gebhart/patrepeval huggingface dataset:
Collaborative Filtering With User Interest Evolution (2011)

Effective recommendation is indispensable to customized or personalized services. The ease of collecting, integrating and analyzing vast amounts of data about customers and their purchase intentions/behaviors concerning different products or services has greatly fostered the interest in automated recommendations appropriate for individual customersâ needs, wants, or preferences. Collaborative filtering is a salient technique to support automated recommendations. However, the traditional collaborative filtering approach mainly relies on the assumption that all the given preferences are equally important, irrelevant of when a preference is collected. This assumption ignores the fact that a userâs interests may be changed over time, and the prediction outcome of the traditional collaborative filtering approach may be misguiding if the preferences given at different time are not distinguished appropriately. Therefore, we propose a new collaborative filtering approach to take user interest evolution into account. Specifically, a clustering algorithm is first adopted to group the similar items. Subsequently, for a user, the preference of each cluster is calculated by the given preferences on each item in this cluster as well as the corresponding timestamps. A userâs interest is then represented as a vector containing the preferences of all clusters. As a result, users with the most similar interest vectors to that of the active user will be chosen as his/her neighbors for collaborative recommendation. The experimental results demonstrate that our proposed approach improves the recommendation effectiveness in comparison with the traditional collaborative filtering approach.
Antioxidative, antibacterial and antifungal activity of the essential oil of wild‐growing <i>Satureja montana</i> L. from Dalmatia, Croatia (2012)

ABSTRACT The composition of the essential oil of Satureja montana was examined by gas chromatography–mass spectrometry and 1 H nuclear magnetic resonance spectroscopy. Forty‐three compounds were identified, representing approximately 99% of the oil. Major components were γ ‐terpinene (8.7%), p ‐cymene (16.9%) and carvacrol (44.5%). The oil was tested for its antioxidant activity by using the 1,1‐diphenyl‐2‐picryl hydrazyl assay and showed dose‐dependent free‐radical‐scavenging activity with an EC 50 value of 4.21 mg/ml. The antimicrobial effect of the essential oil was tested against six strains of Gram‐negative bacteria, seven strains of Gram‐positive bacteria and two fungi. The human pathogens Burkholderia cepacia ATCC 25416 (Gram negative) and Listeria innocua (Gram positive) were used in the investigation of S. montana for the first time. The minimum inhibitory concentration of the essential oil ranged from 0.625 to 5.0 µl/well for Gram‐negative bacteria, and from 0.312 to 1.125 µl/well for Gram‐positive bacteria. For the two fungi tested, Candida and Saccharomyces , the value was 0.234 µl/tube. The essential oil tested showed significant activity against fungi and Gram‐positive bacteria, especially Bacillus subtilis , Staphylococcus epidermidis and Listeria innocua , and among Gram‐negative bacteria extreme sensitivity was detected in Escherichia coli SY252, SY252 lpcA and ATTCC 25922 strains. Copyright © 2012 John Wiley & Sons, Ltd.
Parsing Movies in Context. (1991)

Traditional approaches in Multimedia systems force the user to segment video material into simple descriptions, which usually include endpoints and a brief text description in the form of keywords. We propose to segment contextual information into chunks rather than segmenting contiguous frames. The computer can help us organize sets of descriptions that are related to the recorded moving image: it can help us remember what we have shot. Such descriptions can overlap, be contained in, and even encompass a multitude of other descriptions. Parsing moving image sequences is reduced to simply parsing the contextual information which forms the description. Our approach, Stratification, also has important ramifications in terms of an elastic representation of moving images. Ambient sound can provide us with important contextual clues as to what is going on within the frames. Using audio to find patterns of content is an important step towards the eventual automatization of the logging process.
Two-dimensional electromagnetic cloak having a uniform thickness for elliptic cylindrical regions (2008)

A two-dimensional electromagnetic cloak recipe having a uniform thickness is presented for cloaked regions of elliptic cylindrical shape. The cloak material parameters are obtained from the spatial transformation approach. The effectiveness of the cloak design is verified by full-wave simulations of plane wave scattering from uncloaked and cloaked conducting elliptic cylinders. The proposed design provides a more practical cloak geometry when compared to previous designs that have the outer boundary limited only to a scaled version of the inner boundary.
Forecasting Time-Varying Correlation using the Dynamic Conditional Correlation (DCC) Model (2014)

