gebhart/patrepeval huggingface dataset:
Particles with Coordinated Patches or Windows from Oil-in-Water Emulsions (2007)

In this paper, we demonstrated a unique and simple method for fabricating colloidal particles of complex structures using oil-in-water emulsion droplets as confined geometries. A variety of structural motifs were produced using binary colloids of microspheres of polystyrene (PS) or silica and nanosized particles as the second component. When PS or silica microspheres and PS macromolecules were dispersed in oil-in-water emulsion droplets, particles with well-coordinated patches were obtained because the PS macromolecules partially covered the microsphere clusters. When silica or gold nanoparticles were dispersed together with the PS microspheres in oil-in-water emulsion droplets instead of PS macromolecules, composite particles with patches were obtained. In this case, silica or gold shell structures with well-coordinated windows were produced by selectively removing the large PS microspheres from the organic−inorganic composite clusters.
Hybrid digital-analog (HDA) joint source-channel codes for broadcasting and robust communications (2002)

We consider the problem of transmitting a band-limited Gaussian source on an additive band-limited Gaussian noise channel. The well-known "threshold effect" dictates that the more powerful a code is, the more sensitive it is to the exact knowledge of the channel noise. A code is said to be robust if it is asymptotically optimal for a wide range of channel noise. Thus, robust codes have a "graceful degradation" characteristic and are free of the threshold effect. It is demonstrated that robust codes exist whenever the source and channel bandwidths are equal. In the unequal-bandwidth case, a collection of nearly robust joint source-channel codes is constructed using a hybrid digital-analog (HDA) coding technique. For designing nearly robust codes, a matched tandem code whose channel encoder's output is partially/fully matched to its input is proposed and the existence of an asymptotically optimal matched tandem code is shown. The nearly robust codes achieve the Shannon limit (theoretically optimum distortion) and have a less severe threshold effect. Finally, for the case of two different noise conditions, the distortion regions of these codes are determined.
Changes to Levodopa Daily Dose in Parkinson’s Disease (PD) Patients with Dyskinesia While on GocovriTM (Amantadine) Extended Release Capsules: a Two-Year Phase 3 Open Label Study Analysis (P4.7-010) (2019)

Characterize the safety and efficacy of 274 mg Gocovri in patients who adjusted their levodopa daily dose prior to completion of the two-year open label study.
Zinc Gluconate Lozenges for Treating the Common Cold (1997)

Letters1 May 1997Zinc Gluconate Lozenges for Treating the Common ColdMichael L. Macknin, MD, Sherif B. Mossad, MD, and Sharon V. Medendorp, MPHMichael L. Macknin, MDCleveland Clinic Foundation, Cleveland, OH 44195Search for more papers by this author, Sherif B. Mossad, MDCleveland Clinic Foundation, Cleveland, OH 44195Search for more papers by this author, and Sharon V. Medendorp, MPHCleveland Clinic Foundation, Cleveland, OH 44195Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We do not agree with Farr and colleagues that the placebo used in our study resulted in biased results favoring beneficial treatment effects of the zinc lozenges. Patients receiving zinc lozenges who reported no side effects of the medication before the end of the study reported a duration of symptoms similar to that in persons with side effects. The number of placebo and zinc recipients who believed that their medication had helped alleviate their cold symptoms did not significantly differ. No clear pattern of movement was seen regarding a patient's guesses about which medication he or she was ...References1. Korant BD, Butterworth BE. Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides. J Virol. 1976; 18:298-306. Google Scholar2. Salas M, Kirchner H. Induction of interferon-γ in human leukocyte cultures stimulated by Zn2+. Clin Immunol Immunopathol. 1987; 45:139-42. Google Scholar3. Novick SG, Godfrey JC, Godfrey NJ, Wlder HR. How does zinc modify the common cold? Clinical observations and implications regarding mechanism of action. Med Hypotheses. 1996; 46:295-302. Google Scholar4. Pasternak CA. A novel form of host defence: membrane protection by Ca2+ and Zn2+. Biosci Rep. 1987; 7:81-91. Google Scholar5. Kelly RW, Abel MH. Copper and zinc inhibit the metabolism of prostaglandin by the human uterus. Biol Reprod. 1983; 28:883-9. Google Scholar Author, Article, and Disclosure InformationAuthors: Michael L. Macknin, MD; Sherif B. Mossad, MD; Sharon V. Medendorp, MPHAffiliations: Cleveland Clinic Foundation, Cleveland, OH 44195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1997Volume 126, Issue 9Page: 739KeywordsCell membranesCommon coldEpitheliumInterferonsNursesZinc ePublished: 15 August 2000 Issue Published: 1 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Regulation of corticosteroid receptors in patients with anorexia nervosa and Cushing's syndrome (1998)

