gebhart/patrepeval huggingface dataset:
Integrated RFA/PSOCT catheter for real-time guidance of cardiac radio-frequency ablation (2018)

Radiofrequency ablation (RFA) is an important standard therapy for cardiac arrhythmias, but direct monitoring of tissue treatment is currently lacking. We demonstrate an RFA catheter integrated with polarization sensitive optical coherence tomography (PSOCT) for directly monitoring the RFA process in real time. The integrated RFA/OCT catheter was modified from a standard clinical RFA catheter and includes a miniature forward-viewing cone-scanning OCT probe. The PSOCT system was validated with a quarter-wave plate while the RFA function of the integrated catheter was validated by comparing lesion sizes with those made with an unmodified RFA catheter. Additionally, the integrated catheter guided catheter-tissue apposition and monitored RFA lesion formation in cardiac tissue in real time. The results show that catheter-tissue contact can be characterized by observing the features of the blood and tissue in the acquired OCT images and that RFA lesion formation can be confirmed by monitoring the change in phase retardance in the acquired PSOCT images. This system demonstrates the feasibility of an integrated RFA/OCT catheter to deliver RF energy and image the cardiac wall simultaneously and justifies further research into use of this technology to aid RFA therapy for cardiac arrhythmias.
Indoxyl Sulfate Serum Level in Chronic Renal Failure Patients detected using Fluorescence-HPLC (2012)

Indoxyl sulfate (IS) is a protein-bound typical uremic toxin that accumulates in patients with impaired kidney function. The laboratory methods used to quantify serum concentrations of IS require improvement. We report an optimal, cost-effective alternative to the methods currently used.The methods is as follows: serum samples were extracted and deproteinized using acetonitrile and then further purified using dichloromethane. The samples were then analyzed using high-performance liquid chromatography (HPLC) with a fluorescence detector at a flow rate of 1.0 mL/min. The isocratic mobile phase consisted of acetonitrile−0.2% (V/V) trifluoroacetic acid in phosphate buffered saline, pH 2.5 (8:92, V/V). Detector settings were λex 280 nm/λem 390 nm. Under the indicated conditions, IS was well separated. The retention time was approximately 6.59±0.11 min. The results of the precision and reproducibility tests were <3%, and the recovery rate was greater than 95%,(98.44±3.21%). In conclusion, HPLC with a fluorescence detector is a simple, sensitive, and reliable method for quantifying IS concentration in the serum of patients with chronic renal failure.
Ordering of characters and strings (1990)

Arranging characters and strings in order of representation codes is not suitabl e for application programming . Even when character ordering is logical, the usual filing o f words in dictionaries does not correspond with the mathematical lexicographic ordering of strings, but some equivalence relation on characters is involved . As a solution to thi s problem, we propose a generic package . The paper also explains the theory behind th e solution . Some definitions of classical mathematics are recalled in the appendix .
Importance of human papillomavirus endemicity in the incidence of cervical cancer: an extension of the hypothesis on sexual behavior. (1994)

The risk of cervical cancer for a woman depends largely on the probability of being infected with some specific types of Human Papillomavirus (HPV). In the control groups of four case-control studies in Colombia and Spain we have shown a strong correlation between the number of sexual partners of males and females and HPV DNA prevalence in the genital tract. Our results suggest that the lifetime number of sexual partners in both sexes are surrogates of the probability of HPV infection and, as such, insufficiently explain the geographical variation in the incidence of cervical cancer. It is proposed that the high rates of cervical cancer in Latin America are linked to the largely unknown characteristics of the HPV endemicity in the population and to the absence of widespread screening for cervical neoplasia. Reliable surveys on the HPV prevalences in selected social groups (i.e., young males and prostitutes) as well as in populations in countries at different risk of cervical cancer are required.
Efficient Resource Sharing in Concurrent Error Detecting Superscalar Microarchitectures (2005)

Previous proposals for soft-error tolerance have called for redundantly executing a program as two concurrent threads on a superscalar microarchitecture. In a balanced superscalar design, the extra workload from redundant execution induces a severe performance penalty due to increased contention for resources throughout the datapath. This paper identifies and analyzes four key factors that affect the performance of redundant execution, namely 1) issue bandwidth and functional unit contention, 2) issue queue and reorder buffer capacity contention, 3) decode and retirement bandwidth contention, and 4) coupling between redundant threads' dynamic resource requirements. Based on this analysis, we propose the SHREC microarchitecture for asymmetric and staggered redundant execution. This microarchitecture addresses the four factors in an integrated design without requiring prohibitive additional hardware resources. In comparison to conventional single-threaded execution on a state-of-the-art superscalar microarchitecture with comparable cost, SHREC reduces the average performance penalty to within 4% on integer and 15% on floating-point SPEC2K benchmarks by sharing resources more efficiently between the redundant threads.
Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations (2009)

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent, resulting in identification of 954 SNPs distributed across nine loci that exceeded the threshold of genome-wide significance, five of which are novel. Overall, the common variants associated with serum uric acid levels fall in the following nine regions: SLC2A9 (p = 5.2x10(-201)), ABCG2 (p = 3.1x10(-26)), SLC17A1 (p = 3.0x10(-14)), SLC22A11 (p = 6.7x10(-14)), SLC22A12 (p = 2.0x10(-9)), SLC16A9 (p = 1.1x10(-8)), GCKR (p = 1.4x10(-9)), LRRC16A (p = 8.5x10(-9)), and near PDZK1 (p = 2.7x10(-9)). Identified variants were analyzed for gender differences. We found that the minor allele for rs734553 in SLC2A9 has greater influence in lowering uric acid levels in women and the minor allele of rs2231142 in ABCG2 elevates uric acid levels more strongly in men compared to women. To further characterize the identified variants, we analyzed their association with a panel of metabolites. rs12356193 within SLC16A9 was associated with DL-carnitine (p = 4.0x10(-26)) and propionyl-L-carnitine (p = 5.0x10(-8)) concentrations, which in turn were associated with serum UA levels (p = 1.4x10(-57) and p = 8.1x10(-54), respectively), forming a triangle between SNP, metabolites, and UA levels. Taken together, these associations highlight additional pathways that are important in the regulation of serum uric acid levels and point toward novel potential targets for pharmacological intervention to prevent or treat hyperuricemia. In addition, these findings strongly support the hypothesis that transport proteins are key in regulating serum uric acid levels.
High-throughput synthesis of azide libraries suitable for direct “click” chemistry and in situ screening (2009)

A key challenge in current drug discovery is the development of high-throughput (HT) amenable chemical reactions that allow rapid synthesis of diverse chemical libraries of enzyme inhibitors. The Cu(I)-catalyzed, 1,3-dipolar cycloaddition between an azide and an alkyne, better known as "click chemistry", is one such method that has received the most attention in recent years. Despite its popularity, there is still a lack of robust and efficient chemical strategies that give access to diverse libraries of azide-containing building blocks (key components in click chemistry). We report herein a highly robust and efficient strategy for high-throughput synthesis of a 325-member azide library. The method is highlighted by its simplicity and product purity. The utility of the library is demonstrated with the subsequent "click" synthesis of the corresponding bidentate inhibitors against PTP1B.
Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia (2008)

Aberrant expression of Aurora kinases and inactivation of wild-type p53 by Mdm2 overexpression are frequent molecular events in acute myelogenous leukemia (AML), and preclinical data for inhibition of Aurora kinases or Mdm2 are promising. However, it remains largely unknown whether the viability of cells exposed to Aurora kinase inhibitors depends on the p53 status. We investigated the interaction of Aurora kinases and p53 pathways after their simultaneous blockades using a small-molecule pan-Aurora kinase inhibitor, MK-0457, and a selective small-molecule antagonist of Mdm2, Nutlin-3. We found that MK-0457, which itself activates p53 signaling, acts synergistically with Nutlin-3 to induce apoptosis in wild-type p53 AML cell lines OCI-AML-3 and MOLM-13 but not in p53-null HL-60 cells. MK-0457 and Nutlin-3 showed synergism in inducing p53, conformational change of Bax and Deltapsi(m) loss, suggesting an involvement of p53-mediated mitochondrial apoptosis. Nutlin-3 constrained endoreduplication after Aurora inhibition via activation of a p53-dependent postmitotic checkpoint and p21 induction in pseudo-G1 cells. Our findings provide the molecular rationale for concomitant targeting of Aurora kinases and Mdm2 in AML where TP53 mutations are rare and downstream p53 signaling is mostly intact.
Container/Closure Integrity Testing and the Identification of a Suitable Vial/Stopper Combination for Low-Temperature Storage at -80  C (2012)

After storage of a live viral vaccine at -80 °C in glass vials closed with rubber stoppers, overpressure in some of the vials was observed, posing a serious safety problem for medical personnel as well as for the product. A working hypothesis to explain this phenomenon involved a possible container closure integrity issue at these low temperatures. The glass transition temperatures (T(g)) of many rubber stopper formulations are in the range -55 to -70 °C. At storage temperatures below T(g), the rubber stopper loses its elastic properties, resulting in compromised seal integrity of the vial and ingress of cold dense gas into the vial headspace. Upon thawing, the rubber stoppers regain their elastic properties and the vials quickly reseal, thereby trapping the ingressed gas, which leads to overpressure in the vial headspace. Nondestructive, laser-based headspace analysis, which is able to detect changes in headspace pressure and gas composition, was used to investigate the maintenance of container closure integrity. Changes in the vial headspace composition and/or pressure are a clear marker for vials that have lost container closure integrity.
Neurofilament light chain as a biomarker in neurological disorders (2019)

In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. New immunoassays able to detect biomarkers at ultralow levels have allowed for the measurement of NfL in blood, thus making it possible to easily and repeatedly measure NfL for monitoring diseases' courses. Evidence that both CSF and blood NfL may serve as diagnostic, prognostic and monitoring biomarkers in neurological diseases is progressively increasing, and NfL is one of the most promising biomarkers to be used in clinical and research setting in the next future. Here we review the most important results on CSF and blood NfL and we discuss its potential applications and future directions.
Neutralization of Pseudotyped Vesicular Stomatitis Virus Expressing Hepatitis C Virus Envelope Glycoprotein 1 or 2 by Serum from Patients (2002)

Infection with hepatitis C virus (HCV) generally progresses to chronic disease, although a minority of patients appear to clear viremia spontaneously. In this investigation, serum samples were analyzed for virological parameters, serum alanine aminotransferase (ALT) levels, and neutralizing antibody response against pseudotyped vesicular stomatitis virus (VSV) generated using chimeric envelope glycoprotein 1 (E1) or 2 (E2) of HCV. Testing of sequential serum samples that were collected beginning at the onset of acute-phase disease demonstrated intermittent viremia, elevated ALT levels, and detectable neutralization activity against VSV in 9 of 10 patients. Serum neutralization activity did not exhibit a correlation with the genotype of the infecting HCV or with virus load. On the other hand, patients with chronic HCV infection consistently had detectable amounts of virus present but no significant variation in ALT levels, and serum samples from a majority (>90%) of patients failed to show detectable neutralization activity.
Experimental characterization and quadratic programming-based control of brushless-motors (2003)

A new torque control strategy for brushless motors is presented, which results in minimum torque ripple and copper losses. The motor model assumes linear magnetics, but contains a current limit which can delimit the onset of magnetic saturation, or be the motor amplifier current limit, whichever is reached first. The control problem is formulated and solved as a quadratic programming problem with equality and inequality constraints to find the nonlinear mapping from desired torque and position to the motor's phase currents. The optimal solution is found in closed form using the Kuhn-Tucker theorem. The solution shows that, unlike the conventional commutation with a fixed current-position waveform, the waveforms of the proposed controller vary in order to respect the current limitation in one phase by boosting the current in the other phases. This increases the maximum torque capability of the motor - in our particular system by 20% - compared to fixed waveform commutation. Experimental data from our brushless direct-drive motor demonstrates that the controller produces virtually ripple-free torque and enhances remarkably the tracking accuracy of the motion controller.
Randomized trial of Tibetan yoga in breast cancer patients undergoing chemotherapy. (2014)

9539 Background: Mind-body practices improve quality of life (QOL), yet prior trials have not included active control groups. Our prior work found a Tibetan Yoga Program (TYP) resulted in fewer sleep disturbances. This study assessed the effects of TYP versus Stretching Program (STP) and Usual Care (UC) on sleep, fatigue and QOL of breast cancer patients undergoing chemotherapy. Methods: Patients with stage I-III breast cancer undergoing chemotherapy were eligible. Participants were randomized to TYP, STP or UC. TYP and STP consisted of four 90-minute sessions. TYP consisted of controlled breathing, visualization, meditation and postures. STP included common stretches for recovery and mirrored TYP postures. Sleep disturbances (PSQI), fatigue (BFI) and breast cancer-specific QOL (FACT-B) were assessed at baseline, 1 week and 1 and 6 months after the last session. Results: Participants were 283 women (mean age=48.8 years). We analyzed participants who completed baseline and at least one follow-up with GLM, controlling for corresponding baseline measures and age, menopausal status, stage, time since diagnosis, surgical procedure and chemotherapy regimen. Analyses revealed a significant group main effect at 6-months post-intervention for sleep duration (means: TYP=0.85; STP=1.33; UC=1.21; p=0.02), with TYP reporting greater sleep duration than STP (p=0.008) and UC (p=0.02). Similar results were found for sleep efficiency (means: TYP=1.57; STP=2.17; UC=2.29; p=0.06), with TYP being significantly different from UC (p=002). There were no significant group differences for BFI. For FACT-B, there was a significant group effect at 1-week post-intervention (means: TYP=12.5; STP=14.3; UC=13.9; p=0.05), with TYP reporting fewer symptoms than STP (p=0.02) and UC (marginal at p=0.06). At 3-months post-intervention, there was a significant group effect for FACT-B (means: TYP=7.9; SG=10.5; UC=8.7; p=0.04), with group differences between TYP and STP (p=0.01). Conclusions: Participating in a Tibetan yoga program resulted in better long-term sleep quality and QOL than an active control intervention or usual care. Tibetan yoga should be considered to help improve these symptoms for breast cancer patients undergoing chemotherapy. Clinical trial information: NCT00507923.
Telco Churn Prediction with Big Data (2015)

We show that telco big data can make churn prediction much more easier from the $3$V's perspectives: Volume, Variety, Velocity. Experimental results confirm that the prediction performance has been significantly improved by using a large volume of training data, a large variety of features from both business support systems (BSS) and operations support systems (OSS), and a high velocity of processing new coming data. We have deployed this churn prediction system in one of the biggest mobile operators in China. From millions of active customers, this system can provide a list of prepaid customers who are most likely to churn in the next month, having $0.96$ precision for the top $50000$ predicted churners in the list. Automatic matching retention campaigns with the targeted potential churners significantly boost their recharge rates, leading to a big business value.
Human bile salt‐stimulated lipase has a high frequency of size variation due to a hypervariable region in exon 11 (2002)

The apparent molecular mass of human milk bile salt-stimulated lipase (BSSL) varies between mothers. The molecular basis for this is unknown, but indirect evidence has suggested the differences to reside in a region of repeats located in the C-terminal part of the protein. We here report that a polymorphism within exon 11 of the BSSL gene is the explanation for the molecular variants of BSSL found in milk. By Southern blot hybridization we analyzed the BSSL gene from mothers known to have BSSL of different molecular masses in their milk. A polymorphism was found within exon 11, previously shown to consist of 16 near identical repeats of 33 bp each. We detected deletions or, in one case, an insertion corresponding to the variation in molecular mass of the BSSL protein found in milk from the respective woman. Furthermore, we found that 56%, out of 295 individuals studied, carry deletions or insertions within exon 11 in one or both alleles of the BSSL gene. Hence, this is a hypervariable region and the current understanding that exon 11 in the human BSSL gene encodes 16 repeats is an oversimplification and needs to be revisited. Natural variation in the molecular mass of BSSL may have clinical implications.
Kinetics of phase variation between S and type-1 fimbriae of Escherichia coli (1985)

The rate of fimbrial phase variation in Escherichia coli strain 3040 was determined. The strain has type-1 and S fimbriae. The bacterial culture was fractionated into homogeneous subpopulations expressing either one of the fimbrial types only; the subpopulations were inoculated into broth and the fimbriation of individual cells was assayed by immunofluorescence as a function of time. The rate of the shift from S- or type-1-fimbriate cells to non-fimbriate ones was of the order of 10−2 per cell generation and more rapid than a direct shift from one fimbrial phase to another, although both types of phase variations were observed.
C5L2, a Nonsignaling C5A Binding Protein (2003)

C5a anaphylatoxin, a potent inflammatory mediator, is known to act through a specific G protein coupled receptor. However, some of the complex effects of C5a in vivo may not be explained solely by the deletion of the known receptor. Here, we show that an orphan receptor, identified as C5L2, is a high affinity C5a binding protein. Unlike the previously described C5aR, C5L2 is obligately uncoupled from heterotrimeric G proteins, in part by virtue of an amino acid alteration in the so-called DRY sequence at the end of the third transmembrane segment. Both human and murine C5L2 bear a leucine for arginine replacement at this site. C5L2, when transfected into several cell types, is weakly phosphorylated in transfected cells following binding of C5a but does not induce significant activation of MAP kinases, mediate calcium flux, or stimulate chemotaxis. Bone marrow cells from wild type respond robustly to C5a with induction and suppression of a number of inflammation related genes. In contrast, C5a receptor deficient mice, which bear C5L2 alone, do not respond to C5a with changes in gene transcription by microarray analyses. Biophysical properties of the C5L2, including slow ligand on and off rates, absence of internalization, and relatively high affinity for the C5a des Arg metabolite, suggest that this receptor may serve to modulate C5a biological functions in vivo. Finally, in contrast to previous reports, we find absolutely no interaction of C5L2 with other anaphylatoxins C3a and C4a.
Stereospecific palladium-promoted oxyamination of alkenes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific palladium-promoted oxyamination of alkenesJan E. Baeckvall and Eva E. BjoerkmanCite this: J. Org. Chem. 1980, 45, 14, 2893–2898Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/jo01302a028https://doi.org/10.1021/jo01302a028research-articleACS PublicationsRequest reuse permissionsArticle Views535Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: 1‐Methyl‐4‐substituted‐1H‐pyrazolo(3,4‐b)pyridine‐5‐carboxylic Acid Derivatives: Effect of Structural Alterations on Activity at A1 and A2 Adenosine Receptors. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.