gebhart/patrepeval huggingface dataset:
SURGICAL REVISION AFTER FAILURE OF THE GLENOID COMPONENT OF SHOULDER PROSTHESES: 16 CASES (2004)

Purpose: Failure of the glenoid component is the main complication of total shoulder prostheses. When surgical revision is necessary, the surgeon has the option of a new implantation or non-prosthetic plasty (glenoido-plasty). The purpose of the present work was to analyse results obtained with these two techniques in order to propose proper indications. Material and methods: This retrospective study included 16 patients, mean age 62 years at revision surgery. Fialures included loosening of a cemented glenoid implant (n=9) and failure of non-cemented implants (3 defective anchors, 4 unclipped polyethylene inserts). Mean time to revision was 39 months (2–178) after primary implantation. A new glenoid implant was cemented in nine patients (group A). Seven patients (group 2) had glenoidoplasty with an iliac graft in four. Results: A mean follow-up of 37 months (19–73), the Constant score had improved from 18 points before revision to 52 points (+34). Two patients experienced a complication requiring a second revision (infection, instability) and one patient underwent subsequent surgery for biceps tenodesis. For the group with glenoidoplasty with iliac graft, insertion of an inverted prosthesis was achieved during a second operative time. In group 1, the mean Constant score at last-follow-up was 63 points (+45) with the pain score of 11, movement score of 29. In group 2, the mean Constant score was 37 (+19) with pain at 6 and motion at 16. In this group, the mean score was 48 points with a glenoid graft and 21 points with simple implant replacement. Discussion: Revision surgery for a failed glenoid implant remains a difficult procedure but can be effective for pain relief and improved motion score. The small number of patients in this series makes it difficult to perform statistical analysis but the results do point in favour of prosthetic reimplantation when the bone stock is sufficient. For other patients, a graft would be preferable to simple implant removal. This would allow secondary revision if possible.
Methods and Compositions for Amplification and Detection of microRNAs (miRNAs) and Noncoding RNAs (ncRNAs) Using the Signature Sequence Amplification Method (SSAM) (2014)

The signature sequence amplification method (SSAM) described herein is an approach for amplifying noncoding RNA (ncRNA), microRNA (miRNA), and small polynucleotide sequences. A key point of the SSAM technology is the generation of signature sequences. The signature sequences include target sequences (miRNA, ncRNA, and/or any small polynucleotide sequence) flanked by two DNA fragments. Target sequences can be amplified through DNA synthesis, RNA synthesis, or the combination of DNA and RNA synthesis. The amplification of signature sequences provides an efficient and reproducible mechanism to determine the presence or absence of the target miRNAs/ncRNAs, to analyze the quantities of the miRNAs in biological samples, and for miRNA/ncRNA profiling.
Reduction of Tissue Plasminogen Activator-Induced Hemorrhage and Brain Injury by Free Radical Spin Trapping after Embolic Focal Cerebral Ischemia in Rats (2000)

Thrombolytic stroke therapy with tissue plasminogen activator (tPA) remains complicated by serious risks of cerebral hemorrhage and brain injury. In this study, a novel model of tPA-induced hemorrhage was used in spontaneously hypertensive rats to examine the correlates of hemorrhage, and test methods of reducing hemorrhage and brain injury. Homologous blood clot emboli were used to occlude the middle cerebral artery in spontaneously hypertensive rats, and delayed administration of tPA (6 hours postischemia) resulted in high rates of cerebral hemorrhage 24 hours later. Compared with untreated rats, tPA significantly increased hemorrhage volumes by almost 85%. Concomitantly, infarction and neurological deficits were worsened by tPA. A parallel experiment in normotensive Wistar-Kyoto rats showed markedly reduced rates of hemorrhage, and tPA did not significantly increase hemorrhage volumes. To examine whether tPA-induced hemorrhage was caused by the delayed onset of reperfusion per se, another group of spontaneously hypertensive rats was subjected to focal ischemia using a mechanical method of arterial occlusion. Delayed (6 hours) reperfusion via mechanical means did not induce hemorrhage. However, administration of tPA plus delayed mechanical reperfusion significantly increased hemorrhage volumes. Since reperfusion injury was implicated, a final experiment compared outcomes in spontaneously hypertensive rats treated with tPA plus the free radical spin trap alpha-phenyl tert butyl nitrone (alpha-PBN) versus tPA alone. tPA-induced hemorrhage volumes were reduced by 40% with alpha-PBN, and infarction and neurological deficits were also decreased. These results indicate that (1) blood pressure is an important correlate of tPA-induced hemorrhage, (2) tPA interacts negatively with reperfusion injury to promote hemorrhage, and (3) combination therapies with anti-free radical treatments may reduce the severity of tPA-induced hemorrhage and brain injury after cerebral ischemia.
Development of a Potent and Selective HDAC8 Inhibitor (2016)

