gebhart/patrepeval huggingface dataset:
Nanomagnetism of Magnetoelectric Granular Thin-Film Antiferromagnets (2019)

Antiferromagnets have recently emerged as attractive platforms for spintronics applications, offering fundamentally new functionalities compared with their ferromagnetic counterparts. Whereas nanoscale thin-film materials are key to the development of future antiferromagnetic spintronic technologies, existing experimental tools tend to suffer from low resolution or expensive and complex equipment requirements. We offer a simple, high-resolution alternative by addressing the ubiquitous surface magnetization of magnetoelectric antiferromagnets in a granular thin-film sample on the nanoscale using single-spin magnetometry in combination with spin-sensitive transport experiments. Specifically, we quantitatively image the evolution of individual nanoscale antiferromagnetic domains in 200 nm thin films of Cr<sub>2</sub>O<sub>3</sub> in real space and across the paramagnet-to-antiferromagnet phase transition, finding an average domain size of 230 nm, several times larger than the average grain size in the film. These experiments allow us to discern key properties of the Cr<sub>2</sub>O<sub>3</sub> thin film, including the boundary magnetic moment density, the variation of critical temperature throughout the film, the mechanism of domain formation, and the strength of exchange coupling between individual grains comprising the film. Our work offers novel insights into the magnetic ordering mechanism of Cr<sub>2</sub>O<sub>3</sub> and firmly establishes single-spin magnetometry as a versatile and widely applicable tool for addressing antiferromagnetic thin films on the nanoscale.
Objective estimation of the listening effort: Towards a neuropsychological and neurophysical model (2008)

Modern hearing aid fitting could be revolutionized by the availability of objective methods for the listening effort estimation. However experimental and theoretical research dealing with this subject is still in its infancy. In this paper we present first results towards a neuropsychological and neurophysical model for the objective estimation of the listening effort by electroencephalographic data. Our model is based on intended endogenously driven top-down projections represented by corticothalamic feedback dynamics for auditory stream selection and their large-scale correlates in auditory evoked late responses. The predictions of the presented model are compared to experimental data obtained during different auditory tasks which required a graduated effort for their solutions. The experimental data verified the model predictions.It is concluded that the proposed neuropsychological and neurophysical modeling of stream selection provides an appropriate framework for listening effort estimation. The presented preliminary results of an ongoing study are encouraging,however, further focal research is necessary in order to estimate in how far the presented model and future extensions might support modern hearing aid fitting in practice.
The Quality of Advertising Education Today (1973)

Abstract Based upon their findings in a survey of advertising educators. practitioners, and students, the authors cite a lack of agreement on the proper content, the value, and the aims of advertising education. The article suggests that this failure to achieve consensus is actually a failure of communication, which is further manifested in the fact that educators have achieved neither the respect of nor the leadership in the field. The authors maintain that educators have the potential to command both but that they themselves must correct the situation through meaningful interaction win practitioners and thus resolve these misunderstandings and make their rightful contribution to advertising. Note: The authors wish to thank Davenport Bruker, graduate student at the Universiy of Georgia, for his valued assistance in conducting the survey used in this study.
High Resolution Crystal Structures of Siglec-7 (2003)

Sialic acid-binding immunoglobulin-like lectins (Siglecs) recognize sialylated glycoconjugates and play a role in cell-cell recognition. Siglec-7 is expressed on natural killer cells and displays unique ligand binding properties different from other members of the Siglec family. Here we describe the high resolution structures of the N-terminal V-set Ig-like domain of Siglec-7 in two crystal forms, at 1.75 and 1.9 A. The latter crystal form reveals the full structure of this domain and allows us to speculate on the differential ligand binding properties displayed by members of the Siglec family. A fully ordered N-linked glycan is observed, tethered by tight interactions with symmetry-related protein molecules in the crystal. Comparison of the structure with that of sialoadhesin and a model of Siglec-9 shows that the unique preference of Siglec-7 for alpha(2,8)-linked disialic acid is likely to reside in the C-C' loop, which is variable in the Siglec family. In the Siglec-7 structure, the ligand-binding pocket is occupied by a loop of a symmetry-related molecule, mimicking the interactions with sialic acid.
Cyclosporin a modulation of tumor necrosis factor gene expression and effects in vitro and in vivo. (1990)

We investigated, in vitro and in vivo, the cyclosporin A (CsA) regulation of LPS-induced TNF gene expression and subsequent pathophysiologic changes. In vitro dose-response kinetics data showed that CsA inhibited TNF bioactivity in the supernatant without delaying its production, whereas Northern blot and in situ hybridization analysis demonstrated that CsA did not inhibit TNF mRNA expression. We then sought to examine the in vivo effects of CsA (75 mg/kg) in CBA/J mice that were primed with CFA, and injected 2 wk later with LPS. CsA demonstrated suppression of local levels (ascites) of TNF as measured by either bioactivity or an anti-murine TNF ELISA. However, CsA did not decrease mRNA for TNF, or cell-associated TNF. In vivo kinetics studies were performed to show that CsA blocked both local (ascites) and systemic (plasma) LPS-induced TNF production without delaying these effects. CsA inhibited the neutrophilia and lymphopenia that developed after the LPS challenge, but did not block the lung neutrophilic infiltrate. These observations are helpful in understanding the role of the macrophage in CsA immunosuppression, particularly with regard to the ability of CsA to block LPS-induced TNF secretion.
Shc Phosphotyrosine-Binding Domain Dominantly Interacts with Epidermal Growth Factor Receptors and Mediates Ras Activation in Intact Cells (1998)

The adaptor protein Shc contains a phosphotyrosine binding (PTB) domain and a Src homology 2 (SH2) domain, both of which are known to interact with phosphorylated tyrosines. We have shown previously that tyrosine 1148 of the activated epidermal growth factor (EGF) receptor is a major binding site for Shc while tyrosine 1173 is a secondary binding site in intact cells. In the present study, we investigated the interaction between the PTB and SH2 domains of Shc and the activated human EGF receptor. Mutant 52-kDa Shc with an arginine-to-lysine substitution at residue 175 in the PTB domain (Shc R175K) or 397 in the SH2 domain (Shc R397K) was coexpressed in Chinese hamster ovary cells overexpressing the wild-type or mutant EGF receptors that retained only one of the autophosphorylation sites at tyrosine 1148 (QM1148) or 1173 (QM1173). Shc R397K was coprecipitated with the QM1148 and QM1173 receptors, was tyrosine-phosphorylated, and associated with Grb2 and Sos. In contrast, coprecipitation of Shc R175K with the mutant receptors was barely detectable. In cells expressing the QM1173 receptor, Shc R175K was tyrosine-phosphorylated and associated with Grb2, while association of Sos was barely detectable. In cells expressing the QM1148 receptor, tyrosine phosphorylation of Shc R175K was markedly reduced. When both Shc R175K and 46-kDa Shc R397K were coexpressed with the mutant receptors, p46 Shc R397K was dominantly tyrosine-phosphorylated. In cells expressing the wild-type receptor, Shc R397K, but not Shc R175K, translocated to the membrane in an EGF-dependent manner. In addition, Ras activity stimulated by the immunoprecipitates of Shc R397K was significantly higher than that by the immunoprecipitates of Shc R175K. The present results indicate that tyrosine 1148 of the activated EGF receptor mainly interacts with the Shc PTB domain in intact cells. Tyrosine 1173 interacts with both the PTB and SH2 domains, although the interaction with the PTB domain is dominant. In addition, Shc bound to the activated EGF receptor via the PTB domain dominantly interacts with Grb2-Sos complex and plays a major role in the Ras-signaling pathway.
Denitrification Activities of Mo-V-Ti Catalysts Prepared by Dipping Method at Low Temperature (2018)

