gebhart/patrepeval huggingface dataset:
NPS CubeSat Launcher Program Management (2009)

Residual and physiological functional strains in soft tissues are known to play an important role in modulating organ stress distributions. Yet, no known comprehensive information on residual strains exist, or non-invasive techniques to quantify in-vivo deformations for the aortic valve (AV) leaflets. Herein we present a completely non-invasive approach for determining heterogeneous strains - both functional and residual - in semilunar valves and apply it to normal human AV leaflets. Transesophageal 3D echocardiographic (3DE) images of the AV were acquired from open-heart transplant patients, with each AV leaflet excised after heart explant and then imaged in a flattened configuration ex-vivo. Using an established spline parameterization of both 3DE segmentations and digitized ex-vivo images (Aggarwal et al., 2014), surface strains were calculated for deformation between the ex-vivo and three in-vivo configurations: fully open, just-coapted, and fully-loaded. Results indicated that leaflet area increased by an average of 20% from the ex-vivo to in-vivo open states, with a highly heterogeneous strain field. The increase in area from open to just-coapted state was the highest at an average of 25%, while that from just-coapted to fully-loaded remained almost unaltered. Going from the ex-vivo to in-vivo mid-systole configurations, the leaflet area near the basal attachment shrank slightly, whereas the free edge expanded by ~10%. This was accompanied by a 10° -20° shear along the circumferential-radial direction. Moreover, the principal stretches aligned approximately with the circumferential and radial directions for all cases, with the highest stretch being along the radial direction. Collectively, these results indicated that even though the AV did not support any measurable pressure gradient in the just-coapted state, the leaflets were significantly pre-strained with respect to the excised state. Furthermore, the collagen fibers of the leaflet were almost fully recruited in the just-coapted state, making the leaflet very stiff with marginal deformation under full pressure. Lastly, the deformation was always higher in the radial direction and lower along the circumferential one, the latter direction made stiffer by the preferential alignment of collagen fibers. These results provide significant insight into the distribution of residual strains and the in-vivo strains encountered during valve opening and closing in AV leaflets, and will form an important component of the tool that can evaluate valve׳s functional properties in a non-invasive manner.
Synthesis and characterization of BPA-free polyesters by incorporating a semi-rigid cyclobutanediol monomer (2020)

A <italic>trans</italic>-1,3-cyclobutane-containing diol (<bold>CBDO-1</bold>) has been synthesized and introduced to materials science as a versatile monomer and a possible phenol-free BPA replacement.
Geometry Definition and Contact Analysis of Spherical Involute Straight Bevel Gears (2012)

A practical application of the spherical involute surface to the forged straight bevel gears is provided and demonstrated in this work. Conjugate (pure involute) theoretical surfaces are developed from the input design parameters. The surfaces are modified to suit the actual application (automotive differential). The unloaded (or low load) tooth contact analysis of modified surfaces is performed to obtain the prediction of the contact pattern. In order to verify the procedure and predictions, actual straight bevel gears are forged by using provided surfaces, and their contact pattern is compared to the predictions. Influence of the misalignments on the gear performance is investigated in order to provide more robust design.
Rhombohedral–Tetragonal Phase Boundary with High Curie Temperature in (1-x)BiCoO<sub>3</sub>–xBiFeO<sub>3</sub> Solid Solution (2008)

The crystal structure change of the solid solution BiCo1-xFexO3 was investigated in order to determine the phase boundary between tetragonal BiCoO3 and rhombohedral BiFeO3. It was found that BiCo1-xFexO3 with x = 0 to 0.6 had tetragonal BiCoO3 structures, while those with x = 0.8 to 1 had rhombohedral BiFeO3 structures at room temperature. The monoclinic √2a ×√2a ×a phase was found for the x = 0.7 sample. The tetragonal-to-cubic phase transition was first observed at around 700–850 °C in Bi-based perovskite for the x = 0.8 sample.
An Innovative Approach to Permanent State Funding of Civil Legal Services: One State's Experience-So Far (1998)

In October 1997 the Chief Judge of the State of New York, Judith S. Kaye, appointed a Legal Services Project and charged its members with finding a means of "promot[ing] constancy in the flow of resources for professional legal services organizations so that they may continue their excellent work and serve greater numbers of litigants." At the time of announcing the project, Chief Judge Kaye stated: "A justice system that allows disparities in justice based on the ability to pay is inconsistent with a fundamental principle of our free democratic society - equal justice for all." The Project therefore viewed its mandate as identifying a potential source of permanent state funding for civil legal services programs - one that would be "substantial, stable from year to year, and secure (that is, permanent).
The double mask‐a new local scavenging system for anaesthetic gases and volatile agents (1986)

The double mask, a new concept for local scavenging of anaesthetic gases escaping around face masks and from endotracheal tubes, is described. The system consists of a flexible silicone mask into which the anaesthetic gas mixture is led through a flow distributor which is necessary for adequate scavenging. A rigid transparent polysulphone shell surrounds the inner mask, and escaping gas is evacuated via the 3-4 mm slot between the two masks by a fan, centrally located outside the operating-room. With this system, the anaesthetist's exposure to nitrous oxide during mask anaesthesia was reduced from 145 +/- 29 to 15 +/- 3 ppm (mean +/- s.e. mean, P less than 0.001) and to halothane from 2.9 +/- 1.1 to 0.5 +/- 0.1 ppm (mean +/- s.e. mean, P less than 0.05), as measured in 32 patients aged 1-74 years. The double-mask system provided safe and adequate mask anaesthesia, as judged from inspired concentrations of anaesthetic and fresh gases and transcutaneous and blood gases in 24 patients. The noise level was low with a mean value under regular operating-room conditions around 45 dB(A) in the low frequency range. It is concluded that using the scavenging conditions provided by the system, the Swedish limits for anaesthesiologists' gas exposure could be reduced to the levels recommended by the US National Institute of Occupational Safety and Health (25 ppm for nitrous oxide and 0.5 ppm for halothane).
Excimer-laser-induced etching of ceramic PbTi1−<i>x</i>Zr<i>x</i>O3 (1987)

The etching of ceramic PbTi1−xZrxO3 (PZT) by XeCl excimer laser radiation has been investigated. In air, the threshold fluence for etching was about 2 J/cm2. At fluences of 10 J/cm2, etch rates of 0.1 μm/pulse were observed. The geometry of etched structures can readily be defined by choosing suitable experimental conditions, suggesting potential applications of this process to the production of devices.
Efficacy and tolerability of DHEP-heparin plaster in reducing pain in mild-to-moderate muscle contusions: a double-blind, randomized trial (2012)

The DHEP-heparin plaster is superior to the reference DHEP plaster in reducing pain associated with mild-to-moderate muscle contusion. Both active treatments were significantly more effective than placebo, and each showed a comparably favorable, placebo-like safety profile.
Effects of caloric vestibular stimulation on serotoninergic system in the media vestibular nuclei of guinea pigs (2007)

Neither somato-sensory stimulation of the middle ear nor nonspecific cold or hot stress affects the serotonin release. The rise of 5-HT in MVN may be involved in the mechanism of vertigo induced by caloric stimulation.
Complexation of C<sub>60</sub> on a Cyclothiophene Monolayer Template (2006)

Highly ordered monolayers of macrocyclic oligothiophene C[12]T (see Figure) can be used as veritable templates to epitaxially grow 3D nanoarchitectures with C60-fullerenes. Due to submolecularly resolved STM images, 1:1 complexes consisting of a ring-shaped p-type semiconductor (C[12]T) and a spherical n-type semiconductor (C60) can be investigated in terms of dynamics and complexation sites.
Hyaluronan Enhances Bone Marrow Cell Therapy for Myocardial Repair After Infarction (2013)

Hyaluronan (HA) has been shown to play an important role during early heart development and promote angiogenesis under various physiological and pathological conditions. In recent years, stem cell therapy, which may reduce cardiomyocyte apoptosis, increase neovascularization, and prevent cardiac fibrosis, has emerged as a promising approach to treat myocardial infarction (MI). However, effective delivery of stem cells for cardiac therapy remains a major challenge. In this study, we tested whether transplanting a combination of HA and allogeneic bone marrow mononuclear cells (MNCs) promotes cell therapy efficacy and thus improves cardiac performance after MI in rats. We showed that HA provided a favorable microenvironment for cell adhesion, proliferation, and vascular differentiation in MNC culture. Following MI in rats, compared with the injection of HA alone or MNC alone, injection of both HA and MNCs significantly reduced inflammatory cell infiltration, cardiomyocyte apoptosis, and infarct size and also improved cell retention, angiogenesis, and arteriogenesis, and thus the overall cardiac performance. Ultimately, HA/MNC treatment improved vasculature engraftment of transplanted cells in the infarcted region. Together, our results indicate that combining the biocompatible material HA with bone marrow stem cells exerts a therapeutic effect on heart repair and may further provide potential treatment for ischemic diseases.
Low Temperature Growth of SbSI Single Crystals (1981)

Crystallization of SbSI from the vapour phase was investigated. By lowering the growth temperature about 50°C (growing zone: 300°C, source zone: 320°C) than usual method, we could obtain large crystals with mirror-like surfaces and without hollows. The largest surfaces observed on the as-grown crystals were usually characterized by (110) planes. These crystals are suitable for optical measurements such as optical absorption or Raman scattering.
Engineering of Surface Chemistry for Enhanced Sensitivity in Nanoporous Interferometric Sensing Platforms (2017)