Hedging strategies have become more and more complicated as assets being traded have become more interrelated to each other. Thus, the estimation of risks for optimal hedging does not involve only the quantification of individual volatilities but also include their pairwise correlations. Therefore a model to capture the dynamic relationships is necessary to estimate and forecast correlations of returns through time. Engle’s dynamic conditional correlation (DCC) model is compared with other models of correlation. Performance of the correlation models are evaluated in this paper using only the daily log returns of the closing prices of the Peso-Dollar Exchange Rate and Philippine Stock Exchange index. Ultimately, Engle’s DCC model is adopted because of its consistency with expectations. Though generally negative, correlation between these two returns is not really constant as the results indicated. The forecast evaluation of the models was divided into in-sample and out-of-sample forecast performance with short-term (i.e., 22-day, 60-day, and 125-day) and medium-term (250-day and 500-day) rolling window correlations, or realized correlations, as proxies for the actual correlation. Based on the root mean squared error and mean absolute error, the integrated DCC model showed optimal forecast performance for the in-sample correlation patterns while the mean-reverting DCC model had the most desirable forecast properties for dynamic long-run forecasts. Also, the Diebold-Mariano tests showed that the integrated DCC has greater predictive accuracy in terms of the 3-month realized correlations than the rest of the models.
Effective Live Cloud Migration (2016)

Cloud providers offer their IaaS services based on virtualization to enable multi-tenant and isolated environments for cloud users. Currently, each provider has its own proprietary virtual machine (VM) manager, called the hypervisor. This has resulted in tight coupling of VMs to their underlying hardware hindering live migration of VMs to different providers. A number of user-centric approaches have been proposed from both academia and industry to solve this issue. However, these approaches suffer limitations in terms of performance (migration downtime), flexibility (decoupling VMs from underlying hardware) and security (secure live migration). This paper proposes LivCloud to overcome such limitations. An open-source cloud orchestrator, a developed transport protocol, overlay network and secured migration channel are crucial parts of LivCloud to achieve effective live cloud migration. Moreover, an initial evaluation of LAN live migration in nested virtualization environment and between different hypervisors has been considered to show the migration impact on network throughput, network latency and CPU utilization. The evaluation has demonstrated the need for optimization within the LAN environment.
Novel Short-Chain Quinones to Treat Vision Loss in a Rat Model of Diabetic Retinopathy (2021)

Diabetic retinopathy (DR), one of the leading causes of blindness, is mainly diagnosed based on the vascular pathology of the disease. Current treatment options largely focus on this aspect with mostly insufficient therapeutic long-term efficacy. Mounting evidence implicates mitochondrial dysfunction and oxidative stress in the central etiology of DR. Consequently, drug candidates that aim at normalizing mitochondrial function could be an attractive therapeutic approach. This study compared the mitoprotective compounds, idebenone and elamipretide, side-by-side against two novel short-chain quinones (SCQs) in a rat model of DR. The model effectively mimicked type 2 diabetes over 21 weeks. During this period, visual acuity was monitored by measuring optokinetic response (OKR). Vision loss occurred 5-8 weeks after the onset of hyperglycemia. After 10 weeks of hyperglycemia, visual function was reduced by 65%. From this point, the right eyes of the animals were topically treated once daily with the test compounds. The left, untreated eye served as an internal control. Only three weeks of topical treatment significantly restored vision from 35% to 58-80%, while visual acuity of the non-treated eyes continued to deteriorate. Interestingly, the two novel SCQs restored visual acuity better than idebenone or elamipretide. This was also reflected by protection of retinal pathology against oxidative damage, retinal ganglion cell loss, reactive gliosis, vascular leakage, and retinal thinning. Overall, mitoprotective and, in particular, SCQ-based compounds have the potential to be developed into effective and fast-acting drug candidates against DR.
Distillation and Vapor Pressure Measurement in Petroleum Products (2008)

