gebhart/patrepeval huggingface dataset:
Energy-Efficient Baseband Unit Placement in a Fixed/Mobile Converged WDM Aggregation Network (2014)

Energy efficiency is expected to be a key design parameter for next-generation access/aggregation networks. Using a single network infrastructure to aggregate/backhaul both mobile and fixed network traffic, typically referred to as fixed/mobile convergence (FMC), seems a promising strategy to pursue energy efficiency. WDM networks are a prominent candidate to support next-generation FMC network architectures, as they provide huge capacity at relatively low costs and energy consumption. We consider a FMC WDM aggregation network in which the novel concept of “hotelling” of mobile baseband units (BBUs) is employed. The so-called BBU hotelling consists in separating BBUs from their cell sites and consolidating them in single locations, called hotels. As a result, the aggregation network will transport both IP (fixed and mobile) traffic and CPRI (fronthaul) traffic, the latter exchanged between each BBU and its cell site. In this paper, we propose an energy-efficient WDM aggregation network, and we formally define the BBU placement optimization problem, whose objective is to minimize the defined aggregation infrastructure power (AIP). We consider three different network architectures: Bypass, Opaque, and No-Hotel, which feature different placement of BBUs and routing of traffic. By modeling the power contributions of each active device, we study how and how much BBU consolidation, optical bypass, and active traffic aggregation influence the AIP, for all the three architectures. Our results show that, in our case study, the proposed architectures enable savings up to about 60%-65% in dense-urban/urban and about 40% in rural scenarios.
Staged Method of Code Similarity Analysis for Firmware Vulnerability Detection (2019)

The security situation of the Internet of Things (IoT) is more serious than ever, and there is an urgent need to detect and patch device vulnerability rapidly. With the astronomical numbers of IoT devices, it is very difficult to execute regular security inspections. Existing vulnerability detection technology based on simple feature matching cannot reach high accuracy to detect firmware vulnerabilities while using a control flow graph matching directly has proven to be too expensive. To address the problem of accurate and efficient, we present a method of staged firmware vulnerability detection based on code similarity. The first stage, function embedding based on neural network is used to analyze the similarities among functions, and large-scale firmware security inspection can be achieved efficiently. The second stage, the similarity among function local call flow graphs is calculated for fine-grained firmware security analysis, and this stage can improve the accuracy of vulnerability detection. We compared our method with state-of-the-art approaches, and the experimental results demonstrate that our method is more accurate. The average retraining time of our method is 1 h, and the real-world firmware vulnerability detection experiment of our method demonstrates that the true positive rate of the top 30 is as high as 86%.
Measurement of a Brønsted Nucleophile Coefficient and Insights into the Transition State for a Protein Tyrosine Kinase (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMeasurement of a Brønsted Nucleophile Coefficient and Insights into the Transition State for a Protein Tyrosine KinaseKyonghee Kim and Philip A. ColeView Author Information Laboratory of Bioorganic Chemistry The Rockeller University 1230 York Avenue, New York, New York 10021Cite this: J. Am. Chem. Soc. 1997, 119, 45, 11096–11097Publication Date (Web):November 12, 1997Publication History Received26 June 1997Published online12 November 1997Published inissue 1 November 1997https://pubs.acs.org/doi/10.1021/ja972110khttps://doi.org/10.1021/ja972110krapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views823Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Monomers,Peptides and proteins,Substitution reactions,Transition states Get e-Alerts
In-Vitro and Predicted In-Vivo Performances of a Pneumatically Regulated Artificial Ventricle (1977)

An all-pneumatic driving system is presented which provides close duplication of the Starling’s cardiac regulation function to an artificial left ventricle in mock circulation. The system, built from commercially available fluid operated devices, uses atrial pressure feedback to adjust the ventricle pumping air pressure, with the aid of a hydraulic/pneumatic pressure transducer developed especially for the application. A simple linear mathematical model for the physiological circulatory system is used to compare the simulated in-vivo performance of the system with Starling’s response of the natural left heart for different systemic resistances and compliances. The model is valid for output flows from 1 to 10 l/min and atrial pressure from 1 to 8 mmHg. It shows close agreement in ventricle output, arterial and atrial pressure changes between the artificial ventricle and the natural left heart for systemic resistance changes from about 5 × 104 to 5 × 105 kN-s/m5 and for typical venous to arterial compliance ratios of 24 to 37.
Pien Tze Huang Protects the Liver against Carbon Tetrachloride‐Induced Damage (2002)

Pien Tze Huang, a traditional Chinese medicine, has been extensively used as a therapeutic drug in the treatment of liver diseases. In this study, we have examined its ability to protect the liver from carbon tetrachloride (CCl4)-induced damage in the mouse. Histological observations revealed that CCl4 treatment induced extensive degenerative changes in the hepatocytes surrounding the central veins of the liver. However, these changes were much reduced by more than 28% in mice fed with 0.5 mg of Pien Tze Huang/g body weight/dose (3 doses over 36 hr) prior to CCl4 treatment. The effects of Pien Tze Huang were then further investigated in a hepatoma cell line. Flow analysis showed that it had no significant effects on cell proliferation. When the ability of Pien Tze Huang to influence various response elements of important signal transduction pathways was examined in the hepatoma cell line, it was found that Pien Tze Huang stimulated an increase in the response of AP1, CRE and NFkappaB responsive elements. The transcriptional factors of these responsive elements are known to play important roles in regulating cell death and survival. We thus postulate that the ability of Pien Tze Huang to protect the liver from damage is attained through its ability to modulate the activity of these important signal transduction pathways.
A Short Enantioselective Access to Pumiliotoxin 251D from L-Proline (1996)

Le squelette indolizidinique de la pumiliotoxine 251D possedant les fonctionnalites necessaires a l'introduction de l'alcool tertiaire en C-8 et de la chaine laterale alkylidene en C-6 a ete synthetise a partir de la L-proline via une reaction de cyclisation radicalaire 6-exo-dig.
Dehydrocoupling routes to element–element bonds catalysed by main group compounds (2015)

Dehydrocoupling reactions, i.e. reactions involving elimination of H2 between two E-H bonds, provide a clean route to E-E bonds within the main group. The products afforded from these reactions have applications in organic synthesis and materials chemistry, and in addition the H2 released during these reactions can also be useful as an energy source. Previous methods for dehydrocoupling involve both thermal and transition metal catalysed routes but recent developments have shown that main group compounds can be used as catalysts in these reactions. This tutorial review will focus on the development of main group catalysed dehydrocoupling reactions as a route to heteronuclear element-element bonds.
Modelling and identification for fault diagnosis: a new paradigm (2002)

A novel modelling, and identification scheme for real time fault diagnosis is proposed. A diagnostic model for the system is developed which consists of a) an input-output difference equation model expressed explicitly in terms of the feature vector (which is a vector formed of the coefficients of a transfer function model) and data vector (vector formed present and past inputs and the past outputs) and b) a matrix, termed multilinearity matrix, relating the diagnostic parameter (a vector formed of the coefficients of a transfer function of a functional unit) and the feature vector. A scheme to identify the diagnostic model in the face of model uncertainties, the noise and the disturbances is proposed.
Shared Authority Based Privacy-Preserving Authentication Protocol in Cloud Computing (2014)

Cloud computing is an emerging data interactive paradigm to realize users’ data remotely stored in an online cloud server. Cloud services provide great conveniences for the users to enjoy the on-demand cloud applications without considering the local infrastructure limitations. During the data accessing, different users may be in a collaborative relationship, and thus data sharing becomes significant to achieve productive benefits. The existing security solutions mainly focus on the authentication to realize that a user’s privative data cannot be illegally accessed, but neglect a subtle privacy issue during a user challenging the cloud server to request other users for data sharing. The challenged access request itself may reveal the user’s privacy no matter whether or not it can obtain the data access permissions. In this paper, we propose a shared authority based privacy-preserving authentication protocol (SAPA) to address above privacy issue for cloud storage. In the SAPA, 1) shared access authority is achieved by anonymous access request matching mechanism with security and privacy considerations (e.g., authentication, data anonymity, user privacy, and forward security); 2) attribute based access control is adopted to realize that the user can only access its own data fields; 3) proxy re-encryption is applied to provide data sharing among the multiple users. Meanwhile, universal composability (UC) model is established to prove that the SAPA theoretically has the design correctness. It indicates that the proposed protocol is attractive for multi-user collaborative cloud applications.
A low complexity physical-layer identity detection for 3GPP Long Term Evolution (2010)

Long Term Evolution (LTE) is one of radio access technology that has been intensively studied in 3GPP standard group to support instantaneous downlink and uplink peak data rates of 100Mb/s and 50Mb/s within 20 MHz downlink and uplink spectrum allocations, respectively. Employing OFDMA and scalable bandwidth scheme in downlink access impact on increasing cell search complexity. In this paper we propose low complexity physical layer identity detection as one of cell search step using finite impulse response (FIR) and partial cross-correlation. Our propose scheme is done in time domain instead of frequency to avoid FFT involvement and decrease processing latency. As a result, the proposed scheme just needs 20169 LUTs when implemented in FPGA Virtex-4 XC4VLX200 and can perform physical layer identity detection for SNR 0dB or higher in AWGN channel by probability more than 95%.
Purification and characterization of a regiospecific lipase from Aspergillus terreus. (1998)

Aspergillus terreus lipase was purified to homogeneity with 18.0% yield. The specific activity of the enzyme increased from 20.80 to 250 U/mg of protein. Ion exchange on Q-Sepharose was highly effective in the purification process. The molecular mass of the purified enzyme was 41+/-1 kDa as determined by SDS/PAGE. The purified lipase showed excellent temperature tolerance (15-90 degreesC) and was highly thermostable, retaining 100% activity at 60 degreesC for 24 h. It showed good pH tolerance (3.0-12.0) and was stable over a pH range of 4.0-10.0 for 24 h. The activity of the enzyme was inhibited by ionic detergents, whereas non-ionic detergents stimulated enzyme activity. Mg2+ and Ca2+ ions stimulated lipase activity, whereas Co2+, Cu2+, Ni2+ and Fe3+ ions caused inhibition. The enzyme was unaffected by the metal chelator EDTA or by 2-mercaptoethanol and potassium ferrocyanide. At a concentration of 100 microM, 3,4-dichloroisocoumarin caused weak inhibition with 40% loss of activity, but diethyl p-nitrophenyl phosphate at the same concentration strongly inhibited enzyme activity (98.12% loss of activity), confirming that the A. terreus lipase is a serine hydrolase. The lipase was highly active on pig fat (151% relative activity) and groundnut oil (103% relative activity) and least active on kusum oil (18% relative activity). Extensive dialysis did not affect enzyme activity up to 168 h, suggesting the absence of any dialysable cofactor in the enzyme. The A. terreus lipase retained significant activity on freeze-drying and had a shelf-life of more than 6 months at room temperature. The A. terreus lipase exhibited 1,3-regiospecificity and was stable in various organic solvents.
Cytochrome P450 responsible for the stereoselective S-oxidation of flosequinan in hepatic microsomes from rats and humans. (1997)

The forms of cytochrome P450 involved in the stereoselective S-oxidation of flosequinan [(+/-)-7-fluoro-1-methyl-3-methylsulfinyl-4-quinolone] were investigated in vitro using liver microsomes from rats and humans. Rat liver microsomes supplemented with NADPH catalyzed the four different S-oxidations, which were from flosequinan sulfide (FS; 7-fluoro-1-methyl-3-methylthio-4-quinolone) to R(+)- and S(-)-flosequinan (R-FSO and S-FSO, respectively) and from R-FSO and S-FSO to flosequinan sulfone (FSO2; 7-fluoro-1-methyl-3-methylsulfonyl-4-quinolone). The activities of all the S-oxidases in liver microsomes from male rats were higher than those from female rats. The activities of the S-oxidases measured at a high substrate concentration (1 mM) were induced by treatment of rats with phenobarbital and dexamethasone. Treatment of rats with 3-methylcholanthrene also induced the activities, but only at a low substrate concentration (50 microM), except for the S-oxidase catalyzing the reaction from FS to R-FSO. Enzymes induced by clofibrate and ethanol were not involved in the oxidations at a low substrate concentration. The activities of S-oxidases were correlated with the contents of cytochrome P450 (CYP)3A enzymes. Anti-CYP3A2 antisera inhibited the activities of the S-oxidases catalyzing the reactions from FS to R-FSO (40%) and to S-FSO (60%) at the high substrate concentration and inhibited the activities of the S-oxidases, thus catalyzing reactions from R-FSO and S-FSO to FSO2 (70%) at both high and low substrate concentrations. These results suggest that CYP3A is the major enzyme involved in all S-oxidation pathways in flosequinan metabolism in rats. On the other hand, except for the S-oxidation of FS to R-FSO, the rates of the other three S-oxidations by liver microsomes from 30 individual humans correlated highly with each other, suggesting that the same enzyme would be involved in the three S-oxidations. Anti-CYP3A2 antisera inhibited the activities of all the S-oxidases in human liver microsomes ranging from 40 to 80%, suggesting that CYP3A is also involved in all of the S-oxidations of flosequinan in humans.
Successful transgene expression with serial doses of aerosolized rAAV2 vectors in rhesus macaques (2003)

Bronchoscopic microspraying of recombinant adeno-associated viral (rAAV) vectors targets high doses of vector directly to pulmonary epithelium. Single-dose endobronchial gene therapy trials have been accomplished in cystic fibrosis patients; however, repeated dosing strategies are likely essential for lifetime correction. These studies address whether serial redosing with rAAV2 vectors results in an antiserotypic response and, furthermore, whether it triggers an inflammatory response prohibitive to transgene expression. Serial redosing of 9 x 10(11) infectious units of aerosolized rAAV2 vectors to rhesus macaques resulted in successful gene transfer by quantitative PCR (1.43 x 10(9) copies/g tissue) and transgene expression. Additionally, confocal microscopy and immunohistochemical analysis demonstrated in situ expression localized to the pulmonary epithelium. Although serial redosing did induce a heightened anti-neutralizing antibody response in sera, gene transfer prevailed with resultant expression. This study is the first to demonstrate successful gene transfer subsequent to repeated aerosolized doses of rAAV2 in immunocompetent nonhuman primates without associated inflammatory responses prohibitive to transgene expression.
Combining Dynamic Stretch and Tunable Stiffness to Probe Cell Mechanobiology In Vitro (2011)

Cells have the ability to actively sense their mechanical environment and respond to both substrate stiffness and stretch by altering their adhesion, proliferation, locomotion, morphology, and synthetic profile. In order to elucidate the interrelated effects of different mechanical stimuli on cell phenotype in vitro, we have developed a method for culturing mammalian cells in a two-dimensional environment at a wide range of combined levels of substrate stiffness and dynamic stretch. Polyacrylamide gels were covalently bonded to flexible silicone culture plates and coated with monomeric collagen for cell adhesion. Substrate stiffness was adjusted from relatively soft (G' = 0.3 kPa) to stiff (G' = 50 kPa) by altering the ratio of acrylamide to bis-acrylamide, and the silicone membranes were stretched over circular loading posts by applying vacuum pressure to impart near-uniform stretch, as confirmed by strain field analysis. As a demonstration of the system, porcine aortic valve interstitial cells (VIC) and human mesenchymal stem cells (hMSC) were plated on soft and stiff substrates either statically cultured or exposed to 10% equibiaxial or pure uniaxial stretch at 1 Hz for 6 hours. In all cases, cell attachment and cell viability were high. On soft substrates, VICs cultured statically exhibit a small rounded morphology, significantly smaller than on stiff substrates (p<0.05). Following equibiaxial cyclic stretch, VICs spread to the extent of cells cultured on stiff substrates, but did not reorient in response to uniaxial stretch to the extent of cells stretched on stiff substrates. hMSCs exhibited a less pronounced response than VICs, likely due to a lower stiffness threshold for spreading on static gels. These preliminary data demonstrate that inhibition of spreading due to a lack of matrix stiffness surrounding a cell may be overcome by externally applied stretch suggesting similar mechanotransduction mechanisms for sensing stiffness and stretch.
CytoSPADE: high-performance analysis and visualization of high-dimensional cytometry data (2012)

Additional documentation available at http://cytospade.org.
Adaptive dynamic inversion for nonaffine-in-control systems via time-scale separation: part II (2005)

This paper presents an adaptive dynamic inversion method for uncertain nonaffine-in-control dynamical systems. Online approximation of the adaptive dynamic inversion controller is performed using time-scale separation. The resulting control signal is sought as a solution of a "fast" dynamical equation, which inverts a series parallel model, whose state is shown to track the state of the original nonaffine-in-control system. Numerically verifiable sufficient conditions on the system parameters are given. A simulation example illustrates the theoretical results.
Modelling and estimation of friction brake torque for a brake by wire system (2014)

Recent advances in the automotive industry have incorporated the latest technology in vehicle electrification, with the aim to reduce fuel consumption, pollutants emissions, as well as enhance vehicle performance and safety. As a result, Electric Vehicles (EV) and Hybrid Electric Vehicles (HEV) have become the imminent automotive future, establishing important challenges in vehicle systems integration and control. In these vehicles, the regenerative braking is currently the major technique of energy recovery, providing accurate control on the brake torque applied. However regenerative brakes still need the support of conventional friction brakes, mainly due to the battery limitations. Consequently, the coordination of both braking strategies becomes critical for the safe actuation of braking related systems such as: ABS and ESP. Unfortunately, the torque blending between friction and regenerative brakes is a complicated task due to the different systems inputs; the regenerative brakes receive torque inputs, whilst the friction brakes work with pressure inputs. This paper proposes the friction brake torque estimation to simplify the torque blending, and improve the energy recovery and driving safety. The brake torque is estimated not only considering the pressure developed at the calipers, but also the brake disc temperature, and the wheel speed effect on the friction coefficient. The torque is obtained without installing additional sensors in the vehicle platform, considering that only wheel speed sensors are available. The estimation is performed using the extended version of the Kalman Filter. The results obtained are very satisfactory, and can improve the performance of the named systems in a safe way.