gebhart/patrepeval huggingface dataset:
Effect of long-term exercise on age-related changes in rats. (1992)

The effect of long-term exercise on the onset and progression of age-related pathological changes in male and female Wistar rats was studied. Male and female Wistar rats immediately after weaning were assigned to a voluntary wheel running group. Two year exercise reduced the body weight gains of both sexes and improved the survival curves in males. Histopathologically, the exercise was more effective than freely eating sedentary control in the reduction of chronic nephropathy and anterior adenoma of pituitary, which are major fatal age-related changes in rats. The exercised rats showed low incidences of skeletal muscle fibrosis and mammary tumors. These results suggested that voluntary exercise for 2 years reduced the occurrence of age-related changes, and these effects were related with suppression of body weight gains.
ThermalSense (2016)

We present ThermalSense, a method for dynamically detecting and predicting thermal comfort by using thermographic imaging to look for the physiological markers of vasodilation or vasoconstriction. We describe how ThermalSense can be used to infer how to control heating and cooling systems and reduce energy use while maintaining comfort.
Health Differentials between Blacks and Whites: Recent Trends in Mortality and Morbidity (1987)

Kenneth G. Manton, Clifford H. Patrick, Katrina W. Johnson, Health Differentials between Blacks and Whites: Recent Trends in Mortality and Morbidity, The Milbank Quarterly, Vol. 65, Supplement 1 (Part 1). Currents of Health Policy: Impacts on Black Americans (1987), pp. 129-199
Stochastic Joint Radio and Computational Resource Management for Multi-User Mobile-Edge Computing Systems (2017)

Mobile-edge computing (MEC) has recently emerged as a prominent technology to liberate mobile devices from computationally intensive workloads, by offloading them to the proximate MEC server. To make offloading effective, the radio and computational resources need to be dynamically managed, to cope with the time-varying computation demands and wireless fading channels. In this paper, we develop an online joint radio and computational resource management algorithm for multi-user MEC systems, with the objective as minimizing the long-term average weighted sum power consumption of the mobile devices and the MEC server, subject to a task buffer stability constraint. Specifically, at each time slot, the optimal CPU-cycle frequencies of the mobile devices are obtained in closed forms, and the optimal transmit power and bandwidth allocation for computation offloading are determined with the Gauss-Seidel method; while for the MEC server, both the optimal frequencies of the CPU cores and the optimal MEC server scheduling decision are derived in closed forms. Besides, a delay-improved mechanism is proposed to reduce the execution delay. Rigorous performance analysis is conducted for the proposed algorithm and its delay-improved version, indicating that the weighted sum power consumption and execution delay obey an $\left[O\left(1\slash V\right),O\left(V\right)\right]$ tradeoff with $V$ as a control parameter. Simulation results are provided to validate the theoretical analysis and demonstrate the impacts of various parameters.
Cerebral glucose metabolism in aging rodents: effects of co-dergocrine. (1985)

Because glucose is the primary substrate for oxidative metabolism of the adult brain, measurements of glucose utilization provide information on cerebral energy metabolism, which ultimately is linked to neuronal activity. Early studies utilized in vitro techniques to measure carbohydrate oxidation as well as glycolytic and citric acid cycle enzymatic activities as a function of age. Although the results of these studies are somewhat equivocal, they generally indicate a decline in cerebral carbohydrate metabolism in senescent rodents. More recently, local cerebral glucose utilization (LCGU) has been measured in awake, resting rats with the 2-deoxy-D[1-14C]glucose metabolic mapping technique. Using this technique, decrements in LCGU have been observed in rats by midlife. Co-dergocrine, an ergot alkaloid used extensively in geriatric psychopharmacology, reversed subcortical LCGU decrements in brain areas associated with motor function, motivation, and learning. In contrast, the drug decreased frontal cortical LCGU in middle-aged rats. Stimulatory effects of co-dergocrine on LCGU in brain areas associated with motivation and learning support the view that the drug may be useful against age-associated disorders of cognition. Furthermore, the co-dergocrine-induced decrease in cortical glucose utilization coupled with the drug's cerebral vasoconstrictive action may render cortical cells less susceptible to the sequelae of ischemia.
Structural host-microbiota interaction networks (2017)

