gebhart/patrepeval huggingface dataset:
The Chemistry of Neutron Capture Therapy (1998)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of Neutron Capture TherapyAlbert H. Soloway, Werner Tjarks, Beverly A. Barnum, Feng-Guang Rong, Rolf F. Barth, Iwona M. Codogni, and J. Gerald WilsonView Author Information College of Pharmacy, Department of Pathology, and The Comprehensive Cancer Center of The Ohio State University, The Ohio State University, Columbus, Ohio 43210 Cite this: Chem. Rev. 1998, 98, 4, 1515–1562Publication Date (Web):May 20, 1998Publication History Received29 October 1997Revised13 April 1998Published online20 May 1998Published inissue 1 June 1998https://pubs.acs.org/doi/10.1021/cr941195uhttps://doi.org/10.1021/cr941195uresearch-articleACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views5318Altmetric-Citations1007LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Boron,Cancer,Cells,Peptides and proteins,Tumors Get e-Alerts
The gene for a novel protein, a member of the protein disulphide isomerase/form I phosphoinositide-specific phospholipase C family, is amplified in hydroxyurea-resistant cells (1992)

Cell lines selected in multiple steps for increasing resistance to hydroxyurea have been shown to have corresponding increases in ribonucleotide reductase activity. We have isolated a number of cDNA clones from a cDNA library constructed from a highly hydroxyurea-resistant hamster cell line, 600H, in which the activity of ribonucleotide reductase is elevated more than 80-fold. These clones correspond to genomic DNA sequences amplified in the 600H cell line compared with the V79 parental line. One of these cDNA clones, termed P5, codes for a 50 kDa protein detected by in vitro translation of poly(A)+ RNA isolated by hybridization/selection. The cDNA sequence contains a single open reading frame of 1317 nucleotides which encodes a polypeptide of 439 amino acids. The amino acid sequence deduced from the cDNA insert contains two copies of the 11-amino-acid sequence Val-Glu-Phe-Tyr-Ala-Pro-Trp-Cys-Gly-His-Cys. Duplicate copies of this sequence also occur in the active site of rat and human protein disulphide isomerase (also known as the beta-subunit of human prolyl 4-hydroxylase, tri-iodothyronine-binding protein) and in Form I phosphoinositide-specific phospholipase C, indicating that P5 falls into this newly defined superfamily of proteins. Genomic sequences similar to the cDNA clone are amplified 10-20-fold in hamster cells selected for resistance to increasing concentrations of hydroxyurea, a phenomenon observed earlier with cDNA clones for the M2 subunit of ribonucleotide reductase and ornithine decarboxylase. RNA blots probed with P5 cDNA show two poly(A)+ RNA species which are elevated in hydroxyurea-resistant cells.
Validation of a Virtual Assistant for Improving Medication Adherence in Patients with Comorbid Type 2 Diabetes Mellitus and Depressive Disorder (2021)

Virtual assistants are programs that interact with users through text or voice messages simulating a human-based conversation. The development of healthcare virtual assistants that use messaging platforms is rapidly increasing. Still, there is a lack of validation of these assistants. In particular, this work aimed to validate the effectiveness of a healthcare virtual assistant, integrated within messaging platforms, with the aim of improving medication adherence in patients with comorbid type 2 diabetes mellitus and depressive disorder. For this purpose, a nine-month pilot study was designed and subsequently conducted. The virtual assistant reminds patients about their medication and provides healthcare professionals with the ability to monitor their patients. We analyzed the medication possession ratio (MPR), measured the level of glycosylated hemoglobin (HbA1c), and obtained the patient health questionnaire (PHQ-9) score in the patients before and after the study. We also conducted interviews with all participants. A total of thirteen patients and five nurses used and evaluated the proposed virtual assistant using the messaging platform Signal. Results showed that on average, the medication adherence improved. In the final interview, 69% of the patients agreed with the idea of continuing to use the virtual assistant after the study.
Bacopaside III, Bacopasaponin G, and Bacopasides A, B, and C from <i>Bacopa monniera</i> (2002)

