gebhart/patrepeval huggingface dataset:
An effective approach for large scale floorplanning (2010)

Floorplacement" has attracted attention, as a placement formula- tion for designs with thousands or millions of soft macro blocks. In this paper, we investigate the "standard block" approach, where soft blocks are shaped to have uniform height, rather than a wide range of different sizes. This allows many macro blocks can be treated as standard cells, simplifying the problem to one of ordinary mixed size placement. We obtain high quality results for a suite of recent benchmarks, and also present novel legalization algorithms that are more robust than the widely-used mixed-size tetris approach.
OCT of early dental caries: a comparative study with histology and Raman spectroscopy (2005)

Early dental caries result from destruction of the tooth's outer mineral matrix by acid-forming bacteria found in dental plaques. Early caries begin as surface disruptions where minerals are leached from the teeth resulting in regions of decreased mineral matrix integrity. Visually, these early carious regions appear as white spots due to the higher backscattering of incident light. With age these areas may become stained by organic compounds. Optical coherence tomography (OCT) examination of human teeth demonstrates a difference in penetration depth of the OCT signal into the carious region in comparison with sound enamel. However, while OCT demonstrates a structural difference in the enamel in the region of the caries, this technique provides little insight into the source of this difference. Raman spectroscopy provides biochemical measures derived from hydroxyapatite within the enamel as well as information on the crystallinity of the enamel matrix. The differences in the biochemical and morphological features of early caries and intact sound enamel are compared. Histological thin sections confirm the observations by OCT morphological imaging while Raman spectroscopy allows for biochemical identification of carious regions by a non-destructive method. Visual examination and conventional radiographic imaging of the intact tooth are used in clinical assessment prior to optical measurements. The combination of OCT, Raman spectroscopy and thin section histology aid in determining the changes that give rise to the visual white spot lesions.
The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer (2014)

From a basic science standpoint, future directions in the field include the delineation of the molecular mechanism of CBS up-regulation of cancer cells and the delineation of the interactions of H2S with other intracellular pathways of cancer cell metabolism and proliferation. From the translational science standpoint, future directions include the translation of the recently emerging roles of H2S in cancer into human diagnostic and therapeutic approaches.
<scp>SK</scp> 4 K <sup>+</sup> channels are therapeutic targets for the treatment of cardiac arrhythmias (2017)

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-provoked ventricular arrhythmia, which also manifests sinoatrial node (SAN) dysfunction. We recently showed that SK4 calcium-activated potassium channels are important for automaticity of cardiomyocytes derived from human embryonic stem cells. Here SK4 channels were identified in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from healthy and CPVT2 patients bearing a mutation in calsequestrin 2 (CASQ2-D307H) and in SAN cells from WT and CASQ2-D307H knock-in (KI) mice. TRAM-34, a selective blocker of SK4 channels, prominently reduced delayed afterdepolarizations and arrhythmic Ca<sup>2+</sup> transients observed following application of the β-adrenergic agonist isoproterenol in CPVT2-derived hiPSC-CMs and in SAN cells from KI mice. Strikingly, <i>in vivo</i> ECG recording showed that intraperitoneal injection of the SK4 channel blockers, TRAM-34 or clotrimazole, greatly reduced the arrhythmic features of CASQ2-D307H KI and CASQ2 knockout mice at rest and following exercise. This work demonstrates the critical role of SK4 Ca<sup>2+</sup>-activated K<sup>+</sup> channels in adult pacemaker function, making them promising therapeutic targets for the treatment of cardiac ventricular arrhythmias such as CPVT.
Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP (1984)

Chronic idiopathic thrombocytopenic purpura (ITP) is caused by an antibody reactive with platelet-associated antigens. The present studies provide direct evidence that some patients with chronic ITP have autoantibodies against the platelet glycoprotein (GP) IIb/IIIa complex. Microtiter wells, coated with a monoclonal antibody (2G12) specific for GPIIb/GPIIIa were reacted with GPIIb/GPIIIa contained in a platelet extract. Control wells containing the same antibody were reacted with a cell extract containing no GPIIb/GPIIIa. After washing, the wells were reacted with patient or control plasma, and IgG binding was detected using 125I-Fab2-anti-human IgG. Assay values were expressed as binding ratios (cpm GPIIb/GPIIIa wells/cpm control wells). Plasma from 5 of 56 patients with chronic ITP had ratios (1.36-3.14) greater than 3 standard deviations above the mean (+/- SD) of control plasmas--0.93 +/- 0.12. Elevated values were also noted in two patients with anti-P1A1 antibody (ratios greater than 30) and in one patient with Hodgkin's disease and an ITP-like syndrome (ratio 1.53). Normal values were noted in 34 patients with a variety of immune and nonimmune diseases. Plasma from two of the positive ITP patients was reacted with 125I-surface-labeled platelets and, after solubilization, the IgG and bound antigen were precipitated with Staph-A. Autoradiographs from SDS-PAGE electrophoresis of the Staph-A-bound proteins shows two radioactive bands consistent in size with GPIIb and GPIIIa.
Design and Analysis of Compressive Data Persistence in Large-Scale Wireless Sensor Networks (2014)

This paper addresses the data persistence problem in wireless sensor networks (WSNs) where static sinks are not present and the sensed data have to be temporarily but resiliently stored in the network. Based on the observation that sensor readings are correlated, we propose compressive data persistence (CDP) scheme that makes use of the compressive sensing (CS) theory. Each sensor node independently computes and stores a random projection of the sensed data, such that a mobile sink can recover the data with high probability after visiting a small and random portion of the network. As a prerequisite of distributed CS encoding, sensor readings from all nodes are disseminated within the network through random walk. Therefore, the CS measurement matrix depends heavily on how the random walk is performed. In this paper, we present an in-depth analysis on the interplay between random walk parameters and sensing data characteristics, and derive the conditions in successful CS data recovery. In addition, we discover that there is a trade-off between the number of random walk instances and steps in order to achieve the required data persistence performance. Experiments using real sensor data verify that the proposed CDP scheme achieves much lower decoding ratio than the state-of-the-art Fountain code based schemes or the decentralized erasure codes based schemes, and demonstrate that there exist energy-optimized random walk parameters for CDP.
A sub-millimeterwave micromachined frequency beam-steering antenna array (2014)

This paper describes a novel travelling-wave frequency beam-scanning array antenna operating at Y-band. The proposed antenna is composed of over 40 cavity-backed patch arrays as the radiating elements, with a total of 588 patch elements. The array generates a very narrow beam (HPBW of less than 2.5°) at the broadside of the antenna with ±25° steering capability. A prototype of the proposed antenna is fabricated using silicon micromachining with high level of accuracy and low mass and cost. To characterize the micromachined antenna, a novel waveguide-probe near-field measurement setup is proposed and good agreement between the measurement and the full-wave simulation results of the antenna is shown.
ChemInform Abstract: A NOVEL REARRANGEMENT OF 3‐CYANOPYRAZOLO(1,5‐A)PYRIMIDINE TO A PYRAZOLO(3,4‐D)PYRIMIDINE (1974)

Abstract 3‐Cyan‐5,7‐dimethyl‐pyrazolo(1,S‐a)pyrimidin (I) liefert mit alkalischem Wasserstoff peroxid über (II) das Umlagerungsprodukt (III), das auch aus (IV) hergestellt werden kann.
The World Conversation (2015)

Over the past couple of years, social networks such as Twitter and Facebook have become the primary source for consuming information on the Internet. One of the main differentiators of this content from traditional information sources available on the Web is the fact that these social networks surface individuals' perspectives. When social media users post and share updates with friends and followers, some of those short fragments of text contain a link and a personal comment about the web page, image or video. We are interested in mining the text around those links for a better understanding of what people are saying about the object they are referring to. Capturing the salient keywords from the crowd is rich metadata that we can use to augment a web page. This metadata can be used for many applications like ranking signals, query augmentation, indexing, and for organizing and categorizing content. In this paper, we present a technique called social signatures that given a link to a web page, pulls the most important keywords from the social chatter around it. That is, a high level representation of the web page from a social media perspective. Our findings indicate that the content of social signatures differs compared to those from a web page and therefore provides new insights. This difference is more prominent as the number of link shares increase. To showcase our work, we present the results of processing a dataset that contains around 1 Billion unique URLs shared in Twitter and Facebook over a two month period. We also provide data points that shed some light on the dynamics of content sharing in social media.
Electron{plasmonresonanceinquantumwellswithinverted subbandpopulation (2000)

The inverted order of subband occupation,n2>n1, in quantum-well heterostructures designed for the intersubband lasers results in a novel eective relaxation mechanism for nonequilibrium electrons in the lower subband due to emission of the intersubband plasmons. In contrast to the cascade relaxation by phonons and intrasubband plasmons, this one-step scattering process eciently lls the nal states for light-emitting transitions. Resonant screening, which is inuenced by the process of intersubband plasmon excitation, leads to downshift and narrowing of the intersubband optical emission spectra. ? 2000 Elsevier Science B.V. All rights reserved.
Tetrahydrofuran‐Soluble Magnesium Dihydride by Catalytic Hydrogenation of Magnesium<sup>*)</sup> (1991)

Upon hydrogenation of magnesium in THF using homogeneous magnesium‐anthracene transition‐metal halide catalysts in the presence of small amounts of MgCl 2 and solubilizing agents L, a dissolved form of magnesium hydride (MgH' 2 ) is produced. The preferred L's are quinuclidine (QC) or organomagnesium compounds; however, organoaluminium and ‐boron compounds can also be used. The fraction n of magnesium hydride produced in the dissolved form and the stability of the MgH' 2 solutions are investigated as a function of the kind and the amount of solubilizing agents and catalysts. The optimized method for the preparation of MgH' 2 is described. The magnesium hydride dissolved in THF is characterized by IR spectroscopy. In order to elucidate the role of the solubilizing agents, THF‐soluble MgCl 2 ‐containing stoichiometric MgH 2 · QC model complexes are also prepared and characterized by IR spectra. Advantages and disadvantages of using MgH' 2 for synthetic purposes instead of catalytically prepared suspensions of magnesium hydride (MgH 2 ) are discussed.
A Simple Quality Assessment Index for Stereoscopic Images Based on 3D Gradient Magnitude (2014)

We present a simple quality assessment index for stereoscopic images based on 3D gradient magnitude. To be more specific, we construct 3D volume from the stereoscopic images across different disparity spaces and calculate pointwise 3D gradient magnitude similarity (3D-GMS) along three horizontal, vertical, and viewpoint directions. Then, the quality score is obtained by averaging the 3D-GMS scores of all points in the 3D volume. Experimental results on four publicly available 3D image quality assessment databases demonstrate that, in comparison with the most related existing methods, the devised algorithm achieves high consistency alignment with subjective assessment.
Angular dependence of optical scattering in mixed nematic-cholesteric liquid crystals (1973)

Although the wavelength of maximum scattering in cholesteric liquid crystals is strongly angularly dependent, doping with nematics can produce systems in which the angular distortion is considerably reduced, thus making color display applications much more feasible.
Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophore (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophoreDale L. Boger, Takayoshi Ishizaki, Hamideh Zarrinmayeh, P. A. Kitos, and O. SuntornwatCite this: J. Org. Chem. 1990, 55, 15, 4499–4502Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/jo00302a002https://doi.org/10.1021/jo00302a002research-articleACS PublicationsRequest reuse permissionsArticle Views329Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Recent launches using the SoftRide whole-spacecraft vibration isolation system (2001)

Passive whole-spacecraft vibration isolation systems have been developed for launch vehicles to greatly reduce the dynamic launch loads. To date, three types of isolation systems have been designed, and two types have been flown. The first is a single-axis axial isolation system (SoftRide UniFlex) that provides isolation for predominantly axial loads. This type of system has been flown successfully three times on the Taurus/GFO mission in February 1998, the Taurus/STEX mission in October 1998, and the Taurus/MTI mission in March 2000. The second type of isolation system is a multi-axis device that provides vibration isolation in three axes. This type of system is needed to alleviate dynamic launch loads on the Minotaur vehicle. This multi-axis system inserts flexibility and damping in three orthogonal axes between the launch vehicle and the satellite. The result is that dynamic launch loads with both axial and lateral components can be effectively mitigated. The multi-axis isolation (SoftRide Multiplex) system is a logical extension of the single-axis system and has the same qualities of being simple, passive, small, lightweight, reliable, and highly effective. Two flights have demonstrated the SoftRide Multiplex isolation system to date: these are the Minotaur/JAWSAT mission in January of 2000 and the Minotaur/MightySat mission in July 2000. Coupled loads analyses and flight telemetry data indicate that both the patented UniFlex and Multiplex isolation systems have provided a softer ride to orbit for satellites on small launch vehicles. Additionally, these isolation systems provide extreme reductions to shock and structure-borne acoustic loads.
Recommending tumblr blogs to follow with inductive matrix completion (2014)

In microblogging sites, recommending blogs (users) to follow is one of the core tasks for enhancing user experience. In this paper, we propose a novel inductive matrix completion based blog recommendation method to effectively utilize multiple rich sources of evidence such as the social network and the content as well as the activity data from users and blogs. Experiments on a large-scale real-world dataset from Tumblr show the effectiveness of the proposed blog recommendation method.
Testing the Impact of Personalized Feedback on Household Travel Behavior (TRAC-IT 2) (2008)

When presented with their household's travel patterns and practical ways to improve their trip planning or even eliminate trips, more travelers could find new opportunities to use transit, bicycling or walking, and do less solo driving. This three-phase study harnessed the exponential growth of personal mobile electronic devices integrated with increasingly accurate global positioning systems to develop a non-proprietary location aware information system (TRAC-IT). The conceptual phase used a personal digital assistant equipped with GPS and developed a rule-based expert system to collect travel data and generate travel suggestions. The second phase created a Personal Travel Coach consisting of an enhanced rule-based expert system and a real-time path prediction prototype. The third phase resulted in the first non-proprietary, intelligent software system on GPS-enabled mobile phones to successfully track person movements across all modes and also developed innovative analysis techniques such as purpose and mode detection algorithms. Path prediction allows TRAC-IT to detect potential incidents within the user's probable travel route and provide real-time travel advice to the traveler before they reach the problem areas. The TRAC-IT system should advance the quality and quantity of household multimodal data collected in travel surveys. The TRAC-IT application's Personal Travel Coach components; the Expert System and Path Prediction Prototype, give transportation professionals the next-generation location aware information system they need to understand, plan, and influence travel behavior. Technical and policybased challenges, inherent with such innovative research, are also discussed. 17.
Prevention of egg contamination by Salmonella Enteritidis after oral vaccination of laying hens with Salmonella Enteritidis ΔtolC and ΔacrABacrEFmdtABC mutants (2016)

Vaccination of laying hens has been successfully used to reduce egg contamination by Salmonella Enteritidis, decreasing human salmonellosis cases worldwide. Currently used vaccines for layers are either inactivated vaccines or live attenuated strains produced by mutagenesis. Targeted gene deletion mutants hold promise for future vaccines, because specific bacterial functions can be removed that may improve safety and allow differentiation from field strains. In this study, the efficacy of Salmonella Enteritidis ΔtolC and ΔacrABacrEFmdtABC strains in laying hens as live vaccines was evaluated. The mutants are deficient in either the membrane channel TolC (ΔtolC) or the multi-drug efflux systems acrAB, acrEF and mdtABC (ΔacrABacrEFmdtABC). These strains have a decreased ability for gut and tissue colonization and are unable to survive in egg white, the latter preventing transmission of the vaccine strains to humans. Two groups of 30 laying hens were orally inoculated at day 1, 6 weeks and 16 weeks of age with 10(8) cfu of either vaccine strain, while a third group was left unvaccinated. At 24 weeks of age, the birds were intravenously challenged with 5 × 10(7) cfu Salmonella Enteritidis PT4 S1400/94. The vaccine strains were not shed or detected in the gut, internal organs or eggs, 2 weeks after the third vaccination. The strains significantly protected against gut and internal organ colonization, and completely prevented egg contamination by Salmonella Enteritidis under the conditions of this study. This indicates that Salmonella Enteritidis ΔtolC and ΔacrABacrEFmdtABC strains might be valuable strains for vaccination of layers against Salmonella Enteritidis.
Noise canceling in-situ detection (2014)

Technologies applicable to noise canceling in-situ NMR detection and imaging are disclosed. An example noise canceling in-situ NMR detection apparatus may comprise one or more of a static magnetic field generator, an alternating magnetic field generator, an in-situ NMR detection device, an auxiliary noise detection device, and a computer.
Depth-level-adaptive view synthesis for 3D video (2010)

In the multiview video plus depth (MVD) representation for 3D video, a depth map sequence is coded for each view. In the decoding end, a view synthesis algorithm is used to generate virtual views from depth map sequences. Many of the known view synthesis algorithms introduce rendering artifacts especially at object boundaries. In this paper, a depth-level-adaptive view synthesis algorithm is presented to reduce the amount of artifacts and to improve the quality of the synthesized images. The proposed algorithm introduces awareness of the depth level so that no pixel value in the synthesized image is derived from pixels of more than one depth level. Improvements on objective quality of the synthesized views were achieved in five out of eight test cases, while the subjective quality of the proposed method was similar to or better than that of the view synthesis method used by Moving Picture Experts Group (MPEG).
Polyphase sequences with good correlation properties (2009)

Design of sequences with good auto and crosscorrelation properties is one of the main tasks in several applications, including multi-user radar, sonar, and communications. In this paper we describe a new construction of polyphase sequences with optimal correlation properties. The construction includes, as special cases, a family of finite chirps and two previously proposed families of communications sequences. The main tool used in the construction is the finite Zak transform. The construction suggests several further generalizations that can be obtained by operating exclusively on subgroups of the permutation group.
High-Performance Concurrency Control Mechanisms for Main-Memory\n Databases (2011)

A database system optimized for in-memory storage can support much higher\ntransaction rates than current systems. However, standard concurrency control\nmethods used today do not scale to the high transaction rates achievable by\nsuch systems. In this paper we introduce two efficient concurrency control\nmethods specifically designed for main-memory databases. Both use\nmultiversioning to isolate read-only transactions from updates but differ in\nhow atomicity is ensured: one is optimistic and one is pessimistic. To avoid\nexpensive context switching, transactions never block during normal processing\nbut they may have to wait before commit to ensure correct serialization\nordering. We also implemented a main-memory optimized version of single-version\nlocking. Experimental results show that while single-version locking works well\nwhen transactions are short and contention is low performance degrades under\nmore demanding conditions. The multiversion schemes have higher overhead but\nare much less sensitive to hotspots and the presence of long-running\ntransactions.\n