A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.
Embeddable Automatic Polyp Detection for Videoendoscopy and Wireless Videoendoscopy Images Analysis (2012)

International audience
Amorphous fluoropolymer: next-generation optical coating candidate (1994)

Anti-reflective (AR) and high reflector (HR) optical coatings were made by physical vapor deposition (PVD) of Teflon AF2400, a perfluorinated amorphous polymer. The AR had the highest laser damage thresholds recorded for PVD coatings at the Lawrence Livermore National Laboratory damage facility. The HR was a multilayer of ZnS and AF2400. The bandwidth was 550 nm, centered at 1064 nm. Single layers of Teflon AF2400 deposited by PVD were characterized optically. The refractive index could be intentionally reduced below the bulk value by varying either deposition rate or substrate temperature. Scanning electron microscopy and nuclear magnetic resonance observations indicated that morphological changes caused the variations in the refractive index rather than compositional changes.
Designing and Comparing Optimised Pseudo-Continuous Arterial Spin Labelling Protocols for Measurement of Cerebral Blood Flow (2020)

1. Abstract Arterial Spin Labelling (ASL) is a non-invasive, non-contrast, perfusion imaging technique which is inherently SNR limited. It is, therefore, important to carefully design scan protocols to ensure accurate measurements. Many pseudo-continuous ASL (PCASL) protocol designs have been proposed for measuring cerebral blood flow (CBF), but it has not yet been demonstrated which design offers the most accurate and repeatable CBF measurements. In this work, a wide range of literature PCASL protocols, including single-delay, sequential and time-encoded multi-timepoint protocols, and several novel protocol designs, which are hybrids of time-encoded and sequential multi-timepoint protocols, were first optimised using a Cramér-Rao Lower Bound framework and then compared for CBF accuracy and repeatability using Monte Carlo simulations and in vivo experiments. It was found that several multi-timepoint protocols produced more confident, accurate, and repeatable CBF estimates than the single-delay protocol, while also generating maps of arterial transit time. One of the novel hybrid protocols, Hybrid T1 -adj , was found to produce the most confident, accurate and repeatable CBF estimates of all protocols tested in both simulations and in vivo (24%, 47%, and 28% more confident, accurate, and repeatable than single-PLD in vivo). The Hybrid T1 -adj protocol makes use of the best aspects of both time-encoded and sequential multi-timepoint protocols and should be a useful tool for accurately and efficiently measuring CBF.
A Generalized and Automatic Image Contrast Enhancement Using Gray Level Grouping (2006)

Contrast enhancement has an important role in image processing applications. Conventional contrast enhancement techniques either fail to produce satisfactory results for a broad variety of low-contrast images, or cannot be automatically applied to different images, because their parameters must be specified manually to produce a satisfactory result for a given image. This paper describes a new automatic method for contrast enhancement. The basic procedure is to first group the histogram components of a low-contrast image into the proper number of bins according to a selected criterion, then redistribute these bins uniformly over the grayscale, and finally ungroup the previously grouped gray-levels. Accordingly, this new technique is named gray-level grouping (GLG). GLG not only produces results superior to conventional contrast enhancement techniques, but is also fully automatic in most circumstances, and is applicable to a broad variety of images
Readily accessible heteroaromatic silanes as fluoride acceptors in a mild ^(18)F-^(19)F isotopic exchange (2015)

