gebhart/patrepeval huggingface dataset:
Elevate: A Walkable Pin-Array for Large Shape-Changing Terrains (2021)

Current head-mounted displays enable users to explore virtual worlds by simply walking through them (i.e., real-walking VR). This led researchers to create haptic displays that can also simulate different types of elevation shapes. However, existing shape-changing floors are limited by their tabletop scale or the coarse resolution of the terrains they can display due to the limited number of actuators and low vertical resolution. To tackle this challenge, we introduce Elevate, a dynamic and walkable pin-array floor on which users can experience not only large variations in shapes but also the details of the underlying terrain. Our system achieves this by packing 1200 pins arranged on a 1.80 × 0.60m platform, in which each pin can be actuated to one of ten height levels (resolution: 15mm/level). To demonstrate its applicability, we present our haptic floor combined with four walkable applications and a user study that reported increased realism and enjoyment.
Pengaruh Kualitas Pelayanan dan Harga terhadap Kepuasan Pelanggan pada Expedisi di Pekanbaru (Studi PT. Jne (Jalur Nugraha Ekakurir) Pekanbaru) (2017)

Problems hearts Research singer is whether the quality of service and price effect Satisfaction of customers, as for the purpose Of Research Singer is to review determine the effect of service quality and price of Satisfaction of customers (Study PT. JNE (JNE) Pekanbaru. quality service and price as a variable (X1, X2) meanwhile customer satisfaction as the dependent variable (Y).The problem in this research is the number of customers who experienced fluctuations in Pekanbaru JNE, and in the last 4 years are not achieving the target of only acquired in 2013. The research sample taken as many as 93 respondents from the population is calculated using the formula slovin. Data obtained from the questionnaire and subsequently processed to then be tested with statistics through SPSS.From the results of tests carried out showed that the quality of service and price positive and significant impact on customer satisfaction at PT. JNE (Line NugrahaEkakurir) Pekanbaru. Data analysis method used is multiple linear regression analysis and partial regression analysis.
Wireless sensor network based e-health system - implementation and experimental results (2010)

With the increasing number senior citizens, E-health is targeted for home use with the special requirements of being usable in everyday life and low cost. A wireless sensor network application is proposed here for 24 hour constant monitoring without disturbing daily activities of elderly people and their caretakers. In the system proposed, both fixed and body (mobile) sensors are used. Since not every elder likes to have a sensor board attached to him/her, and in many cases, he/she may not carry the sensor; the home sensor network independently would have the ability to monitor the health status and living environment based on the multisensor data analysis and fusion. A mixed positioning algorithm is proposed to determine where the elderly person is. The purpose of the positioning is to help the system to determine the person's activities and further to make decisions about his/her health status. The system could take care of two types of the basic needs of an elderly person: everyday needs as abnormal events and emergency alarms to doctors and caretakers through telephone, SMS and e-mail, and day to day requirements such as taking of medicine, having lunch, turn off the microwave oven, and so on. At same time, the system is sensitive to security and privacy issues.
Photocatalytic C–F alkylation; facile access to multifluorinated arenes (2015)

C-F functionalizations that provide C-C bonds are challenging synthetic transformations, due in part to the large C-F bond strength, short bond length, nonpolarizable nature, the production of fluoride, and the regioselectivity-in the case of multifluorinated substrates. However, commercially available highly fluorinated arenes possess great synthetic potential because they already possess the C-F bonds in the desired locations that would be difficult to selectively fluorinate. In order to take advantage of this potential, selective C-F functionalizations must be developed. Herein, we disclose conditions for the photocatalytic reductive alkylation of highly fluorinated arenes with ubiquitous and unactivated alkenes. The mild reaction conditions provide for a broad functional group scope, and the reaction is remarkably efficient using just 0.25 mol% catalyst. Finally, we demonstrate the utility of the strategy by converting highly fluorinated arenes to elaborate (hetero)arenes that contain 2-5 C<sub>aryl</sub>-F bonds <i>via</i> synergistic use of photocatalysis and S<sub>N</sub>Ar chemistry.
The importance of chain connectivity in the formation of non-covalent interactions between polymers and single-walled carbon nanotubes and its impact on dispersion (2010)

