gebhart/patrepeval huggingface dataset:
Effect of Carbohydrate Intake During Warming-up on the Regulation of Blood Glucose During Exercise* (1989)

It has been shown that the intake of carbohydrate (CHO)-containing beverages under resting conditions may lead to a rebound hypoglycemia and decreased performance when exercise is performed thereafter. The aim of the present investigation was to study the effect of CHO beverage consumption with different CHO sources and different concentrations, during warming-up under practice-like circumstances, on the regulation of blood glucose during exercise. Eighteen highly trained cyclists consumed a standardized breakfast at 8:00 AM and performed a warming-up procedure at 10:00 AM for 20 min. Warming-up was followed by a 7-min break after which the subjects cycled for 45 min at a heart rate of 150. During warming-up a CHO-containing beverage (either sucrose, fructose, maltodextrin, or glucose) or a placebo was consumed in random order. The test was performed twice, with 300 ml and 600 ml intake, to study a possible dose-response effect. The results of the study showed that warming-up and final exercise lead to an increase of the catecholamines and a decrease of insulin. During the 7-min break this response was reversed. Glucose and maltodextrin induced the same insulin response. Increasing volume and higher CHO concentrations induced a longer increase in blood glucose level compared with the placebo intake. The results showed that intake of CHO-containing beverages during warming-up followed by a small break does not lead to rebound hypoglycemia, independent of the amount of CHO ingested, but instead increases blood glucose.
Mutual information-based CT-MR brain image registration using generalized partial volume joint histogram estimation (2003)

Mutual information (MI)-based image registration has been found to be quite effective in many medical imaging applications. To determine the MI between two images, the joint histogram of the two images is required. In the literature, linear interpolation and partial volume interpolation (PVI) are often used while estimating the joint histogram for registration purposes. It has been shown that joint histogram estimation through these two interpolation methods may introduce artifacts in the MI registration function that hamper the optimization process and influence the registration accuracy. In this paper, we present a new joint histogram estimation scheme called generalized partial volume estimation (GPVE). It turns out that the PVI method is a special case of the GPVE procedure. We have implemented our algorithm on the clinically obtained brain computed tomography and magnetic resonance image data furnished by Vanderbilt University. Our experimental results show that, by properly choosing the kernel functions, the GPVE algorithm significantly reduces the interpolation-induced artifacts and, in cases that the artifacts clearly affect registration accuracy, the registration accuracy is improved.
Statistical Motion Information Extraction and Representation for Semantic Video Analysis (2009)

In this paper, an approach to semantic video analysis that is based on the statistical processing and representation of the motion signal is presented. Overall, the examined video is temporally segmented into shots and for every resulting shot appropriate motion features are extracted; using these, hidden Markov models (HMMs) are employed for performing the association of each shot with one of the semantic classes that are of interest. The novel contributions of this paper lie in the areas of motion information processing and representation. Regarding the motion information processing, the kurtosis of the optical flow motion estimates is calculated for identifying which motion values originate from true motion rather than measurement noise. Additionally, unlike the majority of the approaches of the relevant literature that are mainly limited to global- or camera-level motion representations, a new representation for providing local-level motion information to HMMs is also presented. It focuses only on the pixels where true motion is observed. For the selected pixels, energy distribution-related information, as well as a complementary set of features that highlight particular spatial attributes of the motion signal, are extracted. Experimental results, as well as comparative evaluation, from the application of the proposed approach in the domains of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Tennis</i> , <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">News</i> and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Volleyball</i> broadcast video, and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Human Action</i> video demonstrate the efficiency of the proposed method.
Novelty Detection using Deep Normative Modeling for IMU-Based Abnormal Movement Monitoring in Parkinson’s Disease and Autism Spectrum Disorders (2018)

Detecting and monitoring of abnormal movement behaviors in patients with Parkinson's Disease (PD) and individuals with Autism Spectrum Disorders (ASD) are beneficial for adjusting care and medical treatment in order to improve the patient's quality of life. Supervised methods commonly used in the literature need annotation of data, which is a time-consuming and costly process. In this paper, we propose deep normative modeling as a probabilistic novelty detection method, in which we model the distribution of normal human movements recorded by wearable sensors and try to detect abnormal movements in patients with PD and ASD in a novelty detection framework. In the proposed deep normative model, a movement disorder behavior is treated as an extreme of the normal range or, equivalently, as a deviation from the normal movements. Our experiments on three benchmark datasets indicate the effectiveness of the proposed method, which outperforms one-class SVM and the reconstruction-based novelty detection approaches. Our contribution opens the door toward modeling normal human movements during daily activities using wearable sensors and eventually real-time abnormal movement detection in neuro-developmental and neuro-degenerative disorders.
Targeting Transient Receptor Potential Channels in Cardiometabolic Diseases and Myocardial Ischemia Reperfusion Injury (2016)

On the basis of these discoveries, the therapeutic potential of targeting novel TRP channels can be proposed for the treatment of cardiometabolic diseases and I/R injury.
Log compaction and garbage collection-What could they bring to each other? (2002)

This paper describes the compaction techniques and problems and compares them to those of garbage collection. By studying how certain garbage collection problems are solved in the context of log compaction, it tries to suggest new paths of research for garbage collection in the domains of distribution, parallelisation and fault-tolerance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells. (2001)

Endothelin-1 (ET-1) is present at high concentrations in ovarian cancer ascites and is overexpressed in primary and metastatic ovarian carcinoma. In these cells, ET-1 acts as an autocrine mitogenic and angiogenic factor selectively through the ET(A) receptor (ET(A)R). We investigated at mRNA and protein levels whether ET-1 could affect the expression and activation of metastasis-related proteinases and whether this process was associated with ovarian tumor cell invasion. ELISA, gelatin zymography, Western blot, and reverse transcription-PCR analyses demonstrated that in two ovarian carcinoma cell lines (HEY and OVCA 433), the expression of matrix metalloproteinase (MMP) -2, -9, -3, -7, and -13 was up-regulated and activated by ET-1. Moreover we observed that ET-1 was able to enhance the secretion and activation of membrane-type metalloproteinase-1, a critical mediator of invasiveness. The secretion of tissue inhibitor of metalloproteinase-1 and -2 was decreased by ET-1, which increased the net MMP/tissue inhibitor of metalloproteinase balance and the gelatinolytic capacity. In addition, ET-1 induced overexpression of urokinase-type plasminogen activator, its receptor, and plasminogen activator inhibitor type-1 and -2. Finally, we demonstrated that, in HEY and OVCA 433 cells, ET-1 dose-dependently increased migration and MMP-dependent invasion through Matrigel. BQ123, an antagonist of the ET(A)R, inhibited the ET-1-induced tumor protease activity and subsequent increase in cell migration and invasion. These findings demonstrate that ET-1 promotes ovarian carcinoma cell invasion, acting through the ET(A)R by up-regulating secretion and activation of multiple tumor proteinases. Therefore, ET-1 may represent a key component of more aggressive ligand-induced invasiveness of ovarian carcinoma.
Reduction in drop size of ophthalmic topical drop preparations and the impact of treatment (2011)

In this work we devised a method to create smaller eye drops of the glaucoma medication timolol maleate by altering the dropper tip design and changing the physical properties of the formulation. Most ocular diseases are treated with topical application of eye drops. After instillation of an eye drop, typically, less than 5% of the applied drug penetrates the cornea and reaches the intraocular tissues; the major fraction of the instilled drug is absorbed and enters the systemic circulation. Ophthalmic solutions are available in multidose or single-dose glass/plastic dropper bottles that deliver drops with a volume that ranges from 25 μL to 70 μL (average 40 μL). Because of the low capacity of the precorneal area, the optimal drop volume is about 20 μL; with larger volumes there is the risk of adverse systemic effects due to absorption of the drug via the nasal mucosa. Thus, both from the biopharmaceutical and economic point of view, drops of only 5-15 mL volume should be instilled into the eye. In this present work we devised a method to reduce the size of the drop by inserting a glass capillary tube into the dropper tip and by changing the physical properties of the formulation (by altering the concentration of Tween 80™, i.e., 0.05% and 0.1% of Tween 80™). We measured the drop sizes of the different timolol eye drop formulations available in the market and estimated the yearly cost of the medications. Our timolol maleate formulation with 0.1% concentration of Tween 80™ delivered through the dropper tip with the inserted glass capillary was shown to be better than the other formulations available in the market in terms of ability to deliver smaller drops, meaning that each bottle would last longer and that the yearly cost of treatment would be lower.
A −236.3dB FoM sub-sampling low-jitter supply-robust ring-oscillator PLL for clocking applications with feed-forward noise-cancellation (2017)

A 2-2.8GHz 65nm CMOS ring oscillator PLL occupies an active area of 0.022mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , consumes 5.86mW and achieves a 633fs RMS jitter at 2.36 GHz and an FOM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">jitter</sub> of -236.3dB. It implements a low-overhead feed-forward phase and supply-noise cancellation scheme by leveraging the noise extraction inherently done by the sub-sampling phase detector. Cancellation reduces the jitter by 1.4x, the phase noise by 10.2dB to -123.5dBc/Hz at a 300KHz offset, and the ring oscillator supply sensitivity by 19.5dB for a 1mV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p-p</sub> 100KHz supply noise tone.
ChemInform Abstract: TOTAL SYNTHESIS OF THE L‐HEXOSES (1983)

Abstract Die Arbeit beschreibt die Synthese sämtlicher möglichen L‐Hexosen aus nicht chiralen Ausgangsverbindungen.
Enhanced retinal vasculature imaging with a rapidly configurable aperture (2018)

In adaptive optics scanning laser ophthalmoscope (AOSLO) systems, capturing multiply scattered light can increase the contrast of the retinal microvasculature structure, cone inner segments, and retinal ganglion cells. Current systems generally use either a split detector or offset aperture approach to collect this light. We tested the ability of a spatial light modulator (SLM) as a rapidly configurable aperture to use more complex shapes to enhance the contrast of retinal structure. Particularly, we varied the orientation of a split detector aperture and explored the use of a more complex shape, the half annulus, to enhance the contrast of the retinal vasculature. We used the new approach to investigate the influence of scattering distance and orientation on vascular imaging.
Pathways of Protein Secretion in Eukaryotes (1985)

Protein secretion from cells can take several forms. Secretion is constitutive if proteins are secreted as fast as they are synthesized. In regulated secretion newly synthesized proteins destined for secretion are stored at high concentration in secretory vesicles until the cell receives an appropriate stimulus. When both constitutive and regulated protein secretion can take place in the same cell a mechanism must exist for sorting the correct secretory protein into the correct secretory vesicle. The secretory vesicle must then be delivered to the appropriate region of plasma membrane. Transfection of DNA encoding foreign secretory proteins into regulated secretory cells has provided insight into the specificity of sorting into secretory vesicles.
Indoor Navigation Validation Framework for Visually Impaired Users (2017)

In this paper, we introduce the first validation framework of an indoor navigation system for blind and visually impaired (BVI) users, which is a significant step toward the development of cost effective indoor way-finding solutions for BVI users. The BVI users require detailed landmark-based navigation instructions that will help them arrive at the chosen destination independently. These users will interact with the navigation instructions on a smartphone using an accessible user interface. The validation framework includes the following three main components: 1) virtual reality-based simulation that simulates a BVI user traversing and interacting with the physical environment, developed using Unity game engine; 2) generation of action codes that emulate the avatar movement in the virtual environment, developed using a natural language processing parser of the navigation instructions; and 3) accessible user interface, which enables the user to access the navigation instructions, developed using Sikuli script library. We introduce a case study that illustrates the use of the validation tool using PERCEPT system. It is our strong belief that the validation framework we provide in this paper will encourage other developers to invent indoor navigation systems for BVI users. In addition, we would like to mention that this tool is the first step of validating an indoor navigation system and should be followed by trials with human subjects.
Evolutionary history of Coleoptera revealed by extensive sampling of genes and species (2018)

Beetles (Coleoptera) are the most diverse and species-rich group of insects, and a robust, time-calibrated phylogeny is fundamental to understanding macroevolutionary processes that underlie their diversity. Here we infer the phylogeny and divergence times of all major lineages of Coleoptera by analyzing 95 protein-coding genes in 373 beetle species, including ~67% of the currently recognized families. The subordinal relationships are strongly supported as Polyphaga (Adephaga (Archostemata, Myxophaga)). The series and superfamilies of Polyphaga are mostly monophyletic. The species-poor Nosodendridae is robustly recovered in a novel position sister to Staphyliniformia, Bostrichiformia, and Cucujiformia. Our divergence time analyses suggest that the crown group of extant beetles occurred ~297 million years ago (Mya) and that ~64% of families originated in the Cretaceous. Most of the herbivorous families experienced a significant increase in diversification rate during the Cretaceous, thus suggesting that the rise of angiosperms in the Cretaceous may have been an 'evolutionary impetus' driving the hyperdiversity of herbivorous beetles.
<p>Cholesterol-rich lipid-mediated nanoparticles boost of transfection efficiency, utilized for gene editing by CRISPR-Cas9</p> (2019)

