gebhart/patrepeval huggingface dataset:
Character-Based Pivot Translation for Under-Resourced Languages and Domains (2012)

In this paper we investigate the use of character-level translation models to support the translation from and to underresourced languages and textual domains via closely related pivot languages. Our experiments show that these low-level models can be successful even with tiny amounts of training data. We test the approach on movie subtitles for three language pairs and legal texts for another language pair in a domain adaptation task. Our pivot translations outperform the baselines by a large margin. 1
On Design of Low Cost Power Supply Noise Detection Sensor for Microprocessors (2012)

Recent trends in CMOS technology scaling have resulted in increased transistor density, higher clock speed and reduced cost per transistor. However technology scaling has also resulted in increased Power Supply Noise (PSN). Power supply noise can result in erroneous computation, reduced performance and lower reliability. Current PSN detectors require either golden supply voltage as reference or bulky analog to digital conversion circuits. This paper introduces a novel PSN detector for active power management in Microprocessors. The proposed detector makes use of the dynamic shift in Voltage Transfer Characteristics(VTC) of an inverter due to supply noise. Simulation results of the proposed PSN detector in 45-nm CMOS technology shows that the detector can detect overshoots or undershoots as small as 10 mV and 100 ps wide. Moreover, the detector works with 10 mV accuracy for a wide temperature range.
The Helsinki Heart Study: Central Findings and Clinical Implications (1991)

This paper describes the central findings and discusses the clinical implications of the Helsinki Heart Study. This was a controlled primary prevention trial to test the hypothesis that using gemfibrozil to lower the concentrations of serum low density lipoprotein (LDL) and very low density lipoprotein (VLDL) and to raise that of high density lipoprotein (HDL) protects subjects against coronary heart disease.
Improved Lignin Polyurethane Properties with Lewis Acid Treatment (2012)

Chemical modification strategies to improve the mechanical properties of lignin-based polyurethanes are presented. We hypothesized that treatment of lignin with Lewis acids would increase the concentration of hydroxyl groups available to react with diisocyanate monomers. Under the conditions used, hydrogen bromide-catalyzed modification resulted in a 28% increase in hydroxyl group content. Associated increases in hydrophilicity of solvent-cast thin films were also recorded as evidenced by decreases in water contact angle. Polyurethanes were then prepared by first preparing a prepolymer based on mixtures of toluene-2,4-diisocyanate (TDI) and unmodified or modified lignin, then polymerization was completed through addition of polyethylene glycol (PEG), resulting in mass ratios of TDI:lignin:PEG of 43:17:40 in the compositions investigated here. The mixture of TDI and unmodified lignin resulted in a lignin powder at the bottom of the liquid, suggesting it did not react directly with TDI. However, a homogeneous solution resulted when TDI and the hydrogen bromide-treated lignin were mixed, suggesting demethylation indeed increased reactivity and resulted in better integration of lignin into the urethane network. Significant improvements in mechanical properties of modified lignin polyurethanes were observed, with a 6.5-fold increase in modulus, which were attributed to better integration of the modified lignin into the covalent polymer network due to the higher concentration of hydroxyl groups. This research indicates that chemical modification strategies can lead to significant improvements in the properties of lignin-based polymeric materials using a higher fraction of an inexpensive lignin monomer from renewable resources and a lower fraction an expensive, petroleum-derived isocyanate monomer to achieve the required material properties.
Phase I randomized study of <scp>KHK</scp>4083, an anti‐<scp>OX</scp>40 monoclonal antibody, in patients with mild to moderate plaque psoriasis (2017)

KHK4083 administration as a single dose up to 10 mg/kg IV or 1.0 mg/kg SC was generally safe and well tolerated in patients with mild to moderate plaque psoriasis with no dose-limiting AEs.
Time domain reflectometry for soil properties (1999)

