gebhart/patrepeval huggingface dataset:
Verifiable Proof of Health using Public Key Cryptography (2020)

In the current pandemic, testing continues to be the most important tool for monitoring and curbing the disease spread and early identification of the disease to perform health-related interventions like quarantine, contact tracing and etc. Therefore, the ability to verify the testing status is pertinent as public places prepare to safely open. Recent advances in cryptographic tools have made it possible to build a secure and resilient digital-id system. In this work, we propose to build an end to end COVID-19 results verification protocol that takes privacy, computation, and other practical concerns into account for designing an inter-operable layer of testing results verification system that could potentially enable less stringent and more selective lockdowns. We also discuss various concerns encompassing the security, privacy, ethics and equity aspect of the proposed system.
Structure-Based Design, Synthesis, and Study of Potent Inhibitors of β-Ketoacyl-acyl Carrier Protein Synthase III as Potential Antimicrobial Agents (2005)

Fatty acid biosynthesis is essential for bacterial survival. Components of this biosynthetic pathway have been identified as attractive targets for the development of new antibacterial agents. FabH, beta-ketoacyl-ACP synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative bacteria. Small molecules that inhibit FabH enzymatic activity have the potential to be candidates within a novel class of selective, nontoxic, broad-spectrum antibacterials. Using crystallographic structural information on these highly conserved active sites and structure based drug design principles, a benzoylaminobenzoic acid series of compounds was developed as potent inhibitors of FabH. This inhibitor class demonstrates strong antibacterial activity against Gram-positive and selected Gram-negative organisms.
Efficient synthesis of polymeric g-C3N4 layered materials as novel efficient visible light driven photocatalysts (2011)

In order to develop efficient visible light driven photocatalysts for environmental applications, novel polymeric g-C3N4 layered materials with high surface areas are synthesized efficiently from an oxygen-containing precursor by directly treating urea in air between 450 and 600 °C, without the assistance of a template for the first time. The as-prepared g-C3N4 materials with strong visible light absorption have a band gap around 2.7 eV. The crystallinity and specific surface areas of g-C3N4 increases simultaneously when the heating temperatures increases. The g-C3N4 materials are demonstrated to exhibit much higher visible light photocatalytic activity than that of C-doped TiO2 and g-C3N4 prepared from dicyanamide for the degradation of aqueous RhB. The large surface areas, layered structure and band structure in all contributed to the efficient visible light photocatalytic activity. The efficient synthesis method for g-C3N4 combined with efficient photocatalytic activity is of significant interest for environmental pollutants degradation and solar energy conversion in large scale applications.
Porcine circovirus (PCV) removal by Q sepharose fast flow chromatography (2013)

The recently discovered contamination of oral rotavirus vaccines led to exposure of millions of infants to porcine circovirus (PCV). PCV was not detected by conventional virus screening tests. Regulatory agencies expect exclusion of adventitious viruses from biological products. Therefore, methods for inactivation/removal of viruses have to be implemented as an additional safety barrier whenever feasible. However, inactivation or removal of PCV is difficult. PCV is highly resistant to widely used physicochemical inactivation procedures. Circoviruses such as PCV are the smallest viruses known and are not expected to be effectively removed by currently-used virus filters due to the small size of the circovirus particles. Anion exchange chromatography such as Q Sepharose(®) Fast Flow (QSFF) has been shown to effectively remove a range of viruses including parvoviruses. In this study, we investigated PCV1 removal by virus filtration and by QSFF chromatography. As expected, PCV1 could not be effectively removed by virus filtration. However, PCV1 could be effectively removed by QSFF as used during the purification of monoclonal antibodies (mAbs) and a log10 reduction value (LRV) of 4.12 was obtained.
Transition State Analogs as Ligands for Affinity Purification of Juvenile Hormone Esterase (1986)

Insect juvenile hormones are metabolized in numerous species of caterpillars by low abundance, highly specific esterases. Because of their role in regulating and possibly disrupting juvenile hormone titer and thus insect metamorphosis, they are of interest to developmental biologists as well as scientists interested in selective insect control. However, the enzymes have defied attempts to purify and characterize them. Juvenile hormone esterase activity can be inhibited by a variety of 3-substituted 1,1,1-trifluoropropanone sulfides. These apparent transition state analogs were used as ligands and eluting agents to purify juvenile hormone esterase from four insect species from 500-fold to over 1000-fold in high yield. After elution from the affinity column, the enzymes were radiolabeled with paraoxon and analyzed by electrophoresis, and the results demonstrate a high degree of purity. Transition state analogs may be useful for the affinity purification of other enzymes.
Design and Implementation of a Global Self-tuning Architecture. (2005)

Abstract. Self-tuning is a feature that enables the automation of DBMS functions. The main goal is to keep a good performance while minimizing the DBA interaction with the system. This work proposes an architecture for DBMS automatic tuning. We consider here tuning as a global issue, given that changes of a single parameter can affect the performance of other operations. Besides describing the architecture details, we discuss its integration within PostgreSQL in a implementation based on software agents. This way we provide a more flexible approach to include automatic tuning features in a DBMS. Resumo. A auto-sintonia é uma característica que automatiza as operações de um SGBD visando manter um bom desempenho enquanto a interação do DBA com o sistema é reduzida. Este trabalho propõe uma arquitetura para sintonia automática de um SGBD. A tarefa de sintonia é tratada aqui como um problema global, dado que alterações de um parâmetro podem ter reflexos no desempenho de outras operações. Além da descrição dos detalhes da arquitetura, discutimos também sua integração ao PostgreSQL em uma implementação baseada em agentes de software. Dessa forma temos uma abordagem mais flexível para a inclusão de atividades de sintonia automática em um SGBD. 1.
Design and realization of a 2.4 Gbps - 3.2 Gbps clock and data recovery circuit using deep-submicron digital CMOS technology (2004)

This paper presents the design, verification, system integration and the physical realization of a high-speed monolithic phase-locked loop (PLL) based clock and data recovery (CDR) circuit. The architecture of the CDR has been realized as a two-loop structure consisting of coarse and fine loops, each of which is capable of processing the incoming low-speed reference clock and high-speed random data. Important features of this CDR include small area, single 1.2 V power supply, low power consumption, capability to operate at very high data rates, and the ability to handle between 2.4 Gbps and 3.2 Gbps data rate. The CDR architecture was realized using a conventional 0.13 /spl mu/m digital CMOS technology, which ensures a lower overall cost and better portability for the design. The circuit is capable of operating at sampling frequencies of up to 3.2 GHz, and still can achieve robust phase alignment. The overall power consumption is estimated as 18.6 mW at a 3.2 GHz sampling rate. The overall silicon area of the CDR is approximately 0.3 mm/sup 2/ including its internal loop filter capacitors.
Modeling carbon contamination of extreme ultraviolet (EUV) optics (2004)

A mathematical model is used to describe the processes that contribute to the deposition of a carbon film on EUV multilayer optics when the optic is exposed to EUV radiation in the presence of residual hydrocarbon gases. The key physical and chemical processes taken into account within the model include the transport of residual hydrocarbons to the irradiated area, molecular diffusion across the optic surface, and the subsequent dissociation or "cracking" of the hydrocarbon by both direct EUV ionization and secondary electron excitation. The dissociated hydrocarbons are reactive and form a carbonaceous film that reduces the reflectivity of the optic and the overall throughput of the EUV lithographic system. The model, which provides estimates of hydrocarbon film growth under various conditions of hydrocarbon partial pressures and EUV power, is validated by predicting the carbon thickness associated with a series of EUV exposures performed in the laboratory. The model is then used to evaluate the effects of hydrocarbon partial pressure, EUV power, hydrocarbon mass, and temperature on the growth of the carbonaceous contaminate layer.
Synthesis and Characterization of Vanadyl Phosphite, VIVOHPIIIO3.cntdot.1.5H2O (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Characterization of Vanadyl Phosphite, VIVOHPIIIO3.cntdot.1.5H2OV. V. Guliants, J. B. Benziger, and S. SundaresanCite this: Chem. Mater. 1995, 7, 8, 1485–1492Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/cm00056a013https://doi.org/10.1021/cm00056a013research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Cytoplasmic Substrate Permeation Pathway of Serotonin Transporter (2006)

Serotonin transporter (SERT) catalyzes reuptake of the neurotransmitter serotonin (5-HT) and is a target for antidepressant drugs and psychostimulants. It is a member of a large family of neurotransmitter and amino acid transporters. A recent study using site-directed cysteine modification identified a helical region of the transporter with high accessibility to the cytoplasm. Subsequently, the high resolution structure of LeuT, a prokaryotic homologue, showed that the residues corresponding to this helical region are part of the fifth transmembrane domain. The accessibility of these positions is now shown to depend on conformational changes corresponding to interconversion of SERT between two forms that face the extracellular medium and the cytoplasm, respectively. Binding of the extracellular inhibitor cocaine decreased accessibility at these positions, whereas 5-HT, the transported substrate, increased it. The effect of 5-HT required the simultaneous presence of Na+ and Cl-, which are transported into the cell together (symported) with 5-HT. In light of the LeuT structure, these results begin to define the pathway through which 5-HT diffuses between its binding site and the cytoplasm. They also confirm a prediction of the alternating access model for transport, namely, that all symported substrates must bind together before translocation.
Novel Phlebovirus with Zoonotic Potential Isolated from Ticks, Australia (2014)

Recently discovered tick-borne phleboviruses have been associated with severe disease and death among persons in Asia and the United States. We report the discovery of a novel tick phlebovirus in Tasmania State, Australia, that is closely related to those zoonotic viruses found in Asia and North America.
Isolated Systolic Hypertension Is Characterized by Increased Aortic Stiffness and Endothelial Dysfunction (2007)

Isolated systolic hypertension is associated with increased cardiovascular risk. It is thought to result from large artery stiffening, which is determined by structural components within the vasculature but also by functional factors including NO and endothelin-1. We hypothesized that endothelial dysfunction would account for increased arterial stiffness in patients with isolated systolic hypertension. The aim of this study was to investigate the relationship between endothelial function and arterial stiffness in these patients along with control subjects. We studied 113 subjects: 35 patients with isolated systolic hypertension (mean age+/-SD: 68+/-6 years), 30 age-matched control subjects (65+/-5 years), and 48 young control subjects (37+/-9 years). Aortic pulse wave velocity (PWV) was derived by sequential carotid/femoral waveform recordings. Conduit artery endothelial function was determined by flow-mediated dilatation. Aortic PWV was higher (9.65+/-2.56 m/s versus 8.26+/-0.85 m/s; P=0.009), and flow-mediated dilatation was lower (2.67+/-1.64% versus 4.79+/-3.1%; P=0.03) in patients with isolated systolic hypertension compared with age-matched control subjects. Similarly, aortic PWV was also higher, and flow-mediated dilatation lower, in older versus young control subjects (8.26+/-0.85 m/s versus 7.09+/-1.01 m/s and 4.79+/-3.1% versus 6.94+/-2.7%; P=0.004 for both). Overall, aortic PWV correlated inversely with flow-mediated dilatation (r=-0.3; P=0.001), which remained significant after adjustment for confounding factors (P=0.01). Patients with isolated systolic hypertension have higher aortic PWV and decreased endothelial function compared with age-matched control subjects. Our results suggest that endothelial function contributes significantly to increased arterial stiffness in patients with isolated systolic hypertension and with age.
High efficiency automotive power supply with hysteretic current mode controller (2002)

A switched mode power supply for an automotive power control module with a novel hysteretic current mode control (HCMC) controller is presented. The HCMC operation principle is described and a method of reducing switching frequency variation is analyzed. Experimental results and critical waveforms of the power switching regulator are shown. Several monitoring and indication functions are designed into the controller to interface with the rest of the system. The controller includes a linear regulator to provide power for memory registers while the system is in the "key-off" state.
Applied physical pharmacy (2003)

This book is designed as the core textbook for the required physical pharmacy or pharmaceutics course within the pharmacy school curriculum. With a focus on examples from pharmacy practice, this book presents the chemical and physical chemical principles fundamental to the development of medication dosage forms. Numerous case studies present relevant examples of physical chemical principles in current pharmacy practice.
Design and implementation of automatic defensive websites tamper-resistant based on OpenStack cloud system (2015)

With the popularity of Internet applications, security issues of Web become increasingly prominent. The tampering contents and embedding Trojan in public Internet website will seriously affect the public image of the government and enterprises, and result in significant economic losses and adverse social impact. To solve the above problems, we researched and developed a Web tamper-resistant system that have the characteristics of fast response, accurate judgment and flexible deploy. Cloud storage platform could provide redundant data object storage with the advantages of high durability, completely symmetrical system architecture, unlimited scalability and no single point of failure. To improve the robustness and security of tamper-proof system, we built a Cloud storage environment based on the OpenStack open source Cloud computing platform to design and implement a website anti-tamper system in Cloud environment. The Implementation of the system will help to maintain the website environmental security of the public Internet to ensure the protection of the website information and critical network information systems.
Serum reg protein level is not related to the beta cell destruction/regeneration process during early phases of diabetogenesis in type I diabetes (1999)

We conclude that serum reg protein level cannot be used as a marker for the progression of the diabetogenic process in type I diabetes.
Understand the basics of steam injection heating (1997)

Precise temperature control, reduced energy consumption, and lower maintenance costs are the key benefits of direct-contact steam injection is often overlooked or not used to its full advantage by chemical engineers because they are unaware of its potential in chemical applications. This article offers guidelines for the use of steam injection heating. It explains what steam injection heating is, describes the types of equipment used, outlines several common applications, and summarizes the information required for selecting and sizing a steam injection heater.
Syntheses and properties of core-substituted naphthalene bisimides with aryl ethynyl or cyano groups (2007)

This paper reports the synthesis, the absorption and the emission spectra and the electrochemical and spectroelectrochemical properties of new naphthalene bisimides substituted in positions 2 and 6 of the napthyl core by cyano, pyrrolidino, 4-phenylethynyl, 4-ethynyl-N,N-dihexylaniline or 4-cyanophenyl groups. The synthesis of these five new compounds shares the common precursor: 2,6-dibromonaphthalene tetracarboxylic dianhydride. We show that the aryl ethynyl substituent red-shifts the absorbance and enhances the fluorescence quantum yield of the naphthalene bisimide, making these new compounds potential useful dyes. The cyano groups directly connected to the naphthyl core significantly decrease the two first reduction potentials of the molecule. The large electron affinity and the stability of the radical anion of the latter compound make it ideally suited to transport electrons or to act as an electron acceptor.
Culture and community in online courses: A grid and group explanation (2010)

Scope and Method of Study: Using Mary Douglas' (1982) Grid and Group Typology, the purpose of this case study was to explain the distinctive patterns of student engagement, communication and community in the culture of four online courses. The participants were four online instructors and four of their students who completed online courses at Liberal Arts University in the summer of 2009. Interviews, observations and document analysis were used in both physical and virtual environments.
Chemical Neutralization to Control Denting in Nuclear Steam Generators (1983)

Laboratory testing at Combustion Engineering has indicated promise in controlling simulated steam generator tube denting through chemical neutralization. Testing was limited to on-line treatment, and two neutralizers have been evaluated: (i) calcium hydroxide, and (ii) boric acid. On-line treatment with calcium hydroxide successfully halted active denting whenever the bulk calcium concentration (in ppm) equaled or exceeded the bulk chloride concentration (in ppm). Calcium hydroxide also was effective as an alternative to ammonia as a pH controlling agent in two tests conducted without ingress of chloride. On-line treatment with boric acid consisted of a four-day soak at simulated low (approximately 30 percent) power with 50 ppm B followed by one month full-power operation with 10 ppm B. This treatment also halted denting. Nondestructive and destructive examination of test boilers gave no indication of adverse side effects associated with either neutralizer.
Porous Organic Cage Thin Films and Molecular‐Sieving Membranes (2016)

Porous organic cage molecules are fabricated into thin films and molecular-sieving membranes. Cage molecules are solution cast on various substrates to form amorphous thin films, with the structures tuned by tailoring the cage chemistry and processing conditions. For the first time, uniform and pinhole-free microporous cage thin films are formed and demonstrated as molecular-sieving membranes for selective gas separation.
Morphology of the proximal femur differs widely with age and sex: Relevance to design and selection of femoral prostheses (2012)

The ability of uncemented femoral stems to osseointegrate properly depends largely on their fit in the proximal femur. We evaluated the topography of the proximal femur and determined differences based on age and sex. Retrospectively, anteroposterior radiographs from 312 (168 male, 144 female) pre-operative total hip arthroplasty (THA) patients (age of 21-85 years) were collected. Radiographic measurements were taken at 10 mm intervals along the length of the femur. Variables including canal flare index (CFI) and cortical index (CI) were calculated. Data were binned into three age groups and separated by sex for comparison. Measurements showed that CFI decreased with age for both sexes; however, females demonstrated a greater decrease. Decrease in flare occurred primarily on the lateral side. CI also decreased with age, the most pronounced drop occurring in older females. A clear difference exists between male and female proximal femoral geometry. This decrease is most likely attributed to the loss of cortical bone. The medial component likely demonstrates less loss of flare due to strong compressive forces that are transmitted through this portion of the femur. These results demonstrate the necessity of considering age and sex when selecting a proper prosthesis.