gebhart/patrepeval huggingface dataset:
Evidence for Fusion Between Cardiac and Skeletal Muscle Cells (2004)

Cardiomyoplasty with skeletal myoblasts may benefit cardiac function after infarction. Recent reports indicate that adult stem cells can fuse with other cell types. Because myoblasts are "fusigenic" cells by nature, we hypothesized they might be particularly likely to fuse with cardiomyocytes. To test this, neonatal rat cardiomyocytes labeled with LacZ and green fluorescent protein (GFP) were cocultured with unlabeled C2C12 myoblasts. After 3 days, we observed a small population of skeletal myotubes that expressed LacZ and GFP, indicating cell fusion. To test whether such fusion occurred in vivo, LacZ-expressing C2C12 myoblasts were grafted into normal nude mouse hearts. At 2 weeks after grafting, cells at the graft-host interface expressed both LacZ and cardiac-specific myosin light chain 2v (MLC2v). To test more definitively whether fusion between skeletal and cardiac muscle could occur, we used a Cre/lox reporter system that activated LacZ only upon cell fusion. When neonatal cardiomyocytes from -myosin heavy chain promoter (-MHC)-Cre mice were cocultured with myoblasts from floxed-lacZ reporter mice, LacZ was activated in a subset of cells, indicating cell fusion occurred in vitro. Finally, we grafted the floxed-lacZ myoblasts into normal hearts of -MHC-Cre+ and -MHC-Cre- mice (n=5 each). Hearts analyzed at 4 days and 1 week after transplantation demonstrated activation of LacZ when the skeletal muscle cells were implanted into hearts of -MHC-Cre+ mice, but not after implantation into -MHC-Cre- mice. These data indicate that skeletal muscle cell grafting gives rise to a subpopulation of skeletal-cardiac hybrid cells with a currently unknown phenotype. The full text of this article is available online at http://circres.ahajournals.org.
Analysis of Multipath Mitigation Techniques with Land Mobile Satellite Channel Model (2012)

Multipath is undesirable for Global Navigation Satellite System (GNSS) receivers, since the reception of multipath can create a significant distortion to the shape of the correlation function leading to an error in the receivers’ position estimate. Many multipath mitigation techniques exist in the literature to deal with the multipath propagation problem in the context of GNSS. The multipath studies in the literature are often based on optimistic assumptions, for example, assuming a static two-path channel or a fading channel with a Rayleigh or a Nakagami distribution. But, in reality, there are a lot of channel modeling issues, for example, satellite-to-user geometry, variable number of paths, variable path delays and gains, Non Line-Of-Sight (NLOS) path condition, receiver movements, etc. that are kept out of consideration when analyzing the performance of these techniques. Therefore, this is of utmost importance to analyze the performance of different multipath mitigation techniques in some realistic measurement-based channel models, for example, the Land Mobile Satellite (LMS) channel model [1]-[4], developed at the German Aerospace Center (DLR). The DLR LMS channel model is widely used for simulating the positioning accuracy of mobile satellite navigation receivers in urban outdoor scenarios. The main objective of this paper is to present a comprehensive analysis of some of the most promising techniques with the DLR LMS channel model in varying multipath scenarios. Four multipath mitigation techniques are chosen herein for performance comparison, namely, the narrow Early-Minus-Late (nEML), the High Resolution Correlator, the C/N0-based two stage delay tracking technique, and the Reduced Search Space Maximum Likelihood (RSSML) delay estimator. The first two techniques are the most popular and traditional ones used in nowadays GNSS receivers, whereas the later two techniques are comparatively new and are advanced techniques, recently proposed by the authors. In addition, the implementation of the RSSML is optimized here for a narrow-bandwidth receiver configuration in the sense that it now requires a significantly less number of correlators and memory than its original implementation. The simulation results show that the reduced-complexity RSSML achieves the best multipath mitigation performance in moderate-to-good carrier-to-noise density ratio with the DLR LMS channel model in varying multipath scenarios.
A 0.18&#x00B5;m CMOS narrow-band LNA linearization using digital base-band post-distortion (2010)

In this paper, a novel digital base-band post-distorter is proposed to compensate for nonlinearities in low noise amplifiers. Though high gain, good input matching and low noise (low noise figure) are important factors, linearity and low power combined with these factors is most desirable. The proposed post-distorter achieves these factors by an indirect learning architecture at base-band to compensate for nonlinearities. The low noise amplifier was designed in the standard 0.18 μm CMOS technology. It achieved a 8dB improvement in linearity with respect to the input power.
Two RFLPs at the human renin (ren) gene locus (1986)

5 kb full length human renin cDNA isolated from a kidney cDNA library and subeloned into pUC 9
Directed lysis of experimental cancer by<i>β</i>‐carotene in liposomes (1991)

The purpose of this study was to extend the knowledge of the antitumor activity of liposomes and to identify, for the first time, the antitumor effect of liposomes with the antioxidant beta-carotene. The administration of the carotenoid encapsulated in in liposomes has the advantages of quantitation, facilitation, and most importantly an increased therapeutic response, resulting in the accentuation of regression of carcinoma in the hamster pouch. Tumors induced after the application of the carcinogen 7,12-dimethylbenz[alpha]anthracene (0.5%) were injected with liposomes composed of phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine in a ratio of 1:1:1 (large unilamellar vesicles). Tumor-bearing animals were divided into four groups, each containing 10 hamsters. The group treated with the liposomes of beta-carotene exhibited a significantly lower tumor burden (approx 5,000-fold difference) than the control tumor group. Electron- and light-micrographic analyses were used to substantiate the gross observations of tumor regression. It was noted that the carcinoma cells endocytozed liposomes in increased numbers compared with normal mucosa treated with liposomes. In addition, non-tumor-bearing hamsters injected with beta-carotene liposomes or liposomes alone did not exhibit any pathological change to the normal mucosa. An inflammatory infiltrate consisting of mononuclear cells, mast cells, and some polymorphonuclear leukocytes was noted, and degranulating polymorphonuclear leukocytes and mast cells and eosinophils predominated in the tumor controls (7,12-dimethylbenz[alpha]anthracene treated only). Notably, not all areas of degenerating dysplasia or early carcinoma exhibited a dense inflammatory response adjacent to the mucosa after the injection of beta-carotene liposomes. The results demonstrate a selective nontoxic therapy to regress experimental oral cancer.
Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis (2018)

Pancreatic cancer is one of the most lethal types of cancer with a mortality rate of almost 95%. Treatment with current chemotherapeutic drugs has limited success due to poor responses. Therefore, the development of novel drugs or effective combination therapies is urgently required. Piperlongumine (PL) is a natural product with cytotoxic properties restricted to cancer cells by significantly increasing intracellular reactive oxygen species (ROS) levels. In the present study, we demonstrated that PL induced cancer cell death through, at least in part, the induction of ferroptosis, as the cancer cell-killing activity was inhibited by the antioxidant, N‑acetylcysteine, ferroptosis inhibitors (ferrostatin‑1 and liproxstatin‑1) and the iron chelator, deferoxamine (DFO), but not by the apoptosis inhibitor, Z-VAD-FMK, or the necrosis inhibitor, necrostatin‑1. Cotylenin A (CN‑A; a plant growth regulator) exhibits potent antitumor activities in several cancer cell lines, including pancreatic cancer cell lines. We found that CN‑A and PL synergistically induced the death of pancreatic cancer MIAPaCa‑2 and PANC‑1 cells for 16 h. CN‑A enhanced the induction of ROS by PL for 4 h. The synergistic induction of cell death was also abrogated by the ferroptosis inhibitors and DFO. The present results revealed that clinically approved sulfasalazine (SSZ), a ferroptosis inducer, enhanced the death of pancreatic cancer cells induced by PL and the combined effects were abrogated by the ferroptosis inhibitors and DFO. SSZ further enhanced the cancer cell-killing activities induced by combined treatment with PL plus CN‑A. On the other hand, the synergistic induction of cell death by PL and CN‑A was not observed in mouse embryonic fibroblasts (MEFs), and SSZ did not enhance the death of MEFs induced by PL plus CN‑A. These results suggest that the triple combined treatment with PL, CN‑A and SSZ is highly effective against pancreatic cancer.
Minder bespuitingen nodig : strijd tegen zwartvruchtrot een stap verder (2010)

De bestrijding van zwartvruchtrot is een stap verder. Uit onderzoek van PPO Fruit kwam naar voren dat er met het Stemphy-waarschuwingsmodel minder bespuitingen nodig zijn om hetzelfde effect te krijgen te krijgen als bij wekelijkse behandelingen. Een model dat droogtestress aangaf, bestreed ook zwartvruchtrot, maar was minder effectief
Growth Responses, Ion Relations, and Osmotic Adaptations of Eleven C<sub>4</sub> Turfgrasses to Salinity (1990)

Abstract Shortages of fresh water, coupled with soil salinization in many areas have resulted in an increased need for salt tolerant turfgrasses. This study was conducted to compare growth and physiological responses of eleven C 4 (grasses which utilize the C‐4 carboxylic acid pathway in photosynthesis) turfgrasses to salinity. Grasses were grown in solution culture in a glasshouse, with NaCl added to achieve salinities of 0.7, 10, 20, and 30 dS m −1 (0, 99, 198, and 298 m M NaCl). Grasses were ranked for salinity tolerance according to their relative top growth reductions with increasing salinity. Tolerant grasses included a Hawaii selection of seashore paspalum ( Paspalum vaginatum Swartz), two St. Augustinegrasses ( Stenotaphrum secondtum Walt.), and manilagrass ( Zoysia matrella L.). Bermudagrasses ( Cynodon spp. (L.) Pers. Burtt‐Davey) tested were generally less tolerant to salinity. Shoot and root Na and CI concentrations reached very high levels in St. Augustinegrasses, and were relatively high in seashore paspalum and Japanese lawngrass ( Zoysia japonica Steud.). In contrast, manilagrass and bermudagrasses maintained low levels of Na and Cl under high salinity which is indicative of ion regulation, due in part to efficient leaf salt glands. Seashore paspalum maintained higher shoot and root K concentrations under high salinity than did other grasses. All grasses adjusted osmotically under increasing salinity. Although St. Augustinegrasses and seashore paspalum accumulated Na and Cl in the shoots to relatively high levels, they maintained much higher tissue water levels than did other grasses, resulting in intermediate sap osmolalities.
Proposal for a new resonance adjustment method in magnetically coupled resonance type wireless power transmission (2012)

In a magnetically coupled resonance system which enables intermediate-range power transmission, over 100 high Q is required in the power transmission resonance circuit. In other words, high-precision adjustment of the resonance frequency is necessary. In this paper, we are proposing a pure-electronic resonance frequency adjustment circuit which does not require any complicated controls. With this proposal, the resonant condition can be maintained without using high-precision parts or mechanical adjustment mechanisms.
Novel Area-Efficient FPGA Architectures for FIR Filtering With Symmetric Signal Extension (2009)

This paper presents four novel area-efficient field-programmable gate-array (FPGA) bit-parallel architectures of finite impulse response (FIR) filters that smartly support the technique of symmetric signal extension while processing finite length signals at their boundaries. The key to this is a clever use of variable-depth shift registers which are efficiently implemented in Xilinx FPGAs in the form of shift register logic (SRL) components. Comparisons with the conventional architecture of FIR filter with symmetric boundary processing show considerable area saving especially with long-tap filters. For instance, our architecture implementation of the 8-tap low Daubechies-8 FIR filter achieves ~ 30% reduction in the area requirement (in terms of slices) compared to the conventional architecture while maintaining the same throughput. Two of the above-cited novel architectures are dedicated to the special case of symmetric FIR filters. The first architecture is highly area-efficient but requires a clock frequency doubler. While this reduces the overall processing speed (to a maximum of 2), it does maintain a high throughput. Moreover, this speed penalty is cancelled in bi-phase filters which are widely used in multirate architectures (e.g., wavelets). Our second symmetric FIR filter architecture saves less logic than the first architecture (e.g., 10% with the 9-tap low Biorthogonal 9&7 symmetric filter instead of 37% with the first architecture) but overcomes its speed penalty as it matches the throughput of the conventional architecture.
Synthesis, antihelmintic and insilico evaluation of 5-(substituted styryl)-5- (benzylideneamino)-1, 2, 4-triazolidine-3-ones (2015)

A series of 5-(substitutedstyryl)-5-(benzylideneamino) - 1, 2, 4-triazolidine-3-one derivatives were synthesized by condensation of oxazol-5-ones by reaction of hippuric acid and different aldehydes with semicarbazide. Structures of the compounds were characterized on the basis of IR, 13CNMR and 1H NMR. Compounds 1b-12b were screened for antihelmintic activity .Test results revealed that compound 7b and 11b showed paralysis time of 3.3 and 3.1 min and death time of 4.1 and 4.5 min while the standard drug albendazole showed paralysis time of 11 min and death time of 21min, respectively, at the same concentration of 50mg/ml. All compounds were found to posses both vermifuge and vermicide properties.
Bandwidth-Efficient Packet Scheduling for Live Streaming With Network Coding (2016)

Network coding (NC) brings substantial improvements in terms of throughput and delay in collaborative media streaming applications. A key aspect of NC-driven live peer-to-peer streaming is the packet scheduling policy. Indeed, lack of synchronization among peers usually results in significantly redundant packet transmission, which in turn leads to severe bandwidth inefficiencies. In this paper, we address the problem of finding a suitable asynchronous packet scheduling policy that greatly helps to overcome this critical redundant transmission problem. We propose a bandwidth cost minimization technique under a full video packet recovery constraint. In order to add scalability and improved performance, we also further derive a distributed packet scheduling algorithm. Both implementation and analytical considerations of the proposed approaches are described in this paper. Experimental results confirm that the proposed algorithms deliver higher bandwidth efficiency with reduced redundancy and communication overhead rate and, consequently, better quality-of-service in terms of improved video quality and delivery ratio.
Lithographic evaluation and chemical modeling of acid amplifiers used in EUV photoresists (2009)

This paper describes the lithographic properties of fifteen acid amplifiers (AAs) and the chemical modeling approach used to predict their thermal stability in an ESCAP polymer resist system at 70 and 110 °C. Specifically, we show how added AAs affect the sensitivity (Eo and Esize), resolution, line edge roughness (LER), exposure latitude, and Z-parameter of ESCAP resists. We find that acid amplifiers that generate fluorinated sulfonic acids give the best combination of sensitivity, LER, and exposure latitude. Additionally, we show that these compounds are not photochemically active. Combining thermodynamic and kinetic modeling has allowed us to predict the relative enthalpies of activation for catalyzed and uncatalyzed decomposition pathways and compare the results to experimental thermal stability tests.
How Moats Protect Superconductor Films From Flux Trapping (2016)

Trapping of residual magnetic field degrades the performance and, in extreme cases, destroys operability of superconductor digital circuits. It is known that moats or narrow cuts made in superconductor thin films are able to “immunize” them from flux trapping. So far, an intuition rather than science has played a more significant role in the selection of geometry and density of these moats. We formalized an estimation of the moat efficiency. This procedure involves the calculation of Gibbs potentials of arbitrary shaped films in a magnetic field and comparison of the potentials with and without vortices in the film and magnetic flux frozen in the moats. We numerically simulate evolutions of the Gibbs potentials of films slowly cooled in a constant residual magnetic field. The simulations allow forecasting equilibrium distributions of vortices and fluxes trapped in the moats corresponding to the lowest potentials. The superconductor film becomes immune to the trapping Pearl vortices if the lowest Gibbs potential can be achieved without such Pearl vortices.
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL (2015)

RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules. Whether and how RIPK3 might drive inflammation in a manner independent of MLKL and cell lysis remains unclear. Here we show that following LPS treatment, or LPS-induced necroptosis, the TLR adaptor protein TRIF and inhibitor of apoptosis proteins (IAPs: X-linked IAP, cellular IAP1 and IAP2) regulate RIPK3 and MLKL ubiquitylation. Hence, when IAPs are absent, LPS triggers RIPK3 to activate caspase-8, promoting apoptosis and NLRP3-caspase-1 activation, independent of RIPK3 kinase activity and MLKL. In contrast, in the absence of both IAPs and caspase-8, RIPK3 kinase activity and MLKL are essential for TLR-induced NLRP3 activation. Consistent with in vitro experiments, interleukin-1 (IL-1)-dependent autoantibody-mediated arthritis is exacerbated in mice lacking IAPs, and is reduced by deletion of RIPK3, but not MLKL. Therefore RIPK3 can promote NLRP3 inflammasome and IL-1β inflammatory responses independent of MLKL and necroptotic cell death.
The molecular evolutionary dynamics of oxidative phosphorylation (OXPHOS) genes in Hymenoptera (2017)

Our results showed that nuclear OXPHOS genes in Hymenoptera are evolving faster than the genes in other three insect orders. The branch test suggested that while some nuclear OXPHOS genes in Hymenoptera show a signature of positive selection, the pattern is not consistent across all nuclear OXPHOS genes. As only few codon sites were under positive selection, we suggested that positive selection might not be the only factor contributing to the rapid evolution of nuclear OXPHOS genes in Hymenoptera.
Beta-blockers and Their Effects on Protein Metabolism and Resting Energy Expenditure (1995)

In summary, beta-adrenergic receptor blocking medications have numerous metabolic side effects. Recent evidence indicates that this class of drug acutely decreases whole-body metabolic rate and increases protein oxidation in the resting human. The result of this metabolic perturbation may be a deleterious change in body composition and perhaps a creeping increase in body weight, if no subsequent alterations are made in food consumption or activity patterns. Research indicates that long-term treatment with beta-blockade may increase body fat and decrease the fat-free tissue content of the organism. Exercise is known to favorably affect body composition by decreasing percent body fat, while increasing the fat-free body tissue. Beginning a regular, moderate exercise program may help ameliorate these deleterious nutritional side effects of long-term beta-blocker therapy. Additionally, the recommendation to engage in a moderate exercise program is further indicated because of the underlying cardiovascular pathophysiology that originally required long-term beta-adrenergic treatment.
C 1<i>s</i>excitation studies of diamond (111). I. Surface core levels (1986)

By comparing the C 1s photoemission intensities from a clean diamond (111) surface to those obtained from a fluorine-covered surface, we conclude that a single (111) layer of atoms participates in the diamond 2\ifmmode\times\else\texttimes\fi{}1 surface reconstruction. The data interpretation presented does not rely on assuming an electron mean free path, but, in fact provides an independent measurement of its value. For clean diamond (111) a surface core-level peak is observed at 0.80\ifmmode\pm\else\textpm\fi{}0.05 eV lower binding energy than the bulk-C 1s peak at 285.0 eV below ${E}_{F}$. After fluorine exposure a single chemically shifted carbon peak is observed at 1.85\ifmmode\pm\else\textpm\fi{}0.05 eV higher binding energy than the bulk peak, indicating the presence of CF units at the surface.
Caveolin-1 and Breast Cancer (2007)

Caveolin is a 21-24 kD membrane protein, and it is an essential structural molecule of caveolae. So far, three members of the caveolin gene family have been cloned and identified: caveolin-1, caveolin-2 and caveolin-3. The functional roles attributed to caveolin-1 are quite diverse, ranging from cellular cholesterol transport, cell membrane composing, cellular signal transduction, cell cycle regulation and control, cell transformation to tumorigenesis. Caveolin-1 has interaction with transcription factors to regulate the expression of interrelated genes and inhibit the tumorigenesis. In addition, the caveolin-1 gene mutated in some malignant tumors, such as prostate carcinoma, tummy cancer, liver cancer, and breast cancer. Recent studies have demonstrated that caveolin-1 has close relation with breast epithelial cell transformation and breast tumor formation. This paper summarized research progress on the structural characteristic of caveolin-1, signal transduction mediated by caveolin-1 and the relationship between caveolin-1 and breast cancer.
Beware the hidden costs in managed print services : business (2010)

As companies look for ways to minimise office automation costs in the short term, Neil Rom, MD of specialist printer distributor Printacom, warns that companies need to guard against making rash decisions that could be more costly in the long run.
Biocompatible Peritoneal Dialysis: The Target Is Still Way Off (2019)

Peritoneal dialysis (PD) is a cost-effective, home-based therapy for patients with end-stage renal disease achieving similar outcome as compared to hemodialysis. Still, a minority of patients only receive PD. To a significant extend, this discrepancy is explained by major limitations regarding PD efficiency and sustainability. Due to highly unphysiological composition of PD fluids, the peritoneal membrane undergoes rapid morphological and long-term functional alterations, which limit the treatment and contribute to adverse patient outcome. This review is focused on the peritoneal membrane ultrastructure and its transformation in patients with kidney disease and chronic PD, underlying molecular mechanisms, and potential systemic sequelae. Current knowledge on the impact of conventional and second-generation PD fluids is described; novel strategies and innovative PD fluid types are discussed.