gebhart/patrepeval huggingface dataset:
Development of a method for screening short-lived proteins using green fluorescent protein (2004)

We have developed a screening technology for the identification of short-lived proteins. A green fluorescent protein (GFP)-fusion cDNA library was generated for monitoring degradation kinetics. Cells expressing a subset of the GFP-cDNA expression library were screened to recover those in which the fluorescence signal diminished rapidly when protein synthesis was inhibited. Thirty clones that met the screening criteria were characterized individually. Twenty-three (73%) proved to have a half-life of 4 hours or less.
Kinetic and dimensional optimization for a tendon-driven gripper (2013)

We design, optimize and demonstrate the behavior of a tendon-driven robotic gripper performing fingertip and enveloping grasps. The gripper consists of two fingers, each with two links, and is actuated using a single active tendon. During unobstructed closing, the distal links remain parallel, creating exact fingertip grasps. Conversely, if the proximal links are stopped by contact with an object, the distal links start flexing, creating a stable enveloping grasp. We optimize the route of the active tendon and the parameters of the springs providing passive extension forces in order to achieve this behavior. We show how an additional passive tendon can be used as a constraint preventing the gripper from entering undesirable parts of the joint workspace. Finally, we introduce a method for optimizing the dimensions of the links in order to achieve enveloping grasps of a large range of objects, and apply it to a set of common household objects.
Security Analysis of Multimedia Encryption Schemes Based on Multiple Huffman Table (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This letter addresses the security issues of the multimedia encryption schemes using multiple Huffman table (MHT). A known-plaintext attack is presented to show that the MHTs used for encryption should be carefully selected to avoid the weak keys problem. We then propose chosen-plaintext attacks on the basic MHT algorithm as well as the enhanced scheme with random bit insertion. In addition, we suggest two empirical criteria for Huffman table selection, based on which we can simplify the stream cipher integrated scheme, while ensuring a high level of security. </para>
Proposal for tactile sense presentation that combines electrical and mechanical stimulus (2007)

This study proposes a combination of electrical and mechanical stimulation as a foundational method to realize a tactile display with a high temporal and spatial resolution. We further confirm the interaction between the electrical and mechanical stimulations. The interaction (1) lowers tactile threshold and (2) reduces the so-called "electrical" sensation. The results of this study may resolve certain practical difficulties with regard to electro-tactile displays
Photoplethysmograph fingernail sensors for measuring finger forces without haptic obstruction (2001)

A new type of touch sensor for detecting contact pressure at human fingertips is presented. This new sensor allows the fingers to directly contact the environment without obstructing the human's natural haptic senses. The finger touch force is detected by measuring changes in the coloration of the fingernail; hence the sensor is mounted on the fingernail rather than on the fingertip. Specifically, the fingernail is instrumented with miniature light emitting diodes (LEDs) and photodetectors in order to measure changes in the reflection intensity when the fingertip is pressed against a surface. The changes in intensity are then used to determine changes in the blood volume under the fingernail, a technique termed "reflectance photoplethysmography". A hemodynamic model is used to investigate the dynamics of the blood volume at two locations under the fingernail. A miniaturized prototype nail sensor is designed, built, and tested. The theoretical analysis is verified through experiment and simulation.
Preparation of fibers with nanoscaled morphologies: Electrospinning of polymer blends (2001)

Abstract The aim was to prepare fibers with diameters below the micrometer range characterized by specific bulk morphologies and surface topologies. Such materials are of interest for various applications including reinforcement, sensors or filtration as well as the formation of functional tubes by the use of fiber templates. We were able to manufacture highly structured submicrometer fibers by electrospinning from ternary solutions using polylactide (PLA) and polyvinylpyrrolidone (PVP) as polymer model components. Co‐continuous phase morphologies resulted from phase separation processes taking place during fiber formation. In a subsequent step, specific surface topologies or fine pores were generated by selective removal of one of the components.
Real time head pose tracking from multiple cameras with a generic model (2010)

We present a robust approach to real-time 3D head pose tracking using multiple cameras with unknown camera placements. Many important applications do not want prior multi-camera calibration. We exploit a generic face model to overcome the difficulties due to the lack of prior knowledge of camera placement and the severe head appearance difference across cameras. We propose a fast drift-free solution based on feature point tracking using reference frames of high confidence over the temporal and spatial domains. Our algorithm tracks feature points from Harris feature detector, but not necessarily points of face landmarks. The relative camera placement is refined progressively at the same time as the user's head pose is resolved. Compared to single camera tracking, the use of multiple cameras increases the reliability of tracking by covering a wider range of poses as well as providing more accurate head pose estimation. We have tested the algorithm on many subjects in a variety of environments. A live demonstration will be shown at the conference.
Efficient face detection by a cascaded support–vector machine expansion (2004)

We describe a fast system for the detection and localization of human faces in images using a nonlinear ‘support–vector machine’. We approximate the decision surface in terms of a reduced set of expansion vectors and propose a cascaded evaluation which has the property that the full support–vector expansion is only evaluated on the face–like parts of the image, while the largest part of typical images is classified using a single expansion vector (a simpler and more efficient classifier). As a result, only three reduced–set vectors are used, on average, to classify an image patch. Hence, the cascaded evaluation, presented in this paper, offers a thirtyfold speed–up over an evaluation using the full set of reduced–set vectors, which is itself already thirty times faster than classification using all the support vectors.
Magnetic nanoparticle temperature estimation: The improvement of measurement speed (2015)

The noninvasive nanoscale thermometer with high measurement speed will become a very promising research. The speed of the temperature estimation using the model of AC magnetization spectrum is limited by the frequency of AC applied magnetic field [1-3]. You may need MHz magnetic field to get a faster temperature measuring or even higher frequency, and it would require a huge power to support the magnetic field and maintain the strength. So it is very difficult to guarantee the stability of the magnetic field. Instead of using AC magnetic field, DC magnetic field has a wider room for improvement of measurement speed.
Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication (2004)

Marek's disease virus (MDV) causes an acute lymphoproliferative disease in chickens, resulting in T cell lymphomas in visceral organs and peripheral nerves. Earlier studies have determined that the repeat regions of oncogenic serotype 1 MDV encode a basic leucine zipper protein, Meq, which structurally resembles the Jun/Fos family of transcriptional activators. Meq is consistently expressed in MDV-induced tumor cells and has been suggested as the MDV-associated oncogene. To study the function of Meq, we have generated an rMd5DeltaMeq virus by deleting both copies of the meq gene from the genome of a very virulent strain of MDV. Growth curves in cultured fibroblasts indicated that Meq is dispensable for in vitro virus replication. In vivo replication in lymphoid organs and feather follicular epithelium was also not impaired, suggesting that Meq is dispensable for lytic infection in chickens. Reactivation of the rMd5DeltaMeq virus from peripheral blood lymphocytes was reduced, suggesting that Meq is involved but not essential for latency. Pathogenesis experiments showed that the rMd5DeltaMeq virus was fully attenuated in chickens because none of the infected chickens developed Marek's disease-associated lymphomas, suggesting that Meq is involved in lymphocyte transformation. A revertant virus that restored the expression of the meq gene, showed properties similar to those of the parental virus, confirming that Meq is involved in transformation but not in lytic replication in chickens.
Enabling ammonia-borane: co-oligomerizaiton of ammonia-borane and amine-boranes yield liquid products (2014)

Slurries of ammonia-borane and functionalized amine-boranes form liquid spent fuels after heating in batch or flow-thru reactors.
Vacuum-deposited, nonpolymeric flexible organic light-emitting devices (1997)

We demonstrate mechanically flexible, organic light-emitting devices (OLED's) based on the nonpolymetric thin-film materials tris-(8-hydroxyquinoline) aluminum (Alq(3)) and N, N(?) -diphenyl- N, N(?) -bis(3-methylphenyl)1- 1(?) biphenyl-4, 4(?) diamine (TPD). The single heterostructure is vacuum deposited upon a transparent, lightweight, thin plastic substrate precoated with a transparent, conducting indium tin oxide thin film. The flexible OLED performance is comparable with that of conventional OLED's deposited upon glass substrates and does not deteriorate after repeated bending. The large-area (~1 - cm>(2)) devices can be bent without failure even after a permanent fold occurs if they are on the convex substrate surface or over a bend radius of ~0.5>cm if they are on the concave surface. Such devices are useful for ultralightweight, flexible, and comfortable full-color flat panel displays.
Effect of Steady and Unsteady Slot Blowing on a Vertical Axis Wind Turbine (2010)

An analysis of vertical axis wind turbines (VAWTs), subjected to flow control by means of steady and pulsed slot blowing, was performed. The analysis was based on blade element theory that included experimental data acquired on a NACA 0012 airfoil. Two methods of control were considered: constant local blade momentum coefficient (oscillatory jet) and constant turbine momentum coefficient (steady jet). The net turbine power output was calculated by accounting for the pumping power required to drive the slot blowing system. The results show great potential for flow control by jet blowing using all methods and approaches. The best net performance increase, namely a factor of 3 in annual energy production, was achieved by means of pulsed blowing using a constant blade momentum coefficient, deployed on both sides of the blade. The simplest of all the methods, namely constant turbine momentum coefficient via a single slot, resulted in 60% increase in annual energy production.
ChemInform Abstract: Asymmetric Hydrogenation of Ketones with H<sub>2</sub> and Ruthenium Catalysts Containing Chiral Tetradentate S<sub>2</sub>N<sub>2</sub> Ligands. (2014)

Abstract The first phosphorus‐free, air‐ and moisture‐tolerant Ruthenium‐catalyzed asymmetric hydrogenation of methylketones and cyclic ketones, as well as aldehydes using hydrogen is presented.
Synthesis of blood serum thymic factor and its analogs (1986)

The blood serum thymic factor (FTS) and its two analogs (desGlp 1 )-FTS and (Gln 1 )-FTS were synthesized by a novel procedure. The biological activity of these compounds was assayed by the E-rosette test. The activity of (desGlp 1 )-FTS is decreased and (Gln 1 )-FTS shows an inhibitory effect.
Charge Transport in Solid State Molecular Junctions (2013)

Abstract not Available.
High-Pressure Helium-3 Scintillation Position-Sensitive Detector of Thermal Neutrons (2002)

Abstract : The objective of this study is to demonstrate the feasibility of constructing a compact neutron detector that is sensitive to thermal and epithermal neutrons and has high rejection efficiency relative to gamma-ray background. A two-channel high-pressure 3He scintillation detector is considered for the detection of neutrons in coincidence mode. The detector consists of two large avalanche photodiodes viewing a gas volume filled with pressurized 3He. Experiments with the detector demonstrate high efficiency to neutrons and high rejection ability to gamma rays. Position sensitivity of the detector to thermal neutrons is demonstrated and confirmed with computer simulations.
Comparative study between electrically ground and electrically floating PET inserts using MRI built-in RF coil at 3 T (2018)

A modular radiofrequency (RF) shielded PET insert, electrically floating from the RF ground, enables the RF field from outside to penetrate through the inter-modular gaps to the imaging region (ROI) with less attenuation compared to the electrically grounded PET insert. In this study, we developed an electrically floating PET insert by implementing conventional electric data transmission and power source cables and, performed a comparison with the same PET ring as a grounded PET insert inside a 3 T MRI system. An existing electrical data transmission capable RF shielded PET detector ring is modified to perform the study. The PET inserts, with the inner diameter of 240-mm, had eight RF shielded PET detector modules with intermodular gap of 5 mm. Here the term ground PET is used to mean that both the RF shields of cables and the PET detector modules are together connected to the RF ground. On the other hand, the term floating PET is used to mean that the RF shield boxes of PET detector modules kept electrically isolated from the cable shield that remained connected to RF ground. The MRI system built-in body RF coil (700-mm in diameter) is used both as RF transmitter and receiver. A homogeneous phantom study revealed an approximate 10% and 20% reduction in mean RF field attenuation for the front 125 mm axial-FOV of respectively floating and ground PET insert. Compared to the front of PET insert, an approximate 20% and 40% field attenuation was seen for an imaging region close to the PET insert cable-end. However, RF field homogeneity for both the front and center of the PET insert was comparable to the MRI-only values.
Application of harmonics detection to the measurement of mode field radius in single-mode optical fibers (1986)

In this paper, new techniques for the easy implementation of the measurement of the mode field radius in single-mode optical fibers are discussed. All of them are based on a dynamical filtering of the fiber output radiation and on a subsequent detection of suitable harmonic components. The capabilities of these procedures are considered, showing typical experimental results.
The Acrylonitrile Analog, VJ-289 Ablates Acute Myelogenous Leukemia Blast, Progenitor and Stem Cell Populations by Inducing Tubulin Acetylation and Caspase Activation (2011)

Abstract Abstract 2496 Combretastatin A-4, a derivative of combretastatin, a natural product of the South African tree Combretum caffrum, has been reported to have anti-angiogenic and anti-tubulin effects in different cancer cell lines. We synthesized 48 novel combretastatin analogs to assess anti-leukemia activity in a panel of 12 leukemia cell lines. We identified an analog, VJ-289 [(Z)-3-(1H-indol-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile] with robust anti-leukemic activity. VJ-289 showed a dose-dependent toxicity to most of the leukemic cell lines tested. The average LD50 for the 12 different leukemia cell lines was 132 nM (95% CI, 91.8–170.5). Specifically, MV4-11 cells demonstrated the most sensitivity to VJ-289 (LD50 = 66 nM), whereas THP-1 was the most resistant (LD50 = 227 nM). Furthermore, when the activity of VJ-289 was tested, five out of 14 primary AML samples demonstrated resistance to VJ-289 with an LD50 > 300nM. The average LD50 for the sensitive primary AML samples was 64.06 nM (95% CI, 35.36–92.76; N=9). Most importantly, normal CD34+ cord blood cells were significantly less affected by VJ-289 (LD50 > 500 nM). Furthermore, VJ-289 was capable of eliminating AML progenitor/stem cells as determined by phenotypic analysis in 15 primary AML samples, colonies forming ability (N=6) and xenotransplant assays (N=6). Overall, we observed a 90.3% decrease in colony formation after treatment with 150 nM VJ-289 relative to untreated control. In contrast, VJ-289 had less impact on colony forming ability of normal hematopoietic stem/progenitor cells from cord blood cells (66.1% decrease relative to untreated; p=0.013). To investigate the role of VJ-289 in leukemic cell apoptosis, various cell survival signaling pathways were examined. Western blotting and intracellular staining/flow cytometry data showed that caspases, including caspase 3 and 8, were activated alongside the cleavage of PARP in a dose-dependent manner. Caspase activation was observed as early as 4 h after treatment with 100 nM VJ-289. PI3K/AKT, MAPK and NF-κB were decreased upon VJ-289 treatment. Moreover, the degradation of MCL1 and the cleavage of Bcl2, two anti-apoptotic Bcl2 family members, were decreased by VJ-289 in a dose- and time-dependent manner. Interestingly, the acetylation of α-tubulin, which is critical for microtubule stabilization, and is involved in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling, was transiently induced by VJ-289 within 2 hours, and was inhibited dramatically after 4 hours. In summary, we have identified a combrestastatin A-4 analog, VJ-289, as a new anti-leukemia agent with the ability to ablate blast, progenitor and stem cell populations via induction of caspase activation and α-tubulin acetylation. Studies are underway to determine what modulates sensitivity to VJ-289 across AML specimens. Disclosures: No relevant conflicts of interest to declare.
Inhibin: a candidate gene for premature ovarian failure (2000)

Premature ovarian failure (POF) occurs in 1% of all women, and in 0.1% of women under the age of 30 years. The mechanisms that give rise to POF are largely unknown. Inhibin has a role in regulating the pituitary secretion of FSH, and is therefore a potential candidate gene for ovarian failure. Using single-stranded conformation polymorphism (SSCP) and DNA sequencing, DNA samples were screened from 43 women with POF for mutations in the three inhibin genes. Two variants were found: a 1032C-->T transition in the INHssA gene in one patient, and a 769G-->A transition in the INHalpha gene in three patients. The INHssA variant appears to be a polymorphism, as there was no change in the amino acid sequence of the gene product. The INHalpha variant resulted in a non-conservative amino acid change, with a substitution from alanine to threonine. This alanine is highly conserved across species, and has the potential to affect receptor binding. The INHalpha variant is significantly associated with POF (3/43 patients; 7%) compared with control samples (1/150 normal controls; 0.7%) (Fisher's exact test, P < 0.035). Further analysis of the inhibin gene in POF patients and matched controls will determine its role in the aetiology of POF.
Porous Semiconducting Gels and Aerogels from Chalcogenide Clusters. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Improved Magnesium/Manganese Dioxide Electrochemical Cell. (1988)

Abstract : The demand for improved energy storage systems has increased greatly with the evolution of new equipment requiring new and improved battery systems as a power source. Critical characteristics that power sources must accommodate are low cost, high energy density, light weight, and good storability. The present magnesium/manganese dioxide electrochemical system provides high energy density at low cost. A magnesium/manganese dioxide electrochemical cell that has been stored following partial usage is improved by increasing the cathode moisture content at the time of making the cell to reduce the self discharge and increase the operating capacity after the cell has been stored following partial usage.
Real-time programmable joint transform correlator (1985)

A real-time programmable joint transform correlator (PJTC) utilizing a magnetooptic device (MOD) with a liquid crystal light valve (LCLV) is presented. Object functions to be correlated are written into a light MOD with a programmable microcomputer as input signals. Real-time correlation takes place with a LCLV, as a square-law detector, with a coherent read out. Cross correlation between the input functions can be obtained through the inverse Fourier transform of the read-out coherent illumination. A brief discussion of the proposed PJTC and a few experimental results are provided.
Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading, Sustained Release, and Cellular Delivery of Therapeutical Proteins (2014)

A rationally designed two-step synthesis of silica vesicles is developed with the formation of vesicular structure in the first step and fine control over the entrance size by tuning the temperature in the second step. The silica vesicles have a uniform size of ≈50 nm with excellent cellular uptake performance. When the entrance size is equal to the wall thickness, silica vesicles after hydrophobic modification show the highest loading amount (563 mg/g) towards Ribonuclease A with a sustained release behavior. Consequently, the silica vesicles are excellent nano-carriers for cellular delivery applications of therapeutical biomolecules.
Design variants of the bearingless segment motor (2010)

Bearingless drives and magnetic bearings allow the construction of contactless, wearless and lubrication-free rotating systems. Utilizing a permanent magnet excited rotor disc permits the passive stabilization of three degrees of freedom (tilting and axial deflection) by reluctance forces. Hence, using these bearingless slice motors it becomes possible to design very compact magnetically suspended drive systems. The bearingless segment motor is a subtype of the bearingless slice motor, where the stator consists of single elements. As a matter of fact, all these stator segments are magnetically decoupled from each other. This article introduces different designs of the announced bearingless segment motor featuring different rotor and stator compositions. Especially the differences in the generation of bearing forces are outlined. The special features of the various considered drives are examined and their advantages and drawbacks are discussed. Finally these motors are compared qualitatively by different criteria (like the demands on power electronics, passive stiffnesses or bearing force and motor torque capacity).