gebhart/patrepeval huggingface dataset:
Inhibition of activation of nuclear factor kappaB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root. (1999)

Effects of higenamine on nitric oxide (NO) production and inducible NO synthase (iNOS) mRNA expression (RAW 264.7 cells), on vascular reactivity in vitro and in vivo (rats), and on survival rates (mice) and serum nitrite/nitrate levels (rats) were investigated by using last lipopolysaccharide (LPS) plus interferon (IFN)-gamma. Higenamine concentration-dependently inhibited NO production and inducible NO synthase mRNA in RAW 264.7 cells, in which the IC(50) was 53 microM. Higenamine (10 mg/kg i.p.) administered 90 min before LPS (5 mg/kg i.v.) prevented not only LPS-induced hypotension but also pressor response to norepinephrine (1 microgram/kg) in rats. Incubation of thoracic aorta with LPS (300 ng/ml) for 8 h in vitro resulted in suppression of the vasoconstrictor effects to phenylephrine, which was prevented by coincubation with higenamine. The survival rate to endotoxin in mice was significantly (P <.01) increased by the presence of higenamine in the LPS-treated group up to 48 h. Serum nitrite/nitrate levels were significantly (P <.05) reduced by higenamine in LPS-treated rats. Finally, higenamine inhibited the activation of nuclear factor kappaB in RAW 264.7 cells due to LPS + IFN-gamma by mobility shift assays. Taken together, these data strongly suggest that higenamine inhibits iNOS expression by inhibiting nuclear factor kappaB activation by LPS + IFN-gamma, which may be beneficial in inflammatory diseases in which enhanced formation of NO is the main causative factor. Furthermore, due to positive inotropic action, higenamine may be more effective in a condition where myocardial contractility is likely to depress, such as in septic shock and/or endotoxin-induced inflammatory disorders.
An insight into gingival depigmentation techniques: The pros and cons. (2018)

Pigmentation of gingiva not just has an impact on esthetics but also creates psychological negativity. Although a wide array of depigmentation techniques are available to manage this condition, there is a scarcity of literature that guides clinicians to choose the most appropriate technique. Hence, the aim of this review is to evaluate the available depigmentation therapeutic modalities with an emphasis on their merits and demerits. The databases of MEDLINE and Cochrane databases of systematic reviews were searched to collect relevant scientific literature. Cryosurgery followed by lasers has been reported to be the superior techniques with better esthetic results and low rate of recurrence. However, further randomized controlled longitudinal studies are warranted to elaborate the efficiency and effectiveness of available techniques.
The Future Internet of Things: Secure, Efficient, and Model-Based (2017)

The Internet of Things’ (IoT’s) rapid growth is constrained by resource use and fears about privacy and security. A solution jointly addressing security, efficiency, privacy, and scalability is needed to support continued expansion. We propose a solution modeled on human use of context and cognition, leveraging cloud resources to facilitate IoT on constrained devices. We present an architecture applying process knowledge to provide security through abstraction and privacy through remote data fusion. We outline five architectural elements and consider the key concepts of the “data proxy” and the “cognitive layer.” The data proxy uses system models to digitally mirror objects with minimal input data, while the cognitive layer applies these models to monitor the system’s evolution and to simulate the impact of commands prior to execution. The data proxy allows a system’s sensors to be sampled to meet a specified quality of data target with minimal resource use. The efficiency improvement of this architecture is shown with an example vehicle tracking application. Finally, we consider future opportunities for this architecture to reduce technical, economic, and sentiment barriers to the adoption of the IoT.
Hemodynamic and Metabolic Efficacy of Dopamine Versus Norepinephrine in a Brain-Dead Swine Model (2008)

We tested the hypothesis that hepatosplanchnic and systemic hemodynamics are improved with equi-effective doses of dopamine (DA) versus norepinephrine (NE) in a brain-dead swine model. Pigs (n = 18) were anesthetized and ventilated. Brain death was induced by epidural balloon inflation, hypoventilation, and hypoxia. After 30 minutes, mechanical ventilation was restored without anesthesia. During 60 and until 480 minutes, half received DA (10 microg/kg/minute) and half received NE (0.1 microg/kg/minute) titrated to a mean arterial pressure (MAP) > 60 mm Hg with supplemental fluid to maintain a central venous pressure > 8 mm Hg. Hemodynamics, hepatic laser Doppler blood flow, and hepatic and gastric tissue oxygenation with near-infrared spectroscopy were continuously monitored. Serial blood samples were analyzed for blood gases and electrolytes, coagulation changes, and serum chemistries. Balloon inflation caused brain death and autonomic storm, and 8 of 18 were nonsurvivors. After 30 minutes, the MAP, mixed venous O(2) saturation, and partial pressure of arterial oxygen values decreased to 37 +/- 2 mm Hg, 38 +/- 4, and 49 +/- 8 mm Hg, respectively. Serum lactate increased to 5.4 +/- 0.7 mM. Among survivors (n = 10), MAP stabilized with either pressor. Urine output was maintained (>1 mL/kg/hour), but creatinine increased >30% with respect to the baseline. Tachyphylaxis developed with NE but not with DA (P < 0.05). Cardiac index was higher with DA versus NE (P < 0.05). There were no differences in stroke volume, metabolic indices, or liver blood flow. Liver tissue O(2) was higher with DA versus NE at 8 hours (P < 0.05). Coagulation tests and liver enzymes were similar with NE versus DA (P > 0.05). In conclusion, after brain death, cardiac index and hepatic oxygenation were significantly improved with equi-effective doses of DA versus NE.
Mullite—Alumina Composites by Extrusion (1992)

The rheological properties of a paste containing chopped alumina fiber and particulate silica suspended in a gelled boehmite liquid phase have been evaluated using a physically based extrusion model. When sintered, the paste formed a mullite‐alumina fiber composite. Extrudates with fiber volumes up to 30% in the sintered product were prepared. During extrusion, the pressure drop was largely independent of extrudate velocity, fiber length, and the fiber concentration. All pastes showed significant yield behavior leading to good postextrusion shape retention. For any given fiber length, it was shown that there exists a critical volume fraction above which fiber‐fiber interactions are so great that both yield and wall shear stresses increase. At these high concentrations of fiber, inhomogeneities also increase. Up to the critical volume fraction, dispersed wet fibers produced lower extrusion parameters than when dry fibers were used as the starting material. The observed behavior is explained in terms of low viscosity liquid formation above the yield point of the boehmite gel.
Peritoneal Injury by Methylglyoxal in Peritoneal Dialysis (2006)

MGO induced not only peritoneal injury but also abdominal cocoon formation in vivo. The decline of peritoneal function may result from reconstitution of microvessel basement membrane or neovascularization.
Mycobacterial phagosome maturation, rab proteins, and intracellular trafficking (1997)

One of the most prominent features of pathogenic mycobacteria, which include the potent human pathogens Mycobacterium tuberculosis and Mycobacterium leprae and their opportunistic relatives Mycobacterium avium and Mycobacterium marinum, is their ability to survive and multiply in phagosomes of mononuclear phagocytic cells. The phagocytosed mycobacteria reside in a vacuolar compartment which is exempted from maturation into the phagolysosome. Recently, the arrest of the maturation of phagosomes containing M. tuberculosis complex organisms (Mycobacterium bovis BCG) has been linked to the accumulation on the phagosomal membrane of the small GTP binding protein rab5, specific for the control of fusion within the early endosomal compartment. Furthermore, M. bovis BCG phagosome is devoid of rab7, a rab protein associated with the late endosome. The selective accumulation of rab5 and exclusion of rab7 defines the check point that has been compromised in mycobacterial phagosome maturation. Here we summarize these observations and relates them to other phenomena in the area of membrane and protein trafficking with the emphasis on phagosomes containing intracellular pathogens.
Coupling between microstrip lines with finite width ground plane embedded in thin-film circuits (2005)

