gebhart/patrepeval huggingface dataset:
1,4-Naphthoquinone and other nutrient requirements of Succinivibrio dextrinosolvens (1982)

Three strains of Succinivibrio dextrinosolvens isolated from the rumen of cattle or sheep under diverse conditions grew well in a minimal medium containing glucose, minerals, cysteine, methionine, leucine, serine, ammonia, 1,4-naphthoquinone, p-aminobenzoic acid, and bicarbonate-carbonic acid buffer, pH 6.7. When menadione or vitamin K5 was substituted for 1,4-naphthoquinone, the growth rate was somewhat depressed. Growth was poor with vitamin K1 and ammonia, further addition of the amino acids aspartic acid, arginine, histidine, and tryptophan was necessary for good growth of type strain 24, but the other two strains grew well only in media containing ammonia. Strains C18 and 22B produced urease and grew well when ammonia replaced urea. When urea replaced ammonia, strain 24 grew poorly and urease activity could not be detected. Strain 24 required no B-vitamins, but the other two strains were stimulated by p-aminobenzoic acid. The methionine requirement was not placed by vitamin B12, betaine, or homocysteine. Cysteine was replaced by sulfide in strain 24 but less well in the other two strains. Very poor growth was obtained when sulfate replaced cysteine. The half-saturation constant for ammonia during growth of S. dextrinosolvens is more than 500 microM, a much higher value than that of many rumen bacteria.
REESTRUCTURACION DE LA DIRECCION GENERAL DE ACTIVIDADES DEPORTIVAS Y RECREATIVAS (1985)

CON EL FIN DE COADYUVAR AL DESARROLLO INTEGRAL DE LOS ESTUDIANTES, JOSE MANUEL COVARRUBIAS, SECRETARIO GENERAL ADMINISTRATIVO DIO A CONOCER LA REESTRUCTURACION DE LA DIRECCION GENERAL DE ACTIVIDADES DEPORTIVAS Y RECREATIVAS, ASI COMO LA CREACION DEL CONSEJO TECNICO DEL DEPORTE UNIVERSITARIO.
Bioabsorbable materials for osteosynthesis and small joint arthroplasty in the hand (2008)

Fractures and arthritic joint destruction are common in the hand. A reliable and stable fracture fixation can be achieved by metal implants, which however, become unnecessary or even harmful after consolidation. The silicone implant arthroplasty is the current method of choice for reconstruction of metacarpophalangeal joints in rheumatoid patients. However, the outcome tends to worsen with long-term follow-up and implant-related complications become frequent. To address these problems, bioabsorbable implants were designed for the hand area. \n\nAims of the studies were: 1) to evaluate the biomechanical stabilities provided by self- reinforced (SR) bioabsorbable implants in a transverse and an oblique osteotomy of small tubular bones and to compare them with those provided by metal implants; 2) to evaluate the SR poly-L/DL-lactide 70/30 plate for osteosynthesis in a proof-of-principle type of experiment in three cases of hand injuries; and 3) to evaluate the poly-L/D-lactide (PLA) 96/4 joint scaffold, a composite joint implant with a supplementary intramedullary Polyactive® stem and Swanson silicone implant in an experimental small joint arthroplasty model. \n\nMethods used were: 1) 112 fresh frozen human cadaver and 160 pig metacarpal bones osteotomised transversally or obliquely, respectively, and tested ex vivo in three point bending and in torsion; 2) three patient cases of complex hand injuries; and 3) the fifth metacarpophalangeal joints reconstructed in 18 skeletally-mature minipigs and studied radiologically and histologically. \n\nThe initial fixation stabilities provided by bioabsorbable implants in the tubular bones of the hand were comparable with currently-employed metal fixation techniques, and were sufficient for fracture stabilisation in three preliminary cases in the hand. However, in torsion the stabilities provided by bioabsorbable implants were lower than that provided by metal counterparts. The bioabsorbable plate enhanced the bending stability for the bioabsorbable fixation construct. PLA 96/4 joint scaffolds demonstrated good biocompatibility and enabled fibrous tissue in-growth in situ. After scaffold degradation, a functional, stable pseudarthrosis with dense fibrous connective tissue was formed. However, the supplementary Polyactive® stem caused a deleterious tissue reaction and therefore the stem can not be applied to the composite joint implant. The bioabsorbable implants have potential for use in clinical hand surgery, but have to await validation in clinical patient series and controlled trials.
Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression (2018)

