gebhart/patrepeval huggingface dataset:
Novel CoupledCAR technology for treating colorectal cancer. (2020)

e15035 Background: Conventional CAR-T cell therapy has thus far shown weak cell expansion in solid tumor patients and achieved little or no therapeutic responses. Methods: We developed CAR T cells based on a novel CoupledCAR technology to treat solid tumors. We engineered CoupledCAR-T cells with lentiviral vectors encoding an anti- colorectal cancer specific protein CAR molecule, and anti- colorectal cancer specific protein (CRCSP) CAR-T cells showed anti-tumor activities in vitro and in vivo experiments. Further, we conducted several clinical trials for various solid tumors, including two patients with colorectal cancer. After the infusion of CoupledCAR T cells, these two patients showed rapid expansion of CoupledCAR T cells and the killing of tumor cells. Specifically, we observed that CoupledCAR T cells expanded significantly in the patients and infiltrated tumor tissue sites. Results: Both patients achieved PR (Partial Response). Patient Profile: Patient 1: Male, 55Y, Colon Adenocarcinoma. In May 2016, 8 cycles of XELOX chemotherapy and 1 dose of radiotherapy were performed. In Step 2016, “radical rectal resection and terminal ileum double ileostomy” was performed. After surgery, gemcitabine chemotherapy was performed for 2 cycles. In January 2018, relapse and metastasis of prostate and left lung were observed. In April 2019, relapse and metastasis were observed. Patient 2: Female, 57Y, Colon Adenocarcinoma. In December 2014, DT46Gy/2Gy/23 radiotherapy was performed. In December 2014 and January 2015, the single drug chemotherapy of Xeloda was taken orally. In February 2015, laparoscopic radical resection of rectal cancer was performed. In April, May, June, and July 2015, mFOLFOX6 chemotherapy was performed. In June 2019, CT showed tumor metastasis. Observations and Results: Patient 1: One month after infusion (M1), the patient was evaluated as PR; most of the target lesions were significantly reduced by more than 50%, and the primary tumor volume was reduced by ~45%. Patient 2: M1, the patient was also evaluated as PR; the tumor in the left upper lobe tip posterior segment was reduced by approximately 75%. Conclusions: The clinical data demonstrated that CoupledCAR-T cells effectively expanded, infiltrated tumor tissue sites, and kill tumor cells in patients with colorectal cancer. We are recruiting more colorectal cancer patients to further test the safety and efficacy of anti-CRCSP CoupledCAR T cells. Further, since our CoupledCAR technology is a platform technology, we are developing it to treat other solid tumors using different target markers.
Electrode geometry and preferential stimulation of spinal nerve fibers having different orientations: A modeling study (1992)

In a computer modeling study of epidural spinal cord stimulation using a longitudinal array of electrode contacts, the effect of contact geometry and contact combination on the threshold voltages for stimulation of dorsal column (DC) fibers and dorsal root (DR) fibers was investigated. It was concluded that DC-fiber stimulation will be favoured when a tripolar combination and small contact length and spacing are used, while DR-fiber stimulation will be favoured when unipolar stimulation and large contact length are used.
Methylation of the RASSF1A Gene in Human Cancers (2002)

Loss of genetic material from chromosome 3p21.3 is one of the most common and earliest events in the pathogenesis of lung cancer and many other solid tumors. The chromosomal area 3p21.3 is thought to harbor at least one important tumor suppressor gene, which, despite many years of investigation, has remained elusive. In our previous studies, we have identified and cloned a gene from the common homozygous deletion area at 3p21.3. The gene, named RASSF1A (Ras ASSociation domain Family 1A), has homology to a mammalian Ras effector. The RASSF1A gene is epigenetically inactivated in a large percentage of human lung cancers, in particular small cell carcinomas. A high frequency of methylation of RASSF1A is found also in breast cancers, renal cell carcinomas, ovarian, gastric and bladder cancers, and in neuroblastomas. The RASSF1A gene is a candidate for a tumor suppressor gene in 3p21.3.
Liquid crystal waveguides: new devices enabled by >1000 waves of optical phase control (2010)

