gebhart/patrepeval huggingface dataset:
Waveform synthesis for an electronic musical instrument (1981)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation George S. Klaiber, Anthony C. Ippolito, William R. Hoskinson; Waveform synthesis for an electronic musical instrument. J. Acoust. Soc. Am. 1 February 1981; 69 (2): 621. https://doi.org/10.1121/1.385387 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Advances in immune-modulating therapies to treat atherosclerotic cardiovascular diseases (2013)

In addition to hypercholesterolemia, innate and adaptive immune mechanisms play a critical role in atherogenesis, thus making immune-modulation therapy a potentially attractive way of managing atherosclerotic cardiovascular disease. These immune-modulation strategies include both active and passive immunization and confer beneficial reduction in atherosclerosis. Preclinical studies have demonstrated promising results and we review current knowledge on the complex role of the immune system and the potential for immunization as an immune-modulation therapy for atherosclerosis.
Development of Combinatorial Chemistry Methods for Coatings:  High-Throughput Screening of Abrasion Resistance of Coatings Libraries (2002)

Design, validation, and implementation of an optical spectroscopic system for high-throughput analysis of combinatorially developed protective organic coatings are reported. Our approach replaces labor-intensive coating evaluation steps with an automated system that rapidly analyzes 8 x 6 arrays of coating elements that are discretely deposited on a single plastic substrate. Each coating element of the library is 10 mm in diameter and 2-5 microm thick. Performance of coatings is evaluated with respect to their resistance to wear abrasion because this parameter is one of the primary considerations in end-use applications. Upon testing, the coating materials undergo changes that are impossible to quantitatively predict using existing knowledge. Coatings are abraded using industry-accepted abrasion test methods at a single or multiple abrasion conditions followed by the high-throughput analysis of abrasion-induced light scatter. The developed automated system is optimized for the analysis of diffusively scattered light that corresponds to 0-30% haze. System precision of 0.1-2.5% relative standard deviation provides capability for the reliable ranking of coatings performance. Although the system was implemented for high-throughput screening of combinatorially developed organic protective coatings for automotive applications, it can be applied for a variety of other applications for which materials ranking can be achieved using optical spectroscopic tools.
RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 DELIVERED IN AN INJECTABLE CALCIUM PHOSPHATE PASTE ACCELERATES OSTEOTOMY-SITE HEALING IN A NONHUMAN PRIMATE MODEL (2004)

A single percutaneous injection of rhBMP-2/alpha-BSM accelerates the healing of fibular osteotomy sites in nonhuman primates by approximately 40% compared with the healing of untreated osteotomy sites.
Feasibility study of rare earth semiconductor lasers of the type Y/sub 2/HfS/sub 5/. Technical report (1977)

The possibility of making a rare earth or rare earth doped semiconductor laser was investigated. The material examined in detail was Y/sub 2/HfS/sub 5/, which is of the general class of materials Ln/sub 2/TX/sub 5/, where Ln is a rare earth, T is zirconuim or hafnium, and X is sulfur or selenium. For Y/sub 2/HfS/sub 5/;Nd, the Stark split energy levels of Nd(3+) were determined in the energy range 0 to 2 eV (the band gap of Y/sub 2/HfS/sub 5/). The individual line to line transition probabilities were calculated assuming S4 symmetry for the Nd (3+) site, and the branching ratios are given. The calculated branching ratio for spontaneous emission of the 4F (3/2) to the 4I (1/2) is 0.574, and the next largest branching ratio of the 4F (3/2) to 4I (9/2) is 0.298. The branching ratio for the 4I (1/2) is larger in this material than the calculated branching ratio for Nd in YAG, which is 0.480. The transition probabilities are used to calculate the excitation of the various multiplets by conduction electrons.
Nonlinear optical correlator (1988)

A nonlinear joint transform image correlator is investigated. The Fourier transform interference intensity is thresholded to provide higher correlation peak intensity and a better defined correlation spot. Analytical expressions for the thresholded interference intensity are provided. The effects of nonlinearity at the Fourier plane on the correlation spots at the output plane are investigated. The correlation signals are determined in terms of the nonlinear characteristics of the spatial light modulator at the Fourier plane. We show that thresholding interference intensity results in a sum of infinite harmonic terms. Each harmonic is envelope modulated due to the nonlinear characteristics of the devices and phase modulated by m times the phase modulation of the nonthresholded interference intensity. The correct phase information about the correlation signal is recovered from the first-order harmonic of the thresholded interference intensity.
Improved Syntheses of the NaturallyOccurring Glycosidase Inhibitor Salacinol (2003)

Improved syntheses of the naturally occurring sulfonium ion, salacinol are described. Salacinol is one of the active principles in the aqueous extracts of Salacia reticulata that are traditionally used in Sri Lanka and India for the treatment of Type 2 Diabetes. The synthetic strategy relies on the nucleophilic attack of 2,3,5-tri-O-benzyl- or 2,3,5-tri-O-p-methoxybenzyl-1,4-anhydro-4-thio-d-arabinitol at the least hindered carbon of benzylidene-protected l-erythritol-1,3-cyclic sulfate in 1,1,1,3,3,3-hexafluoro-2-propanol as solvent. The reactions are compared to those with the benzyl-protected l-erythritol-1,3-cyclic sulfate and also to those in acetone and 2-propanol. Excellent yields are obtained for the reactions with the benzylidene-protected cyclic sulfate. The synthetic route employing p-methoxybenzyl ether protecting groups is advantageous since all protecting groups in the adduct may be removed with tri­fluoroacetic acid to yield salacinol, thereby obviating the problematic deprotection of benzyl ethers by hydrogenolysis.
High current transmission line pulse (TLP) and ESD characterization of a silicon germanium heterojunction bipolar transistor with carbon incorporation (2003)

Electrostatic discharge robustness of an epitaxial-base pseudomorphic Silicon Germanium Heterojunction Bipolar Transistor (HBT) device with Carbon incorporation is shown for the first time. Experimental results show that incorporation of Carbon in the base of a SiGe HBT device improves power-to-failure variation by improved control of the base width and base width distribution.
Hadamard-Encoded Multipulses for Contrast-Enhanced Ultrasound Imaging (2017)

The development of contrast-enhanced ultrasound (CEUS) imaging offers great opportunities for new ultrasound clinical applications such as myocardial perfusion imaging and abdominal lesion characterization. In CEUS imaging, the contrast agents (i.e., microbubbles) are utilized to improve the contrast between blood and tissue based on their high nonlinearity under low ultrasound pressure. In this paper, we propose a new CEUS pulse sequence by combining Hadamard-encoded multipulses (HEM) with fundamental frequency bandpass filter (i.e., filter centered on transmit frequency). HEM consecutively emits multipulses encoded by a second-order Hadamard matrix in each of the two transmission events (i.e., pulse-echo events), as opposed to conventional CEUS methods which emit individual pulses in two separate transmission events (i.e., pulse inversion (PI), amplitude modulation (AM), and PIAM). In HEM imaging, the microbubble responses can be improved by the longer transmit pulse, and the tissue harmonics can be suppressed by the fundamental frequency filter, leading to significantly improved contrast-to-tissue ratio (CTR) and signal-to-noise ratio (SNR). In addition, the fast polarity change between consecutive coded pulse emissions excites strong nonlinear microbubble echoes, further enhancing the CEUS image quality. The spatial resolution of HEM image is compromised as compared to other microbubble imaging methods due to the longer transmit pulses and the lower imaging frequency (i.e., fundamental frequency). However, the resolution loss was shown to be negligible and could be offset by the significantly enhanced CTR, SNR, and penetration depth. These properties of HEM can potentially facilitate robust CEUS imaging for many clinical applications, especially for deep abdominal organs and heart.
Automatic characterization of sleep need dissipation dynamics using a single EEG signal (2015)

