gebhart/patrepeval huggingface dataset:
Mutation analysis in 51 patients with haemophilia A: report of 10 novel mutations and correlations between genotype and clinical phenotype (2005)

We report the results of genetic analysis on a series of 51 patients attending this Haemophilia Comprehensive Care Centre. The most common cause of severe haemophilia A--the factor VIII intron 22 inversion was detected in eight families and the factor VIII intron 1 inversion in three families. Mutation analysis was carried out on the remaining patients by nucleotide sequencing of genomic DNA after screening with conformation-sensitive gel electrophoresis (CSGE) or denaturing high-performance liquid chromatography (dHPLC). A total of 27 different FVIII non-inversion mutations were detected. Severe haemophilia was associated with 12 null mutations (six nonsense, six frameshift) and four missense mutations. A further 11 different missense mutations were associated with moderate or mild disease. To our knowledge, six null mutations [1950del 4(tttg), 3270-75insA, 4416del 10, 6735-38delA, W1029X, Y1792X] and four missense mutations (E1682K, M1947V, P2048L, P2143L) have not been previously published. Each novel missense mutation occurred at a highly conserved residue, no other candidate mutation was detected on screening the entire coding region of the FVIII gene and they were not detected in a screen of individuals without haemophilia A. The genotype-phenotype correlations of the FVIII mutations detected will be discussed.
Corrosion Inhibition of Mild Steel in Acidic Solutions Using 1,2,4-Triazolo[1,5-a]pyrimidine (2018)

The inhibiting action, thermodynamics, and adsorptive properties of 1, 2, 4-triazolo[1, 5-a]pyrimidine (TP) have been investigated for the corrosion of mild steel in 0.5 M H2SO4 and 0.5 M H3PO4 solutions by means of potentiodynamic, electrochemical impedance spectroscopy techniques and quantum chemical calculations. Results obtained revealed that TP is more effective in 0.5 M H3PO4 than in 0.5 M H2SO4. Theoretical fitting of different adsorption isotherms such as Langmuir, Flory–Huggins, Temkin, and the kinetic-thermodynamic models were tested. The obtained experimental data fitted all the applied adsorption isotherms except Langmuir. The thermodynamic activation parameters were calculated. The potential of zero charge was also determined using AC measurements to clarify the nature of surface charge of the mild steel in both acidic solutions. Quantum chemical parameters were calculated and explained. The data explained that the inhibition of mild steel in both acidic solutions takes place through physicochemical adsorption mechanism.
Mystery of the Alkali Metals: Giant Moments of Fe and Co on and in Cs films (1999)

Thin films of Cs are covered with $\frac{1}{100}$ of a monolayer of Fe or Co. Then the impurities are covered with several atomic layers of Cs. The magnetization of the films is measured by means of the anomalous Hall effect. The magnetization follows a Brillouin function with a magnetic moment of about 8 Bohr magnetons for Co on the surface and in the bulk of the Cs. For the Fe impurities, a magnetic moment of 7 Bohr magnetons is observed. These large moments suggest that the $3d$ impurities polarize the conduction electrons of the Cs similar to the giant moments in Pd.
Large infarcts in the middle cerebral artery territory Etiology and outcome patterns (1998)

Large supratentorial infarctions play an important role in early mortality and severe disability from stroke. However, data concerning these types of infarction are scarce. Using data from the Lausanne Stroke Registry, we studied patients with a CT-proven infarction of the middle cerebral artery (MCA) territory that covered at least two of three MCA subterritories (deep, superficial anterior [superior] and posterior [inferior] territory). We compared these patients with patients presenting more limited infarction in the MCA territory. Our study group of large MCA (laMCA) infarction contained 208 patients, corresponding to 7.6% of all ischemic infarctions in the Lausanne Stroke Registry. Seventy-two patients had complete infarction in the whole MCA territory (coMCA). Internal carotid artery (ICA) occlusion (41%) and ICA dissection (12%) were more common than in limited superficial MCA (lsMCA) infarct and anterior circulation infarct (p < 0.001). Among the patients without ICA occlusion, atrial fibrillation (33%; p < 0.002) and cardiogenic embolism in general (54%; p < 0.001) were more frequent in laMCA than in lsMCA infarct. Severe neurologic deficit (hemiplegia and hemisensory loss in the face, arm and leg, hemianopia, global aphasia, reduced consciousness) was more common than in other types of infarct. A combination of these symptoms had a positive predictive value for laMCA infarction of 0.73 (sensitivity for left side laMCA infarcts, 0.56). Mortality (17%) and severe disability (50%) were higher with laMCA than for other infarcts (p < 0.001). Sixteen of the 35 deaths could be attributed to brain edema. Reduced consciousness, hemianopia, and coMCA infarction were independent predictors of death or severe disability; for death only, coma was an independent predictor. Patients who died because of brain edema were younger than patients whose death was due to other causes (mean age, 57 versus 73 years; p < 0.001); they also died sooner (mean time of death after stroke, 5 versus 37 days; p < 0.001). Furthermore, patients who developed coma on the day of admission were more likely to die because of brain death (p < 0.001). Large middle cerebral artery infarction is associated with cardiogenic embolism, ICA occlusion, and ICA dissection. It is a major predictor of death and severe disability, although a lower frequency of malignant brain infarction was found than previously reported.
Assays for Fibrinogen and Its Derivatives (1977)

(1977). Assays for Fibrinogen and Its Derivatives. CRC Critical Reviews in Clinical Laboratory Sciences: Vol. 8, No. 2, pp. 145-192.
Sequential Evaluation of QNDE Devices for Underground Storage Tanks (2003)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Y. H. Michlin; Sequential Evaluation of QNDE Devices for Underground Storage Tanks. AIP Conf. Proc. 27 March 2003; 657 (1): 907–914. https://doi.org/10.1063/1.1570231 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Origami by frontal photopolymerization (2017)

Origami structures are of great interest in microelectronics, soft actuators, mechanical metamaterials, and biomedical devices. Current methods of fabricating origami structures still have several limitations, such as complex material systems or tedious processing steps. We present a simple approach for creating three-dimensional (3D) origami structures by the frontal photopolymerization method, which can be easily implemented by using a commercial projector. The concept of our method is based on the volume shrinkage during photopolymerization. By adding photoabsorbers into the polymer resin, an attenuated light field is created and leads to a nonuniform curing along the thickness direction. The layer directly exposed to light cures faster than the next layer; this nonuniform curing degree leads to nonuniform curing-induced volume shrinkage. This further introduces a nonuniform stress field, which drives the film to bend toward the newly formed side. The degree of bending can be controlled by adjusting the gray scale and the irradiation time, an easy approach for creating origami structures. The behavior is examined both experimentally and theoretically. Two methods are also proposed to create different types of 3D origami structures.
Hepatitis C Virus Envelope DNA-based Immunization Elicits Humoral and Cellular Immune Responses (1998)

The vaccine development for hepatitis C virus (HCV) is highly urgent to prevent non A and non B hepatitis. It was recently shown that the HCV envelope proteins appeared to the key viral antigens to induce protective immunity. To generate immune responses to the HCV envelope proteins on the DNA-based immunization, various envelope gene-containing plasmids were constructed. For efficient expression and secretion of envelope proteins, the signal sequence of each envelope protein was replaced with either herpes simplex virus type-1 (HSV-1) gD or signal sequence of gD and truncated C-terminal hydrophobic regions of envelope proteins. The intramuscular injection of these plasmids generated a significant level of antibody titers to the E1 and E2 proteins, which maximally reached 850 and 25,000 respectively. The secreted form of each envelope protein and the fusion of the highly immunogenic gD proteins were shown to have no significant effect on generating immune responses to the envelope proteins. In addition, immunized rats appeared to generate antibodies directed to the homologous HVR-1 peptide. Splenic lymphocytes from immunized rats were shown to induce significant T-cell proliferative responses with the stimulation of recombinant E1 and E2 proteins. Our results demonstrated that the HCV envelope-DNA based immunization could elicit both humoral and cellular immune responses.
Interleukin-6 receptor signaling. II. Bio-availability of interleukin-6 in serum. (1999)

Interleukin-6 (IL-6) is used as a growth factor by various tumor cells. It binds to a gp80 specific receptor (IL-6R) and then to a gp130 transducing chain. Both receptor chains are released as soluble functional proteins which circulate in biological fluids. With a view to studying the physiological role of these soluble receptors, both proteins were purified from human plasma. Surface plasmon resonance was used to measure the kinetic constants of equilibria between IL-6 and natural sIL-6R, and between the IL-6/sIL-6R complex and soluble gp130. Kd values were found to be 0. 9 and 2.3 nM respectively. Soluble natural IL-6R and gp130 were also found to interact with a Kd of 2.8 nM in the absence of IL-6. By using these Kd values, a mathematical simulation predicted that 1) within a large range of IL-6, sIL-6R and sgp130 concentrations, free IL-6 represents 30% of the total circulating cytokine, 2) sIL-6R overconcentrations lead to dramatic changes of the concentration of free IL-6, 3) increased concentrations of sgp130 should produce an efficient buffering effect on the IL-6/sIL-6R complex without incidence on the level of free IL-6. According to this model, the IL-6/sIL-6R complex appears to be an important support of IL-6 signaling in the most commonly encountered in vivo situations. The concentration of this complex is directly under the control of the concentration of sIL-6R; its bio-availability should be efficiently buffered by increased sgp130 concentrations.
Red‐Shifted Fluorescent Aminated Derivatives of a Conformationally Locked GFP Chromophore (2014)

A novel class of fluorescent dyes based on conformationally locked GFP chromophore is reported. These dyes are characterized by red-shifted spectra, high fluorescence quantum yields and pH-independence in physiological pH range. The intra- and intermolecular mechanisms of radiationless deactivation of ABDI-BF2 fluorophore by selective structural locking of various conformational degrees of freedom were studied. A unique combination of solvatochromic and lipophilic properties together with "infinite" photostability (due to a dynamic exchange between free and bound dye) makes some of the novel dyes promising bioinspired tools for labeling cellular membranes, lipid drops and other organelles.
Stacking and polarization control of wavelength-tunable (1.55μm region) InAs∕InGaAsP∕InP (100) quantum dots (2006)

Stacking and polarization control of wavelength-tunable InAs quantum dots (QDs) embedded in lattice-matched InGaAsP on InP (100) grown by metalorganic vapor-phase epitaxy is demonstrated. Wavelength control over the 1.55μm region at room temperature is achieved by inserting ultrathin GaAs interlayers underneath the QDs and adjusting the amount of InAs. For widely stacked QDs with a 40nm separation layer, the linear dependence of the emission wavelength on the GaAs interlayer thickness coincides with that of single QD layers revealing the reproduction of identical QD layers. For closely stacked QDs with 4nm separation layer, the emission wavelength as a function of the GaAs interlayer thickness is systematically redshifted and the linewidth is reduced indicating vertical electronic coupling which is proven by the linear polarization of the cleaved-side luminescence changing from in-plane to isotropic.
Multiphoton discrimination at telecom wavelength with charge integration photon detector (2005)

We present a charge integration photon detector (CIPD) that enables the efficient measurement of photon number states at the telecom-fiber wavelengths with a quantum efficiency of 80% and a resolution less than 0.5 electrons at 1Hz sampling. The CIPD consists of an InGaAs pin photodiode and a GaAs JFET in a charge integration amplifier, which is cooled to 4.2K to reduce thermal noise and leakage current. The charge integration amplifier exhibits a low noise level of 470nV∕Hz1∕2. The dark count is as low as 500electrons∕h.
Software Life-Extension: A New Countermeasure to Software Aging (2012)

This paper presents software life-extension, a new technique for counteracting software aging by preventive operation to extend the lifetime of software execution. Software aging is a phenomenon of progressive degradation of execution environment due to aging-related software faults and it might cause resource depletion resulting in system failures. To extend the lifetime of the software affected by aging, we use a virtual machine to execute the software and allocate additional memory to the virtual machine upon software aging detection. Although software life-extension is a temporal solution as it only postpones the occurrence of a failure, it provides a simple, cost-effective, and non-intrusive countermeasure to software aging. The feasibility and effectiveness of software life-extension are studied by the experiments on memcached, a widely adopted general-purpose in-memory cache server. From the experimental results, we present a Semi-Markov process (SMP) describing the general behavior of software life-extension and analyze the model which gives the prediction of the system availability as well as the user-perceived availability.
HINTA: A Linearization Algorithm for Physical Clustering of Complex OLAP Hierarchies. (2001)

Hierarchies are an important means to categorize data stored in OLAP systems. OLAP queries follow the drill/slice/dice-paradigm and therefore exhibit navigation patterns that follow the hierarchy of a dimension. In real-world applications, hierarchies are often unbalanced and share levels, resulting in complex hierarchy structures. So far, encoding methods for simple structured hierarchies have been introduced to handle hierarchies efficiently for query processing. In this paper we propose the HINTA algorithm to compute the clustering order for complex hierarchies by linearization. The physical clustering of OLAP data computed by HINTA significantly improves the performance of OLAP queries. HINTA enables clustering of complex hierarchies that can share hierarchy levels in several classifications over one dimension.
Low-voltage inkjetted organic transistors for printed RFID and display applications (2006)

We demonstrate printed organic transistors with sub-10V V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD </sub> . Using inkjetted nanoparticle conductors, a polymer dielectric, and a pentacene precursor semiconductor, we demonstrate devices on plastic with mobilities >0.05cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /V-s and on-off ratios >10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> . Thus, for the first time, we demonstrate devices with operating specifications approaching those required for low-cost electronic systems
Structure-activity relationships of carbapenems that determine their dependence on porin protein D2 for activity against Pseudomonas aeruginosa (1995)

A number of carbapenem derivatives were examined to determine the structure-activity relationships required for dependence on porin protein D2 for activity against Pseudomonas aeruginosa. As suggested by J. Trias and H. Nikaido (Antimicrob. Agents Chemother. 34:52-57, 1990), carbapenem derivatives, such as imipenem and meropenem, containing a sole basic group at position 2 of the molecule utilize the D2 channel for permeation through the outer membrane of pseudomonads; they are more active against D2-sufficient strains of P. aeruginosa. Our results indicated that carbapenems with a basic group at position 1 or 6 of the molecule did not depend on the D2 channel for activity; i.e. they were equally active against D2-sufficient and D2-deficient pseudomonal strains. However, addition of a basic group at position 1 or 6 of a carbapenem derivative already containing a basic group at position 2 resulted in its lack of dependency on the D2 pathway. Comparison between meropenem and its 1-guanidinoethyl derivative, BMY 45047, indicated that they differed in their dependence on D2; while meropenem required the D2 channel for uptake, BMY 45047 activity was independent of D2. Meropenem and BMY 45047 had similar affinities for the penicillin-binding proteins of P. aeruginosa. However, BMY 45047 and meropenem differed in the morphological changes that they induced in pseudomonal cells. While meropenem induced filamentation, BMY 45047 induced filaments only in BMS-181139-resistant mutants and not in imipenem-resistant mutants or in carbapenem-susceptible P. aeruginosa strains. These results suggested that in Mueller-Hinton medium the uptake of BMY 45047 through the non-D2 pathway is more rapid than that of meropenem through the D2 porin. In summary, the presence of a basic group at position 2 of a carbapenem is important for its preferential uptake by the D2 channel. However the addition of a basic group at position 1 or 6 of a carbapenem already containing a basic group at position 2 dissociates its necessity for porin protein D2 for activity.
Synthesis and Luminescence Properties of Colloidal YVO<sub>4</sub>:Eu Phosphors (2000)

Concentrated colloidal solutions of well-dispersed YVO4:Eu nanoparticles are synthesized by precipitation reactions at room temperature and stabilized by sodium hexametaphosphate. X-ray diffraction and electron microscopy characterizations show that the crystalline nanoparticles exhibit an ellipsoidal form with two characteristic dimensions of around 15 and 30 nm. In comparison with the bulk, a lower luminescence efficiency as well as a higher concentration quenching are observed. These deviations are explained as the variations of some characteristics of the colloidal samples, such as the crystallinity and the surface chemistry. When these parameters are optimized, the quantum yield of the luminescence reaches 38% for the nanoparticles containing a europium concentration of 15%.
Laser Tattoo Removal: A Review (2011)

QS lasers can effectively and safely remove different types of unwanted tattoos.
Diffuse Large B-Cell Lymphoma (2021)

DLBCL, an aggressive cancer, accounts for about 30% of all lymphomas. Empirical combination chemotherapy cures about 65% of patients initially, with another 20 to 25% cured with salvage therapy. Efforts are ongoing to tailor therapy to particular genetic lesions.
Three-dimensional printed millifluidic devices for zebrafish embryo tests (2015)

Implementations of Lab-on-a-Chip technologies for in-situ analysis of small model organisms and embryos (both invertebrate and vertebrate) are attracting an increasing interest. A significant hurdle to widespread applications of microfluidic and millifluidic devices for in-situ analysis of small model organisms is the access to expensive clean room facilities and complex microfabrication technologies. Furthermore, these resources require significant investments and engineering know-how. For example, poly(dimethylsiloxane) soft lithography is still largely unattainable to the gross majority of biomedical laboratories willing to pursue development of chip-based platforms. They often turn instead to readily available but inferior classical solutions. We refer to this phenomenon as workshop-to-bench gap of bioengineering science. To tackle the above issues, we examined the capabilities of commercially available Multi-Jet Modelling (MJM) and Stereolithography (SLA) systems for low volume fabrication of optical-grade millifluidic devices designed for culture and biotests performed on millimetre-sized specimens such as zebrafish embryos. The selected 3D printing technologies spanned a range from affordable personal desktop systems to high-end professional printers. The main motivation of our work was to pave the way for off-the-shelf and user-friendly 3D printing methods in order to rapidly and inexpensively build optical-grade millifluidic devices for customized studies on small model organisms. Compared with other rapid prototyping technologies such as soft lithography and infrared laser micromachining in poly(methyl methacrylate), we demonstrate that selected SLA technologies can achieve user-friendly and rapid production of prototypes, superior feature reproduction quality, and comparable levels of optical transparency. A caution need to be, however, exercised as majority of tested SLA and MJM resins were found toxic and caused significant developmental abnormalities in zebrafish embryos. Taken together, our data demonstrate that SLA technologies can be used for rapid and accurate production of devices for biomedical research. However, polymer biotoxicity needs to be carefully evaluated.
Pancreatic Hormone Receptors on Islet Cells* (1985)

To assess whether islet cells are equipped with recognition units which allow an intra-islet regulation via released hormones, the presence of insulin and glucagon receptors is investigated on purified pancreatic A and B cells. Mono-[125I]glucagon is shown to bind specifically to islet B cells, with similar binding characteristics as in isolated hepatocytes but involving less receptors per cell (2.10(4) per B cell vs. 8.10(5) per liver cell). Binding is half-maximally displaced by 5.10(-9) M glucagon, a concentration known to induce half-maximal biological effects in isolated B cells. These results are compatible with a regulatory role of glucagon in the insulin release process. No specific binding of [125I]tyr-A14-insulin is detected on pancreatic A cells. In order to increase receptor assay sensitivity, [123I]tyr-A14-insulin is prepared with at least 5-fold higher specific activity. Its validity for in vitro receptor analysis is demonstrated in IM-9 lymphocytes, where insulin binding is detectable down to 10(4) cells/ml. However, no insulin-binding sites are identified on pancreatic A cells, even at 10(6) cells/ml. If isolated A cells contain high affinity insulin receptors, their number should be inferior to 400 per cell, which is 50- to 500-fold lower than in classical insulin target cells. These findings explain the insensitivity of the glucagon release process to acute exposure to insulin.