gebhart/patrepeval huggingface dataset:
Activation of Clotting Factors in Thrombocytopenia Due to Platelets Destruction: A Possible Compensated Mechanism for Hemostasis. (2005)

Abstract INTRODUCTION. Thrombocytopenia (TP) due to bone marrow failure, as in aplastic anemia (AA), is often associated with frequent and fatal bleeding, whereas fatal bleeding in TP due to platelet destruction, as in ITP, is rare. It has been suggested that giant platelets or increased cell-derived microparticles (MP) act to limit bleeding in ITP. We investigated clotting factors and MP from 3 cell types, platelets (PMP), leukocytes (LMP), and endothelial (EMP), in patients with different causes of their TP. METHODS. Group 1 (platelet destruction) consisted of 2 subgroups, Grp 1a having n=35 pts with active ITP (ITP-A) and Grp 1b having n=15 pts with platelet destruction (PD) by other disorders (TTP, PNH, others). Group 2 (impaired production (IP)) consisted of n=19 pts with AA, MDS/MPD, and others. Group 3 comprised n=28 pts with ITP in remission (ITP-R). Laboratory measures included CBC, platelets, FVIII, FIX, FXI, and 3 kinds of MP: PMP, LMP, EMP. Signs and symptoms of bleeding were graded and recorded. RESULTS. Key data is summarized in Table 1. The percentage of patients with elevated activity of FVIII was significantly more prevalent in Grp 1a vs. Grp 3 (53% vs. 15%, p=0.002) or Grp 1b vs. Grp 2 (73% vs. 11%, p=0.0002). The mean value of FVIII titer was also significantly higher in Grp 1a vs. Grp 3 (1.92 vs. 1.33 U/mL, p=0.0036) or Grp 1b vs. Grp 2 (2.44 vs. 1.18 U/mL, p=0.00007). The mean percentage of patients with elevated FIX or FXI, or the mean value of FIX or FXI titer were also higher in Grp 1a vs. Grp 3 or Grp 1b vs. Grp 2, but the difference did not reach statistical significance. PMP counts were found to correlate with platelet counts in all groups, and were significantly higher in Grp 3 than Grp 1a (p=0.0004). Grp 3 also had higher EMP than Grp 1a (p=0.04). LMP showed no significant differences. REPRESENTATIVE CASE. A patient with chronic ITP who relapsed with severe acute ITP was monitored sequentially. In acute phase of TP, activities of FVIII, FIX, and FXI surged, in parallel with shortening of aPTT, and patient had minimal signs of bleeding. Serial assays revealed gradual fall of factor activities, reaching normal levels after 5 months. A similar pattern was observed in another patient, with acute TTP: clotting factors returned to normal after 2 months. CONCLUSION. TP due to platelet destruction appears to trigger activation of intrinsic clotting pathway which may protect from excessive bleeding. Surge in FVIII was most notable. This compensation effect appears to be absent in TP due to depressed platelet production, and likewise for ITP in remission. The mechanism underlying this phenomenon remains to be elucidated. Further study is in progress to delineate the mechanism. Table 1 Grp1a (ITP-A) Grp1b (PD) Grp2 (IP) Grp3 (ITP-R) p value p value Number 35 15 19 28 1a vs 3 1b vs 2 FVIII (%) 53 73 11 15 0.002 0.0002 FIX (%) 19 27 6 13 NS NS FXI (%) 16 14 0 8 NS NS PMP 8315 15531 9768 17085 0.0004 NS EMP 328 325 393 578 0.04 NS LMP 1388 1230 1255 1486 NS NS
Symbiotic Performance of Supernoclulating Soybean (<i>Glycine max</i>(L.) Merrill) Mutants during Development on Different Nitrogen Regimes (1989)

