gebhart/patrepeval huggingface dataset:
In-line pseudoelliptic TE01d mode dielectric resonator filters (2012)

A new configuration for dielectric resonator filters with in-line structure and pseudoelliptic response is presented in this paper. The proposed concept is realized through the use of TE <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01δ</inf> single-mode resonators with different orientations cascaded along an evanescent mode waveguide. By exploiting a pair of orthogonal evanescent modes that can alternatively by-pass or excite the resonators, cross-coupling between nonadjacent pucks can be established and properly controlled. Pseudoelliptic filters can indeed be designed without using cumbersome cross-coupled architectures or reduced spurious performance dual-mode resonators. The experimental result of a 6 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> order filter with two transmission zeros in the lower stopband validates the proposed approach.
Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans (1993)

To identify the gene or genes associated with insulin resistance in Type II (non-insulin-dependent) diabetes mellitus, subtraction libraries were prepared from skeletal muscle of normal and diabetic humans and screened with subtracted probes. Only one clone out of 4000 was selectively overexpressed in Type II diabetic muscle as compared to muscle of non-diabetic or Type I diabetic individuals. This clone encoded a new 29-kilodalton member of the Ras-guanosine triphosphatase superfamily and was termed Rad (Ras associated with diabetes). Messenger ribonucleic acid of Rad was expressed primarily in skeletal and cardiac muscle and was increased an average of 8.6-fold in the muscle of Type II diabetics as compared to normal individuals.
Design and synthesis of 5,6‐dihydro‐4<i>H</i>‐1,3,4‐oxadiazines as potential octopaminergic insecticides (1993)

Abstract A novel class of insecticides, the dihydrooxadiazines, was proposed following the use of molecular modelling techniques. These compounds represent conformationally restricted analogues of octopamine. Eight dihydrooxadiazines were synthesized and evaluated for useful insecticidal properties. Several of these compounds demonstrated activity against rice planthoppers, mite eggs, and tobacco budworm eggs.
miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification (2016)

Understanding the mechanisms of early cardiac fate determination may lead to better approaches in promoting heart regeneration. We used a mesoderm posterior 1 (Mesp1)-Cre/Rosa26-EYFP reporter system to identify microRNAs (miRNAs) enriched in early cardiac progenitor cells. Most of these miRNA genes bear MESP1-binding sites and active histone signatures. In a calcium transient-based screening assay, we identified miRNAs that may promote the cardiomyocyte program. An X-chromosome miRNA cluster, miR-322/-503, is the most enriched in the Mesp1 lineage and is the most potent in the screening assay. It is specifically expressed in the looping heart. Ectopic miR-322/-503 mimicking the endogenous temporal patterns specifically drives a cardiomyocyte program while inhibiting neural lineages, likely by targeting the RNA-binding protein CUG-binding protein Elav-like family member 1 (Celf1). Thus, early miRNAs in lineage-committed cells may play powerful roles in cell-fate determination by cross-suppressing other lineages. miRNAs identified in this study, especially miR-322/-503, are potent regulators of early cardiac fate.
Optical spectroscopy vs. the surgical suite [cancer detection] (1996)

A novel non-invasive technique for detecting cancer and precancer offers a viable adjunct to biopsies. Here, we summarize the principles of optical spectroscopy and present some of the highlights obtained with the successful application of fluorescence and Raman spectroscopy for cancer and precancer detection.
On trigger detection against reactive Jamming Attacks: A clique-independent set based approach (2009)

Among existing countermeasures against Reactive Jamming Attacks in Wireless Sensor Networks, the detection of trigger nodes whose transmissions invoke the jammer nodes has been proposed and developed as an efficient jamming-resistent routing scheme in unreliable WSN environments. Sequential group testing techniques were adopted in our previous work to alleviate the overhead of trigger detection in terms of time and communication complexity. In this paper, we further improve the detection procedure by leveraging the classic models of randomized non-adaptive group testing and clique-independent set, which dramatically decreases the time complexity compared to our previous solution.
Identification of a potent peptide antagonist to an active laminin-1 sequence that blocks angiogenesis and tumor growth. (2003)

