gebhart/patrepeval huggingface dataset:
Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY (1996)

The results of previous biochemical studies indicated that a fraction of MHC class II proteins is associated with four proteins of the tetraspan family, CD37, CD53, CD81, and CD82, and possibly with other membrane components, at the surface of JY B lymphoma cells. In the present communication we used a biophysical technique, namely the flow cytometric energy transfer method, to demonstrate the proximity of these molecules at the surface of the cells. Significant energy transfer (and, therefore, proximity within the 2-10 nm range) was observed between fluorescently labeled mAbs to DR, DQ, and the tetraspan molecules CD53, CD81, and CD82. Moreover, two other B cell surface molecules, CD20 and MHC class I, were found to be close to each other and to MHC class II and the tetraspan proteins, based on the observed high energy transfer efficiencies between the relevant fluorescently labeled mAbs. The character of simultaneous energy transfer from CD20, CD53, CD81, and CD82 to DR suggests that all these molecules are in a single complex with the DR molecules (or a complex of several DR molecules) rather than that each of them is separately associated with different DR molecules. Based on these data and previous biochemical results, a model is proposed predicting that the B cell membrane contains multicomponent supramolecular complexes consisting of at least two MHC class I and at least one DR, DQ, CD20, CD53, CD81, and CD82 molecules. Closer analysis of the energy transfer efficiencies makes it possible to suggest mutual orientations of the components within the complex. Participation of other molecules, not examined in this study (CD19 and CD37), in these supramolecular structures cannot be ruled out. These large assemblies of multiple B cell surface molecules may play a role in signaling through MHC molecules and in Ag presentation to T cells.
Blockchain-Based IoT-Cloud Authorization and Delegation (2018)

In a Smart City scenario, the authors envisioned an IoT-Cloud framework for the management of boards and resources scattered over a geographic area. It can also become a tool to let device owners contribute freely to the infrastructure. In comparison to datacenter-oriented Cloud middleware, the administrator and the owner of the infrastructure are not one and the same. This translates into the requirement to support delegation-enabled authorization. In this paper, the authors investigate an authorization and delegation model for the IoT-Cloud based on blockchain technology. In particular, the scheme is implemented in the form of smart contracts over the Ethereum platform. Indeed, this approach represents an enhancement, over a function previously designed in a centralized fashion, by enabling the user to audit authorization operations and inspect how access control is actually performed, without blindly trusting the Cloud as a proxy for access to resources.
Deep Mutational Scanning Comprehensively Maps How Zika Envelope Protein Mutations Affect Viral Growth and Antibody Escape (2019)

Functional constraints on viral proteins are often assessed by examining sequence conservation among natural strains, but this approach is relatively ineffective for Zika virus because all known sequences are highly similar. Here, we take an alternative approach to map functional constraints on Zika virus's envelope (E) protein by using deep mutational scanning to measure how all amino acid mutations to the E protein affect viral growth in cell culture. The resulting sequence-function map is consistent with existing knowledge about E protein structure and function but also provides insight into mutation-level constraints in many regions of the protein that have not been well characterized in prior functional work. In addition, we extend our approach to completely map how mutations affect viral neutralization by two monoclonal antibodies, thereby precisely defining their functional epitopes. Overall, our study provides a valuable resource for understanding the effects of mutations to this important viral protein and also offers a roadmap for future work to map functional and antigenic selection to Zika virus at high resolution.<b>IMPORTANCE</b> Zika virus has recently been shown to be associated with severe birth defects. The virus's E protein mediates its ability to infect cells and is also the primary target of the antibodies that are elicited by natural infection and vaccines that are being developed against the virus. Therefore, determining the effects of mutations to this protein is important for understanding its function, its susceptibility to vaccine-mediated immunity, and its potential for future evolution. We completely mapped how amino acid mutations to the E protein affected the virus's ability to grow in cells in the laboratory and escape from several antibodies. The resulting maps relate changes in the E protein's sequence to changes in viral function and therefore provide a valuable complement to existing maps of the physical structure of the protein.
Recent progress in piezotronics and tribotronics (2018)

As the electronic technology is approaching its limits of materials and processing, a smart interaction between functional device and environment is a promising way for future electronic technology above the Moore's law. The mechanical signal triggering is the most common and natural way for the smart interactions, which has realized direct interaction between human/ambient and electronics and artificial intelligence. In 2006, the piezotronic effect, as a novel effect, was first proposed by Wang to achieve the effective, adaptive and seamless interactions between electronic devices and the external stress, which utilizes the piezoelectric polarization potential as the virtual gate to tune/control the carriers' transportation in the electronic device. Since then, this new effect has been widely observed in many low-dimensional semiconductors such as ZnO, GaN, CdS nanowires, and 2D MoS<sub>2</sub>. In extension, tribotronics was first proposed in 2014 by Wang, which is about the devices manufactured using the electrostatic potential created by triboelectrification as a 'gate' voltage to tune/control energy transformation and electrical transport in semiconductors for the smart interaction between device and environment. Tribotronics has made rapid research progress and many tribotronic functional devices have been studied with a variety of materials, such as tribotronic tactile switch, memory, hydrogen sensor and phototransistor. This review highlights advances in piezotronics and tribotronics with focus on fundamental theories, nanoscale materials, functional devices and simulations. Our emphasis is mainly about their application for third-generation semiconductor. The concepts and results presented in this review show that the piezotronics and tribotronics will facilitate the development of MEMS/NEMS, self-powered sensing, man-computer interfacing, and active wearable electronics.
Osseointegrated implants in the management of childhood ear abnormalities: the initial Birmingham experience (1993)

Over a four-year period 72 children with ear abnormalities have been referred for assessment by the extraoral osseointegrated implant team at The Queen Elizabeth Hospital, Birmingham. Thirty-two children have been judged suitable for rehabilitation. Twelve children have completed rehabilitation using bone-anchored hearing aids and/or auricular prostheses. Two fixtures (seven per cent of those loaded) have dislodged and required replacement. Audiological assessment of the bone-anchored hearing aid users shows only small improvements in their aided thresholds, compared to thresholds obtained with their previous aid. However all now have thresholds of 30 dB(A) or better and report a marked improvement in sound quality. When surveyed, hearing aid and prosthesis users report high levels of satisfaction with this form of rehabilitation. The technique adds a new dimension to the management of children with aural anomalies. The approach and results of a multidisciplinary programme are reported.
SpiderBot: A cable suspended mobile robot (2011)

SpiderBot is a cable suspended mobile robot that is designed to climb walls and hang from ceilings by shooting tethered plungers onto the surface. Removing the plungers, it reels in the web, aims, and repeats the process to climb farther. SpiderBots' design was inspired by the fictional character Spider-Man. The robot can be used for carrying equipment and sensors over a disaster area to help rescue forces. It can maneuver and serve as a moving platform inside building such as workshops and hangers without taking floor space. The robot can also move between floating vessels at sea and serve as a moving crane.
Angle-of-Arrival Estimation Using Radar Interferometry: Methods and Applications (2013)

Radar interferometers provide a cost-effective radar architecture to achieve enhanced angle accuracy for enhanced target tracking. Presenting a comprehensive understanding of various radar interferometer architectures, Angle of Arrival Estimation Using Radar Interferometry aims to quantify interferometer angle estimation accuracy by developing a general understanding of various radar interferometer architectures and presenting a comprehensive understanding of the effects of radar-based measurement errors on angle-of-arrival estimation. The interferometer architectures described include a basic digital interferometer, a monopulse interferometer, an orthogonal interferometer and signal processing algorithms. By exploring interferometry and beyond, this book offers a unique perspective and an in depth look at the derivation of angle error equations for a radar interferometer as affected not only by additive noise but by other error effects such as multipath, glint, and spectral distortion. As such this book is primarily directed toward tracking radars but will also discuss imaging applications as well.
Acute femoral neck fracture in children--preliminary report. (1989)

Nineteen children, aged 3-15 years, with acute femoral neck fracture were treated. The follow-up period ranged from 2 years to 6 years, 9 months (avg. 54.8 +/- 14.5 months). The clinical and radiological assessments were carried out according to the assessment system of Ratliff. Undisplaced fractures and all intertrochanteric fractures were treated conservatively and displaced ones by reduction and multiple pinning. The outcomes reveal 14 (79%) with good results, 2 (10.5%), fair and 3 (15.8%), poor. Four hips (21%) developed avascular necrosis with 2 requiring secondary surgical procedures. Both of them also had leg length discrepancy. Another 3 hips (15.8%) developed coxa vara, one of them had mild leg length discrepancy.
A study on the optimal attributes of transform domain vector quantization for image and video compression (2002)

The concept of vector transform coding (VTC) is examined. It is noted that the optimal transform for the purpose of vector quantization should reduce the correlation between the transform domain vectors and preserve the correlation among the components within each vector. An intrinsic coupling factor is defined to quantitatively measure how closely the components are coupled within a vector, and a bit-allocation mechanism is derived to assign bits to the transform domain vectors. Following the guidance of such a general study, a new scheme is proposed for image and video compression. Simulation results show excellent subjective quality at a bit-rate of 3.3 Mb/s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Influence of Dehydroepiandrosterone on Rabbit Intraocular Pressure (2000)

The small drug-related effects may be due, in large part, to poor intraocular drug penetration. The circadian rhythm of IOP appears to be time-dependent in chronic studies with a gradual loss of IOP difference between a.m. and p.m. readings.
Packet Loss Concealment for G.722 using Side Information with Application to Voice over Wireless LANs (2007)

The G.722 wideband speech codec offers higher quality and better naturalness than G.711, is low in com- plexity, has low delay, and tandems well with other codecs. This makes it an attractive codec for Voice over IP and Voice over Wireless LANs. However, loss of a G.722 coded speech frame results in a mismatch of the encoder/decoder states that affects the decoding of subsequent correctly received frames. We present a new packet loss concealment (PLC) method for G.722 and propose an efficient approach to sending the side information to improve concealment of the lost frame and to resynchronize the encoder and decoder. The proposed method greatly improves the robustness of the G.722 codec to packet losses for Voice over Wireless LANs. Wideband Perceptual Evaluation of Speech Quality Mean Opinion Score (WB-PESQ MOS) is used as the quality metric for evaluating the performance of the PLC schemes.
Electrolytic extraction drives volatile fatty acid chain elongation through lactic acid and replaces chemical pH control in thin stillage fermentation (2015)

VFA can be extracted directly from a fermentation broth by membrane electrolysis. The electrolytic water reduction products are utilized in the fermentation: OH(-) is used for pH control without added chemicals, and H2 is metabolized by species such as Megasphaera elsdenii to produce greater value, more reduced VFA. Electro-fermentation displays promise for generating added value chemical co-products from biorefinery sidestreams and wastes.
An error concealment scheme for MPEG-2 video transmission over ATM-based networks (2002)

In the process of transmission of digital-encoded video bitstreams over an ATM network, cells are inevitably exposed to delays and losses due to the statistical multiplexing and dynamic resource allocation mechanisms used in these networks. Error-loss concealment techniques have been proposed to limit the impact of such impairments over the video quality. These techniques alone may provide acceptable results when the cell loss probability does not exceed 10/sup -3/. For higher cell loss probabilities, these techniques must be used in conjunction with hierarchical coding schemes and packetization strategies in order to obtain satisfactory results. We propose the use of a hierarchical encoding scheme and a dynamic data-partitioning strategy for the transport of MPEG-2 video streams over ATM networks.
Absolute Calibration of Dual Frequency Timing Receivers for Galileo (2013)

The timing service of Global Navigation Satellite Systems (GNSS) is being steadily improved. Generally, this fact traces back to increasing accuracy of the provided ephemeris data, improvements in Precise Point Positioning, continuous refinement of time transfer techniques, the utilization of modern signals, the use of wider bandwidth, and a growing number of available satellites—the latter particularly due to the coexistence of an increasing number of independent GNSSs available. The accuracy achievable by the GNSS common view time transfer method is within range of nanoseconds. In particular the upcoming Galileo in combination with the Global Positioning System is expected to improve that accuracy even further. In this paper, we present results for an approach for absolute calibration of Galileo timing receivers operating in the L1BC and E5 signal bands. The internal receiver delays for Galileo E1 and GPS L1 signals of the institute’s Septentrio PolaRx4 TR PRO are assessed. The approach utilizes a hardware simulator, which is an expanded version of a GSS7790 GNSS simulator from Spirent Communications. The simulator, the receiver under test, as well as the utilized measurement equipment use the 10 MHz signal from the same cesium clock as reference.
Recognizing Emotional Expression in Game Streams (2019)

Gameplay is often an emotionally charged activity, in particular when streaming in front of a live audience. From a games user research perspective, it would be beneficial to automatically detect and recognize players' and streamers' emotional expression, as this data can be used for identifying gameplay highlights, computing emotion metrics or to select parts of the videos for further analysis, e.g., through assisted recall. We contribute the first automatic game stream emotion annotation system that combines neural network analysis of facial expressions, video transcript sentiment, voice emotion, and low-level audio features (pitch, loudness). Using human-annotated emotional expression data as the ground truth, we reach accuracies of up to 70.7%, on par with the inter-rater agreement of the human annotators. In detecting the 5 most intense events of each video, we reach a higher accuracy of 80.4%. Our system is particularly accurate in detecting clearly positive emotions like amusement and excitement, but more limited with subtle emotions like puzzlement.
Stereospecific synthesis of acyclic unsaturated amino alcohols. A new approach to threo and erythro sphingosine (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific synthesis of acyclic unsaturated amino alcohols. A new approach to threo and erythro sphingosineRavi S. Garigipati and Steven M. WeinrebCite this: J. Am. Chem. Soc. 1983, 105, 13, 4499–4501Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://pubs.acs.org/doi/10.1021/ja00351a074https://doi.org/10.1021/ja00351a074research-articleACS PublicationsRequest reuse permissionsArticle Views350Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Transcriptional activation mediated by binding of a plant GATA‐type zinc finger protein AGP1 to the AG‐motif (AGATCCAA) of the wound‐inducible <i>Myb</i> gene <i>NtMyb2</i> (2003)

NtMyb2 is a regulator of the tobacco retrotransposon Tto1 and the defense-related gene phenylalanine ammonia lyase (PAL), which are induced by various stress stimuli such as wounding or elicitor treatment. NtMyb2 is also induced by wounding or elicitor treatment and is regulated at the transcriptional level. In this study, mutational analysis of the promoter of NtMyb2 and gain-of-function analysis in vivo showed that the sequence AGATCCAA, named the AG-motif, is a cis-element sufficient to confer responsiveness to wounding and elicitor treatment. Furthermore, by using the south-western method, we cloned cDNAs encoding a GATA-type zinc finger protein, which can specifically bind to the AG-motif, named AG-motif binding Protein (AGP1). Domain analysis revealed that not only the GATA-type zinc finger region but also the downstream His2 motif of AGP1 is required for binding activity, showing that the AGP has a novel GATA-type zinc finger domain. AGP1 can activate expression from promoters containing the AG-motif in tobacco protoplasts, indicating that AGP1 is a positive regulator of NtMyb2. We also found that the AGP1 binding activity is highly enhanced by adenine methylation of the AG-motif by bacterial dam methylase.
Role of nontypeable Haemophilus Influenzae in exacerbations and progression of chronic obstructive pulmonary disease (2006)

Though much has been learnt about nontypeable H. influenzae in chronic obstructive pulmonary disease, new therapeutic and preventive approaches require an even greater understanding of this host-pathogen interaction.
An integrated, vertical-drive, in-plane-sense microgyroscope (2004)

This paper describes the principle of operation and experimental results of a Y-axis /spl Sigma//spl Delta/ force-feedback gyroscope. The gyroscope was fabricated in Analog Devices' monolithic Modular-MEMS process with 6/spl mu/m thick structural polysilicon and 0.8/spl mu/m CMOS. The sensor utilizes vertical (Z-axis) actuation of the proof mass to enable in-plane (X-axis) differential sensing of the Coriolis force. Two orthogonally-oriented gyroscopes form a dual-axis rate sensor. The gyroscope achieves 8/spl deg//sec//spl radic/Hz noise floor, for operation at ambient pressure.
Lower Devonian (Gedinnian) Stromatoporoidea of New York: redescription of the type specimens of Girty (1895) (1988)

Girty (1895) named six species of stromatoporoids from the Lower Devonian of central and east-central New York, which are here redescribed and reillustrated. Additional new specimens provide data on variations within the following species: Anostylostroma jewetti, Parallelostroma foveolatum , ? Parallelostroma centrotum , and ? Parallelostroma microporum.
An Efficient Catalytic Route for the Synthesis of Silane Coupling Agents Based on the 1,1,3,3‐Tetramethyldisiloxane Core (2016)

We report herein the study of the selective mono‐functionalization of 1,1,3,3‐tetramethyldisiloxane (TMDSO) with vinyl‐substituted silicon derivatives through the hydrosilylation reaction. An investigation of the use of platinum‐ and rhodium‐based catalysts in the reactions between TMDSO and exemplary vinyl‐containing silicon derivatives has enabled us to identify the most efficient catalyst, the application of which led to the selective partial functionalization of the disiloxane reagent and the simultaneous formation of only β regioisomers.
Gold hybrid nanoparticles for targeted phototherapy and cancer imaging (2010)

Gold and iron oxide hybrid nanoparticles (HNPs) synthesized by the thermal decomposition technique are bio-functionalized with a single chain antibody, scFv, that binds to the A33 antigen present on colorectal cancer cells. The HNP-scFv conjugates are stable in aqueous solution with a magnetization value of 44 emu g(-1) and exhibit strong optical absorbance at 800 nm. Here we test this material in targeting, imaging and selective thermal killing of colorectal cancer cells. Cellular uptake studies showed that A33-expressing cells take up the A33scFv-conjugated HNPs at a rate five times higher than cells that do not express the A33 antigen. Laser irradiation studies showed that approximately 53% of the A33-expressing cells exposed to targeted HNPs are killed after a six-minute laser treatment at 5.1 W cm(-2) using a 808 nm continuous wave laser diode while < 5% of A33-nonexpressing cells are killed. At a higher intensity, 31.5 W cm(-2), the thermal destruction increases to 99 and 40% for A33-expressing cells and A33 nonexpressing cells, respectively, after 6 min exposure. Flow cytometric analyses of the laser-irradiated A33 antigen-expressing cells show apoptosis-related cell death to be the primary mode of cell death at 5.1 W cm(-2), with increasing necrosis-related cell death at higher laser power. These results suggest that this new class of bio-conjugated hybrid nanoparticles can potentially serve as an effective antigen-targeted photothermal therapeutic agent for cancer treatment as well as a probe for magnetic resonance-based imaging.