gebhart/patrepeval huggingface dataset:
Platelet expression of tumour necrosis factor-alpha (TNF-α), TNF receptors and intercellular adhesion molecule-1 (ICAM-1) in patients with proliferative diabetic retinopathy (1999)

Microvascular complications of insulin-dependent diabetes mellitus (IDDM) have been strongly associated with platelet abnormalities, whilst TNF-alpha has been implicated in the pathogenesis of this condition. However, at present it is not clear whether human circulating platelets express TNF-alpha or TNF receptors (TNF-R) or whether impaired expression of these molecules and of the TNF-reactive adhesion molecule ICAM-1 may be associated with platelet abnormalities in patients with IDDM. On this basis we investigated the platelet expression of these molecules in patients with IDDM complicated or uncomplicated by proliferative diabetic retinopathy (PDR) and in healthy subjects. We observed that the proportion of platelets staining for TNF-alpha was significantly higher in IDDM patients with active PDR than in patients without microvascular complications (P = 0.0078), quiescent PDR (P = 0.003) or healthy subjects (P = 0.0013). Patients with active PDR also showed a higher proportion of platelets expressing TNF-RI (P = 0. 0052) and TNF-RII (P = 0.015) than healthy controls or patients with quiescent PDR (P = 0.009 and 0.0006, respectively). In addition, the percentage of ICAM-1+ platelets was significantly higher in patients with active PDR than in patients with quiescent PDR (P = 0.0065) or normal subjects (P = 0.013). There was a direct correlation between platelet expression of TNF-alpha and that of TNF-R in PDR patients, indicating that platelet staining for TNF-alpha may be due to binding of this cytokine to its receptors. The results suggest that increased platelet expression of TNF-alpha, TNF-R and ICAM-1 in IDDM patients may constitute important markers of thrombocyte abnormalities during the development of microvascular complications of diabetes mellitus.
Report 33: Modelling the allocation and impact of a COVID-19 vaccine (2020)

Several SARS-CoV-2 vaccine candidates are now in late-stage trials, with efficacy and safety results expected by the end of 2020. Even under optimistic scenarios for manufacture and delivery, the doses available in 2021 are likely to be limited. Here we identify optimal vaccine allocation strategies within and between countries to maximise health (avert deaths) under constraints on dose supply. We extended an existing mathematical model of SARS-CoV-2 transmission across different country settings to model the public health impact of potential vaccines, using a range of target product profiles developed by the World Health Organization. We show that as supply increases, vaccines that reduce or block infection – and thus transmission – in addition to preventing disease have a greater impact than those that prevent disease alone, due to the indirect protection provided to high-risk groups. We further demonstrate that the health impact of vaccination will depend on the cumulative infection incidence in the population when vaccination begins, the duration of any naturally acquired immunity, the likely trajectory of the epidemic in 2021 and the level of healthcare available to effectively treat those with disease. Within a country, we find that for a limited supply (doses for <20% of the population) the optimal strategy is to target the elderly and other high-risk groups. However, if a larger supply is available, the optimal strategy switches to targeting key transmitters (i.e. the working age population and potentially children) to indirectly protect the elderly and vulnerable. Given the likely global dose supply in 2021 (2 billion doses with a two-dose vaccine), we find that a strategy in which doses are allocated to countries in proportion to their population size is close to optimal in averting deaths. Such a strategy also aligns with the ethical principles agreed in pandemic preparedness planning.
Sampling of cache congruence classes (2003)

Techniques for sampling of cache congruence classes are considered. A sampling policy that selects on the basis of where a reference hits the cache (physically) instead of when a reference arrives is examined. The notion of weighted misses is used to provide some meaningful interpretations of the miss ratios associated with workload partitioning.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Zinc-Responsive Regulon of Neisseria meningitidis Comprises 17 Genes under Control of a Zur Element (2012)

