gebhart/patrepeval huggingface dataset:
CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins (2014)

Mitochondrial function requires coordination of two genomes for protein biogenesis, efficient quality control mechanisms, and appropriate distribution of the organelles within the cell. How these mechanisms are integrated is currently not understood. Loss of the Clu1/CluA homologue (CLUH) gene led to clustering of the mitochondrial network by an unknown mechanism. We find that CLUH is coregulated both with genes encoding mitochondrial proteins and with genes involved in ribosomal biogenesis and translation. Our functional analysis identifies CLUH as a cytosolic messenger ribonucleic acid (RNA; mRNA)-binding protein. RNA immunoprecipitation experiments followed by next-generation sequencing demonstrated that CLUH specifically binds a subset of mRNAs encoding mitochondrial proteins. CLUH depletion decreased the levels of proteins translated by target transcripts and caused mitochondrial clustering. A fraction of CLUH colocalizes with tyrosinated tubulin and can be detected close to mitochondria, suggesting a role in regulating transport or translation of target transcripts close to mitochondria. Our data unravel a novel mechanism linking mitochondrial biogenesis and distribution.
Parametric modeling of edge effects for polishing tool influence functions (2009)

Computer controlled polishing requires accurate knowledge of the tool influence function (TIF) for the polishing tool (i.e. lap). While a linear Preston's model for material removal allows the TIF to be determined for most cases, nonlinear removal behavior as the tool runs over the edge of the part introduces a difficulty in modeling the edge TIF. We provide a new parametric model that fits 5 parameters to measured data to accurately predict the edge TIF for cases of a polishing tool that is either spinning or orbiting over the edge of the workpiece.
Temporal association between zolpidem medication and the risk of suicide: A 12-year population-based, retrospective cohort study (2020)

There have been concerns about abuse and unnecessary chronic administration of zolpidem, and zolpidem's relation to suicide risk. To investigate the temporal association of zolpidem with the risk of suicide, we conducted a 12-year, population-based, retrospective cohort study on the National Health Insurance Service-National Sample Cohort (NHIS-NSC), South Korea. Data were collected from 2002 to 2013 from the NHIS-NSC, and data cleaning was performed for 1,125,691 subjects. Cox proportional hazards regression analysis was used to investigate the correlation over time between zolpidem medication and suicide. Over intervals commencing after 80 months of observation, the adjusted hazard ratio of suicides associated with the use of the zolpidem was 2.01 (95% CI: 1.58-2.56; p < 0.001). The mean cumulative number of days of zolpidem prescription was significantly longer in the suicide group than in the non-suicide group after log-transformation (p = 0.005). Cases of chronic use of zolpidem (over six months or one year) were significantly more common in the suicide group compared to the non-suicide group (p = 0.002 and 0.005, respectively). Subjects who received zolpidem medication had a significantly higher risk of suicide after at least 80 months of observation, suggesting a long-term increased suicide risk associated with insomnia exposed to zolpidem medication.
Non-linear luminescent coupling in series-connected multijunction solar cells (2012)

The assumption of superposition or linearity of photocurrent with solar flux is widespread for calculations and measurements of solar cells. The well-known effect of luminescent coupling in multijunction solar cells has also been assumed to be linear with excess current. Here we show significant non-linearities in luminescent coupling in III-V multijunction solar cells and propose a simple model based on competition between radiative and nonradiative processes in the luminescent junction to explain these non-linearities. We demonstrate a technique for accurately measuring the junction photocurrents under a specified reference spectrum, that accounts for and quantifies luminescent coupling effects.
Design and Implementation of UPS Base on Embedded Operating System (2013)

Describe a firm ware implementation strategy of on-line UPS digital control system which transplants an embedded operating system on DSP56F8356.The structure of single input and singe output on-line UPS firm ware is presented.The function of every task and interrupt service subroutine is deeply discussed.Program under this firmware structure has run on a 10KVA online UPS.The experiment result shows that each specification of UPS meets national standard and is leading the way of UPS industry.
Manipulation and Counter-Framing: A Content Analysis of Media's Response to the Anti-communist Movements in 1990 Romania (2012)

The purpose of the present article is to demonstrate the importance of counter-framing for the outcome of social movements. To do so, I focus on a particular case, namely Romanian society during the first half of 1990. The research identifies some strategies of the ruling group to create and impose their own framework and to align it with the interests of the people. It is based on content analysis of a Romanian daily newspaper faithful to the government, employing grounded theory as the method of research. The analysis highlights several relevant categories, grouped under two main subsections: creating an unfavorable public image of the protest movement, and creating an unfavorable public image of the opposition's leaders.
Sesquiterpene lactones as drugs with multiple targets in cancer treatment (2012)

