gebhart/patrepeval huggingface dataset:
Circulating Activated Platelets Reconstitute Lymphocyte Homing and Immunity in L-selectin–Deficient Mice (1998)

Peripheral lymph nodes (PLN) are critical for immunologic memory formation in response to antigens that penetrate the skin. Blood-borne lymphocytes first encounter such antigens after they home to PLN through a multi-step adhesion process that is normally initiated by L-selectin (CD62L) in high endothelial venules (HEV). Since naive T cells can not enter PLN normally in L-selectin-deficient mice, a delayed type hypersensitivity response to cutaneously applied antigen cannot be mounted. In this study, we report that the administration of activated platelets into the systemic circulation of L-selectin knockout mice restores lymphocyte trafficking to PLN, and reconstitutes T cell-mediated immunity in response to a cutaneous antigen. These effects required platelet-expressed P-selectin that allows activated platelets to transiently form a bridge between lymphocytes and HEV, thereby enabling lymphocytes to undergo subsequent beta2 integrin-dependent firm adhesion. These profound effects of platelet-mediated cell-cell interactions on lymphocyte trafficking and formation of immunologic memory may impact on a variety of autoimmune and inflammatory conditions.
Basic fibroblast growth factor modulates the mitogenic potency of the platelet-derived growth factor (PDGF) isoforms by specific upregulation of the PDGF alpha receptor in vascular smooth muscle cells. (1992)

Platelet-derived growth factor AA (PDGF AA), in contrast to PDGF AB and BB, is a poor mitogen for smooth muscle cells (SMC). However, together with basic fibroblast growth factor (bFGF) it acts synergistically on DNA synthesis of these cells. Northern blot analysis revealed that bFGF selectively increases the PDGF-receptor alpha subtype (PDGF-R alpha) mRNA level without a significant effect on the PDGF-R beta mRNA level. The amount of PDGF-R alpha protein is also selectively increased after stimulating SMC with bFGF as shown by immunoprecipitation of lysates from SMC with anti-PDGF-R alpha antibodies. The number of binding sites for 125I-PDGF AA is more than doubled after bFGF-treatment, whereas the specific binding for PDGF AB and BB increased only by approximately 30 and 20%, respectively. The increase in the number of PDGF-R alpha renders the SMC responsive for PDGF AA as demonstrated by the induction of the proto-oncogene c-fos as well as by an increased cell proliferation. The enhanced PDGF binding after bFGF treatment may in fact explain the observed synergistic behavior. These data are discussed with regard to a possible role of growth factor-induced transmodulation of receptor expression during atherogenesis.
Research roundup: August 2016 (2016)

In this section, a range of brief synopses of recently published articles that may be of interest to health visitors is presented. The aim of this roundup is to provide an overview, rather than a detailed summary, of the research papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided.
A Fast Routing Method in Multi-hop Cellular Network (2008)

This paper proposes a method of routing in multi-hop cellular network.The method fully considers the fact that multi-hop cellular network(MCN) is based on a centric base,and changes conventional distribute routing to a centralized manner.The method also develops a set of control messages that fits it.Taking advantage of centralized processing,the base station can gradually obtain the topology of the cell through information from routing process,and makes routing more efficient.Simulation results show that compared with existed methods,this method decrease the time of route discovery significantly and also improve the routing quality.
On Computing Reliable Optimal Grasping Forces (2012)

This paper presents algorithms for optimal grasping forces. The previous work reveals that contact forces with minimal sum or maximum of normal force components can be written as positive combinations of primitive contact forces, to which the corresponding primitive contact wrenches express the required resultant wrench as their positive combination with minimum coefficients in terms of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> or <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> metric. On this basis, we first propose an algorithm to compute such a set of primitive contact forces and the minimum contact forces. Moreover, considering the uncertainty in the actual friction coefficient, we develop another algorithm to determine the minimum required friction coefficient and the corresponding minimum contact forces within a given limit on their magnitude so that such contact forces are more reliable in practice. As our algorithms do not rely on any general optimization technique, they are very efficient and easy to implement. These algorithms can also be used in grasp quality evaluation and optimal grasp planning.
Accumulation of human immunodeficiency virus type 1 DNA in T cells: results of multiple infection events (1990)

