gebhart/patrepeval huggingface dataset:
Attenuation of chemotherapy-Induced neutropenia with lithium carbonate (1980)

The proposed mechanism of lithium leukocytosis, results of lithium's use in patients with neoplastic diseases, and potential benefits and risks associated with this use of lithium carbonate are discussed. The mechanism by which lithium carbonate enhances granulocyte production is thought to be via stimulation of monocyte colony-stimulating factor production, resulting in proliferation of marrow myeloid elements. Lithium carbonate effects an increase in total body neutrophil pool as well as each of its components in bone marrow and circulating pools. Typically, the drug induces a selective neutrophilic leukocytosis, peaking 7-10 days after initiating therapy lyith a return to biaseline 7-10 days after stopping the drug. The leukocytosis occurs despite the underlying neoplasm or concomitant chemotherapy regimen. Serum lithium levels of 0.5-1.0 meq/liter appear effective. Although lithium carbonate can attenuate chemotherapy-induced neutropenia and has been associated with improvement in neutrophil count and nadir, these effects remain to be translated into the clinical benefits of decreased number of infections or granulocyte transfusions and better tolerance to high-dose chemotherapy. Future clinical trials are also required to define the optimal lithium carbonate dosing regimen. The short-term neurologic and gastrpintestinal side effects are usually dose related and manageable by modifying the daily lithium dose; however, the potential long-term risks of carcinogenesis and impaired erythroc^ and lymphocyte production require further investigation.
A critical analysis of two statistical spoken dialog systems in public use (2012)

This paper examines two statistical spoken dialog systems deployed to the public, extending an earlier study on one system [1]. Results across the two systems show that statistical techniques improved performance in some cases, but degraded performance in others. Investigating degradations, we find the three main causes are (non-obviously) inaccurate parameter estimates, poor confidence scores, and correlations in speech recognition errors. We also find evidence for fundamental weaknesses in the formulation of the model as a generative process, and briefly show the potential of a discriminatively-trained alternative.
Lymphocyte activation and expression of the human leucocyte-endothelial cell adhesion molecule 1 (Leu-8/TQ1 antigen). (1990)

The Leu-8/TQ1 antigen, recently shown to be the human equivalent of the murine MEL-14 lymph node homing receptor and now designated as leucocyte-endothelial cell adhesion molecule, LECAM-1, has been used to dissect T, B and natural killer (NK) cells into various subpopulations with different functional properties, such as suppressor-inducer (CD4+ Leu-8/TQ1+) or helper (CD4+ Leu-8/TQ1-) T lymphocytes. Diminished Leu-8/TQ1 antigen density has been reported after lymphocyte activation with B- or T-cell specific stimuli for several days. In the present study, we sought to determine the signal requirements for altered Leu-8/TQ1 expression. Exposure of freshly isolated peripheral blood lymphocytes to phorbol 12-myristate 13-acetate (PMA) and/or calcium ionophores was found to cause rapid down-regulation of the Leu-8 antigen, with little or no Leu-8 reactivity remaining 1 hr after simultaneous addition of PMA and calcium ionophores to the culture medium. TQ1 reactivity was changed in parallel with that of Leu-8. Leu-8 expression of T and B cells was sensitive to both PMA and calcium ionophores, whereas Leu-8 expression of NK cells was affected by PMA but not by the calcium ionophore A23187. The effect of PMA on Leu-8/TQ1 expression could be antagonized by pretreatment with the protein kinase C inhibitor, H7, whereas that of A23187 could not. Partial re-expression of the Leu-8 antigen was seen 3 days after addition of PMA alone but not when it was given together with calcium ionophores. After Leu-8 down-regulation induced by 1 hr treatment with PMA or calcium ionophores. Leu-8 re-expression was observed within 24 hr when stimuli were removed by washing. Activation of T cells with anti-CD3 antibody resulted in a partial reduction of Leu-8/TQ1 expression, first detectable after 1-3 hr of stimulation and maximal at 24 hr. Fully mitogenmic concentrations of concanavalin A (Con A) did not affect Leu-8 expression within the first hours of culture. Transient reduction of Leu-8 expression was seen 24 hr after supraoptimal dosages of Con A, but Con A-stimulated lymphocytes cultured for 4-12 days with interleukin-2 (IL-2) retained Leu-8/TQ1 reactivity to a similar degree as fresh cells. In contrast to Leu-8/TQ1, CD45RA expression was not altered after 1 hr treatment with PMA and/or calcium ionophores but gradually disappeared during 1 week after Con A stimulation.(ABSTRACT TRUNCATED AT 400 WORDS)
An Efficient Data Warehouse for Crop Yield Prediction (2018)

Nowadays, precision agriculture combined with modern information and communications technologies, is becoming more common in agricultural activities such as automated irrigation systems, precision planting, variable rate applications of nutrients and pesticides, and agricultural decision support systems. In the latter, crop management data analysis, based on machine learning and data mining, focuses mainly on how to efficiently forecast and improve crop yield. In recent years, raw and semi-processed agricultural data are usually collected using sensors, robots, satellites, weather stations, farm equipment, farmers and agribusinesses while the Internet of Things (IoT) should deliver the promise of wirelessly connecting objects and devices in the agricultural ecosystem. Agricultural data typically captures information about farming entities and operations. Every farming entity encapsulates an individual farming concept, such as field, crop, seed, soil, temperature, humidity, pest, and weed. Agricultural datasets are spatial, temporal, complex, heterogeneous, non-standardized, and very large. In particular, agricultural data is considered as Big Data in terms of volume, variety, velocity and veracity. Designing and developing a data warehouse for precision agriculture is a key foundation for establishing a crop intelligence platform, which will enable resource efficient agronomy decision making and recommendations. Some of the requirements for such an agricultural data warehouse are privacy, security, and real-time access among its stakeholders (e.g., farmers, farm equipment manufacturers, agribusinesses, co-operative societies, customers and possibly Government agencies). However, currently there are very few reports in the literature that focus on the design of efficient data warehouses with the view of enabling Agricultural Big Data analysis and data mining. In this paper ...
Immune response to virus-infection-associated (VIA) antigen in cattle repeatedly vaccinated with foot-and-mouth disease virus inactivated by formalin or acetylethyleneimine (1979)

SUMMARY The results of experiments to investigate antibody to ‘virus infection associated’ (VIA) antigen in cattle repeatedly vaccinated with formalin- or acetylethyleneimine- (AEI) inactivated foot-and-mouth disease (FMD) vaccines under laboratory conditions are reported. Results are also presented from some vaccinated animals subsequently exposed to FMD infection. Antibody against VIA was not detected before and after the first vaccination with formalin or AEI-inactivated vaccine but did develop in all animals after the second formalin vaccination and persisted throughout the experiment. After the second AEI vaccination, 4 of 12 animals developed antibody which persisted for at least 37 days. This transient response in some cattle was repeated after successive vaccinations but, in general, more animals responded as the number of vaccinations increased. After exposure to infection, a transient VIA antibody response was occasionally observed in immune AEI-vaccinated animals. Some immune repeatedly AEI-vaccinated cattle did not develop detectable VIA antibody after challenge despite the persistence of virus in oesophageal–pharyngeal (O/P) fluid. The presence of antibody to VIA antigen is not conclusive proof that vaccinated animals have been exposed to infection and field data must be interpreted with caution.
Membrane-Permeable Mn(III) Complexes for Molecular Magnetic Resonance Imaging of Intracellular Targets (2016)

Intracellular compartments make up roughly two-thirds of the body, but delivery of molecular imaging probes to these spaces can be challenging. This situation is particularly true for probes designed for detection by magnetic resonance imaging (MRI), a high-resolution but relatively insensitive modality. Most MRI contrast agents are polar and membrane impermeant, making it difficult to deliver them in sufficient quantities for measurement of intracellular analytes. Here we address this problem by introducing a new class of planar tetradentate Mn(III) chelates assembled from a 1,2-phenylenediamido (PDA) backbone. Mn(III)-PDA complexes display T1 relaxivity comparable to that of Gd(III)-based contrast agents and undergo spontaneous cytosolic localization via defined mechanisms. Probe variants incorporating enzyme-cleavable acetomethoxy ester groups are processed by intracellular esterases and accumulate in cells. Probes modified with ethyl esters preferentially label genetically modified cells that express a substrate-selective esterase. In each case, the contrast agents gives rise to robust T1-weighted MRI enhancements, providing precedents for the detection of intracellular targets by Mn(III)-PDA complexes. These compounds therefore constitute a platform from which to develop reagents for molecular MRI of diverse processes inside cells.
NumChecker (2013)

This paper presents NumChecker, a new Virtual Machine Monitor (VMM) based framework to detect control-flow modifying kernel rootkits in a guest Virtual Machine (VM). NumChecker detects malicious modifications to a system call in the guest VM by checking the number of certain hardware events that occur during the system call's execution. To automatically count these events, NumChecker leverages the Hardware Performance Counters (HPCs), which exist in most modern processors. By using HPCs, the checking cost is significantly reduced and the tamper-resistance is enhanced. We implement a prototype of NumChecker on Linux with the Kernelbased Virtual Machine (KVM). Our evaluation demonstrates its practicality and effectiveness.
[Flooding Dallas, TX] (1980)

Photograph of a Dallas Fire Department boat being towed by a fire truck during a flood. A man in uniform stands on the boat, directing another man who appears to be attaching the boat to the fire truck.
A comparison of acoustic-prosodic entrainment in face-to-face and remote collaborative learning dialogues (2014)

Today, people are just as likely to have a business meeting remotely as they are face-to-face. Individuals obtain college degrees remotely and sick patients can visit the doctor from home. Especially important in light of this popularity, remote settings are posing communication challenges that are not present in face-to-face settings. Visual cues such as facial expressions and body language are either degraded or nonexistent. In this paper, we are interested in how remote settings affect spoken dialogue when compared to face-to-face settings. We focus on entrainment, a phenomenon of conversation where individuals adapt to each other during the interaction. Specifically, we investigate acoustic-prosodic entrainment, where individuals become more similar in their pitch, loudness, or speaking rate. We explore three different measures of acoustic-prosodic entrainment, comparing remote settings to face-to-face settings on a turn-by-turn basis. Our results indicate that the two settings do differ for different forms of entrainment, suggesting that the presence or absence of visual cues such as facial expressions and body language has an impact on the degree of entrainment.
Fabrication of air-channel structures for microfluidic, microelectromechanical, and microelectronic applications (2001)

A method is presented for fabricating micro-air-channel structures encapsulated by a dielectric material using a sacrificial polymer based on polynorbornene (PNB) chemistry. A spin-coated film of PNB was patterned to define the exact geometry of the air-channels using conventional lithographic and etching techniques. The sacrificial polymer was encapsulated with a permanent dielectric material. The composite was then raised to elevated temperatures to produce gaseous products which permeate through the encapsulating material (SiO/sub 2/, SiN/sub x/ or other polymer) leaving behind minimal solid residue. Air-channels integrated with metal interconnections can be formed via a Damascene, or in-lay process. After patterning the sacrificial polymer, copper was electroplated, followed by encapsulation with the dielectric. Various issues pertaining to the processing steps have been investigated and are discussed, such as type of encapsulants, feasible air-channel sizes, and processing conditions. Such air-channel structures are believed to have potential applications in microelectronics, displays, printers, multilevel wiring boards, microscale chemical reactors on a chip, and microelectromechanical devices.
Polypeptide Nanogels With Different Functional Cores Promote Chemotherapy of Lung Carcinoma (2019)

Two kinds of tumor microenvironment-responsive polypeptide nanogels were developed for intracellular delivery of cytotoxics to enhance the antitumor efficacies and reduce the side effects in the chemotherapy of lung carcinoma. The sizes of both doxorubicin (DOX)-loaded nanogels methoxy poly(ethylene glycol)-poly(L-phenylalanine-<i>co</i>-L-cystine) [mPEG-P(LP-<i>co</i>-LC)] and methoxy poly(ethylene glycol)-poly(L-glutamic acid-<i>co</i>-L-cystine) [mPEG-P(LG-<i>co</i>-LC)] (NGP/DOX and NGG/DOX) were less than 100 nm, which was appropriate for the enhanced permeability and retention (EPR) effect. The bigger and smaller scale of nanoparticle could induce the elimination of reticuloendothelial system (RES) and decrease the <i>in vivo</i> circulating half-life, respectively. The loading nanogels were stable in the neutral environment while quickly degraded in the mimic intracellular microenvironment. Furthermore, the DOX-loaded reduction-responsive nanogels showed significantly higher tumor cell uptake than free DOX⋅HCl as time went on from 2 to 6 h. In addition, these DOX-loaded nanogels showed efficient antitumor effects <i>in vivo</i>, which was verified by the obviously increased necrosis areas in the tumor tissues. Furthermore, these DOX-loaded nanogels efficiently reduced the side effects of DOX. In conclusion, these reduction-responsive polypeptides based nanogels are suitable for the efficient therapy of lung carcinoma.
Analysis of Droplet Spectra and Spray Recovery as a Function of Atomizer Type and Fluid Physical Properties (1983)

Drop size, as indicated by the volume median diameter (VMD), and size uniformity, noted by the relative span (RS), were correlated with (1) viscosity, (2) surface tension, (3) viscoelasticity, and also (4) liquid throughput. Two types of nozzles were used, simple orifices or jets and hollow cones. The density of the mixtures did not vary greatly and no correlations were made with this function. Increased liquid throughput (increased orifice diameter) showed significant effects on drop size, increasing the VMD as the orifice size increased for all nozzles and mixtures tested. Of the liquid properties, viscoelasticity had the greatest effect, increasing drop size as it was increased. Increasing the surface tension increased drop size significantly, but changes in viscosity appeared to have little effect on the drop size produced. The RS was reduced (narrow range) as surface tension, viscosity, and viscoelasticity were increased. Increased throughput reduced RS at two surface tension levels, but when the viscoelastic polymer was used, the increased throughput actually increased the RS for the nozzles tested. The atomization process is very complex and the study using kromkote paper collection cards could have benefited significantly if the new Particle Measuring Systems Co. (PMS) in situ system had been available. Nonetheless, the data have considerable relevance to pesticide spray atomization. Further advances will be made as the PMS or similar scanners become more widely available.
An efficient timing-driven global routing algorithm (1993)

In this paper, we propose an eflicient timing-driven global routing algorithm. Unlike other conventional global routing techniques, interconnection delays
An evidence based protocol for the prevention of upper arm injury related to vaccine administration (UAIRVA) (2011)

Upper arm injury related to vaccine administration (UAIRVA) is an infrequent but increasingly recognised complication of deltoid muscle vaccination. Vaccine administration reported injury to the subdeltoid/subacromial bursa, anterior branch of the axillary nerve and the radial nerve presumably reflects the lack of awareness of the anatomical position of these structures in and near this muscle and the multiplicity of methods for the selection of the injection site in the muscle. An evidence based protocol for safe vaccine administration into the deltoid muscle is presented. This was developed using anthropometric measurements of the surface anatomical landmarks in adults who regularly receive intramuscular injection of vaccines into the deltoid muscle (adults ≥ 65 years old) and mapping the position of structures potentially injured by injection observed in ultrasonographic and cadaveric studies. The mid point of the muscle (midway between the acromion and the deltoid tuberosity) with the arm abducted to 60° is a safe site for injection. The protocol for vaccine administration in this way involves the vaccinee placing the hand on the ipsilateral hip with the vaccinator then placing their index finger on the acromion and their thumb on the deltoid tuberosity and administering the vaccine at midpoint between these anatomical landmarks.
Integrated multimodal microscopy, time-resolved fluorescence, and optical-trap rheometry: toward single molecule mechanobiology (2007)

Cells respond to forces through coordinated biochemical signaling cascades that originate from changes in single-molecule structure and dynamics and proceed to large-scale changes in cellular morphology and protein expression. To enable experiments that determine the molecular basis of mechanotransduction over these large time and length scales, we construct a confocal molecular dynamics microscope (CMDM). This system integrates total-internal-reflection fluorescence (TIRF), epifluorescence, differential interference contrast (DIC), and 3-D deconvolution imaging modalities with time-correlated single-photon counting (TCSPC) instrumentation and an optical trap. Some of the structures hypothesized to be involved in mechanotransduction are the glycocalyx, plasma membrane, actin cytoskeleton, focal adhesions, and cell-cell junctions. Through analysis of fluorescence fluctuations, single-molecule spectroscopic measurements [e.g., fluorescence correlation spectroscopy (FCS) and time-resolved fluorescence] can be correlated with these subcellular structures in adherent endothelial cells subjected to well-defined forces. We describe the construction of our multimodal microscope in detail and the calibrations necessary to define molecular dynamics in cell and model membranes. Finally, we discuss the potential applications of the system and its implications for the field of mechanotransduction.
CaV3.2 T-Type Calcium Channels in Peripheral Sensory Neurons Are Important for Mibefradil-Induced Reversal of Hyperalgesia and Allodynia in Rats with Painful Diabetic Neuropathy (2014)

We recently showed that streptozotocin (STZ) injections in rats lead to the development of painful peripheral diabetic neuropathy (PDN) accompanied by enhancement of CaV3.2 T-type calcium currents (T-currents) and hyperexcitability in dorsal root ganglion (DRG) neurons. Here we used the classical peripherally acting T-channel blocker mibefradil to examine the role of CaV3.2 T-channels as pharmacological targets for treatment of painful PDN. When administered intraperitoneally (i.p.), at clinically relevant doses, mibefradil effectively alleviated heat, cold and mechanical hypersensitivities in STZ-treated diabetic rats in a dose-dependent manner. We also found that CaV3.2 antisense (AS)-treated diabetic rats exhibit a significant decrease in painful PDN compared with mismatch antisense (MIS)-treated diabetic rats. Co-treatment with mibefradil (9 mg/kg i.p.) resulted in reversal of heat, cold and mechanical hypersensitivity in MIS-treated but not in AS-treated diabetic rats, suggesting that mibefradil and CaV3.2 AS share the same cellular target. Using patch-clamp recordings from acutely dissociated DRG neurons, we demonstrated that mibefradil similarly blocked T-currents in diabetic and healthy rats in a voltage-dependent manner by stabilizing inactive states of T-channels. We conclude that antihyperalgesic and antiallodynic effects of mibefradil in PDN are at least partly mediated by inhibition of CaV3.2 channels in peripheral nociceptors. Hence, peripherally acting voltage-dependent T-channel blockers could be very useful in the treatment of painful symptoms of PDN.
Randomized Shellsort: a simple oblivious sorting algorithm (2010)

In this paper, we describe a randomized Shellsort algorithm. This algorithm is a simple, randomized, data-oblivious version of the Shellsort algorithm that always runs in O(n log n) time and succeeds in sorting any given input permutation with very high probability. Taken together, these properties imply applications in the design of new efficient privacy-preserving computations based on the secure multi-party computation (SMC) paradigm. In addition, by a trivial conversion of this Monte Carlo algorithm to its Las Vegas equivalent, one gets the first version of Shellsort with a running time that is provably O(n log n) with very high probability.
Experimental ultraviolet photocarcinogenesis: wavelength interactions and time-dose relationships. (1978)

Tumors were induced in the skin of SKH hairless mice by exposure to fluorescent FS sun lamps or to a long-arc xenon solar simulator. Tumores developed about equally well with varying amounts of UV-A radiation (lambda greater than 320 nm) given simultaneously. In contrast, incremental changes in the UV-B region (lambda less than 320 nm) led to substantial increases in carcinogenic effectiveness. A tumor-"initiating" dose of UV-B (4-10 wk of daily FS lamp exposures) was rendered less effective by subsequent exposures of the mice to UV-A (6 hr/day, F-40 T12BL lamps). The mechanism for this effect is not known. Most tumors induced by a short course (10 wk) of FS lamp exposure grew slowly or regressed, whereas mice exposed for a longer period (30 wk) developed more tumors, and many of those that appeared early grew aggressively. Effects of daily dose fractionation were less clear, and the subject requires further study. These and other variables are being tested in a program designed to yield useful information on the effects of changing spectrum, dose, and dose delivery rates on sunlight-induced cancer.
Next-generation peptide nanomaterials: molecular networks, interfaces and supramolecular functionality (2010)

With improved understanding of the design rules for self-assembling peptides, new challenges will be faced to incorporate these materials into dynamic systems of higher complexity and functionality. In this highlight article we discuss very recent advances in these areas. Three areas are covered: (i) molecular networks based on peptides and their interactions including (bio-) catalytically driven systems; (ii) supramolecular functionality, both in the context of biological and nanotechnology applications; (iii) approaches to effectively interface peptides with synthetic and biological materials. We also discuss challenges and opportunities for the design of a new generation of peptide nanomaterials for the next decade.