gebhart/patrepeval huggingface dataset:
The induction of operational tolerance is not prevented by simultaneous administration of cyclosporin A (1997)

Abstract. In this study, the effect of combining anti-CD4 monoclonal antibody (mAb) and cyclosporin (CyA) therapy at the time of transplantation was examined. A mouse cardiac allograft model was used. Anti-CD4 mAb administered peri-operatively induces long-term survival. The addition of a short course of CyA given subcutaneously in a regimen of either a high-dose treatment or a standard dose treatment to the anti-CD4 mAb treatment protocol did not have a detrimental effect on graft survival. Despite having no significant effect on graft survival, the addition of CyA to the treatment protocol did result in a significant decrease in the level of IL-2 present in the hearts 7 days after transplantation. The decrease in IL-2 production was directly related to the presence of CyA in vivo. When CyA treatment was continued throughout the period during which unresponsiveness to the graft is induced by anti-CD4 mAb therapy, 50 % of the grafted hearts were rejected once the CyA was discontinued. In conclusion, the combined use of anti-CD4 mAb therapy and CyA did not have a negative effect on graft survival in this model when the two agents were used concurrently at the time of transplantation.
Influence of electric-magnetic composite field on WC particles distribution in laser melt injection (2016)

Automatic Welding, 2016, №04. Journal «AVTOMATICHESKAYA SVARKA» Monthly scientific-technical and production journal. ISSN: 0005-111X, Since 1948. Russian version of «The PATON Welding Journal» Text in Russian, contents and summaries in English. The Journal presents a wide range of scientific-technical and promotion information in the field of technologies, equipment and materials for welding, surfacing, brazing, and deposition of protective coatings.
Intrusion Detection in Computer Networks based on Machine Learning Algorithms (2008)

Network security technology has become crucial in protecting government and industry computing infrastructure. Modern intrusion detection applications face complex requirements; they need to be reliable, extensible, easy to manage, and have low maintenance cost. In recent years, machine learning-based intrusion detection systems have demonstrated high accuracy, good generalization to novel types of intrusion, and robust behavior in a changing environment. This work aims to compare efficiency of machine learning methods in intrusion detection system, including artificial neural networks and support vector machine, with the hope of providing reference for establishing intrusion detection system in future. Compared with other related works in machine learning-based intrusion detectors, we propose to calculate the mean value via sampling different ratios of normal data for each measurement, which lead us to reach a better accuracy rate for observation data in real world. We compare the accuracy, detection rate, false alarm rate for 4 attack types. The extensive experimental results on the KDD-cup intrusion detection benchmark dataset demonstrate that the proposed approach produces higher performance than KDD Winner, especially for U2R and U2L type attacks. Key words:
How far are we going in colorectal cancer? (2013)

In June, Chinese Clinical Oncology has launched a special issue dedicated to colorectal cancer (www.thecco.net/issue/ view/112) aiming to provide a state of art knowledge in colorectal cancer.
<i>Escherichia coli</i>Strains Belonging to Phylogenetic Group B2 Have Superior Capacity to Persist in the Intestinal Microflora of Infants (2005)

Escherichia coli strains segregate into 4 phylogenetic groups, designated "A," "B1," "B2," and "D." Pathogenic strains belong to group B2 and, to a lesser extent, group D, which more frequently carry virulence-factor genes than do group A strains and group B1 strains. This study investigated whether the capacity of E. coli to persist in the human intestine is related to its phylogenetic type. Resident (n=58) and transient (n=19) commensal E. coli strains isolated during a longitudinal study of 70 Swedish infants and previously tested for virulence-factor-gene carriage were tested for phylogenetic type. Of the strains resident in the intestinal microflora, 60% belonged to group B2, compared with only 21% of the transient strains (P=.004). In logistic regression, group B2 type predicted persistence in the intestinal microflora, independent of carriage of all investigated virulence-factor genes, including genes for P fimbriae (P=.03). Thus, group B2 strains appear to possess yet unidentified traits that enhance their survival in the human intestine.
Synthesis of Ag/ZnO/C plasmonic photocatalyst with enhanced adsorption capacity and photocatalytic activity to antibiotics (2015)

A novel Ag/ZnO/C plasmonic photocatalyst was synthesized<italic>via</italic>a facile calcination and photodeposition route.
Loudness discomfort levels: A retrospective study comparing data from Pascoe (1988) and Washington University School of Medicine (2006)

Loudess discomfort levels (LDLs) were gathered from three Washington University School of Medicine sites, for a total of 325 subjects (total ears=454). These levels were compared to mean LDLs reported by Pascoe (1988). The results revealed that the mean LDL measured at WUSM (ie., the IHAFF procedure) is significantly different that the LDL reported by Pascoe (1988).
[Testing of acute myeloid leukemia of humans using monoclonal antibodies BL-DR, BL-M/G, BL-T2 and BL-Ig-L/1]. (1988)

The leukemic blasts of 22 patients with acute myelocytic and myelomonocytic leukemia were tested by indirect immunofluorescence with the monoclonal antibodies BL-DR (directed against HLA-DR-antigens), BL-M/G (react with both granulocytes and monocytes), BL-T2 (pan-T-lymphocyte-antibody CD 5), and BL-Ig-L/1 (anti-light-chains-antibody). The leukemic blasts showed no crossreaction with BL-DR and BL-Ig-L/1. Both the antibodies BL-DR and BL-M/G reacted mainly with the acute myelomonocytic leukemias FAB M4 and only seldom with the acute myelocytic leukemias FAB M1, M2, and M3. The antibodies BL-DR and BL-M/G are able to confirm the diagnosis of acute myelomonocytic leukemia and to classify some previously unclassifiable leukemias.
Le tribù romane nella regio V e nella parte adriatica della regio VI (2010)

Poiché vi è uno stretto rapporto tra le vicende storiche del territorio (conquista da parte di Roma, fondazione delle colonie, creazione dei municipi, alternarsi della condizione giuridica del municipio a quella della colonia, e viceversa) e la registrazione degli abitanti in determinati distretti elettorali (tribus), l’argomento viene qui affrontato – nell’ambito di uno specifico convegno dedicato al tema delle tribù romane – in riferimento alle comunità antiche del territorio marchigiano. E ciò tenendo conto del fatto che mentre sulla parte settentrionale di esso (Umbria et ager Gallicus) esiste uno studio abbastanza recente (G. Forni 1982), per quella meridionale (Picenum) l’unico lavoro risale alla fine dell’Ottocento (J.W. Kubitschek 1889), mentre lo sviluppo della riflessione storiografica e il moltiplicarsi delle acquisizioni epigrafiche sono nel frattempo a modificare il quadro delle nostre conoscenze. Il lavoro procede dunque ad esaminare le varie e molteplici attestazioni di tribù romane nel territorio in esame in rapporto alle vicende storiche che nello stesso hanno avuto via via luogo. Si affrontano così questioni complesse e delicate, relative alla politica perseguita da Roma nella gestione dei territori conquistati, come è il caso – per esempio – dell’ager Gallicus, su cui ferve da tempo un dibattito intenso.
Towards usable and relevant model checking techniques for the analysis of dependable interactive systems (2002)

Model checking is a formal technique for the automated analysis of system models against formal requirements. Once a suitable model and property have been specified, no further interaction by the analyst is required. However, this does not make the method necessarily user friendly since the checker must be provided with appropriate and complex input data. Furthermore, counter-examples generated by the system are often difficult to interpret. Because of this complexity, model checking is not commonly used, and exhaustive exploration of system models based on finite state descriptions is not exploited within industrial dependable systems design. The paper describes the development of an integrated collection of tools around SMV, intended to make it more accessible to practicing software engineers and in particular those concerned with the human interface issues in complex safety critical systems.
Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents (2014)

