gebhart/patrepeval huggingface dataset:
Suppression of Angiogenesis and Resistance to Doxorubicin by the Thyroid Hormone Tetraiodothyroacetic Acid. (2007)

Abstract Thyroid hormone has been recently shown to induce tumor growth and angiogenesis. These angiogenesis modulating activities are initiated at endothelial cell plasma membrane receptor via the integrin αVβ3, at or near the Arg-Gly-Asp (RGD) recognition site on the integrin. In the present study, we have investigated the effect of tetraiodothyroacetic acid (tetrac), a deaminated thyroid hormone analog that inhibits thyroid hormone-binding to the cell surface integrin, on angiogenesis and cancer cell resistance to doxorubicin both in vitro and in vivo. Two angiogenesis models were studied in which vascular endothelial growth factor, VEGF165 or basic fibroblast growth factor, FGF2 (1–2 μg/ml) or thyroid hormone, thyroxin (L-T4 or T3) were used either to induce tube formation in the human dermal micro-vascular endothelial cells (HDMEC), or to stimulate new blood vessel branch formation in the chick chorioallantoic membrane (CAM) models. In both models, Tetrac (0.1–10 μM) inhibited the pro-angiogenesis activity of VEGF, FGF2, L-T4 or T3 by more than 50% at 1.0 uM RT-PCR revealed that tetrac (1–3 μM) decreased abundance of angiopoietin-2 mRNA but did not affect the mRNA levels of angiopoietin-1, in VEGF-exposed endothelial cells, suggesting that specific angiogenic pathways are targeted by this compound. Additionally, microarray was used to examine changes in expression of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) following VEGF treatment with and without tetrac. HDMEC cells treated with VEGF exhibited 3–5-fold increase in MMP-15 and MMP-19 expression and tetrac (3μM), inhibited expression of MMP-15 and MMP-19 by 3–9-fold, respectively. Expression of TIMP-3 was increased 5.4-fold following VEGF and tetrac treatment when compared to treatment with VEGF alone. This finding suggests that part of the mechanism by which tetrac inhibits VEGF-stimulated angiogenesis involves inhibition of certain MMPs and increase in TIMP expression. Investigation of the anti-proliferative function of tetrac was carried out using the αVβ3 expressing breast cancer cells MC7 and their drug resistant counterparts. Interestingly, proliferation of both cell lines was inhibited similarly by tetrac suggesting that this analog may circumvent drug resistance. In fact, tetrac was able to reverse resistance to doxorubicin in vitro and to suppress growth of doxorubicin resistant tumors in nude mice. Inhibition of the drug transporter p-glycoprotein was found to play a key role in mediating the action of tetrac. Taken together, findings presented in this study provide evidence that the anticancer function of tetrac can be attributed to its anti-angiogenic and drug resistance reversal activities.
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus (2016)

Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder predominantly caused by gain-of-function mutations in the protein tyrosine phosphatase SH2 domain-containing PTP (SHP2), have been shown to develop SLE, suggesting a functional correlation between phosphatase activity and systemic autoimmunity. To test this directly, we measured SHP2 activity in spleen lysates isolated from lupus-prone MRL/lpr mice and found it was markedly increased compared with that in control mice. Similar increases in SHP2 activity were seen in peripheral blood mononuclear cells isolated from lupus patients relative to healthy patients. To determine whether SHP2 alters autoimmunity and related immunopathology, we treated MRL/lpr mice with an SHP2 inhibitor and found increased life span, suppressed crescentic glomerulonephritis, reduced spleen size, and diminished skin lesions. SHP2 inhibition also reduced numbers of double-negative T cells, normalized ERK/MAPK signaling, and decreased production of IFN-γ and IL-17A/F, 2 cytokines involved in SLE-associated organ damage. Moreover, in cultured human lupus T cells, SHP2 inhibition reduced proliferation and decreased production of IFN-γ and IL-17A/F, further implicating SHP2 in lupus-associated immunopathology. Taken together, these data identify SHP2 as a critical regulator of SLE pathogenesis and suggest targeting of its activity as a potent treatment for lupus patients.
TiO<sub>2</sub> Macroscopic Fibers with Enhanced Photocatalytic Properties Obtained through a Scale‐Up Semi‐Industrial Process (2014)

