gebhart/patrepeval huggingface dataset:
Architectures for Bit-Split String Scanning in Intrusion Detection (2006)

String matching is a critical element of modern intrusion detection systems because it lets a system make decisions based not just on headers, but actual content flowing through the network. Through careful codesign and optimization of an architecture with a new string matching algorithm, the authors show it is possible to build a system that is almost 12 times more efficient than the currently best known approaches.
High-speed performance of NpN InGaAsN-based double heterojunction bipolar transistors (2002)

We report the fabrication of double heterojunction bipolar transistors (DHBTs) with the use of a new quaternary InGaAsN material system that takes advantage of a low energy band gap in the base to reduce operating voltages in GaAs-based electronic devices. InGaP/In/sub 0.03/Ga/sub 0.97/As/sub 0.99/N/sub 0.01//GaAs DHBTs with improved band gap engineering at both heterojunctions exhibit a DC peak current gain over 16 with small active emitter area. The use of the InGaAsN base layer allows a significant reduction of the turn-on voltage by 250 mV for the new technology over a standard InGaP/GaAs HBT, while maintaining high-frequency characteristics with cut-off frequency and maximum oscillation frequency as high as 40 GHz and 70 GHz, respectively. This technology is promising for next generation RF circuits using GaAs-based HBTs by reducing the operating voltage for low power consumption and better handling of supply voltages in advanced wireless handsets.
Improvement on Recording Density in Reflection-type Holographic Memory with Random Phase Shift Multiplexing (2005)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text O. Matoba, Y. Yokohama, K. Nitta, and T. Yoshimura, "Improvement on Recording Density in Reflection-type Holographic Memory with Random Phase Shift Multiplexing," in Adaptive Optics: Analysis and Methods/Computational Optical Sensing and Imaging/Information Photonics/Signal Recovery and Synthesis Topical Meetings on CD-ROM, Technical Digest (Optica Publishing Group, 2005), paper ITuB5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
An Experimental and Theoretical Investigation of Double Resonance Activation in Electrostatic MEMS Resonators (2018)

Electrostatic micro-electro-mechanical-system (MEMS) devices show great potential in a variety of applications such as sensing and actuation; however, they are hindered by their high input voltage requirement. Double resonance excitation, which activates the system’s mechanical and electrical resonances simultaneously, was recently demonstrated experimentally to alleviate this problem. In this work, we present a mathematical model, based on the Euler Bernoulli beam model coupled with a circuit model, to simulate double resonance in MEMS devices and to shed light more onto the previously published experimental data. We show good agreement between the theoretical simulation and experimental data when the electrical resonance frequency band is sufficiently high.
Colorless FSK Demodulation and Detection With Integrated Fabry–Pérot-Type SOA/REAM (2010)

A receiver for optical frequency modulated signals, based on colorless demodulation and detection, is presented. An integrated combination of semiconductor optical amplifier (SOA) and reflective electroabsorption modulator (REAM) is designed to obtain a comb-like spectral detection function, replacing the typically required costly frequency discrimination filter. The spectral properties of the designed SOA/REAM chip are discussed and the reception of a 10-Gb/s optical frequency modulated downstream signal is demonstrated, proving the applicability as receiving optical subsystem in the customer premises equipment of fiber-to-the-home access networks with wavelength reuse for upstream transmission and no downstream crosstalk.
Storage characteristics of multiple‐donor pooled red blood cells compared to single‐donor red blood cell units (2016)

BACKGROUND Each unit of blood donated is processed and stored individually resulting in variability in the amount of red blood cells (RBCs) collected, RBC properties, and the 24‐hour posttransfusion RBC survivability. As a result, each unit differs in its ability to deliver oxygen and potentially its effects on the recipient. The goal of this study was to investigate the storage of pooled RBCs from multiple donors in comparison to control standard RBC units. STUDY DESIGN AND METHODS Two units of irradiated, leukoreduced RBCs of same ABO, D, E, C, and K antigen phenotype were collected from each of five donors using apheresis. One unit from each donor was pooled in a 2‐L bag and remaining units were used as controls. After being pooled, RBCs were separated in five bags and stored at 4°C along with the controls. Quality indexes were measured on Days 2, 14, and 28 for all the units. RESULTS Adenosine triphosphate assays for both pooled and controls showed a slight decrease from Day 2 to Day 28 (pooled/control from 5.22/5.24 to 4.35/4.33 µmol/g hemoglobin [Hb]). 2,3‐Diphosphoglycerate was successfully rejuvenated for all RBC units on Day 28 (pooled 11.46 µmol/g Hb; control 11.86 µmol/g Hb). The results showed a nonsignificant difference between pooled and control units, with a general trend of lower standard deviation for pooled units when compared to controls. CONCLUSION Pooled units have reduced unit‐to‐unit variability. Future exploration of their immunogenicity is required before using pooled units for transfusion.
An efficient and scalable postcomputation-based generic-point parallel scalar multiplication method (2014)

An efficient generic-point parallel scalar multiplication method is presented here where a new mapping technique is used with a modified version of the postcomputation-based method [6]. The results show that the proposed method outperforms that of the work in [6] when the number of consecutive requests is two or more. Furthermore, the results show that the proposed method is scalable for any number of parallel processors and performs better as the number of consecutive requests increases. This method consequently is very attractive for use in high-performance end servers that employ parallel elliptic curve processors.
Adhesive bonding of various materials to hard tooth tissues. IX. The concept of polyfunctional surface‐active comonomers (1975)

Abstract The concept of surface‐active comonomers of higher functionality is propsed as a means of increasing reliability of the bonding between preventive and restorative dental materials and tooth structures.
4 EFFECT OF A PROLONGED AROMATASE INHIBITOR TREATMENT ON PRE-OVULATORY OVARIAN FOLLICLES IN CATTLE (2011)

Letrozole, a non-steroidal aromatase inhibitor, prevents the body from producing its own oestrogen. The potential use of this compound for herd synchronization is supported by previous studies in which letrozole treatment increased mean plasma LH concentrations, prolonged the period of dominance of the extant dominant follicle and delayed emergence of the next follicular wave. Heifers given a 3-day regimen of letrozole exhibited greater corpus luteum diameter indicative of a luteotrophic effect. The objective of the present study was to test the hypothesis that letrozole treatment during the development of the preovulatory follicular wave will delay ovulation. Post-pubertal beef heifers were given 2 luteolytic doses of PGF (12 h apart) and monitored by ultrasonography for ovulation. Ovarian follicular wave emergence was synchronized by ultrasound-guided transvaginal follicular ablation 5 to 8 days after PGF-induced ovulation (Day –1 = follicular ablation, Day 0 = wave emergence) and a luteolytic dose of PGF was given 60 and 72 h later. On Day 1, heifers were divided randomly into 2 groups (n = 15/group) and given an intravaginal device containing 1 g of letrozole or a blank device (control). The intravaginal devices were removed on Day 7, or at the time of ovulation, whichever occurred first. The ovaries were monitored by ultrasonography and a blood sample was collected daily from day of ablation to 12 days post-ovulation. Single point measurements were analysed by t-tests and serial data were analysed by analysis of variance for repeated measures. Multiple contrasts were made by Tukey's test. The interval from placement of the intravaginal device to ovulation was longer in letrozole-treated animals (6.1 ± 0.25 vs 5.1 ± 0.26 days, P &lt; 0.01). Compared with controls, the day-to-day diameter profile of the dominant follicle of the ovulatory wave was larger (P &lt; 0.05) and the maximum diameter greater (14.6 ± 0.51 vs 12.4 ± 0.53 mm; P &lt; 0.01) in letrozole-treated heifers. The diameter profile of the corpus luteum formed post-letrozole treatment did not differ between groups; however, plasma P4 concentrations were higher (P &lt; 0.01) in heifers treated with letrozole. In summary, a slow-release intravaginal letrozole device delayed ovulation by 24 h and induced the formation of a corpus luteum that secreted higher levels of progesterone. A slow-release intravaginal letrozole device may become useful for the development of an aromatase inhibitor-based protocol to control ovulation for herd synchronization and to enhance fertility by increasing circulating progesterone concentrations during the first 7 days post-AI or embryo transfer in cattle. Supported by the Natural Sciences and Engineering Research Council of Canada and Bioniche Life Sciences Inc.
Large-scale synthesis of CexLa1−xF3 nanocomposite scintillator materials (2011)

