gebhart/patrepeval huggingface dataset:
Pteridine Nucleosides—New Versatile Building Blocks in Oligonucleotide Synthesis (1997)

Abstract Chemical syntheses of 1-(2-deoxy-β-D-ribofuranosyl)lumazines and isopterins as well as 8-(2-deoxy-β-D-ribofuranosyl)-4-amino-7(8H)pteridones and -isoxanthopterins have been developed to make the structural analogs of the naturally occurring 2′-deoxyribonucleosides in the pteridine series available. The corresponding phosphoramidites have been used in machine-aided solid-support syntheses leading to new types of fluorescence labeled oligonucleotides. The effects of the various fluorophors on duplex formation and as labels for enzyme reactions is demonstrated.
Planar Microstrip Yagi Antennas (1990)

Developmental class of antennas based on combination of microstrip-patch and Yagi-array concepts. Mutual coupling between microstrip elements, ordinarily considered nuisance, used to advantage. Applicable to both linearly and circularly polarized antennas. Use of fewer driven elements results in less complexity and reduced loss of power in associated transmission lines and other coupling and power-distributing circuitry. Applications include antennas on land vehicles, television receiving antennas, and conformal antennas on aircraft.
Synergistic <i>Capsicum</i>–tea mixtures with anticancer activity (2003)

We have demonstrated a synergy between a decaffeinated green tea concentrate and a vanilloid-containing Capsicum preparation obtained commercially. At a ratio of 25 parts green tea concentrate to 1 part Capsicum preparation, the resultant product exhibited efficacy in the killing of cancer cells in culture 100-times that of green tea on a weight basis. These studies were guided by assays of the putative catechin-vanilloid target protein tNOX, a cell surface growth-related enzymatic activity specific to cancer. The activity of the protein target was inhibited by the tea catechins and the Capsicum vanilloids. As with growth, the tea and Capsicum preparations evaluated were synergistic in their inhibition of the target enzymatic activity.
Fast Tracking of Cardiac Motion Using 3D-HARP (2005)

Magnetic resonance (MR) tagging is capable of accurate, noninvasive quantification of regional myocardial function. Routine clinical use, however, is hindered by cumbersome and time-consuming postprocessing procedures. We propose a fast, semiautomatic method for tracking three-dimensional (3-D) cardiac motion from a temporal sequence of short- and long-axis tagged MR images. The new method, called 3-D-HARmonic Phase (3D-HARP), extends the HARP approach, previously described for two-dimensional (2-D) tag analysis, to 3-D. A 3-D material mesh model is built to represent a collection of material points inside the left ventricle (LV) wall at a reference time. Harmonic phase, a material property that is time-invariant, is used to track the motion of the mesh through a cardiac cycle. Various motion-related functional properties of the myocardium, such as circumferential strain and left ventricular twist, are computed from the tracked mesh. The correlation analysis of 3D-HARP and FINDTAGS + Tag Strain(E) Analysis (TEA), which are well-established tag analysis techniques, shows that the regression coefficients of circumferential strain (E(CC)) and twist angle are r2 = 0.8605 and r2 = 0.8645, respectively. The total time required for tracking 3-D cardiac motion is approximately 10 min in a 9 timeframe tagged MRI dataset and has the potential to be much faster.
Polyoxazoline containing copolymers useful as emulsifiers for polymer blends (1991)

Abstract The preparation of new block and graft copolymers containing poly (2‐alkyloxazoline)s using macroinitiator methods have been investigated. Hydroxy terminated poly(2‐alkyloxazoline) oligomers can be synthesized using alkyl iodide initiators and potassium hydroxide as the terminating reagent. Polymerizations of ϵ‐caprolactone using monofunctional poly(2‐alkyloxazoline)s as macroinitiators and Sn(oct) 2 as the catalyst yield diblock copolymers of poly(2‐alkyloxazoline‐b‐ϵ‐caprolactone) with controlled molecular weights. Graft copolymers have also been prepared by first generating a poly(alkyl vinyl ether) backbone. Copolymerization of a low molar percentage of 2‐chloroethyl vinyl ether with alkyl vinyl ethers was performed using a heterogeneous cationic catalyst to yield high molecular weight random copolymers with pendent ethyl chloride groups interspersed along the chain. This pendent chlorine group, together with NaI, was used as the initiation system for 2‐alkyloxazoline grafts. Characterization of the resultant copolymers by gel permeation chromatography, intrinsic viscosity, DSC, solution and solid state 1 H and 13 C NMR is discussed. These materials are being evaluated as emulsifiers for polymer blends containing aliphatic polyamides as one component.
Herpes thymidine kinase mutants with altered catalytic efficiencies obtained by random sequence selection (1994)

