gebhart/patrepeval huggingface dataset:
Integrin-linked Kinase Controls Neurite Outgrowth in N1E-115 Neuroblastoma Cells (2001)

Mouse N1E-115 cells grown on a laminin matrix exhibit neurite outgrowth in response to serum deprivation. Treatment of cells with an antibody against beta(1) integrin inhibits neurite outgrowth. Thus, beta(1) integrin is involved in the neuritogenesis of N1E-115 cells on a laminin matrix. Integrin-linked kinase (ILK), a recently identified cytoplasmic serine/threonine protein kinase that binds to the cytoplasmic domain of beta(1) integrin, has an important role in transmembrane signal transduction via integrins. We report that ILK is expressed in N1E-115 cells, the expression levels of which are constant under both normal and differentiating conditions. A stable transfection of a kinase-deficient mutant of ILK (DN-ILK) results in inhibition of neurite outgrowth in serum-starved N1E-115 cells grown on laminin. On the other hand, a transient expression of wild type ILK stimulated neurite outgrowth. The ILK activity in the parental cells was transiently activated after seeding on the laminin matrix, whereas that in the DN-ILK-transfected cells was not. These results suggest that transient activation of ILK is required for neurite outgrowth in serum-starved N1E-115 cells on laminin. Under the same conditions, p38 mitogen-activated protein (MAP) kinase, but neither MAP kinase/extracellular signal-regulated kinase kinase (MEK) nor extracellular signal-regulated kinases (ERK), was transiently activated after N1E-115 cell attachment to laminin, but not in the DN-ILK-expressed cells. The time course of p38 MAP kinase activation was very similar to that of ILK activation. Furthermore, a p38 MAP kinase inhibitor, SB203580, significantly blocked neurite outgrowth. Thus, activation of p38 MAP kinase is involved in ILK-mediated signal transduction leading to integrin-dependent neurite outgrowth in N1E-115 cells.
The Masculinization of the Fetus during Pregnancy Due to Inhalation of Diesel Exhaust (2001)

This study was conducted to determine the impact of diesel exhaust inhalation on the fetus. Seventy-two pregnant rats and 18 nonpregnant rats were divided into three groups: a group exposed to total diesel engine exhaust containing 5.63 mg/m(3) particulate matter, 4.10 ppm nitrogen dioxide, and 8.10 ppm nitrogen oxide; a group exposed to filtered exhaust without particulate matter; and a group exposed to clean air. The exposure period was from day 7 until day 20 of pregnancy. In addition, 15 pregnant rats were treated with aromatase inhibitors or testosterone to clarify the process by which diesel exhaust exerts its toxicity. The anogenital distance was significantly longer in male and female fetuses from both exhaust-exposed groups than in those of the control. Differentiation of the testis, ovary, and thymus was delayed and disturbed. Maternal testosterone and progesterone levels, which increased due to pregnancy whether or not the rats were exposed, were significantly higher and lower, respectively, in the pregnant rats exposed to total exhaust and filtered exhaust. The serum adrenocorticotropic hormone (ACTH) level and urinary excretion of 17-hydroxycorticosteroids (OHCS) did not differ among the pregnant groups. These results indicate that elevated testosterone did not result from elevated maternal adrenal function. The feto-placental-ovarian unit and inhibition of aromatase activity and synthesis caused by diesel exhaust inhalation might have played an essential role in the accumulation of testosterone. Since both exhaust-exposed groups showed almost the same reactions toward the inhalation, the gaseous phase must have included the relevant toxicants.
Multicast and broadcast services in a knockout packet switch (2003)

The knockout switch is a packet-switch architecture recently proposed for high-performance packet networks. In addition to providing point-to-point connections among user pairs, a packet network must often support multicast and broadcast capabilities. Multicast connections differ from point-to-point connections in that each packet is addressed to a number of destinations. Two specific approaches using the knockout switch to provide a practical and efficient means for multicast services under both light and heavy traffic conditions are proposed. The first involves packet duplication and is more suitable for light traffic loads. The second uses a fast address comparison technique and is capable of handling larger loads. In both cases, the knockout principle is utilized to yield the best delay-throughput performance, guarantee the first-in first-out packet sequence, and provide for a simple, modular implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Posttranslationally modified bacteriocins—the lantibiotics (2000)

