gebhart/patrepeval huggingface dataset:
SHORTVEIN, A NEW COMPONENT OF THE DECAPENTAPLEGIC GENE COMPLEX IN <i>DROSOPHILA MELANOGASTER</i> (1985)

Our laboratory has been concerned with the structure and function of the decapentaplegic gene complex (DPP-C) in Drosophila melanogaster. To define the boundaries of the complex, we have studied the genetics of mutations allelic to a previously discovered mutation shortvein (shv), known to reside near decapentaplegic. We found that shortvein resides distal to Hin-d and dpp within the same polytene chromosome doublet, 22F1-2. Lesions in shv can affect not only the formation of the wing veins but also can interfere with normal development of parts of the adult and/or be lethal. Like those of dpp mutants, the shv-associated adult abnormalities affect distal epidermal structures. Some shv lesions cause a larval lethal syndrome which is associated with an unusually long larval stage (ca. five to six times its normal duration). Lesions in shv exhibit an involved pattern of complementation with dpp mutations, indicating that both shv and dpp are parts of a single gene complex. A subset of the array of mutant phenotypes displayed by shv/dpp trans-heterozygotes appear to be dpp-specific phenotypes; we interpret these as reflecting an inactivation effect of certain shv alleles on dpp functions. The other abnormalities displayed by these trans-heterozygotes appear to be shv-specific defects; we view these as indicating an inactivation effect of certain dpp mutations on shv functions. Furthermore, embryonic lethal (EL) mutations within the DPP-C exhibit allelic interactions with all shv mutations. We conclude that the shortvein region represents a newly identified integrated portion of the DPP-C.
A Nanoengineering Approach for Investigation and Regulation of Protein Immobilization (2008)

It is known that protein attachment to surfaces depends sensitively upon the local structure and environment of the binding sites at the nanometer scale. Using nanografting and reversal nanografting, both atomic force microscopy (AFM)-based lithography techniques, protein binding sites with well-defined local environments are designed and engineered with nanometer precision. Three proteins, goat antibiotin immunoglobulin G (IgG), lysozyme, and rabbit immunoglobulin G, are immobilized onto these engineered surfaces. Strong dependence on the dimension and spatial distribution of protein binding sites are revealed in antibody recognition, covalent attachment via primary amine residues and surface-bound aldehyde groups. This investigation indicates that AFM-based nanolithography enables the production of protein nanostructures, and more importantly, protein-surface interactions at a molecular level can be regulated by changing the binding domains and their local environment at nanometer scale.
Electron and Hole Dynamics on Isolated Chains of a Solution‐Processable Poly(thienylenevinylene) Derivative in Dilute Solution (2005)

Intrachain dynamics of charge carriers on isolated chains of a derivative of the π-conjugated polymer, poly(thienylenevinylene) (see Figure), in solution are investigated using time-resolved microwave conductivity measurements. High intrachain mobilities, of 0.23 ± 0.04 and 0.38 ± 0.02 cm2 V–1 s–1, are found for electrons and holes, respectively. It is observed that electrons become trapped at defects or impurities, in contrast to holes.
Response of Human Prostate Cancer Cells and Tumors to Combining PARP Inhibition with Ionizing Radiation (2011)

Radiation therapy remains a promising modality for curative treatment of localized prostate cancer, but dose-limiting toxicities significantly limit its effectiveness. Agents that enhance efficacy at lower radiation doses might have considerable value in increasing tumor control without compromising organ function. Here, we tested the hypothesis that the PARP inhibitor ABT-888 (veliparib) can enhance the response of prostate cancer cells and tumors to ionizing radiation (IR). Following exposure of DU-145 and PC-3 prostate cancer cell lines to the combination of 10 μmol/L ABT-888 and 6 Gy, we observed similar persistence between both cell lines of DNA damage foci and in vitro radiosensitization. We have previously observed that persistent DNA damage foci formed after ABT-888 plus IR efficiently promote accelerated cell senescence, but only PC-3 cells displayed the expected senescent response of G(2)-M arrest, induction of p21 and β-galactosidase expression, and accumulation as large flat cells. In turn, combining ABT-888 with 6 Gy resulted in delayed tumor regrowth compared with either agent alone only in PC-3 xenograft tumors, whereas DU-145 tumors continued to grow. By 7 days after treatment with ABT-888 plus IR, PC-3 tumors contained abundant senescent cells displaying persistent DNA damage foci, but no evidence of senescence was noted in the DU-145 tumors. That equivalent radiosensitization by ABT-888 plus IR in vitro failed to predict comparable results with tumors in vivo suggests that the efficacy of PARP inhibitors may partially depend on a competent senescence response to accumulated DNA damage.
Improving the lifetime in optical microtraps by using elliptically polarized dipole light (2018)

Tightly focused optical dipole traps induce vector light shifts (``fictitious magnetic fields'') which complicate their use for single-atom trapping and manipulation. The problem can be mitigated by adding a larger, real magnetic field, but this solution is not always applicable; in particular, it precludes fast switching to a field-free configuration. Here we show that this issue can be addressed elegantly by deliberately adding a small elliptical polarization component to the dipole trap beam. In our experiments with single $^{87}\mathrm{Rb}$ atoms laser-cooled in a chopped trap, we observe improvements up to a factor of 11 of the trap lifetime compared to the standard, seemingly ideal linear polarization. This effect results from a modification of heating processes via spin-state diffusion in state-dependent trapping potentials. We develop Monte Carlo simulations of the evolution of the atom's internal and motional states and find that they agree quantitatively with the experimental data. The method is general and can be applied in all experiments where the longitudinal polarization component is non-negligible.
Joint coding of multi-view video and corresponding depth map (2008)

In this paper, we propose a joint coding scheme for both multi-view video and its corresponding depth map. After we synthesize a virtual image for the target view using adjacent view images and their depth information, we apply a view interpolation prediction (VIP) method for both multi-view video coding and its depth data coding. In order to improve the synthesized virtual view, we also propose a hole filling method that can compensate for empty regions caused by the 3D warping operation. With the proposed algorithm, we have obtained approximately 0.65 dB of the PSNR gain on average for the multi-view depth data, and 0.17 dB of the PSNR gain for the multi-view video data, compared to JMVM 1.0.
Interaction of tri-tert-butylgallium with elemental sulfur, selenium, and tellurium (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of tri-tert-butylgallium with elemental sulfur, selenium, and telluriumMichael B. Power, Joseph W. Ziller, Andrew N. Tyler, and Andrew R. BarronCite this: Organometallics 1992, 11, 3, 1055–1063Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/om00039a010https://doi.org/10.1021/om00039a010research-articleACS PublicationsRequest reuse permissionsArticle Views244Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Expression and Functional Analysis of Water Channels in a Stably AQP2-transfected Human Collecting Duct Cell Line (1996)

In this study, we describe the establishment of a stably transfected epithelial cell line with the cDNA for the rat aquaporin 2 (AQP2). To this end, we used a human cell line (HCD) derived from the cortical collecting duct and having characteristics of principal cells (Prié, D., Friedlander, G., Coureau, C., Vandewalle, A., Cassigena, R., and Ronco, P. M. (1995) Kidney Int. 47, 1310-1318). The HCD cells were first screened for the constitutive expression of AQPs. By Western blot analysis, we found a low expression of immunoreactive AQP2 and AQP4 proteins. In contrast, transfected cells (clone CD8) probed with AQP2 antiserum expressed an intense 29-kDa protein on immunoblot in addition to a broad band between 35-45 kDa corresponding to the glycosylated form of the protein, indicating that full maturity of the protein is attained in transfected cells. Immunofluorescence demonstrated that AQP2 was located in intracellular vesicles. After vasopressin stimulation, the staining redistributed from an intracellular site to the apical pole of the cells, an effect similar to that described on collecting duct principal cells in vivo (Sabolic, I., Katsura, T., Verbavatz, J. M., and Brown, D. (1995) J. Membr. Biol. 143, 165-175) and in perfused tubules (Nielsen, S., Chou, C. L., Marples, D., Christensen, E. I., Kishore, B. K., and Knepper, M. A. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1013-1017). The redistribution of AQP2 in CD8 cells was accompanied by an approximately 6-fold increase in osmotic water permeability coefficient (Pf), which was inhibited by 0.3 m HgCl2. These data indicate that functional vasopressin-sensitive water channels are expressed in transfected cells. The stably transfected cells represent a suitable model to unravel by direct experimental approach the intracellular signals involved in the translocation of AQP2 to the apical plasma membrane in the presence of vasopressin.
HOPE--a novel tool for the pathologist. (2005)

The growing demand for the detection of prognostic and diagnostic biomarkers by application of molecular-biological techniques has been slowed down to a large degree by the use of formalin and its influence onto antigenic structures and nucleic acids, although other reasons also exist. With regard to morphology a limitation in the possibilities, compared to frozen sections, takes place. With the introduction of the HOPE (Hepes glutamic acid buffer mediated Organic solvent Protection Effect) -fixation to date both have become possible; substantially enlarged possibilities concerning the detection of DNA, RNA and proteins in combination with excellent morphological results comparable to formalin-fixed tissues. We also highlight some aspects from our lung specific work during the last years. Immunohistochemical markers for differential diagnostics of malignancies in the lungs are discussed; their enhanced detectability using the HOPE-technique is pathbreaking for the future. The same holds true for the substantially enhanced detectability of germs (e.g. mycobacteria) in HOPE-fixed tissues.
Facile and rapid ruthenium mediated photo-crosslinking of Bombyx mori silk fibroin (2014)

