gebhart/patrepeval huggingface dataset:
Proteolysis of Tissue Factor Pathway Inhibitor (TFPI) by Plasmin: Effect on TFPI Activity (1998)

An important regulator of the initiation of blood coagulation is the plasma glycoprotein, tissue factor pathway inhibitor (TFPI). TFPI inhibits factor Xa and factor VIIa/tissue factor complex, thereby dampens the proteolytic cascade of the tissue factor pathway. Plasma clot lysis is primarily mediated by the fibrinolytic enzyme, plasmin, which is generated through limited proteolysis of plasminogen by endogenous or exogenously administered plasminogen activators. In this study, the interaction of plasmin with recombinant E. coli-derived TFPI (rTFPI) was examined. Plasmin was found to cause a time and concentration dependent proteolysis of rTFPI, resulting in the decrease of anti-factor Xa (measured by chromogenic substrate assay) and anticoagulant (measured by tissue factor-induced clotting assay) activities. Amino-terminal sequencing of the proteolytic fragments revealed that plasmin cleaved rTFPI at K86-T87, R107-G108, R199-A200, K249-G250, and K256-R257. Western blot analysis showed that proteolysis of exogenously added rTFPI also occurred in plasma supplemented with urokinase, and this is accompanied by decrease of anticoagulant activity. These changes were abolished by addition of aprotinin, an inhibitor of plasmin. These data indicate that TFPI is susceptible to proteolysis when plasma fibrinolytic system is activated. The results taken together suggest that plasmin degradation of TFPI may contribute to rethrombosis after thrombolysis, and may contribute to the variability of the efficacy of TFPI in various thrombolysis/reocclusion studies reported previously.
Full Compositional Flexibility in the Preparation of Mesoporous MFI Zeolites by Desilication (2011)

ISSN:1932-7455
The survival of thyroid cells: in vivo irradiation and in situ repair. (1980)

The survival of rat thyroid cells irradiated in vivo and removed immediately for transplantation survival assay was compared with results obtained previously for thyroid cells irradiated in vitro and with the survival of thyroid cells irradiated and left in situ for 24 hr before transplantation survival assay. The Do for thyroid cells irradiated in vivo and removed immediately for assay is 195 rad; N is 4 and Dq is 270 rad. These parameters are not significantly different from those obtained when thyroid cells are irradiated in vitro. When these parameters are compared to those of thyroid cells irradiated and left in situ for 24 hr, the latter have a greater N and Dq, but there is no significant difference in Do. These data provide further evidence for a form of repair of potentially lethal damage which is dependent on the tissue environment (in situ repair, ISR) as previously described for ir
Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport (2016)

A postnatal role of fibroblast growth factor receptor-1 (FGFR1) in the kidney is suggested by its binding to α-Klotho to form an obligate receptor for the hormone fibroblast growth factor-23 (FGF-23). FGFR1 is expressed in both the proximal and distal renal tubular segments, but its tubular specific functions are unclear. In this study, we crossed Fgfr1flox/flox mice with either gamma-glutamyltransferase-Cre (γGT-Cre) or kidney specific-Cre (Ksp-Cre) mice to selectively create proximal tubule (PT) and distal tubule (DT) Fgfr1 conditional knockout mice (designated Fgfr1PT-cKO and Fgfr1DT-cKO, respectively). Fgfr1PT-cKO mice exhibited an increase in sodium-dependent phosphate co-transporter expression, hyperphosphatemia, and refractoriness to the phosphaturic actions of FGF-23, consistent with a direct role of FGFR1 in mediating the proximal tubular phosphate responses to FGF-23. In contrast, Fgfr1DT-cKO mice unexpectedly developed hypercalciuria, secondary elevations of parathyroid hormone (PTH), hypophosphatemia and enhanced urinary phosphate excretion. Fgfr1PT-cKO mice also developed a curly tail/spina bifida-like skeletal phenotype, whereas Fgfr1DT-cKO mice developed renal tubular micro-calcifications and reductions in cortical bone thickness. Thus, FGFR1 has dual functions to directly regulate proximal and distal tubule phosphate and calcium reabsorption, indicating a physiological role of FGFR1 signaling in both phosphate and calcium homeostasis.
MUGI i Sydafrika (2014)

