gebhart/patrepeval huggingface dataset:
Effect of Crystallographic Structure of MnO<sub>2</sub> on Its Electrochemical Capacitance Properties (2008)

MnO2 is currently under extensive investigations for its capacitance properties. MnO2 crystallizes into several crystallographic structures, namely, α, β, γ, δ, and λ structures. Because these structures differ in the way MnO6 octahedra are interlinked, they possess tunnels or interlayers with gaps of different magnitudes. Because capacitance properties are due to intercalation/deintercalation of protons or cations in MnO2, only some crystallographic structures, which possess sufficient gaps to accommodate these ions, are expected to be useful for capacitance studies. In order to examine the dependence of capacitance on crystal structure, the present study involves preparation of these various crystal phases of MnO2 in nanodimensions and to evaluate their capacitance properties. Results of α-MnO2 prepared by a microemulsion route (α-MnO2(m)) are also used for comparison. Spherical particles of about 50 nm, nanorods of 30−50 nm in diameter, or interlocked fibers of 10−20 nm in diameters are formed, which depend on the crystal structure and the method of preparation. The specific capacitance (SC) measured for MnO2 is found to depend strongly on the crystallographic structure, and it decreases in the following order: α(m) > α ≅ δ > γ > λ > β. A SC value of 297 F g-1 is obtained for α-MnO2(m), whereas it is 9 F g-1 for β-MnO2. A wide (∼4.6 Å) tunnel size and large surface area of α-MnO2(m) are ascribed as favorable factors for its high SC. A large interlayer separation (∼7 Å) also facilitates insertion of cations in δ-MnO2 resulting in a SC close to 236 F g-1. A narrow tunnel size (1.89 Å) does not allow intercalation of cations into β-MnO2. As a result, it provides a very small SC.
Organ-specific context-sensitive CT image reconstruction and display (2018)

In this work, we present a novel method to combine mutually exclusive CT image properties that emerge from different reconstruction kernels and display settings into a single organ-specific image reconstruction and display. We propose a context-sensitive reconstruction that locally emphasizes desired image properties by exploiting prior anatomical knowledge. Furthermore, we introduce an organ-specific windowing and display method that aims at providing a superior image visualization. Using a coarse-to-fine hierarchical 3D fully convolutional network (3D U-Net), the CT data set is segmented and classified into different organs, e.g. the heart, vasculature, liver, kidney, spleen and lung, as well as into the tissue types bone, fat, soft tissue and vessels. Reconstruction and display parameters most suitable for the organ, tissue type, and clinical indication are chosen automatically from a predefined set of reconstruction parameters on a per-voxel basis. The approach is evaluated using patient data acquired with a dual source CT system. The final context-sensitive images simultaneously link the indication-specific advantages of different parameter settings and result in images joining tissue-related desired image properties. A comparison with conventionally reconstructed and displayed images reveals an improved spatial resolution in highly attenuating objects and air while maintaining a low noise level in soft tissue in the compound image. The images present significantly more information to the reader simultaneously and dealing with multiple volumes may no longer be necessary. The presented method is useful for the clinical workflow and bears the potential to increase the rate of incidental findings.
[Genetic testing for effective Herceptin therapy]. (2002)

Herceptin has provided the first proof that tyrosine kinase modulation, through monoclonal antibodies can translate into improved clinical outcomes in cancer therapy. The development of Herceptin was encouraged by the biologic significance of HER2 overexpression. Although the number of patients affected by the targeted molecular abnormality(30% of breast cancer patients) is small and the response rate observed in patients after treated with single agent Herceptin is rather low, the ability to document overexpression of the target in breast biopsies, and a growing interest in biologic therapy facilitated the rapid accrual of patients to clinical trials. The challenges of applying research techniques of molecular biology to routine clinical testing have been demonstrated by the experiences with the HER2/neu oncogene. Immunohistochemistry and fluorescence in situ hybridization yielded discrepant results regarding the frequency and degree of HER2 alterations even within the same sample. In order to make the complexity of interpretation of the discrepancy simple, it is wise to build an algorithm to help clinicians follow the ideal sequence of laboratory testings. The experience gained in the testing of Herceptin has provided important lessons for the future testing of molecularly targeted compounds.
Control of an electromechanical camless valve actuator (2003)

