gebhart/patrepeval huggingface dataset:
A 1 V operating 256-Kbit full CMOS SRAM (1990)

A full CMOS six-transistor memory cell was fabricated with single-polysilicon, double-metal technology. The channel lengths of n-channel and p-channel transistors are 0.8 μm and 1.2 μm and the cell sizes are 8.5 μm×12.8 μm, respectively. The gate oxide thickness is 200 Å, and the lightly doped drain (LDD) structure is adopted for the n-channel transistor. A 256-kb full CMOS SRAM utilizing the new technology has achieved a wide operating voltage from 1 V to 7 V and 5 mW (at <e1 xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</e1> =1 MHz & <e1 xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</e1> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> =5 V) and 0.2 mW (at <e1 xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</e1> =1 MHz & VCC=1 V) power dissipation. The address input and data output signals with 100 pF load capacitance of <e1 xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</e1> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CC</sub> =1 V are shown
Historical Perspectives on Clinical Cardiac Electrophysiology (2002)

Cardiac electrophysiology is an extremely new and dynamic discipline. Although its roots may be traced to the beginning of the twentieth century, clinical cardiac electrophysiology proper was born in the late 1960s. During this short time period, cardiac electrophysiology has undergone several major paradigm shifts. At the onset, clinical electrophysiologists strove to understand the physiology of the conducting system and cardiac arrhythmias. This initial phase of exploration evolved into a diagnostic field, in which electrophysiologic studies could be used to assess risk and to define the arrhythmia diagnosis, although therapeutic interventions were relatively modest. The past decade has witnessed a virtual explosion in interventional electrophysiology, with an increasing reliance on nonpharmacologic therapies. Throughout this period, cellular electrophysiologists, animal researchers, and more recently, molecular geneticists, have worked to advance our understanding of the mechanisms of arrhythmias at a more basic level than previously appreciated.
Identification of candidate anti-cancer molecular mechanisms of Compound Kushen Injection using functional genomics (2016)

Compound Kushen Injection (CKI) has been clinically used in China for over 15 years to treat various types of solid tumours. However, because such Traditional Chinese Medicine (TCM) preparations are complex mixtures of plant secondary metabolites, it is essential to explore their underlying molecular mechanisms in a systematic fashion. We have used the MCF-7 human breast cancer cell line as an initial in vitro model to identify CKI induced changes in gene expression. Cells were treated with CKI for 24 and 48 hours at two concentrations (1 and 2 mg/mL total alkaloids), and the effect of CKI on cell proliferation and apoptosis were measured using XTT and Annexin V/Propidium Iodide staining assays respectively. Transcriptome data of cells treated with CKI or 5-Fluorouracil (5-FU) for 24 and 48 hours were subsequently acquired using high-throughput Illumina RNA-seq technology. In this report we show that CKI inhibited MCF-7 cell proliferation and induced apoptosis in a dose-dependent fashion. We integrated and applied a series of transcriptome analysis methods, including gene differential expression analysis, pathway over-representation analysis, de novo identification of long non-coding RNAs (lncRNA) as well as co-expression network reconstruction, to identify candidate anti-cancer molecular mechanisms of CKI. Multiple pathways were perturbed and the cell cycle was identified as the potential primary target pathway of CKI in MCF-7 cells. CKI may also induce apoptosis in MCF-7 cells via a p53 independent mechanism. In addition, we identified novel lncRNAs and showed that many of them might be expressed as a response to CKI treatment.
Endogenous Population Dynamics and Economic Growth with Free Trade between Countries (2016)

This paper builds a model to deal with dynamic interdependence between different countries' birth rates, mortality rates, populations, wealth accumulation, and time distributions between working, leisure and children caring. The model shows the role of human capital, technological and preference changes on national differences in birth rates, mortality rates, time distributions, population change, and wealth accumulation. The economic mechanisms of wealth accumulation, production and trade are based the Solow growth model and the Oniki-Uzawa trade model. We use the utility function proposed by Zhang to describe the behavior of households. We model national and gender differences in human capital, propensity to have children, propensity to use leisure time, and children caring efficiency. We describe the dynamics of global economic growth, trade patterns, national differences in wealth, income, birth rates, mortality rates, and populations with differential equations. We simulate the model to show the motion of the system and identify the existence of equilibrium point. We also examine the effects of changes in the propensity to have children, the propensity to save, woman's propensity to use leisure, woman's human capital, and woman's emotional involvement in children caring on the dynamics of the global and national economies.
A computer with low-level parallelism QA-2: its applications to 3-D graphics and Prolog/Lisp machines (1986)

We proposed a computer with low-level parallelism as one of the basic computer architectures and built a large scale experimental system called QA-2. By low-level parallelism, we mean that a long-word instruction controls simultaneously many ALUs, busses, registers and memories in a mode of fine-grained parallelism. The QA-2 employs a 256-bit instruction by which four different ALU operations, four memory accesses to different/continuous locations and one powerful sequence control are all specified and performed in parallel. If many simultaneously executable operations are detected and embedded in one instruction at compile time, this type of computer can provide a high-degree of performance for a wide variety of applications. This paper describes the architectural benefits and limitations of low-level parallelism in performing 3-D color image generation and interpreting Prolog/Lisp programs. The hardware organization with four ALUs, which are actually implemented in the QA-2, is verified to be adequate. In fact, nearly three out of four ALUs can work in parallel. Any architecture with more than four ALUs can not achieve a significant degree of performance enhancement. This paper also shows the degree of performance improvement achieved by the techniques such as ALU chaining and highly-structured sequence control mechanisms. As compared with the IBM 370 architecture, the QA-2 can generate 3-D color images in 1/5 of dynamic instruction steps. The compiler version of Prolog machine on the QA-2 is as fast (45K LIPS) as the ICOT's PSI. From all results, we expect that the QA-2 is a high-performance computer which will be utilized in the future personal computing environment.
Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences. (1983)

An eel calmodulin cDNA probe has been used to isolate a calmodulin gene from a chicken DNA library. Sequence analysis revealed this calmodulin gene (cCM1) to contain the nucleotides that code for 148 amino acids, a termination codon, and 486 residues of 3'-noncoding sequence before an A-A-T-A-A-A poly(A) addition signal. The amino acid sequence derived from these nucleotides is 87% homologous to that of bovine brain calmodulin. cCM1 is one of two calmodulin genes in the chicken genome but is unique in that it does not contain intervening sequences to interrupt the structural segments of the protein. This suggests that cCM1 originated as a processed gene copy derived from the other calmodulin gene, cCL1, a circumstance usually associated with pseudogenes. In contrast, cCM1 appears to be a functional member of a multigene family whose expression is specific for muscle cells.
A frequency enhanced single package multi-die memory system using an in-package flyby configuration (2014)

We presented an advanced, highly integrated multi-die memory module design of flyby connections, using face-down wire bond assembly technology for DDRx and LPDDR3 operations up to 2400 MT/s. Focusing on LPDDR3 memory, we analyzed the performance impact in different C/A bus topologies and package layouts.
A GaAs Nanowire Array Solar Cell With 15.3% Efficiency at 1 Sun (2015)

A GaAs nanowire array solar cell with an independently verified solar energy conversion efficiency of 15.3% and open-circuit voltage of 0.906 V under AM1.5g solar illumination at 1-sun intensity has been fabricated. This is the highest published efficiency for nanowire array solar cells and is twice the prior record for GaAs nanowire array solar cells. The solar cell has been fabricated by substrate-based epitaxy but is structurally compatible with substrate-less aerotaxy fabrication, providing a path to high-volume manufacturing. The short-circuit current of 21.3 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> was generated with axial p-n junction GaAs cores covering 13% of the surface area, which is a volume of GaAs equivalent to a 370-nm-thick planar layer.
Low-Loss, High-Linearity RF Interposers Enabled by Through Glass Vias (2018)

This letter reports on a new low-loss and high-linearity 3-D wafer-level interposer technology enabled by through glass vias (TGVs) with an inverted via configuration. The proposed TGV utilizes a tapered via sidewall profile to achieve a void-free conformal metal coverage with lower process time and fewer fabrication steps than a fully filled conventional TGV. Measurement results for a single 100-μm-tall TGV show an insertion loss of 0.014 dB at 10 GHz and a dc resistance of 28 mQ. Finally, this letter reports, for the first time, on nonlinearity measurements of TGVs. Single-tone measurements show that the third-harmonic level for a coplanar waveguide (CPW) TGV test structure is only 2 dB higher than a reference CPW through line without TGVs, indicating an overall excellent linearity performance.
CLICK-UP (2018)

short-paper Free Access Share on CLICK-UP: Towards Software Upgrades of Click-driven Stateful Network Elements Authors: Junxiao Wang Dalian University of Technology, Queen Mary University of London Dalian University of Technology, Queen Mary University of LondonView Profile , Yuchen Huang Dalian University of Technology, Queen Mary University of London Dalian University of Technology, Queen Mary University of LondonView Profile , Heng Qi Dalian University of Technology, Queen Mary University of London Dalian University of Technology, Queen Mary University of LondonView Profile , Keqiu Li Dalian University of Technology, Queen Mary University of London Dalian University of Technology, Queen Mary University of LondonView Profile , Steve Uhlig Dalian University of Technology, Queen Mary University of London Dalian University of Technology, Queen Mary University of LondonView Profile Authors Info & Claims SIGCOMM '18: Proceedings of the ACM SIGCOMM 2018 Conference on Posters and DemosAugust 2018 Pages 117–119https://doi.org/10.1145/3234200.3234206Published:07 August 2018Publication History 1citation443DownloadsMetricsTotal Citations1Total Downloads443Last 12 Months116Last 6 weeks17 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Research conference summary from the 2014 International Task Force on <i>ATP1A3</i> -Related Disorders (2017)

This report summarizes recommendations of the workshop committee, highlighting the key phenotypic features to facilitate the diagnosis of possible <i>ATP1A3</i> mutations, providing recommendations for genetic testing, and outlining initial acute management for common recurrent clinical conditions, including epilepsy.
Data communication in hypercubes (1989)

In this paper we consider several algorithms for exchanging data among processors in a hypercube network. The data transfer problems considered are those arising from classical numerical algorithms such as Gaussian elimination, conjugate gradient methods, and the N-body problem. We propose some estimates for the timings of the various algorithms which reveal that multiprocessors based on the hypercube topology can be very efficient in performing data exchange operations.
Activation of C−H / H−H Bonds by Rhodium(II) Porphyrin Bimetalloradicals (2004)

Reactivity, kinetic, and thermodynamic studies are reported for reactions of a rhodium(II) bimetalloradical with H(2), and with the methyl C-H bonds for a series of substrates CH(3)R (R = H, CH(3), OH, C(6)H(5)) using a m-xylyl diether tethered diporphyrin ligand. Bimolecular substrate reactions involving the intramolecular use of two metalloradical centers and preorganization of the four-centered transition state (M*...X...Y*...M) result in large rate enhancements as compared to termolecular reactions of monometalloradicals. Activation parameters and deuterium kinetic isotope effects for the substrate reactions are reported. The C-H bond reactions become less thermodynamically favorable as the substrate steric requirements increase, and the activation free energy (DeltaG++) decreases regularly as DeltaG degrees becomes more favorable. An absolute Rh-H bond dissociation enthalpy of 61.1 +/- 0.4 kcal mol(-1) is directly determined, and the derived Rh-CH(2)R BDE values increase regularly with the increase in the C-H BDE.
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle (2019)

Abstract The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 strains in animal models. However, NAb responses are relatively weak and narrow in specificity. Displaying antigens in a multivalent fashion on nanoparticles (NPs) is an established strategy to increase their immunogenicity. Here we present the design and characterization of two-component protein NPs displaying 20 stabilized SOSIP trimers from various HIV-1 strains. The two-component nature permits the incorporation of exclusively well-folded, native-like Env trimers into NPs that self-assemble in vitro with high efficiency. Immunization studies show that the NPs are particularly efficacious as priming immunogens, improve the quality of the Ab response over a conventional one-component nanoparticle system, and are most effective when SOSIP trimers with an apex-proximate neutralizing epitope are displayed. Their ability to enhance and shape the immunogenicity of SOSIP trimers make these NPs a promising immunogen platform.
Basic and applied aspects of metabolic diversity: The phosphoenolpyruvate node (1996)

The phosphoenolpyruvate (PEP) node represents a metabolic crossroad where carbon is distributed into several metabolic pathways. This node is specially important for the industrial production of several metabolites. Depending on the organism and its habitat, the enzymes that utilize PEP are regulated by different effectors, and each branch of the node is important in PEP consumption. In this review we will focus our attention on the metabolic diversity of this node.
The cultural construction of self and emotion: Implications for well-being (2010)

Let a man lift himself by his own self alone; let him not degrade himself
because the self alone is the friend of oneself and the self is the enemy of
oneself. For one who has conquered his very self by his own self, his very self
becomes his friend, but for one who has not conquered his self, his very
self will act inimically, as would an actual enemy.
Immunological reactivity of antisera to sodium dodecyl sulfate-derived polypeptides of polyoma virions (1977)

A study was undertaken to produce antisera to sodium dodecyl sulfate-derived polyoma virion polypeptides. With the use of this antisera, it was possible to detect, by immunofluorescence, cytoplasmic synthesis of V1, V2, and V3 polypeptides at 18 h postinfection and subsequent transport to the nucleus by 22 h postinfection. Anti-V1, anti-V2, and anti-V3 sera did not react with intact virions in an immunodiffusion assay, nor did they possess hemagglutination inhibition or viral neutralization activity. Antiserum produced against the four host histone polypeptides (V4 through V7) demonstrated immunofluorescence when reacted with polyoma-infected cells but not with uninfected cells. Antihistone serum was also capable of neutralizing viral infectivity, inhibiting hemagglutination and reacting with whole virions in an immunodiffusion assay.
Radioiodinated Portable Albumin Binder as a Versatile Agent for <i>in Vivo</i> Imaging with Single-Photon Emission Computed Tomography (2019)

In this study, radioiodinated 4-( p-iodophenyl)butyric acid ([<sup>131</sup>I]IBA) was synthesized and evaluated as a portable albumin-binder for potential applications in single photon emission computed tomography imaging of blood pool, tumor, and lymph node with significantly improved pharmacokinetic properties. The [<sup>131</sup>I]IBA was prepared under the catalyst of Cu<sub>2</sub>O/1,10-phenanthroline. After that, the albumin-binding capability of [<sup>131</sup>I]IBA was tested in vitro, ex vivo, and in vivo, respectively. [<sup>131</sup>I]IBA was obtained with very high radiolabeling yield (>99%) and good radiochemical purity (>98%) within 10 min. It binds to albumin effectively with high affinity (IC<sub>50</sub>= 46.5 μM) and has good stability. The results of biodistribution indicated that the [<sup>131</sup>I]IBA was mainly accumulated in blood with good retention (10.51 ± 2.58%ID/g at 30 min p.i. and 4.63 ± 0.17%ID/g at 4 h p.i.). In the SPECT imaging of mice models with [<sup>131</sup>I]IBA, blood pool, lymph node, and tumors could be imaged clearly with high target-to-background ratio. Overall, the radioiodinated albumin binder of [<sup>131</sup>I]IBA with long blood half-life and excellent stability could be used to decorate diversified albumin-binding radioligands and developed as a versatile theranostic agent.
Phase 1 first-in-human trial of the anti-CD37 antibody BI 836826 in relapsed/refractory chronic lymphocytic leukemia (2019)

To the Editor: Chronic lymphocytic leukemia (CLL) remains incurable for most patients, requiring repeated therapy [1]. The tetraspanin CD37 is predominantly expressed on mature B cells, with low-level expression on T cells, granulocytes, and monocytes, and is widely expressed in mature B-cell malignancies, including CLL [...]
Print-and-scan counterattacks for plastic card supports Fourier watermarking (2014)

In recent past years, Fourier based watermarking techniques have been developed to deal with the print-and-scan attack. In this work, print-and-scan counterattacks for Fourier watermarking are proposed in the context of an industrial application where identity (ID) images are printed and scanned on a plastic card support. The counterattacks are within two stages. The first stage concerns the reduction of image blurring that occurs during the print-and-scan process. Blind restoration and unsharp filters already proposed elsewhere are compared to a Wiener filter adapted to the print-and-scan channel. The second stage deals with the color corrections. These image counterattacks are applied before the watermark retrieval. The proposed method has been experimentally tested on a set of 100 ID images. Results show that the adapted Wiener filter outperforms the blind restoration and unsharp filters in terms of detection rate and distance between empirical probability density functions of correlation values from marked and unmarked images. Finally, the color correction allows a noticeable increase of the overall performances of the method.
Calculation of attenuations and phase shifts due to melting layer (1991)

The specific attenuation and specific phase shift in the melting layer, the average specific attenuation and average specific phase shift of the melting layer, and the related zenith excess of attenuation, phase shift, differential attenuation and differential phase shift are calculated over a frequency range of 1-100 GHz for rain rates below 12.5 mm/h. The numerical results have been computed for oblate spheroidal melting particles and five drop size distributions. These new results can be used in the design of earth-space communications systems.
Nanodiamonds for biological investigations (2004)

Nanoparticles with a modified surface are prepared from nanodiamonds produced in Russia. The properties of modified nanodiamonds and their hydrosols and organosols are investigated by biophysicists with the aim of preparing nanoparticles with controlled properties for solving biological problems.
Immunocytochemical localization of the dopamine transporter in human brain (1999)

The dopamine transporter (DAT) was localized in normal human brain tissue by light microscopic immunocytochemistry by using highly specific monoclonal antibodies. Regional distribution of DAT was found in areas with established dopaminergic circuitry, e.g., mesostriatal, mesolimbic, and mesocortical pathways. Mesencephalic DAT-immunoreactivity was enriched in the dendrites and cell bodies of neurons in the substantia nigra pars compacta and ventral tegmental area. Staining in the striatum and nucleus accumbens was dense and heterogeneous. Mesocortical DAT immunoreactivity in motor, premotor, anterior cingulate, prefrontal, entorhinal/perirhinal, insular, and visual cortices was detected in scattered varicose and a few nonvaricose fibers. Varicose fibers were relatively enriched in the basolateral and central subnuclei of amygdala, with sparser fibers in lateral and basomedial subnuclei. Double-labeling studies combining DAT and tyrosine hydroxylase (TH) immunostaining in the ventral mesencephalon showed two subpopulations of dopaminergic neurons differentiated by the presence or absence of DAT-immunoreactivity in the A9 and A10 cell groups. In other dopaminergic cell groups (All, A13-A15), TH-positive hypothalamic neurons showed no detectable DAT-immunoreactivity. However, fine DAT-immunoreactive axons were scattered throughout the hypothalamus, particularly concentrated along the medial border, with more coarse axons present along the lateral border. These findings demonstrate that most mesotelencephalic dopamine neurons of human brain express high levels of DAT throughout their entire somatodendritic and axonal domains, whereas a smaller subpopulation of mesencephalic dopamine cells and all hypothalamic dopamine cell groups examined express little or no DAT. These data indicate that different subpopulations of dopaminergic neurons use different mechanisms to regulate their extracellular dopamine levels.