gebhart/patrepeval huggingface dataset:
Coupled-defect photonic crystal vertical cavity surface emitting lasers (2003)

Photonic crystal patterns containing two defects were fabricated within a large gain area in vertical cavity surface emitting lasers. By designing effective refractive index changes in the region between the defects through cavity shifts caused by photonic crystals, it was possible to coherently couple laser light output from the defects. This enables a novel way to fabricate coherently coupled laser arrays.
Interactive effects of added L-carnitine and chromium picolinate on sow reproductive performance (2001)

A total of 599 sows were used to determine the effects of added L-carnitine and/or chromium picolinate on reproductive performance. Experimental treatments were arranged in a 2 Ã— 2 factorial with main effects of added L-carnitine (0 or 50 ppm) and chromium picolinate (0 or 200 ppb). Starting on the first day of breeding, sows were provided a daily top dress containing the carnitine and(or) chromium along with the standard gestation diet. Dietary treatments were administered daily through the initial gestation, lactation, and through a second gestation period (2 parities). During the first parity, there was a carnitine Ã— chromium interaction (P<0.01) for first service farrowing rate. Added dietary chromium increased (P<0.01) first service farrowing rate, but not when carnitine was added. No differences (P>0.05) were observed in number of pigs born alive, still born, mummies, or total born in the first parity. Added dietary L-carnitine decreased (P<0.05) wean to estrus interval, and tended to increase (P<0.08) the number of sows in estrus by d 7. In the second parity, a tendency (P<.08) for a carnitine Ã— chromium interaction was found for first service farrowing rate. Adding carnitine and chromium together in the diet increased first service farrowing rate compared to either product alone. Because of the change in wean-to-estrus interval and farrowing rate, feeding additional dietary carnitine and chromium increased (P<0.04) the percentage of sows that were weaned from parity 1 and farrowed in parity 2. When calculating the total number of pigs and number born alive based on all sows that were started on test, both added carnitine and chromium increased the number of pigs born and born alive. These results show that carnitine and chromium supplementation improved return-to- estrus interval and farrowing rate and, thus, total number born alive over two parities.; Swine Day, Manhattan, KS, November 15, 2001
ChemInform Abstract: HIV‐1 Integrase Inhibitors: 2005—2006 Update (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Water and Methanol Uptakes in Nafion Membranes and Membrane Effects on Direct Methanol Cell Performance (2000)

This paper compares direct methanol fuel cells (DMFCs) employing two types of Nafion® (E.I. DuPont de Nemours and Company) membranes of different equivalent weight (EW). Methanol and water uptakes in 1100 and 1200 EW Nafion membranes were determined by weighing and methanol solution‐equilibrated membranes. Both methanol and water uptakes in the 1200 EW membrane were about 70–74% of those in the 1100 EW membrane. The methanol crossover rate corresponding to that in a DMFC at open circuit was measured using a voltammetric method in the DMFC configuration and under the same cell operating conditions. After accounting for the thickness difference between the membrane samples, the methanol crossover rate through a 1200 EW membrane was 52% of that through an 1100 EW membrane. To resolve the cathode and anode performances in an operating DMFC, a dynamic hydrogen electrode was used as a reference electrode. Results show that in an operating DMFC the cathode can be easily flooded, as shown in a DMFC using 1100 EW membrane. An increase in methanol crossover rate decreases the DMFC cathode potential at open circuit. At a high cell current density, the DMFC cathode potential can approach that of a cell. © 2000 The Electrochemical Society. All rights reserved.
Quantitative characterization of the trapped charge profile in GaN HEMTs by sense nodes in the drain-extension region (2016)

A new methodology is presented that directly extracts the location and amount of trapped charge in GaN HEMTs by making use of a special test structure with an additional sense node in-between the gate and drain. The technique is validated on three wafer types: one for which trapping predominantly occurs in the GaN epitaxy, one with both epitaxy trapping and surface charge injection, and one for our optimized 650-V GaN technology, for which charge trapping is almost completely eliminated.
BLU (2017)

Deploying LTE networks in unlicensed spectrum requires us to move beyond coexistence mechanisms and understand the suitability of LTE's synchronous operation in a spectrum that is governed by asynchronous access principles. Our study reveals a fundamental conflict in LTE uplink access that arises between the scheduled nature of LTE's multi-user transmissions -- critical for leveraging the diversity (OFDMA) and multiplexing (multi-user MIMO) gains -- and the asynchronous nature of interference on the clients. The result is a significant loss in spectrum utilization and throughput that scales with the number of interfering terminals.
Multiplexed Tracking of Protease Activity Using a Single Color of Quantum Dot Vector and a Time-Gated Förster Resonance Energy Transfer Relay (2012)

Semiconductor quantum dots (QDs) are attractive probes for optical sensing and imaging due to their unique photophysical attributes and nanoscale size. In particular, the development of assays and biosensors based on QDs and Förster resonance energy transfer (FRET) continues to be a prominent focus of research. Here, we demonstrate the application of QDs as simultaneous donors and acceptors in a time-gated FRET relay for the multiplexed detection of protease activity. In contrast to the current state-of-the-art, which uses multiple colors of QDs, multiplexing was achieved using only a single color of QD. The other constituents of the FRET relay, a luminescent terbium complex and fluorescent dye, were assembled to QDs via peptides that were selected as substrates for the model proteases trypsin and chymotrypsin. Loss of prompt FRET between the QD and dye signaled the activity of chymotrypsin; loss of time-gated FRET between the terbium and QD signaled the activity of trypsin. We applied the FRET relay in a series of quantitative, real-time kinetic assays of increasing biochemical complexity, including multiplexed sensing, measuring inhibition in a multiplexed format, and tracking the proteolytic activation of an inactive pro-protease to its active form in a coupled, multienzyme system. These capabilities were derived from a ratiometric analysis of the two FRET pathways in the relay and permitted extraction of initial reaction rates, enzyme specificity constants, and apparent inhibition constants. This work adds to the growing body of research on multifunctional nanoparticles and introduces multiplexed sensing as a novel capability for a single nanoparticle vector. Furthermore, the ability to track both enzymes within a coupled biological system using one vector represents a significant advancement for nanoparticle-based biosensing. Prospective applications in biochemical research, applied diagnostics, and drug discovery are discussed.
ChemInform Abstract: Biologically‐Validated HIV Integrase Inhibitors with Nucleobase Scaffolds: Structure, Synthesis, Chemical Biology, Molecular Modeling, and Antiviral Activity (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Alignment System Of Proton Accelerators For Cancer Therapy (2006)

The high accurate alignment system to install proton accelerator is developed. The accelerator has a number of electromagnets, which control the orbit of a proton beam. These electromagnets have to be installed with very high accuracy (design value ±0.1mm) by 3D measurement and position adjustment operations. A laser tracker is used to get the 3D coordinates of the electromagnet. And 10 position adjustment bolts, which are put in a mount of the electromagnet, are used to adjust the position of the electromagnet. However, the conventional method is inefficient and makes it difficult to predict the installation time of an electromagnet, because the 3D measurement and bolt operation are repeated time and time again till the electromagnet is installed to a target position. The alignment system we developed has the laser tracker, dial gages and a control unit. Dial gages are used to measure operational amounts of the position adjustment bolts. The system can calculate the optimum operational amounts of the bolts by obtaining the Jacobean matrix between the operated variables of the bolts and the 3D position changes of the electromagnet. This paper describes an overview of the alignment system, the calculation method of the optimum operational amount of the bolts, and the results of an experimental alignment using a mock-up of the electromagnet.
Delay hopped transmitted reference experimental results (2003)

This paper describes the experimental hardware design and implementation for a delay hopped transmitted reference communication system. The hardware is designed to generate the delay hopped transmitted reference signal for a number of experimental conditions. It can be used either in an ultra wideband pulse mode, ultra wideband noise mode, or in a narrowband mode. We use the experimental hardware setup to conduct link experiments with a delay hopped transmitted reference communication system. Experiments were conducted in an indoor multipath environment to test the viability of delay hopped transmitted reference for short-range indoor communications. The experimental results presented demonstrate that this modulation format is capable of transmitting data short range indoors without line of sight transmission path with minimal transmitted RF power.
Corpus-based unit selection for natural-sounding speech synthesis (2003)

Speech synthesis is an automatic encoding process carried out by machine through which symbols conveying linguistic information are converted into an acoustic waveform. In the past decade or so, a recent trend toward a non-parametric, corpus-based approach has focused on using real human speech as source material for producing novel natural-sounding speech. This work proposes a communication-theoretic formulation in which unit selection is a noisy channel through which an input sequence of symbols passes and an output sequence, possibly corrupted due to the coverage limits of the corpus, emerges. The penalty of approximation is quantified by substitution and concatenation costs which grade what unit contexts are interchangeable and where concatenations are not perceivable. These costs are semi-automatically derived from data and are found to agree with acoustic-phonetic knowledge.
Slope-matched dispersion-compensating photonic crystal fibre (2004)

Brian J. Mangan, Francois Couny, Lance Farr, Alan Langford, P John. Roberts, David P. Williams, Matthew Banham, Matt W. Mason, Dominic F. Murphy, Elsa A. M. Brown, Hendrik Sabert, Tim A. Birks, Jonathan C. Knight, and Philip St. J. Russell
Sobel filter for edge detection of hexagonally sampled 3D seismic data (2016)

