gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Inhibition of the Mammalian β‐Lactamase Renal Dipeptidase (Dehydropeptidase‐I) by (Z)‐2‐(Acylamino)‐3‐Substituted‐propenoic Acids. (1987)

ChemInformVolume 18, Issue 47 Natural Products ChemInform Abstract: Inhibition of the Mammalian β-Lactamase Renal Dipeptidase (Dehydropeptidase-I) by (Z)-2-(Acylamino)-3-Substituted-propenoic Acids. D. W. GRAHAM, D. W. GRAHAM Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorW. T. ASHTON, W. T. ASHTON Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorL. BARASH, L. BARASH Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorJ. E. BROWN, J. E. BROWN Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorR. D. BROWN, R. D. BROWN Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorL. F. CANNING, L. F. CANNING Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorA. CHEN, A. CHEN Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorJ. P. SPRINGER, J. P. SPRINGER Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorE. F. ROGERS, E. F. ROGERS Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this author D. W. GRAHAM, D. W. GRAHAM Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorW. T. ASHTON, W. T. ASHTON Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorL. BARASH, L. BARASH Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorJ. E. BROWN, J. E. BROWN Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorR. D. BROWN, R. D. BROWN Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorL. F. CANNING, L. F. CANNING Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorA. CHEN, A. CHEN Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorJ. P. SPRINGER, J. P. SPRINGER Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this authorE. F. ROGERS, E. F. ROGERS Merck Sharp&Dohme Res. Lab., Rahway, NJ 07065, USASearch for more papers by this author First published: November 24, 1987 https://doi.org/10.1002/chin.198747321Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume18, Issue47November 24, 1987 RelatedInformation
Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration (2020)

Malignant gliomas are the most common and aggressive form of primary brain tumors, with a median survival of 15-20 months for patients receiving maximal interventions. Advances in nanomedicine have provided tumor-specific delivery of chemotherapeutics to potentially overcome their off-target toxicities. Recent advances in dendrimer-based nanomedicines have established that hydroxyl-terminated poly(amidoamine) dendrimers can intrinsically target neuroinflammation and brain tumors from systemic administration without the need for targeting moieties. The size of nanocarriers is a critical parameter that determines their tumor-targeting efficiency, intratumor distribution, and clearance mechanism. In this study, we explore the dendrimer size effects on brain tumor targeting capability in two clinically relevant orthotopic brain tumor models, the 9L rat and GL261 mouse models, which capture differing aspects of gliomas. We show that increasing dendrimers from Generation 4 to Generation 6 significantly enhances their tumor accumulation (~10-fold greater at 24 hr), tumor specificity (~2-3 fold higher), and tumor retention. The superior tumor targeting effect of G6 dendrimers is associated with its reduced renal clearance rate, resulting in longer circulation time compared to G4 dendrimers. Additionally, the increase in dendrimer generation does not compromise its homogeneous tumor distribution and intrinsic targeting of tumor-associated macrophages. These results validate the potential for these dendrimers as an effective, clinically translatable platform for effectively targeting tumor-associated macrophages in malignant gliomas.
IP fast rerouting for single-link/node failure recovery (2007)

Failure recovery in IP networks is critical to high quality service provisioning. The main challenge is how to achieve fast recovery without introducing high complexity and resource usage. Today’s networks mainly use route recalculation and lower layer protection. However, route recalculation could take as long as seconds to complete; while lower layer protection usually requires considerable bandwidth redundancy. We present two fast rerouting algorithms to achieve recovery from single-link and single-node failures, respectively. The idea is to calculated backup paths in advance. When a failure is detected, the affected packets are immediately forwarded through backup paths to shorten the service disruption. This paper answers the following questions: 1. How to find backup paths? 2. How to coordinate routers during the rerouting without explicit signaling? 3. How to realize distributed implementation? The schemes react to failures very fast because there are no calculations on the fly. They are also cost efficient because no bandwidth reservation is required. Our schemes guarantee 100% failure recovery without any assumption on the primary paths. Simulations show that our schemes yield comparable performance to shortest path route recalculation. This work illuminates the possibility of using pure IP layer solutions to build highly survivable yet cost-efficient networks.
Rational Structure‐Based Design of Bright GFP‐Based Complexes with Tunable Dimerization (2015)

Abstract Fluorescent proteins are transformative tools; thus, any brightness increase is a welcome improvement. We invented the “vGFP strategy” based on structural analysis of GFP bound to a single‐domain antibody, predicting tunable dimerization, enhanced brightness (ca. 50 %), and improved pH resistance. We verified all of these predictions using biochemistry, crystallography, and single‐molecule studies. We applied the vsfGFP proteins in three diverse scenarios: single‐step immunofluorescence in vitro (3× brighter due to dimerization); expression in bacteria and human cells in vivo (1.5× brighter); and protein fusions showing better pH resistance in human cells in vivo. The vGFP strategy thus allows upgrading of existing applications, is applicable to other fluorescent proteins, and suggests a method for tuning dimerization of arbitrary proteins and optimizing protein properties in general.
An <i>in situ</i> platform for the investigation of Raman shift in micro-scale silicon structures as a function of mechanical stress and temperature increase (2014)