This paper addresses the modeling analysis and soft seating control of an electromagnetic actuator used in electromechanical camless valve-trains. Our mathematical modeling analysis reveals the instability of the actuator dynamics linearized around the seating position and zero velocity. This implies that an open loop pulse shaping alone cannot render repeatable valve closing and seating motions. Closed loop feedback control is necessary to generate repeatable motions that is insensitive to disturbances. A linear model is constructed based on a gray-box approach that combines mathematical modeling and system identification. Notch filtering and linear quadratic optimal control are designed and experimentally tested. The control performance is evaluated in terms of the closing time, valve seating velocity and seating tail-length, armature crossing velocity and armature seating velocity.
Plantes de Nouvelle-Calédonie. 124. Taxanes isolés des écorces de tronc d'Austrotaxus spicata (Taxacées) (1989)

International audience
Characterization of lignin-modifying enzymes of the selective white-rot fungus Physisporinus rivulosus (2007)

White-rot fungi are wood degrading organisms that are able to decompose all wood polymers; lignin, cellulose and hemicellulose. Especially the selective white-rot fungi that decompose preferentially wood lignin are promising for biopulping applications. In biopulping the pretreatment of wood chips with white-rot fungi enhances the subsequent pulping step and substantially reduces the refining energy consumption in mechanical pulping. Because it is not possible to carry out biopulping in industrial scale as a closed process it has been necessary to search for new selective strains of white-rot fungi which naturally occur in Finland and cause selective white-rot of Finnish wood raw-material. In a screening of 300 fungal strains a rare polypore, Physisporinus rivulosus strain T241i isolated from a forest burn research site, was found to be a selective lignin degrader and promising for the use in biopulping. \n\nSince selective lignin degradation is apparently essential for biopulping, knowledge on lignin-modifying enzymes and the regulation of their production by a biopulping fungus is needed. White-rot fungal enzymes that participate in lignin degradation are laccase, lignin peroxidase (LiP), manganese peroxidase (MnP), versatile peroxidase (VP) and hydrogen peroxide forming enzymes. In this study, P. rivulosus was observed to produce MnP, laccase and oxalic acid during growth on wood chips. In liquid cultures manganese and veratryl alcohol increased the production of acidic MnP isoforms detected also in wood chip cultures. Laccase production by P. rivulosus was low unless the cultures were supplemented with sawdust and charred wood, the components of natural growth environment of the fungus. \n\nIn white-rot fungi the lignin-modifying enzymes are typically present as multiple isoforms. In this study, two MnP encoding genes, mnpA and mnpB, were cloned and characterized from P. rivulosus T241i. Analysis of the N-terminal amino acid sequences of two purified MnPs and putative amino acid sequence of the two cloned mnp genes suggested that P. rivulosus possesses at least four mnp genes. The genes mnpA and mnpB markedly differ from each other by the gene length, sequence and intron-exon structure. In addition, their expression is differentially affected by the addition of manganese and veratryl alcohol. P. rivulosus produced laccase as at least two isoforms. The results of this study revealed that the production of MnP and laccase was differentially regulated in P. rivulosus, which ensures the efficient lignin degradation under a variety of environmental conditions.
A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis (2013)

ClinicalTrials.gov, http://clinicaltrials.gov/, NCT00716547.
Pick-by-Vision: An Augmented Reality supported Picking System (2009)

Order picking is one of the most important process steps in logistics. Because of their flexibility human beings\ncannot be replaced by machines. But if workers in order picking systems are equipped with a head-mounted\ndisplay, Augmented Reality can improve the information visualization.\nIn this paper the development of such a system – called Pick-by-Vision - is presented. The system is evaluated in\na user study performed in a real storage environment. Important logistics figures as well as subjective figures\nwere measured. The results show that Pick-by-Vision can improve considerably order picking processes.
STUDIES ON POSTTRANSFUSION AND DISSOCIATED FACTOR VIII AND IN PATIENTS WITH VON WILLEBRAND'S DISEASE (1977)

