gebhart/patrepeval huggingface dataset:
Coordination Polymerization of Polar Vinyl Monomers by Single-Site Metal Catalysts (2009)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTCoordination Polymerization of Polar Vinyl Monomers by Single-Site Metal CatalystsEugene Y.-X. Chen*View Author Information Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872* To whom correspondence should be addressed. E-mail: [email protected]Cite this: Chem. Rev. 2009, 109, 11, 5157–5214Publication Date (Web):September 9, 2009Publication History Received19 January 2009Published online9 September 2009Published inissue 11 November 2009https://pubs.acs.org/doi/10.1021/cr9000258https://doi.org/10.1021/cr9000258review-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views12483Altmetric-Citations502LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Copolymerization,Monomers,Organic compounds,Polymerization Get e-Alerts
Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging (2009)

We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe2O3 nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was approximately 1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.
Non-ideal Solution Thermodynamics of Cytoplasm (2012)

Quantitative description of the non-ideal solution thermodynamics of the cytoplasm of a living mammalian cell is critically necessary in mathematical modeling of cryobiology and desiccation and other fields where the passive osmotic response of a cell plays a role. In the solution thermodynamics osmotic virial equation, the quadratic correction to the linear ideal, dilute solution theory is described by the second osmotic virial coefficient. Herein we report, for the first time, intracellular solution second osmotic virial coefficients for four cell types [TF-1 hematopoietic stem cells, human umbilical vein endothelial cells (HUVEC), porcine hepatocytes, and porcine chondrocytes] and further report second osmotic virial coefficients indistinguishable from zero (for the concentration range studied) for human hepatocytes and mouse oocytes.
Synergistic Effect of Surfactant and Salt Mixture on Interfacial Tension Reduction between Crude Oil and Water in Enhanced Oil Recovery (2013)

In the present paper the effect of salinity and different surfactants on interfacial tension (IFT) between crude oil and water has been investigated. Three different types of surfactants like anionic (sodium lauryl sulfate [SLS]), cationic (hexadecyltrimethylammonium bromide [HTAB]), and nonionic surfactants such as Tergitol 15-S-7, Tergitol 15-S-9, and Tergitol 15-S-12, respectively, have been used in this study. Improved efficiency of IFT reduction using a salt and surfactant mixture has been verified by measuring the IFT between oil and water. The synergism of salt and surfactant mixture on the reduction of IFT has been observed. A series of flooding experiments have been conducted to justify the effects of lowering interfacial tension and adsorption behavior of surfactants on additional oil recovery. It has been found that the additional oil recovery increases up to 24 % of the original oil in place (OOIP) when a surfactant and salt mixture has been used as the displacing fluid.
Static power minimization in current-mode circuits (2005)

We propose a method involving selective signal gating to minimize power dissipation in current-mode CMOS analog and multiple-valued logic (MVL) circuits employing a stack of current comparators. First, we present an approximation model for current in a current comparator circuit. Power reduction is achieved by turning off the redundant comparator circuits using a switch-architecture. Simulations are carried-out for current-mode flash ADC designs and literal generating circuits for MVL to validate the method.
Joint Link-Attribute User Identity Resolution in Online Social Networks (2012)

In the modern Web, it is common for an active person to have several proles in dierent online social networks. As new general-purpose and niche social network services arise every year, the problem of social data integration will likely remain actual in the nearest future. Discovering multiple proles of a single person across dierent social networks allows to merge all user’s contacts from dierent social services or compose more complete social graph that is helpful in many social-powered applications. In this paper we propose a new approach for user prole matching based on Conditional Random Fields that extensively combines usage of prole attributes and social linkage. It is extremely suitable for cases when prole data is poor, incomplete or hidden due to privacy settings. Evaluation on Twitter and Facebook sample datasets showed that our solution signicantly outperforms common attribute-based approach and is able to nd matches that are not discoverable by using only prole information. We also demonstrate the importance of social links for identity resolution task and show that certain proles can be matched based only on social relationships between online social networks users.
Thermal cycling-hyperthermia in combination with polyphenols, epigallocatechin gallate and chlorogenic acid, exerts synergistic anticancer effect against human pancreatic cancer PANC-1 cells (2019)

