gebhart/patrepeval huggingface dataset:
Biophysical mechanism-mediated time-dependent effect on sperm of human and monkey vas implanted polyelectrolyte contraceptive (2007)

The findings provide a means of causing such changes in the sperm that inhibit the fertilizing ability before the nucleus is affected. Therefore achieving non-obstructive vas-based contraception, without genotoxic or teratogenic effects caused by infertile sperm passing into the semen, is feasible.
ABO Blood Groups and Cardiovascular Diseases (2012)

ABO blood groups have been associated with various disease phenotypes, particularly cardiovascular diseases. Cardiovascular diseases are the most common causes of death in developed countries and their prevalence rate is rapidly growing in developing countries. There have been substantial historical associations between non-O blood group status and an increase in some cardiovascular disorders. Recent GWASs have identified ABO as a locus for thrombosis, myocardial infarction, and multiple cardiovascular risk biomarkers, refocusing attention on mechanisms and potential for clinical advances. As we highlight in this paper, more recent work is beginning to probe the molecular basis of the disease associations observed in these observational studies. Advances in our understanding of the physiologic importance of various endothelial and platelet-derived circulating glycoproteins are elucidating the mechanisms through which the ABO blood group may determine overall cardiovascular disease risk. The role of blood group antigens in the pathogenesis of various cardiovascular disorders remains a fascinating subject with potential to lead to novel therapeutics and prognostics and to reduce the global burden of cardiovascular diseases.
Stereographic Digital Cinema: Production and Exhibition Techniques in 2012 (2012)

The growth in digital, stereographic motion pictures has been surprising and strong, providing a new revenue generator for the industry. After a sluggish start for the digital cinema industry, 3-D movies have become the primary driver of digital cinema adoption. Those experienced in digital stereographic techniques are clamoring for more tools and capabilities to support their creative visions. Meanwhile, the large industry of movie production workers is clamoring for information on the basic methods of creating and presenting stereographic movies. This paper presents the techniques and tradeoffs in employing 3-D camera capture, 3-D computer generated imagery, and 2-D-to-3-D conversion in developing stereographic images. It further reviews the current status and future possibilities for 3-D viewing systems in the exhibition cinemas.
A Randomized Comparison of Verres Needle and Direct Trocar Insertion for Laparoscopy (1994)

Two hundred and fifty-two women scheduled to undergo laparoscopy were randomly assigned to a Verres needle or direct insertion group. The groups were similar with respect to incidence of obesity, prior surgical treatment, indication for operation and level of training of the surgeon performing the procedure. There were no major complications associated with either technique. Minor complications (preperitoneal insufflation, failed entry or more than three attempts necessary to enter the peritoneal cavity with the trocar) were significantly more frequent (p < 0.05) in the Verres needle technique group. One hundred and thirteen of these patients underwent sterilization procedures. The mean times for performance of the laparoscopic procedure using the direct insertion and Verres needle techniques was 15.3 and 19.6 minutes, respectively. The time saved using the direct insertion technique is explained by a significant (p < 0.01) reduction in the mean laparoscope insertion time, which was 2.2 minutes and 5.9 minutes for the direct insertion and Verres needle techniques, respectively. We prefer the direct insertion technique for trocar placement because it has fewer minor complications and requires less operating time.
N,P-Codoped Meso-/Microporous Carbon Derived from Biomass Materials via a Dual-Activation Strategy as High-Performance Electrodes for Deionization Capacitors (2017)

Nitrogen and phosphorus codoped meso-/microporous carbon derived from biomass materials has been designed and successfully fabricated as high-performance electrodes for deionization capacitors. The obtained materials were prepared by the pyrolysis of pomelo peel via a dual-activation strategy by using NH4H2PO4 and KHCO3. It is interesting that the as prepared nitrogen and phosphorus codoped meso-/microporous carbon possesses a high specific surface area of 2726 m2 g–1 with high percentage of mesopores of 52%. It has been demonstrated that the obtained electrode shows high specific capacitance, low inner resistance and good wettability. Consequently, the obtained electrode exhibits good deionization performance in a 300–1000 mg L–1 NaCl solution at 1.0–1.4 V with a flow rate of 20–60 mL min–1. The electrode reveals an ultrahigh deionization capacity of 20.78 mg g–1 at 1.4 V in a 1000 mg L–1 NaCl solution. The regeneration performance of the obtained electrode is good. The good performance is ascribed to the high specific surface area, superior micro-/mesoporous structure, and N,P-codoping. Hence, the nitrogen and phosphorus codoped meso-/microporous carbon should be a promising candidate as electrode material for deionization capacitors. The present work paves a way for the development of multiheteroatom codoped meso-/microporous carbon materials for electrochemical applications.
Molecular and Epidemiologic Trends of Caliciviruses Associated with Outbreaks of Acute Gastroenteritis in the United States, 2000–2004 (2006)

