gebhart/patrepeval huggingface dataset:
Newly Designed High Expansion Through-Tubing Bridge Plug Service to Reduce Operational Costs and Increase Reliability (2022)

Abstract Through-tubing bridge plug (TTBP) service is a common e-line well intervention service for isolating lower non-productive zones for improved production or plug and abandonment. Traditionally, this service was only run on e-line, as it requires a unique electro-mechanical extended stroke setting tool, to set these types of barriers. This paper discusses the challenges of developing a new design of the TTBP, deployed on Digital Slickline (DSL) to help optimize service costs. System-level analysis was adopted to analyze the current e-line TTBP service and identify challenges to DSL deployment. In general, these plugs have extremely high-expansion ratios (2x to 4x) compared to other wireline set barriers as they have to pass through tight downhole restrictions in the completion before passing into the casing. As a result, these plugs have an exceptionally long setting stroke, requiring a specific setting tool with high power demands. The high expansion ratio of the TTBP limits pressure rating and this type of barrier demands a cement cap on the plug to complete the intervention. DSL cannot send power from the surface; therefore, it has electrical power budget limitations. The right balance needs to be found between the stroke length and the available power to achieve a successful plug. The elastomer stack and the backup petal assembly were significantly redesigned to achieve an acceptable expansion ratio while minimizing stroke length. This feature allowed for the development of a battery-powered setting tool with a shorter stroke length. Running the service on DSL lets the operator confirm depth correlation before setting the plug and real-time feedback from downhole sensors to ensure an in-situ quality plug set. Moreover, digital slickline provides accurate bottom-hole temperature, which is critical in achieving a suitable cement plug. The paper will present results from field trials showing the cost savings of running these plugs on DSL compared to e-line.
Comparison of cathodoluminescence and photoluminescence of CdSeTe films grown on Si by molecular beam epitaxy (2004)

For the first time, cathodoluminescence of CdSexTe1-x (with x = 0-1) films grown by molecular beam epitaxy on (211) Si substrates were systematically studied and compared with photoluminescence. The Se mole fraction was consistently determined by x-ray rocking-curve diffraction, wavelength-dispersive spectroscopy, and Rutherford backscattering. The band gap energy, as determined by both cathodoluminescence and photoluminescence, was found consistent with literature. The band gap energy varied parabolically with composition as predicted by theory. The results suggest cathodoluminescence can be used to conveniently map composition fluctuations such as Se segregation in CdSe<sub>x</sub>Te<sub>1-x</sub> films, with higher spatial resolution than photoluminescence.
Anti-fibrotic effects of phenolic compounds on pancreatic stellate cells (2015)

Our findings suggest that the mentioned phenolic compounds may serve as anti-fibrotic agents in PSC-relating disorders and pathologies, particularly pancreatic fibrosis.
Nearfield acoustic holography: I. Theory of generalized holography and the development of NAH (1985)

Because its underlying principles are so fundamental, holography has been studied and applied in many areas of science. Recently, a technique has been developed which takes the maximum advantage of the fundamental principles and extracts much more information from a hologram than is customarily associated with such a measurement. In this paper the fundamental principles of holography are reviewed, and a sound radiation measurement system, called nearfield acoustic holography (NAH), which fully exploits the fundamental principles, is described.
Clockless Dynamic SFQ <sc>and</sc> Gate With High Input Skew Tolerance (2019)

We have introduced a new class of dc-powered Single Flux Quantum (SFQ) logic that uses dynamic (self-resetting) internal states to achieve completely clock-free gate operation and provide high immunity to input data skew. We call it DSFQ (dynamic SFQ) logic. We have successfully designed and tested a 2-input DSFQ and gate and showed its ability to hold dynamically its internal states for over 25 ps while operating at 10 GHz clock frequency. We also demonstrated picosecond-scale dynamics of DSFQ circuit with an on-chip Josephson sampler, with only low-speed interfaces required.
Sodium‐Ion‐Selective Two‐Photon Fluorescent Probe for In Vivo Imaging (2009)

Two photons are better than one: A two-photon probe (ANa1, see picture) shows strong two-photon fluorescence enhancement in response to Na+ and a dissociation constant (Kdi) of (26±2) mM in the cell. It can be easily loaded into the cells and can selectively detect intracellular free Na+ in live cells and living tissues at a depth of 100–200 μm for a long period of time. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Speech recognition modeling advances for mobile voice search (2011)