We explore new approaches to engineering the surface chemistry of interferometric sensing platforms based on nanoporous anodic alumina (NAA) and reflectometric interference spectroscopy (RIfS). Two surface engineering strategies are presented, namely (i) selective chemical functionalization of the inner surface of NAA pores with amine-terminated thiol molecules and (ii) selective chemical functionalization of the top surface of NAA with dithiol molecules. The strong molecular interaction of Au<sup>3+</sup> ions with thiol-containing functional molecules of alkane chain or peptide character provides a model sensing system with which to assess the sensitivity of these NAA platforms by both molecular feature and surface engineering. Changes in the effective optical thickness of the functionalized NAA photonic films (i.e., sensing principle), in response to gold ions, are monitored in real-time by RIfS. 6-Amino-1-hexanethiol (inner surface) and 1,6-hexanedithiol (top surface), the most sensitive functional molecules from approaches i and ii, respectively, were combined into a third sensing strategy whereby the NAA platforms are functionalized on both the top and inner surfaces concurrently. Engineering of the surface according to this approach resulted in an additive enhancement in sensitivity of up to 5-fold compared to previously reported systems. This study advances the rational engineering of surface chemistry for interferometric sensing on nanoporous platforms with potential applications for real-time monitoring of multiple analytes in dynamic environments.
Diode laser optical recording using trilayer structures (1981)

A new high-power diode laser and a more sensitive trilayer disk structure useful for FM video and digital data recording have been demonstrated. The diode laser is a constricted double-heterojunction large optical cavity (CDH-LOC) device capable of up to 100 mW output power in a single stable mode. By improving the thermal efficiency of the trilayer structure, the sensitivity is improved by a factor of two over previously reported trilayer structures. Digital signals with data rates up to 30 Mbits/s and storage capacity in excess of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3 \times 10^{10}</tex> bits are demonstrated using a plastic 12 in diameter disk rotating at 30 r/s while digital systems with data rates up to 60 Mbits/s and storage capacity in excess of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> bits are shown to be feasible.
Retrospective Evaluation of a New Neonatal Trigger Score (2013)

The NTS observation chart acts as an adjunct to clinical assessment, highlighting unwell neonates. Its simplicity allows successful and safe use by nonpediatric specialists. NTS out-performed PEWS, with significantly better sensitivity, particularly in neonates who deteriorated within the first 12 hours after birth (P < .001) or in neonates with sepsis or respiratory symptoms (P < .001). Neonates with a score of 1 should be reviewed and those scoring ≥2 should be considered for NICU admission for further management.
P‐120: Tight Bonding of Two Plastic Substrates for Flexible LCDs (2007)

Abstract We developed a novel technique to maintain a constant cell gap of the flexible LCD under various external distortions. The two flexible substrates were assembled tightly by the UV curable polymer placed on top of rigid pillar spacer array. In this technique, we designed the columnar micro‐structure to lead the self‐collected construct of adhesive polymer which promotes the good adhesion and high mechanical stability against the external deformations.
Recombinant<i>Mycobacterium bovis</i>BCG Prime-Recombinant Adenovirus Boost Vaccination in Rhesus Monkeys Elicits Robust Polyfunctional Simian Immunodeficiency Virus-Specific T-Cell Responses (2009)

While mycobacteria have been proposed as vaccine vectors because of their persistence and safety, little has been done systematically to optimize their immunogenicity in nonhuman primates. We successfully generated recombinant Mycobacterium bovis BCG (rBCG) expressing simian immunodeficiency virus (SIV) Gag and Pol as multigenic, nonintegrating vectors, but rBCG-expressing SIV Env was unstable. A dose and route determination study in rhesus monkeys revealed that intramuscular administration of rBCG was associated with local reactogenicity, whereas intravenous and intradermal administration of 10(6) to 10(8) CFU of rBCG was well tolerated. After single or repeat rBCG inoculations, monkeys developed high-frequency gamma interferon enzyme-linked immunospot responses against BCG purified protein derivative. However, the same animals developed only modest SIV-specific CD8(+) T-cell responses. Nevertheless, high-frequency SIV-specific cellular responses were observed in the rBCG-primed monkeys after boosting with recombinant adenovirus 5 (rAd5) expressing the SIV antigens. These cellular responses were of greater magnitude and more persistent than those generated after vaccination with rAd5 alone. The vaccine-elicited cellular responses were predominantly polyfunctional CD8(+) T cells. These findings support the further exploration of mycobacteria as priming vaccine vectors.
Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action (2016)

Laspartomycin C is a lipopeptide antibiotic with activity against a range of Gram-positive bacteria including drug-resistant pathogens. We report the first total synthesis of laspartomycin C as well as a series of structural variants. Laspartomycin C was found to specifically bind undecaprenyl phosphate (C55-P) and inhibit formation of the bacterial cell wall precursor lipid II. While several clinically used antibiotics target the lipid II pathway, there are no approved drugs that act on its C55-P precursor.
Pengelolaan Lingkungan Hidup Dalam Perspektif Islam (2016)

