gebhart/patrepeval huggingface dataset:
Heterogeneity of outer membrane proteins in Borrelia burgdorferi: comparison of osp operons of three isolates of different geographic origins (1992)

Biochemical and immunochemical studies of the outer membrane proteins of Borrelia burgdorferi have shown that the OspA and OspB proteins from strains of different geographic origins may differ considerably in their reactivities with monoclonal antibodies and in their apparent molecular weights. To further characterize this variation in Osp proteins between strains, the osp operons and deduced translation products from two strains, one from Sweden (ACAI) and one from eastern Russia (Ip90), were studied. Polyacrylamide gel electrophoresis and Western blot (immunoblot) analyses confirmed differences between ACAI, Ip90, and the North American strain B31 in their Osp proteins. The sequences of the ospA and ospB genes of ACAI and Ip90 were compared with that of the previously studied osp operon of B31 (S. Bergström, V. G. Bundoc, and A. G. Barbour, Mol. Microbiol. 3:479-486, 1989). The osp genes of ACAI and Ip90, like the corresponding genes of B31, were found on plasmids with apparent sizes of about 50 kb and are cotranscribed as a single unit. Pairwise comparisons of the nucleotide sequences revealed that the ospA genes of ACAI and Ip90 were 85 and 86% identical, respectively, to the ospA gene of strain B31 and 86% identical to each other. The ospB sequences of these two strains were 79% identical to the ospB gene of B31 and 81% identical to each other. There was significantly greater similarity between the ospA genes of the three different strains than there was between the ospA and ospB genes within each strain. These studies suggest that the duplication of osp genes in B. burgdorferi occurred before the geographical dispersion of strains represented by ACAI, Ip90, and B31.
Initial Development of an Ion-Based Bidirectional Flow Sensor (2006)

A novel method for monitoring air or dilute air-fuel mixture flow is initially developed and tested. Although many flow sensors are commercially available, none appear to have the combination of harsh environment durability (>600degC), fast response, bidirectional flow sensitivity, and low pressure drop desired for the application in hybrid power generation systems. The flow sensor described here uses the ions produced in a hydrocarbon flame to seed the gas flow, and then detects the current resulting from the flow induced drift of charged species in two directions from the flame source. Initial results show that the sensor is sensitive to flow reversal, but suffers from difficulties with flame blowout at high gas velocities
Optical receivers for optoelectronic VLSI (1996)

We describe our work on the design and testing of optical receivers for use in optoelectronic VLSI. The local nature of the optoelectronic VLSI system permits novel receiver designs, incorporating multiple optical beams and/or synchronous operation, while the requirement of realizing large numbers of receivers on a single chip severely constrains area and power consumption. We describe four different receiver designs, and their different operating modes. Results include 1-Gb/s high-impedance, two-beam diode-clamped FET-SEED receivers, single and dual-beam transimpedance receivers realized with a hybrid attachment of multiple-quantum well devices to 0.8-/spl mu/m linewidth CMOS operating to 1 Gb/s, and synchronous sense-amplifier-based optical receivers with low (/spl sim/1 mW) power consumption. Finally, we introduce a measure of receiver performance that includes area and power consumption.
High-power multiple-quantum-well GaInAsSb/AlGaAsSb diode lasers emitting at 2.1 μm with low threshold current density (1992)

The first GaInAsSb/AlGaAsSb diode lasers with a quantum-well active region have been demonstrated. These devices, which were grown by molecular beam epitaxy, emit at ∼2.1 μm. For room-temperature pulsed operation of lasers 100 μm wide, threshold current density as low as 260 A/cm2 and differential quantum efficiency up to 70% have been obtained for cavity lengths of 2000 and 300 μm, respectively. One device 100 μm wide and 1000 μm long has operated pulsed at heatsink temperatures up to 150 °C, with a characteristic temperature of 113 K between 20 and 40 °C. For another device of the same dimensions, cw output power up to 190 mW/facet has been achieved at a heatsink temperature of 20 °C. These characteristics represent a dramatic improvement in performance over double-heterostructure GaInAsSb/AlGaAsSb diode lasers.
Natural discharge after pulse and cooperative electrodes to enhance droplet velocity in digital microfluidics (2014)