We describe the generation and properties of TiO 2 ‐based macroscopic fibers designed for the photodecomposition of volatile organic compounds (VOC). We made use of a continuous industrially scalable extrusion process employing hybrid sols of amorphous titania nanoparticles, polyvinyl alcohol (PVA), and optionally latex nanoparticles. This process allowed for the continuous generation of hybrid TiO 2 /latex/PVA or TiO 2 /PVA macroscopic fibers. Upon thermal treatment in air, we obtained biphasic porous fibers containing the anatase phase of TiO 2 with 10–15% of brookite. These fibers, which can be manufactured as several hundred meters of length reels, provide significantly improved phototocatalytic efficiency compared to our previous work. Their efficiency is now comparable to the commercial Quartzel®PCO photocatalyst for gas‐phase acetone mineralization.
Effect of Cation Rotation on Charge Dynamics in Hybrid Lead Halide Perovskites (2016)

Organic–inorganic hybrid halide perovskites are a promising class of materials for photovoltaic application with reported power efficiencies over ∼22%. However, not much is known about the influence of the organic dipole rotation and phase transitions on charge carrier dynamics. Here, we report substantial changes in mobility and lifetime of charge carriers in CH3NH3PbI3 after the low-temperature tetragonal (β) to orthorhombic (γ) phase transition. By using microwave conductivity measurements, we observed that the mobility and lifetime of ionized charge carriers increase as the temperature decreases and a sudden increment is seen after the β–γ phase transition. For CH3NH3PbI3, the mobility and the half-lifetime increase by a factor of 3–6 compared with the values before the β–γ phase transition. We attribute the considerable change in the dynamics at low temperature to the decrease of the inherent dynamic disorder of the organic cation (CH3NH3+) inside the perovskite crystal structure.
Jitter generation and capture using phase-domain sigma-delta encoding (2010)

This article presents techniques and circuits for jitter generation and measurement. The proposed implementations use periodic bit-streams and high-order PLLs to generate the desired phase signal. Here, an arbitrary signal is first encoded using sigma-delta modulation in the digital amplitude-domain and converted to the phase-domain through a digital-to-time converter (DTC) process realized in software. The resulting bit-stream is inputted cyclically to a high-order phase-locked loop (PLL) behaving as a time-domain filter. The parameters of the sigma-delta modulator along with those of the high-order PLL can be traded for one another to achieve maximum performance. The method to generate the sigma-delta encoded phase signal and to design the high-order PLL is presented. A high quality Gaussian jitter signal has been experimentally generated. Also, a setup using DC encoded phase shifts serving as an under-sampling clock to measure jitter with a 50 GHz effective sampling rate has also been experimentally proven. The conciseness and digital nature of the jitter generation scheme together with the jitter measurement architecture makes them easily amenable to a design-for-test framework.
Conversion and Coding Practices for HDR/WCG ICTCP 4:2:0 Video (2017)

ICTCP is a colour difference signal representation recently standardized in Rec. ITU-R BT.2100. One design criteria of ICTCP for HDR/WCG imagery is to address issues in Non-Constant Luminance (NCL) Y'CbCr with HDR/WCG signals. In this paper, the superior performance of ICTCP in preserving constant luminance over the NCL Y'CbCr is analyzed in detail. The fundamental limitations of Y'CbCr luma adjustment algorithm which aims at fixing chroma subsampling artifact of Y'CbCr is discussed as well. This paper also provides guidance on signaling of ICTCP and feasible encoder settings with HEVC Main 10 codec. Experimental results suggest that for HDR content with real BT. 2100 (BT. 2020) colour gamut, to perform chroma subsampling and compression in ICTCP have significant value.
Combinatorially selected defense peptides protect plant roots from pathogen infection (2006)

