gebhart/patrepeval huggingface dataset:
Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange (2018)

The success of targeted covalent inhibitors in the global pharmaceutical industry has led to a resurgence of covalent drug discovery. However, covalent inhibitor design for flexible binding sites remains a difficult task due to a lack of methodological development. Here, we compared covalent docking to empirical electrophile screening against the highly dynamic target K-Ras<sup>G12C</sup>. While the overall hit rate of both methods was comparable, we were able to rapidly progress a docking hit to a potent irreversible covalent binder that modifies the inactive, GDP-bound state of K-Ras<sup>G12C</sup>. Hydrogen-deuterium exchange mass spectrometry was used to probe the protein dynamics of compound binding to the switch-II pocket and subsequent destabilization of the nucleotide-binding region. SOS-mediated nucleotide exchange assays showed that, contrary to prior switch-II pocket inhibitors, these new compounds appear to accelerate nucleotide exchange. This study highlights the efficiency of covalent docking as a tool for the discovery of chemically novel hits against challenging targets.
From Passion to Cynism in Peter Shaffer's Equus (2016)

English The present paper aims to offer an overview of Dixon’s From Passions to Emotions: The Creation of a Secular Psychological Category and Pugmire’s Sound Sentiments: Integrity in the Emotions, emphasizing the historical evolution and descent of emotions into abstract secularization and the nature of emotional vices, respectively. The theoretical background provided will serve as methodological framework for the second part of this paper that will revolve around Peter Shaffer’s play Equus (1973) and the passions and affections, as well as disillusionment, cynicism and resignation displayed by the two main characters: a young boy named Alan Strang and his middleaged psychiatrist Martin Dysart. Francais Le present document vise a offrir une synthese de « From Passions to Emotions: The Creation of a Secular Psychological Category », ecrit par Dixon et « Sound Sentiments: Integrity in the Emotions » ecrit par Pugmire, en soulignant l’evolution historique et l’origine des emotions dans une secularisation abstraite et la nature des vices emotionnels. Le contexte theorique prevu servira comme cadre methodologique de la seconde partie de ce document qui tournera autour de la piece de theâtre « Equus » ecrite par Peter Shaffer (1973) et les passions et affections, aussi bien que desillusion, cynisme et resignation affiches par les deux protagonistes : un jeun garcon nomme Alan Strang et son psychiatre d’un âge moyen, Martin Dysart.
Rapid combined <i>T</i><sub>1</sub> and <i>T</i><sub>2</sub> mapping using gradient recalled acquisition in the steady state (2003)

A novel, fully 3D, high-resolution T(1) and T(2) relaxation time mapping method is presented. The method is based on steady-state imaging with T(1) and T(2) information derived from either spoiling or fully refocusing the transverse magnetization following each excitation pulse. T(1) is extracted from a pair of spoiled gradient recalled echo (SPGR) images acquired at optimized flip angles. This T(1) information is combined with two refocused steady-state free precession (SSFP) images to determine T(2). T(1) and T(2) accuracy was evaluated against inversion recovery (IR) and spin-echo (SE) results, respectively. Error within the T(1) and T(2) maps, determined from both phantom and in vivo measurements, is approximately 7% for T(1) between 300 and 2000 ms and 7% for T(2) between 30 and 150 ms. The efficiency of the method, defined as the signal-to-noise ratio (SNR) of the final map per voxel volume per square root scan time, was evaluated against alternative mapping methods. With an efficiency of three times that of multipoint IR and three times that of multiecho SE, our combined approach represents the most efficient of those examined. Acquisition time for a whole brain T(1) map (25 x 25 x 10 cm) is less than 8 min with 1 mm(3) isotropic voxels. An additional 7 min is required for an identically sized T(2) map and postprocessing time is less than 1 min on a 1 GHz PIII PC. The method therefore permits real-time clinical acquisition and display of whole brain T(1) and T(2) maps for the first time.
A Novel Improved Variable Step-Size Incremental-Resistance MPPT Method for PV Systems (2010)

