gebhart/patrepeval huggingface dataset:
Lithium Reserve Battery. (1974)

Abstract : The purpose of the contract was to design, develop and deliver a complete Lithium Organic Electrolyte Reserve Battery including activation mechanism to an initial specified configuration. An amendment to the scope of work was added to the contract to determine the causes for stability of a particular electrolyte formulation and also to generate material specifications that will sufficiently describe and control the important characteristics of the electrolyte and constituent materials. The choice of electrolyte was based in part on the results obtained from comprehensive studies concerning the high temperature stability of 2M LiAsF6/MF electrolyte solutions. It was found that the addition of small amounts of LiBF4 to these solutions greatly increased their high temperature storage capabilities. It was determined that the LiBF4 was effective only when lithium metal was also present in the solution. LiBF4 was able to stabilize solutions prepared with grades of LiAsF6 obtained from other vendors but to a much lesser degree.
Development and Evaluation of a Hole-Punch Applicator for Precision Application of Preemergence Herbicides in Plasticulture Production (2018)

Abstract Preemergence herbicides are typically applied by broadcasting to the top of raised beds before laying the plastic mulch in plasticulture production systems. Broadleaf and grass emergence is limited to transplant holes in the mulch. As a result, most herbicides are applied under the mulch in locations where weeds cannot emerge and herbicides are unnecessary. To reduce this excessive off-target application, a precision hole-punch sprayer was developed at the University of Florida for use in plasticulture production systems. The technology facilitates the application of herbicides during the hole-punch operation immediately before transplant. Application of napropamide and S -metolachlor in an application volume of 233 L ha −1 of water using the precision hole-punch applicator had no effect on tomato and bell pepper growth and yield. Equipment accuracy ranged from 55% to 90%. Preemergence herbicide use was reduced by 88% to 92% with no reduction in weed control. The hole-punch applicator is an effective way to reduce PRE herbicide use in transplant vegetables grown using the plasticulture production system.
Tunnel oxide prepared by thermal oxidation of thin polysilicon film on silicon (TOPS) (1993)

A textured tunnel oxide, TOPS, prepared by thermally oxidizing a thin polysilicon film on a Si substrate is reported. Due to the rapid diffusion of oxygen through the grain boundaries of the thin polysilicon into Si substrate and the enhanced oxidation rate at the grain boundaries, a textured Si-SiO/sub 2/ interface is obtained. The textured interface results in localized high fields and enhances electron injection into TOPS. TOPS exhibits a higher electron injection efficiency, a better immunity to the electron trapping and interface state generation under high-field operation, and a higher asymmetric injection polarity than the normal oxide.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs (2013)

This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype. The observation that 3/33 dogs developed DCM and lacked the striatin mutation suggests that there is at least 1 other cause of DCM in the Boxer dog.
Isolation, Expansion, and Characterization of Human Natural and Adaptive Regulatory T Cells (2007)

Regulatory T cells play a central role in controlling homeostasis, and in inducing and maintaining tolerance to both foreign and self-antigens. Several types of T cells with regulatory activity have been described both in mice and humans, and those within the CD4+ subset have been extensively studied. Among them, the best characterized are the naturally occurring CD4+CD25+ regulatory T (Treg) cells, and the adaptive type 1 regulatory T (Tr1) cells. Natural Treg cells can arise directly from the thymus, are characterized by the constitutive expression of the transcription factor Foxp3, and suppress T cell responses in a cell-cell contact mediated mechanism. On the contrary, adaptive Tr1 cells arise in the periphery upon encountering antigen in a tolerogenic environment, produce high levels of interleukin (IL)-10 and mediate suppression via IL-10. During the last decade, much effort has been placed on developing protocols to generate regulatory T-cell lines and clones, to further define the similarities and differences between various regulatory T-cell subsets. In this chapter, we will outline protocols to expand naturally occurring Treg cells, to differentiate homogeneous population of Tr1 cells in vitro, and to generate natural Treg and Tr1 cell clones and cell lines.
Bow musical instrument made of composite material (1993)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Charles Besnainou, Stephane Vaiedelich; Bow musical instrument made of composite material. J. Acoust. Soc. Am. 1 June 1993; 93 (6): 3542. https://doi.org/10.1121/1.405349 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Abstract 3551: Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines (2016)

Abstract Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that regulate apoptosis. Amplification of Mcl-1 is found in various cancers, which causes the evasion of apoptosis and is one of the major resistance mechanisms for many chemotherapies. Mcl-1 mediates its effects primarily through high affinity interactions with pro-apoptotic BH3 containing proteins, Bak and Bax. Thus targeting Mcl-1 with small molecule inhibitors is a promising strategy but a very challenging task. Using fragment-based methods and structure-based design, we discovered a novel class of potent Mcl-1 inhibitors that exhibit selective anti-proliferative activity. New leads containing a tricyclic indole lactam scaffold exhibited dissociation constants of &lt;0.5 nM with &gt;1000-fold selectivity for Mcl-1 over Bcl-xL and Bcl-2. They also promoted apoptosis only in Mcl-1 sensitive cancer cell lines by activating caspases in a dose-dependent manner. These results provide a strong proof of concept for a selective inhibition of Mcl-1 function as an effective anti-cancer therapy. Finally, our leads also possess desirable pharmaceutical properties including in vivo oral bioavailability and represent an ideal starting point for developing clinically useful Mcl-1 inhibitors for the treatment of a wide variety of cancers. Citation Format: Taekyu Lee, Zhiguo Bian, Johannes Belmar, Subrata Shaw, James C. Tarr, Bin Zhao, Nick Pelz, DeMarco Camper, Craig M. Goodwin, Allison L. Arnold, John L. Sensintaffar, Carrie F. Browning, Olivia W. Rossanese, Edward T. Olejniczak, Stephen W. Fesik. Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3551.
N-Polar GaN Cap MISHEMT With Record Power Density Exceeding 6.5 W/mm at 94 GHz (2017)

A novel N-Polar GaN cap (MIS)high electron mobility transistor demonstrating record 6.7-W/mm power density with an associated power-added efficiency of 14.4% at 94 GHz is presented. This state-of-the-art power performance is enabled by utilizing the inherent polarization fields of N-Polar GaN in combination with a 47.5-nm in situ GaN cap layer to simultaneously mitigate dispersion and improve access region conductivity. These excellent results build upon past work through the use of optimized device dimensions and a transition from a sapphire to a substrate for reduced self-heating.
Code-conversion method and apparatus for analyzing and synthesizing human speech (1992)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Takao Nakajima, Hiroshi Shigehara; Code‐conversion method and apparatus for analyzing and synthesizing human speech. J. Acoust. Soc. Am. 1 November 1992; 92 (5): 3028. https://doi.org/10.1121/1.404308 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Trapping artifacts in quasi-steady-state photoluminescence and photoconductance lifetime measurements on silicon wafers (2006)

Photoluminescence and photoconductance lifetime measurements on multicrystalline silicon wafers are presented. It is demonstrated experimentally that the large overestimation of the lifetime at low carrier concentrations due to trapping that is observed in photoconductance measurements is not found in photoluminescence data. This is explained theoretically by the dependence of photoluminescence and photoconductance on the product and the sum, respectively, of the minority and majority carrier densities. Based on this analysis, it is shown that photoluminescence lifetime measurements are not significantly affected by minority carrier trapping in most practical cases while implied current-voltage curves obtained from photoluminescence are completely unaffected.
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1 (2021)

A diaryl ketone series was identified as vanin-1 inhibitors from a high-throughput screening campaign. While this novel scaffold provided valuable probe <b>2</b> that was used to build target confidence, concerns over the ketone moiety led to the replacement of this group. The successful replacement of this moiety was achieved with pyrimidine carboxamides derived from cyclic secondary amines that were extensively characterized using biophysical and crystallographic methods as competitive inhibitors of vanin-1. Through optimization of potency and physicochemical and ADME properties, and guided by co-crystal structures with vanin-1, <b>3</b> was identified with a suitable profile for advancement into preclinical development.
New method for scanning spacecraft and balloon-borne/space-based experiments (1991)

A new method is presented for scanning balloon-borne experiments, free-flying spacecraft, and gimballed experiments mounted to the space shuttle or the space station. It uses rotating-unbalanced-mass (RUM) devices for generating circular, line, or raster scan patterns and an auxiliary control system for target acquisition, keeping the scan centered on the target, and producing complementary motion for raster scanning. It is ideal for applications where the only possible way to accomplish the required scan is to physically scan the entire experiment or spacecraft as in X-ray and gamma ray experiments. In such cases, this new method should have advantages over prior methods in terms of either power, weight, cost, performance, stability, or a combination of these.
A Ceramic Capacitor Substrate for High Speed Switching VLSI Chips (1982)