Growth and symbiotic performance of soybean (Glycine max (L.) Merrill) cv. Bragg and three of its induced nodulation mutants (nod49, non-nodulating; ntsl 116, intermediate supernodulator; nts1007, extreme supernodulator) were compared throughout development under different nitrogen regimes (0, 2, 5 and 10 mol nitrate m−3). Nitrogen fixation was assessed using 15N-isotope dilution and xylem sap analysis for ureide content. Both techniques confirmed a complete lack of N2 fixation activity in nod49. Plant reliance on nitrogen fixation by the other genotypes was dependent on the nitrate regime and the developmental stage. The ntsl007 and ntsl 116 mutants fixed more nitrogen than the parent cultivar in the presence of 10 mol m−3 nitrate in the nutrient solution, but higher input of symbiotically derived nitrogen was still insufficient to offset the amount of nitrogen removed in the harvested seed. However, the mutants utilized less nitrate for growth than Bragg. Comparison of estimates of N2 fixation derived from the 15N-dilution technique with those based on relative ureide content of xylem sap indicated that the latter offered a simple and reliable procedure for evaluating the symbiotic performance of supernodulating plants.
Recent advances in semiconductors for photocatalytic and photoelectrochemical water splitting (2014)

Photocatalytic and photoelectrochemical water splitting under irradiation by sunlight has received much attention for production of renewable hydrogen from water on a large scale. Many challenges still remain in improving energy conversion efficiency, such as utilizing longer-wavelength photons for hydrogen production, enhancing the reaction efficiency at any given wavelength, and increasing the lifetime of the semiconductor materials. This introductory review covers the fundamental aspects of photocatalytic and photoelectrochemical water splitting. Controlling the semiconducting properties of photocatalysts and photoelectrode materials is the primary concern in developing materials for solar water splitting, because they determine how much photoexcitation occurs in a semiconductor under solar illumination and how many photoexcited carriers reach the surface where water splitting takes place. Given a specific semiconductor material, surface modifications are important not only to activate the semiconductor for water splitting but also to facilitate charge separation and to upgrade the stability of the material under photoexcitation. In addition, reducing resistance loss and forming p-n junction have a significant impact on the efficiency of photoelectrochemical water splitting. Correct evaluation of the photocatalytic and photoelectrochemical activity for water splitting is becoming more important in enabling an accurate comparison of a number of studies based on different systems. In the latter part, recent advances in the water splitting reaction under visible light will be presented with a focus on non-oxide semiconductor materials to give an overview of the various problems and solutions.
IDO2 (indoleamine 2,3-dioxygenase 2) (2011)

Review on IDO2 (indoleamine 2,3-dioxygenase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Detection and transmission in chimpanzees of hepatitis B virus-related agents formerly designated "non-A, non-B" hepatitis. (1982)

Four chimpanzees have been infected with three different inocula containing "non-A, non-B" hepatitis virus(es). After inoculation, serial studies established the presence of antigenemia or viremia (or both) by radioimmunoassay with high-affinity monoclonal antibodies directed toward separate and distinct determinants on hepatitis B surface antigen (HBsAg) and by molecular hybridization analysis using a cloned hepatitis B virus (HBV) DNA probe. In contrast to results observed during HBV infection, elevations in serum alanine aminotransferase values indicate that liver injury preceded antigenemia by several weeks. Thus, the time between inoculation and development of antigenemia (incubation period) varied from 64 to 190 days and, in some cases, single or multiple episodes of antigenemia or viremia occurred in the absence of elevated aminotransferase levels. In this study, two chimpanzees were high-titer positive for antibodies to HBsAg (anti-HBs) from previous infection with HBV, suggesting that the antigenic composition of HBV-related virus(es) is substantially different from that of HBV, since naturally occurring anti-HBs antibodies were not protective. Demonstration of HBV-related virus(es) by the methods used in this study of experimental hepatitis infection in chimpanzees should now permit detection, isolation, and characterization of these previously elusive agents.
Passive Phase Noise Cancellation Scheme (2012)

We introduce a new method for reducing phase noise in oscillators, thereby improving their frequency precision. The noise reduction is realized by a passive device consisting of a pair of coupled nonlinear resonating elements that are driven parametrically by the output of a conventional oscillator at a frequency close to the sum of the linear mode frequencies. Above the threshold for parametric instability, the coupled resonators exhibit self-oscillations which arise as a response to the parametric driving, rather than by application of active feedback. We find operating points of the device for which this periodic signal is immune to frequency noise in the driving oscillator, providing a way to clean its phase noise. We present results for the effect of thermal noise to advance a broader understanding of the overall noise sensitivity and the fundamental operating limits.
Moving sources detection system (2013)

To monitor radioactivity passing through a pipe or in a given container such as a train or a truck, radiation detection systems are commonly employed. These detectors could be used in a network set along the source track to increase the overall detection efficiency. However detection methods are based on counting statistics analysis. The method usually implemented consists in trigging an alarm when an individual signal rises over a threshold initially estimated in regards to the natural background signal. The detection efficiency is then proportional to the number of detectors in use, due to the fact that each sensor is taken as a standalone sensor. A new approach is presented in this paper taking into account the temporal periodicity of the signals taken by all distributed sensors as a whole. This detection method is not based only on counting statistics but also on the temporal series analysis aspect. Therefore, a specific algorithm is then developed in our lab for this kind of applications and shows a significant improvement, especially in terms of detection efficiency and false alarms reduction. We also plan on extracting information from the source vector. This paper presents the theoretical approach and some preliminary results obtain in our laboratory.
Molecular Characterization of a Thermophilic Endo-polygalacturonase from <i>Thielavia arenaria</i> XZ7 with High Catalytic Efficiency and Application Potential in the Food and Feed Industries (2014)

Thermophilic endo-polygalacturonases with high catalytic efficiency are of great interest in the food and feed industries. This study identified an endo-polygalacturonase gene (pg7fn) of glycoside hydrolase family 28 in the thermophilic fungus Thielavia arenaria XZ7. Recombinant PG7fn produced in Pichia pastoris is distinguished from other enzyme counterparts by its high functional temperature (60 °C) and specific activity (34382 ± 351 U/mg toward polygalacturonic acid). The enzyme exhibited good pH stability (pH 3.0-8.0) and resistance to pepsin and trypsin digestion and had a significant effect on disaggregation of soybean meal. Addition of 1 U/g PG7fn increased the pectin bioavailability by 19.33%. The excellent properties described above make PG7fn valuable for applications in the food and feed industries. Furthermore, a comparative study showed that N-glycosylation improved the thermostability and catalytic efficiency of PG7fn.
Properties of Magnesium Alloy with Mg_2Si/MgO dispersions via Solid-state Synthesis (2002)

Magnesium usually has thermally stable oxide films on its surface, which can be broken by the mechanical force. The hardening phase of Mg_2Si is successfully synthesized by the solid-state reaction between Mg and SiO_2 powder on the route of hot forging and hot extrusion. The result indicates that hot extrusion is benefit to obtain fine and homogenous Mg_2Si/MgO dispersions in the Mg matrix. Comparing with that performed by hot forging, the Mg_2Si/MgO/Mg composite by hot extrusion shows superior mechanical properties.
Gene Clusters for Insecticidal Loline Alkaloids in the Grass-Endophytic Fungus Neotyphodium uncinatum (2005)

Loline alkaloids are produced by mutualistic fungi symbiotic with grasses, and they protect the host plants from insects. Here we identify in the fungal symbiont, Neotyphodium uncinatum, two homologous gene clusters (LOL-1 and LOL-2) associated with loline-alkaloid production. Nine genes were identified in a 25-kb region of LOL-1 and designated (in order) lolF-1, lolC-1, lolD-1, lolO-1, lolA-1, lolU-1, lolP-1, lolT-1, and lolE-1. LOL-2 contained the homologs lolC-2 through lolE-2 in the same order and orientation. Also identified was lolF-2, but its possible linkage with either cluster was undetermined. Most lol genes were regulated in N. uncinatum and N. coenophialum, and all were expressed concomitantly with loline-alkaloid biosynthesis. A lolC-2 RNA-interference (RNAi) construct was introduced into N. uncinatum, and in two independent transformants, RNAi significantly decreased lolC expression (P < 0.01) and loline-alkaloid accumulation in culture (P < 0.001) compared to vector-only controls, indicating involvement of lolC in biosynthesis of lolines. The predicted LolU protein has a DNA-binding site signature, and the relationships of other lol-gene products indicate that the pathway has evolved from various different primary and secondary biosynthesis pathways.
Non-contrast enhanced pulmonary vein MRI with a spatially selective slab inversion preparation sequence (2010)

We propose a non-contrast-enhanced, three-dimensional, free-breathing, electrocardiogram-gated, gradient recalled echo sequence with a slab-selective inversion for pulmonary vein (PV) MRI. A sagittal inversion slab was applied prior to data acquisition to suppress structures adjacent to the left atrium (LA) and PVs, thereby improving the conspicuity of the PV and LA. Compared with other MR angiography methods using an inversion pulse, the proposed method does not require signal subtraction and the inversion slab is not parallel to the imaging slab. The feasibility of the proposed method was demonstrated in healthy subjects. The inversion slab thickness and inversion time were optimized to be 60 mm and 500 ms, respectively. Compared to conventional gradient recalled echo imaging without inversion, the proposed technique significantly increased the contrast-to-noise ratios between the LA and the right atrium by 20-fold (P 0.3). The proposed technique greatly enhances the conspicuity of the PVs and LA without significant loss of signal-to-noise ratio.
Enzymatically activated microencapsulated liposomes can provide pulsatile drug release (1990)

A system for the delayed or pulsed release of biologically active substances was achieved by encapsulating liposomes containing the substance of interest inside microcapsules. The microcapsules retain the liposomes but allow controlled diffusion of the active substance when it is released from the liposomes. Furthermore, by coating the liposomes with phospholipase A2 (an enzyme that removes an acyl group from the 2 position of phospholipids) before placing them within the microcapsule, a pulsatile release pattern was achieved both in vitro and in vivo. The time of onset of the pulse as well as the release rate can be controlled by the amount of phospholipase A2, the molecular weight of the poly(L-lysine) that is used to coat the microencapsulated liposomes, and the composition of the phospholipid bilayer membrane. Even at 37 degrees C the system would protect a model enzyme (horseradish peroxidase). When not placed inside the microencapsulated liposomes, the enzyme lost its activity in solution at 37 degrees C in a few days, whereas it retained 40% of the initial activity after 30 days of incubation at 37 degrees C inside the microencapsulated liposomes.
Human hepatic stem cells from fetal and postnatal donors (2007)

Human hepatic stem cells (hHpSCs), which are pluripotent precursors of hepatoblasts and thence of hepatocytic and biliary epithelia, are located in ductal plates in fetal livers and in Canals of Hering in adult livers. They can be isolated by immunoselection for epithelial cell adhesion molecule-positive (EpCAM+) cells, and they constitute approximately 0.5-2.5% of liver parenchyma of all donor ages. The self-renewal capacity of hHpSCs is indicated by phenotypic stability after expansion for >150 population doublings in a serum-free, defined medium and with a doubling time of approximately 36 h. Survival and proliferation of hHpSCs require paracrine signaling by hepatic stellate cells and/or angioblasts that coisolate with them. The hHpSCs are approximately 9 microm in diameter, express cytokeratins 8, 18, and 19, CD133/1, telomerase, CD44H, claudin 3, and albumin (weakly). They are negative for alpha-fetoprotein (AFP), intercellular adhesion molecule (ICAM) 1, and for markers of adult liver cells (cytochrome P450s), hemopoietic cells (CD45), and mesenchymal cells (vascular endothelial growth factor receptor and desmin). If transferred to STO feeders, hHpSCs give rise to hepatoblasts, which are recognizable by cordlike colony morphology and up-regulation of AFP, P4503A7, and ICAM1. Transplantation of freshly isolated EpCAM+ cells or of hHpSCs expanded in culture into NOD/SCID mice results in mature liver tissue expressing human-specific proteins. The hHpSCs are candidates for liver cell therapies.
An error free passive UHF RFID system using a new form of wireless signal distribution (2012)

A wide area and error free ultra high frequency (UHF) radio frequency identification (RFID) interrogation system based on the use of multiple antennas used in cooperation to provide high quality ubiquitous coverage, is presented. The system uses an intelligent distributed antenna system (DAS) whereby two or more spatially separated transmit and receive antenna pairs are used to allow greatly improved multiple tag identification performance over wide areas. The system is shown to increase the read accuracy of 115 passive UHF RFID tags to 100% from <;60% over a 10m × 8m open plan office area. The returned signal strength of the tag backscatter signals is also increased by an average of 10dB and 17dB over an area of 10m × 8m and 10m × 4m respectively. Furthermore, it is shown that the DAS RFID system has improved immunity to tag orientation. Finally, the new system is also shown to increase the tag read speed/rate of a population of tags compared with a conventional RFID system.
Catalytically Active Bacterial Nanocellulose‐Based Ultrafiltration Membrane (2018)

Large quantities of highly toxic organic dyes in industrial wastewater is a persistent challenge in wastewater treatment processes. Here, for highly efficient wastewater treatment, a novel membrane based on bacterial nanocellulose (BNC) loaded with graphene oxide (GO) and palladium (Pd) nanoparticles is demonstrated. This Pd/GO/BNC membrane is realized through the in situ incorporation of GO flakes into BNC matrix during its growth followed by the in situ formation of palladium nanoparticles. The Pd/GO/BNC membrane exhibits highly efficient methylene orange (MO) degradation during filtration (up to 99.3% over a wide range of MO concentrations, pH, and multiple cycles of reuse). Multiple contaminants (a cocktail of 4-nitrophenol, methylene blue, and rhodamine 6G) can also be effectively treated by Pd/GO/BNC membrane simultaneously during filtration. Furthermore, the Pd/GO/BNC membrane demonstrates stable flux (33.1 L m<sup>-2</sup> h<sup>-1</sup> ) under 58 psi over long duration. The novel and robust membrane demonstrated here is highly scalable and holds a great promise for wastewater treatment.
Simulation and Fabrication of Silicon Micro-Grippers Actuated by Piezoelectric Actuator (2005)

The eight types of micro-grippers with silicon were simulated by ANSYS and fabricated by MEMS(Micro Electro Mechanical System) process. Each type of micro-grippers had a small difference in design shape such as beam width, gap between beams. In order to modify design shape, these micro-grippers were estimated and simulated in point of structure, actuation characteristics by changing design factors. Micro-grippers were composed of five parts which were piezoelectric actuation part, fixing part, rotation arms, the block and gripping jaws. The shape of gripping jaws was designed as the teeth of a saw to reduce adhesion force by decreasing the contact area. The 10.2 µm movement by piezoelectric actuator at 120 V generated the 142.8 µm gripping range of a micro-gripper in real measurement. In the case of simulation result, the gripping range of 162 µm was generated at the same condition. This gripping range was enough to handle small objects like micro-parts
Reconstructing patient-specific cardiac models from contours via Delaunay triangulation and graph-cuts (2013)

This study proposes a novel method to reconstruct the left cardiac structure from contours. Given the contours representing left ventricle (LV), left atrium (LA), and aorta (AO), re-orientation, contour matching, extrapolation, and interpolation are performed sequentially. The processed data are then reconstructed via a variational method. The weighted minimal surface model is revised to handle the multi-phase cases, which happens at the LV-LA-AO junction. A Delaunay-based tetrahedral mesh is generated to discretize the domain while the max-flow/min-cut algorithm is utilized as the minimization tool. The reconstructed model including LV, LA, and AO structure is extracted from the mesh and post-processed further. Numerical examples show the robustness and effectiveness of the proposed method.
ZSM-5-type materials. Factors affecting crystal symmetry (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTZSM-5-type materials. Factors affecting crystal symmetryE. L. Wu, S. L. Lawton, D. H. Olson, A. C. Rohrman, and G. T. KokotailoCite this: J. Phys. Chem. 1979, 83, 21, 2777–2781Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://pubs.acs.org/doi/10.1021/j100484a019https://doi.org/10.1021/j100484a019research-articleACS PublicationsRequest reuse permissionsArticle Views1384Altmetric-Citations250LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts