gebhart/patrepeval huggingface dataset:
Potential targets for ovarian clear cell carcinoma: a review of updates and future perspectives (2015)

Advances in surgical and medical treatments for ovarian cancer have improved prognoses. Platinum drugs in particular are pivotal for the medical treatment of ovarian cancer. However, previous studies have revealed that some histological subtypes, such as clear cell carcinoma, are resistant to medical treatment, including that with platinum drugs. Consequently, the clinical prognosis of advanced clear cell carcinoma is remarkably inferior, primarily because of its chemoresistant behavior. The prevalence of clear cell carcinoma is approximately 5 % in the West, but in Japan, its prevalence is particularly high, at approximately 25 %. Current medical treatments for advanced clear cell carcinoma are difficult to administer, and they have poor efficacy, warranting the development of novel target-based therapies. In this review, we describe medical treatments for clear cell carcinoma and discuss future prospects for therapy. In particular, we focus on the mechanism of platinum resistance in clear cell carcinoma, including the role of annexin A4, one of the most investigated factors of platinum resistance, as well as the mutant genes and overexpressed proteins such as VEGF, PI3K/AKT/mTOR signaling pathway, ARID1A, hepatocyte nuclear factor-1β, ZNF217. We also review targeted molecular therapeutics for epithelial ovarian cancer and discuss their role in clear cell carcinoma treatment. We review the drugs targeting angiogenesis (bevacizumab, sorafenib, and pazopanib), growth factors (gefitinib, erlotinib, lapatinib, trastuzumab, and AMG479), and signaling pathways (temsirolimus, dasatinib, and imatinib), and other drugs (oregovomab, volociximab, and iniparib). This current review summarizes and discusses the clinical significance of these factors in ovarian clear cell carcinoma as well as their potential mechanisms of action. It may provide new integrative understanding for future studies on their exact role in ovarian clear cell carcinoma.
A Bayesian model averaging approach to the dumping severity data over hierarchical log-linear models (2014)

In this article, we consider a Bayesian model averaging approach for hierarchical log-linear models to analyse the "dumping severity" dataset from the Bayesian perspective.A wide range of log-linear models fits this dataset well when analyzed with classical approaches.However, only one log-linear model is determined to fit the dataset well by the Bayesian model averaging approach.Therefore, use of the BMA approach for this dataset is found to be more advantageous than classical model selection approaches.
[Synthesis and antidepressive effects of diaryl-4,6-amino-3-pyridazine analogs of minaprine]. (1988)

The reaction of 3-chloro pyridazines with various amines led to a series of minaprine analogues. Most of them exhibited significant antidepressant activity. The influence of the substituents attached to the pyridazine ring was discussed.
Editorial: Introduction to the Special Issue on Multimedia Data Mining (2008)

The twelve papers in this special issue focus on multimedia data mining. The special issue evolved from a successful workshop organized in conjunction with the 2006 ACM KDD conference, but the special issue was open to the whole community.
Surface tension determination by means of liquid handling stations (2016)

The characterization of liquid surfaces with respect to surface tension is of major interest throughout a number of disciplines. In life science technologies and in pharmaceutical production in particular, the surface tension and drop size of liquids are predominating parameters throughout the production process, starting from foaming during fermentation processes, formulation by spray drying, or the drug application by aerosol inhalators. The profiling of surface tension can be further applied for physicochemical drug assessment with predictive power for the compound's pharmacology. In the present study, a high‐throughput approach for the determination of surface tension integrated into a fully automated liquid handling station was developed. The method is based on the accurate gravimetric determination of masses of drops generated at a liquid handler tip using a high‐precision balance. By means of repetitive sample‐conserving drop‐generating procedures, huge numbers of drops and thus statistical significance can be created from a minimal sample volume of a few 100 μL. The developed approach excels in instrumental simplicity, accuracy, precision, and minimal sample consumption. The fully automated setup was validated for a broad range of surface tensions starting from about 25 to 75 mN/m. Eight‐fold determinations of sample liquids exposed standard deviations of less than 0.5%, which demonstrates excellent precision. Further potential revisions of the stalagmometric approach for the determination of interfacial tension between two liquids are described in detail. The employment of liquid handling stations enables the integration of the developed method into the high‐throughput screening paradigm and thus adds high value to the laboratory work flow.
Evaluation of digital real-time PCR assay as a molecular diagnostic tool for single-cell analysis (2018)