The extracellular matrix plays an important role in many physiological processes. We have identified >20 angiogenic sites in the extracellular matrix protein laminin-1. The most potent sites are A13 (RQVFQVAYIIIKA) and C16 (KAFDITYVRLKF), which are present in homologous NH(2)-terminal domains of the alpha 1 and gamma 1 chains, respectively. We reported recently that a scrambled C16 sequence, C16S (DFKLFAVTIKYR), acts as an antagonist to both peptides. Here, we have identified a stronger antiangiogenic peptide, C16Y (C16S with a T to Y substitution), with potent activity in several biological assays including tumor growth. C16Y is more potent in promoting endothelial cell attachment and inhibiting attachment to laminin-1 than either C16 or C16Y. Disruption of tube formation by C16Y is also observed at concentrations at least five times lower than C16S. The minimal active sequence was found to be DFKLFAVY. C16Y is more potent in blocking C16-induced chick chorioallantoic membrane angiogenesis than C16S. Tumor growth studies on the chick chorioallantoic membrane showed that C16Y reduces breast cancer cell growth without affecting cell proliferation. This result suggests that angiogenesis is being inhibited by the peptide. In vivo animal studies demonstrated that C16Y treatment significantly reduced tumor growth and decreased tumor vessel number, as compared with controls, additionally suggesting that angiogenesis was affected. These results indicate that we have identified a more potent antiangiogenesis inhibitor peptide that may be used as a therapeutic to treat cancer.
Differential distribution and defence involvement of antimicrobial peptides in mussel (2000)

In previous papers, we characterised 3 types of 4-kDa, cysteine-rich, cationic antimicrobial peptides: MGDs (for Mytilus galloprovincialis defensins), mytilins and myticins, which are abundant in the mussel hemocytes. In the present work, we revealed a differential distribution of the cells expressing the different genes. In addition, using confocal and electron microscopy, we confirmed that defensins and mytilins were partially located in different sub-types of circulating hemocytes although the peptides can be located in the same cell, and even in the same granule. We also demonstrated that mytilins exert their microbicidal effect within the cells through the process of phagosome-mytilin granule fusion leading to the co-location of ingested bacteria and mytilins.
Measurement of Short Telomere Load in Individual Cells (2019)

Increasing evidence demonstrates that shortest more than mean telomere length predicts telomere dysfunction and genomic instability in association with a number of conditions, including cell senescence, aging and tumorigenesis. We developed Universal Single Cell Single Telomere Length Analysis (USC-STELA), based on a PCR-amplification and southern blotting, to measure short telomeres in individual cells. The mean short telomere length measured in individual cells by USC-STELA correlates with that from bulk cells, measured by Universal STELA (U-STELA). The validation and reproducibility of USC-STELA was confirmed using different cell types with known telomere lengths, as well as by using paired sister-cells from human embryos and cultured cells. Interestingly, individual cells known to elongate telomeres via alternative lengthening of telomeres (ALT) have more short telomeres, yet longer mean telomere length than control cells. Moreover, individual senescent fibroblasts carry more short telomeres compared to human embryonic stem cells (hESCs), consistent with the notion that short telomeres contribute to cellular senescence. Additionally, we found a greater load of short telomeres in polar bodies than in matching oocytes, providing further insights into the accelerated polar body DNA degradation following extrusion from the oocyte. USC-STELA provides a new method to study telomere dysfunction in individual cells, with potential to improve our understanding of the role of telomere dynamics in cancer, developmental biology and reproductive medicine.
Multifaceted α-Enaminone: Adaptable Building Block for Synthesis of Heterocyclic Scaffolds Through Conceptually Distinct 1,2-, 1,3-, 1,4-, and C–O Bond Forming Annulations (2017)

The new reactivity of α,β-unsaturated enaminones driven by their "dual electronic attitude" is reported. We introduce unexplored, α-enaminone synthones and reveal the unusual functionalities of these building blocks. The feasibility of this new concept is demonstrated in the direct functionalization of enaminone precursors, such as alkylation; 1,2- 1,3-, or 1,4-addition; and C-O bond formation. The general and potential applicability is presented through the collective synthesis of several important classes of heterocycles via controlled cyclizations of easily accessible common precursors. The rapid composition of novel key α-enaminone synthones yields an assembly of oxazines, azaspirones, quinolinones, and quinolinols in a regio- and chemoselective fashion.
Measurement of dna adducts using surface‐enhanced Raman spectroscopy (1993)

