gebhart/patrepeval huggingface dataset:
Elimination of transverse coherences in FLASH MRI (1988)

Fast low-angle shot (FLASH) imaging enables T1-weighted scans to be acquired in a few seconds. However, the diagnostic image quality is severely compromised by the appearance of artifactual bands parallel to the frequency encode direction. We show that the band structure arises from differences in the ability of the phase encode gradient to spoil transverse coherences that build up between successive repetition intervals. A theoretical understanding of the mechanisms involved leads to a comparison between various methods of spoiling the unwanted echoes throughout the whole field of view. Spoiler gradients whose amplitudes change linearly with phase encode step number are treated in detail. The theory predicts that the spoilers will rotate and rescale the band structure and these results are confirmed experimentally. The effect of the spoilers at a given location along the gradient is equivalent to the effect on the entire field of view of an incremented phase shift applied to the radiofrequency pulse. An appropriate rf phase shift scheme should therefore provide ideal spoiling characteristics for FLASH imaging.
Towards efficient and reliable 300mm 3D technology for wide I/O interconnects (2012)

This paper presents the prototype of a 3D circuit with Wide I/O interconnects in a 65nm CMOS node, assembled in a face-to-back integration and reported on a BGA. The process technology carried out for the realization of the bottom die will be presented in both 200mm and 300mm environment. Finally, the 3D assembly will be successfully assessed through electrical and reliability tests, concretising the realism of a 3D technology for future Wide I/O products.
Movement Type Prediction before Its Onset Using Signals from Prefrontal Area: An Electrocorticography Study (2014)

Power changes in specific frequency bands are typical brain responses during motor planning or preparation. Many studies have demonstrated that, in addition to the premotor, supplementary motor, and primary sensorimotor areas, the prefrontal area contributes to generating such responses. However, most brain-computer interface (BCI) studies have focused on the primary sensorimotor area and have estimated movements using postonset period brain signals. Our aim was to determine whether the prefrontal area could contribute to the prediction of voluntary movement types before movement onset. In our study, electrocorticography (ECoG) was recorded from six epilepsy patients while performing two self-paced tasks: hand grasping and elbow flexion. The prefrontal area was sufficient to allow classification of different movements through the area's premovement signals (-2.0 s to 0 s) in four subjects. The most pronounced power difference frequency band was the beta band (13-30 Hz). The movement prediction rate during single trial estimation averaged 74% across the six subjects. Our results suggest that premovement signals in the prefrontal area are useful in distinguishing different movement tasks and that the beta band is the most informative for prediction of movement type before movement onset.
Advanced Package Technologies for High-Performance Systems (2005)

Microelectronic packages continue to undergo significant changes to keep pace with the demands of high- performance silicon. From the traditional role of space transformation and mechanical protection, packages have evolved to be a means to cost-effectively manage the increasing demands of power delivery, signal distribution, and heat removal. In the last decade or so, increasing frequency and power levels coupled with lower product costs have been driving new package technologies. Some examples of this are the migration from wirebond to flip chip interconnect and ceramic to organic package substrates. Recently, architectural changes like the introduction of multicore processors, material changes such as the low-K dielectrics on the silicon, and lead-free second-level interconnects have introduced a new set of challenges that require innovative package technology solutions. As we look forward, increased levels of current, increased power density, and high-bandwidth signaling are expected to create challenges in all disciplines within the package field. In addition to these technical challenges, market forces such as declining computer prices, increased user experience through miniaturized devices, wireless connectivity, and longer battery life would make these challenges even more complex. In this paper we provide an overview of trends and challenges in the areas of power delivery, signal transfer, thermal management, miniaturization, and wireless package technologies. We also examine some of the potential solutions that are being developed to meet these challenges.
Fabry-Perot liquid crystal tunable filter for interrogation of multiple fibre Bragg grating sensors (2007)

