gebhart/patrepeval huggingface dataset:
Loudness Ratio Production by Cochlear Implantees Using the Spectral Maxima Sound Processor (1996)

The loudness growth characteristics of five users of the Mini System 22 implant and the Spectral Maxima Sound Processor were measured and compared with those of five normally hearing subjects. The main objective was to evaluate the suitability of the function employed in the sound processor that converts acoustic input levels of electrical stimulation. The method of loudness ratio production was used. The average result of the normally hearing subjects for halving and doubling loudness was 10.8 dB. The results of three of the implantees were comparable with those of the normally hearing subjects (average 8.83 dB), while those of the remaining subjects were quantitatively and qualitatively different. Investigation showed that altering the amplitude conversion function in the sound processor would not make the results of these two implantees more like those of the other subjects. However, it is possible that their responses were affected by the limited input dynamic range of the sound processor.
Developing New Low-Temperature Admixtures for Concrete. A Field Evaluation. (1997)

Two new admixtures, capable of preventing water from freezing, as well as increasing the hydration rate of cement at below-freezing temperatures, were field tested at Sault Ste. Marie, Michigan. Concrete made with the admixtures was placed on a frozen subgrade during a cold winter day and was allowed to cure thermally, unprotected in the cold. Comparison to control concrete placed inside a heated shelter showed that the unprotected, admixtured concrete was equal to the control in strength and appearance. Work is continuing on the development of these admixtures for commercial use.
Field Method for the Determination of Hexavalent Chromium by Ultrasonication and Strong Anion-Exchange Solid-Phase Extraction (1999)

A simple, fast, sensitive, and economical field method was developed and evaluated for the determination of hexavalent chromium (CrVI) in environmental and workplace air samples. By means of ultrasonic extraction in combination with a strong anion-exchange solid-phase extraction (SAE-SPE) technique, the filtration, isolation, and determination of CrVI in the presence of trivalent chromium (CrIII) and potential interferents was achieved. The method entails (1) ultrasonication in basic ammonium buffer solution to extract CrVI from environmental matrixes; (2) SAE-SPE to separate CrVI from CrIII and interferences; (3) elution/acidification of the eluate; (4) complexation of chromium with 1,5-diphenylcarbazide; and (5) spectrophotometric determination of the colored chromium-diphenylcarbazone complex. Several critical parameters were optimized in order to effect the extraction of both soluble (K2CrO4) and insoluble (PbCrO4) forms of CrVI without inducing CrIII oxidation or CrVI reduction. The method allowed for the dissolution and purification of CrVI from environmental and workplace air sample matrixes for up to 24 samples simultaneously in less than 90 min (including ultrasonication). The results demonstrated that the method was simple, fast, quantitative, and sufficiently sensitive for the determination of occupational exposures of CrVI. The method is applicable for on-site monitoring of CrVI in environmental and industrial hygiene samples.
sideSPIM – selective plane illumination based on a conventional inverted microscope (2017)

Previously described selective plane illumination microscopy techniques typically offset ease of use and sample handling for maximum imaging performance or <i>vice versa</i>. Also, to reduce cost and complexity while maximizing flexibility, it is highly desirable to implement light sheet microscopy such that it can be added to a standard research microscope instead of setting up a dedicated system. We devised a new approach termed sideSPIM that provides uncompromised imaging performance and easy sample handling while, at the same time, offering new applications of plane illumination towards fluidics and high throughput 3D imaging of multiple specimen. Based on an inverted epifluorescence microscope, all of the previous functionality is maintained and modifications to the existing system are kept to a minimum. At the same time, our implementation is able to take full advantage of the speed of the employed sCMOS camera and piezo stage to record data at rates of up to 5 stacks/s. Additionally, sample handling is compatible with established methods and switching magnification to change the field of view from single cells to whole organisms does not require labor intensive adjustments of the system.
BUBR1 phosphorylation is regulated during mitotic checkpoint activation. (1999)