Abstract Hyperthermia (HT) has shown feasibility and potency as an anticancer therapy. Administration of HT in the chemotherapy has previously enhanced the cytotoxicity of drugs against pancreatic cancer. However, the drugs used when conducting these studies are substantially conventional chemotherapeutic agents that may cause unwanted side effects. Additionally, the thermal dosage in the treatment of cancer cells could also probably harm the healthy cells. The purpose of this work was to investigate the potential of the two natural polyphenolic compounds, epigallocatechin gallate (EGCG) and chlorogenic acid (CGA), as heat synergizers in the thermal treatment of the PANC-1 cells. Furthermore, we have introduced a novel strategy entitled the thermal cycling-hyperthermia (TC-HT) that is capable of providing a maximum synergy and minimal side effect with the anticancer compounds. Our results demonstrate that the combination of the TC-HT and the CGA or EGCG markedly exerts the anticancer effect against the PANC-1 cells, while none of the single treatment induced such changes. The synergistic activity was attributed to the cell cycle arrest at the G2/M phase and the induction of the ROS-dependent mitochondria-mediated apoptosis. These findings not only represent the first thermal synergistic study of natural compounds in the treatment of pancreatic cancer, but also highlight the potential application of the TC-HT as an alternative strategy in anticancer treatment.
Multimodal Telepresence Systems (2010)

Significant uses of immersive communication systems include support for group design activities in a -distributed context, combining human-human communication and interactivity with synthetic computer-generated content, such as three-dimensional (3-D) models or visualizations. As the demands of distributed human communication and simultaneous interaction with synthetic media continue to expand into new collaborative applications, including surgical planning, simulation training, and entertainment, we see a growing need to improve upon the state of the art of the associated technologies. To this end, we consider the demands on next-generation telepresence systems to support some of the most demanding collaborative human activities. Specifically, we explore the communications requirements for tightly coupled activities in a “shared reality” environment, where distributed users are free to move about their physical spaces, and interact with one another as if physically copresent.
Lipase-Sensitive Polymeric Triple-Layered Nanogel for “On-Demand” Drug Delivery (2012)

We report a new strategy for differential delivery of antimicrobials to bacterial infection sites with a lipase-sensitive polymeric triple-layered nanogel (TLN) as the drug carrier. The TLN was synthesized by a convenient arm-first procedure using an amphiphilic diblock copolymer, namely, monomethoxy poly(ethylene glycol)-b-poly(ε-caprolactone), to initiate the ring-opening polymerization of the difunctional monomer 3-oxapentane-1,5-diyl bis(ethylene phosphate). The hydrophobic poly(ε-caprolactone) (PCL) segments collapsed and surrounded the polyphosphoester core, forming a hydrophobic and compact molecular fence in aqueous solution which prevented antibiotic release from the polyphosphoester core prior to reaching bacterial infection sites. However, once the TLN sensed the lipase-secreting bacteria, the PCL fence of the TLN degraded to release the antibiotic. Using Staphylococcus aureus (S. aureus) as the model bacterium and vancomycin as the model antimicrobial, we demonstrated that the TLN released almost all the encapsulated vancomycin within 24 h only in the presence of S. aureus, significantly inhibiting S. aureus growth. The TLN further delivered the drug into bacteria-infected cells and efficiently released the drug to kill intracellular bacteria. This technique can be generalized to selectively deliver a variety of antibiotics for the treatment of various infections caused by lipase-secreting bacteria and thus provides a new, safe, effective, and universal approach for the treatment of extracellular and intracellular bacterial infections.
Stop-cleaved InGaAsP laser monolithically integrated with a monitoring detector (1985)

We report the monolithic fabrication of a stop-cleaved laser with a monitoring detector. Stop-cleaved, double channel planar buried heterostructure lasers with threshold currents of 57 mA have been obtained emitting at 1.3-μm wavelength. For the monitoring detector on the same substrate we have estimated a quantum efficiency of 31% from the measured responsivity of 14.4 μA/mW and the theoretical diffraction coupling efficiency.
Handbook of Pharmacokinetic/Pharmacodynamic Correlation (2019)