The majority of environment damages are caused by of human actions. Those damages impact to several of natural disasters in the earth like flood, landslide, pollution etc. Actually there were various efforts which have strived to handle environment damages especially by science and technology approach, but aswer know those damages dont stop yet. Based on those facts we need new solution by other approach like approach and participation of religion to handle those problems. Because religion has force relation with the nature and environment. Besides it can convince the people that there is transcendental force of God.
Measurement of ultralow permeability (2015)

A permeability measurement method based on perturbed pressure decay between a source and a sink communicating through a porous medium is formulated. Nonideality of gas as well as corrections due to adsorption are considered. The method allows us to infer permeability at a given rock and fluid state. The accuracy of the method may be evaluated through comparison with theoretical decay characteristics and its modal amplitudes. A quantitative evaluation of the experimental inference is therefore possible. Based on the pressure decay theory, an apparatus built in our laboratory for measuring permeability is presented. As a secondary output, data analysis also provides porosity. The lowest permeability that the present apparatus is capable of characterizing is about 0.3 nm 2 , and with additional improvements, capability down to 0.05 nm 2 is anticipated. Where a steady‐state permeameter is pragmatic, excellent agreement between the two measurements is showed, validating the method. Measurements in synthetic samples also show that the method is accurate. Porosity data from a standard helium pycnometer confirm the porosity obtained from the decay method. © 2015 American Institute of Chemical Engineers AIChE J , 62: 1278–1293, 2016
Introduction of Human Telomerase Reverse Transcriptase to Normal Human Fibroblasts Enhances DNA Repair Capacity (2004)

These results indicated that hTERT/telomerase enhances DNA repair activities in NHOF. We hypothesize that hTERT/telomerase accelerates DNA repair by recruiting DNA repair proteins to the damaged DNA sites.
Why are some proteins allergenic? Implications for biotechnology (1996)

In recent years, a number of agricultural crops have been developed with recombinant DNA technology. Because the transferred genes code for proteins that are ordinarily not present in these particular foods, there is concern about the potential allergenicity of these new crop varieties. Foods contain many proteins; however, only a small fraction are allergens. Although the structural properties of proteins that cause allergic reactions have not been characterized completely, known food allergens in general have molecular weights between 10 and 70 kDa, stimulate the immune response (induce the production of allergen-specific IgE), and are stable molecules that are resistant to processing, cooking, and digestion. Although any type of food is potentially allergenic, the majority of food allergies are caused by a small group of foods (cows' milk, nuts, legumes, eggs, seafood). Cross-reactivities occur within a given food group and between foods and seemingly unrelated proteins. Even though most transgenic foods are considered safe, biotechnological manipulation can affect crop allergenicity. The safety evaluation of transgenic foods is relatively easy when the allergenicity of the gene sources are known. The recombinant food can be assayed using traditional in vitro inhibition assays. Recently, reduced allergen content of biotechnologically altered rice was shown. In contrast, increased allergenicity was demonstrated in transgenic soybeans after a methionine- and cystine-rich protein from Brazil nuts, identified as a major Brazil nut allergen, was expressed in soybean to increase its content of sulfur-rich amino acids. The most difficult issue regarding transgenic food allergenicity is the effect of transfer of proteins of unknown allergenicity. The challenge is to determine whether these proteins are allergenic as there is no generally accepted, established, definitive procedure to define or predict a protein's allergenicity. Comparing the structures of the transferred protein with known allergens and allergen epitopes could be one approach. Additionally, Th-2 cell stimulation, the production of IL-4, and IgE antibody induction in animal models may help to evaluate the potential allergenicity of a protein. In conclusion, there is no evidence that recombinant proteins in newly developed foods are more allergenic than traditional proteins. The evidence suggests that the vast majority of these proteins will be completely safe for the consumer. The concern is that if a few transgenic foods cause serious allergic reactions, this could undermine the public's confidence in such products. It is essential that proper guidelines are established and tests are developed to assure that this will not occur.
Generalized instantaneous parameters and window matching in the time-frequency plane (1997)

The concept of instantaneous parameters, which has previously been associated exclusively with 1-D measures like the instantaneous frequency and the group delay, are extended to the 2-D time-frequency plane. Such generalized instantaneous parameters are associated with the short-time Fourier transform. They may also be interpreted as local moments of certain time-frequency distributions. It is shown that these measures enable local signal behavior to be characterized in the time-frequency plane for nonstationary deterministic signals. The usefulness of the generalized instantaneous parameters is demonstrated in their application to optimal selection of windows for spectrograms. This is achieved through window matching in the time-frequency plane. An algorithm is provided that illustrates the performance of this window matching. Results based on simulated and real data are presented.