Hazardous pollutants emitted from energy-related technologies, chemical industries, or waste materials are of increasing public concern because of their potential adverse health effects. Many pollutants have chemical groups of toxicological importance that can be characterized and detected by Raman spectroscopy. Raman spectroscopy, however, has not been widely used in trace organic detection, even though the information contained in a Raman spectrum is valuable for chemical identification. One limitation of conventional Raman spectroscopy is its low sensitivity, which often necessitates the use of powerful and costly laser sources for sample excitation. Raman spectroscopists have recently been able to analyze dilute biological samples as a result of enhancements in the Raman scattering cross section by factors up to 10(10) when a compound is adsorbed on or near a special electron-conducting surface. These spectacular enhancement factors of the normally weak Raman scattering process help overcome the low sensitivity of Raman spectroscopy through a combination of electromagnetic and chemical interactions between the analyte molecule and the surface. The technique associated with this phenomenon is known as surface-enhanced Raman scattering spectroscopy (SERS). The special conductive surface responsible for the scattering enhancement is referred to as a SERS substrate. For the past few years we have developed the SERS technique, using practical SERS-active substrate materials based on silver-coated microspheres deposited on glass. A wide variety of biomarkers have been investigated, including benzo[a]pyrene, dibenz[a,h]anthracene epoxides, 1,N9-ethenoadenine, 3,N4-ethenocytosine, and other substances. These biomarkers were measured at nanogram and subnanogram levels. The experimental results are of great analytical interest, since these chemicals are difficult to detect by other techniques, such as luminescence spectroscopy, because of the weak luminescence quantum yields of these DNA adducts. In this paper the potential usefulness of the SERS technique for assessing environmental and health effects from human exposure to toxic pollutants is demonstrated.
THE EFFECT ON THE HUMAN UTERUS OF TWO NEWLY DEVELOPED COMPETITIVE INHIBITORS OF OXYTOCIN AND VASOPRESSIN (1985)

In order to develop inhibitors of vasopressin (VP) and oxytocin (OXY) action on uterine activity, 1-deaminated vasotocin derivatives with modifications at positions 2, 4 and 8 were developed. Two of the most effective analogues in the rat, 1-deamino-2-D-Tyr(OEt)-4-Val-8-Orn-vasotocin (dE-VVT) and 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-vasotocin (dE-TVT) were now tested on human nonpregnant myometrium obtained at hysterectomy in fertile age and on pregnant myometrial tissue obtained at elective cesarean section. The effect was compared with that of a previously synthesized analogue 1-deamino-Tyr(OEt)-oxytocin (dE-OXY) which has already been tested in nonpregnant and pregnant women in vivo. Both of the new analogues competitively inhibited the action of the posterior pituitary hormones. On the nonpregnant uterus dE-VVT was about five times and dE-TVT almost twenty-five times more potent than dE-OXY in inhibiting the effects of VP. On pregnant myometrium, dE-TVT inhibited oxytocin action about as effectively as a five-fold stronger concentration of dE-OXY, and dE-VVT slightly less. A moderate agonistic effect of dE-OXY on pregnant myometrium was found, whereas it was minimal with dE-VVT and not detectable at all with dE-TVT. It appears that these two analogues, particularly dE-TVT, would be interesting for clinical testing both in dysmenorrhea, where increased VP secretion could be of etiological importance, and in premature labor where an increased myometrial concentration of OXY receptors has been demonstrated.
A Mutation in the β3-Adrenergic Receptor Gene Is Associated with Obesity and Hyperinsulinemia in Japanese Subjects (1995)

