gebhart/patrepeval huggingface dataset:
Real-Time Implementation of a Seven-Level Packed U-Cell Inverter with a Low-Switching-Frequency Voltage Regulator (2015)

In this paper, a new cascaded nonlinear controller has been designed and implemented on the packed U-cell (PUC) seven-level inverter. The proposed controller has been designed based on a simplified model of PUC inverter and consists of a voltage controller as an outer loop and a current controller as an inner loop. The outer loop regulates the PUC inverter capacitor voltage as the second dc bus. The inner loop is in charge of controlling the flowing current, which is also used to charge and discharge that capacitor. The main goal of the whole system is to keep the dc capacitor voltage at a certain level results in generating a smooth and quasi-sine-wave seven-level voltage waveform at the output of the inverter with low switching frequency. The proposed controller performance is verified through experimental tests. Practical results prove the good dynamic performance of the controller in fixing the PUC capacitor voltage for various and variable load conditions and yet generating low-harmonic seven-level voltage waveform to deliver power to the loads. Operation as an uninterruptible power supply (UPS) or ac loads interface for photovoltaic energy conversion applications is targeted.
Learning to Achieve Goals (1993)

Temporal difference methods solve the temporal credit assignment problem for reinforcement learning. An important subproblem of general reinforcement learning is learning to achieve dynamic goals. Although existing temporal difference methods, such as Q learning, can be applied to this problem, they do not take advantage of its special structure. This paper presents the DG-learning algorithm, which learns efficiently to achieve dynamically changing goals and exhibits good knowledge transfer between goals. In addition, this paper shows how traditional relaxation techniques can be applied to the problem. Finally, experimental results are given that demonstrate the superiority of DG learning over Q learning in a moderately large, synthetic, non-deterministic domain.
A new strategy for the synthesis of homologously pure linear polystannane oligomers (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new strategy for the synthesis of homologously pure linear polystannane oligomersLawrence R. SitaCite this: Organometallics 1992, 11, 4, 1442–1444Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/om00040a007https://doi.org/10.1021/om00040a007research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Multichannel Biotelemetry Transmitter Utilizing a PCM Subcarrier (2015)

Making use of the currently available integrated circuits, a miniature PCM telemetry system operating from one miniature 9-volt battery and drawing less than 5 milliamps has been constructed. The use of this PCM telemetry signal not only provides accurate data transmission, but requires a minimum of RF bandwidth. The serial format that results from multiplexing the input data allows the use of a single channel recorder with its cost savings over a multichannel tape recorder. An additional benefit of the PCM encoding is that the data is in digital format and is directly suitable for computer use.
Reducing Environmental Impact: Solvent and PEO Reclamation During Production of Melt-Extruded PCL Nanofibers (2015)

An improved subtractive manufacturing process for fabrication of rectangular, high-surface-area poly(ε-caprolactone) (PCL) fibers is presented. PCL fibers were derived from continuous coextruded tapes of poly(ethylene oxide) (PEO)/PCL with 75% reduction in washing time, while still achieving >99 wt % PCL purity with a quantitative yield of PCL fibers. The fabricated PCL fiber mat had a measured surface area of 3.27 ± 0.53 m2/g. A two-stage distillation process was used to recover methanol and water used in composite solvation to remove PEO. Both methanol and water were recovered at ∼100% purity with a fractional recovery of 87 ± 2% and 95 ± 2%, respectively. Solvated PEO was also recovered at a fractional recovery of 94 ± 4% at ∼100% purity. Gel permeation chromatography and thermal analysis revealed no chain scission, thermal degradation, or cross-linking within the recovered PEO, which suggested the possibility of reincorporating recovered PEO to the multilayer coextrusion process for future composite coextrusion. These waste reduction figures represent recovery on the laboratory-scale process with substantial room for improvement in a fully automated, large-scale industrial process. By reducing overall waste generation >90%, fibers derived from multilayer coextrusion may become an industrially viable alternative for nanofiber manufacturing.
Managing a large outbreak of cryptosporidiosis: how to investigate and when to decide to lift a 'boil water' notice. (2002)

The largest outbreak of cryptosporidiosis reported in the United Kingdom, involving 575 confirmed cases (of which 474 met an agreed case definition), occurred in the county of Devon during August and September of 1995. The descriptive epidemiology supports the hypothesis that the outbreak was associated with the consumption of cold tap water in the area served by a particular water treatment works. Cryptosporidium oocysts were detected in treated water samples at the time of the outbreak. Although the epidemiological analysis provided strong circumstantial evidence of a waterborne outbreak, the data were not recorded in a manner that made them admissible in criminal proceedings taken by the Drinking Water Inspectorate against the water company involved. The need to carry out an analytical study in conjunction with the identification and characterisation of the pathogen in the drinking water and the practicalities of agreeing criteria for lifting a 'boil water' notice are discussed.
[Evaluation of comatose states]. (1986)

