gebhart/patrepeval huggingface dataset:
Edge-Cloud Orchestration: Strategies for Service Placement and Enactment (2019)

As devices existing at the edge of the network improve in their processing and data storage capacity, there is increasing potential to host and enact services on such devices. A workflow that was traditionally enacted on a data centre can be fragmented across both edge and data centre hosted resources. The following aspects are investigated in this work: (i) mechanisms for dividing a workflow across edge and cloud/data centre resources; (ii) service hosting environments that can be shared across edge and data centre resources; (iii) performance metrics that can influence service placement and selection. An "edge orchestrator" is a resource manager that makes such decisions on the behalf of a user application, and which may be centralised or distributed. An industry scenarios is used to illustrate decision points that influence such choices within an edge orchestrator. The overall objective considered is the completion of the workflow within some deadline constraint by the edge orchestrator.
Review: The Lacrimal Gland and Its Role in Dry Eye (2016)

The human tear film is a 3-layered coating of the surface of the eye and a loss, or reduction, in any layer of this film may result in a syndrome of blurry vision and burning pain of the eyes known as dry eye. The lacrimal gland and accessory glands provide multiple components to the tear film, most notably the aqueous. Dysfunction of these glands results in the loss of aqueous and other products required in ocular surface maintenance and health resulting in dry eye and the potential for significant surface pathology. In this paper, we have reviewed products of the lacrimal gland, diseases known to affect the gland, and historical and emerging dry eye therapies targeting lacrimal gland dysfunction.
The Effect of Very Bulky Groups on the Equilibrium of Penta- and Hexacoordinated Phosphoranes (2006)

The synthesis of dithio-diphenol 4 and sulfonyl-diphenol 5, both with very bulky groups, provided starting materials for reaction sequences that led to the formation of the very stable hexacoordinated phosphorane 2 and sensitive pentacoordinated phosphorane 3. Hexacoordination was established in 2 by an intramolecular donor interaction at the phosphorus center from an oxygen atom of the sulfonyl group present as part of the eight-membered ring. The solid state structures of 2 and 3 were established by X-ray analysis, as was that of phosphite 1 formed in the reaction sequence leading to 2. In solution, 2 has two forms existing in a dynamic equilibrium between a pentacoordinated and the more dominant hexacoordinated form as determined by 31P and 19F NMR spectroscopy. The high stability of 2 with respect to hydrolysis and alcoholysis reactions suggests that an associative process is responsible as the controlling reaction mechanism. Keywords: Cyclic sulfonyl derivativeshexacoordinationphosphoranessteric effectsX-ray crystallography The research presented here was supported by the donors of the Petroleum Research Fund, administered by the American Chemical Society, and is gratefully acknowledged. We thank the X-Ray Structural Characterization Laboratory at the Chemistry Department supported by University of Massachusetts and the National Science Foundation (Grant CHE-9974648). Notes a R = Σ|Fo‖−|Fc‖/Σ |Fo|. bRw (Fo 2) = {Σ w(Fo 2− Fc 2)2/Σ wFo 4}½. a Equilibrium denotes the existence of an isomeric penta-hexa coordination equilibrium in the solution. The solid state coordination at phosphorus is given in parentheses as found by X-ray analysis. b Bulkier α,α -dimethylbenzyl group is used here. c Highly electronegative pentafluorophenoxy groups are used for 11 and 13. d Phosphite 13 has P─O donor interactionCitation 13 that is as strong as that found in phosphoranes. e Compounds 11 and 12 deviate considerably from the Berry coordinate.
Saving Honors in the Age of Standardization (2006)

