gebhart/patrepeval huggingface dataset:
Bradykinin Receptor Antagonists Containing N-Substituted Amino Acids:  <i>In Vitro</i> and <i>in Vivo</i> B<sub>2</sub> and B<sub>1</sub> Receptor Antagonist Activity (1996)

We report a systematic probing of the structural requirements of the bradykinin (BK) type 2 (B(2)) receptor for antagonist activity by incorporating N-alkyl-amino acid residues at positions 7 and 8 of a potent antagonist sequence. Compound 1 (D-Arg(0)-Arg(1)-Pro(2)-Hyp(3)-Gly(4)-Thi(5)-Ser(6)-D-Tic(7)-N-Chg (8)-Arg(9), CP-0597)(1,2) is a potent (pA(2) = 9.3, rat uterus; pK(i) = 9.62, binding, human receptor clone) B(2) receptor antagonist devoid of in vitro B(1) antagonist activity (rabbit aorta). Compound 1 exhibits high potency (ED(50) = 29.2 pmol/kg/min, iv, rabbit) and duration of action when tested in models for in vivo B(2) antagonist activity. Although devoid of activity in a classic B(1) isolated tissue assay, B(1) antagonist activity for 1 was demonstrated in vivo, in a LPS-treated, inducible BK(1) receptor rabbit blood pressure model (ED(50) = 1.7 nmol/kg/min). D-Arg(0) of 1 can be formally replaced by an achiral arginine surrogate, without significant loss in antagonist potency on rat uterus (compound 11, B(2) pA(2) = 9.1). Antagonist 13 (Hyp(2), Nchg(8)), pK(i) = 10.2, and agonist 4 (N-methylcyclohexyl-Gly(8)), pK(i) = 10.1, also exhibited substantial binding to guinea pig ileum membrane receptors as well as a human B(2) receptor clone. Very minor structural changes in the N-alkyl amino acid residues in positions 7 and 8 can modify the activity of this class of compounds from being extremely potent antagonists to tight binding partial or full agonists. These studies have resulted in a series of compounds containing inexpensive amino acid residues but which produce broad spectrum BK receptor blocking potency and exceptional in vivo duration of action.
DLGNet: A Transformer-based Model for Dialogue Response Generation (2019)

Neural dialogue models, despite their successes, still suffer from lack of relevance, diversity, and in many cases coherence in their generated responses. These issues can attributed to reasons including (1) short-range model architectures that capture limited temporal dependencies, (2) limitations of the maximum likelihood training objective, (3) the concave entropy profile of dialogue datasets resulting in short and generic responses, and (4) the out-of-vocabulary problem leading to generation of a large number of tokens. On the other hand, transformer-based models such as GPT-2 have demonstrated an excellent ability to capture long-range structures in language modeling tasks. In this paper, we present DLGNet, a transformer-based model for dialogue modeling. We specifically examine the use of DLGNet for multi-turn dialogue response generation. In our experiments, we evaluate DLGNet on the open-domain Movie Triples dataset and the closed-domain Ubuntu Dialogue dataset. DLGNet models, although trained with only the maximum likelihood objective, achieve significant improvements over state-of-the-art multi-turn dialogue models. They also produce best performance to date on the two datasets based on several metrics, including BLEU, ROUGE, and distinct n-gram. Our analysis shows that the performance improvement is mostly due to the combination of (1) the long-range transformer architecture with (2) the injection of random informative paddings. Other contributing factors include the joint modeling of dialogue context and response, and the 100% tokenization coverage from the byte pair encoding (BPE).
Application of optical similarity in OPC model calibration (2017)

The ability to calibrate optical proximity correction (OPC) models accurately and efficiently is desired to minimize the lithography process development time. To compare layout features used for lithography process model calibration, the concept of optical similarity is introduced that is derived from the optical intensity used in OPC models. The optical similarity analysis is based on comparing contributions to the overall intensity from the different optical kernels. Optical similarity is applied in comparing individual features as well as in the analysis of pattern coverage between sets of features used in calibration of models for OPC. A method for selecting features for calibration from a larger set of features is described. A systematic approach to apply relative weights to different calibration features in order to improve model fit on complex verification data is also presented. This systematic approach to feature comparisons and pattern coverage derived from optical properties is demonstrated on numerous examples from production lithography. The methods presented here can improve the feature selection process for model calibration to ensure pattern coverage relative to full chip layout and hence improve the overall OPC model quality.
Reversible and Irreversible Chemisorption in Nonporous‐Crystalline Hybrids (2013)

Abstract The tools of synthetic chemistry allow us to fine‐tune the reactivity of molecules at a level of precision not yet accessible with inorganic solids. We have investigated hybrids that couple molecules to the superior thermal and mechanical properties of solids. Herein we present, to the best of our knowledge, the first demonstration of reactivity between hybrid perovskites and substrates. Reaction with iodine vapor results in a remarkable expansion of these materials (up to 36 % in volume) where new covalent CI bonds are formed with retention of crystallinity. These hybrids also show unusual examples of reversible chemisorption. Here, solid‐state interactions extend the lifetime of molecules that cannot be isolated in solution. We have tuned the half‐lives of the iodinated structures from 3 h to 3 days. These nonporous hybrids drive substrate capture and controlled release through chemical reactivity. We illustrate the strengths of the hybrid by considering radioactive iodine capture.
Hyaluronan- and Heparin-Reduced Silver Nanoparticles with Antimicrobial Properties (2009)

These results suggest that DAPHP and HA silver nanoparticles have potential in antimicrobial therapeutic applications.
Image Compression via Colorization Using Semi-Regular Color Samples (2013)

We improves colorization-based image compression by sparsely sampling color points on a semi-regular grid and compressing them using JPEG. We generate variations of sampling locations based on extreme gray-scale values to to further improve PSNR.
Frequency metrology via quantum interference in two-photon excitation (2002)

Quantum interference in atomic two-photon excitation is exploited for optical demodulation, with phase-sensitive detection at /spl plusmn/12 THz having been achieved. By utilizing the atoms as ultrafast nonlinear mixing elements, a new technique for the comparison of essentially arbitrary frequencies over the range 200-2000 nm is presented.
A Neutralizing Prolactin Receptor Antibody Whose In Vivo Application Mimics the Phenotype of Female Prolactin Receptor-Deficient Mice (2015)

The prolactin receptor (PRLR) has been implicated in a variety of physiological processes (lactation, reproduction) and diseases (breast cancer, autoimmune diseases). Prolactin synthesis in the pituitary and extrapituitary sites is regulated by different promoters. Dopamine receptor agonists such as bromocriptine can only interfere with pituitary prolactin synthesis and thus do not induce a complete blockade of PRLR signaling. Here we describe the identification of a human monoclonal antibody 005-C04 that blocks PRLR-mediated signaling at nanomolar concentrations in vitro. In contrast to a negative control antibody, the neutralizing PRLR antibody 005-C04 inhibits signal transducer and activator of transcription 5 phosphorylation in T47D cells and proliferation of BaF3 cells stably expressing murine or human PRLRs in a dose-dependent manner. In vivo application of this new function-blocking PRLR antibody reflects the phenotype of PRLR-deficient mice. After antibody administration female mice become infertile in a reversible manner. In lactating dams, the antibody induces mammary gland involution and negatively interferes with lactation capacity as evidenced by reduced milk protein expression in mammary glands and impaired litter weight gain. Antibody-mediated blockade of the PRLR in vivo stimulates hair regrowth in female mice. Compared with peptide-derived PRLR antagonists, the PRLR antibody 005-C04 exhibits several advantages such as higher potency, noncompetitive inhibition of PRLR signaling, and a longer half-life, which allows its use as a tool compound also in long-term in vivo studies. Therefore, we suggest that this antibody will help to further our understanding of the role of auto- and paracrine PRLR signaling in health and disease.
Control of viral replication and disease onset in cynomolgus monkeys by HIV-1 TAT vaccine. (2000)

The Tat protein of HIV is produced early after infection and it is essential for viral replication and transmission. Tat is released by infected lymphocytes and is detected in the serum of HIV-infected patients. Extracellular Tat enters cells, where promotes HIV replication. Several studies suggest that humoral and cellular anti-Tat immunity have a protective role and may control disease progression. Of importance, Tat is conserved in its immunogenic regions among all viral subtypes except O subtype. Thus, the immunization with Tat cannot block virus entry but might block HIV replication and progression to disease. To test this hypothesis, monkeys (Macaca fascicularis) were immunized with a biologically active Tat protein. Tat was non toxic and induced specific humoral and cellular immune responses. High titers of anti-Tat antibodies capable of neutralizing Tat activity and the in vitro infection with the SHIV89.6P, Tat-specific proliferation, CTLs, TNFalpha production and skin tests were detected in the vaccinated monkeys. Most importantly, upon challenge with the highly pathogenic SHIV89.6P (10 MID50, i.v.), 5/7 of the vaccinated monkeys showed no signs of infection nor CD4+-T cell decline over a 19 months of follow-up, whereas 3/3 controls were highly infected. Thus, a Tat-vaccine is capable of controlling the acute phase of infection in nonhuman primates. These data open new avenues for the development of an AIDS vaccine.
How to reuse a "write - once " memory (Preliminary Version) (1982)

Storage media such as digital optical disks, PROMS, or paper tape consist of a number of “write-once” bit positions (wits); each wit initially contains a “0” that may later be irreversibly overwritten with a “I”. We demonstrate that such “write-once memories” (woms) can be “rewritten” to a surprising degree. For example, only 3 wits suffice to represent any 2-bit value in a way that can later be updated to represent any other 2-bit value. For large k, 1.29... k wits suffice to represent a k-bit value in a way that can be similarly updated. Most surprising, allowing t writes of a k-bit value requires only t + o(t) wits, for any fixed k. For fixed t, approximately k.t/log(t) wits are required as k → @@@@. An n-wit WOM is shown to have a “capacity” (i.e. k.t when writing a k-bit value t times) of up to n.log(n) bits.
Model reduction of time-varying linear systems using approximate multipoint Krylov-subspace projectors (1998)

h this paper a method is presented for model reduction of systemsdescribedby time-var-ying differential-algebraicequations. ~i method aUowsautomated extraction of reduced modek for nordinearM blocks,such as mixers and ~ters, that havea near-Enear signalpath but may containstronglynordinear time-varyingcomponents. me modek have the accuracy of a transistor-levelnordinearsimulationbut are very compact and so can be used in system-levelsimulationand design. me modelreductionprocedureis basedona multipointrational approximationalgorithm formed by orthogonalprojection of the originaltime-varyingHnearsystemintoan approximate@lov subspace. me modek obtainedfrom the approximate fiylovsubspaceprojector an be obtainedmuch more easilythan the exact projectors but shownegligibledifferencein accuracy.
Recording of volume hologram using a beam pattern from tapered optical fiber (1997)

A photorefractive volume hologram was recorded and probed using light diffracted from a tapered optical fiber as a reference beam. A single-mode fiber (SMF) was chemically etched and tapered to give a complicated beam pattern, and it is shown that the tapered optical fiber can be utilized to increase the storage density of the volume hologram. Spatial selectivity of the volume hologram with this method was increased by two times compared to the normal SMF referencing, which is due to the fact that the complicated beam pattern has little correlation with its shifted version.
Genetics of Borrelia burgdorferi. (1991)

Structural analysis by electronmicroscopy and pulsed field agarose gel electrophoresis of the genome of Borrelia burgdorferi has revealed a 1000 kilobase (kb) chromosome and a unique type of extra chromosomal linear DNA, as well as supercoiled circular DNA. The plasmid DNA ranged in size from 1.5 to 50 kb. Gene mapping of the ospA and ospB genes have placed them on the 49 kb linear plasmid molecule. The osp operon of B. burgdorferi has been extensively characterized at the molecular level.
Evaluation of dual-axis fatigue testing of large wind turbine blades (2011)