Lantibiotics are a subgroup of bacteriocins that are characterized by the presence of the unusual thioether amino acids lanthionine and 3-methyllanthionine generated through posttranslational modification. The biosynthesis of lantibiotics follows a defined pathway comprising modifications of the prepeptide, proteolytic activation, and export. The genes encoding the biosynthesis apparatus and the lantibiotic prepeptide are organized in clusters, which also include information for proteins involved in regulation and producer self-protection. The elongated cationic lantibiotics primarily act through the formation of pores and recent progress with nisin and epidermin has shown that specific docking molecules such as lipid II play an essential role in this mechanism. Mersacidin and actagardine inhibit cell wall biosynthesis by complexing the precursor lipid II, whereas the cinnamycin-like peptides bind to phosphoethanolamine thus inhibiting phospholipase A2.
STED nanoscopy: a glimpse into the future (2015)

The well-known saying of "Seeing is believing" became even more apt in biology when stimulated emission depletion (STED) nanoscopy was introduced in 1994 by the Nobel laureate S. Hell and coworkers. We presently stand at a juncture. Nanoscopy represented a revolution in fluorescence microscopy but now is a mature technique applied to many branches of biology, physics, chemistry, and materials science. We are currently looking ahead to the next generation of optical nanoscopes, to the new key player that will arise in the forthcoming years. This article gives an overview of the various cutting-edge implementations of STED nanoscopy and tries to shine a light into the future: imaging everything faster with unprecedented sensitivity and label-free.
<i>Edaphobacter</i> (2015)

Abstract E.da'pho.bac'ter. Gr. neut. n. edaphos soil; N.L. masc. n. bacter a short rod; N.L. masc. n. Edaphobacter rod of the soil. Rod‐shaped cells , 1.0–2.1 µm × 0.5–0.9 µm. Gram‐stain‐negative. Nonsporeforming. Cells occur singly or in clumps . Do not form capsule. Aerobic , having an obligately aerobic metabolism with oxygen as the terminal electron acceptor. Acidophilic . Growth at pH 4.0–7.0, with a pH optimum of 5.5. Catalase‐positive. Chemoorganotrophic. Growth on a variety of sugars, some amino acids, yeast extract, and peptone as the sole carbon source. Growth between 15 and 37°C, with a temperature optimum of 30°C. May be motile or nonmotile. Major fatty acids include C 16:1 ω7 c /C 15:0 iso 2‐OH and C 17:1 ω8 c . Isolated from mollisol on Jochberg in southern Germany and leptosol in a forest near Würzburg, Germany. DNA G + C content ( mol %): 55.8–56.9. Type species : Edaphobacter modestus Koch, Gich, Dunfield and Overmann 2008, 1121 VP . Taxonomic and Nomenclature Notes According to the List of Prokaryotic names with Standing in Nomenclature (LPSN), the taxonomic status of the genus Edaphobacter is: correct name (last update, February 2025) * . LPSN classification: Bacteria / Pseudomonadati / Acidobacteriota / Terriglobia / Terriglobales / Acidobacteriaceae / Edaphobacter The genus Edaphobacter can also be recovered in the Genome Taxonomy Database (GTDB) as g__Edaphobacter (version v220) ** . GTDB classification: d__Bacteria / p__Acidobacteriota / c__Terriglobia / o__Terriglobales / f__Acidobacteriaceae / g__Edaphobacter * Meier‐Kolthoff et al. ( 2022 ). Nucleic Acids Res , 50 , D801 – D807 ; DOI: 10.1093/nar/gkab902 ** Parks et al. ( 2022 ). Nucleic Acids Res , 50 , D785 – D794 ; DOI: 10.1093/nar/gkab776
Simulation Analysis of Dual Band Microstrip Antenna Strain Sensor Based on RFID (2019)