Pharmacokinetic-Pharmacodynamic Modeling of Reversible Drug Effects, J. Venitz. Pharmacokinetic-Pharmacodynamic Modeling of Irreversible Drug Effects, S. Ebert. Pharmacokinetic-Pharmacodynamic Modeling in Drug Development: Comments and Applications, J. Fleishaker and J. Ferry. Dose Optimization Based on Pharmacokinetic-Pharmacodynamic Modeling, G. Hochhaus and H. Derendorf. Pharmacokinetic-Pharmacodynamic Correlations of Anesthetics, V.D. Schmith and K. Muir. Pharmacokinetic-Pharmacodynamic Correlations of Analgesics, J.S. Walker. Pharmacokinetic-Pharmacodynamic Correlations of Benzodiazepines, S.K. Gupta. Pharmacokinetic-Pharmacodynamic Correlations of Anticonvulsants, M. Danhof and R. Voskuyl. Pharmacokinetic-Pharmacodynamic Correlations of Cardiovascular Drugs, R. Lalonde. Pharmacokinetic-Pharmacodynamic Correlations of Selected Vasodilators, T.-B. Tzeng and H.-L. Fung. Pharmacokinetic-Pharmacodynamic Correlations of Anticoagulants, D. Mungall and R.H. White. Pharmacokinetic-Pharmacodynamic Correlations of Antihistamines, E. Snoeck, A. Van Peer, and J. Heykants. B2-Agonists: Terbutaline, Albuterol, and Fenoterol, G. Hochhaus and H. Mollmann. Pharmacokinetic-Pharmacodynamic Correlations of Corticosteriods, H. Mollmann, S. Balbach, G. Hochhaus, J. Barth, and H. Derendorf. Pharmacokinetic-Pharmacodynamic Modeling of Antibiotics, A. Nolting and H. Derendorf. Clinical Pharmacodynamics of Anticancer Drugs, H.L. McLeod and W.E. Evans. Computer Applications in Clinical Pharmacokinetics and Pharmacodynamics, D. Mungall, J. Heissler, and M. Kaltenbach.
Sonogashira‐Type Reactions with 5‐Chloro‐1‐phenyl‐1<i>H</i>‐pyrazole‐4‐carbaldehydes: A Straightforward Approach to Pyrazolo[4,3‐<i>c</i>]pyridines (2011)

Abstract The easily obtainable 5‐chloro‐1‐phenyl‐1 H ‐pyrazole‐4‐carbaldehydes 2 were used as precursors in Sonogashira‐type cross‐coupling reactions with various alkynes to provide the corresponding 5‐alkynyl‐1 H ‐pyrazole‐4‐carbaldehydes 3 . Treatment of these with tert ‐butylamine with microwave assistance afforded the corresponding 1‐phenylpyrazolo[4,3‐ c ]pyridines 4 . The oximes 5 – derived from the aldehydes 3 – were transformed into the corresponding 1‐phenylpyrazolo[4,3‐ c ]pyridine 5‐oxides 6 through silver‐triflate‐catalysed regioselective cyclisation. Ring closure of the oximes 5 in the presence of iodine in ethanol gave the 7‐iodo‐1‐phenylpyrazolo[4,3‐ c ]pyridine 5‐oxides 7 . Detailed NMR spectroscopic investigations were undertaken with all obtained products.
Biological applications of time-of-flight mass spectrometry (1994)

