gebhart/patrepeval huggingface dataset:
Nonuniform acquisition design for foothill environment (2017)

The main challenge of seismic exploration in foothill environment origins from the complex surface and rugged topography. Seismic data acquired in such areas often suffers from difficulties to acquire data in regular distributed source and receiver locations. To relax the traditional requirement for acquiring data from well sampled regular grids, we studied irregular pattern acquisition design and data reconstruction based on compressive sensing which could help to reconstruct the data at unreachable locations especially for foothill area. In order to demonstrate the feasibility of irregular acquisition for strong topography area, a synthetic example generated from elastic modeling using SEAM foothills model is used to analysis the data reconstruction benefit from irregularly sampled seismic data compare to regularly sampled seismic data. A field data with un-uniform receiver locations is acquired to verify the reconstruction capability. The preliminary results shows the benefit of reconstruction. Presentation Date: Wednesday, September 27, 2017 Start Time: 9:20 AM Location: 371F Presentation Type: ORAL
Anti-Reflective and Waterproof Hard Coating for High Power Laser Optical Elements (2006)

A hard coating method of single crystalline porous silica film is widely used for high power laser optical elements in the air. However, there is no protective hard coating method for the elements to survive high power laser irradiance while in the water. We, thus, developed a new method for a waterproof coating with photo‐oxidation of silicone oil. The silicone oil was spin‐coated onto the surface of optical elements, and then irradiated with a xenon excimer lamp in the air. In this treatment, a protective coating for plastic lenses, mirrors, and nonlinear optical crystals, which are highly deliquescent, was developed by taking advantage of the phenomenon in which organic silicone oil is transformed to inorganic amorphous glass by a process of photo‐oxidation. This technique has enabled an optical thin coating film to transmit ultraviolet rays of wavelengths under 200 nm and possess the characteristics of homogeneity, high density, resistance to environment, anti‐reflectiveness, resistance to water, and Mohs’ scale of 5, which is comparable to apatite. This allows us to cool a slab laser head and use as a mirror for underwater laser welding.
Effect of blasts on subject-specific computational models of skin and bone sections at various locations on the human body (2015)

Blast injuries are very common among soldiers deployed in politically unstable regions such as Afghanistan and Iraq, and also in a battle field anywhere in the world. Understanding the mechanics of interaction of blasts with the skin and bone at various parts of the human body is the key to designing effective personal protective equipment (PPE's) which can mitigate blast impacts. In the current work, subject-specific 3D computational models of the skin (with the three layers namely the epidermis, dermis and the hypodermis (muscles)) and bone sections from various parts of the human body (such as the elbow, finger, wrist, cheek bone, forehead, shin etc.) have been developed to study the effect of blast loading. Non-linear material properties have been adopted for the skin and stress impulses at the different skin layers and bone sections are estimated. To date, such an extensive study on the effect of blast loading on the human skin and bone has not been attempted. The results of this study would be indispensable for medical practitioners to understand the effect of blast trauma and plan effective post-traumatic surgical strategies, and also for developing better PPE designs for the military in the future.
The Family of Crumbs Genes and Human Disease (2016)

The family of vertebrate Crumbs proteins, homologous to <i>Drosophila</i> Crumbs (Crb), share large extracellular domains with epidermal growth factor-like repeats and laminin-globular domains, a single transmembrane domain, and a short intracellular C-terminus containing a single membrane proximal 4.1/ezrin/radixin/moesin-binding domain and PSD-95/Discs large/ZO-1-binding motifs. There are 3 Crb genes in humans - Crumbs homolog-1 <i>(CRB1)</i>, Crumbs homolog-2 <i>(CRB2)</i>, and Crumbs homolog-3 <i>(CRB3)</i>. Bilallelic loss-of-function mutations in <i>CRB1</i> cause visual impairment, with Leber's congenital amaurosis and retinitis pigmentosa, whereas <i>CRB2</i> mutations are associated with raised maternal serum and amniotic fluid alpha feto-protein levels, ventriculomegaly/hydrocephalus, and renal disease, ranging from focal segmental glomerulosclerosis to congenital Finnish nephrosis. <i>CRB3</i> has not yet been associated with human disease. In this review, we summarize the phenotypic findings associated with deleterious sequence variants in <i>CRB1</i> and <i>CRB2</i>. We discuss the mutational spectrum, animal models of loss of function for both genes and speculate on the likely mechanisms of disease.
Iron(III) Bound by Hydrosulfide Anion Ligands: NO-Promoted Stabilization of the [Fe<sup>III</sup>–SH] Motif (2014)

