gebhart/patrepeval huggingface dataset:
Abstract 2203: Targeting monoclonal antibodies to the tumor microenvironment for cancer immunotherapy (2016)

Abstract Therapeutic antibodies and immune checkpoint inhibitors can be delivered more efficiently to the tumor microenvironment (TME) by targeting the exposed collagenous (XC) proteins at the site/s of tumor invasion, stroma formation, and neoangiogenesis.Purpose: To assess the ability of bifunctional fusion polypepetides (mAb-Tropins) to selectively deliver monoclonal antibodies (mAbs) to the TME in tumor-bearing nude mice.Materials and Methods: Synthetic peptide probes and polypeptide aptamers (25-45 aa), fluorescein-labeled IgGs, and an anti-VEGF human mAb were tested in vitro in exposed collagen (XC)-agarose binding assays, in HUVEC cultures, and in vivo in a human xenograft model of pancreatic cancer in nude mice.Results: The XC-targeted mAb-Tropins, bound non-covalently to FITC-labeled IgGs [but not to truncated F(Ab’)2 fragments], exhibited selectivity for XC-agarose over control agarose matrices. Importantly, the biological activity of the XC/mAb-Tropin-bound anti-VEGF mAbs was fully preserved, as demonstrated by inhibition of endothelial cell proliferation in HUVEC cultures. In vivo, intense fluorescence was observed in tumors of mice injected with mAb-Tropin targeted IgGs at 15 and 60 minutes after intravenous injection, but not in non-targeted IgG-treated mice (see Figure below).Conclusions: Tumor XC-targeted mAb-Tropins are an effective method of delivering therapeutic mAbs precisely to the tumor compartments, with meaningful implications for cancer immunotherapy. Figure Figure Legend: The performance of mAb-Tropin 277 is evaluated in vitro in XC-binding assays and in vivo in a murine xenograft model of metastatic cancer. XC-agarose chromatography using mAb-Tropin 277 and FITC-IgGs, followed by stringent washing and analysis of column eluates and retentates (A,B), demonstrates aptamer-dependent binding of IgGs to XC-proteins (retentates), as well as depletion of the fluorescent IgGs from solution (column pass-through). The mAb-Tropin 277 dependent targeting of fluorescent IgGs (via the systemic circulation) to tumors is demonstrated in a murine metastatic cancer model (C). Taken together with the in vitro binding data—which showed that the bifunctional mAb-targeting onco-aptamers efficiently sequester IgGs (A) and concentrate the bound IgGs on collagen matrices (B)—this in vivo data indicates that mAb-Tropins concentrate and compartmentalize IgGs/mAbs within the TME (C). Citation Format: Frederick L. Hall, Sant P. Chawla, Neal S. Chawla, Erlinda M. Gordon. Targeting monoclonal antibodies to the tumor microenvironment for cancer immunotherapy. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2203.
Optische Kohärenztomographie-Angiographie mit dem Optovue-System (2017)

