gebhart/patrepeval huggingface dataset:
Ferrocene-containing polyamides and polyureas (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFerrocene-containing polyamides and polyureasKenneth Gonsalves, Lin Zhan-Ru, and Marvin D. RauschCite this: J. Am. Chem. Soc. 1984, 106, 13, 3862–3863Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/ja00325a027https://doi.org/10.1021/ja00325a027research-articleACS PublicationsRequest reuse permissionsArticle Views825Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of silver nitrate and polyethylene glycol on white spruce (<i>Picea glauca</i>) somatic embryo development: enhancing cotyledonary embryo formation and endogenous ABA content (1995)

In vitro cultures and endogenous abscisic acid (ABA) analyses with gas chromatography‐selected ion monitoring‐mass spectrometry (GC‐SIM‐MS) were used to study the effects of AgNO 3 and polyethylene glycol (PEG) on white spruce ( Picea glauca ) somatic embryo maturation and endogenous ABA contents, Normally, in the absence of ABA, white spruce somatic embryos cannot mature. However, AgNO 3 and PEG stimulated somatic embryo maturation by increasing the number of cotyledonary embryos. A combination of 100 μ M AgNO 3 and 40 g l −1 PEG was the treatment that was most effective in enhancing cotyledonary embryo formation without exogenous ABA. Either AgNO 3 or PEG was able to increase endogenous ABA levels of the embryogenic culture but a combination of AgNO 3 and PEG was the most effective treatment. Stimulation of cotyledonary embryo formation by AgNO 3 occurred only at low ABA levels, while PEG promoted embryo formation at all exogenous ABA concentrations. Germination tests indicated that AgNO 3 had no negative effects on embryo germination and conversion while the PEG‐treated embryos failed to germinate.
Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes (2008)

Inhibition of dipeptidyl peptidase-4 (DPP-4) prevents the inactivation of glucagon-like peptide-1 (GLP-1). This increases circulating levels of active GLP-1, stimulates insulin secretion and inhibits glucagon secretion, resulting in lowering of glucose levels and improvement of glycemic control in patients with type 2 diabetes. Several DPP-4 inhibitors are emerging for therapeutic use. Most experience exists for sitagliptin, vildagliptin, saxagliptin and alogliptin. They all improve metabolic control in type 2 diabetes in monotherapy and in combination therapy with metformin, sulfonylurea and thiazolidinediones. Vildagliptin and alogliptin have also been shown to improve glycemic control when added to insulin therapy, and sitagliptin improves glycemic control in triple therapy with metformin plus thiazolidinedione. DPP-4 inhibition also shows a favorable safety profile, high tolerability, only a minimal risk of hypoglycemia, and body-weight neutrality. The main clinical indication for DPP-4 inhibitors will be in the early stage of type 2 diabetes, in combination with metformin or other treatments in subjects with inadequate glycemic control on these treatments alone. The durability and long-term safety of DPP-4 inhibition, as well as clinical positioning in relation to GLP-1 mimetics, remain now to be established.
Antibodies to Epitopes of Herpes Simplex Virus Type 1 Glycoprotein B (gB) in Human Sera: Analysis of Functional gB Epitopes Defined by Inhibition of Murine Monoclonal Antibodies (1993)

The epitopes on herpes simplex virus (HSV) glycoprotein B (gB) recognized by sera of 23 patients with well-characterized HSV infection were studied. Twelve epitope-specific monoclonal antibodies with neutralization (NT) or antibody-dependent cellular cytotoxicity (ADCC) activities were used in competitive ELISA binding inhibition studies. The sera were additionally analyzed for homologous viral type NT, ADCC activity, and gB-reactive antibody by ELISA. Seroconversion was observed in each assay during convalescence. Relative type specificity for sera from HSV-1-infected but not from HSV-2-infected individuals was demonstrated in the ADCC assay. Sera from HSV-infected patients contained antibodies recognizing 9 of 12 epitopes, representing 5 of the 6 characterized antigenic domains of gB tested. Two of the epitopes were blocked in a type-specific fashion. The incidence of epitopic recognition increased gradually with time and was delayed compared with the detection of functional ADCC or NT activity and overall antibody recognition of gB in the ELISA.
1.5 W diffraction-limited-beam operation from resonant-optical-waveguide (ROW) array (1991)

Strong intermodal discrimination is demonstrated for antiguided diode-laser arrays designed to operate in a resonant condition for the inphase mode. These resonant-optical-waveguide (ROW) arrays radiate in a diffraction-limited beam up to 1.5 W under pulsed operation and 360 mW under CW operation, without need for active phase control.
Human Rights, Asian Values, and the Clash of Civilizations (1998)

During the Cold War a simple, bipolar model of world politics was dominant. After the Cold War, some politicians and scholars believed that the West had won, and that the Western conception of liberal democracy would become a model for the world. This view was, however, almost immediately challenged by the idea of ”Asian values” proposed by certain East Asian political leaders and intellectuals. To the debate about Eastern, Western, and universal values, Samuel Huntington contributed his dramatic thesis of ”the clash of civitlizations.” This thesis caught the attention of many scholars because it evoked both Western fears of challenges from non-Western resentment at Western cultural hegemony. The thesis also seemed consonant with the ”Asian values” challenge. This view of the Huntington thesis is, however, mistaken on several counts. First, the thesis rests on a highly implausible account of human nature and history. Second, the argument is based on a misreading of post-Cold War global politics. Third, the Huntington thesis, far from reinforcing the ”Asian values” argument, is inconsistent with it. Fourth, the ”Asian values” argument is itselfbased on a misreading of contemporary politics. Fifth, the Huntington thesis and the ”Asian values” argument are both dangerous because they could become self-fulfilling prophecies of violent conflict. Sixth, Huntington's policy conclusions about human rights and international order inconsistent with the thesis of the clash of civilizations. This article concludes, therefore, that both Huntington's thesis and ”Asian values” argument should be rejected as empirically misleading and politically dangerous. In their place, we should reaffirm the internationalist program of human rights promotion, which Huntington and the ”Asian values” advocates have called into question, mistakenly, and with potential harmful consequences for the future of international relations.
A highly integrated dual band sige BiCMOS power amplifier that simplifies dual-band WLAN and MIMO front-end circuit designs (2010)

A highly integrated SiGe BiCMOS power amplifier for dual-band WLAN applications is presented. The PA has 2 and 3 stages of amplification for the 'b/g' and 'a' band, respectively, and integrates the input/output matching network, out-of-band rejection filter, power detector, and bias control. The die area is 1.7 × 1.6 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The b/g amplifier achieves 28 dB gain with 19.5 dBm output power at 3% EVM and 185mA and harmonics of <;-45dBm/Mhz. The a-band amplifier achieves 30 dB gain with 3% EVM at 19.0 dBm output with 220mA of current and harmonics <; -50 dBm/MHz. The reported PA linearity, out-of-band rejection, and integration level exceeds previously reported WLAN dual-band SiGe PA designs.
Neuromorphic Silicon Neuron Circuits (2011)

Hardware implementations of spiking neurons can be extremely useful for a large variety of applications, ranging from high-speed modeling of large-scale neural systems to real-time behaving systems, to bidirectional brain-machine interfaces. The specific circuit solutions used to implement silicon neurons depend on the application requirements. In this paper we describe the most common building blocks and techniques used to implement these circuits, and present an overview of a wide range of neuromorphic silicon neurons, which implement different computational models, ranging from biophysically realistic and conductance-based Hodgkin-Huxley models to bi-dimensional generalized adaptive integrate and fire models. We compare the different design methodologies used for each silicon neuron design described, and demonstrate their features with experimental results, measured from a wide range of fabricated VLSI chips.
Archetypal <i>NOTCH3</i> mutations frequent in public exome: implications for CADASIL (2016)

The frequency of EGFr cysteine altering <i>NOTCH3</i> mutations is 100-fold higher than expected based on estimates of CADASIL prevalence. This challenges the current CADASIL disease paradigm, and suggests that certain mutations may more frequently cause a much milder phenotype, which may even go clinically unrecognized. Our data suggest that individuals with a mutation located in EGFr domains 1-6 are predisposed to the more severe "classical" CADASIL phenotype, whereas individuals with a mutation outside of EGFr domains 1-6 can remain paucisymptomatic well into their eighth decade.
Idiopathic omental bleeding (2012)

Omental bleeding without any evidence of trauma, aneurysms, or other pathology has been rarely described in the literature. We report a case of a 24 year-old female on aspirin/acetaminophen/caffeine for migraines who presented with abdominal pain and tachycardia. Computed tomography angiography revealed active extravasation in the right lower quadrant. During exploratory laparotomy, a small bleeding artery within the greater omentum was suture ligated, and two liters of fresh and clotted blood were evacuated. The patient recovered successfully. We review the diagnosis and management of this rare condition.
Electrical Resistivity of Selected Elements (1984)

This work compiles, reviews, and discusses the available data and information on the electrical resistivity of hafnium, molybdenum, tantalum, tungsten, and zinc and presents the recommended values resulting from critical evaluation, correlation, analysis, and synthesis of the available data and information. The recommended values presented are both uncorrected and also corrected for the thermal expansion of the material and cover the temperature range from 1 K to above the melting point into the molten state. The estimated uncertainties in most of the recommended values are about ±2% to ±10%.
Binding of [3H]forskolin to rat brain membranes. (1984)

[12-3H]Forskolin (27 Ci/mmol) has been used to study binding sites in rat brain tissue by using both centrifugation and filtration assays. The binding isotherm measured in the presence of 5 mM MgCl2 by using the centrifugation assay is described best by a two-site model: Kd1 = 15 nM, Bmax1 (maximal binding) = 270 fmol/mg of protein; Kd2 = 1.1 microM; Bmax2 = 4.2 pmol/mg of protein. Only the high-affinity binding sites are detected when the binding is determined by using a filtration assay; Kd = 26 nM, Bmax = 400 fmol/mg of protein. Analogs of forskolin that do not activate adenylate cyclase (EC 4.6.1.1) do not compete effectively for [3H]forskolin binding sites. Analogs of forskolin that are less potent than forskolin in activating adenylate cyclase are also less potent in competing for forskolin binding sites. The presence of 5 mM MgCl2 or MnCl2 was found to enhance binding. In the presence of 1 mM EDTA the amount of high-affinity binding is reduced to 110 fmol/mg of protein with no change in Kd. There is no effect of CaCl2 (20 mM) or NaCl (100 mM) on the binding. No high-affinity binding can be detected in membranes from ram sperm, which contains an adenylate cyclase that is not activated by forskolin. It is proposed that the high-affinity binding sites for forskolin are associated with the activated complex of catalytic subunit and stimulatory guanine nucleotide binding protein.
Rwandan female genital modification: Elongation of the <i>Labia minora</i> and the use of local botanical species (2008)

The elongation of the labia minora is classified as a Type IV female genital mutilation by the World Health Organization. However, the term mutilation carries with it powerful negative connotations. In Rwanda, the elongation of the labia minora and the use of botanicals to do so is meant to increase male and female pleasure. Women regard these practices as a positive force in their lives. This paper aims to assess whether Rwandan vaginal practices should indeed be considered a form of female genital mutilation and whether the botanicals used by women are detrimental to their health. Research was carried out in the northeast of Rwanda over the course of 13 months. Semi-structured interviews were conducted with thirteen informants. Two botanicals applied during stretching sessions were identified as Solanum aculeastrum Dunal and Bidens pilosa L. Both have wide medicinal use and contain demonstrated beneficial bioactive compounds. We suggest that it is therefore more appropriate to describe Rwandan vaginal practices as female genital modification rather than mutilation.
SPCp1-04: Bit Mapping and Error Insertion for FEC Based PAPR Reduction in OFDM Signals (2006)

