gebhart/patrepeval huggingface dataset:
Numerical study of the turbulent flow past an airfoil with trailing edge separation (1983)

Presentation d'une methode numerique par volume fini pour la resolution des equations de Navier-Stokes bidimensionnelles, incompressibles, et stationnaires, en coordonnees generales curvilignes. Application de la methode aux ecoulements turbulents sur des profils avec et sans separation au bord de sortie posterieur. Comparaison des calculs avec des donnees experimentales
<I>Xenopus</I> Cell-Free Extracts to Study the DNA Damage Response (2004)

Cell-free systems derived from Xenopus eggs represent a powerful tool, intermediate between in vitro and in vivo model systems. Here, we describe protocols to prepare cell-free extracts recapitulating several aspects of the DNA damage response, including the DNA damage-dependent activation of ATM/ATR protein kinases and several DNA damage checkpoint signaling pathways that inhibit initiation of DNA replication. We provide protocols to prepare cell-free extracts, DNA templates, protein kinase substrates, and to perform checkpoint assays. In addition, we describe related methods that provide useful readouts of the DNA damage response.
Photoelectric Conversion Properties of Nanocrystalline TiO<sub>2</sub> Electrodes Sensitized with Hemicyanine Derivatives (2000)

Four hemicyanine derivatives, (E)-N-(3-sulfopropyl-4-[2-(4-dimethylaminophenyl)ethenyl]pyridinium (PS), (E)-N-(3-sulfopropyl-4-[2-(4-dimethylaminophenyl)ethenyl]quinolinium (QS), (E)-N-(3-sulfopropyl-4-[2-(4-N-methyl-N-hexadecylaminophenyl)ethenyl]pyridinium (LPS), and (E)-N-(3-sulfopropyl-4-[2-(4-N-methyl-N-hexadecylaminophenyl)ethenyl]quinolinium (LQS), have been synthesized and characterized with regard to their absorption and electrochemical properties. Photoelectrochemical experiments show that these hemicyanine dyes with D-π-A systems can yield efficient charge separation under illumination of simulated solar light. Alkyl chain has a remarkable effect on dye adsorbance, incident photon-to-electron conversion efficiency, and overall energy conversion yield. The overall yield is approximately doubled when the methyl group replaces the long alkyl chain. Action spectrum of QS displayed a broad feature with 33.8% of maximum monochromatic incident photon-to-electron conversion efficiency (IPCE), and a thin-layer sandwich-type solar cell based on nanocrystalline TiO2 film modified with QS produced about 2% of overall yield. For the first time, a photovoltaic liquid-junction solar cell based on nanostructured TiO2 electrode sensitized by hemicyanine dyes is reported.
Single versus dual venous anastomoses of the free fibula osteocutaneous flap in mandibular reconstruction: A retrospective study (2013)

There is no difference in success rates between single venous anastomosis and dual venous anastomoses for mandibular reconstruction with free fibula osteocutaneous flap.
Synthesis of Electrophore-labeled Oligonucleotides and Characterization by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry (1996)

Recent work to apply mass spectrometric methods to DNA analysis has led to the attachment of an electrophore to an oligonucleotide primer, with the purpose of investigating whether the advantages of electron capture ionization (increased ionization efficiency, reduced fragmentation) could be extended to larger molecules, such as Sanger sequence ladders. The stability of the electrophore-modified primers under conditions encountered during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) was investigated. Four different electrophore labels were successfully attached to the 5' terminus of a 17-base, single-stranded oligodeoxyribonucleotide sequencing primer. The attached electrophore tags are robust under conditions used for sample preparation and MALDI-MS, and little or no fragmentation resulting from loss of the electrophore was observed. While no sensitivity enhancement was observed for the electrophore-labeled DNA, mass spectrometric conditions are discussed under which the electrophore labels could enhance the detection of DNA sequencing ladders.
Shaping of light beams along curves in three dimensions (2013)

We present a method for efficient and versatile generation of beams whose intensity and phase are prescribed along arbitrary 3D curves. It comprises a non-iterative beam shaping technique that does not require solving inversion problems of light propagation. The generated beams have diffraction-limited focusing with high intensity and controlled phase gradients useful for applications such as laser micro-machining and optical trapping. Its performance and feasibility are experimentally demonstrated on several examples including multiple trapping of micron-sized particles.
Electroporation of Xanthomonas (2003)

Species within the genus Xanthomonas demonstrate pathogenesis to a variety of plant types, including rice, crucifers, cotton, wheat, peppers, tomatoes, and geraniums. However, Xanthomonas species do not respond well to chemical treatments that induce competence necessary for transformation studies, and a highly reproducible natural transformation system has yet to be developed. Electrotransformation, a technique by which bacteria are transformed by electroporation, offers an alternative to natural transformation systems (1). Our studies have primarily been concerned with Xanthomonas oryzae pv. oryzae, the causal agent of bacterial leaf blight in rice (2); however, information on other species is included in our discussion.
netDx: interpretable patient classification using integrated patient similarity networks (2019)

Patient classification has widespread biomedical and clinical applications, including diagnosis, prognosis, and treatment response prediction. A clinically useful prediction algorithm should be accurate, generalizable, be able to integrate diverse data types, and handle sparse data. A clinical predictor based on genomic data needs to be interpretable to drive hypothesis-driven research into new treatments. We describe netDx, a novel supervised patient classification framework based on patient similarity networks, which meets these criteria. In a cancer survival benchmark dataset integrating up to six data types in four cancer types, netDx significantly outperforms most other machine-learning approaches across most cancer types. Compared to traditional machine-learning-based patient classifiers, netDx results are more interpretable, visualizing the decision boundary in the context of patient similarity space. When patient similarity is defined by pathway-level gene expression, netDx identifies biological pathways important for outcome prediction, as demonstrated in breast cancer and asthma. netDx can serve as a patient classifier and as a tool for discovery of biological features characteristic of disease. We provide a free software implementation of netDx with automation workflows.
Hollow fibers for delivery of harmonic pulses of Q-switched Nd:YAG lasers (2002)

Flexible hollow fibers for delivery of the second, third, and fourth harmonic pulses of Q-switched Nd:YAG lasers are introduced. For the doubled (532-nm) wavelength, we fabricated a hollow fiber with an internal metal and polymer film by using a silver-mirror plating and a liquid-phase-coating method. For tripled (355-nm) and quadrupled (266-nm) Nd:YAG in the ultraviolet region, we fabricated aluminum hollow fibers with or without an internal polymer layer by using the metal-organic chemical-vapor deposition method. Both types of fiber show high stability for the transmission of high-peak power laser pulses with low transmission losses.
Li<sub>2</sub>PbGeS<sub>4</sub> and Li<sub>2</sub>EuGeS<sub>4</sub>:  Polar Chalcopyrites with a Severe Tetragonal Compression (2001)

Li2PbGeS4 and Li2EuGeS4 form by dissolving Pb/Eu and Ge in molten Li2S9 at 600−650 °C. They crystallize in the tetragonal, noncentrosymmetric space group I-42m with a = 6.5224(5) Å, c = 7.7603(8) Å, Z = 2, R1 = 0.0253, and wR2 = 0.0646 for Li2PbGeS4 and a = 6.5447(4) Å, c = 7.6960(6) Å, Z = 2, R1 = 0.0224, and wR2 = 0.0551 for Li2EuGeS4. These polar compounds possess a compressed chalcopyrite-like structure. The compression occurs along the c axis and results in an expanded coordination sphere for Pb and Eu that can be described as a distorted dodecahedron. The Pb/EuS8 dodecahedra share edges and corners with the GeS4 tetrahedra in such a way as to create small tunnels down the c axis in which the lithium cations reside. The Li+ cations are surrounded by four S2- anions that create a highly distorted tetrahedral pocket. Both compounds are semiconductors with indirect band gaps of 2.41 and 2.54 eV, respectively. We also discuss the results of an LAPW band structure calculation for Li2PbGeS4 and report infrared spectroscopic characterization.
Hairy cell leukemia in two siblings. A human leukocyte antigen-linked disease? (1990)

Shared haplotypes have been documented in three of the four previously reported families with familial hairy cell leukemia (HCL). Human leukocyte antigen (HLA) typing was done on a four-member sibship in which two siblings had hairy cell leukemia. The two affected siblings share the haplotype A2; Bw6, Bw62(15); Cw1; DR4, DRw53; DQw3. No one HLA antigen or haplotype is common among the five families reported at this time. These limited data suggest HCL is not associated with a specific HLA antigen. HLA typing of a larger collection of cases of familial HCL may help better define what role, if any, inheritance plays in the occurrence of this rare disorder among numerous first degree relatives.
Resource Allocation in Hybrid Macro/Femto Networks (2010)

Femtocell has been considered by the wireless industry as a promising solution not only to improve indoor coverage, but also to unload traffic from overburdened macrocell networks. In hybrid macro/femto networks, macrocells may have to share the same spectrum with femtocells, due to spectrum availability and network infrastructure considerations, in spite of potentially excessive interference caused by densely deployed femtocells. In this paper, we propose a decentralized resource allocation scheme for the orthogonal frequency division multiple access (OFDMA) downlink of a shared-spectrum macro/femto network, where each femtocell randomly selects a subset of available OFDMA resources for transmission, in order to achieve decentralized inter-cell interference avoidance. The performance of the decentralized resource allocation scheme is evaluated by simulations based on per-cell or network-wide performance metrics. Simulation results provide insights on how the resource allocation in a shared-spectrum hybrid macro/femto network should take into account the spatial density of femtocells and indoor/outdoor radio propagation channel conditions.
Modeling Dominance in Group Conversations Using Nonverbal Activity Cues (2009)

Dominance - a behavioral expression of power - is a fundamental mechanism of social interaction, expressed and perceived in conversations through spoken words and audiovisual nonverbal cues. The automatic modeling of dominance patterns from sensor data represents a relevant problem in social computing. In this paper, we present a systematic study on dominance modeling in group meetings from fully automatic nonverbal activity cues, in a multi-camera, multi-microphone setting. We investigate efficient audio and visual activity cues for the characterization of dominant behavior, analyzing single and joint modalities. Unsupervised and supervised approaches for dominance modeling are also investigated. Activity cues and models are objectively evaluated on a set of dominance-related classification tasks, derived from an analysis of the variability of human judgment of perceived dominance in group discussions. Our investigation highlights the power of relatively simple yet efficient approaches and the challenges of audiovisual integration. This constitutes the most detailed study on automatic dominance modeling in meetings to date.
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of <i>Streptomyces avermitilis</i> (2006)

A gene cluster encoding all of the enzymes for the biosynthesis of the antibiotic pentalenolactone (1) has recently been identified in Streptomyces avermitilis. The biosynthetic gene cluster contains the ptlI (SAV2999) gene which encodes a cytochrome P450 (CYP183A1). PtlI was cloned by PCR and expressed in Escherichia coli as a C-terminal His6-tag protein. Recombinant PtlI bound pentalenene (3) with high affinity (KD = 1.44 +/- 0.14 muM). Incubation of recombinant PtlI with (+/-)-3 in the presence of NADPH, E. coli flavodoxin and flavodoxin reductase, and O2 resulted in conversion to a single enantiomer of pentalen-13-al (7), by stepwise allylic oxidation via pentalen-13-ol (6). The steady-state kinetic parameters for the oxidation of pentalenene (3) to pentalen-13-ol (6) were kcat = 0.503 +/- 0.006 min-1 and Km = 3.33+/-0.62 muM for 3.
Nanothermoforming of hierarchical optical components utilizing shape memory polymers as active molds (2014)

We utilize shape memory polymers as active mold inserts for the thermoforming of complex, hierarchical nano- and microstructured optical components with undercuts on large scales. Our approach combines nanoimprint/hot embossing and thermoforming with the unique features of shape memory polymers. As examples for this nano- and microthermo-forming process, we demonstrate the fabrication of hierarchical photonic structures inspired by the blue Morpho butterfly as well as diffractive optical elements with nm- and μm-size structures.
Tap-selectable decision feedback equalization (2002)

This paper presents an adaptive tap assignment technique for improving the performance and robustness of a reduced-complexity decision-feedback equalizer (DFE) for broadband wireless mobile communications. The spacing of individual feedforward taps of the DFE is made variable such that, when the channel consists of sparsely-distributed multipath with a large delay spread (e.g., "hilly terrain" delay profiles), the feedforward taps can be sparsely assigned to increase the equalizer span without increasing the total number of the feedforward taps. We provide an analysis of the optimum tap assignment problem and propose a practical channel-estimation-based tap assignment algorithm which can be executed prior to equalizer training. Simulation results are obtained for various outdoor delay profiles with dispersions ranging up to several tens of symbol periods and while using only a small number of feedforward taps (e.g., 5 taps), compared to a conventional contiguous-tap DFE, the proposed tap-selectable DFE is found to give relatively stable performance (measured in terms of required SNR) over all profiles, and also to provide improved robustness to fast fading.
A Feasibility Study on the Use of Equine Chondrogenic Induced Mesenchymal Stem Cells as a Treatment for Natural Occurring Osteoarthritis in Dogs (2019)

Conventional treatments of osteoarthritis (OA) reduce pain and the inflammatory response but do not repair the damaged cartilage. Xenogeneic peripheral blood-derived equine chondrogenically induced mesenchymal stem cells (ciMSC) could thus provide an interesting alternative. Six client-owned dogs with confirmed elbow OA were subjected to a baseline orthopedic examination, pressure plate analysis, general clinical examination, hematological analysis, synovial fluid sampling, and radiographic examination, and their owners completed two surveys. After all examinations, a 0.9% saline solution (placebo control product = CP) was administered intra-articularly. After 6 weeks, all examinations were repeated, owners again completed two surveys, and equine ciMSCs were administered in the same joint. After another 6 weeks, dogs were returned for a final follow-up. No serious adverse events or suspected adverse drug reactions were present during this study. No significant differences in blood analysis were noted between the CP and ciMSC treatment. Two adverse events were observed, both in the same dog, one after CP treatment and one after ciMSC treatment. The owner surveys revealed significantly less pain and lameness after ciMSC treatment compared to after CP treatment. There was no significant difference in the orthopedic examination parameters, the radiographic examination, synovial fluid sampling, and pressure plate analysis between CP treatment and ciMSC treatment. A single intra-articular administration of equine ciMSCs proved to be a well-tolerated treatment, which reduced lameness and pain according to the owner's evaluations compared to a placebo treatment.
Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina. (1993)

This study documents that heparin prevents myocardial infarction better than aspirin during the acute phase of unstable angina.
Histone Deacetylase Inhibitors Suppress TF-κB-dependent Agonist-driven Tissue Factor Expression in Endothelial Cells and Monocytes (2007)

Histone deacetylase inhibitors (HDACi), such as trichostatin A (TSA), can regulate gene expression by promoting acetylation of histones and transcription factors. Human tissue factor (TF) expression is partly governed by a unique, NF-kappaB-related "TF-kappaB" promoter binding site. We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin. TSA and butyrate also blunt TF induction approximately 50% in vitro in peripheral blood mononuclear cells and in vivo in thioglycolate-elicited murine peritoneal macrophages. In human umbilical vein endothelial cells, TSA attenuates by approximately 70% TNF-alpha stimulation of TF mRNA transcription without affecting that of ICAM-1. By electrophoretic mobility shift assay analyses, TNF-alpha and lipopolysaccharide induce strong p65/p50 and p65/c-Rel heterodimer binding to both NF-kappaB and TF-kappaB probes. TSA nearly abolishes TF-kappaB binding without affecting NF-kappaB binding. A chromatin immunoprecipitation assay and a promoter-luciferase reporter system confirm that TSA inhibits TF-kappaB but not NF-kappaB activation. Chromatin immunoprecipitation and small interfering RNA inhibitor studies demonstrate that HDAC3 plays a significant role in TNF-alpha-mediated TF induction. Thus, HDACi transcriptionally inhibit agonist-induced TF expression in endothelial cells and monocytes by a TF-kappaB- and HDAC3-dependent mechanism. We conclude that histone deacetylases, particularly HDAC3, play a hitherto unsuspected role in regulating TF expression and raise the possibility that HDACi might be a novel therapy for thrombotic disorders.
Is tapentadol different from classical opioids? A review of the evidence (2016)

Tapentadol is a single molecule able to deliver analgesia by two distinct mechanisms, a feature which differentiates it from many other analgesics. Pre-clinical data demonstrate two mechanisms of action: mu-opioid receptor agonist activity and noradrenaline re-uptake inhibition. From these, one may predict that tapentadol would be applicable across a broad spectrum of pain from nociceptive to neuropathic. The evidence in animal models suggests that norepinephrine re-uptake inhibition (NRI) is a key mechanism and may even predominate over opioid actions in chronic (and especially neuropathic) pain states, reinforcing that tapentadol is different to classical opioids and may, therefore, be an a priori choice for the treatment of neuropathic and mixed pain. The clinical studies and subsequent practice experience and surveillance support the concept of opioid and non-opioid mechanisms of action. The reduced incidence of some of the typical opioid-induced side effects, compared to equianalgesic doses of classical opioids, supports the hypothesis that tapentadol analgesia is only partially mediated by opioid agonist mechanisms. Both the pre-clinical and clinical profiles appear to be differentiated from those of classical opioids.
Development of a System for Diagnostic-While-Drilling (DWD) (2003)

Abstract This paper describes development of a prototype Diagnostic-While-Drilling (DWD) system that provides high-speed, realtime downhole data while drilling. The system has been demonstrated in both laboratory and field drilling. Project background, benefits, major technical challenges, and field test planning and results are described.
LANCET: local area network comprehensive evaluation tool (2003)

The features and capabilities of the local area network comprehensive evaluation tool (LANCET) are described. LANCET is a network monitoring and management package developed for a Unix workstation which incorporates many of the capabilities of special purpose network monitoring hardware. Traffic monitoring, generation, and display features of the system are discussed. Future extensions to the system are proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Protective effects of bradykinin on the ischaemic heart: implication of the B<sub>1</sub> receptor (1993)

1. We studied the role of bradykinin (BK) and its active metabolite Des-Arg9-BK on noradrenaline release in association with the incidence of ventricular arrhythmias at reperfusion of the ischaemic myocardium. 2. Experiments were performed in Langendorff perfused isolated hearts of rats subjected to 30 min no flow followed by 5 min reperfusion. The electrocardiogram was monitored continuously and noradrenaline was measured in the effluent as well as in the myocardial tissue. 3. In untreated hearts, cumulative noradrenaline overflow following global ischaemia reached 226 +/- 35 pmol g-1 of heart (n = 8, P < 0.05) during the 5 min of reperfusion along with ventricular tachycardia and/or fibrillation. A decrease in myocardial noradrenaline (-31%) was also observed. 4. Bradykinin perfused at concentrations between 0.01 and 1 microM, 10 min before flow was stopped and at reperfusion, inhibited noradrenaline overflow in a concentration-dependent manner. At a concentration of 1 microM, bradykinin completely abolished noradrenaline overflow. For the same concentration of bradykinin, myocardial noradrenaline contents were significantly higher (n = 5-8, P < 0.05). Ventricular fibrillation but not ventricular tachycardia was also prevented. 5. Des-Arg9-BK (0.1 microM) in the same experimental conditions had similar effects. While Hoe 140, a selective antagonist at B2 receptors, did not abolish the effects of bradykinin, Lys [Leu8] Des-Arg9-BK, an antagonist at B1 receptors, abolished the effects of both Des-Arg9-BK and bradykinin. 6. These results suggest that the cardioprotective action of bradykinin in the preparation may be mediated partially by an inhibitory effect on noradrenaline liberation which could be mediated by the activation of B1 receptors.
10-Gb/s, 100-km normal fiber transmission experiment employing a modified prechirp technique (1991)

The high-bit-rate and long span optical-fiber transmission system requires sufficient loss and dispersion margin for transmission. Recent multiple-gigabit transmission experiments have demonstrated that erbium-doped fiber amplifiers (EDFA's) can make the allowable loss margin larger in the 1.55- μm wavelength region. However, in this high-bit-rate region, the transmission systems suffer from dispersion limitations when 1.3- μm zero-dispersion normal fibers (SMF) are used. For example, in 10-Gb/s systems, even with an optimized LiNo3 external modulator, the transmission span has been limited to ~50 km by the fiber dispersion1 The same limitation applies to systems that use the dispersion compensation technique called prechirping technique.2 This paper proposes a modified prechirp technique, which makes large dispersion compensation possible by optically multiplexing the prechirped return-to-zero (RZ) signals. We have carried out a 10-Gb/s, 100-km SMF transmission experiment with this technique.