Iwent to my first National Collegiate Honors Council conference just this last yearand was sitting in a session on national scholarships when the phrase “learning out-comes ” came up. I turned to the woman behind me with whom I’d been briefly chat-ting before the session began and asked if this kind of evaluative structure was being implemented at her university. She rolled her eyes. “We’re all just sick of it, ” she said. “When I list my ‘learn-ing outcomes ’ on my syllabuses, I just want to say, ‘I have no idea what we’ll learn.’” It is no secret that educational institutions across the nation have in recent years been encouraged, urged, and forced to adopt a lexicon that seems better suited to the worlds of corporations and governments. In fact, according to Charles Miller, the business executive heading up the presidentially-appointed Commission on the Future of Higher Education, “levers ” like the accreditation process can and should be used to push educational reforms that will utilize standardized testing to measure stu-dent learning at all levels of higher education. At the same time that my colleagues in the English Department have decried the use of terms like “clients ” and “cus-tomers ” to describe our students, our upper administration has adopted a “scorecard”
Pridopidine activates neuroprotective pathways impaired in Huntington Disease (2016)

Pridopidine has demonstrated improvement in Huntington Disease (HD) motor symptoms as measured by secondary endpoints in clinical trials. Originally described as a dopamine stabilizer, this mechanism is insufficient to explain the clinical and preclinical effects of pridopidine. This study therefore explored pridopidine's potential mechanisms of action. The effect of pridopidine versus sham treatment on genome-wide expression profiling in the rat striatum was analysed and compared to the pathological expression profile in Q175 knock-in (Q175 KI) vs Q25 WT mouse models. A broad, unbiased pathway analysis was conducted, followed by testing the enrichment of relevant pathways. Pridopidine upregulated the BDNF pathway (P = 1.73E-10), and its effect on BDNF secretion was sigma 1 receptor (S1R) dependent. Many of the same genes were independently found to be downregulated in Q175 KI mice compared to WT (5.2e-7 < P < 0.04). In addition, pridopidine treatment upregulated the glucocorticoid receptor (GR) response, D1R-associated genes and the AKT/PI3K pathway (P = 1E-10, P = 0.001, P = 0.004, respectively). Pridopidine upregulates expression of BDNF, D1R, GR and AKT/PI3K pathways, known to promote neuronal plasticity and survival, as well as reported to demonstrate therapeutic benefit in HD animal models. Activation of S1R, necessary for its effect on the BDNF pathway, represents a core component of the mode of action of pridopidine. Since the newly identified pathways are downregulated in neurodegenerative diseases, including HD, these findings suggest that pridopidine may exert neuroprotective effects beyond its role in alleviating some symptoms of HD.
Device for rapid quantification of human carotid baroreceptor-cardiac reflex responses (1986)

We designed, constructed, and evaluated a new device to characterize the human carotid baroreceptor-cardiac reflex response relation rapidly. We designed this system for study of reflex responses of astronauts before, during, and after space travel. The system comprises a new tightly sealing silicone rubber neck chamber, a stepping motor-driven electro-deposited nickel bellows pressure system, capable of delivering sequential R-wave-triggered neck chamber pressure changes between +40 and -65 mmHg, and a microprocessor-based electronics system for control of pressure steps and analysis and display of responses. This new system provokes classic sigmoid baroreceptor-cardiac reflex responses with threshold, linear, and saturation ranges in most human volunteers during one held expiration.
Antimalarial Activity of the Anticancer Histone Deacetylase Inhibitor SB939 (2012)

Histone deacetylase (HDAC) enzymes posttranslationally modify lysines on histone and nonhistone proteins and play crucial roles in epigenetic regulation and other important cellular processes. HDAC inhibitors (e.g., suberoylanilide hydroxamic acid [SAHA; also known as vorinostat]) are used clinically to treat some cancers and are under investigation for use against many other diseases. Development of new HDAC inhibitors for noncancer indications has the potential to be accelerated by piggybacking onto cancer studies, as several HDAC inhibitors have undergone or are undergoing clinical trials. One such compound, SB939, is a new orally active hydroxamate-based HDAC inhibitor with an improved pharmacokinetic profile compared to that of SAHA. In this study, the in vitro and in vivo antiplasmodial activities of SB939 were investigated. SB939 was found to be a potent inhibitor of the growth of Plasmodium falciparum asexual-stage parasites in vitro (50% inhibitory concentration [IC(50)], 100 to 200 nM), causing hyperacetylation of parasite histone and nonhistone proteins. In combination with the aspartic protease inhibitor lopinavir, SB939 displayed additive activity. SB939 also potently inhibited the in vitro growth of exoerythrocytic-stage Plasmodium parasites in liver cells (IC(50), ~150 nM), suggesting that inhibitor targeting to multiple malaria parasite life cycle stages may be possible. In an experimental in vivo murine model of cerebral malaria, orally administered SB939 significantly inhibited P. berghei ANKA parasite growth, preventing development of cerebral malaria-like symptoms. These results identify SB939 as a potent new antimalarial HDAC inhibitor and underscore the potential of investigating next-generation anticancer HDAC inhibitors as prospective new drug leads for treatment of malaria.
Thermal atomic layer etching of crystalline aluminum nitride using sequential, self-limiting hydrogen fluoride and Sn(acac)2 reactions and enhancement by H2 and Ar plasmas (2016)