Two new saponins, 3-O-[6-O-sulfonyl-beta-d-glucopyranosyl-(1-->3)]-alpha-l-arabinopyranosyl pseudojujubogenin (1) and 3-O-[alpha-l-arabinofuranosyl-(1-->2)]-alpha-l-arabinopyranosyl jujubogenin (2), a new matsutaka alcohol derivative, (3R)-1-octan-3-yl-(6-O-sulfonyl)-beta-d-glucopyranoside (3), a new phenylethanoid glycoside, 3,4-dihydroxyphenylethyl alcohol (2-O-feruloyl)-beta-d-glucopyranoside (4), and a new glycoside, phenylethyl alcohol [5-O-p-hydroxybenzoyl-beta-d-apiofuranosyl-(1-->2)]-beta-d-glucopyranoside (5), were isolated from Bacopa monniera. Their structures were established by NMR, MS, and chemical methods.
Turning date palm waste into carbon nanodots and nano zerovalent iron composites for excellent removal of methylthioninium chloride from water (2020)

Abstract Novel carbon nanodots (nCD-DBC) and nano zero-valent iron composites (nZVI-DBC) were synthesized using date palm waste-derived biochar (DBC). The synthesized materials were analyzed for chemical and structural composition by using FTIR, SEM, XRD, and TGA, and evaluated for their methylthioninium chloride dye (MB) removal efficiency from contaminated aqueous solutions. pH 7.0 was found optimum for the highest MB removal in sorption batch studies. Kinetics sorption of MB onto the sorbents was best described by pseudo-second-order ( R 2 = 0.93–0.99) and Elovich models ( R 2 = 0.86–0.97) implying that sorption was being controlled by chemisorption. Langmuir model predicted maximum sorption capacities for nCD-DBC, nZVI-DBC, and DBC were 1558.66, 1182.90, and 851.67 mg g −1 , respectively, which correlated with the results of kinetics sorption. Likewise, nCD-DBC yielded the highest partition coefficient (7067 mL g −1 ), followed by nZVI-DBC (1460 mL g −1 ), and DBC (930 mL g −1 ). Post-sorption XRD, FTIR, and SEM analyses depicted the binding of MB onto the sorbents. It was suggested that electrostatic interactions, π–π electron donor-accepter interactions, degradation, and diffusion were responsible for MB removal by the synthesized materials. Therefore, the nCD-DBC, nZVI-DBC, and DBC can potentially be used for scavenging MB dye from contaminated aqueous solutions.
Heralded single-pixel imaging with high loss-resistance and noise-robustness (2021)

Imaging with non-classically correlated photon-pairs takes advantages over classical limits in terms of sensitivity and a signal-to-noise ratio. However, it is still a challenge to achieve a strong resilience to background noise and losses for practical applications. In this work, we present heralded single-pixel imaging that is remarkably robust against bright background noise and severe signal losses. Using a strong temporal correlation between a photon-pair and joint measurement-based imaging method, we achieve the suppression of noise up to 1000 times larger than the signal and also demonstrate the correlation-induced SNR enhancement factor of over 200 against 70 times larger noise and a 90% signal loss compared to non-time-gated classical imaging. Our work enables correlated imaging with a highly scalable photon capacity.
Magnetic particle imaging using linear magnetization response-driven harmonic signal of magnetoresistive sensor (2021)

Abstract We achieved a harmonic-rich signal from linear magnetization responses of magnetic nanoparticles under 40 μ T/ μ 0 excitation field to facilitate magnetic particle imaging (MPI). In contrast, large harmonic responses are typically attributed to the nonlinear field-dependent magnetization characteristics of the particles, thus questioning technical and clinical issues toward a human-sized MPI scanner. By using a magnetoresistive sensor, we propose a strategy to exploit the linear responses of the tracers at low field regime where the standard MPI may struggle with spatial signal decoding. The achieved high-contrast images of a solid ferucarbotran phantom bring new expectation toward clinical use of MPI.
A Simplified Model for Pavement Drainage (2001)

In this paper, we present a simplified model for pavement drainage system. The model accounts for the accumulation and flow of water through a drainable base and edge drain representing a porous medium. There is an inflow through a portion of the boundary (pavement surface) as well as an outflow through a separate part of the boundary (outlet pipe). The model consists of an initial value problem governing the growth of the region saturated with water and an elliptic boundary value problem describing the flow of water within that region. The model is validated using rainfall and outflow data obtained from an instrumented site. The proposed model can be used to evaluate the characteristics of a pavement drainage system as well as to estimate its permeability.
Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation (2014)

Aberrant microglial responses contribute to neuroinflammation in many neurodegenerative diseases, but no current therapies target pathogenic microglia. We discovered unexpectedly that the antiviral drug ganciclovir (GCV) inhibits the proliferation of microglia in experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis (MS), as well as in kainic acid-induced excitotoxicity. In EAE, GCV largely prevented infiltration of T lymphocytes into the central nervous system (CNS) and drastically reduced disease incidence and severity when delivered before the onset of disease. In contrast, GCV treatment had minimal effects on peripheral leukocyte distribution in EAE and did not inhibit generation of antibodies after immunization with ovalbumin. Additionally, a radiolabeled analogue of penciclovir, [(18)F]FHBG, which is similar in structure to GCV, was retained in areas of CNS inflammation in EAE, but not in naive control mice, consistent with the observed therapeutic effects. Our experiments suggest GCV may have beneficial effects in the CNS beyond its antiviral properties.
Molecular Cloning and Expression of a Gene Encoding a Novel Sorbitol Oxidase from<i>Streptomyces</i>sp. H-7775 (1998)

A gene encoding a novel intracellular sorbitol oxidase of a soil bacterium, Streptomyces sp. H-7775, was cloned and sequenced. The gene consists of an open reading frame of 1,260-bp encoding a protein of 420 amino acids with a molecular weight of 45,148. Deduced amino acid sequence of the gene has 25.3% identity and 68.1% similarity to that of rat L-gulonolactone oxidase at the overall amino acids. Nucleotide-binding motifs were not found in the deduced amino acid sequence of SOX protein. We succeeded in expressing recombinant sorbitol oxidase with covalently bound FAD in E. coli at about a 4,000-fold higher total enzyme activity than that of the Streptomyces sp. H-7775. The enzymatic properties of the recombinant SOX were similar to those of the enzyme from Streptomyces sp. H-7775. This is the first report of the cloning and expression of a newly categorized enzyme, sorbitol oxidase, from Streptomyces sp.
Improved growth and thermal stability of Parylene films (1997)

Experimental results for the deposition of low dielectric constant Parylene-N and Parylene-F films are explained by a mechanism based on bulk phase diffusion reaction in the film. The deposition rate of Parylene-F decreases significantly as time increases and ultimately achieves steady state. Very favorable agreement with experiments at a substrate temperature of −10 °C is obtained for parylene-F with a rate constant of kf=5×10−5/s, and a diffusion coefficient Df=1.3×10−8 cm2/s. In contrast, the much higher rate constant at room temperature for Parylene-N films is kf=0.16/s and the predicted deposition rate is constant after a very small period of time (tss&lt;4/kf=25 s). This prediction is confirmed by the experiments. The model predicts correctly that low deposition temperatures improve both the deposition rate and thermal stability of Parylene films. Our experiments confirm this prediction and one obtains both high growth rates and high molecular weight films at lower deposition temperatures. Furthermore, experiments show that the longer chains formed at low temperatures significantly improve the thermal stability of the films. The deposition rate also can be improved by using higher reactor pressures. However, the pressure that can be employed is limited to about 100 mTorr to maintain high quality films. At liquid nitrogen temperature (77 K), the deposition rate is three orders of magnitude larger than the film deposition rate at room temperature. The increased monomer concentration on the substrate due to higher condensation leads to this increased deposition rate.
Circulating microRNAs as potential biomarkers for unstable angina. (2017)

Circulating miRNAs were upregulated in UA compared with the control group. The combination of the modified HEART score (m-HS) and miR-25 (AUC 0.901, NRI 0.096) could better distinguish UA than m-HS alone. Bioinformatic analysis indicated that miRNAs may take part in platelet activation, cGMP-PKG signaling pathways etc. Conclusion: The circulating levels of miRNAs (miR-21, miR-25, miR-106b, miR-126*) are significantly higher in UA patients compared with patients with NICP, and the addition of the m-HS that combined ECG, age, risk factors and troponin is useful to detect or rule out UA. The associated signaling pathways are involved in the pathogenesis of vulnerable plaque.
Low loss germanium-on-silicon waveguides for integrated mid-infrared photonics (2019)

Low loss Ge-on-Si waveguides are demonstrated in the 8 – 14 μm atmospheric transmission window, a technology that will enable detection and sensing of unique molecular vibrations. Such a low cost platform would have applications in key markets such as pollution monitoring, explosives detection and point of care diagnostics. Rib-waveguides are fabricated using electron beam lithography and dry etching. The waveguides propagation losses are characterized using the Fabry-Perot technique, and are found to be below 5 dB/cm across the measurement range of 7.5 to 11 μm wavelength, reaching as low as ~ 1 dB/cm. The contribution to the losses are analyzed using the experimentally measured Si substrate losses, and the calculated scattering losses from an analytical model. The results verify the feasibility of the Ge-on-Si platform for integrated mid-infrared photonics and sensing.
Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation (2010)

Maintenance of genomic methylation patterns is mediated primarily by DNA methyltransferase-1 (DNMT1). We have solved structures of mouse and human DNMT1 composed of CXXC, tandem bromo-adjacent homology (BAH1/2), and methyltransferase domains bound to DNA-containing unmethylated CpG sites. The CXXC specifically binds to unmethylated CpG dinucleotide and positions the CXXC-BAH1 linker between the DNA and the active site of DNMT1, preventing de novo methylation. In addition, a loop projecting from BAH2 interacts with the target recognition domain (TRD) of the methyltransferase, stabilizing the TRD in a retracted position and preventing it from inserting into the DNA major groove. Our studies identify an autoinhibitory mechanism, in which unmethylated CpG dinucleotides are occluded from the active site to ensure that only hemimethylated CpG dinucleotides undergo methylation.
Assumptions on the Re-study of Textiles and Clothing in the Newspapers and Periodicals of the Republic of China (2022)

The development of textile and clothing in the Republic of China plays an important role in history, which is the demarcation point between ancient and modern, and also the intersection point between the East and the West. Based on the research on the textile and clothing during this period in the newspapers and periodicals of the Republic of China, and it has many advantages such as time certainty, material diversity, and content authenticity, etc. Therefore, the textile and clothing information in the newspapers and periodicals of the Republic of China plays an important role in understanding the development of the textile and clothing in the Republic of China. Through the analysis of the research value and research status, we can further refine the research content, optimize the research method, clarify the research goal and provide a feasible research path. And then which will provide a useful reference for follow-up studies, film and television production, and the development of local intangible cultural heritage.
Qualitative reasoning-based parameter tuning on bottleneck of synchronized queueing network (2002)

The qualitative method is proposed for parameter tuning of synchronized queuing network bottlenecks (SQN). The bottleneck diagnosis expert system for SQN (BDES-S) can carry out parameter tuning in order to diagnose and improve bottlenecks of SQN. BDES-S can produce several alternative qualitative improvement plans for the bottleneck. BDES-S is a novel system for applying the qualitative reasoning to the SQN. >
FDA Approval Summary: Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma with Disease Progression on or After Platinum-Containing Chemotherapy (2017)

This accelerated approval expands the U.S. Food and Drug Administration-approved indications for pembrolizumab, providing health care providers with new information regarding pembrolizumab for the treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) with disease progression on or after platinum-containing chemotherapy. Pembrolizumab is the first drug to receive approval for treatment of patients with HNSCC since cetuximab was approved for this indication in 2006.
Neural prostheses for walking restoration (2008)

We review the state of the art of multi-channel electrical stimulation (ES) systems with surface electrodes for assistance in the standing and walking of paraplegics and hemiplegics. For the group of complete paraplegics, walking achieved with available ES systems is below their expectations, especially since these systems cannot compete with mobility provided to them by a wheelchair. However, standing and walking with ES systems are beneficial because they contribute to the improvement of physiological functions. For individuals who can stand with some arm support (e.g., paraplegics with incomplete injury and hemiplegics), the current ES systems are an effective augmentation of walking. We suggest that an ES system for walking of incomplete paraplegics and hemiplegics will be better accepted if the stimulation is regulated by a rule-based control, that is, a preprogrammed, sensor-triggered activation of several muscles resulting in normal walking. We present a method to obtain muscle activity profiles from simulation of a customized model of the patient that can be used for the synthesis of rules for control.
A fully decentralized algorithm to timestamping transactions in a peer-to-peer environments (2010)

In this paper, we investigate a decentralized approach to timestamping transactions in a replicated database, under partial replication in Peer-To-Peer (P2P) environments. In order to solve problems of concurrent updates and node failures, we propose an architecture based on quorums, this architecture allows assigning a unique timestamp to each distributed transaction, to select the servers replicas and to coordinate the distributed execution of the transaction.
Accelerated weight histogram method for exploring free energy landscapes (2014)

Calculating free energies is an important and notoriously difficult task for molecular simulations. The rapid increase in computational power has made it possible to probe increasingly complex systems, yet extracting accurate free energies from these simulations remains a major challenge. Fully exploring the free energy landscape of, say, a biological macromolecule typically requires sampling large conformational changes and slow transitions. Often, the only feasible way to study such a system is to simulate it using an enhanced sampling method. The accelerated weight histogram (AWH) method is a new, efficient extended ensemble sampling technique which adaptively biases the simulation to promote exploration of the free energy landscape. The AWH method uses a probability weight histogram which allows for efficient free energy updates and results in an easy discretization procedure. A major advantage of the method is its general formulation, making it a powerful platform for developing further extensions and analyzing its relation to already existing methods. Here, we demonstrate its efficiency and general applicability by calculating the potential of mean force along a reaction coordinate for both a single dimension and multiple dimensions. We make use of a non-uniform, free energy dependent target distribution in reaction coordinate space so that computational efforts are not wasted on physically irrelevant regions. We present numerical results for molecular dynamics simulations of lithium acetate in solution and chignolin, a 10-residue long peptide that folds into a β-hairpin. We further present practical guidelines for setting up and running an AWH simulation.
Fully Transparent Pixel Circuits Driven by Random Network Carbon Nanotube Transistor Circuitry (2010)

Optically transparent and mechanically flexible thin-film transistors have recently attracted attention for next generation transparent display technologies. Driving and switching transistors for transparent displays have challenging requirements such as high optical transparency, large-scale integration, suitable drive current (I(on)) in the microampere range, high on/off current ratio (I(on)/I(off)), high field-effect mobility, and uniform threshold voltage (V(th)). In this study, we demonstrate fully transparent high-performance and high-yield thin-film transistors based on random growth of a single-walled carbon nanotube (SWNT) network that are easy to fabricate. High-performance SWNT-TFTs exhibit optical transmission of 80% in visible wavelength, I(on)/I(off) higher than 10(3), and a high yield with reproducible electrical characteristics.
<sup>13</sup>C and<sup>15</sup>N NMR study of acyclic vicinal diastereoisomers. Conformational effects (1980)

Abstract Conformations of aliphatic diastereoisomers with vicinal asymmetric centers (2,3‐disubstituted butanes and 5,6‐disubstituted n ‐decanes) are discussed in terms of their 13 C and, in some cases, 15 N chemical shifts and spin‐lattice relaxation times. Solvent and protonation effects are explained by conformational changes in the isomers.