gebhart/patrepeval huggingface dataset:
Guided wave helical ultrasonic tomography of pipes (2003)

Ultrasonic guided waves have been used for a wide variety of ultrasonic inspection techniques. We describe here a new variation called helical ultrasound tomography (HUT) that uses guided ultrasonic waves along with tomographic reconstruction algorithms that have been developed by seismologists for what they call "cross borehole" tomography. In HUT, the Lamb-like guided waves travel the various helical criss-cross paths between two parallel circumferential transducer arrays instead of the planar criss-cross seismic paths between two boreholes. Although the measurement itself is fairly complicated, the output of the tomographic reconstruction is a readily interpretable map of a quantity of interest such as pipe wall thickness. In this paper we demonstrate HUT via laboratory scans on steel pipe segments into which controlled thinnings have been introduced.
Address-Value Delta (AVD) Prediction: Increasing the Effectiveness of Runahead Execution by Exploiting Regular Memory Allocation Patterns (2006)

While runahead execution is effective at parallelizing independent long-latency cache misses, it is unable to parallelize dependent long-latency cache misses. To overcome this limitation, this paper proposes a novel technique, address-value delta (AVD) prediction. An AVD predictor keeps track of the address (pointer) load instructions for which the arithmetic difference (i.e., delta) between the effective address and the data value is stable. If such a load instruction incurs a long-latency cache miss during runahead execution, its data value is predicted by subtracting the stable delta from its effective address. This prediction enables the pre-execution of dependent instructions, including load instructions that incur long-latency cache misses. We describe how, why, and for what kind of loads AVD prediction works and evaluate the design tradeoffs in an implementable AVD predictor. Our analysis shows that stable AVDs exist because of patterns in the way data structures are allocated in memory. Our results show that augmenting a runahead processor with a simple, 16-entry AVD predictor improves the average execution time of a set of pointer-intensive applications by 12.1%.
Synthesis and Properties of a Novel Water-Soluble Lactose-Containing Polymer and Its Cross-Linked Hydrogel (1997)

A simple and efficient method for the synthesis of lactose-based homopolymers from lactose O-(p-vinylbenzyl)oxime (4) is described. Free radical polymerization of the new oxime monomers proceeded smoothly in an aqueous solution using potassium persulfate (KPS) and N,N,N‘,N‘-tetramethylethylenediamine (TMEDA) as the initiating system and gave water-soluble homopolymers in good yields. These synthetic lactose-based polymers had high molecular weights and narrow polydispersities (Mw/Mn: 1.20−1.35) as determined by size exclusion chromatography, in conjunction with multiangle laser light scattering (SEC−MALLS). The Mark−Houwink equation was obtained as [η] = 2.15 × 10-4Mv0.73. When the monomer was copolymerized with the cross-linking reagent N,N‘-methylenebis(acrylamide) (BisA) (16% mol), hydrogels were formed which swelled as much as 21-fold in deionized water. These gels have potential applications as biocompatible materials.
[Critical observations on the use of phenolphthalein monophosphate as a substrate for the determination of prostatic acid phosphatase (author's transl)]. (1977)

At pH 10, which is in the alkaline measurement range, phenolphthalein is bound by albumin. The resonance system of this acid-base indicator cannot therefore be completely formed, and the colour intensity is correspondingly lower. Albumin also binds phenolphthalein monophosphate at pH 4-8, in the pH range of the enzymic reaction. Depending on the relative concentrations, the substrate concentration is therefore either suboptimal (manifested as a lower catalytic concentration of phosphatase), or the substrate excess is bound by albumin, so that the substrate inhibition of the phosphatase is decreased or abolished. Binding of phenolphthalein and its monophosphate to albumin is partly prevented by the addition of alcohol. These results show that the determination of prostate phosphatase with the substrate phenolphthalein monophosphate is markedly influenced by various factors. The interpretation of the observed colour intensity is therefore difficult, and the calculation of the catalytic concentration is frequently subject to error.
Humoral Immune Response and Assessment of Vaccine Virus Shedding in Calves Receiving Modified Live Virus Vaccines Containing Bovine Herpesvirus‐1 and Bovine Viral Diarrhoea Virus 1a (2003)

Susceptible calves were administered modified live virus (MLV) vaccines containing bovine herpesvirus-1 (BHV1) and bovine viral diarrhoea type 1 (BVDV1a) strains intramuscularly, with one vaccine containing both MLV and inactivated BHV-1 and inactivated BVDV1a. There was no evidence of transmission of vaccine (BHV-1 and BVDV1a) strains to susceptible non-vaccinated controls commingled with vaccinates. No vaccinates had detectable BHV-1 in peripheral blood leucocytes (PBL) after vaccination. Each of three vaccines containing an MLV BVDV1a strain caused a transient BVDV vaccine induced viremia in PBL after vaccination, which was cleared as the calves developed serum BVDV1 antibodies. The vaccine containing both MLV and inactivated BHV-1 induced serum BHV-1 antibodies more rapid than MLV BHV-1 vaccine. Two doses of MLV BHV-1 (days 0 and 28) in some cases induced serum BHV-1 antibodies to higher levels and greater duration than one dose.
Analysis, design, and evaluation of three-phase three-wire isolated ac-dc converter implemented with three single-phase converter modules (2016)

In this paper, a control method for three single-phase isolated ac-dc converter modules employed to implement an isolated three-phase, three-wire ac-dc converter is presented and its detailed design procedure provided. In the described control the input voltages of the Y-connected single-phase modules with floating common Y point are kept within a safe range by equalizing their input admittances. It is shown that for obtaining equal input admittances of the three PFC front stages, the outputs of the PFC voltage controllers should be equal. This is achieved by adjusting the reference currents of the current controllers in the output dc-dc stages. The performance of the presented control with both balanced and unbalanced source voltages, as well as with a phase fault (open or short circuit) is evaluated by Matlab/Simulink simulations and verified experimentally on a 6-kW prototype.
La pharmacogénétique : application aux anticoagulants oraux (2003)

Au cours des traitements anticoagulants oraux par les antivitamines K (AVK), de grandes variations dans la reponse sont observees. Il s‘agit soit de reactions exagerees avec un risque hemorragique majeur (les accidents hemorragiques lies au AVK constituent la premiere cause d‘hospitalisations liees a des accidents iatrogenes), soit de resistances necessitant des posologies elevees. Des facteurs genetiques lies au metabolisme expliquent en partie ces differences interindividuelles dans la reponse. Le metabolisme des AVK est principalement hepatique et le cytochrome P450 2C9 (CYP2C9) est l‘enzyme majoritairement responsable de leur elimination, en particulier pour les derives coumariniques (warfarine ou Coumadine ®, acenocoumarol ou Sintrom ®). L‘activite du CYP2C9 peut varier sous l‘influence de facteurs environnementaux (alimentation, medicaments), physiopathologiques ou genetiques (polymorphismes genetiques). Dans les populations caucasiennes, il existe deux principaux alleles variants (CYP2C9*2 et CYP2C9*3) qui sont a l‘origine d‘une baisse de l‘activite enzymatique. De nombreuses etudes cliniques ont maintenant etabli que les sujets porteurs de ces alleles variants necessitaient des doses moyennes plus faibles de warfarine ou d‘acenocoumarol, plus particulierement chez les porteurs de l‘allele CYP2C9*3. De plus, la presence de l‘allele CYP2C9*3 a ete associee a une augmentation du risque hemorragique. Les bases moleculaires de la resistance aux AVK restent a etablir, mais une augmentation du metabolisme liee a une activite elevee du CYP2C9 ou des variations de la cible pharmacologique des AVK sont possibles. Le genotypage des sujets pour le CYP2C9 avant l‘initiation d‘un traitement par AVK devrait permettre une amelioration de la prise en charge therapeutique et une meilleure prediction du risque hemorragique.
Photo-Reactive and Non-Natural Amino Acid Epitopes of Human WT1 Enhance Immunogenicity and Allow Kinetic Study of Antigen Processing. (2007)

Abstract Wilms tumor protein (WT1) is a transcription factor selectively over expressed in several types of leukemia and solid tumors, making it a promising potential target antigen for immunotherapy. Several open clinical trials use native or altered peptide sequences derived from the WT1 protein in order to overcome the weak immunogenicity of the self-antigen. Here we report a new strategy to circumvent tolerance by designing peptides that incorporate non-natural amino acids into the native sequence of WT1 peptides. Starting from the nonamer sequences WT1 187–195 and WT1 235–243, eight peptides containing natural amino acids and nine peptides in which different chemical modifications (fluorination, photo-reactive azido groups or benzophenone groups) were introduced at major histocompatibility complex (MHC) and T cell receptor binding positions, were synthesized. The new non-natural peptides could stabilize MHC class I molecules better than the native sequences and were also able to elicit strong specific T-cell responses. Photo-reactive peptides were additionally modified with biotin handles to allow streptavidin-biotin pull down and western blot analysis of kinetics of binding and catabolism. Upon UV irradiation, these peptides covalently bound to MHC molecules on the live cells; clearance of the peptide-MHC covalent complex occurred over 24 hours, consistent with the T2 thermo-stabilization data for the same peptide. Further catabolic studies may elucidate the important or novel cellular proteins involved in antigenic peptide processing and cross presentation and should aid in vaccine development. We are investigating whether covalent interaction with the MHC may lead to alterations in immune responses as well. T cells stimulated with one of the synthetic peptides (WT1J-W4WF) cross-reacted with the native WT1J sequence and were able to kill WT1 positive HLA-A0201 matched acute lymphoblastic leukemia cell lines. In conclusion, this study shows that peptides with non-natural amino acids can be successfully incorporated into T cell epitopes to provide increased immunogenicity and novel biological information.
Treatment of hepatitis Delta (2013)

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Expression of cytokine-like genes JE and KC is increased during renal ischemia (1991)

Both mitogenic and inflammatory phenomena accompany the renal response to ischemic injury. Previous studies have shown that several nuclear-binding members of the immediate early genes are prominently expressed after renal ischemia and may underlie the mitogenic response to such injury. We now report on the expression of JE and KC, other growth-factor-responsive genes that code for small secreted glycoproteins with cytokine-like properties, which may play a role in inflammation. The expression of the immediate early genes JE and KC was determined in rat kidney tissue at varying time points after release of a 50-min period of bilateral renal hilar clamping. Relative levels of mRNA for JE and KC were analyzed by Northern blot analysis of cortical and outer stripe mRNA. KC mRNA rose rapidly to peak values at 1 h and returned toward low baseline levels by 24 h after release of the hilar clamp. By contrast, JE mRNA reached peak levels later and remained elevated for at least 96 h after ischemia. JE antigen was localized immunocytochemically to the apical regions of the cortical and medullary thick ascending limbs as well as in the lumen of the distal nephron in ischemic kidneys. Cells of the glomerulus and proximal tubules were negative for JE antigen. In contrast to the increase in JE and KC mRNA, steady-state levels of uromodulin (Tamm Horsfall) mRNA, a cytokine binding protein also made by the thick ascending limb, declined to virtually undetectable levels by 24 h after ischemia. Thus the increases in JE and KC are not generalized phenomena.(ABSTRACT TRUNCATED AT 250 WORDS)
Dissection of Drought Responses in Arabidopsis (2010)

Dissection of Drought Responses in Arabidopsis، للحصول على النص الكامل يرجى زيارة مكتبة الحسين بن طلال في جامعة اليرموك او زيارة موقعها الالكتروني
Remarkable In Vivo Nonlinear Photoacoustic Imaging Based on Near-Infrared Organic Dyes (2016)

Two near-infrared dyes featuring good dispersion and light-harvesting property present a remarkable nonlinear photoacoustic response in vitro and in vivo comparing with conventional gold nanorods. This study benefits the fabrication of drug delivery platforms with accurate targeting and control effect under photoacoustic image guidance.
Interactive modelling of 3D-environments (2003)

Direct 3D-measurement of an environment is increasingly required for many applications such as reverse engineering and CAD modelling. 3D CAD Models are more and more important as reconstruction and documentation of existing plants as well as design studies of new plants are done in 3D recently. Especially simulation and optimisation of plants and manufacturing lines is becoming more and more important. Besides these aspects generation of basic models for mobile robot navigation (initial map) is important, as this map is the base for human robot interaction in real environments (industry, households). This calls for the development of a physical system to survey the environment as well as software tools for transforming measurement data into CAD models. Z+F have developed a laser scanner performing fast and exact, non-contact measurements. The 3D point cloud, resulting from the measurements, has to be transformed into a CAD model for documentation purposes. Conversion from point data to CAD objects is achieved by the interactive application of powerful algorithms which facilitate rapid point-to-primitive translation.
Efficacy of triplet regimen antiemetic therapy for chemotherapy‐induced nausea and vomiting (CINV) in bone and soft tissue sarcoma patients receiving highly emetogenic chemotherapy, and an efficacy comparison of single‐shot palonosetron and consecutive‐day granisetron for CINV in a randomized, single‐blinded crossover study (2014)

The first aim of this study was to evaluate combination antiemetic therapy consisting of 5-HT3 receptor antagonists, neurokinin-1 receptor antagonists (NK-1RAs), and dexamethasone for multiple high emetogenic risk (HER) anticancer agents in bone and soft tissue sarcoma. The second aim was to compare the effectiveness of single-shot palonosetron and consecutive-day granisetron in a randomized, single-blinded crossover study. A single randomization method was used to assign eligible patients to the palonosetron or granisetron arm. Patients in the palonosetron arm received a palonosetron regimen during the first and third chemotherapy courses and a granisetron regimen during the second and fourth courses. All patients received NK-1RA and dexamethasone. Patients receiving the palonosetron regimen were administered 0.75 mg palonosetron on day 1, and patients receiving the granisetron regimen were administered 3 mg granisetron twice daily on days 1 through 5. All 24 patients in this study received at least 4 chemotherapy courses. A total of 96 courses of antiemetic therapy were evaluated. Overall, the complete response CR rate (no emetic episodes and no rescue medication use) was 34%, while the total control rate (a CR plus no nausea) was 7%. No significant differences were observed between single-shot palonosetron and consecutive-day granisetron. Antiemetic therapy with a 3-drug combination was not sufficient to control chemotherapy-induced nausea and vomiting (CINV) during chemotherapy with multiple HER agents for bone and soft tissue sarcoma. This study also demonstrated that consecutive-day granisetron was not inferior to single-shot palonosetron for treating CINV.
A Comprehensive Review of Radiosurgery for Cerebral Arteriovenous Malformations: Outcomes, Predictive Factors, and Grading Scales (2008)

The management of cerebral arteriovenous malformations (AVMs) continues to present a challenge to neurosurgeons. The natural history of this condition, as well as the morbidity and mortality of therapeutic interventions, remains incompletely elucidated. Predictive factors and grading scales in AVM management allow risk-benefit analysis of treatment options and comparison of outcomes. Stereotactic radiosurgery is one of the established treatment modalities for AVMs and is generally used to treat lesions that are high risk for surgical resection. Radiosurgery aims to obliterate AVMs and thus prevent hemorrhage or seizure without any new or worsening of existing symptoms. Lesion characteristics and postsurgical complications differ markedly in patientstreated by radiosurgery versus microsurgery. Radiosurgery-based grading systems account for factors that have been associated with various aspects of radiosurgical outcomes including obliteration, hemorrhage, and postoperative complications, particularly those induced by radiation. The purpose of this paper is to describe the most current predictive factors and grading systems for radiosurgical treatment of cerebral AVMs.
Jitter effect on digital downconversion receiver with undersampling scheme (2004)

Undersampling phase modulated signals directly at high frequency band, the effect by ADC's aperture jitter characteristics and sampling clock instability of the system can not be ignored. The sampling jitter brings additional phase noise to the constellation pattern, thus the BER (bit error rate) performance will be degraded. This paper presents the relationship between the input frequency to ADC (analog-to-digital converter) and the sampling jitter in the digital IF (intermediate frequency) downconversion receiver with undersampling scheme. The computer simulation results with theoretical IF sampling receiver model and the measurement result with a real hardware will be presented. According to the results, for wireless LAN standard the effective IF QPSK signal input frequency of ADC was limited below around 300 MHz with RMS (root mean square) jitter of 25 ps for 40 MHz sampling rate.
Quantum money from knots (2012)

Quantum money is a cryptographic protocol in which a mint can produce a quantum state, no one else can copy the state, and anyone (with a quantum computer) can verify that the state came from the mint. We present a concrete quantum money scheme based on superpositions of diagrams that encode oriented links with the same Alexander polynomial. We expect our scheme to be secure against computationally bounded adversaries.
Increasing the length of tubular objects that can be measured using acoustic pulse reflectometry (1998)

Acoustic pulse reflectometry is a non-invasive technique for measuring the internal dimensions of tubular objects. A sound pulse is produced using a loudspeaker and injected into the object under investigation via a source tube. The resultant object reflections are recorded by a microphone embedded in the wall of the source tube. Analysis of the reflections yields information about the bore profile of the object. At present, there is a restriction on the length of object that can be measured using the standard reflectometer. This restriction arises because after the object reflections pass the microphone they undergo further reflection at the loudspeaker. These source reflections return to the microphone as unwanted signal. Hence, there is only a finite time over which the object reflections can be accurately recorded which, in turn, limits the length of object that can be measured. In this paper, a method for removing the length restriction is described. The method involves the cancellation of the incoming object reflections at the loudspeaker, thus preventing the formation of source reflections. The results achieved indicate the potential of the method for accurate measurement of longer objects.
Specific Features of Intramolecular Proton Transfer Reaction in Schiff Bases (2003)

The differences between the intramolecular proton transfer in Mannich and Schiff bases are discussed. The tautomeric forms being in equilibrium in both types of molecules are seriously different. In Mannich bases there are in equilibrium the forms of phenols and phenolates. In Schiff bases each of tautomers is strongly influenced by resonance between zwitterionic and keto structures. Despite the common opinion that the proton transfer forms in compounds with internal π-electronic coupling are mainly keto forms it is shown in this work, that in Schiff bases the content of keto structure is slightly less than zwitterionic one. Almost equal participation of both forms leads to effective resonance between them and stabilization of intramolecular hydrogen bond in this way.
Regularized reconstruction of 3D high-resolution magnetic resonance images from acquisitions of anisotropically degraded resolutions (2002)

We present an original method to reconstruct 3D magnetic resonance images of high resolution in the 3 directions of space from two anisotropic volumes. The resolution of each volume is degraded in a different direction. The reconstruction method is based on an optimization technique, the constraints being fidelity to the acquired data on the one hand, smoothness and edge preservation on the other hand. The interest of such a method is to significantly decrease the acquisition time of MR images, without degrading the spatial resolution.
Navigational support for robotic wheelchair platforms: an approach that combines vision and range sensors (2002)

An approach towards providing advanced navigational support to robotic wheelchair platforms is presented. In order to avoid any modifications to the environment, we propose an approach that employs computer vision techniques which facilitate space perception and navigation. Computer vision has not been introduced to date in rehabilitation robotics, since the former is not mature enough to meet the needs of this sensitive application. However, in the proposed approach, stable techniques are exploited that facilitate reliable, automatic navigation to any point in the visible environment. Preliminary results obtained from its implementation on a laboratory robotic platform indicate its usefulness and flexibility.
Direct saturation MRI: Theory and application to imaging brain iron (2009)

When applying RF saturation to tissue, MRI signal reductions occur due to magnetization transfer (MT) and direct saturation (DS) effects on water protons. It is shown that the direct effects, often considered a nuisance, can be used to distinguish gray matter (GM) regions with different iron content. DS effects were selected by reducing the magnitude and duration of RF irradiation to minimize confounding MT effects. Contrary to MT saturation spectra, direct water saturation spectra are characterized by a symmetric Lorentzian-shaped frequency dependence that can be described by an exact analytical solution of the Bloch equations. The effect of increased transverse relaxation, e.g., due to the presence of iron, will broaden this saturation spectrum. As a first application, DS ratio (DSR) images were acquired to visualize GM structures in the human brain. Similar to T(2)*-weighted images, the quality of DSR images was affected by local field inhomogeneity, but this could be easily corrected for by centering the saturation spectrum on a voxel-by-voxel basis. The results show that, contrary to commonly used T(2)*-weighted and absolute R(2) images, the DSR images visualize all GM structures, including cortex. A direct correlation between DSR and iron content was confirmed for these structures.