In this paper, a RFID antenna for structural health detection (SHM) is studied. The antenna is a dual frequency resonant antenna. In the simulation, the law of the strain of the dielectric plate is generated by the Poisson coefficient of the dielectric plate. The change in the shape of the antenna affects the electric current distribution on the antenna patch, causing the resonant frequency to drift, and further determining the nature of the strain through the return loss parameter. The simulation results show that the first resonant frequency of the microstrip antenna can be used to detect the direction of strain, and the second resonant frequency is used to detect the magnitude of strain. Compared with other products of the same type, the requirements of structural strain measurement can be met. It laid a theoretical foundation for experimental research.
Application of multiple-valued switch-level algebra to the design and analysis of pass-transistor switch networks (2002)

Pass-transistor switch networks have many advantages over gate-level networks, including high density, high speed, and low power dissipation. However, their design and analysis lack rigorous mathematical tools. A study is made of the application of the multiple-valued switch-level algebra introduced by M. Hu (1989) to the design and analysis of pass-transistor networks. After a brief introduction of the algebra, the design and analysis procedures are discussed in detail. Some design and analysis examples are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Actin-like filaments in bone cells of cultured mouse calvaria as demonstrated by binding to heavy meromyosin. (1975)

A variety of intracellular filaments (50-70 A in diameter) found in bone cells was shown to bind specifically to HMM. Because of this property, these filaments are probably biochemically similar to muscle actin. in osteoblasts and osteocytes, these reactive filaments were oriented in bundles parallel to the plasma membrane and filling the cell processes. In the osteoclast the filaments along the cell membrane were not so highly organized. In the clear zone, the quiescent part of the cell adjacent to the motile ruffled border, organized filament bundles were oriented perpendicular to the cell membrane and terminated in short processes at the bone surface. These filaments were also reactive with HMM. The possible significance of the filaments with respect to the physiology of bone cells is discussed.
On the Study of Oscillons in Scalar Field Theories: A New Approach (2016)

We study configurations in one-dimensional scalar field theory, which are time-dependent, localized in space, and extremely long-lived, called oscillons. How the action of changing the minimum value of the field configuration representing the oscillon affects its behavior is investigated. We find that one of the consequences of this procedure is the appearance of a pair of oscillon-like structures presenting different amplitudes and frequencies of oscillation. We also compare our analytical results to numerical ones, showing excellent agreement.
Functionalized Graphene as a Catalytic Counter Electrode in Dye-Sensitized Solar Cells (2010)

When applied on the counter electrode of a dye-sensitized solar cell, functionalized graphene sheets with oxygen-containing sites perform comparably to platinum (conversion efficiencies of 5.0 and 5.5%, respectively, at 100 mW cm(-2) AM1.5G simulated light). To interpret the catalytic activity of functionalized graphene sheets toward the reduction of triiodide, we propose a new electrochemical impedance spectroscopy equivalent circuit that matches the observed spectra features to the appropriate phenomena. Using cyclic voltammetry, we also show that tuning our material by increasing the amount of oxygen-containing functional groups can improve its apparent catalytic activity. Furthermore, we demonstrate that a functionalized graphene sheet based ink can serve as a catalytic, flexible, electrically conductive counter electrode material.
Back Cover: Sulfur and Nitrogen Dual‐Doped Mesoporous Graphene Electrocatalyst for Oxygen Reduction with Synergistically Enhanced Performance (Angew. Chem. Int. Ed. 46/2012) (2012)

Developing highly active and cheap catalysts for the oxygen reduction reaction (ORR) is crucial to the commercialization of fuel cells and lithium–air batteries. In their Communication on page 11496 ff., S. Z. Qiao et al. describe an inexpensive mesoporous graphene catalyst dual-doped with sulfur and nitrogen that has high ORR activity. The superior performance can be attributed to synergistic effects between the dopants, resulting in increased spin and charge densities.
Electrostatic enhancement of industrial drying processes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrostatic enhancement of industrial drying processesAtsuko Kirschvink-Kobayashi and Joseph L. KirschvinkCite this: Ind. Eng. Chem. Process Des. Dev. 1986, 25, 4, 1027–1030Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/i200035a030https://doi.org/10.1021/i200035a030research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Modeling visual attention's modulatory aftereffects on visual sensitivity and quality evaluation (2005)

With the fast development of visual noise-shaping related applications (visual compression, error resilience, watermarking, encryption, and display), there is an increasingly significant demand on incorporating perceptual characteristics into these applications for improved performance. In this paper, a very important mechanism of the human brain, visual attention, is introduced for visual sensitivity and visual quality evaluation. Based upon the analysis, a new numerical measure for visual attention's modulatory aftereffects, perceptual quality significance map (PQSM), is proposed. To a certain extent, the PQSM reflects the processing ability of the human brain on local visual contents statistically. The PQSM is generated with the integration of local perceptual stimuli from color contrast, texture contrast, motion, as well as cognitive features (skin color and face in this study). Experimental results with subjective viewing demonstrate the performance improvement on two PQSM-modulated visual sensitivity models and two PQSM-based visual quality metrics.
Procedures for Establishing Efficacy of Antimicrobial Agents for Chemotherapeutic Caries Prevention (1994)

Chemotherapeutics are presently considered for use in caries-preventive programs. The laboratory and in vivo testing of these agents, to some extent, parallels the methodology developed for the evaluation of fluoride products. However, fluoride is primarily effective by interfering with the de- and remineralization balance between enamel and the oral fluids. Antimicrobial and chemotherapeutic agents interfere with the bacterial colonization, growth, and metabolism of dental plaque. The initial selection of promising agents is done, therefore, by determination of the minimum inhibitory concentration (MIC) against a wide range of relevant bacterial species, together with tests of the effects of sub-MIC levels on the expression of virulence factors. In the hierarchy of tests proposed in this paper, studies of bacterial adhesion and enamel caries models form the next phase in the evaluation of agents. Also, mixed-culture studies are recommended to determine how a treatment perturbs a stable microflora. A final stage before clinical testing might involve intra-oral studies on limited numbers of volunteers. These should be tests of intra-oral substantivity and activity of the agents in formulated products, and in situ models of enamel caries lesion formation and remineralization. The latter type of study seems particularly appropriate to ensure that new agents do not decrease the efficacy of the other active components (e.g., fluoride) in caries-preventive products.
Elevated Expression of Galanin Receptors in Childhood Neuroblastic Tumors (2002)

The neuropeptide galanin (GAL) has been shown to be present in certain brain tumors. In order to learn more about GAL and its receptors in human tumors of the peripheral nervous system, we investigated the expression of the GAL peptide and the GAL receptors in tumor tissue from childhood neuroblastic tumors. GAL peptide concentrations up to 674 +/- 166 fmol/mg of tissue were detected by radioimmunoassay, but no significant correlation with standard tumor markers or the prognosis of the 14 patients investigated was observed. Ligand binding experiments showed different levels of GAL binding in all 28 primary neuroblastomas and 7 ganglioneuromas investigated. All three human GAL receptor subtypes cloned to date could be detected, with the GALR1 receptor subtype being expressed most prominently. GAL binding did not significantly correlate with genetic markers such as unfavorable DNA ploidy, amplification of the oncogene MYCN and allelic loss of chromosome 1p. However, low galanin binding was significantly correlated with survival (p = 0.021) in this limited analysis of neuroblastic tumor samples. These results raise the possibility that the expression of GAL binding sites may play a role in neuroblastic tumor biology and behavior.
The sequential generation of neutrophil chemoattractant proteins in acute inflammation in the rabbit in vivo. Relationship between C5a and proteins with the characteristics of IL-8/neutrophil-activating protein 1 (1991)

An in vivo experimental peritonitis model was investigated in the rabbit using zymosan as the inflammatory stimulus. After an i.p. injection of zymosan, exudate was removed at intervals and tested in the back skin of assay rabbits. Assay rabbits received i.v. injections of 125I-albumin and 111In-neutrophils, and the local accumulation of each label was measured in response to intradermal injections of exudate samples mixed with a potentiating dose of PGE2. When peritoneal exudate samples were tested in the presence of a specific anti-C5a antibody, virtually all the edema-inducing and neutrophil chemoattractant activity was abolished in samples taken up to 2 h after the zymosan injection. Later samples, however, contained increasing levels of a non-C5a component. In C5a-depleted 6-h exudate two peaks of inflammatory activity were separated using cation exchange HPLC. Evidence is presented that C5a itself is unable to stimulate the production of these activities. Both peaks of activity appear related to IL-8/NAP-1 as they inhibited the binding of 125I-IL-8/NAP-1 to human neutrophils.
Role of Phosphorylation on DNA Binding and Transcriptional Functions of Human Progesterone Receptors (1996)

To study the function of human progesterone receptor (hPR) phosphorylation, we have tested four sets of serine to alanine substitution mutants: 10 serine clusters, located in regions common to both hPR isoforms (the M-series mutants) were mutated in A-receptors and B-receptors; 6 serine clusters located in the B-upstream segment (BUS; the B-series mutants) were mutated individually and collectively and cloned into B-receptors and into BUS-DBD-NLS, a constitutive transactivator, in which the AF3 function of BUS is fused to the DNA binding domain (DBD) and nuclear localization signal (NLS) of hPR. Transcription by most of the M-series mutants resembles that of wild-type A- or B-receptors. Mutation of 3 sites, Ser190 at the N terminus of A-receptors, a cluster of serines just upstream of the DBD, or Ser676 in the hinge region, inhibits transcription by 20-50% depending on cell or promoter context. These sites lie outside the AF1 activation function. M-series mutants are substrates for a hormone-dependent phosphorylation step, and they all bind well to DNA. Progressive mutation of the B-series clusters leads to the gradual dephosphorylation of BUS, but only the 6-site mutant, involving 10 serine residues, is completely dephosphorylated. These data suggest that in BUS alternate serines are phosphorylated or dephosphorylated at any time. However, even when BUS is completely dephosphorylated, both BUS-DBD-NLS and full-length B-receptors remain strong transactivators. Mutant B-receptors also do not acquire the dominant negative properties of A-receptors, and they retain the ability to activate transcription in synergy with 8-Br-cAMP and antiprogestins. We conclude that phosphorylation has subtle effects on the complex transcriptional repertoire that distinguishes the two hPR isoforms and does not influence transactivation mediated by AF1 or AF3, but subserves other functions.
An extended completeness condition for exact cone-beam reconstruction and its application (2002)

The completeness condition is an important concept that specifies the capability of exact image reconstruction from a set of cone-beam projections. Unfortunately, the existing completeness conditions associated with Tuy's (1983), Smith's (1985), and Grangeat's (1991) inversion formulae are too restrictive in various situations where some projections are partially measured. The authors derive an extended completeness condition that improves the existing results. The new condition is a direct consequence of a reconstruction algorithm that is in the form of space-variant filtering followed by cone-beam backprojection. The new condition is less restrictive compared with the existing ones and provides an effective means to incorporate partially measured projections into image reconstruction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A case for NOW (Networks of Workstations) (1995)

Networks of workstations are poised to become the primary computing infrastructure for science and engineering. NOWs may dramatically improve virtual memory and file system performance; achieve cheap, highly available, and scalable file storage: and provide multiple CPUs for parallel computing. Hurdles that remain include efficient communication hardware and software, global coordination of multiple workstation operating systems, and enterprise-scale network file systems. Our 100-node NOW prototype aims to demonstrate practical solutions to these challenges.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>