gebhart/patrepeval huggingface dataset:
Bis(pentafluorophenyl)borinic Acid as a Highly Effective Oppenauer Oxidation Catalyst for Allylic and Benzylic Alcohols (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTBis(pentafluorophenyl)borinic Acid as a Highly Effective Oppenauer Oxidation Catalyst for Allylic and Benzylic AlcoholsKazuaki Ishihara, Hideki Kurihara, and Hisashi YamamotoView Author Information Graduate School of Engineering, Nagoya University, Research Center for Advanced Waste and Emission Management (ResCWE), Nagoya University, and CREST, Japan Science and Technology Corporation (JST), Chikusa, Nagoya 464-01, JapanCite this: J. Org. Chem. 1997, 62, 17, 5664–5665Publication Date (Web):August 22, 1997Publication History Received2 June 1997Published online22 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/jo970959dhttps://doi.org/10.1021/jo970959drapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1770Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Additives,Alcohols,Catalysts,Mixtures,Oxidation Get e-Alerts
Base‐Promoted Reactions of Bridged Ketones and 1,3‐ and 1,4‐Haloalkyl Azides: Competitive Alkylation vs Azidation Reactions of Ketone Enolates. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Multi-Cast Key Distribution: Scalable, Dynamic and Provably Secure Construction. (2016)

In this paper, we propose a two-round dynamic multi-cast key distribution (DMKD) protocol under the star topology with a central authentication server. Users can share a common session key without revealing any information of the session key to the server and can join/leave to/from the group at any time even after establishing the session key. Our protocol is scalable because communication and computation costs of each user are independent from the number of users. Also, our protocol is still secure if either private key or session-specific randomness of a user is exposed. Furthermore, time-based backward secrecy is guaranteed by renewing the session key for every time period even if the session key is exposed. We introduce the first formal security definition for DMKD under the star topology in order to capture such strong exposure resilience and time-based backward secrecy. We prove that our protocol is secure in our security model in the standard model.
Short term GNSS clock characterization using One-Way carrier phase (2007)

A major effort has been done over the last years to use the carrier phase of GPS satellites signals for time transfer. Several techniques have been proposed by developing dedicated algorithms for common view time transfer, orbit and time network adjustments or precise point positioning. Such techniques have been widely and successfully used for clock comparison and dissemination, and for the characterization of on-board clocks. In particular, GPS clocks characterization is carried out by network analysis techniques by the USNO, NRL, NGA and IGS analysis centres. It is based on the processing of GPS observables gathered over wide network of sensor stations and therefore requires complex processing of a large amount of data.
Negative Ion Formation in SiO<sub>2</sub> Etching Using a Pulsed Inductively Coupled Plasma (1998)

The formation of negative ions in conjunction with their effect on SiO 2 etching characteristics has been investigated within a CF 4 /Ar pulsed-power inductively coupled plasma. Electron energy distribution function in the pulsed plasma shows a narrow distribution compared with the CW mode. The average electron energy and electron density decrease greatly with decreasing duty ratio, which indicates that the high-energy electrons can be cooled effectively during afterglow time. By means of threshold ionization mass spectrometry, radical densities including CF x ( x =1 to 3) and F are measured as a function of duty ratio and also correlated with the average energy and density of electrons. For negative ions, two major peaks, F - and CF 3 - , are formed predominantly through the electron attachment reactions during afterglow time. The possible mechanisms for the negative ion formation are proposed in the pulsed plasma. Additionally, the SiO 2 etch rate decreases nearly linearly with decreasing duty ratio and microtrenching is suppressed by the reduction of charge accumulation on the sidewalls in the pulsed plasma.
Effectiveness of an acellular synthetic matrix in the treatment of hard‐to‐heal leg ulcers (2013)

Hard-to-heal leg ulcers are a major cause of morbidity in the elderly population. Despite improvements in wound care, some wounds will not heal and they present a significant challenge for patients and health care providers. A multi-centre cohort study was conducted to evaluate the effectiveness and safety of a synthetic, extracellular matrix protein as an adjunct to standard care in the treatment of hard-to-heal venous or mixed leg ulcers. Primary effectiveness criteria were (i) reduction in wound size evaluated by percentage change in wound area and (ii) healing assessed by number of patients healed by end of the 12 week study. Pain reduction was assessed as a secondary effectiveness criteria using VAS. A total of 45 patients completed the study and no difference was observed between cohorts for treatment frequency. Healing was achieved in 35·6% and wound size decreased in 93·3% of patients. Median wound area percentage reduction was 70·8%. Over 50% of patients reported pain on first visit and 87·0% of these reported no pain at the end of the study. Median time to first reporting of no pain was 14 days after treatment initiation. The authors consider the extracellular synthetic matrix protein an effective and safe adjunct to standard care in the treatment of hard-to-heal leg ulcers.
The effectiveness of N-acetylcysteine for an adult case of pulmonary alveolar proteinosis: A case report (2019)

Persistent oral N-acetylcysteine may be an alternative treatment option for secondary PAP.
Balancing the interconnect topology for arrays of processors between cost and power (2003)

High performance SoC requires nonblocking interconnections between an array of processors built on one chip. With the advent of deep sub-micron technologies, switches are becoming much cheaper while wires are still expensive. Therefore, optimization efforts should focus on the wire resources. In this paper, we devise air objective function to balance the interconnect topology between routing area and power dissipation. Based on the objective function, we find the best one-dimensional and two-dimensional nonblocking interconnect architectures. Furthermore, we define a derivative benefit and devise a strategy for improving the performance of hierarchical nonblocking interconnect architectures and derive optimized results.
Intussusception Among Recipients of Rotavirus Vaccine: Reports to the Vaccine Adverse Event Reporting System (2001)

Using a passive surveillance system for vaccine adverse events, we observed at least a fourfold increase over the expected number of intussusception cases occurring within 1 week of receipt of rotavirus vaccine. Other studies were initiated to further define the relationship between rotavirus vaccine and intussusception. In light of these and other data, the rotavirus vaccine manufacturer voluntarily removed its product from the market, and the recommendation for routine use of rotavirus vaccine among US infants has been withdrawn.
Stretch-inducible Expression of the Angiogenic Factor CCN1 in Vascular Smooth Muscle Cells Is Mediated by Egr-1 (2004)

CCN1 is an angiogenic factor that promotes cell adhesion, proliferation, and differentiation. CCN1-deficient mice suffer embryonic death because of vascular defects, demonstrating that CCN1 is required for vessel development. Because mechanical stretch may act as a trigger for vessel development, we investigated the impact of mechanical stretch on the regulatory mechanism of CCN1 expression. Mechanical stretch rapidly enhances CCN1 expression and release in vascular smooth muscle cells (VSMC) in vitro and CCN1 expression in murine aortic segments in vivo. Transfection experiments of VSMC with deletion constructs of the CCN1 promoter revealed the regulatory region responsible for the stretch-induced CCN1 expression in the approximately 200-bp promoter region upstream of the TATA-box containing potential binding sites for early growth response-1 (Egr-1), nuclear factor of activated T-cells and cAMP response element binding protein. Decoy oligonucleotides to Egr-1, but not to nuclear factor of activated T-cells or cAMP response element binding protein, abolished the stretch-induced transcription of CCN1. In addition, mutagenesis of the Egr-1 binding site within the CCN1 promoter completely blunted the stretch-induced activation of the promoter. Furthermore, mechanical stretch induced the expression and DNA-binding activity of Egr-1 in VSMC as demonstrated by Western blot and electromobility shift assay. Moreover, a pressure overload-dependent de novo synthesis of Egr-1 was observed after aortic banding. These findings indicate that mechanical stretch leads to enhanced expression of CCN1 via the mechanosensitive transcription factor Egr-1, suggesting a central role for mechanical stretch in the regulation of CCN1-dependent pro-angiogenic potency.
Instruction2vec: Efficient Preprocessor of Assembly Code to Detect Software Weakness with CNN (2019)

Potential software weakness, which can lead to exploitable security vulnerabilities, continues to pose a risk to computer systems. According to Common Vulnerability and Exposures, 14,714 vulnerabilities were reported in 2017, more than twice the number reported in 2016. Automated vulnerability detection was recommended to efficiently detect vulnerabilities. Among detection techniques, static binary analysis detects software weakness based on existing patterns. In addition, it is based on existing patterns or rules, making it difficult to add and patch new rules whenever an unknown vulnerability is encountered. To overcome this limitation, we propose a new method—Instruction2vec—an improved static binary analysis technique using machine. Our framework consists of two steps: (1) it models assembly code efficiently using Instruction2vec, based on Word2vec; and (2) it learns the features of software weakness code using the feature extraction of Text-CNN without creating patterns or rules and detects new software weakness. We compared the preprocessing performance of three frameworks—Instruction2vec, Word2vec, and Binary2img—to assess the efficiency of Instruction2vec. We used the Juliet Test Suite, particularly the part related to Common Weakness Enumeration(CWE)-121, for training and Securely Taking On New Executable Software of Uncertain Provenance (STONESOUP) for testing. Experimental results show that the proposed scheme can detect software vulnerabilities with an accuracy of 91% of the assembly code.
High efficiency wavelength conversion of 10 Gb/s data in silicon waveguides (2006)

Efficient wavelength conversion via four-wave-mixing in silicon-on-isolator p-i-n waveguides has been realized. By reverse biasing the p-i-n diode structure formed along the silicon rib waveguide, the nonlinear absorption due to two photon absorption induced free carrier absorption is significantly reduced, and a wavelength conversion efficiency of -8.5 dB has been achieved in an 8 cm long waveguide at a pump intensity of 40 MW/cm2. A high-speed pseudo-random bit sequence data at 10 Gb/s rate is converted to a new wavelength channel in the C-band with clear open eye diagram and no waveform distortion. Conversion efficiency as functions of pump power, wavelength detuning, and bias voltages, have been investigated. For shorter waveguides of 1.6 cm long, a conversion bandwidth of > 30 nm was achieved.
Block truncation coding with entropy coding (1995)

Block truncation coding (BTC) is a simple and fast image compression algorithm which achieves a constant bit rate of 2.0 bits per pixel. The method is however suboptimal. We propose a modification of BTC in which the compression ratio is improved by coding the quantization data and the bit plane by arithmetic coding with an adaptive modelling scheme. The results compare favorable with other BTC variants. The bit rate for test image Lena is 1.53 bits per pixel with a mean square error of 16.51.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Temperature-stable voltage reference based on different threshold voltages of NMOS transistors (2009)

A temperature-stable voltage reference based on threshold voltages of enhancement and depletion NMOS transistors has been presented and implemented with a 0.5 µm DPDM CMOS technology. The problem of a fixed voltage reference value is avoided by different parameter design. A significant reduce of temperature dependence of mobility is also achieved. The chip's area is 0.014 mm2. The test results show that the operation supply voltage is from 2 to 5 V, the maximum supply current is 8.24 µA, and the average reference voltage is 765 mV with an average line regulation of ±0.187%/V. A typical temperature coefficient of 39.2 ppm/°C for a temperature range of 0–100°C is obtained. The power-supply rejection ratio, without any filtering capacitors, is −46 dB at 100 Hz and −32 dB at 1 MHz for the smallest supply voltage.
Endogenously Generated Active Oxygen Species and Cellular Glutathione Levels in Relation to BHK-21 Cell Proliferation (1994)

In BHK-21 cells (baby hamster kidney fibroblasts) cellularly generated active oxygen species such as hydrogen peroxide and superoxide appear to be important growth regulatory signals as judged from the growth inhibitory effects of catalase, superoxide dismutase and superoxide dismutase mimics. These active oxygen species may contribute a novel redox system of regulatory control superimposed upon established growth signal pathways. This may be achieved by direct oxidative modification of cell regulatory proteins such as transcription factors or protein kinases or indirectly through, for example alterations in levels of glutathione (GSH). This latter possibility is suggested from observations that catalase, or superoxide dismutase treatment of BHK-21 cells brings about increased cellular levels of GSH. However during the normal growth phase cellular levels of GSH actually decline although this effect can be partly reversed by N-acetylcysteine and by mercaptosuccinate which also impair proliferation of these cells.
Increased bone mass with pamidronate treatment in rheumatoid arthritis. Results of a three‐year randomized, double‐blind trial (1996)

The present study provides the first evidence that long-term treatment with an orally administered bisphosphonate overcomes bone loss and increases bone mass when compared with placebo. This finding may have significance with regard to the treatment of patients with RA.
Prospective Study of Hemostatic Factors and Incidence of Coronary Heart Disease (1997)

Background Although hemostatic factors contribute to acute coronary syndromes and atherogenesis, few studies have prospectively evaluated the association between multiple hemostatic factors and coronary heart disease incidence. Methods and Results The Atherosclerosis Risk in Communities Study recruited 14 477 adults from 45 to 64 years of age who were initially free of coronary heart disease. Coronary disease risk factors and several plasma hemostatic factors were measured, and incidence of coronary heart disease was ascertained during an average follow-up of 5.2 years. Age-, race-, and field center–adjusted relative risks of coronary heart disease were significantly elevated ( P ≤.05) per higher value of fibrinogen (relative risk: men, 1.76; women, 1.54), white blood cell count (men, 1.68; women, 2.23), factor VIII coagulant activity (women, 1.25), and von Willebrand factor antigen (men, 1.20; women, 1.18). Adjustment for other risk factors attenuated these associations for fibrinogen (adjusted relative risk: men, 1.48; women, 1.21), and it eliminated the white blood cell count, factor VIII, and von Willebrand factor associations, consistent with the other risk factors either confounding or partly operating through their effects on the hemostatic variables. Adjusted standardized relative risks of total mortality, ranging from 1.13 to 1.37, were also elevated ( P <.05) in relation to these four factors. There was no association of coronary disease incidence with factor VII, protein C, antithrombin III, or platelet count. Conclusions Elevated levels of fibrinogen, white blood cell count, factor VIII, and von Willebrand factor are risk factors and may play causative roles in coronary heart disease. However, their measurement in healthy adults appears to add little to prediction of coronary events beyond that of more established risk factors.
Comparison of Four Molecular <i>In Vitro</i> Diagnostic Assays for the Detection of SARS-CoV-2 in Nasopharyngeal Specimens (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel human coronavirus that causes coronavirus disease 2019 (COVID-19), was first discovered in December 2019 as the cause of an outbreak of pneumonia in the city of Wuhan, Hubei province, China. The clinical presentation of COVID-19 is fairly nonspecific, and symptoms overlap those of other seasonal respiratory infections concurrently circulating in the population. Furthermore, it is estimated that up to 80% of infected individuals experience mild symptoms or are asymptomatic, confounding efforts to reliably diagnose COVID-19 empirically. To support infection control measures, there is an urgent need for rapid and accurate molecular diagnostics to identify COVID-19-positive patients. In the present study, we evaluated the analytical sensitivity and clinical performance of the following four SARS-CoV-2 molecular diagnostic assays granted emergency use authorization by the FDA using nasopharyngeal swabs from symptomatic patients: the New York SARS-CoV-2 Real-time Reverse Transcriptase (RT)-PCR Diagnostic Panel (modified CDC) assay, the Simplexa COVID-19 Direct (Diasorin Molecular) assay, GenMark ePlex SARS-CoV-2 (GenMark) assay, and the Hologic Panther Fusion SARS-CoV-2 (Hologic) assay. This information is crucial for both laboratories and clinical teams as decisions on which testing platform to implement are made.
Evaluation of genome coverage and fidelity of multiple displacement amplification from single cells by SNP array (2009)

The scarce amount of DNA contained in a single cell is a limiting factor for clinical application of preimplantation genetic diagnosis mainly due to the risk of misdiagnosis caused by allele dropout and the difficulty in obtaining copy number variations in all 23 pairs of chromosomes. Multiple displacement amplification (MDA) has been reported to generate large quantity of products from small amount of templates. Here, we evaluated the fidelity of whole-genome amplification MDA from single or a few cells and determined the accuracy of chromosome copy number assessment on these MDA products using an Affymetrix 10K 2.0 SNP Mapping Array. An average coverage rate (86.2%) from single cells was obtained and the rates increased significantly when five or more cells were used as templates. Higher concordance for chromosome copy number from single cells could be achieved when the MDA amplified product was used as reference (93.1%) than when gDNA used as reference (82.8%). The present study indicates that satisfactory genome coverage can be obtained from single-cell MDA which may be used for studies where only a minute amount of genetic materials is available. Clinically, MDA coupled with SNP mapping array may provide a reliable and accurate method for chromosome copy number analysis and most likely for the detection of single-gene disorders as well.
Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA (2009)

The matrix (M1) protein of influenza A virus is a conserved multifunctional protein that plays essential roles in regulating the viral life cycle. This study demonstrated that M1 is able to interact with complement C1qA and plays an important inhibitory function in the classical complement pathway. The N-terminal domain of M1 protein was required for its binding to the globular region of C1qA. As a consequence, M1 blocked the interaction between C1qA and heat-aggregated IgG in vitro and inhibited haemolysis. It was shown that M1 protein prevented the complement-mediated neutralization of influenza virus in vitro. In addition, studies on mice indicated that the administration of M1 could promote a higher virus propagation rate in lung and shortened survival of mice infected with the virus. Taken together, these results suggest strongly that the M1 protein plays a critical role in protecting influenza virus from the host innate immune system.
A high level synthesis tool for systolic designs (2003)

The authors present DECOMPOSER, a high-level synthesis tool for automating the design of systolic systems. DECOMPOSER takes as inputs a hierarchical description of the computation to be performed and some hint as to how it is to be performed. The computation description is in the form of a parameterized DAG (directed acyclic graph) so that different problem sizes can be handled. The hit is in the form of marking information for that DAG. DECOMPOSER produces a detailed report on the hardware requirements for the specified computation. In particular, the structure of each computation node, how the computation nodes are connected, and the input and output sequences are given. The information is passed to other tools in the tool set so that ultimately a layout description file in suitable format (e.g. CIF) can be generated for the architecture performing the computation derived by DECOMPOSER.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High quality In0.48Ga0.52P grown by gas source molecular beam epitaxy (1992)

We report the growth of high quality In0.48Ga0.52P lattice matched to GaAs substrates by gas source molecular beam epitaxy. A full width at half-maximum (FWHM) of the (004) double crystal x-ray diffraction peak as small as 19 arc sec was measured from a 1.8 μm thick epilayer. Such line width is the narrowest reported thus far for any growth technique. Room temperature cathodoluminescence shows a band gap of ∼1.92 eV and the narrowest measured FWHM is 29 meV. Electron mobilities as high as 3200 and 25 700 cm2/V s have been obtained from Hall measurements at 300 and 77 K, respectively, which are comparable with the highest values ever reported.