gebhart/patrepeval huggingface dataset:
Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP (2007)

LATS (large tumor suppressor) or warts is a Ser/Thr kinase that belongs to the Ndr/LATS subfamily of AGC (protein kinase A/PKG/PKC) kinases. It is a tumor suppressor gene originally isolated from Drosophila and recently isolated from mice and humans. Drosophila or mice mutant for LATS develop tumors in various tissues. Recent studies in Drosophila demonstrate that LATS is a central player of an emerging tumor suppressor pathway called the Hippo-LATS/Warts pathway that suppresses tumor growth by regulating cell proliferation, cell growth, and cell death. Although tremendous progress has been made toward understanding the roles of LATS in tumorigenesis, the kinase substrates of LATS or downstream target proteins mediating LATS function remain largely unknown. In this study, we have provided convincing evidence that the LATS1 tumor suppressor can bind to and phosphorylate transcription regulator and oncogene YAP in vitro and in vivo. We have also identified HX(R/H/K)XX(S/T) as the consensus phosphorylation sequence for LATS/Ndr kinase substrates. Significantly, we have discovered that LATS1 inactivates YAP oncogenic function by suppressing its transcription regulation of cellular genes via sequestration of YAP in the cytoplasm after phosphorylation of YAP. Finally, by using microarray analysis, we have also identified many oncogenes or tumor suppressor genes up-regulated or down-regulated by YAP. These research findings will have profound impacts on our understanding of the molecular mechanism of the LATS tumor suppressor and the emerging Hippo-LATS/Warts pathway.
Characteristics of atomic layer deposited TiO2 films and their photocatalytic activity (2006)

Titanium dioxide thin films were grown by atomic layer deposition (ALD) at 100–250 °C with tetrakis-dimethyl-amido titanium, using H2O2 as a counter-reactant. We have explored the effects of deposition temperature and the reactant pulse and purge times on the film growth rate to optimize the ALD process of TiO2. The film growth rate decreased with growth temperature below 175 °C, but was saturated to 0.28Å∕cycle at 175–250 °C. All the as-deposited films were highly pure, and the root-mean-square roughness was less than 2.5% of the film thickness. The films deposited at 150 °C and above were polycrystalline with an anatase structure, whereas those deposited at 125 ° C were amorphous. There was no change of crystal structure after annealing the crystalline films at temperatures of 450–650 °C. All the crystalline films were shown to have a photocatalytic activity in decomposing methylene blue in an aqueous solution. The films prepared at higher deposition temperatures were shown to have a better photocatalytic activity in decomposing methylene blue.
Copper‐Catalyzed Oxidative Dehydrogenative C(sp<sup>3</sup>)−H Bond Amination of (Cyclo)Alkanes using NH‐Heterocycles as Amine Sources (2017)

A copper-catalyzed oxidative C(sp<sup>3</sup> )-H/N-H coupling of NH-heterocycles with affordable (cyclo)alkanes has been developed. This procedure involves C(sp<sup>3</sup> )-N bond formation through a radical pathway generated by homolytic cleavage of di-tert-butyl peroxide and trapping of the radical(s) by copper catalysts. The reaction tolerates a series of functional groups, such as bromo, fluoro, ester, ketone, nitrile, methyl, and methoxy. free-NH-containing indoles, pyrroles, pyrazoles, indazoles, and benzotriazoles are successfully N-alkylated.
France and the Grand Tour (2004)

France and the Grand Tour JeremyBlack , xii + 234. London, Basingstoke, New York: Palgrave Macmillan , 2003. £45.00 (ISBN 1 4039 0690 4)
Based on the Method of Fuzzy Clustering Analysis of the Smartphone Product Market (2012)

With an increasingly competitive market and the homogenization of products, the cultivation and building of the competitiveness of enterprises depends largely on the obtaining information in the business marketing, in order to respond to changes of the environment of market.Firstly, this paper describes the basic principles of fuzzy clustering analysis.Secondly, it describes the general steps and related concepts. At last, it classifies five smartphone brands effectively through the use of fuzzy clustering analysis method to combine quantitative and qualitative market for smartphones. By the results, we obtain more realistic market conditions
Nonlinear photonic crystal microdevices for optical integration (2003)

A four-port nonlinear photonic crystal system is discussed that exhibits optical bistability with negligible backscattering to the inputs, making it particularly suitable for integration with other active devices on the same chip. Devices based on this system can be made to be small [O(lambda3)] in volume, have a nearly instantaneous response, and consume only a few milliwatts of power. Among many possible applications, we focus on an all-optical transistor and integrated optical isolation.
Recovering boundary shape and conductivity in electrical impedance tomography (2013)

