gebhart/patrepeval huggingface dataset:
Radiolabeled cetuximab: Dose optimization for epidermal growth factor receptor imaging in a head‐and‐neck squamous cell carcinoma model (2010)

Noninvasive imaging of the epidermal growth factor receptor (EGFR) in head-and-neck squamous cell carcinoma could be of value to select patients for EGFR-targeted therapy. We assessed dose optimization of (111) Indium-DTPA-cetuximab ((111) In-cetuximab) for EGFR imaging in a head-and-neck squamous cell carcinoma xenograft model. (111) In-cetuximab slowly internalized into FaDu cells in vitro, amounting to 1.0 × 10(4) molecules cetuximab per cell after 24 hr (15.8% of added activity). In nude mice with subcutaneous FaDu xenograft tumors, a protein dose escalation study with (111) In-cetuximab showed highest specific accumulation in tumors at protein doses between 1 and 30 μg per mouse (mean tumor uptake 33.1 ± 3.1%ID/g, 3 days postinjection (p.i.)). The biodistribution of (111) In-cetuximab and (125) I-cetuximab was determined at 1, 3 and 7 days p.i. at optimal protein dose. Tumor uptake was favorable for (111) In-cetuximab compared to (125) I-cetuximab. With pixel-by-pixel analysis, good correlations were found between intratumoral distribution of (111) In-cetuximab as determined by autoradiography and EGFR expression in the same tumor sections as determined immunohistochemically (mean r = 0.74 ± 0.14; all correlations p < 0.0001). Micro Single Photon Emission Computed Tomography (MicroSPECT) scans clearly visualized FaDu tumors from 1 day p.i. onward and tumor-to-background contrast increased until 7 days p.i. (tumor-to-liver ratios 0.58 ± 0.24, 3.42 ± 0.66, 8.99 ± 4.66 and 16.33 ± 11.56, at day 0, day 1, day 3 and day 7 p.i., respectively). Our study suggests that, at optimal cetuximab imaging dose, (111) In-cetuximab can be used for visualization of EGFR expression in head-and-neck squamous cell carcinoma using SPECT.
ChemInform Abstract: CONJUGATE ADDITION REACTIONS OF α,β‐UNSATURATED ESTERS WITH HIGHER ORDER CUPRATES (1983)

Abstract Die Li‐cuprate (II) bzw. (V) werden mit ungesättigten Estern (I), (VI), (VIII) und (XI) zu entsprechenden Addukten bzw. Adduktgemischen umgesetzt.
Wind Power in Power Systems (2005)

As environmental concerns have focussed attention on the generation of electricity from clean and renewable sources, wind energy has become the world's fastest growing energy source. The authors dr ...
A high-power GaAlAs superluminescent diode with an anti-reflective window structure (1990)

A high Power (>50mW) GaAlAs superluminescent diode is experimentally demonstrated in which an anti-reflective window structure is incorporated to the conventional high power laser diode.
Synthesis, Structure, and Properties of Compounds in the NaHSO<sub>4</sub>−CsHSO<sub>4</sub> System. 2. The Absence of Superprotonic Transitions in Cs<sub>2</sub>Na(HSO<sub>4</sub>)<sub>3</sub> and CsNa<sub>2</sub>(HSO<sub>4</sub>)<sub>3</sub> (2001)

Exploratory synthesis in the NaHSO4−CsHSO4 system, aimed at discovering novel proton-conducting solids, yielded the new compounds CsNa2(HSO4)3 and Cs2Na(HSO4)3. Thermal analysis demonstrated the absence of phase transitions for both compounds prior to melting. The conductivities of the two compounds vary monotonically with temperature, in a non-Arrhenius manner, from ambient to the respective melt temperatures of 398 and 413 K. At 363 K the conductivities are on the order of 10-8 Ω1-cm-1, which is comparable to that of other alkali acid sulfates. The absence of transitions to disordered, high conductivity phases, as is observed in compounds such as CsHSO4, is explained in terms of the stiffness of the Na−O bonds, which may serve to prevent rapid reorientation of SO4 tetrahedral groups.
The Prolonged Anticonvulsant Action of Taurine on Genetically Determined Seizure-Susceptibility (1978)

SUMMARY: A prolonged anticonvulsant action of taurine has been shown in a strain of seizure susceptible rats. The audiogenic rat (AS) has lower intracerebral electroshock thresholds in three auditory nuclei; the ventral cochlear, the inferior colliculi and the medial geniculate, and in one nonauditory structure; the reticular formation, than a strain of nonaudiogenic rats (NAS). Furthermore, the AS animals routinely display maximal (tonic-clonic) convulsion, regardless of brain structure stimulated, whereas NAS subjects respond with minimal (clonic) convulsions. Within three minutes of intraventricular injection of 8 μ moles, taurine reduces the susceptibility of AS rats to intracerebral electroshock seizures along with attenuation of the severity of the convulsion. The initial elevation in intracerebral electroshock threshold returns to pretreatment value at 24 hours, only to rise again at 48 hours and to remain elevated through day six after injection. In contrast, the severity of convulsions remains attenuated through 24 hours, after which it returns to pre-injection level. By comparison, NAS animals injected intracerebroventricularly in an identical fashion to the AS rats showed no changes in either seizure threshold or severity of convulsion. The direct injection of 200n-moles of taurine in the inferior colliculi of AS rats produced a slow developing, but prolonged, elevation of intracerebral electroshock threshold of this auditory nuclei. However, at no time after the intracerebral injection of taurine was convulsive severity changed. Injection of taurine into the inferior colliculi of NAS subjects did not change either susceptibility or severity of intracerebral electroshock seizures. The data indicate that taurine produces an anticonvulsant effect which is slow in onset, potent, selective and prolonged.
The ULTRAVIS system (2000)

Article Free Access Share on The ULTRAVIS system Author: Gunter Knittel Hewlett-Packard Laboratories, Visual Computing Department Hewlett-Packard Laboratories, Visual Computing DepartmentView Profile Authors Info & Claims VVS '00: Proceedings of the 2000 IEEE symposium on Volume visualizationOctober 2000 Pages 71–79https://doi.org/10.1145/353888.353901Published:09 October 2000Publication History 16citation376DownloadsMetricsTotal Citations16Total Downloads376Last 12 Months15Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Neuroprotective mechanism of modafinil on Parkinson disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. (2004)

The anti-oxidation and the modulation of nigrostriatal GABA and striatal NA and 5-HT release contributed to the neuroprotective effects of modafinil on PD induced by MPTP.
Automated surgical step recognition in normalized cataract surgery videos (2014)

Huge amounts of surgical data are recorded during video-monitored surgery. Content-based video retrieval systems intent to reuse those data for computer-aided surgery. In this paper, we focus on real-time recognition of cataract surgery steps: the goal is to retrieve from a database surgery videos that were recorded during the same surgery step. The proposed system relies on motion features for video characterization. Motion features are usually impacted by eye motion or zoom level variations, which are not necessarily relevant for surgery step recognition. Those problems certainly limit the performance of the retrieval system. We therefore propose to refine motion feature extraction by applying pre-processing steps based on a novel pupil center and scale tracking method. Those pre-processing steps are evaluated for two different motion features. In this paper, a similarity measure adapted from Piciarelli's video surveillance system is evaluated for the first time in a surgery dataset. This similarity measure provides good results and for both motion features, the proposed preprocessing steps improved the retrieval performance of the system significantly.
Blends of Linear and Long-Chain Branched Poly(<scp>l</scp>-lactide)s with High Melt Strength and Fast Crystallization Rate (2012)

The long-chain branched polylactides (LCB-PLAs) prepared by coupling the hydroxyl-terminated two-arm (linear) and triarm PLA prepolymers of identical arm length with hexamethylenediacianate (HDI) were used to improve the melt rheological and crystallization properties of linear polylactide resin, PLA 4032D from NatureWorks. The blends containing LCB-PLA displayed higher zero shear viscosities, more significant shear shinning, more melt elasticity, and much longer relaxation times together with significant strain hardening in elongational deformation. Tg, Tm and crystallinity (Xc) of linear PLA remained virtually unaffected, but the crystallization rate increased obviously, since the branch points of LCB-PLAs could play a role of nucleating agent. High melt strength, fast crystallization, and favorable miscibility improved the foaming ability of the linear/LCB-PLA blends, substantially.
Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas (2013)

