gebhart/patrepeval huggingface dataset:
Dynamic Behavior of Cryogen Spray Cooling: Effect of Spray Distance (2003)

Cryogen spray cooling (CSC) is used to minimize the risk of epidermal damage during laser dermatologic surgery. During CSC, skin surface is cooled by a short spurt of refrigerant R134a with boiling point of −26.2°C. Since R134a is volatile in open atmospheric conditions, the atomized liquid droplets undergo continuous evaporation as they fly in air, leading to a lost momentum and mass. Therefore, the cooling effect of CSC depends strongly on the spray distance between the nozzle and the skin surface (L). The objective of this study was, therefore, to investigate the effect of L on the dynamic heat transfer of CSC. A skin model system made of poly methyl-methacrylate resin (Plexiglass®) is used to simulate CSC during laser dermatologic surgery. A fast-response temperature measurement sensor is built using thin (20 μm) aluminum foil and placed on top of the plexiglass with a 50 μm bead diameter thermocouple positioned in between. Variation of the surface temperature is then measured under various spray distances. The surface heat flux (q) as well as the heat transfer coefficient (h) between the surface and the cryogen is estimated by solving an inverse heat conduction problem with the measured temperature data as input. The effect of L on surface cooling in CSC is then investigated systematically. Both the estimated q and h show strong dynamic characteristics and are strong functions of the L. Two distinct spray-surface interaction mechanisms are identified within the spray distances studied. For short L (&lt; 30 mm), the spurt droplets impinge on the substrate violently, resulting in a fairly thin cryogen film deposited on the surface. Strong dynamics and high q result in this case, corresponding to a high h as well. Interestingly, h becomes strongly fluctuating and even larger after spurt termination for these cases. For long L (&gt; 30 mm), q is lower and it steadily decreases after spurt termination. The dynamic variation of h in this case is similar to that of q. These results should help in the selection of optimal CSC parameters, which are needed to produce high heat fluxes at the skin surface and thus obtain maximal epidermal protection during various dermatologic laser therapies.
The control method of 3-phase PWM converter for 3-phase 3-wired imbalanced AC voltages (2011)

In general, unbalanced 3-phase input voltage source in AC power system are inevitable since problems such as not only thunderbolt but also turning the switch on and off of the single phase load. In order to avoid such problems, conventional converters are provided with an uninterruptible power supply (UPS) or other additional storage devices such as capacitors and/or batteries. This paper describes that the 3-phase PWM converter with the compensated control can keep the rated output power stable by getting enough energy from the existing source of the phase voltages even if the unbalanced voltage happens to the 3-phase 3-wire AC system. There are some papers described about the control method of the PWM converter for 3-phase 4-wire system with unbalanced input voltages. However, there has been never the paper described for 3-phase 3-wire system. This paper is the new proposal to clear the problem on the PWM converter for 3-phase 3-wire AC system with unbalanced input voltages.
A novel insulin formulation with a more rapid onset of action (2008)

This study shows that the onset of action of VIAject is faster than that of human soluble insulin and insulin lispro.
New Approach to Color Variable Light-Emitting Devices Based on Conjugated Polymers. (1997)

Recently there have been reports on color variable light emitting devices. Here we present a new approach to such devices based on conjugated polymers. The device consists of a blend of pyridine-phenylene and thiophene-phenylene based copolymers sandwiched between two redox polymers: emeraldine base form of polyaniline and sulfonated polyaniline (SPAN). ITO and Al are used as electrodes. The devices work under either polarity of driving voltage with different colors of light being emitted from different locations, red from emitting polymer/SPAN interface under forward bias and green from bulk of the emitting polymers under reverse bias. Electroluminescence of the devices peak at 550 nm with a shoulder at 585 nm under reverse bias while they show a single peak at 665 nm under forward bias. The relative fast time response allows the rapid switch of colors and AC operation.
Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats (1997)

