gebhart/patrepeval huggingface dataset:
Passive implementation for a class of static nonlinear environments in haptic display (2003)

This paper derives conditions for the absence of oscillations for a parametrized class of nonlinear environments. This class includes discrete-time environments that can exhibit non-passive behavior. The motivation for considering non-passive discrete-time environments is based on the fact that an interesting class of passive continuous-time environments have non-passive discrete-time counterparts. A design methodology is introduced that provides relationships between the haptic device, virtual coupling and maximum negative stiffness exhibited by the environment.
Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health (2016)

Functional oral supplements containing cell membrane glycerolphospholipids and antioxidants have been used to safely replace damaged membrane lipids that accumulate during aging and in various clinical conditions. This approach differs from other dietary and intravenous interventions in the composition of phospholipids and the presence of fructooligosaccharides that protect the phospholipids against oxidation and bile and enzymatic damage. Various chronic clinical conditions are characterized by membrane phospholipid oxidative damage, resulting in loss of cellular function. Recent clinical trials have shown the benefits of Membrane Lipid Replacement in replenishing damaged membrane lipids and restoring mitochondrial function, resulting in reductions in fatigue in aged subjects and patients with a variety of clinical diagnoses. Recent in vitro experiments with nonphysiological concentrations of phospholipids did not result in enhancement of mitochondrial electron transport enzyme activities. This can be explained by the use of the wrong phospholipid fatty acids, over-dilution of membrane constituents and mitochondrial swelling. A similar phenomenon was seen when human sperm were incubated in vitro with high concentrations of glycerolphospholipids and their motility was assessed. Only lower, more physiological concentrations of glycerolphospholipids stimulated sperm motility. Additional studies are needed to determine the functional effects of Membrane Lipid Replacement on other cellular membranes, such as the plasma membrane and other intracellular membranes of various cells and tissues.
Novel Synthesis of 2-Arylbenzothiazoles Mediated by Ceric Ammonium Nitrate (CAN) (2002)

[reaction: see text] Cyclization of the intermediate radical formed after initial oxidative coupling between thiophenols and aromatic nitriles leads to the synthesis of a wide range of 2-arylbenzothiazoles.
LRP-Mediated Clearance of A&#946; is Inhibited by KPI-Containing Isoforms of APP (2005)

The pathogenesis of Alzheimer's disease (AD) involves the abnormal accumulation and deposition of beta-amyloid in cerebral blood vessels and in the brain parenchyma. Critical in modulating beta-amyloid deposition in brain is the flux of Abeta across the blood brain barrier. The low-density lipoprotein receptor-related protein (LRP), is a large endocytic receptor that mediates the efflux of Abeta out of brain and into the periphery. The first step in the LRP-mediated clearance of Abeta involves the formation of a complex between Abeta and the LRP ligands apolipoprotein E (apoE) or alpha(2)-macroglobulin (alpha(2)M). The Abeta/chaperone complexes then bind to LRP via binding sites on apoE or alpha(2)M. The efflux of Abeta/chaperone complexes out of the neuropil and into the periphery may be attenuated by LRP-ligands that compete with apoE or alpha(2)M for LRP binding. LRP is also the cell surface receptor for Kunitz Protease Inhibitor (KPI) containing isoforms of Abeta's parent protein, the amyloid protein precursor (APP). Protein and mRNA levels of KPI-containing APP isoforms (APP-KPI) are elevated in AD brain and are associated with increased Abeta production. In this study we show that soluble non-amyloidogenic APP-KPI can also inhibit the uptake of Abeta/alpha(2)M in a cell culture model of LRP mediated Abeta clearance. Clearance of Abeta/apoE complexes was not inhibited by APP-KPI. Our findings are consistent with studies showing that apoE and alpha(2)M have discrete binding sites on LRP. Most significantly, our data suggests that the elevated levels of APP-KPI in AD brain may attenuate the clearance of Abeta, the proteins own amyloidogenic catabolic product.
Modification of Flower Colour via Manipulation of P450 Gene Expression in Transgenic Plants (1995)

Unlike animals, which synthesise cytochrome P450 enzymes mostly for the degradation of xenobiotics, plants have evolved a large number of different P450 enzymes for the synthesis of secondary metabolites. Probably the most conspicuous of these secondary metabolites are anthocyanins, which are important flower pigments. The types of anthocyanins synthesised in plants are controlled by the cytochrome P450 enzymes flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase. Cloning of flavonoid 3',5'-hydroxylase genes has enabled the manipulation of anthocyanin synthesis in transgenic plants and enabled the production of novel pigments and flower colours.
Sensitivity of the Zirconia Oxygen Sensor to Temperature and Flow Rate of Exhaust Gas (1976)

<div class="htmlview paragraph">The zirconia oxygen sensor provides a feedback signal for stoichiometric air-fuel ratio (A/F) control of an engine. Precise control of A/F within ±1% of the stoichiometric point is required for effective operation of a three-way catalyst. Since the ultimate accuracy of the closed loop control system directly depends on the accuracy of the oxygen sensor, the present investigation was undertaken to quantify factors affecting sensor accuracy. Measurements were made of the relative importance of engine exhaust flow and exhaust temperature on the voltage output of the zirconia oxygen sensor.</div> <div class="htmlview paragraph">A test engine was run on a dynamometer at fixed speed and load. A special arrangement on the exhaust pipe permitted independent adjustment of exhaust flow and exhaust temperature. Coefficients for the differential changes in sensor voltage due to changes of engine air-fuel ratio, exhaust flow, and exhaust temperature were determined.</div>
<title>The Leuven Automatic Visual Inspection Machine (LAVIM)</title> (1979)

In many production chains visual inspection of products is an important manufacturing consideration with respect to quality control. Recent progress in image processing and pattern recognition led the way to economically justified applications: modern technology enables the construction of such automata featuring high reliability and constancy. This paper describes an automatic visual inspection machine performing intelligent control tasks in very short time. The possible applications include dimension control of products, inspection of objects on shape, grey-Mess or texture, sorting of objects, positioning, etc. The design is based on a fast synthesis procedure of a TV-image by profile extraction. The features to be controlled are extracted from these profiles and compared with upper/lower limits obtained from a learning process. The system performances are expressed by the elaboration of an industrial case: the real-time visual inspection of reed switches. More than 35 features are detected and controlled for each switch within I second. Several experiments with a prototype version have proven the feasible use as an industrial on-line controller.
Lustra, Lustra-AF and Alustra. (2003)

Hydroquinone has been successfully used to treat hyperpigmentation disorders for many years. Recently, new formulations containing hydroquinone have become available, including Lustra and Lustra-AF (Medicis). These products also contain glycolic acid 2%, an active antioxidant system (ascorbyl palmitate and tocopherol acetate), and moisturizers. Lustra-AF also contains a broad-spectrum sunscreen. Alustra contains a stabilized, high-concentration of retinol. The above formulations inhibit melanogenesis, stimulate epidermal desquamation, inhibit free radical-mediated photodamage and restore the antioxidant reservoir. The addition of retinoids may facilitate epidermal penetration of hydroquinone and prevent its oxidation. Comparative studies have shown that these agents can be effective in reducing blotchiness, mottled hyperpigmentation, post-inflammatory hyperpigmentation, and surface roughness. In addition, these formulations have been generally well tolerated with patients rarely reporting mild-to-moderate adverse events such as dryness, redness, or peeling of the skin.
Discharge measurements in cables using a solid state 30 kV bipolar low frequency generator (1988)

A design of a 30 kV, 10 mA VLF power supply has been tested which uses solid state components to produce a device which is low noise, portable and suitable for partial discharge testing of high voltage cables up to 33 kV. The device is designed for use in testing installed high voltage cables. The power supply is sufficiently quiet that wide-band partial discharge measurements on polymeric cables may be performed with sensitivities of a few picoCoulombs. No account has been taken of any external noise. The high voltage current stacks can be controlled to operate at any frequency which the HV rails can supply current. In practice this means DC-10 Hz is the useful operating range for the power supply, depending on cable capacitance. Typical frequencies for 1000 m of installed cable would be in the range 0.1-0.5 Hz. >
Ta-doped Anatase TiO<sub>2</sub> Epitaxial Film as Transparent Conducting Oxide (2005)

We present electrical transport and optical properties of Ta-doped TiO 2 epitaxial thin films with varying Ta concentration grown by the pulsed laser deposition method. The Ti 0.95 Ta 0.05 O 2 film exhibited a resistivity of 2.5×10 -4 Ω cm at room temperature, and an internal transmittance of 95% in the visible light region. These values are comparable to those of a widely used transparent conducting oxide (TCO), indium tin oxide. Furthermore, this new material falls into a new category of TCOs that utilizes d electrons.
Population modelling of the effect of inogatran, at thrombin inhibitor, on <i>ex vivo</i> coagulation time (APTT) in healthy subjects and patients with coronary artery disease (2001)

The nonlinear relationship between APTT and inogatran concentration in plasma was well described by a combined linear and Emax model. Pooling of data was made possible by incorporating a centre-specific characteristic of the assay method in the model. Patients had lower baseline APTT and appeared to have less pronounced effect of inogatran than young healthy subjects.
<i>In Vivo</i> Metabolic Fingerprinting of Neutral Lipids with Hyperspectral Stimulated Raman Scattering Microscopy (2014)

