gebhart/patrepeval huggingface dataset:
Nonsteroidal anti-inflammatory drugs (NSAIDs) or EP4 receptor antagonism enhances hematopoietic stem and progenitor cell (HSPC) mobilization and facilitates faster hematopoietic recovery after myeloablation. (2010)

6604 Background: We recently reported that Prostaglandin E2 (PGE2) increases homing and engraftment of HSPC to bone marrow (Hoggatt et al, Blood 2009). We hypothesized that blocking PGE2 synthesis via inhibition of cyclooxygenases (COX) by NSAIDs would facilitate HSPC mobilization and serve as an adjunct to current mobilization regimens. Methods: Mice were treated with filgrastim (Neupogen) (FG) with or without co-administration of NSAID or specific agonists and antagonists of PGE2 receptors (EP1-4). HSPC mobilized to peripheral blood were quantitated by colony forming units-granulocyte/macrophage (CFU-GM), by flow cytometry, or in competitive transplantation assays. In addtion, to confirm in a non-human primate model, 4 baboons were mobilized with FG ± NSAID in a crossover protocol. Results: Treatment of mice with NSAID + FG resulted in an increase in CFU-GM over FG alone (1.96 ± 0.19 fold, p < 0.001). NSAID synergistically enhanced mobilization by plerixafor (Mozobil) alone or with GROβ, indicating FG-independent mechanisms. In baboons, NSAID increased CFU-GM (2,845 vs. 5,975, p = 0.03) and CD34+ cells (9,051 vs. 2,6910, p = 0.03) per ml blood. Lethally irradiated mice transplanted with FG + NSAID mobilized grafts exhibited faster recovery of both neutrophils and platelets, with an increase in competitive repopulating units, indicating long-term repopulating cells were mobilized. EP4 antagonists significantly enhanced mobilization (2.02 ± 0.21 fold, p < 0.005), while an EP1-3 antagonist had no effect. Similarly, an EP4 agonist abrogated NSAID enhancement, while EP1-3 agonists did not, indicating that a lack of EP4 receptor signaling is responsible for enhanced HSPC mobilization. Conclusions: Our results define a novel role for NSAIDs and suggest that addition of NSAIDs, particularly Meloxicam, to current mobilization regimens may increase HSPC yield. In addition, we have identified novel mechanisms mediated by EP receptors and show that mobilization can be enhanced through antagonism of the EP4 receptor, defining a new pharmaceutical target for hematopoietic mobilization and transplantation. No significant financial relationships to disclose.
Homodyne detection applied tobit-oriented holographic memories (2005)

~~~~~~ ~~~~~~~~~679,8 679,9 680 680,1 680,2 680,3 680,4 680,5 enhanced bya factor 100withhomodynedetection 7,elength (nm) compared toconventional approach, homodyne detectionFigure 2 lock-in signal atfrequency c inpercent ofthe being allthemoreinteresting thanthediffracted signal is dcconentvsotal wavelenth weak, that isonissmall inthepresent case. Inconclusion, homodyne detection seemsparticularly adapted toincrease thedatatransfer rates ofbit-oriented holographic memories.
Receiver and transmitter iterative optimization using maximum sum-rate criterion for Multi-User MIMO systems (2010)

In this paper we present a new practical method for sum-rate maximization for a Multi-User MIMO system. Through this work, we first establish a general formula for the optimal receiver derived from the sum-rate expression called MSR (Maximum Sum Rate) receiver. The obtained MSR receiver is a linear function of the used linear transmitter. In a second step, we introduce this receiver in an iterative algorithm to derive the corresponding precoder. The proposed iterative algorithm is based on optimizing the MSR receiver for the receiving part and an SJNR (Signal to Jamming plus Interference Ratio) precoder at the transmitter. Simulation results are compared to two multi-user schemes among the existing ones. The first comparison is done with the closed form SJNR algorithm given in and the second one is done with an iterative scheme based on an MMSE receiver and an MMSE precoder given in. These comparisons highlight the gains obtained from both the MSR receiver structure and our iterative procedure.
Alkoxyamines: Toward a New Family of Theranostic Agents against Cancer (2014)

Theranostics combines therapeutic and diagnostic or drug deposition monitoring abilities of suitable molecules. Here we describe the first steps of building an alkoxyamine-based theranostic agent against cancer. The labile alkoxyamine ALK-1 (t(1/2) = 50 min at 37 °C) cleaves spontaneously to generate (1) a highly reactive free alkyl radical used as therapeutic agents to induce cell damages leading to cell death and (2) a stable nitroxide used as contrast agent for Overhauser-enhanced magnetic resonance imaging (OMRI). The ALK-1 toxicity was studied extensively in vitro on the glioblastoma cell line U87-MG. Cell viability appeared to be dependent on ALK-1 concentration and on the time of the observation following alkoxyamine treatment. For instance, the LC50 at 72 h was 250 μM. Data showed that cell toxicity was specifically due to the in situ released alkyl radical. This radical induced oxidative stress, mitochondrial changes, and ultimately the U87 cell apoptosis. The nitroxide production, during the alkoxyamine homolysis, was monitored by OMRI, showing a progressive MRI signal enhancement to 6-fold concomitant to the ALK-1 homolysis. In conclusion, we have demonstrated for the first time that the alkoxyamines are promising molecules to build theranostic tools against solid tumors.
Abstract 2023: Artemisinins enhanced the antileukemic efficacy of BCL2 inhibitors (2017)

Abstract More effective, less toxic treatments are needed to improve longevity and quality of life for patients with acute leukemias. Artesunate (AS), the current WHO-recommended drug for severe malaria, is a semi-synthetic derivative of the natural compound Artemisinin. AS has broad antineoplastic activity in vitro, and is well tolerated, inexpensive, and can be parenterally or orally administered in humans. Both AS and a more potent synthetic derivative, artemisinin-derived trioxane diphenylphosphate dimer 838 (ART-838), substantially inhibited acute leukemia growth in vivo and in vitro, at doses where normal CD34+ hematopoietic stem-progenitor cell clonogenicity was essentially unaffected. Moreover, AS and ART-838 synergized with several current antileukemic drugs (Fox et al, Oncotarget, 2015). To identify additional potential antileukemic drug combinations, we screened for the growth inhibitory effects of AS and ART-838 against 3 acute leukemia cell lines co-treated with a panel of 122 antileukemic compounds (mainly emerging antineoplastic drugs). Both AS and ART-838 showed synergistic or additive growth inhibition with several compounds. Two BCL2 protein family inhibitors demonstrated among the highest levels of synergy. One of these, ABT-199 (venetoclax), was recently approved by the FDA for the treatment of chronic lymphocytic leukemia (CLL) and received breakthrough designation for acute myeloid leukemia (AML). Therefore, we decided to further investigate the combination of ABT-199 with AS or ART-838. Synergy between AS (or ART-838) and ABT-199 was confirmed across several acute leukemia cell lines with varying sensitivities to each drug. Both leukemia cell proliferation and survival were affected synergistically by exposure to the combination of AS (or ART-838) plus ABT-199. Utilizing in vivo imaging, we assessed changes in growth kinetics of tail vein-injected acute leukemia cell lines and primary patient-derived samples constitutively expressing luciferase in mice treated with AS, ABT-199, or the combination. The combination of AS plus ABT-199 had the greatest antileukemic effect. Based on these data, we propose that Artemisinins plus BCL2 inhibitors comprise an antileukemic drug pair with high potential for incorporation into acute leukemia therapeutic regimens. Citation Format: Blake S. Moses, Jennifer M. Fox, Xiaochun Chen, Jeffrey W. Tyner, Gary H. Posner, Patrick Bailey, Curt I. Civin. Artemisinins enhanced the antileukemic efficacy of BCL2 inhibitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2023. doi:10.1158/1538-7445.AM2017-2023
Deep Neural Network for Structural Prediction and Lane Detection in Traffic Scene (2016)

Hierarchical neural networks have been shown to be effective in learning representative image features and recognizing object classes. However, most existing networks combine the low/middle level cues for classification without accounting for any spatial structures. For applications such as understanding a scene, how the visual cues are spatially distributed in an image becomes essential for successful analysis. This paper extends the framework of deep neural networks by accounting for the structural cues in the visual signals. In particular, two kinds of neural networks have been proposed. First, we develop a multitask deep convolutional network, which simultaneously detects the presence of the target and the geometric attributes (location and orientation) of the target with respect to the region of interest. Second, a recurrent neuron layer is adopted for structured visual detection. The recurrent neurons can deal with the spatial distribution of visible cues belonging to an object whose shape or structure is difficult to explicitly define. Both the networks are demonstrated by the practical task of detecting lane boundaries in traffic scenes. The multitask convolutional neural network provides auxiliary geometric information to help the subsequent modeling of the given lane structures. The recurrent neural network automatically detects lane boundaries, including those areas containing no marks, without any explicit prior knowledge or secondary modeling.
Table S5 from PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers (2023)

<p>Effects of Systemic Administration of Free Payload Compared with Conventional HER2-vc0101 on Indicators of Bone Marrow Toxicity and Bone Marrow Payload Levels in Rats</p>
A PV ramp-rate control strategy to extend battery lifespan using forecasting (2022)

This study analyses and presents a new ramp-rate control algorithm for smoothing PV power fluctuations, designed to address three fundamental objectives: to reduce battery cycling, to meet minimum storage requirements and to be able to operate, without ramp-rate violations, with real publicly-available forecasting. The algorithm was compared to three benchmark methods and, as a performance limit, also to a hypothetical perfect prediction. Different performance variables were analyzed for all the strategies within a restricted ramp-rate constraint (2%/min): minimum storage requirement, battery power distributions, throughput energy, state of charge (SOC) distributions, degradation (calendar and cycling), expected battery lifespan and levelized cost of energy (LCOE). The proposal proves to be the most cost-effective smoothing technique and the simulation results show that its performance is comparable to the obtained with the use of an assumed perfect prediction.
Complex query decorrelation (2002)

Complex queries used in decision support applications use multiple correlated subqueries and table expressions, possibly across several levels of nesting. It is usually inefficient to directly execute a correlated query; consequently, algorithms have been proposed to decorrelate the query, i.e. to eliminate the correlation by rewriting the query. This paper explains the issues involved in decorrelation, and surveys existing algorithms. It presents an efficient and flexible algorithm called magic decorrelation which is superior to existing algorithms both in terms of the generality of application, and the efficiency of the rewritten query. The algorithm is described in the context of its implementation in the Starburst Extensible Database System, and its performance is compared with other decorrelation techniques. The paper also explains why magic decorrelation is not merely applicable, but crucial in a parallel database system.
Stabilization of Liquid Foams through the Synergistic Action of Particles and an Immiscible Liquid (2014)

Liquid foams are familiar from beer, frothed milk, or bubble baths; foams in general also play important roles in oil recovery, lightweight packaging, and insulation. Here a new class of foams is reported, obtained by frothing a suspension of colloidal particles in the presence of a small amount of an immiscible secondary liquid. A unique aspect of these foams, termed capillary foams, is the particle-mediated spreading of the minority liquid around the gas bubbles. The resulting mixed particle/liquid coating can stabilize bubbles against coalescence even when the particles alone cannot. The coated bubbles are further immobilized by entrapment in a network of excess particles connected by bridges of the minority liquid. Capillary foams were prepared with a diverse set of particle/liquid combinations to demonstrate the generality of the phenomenon. The observed foam stability correlates with the particle affinity for the liquid interface formed by spreading the minority liquid at the bubble surface.
Blue phase liquid crystals induced by bent-shaped molecules based on 1,3,4-oxadiazole derivatives (2011)

Abstract Five bent-shaped molecules derived from the 1,3,4-oxadiazole core are synthesised and doped into chiral nematic liquid crystals to induce the blue phase. The effects of their terminal chain length on the blue phase range are compared and analysed experimentally. The results show that the blue phase range is significantly influenced by terminal chain length, and the widest range could be obtained in the case that the chain length is neither too long nor too short. In addition, it is also found that the mechanism of a blue phase induced by bent-shaped molecules is mainly related with its geometry, no matter whether a liquid crystal phase exists or not. Keywords: blue phaseliquid crystaloxadiazole Acknowledgements This work was supported by the National Science Foundation of China (grant No. 60878047 No. 61108065), the Fundamental Research Funds for the Central Universities (grant No. WM1014015) and the Research Foundations of ECUST (grant No. yk0157125).
Lifestyles in transition: evolution and natural history of the genus Lactobacillus (2017)

Lactobacillus species are found in nutrient-rich habitats associated with food, feed, plants, animals and humans. Due to their economic importance, the metabolism, genetics and phylogeny of lactobacilli have been extensively studied. However, past research primarily examined lactobacilli in experimental settings abstracted from any natural history, and the ecological context in which these bacteria exist and evolve has received less attention. In this review, we synthesize phylogenetic, genomic and metabolic metadata of the Lactobacillus genus with findings from fine-scale phylogenetic and functional analyses of representative species to elucidate the evolution and natural history of its members. The available evidence indicates a high level of niche conservatism within the well-supported phylogenetic groups within the genus, with lifestyles ranging from free-living to strictly symbiotic. The findings are consistent with a model in which host-adapted Lactobacillus lineages evolved from free-living ancestors, with present-day species displaying substantial variations in terms of the reliance on environmental niches and the degree of host specificity. This model can provide a framework for the elucidation of the natural and evolutionary history of Lactobacillus species and valuable information to improve the use of this important genus in industrial and therapeutic applications.
Secure spontaneous emergency access to personal health record (2011)

We propose a system which enables access to the user's Personal Health Record (PHR) in the event of emergency. The\naccess typically occurs in an ad-hoc and spontaneous manner and the user is usually unconscious, hence rendering the\nunavailability of the user's password to access the PHR. The\nproposed system includes a smart card carried by the user\nat all time and it is personalized with a pseudo secret, an\nURL to the PHR Server, a secret key shared with the PHR\nServer and a number of redemption tokens generated using\na hash chain. In each emergency session, a one-time use\nredemption token is issued by the smart card, allowing the\nemergency doctor to retrieve the user's PHR upon successful authentication of his credentials and validation of the\nredemption token. The server returns the PHR encrypted\nwith a one-time session key which can only be decrypted by\nthe emergency doctor. The devised interaction protocol to\nfacilitate emergency access to the user's PHR is secure and\nefficient.
In situ X-ray-assisted electron microscopy staining for large biological samples (2022)

Electron microscopy of biological tissue has recently seen an unprecedented increase in imaging throughput moving the ultrastructural analysis of large tissue blocks such as whole brains into the realm of the feasible. However, homogeneous, high-quality electron microscopy staining of large biological samples is still a major challenge. To date, assessing the staining quality in electron microscopy requires running a sample through the entire staining protocol end-to-end, which can take weeks or even months for large samples, rendering protocol optimization for such samples to be inefficient. Here, we present an in situ time-lapsed X-ray-assisted staining procedure that opens the 'black box' of electron microscopy staining and allows observation of individual staining steps in real time. Using this novel method, we measured the accumulation of heavy metals in large tissue samples immersed in different staining solutions. We show that the measured accumulation of osmium in fixed tissue obeys empirically a quadratic dependence between the incubation time and sample size. We found that potassium ferrocyanide, a classic reducing agent for osmium tetroxide, clears the tissue after osmium staining and that the tissue expands in osmium tetroxide solution, but shrinks in potassium ferrocyanide reduced osmium solution. X-ray-assisted staining gave access to the in situ staining kinetics and allowed us to develop a diffusion-reaction-advection model that accurately simulates the measured accumulation of osmium in tissue. These are first steps towards <i>in silico</i> staining experiments and simulation-guided optimization of staining protocols for large samples. Hence, X-ray-assisted staining will be a useful tool for the development of reliable staining procedures for large samples such as entire brains of mice, monkeys, or humans.
Broadband and Ultrahigh Resolution Optical Spectroscopy using a Tapered Fiber (2014)

We introduce a new integrated-optics spectroscopy scheme based on multimode interference, achieving ultra-high resolving powers (Q > 105) with linewidths down to 10 pm at 1500 nm, and a broad spectroscopy range from 500 nm to 1600 nm within a monolithic, millimeter-scale device.
Whole brain inhomogeneous magnetization transfer (ihMT) imaging: Sensitivity enhancement within a steady‐state gradient echo sequence (2017)

The proposed sensitivity-boosted and time-efficient steady-state ihMT-gradient echo sequence, implemented and optimized at 1.5T, allowed robust high-resolution 3D ihMT imaging of the whole brain within a clinically compatible scan time. Magn Reson Med 79:2607-2619, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Epidermal Acidification and Skin Barrier Optimization in the Management of Atopic Dermatitis (2016)

ABSTRACT The importance of the epidermal acid mantle in maintaining the natural flora of the skin and its role in skin barrier homeostasis has been known for decades. Despite well-established evidence that the skin barrier pH is elevated in patients with inflammatory dermatoses such as atopic dermatitis, epidermal pH modification has been an underexplored therapeutic option that could potentially prevent overuse of antibiotics, topical glucocorticoids, and immune modulators. By optimizing the skin using a novel therapeutic regimen, we report three cases of recalcitrant atopic dermatitis that were successfully treated based on the concept of epidermal acidification combined with optimization of the skin barrier.
[MARS] a real time motion capture and muscle fatigue monitoring tool (2012)

Incorrect muscle usage and muscle fatigue are a leading cause of many sports injures. As a result, sensing and monitoring muscles, as well as human motion, is important. Toward this end, we present the Muscle Activity Recognition System (MARS) system. MARS utilizes a system of small inertial sensors to deduce body motion and muscle fatigue. In this demo we demonstrate how MARS' sensors, placed on the major muscles of the lower body (hamstrings, quadriceps, calves), are used for motion capture and muscle fatigue determination. The system uses an animated human body model to display the motion of the subject, and highlight using different colors, the fatigue status of the muscles in use.
SYNTHESIS AND ADENOSINE RECEPTOR AFFINITY AND POTENCY OF 8-ALKYNYL DERIVATIVES OF ADENOSINE (2001)

Adenosine derivatives bearing different (ar)alkynyl chains at the 8-position were synthesized and tested at human adenosine receptors. Binding studies showed that all compounds possess affinity for the A3 subtype in the high nM range. Moreover, guanosine 5'-O-(3-[35S]thio)triphosphate binding assay indicated that the 8-alkynyl adenosines behaved as antagonists of NECA at A3 receptors.
Interfacial Tension (IFT) and Surface Alteration Interplay (2012)

Abstract The two main parameters required to assess an enhanced oil recovery (EOR) technique in terms of its efficiency are interfacial tension and surface (wettability) alteration. The impact of these parameters on recovering what is left in the reservoir is crucial. With the current interest in brine injection as a potential-EOR method, the role of IFT and wettability alteration needs better understanding. In this study, a theoretical model is developed to evaluate the impact of both parameters. The results of this study indicate that salinity injection affects more surface wettability rather than interfacial tension. Conventional techniques of contact angle measurements on reservoir rocks at downhole conditions are very complicated. They are highly sensitive and require good core preservation and preparation. We propose a protocol to measure contact angle dependence on brine salinity, which includes a single contact measurement in rock/brine/oil system using fresh water and a set of less complicated measurements in brine/oil and rock/brine/air systems. The results of our predictive protocol for contact angle measurements are in very good agreement with conventional experimental measurements using glass/brine/dodecane system. The fact that simple contact angle measurements on the surface in air are required to calculate contact angles at different salinities makes the utilization of this protocol very attractive and less sensitive to surface preparation and its complexity.
Rank modulation with multiplicity (2010)

Rank modulation is a scheme that uses the relative order of cell levels to represent data. Its applications include flash memories, phase-change memories, etc. An extension of rank modulation is studied in this paper, where multiple cells can have the same rank. We focus on the rewriting of data based on this new scheme, and study its basic properties.