gebhart/patrepeval huggingface dataset:
Mid-call, multi-party, and multi-device telecommunication features and their interactions (2011)

Mid-call telecommunication features act only after an initial media connection has been set up. Many mid-call features perform complex functions such as handling multiple far parties and multiple devices. They cause many important feature interactions that are little known and poorly understood. Using the example of personal features associated with a mobile phone, this paper presents a general method for analyzing the interactions of mid-call features with each other and with other features in a service. The paper discusses how to determine the most desirable behavior of interacting features. It also shows, as a proof of existence, how to manage these interactions in pipes-and-filter implementations of telecommunication services.
Biochemical Characterization of NotB as an FAD-Dependent Oxidase in the Biosynthesis of Notoamide Indole Alkaloids (2011)

Notoamides produced by Aspergillus spp. bearing the bicyclo[2.2.2]diazaoctane core structure with unusual structural diversity represent a compelling system to understand the biosynthesis of fungal prenylated indole alkaloids. Herein, we report the in vitro characterization of NotB, which catalyzes the indole 2,3-oxidation of notoamide E (13), leading to notoamides C (11) and D (12) through an apparent pinacol-like rearrangement. This unique enzymatic reaction with high substrate specificity, together with the information derived from precursor incorporation experiments using [(13)C](2)-[(15)N](2) quadruply labeled notoamide S (10), demonstrates 10 as a pivotal branching point in notoamide biosynthesis.
A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent (2013)

The stress-induced HSP70 is an ATP-dependent molecular chaperone that plays a key role in refolding misfolded proteins and promoting cell survival following stress. HSP70 is marginally expressed in nontransformed cells, but is greatly overexpressed in tumor cells. Silencing HSP70 is uniformly cytotoxic to tumor but not normal cells; therefore, there has been great interest in the development of HSP70 inhibitors for cancer therapy. Here, we report that the HSP70 inhibitor 2-phenylethynesulfonamide (PES) binds to the substrate-binding domain of HSP70 and requires the C-terminal helical "lid" of this protein (amino acids 573-616) to bind. Using molecular modeling and in silico docking, we have identified a candidate binding site for PES in this region of HSP70, and we identify point mutants that fail to interact with PES. A preliminary structure-activity relationship analysis has revealed a derivative of PES, 2-(3-chlorophenyl) ethynesulfonamide (PES-Cl), which shows increased cytotoxicity and ability to inhibit autophagy, along with significantly improved ability to extend the life of mice with pre-B-cell lymphoma, compared with the parent compound (P = 0.015). Interestingly, we also show that these HSP70 inhibitors impair the activity of the anaphase promoting complex/cyclosome (APC/C) in cell-free extracts, and induce G2-M arrest and genomic instability in cancer cells. PES-Cl is thus a promising new anticancer compound with several notable mechanisms of action.
Improved superimposed training based channel estimation for MIMO-OFDM systems with quantized feedback (2010)

This work pertains to the use of superimposed training (ST) in closed loop multiple input multiple output (MIMO) orthogonal frequency division multiplexing (OFDM) systems. A novel method consisting of a technique to refine the channel estimate at the transmitter in a ST based closed loop MIMO-OFDM system is proposed. The estimate is refined at the transmitter by making use of the previous data that was transmitted. This significantly reduces the data interference in the channel estimate and hence improves performance. Two factors in general affect all transmitter side techniques that make use of the fed back channel coefficients. One is the quantization error affecting the channel estimate. The other is the channel variations that may render the fed back channel coefficients outdated for further use. The effect of these factors on the proposed refined channel estimation scheme is discussed in detail. Simulation results are presented in terms of the mean squared estimation error (MSEE) demonstrating the usefulness of the proposed scheme.
Real-Time Video Super-Resolution with Spatio-Temporal Networks and Motion Compensation (2017)

Convolutional neural networks have enabled accurate image super-resolution in real-time. However, recent attempts to benefit from temporal correlations in video super-resolution have been limited to naive or inefficient architectures. In this paper, we introduce spatio-temporal sub-pixel convolution networks that effectively exploit temporal redundancies and improve reconstruction accuracy while maintaining real-time speed. Specifically, we discuss the use of early fusion, slow fusion and 3D convolutions for the joint processing of multiple consecutive video frames. We also propose a novel joint motion compensation and video super-resolution algorithm that is orders of magnitude more efficient than competing methods, relying on a fast multi-resolution spatial transformer module that is end-to-end trainable. These contributions provide both higher accuracy and temporally more consistent videos, which we confirm qualitatively and quantitatively. Relative to single-frame models, spatio-temporal networks can either reduce the computational cost by 30% whilst maintaining the same quality or provide a 0.2dB gain for a similar computational cost. Results on publicly available datasets demonstrate that the proposed algorithms surpass current state-of-the-art performance in both accuracy and efficiency.
<title>Multiple wavelength vertical-cavity laser arrays with wide wavelength span and high uniformity</title> (1996)

Multiple-wavelength vertical-cavity surface-emitting laser arrays are fabricated by using a patterned-substrate growth technique and a location-resolvable in situ optical calibration method in a molecular beam epitaxy system. We achieved a record wavelength span of 62.7 nm, highly uniform threshold currents with an average of 2.16 +/- 0.81 mA, and high repeatability of wavelength spacing between 15 arrays with sharp wavelength shift rate of 117.14 nm/mm. Accuracy of 0.28% of high and low wavelength limits and a 2.66 angstroms wavelength standard deviation from 4 X 35 arrays are also obtained.
Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo (2000)

Matrix metalloproteinase 2 (MMP2) can associate with integrin alpha(v)beta3 on the surface of endothelial cells, thereby promoting vascular invasion. Here, we describe an organic molecule (TSRI265) selected for its ability to bind to integrin alphav(v)beta3 and block alpha(v)beta3 interaction with MMP2. Although disrupting alpha(v)beta3/MMP2 complex formation, TSRI265 has no effect on alpha(v)beta3 binding to its extracellular matrix ligand vitronectin and does not influence MMP2 activation or catalytic activity directly. However, TSRI265 acts as a potent antiangiogenic agent and thereby blocks tumor growth in vivo. These findings suggest that activated MMP2 does not facilitate vascular invasion during angiogenesis unless it forms a complex with alpha(v)beta(3) on the endothelial cell surface. By disrupting endothelial cell invasion without broadly suppressing cell adhesion or MMP function, the use of compounds such as TSRI265 may provide a novel therapeutic approach for diseases associated with uncontrolled angiogenesis.
U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21 (2014)

These studies identify U1 snRNP pathologic changes in brain of early onset genetic forms of AD. Since dominant genetic mutations and trisomy 21 result in dysfunctional amyloid processing, the findings suggest that aberrant β-amyloid processing may influence U1 snRNP aggregate formation.
Self-referential phase reset based on inferior olive oscillator dynamics (2004)

The olivo-cerebellar network is a key neuronal circuit that provides high-level motor control in the vertebrate CNS. Functionally, its network dynamics is organized around the oscillatory membrane potential properties of inferior olive (IO) neurons and their electrotonic connectivity. Because IO action potentials are generated at the peaks of the quasisinusoidal membrane potential oscillations, their temporal firing properties are defined by the IO rhythmicity. Excitatory inputs to these neurons can produce oscillatory phase shifts without modifying the amplitude or frequency of the oscillations, allowing well defined time-shift modulation of action potential generation. Moreover, the resulting phase is defined only by the amplitude and duration of the reset stimulus and is independent of the original oscillatory phase when the stimulus was delivered. This reset property, henceforth referred to as selfreferential phase reset, results in the generation of organized clusters of electrically coupled cells that oscillate in phase and are controlled by inhibitory feedback loops through the cerebellar nuclei and the cerebellar cortex. These clusters provide a dynamical representation of arbitrary motor intention patterns that are further mapped to the motor execution system. Being supplied with sensory inputs, the olivo-cerebellar network is capable of rearranging the clusters during the process of movement execution. Accordingly, the phase of the IO oscillators can be rapidly reset to a desired phase independently of the history of phase evolution. The goal of this article is to show how this selfreferential phase reset may be implemented into a motor control system by using a biologically based mathematical model.
Wearable Wireless Telemetry System for Implantable Bio-MEMS Sensors (2006)

In this paper, a telemetry and contact-less powering system consisting of an implantable bio-MEMS sensor with a miniature printed square spiral chip antenna and an external wearable garment with printed loop antenna is investigated. The implantable chip antenna and the wearable garment pick-up antenna are in close proximity to each other and hence couple inductively through their near-fields and behave as the primary and the secondary circuits of a transformer, respectively. The numerical and experimental results are graphically presented, and include the design parameter values as a function of the geometry and the relative magnetic near-field intensity as a function of the angle, for the implantable chip antenna
A Miniature Laser Desorption/Ionization Time-of-Flight Mass Spectrometer for in Situ Analysis of Mars Surface Composition and Identification of Hazard in Advance of Future Manned Exploration (2012)

Future landed missions to Mars will be guided by two strategic directions: (1) sample return to Earth, for comprehensive compositional analyses, as recommended by the 2011 NRC Planetary Decadal Survey; and (2) preparation for human exploration in the 2030s and beyond, as laid out by US space policy. The resultant mission architecture will likely require high-fidelity in situ chemical/organic sample analyses within an extremely constrained resource envelope. Both science goals (e.g., MEPAG Goal 1, return sample selection, etc.) as well as identification of any potential toxic and biological hazards to humans, must be addressed. Over the past several years of instrument development, we have found that the adaptable, compact, and highly capable technique of laser desorption/ionization time-of-flight mass spectrometry (LD-TOF-MS) has significant potential to contribute substantially to these dual objectives. This concept thus addresses Challenge Area 1: instrumentation and Investigation Approaches.
InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared (2009)

We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700-900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging.
Four-Way Microstrip-Based Power Combining for Microwave Outphasing Power Amplifiers (2014)

A lossless multi-way outphasing and power combining system for microwave power amplification is presented. The architecture addresses one of the primary drawbacks of Chireix outphasing; namely, the sub-optimal loading conditions for the branch power amplifiers. In the proposed system, four saturated power amplifiers interact through a lossless power combining network to produce nearly resistive load modulation over a 10:1 range of output powers. This work focuses on two microstrip-based power combiner implementations: a hybrid microstrip/discrete implementation using a combination of microstrip transmission line sections with discrete shunt elements, and an all-microstrip implementation incorporating open-circuited radial stubs. We demonstrate and compare these techniques in a 2.14 GHz power amplifier system. With the all-microstrip implementation, the system demonstrates a peak CW drain efficiency of 70% and drain efficiency of over 60% over a 6.5-dB outphasing output power range with a peak power of over 100 W. We demonstrate W-CDMA modulation with 55.6% average modulated efficiency at 14.1 W average output power for a 9.15-dB peak to average power ratio (PAPR) signal. The performance of this all-microstrip system is compared to that of the proposed hybrid microstrip/discrete version and a previously reported implementation in discrete lumped-element form.
Sampling Conditions for Conforming Voronoi Meshing by the VoroCrust Algorithm (2018)

We study the problem of decomposing a volume with a smooth boundary into a collection of Voronoi cells. Unlike the dual problem of conforming Delaunay meshing, a principled solution to this problem for generic smooth surfaces remained elusive. VoroCrust leverages ideas from weighted <i>α</i>-shapes and the power crust algorithm to produce unweighted Voronoi cells conforming to the surface, yielding the first provably-correct algorithm for this problem. Given a <i>κ</i>-sparse <i>ε</i>-sample, we work with the balls of radius <i>δ</i> times the local feature size centered at each sample. The corners of the union of these balls on both sides of the surface are the Voronoi sites and the interface of their cells is a watertight surface reconstruction embedded in the dual shape of the union of balls. With the surface protected, the enclosed volume can be further decomposed by generating more sites inside it. Compared to clipping-based algorithms, VoroCrust cells are full Voronoi cells, with convexity and fatness guarantees. Compared to the power crust algorithm, VoroCrust cells are not filtered, are unweighted, and offer greater flexibility in meshing the enclosed volume by either structured or randomly genenerated samples.
Facile Synthesis of Battery-Type CuMn2O4 Nanosheet Arrays on Ni Foam as an Efficient Binder-Free Electrode Material for High-Rate Supercapacitors (2023)

The development of battery-type electrode materials with hierarchical nanostructures has recently gained considerable attention in high-rate hybrid supercapacitors. For the first time, in the present study novel hierarchical CuMn<sub>2</sub>O<sub>4</sub> nanosheet arrays (NSAs) nanostructures are developed using a one-step hydrothermal route on a nickel foam substrate and utilized as an enhanced battery-type electrode material for supercapacitors without the need of binders or conducting polymer additives. X-ray diffraction, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques are used to study the phase, structural, and morphological characteristics of the CuMn<sub>2</sub>O<sub>4</sub> electrode. SEM and TEM studies show that CuMn<sub>2</sub>O<sub>4</sub> exhibits a nanosheet array morphology. According to the electrochemical data, CuMn<sub>2</sub>O<sub>4</sub> NSAs give a Faradic battery-type redox activity that differs from the behavior of carbon-related materials (such as activated carbon, reduced graphene oxide, graphene, etc.). The battery-type CuMn<sub>2</sub>O<sub>4</sub> NSAs electrode showed an excellent specific capacity of 125.56 mA h g<sup>-1</sup> at 1 A g<sup>-1</sup> with a remarkable rate capability of 84.1%, superb cycling stability of 92.15% over 5000 cycles, good mechanical stability and flexibility, and low internal resistance at the interface of electrode and electrolyte. Due to their excellent electrochemical properties, high-performance CuMn<sub>2</sub>O<sub>4</sub> NSAs-like structures are prospective battery-type electrodes for high-rate supercapacitors.
<title>Real-time active range finder using light intensity modulation</title> (1999)

We propose a new real-time active range finder system, which operates at a video frame rate. Our system consist of a laser line pattern marker, a rotating mirror, a camera with an optical narrow bandpass filter, and a pipe-lined image signal processor. The vertical laser line pattern is horizontally scanned by the video-synchronized rotating mirror. The pattern is modulated with alternating a monotone decreasing intensity function and a monotone increasing function. The bandpass filter selectively transmits the laser light to decrease the disturbance of background light. Depth images are obtained using the intensity ratio of successive video field images, the coordinates of each pixel, and the baseline length. The intensity ratio specifies a line pattern in a plane. Meanwhile, the coordinates of each pixel specify a line that goes through the pixel position on the CCD and the center of the lens. Depth is calculated as an intersection point on the specified plane and line. The image signal processor can perform the above calculation using LUTs within a video frame. In this paper, we evaluate the measurable range, precision, and color properties of our system. Experimental results show that a two meters measurable range is obtained wit a 50 mW laser power, the standard deviations of the depth images with 5 by 5 median filtering are about 1 percent of the measured depth, and the object color has little effect on the measured depth except when the reflectance of the object is very small.
Balancing method for use in multiple-span rotor shaft system and balancing system using same (1979)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Motohiro Shiga, Fumio Fujisawa, Kazuo Sato, Kouki Shiohata, Mazakazu Takasumi, Tsuguaki Koga; Balancing method for use in multiple‐span rotor shaft system and balancing system using same. J. Acoust. Soc. Am. 1 February 1979; 65 (2): 559. https://doi.org/10.1121/1.382395 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Electrooptical Rf Phase Shifter for Antenna Applications (1985)