En stor skillnad ar forstas att har cyklar inte studenterna, har kor de bil. I narheten av universitetet finns foljaktligen enormt stora parkeringsplatser. Dessutom finns fantastiskt stora ytor och faciliteter i direkt anslutning till institutionen Sportwetenskap/Sport Science, flera stora rugbyplaner, fotbollsplaner, landhockeyplaner, alla mycket valskotta grona grasplaner samt minst atta basket(eller korgbolls-)planer och ca tio tennisbanor. Pa berget bakom institutionen klattrar motionsslingor i vacker natur runt en liten fiskesjo. Dessutom finns stora simbassanger bade utomoch inomhus. Har finns stora idrottsoch gymnastikhallar, gym och mindre traningsrum. Ja, som idrottslararutbildare vid Malmo hogskola ar det inte svart att hapna, baxna och forbluffas!
Nano-Crystallization of High-Entropy Amorphous NbTiAlSiWxNy Films Prepared by Magnetron Sputtering (2016)

High-entropy amorphous NbTiAlSiWxNy films (x = 0 or 1, i.e., NbTiAlSiNy and NbTiAlSiWNy) were prepared by magnetron sputtering method in the atmosphere of a mixture of N2 + Ar (N2 + Ar = 24 standard cubic centimeter per minute (sccm)), where N2 = 0, 4, and 8 sccm). All the as-deposited films present amorphous structures, which remain stable at 700 °C for over 24 h. After heat treatment at 1000 °C the films began to crystalize, and while the NbTiAlSiNy films (N2 = 4, 8 sccm) exhibit a face-centered cubic (FCC) structure, the NbTiAlSiW metallic films show a body-centered cubic (BCC) structure and then transit into a FCC structure composed of nanoscaled particles with increasing nitrogen flow rate. The hardness and modulus of the as-deposited NbTiAlSiNy films reach maximum values of 20.5 GPa and 206.8 GPa, respectively. For the as-deposited NbTiAlSiWNy films, both modulus and hardness increased to maximum values of 13.6 GPa and 154.4 GPa, respectively, and then decrease as the N2 flow rate is increased. Both films could be potential candidates for protective coatings at high temperature.
Solubility of Phenylacetic Acid, <i>p</i>-Hydroxyphenylacetic Acid, <i>p</i>-Aminophenylacetic Acid, <i>p</i>-Hydroxybenzoic Acid, and Ibuprofen in Pure Solvents (2002)

The solubility of phenyl acetic acid, p-hydroxyphenylacetic acid, p-aminophenylacetic acid, p-hydroxybenzoic acid, and ibuprofen in water and in a range of organic solvents of relevance to industrial processing is reported. The solvents used are water, methanol, ethanol, 2-propanol, acetone, 4-methyl-2-pentanone, ethyl acetate, chloroform, and toluene. Solubility data are discussed from the standpoint of molecular aspects of solute−solvent interactions and by estimated solid-phase activity.
Black Wattle Tannin As Steel Corrosion Inhibitor (2012)

In order to reduce the environmental impacts caused by chemical substances harmful to the environment and human health, the black wattle tannin can be used as an environmentally friendly corrosion inhibitor in acid and near neutral media. This paper provides information on the application of black wattle tannin as an inhibitor against the corrosion of carbon steel. The inhibition was evaluated using potentiodynamic polarization (PP) and electrochemical impedance spectroscopy (EIS) at room temperature in aerated 0.1 mol L −1 Na 2 SO 4 (pH 6.0 and 2.5). The black wattle tannin when used as a corrosion inhibitor is more effective at acidic pH, its efficiency being dependent on its concentration. At the higher pH value (pH 6.0), a blue-black film (ferric tannate) with a short-term protection against corrosion was formed in aerated aqueous solution. At pH 2.5, this blue-black film was not observed.
An Antenna Co-Design Dual Band RF Energy Harvester (2013)