A new electro-optic waveguide platform, which provides unprecedented voltage control over optical phase delays (> 2mm), with very low loss (< 0.5 dB/cm) and rapid response time (sub millisecond), will be presented. This technology, developed by Vescent Photonics, is based upon a unique liquid-crystal waveguide geometry, which exploits the tremendous electro-optic response of liquid crystals while circumventing their historic limitations. The waveguide geometry provides nematic relaxation speeds in the 10's of microseconds and LC scattering losses that are reduced by orders of magnitude from bulk transmissive LC optics. The exceedingly large optical phase delays accessible with this technology enable the design and construction of a new class of previously unrealizable photonic devices. Examples include: 2-D analog non-mechanical beamsteerers, chip-scale widely tunable lasers, chip-scale Fourier transform spectrometer (< 5 nm resolution demonstrated), widely tunable micro-ring resonators, tunable lenses, ultra-low power (< 5 microWatts) optical switches, true optical time delay devices for phased array antennas, and many more. All of these devices may benefit from established manufacturing technologies and ultimately may be as inexpensive as a calculator display. Furthermore, this new integrated photonic architecture has applications in a wide array of commercial and defense markets including: remote sensing, micro-LADAR, OCT, FSO, laser illumination, phased array radar, etc. Performance attributes of several example devices and application data will be presented. In particular, we will present a non-mechanical beamsteerer that steers light in both the horizontal and vertical dimensions.
Virtual-Source Modeling of N-polar GaN MISHEMTS (2019)

Nitrogen-polar (N-polar) Gallium Nitride (GaN) deep-recess high-electron mobility transistors (HEMTs) have demonstrated exceptional power density (8 W/mm) and high efficiency at 30 and 94 GHz. Unlike the conventional Galliumpolar GaN which have typical Silicon Nitride passivation, the Npolar deep-recess structure has a GaN cap layer added in the access region of the transistor to enhance the conductivity while reducing the DC-to-RF dispersion. Previously, the MIT virtual source (VS) model has been proposed as a physics-based approach to modeling Ga-polar devices. This work investigates the application of the VS model to N-polar GaN HEMTs. We present a comparison of DC-IV between the developed model and a fabricated device to demonstrate good agreement.
Robust power optimization for device-to-device communication in a multi-cell network under partial CSI (2017)

For device-to-device (D2D) underlaid cellular networks, the perfect channel state information (CSI) may not be available at the base station (BS). In this work, under an assumption of partial CSI, we study the problem of maximizing the expected sum rate for a cellular user (CU) and a D2D pair, with receive beamforming at the BS, subject to minimum SINR requirements for both the CU and D2D pair, per-node maximum power, and inter-cell interference constraints in multiple neighboring cells. We solve this non-convex joint optimization problem in two steps. We first consider the D2D admissibility problem to determine whether the D2D pair can reuse the channel resource of the CU. We then propose a robust power control algorithm using a ratio-of-expectation approximation to maximize the expected sum rate. For benchmarking, we further provide an upper bound on the maximum expected sum rate. Simulation results show that our proposed solution gives performance close to the upper bound.
Zirconia–Silica–Carbon Coatings on Ceramic Fibers (2004)

Precursors for zircon–carbon mixtures were made to coat fibers for ceramic‐matrix composites. Precursors were characterized using XRD, TGA, and DTA. Zircon formed from vanadium‐ or lithium‐doped precursors after heat treatments at ≥900°C in air, but it did not form at 1200°–1400°C in argon when large amounts of carbon were added. Some precursors were used to coat Nextel™ 720 and Hi‐Nicalon™ fibers. The coatings were characterized using SEM and TEM, and coated‐fiber tensile strengths were measured. Although zircon formed in powders, only tetragonal‐zirconia–silica mixed phases formed in fiber coatings at 1200°C in air. Loss of vanadium oxide flux to the fibers may have caused the lack of conversion to zircon. The strengths of the coated fibers were severely degraded after heat treatment at ≥1000°C in air, but not in argon. The coated fibers were compared with zirconia–carbon‐coated fibers made using similar methods. Mechanisms for fiber strength degradation are discussed.
C-Terminal DxD-Containing Sequences within Paramyxovirus Nucleocapsid Proteins Determine Matrix Protein Compatibility and Can Direct Foreign Proteins into Budding Particles (2016)

Paramyxoviruses are responsible for a wide range of diseases that affect both humans and animals. Paramyxovirus pathogens include measles virus, mumps virus, human respiratory syncytial virus, and the zoonotic paramyxoviruses Nipah virus and Hendra virus. Infectivity of paramyxovirus particles depends on matrix-nucleocapsid protein interactions which enable efficient packaging of encapsidated viral RNA genomes into budding virions. In this study, we have defined regions near the C-terminal ends of paramyxovirus nucleocapsid proteins that are important for matrix protein interaction and that are sufficient to direct a foreign protein into budding particles. These results advance our basic understanding of paramyxovirus genome packaging interactions and also have implications for the potential use of virus-like particles as protein delivery tools.
New industrial fluoropolymer science and technology (1995)

Abstract Teflon® AF, a family of copolymers of perfluoro‐2,2‐dimethyldioxole with tetrafluoroethylene, and Cytop®, a ring‐cyclized homopolymer of CF 2 =CFO(CF 2 ) 2 CF=CF 2 are the first commercial amorphous perfluoroplastics which combine high optical clarity and solubility with outstanding chemical, thermal and electrical properties. The processes for making these materials are described and recent structure‐property studies that reveal dramatic substituent effects on polymer T g and related properties are reviewed. The results of some initial fundamental kinetic studies on fluorinated free‐radical cyclizations that relate to efficient cyclopolymerization of fluorinated dienes and the design of new ring‐containing fluoroplastics are discussed.
Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe): A new radiomics descriptor (2016)

In this paper, we introduce a new radiomic descriptor, Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe) for capturing subtle differences between benign and pathologic phenotypes which may be visually indistinguishable on routine anatomic imaging. CoLlAGe seeks to capture and exploit local anisotropic differences in voxel-level gradient orientations to distinguish similar appearing phenotypes. CoLlAGe involves assigning every image voxel an entropy value associated with the co-occurrence matrix of gradient orientations computed around every voxel. The hypothesis behind CoLlAGe is that benign and pathologic phenotypes even though they may appear similar on anatomic imaging, will differ in their local entropy patterns, in turn reflecting subtle local differences in tissue microarchitecture. We demonstrate CoLlAGe's utility in three clinically challenging classification problems: distinguishing (1) radiation necrosis, a benign yet confounding effect of radiation treatment, from recurrent tumors on T1-w MRI in 42 brain tumor patients, (2) different molecular sub-types of breast cancer on DCE-MRI in 65 studies and (3) non-small cell lung cancer (adenocarcinomas) from benign fungal infection (granulomas) on 120 non-contrast CT studies. For each of these classification problems, CoLlAGE in conjunction with a random forest classifier outperformed state of the art radiomic descriptors (Haralick, Gabor, Histogram of Gradient Orientations).
Production of Human papillomavirus pseudovirions in plants and their use in pseudovirion-based neutralisation assays in mammalian cells (2016)

Human papillomaviruses (HPV) cause cervical cancer and have recently also been implicated in mouth, laryngeal and anogenital cancers. There are three commercially available prophylactic vaccines that show good efficacy; however, efforts to develop second-generation vaccines that are more affordable, stable and elicit a wider spectrum of cross-neutralising immunity are still ongoing. Testing antisera elicited by current and candidate HPV vaccines for neutralizing antibodies is done using a HPV pseudovirion (PsV)-based neutralisation assay (PBNA). PsVs are produced by transfection of mammalian cell cultures with plasmids expressing L1 and L2 capsid proteins, and a reporter gene plasmid, a highly expensive process. We investigated making HPV-16 PsVs in plants, in order to develop a cheaper alternative. The secreted embryonic alkaline phosphatase (SEAP) reporter gene and promoter were cloned into a geminivirus-derived plant expression vector, in order to produce circular dsDNA replicons. This was co-introduced into Nicotiana benthamiana plants with vectors expressing L1 and L2 via agroinfiltration, and presumptive PsVs were purified. The PsVs contained DNA, and could be successfully used for PBNA with anti-HPV antibodies. This is the first demonstration of the production of mammalian pseudovirions in plants, and the first demonstration of the potential of plants to make DNA vaccines.
Magnetic force microscopy study of the thermal stability of perpendicular magnetic recording media (2003)

Summary form only given. Perpendicular recording is believed to be one of the most promising candidates for the future generations of hard drives, because perpendicular recording is technically close to conventional longitudinal recording while it addresses the critical issue of thermal stability. A magnetic force microscopy (MFM) study of the data stability in a double-layer perpendicular magnetic recording medium is presented. Autocorrelation signal-to-noise ratio (ACSN) and more conventional signal-to-noise ratio (SNR) analysis were used in conjunction with MFM to characterize the integral noise characteristics of the written tracks. Transition noise, DC noise, and percolation effects were also studied to provide more detailed information on various sources of noise. Two types of media were investigated: CoCr-alloy based with relatively low remanent squareness of 0.7 and coercivity of 3.5 kOe and a Co/Pd based multilayer with remanent squareness of 1, coercivity field of 7 kOe and nucleation field of 3 kOe.
Design and Evaluation of a Portable Laparoscopic Training System Using Virtual Reality (2016)

The ubiquitous nature of laparoscopic surgery and the decreased training time available for surgeons are driving an increased need for effective training systems to help surgeons learn different procedures. A cost-effective and user-friendly simulator has been designed to imitate specific training tasks for laparoscopic surgery in virtual environments via image processing and computer vision. The capability of using various actual surgical instruments suited for these specific procedures gives heightened fidelity to the simulator. Image processing via matlab software provides real-time mapping of the graspers in the workspace to the virtual reality (VR) environment (vizard software). Two different tasks (peg transfer and needle passing) were designed to evaluate trainees and compare their performance with characteristics of expert surgeons. Pilot testing of the system was carried out with 11 subjects to validate the similarity of this device with an existing surgical box trainer. Task completion time and muscle activity have been used as metrics for evaluation. The decrease in completion time for all subjects suggests similarity of skills transfer for both simulators. In addition, the p-value of muscle activity showed no significant differences for most muscles in the peg transfer task when using either the VR or physical analog environment and no significant differences for about half of the muscles in the needle passing task. Based on the results, the new proposed VR simulator appears to be a viable alternative to help trainees gain laparoscopic skills.
Sulfoxaflor and the sulfoximine insecticides: Chemistry, mode of action and basis for efficacy on resistant insects (2013)

The sulfoximines, as exemplified by sulfoxaflor ([N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ(4)-sulfanylidene] cyanamide] represent a new class of insecticides. Sulfoxaflor exhibits a high degree of efficacy against a wide range of sap-feeding insects, including those resistant to neonicotinoids and other insecticides. Sulfoxaflor is an agonist at insect nicotinic acetylcholine receptors (nAChRs) and functions in a manner distinct from other insecticides acting at nAChRs. The sulfoximines also exhibit structure activity relationships (SAR) that are different from other nAChR agonists such as the neonicotinoids. This review summarizes the sulfoximine SAR, mode of action and the biochemistry underlying the observed efficacy on resistant insect pests, with a particular focus on sulfoxaflor.
Successful Treatment of Hyperuricosuric Calcium Oxalate Nephrolithiasis with Potassium Citrate (1986)

No AccessJournal of UrologyCalculus1 Oct 1986Successful Treatment of Hyperuricosuric Calcium Oxalate Nephrolithiasis with Potassium Citrate C.Y.C. Pak, and R. Peterson C.Y.C. PakC.Y.C. Pak More articles by this author , and R. PetersonR. Peterson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)45157-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Successful Treatment of Hyperuricosuric Calcium Oxalate Nephrolithiasis with Potassium Citrate." The Journal of Urology, 136(4), p. 980 © 1986 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 136Issue 4October 1986Page: 980 Advertisement Copyright & Permissions© 1986 by The American Urological Association Education and Research, Inc.MetricsAuthor Information C.Y.C. Pak More articles by this author R. Peterson More articles by this author Expand All Advertisement PDF DownloadLoading ...
A speech understanding framework that uses multiple language models and multiple understanding models (2009)

The optimal combination of language model (LM) and language understanding model (LUM) varies depending on available training data and utterances to be handled. Usually, a lot of effort and time are needed to find the optimal combination. Instead, we have designed and developed a new framework that uses multiple LMs and LUMs to improve speech understanding accuracy under various situations. As one implementation of the framework, we have developed a method for selecting the most appropriate speech understanding result from several candidates. We use two LMs and three LUMs, and thus obtain six combinations of them. We empirically show that our method improves speech understanding accuracy. The performance of the oracle selection suggests further potential improvements in our system.
Liposome flow injection immunoassay: model calculations of competitive immunoreactions involving univalent and multivalent ligands (1991)

The use of liposomes as detectable reagents in solid-phase immunoassays has been explored in a flow injection immunoanalysis (FIIA) system. Model calculations are presented for FIIA based on the competitive binding of univalent analyte and multivalent liposomes to immobilized antibodies. Parameters such as binding constants, concentrations of liposomes and antibody, and steric hindrance are considered for their relative effects on detectable liposome signal response to analyte concentrations. Qualitative comparisons of the model with the experimental data are made.
The protease inhibitor, Bowman-Birk Inhibitor, suppresses experimental autoimmune encephalomyelitis: a potential oral therapy for multiple sclerosis (2006)

Available treatments for multiple sclerosis (MS) require frequent injections and have significant side effects. Proteases generated during inflammation are involved in the induction of tissue damage during inflammatory demyelination in the central nervous system (CNS). The Bowman-Birk Inhibitor (BBI), a soy-derived protease inhibitor with anti-carcinogenic and anti-inflammatory properties, has been shown to be well tolerated in clinical trials for pre-cancerous conditions, such as oral leukoplakia and the inflammatory disease, ulcerative colitis. We hypothesized that BBI may modulate experimental autoimmune encephalomyelitis (EAE), an animal model of MS. The BBI concentrate (BBIC), a soybean extract enriched in BBI, was administered to myelin basic protein (MBP)-immunized Lewis rats by gastric gavage in different treatment regimens, during the induction or the effector phase of disease. BBIC significantly delayed disease onset and suppressed disease severity, clinically and pathologically, in all treatment protocols. Both in vitro and ex vivo, BBIC inhibited MBP-specific proliferation of lymph node cells. BBIC reduced the activity of matrix metalloproteinase (MMP)-2 and -9 in spleen cell supernatants and was detected in the CNS of treated rats. BBIC suppresses EAE, it can be administered orally, and it is safe and relatively inexpensive. It may have a therapeutic role in patients with MS.
Using an Engineered Galvanic Redox System to Generate Positive Surface Potentials that Promote Osteogenic Functions (2018)

Successful osseointegration of orthopaedic and orthodontic implants is dependent on a competition between osteogenesis and bacterial contamination on the implant-tissue interface. Previously, by taking advantage of the highly interactive capabilities of silver nanoparticles (AgNPs), we effectively introduced an antimicrobial effect to metal implant materials using an AgNP/poly(dl-lactic- co-glycolic acid) (PLGA) coating. Although electrical forces have been shown to promote osteogenesis, creating practical materials and devices capable of harnessing these forces to induce bone regeneration remains challenging. Here, we applied galvanic reduction-oxidation (redox) principles to engineer a nanoscale galvanic redox system between AgNPs and 316L stainless steel alloy (316L-SA). Characterized by scanning electron microscopy , energy-dispersive X-ray spectroscopy, atomic force microscopy, Kelvin probe force microscopy, and contact angle measurement, the surface properties of the yield AgNP/PLGA-coated 316L-SA (SNPSA) material presented a significantly increased positive surface potential, hydrophilicity, surface fractional polarity, and surface electron accepting/donating index. Importantly, in addition to its bactericidal property, SNPSA's surface demonstrated a novel osteogenic bioactivity by promoting peri-implant bone growth. This is the first report describing the conversion of a normally deleterious galvanic redox reaction into a biologically beneficial function on a biomedical metal material. Overall, this study details an innovative strategy to design multifunctional biomaterials using a controlled galvanic redox reaction, which has broad applications in material development and clinical practice.