gebhart/patrepeval huggingface dataset:
DeepWrinkles: Accurate and Realistic Clothing Modeling (2018)

We present a novel method to generate accurate and realistic clothing deformation from real data capture. Previous methods for realistic cloth modeling mainly rely on intensive computation of physics-based simulation (with numerous heuristic parameters), while models reconstructed from visual observations typically suffer from lack of geometric details. Here, we propose an original framework consisting of two modules that work jointly to represent global shape deformation as well as surface details with high fidelity. Global shape deformations are recovered from a subspace model learned from 3D data of clothed people in motion, while high frequency details are added to normal maps created using a conditional Generative Adversarial Network whose architecture is designed to enforce realism and temporal consistency. This leads to unprecedented high-quality rendering of clothing deformation sequences, where fine wrinkles from (real) high resolution observations can be recovered. In addition, as the model is learned independently from body shape and pose, the framework is suitable for applications that require retargeting (e.g., body animation). Our experiments show original high quality results with a flexible model. We claim an entirely data-driven approach to realistic cloth wrinkle generation is possible.
A new approach for recycling optical disks (2002)

Responding to the increase of optical disk waste, we developed a new technology for recycling disks especially for CD-R (CD write-once). This technology enables not only material recycling of the gold reflection layer and dye in the recording layer, but also reuse of polycarbonate disk substrates to produce new disks.
Functional Replacement of Ferredoxin by a Cyanobacterial Flavodoxin in Tobacco Confers Broad-Range Stress Tolerance (2006)

Chloroplast ferredoxin (Fd) plays a pivotal role in plant cell metabolism by delivering reducing equivalents to various essential oxidoreductive pathways. Fd levels decrease under adverse environmental conditions in many microorganisms, including cyanobacteria, which share a common ancestor with chloroplasts. Conversely, stress situations induce the synthesis of flavodoxin (Fld), an electron carrier flavoprotein not found in plants, which can efficiently replace Fd in most electron transfer processes. We report here that chloroplast Fd also declined in plants exposed to oxidants or stress conditions. A purified cyanobacterial Fld was able to mediate plant Fd-dependent reactions in vitro, including NADP+ and thioredoxin reduction. Tobacco (Nicotiana tabacum) plants expressing Fld in chloroplasts displayed increased tolerance to multiple sources of stress, including redox-cycling herbicides, extreme temperatures, high irradiation, water deficit, and UV radiation. Oxidant buildup and oxidative inactivation of thioredoxin-dependent plastidic enzymes were decreased in stressed plants expressing plastid-targeted Fld, suggesting that development of the tolerant phenotype relied on productive interaction of this flavoprotein with Fd-dependent oxidoreductive pathways of the host, most remarkably, thioredoxin reduction. The use of Fld provides new tools to investigate the requirements of photosynthesis in planta and to increase plant stress tolerance based on the introduction of a cyanobacterial product that is free from endogenous regulation in higher plants.
Arterivirus and Nairovirus Ovarian Tumor Domain-Containing Deubiquitinases Target Activated RIG-I To Control Innate Immune Signaling (2011)

The innate immune response constitutes the first line of defense against viral infection and is extensively regulated through ubiquitination. The removal of ubiquitin from innate immunity signaling factors by deubiquitinating enzymes (DUBs) therefore provides a potential opportunity for viruses to evade this host defense system. It was previously found that specific proteases encoded by the unrelated arteri- and nairoviruses resemble the ovarian tumor domain-containing (OTU) family of DUBs. In arteriviruses, this domain has been characterized before as a papain-like protease (PLP2) that is also involved in replicase polyprotein processing. In nairoviruses, the DUB resides in the polymerase protein but is not essential for RNA replication. Using both in vitro and cell-based assays, we now show that PLP2 DUB activity is conserved in all members of the arterivirus family and that both arteri- and nairovirus DUBs inhibit RIG-I-mediated innate immune signaling when overexpressed. The potential relevance of RIG-I-like receptor (RLR) signaling for the innate immune response against arterivirus infection is supported by our finding that in mouse embryonic fibroblasts, the production of beta interferon primarily depends on the recognition of arterivirus RNA by the pattern-recognition receptor MDA5. Interestingly, we also found that both arteri- and nairovirus DUBs inhibit RIG-I ubiquitination upon overexpression, suggesting that both MDA5 and RIG-I have a role in countering infection by arteriviruses. Taken together, our results support the hypothesis that arteri- and nairoviruses employ their deubiquitinating potential to inactivate cellular proteins involved in RLR-mediated innate immune signaling, as exemplified by the deubiquitination of RIG-I.
A Thermal Dehydrogenative Diels–Alder Reaction of Styrenes for the Concise Synthesis of Functionalized Naphthalenes (2012)