Between July 2000 and June 2004, fecal specimens from 270 outbreaks of acute gastroenteritis were sent to the Centers for Disease Control and Prevention by local or state health departments for calicivirus testing. Of the 226 outbreaks that met the criteria for inclusion in the present study, caliciviruses were detected in 184 (81%) by reverse-transcription polymerase chain reaction and nucleotide sequencing. Nursing homes, retirement centers, and hospitals were the most frequently reported settings, and person-to-person contact was the most common mode of transmission, followed by foodborne spread. Overall, genogroup II norovirus (NoV) strains were the most abundant (79%), followed by genogroup I NoV strains (19%) and sapovirus (2%). Nucleotide-sequence analysis indicated a great diversity of NoV strains and implicated the emergence of one particular sequence variant in outbreaks occurring between July 2002 and June 2003. The public health impact of caliciviruses will not be fully appreciated, nor will interventions be completely evaluated, until methods to detect these viruses are more routinely used.
Using Molecular Markers to Characterize Productivity in Chinese Hamster Ovary Cell Lines (2013)

Selection of high producing cell lines to produce maximum product concentration is a challenging and time consuming task for the biopharmaceutical industry. The identification of early markers to predict high productivity will significantly reduce the time required for new cell line development. This study identifies candidate determinants of high productivity by profiling the molecular and morphological characteristics of a panel of six Chinese Hamster Ovary (CHO) stable cell lines with varying recombinant monoclonal antibody productivity levels ranging between 2 and 50 pg/cell/day. We examined the correlation between molecular parameters and specific productivity (qp ) throughout the growth phase of batch cultures. Results were statistically analyzed using Pearson correlation coefficient. Our study revealed that, overall, heavy chain (HC) mRNA had the strongest association with qp followed by light chain (LC) mRNA, HC intracellular polypeptides, and intracellular antibodies. A significant correlation was also obtained between qp and the following molecular markers: growth rate, biomass, endoplasmic reticulum, and LC polypeptides. However, in these cases, the correlation was not observed at all-time points throughout the growth phase. The repeated sampling throughout culture duration had enabled more accurate predictions of productivity in comparison to performing a single-point measurement. Since the correlation varied from day to day during batch cultivation, single-point measurement was of limited use in making a reliable prediction.
A survey of snake-inspired robot designs (2009)

Body undulation used by snakes and the physical architecture of a snake body may offer significant benefits over typical legged or wheeled locomotion designs in certain types of scenarios. A large number of research groups have developed snake-inspired robots to exploit these benefits. The purpose of this review is to report different types of snake-inspired robot designs and categorize them based on their main characteristics. For each category, we discuss their relative advantages and disadvantages. This review will assist in familiarizing a newcomer to the field with the existing designs and their distinguishing features. We hope that by studying existing robots, future designers will be able to create new designs by adopting features from successful robots. The review also summarizes the design challenges associated with the further advancement of the field and deploying snake-inspired robots in practice.
Comparison of tetrachloromethane sorption to an alkylammonium-clay and an alkyldiammonium-clay (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of tetrachloromethane sorption to an alkylammonium-clay and an alkyldiammonium-clayJames A. Smith and Peter R. JaffeCite this: Environ. Sci. Technol. 1991, 25, 12, 2054–2058Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://doi.org/10.1021/es00024a010RIGHTS & PERMISSIONSArticle Views169Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (647 KB) Get e-Alerts Get e-Alerts
Antibody Production and In Vitro Behavior of CD27-Defined B-Cell Subsets: Persistent Hepatitis C Virus Infection Changes the Rules (2006)

