gebhart/patrepeval huggingface dataset:
A new look at nonseparable synthetic aperture radar processing (1988)

The author examines the nonseparable, template correlation approach to digital-strip-mode synthetic-aperture radar (SAR) phase history processing and concludes that it can now outperform the traditional separable approaches in the areas of speed, image quality, control simplicity, and flexibility. A working nonseparable frequency-domain SAR processor is described and evaluated. The image quality is seen to be superior to that resulting from the separable approaches. Based on the working intermediate hardware implementation, the author strongly suggests that future VHSIC and other advanced implementation will provide extremely fast (real time), high-quality, small, flexible SAR processors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification of Vibrio anguillarum in fish by using partial 16S rRNA sequences and a specific 16S rRNA oligonucleotide probe (1989)

16S rRNA from seven different Vibrio anguillarum strains was partially sequenced and compared. From this sequence information we could design a 25-base-long oligonucleotide and use it as a specific probe for identification of V. anguillarum. This was determined by RNA-DNA colony hybridization and slot-blot hybridization. Strong, specific hybridization to the probe was observed for all V. anguillarum strains tested. Furthermore, no cross-hybridization could be seen against five other bacterial species. The detection limit was 5 x 10(3) bacteria per ml. It was even possible to detect V. anguillarum, by slot-blot hybridization, directly in a homogenized kidney from a fish that had died of vibriosis. The partial sequence information revealed small but significant differences between strains of the same species. These sequence differences are sufficiently significant to allow serotyping on the RNA level. Comparing strains of different serotypes revealed a 10-base and an 11-base difference in V. anguillarum serotypes O8 and O9, respectively, in a 122-base partial sequence.
Assessing the feasibility of online SSVEP decoding in human walking using a consumer EEG headset (2014)

SSVEP-based BCI systems are deployable to users in treadmill walking that mimics natural walking rather than in highly-controlled laboratory settings. This study considerably promotes the use of a consumer-level EEG headset towards the real-life BCI applications.
Wearable Chemical Sensors: Emerging Systems for On-Body Analytical Chemistry (2019)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTWearable Chemical Sensors: Emerging Systems for On-Body Analytical ChemistryJuliane R. SempionattoJuliane R. SempionattoDepartment of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United StatesMore by Juliane R. SempionattoView Biography, Itthipon JeerapanItthipon JeerapanDepartment of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United StatesMore by Itthipon JeerapanView Biographyhttp://orcid.org/0000-0001-8016-6411, Sadagopan KrishnanSadagopan KrishnanDepartment of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United StatesDepartment of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United StatesMore by Sadagopan KrishnanView Biographyhttp://orcid.org/0000-0002-9968-2712, and Joseph Wang*Joseph WangDepartment of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States*E-mail: [email protected]More by Joseph WangView Biographyhttp://orcid.org/0000-0002-4921-9674Cite this: Anal. Chem. 2020, 92, 1, 378–396Publication Date (Web):October 18, 2019Publication History Published online18 October 2019Published inissue 7 January 2020https://pubs.acs.org/doi/10.1021/acs.analchem.9b04668https://doi.org/10.1021/acs.analchem.9b04668review-articleACS PublicationsCopyright © 2019 American Chemical SocietyRequest reuse permissionsArticle Views9861Altmetric-Citations140LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Biotechnology,Carbohydrates,Sensors,Wearable electronics Get e-Alerts
Cyclooxygenase-2 Inhibition Inhibits c-Met Kinase Activity and Wnt Activity in Colon Cancer (2008)

Activity of receptor tyrosine kinases (RTK) in colorectal cancer (CRC) is associated with enhanced tumor growth and a poorer prognosis. In addition, cyclooxygenase-2 (COX-2) expression contributes to tumor growth and invasion. COX-2 inhibitors exhibit important anticarcinogenic potential against CRC, but the molecular mechanism underlying this effect and the relation with RTK signaling remain the subject of intense research effort. Therefore, the rapid effects of COX-2 inhibition in CRC on the complement of all cellular kinases were investigated using a kinase substrate peptide array, Western blotting, transfection, small interfering RNA assays, and CRC cell lines. The resulting alterations in the kinome profile revealed that celecoxib, a selective COX-2 inhibitor, impairs phosphorylation of substrates for the RTKs c-Met and insulin-like growth factor receptor, resulting in decreased downstream signaling. The decrease in c-Met activation is accompanied with an increase in glycogen synthase kinase 3beta kinase activity together with a rapid increase in phosphorylation of beta-catenin. In agreement, a significant reduction of beta-catenin-T-cell factor-dependent transcription is observed both with celecoxib and selective inhibition of c-Met phosphorylation by small molecules. Hence, corepression of c-Met-related and beta-catenin-related oncogenic signal transduction seems a major effector of celecoxib in CRC, which provides a rationale to use c-Met inhibitors and celecoxib analogous to target c-Met and Wnt signaling in a therapeutic setting for patients with CRC.
On the puncturing patterns for punctured polar codes (2014)

Puncturing is widely used to generate rate-compatible codes. However, for punctured polar codes, some puncturing patterns may greatly affect the split bit channels and cause considerable performance loss. In this paper, we aim to investigate how the split bit channels are affected by various puncturing patterns, and then evaluate the performances of these patterns. We propose a search algorithm to design good punctured polar codes, and prove that designing the optimal puncturing pattern for output bits is equivalent to finding the optimal puncturing pattern for frozen bits. We also propose a heuristic approach based on the idea of polarization to select the position of each punctured output bit, and simulations show that the puncturing pattern designed this way almost achieves the same performance as the optimal one selected by exhaustive search.
Localization of nodes and personnel in a multistatic radar sensor network (2007)

Technology for the detection of enemies from behind barriers and for securing of ports and perimeters with minimal threat to warfighters is essential in modern threat scenarios. We are developing a network of small scattered Doppler radar sensors which lie in wait and report on change or motion within a targeted perimeter. Most sensors are simple radar receiver "nodes" capable of short range communications and long operation life with minimal power requirements, while a few are more advanced radar transceiver "beacons" capable of active interrogation and long range communications. Radar nodes and beacons could be scatter-deployed from a distance, creating a need for post-deployment localization in order to provide useful reconnaissance. A beacon is designed to have absolute position knowledge by strategic deployment of GPS, produces an interrogation signal, and analyzes locally received echoes for signs of motion activity in the targeted area. Scattered nodes in the targeted vicinity form an ad-hoc network which also receives and compares the beacon signal and its target echoes, and reports sensed activity to the beacon. This paper introduces such a system and discusses radar node localization based on signal strength using kernel methods and distributed learning algorithms which take energy constraints into account.
Annual Report July 1, 1976-June 30, 1977 (1977)

William P. Wood, Evan H. Turner, Mrs. Stuart F. Louchheim, Mrs. Robert D. Dripps, Annual Report July 1, 1976-June 30, 1977, Philadelphia Museum of Art Bulletin, Vol. 73, No. 319, Annual Report July 1, 1976-June 30, 1977 (Dec., 1977), pp. 1-27+42-49
Redox Mediators in Visible Light Photocatalysis: Photocatalytic Radical Thiol–Ene Additions (2014)

Synthetically useful radical thiol-ene reactions can be initiated by visible light irradiation in the presence of transition metal polypyridyl photocatalysts. The success of this method relies upon the use of p-toluidine as an essential additive. Using these conditions, high-yielding thiol-ene reactions of cysteine-containing biomolecules can be accomplished using biocompatibile wavelengths of visible light, under aqueous conditions, and with the thiol component as the limiting reagent. We present evidence that p-toluidine serves as a redox mediator that is capable of catalyzing the otherwise inefficient photooxidation of thiols to the key thiyl radical intermediate. Thus, we show that co-catalytic oxidants can be important in the design of synthetic reactions involving visible light photoredox catalysis.
Dual flaA1 flaB1 mutant of Serpulina hyodysenteriae expressing periplasmic flagella is severely attenuated in a murine model of swine dysentery (1996)

The motility imparted by the periplasmic flagella (PF) of Serpulina hyodysenteriae is thought to play a pivotal role in the enteropathogenicity of this spirochete. The complex PF are composed of multiple class A and class B polypeptides. Isogenic strains containing specifically disrupted flaAl or flaB1 alleles remain capable of expressing PF, although such mutants display aberrant motility in vitro. To further examine the role that these proteins play in the maintenance of periplasmic flagellar structural integrity, motility, and fitness for intestinal colonization, we constructed a novel strain of S. hyodysenteriae which is deficient in both FlaA1 and FlaB1. To facilitate construction of this strain, a chloramphenicol gene cassette, with general application as a selectable marker in prokaryotes, was developed. The cloned flaAl and flaB1 genes were disrupted by replacement of internal fragments with chloramphenicol and kanamycin gene cassettes, respectively. The inactivated flagellar genes were introduced into S. hyodysenteriae, and allelic exchange at the targeted chromosomal flaA1 and flaB1 loci was verified by PCR analysis. Immunoblots or cell lysates with antiserum raised against purified FlaA or FlaB confirmed the absence of the corresponding sheath and core proteins in this dual flagellar mutant. These mutations selectively abolished the expression of the targeted genes without affecting the synthesis of other immunologically related FlaB proteins. The resulting flaA1 flaB1 mutant exhibited altered motility in vitro. Surprisingly, it was capable of assembling periplasmic flagella that were morphologically normal as evidenced by electron microscopy. The virulence of this strain was assessed in a murine model of swine dysentery by determining the incidence of cecal lesions and the persistence of S. hyodysenteriae in the gut. Mice challenged with the wild-type strain or a passage control strain showed a dose-related response to the challenge organism. The dual flagellar mutant was severely attenuated in murine challenge experiments, suggesting that the FlaA1 and FlaB1 proteins are dispensable for flagellar assembly but critical for normal flagellar function and colonization of mucosal surfaces of the gastrointestinal tract. This strain represents the first spirochete engineered to contain specifically defined mutations in more than one genetic locus.
Angiotensin II Induces Interleukin-1β–Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive Effects (2014)

Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin secretion. However, the direct effects of angiotensin II on islet function and underlying mechanisms independent of changes in blood pressure remain unclear. Here we show that exposure of human and mouse islets to angiotensin II induces interleukin (IL)-1-dependent expression of IL-6 and MCP-1, enhances β-cell apoptosis, and impairs mitochondrial function and insulin secretion. In vivo, mice fed a high-fat diet and treated with angiotensin II and the vasodilator hydralazine to prevent hypertension showed defective glucose-stimulated insulin secretion and deteriorated glucose tolerance. Application of an anti-IL-1β antibody reduced the deleterious effects of angiotensin II on islet inflammation, restored insulin secretion, and improved glycemia. We conclude that angiotensin II leads to islet dysfunction via induction of inflammation and independent of vasoconstriction. Our findings reveal a novel role for the RAS and an additional rationale for the treatment of type 2 diabetic patients with an IL-1β antagonist.
Comparison of 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide Based Strategies to Crosslink Antibodies on Amine-Functionalized Platforms for Immunodiagnostic Applications (2012)

1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) alone, and in combination with N-hydroxysuccinimide (NHS) or sulfoNHS were employed for crosslinking anti-human fetuin A (HFA) antibodies on 3-aminopropyltriethoxysilane (APTES)-functionalized surface plasmon resonance (SPR) gold chip and 96-well microtiter plate. The SPR immunoassay and sandwich enzyme linked immunosorbent immunoassay (ELISA) for HFA clearly demonstrated that EDC crosslinks anti-HFA antibodies to APTES-functionalized bioanalytical platforms more efficiently than EDC/NHS and EDC/sulfoNHS at a normal pH of 7.4. Similar results were obtained by sandwich ELISAs for human Lipocalin-2 and human albumin, and direct ELISA for horseradish peroxidase. The more efficient crosslinking of antibodies by EDC to the APTES-functionalized platforms increased the cost-effectiveness and analytical performance of our immunoassays. This study will be of wide interest to researchers developing immunoassays on APTES-functionalized platforms that are being widely used in biomedical diagnostics, biosensors, lab-on-a-chip and point-of-care-devices. It stresses a critical need of an intensive investigation into the mechanisms of EDC-based amine-carboxyl coupling under various experimental conditions.
The Chemistry and Tumoricidal Activity of Nitric Oxide/Hydrogen Peroxide and the Implications to Cell Resistance/Susceptibility (1996)

The mechanism of cytotoxicity of the NO donor 3-morpholino-sydnonimine toward a human ovarian cancer cell line (OVCAR) was examined. It was found that the NO-mediated loss of cell viability was dependent on both NO and hydrogen peroxide (H2O2). Somewhat surprisingly, superoxide (O2) and its reaction product with NO, peroxynitrite (-OONO), did not appear to be di- rectly involved in the observed NO-mediated cytotoxicity against this cancer cell line. The toxicity of NO/H2O2 may be due to the production of a potent oxidant formed via a trace metal-, H202-, and NO-dependent process. Because the combination of NO and H2O2 was found to be particularly cytotoxic, the effect of NO on cellular defense mechanisms involving H2O2 degradation was investigated. It was found that NO was able to inhibit catalase activity but had no effect on the activity of the glutathione peroxidase (GSHPx)-glutathione reductase system. It might therefore be expected that cells that utilize primarily the GSHPx-glutathione reductase system for degrading H2O2 would be somewhat resistant to the cytotoxic effects of NO. Consistent with this idea, it was found that ebselen, a compound with GSHPx-like activity, was able to protect cells against NO toxicity. Also, lowering endogenous GSHPx activity via selenium depletion resulted in an increased susceptibility of the target cells to NO-mediated toxicity. Thus, a possible NO/H2O2/metal-mediated mechanism for cellular toxicity is presented as well as a possible explanation for cell resistance/susceptibility to this NO-initiated process.
Exploration of Schemes for Authenticated Key Agreement Protocol Based on Elliptic Curve Cryptosystem (2013)

Wireless technology has become more persistent with wide demand of mobile devices such as personal digital assistance, smart phones and laptops. The elliptic curve cryptography(ECC) techniques provide greater security using fewer bits resulting in a protocol which requires low computational and communication overhead, therefore suitable for wireless communication system as well as wireless communication devices smart cards, PDAs and other handheld devices. These systems are prone to eavesdropping due to easy access to free space medium. In such cases, appropriate authenticity and cryptographic procedures need to be adopted for reliable and secure communication. Key agreement protocol based on elliptic curve cryptography suited for wireless network. This paper describes various schemes used for implementation of authenticated key agreement protocol in wireless network.
Local Rules for Global MAP: When Do They Work? (Technical Report) (2009)

We consider the question of computing Maximum A Posteriori (MAP) assignment in an arbitrary pair-wise Markov Random Field (MRF). We present a randomized iterative algorithm based on simple local updates. The algorithm, starting with an arbitrary initial assignment, updates it in each iteration by first, picking a random node, then selecting an (appropriately chosen) random local neighborhood and optimizing over this local neighborhood. Somewhat surprisingly, we show that this algorithm finds a near optimal assignment within n log2 n iterations with high probability for any n node pair-wise MRF with geometry (i.e. MRF graph with polynomial growth) with the approximation error depending on (in a reasonable manner) the geometric growth rate of the graph and the average radius of the local neighborhood – this allows for a graceful tradeoff between the complexity of the algorithm and the approximation error. Through extensive simulations, we show that our algorithm finds extremely good approximate solutions for various kinds of MRFs with geometry.
Highly Efficient Reversible Hydrogenation of Carbon Dioxide to Formates Using a Ruthenium PNP‐Pincer Catalyst (2014)

Abstract The use of hydrogen as a fuel requires both safe and robust technologies for its storage and transportation. Formic acid (FA) produced by the catalytic hydrogenation of CO 2 is recognized as a potential intermediate H 2 carrier. Herein, we present the development of a formate‐based H 2 storage system that employs a Ru PNP‐pincer catalyst. The high stability of this system allows cyclic operation with an exceptionally fast loading and liberation of H 2 . Kinetic studies highlight the crucial role of the base promoter, which controls the rate‐determining step in FA dehydrogenation and defines the total H 2 capacity attainable from the hydrogenation of CO 2 . The reported findings show promise for the development of practical technologies that use formic acid as a hydrogen carrier.
Dendritic cells treated with chloroquine modulate experimental autoimmune encephalomyelitis (2013)

Chloroquine (CQ), an antimalarial drug, has been shown to modulate the immune system and reduce the severity of experimental autoimmune encephalomyelitis (EAE). The mechanisms of disease suppression are dependent on regulatory T cell induction, although Tregs-independent mechanisms exist. We aimed to evaluate whether CQ is capable to modulate bone marrow-derived dendritic cells (DCs) both phenotypically and functionally as well as whether transfer of CQ-modulated DCs reduces EAE course. Our results show that CQ-treated DCs presented altered ultrastructure morphology and lower expression of molecules involved in antigen presentation. Consequently, T cell proliferation was diminished in coculture experiments. When transferred into EAE mice, DC-CQ was able to reduce the clinical manifestation of the disease through the modulation of the immune response against neuroantigens. The data presented herein indicate that chloroquine-mediated modulation of the immune system is achieved by a direct effect on DCs and that DC-CQ adoptive transfer may be a promising approach for avoiding drug toxicity.
Polymorphisms of<i>EDNRB</i>,<i>ATG</i>, and<i>ACE</i>genes in salt-sensitive hypertensionThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin. (2008)

Almost 50% of hypertensive individuals manifest blood pressure changes in response to salt depletion or repletion and are termed "salt sensitive" (SS). Blunted activity of the endothelin (ET) system and the renin-angiotensin-aldosterone system (RAAS) have been reported as possible mechanisms contributing to salt sensitivity. Data are available that endothelin receptor subtype B (ETBR)-deficient rats develop salt-sensitive hypertension when fed a high-salt diet. Whether the ETBR gene (EDNRB) is involved in genetic predisposition to human salt-sensitive hypertension has not been studied so far. We screened EDNRB in 104 hypertensive patients (49 salt sensitive and 55 salt resistant) and 110 normotensive controls. No new sequence variation was found, but genotype distribution of the common polymorphism G1065A revealed that the AA + GA genotypes were significantly more frequent in salt-resistant than in salt-sensitive individuals (p = 0.007), suggesting a protective role for the A allele. We also screened angiotensinogen gene AGT M235T and angiotensin-converting enzyme insertion/deletion polymorphism ACE I/D and found an association between TT genotype and hypertension. A possible synergistic effect to salt-sensitive hypertension was found by combining EDNRB GG with ACE DD/ID genotypes. In conclusion, our data confirm the role of ET system and RAAS in salt-sensitive hypertension.