We have studied 16 patients with anorexia nervosa (11 with a stabilised weight loss and 5 in the weight-losing phase), 11 healthy controls, and 10 patients with Cushing's syndrome, by measuring plasma cortisol (by enzyme-immunoassay), ACTH (by RIA), corticosteroid (Type I-mineralocorticoid and Type II-glucocorticoid) receptors in mononuclear leukocytes (by radio-receptor assay), and lymphocyte subpopulations (by cytofluorimetry). In anorexic patients with a stabilised weight loss and in Cushing's syndrome the mean value of both Type I and Type II corticosteroid receptors in mononuclear leukocytes was significantly lower than in controls. The correlation between Type II receptors and plasma cortisol was inverse in stabilised anorexia nervosa and in Cushing's syndrome, and direct in healthy controls. Anorexic patients in the weight-losing phase showed a significant increase in plasma cortisol levels and a normal number of Type II receptors. From these results we hypothesise that in anorexia nervosa there is a progression from an increase in plasma cortisol in the weight-losing phase, to a concomitant decrease in Type II receptors when the disease is stabilised.
Smart signal processing for an evolving electric grid (2015)

Electric grids are interconnected complex systems consisting of generation, transmission, distribution, and active loads, recently called prosumers as they produce and consume electric energy. Additionally, these encompass a vast array of equipment such as machines, power transformers, capacitor banks, power electronic devices, motors, etc. that are continuously evolving in their demand characteristics. Given these conditions, signal processing is becoming an essential assessment tool to enable the engineer and researcher to understand, plan, design, and operate the complex and smart electronic grid of the future. This paper focuses on recent developments associated with signal processing applied to power system analysis in terms of characterization and diagnostics. The following techniques are reviewed and their characteristics and applications discussed: active power system monitoring, sparse representation of power system signal, real-time resampling, and time-frequency (i.e., wavelets) applied to power fluctuations.
Performance Studies and Review of Millimeter Wave MIMO Beamforming at 60 GHz (2015)

Abstract Millimeter wave systems offer high date rate due to huge bandwidth but suffers from poor link budget. This is due to the blockage of the millimeter wave signal by the obstacles of size comparable to that of the wavelength of the signal. Various analysis in improving the signal strength is reported. One of them suggests use of directional antenna which guarantees signal delivery if line of sight communication between the transmitter and receiver exists. The other alternative scheme is Multi Input Multi Output (MIMO) beamforming that uses the channel statistics to steer the beam thereby improving the multiplexing gain and beamforming gain. In this paper, extensive research work carried out by us in MMW MIMO at 60 GHz covering aspects related to MIMO fixed-beam, adaptive beam and multibeam beamformers addressing line-of-sight and non-line-of-sight channel for MMW 60 GHz system is reviewed.
13.8 A 5.8GHz RF-powered transceiver with a 113&#x03BC;W 32-QAM transmitter employing the IF-based quadrature backscattering technique (2015)