There is growing interest in the tendency of B cells to change their functional program in response to overwhelming antigen loading, perhaps by regulating specific parameters, such as efficiency of activation, proliferation rate, differentiation to antibody-secreting cells (ASC), and rate of cell death in culture. We show that individuals persistently infected with hepatitis C virus (HCV) carry high levels of circulating immunoglobulin G (IgG) and IgG-secreting cells (IgG-ASC). Thus, generalized polyclonal activation of B-cell functions may be supposed. While IgGs include virus-related and unrelated antibodies, IgG-ASC do not include HCV-specific plasma cells. Despite signs of widespread activation, B cells do not accumulate and memory B cells seem to be reduced in the blood of HCV-infected individuals. This apparent discrepancy may reflect the unconventional activation kinetics and functional responsiveness of the CD27+ B-cell subset in vitro. Following stimulation with T-cell-derived signals in the absence of B-cell receptor (BCR) engagement, CD27+ B cells do not expand but rapidly differentiate to secrete Ig and then undergo apoptosis. We propose that their enhanced sensitivity to BCR-independent noncognate T-cell help maintains a constant level of nonspecific serum antibodies and ASC and serves as a backup mechanism of feedback inhibition to prevent exaggerated B-cell responses that could be the cause of significant immunopathology.
10 Gbit/s transmission over 1500 km with semiconductoroptical amplifiers (1998)

The authors experimentally demonstrate, in a fibre-loop setup, 10 Gbit/s return-to-zero propagation at 1.3 µm over more than 1500 km in a standard fibre using an optimised in-line semiconductor optical amplifier. System margins have been determined.
Creation and management of versions in multiversion data warehouse (2004)

A data warehouse (DW) provides an information for analytical processing, decision making, and data mining tools. On the one hand, the structure and content of a data warehouse reflects a real world, i.e. data stored in a DW come from real production systems. On the other hand, a DW and its tools may be used for predicting trends and simulating a virtual business scenarios. This activity is often called the what-if analysis. Traditional DW systems have static structure of their schemas and relationships between data, and therefore they are not able to support any dynamics in their structure and content. For these purposes, multiversion data warehouses seem to be very promising. In this paper we present a concept and an ongoing implementation of a multiversion data warehouse that is capable of handling changes in the structure of its schema as well as simulating alternative business scenarios.
Molecular characterization of Fusarium isolates from Ethiopia (2006)

The taxonomy of Fusarium species has been controversial. The controversy surrounding the morphology-based classification, as well as the limitations and advantages of the various tools used to circumvent this problem are discussed as an introduction to the research presented in this thesis. Emphasis in this case was on the F. oxysporum species complex. The body of the research focuses on Fusarium species in Ethiopian agriculture about which little has been published. Results from this study suggest that F. oxysporum and F. solani are the two species most commonly isolated from agricultural soils and plant tissues from Ethiopia. The Ethiopian F. solani isolates were further characterized using AFLPs which showed that these isolates group into two separate clusters. Additional characterization using EF-1á sequence analyses showed that all these isolates belong to one of the three clades previously designated for the F. solani-Nectria haematococca species complex. Nine SSR markers were developed for studying the F. oxysporum complex. These markers are highly polymorphic and should be useful for many different population genetic studies of the F. oxysporum species complex. Ethiopian F. oxysporum isolates, and F. oxysporum isolates obtained from other fungal collections, were characterized using AFLPs, SSRs and DNA sequence analyses. These studies resolved the isolates into three concordant groups that corresponded to the three clades of F. oxysporum previously designated for this species complex. Most of the Ethiopian isolates grouped in one of these three clades. This and the high degree of AFLP- and SSR-based genetic similarity observed among the Ethiopian isolates suggested that these isolates are largely clonal. In addition, a PCR-based diagnostic was developed to allow for the accurate differentiation between F. oxysporum and F. redolens which has proved to be difficult using morphological characters. The studies presented in this thesis contribute to a better understanding of Fusarium species commonly found in Ethiopia. Clearly, there is much that will still need to be done. The research presented in this thesis establishes a foundation for other studies and also provides a stimulus for further studies of these important fungi in Ethiopia. Copyright 2006, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. Please cite as follows: Bogale, MA 2006, Molecular characterization of Fusarium isolates from Ethiopia, PhD thesis, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-11072006-172206 / > D87/ag
From bench to bedside: the growing use of translational research in cancer medicine. (2010)

Cancer is responsible for one in eight deaths worldwide, with more than twelve million new cases diagnosed yearly. A large percentage of patients die after developing cancer despite aggressive treatment, indicating a need for new approaches to cancer therapy. The push for development of novel diagnostic and therapeutic agents has allowed translational cancer research to flourish. Genomic and proteomic technologies have generated an enormous amount of information critical to expanding our understanding of cancer biology. New research on the differences between normal and malignant cell biology has paved the way for the development of drugs targeted to specific biological molecules, potentially increasing antitumor efficacy while minimizing the toxicity to the patient that is seen with conventional therapeutics. Current targets in include regulators of cell cycle, angiogenesis, apoptosis, DNA repair, and growth factors and their receptors. Collaboration among researchers, clinicians, and pharmaceutical companies is vital to conducting clinical trials to translate laboratory findings into clinically applicable therapeutics. In this review, we discuss current therapeutic approaches and present an introduction to a wide range of topics undergoing investigation in an effort to highlight the importance of translational research in the development of clinically relevant therapeutic strategies.
Epithelialization in Wound Healing: A Comprehensive Review (2014)

<b>Significance:</b> Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization. This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing. <b>Recent Advances:</b> Discoveries in epidermal stem cells, keratinocyte immune function, and the role of the epidermis as an independent neuroendocrine organ will be reviewed. Novel mechanisms of gene expression regulation important for re-epithelialization, including microRNAs and histone modifications, will also be discussed. <b>Critical Issues:</b> Epithelialization is an essential component of wound healing used as a defining parameter of a successful wound closure. A wound cannot be considered healed in the absence of re-epithelialization. The epithelialization process is impaired in all types of chronic wounds. <b>Future Directions:</b> A comprehensive understanding of the epithelialization process will ultimately lead to the development of novel therapeutic approaches to promote wound closure.
MiR‐21 controls <i>in situ</i> expansion of CCR6<sup>+</sup> regulatory T cells through PTEN/AKT pathway in breast cancer (2015)

Our recent evidence showed that prior expansion of CCR6(+) Foxp3(+) regulatory T cells (Tregs) was important for their dominant enrichment in tumor tissue, which was closely related to poor prognosis of breast cancer patients. However, the underlying regulation mechanism of expansion of CCR6(+) Tregs in situ remains largely unknown. In this study, we reported that miR-21 was highly expressed in CCR6(+) Tregs in tumor tissues from a murine breast cancer model. And silencing of miR-21 could significantly reduce the proliferation of CCR6(+) Tregs in vitro. Adoptive cell-transfer assay further showed that silencing of miR-21 could alter the enrichment of CCR6(+) Tregs in the tumor mass and endow effectively antitumor effect of CD8(+) T cells using a murine breast cancer model. Mechanistic evidence showed that silencing of miR-21 enhanced the expression of its target phosphatase and tensin homolog deleted on chromosome ten (PTEN) and subsequently altered the activation of Akt pathway, which was ultimately responsible for reduced proliferation activity of CCR6(+) Tregs. Finally, we further revealed that miR-21 was also highly expressed on CCR6(+) Tregs in clinical breast cancer patients. Therefore, miR-21 can act as a fine tuner in the regulation of PTEN/Akt pathway transduction in the expansion of CCR6(+) Tregs in tumor sites and provided a novel insight into the development of therapeutic strategies for promoting T-cell immunity by regulating distinct subset of Tregs through targeting specific miRNAs.
Bilingualism in the Classroom: Using Latin as an Aid to the Learning of Modern Italian (2018)

This research explores the utility of Latin as an aid to the acquisition of modern Italian. Latin is the root of the Romance languages, and consequently many words in Italian derive directly from Latin or are cognate with Latin words. Lexical connections between the languages could therefore prove useful for students learning Italian. The motivations for researching this particular area stem from the current trend of valuing subject areas in terms of their ‘utility’ to learners. Through this research I hope to show that Latin should be valued not only intrinsically, but also that it has extrinsic value as an aid to learning modern languages.
PRESENTAN DOCUMENTAL EN TRIBUTO A SALVADOR ELIZONDO (2007)

