gebhart/patrepeval huggingface dataset:
R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. (1995)

The Bcl-2 protein is an important regulator of programmed cell death, but the biochemical mechanism by which this protein prevents apoptosis remains enigmatic. Recently, Bcl-2 has been reported to physically interact with a member of the Ras superfamily of small GTPases, p23-R-Ras. To examine the functional significance of R-Ras for regulation of cell death pathways, the IL-3-dependent cells 32D.3 and FL5.12 were stably transfected with expression plasmids encoding an activated form (38 Glycine-->Valine) of R-Ras protein. R-Ras(38V)-producing 32D.3 and FL5.12 cells experienced increased rates of apoptotic cell death relative to control transfected cells when deprived of IL-3. Analysis of several independent clones of transfected 32D.3 cells revealed a correlation between higher levels of R-Ras protein and faster rates of cell death upon withdrawal of IL-3 from cultures. 32D.3 cells cotransfected with R-Ras(38V) and Bcl-2 exhibited prolonged cell survival in the absence of IL-3, equivalent to 32D.3 cells transfected with Bcl-2 expression plasmids alone. R-Ras(38V) also increased rates of cell death in serum-deprived NIH-3T3 cells, and Bcl-2 again abrogated most of this effect. The ratio of GTP and GDP bound to R-Ras(38V) was not significantly different in control 32D.3 cells vs those that overexpressed Bcl-2, indicating that Bcl-2 does not abrogate R-Ras-mediated effects on cell death by altering R-Ras GDP/GTP regulation. Moreover, purified Bcl-2 protein had no effect on the GTPase activity of recombinant wild-type R-Ras in vitro. When expressed in Sf9 cells using recombinant baculoviruses, R-Ras(38V) bound to and induced activation of Raf-1 kinase irrespective of whether Bcl-2 was coproduced in these cells, suggesting that Bcl-2 does not nullify R-Ras effects by interfering with R-Ras-mediated activation of Raf-1 kinase. Taken together, these findings suggest that R-Ras enhances the activity of a cell death pathway in growth factor-deprived cells and imply that Bcl-2 acts downstream of R-Ras to promote cell survival.
Effective Summarization of Multi-Dimensional Data Streams for Historical Stream Mining (2007)

We consider the following problem: given a very large data stream, a limited space to encode the stream, and a compression technique to compress the stream, retain the most important information from the distant past of the stream while at the same time retain high quality of the compressed information that is in the recent part of the stream to perform temporal analysis of the summarized information. Simple schemes for accumulating micro-clustering summaries of stream windows that have been previously proposed are very ineffective for solving this challenging task. We overcome the limitations of these schemes by first identifying spatial summaries that compress "similar' regions in the data space, and reduce their space consumption using novel approximate spatio-temporal summaries. Second, we present policies for effectively utilizing the space budget and managing these novel approximate spatio-temporal summaries.
Photoluminescence from submicron CaF2:Nd films grown epitaxially on Si(111) and Al(111)/Si(111) (1992)

Nd3+ doped CaF2 films have been grown epitaxially on Si(111) and Al(111)/Si(111) using CaF2 and NdF3 evaporation. Photoluminescence spectra from these samples show high intensity and narrow emission linewidth even when the thickness of the CaF2:Nd films is reduced to 0.2 μm. The 10 457 Å emission line is not quenched until the Nd concentration exceeds 3.8 wt.%. Moreover, while similar spectra are observed, the photoluminescence intensity from the CaF2:Nd films grown on Al/Si(111) is significantly higher than from the CaF2:Nd on Si(111).
Creating reusable well-structured PDF as a sequence of component object graphic (COG) elements (2003)

