gebhart/patrepeval huggingface dataset:
Deletion of Aryl Hydrocarbon Receptor AHR in Mice Leads to Subretinal Accumulation of Microglia and RPE Atrophy (2014)

The Ahr(-/-) mice exhibited subretinal accumulation of microglia and focal RPE atrophy, phenotypes observed in AMD. Together with a recently published report on another Ahr(-/-) mouse model, our study suggests that AHR has a protective role in the retina as an environmental stress sensor. As such, its altered function may contribute to human AMD progression and provide a target for pharmacological intervention.
Implementation of high-resolution time-to-digital converter in 8-bit microcontrollers (2012)

This paper will demonstrate how a time-to-digital converter (TDC) with sub-nanosecond resolution can be implemented into an 8-bit microcontroller using so called "direct" methods. This means that a TDC is created using only five bidirectional digital input-output-pins of a microcontroller and a few passive components (two resistors, a capacitor, and a diode). We will demonstrate how a TDC for the range 1-10 μs is implemented with 0.17 ns resolution. This work will also show how to linearize the output by combining look-up tables and interpolation.
DOA estimation for coherent sources in beamspace using spatial smoothing (2004)

Beamspace MUSIC (multiple signal classification) algorithm is often used to solve the DOA (direction of arrival) estimation problem to take advantage of the benefits of beamspace operations, such as reduced computation complexity, reduced sensitivity to system errors, reduced resolution threshold, reduced bias in the estimate, and so on. However, this method will fail to work properly when the source signals are coherent or strongly correlated, which are often encountered in sonar or radar environment. This paper uses the forward-backward spatial smoothing technique as the preprocessor of beamspace MUSIC for linear arrays, after which the coherence of the source signals can be removed in the covariance matrix. We show by computer simulation that the resolution of DOA estimation using beamspace MUSIC after spatial smoothing is better than using element space MUSIC after spatial smoothing. We also show that the beamspace MSUIC using spatial smoothing is more robust than element space MUSIC when there are system errors in the linear array.
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates (1979)

We have used a modification of the Berk-Sharp technique to determine that the 5' termini of the mouse 15 S beta-globin precursor and the mature mRNA have identical map coordinates. The modification involves the use of 5' (or 3') terminally labeled probes; it allows the detection of the precursor in the presence of excess mature mRNA.
Rf coupling analysis via wire penetrating into an aperture (2014)

A metallic enclosure is used to provide effective radio frequency (RF) shielding for electronic circuits. However presence of apertures and wire penetrations in the enclosure degrades the Shielding effectiveness. The study of external electromagnetic coupling vi a wire penetration to elements inside a shielding enclosure have been performed in this paper. Two cases of coupling to a wire segment and a PCB present within the box have been considered. For external fields a plane wave and electromagnetic pulse (EMP) are used. The Computational Electromagnetic modelling is done using a software package.
Electrochemical Detection of Glutathione Using Redox Indicators (2006)

The nucleophilic addition of the aminothiols homocysteine (HCY), cysteine (CYS), and glutathione (GSH) to the electrogenerated quinone of fluorone black (1) via the ECE mechanism is reported. It is demonstrated that 1selectively reacts with GSH to form the bis-GSH adduct, 1-(GSH)(2), while only the monothiol adducts were generated in the presence of HCY and CYS (1-HCY and 1-CYS, respectively). The more anodic E(pa) of 1-(GSH)2 relative to 1 and 1-GSH (DeltaE(pa) approximately +0.14) is the voltammetric signature that allows the discrimination of GSH from HCY and CYS. It is also shown that the presence of structurally similar aminothiols-HCY and CYS-posed no interference to the signature voltammetric response of 1-(GSH)2.
SwiftAnalytics: Optimizing Object Storage for Big Data Analytics (2017)

Due to their scalability and low cost, object-based storage systems are an attractive storage solution and widely deployed. To gain valuable insight from the data residing in object storage but avoid expensive copying to a distributed filesystem (e.g. HDFS), it would be natural to directly use them as a storage backend for data-parallel analytics frameworks such as Spark or MapReduce. Unfortunately, executing data-parallel frameworks on object storage exhibits severe performance problems, reducing average job completion times by up to 6.5×. We identify the two most severe performance problems when running data-parallel frameworks on the OpenStack Swift object storage system in comparison to the HDFS distributed filesystem: (i) the fixed mapping of object names to storage nodes prevents local writes and adds delay when objects are renamed, (ii) the coarser granularity of objects compared to blocks reduces data locality during reads. We propose the SwiftAnalytics object storage system to address them: (i) it uses locality-aware writes to control an object's location and eliminate unnecessary I/O related to renames during job completion, speeding up analytics jobs by up to 5.1×, (ii) it transparently chunks objects into smaller sized parts to improve data-locality, leading to up to 3.4× faster reads.
Effects of administration of α-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activity (2000)

Male hamsters were fed on semi-synthetic diets containing commercial corn oil (CO), isolated corn oil triglycerides (COTG), COTG supplemented with 30 ppm of alpha-tocopherol (COTGTL) and COTG supplemented with 81 ppm of alpha-tocopherol (COTGTH) as the dietary lipid for 45 days. Male albino guinea pigs were fed on commercial chow pellets and treated with different dosages of tocopherol and tocotrienols intra-peritoneally for 6 consecutive days. Serum and liver were taken for analysis. Our results show that stripping corn oil of its unsaponifiable components resulted in COTG which yielded lower serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and raised high-density lipoprotein cholesterol (HDL-C) and serum triglycerides (TG) levels. These results indicate that the COTG with its fatty acids are responsible for the hypocholesterolemic effect exhibited by corn oil. However, supplementing the COTG diet with alpha-tocopherol (alpha-T) at 30 ppm significantly raised the serum TC, LDL-C and TG levels, but did not alter the HDL-C level, indicating that alpha-T is hypercholesterolemic. Supplementing the COTG diet with alpha-T at 81 ppm raised the serum TC level but to a lesser extent as compared to that obtained with 30-ppm alpha-T supplementation. The increased TC, in this case, was reflected mainly by an increased in HDL-C level as the LDL-C level was unchanged. The TG level was also raised but to a lesser extent than that obtained with a lower alpha-T supplementation. The liver HMG CoA reductase (HMGCR) activity was exhibited (56%) by the COTG as compared to CO. Supplementation of alpha-T at 30 ppm to the COTG diet resulted in further inhibition (76%) of the liver HMGCR activity. On the contrary, supplementation of alpha-T at 81 ppm to COTG diet resulted in a highly stimulatory effect (131%) on the liver HMGCR activity. Short-term studies with guinea pigs treated intra-peritoneally with alpha-T showed that at low dosage (5 mg) the HMGCR activity was inhibited by 46% whereas increasing the dosage of alpha-T to 20 mg yielded lesser inhibition (18%) as compared to that of the control. Further increase in the dosage of alpha-T to 50 mg actually resulted in 90% stimulation of the liver HMGCR activity as compared to the control. These results clearly indicate that the effect of alpha-T on HMGCR activity was dose-dependent. Treatment of the guinea pigs with 10 mg of tocotrienols (T3) resulted in 48% inhibition of the liver HMGCR activity. However, treatment with a mixture of 5 mg of alpha-T with 10 mg of T3 resulted in lesser inhibition (13%) of the liver HMGCR activity as compared to that obtained with 10 mg of T3. The above results indicate that the alpha-T is hypercholesterolemic in the hamster and its effect on liver HMGCR is dose-dependent. T3 exhibited inhibitory effect on liver HMGCR and alpha-T attenuated the inhibitory effect of T3 on liver HMGCR.
Monoclonal antibody treatment of mixed cryoglobulinemia resistant to interferon α with an anti-CD20 (2003)

