gebhart/patrepeval huggingface dataset:
Verbesserung der Kontexterkennung in Ubiquitären Informationsumgebungen (2007)

Ziel dieser Arbeit ist es, kontextverarbeitende Anwendungen einer ubiquitären Informationsumgebung, systematisch umzustrukturieren und zu erweitern, so dass eine signifikante Verbesserung in der Erkennung von Kontexten erreicht werden kann. Dazu wurde das Konzept des systematischen Kontextmanagements eingeführt, das eine neue Schicht innerhalb kontextverarbeitender Systeme bildet. Voraussetzung für effiziente Qualitätssicherungsmechanismen ist eine systematische und formale Ausgestaltung der Repräsentation, Verarbeitung und Kommunikation von Kontexten. Ein solches formales Modell einer ubiquitären Informationsumgebung wurde hier eingeführt. Es bildet die Grundlage des Qualitätsmanagements für Kontexte. Der zentrale Beitrag dieser Arbeit ist ein Qualitätsmanagementsystem für Kontexte auf der Basis von Kontextattributen. Attribute sind dabei allgemeine Eigenschaften von Kontextdaten, welche von der semantischen Bedeutung, die Kontexte für die Anwendungen einer ubiquitären Informationsumgebung haben, unabhängig sind. Das vorgestellte Modell definiert vier solche Attribute: das Kontextalter, die räumliche Herkunft des Kontextes, die Verlässlichkeit der Kontextinformation und die informationelle Abhängigkeit von Kontexten. Für jedes dieser Attribute werden konkrete Algorithmen und Verfahren eingeführt, welche die quantitative Beurteilung der Qualität einer Kontextinformation erlauben. Diese werden innerhalb der neu eingeführten Kontextmanagementschicht in einem Qualitätsfilter umgesetzt. Durch die Filterkomponente erhalten alle Artefakte die Möglichkeit, dynamisch die eingehenden Kontexte auf der Basis ihrer Qualitätsmaße zu filtern und so ihre eigene Dienstqualität zu verbessern. Im Ergebnis konnte, durch das hier vorgestellte Kontextmanagementsystem, eine Verbesserung der Erkennungsrate von Artefakten einer ubiquitären Informationsumgebung um bis zu 48% nachgewiesen werden.
Regulation of Actin Dynamics by WASP Family Proteins (2003)

Rapid reorganization of the actin cytoskeleton underlies morphological changes and motility of cells. WASP family proteins have received a great deal of attention as the signal-regulated molecular switches that initiate actin polymerization. The first member, WASP, was identified as the product of a gene of which dysfunction causes the human hereditary disease Wiskott-Aldrich syndrome. There are now five members in this protein family, namely WASP, N-WASP, WAVE/Scar1, 2, and 3. WASP and N-WASP have functional and physical associations with Cdc42, a Rho family small GTPase involved in filopodium formation. In contrast, there is evidence that links the WAVE/Scar proteins with another Rho family protein, Rac, which is a regulator of membrane ruffling. All WASP family members have a VCA domain at the C-terminus through which Arp2/3 complex is activated to nucleate actin polymerization. Analyses of model organisms have just begun to reveal unexpected functions of WASP family proteins in multicellular organisms.
Transverse entanglement migration in Hilbert space (2007)

We show that, although the amount of mutual entanglement of photons propagating in free space is fixed, the type of correlations between the photons that determine the entanglement can dramatically change during propagation. We show that this amounts to a migration of entanglement in Hilbert space, rather than real space. For the case of spontaneous parametric down-conversion, the migration of entanglement in transverse coordinates takes place from modulus to phase of the biphoton state and back again. We propose an experiment to observe this migration in Hilbert space and to determine the full entanglement.
Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line (2015)