Spontaneous transformation of the thermally stable [HS](-)-bound {Fe(NO)2}(9) dinitrosyl iron complex (DNIC) [(HS)2Fe(NO)2](-) (1) into [(NO)2Fe(μ-S)]2(2-) (Roussin's red salt (RRS)) along with release of H2S, probed by NBD-SCN (NBD = nitrobenzofurazan), was observed when DNIC 1 was dissolved in water at ambient temperature. The reversible transformation of RRS into DNIC 1 (RRS → DNIC 1) in the presence of H2S was demonstrated. In contrast, the thermally unstable hydrosulfide-containing mononitrosyl iron complex (MNIC) [(HS)3Fe(III)(NO)](-) (3) and [Fe(III)(SH)4](-) (5) in THF/DMF spontaneously dimerized into the first structurally characterized Fe(III)-hydrosulfide complexes [(NO)(SH)Fe(μ-S)]2(2-) (4) with two {Fe(NO)}(7) motifs antiferromagnetically coupled and [(SH)2Fe(μ-S)]2(2-) (6) resulting from two Fe(III) (S = 5/2) centers antiferromagnetically coupled to yield an S = 0 ground state with thermal occupancy of higher spin states, respectively. That is, the greater the number of NO ligands bound to [2Fe2S], the larger the antiferromagnetic coupling constant. On the basis of DFT computation and the experimental (and calculated) reduction potential (E1/2) of complexes 1, 3, and 5, the NO-coordinate ligand(s) of complexes 1 and 3 serves as the stronger electron-donating ligand, compared to thiolate, to reduce the effective nuclear charge (Zeff) of the iron center and prevent DNIC 1 from dimerization in an organic solvent (MeCN).
A digitally-assisted electrothermal frequency-locked loop (2009)

A digitally-assisted electrothermal frequency-locked loop (FLL) is presented, whose output frequency is determined by the temperature-dependent thermal diffusivity of bulk silicon. In contrast to previous work, its noise bandwidth is defined by a digital, rather than an analog, filter. This obviates the need for external capacitors, thus enabling full CMOS integration. Without trimming, an implementation in a 0.7 mum CMOS process achieves an output frequency spread of about plusmn0.3% (3sigma) from -55degC to 125degC. This corresponds to a temperature sensing inaccuracy of about plusmn0.7degC (3sigma).
Smart Cities Built on Resilient Cloud Computing and Secure Internet of Things (2013)

Cloud Computing and Internet of Things (IoT) are currently two of the most popular ICT paradigms that are expected to shape the next era of computing. The convergence between cloud computing and IoT has become a hot topic over the last few years because of the benefits that IoT could have from the distributed nature of cloud computing infrastructures. This paper proposes a new platform for using cloud computing capacities for provision and support of ubiquitous connectivity and real-time applications and services for smart cities' needs. We present a framework for data procured from highly distributed, heterogeneous, decentralized, real and virtual devices (sensors, actuators, smart devices) that can be automatically managed, analyzed and controlled by distributed cloud-based services.
Melanosome Capping of Keratinocytes in Pigmented Reconstructed Epidermis – Effect of Ultraviolet Radiation and 3‐Isobutyl‐1‐Methyl‐Xanthine on Melanogenesis (2000)

Reconstructed pigmented epidermis was established by co-seeding autologous melanocytes and keratinocytes onto a dermal substrate and culturing for up to 6 weeks at the air-liquid interface. Inspection of the tissue architecture revealed that melanocytes are regularly interspersed only in the basal layer and transfer melanosomes to the keratinocytes. We report for the first time, the in vitro formation of supranuclear melanin caps above the keratinocyte nuclei. The formation and abundance of these melanin caps could be enhanced by pigment modifiers such as ultraviolet light and 3-isobutyl-1-methyl-xanthine (IBMX). In untreated cultures, the capping was observed in the spinous layers after 6 weeks of culture, whereas after irradiation or supplementation of the culture medium with IBMX, the capping occurred already in the basal layer 2 weeks after initiation of the stimulus. In this study, we show that IBMX and ultraviolet irradiation stimulate pigmentation via different mechanisms. After supplementation of the culture medium with IBMX the increase in pigmentation was entirely due to the increase in melanocyte activity as observed by increased dendrite formation, melanin production and transport to the keratinocytes and was not due to an increase in melanocyte proliferation. In contrast, after UV irradiation, the increase in pigmentation was also accompanied with an increase in melanocyte proliferation as well as an increase in melanocyte activity. In conclusion, we describe the establishment of pigmented reconstructed epidermis with autologous keratinocytes and melanocytes that can be kept in culture for a period of at least 6 weeks. The complete program of melanogenesis occurs: melanosome synthesis, melanosome transport to keratinocytes, supranuclear capping of keratinocyte nuclei and tanning of the epidermis. This enables sustained application of pigment stimulators over a prolonged period of time and also repeated application of pigment stimulators to be studied.
Glycosidic conjugates of aliphatic alcohols from apple fruit (Malus sylvestris Mill cult. Jonathan) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlycosidic conjugates of aliphatic alcohols from apple fruit (Malus sylvestris Mill cult. Jonathan)Wilfried Schwab and Peter SchreierCite this: J. Agric. Food Chem. 1990, 38, 3, 757–763Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/jf00093a037https://doi.org/10.1021/jf00093a037research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Site-directed mutagenesis of rat liver <i>S</i>-adenosylmethionine synthetase. Identification of a cysteine residue critical for the oligomeric state (1996)

We have examined the functional importance of the cysteine residues of rat liver S-adenosylmethionine synthetase. For this purpose the ten cysteine residues of the molecule were changed to serines by site-directed mutagenesis. Ten recombinant enzyme mutants were obtained by using a bacterial expression system. The same level of expression was obtained for the wild type and mutants, but the ratio of S-adenosylmethionine synthetase between soluble and insoluble fractions differed for some of the mutant forms. The immunoreactivity against an anti-(rat liver S-adenosylmethionine synthetase) antibody was equivalent in all the cases. Effects on S-adenosylmethionine synthetase activities were also measured. Mutants C57S, C69S, C105S and C121S showed decreased relative specific activity of 68, 85, 63 and 29%, respectively, compared with wild-type, whereas C312S resulted in an increase of 1.6-fold. Separation of tetramer and dimer forms for wild type and mutants was carried out by using phenyl-Sepharose columns. The dimer/tetramer ratio was calculated based on the activity and on the protein level estimated by immunoblotting. No monomeric forms of the enzyme were detected in any case. Comparison of dimer/tetramer ratios indicates the importance of cysteine-69 (dimer/tetramer protein ratio of 88 versus 10.2 in the wild type) in maintaining the oligomeric state of rat liver S-adenosylmethionine synthetase. Moreover, all the mutations carried out of cysteine residues between cysteine-35 and cysteine-105 altered the ratio between oligomeric forms.
Preparation and Characterization of Light-Switchable Polymer Networks Attached to Solid Substrates (2013)

Surface-attached polymer networks that carry light-responsive nitrospiropyran groups in a hydrophilic PDMAA matrix were prepared on planar silicon and glass surfaces and were characterized with respect to their switching behavior under the influence of an external light trigger. Functional polymers bearing light-responsive units as well as photo-cross-linkable benzophenone groups were first synthesized using free radical copolymerization. The number of spiropyran groups in the copolymer was controlled by adjusting the concentration of the respective monomer in the copolymerization feed. The polymer films were prepared by spin-coating the functional polymers from solution and by ultraviolet light (UV)-induced cross-linking utilizing benzophenone photochemistry. On substrates with immobilized benzophenone groups, the complete polymer network is linked to the surface. The dry thickness of the films can be controlled over a wide range from a few nanometers up to more than 1 μm. The integration of such light-switchable organic moieties into a surface-attached polymer network allows one to increase the overall number of light-responsive groups per surface area by adjusting the amount of surface-attached polymer networks. The spiropyran's function in dry (solvent-free) and swollen polymer films can be reversibly switched by UV and visible irradiation. In addition, the switching in water is faster than in the dry state. Therefore, implementing light-responsive spiropyran functions in polymer films linked to solid surfaces could allow for switching of the chemical and optical surface properties in a fast and spatially controlled fashion.
Globalization of Intelligent Network Services (1992)

Many multinational companies have successfully used intelligent network services within a country to control costs and, at the same time, enhance network management control and feature functionality. As intelligent network services continue to evolve and prove their value on a national level, and as customers expand internationally, there is a natural demand to extend these telecommunications capabilities globally. This paper highlights issues that must be considered as we design and implement global intelligent network services. It also includes either a high-level or a conceptual view of four potential global intelligent network services: global virtual private network, global credit card validation, global Freephone, and global switched digital data.
Sporulation and the Production of Serine Protease and Cephamycin C by <i>Streptomyces lactamdurans</i> (1979)

Streptomyces lactamdurans, producer of the antibiotic cephamycin C, excretes at least two proteases. Physiological studies indicate that antibiotic synthesis and serine protease formation are coordinately regulated. Both are produced only after culture growth ends, and they appear with essentially identical kinetics. In addition, strains which produce superior levels of cephamycin C form equally superior levels of the serine protease. Genetic evidence reveals that the syntheses of the antibiotic and serine proteases are associated with sporulation. Mutants which fail to produce aerial hyphae (bald mutants) also fail to synthesize the antibiotic and serine proteases.
Silicon carbide power electronic module packaging (2015)

Wide bandgap semiconductors such as gallium nitride (GaN) and silicon carbide (SiC) offer exciting opportunities in enhancing the performance of power electronic systems in term of improved efficiency as well as higher temperature operation. Both silicon carbide and gallium nitride power semiconductor devices offer a higher voltage handling capability over their silicon power semiconductor counterparts. In this paper, the design and packaging issues for SiC power electronic modules are discussed. Several SiC devices are usually connected in parallel to increase its current handling capability in power electronic module packaging. The paralleling of these SiC devices creates unbalanced parasitic inductances which affect the dynamic switching performance for these paralleled devices. Each of the paralleled SiC devices could have different initial peak currents due to their different parasitic inductances within the module. Moreover, their fast dv/dt of the drain voltages as well as the high di/dt of the drain currents can cause spurious switching behaviors in some of the paralleled SiC devices in the power module. Layout techniques can be used to mitigate these spurious switching behaviors. However, module construction architectures and as well as module package construction are required to further mitigate these parasitic inductances. One of the many advantages of the SiC power devices is high voltage handling capability. High voltage operation of the power electronic module requires careful reduction of electric field intensification within the device as well as the module. Encapsulations with the desired dielectric breakdown strength as well as temperature performance must be applied on top of these devices to prevent premature voltage breakdown. One of the salient features of the SiC power electronic modules is high temperature operation of greater than 175°C. For high temperature operations, proper die attach must be utilized. Nano silver sintering and transient liquid phase bonding are two high temperature die attachment techniques. For high temperature operation, reliability testing for these SiC power electronic modules must be carefully considered since there is no existing international standard for reliability testing for these high-temperature power electronic modules.
Energy and Economic Sustainability of a Trigeneration Solar System Using Radiative Cooling in Mediterranean Climate (2021)

