gebhart/patrepeval huggingface dataset:
Establishing the robustness of short-tandem-repeat statistics for forensic applications. (1996)

Before the introduction of a four-locus multiplex short-tandem-repeat (STR) system into casework, an extensive series of tests were carried out to determine robust procedures for assessing the evidential value of a match between crime and suspect samples. Twelve databases were analyzed from the three main ethnic groups encountered in casework in the United Kingdom: Caucasians, Afro-Caribbeans, and Asians from the Indian subcontinent. Independence tests resulted in a number of significant results, and the impact that these might have on forensic casework was investigated. It is demonstrated that previously published methods provide a simple procedure for correcting allele frequencies--and that this leads to conservative casework estimates of evidential value.
Prestin and the cochlear amplifier (2006)

In non-mammalian, hair cell-bearing sense organs amplification is associated with mechano-electric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.
3-D analysis of LiNbO<sub>3</sub>: Ti channel waveguides and directional couplers (1984)

An efficient method of calculation of effective refractive indexes and field distribution of guided optical modes in diffused channel waveguides and directional couplers is presented. Refractive index distribution which follows from the theory of two-dimensional anisotropic diffusion is considered. Experiments which relate the refractive index profile with fabrication parameters are described. Then the coupling length of a directional coupler can be calculated from the fabrication parameters. The results correspond well to recently published experimental data.
Carrier Choices of Air Passengers in Pacific Rim: Using Comparative Analysis and Complementary Interpretation of Revealed Preference and Stated Preference Data (1996)

The flight choice behavior of Korean people for long-distance international air trips that take more than 10 hr air journey time was studied. Separate logit choice models were calibrated with revealed preference (RP) data and stated preference (SP) data, and the comparative analysis and the complementary interpretation of RP and SP data were tried. Required data were collected by the survey at Kimpo International Airport in Seoul, Korea, in 1993 and 1994. Journey time, air fare, service frequency, and nationality of airline were identified as major factors influencing flight choice in the market. It is remarkable that Korean airlines were considerably preferred in the market. Most Koreans are not fluent in English or other European languages and are not accustomed to western culture. This results in their preference for Korean airlines. Value of travel time and other trade-off ratios among variables to evaluate the relative importance of each factor were also identified through the results of RP and SP data analysis.
Hot-plug based activation and deactivation of ATCA FRU devices (2009)

Abstract: One of the most important features of the Advanced Telecommunications Computing Architecture (ATCA) contributing to its exceptional reliability and availability is its hot-swap functionality. In order for the user to be able to add and remove the components of an ATCA shelf without the necessity of switching the power on and off the PCI Industrial Computer Manufacturers Group (PICMG) specification clearly enumerates the stages a Field Replaceable Unit (FRU) has to go through upon insertion into and extraction from the shelf. These stages form the activation and deactivation processes that occur every time an element is changed in the ATCA system. This paper focuses on these processes placing the emphasis on the Electronic Keying (EK) implementation in the Intelligent Platform Management Controller (IPMC) software developed for the self-designed ATCA Carrier Board for FLASH. This Carrier Board utilizes the standard-defined PCI Express (PCIe) interface as well as introduces proprietary protocols in form of Rocket IO (RIO) and Low Latency Links (LLL).
A new therapeutic strategy against cancer: cAMP elevating drugs and leptin (2009)

cAMP levels are regulated by the activity of both the enzyme adenylyl cyclase, which catalyzes its synthesis from adenosine triphosphate (ATP), and cyclic nucleotide phos-phodiesterases that catalyze its degradation. Classically, cAMP has been known to provoke its cellular response through protein kinase A (PKA) activation. PKA consists of a heterotetramer of two homodimers of the regulatory subunits (R-subunits, RIα or RIβ and RIIα or RIIβ) and two catalytic subunits (Cα, Cβ or Cγ),
Computational model for artificial learning using fonnal concept analysis (2013)

The field of artificial intelligence embraces two approaches to artificial learning. The first is motivated by the study of mental processes and states that artificial learning is the study of mechanisms embodied in the human mind. It aims to understand how these mechanisms can be translated into computer programs. The second approach initiated from a practical computing standpoint and has less grandiose aims. It involves developing programs that learn from past data, and may be considered as a branch of data processing. In this paper, we are concerned with the first approach. Artificial learning is interested in the classification learning that is a learning algorithm for categorizing unseen examples into predefined classes based on a set of training examples. We formulated a computational model for binary classification process using formal concept analysis. The classification rules are derived and applied successfully for different study cases.
MR head effects on PES generation: simulation and experiment (1996)

Two-dimensional linear, time-invariant simulation results of a magnetoresistive (MR) head readback response for Position Error Signal (PES) generation are compared with experimental data. Split-burst amplitude and null patterns are considered for the off-track study. Micro-track profiling results for use in the simulations are also presented. The simulations capture the on-track response of the MR head, although the predicted off-track response is degraded. The simulated PES predicts more non-linearity with off-track displacement than the experimental data indicates. The results suggest that more advanced simulation techniques are required for servo channel design and prediction.
Volume holographic grating-based continuously tunable optical filter (2004)

We propose and demonstrate a widely tunable optical filter, realized by angle tuning a volume holographic grating. The volume holographic grating selectively drops a narrow portion of the signal bandwidth into a fiber while passing through the rest of the signals. The demonstrated 1510- to 1590-nm tuning range covers the entire erbium-doped fiber amplifier (EDFA) C band, with small bandwidth variation and low insertion loss (<1 dB). Group delay, polarization-dependent loss, and polarization mode dispersion are measured and investigated for optimizing the filter characteristics.
Manipulation of Gastrointestinal Nutrient Delivery in Livestock (1993)

Discussed herein are the constraints of nutrient delivery from the gastrointestinal tract that are placed on postabsorptive synthetic processes in highly selected strains of domestic livestock or livestock treated with growth promotants exogenously or via transgenic manipulation. Emphasis is placed on the discussion of recent advances in the knowledge of the regulation and manipulation of digestion and the absorption by the intestinal epithelium. Slaframine, a muscarinic exocrine secretagogue with a high affinity for the gastrointestinal tract, and epidermal growth factor may have practical potential for the manipulation of digestion and absorption, respectively. Special consideration is given to energetic considerations that must accompany any manipulation of gastrointestinal function. Down-regulation and up-regulation of mechanisms must be equally considered as this area is explored further.
Acetal Linked Oligoethylenimines for Use As pH-Sensitive Gene Carriers (2008)

Two types of acid-degradable nonviral gene carriers, OEI-MK and OEI-BAA, were synthesized by polymerizing oligoethylenimine of 800 Da (OEI800) with the pH-sensitive acetone ketal cross-linker 2,2-bis(N-maleimidoethyloxy) propane (MK) or the 4-methoxybenzaldehyde bisacrylate acetal cross-linker 1,1-bis-(2-acryloyloxy ethoxy)-[4-methoxy-phenyl]methane) (BAA). Corresponding acid-insensitive counterparts (OEI-BM and LT-OEI-HD) were synthesized as well, representing control polymers. Kinetics of hydrolysis were measured and confirmed the pH-dependent degradation profile of the acetal functions, with short half-lives of 3 min at pH 5.0, and 5 h (OEI-MK) or 3.5 h (OEI-BAA) at physiological pH 7.4 and 37 degrees C. DNA polyplexes of a luciferase expression plasmid were tested for gene transfer efficiency and biocompatibility in two cell lines (B16F10 and Neuro2A). Polyplexes with acid-labile polymers showed an improved toxicity profile compared to those made with acid-stable polymer analogues. At low cation/plasmid (c/p) w/w ratios the transfection efficiency of pH-sensitive polymers was slightly reduced, but it became similar or superior to the efficiency of acid-stable polymers at higher c/p ratios. An improved in vivo biocompatibility of the acid-degradable polymers over the stable control polymers was confirmed by liver histology after systemic administration of polymers in Balb/c mice.
Nanotherapeutics for inhibition of atherogenesis and modulation of inflammation in atherosclerotic plaques (2015)

Sugar-based amphiphilic macromolecules can be complexed with α-T to establish new anti-athero-inflammatory nanotherapeutics. These dual efficacy NPs effectively inhibited key features of atherosclerosis (modified lipid uptake and the formation of foam cells) while demonstrating reduction in inflammatory markers based on a disease-mimetic model of human atherosclerotic plaques.
DNQ: Dynamic Network Quantization (2018)

Network quantization is an effective method for the deployment of neural networks on memory and energy constrained mobile devices. In this paper, we propose a Dynamic Network Quantization (DNQ) framework which is composed of two modules: a bit-width controller and a quantizer. Unlike most existing quantization methods that use a universal quantization bit-width for the whole network, we utilize policy gradient to train an agent to learn the bit-width of each layer by the bit-width controller. This controller can make a trade-off between accuracy and compression ratio. Given the quantization bit-width sequence, the quantizer adopts the quantization distance as the criterion of the weights importance during quantization. We extensively validate the proposed approach on various main-stream neural networks and obtain impressive results.
Involvement of I-J epitopes in the self- and allo-recognition sites of T cells: blocking of syngeneic and allogeneic mixed lymphocyte reaction-responder cells by monoclonal anti-I-J antibodies. (1985)

Monoclonal anti-I-Jk antibodies (mAbs) were found to inhibit syngeneic and allogeneic mixed lymphocyte reactions by blocking the responder T cells but not the stimulator cells. Only the responses of H-2k and H-2a strains were inhibited. Three different anti-I-Jk mAbs (1G8, 4B11, and KN34) showed different inhibitory patterns in allogeneic mixed lymphocyte reactions of individual H-2k strains, depending on the H-2 and immunoglobulin heavy chain variable region (IgVH) genes possessed by the stimulator strains. The results indicated that I-J epitopes are involved in the self- and allo-recognition sites of T cells, which are clonally distributed and used to recognize Ia plus IgVH-linked products.
Targeting ErbB3: the New RTK(id) on the Prostate Cancer Block (2011)

Most prostate cancers (PCa) are critically reliant on functional androgen receptor (AR) signaling. At its onset, PCa is androgen-dependent and although temporarily halted by surgically or pharmacologically blocking the AR (androgen ablation), the disease ultimately recurs as an aggressive, fatal castration resistant prostate cancer (CRPC). FDA-approved treatments like docetaxel, a chemotherapeutic agent, and Provenge, a cancer vaccine, extend survival by a scant 3 and 4 months, respectively. It is clear that more effective drugs targeting CRPC are urgently needed. The ErbB family (EGFR/ErbB1, ErbB2/HER2/neu, ErbB3/HER3 and ErbB4/HER4) of receptor tyrosine kinases (RTKs) have long been implicated in PCa initiation and progression, but inhibitors of ErbB1 and ErbB2 (prototypic family members) fared poorly in PCa clinical trials. Recent research suggests that another family member ErbB3 abets emergence of the castration-resistant phenotype. Considerable efforts are being directed towards understanding ErbB3-mediated molecular mechanisms of castration resistance and searching for novel ways of inhibiting ErbB3 activity via rational drug design. Antibody-based therapy that prevents ligand binding to ErbB3 appears promising and fully-humanized antibodies that inhibit ligand-induced phosphorylation of ErbB3 are currently in early development. Small molecule tyrosine kinase inhibitors are also being vigorously pursued, as are siRNA-based approaches and combination treatment strategies- the simultaneous suppression of ErbB3 and its signaling partners or downstream effectors - with the primary purpose of undermining the resiliency of ErbB3-mediated signal transduction. This review summarizes the existing literature and reinforces the importance of ErbB3 as a therapeutic target in the clinical management of prostate cancer.
Transcription in archaea: similarity to that in eucarya. (1995)

We present homologies between archaeal and eucaryal DNA-dependent RNA polymerase (RNAP) subunits and transcription factors. The sequences of the Sulfolobus acidocaldarius subunits D, E, and N and alignments with eucaryal homologs are presented here. The similarities between archaeal transcription factors and their eucaryal homologs TFIIB and TBP have been established in other laboratories. The archaeal RNAP subunits H, K, and N, respectively, show high sequence similarity to ABC27, ABC23, and ABC10 beta (found in all three eucaryal RNAPs); subunit D, to AC40 (common to polymerase II and polymerase III) and B44 (polymerase II); and subunit L, to AC19 and B12.5. The similarity of subunit D and its eucaryal homologs to bacterial alpha is limited to the "alpha-motif," which is also present in subunit L and its eucaryal homologs. Genes encoding homologs of the related eucaryal RNAP subunits A12.2/B12.6 and also homologs of eucaryal transcription elongation factors of the TFIIS family have been detected in Sulfolobus acidocaldarius and Thermococcus celer. In archaea, the protein is not an RNAP subunit. Together with the sequence similarities between archaeal box A-containing and eucaryal TATA box-containing promoters, this shows that the archaeal and eucaryal transcription systems are truly homologous and that they differ structurally and functionally from the bacterial transcription machinery. In contrast, however, a number of genes for the archaeal transcription apparatus are organized in clusters resembling the clusters of transcription-associated genes in Bacteria.
Postallogeneic monitoring with molecular markers detected by pretransplant next‐generation or Sanger sequencing predicts clinical relapse in patients with myelodysplastic/myeloproliferative neoplasms (2013)

Relapse is the major cause of treatment failure after allogeneic stem-cell transplantation (AHSCT) for patients with myelodysplastic syndrome/myeloproliferative syndrome neoplasms (MDS/MPN). We evaluated the impact of molecular mutations on outcome and the value of molecular monitoring post-transplantation. We screened 45 patients with chronic myelomonocytic leukemia (n = 39 patients, including seven with transformed-acute myeloid leukemia), MDS/MPN unclassifiable (n = 5), and atypical BCR-ABL1-negative CML (n = 1) for mutations in ASXL1, CBL, NRAS, and TET2 genes by molecular genetics including a sensitive next-generation sequencing (NGS) technique. In 36 patients, sufficient DNA was available for molecular analyses. In particular, TET2 and CBL mutations were screened applying amplicon deep sequencing. In 89% of cases, at least one mutation could be detected: ASXL1: n = 18 (50%); CBL: n = 7 (19%); TET2: n = 15 (42%); and NRAS: n = 11 (32%). Survival after AHSCT at 5 yr was 46% (95% CI 28-64%) and was not influenced by any mutation. After a median of 6 months after AHSCT in 33% of the patients, one of the molecular markers was still detectable, resulting in a higher incidence of relapse than in patients with undetectable mutations (50% vs. 15%, P = 0.04). In conclusion, pretransplant molecular mutation analysis can help to detect biomarkers in patients with MPN/MDS, which may be subsequently used as minimal residual disease markers after AHSCT.
From Retinex to Automatic Color Equalization: issues in developing a new algorithm for unsupervised color equalization (2004)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin (2006)

Despite considerably higher plasma pravastatin concentrations in carriers of an SLCO1B1 variant haplotype, there was no significant difference in the lipid-lowering efficacy of pravastatin between the variant haplotype and control groups. However, this pilot study had sufficient statistical power to detect only a large difference in lipid response between the 2 groups. Further clinical studies are warranted to characterize the impact of the SLCO1B1 polymorphism on the lipid response to pravastatin.
A MEMS stage for 3-axis nanopositioning (2007)

Applications in micro- and nanotechnologies require millimeter-sized devices that are capable of 3-axis positioning with motion ranges of micrometers and resolutions of nanometers. This paper reports on the design, fabrication and testing of a MEMS-based 3-axis positioning stage. In-plane (comb-drive) and out-of-plane (parallel-plate) electrostatic actuators are employed for driving the stage to move independently along the XYZ directions, by ±12.5 µm in the X and Y directions at an actuation voltage of 30 V and by 3.5 µm in the Z direction at 14.8 V. The structures are designed to achieve highly decoupled motions by effectively suppressing cross-axis motion coupling. The open-loop positioning repeatability is determined to be better than 17.3 nm along all three axes.
A new current-mode sense amplifier for low-voltage low-power SRAM (2002)

A new current-mode sense amplifier is proposed and it can be used in the design of a low-voltage low-power SRAM for ASIC applications. In the new current-mode sense amplifier a modified current-conveyor is used to prevent the pattern dependent problem which is overlooked in the previous designs. Simulation results show the conventional circuits will fail and the new circuit can work if V/sub DD/=1.5 V and an industrial 0.35 /spl mu/m CMOS technology is used. Power consumption of the new circuit with V/sub DD/=1.5 V is only 6%/spl sim/39% of the conventional circuits running at V/sub DD/=2.0 V. A 128/spl times/8 SRAM using the new circuit for V/sub DD/=2.0 V in a 0.6 /spl mu/m CMOS technology is also designed and successfully applied in an 8-bit low-power microcontroller.
Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment (2014)

Cognitive dysfunction has been reported in patients with spinal cord injury (SCI), but it has been questioned whether such changes may reflect concurrent head injury, and the issue has not been addressed mechanistically or in a well-controlled experimental model. Our recent rodent studies examining SCI-induced hyperesthesia revealed neuroinflammatory changes not only in supratentorial pain-regulatory sites, but also in other brain regions, suggesting that additional brain functions may be impacted following SCI. Here we examined effects of isolated thoracic SCI in rats on cognition, brain inflammation, and neurodegeneration. We show for the first time that SCI causes widespread microglial activation in the brain, with increased expression of markers for activated microglia/macrophages, including translocator protein and chemokine ligand 21 (C-C motif). Stereological analysis demonstrated significant neuronal loss in the cortex, thalamus, and hippocampus. SCI caused chronic impairment in spatial, retention, contextual, and fear-related emotional memory-evidenced by poor performance in the Morris water maze, novel objective recognition, and passive avoidance tests. Based on our prior work implicating cell cycle activation (CCA) in chronic neuroinflammation after SCI or traumatic brain injury, we evaluated whether CCA contributed to the observed changes. Increased expression of cell cycle-related genes and proteins was found in hippocampus and cortex after SCI. Posttraumatic brain inflammation, neuronal loss, and cognitive changes were attenuated by systemic post-injury administration of a selective cyclin-dependent kinase inhibitor. These studies demonstrate that chronic brain neurodegeneration occurs after isolated SCI, likely related to sustained microglial activation mediated by cell cycle activation.
The physics of paper (2006)

Paper is a material known to everybody. It has a network structure consisting of wood fibres that can be mimicked by cooking a portion of spaghetti and pouring it on a plate, to form a planar assembly of fibres that lie roughly horizontal. Real paper also contains other constituents added for technical purposes.
Meta-Analysis of Phase II Cooperative Group Trials in Metastatic Stage IV Melanoma to Determine Progression-Free and Overall Survival Benchmarks for Future Phase II Trials (2008)

Benchmarks are provided for 1-year OS or OS curves that make use of the distribution of prognostic factors of the patients in the phase II trial. A similar benchmark for 6-month PFS is provided, but its use is more problematic because of residual between-trial variation in this endpoint.
Silkworm Pupae (Bombyx mori) Are New Sources of High Quality Protein and Lipid (2010)

This study was performed to evaluate the nutritional value of silkworm pupae (Bombyx mori) and the content of α-glucosidase inhibitor. The percentages of total protein and lipid contents by dry weight were 55.6 and 32.2%, respectively. Silkworm pupae protein had high levels of essential amino acids such as valine, methionine and phenylalanine. The contents of essential amino acids in silkworm pupae protein satisfied the FAO/WHO/UNU suggested requirements (2007). In addition, they also possessed n-3 fatty acids, especially α-linolenic acid (36.3%), as a major component. The 50% ethanol extract of silkworm pupae contained 1-deoxynojirimycin (DNJ), which is a potent α-glucosidase inhibitor. These results suggest that silkworm pupae are a new source of high quality protein, lipid, and α-glucosidase inhibitor.
Can God Be an AI With Robo-Priests? (2023)

“You may love your computer, but your computer [and AI] do not love you” (Kallistos Ware) <xref ref-type="bibr" rid="ref1" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[1, p. 26]</xref> .
Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection (2013)

Initial studies have clarified the potential for a lesser-known Vitamin B3 called nicotinamide riboside that is available in selected foods, and possibly available to humans by supplements. It has properties that are insulin sensitizing, enhancing to exercise, resisting to negative effects of high-fat diet, and neuroprotecting.