A B S T RA C T In normal plasma, the ratio of the procoagulant activity of factor VIII (VIIIAHF) to that of the von Willebrand factor activity (ristocetin cofactor, VIIIVwF) or factor VIII antigen (VIIIAGN) is -1, but ratios >1 (e.g., VIIIAHF > VIIIVwF or VIIIAGN) may be observed in some patients with von Willebrand's disease and in the posttransfusion plasmas of patients with this disorder. The lability of VIIIAHF was studied by incubating plasma, diluted 1:10 in imidazole buffer pH 7.1, for 6 h at 37°C. With normal plasmas, 77+12% (SD) of the original VIIIAHF activity remained after incubation. VIIIAHF was labile (e.g., 35-55% residual activity) in the posttransfusion plasmas (VIIIAHF> VIIIVwF) of a patient with von Willebrand's disease, but not in the early posttransfusion plasmas (VIIIAHF VIIIVwF). VIIIAHF was also labile in the (base-line) plasmas of three patients with von Willebrand's disease in whom the ratios of VIIIAHF to VIIIVWFwere 4.4 to 8.1, but not in the plasmas of four other patients in whom the ratio was 1. The electrophoretic mobility of factor VIII antigen was increased in two ofthe three patients with labile VIIIAHF. In both of these patients, and in the late posttransfusion plasmas, labile VIIIAHF activity could be stabilized by the addition of purified von Willebrand factor (lacking VIIIAHF activity) or by hemophilic plasma, but not by plasmas of patients with severe von Willebrand's disease. Thus, VIIIVwF may serve to stabilize VIIIAHF and this might explain the posttransfusion findings in von Willebrand's disease.
An olfactometer for measuring the repellent effect of chemicals on the stable fly <i>Stomoxys calcitrans</i> (L.) (1985)

Abstract An olfactometer is described that permits the evaluation of chemicals acting in the vapour phase against the stable fly Stomoxys calcitrans (L.). Hungry flies, held in a metal frame cage covered with soft gauze, are attracted to a target held adjacent to one side of the cage, and emitting an attractive airflow. Flies landing on the target are counted at intervals of 15s. Flies starved for 24h were tested in the olfactometer when 2, 3 and 4 days old. With the exception of the first exposure of the 4‐day‐old flies, all the flies of the three ages showed greater than 80% attraction to the olfactometer target after exposure for 2 min, for each of four successive exposures at 10‐min intervals. For all ages there was a significant increase in attraction at the second exposure but no further increase with subsequent exposures. It is likely that the sensillae, stimulated by the first exposure, subsequently responded faster. Eight chemicals were incorporated into the airflow behind the target to test their effect on flies. Permethrin (a low vapour pressure pyrethroid) and crotoxyphos (a low vapour pressure organophosphate) did not act in the vapour phase. Empenthrin (a high vapour pressure pyrethroid) and dichlorvos (a high vapour pressure organophosphate) both exhibited the toxic effect of knock‐down on the flies without repellency. Oil of citronella and citronellol, two known fly repellents, gave a general reduction of attraction that was dose dependent; fewer flies found the target and those that did stayed a shorter length of time. Natural pyrethrum gave a similar effect to these two at lower concentrations, but at higher concentrations, it also showed a repellent effect. N , N ‐Diethyl‐ m ‐toluamide gave a low reduction in attraction. The olfactometer shows potential for use with other flying insects, both to observe the effects of an insecticide and also to study the behavioural responses in the absence of insecticides.
A Review of the Association Between Parkinson Disease and Malignant Melanoma (2016)

Although a link between PD and melanoma exists, the etiology of this link continues to be elusive. Both PD and melanoma are likely multifactorial diseases involving genetic and environmental risk factors.
Using dual‐energy x‐ray imaging to enhance automated lung tumor tracking during real‐time adaptive radiotherapy (2015)

This study has highlighted the influence of patient anatomy on the success rate of real-time markerless tumor tracking using dual-energy imaging. Additionally, the importance of the spectral separation of the imaging beams used to generate the dual-energy images has been shown.
Detecting energy bugs and hotspots in mobile apps (2014)