A new class of microwave/optical antenna makes use of fiber-optic transmission lines in the antenna feed.1 Rapid electronic beam-steering is an important goal for these antennas, especially for phased arrays. To reach that goal, active fibercoupled optical devices are needed to adjust the microwave electrical phase of neighboring radiant elements in the array. This paper describes an optical heterodyne device that can produce several cycles of rf/microwave phase shift in response to voltage commands. The device can be constructed on a small (1×2-cm) integrated-optical chip, enabling planar integration of several low-voltage phase shifters.
Culture and Genetic Modification of Mouse Germline Stem Cells (2007)

Spermatogenesis depends on a population of cells called spermatogonial stem cells, which self-renew to support male reproduction throughout life. In 2003, the long-term culture of spermatogonial stem cells of mice proved to be successful. In the presence of glial cell-line-derived neurotrophic factor, germline stem (GS) cells were established from postnatal mouse testis. These cells proliferated over a 2-year period (>10(85)-fold) and restored fertility to congenitally infertile recipient mice following transplantation into the seminiferous tubules. Unlike other germline cells that often acquire genetic and epigenetic changes in vitro, the GS cells retained their euploid karyotype and androgenetic imprint during the 2-year experimental period, and they produced normal fertile offspring. Mutagenization of the GS cells was successful using gene trapping and gene targeting vectors to produce homozygous knockout offspring, thereby providing a new approach to germline modification. In the course of the gene targeting experiments, establishment of embryonic-stem (ES)-like cells was also successful [i.e., multipotent germline stem (mGS) cells] from postnatal mouse testis. These mGS cells were phenotypically similar to the ES/embryonic germ cells, except for their genomic imprinting pattern. They differentiated into various types of somatic cells in vitro under the conditions used to induce the differentiation of the ES cells, and the mGS cells formed germline chimeras when injected into blastocysts. These new spermatogonial stem-cell lines will be useful for studying the mechanism of spermatogenesis, and they have important implications for developing new transgenic or medical technologies.
The<i>Moraxella catarrhalis</i>Immunoglobulin D-Binding Protein MID Has Conserved Sequences and Is Regulated by a Mechanism Corresponding to Phase Variation (2003)

The prevalence of the Moraxella catarrhalis immunoglobulin D (IgD)-binding outer membrane protein MID and its gene was determined in 91 clinical isolates and in 7 culture collection strains. Eighty-four percent of the clinical Moraxella strains expressed MID-dependent IgD binding. The mid gene was detected in all strains as revealed by homology of the signal peptide sequence and a conserved area in the 3' end of the gene. When MID proteins from five different strains were compared, an identity of 65.3 to 85.0% and a similarity of 71.2 to 89.1% were detected. Gene analyses showed several amino acid repeat motifs in the open reading frames, and MID could be called a putative autotransport protein. Interestingly, homopolymeric [polyguanine [poly(G)]] tracts were detected at the 5' ends within the open reading frames. By flow cytometry, using human IgD and fluorescein isothiocyanate-conjugated anti-IgD polyclonal antibodies, most strains showed two peaks: one high- and one low-intensity peak. All isolates expressing high levels of MID had 1, 2, or 3 triplets of G's in their poly(G) tracts, while strains not expressing MID had 4, 7, 8, or 10 G's in their poly(G) tracts or point mutations causing a putative preterminated translation. Northern blot analysis revealed that the mid gene was regulated at the transcriptional level. Experiments with nonclumping variants of M. catarrhalis proved that bacteria lost their MID expression by removing a G in their poly(G) tracts. Moraxella strains isolated from the nasopharynx or from blood and sputum specimens expressed MID at approximately the same frequency. In addition, no variation was observed between strains of different geographical origins (Australia, Europe, Japan, or the United States). MID and the mid gene were found solely in M. catarrhalis, whereas related Neisseria and Moraxella species did not express MID. Taken together, MID appears to be a conserved protein that can be found in essentially all M. catarrhalis strains. Furthermore, MID is governed by poly(G) tracts when bacteria undergo phase variation.