The spreading of nearly zero-energy buildings in Mediterranean climate can be supported by the suitable coupling of traditional solar heating, photovoltaics and radiative cooling. The latter is a well-known passive cooling technique, but it is not so commonly used due to low power density and long payback periods. In this study, the energy performance of a system converting solar energy into electricity and heat during the daytime and offering cooling energy at night is assessed on the basis of a validated model of a trifunctional photovoltaic–thermal–radiative cooling module. The key energy, CO2 emission and economic performance indicators were analyzed by varying the main parameters of the system, such as the spectral emissivity of the selective absorber plate and cover and thermal insulation thickness. The annual performance analysis is performed by a transient simulation model for a typical residential building and two different climates of the Mediterranean area (Trapani and Milano). For both climates, glass-PVT–RC is the best solution in terms of both overall efficiency (electric + thermal) and cooling energy capacity, even better with a thicker insulation layer; the annual electrical, heat and cooling gains of this system are 1676, 10,238 and 3200 kWh for Trapani, correspondingly (1272, 9740 and 4234 kWh for Milano, respectively). The typical glass-PVT module achieves a performance quite similar to the best ones.
Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment (2006)

T cell helper type 2 (Th2) differentiation is driven by a source of IL-4 receptor (IL-4R) that mobilizes IL-4R signaling pathways and the transcription factor GATA-3. Naïve CD4 cells can secrete IL-4 independently of IL-4R signals, but how this secretion is regulated is not understood. Here we demonstrate that costimulation through the tumor necrosis factor receptor family molecule OX40, in synergy with CD28, is essential for high levels of nuclear factor of activated T cells c1 to accumulate in the nucleus of a recently activated naïve T cell. This action is not dependent on either IL-4R or IL-2R signals and results in OX40 controlling initial naïve T cell IL-4 transcription. OX40 signals subsequently enhance nuclear GATA-3 accumulation through an IL-4R-dependent action, leading to Th2 differentiation. These data show that, in the absence of an exogenous source of IL-4, OX40 provides a critical synergistic and temporal signal with other noncytokine receptors to modulate nuclear factor of activated T cells c1 and to promote optimal Th2 generation.
Secure Electronic Post Office (2002)

This paper describes the Secure Electronic Post Office (SEPO), a new electronic mail (e-mail) system that provides authentication, authorization, secure communications, pipeline, multiple receiver, anti-reply attack, assurance of message reception and routing control. SEPO is easy to implement, cross-platform, to build a regional or global e-mail system. For the internationalization purpose, the e-mail address SEPO adopts is a unicode character. The typical SEPO e-mail is composed of a postmark, stamp, envelope and letter. The letter is a simple file format to combine contexts, e-mail header, attachment files, etc. Unlike MIME, it does not increase the data size up to 33% and it is easy to process and requires less error handling. The envelope is designed to pack the letter and add some attributes about the sender, receiver and encryption of the letter. Furthermore, each e-mail address of SEPO can own several public key pairs to authenticate the e-mail and encrypt the symmetric session key used for encrypting the letter before transfer. The symmetric session key is stored in the envelope after it has been encrypted by the receiver public key.
Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors (2016)

Efficiency of differentiation of iPSC to IPC can be increased by concurrent expression of PDX1 and NKX6.1 during progenitor cells maturation. Protocols established in our study allow for iPSC generation and derivation of IPC in chemically defined conditions free from animal-derived components, which is of the utmost importance in the light of their prospective applications in the field of regenerative medicine.