In the two-process model of sleep regulation, slow-wave activity (SWA, i.e. the EEG power in the 0.5-4 Hz frequency band) is considered a direct indicator of sleep need. SWA builds up during non-rapid eye movement (NREM) sleep, declines before the onset of rapid-eye-movement (REM) sleep, remains low during REM and the level of increase in successive NREM episodes gets progressively lower. Sleep need dissipates with a speed that is proportional to SWA and can be characterized in terms of the initial sleep need, and the decay rate. The goal in this paper is to automatically characterize sleep need from a single EEG signal acquired at a frontal location. To achieve this, a highly specific and reasonably sensitive NREM detection algorithm is proposed that leverages the concept of a single-class Kernel-based classifier. Using automatic NREM detection, we propose a method to estimate the decay rate and the initial sleep need. This method was tested on experimental data from 8 subjects who recorded EEG during three nights at home. We found that on average the estimates of the decay rate and the initial sleep need have higher values when automatic NREM detection was used as compared to manual NREM annotation. However, the average variability of these estimates across multiple nights of the same subject was lower when the automatic NREM detection classifier was used. While this method slightly over estimates the sleep need parameters, the reduced variability across subjects makes it more effective for within subject statistical comparisons of a given sleep intervention.
Co-administered Tag-Less Toxoid Fusion 3xSTaN12S-mnLTR192G/L211A and CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) Induce Neutralizing Antibodies to 7 Adhesins (CFA/I, CS1-CS6) and Both Enterotoxins (LT, STa) of Enterotoxigenic Escherichia coli (ETEC) (2018)

Enterotoxigenic <i>Escherichia coli</i> (ETEC) bacteria remain a leading cause of children's diarrhea and travelers' diarrhea. Vaccines that induce antibodies to block ETEC bacterial adherence and to neutralize toxin enterotoxicity can be effective against ETEC-associated diarrhea. Recent studies showed that 6xHis-tagged CFA/I/II/IV multiepitope fusion antigen (MEFA) induced broad-spectrum antibodies to inhibit adherence of the seven most important ETEC adhesins (CFA/I, CS1 to CS6) (Ruan et al., 2014a) and 6xHis-tagged toxoid fusion antigen 3xSTa<sub>N12S</sub>-mnLT<sub>R192G/L211A</sub> (previously named as 3xSTa<sub>N12S</sub>-dmLT) elicited antibodies to neutralize both heat-labile toxin (LT) and heat-stable toxin (STa) produced by ETEC strains (Ruan et al., 2014b). In this study, we constructed two new genes to express tag-less toxoid fusion 3xSTa<sub>N12S</sub>-mnLT<sub>R192G/L211A</sub> and tag-less CFA/I/II/IV MEFA and then examined immunogenicity of each tag-less protein in mouse immunization. We further combined two tag-less proteins and investigated antigen co-administration in mice. Data showed that mice immunized with tag-less 3xSTa<sub>N12S</sub>-mnLT<sub>R192G/L211A</sub> or tag-less CFA/I/II/IV MEFA developed antigen-specific IgG antibody responses, and mice co-administered with two tag-less proteins induced neutralizing antibodies against seven adhesins and both toxins. These results indicated tag-less toxoid fusion 3xSTa<sub>N12S</sub>-mnLT<sub>R192G/L211A</sub> and tag-less CFA/I/II/IV MEFA administered individually or combined induced neutralizing antitoxin and/or anti-adhesin antibodies, and suggested the potential application of two tag-less proteins for ETEC vaccine development.
Circuit design approach for high extinction integrated optic modulators and switches (1989)

A circuit design approach using cascaded structures for integrated optic modulators and switches with high extinction ratios is described and analyzed. The extinction ratios are improved by a multiplication effect and can be exceeding 30 dB for polarization independent devices with no individual voltage tuning. The trade-offs are more chip area consumption, more optical insertion loss, and a slower device response speed. These trade-offs can be minor for nonhigh speed applications, such as photonic cross-connect systems, where the switch control and crosstalk are more important issues.
High-Speed Correlation and Equalization Using a Continuously Tunable All-Optical Tapped Delay Line (2012)