Human immunodeficiency virus type 1 DNA synthesis was followed in a CD4+ line of T cells (C8166) grown in the presence or absence of a monoclonal antibody to CD4 that blocks infection By 48 h after infection, cultures grown in the presence of the antibody contained approximately 4 copies of human immunodeficiency virus type 1 DNA per cell, whereas those grown in the absence of the antibody contained approximately 80 copies of viral DNA per cell. Most of the viral DNA in cultures grown in the absence of the antibody was present in a broad smear of apparently incomplete viral sequences. In cultures grown in the presence or absence of the antibody, the 9.6-kilobase linear duplex of viral DNA appeared to undergo integration within 24 h of its appearance. These results demonstrate that T cells accumulate unintegrated human immunodeficiency virus type 1 DNA as a result of multiple virions entering cells.
Time-Frequency Domain Analysis via Pulselets for Non-contact Heart Rate Estimation from Remotely Acquired Photoplethysmograms (2016)

A novel method for remote heart rate estimation via analysis in the time-frequency domain is proposed. A photoplethysmogram (PPG) waveform is constructed via a Bayesian minimization approach with the required posterior probability obtained through an importance-weighted Monte Carlo sampling method. A pulselet (wavelet chosen for its similarities with a finger pulse oximiter PPG waveform), is used in the continuous wavelet transform to produce a map of the wavelet energy response in the time-frequency domain. This allows the heart rate frequency to be estimated at each time step, accounting for naturally occurring changes in heart rate over time which may cause error with frequency domain based methods. The frequency corresponding to the highest wavelet response at each time step is averaged across the entire time series to estimate the average heart rate. Experimental results against a data set of 30 videos show an improvement over current state-of-the-art methods.
TEMPERATURE AND STRAIN SENSITIVITY OF LONG PERIOD GRATING FIBER SENSOR: REVIEW (2015)

Long period grating fibers are special class of fibers which are produced by periodic modulation of the refractive index of the core. This perturbation leads to forward guiding mode to couple with co propagating cladding modes depending on the phase matching condition. This coupling causes the cladding modes to attenuate during propagation in the fiber and leads to dips in the attenuation bands at discrete wavelengths in the transmission spectrum. These bands are shifted when the LPG is exposed to temperature, strain, refractive index changes in surrounding environment etc. This forms the basis of LPG sensor. The properties of LPG are modified in order to achieve the required sensitivity towards any measurands as per the applications. The performance of LPG by modifying the properties of LPG is reviewed.
Calibration of Trapping Force on Cell-Size Objects From Ultrahigh-Frequency Single-Beam Acoustic Tweezer (2016)

In this paper, we report a calibration of acoustic trapping force of single-beam acoustic tweezer (SBAT) at ultrahigh frequency using micropipette aspiration. The acoustic trapping forces ( F<sub>trapping</sub>) and the trap stiffness on a 5- [Formula: see text] polystyrene microbead for a 110-MHz SBAT were measured against the known force generated from a micropipette. The trap stiffness ( k ), which represents F<sub>trapping</sub> corresponding to a displacement ( x ) of a microbead from the trap center, was measured and the results showed that a higher duty factor and excitation voltage lead to a stronger trapping force and trap stiffness for a given displacement. Since a precisely calibrated force generated from a micropipette is directly applied to the calculation of acoustic trapping force, the approach should be more flexible than those previously reported. In addition, with this method, precisely controlling the tip size of a micropipette within a few micrometers allows the possibility of calibrating the trapping force on an object of the size of a single cell. It not only helps better evaluate the trapping performance of SBAT as a tool of cell manipulation, but also helps develop SBAT as a useful tool for assessing cellular interactions.
The differentiation antigen Ly‐6E.1 is expressed in mouse metastatic tumor cell lines (1997)

We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly metastatic mouse adenocarcinoma cell line CSML-100 by differential display. The expression is specific for the metastatic cell line as the closely related, non-metastatic mouse adenocarcinoma cell line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour cell lines, exclusively metastatic ones. To date, active Ly-6A/E has only been described in lymphoid cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed.
Panama - Rural Productivity and Consolidation of the Mesoamerican Biological Corridor Project : indigenous peoples plan (2005)

The Project aims to reduce rural poverty and improve natural resource conservation and management by increasing investment for sustainable development, and improving local governance in poor rural areas. It would contribute to three priorities for the country's social and economic development: rural poverty reduction; local government strengthening; and, natural resource management, biodiversity conservation, and environmental protection. In light of indigenous populations living in and around the project area, this Indigenous Peoples Plan (IPP) takes into consideration the basic principle that biodiversity conservation alone would not succeed, unless a socio-biological focus is triggered that includes local people and communities as components of such ecosystems, where productive and administrative practices are developed towards sustainable ecosystems development in a collaborative approach. The plan thus addresses three main activities specifically targeting local indigenous populations: 1) provision of local capacity building in the management of productive processes, and services; improved methods to increase local productivity and its trade, including improved employment generation, and opportunities; and, the adequate provision of basic services.
Inhibition of Connexin Hemichannels by New Amphiphilic Aminoglycosides without Antibiotic Activity (2018)

Connexins hemichannels (HCs) from adjacent cells form gap junctional channels that mediate cell-to-cell communication. Abnormal opening of "free" undocked HCs can produce cell damage and participate in the mechanism of disorders such as cardiac infarct, stroke, deafness, skin diseases, and cataracts. Therefore, inhibitors of connexin HCs have great pharmacological potential. Antibiotic aminoglycosides (AGs) have been recently identified as connexin HC inhibitors, but their antibiotic effect is an issue for the treatment of disorders where infections do not play a role. Herein, we synthesized and tested several amphiphilic AGs without antibiotic effect for their inhibition against connexin HCs, using a newly developed cell-based bacterial growth complementation assay. Several leads with superior potency than the parent compound, kanamycin A, were identified. Unlike traditional AGs, these amphiphilic AGs are not bactericidal and are not toxic to mammalian cells, making them better than traditional AGs as HC inhibitors for clinical use and other applications.
The actinobacterial WhiB‐like (Wbl) family of transcription factors (2018)

The WhiB-like (Wbl) family of proteins are exclusively found in Actinobacteria. Wbls have been shown to play key roles in virulence and antibiotic resistance in Mycobacteria and Corynebacteria, reflecting their importance during infection by the human pathogens Mycobacterium tuberculosis, Mycobacterium leprae and Corynebacterium diphtheriae. In the antibiotic-producing Streptomyces, several Wbls have important roles in the regulation of morphological differentiation, including WhiB, a protein that controls the initiation of sporulation septation and the founding member of the Wbl family. In recent years, genome sequencing has revealed the prevalence of Wbl paralogues in species throughout the Actinobacteria. Wbl proteins are small (generally ~80-140 residues) and each contains four invariant cysteine residues that bind an O<sub>2</sub> - and NO-sensitive [4Fe-4S] cluster, raising the question as to how they can maintain distinct cellular functions within a given species. Despite their discovery over 25 years ago, the Wbl protein family has largely remained enigmatic. Here I summarise recent research in Mycobacteria, Corynebacteria and Streptomyces that sheds light on the biochemical function of Wbls as transcription factors and as potential sensors of O<sub>2</sub> and NO. I suggest that Wbl evolution has created diversity in protein-protein interactions, [4Fe-4S] cluster-sensitivity and the ability to bind DNA.
Demonstration of a Diurnal Variation in Serum Parathyroid Hormone in Primary and Secondary Hyperparathyroidism (1975)

It had been reported previously that there is a diurnal variation in serum parathyroid hormone (PTH) in normal subjects but not in patients with primary hyperparathyroidism. Studies were performed to determine whether there is a diurnal variation in serum PTH in primary or secondary hyperparathyroidism and whether the nocturnal increase in serum PTH, if present, could be prevented by induced hypercalcemia. Serum PTH and calcium were measured in five normal subjects, two patients with pseudohypoparathyroidism, and fourteen patients with primary hyperparathyroidism, twelve of whom were subsequently found to have parathyroid adenomas. In the normals, there was a mean decline in serum PTH of 0.07 ng/ml before noon and a mean increase of 0.04 ng/ml after 8 PM. In primary hyperparathyroidism there was a mean decline in serum PTH before noon of 0.11 ng/ml and a mean increase of 0.11 ng/ml after 8 PM. In both groups, the lowest mean serum calcium values were noted between midnight and 6:00 AM. Patients with pseudohypoparathyroidism showed a nocturnal increase in serum PTH. In each of two normal subjects, two patients with primary hyperparathyroidism, and two patients with pseudohypoparathyroidism, calcium, 4 mg/kg body weight per hour for 4 hours (8:00 PM to 12 midnight), produced hypercalcemia and prevented the nocturnal increase in serum PTH. We have concluded that a diurnal variation in serum PTH often occurs in both normal subjects and in patients with primary or secondary hyperparathyroidism and that nocturnal increases in serum PTH can be prevented by induced hypercalcemia.
Organic solvent vapor sensing using porous photopolymer photonic bandgap structures (2005)

Significant research efforts have been focused on the development of effective means for the optical detection of organic molecules using porous one-dimensional photonic bandgap (PBG) structures. To date, efforts have been focused on porous silicon microstructures, which are typically created using a controlled electrochemical etching process in a hydrofluoric acid solution. Generally, these sensors rely on changes in the optical resonance that occurs when the porous structure is filled by the analyte of interest and allows for simple and effective optical detection schemes. Here, we present a simple method for the production of polymer Bragg reflection gratings containing periodic porous layers, and we demonstrate optical detection of organic solvent vapors using these structures. To create the structures, a pre-polymer syrup containing a monomer, a photoinitiator, a co-initiator, liquid crystals (LC), and a non-reactive solvent (acetone or toluene) is sandwiched between two pieces of glass, and the periodic structure is then formed by applying an optical interference pattern generated using a simple one-beam laser setup. More importantly, we demonstrate that acetone vapor penetrates the porous structure and induces a change in the effective refractive index of these gratings that result in a shift in the reflection wavelength. This shift is pronounced, and can easily be observed by eye, or detected by optical means. We also demonstrate that this shift depends on the particular type of chemical vapor and vapor concentration, and the detection is reversible and repeatable. Finally, the addition of aminosilane to the pre-polymer syrup is shown to improve the stability of the resulting gratings, suggesting that this photopolymer fabrication technique could be used to create structures suitable for biological applications in aqueous environments.
Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus. (1995)

The production of potentially pathogenic anti-DNA autoantibodies in SLE is driven by special, autoimmune T helper (Th) cells. Herein, we sequenced the T cell receptor (TCR) alpha and beta chain genes expressed by 42 autoimmune Th lines from lupus patients that were mostly CD4+ and represented the strongest inducers of such autoantibodies. These autoimmune TCRs displayed a recurrent motif of highly charged residues in their CDR3 loops that were contributed by N-nucleotide additions and also positioned there by the recombination process. Furthermore, Th lines from four of the five patients showed a marked increase in the usage of the V alpha 8 gene family. Several independent Th lines expressed identical TCR alpha and/or beta chain sequences indicating again antigenic selection. 10 of these Th lines could be tested further for antigenic specificity. 4 of the 10 pathogenic anti-DNA autoantibody-inducing Th lines responded to the non-histone chromosomal protein HMG and two responded to nucleosomal histone proteins; all presented by HLA-DR molecules. Another Th line responded to purified DNA more than nucleosomes. Thus, these autoimmune Th cells of lupus patients respond to charged epitopes in various DNA-binding nucleoproteins that are probably processed and presented by the anti-DNA B cells they selectively help.
Detection of emphysema in rat lungs by using magnetic resonance measurements of <sup>3</sup> He diffusion (2000)

Emphysema is a pulmonary disease characterized by alveolar wall destruction, resulting in enlargement of gas exchange spaces without fibrosis. This condition is a part of chronic obstructive pulmonary disease (COPD), which causes 3.5% of deaths worldwide [Anonymous (1990) World Health Stat. Q. Special, 1-51] and contributes greatly to the global burden of disease [Murray, C. J. & Lopez, A. D. (1996) Science 274, 740-743]. Alveolar regeneration has been shown in animal models and could have potential for clinical treatment of early-stage emphysema. However, current techniques for detection of emphysema are not sensitive at the initial stages. Early-stage human panacinar emphysema is modeled in elastase-treated animals. Here, we provide an in vivo imaging method for differentiating normal and emphysematous rat lungs by measuring the apparent diffusion coefficient (ADC) of hyperpolarized (3)He by using magnetic resonance imaging. These data show that the ADC is significantly larger in elastase-treated rats, indicating alveolar expansion. Whereas these rats were clinically asymptomatic, conventional histology confirmed presence of injury. Our results indicate that measurement of the hyperpolarized (3)He ADC can be a valuable research tool and has potential application in the clinical setting.
Production of phosphor (YAG∶Tb) fine particles by hydrothermal synthesis in supercritical water (1999)

Rapid and continuous production of phosphor (YAG∶Tb) fine particles by hydrothermal synthesis in supercritical water was studied. At temperatures higher than the critical temperature of water, continuous and rapid (<60 s) production of YAG∶Tb fine particles was achieved. Emission spectra obtained by UV excitation of the particles were in agreement with the typical spectral pattern of YAG∶Tb. Single phase YAG∶Tb was produced by using stoichiometric mixtures of metal salts [Al(NO 3 ) 3 , Y(NO 3 ) 3 , and TbCl 3 ] as aqueous solutions with an alkali molar ratio {[OH – ]/([NO 3 – ] + [Cl – ])} of 1 and a rapid heating method. No additional thermal treatment was necessary to obtain crystalline products.
Selective adenosine A<sub>2A</sub> receptor agonist, ATL‐146e, attenuates stress‐induced gastric lesions in rats (2005)

A specific adenosine A(2A) agonist inhibits stress-induced gastric inflammation and damage. A(2A) agonist compounds may be useful for preventing ulcers and appear to act by blocking gastric inflammation.
PROSTATE SPECIFIC ANTIGEN REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION ASSAY IN PREOPERATIVE STAGING OF PROSTATE CANCER (1997)

The role of molecular techniques in prostate cancer evaluation and prognosis continues to emerge. However, in our study we demonstrate no significant advantage in preoperative staging of prostate cancer using RT-PCR assay with PSA primers.
Thermodynamic and Kinetic Data for Macrocycle Interaction with Cations, Anions, and Neutral Molecules (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic and Kinetic Data for Macrocycle Interaction with Cations, Anions, and Neutral MoleculesReed M. Izatt, Krystyna. Pawlak, Jerald S. Bradshaw, and Ronald L. BrueningCite this: Chem. Rev. 1995, 95, 7, 2529–2586Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/cr00039a010https://doi.org/10.1021/cr00039a010research-articleACS PublicationsRequest reuse permissionsArticle Views4080Altmetric-Citations751LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (90)»Supporting Information Supporting Information Get e-Alerts