gebhart/patrepeval huggingface dataset:
eCAD: a knowledge-based course engineering system (2004)

Colleges and universities have increasingly migrated towards utilizing the World Wide Web to convey at least a part and, in many cases, their entire curricular offering. Despite this trend, there is inadequate support for the professors responsible for restructuring the courses they have refined over a career in the classroom for delivery via the Web. Teachers who are expert in their subject area and masters of their craft when in a classroom find themselves in the uncomfortable position of having to relearn how to teach in a new environment with little or no support. The process of planning and developing a course for delivery in an online environment is, in many significant aspects, analogous to the processes required to develop a software system. Both situations require the developer to manage resources through a series of steps with the goal of designing a product that effectively utilizes the computer to solve a problem. The procedures and tools used in software engineering to manage software system development, therefore, offer promise for developing online courses. Computer aided software engineering (CASE) tools are of special interest by virtue of the support afforded the development process through computerization. This paper offers an architectural overview of a knowledge-based, course engineering system: eCAD (electronic Course Analysis & Design). The requirements for the system, the manner in which those criteria were developed and validated, and system design are detailed. A working prototype is also presented.
Assessment of Naturalistic Use Patterns of Advanced Infotainment Systems (2014)

These data provide a comparison basis for use in examining driver interactions with future infotainment systems.
Screening USDA Lettuce (Lactuca sativa L.) Germplasm for Ability to Germinate under Cold Conditions (2015)

Low temperatures can slow down emergence, decrease weed competitiveness, and lead to uneven crop maturity in direct-seeded crops such as baby leaf lettuce ( Lactuca sativa L.). In this study, seeds of 103 single-parent lineage, homozygous lettuce accessions (53 cos and 50 leaf type) from the USDA National Plant Germplasm System (NPGS) and six commercial standard lettuce cultivars (three cos and three leaf type) were evaluated in replications for percent germination after 7 and 10 days at 5 °C in a germination chamber. Cos and leaf types were selected for this study as they are most commonly used for baby leaf lettuce production. Differences were observed among entries in percent seeds germinated after both 7 and 10 days. Overall, an average of 68% of seeds germinated after 7 days and 94% germinated after 10 days. Although several NPGS accessions had higher percent germination than the commercial cultivars, the average percent germination was not statistically different between the two seed sources at 7 or 10 days. Percent germination also did not differ between entries of cos and leaf type after 7 or 10 days. Similarly, no difference in percent germination between entries of dark and white seed color was observed after 7 or 10 days. No relationship between 100 seed weight and percent germination was observed after 7 days ( r 2 = 0.07) or 10 days ( r 2 = 0.13). Thus, lettuce seed type, color, and 100 seed weight do not appear to be good predictors of germination under cold conditions in lettuce. The accessions with the highest percent germination after 7 days at 5 °C have the potential to be used for the development of new lettuce cultivars suitable for an extended, early season production in temperate climates when soil temperature is lower than optimal for lettuce germination. Further studies are needed to assess the ability of these accessions to germinate rapidly under cold field soil conditions.
A highly tunable 65-nm CMOS LIF neuron for a large scale neuromorphic system (2016)

We present the design and measurement of a continuous-time, accelerated, reconfigurable Leaky Integrate and Fire (LIF) neuron model emulated in 65-nm CMOS technology. The neuron circuit is designed as a sub-circuit of our highly integrated neuromorphic prototype chip, the “HICANN-DLS”. The design is geared towards testability and debug features, as well as area and power efficiency. Each neuron in the array integrates current from a multitude of input synapses onto an RC integrator within the synaptic input sub-circuit, where a variable resistor tunes the synaptic time constant. Linear transconductors convert voltage into an equivalent current as well as modeling the leak term, while a pulse generator circuit evokes a digital spike event. Our measurements show that the neuron successfully integrates input synaptic events ranging from a few nA to greater than 10 µA and tunes a wide range of tunable synaptic and membrane time constants. A higher membrane dynamic range of up to 1100 mV, and longer refractory times can be achieved, operating 1000 times faster than biological real-time. The design of the neuron simplifies calibration and reduces the mismatch, as multiple die measurements indicate. We demonstrate a one-to-one correspondence to software simulation for a typical computational model neuron. Due to the wide tunable range, the neuron is to be our general-purpose element of our second generation flexible neuromorphic platform for a variety of computational models.
Asian Chemical Congress, 23-25 August 2007 (2007)

The Asian Chemical Congress (ACC) will be held at Kuala Lumpur in August 2007 and the main goal of the RACI International Relations Committee (IRC) is to raise Australian participation in the ACC series. The IRC invites eminent Australian and international scientists as both organisers and keynote speakers at the symposium.
Automated Fluidic System with a Chaotic Microfluidic Reaction Chamber for Rapid, Multi-Analyte Immunosensing (2007)

In this paper, a fully automated fluidic system with a chaotic reaction chamber for rapid and accurate fiber-optic immuno-sensing has been developed and applied for the measurement of cardiac biomarkers. A new microchannel with serpentine bump structures has improved the sensor performance by generating local turbulence near the sensor surface. A full immunoassay with the automated fluidic system has been successfully performed, and the total assay time spent for detecting four cardiac markers was less than 10 minutes.
A New Method for Image Compression and Progressive Transmission (1990)

報告番号: 甲08755 ; 学位授与年月日: 1990-09-29 ; 学位の種別: 課程博士 ; 学位の種類: 理学博士 ; 学位記番号: 博理第2309号 ; 研究科・専攻: 理学系研究科情報科学専攻
AGNIQUE AMD 3L as green solvent for polyethersulfone ultrafiltration membrane preparation (2019)

ABSTRACT With the advent of the green chemistry concept novel, innocuous, biodegradable solvents require introduction in industrial processes. N , N ‐dimethyl lactamide (AGNIQUE AMD 3L) represents a bio‐based, biodegradable, label‐free polar, protic solvent. In this article, AGNIQUE AMD 3L is introduced as novel solvent for preparation of polyethersulfone (PESU) nonsolvent‐induced phase separation ultrafiltration membranes using polyvinylpyrrolidone or poly(ethylene oxide) as second dope additives. Analysis of Hansen solubility parameters indicates good solvent–polymer interactions for polymer dope compositions required for PESU membrane manufacturing. Depending on the process conditions, PESU ultrafiltration membranes with hydraulic permeability values up to 610 kg m −2 × bar × h and molecular weight cutoff value of 20 kDa were obtained. Scanning electron microscope of membrane cross sections reveals perfect defect‐free, asymmetric morphologies. As a result, AGNIQUE AMD 3L provides a new alternative as replacement for polar, aprotic solvents employed in membrane manufacturing so far. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48419.
Polyamines and neoplastic growth (2007)

Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review summarizes recent work on the regulation of putrescine production both de novo and via the degradation of higher polyamines and provides a summary of studies using transgenic mice in which the levels of proteins that regulate these processes (L-ornithine decarboxylase, antizyme and spermidine/spermine-N(1)-acetyltransferase) are altered.
Identification of some antibacterial constituents of New Zealand manuka honey (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIdentification of some antibacterial constituents of New Zealand manuka honeyK. M. Russell, P. C. Molan, A. L. Wilkins, and P. T. HollandCite this: J. Agric. Food Chem. 1990, 38, 1, 10–13Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jf00091a002https://doi.org/10.1021/jf00091a002research-articleACS PublicationsRequest reuse permissionsArticle Views1149Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Constitutive Glucose Transport in Rat Leydig Cells and Pyruvate Support of Steroidogenesis (1988)

To facilitate the interpretation of in vitro experiments that use pharmacological agents, such as cytochalasin B, which inhibits glucose transport, an alternative to glucose as an energy source for rat Leydig cells was sought. Pyruvate was superior to glucose as an energy source for the support of steroidogenesis. The concentration of pyruvate required to support half-maximum androgen production was lower than that for glucose (60 +/- 8 versus 478 +/- 87 microM, respectively), and pyruvate supported a higher rate of maximum LH-stimulated androgen production. The latter result suggested that glucose availability can be rate limiting for steroidogenesis in in vitro experiments. The acute regulation of glucose transport was therefore investigated using 2-Deoxy-D-[2,6(3)H]glucose. Uptake of 2-Deoxy-D-[2,6(3)H]glucose by Leydig cells was not affected by insulin, LH, or glucose deprivation, suggesting that it is a constitutive process in these cells.
A Path-Sensitive Control Flow Graph (2010)

Control Flow Graph (CFG) is a compact representation of all executable paths of a program and it is central to most program analyses. Unfortunately, the direct use of a CFG has two major sources of imprecision: (a) the existence of infeasible paths, and (b) the merging of states along incoming edges of a control-flow merge. Addressing these two problems is the path-sensitivity issue, and it is a folklore that path-sensitive analyses are more accurate. In this paper, we present a method to systematically restructure a CFG in order to encode path-sensitivity into it. The path-sensitive CFG is generated from the symbolic execution tree by (a) removing infeasible paths, and (b) duplicating subgraphs when it is likely to produce more accurate results by the underlying analyzer. We use constraint solving to test path infeasibility. To produce a graph of manageable size, we systematically generalize the state associated with a tree node while preserving its reason of infeasibility. This increases the likelihood of subsuming other nodes. If a node is subsumed then it is merged together with its subsumer. Otherwise, our method splits the subsumer and the subsumed nodes. The above transformation is done offline and independent to the analysis. We finally present experimental data on real benchmarks that shows the efficiency and effectiveness of the approach. 1.
Inhibition of restriction enzyme cleavage of DNA modified with 7-deaza-dGTP (1991)

Journal Article Inhibition of restriction enzyme cleavage of DNA modified with 7-deaza-dGTP Get access S.K. Grime, S.K. Grime Boehringer Mannheim Corp., Biochemical Products DivisionIndianapolis, IN 46250, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar R.L. Martin, R.L. Martin Boehringer Mannheim Corp., Biochemical Products DivisionIndianapolis, IN 46250, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar B.L. Holaway B.L. Holaway * Boehringer Mannheim Corp., Biochemical Products DivisionIndianapolis, IN 46250, USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 10, 11 May 1991, Page 2791, https://doi.org/10.1093/nar/19.10.2791 Published: 25 May 1991 Article history Accepted: 20 March 1991 Published: 25 May 1991
Face Recognition: A Literature Review (2008)

The task of face recognition has been actively researched in recent years. This paper provides an up-to-date review of major human face recognition research. We first present an overview of face recognition and its applications. Then, a literature review of the most recent face recognition techniques is presented. Description and limitations of face databases which are used to test the performance of these face recognition algorithms are given. A brief summary of the face recognition vendor test (FRVT) 2002, a large scale evaluation of automatic face recognition technology, and its conclusions are also given. Finally, we give a summary of the research results.
A High-Performance Anode-Supported SOFC with LDC-LSGM Bilayer Electrolytes (2004)

An anode-supported solid oxide fuel cell (SOFC) with lanthanum-doped ceria (LDC) and strontium and magnesium doped lanthanum gallate (LSGM) bilayer electrolytes was fabricated and tested. The bilayer electrolyte thin film, consisting of a 25 mum thick LDC layer and a 75 mum thick LSGM layer, was prepared by a simple dry-pressing process. The two electrolyte layers were sintered together well, and no crack and peel-off at the interface were observed. An open-circuit potential of 1.02 V and a maximum power density of over 1.1 W/cm(2) was achieved with H-2 as fuel and air as oxidant at 800degreesC. The results show that the reactions between LSGM and anode materials were restrained by the LDC electrolyte layer, whereas the electronic conductivity of ceria-based electrolyte was blocked by the LSGM electrolyte layer. (C)2004 The Electrochemical Society.
The COVID-19 torch (2020)

I’m still thinking about coronavirus. For the most part, I’m thinking about how lucky I am. I live in a country that has managed to avoid the outbreaks we are seeing around the world. We’ve escaped through a combination of luck and just-in-time action. We’re a very big island separated from the rest of the world by large distances, populated mostly in cities separated by large distances. It means our physical distancing can operate between populations, not just people.

From here, I watch unfolding coronavirus events around the world, without really understanding the experience you are all going through. However, COVID-19 looks like one of those hackers hired by a tech company to …
Green infrared-pumped upconversion lasers (1987)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. LENTH, R. M. MACFARLANE, and A. J. SILVERSMITH, "Green infrared-pumped upconversion lasers," Optics News 13(12), 26-27 (1987) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme (2020)

Neprilysin (NEP) and angiotensin-converting enzyme (ACE) are two key zinc-dependent metallopeptidases in the natriuretic peptide and kinin systems and renin-angiotensin-aldosterone system, respectively. They play an important role in blood pressure regulation and reducing the risk of heart failure. Vasopeptidase inhibitors omapatrilat and sampatrilat possess dual activity against these enzymes by blocking the ACE-dependent conversion of angiotensin I to the potent vasoconstrictor angiotensin II while simultaneously halting the NEP-dependent degradation of vasodilator atrial natriuretic peptide. Here, we report crystal structures of omapatrilat, sampatrilat, and sampatrilat-ASP (a sampatrilat analogue) in complex with NEP at 1.75, 2.65, and 2.6 Å, respectively. A detailed analysis of these structures and the corresponding structures of ACE with these inhibitors has provided the molecular basis of dual inhibitor recognition involving the catalytic site in both enzymes. This new information will be very useful in the design of safer and more selective vasopeptidase inhibitors of NEP and ACE for effective treatment in hypertension and heart failure.
ChipLock (2005)

The increasing need for security has caused system designers to consider placing some security support directly at the hardware level. In fact, this is starting to emerge as an important consideration in processor design, because the performance overhead of supporting security in hardware is usually significantly lower than a complete software solution. In this paper, we investigate integrating some security support into hardware. We show that security support can be added at some acceptable cost in area and performance. We propose a processor extension called ChipLock. It provides hardware security support for a mostly untrusted operating system to ensure the integrity and confidentiality of all computational results. ChipLock's modular design can be easily integrated into existing hardware platforms with only slight modification to the operating system. ChipLock includes a built-in hardware Key Manager that supports symmetric key assignment, and a read-only-memory, TrustROM, that executes secure hardware routines. The software required is a small trusted portion of the operating system called Trust-Code. We modeled ChipLock's architecture on a full system simulator and showed that, for SPEC2000 benchmarks, it adds about an average of 20% to the execution time, primarily from cryptographic and verification latencies. In addition, layout studies show an area cost of about 8 mm 2 in 180 nm technology. This translates to an area overhead of 5% ~ 15% depending on the processor type.
Design technology co-optimization of 3D-monolithic standard cells and SRAM exploiting dynamic back-bias for ultra-low-voltage operation (2017)

We have fabricated 3D-monolithic transistors on two tiers. We experimentally evidence the asymmetric double-gate (DG) behavior of a top-tier transistor, resulting in a better ON-state current (Ion) / OFF-state current (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> ) tradeoff than in single-gate (SG) mode. Moreover, a 3D-shared contact between a top and bottom electrode is experimentally demonstrated; paving the way for a local back gate, possibly connected with the top gate by a 3D-shared contact. Assuming such a construct, we have performed extensive layout and spice simulations of standard cells and SRAMs. We evidence that the back-gate overlap on the source and drain must be minimized to mitigate the parasitic capacitances. The best layout configurations of a loaded 1-finger inverter yields a 24% frequency gain at a given static power and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> = 0.6V supply voltage, compared to SG, or to a static power divided by 5, compared to SG under Forward Body Bias (FBB). These performance boosts may be obtained without any area penalty and assuming a 20nm-thin BOX. Similarly, a 29% improvement of the read and write currents of 6T SRAMs is contemplated at V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> = 0.8V. Such new functionality provided by 3D-monolithic even enables making 4T SRAMs that are fully functional at V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> = 0.8V by improving their retention and, in turn, the maximum number of bitcells per column from 50 (SG) to 300 with a dynamic back-bias.
Romiplostim for the treatment of chronic immune or idiopathic thrombocytopenic purpura: a single technology appraisal (2009)

This paper presents a summary of the evidence review group (ERG) report into the clinical and cost-effectiveness of romiplostim for the treatment of adults with chronic immune or idiopathic thrombocytopenic purpura (ITP) based upon a review of the manufacturer’s submission to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal (STA) process. The submission’s evidence came from two relatively high-quality randomised controlled trials (RCTs). The ERG found no evidence that any important data were missed or that data extraction was inaccurate. In both RCTs more patients in the romiplostim than in the placebo group achieved a durable platelet response [non-splenectomised patients: romiplostim 25/41 (61%), placebo 1/21 (5%), odds ratio (OR) 24.45, 95% confidence interval (CI) 3.34 to 179.18; splenectomised patients: romiplostim 16/42 (38%), placebo 0/21 (0%), OR 8.5 (95% CI 1.15 to 372)] and an overall platelet response [non-splenectomised patients: romiplostim 36/41 (88%), placebo 3/21 (14%), OR 34.74, 95% CI 7.77 to 155.38; splenectomised patients: romiplostim 33/42 (79%), placebo 0/21 (0%), OR 16.6 (95% CI 2.37 to 706]. The difference in mean period with a platelet response was 13.9 weeks (95% CI 10.5 to 17.4) in favour of romiplostim in the RCT of non-splectomised patients and 12.1 weeks (95% CI 8.7 to 15.6) in favour of romiplostim in the RCT of splectomised patients. The manufacturer’s economic model evaluated the cost-effectiveness of romiplostim compared with standard care. The ERG had concerns about the way the decision problem was addressed in the economic model and about the non-adjustment of findings for confounding factors. In non-splenectomised patients, using romiplostim as a first option treatment, the base-case incremental cost-effectiveness ratio (ICER) was £14,840 per quality-adjusted life-year (QALY). In splenectomised patients the ICER was £14,655 per QALY. Additional sensitivity analyses performed by the ERG identified two issues of importance: whether individuals entered the model on watch and rescue or on active therapy in the comparator arm (ICER £21,674 per QALY for non-splenectomised patients, £29,771 per QALY for splenectomised patients); whether it was assumed that any unused medicine would be wasted. Combining all of the separate sensitivity analyses, and assuming that watch and rescue was not the first-line treatment, increased the ICERs further (non-splenectomised £37,290 per QALY; splenectomised £131,017 per QALY). In conclusion, the manufacturer’s submission and additional work conducted by the ERG suggest that romiplostim has short-term efficacy for the treatment of ITP, but there is no robust evidence on long-term effectiveness or cost-effectiveness of romiplostim compared with relevant comparators.