A controlled study has been carried out to assess the efficacy of rituximab, a chimeric antibody that binds to the B-cell surface antigen CD20, in 20 patients with mixed cryoglobulinemia (MC) and hepatitis C virus (HCV)-positive chronic active liver disease, resistant to interferon alpha (IFN-alpha) therapy. They received an intravenous infusion of 375 mg/m(2) rituximab once a week for 4 consecutive weeks. Infusion of rituximab had a good safety profile and no severe side effects were reported. Sixteen patients (80%) showed a complete response (CR), characterized by rapid improvement of clinical signs (disappearance of purpura and weakness arthralgia and improvement of peripheral neuropathy), and decline of cryocrit. CR was associated with a significant reduction of rheumatoid factor (RF) activity and anti-HCV antibody titers. Decline of IgG anti-HCV titers in the cryoprecipitates was usually associated with a favorable response (r = 0.81; P <.005). No differences in the dynamics of B-cell depletion and recovery were found between responders and nonresponders. Molecular monitoring of the B-cell response revealed disappearance/deletion of peripheral clones in the responders and great stability in the nonresponders. Rituximab had a deep impact on hepatitis C viremia; HCV RNA increased approximately twice the baseline levels in the responders, whereas it remained much the same in the nonresponders. Twelve (75%) of 16 responders remained in remission throughout the follow-up. The results indicate that rituximab has clinical and biologic activity in patients with HCV(+) MC. However, in view of the increased viremia in the responders, additional modes of application and combination of rituximab with other agents need to be investigated.
Anisotropic Ambient Volume Shading (2015)

We present a novel method to compute anisotropic shading for direct volume rendering to improve the perception of the orientation and shape of surface-like structures. We determine the scale-aware anisotropy of a shading point by analyzing its ambient region. We sample adjacent points with similar scalar values to perform a principal component analysis by computing the eigenvectors and eigenvalues of the covariance matrix. In particular, we estimate the tangent directions, which serve as the tangent frame for anisotropic bidirectional reflectance distribution functions. Moreover, we exploit the ratio of the eigenvalues to measure the magnitude of the anisotropy at each shading point. Altogether, this allows us to model a data-driven, smooth transition from isotropic to strongly anisotropic volume shading. In this way, the shape of volumetric features can be enhanced significantly by aligning specular highlights along the principal direction of anisotropy. Our algorithm is independent of the transfer function, which allows us to compute all shading parameters once and store them with the data set. We integrated our method in a GPU-based volume renderer, which offers interactive control of the transfer function, light source positions, and viewpoint. Our results demonstrate the benefit of anisotropic shading for visualization to achieve data-driven local illumination for improved perception compared to isotropic shading.
Reduced Fatty Acid Synthesis and Desaturation Due to Exogenous trans10, cis12-CLA in Cows Fed Oleic or Linoleic Oil (2003)

To determine effects of an elevated supply of cis9,trans11-18:2 (9/11CLA) or trans10,cis12-18:2 (10/12CLA) on de novo synthesis and desaturation of long-chain fatty acids, four Holstein cows fed high-oleic sunflower (OLE) or high-linoleic safflower oil (LIN) at 2.5% of DM were infused (0.625 g/h) with 9/11CLA or 10/12CLA for 48 h via the abomasum. Treatments were assigned in a 2 x 2 factorial design. The assigned diets were fed for 11 d before each 48-h infusion period. Milk samples were obtained at 12 and 0 h before infusion and at 12-h intervals from 0 to 96 h. Concentrations of trans11-18:1 and 18:2n-6 in arterial plasma phospholipid, triglyceride, and FFA fractions were greater due to feeding LIN compared with OLE. Infused 9/11CLA and 10/12CLA were incorporated into plasma triglycerides and FFA primarily. Exogenous 10/12CLA also was found in plasma phospholipids. Milk yield and DMI were not affected by treatments. Percentages and yields of protein, lactose, and SNF in milk also were not affected by treatments. Milk fat percentage and yield, however, decreased 25% from 0 to 96 h in response to infusion of 10/12CLA compared with 9/11CLA. Yields of trans11-18:1, 9/11CLA and 18:2n-6 in milk fat before infusion were higher when LIN was fed compared with OLE. Infusion of 9/11CLA, regardless of diet, increased 9/11CLA in milk fat by 44%. Although 10/12CLA was not detectable in milk fat before infusion, it averaged 6 mg/g of total fatty acids and 2 g/d after 48 h. At 48 h, recovery in milk of infused 9/11CLA was 16% compared with 8% for 10/12CLA. Yields of saturated 6:0 to 16:0, cis9-18:1, 9/11CLA, and 20:4n-6 were reduced by 10/12CLA infusion. Due to a 40% increase in the concentration of 18:0 by 48 h of 10/12CLA infusion, however, yield of 18:0 was not affected. Ratios of cis9-18:1/18:0, 9/11CLA/trans11-18:1, and 20:4n-6/18:2n-6 in milk fat decreased in response to infusion of 10/12CLA, regardless of diet. At peak concentration of 10/12CLA, reductions in cis9-18:1 and saturated 4:0-16:0 yields accounted for 36% and 53% of the decrease in total fatty acid yield. Results indicated 10/12CLA alters lipid metabolism in the bovine mammary gland by simultaneously reducing de novo synthesis and desaturation. Furthermore, milk triglyceride synthesis may have a stringent requirement for endogenously synthesized oleic acid.
Lens-Fed Microwave and Millimetre-Wave Receivers with Integral Antennas (1990)

A family of microwave receivers is described with antenna and semiconductor components integrated on a common substrate, in a space small enough for packing into arrays. The antenna pattern is suitable for feeding via a dielectric lens, and a balanced mixer and I.F. amplifier are integrated on the antennas. Such receivers have been built to operate around 10 and 35 GHz, and show conversions loss similar to more conventional designs.
R2CNN: Rotational Region CNN for Orientation Robust Scene Text Detection (2017)

In this paper, we propose a novel method called Rotational Region CNN (R2CNN) for detecting arbitrary-oriented texts in natural scene images. The framework is based on Faster R-CNN [1] architecture. First, we use the Region Proposal Network (RPN) to generate axis-aligned bounding boxes that enclose the texts with different orientations. Second, for each axis-aligned text box proposed by RPN, we extract its pooled features with different pooled sizes and the concatenated features are used to simultaneously predict the text/non-text score, axis-aligned box and inclined minimum area box. At last, we use an inclined non-maximum suppression to get the detection results. Our approach achieves competitive results on text detection benchmarks: ICDAR 2015 and ICDAR 2013.
Using thresholding techniques for object detection in infrared images (2014)

Image processing techniques play an important role in military applications. Image binarization could be understood as a process of pixel values segmentation of grayscale image into two value groups, zero as a background and 1 as a foreground. In simple humorapplication of object detection we assume that contrast distribution of foreground is uniformed and without background noise or that variation in contrast does not exist. However, in complex cases previous conditions are inappropriate as variation in contrast exists and it does include background noise, etc. This paper deals with object detection in infrared images for military application using an image binarization step. Military targets are detected in different conditions such as winter condition, summer condition, at night etc. This paper focuses on combination of two methods of image binarization. One is the global binarization method proposed by Otsu and the other one is the local adaptive threshold technique. The global binarization method is usually faster than the local adaptive method and the global method will give good results for specific weather conditions such as object detection in winter condition. In these cases, acquired images have uniform contrast distribution of foreground and background and little variation in illumination. We are looking for an effective method for object detection in infrared images in challenging conditions such as summer conditions or in an urban environment, where there is a shortage of objects of interest. In these cases, we employed local mean techniques and local variance techniques. The experiment results are presented so that we can better choose which method should be employed or what combination of these previous techniques to employ. In order to minimise computational time of local thresholding technique, we employed a combination of two previous techniques. The algorithm was tested in a Matlab environment and the tested pictures were acquired by RayCam C.A. 1884 and thermoIMAGER 160 cameras.
PCR-Based Method Using Propidium Monoazide To Distinguish Viable from Nonviable <i>Bacillus subtilis</i> Spores (2009)

This paper describes a molecular-based method which is able to discriminate between viable and inactivated Bacillus subtilis spores by utilizing the DNA-intercalating dye propidium monoazide. The approach should be valuable in our attempt to employ molecular methods to streamline the evaluation of process validation using bacterial endospores.
Identification of the <i>Drosophila melanogaster</i> homologue of the mammalian signal transducer protein, Vav (2000)

Mammalian Vav signal transducer protein couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. We have isolated and characterized the DroVav gene, the homologue of hVav in Drosophila melanogaster. DroVav encodes a protein (793 residues) whose similarity with hVav is 47% and with hVav2 and hVav3 is 45%. DroVav preserves the unique, complex structure of hVav proteins, including the 'calponin homology', dbl homology, pleckstrin homology; SH2 and SH3 domains in addition to regions that are acidic rich, proline rich and cysteine rich. DroVav is located on the X chromosome in polytene interval 18A5;18B and is expressed in all stages of development and in all tissues. In mammalian cells, DroVav is tyrosine-phosphorylated in response to epidermal growth factor receptor (EGFR) induction; in vitro, the DroVav SH2 region is associated with tyrosine-phosphorylated EGFR. Thus, DroVav probably plays a pivotal role as a signal transducer protein during fruit fly development.
The Story of O <sub>2</sub> (2005)

Gaseous oxygen is essential to advanced life, but Earth came with no guarantees that oxygen would abound. Researchers are piecing together life's complex involvement in oxygen's halting 3-billion-year rise
Two directional chain synthesis. The enantioselective preparation of syn-skipped polyol chains from meso precursors (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo directional chain synthesis. The enantioselective preparation of syn-skipped polyol chains from meso precursorsStuart L. Schreiber, Mark T. Goulet, and Gayle SchulteCite this: J. Am. Chem. Soc. 1987, 109, 15, 4718–4720Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://doi.org/10.1021/ja00249a044RIGHTS & PERMISSIONSArticle Views691Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (407 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Introduction to Adhesive Bonding : (2014)

接着技術の現状と，接着の信頼性に関して，考え方，指針，設計基準を示した。高信頼性接着を達成するためには，まず，接着剤の内部で破壊する凝集破壊率を40％以上にすることと，接着特性の変動係数を0.10以下にすることである。耐久性は与えられるものではなく，作り出すものである。接着の欠点はほかの接合方法でカバーするなどの工夫も信頼性向上に効果的である。
Progress in determining the structure of fragment D from human fibrinogen (1996)

C-171 accessible faces and the three four-stranded !3-sheets. One therefore might characterize tllis fold as an inside-out ex!~ bmTell. TI1e present structure reflects the open confmmation of tl1e enzyme. vVe assume that lmge confcJimational changes upon catalysis are mediated mainly tl1rough two residues, a lysin and an mginine, which me located in the cleft between tl1e two domains. These residues assure tl1e open confmmation of the native enzyme by the repulsive force between the positive chmges of two anlino groups. The binding of one of tl1e two substrates probably results in neutralizing the repulsion between the two domains tl1ereby allowing the movement of a catalytically active cystein towmd tl1e cleft.
Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase (1996)

The 1,226-amino-acid sequence of the interferon-inducible double-stranded RNA-specific adenosine deaminase (dsRAD) contains three copies (RI, RII, and RIII) of the highly conserved subdomain R motif commonly found in double-stranded RNA-binding proteins. We have examined the effects of equivalent site-directed mutations in each of the three R-motif copies of dsRAD on RNA-binding activity and adenosine deaminase enzyme activity. Mutations of the R motifs were analyzed alone as single mutants and in combination with each other. The results suggest that the RIII copy is the most important of the three R motifs for dsRAD activity and that the RII copy is the least important. The RIII mutant lacked detectable enzymatic activity and displayed greatly diminished RNA-binding activity. Site-directed mutations within the highly conserved CHAE sequence of the postulated C-terminal deaminase catalytic domain destroyed enzymatic activity but did not affect RNA-binding activity. These results indicate that the three copies of the RNA-binding R subdomain are likely functionally distinct from each other and also from the catalytic domain of dsRAD.