gebhart/patrepeval huggingface dataset:
Transcriptional regulation of IGF-I expression in skeletal muscle (2003)

The present study investigated the role of transcription in the regulation of insulin-like growth factor (IGF)-I expression in skeletal muscle. RT-PCR was used to determine endogenous expression of IGF-I pre-mRNA and mRNA in control (Con) and functionally overloaded (FO) rat plantaris. The transcriptional activities of five different-length IGF-I promoter fragments controlling transcription of a firefly luciferase (FLuc) reporter gene were tested in vitro by transfection of myoblasts or in vivo during FO by direct gene transfer into the plantaris. Increased endogenous IGF-I gene transcription during 7 days of plantaris FO was evidenced by an approximately 140-160% increase (P < 0.0001) in IGF-I pre-mRNA (a transcriptional marker). IGF-I mRNA expression also increased by approximately 90% (P < 0.0001), and it was correlated (R = 0.93; P < 0.0001) with the pre-mRNA increases. The three longest IGF-I exon 1 promoters induced reporter gene expression in proliferating C2C12 and L6E9 myoblasts. In differentiated L6E9 myotubes, promoter activity increased approximately two- to threefold over myoblasts. Overexpression of calcineurin and MyoD increased the activity of the -852/+192 promoter in C2C12 myotubes by approximately 5- and approximately 18-fold, respectively. However, FO did not induce these exogenous promoter fragments. Nevertheless, the present findings are consistent with the hypothesis that the IGF-I gene is transcriptionally regulated during muscle hypertrophy in vivo as evidenced by the induction of the endogenous IGF-I pre-mRNA during plantaris FO. The exon 1 promoter region of the IGF-I gene is sufficient to direct inducible expression in vitro; however, an in vivo response to FO may require elements outside the -852/+346 region of the exon 1 IGF-I promoter or features inherent to the endogenous IGF-I gene.
Highly Ordered Mesoporous CuCo<sub>2</sub>O<sub>4</sub> Nanowires, a Promising Solution for High-Performance Supercapacitors (2015)

The search for faster, safer, and more efficient energy storage systems continues to inspire researchers to develop new energy storage materials with ultrahigh performance. Mesoporous nanostructures are interesting for supercapacitors because of their high surface area, controlled porosity, and large number of active sites, which promise the utilization of the full capacitance of active materials. Herein, highly ordered mesoporous CuCo2O4 nanowires have been synthesized by nanocasting from a silica SBA-15 template. These nanowires exhibit superior pseudocapacitance of 1210 F g–1 in the initial cycles. Electroactivation of the electrode in the subsequent 250 cycles causes a significant increase in capacitance to 3080 F g–1. An asymmetric supercapacitor composed of mesoporous CuCo2O4 nanowires for the positive electrode and activated carbon for the negative electrode demonstrates an ultrahigh energy density of 42.8 Wh kg–1 with a power density of 15 kW kg–1 plus excellent cycle life. We also show that two asymmetric devices in series can efficiently power 5 mm diameter blue, green, and red LED indicators for 60 min. This work could lead to a new generation of hybrid supercapacitors to bridge the energy gap between chemical batteries and double layer supercapacitors.
Crystal structures of the X‐domains of a Group‐1 and a Group‐3 coronavirus reveal that ADP‐ribose‐binding may not be a conserved property (2008)

The polyproteins of coronaviruses are cleaved by viral proteases into at least 15 nonstructural proteins (Nsps). Consisting of five domains, Nsp3 is the largest of these (180-210 kDa). Among these domains, the so-called X-domain is believed to act as ADP-ribose-1''-phosphate phosphatase or to bind poly(ADP-ribose). However, here we show that the X-domain of Infectious Bronchitis Virus (strain Beaudette), a Group-3 coronavirus, fails to bind ADP-ribose. This is explained on the basis of the crystal structure of the protein, determined at two different pH values. For comparison, we also describe the crystal structure of the homologous X-domain from Human Coronavirus 229E, a Group-1 coronavirus, which does bind ADP-ribose.
Construction of polycyclic systems by cyclocarbonylation. Part 3. A novel palladium- or platinum-catalyzed cyclocarbonylation reaction of cinnamyl compounds for synthesis of 1-naphthol derivatives (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConstruction of polycyclic systems by cyclocarbonylation. Part 3. A novel palladium- or platinum-catalyzed cyclocarbonylation reaction of cinnamyl compounds for synthesis of 1-naphthol derivativesHiroyuki Matsuzaka, Yoshitaka Hiroe, Masakazu Iwasaki, Youichi Ishii, Yukio Koyasu, and Masanobu HidaiCite this: J. Org. Chem. 1988, 53, 16, 3832–3838Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/jo00251a031https://doi.org/10.1021/jo00251a031research-articleACS PublicationsRequest reuse permissionsArticle Views370Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Levels of 4‐aminobiphenyl‐induced somatic H‐<i>ras</i> mutation in mouse liver DNA correlate with potential for liver tumor development (2005)

The utility of liver H-ras codon 61 CAA to AAA mutant fraction as a biomarker of liver tumor development was investigated using neonatal male mice treated with 4-aminobiphenyl (4-ABP). Treatment with 0.1, 0.3, or 1.0 mumol 4-ABP produced dose-dependent increases in liver DNA adducts in B6C3F(1) and C57BL/6N mice. Eight months after treatment with 0.3 mumol 4-ABP or the DMSO vehicle, H-ras codon 61 CAA to AAA mutant fraction was measured in liver DNA samples (n = 12) by allele-specific competitive blocker-polymerase chain reaction (ACB-PCR). A significant increase in average mutant fraction was found in DNA of 4-ABP-treated mice, with an increase from 1.3 x 10(-5) (control) to 44.9 x 10(-5) (treated) in B6C3F(1) mice and from 1.4 x 10(-5) to 7.0 x 10(-5) in C57BL/6N mice. Compared with C57BL/6N mutant fractions, B6C3F(1) mutant fractions were more variable and included some particularly high mutant fractions, consistent with the more rapid development of liver foci expected in B6C3F(1) mouse liver. Twelve months after treatment, liver tumors developed in 79.2% of 4-ABP-treated and 22.2% of control B6C3F(1) mice; thus measurement of H-ras mutant fraction correlated with subsequent tumor development. This study demonstrates that ACB-PCR can directly measure background levels of somatic oncogene mutation and detect a carcinogen-induced increase in such mutation.
The tactical aircraft moving map capability (TAMMAC) (2003)

The US Navy is currently developing the Tactical Aircraft Moving Map Capability (TAMMAC) program to acquire a common digital map to be used in a variety of Navy and Marine Corps aircraft. Digital map requirements for both fixed and rotary wing platforms were combined with the results from human factors studies to arrive at the desired capabilities that shaped the requirements for the TAMMAC program. The resultant system offers a significant improvement in aircrew situational awareness, particularly during nap of the Earth (NOE) flight and other high crew workload flight regimes. The baseline capabilities of the system will, in themselves, allow users to tailor the digital map operation to suit the needs of their particular missions. Considerable thought has already been given to identifying and shaping the growth capabilities described for the TAMMAC system. However, a methodical study, including flight crew interaction and human factors activities, should be undertaken to guide the platforms in deciding how to manage the considerable growth capabilities offered by the system.
Accrue Discovery Regulation for Autonomous Robotic Control of Marine Cybernetics and Automation (2016)

This article expresses the devise of the "Accrue Discovery" regulation for the robotic control of an inundated marine cybernetics and automation. A considerable confederation of momentous relevance can be controlled by permitting such a robot to pursue a plummet or analogous poignant object. The robot exercises a matching set of intellect expertise, chiefly supported by computer vision, allowing it to pilot in flurry and petty marine surroundings. Accrue Discovery (AD) regulation depicted in this article, tolerates the robot to trail and follow a specified object at the bottom of the sea water. The automated marine control is wrapped up of two discrete elements namely; a hunter and a feedback controller. The robotic AD regulation by means of trifling adoptions can be tattered while the robot might stride and accrue on the earth surface furthermore.
Analysis of observer performance in known-location tasks for tomographic image reconstruction (2005)

We consider the task of detecting a statistically varying signal of known location on a statistically varying background in a reconstructed tomographic image. We analyze the performance of linear observer models in this task. We show that, if one chooses a suitable reconstruction method, a broad family of linear observers can exactly achieve the optimal detection performance attainable with any combination of a linear observer and linear reconstructor. This conclusion encompasses several well-known observer models from the literature, including models with a frequency-selective channel mechanism and certain types of internal noise. Interestingly, the "optimal" reconstruction methods are unregularized and in some cases quite unconventional. These results suggest that, for the purposes of designing regularized reconstruction methods that optimize lesion detectability, known-location tasks are of limited use.
Experience With a New Detergent Lid Scrub in the Management of Chronic Blepharitis (1988)

<h3>To the Editor.</h3> —Chronic blepharitis is one of the most common ocular disorders in humans.<sup>1</sup>It often can be a very annoying and difficult condition to treat. Whereas some patients complain only of red and itchy eyes, blepharitis can also make the adaptation to contact lenses extremely difficult, aggravate or slow the treatment of keratitis sicca, endanger intraocular surgery, or lead to corneal complications, such as toxic epithelial keratitis, catarrhal ulceration, or phlyctenulosis.<sup>2</sup>There is no definitive and precise treatment for this condition. However, it is well accepted that lid scrubs may improve the condition for long periods. Baby shampoo has been the usual medication for lid scrubs in chronic blepharitis. However, a number of patients complain of irritation when using this shampoo if it spills onto the conjunctival surface. Recently, we tried a new detergent called I-Scrub (Spectra Pharmaceutical Services Inc, Hanover, Mass), which we have found
[Expression, purification and enzymatic characterization of adenylate kinase of Thermus thermophilus HB27 in Escherichia coli]. (2010)