Die AngioVue-Technologie von Optovue für die optische Kohärenztomographie-Angiographie (OCT-A) basiert auf dem Bildgebungssystem AngioVue (Optovue Inc., Freemont, CA, USA) unter Verwendung des SSADA(split-spectrum amplitude-decorrelation angiography)-Algorithmus. Dieser Algorithmus ist darauf ausgelegt, die Dauer des Scan-Vorgangs zu minimieren. Er erkennt Bewegung im Blutgefäßlumen durch die Messung der Veränderungen in der reflektierten OCT-Signalamplitude bei aufeinanderfolgenden Querschnitt-Scans. Die Besonderheit der SSADA liegt in der Art, wie das OCT-Signal weiterverarbeitet wird, um die Flussmessung zu verbessern und das Signalrauschen der axialen Grundbewegung zu eliminieren. Konkret trennt der Algorithmus die OCT-Aufnahme in einzelne Spektralbänder auf und steigert dadurch die Anzahl verwertbarer Bild-Frames. Jeder neue Frame hat eine geringere axiale Auflösung, die weniger empfindlich gegenüber axialen Augenbewegungen infolge des pulsierenden Blutstroms ist. Die Technologie des AngioVue-Systems von Optovue ermöglicht eine quantitative Analyse. Sie liefert nummerische Daten über durchströmte sowie nicht durchströmte Areale und kann Flussdichtekarten erstellen. Diese aufbereiteten Messdaten könnten als Biomarker sowohl für die Diagnose als auch für die Überwachung des Krankheitsverlaufs und des Ansprechens auf eine Therapie dienen. Durchströmte Areale: Die Software berechnet das eingezeichnete Areal und das Gefäßareal in mm<sup>2</sup>. Sie ermöglicht auch den Vergleich aller Messungen einer Person. Nicht durchströmte Areale: Die Software zeigt die nicht durchbluteten Areale per Mausklick an. Ischämische Areale werden in Gelb dargestellt. Diese Areale können abgespeichert und mit anderen in der Studie abgeglichen werden. Mit dem Flussdichte-Tool lässt sich der prozentuale Anteil von vaskulären Arealen in En-Face-Angiogrammen messen. Die Analyse beruht auf einem ETDRS(Early Treatment Diabetic Retinopathy Study)-Raster, das wie die Dickenkarte auf die Makula zentriert ist. Das Tool ist sowohl für den inneren als auch für den äußeren Gefäßplexus geeignet. Übersetzung aus Dev Ophthalmol. Basel, Karger, 2016, vol 56, pp 6-12 (DOI:10.1159/000442770)
1468: Novel Cell Therapy Approaches for Renal Failure (2006)

You have accessJournal of UrologyPodium, Wednesday, May 24, 2006, 8:00 - 10:00 am1 Apr 20061468: Novel Cell Therapy Approaches for Renal Failure Akira Joraku, Toshihiko Machiguchi, James J. Yoo, and Anthony Atala Akira JorakuAkira Joraku More articles by this author , Toshihiko MachiguchiToshihiko Machiguchi More articles by this author , James J. YooJames J. Yoo More articles by this author , and Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33672-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1468: Novel Cell Therapy Approaches for Renal Failure." The Journal of Urology, 175(4S), p. 474 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 474 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Akira Joraku More articles by this author Toshihiko Machiguchi More articles by this author James J. Yoo More articles by this author Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Long-Term Spectro-Temporal and Static Harmonic Features for Voice Activity Detection (2010)

Accurate voice activity detection (VAD) is important for robust automatic speech recognition (ASR) systems. This paper proposes a statistical-model-based noise-robust VAD algorithm using long-term temporal information and harmonic-structure-based features in speech. Long-term temporal information has recently become an ASR focus, but has not yet been deeply investigated for VAD. In this paper, we first consider the temporal features in a cepstral domain calculated over the average phoneme duration. In contrast, the harmonic structures are well-known bearers of acoustic information in human voices, but that information is difficult to exploit statistically. This paper further describes a new method to exploit the harmonic structure information with statistical models, providing additional noise robustness. The proposed method including both the long-term temporal and the static harmonic features led to considerable improvements under low SNR conditions, with 77.7% error reduction on average as compared with the ETSI AFE-VAD in our VAD testing. In addition, the word error rate was reduced by 29.1% in a test that included a full ASR system.
Predictive modeling of geometric deviations of 3D printed products - A unified modeling approach for cylindrical and polygon shapes (2014)

Geometric fidelity of 3D printed products is critical for Additive Manufacturing (AM) or 3D printing to be a direct manufacturing technology. Shape deviations of AM built products can be attributed to multiple variation sources such as substrate geometry defect, disturbance in process variables, and material phase change. Three strategies have been reported to improve geometric quality in AM: (1) control process variables x based on the observed disturbance of process variables Δx, (2) control process variables x based on the observed product deviation Δy, and (3) control input product geometry y based on the observed product deviation Δy. This study adopts the third strategy which changes the CAD design by optimally compensating the product deviations. To accomplish the goal an predictive model is desirable to forecast the quality of a wide class of product shapes, particularly considering the vast library of AM built products with complex geometry. Built upon our previous optimal compensation study of cylindrical products, this work aims at an unified modeling approach to predict the quality of both cylinder and polygon shapes. Experimental investigation of polygon shapes indicates the promise of predicting and compensating a wide class of products built through 3D printing technology.
New methods for positive selection of yeast ethanol overproducing mutants (2016)

Abstract Fuel ethanol is an environmentally friendly alternative liquid fuel to the widely used petroleum derived transportation liquid fuels. Since 2007, worldwide fuel ethanol production has increased. Currently ethanol is primarily produced from carbohydrates such as sucrose and starch by fermentation using the yeast Saccharomyces cerevisiae. In this work, new approaches for the selection of S. cerevisiae strains with increased ethanol production from hydrolyzed corn meal are described. An industrial production strain of Saccharomyces cerevisiae AS400 was subjected to positive selection of mutants resistant to toxic concentrations of oxythiamine, trehalose, 3-bromopyruvate, glyoxylic acid, and glucosamine. The selected mutants are characterized by 5-8% increase in ethanol yield (g g-1 of consumed glucose) as compared to the parental industrial ethanol-producing strain. A three-step selection approach that consisted of the use of glyoxylic acid, glucosamine and bromopyruvate resulted in a 12% increase in ethanol yield during fermentation on industrial media. These results indicate that the selected strains are promising candidates for industrial ethanol production.
A Novel Augmentation Strategy for Treating Resistant Major Depression (2001)

Olanzapine plus fluoxetine demonstrated superior efficacy for treating resistant depression compared to either agent alone.
Modified alternating current defibrillation: a new defibrillation technique (2008)

Modulated AC defibrillation is safe and effective as the commercially available DC defibrillation. The defibrillator is built from an inexpensive high-voltage transformer, without the need for capacitor, batteries, or routine maintenance, delivers repeated shock without any delay, and provides pacing as well. It may be an ideal platform for automatic home defibrillator.
Orthogonal functional basis neural network for functional approximation (2002)

Subset selection is a well-known technique for generating an efficient and effective neural network structure. The technique has been combined with regularization to improve the generalization performance of a neural network. In this paper, we show an incongruity involving subset selection and regularization. We present an approach to solve this dissonance wherein our subset selection is derived from a combination of functional basis. A more efficient training convergence speed is shown using the new basis which is derived from an 'orthogonal-functional-basis' transformation. With this transformation we propose a new orthogonal functional basis neural network structure which is not only more computationally tractable but also gives better generalization performance. Simulation studies are presented that demonstrate the performance, behavior, and advantages of the proposed network.
A North American study of adapalene-benzoyl peroxide combination gel in the treatment of acne. (2009)

A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% recently has been developed for the treatment of acne vulgaris. In this multicenter, randomized, double-blind, parallel-group, active- and vehicle-controlled study conducted at 60 centers in the United States, Puerto Rico, and Canada, we assessed the efficacy and safety of adapalene-BPO combination gel in comparison with adapalene and BPO monotherapies as well as the gel vehicle. Participants with moderate facial acne vulgaris (rated 3 on the 5-point investigator global assessment of acne severity scale) were recruited and randomized to receive once-daily treatment with adapalene-BPO combination gel, adapalene monotherapy, BPO monotherapy, or gel vehicle for 12 weeks. They were assessed for success rate (the percentage of participants with investigator global assessment of acne severity rated clear or almost clear) and percentage change in inflammatory lesion (IL), noninflammatory lesion (NIL), and total lesion counts. Of the 1668 participants enrolled, 1429 (85.7%) completed the study. At study end point, adapalene-BPO combination gel showed a significantly higher success rate (P < or = .006) and a greater percentage reduction in all acne lesion counts (P < or = .017) compared with the other treatment groups. A significant early treatment effect of adapalene-BPO combination gel at week 1 compared with adapalene monotherapy and vehicle also was observed for all lesion count reductions (P<.001). The safety of adapalene-BPO combination gel was comparable with adapalene and BPO monotherapies and vehicle. In a large clinical trial, the adapalene-BPO fixed-dose combination gel has shown superiority in efficacy compared with adapalene and BPO monotherapies and vehicle, with an early onset of efficacy and a good safety profile.
Imaging dynamic cellular events with quantum dots The bright future. (2010)

Semiconductor quantum dots (QDs) are tiny light-emitting particles that have emerged as a new class of fluorescent labels for biology and medicine. Compared with traditional fluorescent probes, QDs have unique optical and electronic properties such as size-tuneable light emission, narrow and symmetric emission spectra, and broad absorption spectra that enable the simultaneous excitation of multiple fluorescence colours.
Adaptive Primary Path Switching for SCTP Handover (2008)

This paper proposes a primary path switching scheme for SCTP handover, in which a mobile terminal switches its primary path to an alternate path adaptively by using the round trip times (RTTs) of the paths measured in the network. From the experiments we see that a conservative switching scheme is preferred in the network where the gap of RTTs of the candidate paths is small, whereas an aggressive scheme is reasonable in the network with a large gap of RTTs.
PREPARATION OF 3-CHLORO-6-(TRIPHENYLMETHYLAZO) PYRIDAZINE (1989)

(1989). PREPARATION OF 3-CHLORO-6-(TRIPHENYLMETHYLAZO) PYRIDAZINE. Organic Preparations and Procedures International: Vol. 21, No. 1, pp. 125-128.
Suggestion of Pipe Coupling Method for Maximum and Uniform Joining Stress (2006)

A new method of pipe joining using shape memory alloys (SMAs) is proposed in this study to obtain the maximum and uniform joining stress. Fe-based SMAs, regarded as potential alloys for pipe couplings, is not so widely industrialized as anticipated. The major obstacle is error of pipe size, which causes a gap between deformed SMA joint and pipes to be joined prior to heating. Since the recoverable strain of Fe SMAs is comparable to the gap, most of the strain is wasted as free recovery. In this study, the problem is settled by deforming simultaneously SMA coupling and pipes to be joined with the coupling inserted in the pipes. By doing so, there is always no gap between coupling and pipes prior to heating. The new method makes it possible to apply alloys with a poor shape memory effect (SME) to pipe couplings. Some other expected advantages and disadvantages will be discussed.
Alkaline Cellulases for Laundry Detergents: Production by Alkalophilic Strains of<i>Bacillus</i>and Some Properties of the Crude Enzymes (1990)

Journal Article Alkaline Cellulases for Laundry Detergents: Production by Alkalophilic Strains of Bacillus and Some Properties of the Crude Enzymes Get access Shitsuw Shikata, Shitsuw Shikata Tochigi Research Laboratories of Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-34, Japan Search for other works by this author on: Oxford Academic Google Scholar Katsuhisa Saeki, Katsuhisa Saeki Tochigi Research Laboratories of Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-34, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiromi Okoshi, Hiromi Okoshi Tochigi Research Laboratories of Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-34, Japan Search for other works by this author on: Oxford Academic Google Scholar Tadashi Yoshimatsu, Tadashi Yoshimatsu Tochigi Research Laboratories of Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-34, Japan Search for other works by this author on: Oxford Academic Google Scholar Katsuya Ozaki, Katsuya Ozaki Tochigi Research Laboratories of Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-34, Japan Search for other works by this author on: Oxford Academic Google Scholar Shuji Kawai, Shuji Kawai Tochigi Research Laboratories of Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-34, Japan Search for other works by this author on: Oxford Academic Google Scholar Susumu Ito Susumu Ito Tochigi Research Laboratories of Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-34, Japan To whom all correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 54, Issue 1, 1 January 1990, Pages 91–96, https://doi.org/10.1080/00021369.1990.10869922 Published: 01 January 1990 Article history Received: 27 July 1989 Published: 01 January 1990
Silica−Metal Core−Shells and Metal Shells Synthesized by Porphyrin-Assisted Photocatalysis (2008)

Uniform silica beads modified with a positively charged tin porphyrin (SnT(NMe4Py)P) adsorbed onto their surface are used as photocatalytically active templates to synthesize platinum and palladium shell and core−shell nanostructures. The cationic porphyrin SnT(NMe4Py)P serves a dual function, acting as both a photocatalyst to reduce metal ions and nucleate growth sites and as a surface modifier that promotes binding of platinum metal to the surface of the nanospheres. Hollow platinum nanoshells can then be produced by removing the silica cores using hydrofluoric acid. Magnetic silica−platinum core−shell spheres can also be prepared starting from silica spheres containing magnetite nanoparticles. The silica−porphyrin−platinum nanocomposites contain all the components necessary to produce hydrogen gas via a tin porphyrin-mediated reductive photocatalytic process using a sacrificial electron donor. However, due to instability of the SnT(NMe4Py)P, hydrogen production can only be realized when a degradation-resistant water-soluble tin porphyrin photocatalyst (SnTPPS) is added to a solution containing the nanocomposites and an electron donor.
Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. (1994)

Tumor necrosis factor (TNF) has been shown to bind two distinct receptors, designated p60 and p80, with high affinity, resulting, within minutes, in phosphorylation of several proteins. The receptors themselves do not exhibit protein kinase activity nor have any associated proteins been identified. We employed the glutathione-S-transferase (GST) fusion protein system consisting of the cytoplasmic domain of p60 (GST-p60CD delta 1) as a probe to help us identify receptor-associated proteins from human histiocytic lymphoma U-937 cells. We found that a protein of approximately 52 kDa (pp52) bound to GST-p60CD delta 1 from [35S]methionine- and 32P-labeled cells. The associated protein was phosphorylated on serine and threonine residues. Furthermore, we identified serine/threonine kinase activity associated with p60CD delta 1 that required either Mn2+ or Mg2+ for optimal activity. The preferred substrates for this kinase, in addition to p60CD delta 1, included casein and histone H1, but not histone H2B, myelin basic protein, enolase, or the cytoplasmic domain of p80. As was the case in U-937 cells, p60CD delta 1-associated kinase activity was also identified in human breast adenocarcinoma MCF-7 cells and human foreskin fibroblasts. TNF stimulation of MCF-7 and foreskin fibroblasts for 5-15 min induced approximately 50 and 240% increases in phosphorylation of p60CD delta 1, respectively. Thus, our results provide the first evidence for protein kinase activity that is specifically associated with the cytoplasmic domain of the p60 form of the TNF receptor and causes its phosphorylation. This p60 TNF receptor-associated protein and the associated kinase described here are referred to as p60-TRAP and p60-TRAK, respectively.
Meta-data indexing for XPath location steps (2006)

XML is the de facto standard for data representation and exchange over the Web. Given the diversity of the information available in XML, it is very useful to annotate XML data with a wide variety of meta-data, such as quality and sensitivity. When querying such XML data, say using XPath, it is important to efficiently identify the data that meet specified constraints on the meta-data. For example, different users may be satisfied with different levels of quality guarantees, or may only have access to different parts of the XML data based on specified security policies. In this paper, we address the problem of efficiently identifying the XML elements along a location step in an XPath query, that satisfy meta-data range constraints, when the meta-data levels are specifically drawn from an ordered domain (e.g., accuracy in [0,1], recency using timestamps, multi-level security, etc.). More specifically, we develop a family of index structures, which we refer to as meta-data indexes, to address this problem. A meta-data index is easily instantiated using a multi-dimensional index structure, such as an R-tree, incorporating novel query and update algorithms. We show that the full meta-data index (FMI), based on associating each XML element with its meta-data level, has a very high update cost for modifying an element's meta-data level. We resolve this problem by designing the inheritance meta-data index (IMI), in which (i) actual meta-data levels are associated only with elements for which this value is explicitly specified, and (ii) inherited meta-data levels and inheritance source nodes are associated with non-leaf nodes of the index structure. We design efficient query (for all XPath axes) and update (of meta-data levels) algorithms for the IMI, and experimentally demonstrate the superiority of the IMI over the FMI using benchmark data sets.
Spectrum handoffs with mixed-priority queueing model over Cognitive Radio Networks (2013)

In this paper, we propose a mixed preemptive and non-preemptive resume priority (PRP/NPRP) M/G/1 queueing model for the modeling of the traffic in Cognitive Radio (CR) Networks with prioritized transmissions. A traffic-adaptive spectrum handoff scheme is then developed based on the proposed queueing model for delay sensitive applications. This spectrum handoff scheme reduces the delivery time of the delay-sensitive applications for secondary users (SUs) while ensuring the overall performance of the network by avoiding overly frequent spectrum handoff between SUs. In the experiment section, we compare with two recently proposed queueing models using the traffic-adaptive spectrum handoff scheme and show the superior performance of the proposed approach.