Full-scale fatigue testing is part of the certification process for large wind turbine blades. That testing is usually performed about the flapwise and edgewise axes independently but a new method for resonant fatigue testing has been developed in which the flapwise and edgewise directions are tested simultaneously, thus also allowing the interactions between the two mutually perpendicular loads to be investigated. The method has been evaluated by comparing the Palmgren–Miner damage sum around the cross-section at selected points along the blade length that results from a simulated service life, as specified in the design standards, and testing. Bending moments at each point were generated using wind turbine simulation software and the test loads were designed to cause the same amount of damage as the true service life. The mode shape of the blade was tuned by optimising the position of the excitation equipment, so that the bending moment distribution was as close as possible to the target loads. The loads were converted to strain–time histories using strength of materials approach, and fatigue analysis was performed. The results show that if the bending moment distribution is correct along the length of the blade, then dual-axis resonant testing tests the blade much more thoroughly than sequential tests in the flapwise and edgewise directions. This approach is shown to be more representative of the loading seen in service and can thus contribute to a potential reduction in the weight of wind turbine blades and the duration of fatigue tests leading to reduced cost.
Vertically Aligned Niobium Nanowire Arrays for Fast‐Charging Micro‐Supercapacitors (2017)

Planar micro-supercapacitors are attractive for system on chip technologies and surface mount devices due to their large areal capacitance and energy/power density compared to the traditional oxide-based capacitors. In the present work, a novel material, niobium nanowires, in form of vertically aligned electrodes for application in high performance planar micro-supercapacitors is introduced. Specific capacitance of up to 1 kF m<sup>-2</sup> (100 mF cm<sup>-2</sup> ) with peak energy and power density of 2 kJ m<sup>-2</sup> (6.2 MJ m<sup>-3</sup> or 1.7 mWh cm<sup>-3</sup> ) and 150 kW m<sup>-2</sup> (480 MW m<sup>-3</sup> or 480 W cm<sup>-3</sup> ), respectively, is achieved. This remarkable power density, originating from the extremely low equivalent series resistance value of 0.27 Ω (2.49 µΩ m<sup>2</sup> or 24.9 mΩ cm<sup>2</sup> ) and large specific capacitance, is among the highest for planar micro-supercapacitors electrodes made of nanomaterials.
Comparison of a new self developing photopolymer with AA/PVA based photopolymer utilizing the NPDD model (2011)

The development of suitable recording media for applications such as holographic optical elements and holographic data storage are of significant research and commercial interest. In this paper, a photopolymer material developed by Bayer MaterialScience is examined using various optical techniques and then characterised using the Non-local Photo-polymerization Driven Diffusion model. This material demonstrates the capabilities of a new class of photopolymer offering high index modulation, full colour recording, high light sensitivity and environmental stability. One key result of this study is the material's high spatial frequency resolution, indicating a very low non-local effect, thus qualifying it as a very good storage medium.
Artificial Intelligence to Stratify Severity of Age-Related Macular Degeneration (AMD) and Predict Risk of Progression to Late AMD (2020)

Noninvasive, highly accurate, and fast AI methods to screen for referral level AMD and to predict late AMD progression offer significant potential improvements in our care of this prevalent blinding disease.
Array Antennas With Jointly Optimized Elements Positions and Dimensions Part II: Planar Circular Arrays (2013)

The paper describes a deterministic algorithm based on simple analytical equations for designing planar circular sparse array antennas where the positions and the dimensions of the radiating elements are jointly exploited and optimized. The proposed solution permits addressing one of the main limitations associated to sparse arrays, i.e., their poor aperture efficiency especially when patterns with low sidelobe levels are obtained using only the density of the elements avoiding any amplitude tapering. The accuracy of the method is guaranteed by the fact that the achieved directivity differs from the target value, associated to a continuous reference aperture distribution, by a quantity asymptotically equal to the factor π/4 (corresponding to about -1.05 dB) representing the filling factor of a circular planar array organized in concentric rings populated by circular apertures. As required for several applications, the method includes the possibility to add a constraint on the maximum scanning angle with respect to the boresight direction.
Transfusive image manipulation (2012)

We present a method for consistent automatic transfer of edits applied to one image to many other images of the same object or scene. By introducing novel, content-adaptive weight functions we enhance the non-rigid alignment framework of Lucas-Kanade to robustly handle changes of view point, illumination and non-rigid deformations of the subjects. Our weight functions are content-aware and possess high-order smoothness, enabling to define high-quality image warping with a low number of parameters using spatially-varying weighted combinations of affine deformations. Optimizing the warp parameters leads to subpixel-accurate alignment while maintaining computation efficiency. Our method allows users to perform precise, localized edits such as simultaneous painting on multiple images in real-time, relieving them from tedious and repetitive manual reapplication to each individual image.
Heisenbyte (2015)

Vulnerabilities that disclose executable memory pages enable a new class of powerful code reuse attacks that build the attack payload at runtime. In this work, we present Heisenbyte, a system to protect against memory disclosure attacks. Central to Heisenbyte is the concept of destructive code reads -- code is garbled right after it is read. Garbling the code after reading it takes away from the attacker her ability to leverage memory disclosure bugs in both static code and dynamically generated just-in-time code. By leveraging existing virtualization support, Heisenbyte's novel use of destructive code reads sidesteps the problem of incomplete binary disassembly in binaries, and extends protection to close-sourced COTS binaries, which are two major limitations of prior solutions against memory disclosure vulnerabilities. Our experiments demonstrate that Heisenbyte can tolerate some degree of imperfect static analysis in disassembled binaries, while effectively thwarting dynamic code reuse exploits in both static and JIT code, at a modest 1.8% average runtime overhead due to virtualization and 16.5% average overhead due to the destructive code reads.
Narrow band interference cancelation in OFDM: Astructured maximum likelihood approach (2012)

This paper presents a maximum likelihood (ML) approach to mitigate the effect of narrow band interference (NBI) in a zero padded orthogonal frequency division multiplexing (ZP-OFDM) system. The NBI is assumed to be time variant and asynchronous with the frequency grid of the ZP-OFDM system. The proposed structure based technique uses the fact that the NBI signal is sparse as compared to the ZP-OFDM signal in the frequency domain. The structure is also useful in reducing the computational complexity of the proposed method. The paper also presents a data aided approach for improved NBI estimation. The suitability of the proposed method is demonstrated through simulations.
A new device for performing reference point indentation without a reference probe (2012)

Here we describe a novel, hand-held reference point indentation (RPI), instrument that is designed for clinical measurements of bone material properties in living patients. This instrument differs from previous RPI instruments in that it requires neither a reference probe nor removal of the periosteum that covers the bone, thus significantly simplifying its use in patient testing. After describing the instrument, we discuss five guidelines for optimal and reproducible results. These are: (1) the angle between the normal to the surface and the axis of the instrument should be less than 10°, (2) the compression of the main spring to trigger the device must be performed slowly (>1 s), (3) the probe tip should be sharper than 10 μm; however, a normalized parameter with a calibration phantom can correct for dull tips up to a 100 μm radius, (4) the ambient room temperature should be between 4 °C and 37 °C, and (5) the effective mass of the bone or material under test must exceed 1 kg, or if under 1 kg, the specimen should be securely anchored in a fixation device with sufficient mass (which is not a requirement of previous RPI instruments). Our experience is that a person can be trained with these guidelines in about 5 min and thereafter obtain accurate and reproducible results. The portability, ease of use, and minimal training make this instrument suitable to measure bone material properties in a clinical setting.
Distributed Graph Layout for Sensor Networks (2005)

Sensor network applications frequently require that the sensors know their physical locations in some global coordinate system. This is usually achieved by equipping each sensor with a location measurement device, such as GPS. However, low-end systems or indoor systems, which cannot use GPS, must locate themselves based only on crude information available locally, such as inter-sensor distances. We show how a collection of sensors, capable only of measuring distances to close neighbors, can compute their locations in a purely distributed manner, i.e. where each sensor communicates only with its neighbors. This can be viewed as a distributed graph drawing algorithm. We experimentally show that our algorithm consistently produces good results under a variety of simulated real-world conditions, and is relatively robust to the presence of noise in the distance measurements.