ABSTRACT In today’s industry, automatic detection of geologic features such as faults and channels is a challenging problem when the quality of data is not good. Edge detection filters are generally applied for the purpose of locating such features. Until now, edge detection has been carried out on rectangularly sampled 3D seismic data. The computational cost of edge detection can be reduced by exploring other sampling approaches instead of the regular rectangular sampling commonly used. Hexagonal sampling is an alternative to rectangular sampling that requires 13.4% less samples for the same level of accuracy. The hexagonal approach is an efficient method of sampling with greater symmetry compared with the rectangular approach. Spiral architecture can be used to handle the hexagonally sampled seismic data. Spiral architecture is an attractive scheme for handling 2D images that enables processing 2D data as 1D data in addition to the inherent hexagonal sampling advantages. Thus, the savings in number of samples, greater symmetry, and efficient data handling capability makes hexagonal sampling an ideal choice for computationally exhaustive operations. For the first time to our knowledge, we have made an attempt to detect edges in hexagonally sampled seismic data using spiral architecture. We compared edge detection on rectangular and hexagonally sampled seismic data using 2D and 3D filters in rectangular and hexagonal domains. We determined that hexagonal processing results in exceptional computational savings, when compared with its rectangular processing counterpart.
The use of hydrogen‐deuterium exchange to facilitate peptide sequencing by electrospray tandem mass spectrometry (1993)

The utility of hydrogen-deuterium exchange for sequencing peptides by mass spectrometry is demonstrated. The number of exchangeable hydrogens in a peptide is readily obtained by electrospray analysis of the peptide dissolved in deuterated solvents. This information can be used, in conjunction with published computer algorithms for interpreting peptide mass spectra, to reduce significantly the number of candidate sequences that fit the experimental data. This information, when combined with fragment-ion information in the mass spectrum, greatly increases the reliability of sequence determination.
Improved Algorithms for the Evacuation Route Planning Problem (2016)

Emergency evacuation is the process of movement of people away from the threat or actual occurrence of hazards such as natural disasters, terrorist attacks, fires and bombs. In this paper, we focus on evacuation from a building, but the ideas can be applied to city and region evacuation. We define the problem and show how it can be modeled using graphs. The resulting optimization problem can be formulated as an integer linear program. Though this can be solved exactly, this approach does not scale well for graphs with thousands of nodes and several hundred thousands of edges. This is impractical for large graphs. We study a special case of this problem, where there is only a single source and a single sink. For this case, we give an improved algorithm \emph{Single Source Single Sink Evacuation Route Planner (SSEP)}, whose evacuation time is always at most that of a famous algorithm \emph{Capacity Constrained Route Planner (CCRP)}, and whose running time is strictly less than that of CCRP. We prove this mathematically and give supporting results by extensive experiments. We also study randomized behavior model of people and give some interesting results.
Room-temperature single phase multiferroic magnetoelectrics: Pb(Fe, M)x(Zr,Ti)(1−x)O3 [M = Ta, Nb] (2013)

We describe extensive studies on a family of perovskite oxides that are ferroelectric and ferromagnetic at ambient temperatures. The data include x-ray diffraction, Raman spectroscopy, measurements of ferroelectric and magnetic hysteresis, dielectric constants, Curie temperatures, electron microscopy (both scanning electron microscope and transmission electron microscopy (TEM)) studies, and both longitudinal and transverse magnetoelectric constants α33 and α31. The study extends earlier work to lower Fe, Ta, and Nb concentrations at the B-site (from 15%–20% down to 5%). The magnetoelectric constants increase supralinearly with Fe concentrations, supporting the earlier conclusions of a key role for Fe spin clustering. The room-temperature orthorhombic C2v point group symmetry inferred from earlier x-ray diffraction studies is confirmed via TEM, and the primitive unit cell size is found to be the basic perovskite Z = 1 structure of BaTiO3, also the sequence of phase transitions with increasing temperature from rhombohedral to orthorhombic to tetragonal to cubic mimics barium titanate.
Tree-Structured Clustering Methods for Piecewise Linear-Transformation-Based Noise Adaptation (2005)

This paper proposes the application of tree-structured clustering to the processing of noisy speech collected under various SNR conditions in the framework of piecewise-linear transformation (PLT)-based HMM adaptation for noisy speech. Three kinds of clustering methods are described: a one-step clustering method that integrates noise and SNR conditions and two two-step clustering methods that construct trees for each SNR condition. According to the clustering results, a noisy speech HMM is made for each node of the tree structure. Based on the likelihood maximization criterion, the HMM that best matches the input speech is selected by tracing the tree from top to bottom, and the selected HMM is further adapted by linear transformation. The proposed methods are evaluated by applying them to a Japanese dialogue recognition system. The results confirm that the proposed methods are effective in recognizing digitally noise-added speech and actual noisy speech issued by a wide range of speakers under various noise conditions. The results also indicate that the one-step clustering method gives better performance than the two-step clustering methods.
Short-chain fatty acids in cancer pathogenesis (2023)

