gebhart/patrepeval huggingface dataset:
Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy (2016)

Purpose. In this study, we evaluated our experience with salvage brachytherapy after discovery of biochemical recurrence after a prior brachytherapy procedure. Methods and Materials. From 2001 through 2012 twenty-one patients treated by brachytherapy within University of Kentucky or from outside centers developed biochemical failure and had no evidence of metastases. Computed tomography (CT) scans were evaluated; patients who had an underseeded portion of their prostate were considered for reimplantation. Results. The majority of the patients in this study (61.9%) were low risk and median presalvage PSA was 3.49 (range 17.41-1.68). Mean follow-up was 61 months. At last follow-up after reseeding, 11/21 (52.4%) were free of biochemical recurrence. There was a trend towards decreased freedom from biochemical recurrence in low risk patients (p = 0.12). International Prostate Symptom Scores (IPSS) increased at 3-month follow-up visits but decreased and were equivalent to baseline scores at 18 months. Conclusions. Salvage brachytherapy after primary brachytherapy is possible; however, in our experience the side-effect profile after the second brachytherapy procedure was higher than after the first brachytherapy procedure. In this cohort of patients we demonstrate that approximately 50% oncologic control, low risk patients appear to have better outcomes than others.
High-performance combinatorial optimization based on classical mechanics (2021)

Quickly obtaining optimal solutions of combinatorial optimization problems has tremendous value but is extremely difficult. Thus, various kinds of machines specially designed for combinatorial optimization have recently been proposed and developed. Toward the realization of higher-performance machines, here, we propose an algorithm based on classical mechanics, which is obtained by modifying a previously proposed algorithm called simulated bifurcation. Our proposed algorithm allows us to achieve not only high speed by parallel computing but also high solution accuracy for problems with up to one million binary variables. Benchmarking shows that our machine based on the algorithm achieves high performance compared to recently developed machines, including a quantum annealer using a superconducting circuit, a coherent Ising machine using a laser, and digital processors based on various algorithms. Thus, high-performance combinatorial optimization is realized by massively parallel implementations of the proposed algorithm based on classical mechanics.
Identification of FGF10 Targets in the Embryonic Lung Epithelium during Bud Morphogenesis (2004)

Genetic studies implicate Fgf10-Fgfr2 signaling as a critical regulator of bud morphogenesis in the embryo. However, little is known about the transcriptional targets of Fgf10 during this process. Here we identified global changes in gene expression in lung epithelial explants undergoing FGF10-mediated budding in the absence of other growth factors and mesenchyme. Targets were confirmed by their localization at sites where endogenous Fgf10 signaling is active in embryonic lungs and by demonstrating their induction in intact lungs in response to local application of FGF10 protein. We show that the initial stages of budding are characterized by marked up-regulation of genes associated with cell rearrangement and cell migration, inflammatory process, and lipid metabolism but not cell proliferation. We also found that some genes implicated in tumor invasion and metastatic behavior are epithelial targets of Fgf10 in the lung and other developing organs that depend on Fgf10-Fgfr2 signaling to properly form. Our approach identifies Fgf10 targets that are common to multiple biological processes and provides insights into potential mechanisms by which Fgf signaling regulates epithelial cell behavior.
The Radical South (2018)

This chapter explores the engagement of Southern lesbian feminists with radical politics and Southern identity, with a particular focus on anti-racist coalitions and nascent intersectional feminist alliances.
[ <sup>11</sup> C]( <i>R</i> )-PK11195 PET imaging of microglial activation in multiple system atrophy (2003)

Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA.
Views of media objects in multimedia databases (2002)

Multimedia database systems must manage large amounts of graphical, textual, and audio data. To compound the problem, if a multimedia designer creates a new media image from an existing item, current systems store the new object as an independent image. This space is wasted since the data already exists in the system. In order to eliminate this wasted space, views of stored objects should be used instead of replicated data. Views are well known in relational databases to have both benefits and drawbacks. In order to overcome these drawbacks, the paper defines a view schema, which mirrors the media hierarchy; a view dag which determines the base files used to create the view; and view independence, a paradigm for performing operations on views. The criteria for a canonical media algebra are outlined. A canonical media algebra allows multiple editors to instantiate a view. Finally, optimization of specifications is discussed.
An Organophosphorus(III)-Selective Chemodosimeter for the Ratiometric Electrochemical Detection of Phosphines (2019)

The high toxicity of phosphine and the use of organophosphines as nerve agent precursors has provoked the requirement for a rapid and reliable detection methodology for their detection. Herein, we demonstrate that a ferrocene-derived molecular probe, armed with an azidobenzene trigger, delivers a ratiometric electrochemical signal selectively in response to organophosphorus(III) compounds and can be accurately measured with an inexpensive, handheld potentiostat. Through an intensive assay optimization process, conditions were found that could determine the presence of a model organophosphine(III) nerve agent precursor within minutes and achieved a limit of detection for triphenylphosphine of just 13 ppm. Due to the portability of the detection system and the excellent stability of the probe in solution, we envisaged that this proof-of-concept of work could easily be taken into the field to enable potentially toxic organophosphorus(III) compounds to be detected at the point-of-need.
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule (2018)

Protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) is a brain specific phosphatase that regulates synaptic function and plasticity by modulation of N-methyl-d-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking. Dysregulation of STEP has been linked to neurodegenerative and neuropsychiatric diseases, highlighting this enzyme as an attractive therapeutic target for drug discovery. Selective targeting of STEP with small molecules has been hampered by high conservation of the active site among protein tyrosine phosphatases. We report the discovery of the first small molecule allosteric activator for STEP that binds to the phosphatase domain. Allosteric binding is confirmed by both X-ray and <sup>15</sup>N NMR experiments, and specificity has been demonstrated by an enzymatic test cascade. Molecular dynamics simulations indicate stimulation of enzymatic activity by a long-range allosteric mechanism. To allow the scientific community to make use of this tool, we offer to provide the compound in the course of an open innovation initiative.
Quasistatic processes as step equilibrations (1985)

The proportionality between the square of the distance traversed as measured in thermodynamic length and the minimum associated dissipation of a process is established in a new context independent of dynamical laws. A quasistatic thermodynamic process consisting of K steps, each equilibrating with an appropriate reservoir, is optimized with respect to the position of the steps and the allocation of the total time τ for the process among the steps. It is found that the steps should be of equal thermodynamic length. For large K the bounds based on thermodynamic length are recovered.
Recombinant Human Bone Morphogenetic Protein-2 in Posterolateral Spinal Fusion: What's the Right Dose? (2016)

Previous recommendation of 20 mg/level of rhBMP-2 is more than what is required for predictable fusion rates of 98%. No dose related increase of infection, seroma formation, and bone overgrowth has been found. In order to provide variable dosing and cost reduction, industry generated rhBMP-2 kit size should be optimized.
Differential effects of small tumour necrosis factor-alpha peptides on tumour cell cytotoxicity, neutrophil activation and endothelial cell procoagulant activity. (1993)

Tumour necrosis factor-alpha (TNF-alpha) is a pluripotent cytokine with its receptors distributed throughout many different cell types. Because of the diverse effects of the cytokine, it is difficult to clearly define its role in infection and immunity, and appreciate its clinical therapeutic value. We have identified peptides derived from the primary amino acid sequence of human TNF-alpha that have neutrophil-stimulating activity, as measured by enhanced chemiluminescence and superoxide production, and peptides which are both directly cytotoxic for tumour cells (WEHI-164) in vitro and also prevent TNF binding to tumour cells. However, only one of these neutrophil-stimulating peptides was toxic for tumour cells in vitro. Our results indicate that the region of amino acids 54-94 of human TNF-alpha has previously undescribed human neutrophil-stimulatory activity, while peptides encompassing the regions 43-68 and 132-150, which are in close proximity, as indicated in the recently determined three-dimensional structure of human TNF-alpha, have in vitro anti-tumour activity. These peptides also slowed tumour growth or induced tumour regression in WEHI-164 tumour-bearing mice. The peptide 73-94, which activated neutrophils but which was not cytotoxic for tumour cells in vitro, also caused in vivo tumour regression, presumably by activating neutrophils with the consequent release of free radicals at the tumour site. Peptide 63-83, which was able to activate neutrophils in vitro, did not possess tumour regression activity in vivo. The TNF peptides described in this report did not elicit procoagulant activity in cultured bovine aortic endothelial cells and as such are devoid of at least one of the potentially lethal side-effects of elevated TNF levels in vivo.
Une affaire de dignité (1994)