Zinc is a bivalent cation essential for bacterial growth and metabolism. The human pathogen Neisseria meningitidis expresses a homologue of the Zinc uptake regulator Zur, which has been postulated to repress the putative zinc uptake protein ZnuD. In this study, we elucidated the transcriptome of meningococci in response to zinc by microarrays and quantitative real-time PCR (qRT-PCR). We identified 15 genes that were repressed and two genes that were activated upon zinc addition. All transcription units (genes and operons) harbored a putative Zur binding motif in their promoter regions. A meningococcal Zur binding consensus motif (Zur box) was deduced in silico, which harbors a conserved central palindrome consisting of hexameric inverted repeats separated by three nucleotides (TGTTATDNHATAACA). In vitro binding of recombinant meningococcal Zur to this Zur box was shown for the first time using electrophoretic mobility shift assays. Zur binding to DNA depended specifically on the presence of zinc and was sensitive to mutations in the palindromic sequence. The Zur regulon among genes of unknown function comprised genes involved in zinc uptake, tRNA modification, and ribosomal assembly. In summary, this is the first study of the transcriptional response to zinc in meningococci.
Madefast (1996)

olitical, economic, and technological forces are changing the landscape of engineering. As the world's economies become more interconnected and more competitive, there is an increasing need for organizations to form joint design and manufacturing teams that collaborate for the life of a project and then disperse. For example, a new electromechanical product may involve a mechanical design group in Boston working closely with a control systems subcontractor in California and an OEM partner in Singapore. Similar challenges face defense contractors who need to respond rapidly to new requirements. The ARPA Manufacturing Automation and Design Engineering (MADE) program has been developing Internet-based tools, services, protocols, and design methodologies that will allow contractors to compose teams of specialists from different locations and organizations as project needs arise. As a practical test of what the MADE program has achieved, members of the MADE community undertook an ambitious exercise in Madefast: Collaborative Engineering over the Internet An exploration of collaborative capabilities when using the Web as a design tool. M a r k
Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells (2019)

GLP consumption alleviated DSS-induced colitis and may have potential for ulcerative colitis relief.
Text Adaptation for Mobile Digital Teletext (2004)

Small and varying screen sizes of mobile devices pose a big problem for digital Teletext service to display its content. It is difficult to display all the text information on a small screen, where page scroll or transparent page to live video is not practical. This paper presents an adaptive text extraction method which can automatically extract key information from original text and keep semantic meanings as close as possible. We combine both statistical methods and coarse coding algorithm from neural science to shorten long text sentences in terms of generalization. The experiment results show that the methods are efficient and effective.
Ethephon-Induced Abscission of Oil Palm Fruits at Optimal Bunch Ripeness and Retting Period to Improve Commercial Seed Production (2021)

Oil palm seed producers typically require 10 months of various processes from pollination to seed germination to produce commercial dura × pisifera hybrid seeds. Conventional forced fruit shedding from underripe fresh fruit bunches (FFB) usually causes seed damage and an extended retting period (incubation for natural fruit abscission from spikelets), eventually leading to bunch rot and disease infection. As a fruit ripening agent, ethephon has been explored to hasten fruit abscission in many fruit crops and oil palm. Nevertheless, the previous studies in oil palm only focused on fruit shedding from FFB to improve oil extraction rate in oil mills without considering the actual FFB ripeness and retting period, which are critical for oil palm seed production. In this study, the application of ethephon containing buffer (adjusted to pH 9.0) to underripe FFB at 145 days after pollination (DAP), 135 DAP and 125 DAP resulted in 50% more fruit abscission after a 72-h incubation. Considering the minimal seed loss upon FFB harvest (<1%) and 50% reduction in retting period, underripe FFB at around 145 DAP was found to be optimum for seed production using ethephon treatment. The treatment, however, made negligible improvement in fruit detachment for ripe FFB at 150 DAP and older. Importantly, seed germination and culling rate at nursery stages were not significantly affected by the ethephon treatment. Hence, ethephon application can improve commercial seed production practices for oil palm.
On-the-Fly Garbage Collection: An Exercise in Cooperation (2022)

chapter Share on On-the-Fly Garbage Collection: An Exercise in Cooperation Authors: Edsger W. Dijkstra View Profile , Leslie Lamport View Profile , A.J. Martin View Profile , C.S. Scholten View Profile , E.F.M. Steffens View Profile Authors Info & Claims Edsger Wybe Dijkstra: His Life,Work, and LegacyJuly 2022 Pages 339–358https://doi.org/10.1145/3544585.3544607Published:13 July 2022Publication History 0citation1DownloadsMetricsTotal Citations0Total Downloads1Last 12 Months1Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Zinc Sparks Are Triggered by Fertilization and Facilitate Cell Cycle Resumption in Mammalian Eggs (2011)

In last few hours of maturation, the mouse oocyte takes up over twenty billion zinc atoms and arrests after the first meiotic division, until fertilization or pharmacological intervention stimulates cell cycle progression toward a new embryo. Using chemical and physical probes, we show that fertilization of the mature, zinc-enriched egg triggers the ejection of zinc into the extracellular milieu in a series of coordinated events termed zinc sparks. These events immediately follow the well-established series of calcium oscillations within the activated egg and are evolutionarily conserved in several mammalian species, including rodents and nonhuman primates. Functionally, the zinc sparks mediate a decrease in intracellular zinc content that is necessary for continued cell cycle progression, as increasing zinc levels within the activated egg results in the reestablishment of cell cycle arrest at metaphase. The mammalian egg thus uses a zinc-dependent switch mechanism to toggle between metaphase arrest and resumption of the meiotic cell cycle at the initiation of embryonic development.
A computation method for video segmentation utilizing the pleasure-arousal-dominance emotional information (2007)

Extracting video structures is important for video indexing and navigation in large digital video archives. It is usually achieved by video segmentation algorithms. Little research efforts has been invested on segmentation solutions that utilize the video's emotional content. These solutions not only have the potential of providing better performances than existing segmentation methods, but are also able to provide a more natural video segmentation with which viewers can associate with. The development of an affect-based segmentation solution faces many challenges, such as the dynamic and time evolving nature of a video's emotional content. This paper introduces a novel computation method for affect-based video segmentation. It is designed based on the Pleasure-Arousal-Dominance (P-A-D) emotion model[18], which in principle can represent a large number of emotions. This method consists of a P-A-D estimation stage and a segmentation stage. A P-A-D estimator based on the Dynamic Bayesian Networks (DBNs) is proposed for the first stage. A clustering-based algorithm that utilizes the video's P-A-D information is proposed for the second stage. Experimental results demonstrate the feasibility of the method.
Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes <i>in vitro</i> (1998)

Chondrocytes that were isolated from adult human articular cartilage changed phenotype during monolayer tissue culture, as characterized by a fibroblastic morphology and cellular proliferation. Increased proliferation was accompanied by downregulation of the cartilage-specific extracellular matrix proteoglycan, aggrecan, by cessation of type-II collagen expression, and by upregulation of type-I collagen and versican. This phenomenon observed in monolayer was reversible after the transfer of cells to a suspension culture system. The transfer of chondrocytes to suspension culture in alginate beads resulted in the rapid upregulation of aggrecan and type-II collagen and the downregulation of expression of versican and type-I collagen. Type-X collagen and osteopontin, markers of chondrocyte hypertrophy and commitment to endochondral ossification, were not expressed by adult articular chondrocytes cultured in alginate, even after 5 months. In contrast, type-X collagen was expressed within 2 weeks in a population of cells derived from a fetal growth plate. The inability of adult articular chondrocytes to express markers of chondrocyte hypertrophy has underscored the fundamental distinction between the differentiation pathways that lead to articular cartilage or to bone. Adult articular chondrocytes expressed only hyaline articular cartilage markers without evidence of hypertrophy.
<sup>99m</sup>Tc-CN7DG: A Highly Expected SPECT Imaging Agent of Cancer with Satisfactory Tumor Uptake and Tumor-to-Nontarget Ratios (2021)

A novel glucose derivative (CN7DG) possessing an isonitrile as a coordinating group was synthesized, and <sup>99m</sup>Tc-CN7DG, which was expected to be a powerful tumor imaging agent for SPECT, was prepared in a kit by the reaction of CN7DG with SnCl<sub>2</sub>·2H<sub>2</sub>O and <sup>99m</sup>TcO<sub>4</sub><sup>-</sup>. <sup>99m</sup>Tc-CN7DG exhibited good stability and was transported via glucose transporters. Biodistribution results in mice bearing A549 tumor models showed that <sup>99m</sup>Tc-CN7DG had a higher uptake at the tumor sites and better tumor/blood and tumor/muscle ratios than did [<sup>18</sup>F]FDG and <sup>99m</sup>Tc-CN5DG. SPECT/CT imaging studies showed obvious accumulation in tumor sites, suggesting that <sup>99m</sup>Tc-CN7DG is a promising candidate for tumor imaging. Because <sup>99m</sup>Tc and <sup>188</sup>Re stand for a "theranostic pair", <sup>188</sup>Re-CN7DG is expected to be prepared as a promising agent for tumor therapy.
In vivo processing of N‐terminal methionine in <i>E. coli</i> (1990)

The processing of amino-terminal methionine from cytosolic proteins in E. coli has been investigated in vivo, using amino-terminal-extended human growth hormone (hGH) as a model system. Twenty different hGH-genes with the sequence Met-Xxx-Glu-Glu-hGH where Xxx denotes each of the 20 different amino acids, were constructed and expressed in E. coli. Following purification of the products, the N-terminal amino acid sequences (10 cycles) were determined. The results demonstrate that the removal of methionine is dependent on the amino acid adjacent to methionine, and that the processing is strongly correlated to the radius of gyration of this amino acid. In addition, measurement of the hGH expression level from the 20 clones demonstrated that the small difference in the amino acid extension leads to a change in the specific hGH expression rate.
The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF<sub>II</sub>30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex (2000)

We have purified and characterized a Gcn5-independent nucleosomal histone H3 HAT complex, NuA3 (Nucleosomal Acetyltransferase of histone H3). Peptide sequencing of proteins from the purified NuA3 complex identified Sas3 as the catalytic HAT subunit of the complex. Sas3 is the yeast homolog of the human MOZ oncogene. Sas3 is required for both the HAT activity and the integrity of the NuA3 complex. In addition, NuA3 contains the TBP- associated factor, yTAF(II)30, which is also a component of the TFIID, TFIIF, and SWI/SNF complexes. Sas3 mediates interaction of the NuA3 complex with Spt16 both in vivo and in vitro. Spt16 functions as a component of the yeast CP (Cdc68/Pob3) and mammalian FACT (facilitates chromatin transcription) complexes, which are involved in transcription elongation and DNA replication. This interaction suggests that the NuA3 complex might function in concert with FACT-CP to stimulate transcription or replication elongation through nucleosomes by providing a coupled acetyltransferase activity.
Thermoresponsive, spin-labeled hydrogels as separable DNP polarizing agents (2010)

In this work, we present thermoresponsive, spin-labeled hydrogels that bear great potential for applications in dynamic nuclear polarization (DNP). In our approach, the water and other polarized molecules are efficiently separated from the radicals needed for DNP by a thermally induced collapse of a polymer network resulting in a prolonged lifetime of the hyperpolarization.
[The use of monoclonal antibodies for the quantitative determination of myoglobin by the solid phase immunoenzyme "sandwich" assay]. (1989)

A procedure of solid phase single step immunoenzyme assay of the "sandwich" type involving monoclonal antibodies was developed to estimate myoglobin in blood serum of patients, 30 stable hybridomic clones. producing antibodies to not less than six various epitopes of myoglobin, were obtained. Content of myoglobin in blood serum was studied using antibodies of the IgG type to two various epitopes of myoglobin as well as of their conjugates with horseradish peroxidase. The procedure developed enabled to estimate myoglobin in blood serum at concentrations 2-1,600 ng/ml and to analyze 120 preparations within 3 hrs.
Observations of Macroporous Gallium Nitride Electrochemically Etched from High Doped Single Crystal Wafers in HF Based Electrolytes (2013)

International audience
Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid arthritis (2015)

This study demonstrates that the activation of DKK-1 and the integrin-related FAK signalling pathway stimulated by TNF-α induces the dissociation of β-catenin/E-cadherin, thus promoting RA FLS migration.
Biomarkers for acute kidney injury in decompensated cirrhosis: A prospective study (2018)

In patients with decompensated cirrhosis, early measurement of renal biomarkers provides valuable information on AKI aetiology. It could also improve AKI diagnosis and prognosis.
Survey on Various Gesture Recognition Technologies and Techniques (2012)

Gestures considered as the most natural expressive way for communications between human and computers in virtual system. Hand gesture is a method of non-verbal communication for human beings for its freer expressions much more other than body parts. Hand gesture recognition has greater importance in designing an efficient human computer interaction system. Using gestures as a natural interface benefits as a motivation for analyzing, modeling, simulation, and recognition of gestures. In this paper a survey on various recent gesture recognition approaches is provided with particular emphasis on hand gestures. A review of static hand posture methods are explained with different tools and algorithms applied on gesture recognition system, including connectionist models, hidden Markov model, and fuzzy clustering. Challenges and future research directions are also highlighted.
Abstract 2343: A novel ERK inhibitor is active in models of acquired resistance to BRAF and MEK inhibitors. (2013)

Abstract The high frequency of activating BRAFV600E mutations in melanoma (40-70%), thyroid (50%) and colorectal cancer (10%), or KRAS/NRAS mutations in melanoma (20%), pancreatic (90%), colorectal (50%) and non-small cell lung cancer (30%), provides strong rationale for targeting the MAPK pathway as a therapeutic strategy 1-6. Vemurafenib (PLX4032) and dabrafenib (GSK2118436), selective BRAF inhibitors, and trametinib (GSK1120212), an allosteric MEK inhibitor, have shown robust clinical efficacy in melanoma patients 7-10. However, the majority of responses are transient and cellular resistance is often associated with pathway reactivation involving the downstream extracellular-signal-regulated kinases 1 and 2 (ERK1/2) (reviewed in 11). We hypothesized that pathway blockade at ERK, the last signaling node prior to MAPK transcriptional programming, would not only be efficacious in MAPK-activated tumors but would also have utility in BRAF or MEK inhibitor resistant settings. We therefore sought to identify small molecule inhibitors of ERK. This report describes the identification and characterization of SCH772984, a potent and selective ATP competitive inhibitor of ERK1/2 which displays behaviors of both type I and type II kinase inhibitors. SCH772984 has nanomolar cellular potency on tumor cells with mutations in BRAF, NRAS, or KRAS and induces tumor regressions in xenograft models at tolerated doses. Importantly, SCH772984 effectively inhibited MAPK signaling and cell proliferation in BRAF or MEK inhibitor resistant models as well as in the context of BRAF/MEK combination resistance. Together these data support the clinical development of ERK inhibitors, not only in patients with MAPK activated tumors, but also in patients who have developed acquired resistance to BRAF or MEK inhibitors or resistance to the recently described combination of these agents. Citation Format: Ahmed A. Samatar, Erick J. Morris, Sharda Jha, Restaino R. Clifford, Bart Luttrerbach, Marc Pelletier, Ulrike Philippar, Lata Jayaraman, Leigh Zawel, Steve Fawell, Gary Gilliland. A novel ERK inhibitor is active in models of acquired resistance to BRAF and MEK inhibitors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2343. doi:10.1158/1538-7445.AM2013-2343
A Trolling Hierarchy in Social Media and A Conditional Random Field For Trolling Detection (2017)

An-ever increasing number of social media websites, electronic newspapers and Internet forums allow visitors to leave comments for others to read and interact. This exchange is not free from participants with malicious intentions, which do not contribute with the written conversation. Among different communities users adopt strategies to handle such users. In this paper we present a comprehensive categorization of the trolling phenomena resource, inspired by politeness research and propose a model that jointly predicts four crucial aspects of trolling: intention, interpretation, intention disclosure and response strategy. Finally, we present a new annotated dataset containing excerpts of conversations involving trolls and the interactions with other users that we hope will be a useful resource for the research community.