Hundreds of different species colonize multicellular organisms making them "metaorganisms". A growing body of data supports the role of microbiota in health and in disease. Grasping the principles of host-microbiota interactions (HMIs) at the molecular level is important since it may provide insights into the mechanisms of infections. The crosstalk between the host and the microbiota may help resolve puzzling questions such as how a microorganism can contribute to both health and disease. Integrated superorganism networks that consider host and microbiota as a whole-may uncover their code, clarifying perhaps the most fundamental question: how they modulate immune surveillance. Within this framework, structural HMI networks can uniquely identify potential microbial effectors that target distinct host nodes or interfere with endogenous host interactions, as well as how mutations on either host or microbial proteins affect the interaction. Furthermore, structural HMIs can help identify master host cell regulator nodes and modules whose tweaking by the microbes promote aberrant activity. Collectively, these data can delineate pathogenic mechanisms and thereby help maximize beneficial therapeutics. To date, challenges in experimental techniques limit large-scale characterization of HMIs. Here we highlight an area in its infancy which we believe will increasingly engage the computational community: predicting interactions across kingdoms, and mapping these on the host cellular networks to figure out how commensal and pathogenic microbiota modulate the host signaling and broadly cross-species consequences.
Knitting a 3D Model (2008)

Abstract A knitted animal is made of a closed surface consisting of several knitted patches knitted out of yarn and stuffed with cotton ( Fig. 1 ). We introduce a system to create a knitting pattern from a given 3D surface model (mainly designed for rotund animal models). A knitting pattern is an instructional diagram describing how to knit yarn to obtain a desired shape. Since the creation of knitting patterns requires special skill, this is difficult for nonprofessionals. Our system automates the process and allows anyone to obtain his or her original knitting patterns from a 3D model. The system first covers the surface of the model with parallel winding strips of constant width. The system then samples the strip at constant intervals to convert it into a knitting pattern. The result is presented in a standard visual format so that the user can easily refer it during actual knitting. We show several examples of knitted animals created using the system. Example of a knitted animal. A typical knitted animal consists of several circular and cylindrical patches. image
Behavior-based relative self-localization in intersection scenarios (2017)

Accurate map-relative localization is crucial when dealing with navigation or other driver assistance tasks. Global Navigation Satellite Systems (GNSS), such as GPS, GLONASS or Galileo, meet the requirements demanded from road-level navigation systems, but with lane-level assistance being the next step, more accurate localization technologies are needed. A lot of effort has been put in improving localization relative to lanes in scenarios with simple road geometry, whereas more complex scenarios such as intersections have received less attention, even though being a key factor in navigational tasks. In this paper, we focus on self-localization in the vicinity of intersections by using the trajectories of other cars as spatial cue. The geometry of the considered intersections as well as the ideal routes of cars traversing the intersection are derived from enhancements of freely available and crowdsourced map data. The trajectory of each car is compared to possible intersection routes in order to find the route which most likely corresponds to the actual trajectory. Subsequently, a geometrical transformation is computed to align the trajectory to the corresponding route and to estimate the position of the ego-vehicle with respect to the intersection. The feasibility of the approach is demonstrated on multiple scenes from the KITTI Benchmark Dataset [1]. We show that the presented approach is suitable for self-localization in intersection scenarios.
A Comparison of Daily Average Consumption Of Oxycodone Controlled Release (OxyContin CR) And Oxymorphone Extended Release (Opana ER) In Patients With Low Back Pain. (2011)

The use of oxycodone CR, measured as mean daily consumption over a 90-day period, was significantly higher than that for oxymorphone ER in these patients, a finding that could have financial implications for health care systems.
In-DRAM Bulk Bitwise Execution Engine (2019)

Many applications heavily use bitwise operations on large bitvectors as part of their computation. In existing systems, performing such bulk bitwise operations requires the processor to transfer a large amount of data on the memory channel, thereby consuming high latency, memory bandwidth, and energy. In this paper, we describe Ambit, a recently-proposed mechanism to perform bulk bitwise operations completely inside main memory. Ambit exploits the internal organization and analog operation of DRAM-based memory to achieve low cost, high performance, and low energy. Ambit exposes a new bulk bitwise execution model to the host processor. Evaluations show that Ambit significantly improves the performance of several applications that use bulk bitwise operations, including databases.
<sup>13</sup>C NMR study of the substituent effects on the internal steric hindrances in amidines (1989)

Abstract 13 C NMR spectra of ten formamidines, five acetamidines and five butyramidines were recorded at low temperatures. The barrier to rotation around the CN 1 bond for N 2 ‐alkylformamidines is approximately 50 kJ mol −1 and for N 2 ‐benzylformamidines approximately 52 kJ mol −1 , and is thus ca. 10 kJ mol −1 lower than for N 2 ‐phenylformamidines. The height of the barrier is related to Taft's substituent constants at N 2 , δG* = 49.25 + 8.08σ* −3.21 E s . In the acetamidines the steric hindrance between the alkyl substituent at N 2 with C F CH 3 contributed to the decrease in δ* (lower than 40 kJ mol −1 ). The i ‐C 3 H 7 substituent at C F in butyramidines forces isomerization and these amidines become Z isomers. MNDO calculations indicate no significant changes of bond length on E / Z isomerization, and the low rotational barrier in butyramidines is probably caused by the steric interaction of the aromatic ring at N 2 with the N 1 (CH 3 ) 2 group.
Characterization of the Hemodynamic Response to Intravenous Diaspirin Crosslinked Hemoglobin Solution in Rats (1994)

Diaspirin crosslinked hemoglobin solution (DCLHB) has potential for clinical use as an oxygen-carrying solution because of its excellent oxygen transport properties and biochemical stability. The present study characterizes the effects of intravenous infusions of 0.625-40 mL/kg (62.5-4000 mg/kg) DCLHb on mean blood pressure (MAP) and heart rate (HR) in conscious rats. DCLHb at all doses tested except 62.5 mg/kg was associated with an immediate increase in MAP (25-30% above baseline) that peaked between 20-30 minutes after infusion and returned to baseline within 120-300 minutes in a dose-dependent manner. Maximum MAP achieved was in the range of 129 +/- 7 to 140 +/- 7 mm Hg and there was no statistically significant difference in the response between doses. HR responded in a reciprocal manner to changes in MAP. Volume- and oncotic-matched infusions of LR and albumin did not alter MAP or HR. Slow infusion (0.34 mL/min) of DCLHb appeared to blunt the magnitude of the pressor response when compared to bolus injection (< 10 sec). DCLHb administration is associated with a pressor response that is not due to volume load, oncotic pressure, or rate of infusion, suggesting that it is intrinsic to the modified hemoglobin molecule and pharmacologic in nature.
Renal manifestations of sarcoidosis (1981)

• Sarcoidosis may involve the kidneys in several ways. Most commonly, aberrations of calcium metabolism, including hypercalcemia, hypercalciuria, and nephrocalcinosis, are responsible for the renal manifestations of sarcoidosis. Granulomatous infiltration of the renal interstitium may also produce severe derangements of renal function. Glomerulonephritis can occur with sarcoidosis, although the pathogenesis remains unclear. Besides renal insufficiency and frank renal failure, nephrotic syndrome, nephrolithiasis, hypertension, and a variety of tubular defects may complicate sarcoidosis. The sensitivity of "sarcoid nephropathy" to corticosteroids usually warrants a therapeutic trial. (<i>Arch Intern Med</i>1981;141:643-645)
Development of Complementary Metal Oxide Semiconductor Imaging Devices for Detecting Green Fluorescent Protein in the Deep Brain of a Freely Moving Mouse (2009)

We have developed to observe neural activities in the deep brain of a freely moving mouse with green fluorescent protein (GFP). We implanted a dedicated complementary metal oxide semiconductor (CMOS) imaging device into the hippocampus or the basal ganglion of an anesthetized mouse to confirm the effectiveness of the CMOS imaging device for the detection of GFP generated in the deep brain of the anesthetized mouse. Moreover, we conducted an experiment to demonstrate the capability of the CMOS imaging device to detect GFP in the deep brain of a freely-moving mouse. As a result of the in vivo experiments with two methods of GFP expression, we successfully detected the light intensity of GFP in the hippocampus or the basal ganglion of the anesthetized mouse. Furthermore, we demonstrated that the implanted CMOS imaging device operated well in the freely moving mouse after one week from implantation. We demonstrated the basic technology to realize the observation of neural activities in the deep brain of a freely moving mouse.
The Effects of Genistein on the Proliferation and Type I pN Collagen Synthesis in Aged Normal Human Fibroblasts (2007)

We studied the effects of genistein obtained from glycolysis of genistin, a kind of phytoestrogen present in soybeans, on cell proliferation and type I pN collagen synthesis in normal human dermal fibroblasts(NHDF). Cell proliferation was increased significantly with genistein treatment at 54-year aged NHDF. Genistein increased cell proliferation more strongly in cells form old doner than young doner. The senescence-associated -galatosidase activity was decreased in NHDF from 77-year old doner with genistein treatment. Type I pN collagen synthesis was increased with genistein treatement in UVA treated and non-treated NHDF. The increasement of collagen synthesis was more effective in aged cells than young cells. Type I pN collagen synthesis was also increased with genistein treatment in collagen matrix culture with NHDF from sun-exposed and non-exposed skin from 54-year old doner. Genistein treatment inhibited MMP-1 synthesis in old NHDF but not in young NHDF. In conclusion, genistein may be a useful agent for preventing intrinsic aging as well as photoaging.
WAVELENGTH DEPENDENCE OF INACTIVATION and MUTAGENESIS IN HAPLOID YEAST CELLS OF DIFFERENT SENSITIVITIES (1983)

Abstract The wavelength dependence of inactivation and mutagenesis in the range between 254 and 313 nm was investigated in haploid cells of the yeast Saccharomyces cerevisiae. The action spectra for a wild type and an excision deficient mutant essentially corresponded to those for bacteria and mammalian cells. There were, however, minor differences. The ratio of mutagenic to lethal action decreased with increasing wavelength in the wild type, but remained constant in the excision deficient mutant. This is discussed in terms of error‐prone and erro‐free repair. For both inactivation and mutagensis, photorcactivability was lower with longer wavelengths in the wild type, but did not change in the excision deficient mutant. Implications for the role of pyrimidine dimers are considered.
Learning semantic hierarchy with distributed representations for unsupervised spoken language understanding (2015)

We study the problem of unsupervised ontology learning for semantic understanding in spoken dialogue systems, in particular, learning the hierarchical semantic structure from the data. Given unlabelled conversations, we augment a frame-semantic based unsupervised slot induction approach with hierarchical agglomerative clustering to merge topically-related slots (e.g., both slots “direction” and “locale” convey location-related information) for building a coherent semantic hierarchy, and then estimate the slot importance at different levels. The high-level semantic estimation involves not only within-slot but also crossslot relations. The experiments show that high-level semantic information can accurately estimate the prominence of slots, significantly improving the slot induction performance; furthermore, a semantic decoder trained on the data with automatically extracted slots achieves about 68% F-measure, which is close to the one from hand-crafted grammars.
Prediction of Hydrostatic Pressure and Blood Penetration of Medical Protective Clothing (2016)

Disposable materials enjoy annually steady growth in volume in the field of medical applications as surgical gowns, isolation gowns, and medical drapes which impede cross contamination from reusable protective apparel in a hospital. There are four levels of liquid barrier performance according to the American National Standard/Association for the Advancement of Medical Instrumentation (ANSI/AAMI) PB70:2012 in terms of liquid impact penetration, hydrostatic pressure or hydrohead, and blood penetration. Different areas in a surgical gown require different levels of liquid barrier performance. Laminates of spunbond (SB), meltblown (MB), and spunbond (SB), called SMS fabric, and laminates of a porous membrane with a nonwoven fabric, usually with the SB layer for strength and ease of handling, are widely used as medical protective clothing. SMS materials are usually made to achieve up to Level 3, which requires a hydrostatic pressure of greater than 50 cm tested according to ANSI/AAMI PB70:2012. Above that level, Level 4 requires the liquid barrier to resist penetration by blood, in which case a laminate with a porous membrane is necessary. In this paper, the pore size, calculated from the fluid flow through a fibrous media, was used to estimate the hydrostatic pressure. The hydrostatic pressure was then used to correlate with the resistance of the media to blood penetration. The agreement of experimental and calculated data indicated that these theories were successful not only in predicting the pore size and the hydrostatic pressure of a fibrous material but also in correlating the hydrostatic pressure and blood penetration. The fiber fineness required to resist the penetration of blood was also calculated.
Specific regulation of HSPs in human tumor cell lines by PSK. (1997)

Substantial progress has been make in elucidating the biochemical properties of HSPs (Heat Shock Proteins) as molecular chaperones in protein biogenesis and their roles in thermoprotection and cytoprotection against cellular insults. Recently, besides advantageous cellular functions, the detrimental role of HSPs has been implicated in a variety of diseases. HSP47 is assumed to be a collagen specific molecular chaperone and its involvement in the progression of fibrosis was observed. There have been a number of reports that suggest the role of HSP60 as an autoantigen in a variety of autoimmune diseases. PSK, a protein-bound polysaccharide, is a biological response modifier that is clinically used for the treatment of cancer patients in Japan. PSK shows a broad range of biological effects in addition to the antitumor activity. In this study, we evaluated the effect of PSK on the expression of HSPs in human tumor strains at the protein and mRNA levels. PSK was observed to suppress the expression of HSP47 and HSP60 but not HSP72/73 in human tumor cell lines. Thus, the novel pharmacological potential of PSK was suggested in the diseases derived from the aberrant expression of HSPs.
DMSO (Me2SO) concentrations of 1-2% in combination with pentaisomaltose are effective for cryopreservation of T cells (2021)

T cell based treatments in the setting of allogenic haematopoietic stem cell transplantation (HSCT) have been used for decades. In addition, the use of chimeric antigen receptor (CAR) T cells has been introduced as a promising cancer immunotherapy. A prerequisite for many of these treatments is the ability to cryopreserve the cells safely and efficiently. In the present study, we compared freezing media combinations containing pentaisomaltose and 1-2 % DMSO (PIM1 and PIM2, respectively) to 10 % DMSO and commercially available cryosolutions (CS2 and CS10, Cryostor® containing 2 and 10 % DMSO, respectively) for cryopreservation of T cells. T cells isolated from buffy coats from healthy donors were cryopreserved with different freezing media and analysed for 1) viability immediately post-thaw and the following 24 h, 2) recovery, 3) proliferative potential and 4) migration towards a gradient of SDF-1α. The results showed that PIM2 was superior to 10 % DMSO and comparable to CS10 when assessing viability. Furthermore, the results indicated that the T cells cryopreserved with 10 % DMSO showed the lowest proliferative potential. The expression levels of CXCR3, CXCR4 and VLA-4 were similar in T cells independent of the freezing media used; however, T cells cryopreserved with PIM2 demonstrated the highest migratory potential. In summary, the combination of pentaisomaltose and 1-2 % DMSO improves the cryoprotective properties compared to 10 % DMSO while achieving comparable results with CS10 and even showing improved migration towards SDF-1α. Thus, our results show promising potential for pentaisomaltose in combination with low amounts of DMSO for the cryopreservation of T cells.
Step coverage simulation and measurement in a dc planar magnetron sputtering system (1983)

The step coverage of a dc planar magnetron sputtering system with a revolving substrate is analyzed by both computer simulation and measurement of the step coverage. The model assumes line of sight deposition, no reemission, and the cosine growth law. Good quantitative agreement has been obtained between the model and the experiments. The modeled system does not show the deep cracks typical of the point source planetary system. This is explained by comparing the vapor distribution functions of the planetary and the sputtering systems.
Rome III: The new criteria (2006)

The new Rome III criteria reflects upon a more than 15 year process to legitimize, classify and bring scientific credibility to the functional GI disorders. This has occurred through a series of activities and documents including the recently published Rome III book and a journal issue in Gastroenterology published in April, 2006. The work involved has involved committees of 87 international investigators from 17 countries, 2 of whom are from China. This article will review the Rome committee process that led to the production of these documents, the Rome III classification system, a description of the changes from Rome II (published in 2000) to Rome III and information on the future of Rome Foundation activities.