A facile and rapid ruthenium catalysed photo-crosslinking method was employed to prepare Bombyx mori silk fibroin hydrogels for the first time that may be used for biomedical applications. The gels have been characterised by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), photo-acoustic Fourier transform infrared spectroscopy (PA-FTIR), and X-ray diffraction (XRD). We have reported the tuning of the properties of the chemically crosslinked gels through hydration level. DSC and DMA measurements have shown that the molecular chain dynamics and mechanical properties are dependent on the moisture/water content. The structural changes upon gelation were examined through the use of DSC, PA-FTIR and XRD, which confirmed that the gels were less crystalline than the original silk powder. Finally, the biocompatibility and hence, the potential tissue engineering application of the silk fibroin hydrogel was also assessed by culturing chondrocyte progenitor cells for up to one week on the engineered fibroin surfaces.
A technique for microwave ranging and remote phase synchronization (2002)

A very precise electrical-distance measurement system that is also capable of supplying a phase-synchronous signal to a remote location is required for a new type of radio telescope, the large adaptive reflector (LAR). The system is based on a round-trip phase synchronization method, and is designed to work over a free-space path of length up to 1 km, the focal distance of the telescope. The electrical length of this path is to be measured with an accuracy of 70 /spl mu/m and a phase-stable signal is to be provided at the remote end as the basis for a local-oscillator signal of stability equivalent to 5/spl deg/ at 22 GHz. Phase synchronization and distance measurement are accomplished with the same microwave ranging circuit. The distance measurement is derived from phase comparison of high-frequency signals, including a novel use of the Chinese Remainder Theorem (CRT) to resolve the unavoidable wavelength ambiguity. The design of the system is described, and limitations imposed by phase-measurement and frequency-setting accuracy are explored. Errors due to atmospheric dispersion are negligible under most circumstances. Accurate phase synchronization has been demonstrated over a free-space path of /spl sim/300 m. The complete system has been simulated under noisy conditions, and its ability to meet the specifications demonstrated.
Scaling laws for linear controllers of flexible link manipulators characterized by nondimensional groups (1997)

When constructing large robotic manipulators or space structures, it is advisable to begin with a small-scale prototype on which to perform the design, analysis, and debugging. To ensure that the results obtained on the scale-model apply directly to the actual manipulator, it is necessary that the prototype and the original robot are dynamically equivalent. This paper examines the single flexible link (SFL) manipulator. Dimensional analysis is used to identify the nondimensional groups for the SFL. These groups are present in the corresponding nondimensional equations of motion, which are also derived. To account for inherent manufacturing imprecision, tolerances are developed for the nondimensional groups. Scaling laws for continuous-time and discrete-time controllers are developed for dynamically equivalent SFL systems. These theoretical scaling laws are verified experimentally for an H/sub /spl infin// and a PD control strategy.
Single event transient propagation through digital optocouplers (2005)

A new approach for assessing the risk of upsetting digital optocouplers due to the propagation of single event transients (SETs) is proposed. The optocoupler's input current (I/sub f/) and propagation time (t/sub pHL/) are found to be the most critical parameters for this approach. A case study using the 6N140 optocoupler and SETs measured at the output of the National Semiconductor LM139 is detailed to validate the concept.
Container Terminal Berth Planning (2009)

A comparative, up-to-date, critical review of existing research efforts relating to berth planning is presented. Existing models are critically reviewed on the basis of their efficiency in addressing key operational and tactical questions relating to vessel service and their relevance and applicability to different marine terminal operator berth-planning strategies and contractual service arrangements between terminal operators and ocean carriers. The strengths and deficiencies of the existing models in addressing real-world problems in a systemic and coherent manner are discussed. The paper concludes with some insights for future research issues.
Aluminum Nitride cross-sectional Lamé mode resonators with 260 MHz lithographic tuning capability and high kt<sup>2</sup> > 4% (2016)

We experimentally demonstrate Aluminum Nitride (AlN) cross-sectional Lamé mode resonators (CLMRs) operating in the microwave frequency range and showing high Qkt <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> products (FoM) in excess of 85. Such feature enables low motional resistance (Rm) values (37 Ω) in CLMRs characterized by low static capacitance (Co) approaching 66 fF. In addition, the ability of CLMRs to simultaneously achieve high kt <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (> 4%) and a lithographic frequency tunability (> 260 MHz around 900 MHz) is experimentally demonstrated, for the first time, in this work. Such important feature renders CLMRs promising candidates to replace off-chip Surface Acoustic Wave (SAW) devices in lithographically defined filters for next-generation wireless communication platforms.
Rise of the Alt-Right (2018)

<JATS1:p>What is the Alt-Right, and how will it affect America?Donald Trump's election as president in 2016 suddenly brought to prominence a political movement that few in political circles or the mainstream media had paid much attention to: the so-called Alt-Right. Steven Bannon, Trump's campaign manager, was a leading figure in the movement, and the election results seemed to give it a real opportunity to gain some political power.But what is the Alt-Right? Is it a movement, a theory, a trend, or just an unorganized group of people far outside of what used to be the political mainstream in America? Or, could it be all of these things? Why has it suddenly emerged into prominence? What impact is it having on American politics today, and what are the prospects for the Alt-Right in the future?Through careful research and analysis,The Rise of the Alt-Rightaddresses these and other questions, tracing the movement's history from the founding of modern conservatism in postwar America to the current Trump era. Although the Alt-Right might seem to be just the latest extremist group to arise in the United States—one likely to take its place in the graveyard of its many predecessors—Thomas J. Main analyzes evidence that the Alt-Right is having a greater influence on the American political mainstream than did past extremist tendencies.The Rise of the Alt-Rightis thus an important study for anyone interested in the future of American politics and public life.</JATS1:p>
One‐pot, facile synthesis of well‐defined molecular brush copolymers by a tandem RAFT and ROMP, “Grafting‐through” strategy (2012)

Two well-defined brush copolymers, PNB-g-PMMA, were synthesized by a one-pot, RAFT/ROMP, “grafting-through” method, without intermediate steps of isolation or purification. The controlled dimensions of the brushes were verified by atomic force microscopy. This strategy significantly simplified the synthesis of brush copolymers when compared with conventional methods.
Hydrogen Infrastructure Challenges and Solutions (2012)

One of the challenges associated with transitioning a transportation economy to any alternative fuel is bringing online fuel production, storage, transportation and end-customer delivery infrastructure at a pace and in the locations relevant to the parallel effort of bringing the related transportation vehicles into the market. In the case of hydrogen as a transportation fuel, the network of fueling stations may include a combination of centralized and de-centralized fuel production. The continuum of centralized to de-centralized production includes massive centralized hydrocarbon fuel processing plants that may number in the tens to hundreds, to neighborhood fueling stations that may number in the tens to hundreds of thousands, to the ultimate de-centralized solution of home fueling stations that may number in the millions. This talk will discuss recent advances in hydrogen fueling demonstrations and lessons learned for the next stage of implementation.
Systematic Review of the Economic Burden of Overt Hepatic Encephalopathy and Pharmacoeconomic Impact of Rifaximin (2018)

In addition to its clinical benefits (e.g. reduction in the risk of recurrence of overt HE, overt HE-related hospitalizations, favourable adverse event profile), economic data are favourable for the use of rifaximin in patients with a history of overt HE.
Sensitivities of large-aperture plasmonic metasurface flat lenses in the long-wave infrared (2018)

Plasmonic metasurface lenses based on polarization conversion are inherently limited in efficiency, and as a result, they have been given sparse attention in favor of higher-performing dielectric variants. However, recent proposals for expanding the design beyond a single interface offer hope for efficient plasmonic structures. Before developing these multi-layer structures, we wish to better understand dependencies of 2D plasmonic designs. Here we demonstrate the spectral, polarization and geometrical sensitivities of nine large-scale variants of the original V-antenna lens design at λ<sub>0</sub> = 8μm. We show that the spectral response oscillates rapidly within a span as small as λ<sub>0</sub>/320, and that strong focusing can occur at both the designed polarization state, and its orthogonal state–and with differing focal distances. Additionally, we determine that the lens performance is only weakly tied to the size of the discretization, offering only marginal improvement as the discretization approaches a continuum.
Urine Monitoring System (2009)

The Urine Monitoring System (UMS) is a system designed to collect an individual crewmember's void, gently separate urine from air, accurately measure void volume, allow for void sample acquisition, and discharge remaining urine into the Waste Collector Subsystem (WCS) onboard the International Space Station. The Urine Monitoring System (UMS) is a successor design to the existing Space Shuttle system and will resolve anomalies such as: liquid carry-over, inaccurate void volume measurements, and cross contamination in void samples. The crew will perform an evaluation of airflow at the ISS UMS urinal hose interface, a calibration evaluation, and a full user interface evaluation. o The UMS can be used to facilitate non-invasive methods for monitoring crew health, evaluation of countermeasures, and implementation of a variety of biomedical research protocols on future exploration missions.