Agricultural productivity and sustainability are continually challenged by emerging and indigenous pathogens. Currently, many pathogens can be combatted only with biocides or environmentally dangerous fumigants. Here, we report a rapid and pathogen-specific strategy to reduce infection by organisms that target plant roots. Combinatorially selected defense peptides, previously shown to effect premature encystment of Phytophthora capsici zoospores, were fused to maize cytokinin oxidase/dehydrogenase as a display scaffold. When expressed in tomato roots, the peptide-scaffold constructs were secreted and accumulated to sufficient concentrations in the rhizosphere to induce zoospore encystment and thereby deter taxis to the root surface. Pathogen infection was significantly inhibited in roots expressing bioactive peptides fused to the maize cytokinin oxidase/dehydrogenase scaffold. This peptide-delivery technology is broadly applicable for rapid development of plant defense attributes against plant pathogens.
A novel low power phase change memory using inter-granular switching (2016)

We propose and demonstrate a new low power phase change memory using a novel 3D network of crystallites with phase change confined to only at grain intersections. Contrary to conventional phase change memories, for which an entire volume of chalcogenide glass is amorphized or crystallized for high or low resistance, we propose a multi-grained structure where we only induce phase change in the inter-grain regions. This not only drastically reduces the phase change volume but also improves the thermal efficiency of the cell. 3D simulation is used to understand the local heating effect. To create the multi-grained structure we have carefully studied the Ge/Sb/Te composition, the doping material and concentration and PVD deposition conditions. Consequently, the switching current can be reduced to 20uA. Furthermore, localizing the heating also reduces thermal disturbance to neighboring cells thus provides excellent pitch scalability.
New approach for finding DOA in array antennas using cyclostationarity (2002)

A new approach is presented for estimating the directions of arrival (DOA) of desired signals in array antennas using cyclostationarity. The new algorithm can correctly estimate the DOA of desired signals by suppressing undesired signals. We apply the outputs of antenna sensors to the linear prediction model and calculate the cyclic correlation to utilize the cyclostationarity of the desired signals. We also evaluate the error of the estimate of the cyclic correlation function in the linear prediction model and correctly estimate the DOA of the desired signals. Furthermore, we take advantage of the signal selective DOA estimation to give the scheme of an adaptive beamforming. We compare our results with the results of conventional approaches in the presence of interference and at low signal to noise ratios (SNR). Numerical examples are presented to show the effectiveness of the proposed method.
Application of fluid/structure interaction to tire analysis (2002)

This paper focuses on application of fluid/structure interaction to tire analysis, such as hydroplaning analysis and prediction of tire traction on snow. Tire deformation is calculated by FEM, and fluid flow is calculated by FVM. Furthermore the fluid/structure interaction between tire and fluid is considered, in which the Lagrangian mesh (tire) and the Eulerian mesh (fluid) are defined independently and their coupling is computed. The complex fluid/structure interaction such as road/tire interaction could be analyzed. Predicted results are in good agreement with experimental data.
The cadmium binding characteristics of a lactic acid bacterium in aqueous solutions and its application for removal of cadmium from fruit and vegetable juices (2016)

A lactic acid bacterium with good cadmium binding ability can remove this heavy metal from fruit and vegetable juices efficiently.
Electrical impedance myography in the bedside assessment of inflammatory myopathy (2005)

Electrical impedance myography (EIM) is a new technique with potential for the noninvasive bedside assessment of myopathy. EIM was performed on the quadriceps of 10 patients with inflammatory myopathy and 10 normal subjects. The major EIM parameter, the spatially averaged phase, was 35% lower in the myositis patients and correlated with whole-body (r = 0.765, p = 0.01) and quadriceps (r = 0.673, p = 0.03) strength.
Studies on the Syntheses of 2 (1H)-Pyridone Derivatives. I. Synthesis and Pharmacological Property of 6-Substitued 2 (1H)-Pyridones (1979)