This paper proposes a new method for peak-to-average power ratio (PAPR) reduction in orthogonal frequency division multiplexing (OFDM) systems using forward error correction (FEC). The scheme combines the intentional insertion of correctable errors into the data stream with a specialized bit mapping. The latter deviates from traditional Gray encoding of bits into modulation symbols in order to maximize the benefits of FEC-based PAPR reduction. Using the code redundancy, the proposed scheme achieves significant reduction in PAPR and satisfactory bit error rate (BER) performance at the expense of acceptable computational complexity. Specifically, the complementary cumulative distribution function (CCDF) of the coded signal shows about a 5dB improvement over the original OFDM signal. In addition, BER performance in an additive white Gaussian noise demonstrates trade-offs between reduction in PAPR and remaining error correction capability of the deployed codes.
Data Stream Management Systems for Computational Finance (2010)

Because financial applications rely on a continual stream of time-sensitive data, any data management system must be able to process complex queries on the fly. Although many organizations turn to custom solutions, data stream management systems can offer the same low-latency processing with the flexibility to handle a range of applications.
Performance of a 350 character TFT-LC display panel (1977)

The problems encountered in increasing the resolution of a 6" × 6" TFT addressed liquid crystal display from 20 lpi to 30 lpi are described, together with the solutions developed. The major problem relates to the reduced capacitance of the LC element resulting in a lack of frame period storage. Two approaches were utilized: the first consisted of a systematic effort to analyze the factors that influence off "leakage" current in the TFT. As a consequence of this a TFT with leakage current of less than one nanoampere was achieved. The alternate approach was to incorporate an extra 5 pF capacitor in each display element. A layout of the matrix circuit was developed which incorporated the capacitor under the gate bus bar, thereby avoiding a sacrifice in the active area of the display element. Both approaches were successful and good quality displays fabricated. Electrical design considerations, TFT fabrication principles and performance of the resulting 6" × 6" 30 lpi TFT-LC panel will be presented.
Hydrogel-Textile Composites (2020)

The current work examines interactions that are enabled when depositing a human-safe hydrogel onto textile substrates. These hydrogel-textile composites are water-responsive, supporting reversible actuation. To enable these interactions, we describe a fabrication process using a consumer-grade 3D printer. We show how different combinations of printed hydrogel patterns and textiles create a rich actuator design space. Finally, we show an application of this approach and discuss opportunities for future work.
Use of the HemoCue <sup>®</sup> near patient testing device to measure the concentration of haemoglobin in suction fluid at elective Caesarean section* (2008)

We have investigated the suitability of the HemoCue photometer to measure the concentration of haemoglobin in suction fluid obtained at elective caesarean section in 30 women. Laboratory analysis was used as a gold standard against which values generated by the HemoCue were compared. We used the method of Bland and Altman to analyse the data. The bias and the limits of agreement were -0.013 and -0.39 to 0.36 mg x dl(-1) respectively, indicating a good level of agreement. Mean (SD) total blood loss calculated using these data, combined with the weight of the swabs, was consistently greater than clinical estimation: 768 (496) ml versus 506 (249) ml respectively (p < 0.001). We have found that the HemoCue near patient testing device may be used to estimate blood loss accurately in the suction fluid obtained at elective Caesarean section.
Distance Computation Between Binary Code and Real Vector for Efficient Keypoint Matching (2013)

Image recognition in client server system has a problem of data traffic. However, reducing data traffic gives rise to worsening of performance. Therefore, we represent binary codes as high dimensional local features in client side, and represent real vectors in server side. As a result, we can suppress the worsening of the performance, but it problems of an increase in the computational cost of the distance computation and a different scale of norm between feature vectors. Therefore, to solve the first problem, we optimize the scale factor so as to absorb the scale difference of Euclidean norm. For second problem, we compute efficiently the Euclidean distance by decomposing the real vector into weight factors and binary basis vectors. As a result, the proposed method achieves the keypoint matching with high-speed and high-precision even if the data traffic was reduced.
A dual-feed circularly-polarized traveling-wave array antenna (2014)

A traveling-wave circularly-polarized microstrip array antenna is presented in this paper. It uses a circularly polarized dual-feed radiating element. The element is a rectangular patch with two chamfered corners. It is fed by microstrip lines, making it possible for the radiating element and feed lines to be realized and integrated in a single layer. A four-element array is designed, built and tested. Measured performance of the antenna is presented, where a good agreement between the simulated and measured results is obtained and demonstrated.
Aldo-keto reductase (AKR) superfamily: Genomics and annotation (2009)

Aldo-keto reductases (AKRs) are phase I metabolising enzymes that catalyse the reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)-dependent reduction of carbonyl groups to yield primary and secondary alcohols on a wide range of substrates, including aliphatic and aromatic aldehydes and ketones, ketoprostaglandins, ketosteroids and xenobiotics. In so doing they functionalise the carbonyl group for conjugation (phase II enzyme reactions). Although functionally diverse, AKRs form a protein superfamily based on their high sequence identity and common protein fold, the (alpha/beta) 8 -barrel structure. Well over 150 AKR enzymes, from diverse organisms, have been annotated so far and given systematic names according to a nomenclature that is based on multiple protein sequence alignment and degree of identity. Annotation of non-vertebrate AKRs at the National Center for Biotechnology Information or Vertebrate Genome Annotation (vega) database does not often include the systematic nomenclature name, so the most comprehensive overview of all annotated AKRs is found on the AKR website (http://www.med.upenn.edu/akr/). This site also hosts links to more detailed and specialised information (eg on crystal structures, gene expression and single nucleotide polymorphisms [SNPs]). The protein-based AKR nomenclature allows unambiguous identification of a given enzyme but does not reflect the wealth of genomic and transcriptomic variation that exists in the various databases. In this context, identification of putative new AKRs and their distinction from pseudogenes are challenging. This review provides a short summary of the characteristic features of AKR biochemistry and structure that have been reviewed in great detail elsewhere, and focuses mainly on nomenclature and database entries of human AKRs that so far have not been subject to systematic annotation. Recent developments in the annotation of SNP and transcript variance in AKRs are also summarised.
Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells (2016)

In humans and animals lacking functional LDL receptor (LDLR), LDL from plasma still readily traverses the endothelium. To identify the pathways of LDL uptake, a genome-wide RNAi screen was performed in endothelial cells and cross-referenced with GWAS-data sets. Here we show that the activin-like kinase 1 (ALK1) mediates LDL uptake into endothelial cells. ALK1 binds LDL with lower affinity than LDLR and saturates only at hypercholesterolemic concentrations. ALK1 mediates uptake of LDL into endothelial cells via an unusual endocytic pathway that diverts the ligand from lysosomal degradation and promotes LDL transcytosis. The endothelium-specific genetic ablation of Alk1 in Ldlr-KO animals leads to less LDL uptake into the aortic endothelium, showing its physiological role in endothelial lipoprotein metabolism. In summary, identification of pathways mediating LDLR-independent uptake of LDL may provide unique opportunities to block the initiation of LDL accumulation in the vessel wall or augment hepatic LDLR-dependent clearance of LDL.
Taming the Wild: A Unified Analysis of Hogwild!-Style Algorithms. (2015)

Stochastic gradient descent (SGD) is a ubiquitous algorithm for a variety of machine learning problems. Researchers and industry have developed several techniques to optimize SGD's runtime performance, including asynchronous execution and reduced precision. Our main result is a martingale-based analysis that enables us to capture the rich noise models that may arise from such techniques. Specifically, we use our new analysis in three ways: (1) we derive convergence rates for the convex case (Hogwild!) with relaxed assumptions on the sparsity of the problem; (2) we analyze asynchronous SGD algorithms for non-convex matrix problems including matrix completion; and (3) we design and analyze an asynchronous SGD algorithm, called Buckwild!, that uses lower-precision arithmetic. We show experimentally that our algorithms run efficiently for a variety of problems on modern hardware.