Functionalized naphthalenes are valuable building blocks in many important areas. A microwave-assisted, intramolecular dehydrogenative Diels-Alder reaction of styrenyl derivatives to provide cyclopenta[b]naphthalene substructures not previously accessible using existing synthetic methods is described. The synthetic utility of these uniquely functionalized naphthalenes was demonstrated by a single-step conversion of one of these cycloadducts to a fluorophore bearing a structural resemblance to Prodan.
Antineoplastic Agents, 325. Isolation and Structure of the Human Cancer Cell Growth Inhibitory Cyclic Octapeptides Phakellistatin 10 and 11 from Phakellia sp. (1995)

The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia (ED50 values of 2.1 and 0.20 micrograms/ml, respectively) and human cancer cell lines. The structures were established based on results of extensive tandem ms/ms and high-field (500-MHz) 2D 1H- and 13C-nmr analyses. All of the amino acid units (except Trp, not determined) were found to correspond to the (S)-configuration.
Singular Electric Field Terahertz Emitters and Detectors. (1997)

We present a new family of more efficient terahertz (THz) radiation emitters and detectors enhanced by electric field singularities near sharp electrode features. The structures are fabricated on low temperature GaAs and with small dipole gaps (<10μm). The THz emission is maximal when fringing fields are enhanced by laterally offset sharp electrodes. We also find that the asymmetric THz emission near the anode gradually disappears as the dipole gap shrinks. The THz polarization properties of these new emitters will also be discussed.
Ulvan Lyases Isolated from the Flavobacteria Persicivirga ulvanivorans Are the First Members of a New Polysaccharide Lyase Family (2011)

Ulvans are complex sulfated polysaccharides found in the cell walls of green algae belonging to the genus Ulva. These polysaccharides are composed of disaccharide repetition moieties made up of sulfated rhamnose linked to either glucuronic acid, iduronic acid, or xylose. Two ulvan lyases of 30 and 46 kDa were purified from the culture supernatant of Persicivirga ulvanivorans. Based on peptide sequencing, the gene encoding the 46-kDa ulvan lyase was cloned. Sequence analysis revealed that the protein is modular and possesses a catalytic module similar to that of the 30-kDa ulvan lyase along with a module of unknown function. The ulvan-degrading function of the gene was confirmed by expression of the catalytic module in a heterologous system. The gene encoding the catalytic module has no sequence homolog in sequence databases and is likely to be the first member of a novel polysaccharide lyase family. Analysis of degradation products showed that both the 30- and 46-kDa ulvan lyases are endolytic and cleave the glycosidic bond between the sulfated rhamnose and a glucuronic or iduronic acid.
<i>WRINKLED1</i> encodes an AP2/EREB domain protein involved in the control of storage compound biosynthesis in Arabidopsis (2004)

The accumulation of storage compounds during seed development ensures the survival of the young seedling, and also provides nutrition to humans and animals in the form of foods and feeds. The putative AP2/EREBP transcription factor WRINKLED1 (WRI1) is involved in the regulation of seed storage metabolism in Arabidopsis. A splicing mutant allele, wri1-1, caused the reduction of seed oil accumulation. Glycolysis was compromised in this mutant, rendering developing embryos unable to efficiently convert sucrose into precursors of triacylglycerol biosynthesis. Expression of the WRINKLED1 cDNA under the control of the cauliflower mosaic virus 35S-promoter led to increased seed oil content. Moreover, the ectopic expression of the WRINKLED1 cDNA caused the accumulation of triacylglycerols in developing seedlings. This effect depended upon the presence of glucose in the growth medium or other sugars readily metabolized to glucose. Oil-accumulating seedlings showed aberrant development consistent with a prolonged embryonic state.
Laser dehydrogenation/crystallization of plasma-enhanced chemical vapor deposited amorphous silicon for hybrid thin film transistors (1994)

