gebhart/patrepeval huggingface dataset:
Synthesis and Evaluation of Dipeptide Amides Containing N<sup>ω</sup>-Nitroarginine and D-2, 4-Diaminobutyric Acids as Inhibitors of Neuronal Nitric Oxide Synthase (2001)

Selective inhibition of the isoforms of nitric oxide synthase (NOS) could be beneficial in the treatment of certain disease states arising from the overproduction of nitric oxide by NOS. Recently, we reported dipeptide amides containing a basic amine side chain as potent and selective inhibitors of neuronal NOS (Huang H. et al. (1999) J. Med. Chem., 42, 3147). The most potent nNOS inhibitor among these compounds is L-ArgNO2-L-Dbu-NH2 (1) (Ki = 130 nM), which also exhibits the highest selectivity over eNOS (> 1500-fold). The D,D-dipeptide, D-Lys-D-ArgNO2-NH2 (3) also shows high potency and selectivity. Here the dipeptide amides containing ArgNO2 and D-Dbu (9-12) were synthesized and evaluated. They are all modest inhibitors of nNOS, but poor inhibitors of eNOS and iNOS. D-Dbu-D-ArgNO2-NH2 (12) exhibits decreased inhibitory potency as compared with 3. A hypothesis regarding the binding at the active site of nNOS is proposed to explain the potency differences between the L- and D-form dipeptide amides.
Comparative Analysis of Technologies for Treatment of Solid Radioactive Waste of Nuclear Power Plants - 11470 (2011)

A comparative evaluation and analysis of the effectiveness of three options for treating solid radioactive waste from nuclear power plants have been carried out. Throughput calculations have been performed for treating 2,000 cubic meters of waste per year. Two options include combinations of radioactive waste compaction with incineration of combustible waste and cementing ash residue. The third option is based on the shaft plasma-pyrolytic technology for treatment of solid radioactive waste, designed in SIA Radon, Moscow. The economic and environmental advantages of using the shaft plasma technology for treatment of radioactive waste from NPPs are shown.
Comparison of Machining with Long-Pulse Green and Ultrashort Pulse Lasers (2001)

(1) LLNL measured the material removal rate from stainless steel, silicon carbide, rhenium, N5, hastalloy X, and titanium as a function of pulse fluence at a wavelength of 810 nm for pulse durations of 150 fs, 1.5 ps, 20 ps, and 500 ps. The spot size of the beam used was 150 microns in diameter and the nominal material thickness was 1-2 mm. These experiments were performed on the existing 1 kHz laser system. Holes of different penetration depths were obtained to ascertain change in removal rate as a function of depth. Measurements included electron microscopy of selected samples. (2) The experiments in I were repeated for all materials but select pulse durations with the sample in a vacuum of base pressure 10 mTorr to determine if hole quality and ablation rate is improved. (3) LLNL measured material removal rate from stainless steel, silicon carbide, rhenium, N5, hastalloy X, and titanium as a function of pulse fluence at a wavelength of 532 nm for pulse duration at 200 ns. The spot size of the beam used was 200 microns in diameter and the material thickness was the same as in task I. Holes of different penetration depths were obtained to ascertain changes in removal rate as a function of depth.
New applications of cross-talk-based capacitance measurements [CMOS ICs] (2005)

Charge-based capacitance measurements (CBCMs) are widely used to estimate on-chip wiring capacitances because of their accuracy and simplicity. Enhanced CMOS transducers for CBCM have been recently proposed that exploit cross-talk to selectively measure cross-coupling capacitances. In this paper, we propose two new applications of cross-talk-based capacitance measurements: mismatch measurement of stacked metal-metal capacitor pairs, and localization of wire interruptions. We present the measurement techniques, we discuss their implementation and we report preliminary experimental results.
Production of Native-Type <i>Streptoverticillium mobaraense</i> Transglutaminase in <i>Corynebacterium glutamicum</i> (2003)

We previously observed secretion of active-form transglutaminase in Corynebacterium glutamicum by coexpressing the subtilisin-like protease SAM-P45 from Streptomyces albogriseolus to process the prodomain. However, the N-terminal amino acid sequence of the transglutaminase differed from that of the native Streptoverticillium mobaraense enzyme. In the present work we have used site-directed mutagenesis to generate an optimal SAM-P45 cleavage site in the C-terminal region of the prodomain. As a result, native-type transglutaminase was secreted.
Magnetic nanoparticle-based gyroscopic detection device: A review (2016)

Magnetic nanoparticles are suspended and spun in a controlled magnetic field. The angular position and inertia are inferred if an external force is applied to the system. The particles can be treated as a multitude of miniature gyroscopes whose overall affect can be combined as one single gyroscope. This article details the test setup and strategy to verify the feasibility of the whole detection system. Solution composition and oscillation frequency were varied to attempt to optimize the gyroscopic feedback.
Simultaneous inhibition of key growth pathways in melanoma cells and tumor regression by a designed bidentate constrained helical peptide (2014)

Protein-protein interactions are part of a large number of signaling networks and potential targets for drug development. However, discovering molecules that can specifically inhibit such interactions is a major challenge. S100B, a calcium-regulated protein, plays a crucial role in the proliferation of melanoma cells through protein-protein interactions. In this article, we report the design and development of a bidentate conformationally constrained peptide against dimeric S100B based on a natural tight-binding peptide, TRTK-12. The helical conformation of the peptide was constrained by the substitution of α-amino isobutyric acid--an amino acid having high helical propensity--in positions which do not interact with S100B. A branched bidentate version of the peptide was bound to S100B tightly with a dissociation constant of 8 nM. When conjugated to a cell-penetrating peptide, it caused growth inhibition and rapid apoptosis in melanoma cells. The molecule exerts antiproliferative action through simultaneous inhibition of key growth pathways, including reactivation of wild-type p53 and inhibition of Akt and STAT3 phosphorylation. The apoptosis induced by the bidentate constrained helix is caused by direct migration of p53 to mitochondria. At moderate intravenous dose, the peptide completely inhibits melanoma growth in a mouse model without any significant observable toxicity. The specificity was shown by lack of ability of a double mutant peptide to cause tumor regression at the same dose level. The methodology described here for direct protein-protein interaction inhibition may be effective for rapid development of inhibitors against relatively weak protein-protein interactions for de novo drug development.
Clinical Trials of Rotavirus Vaccines in Europe (2006)

Clinical trials of a live oral candidate rotavirus vaccine were started in 1982 and soon demonstrated that severe rotavirus disease can be prevented by vaccination. The first bovine candidate vaccine was withdrawn because of inconsistent efficacy, and studies of a rhesus rotavirus vaccine were initiated. A field trial of rhesus-human reassortant tetravalent rotavirus vaccine in Finland was pivotal for the licensure of this vaccine (RotaShield) in the United States in 1998. However, this vaccine was withdrawn in 1999 because of association with intussusception. Safety therefore became a major issue in the development of new candidate rotavirus vaccines. A pentavalent bovine-human reassortant rotavirus vaccine (RotaTeq) showed about 70% efficacy against any rotavirus disease and 100% efficacy against severe disease in Finland, according to the Clark scale. A large, multinational safety trial indicated no association of this vaccine with intussusception, and its licensure is under review in the EU. An attenuated human rotavirus vaccine (RIX4414; Rotarix) was developed from G1 rotavirus strain 89-12. A trial in Finland showed efficacy comparable with that of RotaShield, and a larger trial is under way in several European countries. In the first epidemic season, vaccine efficacy was 73% against any and 90% against severe rotavirus (mostly G1) gastroenteritis, according to the Vesikari scale. A large scale safety trial, conducted in Latin America plus Finland, indicated no increased risk of intussusception among recipients of Rotarix compared with placebo. The licensure of Rotarix is in process in the European Union.
Electroluminescence and space charge in polymeric insulation (2002)

The electroluminescence detection technique was used to determine the light emitted from cross-linked polyethylene (XLPE) cable insulation under high ac fields in high vacuum and pressurized nitrogen. It is shown that unlike the tests in pressurized gas, which always result in a light emission from inside XLPE specimen, the tests in vacuum can lead to light emission from the specimen surface, some distance away from the highest electric field inside the sample. Since the intensity of light emitted from the specimen surface can be significantly higher than the intensity of EL inside the specimen, care must be taken when selecting the experimental conditions for electroluminescence experiments and during interpretation of the test results.
Development of PCR-ELISA for Detection and Differentiation of<i>Didymella bryoniae</i>from Related<i>Phoma</i>species (2002)

The causal agent of gummy stem blight, Didymella bryoniae, often is isolated from infected cucurbits together with other Phoma spp. Polymerase chain reaction (PCR) primers specific to D. bryoniae and Phoma were used to develop and evaluate a microtiter-based PCR-enzyme-linked immunosorbent assay (ELISA) technique. Primers were modified by addition of a fluorescein and a biotin label to the 5' ends of the forward and reverse primers, respectively. After amplification, PCR products were detected in an ELISA using horseradish peroxidase-conjugated antifluorescein antibody and three substrates that yielded three colored products, one for each fungal group. The most sensitive substrate (highest signal:noise ratio) was 2,2' -azino-bis[3-ethylbenz-thiazoline-6-sulfonic acid]. PCR-ELISA successfully detected 45 of 46 D. bryoniae and all 13 Phoma isolates that were used. Results were comparable to those obtained with gel electrophoresis. Only one D. bryoniae isolate could not be detected with PCR-ELISA; this isolate also produced a fragment larger than other D. bryoniae isolates on agarose gels. PCR-ELISA was used successfully on crude extracts of "blind" fungal samples and identified seven of seven isolates as D. bryoniae or Phoma. Although less sensitive than gel electrophoresis, PCR-ELISA was a highly specific, yet simple, rapid and convenient assay for detection of D. bryoniae and Phoma sp.
Analysis of intrachannel nonlinear effects in highly dispersed optical pulse transmission (2000)

We analyze intrachannel nonlinear effects in high-bit-rate transmission systems based on short optical pulses that are dispersion compensated. We perform an analytical study of a generic example with two pulses, in which case the nonlinearity shifts the pulses in time and results in the generation of leading and trailing pulse echoes. We show that in all the relevant range of parameters, the magnitude of the nonlinear impairments reduces monotonically with the reduction of pulse width and with the increase of the dispersion coefficient.
Competition Between Transverse And Axial Hydraulic Fractures In Horizontal Wells (2013)

Abstract Most horizontal wells in unconventional reservoirs are drilled in the direction of the minimum stress. The preferred far-field fracture orientation thus favors hydraulic fractures transverse to the wellbore. The near-wellbore stress concentration, however, sometimes favors the initiation of fractures in a plane defined by the well axis. Transverse and axial hydraulic fractures can thus both initiate in some situations and cause significant near-wellbore tortuosity. We investigate the competition between these two types of fractures by comparing their energy requirement during hydraulic fracture initiation and propagation. First, we investigate the limiting cases of slow and fast pressurization where fluid flow and fracture mechanics uncouple. We then use recently developed numerical models for the initiation and propagation of hydraulic fractures from an open hole accounting for fluid flow in the newly created crack, wellbore stress concentration and injection system compressibility. Compared to a simple tensile stress analysis, the methodology described here provides a way to quantify the occurrence of only transverse or both transverse and axial hydraulic fractures as well as the maximum length of the axial fractures in the latter case. Based on dimensional analysis and numerical simulations for a range of relevant formation properties and far-field stress conditions, our results show that the critical defect length that favors transverse fracture over longitudinal is less than a borehole radius in the slow pressurization limit. For realistic injection conditions, if the initial defect length favors axial fractures, the distance over which transverse fractures become energetically favorable can become much larger than its slow pressurization value, especially for large dimensionless viscosity. Smaller pressurization rate and less viscous fluid ultimately favor the propagation of transverse fractures compared to axial ones.
Multilevel intelligent universal transformer for medium voltage applications (2005)

