gebhart/patrepeval huggingface dataset:
Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits. (1993)

Only serine phosphorylation of eukaryotic initiation factor-4E (eIF-4E) has been previously reported in intact cells. We found that treatment of HepG2 cells with okadaic acid resulted in as much as 20% of eukaryotic initiation factor (eIF)-4E phosphorylation occurring on threonine residues and that tryptic phosphopeptide maps showed several previously unrecognized phosphopeptides. Analysis of p220 from control and okadaic acid-treated cells demonstrated serine and threonine phosphorylation under both conditions. However, a unique pattern of phosphopeptides in okadaic acid-treated cells was observed. The most notable finding was that hyperphosphorylation of eIF-4E and p220 increased binding of p220 but not eIF-4E to the m7GTP cap structure. We suggest that phosphorylation of eIF-4E is more complicated than previously recognized and that hyperphosphorylation of eIF-4E and p220 recruits more p220 into the protein complex that associates with mRNA caps. A better understanding of these protein-protein and protein-mRNA interactions may aid the design of anti-sense directed chemistries that disrupt such interactions for a specific target mRNA (Baker, B.F., Miraglia, L., and Hagedorn, C. H. (1992) J. Biol. Chem. 267, 11495-11499).
Cardioselective beta-blockers for chronic obstructive pulmonary disease (2002)

The available evidence suggests that cardioselective beta-blockers, given to patients with COPD do not produce a significant short-term reduction in airway function or in the incidence of COPD exacerbations. However, the trials were small and of short duration. Given their demonstrated benefit in conditions such as heart failure, coronary artery disease and hypertension, cardioselective beta-blockers should be considered for patients with COPD, but administered with careful monitoring since data concerning long term administration and their effects during exacerbations are not available.
DaRoute: Inferring trajectories from zero-permission smartphone sensors (2021)

Nowadays, smartphones are equipped with a multitude of sensors, including GPS, that enables location-based services. However, leakage or misuse of user locations poses a severe privacy threat, motivating operating systems to usually restrict direct access to these resources for applications. Nevertheless, this work demonstrates how an adversary can deduce sensitive location information by inferring a vehicle’s trajectory through inbuilt motion sensors collectible by zero-permission mobile apps. Therefore, the presented attack incorporates data from the accelerometer, the gyroscope, and the magnetometer. We then extract so-called path events from raw data to eventually match them against reference data from OpenStreetMap. At the example of real-world data from three different cities, several drivers, and different smartphones, we show that our approach can infer traveled routes with high accuracy within minutes while robust to sensor errors. Our experiments show that even for areas as large as approximately 4500 $\mathrm{k}\mathrm{m}^{2}$, the accuracy of detecting the correct route is as high as 87.14%, significantly outperforming similar approaches from Narain et al. and Waltereit et al.
Photochemistry in the electronic ground state. I. Vapor-phase irradiation of organic compounds by continuous wave carbon dioxide gas laser (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry in the electronic ground state. I. Vapor-phase irradiation of organic compounds by continuous wave carbon dioxide gas laserAmnon Yogev, Ruth M. J. Loewenstein, and Dan AmarCite this: J. Am. Chem. Soc. 1972, 94, 4, 1091–1096Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://pubs.acs.org/doi/10.1021/ja00759a010https://doi.org/10.1021/ja00759a010research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Timing attacks on Web privacy (2000)

Article Timing attacks on Web privacy Share on Authors: Edward W. Felten Secure Internet Programming Laboratory, Department of Computer Science, Princeton University, Princeton, NJ Secure Internet Programming Laboratory, Department of Computer Science, Princeton University, Princeton, NJView Profile , Michael A. Schneider Secure Internet Programming Laboratory, Department of Computer Science, Princeton University, Princeton, NJ Secure Internet Programming Laboratory, Department of Computer Science, Princeton University, Princeton, NJView Profile Authors Info & Claims CCS '00: Proceedings of the 7th ACM conference on Computer and Communications SecurityNovember 2000 Pages 25–32https://doi.org/10.1145/352600.352606Online:01 November 2000Publication History 152citation1,885DownloadsMetricsTotal Citations152Total Downloads1,885Last 12 Months89Last 6 weeks12 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Maximizing heterozygosity in autopolyploids. (1980)

Polyploidy appears dependent on heterozygosity! The largest group of polyploids, the allopolyploids (disomic polyploids), have fixed heterozygosity in the two or more divergent genomes they possess (e.g., wheat, oats, cotton, tobacco, etc.). Hexaploid wheat, for example, although self-pollinated and basically homozygous at loci in each of its three genomes, has internal hybridity among loci with similar function in its three genomes. Disomic polyploids thus are able to capitalize on the merits of both the self- and cross-fertilizing systems (1).
Static Load Testing of Concrete Free Reticulated Micropiles System (2016)

Surefoot is a new steel micropile group footing system, light enough to be manually handled by a single operator and installed using very simple power tools. It does not require excavation, drilling or use of any concrete. Surefoot can be described as a “Braced Batter Micropile Group”. it is comprised of an adjustable steel pile cap with 3 to 16 “inclined micropiles”, depending on the nature and magnitude of loads and soil conditions. To evaluate the ultimate capacity of the new foundation system and assess the applicability of current pile design methods to this new system, a series of static pile load tests were performed. Testing regime covered a range of geometric configurations and embedment depths of the new footing system. All testing was conducted in an area with surface geology of quaternary basaltic clay deposits in Braybrook, Victoria. This paper presents results of site classification, in-situ strength tests, laboratory strength tests, along with the field static load tests on the new micropile footing system. The field test results were analysed using a range of methods to\nanticipate the failure load.
White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism (2013)

OBJECTIVE The authors sought to determine whether specific patterns of oculomotor functioning and visual orienting characterize 7-month-old infants who later meet criteria for an autism spectrum disorder (ASD) and to identify the neural correlates of these behaviors. METHOD Data were collected from 97 infants, of whom 16 were high-familial-risk infants later classified as having an ASD, 40 were high-familial-risk infants who did not later meet ASD criteria (high-risk negative), and 41 were low-risk infants. All infants underwent an eye-tracking task at a mean age of 7 months and a clinical assessment at a mean age of 25 months. Diffusion-weighted imaging data were acquired for 84 of the infants at 7 months. Primary outcome measures included average saccadic reaction time in a visually guided saccade procedure and radial diffusivity (an index of white matter organization) in fiber tracts that included corticospinal pathways and the splenium and genu of the corpus callosum. RESULTS Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants. Visual orienting latencies were uniquely associated with the microstructural organization of the splenium of the corpus callosum in low-risk infants, but this association was not apparent in infants later classified as having an ASD. CONCLUSIONS Flexibly and efficiently orienting to salient information in the environment is critical for subsequent cognitive and social-cognitive development. Atypical visual orienting may represent an early prodromal feature of an ASD, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.
DUMBONET: a multimedia communication system for collaborative emergency response operations in disaster-affected areas (2007)

This article describes an emergency communication network platform based on a hybrid combination of Mobile Ad Hoc Networking (MANET) and a satellite IP network operating with conventional terrestrial internet. It is designed for collaborative simultaneous emergency response operations deployed in a number of disaster-affected areas. The architecture of the network, called DUMBONET, and our emergency response applications are described. Experience from a real-life experimental test-bed is discussed. Our implementation involves multidisciplinary research areas such as MANET routing, peer-to-peer computing, sensor networks and face recognition. The article also identifies potential research challenges that we intend to investigate to further enhance the capabilities of our system.
Monoclonal Antibodies: Pragmatic Application of Immunology and Cell Biology2 (1986)

Monoclonal antibodies represent a natural extension of research efforts directed at understanding the structure and function of antibody molecules. In this paper, essential concepts that led to development of monoclonal antibody technology are outlined, including a short discussion on antibody structure and genetics. An overview of the theory of monoclonal antibody production is presented, as well as a comparison of the properties of monoclonal antibodies and conventional antisera. The paper concludes with a discussion of recent innovations in monoclonal antibody technology and their current and potential applications in animal agriculture.
ChemInform Abstract: DEAZAPURINE DERIVATIVES. XV. SYNTHESES OF SOME MONO‐ AND DIFLUOROIMIDAZO(4,5‐B)‐ AND ‐(4,5‐C)PYRIDINES (1976)

Abstract Die durch Umhalogenierung mit KF in DMSO bei 150°C aus den entsprechenden Chlor‐nitro‐Pyridinen in 55‐85%igen Ausbeuten erhältlichen Fluor‐nitro‐Pyridine (Ia), (Ib) und (Va) werden beim Behandeln mit NH 3 in 4‐Stellung zu den Aminen (IIa) und (IIb) bzw. in 2‐Stellung zu dem Amin (VIa) aminiert, während (Ic) [ = (Vb)] sowohl das 4‐ (IIc) als auch das 2‐Aminoderivat (VIb) zu gleichen Teilen gibt.
Casenotes: Torts — Defamation — Judicial Immunity — Absolute Immunity Afforded Potential Witnesses for Statements Published in Unfiled Documents Prepared for Possible Use in a Pending Judicial Proceeding. Adams v. Peck, 288 Md. 1, 415 A.2d 292 (1980) (1982)

administered' 6 or legal relations decided.' 7 The general rule in favor of free disclosure has also been extended to formal written matters filed in court. 1 8 Moreover, absolute immunity now applies to matters published during the formal pretrial discovery process 1 9 and to communications made informally during litigation. 2 B. The English and American RulesEnglish and American courts have developed two seemingly different rules concerning witness immunity that, in practice, often yield similar results. 2 The maxim that "[wiords spoken in a court of justice 16.
High-Performance, Air-Stable, Low-Temperature Processed Semitransparent Perovskite Solar Cells Enabled by Atomic Layer Deposition (2015)

We demonstrate high-performance, air-stable, low-temperature processed (≤100 °C) semitransparent (ST) perovskite solar cells (PSCs) by the applications of atomic layer deposition (ALD) technology to deposit ZnO and Al2O3 films as cathode buffer layer (CBL) and encapsulation layer, respectively. The application of ALD ZnO film as CBL in PSCs delivers several remarkable features, including fine-tunability of the work function of the electrode, low deposition temperature (80 °C), high charge selectivity, good electron-transporting ability (filed-effect mobility = 16.1 cm2 V–1 s–1), and excellent film coverage. With these desired interfacial properties, the device with opaque Ag electrode delivers high power conversion efficiency (PCE) up to 16.5%, greatly outperforming the device with state-of-the-art CBL ZnO nanoparticles film (10.8%). For ST PSCs employing Ag nanowires as transparent top electrode, a remarkable PCE of 10.8% with a corresponding average visible transmittance (AVT) of 25.5% is demonstrated, which represents the highest PCE ever reported for ST PSCs with similar AVT. More significantly, the insufficient ambient stability of ST device is significantly improved by employing excellent gas-barrier performance of ALD Al2O3-based encapsulation layer with an oxygen transmission rate of 1.9 × 10–3 cm3 m–2 day–1 and a water vapor transmittance rate of 9.0 × 10–4 g m–2 day–1.
NOZZLE: a defense against heap-spraying code injection attacks (2009)

Heap spraying is a security attack that increases the exploitability of memory corruption errors in type-unsafe applications. In a heap-spraying attack, an attacker coerces an application to allocate many objects containing malicious code in the heap, increasing the success rate of an exploit that jumps to a location within the heap. Because heap layout randomization necessitates new forms of attack, spraying has been used in many recent security exploits. Spraying is especially effective in web browsers, where the attacker can easily allocate the malicious objects using JavaScript embedded in a web page. In this paper, we describe NOZZLE, a runtime heap-spraying detector. NOZZLE examines individual objects in the heap, interpreting them as code and performing a static analysis on that code to detect malicious intent. To reduce false positives, we aggregate measurements across all heap objects and define a global heap health metric. We measure the effectiveness of NOZZLE by demonstrating that it successfully detects 12 published and 2,000 synthetically generated heap-spraying exploits. We also show that even with a detection threshold set six times lower than is required to detect published malicious attacks, NOZZLE reports no false positives when run over 150 popular Internet sites. Using sampling and concurrent scanning to reduce overhead, we show that the performance overhead of NOZZLE is less than 7 % on average. While NOZZLE currently targets heap-based spraying attacks, its techniques can be applied to any attack that attempts to fill the address space with malicious code objects (e.g., stack spraying [42]). 1
Preferential Lentiviral Targeting of Astrocytes in the Central Nervous System (2013)

The ability to visualize and genetically manipulate specific cell populations of the central nervous system (CNS) is fundamental to a better understanding of brain functions at the cellular and molecular levels. Tools to selectively target cells of the CNS include molecular genetics, imaging, and use of transgenic animals. However, these approaches are technically challenging, time consuming, and difficult to control. Viral-mediated targeting of cells in the CNS can be highly beneficial for studying and treating neurodegenerative diseases. Yet, despite specific marking of numerous cell types in the CNS, in vivo selective targeting of astrocytes has not been optimized. In this study, preferential targeting of astrocytes in the CNS was demonstrated using engineered lentiviruses that were pseudotyped with a modified Sindbis envelope and displayed anti-GLAST IgG on their surfaces as an attachment moiety. Viral tropism for astrocytes was initially verified in vitro in primary mixed glia cultures. When injected into the brains of mice, lentiviruses that displayed GLAST IgG on their surface, exhibited preferential astrocyte targeting, compared to pseudotyped lentiviruses that did not incorporate any IgG or that expressed a control isotype IgG. Overall, this approach is highly flexible and can be exploited to selectively target astrocytes or other cell types of the CNS. As such, it can open a window to visualize and genetically manipulate astrocytes or other cells of the CNS as means of research and treatment.
A 0.2V 0.44 ¿W 20 kHz Analog to Digital ¿¿ Modulator with 57 fJ/conversion FoM (2006)

This paper presents a 90 nm CMOS ΣΔ A/D modulator operating with a supply voltage of 0.2 V, well below the threshold voltage of the transistors. The modulator is an open-loop first-order architecture based on a frequency-modulated intermediate signal, generated in a ring voltage-controlled oscillator. The linearity of the modulator is greatly improved by the adoption of a so-called soft-rail in the oscillator. Measurements show a dynamic range of 52 dB over a 20 kHz signal bandwidth with a sampling frequency of 3.4 MHz, for a total power consumption as low as 0.44 μW. The corresponding peak SNDR is 44.2 dB, while the peak SNR is 47.4 dB.
Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis (2012)

This study investigated the antispasticity potential of Sativex in mice. Chronic relapsing experimental allergic encephalomyelitis was induced in adult ABH mice resulting in hind limb spasticity development. Vehicle, Sativex, and baclofen (as a positive control) were injected intravenously and the "stiffness" of limbs assessed by the resistance force against hind limb flexion. Vehicle alone caused no significant change in spasticity. Baclofen (5 mg/kg) induced approximately a 40% peak reduction in spasticity. Sativex dose dependently reduced spasticity; 5 mg/kg THC + 5 mg/kg CBD induced approximately a 20% peak reduction; 10 mg/kg THC + 10 mg/kg CBD produced approximately a 40% peak reduction in spasticity. Sativex has the potential to reduce spasticity in an experimental mouse model of multiple sclerosis (MS). Baclofen reduced spasticity and served as a positive control. Sativex (10 mg/kg) was just as effective as baclofen, providing supportive evidence for Sativex use in the treatment of spasticity in MS.
Choosing and Judging Teachers (2001)

Head teachers and student teachers have conceptions of what matters when selecting and judging the effectiveness of a new teacher. This study reports the results of surveys of sixty-six primary school head teachers' and eighty-one postgraduate student teachers' ratings of various criteria for selecting and judging new teachers. The data are consistent with those of similar surveys in the United States and there is a fairly high level of agreement between what the head teachers and the student teachers judged to be important. Nevertheless mismatches in conceptions of what matters can exist. Further, communication skills may benefit from explicit attention and treatment as a coherent whole in teacher training.
Analytical model for estimation of digging forces and specific energy of cable shovel (2013)

An analytical algorithm for the estimation of the resistance forces exerted on the dipper of a cable shovel and the specific energy consumed in the cutting-loading process is presented. Forces due to payload and to cutting of geomaterials under given initial conditions, cutting trajectory of the bucket, bucket's design, and geomaterial properties are analytically computed. The excavation process has been modeled by means of a kinematical shovel model, as well as of dynamic payload and cutting resistance models. For the calculation of the cutting forces, a logsandwich passive failure mechanism of the geomaterial is considered, as has been found by considering that a slip surface propagates like a mixed mode crack. Subsequently, the Upper-Bound theorem of Limit Analysis Theory is applied for the approximate calculation of the maximum reacting forces exerted on the dipper of the cable shovel. This algorithm has been implemented into an Excel<TEX>$^{TM}$</TEX> spreadsheet to facilitate user-friendly, "transparent" calculations and built-in data analysis techniques. Its use is demonstrated with a realistic application of a medium-sized shovel. It was found, among others, that the specific energy of cutting exhibits a size effect, such that it decreases as the (-1)-power of the cutting depth for the considered example application.
Fast computation of concept lattices using data mining techniques (2000)

We present a new algorithm called Titanic for computing concept lattices. It is based on data mining techniques for computing frequent itemsets. The algorithm is experimentally evaluated and compared with B. Ganter&apos;s Next-Closure algorithm.
Preventive Veterinary Medicine Resources and Their Exploitation in Internet (2000)

Internet is becoming more and more important in preventive veterinary medicine research.This makes it possible for preventive veterinary mediciner to do their research by international cooperation and thus to probe deeply into the essence of preventive veterinary medicine.Preventive veterinary medicine resources in the Internet include the following aspects:(1)virtual library and information resources centre;(2)virtual veterinary hospital and virtual laboratory;(3)academic research organization;(4)learned society and organization;(5)learned journal and electronic publishations;(6)electronic forums and educational resources.In this paper the authors not only enclose many classified preventive veterinary medicine resources addresses,but also point out some ways to access the Internet efficiently.
Conditions for soft x-ray lasing action in a confined plasma column (1980)

The idea of using a multi-Z (e.g., carbon, oxygen) thin plasma column as a medium for soft x-ray lasing action is presented. A plasma confined by a strong magnetic field is first heated by a CO2 laser, and then cools rapidly by radiation losses. This leads to a level population inversion of hydrogen-like carbon or oxygen ions. Two computational models are presented. One uses given electron temperature Te(t) evolutions. The other uses Te(t) calculated from an energy balance equation with CO2 laser beam power as a parameter. According to calculations, a total gain of G≳100 is expected for 3→2 and G≳10 for 4→2 transitions (λ=182 Å and λ=135 Å, respectively) for C VI ions using a CO2 laser beam with power ∼5×1010 W for plasma column heating.