3- or 4-Substituted N-alkyl-6-chloro-2 (1H)-pyridones (II) were prepared from the corresponding 6-chloro-2 (1H)-pyridones (I) by alkylation. 4-Substituted N-aryl-6-halo-2 (1H)-pyridones (XII) were prepared by the condensation of N-arylpropiolamide with diethyl malonate followed by the treatment with phosphorous oxychloride and hydrolysis. II and XII were converted to 2 (1H)-pyridone derivatives having amino (III, XVIII), alkoxy (IV, XIX) or alkylthio (V) group at 6-position. Their anti-inflammatory activity and analgesic activity were examined by the inhibition of carrageenin foot edema and acetic acid writhing. Some of them showed strong activities as anti-inflammatory and analgesic agents.
Efficient Keyword Spotting Using Dilated Convolutions and Gating (2019)

We explore the application of end-to-end stateless temporal modeling to small-footprint keyword spotting as opposed to recurrent networks that model long-term temporal dependencies using internal states. We propose a model inspired by the recent success of dilated convolutions in sequence modeling applications, allowing to train deeper architectures in resource-constrained configurations. Gated activations and residual connections are also added, following a similar configuration to WaveNet. In addition, we apply a custom target labeling that back-propagates loss from specific frames of interest, therefore yielding higher accuracy and only requiring to detect the end of the keyword. Our experimental results show that our model outperforms a max-pooling loss trained recurrent neural network using LSTM cells, with a significant decrease in false rejection rate. The underlying dataset - "Hey Snips" utterances recorded by over 2.2K different speakers - has been made publicly available to establish an open reference for wake-word detection.
Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription (2015)

For therapeutic applications of siRNA, there are technical challenges with respect to targeted and systemic delivery. We here report a new siRNA carrier, RNAtr NPs, in a way that multiple tandem copies of RNA hairpins as a result of rolling circle transcription (RCT) can be readily adapted in tumour-targeted and systemic siRNA delivery. RNAtr NPs provide a means of condensing large amounts of multimeric RNA transcripts into the compact nanoparticles, especially without the aid of polycationic agents, and thus reduce the risk of immunogenicity and cytotoxicity by avoiding the use of synthetic polycationic reagents. This strategy allows the design of a platform technology for systemic delivery of siRNA to tumour sites, because RCT reaction, which enzymatically generates RNA polymers in multiple copy numbers at low cost, can lead to directly accessible routes to targeted and systemic delivery. Therefore, RNAtr NPs suggest great potentials as the siRNA therapeutics for cancer treatment.
Active load control for wind turbine blades using MEM translational tabs (2001)

Micro-electro-mechanical (MEM) translational tabs are proposed for active load control on utility-scale wind turbines. These microtabs are mounted near the trailing edge of the rotor blades, deploy approximately normal to the surface, and have a maximum deployment height on the order of the boundary-layer thickness. Deployment of this type of device effectively changes the camber on the rotor blade, thereby changing the lift generated by the surface. The effect of these tabs on lift has been shown to be as powerful as conventional control surfaces such as ailerons. Incorporation of this simple yet innovative lift enhancement and load control device with existing wind turbine power electronics and high-speed feedback sensors may permit the reduction of some of the bulky, conventional pitch control systems and result in overall reduction in system weight, complexity and cost. The minute size of these devices allows for response times much faster than conventional variable-pitch rotors allowing for improved wind turbine performance and load control at various wind speeds. This paper focuses on the experimental setup and comparison of computational and experimental data for a representative blade section. Both sets of data support previous proof of work that introduced the microtab concept and design methodology.
High efficiency wide load range buck/boost/bridge photovoltaic microconverter (2011)

Series strings of photovoltaic modules with integrated dc-dc microconverters can harvest more energy compared to conventional string-inverter architectures if the arrays are partially shaded or the modules mismatched. This work presents a multi-mode dc-dc converter as a candidate microconverter topology for photovoltaic modules. The topology constitutes a single inductor and four switching devices and can function in either buck, boost or an intermediate bridge mode based on the load. The proposed maximum power point tracking scheme is capable of tracking the true maximum even in partially-shaded PV modules. An experimental prototype demonstrates efficiency above 95 % at 215 W over a load range of 3 A to 7 A.
Binding and surface exposure characteristics of the gonococcal transferrin receptor are dependent on both transferrin-binding proteins (1996)