Flap endonuclease 1 (FEN1) overexpression promotes breast cancer. We investigated the role of FEN1 in cisplatin resistance and the chemosensitizing effects of curcumin in breast cancer cells. We demonstrated that FEN1 overexpression promotes cisplatin resistance in breast cancer cells, and that FEN1 knockdown enhances cisplatin sensitivity. Curcumin down-regulated FEN1 expression in a dose-dependent manner. A combination of cisplatin and curcumin enhanced breast cancer cell sensitivity to cisplatin by down-regulating FEN1 expression <i>in vitro</i> and <i>in vivo</i>. Increased ERK phosphorylation contributed to cisplatin resistance and cisplatin-induced FEN1 overexpression in breast cancer cells. Inhibiting ERK phosphorylation stimulated the chemosensitizing effect of curcumin to cisplatin by targeting FEN1. These data reveal that FEN1 overexpression promotes cisplatin resistance, and suggest FEN1 could be a potential therapeutic target to relieve cisplatin resistance in breast cancer. We also demonstrated that curcumin sensitizes breast cancer cells to cisplatin through FEN1 down-regulation.
Auto aligning system for narrow beam acoustic telemetry (1985)

Unmanned untethered submersibles can perform many tasks more effectively than can manned or tethered unmanned vehicles. Successful performance of these tasks often requires video feedback from the submersible to a remote operator. Acoustic high frequency attenuation and multipath conditions present serious obstacles to the transmission of video images, but these barriers can be lowered using narrow beam transducers and compressed video signals. These solutions, which maximize transmit bandwidth, requires that one transducer array always points at a second array. A tracking system has been constructed and is being tested to demonstrate a practical application of the principle of diverging beams.
Mechanisms of inhibitory effects of CoQ<sub>10</sub> on UVB‐induced wrinkle formation <i>in vitro</i> and <i>in vivo</i> (2008)

Photodamaged skin exhibits wrinkles, pigmented spots, dryness and tumors. Solar UV radiation induces cyclobutane pyrimidine dimers (CPD) and further produces base oxidation by reactive oxygen species (ROS). ROS are thought to be a major factor to initiate the up-regulation of matrix metalloproteinases (MMPs) in keratinocytes and fibroblasts via activation of receptor proteins on the cell membrane of keratinocytes and fibroblasts, and to degrade fiber components in dermis, leading to wrinkle formation. Coenzyme Q10 (CoQ10) was reported to reduce ROS production and DNA damage triggered by UVA irradiation in human keratinocytes in vitro. Further, CoQ10 was shown to reduce UVA-induced MMPs in cultured human dermal fibroblasts. We speculated that UVB radiation-induced cytokine production in keratinocytes may be inhibited by CoQ10, resulting in the reduction of MMPs in fibroblasts leading to wrinkle reduction. Our in vitro studies showed that UVB-induced IL-6 production of normal human keratinocyte (NHKC) decreased in the presence of CoQ10. Furthermore, MMP-1 production of fibroblasts cultured with the medium containing CoQ10 collected from UVB-irradiated NHKC significantly decreased during 24 h culture. In the clinical trial study, we found that the use of 1% CoQ10 cream for five months reduced wrinkle score grade observed by a dermatologist. Taken together, our results indicate that CoQ10 may inhibit the production of IL-6 which stimulate fibroblasts in dermis by paracrine manner to up-regulate MMPs production, and contribute to protecting dermal fiber components from degradation, leading to rejuvenation of wrinkled skin.
Development of a sensor for non-invasive intracranial pressure measurement in the newborn (1988)

A new system has been developed for the non-invasive monitoring of intracranial pressure (ICP) across the anterior fontanelle in the newborn. The system comprises a very small pneumatic sensor linked via two vinyl tubes to an instrument where the ICP value is displayed. The sensor is simply bonded to the anterior fontanelle, using industrial collodion normally used for attaching EEG electrodes. The sensor body is injection moulded in semi-flexible polyurethane with a very thin, compliant membrane bonded to its front surface. Using these manufacturing techniques the sensors are made to be disposable thus minimizing the risk of cross infection. ICP characteristics can now be recorded continuously in a wide range of neonates and the evaluation of currently used therapeutic treatments for lowering elevated ICP can be carried out safely and accurately.
Sleep Homeostasis and Cortical Synchronization: III. A High-Density EEG Study of Sleep Slow Waves in Humans (2007)

In the human EEG, the decline of SWA during sleep is accompanied by changes in slow-wave parameters that were predicted by a computer model simulating a homeostatic reduction of cortical synaptic strength.
[Morphological reasons of development of recurrent cystitis in children]. (2006)

Chronic cystitis was diagnosed in 36% of children with neuromuscular ureteral dysplasia, in 69% of those with vesicoureteral reflux, in 42% of girls with urolithiasis. Recurrent inflammation was registered in 96, 11% of patients with fibrinous cystitis and catarrhal cystitis, respectively, and in 62% of girls with bullous cystitis. Histological examination of 130 biopsies of bladder mucosa from girls with frequent recurrences of chronic cystitis provided a clear morphological picture of each endoscopic cystitis form. In bullous cystitis there are 2 congenital variants of mucosal structure: overdevelopment of lymphoid tissue as massive lymphoid follicules and lymphangioectatic form. Catarrhal cystitis is characterized by vascular angiomatosis. All the patients with fibrinous cystitis had squamous cell epithelial metaplasia. Morphological findings evidence that fibrinous cystitis is the most severe and unfavorable form of cystitis, bullous cystitis is less severe while catarrhal cystitis is favorable.
Clinical Significance of Epidermal Growth Factor Receptor Protein Overexpression and Gene Copy Number Gains in Prostate Cancer (2007)

Increased EGFR expression is often seen in prostate cancer and is associated with poor prognosis. The significant association of EGFR copy number gains with protein expression argues for the significant role of minimal gene copy number changes for protein expression. Although EGFR expression was not an independent prognostic variable, the potential utility of anti-EGFR medications might be worth further investigation in EGFR-expressing prostate cancer.
PLL modeling and verification in a cycle-simulation environment (1999)

Recent advances in technology, computer architecture, and automated design environments have ushered in a new era of computer design in which large complex servers such as the S/390 G5 Parallel Enterprise Server™ can be delivered with times to market once reserved for low-end systems such as single-user workstations and personal computers. Yet, the time to market is inversely proportional to customer demand for reliable and continuously available systems. Therefore, the need exists to build and simulate a complete system which incorporates realistic and accurate behavioral representations for all design components. This paper describes a method for modeling an analog phase-locked loop, interfacing it with digital sequential logic components, and simulating the entire system in a high-performance two-cycle simulation environment. Further discussion demonstrates the role this verification has played in the deployment of an improved design point with a shorter time to market compared to previous genera tions of S/390® CMOS machines.
The Role of Receptor for Advanced Glycation End Products in Airway Inflammation in CF and CF related Diabetes (2015)

Cystic Fibrosis (CF) is often accompanied by diabetes leading to worsening lung function, the reason for which is unclear. The receptor for advanced-glycation-end-products (RAGE) regulates immune responses and inflammation and has been linked to diabetes and possibly CF. We performed a pilot study to determine if CF and CF-related diabetes (CFRD) are associated with enhanced RAGE expression. Full length (fl)RAGE, soluble (s)RAGE, endogenous soluble (es)RAGE, S100A12 (enRAGE) and advanced-glycation-end-products (AGE) expression was assessed in serum, white blood cells and sputum of patients with CF; diabetes; CFRD and healthy subjects. Sputum enRAGE/sRAGE ratios were high in CF but particularly in CFRD which negatively correlated with % predicted FEV1. Serum AGE and AGE/sRAGE ratios were high in diabetics but not in CF. A complex, multifaceted approach was used to assess the role of RAGE and its ligands which is fundamental to determining their impact on airway inflammation. There is a clear association between RAGE activity in the airways of CF and CFRD patients that is not evident in the vascular compartment and correlates with lung function, in contrast to diabetes. This strongly suggests a role for RAGE in contributing to the inflammatory overdrive seen in CF and to a greater extent in CFRD.
A Systematic Review of the Relationships Between Physical Activity and Sleep in Early Childhood (2021)