A low temperature process for laser dehydrogenation and crystallization of hydrogenated amorphous silicon (a-Si:H) has been developed. This process removes hydrogen by laser irradiations at three energy steps. Studies of hydrogen out-diffusion and microstructure show that hydrogen out-diffusion depends strongly on film structure and the laser energy density. Both high quality and low leakage bottom gate polycrystalline silicon and a-Si:H thin film transistors were monolithically fabricated on the same Corning 7059 glass substrate with a maximum process temperature of only 350 °C.
Designing graphene absorption in a multispectral plasmon-enhanced infrared detector (2017)

We have examined graphene absorption in a range of graphene-based infrared devices that combine either monolayer or bilayer graphene with three different gate dielectrics. Electromagnetic simulations show that the optical absorption in graphene in these devices, an important factor in a functional graphene-based detector, is strongly dielectric-dependent. These simulations reveal that plasmonic excitation in graphene can significantly influence the percentage of light absorbed in the entire device, as well as the graphene layer itself, with graphene absorption exceeding 25% in regions where plasmonic excitation occurs. Notably, the dielectric environment of graphene has a dramatic influence on the strength and wavelength range over which the plasmons can be excited, making dielectric choice paramount to final detector tunability and sensitivity.
Metal Injection Molding (MIM) of Magnesium and Its Alloys (2016)

Current research has highlighted that magnesium and its alloys as biodegradable material are highly suitable for biomedical applications. The new material fully degrades into nontoxic elements and offers material properties matching those of human bone tissue. As biomedical implants are rather small and complex in shape, the metal injection molding (MIM) technique seems to be well suited for the near net shape mass production of such parts. Furthermore, MIM of Mg-alloys is of high interest in further technical fields. This study focusses on the performance of MIM-processing of magnesium alloy powders. It includes Mg-specific development of powder blending, feedstock preparation, injection molding, solvent and thermal debinding and final sintering. Even though Mg is a highly oxygen-affine material forming a stable oxide layer on each particle surface, the material can be sintered to nearly dense parts, providing mechanical properties matching those of as cast material. An ultimate tensile strength of 142 MPa, yield strength of 67 MPa, elastic modulus of 40 GPa and 8% elongation at fracture could be achieved using novel organic polymer binders for the feedstock preparation. Thus, first implant demonstrator parts could be successfully produced by the MIM technique.
SocialWatch (2013)

In this paper, we present a framework, SocialWatch, to detect attacker-created accounts and hijacked accounts for online services at a large scale. SocialWatch explores a set of social graph properties that effectively model the overall social activity and connectivity patterns of online users, including degree, PageRank, and social affinity features. These features are hard to mimic and robust to attacker counter strategies. We evaluate SocialWatch using a large, real dataset with more than 682 million users and over 5.75 billion directional relationships. SocialWatch successfully detects 56.85 million attacker-created accounts with a low false detection rate of 0.75% and a low false negative rate of 0.61%. In addition, SocialWatch detects 1.95 million hijacked accounts---among which 1.23 million were not detected previously---with a low false detection rate of 2%. Our work demonstrates the practicality and effectiveness of using large social graphs with billions of edges to detect real attacks.
Performance Assurance Model for HiveQL on Large Data Volume (2015)

Fast growth of application data has led the migration of existing reporting applications to Big data open source technologies such as Hive and Hadoop. Their wide acceptance also considers their use for servicing on-line analytic queries. Ensuring performance assurance of Hive queries will be required to maintain desired level of application performance. Hive query execution time may increase with increase in data size and change in the cluster size. In this paper, we propose a regression based analytical model to predict execution time of Hive query with growth in data volume. A Hive query is executed as DAG of MapReduce (MR) jobs on Hadoop system, this requires predictive model for MR job execution time. We propose multiple linear regression to compute models for various sub phases of MR job execution and build a consolidated model for predicting the execution time of a MR job on large data volume. We introduce ratio of a phase output record size to its input record size and number of map waves as additional sensitive parameters for predicting MR job execution time. The model is validated with MapReduce benchmark and real world financial application for prediction error within 10 %.
Fractional Lambda Switching Principles of Operation and Performance Issues (2004)