In the recent years, organometallic compounds have become recognized as promising anti-cancer drug candidates. While radioactive (186/188)Re compounds are already used in clinics for cancer treatment, cold Re organometallic compounds have mostly been explored as luminescent probes for cell imaging and photosensitizers in photocatalysis. However, a growing number of studies have recently revealed the potential of Re organometallic complexes as anti-cancer agents. Several compounds have displayed cytotoxicity equaling or exceeding that of the well-established anti-cancer drug cisplatin. In this review, we present the currently known Re organometallic complexes that have shown anti-proliferative activity on cancer cell lines. A particular emphasis is placed on their cellular uptake and localization as well as their potential mechanism of action.
1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry (2014)

ADVERTISEMENT RETURN TO ISSUEPREVReview1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials ChemistryYang Hu, Cui-Yun Li, Xiao-Ming Wang, Yong-Hua Yang*, and Hai-Liang Zhu*View Author Information State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China*E-mail: [email protected]*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 10, 5572–5610Publication Date (Web):April 9, 2014Publication History Received27 February 2013Published online9 April 2014Published inissue 28 May 2014https://pubs.acs.org/doi/10.1021/cr400131uhttps://doi.org/10.1021/cr400131ureview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views17399Altmetric-Citations411LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Inhibitors,Nitrogen,Pest control,Reaction products,Substituents Get e-Alerts
Variability of retinal steepness at the posterior pole in children 7–15 years of age (2003)

Although the standard deviations were large, significant differences in relative peripheral EL and SER between refractive groups as well as a significant correlation between relative peripheral EL and SER were observed at several of the assessed locations. CONCLUSIONS. The results strongly suggest that peripheral refraction is correlated with retinal steepness and that previously observed variability in peripheral refraction chiefly reflects variability in retinal steepness. If peripheral refraction represents a determining parameter in the control of eye growth, the precise measurement of retinal steepness could be used not only to improve estimates of myopic progression, but also to identify children who are at high risk of developing myopia. It may lead to specialized clinical/optical treatments, e.g. the correction of not only axial but also peripheral refractive errors, which are more effective than current treatments in individuals who are at risk of myopia development or progression.
The Unravelling of the Genetic Architecture of Plasminogen Deficiency and its Relation to Thrombotic Disease (2016)

Although plasminogen is a key protein in fibrinolysis and several mutations in the plasminogen gene (PLG) have been identified that result in plasminogen deficiency, there are conflicting reports to associate it with the risk of thrombosis. Our aim was to unravel the genetic architecture of PLG in families with plasminogen deficiency and its relationship with spontaneous thrombotic events in these families. A total of 13 individuals from 4 families were recruited. Their genetic risk profile of thromboembolism was characterized using the Thrombo inCode kit. Only one family presented genetic risk of thromboembolism (homozygous carrier of F12 rs1801020 and F13A1 rs5985). The whole PLG was tested using Next Generation Sequencing (NGS) and 5 putative pathogenic mutations were found (after in silico predictions) and associated with plasminogen deficiency. Although we can not find genetic risk factors of thrombosis in 3 of 4 families, even the mutations associated with plasminogen deficiency do not cosegregated with thrombosis, we can not exclude plasminogen deficiency as a susceptibility risk factor for thrombosis, since thrombosis is a multifactorial and complex disease where unknown genetic risk factors, in addition to plasminogen deficiency, within these families may explain the thrombotic tendency.
Elimination of<scp>d</scp>-Lactate Synthesis Increases Poly(3-Hydroxybutyrate) and Ethanol Synthesis from Glycerol and Affects Cofactor Distribution in Recombinant<i>Escherichia coli</i> (2010)

The effect of eliminating D-lactate synthesis in poly(3-hydroxybutyrate) (PHB)-accumulating recombinant Escherichia coli (K24K) was analyzed using glycerol as a substrate. K24KL, an ldhA derivative, produced more biomass and had altered carbon partitioning among the metabolic products, probably due to the increased availability of carbon precursors and reducing power. This resulted in a significant increase of PHB and ethanol synthesis and a decrease in acetate production. Cofactor measurements revealed that cultures of K24K and K24KL had a high intracellular NADPH content and that the NADPH/NADP(+) ratio was higher than the NADH/NAD(+) ratio. The ldhA mutation affected cofactor distribution, resulting in a more reduced intracellular state, mainly due to a further increase in NADPH/NADP(+). In 60-h fed-batch cultures, K24KL reached 41.9 g·liter⁻¹ biomass and accumulated PHB up to 63% ± 1% (wt/wt), with a PHB yield on glycerol of 0.41 ± 0.03 g·g⁻¹, the highest reported using this substrate.
Learning Synchronous Grammars for Semantic Parsing with Lambda Calculus (2007)

This paper presents the first empirical results to our knowledge on learning synchronous grammars that generate logical forms. Using statistical machine translation techniques, a semantic parser based on a synchronous context-free grammar augmented with λ-operators is learned given a set of training sentences and their correct logical forms. The resulting parser is shown to be the best-performing system so far in a database query domain.
P6C-9 An Ultrasound Phantom with Long-Term Stability Using a New Biomimic Soft Gel Material (2007)

We developed an ultrasound phantom with long-term stability using a new biomimic soft gel material, which substantially consists of a swollen Segmented Polyurethane Gel (S-SPUG) and conforms to the standard, IEC 61391-1 Ed 1.0 in acoustic properties.
Event-Driven Approach for Logic-Based Complex Event Processing (2009)

In this paper, we present a powerful logical encoding of complex event patterns into Transaction Logic programs. Complex Event Processing (CEP) deals with finding composed events and has useful applications in areas ranging from agile business and enterprise processes management, financial market applications to active Web and service oriented computation. Many systems for event processing have ad-hoc semantics with unexpected behaviors. Hence formal logical semantics is an important requirement for event-driven reactive systems. On the other hand, many logic-based approaches for CEP (based on formal semantics) fail, due to their inability to compute complex events in the data-driven fashion. Our approach enables both logic-based and data-driven complex event detection. Moreover, the proposed backward chaining approach allows for very efficient reasoning of complex events and actions triggered by these events.
Effect of temperature on the optical properties of<i>ex vivo</i>human dermis and subdermis (1998)

The effect of temperature on the optical properties of human dermis and subdermis as a function of near-infrared wavelength has been studied between 25 degrees C and 40 degrees C. Measurements were performed ex vivo on a total of nine skin samples taken from the abdomen of three individuals. The results show a reproducible effect of temperature on the transport scattering coefficient of dermis and subdermis. The relative change of the transport scattering coefficient showed an increase for dermis ((4.7+/-0.5) x 10(-3) degrees C(-1)) and a decrease for subdermis ((-1.4+/-0.28) x 10(-3) degrees C(-1)). Note that the magnitude of the temperature coefficient of scattering was greater for dermis than subdermis. A reproducible effect of temperature on the absorption coefficient could not be found within experimental errors. System reproducibility in transport scattering coefficient with repeated removal and repositioning of the same tissue sample at the same temperature was excellent at +/-0.35% for all measurements. This reproducibility enabled such small changes in scattering coefficient to be detected.
Video Browsing on Handheld Devices—Interface Designs for the Next Generation of Mobile Video Players (2008)

This paper gives an overview of a group's recent and ongoing work on creating a flexible, intuitive, and powerful interface to improve video browsing on handheld devices in a similar way to how the iPhone's interaction techniques revolutionized navigation in mobile static media. This paper presented several developed and evaluated concepts and related user-interface designs. The paper limit the discussion to the presentation of the designs and refer to the related publications for detailed descriptions of evaluations and user studies.
Real time intention recognition (2016)

Automatic detection of emotions has many applications, but there is the capacity for improvement with respect to level of automation, accuracy, and speed. A system for recognizing emotions through facial expressions in live video streams and video sequences is presented in this paper. We have implemented an Active shape Model (ASM) tracker, which tracks 116 facial landmarks via web-cam input. The tracked landmark points are used to extract face expression features. An Support Vector Machine (SVM) based classifier is implemented which gives rise to robust our system by recognizing seven expressions rather than only six expression as in the most of face expression systems. This technique is applied for the automated identification of the psychological state that exhibits a very strong correlation with the detected features.
BDNF+/− mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain (2010)

Previous work indicated that brain-derived neurotrophic factor (BDNF), through the trkB receptor, increases DNA synthesis in oligodendrocyte (OLG) progenitor cells (OPCs) and differentiation of postmitotic OLGs of the basal forebrain (BF). In the present studies, BDNF knockout animals were used to investigate BDNF's effects on OLG lineage cells (OLCs) in vivo. OLCs of the BF were found to express the trkB receptor, suggesting they are responsive to BDNF. Immunohistochemistry using NG2 and CC1 antibodies was utilized to examine the numbers of NG2+ OPCs and CC1+ postmitotic BF OLGs. At embryonic day 17 (E17), BDNF-/- animals display reduced NG2+ cells. This reduction was also observed in BDNF+/- mice at E17 and at postnatal day 1 (P1), P14, and adult stage, suggesting that BDNF plays a role in OPC development. BDNF+/- mice do not exhibit deficits in numbers of CC1+ OLGs. However, myelin basic protein, myelin associated glycoprotein, and proteolipid protein are reduced in BDNF+/- mice, suggesting that BDNF plays a role in differentiation. These data indicate that progenitor cells and myelin proteins may be affected in vivo by a decrease in BDNF.
Obtaining Thickness Maps of Corneal Layers Using the Optimal Algorithm for Intracorneal Layer Segmentation (2016)

Optical Coherence Tomography (OCT) is one of the most informative methodologies in ophthalmology and provides cross sectional images from anterior and posterior segments of the eye. Corneal diseases can be diagnosed by these images and corneal thickness maps can also assist in the treatment and diagnosis. The need for automatic segmentation of cross sectional images is inevitable since manual segmentation is time consuming and imprecise. In this paper, segmentation methods such as Gaussian Mixture Model (GMM), Graph Cut, and Level Set are used for automatic segmentation of three clinically important corneal layer boundaries on OCT images. Using the segmentation of the boundaries in three-dimensional corneal data, we obtained thickness maps of the layers which are created by these borders. Mean and standard deviation of the thickness values for normal subjects in epithelial, stromal, and whole cornea are calculated in central, superior, inferior, nasal, and temporal zones (centered on the center of pupil). To evaluate our approach, the automatic boundary results are compared with the boundaries segmented manually by two corneal specialists. The quantitative results show that GMM method segments the desired boundaries with the best accuracy.
A High-Throughput Method for the Conversion of CO<sub>2</sub> Obtained from Biochemical Samples to Graphite in Septa-Sealed Vials for Quantification of <sup>14</sup>C via Accelerator Mass Spectrometry (2003)

The growth of accelerator mass spectrometry as a tool for quantitative isotope ratio analysis in the biosciences necessitates high-throughput sample preparation. A method has been developed to convert CO(2) obtained from carbonaceous samples to solid graphite for highly sensitive and precise (14)C quantification. Septa-sealed vials are used along with commercially available disposable materials, eliminating sample cross contamination, minimizing complex handling, and keeping per sample costs low. Samples containing between 0.25 and 10 mg of total carbon can be reduced to graphite in approximately 4 h in routine operation. Approximately 150 samples per 8-h day can be prepared by a single technician.