Metabolic fingerprinting provides valuable information on the physiopathological states of cells and tissues. Traditional imaging mass spectrometry and magnetic resonance imaging are unable to probe the spatial-temporal dynamics of metabolites at the subcellular level due to either lack of spatial resolution or inability to perform live cell imaging. Here we report a complementary metabolic imaging technique that is based on hyperspectral stimulated Raman scattering (hsSRS). We demonstrated the use of hsSRS imaging in quantifying two major neutral lipids: cholesteryl ester and triacylglycerol in cells and tissues. Our imaging results revealed previously unknown changes of lipid composition associated with obesity and steatohepatitis. We further used stable-isotope labeling to trace the metabolic dynamics of fatty acids in live cells and live Caenorhabditis elegans with hsSRS imaging. We found that unsaturated fatty acid has preferential uptake into lipid storage while saturated fatty acid exhibits toxicity in hepatic cells. Simultaneous metabolic fingerprinting of deuterium-labeled saturated and unsaturated fatty acids in living C. elegans revealed that there is a lack of interaction between the two, unlike previously hypothesized. Our findings provide new approaches for metabolic tracing of neutral lipids and their precursors in living cells and organisms, and could potentially serve as a general approach for metabolic fingerprinting of other metabolites.
Chronic benign pain (1976)

Pain: December 1976 - Volume 2 - Issue 4 - p 359 doi: 10.1016/0304-3959(76)90078-6
History and Classification of Human Leukemia-Lymphoma Cell Lines (1998)

Continuous human leukemia-lymphoma cell lines have become indispensable tools in hematological research since the establishment of the first human lymphoma cell line Raji in 1963. We summarize here historical landmarks in the establishment of unique leukemia-lymphoma-derived cell lines from the various cell lineages; their special importance in hematopoietic research is emphasized. The first cell lines were derived from African Burkitt lymphomas and were found to integrate the Epstein-Barr virus in their genome leading to the discovery and isolation of this virus. However, it was later recognized that not every cell line derived from a patient with leukemia-lymphoma represents a malignant cell line as residual normal B-lymphocytes can also be immortalized by EBV infection. During the following 20-30 years many other types of hematopoietic cell lines, commonly derived from hematopoietic neoplasms, were established. These panels of cell lines now span almost the whole spectrum of hematopoietic cell lineages (except for dendritric cells) and the various distinct stages of differentiation along the respective cell axes. From early on, cell lines became important tools for basic and clinical hematological research, initially mainly in the field of immunology, but later expanding to other areas also. It became apparent that leukemia-lymphoma cell lines are of monoclonal origin, are arrested at a discrete maturational stage during differentiation in each lineage, and show sustained and growth factor-independent or -dependent unlimited proliferation. Categorization of cell lines might best be based on the physiological stages of hematopoietic differentiation in the various cell lineages. For an adequate classification, detailed characterizations of both the cell lines and the primary cells from which the cell lines originated are absolutely mandatory. In summary, the availability of large numbers of continuous leukemia-lymphoma cell lines has greatly facilitated clinical and immunobiological studies of normal and malignant hematopoiesis. Human leukemia-lymphoma cell lines will continue to provide exquisite model systems for many biomedical disciplines.
Methods to improve detection of pneumococci in respiratory secretions (1975)

Simple methods to enhance the detection of pneumococci in respiratory secretions are needed. Sheep blood agar containing 5 mug of gentamicin per ml was more often positive (89%) than either standard sheep blood agar (54%) or mouse inoculation (65%) in recovering pneumococci from 62 adult and pediatric patients. In adults, the direct quellung test on sputum smear was a rapid, sensitive method for predicting subsequent pneumococcal isolation by culture (19 of 20 patients, 95%). The quellung test and gentamicin plate show improved sensitivity over current techniques for pneumococcal detection and can be recommended for general use.
Optimizing Recursive Information-Gathering Plans (1999)

In this paper we describe two optimization techniques that are specially tailored for information gathering. The first is a greedy minimization algorithm that minimizes an information gathering plan by removing redundant and overlapping information sources without loss of completeness. We then discuss a set of heuristics that guide the greedy minimization algorithm so as to remove costlier information sources first. In contrast to previous work, our approach can handle recursive query plans that arise commonly in practice. Second, we present a method for ordering the access to sources to reduce the execution cost. Sources on the Internet have a variety of access limitations and the execution cost in information gathering is affected both by network traffic and by the connection setup costs. We describe a way of representing the access capabilities of sources, and provide a greedy algorithm for ordering source calls that respects source limitations, and takes both acc...
Fresh Start Or Head Start: Missouri Courts Rethink the Role of Tenancies by the Entirety in Bankruptcy (1991)