Conference Article| May 01 1994 Biological applications of time-of-flight mass spectrometry Robert J. Cotter; Robert J. Cotter 1Pharmacology and Molecular Sciences, Middle Atlantic Mass Spectrometry Laboratory, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Amina S. Woods; Amina S. Woods 1Pharmacology and Molecular Sciences, Middle Atlantic Mass Spectrometry Laboratory, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Timothy J. Cornish Timothy J. Cornish 1Pharmacology and Molecular Sciences, Middle Atlantic Mass Spectrometry Laboratory, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: December 16 1993 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1994 Biochemical Society1994 Biochem Soc Trans (1994) 22 (2): 539–542. https://doi.org/10.1042/bst0220539 Article history Received: December 16 1993 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Robert J. Cotter, Amina S. Woods, Timothy J. Cornish; Biological applications of time-of-flight mass spectrometry. Biochem Soc Trans 1 May 1994; 22 (2): 539–542. doi: https://doi.org/10.1042/bst0220539 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: TOF, time of flight, MALDI, matrix-assisted laser desorption/ionization, TOF/TOF, tandem time-of-flight mass spectrometer, APP, amyloid precursor protein, PD-m.s., plasma desorption mass spectrometry This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Phospholipid class as a determinant in docosahexaenoic acid's effect on tumor cell viability. (1996)

Here we explore how incorporation of the omega-3 fatty acid docosahexaenoic acid (DHA) into murine leukemia cells (T27A) may alter membrane structure and function. When cells were cultured in DHA-supplemented medium, DHA incorporated rapidly and preferentially into phosphatidyl-ethanolamine (PE), with lesser and slower incorporation into phosphatidylcholine (PC). DHA at low concentrations preferred PE over neutral lipids, but in DHA excess accumulation in neutral lipids outstripped that of phospholipids. High DHA levels reduced cell growth in the apparent absence of lipid peroxidation. To study the importance of DHA's phospholipid class, cells were fused with lipid vesicles of either 18:0, 22:6 PE or 18:0, 22:6 PC. DHA-containing PC vesicles produced a dose-dependent decrease in cell viability, whereas PE-containing vesicles had little effect although they appeared more fusogenic. These results provoke the interesting speculation that T27A cells can safely accumulate DHA in PE, but are vulnerable if excessive DHA is incorporated into PC.
Stable and Tunable Phosphorescent Neutral Cyclometalated Au(III) Diaryl Complexes (2010)

A series of novel luminescent cyclometalated Au(III) neutral complexes of the type cis-[(N(∧)C)AuL] [N(∧)C = 2-phenylpyridine (ppy), L = 1,1'-biphenyl (1)] and cis-[(N(∧)C)AuL(2)] [N(∧)C = 2-phenylpyridine (ppy), L = C(6)H(5) (2), C(6)F(5) (3), C(6)H(4)-CF(3)-p (4), 2-C(4)H(3)S (5)]; [N(∧)C = 2-(2-thienyl)pyridine (thpy), L = C(6)H(5) (6), C(6)F(5) (7)]; [N(∧)C = 2-(5-methyl-2-thienyl)pyridine (5 m-thpy), L = C(6)F(5) (8)] were successfully synthesized. The X-ray crystal structures of all compounds except 3 have been determined. These complexes were found to show long-lived emission in solution at room temperature. The emission origins of the complexes have been tentatively assigned to be derived from triplet states predominantly bearing intraligand (IL) character with some perturbation from the metal center. Density functional theory (DFT) calculations were performed to evaluate the stability associated with the complexes and TD-DFT calculations to ascertain the nature of the excited state. Variation of the cyclometalated ligands in the complexes readily leads to the tuning of the nature of the lower energy emissive states.
A Strategy for Cultivation of Retargeted Oncolytic Herpes Simplex Viruses in Non-cancer Cells (2017)

