gebhart/patrepeval huggingface dataset:
Basic performance of an organic dye-doped polymer optical fiber amplifier (1995)

A polymer optical fiber amplifier (POFA) of the graded-index (GI) type, with gain in the visible region, was successfully prepared for the first time, to our knowledge, with the interfacial-gel polymerization technique. An input signal of 0.85Wat 591 nm was amplified to 420W(27-dB gain) by injection of 690W of pump power at 532 nm into a GI POFA with a 0.5-m length. The efficiency of conversion of pump energy to signal amplification was more than 60%.
Compact MEMS-based adaptive optics: optical coherence tomography for clinical use (2008)

We describe a compact MEMS-based adaptive optics (AO) optical coherence tomography (OCT) system with improved AO performance and ease of clinical use. A typical AO system consists of a Shack-Hartmann wavefront sensor and a deformable mirror that measures and corrects the ocular and system aberrations. Because of limitations on current deformable mirror technologies, the amount of real-time ocular-aberration compensation is restricted and small in previous AO-OCT instruments. In this instrument, we incorporate an optical apparatus to correct the spectacle aberrations of the patients such as myopia, hyperopia and astigmatism. This eliminates the tedious process of using trial lenses in clinical imaging. Different amount of spectacle aberration compensation was achieved by motorized stages and automated with the AO computer for ease of clinical use. In addition, the compact AO-OCT was optimized to have minimum system aberrations to reduce AO registration errors and improve AO performance.
Generation of quasi-monoenergetic ion beams using short and intense laser pulses (2007)

Laser-accelerated ion sources have exceptional properties and could stimulate development of compact ion accelerators. For many applications beam control is an essential requirement. A new and interesting technique to control proton beam characteristics has been recently developed. It consists in using an ultrafast laser-triggered micro-lens, which provides simultaneous energy selection and focusing of the incoming ion beam and is tunable. Particle-in-cell simulations coupled with particle tracing are used to model the focusing and energy selection mechanisms, and to study the symmetry of the expanding plasma inside the micro-lens. The model developed is able to reproduce and explain the experimental results obtained at the Laboratoire pour l'Utilisation des Lasers Intenses in France.
Key challenges for the piezo technology with applications to low form factor thermal solutions (2006)

The thermal performance of piezoelectric actuators for cooling in low form factor applications is presented. A significant reduction in thermal resistance is achievable when compared to the baseline natural convection. Comparisons with fans and blowers of similar size result in comparable performance but at greatly reduced power consumption
Characterization of the Gene Encoding a 26-Kilodalton Protein (OMP26) from Nontypeable Haemophilus influenzae and Immune Responses to the Recombinant Protein (1999)

A 26-kDa protein (OMP26) isolated and purified from nontypeableHaemophilus influenzae (NTHI) strain 289 has been shown to enhance clearance of infection following pulmonary challenge with NTHI in rats. DNA sequence analysis revealed that it was 99% identical to a gene encoding a cell envelope protein of the H. influenzaeRd strain (TIGR accession no. HI0916). The deduced amino acid sequence revealed a hydrophilic polypeptide rich in basic amino acids. Restriction fragment length polymorphism analysis suggested that the OMP26 gene was relatively conserved among isolates of NTHI. Analysis of the deduced amino acid sequence of the OMP26 gene from 20 different isolates showed that similarity with NTHI-289 ranged from 96.5% (1 isolate) to 99.5% (14 isolates). Two recombinant forms of OMP26, a full length 28-kDa protein (equivalent to preprotein) and a 26-kDa protein lacking a 23-amino-acid leader peptide (equivalent to processed protein), were assessed in immunization studies for the ability to induce an immune response that would be as effective as the native protein in enhancing the clearance of NTHI following pulmonary challenge in rats. Immunization with the recombinant protein that included the leader peptide was more effective in enhancing pulmonary clearance, and it induced a better cell-mediated response and higher titers of systemic and mucosal antibody. This study has characterized a 26-kDa protein from NTHI that shows significant potential as a vaccine candidate.
Multiscale edge-guided wavelet snake model for delineation of pulmonary nodules in chest radiographs (2003)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Development of an assay to measure in vivo cytokine production in the mouse (1999)

The short in vivo lifespan of many cytokines can make measurement of in vivo cytokine production difficult. A method was developed to measure in vivo IL-4 and IFN-gamma production that eliminates this problem. Mice are injected with a biotin-labeled neutralizing IgG anti-IL-4 or anti-IFN-gamma mAb and bled 2-24 h later. Secreted cytokine is captured by the biotin-labeled mAb to produce a complex that has a relatively long in vivo half-life and consequently accumulates in serum. Serum concentrations of the complex are determined by ELISA, using wells coated with an antibody to a second epitope on the same cytokine to capture the complex. This technique is specific and increases sensitivity of detection of secreted IL-4 at least 1000-fold. The amount of cytokine measured is directly proportional to the amount produced and relatively independent of the site of cytokine production. Furthermore, because mice are injected with small quantities of biotin-labeled anti-cytokine mAb, which sample, rather than neutralize, all secreted cytokines, cytokine-dependent responses are not inhibited. The in vivo half-lives of the cytokine-anti-cytokine mAb complexes are sufficiently short to allow cytokine production to be measured every 2-3 days in the same mice. Thus, use of this assay provides a practical and relatively simple and inexpensive way to measure ongoing in vivo cytokine production. Furthermore, the techniques that have been developed to measure in vivo production of IL-4 and IFN-gamma can be applied to in vivo measurement of other molecules that have a short in vivo lifespan, including other cytokines.
First Borehole to Surface Electromagnetic Survey in KSA: Reservoir Mapping and Monitoring at a New Scale (2011)

Abstract The first Borehole to Surface Electromagnetic (BSEM) pilot field survey in the Kingdom of Saudi Arabia (KSA) was successfully executed to identify oil and water bearing reservoir layers in a carbonate oilfield water injection zone. Maximizing recovery factor by means of detailed mapping of hydrocarbon accumulations in the reservoirs is a key requirement for oil producing companies. This mapping is done routinely by accurate measurements of fluid distribution at the wells’ locations, but a knowledge gap exists in the inter-well volumes, where typically only density-based measurements are available (seismic and gravity). Such technologies are not always effective to discriminate and quantify the fluids in the porous space (especially when difference in fluid densities is small, such as oil and water). On the contrary, when high electrical resistivity contrasts exist between hydrocarbons and water, electromagnetic (EM) based technologies have the potential to map the distribution of the fluids and monitor their movement during the life of the field, hundreds of meters or kilometers away from the wellbores. The objective of a BSEM survey is to obtain fluid sensitive resistivity and induced polarization maps. These are based on an acquisition grid at the surface, a few kilometers around the EM transmitting well, which reveal oil and water bearing zones in the investigated reservoir layers. In this pilot field test, BSEM showed the potential to map water-front movements in an area of about 4km from the single well surveyed, evaluate the sweep efficiency, identify bypassed/ lagged oil zones, and eventually monitor the fluid displacements, if surveys are repeated over time. The data quality of the recorded signals is highly satisfactory. Fluid distribution maps obtained with BSEM are coherent with production data measured at the wells’ locations, filling the knowledge gap of the interwells area. Three key R&D objectives for this BSEM pilot are achieved. Firstly, the capability to record at the surface EM signals generated in the reservoir, secondly, the capability of BSEM to discriminate between oil and water saturated reservoir zones, and finally obtain resistivity maps and a fluid distribution estimate plausible and coherent with the information obtained from well logs, crosswell EM, production data and reservoir models. In addition to reservoir monitoring, BSEM can be very useful in non-diagnosed areas like exploration fields for hydrocarbon exploitations.
Design and fabrication of a 128-channel array of quantum memories in hybrid photonic circuits (2020)

We show the design, fabrication, and integration of a 128-channel aluminum nitride photonic chip with tunable diamond quantum micro-chiplets containing silicon vacancy and germanium vacancy color centers, enabling a chip-integrated architecture towards multiplexed photon-mediated entanglement.
Narrow-band, fixed-tuned, and tunable bandpass filters with zig-zag hairpin-comb resonators (2003)

"Hairpin-comb" filters have been previously shown to have special properties that are advantageous for the design of compact, narrow-band, and bandpass microstrip filters. Herein, a new "zig-zag" form of hairpin-comb filter is introduced, which is shown to have additional important advantages for designing compact narrow-band filters. Examples with computed responses and the measured results from high-temperature superconductor trial designs are presented. The considerable flexibility available in the design of bandpass filters of this sort is shown to be helpful in the design of tunable bandpass filters having nearly constant bandwidth and passband shape as they are tuned. Measured results for tuning over nearly an octave range are presented.
Development of microcolumnar LaBr 3 :Ce scintillator (2009)

While a wide variety of new scintillators are now available, new cerium-doped lanthanide halide scintillators have shown a strong potential to move beyond their familiar role in conventional gamma ray spectroscopy, toward fulfilling the needs of highly demanding applications such as radioisotope identification at room temperature, homeland security, and quantitative molecular imaging for medical diagnostics, staging and research. Despite their extraordinary advantages, however, issues related to reliable, large volume manufacturing of these high light yield materials in a rapid and economic manner have not been resolved or purposefully addressed. Also, if microcolumnar films of this material could be fabricated, it would find widespread use in a multitude of high-speed imaging/nuclear medicine applications. Here we report on synthesizing LaBr3:Ce scintillators using a thermal evaporation technique, which permits the fabrication of high spatial resolution microcolumnar films and holds a potential to synthesize large volumes of high quality material in a time efficient and cost effective manner. Performance evaluation of the fabricated films and their application for SPECT imaging are also discussed.
A Resource-Efficient Embedded Iris Recognition System Using Fully\n Convolutional Networks (2019)

Applications of Fully Convolutional Networks (FCN) in iris segmentation have\nshown promising advances. For mobile and embedded systems, a significant\nchallenge is that the proposed FCN architectures are extremely computationally\ndemanding. In this article, we propose a resource-efficient, end-to-end iris\nrecognition flow, which consists of FCN-based segmentation, contour fitting,\nfollowed by Daugman normalization and encoding. To attain accurate and\nefficient FCN models, we propose a three-step SW/HW co-design methodology\nconsisting of FCN architectural exploration, precision quantization, and\nhardware acceleration. In our exploration, we propose multiple FCN models, and\nin comparison to previous works, our best-performing model requires 50X less\nFLOPs per inference while achieving a new state-of-the-art segmentation\naccuracy. Next, we select the most efficient set of models and further reduce\ntheir computational complexity through weights and activations quantization\nusing 8-bit dynamic fixed-point (DFP) format. Each model is then incorporated\ninto an end-to-end flow for true recognition performance evaluation. A few of\nour end-to-end pipelines outperform the previous state-of-the-art on two\ndatasets evaluated. Finally, we propose a novel DFP accelerator and fully\ndemonstrate the SW/HW co-design realization of our flow on an embedded FPGA\nplatform. In comparison with the embedded CPU, our hardware acceleration\nachieves up to 8.3X speedup for the overall pipeline while using less than 15%\nof the available FPGA resources. We also provide comparisons between the FPGA\nsystem and an embedded GPU showing different benefits and drawbacks for the two\nplatforms.\n
Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes (2006)

To better understand Neisseria meningitidis genomes and virulence, microarray comparative genome hybridization (mCGH) data were collected from one Neisseria cinerea, two Neisseria lactamica, two Neisseria gonorrhoeae and 48 Neisseria meningitidis isolates. For N. meningitidis, these isolates are from diverse clonal complexes, invasive and carriage strains, and all major serogroups. The microarray platform represented N. meningitidis strains MC58, Z2491 and FAM18, and N. gonorrhoeae FA1090. By comparing hybridization data to genome sequences, the core N. meningitidis genome and insertions/deletions (e.g. capsule locus, type I secretion system) related to pathogenicity were identified, including further characterization of the capsule locus, bioinformatics analysis of a type I secretion system, and identification of some metabolic pathways associated with intracellular survival in pathogens. Hybridization data clustered meningococcal isolates from similar clonal complexes that were distinguished by the differential presence of six distinct islands of horizontal transfer. Several of these islands contained prophage or other mobile elements, including a novel prophage and a transposon carrying portions of a type I secretion system. Acquisition of some genetic islands appears to have occurred in multiple lineages, including transfer between N. lactamica and N. meningitidis. However, island acquisition occurs infrequently, such that the genomic-level relationship is not obscured within clonal complexes. The N. meningitidis genome is characterized by the horizontal acquisition of multiple genetic islands; the study of these islands reveals important sets of genes varying between isolates and likely to be related to pathogenicity.
Neutron scattering studies of superconducting MgB<sub>2</sub>tapes (2003)

The capability of manufacturing long superconducting MgB2 wires with already remarkable critical currents makes this material a very promising candidate for future applications. Tapes are prepared by the powder-in-tube technique. After the cold working procedure typically carried out by wire drawing and cold rolling, it has been found that a final sintering step carried out in argon atmosphere is a key process for further improving the superconducting properties of the conductors. To study the effect of the deformation and heat treatment processes, we performed neutron scattering experiment. Due to the high penetration depth of neutron inside matter, it was possible to analyse the MgB2 phase still wrapped in the Ni sheath. Our studies were carried out by a full spectra refinement by the Rietveld method. In the starting superconducting powder a large Mg deficiency was observed. In the tapes we found that the large forces applied during the cold working induced a large MgB2 lattice deformation, and that it is partly relaxed during the final sintering process. An important correlation of the residual stress with the critical temperature and the pinning properties was pointed out. We also observed the appearance of detrimental secondary phases during the sintering process. In particular, the MgB2 phase reacted with the nickel sheath and MgB2Ni2.5 was formed at temperatures higher than 850 °C. These results are of basic importance for a further optimization of the transport properties at moderate fields where applications of MgB2 tapes are already envisageable.
Oxidative Chemical Vapor Deposition of Electrically Conducting Poly(3,4-ethylenedioxythiophene) Films (2006)

An oxidative chemical vapor deposition (CVD) process is presented as an alternative to conventional solution-based processing of poly(3,4-ethylenedioxythiophene) (PEDOT) thin films. This solventless technique yields PEDOT with higher conductivities and conformally coats fibers and other high area morphologies, important for enhancing efficiencies in some organic electronic devices. The CVD method eliminates corrosive poly(styrenesulfonate) that is used to disperse PEDOT in an aqueous suspension for solution-based processing. A mechanistic approach is presented that favors the deposition of the conjugated, conducting form of PEDOT. We achieved conductivities as high as 105 S/cm and demonstrated films about 100 nm thick that do not crack upon bending and are more than 84% transparent to visible light. The compatibility of oxidative CVD deposition of PEDOT is demonstrated on silicon, glass, plastic, and paper substrates.
Noise robust model adaptation using linear spline interpolation (2009)

This paper presents a novel data-driven technique for performing acoustic model adaptation to noisy environments. In the presence of additive noise, the relationship between log mel spectra of speech, noise and noisy speech is nonlinear. Traditional methods linearize this relationship using the mode of the nonlinearity or use some other approximation. The approach presented in this paper models this nonlinear relationship using linear spline regression. In this method, the set of spline parameters that minimizes the error between the predicted and actual noisy speech features is learned from training data, and used at runtime to adapt clean acoustic model parameters to the current noise conditions. Experiments were performed to evaluate the performance of the system on the Aurora 2 task. Results show that the proposed adaptation algorithm (word accuracy 89.22%) outperforms VTS model adaptation (word accuracy 88.38%).
Probabilistic Source Localization Based on Time-of-Arrival Measurements (2020)

This article was motivated by the need to localize a sensor (signal source) in an Internet-of-Things (IoT) network to an area with a predetermined probability (credibility). The source is assumed to transmit a short time duration (burst) signal in a homogeneous line-of-sight environment. The source's signal is known to an array of spatially separated receivers, which can measure the times of arrival of the source's signal subject to Gaussian measurement errors. The time that the signal leaves the source (i.e., the transmit time) is, however, unknown. The authors develop a method for computing the exact a posteriori probability density functions (pdfs) of the coordinates of the source's in both 2-D and 3-D spaces. The obtained a posteriori pdfs incorporate arbitrary a priori densities, which makes them very useful in many practical scenarios. Unlike existing point-estimate methods, the probabilistic method does not simultaneously solve a set of equations so there is neither a lower nor upper limit on the number of receivers. Various examples are provided to demonstrate the superiority and usefulness of the proposed method. In particular, it is shown that the joint a posteriori pdf of the target's location is not always approximately jointly Gaussian, especially when the target is in close proximity to one of the gateways, or when the gateways are located in close proximity to each other.
Investigating the use of controlled natural language as problem definition input for computer-aided design (2014)

We intend to develop a computer-aided design (CAD) system that takes design problem definitions as input and presents a set of geometries that solves the problem. For such system, we perceive using a controlled natural language (CNL) as one method within a multimodal interface to capture some of the required input. To evaluate the feasibility of using a CNL for problem definitions, we conducted a user study with 18 participants. We found that using a CNL increases the quality of problem definition statements for functional requirements compared to statements written in natural language. While a CNL limits the breadth of problem definitions, it can achieve a balance between natural expression and formal specification of problem definitions.
Down-scaling differential pairs of depleted optical thyristors (1995)

We present the results of a scaling study of monolithic differential pairs of optical thyristors. The devices are depleted thyristors, intended for high-frequency and high-sensitivity operation. According to the measurements, the optical switching energy scales with area and equals to 15 aJ/μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The smallest pair with mesas of 10×15 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> operates with 2.6 fJ of light input. Sub-femtojoule optical switching energy is expected in the near future.
Detrimental Effects of Sodium during Mouse Oocyte Cryopreservation (1998)

Cryopreservation is an established way of storing embryos, but effective methods are not available for freezing eggs. Most freezing damage is caused by high solute concentration (solution effects) and intracellular ice. Sodium salts are the major components of cryopreservation media, and the main contributor to the solution effects. The present experiments examine the effect of substituting choline for sodium as the major extracellular cation in the cryopreservation of mouse eggs. The effects of serum and various cryoprotectants were also examined. Survival, fertilization, and development were inversely related to the concentration of sodium in the freezing medium. Oocytes frozen in a choline-based medium had the highest (p < 0.001) survival and development rates. The absence of serum during thawing inhibited fertilization, whereas exposure to serum or opening the zona allowed fertilization to reach the control level. Dimethyl sulfoxide was as effective as 1,2 propanediol for obtaining high survival and fertilization rates. These results support the hypothesis that the high concentration of sodium in conventional freezing media is detrimental to cells and show that choline is a promising replacement for sodium. Reducing or eliminating sodium may allow oocytes and other cells to be frozen more efficiently.