gebhart/patrepeval huggingface dataset:
The newly diagnosed vestibular schwannoma: radiosurgery, resection, or observation? (2012)

Based on published data on both volume and hearing preservation for both strategies, the authors devised a management recommendation for patients with small vestibular schwannomas. When resection is not chosen by the patient, the authors believe that early SRS intervention, in contrast to observation, results in long-term tumor control and improved rates of hearing preservation.
High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion (2012)

Vimentin is an intermediate filament protein, with a key role in the epithelial to mesenchymal transition as well as cell invasion, and it is often upregulated during cancer progression. However, relatively little is known about its regulation in cancer cells. Here, we performed an RNA interference screen followed by protein lysate microarray analysis in bone metastatic MDA-MB-231(SA) breast cancer cells to identify novel regulators of vimentin expression. Out of the 596 genes investigated, three novel vimentin regulators EPHB4, WIPF2 and MTHFD2 were identified. The reduced vimentin expression in response to EPHB4, WIPF2 and MTHFD2 silencing was observed at mRNA and protein levels. Bioinformatic analysis of gene expression data across cancers indicated overexpression of EPHB4 and MTHFD2 in breast cancer and high expression associated with poor clinical characteristics. Analysis of 96 cDNA samples derived from both normal and malignant human tissues suggested putative association with metastatic disease. MTHFD2 knockdown resulted in impaired cell migration and invasion into extracellular matrix as well as decreased the fraction of cells with a high CD44 expression, a marker of cancer stem cells. Furthermore, MTHFD2 expression was induced in response to TGF-β stimulation in breast cancer cells. Our results show that MTHFD2 is overexpressed in breast cancer, associates with poor clinical characteristics and promotes cellular features connected with metastatic disease, thus implicating MTHFD2 as a potential drug target to block breast cancer cell migration and invasion.
Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases (2017)

Reconstruction of mediastinal vessels for invasive thymoma is a feasible technology method. Radical resection of the tumor with involved neighboring structures is the key to prolong overall survival for patients suffered from invasive thymoma.
Four-Batch Fuel Management with Plutonium Recycling (1989)

Pressurized water reactor four-batch fuel management represents, in the present context, an economic optimum for the French standardized series of reactors. Plutonium recycling on an industrial scale has already started in France; therefore, it is essential to ascertain its compatibility with four-batch refueling requirements.In the survey considered, it is shown that a core refueled annually with 28 UO2 assemblies, having a 3.7% 235 U content and 12 mixed-oxide assemblies containing 6.5% plutonium, entirely satisfies safety criteria under normal operating conditions. A supplementary survey will be performed to assess its behavior under such accident conditions as steam line break and rod ejection.
Perilipin Overexpression in White Adipose Tissue Induces a Brown Fat-Like Phenotype (2010)

These findings demonstrate that overexpression of PeriA in white adipocytes reduces lipid droplet size by decreasing FSP27 expression and thereby inducing a brown adipose tissue-like phenotype. Our data suggest that modulation of lipid droplet proteins in white adipocytes is a potential therapeutic strategy for the treatment of obesity and its related disorders.
Design and control of an active reset circuit for pulse transformers (2009)

In pulse modulators applying pulse transformers reset circuits are used to achieve optimal utilization of the core material, which results in lower costs, downsized pulse transformer/system volume and therefore in an improved pulse behavior due to the smaller parasitics. Because of its simplicity the most common method to reset the core is a DC reset circuit, where a DC current is used to premagnetize the core. However, the DC reset circuit - even with an optimal design-leads to significant losses in the freewheeling path. By applying an active reset method the losses due to the passive reset circuit can be reduced significantly. So far, only the theoretical behavior of the active reset circuit has been examined. Therefore, the detailed design and measurement results are presented in this paper. Furthermore, a new control method for achieving symmetrical flux swings in the core is presented.
Analysis and Design of UWB Modified Two-Sections Wilkinson Power Splitter (2015)