Background. Chemotherapy, radiotherapy, and surgery are routine treatments of breast cancer. However, these methods could only improve the living survival. Nowadays the combined therapy including herbals such as crocin is to study for improving breast cancer treatment. The purpose of this study was to evaluate the effects of crocin, paclitaxel, and radiation on MCF-7 cell. Methods. To evaluate the effect of crocin, paclitaxel, and radiation on survival rate of MCF-7 cells MTT assay was done. To investigate the apoptotic effect of experimental groups PI-flow cytometry was used and expression of apoptotic proteins (caspase-7, caspase-9, PARP, and p53) was studied by western blot. Results. This study revealed that the combined therapy of 0.01µmol/mL paclitaxel and 2.5 mg/mL crocin after 48 h could cause IC50 for MCF-7 cell line. This study showed that the combined therapy of 2 Gy gamma radiation with crocin could rise apoptosis in MCF-7 cell line from 21% (related to using 2 Gy gamma radiation alone) to 46.6%. Conclusion. Crocin and paclitaxel and crocin and gamma radiation had synergistic effect on MCF-7 cell line to get more significant apoptosis.
Neurogenesis From Embryo to Adult – Lessons From Flies and Mice (2020)

The human brain is composed of billions of cells, including neurons and glia, with an undetermined number of subtypes. During the embryonic and early postnatal stages, the vast majority of these cells are generated from neural progenitors and stem cells located in all regions of the neural tube. A smaller number of neurons will continue to be generated throughout our lives, in localized neurogenic zones, mainly confined at least in rodents to the subependymal zone of the lateral ventricles and the subgranular zone of the hippocampal dentate gyrus. During neurogenesis, a combination of extrinsic cues interacting with temporal and regional intrinsic programs are thought to be critical for increasing neuronal diversity, but their underlying mechanisms need further elucidation. In this review, we discuss the recent findings in <i>Drosophila</i> and mammals on the types of cell division and cell interactions used by neural progenitors and stem cells to sustain neurogenesis, and how they are influenced by glia.
Coarse Semantic-Based Motion Removal for Robust Mapping in Dynamic Environments (2020)

SLAM in dynamic environments is still a severe challenge for most feature-based SLAM systems. Moving objects will lead to terrible errors in the calculation of frame tracking and local mapping. We propose a novel method for keypoints selection to lower the negative effect brought by moving objects during map construction. To address this challenge, we concentrate on the combination of coarse semantic information and a feature-based SLAM system. In this article, a modified CenterNet object detector is proposed as the moving object detection thread for providing coarse semantic information and 2D location. The modified CenterNet can provide a faster and more accurate prediction. For each frame in a sequence, objects in a scenario will be classified into two motion states, non-static and static, according to the category prediction from the moving object detection thread. Then important processing called semantic data association is presented for motion removal in frame tracking thread and local mapping thread. In this way, the keypoints on the non-static objects will not be chosen for calculation. Finally, on this basis, a modified real-time SLAM system is presented. Experimental results in TUM indoor dataset show that the proposed SLAM system outperforms the state-of-the-art ORB-SLAM2 in dynamic environments. Besides that, our method has a better speed-accuracy trade-off than other deep learning-based SLAM systems in dynamic environments.
Optical and scintillation properties of CsI:In crystals (2013)

The work is dedicated to study of optical and scintillation properties of CsI:In crystals. Using the Bridgeman method a concentration row of CsI:In single crystals was grown with the dopant content from 10⁻⁴ to 10⁻¹ mol. %. The segregation coefficient of In in CsI was estimated to be ~0.15. In CsI:In luminescence spectra one symmetric band is observed, peaking around 545 nm, with FWHM of 0.46 eV. Under intracenter excitation 1.9 μ s exponential decay was observed. The light yield under gamma excitation of ¹³⁷Cs isotope (662 keV), measured with a shaping time of 10 μ s, was 27 000 photons/MeV. The radio-luminescence yield of CsI:In , measured by the current mode method, approached to that of CsI:Tl . Probably, this difference is connected with the presence of a stronger afterglow in CsI:In crystals.
Microwave application of high temperature superconductors (1999)

Since the discovery of a group of ceramic materials that become superconducting at liquid nitrogen temperatures, the development of materials. components and subsystems that exploit the low dissipative losses has progressed steadily to the point where they are no longer a laboratory curiosity but have become practical devices offering significant performance benefits. This review article outlines the work performed within the Marconi Research Centre on the development of RF components and subsystems that use these high temperature superconductors. A range of high performance components has been developed, including filters, oscillators and delay lines, Some of those have been integrated into subsystems, along with circuits using conventional conductors and semiconductors, to form switched filter banks. passive filter combiner; and frequency resolving multiplexors. The enabling and supporting technologies such as cryo-packaging and cooling have matured and commercial exploitation is emerging. Developments for military applications offering enhanced performance to radar and EW systems have reached an advanced stage. Similar commercial subsystems for telecommunications have been manufactured.
Simultaneous Drill and Case Technology-Case Histories, Status and Options for Further Development (2000)

Abstract Drilling liner technology has become a standard for entering depleted reservoirs in areas of the North Sea and Southeast Asia and interest continues to increase for use of drilling liners to overcome other drilling problems. Marketing analyses have shown that further development of drilling liner technology and application has been rated with high priority. Based on experience gathered during the last five years, this paper covers possible further Drilling Liner applications, new challenges, and requirements for new systems. "Drill and Case" systems will be introduced and benefits shown by means of case histories of jobs carried out in Norway and Indonesia.
Headgroup Effects of Template Monolayers on the Adsorption Behavior and Conformation of Glucose Oxidase Adsorbed at Air/Liquid Interfaces (2011)

Stearic acid (SA) and octadecylamine (ODA) monolayers at the air/liquid interface were used as template layers to adsorb glucose oxidase (GOx) from aqueous solution. The effect of the template monolayers on the adsorption behavior of GOx was studied in terms of the variation of surface pressure, the evolution of surface morphology observed by BAM and AFM, and the conformation of adsorbed GOx. The results show that the presence of a template monolayer can enhance the adsorption rate of GOx; furthermore, ODA has a higher ability, compared to SA, to adsorb GOx, which is attributed to the electrostatic attractive interaction between ODA and GOx. For adsorption performed on a bare surface or on an SA monolayer, the surface pressure approaches an equilibrium value (ca. 8 mN/m) after 2 to 3 h of adsorption and remains nearly constant in the following adsorption process. For the adsorption on an ODA monolayer, the surface pressure will increase further 1 to 2 h after approaching the first equilibrium pressure, which is termed the second adsorption stage. The measurement of circular dichroism (CD) spectroscopy indicates that the Langmuir-Blodgett films of adsorbed GOx transferred at the first equilibrium state (π = 8 mN/m) have mainly a β-sheet conformation, which is independent of the type of template monolayers. However, the ODA/GOx LB film transferred at the second adsorption stage has mainly an α-helix conformation. It is concluded that the specific interaction between ODA and GOx not only leads to a higher adsorption rate and adsorbed amount of GOx but also induces a conformation change in adsorbed GOx from β-sheet to α-helix. The present results indicate that is possible to control the conformation of adsorbed protein by selecting the appropriate template monolayer.
A high transconductance GaAs MESFET with reduced short channel effect characteristics (1985)

A high g <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</inf> , 375 mS/mm (V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</inf> = -0.09 V), has been achieved from a 0.3 µm long gate GaAs MESFET with a very small short channel effect by employing an MBE grown channel layer. The maximum K - value obtained was 410 mS/Vmm, which is the highest ever reported for GaAs MESFETs. A unique technology, combining sidewall - assisted self - alignment technology (SWAT) and refractory metal gate n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> selective ion - implantation technology, was successfully applied to the fabrication of a GaAs MESFET with MBE grown channel layer in this work, resulting in a very low source series resistance of 0.3 Ωmm. FET characteristic dependences on gate length were also compared for FETs with different doping concentrations. The highly doped channel turned out to be effective to reduce the short channel effects and to improve the FET load drivability.
Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin (1999)

Active matrix metalloproteinases and degraded collagen are observed in disease states, such as atherosclerosis. To examine whether degraded collagen fragments have distinct effects on vascular smooth muscle cells (SMC), collagenase-digested type I collagen was added to cultured human arterial SMC. After addition of collagen fragments, adherent SMC lose their focal adhesion structures and round up. Analysis of components of the focal adhesion complex demonstrates rapid cleavage of the focal adhesion kinase (pp125(FAK)), paxillin, and talin. Cleavage is suppressed by inhibitors of the proteolytic enzyme, calpain I. In vitro translated pp125(FAK) is a substrate for both calpain I- and II-mediated processing. Mapping of the proteolytic cleavage fragments of pp125(FAK) predicts a dissociation of the focal adhesion targeting (FAT) sequence and second proline-rich domain from the tyrosine kinase domain and integrin-binding sequence. Coimmunoprecipitation studies confirm that the ability of pp125(FAK) to associate with paxillin, vinculin, and p130cas is significantly reduced in SMC treated with degraded collagen fragments. Further, there is a significant reduction in the association of intact pp125(FAK) with the cytoskeletal fraction, while pp125(FAK) cleavage fragments appear in the cytoplasm in SMC treated with degraded collagen fragments. Integrin-blocking studies indicate that integrin-mediated signals are involved in degraded collagen induction of pp125(FAK) cleavage. Thus, collagen fragments induce distinct integrin signals that lead to initiation of calpain-mediated cleavage of pp125(FAK), paxillin, and talin and dissolution of the focal adhesion complex.
Conditioning Truncated Gaussian Realizations to Static and Dynamic Data (2004)

Summary The truncated Gaussian method is based on the transformation of continuous Gaussian realizations into discrete facies realizations. Each facies is associated to an interval that depends on its volume fraction. At a given location, the value of the continuous realization identifies an interval and, therefore, a facies. Within this context, the purpose of history matching is to produce facies realizations in agreement with the static facies observations and the measured dynamic data (pressures, water cuts, and flow rates). This problem is addressed through an optimization process: we minimize an objective function that measures the mismatch between the measured dynamic data and the corresponding simulated ones. During this iterative process, many truncated Gaussian realizations are investigated until we obtain the one that best reproduces the dynamic data. To account for the static data, all of the investigated truncated Gaussian realizations are constrained to the facies observations. This intermediate step is not as obvious as it seems. It requires the conversion of the facies observations to Gaussian values that respect both the spatial structure and the intervals characterizing the facies. Up to now, the algorithms that perform this conversion were very slow and were thus only used once during the optimization process. This constraint has a significant negative impact on the minimization of the objective function. We develop a new, and fast, conversion algorithm that turns facies observations into Gaussian values respecting the spatial structure and the intervals. In addition, it is well-suited for the gradual deformation algorithm. With the new proposed methodology, the converted Gaussian values can be gradually modified at the same time as the spatial distribution of the facies. This greatly speeds up the matching process. A numerical example is shown to compare the performance of the new matching approach with that of the conventional one.
Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice (2019)

Background: Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation. The objective of the present study was to test the effect of topical versus intracerebroventricular administration of XPro1595 (a solTNF inhibitor) and etanercept (a solTNF and tmTNF inhibitor) compared to saline on output measures such as infarct volume and post-stroke inflammation in mice. Methods: Adult male C57BL/6 mice were treated topically (2.5 mg/ml/1µl/hr for 3 consecutive days) or intracerebroventricularly (1.25 mg/kg/0.5 ml, once) with saline, XPro1595, or etanercept immediately after permanent middle cerebral artery occlusion (pMCAO). Mice were allowed to survive 1 or 3 days. Infarct volume, microglial and leukocyte profiles, and inflammatory markers were evaluated. Results: We found that topical, and not intracerebroventricular, administration of XPro1595 reduced infarct volume at both 1 day and 3 days after pMCAO. Etanercept showed no effect. We observed no changes in microglial or leukocyte populations. XPro1595 increased gene expression of P2ry12 at 1 day and Trem2 at 1 and 3 days, while decreasing Cx3cr1 expression at 1 and 3 days after pMCAO, suggesting a change in microglial activation towards a phagocytic phenotype. Conclusions: Our data demonstrate that topical administration of XPro1595 for three consecutive days decreases infarct volumes after ischemic stroke, while modifying microglial activation and the inflammatory response post-stroke. This suggests that inhibitors of solTNF hold great promise for future neuroprotective treatment in ischemic stroke.
Chemistry of organic fluorine compounds II: a critical review (1996)

Survey of the Literature of Organic Fluorine Chemistry Survey of Fluorinating Agents Methods of Introducing Fluorine into Organic Molecules: Addition of Fluorine Addition of Hydrogen Fluoride Addition of Halogen Fluorides to Unsaturated Systems Addition of Fluorine and Other Elements Replacement of Hydrogen by Fluorine Replacement by Means of High-Valency Fluorides Electrophilic Fluorination of Carbon-Hydrogen Bonds Replacement of Halogens by Fluorine Replacement of Oxygen by Fluorine Replacement of Sulfur by Fluorine Replacement of Nitrogen by Fluorine Reactions of Organic Fluorine Compounds Reduction Oxidation Halogenation Nitration Nitrosation Sulfonation Acid-Catalyzed Syntheses Hydrolysis Alkylation Fluorocarbene Insertions Arylation Acylation Fluorinated Sulfur, Phosphorus, Boron, and Silicon Compounds Base-Catalyzed Condensation Reactions of Fluoromagnesium and Fluorolithium Compounds Other Organometallic Syntheses Additions: Linear Additions across Double Bonds Linear Additions to Acetylenic Compounds Cycloadditions Forming Three- and Four-Membered Rings Cycloadditions Forming Five- and Six-membered Rings Addition Reactions across Polyfluoroalkyl- and Perfluoroalkyl-Substituted CO and CN Multiple Bond Systems Eliminations Molecular Rearrangements andd Pyrolysis Fluorinated Compounds as Reagents Properties of Fluorinated Compounds Physical and Physicochemical Properties Biological Properties Analysis of Organic Fluorine Compounds Destructive Analytical Methods Modern Methods of Separation, Identification, and Structure Determination Nuclear Magnetic Resonance Spectroscopy of Organofluorine Compounds Application of Fluorinated Compounds Refrigerants, Propellants, and Foam-Blowing Agents Fire Suppression Agents Organic Fluoropolymers Fluorinated Pharmaceuticals ']8F-Labeled Radiopharmaceuticals Fluorinated Anesthetics Perfluorinated Liquids in Biology and Medicine Fluorinated Agrochemicals
Analog fault testing through abstraction (2017)

Despite analog SPICE-like simulators have reached their maturity, most of them were not originally conceived for simulating faulty circuits. With the advent of smart systems, fault testing has to deal with models encompassing both analog and digital blocks. Due to their complexity, the industry is still lacking of effective testing approaches for these analog and mixed-signal (AMS) models. The current problem is the computational time required for implementing an analog fault simulation campaign. To this end, the work presented in this paper is an automatic procedure which: 1) injects faults in an analog circuit, 2) abstracts both faulty and fault-free models from the circuit to the functional level, 3) builds an efficient fault simulation framework. The processes of fault injection, faulty model abstraction and framework generation are reported in details, as well as how simulation is carried out. This abstraction process, which preserves the faulty behaviors, allows to reach a speed-up of some orders of magnitude and thus, making feasible an extensive analog faults campaign.
Neutrophil migration-inhibition activity produced by a unique T lymphoblast cell line. (1979)

Fifteen lymphoblast cell lines, including B cell, T cell, Null cell, and myeloblast cells, were examined for the production of human neutrophil migration-inhibition activity. Only one T lymphoblast cell line established from a patient with hairy cell leukemia produced a neutrophil migration-inhibition factor spontaneously and after stimulation with Con A and PHA.
Far-infrared multilayer mirrors (2003)

We present a concept for highly reflecting broadband mirrors in the far-infrared. We report on the fabrication of dielectric multilayer mirrors consisting of 1–6 layers of silicon wafers with vacuum gaps in between. By comparison to gold mirrors, we can demonstrate the high reflectivity (&gt;99%) over the frequency range between 40 and 130 cm−1. The measurements are in very good agreement with theoretical predictions.