Description Twelve comprehensive chapters give you the latest practical information regarding distillation and vapor pressure measurement of petroleum products, as well as the significance of distillation and vapor pressure data in various petroleum products. The emphasis is on practical applications, rather than scientific technology. Manual 51 is a hands-on, practical reference manual for test operators, laboratory technicians, laboratory technologist, research workers, laboratory managers, and others, who need to have a good understanding of the routine measurement test method and procedures used to determine the characteristics and properties of various petroleum products. It provides useful information for the practitioners of routine petroleum test measurements and offers insight on how these measured properties apply to and affect the performance of these products.
Experience Management. The Fraunhofer IESE Experience Factory (2022)

Experience Management (EM) is an area that is increasingly gaining importance. Its roots lie in Experimental Software Engineering ("Experience Factory"), in Artificial Intelligence ("Case-Based Reasoning"), and in Knowledge Management. EM is comprised of the dimensions methodology, technical realization, organization, and management. It includes technologies, methods, and tools for identifying, collecting, documenting, packaging, storing, generalizing, reusing, adapting, and evaluating experience knowledge, as well as for development, improvement, and execution of all knowledge-related processes. The main difference between experience knowledge and general knowledge is the fact that normally, a (more or less) continuous "stream of knowledge" must be processed. Within this paper, we present some basic methods of EM, using the Fraunhofer IESE Experience Factory as an example, which, after a one-year trial run, has been in regular operation since the beginning of this year.
Regions of Melanocortin 2 (MC2) Receptor Accessory Protein Necessary for Dual Topology and MC2 Receptor Trafficking and Signaling (2008)

MRAP, melanocortin 2 (MC2) receptor accessory protein, is required for trafficking by the MC2 (ACTH) receptor. MRAP is a single transmembrane protein that forms highly unusual antiparallel homodimers. We used molecular complementation to ask where MRAP achieves dual topology. Fragments of yellow fluorescent protein (YFP) were fused to the NH2 or COOH terminus of MRAP such that YFP fluorescence could occur only in antiparallel homodimers; fluorescence was present in the endoplasmic reticulum. MRAP retained dual topology after deletion of most of the amino terminus. In contrast, deletion of residues 31-37, just NH2-terminal to the transmembrane domain, forced MRAP into a single Nexo/Ccyt orientation and blocked its ability to promote MC2 receptor trafficking and homodimerize. When the transmembrane domain of MRAP was replaced with the corresponding region from RAMP3, dual topology was retained but MRAP was inactive. Insertion of MRAP residues 29-37 conferred dual topology to RAMP3, normally in an Nexo/Ccyt orientation. When expressed with MRAPDelta1-30, MRAPDelta10-20, or MRAPDelta21-30, MC2 receptor was localized on the plasma membrane but unable to respond to ACTH. Residues 18-21 of MRAP were critical; MC2 receptor expressed with MRAP(18-21A) localized to the plasma membrane but did not bind 125I-ACTH or increase cAMP in response to ACTH. A newly identified MRAP homolog, MRAP2, lacks amino acids 18LDYI21 of MRAP and, like MRAP(18-21A), allows MC2 receptor trafficking but not signaling. MRAP2 with an LDYI insertion functions like MRAP. These results demonstrate that MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal.
Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment (1997)

