gebhart/patrepeval huggingface dataset:
Character-Stroke Detection for Text-Localization and Extraction (2007)

In this paper, we present a new approach for analysis of images for text-localization and extraction. Our approach puts very few constraints on the font, size and color of text and is capable of handling both scene text and artificial text well. In this paper, we exploit two well-known features of text: approximately constant stroke width and local contrast, and develop a fast, simple, and effective algorithm to detect character strokes. We also show how these can be used for accurate extraction and motivate some advantages of using this approach for text localization over other color-space segmentation based approaches. We analyze the performance of our stroke detection algorithm on images collected for the robust-reading competitions at ICDAR 2003.
Increase in Single L-Type Calcium Channels in Hippocampal Neurons During Aging (1996)

Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1 hippocampal neurons during aging. However, the molecular basis for this elevation is not known. The partially dissociated hippocampal ("zipper") slice preparation was used to analyze single Ca2+ channel activity in CA1 neurons of adult and aged rats. Total L-type Ca2+ channel activity in patches was found to increase with aging, primarily because of an increase in the density of functional channels. Learning in aged animals was inversely correlated with channel density. This increase in functional Ca2+ channels with aging could underlie the vulnerability of neurons to age-associated neurodegenerative conditions.
Effect of the Addition of a Cocoa Butter–Like Fat Enzymatically Produced from Olive Pomace Oil on the Oxidative Stability of Cocoa Butter (2009)

A cocoa butter (CB)-like fat was produced in a packed bed enzyme reactor using sn-1,3 specific lipase, and its blends with CB were prepared at different ratios (CB: CB-like fat; 100: 0, 90: 10, 80: 20, 70: 30, 60: 40, 50: 50, 0: 100). The oxidation kinetics of CB: CB-like fat blends was studied by differential scanning calorimeter (DSC). Samples were heated in DSC at different temperatures (130, 140, 150, 160 degrees C) under 100 mL/min oxygen. From DSC exotherms, oxidation induction times (OIT) were determined and used for the assessment of the oxidative stabilities of the blends. Oxidation kinetics parameters (activation energy, E(a); preexponential factor, Z; and oxidation rate constant, k) were calculated. In general, it has been observed that above 110 degrees C increasing the ratio of CB-like fat in the blend increased the k value with increasing temperature. It has been observed that for all blends the increase in k value with temperature was significant (P < 0.05). Increasing CB-like fat ratio in the blend decreased the content of major TAGs (1,3-dipalmitoyl-2-oleoyl-glycerol [POP]; 1[3]-palmitoyl-3[1]stearoyl-2-oleoyl-glycerol [POS]; 1,3-distearoyl-2-oleoyl-glycerol [SOS]), and decreased the oxidative stability of the blends.
How Long to Wait for a Response to Clozapine: A Comparison of Time Course of Response to Clozapine and Conventional Antipsychotic Medication in Refractory Schizophrenia (1999)

This study compared the time course to clinical improvement with clozapine and with conventional antipsychotic medications. A double-blind trial compared clozapine and haloperidol in patients with schizophrenia who were refractory to conventional antipsychotic medication and were hospitalized for 30 to 364 days at 15 Veteran Affairs medical centers during the year before study entry. Patients in the original study were randomly assigned to haloperidol or clozapine and followed for 12 months, at maximum tolerable doses. Patients who completed a full year of treatment with clozapine (n = 122), or with either haloperidol or another conventional antipsychotic medication (n = 123) and who also completed the 9- or 12-month assessment were included. Response to treatment was defined as 20 percent improvement on standard scales of symptoms and quality of life at the latter of the 9- or 12-month interviews. More patients assigned to clozapine achieved 20 percent improvement in symptoms at each followup. Among patients who did not improve at 6 weeks, 3 months, or 6 months, there were no significant differences between clozapine and comparison patients in outcomes at 1 year. Among patients who did improve, maintenance of that improvement also did not differ between the groups at 1 year on symptom measures. Maintenance of improvement in quality of life at 1 year was significantly greater for clozapine patients who had improved at 6 months (p < 0.04). Significant differential symptom response to clozapine occurred exclusively during the first 6 weeks of treatment.
Stomach Cancer (2006)

Abstract This chapter reviews the epidemiology of stomach cancer, focusing on adenocarcinoma of the stomach, including that of the gastric cardia and gastoesophageal junction. Topics covered include classification, preneoplasia, demographic patterns, environmental factors, host factors, and preventive measures.
Model building for dynamic multi-tenant provider environments (2012)

Increasingly, storage vendors are finding it difficult to leverage existing white-box and black-box modeling techniques to build robust system models that can predict system behavior in the emerging dynamic and multi-tenant data centers. White-box models are becoming brittle because the model builders are not able to keep up with the innovations in the storage system stack, and black-box models are becoming brittle because it is increasingly difficult to a priori train the model for the dynamic and multi-tenant data center environment. Thus, there is a need for innovation in system model building area. In this paper we present a machine learning based blackbox modeling algorithm called M-LISP that can predict system behavior in untrained region for these emerging multitenant and dynamic data center environments. We have implemented and analyzed M-LISP in real environments and the initial results look very promising. We also provide a survey of some common machine learning algorithms and how they fare with respect to satisfying the modeling needs of the new data center environments.
Phase I/II Clinical Study of Tosedostat, an Inhibitor of Aminopeptidases, in Patients With Acute Myeloid Leukemia and Myelodysplasia (2010)

This phase I/II study demonstrates that oral once daily dosing with 130 mg tosedostat is well tolerated and has significant antileukemic activity. The favorable risk-benefit profile suggests that further clinical trials are warranted.
Simulating User''s Preferences: Towards Automated Artificial Evolution for Computer Generated Images (1993)

In 1991, Karl Sims presented work on artificial evolution in which he used genetic algorithms to evolve complex structures for use in computer generated images and animations. The evolution of the computer generated images progressed from simple, randomly generated shapes to interesting images which the users interactively created. The evolution advanced under the constant guidance and supervision of the user. This paper describes attempts to automate the process of image evolution through the use of artificial neural networks. The central objective of this study is to learn the user''s preferences, and to apply this knowledge to evolve aesthetically pleasing images which are similar to those evolved through interactive sessions with the user. This paper presents a detailed analysis of both the shortcomings and successes encountered in the use of five artificial neural network architectures. Further possibilities for improving the performance of a fully automated system are also discussed.
Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging (2014)

Yttrium-90 is known to have a low positron emission decay of 32 ppm that may allow for personalized dosimetry of liver cancer therapy with 90Y labeled microspheres. The aim of this work was to image and quantify 90Y so that accurate predictions of the absorbed dose can be made. The measurements were performed within the QUEST study (University of Sydney, and Sirtex Medical, Australia). A NEMA IEC body phantom containing 6 fillable spheres (10–37 mm ∅) was used to measure the 90Y distribution with a Biograph mCT PET/CT (Siemens, Erlangen, Germany) with time-of-flight (TOF) acquisition. A sphere to background ratio of 8∶1, with a total 90Y activity of 3 GBq was used. Measurements were performed for one week (0, 3, 5 and 7 d). he acquisition protocol consisted of 30 min-2 bed positions and 120 min-single bed position. mages were reconstructed with 3D ordered subset expectation maximization (OSEM) and point spread function (PSF) for iteration numbers of 1–12 with 21 (TOF) and 24 (non-TOF) subsets and CT based attenuation and scatter correction. Convergence of algorithms and activity recovery was assessed based on regions-of-interest (ROI) analysis of the background (100 voxels), spheres (4 voxels) and the central low density insert (25 voxels). For the largest sphere, the recovery coefficient (RC) values for the 30 min –2-bed position, 30 min-single bed and 120 min-single bed were 1.12±0.20, 1.14±0.13, 0.97±0.07 respectively. For the smaller diameter spheres, the PSF algorithm with TOF and single bed acquisition provided a comparatively better activity recovery. Quantification of Y-90 using Biograph mCT PET/CT is possible with a reasonable accuracy, the limitations being the size of the lesion and the activity concentration present. At this stage, based on our study, it seems advantageous to use different protocols depending on the size of the lesion.
Modulation of leucocyte adhesion molecules, a T-cell chemotaxin (IL-8) and a regulatory cytokine (TNF-α) in allergic contact dermatitis (rhus dermatitis) (1991)

To understand the molecular events which are important in leucocyte trafficking in cutaneous inflammation, poison ivy/oak extract was applied topically to the skin, and the simultaneous assessment of a variety of clinical and immunopathological parameters performed. The clinical response of subjects was divided into three main groups: I, 2-24h after application, before the onset of erythema; II, 48 h-1 week after application during maximal clinical changes; III, 2-3 weeks after application when the inflammation had subsided. Six different biopsies per subject were evaluated over the study period and the density of dermal cellular infiltrate, and the distribution of intercellular adhesion molecule-1, (ICAM-1), endothelial leucocyte adhesion molecule-1, (ELAM-1), vascular cell adhesion molecule-1, (VCAM-1), interleukin 8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha), determined. Eight hours after exposure, before lymphocytes and monocytes had entered the dermal interstitium or epidermis, the keratinocytes expressed TNF-alpha and ICAM-1, whilst the endothelial cells expressed ELAM-1, VCAM-1 and ICAM-1. Group II biopsies revealed increasing keratinocyte expression of TNF-alpha and ICAM-1 with the appearance of IL-8, which correlated with the onset of epidermal T-cell trafficking. The endothelium was strongly positive for ELAM-1 and VCAM-1, but there was no influx of neutrophils. Group III biopsies showed a decrease in the expression of ICAM-1, VCAM-1 and ELAM-1 by both keratinocytes and endothelium with a reduction in epidermal/dermal inflammation, although the endothelial cell staining of VCAM-1 and ELAM-1 did not completely disappear. These results suggest that on exposure to poison ivy/oak, keratinocytes rapidly produce TNF-alpha which leads to an early autoinduction of ICAM-1, and later IL-8. There is also a paracrinemediated induction and augmentation of underlying endothelial cell ELAM-1, VCAM-1 and ICAM-1.
Electrophile-Functionalized Metallocene Intermediates. Application in the Diastereoselective Synthesis of a Tetramethyldisiloxane-Bridged <i>C</i><sub>2</sub>-Symmetric <i>ansa</i>-Zirconocene Dibromide (1999)

The reactivity of group 4 zirconocene dichlorides incorporating (1-trimethylsilyl)-η5-indenyl (Me3SiInd) and η5-1-(trimethylsilyl)-4,5,6,7-tetrahydroindenyl (Me3SiTHI) ligands toward boron tribromide was investigated. Whereas the reaction of (Me3SiInd)CpZrCl2 (1) with BBr3 in CH2Cl2 immediately cleaved the indenyl ligand from the metal, (Me3SiTHI)CpZrCl2 (3) reacted with BBr3 in CH2Cl2 at 70 °C for 2 days to obtain [1-(BrSiMe2)THI]CpZrBr2 (6) in 49% yield. The reaction of (Me3SiInd)Li (2 equiv) with ZrCl4(THF)2 afforded pure rac-(Me3SiInd)2ZrCl2 (2) in 60% yield. Hydrogenation of (2) (50 bar, PtO2 catalyst) afforded rac-(Me3SiTHI)2ZrCl2 (4) in 81% yield. Single-crystal X-ray diffraction analysis of 4 showed that the Zr atom lies on a crystallographic C2 axis with the C4H8 annelated rings projecting into the ZrCl2 hemisphere of the pseudotetrahedral coordination environment. The reaction of 4 with MeLi in toluene afforded rac-(Me3SiTHI)2ZrMe2 (5) in 62% yield. 1H NMR and 13C NMR analysis confirmed the rac assignment for 5. Treatment of 4 with BBr3 in CH2Cl2 at 70 °C for 2 days afforded rac-[1-(BrMe2Si)THI]2ZrBr2 (7) in 78% yield. The reaction of 7 with moisture in ambient air gave the ansa-metallocene rac-[μ-O−(1-Me2SiTHI)2]ZrBr2 (8) in 97% yield. In solution, 8 showed time-averaged C2 symmetry (1H NMR); however, single-crystal X-ray diffraction analysis showed that 8 adopts an asymmetric conformation in which only one of the C4H8 annelated rings projects into the ZrCl2 coordination hemisphere. Neither 4 nor 8 served as a precatalyst for alumoxane-cocatalyzed, homogeneous propylene polymerization.
Understanding How Commensal Obligate Anaerobic Bacteria Regulate Immune Functions in the Large Intestine (2014)