The oncolytic herpes simplex virus (HSV) that has been approved for clinical practice and those HSVs in clinical trials are attenuated viruses, often with the neurovirulence gene γ<sub>1</sub>34.5 and additional genes deleted. One strategy to engineer nonattenuated oncolytic HSVs consists of retargeting the viral tropism to a cancer-specific receptor of choice, exemplified by HER2 (human epidermal growth factor receptor 2), which is present in breast, ovary, and other cancers, and in detargeting from the natural receptors. Because the HER2-retargeted HSVs strictly depend on this receptor for infection, the viruses employed in preclinical studies were cultivated in HER2-positive cancer cells. The production of clinical-grade viruses destined for humans should avoid the use of cancer cells. Here, we engineered the R-213 recombinant, by insertion of a 20-amino-acid (aa) short peptide (named GCN4) in the gH of R-LM113; this recombinant was retargeted to HER2 through insertion in gD of a single-chain antibody (scFv) to HER2. Next, we generated a Vero cell line expressing an artificial receptor (GCN4R) whose N terminus consists of an scFv to GCN4 and therefore is capable of interacting with GCN4 present in gH of R-213. R-213 replicated as well as R-LM113 in SK-OV-3 cells, implying that addition of the GCN4 peptide was not detrimental to gH. R-213 grew to relatively high titers in Vero-GCN4R cells, efficiently spread from cell to cell, and killed both Vero-GCN4R and SK-OV-3 cells, as expected for an oncolytic virus. Altogether, Vero-GCN4R cells represent an efficient system for cultivation of retargeted oncolytic HSVs in non-cancer cells.<b>IMPORTANCE</b> There is growing interest in viruses as oncolytic agents, which can be administered in combination with immunotherapeutic compounds, including immune checkpoint inhibitors. The oncolytic HSV approved for clinical practice and those in clinical trials are attenuated viruses. An alternative to attenuation is a cancer specificity achieved by tropism retargeting to selected cancer receptors. However, the retargeted oncolytic HSVs strictly depend on cancer receptors for infection. Here, we devised a strategy for <i>in vitro</i> cultivation of retargeted HSVs in non-cancer cells. The strategy envisions a double-retargeting approach: one retargeting is via gD to the cancer receptor, and the second retargeting is via gH to an artificial receptor expressed in Vero cells. The double-retargeted HSV uses alternatively the two receptors to infect cancer cells or producer cells. A universal non-cancer cell line for growth of clinical-grade retargeted HSVs represents a step forward in the translational phase.
Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells (2009)

Our findings demonstrate a mechanistic link between lipolysis and the amplifying pathways of GSIS in murine beta-cells, and they suggest an interaction between PKCepsilon and lipolysis. These results further highlight the therapeutic potential of PKCepsilon inhibition to enhance GSIS from the beta-cell under conditions of lipid excess.
Interaction between circadian rhythms and stress (2016)

Life on earth has adapted to the day-night cycle by evolution of internal, so-called <i>circadian</i> clocks that adjust behavior and physiology to the recurring changes in environmental conditions. In mammals, a master pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus receives environmental light information and synchronizes peripheral tissues and central non-SCN clocks to geophysical time. Regulatory systems such as the hypothalamus-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS), both being important for the regulation of stress responses, receive strong circadian input. In this review, we summarize the interaction of circadian and stress systems and the resulting physiological and pathophysiological consequences. Finally, we critically discuss the relevance of rodent stress studies for humans, addressing complications of translational approaches and offering strategies to optimize animal studies from a chronobiological perspective.
Does pH paper accurately reflect gastric pH? (1990)

The testing of gastric pH in the ICU has become the standard of care for most critically ill patients. It has been demonstrated that maintaining a gastric pH of greater than 3.5 confers protection from upper GI bleeding, while lesser pH values subject the patient to hemorrhagic risk. We compared nasogastric pH, as measured by pH electrode, to color-scaled pH paper in 16 critically ill patients hospitalized 3 to 10 days in the surgical ICU. Statistical analysis of 370 gastric specimens revealed a sensitivity of 66.7% and specificity of 94.5% when a paper pH (pH[p]) of greater than or equal to 4 was used as the therapeutic end-point. The sensitivity and specificity of the same pH(p) for clear buffered solutions were 100%. We conclude that the use of pH(p) lacks the clinical accuracy for determining the effects of therapy for the prophylaxis of stress gastritis and will lead to a significant degree of undertreatment. This lack of accuracy is not due to observer error or the quality or age of the testing paper. Our results suggest that if the measurement of gastric pH by pH(p) analysis is to be used as a guide for the prevention of stress-related hemorrhage, a more accurate method of monitoring may be warranted.