Silicon fluoride acceptors (SiFAs) are under study as new imaging agents useful for positron emission tomography (PET).[1] They are readily labeled with the radioisotope flourine-18 via a fast and mild ^(18)F–^(19)F isotopic exchange reaction (IEX).[2] The application of SiFA-based PET probes has been hampered by their high intrinsic lipophilicity, originating from bulky tert-butyl groups required for in vivo stabilization of the Si–^(18)F bond. Herein, we present the first example of ^(18)F–labeled N- and S-heteroaromatic SiFAs with improved lipophilicity. Furthermore, we demonstrate that simple cartridge-based purification is sufficient, which avoids the usual time-consuming HPLC step.
Ultrasonic Preparation of Porous Silica-Dye Microspheres: Sensors for Quantification of Urinary Trimethylamine <i>N</i>-Oxide (2018)

Trimethylamine N-oxide (TMAO), the N-oxide metabolite of trimethylamine (TMA), is a key index in the determination of a wide variety of human cardiac or kidney diseases. A colorimetric sensor array comprising ultrasonically prepared silica-dye microspheres was developed for rapid, portable, and sensitive detection of urinary TMAO. To prepare the sensor array, 13 different organically modified silica (ormosil)-dye composites were synthesized from the hydrolysis/pyrolysis of ultrasonically sprayed organosiloxane precursors under optimized reaction conditions; the resulting products are uniformly sized nanoporous microspheres that are effective colorimetric sensors for various volatile analytes. The effective quantification of aqueous TMAO (which is not volatile) was based on sensing the volatile TMA produced from a simple catalytic reduction of TMAO in situ. RGB color-change patterns from digital images of the sensor array permit precise discrimination among a wide range of TMAO concentrations (10-750 μM) in simulated urine samples; both hierarchical cluster analysis and principal component analysis achieve >99% accuracy in data classification. The calculated limit of detection of urinary TMAO is ∼4 μM, which is substantially below the median level of healthy subjects (∼380 μM). The array of sensors could be simplified to only a couple of strongly responsive elements for the ease of field use, and the process could be developed as a point-of-care tool in combination with digital imaging for the early diagnosis of cardiovascular or kidney diseases from the measurement of fasting urinary level of TMAO.
Adapting grapheme-to-phoneme conversion for name recognition (2007)

This work investigates the use of acoustic data to improve grapheme-to-phoneme conversion for name recognition. We introduce a joint model of acoustics and graphonemes, and present two approaches, maximum likelihood training and discriminative training, in adapting graphoneme model parameters. Experiments on a large-scale voice-dialing system show that the maximum likelihood approach yields a relative 7% reduction in SER compared to the best baseline result we obtained without leveraging acoustic data, while discriminative training enlarges the SER reduction to 12%.
Analysis of the interaction of procathepsin D activation peptide with breast cancer cells (1997)

Cathepsin D, a lysosomal aspartic proteinase, is secreted in the form of enzymatically inactive proenzyme by many types of human breast cancer tissue and exerts mitogenic activity toward these tissues. Flow cytometry was used to test the binding of procathepsin D purified from the secretion of the breast cancer cell line ZR-75-1 to human breast cancer cells. No previously known surface antigens or soluble M6P-R or anti-M6P-R antibodies were found to inhibit the specific binding of procathepsin D-FITC. Similarly, none of these potential inhibitors was found to inhibit growth factor activity of procathepsin D. Our results indicate that procathepsin D growth factor activity is mediated by a new, previously unknown receptor moiety and that the binding activity can be localized in position 27-44 of the activation peptide of procathepsin D. Furthermore, in vivo experiments indicate that treatment with anti-procathepsin D antibodies can reverse the growth of human breast tumors in athymic nude mice.
Crystal Structure of Farnesyl Protein Transferase Complexed with a CaaX Peptide and Farnesyl Diphosphate Analogue (1998)

The crystallographic structure of acetyl-Cys-Val-Ile-selenoMet-COOH and alpha-hydroxyfarnesylphosphonic acid (alphaHFP) complexed with rat farnesyl protein transferase (FPT) (space group P61, a = b = 174. 13 A, c = 69.71 A, alpha = beta = 90 degrees, gamma = 120 degrees, Rfactor = 21.8%, Rfree = 29.2%, 2.5 A resolution) is reported. In the ternary complex, the bound substrates are within van der Waals contact of each other and the FPT enzyme. alphaHFP binds in an extended conformation in the active-site cavity where positively charged side chains and solvent molecules interact with the phosphate moiety and aromatic side chains pack adjacent to the isoprenoid chain. The backbone of the bound CaaX peptide adopts an extended conformation, and the side chains interact with both FPT and alphaHFP. The cysteine sulfur of the bound peptide coordinates the active-site zinc. Overall, peptide binding and recognition appear to be dominated by side-chain interactions. Comparison of the structures of the ternary complex and unliganded FPT [Park, H., Boduluri, S., Moomaw, J., Casey, P., and Beese, L. (1997) Science 275, 1800-1804] shows that major rearrangements of several active site side chains occur upon substrate binding.
Theory of quantum imaging with undetected photons (2015)

A novel quantum imaging technique has recently been demonstrated in an experiment, where the photon used for illuminating an object is not detected; the image is obtained by interfering two beams, none of which ever interacts with the object. Here we present a detailed theoretical analysis of the experiment. We show that the object information is present only in the interference term and not in the individual intensities of the interfering beams. We also theoretically establish that the magnification of the imaging system depends on two wavelengths: the average wavelength of the photon that illuminates the object and the average wavelength of the photon that is detected. Our analysis affirms that the imaging process is based on the principle that quantum interference occurs when interferometric path information is unavailable.
Detoxification spectrum of the cigarette beetle symbiont <i>Symbiotaphrina kochii</i> in culture (1991)

Abstract The ability of cultures of the cigarette beetle symbiont, Symbiotaphrina kochii Jurzitza ex. W. Gams and v. Arx, to utilize toxins as carbon sources and produce detoxifying enzymes was tested. This yeast could apparently use many of the plant allelochemicals, meal toxins, mycotoxins, insecticides, and herbicides tested as carbon sources, suggesting the ability to detoxify these compounds. Detoxifying enzymes that were detected using representative substrates included aromatic ester hydrolase, glucosidase, phosphatase, and glutathione transferase. This yeast was also able to hydrolyze the organophosphorus insecticide parathion. Thus, this yeast appears to have broad‐spectrum detoxifying capabilities. Either this strain of yeast, improved strains, or other microorganisms to which genetic material from this yeast has been transferred may be of use in decontaminating materials containing multiple toxins.
Morphing Segmented Wind Turbine Concept (2010)

A morphing segmented concept is proposed herein for future extreme-scale wind turbine systems. The morphing may be accomplished by using segmented blades connected by screw sockets and a tension cable system. At low wind and rotor speeds, the segmented blades are fully tensioned and set at high pitch to ensure start-up and maximum power at low speeds. At high rotor rpm, the cable tension can be designed such that centrifugal forces drive the blade segments outward so as to unwind/feather the rotor and prevent over-speed. This effectively acts like a passive pitch control for rotor speeds. Perhaps more importantly, the airfoils of the blade segments can be designed with a center of pressure downstream of the socket axis. This will cause an aerodynamic moment at high wind speeds which will serve to unwind the blade segments to prevent torque spikes and blade stall. For a given rotor diameter and torque, such stall prevention can permit operation at higher average lift coefficient with a reduced blade chord length which can reduce blade and overall system weight. In addition, the segmented blade concept can alleviate manufacturing and shipping constraints for extreme-scale systems. In the proposed concepts, the bending loads will be carried by the segmented rotor spar and not the blade skin. This will result in much larger downstream deflections of the blades at high wind speeds as compared to that of a conventional rigid single-piece turbine blade. Therefore, a downstream design would be needed to avoid potential strike of the blades with the tower. This will require a more aerodynamic tower to reduce wake interactions but a downstream system may eliminate yaw-control and substantially relax blade rigidity constraints, thus further reducing blade weight. However, this morphing concept faces several technical challenges including substantially increased susceptibility to flutter instability and dynamic stall which is expected to require active control systems.
Automated Synthesis by Means of Genetic Programming of Human- Competitive Designs Employing Reuse, Hierarchies, Modularities, Development, and Parameterized Topologies (2003)

Genetic programming can be used as an automated invention machine to create designs. Genetic programming has automatically created designs that infringe, improve upon, or duplicate the functionality (in a novel way) of 16 previously patented inventions involving circuits, controllers, and mathematical algorithms. Genetic programming has also generated two patentable new inventions for which patent applications have been filed. Genetic programming has also generated numerous other human-competitive results, including the design of quantum computing circuits that are superior to those designed by human designers. Genetic programming has also designed antennae, networks of chemical reactions (metabolic pathways), and genetic networks. Genetic programming can automatically create hierarchies, automatically identify and reuse modulatitles, automatically determine program architecture, and automatically create parameterized topologies. When genetic programming is used to design complex structures, it is often advantageous to use a developmental process that enables syntactic validity and locality to be preserved under crossover.
Inductive-detection electron-spin resonance spectroscopy with 65 spins/root Hz sensitivity (2017)

We report electron spin resonance spectroscopy measurements performed at millikelvin temperatures in a custom-built spectrometer comprising a superconducting micro-resonator at 7 GHz and a Josephson parametric amplifier. Owing to the small (∼10−12λ3∼10−12λ3) magnetic resonator mode volume and to the low noise of the parametric amplifier, the spectrometer's single shot sensitivity reaches 260 ± 40 spins/echo translating into 65±10 spins/Hz⎯⎯⎯⎯⎯√65±10 spins/Hz for repeated acquisition.
Automatic polyp detection in colonoscopy videos (2017)

Colon cancer is the second cancer killer in the US [1]. Colonoscopy is the primary method for screening and prevention of colon cancer, but during colonoscopy, a significant number (25% [2]) of polyps (precancerous abnormal growths inside of the colon) are missed; therefore, the goal of our research is to reduce the polyp miss-rate of colonoscopy. This paper presents a method to detect polyp automatically in a colonoscopy video. Our system has two stages: Candidate generation and candidate classification. In candidate generation (stage 1), we chose 3,463 frames (including 1,718 with-polyp frames) from real-time colonoscopy video database. We first applied processing procedures, namely intensity adjustment, edge detection and morphology operations, as pre-preparation. We extracted each connected component (edge contour) as one candidate patch from the pre-processed image. With the help of ground truth (GT) images, 2 constraints were implemented on each candidate patch, dividing and saving them into polyp group and non-polyp group. In candidate classification (stage 2), we trained and tested convolutional neural networks (CNNs) with AlexNet architecture [3] to classify each candidate into with-polyp or non-polyp class. Each with-polyp patch was processed by rotation, translation and scaling for invariant to get a much robust CNNs system. We applied leave-2-patients-out cross-validation on this model (4 of 6 cases were chosen as training set and the rest 2 were as testing set). The system accuracy and sensitivity are 91.47% and 91.76%, respectively.
Enhancement of site selection diversity transmit power control in CDMA cellular systems (2002)

In CDMA cellular systems, site selection diversity transmit (SSDT) power control is employed during soft handover to reduce interference in the downlink. In SSDT, mobile stations select a cell from active cells during soft handover based on the received power of common pilot signals. The selected cells transmit data signals, and the other cells suspend transmission of data signals. We introduce multiple-SSDT as a natural extension of SSDT, and three approaches to enhance the performance of SSDT are presented. With the enhancements, it is possible to eliminate residual frame errors, and to optimize the measurement period of common pilot signals. Also it is possible to reduce interference with efficient transmission of control signals.
A Heterogeneous Silicon on Lithium Niobate Modulator for Ultra-Compact and High-Performance Photonic Integrated Circuits (2021)

We propose a heterogeneous silicon on lithium niobate (Si-LN) modulator which improves the compactness and modulating performance of large-scale photonic integrated circuits. Two types of configurations are employed on the Si-LN wafer for ultra-compact light-routing waveguides and high-performance light-modulating waveguides, respectively. The low loss taper transfers the optical modes between the two waveguides. In the heterogeneous Si-LN modulator, LN etching is nonessential and thus device processes are supported on a robust wafer. Our design analyzes the influence of the LN thickness on the performance. According to theoretical analysis and numerical simulation, the modulator supports a bend radius of 10 μm and edge-to-edge waveguide separation of 0.7 μm with respect to ∼1 cm beat length. When thickness of LN is 700 nm, the modulation efficiency reaches 1.76 V⋅cm and the bandwidth exceeds 350 GHz. This modulator is potentially suitable for ultra-compact, large-scale, high efficiency, and large bandwidth photonic integrated circuits (PICs).