We have obtained 190 active Herpes simplex virus type 1 thymidine kinase mutants by substituting a 33 nucleotide sequence with 20% degeneracy for a portion of the nucleotide sequence that encodes the putative thymidine binding site [K.M. Munir, D.C. French, D.K. Dube and L.A. Loeb (1992) J. Biol. Chem., 167, 6584-6589]. In order to classify these mutants with respect to thymidine kinase activity we determined the ability of Escherichia coli harboring these mutants to form colonies in the presence of varying concentrations of thymidine. Escherichia coli harboring one of the mutant enzymes was able to form colonies at a concentration of thymidine lower than did the wild type. It was able to phosphorylate thymidine more rapidly than the wild type both in vivo and in vitro. The increased thymidine kinase activity was manifested by (i) a 42% enhanced uptake of [methyl-3H]thymidine into E. coli, (ii) a 2.4 times higher rate of [methyl-3H]thymidine incorporation into acid-insoluble material and (iii) a 5-fold increase in the kcat of the purified enzyme compared to the wild type. Herpes thymidine kinase purified from other mutants that formed colonies at higher thymidine concentrations than that of the wild type exhibited a decrease in kcat. The kcat of one of these mutant thymidine kinases was 10(-4) of that of the wild type enzyme. This study demonstrates that a spectrum of mutant enzymes with different catalytic properties can be obtained by selection from a plasmid with random sequence substitutions and this can be done in the absence of rational protein design.
A flexible model for resource management in virtual private networks (1999)

As IP technologies providing both tremendous capacity and the ability to establish dynamic secure associations between endpoints emerge, Virtual Private Networks (VPNs) are going through dramatic growth. The number of endpoints per VPN is growing and the communication pattern between endpoints is becoming increasingly hard to forecast. Consequently, users are demanding dependable, dynamic connectivity between endpoints, with the network expected to accommodate any traffic matrix, as long as the traffic to the endpoints does not overwhelm the rates of the respective ingress and egress links. We propose a new service interface, termed a hose, to provide the appropriate performance abstraction. A hose is characterized by the aggregate traffic to and from one endpoint in the VPN to the set of other endpoints in the VPN, and by an associated performance guarantee.Hoses provide important advantages to a VPN customer: (i) flexibility to send traffic to a set of endpoints without having to specify the detailed traffic matrix, and (ii) reduction in the size of access links through multiplexing gains obtained from the natural aggregation of the flows between endpoints. As compared with the conventional point to point (or customer-pipe) model for managing QoS, hoses provide reduction in the state information a customer must maintain. On the other hand, hoses would appear to increase the complexity of the already difficult problem of resource management to support QoS. To manage network resources in the face of this increased uncertainty, we consider both conventional statistical multiplexing techniques, and a new resizing technique based on online measurements.To study these performance issues, we run trace driven simulations, using traffic derived from AT&T's voice network, and from a large corporate data network. From the customer's perspective, we find that aggregation of traffic at the hose level provides significant multiplexing gains. From the provider's perspective, we find that the statistical multiplexing and resizing techniques deal effectively with uncertainties about the traffic, providing significant gains over the conventional alternative of a mesh of statically sized customer-pipes between endpoints.
<i>Z</i>-Selective Olefin Metathesis Reactions Promoted by Tungsten Oxo Alkylidene Complexes (2011)

Addition of LiOHMT (OHMT = O-2,6-dimesitylphenoxide) to W(O)(CH-t-Bu)(PMe(2)Ph)(2)Cl(2) led to WO(CH-t-Bu)Cl(OHMT)(PMe(2)Ph) (4). Subsequent addition of Li(2,5-Me(2)C(4)H(2)N) to 4 yielded yellow W(O)(CH-t-Bu)(OHMT)(Me(2)Pyr)(PMe(2)Ph) (5). Compound 5 is a highly effective catalyst for the Z-selective coupling of selected terminal olefins (at 0.2% loading) to give product in >75% yield with >99% Z configuration. Addition of 2 equiv of B(C(6)F(5))(3) to 5 afforded a catalyst activated at the oxo ligand by B(C(6)F(5))(3). 5·B(C(6)F(5))(3) is a highly active catalyst that produces thermodynamic products (~20% Z).
Ternary Intercalation Compound of Graphite with Aluminum Fluoride and Fluorine (1981)