UNE AFFAIRE DE DIGNITÉ Un jeudi, au Nord, dans la nuit.Il vente.Les fenêtres de Kuujjuaq claquent.Il a neigé au cours de la journée.Premières nuées blanches de novembre effaçant la grisaille du sable et le sombre des épinettes chenues.Dans un appartement, au deuxième étage d'un édifice appartenant au centre hospitalier, une sonnerie de téléphone jette Richard Munro en bas de son lit.Dans la cuisine, il décroche le combiné.La voix d'une infirmière, lointaine, lui annonce une urgence.Médecin de garde pour les appels nocturnes, Munro écoute en frottant son oeil droit qui pique.En fin de soirée, une jeune femme s'est présentée au dispensaire de Kangiqsualujjuaq, trois cent cinquante kilomètres au nord-est.Elle se plaignait d'un mal de tête aussi violent que subit.Elle fut placée sous observation.Elle vomit, devint somnolente, puis perdit conscience.Maintenant, sa pupille droite, agrandie, réagit moins à la lumière.Munro frissonne.L'hiver, bien installé de l'autre côté du verre, puise ses rayonnements indigo.Munro s'assoit, le combiné contre l'oreille, devant une fenêtre marquée de dizaines d'arabesques givrées, devant la toundra qui s'étale sur des milliers de kilomètres carrés jusqu'au pied des monts Torngat.La lune, à moitié pleine, renvoie en flaques jaunâtres des pans de clarté sur la rivière Koksoaq.Richard Munro ne s'est encore jamais rendu à Kangiqsualujjuaq.Il consulte sa montre, cherche une réponse pour l'infirmière qu'il sent fébrile à l'autre bout du fil.Tout paraît suffisamment clair : la patiente, venue sombrer dans le coma à la clinique de son village, a été victime d'un anévrysme.Explosion, hémorragie cérébrale brutale et massive.Mauvais pronostic, à cause du temps qui s'écoulera plus vite à partir de maintenant.L'infirmière lui annoncera-t-elle que la malade a cessé de respirer?Vraisemblable destin pour quelqu'un qui n'avait jamais ressenti le moindre mal de tête, qui se portait relativement bien cinq heures auparavant.Un caillot noirâtre, entouré d'oedème, prend entre les os inextensibles une place qui ne lui a jamais été réservée.Munro se gratte le front.«Trente et un ans?» Faut faire chuter la pression intra-crânienne.«Vous PRINTEMPS 1994, VOL 4 NO 2 avez du Décadron, du Mannitol?»demande-t-il, les yeux fixés sur le clair-obscur du paysage.Tout un pays, du sud à son nord le plus extrême, devra être mis en état d'éveil pour le transport de cette femme.Branle-bas de combat afin de ramener vers Kuujjuaq et, ensuite, peut-être, la diriger vers un hôpital où un neurochirurgien pourra intervenir... Peut-être.Tentative des vivants pour permettre à une comateuse d'échapper à la mort.«Je vous rappelle dans dix minutes».3 h 43.Pas de réponse dans les locaux de la compagnie aérienne à Kuujjuaq.Munro doit alerter la régie, à Radisson.De là, les pilotes seront mis en alerte.Plusieurs sonneries plus tard, à 1 300 kilomètres au sud de Kuujjuaq, un homme répond.Munro s'explique : «Besoin d'un avion pour Kangiqsualujjuaq».L'homme toussote, marmonne quelque chose d'incompréhensible.Munro entend craquer les ressorts d'un lit.«O.k.Je les appelle».
An Efficient RAN Slicing Strategy for a Heterogeneous Network With eMBB and V2X Services (2019)

Emerging 5G wireless technology will support services and use cases with vastly heterogeneous requirements. Network slicing, which allows composing multiple dedicated logical networks with specific functionality running on top of a common infrastructure, is introduced as a solution to cope with this heterogeneity. At the radio access network (RAN), the use of network slicing involves the assignment of radio resources to each slice in accordance with its expected requirements and functionalities. Therefore, RAN slicing will provide the required design flexibility and will be necessary for any network slicing solution. This paper investigates the RAN slicing problem for providing two generic services of 5G, namely enhanced mobile broadband (eMBB) and vehicle-to-everything (V2X). In this respect, we propose an efficient RAN slicing scheme based on an off-line reinforcement learning followed by a low-complexity heuristic algorithm, which allocates radio resources to different slices with the target of maximizing the resource utilization while ensuring the availability of resources to fulfill the requirements of the traffic of each RAN slice. A simulation-based analysis is presented to assess the performance of the proposed solution. The simulation results have shown that the proposed algorithm improves the network performance in terms of resource utilization, the latency of V2X services, achievable data rate, and outage probability.
Reaction of Ammonia with Fumed Silica (1990)

The reaction between fumed silica and ammonia has been studied between 600° and 1200°C. Up to 24 wt% nitrogen can be introduced into vitreous silica by adjusting the partial pressure of ammonia, temperature, and reaction time. The experiments show that the amount of nitrogen incorporated into silica has a linear dependence on the partial pressure of ammonia and a square root dependence on the reaction time. The activation energy for the reaction was found to be 76.0 kJ/mol. The nitrided powders as well as several hotpressed samples were crystallized at 1550° to 1650°C. Silica glasses containing 0 to 1 wt% nitrogen crystallize to cristobalite. Glasses containing 2 to 10 wt% nitrogen are stable against devitrification in nitrogen, even at 1650°C. Glasses with 12 to 28 wt% nitrogen crystallize to fine‐grained Si 2 N 2 O with residual glass.
Reliable and load balance-aware multi-controller deployment in SDN (2018)

Software Defined Networking (SDN) provides flexible network management by decoupling control plane and data plane. However, such separation introduces the issues regarding the reliability of the control plane and controller load imbalance in the distributed SDN network, which will cause the low network stability and the poor controller performance. This paper proposes Reliable and Load balance-aware Multi-controller Deployment (RLMD) strategy to address the above problems. Firstly, we establish a multiple-controller network model and define the relevant parameters for RLMD. Then, we design the corresponding algorithms to implement this strategy. By weighing node efficiency and path quality, Controller Placement Selection (CPS) algorithm is introduced to explore the reliable deployments of the controllers. On this basis, we design Multiple Domain Partition (MDP) algorithm to allocate switches for controllers according to node attractability and controller load balancing rate, which could realize the reasonable domain planning. Finally, the simulations show that, compared with the typical strategies, RLMD has the better performance in improving the reliability of the control plane and balancing the distribution of the controller loads.
Statin potency associated with incident diabetes in a real-world evaluation (2013)

Commentary on: Carter AA, Gomes T, Camacho X, et al. Risk of incident diabetes among patients treated with statins: population based study. BMJ 2013;346:f2610[OpenUrl][1][Abstract/FREE Full Text][2] For widely prescribed medications, such as statins, even the development of uncommon adverse events may have significant public health ramifications. Recent meta-analyses of randomised controlled trials (RCTs) have demonstrated an increased incidence of diabetes in patients taking statins. These have demonstrated a dose–effect relationship, but whether different statins have differential effects on the risk of diabetes is still unclear. In this study, Carter and colleagues further investigate the dose–effect relationship of statin-induced diabetes and whether different statins carry distinct risks of diabetes in a large, real-world population. The authors examined healthcare records of more than 1.5 million adults aged 66 years or above in Ontario, Canada from August 1997 to March 2010. The analysis excluded patients with established diabetes and those prescribed a statin within 1 year prior to the start of the study. Linked administrative healthcare databases were used to provide information on … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.f2610%26rft_id%253Dinfo%253Apmid%252F23704171%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=bmj&resid=346/may23_4/f2610&atom=%2Febmed%2F19%2F2%2F68.atom
LASS6, an additional member of the longevity assurance gene family (2005)

Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. In an effort to characterize additional members of the LAG family, we have screened the latest releases of genomic databases and report on the bioinformatic characterization of yet another member, LAG1 longevity assurance homolog 6 (LASS6). Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. In phylogenetic analyses, it displayed highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Orthologous sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates as the protein and corresponding genomic sequences were highly conserved. LASS6 expression was analyzed in silico, and the gene was shown to be broadly expressed in a wide range of tissues. Furthermore, available microarray data suggested a role in cancer differentiation and early embryonic development.
A modelling technique for inter-domain management (2002)

Inter-domain management is a hot topic with regard to the ever-increasing importance of the Internet. Different service providers co-operate in order to supply end-to-end services for customers. This co-operation must be controlled by a co-operative network, system, service and application management. There are several standards dealing with single aspects of inter-domain management. However, a globally applicable specification technique has not been standardized yet, and thus, these standards remain mostly incomparable. Therefore, this paper introduces a compact and easy-to-handle modelling technique for inter-domain management to be used to illustrate, specify and compare processes of inter-domain management.
A Shuffle-Exchange Network with Simplified Control (1976)

In this paper, a control mechanism for a shuffle-exchange interconnection network of N cells is proposed. With this network it is possible to realize some important permutations in log <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> N shuffle-exchange steps. In the control mechanism presented, the control variables at step k are determined by a Boolean operation of the control variables at step k - 1. The Boolean operation is very simple so that little additional hardware is required for this computation. This control scheme requires only one bit per cell instead of a destination tag of log <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> N bits required by a control mechanism presented previously. The network can be used for the interconnection of memory modules and processors in an array computer, and for the accessing of blocks of consecutive data in large dynamic memories. It is also shown that the shuffle-exchange interconnection network permits the efficient partitioning of an array computer into subarrays to allow for the simultaneous computation of several identical problems.
Magnetoresistance effect of La0.72Ca0.25MnO<i>z</i>/YBa2Cu3O<i>y</i>/La0.72Ca0.25 MnO<i>z</i> trilayered films (1993)

The magnetoresistance (MR) effects of La0.72Ca0.25MnOz (LCMO) magnetic films and LCMO/YBa2Cu3Oy (YBCO)/LCMO trilayered films were studied. The LCMO films have an MR ratio of −4% when applying 1 T at 77 K and this value is independent of the film thickness from 1500 to 4500 Å. In contrast to that, the MR ratio for LCMO/YBCO/LCMO films depends on the thickness of the YBCO layer and is more than 1.5 times as large as that for LCMO films when the thickness of the YBCO layer is less than 2500 Å. These results imply that the magnetic spin interaction between the two LCMO layers may exist through the normal-conductive state YBCO layer.