gebhart/patrepeval huggingface dataset:
Mammary Carcinomas Induced in Human c‐Ha‐<i>ras</i> Proto‐oncogene Transgenic Rats Are Estrogen‐independent, but Responsive to <i>d</i>‐Limonene Treatment (2002)

We have previously shown that transgenic rats carrying three copies of the human c-Ha-ras proto-oncogene (Hras128) are highly susceptible to N-methyl-N-nitrosourea (MNU) mammary carcinogenesis. All transgenic rats treated with 50 mg / kg MNU, i.v. at 50 days of age, were found to rapidly develop multiple, large mammary carcinomas within as short a period as 8 weeks. In the present study, the effects of ovariectomy and treatment with d-limonene, known to inhibit mammary carcinogenesis in non-transgenic female rats, were investigated in Hras128 animals treated with MNU to clarify the role of the human c-Ha-ras proto-oncogene and to characterize the induced mammary carcinomas. Although ovariectomy completely inhibited development of mammary carcinomas in their wild-type counterparts, it did not affect either the incidence or the multiplicity of the mammary carcinomas in the Hras128 rats. On the other hand, treatment with d-limonene, an inhibitor of ras protein isoprenylation, inhibited the breast tumor development. These results indicate that aberrant c-Ha-ras gene expression is involved in ovarian hormone-independent growth and c-Ha-ras protein isoprenylation plays an important role in mammary carcinogenesis.
Adaptive clustering and interactive visualizations to support the selection of video clips (2011)

Although people are capturing more video with their mobile phones, digital cameras, and other devices, they rarely watch all that video. More commonly, users extract a still image from the video to print or a short clip to share with others. We created a novel interface for browsing through a video keyframe hierarchy to find frames or clips. The interface is shown to be more efficient than scrolling linearly through all keyframes. We developed algorithms for selecting quality keyframes and for clustering keyframes hierarchically. At each level of the hierarchy, a single representative keyframe from each cluster is shown. Users can drill down into the most promising cluster and view representative keyframes for the sub-clusters. Our clustering algorithms optimize for short navigation paths to the desired keyframe. A single keyframe is located using a non-temporal clustering algorithm. A video clip is located using one of two temporal clustering algorithms. We evaluated the clustering algorithms using a simulated search task. User feedback provided us with valuable suggestions for improvements to our system.
Enhanced plastic strain in Zr-based bulk amorphous alloys (2001)

Bulk metallic glasses subjected to quasistatic uniaxial compression at room temperature typically display large elastic strains but limited plastic flow of 0--2% before failure. We have developed an amorphous alloy, ${\mathrm{Zr}}_{59}{\mathrm{Ta}}_{5}{\mathrm{Cu}}_{18}{\mathrm{Ni}}_{8}{\mathrm{Al}}_{10},$ which experiences an average macroscopic plastic strain of 4.5% before failure. The as-cast alloy shows no evidence for the presence of crystalline phases, and displays a distinct glass transition temperature and a wide supercooled liquid region. Upon compression beyond the yield point, the alloy develops shear bands which show a pronounced tendency for branching. We propose that this shear band branching distributes the plastic strain on the shear band, thereby suppressing crack initiation and allowing the material to experience a large macroscopic plastic strain before failure.
Image Rendering for Microlens Array Imaging (2015)

In this paper we present an efficient image rendering method to recover a complete image from multiple micro-images captured by a microlens array. Non-uniform illumination is successfully addressed by illumination normalization based on a background model. Micro-image fusion is further improved by taking into account the distance weighting. Experimental results demonstrate that high quality images can be produced by the proposed method.
Monolithically, widely tunable quantum cascade lasers based on a heterogeneous active region design (2016)

Quantum cascade lasers (QCLs) have become important laser sources for accessing the mid-infrared (mid-IR) spectral range, achieving watt-level continuous wave operation in a compact package at room temperature. However, up to now, wavelength tuning, which is desirable for most applications, has relied on external cavity feedback or exhibited a limited monolithic tuning range. Here we demonstrate a widely tunable QCL source over the 6.2 to 9.1 μm wavelength range with a single emitting aperture by integrating an eight-laser sampled grating distributed feedback laser array with an on-chip beam combiner. The laser gain medium is based on a five-core heterogeneous QCL wafer. A compact tunable laser system was built to drive the individual lasers within the array and produce any desired wavelength within the available spectral range. A rapid, broadband spectral measurement (520 cm(-1)) of methane using the tunable laser source shows excellent agreement to a measurement made using a standard low-speed infrared spectrometer. This monolithic, widely tunable laser technology is compact, with no moving parts, and will open new opportunities for MIR spectroscopy and chemical sensing.
Piezoelectric-based broadband bistable vibration energy harvester and SCE/SSHI-based high-power extraction (2014)

This paper presents ambient mechanical vibrations as an alternative source for energy harvesting, especially beneficial where alternatives such as light, wind, biomass and thermal energy are limited, e.g., powering underground sensors. Transduction of ambient kinetic energy, e.g., the vibrations from thunder and field work, into electrical energy using piezoelectric generators has been investigated, utilizing a nonlinear bistable broadband piezoelectric harvester. A new model for the bistable piezoelectric harvester is suggested based on the standard Butterworth van Dyke model and its validity demonstrated through simulations. For efficient extraction of the transduced energy, we employ synchronous charge extraction (SCE) and parallel synchronized switch harvesting on inductor (SSHI). The switching in these circuits is implemented using a fully self-propelled, low-power electronic breaker circuit, capable of detecting extrema in the input to perform switching. The power outputs from simulation of the bistable harvester have been presented, with the SCE and parallel SSHI providing respective average outputs of 78.5μW and 125μW for a sinusoidal input of 0.326N at 10Hz applied to a 69.1 × 16.8 × 0.64 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> cantilever (piezoelectric dimensions 35.56 × 14.48 × 0.2 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ). This shows significant gains over the harvested power reported in literature.
Abstract B50: Selectively targeting prostate cancer with antiandrogen-equipped histone deacetylase inhibitors (2013)

Abstract Diverse cellular processes relevant to cancer progression are regulated by the acetylation status of proteins, such as chromatin remodeling via histone proteins, controlled by opposing histone deacetylase (HDAC) and histone acetyltransferase (HAT) enzymes. Histone deacetylase inhibitors (HDACi) show great promise in preclinical cancer models, but clinical trials for solid tumors have failed to improve patient survival. This is due in part to an inability of HDACi to effectively accumulate in cancerous cells. To address this problem we designed HDACi with secondary pharmacophores to facilitate selective enrichment in malignant cells. We present the first example of HDACi compounds targeted to prostate tumors by equipping them (via “click” chemistry) with the secondary ability to bind the androgen receptor (AR) with non-steroidal antiandrogen moieties. Leads among these new duel-acting molecules bind to the AR and halt AR transcriptional activity at lower concentrations than clinical antiandrogens. They inhibit key isoforms of HDAC with improved potency over clinically approved HDACi, SAHA. Fluorescent microscopy reveals varying degrees of AR nuclear localization in response to these compounds. These biological properties translate into anticancer activity against hormone independent (AR-) DU145 prostate cancer, and even more so against hormone dependent (AR+) LNCaP, while having greatly reduced toxicity in non-cancerous cells. These compounds illustrate a “smart bomb” approach towards achieving selective, safe, and potent cancer therapies. Citation Format: Berkley E. Gryder, Michelle J. Akbashev, Michael K. Rood, Paulette Dillard, Shafiq Khan, Adegboyega K. Oyelere. Selectively targeting prostate cancer with antiandrogen-equipped histone deacetylase inhibitors. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr B50.
Longitudinal and Lateral Control for Automated Yielding Maneuvers (2016)

Automated driving is predicted to enhance traffic safety, transport efficiency, and driver comfort. To extend the capability of current advanced driver assistance systems, and eventually realize fully automated driving, the intelligent vehicle system must have the ability to plan different maneuvers while adapting to the surrounding traffic environment. This paper presents an algorithm for longitudinal and lateral trajectory planning for automated driving maneuvers where the vehicle does not have right of way, i.e., yielding maneuvers. Such maneuvers include, e.g., lane change, roundabout entry, and intersection crossing. In the proposed approach, the traffic environment which the vehicle must traverse is incorporated as constraints on its longitudinal and lateral positions. The trajectory planning problem can thereby be formulated as two loosely coupled low-complexity model predictive control problems for longitudinal and lateral motion. Simulation results demonstrate the ability of the proposed trajectory planning algorithm to generate smooth collision-free maneuvers which are appropriate for various traffic situations.
Wideband coherent DS-CDMA (2002)

A coherent CDMA access architecture that supports multimedia services and also flexible system deployment is described. For the flexible use of the limited radio frequency resources, a multiple-band system is suitable. The bandwidth selected depends on the maximum data rate to be supported. This paper focuses on a 10 MHz coherent DS-CDMA system because it provides a generic model for systems using different bandwidths. Pilot symbol-aided coherent RAKE reception in the reverse link is employed to enhance the transmission quality. To allow flexible system deployment, a combination of short and long codes as spreading codes and signal-to-interference (SIR) based transmit power control are used. To flexibly offer multiple bit rate services, the traffic channel (TCH) has a maximum bit rate of 128 kbps. Within each single 128 kbps TCH, variable rate speech or low rate packet data can be transmitted based on data activated discontinuous transmission to achieve statistical multiplexing effects. Bit rate transmission higher than 128 kbps can be achieved with code multiplexing. The capacity and personal terminal transmit power of the proposed system are evaluated.
Three Artificial Spintronic Leaky Integrate-and-Fire Neurons (2020)

Due to their nonvolatility and intrinsic current integration capabilities, spintronic devices that rely on domain wall (DW) motion through a free ferromagnetic track have garnered significant interest in the field of neuromorphic computing. Although a number of such devices have already been proposed, they require the use of external circuitry to implement several important neuronal behaviors. As such, they are likely to result in either a decrease in energy efficiency, an increase in fabrication complexity, or even both. To resolve this issue, we have proposed three individual neurons that are capable of performing these functionalities without the use of any external circuitry. To implement leaking, the first neuron uses a dipolar coupling field, the second uses an anisotropy gradient and the third uses shape variations of the DW track.
Abstract 3278: Novel knock-in mice expressing human/mouse chimeric endoglin (ENG; CD105) develop normally and will be valuable for evaluating clinical application of anti-human ENG antibodies (2011)

Abstract The major objective of this study is to develop a novel animal model to facilitate optimal clinical application of anti-human ENG (huENG) monoclonal antibodies (mAbs) to treat cancer patients. ENG is a proliferation-associated homodimeric cell membrane antigen of endothelial cells and leukemia cells. It is strongly expressed on angiogenic vascular endothelium in tumors and also expressed in lymphatic vessels in tumors. Furthermore, ENG is a TGF-β coreceptor and essential for angiogenesis/vascular development. Mice lacking ENG die from defective vascular development. Mutations in the huENG gene are associated with hereditary hemorrhagic telangiectasia type 1 (HHT1) which is characterized by vascular malformations and recurrent bleeding. huENG shows a relatively restricted expression pattern in tissues and cells. We hypothesized that huENG is a safe and effective target in vascular-targeting antiangiogenic therapy (VTAT). Clinical trials of a chimeric anti-huENG mAb c-SN6j (also known as TRC105) are in progress (ClinicalTrials.gov Identifier: NCT00582985 and NCT01090765). The major obstacle in animal model studies of anti-huENG mAbs is that most anti-huENG mAbs do not react with mouse ENG or mouse endothelial cells. To overcome this obstacle, we generated knock-in mice expressing human/mouse chimeric ENG. We designed the chimeric vectors to contain huENG gene segments of desired location and length so that the expressed huENG protein contains desired epitopes. Nevertheless, the major concern was that the generated knock-in mice might suffer from defective vascular development or HHT-like symptoms if the chimeric ENG does not function properly in mice. We generated two types of knock-in mice containing different sizes of huENG gene. In both cases, mice develop normally and show no sign of HHT-like symptoms in the homozygous mice. Tumors of 4T1 breast cancer cells and Colon26 colon cancer cells were generated in the knock-in mice to test expression of chimeric ENG protein in the tumor microvessels. Immunohistochemical staining of the tumors using several anti-huENG mAbs showed that the tumor microvessels express desired epitopes of huENG protein which are candidate targets for VTAT. The epitopes defined by these mAbs have been mapped. This novel knock-in mouse model will be useful for evaluating antitumor efficacy of many anti-huENG mAbs. In addition, this model will be useful for evaluating appropriate combination of an anti-huENG mAb with other anticancer agents to achieve optimal antitumor efficacy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3278. doi:10.1158/1538-7445.AM2011-3278
High‐temperature thermoplastic elastomers via the grafting reaction of polyarylate onto EPDM rubber (1993)

Abstract Polyarylate monofunctionally terminated with a 1,2‐dihydrobenzocyclobutene group undergoes thermally initiated grafting reactions onto ethylene/propylene/nonconjugated diene rubber via the Diels—Alder reaction between the diene (benzocyclobutene) and the dienophile (pendant unsaturation on the EPDM). Characterization of the graft copolymer(s) is presented as is the resultant thermoplastic elastomeric mechanical performance exhibited by the graft copolymers. © 1993 John Wiley & Sons, Inc.
Saline Water-Based Mineralization Pathway for Gigatonne-Scale CO<sub>2</sub>Management (2021)