Landmark Bank v. Charles (In re Charles) 1 Few issues have caused as much consternation 2 in determining the extent of a debtor's estate in bankruptcy 3 as the treatment to be given property held by the debtor as a tenant by the entirety. 4
25.4: <i>Invited Paper</i>: Development of Commercial Flexible AMOLEDs (2014)

Abstract The 5.98 inch‐sized World's first flexible OLED display has been developed and launched mass production on smartphone with extremely light, thin and curved shape, successfully. We have employed ELA‐TFT on PI backplane, Face‐sealing encapsulation, Laser‐assisted glass release and flexible back‐plate lamination process. These technologies enable panel reliability as well as mass production with inherent flexible display characteristics. For commercializing flexible OLED, technical barriers and challenges on TFT device, panel design and various process technologies including LG Display's recent experience will be presented in this paper.
Automated landmark-guided deformable image registration (2014)

The purpose of this work is to develop an automated landmark-guided deformable image registration (LDIR) algorithm between the planning CT and daily cone-beam CT (CBCT) with low image quality. This method uses an automated landmark generation algorithm in conjunction with a local small volume gradient matching search engine to map corresponding landmarks between the CBCT and the planning CT. The landmarks act as stabilizing control points in the following Demons deformable image registration. LDIR is implemented on graphics processing units (GPUs) for parallel computation to achieve ultra fast calculation. The accuracy of the LDIR algorithm has been evaluated on a synthetic case in the presence of different noise levels and data of six head and neck cancer patients. The results indicate that LDIR performed better than rigid registration, Demons, and intensity corrected Demons for all similarity metrics used. In conclusion, LDIR achieves high accuracy in the presence of multimodality intensity mismatch and CBCT noise contamination, while simultaneously preserving high computational efficiency.
Stimulation of Skin and Wound Fibroblast Migration by Mesenchymal Stem Cells Derived from Normal Donors and Chronic Wound Patients (2012)

Chronic wounds continue to be a major cause of morbidity for patients and an economic burden on the health care system. Novel therapeutic approaches to improved wound healing will need, however, to address cellular changes induced by a number of systemic comorbidities seen in chronic wound patients, such as diabetes, chronic renal failure, and arterial or venous insufficiency. These effects likely include impaired inflammatory cell migration, reduced growth factor production, and poor tissue remodeling. The multifunctional properties of bone marrow-derived mesenchymal stem cells (MSCs), including their ability to differentiate into various cell types and capacity to secrete factors important in accelerating healing of cutaneous wounds, have made MSCs a promising agent for tissue repair and regeneration. In this study we have used an in vitro scratch assay procedure incorporating labeled MSCs and fibroblasts derived from normal donors and chronic wound patients in order to characterize the induction of mobilization when these cells are mixed. A modified Boyden chamber assay was also used to examine the effect of soluble factors on fibroblast migration. These studies suggest that MSCs play a role in skin wound closure by affecting dermal fibroblast migration in a dose-dependent manner. Deficiencies were noted, however, in chronic wound patient fibroblasts and MSCs as compared with those derived from normal donors. These findings provide a foundation to develop therapies targeted specifically to the use of bone marrow-derived MSCs in wound healing and may provide insight into why some wounds do not heal.
A low–power truly–modular 1.8GHz programmable divider in standard CMOS technology (1999)

We present a modular and scalable divider architecture that is especially suited for low power applications. The implementation of the divider cells in SCL is described, and a new design method for power dissipation optimization, based on an AC simulation technique, is introduced. An 18bit implementation of the architecture in a conservative 0.35µm bulk CMOS technology is described, which achieved state-of-the-art power efficiency and input sensitivity for CMOS silicon technologies.
Vehicle Remote Health Monitoring and Prognostic Maintenance System (2018)

In many industries inclusive of automotive vehicle industry, predictive maintenance has become more important. It is hard to diagnose failure in advance in the vehicle industry because of the limited availability of sensors and some of the designing exertions. However with the great development in automotive industry, it looks feasible today to analyze sensor’s data along with machine learning techniques for failure prediction. In this article, an approach is presented for fault prediction of four main subsystems of vehicle, fuel system, ignition system, exhaust system, and cooling system. Sensor is collected when vehicle is on the move, both in faulty condition (when any failure in specific system has occurred) and in normal condition. The data is transmitted to the server which analyzes the data. Interesting patterns are learned using four classifiers, Decision Tree, Support Vector Machine, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>K</mml:mi></mml:mrow></mml:math> Nearest Neighbor, and Random Forest. These patterns are later used to detect future failures in other vehicles which show the similar behavior. The approach is produced with the end goal of expanding vehicle up-time and was demonstrated on 70 vehicles of Toyota Corolla type. Accuracy comparison of all classifiers is performed on the basis of Receiver Operating Characteristics (ROC) curves.