gebhart/patrepeval huggingface dataset:
Crosslinking of caseins by human placental factor XIIIa (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleCrosslinking of caseins by human placental factor XIIIaFatoumata Traore and Jean Claude MeunierCite this: J. Agric. Food Chem. 1991, 39, 10, 1892–1896Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/jf00010a042https://doi.org/10.1021/jf00010a042research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<i>In vitro</i>and<i>in vivo</i>rescue of aberrant splicing in<i>CEP290</i>-associated LCA by antisense oligonucleotide delivery (2016)

Leber congenital amaurosis (LCA) is a severe disorder resulting in visual impairment usually starting in the first year of life. The most frequent genetic cause of LCA is an intronic mutation in CEP290 (c.2991 + 1655A > G) that creates a cryptic splice donor site resulting in the insertion of a pseudoexon (exon X) into CEP290 mRNA. Previously, we showed that naked antisense oligonucleotides (AONs) effectively restored normal CEP290 splicing in patient-derived lymphoblastoid cells. We here explore the therapeutic potential of naked and adeno-associated virus (AAV)-packaged AONs in vitro and in vivo In both cases, AON delivery fully restored CEP290 pre-mRNA splicing, significantly increased CEP290 protein levels and rescued a ciliary phenotype present in patient-derived fibroblast cells. Moreover, administration of naked and AAV-packaged AONs to the retina of a humanized mutant Cep290 mouse model, carrying the intronic mutation, showed a statistically significant reduction of exon X-containing Cep290 transcripts, without compromising the retinal structure. Together, our data highlight the tremendous therapeutic prospective of AONs for the treatment of not only CEP290-associated LCA but potentially many other subtypes of retinal dystrophy caused by splicing mutations.
Robust odometry estimation for RGB-D cameras (2013)

The goal of our work is to provide a fast and accurate method to estimate the camera motion from RGB-D images. Our approach registers two consecutive RGB-D frames directly upon each other by minimizing the photometric error. We estimate the camera motion using non-linear minimization in combination with a coarse-to-fine scheme. To allow for noise and outliers in the image data, we propose to use a robust error function that reduces the influence of large residuals. Furthermore, our formulation allows for the inclusion of a motion model which can be based on prior knowledge, temporal filtering, or additional sensors like an IMU. Our method is attractive for robots with limited computational resources as it runs in real-time on a single CPU core and has a small, constant memory footprint. In an extensive set of experiments carried out both on a benchmark dataset and synthetic data, we demonstrate that our approach is more accurate and robust than previous methods. We provide our software under an open source license.
RGB-D fusion toward accurate 3D mapping (2011)

Recently announced RGB-D cameras like Microsoft Kinect are attractive sensing systems providing RGB images along with registered depth information at a high frame rate. This advantage makes such cameras greatly useful in the context of robotics, especially for dense 3D mapping in home environment. However, depth information they provide is usually incomplete and imprecise. This paper presents a method that effectively rectifies depth maps, particularly for missing regions, via fusion of 2D-3D images. Segmentation for plane fitting as well as Markov random field based optimization are applied successively to achieve our objective. We test our algorithm on a range of data with varying kinds and amount of incompleteness.
Acceleration of Large Integer Multiplication with Intel AVX-512 Instructions (2018)

In this paper, we propose an implementation of large integer multiplication using Single Instruction Multiple Data (SIMD) instructions. We evaluated the implementation on an Intel Xeon Phi processor. The second generation Intel Xeon Phi processor, Knights Landing, has a set of Advanced Vector Extensions-512 (AVX-512) instructions. Using AVX-512, the processor can handle 512 bits at the same time and has the potential to multiply faster than a processor using Streaming SIMD Extensions (SSE) and AVX. Therefore, we applied AVX-512F (foundation) instructions to the program. In the multiplication of large integers, as the number of digits increases, various processing costs also become larger. One of these costs is carry processing. Therefore, we implemented a multiplication function using a reduced-radix representation and compared the execution time and the number of instructions against the GNU Multiple Precision Arithmetic Library (GMP). Furthermore, we used some optimization techniques for this kernel. We successfully achieved an execution time that was approximately 2.5x faster than GMP on the Knights Landing architecture.
Selective covalent labeling of cysteines in bovine serum albumin and in hepatoma tissue culture cell glucocorticoid receptors by dexamethasone 21-mesylate. (1987)

The specificity of protein labeling by an affinity label of glucocorticoid receptors, dexamethasone 21-mesylate (Dex-Mes), was investigated using bovine serum albumin (BSA) as a model. During the early stages of [3H]Dex-Mes labeling at pH 8.8, approximately 90% of the covalent bond formation occurred at the one non-oxidized cysteine (Cys-34) of BSA. The nonspecific labeling was equally distributed over the rest of the BSA molecule. [3H]Dex-Mes labeling of Cys-34 was totally, and specifically inhibited by nearly stoichiometric amounts of the thiol-specific reagent methyl methanethiolsulfonate (MMTS). Thus both Dex-Mes and MMTS appear to react very selectively with thiols under our conditions. In reactions with hepatoma tissue culture (HTC) cell glucocorticoid receptors, MMTS was equally efficient in preventing [3H]dexamethasone binding to receptors and [3H]Dex-Mes labeling of the 98-kDa receptor protein. These results indicate that Dex-Mes labeling of the glucocorticoid receptor involves covalent reaction with at least one cysteine in the steroid binding site of the receptor. Small (approximately 1600-dalton) fragments of the [3H]Dex-Mes-labeled 98-kDa receptor were generated by limit proteolysis with trypsin, chymotrypsin, and Staphylococcus aureus V8 protease under denaturing conditions. Data from these fragments on 15% sodium dodecyl sulfate-polyacrylamide gels were consistent with all of the covalent [3H] Dex-Mes being located on one or a few cysteines in one approximately 15-residue stretch of the receptor. Further studies revealed no differences in the limit protease digestion patterns of activated and unactivated [3H]Dex-Mes-labeled receptors with trypsin, chymotrypsin, or V8 protease under denaturing conditions. These data suggest that activation does not cause any major covalent modifications of the amino acids immediately surrounding the affinity-labeled cysteine(s) of the steroid binding site.
Molecular mechanisms of biomass increase in plants (2017)

Biomass consumption continues to increase worldwide for the provision of human energy needs. These high pressures for energy will determine the demand for crop plants as a resource for biofuel, heat and electricity. Thus, the search for plant traits associated with genetic increases in yield is unconditional. Here, we propose exploiting recent advances in plant biomass enhancement in non-crop as well as in crop plants. For this purpose, biotechnological approaches that are well known rapid ways of enhancing the plant traits, as well as the traditional way of improving plants through plant breeding selecting for desirable phenotypes are excellent techniques to improve plant biomass and reduce the dependence on fossil fuels. Obviously, many genes can be associated with promising phenotypes however this review will focus on genes selected from different plant networks. Keywords: Biomass, Yield, Biotechnology, Crops, Cell cycle
Effectiveness of removal of aqueous perchlorate by Cuprilig, a copper(II) derivative of Octolig<sup>®</sup> (2009)

The present study describes the effectiveness of removal of perchlorate ion by Octolig a commercially available immobilized ligand, IMLIG, and by Cuprilig, the cupric ion derivative of this material. Octolig consists of polyethylenediamine moieties covalently bound to a high-surface area silica gel (CAS Registry number = 404899-06-5). Perchlorate in drinking water is a nuisance anion that escapes from firms that produce rocket fuel, batteries, and fireworks and becomes a contaminant of groundwater. It may also be a natural component of the environment. Perchlorate ion can interfere with thyroid function and may also cause birth defects. Perchlorate contamination of water supplies is serious because of the difficulty in removing it, especially in the western United States where a combination of drought and water shortages exacerbate the problems of supplying safe drinking water to an increasing population. In this study, aqueous solutions were passed over a chromatography column containing samples of Cuprilig. Test water contained 70 microg perchlorate/L and effluent was below detection level (< 1 microg/L. Equally good results were obtained for Octolig in deionized water and in well water. Analyses were performed by a commercial laboratory. Mechanisms of interaction are proposed.
Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth (2021)

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase both result in decreased production of cyclic GMP in chondrocytes and severe short stature, causing achondroplasia (ACH) and acromesomelic dysplasia, type Maroteaux, respectively. Previously, we showed that an NPR2 agonist BMN-111 (vosoritide) increases bone growth in mice mimicking ACH (Fgfr3Y367C/+). Here, because FGFR3 signaling decreases NPR2 activity by dephosphorylating the NPR2 protein, we tested whether a phosphatase inhibitor (LB-100) could enhance BMN-111-stimulated bone growth in ACH. Measurements of cGMP production in chondrocytes of living tibias, and of NPR2 phosphorylation in primary chondrocytes, showed that LB-100 counteracted FGF-induced dephosphorylation and inactivation of NPR2. In ex vivo experiments with Fgfr3Y367C/+ mice, the combination of BMN-111 and LB-100 increased bone length and cartilage area, restored chondrocyte terminal differentiation, and increased the proliferative growth plate area, more than BMN-111 alone. The combination treatment also reduced the abnormal elevation of MAP kinase activity in the growth plate of Fgfr3Y367C/+ mice and improved the skull base anomalies. Our results provide a proof of concept that a phosphatase inhibitor could be used together with an NPR2 agonist to enhance cGMP production as a therapy for ACH.
ESD events in SiN RF-MEMS capacitive switches (2009)

This paper deals with TLP and HBM test results for RF-MEMS capacitive switches. The methodology for each ESD testing simulator is commented, taking into account the accordance between the test bench and the device-under-test. The failure criteria of the tested structures are reported, showing their breakdown process under ESD.
Ultraviolet photofragmentation of biomolecular ions (2009)

Mass spectrometric identification of all types of molecules relies on the observation and interpretation of ion fragmentation patterns. Peptides, proteins, carbohydrates, and nucleic acids that are often found as components of complex biological samples represent particularly important challenges. The most common strategies for fragmenting biomolecular ions include low- and high-energy collisional activation, post-source decay, and electron capture or transfer dissociation. Each of these methods has its own idiosyncrasies and advantages but encounters problems with some types of samples. Novel fragmentation methods that can offer improvements are always desirable. One approach that has been under study for years but is not yet incorporated into a commercial instrument is ultraviolet photofragmentation. This review discusses experimental results on various biological molecules that have been generated by several research groups using different light wavelengths and mass analyzers. Work involving short-wavelength vacuum ultraviolet light is particularly emphasized. The characteristics of photofragmentation are examined and its advantages summarized.
Silicon-Based Photonic Integration Beyond the Telecommunication Wavelength Range (2014)

In this paper we discuss silicon-based photonic integrated circuit technology for applications beyond the telecommunication wavelength range. Silicon-on-insulator and germanium-on-silicon passive waveguide circuits are described, as well as the integration of III-V semiconductors, IV-VI colloidal nanoparticles and GeSn alloys on these circuits for increasing the functionality. The strong nonlinearity of silicon combined with the low nonlinear absorption in the mid-infrared is exploited to generate picosecond pulse based supercontinuum sources, optical parametric oscillators and wavelength translators connecting the telecommunication wavelength range and the mid-infrared.
Human ESC-derived Neural Rosettes and Neural Stem Cell Progression (2008)

Y. Elkabetz and L. Studer Developmental Biology Program, Division of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10065 Correspondence: studerl{at}mskcc.org
The multiple prime random number generator (1987)

A new pseudorandom number generator, the Multiple Prime Random Number Generator, has been developed; it is efficient, conceptually simple, flexible, and easy to program. The generator utilizes cycles around prime numbers to guarantee the length of the period, which can easily be programmed to surpass the maximum period of any other presently available random number generator. There are minimum limits placed on the seed values of the variables because the period of the generator is not a function of the initial values of the variables. The generator passes thirteen standard random number generator tests. It requires only about fifteen lines of FORTRAN code to program and utilizes programming language constructs found in most major languages. Finally, it compares very favorably to the fastest of the other available generators.
Smart Materials Systems: Emerging Automotive Applications (1995)

(1995). Smart Materials Systems: Emerging Automotive Applications. Materials Technology: Vol. 10, No. 7-8, pp. 159-162.
Ultrafast photonic interfaces for storage networking using serial-to-parallel and parallel-to-serial conversion (2003)

We propose novel ultrafast photonic interfaces for use in storage networking based on all-optical serial-to-parallel and photonic parallel-to-serial conversion. We confirm their operation with 40-Gbit/s 16-bit optical data using compact modules and a potential bandwidth of over 100 Gbit/s. We realize a photonic random access memory (RAM) by sandwiching a CMOS RAM with these two interfaces and achieve the storage and read-out of 40-Gbit/s 16-bit optical data. We also discuss the advantages of the interfaces and their possible applications to storage networking such as the real-time remote back-up of huge quantities of data, disaster recovery and video communication systems.
High accurate timestamping by phase and frequency estimation (2009)

When using network synchronization protocols like IEEE 1588 or NTP, a common approach to increase the performance is to add hardware support for timestamping the essential synchronization messages. Further, timestamping accuracy and the stability of the local oscillator of a network synchronized node are the two main influence factors for high accuracy clock synchronization. While the latter is subject to manufacturing technologies, the first is mainly given by the design of the packet timestamper of the node. While common solutions use sampling in minimized intervals to achieve high accuracy, this paper lists other approaches and proposes a method based on phase/frequency estimation. While the additional hardware effort is rather low, the presented method allows for high accuracy. The performance of the developed design is equivalent to a 5.5 GHz sampling clock, but still can be implemented even in low cost digital logic devices.
Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich’s ataxia (2017)

Friedreich's ataxia (FRDA) is an incurable autosomal recessive neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin due to an intronic GAA-repeat expansion in the <i>FXN</i> gene. We report the therapeutic efficacy of transplanting wild-type mouse hematopoietic stem and progenitor cells (HSPCs) into the YG8R mouse model of FRDA. In the HSPC-transplanted YG8R mice, development of muscle weakness and locomotor deficits was abrogated as was degeneration of large sensory neurons in the dorsal root ganglia (DRGs) and mitochondrial capacity was improved in brain, skeletal muscle, and heart. Transplanted HSPCs engrafted and then differentiated into microglia in the brain and spinal cord and into macrophages in the DRGs, heart, and muscle of YG8R FRDA mice. We observed the transfer of wild-type frataxin and Cox8 mitochondrial proteins from HSPC-derived microglia/macrophages to FRDA mouse neurons and muscle myocytes in vivo. Our results show the HSPC-mediated phenotypic rescue of FRDA in YG8R mice and suggest that this approach should be investigated further as a strategy for treating FRDA.
IL6/IL6R genetic diversity and plasma IL6 levels in bipolar disorder: An Indo-French study (2019)

Reports of association of genetic variants of <i>IL6</i> and its receptor (<i>IL6R</i>) with psychiatric disorders are inconsistent, and there are few population-based studies thus far in bipolar disorder (BD). We genotyped the <i>IL6 rs</i>1800795 and <i>IL6R rs</i>2228145 polymorphisms in two independent sets of patients exposed to different environmental stimuli such as climatic conditions or specific infectious burden - a French sample and a south Indian Tamil sample of BD with quantitation of circulating plasma IL-6 levels in the latter sub-sample. In both populations, allele and genotype frequencies did not differ significantly between cases and controls for either polymorphism. Upon stratifying based on age at onset, we found no associations with the <i>IL6 rs</i>1800795 variant. However, the <i>IL6R rs</i>2228145 C allele and CC genotype were associated with early onset of disease in the French sample when compared to late onset BD. A similar trend was observed in the Indian population where we also found that plasma IL-6 levels were significantly higher in BD and also in patients who were in residual phase or remission both as compared to controls. Our findings are in favour of a possible trans-ethnic implication of the IL6R genetic diversity in BD and reinforce the notion that IL-6 is an important marker of the operating inflammatory processes in the disease.
[Quantification of cerebral circulation using duplex sonography]. (1987)

An attempt was made to measure quantitatively the total cerebral blood flow by means of Duplex sonography. In a group of healthy young subjects a median value for total cerebral blood flow was obtained amounting to 469 ml/min +/- 30%; repeat measurements yielded a maximum deviation of +/- 11%. In three patients the values obtained after severe apoplectic insult due to occlusion of the internal carotid artery were definitely below the value of the group of healthy subjects, whereas the value for the total blood flow was in the upper range of normal values in a patient with occlusion of the a. cerebri media. Comparative measurements of the regional cerebral blood flow with xenon 133 yielded in those patients with occlusion of the internal carotid artery a markedly reduced mean flow and in the patient with occlusion of the a, cerebri media a less markedly reduced mean flow. Regionally reduced perfusion was seen in all the four patients in the range of the clinically and computer tomographically well-known ischaemia zone. Thanks to the simplicity of this sonographic examination method it could be a useful decision parameter in determining the indication for a reconstruction of the carotid artery, especially in asymptomatic patients.
Synchrony and Desynchrony in Integrate-and-Fire Oscillators (1999)

Due to many experimental reports of synchronous neural activity in the brain, there is much interest in understanding synchronization in networks of neural oscillators and its potential for computing perceptual organization. Contrary to Hopfield and Herz (1995), we find that networks of locally coupled integrate-and-fire oscillators can quickly synchronize. Furthermore, we examine the time needed to synchronize such networks. We observe that these networks synchronize at times proportional to the logarithm of their size, and we give the parameters used to control the rate of synchronization. Inspired by locally excitatory globally inhibitory oscillator network (LEGION) dynamics with relaxation oscillators (Terman & Wang, 1995), we find that global inhibition can play a similar role of desynchronization in a network of integrate-and-fire oscillators. We illustrate that a LEGION architecture with integrate-and-fire oscillators can be similarly used to address image analysis.
A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells (1995)

Translocations involving chromosomal band 11q23 are associated with leukemias. These translocations fuse the MLL, a gene with sequence homology to the Drosophila trithorax, to genes from a number of other chromosomal loci. We have characterized two t(1;11)(q21;q23) translocations that fuse the MLL gene to a novel gene, AF1q on chromosomal band 1q21, in two infants with acute myelomonocytic leukemia (AMMOL). In one of these patients, der(11) represents an inframe fusion of the N-terminal portion of MLL gene to the complete AF1q open reading frame, whereas der(1) does not give rise to an open reading frame. This observation suggests that the N-terminal portion of MLL gene is critical for leukemogenesis in translocations involving band 11q23. The predicted wild-type AF-1q product is a 9-kD protein with no similarity to any other protein in the data banks. The AF1q mRNA is highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, AF1q was expressed in all leukemic cell lines tested.