gebhart/patrepeval huggingface dataset:
Development of a detachable high speed miniature scanning probe microscope for large area substrates inspection (2015)

We have developed a high speed, miniature scanning probe microscope (MSPM) integrated with a Positioning Unit (PU) for accurately positioning the MSPM on a large substrate. This combination enables simultaneous, parallel operation of many units on a large sample for high throughput measurements. The size of the MSPM is 19 × 45 × 70 mm(3). It contains a one-dimensional flexure stage with counter-balanced actuation for vertical scanning with a bandwidth of 50 kHz and a z-travel range of more than 2 μm. This stage is mechanically decoupled from the rest of the MSPM by suspending it on specific dynamically determined points. The motion of the probe, which is mounted on top of the flexure stage is measured by a very compact optical beam deflection (OBD). Thermal noise spectrum measurements of short cantilevers show a bandwidth of 2 MHz and a noise of less than 15 fm/Hz(1/2). A fast approach and engagement of the probe to the substrate surface have been achieved by integrating a small stepper actuator and direct monitoring of the cantilever response to the approaching surface. The PU has the same width as the MSPM, 45 mm and can position the MSPM to a pre-chosen position within an area of 275×30 mm(2) to within 100 nm accuracy within a few seconds. During scanning, the MSPM is detached from the PU which is essential to eliminate mechanical vibration and drift from the relatively low-resonance frequency and low-stiffness structure of the PU. Although the specific implementation of the MSPM we describe here has been developed as an atomic force microscope, the general architecture is applicable to any form of SPM. This high speed MSPM is now being used in a parallel SPM architecture for inspection and metrology of large samples such as semiconductor wafers and masks.
p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression (2009)

p38alpha MAP kinase is a key anti-inflammatory target for rheumatoid arthritis, influencing biosynthesis of pro-inflammatory cytokines TNFalpha and IL-1beta at a translational and transcriptional level. In this paper, we describe how we have optimized a series of novel p38alpha/beta inhibitors using crystal structures of our inhibitors bound to p38alpha, classical medicinal chemistry, and modeling of virtual libraries to derive a molecule suitable for progression into clinical development.
Vermicelli noodles and their quality assessment (2001)

Production, composition, analysis and packaging of vermicelli-type noodles prepared from wheat and other cereals are reviewed. Aspects considered include: characteristics of European- and Asian-style noodles; cereals used for noodle production (wheat, rice, corn, millet, barley and buckwheat); effects of composition and processing on noodle quality; analytical techniques for assessing quality of noodles; packaging and storage methods; and future developments in vermicelli-type noodle products.
Optical wheel-rotation sensor (1994)

We describe a fiber-optic rotation sensor based on diffraction of light in a magneto-optic crystal (BIG). Exploitation of this effect permits the construction of a sensor requiring no polarization elements or lenses.
Large pitch hollow core honeycomb fiber (2008)

A new kind of hollow core photonic crystal fiber (HC-PCF) for broadband guidance is introduced. Structural and optical properties of a fabricated example are detailed.
Sequencing of the <i>rpoB</i> Gene and Flanking Spacers for Molecular Identification of <i>Acinetobacter</i> Species (2006)

Acinetobacter species are defined on the basis of several phenotypic characters, results of DNA-DNA homology, and more recently, similarities or dissimilarities in 16S rRNA gene sequences. However, the 16S rRNA gene is not polymorphic enough to clearly distinguish all Acinetobacter species. We used an RNA polymerase beta-subunit gene (rpoB)-based identification scheme for the delineation of species within the genus Acinetobacter, and towards that end, we determined the complete rpoB gene and flanking spacer (rplL-rpoB and rpoB-rpoC) sequences of the 17 reference strains of Acinetobacter species and 7 unnamed genomospecies. By using complete gene sequences (4,089 bp), we clearly separated all species and grouped them into different clusters. A phylogenetic tree constructed using these sequences was supported by bootstrap values higher than those obtained with 16S rRNA or the gyrB or recA gene. Four pairs of primers enabled us to amplify and sequence two highly polymorphic partial sequences (350 and 450 bp) of the rpoB gene. These and flanking spacers were designed and tested for rapid identification of the 17 reference strains of Acinetobacter species and 7 unnamed genomospecies. Each of these four variable sequences enabled us to delineate most species. Sequences of at least two polymorphic sequences should be used to distinguish Acinetobacter grimontii, Acinetobacter junii, Acinetobacter baylyi, and genomic species 9 from one another. Finally, 21 clinical isolates of Acinetobacter baumannii were tested for intraspecies relationships and assigned correctly to the same species by comparing the partial sequences of the rpoB gene and its flanking spacers.
Monolithic accelerometer with flexurally mounted force transducer (1993)

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The synthesis of pulse sequences yielding arbitrary magnetization vectors (1989)

A new procedure and algorithm are presented to allow the synthesis of a pulse sequence which will generate an arbitrary frequency-dependent spin excitation. This procedure is a generalization of our previous paper, where this was done subject to the restriction that the spin excitation was symmetric about zero offset frequency, and pulses were restricted to being about a fixed axis. The required final z-magnetization vector (Mz) is expressed as a function of the off-resonance frequency as an Nth order complex Fourier series. We then form a consistent Fourier series for (Mxy). As many as 2(2)N different pulse sequences may be directly generated all of which produce a different Mxy(f), but the same Mz(f). A pulse sequence is then generated which will yield the desired Mz(f) and Mxy(f). This is done by an analytic inversion of the Bloch equation, not by the classical Fourier approximation. This technique enables us to generate any Mz which is potentially realizable by a pulse sequence.
HTTP/2-Based Streaming Solutions for Tiled Omnidirectional Videos (2018)

360° video streaming is coming up against two major technical challenges: network resource consumption and Quality of Experience (QoE). Dynamically adapting the content delivery process to the user behavior is a promising approach to ensure both important network resource savings and satisfying experiences. In this paper, we propose to leverage HTTP Adaptive Streaming (HAS), tiled-based 360° video encoding and the HTTP/2 protocol to implement this dynamic content delivery process. The 360° video stream is spatially encoded into tiles and temporally divided into segments. The client executes two viewport predictions for each segment, one before and one during its delivery. Upon every prediction, it decides on a priority and a quality level for each tile of the video segment; tiles overlapping with the predicted viewport get higher priorities and quality levels. Then it exploits the priority and stream termination features of the HTTP/2 protocol to enforce its decisions. We compare our proposed solution with four alternative schemes on a set of 360° video streaming sessions corresponding to various types of videos, user behaviors and network conditions. Our solution provides better performances: a higher quality on the viewport pixels, a lower ratio of unreceived viewport pixels in bandwidth-constrained networks, and a reduction of the bandwidth consumption, up to 12% compared to the alternative schemes exploiting 2 viewport predictions per video segment.
Sub-mm encapsulated accelerometers: a fully implantable sensor for cochlear implants (2005)

We present, for the first time, a submillimeter sized fully packaged accelerometer as an alternative sensor for use in cochlear implants and middle ear implants. The sensor is as small as 387/spl times/387/spl times/230 /spl mu/m and weighs approximately 100 /spl mu/g. This miniaturization is realized by utilizing an advanced packaging scheme using a thick film encapsulation with epi-polysilicon. The sensor is attached on the middle ear ossicles and measures the vibration transmitted from the tympanic membrane due to the sound in the ear canal. The sensor is fully characterized on a human cadaveric temporal bone preparation.
Novel anti-human Axl monoclonal antibodies for improved patient biomarker studies (2016)

Background: Axl receptor tyrosine kinase has been associated with poor clinical outcome in a wide variety of malignancies including breast, lung, prostate, pancreatic, brain and myeloid cancers. Axl is up-regulated during tumour epithelial-to-mesenchymal transition (EMT) and is associated with metastasis, immune evasion and drug resistance. Methods: The aim of this study was to develop improved assays for detection of Axl protein in patient samples. We developed a panel of mouse monoclonal antibodies directed against the extracellular domain of human Axl, from mice immunized with a recombinant antigen comprising the extracellular domains of human Axl fused to human IgG1 Fc domain. Anti-Axl monoclonal antibodies (MAbs) were assessed for sensitivity, specificity and utility using surface plasmon resonance (SPR) analysis, sandwich enzyme-linked immunosorbent assay (ELISA), Western blot analysis and immunohistochemistry (IHC) staining. Results: One of the anti-human Axl MAb,1H12, performed particularly well, and SPR analysis confirmed both high affinity (50 pM) and high selectivity for Axl versus other Axl-family receptors. In IHC applications on selected human carcinomas and cancer cell line pellets, MAb 1H12 showed improved sensitivity and reduced background staining compared to other members of the MAb panel. A second MAb 5F11 showed very high affinity (5.8 pM) at a non-overlapping epitope and was selected as a partner for 1H12 in sandwich ELISA, producing a highly sensitive and specific assay. Conclusion: MAbs 1H12 and 5F11 represent new anti-human Axl monoclonal antibodies for improved patient biomarker studies.
Integrated Circuit Implementation for a GaN HFET Driver Circuit (2010)

This paper presents the design and implementation of a new integrated circuit (IC) that is suitable for driving the new generation of high-frequency GaN HFETs. The circuit, based upon a resonant switching transition technique, is first briefly described and then discussed in detail, focusing on the design process practical considerations. A new level-shifter topology, used to generate the zero and negative gate-source voltages required to switch the GaN HFET, is introduced and analyzed. The experimental measurements included in this paper report the results of tests carried out on an IC designed and fabricated as part of the multiproject die in high-voltage process H35B4 of Austriamicrosystems. They fully demonstrate the performance of the proposed driver that opens the possibility of fully exploiting the wide capabilities and advantages of GaN devices for use in power electronics applications.
Protocol Discovery from Imperfect Service Interaction Logs (2007)

This paper deals with the problem of discovering protocol models by analyzing real-world interaction logs. There are several scenarios where protocol discovery is useful and needed: (i) In practice, the protocol definition may not be available. This can happen for many reasons, e.g., the service has been developed using a bottom-up approach, by simply SOAP-ifying an existing application; (ii) even when the protocol model is available, protocol discovery is important as we may want to verify if the designed protocol model is what is actually being supported by the implementation and, if not, what are the differences. An instance of this problem involves discovering if the service is compliant with the protocol specification required by some domain-specific standardization body or industry consortium.
Comprehensive eye evaluation algorithm (2016)

In recent years, several research groups have developed automatic algorithms to detect diabetic retinopathy (DR) in individuals with diabetes (DM), using digital retinal images. Studies have indicated that diabetics have 1.5 times the annual risk of developing primary open angle glaucoma (POAG) as do people without DM. Moreover, DM patients have 1.8 times the risk for age-related macular degeneration (AMD). Although numerous investigators are developing automatic DR detection algorithms, there have been few successful efforts to create an automatic algorithm that can detect other ocular diseases, such as POAG and AMD. Consequently, our aim in the current study was to develop a comprehensive eye evaluation algorithm that not only detects DR in retinal images, but also automatically identifies glaucoma suspects and AMD by integrating other personal medical information with the retinal features. The proposed system is fully automatic and provides the likelihood of each of the three eye disease. The system was evaluated in two datasets of 104 and 88 diabetic cases. For each eye, we used two non-mydriatic digital color fundus photographs (macula and optic disc centered) and, when available, information about age, duration of diabetes, cataracts, hypertension, gender, and laboratory data. Our results show that the combination of multimodal features can increase the AUC by up to 5%, 7%, and 8% in the detection of AMD, DR, and glaucoma respectively. Marked improvement was achieved when laboratory results were combined with retinal image features.
SPECT Compton-scattering correction by analysis of energy spectra. (1988)

The hypothesis that energy spectra at individual spatial locations in single photon emission computed tomographic projection images can be analyzed to separate the Compton-scattered component from the unscattered component is tested indirectly. An axially symmetric phantom consisting of a cylinder with a sphere is imaged with either the cylinder or the sphere containing 99mTc. An iterative peak-erosion algorithm and a fitting algorithm are given and employed to analyze the acquired spectra. Adequate separation into an unscattered component and a Compton-scattered component is judged on the basis of filtered-backprojection reconstruction of corrected projections. In the reconstructions, attenuation correction is based on the known geometry and the total attenuation cross section for water. An independent test of the accuracy of separation is not made. For both algorithms, reconstructed slices for the cold-sphere, hot-surround phantom have the correct shape as confirmed by simulation results that take into account the measured dependence of system resolution on depth. For the inverse phantom, a hot sphere in a cold surround, quantitative results with the fitting algorithm are accurate but with a particular number of iterations of the erosion algorithm are less good. (A greater number of iterations would improve the 26% error with the algorithm, however.) These preliminary results encourage us to believe that a method for correcting for Compton-scattering in a wide variety of objects can be found, thus helping to achieve quantitative SPECT.
High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides. (1991)

Five 125I-labeled substituted benzamides, which are close structural analogues of (S)-sulpiride, eticlopride, and isoremoxipride, were evaluated for their selective in vivo uptake into dopamine D2 receptor rich tissue of the rat brain. "Iodopride" (KD 0.88 nM), an iodine substituted benzamide structurally related to sulpiride, displayed a maximal striatum: cerebellar uptake ratio of 7.6. Demonstration of saturation of the receptor with [125I]iodopride in striatum required uptake in frontal cortex to be used, rather than cerebellar uptake, to define nonspecific binding. Two other ligands structurally related to eticlopride, "iclopride" (KD 0.23 nM) and "itopride" (KD 0.16 nM), displayed maximal striatal: cerebellar uptake ratios of 9.8 and 3.3, respectively. The most potent ligands, "epidepride" (KD 0.057 nM) and "ioxipride" (KD 0.070 nM) showed striatal:cerebellar uptake ratios of 234 and 65, respectively. The observed uptake ratios correlated poorly with the affinity constants for the dopamine D2 receptor alone, but were highly correlated (r = 0.92) with the product of the receptor dissociation constant (KD) and the apparent lipophilicity (kw), as determined by reverse-phase HPLC at pH 7.5. Total striatal uptake also appeared dependent on lipophilicity, with maximal uptake occurring for ligands having log kw 2.4-2.8.
Automated text recognition (1993)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1993.
Design and fabrication of novel II-IV semiconductor quantum wire infrared detectors/sensors (2005)

A nanoporous alumina template made from a multilayer metal film structure has been developed that allows for the in situ removal of the electrically insulating alumina barrier layer, exposing a Pt electrode at the pore bases. This barrier free nanoporous system has great potential for DC electrodeposition of a wide variety of materials in the alumina pores. The nanoporous template is fabricated in a more practical way than existing techniques and can be used for the fabrication of nanowires of many materials. Because the template is fabricated directly on the final substrate, no film transfer technique is needed and the substrate can include electrical circuitry. A silicon substrate may be used that provides mechanical stability, facilitates processing, and allows integration with IC components. This will allow for cheap and high efficiency infrared detectors to be fabricated in a practical and cost effective way. The quantum wire devices fabricated in this way can be customized to be used as infrared sensors at a variety of infrared wavelengths.
Power management techniques for control-flow intensive designs (1997)

This paper presents a low-overhead controller-based powermanagement technique that re-specifies control signals to reconfigureexisting multiplexer networks and functional units to minimizeunnecessary activity. We demonstrate that conventional powermanagement techniques may often not be suited to control-flowintensive designs, and provide a comprehensive analysis of thepotential negative effects of power management on circuit delay,glitching activity at control and data path signals, and formationof false combinational cycles. We present techniques to performpower management through controller re-specification while avoidingthe above negative effects, and demonstrate the efficiency ofthe techniques through experiments.
Demonstration of an all-optical quantum controlled-NOT gate (2004)

The promise of tremendous computational power, coupled with the development of robust error-correcting schemes, has fuelled extensive efforts to build a quantum computer. The requirements for realizing such a device are confounding: scalable quantum bits (two-level quantum systems, or qubits) that can be well isolated from the environment, but also initialized, measured and made to undergo controllable interactions to implement a universal set of quantum logic gates. The usual set consists of single qubit rotations and a controlled-NOT (CNOT) gate, which flips the state of a target qubit conditional on the control qubit being in the state 1. Here we report an unambiguous experimental demonstration and comprehensive characterization of quantum CNOT operation in an optical system. We produce all four entangled Bell states as a function of only the input qubits' logical values, for a single operating condition of the gate. The gate is probabilistic (the qubits are destroyed upon failure), but with the addition of linear optical quantum non-demolition measurements, it is equivalent to the CNOT gate required for scalable all-optical quantum computation.
Single-Mode Tunable Quantum Cascade Lasers in the Spectral Range of the CO Laser at - m (2000)

Widely tunable, single-mode quantum cascade dis- tributed feedback (QC-DFB) lasers based on a complex coupling scheme and operating in the wavelength range of the CO laser ( - m) are reported. Dynamic single-mode emission up to high current levels is obtained. The continuous single-mode tuning range is 150 nm, while the tuning range of the equivalent Fabry-Perot laser is nm. By homogeneously reducing all layer thicknesses by 10%, the wavelength coverage of a single QC-laser design can be extended to cover one entire regular band of the fundamental CO laser spectrum. Index Terms—Distributed feedback lasers, mid-infrared, single-mode lasers, tunable lasers, unipolar semiconductor laser.
Effects of Culture Conditions on the Fermentation of Xylose to Ethanol by Candida shehatae (1985)

Summary This research examined four factors on the fermentation of xylose by Candida shehatae, and the following conclusions were reached: (1) A minimal medium is effective for producing ethanol. (2) Peptone and casamino acids stimulate ethanol production. (3) Aeration is important inobtaining good ethanol production rates and yields. (4) The maximal rate ofethanol production is attained around pH 3.2-3.4.Under the best conditions employed, C. shehatae ATCC 22984 produced up to 4% (w/v) ethanol from 20% xylose in four days. With 9% xylose, ethanol yields approximating 0.4 g/g xylose were obtained. Keywords: nitrogen, pH, aeration, sugar concentration, peptone, casamino. INTRODUCTION Efficient utilization of D -xylose should be an integral part of any process for converting angiosperm lignocellulosic residues to ethanol. Even though it is not yet cheap or commercially abundant, xylose comprises a significant fraction of angiosperm hemicellulose, 1 and xylose is much more readily recovered from xylan than is
Inhibition of <i>Mycoplasma pneumoniae</i> Hemadsorption and Adherence to Respiratory Epithelium by Antibodies to a Membrane Protein (1983)

Antiserum and purified immunoglobulin directed against Mycoplasma pneumoniae membrane protein P1 were examined for their influence on mycoplasma viability, metabolism, and cytadsorption. Anti-P1 immunoglobulin inhibited adherence of M. pneumoniae to hamster tracheal rings in vitro by up to 80% and inhibited hemadsorption by greater than 90%. Cytadsorption was also inhibited by anti-P1 Fab fragments. Anti-P1 antibodies had no effect on M. pneumoniae viability or metabolism. The data indicate that anti-P1 antibody obstructs the interaction of M. pneumoniae adhesin P1 with its host receptors.
Madindoline, a Novel Inhibitor of IL-6 Activity from Streptomyces sp. K93-0711. I. Taxonomy, Fermentation, Isolation and Biological Activities. (1996)

Selective growth inhibition against IL-6-dependent cells was detected in fermentation extracts of a microbial strain, K93-0711, which was characterized as Streptomyces species. Active metabolite, termed madindoline A and B, were isolated, and the structure was determined to be 3a-hydroxy-indoline with diketocyclopentene at the N position. Madindoline A and B displayed dose-dependent inhibition of MH60 cells, an IL-6-dependent cell line, in presence of 0.1 U/ml IL-6. The IC50 for madindoline A and B against this cell line was 8 microM and 30 microM, respectively. These compounds did not inhibit the growth of cell lines which are not IL-6 dependent and the growth inhibition of the MH60 cell line was reversed by addition of excess, 0.4 U/ml, of IL-6 to the culture media. These compounds did not show any antimicrobial activity at a concentration of 1,000 micrograms/ml.