Abstract A ternary intercalation compound of graphite with AlF 3 and F 2 , C x F(AlF 3 ) y was prepared under fluorine atmosphere at temperatures of 20-400 °C. The typical 1st stage compound has a composition of C 6 F(AlF 3 ) 0,15 with a repeat distance of 940 pm. Rapid progress in the reaction led of the formation of graphite fluoride, (C 2 F) n . ESCA spectra indicate that the chemical bond between host graphite and intercalated fluorine has nearly covalent nature similar to that for (C 2 F) n .
A new approach to on-line turn fault detection in AC motors (2002)

Turn fault detection is based on the principal that symmetrical (unfaulted) motors powered by symmetrical multiphase voltage sources will have no negative sequence currents flowing in the leads. A turn-to-turn fault will break that symmetry and give rise to a negative sequence current which may then be used as a measure of fault severity or to initiate protective action such as a circuit breaker trip. A new way of looking at the effects of turn faults has been developed that improves sensitivity and speed while reducing the probability of misdetection, taking into account voltage balance, load or voltage variation and instrument errors. The method has been implemented on a PC and tested, in real time, on a specially prepared small motor. Reliable detection of one shorted turn out of 648 turns per phase (in a Y connected motor) was demonstrated with the fault indicator becoming fully developed in two cycles of line frequency after initiation of the fault.
Catalytic transfer hydrogenolysis of ionic liquid processed biorefinery lignin to phenolic compounds (2016)

Lignocellulosic biomass has the potential to play a significant role in the global bioeconomy for the production of renewable fuels and chemicals.
Swift (2012)

We first conduct a study using abstracted video content to measure the effects of latency on video scrubbing performance and find that even very small amounts of latency can significantly degrade navigation performance. Based on these results, we present Swift, a technique that supports real-time scrubbing of online videos by overlaying a small, low resolution copy of the video during video scrubbing, and snapping back to the high resolution video when the scrubbing is completed or paused. A second study compares the Swift technique to traditional online video players on a collection of realistic live motion videos and content-specific search tasks which finds the Swift technique reducing completion times by as much as 72% even with a relatively low latency of 500ms. Lastly, we demonstrate that the Swift technique can be easily implemented using modern HTML5 web standards.
Biological resurfacing in a canine model of hip osteoarthritis (2021)

Articular cartilage has unique load-bearing properties but has minimal capacity for intrinsic repair. Here, we used three-dimensional weaving, additive manufacturing, and autologous mesenchymal stem cells to create a tissue-engineered, bicomponent implant to restore hip function in a canine hip osteoarthritis model. This resorbable implant was specifically designed to function mechanically from the time of repair and to biologically integrate with native tissues for long-term restoration. A massive osteochondral lesion was created in the hip of skeletally mature hounds and repaired with the implant or left empty (control). Longitudinal outcome measures over 6 months demonstrated that the implant dogs returned to normal preoperative values of pain and function. Anatomical structure and functional biomechanical properties were also restored in the implanted dogs. Control animals never returned to normal and exhibited structurally deficient repair. This study provides clinically relevant evidence that the bicomponent implant may be a potential therapy for moderate hip osteoarthritis.
Influence of Pyridine–Borane on the Sintering Behavior and Properties of α‐Silicon Carbide (1991)

In the present study, α‐SiC powder is coated with pyridineborane (BH 3 ·C 5 H 5 N), a liquid molecular compound, which forms a boron carbonitride (BC 3.5 N) layer by heat treatment at 1000°C under argon. The precipitation method leads to an improved chemical homogeneity in the compacted powder resulting in enhanced densification and significant reduction in grain growth during subsequent sintering at temperatures exceeding 2070°C. Thus, small average grain sizes of d 50 = 1.3 μm and a narrow grain size distribution ( d 10 = 0.6 μm, d 90 = 2.2 μm) are detected in the liquid‐phase‐processed sample sintered at 2200°C for 0.5 h in argon. Final densities of at least 98% of theoretical could be obtained by pressureless sintering at 2100°C. These results as well as the microstructural distribution of the sintering aids in the densified samples are discussed.
Scalable propagation-based call graph construction algorithms (2000)

