gebhart/patrepeval huggingface dataset:
Immunoassay of serum galactosyltransferase isoenzyme II in cancer patients and control subjects. (1988)

Serum galactosyltransferase isoenzyme II (GT-II) was assayed in 409 coded serum samples obtained from the National Cancer Institute Tumor Serum Bank using a monoclonal antibody-based immunoassay. The serum panel consisted of samples from patients with confirmed, metastatic ovarian, breast, stomach, esophageal, pancreatic, lung, colorectal, bladder, prostate, and cervical cancer, as well as benign disease controls corresponding to each cancer type, and confirmed healthy normal controls. The serum panel was matched for age and sex; 176 of 179 cancer patients had metastatic disease, and many had undergone previous therapy. GT-II was significantly elevated (P less than 0.01) in all pairwise tests (Wilcoxon) comparing cancer cases with normals and cancer cases with benign disease cases of the same site. A cutpoint of 200 milliunits of GT-II activity/ml of serum was selected, and only one of 50 normal control sera was elevated above this value, yielding a specificity of 98%. The overall sensitivity of the GT-II assay was 55.3%, with higher sensitivity shown by pancreatic (77%), prostate (65%), esophageal (64%), cervical (59%), and bladder cancer (58%).
Sex Differences in Characteristics, Outcomes, and Treatment Response With Dapagliflozin Across the Range of Ejection Fraction in Patients With Heart Failure: Insights From DAPA-HF and DELIVER (2022)

In DAPA-HF and DELIVER, the response to dapagliflozin was similar between men and women. Sex did not modify the treatment effect of dapagliflozin across the range of ejection fraction.
ARMA time-series modeling with graphical models (2004)

We express the classic ARMA time-series model as a directed graphical model. In doing so, we find that the deterministic relationships in the model make it effectively impossible to use the EM algorithm for learning model parameters. To remedy this problem, we replace the deterministic relationships with Gaussian distributions having a small variance, yielding the stochastic ARMA (σARMA) model. This modification allows us to use the EM algorithm to learn parameters and to forecast, even in situations where some data is missing. This modification, in conjunction with the graphical-model approach, also allows us to include cross predictors in situations where there are multiple time series and/or additional non-temporal covariates. More surprising, experiments suggest that the move to stochastic ARMA yields improved accuracy through better smoothing. We demonstrate improvements afforded by cross prediction and better smoothing on real data.
Multi-Gbps wireless systems over 60-GHz SiGe radio link with BW-efficient noncoherent detections (2008)

This paper describes a demonstration of multi-Gbps wireless systems using 60-GHz SiGe radio chipsets with noncoherent detection techniques. The modulation and demodulation are performed with BW-efficient frequency-shift keying schemes, such as MSK, by partitioning the function into the radio chip and baseband FPGA. With integrated mixer/sign modulator and appropriate precoder, an IQ-based radio interface is used in TX, while the noncoherent detections are achieved by using FM discriminator and CDR (Clock Data Recovery) in RX. As a result, multi-Gbps data rate systems can be built without using high sampling rate ADC/DAC, and the efficiency better than ASK or FSK modulation schemes is achieved.
EVALUATION IN MICE OF THE IMMUNOGENICITY AND PROTECTIVE EFFICACY OF A TETRAVALENT SUBUNIT VACCINE CANDIDATE AGAINST DENGUE VIRUS (2014)

Introduction : A dengue vaccine must induce protective immunity against the four serotypes of the virus. Our group has developed chimeric proteins consisting of the protein P64k from Neisseria meningitidis and the domain III from the four viral envelope proteins. Objectives : In this study, the immunogenicity of a tetravalent vaccine formulation using aluminum hydroxide as adjuvant was evaluated in mice. Results: After three doses, neutralizing antibody titers were detected against the four viral serotypes, the lowest seroconversion rate being against dengue virus serotype 4. One month after the last dose, immunized animals were challenged with infective virus, and partial but statistically significant protection was found to have been achieved. Conclusions: Based on these results, further studies in mice and non-human primates using this tetravalent formulation in a prime-boost strategy with attenuated viruses are strongly recommended.
Orthogonal Time Frequency Space Modulation (2017)

