gebhart/patrepeval huggingface dataset:
Synthesis and Characterization of Poly(ethylene glycol) Methacrylate Based Hydrogel Networks for Anti‐Biofouling Applications (2012)

Abstract A series of hydrogels based on poly(ethylenglycol) methyl ether methacrylate (PEGMEMA) is synthesized using macromonomers of three different molecular weights, in combination with varied degrees of chemical crosslinking. The effects of PEGMEMA, initiator, and crosslinker concentrations on gel yield and swelling properties are studied. In addition, the chemical structure of the gels is characterized by FTIR and solid‐state NMR spectra. The swelling and rheological behaviors of hydrogels as well as protein partitioning into the gels are discussed in terms of the network mesh size. Low protein sorption and bacteria deposition tendencies indicate that PEGMEMA‐based hydrogels could be highly beneficial for uses as fouling‐resistant materials, for instance, as protective coatings for desalination membranes. magnified image
Chiral C1-Symmetric Group 4 Metallocenes as Catalysts for Stereoregular .alpha.-Olefin Polymerization. Metal, Ancillary Ligand, and Counteranion Effects (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral C1-Symmetric Group 4 Metallocenes as Catalysts for Stereoregular .alpha.-Olefin Polymerization. Metal, Ancillary Ligand, and Counteranion EffectsMichael A. Giardello, Moris S. Eisen, Charlotte L. Stern, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1995, 117, 49, 12114–12129Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ja00154a012https://doi.org/10.1021/ja00154a012research-articleACS PublicationsRequest reuse permissionsArticle Views609Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Lung Cancer Mortality in the Mayo Lung Project: Impact of Extended Follow-up (2000)

Extended follow-up of MLP participants did not reveal a lung cancer mortality reduction for the intervention arm. Similar mortality but better survival for individuals in the intervention arm indicates that some lesions with limited clinical relevance may have been identified in the intervention arm.
The Pig as an Experimental Animal Model of Percutaneous Permeation in Man: Qualitative and Quantitative Observations – An Overview (2000)

The pig has been a well-recognized experimental animal in biomedical research for many centuries. Physiological and anatomical similarities between man and pig made this animal a good model for man in many research areas. Pharmacological and toxicological research on the skin is often based on knowledge of skin absorption and percutaneous permeation. Anatomical, physiological and biochemical similarities are cited and various uses of the pig as a model for man in the investigation of skin permeation are reviewed. Further, several isolated organ models are reviewed. The importance of full details of the experimental animal, namely its age, sex, breed, size (weight) and body region, is emphasized.
Configuring a Context-Aware Middleware for Wireless Sensor Networks (2012)

In the Future Internet, applications based on Wireless Sensor Networks will have to support reconfiguration with minimum human intervention, depending on dynamic context changes in their environment. These situations create a need for building these applications as adaptive software and including techniques that allow the context acquisition and decisions about adaptation. However, contexts use to be made up of complex information acquired from heterogeneous devices and user characteristics, making them difficult to manage. So, instead of building context-aware applications from scratch, we propose to use FamiWare, a family of middleware for Ambient Intelligence specifically designed to be aware of contexts in sensor and smartphone devices. It provides both, several monitoring services to acquire contexts from devices and users, and a context-awareness service to analyze and detect context changes. However, the current version of FamiWare does not allow the automatic incorporation related to the management of new contexts into the FamiWare family. To overcome this shortcoming, in this work, we first present how to model the context using a metamodel to define the contexts that must to be taken into account in an instantiation of FamiWare for a certain Ambient Intelligence system. Then, to configure a new context-aware version of FamiWare and to generate code ready-to-install within heterogeneous devices, we define a mapping that automatically transforms metamodel elements defining contexts into elements of the FamiWare family, and we also use the FamiWare configuration process to customize the new context-aware variant. Finally, we evaluate the benefits of our process, and we analyze both that the new version of the middleware works as expected and that it manages the contexts in an efficient way.
Assessment of the clinical usefulness of nebulised ipratropium bromide in patients with chronic airflow limitation. (1984)

The effect of adding nebulised ipratropium bromide to bronchodilator treatment was studied in 20 patients with severe chronic airflow limitation. Maintenance theophylline with or without a steroid preparation was continued and comparison made between placebo, nebulised salbutamol, and a combination of nebulised salbutamol and ipratropium. Although the mean FEV1 values showed the combination to produce a small but significant increase in peak bronchodilatation over the effect of salbutamol alone, there were eight patients in whom no clinically useful improvement occurred. The remaining 12 patients did obtain clinically useful improvement in the magnitude or the duration of bronchodilatation (or both) as a result of the added ipratropium. The conclusion is that individual patients with chronic airflow limitation responded to the addition of nebulised ipratropium bromide in a variable way. Patients who could obtain additional benefit from ipratropium need to be identified by an appropriate reversibility study before its inclusion in their bronchodilator treatment.
Betanodavirus B2 protein triggers apoptosis and necroptosis in lung cancer cells that suppresses autophagy (2017)

The betanodavirus B2 protein targets the mitochondria and acts as a "death factor", but its effect on lung cancer cells is unknown. We examined the effect of the B2 protein on triggering apoptosis or necroptosis <i>via</i> P53-dependent and P53-independent pathways and increased in suppression of autophagy. The B2 protein targets the mitochondria of A549 (P53<sup>+/+</sup>) and H1299 (P53<sup>-/-</sup>) lung cancer cells due to a specific signal sequence (<sup>41</sup>RTFVISAHAA<sup>50</sup>). This triggers generation of reactive oxygen species within the mitochondria, and a minor stress response in A549 cells, but a strong stress response in H1299 cells. We examined the molecular mechanism of this cell death pathway, and found that B2 protein induces the P53/Bax-mediated apoptotic pathway in A549 cells, and that a P53 specific inhibitor (pifithrin-α) switches this response to RIP3-mediated necroptosis. On the other hand, B2 induces RIP3-mediated necroptosis pathway in H1299 cells, and a necroptosis inhibitor (necrostatin-1) switches this response to the apoptotic pathway. Both types of cell death signals inhibited autophagy <i>via</i> a tightly increased balance of beclin-1 and Bcl-2. Thus, B2 protein triggers P53-dependent apoptosis in A549 cells and ROS/RIP3-mediated necroptosis in H1299 cells, and crosstalk of these pathways limits initiation of autophagy. These findings provide new insights into the possible control and treatment of lung cancer.
Dual-Function Gate Driver for a Power Module With SiC Junction Field-Effect Transistors (2013)

Silicon Carbide high-power modules populated with several parallel-connected junction field-effect transistors must be driven properly. Parasitic elements could act as drawbacks in order to achieve fast and oscillation-free switching performance, which are the main goals. These two requirements are related closely to the design of the gate-drive unit, and they must be kept under certain limits when high efficiencies are targeted. This paper deeply investigates several versions of gate-drive units and proposes a dual-function gate-drive unit which is able to switch the module with an acceptable speed without letting the current suffer from significant oscillations. It is experimentally shown that turn-on and turn-off switching times of approximately 130 and 185 ns respectively can be reached, while the magnitude of the current oscillations is kept at an adequate level. Moreover, using the proposed gate driver an efficiency of approximately 99.7% is expected for a three-phase converter rated at 125 kVA and having a switching frequency of 2 kHz.
Endothelial Senescence Contributes to Heart Failure With Preserved Ejection Fraction in an Aging Mouse Model (2017)

SAM develop endothelial dysfunction. Adding a high-salt, high-fat diet accelerates endothelial senescence and instigates endothelial inflammation. This coincides with hemodynamic and structural changes typical of HFpEF. Targeting endothelial senescence could be a new therapeutic avenue in HFpEF.
PSYCHOMETRIC PROPERTIES OF THE OXFORD HAPPINESS QUESTIONNAIRE SHORT FORM IN UNIVERSITY STUDENTS (2016)

This study aimed at exploring psychometric properties of the Oxford Happiness Questionnaire short form. To this end, 494 university students were randomly selected from different universities located in Tehran city. The research instruments were the Oxford Happiness Questionnaire, the Satisfaction with Life Scale, and Rosenberg’s Self-Esteem Scale. Results of a Confirmatory Factor Analysis indicated that the Oxford Happiness Questionnaire measures happiness as a unidimensional construct. The Cronbach’s alpha coefficient of the questionnaire was found to be 0.71 for whole population, 0.71 for female and 0.70 for male samples which is satisfactory. Results of a Pearson correlation revealed that there was a positive and significant relationship between the short and long form happiness questionnaire’s scores, satisfaction with life, and self-esteem. Also, the female university students’ mean score was higher than their male counterparts. The results of the research indicated that the Oxford Happiness Questionnaire Short Form has acceptable psychometric characteristics among university students and it can be used as a valid instrument in psychological research.
Selective Laser Melting of Titanium Alloys and Titanium Matrix Composites for Biomedical Applications: A Review (2015)

Titanium materials are ideal targets for selective laser melting (SLM), because they are expensive and difficult to machinery using traditional technologies. After briefly introducing the SLM process and processing factors involved, this paper reviews the recent progresses in SLM of titanium alloys and their composites for biomedical applications, especially developing new titanium powder for SLM. Although the current feedstock titanium powder for SLM is limited to CP‐Ti, Ti–6Al–4V, and Ti–6Al–7Nb, this review extends attractive progresses in the SLM of all types of titanium, composites, and porous structures including Ti–24Nb–4Zr–8Sn and Ti–TiB/TiC composites with focus on the manufacture by SLM and resulting unique microstructure and properties (mechanical, wear/corrosion resistance properties).
Chaotic detection of small target in sea clutter (1993)

A new method based on chaos and neural network theory for small target detection in sea clutter is presented. The authors present the signal model. They then describe a neural network trained with the least-mean-square (LMS) algorithm for the dynamic reconstruction of sea clutter. A chaotic detection algorithm based on the neural network model is described. Some experimental results show that the new detection method operating with noncoherent radar data has a performance comparable with that of a standard Doppler CFAR processor.< <ETX>></ETX>
Blue light treatment of<i>Pseudomonas aeruginosa</i>: Strong bactericidal activity, synergism with antibiotics and inactivation of virulence factors (2016)

Pseudomonas aeruginosa is among the most common pathogens responsible for both acute and chronic infections of high incidence and severity. Additionally, P. aeruginosa resistance to conventional antimicrobials has increased rapidly over the past decade. Therefore, it is crucial to explore new therapeutic options, particularly options that specifically target the pathogenic mechanisms of this microbe. The ability of a pathogenic bacterium to cause disease is dependent upon the production of agents termed 'virulence factors', and approaches to mitigate these agents have gained increasing attention as new antibacterial strategies. Although blue light irradiation is a promising alternative approach, only limited and preliminary studies have described its effect on virulence factors. The current study aimed to investigate the effects of lethal and sub-lethal doses of blue light treatment (BLT) on P. aeruginosa virulence factors. We analyzed the inhibitory effects of blue light irradiation on the production/activity of several virulence factors. Lethal BLT inhibited the activity of pyocyanin, staphylolysin, pseudolysin and other proteases, but sub-lethal BLT did not affect the production/expression of proteases, phospholipases, and flagella- or type IV pili-associated motility. Moreover, a eukaryotic cytotoxicity test confirmed the decreased toxicity of blue light-treated extracellular P. aeruginosa fractions. Finally, the increased antimicrobial susceptibility of P. aeruginosa treated with sequential doses of sub-lethal BLT was demonstrated with a checkerboard test. Thus, this work provides evidence-based proof of the susceptibility of drug-resistant P. aeruginosa to BLT-mediated killing, accompanied by virulence factor reduction, and describes the synergy between antibiotics and sub-lethal BLT.
Modular simulation of a hybrid power system with diesel, photovoltaic inverter and wind turbine generation (2008)

The dynamic behavior and stability of an isolated electric power system, fed by a conventional energy plant and a renewable energy system, is presented in this paper. Matlab/Simulink is the used software for simulating the whole system.
Improving gene therapy (2009)

Retroviral mediated gene therapy has progressed along with advances in biological science. Existing PT67 and Amphotropic-Phoenix retroviral packaging cell lines can be made more efficient to produce higher retroviral titers, giving rise to more efficient gene transfer. Here, an IRES-mcherry gene was cloned into two env-expressing plasmid vectors - pAmpho and p10A1. Under the control of the cytomegalovirus (CMV) promoter and the internal ribosomal entry site (IRES), the expression of the envelope protein encoded by the env-expressing vectors would be indicated by the presence of red fluorescence from mcherry. Packaging cells expressing high levels of mcherry could then be selected to generate efficient packaging cell lines. However, transfection of the packaging cell lines with the recombinant envelope plasmids showed that the transfected cells either did not express mcherry, or, if they did, mcherry was expressed at a very low level. Retroviruses produced from these packaging lines transfected with the recombinant envelope plasmids were used to infect wild-type Jurkat T-cells. FACS analysis of these Jurkat T-cells indicated that the packaging lines did produce retroviral particles expressing the env protein. Although the yield of these retroviral particles did not increase with co-transfection of these packaging lines with the constructed envelope plasmids, the expressed env protein enhanced the efficiency of infection.
A proof-of-concept fluorescence lifetime camera based on a novel gated image sensor for fluorescence-guided surgery (2019)

Fluorescence imaging using near-infrared (NIR) fluorescent contrast agents is increasingly being investigated as intraoperative tool to visualize, in real-time, tissues of interest such as tumors, lymph nodes or nerve bundles. Generally, spectral imaging systems are used that measure the intensity of fluorescent signals. However, to aid in a more specific detection of these fluorescent signals, fluorescence lifetime can be added to the image. The lifetime is independent of the intensity and in addition, multiple tracers emitting around the same wavelengths can still be distinguished based on their difference in lifetime. Imaging lifetimes, however, requires a much more advanced imaging system. None of the currently approved fluorescence guidance systems support fluorescence lifetime and today’s available lifetime imaging technology (TCSPC, ICCD) does not allow imaging the sub-nanosecond lifetimes of NIR dyes with the efficiency needed to reach video frame rates. In this paper, we present a 32×32-pixel proof-of-concept camera based on our novel CAPS-pixel based gated image sensor. This camera is specifically targeted at imaging fluorescence lifetimes at NIR wavelengths with high efficiency for the use in fluorescence-guided surgery and is a first step towards a full camera with video resolution at video frame rates. We describe the camera system and how it is used to image fluorescence lifetimes. Next, we show the lifetime imaging capability by imaging the lifetimes of two different nanosecond visible dyes (fluorescein and acridine orange) in cuvette and two more challenging (sub-)nanosecond NIR dyes (ICG and IRDye800CW). Lastly, we validate the camera by imaging NIR fluorescence phantoms in a mouse.
Optimizing a mine haul truck wheel motors’ condition monitoring program Use of proportional hazards modeling (2001)

Discusses work completed at Cardinal River Coals in Canada to improve the existing oil analysis condition monitoring program being undertaken for wheel motors. Oil analysis results from a fleet of 55 haul truck wheel motors were analyzed along with their respective failures and repairs over a nine‐year period. Detailed data cleaning procedures were applied to prepare data for modeling. In addition, definitions of failure and suspension were clarified depending on equipment condition at replacement. Using the proportional hazards model approach, the key condition variables relating to failures were found from among the 19 elements monitored, plus sediment and viscosity. Those key variables were then incorporated into a decision model that provided an unambiguous and optimal recommendation on whether to continue operating a wheel motor or to remove it for overhaul on the basis of data obtained from an oil sample. Wheel motor failure implied extensive planetary gear or sun gear damage necessitating the replacement of one or more major internal components in a general overhaul. The decision model, when triggered by incoming data, provided both a recommendation based on an optimal decision policy as well as an estimate of the unit’s remaining useful life. By optimizing the times of repair as a function both of age and condition data a 20‐30 percent potential savings in overhaul costs over existing practice was identified.
Roles of Cytochrome P450 in Development (2001)

Cytochrome P450 (CYP) forms are ubiquitous in nature, appearing in almost all phyla, with many forms appearing in any organism. About 50 different forms have been identified in man, and some of these are found in the embryo, some showing temporal dependence. Many of the forms of cytochrome P450 present in one species have homologues in other species. For example, CYP1A2 is present in many species, including man, rabbits, rodents, fish and fowl. The amino acid sequence identity of these homologues is often in excess of 70%. CYP26, too, has more than 61% identity in amino acid sequence between fish, fowl and mammals. In view of the high degree of conservation of sequence as well as of enzymatic activities, it is only reasonable to assume that such strong conservation of sequence also reflects a conservation of function. Since the 'xenobiotic metabolizing' enzymes predate the production of the many xenobiotics they are known to metabolize, perhaps it is reasonable to consider endobiotics as natural substrates for their metabolism. Of the identified forms of cytochrome P450 that are present in embryonic tissue, we consider the possibility that they serve the organism in support of morphogenesis of the embryonic tissue. These forms may either function to generate morphogenic molecules or to keep regions free of them, thereby creating temporal and spatial regions of morphogen action and supporting region-specific changes in cells. One known morphogen, retinoic acid, has the enzymes retinal dehydrogenase (RALDH) and CYP26 maintaining its actions, the former responsible for its generation and the latter for its elimination. Another form of cytochrome P450, CYP1B1 appears also to be involved in differentiation of tissue, with its absence resulting in primary congenital glaucoma. However, the nature of the morphogen it may maintain still remains to be elucidated.
[Neoadjuvant chemotherapy of breast cancer]. (2007)

近年来乳腺癌的术前化疗,即新辅助化疗(neoadjuvant chemotherapy,NCT)已成为乳腺癌治疗的热点[1-2 ].20世纪70年代意大利米兰肿瘤研究所首先用于治疗不可手术的局部晚期乳腺癌(locally advanced breast cancer,LABC),获得了比较理想的疗效,一些不可切除的经化疗后变为可切除。
Transmission of embedded VBR multimode encoded speech on UMTS common packet channels (2002)

Being a W-CDMA system, UMTS is intrinsically able to support variable bit-rate dedicated channels. For more bursty traffic sources, UMTS adopts a packet-switched approach, which tailors particularly time-unconstrained data services. This article investigates the performance of UMTS uplink common packet channels (CPCH) when dealing with real-time variable bit-rate traffic. In the presented case study, UMTS shared channels convey the lower priority bit stream produced by a multimode speech encoder in combination with dedicated channels devoted to transport the higher priority core-coding flow. The shared channels are requested on demand following a MAC protocol similar to slotted-Aloha. Simulation results highlight the critical aspects of the original protocol in the unbounded interference rise and in the large access delay. Better performance are obtained when the power control commands exchanged on the dedicated channel are exploited to rule the transmitting power level in the CPCH access procedure.