gebhart/patrepeval huggingface dataset:
Erythrocyte Organic Phosphates and Hemoglobin Function in Birds, Reptiles, and Fishes (1980)

Studies on the role of red blood cell organic phosphates in regulating oxygen transport and hemoglobin function in various species have emanated from several laboratories in the past few years. These data reveal that the organic phosphate composition of erythrocytes is certainly more diverse between classes of animals than previously recognized, that the kind and concentration of red cell organic phosphate modulator changes during development of the species and that the role of organic phosphates in modulating hemoglobin function is variable. For example in birds we believe that the changes in amounts and distribution of the intraerythrocytic organic phosphates account for the sudden changes in whole blood oxygen affinity during development of the embryo and young bird as well as in the mature bird. In the loggerhead and green sea turtle it appears that organic phosphate modulators regulate whole blood oxygen affinity during embryonic development but it is unlikely that whole blood oxygen affinity is controlled by organic phosphate modulation of hemoglobin function in the adult turtle. From the data now available on air-breathing fishes, it appears reasonable to consider that whole blood oxygen affinity may be regulated by a combination of organic phosphates that is the relative concentrations of the primary regulator (inositol-P2 2,3-DPG, or inositol P5) may be rather stable whereas the nucleotide triphosphate (ATP and GTP) concentrations may fluctuate depending upon physiological demands upon the animal for oxygen.
Facile synthesis of indene and fluorene derivatives through AlCl<sub>3</sub>‐catalyzed cyclization of in situ formed iminium ions (2017)

A simple AlCl 3 ‐catalyzed condensation/cyclization cascade process between aldehydes and sulfonamide is reported, in which two new bonds and one five‐membered ring are simultaneously formed with water as the byproduct. This method provides a rapid access to indenamine and 9‐aminofluorene derivatives. Additionally, these products can be transformed into corresponding indanones and fluorenones under the developed conditions.
Miniature fiber optic pressure sensor for medical applications: an opportunity for intra-aortic balloon pumping (IABP) therapy (2005)

In this paper we present how a miniature fiber optic pressure sensor based on micro-optical mechanical systems (MOMS) could solve most of the problems associated with fluidic pressure transduction presently used for triggering purposes in IABP therapy. The small size of the MOMS (0 550 μm) allows a positioning of the sensor directly at the tip of the intra-aortic catheter, exactly where the pressure should be monitored. With outstanding performances in terms of resolution and frequency fidelity, this absolute pressure sensor can precisely detect small pressure variations such as the dicrotic notch in the intra-aortic pressure waveform, which is used as a trigger point in IABP therapy. Such technology could probably help in the development of a less invasive therapy with reduced catheter size associated with reduction of vascular complications such as ischemia. The presented optical fiber sensor has intrinsic immunity to electromagnetic fields and noise perturbations. Furthermore, the patented white-light cross-correlation technology of the signal conditioner makes it immune to optical fiber binding and highly tolerant to optical losses. Such solution is extremely well adapted for in situ pressure monitoring in many medical applications.
How Facebook is used to promote ENDS products near four Big 10 universities: A qualitative analysis (2022)

<b>Objective: </b>Electronic Nicotine Delivery System (ENDS) proprietors strategically placed near college campuses and pervasive marketing on social media platforms, such as Facebook, are critical to the tobacco industry's effort to acquire new young adult users. Understanding the themes used on Facebook to promote ENDS products to college students is necessary to develop public health messaging to combat the vaping epidemic.<b>Methods: </b>We identified 15 ENDS proprietors located near four Big 10 universities and qualitatively analyzed a random sample of their Facebook posts (<i>n =</i> 405) to identify emerging themes using a grounded theory approach.<b>Results: </b>ENDS proprietors in college towns use Facebook to deploy <i>promotional</i> messaging (<i>n =</i> 319), to market ENDS products as a means of <i>celebration</i> (<i>n =</i> 40), to establish a sense of <i>community</i> (<i>n =</i> 155) among ENDS users, to make <i>marijuana references</i> (<i>n =</i> 36), and to <i>advocate</i> (<i>n =</i> 27) for ENDS products.<b>Conclusions: </b>These themes may increase social acceptability and use of ENDS products among college students.
Laser Beam Combining Technology (1987)

Single laser elements will always have an upper limit of power. Progress in technology continuously demands higher power. This could be satisfied by developing a parallel but generic technology of laser beam combiner. Current state of technology is summarized from this "generic" point of view, categorizing the specific approaches that exploit the various parameters (or properties) of light beam and/or laser cavities.
PROVISIONAL RECOMMENDATIONS ON IFCC METHODS FOR THE MEASUREMENT OF CATALYTIC CONCENTRATIONS OF ENZYMES (1977)

Journal Article PROVISIONAL RECOMMENDATIONS ON IFCC METHODS FOR THE MEASUREMENT OF CATALYTIC CONCENTRATIONS OF ENZYMES Get access H U Bergmeyer, H U Bergmeyer Tutzing (G.F.R.) Search for other works by this author on: Oxford Academic Google Scholar G N Bowers, Jr., G N Bowers, Jr. Hartford, Conn. (U.S.A.) Search for other works by this author on: Oxford Academic Google Scholar M Hørder, M Hørder Århus (Denmark) Search for other works by this author on: Oxford Academic Google Scholar D W Moss D W Moss London (U.K.)(Chairman) Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 23, Issue 5, 1 May 1977, Pages 887–899, https://doi.org/10.1093/clinchem/23.5.887 Published: 01 May 1977
Biologically Active and Other Chemical Constituents of the Herb of<i>Hypericum perforatum</i>L. (1997)

Phenylpropanes, flavonol derivatives, biflavones, proanthocyanidins, xanthones, phloroglucinols, some amino acids, naphthodianthrones and essential oil constituents are the natural plant products known from the crude drug of Hypericum perforatum, Hyperici herba. These compounds are discussed with respect to structural features, their concentration, biological activities and their possible contribution to the clinically demonstrated antidepressant efficacy of extracts obtained from Hyperici herba.
Role of Heteromultimers in the Generation of Myocardial Transient Outward K <sup>+</sup> Currents (2002)

Previous studies have demonstrated a role for Kv4 alpha subunits in the generation of the fast transient outward K+ current, I(to,f), in the mammalian myocardium. The experiments here were undertaken to explore the role of homomeric/heteromeric assembly of Kv4.2 and Kv4.3 and of the Kv channel accessory subunit, KChIP2, in the generation of mouse ventricular I(to,f). Western blots reveal that the expression of Kv4.2 parallels the regional heterogeneity in I(to,f) density, whereas Kv4.3 and KChIP2 are uniformly expressed in adult mouse ventricles. Antisense oligodeoxynucleotides (AsODNs) targeted against Kv4.2 or Kv4.3 selectively attenuate I(to,f) in mouse ventricular cells. Adenoviral-mediated coexpression of Kv4.2 and Kv4.3 in HEK-293 cells and in mouse ventricular myocytes produces transient outward K+ currents with properties distinct from those produced on expression of Kv4.2 or Kv4.3 alone, and the gating properties of the heteromeric Kv4.2/Kv4.3 channels in ventricular cells are more similar to native I(to,f) than are the homomeric Kv4.2 or Kv4.3 channels. Biochemical studies reveal that Kv4.2, Kv4.3, and KChIP2 coimmunoprecipitate from adult mouse ventricles. In addition, most of the Kv4.2 and KChIP2 are associated with Kv4.3 in situ. Taken together, these results demonstrate that functional mouse ventricular I(to,f) channels are heteromeric, comprising Kv4.2/Kv4.3 alpha subunits and KChIP2. The results here also suggest that Kv4.2 is the primary determinant of the regional heterogeneity in I(to,f) expression in adult mouse ventricle.
Accelerated Conversion of Human Plasminogen Activator Inhibitor-1 to Its Latent Form by Antibody Binding (1999)

The serpin plasminogen activator inhibitor-1 (PAI-1) slowly converts to an inactive latent form by inserting a major part of its reactive center loop (RCL) into its beta-sheet A. A murine monoclonal antibody (MA-33B8), raised against the human plasminogen activator (tPA).PAI-1 complex, rapidly inactivates PAI-1. Results presented here indicate that MA-33B8 induces acceleration of the active-to-latent conversion. The antibody-induced inactivation of PAI-1 labeled with the fluorescent probe N, N'-dimethyl-N-(acetyl)-N'-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) ethylene diamine (NBD) at P9 in the RCL caused a fluorescence enhancement and shift identical to those accompanying the spontaneous conversion of the P9.NBD PAI-1 to the latent form. Like latent PAI-1, antibody-inactivated PAI-1 was protected from cleavage by elastase. The rate constants for MA-33B8 binding, measured by NBD fluorescence or inactivation, were similar (1.3-1.8 x 10(4) M-1 s-1), resulting in a 4000-fold faster inactivation at 4.2 microM antibody binding sites. The apparent antibody binding rate constant, at least 1000 times slower than one limited by diffusion, indicates that exposure of its epitope depends on an unfavorable equilibrium of PAI-1. Our observations are consistent with this idea and suggest that the equilibrium involves partial insertion of the RCL into sheet A: latent, RCL-cleaved, and tPA-complexed PAI-1, which are inactive loop-inserted forms, bound much faster than active PAI-1 to MA-33B8, whereas two loop-extracted forms of PAI-1, modified to prevent loop insertion, did not bind or bound much more weakly to the antibody.
Tyrosine phosphorylation of phospholipase C concomitant with its activation by platelet-activating factor in a human B cell line. (1993)

Platelet-activating factor (PAF) is a powerful inflammatory mediator in a variety of systems. Upon binding its receptor on B lymphocytes, it activates phospholipases C and A2, thus initiating a cascade of events culminating in changes in the program of the target cell. We have now extended our previous studies of the effects of PAF on EBV-transformed human B cell lines to examine the mechanism by which phospholipase C (PLC) is activated. PAF-induced incorporation of 32P into phosphatidylinositol (PtdIns) was markedly diminished by the tyrosine kinase inhibitors, genistein, and those of the tyrphostin family, tyrphostins 25, 47, and 51. The generation of inositol phosphates induced by PAF was also significantly inhibited by these inhibitors. Correlating with this inhibition of PtdIns turnover, the elevation of intracellular calcium concentrations stimulated by PAF was observed to be inhibited in the presence of inhibitors of tyrosine kinases. In addition, the induction of expression of the proto-oncogene, c-fos, was substantially attenuated by these inhibitors. Finally, employing anti-phosphotyrosine immunoprecipitates of lysates from PAF-stimulated cells in an in vitro PLC assay, we have provided evidence for an increase in the tyrosine phosphorylation levels of PLC upon stimulation, and the inhibition of this increase by tyrosine kinase inhibitors. In summary, we have shown that in B cells tyrosine kinase activity is essential for the PtdIns turnover, the generation of inositol phosphates, and the calcium flux induced by PAF and that platelet-activating factor-induced tyrosine phosphorylation of PLC is likely to be required for the activation of this enzyme.
An energy-efficient reconfigurable DTLS cryptographic engine for End-to-End security in iot applications (2018)

End-to-end security protocols, like Datagram Transport Layer Security (DTLS) [1], enable the establishment of mutually authenticated confidential channels between edge nodes and the cloud, even in the presence of untrusted and potentially malicious network infrastructure. While this makes DTLS an ideal solution for IoT, the associated computational cost makes software-only implementations prohibitively expensive for resource-constrained embedded devices. We address this challenge through three key contributions: reconfigurable cryptographic accelerators enable two orders of magnitude energy savings, a dedicated DTLS engine offloads control flow to hardware reducing program code and memory usage by ∼10x, and an on-chip RISC-V core exercises the flexibility of the cryptographic accelerators to demonstrate security applications beyond DTLS.
OPO reduction by novel target design (2020)

On product overlay (OPO) shrink is a key enabler to achieve high yield in integrated circuit manufacturing. One of the key factors to enable accurate measurement on grid (target) is the use of optimized overlay (OVL) mark design to achieve low OPO. The OVL mark design enables accurate and robust OVL metrology and improves measurability and basic performance requirements such as total measurement uncertainty (TMU). In this paper, we demonstrate the methodology of mark design for different devices based on simulations, measurements and verification. We compare OVL performance of AIM® targets and grating-over-grating imaging targets utilizing the Moiré effect. Methodologies described in this work utilize robust AIM (rAIM™) targets, target design from the MTD AcuRate™ simulation-based OVL metrology target design tool, and the Archer™ OVL metrology system.
Changes in the activity of some hepatic enzymes during organophosphorus insecticide-acephate (orthene) treatment in albino rats. (1983)

Acephate, an organophosphorus insecticide (60 mg/day/rat) disturbed the carbohydrate metabolism in albino rats (wt. between 100-150 gms). Changes in the enzyme activities in the liver were estimated in the rats after oral administration of Acephate. The specific activities of succinic dehydrogenase was decreased in experimental rats than control. A gradual decrease in blood and liver glutathione was also observed. Increase in total lactate dehydrogenase was also noted. It has been observed that in the liver homogenate of treated rats, the isoenzymes LDH4+5 were increased, LDH1+2 were decreased while LDH3 remain unchanged with respect to control value.
<i>VKORC1</i> Polymorphisms, Haplotypes and Haplotype Groups on Warfarin Dose Among African–Americans and European–Americans (2008)

Our findings support the use of CYP2C9, VKORC1 polymorphisms (rs9934438 or rs9923231) and clinical covariates to predict warfarin dose in both African- and European-Americans. A uniform set of common polymorphisms in CYP2C9 and VKORC1, and limited clinical covariates can be used to improve warfarin dose prediction for a racially diverse population.
Effect of plasma-induced charging damage on n-channel and p-channel MOSFET hot carrier reliability (1994)

We have investigated the impact of plasma-induced charging damage on the hot carrier reliability of n- and p-MOSFET's, including the examination of different stress bias regimes and the statistical distributions of hot carrier failure times. We found that when electron trapping determines hot carrier failure-as in p-MOSFETs stressed under the peak gate current condition-the median time-to-fail was dramatically reduced while the dispersion in the failure data was increased as plasma damage increased. Interface trap dominated hot carrier degradation-as in n-MOSFET's stressed under the peak substrate current condition or p-MOSFET's stressed at V/sub gs/=V/sub ds/-was not affected by plasma damage. Then both electron trapping and interface trap generation impact hot carrier degradation-as in n-MOSFET's stressed at V/sub gs/=V/sub ds/-plasma damage had a measurable but smaller effect on the failure statistics. These results are explained in terms of the differing impact of thermal annealing on bulk and interface traps. Finally, we show that reduced damage processes can mitigate the impact of plasma damage on MOSFET hot carrier robustness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis and characterization of vertically standing MoS2 nanosheets (2016)

Molybdenum disulfide (MoS2) has been attracting much attentions due to its excellent electrical and optical properties. We report here the synthesis of large-scale and uniform MoS2 nanosheets with vertically standing morphology using chemical vapor deposition method. TEM observations clearly reveal the growth mechanism of these vertical structures. It is suggested that the vertical structures are caused by the compression and extrusion between MoS2 islands. More importantly, the vertical morphology of two dimensional (2D) materials hold many promising potential applications. We demonstrate here the as-synthesized vertically standing MoS2 nanosheets could be used for hydrogen evolution reaction, where the exchange current density is about 70 times of bulk MoS2. The field emission performance of vertically standing MoS2 were also improved due to the abundantly exposed edges.
On pushing the outer edge of the outer edge of paclitaxel's dosing envelope. (1999)

Thomas Wolfe’s account of the space program The Right Stuff [(1)][1] describes how raw human spirit and determination enabled what would be considered a rather primitive technology, at least by today’s standards, to “push the outer edge of the envelope,” achieving the seemingly unachievable
Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma (2006)

A single center, prospective clinical trial was conducted evaluating 2 cycles of induction high-dose chemotherapy for adults younger than 65 years of age with aggressive non-Hodgkin lymphoma (NHL) and 2 to 3 Age-Adjusted International Prognostic Index risk factors. Patients received one cycle of standard dose cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) followed by one cycle of dose-intensive cyclophosphamide 5.25 g/m(2), etoposide 1.05 g/m(2), cisplatin 105 mg/m(2) (DICEP), then underwent autologous blood stem cell collection, followed by one cycle of high-dose carmustine (BCNU) 300 mg/m(2), etoposide 800 mg/m(2), Ara-C 1600 mg/m(2), melphalan 140 mg/m(2) (BEAM), and autologous stem cell transplantation (ASCT) and radiotherapy to prior bulk. From June 1998 to August 2004, 55 patients aged 20 to 63 years (median 44 years) were accrued, 51 (92%) of whom had diffuse large B-cell NHL. Poor prognostic factors included stage 4 (n = 46), elevated lactate dehydrogenase (LDH; n = 47), Eastern Cooperative Oncology Group (ECOG) performance status 2 to 4 (n = 43), bulky mass more than 10 cm (n = 34), and marrow involvement (n = 16). Only one patient experienced nonrelapse mortality. With a median follow-up of 49 months, 4-year event-free survival (EFS) and overall survival (OS) rates for all 55 patients are 72% (95% confidence interval [CI] = 60%-84%) and 79% (95% CI = 69%-90%), respectively. In conclusion, CHOP-DICEP-BEAM is feasible and gave encouraging EFS and OS for patients with poor-prognosis aggressive NHL.
Property Improvement of 75 nm-thick Directly-crystallized SrBi<sub>2</sub>Ta<sub>2</sub>O<sub>9</sub> Thin Films by Pulse-introduced Metalorganic Chemical Vapor Deposition at Low Temperature (2001)

Crystallized SrBi 2 Ta 2 O 9 (SBT) films were deposited on (111) Ir/TiO 2 /SiO 2 /Si substrates at 650°C by metalorganic chemical vapor deposition (MOCVD). Crystallized SBT films from 75 to 200 nm in thickness were directly deposited, but its remanent polarization (Pr) decreased when the film thickness decreased for the film deposited by conventional continuous-MOCVD. This Pr value was increased by 50% by using the source gas pulse-introduction technique (pulse-MOCVD) at 75 nm thicknesses. Moreover, the leakage current was dramatically improved to be on the order of 10 -5 A/cm 2 up to 600 kV/cm. This film exhibited strong (103) orientation of the crystal axis, while the continuous gas-introduced film showed a mixture of (00 l ) and (103) orientations.
SMPTE Tutorial Paper: Noise in Film-to-Video Transfers (1987)

Factors affecting noise in film-to-video transfers are discussed. Two primary sources of noise are identified: noise associated with film granularity and electronic noise. The influence of various film stocks on noise (such as negative films and positive films) and the effects of telecine controls on noise are described. Comparisons are also made between specific characteristics of 16 mm and 35 mm film stocks.
Human following robot based on control of particle distribution with integrated range sensors (2011)

In this study, a human-following robot based on a laser range scanner and a Kinect sensor is developed for tracking and identifying target human. Most of tracking systems with laser range scanners have the problems of occlusions and the harmful effects of noise. Generally, human tracking systems utilize particle filter to solve those problems. However, if there are several people in the measurement range of laser scanners, particles are sometimes distributed to only a certain human. With a particle filter based on control of particle distribution and with integrated sensors between LRF and Kinect, this study aims to identify the target human and achieve human-following behavior by the robot Tracking experiments of several people and human-following experiments were performed, and some results are provided in the paper.
Sequencing the storages and retrievals for flow-rack automated storage and retrieval systems with duration-of-stay storage policy (2015)

Sequencing of storages and retrievals is an important topic in the automated storage and retrieval system (AS/RS), which largely influences the throughput performance and the operational cost of an AS/RS. In this paper, the problem of sequencing the storages and retrievals in a flow-rack AS/RS with duration-of-stay storage policy is analysed and a two-step heuristic called the grouping-matching method is proposed for minimising the total travel time of operations. The proposed grouping-matching method assigns unit-loads into groups in the grouping step and matches groups and bins of flow rack in the matching step. Two grouping heuristics are designed for the grouping step. The matching subproblem is formulated as an assignment to be solved. Simulation experiments are conducted to evaluate the effectiveness and efficiency of the grouping-matching method and the two grouping heuristics used for the grouping subproblem.
Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis (2008)

There is abundant evidence that Retinoblastoma (Rb) activity is important in the control of cell proliferation and apoptosis. Reversible phosphorylation of the Rb protein that is carried out by cyclin dependent kinases and Protein phosphatase 1 (PP1) regulates its functions. A PP1 interacting protein, PNUTS (Phosphatase Nuclear Targeting Subunit) is proposed to be a regulator of Rb phosphorylation. In this study, PNUTS knockdown in MCF7, SKA and HCT116 cancer cells causes a reduction in viability due to increased apoptosis. However, normal cells (MCF10A breast and CCD-18Co colon) do not exhibit reduced viability when PNUTS expression is diminished. PNUTS knockdown has no effect in Rb-null Saos-2 cells. However, when Rb is stably expressed in Saos-2 cells, PNUTS knockdown reduces cell number. Knockdown of PNUTS in p53-/- HCT116 cells indicates that p53 is dispensable for the induction of apoptosis. Loss of PNUTS expression results in increased Rb-phosphatase activity and Rb dephosphorylation. E2F1 dissociates from Rb in cells depleted of PNUTS and the resulting apoptosis is dependent on caspase-8. These results indicate that Rb phosphorylation state can be manipulated by targeting Rb phosphatase activity and suggest that PNUTS may be a potential target for therapeutic pro-apoptotic strategies.