Electrical impedance tomography (EIT) aims to reconstruct the electric conductivity inside a physical body from current-to-voltage measurements at the boundary of the body. In practical EIT one often lacks exact knowledge of the domain boundary, and inaccurate modeling of the boundary causes artifacts in the reconstructions. A novel method is presented for recovering the boundary shape and an isotropic conductivity from EIT data. The first step is to determine the minimally anisotropic conductivity in a model domain reproducing the measured EIT data. Second, a Beltrami equation is solved, providing shape-deforming reconstruction. The algorithm is applied to simulated noisy data from a realistic electrode model, demonstrating that approximate recovery of the boundary shape and conductivity is feasible.
Thermal shock resistance ceramic insulator (2023)

Thermal shock resistant cermet insulators containing 0.1-20 volume % metal present as a dispersed phase. The insulators are prepared by a process comprising the steps of (a) providing a first solid phase mixture of a ceramic powder and a metal precursor; (b) heating the first solid phase mixture above the minimum decomposition temperature of the metal precursor for no longer than 30 minutes and to a temperature sufficiently above the decomposition temperature to cause the selective decomposition of the metal precursor to the metal to provide a second solid phase mixture comprising particles of ceramic having discrete metal particles adhering to their surfaces, said metal particles having a mean diameter no more than 1/2 the mean diameter of the ceramic particles, and (c) densifying the second solid phase mixture to provide a cermet insulator having 0.1-20 volume % metal present as a dispersed phase.
Rock susceptibility meter (1976)

The main advantages of this improved instrument for the measurement of the isotropic susceptibility of rock specimens lie in the use of commercial electronic units, the constancy of the calibration and the simplicity and speed of operation. Range 4*10-7-320*10-3 (SI); sensitivity 1*10-7 (SI).
Review of Dynamic Impairment-Aware Routing and Wavelength Assignment Techniques in All-Optical Wavelength-Routed Networks (2011)

Since light-paths are the basic connections in wavelength routed networks, their effective establishment is very important. Routing and Wavelength Assignment (RWA) techniques can be divided into two categories. The first category (pure RWA) concentrates on setting up light-paths under the assumption of an ideal physical layer. However, this assumption could be suitable for opaque networks, where a signal is regenerated at each optical switch along its path. On the other hand, as an optical signal propagates along a light-path to its destination in a transparent (all-optical) network, the signal's quality degrades because there is no signal regeneration, thus increasing Bit-Error-Rate (BER) of the signal. However, users would not accept a light-path with a high BER. Even it is not acceptable if the establishment of a light-path causes the BER of other existing light-paths to become unacceptably high. Therefore, considering physical layer impairments, the quality of a light-path must be checked during the light-path setup in the second category. In this article, the operations of dynamic RWA techniques proposed in transparent networks for the second category are reviewed in detail. These techniques are called Quality of Transmission Aware (QoT-aware) RWA and are grouped in two groups: integrated QoT and RWA, and QoT after Pure RWA. Each group can be further divided into direct modelling and indirect modelling sub-groups. A comprehensive discussion is also provided to compare dynamic QoT-aware RWA techniques based on different network and physical layer parameters.
Transcriptional territories in the genome. (2002)

An analysis of numerous Drosophila microarray experiments reveals that the genome has many large groups of adjacent genes that are expressed similarly but are not functionally related.
Maternal ancestry and population history from whole mitochondrial genomes (2015)

MtDNA has been a widely used tool in human evolutionary and population genetic studies over the past three decades. Its maternal inheritance and lack of recombination have offered the opportunity to explore genealogical relationships among individuals and to study the frequency differences of matrilineal clades among human populations at continental and regional scales. The whole mtDNA genome sequencing delivers molecular resolution that is sufficient to distinguish patterns that have arisen over thousands of years. However, mutation rate is highly variable among the functional and non-coding domains of mtDNA which makes it challenging to obtain accurate split dates of the mitochondrial clades. Due to the shallow coalescent time of mitochondrial TMRCA at approximately 100 to 200 thousand years (ky), mtDNA data have only limited power to inform us about the more distant past and the early stages of human evolutionary history. The variation shared by mitochondrial genomes of individuals drawn from different continents outside Africa has been used to illuminate the details of the colonization process of the Old World, whereas regional patterns of variation have been at the focus of studies addressing questions of a more recent time scale. In the era of whole nuclear genome sequencing, mitochondrial genomes are continuing to be informative as a unique tool for the assessment of female-specific aspects of the demographic history of human populations.
CTCF: the protein, the binding partners, the binding sites and their chromatin loops (2013)

CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some tissue-specific, others ultra-conserved. It can act as a transcriptional activator, repressor and insulator, and it can pause transcription. CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies. It can attract many other transcription factors to chromatin, including tissue-specific transcriptional activators, repressors, cohesin and RNA polymerase II, and it forms chromatin loops. Yet, or perhaps therefore, CTCF's exact function at a given genomic site is unpredictable. It appears to be determined by the associated transcription factors, by the location of the binding site relative to the transcriptional start site of a gene, and by the site's engagement in chromatin loops with other CTCF-binding sites, enhancers or gene promoters. Here, we will discuss genome-wide features of CTCF binding events, as well as locus-specific functions of this remarkable transcription factor.
Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses (2006)

