gebhart/patrepeval huggingface dataset:
Harvesting traffic-induced bridge vibrations (2011)

This paper demonstrates the harvesting of low-frequency and low-amplitude vibration energy from a suspension bridge. The performance of a Parametric Frequency Increased Generator (PFIG) is evaluated at different locations along the bridge. Bridge vibrations have very low acceleration 0.1-1 m/s <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and variable frequency characteristics (1-40 Hz), making them very challenging to harvest. Field test results show consistent operation along the length of the bridge, producing 0.46-0.72 μW of continuous (average) power (peaks in the range of 30-100 μW), independent of the location of the harvester on the bridge, and without any modifications or tuning. These results pave the way for installing a network of wireless structural health monitoring sensors throughout the bridge without regard to the specific characteristics of the vibration at each location. The fabricated device has a volume of 43 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> (68 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> including casing).
Irán y la represión gubernamental en la era digital (2023)

En el contexto general de la represión gubernamental en una época caracterizada por el uso de las tecnologías de información, el artículo toma como caso de estudio a la República Islámica de Irán y se enfoca sobre los dos periodos más significativos de movilizaciones populares en contra del régimen postrevolucionario hasta la fecha: las protestas electorales de 2009 y el llamado “Noviembre sangriento” de 2019. La comparación de ambos episodios sirve para identificar algunas tendencias significativas en el desarrollo de la protesta y la represión durante el periodo, particularmente el establecimiento de la censura de las telecomunicaciones como columna vertebral de la estrategia represiva oficial y el desarrollo de nuevas tecnologías con este objetivo. Otros hallazgos significativos están relacionados con el uso cada vez más severo de la violencia en el contexto de las protestas populares y con la demografía cambiante de los ciudadanos iraníes que están dispuestos a participar en estos movimientos. Finalmente, el artículo muestra la disposición del régimen iraní por adaptar constantemente sus tácticas represivas en respuesta a los desafíos a su autoridad.
An Integrated, Innovative Solution to Optimize Hydrocarbon Production Through the use of a Workflow Oriented Approach (2008)

Abstract Today's hydrocarbon environment requires depth of knowledge and expertise combined with technology innovation and integration across the various disciplines involved in the Reservoir Management cycles going from exploration to production, in order to increase production, reserves and improve operational efficiency. An integrated approach including People, Process and Technology is necessary to break the barriers between the various reservoir management cycles - operations - production optimization and field management, and to improve the maturity of information to knowledge. Engineering processes related to each reservoir management cycle need to be accelerated by the implementation of automated/ & interactive workflows, integrating various levels of field data frequency with petrotechnical processes, that can help in operational efficiency, leaving more time for a more proactive engineering analysis of problems and solutions. A successful workflow approach ensures that the hydrocarbon's decline curve is mitigated with higher ultimate recovery. Also, the integration of data with numerical and analytical reservoir and well models, through workflows, helps to bring more efficiency in the field planning cycle in order to establish proper Enhanced Oil Recovery (EOR) or in-fill drilling plans to increase recovery factors. The purpose of this paper is to show how workflow oriented solutions, within the context of the Digital Oilfield, have helped increase production, ultimate recovery factors and operational efficiency in various types of operational environments, and i.e. water flooding, Water Alternating Gas (WAG) and gas lifted fields.
A new type of grid (1977)

A new type of grid is discussed. It is anticipated that it will have the same primary transmission as and will eliminate scatter more efficiently than a conventional linear grid of equal thickness and lead content. The construction of the new type of grid is similar to a conventional one except that the lead strips are arranged in zigzag rather than linear pattern. Geometrically ideal “zigzag” and linear grids were constructed and their performance tested. The scatter transmitted by the ideal zigzag grid was one‐half that of the comparable ideal linear grid. The implications regarding the improved scatter‐eliminating capabilities of a practical zigzag grid are discussed.
Cancer/Testis Antigens: Structural and Immunobiological Properties (2002)

Characterization of tumor-associated antigens recognized by cytotoxic T lymphocytes which has evolved during recent years opens new possibilities for specific anti-cancer immunotherapy. Among different groups of tumor-associated antigens, cancer/testis (CT) antigens (expressed in many tumors and among normal tissues only in testes) represent the most perspective antigens for immunotherapy because of their broad tumor-specific expression. More than 50 CT antigens have been described so far and, for many of them, epitopes recognized by T lymphocytes have been identified. The most studied group of CT antigens is the MAGE proteins, which form the so-called MAGE superfamily, together with some MAGE-like proteins that have a different distribution than classical CT antigens. The MAGE superfamily includes five families: MAGE-A, MAGE-B, MAGE-C, MAGE-D, and necdin. Comparison of the structure of members of MAGE superfamily points to the existence of a domain organization of these proteins. The central, core domain (second domain) is highly conservative. The first domain is homologous among MAGE family members with a CT expression, but unique for each member of the MAGE-D and necdin families. In addition to the homology of the central domain, the third domain is also homologous among all members of MAGE superfamily, but to a much lesser extent. The MAGE-D proteins contain an additional, fourth domain, which in the case of MAGE-D3 coincides with trophinin, a separate molecule described previously as an adhesion molecule that participates in embryo implantation. The structural classification of the members of MAGE superfamily might help in the future to understand the biological function of MAGE proteins. One important property of the CT antigens is the up-regulation of their expression by DNA demethylating agents, indicating a possible mechanism for their re-expression in tumors. One of the implications of this particular property could be that a combination of immunotherapy targeting CT antigens with chemotherapy inducing up-regulation of CT antigens might result in more efficient tumor eradication.
Au<sub>19</sub> Nanocluster Featuring a V-Shaped Alkynyl–Gold Motif (2014)

A novel Au19 nanocluster with a composition of [Au19(PhC≡C)9(Hdppa)3](SbF6)2 was synthesized (Hdppa = N,N-bis(diphenylphosphino)amine). Single crystal X-ray structural analysis reveals that the cluster comprises a centered icosahedral Au13 core hugged by three V-shaped PhC≡C-Au-C≡C(Ph)-Au-C≡CPh motifs. Such motif is observed for the first time in an alkynyl-protected gold nanocluster. The Au19 cluster shows two main optical-absorption bands at 1.25 and 2.25 eV, confirmed by time-dependent density functional theory. Orbital analysis indicates that PhC≡C- groups can actively participate in the frontier orbitals of the whole cluster. The new Au19 cluster and the novel alkynyl-gold motif open the door to understanding the alkynyl-gold interface and discovering many potential members of this new class of gold clusters.
Quantitative Three-Dimensional Analysis of the Intracellular Trafficking of Plasmid DNA Transfected by a Nonviral Gene Delivery System Using Confocal Laser Scanning Microscopy (2004)

Since endosomal escape and the nuclear delivery of plasmid DNA (pDNA) constitute major barriers for transgene expression, a quantitative evaluation of intracellular trafficking of pDNA would be highly desirable in terms of optimizing a nonviral gene delivery system. In the present study, a novel strategy is proposed for the quantification of rhodamine-labeled pDNA in endosomes/lysosomes, cytosol, and nucleus. Endosomes/lysosomes and nucleus were stained with LysoSensor DND-189 and Hoechst 33258, respectively, to distinguish them from the cytosol. The pixel areas of the clusters derived from the rhodamine were used as an index for the amount of pDNA. This approach was applied to the analysis of the intracellular trafficking of pDNA transfected by LipofectAMINE PLUS, stearylated octaarginine (STR-R8), and octaarginine (R8). In the case of R8, most of the pDNA was trapped by endosomes/lysosomes. STR-R8 exhibited endosomal escape followed by nuclear translocation in a time-dependent manner. LipofectAMINE PLUS was the most effective in rapidly delivering pDNA to the nucleus as well as the cytosol. These differences in the intracellular trafficking of pDNA correlated well with the transgene expression. Therefore, this method enables the quantitative analysis of the intracellular pharmacokinetics of pDNA and promises to provide useful information for optimizing nonviral gene delivery systems.
A new integrated silicon gate technology combining bipolar linear, CMOS logic, and DMOS power parts (1986)

This paper describes a new mixed technology, called Multipower BCD, that, starting from the merging of the VDMOS silicon gate process with the conventional junction isolation process, allows the integration on a single chip of bipolar linear, CMOS logic, and DMOS power functions. The architecture of the process was chosen to optimize the power part, which generally occupies the most chip area. With the DMOS device, many other signal components have been obtained whose electrical and structural characteristics are discussed in relation to some process variables. Many test vehicles have been processed to evaluate the different structures and a first electrical application of the technology is indicated.
Serotonin Is Associated with Coronary Artery Disease and Cardiac Events (1999)

The study suggests that serotonin is associated with coronary artery disease and occurrence of cardiac events, particularly in younger age groups. This association seems to persist after adjustment for conventional risk factors.
Improved Intracranial Induced Electrical Field in Transcranial Magnetic Stimulation With Semiellipse Coil Pair (2018)

A novel method for obtaining superior intracranial focusing field in transcranial magnetic stimulation is proposed in this paper. In order to improve stimulation intensity and focalization, a semiellipse coil pair (SEP) of special coil configuration is designed and introduced. Projected onto a plane parallel to stimulating target, the two adjacent coils are in semiellipse shapes. From the front view, the SEP is bent along a symmetrical axis at specific angles. Finite-element method is adopted to analyze the relations between the geometric structure characteristics of SEP and the three-dimensional spatial distributions of the induced electromagnetic field produced by SEP. The SEP coil is compared to a conventional figure of eight coil by the positive peak value of intracranial induced electrical field and the focusing area at a target plane located 20 mm below the scalp. Results indicate that under similar power loss, the design of SEP makes it possible to enhance the positive peak value of induced electrical field and decrease the focusing area simultaneously. A real human head modeled as homogeneous and isotropic is occupied in this paper to verify our method.
Installation of high precision seismometer unit at the Ryukyu Trench using Guam-Okinawa geophysical submarine cable (GOGC: FOMER TPC-2 cable) (2002)

An ocean bottom broadband seismometer (OBBS) was installed 2170 m deep on the slope of the Ryukyu Trench with other sensors through the VENUS project. Prior to the installation of the OBBS unit, the bottom telemetry system, which supplies electrical power to the instruments, telemetry system and cable was installed on the ocean bottom by a method similar to cable repair works. Since broadband seismometers are extremely fragile, it was handled with special care. The installation of the seismometer was done by use of a deep-tow system and the ROV Kaiko-10 K. In September 1999, the OBBS unit was deployed at the target position, at 80-meter from the bottom telemetry system, with several meters allowances using a deep-tow system. To install the instrument at the exact location, the mother ship of the deep-tow system was precisely navigated. The connecting cable and eight weights were also dropped from the deep-tow system. The ROV Kaiko-10 K extended the 100 m-long connecting cable from the seismometer to the junction box and connected it to the junction box. The OBBS unit collected one and half month records. Several significant earthquakes near Japan, in Taiwan and San Francisco have been observed since the installation.
ChemInform Abstract: Total Synthesis (+)‐Rosaramicin Aglycone and Its Diacetate. (1986)

Abstract The title compound (X) can be synthesized starting from the reaction between the vinylogous urethane (II) and the aldehyde (I).
Booster Vaccination With GVGH Shigella sonnei 1790GAHB GMMA Vaccine Compared to Single Vaccination in Unvaccinated Healthy European Adults: Results From a Phase 1 Clinical Trial (2019)

The investigational <i>Shigella sonnei</i> vaccine (1790GAHB) based on GMMA (generalized modules for membrane antigens) is immunogenic, with an acceptable safety profile in adults. However, pre-vaccination anti-<i>S. sonnei</i> lipopolysaccharide (LPS) antibody levels seemed to impact vaccine-related immune responses. This phase 1, open-label, non-randomized extension study (ClinicalTrials.gov: NCT03089879) evaluated immunogenicity of a 1790GAHB booster dose in seven adults with undetectable antibodies prior to priming with three 1790GAHB vaccinations 2-3 years earlier (boosted group), compared to one dose in 28 vaccine-naïve individuals (vaccine-naïve group). Anti-<i>S. sonnei</i> LPS serum IgG geometric mean concentrations and seroresponse (increase of ≥25 EU or ≥50% from baseline antibody ≤ 50 EU and ≥50 EU, respectively) rates were calculated at vaccination (day [D]1), D8, D15, D29, D85. Safety was assessed. Geometric mean concentrations at D8 were 168 EU (boosted group) and 32 EU (vaccine-naïve group). Response peaked at D15 (883 EU) and D29 (100 EU) for the boosted and vaccine-naïve groups. Seroresponse rates at D8 were 86% (boosted group) and 24% (vaccine-naïve group) and increased at subsequent time points. Across both groups, pain (local) and fatigue (systemic) were the most frequent solicited adverse events (AEs). Unsolicited AEs were reported by 57% of boosted and 25% of vaccine-naïve participants. No deaths, serious AEs, or AEs of special interest (except one mild neutropenia case, possibly vaccination-related) were reported. One 1790GAHB dose induced a significant booster response in previously-primed adults, regardless of priming dose, and strong immune response in vaccine-naïve individuals. Vaccination was well tolerated.
Limits in accuracy and a strategy of RNA structure prediction using experimental information (2019)

RNA structural complexity and flexibility present a challenge for computational modeling efforts. Experimental information and bioinformatics data can be used as restraints to improve the accuracy of RNA tertiary structure prediction. Regarding utilization of restraints, the fundamental questions are: (i) What is the limit in prediction accuracy that one can achieve with arbitrary number of restraints? (ii) Is there a strategy for selection of the minimal number of restraints that would result in the best structural model? We address the first question by testing the limits in prediction accuracy using native contacts as restraints. To address the second question, we develop an algorithm based on the distance variation allowed by secondary structure (DVASS), which ranks restraints according to their importance to RNA tertiary structure prediction. We find that due to kinetic traps, the greatest improvement in the structure prediction accuracy is achieved when we utilize only 40-60% of the total number of native contacts as restraints. When the restraints are sorted by DVASS algorithm, using only the first 20% ranked restraints can greatly improve the prediction accuracy. Our findings suggest that only a limited number of strategically selected distance restraints can significantly assist in RNA structure modeling.
Triggered Release of Molecules across Droplet Interface Bilayer Lipid Membranes Using Photopolymerizable Lipids (2012)

A combination of nonpolymerizable phospholipids (DPPC or DPhPC) and a smaller amount of cross-linking photopolymerizable phospholipids (23:2 DiynePC) is incorporated in an unsupported artificial lipid bilayer formed using the droplet interface bilayer (DIB) approach. The DIB is formed by contacting lipid monolayer-coated aqueous droplets against each other in a dodecane-lipid medium. Cross-linking of the photopolymerizable lipids incorporated in the DIB was obtained by exposure to UV-C radiation (254 nm), resulting in pore formation. The effect of cross-linking on the DIB properties was characterized optically by measuring the diffusion of selectively encapsulated dye molecules (calcein) from one droplet of the DIB to the other droplet. Changes in DIB conductivity due to UV-C exposure were investigated using current-voltage (I-V) measurements. The leakage of dye molecules across the DIB and the increase in DIB conductivity after UV-C exposure indicates the formation of membrane pores. The results indicate that the DIB approach offers a simple and flexible platform for studying phototriggered drug delivery systems in vitro.
Automatic Temperature Controller for Multielement Array Hyperthermia Systems (2006)

This paper concerns the optimization and performance analysis of an automatic control algorithm for managing power output of large multielement array hyperthermia applicators. Simulation and corresponding measurement of controller performance in a solid tissue equivalent phantom model is utilized for analysis of controller response to dynamically varying thermal load conditions that simulate clinical treatments. The analysis leads to an optimum controller which demonstrates the ability to achieve a uniform and stable temperature profile over a large surface area regardless of surrounding thermal load. This paper presents several advancements to the performance of a previously published control routine, including: 1) simplified simulation techniques for thorough characterization of controller performance; 2) an optimization procedure leading to an improved hybrid control algorithm for maintaining optimal performance during periods of both "rising" and "steady-state" temperature; 3) performance analysis of a control algorithm tailored for large area hyperthermia treatments with a mulitelement array applicator. The optimized hybrid controller is applied to the conformal microwave array (CMA) hyperthermia system previously developed for heating large area surface disease such as diffuse chestwall recurrence of breast carcinoma, and shown to produce stable, uniform temperatures under the multielement array applicator for all thermal load conditions.
The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1 (2008)

Hsp90 is an ATP-dependent molecular chaperone whose mechanism is not yet understood in detail. Here, we present the first ATPase cycle for the mitochondrial member of the Hsp90 family called Trap1 (tumor necrosis factor receptor-associated protein 1). Using biochemical, thermodynamic, and rapid kinetic methods we dissected the kinetics of the nucleotide-regulated rearrangements between the open and the closed conformations. Surprisingly, upon ATP binding, Trap1 shifts predominantly to the closed conformation (70%), but, unlike cytosolic Hsp90 from yeast, this process is rather slow at 0.076 s(-1). Because reopening (0.034 s(-1)) is about ten times faster than hydrolysis (k(hyd) = 0.0039 s(-1)), which is the rate-limiting step, Trap1 is not able to commit ATP to hydrolysis. The proposed ATPase cycle was further scrutinized by a global fitting procedure that utilizes all relevant experimental data simultaneously. This analysis corroborates our model of a two-step binding mechanism of ATP followed by irreversible ATP hydrolysis and a one-step product (ADP) release.
The basic mechanics of bipedal walking lead to asymmetric behavior (2011)

This paper computationally investigates whether gait asymmetries can be attributed in part to basic bipedal mechanics independent of motor control. Using a symmetrical rigid-body model known as the compass-gait biped, we show that changes in environmental or physiological parameters can facilitate asymmetry in gait kinetics at fast walking speeds. In the environmental case, the asymmetric family of high-speed gaits is in fact more stable than the symmetric family of low-speed gaits. These simulations suggest that lower extremity mechanics might play a direct role in functional and pathological asymmetries reported in human walking, where velocity may be a common variable in the emergence and growth of asymmetry.
System R: An architectural overview (1999)

We have described the architecture of System R, including the Relational Data System and the Research Storage System. The RDS supports a flexible spectrum of binding times, ranging from precompilmion of “canned transactions” to on-line execution of ad hoc queries. The advantages of this approach may be summarized as follows: 1. For repetitive transactions, all the work of parsing, name binding, and access path selection is done once at precompilation time and need not be repeated. 2. Ad hoc queries are compiled on line into small machine-language routines that execute more efficiently than an interpreter. 3. Users are given a single language, SQL, for use in ad hoc queries as well as in writing PL/I and COBOL transaction programs. 4. The SQL parser, access path selection routines, and machine language code generator are used in common between query processing and precompilation of transaction programs. 5. When an index used by a transaction program is dropped, a new access path is automatically selected for the transaction without user intervention.