Eukaryotic cells have evolved a mechanism that delays the progression of mitosis until condensed chromosomes are properly positioned on the mitotic spindle. To understand the molecular basis of such monitoring mechanism in human cells, we have been studying genes that regulate the mitotic checkpoint. Our early studies have led to the cloning of a full-length cDNA encoding MAD3-like protein (also termed BUBR1/MAD3/SSK1). Dot blot analyses show that BUBR1 mRNA is expressed in tissues with a high mitotic index but not in differentiated tissues. Western blot analyses show that in asynchronous cells, BUBR1 protein primarily exhibits a molecular mass of 120 kDa, and its expression is detected in most cell lines examined. In addition, BUBR1 is present during various stages of the cell cycle. As cells enter later S and G2, BUBR1 levels are increased significantly. Nocodazole-arrested mitotic cells obtained by mechanical shake-off contain BUBR1 antigen with a slower mobility on denaturing SDS gels. Phosphatase treatment restores the slowly migrating band to the interphase state, indicating that the slow mobility of the BUBR1 antigen is attributable to phosphorylation. Furthermore, purified recombinant His6-BUBR1 is capable of autophosphorylation. Our studies indicate that BUBR1 phosphorylation status is regulated during spindle disruption. Considering its strong homology to BUB1 protein kinase, BUBR1 may also play an important role in mitotic checkpoint control by phosphorylation of a critical cellular component(s) of the mitotic checkpoint pathway.
Leveraging Genetic-Background Effects in Saccharomyces cerevisiae To Improve Lignocellulosic Hydrolysate Tolerance (2016)

Recent studies on natural variation within Saccharomyces cerevisiae have uncovered substantial phenotypic diversity. Here, we took advantage of this diversity, using it as a tool to infer the effects of combinatorial stress found in lignocellulosic hydrolysate. By comparing sensitive and tolerant strains, we implicated primary cellular targets of hydrolysate toxins and elucidated the physiological states of cells when exposed to this stress. We also explored the strain-specific effects of gene overexpression to further identify strain-specific responses to hydrolysate stresses and to identify genes that improve hydrolysate tolerance independent of strain background. This study underscores the importance of studying multiple strains to understand the effects of hydrolysate stress and provides a method to find genes that improve tolerance across strain backgrounds.
SoftArchViz: A Software Architecture Visualization Tool (2007)

This tool presents a technique for visualizing large software architectures using the Multi-Dimensional Scaling Algorithm. Our visualization tool, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SoftArchViz</i> , can be used to study different architectural views that represent different attributes of the software components. We visualize the architecture of the Network Appliance <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">™</sup> operating system known as Data ONTAP®7G (ON-TAP) using graphical "glyphs" representing individual software components that vary their <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">spatial position</i> , <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">color<i/>, and <i>texture properties</i> to encode the components' attribute values. We also represent the correspondence in the architecture at different stages of the development cycle and thereby identify all the components that changed and the extent of those changes, and thus evaluate the actual implementation of the architecture.</i>
Abstract 651: <i>Ex vivo</i> and <i>in vivo</i> characterization of IPH4102, a humanized anti-KIR3DL2 antibody for the treatment of cutaneous T-cell lymphomas (2014)

Abstract KIR3DL2 belongs to the killer immunoglobulin (Ig)-like receptors (KIRs) family and is composed of three extracellular Ig-like domains. KIR3DL2 is naturally expressed on some NK cells and minor subpopulations of CD8+ and CD4+ T cells. Physiologically, KIRD3L2 is an inhibitory receptor for human leukocyte antigen (HLA) class I molécules regulating NK cell activation. Interestingly, KIR3DL2 is also expressed on several subtypes of T lymphomas/leukemias, and in particular on Advanced cutaneous T cell lymphomas (CTCL), making it a unique therapeutic target in cancer. From a wide collection of anti-KIR3DL2 monoclonal antibodies (mAbs) with distinct properties related to several epitopes, we have selected IPH4102 as the lead therapeutic candidate. IPH4102 is a humanized IgG1 that selectively kills KIR3DL2-positive cells in vitro, mainly through antibody-dependent cell cytotoxicity (ADCC). IPH4102 also improves survival of mice engrafted with KIR3DL2-positive tumors. More importantly, IPH4102 exerts remarkable anti-tumor activity against primary KIR3DL2-positive tumor cells ex vivo: using blood taken from Sézary Syndrome patients as experimental model, we demonstrated the efficient killing of primary leukemic cells by autologous NK cells engaged by IPH4102. IPH4102 IND-enabling studies are ongoing. In parallel, other anti-KIR3DL2 mAbs were also developed as unique and sensitive tools for the detection by immunohistochemistry of KIR3DL2 on tumor biopsies. Owing to its efficacy profile and to the highly restricted expression pattern of its target KIR3DL2, IPH4102 stands as a very promising therapeutic option for the treatment of advanced cutaneous T cell lymphomas. Citation Format: Anne Marie-Cardine, Nicolas Viaud, Arnaud Dujardin, Rachel Joly, Laurent Gauthier, Cecile Bonnafous, Mathieu Blery, Carine Paturel, Armand Bensussan, Martine Bagot, Helene Sicard. Ex vivo and in vivo characterization of IPH4102, a humanized anti-KIR3DL2 antibody for the treatment of cutaneous T-cell lymphomas . [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 651. doi:10.1158/1538-7445.AM2014-651
Enhanced piezoelectricity and nature of electric-field induced structural phase transformation in textured lead-free piezoelectric Na0.5Bi0.5TiO3-BaTiO3 ceramics (2012)

This letter provides a comparative description of the properties of textured and randomly oriented poly-crystalline lead-free piezoelectric 0.93(Na0.5Bi0.5TiO3)-0.07BaTiO3 (NBT-BT) ceramics. A high longitudinal piezoelectric constant of (d33) ∼ 322 pC/N was obtained in (001)PC textured NBT-7BT ceramics, which is almost ∼2× times the d33 coefficient reported for randomly oriented ceramics of the same composition. In situ neutron diffraction experiments revealed that characteristically different structural responses are induced in textured and randomly oriented NBT-BT ceramics upon application of electric fields (E), which are likely related to the varying coherence lengths of polar nanoregions and internal stresses induced by domain switching.
Antitumor Agents, 90. Bruceantinoside C, a New Cytotoxic Quassinoid Glycoside from Brucea antidysenterica (1987)

Three cytotoxic, quassinoid glycosides, the new bruceantinoside C [1] and the known yadanziosides G [2] and N [3] were isolated from the stem of Brucea antidysenterica. The structures of 1-3 were determined from their spectral data.
The Three-Phase Ground-Fault Circuit-Interrupter System - a novel approach to prevent electrocution (2008)

There are many electrocutions that occur on three-phase 480 and 600 volt systems, particularly 277 or 347 volt lighting branch circuits. Ground-fault circuit-interrupters (GFCIs) have saved many lives on 120 volt and 120-240 volt single-phase systems since being introduced to the National Electrical Code <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> (NEC) in 1971. Application of GFCIs at voltages higher than 120 volts has not progressed because the higher voltages to ground result in higher capacitive charging current of branch and feeder circuits, which in turn leads to ldquonuisance trips.rdquo This paper first describes the mechanism of electrical shock, let-go threshold current, and heart ventricular fibrillation. It then describes the three-phase ground-fault circuit-interrupter system (GFCIS-3Ph) that overcomes nuisance tripping by a novel approach to sensing and tripping logic. The system is most applicable for lighting branch circuits due to the historical risk of these circuits, but the GFCIS-3Ph is also appropriate to be considered as an option for all three-phase branch or feeder circuits. Application of the GFCIS-3Ph technology has the potential to almost eliminate electrocution for persons who make direct contact between an energized phase conductor and ground on three-phase systems rated below 1000 volts, phase-to-phase.
An efficient frequency-domain algorithm for discrete orthogonal basis restoration (1998)

Discrete orthogonal basis restoration (DOBR) is a robust method for the inverse solution of linear systems of the type [A][o]=(i), where [A] may be either shift variant or invariant. Presented in this work is the derivation of a frequency-domain DOBR algorithm that significantly improves computational efficiency. Substantial reductions in the number of arithmetic operations are possible when system stationarity allows the use of precalculated DOBR characteristic vector sets, and sampling of the signal is rapid relative to the highest frequency of interest. More modest improvements in computational efficiency (10%-40%) are obtained when the entire DOBR algorithm must be executed. In addition to reducing the number of floating-point operations and storage requirements, the frequency-domain DOBR algorithm lessens the deleterious effects of perturbations in [A] on the inverse solution.
Recombinant Immunotoxin with T-cell Epitope Mutations That Greatly Reduce Immunogenicity for Treatment of Mesothelin-Expressing Tumors (2015)

SS1P is a recombinant immunotoxin (RIT) that targets mesothelin. It consists of an antimesothelin Fv fused to a portion of Pseudomonas exotoxin A. In clinical studies, it has produced dramatic responses in patients with advanced mesothelioma, when combined with immunosuppressive therapy so that several treatment cycles could be given. Otherwise its activity is limited by its immunogenicity. In this work, we describe the development and characterization of LMB-T20, a highly potent RIT targeted at mesothelin-expressing cancers with low immunogenicity due to removal of its eight T-cell epitopes. LMB-T20 was more active than SS1P when tested on four different mesothelin-expressing cell lines as well as on cells obtained from patients with mesothelioma. It also has potent antitumor activity in mice, and has reduced immunogenicity as measured by cytokine secretion assays. In conclusion, LMB-T20 is a favorable candidate for evaluation in clinical trials due to its reduced immunogenicity and excellent activity.
Fiber based frequency comb system and application tests (2006)

Er <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> -doped fiber-lasers efficiently generate frequency-combs for optical frequency metrology. 3.5 nJ energy, 35 fs duration and 100 MHz repetition-rate laser pulses are used to obtain an octave spanning frequency-comb in the visible.
A stepping on-time adjustment method for interleaving three-channel critical mode boost PFC converter (2013)

This paper proposes a stepping on-time adjustment (SOTA) control method with status judgment for multichannel interleaving critical mode (CRM) boost PFC converter. The interleaved control is a trend for high power applications. However, conventional interleaved methods are complicated to implement when more than two channels are required. The SOTA method with status judgment is proposed to simplify the complex control in multi-channel applications. This method not only increases the stability, but also improves the dynamic response. In this paper, the simulation and experimental results of a 600W three-channel interleaved CRM boost PFC converter are shown to verify the feasibility of the proposed SOTA method.
Real time monitoring and quality control of resistance spot welds using voltage, current, and force data (2004)

The real time monitoring and control of resistance spot welds is a problem of critical importance in automotive and many other manufacturing industries. However, till this date, there are no reliable, low-cost, non-destructive techniques for predicting the size and strength of the weld nuggets in real time. This paper investigates the usage of voltage, current, and force data for the above tasks. A promising technique for estimation of nugget size and strength is described and some experimental results are presented.
Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4 (1996)

The herpes simplex virus ICP4 protein is required for induction of early and late viral gene transcription as well as for repression of expression of its own gene and several other viral genes. Several electrophoretic forms of ICP4 have been observed, and phosphorylation is thought to contribute to this heterogeneity and possibly to the multiple functions of ICP4. To define the complexity of the site(s) of phosphorylation of ICP4 and to initiate mapping of this site(s), we have performed two-dimensional phosphopeptide mapping of wild-type and mutant forms of ICP4 labeled in infected cells or in vitro. Wild-type ICP4 labeled in infected cells shows a complex pattern of phosphopeptides, and smaller mutant forms of ICP4 show progressively fewer phosphopeptides, arguing that multiple sites on ICP4 are phosphorylated. The serine-rich region of ICP4, residues 175 to 198, was shown to be a site for phosphorylation. Furthermore, the serine-rich region itself or the phosphorylation of this region increases phosphorylation of all phosphopeptides. A mutant ICP4 molecule lacking the serine-rich region showed low levels of phosphorylation by protein kinase A or protein kinase C in vitro. These results suggest that there may be a sequential phosphorylation of ICP4, with phosphorylation of the serine-rich region stimulating phosphorylation of the rest of the molecule. In addition, purified ICP4 showed an associated kinase activity or an autophosphorylation activity with properties different from those of protein kinase A or protein kinase C.
Processing of Boron Carbide‐Aluminum Composites (1989)

The processing problems associated with boron carbide and the limitations of its mechanical properties can be significantly reduced when a metal phase (e.g., aluminum) is added. Lower densification temperatures and higher fracture toughness will result. Based on fundamental capillarity ther modynamics, reaction thermodynamics, and densification kinetics, we have established reliable criteria for fabricating B 4 C–Al particulate composites. Because chemical reactions cannot be eliminated, it is necessary to process B 4 C–AI by rapidly heating to near 1200°C (to ensure wetting) and subsequently heat‐treating below 1200°C (for microstructural development).
Advances in the Design of Photoinitiators, Photo‐Sensitizers and Monomers for Photoinitiated Cationic Polymerization (2004)

Abstract The present article reports on recent work from this laboratory that has led to advances in several areas of the field of photoinitiated cationic polymerization. Two different classes of novel photoinitiators 5‐arylthianthrenium salts and 4‐hydroxyphenyl dialkylsulfonium salts have been prepared and their use in the polymerization of various monomer systems studied. Also described is the development of both monomeric and polymeric photosensitizers that may be employed to broaden the spectral sensitivity of various onium salt photoinitiators. Acceleration of rate of the ring‐opening polymerization of epoxide monomers has been achieved through the use of benzyl alcohols. Further, benzyl alcohols bearing sensitizing groups were found to be especially interesting as combination accelerators‐photosensitizers. Lastly, epoxy monomers having groups with easily abstractable protons display exceptional reactivity in photoinitiated ring‐opening cationic polymerization. A mechanism has been proposed to explain this observation.
Interactive Depth-Aware Effects for Stereo Image Editing (2013)

This paper introduces methods for adding user-guided depth-aware effects with minimal user interaction to images captured with a consumer-grade stereo camera. In particular, we present methods for highlighted depth-of-field, haze, depth-of-field, and image relighting. Unlike many prior methods for adding such effects, we do not assume prior scene models or require extensive user guidance to create such models, nor do we require multiple images of the scene under different conditions. We also do not require specialized camera rigs or other equipment such as light-field camera arrays, active lighting, etc. Instead, we use only an easily portable and affordable consumer-grade stereo camera. The depth is calculated from a stereo image pair using an extended version of Patch Match Stereo designed to compute not only image disparities but also normals for visible surfaces. We also introduce a pipeline for rendering multiple effects in the order they would occur physically. Each can be added, removed, or adjusted in the pipeline without having to reapply subsequent effects. Individually or in combination, these effects can be used to enhance the sense of depth or structure in images and provide increased artistic control. These effects can be applied to the stereo pair together in a fashion that preserves stereo consistency, or they can be applied to a single image only, thus leveraging the advantages of stereo acquisition even when producing a single photograph.
Templated Collagen “Double Helices” Maintain Their Structure (2020)

The self-assembly of collagen-mimetic peptides (CMPs) that form sticky-ended triple helices has allowed the production of surprisingly stable artificial collagen fibers and hydrogels. Assembly through sticky ends requires the recognition of a single strand by a templated strand dimer. Although CMPs and their triple helices have been studied extensively, the structure of a strand dimer is unknown. Here, we evaluate the physical characteristics of such dimers, using disulfide-templated (PPG)<sub>10</sub> dimers as a model. Such "linked-dimers" retain their collagen-like structure even in the absence of a third strand, but only when their strands are capable of adopting a triple-helical fold. The intrinsic collagen-like structure of templated CMP pairs helps to explain the success of sticky-ended CMP association and changes the conception of new synthetic collagen designs.