gebhart/patrepeval huggingface dataset:
Intramolecular excited-state proton transfer in 3-hydroxyflavone. Hydrogen-bonding solvent perturbations (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular excited-state proton transfer in 3-hydroxyflavone. Hydrogen-bonding solvent perturbationsDale McMorrow and Michael KashaCite this: J. Phys. Chem. 1984, 88, 11, 2235–2243Publication Date (Print):May 1, 1984Publication History Published online1 May 2002Published inissue 1 May 1984https://pubs.acs.org/doi/10.1021/j150655a012https://doi.org/10.1021/j150655a012research-articleACS PublicationsRequest reuse permissionsArticle Views1548Altmetric-Citations365LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
FAST TRANSPARENT FAILOVER FOR RELIABLE WEB SERVICE (2003)

Fault tolerance schemes can be used to increase the availability and reliability of network services. One aspect of such schemes is service failover --- the reconfiguration of available resources and restoration of state required to continue providing the service despite the loss of some of the resources and corruption of parts of the state. We have previously presented CoRAL, a fault tolerance scheme for Web service based on a redundant standby backup server and logging. The focus of this paper is the implementation and evaluation of client-transparent failover for this scheme. In the event of a primary server failure, active client connections failover to a spare where their processing continues seamlessly. If extra server resources are available, a new server can be reintegrated into the system to reestablish fault-tolerant operation. Our performance results indicate short failover times and low overhead during fault-free operation.
<title>Glazings with granular aerogel</title> (1994)

Double glazing units filled with granular aerogel open up new applications in the fields of daylighting systems and passive solar architecture. Silica aerogel has ideal characteristics for solar thermal applications. High transparency for solar radiation is combined with extremely low thermal conductivity. The chemical company BASF (D) is developing a granular form of aerogel, which will be introduced to the market in the near future. The application potential of this material in window systems was tested as part of a CEC-JOULE project in co-operation with four other industrial companies and two research institutes under the leadership of the Fraunhofer-Institut fur Solare Energiesysteme (FhG-ISE) in Freiburg. A typical u-value for a double glazed window with a 16 mm thick layer of granular aerogel is 1.0 W m<SUP>-2</SUP> K<SUP>-1</SUP>, the solar transmission for diffuse light is about 45%. Both parameters are variable over a wide range depending on the particle size distribution, thickness of the layer and choice of the filling gas. First window elements were tested in different applications. Realized installations are presented.
Thermal Conductivity of Simulated Soils by the Needle Probe Method for Energy Foundation Applications (2014)

Soil thermal conductivity is an important parameter in the design of ground source heat pump and energy foundation systems. A laboratory method for measuring the soil thermal conductivity is the needle probe method. Earlier, analysis of the needle probe test data has been simplistic, relying heavily on human judgment and rules of thumb. This article presents an alternative method of analyzing the needle probe data with the aid of MATLAB, which is a technical programming language and computing environment. Four agar–kaolin specimens of varying densities were prepared to resemble simple soils. These were tested using the needle probe for a range of heating times and heating powers, to see what effect these parameters would have on the results. The repeatability when keeping the heating time and heating power constant was within ±2%. When the heating time and heating power were varied, the variation in results from the average for a given specimen ranged from ±4% to +10%/–8%. This range is significantly higher than the repeatability. Possible reasons for this are discussed in this article.
Er:YAG laser-induced cavitation can activate irrigation for the removal of intraradicular biofilm (2022)

We investigated the biofilm removal effects of laser activated irrigation (LAI) using a pig model, focusing on the impact of the fiber tip position, and used a high-speed camera to observe the occurrence and positioning of the cavitation associated with laser irradiation. A total of 16 roots of deciduous mandibular second premolars from 4 pigs were used. After a pulpectomy, the canals were left open for 2 weeks and sealed for 4 weeks to induce intraradicular biofilm. Root canal irrigation was then performed with Er:YAG laser activation. The fiber tip was inserted at two different positions, i.e., into the root canal in the intracanal LAI group and into the pulp chamber in the coronal LAI group. Intracanal needle irrigation with saline or 5% NaOCl was utilized in the positive control and conventional needle irrigation (CNI) groups. SEM and qPCR were carried out to evaluate treatment efficacy. Statistical analysis was performed using ANOVA and a Tukey-Kramer post-hoc test for qPCR and with a Steel-Dwass test to compare the SEM scores, with α = 0.05. A high-speed camera was used to observe the generation of cavitation bubbles and the movement of the induced bubbles after laser irradiation. The intracanal and coronal LAI groups showed significantly lower amounts of bacteria than either the positive control or CNI groups. There was no significant difference found between the intracanal and coronal LAI groups. SEM images revealed opened dentinal tubules with the destruction of biofilm in both LAI groups. High-speed camera images demonstrated cavitation bubble production inside the root canal after a single pulse irradiation pulse. The generated bubbles moved throughout the entire internal multi-rooted tooth space. Coronal LAI can generate cavitation in the root canal with a simply placed fiber inside the pulp chamber, leading to effective biofilm removal. This method could thus contribute to the future development of endodontic treatments for refractory apical periodontitis caused by intraradicular biofilm.
MicroRNA-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1 (2014)