Although it is obvious that using a trillion sensor nodes for wireless sensor network (WSN) application would deeply exacerbate the spectral congestion issue, RF-powered sensor nodes [1,2] still support only low spectral-efficiency modulation such as OOK. State-of-the-art standard-compliant RF transceivers for low-power applications have been achieving multilevel modulation such as n/8 D8PSK [3], but their power consumption is as large as 1mW without PA even in the 400MHz band because of the large power consumption of the RF synthesizer, which is required to provide high-frequency accuracy and low phase noise for multilevel modulation. This work presents an IF-based quadrature backscattering technique, enabling n-PSK and n-QAM without an RF PLL. The presented technique exploits the passive RFID technologies, but can realize both amplitude and phase modulation concurrently. Our TX in 65nm Si CMOS achieves spectral efficiency of 3.3b/s/Hz with 32QAM while consuming 113uW with a 0.6V power supply in our measurements, which has 6.6 times better spectral efficiency than previous RF-powered wireless transceivers [1,2]. The prototype RF-powered sensor node with our transceiver including the TX, RX, and an RF energy harvester (RF-EH), succeeds in a wireless temperature-sensing application.
2.8 Gbit/s optical soliton transmission employing all laser diodes (1990)

2.8 Gbit/s optical soliton transmission is successfully demonstrated using a gain-switched 1.55 μm distributed feedback laser diode and a Ti : LiNbO3 intensity modulator. An Er3+-doped fibre amplifier and a Raman amplifier, both pumped by 1.47 μm laser diodes, are employed to achieve intense optical pulses and fibre-loss compensation, respectively.
Dpp receptors are autonomously required for cell proliferation in the entire developing <i>Drosophila</i> wing (1996)

The mammalian growth factor TGFbeta negatively regulates cell proliferation in various systems. Here we provide evidence that another TGFbeta superfamily member, Drosophila Decapentaplegic (Dpp), stimulates cell proliferation. In the developing wing blade, somatic clones lacking the Dpp receptors Punt or Thick veins (Tkv), or lacking Schnurri, a transcription factor involved in Dpp signal interpretation, fail to grow when induced early in larval development. Furthermore the spatial requirement for these signaling components indicates that Dpp has to travel several cell diameters from its source in order to reach all cells that require its signal. The requirement for Tkv also depends on the distance of cells from the source of the Dpp signal. We propose that Dpp can act at a distance to positively control cell proliferation.
Secure and Efficient Content Distribution in Crowdsourced Vehicular Content-Centric Networking (2017)

In future intelligent transportation systems, a large amount of content needs to be efficiently and securely exchanged between vehicles and roadside units via vehicular networks to improve the driving and traveling experience. To solve the challenges caused by poor-quality wireless links and the mobility of vehicles, vehicular content-centric networking (VCCN) emerges as a promising paradigm, which has a better content distribution efficiency, mobility, and security via named data and in-networking caching compared with an IP-based network. However, providing a high-quality experience for content distribution in VCCN is challenging due to the dynamic network topologies, varying wireless channel conditions, and vehicle user privacy. In this paper, we propose a novel crowdsourced VCCN framework for secure and efficient content distribution. This framework enables the nearby vehicles to crowdsource their caching resources and radio links for cooperative content distribution. We formulate the problem as the maximization of all users' payoff and propose an online scheduling method to solve this solution. Furthermore, we adopt identity-based proxy reencryption and named function networking to secure the process of content distribution. The simulation results show that our proposals improve the performance of VCCN in terms of average requester utility compared with original CCN forwarding strategies.
Notions of Destiny in Women's Self-Construction (1998)

What can women become? How is their becoming fashioned? What forces affect it? What sense do they make of their becoming? In this article the author aims to raise issues which pertain to women and their conceptions of destiny, and to consider these in the light of recent feminist analyses. Three issues are discussed: the ‘good woman’, or the impact of gendered norms and expectations upon women's destinies; women's self-construction and the possibility of women envisioning or creating their own destinies; and the becoming of the woman-subject, the desire of women collectively to accomplish their subjectivity as women. The themes of determinism and women's differences are also considered.
Expanding Trace Buffer Observation Window for In-System Silicon Debug through Selective Capture (2008)