An integrated capacitor substrate which is proposed as an essential part in the realization of a thin film module for high speed digital computing systems is discussed. Several innovative multilayer ceramic (MLC) concepts relative to the fabrication of the desired low inductance capacitor and current paths to chips are described. Ceramic and metal composite material sets which may be used in the fabrication are also proposed. Experimental evaluations of some of the crucial concepts were made and included in the discussions. The result is an elegant approach to the fabrication of one of the key requirements in realizing the thin film high performance module.
Photovoltaic inverter controllers seeking AC optimal power flow solutions (2017)

This paper considers future distribution networks featuring inverter-interfaced photovoltaic (PV) systems, and addresses the synthesis of feedback controllers that seek real- and reactive-power inverter setpoints corresponding to AC optimal power flow (OPF) solutions. The objective is to bridge the temporal gap between long-term system optimization and real-time inverter control, and enable seamless PV-owner participation without compromising system efficiency and stability. The design of the controllers is grounded on a dual ϵ-subgradient method, and semidefinite programming relaxations are advocated to bypass the non-convexity of AC OPF formulations. Global convergence of inverter output powers is analytically established for diminishing stepsize rules for cases where: i) computational limits dictate asynchronous updates of the controller signals, and ii) inverter reference inputs may be updated at a faster rate than the power-output settling time.
Long-range GPS-denied aerial inertial navigation with LIDAR localization (2016)

Despite significant progress in GPS-denied autonomous flight, long-distance traversals (> 100 km) in the absence of GPS remain elusive. This paper demonstrates a method capable of accurately estimating the aircraft state over a 218 km flight with a final position error of 27 m, 0.012% of the distance traveled. Our technique efficiently captures the full state dynamics of the air vehicle with semi-intermittent global corrections using LIDAR measurements matched against an a priori Digital Elevation Model (DEM). Using an error-state Kalman filter with IMU bias estimation, we are able to maintain a high-certainty state estimate, reducing the computation time to search over a global elevation map. A sub region of the DEM is scanned with the latest LIDAR projection providing a correlation map of landscape symmetry. The optimal position is extracted from the correlation map to produce a position correction that is applied to the state estimate in the filter. This method provides a GPS-denied state estimate for long range drift-free navigation. We demonstrate this method on two flight data sets from a full-sized helicopter, showing significantly longer flight distances over the current state of the art.
Heavy-Ion and Total Ionizing Dose (TID) Performance of a 1 Mbit Magnetoresistive Random Access Memory (MRAM) (2009)

An MRAM is a nonvolatile memory that has been demonstrated and supports heavy ion immunity to an LET of approximately 69 MeV-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /mg for fluences to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> ions/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ; and TED hardness in excess of 1 Mrad.
Improved sampling of myocardial motion with variable separation tagging (1998)

A novel tagging method is introduced that increases the spatial resolution of estimates of myocardial radial thickening. The separation of adjacent parallel tag planes is customized to match the expected motion of specific regions of the heart wall. In regions in which the tags increase their separation over systole (radial thickening), the tag planes are placed close together at end diastole. In regions in which the tags decrease their separation over systole (circumferential shortening), the tags are placed farther apart so they remain detectable at end systole. With variable separation tagging (VTAG), parallel plane tagging can be used to obtain higher-resolution estimates of radial thickening and circumferential shortening simultaneously.
Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative Disorders (1986)

A novel human B-lymphotropic virus (HBLV) was isolated from the peripheral blood leukocytes of six individuals: two HTLV-III seropositive patients from the United States (one with AIDS-related lymphoma and one with dermatopathic lymphadenopathy), three HTLV-III seronegative patients from the United States (one with angioimmunoblastic lymphadenopathy, one with cutaneous T-cell lymphoma, and one with immunoblastic lymphoma), and one HTLV-III seronegative patient with acute lymphocytic leukemia from Jamaica. All six isolates were closely related by antigenic analysis, and sera from all six virus-positive patients reacted immunologically with each virus isolate. In contrast, only four sera from 220 randomly selected healthy donors and none from 12 AIDS patients without associated lymphoma were seropositive. The virus selectively infected freshly isolated human B cells and converted them into large, refractile mono- or binucleated cells with nuclear and cytoplasmic inclusion bodies. HBLV is morphologically similar to viruses of the herpesvirus family but is readily distinguishable from the known human and nonhuman primate herpesviruses by host range, in vitro biological effects, and antigenic features.
Precessional reversal in orthogonal spin transfer magnetic random access memory devices (2012)

