gebhart/patrepeval huggingface dataset:
Per-Relay Power Minimization for Multi-user Multi-channel Cooperative Relay Beamforming (2016)

We investigate the optimal relay beamforming problem for multi-user peer-to-peer communication with amplify-and-forward relaying in a multi-channel system. Assuming each source-destination (S-D) pair is assigned an orthogonal channel, we formulate the problem as a min-max per-relay power minimization problem with minimum signal-to-noise (SNR) guarantees. After showing that strong Lagrange duality holds for this nonconvex problem, we transform its Lagrange dual problem to a semi-definite programming problem and obtain the optimal relay beamforming vectors. We identify that the optimal solution can be obtained in three cases, depending on the values of the optimal dual variables. These cases correspond to whether the minimum SNR requirement at each S-D pair is met with equality, and whether the power consumption at a relay is the maximum among relays at optimality. We obtain a semi-closed form solution structure of relay beam vectors, and propose an iterative approach to determine relay beam vector for each S-D pair. We further show that the reverse problem of maximizing the minimum SNR with per-relay power budgets can be solved using our proposed algorithm with an iterative bisection search. Through simulation, we analyze the effect of various system parameters on the performance of the optimal solution. Furthermore, we investigated the effect of imperfect channel side information of the second hop on the performance and quantify the performance loss due to either channel estimation error or limited feedback.
3‐O‐Glutaryl‐dihydrobetulin and Related Monoacyl Derivatives as Potent anti‐HIV Agents. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Electro-Optical Characterization of Amorphous Germanium-Tin (Ge1-XSnx) Microbolometer (2022)

Abstract The utilization of amorphous germanium-tin (Ge 1 − x Sn x ) semiconducting thin films as temperature sensing layers in microbolometers was recently presented and patented. The work in this paper started by extending the latest study to acquire better characteristics of the Sn concentrations % for microbolometer applications. In this work, Ge1-xSnx thin films with various Sn concentrations %, x , where 0.31 ≤ x ≤ 0.48 we sputter deposited. Elemental composition was evaluated using Energy Dispersive X-ray (EDX) spectroscopy. Surface morphology was evaluated using Atomic Force Microscopy (AFM) revealing average roughness values between ~ 0.2–0.8 nm. Sheet resistance versus temperature measurements was performed and analyzed revealing temperature coefficients of resistances, TCRs, ranging from − 3.11%/K to -2.52%/K for x ranging from 0.31 to 0.40. The Ge1-xSnx thin film was found to depart the semiconducting behavior at 0.40 < x ≤ 0.48. Empirical relationships are derived relating resistivity, TCR, and Sn concentration % for amorphous Ge1-xSnx thin films. One of the films with 31% Sn concentration (Ge 0.69 Sn 0.31 ) was used to fabricate 10×10 µm2 microbolometer prototypes using electron-beam lithography and liftoff techniques and the microbolometer is fabricated on top of oxidized silicon substrates with no air gap between them. The noise behavior and the maximum detected signal of the fabricated microbolometer were measured. The signal-to-noise ratio, voltage responsivity, and noise equivalent power values of the prototypes were calculated. Finally, the expected performance of the microbolometer when fabricated in an air bridge is calculated.
TNF blockade in rheumatoid arthritis: Implications for therapy and pathogenesis (1997)

The role of the immune response in rheumatoid arthritis (RA) is a subject of debate, although it is widely believed to be a T-cell-driven disease. Progress is being hindered by lack of convincing evidence of a defined specific antigen initiating or perpetuating the response. Clinical trials using monoclonal antibodies directed against T-cell surface molecules such as CD4. CD5, and CD7 have thus far not provided evidence of efficacy. The negative data may reflect inadequate dosing or could suggest that indiscriminate depletion of T cells is insufficient by itself as a therapeutic strategy. Blocking proinflammatory cytokines (e.g. TNF alpha, IL-1) or augmenting anti-inflammatory cytokines (e.g. IL-10) offers an alternative approach to therapy. Clinical trials using monoclonal anti-TNF alpha have been particularly successful in controlling inflammation and markedly reducing acute phase proteins and cellular ingress. However, because disease invariably relapses, repeated therapy is necessary. Preliminary experience suggests that this is possible. Anti-TNF therapy for RA has defined a molecular target and new approach for treating immuno-inflammatory disorders.
Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP). (2009)

We discuss a peptide that targets cells in the acidic tissues that result from a range of pathological states, including tumours, and that can also translocate cell-impermeable cargo molecules across cell membranes in a pH-dependent manner. The technology is based on the interactions of a water-soluble membrane peptide, which we call pHLIP (pH (Low) Insertion Peptide), with the lipid bilayers of cell membranes. at the normal pH of healthy tissue it binds to cell surfaces, but at low pH pHLIP inserts as a monomer across the cell membrane to form a stable transmembrane helix. pHLIP holds promise for imaging and drug delivery applications.
Association Analysis Using Refined Microsatellite Markers Localizes a Susceptibility Locus for Psoriasis Vulgaris Within a 111 kb Segment Telomeric to the HLA-C Gene (1999)

The HLA-Cw6 antigen has been associated with psoriasis vulgaris despite racial and ethnic differences. However, it remains unclear whether it is the HLA-Cw6 antigen itself or a closely linked, hitherto unidentified, locus that predisposes to the disease. Here, in order to map the susceptibility locus for psoriasis vulgaris precisely within the HLA class I region, 11 polymorphic microsatellite markers distributed throughout a 1060 kb segment surrounding the HLA-C locus were subjected to association analysis in Japanese psoriasis vulgaris patients. Statistical analyses of the distribution and deviation from Hardy-Weinberg equilibrium of the allelic frequency at each micro-satellite locus revealed that the pathogenic gene for psoriasis vulgaris is located within a reduced interval of 111 kb spanning 89-200 kb telomeric of the HLA-C gene. In addition to three known genes, POU5F1, TCF19 and S, this 111 kb fragment contains four new, expressed genes identified in the course of our genomic sequencing of the entire HLA class I region. Therefore, these seven genes are the potential candidates for susceptibility to psoriasis vulgaris.
Optically-driven sample rotation for digital holographic microtomography (2017)

We present a novel optically-driven rotation scheme with digital holographic microscopy to compensate an apple core missed data based on full-angel rotation. This technique is successfully implemented to generate a tomographic image of living yeast.
Iterative abstraction using SAT-based BMC with proof analysis (2004)

Resolution-based proof analysis techniques have been proposed recently to identify a sufficient set of reasons for unsatisfiability derived by a CNF-based SAT solver. We have adapted these techniques to work with a hybrid SAT solver. We use the proof analysis technique with SAT-based BMC, in order to, generate useful abstract models. Our abstraction procedure is used iteratively in a top-down framework, starting from the concrete design, where we apply BMC on increasingly more abstract models. We apply various SAT-based and BDD-based verification methods on these abstract models, in order to obtain proofs of correctness, or to perform deeper searches for counterexamples. We demonstrate the effectiveness of our prototype implementation on several large industry designs.
Surface acoustic wave properties of (Pb,Ln)(Ti, Mn, In)O3 ceramics (Ln = La and Nd) (1981)

The surface acoustic wave properties of PbTiO3 ceramics are improved. The ceramic systems investigated are (Pb,Ln)(Ti,Mn,In)O3(Ln = La,Nd). The temperature coefficients of delay time are lowered to 46×10−6/ °C, when Ln is La. A zero temperature coefficient of delay can be achieved when Ln is Nd. The Nd and In substitution also cause the electromechanical coupling factor to increase and the dielectric constant to decrease.
Driver waveform computation for timing analysis with multiple voltage threshold driver models (2008)

This paper introduces an accurate and efficient electrical analysis of logic gates modeled as Multiple Voltage Threshold Models (MVTM) loaded by the associated interconnect. MVTMs formalize a class of gate models which include the existing industry standards, such as CCS and ECSM driver models as special cases. The analysis technique relies on primary MVTM characterization data and does not require explicit instantiation of controlled current source models. Therefore, the method is more accurate, efficient, and general than traditional transient analysis. The theoretical results are validated by detailed simulations and use within full chip timing analysis.
Investigations on Photoresist-Based Artificial Dielectrics With Tall-Embedded Metal Grids and Their Resonator Antenna Application (2015)

Novel photoresist-based artificial bulk dielectrics with tall-embedded metal grids are investigated and their radiation characteristics are studied in detail. The embedded metal grid substantially increases (around six times) the effective permittivity of the low permittivity base photoresist material, and enables excitation with a simple direct microstrip feed to radiate effectively at frequencies similar to a high-permittivity dielectric resonator antenna (DRA). Moreover, the grid changes the near fields inside the resonator and introduces novel modes that are completely different than those of usual DRAs. A set of artificial resonator antennas is designed, lithographically fabricated, and measured to demonstrate the new modes resonating at 17 and 19 GHz with 2% and 6% bandwidth and 7.6 and 6.6 dB broadside gain, respectively, with suitable cross-polarization levels of better than -20 dB. These new modes do not appear simultaneously, and can be excited separately by varying the length of the microstrip feed.
Feasibility demonstration of low pump power operation for 1.48 μm diode-pumped erbium-doped fibre amplifier module (1990)

An optimisation of the erbium-doped fibre greatly improves the 1.48 μm pumping efficiency. The amplifier exhibits 26.2 dB fibre gain for 8 mW launched pump power and 20.2 dB gain for only 5.2 mW pump power, giving an outstanding 3.9 dB/mW gain coefficient.
Long-Term-Stable Near-Infrared Polymer Dots with Ultrasmall Size and Narrow-Band Emission for Imaging Tumor Vasculature <i>in Vivo</i> (2015)

Fluorescent nanoprobes have become one of the most promising classes of materials for cancer imaging. However, there remain many unresolved issues with respect to the understanding of their long-term colloidal stability and photostability in both biological systems and the environment. In this study, we report long-term-stable near-infrared (NIR) polymer dots for in vivo tumor vasculature imaging. NIR-emitting polymer dots were prepared by encapsulating an NIR dye, silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (NIR775), into a matrix of polymer dots, poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV), using a nanoscale precipitation method. The prepared NIR polymer dots were sub-5 nm in diameter, exhibited narrow-band NIR emission at 778 nm with a full width at half-maximum of 20 nm, and displayed a large Stokes shift (>300 nm) between the excitation and emission maxima. In addition, no significant uptake of the prepared NIR polymer dots by either human glioblastoma U87MG cells or human non-small cell lung carcinoma H1299 cells was detected. Moreover, these NIR polymer dots showed long-term colloidal stability and photostability in water at 4 °C for at least 9 months, and were able to image vasculature of xenografted U87MG tumors in living mice after intravenous injection. These results thus open new opportunities for the development of whole-body imaging of mice based on NIR polymer dots as fluorescent nanoprobes.
A Novel Ion Chromatographic Method Using Zwitterionic Surfactants as the Stationary Phase and Water as the Mobile Phase (1997)

Abstract Zwitterionic surfactants immobilized on the surfaces of octadecylsilica (ODS) are used for the stationary phase and water as the mobile phase for the ion chromatography (IC) of target analytes. The creation of an electrical double layer (EDL), when a zwitterionic stationary phase is in contact with the analyte ions, is proposed to explain the separation mechanism. When an EDL is created using a zwitterionic stationary phase (ZWEDL), its properties differ considerably to those of a single charge-fixed stationary phase created EDL. For a ZWEDL, (i) the electrostatic field is increased, resulting in the simultaneous retention and separation of both cations and anions; (ii) the electrostatic affinity between the analytes in the ZWEDL and the stationary phase is extremely weak. This results in the “effective” distribution of the analytes between the stationary phase and the mobile phase without the need for ion-exchange. Since only water is used for the mobile phase, the sensitivity of detection by conductivity is vastly improved and the direct determination (without pre-concentration) of inorganic ions at ultra low levels is possible. Furthermore, since both positive and negative electrostatic fields are produced simultaneously, both analyte cations and anions are retained and separated in a single stage of the stationary phase. This provides the basis for a simple and rapid chromatographic method for the simultaneous analysis of cations and anions.
Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors (2017)

The opioid antagonist naltrexone hydrochloride has been suggested to be a potential therapy at low dosage for multiple inflammatory conditions and cancers. Little is known about the immune-modulating effects of naltrexone, but an effect on the activity of toll-like receptor 4 (TLR4) has been reported. We analyzed the effects of naltrexone hydrochloride on IL-6 secretion by peripheral blood mononuclear cells (PBMC) <i>in vitro</i> following stimulation with ligands for TLR4 and for the intracellular receptors TLR7, TLR8, and TLR9. Naltrexone did not affect cell viability or induce apoptosis of PBMC. Intracellular staining demonstrated that naltrexone inhibited production of IL-6 and TNFα by monocyte and plasmacytoid dendritic cell subsets within the PBMC population following treatment with ligands for TLR7/8 and TLR9, respectively. No effect of cytokine production by PBMC following stimulation of TLR4 was observed. Additionally, naltrexone inhibited IL-6 production in isolated monocytes and B cells after TLR7/8 and TLR9 stimulation, respectively, but no effect on IL-6 production in isolated monocytes after TLR4 stimulation was observed. These findings indicate that naltrexone has the potential to modulate the secretion of inflammatory cytokines in response to intracellular TLR activity, supporting the hypothesis that it may have potential for use as an immunomodulator.
Abstract 2168: Testing the electrical properties of different cell lines using 3DEP reader and compare to TTFields response (2019)

Abstract Background: Tumor Treating Fields (TTFields) are an approved anti-neoplastic treatment modality delivered via application of low intensity, intermediate frequency, alternating electric fields. The electrical properties of cells (such as permittivity and conductivity) determine the optimal frequency of TTFields that incurs the highest reduction in cell counts. Currently, there are no predictive markers for determining TTFields response or the optimal frequency to be applied for individual patient. The goal of this study is to determine the correlation between electrical properties of cells and TTFields’s optimal frequency and sensitivity. The 3DEP reader (LabTech) determines the electrical properties of cells, including permittivity and conductivity, by using Dielectrophoresis (DEP) force. DEP is a physical effect that generates a force on polarizable particles experiencing a non-homogeneous electric field and can therefore be used as a technique to analyse the way cells move within electric fields at different frequencies. Methods: The baseline electrical properties (permittivity and conductivity) of 17 cell lines from different tumor types were determined using the 3DEP reader (LabTech). The curves were analyzed using 2-way ANOVA. The optimal TTFields frequency for each cell line was determined by testing the cytotoxic effect of TTFields at various frequencies using the inovitro system. The electrical properties of cells were compared with the optimal TTFields frequency and sensitivity of each cell line. Results: The results demonstrate significant differences (p&lt;0.001) between the lower frequency range of the 3DEP curves that corresponds to membrane capacitance of cells with TTFields optimal frequency of 150kHz (9 cell lines) and cells with TTFields optimal frequency of 200kHz (8 cell lines). Membrane capacitance was also a good predictor for TTFields sensitivity based on the differences in the curves in the low frequency range. Conclusions: The results presented in this study demonstrate that cell membrane capacitance correlates with TTFields optimal frequency and sensitivity. Based on the above, there is a strong rational to further explore the potential of measuring the electrical properties of cells as a predictive marker to help determine which patient will respond better to TTFields and the optimal TTFields frequency to be applied for each patient. Citation Format: Moshe Giladi, Einav Zeevi, Karnit Gotlib, Cornelia Wenger, Ariel Naveh, Zeev Bomzon, Eilon D. Kirson, Uri Weinberg, Adrian Kinzel, Yoram Palti. Testing the electrical properties of different cell lines using 3DEP reader and compare to TTFields response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2168.
Biologically Inspired Smart Release System Based on 3D Bioprinted Perfused Scaffold for Vascularized Tissue Regeneration (2016)

A critical challenge to the development of large-scale artificial tissue grafts for defect reconstruction is vascularization of the tissue construct. As an emerging tissue/organ manufacturing technique, 3D bioprinting offers great precision in controlling the internal architecture of a scaffold with preferable mechanical strength and printing complicated microstructures comparable to native tissue. However, current bioprinting techniques still exhibit difficulty in achieving biomimetic nano resolution and cooperating with bioactive spatiotemporal signals. In this study, a comprehensive design of engineered vascularized bone construct is presented for the first time by integrating biomimetic 3D bioprinted fluid perfused microstructure with biologically inspired smart release nanocoating, which is regarded as an aspiring concept combining engineering, biological, and material science. In this biologically inspired design, angiogenesis and osteogenesis are successively induced through a matrix metalloprotease 2 regulative mechanism by delivering dual growth factors with sequential release in spatiotemporal coordination. Availability of this system is evaluated in dynamic culture condition, which is similar to fluid surrounding in vivo, as an alternative animal model study. Results, particularly from co-cultured dynamically samples demonstrate excellent bioactivity and vascularized bone forming potential of nanocoating modified 3D bioprinted scaffolds for human bone marrow mesenchymal stem cells and human umbilical vein endothelial cells.
A receiver/antenna co-design for a 1.5mJ per fix fully-integrated 10×10×6mm<sup>3</sup> GPS logger (2018)

This paper presents an ultra-low-power (ULP) GPS logger system that features a custom miniaturized antenna co-designed with a GPS analog front-end (AFE) optimized for heavy duty-cycling and a 10×10×6mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> form-factor. The complete system includes a GPS AFE, processor, two custom 8Mb flash memory chips, custom antenna, and a 12mAh polymer Li-ion battery. An electrically small differential loop antenna (ka value of 0.24) is designed and all components are integrated on the top and bottom of the antenna in close proximity without degrading the antenna efficiency. In the sleep mode, the processor and the timer consume 50nW and in active mode it draws 12.5mW from a 1.2V supply. The AFE achieves a maximum conversion gain of 72dB, a noise figure of 2.2dB, and P1dB of -46dB. The blocker level that desensitizes the gain by 1dB is -6.1dBm at 1710MHz, one of the closest blockers near the GPS bands. The GPS logger achieves a 10dB SNR after correlation at an input power level of -125dBm. The logger is capable of storing data for 37 position fixes by streaming 10ms of received signal per fix to dual flash memories for later egress and post-processing.
Recognition of Stator Winding Inter-Turn Fault in Interior-Mount LSPMSM Using Acoustic Signals (2020)

This paper presents a novel stator inter-turn fault diagnosis method for Line Start Permanent Magnet Synchronous Motors (LSPMSMs) using the frequency analysis of acoustic signals resulting from asymmetrical faults. In this method, acoustic data are experimentally collected from a 1 hp interior mount LSPMSM for different inter-turn fault cases and motor loading levels, while including the background noise. The signals are collected using a smartphone at a sampling rate of 48,000 samples per second. The signal for each case is analyzed using fast Fourier transform (FFT), which results in the decomposition of the signal into its frequency components. The results indicate that, for both no-load and full-load conditions, 39 components are observed to be affected by the faults, whereby their amplitudes increase with the fault severity. The 40-turns fault shows the highest difference in the component amplitudes compared with the healthy condition acoustic signal. Therefore, this diagnostic method is able to detect the stator inter-turn fault for interior mount LSPMSMs. Moreover, the method is simple and cheap since it uses a readily available sensor.
Fast Failure Handling in Ethernet Networks (2006)

Ethernet is becoming increasingly popular in metro and carrier-grade networks because of its cost-effectiveness, simplicity and scalability. Nevertheless, Ethernet was originally designed as a LAN technology, therefore, it lacks some features, such as fast fault-protection and sophisticated management, which are very important in the new carrier-grade application areas. We propose a simple failure protection mechanism for Ethernet networks that can recover from node and link failures under 50 milliseconds, which is also provided by SDH/Sonet rings. The mechanism relies on a lightweight distributed protocol that runs on IP routers at the edges of the network and works with commodity off-the-shelf Ethernet switches. This paper describes the protocol design and implementation as well as the network testbed implementation for assessing the performance and the robustness of the mechanism. The results collected in the testbed are shown and discussed in the paper.