This article introduces fractional lambda (λ) switching (FλS) and studies its blocking issues. FλS uses a global common time reference (CTR) for implementing pipeline forwarding (PF) inside the network. A global CTR is conveniently realized with the UTC (coordinated universal time) standard. Resource reservation over an FλS network requires a schedule. As in other scheduling cases, a call may not be accepted, even though there is enough capacity, because the schedule is not available—the call is then considered blocked. This work studies the probability of call blocking as a function of link utilization. The results show that (especially if multiple-wavelength division multiplexing channels are deployed on optical links between fractional λ switches) high-link utilization can be achieved with negligible call blocking, even when the switching fabric is a Banyan network.
Basic data supporting the use of the l-lysine salt of bendazac in cataract. (1983)

Bendazac, as such or in the form of its l-lysine salt, has a protective effect against lens protein denaturation both in vitro and in vivo. In vitro this effect has been documented on the lens proteins of rats, rabbits and pigs by using nephelometry, electrophoresis and electron microscopy. In vivo the protective effect has been observed after treatments ranging in duration from 3 to 14 days depending on the dosage used; the minimal effective dose produced a serum level of 35 micrograms/ml of bendazac. The penetration of the drug into the lens has been shown by both radioassay and HPLC; the lens concentration of bendazac increases with the duration of treatment. The mechanism of the protective action of bendazac against lens protein denaturation is discussed together with the implications of such protective action in the treatment of cataract.
Design and Analysis of Low‐Density Parity‐Check Codes for Applications to Perpendicular Recording Channels (2003)

Abstract In this paper we introduce a novel class of a very high‐rate low‐density parity check codes and analyze their performance in a perpendicular magnetic recording system. Our codes are well‐structured and, unlike random codes, can lend themselves to a very low complexity implementation for high speed applications.
BioSigma Bioleaching Seeds (BBS): A New Technology for Managing Bioleaching Microorganisms (2013)

In Bioleaching, although it is already prove that chalcopyrite can be dissolved by microorganisms, a major task is to do it efficiently in economical terms at industrial scale. BioSigma Bioleaching Seeds (BBS) represents a biotechnological breakthrough for the production of bioleaching solutions on demand with high concentrations of biomining microorganisms. This innovation is mainly a product based on the encapsulation of BioSigma bioleaching microorganisms in a natural matrix of alginate. This technology gives the following operational advantages: 1. High concentration of inoculum. 2. Long period of inoculum storage (more than 1 year). 3. Reduction of volume and costs of transport of bioleaching solutions. 4. Homogeneous mineral inoculation; uniform inoculation of the ore using solid capsules. 5. Protection against toxic elements to retain the viability and activity of the bioleaching solutions. 6. Addition of additives for incorporation of nutrients or other molecules that enhance the activity. 7. Encapsulation of different bioleaching microorganisms producing specific "bioleaching seeds" for each biohydrometallurgical process. All the above advantages make this new technology a very attractive alternative to enhance bioleaching processes at on site operations and overcome stressful conditions for biomining microorganisms.
Synthesis and characterization of multi-arm star-branched polyisobutylenes (1996)