Thermal atomic layer etching (ALE) of crystalline aluminum nitride (AlN) films was demonstrated using sequential, self-limiting reactions with hydrogen fluoride (HF) and tin(II) acetylacetonate [Sn(acac)2] as the reactants. Film thicknesses were monitored versus number of ALE reaction cycles at 275 °C using in situ spectroscopic ellipsometry (SE). A low etch rate of ∼0.07 Å/cycle was measured during etching of the first 40 Å of the film. This small etch rate corresponded with the AlOxNy layer on the AlN film. The etch rate then increased to ∼0.36 Å/cycle for the pure AlN films. In situ SE experiments established the HF and Sn(acac)2 exposures that were necessary for self-limiting surface reactions. In the proposed reaction mechanism for thermal AlN ALE, HF fluorinates the AlN film and produces an AlF3 layer on the surface. The metal precursor, Sn(acac)2, then accepts fluorine from the AlF3 layer and transfers an acac ligand to the AlF3 layer in a ligand-exchange reaction. The possible volatile etch products are SnF(acac) and either Al(acac)3 or AlF(acac)2. Adding a H2 plasma exposure after each Sn(acac)2 exposure dramatically increased the AlN etch rate from 0.36 to 1.96 Å/cycle. This enhanced etch rate is believed to result from the ability of the H2 plasma to remove acac surface species that may limit the AlN etch rate. The active agent from the H2 plasma is either hydrogen radicals or radiation. Adding an Ar plasma exposure after each Sn(acac)2 exposure increased the AlN etch rate from 0.36 to 0.66 Å/cycle. This enhanced etch rate is attributed to either ions or radiation from the Ar plasma that may also lead to the desorption of acac surface species.
Distinguishing Monophonies From Polyphonies Using Weibull Bivariate Distributions (2010)

In the context of music indexation, it would be useful to have a precise information about the number of sources performing; a source is a solo voice or an isolated instrument which produces a single note at any time. This correspondence discusses the automatic distinction between monophonic music excerpts, where only one source is present, and polyphonic ones. Our method is based on the analysis of a “confidence indicator,” which gives the confidence (in fact its inverse) on the current estimated fundamental frequency (pitch). In a monophony, the confidence indicator is low. In a polyphony, the confidence indicator is higher and varies more. This leads us to compute the short term mean and variance of this indicator, take this 2-D vector as the observation vector and model its conditional distribution with Weibull bivariate models. This probability density function is characterized by five parameters. A method to perform their estimation is developed (in theory and practice). The decision is taken considering the maximum likelihood, computed over one second. The best configuration gives a global error rate of 6.3%, performed on a balanced corpus (18 minutes in total).
Resonance properties and microstructure of ultracompliant metallic nanoelectromechanical systems resonators synthesized from Al–32at.%Mo amorphous-nanocrystalline metallic composites (2008)

This study details the resonance properties of 20nm thick nanoelectromechanical system scale cantilevers fabricated from a metallic Al–32at.%Mo nanocomposite. The advantage of the Al–32at.%Mo alloy is that its strength and near-atomic surface smoothness enable fabrication of single-anchored metallic cantilevers with extreme length-to-thickness ratios, as high as 400:1. This yields uniquely compliant structures with exquisite force sensitivity. For example, an 8μm long, 20nm thick Al–32at.%Mo device has a spring constant of K≅280μN∕m. We show through transmission electron microscope analysis and continuum modeling that the relevant damping mechanisms are related to the device microstructure.
El Tribunal Supremo confirma que las retenciones del trabajo correspondientes a servicios prestados en alta mar se atribuyen al lugar donde radique el puerto-base (2019)