Natural and genetically modified oncolytic viruses have been systematically tested as anticancer therapeutics. Among this group, conditionally replicative adenoviruses have been developed for a broad range of tumors with a rapid transition to clinical settings. Unfortunately, clinical trials have shown limited antitumor efficacy partly due to insufficient viral delivery to tumor sites. We investigated the possibility of using mesenchymal progenitor cells (MPC) as virus carriers based on the documented tumor-homing abilities of this cell population. We confirmed preferential tumor homing of MPCs in an animal model of ovarian carcinoma and evaluated the capacity of MPCs to be loaded with oncolytic adenoviruses. We showed that MPCs were efficiently infected with an adenovirus genetically modified for coxsackie and adenovirus receptor-independent infection (Ad5/3), which replicated in the cell carriers. MPCs loaded with Ad5/3 caused total cell killing when cocultured with a cancer cell line. In an animal model of ovarian cancer, MPC-based delivery of the Ad5/3 increased the survival of tumor-bearing mice compared with direct viral injection. Further, tumor imaging confirmed a decrease in tumor burden in animals treated with oncolytic virus delivered by MPC carriers compared with the direct injection of the adenovirus. These data show that MPCs can serve as intermediate carriers for replicative adenoviruses and suggest that the natural homing properties of specific cell types can be used for targeted delivery of these virions.
Substituent-Dependent Photoinduced Intramolecular Charge Transfer in <i>N</i>-Aryl-Substituted <i>trans</i>-4-Aminostilbenes (2004)

The photochemical behavior of trans-4-(N-arylamino)stilbene (1, aryl = 4-substituted phenyl) in solvents more polar than THF is strongly dependent on the substituent in the N-aryl group. This is attributed to the formation of a twisted intramolecular charge transfer (TICT) state for those with a methoxy (1OM), methoxycarbonyl (1CO), or cyano (1CN) substituent but not for those with a methyl (1Me), hydrogen (1H), chloro (1Cl), or trifluoromethyl (1CF) substituent. On the basis of the ring-bridged model compounds 3-6, the TICT states for 1CN and 1CO result from the twisting of the anilino-benzonitrilo C-N bond, but for 1OM it is from the twisting of the stilbenyl-anilino C-N bond, both of which are distinct from the TICT states previously proposed for N,N-dimethylaminostilbenes.
Transient and steady-state rotation center of vehicle dynamics (2017)

The purpose of this paper is to show the effect of acceleration -variable forward velocity-, on the steady-state and transient responses of turning vehicles and the resulted path of motion of the vehicle. Comparing the responses of the vehicle will be used to prove that there is a negligible difference between the steady-state and transient center of rotation of the vehicle in engineering applications. To show that vehicles are working close to their steady-state conditions even at transient stage, we examine a vehicle in two maneuvers. In the first one, the vehicle is assumed to be moving at a constant forward speed and experiencing a step steer angle change. In the second maneuver, the vehicle experiences a lane change steering input. The transient response of the vehicle, as well as the required time to achieve the steady-state conditions will be analyzed.
Some Like It Cold: Initial Testing Results for Cryogenic Computing Components (2019)

With the exponential growth of bandwidth demands on present data centers, we are researching the feasibility of deploying cryogenic DRAM based memory subsystems for the next generation of higher bandwidth, more efficient, lower cost and smaller footprint data centers of the future. As part of our early research, we are designing DRAM based subsystems that operate at 77K and are submerged in liquid nitrogen. To effectively test the memory subsystem at cryogenic temperatures, creative test methods must be employed. This paper illustrates the test setups, procedures and methodologies that were used to successfully test DRAM based subsystems at cryogenic temperatures
Molecular mechanisms of xylose utilization by <scp><i>P</i></scp><i>seudomonas fluorescens</i>: overlapping genetic responses to xylose, xylulose, ribose and mannitol (2015)

Bacterial degradation of xylose is sequentially mediated by two enzymes - an isomerase (XutA) and a xylulokinase (XutB) - with xylulose as an intermediate. Pseudomonas fluorescens SBW25, though capable of growth on xylose as a sole carbon source, encodes only one degradative enzyme XutA at the xylose utilization (xut) locus. Here, using site-directed mutagenesis and transcriptional assays, we have identified two functional xylulokinase-encoding genes (xutB1 and xutB2) and further show that expression of xutB1 is specifically induced by xylose. Surprisingly, xylose-induced xutB1 expression is mediated by the mannitol-responsive regulator MtlR, using xylulose rather than xylose as the direct inducer. In contrast, expression of the xutA operon is regulated by XutR - a transcriptional activator of the AraC family - in a xylose-, xylulose- and ribose-dependent manner. Detailed genetic and biochemical analyses of XutR, including DNase I footprinting assays, suggest an unconventional model of XutR regulation that does not involve DNA-looping, a mechanism typically found for AraC-type regulators from enteric bacteria. XutR functions as a dimer and recognizes two inverted repeat sequences, but binding to one half site is weak thus requiring an inducer molecule such as xylose for activation.
Combined Data Encryption and Reliability Using McEliece's Public-key Cryptosystem (1994)

