gebhart/patrepeval huggingface dataset:
New human renin inhibitors containing an unnatural amino acid, norstatine (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew human renin inhibitors containing an unnatural amino acid, norstatineKinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, and Yoshiaki KisoCite this: J. Med. Chem. 1988, 31, 4, 701–704Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/jm00399a001https://doi.org/10.1021/jm00399a001research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
2´-Deoxy Purine, 2´-O-Methyl Pyrimidine (dRmY) Aptamers as Candidate Therapeutics (2006)

Aptamers are short oligonucleotides that fold into well-defined three-dimensional architectures thereby enabling specific binding to molecular targets such as proteins. To be successful as a novel therapeutic modality, it is important for aptamers to not only bind their targets with high specificity and affinity, but also to exhibit favorable properties with respect to in vivo stability, cost-effective synthesis, and tolerability (i.e., safety). We describe methods for generating aptamers comprising 2 - deoxy purines and 2 -O-methyl pyrimidines (dRmY) that broadly satisfy many of these additional constraints. Conditions under which dRmY transcripts can be efficiently synthesized using mutant T7 RNA polymerases have been identified and used to generate large libraries from which dRmY aptamers to multiple target proteins, including interleukin (IL)-23 and thrombin, have been successfully discovered using the SELEX process. dRmY aptamers are shown to be highly nuclease-resistant, long-lived in vivo, efficiently synthesized, and capable of binding protein targets in a manner that inhibits their biologic activity with K(D) values in the low nM range. We believe that dRmY aptamers have considerable potential as a new class of therapeutic aptamers.
A PI-based control strategy for mitigation of torque harmonics in switched reluctance motor drives (2008)

An issue that often arises in switched reluctance machine (SRM) drives is excessive vibration/noise created by harmonics of electromagnetic torque (torque ripple). In this research, analytical techniques are used to map vibration harmonics to stator current magnitudes and phase angles. The map is used to formulate a proportional plus integral (PI) control that adjusts current amplitude and phase in response to measured vibration. Simulation and hardware results are presented that demonstrate the effectiveness of the proposed methods.
High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer (2007)

In a prospective study, we have examined the tumor-specific immune response in a group of 59 patients with human papillomavirus (HPV) 16-positive (HPV16(+))-induced or HPV18(+)-induced cervical cancer. Local antitumor immunity was analyzed by the enumeration of tumor-infiltrating dendritic cells and CD4+, CD8+, and regulatory T cells as well as by calculation of the ratio of CD8+/CD4+ T cells and CD8+/regulatory T cells. Systemic tumor-specific immunity was assessed by determination of the HPV E6- and/or E7-specific T-cell response in the blood of these patients. Finally, these variables were evaluated with respect to known histopathologic prognostic variables, including the absence (LN-) or presence (LN+) of lymph node metastases. Stratification according to the lymph node status of patients revealed a significantly stronger CD8+ T-cell tumor infiltration, a higher CD8+/CD4+ T-cell ratio, and higher CD8+/regulatory T-cell ratio in the group of patients in which the tumor failed to metastasize to the tumor-draining lymph node. Subdivision according to the presence (IR+) or absence (IR-) of circulating HPV-specific T cells disclosed that the highest number of tumor-infiltrating CD8+ T cells was found in the group of LN- patients displaying a concomitant systemic tumor-specific immune response (LN-IR+). CD8+ T-cell infiltration in LN-IR- patients was comparable with that of LN+ patients. In cervical cancer, the absence of lymph node metastases is strongly associated with a better prognosis. Our data indicate that, especially in a subgroup of LN- patients, a strong and effective interaction between immune system and tumor exists. This subgroup of cervical cancer patients may have the best prognosis.
Higher brightness laser diodes with smaller slow axis divergence (2013)

The slow axis (SA) divergence of 20% fill-factor, 980nm, laser diodes (LDs) have been investigated under short pulsed (SP) and continuous (CW) operation. By analyzing the data collected under these two modes of operation, one finds that the SA divergence can be separated into two components: an intrinsic divergence and a thermally induced divergence. At low injected current and power, the intrinsic SA divergence is dominant while at high power their magnitudes are approximately equal. The thermal gradient across the broad stripe is negligible under SP operation and, the SA divergence increased at a much slower rate as a function of injected current, thereby increasing the brightness of the LD by 2X. SRL has redesigned microchannel coolers that remove the thermal gradient under CW operation thereby eliminating the thermally induced SA divergence resulting in LDs that are 2X brighter at 300W/bar.
Poster (2011)

We propose a new and efficient scheme for broadcast encryption. A broadcast encryption system allows a broadcaster to send an encrypted message to a dynamically chosen subset RS, |RS|=n of a given set of users, such that only users in this subset can decrypt the message. An important component of broadcast encryption schemes is revocation of users by the broadcaster, thereby updating the subset RS. Revocation may be either temporary, for a specific ciphertext, or permanent. We present the first public key broadcast encryption scheme that support permanent revocation of users. Our scheme is fully collusion resistant. In other words, even if all the users in the network collude with a revoked user, the revoked user cannot encrypt messages without receiving new keys from the broadcaster. The procedure is based on Cipher-text Policy Attribute-Based Encryption (CP-ABE).
A 4-Plate Compact Capacitive Coupler Design and LCL-Compensated Topology for Capacitive Power Transfer in Electric Vehicle Charging Applications (2016)

This paper proposes a four-plate compact capacitive coupler and its circuit model for large air-gap distance capacitive power transfer (CPT). The four plates are arranged vertically, instead of horizontally, to save space in the electric vehicle charging application. The two plates that are on the same side are placed close to each other to maintain a large coupling capacitance, and they are of different sizes to maintain the coupling between the primary and secondary sides. The circuit model of the coupler is presented, considering all six coupling capacitors. The LCL compensation topology is used to resonate with the coupler and provide high voltage on the plates to transfer high power. The circuit model of the coupler is simplified to design the parameters of the compensation circuit. Finite-element analysis is employed to simulate the coupling capacitance and design the dimensions of the coupler. The circuit performance is simulated in LTspice to design the specific parameter values. A prototype of the CPT system was designed and constructed with the proposed vertical plate structure. The prototype achieved an efficiency of 85.87% at 1.88-kW output power with a 150-mm air-gap distance.
Investigation of calculation methods of effective duration on autocorrelation-based Chinese speech recognition (2013)

The factors extracted from running autocorrelation function have phonetic and syllabic meanings, and they can be used for Chinese speech recognition. One of the factors is the effective duration of ACF envelope τe, which reveals the temporal repetitive continuity of the speech signals. The values of τe vary when different calculation methods are adopted. By adopting different calculation methods to several sets of Chinese vowels and characters, which are recorded from a group of speakers, a preferred calculation method is decided by the uniqueness of τe, that is the τe calculated by such method can mostly distinguish different vowels, characters, or even speakers.
Expression of the human neuropeptide tyrosine Y1 receptor. (1993)

Neuropeptide tyrosine (NPY) is the predominant peptide in the innervation of many human tissues and is considered to play a role in the regulation of blood flow, gastrointestinal secretion and motility, and renal function. Three NPY receptors have been identified (Y1, Y2, and Y3) and the cDNAs encoding the human Y1 and bovine Y3 receptors have recently been cloned. We have demonstrated the expression of the Y1 receptor subtype in several fetal and adult human tissues, including the colon, kidney, adrenal gland, heart, and placenta. A single transcript was identified (approximately 2.2 kb) and localized in tissue sections by in situ hybridization. In the colon the receptor is expressed in the mucosa and basal glands, as well as the myenteric and submucous plexuses. Y1 receptor mRNA was detected in renal collecting ducts, loop of Henle, and juxtaglomerular apparatus and in the syncytiotrophoblast layer of placental villi. Fetal aorta and adult intramyocardial, colonic, and renal blood vessels also exhibited receptor expression, localized to the intima as well as the media. The distribution of Y1 receptor expression correlates with that of NPY-immunoreactive nerves and the apparent actions of NPY in the intestine, kidney, and heart. Although the placenta is devoid of nerves, an NPY-like transcript was detected in the villous trophoblast layer. The results indicate a tissue-specific regulation of NPY Y1 receptor expression.
Serologic Diagnosis of Lyme Disease using Recombinant Outer Surface Proteins A and Band Flagellin (1992)

Recombinant (r) outer surface proteins (Osp) A and B, flagellin, and an immunogenic region of flagellin (41-G) from Borrelia burgdorferi were evaluated using immunoblot and ELISA for usefulness as substrates in diagnostic testing for Lyme disease. Antibodies to rOspA, rOspB, and r-flagellin were detected by immunoblot and ELISA using the recombinant proteins. Patients with late disease responded to rOspA, rOspB, and r-flagellin, or only to r-flagellin, whereas patients with early disease showed no response or responded only to r-flagellin. Patients who developed antibodies to r-flagellin also responded to 41-G. The data suggest that recombinant B. burgdorferi antigens can serve as substrates for immunoblot and ELISA, which may be helpful in diagnosing Lyme disease.
Controlled deposition of picoliter amounts of fluid using an ultrasonically driven micropipette (2004)

A fluid microplotter that uses ultrasonics to deposit small fluid features has been constructed. It consists of a dispenser, composed of a micropipette fastened to a piece of lead zirconate titanate piezoelectric, attached to a precision positioning system. When an electrical signal of the appropriate frequency and voltage is applied, solution in the tip of the micropipette wicks to the surface in a controlled fashion. The gentle pumping of fluid to the surface occurs when the micropipette is driven at frequencies in the range of 400–700 kHz. Spots with diameters smaller than several microns can be deposited in this manner. Continuous lines can also be produced. Several examples of deposited patterns and structures are described. This means of deposition represents a higher-resolution alternative to standard fluid deposition techniques in the fabrication of biological microarrays or polymer-based circuits.
Molecular Cloning and Expression of a Xylanase Gene of Alkalophilic Aeromonas sp. no. 212 in Escherichia coli (1985)

A gene coding for a xylanase activity of alkalophilic Aeromonas sp. no. 212 (ATCC 31085) was cloned in Escherichia coli HB101 with pBR322. Plasmid pAX1 was isolated from transformants producing xylanase, and the xylanase gene was located in a 6.0 kb Hind III fragment. The pAX1-encoded xylanase activity in E. coli HB101 was about 80 times higher than that of xylanase L in alkalophilic Aeromonas sp. no. 212. About 40% of the enzyme activity was observed in the periplasmic space of E. coli HB101. The pAX1-encoded xylanase had the same enzymic properties as those of xylanase L produced by alkalophilic Aeromonas sp. no. 212, but its molecular weight was lower (135 000 vs 145 000, as estimated by SDS polyacrylamide gel electrophoresis).
Impact of novel lipidized analogs of neuropeptides on food intake decrease and metabolic changes in rodents (2014)

O is a frequent metabolic disorder but an effective therapy is still scarce. Anorexigenic neuropeptides seem to be potential specific tools for obesity treatment but their peptide character complicates their delivery to the brain, necessary for their central effect, and makes them subjects of fast degradation. In order to overcome the unfavorable facts mentioned, lipidization of anorexigenic neuropeptide prolactin-releasing peptide (PrRP) whose strong anorexigenic effect was demonstrated with the fact that both PrRP and its receptor knock-outs resulted in obese phenotypes, was applied. Analogs of PrRP with attached fatty acids showed unabated biological activities compared to the native PrRP regarding binding affinity and signaling in cells expressing PrRP receptor. Most interestingly, these analogs revealed a strong and long-lasting anorexigenic effects after their peripheral administrations to fasted mice and rats and neuronal activation in brain areas involved in food intake regulation. Moreover, repeated subcutaneous administration of palmitoylated PrRP lowered food intake and body weight and improved metabolic parameters in diet-induced obese mice. For the anorexigenic effect of native PrRP, central administration was necessary. Lipidization of PrRP enabled its peripheral administration for its anorexigenic effect in the brain, most probably by enhancing its stability in the blood and mediating the peptide to cross the blood brain barrier.
Role of citrate in the formation of enamel-like calcium phosphate oriented nanorod arrays (2019)

The effect of citrate on the formation of oriented fluoride doped hydroxyapatite nanorods grown on an amorphous calcium phosphate substrate was investigated.
Enhancing system dependability with dynamically reconfigurable FPGAs (2002)

Configuring computing modules for fault-tolerant or parallel computing requires the presence of certain logical functions. Unavoidable tradeoffs between hardware and software implementations of these functions have created unfavorable attributes for designs. Branching and jumps in software allow only the immediately needed function to take up processing resources, but software cannot match the speed of performing the function in dedicated hardware. Hardware, however, is rigid, and permanently embodying functions in it adds to the overhead (size, weight and power) of the system. Simplifying the hardware to reduce this overhead only restricts how the modules can be configured during operation. Our architecture uses a dynamically reconfigurable field-programmable gate array (FPGA) to bring together the benefits of hardware and software while mitigating the costs of both. The resultant design supports fault tolerance and multiprocessing among computing modules flexibly and judiciously while accelerating the application throughput.
Kinetic Analysis of the Immortal Ring-Opening Polymerization of Cyclic Esters: A Case Study with Tin(II) Catalysts (2014)

A kinetic analysis of the metal-catalyzed immortal ring-opening polymerization (ROP) of cyclic esters is presented, based on a first-principles approach without making assumptions regarding the active species. The kinetics of all immortal ROP reactions performed with a metal catalyst and an exogenous chain transfer agent are characterized by the initiation, propagation and exchange rate constants (ki, kp, and ke, respectively). Curve fitting to this kinetic scheme in the initial stage of the polymerization allows the extraction of ki and kp from a single experiment. This has been illustrated for the ROP of l-lactide using tin(II) complexes of the type {LOi}Sn(X) ({LOi} = aminophenolate ancillary ligand, X = N(SiMe3)2 or methyl (S,S)-lactate), Sn(OiPr)2 or Sn(N(SiMe3)2)2 as precatalysts paired with excess iPrOH as a coactivator. Nonlinear regressions (R2 > 0.999) illustrate the three possible scenarios, ki < kp, ki = kp, and ki > kp. The kinetic model can be extended to any metal (pre)catalyst for the immortal ROP of any cyclic ester, as exemplified using trimethylene carbonate as a monomer or employing a germylene precatalyst. A kinetic treatment for the late phase of immortal ROP reactions is introduced, which also gives direct access to kp. In agreement with the ROP kinetic data for {LOi}Sn(N(SiMe3)2), Sn(OiPr)2, Sn(N(SiMe3)2)2, and the new Sn(OiPr)(N(SiMe3)2 recorded in the presence of various quantities of iPrOH, synthetic and 119Sn{1H} NMR data provide evidence for reversible production of tin(II) bis(alkoxide) when a small excess (1–3 equiv) of alcohol is used with tin(II) precatalysts. It is also shown that, regardless of the identity of the precatalyst, Sn(OiPr)2 and Sn(O-polymeryl)2 are, respectively, the actual initiating and propagating species when immortal ROP reactions are performed in the presence of a larger excess of alcohol (7 equiv or more vs Sn).
Classification with a combined information test (2002)

We introduce a discrete model for classifying a target that combines the information in training and test data to infer about the true symbol probabilities. Two tests are derived given that the symbols are distributed as a multinomial. The robustness of these tests lies in their ability to effectively use all of the information in the training and test data before making a classification decision. This is demonstrated by comparing their performance to a standard hypothesis test for a classification problem involving transmission of quantized data to a fusion center.
Local charge neutgrality condition, Fermi level, and carrier compensation of CdTe polycrystalline thin film in CdS/CdTe solar cells (2010)

In this paper we discuss the classification of localized intrinsic/impurity defect states in the band gap of semiconductors according to the charging and transition energy levels of the state being single or multiple, and according to the atomic configuration and formation of energy of the state being single or multiple. For semiconductors that have multi-level intrinsic/impurity defect states (such as Cd vacancies V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Cd</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(o/-)</sup> and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Cd</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(-/2-)</sup> in CdTe thin film), the general formulation of charge neutrality condition is given to determine the Fermi level and majority carrier density. For semiconductors that have multi-configuration intrinsic/impurity defect states (such as acceptor Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Cd</sub> and donor Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> in CdTe), the concept of transformation of state and self-compensation is introduced and discussed. The effect of state transformation and self-compensation on charge neutrality condition, Fermi level, and majority carrier density is explored. Numerical examples are given for CdTe to illustrate the relevance and importance of multi-level and multi-configuration intrinsic/impurity defect states for understanding the performance of CdTe thin film photovoltaics (PV).
Comparison of the damping properties of different strip steels at different frequencies. (2018)

The flapper valve is one of the most critical components of the reciprocating compressor. During the compressor’s service lifetime, the flapper valve has to open and close billions of times without failure or maintenance. Smooth and efficient operation of the compressors not only requires an optimized design of the valve but it also places high demands on its material. Material damping of the flapper valves in the reciprocating compressors positively influences the flapper valve operation by directly reducing the magnitude of the induced stress waves in the valve reeds. It has also been reported in several studies that material damping reduces the amplitude of fatigue stresses in components or specimens subjected to fatigue load conditions. The current study presents an investigation of the material damping properties of a range of hardened and tempered martensitic steels including the new flapper valve steel grade, Flap-X, developed by voestalpine Precision Strip AB. The tested materials included three flapper valve steel grades Flap-X, AISI 420 (SS716) and AISI 1095 (20C) along with two other thin strip materials: the S-Coat L+ tool steel and 13Cr 0.7C martensitic stainless steel grade known as UHB AEB-L. Material damping was measured using impulse excitation apparatus that measured the resonant frequencies and the loss rate of vibrations in the flexural mode in order to evaluate the material damping parameter (Q-1) at room temperature. Different frequencies were investigated in this study ranging from 50 Hz to approximately 10 kHz for all the tested materials. The measured material damping data for the tested materials showed that damping decreased with increasing frequency above 50 Hz up to around 2000 Hz and then stabilized until approximately 9000Hz. Material damping for the Flap-X grade was found to be higher than the SS 716 grade at all the measured frequencies and higher than all the tested grades at ~9000 Hz. The material damping of the 20 C grade was found to be the highest at 50 Hz while the UHB AEB-L grade displays the highest damping at 250 Hz and 2000 Hz. In addition, an attempt has been successfully made to fit the Rayleigh damping model to the obtained damping data. These results have significant implications for the impact fatigue stresses in the valves, their impact fatigue life and the noise levels they contribute to in the reciprocating compressors.