Glucagon-like peptide 2 (GLP-2) has recently been identified as a novel intestinal growth factor. Because experimental diabetes is associated with bowel growth, we examined the relationship between GLP-2 and intestinal growth in rats made diabetic by streptozotocin (STZ) injection and treated with or without insulin for 3 wk. Ileal concentrations of the intestinal proglucagon-derived peptides, i.e., glicentin + oxyntomodulin, and GLPs 1 and 2, were increased by 57 +/- 20% above those of controls in untreated STZ diabetes (P < 0.05-0.001). Similar increases in plasma concentrations of glicentin + oxyntomodulin (77 +/- 15% above controls, P < 0.01) and GLP-2 (91 +/- 32% above controls, P < 0.05) were seen in untreated STZ diabetes. Both wet and dry small intestinal weight increased by 74 +/- 20% above controls (P < 0.01) in STZ diabetes, and macromolecular analysis indicated parallel increases in both protein (P < 0.001) and lipid (P < 0.05) content. Villus height (P < 0.001) and crypt depth (P < 0.01) were also increased in untreated diabetic rat intestine. Insulin therapy prevented the changes in plasma GLP-2 and intestinal mass seen in untreated STZ diabetes. Thus STZ diabetes is associated with both increased production of GLP-2 and enhanced bowel weight, thereby suggesting a role for GLP-2 in diabetes-associated bowel growth.
A New Highly Versatile Handle for Chemistry on a Solid Support: The Pipecolic Linker (2010)

The design, synthesis, and potential application of the pipecolic linker is presented. This new versatile handle can immobilize primary, secondary, and aromatic amines, as well as alcohols, phenols, and hydrazides, on a solid support. Compared with other linkers, the anchoring step is easy and efficient. The release of final products from the resin proceeds upon acidic treatment with high purities. The pipecolic linker offers the promise of being using in peptide chemistry to produce peptides modified at the N and C terminus, peptidomimetics, as well as small organic molecules.
Molecular interferometric imaging study of molecular interactions (2008)

Molecular Interferometric Imaging (MI2) is a sensitive detection platform for direct optical detection of immobilized biomolecules. It is based on inline common-path interferometry combined with far-field optical imaging. The substrate is a simple thermal oxide on a silicon surface with a thickness at or near the quadrature condition that produces a π/2 phase shift between the normal-incident wave reflected from the top oxide surface and the bottom silicon surface. The presence of immobilized or bound biomolecules on the surface produces a relative phase shift that is converted to a far-field intensity shift and is imaged by a reflective microscope onto a CCD camera. Shearing interferometry is used to remove the spatial 1/f noise from the illumination to achieve shot-noise-limited detection of surface dipole density profiles. The lateral resolution of this technique is diffraction limited at 0.4 micron, and the best longitudinal resolution is 10 picometers. The minimum detectable mass at the metrology limit is 2 attogram, which is 8 antibody molecules of size 150 kDa. The corresponding scaling mass sensitivity is 5 fg/mm compared with 1 pg/mm for typical SPR sensitivity. We have applied MI2 to immunoassay applications, and real-time binding kinetics has been measured for antibody-antigen reactions. The simplicity of the substrate and optical read-out make MI2 a promising analytical assay tool for high-throughput screening and diagnostics.
A Nanoscaffold Impregnated With Human Wharton's Jelly Stem Cells or Its Secretions Improves Healing of Wounds (2013)

