gebhart/patrepeval huggingface dataset:
The mitochondrial DNA polymerase as a target of oxidative damage (2002)

The mitochondrial respiratory chain is a source of reactive oxygen species (ROS) that are responsible for oxidative modification of biomolecules, including proteins. Due to its association with mitochondrial DNA, DNA polymerase gamma (pol gamma) is in an environment to be oxidized by hydrogen peroxide and hydroxyl radicals that may be generated in the presence of iron ions associated with DNA. We tested whether human pol gamma was a possible target of ROS with H2O2 and investigated the effect on the polymerase activities and DNA binding efficiency. A 1 h treatment with 250 microM H2O2 significantly inhibited DNA polymerase activity of the p140 subunit and lowered its DNA binding efficiency. Addition of p55 to the p140 catalytic subunit prior to H2O2 treatment offered protection from oxidative inactivation. Oxidatively modified amino acid residues in pol gamma resulting from H2O2 treatment were observed in vitro as well as in vivo, in SV40-transfected human fibroblasts. Pol gamma was detected as one of the major oxidized mitochondrial matrix proteins, with a detectable decline in polymerase activity. These results suggest pol gamma as a target of oxidative damage, which may result in a reduction in mitochondrial DNA replication and repair capacities.
An experimental study on improvement of Savonius rotor performance (2012)

For solving the world energy problem and the bad effect of conventional sources of energy on environment, great attention allover the world is paid towards the use of renewable energy sources. Special interest is paid towards wind energy because of its competitively. Savonius rotor is a vertical axis wind turbine which is characterized as cheaper, simpler in construction and low speed turbine. This makes it suitable for generating mechanical energy in many countries especially in Egypt. In this work different geometries of Savonius wind turbine are experimentally studied in order to determine the most effective operation parameters. It was found that, the two blades rotor is more efficient than three and four ones. The rotor with end plates gives higher efficiency than those of without end plates. Double stage rotors have higher performance compared to single stage rotors. The rotors without overlap ratio (β) are better in operation than those with overlap. The results show also that the power coefficient increases with rising the aspect ratio (α). The conclusions from the measurements of the static torque for each rotor at different wind speeds verify the above summarized results of this work.
Methods compared for determining glutathione peroxidase activity in blood. (1987)

We compared four methods for determination of glutathione peroxidase (EC 1.11.1.9) activity, using blood samples from 52 healthy volunteers. Two methods depended on direct assay of the amount of glutathione remaining at specific time intervals; the two indirect methods involved measuring the rate of disappearance of NADPH. We assessed the precision and reproducibility of each method. One of the indirect assays proved to be far superior to the other methods. Results of each of the methods were correlated with one another. We present the normal reference intervals for glutathione peroxidase activity for all four methods.
Reactions of substituted hydrazines with glyoxal (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of substituted hydrazines with glyoxalRobert R. GallucciCite this: J. Chem. Eng. Data 1982, 27, 2, 217–219Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/je00028a036https://doi.org/10.1021/je00028a036research-articleACS PublicationsRequest reuse permissionsArticle Views863Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On backhaul-constrained multi-cell cooperative detection based on superposition coding (2008)

A continuously increasing demand for higher spectral efficiencies in mobile communications will require next generation cellular systems to employ a very dense reuse of spectrum in combination with smart interference mitigation or cancellation schemes. Recent publications have revealed a large potential in terms of spectral efficiency and system fairness of multi-cell cooperative schemes, where e.g. multiple base stations jointly receive or transmit signals connected to multiple terminals. The downside of these schemes is typically the large extent of backhaul link capacity required between base stations. In this paper, we focus on the cellular uplink and investigate the information theoretical limits of multi-cell cooperation under a constrained backhaul. We propose a framework that allows to observe different forms of cooperation between base stations in combination with superposition coding, revealing non-negligible performance improvements compared to our previous results.
The greater wax moth<i>Galleria mellonella</i>: biology and use in immune studies (2020)

The greater wax moth Galleria mellonella is an invertebrate that is increasingly being used in scientific research. Its ease of reproduction, numerous offspring, short development cycle, and finally, its known genome and immune-related transcriptome provide a convenient research model for investigation of insect immunity at biochemical and molecular levels. Galleria immunity, consisting of only innate mechanisms, shows adaptive plasticity, which has recently become the subject of intensive scientific research. This insect serves as a mini host in studies of the pathogenicity of microorganisms and in vivo tests of the effectiveness of single virulence factors as well as new antimicrobial compounds. Certainly, the Galleria mellonella species deserves our attention and appreciation for its contribution to the development of research on innate immune mechanisms. In this review article, we describe the biology of the greater wax moth, summarise the main advantages of using it as a model organism and present some of the main techniques facilitating work with this insect.
Crosspolarization coupling measured for 800 MHz radio transmission in and around houses and large buildings (1985)

The scatter and reflectors that produce multipath propagation in the portable radiotelephone environment also scatter energy from the transmitted polarization into the orthogonal polarization. This crosspolarization coupling improves the signal quality on portable radio links by mitigating the effects of random antenna orientation and by providing an additional signal path for diversity combining. Measurements were made of crosspolarization coupling at 800 MHz within and around eight suburban houses and within two commercial buildings. Nearly complete coupling between polarization was seen for all propagation paths except for a few residential paths having high copolarized was seen for all propagation paths except for a few residential paths having high copolarized signal levels. Because of the high crosspolarization coupling, random orientation of portable radio sets will not cause significant degradation of signal quality.
Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases (2021)

Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used to transduce autologous somatic cells, obtained from patients and re-delivered to patients after transduction. Examples are hematopoietic stem cells used in gene therapy for hematological or neurometabolic diseases or T cells for immunotherapy of cancer. We review the design and use of lentiviral vectors in gene therapy of monogenic diseases, with a focus on controlling gene expression by transcriptional or post-transcriptional mechanisms in the context of vectors that have already entered a clinical development phase.
A preliminary study of a robotic probe for soil exploration inspired by plant root apexes (2008)

Plants are organisms characterized by an aerial part and a root system. Plants have developed directional growth responses to deal with the copious and rapid changes in their environment in order to compensate for their sessile nature. The process by which plant roots expand in soil involves water uptake through osmosis and imbibition, and an overall increase in size by cell division. Each root tip (apex) has sensors to get information from the environment, which is then transduced, processed, and used to direct the growth towards regions of the soil with the best minerals and water availability. This knowledge has inspired a novel concept of robotic system, leading to a first mechanical design and prototype of a steering tip inspired by plant apexes, based on a new actuation biologically inspired osmotic principle. A parametric model of the system geometry has been developed and presented here, in order to obtain an optimal size of the robotic system and to achieve the best compromise between steering performance and actuation times. First prototypes of the robotic apex have been fabricated by a 3D printer InVision si2, with a plastic material, including osmotic actuators, gravity and humidity sensors, and the electronics for sensory data acquisition and steering control.
Spatio-temporal variations of vehicle traffic in VANETs (2009)

Via statistical analysis of several sets of empirical data collected from realistic scenarios, we realize that exponential model is a good fit for highway vehicle traffic. This model provides a single parameter (the exponent of vehicle density λs) to describe traffic variation. We reveal that highway traffic drastically varies over time (of different scales), across geographic locations and over technology adoption phases. Considering multi-hop geocast and single-hop broadcast, we show via both mathematical analysis and simulations the performance of path availability in the former, and packet delivery ratio in the latter, with respect to short- and long-term traffic variation.
개념도 방법론을 활용한 재정착난민 수용태도에 관한 연구: 자원활동가를 중심으로 (2018)

본 연구는 자원활동가들이 재정착난민을 어떻게 인식하고 어떤 차원에 인지하고 있는지에 관한 수용태도를 밝히고 추출된 요인들 간의 연관성을 탐색하는데 목적을 두었다. 이를 위해 본 연구는 인천지역에 거주 중인 자원활동가 10명을 대상으로 개별 심층면접을 하고 차원과 군집을 분류하는 개념도(concept map) 연구방법을 적용하여 총 73개의 진술문과 7개 군집으로 수용태도 인식의 주요차원을 밝혔다. 분석결과 군집별로 맥락을 보면 진술문 59개는 대부분 긍정적이고, 일부는 동정과 두려움으로 긍정과 부정이 혼재된 수용적 표현이었으나, 남은 진술문 14개는 부정적인 표현이 진술 되었다. 이는 난민의 기본적 권리는 존중하나 그 권리를 동등하게 인정하지 못하는 긍정과 부정의 이중성이 있음이 파악 되었다. 연구결과를 바탕으로 향후 수용태도의 개선을 위한 연구방법과 교육정책을 전반적으로 점검해야 될 시점에 대한 정책적 제언을 하였다.
Microbial transformation of racemic hydantoins to <scp>D</scp>‐amino acids (1981)

Abstract It has been shown that resting cells of Agrobacterium radiobacter catalyze a sequence of two stereospecific hydrolytic reactions leading to the complete transformation of racemic hydantoins to D ‐amino acids. This report describes some properties of this new biocatalyst and its potential application for the production of some D ‐amino acids, which are used as intermediates in the preparation of semisynthetic penicillin and cephalosporins.
Phase reconstruction of spectrograms with linear unwrapping: Application to audio signal restoration (2015)

This paper introduces a novel technique for reconstructing the phase of modified spectrograms of audio signals. From the analysis of mixtures of sinusoids we obtain relationships between phases of successive time frames in the Time-Frequency (TF) domain. To obtain similar relationships over frequencies, in particular within onset frames, we study an impulse model. Instantaneous frequencies and attack times are estimated locally to encompass the class of non-stationary signals such as vibratos. These techniques ensure both the vertical coherence of partials (over frequencies) and the horizontal coherence (over time). The method is tested on a variety of data and demonstrates better performance than traditional consistency-based approaches. We also introduce an audio restoration framework and observe that our technique outperforms traditional methods.
Single-Stage Boost Inverter With Coupled Inductor (2011)

Renewable power systems as distributed generation units often experience big changes in the inverter input voltage due to fluctuations of energy resources. Often, a front-end boost converter is added to step up the dc voltage when the energy resources are at a weak point. However, when a very high boost gain is demanded, the duty cycle may come to its extreme, and large duty cycles causes serious reverse-recovery problems. This paper proposes a novel single-stage boost-type inverter with coupled inductor. By introducing impedance network, including coupled inductor, into the three-phase bridge inverter, and adjusting the previously forbidden shoot-through zero state, the converter can realize a high boost gain and output a stable ac voltage. The single-stage operation of the converter may lead to improved reliability and higher efficiency. Theoretical analysis, simulation, and experimental results are presented to verify good performance.
New Organo-Lewis Acids. Tris(β-perfluoronaphthyl)borane (PNB) as a Highly Active Cocatalyst for Metallocene-Mediated Ziegler−Natta α-Olefin Polymerization (1998)

Tris(β-perfluoronaphthyl)borane (B(C10F7)3, PNB) is synthesized from β-perfluoronaphthyllithium and BCl3 to serve as a new strong organo-Lewis acid cocatalyst. PNB efficiently activates a variety of group 4 dimethyl complexes to form highly active homogeneous Ziegler−Natta olefin polymerization catalysts. Reaction of PNB with rac-Me2Si(Ind)2ZrMe2 and CGCMMe2 (M = Zr, Ti; CGC = Me2Si(η5-Me4C5)(tBuN)) (1:1 molar ratio) rapidly produces the base-free cationic complexes rac-Me2Si(Ind)2ZrMe+MePNB- (1) and CGCMMe+MePNB- (M = Zr, 2; Ti, 3), respectively. The μ-methyl dinuclear cationic complex [(CGCTiMe)2(μ-Me)]+MePNB- (4) is formed when a 2:1 CGCTiMe2:PNB stoichiometry is employed. In the case of group 4 dimethyl zirconocenes, L2ZrMe2 (L = η5-C5H5, Cp; η5-1,2-Me2C5H3, Cp‘‘), reaction in a 1:1 metallocene:PNB ratio affords cationic complexes L2ZrMe+MePNB- (L = Cp, 5; Cp‘‘, 6), while the reaction with a 1:2 molar ratio affords dinuclear μ-methyl cationic complexes [(L2ZrMe)2(μ-Me)]+MePNB- (L = Cp, 7; Cp‘‘, 8). In both reactions, μ-F dinuclear cationic complexes [(L2ZrMe)2(μ-F)]+MePNB- (L = Cp, 9; Cp‘‘, 10) are formed as byproducts. (C6F5)3BNCCH3 and PNBNCCH3 were synthesized and characterized. Analysis of the PNBNCCH3 + B(C6F5)3 ⇌ (C6F5)3BNCCH3 + PNB equilibrium yields ΔH° = +0.7(2) kcal/mol and ΔS° = +4.3(5) eu, suggesting PNB has somewhat higher Lewis acidity and is sterically more encumbered than B(C6F5)3. Solution ν(CN) values for PNBNCCH3 and (C6F5)3BNCCH3 are 2365.3 and 2366.5 cm-1, respectively, which indicate strong Lewis acidity. PBBNCCH3 cannot be detected in the reaction of (C6F5)3BNCCH3 with PBB [PBB = tris(2,2‘,2‘‘-perfluorobipheny)lborane] over prolonged periods at 60 °C. In ethylene polymerization, PNB-derived cationic complexes 5, 6, 7, and 8 have catalytic activities similar to the B(C6F5)3-derived analogues, while 2 and 3 have substantially higher activities. In propylene polymerization, catalyst 1 has higher activity than the B(C6F5)3 analogue. In the case of ethylene and 1-hexene copolymerization, PNB-derived cationic complex 3 exhibits higher polymerization activity with similar 1-hexene incorporation versus the B(C6F5)3-derived cationic complex. In large-scale batch copolymerizations of ethylene and 1-octene mediated by CGCTiMe2, the PNB-based catalytic systems exhibit approximately twice the activity of the B(C6F5)3-based systems.
ChemInform Abstract: The Homochiral versus Heterochiral Packing Dilemma (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Color image feature extraction using color index local auto-correlations (2009)

In this paper, we propose a method for extracting color image features, called color index local auto-correlations. Pixel color is quantized and described sparsely in a manner similar to the color indexing of color histograms. In addition, by utilizing spatial auto-correlations of the color indexes, the characteristics of color texture can be extracted more effectively than ordinary histogram-based methods. The proposed method has variants in terms of the color space and basic colors used for indexing colors. These various settings are comprehensively compared in the experiments of image retrieval and image classification, and are shown to exhibit favorable results compared to the other conventional methods.
Aborted Off-Pump Coronary Artery Bypass Patients Have Much Worse Outcomes Than On-Pump or Successful Off-Pump Patients (2005)

Patients who are intended for an off-pump strategy and then require conversion to on-pump have significantly higher operative mortality and morbidity than either completed OPCAB or CPB patients. In addition, the operative mortality and morbidity are far in excess of that predicted preoperatively. Based on these results, strong consideration should be given for a planned strategy of CPB for those patients with preoperative hemodynamic instability requiring a salvage CABG operation, left ventricular hypertrophy, or previous CABG.
A Fast and Accurate Position Sensitive Timing Detector Based on Secondary Electron Emission (1999)

Abstract A position-sensitive timing detector suitable for detection of low-energy heavy ions is described. The device is based on the detection of secondary electrons emitted following ion impact on a surface. Using a combination of magnetic and electric fields these devices can deliver sub-nanosecond time definition and sub-millimeter position information for ion impact even at incidence rates above 10 6 p / s . When choosing a thin foil for the surface intercepting the heavy ion trajectory, multiple detectors can be used and reliable tracking of heavy ions with moderate energies (≥1 MeV / A ) becomes feasible.
Smart-Phones Attacking Smart-Homes (2016)

The explosion in Internet-connected household devices, such as light-bulbs, smoke-alarms, power-switches, and webcams, is creating new vectors for attacking "smart-homes" at an unprecedented scale. Common perception is that smart-home IoT devices are protected from Internet attacks by the perimeter security offered by home routers. In this paper we demonstrate how an attacker can infiltrate the home network via a doctored smart-phone app. Unbeknownst to the user, this app scouts for vulnerable IoT devices within the home, reports them to an external entity, and modifies the firewall to allow the external entity to directly attack the IoT device. The ability to infiltrate smart-homes via doctored smart-phone apps demonstrates that home routers are poor protection against Internet attacks and highlights the need for increased security for IoT devices.
Historical developments (2013)

Our assessment of the new curriculm moves on to history. The DfE have certainly listened to debate and there are laudable aims, but it is still a lot to get through.
Selective tuning of high-Q silicon photonic crystal nanocavities via laser-assisted local oxidation (2011)

We examine the cavity resonance tuning of high-Q silicon photonic crystal heterostructures by localized laser-assisted thermal oxidation using a 532 nm continuous wave laser focused to a 2.5 μm radius spot-size. The total shift is consistent with the parabolic rate law. A tuning range of up to 8.7 nm is achieved with ∼ 30 mW laser powers. Over this tuning range, the cavity Qs decreases from 3.2×10(5) to 1.2×10(5). Numerical simulations model the temperature distributions in the silicon photonic crystal membrane and the cavity resonance shift from oxidation.
Design and Implementation of Three-Dimensional Virtual Tour Guide Training System Based on Unity3D (2019)

Traditional tour guide training has problems such as lack of internship resources, insufficient time and funds, and safety. How to scientifically and effectively improve the professional quality of tour guides and obtain greater economic and social benefits for tourism has become an urgent problem to be solved. In order to effectively solve the above problems, this paper designed and developed a virtual tour guide training system by using Unity3D interactive development engine and 3ds Max 3d modeling technology. It has the characteristics of autonomy, sense of immersion, interactivity and so on. It provides the trainers with a high simulation scenario and a good training environment of interactivity, which can improve the training quality.
Grating Lobe Mitigation in Scanning Planar Phased Array Antennas (2019)

This paper presents the grating lobe reduction in a planar phased array antenna with a rectangular lattice and large element spacing in the order of one wavelength for scan angles up to ±45°. A dual-mode circular microstrip patch antenna is considered as the constitutive element of the phased array, in which two different transverse magnetic modes are exploited simultaneously. The numerical analysis shows that the achieved grating lobe reduction is well below 25 dB for scan angles up to ±45° with large element spacing in the order of one wavelength.
Discovery of Multifold Modified Sialosides as <i>Human</i> CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells (2014)

Sialic acids are abundant in higher domains of life and lectins recognizing sialosaccharides are heavily involved in the regulation of the human immune system. Modified sialosides are useful tools to explore the functions of those lectins, especially members of the Siglec (sialic acid binding immunoglobulin like lectin) family. Here we report design, synthesis, and affinity evaluation of novel sialoside classes with combined modification at positions 2, 4, and 9 or 2, 3, 4, and 9 of the sialic acid scaffold as human CD22 (human Siglec-2) ligands. They display up to 7.5 × 10(5)-fold increased affinity over αMe Neu5Ac (the minimal Siglec ligand). CD22 is a negative regulating coreceptor of the B-cell receptor (BCR). In vitro experiments with a human B-lymphocyte cell line showed functional blocking of CD22 upon B-cell receptor (BCR) stimulation in the presence of nanomolar concentrations of the novel ligands. The observed increased Ca(2+) response corresponds to enhanced cell activation, providing an opportunity to therapeutically modulate B-lymphocyte responses, e.g., in immune deficiencies and infections.