Trace buffers are commonly used to capture data during in-system silicon debug. This paper exploits the fact that it is not necessary to capture error-free data in the trace buffer since that information is obtainable from simulation. The trace buffer need only capture data during clock cycles in which errors are present. A three pass methodology is proposed. During the first pass, the rough error rate is measured, in the second pass, a set of suspect clock cycles where errors may be present is determined, and then in the third pass, the trace buffer captures only during the suspect clock cycles. In this manner, the effective observation window of the trace buffer can be expanded significantly, by up to orders of magnitude. This greatly increases the effectiveness of a given size trace buffer and can rapidly speed up the debug process. The suspect clock cycles are determined through a two dimensional (2-D) compaction technique using a combination of multiple-input signature register (MISR) signatures and cycling register signatures. By intersecting the signatures, the proposed 2-D compaction technique generates a small set of remaining suspect clock cycles for which the trace buffer needs to capture data. Experimental results indicate very significant increases in the effective observation window for a trace buffer can be obtained.
THE ROLE OF A LAX POSTERIOR VAGINAL FORNIX IN THE CAUSATION OF STRESS AND URGENCY SYMPTOMS: A PRELIMINARY REPORT (1990)

Ten patients are presented with symptoms of urinary stress and/or urgency. Eight were cured by approximation of the uterosacral ligaments. This supports the contention of the Integral Theory of Female Urinary Incontinence that a loosely tethered supralevator vagina may be an important element in urinary incontinence, especially following hysterectomy.
A study on an AC active load simulator (2003)

An AC active load simulator is realized and tested which can simulate an AC load impedance excited by an AC voltage source. An interface circuit is designed to compute the simulated current waveform for the load-driver circuit according to the specified impedance network and the measured source frequency and voltage amplitude. Both inductive and capacitive loads can be simulated by adjusting the phase difference between the voltage and current waveforms. A software feedback control approach is employed to adjust the current amplitude for the purpose of maintaining the impedance value constant regardless of the variation of the source voltage amplitude.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
176-65: Long-term reverse remodeling of cardiac resynchronization therapy with MultiPoint Pacing using noninvasive hemodynamics-guided programming (2016)

Introduction: Cardiac resynchronization therapy (CRT) with multipoint left ventricular (LV) pacing (MultiPoint™ Pacing [MPP], St. Jude Medical) improves acute hemodynamics and chronic outcomes compared to conventional biventricular pacing (BiV), although questions persist on MPP programming. In this multi-center pilot study, we evaluated the feasibility of using noninvasive systolic blood pressure (SBP) to guide MPP programming, and assessed the chronic, 6-month response. Methods: Patients (pts) implanted with a CRT-D device (Quadra Assura MP™ and Quartet™ LV lead, St Jude Medical) underwent noninvasive hemodynamic assessment using finger arterial pressure measurements (Finometer MIDI, Finapres Medical Systems) prior to discharge. The pacing protocol included atrial pacing only, 4 simultaneous BiV configurations with LV pacing at each of the 4 LV electrodes, and 8 MPP configurations. Each pacing configuration was repeated 4 times, alternating with a BiV reference, to calculate the SBP difference relative to reference (ΔSBP). Each pt was programmed to the CRT configuration with the greatest ΔSBP. Pts were followed for 6 months, with echocardiographic measurements analyzed by a core lab. CRT response was defined as >15% decrease in LV end-systolic volume (ΔESV) at 6 months post-implant. Results: Forty-two pts (71% male, EF 30.3 ± 7.5%, QRS duration 161 ± 19 ms, 26% ischemic) were enrolled in 4 European centers. Relative to atrial pacing only, the best BiV and best MPP configurations produced significant SBP elevations of 3.1 ± 4.2 (p < 0.01) and 4.1 ± 4.1 mmHg (p < 0.01), respectively (MPP vs BiV, p < 0.01). Greater SBP elevations were associated with the best MPP compared to the best BiV configurations in 29/37 (78%) of pts completing the pacing protocol. Of MPP-programmed pts completing the 6 month follow-up, 23/27 (85%) were classified as CRT responders (ΔESV = 31 ± 20%). Conclusion: Acute noninvasive hemodynamics after CRT implant commonly favored MPP over BiV programming. MPP programming guided by noninvasive hemodynamics, specifically systolic blood pressure, resulted in positive LV structural remodeling.
NPENAS: Neural Predictor Guided Evolution for Neural Architecture Search (2020)

Neural architecture search (NAS) is a promising method for automatically design neural architectures. NAS adopts a search strategy to explore the predefined search space to find outstanding performance architecture with the minimum searching costs. Bayesian optimization and evolutionary algorithms are two commonly used search strategies, but they suffer from computationally expensive, challenge to implement or inefficient exploration ability. In this paper, we propose a neural predictor guided evolutionary algorithm to enhance the exploration ability of EA for NAS (NPENAS) and design two kinds of neural predictors. The first predictor is defined from Bayesian optimization and we propose a graph-based uncertainty estimation network as a surrogate model that is easy to implement and computationally efficient. The second predictor is a graph-based neural network that directly outputs the performance prediction of the input neural architecture. The NPENAS using the two neural predictors are denoted as NPENAS-BO and NPENAS-NP respectively. In addition, we introduce a new random architecture sampling method to overcome the drawbacks of the existing sampling method. Extensive experiments demonstrate the superiority of NPENAS. Quantitative results on three NAS search spaces indicate that both NPENAS-BO and NPENAS-NP outperform most existing NAS algorithms, with NPENAS-BO achieving state-of-the-art performance on NASBench-201 and NPENAS-NP on NASBench-101 and DARTS, respectively.
P53 Oncogene Mutations in Human Prostate Cancer Specimens (1994)

Eighty-five prostate cancer specimens from prostate resections were analyzed for the presence of p53 gene mutations by immunohistochemical staining for P53 protein. DNA from thirty-four of these samples was also analyzed for mutations in exons 5-8 by single-strand chain polymorphism (SSCP) analysis. One sample had P53 staining by immunohistochemistry, one sample was positive for a p53 mutation by SSCP, and one sample was positive by both techniques. Mutations in the two samples that were positive by SSCP were confirmed by nucleotide sequencing. In a separate study of ten lymph nodes that contained prostate cancer metastases, one had detectable P53 protein by immunohistochemical staining. Therefore, p53 mutations appear to be low frequency events in primary prostate cancer.
Model checking of statecharts using automatic white box test generation (2005)

This paper describes a model checking technique and tool for UML statecharts based on automatic white box test-generation combined with automatic run-time monitoring of statechart assertions. The white box test generator is an automatically generated JUnit TestCase, which generates sequences of events, conditions, and input data for the system under test (SUT). It generates test sequences while observing the SUT's state, knowing the input events, conditions, and data objects that potentially affect the SUT's next state. The white box tester then chooses one of those events, conditions, and data objects, and fires the SUT, which in turn fires an embedded assertion for run-time monitoring. This combination of white box testing with assertion monitoring constitutes automatic model checking. The white-box test-generator is also specification based in that the white box can be specified to be requirement assertions
4-(Phenylsulfonyl)piperidines:  Novel, Selective, and Bioavailable 5-HT<sub>2A</sub>Receptor Antagonists (2001)

On the basis of a spirocyclic ether screening lead, a series of acyclic sulfones have been identified as high-affinity, selective 5-HT(2A) receptor antagonists. Bioavailability lacking in the parent, 1-(2-(2,4-difluorophenyl)ethyl)-4-(phenylsulfonyl)piperidine (12), was introduced by using stability toward rat liver microsomes as a predictor of bioavailability. By this means, the 4-cyano- and 4-carboxamidophenylsulfonyl derivatives 26 and 31 were identified as orally bioavailable, brain-penetrant analogues suitable for evaluation in animal models. Bioavailability was also attainable by N substitution leading to the N-phenacyl derivative 35. IKr activity detected through counterscreening was reduced to insignificant levels in vivo with the latter compound.