gebhart/patrepeval huggingface dataset:
Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit. (1991)

The large carboxy-terminal globular domain (G domain; residues 2,110-3,060) of the A chain of murine-derived laminin has been shown to promote heparin binding, cell adhesion, and neurite outgrowth. This study was conducted to define the potential sequence(s) originating from the G domain of laminin with any of these functional activities. A series of peptides were synthesized from the G domain, termed GD peptides, each approximately 20 amino acids long and containing multiple positively charged amino acids. In direct 3H-heparin binding assays, peptides GD-1 and GD-2 bound high levels of 3H-heparin, while peptides GD-3 and GD-4 bound lower levels of 3H-heparin, and GD-5 bound essentially no 3H-heparin. The binding of 3H-heparin to peptides GD-1 and GD-2 appeared to be of high affinity, since significant binding of 3H-heparin to these two peptides was still observed even when the NaCl concentration was raised to 1.0 M. Four of the peptides, GD-1, GD-2, GD-3, and GD-4, directly promoted the adhesion and spreading of HT-1080 human fibrosarcoma cells as well as the outgrowth of neurites from chick spinal cord and dorsal root ganglia neurons. In addition, solutions of these peptides or antibodies generated against these peptides inhibited laminin-mediated HT-1080 cell adhesion. Antibodies against the beta 1 integrin subunit inhibited HT-1080 cell adhesion and neurite outgrowth on surfaces adsorbed with peptides GD-3 and GD-4. Therefore, laminin appears to have multiple, independent sequences in the G domain that serve a similar cell adhesion promoting function for different cell types. Furthermore, these results suggest that the sequences comprising peptides GD-3 and GD-4 use an integrin as a receptor, of which the beta 1 integrin subunit is a component for these various cell types.
TaG-Games: Tangible geometric games for assessing cognitive problem-solving skills and fine motor proficiency (2010)

This paper presents Tangible Geometric Games (TaG-Games) as a novel play-based assessment tool for measuring cognitive problem-solving skills and fine motor proficiency. TaG-Games are based on sensor-integrated geometric blocks (SIG-Blocks) and an interactive graphical user interface providing a means for real-time and remote monitoring of a player through wireless communication between the blocks and a host computer. The data made available by employing TaG-Games includes: 1) accelerations, 2) time at each stage of assembly completion, 3) total completion time for each quiz, and 4) correctness of each assembly step. In addition, the user interface displays the real-time assembly configuration of the blocks. As a computational method for analyzing complexity associated with geometric play, a quantitative measure of play complexity is defined based on an information-theoretic approach. The validity of the sensors integrated in each SIG-Block (an accelerometer and optical sensors) is evaluated for measuring tilt angles and detecting assemblies between the blocks.
Glucose metabolism in pigs expressing human genes under an insulin promoter (2014)

Multiple islet-targeted transgenic expression was not associated with an overtly detrimental effect on islet function, suggesting that complex genetic constructs designed for islet protection warrants further testing in islet xenotransplantation models.
Thermal Shock Behavior of an Alumina‐SiC Whisker Composite (1987)

Thermal shock testing of an alumina‐20 vol% SiC whisker composite showed no decrease in flexural strength with temperature differences up to 900°C. Alumina, on the other hand, normally shows a significant decrease inflexural strength with a temperature change of >400°C. The improvement in the thermal shock resistance of the composite is believed attributable to the increased fracture toughness of this material.
Application of Fullerenes to Nanodevices (2010)

This chapter contains sections titled: Introduction Synthesis of Transition Metal Fullerene Complexes Organometallic Chemistry of Metal Fullerene Complexes Synthesis of Multimetal Fullerene Complexes Supramolecular Structures of Penta(organo)[60]fullerene Derivatives Reduction of Penta(organo)[60]fullerenes to Generate Polyanions Photoinduced Charge Separation Photocurrent-Generating Organic and Organometallic Fullerene Derivatives Conclusion References
SPARCOM: Sparsity Based Super-resolution Correlation Microscopy (2019)

In traditional optical imaging systems, the spatial resolution is limited by the physics of diffraction, which acts as a low-pass filter. The information on subwavelength features is carried by evanescent waves, never reaching the camera, thereby posing a hard limit on resolution: the so-called diffraction limit. Modern microscopic methods enable super-resolution, by employing fluorescence techniques. State-of-the-art localization based fluorescence subwavelength imaging techniques such as PALM and STORM achieve subdiffraction spatial resolution of several tens of nanometers. However, they require tens of thousands of exposures, which limits their temporal resolution. We have recently proposed sparsity based super-resolution correlation microscopy (SPARCOM), which exploits the sparse nature of the fluorophore distribution, alongside a statistical prior of uncorrelated emissions, and showed that SPARCOM achieves spatial resolution comparable to PALM/STORM, while capturing the data hundreds of times faster. Here, we provide a detailed mathematical formulation of SPARCOM, which in turn leads to an efficient numerical implementation, suitable for large-scale problems. We further extend our method to a general framework for sparsity based super-resolution imaging, in which sparsity can be assumed in other domains such as wavelet or discrete-cosine, leading to improved reconstructions in a variety of physical settings.
Uptake of the antisecretory factor peptide AF-16 in rat blood and cerebrospinal fluid and effects on elevated intracranial pressure (2014)

Optimal AF-16 concentrations in CSF are achieved after intranasal administration in rats subjected to a cryogenic brain injury. The ability of AF-16 to suppress an increased ICP was manifested.
Saliency enhancement of salient pole wound field synchronous machines for variable speed applications (2017)

In variable speed applications, machines with variable field flux such as wound field synchronous machines (WFSMs), inherently have advantages in loss saving compared to fixed field flux drives such as permanent magnet (PM) machines in field-weakening region. However, the WFSM normally lacks the ability to produce as much reluctance torque as the PM machine due to its negligible saliency. This paper introduces a low cost flux barrier structure in the rotor design to improve the saliency and thus the torque production of a conventional synchronous machine. Effects of the WFSM parameters on torque and output power capability are first investigated using the d <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</sub> equivalent circuit model. Observations are: (1) it is beneficial to have a larger saliency design to improve maximum torque capability and save copper losses, (2) the choice of d-axis synchronous reactance needs to be carefully made to achieve decent corner speed and corner torque at the same time, (3) good torque (power) speed capability can be achieved with a large saliency design. Results are then verified with finite element (FE) calculations. A comparison is made with a conventional salient pole structure whereby it is shown that total loss is reduced in the field-weakening region and efficiency is improved as a result, making this machine a serious candidate for traction applications.
Enhanced prion detection in biological samples by magnetic particle extraction and real-time quaking-induced conversion (2016)

Prions have been demonstrated in body fluids and excreta using bioassay, but at levels too low for detection by conventional direct-detection assays. More rapid and sensitive detection of prions in these clinically accessible specimens would be valuable for diagnosis and investigations of transmission, environmental impact, and interventions. In addition to very low concentrations of prions, in vitro amplification assays are challenged by the presence of inhibitors in these complex sources. Here, we leverage the prion attribute of avid metal binding with the versatile power of real-time quaking-induced conversion (RT-QuIC) to enhance and simplify detection of chronic wasting-disease prions in biological samples. Iron oxide particle binding and magnetic extraction combined with RT-QuIC permitted rapid analysis of the low concentrations of prions in saliva, urine, faeces, and cerebrospinal fluid. These methods are pertinent to ante-mortem detection, monitoring, and surveillance, and could conceivably be applicable to other protein-misfolding disorders.
1,1'-Diphosphaferrocenes. Synthesis, basic chemistry, and structure (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,1'-Diphosphaferrocenes. Synthesis, basic chemistry, and structureGuillaume De Lauzon, Bernard Deschamps, Jean Fischer, Francois Mathey, and Andre MitschlerCite this: J. Am. Chem. Soc. 1980, 102, 3, 994–1000Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ja00523a015https://doi.org/10.1021/ja00523a015research-articleACS PublicationsRequest reuse permissionsArticle Views365Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Abstract 754: Development of death receptor agonists for breast cancer therapy (2010)

Abstract TRAIL and death receptor (TRAIL-R1 and TRAIL-R2) agonistic antibodies have been shown to induce apoptosis in cancer cells and their clinical trials have produced positive results. However, there are no small organic molecular weight compounds that bind to TRAIL-death receptors and induce apoptosis specifically in cancer cells. The purpose of this study was to identify and characterize death receptor agonists (DRAs)/ small molecular weight organic compounds that induce apoptosis in breast cancer cells. The pharmacokinetics of the DRA with a single oral dose was characterized in nude mice. Blood was collected over 72 hour period after drug administration, and analyzed by HPLC-MS/MS for plasma drug concentration. The Cmax, tmax, and AUC of DRA was measured. DRAs inhibited cell viability and colony formation, and induced apoptosis in estrogen-dependent (MCF-7) and independent (MDA-MB-231 and MDA-MB-468) human breast cancer cell lines, but had no effect on human normal mammary epithelial cells and hepatocytes. The ability of DRAs to induce apoptosis was further enhanced in the presence of TRAIL. DRAs formed active TRAIL-DISC (death-inducing signaling complex) similar to that of TRAIL. DRAs inhibited the growth of orthotopically implanted MDA-MB-231 and MDA-MB-468 tumors in nude mice. Histological examination of tumor tissues derived from DRAs-treated nude mice revealed massive caspase-3 activation and apoptosis. Pharmacokinetic data demonstrate that DRA possesses a long terminal half-life, which is acceptable for further clinical development. In conclusion, we have identified, for the first time, DRAs that can be used in the clinic for the treatment of human breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 754.
Deep Cytometry (2019)

Deep learning has achieved spectacular performance in image and speech recognition and synthesis. It outperforms other machine learning algorithms in problems where large amounts of data are available. In the area of measurement technology, instruments based on the photonic time stretch have established record real-time measurement throughput in spectroscopy, optical coherence tomography, and imaging flow cytometry. These extreme-throughput instruments generate approximately 1 Tbit/s of continuous measurement data and have led to the discovery of rare phenomena in nonlinear and complex systems as well as new types of biomedical instruments. Owing to the abundance of data they generate, time-stretch instruments are a natural fit to deep learning classification. Previously we had shown that high-throughput label-free cell classification with high accuracy can be achieved through a combination of time-stretch microscopy, image processing and feature extraction, followed by deep learning for finding cancer cells in the blood. Such a technology holds promise for early detection of primary cancer or metastasis. Here we describe a new deep learning pipeline, which entirely avoids the slow and computationally costly signal processing and feature extraction steps by a convolutional neural network that directly operates on the measured signals. The improvement in computational efficiency enables low-latency inference and makes this pipeline suitable for cell sorting via deep learning. Our neural network takes less than a few milliseconds to classify the cells, fast enough to provide a decision to a cell sorter for real-time separation of individual target cells. We demonstrate the applicability of our new method in the classification of OT-II white blood cells and SW-480 epithelial cancer cells with more than 95% accuracy in a label-free fashion.
Focusing light inside scattering media with magnetic-particle-guided wavefront shaping (2017)

Optical scattering has traditionally limited the ability to focus light inside scattering media such as biological tissue. Recently developed wavefront shaping techniques promise to overcome this limit by tailoring an optical wavefront to constructively interfere at a target location deep inside scattering media. To find such a wavefront solution, a "guide-star" mechanism is required to identify the target location. However, developing guidestars of practical usefulness is challenging, especially in biological tissue, which hinders the translation of wavefront shaping techniques. Here, we demonstrate a guidestar mechanism that relies on magnetic modulation of small particles. This guidestar method features an optical modulation efficiency of 29% and enables micrometer-scale focusing inside biological tissue with a peak intensity-to-background ratio (PBR) of 140; both numbers are one order of magnitude higher than those achieved with the ultrasound guidestar, a popular guidestar method. We also demonstrate that light can be focused on cells labeled with magnetic particles, and to different target locations by magnetically controlling the position of a particle. Since magnetic fields have a large penetration depth even through bone structures like the skull, this optical focusing method holds great promise for deep-tissue applications such as optogenetic modulation of neurons, targeted light-based therapy, and imaging.
ReViNE: Reallocation of Virtual Network Embedding to eliminate substrate bottlenecks (2017)

Perceived as a key enabling technology for the future Internet, Network Virtualization (NV) allows an Infrastructure Provider (InP) to better utilize their Substrate Network (SN) by provisioning multiple Virtual Networks (VNs) from different Service Providers (SPs). A key challenge in NV is to efficiently map the VN requests from SPs on an SN, known as the Virtual Network Embedding (VNE) problem. VNE algorithms are typically online in nature. A VN embedding can become suboptimal over time due to the arrival and departure of other VNs as well as due to changes in SN such as failures. One way to mitigate the impact of such dynamism is to periodically reallocate resources for the existing VNs. VNE reallocation can increase an InP's revenue by decreasing bandwidth consumption and by increasing the possibility of accepting future VNs. In this paper, we study Reallocation of Virtual Network Embedding (ReViNE) problem to minimize the number of over utilized substrate links and total bandwidth cost on the SN. We propose an Integer Linear Programming formulation for the optimal solution (ReViNE-OPT) and a simulated annealing based heuristic (ReViNE-FAST) to solve larger problem instances. Simulation results show that on average our proposed heuristic performs within ∼19% of the optimal solution. Moreover, ReViNE-FAST generates more than 2.5× better solutions compared to the state-of-the-art simulated annealing based heuristic for VNE reallocation.
Probing the Quenching of Quantum Dot Photoluminescence by Peptide-Labeled Ruthenium(II) Complexes (2014)

Charge transfer processes with semiconductor quantum dots (QDs) have generated much interest for potential utility in energy conversion. Such configurations are generally nonbiological; however, recent studies have shown that a redox-active ruthenium(II)-phenanthroline complex (Ru<sup>2+</sup>-phen) is particularly efficient at quenching the photoluminescence (PL) of QDs, and this mechanism demonstrates good potential for application as a generalized biosensing detection modality since it is aqueous compatible. Multiple possibilities for charge transfer and/or energy transfer mechanisms exist within this type of assembly, and there is currently a limited understanding of the underlying photophysical processes in such biocomposite systems where nanomaterials are directly interfaced with biomolecules such as proteins. Here, we utilize redox reactions, steady-state absorption, PL spectroscopy, time-resolved PL spectroscopy, and femtosecond transient absorption spectroscopy (FSTA) to investigate PL quenching in biological assemblies of CdSe/ZnS QDs formed with peptide-linked Ru<sup>2+</sup>-phen. The results reveal that QD quenching requires the Ru<sup>2+</sup> oxidation state and is not consistent with Förster resonance energy transfer, strongly supporting a charge transfer mechanism. Further, two colors of CdSe/ZnS core/shell QDs with similar macroscopic optical properties were found to have very different rates of charge transfer quenching, by Ru<sup>2+</sup>-phen with the key difference between them appearing to be the thickness of their ZnS outer shell. The effect of shell thickness was found to be larger than the effect of increasing distance between the QD and Ru<sup>2+</sup>-phen when using peptides of increasing persistence length. FSTA and time-resolved upconversion PL results further show that exciton quenching is a rather slow process consistent with other QD conjugate materials that undergo hole transfer. An improved understanding of the QD-Ru<sup>2+</sup>-phen system can allow for the design of more sophisticated charge-transfer-based biosensors using QD platforms.
Test Method for Measuring Bit Error Rate of Pulsed Transceivers in Presence of Narrowband Interferers (2007)

The popularity of pulse-based transceivers can be attributed to the high information rates that can be achieved in such systems compared to traditional narrowband systems. However, such systems are usually low-power and transmission efficiency is severely affected by the interference signals from other moderate to high-power narrowband transmitters. Hence, during manufacturing, pulse-based systems must be characterized and tested for bit error rate (BER) performance in the presence of narrowband interferers. Usually, at large interference levels, the BER is moderate (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> ) to high (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ). However, at low interference levels when very few bits are in error, the BER is low (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> - 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-10</sup> ) and testing for the BER becomes time consuming. We propose a new measurement technique employing sinusoidal pulses such that the BER value obtained is significantly large (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> - 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> ) even at low interference levels. BER values obtained using sinusoidal pulses are highly correlated to the actual BER values. Hence, the actual BER can be accurately estimated in a much smaller time without actually performing the standard test. This method was implemented in hardware using an Altera field-programmable gate-array development board. From the measurements, BER estimation error was less than 3%. In addition, significant reduction (up to 100 x) in test time was obtained using the proposed method.
CP-54,883 a novel chlorine-containing polyether antibiotic produced by a new species of Actinomadura: Taxonomy of the producing culture, fermentation, physico-chemical and biological properties of the antibiotic. (1987)

The novel chlorine-containing acidic polycyclic ether antibiotic CP-54,883 (C41H62O12Cl2) [corrected] is produced by the fermentation of Actinomadura routienii Huang sp. nov. This report presents the taxonomy and the fermentation conditions for the antibiotic-producing culture. The antibiotic is mainly active against Gram-positive bacteria. It protects chickens against Eimeria challenge in vivo and enhances rumen propionic acid in vitro. The physico-chemical properties are also characterized.
Development of position sensitive proportional counters for hot particle detection in laundry and portal monitors (1992)

This report summarizes research which demonstrates the use of position sensitive proportional counters in contamination monitoring systems. Both laundry monitoring and portal monitoring systems were developed. The laundry monitor was deployed at a nuclear power plant where it was used to monitor clothing during an outage. Position sensitive proportional counter based contamination monitoring systems were shown to have significant advantages over systems using conventional proportional counters. These advantages include the ability to directly measure the area and quantity of contamination. This capability permits identification of hot particles. These systems are also capable of self calibration via internal check sources. Systems deployed with this technology should benefit from reduced complexity, cost and maintenance. The inherent reduction of background that occurs when the counter is electronically divided into numerous detectors permits operation in high background radiation fields and improves detection limits over conventional technology.