gebhart/patrepeval huggingface dataset:
Indoor pseudo-ranging of mobile devices using ultrasonic chirps (2012)

In this demonstration, we show an indoor location tracking system that broadcasts ranging data to mobile phones using ultrasonic signals. The system capitalizes on the ability for many smart-phones to detect audio above the human hearing range. This approach provides enhanced ranging capabilities to mobile devices without adding to or modifying their hardware. In [1], we describe a modulation scheme based on rate-adaptive wide-band linear frequency modulated chirp pulses that can be transmitted from standard audio tweeters at just above the human hearing frequency range. Acoustic data transmissions (even outside of the human hearing range), typically introduce audible noises (clicks) due to the non-ideal impulse response of speakers. Our scheme is optimized to avoid these artifacts by using slowly changing power-levels and gradual shifts in frequency. Each speaker simultaneously transmits a uniquely identifiably signature that can be geolocated on a map. By then applying a time-difference-of-arrival (TDOA) pseudo-ranging technique the mobile devices can localize themselves without synchronizing with the broadcasting infrastructure. This design is not only scalable with respect to the number of transmitters and tracked devices, but also improves user privacy since the mobile device can compute its position locally.
<i>Bis</i>[3‐(diethoxyphosphoryl)propyl]diallylammonium chloride: Synthesis and use of its cyclopolymer as an antiscalant (2014)

Abstract A new symmetrically substituted cationic monomer bis [3‐(diethoxyphosphoryl)propyl]diallylammonium chloride has been synthesized and cyclopolymerized to give the corresponding cationic polyelectrolyte (+) (CPE) bearing two identical (diethoxyphosphoryl)propyl penedents on the pyrrolidinium repeating units. The hydrolysis of the phosphonate ester in (+) (CPE) gave a pH‐responsive cationic polyacid (+) (CPA) bearing the motifs of a tetrabasic acid. The (+) (CPA) under pH‐induced transformation was converted into a water‐insoluble polyzwitterion acid (±) (PZA) or water‐soluble polyzwitterion/monoanion (± −) (PZMAN) or polyzwitterion/dianion (± =) (PZDAN) or polyzwitterion/trianion (± ≡) (PZTAN), all having identical degree of polymerization. The interesting solubility and viscosity behaviors of the polymers have been investigated in some detail. The apparent protonation constants of the anionic centers in (± ≡) (PZTAN) and its corresponding monomer (± ≡) (ZTAN) have been determined. Evaluation of antiscaling properties of the PZA using supersaturated solutions of CaSO 4 revealed ≈100% scale inhibition efficiency at a meager concentration of 10 ppm for a duration over 71 h at 40°C. The PZA has the potential to be an effective antiscalant in Reverse Osmosis plants. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40615.
DC-DC converter for discharging energy storage magnets (1994)

A new DC-DC converter to control the output power delivered from a magnetic energy storage magnet or an equivalent current source is discussed. The circuit consists of:(1) highly coupled transformer (air or iron core) with coupling coefficient better than 0.95; (2) low frequency mechanical or superconducting switches (0.1-10 Hz) or high frequency (10-1000 Hz) GTO switches depending on the application; (3) small voltage source (capacitor or battery) to control the output voltage. Two examples illustrating the application of this circuit are discussed. They are a step up dc current converter for use in uninterruptible power supplies and a step down one for use in discharging large current storage coil into a small current load. The efficiency expected to exceed 90 %.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A miniature fiber-optic sensor for high-resolution and high-speed temperature sensing in ocean environment (2015)

