gebhart/patrepeval huggingface dataset:
Simulation of damage in a porcine prosthetic heart valve (1999)

A model of a bioprosthetic porcine valve has been produced which simulates the non-linear elastic behaviour of the fixed tissue and the re-inforcement of the leaflets by collagen fibre bundles. The loading on the model is a spatially uniform but temporally varying distribution of pressure. Bending is allowed in the tissue of the leaflets and is shown to be significant in determining the behaviour and failure modes of the leaflets. The simulation of the undamaged valve is validated against in vitro pulse duplicator studies and a simple fluid--solid interaction simulation. Progressive damage is introduced into three models of the valve at a location where tears have been commonly found in vivo. It was found that during the opening and closing of the valve the tip of the tears were subject to mode III or tearing displacements, but that in the fully closed or diastolic state the tear tip was subject to mode I or opening displacements such that it would be expected to propagate parallel to the line of attachment to the stent. The tear tip stresses increased with the length of the tear so that the rate of tearing would be expected to increase with length.
Lightly N/sub 2/O nitrided dielectrics grown in a conventional furnace for E/sup 2/PROM and 0.25 μm CMOS (2002)

For deep-submicron CMOS transistors and FLOTOX E/sup 2/PROM devices a considerable improvement in reliability and performance can be achieved when nitrided dielectrics are used. We developed an N/sup 2/O nitridation technology for a conventional furnace. Oxidation and nitridation are done in one run with a two-step and low-thermal budget processing to grow a dielectric layer with a thickness of 6-10 nm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prospects for developing a molecular cure for thalassemia (2005)

The delineation of the thalassemia syndromes started in the late 1950s with the distinction of alpha and beta thalassemias and the initial studies that pointed out to the considerable genetic heterogeneity of these disorders. Molecular investigations, however, had to wait for the development of recombinant DNA and molecular cloning techniques in the 1970s. The thalassemias were the first human disorders to be delineated at the DNA level and indeed, by the mid 1980s their molecular pathology had been determined. Investigators in this field always hoped that the molecular understanding of thalassemias would provide clues for the development of molecular therapies and perhaps cures. This hypothesis, however, was proven wrong; no clues for therapies have come from the molecular analysis of the large number of thalassemia mutations that have so far been characterized. Hopes for a molecular cure are now resting on the development of gene therapy. Special for beta thalassemia and the other beta chain hemoglobinopathies is a form of therapy that has been
Low-density lipoprotein for delivery of an acrylophenone antineoplastic molecule into malignant cells. (1992)

In vitro and in vivo data have indicated that tumor cells actively internalize the low-density lipoprotein (LDL) from the circulation. A family of 2-(aminomethyl) acrylophenones (AMA) possesses an in vitro antileukemic activity but is devoid of any in vivo antineoplastic activity, because the compounds are actively captured by proteins in solution in the blood. In order to achieve a selective delivery of these drugs via the LDL pathway, we have incorporated an AMA drug, 2-morpholinomethyl-2',3',4'- trimethoxy acrylophenone hydrochloride (ILE) into LDL particles. ILE spontaneously associated with LDL to produce an LDL-ILE complex containing 200 +/- 100 molecules of drug per LDL particle. The LDL-ILE complex was highly electronegative as detected by electrophoresis. Further, this complex presented an immunologically detected over expression of the ligand-binding domain to the LDL receptor. In spite of these modifications, the LDL receptor processing bound, internalized, and degraded the LDL-ILE complex. Nevertheless, these biological properties were reduced by 32, 20, and 40%, respectively, in comparison to native LDL. Despite its high electronegativity, the LDL-ILE complex was not recognized by the macrophagic scavenger receptor. The LDL-ILE complex showed specific LDL receptor mediated in vitro cytotoxicity as judged from the growth inhibition of neoplastic A549 cells and of normal fibroblasts, but no activity on defective LDL receptor cells. Further, the pharmacological activity of the complex against A549 cells has been demonstrated to be equally potent as that of the free drug (median inhibitory dose, 5 microM). It is suggested that LDL drug targeting of AMA molecules could specifically deliver active molecules to cancer cells, avoiding their entrapment by other blood proteins and their rapid clearance by the reticuloendothelial system.
Integrated CPU-GPU Power Management for 3D Mobile Games (2014)

Modern system-on-chips (SoC) integrate CPU and GPU for immersive 3D gaming experience. These games require both the CPU and GPU to work in tandem, resulting in high power consumption. In the past, Dynamic Voltage Frequency Scaling (DVFS) has been exploited for embedded CPU to save power during game play; but it is only recently that embedded GPUs have attained DVFS capabilities that provide additional opportunities. In this paper, we propose a power management approach that takes a unified view of the CPU-GPU DVFS, resulting in reduced power consumption for latest 3D mobile games compared to an independent CPU-GPU power management approach.
Mode selection in complex-coupled semiconductorDFB lasers (1995)

Mode suppression in complex-coupled DFB lasers with both in-phase and antiphase gain gratings is examined through a novel use of power balance. The theory is then backed up by more detailed arguments using a dynamic time domain model. The phase of the gain grating in relation to the index grating determines which mode of the DFB is suppressed. Longitudinal variations in the gain coupling coefficient caused by spatial hole burning provide additional side-mode suppression mechanisms.
Cooperative effects in water-biomolecule crystal systems. (1982)

Monte Carlo computer simulation techniques have been used to model non-pair-additive (cooperative) effects in the water organization around several biomolecules. Although most models for water assume pair-additive potentials, both quantum mechanical calculations and experimental data indicate that cooperative effects are not negligible in hydrogen-bounded systems such as water. The many-body polarizable electropole (PE) model for water is used to examine the extent and the consequences of this cooperative behavior in several biomolecule hydrate crystals. Increases in the dipole moments of water molecules are predicted in all systems studied so far and can be as much as 50% more than the monomer value of 1.855 debyes. The average value of the individual dipole moments for any one system differs from that of another system and, therefore, should be considered a property of the system and not of the water molecule itself. When this previously calculated average value of the dipole moment for water molecules in a given system is used as a fixed parameter in the simulation, we find differences between this fixed calculation and the original unfixed simulation. An alternative procedure, which allows for a spread in dipole moments and is not dependent on a predetermined average value, has been developed to make simulations of large water-protein systems, including cooperative effects, computationally feasible.
Retroviral nucleocapsid protein-metal ion interactions: folding and sequence variants. (1990)

Retroviral nucleocapsid proteins contain one or two proposed metal-binding sequences of the form Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys. Previously, we reported that an 18-amino acid peptide derived from the nucleocapsid protein of Rauscher murine leukemia virus (RMLV) binds metals such as Co2+ and Zn2+. We have now synthesized the entire nucleocapsid protein from RMLV. We report here that the protein also binds Co2+ and Zn2+ and does so with a higher affinity than does the peptide. Limited proteolysis and circular dichroism studies reveal that metal binding induces folding of the metal-binding domain and, perhaps, the regions adjacent to it but the remainder of the protein remains in a relatively unstructured state. In addition, we have synthesized sequence variants of the metal-binding domain that correspond to viral mutations reported in the literature. In many cases, the metal-binding properties of these peptides correlate with the observed biological activity, providing further evidence for the importance of metal binding to nucleocapsid function.
Evaluation of the Nasal Surgical Questionnaire for Monitoring Results of Septoplasty (2015)

Monitoring the results of surgery is important. The otorhinolaryngology department of our hospital currently uses preoperative and postoperative versions of the Nasal Surgical Questionnaire (NSQ) for continuous evaluation of nasal septoplasty. In this study, 55 patients undergoing septoplasty answered the preoperative version twice to assess the NSQ's test-retest precision, and 75 patients answered the preoperative questionnaire before and the postoperative one 6 months after surgery to evaluate the NSQ's ability to detect change in symptoms following surgery. Both the pre- and postoperative versions of the NSQ use separate visual analogue scales (VAS) to assess nasal obstruction during the day, at night, and during exercise. Other nasal symptoms are graded as secondary outcomes using 4-point Likert scales. The mean VAS scores for the two preoperative obstruction ratings were not significantly different. The scores were significantly higher than in a normal population. There were also significant differences between preoperative and postoperative ratings. The mean pre- and postoperative scores at night for those who reported complete improvement were 66.1 and 8.4, substantial improvement 74.5 and 24.2, and no improvement 83.3 and 76.4. The NSQ reliably assesses nasal symptoms in patients and may be useful for both short and long term prospective studies of septoplasty.
A Novel T Cell-Engaging Bispecific Antibody for Treating Mesothelin-Positive Solid Tumors (2020)

As mesothelin is overexpressed in various types of cancer, it is an attractive target for therapeutic antibodies. T-cell bispecific antibodies bind to target cells and engage T cells via binding to CD3, resulting in target cell killing by T-cell activation. However, the affinity of the CD3-binding arm may influence CD3-mediated plasma clearance or antibody trapping in T-cell-containing tissues. This may then affect the biodistribution of bispecific antibodies. In this study, we used scFab and knob-into-hole technologies to construct novel IgG-based 1 + 1 MG1122-A and 2 + 1 MG1122-B bispecific antibodies against mesothelin and CD3ε. MG1122-B was designed to be bivalent to mesothelin and monovalent to CD3ε, using a 2 + 1 head-to-tail format. Activities of the two antibodies were evaluated in mesothelin-positive tumor cells in vitro and xenograft models in vivo. Although both antibodies exhibited target cell killing efficacy and produced regression of xenograft tumors with CD8+ T-cell infiltration, the antitumor efficacy of MG1122-B was significantly higher. MG1122-B may improve tumor targeting because of its bivalency for tumor antigen. It may also reduce systemic toxicity by limiting the activation of circulating T cells. Thus, MG1122-B may be useful for treating mesothelin-positive solid tumors.
Interface to Network Security Functions (I2NSF) Problem Statement (2015)

This document describes the motivation and the problem statement for
Interface to Network Security Functions (I2NSF).
Cochlear Implant Fixation Using Resorbable Mesh (2011)

In this article we describe a new method of cochlear implant receiver-stimulator fixation using a resorbable poly (D,L) lactic acid mesh. We conducted a retrospective case review at a tertiary referral center; 10 pediatric and 4 adult patients had undergone cochlear implantation during the period from February to October 2008. Resorbable poly (D,L) lactic acid mesh and pins were used for fixation of the cochlear implant receiver stimulator. The receiver stimulator was assessed for stability/migration, and the scalp flap/incision were evaluated for allergic reactions, infections, and healing problems. With an average follow-up of 17.2 months, no patients had migration of the receiver stimulator, and there was no evidence of infection, wound dehiscence, or allergic reaction. Early results indicate that fixation of a cochlear implant receiver stimulator using resorbable mesh is well tolerated and provides good stability without device migration. Resorbable mesh fixation of the receiver stimulator is a reasonable alternative technique for cochlear implantation.
Liquid–Liquid Extraction of 3FOx and 5FOx Polyoxetane Diols: Impact on Polyurethane Mechanical Properties, Surface Morphology, and Wetting Behavior (2012)

Abstract Laboratory prepared and commercial poly(2‐2,2,2‐trifluoroethoxy‐2‐methyl)oxetane, P[3FOx] and poly(2‐2,2,2‐pentafluoropropoxy‐2‐methyl)oxetane, P[5FOx] polyols contain varying amounts of cyclics and low molar mass (LMW) constituents as byproducts of ring opening polymerization. Guided by phase diagrams determined by cloud point measurements, P[3FOx] diol separation is achieved. The impact of purification is explored via the preparation of P[3FOx] and P[5FOx] polyurethanes from cyclic/LMW‐free diols. Mechanical properties are improved because of higher polyurethane molecular weights. AFM revealed complex rugosity that is correlated with dynamic contact angles free from effects of water contamination.
Removing Spatial Variation from Wheat Yield Trials: A Comparison of Methods (1994)

Most cultivar evaluation trials use blocked designs and are analyzed using classical analysis of variance; however, a standard analysis for blocked designs often does not adequately account for spatial variability. Recent advances in spatial statistics suggest that there are better alternatives. The primary objective of this research was to compare randomized complete block (RCB) analysis with two nearest neighbor adjustment (NNA) methods; a random field procedure was also examined, as another way to remove spatial variability. Yield data from three replicated breeding nurseries involving diverse adapted and unadapted germplasm, each grown at four locations in Nebraska during 1988–1989, were used for the comparisons. The NNA approach was superior for all nurseries at all locations, on the basis of lower coefficient of variation and greater ability to distinguish cultivar differences. For 9 of 12 trials, RCB cultivar means were highly correlated with NNA cultivar means, indicating that both procedures would identify similar elite lines. For three trials, however, the estimated cultivar yield and cultivar rank from RCB and NNA procedures were different, and so different lines would be selected. The random field analysis was applied to the trial for which the discrepancy between the RCB and NNA analysis was greatest; this yielded results similar to the nearest neighbor analysis. Our results suggest that spatial trends are common in Nebraska and compromise the accuracy and precision of standard analysis of blocked designs. Therefore, NNA or random field analysis should be used to improve the analysis of breeding trials.
Chemical Composition of Selected Edible Nut Seeds (2006)

Commercially important edible nut seeds were analyzed for chemical composition and moisture sorption. Moisture (1.47-9.51%), protein (7.50-21.56%), lipid (42.88-66.71%), ash (1.16-3.28%), total soluble sugars (0.55-3.96%), tannins (0.01-0.88%), and phytate (0.15-0.35%) contents varied considerably. Regardless of the seed type, lipids were mainly composed of mono- and polyunsaturated fatty acids (>75% of the total lipids). Fatty acid composition analysis indicated that oleic acid (C18:1) was the main constituent of monounsaturated lipids in all seed samples. With the exception of macadamia, linoleic acid (C18:2) was the major polyunsaturated fatty acid. In the case of walnuts, in addition to linoleic acid (59.79%) linolenic acid (C18:3) also significantly contributed toward the total polyunsaturated lipids. Amino acid composition analyses indicated lysine (Brazil nut, cashew nut, hazelnut, pine nut, and walnut), sulfur amino acids methionine and cysteine (almond), tryptophan (macadamia, pecan), and threonine (peanut) to be the first limiting amino acid as compared to human (2-5 year old) amino acid requirements. The amino acid composition of the seeds was characterized by the dominance of hydrophobic (range = 37.16-44.54%) and acidic (27.95-33.17%) amino acids followed by basic (16.16-21.17%) and hydrophilic (8.48-11.74%) amino acids. Trypsin inhibitory activity, hemagglutinating activity, and proteolytic activity were not detected in the nut seed samples analyzed. Sorption isotherms (Aw range = 0.08-0.97) indicated a narrow range for monolayer water content (11-29 mg/g of dry matter). No visible mold growth was evident on any of the samples stored at Aw < 0.53 and 25 degrees C for 6 months.
Intestine-specific deletion of metal transporter <i>Zip14 (Slc39a14)</i> causes brain manganese overload and locomotor defects of manganism (2020)

Impaired manganese (Mn) homeostasis can result in excess Mn accumulation in specific brain regions and neuropathology. Maintaining Mn homeostasis and detoxification is dependent on effective Mn elimination. Specific metal transporters control Mn homeostasis. Human carriers of mutations in the metal transporter ZIP14 and whole body <i>Zip14</i>-knockout (WB-KO) mice display similar phenotypes, including spontaneous systemic and brain Mn overload and motor dysfunction. Initially, it was believed that Mn accumulation due to <i>ZIP14</i> mutations was caused by impaired hepatobiliary Mn elimination. However, liver-specific <i>Zip14</i>-KO mice did not show systemic Mn accumulation or motor deficits. ZIP14 is highly expressed in the small intestine and is localized to the basolateral surface of enterocytes. Thus, we hypothesized that basolaterally localized ZIP14 in enterocytes provides another route for the elimination of Mn. Using wild-type and intestine-specific <i>Zip14</i>-KO (I-KO) mice, we have shown that ablation of intestinal <i>Zip14</i> is sufficient to cause systemic and brain Mn accumulation. The lack of intestinal ZIP14-mediated Mn excretion was compensated for by the hepatobiliary system; however, it was not sufficient to maintain Mn homeostasis. When supplemented with extra dietary Mn, I-KO mice displayed some motor dysfunctions and brain Mn accumulation based on both MRI imaging and chemical analysis, thus demonstrating the importance of intestinal ZIP14 as a route of Mn excretion. A defect in intestinal <i>Zip14</i> expresssion likely could contribute to the Parkinson-like Mn accumulation of manganism.<b>NEW & NOTEWORTHY</b> Mn-induced parkinsonism is recognized as rising in frequency because of both environmental factors and genetic vulnerability; yet currently, there is no cure. We provide evidence in an integrative animal model that basolaterally localized ZIP14 regulates Mn excretion and detoxification and that deletion of intestinal ZIP14 leads to systemic and brain Mn accumulation, providing robust evidence for the indispensable role of intestinal ZIP14 in Mn excretion.
Electron transport at metal-semiconductor interfaces: General theory (1992)

A dipole-layer approach is presented, which leads to analytic solutions to the potential and the electronic transport at metal-semiconductor interfaces with arbitrary Schottky-barrier-height profiles. The presence of inhomogeneities in the Schottky-barrier height is shown to lead to a coherent explanation of many anomalies in the experimental results. These results suggest that the formation mechanism of the Schottky barrier is locally nonuniform at common, polycrystalline, metal-semiconductor interfaces.
Avaliação do atrito em braquetes autoligáveis submetidos à mecânica de deslizamento: um estudo in vitro (2011)

INTRODUÇÃO: o atrito gerado na interface braquete/fio durante a mecânica de deslizamento pode reduzir a eficiência da movimentação ortodôntica. O método de ligação do fio ao braquete exerce importante papel na determinação desse atrito. MÉTODOS: o presente estudo comparou a força de atrito gerada por quatro tipos de braquetes autoligáveis (Time®; Damon 2®; In-Ovation R® e Smart Clip®) com um grupo de braquetes ortodônticos convencionais (Dynalock®) associados a ligaduras elásticas tradicionais (Dispens-A-Stix®), que serviu como grupo controle. A força de atrito estático foi mensurada através da máquina universal de ensaios EMIC® DL 500 com dois fios de aço inoxidável com secção transversal 0,018" e 0,017" x 0,025". RESULTADOS: a análise de variância ANOVA e o teste de Tukey mostraram baixos níveis de atrito nos quatro braquetes autoligáveis associados ao fio 0,018" (P<0,05). Entretanto, os resultados observados quando os braquetes autoligáveis foram testados com fios 0,017" x 0,025" mostraram alta resistência ao deslizamento nos grupos de braquetes autoligáveis ativos.
Word embeddings quantify 100 years of gender and ethnic stereotypes (2018)

Word embeddings are a powerful machine-learning framework that represents each English word by a vector. The geometric relationship between these vectors captures meaningful semantic relationships between the corresponding words. In this paper, we develop a framework to demonstrate how the temporal dynamics of the embedding helps to quantify changes in stereotypes and attitudes toward women and ethnic minorities in the 20th and 21st centuries in the United States. We integrate word embeddings trained on 100 y of text data with the US Census to show that changes in the embedding track closely with demographic and occupation shifts over time. The embedding captures societal shifts-e.g., the women's movement in the 1960s and Asian immigration into the United States-and also illuminates how specific adjectives and occupations became more closely associated with certain populations over time. Our framework for temporal analysis of word embedding opens up a fruitful intersection between machine learning and quantitative social science.
PMU measurements application for transmission line temperature and sag estimation algorithm development (2014)

This paper gives an insight in synchrophasor technologies and proposes an overall framework for estimating power transmission line parameters, by employing synchronous phasors in real time. Based on estimated line parameters, the average line temperature and the sag of selected spans can be calculated and utilized for dynamic thermal rating applications for increased power transfer.