gebhart/patrepeval huggingface dataset:
4D Cities: Analyzing, Visualizing, and Interacting with Historical Urban Photo Collections (2012)

Vast collections of historical photographs are being digitally archived and placed online, providing an objective record of the last two centuries that remains largely untapped. In this work, we propose that time-varying 3D models can pull together and index large collections of images while also serving as a tool of historical discovery, revealing new information about the locations, dates, and contents of historical images. In particular, we use computer vision techniques to tie together large sets of historical photographs of a given city into a consistent 4D model of the city: a 3D model with time as an additional dimension.
Capillary Electrophoresis Measurements of Electrophoretic Mobility for Colloidal Particles of Biological Interest (1998)

The electrophoretic mobilities of three bacterial strains were investigated by capillary electrophoresis (CE) and were compared with results obtained by microelectrophoresis (ME). The CE measurements yielded bimodal electropherograms for two of the strains, thus illustrating for the first time that surface charge variations within a monoclonal population can be probed by CE. Intrapopulation variations were not detected by ME. The mobilities of three chemically distinct types of latex microspheres were also measured. Differences between the mean mobilities obtained by CE and ME were not statistically significant (P </= 0.50); the standard deviations of the CE measurements were typically 2 to 10 times smaller than those obtained by comparable ME measurements. The reproducibility of CE permitted batch-to-batch mobility variations to be probed for the bacteria (one of the strains exhibited such variations), and aggregation was evident in one of the latex suspensions. These effects were not measurable with ME.
Infrastructure-as-Code for Data-Intensive Architectures: A Model-Driven Development Approach (2018)

As part of the DevOps tactics, Infrastructure-as-Code (IaC) provides the ability to create, configure, and manage complex infrastructures by means of executable code. Writing IaC, however, is not an easy task, since it requires blending different infrastructure programming languages and abstractions, each specialized on a particular aspect of infrastructure creation, configuration, and management. Moreover, the more the architectures become large and complex (e.g. Data-Intensive or Microservice-based architectures), the more dire the need of IaC becomes. The goal of this paper is to exploit Model-Driven Engineering (MDE) to create language-agnostic models that are then automatically transformed into IaC. We focus on the domain of Data-Intensive Applications as these typically exploit complex infrastructures which demand sophisticated and fine-grained configuration and re-configuration - we show that, through our approach, called DICER, it is possible to create complex IaC with significant amounts of time savings, both in IaC design as well as deployment and re-deployment times.
Electrical Switching in Semiconductor-Metal Self-Assembled VO2 Disordered Metamaterial Coatings (2016)

As a strongly correlated metal oxide, VO<sub>2</sub> inspires several highly technological applications. The challenging reliable wafer-scale synthesis of high quality polycrystalline VO<sub>2</sub> coatings is demonstrated on 4" Si taking advantage of the oxidative sintering of chemically vapor deposited VO<sub>2</sub> films. This approach results in films with a semiconductor-metal transition (SMT) quality approaching that of the epitaxial counterpart. SMT occurs with an abrupt electrical resistivity change exceeding three orders of magnitude with a narrow hysteresis width. Spatially resolved infrared and Raman analyses evidence the self-assembly of VO<sub>2</sub> disordered metamaterial, compresing monoclinic (M1 and M2) and rutile (R) domains, at the transition temperature region. The M2 mediation of the M1-R transition is spatially confined and related to the localized strain-stabilization of the M2 phase. The presence of the M2 phase is supposed to play a role as a minor semiconducting phase far above the SMT temperature. In terms of application, we show that the VO<sub>2</sub> disordered self-assembly of M and R phases is highly stable and can be thermally triggered with high precision using short heating or cooling pulses with adjusted strengths. Such a control enables an accurate and tunable thermal control of the electrical switching.
Quantitative Determination of Sialic Acid in the Monosialoganglioside, GM1, by the Thiobarbituric Acid Method (1997)

Several methods for the quantitative analysis of sialic acids in glycoconjugates require that the sialic acid glycosidic bond be cleaved prior to assay. The conventional (L. Svennerholm, (1958) Acta Chem. Scand. 12, 547-554) procedure for the hydrolysis of complex carbohydrates such as gangliosides employs 0.1 n H+ at 80 degrees C for 60 min. Under these conditions, we find that the monosialoganglioside (GM1) yields less than 50% of the total sialic acid. However, 90% recovery of sialic acid was achieved by supplementing the hydrolysis mixture with 0.2% sodium dodecylsulfate (SDS) and increasing the temperature to 85 degrees C. During hydrolysis under these conditions, N-acetylneuraminic acid (NAN) is degraded at about 7% per hour. If the analytical values for GM1 are corrected for degradation, the recovery of NAN is essentially quantitative.
44 viviendas dotacionales para gente mayor en Quatre Camins (2019)

Este proyecto parte de una volumetria compacta en su fachada a la via publica para descomponerse y escalonarse en su fachada interior, con el objetivo de mejorar su relacion con los patios de las viviendas vecinas. 
Este proyecto plantea la construccion de un edificio urbano alineado a las calles y abierto hacia la buena orientacion y las vistas, en un lugar en el que la mayor parte de las viviendas se orientan a sur o sureste. Con un nucleo principal de escalera y ascensores y otra escalera secundaria de evacuacion, se da acceso a cuarenta y cuatro viviendas, dos de ellas adaptadas. Todas las viviendas, con una superficie util computable de unos cuarenta y un metros cuadrados aproximadamente, tienen un espacio exterior confortablemente protegido, sobre todo las del nivel inferior, cuya situacion les permite disponer de un espacio de mayor dimension. 
Tambien se ha procurado que la adaptacion a la topografia del solar absorbiera espacios comunitarios, como aulas polivalentes interiores, espacios exteriores, recepcion, conserjeria, cuartos de limpieza, lavanderia, tendederos... Toda una serie de espacios de relacion sin desniveles y bien orientados, en los que la gente mayor pueda llevar a cabo todo tipo de actividades de ocio y servicios. Es por ello que tanto en la planta de acceso como en la planta primera, y en la mas alta del edificio, el espacio interior crea continuidades con el exterior, generando ambitos de estancia al aire libre que aprovechan el escalonamiento del terreno. La volumetria final del edificio se presenta compacta de cara a la calle, mientras que se descompone y escalona en el lado interior del solar, acogiendo la orientacion sur y haciendo mas domestico el contacto con los patios de las viviendas vecinas. 
En relacion a la fachada, se plantea un aislamiento continuo exterior de 15cm de espesor tipo StoTherm con un refuerzo de malla de obra de vidrio sobre previa capa de enlucido. La disposicion de aberturas protegidas y controladas por celosias y persianas permite prever su contribucion al buen comportamiento energetico del edificio. Este proyecto viene precedido de un informe elaborado por Energiehaus, en el que se incluye un conjunto de medidas para garantizar que el proyecto cumpla con las exigencias de un edificio Passivhaus. La ventilacion de todas las zonas comunes de planta baja se realiza por medio de unidades de tratamiento de aire de doble flujo, con recuperacion de energia. En las viviendas se ha realizado la climatizacion mediante una unidad exterior de aerotermia. Este sistema asegura una produccion de agua caliente para ACS, que mediante una valvula de tres vias se deriva para la climatizacion de la vivienda, incorporando tan solo dos radiadores, uno en salon y otro en el dormitorio.
Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice (2021)

The deposition of mutant huntingtin (mHTT) protein aggregates in neurons of patients is a pathological hallmark of Huntington's disease (HD). Previous investigations in cell-free and cell-based disease models showed mHTT exon-1 (mHTTex1) fragments with pathogenic polyglutamine (polyQ) tracts (>40 glutamines) to self-assemble into highly stable, β-sheet-rich protein aggregates with a fibrillar morphology. HD knock-in mouse models have not been extensively studied with regard to mHTT aggregation. They endogenously produce full-length mHTT with a pathogenic polyQ tract as well as mHTTex1 fragments. Here, we demonstrate that seeding-competent, fibrillar mHTT aggregates can be readily detected in brains of zQ175 knock-in HD mice. To do this, we applied a highly sensitive FRET-based protein amplification assay that is capable of detecting seeding-competent mHTT aggregate species down to the femtomolar range. Furthermore, we show that fibrillar structures with an average length of ∼200 nm can be enriched with aggregate-specific mouse and human antibodies from zQ175 mouse brain extracts through immunoprecipitations, confirming that such structures are formed <i>in vivo</i>. Together these studies indicate that small, fibrillar, seeding-competent mHTT structures are prominent aggregate species in brains of zQ175 mice.
Estimation of vehicle roll and road bank angle (2004)

This work presents a new method for identifying road bank and vehicle roll separately using a disturbance observer and a vehicle dynamic model. The authors have previously shown that vehicle states and parameters of a vehicle model can be precisely estimated using measurements from Global Positioning System (GPS) and Inertial Navigation System (INS) sensors. Based on these results, a dynamic model, which includes vehicle roll as a state and road bank as a disturbance, is first introduced. A disturbance observer is then implemented from the vehicle model using estimated vehicle states. Experimental results verify that the estimation scheme is giving appropriate estimates of the vehicle roll and road bank angles separately.
Chemical Modification of Silk Sericin in Lithium Chloride/Dimethyl Sulfoxide Solvent with 4-Cyanophenyl Isocyanate (2004)

This paper reports chemical modification of silk sericin in LiCl/dimethyl sulfoxide (DMSO) solvent with 4-cyanophenyl isocyanate. Sericin is a highly hydrophilic protein secreted by Bombyx mori, serving as a protein glue in a cocoon. LiCl/DMSO was found to be a good solvent of sericin and useful for homogeneous modification of its abundant hydroxyl groups under nonaqueous condition. Fourier transform infrared (FTIR) analysis of the modified sericins revealed that 4-cyanophenyl groups were incorporated into sericin molecules mainly through urethane linkages. Several characteristics of the modified sericins such as solubility characteristic, hygroscopic property, and thermal stability were investigated. Secondary structure analysis using FTIR spectra suggested that formation of strong intermolecular hydrogen bonds was inhibited by the modification that is probably attributable to the incorporation of bulky 4-cyanophenyl groups. These results demonstrate that chemical modification of sericin using LiCl/DMSO solvent markedly alters its characteristics.
Parasitic capacitance influence of potential-sensing electrodes on four-electrode liquid impedance measurements (2009)

Four-electrode techniques are used to minimize the effects of electrode polarization on measurements of the frequency-dependent impedance of conductive solutions. Basic circuit analysis confirms that an ideal Schwan-type four-electrode measurement can theoretically determine the polarization-free impedance of a sample. However, circuit analysis including parasitic effects indicates that the input impedance of the potential-sensing electrodes will be a significant influence on the measurement. This is verified in experiments on conductive solutions employing measurements of the gain and phase between potential-sensing electrodes in a four-electrode arrangement. The electrode impedance is varied by adding capacitors in parallel with the probes. The combined theory and experimental data indicate that parasitic capacitance of the potential-sensing electrodes is non-negligible and will alter the measured capacitance at all frequencies and even distort conductivity measurements at high-frequencies. This result has significant implications for the feasibility of broadband measurements of liquids based on four-electrode impedance methods.
Neuroendocrine Aspects of the Molecular Chaperones ADNF and ADNP (2005)

Vasoactive intestinal peptide (VIP), which was originally discovered in the intestine as a 28–amino acid peptide and shown to induce vasodilation, was later found to be a major brain peptide with neuroprotective activities in vivo [1–5]. To exert neuroprotective activity in the brain, VIP requires glial cells that secrete protective proteins such as activity-dependent neurotrophic factor (ADNF [6]). ADNF, isolated by sequential chromatographic methods, was named activity-dependent neurotrophic factor because it protects neurons from death associated with the blockade of electrical activity.
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons (2011)

Neuronal migration is essential for the development of the mammalian brain. Here, we document severe defects in neuronal migration and reduced numbers of neurons in lamin B1-deficient mice. Lamin B1 deficiency resulted in striking abnormalities in the nuclear shape of cortical neurons; many neurons contained a solitary nuclear bleb and exhibited an asymmetric distribution of lamin B2. In contrast, lamin B2 deficiency led to increased numbers of neurons with elongated nuclei. We used conditional alleles for Lmnb1 and Lmnb2 to create forebrain-specific knockout mice. The forebrain-specific Lmnb1- and Lmnb2-knockout models had a small forebrain with disorganized layering of neurons and nuclear shape abnormalities, similar to abnormalities identified in the conventional knockout mice. A more severe phenotype, complete atrophy of the cortex, was observed in forebrain-specific Lmnb1/Lmnb2 double-knockout mice. This study demonstrates that both lamin B1 and lamin B2 are essential for brain development, with lamin B1 being required for the integrity of the nuclear lamina, and lamin B2 being important for resistance to nuclear elongation in neurons.
Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish <scp>GA</scp>(2)<scp>LEN</scp> (2017)

We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype-specific biomarker in asthma.
Frontispiece: Towards More Photostable, Brighter, and Less Phototoxic Chromophores: Synthesis and Properties of Porphyrins Functionalized with Cyclooctatetraene (2020)

Free bases and zinc porphyrins were substituted with cyclooctatetraene, a triplet quencher, in three different fashions in order to enhance their photostability. Large decrease of the lifetime of porphyrin triplet state was observed. Photostability has been significantly improved in oxygen-free solutions. In non-degassed solutions, the improvement has been achieved for zinc porphyrins, but not for the free bases. For more details see the Full Paper by J. Waluk, J. Ostapko et al. on page 16666.
Vonoprazan and Helicobacter pylori Treatment: A Lesson From Japan or a Limited Geographic Phenomenon? (2019)

Within a short time after the discovery of <i>Helicobacter pylori</i>, its critical role in many gastroduodenal disorders became evident. Many <i>in vitro</i> and <i>in vivo</i> data have proven that infection should be treated in order to avoid lasting colonization which may lead to problematic gastroduodenal diseases. Probiotics, preventive and therapeutic vaccines and antibiotic therapy are the main options proposed to cure these disorders. 25 years ago, triple therapy including a traditional proton pump inhibitor (PPI) and two antibiotics (amoxicillin and clarithromycin or metronidazole) was defined as the best therapy formulation for the <i>H. pylori</i> infection. With the strongly decreased effectiveness of this scheme, many empirical therapeutic regimens have been developed. However, the prevalence of resistance is increasing worldwide and reveals important geographic differences and even the most recent and effective regimens show some critical points. Therefore, efficacy of vonoprazan-based therapy in regions with low rate of clarithromycin resistance may be limited. In this review, we attempt to open a new window to overcome the problem of antibiotic resistance to <i>H. pylori</i>. In fact, we focused our attention on the possibility that conventional PPI may be replaced by vonoprazan, thus giving rise to the beginning of a new era characterized by an improved therapeutic option for <i>H. pylori</i> infection. Therefore, we hypothesize that switching to vonoprazan as a novel acid blocker for <i>H. pylori</i> treatment might allow an unexpected reassessment of the triple therapy, at least in regions with low rate of clarithromycin resistance. Nevertheless, this optimistic view of the problem could be disproved by the possible failure of vonoprazan based therapeutic regimens outside of Japan in geographic areas characterized by different rates of antibiotic resistances.
Peripheral arterial calcification: Prevalence, mechanism, detection, and clinical implications (2014)

Vascular calcification (VC), particularly medial (Mönckeberg's medial sclerosis) arterial calcification, is common in patients with diabetes mellitus and chronic kidney disease and is associated with increased cardiovascular morbidity and mortality. Although, the underlying pathophysiological mechanisms and genetic pathways of VC are not fully known, hypocalcemia, hyperphosphatemia, and the suppression of parathyroid hormone activity are central to the development of vessel mineralization and, consequently, bone demineralization. In addition to preventive measures, such as the modification of atherosclerotic cardiovascular risk factors, current treatment strategies include the use of calcium-free phosphate binders, vitamin D analogs, and calcium mimetics that have shown promising results, albeit in small patient cohorts. The impact of intimal and medial VC on the safety and effectiveness of endovascular devices to treat symptomatic peripheral arterial disease (PAD) remains poorly defined. The absence of a generally accepted, validated vascular calcium grading scale hampers clinical progress in assessing the safety and utility of various endovascular devices (e.g., atherectomy) in treating calcified vessels. Accordingly, we propose the peripheral arterial calcium scoring system (PACSS) and a method for its clinical validation. A better understanding of the pathogenesis of vascular calcification and the development of optimal medical and endovascular treatment strategies are crucial as the population ages and presents with more chronic comorbidities.
Human umbilical cord mesenchymal stem cell‐derived extracellular vesicles: A novel therapeutic paradigm (2019)

Mesenchymal stem cells (MSCs) have been revealed to hold great potential for the development of new treatment approaches for various diseases. However, the clinical use of these cells is limited due to their tumorigenic effects. The therapeutic benefits of MSCs are largely dependent on paracrine factors including extracellular vesicles (EVs). EVs are nano-sized bilayer membrane structures containing lipids, microRNAs and proteins which play key roles in cell-to-cell communications. Because of their lower immunogenicity, tumorigenicity, and easier management, EVs have emerged as a new promising alternative to whole-cell therapy. Therefore, this paper reviews current preclinical studies on the use of EVs derived from human umbilical cord MSCs (hucMSCs) as a therapeutic approach in treatment of several diseases including neurological, cardiovascular, liver, kidney, and bone diseases as well as the cutaneous wound, inflammatory bowel disease, cancers, infertility, and other disorders.
Film [sic] (2013)

Research Article| December 01 2013 Film [sic] B. Ruby Rich B. Ruby Rich Search for other works by this author on: This Site PubMed Google Scholar Film Quarterly (2013) 67 (2): 5–7. https://doi.org/10.1525/fq.2014.67.2.5 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation B. Ruby Rich; Film [sic]. Film Quarterly 1 December 2013; 67 (2): 5–7. doi: https://doi.org/10.1525/fq.2014.67.2.5 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentFilm Quarterly Search This content is only available via PDF. © 2014 by the Regents of the University of California2014 Article PDF first page preview Close Modal You do not currently have access to this content.
Formulation and evaluation of rapidly disintegrating film of Levocetrizine Hydrochloride (2010)

In the present study fast dissolving film of levocetrizine hydrochloride was prepared using sodium alginate as film forming polymer. To decrease the disintegration time of formulations sodium starch glycolate was used as disintegrating agent. A full 32 factorial design was applied using concentration of polymer and disintegrant as independent variable and disintegration time and % cumulative drug release as dependent variable. Response surface curves were plotted. Batch F6 was found to be the optimized batch as its disintegration was completed within the minimum time as compared to all other batches. The formulation (F6) was also showing sufficient drug release after 6 min. All the nine formulation was showing approximately 70-85% drug release after 6 min.
The SecureRing protocols for securing group communication (2002)

The SecureRing group communication protocols provide reliable ordered message delivery and group membership services despite Byzantine faults such as might be caused by modifications to the programs of a group member following illicit access to, or capture of, a group member. The protocols multicast messages to groups of processors within an asynchronous distributed system and deliver messages in a consistent total order to all members of the group. They ensure that correct members agree on changes to the membership, that correct processors are eventually included in the membership, and that processors that exhibit detectable Byzantine faults are eventually excluded from the membership. To provide these message delivery and group membership services, the protocols make use of an unreliable Byzantine fault detector.
Wireless data acquisition and logging in shallow water environments (2003)

Collecting environmental data in shallow water areas can be a challenging task. Difficulties include covering large territories and the presence of inaccessible areas due to a variety of reasons such as a soft bottom or contamination. There is also a high chance of disturbing the test area while placing the sensors. This paper describes the design and development of a remotely-operated system that transmits data wirelessly to a computer on shore in real-time. The paper also presents and discusses test results and addresses future plans.