Sesquiterpene lactones (SLs) constitute a large and diverse group of biologically active plant compounds that possess anti-inflammatory and antitumor activity. The subclass germacranolides is one of the major groups of SLs. It includes parthenolide, a highly cytotoxic SL that is being tested in clinical trials as an anti-cancer agent. In this review, we focus on SL antitumor activity related to cell-cycle arrest, differentiation, apoptosis induction through the intrinsic pathway, and sensitization of the extrinsic pathway. We also address the regression of tumors in response to cotreatment with conventional chemotherapeutics. We review the nuclear factor-κB-targeted anti-inflammatory activity in vitro and in vivo and relate it to the SL structural features involved in the molecular mechanisms. It is obvious that SLs are emerging as promising anticancer agents, but more investigations are required to fully understand the molecular mechanisms of known SLs in different cell death modalities and how these mechanisms contribute toward the potent antitumor and anti-inflammatory activities of SLs.
Polyphase IIR decimation filter design for oversampled A/D converters with approximately linear phase (1992)

The authors describe a polyphase IIR decimation filter design methodology for oversampled A/D converters by formulating a general nonlinear programming problem that optimizes magnitude response under certain phase linearity constraints. It provides the flexibility of maximizing the signal-to-noise (SNR) when quantization noise with an arbitrary spectral density is presented. A numerical method, the samples-sum-estimation (SSE) method, is introduced to simplify the objective function. Examples show that the proposed design enjoys at least a factor of two reduction in the multiplication rate when compared with conventional FIR filters. This implementation becomes more attractive for applications in modulators with multibit output such as the MASH modulator as well as Sigma - Delta modulators with a multibit internal quantizer. The proposed design achieves a SNR of less than 1 dB from that obtained with an ideal low-pass filter at different decimation ratios while the group delay displays an approximately constant value.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Control of Serum Lipids with Soy Protein (1995)

Since the beginning of the century, evidence of the cholesterol-lowering properties of dietary proteins of plant origin has been accumulating.1 These effects, particularly of soy proteins, have repeatedly been observed in carefully controlled animal models of hypercholesterolemia.2 Numerous trials in humans have attempted to reproduce the promising observations in animals, but most studies have included too few participants and have lacked the statistical power necessary to detect the effects of dietary intervention. This lack of statistically significant effects led the Nutrition Committee of the American Heart Association to conclude in 1993 that soy protein did not have hypocholesterolemic effects in . . .
A new method for accessing documents in environments with limited connection speed, storage and screen space (2003)

A new system is presented for accessing remote document (ARD) in a limited computing environment. It provides mobile device (PDA, HPC and PPC) users with the ability to easily access remote documents over the Internet and to quickly view the content with its original look and feel without downloading and further to print or fax the document on a remote printer over the Internet. This is achieved through the combination of the unique document streaming-on-demand mechanism and the ability to preserve the original look and feel, and off-the-shell products that support Internet printing services. We describe in detail how the challenging issues are addressed and how the system is implemented.
DEVELOPMENT OF REAL‐TIME ENDOSCOPIC IMAGE PROCESSING TECHNOLOGY: ADAPTIVE INDEX OF HEMOGLOBIN COLOR ENHANCEMENT PROCESSING (2002)

A depressing type of early cancer has recently been focused on. From the endoscopy point of view, it is said that this type of cancer can be identified with change in color tone such as reddening or discoloration. With the structural enhancement processing incorporated into EVIP‐230 and CV‐240, mucosal minute patterns can be made clear by the enhancement processing; however, in theory, this is not regarded as being suitable to enhance slight difference of color tone itself. In addition, even if the number of pixels of the CCD is increased and resolution is improved, it is not likely that slight color tone change is made clear. However, with the index of hemoglobin (IHb) color enhancement processing incorporated into EVIP‐230 the following improvements have been made. 1. Red component of the image is easily saturated. 2. Because of the enhancement processing, noise becomes noticeable at dark part, and halation is likely to be seen at light part. In order to solve the above problems and realize the best enhancement processing for endoscopic images, we developed the adaptive IHb color enhancement processing system which performs the most suitable enhancement processing adaptively according to condition of each image and each pixel.
Electrical impedance tomography using induced and injected currents (1992)

A two-dimensional forward problem formulation is introduced for electrical impedance tomography (EIT) using induced currents. The forward problem is linearised around a certain resistivity distribution and the inverse problem is formulated as a solution of a linear system of equations. Sensitivity of boundary measurements to resistivity variations are analysed for spatially uniform, linear and quadratic fields. The formulation, however, is suitable for studying the effects of a general magnetic field applied to induce the currents in the conductive object. A similar inverse problem formulation is also developed for EIT using injected currents. Simulation studies are performed by reconstructing images of a simulation distribution using both methods separately with generalised inversion. It is also shown that the derived formulations for the inverse problems of the two methods can be combined to solve a larger set of equations with a greater number of independent measurements.
Potential applications of ferulic acid from natural sources (2014)

Ferulic acid (FA), a ubiquitous natural phenolic phytochemical present in seeds, leaves, bothin its free form and covalently conjugated to the plant cell wall polysaccharides, glycoproteins,polyamines, lignin and hydroxy fatty acids. FA plays a vital role in providing the rigidity to the cell wall and formation of other important organic compounds like coniferyl alcohol, vanillin, sinapic, diferulic acid and curcumin. FA exhibits wide variety of biological activities such as antioxidant, antiinflammatory, antimicrobial, antiallergic, hepatoprotective, anticarcinogenic, antithrombotic, increase sperm viability, antiviral and vasodilatory actions, metal chelation, modulation of enzyme activity, activation of transcriptional factors, gene expression and signal transduction.
Sub-kT/q subthreshold slope p-metal-oxide-semiconductor field-effect transistors with single-grained Pb(Zr,Ti)O3 featuring a highly reliable negative capacitance (2016)

A reliable on/off switching with an sub-kT/q subthreshold slope (38 mV/dec at room temperature) is experimentally demonstrated with using selectively nucleated laterally crystallized single-grain Pb(Zr,Ti)O3 (PZT) ferroelectric and ZrTiO4 paraelectric thin-film. The combination of ferroelectric and paraelectric thin-film is enabled to form a negative capacitance (NC) at the weak inversion region. However, the PZT grain-boundary easily degrades the NC properties after switching the on/off more than 108 times. It is found that the polarization of PZT is diminished from the path of grain-boundary. Here, we effectively suppress the degradation of NC MOS-FET which did not showed any fatigue even after 108 on/off switching. At the request of the authors this article is retracted due to duplication of figures and significant overlap with other publications by the authors and because of concerns about the accuracy of the description of the devices and materials from which the reported results were obtained. The authors recognize that these represent serious errors and sincerely apologize for any inconvenience they may have caused. The article is retracted from the scientific record with effect from 17 February 2017.
Experimental evidence for mobile luminescence center mobility on partial dislocations in 4H-SiC using hyperspectral electroluminescence imaging (2013)

We report on the formation, motion, and concentration of localized green emission centers along partial dislocations (PDs) bounding recombination-induced stacking faults (RISFs) in 4H-SiC pin diodes. Electroluminescence imaging depicted the motion of these green emitting point defects during forward bias operation along carbon-core PDs that bound the RISFs. Following high temperature annealing, these green emitting point defects did not contract with the PDs, but remained in the final location during the expansion. This implies that the motion of these green emitting point dislocations is enabled through a recombination-enhanced motion, similar to the process for RISF expansion and contraction within SiC.
DisruptingTP53 in mouse models of human cancers (2003)

Manipulation of the mouse genome allows emulation of the genetic defects that give rise to human cancers and evaluation of the cooperating nature of different mutations in the transformation of distinct cell types. Here we review the generation of mice with specific missense mutations in p53 (TP53) and disruption of the p53 pathway by deletion of p53 inhibitors. Missense mutations in the DNA binding domain result in viable mice with gain-of-function and dominant negative phenotypes. Loss of either of the p53 inhibitors mdm2 or mdm4 gives rise to a p53-dependent embryonic lethal phenotype. A cell can thus tolerate the absence of p53 function but not excess p53 function, a characteristic that is being exploited in the treatment of human cancers.
Demonstrating a System for Efficient and Sustainable Road Freight Based on Dynamic Power Supply (2016)

To meet the new constraints faced by road freight in terms of significantly lowering or reducing CO2 emissions, high fuel costs and improved air quality an Electric Road System (ERS), based on an Overhead Contact Line (OCL)-hybrid heavy duty vehicle (HDV), has been designed, developed, tested and demonstrated. The ERS demonstrated has twice the energy efficiency of conventional diesel HDVs and enables the use of renewable energy. The technological development was made possible by combining expertise from rail electrification, electric drives and a newly developed active current collector for dynamically connecting to the OCL and receiving a continuous supply of electricity to power the vehicle’s engine and to store energy onboard. The research project demonstrated that a hybrid truck can run in pure electric mode without any change in the operations for the driver and without any concessions on truck performance. The ERS infrastructure was successfully integrated into a highway environment, e.g. adjusting for low clearances and road signs. The result was the first fully operable prototype on a test track with dedicated infrastructure. Since mid-2011 it has been undergoing testing and demonstration. During trials, the OCLhybrid prototypes demonstrated full performance and suitability for everyday use – regardless of the environmental and load conditions. In addition to providing highly promising results in terms of technology, the tests also demonstrated benefits to the environment and economy. The ERS combines the technology of the road with the technology of the vehicle to form one system. It can be integrated with existing infrastructure, thus making it much easier and cheaper to implement and maintain. Lower energy consumption yields lower operating costs and the resulting savings can finance the infrastructure investment, especially on heavily trafficked routes, such as port-to-rail connections near metropolitan areas. These aspects will be further demonstrated on public road projects in Sweden and California, with operations commencing in the first half of 2016. This paper presents the latest available results and points the way to a heavy duty road freight system with full electric power and full flexibility.
Evidence indicating that inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein or by 25-hydroxycholesterol requires mediator protein(s) with rapid turnover rate. (1981)

The half-life (t 1/2) of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase of Chinese hamster ovary cells grown in fetal calf serum medium is approximately 2 h. When cells are switched to grow in delipidated serum medium (DeL-M) for more than 24 h, the t 1/2 of the enzyme is found to be drastically altered to approximately 13 h. Exposure of low density lipoprotein (LDL) (100 micrograms of protein/ml) or 25-hydroxycholesterol (1 microgram/ml) to cells grown in DeL-M suppresses reductase activity more rapidly than would be expected solely if reductase synthesis were suppressed, showing that inactivation of reductase activity by sterols, previously demonstrated using only analogs of cholesterol, is a normal mechanism for regulation of HMG-CoA reductase activity by the physiologically important sterol source (LDL). This inactivation effect by LDL or by 25-hydroxycholesterol is shown to be at least in part due to acceleration of reductase degradation rate. Furthermore, the inactivation effect by sterols is shown to be largely abolished if cycloheximide (250 micrograms/ml) is added simultaneously to the growth medium, indicating that continuous synthesis of a class of mediator protein(s) is necessary in mediating the effect of LDL or 25-hydroxycholesterol. Two different protein synthesis inhibitors (emetine and puromycin) were used and gave essentially identical results. Preincubation of cell culture with cycloheximide for 2 h essentially completely abolishes the effect of 25-hydroxycholesterol, indicating that the mediator protein(s) turns over rapidly, with t 1/2 less than 3 or 4 h.
Multistep Prediction of Physiological Tremor Based on Machine Learning for Robotics Assisted Microsurgery (2014)

For effective tremor compensation in robotics assisted hand-held device, accurate filtering of tremulous motion is necessary. The time-varying unknown phase delay that arises due to both software (filtering) and hardware (sensors) in these robotics instruments adversely affects the device performance. In this paper, moving window-based least squares support vector machines approach is formulated for multistep prediction of tremor to overcome the time-varying delay. This approach relies on the kernel-learning technique and does not require the knowledge of prediction horizon compared to the existing methods that require the delay to be known as a priori. The proposed method is evaluated through simulations and experiments with the tremor data recorded from surgeons and novice subjects. Comparison with the state-of-the-art techniques highlights the suitability and better performance of the proposed method.
Tumor Characteristics and Clinical Outcome of Elderly Women With Breast Cancer (2000)

In women 55 years old or older, advancing age is associated with more favorable tumor biology, and breast cancer survival in older women is similar to survival in the general population irrespective of disease status. This favorable outcome should be considered when making clinical decisions in older patients.
Optical Properties Of Mixed Silver Halide Crystals And Polycrystalline Optical Fibers (1989)

The spectral window of mixed AgClxBr1-x (0≤x≤1) crystals and polycrystalline fibers was investigated as a function of composition. Both visible edge, resulting from electronic transitions, and infrared edge due to multiphonon processes, behave as the one-mode (amalgamation) type of mixed crystals, shifting continuously with composition. The extruded polycrystalline optical fibers preserve the spectral window of silver-halide crystals. Deviations which slightly broaden the window in the infrared regime are explained by the fibers small-grain structure.
Potent Inhibitors of β-Tryptase and Human Leukocyte Elastase Based on the MCoTI-II Scaffold (2009)

MCoTI-II is a member of a class of microproteins known as cyclotides that possess a macrolactam-cystine knot scaffold imparting exceptional physiological stability and structural rigidity. Modification of residues in the active loop and engineered truncations have resulted in MCoTI-II analogues that possess potent activity against two therapeutically significant serine proteases: beta-tryptase and human leukocyte elastase. These results suggest that MCoTI-II is a versatile scaffold for the development of protease inhibitors against targets in inflammatory disease.