gebhart/patrepeval huggingface dataset:
Parvifloracin and parviflorin: cytotoxic bistetrahydrofuran acetogenins with 35 carbons from <i>Asimina</i> <i>parviflora</i> (Annonaceae) (1994)

Using lethality to brine shrimp, activity-directed fractionation of extracts of Asimina parviflora (Michx.) Dunal. (Annonaceae) has led to the isolation of two new and four known acetogenins (1–6). Compound 1, parvifloracin, is the first nonadjacent bistetrahydrofuran acetogenin with 35 carbons. Compound 2, parviflorin, is an unusual adjacent bistetrahydrofuran acetogenin with 35 carbons. Bullatacin (3), molvizarin (4), annonacin (5), and goniothalamicin (6) are also reported for the first time from this plant. Brine shrimp lethality test data and comparative cytotoxicities of 1–6 against three human solid tumor cell lines are presented.
CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells (2008)

The adoptive transfer of regulatory Foxp3(+) T (Treg) cells has been shown in various animal models to prevent inflammatory immune and autoimmune diseases. Translation into therapeutic applications, however, is hindered by the lack of suitable techniques and markers. CD25, commonly used to isolate Treg cells from mice, has only limited value in humans as it is also present on proinflammatory CD4(+) effector cells. Here we show that clean populations of human Foxp3(+) Treg cells can be obtained with antibodies directed against CD49d. The marker is present on proinflammatory peripheral blood mononuclear cells but is absent on immune-suppressive Treg cells. Depletion with alpha-CD49d removes contaminating interferon-gamma (IFN-gamma)- and interleukin-17 (IL-17)-secreting cells from Treg preparations of CD4(+)CD25(high) cells. More importantly, in combination with alpha-CD127 it allows the isolation of "untouched" Foxp3(+) Treg (ie, cells that have not been targeted by an antibody during purification). The removal of CD49d(+)/CD127(+) cells leaves a population of Foxp3(+) Treg virtually free of contaminating CD25(+) effector cells. The cells can be expanded in vitro and are effective suppressors both in vitro and in vivo. Thus, CD49d provides access to highly pure populations of untouched Foxp3(+) Treg cells conferring maximal safety for future clinical applications.
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer (2019)

Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC).
Disease stage‐specific G protein‐coupled receptor expression in clinical disorders: Chronic lymphocytic leukemia as a model (2012)

G protein‐coupled receptors (GPCRs) are attractive targets in disease since they are expressed on the plasma membrane and show tissue‐specific expression. A clinical problem for many heterogeneous diseases, such as Chronic lymphocytic leukemia (CLL), is the lack of markers that can predict prognosis. CLL, which is characterized by the accumulation of B‐cells, is classified as aggressive, which requires immediate treatment, or indolent, which does not require treatment. We hypothesized that patterns of GPCR expression are disease stage‐specific and used CLL as a model to test if such patterns can identify biomarkers and therapeutic targets. Using a TaqMan® GPCR array we found that normal B‐cells (n=10) express greater than 200 GPCRs (74 orphan receptors), indolent CLL cells (n=10) express greater than 170 GPCRs (74 orphan GPCRs) and aggressive CLL cells (n=10) express greater than 117 GPCRs (51 orphan GPCRs). Numerous GPCRs were uniquely expressed or altered in CLL and expression differed in the 2 stages of CLL. Expression of vasoactive intestinal polypeptide receptor 1 (VIPR1), a Gs‐coupled GPCR, increased >700‐fold in aggressive CLL compared to indolent, and VIP (1 μM, 48h) induced apoptosis of CLL cells (P<0.05, n=3). Thus, expression of particular GPCRs can provide stage‐specific markers and identify novel targets for the treatment of CLL or other heterogeneous diseases. Funded by NIH.
EBP1 inhibits translation of androgen receptor mRNA in castration resistant prostate cancer cells. (2011)

These studies suggest that one pathway of EBP1 down-regulation of AR levels may be lost in CRPC.
Direct Deposition of Electronic Materials with Thermal DPN (2005)

In recent years there has been a significant effort to improve or augment lithographic techniques for electronic device fabrication. Although improvements in ultimate resolution have been a central goal, other goals have also been pursued that may be important avenues to advance device fabrication. These alternate objectives include reduction of toxic by-products (“green chemistry”), integration of disparate materials into a single structure (e.g., organic and inorganic), and production or prototyping of low numbers of integrated circuits at relatively low unit cost. Progress towards all these goals is found in a new lithographic technique, thermal Dip Pen Nanolithography (tDPN). In tDPN (Figure 1), an atomic force microscope (AFM) cantilever is custom fabricated to include a heater directly above the tip. The tip is then coated with an “ink” that is solid at room temperature but that can be melted by the integrated heater. When the ink is melted, it flows onto the surface and solidifies, thereby allowing arbitrary patterns to be written.
X-ray Crystal Structures of 70 <i>S</i> Ribosome Functional Complexes (1999)

Structures of 70S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstrom resolution. Many details of the interactions between tRNA and the ribosome, and of the packing arrangements of ribosomal RNA (rRNA) helices in and between the ribosomal subunits, can be seen. Numerous contacts are made between the 30S subunit and the P-tRNA anticodon stem-loop; in contrast, the anticodon region of A-tRNA is much more exposed. A complex network of molecular interactions suggestive of a functional relay is centered around the long penultimate stem of 16S rRNA at the subunit interface, including interactions involving the "switch" helix and decoding site of 16S rRNA, and RNA bridges from the 50S subunit.
Trace Contaminant Sorption through Polymeric Ligand Exchange (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrace Contaminant Sorption through Polymeric Ligand ExchangeDongye Zhao, Arup K. Sengupta, and Yuewei ZhuCite this: Ind. Eng. Chem. Res. 1995, 34, 8, 2676–2684Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/ie00047a017https://doi.org/10.1021/ie00047a017research-articleACS PublicationsRequest reuse permissionsArticle Views245Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel Styrylpyridines as Probes for SPECT Imaging of Amyloid Plaques (2007)

We report a series of radioiodinated styrylpyridines as single photon emission computed tomography probes for imaging Abeta plaques in the brain of patients with Alzheimer's disease (AD). In vitro binding showed that all of the styrylpyridines displayed very good binding affinities in postmortem AD brain homogenates (Ki = 3.6 to 15.5 nM). No-carrier-added samples of 13a, 13b, 16a, 16b, and 16e (radioiodinated with 125I) were successfully prepared. The in vivo biodistribution in normal mice, at 2 min after injection, showed excellent initial brain penetrations (4.03, 6.22, 5.43, and 8.04% dose/g for [125I]13a, 13b, 16a, and 16b, respectively). Furthermore, in vitro autoradiography of AD brain sections showed that the high binding signal was specifically due to the presence of Abeta plaques. Taken together, these results strongly suggest that these styrylpyridines are useful for imaging Abeta plaques in the living human brain.
Molecularly Tunable Polyanions for Single-Ion Conductors and Poly(solvate ionic liquids) (2021)

Polymer electrolytes (PEs) have attracted tremendous research interest for their potential to offer improved safety and energy capacity in next-generation battery technologies. Among the different classes of PEs, single-ion conductors (SICs) are particularly interesting due to their high transference numbers. Nevertheless, a detailed understanding of how molecular structure impacts the properties of SIC-PEs is absent, limiting the ability to design improved materials. Here, we present the synthesis and characterization of a new class (seven examples provided) of polyanions featuring fluorinated aryl sulfonimide tagged (FAST) anions as side chains. These “polyFAST” salts are shown to outperform the widely used poly[(4-styrenesulfonyl) (trifluoromethanesulfonyl)imide] due to their strongly electron-withdrawing side chains and enhanced distance between anionic sites, providing higher electronic conductivities at all salt concentrations and in some cases superior electrochemical oxidative stability. Moreover, they provide a platform for discovery of fundamental relationships between macromolecular composition, as programmed through monomer structure, and SIC-PE bulk properties. Finally, we leverage the electron-deficient nature of polyFAST salts to demonstrate a new poly(solvate ionic liquid) (polySIL) concept that offers a promising pathway toward high-performance PEO-free SIC-PEs.
Clinical Experience With IV Angiotensin II Administration: A Systematic Review of Safety (2017)

Adverse events associated with angiotensin II were infrequent; however, exacerbation of asthma and congestive heart failure and one fatal cerebral hemorrhage were reported. This systematic review supports the notion that angiotensin II has an acceptable safety profile for use in humans.
Role of FGF9 and FGF Receptor 3 in Osteochondroma Formation (2001)

Osteochondromas are chondro-osseous protuberances that occur in metaphyses of long bones. The cartilaginous cap is assumed to be responsible for the growth of the lesions during childhood and adolescence, but mitotic figures are rarely seen in the cap. Therefore, another cell population, probably mesenchymal cells, is responsible for proliferation and growth. Residual mesenchymal cells capable of rapid proliferation are difficult to detect due to lack of specific histologic features. Two specific markers for mesenchymal cells, FGF receptor 3 (FGFR3) and collagen type IIa, have been described. Osteochondroma mesenchymal cells are found in the soft tissues overlying the cartilage cap. The surrounding areas of typical cartilage are negative for both mesenchymal cell associated antigens. The soft tissues overlying the cartilage do not have cartilaginous features. The undifferentiated cells overlying the exostosis yield in culture a rapidly proliferating homogenous population of fibroblast-like cells. Expression at the mRNA level of FGF9, FGFR3, and collagen type IIa is found in these cells, but not in skin fibroblasts from afflicted or healthy individuals. Exogenous administration of TGFbeta1 to cultures of hereditary multiple exostosis eliminates FGF9 expression. These results indicate fibrous regions contain the mesenchymal cells responsible for osteochondroma growth.
Size Effects on Carbon-Free LiFePO[sub 4] Powders (2006)

C-free crystalline powders were prepared by a synthesis method based on direct precipitation under atmospheric pressure. The particle size distribution is extremely narrow, centered on ca. . A soft thermal treatment, typically at for under slight reducing conditions was shown to be necessary to obtain satisfactory electrochemical deinsertion/insertion properties. This thermal treatment does not lead to grain growth or sintering of the particles, and does not alter the surface of the particles. The electrochemical performances of the powders obtained by this synthesis method are excellent, in terms of specific capacity ( at 5C-rate) as well as in terms of cyclability (no significant capacity fade after more than 400 cycles), without the need of carbon coating.
Polarization Effects on Thermally Stable Latency in Hollow-Core Photonic Bandgap Fibres (2019)

Hollow-Core fibers were recently demonstrated to have propagation time through them completely insensitive to changes in temperature. Here, we consider polarization dependent behaviour of these fibers and show how it can alter the fibre design.
Weak Epitaxy Growth of Phthalocyanine on 2,5-Bis(4-1,1′:4′,1′′-terphenyl)-thiophene and the Effect of Phase State of Inducing Layer (2010)

The growth of ultrathin films of 2,5-bis(4-1,1':4',1''-terphenyl)-thiophene (3PT) and weak epitaxy growth (WEG) behavior of phthalocyanines (H(2)Pc and ZnPc) on 3PT ultrathin films were investigated by atomic force microscopy, X-ray diffraction (XRD), and select area electron diffraction (SAED). Domain size of the monolayer films can reach 10 μm at the substrate temperature of 190 °C. The second layer films begin to show Volmer-Weber growth mode. This growth mode transformed without a concomitant phase transition. The XRD and SAED measurements indicate the monolayer and double-layer films of 3PT have identical in-plane and out-of-plane structure. The epitaxial ZnPc films have a similar orientation or intertexture shape utilizing 3PT monolayer and double-layer films as the inducing layer. By comparison with utilizing para-sexiphenyl (p-6P) as the inducing layer, the morphology with clear borderline of epitaxial films with different orientations on joint of neighboring 3PT monolayer domains disclosed that the 3PT monolayer films have characteristics of crystal. Meanwhile the distinguishing effects of inducing layer phase state on morphology of epitaxial films were shown, respectively.
Memory-efficient parallel tensor decompositions (2017)

Tensor decompositions are a powerful technique for enabling comprehensive and complete analysis of real-world data. Data analysis through tensor decompositions involves intensive computations over large-scale irregular sparse data. Optimizing the execution of such data intensive computations is key to reducing the time-to-solution (or response time) in real-world data analysis applications. As high-performance computing (HPC) systems are increasingly used for data analysis applications, it is becoming increasingly important to optimize sparse tensor computations and execute them efficiently on modern and advanced HPC systems. In addition to utilizing the large processing capability of HPC systems, it is crucial to improve memory performance (memory usage, communication, synchronization, memory reuse, and data locality) in HPC systems. In this paper, we present multiple optimizations that are targeted towards faster and memory-efficient execution of large-scale tensor analysis on HPC systems. We demonstrate that our techniques achieve reduction in memory usage and execution time of tensor decomposition methods when they are applied on multiple datasets of varied size and structure from different application domains. We achieve up to 11× reduction in memory usage and up to 7× improvement in performance. More importantly, we enable the application of large tensor decompositions on some important datasets on a multi-core system that would not have been feasible without our optimization.
Multi-Frame Self-Supervised Depth with Transformers (2022)

Multi-frame depth estimation improves over single-frame approaches by also leveraging geometric relationships between images via feature matching, in addition to learning appearance-based features. In this paper we revisit feature matching for self-supervised monocular depth estimation, and propose a novel transformer architecture for cost volume generation. We use depth-discretized epipolar sampling to select matching candidates, and refine predictions through a series of self- and cross-attention layers. These layers sharpen the matching probability between pixel features, improving over standard similarity metrics prone to ambiguities and local minima. The refined cost volume is decoded into depth estimates, and the whole pipeline is trained end-to-end from videos using only a photometric objective. Experiments on the KITTI and DDAD datasets show that our DepthFormer architecture establishes a new state of the art in self-supervised monocular depth estimation, and is even competitive with highly specialized supervised single-frame architectures. We also show that our learned cross-attention network yields representations transferable across datasets, increasing the effectiveness of pre-training strategies. Project page: https://sites.google.com/tri.global/depthformer.
Stem cell factor enhances interleukin-3 dependent induction of 68-kD calmodulin-binding protein and thymidine kinase activity in NFS-60 cells (1996)

Stem cell factor (SCF) is known to act synergistically with other hematopoietic factors in increasing the colony formation of hematopoietic progenitor cells. We have shown that interleukin-3 (IL-3)-dependent proliferation of NFS-60 cells is associated with the induction of a specific calmodulin-binding protein of about 68 kD (CaM-BP68). To evaluate the relationship between proliferative stimulation and the induction of CaM-BP68 by cytokines, we examined whether the increased proliferative potential of NFS-60 cells in response to SCF is reflected in an increased induction of the CaM-BP68. We observed that SCF alone has a limited effect on proliferative stimulation and on the induction of CaM-BP68 in factor-deprived NFS-60 cells. However, when combined with IL-3, granulocyte colony-stimulating factor (G-CSF), or IL-6, it caused a significant increase in cytokine-dependent proliferative stimulation, as well as in the induction of CaM-BP68. Furthermore, an increase in IL-3-dependent induction of CaM-BP68 in the presence of SCF coincided with a corresponding increase in thymidine kinase activity, whose expression is linked to G1/S transition of the cells. At low concentrations SCF caused a synergistic increase in IL-3-dependent induction of both CaM-BP68 and thymidine kinase activity. In contrast to the changes in CaM-BP68 and thymidine kinase activity, no significant changes in DNA polymerase alpha were observed in factor-deprived NFS-60 cells in response to IL-3 and/or SCF. These observations suggest an increased expression of CaM-BP68 and thymidine kinase are associated with the synergistic effect of SCF on factor-dependent proliferation of hematopoietic progenitor cells.
Use of Biodiesel as an Additive in Thermal Recovery of Heavy Oil and Bitumen (2010)

Summary Bitumen extraction in oil sands-ore water slurry systems was studied by using lipids and lipid derivatives such as biodiesel (BD) as surfactant additive to promote bitumen recovery efficiency. Performance of BDs (i.e., canola and tall oil, a by-product of pulp mills using the bleached Kraft process) fatty acids methyl ester and food-grade fatty acids monoglycerides were evaluated as surfactant additives. Experimental findings suggest that BDs such as fatty acids methyl esters could also be used as surfactant additives to increase the efficiency of bitumen recovery in thermal in-situ processes such as steam assisted gravity drainage (SAGD) and cyclic steam stimulation (CSS) processes. The required dosage for the surfactant additive is about 0.1% of bitumen by mass. Also, interfacial tension measurements between bitumen and process water (YB,W) and BD and process water (YBD,W) support the surfactant behavior of BD.
Chemically Activatable Viral Capsid Functionalized for Cancer Targeting (2016)

These results demonstrate the production of a theranostic capsule suitable for cancer diagnostics and therapeutics based on surface modification of a highly stable virus-like nanoparticle.
AVIO: Detecting Atomicity Violations via Access-Interleaving Invariants (2007)

This article proposes an innovative concurrent-program invariant that captures programmers' atomicity assumptions. It describes a tool with two implementations, one in software and the other using hardware support that can automatically extract such invariants and detect atomicity violation bugs
A type-2 fuzzy based system for handling the uncertainties in group decisions for ranking job applicants within Human Resources systems (2008)

Ranking applicants for a given job is one of the most important processes for Human Resources (HR) systems. The ranking of job applicants involves two main processes which are the specification of the requirements criteria for a given job (experience, skills, etc) and the matching between the applicantspsila profiles and the job requirements. There is currently a strong move towards automating these two processes to generate an applicantspsila ranking system that gives consistent and fair results. However there is a high level of uncertainty involved in these two processes as they involve the input of several experts. These experts will have different opinions, expectations the interpretations for the requirements specification as well as for the applicants matching and ranking. This paper presents a novel approach for ranking job applicants by employing type-2 fuzzy sets for handling the uncertainties in group decisions in a panel of experts. Hence the presented system will enable automating the processes of requirements specification and applicants matching/ranking. We have performed real world experiments in the care domain where our system handled the uncertainties and produced ranking decisions that were consistent with those of the human experts. To the authorspsila knowledge, this will be the first type-2 based commercial software system.
Selective conversion of synthesis gas into C2-oxygenated products using mixed-metal homogeneous catalysts (1986)

A feature which is a key to any wider utilization of chemistry based on synthesis gas is an understanding of, and more particularly, an ability to control, those factors which determine the selectivity of the C/sub 1/ to C/sub 2/ transformation during the hydrogenation of carbon monoxide. With the exception of the rhodium-catalyzed conversion of carbon monoxide and hydrogen into ethylene glycol and methanol, in which molar ethylene glycol/methanol selectivities of ca 2/1 may be achieved, other catalyst systems containing metals such as cobalt or ruthenium exhibit only poor selectivities to ethylene glycol. The initial studies in this area were based on the reasoning that, since the reduction of carbon monoxide to C/sub 2/ products is a complex, multi-step process, the use of appropriate combinations of metals could generate synergistic effects which might prove more effective (in terms of both catalytic activity and selectivity) than simply the sum of the individual metal components. In particular, the concept of the combination of a good hydrogenation catalyst with a good carbonylation, or ''CO insertion'', catalyst seemed particularly germane. As a result of this approach the authors discovered an unprecedented example of the effect of catalyst promoters, particularly in the enhancement of C/submore » 2//C/sub 1/ selectivity, and one which has led to the development of composite mixed-metal homogeneous catalyst systems for the conversion of CO/H/sub 2/ into C/sub 2/-oxygenate esters.« less