Over the recent years, the popularity of smartphones has increased dramatically. This has lead to a widespread availability of smartphone applications. Since smartphones operate on a limited amount of battery power, it is important to develop tools and techniques that aid in energy-efficient application development. Energy inefficiencies in smartphone applications can broadly be categorized into energy hotspots and energy bugs. An energy hotspot can be described as a scenario where executing an application causes the smartphone to consume abnormally high amount of battery power, even though the utilization of its hardware resources is low. In contrast, an energy bug can be described as a scenario where a malfunctioning application prevents the smartphone from becoming idle, even after it has completed execution and there is no user activity. In this paper, we present an automated test generation framework that detects energy hotspots/bugs in Android applications. Our framework systematically generates test inputs that are likely to capture energy hotspots/bugs. Each test input captures a sequence of user interactions (e.g. touches or taps on the smartphone screen) that leads to an energy hotspot/bug in the application. Evaluation with 30 freely-available Android applications from Google Play/F-Droid shows the efficacy of our framework in finding hotspots/bugs. Manual validation of the experimental results shows that our framework reports reasonably low number of false positives. Finally, we show the usage of the generated results by improving the energy-efficiency of some Android applications.
CO2 Capture and Crystallization of Ammonia Bicarbonate in a Lab-Scale Scrubber (2018)

A lab-scale bubble-column scrubber is used to capture CO2 gas and produce ammonia bicarbonate (ABC) using aqueous ammonia as an absorbent under a constant pH and temperature. The CO2 concentration is adjusted by mixing N2 and CO2 in the range of 15–60 vol % at 55 °C. The process variables are the pH of the solution, temperature, gas-flow rate and the concentration of gas. The effects of the process variables on the removal efficiency (E), absorption rate (RA) and overall mass-transfer coefficient (KGa) were explored. A multiple-tube mass balance model was used to determine RA and KGa, in which RA and KGa were in the range of 2.14 × 10−4–1.09 × 10−3 mol/(s·L) and 0.0136–0.5669 1/s, respectively. Results found that, RA showed an obvious increase with the increase in pH, inlet gas concentration and gas temperature, while KGa decreased with an increase in inlet gas concentration. Using linear regression, an empirical expression for KGa/E was obtained. On the other hand, ammonia bicarbonate crystals could be produced at a pH of 9.5 when the gas concentration was higher than 30% and γ (=Fg/FA, the gas-liquid molar flow rate ratio) ≥ 1.5.
Legal Externships: Can They Be Valuable Clinical Experiences for Law Students? (1987)

The case method of instruction has dominated American legal education for more than a century.
The Akt1 Isoform Is Required for Optimal IFN-β Transcription through Direct Phosphorylation of β-Catenin (2012)

IFN-β is a critical antiviral cytokine that is capable of modulating the systemic immune response. The transcriptional induction of IFN-β is a highly regulated process, involving the activation of pattern recognition receptors and their downstream signaling pathways. The Akt family of serine/threonine kinases includes three isoforms. The specific role for the individual Akt isoforms in pattern recognition and signaling remains unclear. In this article, we report that the TLR3-mediated expression of IFN-β is blunted in cells that lack Akt1. The expression of IFN-β-inducible genes such as CCL5 and CXCL10 was also reduced in Akt1-deficient cells; the induction of TNF-α and CXCL2, whose expression does not rely on IFN-β, was not reduced in the absence of Akt1. Macrophages from Akt1(-/-) mice displayed deficient clearance of HSV-1 along with reduced IFN-β expression. Our results demonstrate that Akt1 signals through β-catenin by phosphorylation on Ser(552), a site that differs from the glycogen synthase kinase 3 β phosphorylation site. Stimulation of a chemically activated version of Akt1, in the absence of other TLR3-dependent signaling, was sufficient for accumulation and phosphorylation of β-catenin at Ser(552). Taken together, these results demonstrate that the Akt1 isoform is required for β-catenin-mediated promotion of IFN-β transcription downstream of TLR3 activation.
DeepFix: Fixing Common C Language Errors by Deep Learning (2017)

The problem of automatically fixing programming errors is a very active research topic in software engineering. This is a challenging problem as fixing even a single error may require analysis of the entire program. In practice, a number of errors arise due to programmer's inexperience with the programming language or lack of attention to detail. We call these common programming errors. These are analogous to grammatical errors in natural languages. Compilers detect such errors, but their error messages are usually inaccurate. In this work, we present an end-to-end solution, called DeepFix, that can fix multiple such errors in a program without relying on any external tool to locate or fix them. At the heart of DeepFix is a multi-layered sequence-to-sequence neural network with attention which is trained to predict erroneous program locations along with the required correct statements. On a set of 6971 erroneous C programs written by students for 93 programming tasks, DeepFix could fix 1881 (27%) programs completely and 1338 (19%) programs partially.
Movements of monosaccharides between blood and tissues of vascularly perfused small intestine. (1979)

1. A method involving the analysis of pulse transients of the vascular concentrations of test sugar and extracellular marker has been used to study the movements of non-metabolized sugars between the cells and vascular fluid of the vascularly perfused small intestine of R. ridibunda. Reasons are given for supposing that the method does properly measure the net entry of sugars into a cellular compartment that includes at least the epithelium. 2. It is found that while the glucose analogues, 3-O-methyl-D-glucose (3MG) and 2-deoxy-D-glucose (2)DG) are able to enter a cellular compartment when they are added to the vascular bed, alpha-methyl-D-glucoside (alpha MG) is able to enter the compartment only at a very slow rate from the vascular bed. In contrast, 3MG and alaph MG are well absorbed from the lumen whereas the inward permeability of 2DG across the lumen face of the epithelium is very low and, unlike 3MG and alpha MG, is not influenced by the presence in the lumen of other transported sugars. 3. The presence of phlorizin in the intestinal lumen increases the flux of alpha MG and of 3MG in the direction vascular bed--bulk phase of lumen. Reasons are given for supposing that the movement of sugars from the vascular bed into the lumen may involve a cellular route but occurs, at least in part, through a paracellular, extracellular route. 4. The exit of monosaccharides that have been loaded previously into the epithelium either from the lumen or from the vascular bed has been investigated. 3MG washes out rapidly into the vascular bed and the exit is stimulated by the addition of D-glucose to the intestinal lumen and by the addition of 2DG, but not alpha MG, to the arterial infusate. In contrast, alpha MG, loaded into the epithelium from the lumen, washes out of the cells only slowly into the vascular bed, so that even with high rates of vascular perfusion alpha MG accumulates within the tissue. The sustained accumulation of alpha MG implies that not only is the permeability for exit into the blood restricted for this sugar, but also the permeability is low across the brush border in an outward direction, cell to lumen ('lobster pot effect'). The wash-out of 3MG into the vascular effluent is sufficently rapid that only in the absence of vascular perfusion is 3MG accumulated within the tissue. 5. The contrasting properties of the monosaccharide transport systems accessible from the intestinal lumen and the vascular bed respectively are discussed in relation to the problems of epithelial transport of monosaccharide.
Measurement of the methyl radical concentration profile in a hot-filament reactor (1995)

The spatial profile of methyl radical concentration in a hot-filament reactor has been measured using cavity ring-down spectroscopy (CRDS) at a wavelength of 213.9 nm for which the CH3 absorption cross section has been shown to be nearly independent of temperature. Methyl radicals are generated with a 25 mm long tungsten filament heated to 2400 K in a slowly flowing mixture of 0.6% CH4 in H2 (20 Torr total pressure). CRDS is employed to measure CH3 absorbance as a function of a distance perpendicular to the axis of the filament. The CH3 absorbance profiles do not change when the direction of the process gas flow through the reactor is reversed, which indicates cylindrical symmetry of the CH3 distribution about the filament. Consequently, the radial CH3concentration in the reactor is determined by Abel inversion of the CH3 absorbance profile. The CH3concentration peaks ∼4 mm from the filament (1.04×1014molecules/cm3). Methyl radicals decay rapidly as a function of a distance from the filament and disappear about 2 cm from the filament within our present detection sensitivity (3×1012molecules/cm3).
Timing of FSH administration for ovarian stimulation in normo-ovulatory women: comparison of an early or a mid follicular phase initiation of a short-term treatment (2006)

Preventing the closure of the FSH window by mid to late follicular phase FSH administration better fulfils the objective of obtaining a limited number of large follicles than surpassing the FSH threshold by an early administration.