Digital Microfluidics (DMF) is a promising technology for biological/chemical micro-reactions due to its distinct droplet manageability via electronic automation, but the limited velocity of droplet transportation has hindered DMF from utilization in high throughput applications. In this paper, by adaptively fitting the actuation voltages to the dynamic motions of droplet movement under real-time feedback monitoring, two control-engaged electrode-driving techniques: Natural Discharge after Pulse (NDAP) and Cooperative Electrodes (CE) are proposed. They together lead to, for the first time, enhanced droplet velocity with lower root mean square voltage value.
Histological analysis of calcium phosphate bone grafts for surgically created periodontal bone defects in dogs (2008)

A calcium phosphate cement (CPC-1), prepared by mixing an equimolar mixture of tetracalcium phosphate and dicalcium phosphate anhydrous with water, has been shown to be highly biocompatible and osteoconductive. A new type of calcium phosphate cement (CPC-2), prepared by mixing a mixture of alpha-tricalcium phosphate and calcium carbonate with pH 7.4 sodium phosphate solution, was also reported to be highly biocompatible. The objective of the present study was to compare the osteoconductivities of CPC-1 and CPC-2 when implanted in surgically created defects in the jaw bones of dogs. At 1 month after surgery, implanted CPC-1 was partially replaced by new bone and converted to bone within 6 months. In comparison, at 1 month after surgery, the defect filled with CPC-2 was mostly replaced by new bone. Therefore, bone formation in CPC-2-filled pocket was more rapid than in CPC-1-filled pocket. These findings supported the hypothesis that CPC-2 converted to bone more rapidly than CPC-1.
Hot-Spot Thermal Management With Flow Modulation in a Microchannel Heat Sink (2005)

Recesses created in the lid of a microchannel heat sink can serve to modulate the flow, resulting in local and global heat transfer enhancement. Numerical analysis of laminar flow and heat transfer in such a modified microchannel heat sink has shown an augmentation of heat transfer without an added penalty of increased pressure drop. The presence of the recesses reduces the overall flow friction and thus pressure drop. The flow expansion into the recesses and the subsequent contraction into the downstream region causes significant local enhancement in heat transfer. Both the maximum and average wall temperatures are decreased as a result. The heat transfer is locally enhanced, by as much as 150% in the regions just downstream of the recesses due to the re-initialization of boundary layers as the flow re-enters the microchannels. The potential for hot-spot mitigation in microelectronics devices using this approach is discussed.
Screening for BRCA2 mutations in 81 Dutch breast–ovarian cancer families (2000)

We have analysed 81 families with a history of breast and/or ovarian cancer for the presence of germline mutations in BRCA2 with a number of different mutation screening techniques. The protein truncation test (PTT) for exons 10 and 11 detected four different frame-shifting mutations in six of these families. Four of the remaining 75 families had given positive linkage evidence for being due to BRCA2. In these families the entire coding region was analysed by single-strand conformational polymorphism, leading to the detection of a non-sense and a splice-site mutation in two of them. While these studies were in progress, Southern analysis of BRCA1 revealed that in our study-population of 81 families, 15 families were segregating either the exon 13 or exon 22 deletion in BRCA1 (Petrij-Bosch et al (1997) Nat Genet 17: 341-345). This prompted us to examine BRCA2 in the remaining 58 families by Southern analysis, using two different restriction enzymes. No aberrations were found in the restriction patterns. Thus, contrary to BRCA1, large genomic rearrangements within the BRCA2 gene do not represent a major mutation mechanism among Dutch breast cancer families.
B29 Development of Automatic Diagnosis System for Golf Swing (2010)

An easy and economic system to automatically diagnose golf swings has been developed. The system takes 180 photos and selects 12 images required for diagnosis of the golfer's swing. Swing positions are detected by extracting the body silhouette in selected images and identifying colored marks on clothing. Results of the analysis are then compared with a standard swing. The system then generates suggestions for improving the golfer's swing, as well as, practice method recommendations.
Dual gate MOS thyristor (DGMOT) (2002)

A novel MOS-gated thyristor structure called the dual-gate MOS thyristor (DGMOT) is proposed. In this device the insulated-gate bipolar transistor (IGBT) mode turn-off is attained due to the integration of a lateral n-MOSFET with the thyristor structure, while the thyristor mode operation is achieved in the on-state. Consequently, the on-state voltage of the DGMOT is much lower than that of the IGBT with almost the same turn-off time. This result suggests that the DGMOT could be a superior alternative to the IGBT for a low-frequency circuit.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lightweight, stable, and rechargeable battery with an activated carbon fibre electrode (1982)

T. Nogami, M. Nawa and H. Mikawa, J. Chem. Soc., Chem. Commun., 1982, 1158 DOI: 10.1039/C39820001158
Fast Affine Projection Adaptation Algorithms With Stable and Robust Symmetric Linear System Slovers (2007)

This paper proposes two noniterative approaches to solve a symmetric linear system associated with the fast affine projection adaptation algorithm. The first approach, using matrix LDL <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sup> factorization, can provide an exact solution at a moderate complexity, in contrast with the fact that existing stable approaches are all approximate. Based on a reciprocating recursion scheme, the second approach has a very low complexity and gives a good approximate solution. Steady-state and transient properties of the proposed and certain previous FAP algorithms are studied in detail. Being stable and optimal under all step size conditions, fast affine projection algorithms incorporating the proposed approaches are promising in telecom and other applications of adaptive filtering
COMBINED SPECIFIC IGG – AND IGA-BASED DIAGNOSIS OF TUBERCULOSIS IN AFRICAN PRIMARY HEALTHCARE CLINIC ATTENDEES WITH SIGNS AND SYMPTOMS SUGGESTIVE OF TUBERCULOSIS (2017)

Background IgG-based tests for the diagnosis of active tuberculosis disease (TB) often show a lack of specificity in TB endemic regions, which is mainly due to a high background prevalence of latent TB infection (LTBI). Here, we investigate the combined performance of the responses of different Ig classes to selected mycobacterial antigens in primary healthcare clinic attendees with signs and symptoms suggestive of TB. Methods We evaluated the sensitivity and specificity of serologic IgA, IgG and/or IgM to LAM, 7 mycobacterial protein antigens (ESAT-6, Tpx, PstS1, AlaDH, MPT64, 16 kDa and 19 kDa) and 2 antigen combinations (TUB, TB-LTBI) in the plasma of 42 individuals with other respiratory diseases (separated into 21 LTBI controls and 21 uninfected healthy controls), and 21 active TB patients at baseline, of whom 19 were followed up at month 6 at the end of TB treatment. Results The leading single serodiagnostic markers were anti-16 kDa IgA, anti-MPT64 IgA, anti-LAM IgG and anti-TB-LTBI IgG. IgA responses to MPT64 and 16 kDa had the highest sensitivity/specificity of 95%/95% and 95%/90% in differentiating active TB from other respiratory diseases and active TB from LTBI controls, respectively. The combined use of 3 or 4 antibodies further improved this performance to accuracies above 95%. After successful completion of anti-TB treatment at month 6, only particularly anti-TUB IgG showed distinctively decreased levels. Conclusions These results show the potential of combining IgG and IgA responses against selected protein and non-protein antigens in differentiating active TB from other respiratory diseases in TB endemic settings, and may provide a benchmark for vaccines.
Distinct function of monoclonal antibody to TRAIL‐R2 as potentiator or inhibitor of the ligand TRAIL‐induced apoptosis (2005)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) specifically induces apoptosis in tumor cells but may be toxic to human hepatocytes. Although hepatocytes are susceptible to apoptotic signals mediated by TRAIL-receptor 2 (TRAIL-R2), we previously reported that some anti-TRAIL-R2 monoclonal antibodies (mAbs) produce little hepatocyte toxicity. Those mAbs neutralized the cytotoxic activity of TRAIL by inhibiting receptor-ligand binding. The hepatocyte-toxic mAbs did not compete with TRAIL for binding to TRAIL-R2, and potentiated ligand activity in both cancer cells and hepatocytes. A neutralizing antibody to TRAIL inhibited hepatocyte death by anti-TRAIL-R2 mAbs, suggesting that the toxicity may reflect their ability to potentiate membrane-bound TRAIL on hepatocytes.
Pathology of CAG repeat diseases (2000)

Neuronal intranuclear inclusions have become the neuropathological signature of the CAG repeat diseases, although their cytotoxicity is a matter of controversy. It has been demonstrated that the inclusions in dentatorubral-pallidoluysian atrophy (DRPLA) and Machado-Joseph disease (MJD) were immunopositive for several transcription factors such as TATA-binding protein (TBP), TBP-associated factor (TAF(II)130), Sp1, cAMP-responsive element-binding protein (CREB) and CREB-binding protein, suggesting that neuronal degeneration in polyglutamine diseases may result from nuclear depletion of transcription factors containing the glutamine-rich domain. It was also revealed that, in the DRPLA brain, expanded polyglutamine stretches were diffusely accumulated in neuronal nucleoplasm. This nuclear pathology involved many neurons in various nervous system regions, such as the cerebral cortex, thalamus, substantia nigra, pontine nuclei, reticular formation and inferior olive, in addition to the previously recognized affected regions. The diffuse nuclear labeling was also detected in MJD, Huntington's disease, and spinal and bulbar muscular atrophy, suggesting that this nuclear pathology may be a characteristic feature and may exert certain influence on certain nuclear functions of many neurons in the CAG repeat diseases.
Position Estimation of Tranceivers in Communication Networks (2003)

With the rapid development in wireless sensor networks, there is an important need for transceiver position estimation independent of Global Positioning Systems (GPS) [1,3]. While GPS might be useful for outdoor sensor nodes, it is not for indoor node localization. In this case, position estimation is possible through network range estimates from time-of-flight (TOF) measurements, a technique well suited to large bandwidth physical links, such as in ultra-wideband (UWB) communications. For example, in our UWB systems, with pulse duration less than 200 pico-seconds, range can easily be resolved to less than a foot. Assuming an encoded UWB or spread spectrum physical layer, we developed algorithms and simulation tools to test transceiver position localization. Simulations were designed to lend insight into system characteristics such as position error sensitivities to network geometry, to range estimation errors, and to number of sensor nodes.
Mode field diameter measurements in single-mode optical fibers (1989)

The role of the mode field diameter in the characterization of single-mode fibers is examined. The most relevant definitions of this parameter are reviewed, and a comparative analysis of methods for its measurement is performed. All the discussed measurement methods have reached a repeatability and reproducibility which are quite satisfying. Emphasis is given to the requirements posed by the new fiber designs, such as the polarization-maintaining structures. Most of the discussed techniques have been industrialized, and a number of instruments based on them are commercially available; however, it is predicted that the evolution of fiber design will impose new requirements on some of these instruments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Performance evaluation and multicentre study of a von Willebrand factor activity assay based on GPIb binding in the absence of ristocetin (2014)

The functional activity of von Willebrand factor (VWF) is most frequently measured by using the ristocetin cofactor assay (VWF:RCo). However, the method's drawbacks include unsatisfactory precision, sensitivity and availability of automated system applications. We have developed an alternative assay (INNOVANCE VWF Ac) that is based on the binding of VWF to recombinant glycoprotein Ib (GPIb). Two gain-of-function mutations were introduced into a GPIb fragment, allowing an assay format without ristocetin. Fully automated assay applications are available for the BCS/BCS XP systems and the Sysmex CS-2000i, Sysmex CA-7000, Sysmex CA-1500 and Sysmex CA-560 systems.The INNOVANCE VWF Ac assay measuring range extends from 4 to 600% VWF for all systems except the Sysmex CA-560 system. Within-device precision values were found to be between 2 and 7%. The limit of detection was below 2.2% VWF. In a study on the BCS XP system, a total number of 580 sample results yielded a correlation to the VWF:RCo assay of r equal to 0.99 (slope = 0.96). Very similar results were observed when von Willebrand disease samples type 1, 2A, 2B, 2M, 2N and 3 were investigated with the new assay and the VWF:RCo assay. The excellent performance data and comparability to VWF:RCo, together with the ease of use, led us to the conclusion that the ristocetin cofactor assay can be replaced by the new GPIb-binding assay to reliably diagnosing patients with von Willebrand disease.
Supporting multi-party voice-over-IP services with peer-to-peer stream processing (2005)

Multi-party voice-over-IP (MVoIP) services provide economical and natural group communication mechanisms for many emerging applications such as on-line gaming, distance collaboration, and tele-immersion. In this paper, we present a novel peer-to-peer (P2P) stream processing system called peerTalk to provide resource-efficient and failure-resilient MVoIP services. Different from previous work, our solution is fully distributed and self-organizing without requiring specialized servers or IP multicast support. Particularly, we decouple the stream processing in MVoIP services into two phases: (1) aggregation phase that mixes audio streams from active speakers into a single stream; and (2) distribution phase that distributes the mixed audio stream to all listeners. The decoupled model allows us to optimize and adapt the P2P stream mixing and distribution processes separately. Specifically, we can adaptively spread stream mixing workload among resource-constrained peer hosts according to current speaking activities. We have implemented a prototype of the peerTalk system and conducted experiments in real-world wide-area networks. The results show that peerTalk can achieve lower resource contention and better service quality than previous common solution.
Transmissive infrared frequency selective surfaces and infrared antennas : final report for LDRD 105749. (2009)

Plasmonic structures open up new opportunities in photonic devices, sometimes offering an alternate method to perform a function and sometimes offering capabilities not possible with standard optics. In this LDRD we successfully demonstrated metal coatings on optical surfaces that do not adversely affect the transmission of those surfaces at the design frequency. This technology could be applied as an RF noise blocking layer across an optical aperture or as a method to apply an electric field to an active electro-optic device without affecting optical performance. We also demonstrated thin optical absorbers using similar patterned surfaces. These infrared optical antennas show promise as a method to improve performance in mercury cadmium telluride detectors. Furthermore, these structures could be coupled with other components to lead to direct rectification of infrared radiation. This possibility leads to a new method for infrared detection and energy harvesting of infrared radiation.
IMPROVED RESOURCE UTILIZATION WITH BUFFERED COSCHEDULING (2001)

We present buffered coscheduling, a new methodology to multitask parallel jobs in a message-passing environment and to develop parallel programs that can pave the way to the efficient implementation of a distributed operating system. Buffered coscheduling is based on three innovative techniques: communication buffering, strobing, and non-blocking communication. By leveraging these techniques, we can perform effective optimizations based on the global status of the parallel machine rather than on the limited knowledge available locally to each processor The advantages of buffered coscheduling include higher resource utilization, reduced communication overhead, efficient implementation of flow-control strategies and fault-tolerant protocols, accurate performance modeling, and a simplified yet ;.till expressive parallel programming model which offloads many resource-management tasks to the operating system. Preliminary experimental results show that buffered coscheduling is very effective in increasing the overall performance in the presence of load imbalance and communication-intensive workloads and is relatively insensitive to the local process scheduling strategy.
Targeted Advertising on the Web with Inventory Management (2003)

Companies that maintain Web sites can make considerable revenue by running advertisements, and they therefore compete to attract advertisers. The ability to deliver high click-through rates on a site can attract advertisers and, under an appropriate pricing model, can also increase revenue directly. Consequently, companies can benefit from delivery systems that display advertisements selectively to those visitors most likely to click though. To satisfy contractual obligations, however, these systems must simultaneously manage inventory. We developed a delivery system that maximizes click-through rate given inventory-management constraints in the form of advertisement quotas. The system uses predictive segments in conjunction with a linear program to perform the constrained optimization. Using a real Web site (msn.com), we demonstrated the efficacy of the system. We can generalize our system to find revenue-optimal advertisement schedules under a wide variety of pricing models.
Fast Private Set Intersection from Homomorphic Encryption (2017)

Private Set Intersection (PSI) is a cryptographic technique that allows two parties to compute the intersection of their sets without revealing anything except the intersection. We use fully homomorphic encryption to construct a fast PSI protocol with a small communication overhead that works particularly well when one of the two sets is much smaller than the other, and is secure against semi-honest adversaries.