A new two-dimensional modulation technique called Orthogonal Time Frequency Space (OTFS) modulation designed in the delay-Doppler domain is introduced. Through this design, which exploits full diversity over time and frequency, OTFS coupled with equalization converts the fading, time-varying wireless channel experienced by modulated signals such as OFDM into a time-independent channel with a complex channel gain that is roughly constant for all symbols. Thus, transmitter adaptation is not needed. This extraction of the full channel diversity allows OTFS to greatly simplify system operation and significantly improves performance, particular in systems with high Doppler, short packets, and large antenna arrays. Simulation results indicate at least several dB of block error rate performance improvement for OTFS over OFDM in all of these settings. In addition these results show that even at very high Dopplers (500 Km/h), OTFS approaches channel capacity through linear scaling of throughput with the MIMO order, whereas the performance of OFDM under typical design parameters breaks down completely.
Propagation sampled acoustic line array (1980)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation William L. Konrad; Propagation sampled acoustic line array. J. Acoust. Soc. Am. 1 June 1980; 67 (6): 2126. https://doi.org/10.1121/1.384386 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Partially coherent illumination in full-field interferometric synthetic aperture microscopy (2009)

A model is developed for optical coherence tomography and interferometric synthetic aperture microscopy (ISAM) systems employing full-field frequency-scanned illumination with partial spatial coherence. This model is used to derive efficient ISAM inverse scattering algorithms that give diffraction-limited resolution in regions typically regarded as out of focus. Partial spatial coherence of the source is shown to have the advantage of mitigating multiple-scattering effects that can otherwise produce significant artifacts in full-field coherent imaging.
Identification of Molecular Predictors of Response to ZARNESTRA™ (Tipifarnib, R115777) in Relapsed and Refractory Acute Myeloid Leukemia. (2004)

Abstract The orally available farnesyltransferase inhibitor (FTI) tipifarnib has demonstrated clinical efficacy in hematological disease. In an effort to identify patients with a higher likelihood of response, we have employed microarray technology to identify gene expression markers that predict response to tipifarnib. In an open label, single arm, Phase II study of patients with relapsed or refractory acute myeloid leukemia, tipifarnib was administered at a dose of 600 mg twice daily for the first 21 days of each 28-day cycle. Gene expression profiles from 80 bone marrow samples, collected before drug treatment, were analyzed on the Affymetrix U133A gene chip that contains approximately 22,000 genes. Statistical analyses were performed to identify genes that predict patient outcome following treatment with tipifarnib. Nineteen genes were selected because they showed significant differences in gene expression between the responder group and the non-responder group of patients. Several of these genes are associated with oncogenesis, cell proliferation, and FTI biology. One of the candidate genes, lymphoid blast crisis oncogene (oncoLBC or AKAP13), was over-expressed in patients who were resistant to tipifarnib. A leave-one-out cross validation (LOOCV) showed that the predictive value of this gene provided a sensitivity of 93% in identifying responders and a specificity of 61%, providing an overall diagnostic accuracy of 69%. In addition, supervised analysis identified a combination of 3 gene expression markers that together can potentially be used to predict patient response to the drug with the best overall accuracy of 74%. This 3-gene expression signature provided a sensitivity of 86% and a specificity of 70% in the LOOCV. In both instances, classification of patients using the gene expression signatures demonstrated significantly enhanced overall survival in those predicted to be responders. These data indicate that diagnostic gene expression signatures can potentially double the response rate to tipifarnib from 24% to 48%. The identification of these gene expression markers is an important step towards defining diagnostic signatures that could be used to identify AML patients who are likely to respond to tipifarnib and for understanding pathways that are affected by farnesyltransferase inhibition in AML.
Inhibition of Listeria monocytogenes by using bacteriocin PA-1 produced by Pediococcus acidilactici PAC 1.0 (1988)

The bacteriocin produced by Pediococcus acidilactici PAC 1.0, previously designated PA-1 bacteriocin, was found to be inhibitory and bactericidal for Listeria monocytogenes. A dried powder prepared from PAC 1.0 culture supernatant fortified with 10% milk powder was found to contain bacteriocin activity. An MIC against L. monocytogenes and lytic effects in broth cultures were determined. Inhibition by PA-1 powder occurred over the pH range 5.5 to 7.0 and at both 4 and 32 degrees C. In addition, inhibition of L. monocytogenes was demonstrated in several food systems including dressed cottage cheese, half-and-half cream, and cheese sauce.
An Ultrasonic Transducer with Gaussian Radial Velocity Distribution (1981)

A transducer with a velocity profile which is Gaussian as a function of radius and independent of angle is described. In materials evaluation applications requiring the interrogation of modified far field patterns of an ultrasonic transducer, it is desirable to use a transducer which produces a beam with a Gaussian profile. A computer aided electrode design and calibrated three dimensional interferometric optical and ultrasonic measurements of the far field distribution are presented.
Joint Resource and Power Allocation Technique for Downlink Power-Domain Non-Orthogonal Multiple Access (2018)

In this paper, a novel resource and power allocation technique is proposed for a power-domain non-orthogonal multiple access scheme using successive interference cancellation in a downlink cellular system. It aims at providing a flexible balancing between throughput and fairness maximization and incorporates unequal power repartition among allocated subbands using waterfilling. Its main strength is the ability to achieve a high level of fairness in every scheduling slot, therefore improving the quality of experience for all users. Simulation results show that the proposed metric enhances fairness and improves system capacity, when compared to the conventional proportional fairness scheduler.
Electrically resonant terahertz metamaterials: Theoretical and experimental investigations (2007)

We present a class of artificial materials that exhibit a tailored response to the electrical component of electromagnetic radiation. These electric metamaterials are investigated theoretically, computationally, and experimentally using terahertz time-domain spectroscopy. These structures display a resonant response including regions of negative permittivity ${ϵ}_{1}(\ensuremath{\omega})<0$ ranging from $\ensuremath{\sim}500\phantom{\rule{0.3em}{0ex}}\mathrm{GHz}\phantom{\rule{0.3em}{0ex}}\text{to}\phantom{\rule{0.3em}{0ex}}1\phantom{\rule{0.3em}{0ex}}\mathrm{THz}$. Conventional electric media such as distributed wires are difficult to incorporate into metamaterials. In contrast, these localized structures will simplify the construction of future metamaterials, including those with negative index of refraction. As these structures generalize to three dimensions in a straightforward manner, they will significantly enhance the design and fabrication of functional terahertz devices.
<i>In vivo</i> pharmacological characterization of the non‐peptide endothelin receptor antagonist SB 209670 (1995)

1. The aim of the present study was to assess the ability of SB 209670, a high affinity non-peptide endothelin receptor antagonist (0.4 and 18 nM Kis at human cloned ETA and ETB receptors, respectively), to inhibit the haemodynamic actions of endothelin-1 in vivo. 2. Systemic administration of (+/-)-SB 209670, given either as a bolus i.v. injection or as a continuous i.v. infusion, did not alter basal haemodynamic parameters in the anaesthetized rat. 3. Infusion of (+/-)-SB 209670 (10 micrograms kg-1 min-1) selectively inhibited the depressor and carotid vasodilator response to exogenous endothelin-1: 100 micrograms kg-1 min-1 was required to inhibit significantly the biphasic haemodynamic actions of endothelin-1. The haemodynamic actions of angiotensin II and calcitonin gene-related peptide were unaltered by 100 micrograms kg-1 min-1 (+/-)-SB 209670. 4. Bolus i.v. administration of (+/-)-SB 209670 (1 mg kg-1) selectively inhibited the depressor and carotid vasodilator actions of endothelin-1: 10 mg kg-1 (+/-)-SB 209670 was required to inhibit the secondary vasoconstrictor actions of endothelin-1. 5. (+/-)-SB 209670 (10 mg kg-1) was also effective at antagonizing the pressor actions of endothelin-1 in the conscious rat for up to 3 h after intraduodenal administration thereby demonstrating that the antagonist was bioavailable upon enteric administration. This dose of (+/-)-SB 209670 did not alter basal haemodynamic parameters in the conscious rat. 6. Thus, ( +/- )-SB 209670 is an effective endothelin receptor antagonist in vivo. Using the doses defined in this study, SB 209670 may, therefore, serve as a useful tool for understanding the role of endogenous endothelin-I in the control of cardiovascular function under both physiological and pathophysiological conditions.
Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors (2015)

RIPK2 mediates pro-inflammatory signaling from the bacterial sensors NOD1 and NOD2, and is an emerging therapeutic target in autoimmune and inflammatory diseases. We observed that cellular RIPK2 can be potently inhibited by type II inhibitors that displace the kinase activation segment, whereas ATP-competitive type I inhibition was only poorly effective. The most potent RIPK2 inhibitors were the US Food and Drug Administration-approved drugs ponatinib and regorafenib. Their mechanism of action was independent of NOD2 interaction and involved loss of downstream kinase activation as evidenced by lack of RIPK2 autophosphorylation. Notably, these molecules also blocked RIPK2 ubiquitination and, consequently, inflammatory nuclear factor κB signaling. In monocytes, the inhibitors selectively blocked NOD-dependent tumor necrosis factor production without affecting lipopolysaccharide-dependent pathways. We also determined the first crystal structure of RIPK2 bound to ponatinib, and identified an allosteric site for inhibitor development. These results highlight the potential for type II inhibitors to treat indications of RIPK2 activation as well as inflammation-associated cancers.
STAND: Sanitization Tool for ANomaly Detection (2007)

The efficacy of Anomaly Detection (AD) sensors depends heavily on the quality of the data used to train them. Artificial or contrived training data may not provide a realistic view of the deployment environment. Most realistic data sets are dirty; that is, they contain a number of attacks or anomalous events. The size of these high-quality training data sets makes manual removal or labeling of attack data infeasible. As a result, sensors trained on this data can miss attacks and their variations. We propose extending the training phase of AD sensors (in a manner agnostic to the underlying AD algorithm) to include a sanitization phase. This phase generates multiple models conditioned on small slices of the training data. We use these "micro-models"Â to produce provisional labels for each training input, and we combine the micro-models in a voting scheme to determine which parts of the training data may represent attacks. Our results suggest that this phase automatically and significantly improves the quality of unlabeled training data by making it as "attack-free"Â and "regular"Â as possible in the absence of absolute ground truth. We also show how a collaborative approach that combines models from different networks or domains can further refine the sanitization process to thwart targeted training or mimicry attacks against a single site.
Automated Estimation of Average Stopped Delay at Signalized Intersections Using Digitized Still-Image Analysis of Actual Traffic Flow (2006)

Average stopped delay for a given signalized intersection approach is the average time a vehicle waits at a traffic light and constitutes a part of the measure of effectiveness of signalized intersections. The exploratory work done by two of the writers of this paper using images created by the animation feature of CORSIM traffic simulation software indicated that such application can actually produce stopped delay estimates commensurate with the results of the Institute of Transportation Engineers (ITE) method. However, CORSIM simulation images do not have parallax problems, and vehicle color and size and pavement color were practically the same for the entire evaluation field. The three methods (gap, gap-hybrid, and motion) developed in this study are able to overcome these problems associated with actual traffic flow images at an acceptable level. The methods were tested with two image data sets taken at two different locations with different camera angles. The performance of the three methods varies depending on the quality of image, camera angle, and calibrated parameter values used for each method, but in both cases they were able to produce average stopped delays similar to those estimated by the ITE manual method. At present the software that executes the three methods allows the user to analyze one approach lane at a time using digitized still images taken from analog video films; however, the software can be expanded to analyze multiple approach lanes and digital images dynamically fed by digital traffic monitoring cameras. With this automated procedure the traffic engineer can estimate average stopped delays in his or her office, greatly saving time, money, and the manpower necessary for conducting field data collections.
Three-dimensional-object recognition by use of single-exposure on-axis digital holography (2005)

On-axis phase-shifting digital holography requires recording of multiple holograms. We describe a novel real-time three-dimensional- (3-D-) object recognition system that uses single-exposure on-axis digital holography. In contrast to 3-D-object recognition by means of a conventional phase-shifting scheme that requires multiple exposures, our proposed method requires only a single digital hologram to be synthesized and used to recognize 3-D objects. A benefit of the proposed 3-D recognition method is enhanced practicality of digital holography for 3-D recognition in terms of its simplicity and greater robustness to external scene parameters such as moving targets and environmental noise factors. We show experimentally the utility of the single-exposure on-axis digital holography-based 3-D-object recognition method.
ChemInform Abstract: Germanium‐Modified Cordierite Ceramics with Low Thermal Expansion. (1987)

Abstract The preparation of highly dense, single‐phase Ge‐modified cordierite is described.
Formant estimation for speech recognition (1998)

This paper presents a new method for estimating formant frequencies. The formant model is based on a digital resonator. Each resonator represents a segment of the short-time power spectrum. The complete spectrum is modeled by a set of digital resonators connected in parallel. An algorithm based on dynamic programming produces both the model parameters and the segment boundaries that optimally match the spectrum. We used this method in experimental tests that were carried out on the TI digit string data base. The main results of the experimental tests are: (1) the presented approach produces reliable estimates of formant frequencies across a wide range of sounds and speakers; and (2) the estimated formant frequencies were used in a number of variants for recognition. The best set-up resulted in a string error rate of 4.2% on the adult corpus of the TI digit string data base.
Improved hydrophone calibration by combining acoustic holography with the radiation force balance measurements (2013)

Ultrasound sources are frequently characterized by the radiation force (RF) balance method that is based on the relation between the total acoustic power and RF on absorbing or reflecting targets. This relation is usually taken from the plane-wave approximation or with a geometrical correction for focused sources. However, real sources emit inhomogeneous acoustic beams. Acoustic holography is a method of recording the true field by measuring both pressure magnitude and phase over a 2D surface (a hologram). The hologram makes it possible to accurately calculate the radiation stress tensor on the surface of the absorbing target. Such measurements allow the relation of hydrophone sensitivity with measured RF based on the known exact expression for RF as a function of the 2D pattern of acoustic pressure and particle velocity. This suggests an improved approach for single-frequency hydrophone calibration that benefits from the inherent accuracy of mass balances as well as the fact that pressure approximately scales with one half of the accuracy of the RF measurement. In the current study this approach was used to calibrate a hydrophone by characterizing a 1-MHz flat piezoceramic source in water using acoustic holography and a RF balance. [Work supported by RFBR and NIH EB007643.]
Antigen‐Specific Cancer Immunotherapy: HPV‐Associated Cervical Cancer as a Model System (2007)

This chapter contains sections titled: Introduction Strategies to Enhance DNA Vaccine Potency Summary and Conclusions Acknowledgments References
Pressurized fuel cell power plant with steam flow through the cells. [using waste heat to compress air and fuel] (1976)

A fuel cell power plant for producing electricity uses pressurized air and fuel in the cells. The air is compressed by compressor apparatus powered by waste energy in the form of hot pressurized gases including hot pressurized steam produced by the power plant. In one embodiment the compressor apparatus includes a turbine operably connected to a compressor, and hot pressurized gases produced by the power plant flow into the turbine thereby driving the compressor. The steam is generated by heat from the fuel cells, passes through the fuel cells adjacent the cathode electrode thereof, and is delivered into the turbine along with the other gases.