Mo-V-Ti catalysts of low temperature denitrification were prepared by dipping method. In order to study the activity of selective catalytic reduction, the catalyst was placed in a fixed bed reactor. Industrial flue gas was simulated with cylinder gas. The experimental condition is NO: 500ppm, NH 3 :500ppm, O 2 :8%, SO 2 :100ppm, N 2 : equilibrium gas, space velocity: 36000h -1 . Results indicate that the catalyst prepared by dipping method had good denitrification activity and sulfur resistance at low temperature. The optimum ratio of catalyst was 3V 2 O 5 -6MoO 3 -91TiO 2 (wt %). The conversion efficiency of NO was 80~93%, and the conversion efficiency of SO 2 was less than 1% at 180~260 °C.
High-Density Lipoproteins as an Emerging Therapeutic Target for Atherosclerosis (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Numerical modeling of electromagnetic coupling electronic device with proximity-based radio power control for LTE/WWAN SAR (2012)

In this paper, handheld hardware and utility design point view should be considering Radio power control for SAR problems. The authors use proximity sensor to detect when portable and electronic device is in close proximity to a human body. Tablets have higher radiation for users than laptops since antenna is closer to user. The authors use IR (light), temperature and capacitor combo type of proximity sensor with RF power control utility to adjust radio frequency signal transmit power levels.
Membrane condenser as emerging technology for water recovery and gas pre-treatment: current status and perspectives (2019)

Abstract The recent roadmap of SPIRE initiative includes the development of “new separation, extraction and pre-treatment technologies” as one of the “key actions” for boosting sustainability, enhancing the availability and quality of existing resources. Membrane condenser is an innovative technology that was recently investigated for the recovery of water vapor for waste gaseous streams, such as flue gas, biogas, cooling tower plumes, etc. Recently, it has been also proposed as pre-treatment unit for the reduction and control of contaminants in waste gaseous streams (SO x and NO x , VOCs, H 2 S, NH 3 , siloxanes, halides, particulates, organic pollutants). This perspective article reports recent progresses in the applications of the membrane condenser in the treatment of various gaseous streams for water recovery and contaminant control. After an overview of the operating principle, the membranes used, and the main results achieved, the work also proposes the role of this technology as pre-treatment stage to other separation technologies. The potentialities of the technology are also discussed aspiring to pave the way towards the development of an innovative technology where membrane condenser can cover a key role in redesigning the whole upgrading process.
Taxol-induced flexibility of microtubules and its reversal by MAP-2 and Tau. (1993)

When microtubules, ordinarily quite rigid structures, are treated in vitro with the anti-tumor drug taxol, they rapidly develop a wavy appearance and become strikingly flexible. A quantitative measure of their flexibility, the reciprocal statistical length, lambda, increases by an order of magnitude when taxol is bound. Subsequent addition of either of the microtubule-associated proteins MAP-2 or tau causes the flexibility to disappear. It can be restored again by removing the microtubule-associated protein. These results show that taxol changes microtubular structure substantially, probably by weakening the interactions between protofilaments, and that microtubule-associated proteins reverse these effects, possibly by bridging protofilaments. This structural change and the accompanying flexibility may contribute importantly to taxol's cytotoxic activity.
Integration of microelectronic chips in microfluidic systems on printed circuit board (2012)

A new scheme for the integration of small semiconductor transducer chips with microfluidic structures on printed circuit board (PCB) is presented. The proposed approach is based on a packaging technique that yields a large and flat area with small and shallow (∼44 µm deep) openings over the chips. The photocurable encapsulant material used, based on a diacrylate bisphenol A polymer, enables irreversible bonding of polydimethylsiloxane microfluidic structures at moderate temperatures (80 °C). This integration scheme enables the insertion of transducer chips in microfluidic systems with a lower added volume than previous schemes. Leakage tests have shown that the bonded structures withstand more than 360 kPa of pressure. A prototype microfluidic system with two detection chips, including one inter-digitated electrode (IDE) chip for conductivity and one ion selective field effect transistor (ISFET) chip for pH, has been implemented and characterized. Good electrical insulation of the chip contacts and silicon edge surfaces from the solution in the microchannels has been achieved. This integration procedure opens the door to the low-cost fabrication of complex analytical microsystems that combine the extraordinary potential of both the microfluidics and silicon microtechnology fields.
Deep ECGNet: An Optimal Deep Learning Framework for Monitoring Mental Stress Using Ultra Short-Term ECG Signals (2018)

We proposed an optimal deep learning architecture and its parameters for stress recognition, and the theoretical consideration on how to design the deep learning structure based on the periodic patterns of the raw ECG data. Experimental results in this study have proved that the proposed deep learning model, the Deep ECGNet, is an optimal structure to recognize the stress conditions using ultra short-term ECG data.
Kerr-microresonator solitons for accurate carrier-envelope-frequency stabilization (2017)

Carrier-envelope phase stabilization of optical pulses enables exquisitely precise measurements by way of direct optical-frequency synthesis, absolute optical-to-microwave phase conversion, and control of ultrafast waveforms. We report such phase stabilization for Kerr-microresonator frequency combs integrated on silicon chips, and verify their fractional-frequency inaccuracy at <3x10-16. Our work introduces an interlocked Kerr-comb configuration comprised of one silicon-nitride and one silica microresonator, which feature nearly harmonic repetition frequencies and can be generated with one laser. These frequency combs support an ultrafast-laser regime with few-optical-cycle, 1-picosecond-period soliton pulses and a total dispersive-wave-enhanced bandwidth of 170 THz, while providing a stable phase-link between the optical and microwave domains. To accommodate low-power and mobile application platforms, our phase-locked frequency-comb system operates with <250 mW of chip-coupled power. Our work establishes Kerr-microresonator combs as a viable technology for applications like optical-atomic timekeeping, optical synthesis, and related directions.
Localization of the Lectin, ERp57 Binding, and Polypeptide Binding Sites of Calnexin and Calreticulin (2002)

Calnexin and calreticulin are membrane-bound and soluble chaperones, respectively, of the endoplasmic reticulum (ER) which interact transiently with a broad spectrum of newly synthesized glycoproteins. In addition to sharing substantial sequence identity, both calnexin and calreticulin bind to monoglucosylated oligosaccharides of the form Glc(1)Man(5-9)GlcNAc(2), interact with the thiol oxidoreductase, ERp57, and are capable of acting as chaperones in vitro to suppress the aggregation of non-native proteins. To understand how these diverse functions are coordinated, we have localized the lectin, ERp57 binding, and polypeptide binding sites of calnexin and calreticulin. Recent structural studies suggest that both proteins consist of a globular domain and an extended arm domain comprised of two sequence motifs repeated in tandem. Our results indicate that the primary lectin site of calnexin and calreticulin resides within the globular domain, but the results also point to a much weaker secondary site within the arm domain which lacks specificity for monoglucosylated oligosaccharides. For both proteins, a site of interaction with ERp57 is centered on the arm domain, which retains approximately 50% of binding compared with full-length controls. This site is in addition to a Zn(2+)-dependent site located within the globular domain of both proteins. Finally, calnexin and calreticulin suppress the aggregation of unfolded proteins via a polypeptide binding site located within their globular domains but require the arm domain for full chaperone function. These findings are integrated into a model that describes the interaction of glycoprotein folding intermediates with calnexin and calreticulin.
Optimization in organic synthesis. An approach to obtaining kinetic information by sequential response surface modelling. Outline of the principles (1993)

Abstract A method is presented by which it is possible to estimate the initial rate of chemical reactions when the experimental conditions are varied according to a response surface design. The method is intended as a complementary method for analysing data obtained from experiments in synthetic chemistry when the objective is to optimize the yield of the reaction. Data obtained by simulations have been used to develop the method. From the simulated reactions it is shown that sequential analysis of the chemical yield of the reaction makes it possible to estimate models which describe how the parameters of the response surface of the yield vary over time. The derivatives of these time functions of the response surface parameters can be used to define a rate function which describes how the variations in the experimental conditions influence the rate of the reaction. It is shown how such rate functions can be used to afford reasonable estimates of the initial rates of the reaction. The initial reaction rates thus estimated can be used to determine the kinetic order of the reactants and also to provide estimates of the activation energy of the reaction. A thorough discussion of how canonical analysis of the rate function may assist in the elucidation of reaction mechanisms is given.
On Multivariate Goodness-of-Fit and Two-Sample Testing (2004)

It is shown how classification learning machines can be used to do multivariate goodness-of-fit and two-sample testing.
Effects of face masks on acoustic analysis and speech perception: Implications for peri-pandemic protocols (2020)

Wearing face masks (alongside physical distancing) provides some protection against infection from COVID-19. Face masks can also change how people communicate and subsequently affect speech signal quality. This study investigated how three common face mask types (N95, surgical, and cloth) affected acoustic analysis of speech and perceived intelligibility in healthy subjects. Acoustic measures of timing, frequency, perturbation, and power spectral density were measured. Speech intelligibility and word and sentence accuracy were also examined using the Assessment of Intelligibility of Dysarthric Speech. Mask type impacted the power distribution in frequencies above 3 kHz for the N95 mask, and above 5 kHz in surgical and cloth masks. Measures of timing and spectral tilt mainly differed with N95 mask use. Cepstral and harmonics to noise ratios remained unchanged across mask type. No differences were observed across conditions for word or sentence intelligibility measures; however, accuracy of word and sentence translations were affected by all masks. Data presented in this study show that face masks change the speech signal, but some specific acoustic features remain largely unaffected (e.g., measures of voice quality) irrespective of mask type. Outcomes have bearing on how future speech studies are run when personal protective equipment is worn.
<scp>IL</scp>‐33/<scp>ST</scp>2 signalling contributes to carrageenin‐induced innate inflammation and inflammatory pain: role of cytokines, endothelin‐1 and prostaglandin <scp>E</scp><sub>2</sub> (2013)

IL-33/ST2 signalling triggers the production of inflammatory mediators contributing to carrageenin-induced inflammation. These data reinforces the importance of IL-33/ST2 signalling as a target in innate inflammation and inflammatory pain.
Vibration Error Correction for the FOGs-Based Measurement in a Drilling System Using an Extended Kalman Filter (2021)

Fiber-optic gyroscopes (FOGs)-based Measurement While Drilling system (MWD) is a newly developed instrument to survey the borehole trajectory continuously and in real time. However, because of the strong vibration while drilling, the measurement accuracy of FOG-based MWD deteriorates. It is urgent to improve the measurement accuracy while drilling. Therefore, this paper proposes an innovative scheme for the vibration error of the FOG-based MWD. Firstly, the nonlinear error models for the FOGs and ACCs are established. Secondly, a 36-order Extended Kalman Filter (EKF) combined with a calibration method based on 24-position is designed to identify the coefficients in the error model. Moreover, in order to obtain a higher accurate error model, an iterative calibration method has been suggested to suppress calibration residuals. Finally, vibration experiments simulating the drilling vibration in the laboratory is implemented. Compared to the original data, compensated the linear error items, the error of 3D borehole trajectory can only be reduced by a ratio from 10% to 34%. While compensating for the nonlinear error items of the FOG-based MWD, the error of 3D borehole trajectory can be reduced by a ratio from 44.13% to 97.22%. In conclusion, compensation of the nonlinear error of FOG-based MWD could improve the trajectory survey accuracy under vibration.
Serum ghrelin levels in patients with Behcet’s disease (2016)

Ghrelin levels were lower in BD patients compared to healthy controls. There was no association between reduced ghrelin levels and MetS; however, there was a negative correlation between ghrelin levels and disease activity.