Hepatitis B virus surface antigen (HBsAg) is an important risk factor for hepatocellular carcinoma (HCC) and is downregulated during hepatocarcinogenesis. MicroRNAs (miRNAs) are frequently deregulated in HCC tissues. However, whether the deregulation of certain miRNAs in HCC has an impact on HBsAg expression remains unclear. We found here that microRNA-581 (miR-581), which is deregulated during hepatocarcinogenesis, promoted HBsAg expression. Additionally, miR-581 targeted Dicer and endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1) and repressed their expression. Although Dicer cannot process HBV transcripts, Dicer knockdown led to increased HBsAg secretion, most likely due to a reduction in the levels of Dicer-processed 7SL RNA fragments. Moreover, Dicer-processed 7SL RNA fragments partially inhibited the ability of miR-581 to stimulate HBsAg expression. Furthermore, we found that forced EDEM1 expression inhibited miR-581-mediated induction of HBsAg. Finally, transfection of miR-581 into HepG2.2.15 cells promoted cell proliferation and led to upregulation of genes involved in development, cell proliferation and protein secretion. Altogether, we conclude that miR-581 promotes HBsAg expression by targeting Dicer and EDEM1. Our findings suggest that downregulation of miR-581 during hepatocarcinogenesis may lead to a reduction in HBsAg expression and impede HCC development.
Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine (2012)

Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that erasure of CpG methylation (5mC) in PGCs occurs via conversion to 5-hydroxymethylcytosine (5hmC), driven by high levels of TET1 and TET2. Global conversion to 5hmC initiates asynchronously among PGCs at embryonic day (E) 9.5 to E10.5 and accounts for the unique process of imprint erasure. Mechanistically, 5hmC enrichment is followed by its protracted decline thereafter at a rate consistent with replication-coupled dilution. The conversion to 5hmC is an important component of parallel redundant systems that drive comprehensive reprogramming in PGCs. Nonetheless, we identify rare regulatory elements that escape systematic DNA demethylation in PGCs, providing a potential mechanistic basis for transgenerational epigenetic inheritance.
A new cavity configuration for cesium beam primary frequency standards (1988)

In the design of cesium beam frequency standards, the presence of distributed cavity phase shifts (associated with residual running waves) in the microwave cavity, due to the small losses in the cavity walls, can become a significant source of error. To minimize such errors in future standards, it has been proposed that the long Ramsey excitation structure be terminated with ring-shaped cavities in place of the conventional shorted waveguide. The ring cavity will minimize distributed cavity phase variations at the position of the atomic beam, provides only that the two sides of the ring and the T-junction feeding the ring are symmetric. A model is developed to investigate the validity of this concept in the presence of the small asymmetries that inevitably accompany the fabrication of such a cavity. The model, partially verified by laboratory tests, predicts that normal tolerances will allow the frequency shifts due to distributed cavity phase variations to be held at the 10/sup -15/ level for a beam tube with a Q of 10/sup 8/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
PCR assay to enhance global surveillance for SARS-CoV-2 variants of concern (2021)

With the emergence of SARS-CoV-2 variants that may increase transmissibility and/or cause escape from immune responses <sup>1-3</sup> , there is an urgent need for the targeted surveillance of circulating lineages. It was found that the B.1.1.7 (also 501Y.V1) variant first detected in the UK <sup>4,5</sup> could be serendipitously detected by the ThermoFisher TaqPath COVID-19 PCR assay because a key deletion in these viruses, spike Δ69-70, would cause a "spike gene target failure" (SGTF) result. However, a SGTF result is not definitive for B.1.1.7, and this assay cannot detect other variants of concern that lack spike Δ69-70, such as B.1.351 (also 501Y.V2) detected in South Africa <sup>6</sup> and P.1 (also 501Y.V3) recently detected in Brazil <sup>7</sup> . We identified a deletion in the ORF1a gene (ORF1a Δ3675-3677) in all three variants, which has not yet been widely detected in other SARS-CoV-2 lineages. Using ORF1a Δ3675-3677 as the primary target and spike Δ69-70 to differentiate, we designed and validated an open source PCR assay to detect SARS-CoV-2 variants of concern <sup>8</sup> . Our assay can be rapidly deployed in laboratories around the world to enhance surveillance for the local emergence spread of B.1.1.7, B.1.351, and P.1.
Debonding Properties of Residually Stressed Brittle‐Matrix Composites (1989)