Maximum power point (MPP) tracking (MPPT) techniques are widely applied in photovoltaic (PV) systems to make PV array generate peak power which depends on solar irradiation. Among all the MPPT strategies, the incremental-conductance (INC) algorithm is widely employed due to easy implementation and high tracking accuracy. In this paper, a novel variable step-size incremental-resistance MPPT algorithm is introduced, which not only has the merits of INC but also automatically adjusts the step size to track the PV array MPP. Compared with the variable step-size INC method, the proposed scheme can greatly improve the MPPT response speed and accuracy at steady state simultaneously. Moreover, it is more suitable for practical operating conditions due to a wider operating range. This paper provides the theoretical analysis and the design principle of the proposed MPPT strategy. Simulation and experimental results verify its feasibility.
Tailoring the Surface of Silicon Nanoparticles for Enhanced Chemical and Electrochemical Stability for Li-Ion Batteries (2019)

Organic monolayers of epoxy-containing oligo(ethylene oxide)s were grafted to the surface of silicon nanoparticles via a hydrosilylation reaction. The surface functional groups suppressed the chemical and electrochemical reactivity of the as-grown and lithiated silicon nanoparticles with high material utilization. A robust Si/electrolyte interphase was formed with the participation of the grafted organic groups with facilitated Li+ transfer and was further enforced by electrode integrity via the epoxy/poly(acrylic acid) (PAA) binder reaction. The improved cycling stability and post-test analysis indicate that surface functionalization on the Si particle level is a feasible approach to enabling a Si anode in high-energy-density lithium-ion batteries.
Nanostructured CMOS wireless ultra-wideband label-free DNA analysis SoC (2012)

A 0.13-micron CMOS fully integrated 48-channel UWB label-free DNA analysis SoC is demonstrated in prostate cancer screening. The 3mm×3mm die includes 578 nanostructured DNA sensors, 48 pH sensors, and 48 temperature sensors and reuses key circuits for cyclic voltammetry, amperometry and temperature regulation.
Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview (2018)

Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans <i>in vitro</i> and <i>in vivo</i>.
High optical anisotropy in thin films of polyfluorene and its affect on the outcoupling of light in typical polymer light emitting diode structures (2002)

The anisotropic optical response of thin films of the conjugated polymer PF2/6am5 (polyfluorene) is investigated using spectroscopic ellipsometry. The influence of the highly dispersive and anisotropic character of refractive index, found in this work for the π–π* transition region, on the outcoupling efficiency of light emitting devices is calculated by applying a simple ray optics model. Polymer light emitting diodes are constructed using PF2/6am4 and PtOEP doped PF2/6am4 (0.5%, 2%, and 4%) as an active layer and their external quantum efficiency (EQE) measured. Electroluminescence spectra of the doped devices are shifted to red wavelengths. The effect of transferring the emission away from high dispersive wavelengths on the outcoupling efficiency is determined and internal quantum efficiency (IQE) values for all devises are calculated. It is shown, that the increase in IQE by doping with PtOEP of up to 80% is completely accountable to the higher photoluminescence quantum yield of the dye. Accounting properly for the anisotropic optic properties of thin spun cast polymer films shows that the simple 2n2 relationship between IQE and EQE yields a large overestimate of the former.
Over de muren kijken van je eigen organisatie (2021)

Evelyn Finnema hield op 5 oktober jongstleden haar oratie als hoogleraar Verplegingswetenschap en Onderwijs bij het Universitair Medisch Centrum Groningen (UMCG). En op 1 mei volgde zij Bianca Buurman op als Chief Nursing Officer (CNO) bij het ministerie van VWS. Hoog tijd voor een interview met Evelyn Finnema, die ook nog lector is bij de Hanzehogeschool in Groningen en NHL Stenden Hogeschool in Leeuwarden. We spraken haar over haar oratie en haar veelzijdige werk in de verpleegkunde en het verpleegkundeonderwijs.
Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer (2016)

Serum levels of C16:1, C18:2, C20:4, and C22:6 could be diagnostic indicators of early-stage CRC patients.
Sequence-Tagged-Site (STS) Markers of Arbitrary Genes: Development, Characterization and Analysis of Linkage in Black Spruce (1998)

Sequence-tagged-site (STS) markers of arbitrary genes were investigated in black spruce [Picea mariana (Mill.) B.S.P.]. Thirty-nine pairs of PCR primers were used to screen diverse panels of haploid and diploid DNAs for variation that could be detected by standard agarose gel electrophoresis without further manipulation of amplification products. Codominant length polymorphisms were revealed at 15 loci. Three of these loci also had null amplification alleles as did 3 other loci that had no apparent product-length variation. Dominant length polymorphisms were observed at 2 other loci. Alleles of codominant markers differed in size by as little as 1 bp to as much as an estimated 175 bp with nearly all insertions/deletions found in noncoding regions. Polymorphisms at 3 loci involved large (33 bp to at least 114 bp) direct repeats and similar repeats were found in 7 of 51 cDNAs sequenced. Allelic segregation was in accordance with Mendelian inheritance and linkage was detected for 5 of 63 pairwise combinations of loci tested. Codominant STS markers of 12 loci revealed an average heterozygosity of 0.26 and an average of 2.8 alleles in a range-wide sample of 22 trees.
Ultrafiltration and Diafiltration (2009)

“Biotech Processes” discusses fundamental information about biotechnology manufacturing useful to practitioners in validation and compliance. Reader comments, questions, and suggestions are needed to make this column a useful resource for daily work applications. The key objective for this column: useful information. Contact column coordinator David Fetterolf at dfetterolf@biotechlogic.com or journal coordinating editor Susan Haigney at shaigney@advanstar.com with comments, questions, or suggestions for future discussion topics.
Prevalence of low back pain, seeking medical care, and lost time due to low back pain among manual material handling workers in the United States (2019)

LBP, the least severe low back health effect studied, had the highest prevalence (25%) and lost time due to LBP, the most severe low back health effect studied, had the lowest prevalence (10%) among nearly 2000 US manual material handling workers. There was a significant site or regional influence in prevalence rates for seeking medical care and lost time due to LBP.
Use of a Trephine to Extract Broken Femoral Stems (2008)

structures and of repeatedi nsertion attempts becoming necessary. While the amount of thrust maybeimportant in the deflection of wires, these two types of wirew ere deflected by similara mounts despite the fact that different thrusts were probablyrequired for their insertion.
A 1024-QAM capable WLAN receiver with −56.3 dB image rejection ratio using self-calibration technique (2017)

This paper presents a 1024-QAM OFDM signal capable WLAN receiver in 65 nm CMOS technology. Thermal noise-based IQ frequency-independent mismatch correction and IQ frequency-dependent mismatch correction with baseband loopback are proposed for the self-calibration in the receiver. By using proposed calibration method, neither received external signal nor RF loopback are necessary and the residual IQ mismatch of TXBB can be removed. The measured image rejection ratio of the self-calibration is −56.3 dB. The receiver achieves the extremely low EVM of −37.1 dB even with wide channel bandwidth of 80 MHz and has the ability to receive the 1024-QAM signal. The result indicates that the receiver is extendable for the 802.11ax compliant receiver that supports a higher density modulation scheme of MIMO.
The efficacy of zinc for treatment of chronic prostatitis. (2013)

zinc supplements may benefit in management of patients with chronic prostatitis NIH-IIIA. It can be attributable to anti-bacterial and immuno-modulatory functions of organic zinc in the body.
<i>In vitro</i> induction of CD25<sup>+</sup> CD4<sup>+</sup> regulatory T cells by the neuropeptide alpha‐melanocyte stimulating hormone (α‐MSH) (2001)

Recently, we have found that the neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) not only suppresses IFN-gamma production, but also induces TGF-beta1 production by activated effector T cells. These alpha-MSH- treated effector T cells function as regulatory T cells in that they suppress IFN-gamma production and hypersensitivity mediated by other effector T cells. Experimental autoimmune uveoretinitis (EAU) was suppressed in its severity and incidence in mice that were injected with primed T cells activated in vitro by APC and antigen in the presence of alpha-MSH. Moreover, it appeared that alpha-MSH had converted a population of effector T cells polarized to mediate hypersensitivity into a population of T cells that now mediated immunoregulation. To characterize these alpha-MSH- treated T cells, primed T cells were TCR-stimulated in the presence of alpha-MSH in vitro and their lymphokine profile was examined. Such effector T cells displayed enhanced levels of TGF-beta1 production and no IFN-gamma or IL-10, with IL-4 levels remaining unchanged in comparison with inactivated T cells. In addition, if soluble TGF-beta receptor II was added to cocultures of alpha-MSH-treated T cells and activated Th1 cells, the alpha-MSH-treated T cells could not suppress IFN-gamma production by the Th1 cells. These results suggest that alpha-MSH induces T cells with a regulatory lymphokine pattern, and that through their production of TGF-beta1 these cells suppress other effector T cells. Examination of the alpha-MSH-treated T cells showed that alpha-MSH did not alter the phosphorylation of CD3 molecules following TCR engagement. Primed T cells express the melanocortin 5 receptor (MC5r), a receptor that is linked to an intracellular signalling pathway shared by other cytokine receptors. Blocking the receptor with antibody prevented alpha-MSH from suppressing IFN-gamma production by the activated regulatory T cells, suggesting that alpha-MSH immunoregulation is through the MC5r on primed T cells. Surface staining and cell sorting of the alpha-MSH- treated primed T cells showed that the regulatory T cells are CD25+ CD4+ T cells. From these results we find that alpha-MSH can mediate the induction of CD25+ CD4+ regulatory T cells. These regulatory T cells require specific antigen for activation, but through non-specific TGF-beta1-mediated mechanisms they can suppress other effector T cells.
DNA-Enabled Self-Assembly of Plasmonic Nanoclusters (2011)

DNA nanotechnology provides a versatile foundation for the chemical assembly of nanostructures. Plasmonic nanoparticle assemblies are of particular interest because they can be tailored to exhibit a broad range of electromagnetic phenomena. In this Letter, we report the assembly of DNA-functionalized nanoparticles into heteropentamer clusters, which consist of a smaller gold sphere surrounded by a ring of four larger spheres. Magnetic and Fano-like resonances are observed in individual clusters. The DNA plays a dual role: it selectively assembles the clusters in solution and functions as an insulating spacer between the conductive nanoparticles. These particle assemblies can be generalized to a new class of DNA-enabled plasmonic heterostructures that comprise various active and passive materials and other forms of DNA scaffolding.
Managing Objects in a Relational Framework (1989)

Abstract : The papers collected in this report present ongoing research within the KBMS and PENGUIN projects at Stanford's Computer Science Department and Section on Medical Informatics. They have been issued together in response to a large number of requests. The work presents the motivations for dealing with complex objects and our implementation of the machinery necessary for creating object instances in a relational database. The object generator obtains the data and can create a variety of object configurations, as appropriate to the specific application. The knowledge needed for object generation is obtained from these sources: the structural database schema, application views applied to it, and object prototypes in the application programs. Keywords: Information science, Data bases, Medical data.
Nicotinic Modulation of [<sup>3</sup>H]Dopamine Release from Striatal Synaptosomes: Pharmacological Characterisation (1990)

Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. We have compared the effects of a number of nicotinic agonists and antagonists on a perfused synaptosome preparation preloaded with [3H]dopamine. (-)-Nicotine, acetylcholine, and the nicotinic agonists cytisine and 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), at micromolar concentrations, stimulated the release of [3H]dopamine from striatal nerve terminals. Carbamylcholine was a much weaker agonist. The actions of (-)-nicotine, cytisine, and DMPP were inhibited by low concentrations of the nicotinic antagonists dihydro-beta-erythroidine, mecamylamine, pempidine, and neosurugatoxin; alpha-bungarotoxin was without effect, and extending the time of exposure to this toxin resulted in only very modest inhibition. This pharmacology points to a specific nicotinic receptor mechanism that is clearly distinct from that at the neuromuscular junction. Atropine failed to antagonise the effects of acetylcholine and carbamylcholine, suggesting that no muscarinic component is involved. The nicotinic receptor ligands (-)-[3H]nicotine and 125I-alpha-bungarotoxin bound to specific sites enriched in the synaptosome preparation. Drugs tested on the perfused synaptosomes were examined for their ability to interact with these two ligand binding sites in brain membranes. The differential sensitivity to the neurotoxins alpha-bungarotoxin and neosurugatoxin of the 125I-alpha-bungarotoxin and (-)-[3H]nicotine binding sites, respectively, leads to a tentative correlation of the (-)-[3H]nicotine site with the presynaptic nicotinic receptor on striatal nerve terminals.
Efficient Integrated Light-Delivery System Design for HAMR: Maximal Optical Coupling for Transducer and Nanowaveguide (2015)

Light-delivery system for heat-assisted magnetic recording consists of laser, waveguide, and plasmonic near-field transducer (NFT). The overall efficiency of light-delivery system is determined by the efficiency of optical power transfer from waveguide to media via the plasmonic NFT and coupling of light from laser to waveguide. In this paper, we present an overall efficiency optimization of the light-delivery system, including the waveguide-NFT-media coupling efficiency by improving the waveguide mode-plasmon mode conversion and waveguide-media-stack impedance matching and laser-to-waveguide coupling efficiency using multi-layer graded refractive-index (GRIN) cladding layer. We show that a high refractive-index waveguide improves waveguide mode-to-asymmetric plasmon mode conversion and also improves characteristic impedance matching with the media stack resulting in a maximal optical power transfer efficiency of 11.5% between the waveguide and the media via a taper-based NFT. The multi-layer GRIN cladding structure acts as a collimating lens with a high numerical aperture, which can achieve laser-to-waveguide coupling efficiency of 90% in our numerical example. Therefore, the overall optimization shows that the efficiency of light-delivery system can reach 9%-10%.
Design Methodology for a Very High Frequency Resonant Boost Converter (2012)

This paper introduces a design methodology for a resonant boost converter topology that is suitable for operation at very high frequencies. The topology we examine features a low parts count and fast transient response, but suffers from higher device stresses compared to other topologies that use a larger number of passive components. A numerical design procedure is developed for this topology that does not rely on time-domain simulation sweeps across parameters. This allows the optimal converter design to be found for a particular main semiconductor switch. If an integrated power process is used where the designer has control over layout of the semiconductor switch, the optimal combination of converter design and semiconductor layout can be found. To validate the proposed converter topology and design approach, a 75-MHz prototype converter is designed and experimentally demonstrated. The performance of the prototype closely matches that predicted by the design procedure, and the converter achieves good efficiency over a wide input voltage range.
Xenófobos en nombre del Estado social: discriminaciones en Francia (2013)

Puesto que las finanzas publicas se hallan en una mala situacion, se debe proteger el modelo social persiguiendo a los defraudadores, pero asimismo a los extranjeros. Este razonamiento martilleado por numerosos responsables politicos europeos ha ganado en legitimidad, incluso dentro de la Administracion francesa.
Lymphocytes and low‐frequency electromagnetic fields (1992)

Human lymphocytes have been used by several researchers to investigate the biological effect of electromagnetic fields (EMF). EMF modulate the response by lymphocytes to lectin stimulation. The size and direction of the effect depends both on the lymphocyte physiology and on the physical parameters characterizing the EMF. Lymphocytes have also been used to investigate the genotoxicity of EMF exposure.
Holographic fabrication of multiple layers of grating inside soda–lime glass with femtosecond laser pulses (2002)

Gratings have been holographically fabricated inside soda–lime glass by two-beam interference of a single 130 fs laser pulse at a wavelength of 800 nm. Because the grating was localized in the focal volume and the depth at which the grating was formed can be controlled by translation of the sample, multiple layers of grating can be fabricated. As an example, three layers of grating have been recorded at depths of ∼200, ∼400, and ∼600 μm, respectively. These gratings can be read by either of the two recording beams with reduced energy, which demonstrates their potential applications in integrated optics and optical storage.