Multi-arm star-branched polyisobutylenes were synthesized by the “arm-first, core-last” method using the 2-chloro-2,4,4-trimethylpentane/pyridine/TiCl4 initiating system and the reactive core-forming comonomers 1,3-diisopropenylbenzene (DIPB) and divinylbenzene (DVB). Star formation was confirmed by RI and UV GPC and static light-scattering analyses. It was determined that DVB was significantly superior to DIPB. Using DVB, star polymers formed more rapidly and contained a much lower amount of residual PIB arms. Increasing the concentration of the reactive comonomer from 1 to 10 times the concentration of chain ends, [CE], increased the efficiency of the star-forming reaction substantially. Modest increases in the fraction of PIB arms incorporated into the star could be obtained by increasing the duration of the star-forming reaction. The timing of addition of the reactive comonomer to the PIB arms seems to be the process parameter most critical to the star development, since early addition at excessively low IB conversion hinders star formation by causing a copolymerization between IB and the core-forming comonomer. Late addition risks loss of a significant fraction of PIB chains due to spontaneous β-proton expulsion. A fully developed multi-arm star-branched PIB was synthesized by utilizing 10:1 [DVB]:[CE], 24 h star-forming reaction time, 14,000 g/mol target arm Mn, and addition of DVB at 99% IB conversion. The resultant star polymer contained only 4% unreacted PIB arms and possessed Mw = 345,000 g/mol by light scattering. The weight-average number of arms per star polymer was calculated to be 23. © 1996 John Wiley & Sons, Inc.
Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation (2005)

A30P and A53T mutations of the presynaptic protein alpha-synuclein are associated with familial forms of Parkinson disease. NMR spectroscopy demonstrates that Parkinsonism-linked mutations greatly perturb specific tertiary interactions essential for the native state of alpha-synuclein. However, alpha-synuclein is not completely unfolded but exhibits structural fluctuations on the time scale of secondary structure formation and loses its native conformation gradually when protein stability decreases. The redistribution of the ensemble of alpha-synuclein conformers may underlie toxic gain-of-function by fostering self-association and altered binding affinity to ligands and receptors.
Printed polyaniline-modified interdigitated electrodes for detection and quantification of ammonia in breath (2011)

A range of pathological conditions can lead to elevated blood ammonia and urea nitrogen levels. These include kidney and liver dysfunction and urea cycle defects. These conditions result in severe reduction in quality and quantity of life. Blood nitrogen levels are controlled by dialysis and monitored using invasive blood tests. Blood nitrogen levels have the potential to be monitored non-invasively in by measuring ammonia in breath. We have developed a device for monitoring human breath ammonia levels.
Identification of novel 1,4‐benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration (2010)

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease and conditions such as ischemic stroke affect millions of individuals annually and exert an enormous financial burden on society. A hallmark of these conditions is the abnormal loss of neurons. Currently, there are no effective strategies to prevent neuronal death in these pathologies. We report that several 2-arylidine and 2-hetarylidin derivatives of the 1,4-benzoxazines class of compounds are highly protective in tissue culture models of neurodegeneration. Results obtained using pharmcalogical inhibitors indicate that neuroprotection by these compounds does not involve the Raf-MEK-ERK or PI-3 kinase-Akt signaling pathways nor other survival-promoting molecules such as protein kinase A (PKA), calcium calmodulin kinase A (CaMK), and histone deacetylases (HDACs). We tested one of these compounds, (Z)-6-amino-2-(3',5'-dibromo-4'-hydroxybenzylidene)-2H-benzo[b][1,4]oxazin-3(4H)-one, designated as HSB-13, in the 3-nitropropionic acid (3-NP)-induced mouse model of Huntington's disease. HSB-13 reduced striatal degeneration and improved behavioral performance in mice administered with 3-NP. Furthermore, HSB-13 was protective in a Drosophila model of amyloid precursor protein (APP) toxicity. To understand how HSB-13 and other 1,4-benzoxazines protect neurons, we performed kinase profiling analyses. These analyses showed that HSB-13 inhibits GSK3, p38 MAPK, and cyclin-dependent kinases (CDKs). In comparison, another compound, called ASK-2a, that protects cerebellar granule neurons against low-potassium-induced death inhibits GSK3 and p38 MAPK but not CDKs. Despite its structural similarity to HSB-13, however, ASK-2a is incapable of protecting cortical neurons and HT22 cells against homocysteic acid (HCA)-induced or Abeta toxicity, suggesting that protection against HCA and Abeta depends on CDK inhibition. Compounds described in this study represent a novel therapeutic tool in the treatment of neurodegenerative diseases.