In a single-cell study, isolating and identifying single cells are essential, but these processes often require a large investment of time or money. The aim of this study was to isolate and analyse single cells using a novel platform, the PanelChip™ Analysis System, which includes 2500 microwells chip and a digital real-time polymerase chain reaction (dqPCR) assay, in comparison with a standard PCR (qPCR) assay. Through the serial dilution of a known concentration standard, namely pUC19, the accuracy and sensitivity levels of two methodologies were compared. The two systems were tested on the basis of expression levels of the genetic markers vimentin, E-cadherin, N-cadherin and GAPDH in A549 lung carcinoma cells at two known concentrations. Furthermore, the influence of a known PCR inhibitor commonly found in blood samples, heparin, was evaluated in both methodologies. Finally, mathematical models were proposed and separation method of single cells was verified; moreover, gene expression levels during epithelial-mesenchymal transition in single cells under TGFβ1 treatment were measured. The drawn conclusion is that dqPCR performed using PanelChip™ is superior to the standard qPCR in terms of sensitivity, precision, and heparin tolerance. The dqPCR assay is a potential tool for clinical diagnosis and single-cell applications.
Sample Design for Longitudinal Surveys (2009)

This chapter contains sections titled: Introduction Types of Longitudinal Sample Design Fundamental Aspects of Sample Design Other Aspects of Design and Implementation Conclusion References
Synthesis of the nucleoside antiobiotic nucleocidin (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of the nucleoside antiobiotic nucleocidinJ. G. Moffatt, I. D. Jenkins, and J. P. H. VerheydenCite this: J. Am. Chem. Soc. 1971, 93, 17, 4323–4324Publication Date (Print):August 1, 1971Publication History Published online1 May 2002Published inissue 1 August 1971https://pubs.acs.org/doi/10.1021/ja00746a056https://doi.org/10.1021/ja00746a056research-articleACS PublicationsRequest reuse permissionsArticle Views707Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasma/intestinal Concentration Patterns Suggestive of Entero-Portal Recirculation of Amino Acids: Effects of Oral Administration of Asparaginase, Glutaminase and Tyrosinase Immobilized by Microencapsulation in Artificial Cells (1988)

This study suggests the presence of an entero-portal recirculation of amino acids. Endogenous sources of amino acids are secreted at high concentration into the small intestine. Most of the amino acids are absorbed as the content passes down the small intestine. Plasma amino acid concentrations are on the average only 1-5% of the concentrations in the duodunum. This is true even in rats on 24 hours of water and sugar with no exogenous sources of amino acids. For example, the PLASMA:DUODENUM concentrations (mumole/litre) are: Asparagine 37:7164, Tyrosine 94:9579, and glutamine/histidine 409:9708. This entero-portal recirculation of amino acids means the potential of a method for specific depletion of body amino acids by oral ingestion of bioreactants like immobilized enzymes. Preliminary studies used artificial cells to immobilize asparaginase,glutaminase and tyrosinase by microencapsulation. Six hours after 1 oral administration, asparagine, glutamine and tyrosine in the ileum were lowered to 10% of the level of the control. Artificial cells containing no enzymes were used as the control.
Thermotherapy for Control of Fungal Pathogens in Propagative Rootstocks of Horseradish (2010)

This study was conducted to develop a reliable method for control of set-borne inoculum of Verticillium and Fusarium species that cause the internal discoloration of horseradish roots. Horseradish propagative root stocks (sets), 0.5 to 3.0 cm in diameter and 20 to 25 cm long, were treated by immersing them into water at 44, 45, 46, 47, 48, 49, and 50 °C for 10, 20, and 30 min. Treated and untreated sets were cultured on acidified potato dextrose agar to determine the presence of the pathogens in the sets. Treatments at temperatures lower than 46 °C did not control the set-borne inoculum of the pathogens. Treated and untreated sets were also planted in the greenhouse and fields to assess the effects of the thermotherapy on germination of the sets and vigor of the plants. Treatments at 48 °C or greater either delayed or reduced set germination and reduced plant vigor. The most effective treatment for control of the set-borne pathogens without adverse effects on set germination or plant vigor was determined to be 47 °C for 20 min.
dc electric field meter with fiber-optic readout (1986)

The design of a dc electric field meter capable of measuring the magnitude and direction of the electric field at an arbitrary location above the ground plane is described. The meter is based on measuring induced charge on a split cylindrical electrode pair which is rotated around its axis of symmetry. Data readout is by fiber-optic cable using pulse frequency encoding. The sensing head is electrically isolated. Initial results are reported from a series of tests at General Electric’s High Voltage Transmission Research Facility, Pittsfield, MA. The electric field was measured in a large test cage and under a dc test line. Measurement of field magnitude and direction around a human subject standing under the conductor was demonstrated.
Dual OS Support Peripheral Device Encapsulation (2008)

The need of extensive computing capacity is expanding all the time. Especially in company providing network service, adding servers physically requires much more cost. Also in embedded system, resource is also very limited. That is why virtulization is so popular in research and industry application. A lot of virtulization technique is raised to supply great computing capacity with multiple operating system running synchronously in a single real machine. Of all the aspects affecting real time performance of a computer, I/O processing has played a major role. Because I/O bound process has to wait for device to be free and thus increase response time which may delay them go beyond deadline. The system-on-a-chip technology provides the scratch-pad memory(SPM), which is small, isolated and located on chip. We implement a little operating system running in SPM (SPMOS). The SPMOS provide virtual I/O interface for general operating system. Different I/O requestis buffered and scheduled if necessary. Also, with proper memory checking mechanism, we could prevent malicious attacks on SPM, which means that any program running in the SPM could be protected effectively. Experiment shows that the SPMOS based virtual I/O interface is efficient and practical.
VIRTERF, a vision on heritage conservation (2002)

The VIRTERF prototype combines recent developments in computer vision and reverse engineering with specific needs of professionals working in the field of architectural conservation. The development of the software is explained as based on requirements of possible end-users. Image based modelling techniques using automatic correspondence analysis, reverse engineering modelling and a layer-like annotation technique in a CAD environment are developed that tailor the needs of those professionals in terms of precision, of the nature of the documentation. The prototype programme has been tested on a number of case studies and those applications have revealed its strong and weak points.
Ion Chromatographic Analysis of Trace Ions in Environmental Samples (1979)

Ion Chromatography (IC) is a new ion-exchange, liquid chromatographic technique which was developed by H. Small, T. Stevens and W. Bauman (1) of the Dow Chemical Co. This technique overcomes the problems of separation and detection of highly acidic or basic ions. Thus, the power of high speed liquid chromatographic separation can now be applied to analytical problems involving these types of ions. A number of these species are of concern to the EPA because they are environmental pollutants. In general, IC can be used to separate and detect ions whose dissociation constant (pK) is less than 7. Because of its exceptional selectivity, sensitivity and speed, IC is particularly suited to applications involving analysis of anions and cations in wastewater, natural waters, source effluents, workplace environments, ambient air and rain water. The analysis of organic as well as inorganic ions can be performed by IC. Table I is a growing
Synthesis, Structures and Ethylene Polymerisation Behaviour of Low Valent β-Diketiminato Chromium Complexes (2001)

The preparation, reaction chemistry and ethylene polymerisation behaviour of low valent β-diketiminato chromium complexes are described. [(DDP)CrCl(µ-Cl)]2 (1) [DDPH = 2-{(2,6diisopropylphenyl)amino}-4-{(2,6-diisopropylphenyl)imino}pent-2-ene] is formed by treatment of CrCl3(THF)3 with LiDDP. Alkylation of 1 with AlMe3 results in the formation of the binuclear dimethyl complex [(DDP)CrMe(µ-Cl)]2 (2). In contrast, the attempted alkylation of 1 with benzylmagnesium chloride results in reduction to form the dichromium(II) complex [(DDP)Cr(µ-Cl)]2 (3). Depending on the conditions of crystallisation, 3 can be obtained as the THF adduct [3(THF)2·THF] or co-crystallised with a molecule of dibenzyl [3·Bz-Bz]. Cleavage of the dimeric unit in 1 can be achieved by the addition of carboxylates or β-diketonates to give [(DDP)CrCl(O2CR)(THF)] (R = Me 4a, Ph 4b) and [(DDP)CrCl({O(R)C}2CH)] (R = Me 5a, Ph 5b), respectively. Single crystal X-ray diffraction studies have been performed on 1, 2, 3(THF)2·THF, 3·Bz-Bz, 4a, and 5b. Complexes 1, 2 and 3(THF)2·THF are dimeric and have molecular C2h symmetry. Complex 3·Bz Bz is also dimeric but has its potential C2h symmetry removed by a significant tetrahedral distortion of the chromium coordination geometry. Compound 4a has an octahedral chromium centre coordinated to a single bidentate diketiminate ligand, a bidentate acetate, a chloride and a THF molecule. Complex 5b has a square pyramidal chromium with apical chloride and basal η2 diketiminate and diketonate ligands. The complex contains strong intramolecular C−H···π stabilising interactions. All the complexes are active in ethylene polymerisation on treatment with suitable aluminium activators, affording high molecular weight polyethylene.
Early panretinal photocoagulation for ERG‐verified ischaemic central retinal vein occlusion (2011)

This study indicates that ocular NV in patients with CRVO can be predicted by photopic 30 Hz flicker ERG and that early PRP in ERG-verified ischaemic CRVO could be suggested as standard treatment.
&nbsp;&alpha;-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies (2012)

This paper attempts to predict and emphasize molecular interactions of dopamine, levodopa, and their derivatives (Dopimid compounds) containing 2-phenyl-imidazopyridine moiety with the α-cyclodextrin dimer in order to assess and improve drug delivery to the central nervous system. The molecular docking method is used to determine the energetic profiles, hydrogen bond formation, and hydrophobic effect of 14 host-guest complexes. The results show that the "chemical branching" represented by additional ethyl-acetate residue is energetically unfavorable and promotes a conformational shift due to the high root mean square deviation levels. This phenomenon is characterized by a low number of H-bonds and a significant decrease of the host-guest hydrophobic potential surface. Finally, the overall docking procedure presents a powerful rationale for screening and analyzing various sets of promising drug-like chemical compounds in the fields of supramolecular chemistry, molecular sensing, synthetic receptors, and nanobiotechnology.
Contactless energy transfer through air by means of ultrasound (2011)

An alternative approach to the wireless transfer of energy is proposed, employing acoustic waves in air. Unlike conventional methods, acoustic energy transfer is able to achieve energy transfer at high efficiencies over distances that are large in comparison to the dimensions of the transmitter and the receiver. This paper gives an overview of the principle and explains the different loss mechanisms that come into play. A theoretically limit on the achievable efficiency is calculated. It exceeds that of a comparable inductively coupled system by an order of magnitude. First preliminary measurements indicate that AET is feasible, although the measured efficiency is lower than the predicted theoretical limit.
Computer analysis of implanted cardiac pacemaker rhythm (2007)

Implanted cardiac pacemakers are becoming more sophisticated. However, accurate detection of pacemaker stimuli is a problem for most ECG machines because of the very short duration of the stimuli, sometimes only 0.3ms. In addition, the relatively new technique of biventricular pacing involves two closely timed stimuli to activate the ventricles separately. Detection of all stimuli in a paced patient is therefore becoming increasingly difficult for conventional ECG machines. In order to address this problem, a more recently developed electrocardiograph, namely the Burdick Atria 6100, introduced enhanced front end electronics. This study assessed its accuracy in detecting pacemaker stimuli and assessed the choice of lead for their detection. 51 patients were initially recruited. Five were excluded for various reasons. Pacemaker activity was detected in 45/46 patients and in 16/16 patients with biventricular pacemakers, two closely paced stimuli were detected.
Inter-AS traffic engineering with SDN (2017)

Egress selection in an Internet Service Provider (ISP) is the process of selecting an egress router to route interdomain traffic across the ISP such that a traffic engineering objective is achieved. In traditional ISP networks, traffic through the ISP is carried through the network and exits via an egress that is closest to the source in an attempt to minimize network resources for transit traffic. This exit strategy is known as Hot Potato Routing (HPR). The emerging field of Software-Defined Networking (SDN) has opened up many possibilities and promised to bring new flexibility to the rigid traditional paradigm of networking. In an ISP network, however, completely replacing legacy network devices with SDN nodes is neither simple nor straightforward. This has led to the idea of incremental and selective deployment of SDN nodes in an ISP network. Such a hybrid network gives us control over traffic flows that pass through the SDN nodes without requiring extensive changes to an existing ISP network. In this paper, we look at the problem of choosing an optimal set of egress routers to route inter-domain transit traffic in a hybrid SDN network such that the maximum link utilization of the egress links is minimized. We formulate the optimization problem, show that it is related to the makespan scheduling problem of unrelated parallel machines, and propose heuristics to solve it. We perform simulations to evaluate our heuristic on a real ISP topology and show that even with a small number of SDN nodes in the network, the maximum link utilization on the egress links can be lower than that of traditional HPR.
Weakly Supervised Top-down Image Segmentation (2006)

There has recently been significant interest in top-down image segmentation methods, which incorporate the recognition of visual concepts as an intermediate step of segmentation. This work addresses the problem of top-down segmentation with weak supervision. Under this framework, learning does not require a set of manually segmented examples for each concept of interest, but simply a weakly labeled training set. This is a training set where images are annotated with a set of keywords describing their contents, but visual concepts are not explicitly segmented and no correspondence is specified between keywords and image regions. We demonstrate, both analytically and empirically, that weakly supervised segmentation is feasible when certain conditions hold. We also propose a simple weakly supervised segmentation algorithm that extends state-of-theart bottom-up segmentation methods in the direction of perceptually meaningful segmentation1.
Concept of operations for knowledge discovery from Big Data across enterprise data warehouses (2013)

The success of data-driven business in government, science, and private industry is driving the need for seamless integration of intra and inter-enterprise data sources to extract knowledge nuggets in the form of correlations, trends, patterns and behaviors previously not discovered due to physical and logical separation of datasets. Today, as volume, velocity, variety and complexity of enterprise data keeps increasing, the next generation analysts are facing several challenges in the knowledge extraction process. Towards addressing these challenges, data-driven organizations that rely on the success of their analysts have to make investment decisions for sustainable data/information systems and knowledge discovery. Options that organizations are considering are newer storage/analysis architectures, better analysis machines, redesigned analysis algorithms, collaborative knowledge management tools, and query builders amongst many others. In this paper, we present a concept of operations for enabling knowledge discovery that data-driven organizations can leverage towards making their investment decisions. We base our recommendations on the experience gained from integrating multi-agency enterprise data warehouses at the Oak Ridge National Laboratory to design the foundation of future knowledge nurturing data-system architectures.