Trends in interface debonding have been calculated during fiber pullout for composites with interfaces subject to residual tension. The debond behavior is shown to depend sensitively on the thermal expansion mismatch. The results are used as the basis for designing a pullout test specimen suitable for measuring the mixed‐mode fracture energy of bimaterial interfaces. The solutions also provide the background needed to assess the role of debonding in the toughening of ceramics by fibers.
The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies (2019)

There is growing interest in identifying predictive biomarkers for inhibitors of programmed cell death protein 1 receptor (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T-lymphocyte associated protein 4 (CTLA-4). Given the links between the stool microbiota, anticancer immunosurveillance, and general health, the composition of the gut microbiome has recently undergone investigation as a biomarker for immunotherapy. In this review, we highlight published results from preclinical and clinical studies to date supporting a relationship between the gut microbiome and antitumor efficacy of immune checkpoint inhibitors. Despite the promising and hypothesis-generating findings that have been produced in this arena to date, there remain some inconsistencies amongst present data that may need to be resolved to contribute to further development. Among these, a better understanding of the immunomodulatory function of the microbiome, standardization in sampling, sequencing techniques, and data analysis, and ensuring uniformity across various aspects of study design are warranted in conducting future prospective studies seeking to validate the gut microbiome as a potential biomarker of response to checkpoint blockade.
当前苏联教育的动向——评N.马休斯《苏联教育:斯大林以来的政策和机构》 (1984)

苏联的教育制度近30年来已走向现代化。从斯大林政权继承下来的教育制度已经从3,000万在校学生增加到1970年的近5,000万人。在赫鲁晓夫领导的10年(1953—1964)中,普及的4年制初等教育跃进到普及的8年制不完全的中等教育。在勃列日涅夫的20年期间完成了向普及的10年制中等
Bayesian Quantum Circuit (2018)

Parameterized quantum circuits (PQCs), as one of the most promising schemes to realize quantum machine learning algorithms on near-term quantum computers, have been designed to solve machine earning tasks with quantum advantages. In this paper, we explain why PQCs with different structures can achieve generative tasks in the discrete case from the perspective of probability estimation. Although different kinds of PQCs are proposed for generative tasks, the current methods often encounter the following three hurdles: (1) the mode contraction problem; (2) unexpected data are often generated with a high proportion; (3) target data cannot be sampled directly. For the purpose of tackling the above hurdles, we devise Bayesian quantum circuit (BQC) through introducing ancillary qubits to represent prior distributions. BQC advances both generative and semi-supervised quantum circuit learning tasks, where its effectiveness is validated by numerical simulations using the Rigetti Forest platform.
Heterogeneous cytogenetic abnormalities in small cell lung cancer cell lines. (1987)

Ten cell lines were established from different biopsies from nine patients with small cell lung cancer (SCLC). These were established from metastases in the marrow (7), breast (1), pleural fluid (1), and spinal cord (1) and had been in culture for periods varying from 1 to 11 months. All cell lines exhibited typical cytological features of SCLC, and produced neuron specific enolase. All lines examined (5) contained dense core granules and were tumorigenic when injected intracranially into nude mice. None of the six cell lines tested had an amplified oncogene (c-myc or n-myc) previously reported to be amplified in SCLC. Detailed chromosome analyses were undertaken and showed that a structural abnormality of chromosome 3(p11p23) was a frequent (6 of 10) but not invariable finding. Our study and one other indicate that there is not a unique chromosome abnormality present in all cases of SCLC, although loss of chromosome 13 and structural abnormalities of chromosome 3 were frequently found. A feature of these SCLC cell lines established from metastatic deposits was the complexity of the karyotypes due to numerical and structural chromosomal abnormalities.
Simulated Effects of YY-Male Stocking and Manual Suppression for Eradicating Nonnative Brook Trout Populations (2017)

Abstract Eradication of nonnative Brook Trout Salvelinus fontinalis populations is difficult to achieve with standard techniques, such as electrofishing removal or piscicides; new approaches are needed. A novel concept is to stock “supermale” hatchery fish with wild conspecifics. Supermales (MYY) have two Y-chromosomes, resulting in offspring that are all males; over time, successful supermale reproduction could eradicate the wild population. We constructed an age-structured stochastic model to investigate the effects of manually suppressing wild fish and stocking MYY fingerlings on the long-term viability of hypothetical nonnative Brook Trout populations. In streams, an annual stocking rate of supermales equivalent to 50% of wild age-0 Brook Trout density combined with an annual selective suppression rate equivalent to 50% of wild Brook Trout density resulted in a time to extirpation of only 2–4 years if supermale fitness was equivalent to wild male fitness. However, time to extirpation in streams was 5–15 years if supermale fitness was 80% lower than wild male fitness. In alpine lakes, higher supermale stocking rates and nonselective gillnetting were required to eradicate Brook Trout populations. If supermales were assumed to be as fit as wild males, however, any supermale stocking rate greater than 49% in alpine lakes or 60% in streams achieved eradication in 10 years or less, regardless of the suppression rate. Because manual suppression and the stocking of MYY fingerlings can readily be conducted at the levels assumed in our simulations, use of such an integrated pest management (IPM) approach could extirpate undesirable Brook Trout populations within reasonably short periods of time. Given the recent successful development of an MYY Brook Trout broodstock capable of producing large numbers of MYY fingerlings and given the positive results of the present simulations for both streams and alpine lakes, field testing of MYY stocking is warranted within an IPM program that includes manual suppression for eradicating undesirable Brook Trout populations. Received October 14, 2016; accepted June 10, 2017 Published online August 22, 2017
A Semiconserved Residue Inhibits Complex Formation by Stabilizing Interactions in the Free State of a Theophylline-Binding RNA (1998)