In this paper we analyze the performance of a fibre Bragg grating (FBG) interrogation system based on a liquid crystal tunable filter (LCTF), which acts as a channel dropper for multiple FBG sensors coupled to a simple all-fibre ratiometric wavelength measurement scheme in which a macrobending single-mode fibre is utilized as an edge filter. We present a model of the proposed interrogation scheme and analyse the optimum design parameters for the LCTF. From the model, the optimum ratio between the number of FBG sensors and the tunable filter bandpass can be found. Experimental results for the wavelength interrogation system are presented to validate the theoretical predictions. The model should be also suitable for similar interrogation systems using other forms of tunable bandpass filters.
Synthesis and Properties of Random Copolymers of Functionalised Polybenzimidazoles for High Temperature Fuel Cells (2011)

Abstract A series of polybenzimidazoles (PBIs) incorporating main chain sulphonic acid groups were synthesised as random copolymers with p ‐PBI in varying ratios using polyphosphoric acid (PPA) as both the polymerisation solvent and polycondensation reagent. The PPA process was used to produce high molecular weight phosphoric acid (PA) doped PBI gel membranes in a one‐step procedure. These membranes exhibit excellent mechanical properties (0.528–2.51 MPa tensile stress and 130–300% tensile strain) even at high acid doping levels [20–40 mol PA/PRU (polymer repeat unit)] and high conductivities (0.148–0.291 S cm –1 ) at elevated temperatures (>100 °C) with no external humidification, depending on copolymer composition. Fuel cell testing was conducted with hydrogen fuel and air or oxygen oxidants for all membrane compositions at temperatures greater than 100 °C without external feed gas humidification. Initial studies showed a maximum fuel performance of 0.675 V for the 25 mol% s‐PBI/75 mol% p ‐PBI random copolymer at 180 °C and 0.2 A cm –2 with hydrogen and air, and 0.747 V for the same copolymer at 180 °C and 0.2 A cm –2 with hydrogen and oxygen.
Prospective evaluation of the clinical usefulness of an antigen- specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias (1996)

The diagnosis of idiopathic immune thrombocytopenia remains a clinical diagnosis based on the exclusion of other causes of immune and nonimmune thrombocytopenia. Measurement of platelet-associated Ig (PAIg), while sensitive, is nonspecific for the diagnosis of immune thrombocytopenia. Published experience of antigen capture assays (including monoclonal antibody immobilization of platelet antigens or MAIPA) suggest a high sensitivity and specificity (70% to 80%) in selected groups of patients. In a prospective evaluation of 158 patients with thrombocytopenia from all causes, we report a sensitivity of 51% and specificity of 80% for direct MAIPA assays. MAIPA was considerably better in discriminating immune from nonimmune thrombocytopenia than two assays of PAIgG. Antiplatelet antibodies detected by MAIPA were more frequently directed against the glycoprotein (GP) IIb/IIIa than the GP Ib/IX complex. Our experience suggests that MAIPA assays are useful in the laboratory assessment of thrombocytopenia, should be performed before therapy, and that some patients with 'nonimmune' thrombocytopenia may have genuine antiplatelet antibodies.
Editorial (2009)

This is the editorial for the special issue entitled ``Modelling, Monitoring and Fault-Tolerant Control for Complex Systems'' published in the Open Automation and Control Systems Journal.
Functional phenotype of phosphoinositide 3-kinase p85 -null platelets characterized by an impaired response to GP VI stimulation (2003)

Phosphoinositide 3-kinases (PI3Ks), a family of lipid kinases comprising 3 classes with multiple isoforms, have been shown to participate in different phases of platelet signaling. To investigate the roles that enzymes play in platelet function in vivo and determine which isoforms are important for particular signaling events, we analyzed platelet function of gene knockout mice deficient in the p85alpha regulatory subunit of heterodimeric class IA PI3K. The kinase activity of p85alpha-/- platelets was only 5% of the activity of platelets from wild-type littermates. Platelet aggregation induced by adenosine diphosphate (ADP), thrombin, U46619, phorbol 12-myristate 13-acetate (PMA), or botrocetin was not defective in p85alpha-/- mice, compared with wild-type animals. In contrast, aggregation induced by collagen and collagen-related peptide (CRP) was partially but readily impaired in p85alpha-/- mice. Both P-selectin expression and fibrinogen binding in response to CRP were also decreased to a similar extent in p85alpha-/- platelets. Platelets from p85alpha-/- mice appeared to spread poorly over a CRP-coated surface with intact filopodial protrusions. Significant attenuation of CRP-induced tyrosine phosphorylation in known PI3K effectors such as Btk, Tec, PKB/Akt, and phospholipase Cgamma2 were observed with p85alpha-/- platelets, whereas no alteration was noted in upstream molecules of Syk, LAT, and SLP-76. Considered as a whole, these results provide the first genetic evidence that PI3K p85alpha plays a significant role in platelet function, almost exclusively in the glycoprotein (GP) VI/Fc receptor gamma chain complex-mediated signaling pathway.
Decreased Production Rates of VLDL Triglycerides and ApoB-100 in Subjects Heterozygous for Familial Hypobetalipoproteinemia (1999)

Familial hypobetalipoproteinemia (FHBL) is an autosomal codominant disorder characterized by low levels of apolipoprotein (apo) B and low-density lipoprotein (LDL) cholesterol. Decreased production rates of apoB have been demonstrated in vivo in FHBL heterozygotes. In the present study, we wished to investigate whether the transport of triglycerides was similarly affected in these subjects. Therefore, we studied the in vivo kinetics of very-low-density lipoprotein (VLDL) triglycerides and VLDL apoB-100 simultaneously in 7 FHBL heterozygotes from 2 well-characterized kindreds and 7 healthy normolipidemic subjects. In both kindreds, hypobetalipoproteinemia is caused by mutations in the 5' portion of the apoB gene specifying short truncations of apoB undetectable in plasma. A bolus injection of deuterated palmitate and a primed constant infusion of deuterated leucine were given simultaneously, and their incorporation into VLDL triglycerides and VLDL apoB, respectively, were determined by gas chromatography-mass spectrometry. Kinetic parameters were calculated by using compartmental modeling. VLDL apoB fractional catabolic rates (FCRs) in FHBL heterozygotes and controls were similar (11. 6+/-3.9 and 10.9+/-2.4 pools per day, respectively, P=0.72). On the other hand, FHBL heterozygotes had a 75% decrease in VLDL apoB production rates compared with normal subjects (5.8+/-1.8 versus 23.4+/-7.1 mg/kg per day, P<0.001). The decreased production rates of VLDL apoB accounts for the very low concentrations of plasma apoB found in heterozygotes from these kindreds (24% of normal). Mean VLDL triglyceride FCRs in FHBL subjects and controls were not significantly different (1.06+/-0.74 versus 0.89+/-0.50 pools per hour, respectively, P=0.61). There was a good correlation between VLDL apoB FCR and VLDL triglyceride FCR in the 2 groups (r=0.84, P<0. 001). VLDL triglyceride production rates were decreased by 60% in FHBL heterozygotes compared with controls (9.3+/-6.0 versus 23.0+/-9. 6 micromol/kg per hour, P=0.008). Thus, the hepatic secretion of VLDL triglycerides is reduced in FHBL heterozygotes but to a lesser extent than the decrease in apoB-100 secretion. This is probably achieved by the secretion of VLDL particles enriched with triglycerides.
Immunoinformatics‐aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019‐nCoV (2020)

The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV surface glycoprotein. Also, interactions between identified CTL epitopes and their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent in China were studied by molecular dynamics simulations. We identified five CTL epitopes, three sequential B cell epitopes and five discontinuous B cell epitopes in the viral surface glycoprotein. Also, during simulations, the CTL epitopes were observed to be binding MHC class I peptide-binding grooves via multiple contacts, with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these identified epitopes can be potential candidates for the development of 2019-nCoV vaccines.
Encapsulation Methods for Transport of Ethernet over MPLS Networks (2006)

An Ethernet pseudowire (PW) is used to carry Ethernet/802.3 Protocol Data Units (PDUs) over an MPLS network. This enables service providers to offer "emulated" Ethernet services over existing MPLS networks. This document specifies the encapsulation of Ethernet/802.3 PDUs within a pseudowire. It also specifies the procedures for using a PW to provide a "point-to-point Ethernet" service.
Quantum computational finance: Monte Carlo pricing of financial derivatives (2018)

This work presents a quantum algorithm for the Monte Carlo pricing of financial derivatives. We show how the relevant probability distributions can be prepared in quantum superposition, the payoff functions can be implemented via quantum circuits, and the price of financial derivatives can be extracted via quantum measurements. We show how the amplitude estimation algorithm can be applied to achieve a quadratic quantum speedup in the number of steps required to obtain an estimate for the price with high confidence. This work provides a starting point for further research at the interface of quantum computing and finance.
Converter Volt-Ampere Requirements of the Switched Reluctance Motor Drive (1985)

An algebraic nonlinear analysis of the switched reluctance drive system is described. The analysis is intended to provide an understanding of the factors that determine the kVA requirements of the electronic power converter and to determine the fundamental nature of the torque/speed characteristics. The effect of saturation is given special attention. It is shown that saturation has the two main effects of increasing the motor size required for a given torque, and at the same time decreasing the kVA per horsepower (i.e., increasing the effective power factor by analogy with an ac machine). The kVA per horsepower is lower than predicted by simple linear analysis that neglects saturation. Necessary conditions are also developed for a flat-topped current waveform by correctly determining the motor back-EMF. The reason why it is desirable to allow the phase current to continue (though with much reduced magnitude) even after the poles have passed the aligned position is explained. The theory provides a formula for determining the required commutation angle for the phase current. The basis is provided for an estimation of the kVA requirements of the switched reluctance (SR) drive. These requirements have been measured and also calculated by a computer simulation program.
Glycohemoglobin and glucose tolerance tests compared as indicators of borderline diabetes. (1979)

We concurrently measured glycohemoglobin and performed 3-h oral (100 g) glucose tolerance tests on 69 ambulatory patients suspected of having abnormal carbohydrate metabolism. The patients were divided into two groups: (a) The 37 patients for whom the results were normal had plasma glucose concentrations of 0.70--1.15 milligram during fasting and 0.70--1.23 g/L 2 h after glucose ingestion. (b) Borderline diabetics exceeded one or both of these limits. The range of glycohemoglobin in the normal group was 3.0--4.7% of total hemoglobin. Of the 21 borderline diabetics, 11 had increased glycohemoglobin (4.8--8.0%). The difference in tolerance test results between borderline diabetics with and without increased glycohemoglobin was insufficient to predict the status of glycohemoglobin. We suggest a tentative definition for latent diabetes: increased glycohemoglobin in the presence of normal or borderline-abnormal glucose concentration in plasma collected during fasting.
Enhanced Chondrogenesis of Induced Pluripotent Stem Cells From Patients With Neonatal‐Onset Multisystem Inflammatory Disease Occurs via the Caspase 1–Independent cAMP/Protein Kinase A/CREB Pathway (2014)

Our findings indicate that the intrinsic hyperplastic capacity of NOMID chondrocytes is dependent on the cAMP/PKA/CREB pathway, independent of the NLRP3 inflammasome.
A 32b floating point CMOS digital signal processor (1986)

A 1.5μm CMOS digital signal processor with 150ns instruction cycle time will be reported. The chip contains a 32b floating point parallel multiplier and a 55b floating point ALU. The IC contains 370K transistors.
Extremely low power c-axis aligned crystalline In-Ga-Zn-O 60 nm transistor integrated with industry 65 nm Si MOSFET for IoT normally-off CPU application (2016)

For the first time, laboratory 60 nm c-axis aligned crystalline In-Ga-Zn-O (CAAC-IGZO) oxide semiconductor FET (OSFET) was successfully integrated with industrial 65 nm Si MOSFET (SiFET). By this hybrid process, OSFET with extremely low off-state leakage level ~zA (1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-21</sup> A) was fabricated, while traditional Si device can only reach 1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> A leakage level. For IoT (Internet of Things) applications, normally-off CPU (Noff CPU) fabricated by this hybrid process achieved 86% reduction of power consumption. The hybrid process can be extended to other applications like eDRAM, image sensor and FPGA.
Interleukin-1 Promotes Coagulation, Which Is Necessary for Protective Immunity in the Lung Against Streptococcus pneumoniae Infection (2012)

Interleukin (IL)-1 is a well-known cytokine for the initiation of innate immunity in bacterial infection. However, the underlying mechanism of IL-1 on the respiratory infection is not fully elucidated. We studied how IL-1 contributes to the host defense against Streptococcus pneumoniae. IL-1R(-/-) mice showed high mortality, local cytokine storm, and substantial infiltrates in the lower respiratory tract after intratracheal challenge with S. pneumoniae. The IL-1-deficient condition did not suppress the propagation of bacteria in the lung, although the recruitment and the bacteria-killing ability of neutrophils (CD11b(+)Ly6C(+)Ly6G(+)) were not defective compared with wild-type mice. Unexpectedly, we found that the transcription of fibrinogen alpha and gamma genes were highly activated in the lungs of wild-type mice after the infection, whereas no significant changes were found in IL-1R(-/-) mice. Of note, synthesis of fibrinogen was dependent on the IL-1-IL-6-Stat3 cascade. Treatment with recombinant fibrinogen improved survival and bacterial propagation in the IL-1R(-/-) mice and blockade of the coagulation increased the susceptibility of wild-type mice to pneumococcal pneumonia. Our findings suggest that IL-1 signaling leads to the synthesis of fibrinogen in the lung after pneumococcus infection and is followed by coagulation, which contributes to the control of bacterial infection in the pulmonary tract.
New statistical approach in biochemical method-comparison studies by using Westlake's procedure, and its application to continuous-flow, centrifugal analysis, and multilayer film analysis techniques. (1983)

In this paper, we present an application of Westlake's method (Biometrics 32:741, 1976) in method-comparison studies in clinical chemistry. The techniques under study are continuous flow (CF), centrifugal analysis (CA), and multilayer film analysis (the Kodak Ektachem procedure KE). The experimental data are for plasma calcium and serum uric acid. It results from a particular regression procedure proposed by York (Can J Phys 44:1079, 1966) that the usual regression comparison technique (joint testing procedure) is irrelevant because it rejects the identity hypothesis for the three methods, whereas fixing a tolerable upper limit deviation, delta, between two methods would lead to the conclusion that, in 95% of cases, CF and KE results are equivalent for plasma calcium (delta less than or equal to 45 mumol/L) and CF is roughly equivalent to the other two methods for serum uric acid (delta less than or equal to 27 mumol/L).
Quantitative left ventricular wall motion analysis: a comparison of area, chord and radial methods. (1979)

We were interested in divising a relatively simple quantitative technique that could be used on a routine clinical basis for wall motion analysis. Three quantitative methods of left ventricular (LV) regional analysis were compared in the 30 degrees right anterior oblique and 60 degrees left anterior oblique projection. The control group consisted of 17 patients with qualitatively normal LV wall motion; the abnormal group comprised 17 patients with at least one region of severe, qualitative wall motion abnormality. Normal regional values were determined for area, chord and radial methods by applying the techniques to the ventriculograms of the control group. Each technique was then applied to the abnormal group's ventriculograms to determine the percentage of qualitatively abnormal regions not detected by each method. The area method had the lowest failure rate (p less than 0.001) and the best separation of measured normal and abnormal regions' ejection changes (p less than 0.001), and best reflected symmetric uniform motion of the ventricular silhouette. We conclude that the area method, of the techniques examined, was best for the quantitative analysis of LV wall motion abnormalities.
Morphone.OS: Context-Awareness in Everyday Life (2013)

Mobile devices, due to their wide distribution and to their increasing smartness and availability of computational power, can become the interaction point between users and their surrounding environments. However, current mobile devices OSes lack of the ability to anticipate and overcome internal and external changes. Integrating mechanisms of self-awareness and self-adaptability in nowadays smartphones is an attractive perspective to match with these requirements. Moreover, adaptive behaviors can enhance the management by the mobile device itself, of the available resources at its best, e.g., the battery life. This paper envisions various situations in which a self-aware mobile device can interact with the surrounding environment and support the user in performing everyday actions. A prototype of such an adaptive device, called morphone.os and based on the Android OS, has been designed and implemented to verify the reaction of the device in different situations providing convincing and promising preliminary results.