gebhart/patrepeval huggingface dataset:
Vaccination with Plasmid DNA Encoding Mycobacterial Antigen 85A Stimulates a CD4<sup>+</sup>and CD8<sup>+</sup>T-Cell Epitopic Repertoire Broader than That Stimulated by<i>Mycobacterium tuberculosis</i>H37Rv Infection (1998)

Vaccination of mice with plasmid DNA carrying the gene for the major secreted mycobacterial antigen 85A (Ag85A) from Mycobacterium tuberculosis is a powerful technique for generating robust specific Thl helper T-cell responses, CD8+-mediated cytotoxicity, and protection against M. tuberculosis challenge (K. Huygen et al., Nat. Med. 2:893-898, 1996). We have now analyzed in more detail the antigen-specific immune CD4+- and CD8+-T-cell responses induced in BALB/c mice vaccinated with Ag85A DNA and have compared these responses to those generated by intravenous infection with M. tuberculosis. T-cell-epitope mapping, as measured by interleukin-2 and gamma interferon secretion from splenic T cells restimulated in vitro with synthetic 20-mer peptides spanning the complete mature sequence of Ag85A, demonstrated that DNA vaccination stimulated a stronger and broader T-cell response than did M. tuberculosis infection. Moreover, elevated cytotoxic T lymphocyte (CTL) activity against Ag85A-transfected and peptide-pulsed P815 target cells could be generated exclusively by vaccination with plasmid DNA, not following M. tuberculosis infection. By using DNA vaccination, three Ag85A CTL epitopes with predicted major histocompatibility complex class I binding motifs were defined. One of them was previously reported as a dominant, promiscuously recognized T-cell epitope in healthy humans with primary infections. These data strengthen the potential of DNA vaccination with respect to inducing antituberculous immunity in humans.
Method and apparatus for measuring dynamic response characteristics of shock accelerometer (1991)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Akira Umeda, Kazunaga Ueda; Method and apparatus for measuring dynamic response characteristics of shock accelerometer. J. Acoust. Soc. Am. 1 December 1991; 90 (6): 3387. https://doi.org/10.1121/1.401378 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Chromosome 18 markers: Linked or not linked to bipolar affective disorders in the Old Order Amish? A reply to Gershon et al. (1996)

We appreciate the careful review of our paper by examining linkage of bipolar affective disorder (BAD) to markers on chromosome 18. These authors have raised several issues concerning our article and specifically challenge our conclusion concerning the presence or absence of a major susceptibility locus for BAD on chromosome 18 in the Old Order Amish sample. 9 refs.
All Digital Spread Spectrum Clock Generator for (2007)

An effective solution to control electromagnetic inter- ference in computing appliances such as DVD players or home the- ater systems is to apply modulation on the system clock. The pres- ence of modulation on the clock reduces the radiated power per unit bandwidth. We present the implementation of a spread spec- trum clock generator (SSCG) using strictly digital components. A digital delay line (DDLi) controlled by a small digital circuit is used to increase or decrease the delay on a clock and hence create a mod- ulated output. The DDLi total electrical length is no longer than one period of the 27-MHz reference clock as the digital circuit can adjust to the limited length of the line. The circuit can produce up or down spread by modulating the frequency of the reference with a triangular waveform. The measured peak power reduction is greater than 13 dB for a deviation of about 3% and a frequency modulation of 100 kHz. A real-time digital calibration circuit en- ables a process and temperature independent operation. The cir- cuit occupies 0.06 mm in a 0.15- m CMOS process and consumes 7.1 mW.
<title>Coating tolerant thermography for the detection of cracks in structures</title> (1997)

A new variation of forced-diffusion thermography, coating tolerant forced diffusion thermography, is described. This new thermal method is specifically designed to inspect large steel bridge structures. To increase effectiveness in the field coating tolerant thermography separates the effects of structural defects from variations in emissivity. The technique is a derivative of forced diffusion thermography which uses patterned radiation to force heat flow in-plane to specifically target cracks. This paper presents the fundamentals of coating tolerant forced diffusion thermography including the mathematical bases for the separation of thermal gradients and emissivity gradients. Also, presented are case studies including the inspection of a bridge girder samples at FHWA Turner Fairbanks Lab.
Large aperture deformable mirror with a transferred single-crystal silicon membrane actuated using large-stroke PZT Unimorph Actuators (2005)

We have demonstrated a large aperture (50 mm x 50 mm) continuous membrane deformable mirror (DM) with a large-stroke piezoelectric unimorph actuator array. The DM consists of a continuous, large aperture, silicon membrane 'transferred' in its entirety onto a 20 x 20 piezoelectric unimorph actuator array. A PZT unimorph actuator, 2.5 mm in diameter with optimized PZT/Si thickness and design showed a deflection of 5.7 [m at 20V. An assembled DM showed an operating frequency bandwidth of 30 kHz and influence function of approximately 30%.
The Mysteries of Proanthocyanidin Transport and Polymerization (2010)

Article on the mysteries of proanthocyanidin transport and polymerization.
Abstract 1819: A MUC1-C oncoprotein soluble decoy receptor effectively suppresses the growth of human breast cancer cells (2012)

Abstract The Mucin 1 (MUC1) transmembrane glycoprotein is aberrantly overexpressed by most human breast carcinomas and contributes to the malignant phenotype. MUC1 is expressed as two subunits (MUC1-N and MUC1-C) that form a stable heterodimer at the cell surface. MUC1-N is shed to contribute to a protective physical barrier, leaving the oncogenic MUC1-C subunit at the cell surface as a putative receptor for signaling the presence of stress to the interior of the cell. As shown for the VEGF receptor TRAP, aflibercept, a potential approach for blocking MUC1-C function is to generate a soluble decoy receptor by fusing the MUC1-C extracellular domain to an Ig constant (Fc) region. The present studies demonstrate that in vitro treatment of human ZR-75-1 breast carcinoma cells with the MUC1-C soluble decoy receptor is associated with a dose-dependent induction of cell death. Similar findings were obtained with human MCF-7 breast cancer cells. To explore the potential of the MUC1-C soluble decoy receptor as an anti-cancer agent, we evaluated its ability to block the growth of breast cancer cells in subcutaneous tumor xenograft models growing in nude mice. Administration of the MUC1-C soluble decoy receptor to nude mice bearing established ZR-75-1 breast tumor xenografts was associated with a dose-dependent loss of tumorigenicity and prolonged tumor regressions after completing therapy. Taken together, these findings demonstrate that targeting the MUC1-C oncoprotein with a soluble decoy receptor is effective in inducing death of human breast cancer cells in vitro and in tumor models. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1819. doi:1538-7445.AM2012-1819
Solution Structure of a Prion Protein: Implications for Infectivity (1998)

Prions cause neurodegenerative diseases in animals and humans. The scrapie prion protein (PrPSc) is the major-possibly only-component of the infectious prion and is generated from the cellular isoform (PrPC) by a conformational change. Limited proteolysis of PrPSc produces an polypeptide comprised primarily of residues 90 to 231, which retains infectivity. The three-dimensional structure of rPrP(90-231), a recombinant protein resembling PrPC with the Syrian hamster (SHa) sequence, was solved using multidimensional NMR. Low-resolution structures of rPrP(90-231), synthetic peptides up to 56 residues, a longer (29-231, full-length) protein with SHa sequence, and a short here further structure refinement of rPrP(90-231) and dynamic features of the protein. Consideration of these features in the context of published data suggests regions of conformational heterogeneity, structural elements involved in the PrPC\longrightarrowPrPSc transformation, and possible structural features related to a species barrier to transmission of prion diseases.
Possible Effect of Binaural Beat Combined With Autonomous Sensory Meridian Response for Inducing Sleep (2019)

Sleep is important to maintain physical and cognitive functions in everyday life. However, the prevalence of sleep disorders is on the rise. One existing solution to this problem is to induce sleep using an auditory stimulus. When we listen to acoustic beats of two tones in each ear simultaneously, a binaural beat is generated which induces brain signals at a specific desired frequency. However, this auditory stimulus is uncomfortable for users to listen to induce sleep. To overcome this difficulty, we can exploit the feelings of calmness and relaxation that are induced by the perceptual phenomenon of autonomous sensory meridian response (ASMR). In this study, we proposed a novel auditory stimulus for inducing sleep. Specifically, we used a 6 Hz binaural beat corresponding to the center of the theta band (4-8 Hz), which is the frequency at which brain activity is entrained during non-rapid eye movement (NREM) in sleep stage 1. In addition, the "ASMR triggers" that cause ASMR were presented from natural sound as the sensory stimuli. In session 1, we combined two auditory stimuli (the 6 Hz binaural beat and ASMR triggers) at three-decibel ratios to find the optimal combination ratio. As a result, we determined that the combination of a 30:60 dB ratio of binaural beat to ASMR trigger is most effective for inducing theta power and psychological stability. In session 2, the effects of these combined stimuli (CS) were compared with an only binaural beat, only the ASMR trigger, or a sham condition. The combination stimulus retained the advantages of the binaural beat and resolved its shortcomings with the ASMR triggers, including psychological self-reports. Our findings indicate that the proposed auditory stimulus could induce the brain signals required for sleep, while simultaneously keeping the user in a psychologically comfortable state. This technology provides an important opportunity to develop a novel method for increasing the quality of sleep.
WO<sub>3</sub> as a nucleating agent for BaO/SrO/ZnO/SiO<sub>2</sub> glasses – experiments and simulations (2018)

In glasses from the BaO–SrO–ZnO–SiO<sub>2</sub> system, the addition of up to 4 mol% WO<sub>3</sub> leads to volume crystallization.
Where is the far-point in aberrated eyes? (2002)

Purpose: We sought a method for deducing the far-point of an aberrated eye from an aberration map. Such a method is necessary for successful implementation of wavefront-guided treatments. Method. Accommodation was paralyzed and pupils dilated in both e yes of 100 subjects. Subjective refractions determined the spectacle correction needed to maximize visual acuity for high-contrast letters. Sphero-cylindrical refractive errors were corrected with trial lenses when measuring monochromatic abe r rations (633nm) with a Shack-Hartmann aberrometer. Resulting aberration maps were fit with spherical wavefronts four ways to yield four different estimates of the far point for each eye. Method 1 minimized the RMS error b etween the given wavefro nt and the s pherical wave over the full pupil. Method 2 determined the spherical wavefront which had the same paraxial curvature as the meridionally-averaged curvature of the given aberration map. Method 3 maximized the pupil area over which RMS wavefron t error was less than a criterion level of 1/4 wavelength. Method 4 maximized the pupil area over which the absolute wavefront error was less than 1/4 wavelength. Results: A successful method will yield a far point at infinity sinc e all eyes were emmetro pic when t ested. Method 1 was a clear failure, predicting a mean far point vergence of −0.26D for the study population. The other three methods all yielded far points which, on average, had vergence close to 0D (Method 2: mean=0.0 23 , std=0.296. Metho d 3: mean =0.05 , std=0.33. Method 4: mean=0.004 , std=0.55). Methods 2 and 3 yield standard deviations close to the expected minimum (0.25D) set by the variability of subjective refraction. Conclusion: Three successful methods for u sing an aberration map to locate the far point of the eye have been found. One unsuccessful method is equivalent to the Zernike coefficient for defocus.
Preparation of Amorphous Boron Nitride from the Reaction of Haloborazines with Alkali Metals and Formation of a Novel Tubular Morphology by Thermal Annealing (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Amorphous Boron Nitride from the Reaction of Haloborazines with Alkali Metals and Formation of a Novel Tubular Morphology by Thermal AnnealingEwan J. M. Hamilton, Shawn E. Dolan, Charles M. Mann, Hendrik O. Colijn, and Sheldon G. ShoreCite this: Chem. Mater. 1995, 7, 1, 111–117Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/cm00049a017https://doi.org/10.1021/cm00049a017research-articleACS PublicationsRequest reuse permissionsArticle Views378Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phosphorus Dendrimer Derived Solid Sorbents for CO<sub>2</sub> Capture from Post-Combustion Gas Streams (2018)

Solid amine sorbents were prepared via cross-linking of polyamine compounds and polyaldehyde phosphorus dendrimers through a reductive amination approach. The CO2 adsorption capacities from inert gas streams and simulated flue gas were determined using a thermogravimetric analyzer (TGA) and a packed-bed reactor, (PBR) respectively. The sorbents adsorbed CO2 from inert CO2 gas streams up to 7.3 wt % at 65 °C and 10.7 wt % at 25 °C, while adsorbing CO2 from simulated flue gas up to 7.4 wt % at 65 °C. The amines are covalently bound in the sorbent, providing a robust material that is stable at elevated temperatures and does not leach upon exposure to moisture. The sorbents underwent extensive cycle testing, with no degradation observed up to 45 cycles on the TGA and up to 25 cycles on the PBR, while displaying rapid kinetics for both adsorption and desorption of CO2.
Optimized process gases for mechanized welding applications (2005)

In welding of metallic materials technologically and economically best results can only be obtained, when all the parameters relevant for the welding process are properly set up for the welding task. Besides the welding machine and the filler material this also applies to the choice of the process gas. The use of special gas mixtures can enable a great improvement of the welding process, the shielding gas changes turns from a commodity to an optimising tool. Shielding gases, when optimised with respect to the welding application, can enable higher productivity and provide better quality of the weld. To achieve this, the gas components with their specific properties must be carefully combined. In GMA welding of structural steels for example an addition of helium to the gas can lead to higher travel speeds without impairing penetration profile or producing undercuts. Gas-shielded arc welding of aluminium or nickel alloys is more and more carried out using a process gas containing very small amounts of oxygen or carbon dioxide, which provides excellent arc stability and weld appearance. In mechanised welding applications having a good arc stability is particularly important, since the machine can, unlike a manual welder, hardly react to glitches in the arc.
Translation Regulation by Eukaryotic Initiation Factor-2 Kinases in the Development of Latent Cysts in Toxoplasma gondii (2008)

A key problem in the treatment of numerous pathogenic eukaryotes centers on their development into latent forms during stress. For example, the opportunistic protist Toxoplasma gondii converts to latent cysts (bradyzoites) responsible for recrudescence of disease. We report that Toxoplasma eukaryotic initiation factor-2alpha (TgIF2alpha) is phosphorylated during stress and establish that protozoan parasites utilize translation control to modulate gene expression during development. Importantly, TgIF2alpha remains phosphorylated in bradyzoites, explaining how these cells maintain their quiescent state. Furthermore, we have characterized novel eIF2 kinases; one in the endoplasmic reticulum and a likely regulator of the unfolded protein response (TgIF2K-A) and another that is a probable responder to cytoplasmic stresses (TgIF2K-B). Significantly, our data suggest that 1) the regulation of protein translation through eIF2 kinases is associated with development, 2) eIF2alpha phosphorylation is employed by cells to maintain a latent state, and 3) endoplasmic reticulum and cytoplasmic stress responses evolved in eukaryotic cells before the early diverging Apicomplexa. Given its importance to pathogenesis, eIF2 kinase-mediated stress responses may provide opportunities for novel therapeutics.
Prediction of Neoadjuvant Chemoradiotherapy Response in Rectal Cancer with Metric Learning Using Pretreatment 18F-Fluorodeoxyglucose Positron Emission Tomography (2021)

The new ML model presented herein was used to determined that baseline 18F[FDG]-PET/CT images could predict a favorable response to NCRT in patients with rectal cancer. External validation is required to verify the model's predictive value.
Practical Scheme for Arterial Travel Time Estimation Based on Vehicle Reidentification Using Wireless Sensors (2009)

A scheme is described for the real-time estimation of travel time across an arterial segment with multiple intersections. The scheme relies on re-identification of vehicle signatures from wireless sensors. The sensors provide a noisy magnetic signature of a vehicle and the precise time when it crosses the sensors. A match (re-identification) of signatures at two locations gives the corresponding vehicle travel time. The matching results also give the delay distribution, signal phase and discharge rate, queue length, and number of vehicles in the link. The matching algorithm is based on a statistical model of the signatures. The model itself is estimated from the data, and does not require measurement of ‘ground truth’. The scheme does not require measurements of signal settings; in fact, signal settings can be inferred from results of the matching algorithm. The scheme is tested on a 0.9 mile-long segment of San Pablo Avenue in Albany, CA, under different traffic conditions. The segment is divided into three links: one link spans four intersections, and two links span a single intersection each.
The dual nature of HDL: Anti‐Inflammatory and pro‐Inflammatory (2015)

High density lipoprotein (HDL) has long been considered a protective factor against the development of coronary heart disease. Two important roles of HDL include reverse cholesterol transport (RCT) and the modulation of inflammation. The main protein component of HDL; apolipoprotein A-I (apo A-I) is primarily responsible for RCT. Apo A-I can be damaged by oxidative mechanisms, which reduce the protein's ability to promote RCT. In disease states such as diabetes, associated with a chronic acute-phase response, HDL has been found to be dysfunctional and pro-inflammatory. HDL cholesterol levels do not predict composition and/or function and therefore it is important to evaluate the quality and not just the quantity of HDL cholesterol when considering the risk of cardiovascular events. In clinical practice, there are currently no widely available tests for measuring the composition, functionality, and inflammatory properties of HDL. Small peptides that mimic some of the properties of apo A-I have been shown in pre-clinical models to improve HDL function and reduce atherosclerosis without altering HDL cholesterol levels. Clinical trials using HDL and HDL mimetics as therapeutic agents are currently underway. Results in animal studies and early clinical trials will be reviewed.
Annealing temperature effects on the structure of ferromagnetic Mn-implanted Si (2006)

The dependence of the magnetization of Mn-implanted Si on the postimplant annealing temperature is studied. p-type Si wafers were implanted with 300keV Mn+ ions at 350°C to a fluence of 1×1016cm−2 and then annealed at 500–900°C for 5min. Ferromagnetic hysteresis loops were obtained at 10K using a superconducting quantum interference device magnetometer. The saturation magnetization increases with the postimplant annealing temperature, reaching an optimum field strength of 0.2emu∕g at 800°C. An out diffusion of Mn is observed at higher temperatures that coincides with a decrease in the saturation magnetization. The calculated point-defect profile that was generated by the implantation process peaks around the Mn-depleted region, suggesting that the residual implant damage may play a role in the ferromagnetic behavior of Mn-implanted Si.
Supporting Information to: Message Passing Algorithms for Compressed Sensing (2009)

This document presents details concerning analytical derivations and numerical experiments that support the claims made in the main text ‘Message Passing Algorithms for Compressed Sensing’, submitted for publication in the Proceedings of the National Academy of Sciences, USA. Hereafter ’main text’. One can find here: • Derivations of explicit Formulas for the MSE Map, and the optimal thresholds; see Section 3 below. • Proof of Theorem 1; see Section 3 below. • Proof of concavity of the MSE Map, see again Section 3 below. • Explanation of the connection between Minimax Thresholding, Minimax Risk, and rigorous proof of formula [19] in the main text; see Section 4 below, Theorem 4.2. • Formulas for the rate exponent b of Theorem 2 in the main text, expressed in terms of the minimax threshold risk; see Section 5 below.