The solid-state transformer allows add-on intelligence to enhance power quality compatibility between source and load. It is desired to demonstrate the benefits gained by the use of such a device. Recent advancement in semiconductor devices and converter topologies facilitated a newly proposed intelligent universal transformer (IUT), which can isolate a disturbance from either source or load. This paper describes the basic circuit and the operating principle for the multilevel converter based IUT and its applications for medium voltages. Various power quality enhancement features are demonstrated with computer simulation for a complete IUT circuit.
Prospective correction of patient‐specific respiratory motion in myocardial T<sub>1</sub> and T<sub>2</sub> mapping (2020)

Patient-specific respiratory PROCO method significantly reduced the spatial variation of myocardial T<sub>1</sub> and T<sub>2</sub> mapping, while allowing for 100% efficient free-breathing acquisitions.
Overexpression of Protective Antigen as a Novel Approach To Enhance Vaccine Efficacy of<i>Brucella abortus</i>Strain RB51 (2000)

Brucella abortus strain RB51 is an attenuated rough strain that is currently being used as the official live vaccine for bovine brucellosis in the United States and several other countries. We reasoned that overexpression of a protective antigen(s) of B. abortus in strain RB51 should enhance its vaccine efficacy. To test this hypothesis, we overexpressed Cu/Zn superoxide dismutase (SOD) protein of B. abortus in strain RB51. This was accomplished by transforming strain RB51 with a broad-host-range plasmid, pBBR1MCS, containing the sodC gene along with its promoter. Strain RB51 overexpressing SOD (RB51SOD) was tested in BALB/c mice for its ability to protect against challenge infection with virulent strain 2308. Mice vaccinated with RB51SOD, but not RB51, developed antibodies and cell-mediated immune responses to Cu/Zn SOD. Strain RB51SOD vaccinated mice developed significantly (P < 0.05) more resistance to challenge than those vaccinated with strain RB51 alone. The presence of the plasmid alone in strain RB51 did not alter its vaccine efficacy. Also, overexpression of SOD did not alter the attenuation characteristic of strain RB51.
SHIPBOARD NAVIGATIONAL RADAR AS AN OIL SPILL TRACKING TOOL1 (1989)

ABSTRACT The utility of shipboard navigational radar as an oil spill tracking tool was evaluated in a wide range of sea states during an intentional oil spill exercise off Nova Scotia in September 1987. Specially tuned ship's radar onboard the Canadian Coast Guard Cutter Mary Hitchens was able to detect slicks of five barrels of spilled crude oil during periods of fog, rain, and darkness. Slicks were detectable in winds ranging from less than 10 knots up to more than 30 knots. There appeared to be a correlation between slick thickness and the capability for radar detection. This paper explores the observed limits of radar for detection during the exercise.
Ethylene polymerization with supported bis(triphenylsilyl) chromate catalysts (1972)

Abstract Bis(triphenylsilyl) chromate is an active catalyst for ethylene polymerization without further treatment or additives. Catalytic activity is markedly increased when the compound is deposited on silica–alumina and is further increased if it is deposited on silica and then treated with an aluminum alkyl. Polymer molecular weight can be controlled by reaction temperature, hydrogen addition, support type, and reducing agent structure to give polymers ranging in melt index from essentially zero to > 100. In the supported catalysts the bis(triphenylsilyl) chromate appears to be bound to the support and to undergo a reduction step either by reaction with ethylene or with aluminum alkyl prior to polymerization. The active site is envisioned as chromium alkyl, bound to the support, with propagation occurring by insertion of the monomer into a CrC bond. Chain termination is by chain transfer to monomer.
Adaptive coded aperture imaging in the infrared: towards a practical implementation (2008)

An earlier paper [1] discussed the merits of adaptive coded apertures for use as lensless imaging systems in the thermal infrared and visible. It was shown how diffractive (rather than the more conventional geometric) coding could be used, and that 2D intensity measurements from multiple mask patterns could be combined and decoded to yield enhanced imagery. Initial experimental results in the visible band were presented. Unfortunately, radiosity calculations, also presented in that paper, indicated that the signal to noise performance of systems using this approach was likely to be compromised, especially in the infrared. This paper will discuss how such limitations can be overcome, and some of the tradeoffs involved. Experimental results showing tracking and imaging performance of these modified, diffractive, adaptive coded aperture systems in the visible and infrared will be presented. The subpixel imaging and tracking performance is compared to that of conventional imaging systems and shown to be superior. System size, weight and cost calculations indicate that the coded aperture approach, employing novel photonic MOEMS micro-shutter architectures, has significant merits for a given level of performance in the MWIR when compared to more conventional imaging approaches.
Solid-state gas sensors for high temperature applications – a review (2014)

High temperature gas sensors for combustion processes are essential to improve energy efficiency and reduce toxic emissions.
Structure-based design, synthesis by click chemistry and <i>in vivo</i> activity of highly selective A<sub>3</sub> adenosine receptor agonists (2015)

2-Arylethynyl derivatives of (N)-methanocarba adenosine 5'-uronamides are selective A<sub>3</sub>AR (adenosine receptor) agonists. Here we substitute a 1,2,3-triazol-1-yl linker in place of the rigid, linear ethynyl group to eliminate its potential metabolic liability. Docking of nucleosides containing possible short linker moieties at the adenine C2 position using a hybrid molecular model of the A<sub>3</sub>AR (based on the A<sub>2A</sub>AR agonist-bound structure) correctly predicted that a triazole would maintain the A<sub>3</sub>AR selectivity, due to its ability to fit a narrow cleft in the receptor. The analogues with various <i>N</i><sup>6</sup> and C2-aryltriazolyl substitution were synthesized and characterized in binding (K<sub>i</sub> at hA<sub>3</sub>AR 0.3 - 12 nM) and <i>in vivo</i> to demonstrate efficacy in controlling chronic neuropathic pain (chronic constriction injury). Among <i>N</i><sup>6</sup>-methyl derivatives, a terminal pyrimidin-2-yl group in <b>9</b> (MRS7116) increased duration of action (36% pain protection at 3 h) <i>in vivo</i>. <i>N</i><sup>6</sup>-Ethyl 5-chlorothien-2-yl analogue <b>15</b> (MRS7126) preserved <i>in vivo</i> efficacy (85% protection at 1 h) with short duration. Larger <i>N</i><sup>6</sup> groups, e.g. <b>17</b> (MRS7138, >90% protection at 1 and 3 h), greatly enhanced <i>in vivo</i> activity. Thus, we have combined structure-based methods and phenotypic screening to identify nucleoside derivatives having translational potential.
Design, implementation, and evaluation of optimizations in a just-in-time compiler (1999)

Article Design, implementation, and evaluation of optimizations in a just-in-time compiler Share on Authors: Kazuaki Ishizaki IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile , Motohiro Kawahito IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile , Toshiaki Yasue IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile , Mikio Takeuchi IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile , Takeshi Ogasawara IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile , Toshio Suganuma IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile , Tamiya Onodera IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile , Hideaki Komatsu IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile , Toshio Nakatani IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, Japan IBM Tokyo Research Laboratory, 1623-14, Shimotsuruma, Yamato, Kanagawa, 242-8502, JapanView Profile Authors Info & Claims JAVA '99: Proceedings of the ACM 1999 conference on Java GrandeJune 1999 Pages 119–128https://doi.org/10.1145/304065.304111Online:01 June 1999Publication History 69citation948DownloadsMetricsTotal Citations69Total Downloads948Last 12 Months28Last 6 weeks10 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access