This perspective proposes a potential pathway to diminish atmospheric CO2 accumulations which is distinct from traditional carbon capture and geological sequestration strategies and from existing negative emissions technologies (NETs). Unlike conventional sorbent- or solvent-based CO2 capture processes where substantial energy expenditures are associated with demixing and desorbing CO2, the single-step carbon sequestration and storage (sCS2) approach relies on electrolytic carbonate mineral precipitation using renewable energy within a simple and scalable process design. Although numerous approaches have implied electrolysis for carbon management, the sCS2 approach is unique in the following ways: (1) CO2 mineralization for promoting solid carbonate formation: The thermodynamic and kinetic barriers to carbonate precipitation are overcome by direct and in situ electrochemical forcing to stabilize dissolved inorganic carbon and divalent cations [Ca,Mg] to form carbonate minerals. (2) Flow-through membraneless electrolysis: A flowing electrolyte (seawater) is dissociated while in motion. The process utilizes cost-effective mesh electrodes while also decreasing the number of components and assembly steps and reducing the risk of device failure. (3) Integrated electrolytic reactor–rotary drum filter: An electroactive thin-film mesh cathode (eTFC) is suggested to be integrated within a rotary drum filter configuration, allowing for the filtration of dilute and polydispersed mineral precipitates at a low energy cost. These attributes render sCS2 as an approach worthy of more detailed evaluation, development, and scaling for global-scale carbon management.
Apparatus and method for playing back audio at faster or slower rates without pitch distortion (1995)

First Page
Cruentaren A Binds F<sub>1</sub>F<sub>0</sub> ATP Synthase To Modulate the Hsp90 Protein Folding Machinery (2014)

The molecular chaperone Hsp90 requires the assistance of immunophilins, co-chaperones, and partner proteins for the conformational maturation of client proteins. Hsp90 inhibition represents a promising anticancer strategy due to the dependence of numerous oncogenic signaling pathways upon Hsp90 function. Historically, small molecules have been designed to inhibit ATPase activity at the Hsp90 N-terminus; however, these molecules also induce the pro-survival heat shock response (HSR). Therefore, inhibitors that exhibit alternative mechanisms of action that do not elicit the HSR are actively sought. Small molecules that disrupt Hsp90-co-chaperone interactions can destabilize the Hsp90 complex without induction of the HSR, which leads to inhibition of cell proliferation. In this article, selective inhibition of F1F0 ATP synthase by cruentaren A was shown to disrupt the Hsp90-F1F0 ATP synthase interaction and result in client protein degradation without induction of the HSR.
Integration of SNR, load and time in handoff initiation for wireless LAN (2004)

The performance of handoff initiation algorithm is one of the key issues for providing roaming capability in wireless LAN (WLAN). In this paper, we propose a new handoff initiation algorithm for data transmitting in WLAN. Our proposal combines association time, system load and signal/noise ratio (SNR) together to decide whether mobile node should handoff or not. The goal is to reduce the number of unnecessary handoff, decrease packet loss and balance the system load. In this way, we can provide quality of service (QoS) guarantee. Simulation results show that the proposed handoff initiation algorithm is efficient in WLAN.
Far-IR quantum cascade lasers at 21.5 µm wavelength (2001)

Quantum Cascade (QC) lasers have established themselves rapidly as tunable coherent sources in the mid-infrared (MIR) range of the electromagnetic spectrum.1 The frontier of research has consequently expanded to further topics like the use of different material systems, ultrafast behavior and the exploration of new frequency ranges.2,3,4
Targeting prostate cancer with radiolabelled bombesins (2006)

The fact that a number of common human tumours, including those of breast and prostate, express increased levels of the gastrin-releasing peptide receptor (GRP-R) means that this receptor is a potential target for peptide receptor mediated scintigraphy and targeted radionuclide therapy. Although clinical application is yet in its infancy, there is a considerable literature on preclinical studies aimed at developing suitable radioligands for potential clinical application. This brief review provides an overview of this research and also describes some of the limited clinical studies that have been published.
Graft copolymer compatibilizers for blends of isotactic polypropylene and ethene-propene copolymers. 2. Functional polymers approach (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGraft copolymer compatibilizers for blends of isotactic polypropylene and ethene-propene copolymers. 2. Functional polymers approachSudhin Datta and David J. LohseCite this: Macromolecules 1993, 26, 8, 2064–2076Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ma00060a040https://doi.org/10.1021/ma00060a040research-articleACS PublicationsRequest reuse permissionsArticle Views429Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts