gebhart/patrepeval huggingface dataset:
Learning to Rank for Synthesizing Planning Heuristics (2016)

We investigate learning heuristics for domain-specific planning. Prior work framed learning a heuristic as an ordinary regression problem. However, in a greedy best-first search, the ordering of states induced by a heuristic is more indicative of the resulting planner's performance than mean squared error. Thus, we instead frame learning a heuristic as a learning to rank problem which we solve using a RankSVM formulation. Additionally, we introduce new methods for computing features that capture temporal interactions in an approximate plan. Our experiments on recent International Planning Competition problems show that the RankSVM learned heuristics outperform both the original heuristics and heuristics learned through ordinary regression.
The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures (2010)

Although dopamine D(3) receptor antagonists have been shown to enhance frontocortical cholinergic transmission and improve cognitive performance in rodents, data are limited and their effects have never been examined in primates. Accordingly, we characterized the actions of the D(3) receptor antagonist, S33138, in rats and rhesus monkeys using a suite of procedures in which cognitive performance was disrupted by several contrasting manipulations. S33138 dose-dependently (0.01-0.63 mg/kg s.c.) blocked a delay-induced impairment of novel object recognition in rats, a model of visual learning and memory. Further, S33138 (0.16-2.5 mg/kg s.c.) similarly reduced a delay-induced deficit in social novelty discrimination in rats, a procedure principally based on olfactory cues. Adult rhesus monkeys were trained to perform cognitive procedures, then chronically exposed to low doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine which produced cognitive impairment without motor disruption. In an attentional set-shifting task of cognitive flexibility involving an extra-dimensional shift, deficits were reversed by S33138 (0.04 and 0.16 mg/kg p.o.). S33138 also significantly improved accuracy (0.04 and 0.16 mg/kg p.o.) at short (but not long) delays in a variable delayed-response task of attention and working memory. Finally, in a separate set of experiments performed in monkeys displaying age-related deficits, S33138 significantly (0.16 and 0.63 mg/kg p.o.) improved task accuracies for long delay intervals in a delayed matching-to-sample task of working memory. In conclusion, S33138 improved performance in several rat and primate procedures of cognitive impairment. These data underpin interest in D(3) receptor blockade as a strategy for improving cognitive performance in CNS disorders like schizophrenia and Parkinson's disease.
Simultaneous production of interleukin 2, interleukin 4 and interferon‐γ by activated human blood lymphocytes (1990)

The production of interleukin 2 (IL 2), IL 4 and interferon-gamma (IFN-gamma) by in vitro activated unselected human blood mononuclear cells was studied at a single-cell level. Individual lymphokine-synthesizing cells were identified by intracellular immunofluorescent staining using cytokine-specific monoclonal or polyclonal antibodies. Cultures from adult blood donors revealed a biphasic kinetic production pattern for IL 2 and IFN-gamma with peaks occurring 4-6 and 24-30 h after initiation of the cultures. Approximately 20%-40% of the lymphocytes produced IL 2 and IFN-gamma. In contrast, only 1%-3% of the lymphocytes synthesized IL 4 with maximal frequency after 6 h of culture. CD4+ as well as CD8+ T cells contributed to the synthesis of all three lymphokines studied. CD4+CD45R- T cells were the major producers of IL 2 and IL 4, while CD8+CD45R- T cells were the most common phenotype of IFN-gamma-synthesizing cells. By performing two-color immunofluorescence studies we observed that among IL 4-producing cells every second one made simultaneously IL 2 and every fourth one made IFN-gamma. Mononuclear cells from umbilical cord blood could be stimulated to make IL 2 to the same extent as cells from adult blood donors. No IL 4 production and a strikingly reduced frequency of IFN-gamma producers were noted in cell cultures from neonates. IL 2, IL 4 and IFN-gamma accumulated in the Golgi system, which resulted in a characteristic morphology of the staining, eliminating problems with evaluation of background signals.
Integrating the ECG power-line interference removal methods with rule-based system. (1995)

The power-line frequency interference in electrocardiographic signals is eliminated to enhance the signal characteristics for diagnosis. The power-line frequency normally varies +/- 1.5 Hz from its standard value of 50 Hz. In the present work, the performances of the linear FIR filter, Wave digital filter (WDF) and adaptive filter for the power-line frequency variations from 48.5 to 51.5 Hz in steps of 0.5 Hz are studied. The advantage of the LMS adaptive filter in the removal of power-line frequency interference even if the frequency of interference varies by +/- 1.5 Hz from its normal value of 50 Hz over other fixed frequency filters is very well justified. A novel method of integrating rule-based system approach with linear FIR filter and also with Wave digital filter are proposed. The performances of Rule-based FIR filter and Rule-based Wave digital filter are compared with the LMS adaptive filter.
Neuronal Cell Death in Alzheimers Disease and a Neuroprotective Factor, Humanin (2006)

Brain atrophy caused by neuronal loss is a prominent pathological feature of Alzheimer's disease (AD). Amyloid beta (Abeta), the major component of senile plaques, is considered to play a central role in neuronal cell death. In addition to removal of the toxic Abeta, direct suppression of neuronal loss is an essential part of AD treatment; however, no such neuroprotective therapies have been developed. Excess amount of Abeta evokes multiple cytotoxic mechanisms, involving increase of the intracellular Ca(2+) level, oxidative stress, and receptor-mediated activation of cell-death cascades. Such diversity in cytotoxic mechanisms induced by Abeta clearly indicates a complex nature of the AD-related neuronal cell death. We have identified a 24-residue peptide, Humanin (HN), which suppresses in vitro neuronal cell death caused by all AD-related insults, including Abeta, so far tested. The anti-AD effect of HN has been further confirmed in vivo using mice with Abeta-induced amnesia. Altogether, such potent neuroprotective activity of HN against AD-relevant cytotoxicity both in vitro and in vivo suggests the potential clinical applications of HN in novel AD therapies aimed at controlling neuronal death.
A touch interface for soft data modeling in Bayesian estimation (2014)

A novel approach for human-generated “soft information” modeling and Bayesian fusion using touch interface devices is presented. The human-generated soft information can be encoded using a combination of single, multiple, and overlapping strokes that represent arbitrary measurement likelihood functions which can be approximated using non-parametric density estimators. The proposed interface offers a flexible and natural medium to encode a large class of qualitatively distinct types of information for both positive and negative observations. The touch interface naturally provides robustness with respect to human variability in terms of psycho-physiological and environmental parameters without the need for offline training. An urban-target tracking example is provided to illustrate fusion of soft information (generated using the proposed soft sensor model) with measurements from traditional automated sensors.
100-Gb/s discrete-multitone transmission over 80-km SSMF using single-sideband modulation with novel interference-cancellation scheme (2015)

We present a novel scheme to cancel signal-signal beat interference in direct-detection systems with single-sideband modulation. We use this scheme to successfully transmit 80-Gb/s SSB-DMT at 1550 nm over 80-km SSMF with margin.
Identification of genes required for Pseudomonas aeruginosa carnitine catabolism (2009)

Carnitine is a quaternary amine compound prevalent in animal tissues, and a potential carbon, nitrogen and energy source for pathogens during infection. Characterization of activities in Pseudomonas aeruginosa cell lysates has previously shown that carnitine is converted to 3-dehydrocarnitine (3-dhc) which is in turn metabolized to glycine betaine (GB), an intermediate metabolite in the catabolism of carnitine to glycine. However, the identities of the enzymes required for carnitine catabolism were not known. We used a genetic screen of the P. aeruginosa PA14 transposon mutant library to identify genes required for growth on carnitine. We identified two genomic regions and their adjacent transcriptional regulators that are required for carnitine catabolism. The PA5388-PA5384 region contains the predicted P. aeruginosa carnitine dehydrogenase homologue along with other genes required for growth on carnitine. The second region identified, PA1999-PA2000, encodes the alpha and beta subunits of a predicted 3-ketoacid CoA-transferase, an enzymic activity hypothesized to be involved in the first step of deacetylation of 3-dhc. Furthermore, we confirmed that an intact GB catabolic pathway is required for growth on carnitine. The PA5389 and PA1998 transcription factors are required for growth on carnitine. PA5389 is required for induction of the PA5388-PA5384 transcripts in response to carnitine, and the PA1999-PA2000 transcripts are induced in a PA1998-dependent manner and induction appears to depend on a carnitine catabolite, possibly 3-dhc. These results provide important insight into elements required for carnitine catabolism in P. aeruginosa and probably in other bacteria.
Graphene as an atomically thin barrier to Cu diffusion into Si (2014)

The evolution of copper-based interconnects requires the realization of an ultrathin diffusion barrier layer between the Cu interconnect and insulating layers. The present work reports the use of atomically thin layer graphene as a diffusion barrier to Cu metallization. The diffusion barrier performance is investigated by varying the grain size and thickness of the graphene layer; single-layer graphene of average grain size 2 ± 1 μm (denoted small-grain SLG), single-layer graphene of average grain size 10 ± 2 μm (denoted large-grain SLG), and multi-layer graphene (MLG) of thickness 5-10 nm. The thermal stability of these barriers is investigated after annealing Cu/small-grain SLG/Si, Cu/large-grain SLG/Si, and Cu/MLG/Si stacks at different temperatures ranging from 500 to 900 °C. X-ray diffraction, transmission electron microscopy, and time-of-flight secondary ion mass spectroscopy analyses confirm that the small-grain SLG barrier is stable after annealing up to 700 °C and that the large-grain SLG and MLG barriers are stable after annealing at 900 °C for 30 min under a mixed Ar and H2 gas atmosphere. The time-dependent dielectric breakdown (TDDB) test is used to evaluate graphene as a Cu diffusion barrier under real device operating conditions, revealing that both large-grain SLG and MLG have excellent barrier performance, while small-grain SLG fails quickly. Notably, the large-grain SLG acts as a better diffusion barrier than the thicker MLG in the TDDB test, indicating that the grain boundary density of a graphene diffusion barrier is more important than its thickness. The near-zero-thickness SLG serves as a promising Cu diffusion barrier for advanced metallization.
Surface Replacement: The Hip Replacement of the Future? (1998)

Surface replacement is a significant development in the evolution of hip arthroplasty. Unlike conventional total hip arthroplasty, surface replacement does not require resection of the femoral head; thus, it presents a potentially effective, bone-conserving alternative to conventional replacements. Moreover, conversion to total hip replacement can be made readily, if necessary, with fewer complicating factors than with total hip revision surgery. It offers the greatest potential benefit to patients who are young and physically active. Previous surface replacement used metal-on-polyethylene devices; however, the large ball size of the femoral component contributed to high volumes of polyethylene wear. For some patients, osteolysis occurred due to tissue reaction to polyethylene debris, resulting in aseptic component loosening. Recent advances in technology have allowed metal-on-metal implants to be manufactured with great precision. Hybrid and all cementless fixation, have both shown good early results without the prevalence of loosening seen with polyethylene bearings. Metal-on-metal surface replacement has proved to be quite successful. Results from patients with metal-on-metal devices, especially those with ConservePlus™ implants, show no complications; moreover, there has been an absence of pain and a return to high functional levels, including participation in sports. Due to the large ball size, metal-on-metal devices offer high stability and low dislocation rates. Hemisurface replacement of the femoral head has also proved to be successful in patients with osteonecrosis with or without collapse of the femoral head, when the acetabulum remains relatively normal. For this type of surgery, some acetabular articular cartilage must be preserved. With high survivorship over time, it has emerged as the treatment of choice for this patient group.
Modal analysis and design of the dual-band orthomode junction (2002)

An analysis and design concept for the dual-band orthomode junction is presented. The centerpiece of the design is a waveguide six-port cross junction. Its modal analysis is verified by measurements available in the literature. After introducing appropriate symmetry planes for the orthomode junction, a principal design approach is outlined. The entire procedure is demonstrated for a K/Ka-band design example. The final design is compared to results from the commercial software package HFSS and is found to be in good agreement.
7Li ‐  NMR  of Well‐Graphitized Vapor‐Grown Carbon Fibers and Natural Graphite Negative Electrodes of Rechargeable Lithium‐Ion Batteries (1999)

Lithium intercalation of natural graphite and well‐graphitized vapor‐grown carbon fibers has been investigated by solid‐state and by cyclic voltammetry. Chemical shift of in Li‐graphite intercalation compounds (Li‐GICs) of natural graphite occurs in two regions, >40 and <10 ppm. The former shifts were assigned to GICs with the in‐plane density of and the latter shifts were assigned to those with the in‐plane density of . Phase diagram of Li‐GICs during electrochemical intercalation is discussed. In comparison to natural graphite, in the vapor‐grown carbon fibers showed higher chemical shifts. The passivating film was also examined by and structural change of the film during the first charge‐discharge cycle is indicated. Scanning electron microscopy imaging of the passivation film supports the NMR data during charge‐discharge. The swelling and shrinking of passivation is evident by scanning elecron microscope image and nuclear magnetic resonance data. The thickness of the solid electrolyte interface layer depends on the nature of salt, solvent, carbon origin, and current density. © 1999 The Electrochemical Society. All rights reserved.
Papillomavirus contains cis-acting sequences that can suppress but not regulate origins of DNA replication (1994)

Bovine papillomavirus (BPV) DNA has been reported to restrict its own replication and that of the lytic simian virus 40 (SV40) origin to one initiation event per molecule per S phase, which suggests BPV DNA replication as a model for cellular chromosome replication. Suppression of the SV40 origin required two cis-acting BPV sequences (NCOR-1 and -2) and one trans-acting BPV protein. The results presented in this paper confirm the presence of two NCOR sequences in the BPV genome that can suppress polyomavirus (PyV) as well as SV40 origin-dependent DNA replication as much as 40-fold. However, in contrast to results of previous studies on SV40, most of the suppression of the PyV origin was due to NCOR-1, a 512-bp sequence that functioned independently of distance or orientation with respect to the PyV origin and that was not required for BPV DNA replication. Moreover, NCOR-1 alone or together with NCOR-2 did not restrict the ability of the PyV ori to reinitiate replication within a single S phase and did not require any BPV protein to exert suppression. Furthermore, NCOR-1 did not suppress BPV origin-dependent DNA replication except in the presence of PyV large tumor antigen (T-ag). Since NCOR-1 suppression of PyV origin activity also varied with T-ag concentration, suppression of origins by NCOR sequences appeared to require papovavirus T-ag. Therefore, it is unlikely that NCOR sequences are involved in regulating BPV DNA replication. When these results are taken together with those from other laboratories, BPV appears to be a slowly replicating version of papovaviruses rather than a model for origins of DNA replication in eukaryotic cell chromosomes.
Covariance-Preconditioned Iterative Methods for Nonnegatively Constrained Astronomical Imaging (2006)

We consider the problem of solving ill-conditioned linear systems $A\bfx=\bfb$ subject to the nonnegativity constraint $\bfx\geq\bfzero$, and in which the vector $\bfb$ is a realization of a random vector $\hat{\bfb}$, i.e., $\bfb$ is noisy. We explore what the statistical literature tells us about solving noisy linear systems; we discuss the effect that a substantial black background in the astronomical object being viewed has on the underlying mathematical and statistical models; and, finally, we present several covariance-based preconditioned iterative methods that incorporate this information. Each of the methods presented can be viewed as an implementation of a preconditioned modified residual-norm steepest descent algorithm with a specific preconditioner, and we show that, in fact, the well-known and often used Richardson-Lucy algorithm is one such method. Ill-conditioning can inhibit the ability to take advantage of a priori statistical knowledge, in which case a more traditional preconditioning approach may be appropriate. We briefly discuss this traditional approach as well. Examples from astronomical imaging are used to illustrate concepts and to test and compare algorithms.
Novel start-up circuit with enhanced power-up characteristic for bandgap references (2008)

This paper presents a new start-up circuit for low-power bandgap reference (BGR) voltage generators. The BGR is designed for providing a stable 0.3 V power supply for application in low power wireless sensor nodes. The BGR has an enhanced power-up characteristic and demonstrates a reduction of the total stand-by current. Simulated results confirm that the proposed start-up circuit does not affect the performance of the BGR even though the supply voltage (VDD) is higher and has more stable power-up characteristic than the conventional start-up circuits. The new start-up circuit is designed with 65 nm CMOS process.
Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance (2015)

Colorectal cancer (CRC) is characterized by recurrent mutations deregulating key cell signaling cascades and providing the cancer cells with novel functional traits. Among the most frequent mutations in CRC are gain-of-function missense mutations in KRAS and BRAF. Oncogenic activation of KRAS and BRAF is mutually exclusive and occurs in approximately 40% and 10% of all CRCs, respectively. Here we summarize genetic alterations currently described in the literature and databases, indicating overlapping but also specific co-occurrences with either mutated BRAF or KRAS. We describe common and potentially specific biological functions of KRAS and BRAF oncoproteins in the intestinal epithelial cells and during initiation and progression of CRC. We discuss signal transduction networks, highlighting individual functions of oncogenic KRAS and BRAF in terms of feedback loops and their impact on treatment outcome. Finally, we give an update on current strategies of targeted therapeutic intervention in oncogenic RAS-RAF signaling networks for the treatment of metastatic CRC and outline future directions.
Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system (1996)

A variety of cerebral insults induce neuronal damage to the hippocampal formation. The somatostatin-immunoreactive (SOM-ir) neurones in the dentate hilus are particularly vulnerable. In the present study, we demonstrated that augmentation of hippocampal GABAergic inhibition by chronic infusion of gamma-vinyl GABA prevented the delayed seizure-induced damage to hilar SOM-ir neurones. Selective lesions of the cholinergic, serotonergic or noradrenergic pathways to the hippocampus did not attenuate the seizure-induced loss of SOM-ir neurones; rather, the damage was exacerbated by the cholinergic lesion. It is, therefore, the intrahippocampal GABAergic circuitries, rather than the selective subcortical pathways, that are critical for neuroprotection after seizures. Enhanced GABAergic inhibition in the hippocampus prevented damage to hilar SOM-ir neurones, even when started 2 days after status epilepticus. GABAergic agents may thus provide an alternative treatment for delayed neuronal damage caused by cerebral insults.
Event-based detection of concurrency (1998)

Understanding the behavior of a system is crucial in being able to modify, maintain, and improve the system. A particularly difficult aspect of some system behaviors is concurrency. While there are many techniques to specify intended concurrent behavior, there are few, if any, techniques to capture and model actual concurrent behavior. This paper presents a technique to discover patterns of concurrent behavior from traces of system events. The technique is based on a probabilistic analysis of the event traces. Using metrics for the number, frequency, and regularity of event occurrences, a determination is made of the likely concurrent behavior being manifested by the system. The technique is useful in a wide variety of software engineering tasks, including architecture discovery, reengineering, user interaction modeling, and software process improvement.
Nanotechnology and Nanomaterials: Toxicology, Risk Assessment, and Regulations (2010)

Nanomaterials have very unique chemical and physical properties that suggest potential health hazards, but limited health and safety information exists for engineered nanomaterials. This review identifies a need for expanding efforts for addressing health and safety concerns in nanotechnology development and in nanotoxicology of engineered nanomaterials. The efforts include research to generate data for safety evaluation, toxicologic evaluation of potential human health effects, risk assessment to support risk-management decision-making, and regulations development to protect human health and the environment. The federal government's current understanding is that existing statutory authorities are adequate to address oversight of nanotechnology and its applications. On the other hand, the present review identifies weaknesses in the current research efforts and inadequacies in existing regulations. A collaborative effort involving multidisciplinary groups is a key element to address the related needs and issues. While federal agencies with regulatory responsibilities are looked upon to develop and implement sound policies and regulations to protect public health and the environment, state agencies may be required to initiate policies which rapidly incorporate new innovations and address public concerns. To address current and futures need related to nanotechnology, the responsible state agencies need to fill the information gaps and address the health and environmental issues. In California, activities have been initiated, but legislative authority and resources are required to provide risk assessment and health protection in an efficient and timely manner.