In this study we investigate the formation of non-covalent electron donor–acceptor (EDA) interactions between polymers and single-walled carbon nanotubes (SWNTs) with the goal of optimizing interfacial adhesion and homogeneity of nanocomposites without modifying the SWNT native surface. Nanocomposites of SWNTs and three sets of polymer matrices with varying composition of electron donating 2-(dimethylamino)ethyl methacrylate (DMAEMA) or electron accepting acrylonitrile (AN) and cyanostyrene (CNSt) were prepared, quantitatively characterized by optical microscopy and Raman spectroscopy (Raman mapping, Raman D* peak shifts) and qualitatively compared through thick film composite visualization. The experimental data show that copolymers with 30 mol% DMAEMA, 45 mol% AN, 23 mol% CNSt and polyacrylonitrile homopolymer have the highest extent of intermolecular interaction, which translates to an optimum SWNT spatial dispersion among the series. These results are found to correlate very well with the intermolecular interaction energies obtained from quantum density functional theory calculations. Both experimental and computational results also illustrate that chain connectivity is critical in controlling the accessibility of the functional groups to form intermolecular interactions. This means that an adequate distance between interacting functional groups on a polymer chain is needed in order to allow efficient intermolecular contact. Thus, controlling the amount of electron donating or withdrawing moieties throughout the polymer chain will direct the extent of EDA interaction, which enables tuning the SWNT dispersion.
Mildly elevated liver transaminase levels in the asymptomatic patient. (2005)

Mild elevations in liver chemistry tests such as alanine transaminase and aspartate transaminase can reveal serious underlying conditions or have transient and benign etiologies. Potential causes of liver transaminase elevations include viral hepatitis, alcohol use, medication use, steatosis or steatohepatitis, and cirrhosis. The history should be thorough, with special attention given to the use of medications, vitamins, herbs, drugs, and alcohol; family history; and any history of blood-product transfusions. Other common health conditions, such as diabetes, heart disease, and thyroid disease, can cause or augment liver transaminase elevations. The recent American Gastroenterological Association guideline regarding the evaluation and management of abnormal liver chemistry tests proposes a practical, algorithmic approach when the history and physical examination do not reveal the cause. In addition to liver chemistries, an initial serologic evaluation includes a prothrombin time; albumin; complete blood count with platelets; hepatitis A, B, and C serologies; and iron studies. Depending on the etiology, management strategies may include cessation of alcohol use, attention to medications, control of diabetes, and modification of lifestyle factors such as obesity. If elevations persist after an appropriate period of observation, further testing may include ultrasonography and other serum studies. In some cases, biopsy may be indicated.
Non-doped thermally activated delayed fluorescent organic light-emitting diodes using an intra- and intermolecular exciplex system with a <i>meta</i>-linked acridine–triazine conjugate (2018)

We report new TADF molecules (AmT and AmmT) for highly efficient non-doped OLEDs utilizing intra- and intermolecular charge transfer excitons.
Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo (2015)

Selective inhibitors of the protein tyrosine phosphatase SHP2 (src homology region 2 domain phosphatase; PTPN11), an enzyme that is deregulated in numerous human tumors, were generated through a combination of chemical synthesis and structure-based rational design. Seventy pyridazolon-4-ylidenehydrazinyl benzenesulfonates were prepared and evaluated in enzyme assays. The binding modes of active inhibitors were simulated in silico using a newly generated crystal structure of SHP2. The most powerful compound, GS-493 (4-{(2Z)-2-[1,3-bis(4-nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden]hydrazino}benzenesulfonic acid; 25) inhibited SHP2 with an IC50 value of 71±15 nM in the enzyme assay and was 29- and 45-fold more active toward SHP2 than against related SHP1 and PTP1B. In cell culture experiments compound 25 was found to block hepatocyte growth factor (HGF)-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells, as indicated by a decrease in the minimum neighbor distances of cells. Moreover, 25 inhibited cell colony formation in the non-small-cell lung cancer cell line LXFA 526L in soft agar. Finally, 25 was observed to inhibit tumor growth in a murine xenograft model. Therefore, the novel specific compound 25 strengthens the hypothesis that SHP2 is a relevant protein target for the inhibition of mobility and invasiveness of cancer cells.
Overlapping peptide-binding specificities of HLA-B27 and B39: Evidence for a role of peptide supermotif in the pathogenesis of spondylarthropathies (1999)

A subset of natural HLA-B27 ligands was capable of binding to B*3901. In addition to Arg at position 2 (Arg2), hydrophobic/aromatic C-terminal residues, such as Leu or Phe, seemed to be crucial for the cross-specificity. These results suggested that HLA-B27 and B39 recognize overlapping peptide repertoires, supporting the hypothesis that the peptides presented by both of these class I antigens play a role in the pathogenesis of SpA.
Reduced Tetracycline Bioavailability Caused by Magnesium Aluminum Silicate in Liquid Formulations of Bismuth Subsalicylate (1997)

In vitro and in vivo data from this study indicate that Veegum, a suspending agent, and not the active agent bismuth subsalicylate, is the primary ingredient in liquid formulations of bismuth subsalicylate responsible for a decrease in tetracycline bioavailability. In addition, the mechanism of interaction is not likely due to complexation between tetracycline and bismuth subsalicylate, as previously postulated, but rather is caused by adsorption of tetracycline to the excipient Veegum, which is present only in the liquid formulation of bismuth subsalicylate. The clinical relevance of this interaction has not been determined.
Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration (2012)

Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.
Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−Desulfurization Chemistry (2014)

Native chemical ligation followed by desulfurization is a powerful strategy for the assembly of proteins. Here we describe the development of a high-yielding, one-pot ligation−desulfurization protocol that uses trifluoroethanethiol (TFET) as a novel thiol additive. The synthetic utility of this TFET-enabled methodology is demonstrated by the efficient multi-step one-pot syntheses of two tick-derived proteins, chimadanin and madanin-1, without the need for any intermediary purification.
Biological control of <i>Botrytis</i> stem infection of greenhouse tomatoes (1996)

Botrytis cinerea infects stem wounds of greenhouse tomatoes and can cause serious economic losses. A bioassay using stem sections was developed to study wound infection and to screen potential fungal antagonists for activity against Botrytis Cladosporium cladosporioides reduced infection from 80–100% to 0–10%. A much smaller proportion of Trichoderma harzianum gave this reduction. Similar results were obtained on whole plants. Penicillium isolates varied widely in activity. The concentration of Cladosporium and Trichoderma which gave the highest level of protection was c . 10 8 cfu/mL. When only half the wound was treated, simulating poor spray coverage, Cladosporium isolates still prevented infection. By contrast, Trichoderma isolates and four fungicides failed to give the same level of protection. The ability of certain fungal isolates to colonize the wound surface was thought to be partly responsible for this activity. The successful application of antagonists to whole plants using both aqueous suspensions and gel secateurs is described.
An Algorithm for Limited Capacity Inventory Problem with Staggering (1983)

This paper describes an algorithm for solving the integer programming problem, which arises in the staggering approach to limited capacity inventory systems. Numerical examples are given.
Simultaneous observation of phase-stepped images for automated photoelasticity (1998)

A novel instrument is described for the simultaneous observation and capture of four phase-stepped photoelastic images. A theoretical description of the optics of the instrument is presented for the first time. Three examples are given of the use of the instrument in reflection photoelasticity to generate full-field maps of isochromatic and isoclinic parameters. The results from these experiments show close correlation to results from both theoretical analyses and manual measurements. The instrument can be used in either reflection or transmission mode and it is concluded that the new instrument significantly enhances the potential for real-time studies using reflection photoelasticity.
Tropical Medicine and Health in the Developing World (1988)

Let me begin by telling you that it has been a privilege to be entrusted with the affairs of the Society for these 12 months, so much so that I leave it with regret. It was my feeling at the time of Harry Hoogstraal's death, before he could serve as your president, that Franz von Lichtenberg should serve for 2 years and thereby begin a new policy of 2-year terms. The Council rejected this option and I am honored by their having selected me. Even as the only nonelected president in the Society's history—that is, as the Gerald Ford of this Society—I cannot overlook the great honor it is to be numbered among the eminent former presidents.Despite what you might think, a pleasant perquisite of the job has been the stimulus to review some of our history. Most of you who have listened to these perorations in the past know that reading past presidents' speeches is considered mandatory.
Polymorphism of HLA-C locus in a Northern Chinese Han population (2004)

To study the characteristic of HLA-C distribution of Northern Chinese people and obtain more comprehensive and accurate gene data. HLA-C and A, B typing were detected by sequence-specific primers (PCR-SSP). 14 HLA-C alleles and 24 HLA-C-B, 5 HLA-A-C haplotypes with linkage disequilibrium were found. Their gene frequency were gotten. This data may serve as normal reference values for the population in North China.
Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers (2019)

Endogenous signaling molecules derived from lipids, peptides, and DNA, are important regulators of physiological processes during pregnancy. The effect of their collective impact on preterm birth (delivery < 37 weeks gestation) is understudied. We aimed to characterize the associations and predictive capacity of an extensive panel of eicosanoids, immune biomarkers, oxidative stress markers, and growth factors towards preterm birth and its subtypes. We conducted a cross-sectional study of pregnant women (recruited < 15 weeks gestation) in the LIFECODES birth cohort, which included 58 cases of preterm birth and 115 controls that delivered term. Among the cases there were 31 cases who had a spontaneous preterm birth (cases who had spontaneous preterm labor and/or preterm premature rupture of membranes) and 25 that had preterm birth associated with aberrant placentation (cases who had preeclampsia and/or intrauterine growth restriction) and 2 cases that could not be sufficiently categorized as either. We analyzed single biomarker associations with each preterm birth outcome using multiple logistic regression. Adaptive elastic-net was implemented to perform a penalized multiple logistic regression on all biomarkers simultaneously to identify the most predictive biomarkers. We then organized biomarkers into biological groups and by enzymatic pathways and applied adaptive elastic-net and random forest to evaluate the accuracy of each group for predicting preterm birth cases. The majority of associations we observed were for spontaneous preterm birth, and adaptive elastic-net identified 5-oxoeicosatetraenoic acid, resolvin D1, 5,6-epoxy-eicsatrienoic acid, and 15-deoxy-12,14-prostaglandin J2 as most predictive. Overall, lipid biomarkers performed the best at separating cases from controls compared to other biomarker categories (adaptive elastic-net AUC = 0.78 [0.62, 0.94], random forest AUC = 0.84 [0.72, 0.96]). Among the enzymatic pathways that differentiate eicosanoid metabolites, we observed the highest prediction of overall preterm birth by lipoxygenase metabolites using random forest (AUC = 0.83 [0.69, 0.96]), followed by cytochrome p450 metabolites using adaptive elastic-net (AUC = 0.74 [0.52, 0.96]). In this study we translate biological hypothesis into the language of modern machine learning. Many lipid biomarkers were highly associated with overall and spontaneous preterm birth. Among eicosanoids, lipoxygenase and cytochrome p450 products performed best in identifying overall and spontaneous preterm birth. The combination of lipid biomarkers may have good utility in clinical settings to predict preterm birth.
Melting of (Mg, Fe)SiO <sub>3</sub> -Perovskite to 625 Kilobars: Indication of a High Melting Temperature in the Lower Mantle (1993)

The melting curves of two compositions of (Mg,Fe) SiO3-perovskite, the likely dominant mineral phase in the lower mantle, have been measured in a C02 laser-heated diamond cell with direct temperature measurements and in situ detection of melting. At 625 kilobars, the melting temperature is 5000 +/- 200 kelvin, independent of composition. Extrapolation to the core-mantle boundary pressure of 1.35 megabar with three different melting relations yields melting temperatures between 7000 and 8500 kelvin. Thus, the temperature at the base of the lower mantle, accepted to lie between 2550 and 2750 kelvin, is only at about one-third of the melting temperature. The large difference between mantle temperature and corresponding melting temperature has several important implications; particularly the temperature sensitivity of the viscosity is reduced thus allowing large lateral temperature variations inferred from seismic tomographic velocity anomalies and systematics found in measured velocity-density functions. Extensive melting of the lower mantle can be ruled out throughout the history of the Earth.
<i>Cbfa2</i> is required for the formation of intra-aortic hematopoietic clusters (1999)

Cbfa2 (AML1) encodes the DNA-binding subunit of a transcription factor in the small family of core-binding factors (CBFs). Cbfa2 is required for the differentiation of all definitive hematopoietic cells, but not for primitive erythropoiesis. Here we show that Cbfa2 is expressed in definitive hematopoietic progenitor cells, and in endothelial cells in sites from which these hematopoietic cells are thought to emerge. Endothelial cells expressing Cbfa2 are in the yolk sac, the vitelline and umbilical arteries, and in the ventral aspect of the dorsal aorta in the aorta/genital ridge/mesonephros (AGM) region. Endothelial cells lining the dorsal aspect of the aorta, and elsewhere in the embryo, do not express Cbfa2. Cbfa2 appears to be required for maintenance of Cbfa2 expression in the endothelium, and for the formation of intra-aortic hematopoietic clusters from the endothelium.
Sagnac fiber-ring interferometer gyro with electronic phase sensing using a (GaAl)As laser (1978)

Rotation-sensitive fiber-ring interferometers have been demonstrated using balanced heterodyne phase-detection techniques. Red He/Ne and infrared (GaAl)As lasers were employed with balanced elasto-optic frequency shifters as sources. Rotation-induced phase shift (Sagnac effect) was demonstrated using both single-mode and multimode low-loss fibers.
Survivorship of unconstrained total shoulder arthroplasty. (1989)

The results of fifty-three unconstrained (Neer-II or Gristina) total shoulder arthroplasties were reviewed with the use of survivorship analysis. Failure was defined as the need for revision or the onset of the patient's dissatisfaction. The method of survivorship analysis is presented in detail. Fifty-one total shoulder arthroplasties were followed for a minimum of two years (average, sixty-seven months). The results are reported with the use of the American Shoulder and Elbow Surgeons' rating form. After eleven years, the survivorship was 73 per cent for all prostheses, 71 per cent for the Neer prostheses, and 92 per cent for all prostheses in patients who had rheumatoid arthritis. Data on survivorship of the Gristina prosthesis were available after four years only, at which time it was 100 per cent. The relief of pain, which was the primary reason for the operation, was good or excellent in 82 per cent, improved in 6 per cent, and poor in 12 per cent of the shoulders in these patients.
Cytostatic treatment of metastatic cervical carcinoma. (1989)

The activity of cytostatics in cervical cancer has not as yet been sufficiently investigated. This is especially true for combined cytostatic treatments. The only two cytostatics that have been adequately examined in clinical trials in a larger number of patients are 5-fluorouracil and cis-dichlorodiamineplatinum. The paper presents the results of treatment with single cytostatic agents and the combinations of different cytostatics, emphasizing the role of combined treatment using irradiation and cytostatics. It also describes the preliminary results of a Phase II trial going on at the Central Institute for Tumors in Zagreb, using a combination of cis-DDP, 5-fluorouracil and vincristine. So far the results of 11 out of 14 patients included in the trial have been evaluated. Objective remission (CR + PR) was achieved in 4 patients (33%). Toxic side-effects were mild and tolerable for the patients. In conclusion, the reasons are given why chemotherapy has not as yet gained a more important place in the treatment of advanced forms of cervical cancer.