RF energy is widely available in urban areas and thus presents a promising ambient energy harvesting source. In this paper, a CMOS harvester circuit is modeled and analyzed in detail at low environmental power levels. Based on the circuit analysis, a design procedure is given for a narrowband energy harvester. The antenna and harvester co-design methodology is discussed to improve RF to DC energy conversion efficiency. We demonstrate that it is difficult to harvest RF energy over a wide frequency band if the ambient RF energy sources are weak, owing to the voltage requirements. Since most ambient RF energy lies in a few narrow bands, a dual/multi-band energy harvester architecture should be able to harvest much of the available RF energy. A dual-band CMOS energy harvester is designed and fabricated using an IBM 0.13 μm process. The simulated and measured results demonstrate a dual-band energy harvester that obtains over 9% efficiency for two different bands (around 900 MHz and around 1900 MHz) at an input power as low as -19.3 dBm. The DC output voltage of this harvester is over 1 V, which can be used to recharge the battery to form an inexhaustibly powered communication system.
Three-Dimensional Surface Imaging in Plastic Surgery (2015)

Three-dimensional surface imaging has gained clinical acceptance in plastic and reconstructive surgery. In contrast to computed tomography/magnetic resonance imaging, three-dimensional surface imaging relies on triangulation in stereophotography to measure surface x, y, and z coordinates. This study reviews the past, present, and future directions of three-dimensional topographic imaging in plastic surgery. Historically, three-dimensional imaging technology was first used in a clinical setting in 1944 to diagnose orthodontologic conditions. Karlan established its use in the field of plastic surgery in 1979, analyzing contours and documenting facial asymmetries. Present use of three-dimensional surface imaging has focused on standardizing patient topographic measurements to enhance preoperative planning and to improve postoperative outcomes. Various measurements (e.g., volume, surface area, vector distance, curvature) have been applied to breast, body, and facial topography to augment patient analysis. Despite the rapid progression of the clinical applications of three-dimensional imaging, current use of this technology is focused on the surgeon's perspective and secondarily the patient's perspective. Advancements in patient simulation may improve patient-physician communication, education, and satisfaction. However, a communal database of three-dimensional surface images integrated with emerging three-dimensional printing and portable information technology will validate measurements and strengthen preoperative planning and postoperative outcomes. Three-dimensional surface imaging is a useful adjunct to plastic and reconstructive surgery practices and standardizes measurements to create objectivity in a subjective field. Key improvements in three-dimensional imaging technology may significantly enhance the quality of plastic and reconstructive surgery in the near future.
[In situ FTIR spectrocopic studies of CO and CN- adsorbed on electrode of nanometer thin film of palladium in alkaline solutions]. (2000)

The adsorption and coadsorption of CO and CN- on electrode of nanometer thin film of palladium (nm-Pd/GC) was studied by using in situ FTIR spectroscopy. The results demonstrated that the nm-Pd/GC electrode exhibited abnormal infrared effects (AIREs) in alkaline solutions as in acid solutions. The characters of AIREs, i.e., the inversion of the direction of IR band, the augmentation of FWHM and the significant enhancement of IR absorption by adsorbed species were observed in all cases of adsorption and coadsorption of CO and CN-. It has been illustrated that strong interaction is existed between adsorbed CO and CN- on nm-Pd/GC surface. The study has contributed towards understanding the surface processes of chemisorption as well as to reveal the origin of nanometer size-effects of thin film materials.
Miniaturized Wideband Metasurface Antennas Using Cross-Layer Capacitive Loading (2021)

One kind of cross-layer capacitive-loaded metasurface (MS) structure is proposed and applied to realize miniaturized wideband MS antennas. The proposed MS structure is constructed by loading a thin substrate with several stacked patches above conventional MS structure, where the cross-layer stacked patches are located upon the gaps between the original MS units. Therefore, additional capacitances can be introduced accordingly, and then help decrease the resonance frequency effectively. Based on above strategies, when the resonance frequency remains unchanged, the proposed MS structure with smaller aperture size can provide equivalent capacitive reactance and inductive reactance with conventional MS structure. In this way, the miniaturization can be realized while the wideband feature is still remained. By optimizing the loading structure, symmetrical and asymmetrical MS structures are designed accordingly and different-level miniaturizations are realized, where the element sizes can be respectively miniaturized to 0.067 <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">λ</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> × 0.067 <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">λ</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> and 0.059 <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">λ</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> × 0.059 <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">λ</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> . For demonstration, onw asymmetrical capacitive-loaded MS structure is used to realize a compact wideband MS antenna, where large impedance bandwidth (∼44.4%) and compact size (∼0.41 <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">λ</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> × 0.41 <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">λ</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) are obtained. This design method may provide a feasible solution to realize compact wideband MS antennas for broadband wireless communication systems.
Modulation of Host PGE<sub>2</sub> Secretion as a Determinant of Periodontal Disease Expression (1993)

An increasing body of evidence supports the concept that host-produced PGE2 mediates much of the tissue destruction that occurs in periodontal disease. PGE2 levels within the crevicular fluid can serve as a static assessment of ongoing disease activity; i.e., rate of attachment loss and bone resorption. New insights into the mechanisms that regulate PGE2 synthesis provide an altered paradigm of periodontal disease which places the emphasis on host response, rather than the bacterial etiology, as the principal determinant of disease expression. We described a PGE2 host response model as a hypothetical framework to discuss new, possible explanations for host susceptibility to periodontal disease.
Fecal Calprotectin Excretion in Preterm Infants during the Neonatal Period (2010)

During the first weeks of life, the high f-calprotectin values observed in preterm infants could be linked to the gut bacterial establishment.
Energy Efficient Reconfigurable Threshold Logic Circuit with Spintronic Devices (2016)

A Threshold Logic Gate (TLG) performs weighted summation of multiple binary inputs and compares the summation with a threshold. Different logic functions can be implemented by reconfiguring the weights and threshold of the same TLG circuit. This paper introduces a novel design of reconfigurable Spintronic Threshold Logic Gate (STLG), which employs spintronic weight devices to perform current-mode weighted summation of binary inputs, whereas, the low voltage fast switching spintronic threshold device carries out the threshold operation in an energy efficient manner. The proposed STLG operates at a small terminal voltage of 50 mV, resulting in ultra-low energy consumption. A bottom-up cross-layer simulation framework is developed to synthesize and map large scale digital logic functions to the proposed STLG circuits. The simulation results of ISCAS-85 benchmarks show that the proposed STLG based reconfigurable logic hardware can achieve two orders lower Energy-Delay Product (EDP) compared with state-of-the-art CMOS Field Programmable Gate Arrays (FPGA), and smaller EDP compared to large scale Memristive Threshold Logic (MTL) based FPGA. Moreover, the ultra-low programming energy of spintronic weight device also leads to three orders lower reconfiguration energy of STLG compared to MTL design.
Serological diagnostic kit of SARS-CoV-2 antibodies using CHO-expressed full-length SARS-CoV-2 S1 proteins (2020)

WHO has declared COVID-19 a pandemic with more than 300,000 confirmed cases and more than 14,000 deaths. There is urgent need for accurate and rapid diagnostic kits. Here we report the development and validation of a COVID-19/SARS-CoV-2 S1 serology ELISA kit for the detection of total anti-virus antibody (IgG+IgM) titers in sera from either the general population or patients suspected to be infected. For indirect ELISA, CHO-expressed recombinant full length SARS-CoV-2-S1 protein with 6* His tag was used as the coating antigen to capture the SARS-CoV-2-S1 antibodies specifically. The specificity of the ELISA kit was determined to be 97.5%, as examined against total 412 normal human sera including 257 samples collected prior to the outbreak and 155 collected during the outbreak. The sensitivity of the ELISA kit was determined to be 97.5% by testing against 69 samples from hospitalized and/or recovered COVID-19 patients. The overall accuracy rate reached 97.3%. Most importantly, in one case study, the ELISA test kit was able to identify an infected person who had previously been quarantined for 14 days after coming into contact with a confirmed COVID-19 patient, and discharged after testing negative twice by nucleic acid test. With the assays developed here, we can screen millions of medical staffs in the hospitals and people in residential complex, schools, public transportations, and business parks in the epidemic centers of the outbreaks to fish out the “innocent viral spreaders”, and help to stop the further spreading of the virus.
Novel <i>KIR3DL1</i> Alleles and Their Expression Levels on NK Cells: Convergent Evolution of KIR3DL1 Phenotype Variation? (2008)

KIR3DL1 shows extensive polymorphism, and its variation has functional significance in terms of cell-surface expression levels and inhibitory capacity. We characterized nine KIR3DL1 alleles (*022, *028, *029, *033, *035, *051, *052, *053, and *054), four of which were identified for the first time in this study, and compared them to known alleles in phylogenetic analysis. Blood was available from eight individuals with these alleles, and cell-surface expression on NK cells could be determined for six of them using the KIR3DL1-specific Ab DX9. Four of the alleles were expressed at clearly detectable levels, and two others showed exceptionally low levels of expression. Site-directed mutagenesis demonstrated that single amino acid changes can result in either diminished or enhanced DX9 staining compared with the respective related KIR3DL1 allotypes. These results raise the possibility that KIR3DL1 evolution maintains variation in KIR3DL1 cell-surface expression levels, potentially due to the effect of such variation on functional capacity.
Post-transcriptional regulation of proinflammatory proteins (2004)

Post-transcriptional mechanisms play a critical role in regulating the expression of numerous proteins that promote inflammatory arthritis. The mRNAs encoding a subset of these proteins possess adenine/uridine-rich elements (AREs) in their 3'-untranslated regions that profoundly influence the rate at which mRNA is degraded and translated into protein. Tristetraprolin (TTP) and T cell intracellular antigen-1 (TIA-1) are ARE-binding proteins that dampen the expression of this class of proteins by promoting mRNA degradation and protein translation, respectively. We have discovered that TIA-1 and TTP function as arthritis-suppressor genes: TIA-1-/- mice develop mild arthritis, TTP-/- mice develop severe arthritis, and TIA-1-/-TTP-/- mice develop very severe arthritis. Paradoxically, lipopolysaccharide (LPS)-activated macrophages derived from TIA-1-/-TTP-/- macrophages produce less tumor necrosis factor alpha (TNF-alpha) than TIA-1-/- or TTP-/- macrophages. The bone marrows of these mice exhibit increased cellularity, reflecting the presence of mature neutrophils that secrete TNF-alpha in response to LPS stimulation. We hypothesize that TIA-1-/-TTP-/- neutrophils are a source of arthritigenic TNF-alpha, which promotes severe erosive arthritis in these mice.
Concentration of Human Hematopoietic Stem Cells in Bone Marrow Transplantation: Results of a Multicenter Study Using Baxter CS 3000 plus Cell Separator (1993)

Preliminary BM processing to produce an enriched MNC fraction from large BM volumes improves subsequent pharmacological and/or immunological “ex vivo” treatment and cryopreservation. We detail on a multicenter study (6 Transplant Centers) performed to establish an effective and reliable protocol using a CS 3000 continuous flow separator on a large series of BM processed for autologous (96) and allogeneic (12) transplantation. The reduction in volume was 78.6+7.2% while 28.9+12.4% of the original nucleated cells were found in the final product. A mean of 84.3+13.2% of the starting MNC was yielded in a fraction containing over 81% MNC. Cloning efficiency indicated than the final graft was highly enriched in progenitor cells committed to the granulocyte/macrophage pathway (> 100%) as assessed in vitro (CFU-GM). Removal of RBC and PLT was 98.3+1.1 and 37.7+14.6%, respectively. The mean dose of MNC and CFU-GM was 0.6+0.37 x 10 8 and 0.96+1 x 10 8 recipient weight. The entire process was accomplished in 87.5+20 min. We concluded that this automated device is a simple and reproducible method for BM processing suitable as first step for further “ex vivo” automated negative and/or positive cell selections.
<title>Printing images from the Web</title> (2000)

Images have become ubiquitous, virtually every personal computer and every Internet WEB site contains at least some number of images. Professional as well as amateur artists display their work on the net and large image collections exist, spanning all aspects of art, hobby and daily life. The images vary widely in content, but more importantly, they also vary widely in general image quality attributes. Some of the quality variation is caused by the actual image creation or internet posting process, whereas some other quality variations are caused by the lack of defining image data description, like color-space definition. This paper describes problems and possible solutions associated with the printing of images from unknown sources.