The human gastrointestinal tract is colonised by trillions of commensal bacteria, most of which are obligate anaerobes residing in the large intestine. Appropriate bacterial colonisation is generally known to be critical for human health. In particular, the development and function of the immune system depends on microbial colonisation, and a regulated cross-talk between commensal bacteria, intestinal epithelial cells and immune cells is required to maintain mucosal immune homeostasis. This homeostasis is disturbed in various inflammatory disorders, such as inflammatory bowel diseases. Several in vitro and in vivo studies indicate a role for Faecalibacterium prausnitzii, Bacteroides thetaiotaomicron, Bacteroides fragilis, Akkermansia muciniphila and segmented filamentous bacteria in maintaining intestinal immune homeostasis. These obligate anaerobes are abundant in the healthy intestine but reduced in several inflammatory diseases, suggesting an association with protective effects on human health. However, knowledge of the mechanisms underlying the effects of obligate anaerobic intestinal bacteria remains limited, in part due to the difficulty of co-culturing obligate anaerobes together with oxygen-requiring human epithelial cells. By using novel dual-environment co-culture models, it will be possible to investigate the effects of the unstudied majority of intestinal microorganisms on the human epithelia. This knowledge will provide opportunities for improving human health and reducing the risk of inflammatory diseases.
A hybrid method for uplink ACK/NACK signaling (2009)

This paper proposes a hybrid method of uplink ACK/NACK signaling combining the advantages of both the non-coherent and the coherent methods. Simulations show that the proposed method improves the SNR performance by about 1 dB at the BER of 10 - 4 when compared with the coherent methods, with little loss in actual multiplexing capacity.
Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone (2004)

The aim of this paper was to investigate whether rotenone, a pesticide causing experimental parkinsonism, causes direct damage to dopaminergic structure when injected intracerebrally and whether this action may be prevented by peripheral administration of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), an endogenous compound with anti-dopaminergic activity. Male Wistar rats were injected unilaterally into the median forebrain bundle with 2 mg rotenone, and received 1MeTIQ, 50 mg/kg i.p. 1 h before and then daily for 21 d. To compare the effect of intracerebral and peripheral treatment, rotenone was also given once or for 7 d in a dose of 10 mg/kg s.c. Dopamine, serotonin and their metabolites were assessed by HPLC in the substantia nigra and striatum. While a single subcutaneous rotenone dose did not produce any change in striatal dopamine metabolism, the multiple treatments resulted in changes suggesting a shift in the metabolism towards oxidative desamination and reduction of O-methylation. In contrast to systemic injections, intracerebral-administered rotenone produced a decrease in dopamine and its metabolites content in the striatum (dopamine decrease by 70 %) and substantia nigra (dopamine decrease by 35 %), without affecting the serotonin system. As those changes were observed 21 d after the injection of rotenone, they suggest a durable neurotoxic effect. The treatment with 1MeTIQ strongly reduced the fall of striatal dopamine concentration. The data suggest that rotenone given peripherally affects metabolic processes in dopaminergic neurons, and this seems to result from its neurotoxic action, which may be observed after an intracerebral injection. 1MeTIQ is able to counteract the damaging action of rotenone and seems to be a potential neuroprotective agent.
Screening of subtype-specific activators and inhibitors for diacylglycerol kinase (2019)

Diacylglycerol kinase (DGK) is a lipid kinase that converts diacylglycerol (DG) into phosphatidic acid (PA). DG and PA function as lipid messengers contributing to various signalling pathways. Thus, DGK plays a pivotal role in the signalling pathways by maintaining DG and PA levels. For example, DGKδ is involved in diabetes and DGKβ is important for higher brain function including memory and emotion. Recently, we also revealed that the activation of DGKα ameliorated diabetic nephropathy (DN) in mice, suggesting that DGK can be therapeutic target. However, there is no commercially available DGK subtype-specific inhibitors or activators. Therefore, in a series of experiment to find DGK subtype-specific inhibitors or activators, we tried to screen novel DGKα activators from 9,600 randomly selected compounds by using high-throughput screening we had recently developed. Finally, we obtained two lead compounds for DGKα activators, KU-8 and KU-10. Focusing KU-8, we assessed the effect of KU-8 on all mammalian DGKs activities. Thus, KU-8 activates not only DGKα but also DGKθ by approximately 20%, and strongly inhibited DGKκ. In conclusion, KU-8 would be a good lead compound for DGKα and DGKθ activators, and useful as a DGKκ inhibitor.
A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution. (1986)

Rat liver cytosol has low hydrolytic activity against [3H]methylcasein at neutrality, but activity increases greatly on addition of various compounds such as poly-L-lysine, N-ethylmaleimide, and sodium dodecyl sulfate, suggesting that it contains latent proteolytic activity. The latent enzyme was found to be stabilized in the presence of 20% glycerol and to be activated by addition of poly-L-lysine. The latent enzyme was purified from a crude extract of rat liver to apparent homogeneity in the presence of 20% glycerol by conventional chromatographic techniques. The purified enzyme showed endoproteolytic activity toward various proteins when it was activated by the compounds listed above. It preferentially degraded N-substituted tripeptide substrates with a basic amino acid at the carboxyl terminus, as well as peptides containing neutral hydrophobic amino acids. It did not require activation for these peptidase activities, in contrast to its activity toward large proteins. Interestingly, a proteinase and a trypsin-like and a chymotrypsin-like peptidase activity could not be separated by customary chromatographic methods but were distinguishable by their sensitivities to various inhibitors, activators, and covalent modifiers, suggesting that the enzyme has three distinct active sites within a single protein. The enzyme seems to be a seryl endopeptidase showing maximal activity at neutral and weakly alkaline pH values. Thus, the enzyme is a unique protease with latent multifunctional catalytic sites. The distribution of the protease in soluble extracts of various rat tissues and cells was examined quantitatively by an enzyme immunoassay. The enzyme level was highest in liver and also in spleen, stomach, lung, small intestine, and kidney, but was low in heart, diaphragm, skeletal muscle, brain, and skin. The concentrations of enzyme in some established cell lines including hepatoma and rat kidney cells were comparable to that in normal liver hepatocytes. The enzyme was found mainly in the cytosol fraction, although a small amount was associated with microsomal membranes, suggesting that it is an extralysosomal protease. Immunohistochemical staining of the liver and skeletal muscles showed that the protease is distributed diffusely in panlobular hepatocytes with slight centrilobar predominance and is present in Kupffer cells, vascular endothelial cells, and bile duct epithelial cells in the liver and also diffusely in the intermyofibrillar spaces and vascular endothelial cells in skeletal muscle. The quantitative data obtained in the present study indicate the presence of the protease in the cytosol fraction of all rat tissues.(ABSTRACT TRUNCATED AT 400 WORDS)
Signal Processing with Nonlinear Integrated Optics (1979)

We present here the integrated optics analog to the well-known surface acoustic wave convolver. Picosecond signal processing capabilities are achieved by the non-degenerate four wave mixing in a Ti in-diffused LiNbO3 waveguide. This second order interaction between two oppositely propagating guided modes was observed to generate a radiation field at the sum frequency into a direction normal to the waveguide surface during the pulse overlap. The potential applications of this phenomenon to processing functions such as convolution, time inversion etc., to precision timing and picosecond metrology, and to ultra-fast transient digitizers are discussed.
Disease‐specific patterns of locus coeruleus cell loss (1992)

Computer visualization techniques were used to map and to quantitatively reconstruct the entire locus coeruleus, including the nucleus subcoeruleus, to compare the topographic patterns of cell loss in postmortem brains from patients with Parkinson's disease, Alzheimer's disease, and Down syndrome. There was comparable cell loss in all three diseases (approximately 60%) compared with aged normal subjects, and there was a significant loss of nucleus subcoeruleus cells specifically in patients with Parkinson's disease (63%). There was a significant positive correlation between the magnitude of locus coeruleus cell loss and the duration of Alzheimer's disease, but no such correlation was found for Parkinson's disease. In patients with Parkinson's disease, there was comparable cell loss throughout the rostral-caudal extent of the nucleus; however, in patients with Alzheimer's disease and Down syndrome, the greatest cell loss always occurred within the rostral portion of the nucleus, with a relative sparing of caudal cells. These data are consistent with the hypothesis that cell loss in Parkinson's disease is the result of a pathological process that attacks the catecholaminergic cells of the locus coeruleus and the subcoeruleus in general; in Alzheimer's disease and Down syndrome, however, the pathological process only affects the rostral, cortical-projecting locus coeruleus cells and spares the caudal, noncortical-projecting cells.