gebhart/patrepeval huggingface dataset:
In vitro transcription of the inverted terminal repetition of the vaccinia virus genome: correspondence of initiation and cap sites (1981)

Specific RNAs synthesized in vitro by vaccinia virus cores were analyzed with the aid of DNA from the terminal 9,000 base pairs of the genome that was cloned in phage lambda, pBR322, and the single-stranded phage fl. Three mRNA's coding for polypeptides with molecular weights of 7,500 (7.5K), 19K, and 42K were shown to have sizes and map positions similar to those described for mRNA's made early in infection. A previously undescribed transcript made in vivo and in vitro, with a 5' end at about 8.7 kilobase pairs from the end of the genome, was also detected. After chemical removal of the terminal 7-methylguanosine residue, the 5' ends of the RNAs were specifically labeled by enzymatic capping and the mapped by gel electrophoresis of nuclease-resistant RNA.DNA hybrids, as well as by hybridization of the end-labeled RNA to immobilized DNA restriction fragments. Analysis of the purified cap structures demonstrated that three of the mRNA's have both m7G(5')pppAm and, m7G(5')pppGm ends, indicating some degree of terminal heterogeneity. The fourth transcript has exclusively m7G(5')pppAm ends. By synthesizing RNA in the presence of [beta-32P]GTP, it could be shown that cap sites correspond to sites of initiation of RNA synthesis.
FMHash: Deep Hashing of In-Air-Handwriting for User Identification (2018)

Many mobile systems and wearable devices, such as Virtual Reality (VR) or Augmented Reality (AR) headsets, lack a keyboard or touchscreen to type an ID and password for signing into a virtual website. However, they are usually equipped with gesture capture interfaces to allow the user to interact with the system directly with hand gestures. Although gesture-based authentication has been well-studied, less attention is paid to the gesture-based user identification problem, which is essentially an input method of account ID and an efficient searching and indexing method of a database of gesture signals. In this paper, we propose FMHash (i.e., Finger Motion Hash), a user identification framework that can generate a compact binary hash code from a piece of in-air-handwriting of an ID string. This hash code enables indexing and fast search of a large account database using the in-air-handwriting by a hash table. To demonstrate the effectiveness of the framework, we implemented a prototype and achieved >99.5% precision and >92.6% recall with exact hash code match on a dataset of 200 accounts collected by us. The ability of hashing in-air-handwriting pattern to binary code can be used to achieve convenient sign-in and sign-up with in-air-handwriting gesture ID on future mobile and wearable systems connected to the Internet.
ATR-Vis (2018)

The worldwide adoption of Twitter turned it into one of the most popular platforms for content analysis as it serves as a gauge of the public’s feeling and opinion on a variety of topics. This is particularly true of political discussions and lawmakers’ actions and initiatives. Yet, one common but unrealistic assumption is that the data of interest for analysis is readily available in a comprehensive and accurate form. Data need to be retrieved, but due to the brevity and noisy nature of Twitter content, it is difficult to formulate user queries that match relevant posts that use different terminology without introducing a considerable volume of unwanted content. This problem is aggravated when the analysis must contemplate multiple and related topics of interest, for which comments are being concurrently posted. This article presents Active Tweet Retrieval Visualization (ATR-Vis), a user-driven visual approach for the retrieval of Twitter content applicable to this scenario. The method proposes a set of active retrieval strategies to involve an analyst in such a way that a major improvement in retrieval coverage and precision is attained with minimal user effort. ATR-Vis enables non-technical users to benefit from the aforementioned active learning strategies by providing visual aids to facilitate the requested supervision. This supports the exploration of the space of potentially relevant tweets, and affords a better understanding of the retrieval results. We evaluate our approach in scenarios in which the task is to retrieve tweets related to multiple parliamentary debates within a specific time span. We collected two Twitter datasets, one associated with debates in the Canadian House of Commons during a particular week in May 2014, and another associated with debates in the Brazilian Federal Senate during a selected week in May 2015. The two use cases illustrate the effectiveness of ATR-Vis for the retrieval of relevant tweets, while quantitative results show that our approach achieves high retrieval quality with a modest amount of supervision. Finally, we evaluated our tool with three external users who perform searching in social media as part of their professional work.
Herb Yield and Bacoside-A Content of Field-Grown<i>Bacopa monnieri</i>Accessions (2002)

ABSTRACT A field trial of five accessions of Bacopa monnieri (L.) Pennell was conducted during 1997 to 1998, at Lucknow, India, to standardize cultivation procedures for domestication of this medicinal herb. The accessions, monitored for growth and bacoside-A yields over 18 months, could be maintained as perennials, but growth properties were sensitive to the growing season. Loss of shoot biomass occurred in winter (December-February) and the growth rate was higher in the monsoon season (July-September) than in summer (March-June). Bacoside-A content of herb was high from September through March and in June. Suitable harvest times for high yields of bacoside-A were June and September through November. An accession from Guwahati in Assam state of India yielded more bacoside-A than all other accessions.
Maritime Electrical Installations And Diesel Electric Propulsion (2003)

This tutorial report is written in order to give an overview of application and solutions, as well as an introduction to components used in vessels with electric propulsion. The note is aimed to be a reference for those needing an update on recent solutions, and as a tutorial for new personnel in this exiting and fast developing area. Although it is tried to keep information updated and as far as possible free of errors, it is to be noted that the author or ABB cannot be held responsible for any faults or failures resulting from use of this content. Neither can this note be used as a contractually binding document for ABB in any commercial or other relations, regardless of referred to in writing or orally by other documents.
Structure determination from powder diffraction data of a new layered ammonium lanthanum sulfate, β-(NH <sub>4</sub> )La(SO <sub>4</sub> ) <sub>2</sub> (2002)

A new variety of ammonium lanthanum sulfate, β-(NH 4 )La(SO 4 ) 2 , was synthesized hydrothermally. The crystal structure was solved ab initio from powder diffraction data collected using a conventional X-ray source. The powder diffraction pattern was indexed by the successive dichotomy method: The symmetry is monoclinic, space group Pn , cell dimensions a =6.9365(4) Å, b =9.0055(5) Å, c =5.4541(4) Å, β=90.672(8)°, V =340.68(3) Å 3 and Z =2 [M 20 =65, F 30 =124(0.0071,34)]. Direct methods were used for structure solution, and refinement of the atomic coordinates was carried out by the Rietveld method ( R F =0.061, R wp =0.099). The structure contains anionic layers built from lanthanum atoms ninefold coordinated to monodentate and bidentate sulfate oxygen atoms. Ammonium groups, which provide hydrogen bonds, are located between the layers. The crystal structure contrasts with that of the α phase, which is less dense by a factor of 4.4%.
The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex (2015)

The MAGE (Melanoma-associated antigen) protein family members are structurally related to each other by a MAGE-homology domain comprised of 2 winged helix motifs WH/A and WH/B. This family specifically evolved in placental mammals although single homologs designated NSE3 (non-SMC element) exist in most eukaryotes. NSE3, together with its partner proteins NSE1 and NSE4 form a tight subcomplex of the structural maintenance of chromosomes SMC5-6 complex. Previously, we showed that interactions of the WH/B motif of the MAGE proteins with their NSE4/EID partners are evolutionarily conserved (including the MAGEA1-NSE4 interaction). In contrast, the interaction of the WH/A motif of NSE3 with NSE1 diverged in the MAGE paralogs. We hypothesized that the MAGE paralogs acquired new RING-finger-containing partners through their evolution and form MAGE complexes reminiscent of NSE1-NSE3-NSE4 trimers. In this work, we employed the yeast 2-hybrid system to screen a human RING-finger protein library against several MAGE baits. We identified a number of potential MAGE-RING interactions and confirmed several of them (MDM4, PCGF6, RNF166, TRAF6, TRIM8, TRIM31, TRIM41) in co-immunoprecipitation experiments. Among these MAGE-RING pairs, we chose to examine MAGEA1-TRIM31 in detail and showed that both WH/A and WH/B motifs of MAGEA1 bind to the coiled-coil domain of TRIM31 and that MAGEA1 interaction stimulates TRIM31 ubiquitin-ligase activity. In addition, TRIM31 directly binds to NSE4, suggesting the existence of a TRIM31-MAGEA1-NSE4 complex reminiscent of the NSE1-NSE3-NSE4 trimer. These results suggest that MAGEA1 functions as a co-factor of TRIM31 ubiquitin-ligase and that the TRIM31-MAGEA1-NSE4 complex may have evolved from an ancestral NSE1-NSE3-NSE4 complex.
Laser-induced photodissociation of carboxyhemoglobin: An optical method for eliminating the toxic effect of carbon monoxide (2010)

We propose and examine an optical method for eliminating the toxic effect of carbon monoxide. The developed method is based on laser-induced photodissociation of carboxyhemoglobin in blood vessels and capillaries. By numerical simulation of the interaction of laser radiation with tissue, we calculate the spectra of the action of carboxyhemoglobin and oxyhemoglobin in cutaneous blood vessels. We show that, despite the sufficiently strong overlap of the action spectra of carboxyhemoglobin and oxyhemoglobin, the substantial difference in the quantum yield values makes it possible to develop an optical method for eliminating the toxic effect of carbon monoxide. We determine the criteria for the efficiency of laser-induced photodissociation of carboxyhemoglobin under direct action on lung alveoli through the skin tissue and intravenously.
Paraphrase recognition via dissimilarity significance classification (2006)

We propose a supervised, two-phase framework to address the problem of paraphrase recognition (PR). Unlike most PR systems that focus on sentence similarity, our framework detects dissimilarities between sentences and makes its paraphrase judgment based on the significance of such dissimilarities. The ability to differentiate significant dissimilarities not only reveals what makes two sentences a non-paraphrase, but also helps to recall additional paraphrases that contain extra but insignificant information. Experimental results show that while being accurate at discerning non-paraphrasing dissimilarities, our implemented system is able to achieve higher paraphrase recall (93%), at an overall performance comparable to the alternatives.
All-Optical NRZ-to-PRZ Converter at 10 Gb/s Based on Self-Phase Modulation of Fabry–PÉrot Laser Diode (2004)

We propose and demonstrate nonreturn-to-zero (NRZ) to pseudoreturn-to-zero (PRZ) data format conversion at 10 Gb/s based on transverse-magnetic (TM) mode absorption and self-phase modulation (SPM) in a Fabry-Pe/spl acute/rot laser diode (FP-LD). An FP-LD has absorption nulls for TM mode injected beam and the beam having NRZ data experiences SPM, which induces a frequency chirp at every rising edge and falling edge. By extracting the chirp components, all-optical NRZ-to-PRZ format conversion has been achieved. The resultant PRZ data gives well-defined 10-Gb/s clock signal. This method will be very useful in all-optical clock recovery of high-speed optical communication systems.
<i>In vivo</i> effect of inactivation of ribosome recycling factor – fate of ribosomes after unscheduled translation downstream of open reading frame (2004)

The post-termination ribosomal complex is disassembled by ribosome recycling factor (RRF) and elongation factor G. Without RRF, the ribosome is not released from mRNA at the termination codon and reinitiates translation downstream. This is called unscheduled translation. Here, we show that at the non-permissive temperature of a temperature-sensitive RRF strain, RRF is lost quickly, and some ribosomes reach the 3' end of mRNA. However, instead of accumulating at the 3' end of mRNA, ribosomes are released as monosomes. Some ribosomes are transferred to transfer-messenger RNA from the 3' end of mRNA. The monosomes thus produced are able to translate synthetic homopolymer but not natural mRNA with leader and canonical initiation signal. The pellet containing ribosomes appears to be responsible for rapid but reversible inhibition of most but not all of protein synthesis in vivo closely followed by decrease of cellular RNA and DNA synthesis.
Antiplaque and Antigingivitis Toothpastes (2013)

Dentifrices are a general term used to describe preparations that are used together with a toothbrush with the purpose to clean and/or polish the teeth. Active toothpastes were first formulated in the 1950s and included ingredients such as urea, enzymes, ammonium phosphate, sodium lauryl sarcosinate and stannous fluoride. Later, therapeutic agents were included. Today's toothpastes have two objectives: to help the toothbrush in cleaning the tooth surface and to provide a therapeutic effect. The therapeutic effect may have an antiplaque or anti-inflammatory basis when the nature of the agents is antimicrobial. Plaque inhibitory and antiplaque activity of toothpastes used for chemical plaque control is evaluated in distinct consecutive stages, the last being home use randomized clinical trials of at least 6 months' duration. In this chapter, the scientific evidence supporting the use of the most common antiplaque agents, included in toothpaste formulations, is reviewed, with a special emphasis on 6-month clinical trials, and systematic reviews with meta-analyses of the mentioned studies. Among the active agents, the following have been included in toothpastes: enzymes, amine alcohols, herbal or natural products, triclosan, bisbiguanides (chlorhexidine), quaternary ammonium compounds (cetylpyridinium chloride) and different metal salts (zinc salts, stannous fluoride, stannous fluoride with amine fluoride). Dentifrices are the ideal vehicles for any active ingredient used as an oral health preventive measure since they are used in combination with toothbrushing, which is the most frequently employed oral hygiene method. The most important indications of dentifrices with active ingredients are associated with long-term use to prevent bacterial biofilm formation, mostly in gingivitis patients or in patients on supportive periodontal therapy.
Nanocrystalline Nanowires:  2. Phonons (2006)

Nanocrystalline nanowires (NCNW) are fragments of bulk crystals that are infinite in only one direction. A construction is given for calculating eigenstates belonging to the symmetry labels (k,m) (wavevector and rotational quantum number). Vibrational harmonic eigenstates are worked out explicitly for a simple model, illustrating the general results: the LA mode has m=0, while with sufficient rotational symmetry, the TA branch is doubly degenerate, has m=+/-1, and has quadratic dispersion with k for k less than the reciprocal diameter of the NCNW. The twiston branch (a fourth Goldstone boson) is an acoustic m=0 branch, additional to the LA and two TA branches.
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity (2021)

SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is a highly variable region of S and provide epidemiological, clinical, and molecular characterization of a prevalent, sentinel RBM mutation, N439K. We demonstrate N439K S protein has enhanced binding affinity to the hACE2 receptor, and N439K viruses have similar in vitro replication fitness and cause infections with similar clinical outcomes as compared to wild type. We show the N439K mutation confers resistance against several neutralizing monoclonal antibodies, including one authorized for emergency use by the US Food and Drug Administration (FDA), and reduces the activity of some polyclonal sera from persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics.
A Review of SOI Technology and its Applications (2020)

Classical scaling is no longer possible to follow Moore’s law. In addition to the material innovations such as high K/metal gate and stressors, a transition to SOI is essential to meet scaling and performancerequirements alike. The advances in SOI for fully depleted devices and some key SOI applications are described.
In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE (1999)

To investigate the quantitative requirement for apolipoprotein (apo) E in the clearance of lipoproteins via the non-low density lipoprotein (LDL) receptor mediated pathway, human APOE was overexpressed at various levels in the livers of mice deficient for both the endogenous Apoe and Ldlr genes (Apoe -/-. Ldlr -/-) using adenovirus-mediated gene transfer. We found that a low level of APOE expression, that was capable of reducing the hyperlipidemia in Apoe -/- mice, did not result in a reduction of the hyperlipidemia in Apoe -/-. Ldlr -/- mice. Surpisingly, a very high level of APOE expression also did not result in a reduction of hypercholesterolemia in Apoe -/-. Ldlr -/- mice, despite very high levels of circulating apoE (>160 mg/dl). Only a moderately high level of APOE expression resulted in a reduction of serum cholesterol level (from 35.2 +/- 6.7 to 14.6 +/- 2.3 mmol/l) and the disappearance of VLDL from the serum. Moreover, the very high level of APOE expression resulted in a severe hypertriglyceridemia in Apoe -/-. Ldlr -/- mice and not Apoe -/- mice (25.7 +/- 8.9 and 2.2 +/- 1.8 mmol/l, respectively). This hypertriglyceridemia was associated with an APOE-induced increase in the VLDL triglyceride production rate and an inhibition of VLDL-triglyceride lipolysis. We conclude from these data that, for efficient clearance, the non-LDL receptor-mediated pathway requires a higher level of APOE expression as compared to the LDL receptor, but is more sensitive to an APOE-induced increase in VLDL production and inhibition of VLDL-triglyceride lipolysis.-van Dijk, K. W., B. J. M. Van Vlijmen, H. B. van't Hof, A. van der Zee, S. Santamarina-Fojo, T. J. C. van Berkel, L. M. Havekes, and M. H. Hofker. In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess APOE.
Low-delay communication for Rayleigh fading channels: an application of the multiple description quantizer (1995)

We show the multiple description scalar quantizer (MDSQ), when used over a slow fading Rayleigh channel, results in a smaller interleaving delay than traditional channel code-based approaches and substantially outperforms a system using a maximum ratio combiner. We consider a continuous alphabet source without memory over a slow Rayleigh fading channel. Specifically, it is initially assumed that the Rayleigh parameter remains constant over a specific time interval and the demodulator has available perfect estimates of the Rayleigh parameter. An analysis of the problem is presented and theoretical justification is provided for using the MDSQ. For a Gaussian source without memory, performance comparisons are presented against a traditional maximum ratio combiner (MRC)-based system as well as against channel code-based systems. It is shown that the performance of the MDSQ-based system dominates the MRC-based system at all channel signal-to-noise ratios and is superior to channel code-based systems when the interleaving delay is constrained. Simulation results for a mobile radio channel model at 15 m.p.h. indicate a reduction in the interleaving delay by at least a factor of three.
Introduction to Radar Systems (1999)

1 An Introduction to Radar 2 The Radar Equation 3 MTI and Pulse Doppler Radar 4 Tracking Radar 5 Detection of Signals in Noise 6 Information from Radar Signals 7 Radar Clutter 8 Propogation of Radar Waves 9 The Radar Antenna 10 Radar Transmitters 11 Radar Receiver
Automated 3-D montage synthesis from laser-scanning confocal images: Application to quantitative tissue-level cytological analysis (1996)

This paper presents a landmark based method for efficient, robust, and automated computational synthesis of high-resolution, two-dimensional (2-D) or three-dimensional (3-D) wide-area images of a specimen from a series of overlapping partial views. The synthesized image is the set union of the areas or volumes covered by the partial views, and is called the "montage." This technique is used not only to produce gray-level montages, but also to montage the results of automated image analysis, such as 3-D cell segmentation and counting, so as to generate large representations that are equivalent to processing the large wide-area image at high resolution. The method is based on computing a concise set of feature-tagged landmarks in each partial view, and establishing correspondences between the landmarks using a combinatorial point matching algorithm. This algorithm yields a spatial transformation linking the partial views that can be used to create the montage. Such processing can be a first step towards high-resolution large-scale quantitative tissue studies. A detailed example using 3-D laser-scanning confocal microscope images of acriflavine-stained hippocampal sections of rat brain is presented to illustrate the method.
Pneumothorax: appearance on lateral chest radiographs. (1989)

The appearance of pneumothorax on lateral radiographs obtained with the patient erect were reviewed in 100 patients (122 total examinations). A pneumothorax could be seen on the lateral projection in 89% of the examinations (109 of 122). The displaced pleural line was most frequently identified anteriorly or posteriorly and was less commonly identified at the lung apex or in a subpulmonic location. In 11 cases, an air-fluid level was the only recognizable finding of a pneumothorax on the lateral projection. Although in 27% of examinations (32 of 122) the pneumothorax was either not seen (11%) (n = 13) or was a subtle finding (16%) (n = 19), in 14% of examinations (17 of 122) the lateral projection provided helpful information to supplement the posteroanterior projection.