gebhart/patrepeval huggingface dataset:
<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p> (2020)

Compared to other domains, tissue engineering and esthetics have dramatically expanded in recent years, leading to both major biomedical advances and futuristic perspectives. The two share a common approach based on biomaterials, especially polymers. This paper illustrates this with the example of polycaprolactone (PCL), a polymer synthesized in the early 1930s, and one of its most recent applications, a PCL-based collagen stimulator, a filler used in esthetics. PCL is biocompatible and biodegradable. Its specific physicochemical and mechanical properties, viscoelasticity and ease of shaping led to the production of PCL-based products with various shapes and durations dependent on its biodegradation kinetics. PCL has been safely used in the biomedical field for more than 70 years, from sutures to tissue and organ replacement by 3D printing. The PCL-based collagen stimulator is composed of PCL microspheres suspended in a carboxymethyl-cellulose gel carrier providing immediate and sustained volumizing effects when injected; the morphology, the biocompatibility of the PCL microspheres embedded with the collagen fibers produced all contribute to the creation of a unique 3D scaffold for a sustained effect. Its safety has been investigated in clinical studies and vigilance surveys. Recently published experts' recommendations on injection modalities and techniques should help further optimize treatment outcome and safety. This paper also integrates reviews and recommendations on the prevention and management of adverse events related to dermal and subdermal fillers including the PCL-based collagen stimulator. In addition, in terms of efficacy and safety, this product benefits from its daily clinical use in esthetics worldwide and continuous extensive fundamental and clinical research, both on it and the PCL polymer. Forthcoming data from further investigations will reinforce knowledge of the product and procedures in the field.
In Vivo Translation of the Triple Gene Block of Potato Virus X Requires Two Subgenomic mRNAs (1998)

The 25-kilodalton (25K), 12K, and 8K movement proteins of potato virus X are derived from overlapping open reading frames (ORFs). Using an in vivo complementation assay, we have shown that the 25K protein is expressed from a functionally monocistronic mRNA, whereas the 12K and 8K proteins are from a bicistronic mRNA. Translation of the 8K ORF is by leaky ribosome scanning through the 12K ORF.
Robot personality based on the equations of emotion defined in the 3D mental space (2002)

The authors deal with human-like head robots in order to develop new head mechanisms and functions for a humanoid robot that has the ability to communicate naturally with a human by expressing human-like emotion. When humans communicate through auditory or visual sensations, they estimate their mental state through not only the information of each sensation but also their mental model. A robot's mental model consists of a 3D mental space having a pleasantness, and activation and a certainty axes. When the robot senses the stimulus, a mental vector moves in this mental space based on the equations of emotion. We also propose a robot personality which consists of sensing personality and expression personality. Further, we assign and load various sensing personalities.
Basic Charge Clusters and Predictions of Membrane Protein Topology (2002)

The topology predictor SPLIT 4.0 (http://pref.etfos.hr) predicts the sequence location of transmembrane helices by performing an automatic selection of optimal amino acid attribute and corresponding preference functions. The best topological model is selected by choosing the highest absolute bias parameter that combines the bias in basic charge motifs and the bias in positive residues (the "positive inside rule") with the charge difference across the first transmembrane segment. Basic charge motifs, such as the BBB, BXXBB, and BBXXB motifs in alpha-helical integral membrane proteins, are significantly more frequent near cytoplasmic membrane surface than expected from the Arg/Lys (B) frequency. The predictor's accuracy is 99% for predicting 178 transmembrane helices in all membrane proteins or subunits of known 3D structure.
Type I-polarized BRAF-pulsed dendritic cells induce antigen-specific CD8+ T cells that impact BRAF-mutant murine melanoma (2015)