DOCUMENTAL EL EXTRANO EXPERIMENTO DEL PROFESOR ELIZONDO RECOGE TESTIMONIOS DE RECONOCIDOS ARTISTAS Y MIEMBROS DE LA COMUNIDAD CULTURAL DEL PAIS, SOBRE LA VIDA Y OBRA DEL DESTACADO ESCRITOR. DE 56 MINUTOS DE DURACION, REALIZADO POR GERARDO VILLEGAS Y PRODUCIDO POR TV UNAM, CON APOYO DE LA DIRECCION GENERAL DE TELEVISION DE LA SECRETARIA DE EDUCACION PUBLICA, SE PRESENTO RECIENTEMENTE EN LA SALA MANUEL M. PONCE DEL PALACIO DE BELLAS ARTES A UN ANO DE LA MUERTE DE ESTE PRODIGIOSO AUTOR. LA ICONOGRAFIA DEL DOCUMENTAL FUE CEDIDA EN EXCLUSIVA PARA ESTA PRODUCCION POR LA FOTOGRAFA Y ESPOSA DE ELIZONDO, PAULINA LAVISTA, Y MUESTRA ASPECTOS DESCONOCIDOS DEL AUTOR DE FARABEUF. EL EXTRANO EXPERIMENTO... ES SEMEJANTE A UN RETRATO HABLADO. REALIZADOR CONVERSA CON PERSONAJES ALLEGADOS A LA INTIMIDAD Y A LA OBRA DEL ESCRITOR, PARA ESTABLECER UN PERFIL NUEVO DEL PERSONAJE HUMANO Y LITERARIO. ESTA PRODUCCION OFRECE UN NOVEDOSO PLANTEAMIENTO DEL LENGUAJE DOCUMENTAL Y DE LAS IM GENES. PROPOSITO ES INICIAR AL PUBLICO EN LA OBRA DE UN AUTOR CAPITAL DE LA LITERATURA NACIONAL. SE PROPORCIONA LA SEMBLANZA DEL ESCRITOR. LA ESCRITORA SILVIA MOLINA SENALO QUE A UN ANO DEL FALLECIMIENTO DE SALVADOR ELIZONDO, SU NOVELA FARABEUF HA SIDO REVALORADA COMO UNA OBRA DE DIMENSION UNIVERSAL DEBIDO A LAS RECIENTES RELECTURAS A LAS QUE HA SIDO SOMETIDA POR CRITICOS Y ESPECIALISTAS EN LITERATURA. MOLINA AGREGO QUE EN REALIDAD AHORA LA TOTALIDAD DE LOS TRABAJOS DE ESTE AUTOR IMPORTAN EN LA MEDIDA QUE SU LECTURA, SIEMPRE PLACENTERA, ENTREGA A UN ESCRITOR NO SOLO PREOCUPADO POR VERDADERO FENOMENO DE LA ESCRITURA Y SUS MECANISMOS, SINO TAMBIEN POR LECTOR A QUIEN CONDUCE CON SUS TEXTOS A EXPERIMENTAR VERDADERO ACTO DE LA LECTURA. PARTICIPAR EN ESTE HOMENAJE CON LA EXHIBICION DEL DOCUMENTAL, PRECISO, ES UNA FORMA DE DIFUNDIR SU ENTRANABLE PRESENCIA LITERARIA CADA VEZ M S FUERTE ENTRE NOSOTROS. SIRVA ESTA OBRA AUDIOVISUAL PARA CONMEMORAR PRIMER ANIVERSARIO LUCTUOSO DE UN MIEMBRO FUNDAMENTAL DE LA VIDA UNIVERSITARIA Y ARTISTICA DEL PAIS, CONCLUYO LA ESCRITORA. EL EXTRANO EXPERIMENTO DEL PROFESOR ELIZONDO SE ESTRENAR  PROXIMAMENTE POR CANAL CULTURAL DE LOS UNIVERSITARIOS, QUE PUEDE SER SINTONIZADO EN CANAL 255 DE SKY, CANAL 144 DE CABLEVISION DIGITAL, Y EN M S DE 450 SISTEMAS DE TELEVISION POR CABLE DEL PAIS.