Portable Document Format (PDF) is a page-oriented, graphically rich format based on PostScript semantics and it is also the format interpreted by the Adobe Acrobat viewers. Although each of the pages in a PDF document is an independent graphic object this property does not necessarily extend to the components (headings, diagrams, paragraphs etc.) within a page. This, in turn, makes the manipulation and extraction of graphic objects on a PDF page into a very difficult and uncertain process.The work described here investigates the advantages of a model wherein PDF pages are created from assemblies of COGs (Component Object Graphics) each with a clearly defined graphic state. The relative positioning of COGs on a PDF page is determined by appropriate 'spacer' objects and a traversal of the tree of COGs and spacers determines the rendering order. The enhanced revisability of PDF documents within the COG model is discussed, together with the application of the model in those contexts which require easy revisability coupled with the ability to maintain and amend PDF document structure.
Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells (2011)

Dendritic cells (DC) are highly specialized antigen-presenting cells characterized by the ability to prime T-cell responses. Mesenchymal stem cells (MSC) are adult stromal progenitor cells displaying immunomodulatory activities including inhibition of DC maturation in vitro. However, the specific impact of MSC on DC functions, upon in vivo administration, has never been elucidated. Here we show that murine MSC impair Toll-like receptor-4 induced activation of DC resulting in the inhibition of cytokines secretion, down-regulation of molecules involved in the migration to the lymph nodes, antigen presentation to CD4(+) T cells, and cross-presentation to CD8(+) T cells. These effects are associated with the inhibition of phosphorylation of intracellular mitogen-activated protein kinases. Intravenous administration of MSC decreased the number of CCR7 and CD49dβ1 expressing CFSE-labeled DC in the draining lymph nodes and hindered local antigen priming of DO11.10 ovalbumin-specific CD4(+) T cells. Upon labeling of DC with technetium-99m hexamethylpropylene amine oxime to follow their in vivo biodistribution, we demonstrated that intravenous injection of MSC blocks, almost instantaneously, the migration of subcutaneously administered ovalbumin-pulsed DC to the draining lymph nodes. These findings indicate that MSC significantly affect DC ability to prime T cells in vivo because of their inability to home to the draining lymph nodes and further confirm MSC potentiality as therapy for immune-mediated diseases.
High-energy and high-peak-power nanosecond pulse generation with beam quality control in 200-µm core highly multimode Yb-doped fiber amplifiers (2005)

We explored high-energy and high-peak-power pulse generation in large-core multimode fiber amplifiers, achieving what is to our knowledge the highest reported energies, up to 82 mJ for 500-ns pulses, 27 mJ for 50-ns pulses, and 2.4-MW peak power for 4-ns pulses at 1064 nm, using 200-microm-diameter and 0.062-N.A. core Yb-doped double-clad fiber amplifiers. The highly multimode nature of the fiber core was mitigated by use of a coiling-induced mode-filtering effect to yield a significant improvement in output-beam quality from M2 = 25 from an uncoiled fiber to M2 = 6.5 from a properly coiled fiber, with the corresponding reduction in number of propagating transverse modes from > or = 200 to < or = 20.
<i>In Vitro</i> Antibacterial Activity of the Ceftazidime-Avibactam Combination against Enterobacteriaceae, Including Strains with Well-Characterized β-Lactamases (2015)

The novel β-lactamase inhibitor avibactam is a potent inhibitor of class A, class C, and some class D enzymes. The in vitro antibacterial activity of the ceftazidime-avibactam combination was determined for a collection of Enterobacteriaceae clinical isolates; this collection was enriched for resistant strains, including strains with characterized serine β-lactamases. The inhibitor was added either at fixed weight ratios to ceftazidime or at fixed concentrations, with the latter type of combination consistently resulting in greater potentiation of antibacterial activity. In the presence of 4 μg/ml of avibactam, the ceftazidime MIC50 and MIC90 (0.25 and 2 μg/ml, respectively) were both below the CLSI breakpoint for ceftazidime. Further comparisons with reference antimicrobial agents were performed using this fixed inhibitor concentration. Against most ceftazidime-susceptible and -nonsusceptible isolates, the addition of avibactam resulted in a significant increase in ceftazidime activity, with MICs generally reduced 256-fold for extended-spectrum β-lactamase (ESBL) producers, 8- to 32-fold for CTX-M producers, and >128-fold for KPC producers. Overall, MICs of a ceftazidime-avibactam combination were significantly lower than those of the comparators piperacillin-tazobactam, cefotaxime, ceftriaxone, and cefepime and similar or superior to those of imipenem.
Endothelium‐dependent and endothelium‐independent vasodilatation of the hepatic artery of the rabbit (1991)

1. The isolated hepatic artery of the rabbit contracted to exogenously applied noradrenaline (NA). There was no significant difference in the maximal contraction or the EC50 value in vessels where the endothelium was present and in endothelium-denuded preparations. 2. Acetylcholine (ACh) induced a vasodilatation of vessels preconstricted with NA which was entirely dependent on the endothelium. 3. Adenosine 5'-triphosphate (ATP), 2-methylthio ATP, adenosine and sodium nitroprusside induced concentration-dependent, sustained relaxations of vessels in which tone had been induced with NA. The relaxation responses were not reduced after removal of the endothelium. 8-Phenyltheophylline antagonized the relaxation response produced by adenosine, but not that due to ATP at lower concentrations. The maximum response to ATP was reduced in the presence of 8-phenyltheophylline. 4. alpha,beta-Methylene ATP produced further contraction of vessels preconstricted with NA in both endothelium-denuded preparations and in vessels where the endothelium remained intact. 5. Immunohistochemical analysis was used to show the presence of nerve fibres containing substance P (SP), calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) in the hepatic artery. Application of SP induced a concentration-dependent relaxation which was entirely dependent on the presence of an intact endothelium. CGRP and VIP, however, elicited concentration-dependent relaxations which were independent of the endothelium. 7. It is concluded that in the rabbit hepatic artery, responses to ACh are dependent on the presence of intact endothelium. P1-, P2x- and P2y-purinoceptors, mediating relaxation to adenosine, vasoconstriction to ATP and vasodilatation to ATP respectively, are located on vascular smooth muscle. Furthermore, CGRP and VIP mediate a direct vasodilatation of smooth muscle both in the absence and the presence of the endothelium, whereas SP produces a relaxation via receptors located on the endothelium.
Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial (2011)

FF doses <800 μg have a favourable therapeutic index. The absence of an efficacy dose response suggests that 200 μg is an appropriate dose in patients with moderate persistent asthma. CLINICALTRIALS.GOV IDENTIFIER: NCT00603746.
Development of a Collagen Hydrogel with High Mechanical Strength by a Simple Orientation Method for Triple-helix (2008)

Abstract Collagen hydrogels with oriented triple-helix were fabricated simply via the axial orientation of a dense collagen solution onto a glass plate and cross-linking. The orientation of the collagen triple-helix in the gels was clearly confirmed by X-ray diffraction measurements. The tensile strength of the oriented collagen gels in parallel was twofold higher than that of non-oriented gels as a control. Our collagen gels with oriented triple-helix can be useful as novel scaffolds in the tissue engineering field.
Symmetry Hierarchy of Man‐Made Objects (2011)

Abstract We introduce symmetry hierarchy of man‐made objects, a high‐level structural representation of a 3D model providing a symmetry‐induced, hierarchical organization of the model's constituent parts. Given an input mesh, we segment it into primitive parts and build an initial graph which encodes inter‐part symmetries and connectivity relations, as well as self‐symmetries in individual parts. The symmetry hierarchy is constructed from the initial graph via recursive graph contraction which either groups parts by symmetry or assembles connected sets of parts. The order of graph contraction is dictated by a set of precedence rules designed primarily to respect the law of symmetry in perceptual grouping and the principle of compactness of representation. We show that symmetry hierarchy naturally implies a hierarchical segmentation that is more meaningful than those produced by local geometric considerations. We also develop an application of symmetry hierarchies for structural shape editing.
Macrophage differentiation and expression of macrophage colony-stimulating factor in murine milky spots and omentum after macrophage elimination (1997)

To elucidate the differentiation mechanisms of macrophages in the murine omentum, we studied the repopulation of these cells and the expression of macrophage colony-stimulating factor (M-CSF) in the milky spots and omental tissues in mice depleted of macrophages following administration of liposome-encapsulated dichloromethylene diphosphonate (clodronate). The macrophages in the omentum were spindle or dendritic in shape, expressed several macrophage-specific antigens and Ia antigen, and phagocytized intraperitoneally injected carbon particles. In the milky spots, macrophages and macrophage precursors were detected, and the number of precursors increased after elimination of macrophages by intraperitoneal injection of liposome-encapsulated clodronate. Macrophage precursors in the milky spots proliferated, moved to the omentum, and transformed into dendritic-shaped macrophages. Expression of M-CSF mRNA extracted from the milky spots was markedly enhanced at 2 and 3 days after macrophage depletion. Localization of M-CSF protein and mRNA was observed in the stromal cells of the milky spots. In osteopetrosis (op/op) mutant mice that are defective in the production of functional M-CSF omental macrophages were absent. These results indicate that M-CSF locally produced in the milky spots plays an important role in providing a microenvironment for development and differentiation of omental macrophages.
PanoDepth: A Two-Stage Approach for Monocular Omnidirectional Depth Estimation (2021)

Omnidirectional 3D information is essential for a wide range of applications such as Virtual Reality, Autonomous Driving, Robotics, etc. In this paper, we propose a novel, model-agnostic, two-stage pipeline for omnidirectional monocular depth estimation. Our proposed framework PanoDepth takes one 360 image as input, produces one or more synthesized views in the first stage, and feeds the original image and the synthesized images into the subsequent stereo matching stage. In the second stage, we propose a differentiable Spherical Warping Layer to handle omnidirectional stereo geometry efficiently and effectively. By utilizing the explicit stereo-based geometric constraints in the stereo matching stage, PanoDepth can generate dense high-quality depth. We conducted extensive experiments and ablation studies to evaluate PanoDepth with both the full pipeline as well as the individual modules in each stage. Our results show that PanoDepth outperforms the state-of-the-art approaches by a large margin for 360 monocular depth estimation. Our code is available at https:// github.com/yuyanli0831/PanoDepth_3dv.
Self-Aligned Organic Light-Emitting Diodes with Color Changing by Ink-Jet Printing Dots (2011)

The self-aligned color-changeing organic light-emitting diodes with the ink-jet printing (IJP) dots have been investigated, and we have studied a device structure of a micro-area color-changeing method involving the IJP emission of dots and their periphery, where a side-coupling emission mode and double-area emission mode were used. The distance of the side-coupling emission from emission dot was estimated to be 10 µm. The brightnesses of the dots and their periphery at 100 mA/cm2 were 1,300 and 380 cd/m2, respectively.
Calculation of left ventricle relative pressure distribution in MRI using acceleration data (2005)

Measurements of pressure variations within the cardiac chambers could provide important information for clinical assessments of cardiovascular function. In this work an MRI method for evaluating spatial distributions of intracardiac relative pressure is presented. We first calculated pressure gradients from MR maps of blood acceleration by applying the NS equation. We then used an original algorithm to compute pressure distribution in a region of interest (ROI) by minimizing the pressure gradient curl so that the result in a given pixel is independent of the integration path. The method was assessed in five healthy volunteers by means of MR 2D maps of the blood acceleration in the left ventricle (LV) during ejection and filling phases. The pressure variations calculated from acceleration mapping fit the known physiological variations better than those based on velocity maps acquired in the same volunteers. Furthermore, the optimization algorithm presented here produced the same results as iterative algorithms proposed by other authors, but in much less time and without requiring adjustable parameters or boundary conditions.
THE EFFECTS OF CONTINUOUS PROGRESS (2016)

While a previous study has shown that requiring a criterion of mastery in a hierarchically related discipline, i. e., Physics, leads to improved transfer (as well as improved acquisition and retention), it is not known whether a greater knowledge of prerequisites in a less hierarchically related discipline, i. e., Religion, leads to improved transfer. The findings reported here which show no dif ferences for transfer as a function of instructional procedure in Religion lead to the conclusion that the learning of prerequisites may have more significant effects on transfer only in the more hierarchically related disciplines. The findings for requiring mastery in a Religion course indicate that acquisition is facilitated in this discipline when the objectives of the course include either analysis and interpretation or factual recall.
Global Consistency Management Methods Based on Escrow Approaches in Mobile ad Hoc Networks (2010)

In a mobile ad hoc network, consistency management of data operations on replicas is a crucial issue for system performance. In our previous work, we classified several primitive consistency levels according to the requirements from applications and provided protocols to realize them. In this paper, we assume special types of applications in which the instances of each data item can be partitioned and propose two consistency management protocols which are combinations of an escrow method and our previously proposed protocols. We also report simulation results to investigate the characteristics of these protocols in a mobile ad hoc network. From the simulation results, we confirm that the protocols proposed in this paper drastically improve data availability and reduce the traffic for data operations while maintaining the global consistency in the entire network.
Building blocks of a flip-chip integrated superconducting quantum processor (2022)

Abstract We have integrated single and coupled superconducting transmon qubits into flip-chip modules. Each module consists of two chips—one quantum chip and one control chip—that are bump-bonded together. We demonstrate time-averaged coherence times exceeding 90 μs, single-qubit gate fidelities exceeding 99.9%, and two-qubit gate fidelities above 98.6%. We also present device design methods and discuss the sensitivity of device parameters to variation in interchip spacing. Notably, the additional flip-chip fabrication steps do not degrade the qubit performance compared to our baseline state-of-the-art in single-chip, planar circuits. This integration technique can be extended to the realisation of quantum processors accommodating hundreds of qubits in one module as it offers adequate input/output wiring access to all qubits and couplers.
A Small Region in HMG I(Y) Is Critical for Cooperation with NF-κB on DNA (1999)

The high mobility group HMG I(Y) protein has been reported to promote the expression of several NF-kappaB-dependent genes by enhancing the binding of NF-kappaB to DNA. The molecular origins of cooperativity in the binding of NF-kappaB and HMG I(Y) to DNA are not well understood. Here we have examined the determinants of specificity in the binding of HMG I(Y), both alone and in cooperation with NF-kappaB, to two different DNA elements, PRDII from the interferon-beta enhancer and IgkappaB from the immunoglobulin kappa light chain enhancer. Of particular interest was the influence of a flanking AT-rich sequence on binding by HMG I(Y). Utilizing yeast one-hybrid screening assays together with alanine-scanning mutagenesis, we have identified mutations of residues in HMG I(Y) that decrease cooperative binding of NF-kappaB to PRDII and IgkappaB sites. These same mutations similarly decreased the binding of HMG I(Y) alone to DNA, and paradoxically, decreased the strength of protein-protein interactions between HMG I(Y) and NF-kappaB. Of the three tandemly repeated basic regions that represent putative DNA-binding motifs in HMG I(Y), the residues within the second repeat are most important for recognition of core NF-kappaB sites, whereas the second and third repeats both appear to be involved in binding to sites that are flanked by AT-rich sequences. Overall, the second repeat of HMG I(Y) is primarily responsible for the stimulatory effect of this protein on the binding of NF-kappaB to PRDII and IgkappaB elements.
Biaryl Axis as a Stereochemical Relay for the Enantioselective Synthesis of Antimicrotubule Agents (2006)

Return to sender: A biaryl configuration that is controlled by a benzylic stereocenter in an atropo-selective Suzuki coupling in turn controls the stereocenter configuration in an SN1-type dehydrative cyclization performed at low temperature. Promising antimicrotubule biaryls of high optical purity are obtained in this manner. TFA=trifluoroacetic acid, pin=pinacolato. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600451_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.