The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular EBV strains account for this phenomenon. We report that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), shows remarkable similarity to other NPC viruses but is divergent from all other known strains. M81 exhibited a reversed tropism relative to common strains with a reduced ability to infect B cells and a high propensity to infect epithelial cells, which is in agreement with its isolation from carcinomas. M81 spontaneously replicated in B cells in vitro and in vivo at unusually high levels, in line with the enhanced viral replication observed in NPC patients. Spontaneous replication and epitheliotropism could be partly ascribed to polymorphisms within viral proteins. We suggest considering M81 and its closely related isolates as an EBV subtype with enhanced pathogenic potential.
Bactericidal/permeability-increasing protein and cathepsin G are the major antigenic targets of antineutrophil cytoplasmic autoantibodies in systemic sclerosis. (2003)

BPI and cathepsin G are the major antigenic targets of ANCA seen in patients with SSc. Patients with antibodies to BPI had lower skin scores.
Dehydrogenation of indolines to indoles via azasulphonium salts or N-chloramines (1984)

The dehydrogenation of indolines to indoles without using mineral oxidising reagents is described. The conversion was achieved via either azasulphonium salts or N-chloramines, the former route involving milder conditions but a more complex procedure.
Regiodivergent radical oxidative coupling of vinyl ethers with dithiane by copper or iron catalysis (2017)

Direct regioselective C–H dithioacetalization of readily available vinyl ethers to yield a variety of substituted dithianes under a copper or iron catalysis has been developed.
ChemInform Abstract: Synthesis of Perovskite‐Type (La1‐xSrx)MnO3 (0 ≤ x ≤ 0.3) at Low Temperature. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Site-Directed Mutagenesis of Loop L3 of Sucrose Porin ScrY Leads to Changes in Substrate Selectivity (1999)

The difference in substrate selectivity of the maltodextrin (LamB) and sucrose (ScrY) porins is attributed mainly to differences in loop L3, which is supposed to constrict the lumen of the pores. We show that even a single mutation (D201Y) in loop L3 leads to a narrowing of the substrate range of ScrY to that resembling LamB. In addition, we removed the putative N-terminal coiled-coil structure of ScrY and studied the effect of this deletion on sucrose transport.
Named entity recognition of follow-up and time information in 20 000 radiology reports (2012)

The experiments demonstrate that the system performs far better than a baseline rule-based system and is worth considering for deployment trials in an alert generation system. The LSP classifier successfully compensated for the inherent weakness of CRF, that is, its inability to use global information.
Rhodium(<scp>i</scp>) complexes with N-heterocyclic carbenes bearing a 2,3,4,5-tetraphenylphenyl and its higher dendritic frameworks (2006)

Novel rhodium(I) complexes with N-heterocyclic carbenes bearing a 2,3,4,5-tetraphenylphenyl and its higher dendritic frameworks were synthesized and the complexes were used as catalysts in rhodium-catalyzed hydrosilylation of alpha,beta-unsaturated ketones to show high 1,4-adduct selectivity.
Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Shown by a Comprehensive Analysis of the CCN Family Proteins in Cartilage (2008)

CCN2 is best known as a promoter of chondrocyte differentiation among the CCN family members, and its null mice display skeletal dysmorphisms. However, little is known concerning roles of the other CCN members in chondrocytes. Using both in vivo and in vitro approaches, we conducted a comparative analysis of CCN2-null and wildtype mice to study the roles of CCN2 and the other CCN proteins in cartilage development. Immunohistochemistry was used to evaluate the localization of CCN proteins and other chondrocyte-associated molecules in the two types of mice. Moreover, gene expression levels and the effects of exogenous CCN proteins on chondrocyte proliferation, differentiation, and the expression of chondrocyte-associated genes in their primary chondrocytes were evaluated. Ccn3 was dramatically upregulated in CCN2-null cartilage and chondrocytes. This upregulation was associated with diminished cell proliferation and delayed differentiation. Consistent with the in vivo findings, CCN2 deletion entirely retarded chondrocyte terminal differentiation and decreased the expression of several chondrocyte-associated genes in vitro, whereas Ccn3 expression drastically increased. In contrast, the addition of exogenous CCN2 promoted differentiation strongly and induced the expression of the associated genes, whereas decreasing the Ccn3 expression. These findings collectively indicate that CCN2 induces chondrocyte differentiation by regulating the expression of chondrocyte-associated genes but that these effects are counteracted by CCN3. The lack of CCN2 caused upregulation of CCN3 in CCN2-null mice, which resulted in the observed phenotypes, such as the resultant delay of terminal differentiation. The involvement of the PTHrP-Ihh loop in the regulation of CCN3 expression is also suggested.
Automated extraction of chemical synthesis actions from experimental procedures (2020)

Experimental procedures for chemical synthesis are commonly reported in prose in patents or in the scientific literature. The extraction of the details necessary to reproduce and validate a synthesis in a chemical laboratory is often a tedious task requiring extensive human intervention. We present a method to convert unstructured experimental procedures written in English to structured synthetic steps (action sequences) reflecting all the operations needed to successfully conduct the corresponding chemical reactions. To achieve this, we design a set of synthesis actions with predefined properties and a deep-learning sequence to sequence model based on the transformer architecture to convert experimental procedures to action sequences. The model is pretrained on vast amounts of data generated automatically with a custom rule-based natural language processing approach and refined on manually annotated samples. Predictions on our test set result in a perfect (100%) match of the action sequence for 60.8% of sentences, a 90% match for 71.3% of sentences, and a 75% match for 82.4% of sentences.
Thermocurable polymers as resists for imprint lithography (2000)

In nanoimprint lithography, high pressures are utilised for embossing thermoplastics. This may introduce mechanical strain in the mould and the sample. By using a thermocurable polymer (polydimethylsiloxane, PDMS), a low pressure imprint process, working at pressures of < 0.2 MPa, has proven viable. The new process may drastically reduce the thermal budget and the mechanical load in imprint lithography.
Impairment by Heparin of Primary Haemostasis and Platelet [<sup>14</sup>C]5‐Hydroxytryptamine Release (1977)

Heparin was administered to 34 normal subjects by intravenous injection (100 u/kg) and the template bleeding time was significantly increased both 10 min and 120 min following injection. Before heparin the bleeding time was 5.3±1.0 min (mean±1 SD); 10 min after injection it was 9.8±5.6 min ( P <0.001); and 120 min after injection it was 7.2±3.9 min ( P <0.001). Increases in the bleeding time were unrelated to changes in platelet count, and independent of heparin's effect on plasma coagulation. In blood drawn 10 min and 120 min following heparin injection, there was significantly less [ 14 C]5‐HT released from platelet‐rich plasma (PRP) in response to collagen, 0.41 mM epinephrine and 8 μM ADP, although in vitro addition of heparin (0.1 u/ml, 0.5 u/ml and 2.5 u/ml) to baseline PRP of three subjects did not depress [ 14 C]5‐HT release. Our experiments suggest that intravenous administration of a therapeutic dose of heparin can cause a significant reversible impairment of platelet haemostatic properties, possibly by an indirect mechanism.
AR-Based Assistance System to Search Disaster Victims Using Teleoperated Unmanned Helicopter (2005)

In this paper, we introduce an immersive teleoperating system for an unmanned helicopter and an AR-based assistance system for searching disaster victims. In this system, an operator carries a backpack with a laptop PC and controls the helicopter remotely while watching a surrounding view of the helicopter through a head mounted display (HMD). Virtual buildings and textual annotations assist the search operation of disaster victims indicating the position to search rapidly and intensively. The position and the attitude of the helicopter is measured by a GPS and a gyroscope, and transmitted to the operator's PC via a wireless LAN. Using this system, we conducted experiments to find persons and verified the feasibility.
Coating of MoSi2 healing particles for self-healing thermal barrier coatings (2015)

To increase lifetime of the protective thermal barrier coatings (TBC) in jet engines and other gas turbines, a self-healing approach based on MoSi2 healing particle addition is considered. However, due to rapid oxygen transport in yttria-stabilized zirconia (YSZ), a common TBC material, premature oxidation is a major problem. This thesis investigates the feasibility of coating MoSi2 sacrificial particles with a protective Al2O3 shell to prevent this oxidation, while still retaining particle availability upon damage. Two different chemical methods, namely a sol-gel procedure and atomic layer deposition with residual chemical vapor deposition were successfully utilized to coat MoSi2 healing particles. The microcapsule composition and integrity has been investigated by means of scanning electron microscopy coupled with energy dispersive x-ray spectroscopy, x-ray diffraction and x-ray photoelectron spectroscopy. The results demonstrate that after calcining at 1200 °C for 1h in argon ?-Al2O3 shell can be formed and the shell remains intact. Subsequently the heat treated encapsulated particles were embedded in YSZ matrix followed by healing tests at 1100 and 1200 °C. The crack-healing tests proved that the shells produced by both methods remain intact at high temperatures, but also the coatings have a protective effect compared to uncoated MoSi2. Moreover, the embedded particles show a crack healing effect, indicating the feasibility of this self-healing concept.
Development of Method for Synthesis of Pt–Co Cathode Catalysts for PEM Fuel Cells (2007)

A procedure was developed to synthesize a platinum–cobalt alloy electrocatalyst for oxygen reduction using composite as a support. The catalysts were synthesized through: (i) chemical oxidation of carbon black, (ii) deposition on the oxidized carbon using a chelation method, (iii) chemical treatment in an acidic medium to remove excess of on the carbon surface, (iv) Pt deposition onto the support, and (v) postheat treatment to form the alloy catalyst. The synthesized catalyst showed improved activity and long-term stability in polymer electrolyte membrane (PEM) fuel cells when compared with a conventional catalyst. The electron probe microanalysis combined with scanning electron microscopy indicated that the content in the alloy catalyst remains stable without poisoning of the electrolyte membrane during long-term operation.
Layered Exact-Repair Regenerating Codes via Embedded Error Correction and Block Designs (2015)

A new class of exact-repair regenerating codes is constructed by stitching together shorter erasure correction codes, where the stitching pattern can be viewed as block designs. The proposed codes have the help-by-transfer property where the helper nodes simply transfer part of the stored data directly, without performing any computation. This embedded error correction structure makes the decoding process straightforward, and in some cases the complexity is very low. We show that this construction is able to achieve performance better than space-sharing between the minimum storage regenerating codes and the minimum repair-bandwidth regenerating codes, and it is the first class of codes to achieve this performance. In fact, it is shown that the proposed construction can achieve a nontrivial point on the optimal functional-repair tradeoff, and it is asymptotically optimal at high rate, i.e., it asymptotically approaches the minimum storage and the minimum repair-bandwidth simultaneously.
Overnight switching from oxcarbazepine to eslicarbazepine acetate: an observational study (2016)

In this short-term, single-center study, an overnight switch from twice-daily OXC to once-daily ESL in patients with drug-resistant focal epilepsies resulted in improvements in side effects, quality of life, and alertness.
Citrullination of Inhibitor of Growth 4 (ING4) by Peptidylarginine Deminase 4 (PAD4) Disrupts the Interaction between ING4 and p53 (2011)

Gene expression is regulated by a number of interrelated posttranslational modifications of histones, including citrullination. For example, peptidylarginine deminase 4 (PAD4) converts peptidyl arginine to citrulline in histone H3 and can repress gene expression. However, regulation of gene expression through citrullination of non-histone proteins is less well defined. Herein, we identify a tumor suppressor protein, inhibitor of growth 4 (ING4), as a novel non-histone substrate of PAD4. ING4 is known to bind p53 via its nuclear localization signal (NLS) region and to enhance transcriptional activity of p53. We show that PAD4 preferentially citrullinates ING4 in the same NLS region and thereby disrupts the interaction between ING4 and p53. A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression. In addition, we found that citrullination leads to increased susceptibility of ING4 to degradation, likely impacting p53-independent pathways as well. These findings elucidate an interaction between posttranslational citrullination, acetylation, and methylation and highlight an unusual mechanism whereby citrullination of a non-histone protein impacts gene regulation.