gebhart/patrepeval huggingface dataset:
Circulating microRNAs in follicular fluid, powerful tools to explore in vitro fertilization process (2016)

Circulating or "extracellular" microRNAs (miRNAs) detected in biological fluids, could be used as potential diagnostic and prognostic biomarkers of several disease, such as cancer, gynecological and pregnancy disorders. However, their contributions in female infertility and in vitro fertilization (IVF) remain unknown. This study investigated the expression profiles of five circulating miRNAs (let-7b, miR-29a, miR-30a, miR-140 and miR-320a) in human follicular fluid from 91 women with normal ovarian reserve and 30 with polycystic ovary syndrome (PCOS) and their ability to predict IVF outcomes. The combination of FF miR-30a, miR-140 and let-7b expression levels discriminated between PCOS and normal ovarian reserve with a specificity of 83.8% and a sensitivity of 70% (area under the ROC curve, AUC = 0.83 [0.73-0.92]; p < 0.0001). FF samples related to low number of mature oocytes (≤2) contained significant less miR-320a levels than those related to a number of mature oocytes >2 (p = 0.04). Moreover, FF let-7b predicted the development of expanded blastocysts with 70% sensitivity and 64.3% specificity (AUC = 0.67 [0.54-0.79]; p = 0.02) and FF miR-29a potential to predict clinical pregnancy outcome reached 0.68 [0.55-0.79] with a sensitivity of 83.3% and a specificity of 53.5% (p = 0.01). Therefore, these miRNAs could provide new helpful biomarkers to facilitate personalized medical care during IVF.
Accurate free-form surface actuation using a non-pre-stretched silicone dielectric polymer actuator (2011)

Dielectric polymer actuators promise to revolutionize user interfaces by enabling surface actuators that can change surface shape and give tactile feedback from a thin layer. We have realized a programmable surface actuator, based on non-pre-stretched silicone, which is capable of realizing large freeform surface deformations from relatively thin layers, while maintaining very good control over the shape of the actuated surface. Moreover, the actuator setup allows the use of a thin, stiff top layer, which addresses friction and stickiness problems commonly associated with using soft elastomers in tactile displays. Out-of-plane deformations exceeding 300 μm are possible, facilitating 'tactile exploration' of the actuated shapes.
Neuroprotective effect of interleukin‐6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome (2001)

Ciliary neurotrophic factor prevents behavioural deficits and striatal degeneration in rat and primate models of Huntington's disease. Interleukin-6, another member of the cytokine family, and the chimeric molecule (IL6/IL6R) in which interleukin-6 and its soluble receptor are fused, have been shown to exert trophic action on various neuronal populations in the central nervous system. Therefore, we investigated the neuroprotective effect of these two molecules in the quinolinic acid model of Huntington's disease. LacZ-, interleukin-6- and IL6/IL6R-expressing lentiviral vectors were stereotaxically injected into the striatum of Wistar rats. Three weeks later the animals were lesioned through the intrastriatal injection of 180 nmol of quinolinic acid. The extent of the striatal damage was significantly diminished in the rats that had been treated with interleukin-6 or IL6/IL6R. The neuroprotective effect was, however, more pronounced with the IL6/IL6R chimera than with interleukin-6 as indicated by the volume of the lesions (38.6 +/- 10% in the IL6/IL6R group, 63.3 +/- 3.6% in the IL-6 group and 84.3 +/-2.9% in the control group). Quantitative analysis of striatal interneurons further demonstrated that the IL6/IL6R chimera is more neuroprotective than IL-6 on ChAT- and NADPH-d-immunoreactive neurons. These results suggest that the IL6/IL6R chimera is a potential treatment for Huntington's disease.
Carrier Injection Characteristics of Organic Electroluminescent Devices (1994)

The junction characteristics of metal/organic (M/Org) and organic/organic (Org/Org) interfaces, composing an organic electroluminescent (EL) device, M/Alq3/Diamine/ITO, were studied by measuring the displacement current characteristics of M/Org/Org/ SiO 2 /Si structures. The M/Alq3 junction was found to be both electron and hole injective, depending on the metal electrode. As for the Alq3/Diamine interface, it was found that two band offsets (Φ VB and Φ CB ) existed for respective valence and conduction bands. Φ VB was not very large, and holes in Diamine were able to pass through into the adjacent Alq3 layer by applying a forward-bias, but Φ CB was so large that the electrons in Alq3 were blocked. Based on the standpoint that characteristics of the organic thin-film devices are governed by those junctions, we discussed carrier-injection mechanism, and explain the efficient EL emission.
Experimental Verification of Wandering Spur Suppression Technique in a 4.9 GHz Fractional-N Frequency Synthesizer (2021)

Apart from the well-known nonlinearity-induced fixed spurs, a DDSM divider-based fractional- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$N$</tex> frequency synthesizer can manifest spurs with time-varying frequency offsets from the carrier; these are called wandering spurs. This paper presents experimental results for a 4.9 GHz CP-PLL fractional- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$N$</tex> PLL featuring a modified MASH-based divider controller that implements wandering spur suppression. The synthesizer achieves a 20 dB reduction in the spectral envelope of the short-term output phase noise spectrum when compared to the standard MASH DDSM divider controller.
Carrier Ethernet System Supporting Flexible Media Management (2006)

The paper relates to a Carrier Ethernet system supporting multiple media, a medium managing method therefore, and a switching system using the same. More particularly, this relates to an Ethernet port supporting multiple physical media that can use and manage multiple transmission media by freely selecting and exchanging the transmission media with another one in a switching system using ports, such as switches and routers, a medium managing method therefore, and a switching system using the Ethernet port. In other words, a system user forms two different types of physical media, which are copper cable and optical cable, in the switching system that can include multiple Ethernet ports, upon a request from the user, and exchanges and substitutes the physical media flexibly with another media in the operation of the switching system. This method offers an advantage to network operator and systems developer and also reduces system price.
The Prolactin Receptor Gene is Associated with Increased Litter Size In Pigs (1998)

The prolactin receptor gene was investigated as a candidate gene for reproduction traits in five PIC lines consisting of Large White (2), Landrace, Duroc, and Large White/Meishan origin. Least squares means for total number born (TNB) and number born alive (NBA) were calculated for each genotype in addition to an analysis of additive and dominance effects by line. The PRLR gene was significantly associated with TNB and/or NBA in three of the lines tested. The effect was greater than one pig for NBA in one line, although the effect clearly varied depending on the background genetics of the line. Additional data is needed to confirm the significant effects seen in these three lines. However, the effects observed to date suggest that this gene test has the potential to be a powerful tool when used in conjunction with traditional selection methods for some lines.
A Reconfigurable Microstrip Leaky-Wave Antenna With a Broadly Steerable Beam (2011)

A half-width microstrip leaky-wave antenna with an electronically steerable main beam is introduced. Lumped capacitors are connected between the free edge of the antenna and the ground plane through computer controlled switches, allowing the phase constant of the propagating wave to be varied. Consequently, the main beam of the antenna can be directed along any chosen direction in the longitudinal plane, at any frequency within the operating band of the antenna. By recalling stored switch combinations, the antenna may be steered at a certain frequency, or the antenna may be frequency-scanned while maintaining the beam at a fixed angle. The antenna may also be operated in a dynamic mode using a feedback system, where appropriate switch configurations are determined in real time using an efficient search algorithm. As a proof of concept, simulations are used to determine switch states to allow beam steering through nearly a full 180 degree scan range and also to keep the main beam at a fixed angle across a broad frequency spectrum.
Towards generation of mJ-level ultrashort THz pulses by optical rectification (2011)

Optical rectification of ultrashort laser pulses in LiNbO3 by tilted-pulse-front excitation is a powerful way to generate near single-cycle terahertz (THz) pulses. Calculations were carried out to optimize the output THz peak electric field strength. The results predict peak electric field strengths on the MV/cm level in the 0.3-1.5 THz frequency range by using optimal pump pulse duration of about 500 fs, optimal crystal length, and cryogenic temperatures for reducing THz absorption in LiNbO3. The THz electric field strength can be increased further to tens of MV/cm by focusing. Using optimal conditions together with the contact grating technique THz pulses with 100 MV/cm focused electric field strength and energies on the tens-of-mJ scale are feasible.
Cross-plane chroma enhancement for SHVC Inter-Layer Prediction (2013)

This paper proposes a cross-plane chroma enhancement (CPCE) scheme to enhance the chroma planes of the inter layer reference (ILR) pictures for the Scalable extensions of HEVC (SHVC), the on-going scalable video coding project in JCT-VC. The CPCE scheme restores the blurred edges and textures in the chroma planes using the corresponding information from the luma plane. Experimental results under the SHVC common test conditions show that the average BD-rate reductions for the Cb and Cr chroma planes are as much as -7.5% and -8.5%, respectively, when compared with SHM-1.0.
Localization of Transcranial Targets for Photoacoustic-Guided Endonasal Surgeries (2015)

Neurosurgeries to remove pituitary tumors using the endonasal, transsphenoidal approach often incur the risk of patient death caused by injury to the carotid arteries hidden by surrounding sphenoid bone. To avoid this risk, we propose intraoperative photoacoustic vessel visualization with an optical fiber attached to the surgical tool and an external ultrasound transducer placed on the temple. Vessel detection accuracy is limited by acoustic propagation properties, which were investigated with k-Wave simulations. In a two-layer model of temporal bone (3200 m/s sound speed, 1-4 mm thickness) and surrounding tissues, the localization error was ≤2 mm in the tranducer's axial dimension, while temporal bone curvature further degraded target localization. Phantom experiments revealed that multiple image targets (e.g. sphenoid bone and vessels) can be visualized, particularly with coherence-based beamforming, to determine tool-to-vessel proximity despite expected localization errors. In addition, the potential flexibility of the fiber position relative to the transducer and vessel was elucidated.
Germline Variation in Cancer-Susceptibility Genes in a Healthy, Ancestrally Diverse Cohort: Implications for Individual Genome Sequencing (2014)

Technological advances coupled with decreasing costs are bringing whole genome and whole exome sequencing closer to routine clinical use. One of the hurdles to clinical implementation is the high number of variants of unknown significance. For cancer-susceptibility genes, the difficulty in interpreting the clinical relevance of the genomic variants is compounded by the fact that most of what is known about these variants comes from the study of highly selected populations, such as cancer patients or individuals with a family history of cancer. The genetic variation in known cancer-susceptibility genes in the general population has not been well characterized to date. To address this gap, we profiled the nonsynonymous genomic variation in 158 genes causally implicated in carcinogenesis using high-quality whole genome sequences from an ancestrally diverse cohort of 681 healthy individuals. We found that all individuals carry multiple variants that may impact cancer susceptibility, with an average of 68 variants per individual. Of the 2,688 allelic variants identified within the cohort, most are very rare, with 75% found in only 1 or 2 individuals in our population. Allele frequencies vary between ancestral groups, and there are 21 variants for which the minor allele in one population is the major allele in another. Detailed analysis of a selected subset of 5 clinically important cancer genes, BRCA1, BRCA2, KRAS, TP53, and PTEN, highlights differences between germline variants and reported somatic mutations. The dataset can serve a resource of genetic variation in cancer-susceptibility genes in 6 ancestry groups, an important foundation for the interpretation of cancer risk from personal genome sequences.
<title>Combining fast search and learning for fast similarity search</title> (1999)

In this paper,we propose a new scalable simultaneous learning and indexing technique for efficient content-based retrieval of images that can be described by high- dimensional feature vectors. This scheme combines the elements of an efficient nearest neighbor search algorithm, and a relevance feedback learning algorithm which refines the raw feature space to the specific subjective needs of each new application, around a commonly shared compact indexing structure based on recursive clustering. Consequently, much better time efficiency and scalability can be achieved as compared to those techniques that do not make provisions for efficient indexing or fast learning steps. After an overview of the current related literature, and a presentation of our objectives and foundations, we describe in detail the three aspects of our technique: learning, indexing and similarity search. We conclude with an analysis of the objectives met, and an outline of the current work and considered future enhancements and variations on this technique.
The Electrochemical Detection of Arsenic(III) at a Silver Electrode (2005)

Abstract A study of three electrode substrates namely gold, platinum and silver, for arsenic detection via anodic stripping voltammetry is reported. Hitherto it has been accepted that gold is the most suitable metallic surface for use in this context, as suggested by Forsberg and co‐workers (Forsberg, G.; O'Laughlin, J. W.; Megargle, R. G. Anal. Chem. 1975, 47, 1586.). We revisit these experiments and find that by switching from hydrochloric acid to nitric acid the oxidation of silver that had previously masked the arsenic stripping signal at this surface is shifted considerably enough to allow a clear, analytically reliable As(III) stripping signal to be detected. In contrast to silver and gold platinum is found to have poor performance as an electrode substrate for arsenic detection. Using ASV a LOD of 6.3×10 −7 M is found for As(III) detection at a silver electrode, similar to that which we have previously reported at a gold electrode (A. O. Simm, C. E. Banks and R. G. Compton. Electroanalysis , 2005, 17, 335.) The use of ultrasound was then investigated to further reduce the LOD, which was found to be 1.4×10 −8 M. Apart from reduced cost of silver it also has an added advantage over gold in that it has a higher hydrogen reduction overvoltage enabling a 100 mV more negative deposition potential to be used before the onset of hydrogen evolution when compared to a gold electrode.
Photoconductivity in Tl<sub>6</sub>SI<sub>4</sub>: A Novel Semiconductor for Hard Radiation Detection (2013)

The chemical concept of lattice hybridization was applied to identify new chalcohalide compounds as candidates for X-ray and γ-ray detection. Per this approach, compound semiconductor materials with high density and wide band gaps can be produced that can absorb and detect hard radiation. Here, we show that the mixed chalcogenide–halide compound Tl6SI4 is a congruently melting, mechanically robust chalcohalide material with strong photoconductivity response and an impressive room-temperature figure of merit. Tl6SI4 crystallizes in the tetragonal P4/mnc space group, with a = 9.1758(13) Å, c = 9.5879(19) Å, V = 807.3(2) Å3, and a calculated density of 7.265 g·cm–3. The new material requires a more simplified crystal growth compared to the leading system Cd0.9Zn0.1Te, which is the benchmark room-temperature hard radiation detector material. We successfully synthesized Tl6SI4 crystals to produce detector-grade wafers with high resistivity values (∼1010 Ω·cm) and high-resolution detection of X-ray spectra from an Ag (22 keV) source.
Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90 (2016)

Two new scalarane sesterterpenoids, 12β-(3'β-hydroxybutanoyloxy)-20,24-dimethyl-24-oxo-scalara-16-en-25-al (1) and 12β-(3'β-hydroxypentanoyloxy)-20,24-dimethyl-24-oxo-scalara-16-en-25-al (2), along with one known tetraprenyltoluquinol-related metabolite (3), were isolated from the sponge Carteriospongia sp. In leukemia Molt 4 cells, 1 at 0.0625 μg/mL (125 nM) triggered mitochondrial membrane potential (MMP) disruption and apoptosis showing more potent effect than 2 and 3. The isolates inhibited topoisomerase IIα expression. The apoptotic-inducing effect of 3 was supported by the in vivo experiment through suppressing the volume of xenograft tumor growth (47.58%) compared with the control. Compound 1 apoptotic mechanism of action in Molt 4 cells was further elucidated through inducing ROS generation, calcium release and ER stress. Using the molecular docking analysis, 1 exhibited more binding affinity to N-terminal ATP-binding pocket of Hsp90 protein than 17-AAG, a standard Hsp90 inhibitor. The expression of Hsp90 client proteins, Akt, p70<sup>S6k</sup>, NFκB, Raf-1, p-GSK3β, and XIAP, MDM 2 and Rb2, and CDK4 and Cyclin D3, HIF 1 and HSF1 were suppressed by the use of 1. However, the expression of Hsp70, acetylated tubulin, and activated caspase 3 were induced after 1 treatment. Our results suggested that the proapoptotic effect of the isolates is mediated through the inhibition of Hsp90 and topoisomerase activities.
Evidence for Prostate Cancer-Associated Diagnostic Marker-1 (2004)

Taken together, the data suggest that PCADM-1 is a specific marker for human prostate cancer.
Trequinsin, a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones (1984)

Series of 3-substituted-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido [6,1-a]isoquinoline-2,4-diones and 2-substituted-9,10-dimethoxy-6,7-dihydro-4H-pyrimido [6,1-a]isoquinolin-4-ones were synthesized and tested for blood pressure lowering properties in anesthetized normotensive cats and conscious spontaneously hypertensive rats. Several compounds in the 2-(arylamino)-9,10-dimethoxy-6,7-dihydro-4H-pyrimido [6,1-a]isoquinolin-4-one series display a high order of activity. The most active compounds are the alkyl derivatives of the 2-mesitylamino/2-mesitylimino tautomeric forms. The 2-(mesitylimino)-3-methyl analogue trequinsin is a potent antihypertensive agent and displays a hemodynamic profile characteristic of an arteriolar dilator. It is also a potent inhibitor of both cAMP phosphodiesterase and platelet aggregation.
A method for stabilizing RNA for transfection that allows control of expression duration (2010)

RNA transfection methods have not proven to be as popular as DNA methods due to the highly transient nature of the RNA inside the cell. However, there are many advantages in using RNA for gene over-expression, such as the rapidity of expression, the ability to express in all cell types without the need for cell-type-specific promoters, and the ability to analyze the effects of gene over-expression in a transient manner. Therefore, we have developed a method (StabiLizingUtr: SLU) to stabilize the RNA for varying durations, using specific sequences from the 3'UTR of the Venezuelan equine encephalitis virus (VEEV). We have designed a plasmid for cloning genes upstream from repeated stabilizing sequences to generate mRNA with one or more VEEV-stabilizing sequence motifs. We demonstrate this method in several cell and tissue types, including the mammalian cochlea, a tissue that has been difficult to transfect with other methods.
Heart Protection Using a New Approach - Antisense to Angiotensin Converting Enzyme Mrna (2000)

P200 Introduction. Angiotensin converting enzyme (ACE), plays a major role in many cardiovascular pathophysiological conditions, such as hypertension, heart failure and myocardial ischemia. Currently used ACE inhibitors have some adverse effects and non-compliance problem. Therefore, our lab has been developing an antisense approach to inhibit the renin-angiotensin system at the gene expression level. The present study had three aims: 1. Design antisense oligodeoxynucleotide (AS-ODN) directed at ACE mRNA 2. Check tissue distribution of AS after iv injection 3. Test AS for heart protection in ischemia- reperfusion injury Methods. Epifluorescent and confocal laser-scanning microscopy, immunohistochemistry, Western blotting. Animals : mice, males, 20 g and Sprague-Dawley rats, males, 200-250 g. AS 5’ -ATTTCGTGGTGGG-3’ , inverted control (INV) 5’ -GGGTGGTGCTTTA-3’, phosphorothioates mixed with liposomes and injected iv 0.04 mg/mouse and 0.2 mg/rat. Captopril dose was 5 mg/kg. Isolated perfused heart function recordings : coronary perfusion pressure (CPP), left ventricular end-diastolic (LVEDP) and systolic pressures (LVSP). Results. Based on the rat ACE cDNA sequence, the AS was designed as 13-mer directed to the second zinc-binding domain (2998-3010 bp). Tissue distribution of phosphorothioated, fluorescein isothiocyanate (FITC)-labeled AS, 4h after iv injection, showed its presence in the lung, spleen, liver and heart, but absence in the brain. Immunostaining of the parallel heart slices with anti sarcomeric alpha-actinin antibody indicated AS localization within cardiomyocytes. ACE AS injected iv to the rats 24 h before excising the heart, which was then subjected to 25 min ischemia and 30 min reperfusion, preserved heart function. Increase in CPP and LVEDP during reperfusion was attenuated by AS as compared to INV or saline treatment (n=8 in each group, p<0.05). Moreover, ACE protein was not upregulated, as it was in the captopril-treated group. Conclusion. ACE AS is taken up by the heart tissue and provides cardioprotection by effectively preventing myocardial dysfunction caused by ischemia-reperfusion injury.