gebhart/patrepeval huggingface dataset:
I/Q channel reversal correcting properties of an SQPSK Costas loop with integrated symbol synchronization (1988)

An integrated-carrier loop/symbol synchronizer, using a digital Costas loop with matched arm filters to demodulate staggered quaternary phase-shift keyed (QPSK) signals, is analyzed. An expression is derived for the S curve, parameterized by bit synchronization error. This result suggests that the demodulator structure offers an inherent I/Q channel reversal correcting capability. Computer simulation results are presented that support this conclusion, and suggest that ambiguity resolution performance depends on the ratio of carrier and synchronization loop bandwidths.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Flexor Tendon Injuries: II. Operative Technique (1995)

The repair of flexor tendons (zones I and II) is a technique-intensive surgical undertaking. It requires a strong understanding of the anatomy of the tendon sheath and the normal relationship between the pulleys and the flexor digitorum superficialis and flexor digitorum profundus tendons in the digit. Meticulous exposure, careful tendon retrieval, and atraumatic repair are extremely important, and the repair should be of sufficient strength to resist gapping and permit the early postrepair application of motion forces. Whenever possible, the tendon sheath should be preserved or repaired, and a smooth gliding surface should be reestablished. The author describes an effective method of tendon retrieval and a simplified technique for a four-strand tendon repair with a supplementary peripheral running-lock suture. The repair is considered to maintain sufficient strength throughout healing to allow a postrepair rehabilitation protocol that will impart passive and modest active stress forces to the repaired tendons. Complications include tendon rupture, digital joint flexion contractures, and adhesions that restrict tendon gliding and ultimately necessitate tenolysis.
Characterization of Anionic Peroxidases in Tomato Isolines Infected by Meloidogyne incognita. (1993)

Changes in peroxidase activity during nematode infection were studied using root extracts of tomato near-isogenic lines differing in resistance to Meloidogyne incognita. Total peroxidase activity increased slightly in crude extracts of four susceptible isolines but doubled in two resistant lines, Monita and Motaci. Nematode infection enhanced levels of both p-phenylenediamine-pyrocatechol oxidase and syringaldazine oxidase 7 days after inoculation, especially in resistant lines. This elevated peroxidase activity in resistant isolines was caused by an increase in anionic peroxidase activity. These enzymes, which likely are involved in lignification, were isolated and purified from tomato isolines by ammonium sulfate precipitation, high performance ion-exchange chromatography, and gel electrophoresis. The purified anionic peroxidase extracts contained an electrophoretic band with Rf 0.51 that was present in extracts of infected but not uninfected roots.
(6R,6S)-5,8,10-Trideaza-5,6,7,8-tetrahydrofolate and (6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydropteroyl-L-ornithine as potential antifolates and antitumor agents. 35 (1989)

(6R,6S)-5,8,10-Trideaza-5,6,7,8-tetrahydropteroic acid was synthesized in several steps from 4,4-(ethylenedioxy)-cyclohexanone and [4-(tert-butyloxycarbonyl)benzyl]triphenylphosphonium bromide and was elaborated to (6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydropteroyl-L-glutamic acid and (6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydropteroyl-L-ornithin e. Compound 1 was found to be a good substrate for partially purified mouse liver folypolyglutamate synthetase (FPGS), with a Michaelis constant (Km = 15 microM) comparable to that reported for the reduced folate substrate (6S)-5,6,7,8-tetrahydropteroyl-L-glutamic acid and for (6R,6S)-5,10-dideaza-5,6,7,8-tetrahydropteroyl-L-glutamic acid (DDATHF). However, in striking contrast to DDATHF, which is potently cytotoxic, 1 failed to inhibit tumor cell growth in culture at concentrations of up to 100 microM. These results suggested that the NH at position 8 of DDATHF is important for cytotoxic activity but not for polyglutamylation. Just as 1 was a good substrate for FPGS, the ornithine analogue 2 proved to be among the more potent competitive inhibitors of this enzyme discovered to date, with a Ki,s of 10 microM. While the binding affinity of 2 was lower than that reported for 5,6,7,8-tetrahydropteroyl-L-ornithine (H4PteOrn), very substantial FPGS inhibition was observed even though N5,N8, and N10 in H4PteOrn were replaced by carbon. Binding to FPGS thus appears to be tolerant of bioisosteric replacements made simultaneously in ring B and the bridge region. Neither 1 nor 2 was active in preventing cell growth in culture at concentrations of up 100 microM. The N delta-hemiphthaloyl derivative of 2, synthesized as a potential prodrug, was also inactive.
Assessment of spectral analysis of heart rate variability in patients with history of atrial fibrillation by means of age-dependent parameters. (2002)

Heart rate variability evaluation is a useful diagnostic tool for autonomic nervous balance assessment. The role of the autonomic nervous system in aetiology of atrial fibrillation is sometimes clear as a trigger from a patient's history, but mostly it acts as a modulating factor which is not easy to detect. The present study demonstrates results of spectral analysis of short-term heart rate variability during ortho-clinostatic tests processed by means of age-dependent parameters. An original telemetric system and a unique method for heart rate variability assessment, developed by the Faculty of Physical Culture, were applied for the first time to examine patients with the history of atrial fibrillation.
Preparation of YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-δ</sub> Superconductor Coating on Austenitic Steel by Electrophoretic Deposition Method-Study on Buffering Layers (1992)

A preparation method of a superconducting oxides, YBa 2 Cu 3 O 7-δ , coating on austenitic stainless steel by electrophoretic deposition at high voltages has been investigated in order to increase the J c value. Without a buffering layer, Ni, Cr, and Fe atoms diffused from the substrate to the superconductor phase. It was found that ZrO 2 and Ag layers coated on the substrate as the buffering layer restrain the diffusion of the metals. Consequently, high density YBa 2 Cu 3 O 7-δ superconductor coating could be obtained at high voltage depositions, therefore, it indicated that high J c samples can be prepared by this method.
Highly Accurate Frequency Interpolation of Apodized FFT Magnitude-Mode Spectra (1998)

“Generalized” interpolation (called GIα here) of fast Fourier transform (FFT) spectra apodized by a family of sin α ( X) windows has previously been proposed. The GIα gives the highly accurate interpolated frequency by calculating the simple formula of frequency determination with the use of two squared ratios between three magnitudes nearest to the peak maximum on the apodized FFT spectrum. Although the value of window parameter α, limited to integer values, has been used for the GIα, we show in the present paper that the GIα with a real α value also gives an extremely good estimate of the true frequency from the sin α ( X)-apodized spectra. Thus, we intend to apply the GIα with the optimal values of α to FFT spectra apodized by any other window functions that are often used in Fourier spectroscopy. Simulation results show that the GIα is easier and more accurate than the KCe interpolation, which uses a family of interpolating functions [ KCe(ω) = ( aω 2 + bω + c) e ] proposed by Keefe and Comisarow. Finally, in the presence of noise we examine effects of damping and windowing on the frequency interpolation of FFT spectra. Because damping and windowing reduce the signal-to-noise ratio (SNR), we define anew the relative SNR by the ratio of the SNR of the apodized spectrum of a damped sinusoid to the SNR of the unapodized spectrum of an undamped sinusoid. Numerical calculation shows that the relative SNR varies, owing to damping rather than windowing. In fact, the observed frequency error roughly increases as the damping ratio increases for any window functions, as is expected from our previous investigation that the frequency error based upon the GIα is inversely proportional to the SNR. However, no obvious differences between the various window functions are observed in the presence of noise.
Photocurrent Enhancement from Diketopyrrolopyrrole Polymer Solar Cells through Alkyl-Chain Branching Point Manipulation (2013)

Systematically moving the alkyl-chain branching position away from the polymer backbone afforded two new thieno[3,2-b]thiophene-diketopyrrolopyrrole (DPPTT-T) polymers. When used as donor materials in polymer:fullerene solar cells, efficiencies exceeding 7% were achieved without the use of processing additives. The effect of the position of the alkyl-chain branching point on the thin-film morphology was investigated using X-ray scattering techniques and the effects on the photovoltaic and charge-transport properties were also studied. For both solar cell and transistor devices, moving the branching point further from the backbone was beneficial. This is the first time that this effect has been shown to improve solar cell performance. Strong evidence is presented for changes in microstructure across the series, which is most likely the cause for the photocurrent enhancement.
Okazaki Fragment Maturation in Yeast (2003)