The most informative neurological symptoms allowing the differentiation of 7 phases of consciousness disorders have been identified on the basis of clinico-physiological correlations and mathematical processing. In the first phase of coma the patient cannot be waken up. Addition of muscle atonia characterizes the transfer to the second phase of coma and of bilateral mydriasis indicates the transfer to the third phase. Eye opening in response to sound or pain points to awakening and transfer to the phase of apallitic syndrome. The performance of simple instructions is characteristic of the phase of deep stupor. Responses to questions characterize stupor, and recovery of orientation in the environment indicates clear consciousness.
Bioavailable copper modulates oxidative phosphorylation and growth of tumors (2013)

Copper is an essential trace element, the imbalances of which are associated with various pathological conditions, including cancer, albeit via largely undefined molecular and cellular mechanisms. Here we provide evidence that levels of bioavailable copper modulate tumor growth. Chronic exposure to elevated levels of copper in drinking water, corresponding to the maximum allowed in public water supplies, stimulated proliferation of cancer cells and de novo pancreatic tumor growth in mice. Conversely, reducing systemic copper levels with a chelating drug, clinically used to treat copper disorders, impaired both. Under such copper limitation, tumors displayed decreased activity of the copper-binding mitochondrial enzyme cytochrome c oxidase and reduced ATP levels, despite enhanced glycolysis, which was not accompanied by increased invasiveness of tumors. The antiproliferative effect of copper chelation was enhanced when combined with inhibitors of glycolysis. Interestingly, larger tumors contained less copper than smaller tumors and exhibited comparatively lower activity of cytochrome c oxidase and increased glucose uptake. These results establish copper as a tumor promoter and reveal that varying levels of copper serves to regulate oxidative phosphorylation in rapidly proliferating cancer cells inside solid tumors. Thus, activation of glycolysis in tumors may in part reflect insufficient copper bioavailability in the tumor microenvironment.
<i>Staphylococcus aureus</i><i>agr</i>and<i>sarA</i>Functions Are Required for Invasive Infection but Not Inflammatory Responses in the Lung (2002)

Staphylococcus aureus strains lacking agr- and sarA-dependent gene products or specific MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesins were compared for the ability to activate inflammatory responses in the lung. The mutants were evaluated for virulence in a mouse model of pneumonia and by quantifying their ability to stimulate interleukin-8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in respiratory epithelial cells. In a neonatal mouse, only strains with intact agr and sarA loci were consistently associated with invasive, fatal pulmonary infection (P < 0.001) and sarA was specifically required to cause bacteremia (P < 0.001). The agr and/or sarA mutants were, nonetheless, fully capable of producing pneumonia and were as proficient as the wild-type strain in stimulating epithelial IL-8 expression, a polymorphonuclear leukocyte chemokine, in airway cells. In contrast, agr and especially sarA mutants induced less epithelial GM-CSF expression, and MSCRAMM mutants lacking fibronectin binding proteins or clumping factor A, a ligand for fibrinogen, were unable to stimulate epithelial GM-CSF production. The ability to induce IL-8 expression was independent of the adherence properties of intact bacteria, indicating that shed and/or secreted bacterial components activate epithelial responses. While conserved staphylococcal components such as peptidoglycan are sufficient to evoke inflammation and cause pneumonia, the agr and sarA loci of S. aureus are critical for the coordination of invasive infection of the lungs.
Design of a highly parallel AI processor using new multiple-valued MOS devices (1988)

A design for a highly parallel processor for real-time reasoning in artificial intelligence (AI) is presented. Knowledge is represented by an associative network based on multiple-valued logic, so that a universal representation can be achieved by varying the parameters between nodes. High-speed reasoning can be attributed to the parallel graph-search technique on this associative network. For its direct implementation, special MOS devices with threshold voltages that are controllable by the external input signals are used. For the four-valued associative network, it is demonstrated that the number of memory cells, cell interconnections, and transistors can be greatly reduced in comparison with the corresponding binary implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Geographic Data Processing (1979)

article Free Access Share on Geographic Data Processing Authors: George Nagy University of Nebraska-Lincoln University of Nebraska-LincolnView Profile , Sharad Wagle Department of Computer Science, Illinois Institute of Technology, Chicago, Illinois and University of Nebraska-Lincoln Department of Computer Science, Illinois Institute of Technology, Chicago, Illinois and University of Nebraska-LincolnView Profile Authors Info & Claims ACM Computing SurveysVolume 11Issue 2June 1979 pp 139–181https://doi.org/10.1145/356770.356777Published:01 June 1979Publication History 100citation2,726DownloadsMetricsTotal Citations100Total Downloads2,726Last 12 Months101Last 6 weeks20 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Novel Seco Cyclopropa[<i>c</i>]pyrrolo[3,2-<i>e</i>]indole Bisalkylators Bearing a 3,3‘-Arylenebisacryloyl Group as a Linker (2001)

We synthesized the novel seco cyclopropa[c]pyrrolo[3,2-e]indole (CPI) bisalkylators and evaluated their antitumor activity. Among these derivatives, 11a (AT-760), in which the two seco 3-methoxycarbonyl-2-trifluoromethyl CPI (MCTFCPI) moieties are connected with a 3,3'-(1,4-phenylene)bisacryloyl group, was found to exhibit more potent cytotoxicity and antitumor activity against HeLaS3 human uterine cervix carcinoma cells and Colon 26 adenocarcinoma cells, respectively, than 8 (bizelesin, U-77,779). It also appeared that compound 11a exhibits improved in vivo efficacy in the human colon CX-1 model when compared to either compound 8 or mitomycin C (MMC). Efficacious doses for 11a were found to be 2-fold lower than those for 8.
35-GHz-Doppler radar for law enforcement agencies in Europe (2003)

An experimental program was conducted to investigate the reflectivity of moving motor vehicles using a Ka-band CW Doppler radar, as well as the accuracy of speed measurements as a function of parameters such as antenna polarization, beam illumination, side distance, multipath, antenna height, signal-to-interference ratio, and aspect angle. The experimental setup used a stationary dual-channel 35-GHz CW Doppler radar with selectable transmit polarization, direction-of-motion-sensing capability, and a signal recording system. The results of the experiments provide basic data for the design of law-enforcement radars at Ka-band. The dominant scatterers and their location on the vehicle were determined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment (2018)

Dementia with Lewy bodies is one of the most common causes of dementia. It is not as common as Alzheimer's disease; the general public's awareness of the disease is poor in comparison. Its effects on caregivers and patients alike are not well known to the general population. There are currently no FDA-approved medications specifically for the treatment of DLB. Many of the medications that are approved for Alzheimer's disease are widely used in the treatment of DLB with varying degrees of success. Treatment of DLB is life long and requires a dedicated team of physicians and caregivers to minimize the degree of morbidity and mortality experienced by the patients suffering from the disease as it progresses.
LD redundancy system using polarization components for a submarine optical transmission system (1984)

An LD redundancy system having one cold standby laser diode is proposed to improve reliability in submarine optical transmission systems. This system makes use of the intrinsic laser polarization and consists of two LD modules and a polarization coupler connected by polarization maintaining (PANDA) fibers. The optical power insertion loss of this LD redundant system is 5.5 dB, including coupling loss between the laser diode and PANDA fiber. This LD redundant system will be applied in submarine optical repeaters.
p110β Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity (2000)

Activation of p85/p110 type phosphatidylinositol kinase is essential for aspects of insulin-induced glucose metabolism, including translocation of GLUT4 to the cell surface and glycogen synthesis. The enzyme exists as a heterodimer containing a regulatory subunit (e.g. p85alpha) and one of two widely distributed isoforms of the p110 catalytic subunit: p110alpha or p110beta. In the present study, we compared the two isoforms in the regulation of insulin action. During differentiation of 3T3-L1 cells into adipocytes, p110beta was up-regulated approximately 10-fold, whereas expression of p110alpha was unaltered. The effects of the increased p110 expression were further assessed by expressing epitope tagged p110beta and p110alpha in 3T3-L1 cells using adenovirus transduction systems, respectively. In vitro, the basal lipid kinase activity of p110beta was lower than that of p110alpha. When p110alpha and p110beta were overexpressed in 3T3-L1 adipocytes, exposing cells to insulin induced each of the subunits to form complexes with p85alpha and tyrosine-phosphorylated IRS-1 with similar efficiency. However, whereas the kinase activity of p110beta, either endogenous or exogeneous, was markedly enhanced by insulin stimulation, only very small increases of the activity of p110alpha were observed. Interestingly, overexpression of p110beta increased insulin-induced glucose uptake by 3T3-L1 cells without significantly affecting basal glucose transport, whereas overexpression of p110alpha increased both basal and insulin-stimulated glucose uptake. Finally, microinjection of anti-p110beta neutralizing antibody into 3T3-L1 adipocytes abolished insulin-induced translocation of GLUT4 to the cell surface almost completely, whereas anti-p110alpha neutralizing antibody did only slightly. Together, these findings suggest that p110beta plays a crucial role in cellular activities evoked acutely by insulin.
The role of iron in erythropoiesis in the absence and presence of erythropoietin therapy (2002)