This paper reports on the development and advances in automatic speech recognition for the AT&T Speak4it <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> voice-search application. With Speak4it as real-life example, we show the effectiveness of acoustic model (AM) and language model (LM) estimation (adaptation and training) on relatively small amounts of application field-data. We then introduce algorithmic improvements concerning the use of sentence length in LM, of non-contextual features in AM decision-trees, and of the Teager energy in the acoustic front-end. The combination of these algorithms, integrated into the AT&T Watson recognizer, yields substantial accuracy improvements. LM and AM estimation on field-data samples increases the word accuracy from 66.4% to 77.1%, a relative word error reduction of 32%. The algorithmic improvements increase the accuracy to 79.7%, an additional 11.3% relative error reduction.
Poly(alkyl/aryloxothiazenes): inorganic polymers with a sulfur(VI)-nitrogen backbone. Synthesis, characterization, and theoretical calculations (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(alkyl/aryloxothiazenes): inorganic polymers with a sulfur(VI)-nitrogen backbone. Synthesis, characterization, and theoretical calculationsAroop K. Roy, Gary T. Burns, George C. Lie, and Stelian GrigorasCite this: J. Am. Chem. Soc. 1993, 115, 7, 2604–2612Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ja00060a009https://doi.org/10.1021/ja00060a009research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Distinct Differences in the Expansion and Phenotype of TB10.4 Specific CD8 and CD4 T Cells after Infection with Mycobacterium tuberculosis (2009)

Our results show that CD4 and CD8 T cells directed to epitopes in the same antigen differ both in their kinetics and functional characteristics throughout an infection with M. tuberculosis. In addition, the observed strong expansion of CD8 T cells in the late stages of infection could have implications for the development of post exposure vaccines against latent TB.
Dynamic body charge modulation for sense amplifiers in partially depleted SOI technology (2001)

We present a dynamic body charge modulation technique to improve the matching of CMOS device threshold voltage (V/sub t/) characteristics in the partially depleted silicon-on-insulator (SOI) technology. For a latch-type sense amplifier in the SRAM complementary bitline structure, a pair of-charging FETs are employed to bring the bodies of cross-coupled sensing devices to the voltage rail. In doing so, operating history-dependent body potential mismatches are eliminated for every access cycle. Body-contacted FETs are returned to their floating body states when the charging action is completed. This technique achieves repeatable low-V/sub t/ and high-performance operation simultaneously. The pulse signal controlling body charging is not constrained by a stringent timing requirement. Therefore, its effectiveness is insensitive to the body contact quality of sensing FETs. This technique demonstrates a significant leverage for high-performance RAM circuits. It also offers the advantages of speed and noise immunity in the low-voltage low-power operating regime.
Conversational programming (2013)

Our powerful computers help very little in debugging the program we have so we can change it into the program we want. We introduce Conversational Programming as a way to harness our computing power to inspect program meaning through a combination of partial program execution and semantic program annotation. A programmer in our approach interactively selects highly autonomous "agents" in a program world as conversation topics and then changes the world to explore the potential behaviors of a selected agent in different scenarios. In this way, the programmer proactively knows how their code affects program execution as they explore various contexts. This paper describes conversational programming through design principles and use cases.
Fault-tolerant architectures for continuous media servers (1996)

Continuous media servers that provide support for the storage and retrieval of continuous media data (e.g., video, audio) at guaranteed rates are becoming increasingly important. Such servers, typically, rely on several disks to service a large number of clients, and are thus highly susceptible to disk failures. We have developed two fault-tolerant approaches that rely on admission control in order to meet rate guarantees for continuous media requests. The schemes enable data to be retrieved from disks at the required rate even if a certain disk were to fail. For both approaches, we present data placement strategies and admission control algorithms. We also present design techniques for maximizing the number of clients that can be supported by a continuous media server. Finally, through extensive simulations, we demonstrate the effectiveness of our schemes.
Understanding the Stability of Aromatic Redox Shuttles for Overcharge Protection of Lithium-Ion Cells (2006)

Molecular orbital theory is employed to improve understanding of the stability of aromatic compounds as redox shuttles for overcharge protection of lithium-ion cells and batteries. The theoretical calculations clearly demonstrate that the interaction between the aromatic ring and the substitution groups is critical to maximize the stability of radical cations, which are generated when the aromatic redox shuttles are oxidized at the positive electrode. It is also demonstrated that the unsubstituted hydrogen atoms on the aromatic ring also contribute significantly to the instability of the radical cations. The model suggests that full substitution on the aromatic ring or protection of the H atoms with bulky groups is highly desirable for the stability of the redox shuttles. Using the calculation results as a guide, a novel stable redox shuttle with a redox potential of vs was developed. The preliminary experimental results show that lithium-ion cells incorporating this redox shuttle are robust to overcharge even at elevated temperatures.
Perceptually motivated binaural beamforming with cues preservation for hearing aids (2016)