The theophylline-binding RNA aptamer contains a 15 nucleotide motif that is required for high-affinity ligand binding. One residue within this RNA motif is only semiconserved and can be an A or C. This residue, C27, was disordered in the previously determined three-dimensional structure of the complex, suggesting that it is dynamic in solution. 13C Relaxation measurements are reported here, demonstrating that C27 is highly dynamic in the otherwise well-ordered RNA-theophylline complex. A synthetic complex with an abasic residue at position 27 was found to exhibit wild-type binding affinity (Kd approximately 0.2 microM), indicating that the base of residue 27 is not directly involved with theophylline binding. Surprisingly, the U27 and G27 RNAs were found to bind theophylline with low affinity (Kd values > 4 microM). NMR spectroscopy on the U27 RNA revealed the presence of an A7-U27 base pair in the free RNA that prevents formation of a critical base-platform structural motif and therefore blocks theophylline binding. Similarly, a protonated A7H+-C27 base pair forms in the absence of theophylline at low pH, which explains the unusual pH dependence of theophylline binding of the C27 RNA aptamer. Thus the weak binding for various nucleotides at position 27 arises not from unfavorable interactions in the RNA-theophylline complex but instead from stable interactions in the free state of the RNA that inhibit theophylline binding.
Rapid photorealistic blendshapes from commodity RGB-D sensors (2015)

Creating and animating a realistic 3D human face has been an important task in computer graphics. The capability of capturing the 3D face of a human subject and reanimate it quickly will find many applications in games, training simulations, and interactive 3D graphics. In this paper, we propose a system to capture photorealistic 3D faces and generate the blendshape models automatically using only a single commodity RGB-D sensor. Our method can rapidly generate a set of expressive facial poses from a single Microsoft Kinect and requires no artistic expertise on the part of the capture subject. The system takes only a matter of seconds to capture and produce a 3D facial pose and only requires 4 minutes of processing time to transform it into a blendshape model. Our main contributions include an end-to-end pipeline for capturing and generating face blendshape models automatically, and a registration method that solves dense correspondences between two face scans by utilizing facial landmark detection and optical flow. We demonstrate the effectiveness of the proposed method by capturing 3D facial models of different human subjects and puppeteering their models in an animation system with real-time facial performance retargeting.
Extracting Distorted Grid Points For Compensation Of Lens Radial Nonlinearities (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007
The influence of experimental manipulations on chewing speed during in vivo laboratory research in tufted capuchins (<i>Cebus apella</i>) (2011)

Even though in vivo studies of mastication in living primates are often used to test functional and adaptive hypotheses explaining primate masticatory behavior, we currently have little data addressing how experimental procedures performed in the laboratory influence mastication. The obvious logistical issue in assessing how animal manipulation impacts feeding physiology reflects the difficulty in quantifying mechanical parameters without handling the animal. In this study, we measured chewing cycle duration as a mechanical variable that can be collected remotely to: 1) assess how experimental manipulations affect chewing speed in Cebus apella, 2) compare captive chewing cycle durations to that of wild conspecifics, and 3) document sources of variation (beyond experimental manipulation) impacting captive chewing cycle durations. We find that experimental manipulations do increase chewing cycle durations in C. apella by as much as 152 milliseconds (ms) on average. These slower chewing speeds are mainly an effect of anesthesia (and/or restraint), rather than electrode implantation or more invasive surgical procedures. Comparison of captive and wild C. apella suggest there is no novel effect of captivity on chewing speed, although this cannot unequivocally demonstrate that masticatory mechanics are similar in captive and wild individuals. Furthermore, we document significant differences in cycle durations due to inter-individual variation and food type, although duration did not always significantly correlate with mechanical properties of foods. We advocate that the significant reduction in chewing speed be considered as an appropriate qualification when applying the results of laboratory-based feeding studies to adaptive explanations of primate feeding behaviors.