The primary objective of this study is to explore the potential use of electromagnetic characteristics of soils using the Time Domain Reflectometry (TDR) technique to identify physical properties of soils. Three fundamental studies in this exploration are the frequency-dependent electromagnetic properties of soils, the wave propagation in a TDR system, and the inverse analyses of TDR waveforms. The three-phase model for soils has been extended to a four-phase model so as to account for the interface effect and hence the soil fineness. The physical parameters of the four-phase model are related to the frequency-dependent dielectric permittivity of the soil through a semi-empirical volumetric mixing model. A spectral analysis method was developed to simulate wave propagation in the TDR system in a realistic way. Inverse analysis based on the material model and the wave propagation model was formulated using Bayesian statistics to calibrate the TDR system and to infer material properties from the measured TDR waveform. A TDR probe system was designed to measure the dielectric properties of soils in a compaction mold and in the field. An experimental program was carried out to make TDR measurements of 5 different soils with different water contents and densities. The result of the inverse analysis matched the TDR waveform very well and determined the dielectric spectrum of soils. With the ability to measure the dielectric spectrum of soils, the apparent dielectric constant at a particular frequency can be calculated. Results showed that the apparent dielectric constant at 1 GHz gave much better correlation with soil water content and density than the apparent dielectric constant obtained by traditional method.
Robust And Scalable Learning Of Complex Dataset Topologies Via Elpigraph (2018)

Large datasets represented by multidimensional data point clouds often possess non-trivial distributions with branching trajectories and excluded regions, with the recent single-cell transcriptomic studies of developing embryo being notable examples. Reducing the complexity and producing compact and interpretable representations of such data remains a challenging task. Most of the existing computational methods are based on exploring the local data point neighbourhood relations, a step that can perform poorly in the case of multidimensional and noisy data. Here we present ElPiGraph, a scalable and robust method for approximation of datasets with complex structures which does not require computing the complete data distance matrix or the data point neighbourhood graph. This method is able to withstand high levels of noise and is capable of approximating complex topologies via principal graph ensembles that can be combined into a consensus principal graph. ElPiGraph deals efficiently with large and complex datasets in various fields from biology, where it can be used to infer gene dynamics from single-cell RNA-Seq, to astronomy, where it can be used to explore complex structures in the distribution of galaxies.
Targeted <sup>64</sup>Cu‐labeled gold nanoparticles for dual imaging with positron emission tomography and optical imaging (2019)

Gold nanoparticles (AuNPs) have been used for many years in cancer treatment mainly for brachytherapy, but in the last 15 years, the focus has shifted to the development of ultrasmall target-specific AuNPs with homogeneous size and, ultimately, tailored shapes for use in various imaging modalities such as computed tomography (CT), Raman, or photoacoustic imaging. Here, we report on the development of tumor-specific AuNPs as diagnostic tools intended for the dual detection of prostate cancer via optical imaging (OI) and positron emission tomography (PET). The AuNPs were decorated with a near-infrared dye and NODAGA chelator for complexation with radiometals. Radiolabeling with <sup>64</sup> Cu was performed either indirect by complexation with NODAGA-AuNPs or by direct reduction of [<sup>64</sup> Cu]Cu(0) onto the surface of the AuNPs. Both methods yielded stable <sup>64</sup> Cu-AuNPs with radiochemical yield more than 95% confirmed by HPLC. <sup>64</sup> Cu-AuNPs were evaluated in a dual-imaging setting in vitro and in vivo and exhibited favorable diagnostic properties concerning detection, biodistribution, and clearance. Furthermore, the first therapeutic properties of the <sup>64</sup> Cu-AuNPs were evaluated in vitro concerning acute and long-term toxicity, indicating that these <sup>64</sup> Cu-AuNPs could be used in therapeutic concepts in the future.
Combination Therapy with Local Radiofrequency Ablation and Systemic Vaccine Enhances Antitumor Immunity and Mediates Local and Distal Tumor Regression (2013)

In vitro, sublethal hyperthermia of MC38-CEA(+) cells (a) increased cell-surface expression of CEA, Fas, and MHC class I molecules and (b) rendered tumor cells more susceptible to CTL-mediated lysis. In vivo, RFA induced (a) immunogenic modulation on the surface of tumor cells and (b) increased T-cell responses to CEA and additional TAAs. Combination therapy with RFA and vaccine in CEA-transgenic mice induced a synergistic increase in CD4(+) T-cell immune responses to CEA and eradicated both primary CEA(+) and distal CEA(-) s.c. tumors. Sequential administration of low-dose and high-dose RFA with vaccine decreased tumor recurrence compared to RFA alone. These studies suggest a potential clinical benefit in combining RFA with vaccine in cancer patients, and augment support for this novel translational paradigm.
Vector register allocation (1992)

The problem of allocating vector registers on supercomputers is addressed in the context of compiling vector languages. Two subproblems must be solved to achieve good vector register allocation. First, the vector operations in the source program must be subdivided into sections that fit the hardware of the target machine. Second, the locality of reference of the vector operations must be improved via aggressive program transformations. Solutions to both of these problems, based on the use of novel aspects of data dependence, are presented. The techniques described extend naturally to scalar machines by observing that a scalar register is simply a vector register of length one.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Polymorphisms of toll‐like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus (2003)

Human toll-like receptors (TLRs) participate in the innate response and signal the activation of adaptive immunity. Therefore, these TLRs may be important in autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We investigated, by using a polymerase chain reaction restriction-fragment length polymorphism method, the possible association between the polymorphisms of TLR2 (Arg677Trp and Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) genes with the susceptibility or severity of RA and SLE. Our study population consisted of 122 patients with SLE, 224 patients with RA, and a control group of 199 healthy individuals. The TLR2 polymorphisms were very rare in our population; no individual carrying the TLR2-Arg677Trp polymorphism was observed, whereas the TLR2-Arg753Gln polymorphism was present in only 1% of the total population. We found no statistically significant differences in the TLR4-Asp299Gly and the TLR4-Thr399Ile genotype or allele distribution between SLE patients, RA patients, and control individuals. Similarly, no association was found with any of the demographic and clinical parameters tested either in RA or in SLE patients. In conclusion, a case-control study was used to analyze, for the first time, the influence of TLR2 and TLR4 gene polymorphism on the predisposition and clinical characteristics of SLE and RA but provided no evidence for association of TLR2 or TLR4 gene polymorphism with either disease in the population under study.
In vitro re-endothelialization of detergent decellularized heart valves under simulated physiological dynamic conditions (2006)

The production of viable biological heart valves is of central interest in tissue engineering (TE). The aim of this study was to generate decellularized heart valves with an intact ultra-structure and to repopulate these with endothelial cells (EC) under simulated physiological conditions. Decellularization of ovine pulmonary valve conduits was performed under agitation in detergents followed by six wash cycles. Viability of EC cultures exposed to washing solution served to prove efficiency of washing. Resulting scaffolds were free of cells with preserved extracellular matrix. Biomechanical standard tension tests demonstrated comparable parameters to native tissue. Luminal surfaces of decellularized valvular grafts were seeded with ovine jugular vein EC in dynamic bioreactors. After rolling culture for 48 h, pulsatile medium circulation with a flow of 0.1 L/min was started. The flow was incremented 0.3 L/min/day up to 2.0 L/min (cycle rate: 60 beats/min), while pH, pO2, pCO2, lactate and glucose were maintained at constant physiological levels. After 7 days, a monolayer of cells covered the inner valve surface, which expressed vWF, indicating an endothelial origin. A complete endothelialization of detergent decellularized scaffold can be achieved under simulated physiological circulation conditions using a dynamic bioreactor system, which allows continuous control of the culture environment.
Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (<i>Tlr4</i>) (1999)

Bacterial lipopolysaccharide (LPS) provokes a vigorous, generalized proinflammatory state in the infected host. Genetic regulation of this response has been localized to the Lps locus on mouse chromosome 4, through study of the C3H/HeJ and C57BL/10ScCr inbred strains. Both C3H/HeJ and C57BL/10ScCr mice are homozygous for a mutant Lps allele (Lpsd/d) that confers hyporesponsiveness to LPS challenge, and therefore exhibit natural tolerance to its lethal effects. Genetic and physical mapping of 1,345 backcross progeny segregating this mutant phenotype confined Lps to a 0.9-cM interval spanning 1.7 Mb. Three transcription units were identified within the candidate interval, including Toll-like receptor 4 (Tlr4), part of a protein family with members that have been implicated in LPS-induced cell signaling. C3H/HeJ mice have a point mutation within the coding region of the Tlr4 gene, resulting in a nonconservative substitution of a highly conserved proline by histidine at codon 712, whereas C57BL/ 10ScCr mice exhibit a deletion of Tlr4. Identification of distinct mutations involving the same gene at the Lps locus in two different hyporesponsive inbred mouse strains strongly supports the hypothesis that altered Tlr4 function is responsible for endotoxin tolerance.
Adaptive deadlock- and livelock-free routing with all minimal paths in torus networks (1994)

This paper consists of two parts. In the first part, two new algorithms for deadlock- and livelock-free wormhole routing in the torus network are presented. The first algorithm, called Channels, is for the n-dimensional torus network. This technique is fully-adaptive minimal, that is, all paths with a minimal number of hops from source to destination are available for routing, and needs only five virtual channels per bidirectional link, the lowest channel requirement known in the literature for fully-adaptive minimal worm-hole routing. In addition, this result also yields the lowest buffer requirement known in the literature for packet-switched fully-adaptive minimal routing. The second algorithm, called 4-Classes, is for the bidimensional torus network. This technique is fully-adaptive minimal and requires only eight virtual channels per bidirectional link. Also, it allows for a highly parallel implementation of its associated routing node. In the second part of this paper, four worm-hole routing techniques for the two-dimensional torus are experimentally evaluated using a dynamic message injection model and different traffic patterns and message lengths.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ratiometric Fluorescence Sensor Based on a Pyrene Derivative and Quantification Detection of Heparin in Aqueous Solution and Serum (2011)

A ratiometric fluorescence sensor based on pyrene was designed for selective detection of heparin in HEPES (N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid) buffer and serum sample. Pyrene and long-chain alkanes were linked through bisquaternary functionality in the sensor which could interact with heparin via supramolecular assembly. A ratiometric fluorescent signal change of the sensor can be observed because of the specific monomer-excimer conversion of pyrene which is modulated by the supramolecular self-assembly of sensor and heparin. Upon addition of heparin, the excimer emission of the sensor at 489 nm is observed and the monomer emission intensity at 395 nm decreases concomitantly. Addition of heparin derivatives with very similar structure such as chondroitin 4-sulfate or hyaluronic acid to the same sensor solution only leads to very smaller changes in intensity ratios probably because of lower charge density and more distant spatial distribution of anions (or disadvantageous spatial orientation of anions) as compared to those of heparin. The novel sensor can effectively differentiate heparin from its derivatives with relatively low background interference and wide linear response in HEPES and serum. A linear calibration curve is obtained from 0 to 3.4 μM for heparin quantification in serum.
RECOGNITION: <i>Failure to comply with Recognition Recommendation</i> (1979)

Journal Article RECOGNITION: Failure to comply with Recognition Recommendation Get access P.L.D. P.L.D. Search for other works by this author on: Oxford Academic Google Scholar Industrial Law Journal, Volume 8, Issue 1, 1979, Pages 55–60, https://doi.org/10.1093/ilj/8.1.55 Published: 01 June 1979
Photochemical degradation of pyrazosulfuron-ethyl in aqueous solution (2013)

This report describes photochemical behaviors of pyrazosulfuron-ethyl in aqueous solution. The photodegradation of pyrazosulfuron-ethyl for the first time was investigated in aqueous solution at two different irradiation wavelengths and pH values ranging from 2.00 to 10.00. Results show that the rate of photodegradation was faster in acidic medium than that in basic medium, when pyrazosulfuron-ethyl was in neutral form. The half-lives of pyrazosulfuron-ethyl under ultra-violet light and simulated sunlight were found to be 27.17 and 153.33 min, respectively. The reactions followed first-order kinetics. The degradation pathways were proposed according to the identification results of photoproducts: carbon-sulfur and nitrogen-sulfur cleavages and photohydrolysis of the sulfonylurea bridge. It was concluded that photodegradation behaviors can occur within the sulfonylurea family, depending on the pH values of aqueous solution and the irradiation wavelengths.
Once bitten, twice shy: concern about gaining weight after smoking cessation and its association with seeking treatment (2014)

Among smokers who gained weight on a previous quit attempt, NTS had greater concern about gaining weight and less confidence in their ability to maintain their weight after quitting than treatment seekers. Clinicians can identify smokers for whom WGC may be a barrier to seeking treatment by asking if they gained weight on a previous quit attempt. These smokers should be assured that this issue will be addressed in treatment.
Fiber optic photoacoustic probe with ultrasonic tracking for guiding minimally invasive procedures (2015)

In a wide range of clinical procedures, accurate placement of medical devices such as needles and catheters is critical to optimize patient outcomes. Ultrasound imaging is often used to guide minimally invasive procedures, as it can provide real-time visualization of patient anatomy and medical devices. However, this modality can provide low image contrast for soft tissues, and poor visualization of medical devices that are steeply angled with respect to the incoming ultrasound beams. Photoacoustic sensors can provide information about the spatial distributions of tissue chromophores that could be valuable for guiding minimally invasive procedures. In this study, a system for guiding minimally invasive procedures using photoacoustic sensing was developed. This system included a miniature photoacoustic probe with three optical fibers: one with a bare end for photoacoustic excitation of tissue, a second for photoacoustic excitation of an optically absorbing coating at the distal end to transmit ultrasound, and a third with a Fabry-Pérot cavity at the distal end for receiving ultrasound. The position of the photoacoustic probe was determined with ultrasonic tracking, which involved transmitting pulses from a linear-array ultrasound imaging probe at the tissue surface, and receiving them with the fiber-optic ultrasound receiver in the photoacoustic probe. The axial resolution of photoacoustic sensing was better than 70 µm, and the tracking accuracy was better than 1 mm in both axial and lateral dimensions. By translating the photoacoustic probe, depth scans were obtained from different spatial positions, and two-dimensional images were reconstructed using a frequency-domain algorithm.
Identification and quantification of abundant species from pyrosequences of 16S rRNA by consensus alignment (2010)

16S rRNA gene profiling has recently been boosted by the development of pyrosequencing methods. A common analysis is to group pyrosequences into Operational Taxonomic Units (OTUs), such that reads in an OTU are likely sampled from the same species. However, species diversity estimated from error-prone 16S rRNA pyrosequences may be inflated because the reads sampled from the same 16S rRNA gene may appear different, and current OTU inference approaches typically involve time-consuming pairwise/multiple distance calculation and clustering. I propose a novel approach AbundantOTU based on a Consensus Alignment (CA) algorithm, which infers consensus sequences, each representing an OTU, taking advantage of the sequence redundancy for abundant species. Pyrosequencing reads can then be recruited to the consensus sequences to give quantitative information for the corresponding species. As tested on 16S rRNA pyrosequence datasets from mock communities with known species, AbundantOTU rapidly reported identified sequences of the source 16S rRNAs and the abundances of the corresponding species. AbundantOTU was also applied to 16S rRNA pyrosequence datasets derived from real microbial communities and the results are in general agreement with previous studies.
Ultralow biased widely continuously tunable fabry-Perot filter (2003)

Optical filters capable of single control parameter-based wide tuning are implemented and studied. The surface micromachined Fabry-Perot filter consists of two InP-air-gap distributed Bragg reflectors and shows a wavelength tuning of more than 140 nm using only a single voltage of up to 3.2 V at currents below 0.2 mA. The membrane-based filter is designed to block all wavelengths in the whole range of 1250-1800 nm apart from its transmission wavelength.