McEliece has proposed a public-key cryptosystem that derives its security from the intractibility of decoding a general linear error-correcting block code. In McEliece's system, a Goppa code is used to correct the errors introduced intentionally by the transmitter. In this paper, we explore a series of modification that also allows the code in McEliece's system to be used for the correction and/or detection of errors caused by noise on the communication channel. A tradeoff is thus established between security and reliability. The performance of the proposed systems is considered for an M-state discrete Markovian channel in which each state is associated with a binary symmetric channel with fixed bit error rate. The Goppa code is used in standard forward error correcting mode, as well as in a type-I hybrid-ARQ protocol and an adaptive hybrid-ARQ protocol. A detailed performance analysis is provided, with specific examples for codes of length 1024 bits.
Dilated Hourglass Networks for Human Pose Estimation (2018)

Human pose estimation, a research hotspot of computer vision, has been a key and hard task. Recently, significant progress has been achieved using the newly emergent deep convolutional neural network technique. Many methods first apply the bottom-up and top-down structure, which uses first downsampling and then upsampling. This structure can capture multi-scale feature but lead to loss of information due to downsampling. In this work, we propose a Dilated Convolutional Module (DCM) based on dilated convolution and skip connections. The proposed module, which aims to reduce the loss of information, can expand receptive field and reduce the times of downsampling. Using DCMs as building blocks, this work proposes a novel convolutional network named Dilated Hourglass Network, based on Stacked Hourglass Network. The proposed network is compared with the Stacked Hourglass Network on the standard benchmarks MPII dataset for human pose estimation, which shows that the proposed network achieves a notable progress.
Determination of ultratrace levels of fluorine in water and urine samples by a gas chromatographic/atmospheric pressure helium microwave induced plasma emission spectrometric system (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of ultratrace levels of fluorine in water and urine samples by a gas chromatographic/atmospheric pressure helium microwave induced plasma emission spectrometric systemKoichi. Chiba, Kazuo. Yoshida, Kiyoshi. Tanabe, Masanao. Ozaki, Hiroki. Haraguchi, J. D. Winefordner, and Keiichiro. FuwaCite this: Anal. Chem. 1982, 54, 4, 761–764Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ac00241a036https://doi.org/10.1021/ac00241a036research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ku-Band Linearly Polarized Omnidirectional Planar Filtenna (2012)

A linearly polarized omnidirectional planar filtenna at Ku-band is presented in this letter. It is a seamless and incorporate design of an inductive window bandpass filter and a planar coaxial collinear (COCO) radiation element. The radiation element has a linearly polarized omnidirectional radiation characteristic. The substrate integrated waveguide filter is used for RF channel selection as well as a balun. The proposed filtenna has merits of light weight, compact size, low cost, and easy integration with other planar circuits. Simulation and measurement results show that the radiation characteristics of the filtenna keep nearly no change within the working band, while unwanted signals at out-band can be effectively filtered.
Accelerating Monte Carlo simulations of photon transport in a voxelized geometry using a massively parallel graphics processing unit (2009)

The reported results show that GPUs are currently a good alternative to CPUs for the simulation of radiation transport. Since the performance of GPUs is currently increasing at a faster pace than that of CPUs, the advantages of GPU-based software are likely to be more pronounced in the future.
Power and energy measurements of transient electric discharge (1978)

A simple and inexpensive calculating device for electrical power and energy of transient electric discharges is described. The calculation is made by multiplication of the voltage and current of the discharge by use of wideband integrated circuits.
Inflammatory Bowel Disease (2014)

Inflammatory bowel disease (IBD) is an immunological disorder, encompassing Crohn’s disease and ulcerative colitis, which are characterized by chronic intestinal inflammation targeted at harmless commensal bacteria and food antigens. Although the aetiology of IBD remains unclear, environmental factors in susceptible individuals appear to trigger immunological responses that inflame and damage tissues of the digestive tract. Prevalence of IBD is markedly higher in industrialized and affluent countries [1] (see Fig. 1). Evidence of a major underlying role for genetic predisposition to IBD raises the likelihood that the origins of disease and the susceptibility of the current human ‘immunome’ is the evolutionary consequence of marked and prolonged genetic selective pressure exerted by infectious pathogens [3].