<b>Purpose:</b> Gene therapy has become a promising remedy to treat disease by modifying the person's genes. The therapeutic potential of related tools such as CRISPR-Cas9 depends on the efficiency of delivery to the targeted cells. Numerous transfection reagents have been designed and lots of efforts have been devoted to develop carriers for this purpose. Therefore, the aim of the present study was to develop novel cholesterol-rich lipid-based nanoparticles to enhance transfection efficiency and serum stability. <b>Materials and methods:</b> We constructed two-, three- and four-component cationic liposomes (CLs) to evaluate the combined effect of cholesterol domain and DOPE (dioleoyl phosphatidylethanolamine), a fusogenic lipid, and the PEG (polyethylene glycol) moiety location inside or outside of the cholesterol domain on transfection efficiency and other properties of the particle. Lipoplex formation and pDNA (plasmid DNA) entrapment were assessed by gel retardation assay at different N/P ratios (3, 5, 7). Physicochemical characteristics, cytotoxicity, serum stability and endosomal escape capability of the lipoplexes were studied and transfection potential was measured by firefly luciferase assay. Next, HEK293 cell line stably expressing GFP was utilized to demonstrate the editing of a reporter through Cas9 and sgRNA plasmids delivery by the selected CL formula, which showed the highest transfection efficiency. <b>Results:</b> Among the designed CLs, the four-component formula [DOTAP (1,2-dioleoyl-3-trimethylammoniumpropane)/DOPE/cholesterol/Chol-PEG (cholesterol-polyethylene glycol)] showed the highest rate of transfection at N/P 3. Finally, transfection of Cas9/sgRNA by this formulation at N/P 3 resulted in 39% gene-editing efficiency to knockout GFP reporter. The results also show that this CL with no cytotoxicity effect can totally protect the plasmids from enzymatic degradation in serum. <b>Conclusion:</b> The novel PEGylated cholesterol domain lipoplex providing serum stability, higher transfection efficiency and endosomal release can be used for in vivo Cas9/sgRNA delivery and other future gene-therapy applications.
Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI (1998)

We have isolated a novel cDNA encoding a peptide with 86% sequence homology to hSNF2L protein, a previously isolated human homologue of Drosophila ISWI. This gene, designated SMARCA5, contained an open reading frame of 3,156 nucleotides encoding a 1,052 amino-acid peptide (hSNF2H). As this product also revealed a significant (73%) identity in amino acid sequence to ISWI, a key component of chromatin-remodeling factors in Drosophila, hSNF2H may be another human homologue of this protein and, as such, could be involved in chromatin remodeling in humans. An ATPase domain characteristic of the SWI2/SNF2 family of proteins was highly conserved in ISWI, hSNF2L, and hSNF2H. Northern-blot analysis demonstrated ubiquitous expression of 5.1-kb and 4.1-kb transcripts of the hSNF2H gene. This gene was mapped by FISH to chromosome bands 4q31.1-->q31.2.
Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study (2019)

CM patients have a stronger connectivity in the pain matrix than do EM patients. Functional alteration of the pain network might play a role in migraine chronification.
Day 1 multiple organ dysfunction syndrome is associated with poor functional outcome and mortality in the pediatric intensive care unit (2009)

Using the largest clinical dataset to date and consensus definitions for organ failure, we found that children with MODS present on day 1 of intensive care unit admission have worse functional outcomes, higher mortality, and longer PICU length of stay than children who do not have MODS on day 1. Infants are disproportionally affected by MODS.
Market Segmentation and 1992: Toward a Theory of Trade in Financial Services (1991)

The effect of the unification of the European banking market on the efficiency of the allocation of capital across Europe depends on the economic forces behind banking structure. Such forces are not well understood. The paper discusses a conceptual framework for analyzing financial services (especially bank loans and deposits), in which a key distinction is between services offered across borders and those services where location of the intermediary matters. Empirical evidence from Italy is examined that suggests that banking markets are geographically fragmented, possibly because of natural, as opposed to regulatory, barriers to capital mobility. In the light of this conceptual framework and the empirical results, the likely effect of European integration on real capital mobility and efficiency of banking markets is discussed.
Ping-pong beam training with hybrid digital-analog antenna arrays (2017)

In this article we propose an iterative training scheme that approximates optimal beamforming between two transceivers equipped with hybrid digital-analog antenna arrays. Inspired by methods proposed for digital arrays that exploit algebraic power iterations, the proposed training procedure is based on a series of alternate (ping-pong) transmissions between the two devices over a reciprocal channel. During the transmissions, the devices update their digital beamformers by conjugation and normalization operations on the received digital signal, while the analog beamformers are progressively updated by a simple “beam split and drop” strategy that tracks the directions from which signals with largest magnitude are being received. The resulting scheme has minimal computational complexity and converges with only a handful of iterations. As shown in the numerical assessment, the method approximates the top singular mode of the channel, hence performing very closely to optimal beamforming.
Visual software development using an object-relationship model (1999)

Article Free Access Share on Visual software development using an object-relationship model Authors: Kenneth Messa Department of Mathematics and Computer Science, Loyola University, New Orleans, La. Department of Mathematics and Computer Science, Loyola University, New Orleans, La.View Profile , Bogdan Czejdo Department of Mathematics and Computer Science, Loyola University, New Orleans, La. Department of Mathematics and Computer Science, Loyola University, New Orleans, La.View Profile Authors Info & Claims ACM-SE 37: Proceedings of the 37th annual Southeast regional conference (CD-ROM)April 1999 Pages 12–eshttps://doi.org/10.1145/306363.306380Published:01 April 1999Publication History 2citation249DownloadsMetricsTotal Citations2Total Downloads249Last 12 Months6Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF