gebhart/patrepeval huggingface dataset:
Electrochemical Processing, Inorganic (2000)

Abstract Electrochemical processes are used to produce an array of reactive inorganic chemicals and metals. The most reactive materials, strongest oxidants, and strongest reductants are produced electrochemically at anodes and cathodes, respectively. Process technology for the production of each electrochemical is unique. Power supplies and electrolytic cells are the distinguishing features of electrochemical processes. Electrolytic cells use direct current and are designed to be process specific. Every cell consists of an anode, a cathode, and container. Cells may be monopolar or bipolar, with or without separators, and equipped to handle aqueous solutions or fused salt electrolytes. Industrial processes described include electrolysis of chloride solutions and production of manganese dioxide, fluorine, permanganate, and hydrogen peroxide. The electrolysis of water and production of heavy water are also described. Processes for electrowinning of metals from aqueous solutions and from fused salts are discussed as are electrochemical processes for hazardous waste treatment systems.
Intrinsic Regulators of Pancreatic β-Cell Proliferation (2006)

Once thought incapable of significant proliferation, the pancreatic beta-cell has recently been shown to harbor immense powers of self-renewal. Pancreatic beta-cells, the sole source of insulin in vertebrate animals, can grow facultatively to a degree unmatched by other organs in experimental animals. beta-cell growth matches changes in systemic insulin demand, which increase during common physiologic states such as aging, obesity, and pregnancy. Compensatory changes in beta-cell mass are controlled by beta-cell proliferation. Here we review recent advances in our understanding of the intrinsic factors and mechanisms that control beta-cell cycle progression. Dysregulation of beta-cell proliferation is emerging as a fundamental feature in the pathogenesis of human disease states such as cancer and diabetes mellitus. New experimental observations and studies of these diseases suggest that beta-cell fate and expansion are coordinately regulated. We speculate on how these advances may accelerate the discovery of new strategies for the treatment of diseases characterized by a deficiency or excess of beta-cells.
liteFlow: Lightweight and distributed flow monitoring platform for SDN (2015)

Traditional network monitoring involving packet capturing or flow sampling has many challenges such as scalability, accuracy and availability of processing resource when networks become large-scale, high-speed and heterogeneous. SDN is a promising approach to address these challenges, but each SDN switch has it's own capacity limitation, such as it's cache memory called TCAM, and thus it needs coordination of resources with other network nodes to monitor the network in a scalable manner. liteFlow introduces an intelligent framework for authority switch selection, which is in charge of monitoring all flows between an end-hosts pair, while the other path switches simply forward packets without any monitoring process. The proposed system distributes the load of monitoring flows among SDN switches, and makes the scalability and accuracy of network monitoring manageable. This paper also implements a few metrics for flow-based network monitoring as example applications of liteFlow. The proof of concept implementation has been done using SDN testbed partially involving campus network of IIT Hyderabad.
Guanine‐Based Biogenic Photonic‐Crystal Arrays in Fish and Spiders (2009)

Abstract Biological photonic systems composed of anhydrous guanine crystals evolved separately in several taxonomic groups. Here, two such systems found in fish and spiders, both of which make use of anhydrous guanine crystal plates to produce structural colors, are examined. Measurements of the photonic‐crystal structures using cryo‐SEM show that the crystal plates in both fish skin and spider integument are ∼20‐nm thick. The reflective unit in the fish comprises stacks of single plates alternating with ∼230‐nm‐thick cytoplasm layers. In the spiders the plates are formed as doublet crystals, cemented by 30‐nm layers of amorphous guanine, and are stacked with ∼200 nm of cytoplasm between crystal doublets. They achieve light reflective properties through the control of crystal morphology and stack dimensions, reaching similar efficiencies of light reflectivity in both fish skin and spider integument. The structure of guanine plates in spiders are compared with the more common situation in which guanine occurs in the form of relatively unorganized prismatic crystals, yielding a matt white coloration.
Asynchronous rate control for multi-object videos (2005)

Object-based coding can potentially achieve a higher degree of compression and better visual quality. The objects in a scene are not always synchronous, that is, they have different temporal resolutions. In some applications, it is more efficient to transmit asynchronous objects with different temporal rates so as to achieve a better tradeoff between temporal and spatial resolutions. This requires to balance the qualities of individual objects while ensuring an overall visual quality with a given bit rate. This paper proposes a rate control algorithm for multiple video object encoding, which is suitable for both synchronous and asynchronous transmissions. The algorithm aims to maximize scene quality with an accurate bit rate, while efficiently handling buffer fullness. Using an efficient bit allocation strategy, the algorithm achieves accurate target bit rates, provides good coding quality, and decreases buffer overflow/underflow. The proposed algorithm also allows flexible priority adjustment among multiple objects to ensure overall better visual perception. Designed primarily for asynchronous objects, the algorithm treats the synchronous objects as a special case. Experimental results demonstrate that, when giving suitable asynchronous video object planes rates, the proposed algorithm achieves good temporal-spatial tradeoff while yielding accurate rate regulation and effective buffer control.
Human neuroblastoma cells produce the NF‐<i>k</i>B‐like HIV‐1 transcription activator during differentiation (1993)

Human neuroblastoma GOTO and IMR32 cells differentiate into neural cells on treatment with 5-BrdU. Here we report that in association with differentiation induced by 5-BrdU, the transcription of HIV-1 was activated in both neuroblastoma cell lines. An NF-kappa B-like factor was also found to be produced in association with the neural cell differentiation of these cells. These results suggest that, during differentiation of neural cells, an NF-kappa B-like factor was produced, and that when the neural cells are infected with HIV-1 the production of NF-kappa B results in activation of transcription of HIV-1. Thus this NF-kappa B-like factor may be involved in the mechanism causing AIDS dementia.
Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer (2015)

The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment. What maintains heterogeneity remains an open question because competition within a tumor leads to a strong selection for the fittest subclone. Cancer cells also cooperate by sharing molecules with paracrine effects, such as growth factors, and heterogeneity can be maintained if subclones depend on each other for survival. Without strict interdependence between subclones, however, nonproducer cells can free-ride on the growth factors produced by neighboring producer cells, a collective action problem known in game theory as the "tragedy of the commons," which has been observed in microbial cell populations. Here, we report that similar dynamics occur in cancer cell populations. Neuroendocrine pancreatic cancer (insulinoma) cells that do not produce insulin-like growth factor II (IGF-II) grow slowly in pure cultures but have a proliferation advantage in mixed cultures, where they can use the IGF-II provided by producer cells. We show that, as predicted by evolutionary game theory, producer cells do not go extinct because IGF-II acts as a nonlinear public good, creating negative frequency-dependent selection that leads to a stable coexistence of the two cell types. Intratumor cell heterogeneity can therefore be maintained even without strict interdependence between cell subclones. Reducing the amount of growth factors available within a tumor may lead to a reduction in growth followed by a new equilibrium, which may explain relapse in therapies that target growth factors.
Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma (2019)

Denileukin diftitox (DAB-IL-2, Ontak) is a diphtheria-toxin-based fusion protein that depletes CD25-positive cells including regulatory T cells and has been approved for the treatment of persistent or recurrent cutaneous T cell lymphoma. However, the clinical use of denileukin diftitox was limited by vascular leak toxicity and production issues related to drug aggregation and purity. We found that a single amino acid substitution (V6A) in a motif associated with vascular leak induction yields a fully active, second-generation biologic, s-DAB-IL-2(V6A), which elicits 50-fold less human umbilical vein endothelial cell monolayer permeation and is 3.7-fold less lethal to mice by LD<sub>50</sub> analysis than s-DAB-IL-2. Additionally, to overcome aggregation problems, we developed a production method for the fusion toxin using <i>Corynebacterium diphtheriae</i> that secretes fully folded, biologically active, monomeric s-DAB-IL-2 into the culture medium. Using the poorly immunogenic mouse B16F10 melanoma model, we initiated treatment 7 days after tumor challenge and observed that, while both s-DAB-IL-2(V6A) and s-DAB-IL-2 are inhibitors of tumor growth, the capacity to treat with higher doses of s-DAB-IL-2(V6A) could provide a superior activity window. In a sequential dual-therapy study in tumors that have progressed for 10 days, both s-DAB-IL-2(V6A) and s-DAB-IL-2 given before checkpoint inhibition with anti-programmed cell death-1 (anti-PD-1) antibodies inhibited tumor growth, while either drug given as monotherapy had less effect. s-DAB-IL-2(V6A), a fully monomeric protein with reduced vascular leak, is a second-generation diphtheria-toxin-based fusion protein with promise as a cancer immunotherapeutic both alone and in conjunction with PD-1 blockade.
Self-stresses and crack formation by particle swelling in cohesive granular media (2005)

We present a molecular-dynamics study of force patterns, tensile strength, and crack formation in a cohesive granular model where the particles are subjected to swelling or shrinkage gradients. Nonuniform particle size change generates self-equilibrated forces that lead to crack initiation as soon as the strongest tensile contacts begin to fail. We find that the tensile strength is well below the theoretical strength as a result of inhomogeneous force transmission in granular media. The cracks propagate either inward from the edge upon shrinkage or outward from the center upon swelling. We show that the coarse-grained stresses are correctly predicted by an elastic model that incorporates particle size change as metric evolution.
Relationship between erucic acid and myocardial changes in male rats (1976)

Abstract The back and belly fat of pigs fed a diet containing 20% by wt rapeseed oil (22% erucic acid) for 16 weeks was rendered into oil. This rendered pig fat, which contained 5.6% erucic acid, was fed to male rats in three separate experiments at 20% by wt of the diet for 16 weeks. In experiment I rendered pig fat was compared only to Brassica campestris var. Span rapeseed oil containing 4.8% erucic acid. In experiments II and III, rendered pig fat was compared to commerical lard containing 0.2% docosenoic acid, commercial lard to which 5.4% free erucic acid was added, and Span rapessed oil. There was no significant (P<0.01) differences observed in the level of erucic acid in the hearts of rats fed diets of rendered pig fat, Span rapeseed oil, or commercial lard plus erucic acid. However, the incidence (P<0.001) and severity (P<0.01) of cardiac lesions were significantly higher in Span rapeseed oil fed rats compared to rats fed control diets. The number of rats affected or the severity of lesions in the rendered pig fat fed group was not significantly different from controls. The results of this study indicate that the myocardial lesions associated with feeding 20% rapeseed oil diets are not related to the content of erucic acid per se. The possible reasons why rapeseed oil causes cardiac lesions in rats are discussed. It is suggested that a triglyceride imbalance in the oil might play an important role in causing these lesions in rats.
Technology overview: SonoVue (Bracco, Milan). (2004)

Ultrasound contrast agents introduced to sonography the possibility to demonstrate microvascular organization and parenchymal perfusion. In combination with modern contrast-specific imaging modalities, contrast agent signals can be separated from tissue-derived signals, allowing the detection of extremely small quantities of contrast agent. The following article describes the physical principles for the creation of contrast-specific signals, the particular physicochemical characteristics of SonoVue, a second-generation ultrasound contrast agent, and the resulting possibilities for the assessment of physiological functions.
Sleep Disorders in Parkinsonian Macaques: Effects of L-Dopa Treatment and Pedunculopontine Nucleus Lesion (2014)

Patients with Parkinson's disease (PD) display significant sleep disturbances and daytime sleepiness. Dopaminergic treatment dramatically improves PD motor symptoms, but its action on sleep remains controversial, suggesting a causal role of nondopaminergic lesions in these symptoms. Because the pedunculopontine nucleus (PPN) regulates sleep and arousal, and in view of the loss of its cholinergic neurons in PD, the PPN could be involved in these sleep disorders. The aims of this study were as follows: (1) to characterize sleep disorders in a monkey model of PD; (2) to investigate whether l-dopa treatment alleviates sleep disorders; and (3) to determine whether a cholinergic PPN lesion would add specific sleep alterations. To this end, long-term continuous electroencephalographic monitoring of vigilance states was performed in macaques, using an implanted miniaturized telemetry device. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment induced sleep disorders that comprised sleep episodes during daytime and sleep fragmentation and a reduction of sleep efficiency at nighttime. It also induced a reduction in time spent in rapid eye movement (REM) sleep and slow-wave sleep and an increase in muscle tone during REM and non-REM sleep episodes and in the number of awakenings and movements. l-Dopa treatment resulted in a partial but significant improvement of almost all sleep parameters. PPN lesion induced a transient decrease in REM sleep and in slow-wave sleep followed by a slight improvement of sleep quality. Our data demonstrate the efficacy of l-dopa treatment in improving sleep disorders in parkinsonian monkeys, and that adding a cholinergic PPN lesion improves sleep quality after transient sleep impairment.
Optical Testing for Passive Optical Networks (2008)

This paper reviews the demand for and the current status of PON optical diagnostics. Special focus is given to methods of optical testing that use capabilities that are incorporated into the transmission equipment itself.
核保障:过去、现在和未来 (1997)

可自由接受的旨在核实遵守国际条约或协定情况的现场检查的概念,是第二次世界大战后的新鲜事。1945年以前,很少有对系统化核查的需求。过去,某条约是否得到遵守很快就会弄明白——例如,如果它要求转让领土或者奴隶贸易垄断之类的商业特许或惩罚性赔偿或公主婚事的允诺,若另一
Preparation and characterization of ceria under an oxidizing atmosphere. Thermal analysis, XPS, and EPR study (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and characterization of ceria under an oxidizing atmosphere. Thermal analysis, XPS, and EPR studyEdmond Abi-aad, Rafeh Bechara, Jean Grimblot, and Antoine AboukaisCite this: Chem. Mater. 1993, 5, 6, 793–797Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/cm00030a013https://doi.org/10.1021/cm00030a013research-articleACS PublicationsRequest reuse permissionsArticle Views2602Altmetric-Citations197LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experimental Investigation of Energy-Efficient Digital Circuits Based on eSFQ Logic (2013)

We present the design and results of experimental verification methods for ultra-low-power digital circuits based on the recently introduced energy-efficient single flux quantum (eSFQ) logic. Similar to another low-power SFQ logic, ERSFQ, eSFQ circuits make use of superconducting dc bias current dividers and thus avoid static power dissipation. As a result, per-gate power dissipation is reduced by two orders of magnitude as compared to conventional rapid single flux quantum and static power dissipation is zero. The eSFQ circuits are fabricated using the HYPRES standard 4.5 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> process. We integrate a low-pass analog-to-digital modulator with our eSFQ deserializer to enable testing at high speed. In this paper, we demonstrate the viability and performance metrics of eSFQ circuits through functional and high-speed tests. Specifically, we confirmed correct operation and present measured parameter margins.
Design and experimental verification of a direct-drive interior PM synchronous machine using a saturable lumped-parameter model (2003)

This paper presents the design and experimental verification of a 6 kW interior permanent magnet (IPM) synchronous machine intended for an automotive direct-drive starter/alternator application. The machine was designed using a saturable lumped-parameter magnetic circuit model in combination with a Monte Carlo optimization process that minimized the machine-plus-converter cost. An experimental IPM machine has been constructed based on the resulting design specifications. Laboratory tests have confirmed the accuracy of the analytical models for predicting the q-axis inductance L/sub q/ (including saturation effects) and the torque production characteristics, but discrepancies between the predicted and measured d-axis inductance L/sub d/ were revealed. The impact of these differences on machine performance is discussed, as well as potential adjustments in the IPM analytical model to improve the performance of future machines.
Can molecular dynamics simulations provide high‐resolution refinement of protein structure? (2007)

Recent advances in efficient and accurate treatment of solvent with the generalized Born approximation (GB) have made it possible to substantially refine the protein structures generated by various prediction tools through detailed molecular dynamics simulations. As demonstrated in a recent CASPR experiment, improvement can be quite reliably achieved when the initial models are sufficiently close to the native basin (e.g., 3-4 A C(alpha) RMSD). A key element to effective refinement is to incorporate reliable structural information into the simulation protocol. Without intimate knowledge of the target and prediction protocol used to generate the initial structural models, it can be assumed that the regular secondary structure elements (helices and strands) and overall fold topology are largely correct to start with, such that the protocol limits itself to the scope of refinement and focuses the sampling in vicinity of the initial structure. The secondary structures can be enforced by dihedral restraints and the topology through structural contacts, implemented as either multiple pair-wise C(alpha) distance restraints or a single sidechain distance matrix restraint. The restraints are weakly imposed with flat-bottom potentials to allow sufficient flexibility for structural rearrangement. Refinement is further facilitated by enhanced sampling of advanced techniques such as the replica exchange method (REX). In general, for single domain proteins of small to medium sizes, 3-5 nanoseconds of REX/GB refinement simulations appear to be sufficient for reasonable convergence. Clustering of the resulting structural ensembles can yield refined models over 1.0 A closer to the native structure in C(alpha) RMSD. Substantial improvement of sidechain contacts and rotamer states can also be achieved in most cases. Additional improvement is possible with longer sampling and knowledge of the robust structural features in the initial models for a given prediction protocol. Nevertheless, limitations still exist in sampling as well as force field accuracy, manifested as difficulty in refinement of long and flexible loops.
Introduction to Polymer Chemistry (2012)

Continuing the tradition of its previous editions, the third edition of Introduction to Polymer Chemistry provides a well-rounded presentation of the principles and applications of natural, synthetic, inorganic, and organic polymers. With an emphasis on the environment and green chemistry and materials, this third edition offers detailed coverage o
Protein Phosphatases: Properties and Role in Cellular Regulation (1983)

Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.