The aim of this systematic review was to examine the associations between physical activity and sleep in children aged less than 6 years. Articles were included if participants were primarily aged less than 6 years and study designs were observational or experimental. Study characteristics were extracted, and the Grading Recommendations Assessment, Development and Evaluation framework was used to assess study quality. Thirty-six studies (16 sleep, 16 physical activity, and three fitness outcomes) from 18 countries reported in 29 articles were included. The majority of sleep and physical activity outcome studies reported mixed effects with very low to low quality of evidence. Fitness outcome studies were limited, and therefore, evidence was insufficient. The high prevalence of mixed and null results could be related to study limitations. Importantly, this review points to the critical need for higher quality studies of sleep and physical activity in young children, which would support health recommendations and intervention strategies for healthier child development.
High-speed data transmission using low-frequency clocks (1991)

An architecture for parallel-to-serial conversion that avoids high-frequency clocking is introduced. Instead of using fast clocks, it requires precise relative timing throughout the circuit. Such an approach is natural for an integrated circuit, where clock distribution is difficult, but devices in close proximity are very well matched. Roughly speaking, the architecture requires that the data be appropriately recorded, skewed with low-frequency clocks having precise phase mismatches, and merged through a combinational logic network with carefully matched delays. Both theory and implementation are discussed, although the approach is not closely tied to a specific technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Strata: scalable high-performance storage on virtualized non-volatile memory (2014)

Strata is a commercial storage system designed around the high performance density of PCIe flash storage. We observe a parallel between the challenges introduced by this emerging flash hardware and the problems that were faced with underutilized server hardware about a decade ago. Borrowing ideas from hardware virtualization, we present a novel storage system design that partitions functionality into an address virtualization layer for high performance network-attached flash, and a hosted environment for implementing scalable protocol implementations. Our system targets the storage of virtual machine images for enterprise environments, and we demonstrate dynamic scale to over a million IO operations per second using NFSv3 in 13µ of rack space, including switching.
Diamond penetrating electrode array for Epi-Retinal Prosthesis (2010)

This paper presents progress in the characterization and application of diamond penetrating electrode arrays for Epi-Retinal Prostheses. Electrical stimulation of degenerate retina has already been shown to restore partial vision for some blind patients, albeit at low spatial resolution. Higher resolution may be achievable by building arrays with electrodes that have greater areal density and closer proximity to target neurons. However, high standards of biocompatibility and hermeticity must be maintained, limiting the range of available materials of manufacture. Here, the design and histology of high density electrode arrays (approximately 100 electrodes/mm(2)) made from polycrystalline diamond and implanted into rat retinae are discussed. Results from initial steps in this process are reported.
A Highly Reactive Titanium Precatalyst for Intramolecular Hydroamination Reactions (2002)

[reaction: see text]. Tetrakisamido titanium complexes are significantly more active than Cp2TiMe2 (1) in the intramolecular hydroamination of aminoalkynes and aminoallenes. In the latter case, the regioselectivity of the transformation depends on the nature of the precatalyst, yielding the most selective and reactive catalysis with the bis(sulfonamido) complex 11.
The effect on dose of kilovoltage x-rays backscattered from lead (1992)