Cancer is a multi-step process that can be viewed as a cellular and immunological shift away from homeostasis in response to selected infectious agents, mutations, diet, and environmental carcinogens. Homeostasis, which contributes importantly to the definition of "health," is maintained, in part by the production of short-chain fatty acids (SCFAs), which are metabolites of specific gut bacteria. Alteration in the composition of gut bacteria, or dysbiosis, is often a major risk factor for some two dozen tumor types. Dysbiosis is often characterized by diminished levels of SCFAs in the stool, and the presence of a "leaky gut," permitting the penetration of microbes and microbial derived molecules (e.g., lipopolysaccharides) through the gut wall, thereby triggering chronic inflammation. SCFAs attenuate inflammation by inhibiting the activation of nuclear factor kappa B, by decreasing the expression of pro-inflammatory cytokines such as tumor necrosis factor alpha, by stimulating the expression of anti-inflammatory cytokines such as interleukin-10 and transforming growth factor beta, and by promoting the differentiation of naïve T cells into T regulatory cells, which down-regulate immune responses by immunomodulation. SCFA function epigenetically by inhibiting selected histone acetyltransferases that alter the expression of multiple genes and the activity of many signaling pathways (e.g., Wnt, Hedgehog, Hippo, and Notch) that contribute to the pathogenesis of cancer. SCFAs block cancer stem cell proliferation, thereby potentially delaying or inhibiting cancer development or relapse by targeting genes and pathways that are mutated in tumors (e.g., epidermal growth factor receptor, hepatocyte growth factor, and MET) and by promoting the expression of tumor suppressors (e.g., by up-regulating PTEN and p53). When administered properly, SCFAs have many advantages compared to probiotic bacteria and fecal transplants. In carcinogenesis, SCFAs are toxic against tumor cells but not to surrounding tissue due to differences in their metabolic fate. Multiple hallmarks of cancer are also targets of SCFAs. These data suggest that SCFAs may re-establish homeostasis without overt toxicity and either delay or prevent the development of various tumor types.
Narrowly Dispersed Hydrophilic Molecularly Imprinted Polymer Nanoparticles for Efficient Molecular Recognition in Real Aqueous Samples Including River Water, Milk, and Bovine Serum (2012)

In river water, milk, and bovine serum, molecularly imprinted polymer nanoparticles with hydrophilic polymer brushes showed excellent molecular recognition (see picture). Readily prepared by precipitation polymerization with a macromolecular chain-transfer agent, such nanoparticles are promising alternatives to antibodies for many applications owing to their superior dispersion and binding properties in biological matrices.
Optimizing top-k selection queries over multimedia repositories (2004)

Repositories of multimedia objects having multiple types of attributes (e.g., image, text) are becoming increasingly common. A query on these attributes will typically, request not just a set of objects, as in the traditional relational query model (filtering), but also a grade of match associated with each object, which indicates how well the object matches the selection condition (ranking). Furthermore, unlike in the relational model, users may just want the k top-ranked objects for their selection queries for a relatively small k. In addition to the differences in the query model, another peculiarity of multimedia repositories is that they may allow access to the attributes of each object only through indexes. We investigate how to optimize the processing of top-k selection queries over multimedia repositories. The access characteristics of the repositories and the above query model lead to novel issues in query optimization. In particular, the choice of the indexes used to search the repository strongly influences the cost of processing the filtering condition. We define an execution space that is search-minimal, i.e., the set of indexes searched is minimal. Although the general problem of picking an optimal plan in the search-minimal execution space is NP-hard, we present an efficient algorithm that solves the problem optimally with respect to our cost model and execution space when the predicates in the query are independent. We also show that the problem of optimizing top-k selection queries can be viewed, in many cases, as that of evaluating more traditional selection conditions. Thus, both problems can be viewed together as an extended filtering problem to which techniques of query processing and optimization may be adapted.
Clavaric Acid:  A Triterpenoid Inhibitor of Farnesyl-Protein Transferase from <i>Clavariadelphus </i><i>t</i><i>runcatus</i> (1998)

Farnesyl-protein transferase (FPTase) catalyses the specific transfer of farnesyl to Ras-peptides that is essential for oncogenic activity in oncogene-mediated tumors. Specific inhibition of FPTase activity has been shown to reduce tumor development in nude mice challenged with oncogenic forms of ras, thereby establishing FPTase as a viable therapeutic target. Our continued efforts to discover inhibitors of FPTase has led to the discovery of a triterpenoidal inhibitor, clavaric acid (1). This compound inhibits rHFPTase with an IC50 value of 1.3 microM. Structure elucidation, structure modifications, and biological activity of clavaric acid are herein described.