Raman spectroscopy provides an accurate approach to measure temperature and stress in semiconductors at micro-scale and nano-scale. In the present work an in situ experimentation-based approach to separate a measured room to high temperature Raman shift signal into mechanical and thermal components when a uniaxial compressive load is applied in situ is presented. In situ uniaxial compressive loads were applied on examined silicon cantilever specimens from room temperature to 150 °C. The Raman shift measurements were performed as a function of strain at constant temperature and as a function of temperature at constant strain levels. The results show that the Raman shift measured at a given temperature under a given level of applied stress can be expressed as a summation of stress-induced Raman shift signal and temperature-induced Raman shift signal measured separately. For silicon, the stress-induced Raman shift is caused by inelastic interaction between the incident laser and the vibration of crystal lattice, while the temperature-induced Raman shift is caused by the anharmonic terms in the vibrational potential energy. Analyses indicate that such separation of Raman shift signal can be used to measure localized change in thermal conductivity and mechanical stress of semiconductor structures under applied stress.
ChemInform Abstract: DESIGN OF MORE POTENT ANTAGONISTS OF THE ANTIDIURETIC RESPONSES TO ARGININE‐VASOPRESSIN (1982)

Abstract Dargestellt und als antidiuretische Antagonisten untersucht werden die Analoga (I).
Compact and Wideband MMIC Phase Shifters Using Tunable Active Inductor-Loaded All-Pass Networks (2017)

To address the challenging needs of small size, wide bandwidth, and low-frequency applicability, a novel phase shifter implementation is introduced that utilizes tunable active differential inductors within all-pass networks. The inductor tuning is used to achieve phase shifts up to 180°. A switchable active balanced-to-unbalanced transition (balun) circuit is included in front of the all-pass network to complement its phase shift capability by another 180°. In addition, the all-pass network is followed by a variable-gain amplifier to correct for gain variations among the phase shifting states and act as an output buffer. Although active inductors have previously been used in the design of various components, to the best of our knowledge this is the first time that they have been used in an all-pass phase shifter. The approach is demonstrated with an on-chip design and implementation exhibiting wideband performance for S- and L-band applications by utilizing the 0.5-μm TriQuint pHEMT GaAs monolithic microwave integrated circuits (MMIC) process. Specifically, the presented phase shifter 1×3.95 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> die area and operates within the 1.5-3-GHz band (i.e., 2:1 bandwidth) with 10-dB gain, less than 1.5-dB root-mean-square (rms) gain error and less than 9° rms phase error. Comparison with the state-of-the-art MMIC phase shifters operating in Sand L-bands demonstrates that the presented phase shifter exhibits a remarkable bandwidth performance from a very compact footprint with low-power consumption. Consequently, it presents an alternative for the implementation of wideband phase shifters where all-passive implementations will consume expensive die real estate.
Radio frequency pumped mid-infrared waveguide lasers (1984)

RF discharge waveguide laser technology has been extended from the 10.6 μm CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> laser to include 2.7 μm HF, 3.8 μm DF, and several rare gas mid-infrared lasers. The maximum achieved electrical efficiencies of 5.3 and 4.0 percent were demonstrated in pulsed HF and DF systems, respectively. These, as well as several low efficiency rare gas lasers were demonstrated in a 20 cm gain length device. The output power and spectral distribution were determined as a function of the gas composition, pressure, velocity, and the RF power, pulse length, and repetition rate.
Reactive Ground-State Pathways Are Not Ubiquitous in Red/Green Cyanobacteriochromes (2013)

Recent characterization of the red/green cyanobacteriochrome (CBCR) NpR6012g4 revealed a high quantum yield for its forward photoreaction [J. Am. Chem. Soc. 2012, 134, 130-133] that was ascribed to the activity of hidden, productive ground-state intermediates. The dynamics of the pathways involving these ground-state intermediates was resolved with femtosecond dispersed pump-dump-probe spectroscopy, the first such study reported for any CBCR. To address the ubiquity of such second-chance initiation dynamics (SCID) in CBCRs, we examined the closely related red/green CBCR NpF2164g6 from Nostoc punctiforme. Both NpF2164g6 and NpR6012g4 use phycocyanobilin as the chromophore precursor and exhibit similar excited-state dynamics. However, NpF2164g6 exhibits a lower quantum yield of 32% for the generation of the isomerized Lumi-R primary photoproduct, compared to 40% for NpR6012g4. This difference arises from significantly different ground-state dynamics between the two proteins, with the SCID mechanism deactivated in NpF2164g6. We present an integrated inhomogeneous target model that self-consistently fits the pump-probe and pump-dump-probe signals for both forward and reverse photoreactions in both proteins. This work demonstrates that reactive ground-state intermediates are not ubiquitous phenomena in CBCRs.
Brush DC motors with concentrated windings and soft magnetic composites armatures (2002)

The armatures of conventional brush DC motors are using windings with interlocked coils elements. With this kind of distributed winding, the axial length of the end-windings is usually very important and their copper volume is large. In this paper, the authors present new structures of brush DC motor armature using a concentrated winding with a plurality of simple coils wound around the same tooth. The copper volume is about 60% lower than in the classical winding armature and the current commutation remains efficient. This kind of structure is well adapted to the use of soft magnetic composite materials for the realization of the magnetic circuit and can be used over a wide power range. The design method and a synthesis of these machines with concentrated winding armatures are presented. A prototype of concentrated winding brush DC motor is compared to a conventional motor used in a typical automotive application. The performance of the new structure in terms of torque to copper volume ratio is much higher than in the case of the classical structure.
Ex Vivo Rapamycin Generates Th1/Tc1 or Th2/Tc2 Effector T Cells With Enhanced In Vivo Function and Differential Sensitivity to Post-transplant Rapamycin Therapy (2006)

Rapamycin prevention of murine graft-versus-host disease (GVHD) is associated with a shift toward Th2- and Tc2-type cytokines. Recently, we found that use of rapamycin during ex vivo donor Th2 cell generation enhances the ability of adoptively transferred Th2 cells to prevent murine GVHD. In this study, using a method, without antigen-presenting cells, of T-cell expansion based on CD3,CD28 costimulation, we evaluated whether (1) rapamycin preferentially promotes the generation of Th2/Tc2 cells relative to Th1/Tc1 cells, (2) rapamycin-generated T-cell subsets induce cytokine skewing after allogeneic bone marrow transplantation (BMT), and (3) such in vivo cytokine skewing is sensitive to post-BMT rapamycin therapy. Contrary to our hypothesis, rapamycin did not preferentially promote Th2/Tc2 cell polarity, because rapamycin-generated Th1/Tc1 cells secreted type I cytokines (interleukin [IL]-2 and interferon-gamma) did not secrete type II cytokines (IL-4, IL-5, IL-10, or IL-13) and mediated fasL-based cytolysis. Rapamycin influenced T-cell differentiation, because each of the Th1, Th2, Tc1, and Tc2 subsets generated in rapamycin had increased expression of the central-memory T-cell marker, L-selectin (CD62L). Rapamycin-generated Th1/Tc1 and Th2/Tc2 cells were not anergic but instead had increased expansion after costimulation in vitro, increased expansion in vivo after BMT, and maintained full capacity to skew toward type I or II cytokines after BMT, respectively; further, rapamycin-generated Th1/Tc1 cells mediated increased lethal GVHD relative to control Th1/Tc1 cells. Rapamycin therapy after BMT in recipients of rapamycin-generated Th1/Tc1 cells greatly reduced Th1/Tc1 cell number, greatly reduced type I cytokines, and reduced lethal GVHD; in marked contrast, rapamycin therapy in recipients of rapamycin-generated Th2/Tc2 cells nominally influenced the number of Th2/Tc2 cells in vivo and did not abrogate post-BMT type II cytokine skewing. In conclusion, ex vivo and in vivo usage of rapamycin may be used to modulate the post-BMT balance of Th1/Tc1 and Th2/Tc2 cell subsets.
The microwave Doherty amplifier (2002)

A microwave Doherty amplifier has been designed using PHEMT devices in a novel configuration at L-band. Power-added efficiency of 61% is achieved at -1 dB gain compression in CW and is maintained at 61% at 5.5 dB back-off from the above point. The theory, design and measurement for this new amplifier are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A PLL clock generator with 5 to 110 MHz of lock range for microprocessors (1992)

A microprocessor clock generator based on an analog phase-locked loop (PLL) is described for deskewing the internal logic control lock to an external system lock. This PLL is fully generated onto a 1.2-million-transistor microprocessor in 0.8- mu m CMOS technology without the need for external components. It operates with a lock range from 5 to 110 MHz. The clock skew is less than 0.1 ns, with a peak-to-peak jitter of less than 0.3 ns for a 50-MHz system clock frequency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Differentially Fed Dual-Polarized Filtering Patch Antenna With Good Stopband Suppression (2020)

A differentially-fed dual-polarized filtering patch antenna with no extra filtering circuits involved is proposed. The filtering response is realized by symmetrically loading four short strips and a long cross-type strip, and a square ring slot to insert radiation zeros on the dual-polarized antenna element. The short and long strips can generate two transmission zeros at lower and upper band edges, respectively, leading to a sharp skirt selectivity. In addition, the long cross-type strip and the square ring slot can respectively introduce an extra resonance close to the original one, broadening the impedance bandwidth. Also, the equivalent circuit is presented to show that the two zeros can be brought by the two equivalent series resonant circuits extracted from the short/long strips resulting in the bandpass response. We may note that the proposed filtering structure owns the merits of simple, compact and complete symmetry, thus it can be well integrated with the dual- polarized antenna. Consequently, a compact and high-gain dual- polarized filtering antenna with good stopband suppression, low cross-polarization level and symmetrical radiation patterns is obtained. It can achieve an impedance bandwidth about 15% and a maximum gain of 8.4 dBi. The simulated cross-polarization level is below -40 dB, and the measured one is lower than -22 dB. Moreover, the upper stopband can be up to 2.6 f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> is the center frequency of the antenna), where the stopband radiations from all the directions can be suppressed and the measured suppression ratio can reach 90%.
A novel, glycan-dependent epitope in the V2 domain of human immunodeficiency virus type 1 gp120 is recognized by a highly potent, neutralizing chimpanzee monoclonal antibody (1994)

An anti-gp120 monoclonal antibody (MAb), C108G (gamma 1, kappa), was isolated from a chimpanzee that had been infected with strain IIIB of human immunodeficiency virus type 1 (HIV-1IIIB) and subsequently immunized with the recombinant glycoprotein rgp160MN. This MAb is specific for the IIIB strain of HIV-1 and related clones and exhibits very potent neutralization of these viruses; e.g., 100% neutralization of approximately 8 x 10(3) infectious units of HXB2 was achieved with 125 ng of C108G per ml. Commensurate with this potent neutralizing activity, the apparent affinity of C108G for rgp160LAI was very high, i.e., approximately 3 x 10(10) liters/mol. The C108G epitope was not destroyed by reduction of gp120 disulfide bonds but was profoundly disrupted by removal of N-linked sugars from gp120. Despite the importance of a glycan(s) in forming the C108G epitope, specific binding of C108G to synthetic peptides overlapping in amino acids 162 to 169 of the V2 region was detected, albeit with an affinity approximately 2,000-fold lower than that of C108G's binding to glycosylated envelope protein. This epitope mapping correlated with results of competition assays using MAbs of known epitope specificities. To our knowledge, this is the first description of an anti-V2 MAb raised in response to HIV-1 infection. Its potent neutralizing activity and epitope specificity indicate that the V2 domain of gp120 may be an effective target of the protective immune response and, therefore, potentially an important component of HIV vaccines.
Action Recognition from One Example (2010)

We present a novel action recognition method based on space-time locally adaptive regression kernels and the matrix cosine similarity measure. The proposed method uses a single example of an action as a query to find similar matches. It does not require prior knowledge about actions, foreground/background segmentation, or any motion estimation or tracking. Our method is based on the computation of novel space-time descriptors from the query video which measure the likeness of a voxel to its surroundings. Salient features are extracted from said descriptors and compared against analogous features from the target video. This comparison is done using a matrix generalization of the cosine similarity measure. The algorithm yields a scalar resemblance volume, with each voxel indicating the likelihood of similarity between the query video and all cubes in the target video. Using nonparametric significance tests by controlling the false discovery rate, we detect the presence and location of actions similar to the query video. High performance is demonstrated on challenging sets of action data containing fast motions, varied contexts, and complicated background. Further experiments on the Weizmann and KTH data sets demonstrate state-of-the-art performance in action categorization.
A robust video synchronization method based on hierarchical shot detection (2014)

We propose an video synchronization method using hierarchical video shot detection process to match two videos when one of them is modified at unknown locations. The shots include both abrupt and gradual transitions (dissolves and fade-groups). The philosophy of this method is to use a light weight method to pre-process the video to remove those frames which strictly does not comprise a normal scene and may contribute to fade-in, fade-out or dissolve areas. These frames are further processed by a complex and robust shot detection method to find the exact shot boundaries. We used object (contour) matching as a pre-processing step and SURF features on top of it for robust shot detection even in fade-in, fade-out or dissolve areas of the scene. Once all the shots are correctly found then the shot-boundaries are matched to identify the point of videos synchronization.
Thermotropic Poly(Ester-Amides) Based on Naphthalene Monomers (1988)

Abstract The structure and properties of a range of thermotropic poly(ester-amides) derived from 2,6-naphthalene derivatives is described. Many of these polymers may be melt-processed into fibers, monofils, and molded structures having very attractive physical and mechanical properties. A variety of monomers has been used and structure/composition/property relationships are described along with details of synthesis and processing conditions. Both fibers and molded articles may be heat-treated to enhance their tensile properties. Molded articles and extruded rods have exceptional tensile moduli in the unfilled state.