In this contribution, a new binaural beamforming algorithm for hearing aids is introduced in order to generate binaural outputs with a good trade-off between noise reduction and binaural noise cues preservation. This includes cues preservation for the directional noise sources as well as diffuse-like background noise. The new algorithm is based on selection and mixing processes in the Time-Frequency domain (T-F) and is applicable for realistic T-F decompositions. The selection and mixing are done with a classification algorithm based on the complex coherence between the standard beamformer outputs and other available signals. To validate the performance of the proposed algorithm, simulations have been performed using recorded signals provided by a hearing aid manufacturer. The results indicate that the proposed algorithm can provide a good trade-off between noise reduction and binaural noise cues preservation, even for complex acoustic environments.
A novel approach to automatic protection switching using trees (2002)

We propose a new algorithm for constructing redundant trees over any edge or node-redundant network in order to perform automatic protection switching in the presence of edge or node failures. Existing redundancy schemes and their topological requirements are reviewed. We describe our algorithm and give an overview of its essential properties. The algorithm is polynomial in the number of nodes. We present an example of the construction of a lowest cost redundant topology for a given configuration and of the operation of our algorithm on that topology. The algorithm is particularly well suited to multicast networks and optical networks, where trees may be created by signal splitting.
Synthetic Studies of Imidazole C-Nucleoside Derivatives: Their Application to Histamine H3- and H4-Ligands (2003)

Synthetic studies of imidazole C-nucleoside derivatives and their application to novel histamine H3- and H4-ligands are described, in which the following items are covered. 1) Stereoselective synthesis of imidazole C-nucleosides via diazafulvene intermediates. 2) Synthesis of tetrahydrofuranylimidazoles using efficient use of a PhSe group and its application to novel histamine H3-ligands. 3) Histamine H3- and H4-agonistic activities of imifuramine derivatives. 4) Efficient synthesis of imifuramine and its stereoisomer via diazafulvene intermediates. 5) Difference between diazafulvene cyclization and intramolecular Mitsunobu reaction of 1, 4-diols.
Automatically Extracting Web API Specifications from HTML Documentation (2018)

Web API specifications are machine-readable descriptions of APIs. These specifications, in combination with related tooling, simplify and support the consumption of APIs. However, despite the increased distribution of web APIs, specifications are rare and their creation and maintenance heavily relies on manual efforts by third parties. In this paper, we propose an automatic approach and an associated tool called D2Spec for extracting specifications from web API documentation pages. Given a seed online documentation page on an API, D2Spec first crawls all documentation pages on the API, and then uses a set of machine learning techniques to extract the base URL, path templates, and HTTP methods, which collectively describe the endpoints of an API. We evaluated whether D2Spec can accurately extract endpoints from documentation on 120 web APIs. The results showed that D2Spec achieved a precision of 87.5% in identifying base URLs, a precision of 81.3% and a recall of 80.6% in generating path templates, and a precision of 84.4% and a recall of 76.2% in extracting HTTP methods. In addition, we found that D2Spec was useful when applied to APIs with pre-existing API specifications: D2Spec revealed many inconsistencies between web API documentation and their corresponding publicly available specifications. Thus, D2Spec can be used by web API providers to keep documentation and specifications in synchronization.
Separation of complex signals with known source distributions in time-varying channels using optimum complex block adaptive ICA (2007)

This paper presents a novel realization of the complex block adaptive independent component analysis algorithm. The algorithm optimally updates the real and imaginary components of the weight vector independently. The new implementation is employed for the separation of complex signals with known source distributions, a scenario frequently encountered in practice. Under time-varying channel conditions, the performance of the proposed method is compared with the widely known Complex Fast-ICA. Simulation results show that this new technique exhibits superior performance in time varying channel conditions in terms of convergence speed. In addition, the performance of the proposed method is independent of the processing block length and is achieved without any additional cost in computational complexity.
Bio-miR: A prognostic microRNA-based signature for localized clear cell renal cell carcinoma. (2022)