Temperature measurement is one of the key quantifies in ocean research. Temperature variations on small and large scales are key to air-sea interactions and climate change, and also regulate circulation patterns, and heat exchange. The influence from rapid temperature changes within microstructures are can have strong impacts to optical and acoustical sensor performance. In this paper, we present an optical fiber sensor for the high-resolution and high-speed temperature profiling. The developed sensor consists of a thin piece of silicon wafer which forms a Fabry-Pérot interferometer (FPI) on the end of fiber. Due to the unique properties of silicon, such as large thermal diffusivity, notable thermo-optic effects and thermal expansion coefficients of silicon, the proposed sensor exhibits excellent sensitivity and fast response to temperature variation. The small mass of the tiny probe also contributes to a fast response due to the large surface-tovolume ratio. The high reflective index at infrared wavelength range and surface flatness of silicon endow the FPI a spectrum with high visibilities, leading to a superior temperature resolution along with a new data processing method developed by us. Experimental results indicate that the fiber-optic temperature sensor can achieve a temperature resolution better than 0.001°C with a sampling frequency as high as 2 kHz. In addition, the miniature footprint of the senor provide high spatial resolutions. Using this high performance thermometer, excellent characterization of the realtime temperature profile within the flow of water turbulence has been realized.
The Liquid Crystal Properties of 4-<i>n</i>-Alkyl- and 4-<i>n</i>-Alkoxy-phenyl 4-<i>n</i>-Alkylbicyclo (2.2.2) octane-1-carboxylates (1981)

Abstract Two new series of esters incorporating the 1, 4-disubstituted bicyclo(2.2.2)octane ring system are reported. Thirty-three 4-n-alkylphenyl 4-n-alkylbicyclo(2.2.2)octane-1-carboxylates and thirty 4-n-alkoxyphenyl 4-n-alkylbicyclo(2.2.2)octane-1-carboxylates have been prepared and found to exhibit wide-range nematic phases persisting until higher temperatures than those of the corresponding esters containing either the trans-1, 4-disubstituted cyclohexane ring or the 1, 4-disubstituted benzene ring in place of the bicyclo-octane ring. Mixtures of these novel bicyclo-octane esters with cyanobiphenyls have been found to be superior for multiplexing applications in twisted nematic cells to equivalent mixtures employing 4-n-alkylphenyl 4-n-alkoxybenzoates or 4-n-al-koxyphenyl trans-4-n-alkylcyclohexane-1-carboxylates.
A novel laboratory-based hard X-ray photoelectron spectroscopy system (2018)

Hard X-ray photoelectron spectroscopy (HAXPES) has seen continuous development since the first experiments in the 1970s. HAXPES systems are predominantly located at synchrotron sources due to low photoionization cross sections necessitating high X-ray intensities, which limits the technique's availability to a wide range of users and potential applications. Here, a new laboratory-based instrument capable of delivering monochromated X-rays with an energy of 9.25 keV and a microfocused 30 × 45 μm<sup>2</sup> X-ray spot is introduced. The system gives an excellent energy resolution of below 500 meV coupled with good X-ray intensity. It allows stable measurements under grazing incidence conditions to maximise signal intensities. This article outlines the instrument behavior, showcases applications including bulk and multilayer measurements, and describes the overall performance of the spectrometer. This system presents an alternative to synchrotron-based experimental end stations and will help expand the number and range of HAXPES experiments performed in the future.
Secretion of the <i>Caulobacter crescentus</i> S-Layer Protein: Further Localization of the C-Terminal Secretion Signal and Its Use for Secretion of Recombinant Proteins (2000)

The secretion signal of the Caulobacter crescentus S-layer protein (RsaA) was localized to the C-terminal 82 amino acids of the molecule. Protein yield studies showed that 336 or 242 C-terminal residues of RsaA mediated secretion of >50 mg of a cellulase passenger protein per liter to the culture fluids.
Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia (2008)