Hasta la ultima reforma de 2017, el Concierto Economico no establecia expresamente un punto de conexion en relacion con las retenciones a cuenta del IRPF sobre los rendimientos del trabajo personal de los contribuyentes que prestan sus servicios a bordo de embarcaciones que operan en alta mar, lo que dio lugar a numerosas controversias. Aunque actualmente esta cuestion ya esta regulada en el Concierto Economico, Inaki Alonso analiza en este articulo una reciente sentencia del Tribunal Supremo sobre esta cuestion, que confirma el criterio de la Junta Arbitral, y lo que a efectos del Concierto Economico debe entenderse por territorio comun
TURAC—A New Instrument Package for Radiation Budget Measurements and Cloud Detection (2005)

Abstract Atmospheric radiation flux measurements and the resulting surface radiation budget are important quantities for greenhouse effect and climate change investigations. Accurate net shortwave and longwave fluxes, in conjunction with numerical algorithms, also allow monitoring of the radiative effect of clouds and the nowcasting of the cloud amount. To achieve certain advantages on the accuracy of flux measurements a new instrument is developed that measures downward and upward shortwave and longwave radiation with the same sensors. Two high-quality instruments—a pyranometer for shortwave and a pyrgeometer for longwave measurements—are mounted on a pivotable sensor head, which is rotated up and down in 10-min intervals. To keep the instrument domes free from dew and ice, and to minimize the pyranometer thermal offset, both sensors are ventilated with slightly heated air. Additionally, a ventilated temperature and humidity sensor is integrated in the new instrument. The combination of measurements of radiation fluxes, temperature, and humidity allows for instrument use for autonomous and automatic cloud amount detection. The Temperature, Humidity, Radiation and Clouds (TURAC) sensor has been successfully tested under harsh alpine winter conditions, as well as under moderate lowland conditions. Comparisons to reference instruments showed all radiation fluxes to be within a maximum bias and rms difference of 1.6% or 1.4 W m−2 on daily averages.
Jitter control in QoS networks (2001)

We study jitter control in networks with guaranteed quality of service (QoS) from the competitive analysis point of view: we propose on-line algorithms that control jitter and compare their performance to the best possible (by an off-line algorithm) for any given arrival sequence. For delay jitter, where the goal is to minimize the difference between delay times of different packets, we show that a simple on-line algorithm using a buffer of B slots guarantees the same delay jitter as the best off-line algorithm using buffer space B/2. We prove that the guarantees made by our on-line algorithm hold, even for simple distributed implementations, where the total buffer space is distributed along the path of the connection, provided that the input stream satisfies a certain simple property. For rate jitter, where the goal is to minimize the difference between inter-arrival times, we develop an on-line algorithm using a buffer of size 2B+h for any h/spl ges/1, and compare its jitter to the jitter of an optimal off-line algorithm using buffer size B. We prove that our algorithm guarantees that the difference is bounded by a term proportional to B/h.
Observations Concerning the Existence and Reactivity of Free α-Amino Aldehydes as Chemical Intermediates:  Evidence for Epimerization-Free Adduct Formation with Various Nucleophiles (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTObservations Concerning the Existence and Reactivity of Free α-Amino Aldehydes as Chemical Intermediates: Evidence for Epimerization-Free Adduct Formation with Various NucleophilesAndrew G. Myers, Daniel W. Kung, and Boyu ZhongView Author Information Department of Chemistry and Chemical Biology Harvard University Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 2000, 122, 13, 3236–3237Publication Date (Web):March 21, 2000Publication History Received11 January 2000Published online21 March 2000Published inissue 1 April 2000https://pubs.acs.org/doi/10.1021/ja000136xhttps://doi.org/10.1021/ja000136xrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1121Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Adducts,Aldehydes,Anions,Mixtures,Solvents Get e-Alerts
Fibronectin as a Marker of Disease Severity in Critically Ill COVID-19 Patients (2022)

The SARS-CoV-2 virus alters the expression of genes for extracellular matrix proteins, including fibronectin. The aim of the study was to establish the relationship between different forms of fibronectin, such as plasma (pFN), cellular (EDA-FN), and proteolytic FN-fragments, and disease severity and mortality of critically ill patients treated in the intensive care unit. The levels of pFN, EDA-FN, and FN-fragments were measured in patients with a viral (N = 43, COVID-19) or bacterial (N = 41, sepsis) infection, using immunoblotting and ELISA. The level of EDA-FN, but not pFN, was related to the treatment outcome and was significantly higher in COVID-19 Non-survivors than in Survivors. Furthermore, EDA-FN levels correlated with APACHE II and SOFA scores. FN-fragments were detected in 95% of COVID-19 samples and the amount was significantly higher in Non-survivors than in Survivors. Interestingly, FN-fragments were present in only 56% of samples from patients with bacterial sepsis, with no significant differences between Non-survivors and Survivors. The new knowledge gained from our research will help to understand the differences in immune response depending on the etiology of the infection. Fibronectin is a potential biomarker that can be used in clinical settings to monitor the condition of COVID-19 patients and predict treatment outcomes.
Fabrication of Macroporous/Mesoporous Carbon Nanofiber Using CaCO<sub>3</sub> Nanoparticles as Dual Purpose Template and Its Application as Catalyst Support (2013)

The 1D hierarchical macroporous/mesoporous carbon nanofibers were prepared via electrospinning using PAN as carbon precursor and commercially available nano-CaCO3 as dual purpose template. During the carbonization process, nano-CaCO3 template decomposed and released CO2 to develop mesopores, and macropores were generated by subsequent acid removal of the as-formed CaO nanoparticles. This method is facile and low cost, allowing high-yield production of 1D hierarchical porous carbon nanofibers. The unique macro-/mesoporous structure of the nanofibers makes them a good support for anchoring palladium nanoparticles; the as-prepared catalyst shows high activity in various Suzuki cross-coupling reactions.
Accumulated Slip of a Friction-Controlled Mass Excited by Earthquake Motions (1974)

A rigid mass driven by Coulomb friction from a randomly moving foundation is used as a simple model of a possible earthquake isolation system for a stiff compact structure. The structure is protected from accelerations greater than that produced by the limiting friction at the expense of a residual relative displacement with respect to the foundation. The RMS residual displacement is predicted approximately, both analytically and by computer simulation. The analytical approximation makes use of equivalent linearization applied to a nonstationary response problem. The computer simulation marches out exact response histories for an ensemble of independent earthquake realizations. There is good agreement between the two predictions. The trade-off between peak accelerations and residual displacements for typical earthquake intensities is displayed.
Cloud-based manufacturing-as-a-service environment for customized products (2022)

An essential step in the peritoneal spread of ovarian cancer is the adhesion and implantation of tumor cells to the mesothelium layer. Integrin α5 and β1 have been reported to mediate the initial adhesion process and to correlate with disease survival in ovarian cancer. However, the molecular mechanism of integrin α5β1 dysregulation in tumorigenesis and metastasis remained enigmatic. In the present study, using the US NCI60 database, we identified miR-17 as a candidate regulator targeting both integrin α5 and β1. The level of miR-17 was evidently inversely correlated with that of α5 and β1 in ovarian cancer cell lines. Specifically, miR-17 bound directly to the 3' untranslated region (3'UTR) of α5 and β1 and suppressed their expression. Forced expression of miR-17 led to markedly diminished adhesion and invasion of ovarian cancer cells in vitro, and notably reduced metastatic nodules inside the peritoneal cavity in in vivo SKOV3 xenografts model. Moreover, ectopic expression of miR-17 in ovarian cancer cells resulted in repressed ILK phosphorylation as well as decreased production of active matrix metalloproteinase-2 (MMP-2). Our results indicated that miR-17 hampered ovarian cancer peritoneal propagation by targeting integrin α5 and β1. These findings supported the utility of miR-17/α5β1 to be considered as valuable marker for metastatic potential of ovarian cancer cells, or a therapeutic target in ovarian cancer treatment.