gebhart/patrepeval huggingface dataset:
High Electric Resistance Polymer/Lipid Composite Films on Indium−Tin−Oxide Electrodes (1999)

We report the design of polymer/lipid composite films on polarizable indium−tin−oxide (ITO) electrodes and the characterization of their electrical properties by impedance spectroscopy. The polymer films separating the solid surfaces and the lipid membranes were composed of “hairy-rod” macromolecules and provided a fluid and homogeneous ultrathin “cushion” for the deposition of lipid membranes. Two types of polymer cushions were designed: First, electrically insulating multilayers of cellulose derivatives with substituted alkyl chains forming a fluid hydrophobic “brush” at the surface. Second, conducting cellulose multilayers exposing hydrophilic surfaces for the deposition of self-healing lipid bilayers. The electrical properties, the defect densities, and the homogeneities of the stratified films were studied by impedance spectroscopy in the frequency range between 90 mHz and 50 kHz. Impedance spectra were analyzed in terms of equivalent circuits with resistances, capacitances, and so-called “constant phase elements”. Resistances of up to 440 kΩ cm2 were achieved for the polymer-supported lipid bilayers, which corresponds to about 10% of the value for black lipid membranes containing hexane. The gramicidin channels reconstituted into the supported lipid bilayers exhibited the expected cation selectivity.
<i>Zfp206</i> Is a Transcription Factor That Controls Pluripotency of Embryonic Stem Cells (2007)

Zfp206 (ZNF206 in human) encodes a zinc finger- and SCAN domain-containing protein that is highly expressed in pluripotent ESC. Upon differentiation of human and mouse ESC, Zfp206 expression is quickly repressed. Zfp206 was found to be expressed throughout embryogenesis but absent in adult tissues except testis. We have identified a role for Zfp206 in controlling ESC differentiation. ESC engineered to overexpress Zfp206 were found to be resistant to differentiation induced by retinoic acid. In addition, ESC with knocked-down expression of Zfp206 were more sensitive to differentiation by retinoic acid treatment. We found that Zfp206 was able to enhance expression from its own promoter and also activate transcription of the Oct4 and Nanog promoters. Our results show that Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells.
Thymosin α1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance (2006)

Thymosin alpha1 (Talpha1), a naturally occurring thymic peptide, primes dendritic cells (DCs) for antifungal T-helper type 1 resistance through Toll-like receptor 9 (TLR9) signaling. As TLR9 signaling also activates the immuno-suppressive pathway of tryptophan catabolism via indoleamine 2,3-dioxygenase (IDO), we examined Talpha1 for possible induction of DC-dependent regulatory effects. Talpha1 affected T-helper cell priming and tolerance induction by human and murine DCs and induced IDO expression and function in the latter cells. IDO activation by Talpha1 required TLR9 and type I interferon receptor signaling and resulted in interleukin-10 production and generation of regulatory T cells. In transfer experiments, functionally distinct subsets of differentiated DCs were required for priming and tolerance to a fungal pathogen or alloantigens. In contrast, Talpha1-primed DCs fulfilled multiple requirements, including the induction of T-helper type 1 immunity within a regulatory environment. Thus, instructive immunotherapy with Talpha1 targeting IDO-competent DCs could allow for a balanced control of inflammation and tolerance.
Syntheses of Raspberrylike Silica/Polystyrene Materials (2002)

Raspberrylike hybrid organic−inorganic materials consisting of spherical silica beads supporting smaller polystyrene particles were prepared through a heterophase polymerization process. In a first step, micrometer-sized silica particles were synthesized according to procedures inspired from the literature. In a second step, a poly(ethylene glycol) macromonomer was adsorbed on the surface of the silica beads. Finally, polymerization of styrene was achieved in water with a nonionic surfactant as an emulsifying agent and sodium persulfate as an initiator. Scanning and transmission electron microscopies show that the presence of the macromonomer on the surface of the silica particles is a determining parameter in order to get the raspberrylike morphology.
Fabrication of polyvinyl chloride based nanocomposite nanofiltration membrane: investigation of SDS/Al<sub>2</sub>O<sub>3</sub> nanoparticle concentration and solvent ratio effects (2015)