Neisseria gonorrhoeae is capable of iron utilization from human transferrin in a receptor-mediated event. Transferrin-binding protein 1 (Tbp1) and Tbp2 have been implicated in transferrin receptor function, but their specific roles in transferrin binding and transferrin iron utilization have not yet been defined. We utilized specific gonococcal mutants lacking Tbp1 or Tbp2 to assess the relative transferrin-binding properties of each protein independently of the other. The apparent affinities of the wild-type transferrin receptor and of Tbp1 and Tbp2 individually were much higher than previously estimated for the gonococcal receptor and similar to the estimates for the mammalian transferrin receptor. The binding parameters of both of the mutants were distinct from those of the parent, which expressed two transferrin-binding sites. Tbp2 discriminated between ferrated transferrin and apotransferrin, while Tbp1 did not. Results of transferrin-binding affinity purification, and protease accessibility experiments were consistent with the hypothesis that Tbp1 and Tbp2 interact in the wild-type strain, although both proteins were capable of binding to transferrin independently when separated in the mutants. The presence of Tbp1 partially protected Tbp2 from trypsin proteolysis, and Tbp2 also protected Tbp1 from trypsin exposure. Addition of transferrin to wild-type but not mutant cells protected Tbp1 from trypsin but increased the trypsin susceptibility of Tbp2. These observations indicate that Tbp1 and Tbp2 function together in the wild-type strain to evoke binding conformations that are distinct from those expressed by the mutants lacking either protein.
Speaker adaptation method for fenonic markov model‐based speech recognition (1991)

Abstract This paper proposes a speaker adaptation method for speech recognition based on the discrete hidden Markov models (HMM), especially the fenonic Markov model, which is a framewise model. The method consists largely of two parts—the adaptation of the vector quantization codebook and the adaptation of Markov models. The former employs a method which is based on the difference between the feature parameter distributions of the training speech and the word baseform as the basis for the adaptation, where the two are divided into N segments on the time axis. The latter employs a method based on a linear mapping, which is estimated from the matching between the quantized training speech and the word baseform. In this study, a recognition experiment was executed using 150 words with high similarities. Using the speech in which all object words are uttered ten times by a male, the codebook and the Markov models are estimated as the basis for the adaptation. Then the adaptation training is executed for seven males and four females by uttering once 25 words in the object vocabulary. The average error rate, i.e., 25.0 and 45.2 percent, respectively, for the males and females, is improved to 4.1 and 7.8 percent. Thus, the usefulness of the proposed method is demonstrated.
Novel Xylene‐Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation (2015)

Membrane proteins are key functional players in biological systems. These biomacromolecules contain both hydrophilic and hydrophobic regions and thus amphipathic molecules are necessary to extract membrane proteins from their native lipid environments and stabilise them in aqueous solutions. Conventional detergents are commonly used for membrane protein manipulation, but membrane proteins surrounded by these agents often undergo denaturation and aggregation. In this study, a novel class of maltoside-bearing amphiphiles, with a xylene linker in the central region, designated xylene-linked maltoside amphiphiles (XMAs) was developed. When these novel agents were evaluated with a number of membrane proteins, it was found that XMA-4 and XMA-5 have particularly favourable efficacy with respect to membrane protein stabilisation, indicating that these agents hold significant potential for membrane protein structural study.
Targeted advertising with inventory management (2000)

Article Free Access Share on Targeted advertising with inventory management Authors: David Maxwell Chickering Microsoft Research, Redmond, WA Microsoft Research, Redmond, WAView Profile , David Heckerman Microsoft Research, Redmond, WA Microsoft Research, Redmond, WAView Profile Authors Info & Claims EC '00: Proceedings of the 2nd ACM conference on Electronic commerceOctober 2000 Pages 145–149https://doi.org/10.1145/352871.352888Online:17 October 2000Publication History 15citation721DownloadsMetricsTotal Citations15Total Downloads721Last 12 Months20Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF