gebhart/patrepeval huggingface dataset:
Augmentation of the narrow traumatized anterior alveolar ridge to facilitate dental implant placement (2003)

Traumatic tooth loss leads to alveolar resorption especially in sagittal direction. This can be due to avulsion of bone substance during the accident itself or due to resorption of the alveolar crest that takes place afterwards. Shortage of bone can prevent proper positioning of dental implants unless the volume of bone is increased before implantation. In the maxillary anterior area, this is also an esthetic problem. Several treatment modalities have been presented to augment the bone. This report reviews the latest literature on bone grafting, bone substitutes, guided bone regeneration, osteocompression and distraction which are potentially useful in the anterior maxilla. A special emphasis is paid to the versatility of using a crestal split osteotomy, by means of chisels and osteotomes to widen the narrow ridge. Three examples are illustrated showing onlay grafting, preservation of alveolar width with alloplastic coral material and lateral widening of a narrow maxillary alveolar ridge, using the crestal splitting technique.
Inhibition of myogenesis by Notch: Evidence for multiple pathways (2008)

Notch signaling is critical for skeletal muscle development and regeneration, permitting the expansion of progenitor cells by preventing premature differentiation. We have interrogated the pathways through which ligand-mediated signaling inhibits myogenesis by identifying Notch target genes and assessing their impact on differentiation in vitro. Notch activation led to the robust induction of the transcriptional repressors Hey1 and HeyL in myoblasts, but only constitutive expression of Hey1 blocked myogenesis. siRNA-mediated knockdown of Hey1 had no effect on Notch's ability to inhibit differentiation, suggesting the existence of additional, possibly redundant pathways. We identified 82 genes whose expression was activated when C2C12 myoblasts were cultured in the presence of the Notch ligand Dll4. One of these, MyoR, is a novel Notch-responsive gene, whose protein product is known to repress myogenesis in vitro. siRNA-mediated knockdown of MyoR alone, or in combination with Hey1, was also ineffective at rescuing differentiation in the presence of Dll4. Our data support a model in which Notch signaling inhibits myogenesis through multiple pathways, two of which are defined by the Notch target genes Hey1 and MyoR.
Oxidative interactions between the erythrocyte membrane and phosphatidylcholine vesicles. (1994)

Sonicated unilamellar phosphatidylcholine vesicles induce hemoglobin oxidation in erythrocytes and resealed membrane fragments (buds) at pH 5.5. No such oxidation was observed in vesicle-bud mixtures at pH 7.4, in cells or buds suspended in pH 5.5 buffer, or in cells incubated with multilamellar lipid vesicles at pH 5.5. In buds, vesicle-induced hemoglobin oxidation was accompanied by lipid peroxidation and formation of covalent high molecular weight protein aggregates. The causative relationships among the oxidative events were examined using selective antioxidants and membrane fragments in which the cytoplasmic domain of band 3 was cleaved. Protein cross-linking and lipid peroxidation were found to be independent events, but both were found only in concert with heme oxidation. Further, vesicle-induced hemoglobin oxidation was found to be correlated with quasi-stable adsorption of intact vesicles to cells; intercalation of foreign lipid into the cell bilayer was not required. The inability of multilamellar vesicles to induce these low pH oxidative effects suggests a steric limitation on this cell-vesicle association. The results suggest that membrane component reorganization and patching induced by low pH may enhance vesicle adsorption, which in turn initiates oxidative damage.
Spin injection from Fe into Si(001):<i>Ab initio</i>calculations and role of the Si complex band structure (2008)

We study the possibility of spin injection from Fe into Si(001), using the Schottky barrier at the Fe/Si contact as tunneling barrier. Our calculations are based on density-functional theory for the description of the electronic structure and on a Landauer-B\"uttiker approach for the current. The current-carrying states correspond to the six conduction-band minima (pockets) of Si, which, when projected on the (001) surface Brillouin zone (SBZ), form five conductance hot spots: one at the SBZ center and four symmetric satellites. The satellites yield a current polarization of about 50%, while the SBZ center can, under very low gate voltage, yield up to almost 100%, showing a zero-gate anomaly. This extremely high polarization is traced back to the symmetry mismatch of the minority-spin Fe wave functions to the conduction-band wave functions of Si at the SBZ center. The tunneling current is determined by the complex band structure of Si in the [001] direction, which shows qualitative differences compared to that of direct-gap semiconductors. Depending on the Fermi level position and Schottky barrier thickness, the complex band structure can cause the contribution of the satellites to be orders of magnitude higher or lower than the central contribution. Thus, by appropriate tuning of the interface properties, there is a possibility to cut off the satellite contribution and to reach high injection efficiency. Also, we find that a moderate strain of 0.5% along the [001] direction is sufficient to lift the degeneracy of the pockets so that only states at the zone center can carry current.
IgE-Positive Duodenal Mast Cells in Patients with Food-Related Diarrhea (1991)

Thirty-seven consecutive adult patients with a history of adverse reactions to foods, manifested mainly as diarrhea, were investigated with skin prick test (SPT), IgE levels in serum, and the presence of IgE bound to mast cells in duodenal biopsy specimens. Nineteen percent had increased serum IgE levels indicating the presence of atopic disease and in 35% positive SPTs for one or several allergens related to their gastrointestinal symptoms were found. In 92% of the patients with positive SPTs to food, IgE-positive mast cells in duodenal biopsy specimens were found, twice as many as in patients with negative SPTs (47%). Forty-two percent of normal individuals without any adverse reactions to foods had IgE-bearing mast cells in their intestinal mucosa. The results showed that 'arming' of mast cells with IgE locally was relatively prominent but not consistent in the gut of patients with food-related diarrhea suggested to be allergic by positive SPT. Intestinal IgE-mediated hypersensitivity reactions could be of pathogenetic significance in most of these patients. However, since also half of the normal individuals were found to have IgE-positive intestinal mast cells, this phenomenon presumably also reflects a normal physiological defence mechanism.
A posteriori multi-probe locality sensitive hashing (2008)

Efficient high-dimensional similarity search structures are essential for building scalable content-based search systems on feature-rich multimedia data. In the last decade, Locality Sensitive Hashing (LSH) has been proposed as indexing technique for approximate similarity search. Among the most recent variations of LSH, multi-probe LSH techniques have been proved to overcome the overlinear space cost drawback of common LSH. Multi-probe LSH is built on the well-known LSH technique, but it intelligently probes multiple buckets that are likely to contain query results in a hash table. Our method is inspired by previous work on probabilistic similarity search structures and improves upon recent theoretical work on multi-probe and query adaptive LSH. Whereas these methods are based on likelihood criteria that a given bucket contains query results, we define a more reliable a posteriori model taking account some prior about the queries and the searched objects. This prior knowledge allows a better quality control of the search and a more accurate selection of the most probable buckets. We implemented a nearest neighbors search based on this paradigm and performed experiments on different real visual features datasets. We show that our a posteriori scheme outperforms other multi-probe LSH while offering a better quality control. Comparisons to the basic LSH technique show that our method allows consistent improvements both in space and time efficiency.
Oxidative Carbon−Carbon Bond Cleavage of a [2.2]Paracyclophane Derivative − Efficient Intramolecular Trapping of the Radical Cation (2000)

4-(2,3,4,5-Tetraphenyl)phenyl[2.2]paracyclophane (3) has been prepared by cycloaddition of tetracyclone (2) to 4-ethynyl[2.2]paracyclophane (1). On treatment with FeCl3 or AlCl3 or NOBF4 in nitromethane, 3 undergoes C−C bond cleavage by an electron transfer process to provide the double benzyl radical cation 10. The phenyl groups of the aryl substituent are ideally oriented for intramolecular trapping and, in the presence of the Lewis acids, ring closure to the new phane system 5 takes place in good yield (65%). In the presence of NOBF4, the half-cyclized aldehyde 6 (66%) is produced. For comparison, [2.2]paracyclophane (7) was also treated with the latter one-electron oxidant, providing bibenzyl-4,4′-dicarbaldehyde (8, 30%) and its monooxime 9 (35%). The structures of the new phane systems 3 and 5 have been determined by X-ray structural analysis, and the mechanisms leading to these products are discussed.
Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits (2015)

Treatment of large peripheral nerve damages ranges from the use of an autologous nerve graft to a synthetic nerve growth conduit. Biological grafts, in spite of many merits, show several limitations in terms of availability and donor site morbidity, and outcomes are suboptimal due to fascicle mismatch, scarring, and fibrosis. Tissue engineered nerve graft substitutes utilize polymeric conduits in conjunction with cues both chemical and physical, cells alone and or in combination. The chemical and physical cues delivered through polymeric conduits play an important role and drive tissue regeneration. Electrical stimulation (ES) has been applied toward the repair and regeneration of various tissues such as muscle, tendon, nerve, and articular tissue both in laboratory and clinical settings. The underlying mechanisms that regulate cellular activities such as cell adhesion, proliferation, cell migration, protein production, and tissue regeneration following ES is not fully understood. Polymeric constructs that can carry the electrical stimulation along the length of the scaffold have been developed and characterized for possible nerve regeneration applications. We discuss the use of electrically conductive polymers and associated cell interaction, biocompatibility, tissue regeneration, and recent basic research for nerve regeneration. In conclusion, a multifunctional combinatorial device comprised of biomaterial, structural, functional, cellular, and molecular aspects may be the best way forward for effective peripheral nerve regeneration.
Autonomic parallel Data Stream Processing (2014)

Data Stream Processing (DaSP) is a recent and highly active research field, applied in various real world scenarios. Differently than traditional applications, input data is seen as transient continuous streams that must be processed “on the fly”, with critical requirements on throughput, latency and memory occupancy. A parallel solution is often advocated, but the problem of designing and implementing high throughput and low latency DaSP applications is complex per se and because of the presence of multiple streams characterized by high volume, high velocity and high variability. Moreover, parallel DaSP applications must be able to adapt themselves to data dynamics in order to satisfy desired QoS levels. The aim of our work is to study these problems in an integrated way, providing to the programmers a methodological framework for the parallelization of DaSP applications.
Evaluation of the effect of CaCl2 and alginate concentrations and hardening time on the characteristics of Lactobacillus acidophilus loaded alginate beads using response surface analysis (2012)

Among alginate and CaCl2 concentrations as well as hardening times, alginate concentration was the most variable in the characteristics of Alginate beads.
Towards high capacity latex-coated porous polymer monoliths as ion-exchange stationary phases (2005)

The preparation of high capacity agglomerated monolithic ion-exchangers for capillary ion chromatography is described. Post-modification of reactive monoliths was investigated as an alternative to co-polymerisation of a suitable functional monomer with an overarching goal of increasing ion-exchange capacity. Direct sulfonation of poly styrene-co-divinyl benzene monoliths using concentrated sulfuric acid or chlorosulfonic acid was unsuccessful even for monoliths containing as low as 8% crosslinker. In contrast, chemical transformation of reactive monoliths containing glycidyl methacrylate was used to increase the ion-exchange capacity by up to more than thirty-fold with ion exchange capacities of 14-29 microequiv g(-1) achieved. Three different reactions were considered, including reaction with 4-hydroxybenenesulfonic acid under basic conditions; reaction with thiobenzoic acid followed by transformation to a reactive thiol and the subsequent oxidation to the sulfonic acid; and direct sulfonation with sodium sulfite. Of these, the reaction with sodium sulfite resulted in the most significant increase in the capacity and the best separation performance. In the isocratic mode separation efficiencies of over 13,500 plates m(-1) were observed (for iodate). The separation of seven inorganic anions was also demonstrated using a hydroxide gradient.
Historical Development of Flame Excitation Sources for Analytical Spectroscopy (1986)

In 1556 Georgius Agricola wrote, in his De Re Metallica, about the colour of fumes from various types of ores. This may be the earliest record available in which the color of a flame-excited metal sample was used to identify a substance. If so, it represents the start of flame spectroscopy as an analytical tool.
Effects of Concentrations on the Transdermal Permeation Enhancing Mechanisms of Borneol: A Coarse-Grained Molecular Dynamics Simulation on Mixed-Bilayer Membranes (2016)

Borneol is a natural permeation enhancer that is effective in drugs used in traditional clinical practices as well as in modern scientific research. However, its molecular mechanism is not fully understood. In this study, a mixed coarse-grained model of stratum corneum (SC) lipid bilayer comprised of Ceramide-N-sphingosine (CER NS) 24:0, cholesterol (CHOL) and free fatty acids (FFA) 24:0 (2:2:1) was used to examine the permeation enhancing mechanism of borneol on the model drug osthole. We found two different mechanisms that were dependent on concentrations levels of borneol. At low concentrations, the lipid system maintained a bilayer structure. The addition of borneol made the lipid bilayer loosen and improved drug permeation. The "pull" effect of borneol also improved drug permeation. However, for a strongly hydrophobic drug like osthole, the permeation enhancement of borneol was limited. When most borneol molecules permeated into bilayers and were located at the hydrophobic tail region, the spatial competition effect inhibited drug molecules from permeating deeper into the bilayer. At high concentrations, borneol led to the formation of water pores and long-lived reversed micelles. This improved the permeation of osthole and possibly other hydrophobic or hydrophilic drugs through the SC. Our simulation results were supported by Franz diffusion tests and transmission electron microscope (TEM) experiments.
Application of health card service pattern in community health services (2009)

Objective
To discuss the effects of the health card-based services on community chronic disease management and the utility of community healthcare resources.


Methods
Follow-up investigation on utilization and satisfaction of card-based health services and coverage of chronic illness management was conducted among cardholder living at Dongcheng District of Beijing during July 1, 2006 and December 31, 2008.


Results
The rates of attendance and health education increased from 47.20% or 1.16% to 90.90% and 46.38%, respectively.The coverage of high blood pressure management and standard hypertension management increased from 47.16% or 45.66% to 80.39% and 78.27%, respectively.The satisfaction of cardholder residents with community healthcare services was improved year by year.


Conclusions
The health card service pattern plays a significant role in improving chronic disease management, which results in more satisfaction with and utilization of healthcare resources in community.


Key words: 
Community health services; Health education; Chronic disease
A clinically relevant review of tizanidine hydrochloride dose relationships to pharmacokinetics, drug safety and effectiveness in healthy subjects and patients (2008)

There is substantial evidence to show that plasma tizanidine concentrations are linearly related to dose in healthy subjects and patients, although there is a high degree of intersubject variability. The most common adverse events and pharmacodynamic effects are related to plasma concentrations. The clinical implications of the large interpatient variability in plasma tizanidine concentrations and its narrow therapeutic index make it necessary to individualise patient therapy. Practical advice on tizanidine dosing and/or switching between formulations is provided.
Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity (2012)

Secondary lymphoid organs (SLOs), including lymph nodes, Peyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen-presenting cells for cognate antigens, while moving along stromal networks. The cell-cell interactions between stromal and hematopoietic cells in SLOs are therefore integral to the normal functioning of these tissues. Not only do stromal cells physically construct SLO architecture but they are essential for regulating hematopoietic populations within these domains. Stromal cells interact closely with lymphocytes and dendritic cells, providing scaffolds on which these cells migrate, and recruiting them into niches by secreting chemokines. Within lymph nodes, stromal cell-ensheathed conduit networks transport small antigens deep into the SLO parenchyma. More recently, stromal cells have been found to induce peripheral CD8(+) T-cell tolerance and control the extent to which newly activated T cells proliferate within lymph nodes. Thus, stromal-hematopoietic crosstalk has important consequences for regulating immune cell function within SLOs. In addition, stromal cell interactions with hematopoietic cells, other stroma, and the inflammatory milieu have profound effects on key stromal functions. Here, we examine ways in which these interactions within the lymph node environment influence the adaptive immune response.
Flow cytometric analysis of androgen receptor expression in human prostate tumors and benign tissues. (2000)