Abstract In the current research polyvinylchloride‐based nanocomposite nanofiltration membranes were prepared by using of sodium dodecyl sulfate (SDS) as additive, aluminum oxide (Al 2 O 3 ) nanoparticles as inorganic filler and dimethylacetamide (DMAC)/tetrahydrofuran (THF) as solvents via phase inversion method. The effect of solvents ratio (DMAC to THF), SDS concentration and Al 2 O 3 nanoparticle concentration in the casting solution on membrane physico‐chemical properties was studied. The flux, selectivity and water content measurements and also scanning electron microscope analysis were carried out for the membrane characterization. The increase of THF concentration in the casting solution led to decrease of membrane flux and increase of salt rejection. Additionally, flux was reduced, and rejection was enhanced by utilizing of SDS in the casting solution significantly. Furthermore, membrane flux was improved initially and then declined by increase of Al 2 O 3 nanoparticle content ratio in membrane matrix. This was followed by nearly constant trend of rejection by increase of nanoparticle concentration. The optimum concentrations of used SDS and Al 2 O 3 nanoparticles and solvent (DMAC:THF) ratio were found 0.45 %wt, 0.05 %wt and (85:15) ( V/V ) respectively. © 2015 Curtin University of Technology and John Wiley & Sons, Ltd.
Skeletal growth of the deep‐sea hexactinellid sponge <i>Euplectella oweni</i>, and host selection by the symbiotic shrimp <i>Spongicola japonica</i> (Crustacea: Decapoda: Spongicolidae) (2002)

Abstract Aspects of the skeletal growth of the deep‐sea hexactinellid sponge Euplectella oweni Herklots and Marshall, and host size and type selection by the symbiotic shrimp Spongicola japonica Kubo were investigated using field‐collected material. Two phases, flexible and stiff, were observed in the framework of the sponges. In the flexible sponges, the circular, longitudinal and oblique systems of the skeletal beams that constitute the principal framework were not fused to each other, and the parietal ledges running circularly, or sometimes obliquely, on the wall were not developed. The skeletal wall was fragile in texture, readily torn by any external force. The wall was much sturdier in the stiff sponges, in which the systems of the skeletal beams were coarse, fused to each other to make the principal framework tough in texture, and pareital ledges developed so as to reinforce the sponge wall. The flexible phase is mainly seen in smaller and younger sponges, while the stiff phase was seen in the larger (or dead) ones. Almost all the solitary and young pairs of shrimps were collected from flexible sponges.
Cross-links in Carbon Nanotube Assembly Introduced by Using Polyacrylonitrile as Precursor (2013)

Individual carbon nanotube (CNT) exhibits extraordinary mechanics. However, the properties of the macroscopic CNT-based structure, such as CNT fibers and films, are far lower than that of individual CNT. One of the main reasons is the weak interaction between tubes and bundles in the CNT assemblies. It is understood that the cross-links in CNT assembly play a key role to improve the performance of CNT-based structure. Different approaches have been taken to create CNT joints. Most of these approaches focus on connecting CNTs by generating new covalent bonding between tubes. In this work, we intend to reinforce the CNT network by locking the contacted CNTs. Polyacrylonitrile (PAN) was used as precursor because PAN can form graphitic structures after carbonization. The freestanding superthin CNT sheet and CNT yarn were used to evaluate the effects of the PAN precursor to form cross-links between CNTs. The tensile strength of CNT yarn is improved when the yarn is partially infiltrated with PAN and consequently carbonated. High-resolution transmission electron microscopy observation of the sheets shows that graphite structures are formed and cross-link CNTs in CNT assembly.
ClepsydraCache -- Preventing Cache Attacks with Time-Based Evictions (2021)