Existing therapies targeting the mutated BRAF oncodriver (BRAF(V600E)) successfully treat melanoma but are susceptible to resistance. This study assessed the potential of a dendritic cell-based BRAF(V600E) vaccine for the treatment of BRAF(V600E)-mutant melanoma. Type 1-polarized dendritic cells (DC1) pulsed with affinity-modified BRAF(V600E) peptide were administered to C57Bl/6 mice both before (prevention) and twice weekly after (treatment) the development of established tumor with B16 melanoma transfected to express BRAF(V600E) (B16(V600E)). The efficacy of the BRAF(V600E)-pulsed DC1 vaccine was corroborated in a novel transplantable BRAF(V600E)-mutant murine melanoma model (BRAF(V600E-/+); PTEN(-/-); CDK2NA(-/-)). Three-dimensional tumor measurements and survival were determined. Induction of BRAF(V600E)-specific CD8(+) T-cell responses after brief in-vitro sensitization was assessed by interferon-γ enzyme-linked immunosorbent assay and/or enzyme-linked immunospot. Mice receiving BRAF(V600E)-pulsed DC1 vaccines before B16(V600E) tumor challenge demonstrated increased tumor-doubling times (P<0.001) and improved survival (P=0.0186) compared with those that received ovalbumin (control)-pulsed DC1 vaccines. In mice bearing established B16(V600E) tumors (mean 32 mm(3)), BRAF-pulsed DC1 vaccines delayed tumor growth (P<0.001) and improved survival (P=0.0008), compared with untreated mice. Likewise, in mice bearing BRAF(V600E-/+); PTEN(-/-); CDK2NA(-/-) tumors, compared with controls, BRAF-DC1 vaccination recapitulated these effects by delaying tumor growth (P<0.001) and improving survival (P=0.002). Vaccination elicited specific CD8(+) T-cell recognition of BRAF(V600E)-pulsed antigen-presenting cells (P<0.05), as well as BRAF(V600E)-expressing cancer cells (P<0.001), measured by interferon-γ release in vitro. BRAF-(V600E)pulsed DC1 vaccines induce oncogene-specific CD8(+) T-cell immune responses that impact tumor growth and survival in preclinical models of BRAF(V600E)-mutant melanoma. Exploration of BRAF(V600E)-targeted vaccines, in combination with BRAF-targeted therapies and checkpoint inhibitors, is warranted.
Cooking gesture recognition using local feature and depth image (2012)

In this paper, we propose a method combining visual local features and depth image information to recognize cooking gestures. We employ the feature calculation method[2] which used extended FAST detector and a compact descriptor CHOG3D to calculate visual local features. We pack the local features by BoW in frame sequences to represent the cooking gestures. In addition, the depth images of hands gestures are extracted and integrated spatio-temporally to represent the position and trajectory information of cooking gestures. The two kinds of features are used to describe cooking gestures, and recognition is realized by employing the SVM. In our method, we determine the gesture class for each frame in cooking sequences. By analyzing the results of frames, we recognize cooking gestures in a continue frame sequences of cooking menus, and find the temporal positions of the recognized gestures.
Clinical evaluation of an ensemble‐averaging impedance cardiograph for monitoring stroke volume during spontaneous breathing (1990)

Simultaneous determination of stroke volume (SV) with an ensemble-averaging impedance cardiograph (AIGG) and the thermodilution technique (TD) was compared in 10 patients scheduled for major vascular surgery. A small, successive increase in SV was achieved by a step-wise infusion of dextran-70 and elevation of the patient's legs. The patients were allowed to breathe normally during the measurement procedures. There was no difference between the ability of AICG and TD to monitor changes in SV and the correlation coefficient for the measurement of changes in SV by the two methods was 0.88. There was no difference between the reproducibility of AICG- (4.6 ml) and TD- (9.2 ml) determined SV or between the coefficient of variation for AICG (4.8%) and TD (9.9%). The mean difference between AICG- and TD-determined SV at the different measurement points (range 1.3-4.2 ml) was well within acceptable limits. In conclusion, the ensemble-averaging impedance cardiograph described in this study was found to be reliable for monitoring changes in SV during uninterrupted, spontaneous breathing.
Conversion of analog to spiking neural networks using sparse temporal coding (2018)

The activations of an analog neural network (ANN) are usually treated as representing an analog firing rate. When mapping the ANN onto an equivalent spiking neural network (SNN), this rate-based conversion can lead to undesired increases in computation cost and memory access, if firing rates are high. This work presents an efficient temporal encoding scheme, where the analog activation of a neuron in the ANN is treated as the instantaneous firing rate given by the time-to-first-spike (TTFS) in the converted SNN. By making use of temporal information carried by a single spike, we show a new spiking network model that uses 7-10× fewer operations than the original rate-based analog model on the MNIST handwritten dataset, with an accuracy loss of <; 1%.
Kinetics of the Reaction of Formaldehyde with Ammonia at 23°C as Followed by an Ammonia Selective Electrode (1991)

The reaction at trace NH3 concentration with HCHO, under alkaline conditions, was followed using an NH3 selective electrode. The overall reaction is complex; there is a very rapid reaction, increas...
Inhibition of Platelet GPVI Protects Against Myocardial Ischemia–Reperfusion Injury (2016)

Inhibition of platelet activation by an anti-GPVI antibody, but not inhibition of platelet adhesion or aggregation by an anti-GPIb or anti-GPIIbIIIa antibody significantly reduces infarct size. The reduction of the infarct size is primarily based on an improved microperfusion after anti-GPVI antibody treatment.
<i>Eitneria tenella</i>: immunological diversity between asexual generations (1988)

In the development of a normal strain, WIS, of Eimeria tenella there are three generations of schizogony whereas in an attenuated line, WIS-F-96, derived from WIS, the second and third are absent. Chickens immunized by infection with WIS-F-96, however, were highly resistant to oral challenge with sporulated oocysts of WIS, and histological studies indicated that the immune response was directed against the sporozoites from that challenge inoculum. When challenge of the WIS-F-96-primed chickens consisted of second generation merozoites of WIS (inoculated intracaecally), immunity was less pronounced and the histological data indicated that the merozoites proceeded to develop normally in these birds. These indications of immunological diversity between the merozoites of the first and second generations of schizogony of E. tenella WIS correlated with the results of preliminary studies of the antigenic composition of these developmental stages.
The effect of particle size on the genotoxicity of gold nanoparticles (2016)

Despite the increasing biomedical applications of gold nanoparticles (AuNPs), their toxicological effects need to be thoroughly understood. In the present study, the genotoxic potential of commercially available AuNPs with varying size (5, 20, and 50 nm) were assessed using a battery of in vitro and in vivo genotoxicity assays. In the comet assay, 20 and 50 nm AuNPs did not induce obvious DNA damage in HepG2 cells at the tested concentrations, whereas 5 nm NPs induced a dose-dependent increment in DNA damage after 24-h exposure. Furthermore, 5 nm AuNPs induced cell cycle arrest in G1 phase in response to DNA damage, and promoted the production of reactive oxygen species (ROS). In the chromosomal aberration test, AuNPs exposure did not increase in the frequency of chromosomal aberrations in Chinese hamster lung (CHL) cells. In the standard in vivo micronucleus test, no obvious increase in the frequency of micronucleus formation was found in mice after 4 day exposure of AuNPs. However, when the exposure period was extended to 14 days, 5 nm AuNPs presented significant clastogenic damage, with a dose-dependent increase of micronuclei frequencies. This finding suggests that particle size plays an important role in determining the genotoxicity of AuNPs. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 710-719, 2017.
Hysteresis Modeling of Semi-Active Magnetorheological Helicopter Dampers (1999)

MR dampers in soft-inplane rotors such as hingeless and bearingless rotors have potential benefits including semi-active control of aeromechanical instabilities, such as ground and air resonance. An experimental performance characterization of hybrid elastomeric/MR dampers for the 1/6th scale Comanche wind tunnel model rotor is presented. These dampers are similar to prior fluidelastomeric Comanche wind tunnel model dampers, except that the passive fluid is replaced by an MR fluid. MR lag dampers were tested under a compressive preload with the magnetic field turned on (ON condition) and off (OFF condition). Damping was characterized for single frequency sinusoidal excitation at the lag/rev (10 Hz) frequency; that is, the lightly damped inplane rotor blade bending mode that plays a dominant role in aeromechanical instabilities. Dual frequency testing was also carried out at 10 Hz and 15 Hz corresponding to the model rotor lag/rev and 1 /rev or rotor RPM frequencies respectively. In all of these tests, the force versus displacement hysteresis cycle or energy diagram was measured for the MR dampers. Two nonlinear models are compared: (1) a stiffness plus viscoelastic-plastic model, and (2) a stiffness-viscosity-elasto-slide model. These models were developed to capture the nonlinear behavior of these dampers. The model parameters were identified by minimizing the mean squared error between the predicted and measured MR damper force time histories due to a lag/rev harmonic excitation. Model validation for both single and dual frequency data was carried out. A key conclusion is that both models accurately predict damping performance, which suggests that the underlying hysteresis model is not unique when only damping is the performance metric.
Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice (2009)

Insulin-dependent diabetes mellitus (IDDM) is characterized by the rapid development of potentially severe metabolic abnormalities resulting from insulin deficiency. The transplantation of insulin-producing cells is a promising approach for the treatment of IDDM. The transcription factor pancreatic duodenal homeobox 1 (Pdx1) plays an important role in the differentiation of pancreatic beta cells. In this study, the human Pdx1 gene was transduced and expressed in murine adipose tissue-derived stem cells (ASCs). To evaluate pancreatic repair, we used a mouse model of pancreatic damage resulting in hyperglycemia, which involves injection of mice with streptozotocin (STZ). STZ-treated mice transplanted with Pdx1-transduced ASCs (Pdx1-ASCs) showed significantly decreased blood glucose levels and increased survival, when compared with control mice. While stable expression of Pdx1 in ASCs did not induce the pancreatic phenotype in vitro in our experiment, the transplanted stem cells became engrafted in the pancreas, wherein they expressed insulin and C-peptide, which is a marker of insulin-producing cells. These results suggest that Pdx1-ASCs are stably engrafted in the pancreas, acquire a functional beta-cell phenotype, and partially restore pancreatic function in vivo. The ease and safety associated with extirpating high numbers of cells from adipose tissues support the applicability of this system to developing a new cell therapy for IDDM.
Bone Grafting and Guided Bone Regeneration for Immediate Dental Implants in Humans (1994)

This study evaluated bone regeneration and osseointegration of hydroxyapatite (HA) coated and titanium plasma sprayed (TPS) implants placed in sockets immediately after extraction in 36 adults, mean age 55.2 years (range 26 to 81 years). Twelve TPS and 10 HA-coated implants in 20 patients were grafted with demineralized freeze-dried bone allograft (DFDBA), covered with a barrier material, and the facial flap coronally positioned to attain primary closure (experimental). The remaining 11 TPS and 10 HA-coated implants were placed similarly, except that no DFDBA was used (control). Osseous structures were measured at the initial placement and 6-month re-entry surgeries. At the 6-month re-entry, all implants placed were clinically osseointegrated. Bone resorption at the most coronal socket crest was -1.53 mm for the grafted group and -1.59 mm for the control group. Crestal bone apposition of 1.39 mm was noted at the most apical socket crest (ASC) for the grafted group, whereas crestal resorption of -0.11 mm was noted in the ungrafted control group (P < 0.02). Bone fill from the base of the deepest osseous defect was 5.68 mm for the grafted group and 3.18 mm for the control group (P < 0.04). Complete resolution of osseous defects occurred at 15 of 22 sites in the grafted group and at 9 of 21 sites in the control group. Clinical exposure of the barrier material and a subsequent inflammatory response at 27 of 43 sites, requires removal of the material prior to the 6-month re-entry and was associated with significantly more bone loss at the ASC sites (P < 0.01). There was no significant difference for any of the parameters when comparing the TPS with the HA-coated implants.
Advantages of Radiochemistry in Microliter Volumes (2016)

Positron emission tomography (PET) provides quantitative 3D visualization of physiological parameters (e.g., metabolic rate, receptor density, gene expression, blood flow) in real time in the living body. By enabling measurement of differences in such characteristics between normal and diseased tissues, PET serves as vital tool for basic research as well as for clinical diagnosis and patient management. Prior to a PET scan, the patient is injected with a short-lived tracer labeled with a positron-emitting isotope. Safe preparation of the tracer is an expensive process, requiring specially trained personnel and high-cost equipment operated within hot cells. The current centralized manufacturing strategy, in which large batches are prepared and divided among many patients, enables the most commonly used tracer (i.e., [18F]FDG) to be obtained at an affordable price. However, as the diversity of tracers increases, other strategies for cost reduction will become necessary. This challenge is being addressed by the development of miniaturized radiochemistry instrumentation based on microfluidics. These compact systems have the potential to significantly reduce equipment cost and shielding while increasing diversity of tracers produced in a given facility. The most common approach uses “flow-through” microreactors, which leverage the ability to precisely control reaction conditions to improve synthesis times and yields. Several groups have also developed “batch” microreactors which offer significant additional advantages such as reduced reagent consumption, simpler purifications, and exceptionally high specific activity, by reducing operating volumes by orders of magnitude. In this chapter, we review these “batch” approaches and the advantages of using small volumes, with special emphasis on digital microfluidics, in which reactions have been performed with volumes as low as ~1 μL.
Step Detection for ZUPT-Aided Inertial Pedestrian Navigation System Using Foot-Mounted Permanent Magnet (2016)

A foot-mounted pedestrian dead reckoning system is a self-contained technique for indoor localization. An inertial pedestrian navigation system includes wearable MEMS inertial sensors, such as an accelerometer, gyroscope, or digital compass, which enable the measurement of the step length and the heading direction. Therefore, the use of zero velocity updates is necessary to minimize the inertial drift accumulation of the sensors. The aim of this paper is to develop a foot-mounted pedestrian dead reckoning system based on an inertial measurement unit and a permanent magnet. Our approach enables the stance phase and the step duration detection based on the measurements of the permanent magnet field during each gait cycle. The proposed system involves several parts: inertial state estimation, stance phase detection, altitude measurement, and error state Kalman Filter with zero velocity update and altitude measurement update. Real indoor experiments demonstrate that the proposed algorithm is capable of estimating the trajectory accurately with low estimation error.
Femmes de la technopole : des choix résidentiels à stratégie nuancée ? (2004)

INTRODUCTIONLa technopole, ici métropole technopolitaine, est le dernier avatar de la grande ville liée à une forme d’activité économique spécifique. Déjà lors de la première révolution industrielle, la ville a été lieu attractif pour les hommes ruraux venus travailler dans les usines, mais aussi pour les jeunes femmes issues des campagnes qui n’ont cessé d’abonder au fil du temps les emplois de service à l’origine dans les familles bourgeoises puis dans le monstrueux « fourre-tout du tertia...
Secondary ion mass spectrometry: principles and applications (1990)

Introducing secondary ion mass spectrometry, John Vickerman the SIMS phenomenon - the experimental parameters, John Vickerman SIMS - the theoretical models, John Vickerman SIMS instrumentation, A.J.Eccles SIMS depth profiling of semiconductors, D.S.McPhail the application of static SIMS in surface science, John Vickerman static SIMS for applied surface analysis, Nicola M.Reed SIMS imaging, P.Humphrey SIMS-related techniques, John Vickerman.
Security Risk Assessment and Management as Technical Debt (2019)

The endeavor to achieving software security consists of a set of risk-based security engineering processes during software development. In iterative software development, the software design typically evolves as the project matures, and the technical environment may undergo considerable changes. This increases the work load of identifying, assessing and managing the security risk by each iteration, and after every change. Besides security risk, the changes also accumulate technical debt, an allegory for postponed or sub-optimally performed work. To manage the security risk in software development efficiently, and in terms and definitions familiar to software development organizations, the concept of technical debt is extended to contain security debt. To accommodate new technical debt with potential security implications, a security debt management approach is introduced. The selected approach is an extension to portfolio-based technical debt management framework. This includes identifying security risk in technical debt, and also provides means to expose debt by security engineering techniques that would otherwise remained hidden. The proposed approach includes risk-based extensions to prioritization mechanisms in existing technical debt management systems. Identification, management and repayment techniques are presented to identify, assess, and mitigate the security debt.