The gene coding for adenylate kinase of Thermus thermophilus HB27 has been successfully cloned and expressed in Escherichia coil, which provides the basis for potential use of the highly thermostable recombinant HB27 adenylate kinase.
CNN based Indoor Localization using RSS Time-Series (2018)

Indoor localization of mobile nodes is receiving great interest due to the recent advances in mobile devices and the increasing number of location-based services. Fingerprinting based on Wifi received signal strength (RSS) is widely used for indoor localization due to its simplicity and low hardware requirements. However, its positioning accuracy is significantly affected by random fluctuations of RSS values caused by fading and multi-path phenomena. This paper presents a convolutional neural network (CNN) based approach for indoor localization using RSS time-series from wireless local area network (WLAN) access points. Applying CNN on a time-series of RSS readings is expected to reduce the noise and randomness present in separate RSS values and hence improve the localization accuracy. The proposed model is implemented and evaluated on a multi-building and multi-floor dataset, UJIIndoorLoc dataset. The proposed approach provides 100% accuracy for building prediction, 100% accuracy for floor prediction and the mean error in coordinates estimation is 2.77 m.
The Mythology of Threshold Variations as a Function of Electrode Surface Area (1991)

It has been established that the chronic thresholds of cardiac pacing leads vary as a function of the (spherical) electrode's radius or (geometric) surface area and the thickness of fibrotic encapsulation. Where the radius of the electrode is equal to the thickness of the fibrous capsule (about 0.7 to 1 mm for polished surfaces), threshold should be at a minimum. Where the radius of the electrode is larger or smaller than the thickness of the fibrous capsule, then thresholds should increase since the electric field strength required to stimulate decreases as the square of the distance between the electrode's surface and stimulatable tissue. In addition, it has become (incorrectly) accepted that small electrodes do not sense well. About 8-mm electrodes, therefore, became the "standard" surface area, providing the best tradeoffs between pacing and sensing. Analysis of 18 years of canine data in our laboratory, however, suggest that these relationships may be overemphasized for the surface areas of clinical interest. In fact, new small porous and steroid-eluting electrodes do not have high thresholds, are efficient, and their sensing is excellent.
Temporally Consistent Road Surface Profile Estimation Using Stereo Vision (2018)

Road surface profile (RSP) estimation is an important task to find the imperfections of a road surface, thereby improving ride quality. The RSP estimation has been recently studied using stereo vision owing to its affordable price. However, the existing methods provide noisy and temporally unstable results for real-world driving scenes because of noisy range measurements, noisy pitch angle estimates between the camera and the road surface, and interference from obstacles. This paper proposes a novel method for temporally consistent and robust RSP estimation to overcome these problems. The proposed method consists of three steps: free space estimation, digital elevation map (DEM) estimation, and RSP estimation. We first estimate a drivable area, i.e., free space. For robust and fast free space estimation, we propose an optimization-based non-parametric road surface modeling method and an integral disparity histogram-based free space estimation method. Then, the DEM of the road surface is estimated using range measurements on the free space to avoid obstacle interference. The DEM is temporally updated every frame using the moving average filter and the DEM reference grid update scheme. Owing to these strategies, the proposed method reduces the elevation estimation noise and the pitch angle error, and therefore provides the temporally consistent RSP. We demonstrate the superiority of the proposed method experimentally using stereo image sequences captured in real-world driving scenes.
Silicon micromachined waveguide components at 0.75 to 1.1 THz (2014)

Silicon micromachined waveguide components operating in the WM-250 (WR-1) waveguide band (0.75 to 1.1 THz) are measured. Through lines are used to characterize the waveguide loss with and without an oxide etch to reduce the surface roughness. A sidewall roughness of 100nm is achieved, enabling a waveguide loss of 0.2dB/mm. A 1THz band-pass filter is also measured to characterize the precision of fabrication process. A 1.8% shift in frequency is observed and can be accounted for by the 0.5deg etch angle and 2um expansion of the features by the oxide etch. The measured filter has a 13% 3dB bandwidth and 2.5dB insertion loss through the passband.
A comparison of blade tip timing data analysis methods (2001)

