gebhart/patrepeval huggingface dataset:
Nitrones as therapeutics in age‐related diseases (2006)

Age-related diseases deprive individuals of a higher quality of life and therefore therapeutics for their treatment provide significant potential. An overview of the observations of nitrones as potential therapeutics in several age-related diseases is presented. Treatment of acute ischemic stroke is one condition where a nitrone (NXY-059) is in late phase 3 clinical trials now. Also presented is a summary of the most recent work we have accomplished on the anticancer activity of the nitrones in a hepatocellular carcinoma. The mechanistic basis of action of these compounds in several animal models is not yet understood at the molecular levels; however, it does appear clear that their anti-inflammatory properties are central to their action, which is based on their ability to down-regulate exacerbated signal transduction processes.
Multi-objective approach for the automatic design of optical systems (2016)

An innovative method for the automatic design of optical systems is presented and verified. The proposed method is based on a multi-objective evolutionary memetic optimization algorithm. The multi-objective approach simultaneously, but separately, addresses the image quality, tolerance, and complexity of the system. The memetic technique breaks down the search for optical designs in to three different parts or phases: optical glass selection, exploration, and exploitation. The optical glass selection phase defines the most appropriate set of glasses for the system under design. The glass selection phase limits the available glasses from hundreds to just a few, drastically reducing the design space and significantly increasing the efficiency of the automatic design method. The exploration phase is based on an evolutionary algorithm (EA), more specifically, on a problem-tailored generalized extremal optimization (GEO) algorithm, named Optical GEO (O-GEO). The new EA incorporates many features customized for lens design, such as optical system codification and diversity operators. The trade-off systems found in the exploration phase are refined by a local search, based on the damped least square method in the exploitation phase. As a result, the method returns a set of trade-off solutions, generating a Pareto front. Our method delivers alternative and useful insights for the compromise solutions in a lens design problem. The efficiency of the proposed method is verified through real-world examples, showing excellent results for the tested problems.
Continuous Process for Ammonium-Lactate Fermentation of Deproteinized Whey (1979)

A mathematical model was developed to describe a process for the continuous fermentation of lactose to lactic acid with neutralization to a constant pH by ammonia. Equations for the steady state were used to simulate the effect of cell-retention time on substrate, product, and cell-mass concentrations in a singlestage system. The theoretical predictions then were validated by laboratory experiments in which reconstituted and supplemented deproteinized whey was fermented continuously by an adapted culture of Lactobacillus bulgaricus at pH 5.5 and 44 C without sterilization or asepsis. Lactate concentration was maximum (58.7 mg/ml) at a cell-retention time of 27 h, and cell mass was maximum (1.9 mg/ml) at 9.3 h. The single-stage continuous fermentation of deproteinized whey as compared to that of whole whey resulted in similarly high product accumulation and of substrate utilization at similarly high conversion rates. The fermentation of deproteinized whey also was simulated for operation with two stages in series at various retention-time ratios, the results of which predicted that the combined retention time could be reduced to 17 h with results as good as that with the single-stage operation.
Neuronavigation: concept, techniques and applications. (2002)

Neuronavigation provides intraoperative orientation to the surgeon, helps in planning a precise surgical approach to the targetted lesion and defines the surrounding neurovascular structures. Incorporation of the functional data provided by functional MRI and magnetoencephalography (MEG) with neuronavigation helps to avoid the eloquent areas of the brain during surgery. An intraoperative MRI enables radical resection of the lesions, the possibility of immediate control for tumor remnants and updates of neuronavigation with intraoperative images to compensate for brain shift. In this study, the experience of 432 patients undergoing neuronavigation assisted neurosurgical interventions using either the pointer-based or microscope-based navigational systems at the University of Erlangen-Nuremberg, Germany is presented. The procedures included stereotactic biopsy (n=53), stereotactic cyst puncture/ventricular drainage (n=15), eloquent cortex/tumor localization to facilitate tumor resection, assessment of neurovascular structures in the vicinity of tumors of the sellar-suprasellar regions, skull base, posterior fossa and ventricular region (n=252), and, surgery for epilepsy (n=9). Functional brain mapping using fMRI and MEG and their integration with neuronavigation was carried out in 24 and 128 patients respectively. The simultaneous use of intraoperative MRI to look for the remaining tumor was done in 159 patients and the update of navigational data was carried out in 17 patients. The mean system accuracy obtained by using both the fiducial registration as well as anatomical landmark-surface fitting computer algorithm was 1.81 mm. This study reviews the relative merits and demerits of the pointer and microscope based navigational systems and also highlights the role of functional brain mapping and intraoperative MRI, when integrated with neuronavigation, in the surgical decision-making to offer the chances of more radical resections with minimal morbidity.
Hormone-refractory prostate cancer: choosing the appropriate treatment option. (2007)

Hormone-refractory prostate cancer (HRCaP) is both heterogeneous and lethal. Multiple treatment options exist, including secondary hormonal manipulations, chemotherapy, experimental options, and best supportive care. Choosing the appropriate therapy for an individual patient depends on several important clinical factors such as the presence or absence of symptomatic metastatic disease, age and comorbidities, and prostate-specific antigen velocity. While only docetaxel (Taxotere)-based chemotherapy has been proven to improve survival in this setting, a wide range of therapies may be effective for any individual. Palliative maneuvers, such as external-beam radiation, bisphosphonate therapy, radiopharmaceuticals, and pain management are critical for appropriate patient management. Several promising novel therapies are in late-stage testing and will hopefully provide more treatment options for these patients.
Two-Level Buffer State Report Scheme for 3GPP LTE System (2009)

Taking the uplink scheduling technique in 3GPP LTE system into consideration, the two-level buffer state report (BSR) scheme is proposed as a better candidate solution for uplink resource allocation in LTE system and future beyond third-generation system. In the proposed two-level scheme, the second level BSR content is a complement information of the BSR in LTE system which is regarded as the first level BSR to indicate the relation state about buffer size and the relative token bucket number of radio bearer (RB), and it can improve the utilization of radio resources and meet the QoS requirements of traffics in scenario of multiple users with multiple radio bearers without extra signaling overhead.
A Real-time Hand Gesture Recognition and Human-Computer Interaction System (2017)

In this project, we design a real-time human-computer interaction system based on hand gesture. The whole system consists of three components: hand detection, gesture recognition and human-computer interaction (HCI) based on recognition; and realizes the robust control of mouse and keyboard events with a higher accuracy of gesture recognition. Specifically, we use the convolutional neural network (CNN) to recognize gestures and makes it attainable to identify relatively complex gestures using only one cheap monocular camera. We introduce the Kalman filter to estimate the hand position based on which the mouse cursor control is realized in a stable and smooth way. During the HCI stage, we develop a simple strategy to avoid the false recognition caused by noises - mostly transient, false gestures, and thus to improve the reliability of interaction. The developed system is highly extendable and can be used in human-robotic or other human-machine interaction scenarios with more complex command formats rather than just mouse and keyboard events.
Serum and plasma compared for use in 19 common chemical tests performed in the Hitachi 737 analyzer. (1989)

Journal Article Serum and plasma compared for use in 19 common chemical tests performed in the Hitachi 737 analyzer. Get access R Ciuti, R Ciuti Search for other works by this author on: Oxford Academic Google Scholar G Rinaldi G Rinaldi Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 35, Issue 7, 1 July 1989, Pages 1562–1563, https://doi.org/10.1093/clinchem/35.7.1562 Published: 01 July 1989
Alpha 1-adrenoreceptor blockade and the molecular basis of lipid metabolism alterations. (1990)

For the past 40 years, adrenoreceptors have been studied as the biomolecular mediators of tissue response to catecholamines. An expanded role of alpha-adrenoreceptors in the regulation of risk factors for coronary heart disease (CHD) has recently emerged. Hypercholesterolaemia, hypertension, and cigarette smoking are the major risk factors and their interactions are associated with increased mortality. Control of hypertension alone has failed to reduce the risk of CHD. Conversely, reduction of elevated total cholesterol and low density lipoprotein (LDL)-cholesterol has been shown to lower the risk of CHD. As a result, multiple risk factor approaches to the management of patients have evolved in attempts to reduce deaths from CHD. Selective alpha 1-adrenoreceptor antagonists appear to have a dual function in CHD risk management since they control elevated blood pressure by peripheral vasodilatation and reduce atherogenic lipids by several mechanisms. With selective alpha 1-blockade, the number of LDL-cholesterol receptors is up-regulated and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG Co-A reductase) activity is suppressed causing reductions in total cholesterol, LDL-cholesterol, and apoprotein B levels. Effects on intermediary metabolism reduce synthesis of very low density lipoprotein (VLDL) which contributes to a reduction of total triglyceride levels and, to a lesser extent, to a reduction of total cholesterol levels. Increased lipoprotein lipase activity leads to reduced total triglyceride and VLDL levels and to increased high density lipoprotein (HDL)-cholesterol levels. As demonstrated by the initial prospective data from Phase I of the Treatment of Mild Hypertension Study (TOMHS), both reduction of raised blood pressure and beneficial lipid modifications are sustained (1 year) with selective alpha 1-blockade. The prospective benefits on morbidity and mortality from CHD of such favourable changes in these two major risk factors remain to be quantified.
The major surface protein of Leishmania promastigotes is a protease. (1986)

The major surface protein of Leishmania promastigotes is evolutionarily conserved and is found in isolates of L. donovani, L. major, L. tropica, L. mexicana, and L. braziliensis. The data provided in this communication demonstrate that in L. major this integral membrane protein is a protease, which we now designate promastigote surface protease. The enzyme has an alkaline pH optimum and is active both in its detergent-solubilized form and at the surface of living or fixed promastigotes. A water-soluble form of promastigote surface protease is obtained following digestion with the phospholipase C responsible for the release of the variant surface glycoprotein of Trypanosoma brucei. Possible biological functions of promastigote surface protease during the life cycle of Leishmania parasites are discussed.
SARS-CoV-2 detection with CRISPR diagnostics (2020)

Abstract The novel coronavirus (CoV) disease termed COVID-19 (Coronavirus Disease-19) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) is causing a massive pandemic worldwide, threatening public health systems across the globe. During this ongoing COVID-19 outbreak, nucleic acid detection has played an important role in early diagnosis. Here we report a SARS-CoV-2 detection protocol using a CRISPR-based CRISPR diagnostic platform - CDetection (Cas12b-mediated DNA detection). By combining sample treatment protocols and nucleic acid amplification methods with CDetection, we have established an integrated viral nucleic acid detection platform - CASdetec (CRISPR-assisted detection). The detection limit of CASdetec for SARS-CoV-2 pseudovirus is 1 × 10 4 copies/mL, with no cross reactivity observed. Our assay design and optimization process can provide guidance for future CRISPR-based nucleic acid detection assay development and optimization.
MOBDroid: An Intelligent Malware Detection System for Improved Data Security in Mobile Cloud Computing Environments (2020)

We propose an intelligent malware detection system (MOBDroid) that aims to protect the end-user's mobile device (MD) in mobile cloud computing (MCC) environment. MOBDroid utilizes the Android Operating System (OS) permission-based security system. The APK files of 28,306 benign and malicious applications (apps) collected from the AndroZoo and RmvDroid malware repositories were used in the system development process. The apps were decompiled in order to extract their manifest files and construct a dataset comprising the permissions requested by each of the apps. We identified some unique permissions that could be used to distinguish between malicious and benign apps and performed a series of experiments using a machine learning (ML) model; the model drew on the ML.net library and was implemented in C#.net. In the experiments conducted, we obtained classification accuracy of 96.89%, a detection rate of 98.65%, and false negative rate of 1.35%. The results indicate that our model compares very favorably to other models reported in the extant literature.
Characterization of optical and mechanical modification of surface alignment layers for liquid crystal devices (2001)

Reliable performance of liquid crystal (LC) materials in display applications is critically dependent on the behavior of surface treatments that induce molecular alignment parallel to the cell windows. While general understanding of the nature of this effect has been available for some time, the detailed characteristics of the LC-surface interaction are not sufficiently well understood to enable reliable interface engineering. This is particularly true for new materials that might otherwise possess favorable qualities but cannot be reproducibly oriented in a device. Our work is concentrated on understanding optical and mechanical modification of organic monolayers that have been self- assembled on dielectric surfaces. We use vibrationally resonant sum-frequency generation and ellipsometry as well as non-optical techniques, such as contact angle testing, to evaluate the influence of these perturbations. We have been able to follow subtle conformation changes as well as more dramatic photochemical effects. The results help reveal the anchoring mechanisms and provide insight into ways of tailoring interfaces for new materials.
A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-II. (1985)

Bovine brain, hypothalamus, pituitary, and retina contain potent anionic polypeptide mitogens for endothelial cells. Immunological assays using murine monoclonal antibodies against bovine endothelial cell growth factor (ECGF) and radioreceptor assays using [125I]ECGF were performed to determine the cross-reactivity of ECGF with bovine acidic pI brain-derived fibroblast growth factor (acidic FGF) and bovine eye-derived growth factor-II [EDGF-II). We observed that acidic FGF and EDGF-II are recognized by anti-ECGF monoclonal antibodies and compete with [125I] ECGF for receptor occupancy. Furthermore, the biological activity of ECGF, acidic FGF, and EDGF-II is potentiated by the glycosaminoglycan, heparin. These results argue that ECGF, acidic FGF, and EDGF-II belong to a common family of polypeptide growth factors.
Rate-Limiting Steps in Oxidations Catalyzed by Rabbit Cytochrome P450 1A2 (2004)

Several issues regarding the rate-limiting nature of individual reaction steps in catalysis by rabbit liver cytochrome P450 (P450) 1A2 were addressed using anisoles and other substrates. Substrate binding is very fast (k > 10(6) M(-1) s(-1)). Product release is not rate-limiting, as shown by the absence of bursts, placing rate-limiting steps at or before product formation. We had previously shown that the first 1-electron reduction step is fast (k > 700 min(-1)), even in the absence of ligand [Guengerich, F. P., and Johnson, W. W. (1997) Biochemistry 36, 14741-147500]. O(2) binding to ferrous P450 is fast (k >/= 10(6) M(-1) s(-1)). The decay of the P450 Fe(2+)-substrate-O(2) complex was slow in the absence of NADPH-P450 reductase, with a first-order rate constant of 14 min(-1) at 25 degrees C. During the decay, product was formed (from the substrate methacetin) in 61% theoretical yield, although this reaction requires electron transfer among P450 molecules and may not be related to normal turnover. Steady-state spectra suggest that one or more iron-oxygen complexes accumulate, representing entities between the Fe(2+)-O(2) complex and putative FeO(3+) entity. Kinetic isotope effect experiments were done with several substrates, mainly anisoles. Apparent intrinsic deuterium isotope effects as high as 15 were measured. In all cases, the C-H bond-breaking step is at least partially rate-limiting. The isotope effects were not strongly attenuated in noncompetitive or competitive experiments, consistent with relatively rapid P450-substrate exchange, except with the active enzyme Fe-O complex. Kinetic simulations with the available data (i) are consistent with the view that C-H bond breaking is a major rate-limiting step, (ii) demonstrate that increasing the rate of this step will affect k(cat), K(m), and kinetic hydrogen isotope effects but will only increase catalytic efficiency to a certain degree, (iii) indicate that increasing ground-state binding can increase catalytic efficiency but not k(cat), and (iv) suggest that nonproductive binding modes and abortive reduction of O(2) are factors that attenuate catalytic efficiency.
Pretranslational mechanisms determine the type of potassium channels expressed in the rat skeletal and cardiac muscles (1991)

We have cloned a cDNA (RMK2) coding for a Shaker type delayed rectifier K+ channel from a rat skeletal muscle cDNA library. The clone encodes a putative protein of 602 amino acids, identical with a rat brain K+ channel Kv1 (Swanson, R., Marshall, R., Smith, J. S., Williams, J. B., Boyle, M. B., Folander, K., Luneau, C. J., Antanavage, J., Oliva, C., Burhow, S. A., Bennet, C., Stein, R. B., and Kaczmarek, L. K. (1990) Neuron 4, 929-939). Northern blot analysis showed that RMK2 is expressed in skeletal and cardiac muscle. RNase protection analysis showed that the 3'-noncoding regions of the brain, cardiac, and skeletal muscle RMK2 transcripts are identical. Cloning of the gene confirmed that the protein is encoded by a single exon (Swanson et al. (1990) Neuron 4, 929-939). We expressed RMK2 in Xenopus oocytes and showed that it encodes noninactivating delayed rectifier K+ channels, resistant to block by external tetraethylammonium, with a small unitary conductance of 8.0 picosiemens. Coinjection of RMK2 and RCK1 (RMK1) (Baumann, A., Grupe, A., Ackermann, A., and Pongs, O. (1988) EMBO J. 7, 2457-2463; Koren, G., Liman, E. R., Logothetis, D. E., Nadal-Ginard, B., and Hess, P. (1990) Neuron 4, 39-51) into Xenopus oocytes resulted in the expression of currents that have tetraethylammonium inhibition curves that differ from the linear combination of inhibition curves of the two types expressed individually. Thus, RMK2 and RCK1 (RMK1) can form heteromultimers. RNA blot hybridization analysis revealed that the RMK2 transcript is developmentally regulated in a different manner in the rat skeletal muscle, ventricle, and atrium.
Effects of quercetin on the expression of MCP-1, MMP-9 and VEGF in rats with diabetic retinopathy (2017)

Diabetic retinopathy, a severe complication of diabetes, is the leading cause of blindness in the developed world. This study investigated the effects of quercetin on levels of monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in serum of rats with diabetic retinopathy, and explored the functional mechanisms of quercetin in the treatment of diabetic retinopathy. Twenty rats with induced diabetes were divided into a model group and a quercetin group, with 10 rats in each group. Ten healthy rats were also included to serve as a control group. Rats in the quercetin group were treated with an intragastric injection of quercetin (150 mg/kg), while the same amount of sodium carboxymethyl cellulose (CMCNa) was used for rats in the model group and the control group. The treatment was performed once per day and blood glucose was measured in each group at 0, 10 and 20 weeks after the first treatment. Blood glucose tests showed that quercetin did not reduce blood glucose in rats with diabetes. However, pathological examination showed that quercetin could relieve pathological changes caused by diabetes, such as retinal edema and vacuoles. ELISA results showed that, compared with the control group, levels of MCP-1, MMP-9 and VEGF in the model group were significantly increased (P<0.01). No significant difference in serum MCP-1 content was found between the model group and the quercetin group, but levels of MMP-9 and VEGF were significantly decreased in the quercetin group (P<0.01). Results of RT-PCR and western blot analysis showed that, compared with the control group, levels of MCP-1, MMP-9 and VEGF mRNA and protein in the retinal tissue of rats in the model group were significantly increased (P<0.01). No significant differences in expression levels of MCP-1 mRNA and protein were found between the model group and the quercetin group, but levels of MMP-9 and VEGF mRNA and protein were significantly decreased in the quercetin group (P<0.01). Quercetin has a certain therapeutic effect on rats with diabetic retinopathy and its effect may be achieved by reducing the expression of MMP-9 and VEGF, but not the inflammatory mediator, MCP-1.
ChemInform Abstract: CC‐1065 and the Duocarmycins: Synthetic Studies (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.