Dose enhancement on the backscatter side of a soft tissue/high Z material interface is known to exist for megavoltage x-ray beams. Caused by an increase in backscattered electron fluence, the enhancement persists for short distances upstream of the interface, equal to the range of these electrons. Since photon interaction cross sections are small, there is little photon backscatter at these energies. Consequently, beyond the range of the backscattered electrons, the dose upstream is unaffected by the presence of the interface. A similar dose enhancement has been reported for kilovoltage beams. In this case, due to the very low energy of the backscattered electrons, the enhancement persists for a very short upstream distance. Since photon interaction cross sections at keV energies are relatively large, there is also a substantial backscattered photon fluence. This experimental work investigates the effect of these photons on dose at distances upstream from a water/lead interface beyond the range of the backscattered electrons. Measurements of ionization charge, as a function of interface distance and field size for 60, 100, and 250 kV beams, were made with a parallel plate chamber at a fixed depth. A significant underdose was found upstream of the interface compared to a homogeneous water medium. For example, with the 100 kV beam and a 15 x 15 cm2 field the measured underdose is 23% at 3 mm and 14% at 1.5 cm upstream of the interface. The effect decreases with field size. In fact, for a 2 x 2 cm2 field the upstream dose in unaffected by the interface. Detailed results for this and the other two beams are presented along with backscatter factor measurements for lead. An explanation for the observed underdose is also presented.
Optimal excitation of permanent magnet synchronous machines via direct computation of electromagnetic force components (2005)

Vibration of the stator along with pulsation of the electromagnetic torque on the rotor are known as sources of acoustic noise in permanent magnet synchronous machines (PMSMs). Magnetic design and stator excitation can be tailored to mitigate undesirable vibrations which are viewed as byproducts in electromechanical energy conversion process. In this paper, using direct computation of the radial and tangential components of the electromagnetic force in the airgap of a PMSM, stator excitation for elimination of various force harmonics is presented. The proposed method is based on a field reconstruction method that rapidly calculates the radial and tangential flux density and force components under arbitrary stator excitation. Using the field reconstruction method, stator current waveforms that minimize the ripple of both torque and radial force are derived subject to the constraint of maintaining a satisfactory level of torque density
The Twin-Arginine Translocation Pathway of <i>Mycobacterium smegmatis</i> Is Functional and Required for the Export of Mycobacterial β-Lactamases (2005)

The twin-arginine translocation (Tat) pathway exports folded proteins across the bacterial cytoplasmic membrane and is responsible for the proper extracytoplasmic localization of proteins involved in a variety of cellular functions, including pathogenesis. The Mycobacterium tuberculosis and Mycobacterium smegmatis genomes contain open reading frames with homology to components of the Tat export system (TatABC) as well as potential Tat-exported proteins possessing N-terminal signal sequences with the characteristic twin-arginine motif. Due to the importance of exported virulence factors in the pathogenesis of M. tuberculosis and the limited understanding of mycobacterial protein export systems, we sought to determine the functional nature of the Tat export pathway in mycobacteria. Here we describe phenotypic analyses of DeltatatA and DeltatatC deletion mutants of M. smegmatis, which demonstrated that tatA and tatC encode components of a functional Tat system capable of exporting characteristic Tat substrates. Both mutants displayed a growth defect on agar medium and hypersensitivity to sodium dodecyl sulfate. The mutants were also defective in the export of active beta-lactamases of M. smegmatis (BlaS) and M. tuberculosis (BlaC), both of which possess twin-arginine signal sequences. The Tat-dependent nature of BlaC was further revealed by mutation of the twin-arginine motif. Finally, we demonstrated that replacement of the native signal sequence of BlaC with the predicted Tat signal sequences of M. tuberculosis phospholipase C proteins (PlcA and PlcB) resulted in the Tat-dependent export of an enzymatically active 'BlaC. Thus, 'BlaC can be used as a genetic reporter for Tat-dependent export in mycobacteria.
Mechanism of Aromatic Hydrocarbon Formation in FCC Naphtha (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of Aromatic Hydrocarbon Formation in FCC NaphthaClaudio J. A. Mota and Raul RawetCite this: Ind. Eng. Chem. Res. 1995, 34, 12, 4326–4332Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ie00039a024https://doi.org/10.1021/ie00039a024research-articleACS PublicationsRequest reuse permissionsArticle Views387Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts