gebhart/patrepeval huggingface dataset:
Knowledge Consistency Maintenance Architecture for Bullwhip Effect in Global SCM (2008)

With e-business and enterprise global layout trend, SCM efficiency is a key of improving competitions. In global transnational enterprise, widely area duplicates inconsistency issues became seriously in the SCM as a result of using caching, middleware and database replication technologies to improve bullwhip effect problem. We proposed novel global knowledge message consistency model - DHWSRP (distributed heterogeneous Web service routing based portal) that can ripple propagate updating SCM copy that existed in internal heterogeneity of enterprise database with specified OKMS (original knowledge message source) partially dependency relationships. The thesis also proposed a new scalable replica routing policies dynamic reconfiguration distributed forwarding data path in hierarchical enterprises knowledge database. On the basis of the ubiquitous data consistency framework, many active updating flows can be pushed by AI agents using real time, periodic, reservation, and queuing with priority/degradation/preemption etc. methods. Apply scenario can eliminate in GSCM (global SCM).
Acute breath-holding does not improve 3km cycling time trial performance (2019)

Introduction. Intense exercise evokes a spleen contraction releasing red blood cells into the blood circulation. This improves oxygen transport capacity which is beneficial for performance. The same mechanism is found following acute apnea, increasing [Hb] by 2 to 5%. Therefore, the aim was to examine whether pre-race apnea can improve performance in a 3km time trial (TT) through apnea-induced spleen contraction before the onset of exercise. Methods . 11 recreationally active subjects performed 3km cycling TTÂ following a 10 minute warm-up in 3 different conditions: an apnea (one maximal static apnea finishing 3 minutes before TT), control and placebo condition. Power output, maximal heart rate and VO 2 uptake were continuously measured. Lactate and venous [Hb] were sampled at baseline, after warm-up and before TT. Results. Interaction effects (F=3.475, p=0.049) for [Hb] values revealed that including an apnea during the rest period evoked a positive change in [Hb] pattern. With completion times of 264.8Â±14.1s for apnea, 263.9Â±12.9s control and 264.0Â±15.8s placebo, performance did not differ between conditions (F=0.250, p=0.840). Power output (F=0.406, p= 0.584) and peak physiological parameters did not differ either (VO 2 p=0.602; heart rate p=0.757; lactate p=0.185). HR and VO 2 responses during TT also were not different (p>0.05), while power was significantly lower in the last 250m interval in AP compared to CO and PB (F=5.940, p=0.010). Conclusion. Although a small positive impact on the Hb values was seen, implementing a single apnea in the warm-up did not change the physiological parameters during nor improve the TT performance.
10000 times volume reduction for fluorescence correlation spectroscopy using nano-antennas (2008)

We present an experimental and theoretical study of a new scheme for Near-Field Fluorescence Correlation Spectroscopy that, using the field enhancement by optical nanoantennas, allows the reduction of the observation volume 4 orders of magnitude below the diffraction limit. This reduction can be used in two different ways: to increase the sample concentration and to improve the spatial resolution of the dynamics under study. Our experimental results using individual gold nanoparticles and a 150 microM Rose Bengal solution in glycerol confirm the volume reduction.
Liposomes with Prolonged Blood Circulation and Selective Localization in Klebsiella pneumoniae-Infected Lung Tissue (1993)

Studies of two types of small liposomes, differing with respect to their lipid composition in terms of bilayer fluidity, charge, and hydrophilicity of the liposomal surface, were done to evaluate their usefulness for delivery of encapsulated therapeutic agents to sites of infection. The liposomes showed substantial localization in infected lung tissue after intravenous administration. This was demonstrated in a model of unilateral Klebsiella pneumoniae pneumonia in rats, in which the left lung was infected but the right lung of the same animal developed no infection. The degree of localization in the infected left lung was different for the two types of liposomes. For the liposome type with the longer blood residence time, containing a surface coating of polyethylene glycol, localization in the infected left lung was dependent on the liposomal dose, correlated with the intensity of infection, and reached 9% of the injected liposomal dose in severely infected rats.
ML-Leaks: Model and Data Independent Membership Inference Attacks and Defenses on Machine Learning Models (2019)