Single-shot time-resolved resistance measurements have been used to determine the magnetization reversal mechanisms of orthogonal spin transfer magnetic random access memory (OST-MRAM) devices at nanosecond time scales. There is a strong asymmetry between antiparallel (AP) to parallel (P) and P to AP transitions under the same pulse conditions. P to AP transitions are shown to occur by precession of the free layer magnetization, while the AP to P transition is typically direct, occurring in less than 200 ps. We associate the asymmetry with spin torques perpendicular to the plane of the free layer, an important characteristic of OST-MRAM bit cells that can be used to optimize device performance.
Kinetic modeling of 1,2‐dichloropropane (PDC) free‐radical chlorination (2016)

Recent government mandates have lowered the permissible global warming potential (GWP) for refrigerants in mobile air conditioning substantially below that of the hydrofluorocarbon products that are used currently. Potential replacements, hydrofluoro‐olefins (HFO), have a reduced impact on the ozone layer and lower GWP. Many desirable HFO compounds, such as HFO‐1234yf, can be produced utilizing chlorocarbons as feedstocks such as the preferred 1,1,2,3‐tetrachloropropene (TCPE). TCPE can be produced by several routes; however, producing TCPE from 1,2‐dichloropropane (PDC) is potentially more desirable environmentally and economically since PDC is a byproduct of propylene oxide and allyl chloride production. One process option is to convert PDC to pentachloropropane (PCP) intermediates by chlorination, followed by dehydrochlorination of the PCPs to produce TCPE. In this work, we show that PCPs can be produced through the chlorination of PDC in a free‐radical liquid phase reaction and have developed a kinetic model for PDC chlorination based on the relevant free radical elementary reactions. Thermodynamic properties including standard heats of formation, standard entropies of formation, and heat capacities for the radical and non‐radical species were estimated by using ab initio and COSMOtherm calculations and validated against available experimental data. The reaction equilibrium constants were determined from the Gibb's free energies of the reactants and products. Phase equilibria were calculated by means of a consistent set of thermodynamic properties of the species. In addition, physical properties such as the vapor pressure of pure components involved in the reaction network were also estimated. Ab initio transition state calculations were employed to estimate the rate parameters including pre‐exponential factors and activation energies for the relevant reactions. The activation energies of some key reactions were then adjusted to match experimental data. The resulting kinetic model provided a basis for process yield optimization and scale up. © 2016 American Institute of Chemical Engineers AIChE J , 62: 1174–1191, 2016
Attrition Resistant Iron-Based Fischer-Tropsch Catalysts (1997)

The Fischer-Tropsch (F-T) reaction provides a way of converting coal-derived synthesis gas (CO+H{sub 2}) to liquid fuels. Since the reaction is highly exothermic, one of the major problems in control of the reaction is heat removal. Recent work has shown that the use of slurry bubble column reactors (SBCRS) can largely solve this problem. Iron-based (Fe) catalysts are preferred catalysts for F-T when using low CO/H{sub 2} ratio synthesis gases derived from modem coal gasifiers. This is because in addition to reasonable F-T activity, the FT catalysts also possess high water gas shift (WGS) activity. However, a serious problem with the use of Fe catalysts in a SBCR is their tendency to undergo attrition. This can cause fouling/plugging of downstream filters and equipment, making the separation of catalyst from the oil/wax product very difficult if not impossible, and results in a steady loss of catalyst from the reactor. The objectives of this research are to develop a better understanding of the parameters affecting attrition resistance of Fe F-T catalysts suitable for use in SBCRs and to incorporate this understanding into the design of novel Fe catalysts having superior attrition resistance. Catalyst preparations will be based on the use of spray drying and will be scalable using commercially available equipment. The research will employ among other measurements, attrition testing and F-T synthesis, including long duration slurry reactor runs in order to ascertain the degree of success of the various preparations. The goal is to develop an Fe catalyst which can be used in a SBCR having only an internal filter for separation of the catalyst from the liquid product, without sacrificing F-T activity and selectivity.