e16519 Background: Prognosis of localized clear cell renal cell carcinoma (ccRCC) patients is estimated by nomograms based on clinico-pathological factors. However, clinical guidelines do not recommend their use. Recently, pembrolizumab has demonstrated benefit in disease-free survival (DFS) in medium-high risk localized ccRCC, increasing the need for better patient stratification tools. In this study, we have defined and validated a molecular signature, Bio-miR, based on the expression of nine microRNAs, with prognostic value in ccRCC. Methods: The discovery and two validation cohorts (Leeds-UK and Spain) consisted of patients with resected localized (stage Ib-III) ccRCC and no adjuvant therapy. miRNA expression was analyzed using microarrays and validated using qPCR in FFPE nephrectomy tissues. Cox regression was used to define the best microRNAs combination to predict risk of relapse. Results: In the discovery cohort (n = 71), DFS at 5 years was 93.9% amongst Bio-miR-defined low-risk patients and 61.6% in high-risk patients (HR = 6.9 (3.4-42.9), p < 0.001). Cancer-specific survival at 5 years was 95.7% and 86.4% in low- and high-risk patients, respectively (HR = 7.7 (1.7-35.1), p < 0.01). Bio-miR compared favorably with different histopathological factors and UISS and Karakiewicz´s nomograms. In the Leeds validation cohort (n = 75/95 passing qPCR quality control), patients defined as low-risk had a 5-year DFS rate of 94% versus 62% in high-risk defined disease. In this cohort Bio-miR was able to divide the Leibovich intermediate-risk population into two groups with divergent five-year DFS rates (100% vs 71%). In the Spanish validation cohort (n = 180), DFS rates at 5 years were 82.9% in the low-risk group and 58.7% in the high-risk group (HR = 2.4 (1.4-4.4); p < 0.005). Applying the inclusion criteria from the phase III KEYNOTE-564 trial, Bio-miR identifies a small low-risk population who could be spared adjuvant treatment. Conversely, amongst patients excluded from the study due to low-risk features, Bio-miR defines a high-risk population (DFS at five years of 50%) who should be prioritized for adjuvant therapy. Conclusions: We define and validate a nine-microRNA based signature capable of dichotomizing patients with localized ccRCC into low- and high-risk groups based on risk of relapse. Importantly, Bio-miR acts independently of tumor stage and grade and could, therefore, help refine the selection of patients for adjuvant therapy as well as inform the design of future adjuvant ccRCC trials.
Plasma Derived from Human Umbilical Cord Blood Modulates Mitogen-Induced Proliferation of Mononuclear Cells Isolated from the Peripheral Blood of ALS Patients (2016)

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by degeneration of motor neurons in the spinal cord and brain. This disease clinically manifests as gradual muscular weakness and atrophy leading to paralysis and death by respiratory failure. While multiple interdependent factors may contribute to the pathogenesis of ALS, increasing evidence shows the possible presence of autoimmune mechanisms that promote disease progression. The potential use of plasma derived from human umbilical cord blood (hUCB) as a therapeutic tool is currently in its infancy. The hUCB plasma is rich in cytokines and growth factors that are required for growth and survival of cells during hematopoiesis. In this study, we investigated the effects of hUCB plasma on the mitogen-induced proliferation of mononuclear cells (MNCs) isolated from the peripheral blood of ALS patients and apoptotic activity by detection of caspase 3/7 expression of the isolated MNCs in vitro. Three distinct responses to phytohemagglutinin (PHA)-induced proliferation of MNCs were observed, which were independent of age, disease duration, and the ALS rating scale: Group I responded normally to PHA, Group II showed no response to PHA, while Group III showed a hyperactive response to PHA. hUCB plasma attenuated the hyperactive response (Group III) and potentiated the normal response in Group I ALS patients, but did not alter that of the nonresponders to PHA (Group II). The elevated activity of caspase 3/7 observed in the MNCs from ALS patients was significantly reduced by hUCB plasma treatment. Thus, study results showing different cell responses to mitogen suggest alteration in lymphocyte functionality in ALS patients that may be a sign of immune deficiency in the nonresponders and autoimmunity alterations in the hyperactive responders. The ability of hUCB plasma to modulate the mitogen cell response and reduce caspase activity suggests that the use of hUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients.
Generalized Lempel–Ziv Compression for Audio (2007)

We introduce a novel compression paradigm to generalize a class of Lempel-Ziv algorithms for lossy compression of multimedia. Based upon the fact that music, in particular electronically generated sound, has substantial level of repetitiveness within a single clip, we generalize the basic Lempel-Ziv compression algorithm to support representing a single window of audio using a linear combination of filtered past windows. In this positioning paper, we present a detailed overview of the new lossy compression paradigm, we identify the basic challenges such as similarity search and present preliminary experimental results on a benchmark of electronically generated musical pieces
Recent Advances in Intra Prediction for the Emerging H.266/VVC Video Coding Standard (2019)

Design of the emerging Versatile Video Coding standard has two primary goals: to specify a video coding technology with a substantially higher compression capability, and to make it highly versatile, i.e. to make it effective for a broadened range of applications. This paper gives an overview of the core of video coding standard, namely intra prediction tools that were developed recently. Most of the developments has been studied previously during the first exploration phase started in October 2015 and eventually adopted to the VVC standard draft during the second phase that had begun in April 2018.