The experimental determination of the vibration characteristics of rotating engine blades is very important for fatigue failure considerations. One of the most promising techniques for measuring the frequency of blade vibrations is blade tip timing. In this paper, three vibration analysis methods were specifically formulated and applied to the tip timing problem for the first time, using data obtained from a simple mathematical blade tip timing simulation. The results from the methods were compared statistically in order to determine which of the techniques is more suitable. One of the methods, the global autoregressive instrumental variables approach, produced satisfactory results at realistic noise levels. However, all of the techniques produced biased results under certain circumstances.
Transformation of short-term spectral envelope of speech signal using multivariate polynomial modeling (2011)

Speaker transformation uses a mapping between the signal parameters derived from a set of phrases spoken by two speakers to modify the speech signal of one speaker to make it perceptually similar to that of the other speaker. In spectral warping and interpolation technique, the transformation function can be estimated using lesser data, but it needs a different transformation function for each acoustic class. Earlier reported investigations have used class dependent multivariate linear regression or univariate cubic interpolation. In this paper, a technique for modifying spectral characteristics, using a multivariate polynomial modeling for source-target mapping of the spectral parameters, is presented. Harmonic plus Noise Model (HNM) has been used for analysis-synthesis because of ease of the time and frequency scaling.
Comparison of Peripheral and Portal (Via the Umbilical Vein) Routes of Insulin Infusion in IDDM Patients (1992)

Twelve subjects with insulin-dependent diabetes mellitus were treated using continuous subcutaneous insulin infusion (CSII) and intraportal insulin infusion (IPII) via the umbilical vein for 4 mo. Glucose control improved in both CSII and IPII groups, but a decrease in glucose and HbAIc was more rapid and more significant in the IPII group than in CSII, even though insulin requirement was lower during IPII than CSII (40 +/- 2 vs. 50 +/- 2 U/day, P less than 0.05). The insulin plasma fasting levels were different (88 +/- 10.7 in the IPII group vs. 263 +/- 23 pM in CSII, P less than 0.001). High plasma levels of lactate, pyruvate, alanine, cortisol, and growth hormone were decreased in both groups, with their full normalization only in the IPII group. Glucagon concentrations were low in both groups at the beginning of the study (30.0 +/- 4.1 in the CSII group and 32.3 +/- 1.8 ng/L in IPII); they were equalized to control values in the IPII group and were low in the CSII group at the study's end (46.0 +/- 3.7 in IPII vs. 31.7 +/- 3.1 ng/L in CSII, P less than 0.05. We conclude that intraportal administration of insulin via the umbilical vein at rates of 0.01-0.05 U.kg-1.hr-1 reduces plasma levels of glucose, three carbon precursors, cortisol, and growth hormone by a direct action on the liver, and the hepatic action of peripherally administered insulin is manifested only when the infusion rate is increased to 0.1-0.3 U.kg-1.hr-1.(ABSTRACT TRUNCATED AT 250 WORDS)
Persistence+undoability=transactions (1992)

Persistence means objects live potentially forever. Undoability means that any change to a program's store can potentially be undone. In their design and implementation of support for single-threaded nested transactions in Standard ML of New Jersey (SML/NJ), the authors provide persistence and undoability as orthogonal features and combine them in a simple and elegant manner. They provide support for persistence through an SML interface that lets users manipulate a set of persistent roots and provides a save function that causes all data reachable from the persistent roots to be moved into the persistent heap. They provide support for undoability through an SML interface that exports two functions: checkpoint, which checkpoints the current store, and restore, which undoes all changes made to the previously checkpointed store. Finally, they succinctly define a higher-order function transact completely in terms of the interfaces for persistence and undoability.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells (2016)

These data are consistent with the concept that ox-LDL play a role in the pathogenesis of AMD by NLRP3 inflammasome activation. Suppression of NLRP3 inflammasome activation could attenuate RPE degeneration and AMD progression.
Comparing metabolomes: the chemical consequences of hybridization in plants (2005)

Hybridization may lead to unique phytochemical expression in plant individuals. Hybrids may express novel combinations or extreme concentrations of secondary metabolites or, in some cases, produce metabolites novel to both parental species. Here we test whether there is evidence for extreme metabolite expression or novelty in F1 hybrids between Senecio aquaticus and Senecio jacobaea. Hybridization is thought to occur frequently within Senecio, and hybridization might facilitate secondary metabolite diversification within this genus. Parental species express different quantities of several classes of compounds known to be involved in antiherbivore defence, including pyrrolizidine alkaloids, chlorogenic acid, flavonoids and benzoquinoids. Hybrids demonstrate differential expression of some metabolites, producing lower concentrations of amino acids, and perhaps flavonoids, than either parental species. Despite evidence for quantitative hybrid novelty in this system, NMR profiling did not detect any novel compounds among the plant groups studied. Metabolomic profiling is a useful technique for identifying qualitative changes in major metabolites according to plant species and/or genotype, but is less useful for identifying small differences between plant groups, or differences in compounds expressed in low concentrations.