Wound healing is a major problem in diabetic patients and current methods of treatment have met with limited success. Since skin cell renewal is under the control of mesenchymal stem cells (MSCs) treatment of wounds has been attempted with the application of exogenous bone marrow MSCs (hBMMSCs). However, hBMMSCs have the limitations of painful harvest, low cell numbers and short-lived stemness properties unlike MSCs from the Wharton's jelly of human umbilical cords (hWJSCs). Since nanoscaffolds provide three dimensional architectural patterns that mimic in vivo stem cell niches and aloe vera has antibacterial properties we evaluated the use of an aloe vera-polycaprolactone (AV/PCL) nanoscaffold impregnated with green fluorescent protein (GFP)-labeled hWJSCs (GFP-hWJSCs + AV/PCL) or its conditioned medium (hWJSC-CM + AV/PCL) for healing of excisional and diabetic wounds. In skin fibroblast scratch-wound assays exposed to GFP-hWJSCs + AV/PCL or hWJSC-CM + AV/PCL, fibroblasts migrated significantly faster from edges of scratches into vacant areas together with increased secretion of collagen I and III, elastin, fibronectin, superoxide dismutase, and metalloproteinase-1 (MMP-1) compared to controls. After one application of GFP-hWJSCs + AV/PCL or hWJSC-CM + AV/PCL excisional and diabetic wounds in mice showed rapid wound closure, reepithelialization, and increased numbers of sebaceous glands and hair follicles compared to controls. The same wounds exposed to GFP-hWJSCs + AV/PCL or hWJSC-CM + AV/PCL also showed positive keratinocyte markers (cytokeratin, involucrin, filaggrin) and increased expression of ICAM-1, TIMP-1, and VEGF-A compared to controls. AV/PCL nanoscaffolds in combination with hWJSCs appear to have synergistic benefits for wound healing.
Reduction of NOx and Particulate Emissions by Using Oxygen-Enriched Combustion Air in a Locomotive Diesel Engine (2003)

This paper discusses operational and emissions results obtained with a locomotive (two-cylinder, EMD 567B) research diesel engine when oxygen-enriched combustion air is used. An operating regime was identified in which particulates and NOx could be reduced simultaneously when the concentration of intake air oxygen, fueling rate, and injection timing were optimized. Using oxygen from an external source, particulates were reduced by approximately 60% and NOx emissions were reduced by 15–20% with the optimal operating strategy. Higher gross power, lower peak cylinder pressures, and lower brake-specific fuel consumption were also observed. Gross power was increased by about 15–20% at base peak combustion pressure, and gross brake-specific fuel consumption was decreased by 2–10% with load. The effect of achieving oxygen enrichment by means of an air separation membrane is beyond the scope of the current study.
The Application of Dynamic Synapse Neural Networks on Footstep and Vehicle Recognition (2007)

In this paper we report application of biologically based dynamic synapse neural network (DSNN) on perimeter protection. More specifically, the purpose is to protect a fence line from approaching human being and vehicles. We have used geophones to detect seismic signals generated by footsteps and vehicles. While acoustic sensors can be fooled by artificial sounds, fooling geophones by artificial seismic waves is a complicated task. Moreover detecting human footsteps -weak signal to noise ratio -by acoustic waveform is subject to the distance between the sensor and human. Therefore detecting a human's footsteps by employing acoustic information will not be possible unless he/she walks close to the acoustic sensors. Geophones are resonant devices; therefore any vibration in the substrate can generate seismic waveforms which could be very similar to the signature generated by footstep or vehicle. In addition, geophone response is completely substrate dependent, rendering recognition of footsteps or vehicle vs. other vibrations to be a very difficult task. Therefore, in order to have robust and high-confidence classification/detection of a human/ vehicle threats, we have employed the DSNN. The network is trained to extract intrinsic characteristics of the waveform, frame by frame. Then parameters of the network are analyzed by Gaussian mixture models. The results of our study show 88.8% and 86% correct classification rate for the detection of human footsteps and vehicle respectively.
Investigation of Forward Voltage Uniformity in Monolithic Light-Emitting Diode Arrays (2013)

This letter reports the design and fabrication of optimized electrode structures for matrix addressable monolithic light-emitting diode arrays. The variation of forward voltages of LED pixels in the same row are greatly reduced from 2.62 V (81.9%) to 0.02 V (0.6%) in an 8×8 LED array. The LED arrays are designed with 8×8 square pixels, 500×500 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> with a 50-μm wide gap in between. A 24×24 large-scale blue LED panel is demonstrated with 0.06 V (1.8%) forward voltage variation by integrating nine LED array modules on a 2.2-cm diagonal silicon-based substrate. With a similar concept, a 30×30 green LED micro-display with scaled pixel pitch shows excellent display uniformity.
Malaria diagnosis using magnetic nanoparticles (2010)

The current gold standard method of Malaria diagnosis relies on the blood smears examination. The method is labor-intensive, time consuming and requires the expertise for data interpretation. In contrast, Raman scattering from a metabolic byproduct of the malaria parasite (Hemozoin) shows the possibility of rapid and objective diagnosis of malaria. However, hemozoin concentration is usually extremely low especially at the early stage of malaria infection, rendering weak Raman signal. In this work, we propose the sensitive detection of enriched β-hematin, whose spectroscopic properties are equivalent to hemozoin, based on surface enhanced Raman spectroscopy (SERS) by using magnetic nanoparticles. A few orders of magnitude enhancement in the Raman signal of β-hematin can be achieved using magnetic nanoparticles. Our result demonstrates the potential of SERS using magnetic nanoparticles in the effective detection of hemozoin for malaria diagnosis.
The major neutral proteinase of Entamoeba histolytica. (1986)

FPLC anion-exchange and chromatofocusing chromatography were used to purify the major neutral proteinase from secretions of axenically cultured Entamoeba histolytica trophozoites. HM-1 strain trophozoites, which were more proteolytically active than the less virulent HK-9 strain, were used for purification of the enzyme. It is a thiol proteinase with a subunit Mr of approximately 56,000, a neutral pH optimum, and a pI of 6. The importance of this enzyme in extraintestinal amoebiasis is suggested by its ability to degrade a model of connective tissue extracellular matrix as well as purified fibronectin, laminin, and type I collagen. The enzyme caused a loss of adhesion of mammalian cells in culture, probably because of its ability to degrade anchoring proteins. Experiments with a peptide substrate and inhibitors indicated that the proteinase preferentially binds peptides with arginine at P-1. It is also a plasminogen activator, and could thus potentiate host proteinase systems.
A framing strategy for congestion management (1991)

A congestion management strategy for integrated services packet networks that is robust with regard to transmission speed and network size is proposed. The strategy supports several classes of services with zero loss and different delay bounds as well as services without stringent loss and delay guarantees. Loss-free and bounded-delay transmission is accomplished by means of an admission policy which ensure smoothness of the traffic at the network edge, and by a service discipline called stop-and-go queuing, which maintains the traffic smoothness throughout the network. Both the admission policy and the stop-and-go queuing are based on a time framing concept described elsewhere by the author (IEEE Trans. Commun., vol.39, Dec.1991). This concept is further developed to incorporate several frame sizes into the strategy, thereby providing flexibility in meeting throughput and delay requirements of different applications. Stop-and-go queueing is realizable with minor modification to a first-in first-out (FIFO) queueing structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ultra High Efficiency Hybrid Direct Fuel Cell / Turbine Power Plant (2000)

FuelCell Energy, Inc has developed a design for a hybrid powerplant which combines the company’s carbonate Direct Fuel Cell (DFC) with a gas turbine cycle in an ultra high efficiency system. Under a recently completed program supported by the U.S. Department of Energy through the Federal Energy Technology Center (FETC, Morgantown WV), the system design was optimized to eliminate high-temperature developmental components and reduce the overall complexity of the cycle. Modeling studies indicate that the system is capable of operating with fuel-to-electrical LHV efficiencies in the low 70’s with near term fuel cell performance levels. Longer term fuel cell performance gains may provide system efficiencies near 80 percent.
The index-profile characterization of fiber preforms and drawn fibers (1980)

The information carrying capacity of multimode optical fibers is mainly determined by the quality of the refractive index distribution of their cores which, in turn, is determined by the distribution existing in the fiber's parent--the preform. This paper reviews methods that can be used to measure the index profiles of preforms--both multi-mode and single mode. Attention is also given to the effects of profile perturbations and means of eliminating them, as well as to applications of the techniques to fiber profiling.
Identification of Organic Colorants in Fibers, Paints, and Glazes by Surface Enhanced Raman Spectroscopy (2010)

Organic dyes extracted from plants, insects, and shellfish have been used for millennia in dyeing textiles and manufacturing colorants for painting. The economic push for dyes with high tinting strength, directly related to high extinction coefficients in the visible range, historically led to the selection of substances that could be used at low concentrations. But a desirable property for the colorist is a major problem for the analytical chemist; the identification of dyes in cultural heritage objects is extremely difficult. Techniques routinely used in the identification of inorganic pigments are generally not applicable to dyes: X-ray fluorescence because of the lack of an elemental signature, Raman spectroscopy because of the generally intense luminescence of dyes, and Fourier transform infrared spectroscopy because of the interference of binders and extenders. Traditionally, the identification of dyes has required relatively large samples (0.5-5 mm in diameter) for analysis by high-performance liquid chromatography. In this Account, we describe our efforts to develop practical approaches in identifying dyes in works of art from samples as small as 25 microm in diameter with surface-enhanced Raman scattering (SERS). In SERS, the Raman scattering signal is greatly enhanced when organic molecules with large delocalized electron systems are adsorbed on atomically rough metallic substrates; fluorescence is concomitantly quenched. Recent nanotechnological advances in preparing and manipulating metallic particles have afforded staggering enhancement factors of up to 10(14). SERS is thus an ideal technique for the analysis of dyes. Indeed, rhodamine 6G and crystal violet, two organic compounds used to demonstrate the sensitivity of SERS at the single-molecule level, were first synthesized as textile dyes in the second half of the 19th century. In this Account, we examine the practical application of SERS to cultural heritage studies, including the selection of appropriate substrates, the development of analytical protocols, and the building of SERS spectral databases. We also consider theoretical studies on dyes of artistic interest. Using SERS, we have successfully documented the earliest use of a madder lake pigment and the earliest occurrence of lac dye in European art. We have also found several examples of kermes and cochineal glazes, as well as madder, cochineal, methyl violet, and eosin lakes, from eras ranging from ancient Egypt to the 19th century. The ability to rapidly analyze very small samples with SERS makes it a particularly valuable tool in a museum context.
Generalized cross-signal anomaly detection on aircraft hydraulic system (2002)

This paper outlines the mathematical foundation for a general method of anomaly detection from time-correlated sensor data. This method is a component of BEAM, but as an individual algorithm is capable of fault detection and partial classification. The method is applicable to a broad class of problems and is designed to respond to any departure from normal operation, including faults or events that lie outside the training envelope. We will also consider training of the detector and interface to a larger diagnostic system. Lastly we examine a brief illustration taken from aircraft testing that demonstrates the power and versatility of this method.
Ionic Conductivity of Solid Electrolytes Based on Lithium Titanium Phosphate (1990)

Solid electrolytes based on lithium titanium phosphate were prepared, and their phase, porosity of the sintered pellets, and electrical conductivity were studied. The conductivity was increased and the porosity decreased greatly by partially replacing Ti4+ and P5+ in with M3+ and Si4+ions, respectively. The maximum conductivity at 298 K is for . The conductivity was considerably increased by the mixing of binders such as or with . The main reason for the conductivity enhancement of these electrolytes seems to be attributable to the increase of the sintered pellet density with the enhancement of the lithium concentration at the grain boundaries.
High-Pressure Transducer Package (1987)

Enclosure for silicon device ensures accurate measurements of cryogenic liquids. Package holds silicon sensor in uniform compression around periphery and helps ensure accurate, stable, and repeatable pressure measurements. Mounting assembly housed in package of stainless steel. Materials selected for equality of thermal expansion and for pressure-sealing properties. Besides its high-pressure, low-temperature characteristics, package withstands vibrations as severe as 400 times standard gravitational acceleration at 0 to 2,000 Hz.
Error resilient video coding for systems with delayed feedback (2012)

In systems employing feedback-based error resilience, error propagation can significantly degrade visual quality when feedback delay is in the order of a few seconds. We propose a coding structure based on multiple description coding that mitigates error propagation during feedback delay, and uses feedback to adapt its coding structure to effectively limit error propagation. We demonstrate the effectiveness of our approach at different error rates when compared to conventional coding schemes that use feedback.
Tri-modal spectroscopy as a tool for detecting cervical squamous intraeptihelial lesions in vivo (2001)

Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.