In this paper, the analysis and design of a compact Ultra-Wideband (UWB) Wilkinson Power Splitter (WPS) is presented. The proposed splitter consists of two sections Wilkinson power splitter of equal characteristic impedances and unequal electrical lengths with a single stub on each section. The proposed power splitter examined analytically using the “Even Odd Mode” analysis method and the ABCD matrix. The simulation is done using Agilent ADS circuit and EM simulator. The proposed structure achieves an input return loss, S11 better than 12.2 dB, an output return loss, S22 and S33 better than 19.59 dB, output ports isolation, S23 and S32 better than 12.75 dB and insertion loss, S21 and S31 from 3.15 to 3.41dB through the whole UWB range from 3.1 GHz to 10.6 GHz. Furthermore, the power splitter has a compact size of 18.38 * 10.25 mm2 compared to other similar networks.
Mid-infrared difference-frequency generation of ultrashort pulses tunable between 32 and 48 μm from a compact fiber source (2007)

We report single-pass difference-frequency generation of mid-infrared femtosecond pulses tunable in the 3.2-4.8 microm range from a two-branch mode-locked erbium-doped fiber source. Average power levels of up to 1.1 mW at a repetition rate of 82 MHz are obtained in the mid infrared. This is achieved via nonlinear mixing of 170 mW, 65 fs pump pulses at a fixed wavelength of 1.58 microm, with 11.5 mW, 40 fs pulses tunable in the near-infrared range between 1.05 and 1.18 microm. These values indicate that the tunable near-infrared input component is downconverted with a quantum efficiency that exceeds 30%.
Localization of components of the chemotaxis machinery of <i>Escherichia coli</i> using fluorescent protein fusions (2000)

We prepared fusions of yellow fluorescent protein [the YFP variant of green fluorescent protein (GFP)] with the cytoplasmic chemotaxis proteins CheY, CheZ and CheA and the flagellar motor protein FliM, and studied their localization in wild‐type and mutant cells of Escherichia coli . All but the CheA fusions were functional. The cytoplasmic proteins CheY, CheZ and CheA tended to cluster at the cell poles in a manner similar to that observed earlier for methyl‐accepting chemotaxis proteins (MCPs), but only if MCPs were present. Co‐localization of CheY and CheZ with MCPs was CheA dependent, and co‐localization of CheA with MCPs was CheW dependent, as expected. Co‐localization with MCPs was confirmed by immunofluorescence using an anti‐MCP primary antibody. The motor protein FliM appeared as discrete spots on the sides of the cell. These were seen in wild‐type cells and in a fliN mutant, but not in flhC or fliG mutants. Co‐localization with flagellar structures was confirmed by immunofluorescence using an antihook primary antibody. Surprisingly, we did not observe co‐localization of CheY with motors, even under conditions in which cells tumbled.
Freeze-etching in Scanning Electron Microscopy (1974)

Freeze-etching in Scanning Electron Microscopy Get access Tokio NEI, Tokio NEI *The Institute of Low Temperature Science, Hokkaida UniversitySapporo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Haruo YOTSUMOTO, Haruo YOTSUMOTO Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoiti HASEGAWA, Yoiti HASEGAWA Search for other works by this author on: Oxford Academic PubMed Google Scholar Masao HASEGAWA Masao HASEGAWA Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Electron Microscopy, Volume 23, Issue 2, 1974, Pages 137–138, https://doi.org/10.1093/oxfordjournals.jmicro.a049916 Published: 01 January 1974 Article history Published: 01 January 1974 Received: 30 April 1974
Spectral broadening in anatase titanium dioxide waveguides at telecommunication and near-visible wavelengths (2013)

We observe spectral broadening of femtosecond pulses in single-mode anatase-titanium dioxide (TiO(2)) waveguides at telecommunication and near-visible wavelengths (1565 and 794 nm). By fitting our data to nonlinear pulse propagation simulations, we quantify nonlinear optical parameters around 1565 nm. Our fitting yields a nonlinear refractive index of 0.16 × 10(-18) m(2)/W, no two-photon absorption, and stimulated Raman scattering from the 144 cm(-1) Raman line of anatase with a gain coefficient of 6.6 × 10(-12) m/W. Additionally, we report on asymmetric spectral broadening around 794 nm. The wide wavelength applicability and negligible two-photon absorption of TiO(2) make it a promising material for integrated photonics.
Modelling Taxi Drivers’ Behaviour for the Next Destination Prediction (2019)

In this paper, we study how to model taxi drivers' behavior and geographical information for an interesting and challenging task: the next destination prediction in a taxi journey. Predicting the next location is a well-studied problem in human mobility, which finds several applications in real-world scenarios, from optimizing the efficiency of electronic dispatching systems to predicting and reducing the traffic jam. This task is normally modeled as a multiclass classification problem, where the goal is to select, among a set of already known locations, the next taxi destination. We present a Recurrent Neural Network (RNN) approach that models the taxi drivers' behavior and encodes the semantics of visited locations by using geographical information from Location-Based Social Networks (LBSNs). In particular, the RNNs are trained to predict the exact coordinates of the next destination, overcoming the problem of producing, in output, a limited set of locations, seen during the training phase. The proposed approach was tested on the ECML/PKDD Discovery Challenge 2015 dataset-based on the city of Porto-, obtaining better results with respect to the competition winner, whilst using less information, and on Manhattan and San Francisco datasets.
Functional analysis of antibacterial activity of <i>Bacillus amyloliquefaciens</i> phage endolysin against Gram‐negative bacteria (2001)

To analyze the antibacterial activity of Bacillus amyloliquefaciens phage endolysin, nine deletion derivatives of the endolysin were constructed. Each deletion mutant was overexpressed, purified and characterized. The catalytic domain was located on the N-terminal region and the C-terminus had an affinity with the bacterial envelope. The enzymatic activity remained in spite of the deletion of the C-terminal 116-amino acid region; however, the antibacterial activity was lost. These results indicate that antibacterial action requires both the C-terminal cell-binding and the N-terminal enzymatic activities.
What metaphor identification systems can tell us about metaphor-in-language (2013)

This paper evaluates four metaphor identification systems on the 200,000 word VU Amsterdam Metaphor Corpus, comparing results by genre and by sub-class of metaphor. The paper then compares the rate of agreement between the systems for each genre and sub-class. Each of the identification systems is based, explicitly or implicitly, on a theory of metaphor which hypothesizes that certain properties are essential to metaphor-inlanguage. The goal of this paper is to see what the success or failure of these systems can tell us about the essential properties of metaphorin-language. The success of the identification systems varies significantly across genres and sub-classes of metaphor. At the same time, the different systems achieve similar success rates on each even though they show low agreement among themselves. This is taken to be evidence that there are several sub-types of metaphor-in-language and that the ideal metaphor identification system will first define these sub-types and then model the linguistic properties which can distinguish these sub-types from one another and from nonmetaphors.
Evaluation of dextromethorphan with select antidepressant therapy for the treatment of depression in the acute care psychiatric setting (2019)

Dextromethorphan was not associated with a rapid antidepressant effect. The commonly used dose of 30 mg daily may have been too low to have an effect; additionally, the most frequently utilized select antidepressant, bupropion, has moderately less CYP2D6 inhibition than fluoxetine and paroxetine.
Charge-pump based switched-capacitor gain stage (2012)

A low-power switched-capacitor (SC) gain stage based on a capacitive charge-pump (CP) is proposed. It is shown that the CP gain stage achieves the same input-referred thermal noise as a conventional SC gain circuit, while consuming significantly lower power. The effect of parasitic capacitances on the CP gain circuit is discussed. Simulation results confirming the improved power/performance trade-off of the CP gain stage over the conventional approach are provided.
Enzymatic properties of vesicle‐reconstituted human cytochrome P450SCC (CYP11A1) (1999)

The recently reported heterologous expression and purification of both human cytochrome P450SCC and adrenodoxin [Woods, S.T., Sadleir, J., Downs, T., Triantopoulos, T., Haedlam, M.J. & Tuckey, R.C. (1998) Arch. Biochem. Biophys. 353, 109-115] has enabled us to perform studies with the membrane-reconstituted human enzymes to better understand the side-chain cleavage reaction in humans. Human P450SCC was successfully reconstituted into dioleoylphosphatidylcholine vesicles with and without cardiolipin and its enzymatic properties characterized in the membrane-bound state. Enhancement of the P450SCC activity and significant activation by cardiolipin were observed when human adrenodoxin instead of bovine adrenodoxin was used as electron donor. In the absence of cardiolipin, Km for cholesterol was decreased twice in the case of human adrenodoxin indicating enhanced cholesterol binding. On the other hand, in the presence of cardiolipin in the membrane both Km and V for cholesterol were decreased with human adrenodoxin as electron donor. Kinetic analysis of the interaction between human P450SCC and its redox partners provided evidence for enhanced binding of the human electron donor to human P450SCC indicated by both an increased V and decreased Kd for human adrenodoxin compared with the values with bovine adrenodoxin. Because no similar effects were observed in Tween 20 micelles, these results suggest that the phospholipid membrane may play an important role in the interaction of human adrenodoxin with human P450SCC.
Total synthesis and absolute configuration of the antibiotic oligopeptide (4S)-(+)-anthelvencin A and its 4R-(-) enantiomer (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis and absolute configuration of the antibiotic oligopeptide (4S)-(+)-anthelvencin A and its 4R-(-) enantiomerMoses Lee, Diane M. Coulter, and J. William LownCite this: J. Org. Chem. 1988, 53, 9, 1855–1859Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/jo00244a003https://doi.org/10.1021/jo00244a003research-articleACS PublicationsRequest reuse permissionsArticle Views476Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization and <i>de novo</i> sequencing of snow crab tropomyosin enzymatic peptides by both electrospary ionization and matrix‐assisted laser desorption ionization QqToF tandem mass spectrometry (2010)

The protein tropomyosin (TM) is a known major allergen present in shellfish causing frequent food allergies. TM is also an occupational allergen generated in the working environment of snow crab (Chionoecetes opilio) processing plants. The TM protein was purified from both claw and leg meats of snow crab and analyzed by electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) using hybrid quadruple time-of-flight tandem mass spectrometry (QqToF-MS). The native polypeptide molecular weight of TM was determined to be 32,733 Da. The protein was further characterized using the 'bottom-up' MS approach. A peptide mass fingerprinting was obtained by two different enzymatic digestions and de novo sequencing of the most abundant peptides performed. Any post-translational modifications were identified by searching their calculated and predicted molecular weights in precursor ion spectra. The immunological reactivity of snow crab extract was evaluated using specific antibodies and allergenic reactivity assessed with serum of allergic patients. Subsequently, a signature peptide for TM was identified and evaluated in terms of identity and homology using the basic local alignment search tool (BLAST). The identification of a signature peptide for the allergen TM using MALDI-QqToF-MS will be critical for the sensitive and specific quantification of this highly allergenic protein in the work place.
Working Models Of Specific Recognition In Plant-Microbe Interactions (1990)

Beneficial microbes in the microbiome of plant roots improve plant health. Induced systemic resistance (ISR) emerged as an important mechanism by which selected plant growth–promoting bacteria and fungi in the rhizosphere prime the whole plant body for ...Read More
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics (2018)

Slingshot is a uniquely robust and flexible tool which combines the highly stable techniques necessary for noisy single-cell data with the ability to identify multiple trajectories. Accurate lineage inference is a critical step in the identification of dynamic temporal gene expression.
CHROME REDUCTION AND HEAVY METALS REMOVAL FROM WASTEWATER - A POLLUTION PREVENTION APPROACH (2001)

A wastewater treatment and recycling project was developed for a metal cleaning facility in Lawrence Berkeley National Laboratory (LBNL). It was also an effort to meet the water conservation and pollution prevention goals of LBNL. This project included several tasks: (i) evaluation of alternative wastewater treatment methods, and (ii) installation of water saving and recycling processes. Heavy metals precipitation methods and various chromium reduction methods were tested for wastewater samples. Wastewater samples containing chrome was tested with the following methods: (1) sodium metabisulfite, (2) ferrous sulfate, and (3) dimethyl dithio carbamate, ferrous sulfate, and alum. It was found that (a) the first three treatment methods are all effective for chromium reduction or absorption, (b) the fourth method is not as effective for chromium reduction as the other three, (c) the efficiency of heavy metals precipitation process was influenced by the method of chromium reduction used prior to precipitation , and (d) in order to effectively precipitate heavy metals out of wastewater sample, coagulants (or coprecipitants) and polymer must be used. It was also found that by using a proper combination of chromium reduction and precipitation methods, the treated wastewater sample can meet the discharge limits. In the water saving and recycling study, a spray rinse system and two wastewater closed-loop recycling systems (reverse osmosis and ion exchange) were selected and installed for this facility. With the spray rinse system, the rinse water usage was reduced by at least 40%. With the closed-loop systems, another 50% of the wastewater (7.5 million liters/year) was recycled.
[Treatment of mild and moderate hypertension with fosinopril. Comparison of adverse effects with other antihypertensive agents]. (1994)

Fosinopril has demonstrated therapeutic efficacy and less adverse reactions compared to antihypertensives used previously as monotherapy.
Probiotic yeasts: Anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice (2010)

A careful selection of strains is required among the biodiversity of yeasts for specific clinical studies, including applications in inflammatory bowel disease and other therapeutic uses.
Air haptics (2015)

"Air Haptics" is a visuo-haptic Augmented Reality (AR) system which gives us a sense of interacting with AR objects and characters like pinching and pulling, without any haptic devices, only using an effect of visuo-haptic interaction.
Pembrolizumab plus axitinib: a new treatment option for patients with metastatic renal cell carcinoma (2019)

The treatment scenario for patients with metastatic renal cell carcinoma (mRCC) is witnessing its third revolution: the first was the advent of anti-angiogenic targeted therapies, consisting in tyrosine-kinase inhibitors (TKIs) targeting vascular endothelial growth factor (VEGF); the second was the introduction of immunotherapy, consisting in immune checkpoint inhibitors (ICI), like anti-programmed death 1 (PD-1) receptor or anti-programmed death ligand 1 (PD-L1); the third and current revolution is the advent of ICI and TKIs combination.
MINTS: A general framework and tool for supporting test-suite minimization (2009)

Test-suite minimization techniques aim to eliminate redundant test cases from a test-suite based on some criteria, such as coverage or fault-detection capability. Most existing test-suite minimization techniques have two main limitations: they perform minimization based on a single criterion and produce suboptimal solutions. In this paper, we propose a test-suite minimization framework that overcomes these limitations by allowing testers to (1) easily encode a wide spectrum of test-suite minimization problems, (2) handle problems that involve any number of criteria, and (3) compute optimal solutions by leveraging modern integer linear programming solvers. We implemented our framework in a tool, called MINTS, that is freely-available and can be interfaced with a number of different state-of-the-art solvers. Our empirical evaluation shows that MINTS can be used to instantiate a number of different test-suite minimization problems and efficiently find an optimal solution for such problems using different solvers.
Mannose-Binding Lectin Variant Alleles and the Risk of Arterial Thrombosis in Systemic Lupus Erythematosus (2004)

Among patients with SLE, homozygosity for mannose-binding lectin variant alleles is associated with an increased risk of arterial thrombosis. The risk of venous thrombosis is not increased, indicating that mannose-binding lectin has a specific role in providing protection against arterial thrombosis.