Preoperative autologous blood donation has served as a model for blood loss anaemia. Studies in these patients, along with clinical trials of i.v. iron and recombinant human erythropoietin (rHuEPO) therapy, have furthered our understanding of the relationship between erythropoietin, iron, and erythropoiesis. With supplemental oral iron, the endogenous erythropoietic response to routine autologous blood donation and to the anaemia of chronic illness has been shown to be modest, but predictable. In more aggressive donation and more severe anaemia, the endogenous erythropoietic response is more substantial, but still predictable. Studies in patients undergoing aggressive phlebotomy whilst receiving rHuEPO demonstrate a wide variation in response to rHuEPO dose. This variability is not related to age or gender and suggests factors such as iron-restricted erythropoiesis may be responsible. Supporting evidence arises from the superior erythropoietic response observed in patients with haemochromatosis. These patients maintain very high serum iron and transferrin saturation levels. In response to serial phlebotomy these patients can mount an endogenous erythropoietin response up to five-times greater than healthy individuals. When treated with rHuEPO, patients with haemochromatosis respond with much greater RBC expansion volumes than patients receiving rHuEPO and iron supplementation. Studies show no difference in the degree of endogenously stimulated erythropoiesis between patients with measurable iron stores and those without. However, when treated with rHuEPO, increased erythropoiesis has been observed in patients with measurable iron stores compared with those without. This suggests that, while oral iron supplementation may be sufficient to keep pace with endogenously stimulated erythropoiesis, it may not be adequate to prevent iron-restricted erythropoiesis during rHuEPO therapy. Some studies have suggested that i.v iron may prevent iron-restricted erythropoiesis during rHuEPO therapy although further research is needed. The availability of better tolerated i.v. iron preparations provides an ideal opportunity to study the value of iron therapy in patients with acute blood loss, particularly those undergoing rHuEPO therapy.
Characteristics of cultured human melanocytes isolated from different stages of tumor progression. (1985)

Normal melanocytes and melanocytes of normal nevi, primary melanoma in the radial (RGP) and vertical (VGP) growth phases, and metastatic melanoma exhibited and maintained phenotypic differences when grown in tissue culture or in experimental animals. Only metastatic and VGP primary melanoma cells were tumorigenic in athymic nude mice and had nonrandom chromosomal abnormalities involving chromosomes 1, 6, and 7. The colony-forming efficiency in soft agar was also highest in these two cell types. A cell line of RGP primary melanoma had characteristics of both benign and malignant cells: nevus-like morphology; nontumorigenicity in nude mice; but karyotypic abnormality of chromosome 6. It also had a ganglioside pattern similar to that of normal melanocytes but not melanomas, i.e., a high GM3 ganglioside content compared to the amounts of GM2, GD2, and GD3 gangliosides. Binding of monoclonal antibodies secreted by hybridomas generated by immunization of mice with VGP primary and metastatic melanoma was highest with cells and supernatants of cultures from advanced melanoma and least with nevus cells. There was no binding to normal melanocytes except with the monoclonal antibodies specific for nerve growth factor receptor or 9-O-acetyl-GD3 ganglioside. On the other hand, monoclonal anti-nevus antibodies bound to melanocytes, nevus cells, and RGP primary melanoma cells but not to VGP primary or metastatic melanoma cells. Cultured human melanocytic cells appear to be a unique model for the study of tumor progression.
Color quantization and processing by Fibonacci lattices (2001)

Color quantization is sampling of three-dimensional (3-D) color spaces (such as RGB or Lab) which results in a discrete subset of colors known as a color codebook or palette. It is extensively used for display, transfer, and storage of natural images in Internet-based applications, computer graphics, and animation. We propose a sampling scheme which provides a uniform quantization of the Lab space. The idea is based on several results from number theory and phyllotaxy. The sampling algorithm is very much systematic and allows easy design of universal (image-independent) color codebooks for a given set of parameters. The codebook structure allows fast quantization and ordered dither of color images. The display quality of images quantized by the proposed color codebooks is comparable with that of image-dependent quantizers. Most importantly, the quantized images are more amenable to the type of processing used for grayscale ones. Methods for processing grayscale images cannot be simply extended to color images because they rely on the fact that each gray-level is described by a single number and the fact that a relation of full order can be easily established on the set of those numbers. Color spaces (such as RGB or Lab) are, on the other hand, 3-D. The proposed color quantization, i.e., color space sampling and numbering of sampled points, makes methods for processing grayscale images extendible to color images. We illustrate possible processing of color images by first introducing the basic average and difference operations and then implementing edge detection and compression of color quantized images.