Machine learning (ML) has become a core component of many real-world applications and training data is a key factor that drives current progress. This huge success has led Internet companies to deploy machine learning as a service (MLaaS). Recently, the first membership inference attack has shown that extraction of information on the training set is possible in such MLaaS settings, which has severe security and privacy implications.
Cell-Surface GRP78 and its Antibodies: Pathologic and Therapeutic Roles in Cancer (2010)

<p>The chaperone protein GRP78 is primarily expressed in the endoplasmic reticulum, but it is also aberrantly expressed on the surface of cells under pathological conditions. One the cell membrane, GRP78 acts as a signaling molecule with unique properties. The amino-terminal domain acts as a growth factor receptor-like protein, while the carboxyl-terminal domain functions as a death-signaling receptor-like protein to extrinsically induce apoptosis. Autoantibodies that react with cell-surface GRP78 on many tumor cell lines occur in the sera of patients with prostate cancer, melanoma, and ovarian cancer. These autoantibodies are a negative prognostic factor in prostate cancer and melanoma, and when purified, stimulate tumor cell proliferation in vitro. It is unclear, however, whether these IgGs are merely a biomarker, or if they actually promote tumor growth in vivo. We immunized C57Bl/6 mice with recombinant GRP78 and then implanted the B16F1 murine melanoma cell line as flank tumors. We employed the antisera from these mice for in vitro cell signaling and proliferation assays. The immunodominant epitope in human cancer patients was well represented in the antibody repertoire of these immunized mice. We observed significantly accelerated tumor growth, as well as shortened survival in GRP78-immunized mice as compared to controls. Furthermore, antisera from these mice, as well as purified anti-GRP78 IgG from similarly immunized mice, stimulate Akt phosphorylation and proliferation in B16F1 and human DM6 melanoma cells in culture. These studies demonstrate a causal link between a humoral response to GRP78 and the progression of cancer in a murine melanoma model. They support the hypothesis that such autoantibodies are involved in the progression of human cancers and are not simply a biomarker. Because GRP78 is present on the surface of many types of cancer cells, this hypothesis has broad clinical and therapeutic implications.</p><p>We generated and characterized a panel of monoclonal murine antibodies (mAbs) against GRP78 with the goal of identifying therapeutic candidate IgGs. We developed three stable hybridomas that produce interesting antibodies. The N88 IgG reacts with the NH2-terminal domain and is an agonist. The C38 IgG reacts with the COOH-terminal domain and is an antagonist of NH2-terminal signaling. The C107 IgG binds the COOH-terminal domain and induces apoptosis. </p><p>We examined the effect of these three mAbs on the growth of B16 flank tumors. N88 accelerated and C107 slowed tumor growth, while C38 had no net effect. We are currently developing these antibodies and derivatives thereof as therapeutics for melanoma as well as for cancers of the brain, breast, ovary, and prostate. In fact, any tumor cell that over-expresses GRP78 on its surface is a potential therapeutic target for our future studies.</p>
On the performance of MC-CDMA with transmit diversity over fast frequency selective fading channels (2005)

Space-time (ST) block coded multi-carrier code division multiple access (MC-CDMA) has been proposed as an attractive solution for high data rate transmission in a multipath fading environment. A space-time-frequency (STF) block coded MC-CDMA scheme is presented. The proposed scheme is a four-branch transmitter diversity system which utilizes block codes formed over the space, time and frequency domains. The performance of the STF block coded MC-CDMA scheme is then compared with that of the ST block coded MC-CDMA and SF block coded MC-CDMA systems with four transmitting antennas. It is shown that the proposed STF block coded MC-CDMA scheme gives better performance over fast frequency selective fading channels.
Support for Cell Broadcast as Global Emergency Alert System (2007)

Cell Broadcast (CB) is a possible technical realisation of a global emergency alert system. It is a technique used for sending short text messages to all mobile stations (MSs) in a defined geographical area. An potential effect of using CB is the increase in battery consumption of the MS due to the fact that an extra channel has to be used to make the service available even when the network is otherwise congested. Another part of the service which leads to a potential problem is making CB messages available in different languages. Investigating these problems is the objective of this thesis and the studies it includes. During the first part of the thesis, we measured the battery consumption of MSs in different modes of operation in order to analyse how CB affects the amount of current drained. The tests showed that battery consumption increased only slightly when CB messages were being received at the MS. Although some of the results can be, and are, discussed, we believe that CB would have a small effect on the power consumption of an MS, particularly in a context where it would be used for emergency warning messages only. This mentioned, it would however be wishful to confirm the conclusions further through the realisation of long-term testing. The second part of the thesis deals with the investigation of the MSs’ support for CB messages with different coding schemes. Based on the investigation’s result, we have come to the conclusion that in the long term the usage of different coding schemes on the same channel is preferred. However, the usage of one, global, emergency channel is hard to realise since that requires a standardisation between all countries. In our opinion this may be achieved first in the long run and until then, the usage of separate channels seems to be necessary.
Hybrid LIDAR-radar: Seeing through the scatter (2000)

Improvements in optical transmitter and receiver design and development have resulted in an increased use of optical techniques for remote sensing applications. A hybrid LIDAR-radar system has been developed that combines the detection and signal-processing techniques of radar with the optical propagation characteristics of LIDAR. The hybrid LIDAR-radar approach has been applied to both pulsed- and continuous-wave underwater laser imaging systems. These two systems are the modulated-pulse LIDAR (MPL) system and the modulated-laser line scanner (MLLS).
Computational and Experimental Investigation of Ti Substitution in Li<sub>1</sub>(Ni<sub><i>x</i></sub>Mn<sub><i>x</i></sub>Co<sub>1–2<i>x</i>–<i>y</i></sub>Ti<sub><i>y</i></sub>)O<sub>2</sub> for Lithium Ion Batteries (2014)

Aliovalent substitutions in layered transition-metal cathode materials has been demonstrated to improve the energy densities of lithium ion batteries, with the mechanisms underlying such effects incompletely understood. Performance enhancement associated with Ti substitution of Co in the cathode material Li1(NixMnxCo1-2x)O2 were investigated using density functional theory calculations, including Hubbard-U corrections. An examination of the structural and electronic modifications revealed that Ti substitution reduces the structural distortions occurring during delithiation due to the larger cation radius of Ti(4+) relative to Co(3+) and the presence of an electron polaron on Mn cations induced by aliovalent Ti substitution. The structural differences were found to correlate with a decrease in the lithium intercalation voltage at lower lithium concentrations, which is consistent with quasi-equilibrium voltages obtained by integrating data from stepped potential experiments. Further, Ti is found to suppress the formation of a secondary rock salt phase at high voltage. Our results provide insights into how selective substitutions can enhance the performance of cathodes, maximizing the energy density and lifetime of current Li ion batteries.
3D vibration and stress analysis of insulators (2017)

Numerous dedicated computer packages are of much help at insulator designing process. Making a digital model of an insulator and then performing computer simulation for the phenomena occurring both inside and outside of it, becomes nowadays a vital information source on the insulator behavior at established (both given and analyzed) operational conditions. Such a process appears to be necessary at the stage of insulator design process. The computer simulation results can verify the data obtained during actual insulator operation or laboratory tests, which make it possible to do suitable adjustments still at the design stage in order to include some innovative solutions, operational features, improvements as well as to get some economical advantages resulting from them. Selected problems associated with static electricity and mechanical phenomena occurring at insulator operation have been addressed in this paper. The calculations have been made with ANSYS Multipurpose Finite Elements Method Package as well as the MSC/PATRAN v.8.5, the latter used mainly for mechanical purposes [6].
Towards context adaptive privacy decisions in ubiquitous computing (2012)

In ubiquitous systems control of privacy settings will be increasingly difficult due to the pervasive nature of sensing and communication capabilities. We identify challenges for privacy decisions in ubiquitous systems and propose a system for in situ privacy decision support. When context changes occur, the system adapts a user's privacy preferences to the new situation. As a consequence, recommendations can be offered to the user or sharing behavior can be automatically adjusted to help the user maintain a desired level of privacy. The system learns from user interaction and behavior to improve decision accuracy. In this paper, we outline the main components of our system and illustrate its operation with an ambient assisted living use case.
Antimicrobial cytocompatible pentaerythritol triacrylate‐co‐trimethylolpropane composite scaffolds for orthopaedic implants (2014)

ABSTRACT As of 2010, 5.3 million orthopedic surgeries are performed each year, and this number is expected to increase to 6.2 million by 2020. On average, 27.7% of all orthopedic surgeries result in infection which often leads to osteomyelitis and the loss of supporting bone. In this study, we describe two synthetic bone grafts, or augmentation methods, for a biodegradable, silver nanoparticle (SNPs) containing antimicrobial scaffolds composed of pentaerythritol triacrylate‐ co ‐trimethylolpropane tris (3‐mercaptopropionate) (PETA) and hydroxyapatite (HA). This osteoinductive and degradable material is designed to stimulate proliferation of bone progenitor cells, and provide controlled release of antimicrobial components. The first method, denoted as the “incorporating method,” involves dissolving SNPs in ethanol, butanol, or isopropanol and directly incorporating the particles into the scaffold prior to polymerization. The second method, “coating method,” involves submerging fabricated scaffolds into their respective SNPs‐solution and mixing for 24 h. The coating method allowed better distribution and release of SNPs from the surface of the composites when exposed to extracellular media. The in vitro release of silver for both methods was quantified by inductively coupled plasma optical emission spectroscopy (ICP‐OES). The scaffolds made by means of the coating method showed increased release of silver with respect to time; no silver leached from the scaffolds formed by the incorporating method. Use of Alamar Blue assay demonstrated that the SNPs incorporation did not affect cell viability when tested with hASCs. The scaffolds formed by the coating method inhibited the proliferation of Staphylococcus aureus 99.5% and Escherichia coli by 99.9% within 24 h. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 41099.
When network coding and dirty paper coding meet in a cooperative ad hoc network (2008)

We develop and analyze new cooperative strategies for ad hoc networks that are more spectrally efficient than classical decode & forward (DF) protocols. Using analog network coding, our strategies preserve the practical half-duplex assumption but relax the orthogonality constraint. The introduction of interference due to non-orthogonality is mitigated thanks to precoding, in particular dirty paper coding. Combined with smart power allocation, our cooperation strategies allow to save time and lead to a more efficient use of the bandwidth and to improved network throughput with respect to classical repetition-DF and parallel-DF.
Unique translation initiation of mRNAs-containing TISU element (2011)

Translation Initiator of Short 5' UTR (TISU) is a unique regulatory element of both transcription and translation initiation. It is present in a sizable number of genes with basic cellular functions and a very short untranslated region (5' UTR). Here, we investigated translation initiation from short 5' UTR mRNAs with AUG in various contexts. Reducing 5' UTR length to the minimal functional size increases leaky scanning from weak and strong initiators but hardly affects translation initiation and ribosomal binding directed by TISU. Ribosome interaction with TISU mRNA is cap dependent and involves AUG downstream nucleotides that compensate for the absent 5' UTR contacts. Interestingly, eIF1 inhibits cap-proximal AUG selection within weak or strong contexts but not within TISU. Furthermore, TISU-directed translation is unaffected by inhibition of the RNA helicase eIF4A. Thus, TISU directs efficient cap-dependent translation initiation without scanning, a mechanism that would be advantageous when intracellular levels of eIF1 and eIF4A fluctuate.
Serum Complement C3 Predicts Renal Arteriolosclerosis in Non-Diabetic Chronic Kidney Disease (2012)