Transparent nanocomposites have been developed which consist of nanocrystals embedded in an organic matrix. The materials are comprised of up to 60% by volume of 7–13 nm crystals of the phosphor CexLa1−xF3, and are greater than 70% transparent in the visible region at a thickness of 1 cm. Consistencies of the nanocomposites range from a solid polymer to a wax to a liquid, depending on the workup conditions of the nanoparticle synthesis. These transparent nanophosphor composite materials have potential applications in radiation detection as scintillators, as well as in other areas such as imaging and lighting, and can be produced on large scales up to near-kilogram quantities at near ambient conditions, much lower in temperature than typical nanoparticle syntheses.
Loss of calcineurin in the spinal dorsal horn contributes to neuropathic pain, and intrathecal administration of the phosphatase provides prolonged analgesia (2013)

Calcineurin (protein phosphatase 3) regulates synaptic plasticity in the brain. The development of neuropathic pain appears dependent on some of the same mechanisms that underlie brain synaptic plasticity. In this study, we examined whether calcineurin regulates chronic constriction injury (CCI)-elicited plasticity in the spinal dorsal horn. CCI animals exhibited mechanical and thermal hypersensitivity 7 days after ligation of the sciatic nerve. Neither control uninjured nor sham-operated animals exhibited pain behavior. Calcineurin activity and content of its Aα isoform were significantly decreased in the ipsilateral postsynaptic density (PSD) of dorsal horn neurons in CCI animals. Calcineurin activity and content in the contralateral PSD of CCI animals or either side of the dorsal horn in sham animals were not modified. The pain behavior in CCI animals was attenuated by intrathecal application of exogenous calcineurin. The treatment was long-lasting as a single injection provided analgesia for 4 days by restoring the phosphatase's activity and Aα content in the PSD. No signs of toxicity were detected up to 14 days after the single intrathecal injection. Intrathecal application of the calcineurin inhibitor FK-506 elicited pain behavior in control uninjured animals and significantly reduced calcineurin activity in the PSD. CCI may elicit neuropathic pain at least in part as a result of the loss of calcineurin-mediated dephosphorylation in the dorsal horn. Addition of the phosphatase by intrathecal injection reverses the injury-elicited loss and provides prolonged pain relief. Clinical therapy with calcineurin may prove to be a novel, effective, and safe approach in the management of well-established neuropathic pain.
Submicrosecond transient control for a forward-pumped Raman fiber amplifier (2005)

We propose and experimentally verify a new dynamic gain and tilt transient control technique for a multiwavelength forward-pumped Raman fiber amplifier. Using this technique, we demonstrate up to 7-dB static power excursion correction (to within 0.4 dB) and dynamic gain control with submicrosecond response.
Transient thermal properties of high-power diode laser bars (2006)

The transient thermal properties of high-power diode laser bars with active and passive cooling are analyzed. Both thermal imaging and the analysis of the thermal wavelength tuning behavior are employed to extract the device temperature as a function of time. A steady-state thermal situation is established with rise times of about 10 and 60ms for active and passive cooling, respectively. The latter number, however, is substantially increased by the particular properties of the external heat sink. Such results are confirmed by model calculations based on the finite element method.
Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B (2010)

We have generated high-affinity SEB-specific antibodies capable of neutralizing SEB in vitro as well as in vivo in a mouse model. Taken together, these results suggest that our antibodies hold the potential as passive immunotherapies for both prophylactic and therapeutic countermeasures of SEB exposure.
Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors (2006)

A series of (5-substituted pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidine (C5-Pro-Pro) analogues was discovered as dipeptidyl peptidase IV (DPPIV) inhibitors as a potential treatment of diabetes and obesity. X-ray crystallography data show that these inhibitors bind to the catalytic site of DPPIV with the cyano group forming a covalent bond with the serine residue of DPPIV. The C5-substituents make various interactions with the enzyme and affect potency, chemical stability, selectivity, and PK properties of the inhibitors. Optimized analogues are extremely potent with subnanomolar Ki's, are chemically stable, show very little potency decrease in the presence of plasma, and exhibit more than 1,000-fold selectivity against related peptidases. The best compounds also possess good PK and are efficacious in lowering blood glucose in an oral glucose tolerance test in ZDF rats.
Relative Occurrence of Flow Limitation and Snoring During Continuous Positive Airway Pressure Titration (1998)

While detection of snoring occasionally provided additional information, overall flow limitation was the earliest indicator of obstruction during decreases in CPAP.
Evolutionary Conservation of a Human Function‐Associated Molecule on Murine Natural Killer Cells: Expression and Function (1994)

Using a novel anti-natural killer (NK) cell monoclonal antibody (MoAb), we have recently identified an evolutionary conserved function-associated molecule (FAM) present on fish, rat and human NK cells. This molecule is involved in NK cell function as anti-FAM MoAbs inhibit cytotoxicity, stimulate lymphokine secretion and inhibit conjugate formation between effector cells and target cells. We now have examined murine NK cells for the presence of this structure. It was observed by two-colour flow cytometric analysis that the anti-FAM MoAb 5C6 specifically bound to a subpopulation of nylon wool non-adherent splenic lymphocytes (19-20%). The expression of the FAM molecule was restricted to NK cells that expressed the NK1.1 antigen. Neither T cells, B cells, nor macrophages reacted with the anti-FAM MoAb. Analysis of FAM expression in various lymphoid tissues revealed that splenocytes expressed the greatest numbers of MoAb(+) cells. Generation of lymphokine-activated killer (LAK) cells and adherent lymphokine-activated killer (ALAK) cells resulted in higher levels of FAM expression. The anti-FAM MoAb 5C6 also detected the presence of FAM on fresh SCID NK cells. It was demonstrated that the anti-FAM MoAb 5C6 inhibited the lysis of target cells by endogenous NK cells, activated NK cells, 5d LAK cells, ALAK cells and SCID NK cells. Moreover, conjugate assays demonstrated involvement of this molecule in recognition between NK cells and target cells.
Identification of Small Molecular Weight Inhibitors of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 (SHP-2) via in Silico Database Screening Combined with Experimental Assay (2008)

Virtual screening methods combined with experimental assays were used to identify low molecular weight inhibitors for Src homology 2 domain-containing phosphatase 2 (SHP-2) that is mutated and hyperactivated in Noonan syndrome and a significant portion of childhood leukemias. Virtual screening included multiple conformations of the protein, score normalization procedures, and chemical similarity considerations. As the catalytic core of SHP-2 shares extremely high homology to those of the related SHP-1 phosphatase and other tyrosine phosphatases, in order to identify selective inhibitors, we chose to target an adjacent protein surface pocket that is predicted to be important for binding to phosphopeptides and that has structural features unique to SHP-2. From a database of 1.3 million compounds, 9 out of 165 computationally selected compounds were shown to inhibit SHP-2 activity with IC(50) values of approximately 100 microM. Two of the active compounds were further verified for their ability to inhibit SHP-2-mediated cellular functions. Fluorescence titration experiments confirmed their direct binding to SHP-2. Because of their simple chemical structures, these small organic compounds have the potential to act as lead compounds for the development of novel anti-SHP-2 drugs.
Construction of a Geobacter Strain With Exceptional Growth on Cathodes (2018)