The Trp 64 Arg mutation in the beta 3-adrenergic receptor (beta 3AR) gene was investigated in 350 Japanese subjects. This mutation was not associated with non-insulin-dependent diabetes mellitus (NIDDM). In 191 subjects without NIDDM, body mass index (BMI) was significantly higher in subjects homozygous for this mutation than in those homozygous for the normal allele (24.7 +/- 1.4 vs 22.1 +/- 0.2 kg/m2, p = 0.009). Moreover, the frequency of the mutant allele in obese subjects (BMI > 26.4) was significantly higher than that in non-obese subjects (BMI < 22) (0.37 vs 0.15, p = 0.009). The presence of this mutation was also accompanied by significantly higher fasting (p = 0.000) and 2 hrs (p = 0.018) serum insulin levels during an oral glucose tolerance test. The beta 3AR may be one of the loci contributing to obesity and hyperinsulinemia/insulin resistance in Japanese subjects.
piggyBac is an effective tool for functional analysis of the Plasmodium falciparumgenome (2009)

Our results clearly demonstrate that piggyBac is a novel, indispensable tool for forward functional genomics in P. falciparum that will help better understand parasite biology and accelerate drug and vaccine development.
Trends in stimulated Brillouin scattering and optical phase conjugation (2008)

Abstract An overview on current trends in stimulated Brillouin scattering and optical phase conjugation is given. This report is based on the results of the “Second International Workshop on stimulated Brillouin scattering and phase conjugation” held in Potsdam/Germany in September 2007. The properties of stimulated Brillouin scattering are presented for the compensation of phase distortions in combination with novel laser technology like ceramics materials but also for e.g., phase stabilization, beam combination, and slow light. Photorefractive nonlinear mirrors and resonant refractive index gratings are addressed as phase conjugating mirrors in addition.
A Tale of Two DRAGGNs: A Hybrid Approach for Interpreting\n Action-Oriented and Goal-Oriented Instructions (2017)

Robots operating alongside humans in diverse, stochastic environments must be\nable to accurately interpret natural language commands. These instructions\noften fall into one of two categories: those that specify a goal condition or\ntarget state, and those that specify explicit actions, or how to perform a\ngiven task. Recent approaches have used reward functions as a semantic\nrepresentation of goal-based commands, which allows for the use of a\nstate-of-the-art planner to find a policy for the given task. However, these\nreward functions cannot be directly used to represent action-oriented commands.\nWe introduce a new hybrid approach, the Deep Recurrent Action-Goal Grounding\nNetwork (DRAGGN), for task grounding and execution that handles natural\nlanguage from either category as input, and generalizes to unseen environments.\nOur robot-simulation results demonstrate that a system successfully\ninterpreting both goal-oriented and action-oriented task specifications brings\nus closer to robust natural language understanding for human-robot interaction.\n
High-efficiency GaAs power MESFETs prepared by ion implantation (1982)

GaAs power MESFETs have been fabricated using ion implantation to form channel layers. A 1 μm gate length by 2400 μm gate width device has demonstrated an output power of 1.63 W with 6.9 dB associated gain, 35% power-added efficiency and 9.7 dB linear gain at 10 GHz. The transconductance of this device is 280 mS, which corresponds to 117 mS/mm. This result demonstrates that excellent GaAs power MESFETs can be made by ion implantation, and is comparable to average results demonstrated by devices made by AsCl3 vapour phase epitaxy.
Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B–ESAT6 fusion protein (2009)

A recombinant Salmonella enterica serovar Typhimurium (S. Typhimurium) vaccine strain was constructed that stably expressed the Mycobacterium tuberculosis fusion antigen Ag85B-ESAT6 from the chromosome. Live oral vaccination of mice with the Salmonella/Ag85B-ESAT6 strain generated a potent anti-Ag85B-ESAT6 T(H)1 response with high antibody titres with a IgG2a-bias and significant IFN-gamma production lasting over a 120-day period. When mice primed with the Salmonella/Ag85B-ESAT6 vaccine were mucosally boosted with the Ag85B-ESAT6 antigen and adjuvant the IFN-gamma responses increased markedly. To determine the protective efficacy of this vaccine strain, guinea pigs were immunised and followed for a 30-week period after aerosol challenge with M. tuberculosis. The heterologous prime-boost strategy of live Salmonella vaccine followed by a systemic boost of antigen and adjuvant reduced the levels of M. tuberculosis bacteria in the lungs and spleen to the same extent as BCG. Additionally, this vaccination regimen was observed to be statistically equivalent in terms of protection to immunisation with BCG. Thus, live oral priming with the recombinant Salmonella/Ag85B-ESAT6 and boosting with Ag85B-ESAT6 plus the adjuvant LTK63 represents an effective mucosal vaccination regimen.
High-power short-wavelength quantum cascade lasers (2005)

We describe the design and implementation of a broad-gain and low-threshold (Jth = 860 A/cm<sup>2</sup> at 8 K) quantum-cascade laser based on strain-compensated In<sub>0.73</sub>Ga<sub>0.27</sub>As-AlAs on InP. Laser emission between 3.7 and 4.2 um is achieved because of the very large Gamma-valley conduction band discontinuity with narrow quantum wells, allowing large intersubband energy differences. Furthermore, the design inhibits carrier loss from the upper lasing state into the continuum even at elevated operating temperatures, resulting in room-temperature operation. Laser operation in pulsed mode is achieved up to a temperature of 330 K with maximum single-facet output peak powers of 6 W at 8 K and 240 mW at 296 K. The temperature coefficient T0 is 119K. The 30-period structure exhibits an external differential efficiency of 13 (40% per period) at low temperatures and a maximum wall-plug efficiency of 24%. The lasing transition takes place from several upper states to several lower states, resulting in a relatively broad (300 cm<sup>-1</sup>) gain spectrum and could allow the design to be used in external tuning configurations.
Processing and Friction Properties of Intermetallic-Bonded Diamond Ceramtc Composites (2008)

The innovative use of intermetallics to bond diamonds and ceramics has led to a potentially new friction material. Intermetallics containing Ni and Al have the potential to make a hard, tough bonding phase for ceramic and diamond particulates that increases in strength with temperature. This is the first reported successful introduction of diamonds within a metallic matrix that has been sintered to temperatures exceeding 140O°C without the deterioration and/or decomposition of the diamonds. Intermetallic–bonded diamond (IBD) composites containing 30–60 vol% intermetallic and 70–30 vol% ceramic and diamond were produced by sintering in Ar, vacuum sintering, and hot pressing. DSC was used to identify critical reaction temperatures. Following densification samples were then subjected to friction testing and the friction surface analyzed. Coefficient of friction values of 0.35 to 0.50 were obtained for selected formulations. SEM results confirmed that the diamonds remained at the wear interface and were not pulled out by testing. The processes employed and the results will be presented and discussed.
Giant Terahertz field enhancement with plasmonic antennas (2009)

In this paper, the authors present a study of the dependence of the field enhancement on geometrical parameters of the antennas and the optimization of these parameters to attain the largest possible enhancement. Intensity enhancements up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> times the incident intensity are possible with semiconductor THz antennas. In particular, the THz scattering and near field enhancement by rectangular and bow-tie semiconductor antennas have been calculated using the rigorous two-dimensional (2D) Green integral formulation of the electromagnetic wave scattering.
Methods for connecting dissimilar three-dimensional finite element meshes (2000)

Two methods are presented for connecting dissimilar three-dimensional finite element meshes. The first method combines the concept of master and slave surfaces with the uniform strain approach for finite elements. By modifying the boundaries of elements on a slave surface, corrections are made to element formulations such that first-order patch tests are passed. The second method is based entirely on constraint equations, but only passes a weaker form of the patch test for non-planar surfaces. Both methods can be used to connect meshes with different element types. In addition, master and slave surfaces can be designated independently of relative mesh resolutions. Example problems in three-dimensional linear elasticity are presented. Published in 2000 by John Wiley & Sons, Ltd.
Orthonormal polynomials for hexagonal pupils (2006)

The problem of determining the orthonormal polynomials for hexagonal pupils by the Gram-Schmidt orthogonalization of Zernike circle polynomials is revisited, and closed-form expressions for the hexagonal polynomials are given. We show how the orthonormal coefficients are related to the corresponding Zernike coefficients for a hexagonal pupil and emphasize that it is the former that should be used for any quantitative wavefront analysis for such a pupil.