In the recent past, we have witnessed the shift towards attacks on the microarchitectural CPU level. In particular, cache side-channels play a predominant role as they allow an attacker to exfiltrate secret information by exploiting the CPU microarchitecture. These subtle attacks exploit the architectural visibility of conflicting cache addresses. In this paper, we present ClepsydraCache, which mitigates state-of-the-art cache attacks using a novel combination of cache decay and index randomization. Each cache entry is linked with a Time-To-Live (TTL) value. We propose a new dynamic scheduling mechanism of the TTL which plays a fundamental role in preventing those attacks while maintaining performance. ClepsydraCache efficiently protects against the latest cache attacks such as Prime+(Prune+)Probe. We present a full prototype in gem5 and lay out a proof-of-concept hardware design of the TTL mechanism, which demonstrates the feasibility of deploying ClepsydraCache in real-world systems.
Screening and confirmatory determination of ractopamine residues in calves treated with growth promoting doses of the β-agonist (1998)

Ractopamine (RCT) is a phenethanolamine member of the family of beta-adrenergic agonists (beta-agonists). This class of compounds have become notable for their properties of enhancing the growth rates of farm animal species but are not licensed for use in Europe. An ELISA procedure employing a polyclonal antibody raised in a goat was developed to detect RCT residues in bovine urine samples. The assay had a high sensitivity (calibration curve mid-point of 22 pg per well), allowing the analysis of urine samples without the need for sample clean-up. In addition, an LC-MS-MS confirmatory procedure was developed which was able to act as a confirmatory procedure for the ELSA results. Four calves were orally treated with RCT (0.1 mg kg-1 body mass for 17 d) and urine samples collected were assayed by both analytical procedures. It was observed that RCT residues were excreted mainly in the form of glucuronides and deconjugation could be achieved using two different sources of the enzyme beta-glucuronidase (Helix pomatia and Escherichia coli). High concentrations of RCT residues were found throughout the medication period (44-473 ng ml-1; LC-MS-MS data) and remained present for several days following removal of the drug from the diet. RCT residues were no longer detectable 2 weeks after withdrawal. Good agreement (r2 = 0.73) was achieved between the ELISA and LC-MS-MS results, especially when sample deconjugation was applied to the urine samples for sets of analyses. The results show that an effective screening and confirmatory system was devised to detect RCT residues in urine samples taken during treatment and close to withdrawal. However, alternative matrices may have to be selected to allow the illegal use of the substance to be detected following prolonged withdrawal times.
Regularized subspace Gaussian mixture models for cross-lingual speech recognition (2011)

We investigate cross-lingual acoustic modelling for low resource languages using the subspace Gaussian mixture model (SGMM). We assume the presence of acoustic models trained on multiple source languages, and use the global subspace parameters from those models for improved modelling in a target language with limited amounts of transcribed speech. Experiments on the GlobalPhone corpus using Spanish, Portuguese, and Swedish as source languages and German as target language (with 1 hour and 5 hours of transcribed audio) show that multilingually trained SGMM shared parameters result in lower word error rates (WERs) than using those from a single source language. We also show that regularizing the estimation of the SGMM state vectors by penalizing their ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -norm help to overcome numerical instabilities and lead to lower WER.
Real time DSP based implementation of a new control method of active power filter (2002)

This paper deals with a DSP based implementation of a new control method of a 3-phase active filter (AF) to compensate harmonics and reactive power of nonlinear loads. A current controlled voltage source inverter (CC-VSI) based configuration is used as the AF and PWM current control technique is used to derive gating signals to the devices of the AF. A 3-phase diode bridge rectifier with resistive-inductive loading is taken as the nonlinear load. Steady state as well as transient test results on a developed prototype are given to validate the new control method for the AF.
Pattern of diversity in the genomic region near the maize domestication gene <i>tb1</i> (2003)

Domesticated maize and its wild ancestor (teosinte) differ strikingly in morphology and afford an opportunity to examine the connection between strong selection and diversity in a major crop species. The tb1 gene largely controls the increase in apical dominance in maize relative to teosinte, and a region of the tb1 locus 5′ to the transcript sequence was a target of selection during maize domestication. To better characterize the impact of selection at a major “domestication” locus, we have sequenced the upstream tb1 genomic region and systematically sampled nucleotide diversity for sites located as far as 163 kb upstream to tb1 . Our analyses define a selective sweep of ≈60–90 kb 5′ to the tb1 transcribed sequence. The selected region harbors a mixture of unique sequences and large repetitive elements, but it contains no predicted genes. Diversity at the nearest 5′ gene to tb1 is typical of that for neutral maize loci, indicating that selection at tb1 has had a minimal impact on the surrounding chromosomal region. Our data also show low intergenic linkage disequilibrium in the region and suggest that selection has had a minor role in shaping the pattern of linkage disequilibrium that is observed. Finally, our data raise the possibility that maize-like tb1 haplotypes are present in extant teosinte populations, and our findings also suggest a model of tb1 gene regulation that differs from traditional views of how plant gene expression is controlled.
Cell Junctions of the Glomerular Epithelium in a Very Early Vertebrate (Myxine glutinosa) (2015)

The glomerular epithelial cells of the Atlantic hagfish (Myxine glutinosa) lack a slit diaphragm which is replaced by filaments. The epithelial cells show numerous occluding junctions (maculae and fasciae occludentes), septate desmosome-like junctions and desmosomes. The present findings are compared with available data on developing and mature glomerular epithelial cells of mammals.
Achievement of a 10 kV IMD system by 6 kV three-level NPC inverter with IGCTs in series connection applied in water works (2004)

A high power 10 kV IMD (induction motor drives) system supplied by a 6 kV three-level NPC (neutral point clamped) inverter with IGCTs (integrated gate commutated thyristors) in series connection, which applied in water works has been developed and achieved. The designed three-level inverter system includes a 24 pulses rectifier, a diode NPC three-level medium voltage VSI (voltage source inverter). The three-level inverter operates with 2 IGCTs in series connection in each cell with an output LC filter in order to obtain a 6 kV high voltage output. Because of the high power IMDS has 10 kV line voltage input, which must be changed from a star connection to a delta connection to fit the 6 kV output inverter. According to the PUMP load, a DSP (data signal processor) with FPGA (field programming gate array) controller is adopted to fulfill an optimized constant V/Hz control strategy. The PWM-SHE (pulse width modulation-special harmonic elimination) pattern is presented to keep the inverter has sinusoidal output with minimal harmonics and minimal torque ripple. Achievement and control strategy of the designed system have been presented and discussed.
Multiple Reaction Monitoring Assay for Pre-eclampsia Related Calcyclin Peptides in Formalin Fixed Paraffin Embedded Placenta (2011)

Although the cause of pre-eclampsia during pregnancy has not been elucidated yet, it is evident that placental and maternal endothelial dysfunction is involved. We previously demonstrated that in early onset pre-eclampsia placental calcyclin (S100A6) expression is significantly higher compared to controls ( De Groot , C. J. ; Clin. Proteomics 2007 , 1 , 325 ). In the current study, the results were confirmed and relatively quantified by using multiple reaction monitoring (MRM) on two peptide fragments of calcyclin. Cells were obtained from control (n = 5) and pre-eclamptic placental (n = 5) tissue collected by laser capture microdissection from formalin-fixed paraffin-embedded (FFPE) material treated with a solution to reverse formalin fixation. Two calcyclin peptides with an extra glycine inserted in the middle of the amino acid sequence were synthesized and used as an internal reference. Data presented show that MRM on laser microdissected material from FFPE tissue material is possible. The developed MRM assay to study quantitative levels of proteins in FFPE laser microdissected cells using nonisotopic-labeled chemical analogs of mass tagged internal references showed that in pre-eclamptic patients elevated levels of calcyclin is observed in placental trophoblast cells compared to normal trophoblast cells. By immunohistochemistry, we were able to confirm this observation in a qualitative manner.
Comparison of the eSwab collection and transportation system to an amies gel transystem for Gram stain of clinical specimens (2009)

Microscopic examination performed using ESwab, especially when preparing the slides with 100 mul, shows superior results to those obtained using the Amies gel Transystem.
Digitally controlled distributed multiphase DC-DC converters (2009)

This paper describes a distributed master-slave multiphase DC-DC converter architecture and related digital control and communication techniques. In the distributed master-slave architecture, all converter modules are identical, but one module operates as the master. The master module communicates its voltage error and current data over a single-wire serial bus to remove the voltage sensing mismatch and to accomplish active current sharing among the modules. Experimental results are shown for a 5 V-to-12 V input, 1.3 V, 20 A output two-phase synchronous buck converter.
Generating code for holistic query evaluation (2010)

We present the application of customized code generation to database query evaluation. The idea is to use a collection of highly efficient code templates and dynamically instantiate them to create query- and hardware-specific source code. The source code is compiled and dynamically linked to the database server for processing. Code generation diminishes the bloat of higher-level programming abstractions necessary for implementing generic, interpreted, SQL query engines. At the same time, the generated code is customized for the hardware it will run on. We term this approach holistic query evaluation. We present the design and development of a prototype system called HIQUE, the Holistic Integrated Query Engine, which incorporates our proposals. We undertake a detailed experimental study of the system's performance. The results show that HIQUE satisfies its design objectives, while its efficiency surpasses that of both well-established and currently-emerging query processing techniques.
Quantum size effect in an Fe quantum well detected by resonant tunneling carriers injected from a <i>p</i>-type Ge semiconductor electrode (2018)

We report the clear observation of the quantum size effect in an Fe quantum well (QW) detected by resonant tunneling carriers injected from a p-type Ge semiconductor electrode in fully epitaxial double-barrier magnetic tunnel junctions, which are composed of Co/Fe/MgO/Fe QW/MgO/Ge:B grown on a p+-Ge(001) substrate. A large tunnel magnetoresistance (TMR) ratio up to 137% (237%), which is comparable to that in Fe/MgO/Fe, is obtained at 297 K (3.5 K). The quantum oscillations are clearly observed in the dI/dV–V and d2I/dV2–V curves of our devices, and the resonance voltages are in good agreement with the resonant levels calculated by the phase accumulation model. Following these oscillations, the TMR is modulated by the quantum size effect. Our results are promising for realizing future quantum spintronics devices based on semiconductor/metal hybrid heterostructures with advanced functionalities.
Cylindrical waves in transversely isotropic media (1981)

Because of fine layering, many sedimentary rocks can be characterized as transversely isotropic, possessing an axis of symmetry perpendicular to the layering. The many kinds of measurements made in fluid-filled holes drilled parallel to this axis prompted this study of axisymmetric cylindrical waves. The literature shows how such waves in an isotropic solid can be expressed in terms of a compressional potential or a shear potential. This paper shows that in a transversely isotropic medium, particular combinations of these potentials are needed simultaneously, yielding either a quasi-compressional wave or a quasi-shear wave. The expressions are used to compute the transient response of an acoustic logging tool. The speeds of refracted compressional and shear waves agree with the speeds of plane waves traveling along the axis of symmetry. Dispersive waves in the fluid annulus yield further information about the elastic constants of the solid. The potentials also portray the radiation of elastic waves from a point force or from a transducer on the surface.
Long‐term effects of mandibular repositioning appliances on symptoms of sleep apnoea (2007)

Mandibular repositioning appliances (MRAs) reduce symptoms of obstructive sleep apnoea in the short term, but the long-term effects are unknown. Our objective was to evaluate the long-term symptomatic effects of custom-made MRAs and to identify the patients who will experience subjective benefits from treatment. A cohort of 260 consecutive patients treated with appliances for non-apnoeic snoring or sleep apnoea was followed up by a questionnaire and examination after an average of 5.4 years. The subjective effect was defined as good when complaints of daytime sleepiness occurred less than once a week. A total of 185 patients (71%) responded to the questionnaires. Of the respondents, 96 reported frequent use, 33 reported infrequent use, 26 reported discontinued treatment and 30 reported modified treatment. Mild cases (apnoea-hypopnoea index [AHI] < 15) were likelier than more severe cases to continue treatment. Patients who had used MRAs reported fewer complaints of sleepiness, headaches and daytime naps. Frequent use (P = 0.001), few night-time awakenings before start of treatment (P = 0.02) and effective apnoea reduction during treatment of more severe cases (P = 0.02) correlated with a good subjective effect at long-term follow-up. Our conclusion is that custom-made MRAs reduce sleep apnoea symptoms in the long term. The mildest cases will experience the greatest long-term benefit. The reason is that non-apnoeic snorers and patients with a mild disease are more likely to continue treatment and that their long-term results with regard to excessive sleepiness are similar to patients with a more severe disease.