N-acetylcysteine (NAC), an analogue and precursor of reduced glutathione, has been in clinical use for more than 30 yrs as a mucolytic drug. It has also been proposed for and/or used in the therapy and/or prevention of several respiratory diseases and of diseases involving an oxidative stress, in general. The objective of the present study was to evaluate the effect of long-term treatment with NAC on influenza and influenza-like episodes. A total of 262 subjects of both sexes (78% > or = 65 yrs, and 62% suffering from nonrespiratory chronic degenerative diseases) were enrolled in a randomized, double-blind trial involving 20 Italian Centres. They were randomized to receive either placebo or NAC tablets (600 mg) twice daily for 6 months. Patients suffering from chronic respiratory diseases were not eligible, to avoid possible confounding by an effect of NAC on respiratory symptoms. NAC treatment was well tolerated and resulted in a significant decrease in the frequency of influenza-like episodes, severity, and length of time confined to bed. Both local and systemic symptoms were sharply and significantly reduced in the NAC group. Frequency of seroconversion towards A/H1N1 Singapore 6/86 influenza virus was similar in the two groups, but only 25% of virus-infected subjects under NAC treatment developed a symptomatic form, versus 79% in the placebo group. Evaluation of cell-mediated immunity showed a progressive, significant shift from anergy to normoergy following NAC treatment. Administration of N-acetylcysteine during the winter, thus, appears to provide a significant attenuation of influenza and influenza-like episodes, especially in elderly high-risk individuals. N-acetylcysteine did not prevent A/H1N1 virus influenza infection but significantly reduced the incidence of clinically apparent disease.
ClientMarshal (2019)

Client devices must cooperate to share limited resources in wireless local area networks (WLANs). Standards exist for access points (APs), to use a more holistic view of the RF environment, to share information with clients (802.11v/k), allowing clients to make better performance-impacting decisions, e.g. choosing to roam between APs. Standards intended to lower the cost of these expensive control-plane operations (802.11r) also exist. In this paper, we use large scale measurements to show the limited adoption of existing client-based techniques. We propose ClientMarshal for enterprise WLANs, which provides network infrastructure more control over these decisions without modification to client device software. ClientMarshal divides the enterprise network into logical groups called cells, each consisting of a small number of neighboring APs operating on different channels. All APs belonging to the same cell broadcast the same wireless identity (BSSID) to client devices, and appear as a single virtual AP. The key enabler behind ClientMarshal is FreeSteer (FST), a novel protocol we develop that allows an AP to dynamically steer an associated client to another AP in the same cell based on various network measurements in order to improve overall network performance. This design also improves the roaming experience by bypassing traditional control-plane operations, avoiding significant overhead as well as client implementation defects. Using systematic evaluation and implementation on commodity APs, we show the efficacy and control of FST protocol in client steering. Compared to state-of-the-art approaches, FST can steer clients almost 2.5X faster, with 52% higher success rate, and reduce packet loss by more than 68%.
Mechanism of mast cell deficiency in mutant mice of mi/mi genotype: an analysis by co-culture of mast cells and fibroblasts (1990)

Mutant mice of mi/mi genotype are osteopetrotic and are deficient in mast cells. The osteopetrosis of mi/mi mice can be cured by bone marrow transplantation from congenic normal (+/+) mice, and therefore, the cause of the osteopetrosis is attributed to a defect of osteoclasts. Since both osteoclasts and mast cells are the progeny of multipotential hematopoietic stem cells, we examined whether mast cells were defective in mi/mi mice. In spite of the deficiency of mast cells in tissues of mi/mi mice, mast cells did develop when spleen cells of mi/mi mice were cultured with pokeweed mitogen-stimulated spleen cell conditioned medium (PWM-SCM). The proliferative response of cultured mast cells (CMC) derived from mi/mi mice to PWM-SCM was comparable with that of CMC from +/+ mice. In contrast, when CMC were co-cultured with the NIH/3T3 fibroblast cell line in culture medium lacking PWM-SCM, only +/+ CMC entered into the S phase of the cell cycle and were maintained; mi/mi CMC gradually disappeared. Moreover, fibroblasts derived from the skin of mi/mi mice normally supported the proliferation of +/+ CMC. Thus, the mast cell deficiency of mi/mi mice appears to be due to the inability of mi/mi mast cells to respond to the proliferative stimulus presented by fibroblasts.
Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence (2001)

