gebhart/patrepeval huggingface dataset:
Recognition of Misfolding Proteins by PA700, the Regulatory Subcomplex of the 26 S Proteasome (2000)

The 26 S proteasome is a large protease complex that catalyzes the degradation of both native and misfolded proteins. These proteins are known to interact with PA700, the regulatory subcomplex of the 26 S proteasome, via a covalently attached polyubiquitin chain. Here we provide evidence for an additional ubiquitin-independent mode of substrate recognition by PA700. PA700 prevents the aggregation of three incompletely folded, nonubiquitinated substrates: the DeltaF-508 mutant form of cystic fibrosis transmembrane regulator, nucleotide binding domain 1, insulin B chain, and citrate synthase. This function does not require ATP hydrolysis. The stoichiometry required for this function, the effect of PA700 on the lag phase of aggregation, and the temporal specificity of PA700 in this process all indicate that PA700 interacts with a subpopulation of non-native conformations that is either particularly aggregation-prone or nucleates misassociation reactions. The inhibition of off-pathway self-association reactions is also reflected in the ability of PA700 to promote refolding of citrate synthase. These results provide evidence that, in addition to binding polyubiquitin chains, PA700 contains a site(s) that recognizes and interacts with misfolded or partially denatured polypeptides. This feature supplies an additional level of substrate specificity to the 26 S proteasome and a means by which substrates are maintained in a soluble state until refolding or degradation is complete.
Rhizome: A Feature Modeling and Generation Platform (2008)

Rhizome is an end-to-end feature modeling and code generation platform that includes a feature modeling language (FeatureML), a template language (MarkerML) and a template-based code generator. A software designer creates feature models using FeatureML by selecting and defining design choices. These design choices can be automatically associated with code templates and interpreted as parameter values for code generation. The code generator then replaces markers embedded in the code templates with dynamically generated code blocks to produce source code.
An association between psoriasis and hereditary multiple exostoses. A clue for the mapping of a psoriasis susceptibility gene? (1994)

Chronic plaque psoriasis affects approximately 1.6% of the U.K. population. Population, family and twin studies all strongly suggest an important genetic component in the pathogenesis of the disease, although genetic linkage studies have, so far, failed to identify susceptibility genes. We describe a family in which psoriasis cosegregates through three generations with a known autosomal dominant disorder, hereditary multiple exostoses (HME). A major locus for HME has recently been mapped to chromosome 8q. Observations in this family may provide a mapping clue for a psoriasis susceptibility gene.
A Step Closer to Extreme Drug Resistance (XDR) in Gram-Negative Bacilli (2007)

45-9-1179
Chromatofocusing (2001)

Abstract Chromatofocusing is a form of gradient elution chromatography performed using an ion‐exchange column packing and an internally generated pH gradient that travels through the column as a retained pH front.
Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1 (1997)

In the absence of costimulation, T cells activated through their antigen receptor become unresponsive (anergic) and do not transcribe the gene encoding interleukin-2 (IL-2) when restimulated with antigen. Anergic alloantigen-specific human T cells contained phosphorylated Cbl that coimmunoprecipitated with Fyn. The adapter protein CrkL was associated with both phosphorylated Cbl and the guanidine nucleotide-releasing factor C3G, which catalyzes guanosine triphosphate (GTP) exchange on Rap1. Active Rap1 (GTP-bound form) was present in anergic cells. Forced expression of low amounts of Rap1-GTP in Jurkat T cells recapitulated the anergic defect and blocked T cell antigen receptor (TCR)- and CD28-mediated IL-2 gene transcription. Therefore, Rap1 functions as a negative regulator of TCR-mediated IL-2 gene transcription and may be responsible for the specific defect in IL-2 production in T cell anergy.
User Profiling Through Browser Finger Printing (2016)

The modern world is changing rapidly. Now a day the use of internet is categorized as essentials for a common man. Everything is put on the web as it is bringing ease of access to the user. The web usage is doubled by the paradigm shift i.e. the smart phones. Online shopping has become a basic and ease of access unit of the user. Because of the huge traffic on the websites the marketing and the advertisement companies have a huge task of displaying relevant advertisements or products to users. To do this they need to track online habits of users and creating their fingerprints or a persona of the respective user. This research has different examinations on user and web-based fingerprinting. The main concept of browser fingerprinting is to gather the data even if the cookies are cleared or disabled by the user. In this paper, we examine how to track user on the basis of his/her system's profile. In this research we have extracted different hacks and exploit the browser. We have discussed that how the browser can be exploited to identify the user. The application of this work is in sales, marketing and promotions etc.
p-Nitrophenyl carbamates as active-site-specific reagents for serine proteases (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTp-Nitrophenyl carbamates as active-site-specific reagents for serine proteasesRolfe E. Scofield, Robert P. Werner, and Finn WoldCite this: Biochemistry 1977, 16, 11, 2492–2496Publication Date (Print):May 31, 1977Publication History Published online1 May 2002Published inissue 31 May 1977https://pubs.acs.org/doi/10.1021/bi00630a027https://doi.org/10.1021/bi00630a027research-articleACS PublicationsRequest reuse permissionsArticle Views266Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
WORD OUTLOOK (1990)

As the world economy enters the 1990% a significant reorientation of growth and demand is taking place amongst the major economies. The desynchronuation of the economic cycle, which occurred last year as the US economy slowed down while Europe and Japan continued to advance rapidly, is likely to be taken a stage further. Europe, in particular West Germany, is expected to continue to grow quickly in the run‐up to the completion of the single EC market in 1992 and as a result of the opening of eastern Europe. Japan and the Asian NICs, adapting with an unprecedented programmed of industrial re‐tooling to their new circumstances, are already set on an accelerated growth path. In contrast, the US appears to be in for a period of sluggish growth, as the Fed attempts to press down on inflation without causing a recession. As a result we expect US output growth of only 2 per cent a year over the next few years compared with a sustainable 3 per cent in Germany and 4 per cent in Japan. Despite these differences in growth, US inflation performance lags behind that in Germany and Japan and, partly because of the sue of existing IPD flows, little progress is like& on reducing current account imbalances.
Intracity Quantum Communication via Thermal Microwave Networks (2017)

Communication over proven-secure quantum channels is potentially one of the most wide-ranging applications of currently developed quantum technologies. It is generally envisioned that in future quantum networks, separated nodes containing stationary solid-state or atomic qubits are connected via the exchange of optical photons over large distances. In this work, we explore an intriguing alternative for quantum communication via all-microwave networks. To make this possible, we describe a general protocol for sending quantum states through thermal channels, even when the number of thermal photons in the channel is much larger than 1. The protocol can be implemented with state-of-the-art superconducting circuits and enables the transfer of quantum states over distances of about 100 m via microwave transmission lines cooled to only T 4 K. This opens up new possibilities for quantum communication within and across buildings and, consequently, for the implementation of intracity quantum networks based on microwave technology only.
SmartChat – An Intelligent Environment for Collaborative Discussions (2023)

Collaborative learning can be motivated via environments that provide<br> communication, and areas for discussion. In such environments, both students and<br> instructors need online support in order to produce useful interactions. In this paper we<br> present SmartChat, an intelligent environment for collaborative discussions. It uses an<br> argumentation model to organise users interactions and it classifies users in pre-defined<br> stereotypes, based on their participation in the discussion. That classification helps the<br> SmartChat's agent society to interfere in the discussion, in order to motivate users<br> participation, and also recommend references or incentivate pair collaboration. SmartChat<br> was developed in Java, using a knowledge base accessed through JEOPS. The initial tests<br> have indicated promising results.
Retraining and assessing hand movement after stroke using the MusicGlove: comparison with conventional hand therapy and isometric grip training (2014)

These results support the hypothesis that hand therapy that is engaging, incorporates high numbers of repetitions of gripping and thumb-finger opposition movements, and promotes afferent input is a promising approach to improving an individual's ability to manipulate small objects. The MusicGlove provides a simple way to access such therapy.
<i>N</i>-Allyl-<i>N</i>,<i>N</i>-Bis(trimethylsilyl)amine as a Novel Electrolyte Additive To Enhance the Interfacial Stability of a Ni-Rich Electrode for Lithium-Ion Batteries (2018)

Enhancing the electrode/electrolyte interface stability of high-capacity LiNi<sub>0.8</sub>Co<sub>0.15</sub>Al<sub>0.05</sub>O<sub>2</sub> (LNCA) cathode material is urgently required for its application in next-generation lithium-ion battery. Herein, we demonstrate that enhanced interfacial stability of LNCA can be achieved by simply introducing 2 wt % N-allyl- N, N-bis(trimethylsilyl)amine (NNB) electrolyte additive. Electrolyte oxidation reactions and electrode structural destruction are greatly suppressed in the electrolyte with NNB additive, leading to improved cyclic stability of LNCA from 72.8 to 86.2% after 300 cycles. The mechanism of NNB on improving the cyclic stability of LNCA has been verified to its excellent solid electrolyte interface (SEI) film-forming capability. Moreover, the X-ray diffraction and X-ray photoelectron spectroscopy results indicate that the NNB-derived Si-containing SEI film restrains the Li/Ni disorder of LNCA during cycling, which further improves the cyclic stability of Ni-rich LNCA. Importantly, the charging/discharging test reveals that the NNB additive effectively improves the cyclic stability of the LNCA/graphite full cell.
Exeum: A Decentralized Financial Platform for Price-Stable Cryptocurrencies (2018)

Price stability has often been cited as a key reason that cryptocurrencies have not gained widespread adoption as a medium of exchange and continue to prove incapable of powering the economy of decentralized applications (DApps) efficiently. Exeum proposes a novel method to provide price stable digital tokens whose values are pegged to real world assets, serving as a bridge between the real world and the decentralized economy. Pegged tokens issued by Exeum - for example, USDE refers to a stable token issued by the system whose value is pegged to USD - are backed by virtual assets in a virtual asset exchange where users can deposit the base token of the system and take long or short positions. Guaranteeing the stability of the pegged tokens boils down to the problem of maintaining the peg of the virtual assets to real world assets, and the main mechanism used by Exeum is controlling the swap rate of assets. If the swap rate is fully controlled by the system, arbitrageurs can be incentivized enough to restore a broken peg; Exeum distributes statistical arbitrage trading software to decentralize this type of market making activity. The last major component of the system is a central bank equivalent that determines the long term interest rate of the base token, pays interest on the deposit by inflating the supply if necessary, and removes the need for stability fees on pegged tokens, improving their usability. To the best of our knowledge, Exeum is the first to propose a truly decentralized method for developing a stablecoin that enables 1:1 value conversion between the base token and pegged assets, completely removing the mismatch between supply and demand. In this paper, we will also discuss its applications, such as improving staking based DApp token models, price stable gas fees, pegging to an index of DApp tokens, and performing cross-chain asset transfer of legacy crypto assets.
Patterned piezo-, pyro-, and ferroelectricity of poled polymer electrets (2010)

Polymers with strong piezo-, pyro-, and ferroelectricity are attractive for a wide range of applications. In particular, semicrystalline ferroelectric polymers are suitable for a large variety of piezo- and pyroelectric transducers or sensors, while amorphous polymers containing chromophore molecules are particularly interesting for photonic devices. Recently, a new class of polymer materials has been added to this family: internally charged cellular space-charge polymer electrets (so-called “ferroelectrets”), whose piezoelectricity can be orders of magnitude higher than that of conventional ferroelectric polymers. Suitable patterning of these materials leads to improved or unusual macroscopic piezo-, pyro-, and ferroelectric or nonlinear optical properties that may be particularly useful for advanced transducer or waveguide applications. In the present paper, the piezo-, pyro-, and ferroelectricity of poled polymers is briefly introduced, an overview on the preparation of polymer electrets with patterned piezo-, pyro-, and ferroelectricity is provided and a survey of selected applications is presented.
Design and Realisation of Integrated Circuits for the Readout of Pixel Sensors in High Energy Physics and Biomedical Imaging (2004)

Several application specific microchips (ASICs) for the readout of pixel detectors have been designed, tested and described in this thesis. The first chapter gives the detailed description of the pixel-readout chip for the ATLAS pixel detector (FEI). The chip is now in operation as the innermost electronic component of the ATLAS detector. The chip for steering of DEPFET matrix (SWITCHER) is described in the second chapter. The chip is implemented in a high-voltage CMOS technology, it generates fast high voltage signals. Finally, a novel pixel readout chip for a hybrid x-ray pixel detector based on direct conversion is introduced. The chip (CIX) has joint photon counting and integrating capability.
Introduction: Civil War Voices and Views (2016)

Despite Walt Whitman’s doubts that the truth would ever be told about the American Civil War, the historian Louis P. Masur has taken the poet’s assertion that ‘the real war will never get in the books’ as the title for his own anthology, which confirms his assertion that it was a ‘written war.’...
A Compact Operational Amplifier with Load-Insensitive Stability Compensation for High-Precision Transducer Interface (2018)

High-resolution electronic interface circuits for transducers with nonlinear capacitive impedance need an operational amplifier, which is stable for a wide range of load capacitance. Such operational amplifier in a conventional design requires a large area for compensation capacitors, increasing costs and limiting applications. In order to address this problem, we present a gain-boosted two-stage operational amplifier, whose frequency response compensation capacitor size is insensitive to the load capacitance and also orders of magnitude smaller compared to the conventional Miller-compensation capacitor that often dominates chip area. By exploiting pole-zero cancellation between a gain-boosting stage and the main amplifier stage, the compensation capacitor of the proposed operational amplifier becomes less dependent of load capacitance, so that it can also operate with a wide range of load capacitance. A prototype operational amplifier designed in 0.13-μm complementary metal-oxide-semiconductor (CMOS) with a 400-fF compensation capacitor occupies 900- μ m 2 chip area and achieves 0.022-2.78-MHz unity gain bandwidth and over 65 ∘ phase margin with a load capacitance of 0.1-15 nF. The prototype amplifier consumes 7.6 μ W from a single 1.0-V supply. For a given compensation capacitor size and a chip area, the prototype design demonstrates the best reported performance trade-off on unity gain bandwidth, maximum stable load capacitance, and power consumption.
New Strategies for Electrochemical Nucleic Acid Detection (2002)

Electrochemical technologies have received increasing attention for development of biological assays. Electrochemical methods have the potential to allow for very low limits of detection if all of the analyte can be delivered efficiently to the electrode surface. In addition, the electroactivity of the nucleobases and sugars may provide a means by which the attachment of fluorescent and radioactive labels to target nucleic acids can be avoided.
Utilizing spare network bandwidth to improve TCP performance (2004)

It is well-known that TCP Reno represents a performance bottleneck as the delay-bandwidth product increases. On high-bandwidth-delay links, the additive increase policy of one packet every RTT necessitates thousands of RTTs to reach full link utilization. This severely affects short TCP flows (most of the flows in the internet) as they cannot acquire bandwidth faster than “slow start ” and waste precious RTTs ramping up even when bandwidth is available. XCP [2] addresses this problem by heavily modifying routers to explicitly tell the end-hosts about their fair share of network bandwidth. Fast-TCP [1] backs-off proactively without incurring any loss but cannot quickly ramp-up as the fair share increases. We propose an approach where a TCP stream can quickly use the full available link bandwidth without requiring modifications to router software. Our approach rapidly fills the bandwidth-delay pipe while being just as cautious as TCP in avoiding causing losses to existing streams. This is accomplished by sending a large number of low-priority packets in addition to the conservative number of normal-priority TCP packets. Routers would be configured for strict priority queuing (already supported by routers) where low priority packets are routed only when no normal priority packets are in the queue, and normal priority packets are dropped only when there are no low priority packets in the queue. A diffserv-style packet marking scheme can be used to distinguish between normal-priority and low-priority packets.
Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants# (2015)

Based on the clinical study results, a daily application of a toothpaste containing potassium nitrate, sodium monofluorophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin can significantly and quickly reduce tooth pain of dentin hypersensitivity.
Islet-1 Controls the Differentiation of Retinal Bipolar and Cholinergic Amacrine Cells (2007)

Whereas the mammalian retina possesses a repertoire of factors known to establish general retinal cell types, these factors alone cannot explain the vast diversity of neuronal subtypes. In other CNS regions, the differentiation of diverse neuronal pools is governed by coordinately acting LIM-homeodomain proteins including the Islet-class factor Islet-1 (Isl1). We report that deletion of Isl1 profoundly disrupts retinal function as assessed by electroretinograms and vision as assessed by optomotor behavior. These deficits are coupled with marked reductions in mature ON- and OFF-bipolar (>76%), cholinergic amacrine (93%), and ganglion (71%) cells. Mosaic deletion of Isl1 permitted a chimeric analysis of "wild-type" cells in a predominantly Isl1-null environment, demonstrating a cell-autonomous role for Isl1 in rod bipolar and cholinergic amacrine development. Furthermore, the effects on bipolar cell development appear to be dissociable from the preceding retinal ganglion cell loss, because Pou4f2-null mice are devoid of similar defects in bipolar cell marker expression. Expression of the ON- and OFF-bipolar cell differentiation factors Bhlhb4 and Vsx1, respectively, requires the presence of Isl1, whereas the early bipolar cell marker Prox1 initially did not. Thus, Isl1 is required for engaging bipolar differentiation pathways but not for general bipolar cell specification. Spatiotemporal expression analysis of additional LIM-homeobox genes identifies a LIM-homeobox gene network during bipolar cell development that includes Lhx3 and Lhx4. We conclude that Isl1 has an indispensable role in retinal neuron differentiation within restricted cell populations and this function may reflect a broader role for other LIM-homeobox genes in retinal development, and perhaps in establishing neuronal subtypes.
In-situ measurement of impedance of die power delivery system (2005)

The modified method of measurement of impedance of die power delivery system is presented. In contrast to the previous approach, the proposed methodology includes a new method of detailed reconstruction of the on-chip current for a step-wise computer process. The new methodology is based on representation of a chip as a variable resistor. The measurement results show the most pronounced difference between the new and previous methodologies in the frequency regions of power delivery resonances. The difference is higher for chips with higher Q-factors.