gebhart/patrepeval huggingface dataset:
Molecular Targeting of Gene Therapy and Radiotherapy (2001)

The full promise of gene therapy has been limited by the lack of specificity of vectors for tumor tissue as well as the lack of antitumor efficacy of transgenes encoded by gene delivery systems. In this paper we review our studies investigating two modifications of gene therapy combined with radiotherapy. The first investigations described include studies of radiation inducible gene therapy. In this paradigm, radio-inducible DNA sequences from the CarG elements of the Egr-1 promoter are cloned upstream of a cDNA encoding TNF f . The therapeutic gene (TNF f ) is induced by radiation within the tumor microenvironment. In the second paradigm, genetically engineered herpes simplex virus (HSV-1) is induced by ionizing radiation to proliferate within the tumor volume. These modifications of radiotherapy and gene therapy may enhance the efficacy of both treatments.
Effect of Crystallization Temperature of Palm Oil on Its Crystallization. IV. The Influence of Tripalmitoylglycerol (PPP) on the Crystallization of 1,3-dipalmitoyl-2-oleoyl-glycerol (POP) and 1,2-dioleoyl-3-palmitoyl-glycerol (POO) (2007)

Triacylglycerin in Palm Oil contains POP (1,3-dipalmitoyl-2-oleoyl-glycerol) at 30%, POO (1,2-dioleoyl-3-palmitoyl-glycerol) at 20% and PPP (tripalmitoylglycerol) at 5%. The crystallization temperature of PPP is high and the rates of crystal nuclear formation and growth are fast. It is thus considered that PPP may have some effect on the manner or mode of Palm Oil. Examination was thus made to clarify how PPP may affect the crystallization of POP and POO by differential scanning calorimetry (DSC) and X ray diffractometry (XRD) conducted on PPP/POP and PPP/POO mixtures. High and low temperature peaks were noted to appear on the DSC crystallization curve for either of these mixtures. The high temperature peak was considered possibly due to PPP, and the low temperature peak, to POP or POO. DSC isothermal analysis indicated the rate of crystal growth of either mixture to exceed that of pure of POP or POO. Crystal mixture structure was also seen to be complicated than either compound in pure form. The present findings thus clearly indicate that clarification should be made of the effects of high melting point triacylglycerin, such as PPP, on the crystallization of Palm Oil.
Data Curation APIs (2016)

Understanding and analyzing big data is firmly recognized as a powerful and strategic priority. For deeper interpretation of and better intelligence with big data, it is important to transform raw data (unstructured, semi-structured and structured data sources, e.g., text, video, image data sets) into curated data: contextualized data and knowledge that is maintained and made available for use by end-users and applications. In particular, data curation acts as the glue between raw data and analytics, providing an abstraction layer that relieves users from time consuming, tedious and error prone curation tasks. In this context, the data curation process becomes a vital analytics asset for increasing added value and insights. 
In this paper, we identify and implement a set of curation APIs and make them available (on GitHub) to researchers and developers to assist them transforming their raw data into curated data. The curation APIs enable developers to easily add features - such as extracting keyword, part of speech, and named entities such as Persons, Locations, Organizations, Companies, Products, Diseases, Drugs, etc.; providing synonyms and stems for extracted information items leveraging lexical knowledge bases for the English language such as WordNet; linking extracted entities to external knowledge bases such as Google Knowledge Graph and Wikidata; discovering similarity among the extracted information items, such as calculating similarity between string, number, date and time data; classifying, sorting and categorizing data into various types, forms or any other distinct class; and indexing structured and unstructured data - into their applications.
La mesura d'audiències a Catalunya : (2007)

En aquest capitol, l'autor justifica la creacio del Barometre de la Comunicacio i la Cultura,una eina que mesura les audiencies i els usos dels mitjans, i la necessitat de facilitar a les empreses, l'administracio i el pais en general un instrument que reculli la informacio sobre l'especificitat de l'espai comunicatiu catala. En aquest capitol es recullen els arguments que van portar els seus promotors a impulsar la creacio del Barometre i les caracteristiques tecniques del metode de treball que se segueix.
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection (2021)

Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung γδ T cells to produce interleukin 17 A (IL-17A) for early protection against H1N1 influenza infection. During infection, the lung γδ T cell pool is constantly supplemented by thymic output, with recent emigrants infiltrating into the lung parenchyma and airway to acquire tissue-resident feature. Single-cell studies identify IL-17A-producing γδ T (Tγδ17) cells with a phenotype of TCRγδ<sup>hi</sup>CD3<sup>hi</sup>AQP3<sup>hi</sup>CXCR6<sup>hi</sup> in both infected mice and patients with pneumonia. Mechanistically, host cell-released lipids during viral infection are presented by lung infiltrating CD1d<sup>+</sup> B-1a cells to activate IL-17A production in γδ T cells via γδTCR-mediated IRF4-dependent transcription. Reduced IL-17A production in γδ T cells is detected in mice either lacking B-1a cells or with ablated CD1d in B cells. Our findings identify a local host-immune crosstalk and define important cellular and molecular mediators for early innate defense against lung viral infection.
Characterization, purification, and affinity labeling of the brain [3H]glibenclamide-binding protein, a putative neuronal ATP-regulated K+ channel. (1988)

Sulfonylurea and particularly glibenclamide are potent blockers of ATP-regulated K+ channels in insulin-secreting cells. A very good correlation exists between binding of sulfonylurea to brain and insulinoma cell membranes. The [3H]glibenclamide-binding component from pig brain microsomes was solubilized with digitonin with a complete retention of its properties of interaction with glibenclamide and other sulfonylureas. A four-step purification was achieved that used (i) hydroxylapatite chromatography, (ii and iii) affinity chromatographies on ADP-agarose and wheat germ agglutinin-agarose columns, and (iv) a final chromatographic step on a mixture of AMP-agarose/GMP-agarose/hydroxylapatite. This procedure led to a 2500-fold purification. NaDodSO4/polyacrylamide gel electrophoresis of the purified material in reducing and nonreducing conditions showed that the sulfonylurea-binding component is made of a single major polypeptide chain of Mr 150,000 +/- 10,000. Direct photoaffinity labeling of the receptor with [3H]glibenclamide at different steps of the purification also showed that radioactivity was specifically incorporated into a polypeptide of Mr 150,000 +/- 5000, thus confirming the subunit structure indicated by the purification.
Origin of Stick-Slip Motion in Boundary Lubrication (1990)

Molecular dynamics simulations of atomically thin, fluid films confined between two solid plates are described. For a broad range of parameters, a generic stick-slip motion is observed, consistent with the results of recent boundary lubrication experiments. Static plates induce crystalline order in the film. Stick-slip motion involves periodic shear-melting transitions and recrystllization of the film. Uniform motion occurs at high velocities where the film no longer has time to order. These results indicate that the origin of stick-slip motion is thermodynamic instability of the sliding state, rather than a dynamic instability as usually assumed.
An Expressive Hidden Access Policy CP-ABE (2017)

Ciphertext Policy - Attribute Based Encryption (CPABE) has emerged as a feasible solution to address challenges of access control to a diverse set of users. In CP-ABE, owner encrypts its data under a policy of attributes, while any data consumer satisfying it can decrypt the data. Problem of existing CP-ABE schemes is that the access matrix is sent in plaintext along with the ciphertext. Hence, to provide legitimate consumers with capability to figure out their exact attributes satisfying policy; we trade-off the privacy of policy. Existing work focuses on hiding the attribute values, and most of them are based on less expressive And-based access structures. A policy can be considered as hidden, when both attribute's names and their corresponding combination cannot be revealed. To do so, we propose a novel idea of not sending the access matrix along with ciphertext. Moreover, to aid consumer in finding out the subset of his attributes satisfying policy, we exploit Hidden Vector Encryption (HVE) for subset condition checks. We give performance analysis of our scheme in Charm Simulator, and prove it to be selectively secure under DBDH and DLIN assumptions.
OntHoS — an Ontology for Hospital Scenarios (2003)

The goal of this paper is to present an ontology for hospital scenarios (called OntHoS). It was developed by a couple of research projects dealing with the application of agent systems in hospital scenarios. The aim of OntHoS is to establish a basis for a description of these scenarios and to facilitate their inter-operability. Therefore, we classify types of ontologies and approaches to ontology design, we focus on constructing a domain ontology and discuss the proceeding as well as the encountered problems. Finally, an overview about the future work is given, focussing especially on opening the scope to task ontologies for special project-specific purposes
Tunneling characteristics of Pb-CdS-Pb light-sensitive Josephson junctions (1983)

Experimental results concerning Pb-CdS-Pb light-sensitive Josephson junctions are reported. Current-voltage and conductance-voltage characteristics are analyzed in terms of an equivalent rectangular average barrier model. The tunneling barrier characteristic parameters are calculated both in the junction high and low resistance state (before and after illumination).
Human T and B Lymphocytes Express a Structurally Conserved Focal Adhesion Kinase, pp125 <sup>FAK</sup> (1993)

Clustering of beta 1-integrins on adherent cells with antibodies or ligands results in increased tyrosine phosphorylation and activation of a novel focal adhesion tyrosine kinase, pp125FAK. The genes encoding pp125FAK have been cloned previously from both chicken and mouse cDNA libraries, and the deduced amino acid sequences are nearly identical (94%). Two synthetic peptides derived from sequences at the carboxyl terminus of chicken pp125FAK were conjugated to ovalbumin to generate rabbit heteroantisera. Human pp125FAK was immunodetected in both T and B lymphocytes with these antisera. A basal state of pp125FAK tyrosine phosphorylation was observed in T and B lymphocytes, and its expression level was in general augmented among human T- and B-cell leukemia/lymphoma lines. Additionally, the full-length sequence of human T-cell pp125FAK (huT-FAK) was derived from a Jurkat T-cell cDNA library. huT-FAK is structurally identical with both mouse and chicken FAK, and shares 95% amino acid identity with chicken pp125FAK and has 97% homology with the mouse sequence. This high degree of evolutionary conservation between species suggests that pp125FAK is likely to have a crucial function in the cell. Expression of the full-length huT-FAK gene in COS cells showed an immunologically indistinct human pp125FAK protein compared with the endogenous primate pp125FAK. Taken together, the data indicate that this structurally conserved human T-cell pp125FAK likely functions in T- and B-cell lineages, and its altered expression in human lymphocyte tumor cell lines may contribute to their transformed phenotype.
Histamine and Histamine Receptor Antagonists in Cancer Biology (2010)

Histamine has been demonstrated to be involved in cell proliferation, embryonic development, and tumour growth. These various biological effects are mediated through the activation of specific histamine receptors (H1, H2, H3, and H4) that differ in their tissue expression patterns and functions. Although many in vitro and in vivo studies of the modulatory roles of histamine in tumour development and metastasis have been reported, the effect of histamine in the progression of some types of tumours remains controversial; however, recent findings on the role of histamine in the immune system have shed new light on this question. This review focuses on the recent advances in understanding the roles of histamine and its receptors in tumour biology. We report our recent observations of the anti-tumoural effect of H1 histamine antagonists on experimental and human melanomas. We have found that in spite of exogenous histamine stimulated human melanoma cell proliferation, clonogenic ability and migration activity in a dose-dependent manner, the melanoma tumour growth was not modulated by in vivo histamine treatment. On the contrary, terfenadine-treatment in vitro induced melanoma cell death by apoptosis and in vivo terfenadine treatment significantly inhibited tumour growth in murine models. These observations increase our understanding of cancer biology and may inspire novel anticancer therapeutic strategies.
Inductively-Coupled Miniaturized-Element Frequency Selective Surfaces With Narrowband, High-Order Bandpass Responses (2015)

We introduce a new technique for designing miniaturized-element frequency selective surfaces (MEFSSs) with narrowband, bandpass responses of order N ≥ 2. The proposed structure is composed of two-dimensional periodic arrays of subwavelength inductive wire grids separated by dielectric substrates. A simple equivalent circuit model, composed of transmission line resonators coupled together with shunt inductors, is presented for this structure. Using this equivalent circuit model, an analytical synthesis procedure is developed that can be used to synthesize the MEFSS from its desired system-level performance indicators such as the center frequency of operation and bandwidth. Using this synthesis procedure, a prototype of the proposed MEFSS with a second-order bandpass response, center frequency of 21 GHz, and fractional bandwidth of 5% is designed, fabricated, and experimentally characterized. The measurement results confirm the theoretical predictions and the design procedure of the structure and demonstrate that the proposed MEFSS has a stable frequency response with respect to the angle of incidence of the EM wave in the ±40° range for both TE and TM polarizations of incidence.
Clinical and immunologic responses of pigs to African swine fever virus isolated from the Western Hemisphere (1984)

Pigs in the United States were exposed to African swine fever (ASF) virus isolated from pigs in Brazil and the Dominican Republic. The former were examined for clinical response, lesions, viremia, and antibody response. Sequential blood samples were tested for the presence of ASF virus by the hemadsorption test (in swine buffy coat cell culture) and for antibody to ASF virus by the enzyme-linked immunosorbent assay. The incubation period was 3 to 5 days; inoculated pigs had fever for 8 to 16 days (mean 12.5 days) and viremia at 3 to 35 days after inoculation and few died. Inoculated pigs developed antibodies at 7 days after inoculation which were detectable until the termination of the experiment (10th month). Reinoculation of some of the surviving pigs with the homologous isolate at approximately 6 months after exposure did not induce clinical response, viremia, nor anamnestic antibody response. In contrast, challenge exposures of convalescent pigs with the Lisbon-60 viral strain approximately 5 weeks after exposure to the Brazilian strain produced death, in spite of an anamnestic antibody response.
Simple Preparation of New Functionalized Furan Derivatives via Sequential C-C and C-O Bond Formation Mediated by Palladium-Phosphine Catalyst (2006)

Some new substituted mono-, di-, and tricyclic furans were prepared catalytically from commercial and readily available starting materials via palladium-mediated sequential C-C and C-O bond formation in a single operation.
Phosphonylmethoxyalkyl derivatives of purine as inhibitors of human hepatitis B virus DNA synthesis. (1990)

A selected number of antiviral compounds which have been previously shown to inhibit the replication of DNA viruses or retroviruses were examined for their inhibitory effects on human hepatitis B virus (HBV) DNA synthesis. The assay system was based on the use of a human hepatoblastoma cell line (HB611) that continuously synthesizes HBV DNA. The following phosphonylmethoxyalkyl-purine derivatives were found to inhibit HBV DNA synthesis: 9-(2-phosphonyl-methoxyethyl)-2',6'-diaminopurine (PMEDAP), (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA). PMEDAP, HPMPA and PMEA not only inhibit HBV DNA synthesis in HB611 cells but also duck hepatitis B virus (DHBV) DNA and core antigen synthesis in primary duck hepatocytes.
The AIP2 E3 ligase acts as a novel negative regulator of ABA signaling by promoting ABI3 degradation (2005)

The phytohormone abscisic acid (ABA) mediates many complex aspects of plant development including seed maturation, dormancy, and germination as well as root growth. The B3-domain transcription factor abscisic acid-insensitive 3 (ABI3) is a central regulator in ABA signaling, but little is known of how this factor is regulated. Here, we show that ABI3 is an unstable protein and that an ABI3-interacting protein (AIP2), which contains a RING motif, can polyubiquitinate ABI3 in vitro. The AIP2 E3 ligase activity is abolished by mutations (C230S; C231S) in the RING motif and the AIP2 (C/S) mutant functions in a dominant-negative manner. AIP2 has a stronger binding affinity for the B2 + B3 domain of ABI3 than the A1 + B1 domain, but only ubiquitinates the latter. In double-transgenic plants, induced AIP2 expression leads to a decrease in ABI3 protein levels. In contrast, ABI3 levels are elevated upon induced expression of the AIP2 RING mutant, which interferes with the endogenous AIP2 E3 activity. An aip2-1-null mutant shows higher ABI3 protein levels compared with wild type after seed stratification, and is hypersensitive to ABA, mimicking the ABI3-overexpression phenotype, whereas AIP2-overexpression plants contain lower levels of ABI3 protein than wild type and are more resistant to ABA, phenocopying abi3. Our results indicate that AIP2 negatively regulates ABA signaling by targeting ABI3 for post-translational destruction.
High-resolution transmission electron microscopy of mixed-layer clays dispersed in PVP-10: a new technique to distinguish detrital and authigenic illitic material (2000)

Abstract The results of a new technique for the measurement of the thickness distribution of fundamental particles are reported. The technique is based on high-resolution transmission electron microscopy (HRTEM) of Na-saturated mixed-layer illite-smectite dispersed in polyvinylpyrrolidone (PVP-10). Intercalation of PVP-10 increases the spacing of expandable interlayers and changes the arrangement of particles so that the number of layers per fundamental particle can be counted easily on HRTEM images. The data obtained by HRTEM on PVP-10-intercalated illite-smectite of hydrothermal origin are compared with data from the Pt-shadowing technique. A good agreement between the two methods for the measured thickness distributions, mean thickness and expandability confirms the reliability of the new technique. The same technique is applied to a set of four sedimentary samples with different expandabilities (83-18%). The thickness of illite particles from shales and claystones has a lognormal distribution. Detrital anddiscrete illite particles can be distinguished from the thickness distribution of authigenic illite.
Kansas City Cardiomyopathy Questionnaire Utility in Prediction of 30-Day Readmission Rate in Patients with Chronic Heart Failure (2016)

<i>Background</i>. Heart failure (HF) is one of the most common diagnoses associated with hospital readmission. We designed this prospective study to evaluate whether Kansas City Cardiomyopathy Questionnaire (KCCQ) score is associated with 30-day readmission in patients hospitalized with decompensated HF. <i>Methods and Results</i>. We enrolled 240 patients who met the study criteria. Forty-eight (20%) patients were readmitted for decompensated HF within thirty days of hospital discharge, and 192 (80%) patients were not readmitted. Compared to readmitted patients, nonreadmitted patients had a higher average KCCQ score (40.8 versus 32.6, <i>P</i> = 0.019) before discharge. Multivariate analyses showed that a high KCCQ score was associated with low HF readmission rate (adjusted OR = 0.566, <i>P</i> = 0.022). The <i>c</i>-statistic for the base model (age + gender) was 0.617. The combination of home medication and lab tests on the base model resulted in an integrated discrimination improvement (IDI) increase of 3.9%. On that basis, the KCQQ further increased IDI of 2.7%. <i>Conclusions</i>. The KCCQ score determined before hospital discharge was significantly associated with 30-day readmission rate in patients with HF, which may provide a clinically useful measure and could significantly improve readmission prediction reliability when combined with other clinical components.
Effects of the calciotrophic peptides calcitonin and parathyroid hormone on prostate cancer growth and chemotaxis (1997)

The combined proliferation and chemotaxis data suggest that PTH has a dual role in prostate carcinoma resulting in an increase in the number and migration of selected prostate cancer cells. With CT, chemotaxis was unchanged in the DU-145 and PC-3 cells and significantly elevated in the LNCaP cell line. The calciotrophic hormones, PTH and CT, may play an integral role in the regulation of prostate cell growth and metastases.
Media Violence Effects: Confirmed Truth or Just Another X-File? (2009)

This article presents a critical review of the extant literature on media violence effects on violent criminal behavior. Problems within the media violence literature that limit the causal conclusion appropriate to this body of literature are discussed. It is argued that, contrary to common belief, the current literature does not provide ample support for the conclusion that media violence causes aggressive or violent behavior. This article offers positive suggestions for the future of media violence studies. Suggestions for the role of forensic psychologists in communicating media violence research information to courts and the public are also provided.