We demonstrate a reconfigurable high-speed optical tapped delay line (TDL), enabling several fundamental real-time signal processing functions such as correlation (for pattern search) and equalization. Weighted taps are created and added using optical multicasting and multiplexing schemes that utilize the nonlinear wave mixings in the periodically poled lithium niobate (PPLN) waveguides. Tunable tap delays are realized using the conversion-dispersion technique. In the demonstrated TDL, the amplitude and phase of tap coefficients can be varied, enabling signal processing on amplitude- and phase-encoded optical signals. We experimentally demonstrate the tunability of the TDL in time, amplitude, and phase. We analyze the TDL's theory of operation and present experimental results on reconfigurable pattern search (correlation) on on-off-keyed and phase-shift-keyed signals at data rates of up to 80 Gb/s, as well as equalization for chromatic dispersion.
The effect of diamic acid additives on the dielectric constant of polyimides (1988)

The effect of six selected diamic acids additives (including 2,2-prime bis(3,4-dicarboxyphenyl) hexafluoropropane dianhydride-aniline (An); 4,4-prime-oxydiphthalic anhydride-An, 3,3-prime diaminodiphenyl sulfone-phthalic anhydride (PA); 4,4-prime-oxydianiline-PA; 2,2-bis 4(4-aminophenoxy)phenyl hexafluoropropane-PA; and 2,2-bis 4(3-aminophenoxy)phenyl hexafluoropropane-PA) on the dielectric constants of low-dielectric-constant polyimide resins was evaluated. It was found that the effect of the incorporation of the diamic acids on reducing the dielectric constant of polyimides may be limited as the dielectric constant of the base resin itself becomes very low. The additives were found to lower the resin's values of glass transition temperature, with no effect on thermooxidative stability.
Structure−Activity Relationships at Monoamine Transporters and Muscarinic Receptors for <i>N</i>-Substituted-3α-(3‘-chloro-, 4‘-chloro-, and 4‘,4‘ ‘-dichloro-substituted-diphenyl)methoxytropanes (2001)

The design, synthesis, and evaluation of 3alpha-(diphenylmethoxy)tropane (benztropine) analogues have provided potent and selective probes for the dopamine transporter. Structure-activity relationships (SARs) have been developed that contrast with those described for cocaine, despite significant structural similarity. Furthermore, behavioral evaluation of many of the benztropine analogues in animal models of cocaine abuse has suggested that these two classes of tropane-based dopamine uptake inhibitors have distinct pharmacological profiles. In general, the benztropine analogues do not demonstrate efficacious locomotor stimulation in mice, do not fully substitute for a cocaine discriminative stimulus, and are not appreciably self-administered in rhesus monkeys. These compounds are generally more potent than cocaine as dopamine uptake inhibitors in vitro, although their actions in vivo are not consistent with this action. These observations suggest that differing binding profiles at the serotonin and norepinephrine transporters as well as at muscarinic receptors might have significant impact on the pharmacological actions of these compounds. In addition, by varying the structures of the parent compounds and thereby modifying their physical properties, pharmacokinetics as well as pharmacodynamics will be directly affected. Therefore, in an attempt to systematically evaluate the impact of chemical modification on these actions, a series of N-substituted (H, CH3, allyl, benzyl, propylphenyl, and butylphenyl) analogues of 3'-chloro-, 4'-chloro-, and 4,4''-dichloro-3alpha-(diphenylmethoxy)tropanes were synthesized. These compounds were evaluated for displacement, in rat tissue, of [3H]WIN 35,428 from the dopamine transporter, [3H]citalopram from the serotonin transporter, [3H]nisoxetine from the norepinephrine transporter, and [3H]pirenzepine from muscarinic m1 receptors. SARs were developed and compared to a series of N-substituted-3alpha-(bis-4'-fluorophenyl)methoxytropanes. The present SARs followed previously reported studies with the single exception of the N-butylphenyl substituent, which did not provide the high affinity binding in any of these three sets of analogues, as it did in the 4',4''-difluoro series. X-ray crystallographic analyses of the three parent ligands (1a, 2a, and 3a) were compared to that of 3alpha-(bis-4'-fluorophenyl)methoxytropane which provided supportive evidence toward the proposal that the combination of steric bulk in both the 3-position and the N-substituent, in this class of compounds, is not optimal for binding at the dopamine transporter. These studies provide binding profile data that can now be used to correlate with future behavioral analyses of these compounds and may provide insight into the kind of binding profile that might be targeted as a potential treatment for cocaine abuse.
Scalable Face Image Retrieval with Identity-Based Quantization and Multireference Reranking (2011)

State-of-the-art image retrieval systems achieve scalability by using a bag-of-words representation and textual retrieval methods, but their performance degrades quickly in the face image domain, mainly because they produce visual words with low discriminative power for face images and ignore the special properties of faces. The leading features for face recognition can achieve good retrieval performance, but these features are not suitable for inverted indexing as they are high-dimensional and global and thus not scalable in either computational or storage cost. In this paper, we aim to build a scalable face image retrieval system. For this purpose, we develop a new scalable face representation using both local and global features. In the indexing stage, we exploit special properties of faces to design new component-based local features, which are subsequently quantized into visual words using a novel identity-based quantization scheme. We also use a very small Hamming signature (40 bytes) to encode the discriminative global feature for each face. In the retrieval stage, candidate images are first retrieved from the inverted index of visual words. We then use a new multireference distance to rerank the candidate images using the Hamming signature. On a one millon face database, we show that our local features and global Hamming signatures are complementary--the inverted index based on local features provides candidate images with good recall, while the multireference reranking with global Hamming signature leads to good precision. As a result, our system is not only scalable but also outperforms the linear scan retrieval system using the state-of-the-art face recognition feature in term of the quality.
The dopamine D2 receptor gene and alcoholism. (1991)

To the Editor.— Bolos et al, 1 in contrast to us, 2 purport to find a lack of association between the dopamine D 2 receptor (D 2 R) gene and alcoholism. In the selection of 40 alcoholic subjects, Bolos et al used as exclusion criterion an acutely active medical disorder as revealed by the patient's medical history, physical examination, or clinical laboratory assessment. By systematically excluding severely ill alcoholics (or presumably even alcoholics with minor abnormalities in clinical chemistry), these investigators studied a quite different and less severely ill alcoholic population than we did. Our study consisted of alcoholics who had experienced repeated failures in their alcoholic rehabilitation and whose cause of death was primarily attributed to alcohol-induced damage to their bodily systems. We used a sample of 35 alcoholics and 35 nonalcoholic controls, and the two groups were matched on age and other important variables. Bolos et al
High temperature polymers. III. Diphenyl sulfone‐based polyamide‐imides (1974)

Abstract High temperature thermoplastic polyamide‐imides were prepared from a new series of aromatic diamines containing the diphenylsulfone unit and alternatively, oxydiphenyl and diphenylisopropylidene units. The polymers were prepared in their completely imidized form by using a facile in situ chemical imidization reaction which offers several advantages over the conventional thermal imidization process. The sulfone‐based polyamide‐imides exhibited an excellent combination of moldability, thermal stability, mechanical properties and solvent resistance. Analysis of the properties of these polymers in terms of structural variations permits a useful correlation of the effect of various structural units on performance. The polar diphenyl sulfone and amide‐imide units increase the glass transition temperature and improve solvent resistance while the oxydiphenyl and diphenylisopropylidene units improve thermoplasticity. Sulfone ether diamine polyamide‐imide (VI) offers the best combination of high temperature performance and moldability.
Designing brighter near-infrared fluorescent proteins: insights from structural and biochemical studies (2017)

Brighter near-infrared (NIR) fluorescent proteins (FPs) are required for multicolor microscopy and deep-tissue imaging. Here, we present structural and biochemical analyses of three monomeric, spectrally distinct phytochrome-based NIR FPs, termed miRFPs. The miRFPs are closely related and differ by only a few amino acids, which define their molecular brightness, brightness in mammalian cells, and spectral properties. We have identified the residues responsible for the spectral red-shift, revealed a new chromophore bound simultaneously to two cysteine residues in the PAS and GAF domains in blue-shifted NIR FPs, and uncovered the importance of amino acid residues in the N-terminus of NIR FPs for their molecular and cellular brightness. The novel chromophore covalently links the N-terminus of NIR FPs with their C-terminal GAF domain, forming a topologically closed knot in the structure, and also contributes to the increased brightness. Based on our studies, we suggest a strategy to develop spectrally distinct NIR FPs with enhanced brightness.