1alpha,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], a vitamin D receptor (VDR) ligand, regulates calcium homeostasis and also exhibits noncalcemic actions on immunity and cell differentiation. In addition to disorders of bone and calcium metabolism, VDR ligands are potential therapeutic agents in the treatment of immune disorders, microbial infections, and malignancies. Hypercalcemia, the major adverse effect of vitamin D(3) derivatives, limits their clinical application. The secondary bile acid lithocholic acid (LCA) is an additional physiological ligand for VDR, and its synthetic derivative, LCA acetate, is a potent VDR agonist. In this study, we found that an additional derivative, LCA propionate, is a more selective VDR activator than LCA acetate. LCA acetate and LCA propionate induced the expression of the calcium channel transient receptor potential vanilloid type 6 (TRPV6) as effectively as that of 1alpha,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1), whereas 1,25(OH)(2)D(3) was more effective on TRPV6 than on CYP24A1 in intestinal cells. In vivo experiments showed that LCA acetate and LCA propionate effectively induced tissue VDR activation without causing hypercalcemia. These bile acid derivatives have the ability to function as selective VDR modulators.
Multistage Centrifugal Compressor Surge Analysis: Part II—Numerical Simulation and Dynamic Control Parameters Evaluation (1999)

This paper describes, from a theoretical point of view, the behavior of compression systems during surge and the effect of passive and active control devices on the instability limit of the system. A lumped parameter model is used to simulate the compression system described in Part I of this work (Arnulfi et al., 1999), based on an industrial multistage centrifugal compressor. A comparison with experimental results shows that the model is accurate enough to describe quantitatively all the features of the phenomenon. A movable wall control system is studied in order to suppress surge in the compressor. Passive and active control schemes are analyzed; they both address directly the dynamic behavior of the compression system to displace the surge line to lower flow rates. The influence of system, geometry and compressor speed is investigated: the optimum values of the control parameters and the corresponding increase in the extent of the stable operating range are presented in the paper.
Recognition of a Mr 56K glycoprotein on the surface of <i>Plasmodium falciparum</i> merozoites by mouse monoclonal antibodies. (1985)

Hybridomas were prepared from mice repeatedly injected with disrupted Plasmodium falciparum (FVO isolate) schizonts and merozoites. Antibodies secreted by two of these hybridomas were shown by immunoelectron microscopy to bind to the surface of merozoites from the FVO isolate. These monoclonal antibodies (McAb) reacted with the FVO and Geneva isolates by an indirect fluorescence antibody test (IFAT) and immunoprecipitated a protein of relative molecular weight (Mr) 56K from both isolates. The 56K protein could be labeled with [35S] methionine and [3H]glucosamine. Glycosidase treatment of the affinity-purified polypeptide proved that the [3H]glucosamine had been incorporated into sugar side chains and that this protein (called gp56) was glycosylated. The anti-gp56 McAb did not react by IFAT or immunoprecipitation with four isolates (Honduras I, Indochina I, Tanzania I, and Kenya) that lack gp56 but contain major glycoproteins of Mr 50K. Antibodies from an Aotus monkey immune to the FVO isolate immunoprecipitated gp56 from both the FVO and Geneva isolates, but did not immunoprecipitate the 50K glycoproteins from the other four isolates. Extraction experiments conducted with the nonionic detergent Triton X-114 indicate that some of the gp56 molecules are hydrophilic and that the others are either hydrophobic or interact with hydrophobic molecules. These results, together with the electron microscopic data, suggest that the hydrophilic gp56 is a component of the extracellular matrix and that the hydrophobic gp56 may be associated with the plasma membrane of the merozoite.
Cell-Based Screening: Cellular Assays with a Molecular Endpoint Measured by SAMDI Mass Spectrometry (Small 28/2016) (2016)

On page 3811, M. Mrksich and co-workers culture cells using self-assembled monolayers presenting cell adhesion ligands and enzyme substrates. A lysis buffer disrupts the cell membranes, releasing enzymes that modify the immobilized substrates. These modifications can be measured with SAMDI mass spectrometry, giving a high-throughput, cell-based assay.
ChemInform Abstract: Moenomycin Family Antibiotics: Chemical Synthesis, Biosynthesis, and Biological Activity (2011)

Abstract Review: 214 refs.
Enhancing Security by Diversifying Instruction Sets (2014)

Despite the variety of choices regarding hardware and software, to date a large number of computer systems remain identical. Characteristic examples of this trend are Windows on x86 and Android on ARM. This homogeneity, sometimes referred to as â€œcomputing oligoculture", provides a fertile ground for malware in the highly networked world of today. One way to counter this problem is to diversify systems so that attackers cannot quickly and easily compromise a large number of machines. For instance, if each system has a different ISA, the attacker has to invest more time in developing exploits that run on every system manifestation. It is not that each individual attack gets harder, but the spread of malware slows down. Further, if the diversified ISA is kept secret from the attacker, the bar for exploitation is raised even higher. In this paper, we show that system diversification can be realized by enabling diversity at the lowest hardware/software interface, the ISA, with almost zero performance overhead. We also describe how prac- tical development and deployment problems of diversified systems can be handled easily in the context of popular software distrbution models, such as the mobile app store model. We demonstrate our proposal with an OpenSPARC FPGA prototype.
Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold (2015)

Peptide-based agents derived from well-defined scaffolds offer an alternative to antibodies for selective and high-affinity recognition of large and topologically complex protein surfaces. Here, we describe a strategy for designing oligomers containing both α- and β-amino acid residues ("α/β-peptides") that mimic several peptides derived from the three-helix bundle "Z-domain" scaffold. We show that α/β-peptides derived from a Z-domain peptide targeting vascular endothelial growth factor (VEGF) can structurally and functionally mimic the binding surface of the parent peptide while exhibiting significantly decreased susceptibility to proteolysis. The tightest VEGF-binding α/β-peptide inhibits the VEGF165-induced proliferation of human umbilical vein endothelial cells. We demonstrate the versatility of this strategy by showing how principles underlying VEGF signaling inhibitors can be rapidly extended to produce Z-domain-mimetic α/β-peptides that bind to two other protein partners, IgG and tumor necrosis factor-α. Because well-established selection techniques can identify high-affinity Z-domain derivatives from large DNA-encoded libraries, our findings should enable the design of biostable α/β-peptides that bind tightly and specifically to diverse targets of biomedical interest. Such reagents would be useful for diagnostic and therapeutic applications.
<title>Radar images of Logan Airport and application in automated aircraft tracking</title> (1994)

To enhance safety and expedite aircraft traffic control at airports, the Federal Aviation Administration (FAA) is in the process of developing automation aids for controllers and pilots. These automation improvements depend on reliable surveillance of the airport traffic, in the form of computerized target reports for all aircraft. One means of surveillance of the airport is primary radar. A short range radar of this type is called airport surface detection equipment or (ASDE). Lincoln Laboratory is participating in this development program by testing a system of surveillance and automation aids at Logan International Airport in Boston, Mass. This work is sponsored by the FAA. This paper describes the radar equipment being used for surface surveillance at Logan Airport and the characteristics of the radar images it produces. Techniques for automatic tracking of this radar data are also described along with a summary of the tracking performance that has been achieved. Two companion papers in this session relate to this same radar surveillance and provide more in-depth descriptions of the radar processing.
Ghost loads (2019)

Speculative execution is necessary for achieving high performance on modern general-purpose CPUs but, starting with Spectre and Meltdown, it has also been proven to cause severe security flaws. In case of a misspeculation, the architectural state is restored to assure functional correctness but a multitude of microarchitectural changes (e.g., cache updates), caused by the speculatively executed instructions, are commonly left in the system. These changes can be used to leak sensitive information, which has led to a frantic search for solutions that can eliminate such security flaws. The contribution of this work is an evaluation of the cost of hiding speculative side-effects in the cache hierarchy, making them visible only after the speculation has been resolved. For this, we compare (for the first time) two broad approaches: i) waiting for loads to become non-speculative before issuing them to the memory system, and ii) eliminating the side-effects of speculation, a solution consisting of invisible loads (Ghost loads) and performance optimizations (Ghost Buffer and Materialization). While previous work, InvisiSpec, has proposed a similar solution to our latter approach, it has done so with only a minimal evaluation and at a significant performance cost. The detailed evaluation of our solutions shows that: i) waiting for loads to become non-speculative is no more costly than the previously proposed InvisiSpec solution, albeit much simpler, non-invasive in the memory system, and stronger security-wise; ii) hiding speculation with Ghost loads (in the context of a relaxed memory model) can be achieved at the cost of 12% performance degradation and 9% energy increase, which is significantly better that the previous state-of-the-art solution.
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis (2003)

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transporter genes involved in promoting bile acid clearance and represses genes involved in bile acid biosynthesis. We investigated whether the synthetic FXR agonist GW4064 could protect against cholestatic liver damage in rat models of extrahepatic and intrahepatic cholestasis. In the bile duct-ligation and -naphthylisothiocyanate models of cholestasis, GW4064 treatment resulted in significant reductions in serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase, as well as other markers of liver damage. Rats that received GW4064 treatment also had decreased incidence and extent of necrosis, decreased inflammatory cell infiltration, and decreased bile duct proliferation. Analysis of gene expression in livers from GW4064-treated cholestatic rats revealed decreased expression of bile acid biosynthetic genes and increased expression of genes involved in bile acid transport, including the phospholipid flippase MDR2. The hepatoprotection seen in these animal models by the synthetic FXR agonist suggests FXR agonists may be useful in the treatment of cholestatic liver disease.
The <i>Neisseria meningitidis</i> haemoglobin receptor: its role in iron utilization and virulence (1995)

The Neisseria meningitidis haemoglobin receptor gene, hmbR, was cloned by complementation in a porphyrin-requiring Escherichia coli mutant. hmbR encodes an 89.5 kDa outer membrane protein which shares amino acid homology with the TonB-dependent receptors of Gram-negative bacteria. HmbR had the highest similarity to Neisseria transferrin and lactoferrin receptors. The utilization of haemoglobin as an iron source required internalization of the haemin moiety by the cell. The mechanism of haemin internalization via the haemoglobin receptor was TonB-dependent in E. coli. A N. meningitidis hmbR mutant was unable to use haemoglobin but could still use haemin as a sole iron source. The existence of a second N. meningitidis receptor gene, specific for haemin, was shown by the isolation of cosmids which did not hybridize with the hmbR probe, but which were able to complement an E. coli hemA aroB mutant on haemin-supplemented plates. The N. meningitidis hmbR mutant was attenuated in an infant rat model for meningococcal infection, indicating that haemoglobin utilization is important for N. meningitidis virulence.
Fuzzy LDA for face recognition with GA based optimization (2010)

The paper addresses the face recognition problem by modifying the Fuzzy Fisherface classification method. In conventional methods, the relationship of each face to a class is assumed to be crisp. The Fuzzy Fisherface method introduces a gradual level of assignment of each face pattern to a class, using a membership grading based upon the K-Nearest Neighbor (KNN) algorithm. This method was further modified by incorporating the membership grade of each face pattern into the calculation of the between-class and with-in class scatter matrices, termed as Complete Fuzzy LDA (CFLDA). Both Fuzzy Fisherface and CFLDA methods utilize the Fuzzy-KNN algorithm. The present work aims at improving the assignment of class membership by improving the parameters of the membership functions. A genetic algorithm is employed to optimize these parameters by searching the parameter space. Furthermore, the genetic algorithm is used to find the optimal number of nearest neighbors to be considered during the training phase. The experiments were performed on the ORL (Olivetti Research Laboratory) face image database and the results show consistent improvement in the recognition rate when compared to the results from other techniques applied on the same database and reported in literature.
Fabrication and characterization of diamond moth eye antireflective surfaces on Ge (1992)

An antireflective coating on Ge which combines a polycrystalline diamond film with a surface relief (moth eye) structure has been designed and successfully fabricated. This progressive gradation in the effective refractive index between air and the substrate has reduced Fresnel reflection losses to below 1%. This provides a means of overcoming the high refractive index and surface roughness considerations that often limit optical application of polycrystalline diamond thin films.
Reciprocating optical modulation for harmonic generation (2001)

The authors propose a novel optical modulation system for generating high-order harmonics, by using two filters placed at the optical input and output ports of an optical modulator. By reciprocating optical modulation at 30 GHz, the sixth-order harmonic, whose frequency is shifted by 180 GHz, is generated effectively.