Three-dimensional (3-D) interconnects built upon multiple layers of polyimide are required for constructing 3-D circuits on CMOS (low resistivity) Si wafers, GaAs, and ceramic substrates. Thin-film microstrip lines (TFMS) with finite-width ground planes embedded in the polyimide are often used. However, the closely spaced TFMS fines are susceptible to high levels of coupling, which degrades the circuit performance. In this paper, finite-difference time domain (FDTD) analysis and experimental measurements are used to demonstrate that the ground planes must be connected by via holes to reduce coupling in both the forward and backward directions. Furthermore, it is shown that coupled microstrip lines establish a slotline type mode between the two ground planes and a dielectric waveguide type mode, and that the connected via holes recommended here eliminate these two modes.
Classically-Boosted Quantum Optimization Algorithm (2022)

Considerable effort has been made recently in the development of heuristic quantum algorithms for solving combinatorial optimization problems. Meanwhile, these problems have been studied extensively in classical computing for decades. In this paper, we explore a natural approach to leveraging existing classical techniques to enhance quantum optimization. Specifically, we run a classical algorithm to find an approximate solution and then use a quantum circuit to search its "neighborhood" for higher-quality solutions. We propose the Classically-Boosted Quantum Optimization Algorithm (CBQOA) that is based on this idea and can solve a wide range of combinatorial optimization problems, including all unconstrained problems and many important constrained problems such as Max Bisection, Maximum Independent Set, Minimum Vertex Cover, Portfolio Optimization, Traveling Salesperson and so on. A crucial component of this algorithm is an efficiently-implementable continuous-time quantum walk (CTQW) on a properly-constructed graph that connects the feasible solutions. CBQOA utilizes this CTQW and the output of an efficient classical procedure to create a suitable superposition of the feasible solutions which is then processed in certain way. This algorithm has the merits that it solves constrained problems without modifying their cost functions, confines the evolution of the quantum state to the feasible subspace, and does not rely on efficient indexing of the feasible solutions. We demonstrate the applications of CBQOA to Max 3SAT and Max Bisection, and provide empirical evidence that it outperforms previous approaches on these problems.
Decentralized network connection preemption algorithms (1998)

Connection preemption provides available and reliable services to high-priority connections when a network is heavily loaded and connection request arrival patterns are unknown, or when the network experiences link or node failures. Coupled with the capability to reroute connections (preempted due to failure or preemption), connection preemption allows a high quality of service to be provided to network connections and bandwidth to be used more efficiently. The main contributions of this paper are the following. It presents a comprehensive simulation study of preemption in a general connection-oriented network setting. Our simulation study also provides useful insights into connection preemption and network dimensioning problems in order to achieve a desired level of network availability. Based on the observations made in this study, we designed two connection preemption selection algorithms that operate in a decentralized/distributed network where individual link managers run the algorithm for connection preemption selection on their outgoing links. The first algorithm optimizes the criteria of (i) the bandwidth to be preempted, (ii) the priority of connections to be preempted, and (iii) the number of connections to be preempted, in that order, and has exponential complexity. The second algorithm optimizes the criteria of (i) the number of connections to be preempted, (ii) the bandwidth to be preempted, and (iii) the priority of connections to be preempted, in that order, and has polynomial complexity. From a comparison study of these two algorithms we conclude that the polynomial algorithm is almost as good as the exponential algorithm in terms of overall network performance.
Organisational Decision Making and Industrial Marketing (1985)

Provides a new paradigm capable of integrating and developing research, which, it proposes, gives a better understanding of industrial buyer behaviours. Concludes that the model provided can be used by practitioners as a basis on which to form their marketing message, but not its style of delivery or specific direction.
Strong Mobile Authentication (2005)

Our main contribution is a protocol that provides strong mobile authentication with non-repudiation using SMS messages. For ensuring these properties, governmentally controlled PKI, and SIM cards with electronic identity application are used. Moreover, our protocol provides confidentiality and integrity of transferred content. An application that implements this protocol was developed and tested in a partly simulated environment. Furthermore, we developed a protocol for mobile payment for vending machines. In comparison to current systems, this protocol contains several enhancements in security, usability and cost both from the client as well as from the service provider point of view.
The Trim Coils for the Wendelstein 7-X Magnet System (2011)

The magnet system of the fusion experiment Wendelstein 7-X (W7-X) consists of superconducting as well as normal conducting coils. 50 non planar superconducting coils are forming the main field, 20 planar superconducting coils allow varying the shape of the plasma. Inside of the plasma vessel 10 normal conducting control coils will be placed to modify the strike points of the plasma at the divertor. In addition a set of five normal conducting trim coils has been designed to allow the correction of error fields and to increase the experimental flexibility. The coils will be placed at the outer surface of the outer vessel of W7-X. Four out of five coils have identical size and shape. They have dimensions of 3.5 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\times$</tex></formula> 3.3 meters with 48 turns and will be operated with currents of up to 1.8 kA. The other coil type has a smaller size of 2.8 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\times$</tex></formula> 2.2 meters, but a higher number of turns and a higher operating current of 1.95 kA. Both types of trim coils will be made of square copper hollow profile with an integrated cooling channel. Five independent power supplies will be used to energize the coils. The present concept is based on four-quadrant power supplies. The control system will allow the local control as well as the remote control of the five power supplies from an external control room.
Different requirements for membrane fusion mediated by the envelopes of human immunodeficiency virus types 1 and 2 (1993)

CD4+ cells derived from the human cell lines U87MG and SCL1 cannot be infected by human immunodeficiency virus type 1 (HIV-1) or fuse with cells expressing the HIV-1 envelope. This block was complemented in heterokaryons with HeLa cells and probably reflects the absence of cellular factors necessary for membrane fusion. Since U87MG cells expressing CD4 are permissive to HIV-2, distinct cellular factors could be required for fusion mediated by two related human retroviruses.
Mask shot count reduction strategies in the OPC flow (2008)

Increasing pattern density and the higher complexity of advanced OPC and RET technologies have lead to an explosion in mask data volume. This increased data volume leads to increased mask write times, inspection times, and costs. In the past, several techniques for reducing the mask shot count have been proposed, including OPC fragment alignment, jog alignment, jog smoothing, and design intent-aware layout fragmentation among others. This paper will explore the tradeoffs between mask shot count and simulated print quality for various shot count reduction strategies.
Adaptive direct manipulation (2002)

A description is presented of ADM (adaptive direct manipulation), a prototype graphical user interface (GUI) system which is adaptive to user performance. ADM allows users to perform a set of tasks via direct manipulation of graphical buttons presented within the display space of a computer touch screen. The presentation and management of these buttons dynamically adapt to the button selection behavior of the current user. The goal of this work was to understand and develop a working software system which could correctly integrate the necessary knowledge to support a given set of operations and effectively adapt its GUI to the behavior and performance of a user.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development and Validation of a Deep Learning-Based Model Using Computed Tomography Imaging for Predicting Disease Severity of Coronavirus Disease 2019 (2020)

Our deep learning-based model can accurately predict disease severity as well as disease progression in COVID-19 patients using CT imaging, offering promise for guiding clinical treatment.
Integration of the Extranuclear and Nuclear Actions of Estrogen (2005)

Abstract Estrogen receptors (ERs) are localized to many sites within the cell, potentially contributing to overall estrogen action. In the nucleus, estrogen mainly modulates gene transcription, and the resulting protein products determine the cell biological actions of the sex steroid. In addition, a small pool of ERs localize to the plasma membrane and signal mainly though coupling, directly or indirectly, to G proteins. In response to steroid, signal transduction modulates both nontranscriptional and transcriptional events and impacts both the rapid and more prolonged actions of estrogen. Cross-talk from membrane-localized ERs to nuclear ERs can be mediated through growth factor receptor tyrosine kinases, such as epidermal growth factor receptor and IGF-I receptor. Growth factor receptors enact signal transduction to kinases such as ERK and phosphatidylinositol 3-kinase that phosphorylate and activate nuclear ERs, and this can also occur in the absence of sex steroid. A complex relationship between the membrane and nuclear effects of estrogen also involves membrane-initiated phosphorylation of coactivators, recruiting these proteins to the nuclear transcriptosome. Finally, large pools of cytoplasmic ERs exist, and some are localized to mitochondria. The integration of sex steroid effects at distinct cellular locations of its receptor leads to important cellular physiological outcomes and are manifest in both reproductive and nonreproductive organs.
Possible Plasmid Nature of the Determinant for Production of the Antibiotic Nisin in Some Strains of Streptococcus lactis (1975)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Complex Assembly Behavior During the Encapsulation of Green Fluorescent Protein Analogs in Virus Derived Protein Capsules (2010)

Enzymes encapsulated in nanocontainers are a better model of the conditions inside a living cell than free enzymes in solution. In a first step toward the encapsulation of multiple enzymes inside the cowpea chlorotic mottle virus (CCMV) capsid, enhanced green fluorescent protein (EGFP) was attached to CCMV capsid proteins. The capsid protein-EGFP complex was then co-assembled with wild-type capsid protein (wt CP) in various ratios. At higher complex to wt CP ratios, the number of EGFP per capsid decreased instead of leveling off. We propose that this unexpected behavior is caused by pH-induced disassembly of the capsid protein-EGFP complex as well as by concentration and ratio dependent dimerization of the complex, making it partially unavailable for incorporation into the capsid.
The prevalence of red cell antibodies in pregnancy correlated to the outcome of the newborn: (1995)

Few antibodies to blood group antigens other than those in the Rhesus system were found to cause severe HDN. Antibodies that are generally considered non-significant did not cause HDN in this study. All antibodies that induced HDN were detected in time so that adequate measures could be taken to reduce the effects in the newborn. The antenatal screening and management programme currently in use is considered to be reliable.
Optimization of an Albumin-Binding Prodrug of Doxorubicin That Is Cleaved by Prostate-Specific Antigen (2010)

We have developed a novel albumin-binding prodrug of doxorubicin that incorporates p-aminobenzyloxycarbonyl (PABC) as a 1,6 self-immolative spacer in addition to the heptapeptide, Arg-Ser-Ser-Tyr-Tyr-Ser-Leu, as a substrate for the prostate-specific antigen (PSA) that is overexpressed in prostate carcinoma and represents a molecular target for selectively releasing an anticancer agent from a prodrug formulation. The prodrug exhibited good water solubility and was bound rapidly to the cysteine-34 position of human serum albumin. Incubation studies with PSA demonstrated that the albumin-bound form of the prodrug was cleaved rapidly at the P1-P1' scissile bond, releasing H-Ser-Leu-PABC-DOXO, which was further degraded to release doxorubicin as a final cleavage product within a few hours in prostate tumor tissue homogenates as well as in PSA-positive LNCaP LN cell lysates. Moreover, our prodrug exhibited antiproliferative activity in a low micromolar range against a PSA-expressing prostate cancer cell line (LNCaP).
GaInAsSb-AlGaAsSb tapered lasers emitting at 2 mu m (1993)

Tapered oscillators fabricated from GaInAsSb-AlGaAsSb quantum-well structure are reported for the first time. The quantum-well laser structure, grown by molecular beam epitaxy, has broad-stripe pulsed threshold current densities as low as 330 A/cm/sup 2/ at room temperature. One tapered laser emitting at 2.02 mu m has exhibited continuous wave (CW) output power up to 750 mW, with power in the near-diffraction-limited central lobe as high as 200 mW.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>