked a reconsideration of the classic model of thymic selection. Many potential roles for dual TCR T cells have since been hypothesized, including posing an autoimmune hazard, dominating alloreactive T cell responses, inducing allergy, and expanding the TCR repertoire to improve protective immunity. Yet, since the initial wave of publications following the discovery of dual TCR T cells, research in the area has slowed. In this study, we aim to provide a brief but comprehensive history of dual TCR T cell research, re-evaluate past observations in the context of current knowledge of the immune system, and identify key issues for future study.
특집 논문 (特輯 論文) : `11 춘계학술대회 우수 논문 ; 수용성 폴리아닐린/탄소나노튜브 복합재료의 제조 및 물성분석 (2011)

본 연구에서는 탄소나노튜브를 물상에서 균일하게 분산시키기 위하여 물에 녹으면서 분자 내에서 자체 도핑이 가능한 새로운 종류의 그래프트 공중합체(PSSA-g-PANI, poly(styrenesulfonic acid-graft-aniline))를 합성하였고, 그 분산 능력을 실험해 보았다. PANI 고분자는 벤조이드와 퀴노이드 구조가 반복되어 존재하는 판상구조로 탄소나노튜브와 같은 탄소나노 소재의 벽에 강하게 결합할 수 있고, 따라서 짧은 시간의 sonication 처리 만으로 나노튜브를 분산시킬 수 있었고 그 분산 용액의 장시간 안정성은 다른 상용화된 분산제보다 뛰어났다. 또한 PSSA-g-PANI 그래프트 고분자/탄소나노튜브 복합 필름은 대략 1.5-2.5 S/cm의 전도도를 기록하였다.
Fertility in cows after treatment with a prostaglandin analogue with or without progesterone (1976)

Two infections each of 500 mug Cloprostenol (ICI-80,996), a synthetic analogue of PGF-2alpha, 11 or 12 days apart or pretreatment for 7 days with progesterone from an intravaginal silastic coil and one injection of 500 mug Cloprostenol were both effective in synchronizing oestrus in heifers or nursing beef cows. After two inseminations at 72 and 96 hr after the end of treatment, the calving rate for cows observed in oestrus after both treatments or for cows that had oestrous-like mucus after the progesterone+Cloprostenol treatment did not differ from that of control cows, but was significantly (P less than 0-025) lower for cows diagnosed as ready for insemination by the characteristics of mucus after the two injections of Cloprostenol. Treated cows disgnosed per rectum as having inactive ovaries had a significantly (P less than 0-005) lower calving rate than those diagnosed as having active ovaries at the start of treatment. Significantly (P less than 0-005) more treated than control cows were inseminated and became pregnant in the first 15 days of the treatment period, but the overall level of reproductive efficiency was low.
Identification of MicroRNAs Regulating Reprogramming Factor LIN28 in Embryonic Stem Cells and Cancer Cells (2010)

LIN28 (a homologue of the Caenorhabditis elegans lin-28 gene) is an evolutionarily conserved RNA-binding protein and a master regulator controlling the pluripotency of embryonic stem cells. Together with OCT4, SOX2, and NANOG, LIN28 can reprogram somatic cells, producing induced pluripotent stem cells. Expression of LIN28 is highly restricted to embryonic stem cells and developing tissues. In human tumors, LIN28 is up-regulated and functions as an oncogene promoting malignant transformation and tumor progression. However, the mechanisms of transcriptional and post-transcriptional regulation of LIN28 are still largely unknown. To examine microRNAs (miRNAs) that repress LIN28 expression, a combined in silico prediction and miRNA library screening approach was used in the present study. Four miRNAs directly regulating LIN28 (let-7, mir-125, mir-9, and mir-30) were initially identified by this approach and further validated by quantitative RT-PCR, Western blot analysis, and a LIN28 3'-UTR reporter assay. We found that expression levels of these four miRNAs were clustered together and inversely correlated with LIN28 expression during embryonic stem cell differentiation. In addition, the expression of these miRNAs was remarkably lower in LIN28-positive tumor cells compared with LIN28-negative tumor cells. Importantly, we demonstrated that these miRNAs were able to regulate the expression and activity of let-7, mediated by LIN28. Taken together, our studies demonstrate that miRNAs let-7, mir-125, mir-9, and mir-30 directly repress LIN28 expression in embryonic stem and cancer cells. Global down-regulation of these miRNAs may be one of the mechanisms of LIN28 reactivation in human cancers.
Underground gas storage: estimating gas column height and saturation with time lapse seismic (2001)

Seismic monitoring is often used to check hydrocarbon movements during production. On the site of Céré-la-Ronde, an underground water-bearing gas storage facility developed by Gaz de France, a methodology has been implemented for estimating gas column height and saturation with time lapse seismic. The methodology is based on the Gassmann model, on the measurement of time-shifts and on the computation of a specific seismic function. The time-shifts obtained by cross-correlation techniques are used to derive the residual time-shift Δ t induced by the presence of gas within the reservoir. A specific function is used to estimate both the gas bubble extension and the gas time thickness H t . It is shown that knowledge of H t and Δ t and the use of a Gassmann model can lead to an estimation of the gas saturation. The methodology has been applied successfully on conventional seismic profiles as well as on vertical seismic profiles (VSP). The results obtained with seismic data are in good agreement with those obtained by logging (sonic and neutron logs) but with a lateral investigation, which is much larger than the one given by logging techniques. In our field example, the gas anomaly has been checked over a distance of 300 m with VSP data and over 2 km with surface seismic data.
Enteroaggregative Escherichia coli (1998)

Enteroaggregative Escherichia coli (EAggEC) are a group of E. coli characterized by the ability to adhere to cultured cell monolayers with an aggregative or 'stacked brick' adhesion phenotype. These strains of E. coli are distinct from other pathogenic groups of E. coli. Epidemiological evidence suggests that strains of EAggEC are a significant cause of protracted diarrhoea in children, and may cause diarrhoea in adults. The group is heterogeneous, comprising a diverse range of serotypes that possess a variety of putative virulence factors. These include an enterotoxin similar to the heat-stable enterotoxin of enterotoxigenic E. coli, putative haemolysins and toxins, and various types of fimbriae and outer membrane proteins that may be involved in the adhesion process. The role of these factors in the production of disease is unclear. Diagnosis of EAggEC infection is problematic; serotyping alone cannot identify strains of E. coli expressing an EAggEC phenotype. Currently, EAggEC are identified by either cell adhesion tests or DNA-based tests involving gene probes or polymerase chain reaction (PCR) for detecting the genes encoding cell adhesion. The nature and significance of strains of E. coli expressing an EAggEC phenotype are poorly understood. This article reviews the current literature and speculates on the direction of future studies to define this emerging group of bacteria.
Optimal Predictive Code Offloading (2014)

Modern mobile devices like smart phones and tablets are equipped with powerful processing and memory resources, enabling resource-intensive mobile applications such as high-end mobile games. The main limitation, however, remains the energy resource. To improve the energy efficiency, code offloading
Effect of electromagnetic stimulation with different waveforms on cultured chick tendon fibroblasts (1994)

An energy efficient electromagnetic stimulator device for fracture healing was compared to a commercially available device in stimulating cell growth in tissue cultures. The energy efficient device, which conserves energy by using a bidirectional time-dependent magnetic wave form, and the commercially available stimulator, which uses a unidirectional time-dependent magnetic wave form, were tested on chick tendon fibroblasts in primary culture. Comparing non-stimulated control and cells electromagnetically stimulated with unidirectional and bidirectional waveforms showed that at the growth phase between days 2 and 3, both electrical stimulation techniques increased cell division as measured by DNA synthesis. When cells were dividing rapidly, collagen synthesis was reduced. When the cells reached the confluence there was no difference among the groups (control, unidirectionally stimulated, and bidirectionally stimulated) in terms of number of cells or collagen produced.
Time-frequency analysis of the electrogastrogram: evaluation of STFT, adaptive spectral analysis and exponential distribution (2002)

The aim of this paper is to compare the performance of the short-time Fourier transform (STFT), adaptive spectral analysis and exponential distribution (ED) methods in estimating the changes of both amplitude and frequency of the gastric slow wave with time, and detecting gastric dysrhythmic events from the electrogastrogram (EGG). Results from both computer simulations and real applications show that the adaptive spectral analysis method is more accurate in the detection of gastric dysrhythmia with brief duration, whereas STFT method is more appropriate for the estimation of signal amplitude. The performance of the ED method appears to be in between the STFT method and adaptive spectral analysis method.
RRSGAN: Reference-Based Super-Resolution for Remote Sensing Image (2021)

Remote sensing image super-resolution (SR) plays an important role by supplementing the lack of original high-resolution (HR) images in the study scenarios of large spatial areas or long time series. However, due to the lack of imagery information in low-resolution (LR) images, single-image super-resolution (SISR) is an inherently ill-posed problem. Especially, it is difficult to reconstruct the fine textures of HR images at large upscaling factors (e.g., four times). In this work, based on Google Earth HR images, we explore the potential of the reference-based super-resolution (RefSR) method on remote sensing images, utilizing rich texture information from HR reference (Ref) images to reconstruct the details in LR images. This method can use existing HR images to help reconstruct the LR images of long time series or a specific time. We build a reference-based remote sensing SR data set (RRSSRD). Furthermore, by adopting the generative adversarial network (GAN), we propose a novel end-to-end reference-based remote sensing GAN (RRSGAN) for SR. RRSGAN can extract the Ref features and align them to the LR features. Eventually, the texture information in the Ref features can be transferred to the reconstructed HR images. In contrast to the existing RefSR methods, we propose a gradient-assisted feature alignment method that adopts the deformable convolutions to align the Ref and LR features and a relevance attention module (RAM) to improve the robustness of the model in different scenarios (e.g., land cover changes and cloud coverage). The experimental results demonstrate that RRSGAN is robust and outperforms the state-of-the-art SISR and RefSR methods in both quantitative evaluation and visual results, which indicates the great potential of the RefSR method for remote sensing tasks. Our code and data are available at <uri xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">https://github.com/dongrunmin/RRSGAN</uri> .
Manipulating Steady Heat Conduction by Sensu-shaped Thermal Metamaterials (2015)

The ability to design the control of heat flow has innumerable benefits in the design of electronic systems such as thermoelectric energy harvesters, solid-state lighting, and thermal imagers, where the thermal design plays a key role in performance and device reliability. In this work, we employ one identical sensu-unit with facile natural composition to experimentally realize a new class of thermal metamaterials for controlling thermal conduction (e.g., thermal concentrator, focusing/resolving, uniform heating), only resorting to positioning and locating the same unit element of sensu-shape structure. The thermal metamaterial unit and the proper arrangement of multiple identical units are capable of transferring, redistributing and managing thermal energy in a versatile fashion. It is also shown that our sensu-shape unit elements can be used in manipulating dc currents without any change in the layout for the thermal counterpart. These could markedly enhance the capabilities in thermal sensing, thermal imaging, thermal-energy storage, thermal packaging, thermal therapy, and more domains beyond.