gebhart/patrepeval huggingface dataset:
Use of polymers and biopolymers for water retaining and soil stabilization in arid and semiarid regions (2010)

The use of polymers as a soil-stabilizer additive has expanded significantly in agricultural use to control soil degradation and desertification and also to improve arid and semi arid soils. This research was conducted to determine the effects of different synthetic polymers and biopolymers at low concentration (0.03 % - 1%) at arid and semi arid soil of North Africa. Polystyrene, Polyacrylamide; Cellulose and the mixture of Polyacrylamide with other polymers were characterized by viscosity, infrared spectroscopy, X-ray Diffractometry, thermal analysis (TG and DSC) and Scanning electron micrographs (SEM). The results showed that the polymer composites (10 mg /L Polyacrylamide and 0.5g / L Cellulose) in soil could improve better soil physical properties and augment 60 % water retention at arid soils compared with application of any other polymer at the same concentration. This work can help to improve the productivity of arid and semi arid soils by using low concentration of biopolymers from plant fibers and polymers from synthetic plastics compounds or wastes plastic industry to augment water holding capacity improve the physical properties of soils by binding soils particles together reducing the losses of water by evaporation and deep percoloration, and to make valuable products of plastic industry and renewable organic fibers to protect environment.
A versatile new synthesis of quinolines and related fused pyridines. Part 11. Conversion of acylanilides into α-iminopyridines (1983)

The Vilsmeier formylation of enamidines, readily derived by treatment of acetanilides with PCl5, allowed the synthesis of 6-chloro-1-aryl-2-iminopyridines. Similarly other acylanilides (RCH2CONHAr) gave 3,5-R2 disubstituted analogues.
Functionalized STAT1 siRNA Nanoparticles Regress Rheumatoid Arthritis in A Mouse Model (2011)

RGD functionalized PLGA nanoparticles encapsulating STAT1-targeted siRNAs are efficacious in the treatment of established arthritis, possibly through a selective inhibition of macrophage and dendritic cell activation.
A Strong Association between Mefloquine and Halofantrine Resistance and Amplification, Overexpression, and Mutation in the P-Glycoprotein Gene Homolog (pfmdr) of Plasmodium falciparum In Vitro (1994)

Stepwise selection for increased mefloquine resistance in a line of Plasmodium falciparum in vitro resulted in increased resistance to halofantrine and quinine, increased sensitivity to chloroquine, and amplification and overexpression of the P-glycoprotein gene homolog (pfmdr1). A point mutation (tyrosine to phenylalanine) noted at amino acid 86 in pfmdr1 in the mefloquine-resistant line W2mef was amplified in more resistant lines derived from it by in vitro selection pressure with mefloquine. Conversely, lines selected for increased chloroquine resistance exhibited a revertant phenotype that was sensitive to mefloquine and halofantrine. These lines also demonstrated increased sensitivity to quinine, loss of amplification of pfmdr1, loss of the mefloquine/halofantrine phenylalanine-86 mutation, and selection for a tyrosine-86 mutation previously associated with chloroquine resistance. These findings provide strong evidence for pfmdr1 mediating cross-resistance to halofantrine and mefloquine in P. falciparum in vitro.
Improving Practice (2008)

Cervical collars are necessary to stabilize the cervical spine of trauma patients but are known to contribute to the development of occipital pressure ulcers. A quality improvement project that began on one nursing unit stimulated the development of evidence-based practice guidelines and a multidisciplinary research study. As a result, a standardized plan of care and cervical collar recommendations were implemented, resulting in a sharp decline in the incidence of occipital pressure ulcers.
Nitrogen control of Salmonella typhimurium: co-regulation of synthesis of glutamine synthetase and amino acid transport systems (1979)

Nitrogen control in Salmonella typhimurium is not limited to glutamine synthetase but affects, in addition, transport systems for histidine, glutamine, lysine-arginine-ornithine, and glutamate-aspartate. Synthesis of both glutamine synthetase and transport proteins is elevated by limitation of nitrogen in the growth medium or as a result of nitrogen (N)-regulatory mutations. Increases in the amounts of these proteins were demonstrated by direct measurements of their activities, by immunological techniques, and by visual inspection of cell fractions after gel electrophoresis. The N-regulatory mutations are closely linked on the chromosome to the structural gene for glutamine synthetase, glnA: we discuss the possibility that they lie in a regulatory gene, glnR, which is distinct from glnA. Increases in amino acid transport in N-regulatory mutant strains were indicated by increased activity in direct transport assays, improved growth on substrates of the transport systems, and increased sensitivity to inhibitory analogs that are trnasported by these systems. Mutations to loss of function of individual transport components (hisJ, hisP, glnH, argT) were introduced into N-regulatory mutant strains to determine the roles of these components in the phenotype and transport behavior of the strains. The structural gene for the periplasmic glutamine-binding protein, glnH, was identified, as was a gene argT that probably encodes the structure of the lysine-arginine-ornithine-binding protein. Genes encoding the structures of the histidine- and glutamine-binding proteins are not linked to glnA or to each other by P22-mediated transduction; thus, nitrogen control is exerted on several unlinked genes.
Information Subspace-Based Fusion for Vehicle Classification (2018)

Union of Subspaces (UoS) is a new paradigm for signal modeling and processing, which is capable of identifying more complex trends in data sets than simple linear models. Relying on a bi-sparsity pursuit framework and advanced nonsmooth optimization techniques, the Robust Subspace Recovery (RoSuRe) algorithm was introduced in the recent literature as a reliable and numerically efficient algorithm to unfold unions of subspaces. In this study, we apply RoSuRe to prospect the structure of a data type (e.g. sensed data on vehicle through passive audio and magnetic observations). Applying RoSuRe to the observation data set, we obtain a new representation of the time series, respecting an underlying UoS model. We subsequently employ Spectral Clustering on the new representations of the data set. The classification performance on the dataset shows a considerable improvement compared to direct application of other unsupervised clustering methods.
Kidney Disease Is Parasite-Slaying Protein's Downside (2010)

Researchers describe two Jekyll-and-Hyde genetic variations online in Science this week that can lead to kidney shutdown but may also fend off a microorganism that causes sleeping sickness in thousands of people in Africa.
Company Law in the European Community: Toward Supranational Incorporation (1991)

This article attempts to present each piece of legislation completely and individually in answer to the practical need to know what the law is, and what it requires. Yet, these measures also constitute significant elements in a monumental project, and thus the article will also indicate how each piece fits into the whole developing framework of a European law of business organizations. The first section will discuss the Community's ongoing efforts to harmonize the company law of the Member States, using the recently adopted Twelfth Council Company Law Directive as an example. This first section will distinguish the project of harmonization from the enactment of supranational legislation. The second section will address the regulation that establishes the European Economic Interest Grouping. The third section will examine the controversial European Company Law Statute.
Learning to rank for quantity consensus queries (2009)

Web search is increasingly exploiting named entities like persons, places, businesses, addresses and dates. Entity ranking is also of current interest at INEX and TREC. Numerical quantities are an important class of entities, especially in queries about prices and features related to products, services and travel. We introduce Quantity Consensus Queries (QCQs), where each answer is a tight quantity interval distilled from evidence of relevance in thousands of snippets. Entity search and factoid question answering have benefited from aggregating evidence from multiple promising snippets, but these do not readily apply to quantities. Here we propose two new algorithms that learn to aggregate information from multiple snippets. We show that typical signals used in entity ranking, like rarity of query words and their lexical proximity to candidate quantities, are very noisy. Our algorithms learn to score and rankquantity intervals directly, combining snippet quantity and snippet text information. We report on experiments using hundreds of QCQs with ground truth taken from TREC QA, Wikipedia Infoboxes, and other sources, leading to tens of thousands of candidate snippets and quantities. Our algorithms yield about 20% better MAP and NDCG compared to the best-known collective rankers, and are 35% better than scoring snippets independent of each other.
Automatic measurement of fish size using stereo vision (2018)

In aquaculture, in order to optimize the feeding of fish, it is essential to know their size with precision. Most of the current systems either do not automatically determine the size of the fish in real time or the error in measurement is excessive. The proposed system enables automatic and real-time measurement using artificial vision techniques. To attain this goal, a two stages methodology was developed with the aim of optimizing time and development costs. In a first stage the results obtained in test environments only were collected and compared in order to obtain a good basis for the development and improvement of the measurement software. In a second stage, work was started in a real-world environment and a recursive process was started in which, based on the information obtained, both the test environments and the measurement software were improved. In this work the results obtained in test environments are shown, leaving for a later work the problem of measurement in the field.
Attenuation of Vaccinia Virus (2015)

Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now. The Lister vaccine strain (LIVP) of vaccinia virus was used as a parental virus for generating a recombinant 1421ABJCN clone defective in five virulence genes encoding hemagglutinin (A56R), the IFN-γ-binding protein (B8R), thymidine kinase (J2R), the complement-binding protein (C3L), and the Bcl-2-like inhibitor of apoptosis (N1L). We found that disruption of these loci does not affect replication in mammalian cell cultures. The isogenic recombinant strain 1421ABJCN exhibits a reduced inflammatory response and attenuated neurovirulence relative to LIVP. Virus titers of 1421ABJCN were 3 lg lower versus the parent VACV LIVP when administered by the intracerebral route in new-born mice. In a subcutaneous mouse model, 1421ABJCN displayed levels of VACV-neutralizing antibodies comparable to those of LIVP and conferred protective immunity against lethal challenge by the ectromelia virus. The VACV mutant holds promise as a safe live vaccine strain for preventing smallpox and other orthopoxvirus infections.
FireWorks: a dynamic workflow system designed for high‐throughput applications (2015)

Summary This paper introduces FireWorks, a workflow software for running high‐throughput calculation workflows at supercomputing centers. FireWorks has been used to complete over 50 million CPU‐hours worth of computational chemistry and materials science calculations at the National Energy Research Supercomputing Center. It has been designed to serve the demanding high‐throughput computing needs of these applications, with extensive support for (i) concurrent execution through job packing, (ii) failure detection and correction, (iii) provenance and reporting for long‐running projects, (iv) automated duplicate detection, and (v) dynamic workflows (i.e., modifying the workflow graph during runtime). We have found that these features are highly relevant to enabling modern data‐driven and high‐throughput science applications, and we discuss our implementation strategy that rests on Python and NoSQL databases (MongoDB). Finally, we present performance data and limitations of our approach along with planned future work. Copyright © 2015 John Wiley & Sons, Ltd.
Path and trajectory diversity: Theory and algorithms (2008)

We present heuristic algorithms for pruning large sets of candidate paths or trajectories down to smaller subsets that maintain desirable characteristics in terms of overall reachability and path length. Consider the example of a set of candidate paths in an environment that is the result of a forward search tree built over a set of actions or behaviors. The tree is precomputed and stored in memory to be used online to compute collision-free paths from the root of the tree to a particular goal node. In general, such a set of paths may be quite large, growing exponentially in the depth of the search tree. In practice, however, many of these paths may be close together and could be pruned without a loss to the overall problem of path-finding. The best such pruning for a given resulting tree size is the one that maximizes path diversity, which is quantified as the probability of the survival of paths, averaged over all possible obstacle environments. We formalize this notion and provide formulas for computing it exactly. We also present experimental results for two approximate algorithms for path set reduction that are efficient and yield desirable properties in terms of overall path diversity. The exact formulas and approximate algorithms generalize to the computation and maximization of spatio-temporal diversity for trajectories.
Digital micrography (2011)