Androgen receptor (AR) plays an important role in growth and hormonal therapy of human prostate tumors. Immunohistochemical analysis of AR expression, a nonquantitative technique, is currently used for screening of receptor expression in prostate tissues. The present report describes a laser flow cytometric method for monitoring AR expression in human cell lines and in archival formalin-fixed paraffin-embedded prostate tissues and tumors. Multiparametric flow analysis can be used for simultaneous detection of other cellular markers (e.g., DNA aneuploidy), and by gated analysis, AR expression in subpopulations of a tumor can be quantitatively determined.
Laboratory Diagnosis of Urinary Tract Infections in Adult Patients (2004)

Urinary tract infections (UTIs) are among the most common bacterial infections and account for a significant part of the workload in clinical microbiology laboratories. Enteric bacteria (in particular, Escherichia coli) remain the most frequent cause of UTIs, although the distribution of pathogens that cause UTIs is changing. More important is the increase in resistance to some antimicrobial agents, particularly the resistance to trimethoprim-sulfamethoxazole seen in E. coli. Physicians distinguish UTIs from other diseases that have similar clinical presentations with use of a small number of tests, none of which, if used individually, have adequate sensitivity and specificity. Among the diagnostic tests, urinalysis is useful mainly for excluding bacteriuria. Urine culture may not be necessary as part of the evaluation of outpatients with uncomplicated UTIs, but it is necessary for outpatients who have recurrent UTIs, experience treatment failures, or have complicated UTIs, as well as for inpatients who develop UTIs.
Dynamic element matching techniques for data converters (2019)

Analog to digital converter (ADC) circuit component errors create nonuniform quantization code widths and create harmonic distortion in an ADC's output. In this dissertation, two techniques for estimating an ADC's output spectrum from the ADC's transfer function are determined. These methods are compared to a symmetric power function and asymmetric power function approximations. Standard ADC performance metrics, such as SDR, SNDR, SNR, and SFDR, are also determined as a function of the ADC's transfer function approximations. New dynamic element matching (DEM) flash ADCs are developed. An analysis of these DEM flash ADCs is developed and shows that these DEM algorithms improve an ADC's performance. The analysis is also used to analyze several existing DEM ADC architectures; Digital to analog converter (DAC) circuit component errors create nonuniform quantization code widths and create harmonic distortion in a DAC's output. In this dissertation, an exact relationship between a DAC's integral nonlinearity (INL) and its output spectrum is determined. Using this relationship, standard DAC performance metrics, such as SDR, SNDR, SNR, and SFDR, are calculated from the DAC's transfer function. Furthermore, an iterative method is developed which determines an arbitrary DAC's transfer function from observed output magnitude spectra. An analysis of DEM techniques for DACs, including the determination of several suitable metrics by which DEM techniques can be compared, is derived. The performance of a given DEM technique is related to standard DAC performance metrics, such as SDR, SNDR, and SFDR. Conditions under which DEM techniques can guarantee zero average INL and render the distortion due to mismatched components as white noise are developed. Several DEM circuits proposed in the literature are shown to be equivalent and have hardware efficient implementations based on multistage interconnection networks. Example DEM circuit topologies and their hardware efficient VLSI implementations are also presented.
Spectral Analysis (1999)

Abstract The sections in this article are Nonparametric Methods for Spectral Estimation Parametric Methods for Rational Spectral Estimation Parametric Methods for Sinusoidal Spectral Estimation Applications To Time‐Varying Signal Spectral Analysis