The effects of the polypeptide hormone prolactin (PRL) in the development and regulation of benign prostate hyperplasia (BPH) and also in prostate cancer are not very well characterized. This study examines the action of PRL, either alone or in association with androgens [testosterone (T) or dihydrotestosterone (DHT)], in the rat prostate gland. The effects of PRL and androgens were investigated after 30 and 60 days in control, castrated, castrated with a substitutive implant of T or DHT, and sham-operated Wistar rats. To enhance PRL release, we induced hyperprolactinemia by administering chronic injections of sulpiride (40 mg. kg(-1). day(-1)). Chronic hyperprolactinemia induces enlargement and inflammation of the lateral rat prostate without any histological changes on ventral and dorsal lobes. We also demonstrate that hyperprolactinemia induces Bcl-2 overexpression in the lateral rat prostate and that this could inhibit the level of apoptosis. The in vivo model established here is a useful in vivo approach for studying the hormonal regulation of normal and pathological prostate development.
Cloning and Sequencing of a cDNA for Poplar Endo-1,4-rβ-Glucanase (1995)

A cDNA for poplar endo-1,4-beta-glucanase was cloned by use of a synthetic oligonucleotide as probe. The probe was designed on the basis of the N-terminal amino acid sequence of the beta-glucanase from suspension-cultured poplar cells (Populus alba L.), and by complete nucleotide sequence of the cDNA was determined. The 1,614-bp cDNA contained an open reading frame of 1,482 base pairs, encoding 494 amino acids. Removal of a putative signal sequence from the deduced amino acid sequence of the polypeptide yielded a mature protein of 467 amino acids. Comparison of deduced amino acid sequences revealed that the poplar endo-1,4-beta-glucanase was 80% and 70% identity to avocado fruit and bean abscission endo-1,4-beta-glucanases, respectively. Hydropathy plot analysis of the deduced amino acid sequence suggests that poplar endo-1,4-beta-glucanase belongs to family E in terms of the cellulase catalytic domain, and avocado fruit and abscission bean endo-1,4-beta-glucanases also belong to this family. 2,4-D markedly increased the level of the endo-1,4-beta-glucanase mRNA in cultured cells, while GA3, benzyladenine and abscisic acid each repressed transcription of this mRNA. The transcript was also detected in the roots and stems of intact plants, although the level of mRNA was much lower in intact tissues than in cultured cells. Genomic Southern analysis indicated that a small family of gene for endo-1,4-beta-glucanase exists in poplar.
Optical subcarrier multiplexing transmission for base station with adaptive array antenna (2001)

We propose utilizing a radio-over-fiber technique of optical subcarrier-multiplexing transmission for radio base stations (BSs) with adaptive array antennas. The proposed system can be constructed at low cost since only one optical transmitter and receiver is required for a center station and a BS. Moreover, relative phases among antenna branches are insensitive to equivalent length fluctuation of an optical fiber.
CD4 T cells transduced with CD80 and 4-1BBL mRNA induce long-term CD8 T cell responses resulting in potent antitumor effects (2014)

Meeting abstracts Therapeutic cancer vaccines are an attractive alternative to conventional therapies to treat malignant tumors, and more importantly, to prevent recurrence after primary therapy. However, the availability of professional antigen-presenting cells (APCs) has been restricted by
"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides (1994)

A series of 9-(acylamino)doxycycline derivatives has been prepared. These analogs exhibit good activity against both tetracycline sensitive and tetracycline resistant Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria that are encoded with the efflux and ribosomal resistance gene factors. N,N-Dialkylglycylamido derivatives possessed the highest activity. Replacement of glycine moiety with other amino acids did not further enhance the activity.
Transadmittance mode universal filter based on MOCCCII (2009)

A transadmittance mode universal filter based on multiple output current controlled conveyors (MO-CCCII) is presented. It employs three MO-CCCIIs and two grounded capacitors and provides all standard filter responses namely low pass, high pass, band pass, notch and all pass at high output impedance. The filter enjoys low sensitivity performance and low component spread; and exhibits electronic and orthogonal tunability of filter parameters via bias currents of MO-CCCII. The SPICE simulation results are illustrated to verify theory.
Structured Regression Gradient Boosting (2016)

We propose a new way to train a structured output prediction model. More specifically, we train nonlinear data terms in a Gaussian Conditional Random Field (GCRF) by a generalized version of gradient boosting. The approach is evaluated on three challenging regression benchmarks: vessel detection, single image depth estimation and image inpainting. These experiments suggest that the proposed boosting framework matches or exceeds the state-of-the-art.