gebhart/patrepeval huggingface dataset:
BLV-CoCoMo-qPCR: a useful tool for evaluating bovine leukemia virus infection status (2012)

Our results suggest that the quantitative measurement of proviral load by BLV-CoCoMo-qPCR is useful tool for evaluating the progression of BLV-induced disease. BLV-CoCoMo-qPCR allows us to monitor the spread of BLV infection in different viewpoint compared with classical serotest.
A Highly Isolated Dual-polarized Crossed Dipole Array Antenna for Multi-mission Applications (2018)

A crossed dipole antenna array with dual linear polarization capability is designed and fabricated. Practical techniques such as utilizing stripline structures for baluns contribute to high isolation between the two polarizations. A better than 50 dB broadside port isolation is achieved over the entire frequency range of 2.7-3 GHz. Additionally, the isolation remains below 40 dB in scanning up to ±45° in the principal planes. A very low cross-polarization level over -60 dB is achieved owing to an image configuration of elements in the array arrangement. These features along with matched copolar beams, simple structure, and ease of fabrication make the proposed antenna array an ideal candidate for multi-mission applications.
Multi-port Power Electric Interface for Renewable Energy Sources (2009)

In order to accommodate increasing energy demand from "more electrified" domestic and vehicular applications, simultaneous use of various renewable sources are encouraged. Multiple converters are commonly adopted to process the renewable power as a distributed power system (DPS). However, due to the loose structure of DPS, reliability and load/source regulation will degrade as compared to an integrated converter system. This paper presents the concept of Multi-port Power Electronic Interface (MPEI) for renewable energy sources. With a unified converter topology and highly integrated digital control system, MPEI possesses the inherent capability of both source disturbance rejection and load dynamics regulation. MPEI identification, modeling and design are treated in a systematic manner in this paper. Power stages and digital control system will be implemented for a five-port MPEI in this paper. Experimental results will be presented to prove the feasibility of system design methodology.
Call Admission Control and Load Balancing for Voice Over Ip (2002)

IP networks are traditionally designed to support a best-effort service, with no guarantees on the reliable and timely delivery of packets. With the migration of real-time applications such as voice onto IP-based platforms, the existing IP network capabilities become inadequate to provide the quality-of-service (QoS) levels that the end-users are accustomed to. While new protocols such as DiffServ and MPLS allow some amount of traffic prioritization, guaranteed QoS requires call admission control. This paper reviews several possible implementations and shows simulation results for one promising method that makes efficient use of the network and is scalable to large networks.
Novel technique to measure mutual bulk fluid diffusion using NMR 1-D gradient (2020)

Many modelling and theoretical studies have shown that diffusion can be a significant transport mechanism in low-permeability porous media. Understanding the process allows engineers to better predict reservoir performance during both primary production and enhanced recovery in unconventional reservoirs. Direct measurement of effective diffusion in tight rocks is difficult, due to small pore volumes and the lack of techniques to actually monitor the process. Conventional diffusion measurements generally require fluid sampling, which induces a pressure transient which changes the mass transfer mechanism. Previously, we introduced a novel technique to measure tortuosity in nano-porous media by simultaneously monitoring methane versus nitrogen concentrations at high pressure using transmission Infrared Spectroscopy (IR). To complete the estimation of effective diffusion, bulk fluid diffusion coefficient also needs to be measured. In this study, we demonstrate the usage of Nuclear Magnetic Resonance (NMR) 1-D imaging to examine the dynamic change of Hydrogen Index (HI) across the interface between two bulk fluids. The experiment was conducted between a crude oil sample and methane; fluid samples were pressurized within an NMR transparent ZrO 2 pressure cell which operates at pressures up to 10,000 psi. The Hydrogen Index (HI) profile was continuously measured and recorded for 7 days. The results provided oil the swelling factor and the concentration profile as a function of both time and distance. These data then were fitted with Maxwell-Stefan equation to precisely back calculate the diffusion coefficient between oil and gas samples at high pressure. Accurate estimation of tortuosity and fluid diffusion is critical for the gas injection strategy in a shale formation. Greater tortuosity and smaller fluid diffusion rate lead to longer injection and production times for desirable economic recovery.
Discovery of (<i>R</i>)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode (2017)

On the basis of Ibrutinib's core pharmacophore, which was moderately active to EGFR T790M mutant, we discovered novel epidermal growth factor receptor (EGFR) inhibitor compound 19 (CHMFL-EGFR-202), which potently inhibited EGFR primary mutants (L858R, del19) and drug-resistant mutant L858R/T790M. Compound 19 displayed a good selectivity profile among 468 kinases/mutants tested in the KINOMEscan assay (S score (1) = 0.02). In particular, it did not exhibit apparent activities against INSR and IGF1R kinases. The X-ray crystal structure revealed that this class of inhibitors formed a covalent bond with Cys797 in a distinct "DFG-in-C-helix-out" inactive EGFR conformation. Compound 19 displayed strong antiproliferative effects against EGFR mutant-driven nonsmall cell lung cancer (NSCLC) cell lines such as H1975, PC9, HCC827, and H3255 but not the wild-type EGFR expressing cells. In the H1975 and PC9 cell-inoculated xenograft mouse models, compound 19 exhibited dose-dependent tumor growth suppression efficacy without obvious toxicity. Compound 19 might be a potential drug candidate for EGFR mutant-driven NSCLC.
Generation of highly porous Li‒Mg and Li‒Zn alloys from kinetically controlled lithiation (2001)

Abstract Li‒Mg and Li‒Zn alloy electrodes are prepared by the kinetically controlled vapour deposition (KCVD) of Li‒Mg and Li‒Zn alloys on a temperature-controlled substrate. The mode of preparation greatly influences the microstructure, surface morphology and electrochemical properties of these Li‒Mg and Li‒Zn alloys. The KCVD technique, as applied to the generation of Li-Mg alloys, establishes the composition of each prepared alloy by independently varying the temperature of the molten lithium, the temperature of a solid magnesium surface with which the lithium interacts, and the temperature of the substrate on which a resulting intimately mixed Li-Mg mixture is deposited. Here, the required temperature for lithium induced magnesium vaporization is more than 200°C below the magnesium melting point. The effect of variable temperature control on the microstructure, morphology and electrochemical properties of the vapour-deposited alloys has been studied and the diffusion coefficients for lithium in the Li‒Mg alloy electrodes prepared by the KCVD method are found to be in the range 1.2–5.2 × 10−7 cm2/s−1 at room temperature. The diffusion coefficients for moderate lithium content alloys, firstly, exceed those for standard alloy preparation and, secondly, are two to three orders of magnitude larger than those for other lithium alloy systems (e.g. 6.0 × 10−10cm2 s−1 in LiA1). A variant of the KCVD technique is used to generate highly porous Li‒Zn alloy films prepared by controlling the temperature of a molten lithium source and the rate at which a zinc source, placed in proximity to the lithium, equilibrates in temperature as the lithium interacts with the zinc. Diffusion coefficients for the Li‒Zn alloy electrodes prepared by this variant of the KCVD method vary from 10−7 to 10−9 cm2 s−1 at room temperature, depending on the alloy composition. This should be compared with the standard alloy whose diffusion coefficient never exceeds 109 cm2 s−1 for any composition. These observations suggest that alloys generated using kinetically controlled lithiation display an enhanced porosity and diffusivity useful for a number of applications.
Supplemental Figure 6 from Tumor Radiosensitization by Monomethyl Auristatin E: Mechanism of Action and Targeted Delivery (2023)

<p>Combination of increased delivery of ACPP-cRGD-MMAE with IR significantly improved tumor regression.</p>
The effects of <scp>RecO</scp> deficiency in <i>Lactococcus lactis</i><scp>NZ9000</scp> on resistance to multiple environmental stresses (2014)

Results indicate that RecO has positively improved the survival of L. lactis NZ9000, protected its key enzymes and enhanced its fermentation efficiencies. Our research confirms the role of RecO in enhancing tolerances to multiple stresses of L. lactis NZ9000, and puts forward the suggestion that RecO could be used in other industrial microorganisms as a new anti-stress component to improve their resistance to various stresses.
Active index model: a unique approach for regional quantitative morphometry in longitudinal and cross-sectional studies (2007)

Recent advancements in digital medical imaging have opened avenues for quantitative analyses of different volumetric and morphometric indices in response to a disease or a treatment. However, a major challenge in performing such an analysis is the lack of a technology of building <i>a mean anatomic space (MAS)</i> that allows mapping data of a given subject onto MAS. This approach leads to a tool for point-by-point regional analysis and comparison of quantitative indices for data coming from a longitudinal or transverse study. Toward this goal, we develop a new computation technique, called <i>Active Index Model (AIM)</i>, which is a unique tool to solve the stated problem. AIM consists of three building blocks - (1) development of MAS for a particular anatomic site, (2) mapping a specific data onto MAS, (3) regional statistical analysis of data from different populations assessing regional response to a disease or treatment progression. The AIM presented here is built at the training phase from two known populations (e.g., normal and diseased) which will be immediately ready for diagnostic purpose in a subject whose clinical status is unknown. AIM will be useful for both cross sectional and longitudinal studies and for early diagnostic. This technique will be a vital tool for understanding regional response of a disease or treatment at various stages of its progression. This method has been applied for analyzing regional trabecular bone structural distribution in rabbit femur via micro-CT imaging and to localize the affected myocardial regions from cardiac MR data.
Interference Mitigation through Successive Cancellation in Heterogeneous Networks (2013)

We present a practical interference management scheme for heterogeneous networks (HetNets). The underlying ideas are based on (i) Han-Kobayashi-type message splitting (MS) where the receivers decode and cancel “part” of the interference which is accordingly optimized by the transmitters to ensure decoding and (ii) opportunistic interference cancellation (OIC) where the interfering transmitters act independently of the receivers that employ interference cancellation. We develop a novel transmission and reception scheme, called joint MS and OIC (MS-OIC), that engages both MS and OIC to account for a practical HetNet system with multiple macrocells and femtocells. The MS component includes a precoder design that judiciously maximizes the weighted sum throughput via the enabling of interference cancellation. A system design along with a novel scheduler that facilitates MS-OIC in a general HetNet system is also developed. System level simulations for a general HetNet system are presented, and the proposed MS-OIC scheme is compared with benchmark schemes such as Coordinated Beamforming (CBF) and joint CBF and Almost Blank Subframes (CBF-ABS). It is observed that the proposed MS-OIC scheme improves the macrocell throughput substantially, balances the achievable rates between the macrocell and femtocell users, and provides significant outage performance improvement in the system.
Energy management service layer for cloud computing costs reduction (2016)

Reducing the energy-related costs is a significant concern for Cloud Computing providers. Although many efficiency techniques had been evaluated, incentives for demand management according to energy sector information is not usual. The energy prices and availability vary according to daytime and geographical position, which implies in different prices for the resources in distinct periods. The higher flexibility of the Cloud Computing capacity regarding energy provider enables the adaptation of the infrastructure to take advantage of the energy prices fluctuation and the different sources availability. This work defines an infrastructure layer that allows negotiation and management of computing resources based on energy information for various time intervals. The proposed solution sets processing plans and establishes scheduling conditions to seize the most efficient usage of energy. A model that translates the customer contract information, searches for the lowest energy prices, and allocates the services based on these searches, is presented to reinforce our approach. Our results point out financial savings of almost 20% in comparison to non-energy management techniques.
Enhancing ATM Network Performance by Optimizing the Virtual Network Configuration (1996)

Virtual or logical subnetworks are expected to play an important role in large B-ISDN configurations. This gives an additional degree of freedom to ATM network architectures, since even for a fixed physical network the logical configuration can still vary depending on particular demands and conditions. This new degree of freedom calls for new solutions to utilize the opportunity for the potential enhancement of network performance by optimizing the logical configuration, as part of optimizing the distributed network architecture. In this paper a framework and model, along with efficient solution algorithms, are presented to dimension virtual ATM networks on top of the same physical infrastructure network, such that the virtual networks share the infrastructure, while the total network revenue is optimized. The algorithms are tried on various network scenarios and a trade-off between the quality of the result and running time is exhibited.
Diffractive superresolution elements (1997)

Superresolution phase-only pupil filters designed to utilize the degrees of freedom made available by diffractive optics technology are investigated theoretically. These so-called diffractive superresolution elements improve the quality of the superresolved diffraction pattern from the point of view of Strehl ratio, reduction of the spot size, control of the sidelobe effects, optimization procedures, and fabrication tolerances. The performance of these elements is studied, and the nature of the solutions obtainable with binary and multiple-phase structures is analyzed. Design considerations and solutions for applications such as confocal scanning microscopy and optical data storage are presented. Optimization of the degrees of freedom to satisfy desired constraints is discussed and compared with other methods.
Pyrin-Only Protein 2 Modulates NF-κB and Disrupts ASC:CLR Interactions (2007)

NF-kappaB is pivotal for transactivation of cell-cycle regulatory, cytokine, and adhesion molecule genes and is dysregulated in many cancers, neurodegenerative disorders, and inflammatory diseases. Proteins with pyrin and/or caspase recruitment domains have roles in apoptosis, innate immunity, and inflammation. Many pyrin domain (PYD) proteins modulate NF-kappaB activity as well as participate in assembling both the perinuclear "apoptotic speck" and the pro-IL1beta/IL-18-converting inflammasome complex. "Pyrin-only" proteins (POP) are attractive as negative regulators of PYD-mediated functions and one such protein, POP1, has been reported. We report the identification and initial characterization of a second POP. POP2 is a 294 nt single exon gene located on human chromosome 3 encoding a 97-aa protein with sequence and predicted structural similarity to other PYDs. Highly similar to PYDs in CATERPILLER (CLR, NLR, NALP) family proteins, POP2 is less like the prototypic pyrin and ASC PYDs. POP2 is expressed principally in peripheral blood leukocytes and displays both cytoplasmic and nuclear expression patterns in transfected cells. TNF-alpha-stimulated and p65 (RelA)-induced NF-kappaB-dependent gene transcription is inhibited by POP2 in vitro by a mechanism involving changes in NF-kappaB nuclear import or distribution. While colocalizing with ASC in perinuclear specks, POP2 also inhibits the formation of specks by the CLR protein CIAS1/NALP3. Together, these observations demonstrate that POP2 is a negative regulator of NF-kappaB activity that may influence the assembly of PYD-dependent complexes.
The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside (2014)

Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This review summarises current evidence regarding the role of NO in the regulation of cerebral blood flow at rest, under physiological conditions, and after brain injury, focusing on subarachnoid haemorrhage, traumatic brain injury, and ischaemic stroke and following cardiac arrest. We also review the role of NO in the response to hypoxic insult in the developing brain. NO depletion in ischaemic brain tissue plays a pivotal role in the development of subsequent morbidity and mortality through microcirculatory disturbance and disordered blood flow regulation. NO derived from endothelial nitric oxide synthase (eNOS) appears to have neuroprotective properties. However NO derived from inducible nitric oxide synthase (iNOS) may have neurotoxic effects. Cerebral NO donor agents, for example sodium nitrite, appear to replicate the effects of eNOS derived NO, and therefore have neuroprotective properties. This is true in both the adult and immature brain. We conclude that these agents should be further investigated as targeted pharmacotherapy to protect against secondary brain injury.
Feedback control for adaptive live video streaming (2011)

Multimedia content feeds an ever increasing fraction of the Internet traffic. Video streaming is one of the most important applications driving this trend. Adaptive video streaming is a relevant advancement with respect to classic progressive download streaming such as the one employed by YouTube. It consists in dynamically adapting the content bitrate in order to provide the maximum Quality of Experience, given the current available bandwidth, while ensuring a continuous reproduction. In this paper we propose a Quality Adaptation Controller (QAC) for live adaptive video streaming designed by employing feedback control theory. An experimental comparison with Akamai adaptive video streaming has been carried out. We have found the following main results: 1) QAC is able to throttle the video quality to match the available bandwidth with a transient of less than 30s while ensuring a continuous video reproduction; 2) QAC fairly shares the available bandwidth both in the cases of a concurrent TCP greedy connection or a concurrent video streaming flow; 3) Akamai underutilizes the available bandwidth due to the conservativeness of its heuristic algorithm; moreover, when abrupt available bandwidth reductions occur, the video reproduction is affected by interruptions.
Kinetics of "P"-site-mediated inhibition of adenylyl cyclase and the requirements for substrate. (1990)

The kinetics of "P"-site-mediated inhibition of adenylyl cyclase was studied with the detergent-solubilized enzyme from rat brain. Mn2(+)-activated adenylyl cyclase exhibited typical noncompetitive inhibition by 2'-d3'-AMP or 2',5'-dideoxyadenosine (2',5'-ddAdo). However, enzyme that was preactivated with guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) or proteolytically with ninhibin (+ GTP gamma S) exhibited apparently uncompetitive inhibition with either 2'-d3'-AMP or 2',5'-ddAdo and with either MgATP or MgApp(NH)p (adenosine 5'-(beta gamma-imino)triphosphate) as substrate. Inhibition increased with increasing substrate concentration, consistent with distinct domains for catalysis and the P-site and the formation of a 2'-d3'-AMP.C.MgATP complex. This conclusion was supported by the kinetics of product inhibition. For both cAMP and inorganic pyrophosphate (MgPPi) inhibition was mixed, suggesting that product release is likely random sequential. Although MgPPi enhanced inhibition in the presence of P-site agonist, it did not affect the dissociation constant for P-site agonist. The uncompetitive character of P-site-mediated inhibition and the independence of inhibition by MgPPi and P-site agonist imply that the P-site binding domain is distinct from the substrate binding domain. Given the structural requirements for catalysis and for P-site-mediated inhibition, these domains would be expected to be homologous. Sensitivity to P-site-mediated inhibition was also dependent on the structure of ATP, with the following IC50 values for 2'-d3'-AMP: ATP approximately 2'-dATP (approximately 1 microM); adenosine 5'-O-(3-thiotriphosphate) (approximately 5 microM); App(NH)p (approximately 30 microM); adenosine 5'-(beta gamma-methylene)triphosphate (approximately 300 microM). The differing effectiveness of the ATP analogs to support P-site inhibition was not due to their binding at the P-site. This effect of substrate was also observed with the platelet enzyme and was independent of the means by which the enzyme was activated, whether by Mn2+ or proteolytically by ninhibin/GTP gamma S, suggesting it is a general characteristic of P-site-mediated inhibition. The data suggest a structure for activated adenylyl cyclase such that one nucleotide binding domain, selective for ATP vis-à-vis other ATP analogs, allosterically modulates a proximate P-site domain.
Driving passive‐matrix LCDs with low hardware complexity and reduced supply voltage (2002)

Abstract— In passive‐matrix liquid‐crystal displays (LCDs), multiplexing is achieved by using the intrinsic non‐linear characteristics of the liquid‐crystal material. If the electro‐optic characteristic is steeper than necessary for the matrix display, the selection ratio need not be maximized. Instead, the selection ratio can be reduced to match the electro‐optic characteristics of the display. This leads to a reduction in the supply voltage of the drive electronics. We have considered the possibility of using addressing techniques with low hardware complexity along with displays having steep electro‐optic characteristics. Supply voltages for these techniques are compared with that of multi‐line addressing (MLA). The supply voltages of the Hybrid Addressing Technique (HAT), Improved Hybrid Addressing Technique‐S3 (IHAT‐S3), and Improved Hybrid Addressing Technique‐S4 (IHAT‐S4) are lower than that of MLA for the lower range of N . These hybrid addressing techniques with lower hardware complexity are a better choice for driving passive‐matrix LCDs, especially in portable equipment.
ChemInform Abstract: THE DESIGN OF MULTIANIONIC CHELATING LIGANDS FOR THE PRODUCTION OF INORGANIC OXIDIZING AGENTS. OSMIUM COORDINATION CHEMISTRY THAT PROVIDES STABLE POTENT OXIDIZING AGENTS AND STABLE POTENT REDUCING AGENTS (1984)

Abstract Die strukturellen Voraussetzungen multianionischer chelatbildender Liganden (I) zur Herstellung neuer Oxidationsmittel werden diskutiert.