Propagation-based call graph construction algorithms have been studied intensively in the 199Os, and differ primarily in the number of sets that are used to approximate run-time values of expressions. In practice, algorithms such as RTA that use a single set for the whole program scale well. The scalability of algorithms such as 0-CFA that use one set per expression remains doubtful.In this paper, we investigate the design space between RTA and 0-CFA. We have implemented various novel algorithms in the context of Jax, an application extractor for Java, and shown that they all scale to a 325,000-line program. A key property of these algorithms is that they do not analyze values on the run-time stack, which makes them efficient and easy to implement. Surprisingly, for detecting unreachable methods, the inexpensive RTA algorithm does almost as well as the seemingly more powerful algorithms. However, for determining call sites with a single target, one of our new algorithms obtains the current best tradeoff between speed and precision.
P‐21: Stability and Integrability Evaluation of Organic Thin Film Transistor with Solution Processable Semiconductor (2008)

Abstract We demonstrate Organic thin film transistors (OTFTs) with solution‐processed semiconductor, triethylsilylethynyl anthradithiophene (TES‐ADT), as the active layer materials are investigated. Bottom‐gate solution‐processed TES‐ADT OTFTs possess excellent performance with mobility of 0.05 cm2V −1 s −1 , current modulation of 4×10 6 , sub‐threshold slope of 0.91 V/dec. and threshold voltage of −7.7 V on glass substrate. The reliability of device is evaluated and demonstrates good electrical performance uniformity and stability after bias stress. Particularly, the devices exhibit reversible degradation after vacuum annealing, shown it's environmental stability under air atmosphere. Moreover, the device integrability has been demonstrated with two transistors‐one capacitor (2T1C) array for display media driving such as organic light emitting diode (OLED).
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck (2012)

These observations suggest that stable interaction with Nef may induce Src-family kinase active site conformations amenable to selective inhibitor targeting.
Inhibition of [<sup>3</sup>H]Diazepam and [<sup>3</sup>H]3‐Carboethoxy‐β‐Carboline Binding by Irazepine: Evidence for Multiple “Domains” of the Benzodiazepine Receptor (1982)

The binding of [3H]diazepam and [3H]3-carboethoxy-beta-carboline was examined in rat brain synaptosomal membranes treated with irazepine, an alkylating benzodiazepine. Under incubation conditions that resulted in a 25-33% reduction in the Bmax of [3H]diazepam binding, only modest (less than 8.5%) reductions in the Bmax of [3H]3-carboethoxy-beta-carboline were observed. The differential effects of irazepine on the binding of these two compounds may be explained by the presence of multiple areas or "domains" on the benzodiazepine receptor.
<i>Mycobacterium bovis </i><scp>BCG</scp> killed by extended freeze‐drying induces an immunoregulatory profile and protects against atherosclerosis (2013)

EFD BCG has atheroprotective effects through IL-10 production and Treg expansion. These findings support a novel approach to the prevention and treatment of atherosclerosis.
Testis Tissue Explant Culture Supports Survival and Proliferation of Bovine Spermatogonial Stem Cells1 (2004)

The present study was designed to evaluate the survival and proliferation of bovine spermatogonial stem cells in an explant culture system over a 2-wk period. Explants of calf testicular parenchyma were placed on 0.45-microm pore membranes in culture and maintained for 1-2 wk. Histological examinations of fresh (t0) and cultured tissues revealed morphologically normal seminiferous tubules. Germ cell numbers/tubule increased (P < or = 0.05) during culture when compared with t0, yet germ cell differentiation was not observed. Testosterone was present in medium throughout the culture period, indicating functional Leydig cells. Sertoli, spermatogonial, and spermatogonial stem cell viability was evaluated by reverse transcription-polymerase chain reaction for cell-specific gene expression of stem cell factor, protein gene product 9.5, and glial cell line-derived neurotrophic factor family receptor-alpha1, respectively. Results demonstrated the expression of all genes at t0, 1 wk, and 2 wk of culture. Single-cell suspensions were prepared from the testicular tissues at t0 and during culture and transplanted into nude mouse testes to investigate spermatogonial stem cell viability. One month after transplantation, colonies of round bovine cells were identified in all mouse testes analyzed, indicating survival of spermatogonial stem cells. The average number of resulting colonies in recipient testes was significantly (P < or = 0.05) higher following 1 wk of culture compared with t0 and was numerically higher at 2 wk of culture compared with t0. This increase in colony numbers over time in culture indicates spermatogonial stem cell proliferation in vitro. This explant culture system appears to provide an environment that supports survival and proliferation of bovine spermatogonial stem cells.
Positional cloning of the wheat vernalization gene <i>VRN1</i> (2003)

Winter wheats require several weeks at low temperature to flower. This process, vernalization, is controlled mainly by the VRN1 gene. Using 6,190 gametes, we found VRN1 to be completely linked to MADS-box genes AP1 and AGLG1 in a 0.03-centimorgan interval flanked by genes Cysteine and Cytochrome B5. No additional genes were found between the last two genes in the 324-kb Triticum monococcum sequence or in the colinear regions in rice and sorghum. Wheat AP1 and AGLG1 genes were similar to Arabidopsis meristem identity genes AP1 and AGL2, respectively. AP1 transcription was regulated by vernalization in both apices and leaves, and the progressive increase of AP1 transcription was consistent with the progressive effect of vernalization on flowering time. Vernalization was required for AP1 transcription in apices and leaves in winter wheat but not in spring wheat. AGLG1 transcripts were detected during spike differentiation but not in vernalized apices or leaves, suggesting that AP1 acts upstream of AGLG1. No differences were detected between genotypes with different VRN1 alleles in the AP1 and AGLG1 coding regions, but three independent deletions were found in the promoter region of AP1. These results suggest that AP1 is a better candidate for VRN1 than AGLG1. The epistatic interactions between vernalization genes VRN1 and VRN2 suggested a model in which VRN2 would repress directly or indirectly the expression of AP1. A mutation in the promoter region of AP1 would result in the lack of recognition of the repressor and in a dominant spring growth habit.
Mapping corneal stiffness with compressional optical coherence elastography (2022)

Currently available clinical devices cannot provide localized maps of corneal stiffness. We present a phase-sensitive method of compressional optical coherence elastography (OCE) for mapping corneal stiffness. In situ measurements showed that the strain, ε, slightly decreased as a function of IOP and CXL significantly decreased the strain (P<0.001). The change in pressure in the eye-globe, ΔIOP, was also measured during compression. We quantified the elasticity, E, of the cornea by E=ΔIOP/ε. In contrast to the strain, there was a significant effect of the baseline IOP on the stiffness (P<0.001). After CXL, there was a ~85% increase in stiffness, which was significant (P<0.001). In addition to the whole sample CXL, partial CXL was performed where only one half of the cornea was treated. The strain in the untreated region was significantly greater (P=0.030) than the strain in the CXL region, and the elasticity was significantly greater in the CXL region (P=0.030). Next, in vivo measurements were performed in an anesthetized rabbit. The strain decreased by ~75% after CXL, which was significant (P<0.001). Partial CXL was performed on another animal, where only half the cornea was treated. The strain in the untreated region was significantly less (P<0.001) than the strain in the CXL region. Our results show the capability of compression-based OCE to measure changes in corneal biomechanical properties in 4 different scenarios (in situ traditional CXL, in situ partial CXL, in vivo traditional CXL, in vivo partial CXL).
Short-Time Optical Fiber Thermal Conductivity Sensor (1989)

Thermal conductivities of liquids have been determined by using a variation of the transient hot-wire technique. A short segment of one arm of a fiber-optic Mach-Zehnder interferometer is coated with a thin layer of gold. This gold layer is heated resistively with a 1 msec current pulse producing a temperature change of only tenths of a degree. The magnitude of this temperature change (determined by the phase change in the interferometer) can be used to calculate the thermal conductivity of the medium in which the fiber is immersed. The conventional transient hot-wire thermal conductivity technique employs a much larger temperature rise and requires numerous correction terms. Results obtained in aqueous ethylene glycol solutions are reported.