We present an algorithm for creating digital micrography images, or micrograms, a special type of calligrams created from minuscule text. These attractive text-art works successfully combine beautiful images with readable meaningful text. Traditional micrograms are created by highly skilled artists and involve a huge amount of tedious manual work. We aim to simplify this process by providing a computerized digital micrography design tool. The main challenge in creating digital micrograms is designing textual layouts that simultaneously convey the input image, are readable and appealing. To generate such layout we use the streamlines of singularity free, low curvature, smooth vector fields, especially designed for our needs. The vector fields are computed using a new approach which controls field properties via a priori boundary condition design that balances the different requirements we aim to satisfy. The optimal boundary conditions are computed using a graph-cut approach balancing local and global design considerations. The generated layouts are further processed to obtain the final micrograms. Our method automatically generates engaging, readable micrograms starting from a vector image and an input text while providing a variety of optional high-level controls to the user.
Rationale and design of ASTEROID 2, a randomized, placebo- and active comparator-controlled study to assess the efficacy and safety of vilaprisan in patients with uterine fibroids (2017)

The placebo- and active comparator-controlled trial ASTEROID 2 is the first study to evaluate systematically the efficacy and safety of different treatment regimens of PRMs in women with UFs. The findings of this study will direct the planning of future clinical trials of vilaprisan.
Recent advances in nanodisc technology for membrane protein studies (2012–2017) (2017)

Historically, the main barrier to membrane protein investigations has been the tendency of membrane proteins to aggregate (due to their hydrophobic nature), in aqueous solution as well as on surfaces. The introduction of biomembrane mimetics has since stimulated momentum in the field. One such mimetic, the nanodisc (ND) system, has proved to be an exceptional system for solubilizing membrane proteins. Herein, we critically evaluate the advantages and imperfections of employing nanodiscs in biophysical and biochemical studies. Specifically, we examine the techniques that have been modified to study membrane proteins in nanodiscs. Techniques discussed here include fluorescence microscopy, solution-state/solid-state nuclear magnetic resonance, electron microscopy, small-angle X-ray scattering, and several mass spectroscopy methods. Newer techniques such as SPR, charge-sensitive optical detection, and scintillation proximity assays are also reviewed. Lastly, we cover how nanodiscs are advancing nanotechnology through nanoplasmonic biosensing, lipoprotein-nanoplatelets, and sortase-mediated labeling of nanodiscs.
Overcoming the Low Driving Force in Forming Depolymerizable Polymers through Monomer Isomerization (2021)

While depolymerizable polymers have been intensely pursued as a potential solution to address the challenges in polymer sustainability, most depolymerization systems are characterized by a low driving force in polymerization, which poses difficulties for accessing diverse functionalities and architectures of polymers. Here, we address this challenge by using a cyclooctene-based depolymerization system, in which the cis-to-trans alkene isomerization significantly increases the ring strain energy to enable living ring-opening metathesis polymerization at monomer concentrations ≥0.025 M. An additional trans-cyclobutane fused at the 5,6-position of the cyclooctene reduces the ring strain energy of cyclooctene, enabling the corresponding polymers to depolymerize into the cis-cyclooctene monomers. The use of excess triphenylphosphine was found to be essential to suppress secondary metathesis and depolymerization. The high-driving-force living polymerization of the trans-cyclobutane fused trans-cyclooctene system holds promise for developing chemically recyclable polymers of a wide variety of polymer architectures.
Mode partition noise characteristics in high-speed modulated laser diodes (1982)

This paper presents the theoretical and experimental results of a study on laser diode mode partition noise. Laser diode mode partition noise is evaluated by mode partition constants which indicate the degree of variance in longitudinal mode power. The relationship between the mode partition constants and laser diode characteristic parameters is clarified using rate equations. The mode partition constants for AlGaAs/GaAs and InGaAsP/InP double heterostructure laser diodes are measured experimentally and found to be independent of the structure, wavelength ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.8-1.6 \mu</tex> m), and bit-rate (400 Mbits/s-l.6 Gbits/s). The experimental and theoretical results show excellent agreement.
Optimization of the trochoidal electron monochromator (1980)

The trochoidal electron monochromator employs an axial magnetic field and a transverse electric field. Many aspects of its performance can be described by electron trajectory equations which include the voltage drop across the entrance aperture. A beam shear is predicted, which is a function of a parameter tanϑ. Optimum performance is achieved by matching the exit aperture to the sheared beam. tanϑ establishes a relationship between the field magnitudes and the dimensions of the monochromator. Estimates of appropriate values for these parameters can be made, with the final optimum values being determined by a combination of practical and empirical considerations. Finally, the use of the instrument as an energy analyzer is described.
Inhibition of ileal sodium-dependent bile acid transport by 2164U90. (1995)

Inhibition of the ileal bile acid active transport system, previously shown to be mechanism underlying the hypocholesterolemic activity of 2164U90 in rodents, was further characterized in isolated intestinal preparations from three species. 2164U90 inhibited sodium-dependent transport of taurocholic acid by Caco-2 cells and by monkey and human ileal brush border membrane vesicles in a concentration-dependent manner with IC50s of 7 microM, 5 microM, and 2 microM, respectively. In rat ileal brush border membrane vesicles, 2164U90 was a competitive inhibitor of sodium-dependent taurocholic acid uptake with an estimated Ki of 1.8 +/- 0.2 microM. In anesthetized rats, 5 microM 2164U90 placed in the isolated distal ileum with 3 mM [3H]taurocholic acid decreased ileal uptake, transport into the bile, and transport rate of taurocholic acid by 31-35%. Stereospecificity of inhibition by 2164U90 was demonstrated by the relative inactivity of three other possible stereoisomers in rat ileal sacs and brush border membrane vesicles. 2164U90 did not inhibit sodium-dependent glucose transport by monkey jejunal brush border membrane vesicles, indicating that 2164U90 may be specific for the bile acid transporter. These results suggest that 2164U90 is a potent, selective, stereospecific, competitive inhibitor of the sodium-dependent bile acid transporter in the ileal mucosal cell brush border membrane.
Skewed X‐chromosome inactivation is associated with primary but not secondary ovarian failure (2007)

Premature ovarian failure (POF) is the occurrence of menopause before the age of 40, and may present with either primary or secondary amenorrhea. Numerous cases of POF in women with X-chromosome deletions or translocations have been reported; thus, it is possible that smaller rearrangements undetectable by conventional cytogenetics may contribute to POF in some patients. In females with an abnormal X chromosome, cells with inactivation of the normal X may be selected against, causing skewed X-chromosome inactivation (XCI). We therefore assessed XCI by methylation sensitive restriction digestion and PCR amplification at the androgen receptor (AR) locus, in 4 primary and 55 secondary POF patients and 109 control women. In samples heterozygous at AR and therefore informative for the skewing assay, the frequency of skewed XCI among the women with secondary amenorrhea was identical to that in control women, with 4 out of 48 (8.3%) secondary ovarian failure patients and 8 out of 97 (8.2%) control women having > or =90% skewing. Notably, all three primary amenorrhea patients that were informative at AR had skewed XCI > or =90% (P = 0.001 vs. control women; Fisher's exact test). To investigate whether X-chromosome copy number alterations were responsible, DNA from selected patients with skewed XCI was examined by high resolution DNA microarray, however no potential regions of DNA addition or deletion were confirmed by FISH or PCR. X-chromosome abnormalities undetectable by array, or reduced follicular pool due to an early trisomic rescue event, may explain the skewed XCI observed in POF patients presenting with primary amenorrhea.
Fast matching pursuit with a multiscale dictionary of Gaussian chirps (2001)

We introduce a modified matching pursuit algorithm, called fast ridge pursuit, to approximate N-dimensional signals with M Gaussian chirps at a computational cost O(MN) instead of the expected O(MN/sup 2/logN). At each iteration of the pursuit, the best Gabor atom is first selected, and then, its scale and chirp rate are locally optimized so as to get a "good" chirp atom, i.e., one for which the correlation with the residual is locally maximized. A ridge theorem of the Gaussian chirp dictionary is proved, from which an estimate of the locally optimal scale and chirp is built. The procedure is restricted to a sub-dictionary of local maxima of the Gaussian Gabor dictionary to accelerate the pursuit further. The efficiency and speed of the method is demonstrated on a sound signal.