Aim: Complement C3 (C3) is one of the major mediators of inflammation. Serum C3 has been shown to be correlated with the presence of atherosclerosis. We examined whether the serum C3 level might be correlated with the severity of renal arteriolosclerosis in patients with chronic kidney disease (CKD).Methods: Non-diabetic CKD (stages 1-3) patients who underwent renal biopsy were enrolled in this study. Renal arteriolosclerosis was defined by the presence of hyaline changes and vessel wall thickening in the renal biopsy specimens. We examined whether the serum C3 level might be correlated with the severity of renal arteriolosclerosis in CKD patients.Results: A total of 208 CKD patients (age 36.0±13.6 years; 94 male) who underwent renal biopsy were included. Univariate analysis showed that the serum C3 level was positively correlated with age, body mass index, blood pressure and the serum triglyceride, LDL cholesterol and CRP (p<0.001). The serum C3 level was also inversely correlated with serum HDL cholesterol (p<0.001). Multiple regression analysis identified that the serum C3 (p=0.043) as well as age (p<0.001), serum uric acid (p=0.009) and eGFR (p= 0.025) were independently associated with the severity of renal arteriolosclerosis.Conclusion: Our results suggest that the serum C3 level is a reliable marker of renal arteriolosclerosis. Components of metabolic syndrome were also correlated with the serum C3 level. Inflammation or metabolic syndrome may contribute to CKD through influencing the rate of progression of renal arteriolosclerosis.
Review of Accelerator-based Boron Neutron Capture Therapy Machines (2016)

Boron Neutron Capture Therapy (BNCT) is a promising method for cancer therapy. A few accelerator-based BNCT projects are in progress in Japan, and plans for such systems are discussed in Europe, China, Taiwan and Korea. To obtain sufficient epi-thermal neutron flux, 30-50 kW of proton beam power is required. This talk reviews the present situation of the BNCT projects in the world. Key issues for the stable production of epi-thermal neutrons for medical applications are discussed. This includes the type of accelerator (linac or cyclotron), the selection of proton energy (3 MeV, 8 MeV, or 30 MeV), the coice of target (Li or Be) and moderator.
Triboluminescent materials for smart sensors (2011)

Since the beginning of 21st Century, scientists and engineers have been investigating triboluminescent materials for use in smart impact sensors. One of the brightest triboluminescent materials found thus far is europium dibenzoylmethide triethylammonium (EuD4TEA). This material was discovered by Hurt in 1966 and is bright enough to be seen in daylight. Through innovative design of the material synthesis steps and by exchanging europium chloride for europium nitrate, the triboluminescent emission was increased by over 80%. In addition, the material yield was increased, as chloride washing is not required. Here, we discuss the new synthesis process, triboluminescent results, and future applications of EuD4TEA phosphors.
Conceptual mapping as a communication tool of legal requirements (2016)

Requirements elicitation is a important task for success on project of systems development. It is essential that the development team has tools that assist in communication and negotiation with stakeholders. The Juridical Domain-Specific has a large volume of information and its own peculiar language that can harm the process of communication between the development team and stakeholders. This work investigates the use of concept maps as a tool for conceptual modeling of the juridical domain, considering the complexities and peculiarities of the domain. Two experiments are performed with system developers and legal experts, respectively, to analyze the use of concept maps within this context. As result, there is the concept maps provide better understanding regarding the conceptual legal framework, indicating the feasibility of its use to improve the process for defining requirements for the juridical domain.
Spacer defined double patterning for sub-72 nm pitch logic technology (2010)

In order to extend the optical lithography into sub-72 nm pitch regime, spacer defined double patterning as a self-aligning process option was investigated. In the sidewall defined spacer process, spacer material was deposited directly on the resist to achieve process simplification and cost effectiveness. For the spacer defined double patterning, core mandrel CD uniformity is proven to be a main contributor to pitch-walking and defined a new lithographic process window. Here, the aerial image log-slope is shown to be a measurable predictor of CD uniformity and sidewall angle of the resist pattern. Through resist screening and illumination optimization, resist core-mandrel of 2.5 nm CD uniformity across a focus range more than 200 nm with ± 3.5 % exposure latitude was developed having sidewall control close to the normal. Finally etch revealed that pitch-walking post pitch split can be suppressed below 2 nm within ± 2.5 % exposure latitude.