Insoluble extracellular electron donors are important sources of energy for anaerobic respiration in biogeochemical cycling and in diverse practical applications. The previous lack of a genetically tractable model microorganism that could be grown to high densities under anaerobic conditions in pure culture with an insoluble extracellular electron donor has stymied efforts to better understand this form of respiration. We report here on the design of a strain of <i>Geobacter sulfurreducens</i>, designated strain ACL, which grows as thick (ca. 35 μm) confluent biofilms on graphite cathodes poised at -500 mV (<i>versus</i> Ag/AgCl) with fumarate as the electron acceptor. Sustained maximum current consumption rates were >0.8 A/m<sup>2</sup>, which is >10-fold higher than the current consumption of the wild-type strain. The improved function on the cathode was achieved by introducing genes for an ATP-dependent citrate lyase, completing the complement of enzymes needed for a reverse TCA cycle for the synthesis of biosynthetic precursors from carbon dioxide. Strain ACL provides an important model organism for elucidating the mechanisms for effective anaerobic growth with an insoluble extracellular electron donor and may offer unique possibilities as a chassis for the introduction of synthetic metabolic pathways for the production of commodities with electrons derived from electrodes.
Triphenylboroxine and Triphenylborane as Anion Acceptors for Electrolyte in Fluoride Shuttle Batteries (2018)

For liquid-based fluoride shuttle batteries, electrolyte composed of organic solvent and supporting electrolyte salt is developed.To increase the solubility of supporting electrolyte salt in organic solvent, anion acceptors (triphenylboroxine or triphenylborane) are added.The addition of anion acceptor greatly increases the solubility of supporting electrolyte salt, and discharge-charge reaction of BiF3 electrode is confirmed in the prepared electrolytes.
Latest research and development of twin‐straight tube Coriolis mass flowmeters (2007)

Purpose The paper aims to theoretically predict sensor signals and calibration factors for twin‐straight tube Coriolis flowmeters. It also aims to determine an optimal flow path to minimize pressure loss. Design/methodology/approach Two major aspects involved in the latest research and development of a series of twin‐straight tube Coriolis mass flowmeters are presented. Firstly, the theoretical method adopted for the concept design to predict sensor signals and calibration factors is given. This is essentially a finite element method using the fluid structure interaction theory based on a Timoshenko beam coupled with one‐dimensional flow. Secondly, detailed design using computational fluid dynamics is described to optimise pressure loss. Finally, experimental results from testing a prototype meter are given and compared with the numerical results. Findings Finds that sensor signals and calibration factors can be predicted with the presented method. Also finds that pressure loss can be minimized with an optimized flow splitter. Practical implications Comparison between experiments and theoretical results shows agreement and indicates the effectiveness of computer‐aided engineering at an early development stage of Coriolis mass flow sensors. Originality/value Provide a theoretical model to predict sensor signals and calibration factors for Coriolis mass flowmeters. Introduce an optimized splitter shape for a twin tube configuration.
Multiband phase‐constrained parallel MRI (2013)

Multiband phase-constrained parallel MRI has the potential for accelerated multi-slice imaging with an improved SNR performance.
ChemInform Abstract: Catalysts for the Living Insertion Polymerization of Alkenes: Access to New Polyolefin Architectures Using Ziegler—Natta Chemistry (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Improvement in dynamic range limitation of swept source optical coherence tomography by true logarithmic amplification (2010)

We previously demonstrated, with both theoretical and experimental studies, the dynamic range limitation with spectral domain optical coherence tomography (OCT) relative to time domain OCT. A significant portion of this limitation was due to the difference of analog/digital conversion. In this paper, a new method of true logarithmic amplification is discussed theoretically and tested experimentally to increase the dynamic range of a swept source OCT. With the current experimental setup, an increase of the dynamic range by about 6 dB was obtained.
Single aperture monopulse horn antenna (2005)

This paper describes the design and performance of a conical Potter horn antenna which can generate sum or difference far field patterns suitable for monopulse tracking applications. The antenna consists of a horn antenna fed with a metal post loaded polarizer which is energised by suitably phased 50-/spl Omega/ matched coaxial probes. The prototype demonstrator designed here operates in the frequency range 8-8.6GHz with sum and difference patterns obtained by using a very simple phasing circuit. At 8.5GHz, the gain of the sum pattern is 18.6dB and the null in the difference pattern is 26dB at boresight.