In the presence of proliferating cell nuclear antigen, yeast DNA polymerase delta (Pol delta) replicated DNA at a rate of 40-60 nt/s. When downstream double-stranded DNA was encountered, Pol delta paused, but most replication complexes proceeded to carry out strand-displacement synthesis at a rate of 1.5 nt/s. In the presence of the flap endonuclease FEN1 (Rad27), the complex carried out nick translation (1.7 nt/s). The Dna2 nuclease/helicase alone did not efficiently promote nick translation, nor did it affect nick translation with FEN1. Maturation in the presence of DNA ligase was studied with various downstream primers. Downstream DNA primers, RNA primers, and small 5'-flaps were efficiently matured by Pol delta and FEN1, and Dna2 did not stimulate maturation. However, maturation of long 5'-flaps to which replication protein A can bind required both DNA2 and FEN1. The maturation kinetics were optimal with a slight molar excess over DNA of Pol delta, FEN1, and proliferating cell nuclear antigen. A large molar excess of DNA ligase substantially enhanced the rate of maturation and shortened the nick-translation patch (nucleotides excised past the RNA/DNA junction before ligation) to 4-6 nt from 8-12 nt with equimolar ligase. These results suggest that FEN1, but not DNA ligase, is a stable component of the maturation complex.
Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing (2020)

Despite frequent prescription of broad-spectrum empirical antimicrobials in patients with coronavirus-associated respiratory infections, there is a paucity of data to support the association with respiratory bacterial/fungal coinfection. Generation of prospective evidence to support development of antimicrobial policy and appropriate stewardship interventions specific for the COVID-19 pandemic is urgently required.
2-Deoxy-2-iodo-α-mannopyranosyl and -talopyranosyl Acetates:  Highly Stereoselective Glycosyl Donors for the Synthesis of 2-Deoxy-α-glycosides (1999)

[formula: see text] TMS-OTf- or TBS-OTf-promoted glycosidation reactions of 2-deoxy-2-iodo-alpha-mannopyranosyl acetates 8-10 and the 2-deoxy-2-iodo-alpha-talopyranosyl acetate 11 provide the corresponding 2-deoxy-2-iodo-alpha-pyranosides, precursors to 2-deoxy-alpha-glycosides, as the only observed reaction products.
Biological and Clinical Basis for Molecular Studies of Interferons (2005)

The cytokine family of interferons (IFNs) has multiple functions, including antiviral, anti-tumor, and immunomodulatory effects and regulation of cell differentiation. The multiple functions of the IFN system are thought to be an innate defense against microbes and foreign substances. The IFN system consists first of cells that produce IFNs in response to viral infection or other foreign stimuli and second of cells that establish the antiviral state in response to IFNs. This process of innate immunity involves multiple signaling mechanisms and activation of various host genes. Viruses have evolved to develop mechanisms that circumvent this system. IFNs have also been used clinically in the treatment of viral diseases. Improved treatments will be possible with better understanding of the IFN system and its interactions with viral factors. In addition, IFNs have direct and indirect effects on tumor cell proliferation, effector leukocytes and on apoptosis and have been used in the treatment of some cancers. Improved knowledge of how IFNs affect tumors and the mechanism that lead to a lack of response to IFNs would help the development of better IFN treatments for malignancies.
Biological characteristics of two lysines on human serum albumin in the high‐affinity binding of 4<i>Z</i>,15<i>Z</i>‐bilirubin‐IXα revealed by phage display (2011)

4Z,15Z-bilirubin-IXα (4Z,15Z-BR), an endogenous compound that is sparingly soluble in water, binds human serum albumin (HSA) with high affinity in a flexible manner. A phage library displaying recombinant HSA domain II was constructed, after three rounds of panning against immobilized 4Z,15Z-BR, and eight clones with high affinity for the pigment were found to contain conserved basic residues, such as lysine or arginine, at positions 195 and 199. The wild type and two mutants, K195A and K199A, of whole HSA as well as stand-alone domain II were expressed in Pichia pastoris for ligand-binding studies. The binding of 4Z,15Z-BR to the K195A and K199A mutants was decreased in both whole HSA and the domain II proteins. The P-helicity conformer (P-form) of 4Z,15Z-BR was found to preferentially bind to the wild types and the K195A mutants, whereas the M-form bound to the K199A mutants. Photoconversion experiments showed that the P-form of 4Z,15Z-BR was transformed into highly water-soluble isomers at a much faster rate than the M-form. In addition, the M-form of 4Z,15Z-BR showed higher affinity for domain I than for domain II. The present findings suggest that, whereas both Lys195 and Lys199 in subdomain IIA are important for the high-affinity binding of 4Z,15Z-BR, Lys199 plays a more prominent role in the elimination of 4Z,15Z-BR.
Personalized point-of-interest recommendation by mining users' preference transition (2013)

Location-based social networks (LBSNs) offer researchers rich data to study people's online activities and mobility patterns. One important application of such studies is to provide personalized point-of-interest (POI) recommendations to enhance user experience in LBSNs. Previous solutions directly predict users' preference on locations but fail to provide insights about users' preference transitions among locations. In this work, we propose a novel category-aware POI recommendation model, which exploits the transition patterns of users' preference over location categories to improve location recommendation accuracy. Our approach consists of two stages: (1) preference transition (over location categories) prediction, and (2) category-aware POI recommendation. Matrix factorization is employed to predict a user's preference transitions over categories and then her preference on locations in the corresponding categories. Real data based experiments demonstrate that our approach outperforms the state-of-the-art POI recommendation models by at least 39.75% in terms of recall.
Determination of Endogenous Acetylcholine Release in Freely Moving Rats by Transstriatal Dialysis Coupled to a Radioenzymatic Assay: Effect of Drugs (1987)

The technique of intracerebral dialysis in combination with a sensitive and specific radioenzymatic method was used for recovery and quantification of endogenous extracellular acetylcholine from the striata of freely moving rats. A thin dialysis tube was inserted transversally through the caudate nuclei, and the tube was perfused with Ringer solution, pH 6.1, at a constant rate of 2 microliter min-1. The perfusates were collected at 10-min intervals. In the presence of 1 and 10 microM physostigmine, acetylcholine release was 4.5 +/- 0.02 and 7.3 +/- 0.3 pmol/10 min, respectively (not corrected for recovery). The latter concentration of the acetylcholinesterase inhibitor was used in all experiments. Under basal conditions, acetylcholine output was stable over at least 4 h. A depolarizing K+ concentration produced a sharp, reversible 87% increase in acetylcholine output. Both the basal and K+-stimulated release were Ca2+ dependent. The choline uptake inhibitor hemicholinium-3 (20 micrograms intracerebroventricularly) reduced striatal acetylcholine output to 35% of the basal value within 90 min. Scopolamine (0.34 mg/kg s.c.) provoked a sharp enhancement of acetylcholine release of approximately 63% over basal values, whereas oxotremorine (0.53 mg/kg i.p.) transiently reduced acetylcholine release by 54%. These results indicate the physiological and pharmacological suitability of transstriatal dialysis for monitoring endogenous acetylcholine release.
Facile fabrication of graphene–polypyrrole–Mn composites as high-performance electrodes for capacitive deionization (2015)

Reduced graphene oxide–polypyrrole–MnO<sub>2</sub> composites are facilely prepared for high performance electrodes for capacitive deionization.
Effect of EGb761 on light-damaged retinal pigment epithelial cells. (2014)

Differences in some important proteins, such as cathepsin B, heat shock protein, and cytochrome c reductase, indicated that multiple pathways may be induced in light-damaged RPE cells and the protective effect of EGb761.
Thin Organosilicon Films for Integrated Optics (1972)

The continued development of integrated optics is heavily dependent upon the availability of materials that are suitable for the construction of thin-film optical circuitry and devices. We report here an investigation of new films made by an rf discharge polymerization process of organic chemical monomers. We concentrate our discussion on films prepared from vinyltrimethylsilane and hexamethyldisilbxane. These films are smooth, tough, pinhole-free, transparent from 0.4 microm to 0.75 microm, and exhibit very low loss (<0.04 dB/cm) for light-wave propagation. More importantly, experiments demonstrate the possibility of controlling the refractive index of the films either by the mixing of the two monomers before deposition or by chemical treatment after the film is deposited. The use of the prism-film coupler for studying the refractive index of each material is discussed in detail.
Self-complementary AAVs Induce More Potent Transgene Product-specific Immune Responses Compared to a Single-stranded Genome (2011)

Using a mouse model we show that self-complementary (sc) adeno-associated virus (AAV) vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene product-specific CD8(+) T cell and antibody responses compared to corresponding single-stranded (ss)AAV vectors. These data suggest that the higher and more rapidly appearing amounts of transgene product achieved with scAAV vectors may increase detrimental immune responses in gene transfer recipients.
ss-Lactam Antibiotic-Induced Release of Free Endotoxin: In Vitro Comparison of Penicillin-Binding Protein (PBP) 2-Specific Imipenem and PBP 3-Specific Ceftazidime (1992)

The relative effects of two beta-lactam antibiotics, penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime, upon in vitro induction of lipopolysaccharide (LPS) release were investigated against smooth- and rough-LPS mutant isolates of Pseudomonas aeruginosa. Free LPS liberated from both isolates are 10- to 40-fold higher for ceftazidime-exposed cultures than control or imipenem-treated cultures after 4-8 h at 35 degrees C despite equivalent MICs. Lethalities of filtrates in mice correlated with in vitro endotoxin assay results. Sub-MIC levels of ceftazidime induced filamentation and LPS release without significant bacterial lysis. Amounts released not only matched the quantities achieved at inhibitory concentrations (e.g., 1-, 2-, and 50-times MIC) of ceftazidime but significantly exceeded levels of LPS liberated by exposure to imipenem, less than or equal to 100 times its MIC. Sub-MIC levels of imipenem released relatively small amounts of free LPS while reducing colony counts approximately 2 logs more than equivalent amounts of ceftazidime after 2 h. Data suggest that ceftazidime-induced filamentation releases larger quantities of bioreactive LPS than nonfilamentous fast-lysing imipenem.
Exact polyhedral visual hulls (2003)

We propose an exact method for efficiently and robustly computing the visual hull of an object from image contours.Unlike most existing approaches, ours computes an exact description of the visual hull polyhedron associated to polygonal image contours.Furthermore, the proposed approach is fast and allows real-time recovery of both manifold and watertight visual hull polyhedra.The process involves three main steps.First, a coarse geometrical approximation of the visual hull is computed by retrieving its viewing edges, an unconnected subset of the wanted mesh.Then, local orientation and connectivity rules are used to walk along the relevant viewing cone intersection boundaries, so as to iteratively generate the missing surface points and connections.A final connection walkthrough allows us to identify the planar contours for each face of the polyhedron.Implementation details and results with synthetic and real data are presented.
Generating Binary Tags for Fast Medical Image Retrieval Based on Convolutional Nets and Radon Transform (2016)

Content-based image retrieval (CBIR) in large medical image archives is a challenging and necessary task. Generally, different feature extraction methods are used to assign expressive and invariant features to each image such that the search for similar images comes down to feature classification and/or matching. The present work introduces a new image retrieval method for medical applications that employs a convolutional neural network (CNN) with recently introduced Radon barcodes. We combine neural codes for global classification with Radon barcodes for the final retrieval. We also examine image search based on regions of interest (ROI) matching after image retrieval. The IRMA dataset with more than 14,000 x-rays images is used to evaluate the performance of our method. Experimental results show that our approach is superior to many published works.
Thermal Cycling and Surface Passivation of Micromachined Devices for PCR (1995)

Journal Article Thermal Cycling and Surface Passivation of Micromachined Devices for PCR Get access Clinical Chemistry, Volume 41, Issue 9, 1 September 1995, Pages 1367–1368, https://doi.org/10.1093/clinchem/41.9.1367 Published: 01 September 1995