gebhart/patrepeval huggingface dataset:
Influences of Frailty Syndrome on Open-Loop and Closed-Loop Postural Control Strategy (2014)

This study suggested an innovative method to differentiate between frailty status using sensory dependency characteristics of postural control. RESULTS suggest that postural muscle deconditioning may compromise balance in frail elders, leading to dependency on somatosensory feedback to compensate for errors and stabilize the system.
Optical trapping for complex fluid microfluidics (2004)

Many proposed applications of microfluidics involve the manipulation of complex fluid mixtures such as blood or bacterial suspensions. To sort and handle the constituent particles within these suspensions, we have developed a miniaturized automated cell sorter using optical traps. This microfluidic cell sorter offers the potential to perform chip-top microbiology more rapidly and with less associated hardware and preparation time than other techniques currently available. To realize the potential of this technology in practical clinical and consumer lab-on-a-chip devices however, microscale control of not only particulates but also the fluid phase must be achieved. To address this, we have developed a mechanical fluid control scheme that integrates well with our optical separations approach. We demonstrate here a combined technique, one that employs both mechanical actuation and optical trapping for the precise control of complex suspensions. This approach enables both cell and particle separations as well as the subsequent fluid control required for the completion of complex analyses.
Yima: a second-generation continuous media server (2002)

Continuous media data requires a streaming architecture that can manage real-time delivery constraints and address the large size of CM objects. Although commercial systems ordinarily use proprietary technology and algorithms, making it difficult to compare their products with research prototypes, the authors have designed and developed Yima, a second-generation CM server that demonstrates several advanced concepts. Although this system has not yet achieved the refinement of commercial solutions, it is operational and incorporates lessons learned from first-generation research prototypes, including complete distribution, efficient online scalability, and synchronization of several media streams within a single frame. The paper discusses the multinode server architecture.
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease (2020)

Soluble oligomers of aggregated tau accompany the accumulation of insoluble amyloid fibrils, a histological hallmark of Alzheimer disease (AD) and two dozen related neurodegenerative diseases. Both oligomers and fibrils seed the spread of Tau pathology, and by virtue of their low molecular weight and relative solubility, oligomers may be particularly pernicious seeds. Here, we report the formation of <i>in vitro</i> tau oligomers formed by an ionic liquid (IL15). Using IL15-induced recombinant tau oligomers and a dot blot assay, we discovered a mAb (M204) that binds oligomeric tau, but not tau monomers or fibrils. M204 and an engineered single-chain variable fragment (scFv) inhibited seeding by IL15-induced tau oligomers and pathological extracts from donors with AD and chronic traumatic encephalopathy. This finding suggests that M204-scFv targets pathological structures that are formed by tau in neurodegenerative diseases. We found that M204-scFv itself partitions into oligomeric forms that inhibit seeding differently, and crystal structures of the M204-scFv monomer, dimer, and trimer revealed conformational differences that explain differences among these forms in binding and inhibition. The efficiency of M204-scFv antibodies to inhibit the seeding by brain tissue extracts from different donors with tauopathies varied among individuals, indicating the possible existence of distinct amyloid polymorphs. We propose that by binding to oligomers, which are hypothesized to be the earliest seeding-competent species, M204-scFv may have potential as an early-stage diagnostic for AD and tauopathies, and also could guide the development of promising therapeutic antibodies.
Generation and use of statistical timing macro-models considering slew and load variability (2016)

Timing macro-modeling captures the timing characteristics of a circuit in a compact form for use in a hierarchical timing environment. At the same time, statistical timing provides coverage of the impact from variability sources with the goal of enabling higher chip yield. This paper presents an efficient and accurate method for generation and use of statistical timing macro-models. Results in a commercial timing analysis framework with non-separable statistical timing models demonstrate average performance improvements of 10× when using the model with less than 0.3 picosecond average and 5.5 picosecond maximum accuracy loss, respectively.
9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic β Cell Protection and Replication (2008)

Recently, the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) emerged as a regulator of pancreatic beta cell growth and survival. On the basis of the previous observation that GSK-3 inhibitors like 1-azakenpaullone promote beta cell protection and replication, paullone derivatives were synthesized including 1-aza-, 2-aza-, and 12-oxapaullone scaffolds. In enzymatic assays distinct 1-azapaullones were found to exhibit selective GSK-3 inhibitory activity. Within the series of 1-azapaullones, three derivatives stimulated INS-1E beta cell replication and protected INS-1E cells against glucolipotoxicity induced cell death. Cazpaullone (9-cyano-1-azapaullone), the most active compound in the protection assays, also stimulated the replication of primary beta cells in isolated rat islets. Furthermore, cazpaullone showed a pronounced transient stimulation of the mRNA expression of the beta cell transcription factor Pax4, an important regulator of beta cell development and growth. These features distinguish cazpaullone as a unique starting point for the development of beta cell regenerative agents which might be useful in the treatment of diabetes.
Growth Retardation and Tumour Inhibition by BRCA1 (1996)

Holt, Jeffrey T.; Thompson, Marilyn E.; Szabo, Csilla; Robinson-Benion, Cheryl; Arteaga, Carlos L.; King, Mary-Claire; Jensen, Roy A. Author Information
Improved Feedback for 802.16e MIMO Precoding (2004)

In this contribution, a compact feedback scheme is proposed. The feedback scheme can reduce the overhead in the draft standard by a factor of more than 3 at the cost of additional computations. The feedback overhead is 1-4 CQICH channels per 36 subcarriers for up to 8x4 MIMO configuration. The overhead reduction is achieved by four means. First, the receiver feeds back transmit beamforming vectors instead of the channel matrix. This reduces the overhead by a factor of more than 1.6 on average. Secondly, the elements of each beamforming vector are jointly quantized by vector quantization using small vector codebooks. The vector quantization reduces the overhead by a factor of two compared to the scalar quantization in current draft. Thirdly, the frequency coherence is exploited. Frequency domain downsampling and interpolation are employed. The beamforming matrix feedback is conducted for every 36 subcarriers. Finally, the scheme feeds back the beamforming vectors only for the active spatial channels. This provides a significant overhead reduction in the case of spatial channel puncture, where the spatial channel corresponding to the weakest eigenmode is usually punctured.
Viscosity Reduction And Upgrading Of Athabasca Oilsands Bitumen By Natural Zeolite Cracking (2010)

Oilsands bitumen is an extremely important source of energy for North America. However, due to the presence of large molecules such as asphaltenes, the density and viscosity of the bitumen recovered from these sands are much higher than those of conventional crude oil. As a result the extracted bitumen has to be diluted with expensive solvents, or thermochemically upgraded in large, capital-intensive conventional upgrading facilities prior to pipeline transport. This study demonstrates that globally abundant natural zeolites such as clinoptilolite from Saint Clouds, New Mexico and Ca-chabazite from Bowie, Arizona can be used as very effective reagents for cracking and visbreaking of oilsands bitumen. Natural zeolite cracked oilsands bitumen products are highly recoverable (up to ~ 83%) using light hydrocarbons such as pentane, which indicates substantial conversion of heavier fractions to lighter components. The resultant liquid products are much less viscous, and have lighter product distribution compared to those produced from pure thermal treatment. These natural minerals impart similar effect on industrially extracted Athabasca bitumen.
Implementing e-Transactions with asynchronous replication (2002)

An e-Transaction is one that executes exactly-once despite failures. This paper describes a distributed protocol that implements the abstraction of e-Transaction in three-tier architectures. Three-tier architectures are typically Internet-oriented architectures, where the end-user interacts with front-end clients (e.g., browsers) that invoke middle-tier application servers (e.g., web servers) to access back-end databases. We implement the e-Transaction abstraction using an asynchronous replication scheme that preserves the three-tier nature of the architecture and introduces a very acceptable overhead with respect to unreliable solutions.
Extended sequence preferences for oligodeoxyribonucleotide activity (2006)

Synthetic type B phosphorothioate oligodeoxyribonucleotides (ODN) activate mouse B cells via Toll-like receptor 9 (TLR9). Starting with closely related 15-mer prototype ODN, the sequence requirements for stimulatory (ST-) and inhibitory (IN-) activity were contrasted, by measuring apoptosis protection, G(1) entry and interleukin-6 secretion. ST-ODN and IN-ODN differ in that (1) ST-ODN require a 5' T, (2) the central CG is obligatory, (3) CG must be flanked 3' specifically by TT at the position where IN-ODN have GG, and (4) IN-ODN tolerate truncation of the 3' end better than ST-ODN. Features shared by ST-ODN and IN-ODN include (1) requiring CC adjacent to the 5' end, and (2) avoiding CC immediately 5' to the CG. This pattern is used to create a model of how ST-ODN binding might function to aggregate TLR9 so as to initiate the signal, and how the 5' ends of ST-ODN and IN-ODN compete for binding. Further justification for considering TLR9 to be the ODN receptor was provided by a demonstration that in HEK293 cells transfected with TLR9, the potency of a panel of ODN for activating NF-kappaB roughly parallels that seen in the biological assays in mouse B cells.
Enhanced Stability and Reduced Emissions in an Elliptic Swirl-Stabilized Burner (2008)

Unstable thermoacoustic modes were studied and controlled passively by changing the geometry of a swirl-stabilized burner to an elliptic shape. The elliptic burner modified the mixing of the fuel and the air, the fresh fuel/air mixture, and the hot combustion products. The flow dynamics induced by the noncircular burner affected the flame stabilization at the central recirculation zone and at the sudden expansion. In addition to the enhanced mixing, the elliptic burner achieved lower emissions while stabilizing the combustion by reducing the coherence of the large-scale vortices at the burner's exit. The combustion tests were performed in a range of normalized equivalence ratios from near lean blowout to 1.2 times the nominal equivalence ratio, at two different power levels. In addition, power variations from 0.54 to 1.15 of the nominal power at nominal equivalence ratios were performed. Pressure and heat-release fluctuations were measured and analyzed for all operating conditions. The elliptic burner showed reductions of more than two orders of magnitude (-24 dB) in pressure and heat-release oscillations in the entire range of equivalence ratios measured. The structures of the different instability modes (axisymmetric at St = 0.6 and helical at 1.7 and 7.1) were studied with an intensified charge-coupled-device camera filtered to monitor OH chemiluminescence using phased-locked visualization. The axisymmetric mode showed substantially reduced variability in heat-release rate during the cycle of instability, compared with the axisymmetric baseline burner. This behavior resulted in a reduced level of instability, as evidenced from the spectral analysis of the pressure oscillations. NO x and CO emissions were considerably reduced: NO x by up to four times and CO by a factor of 2-3. Unburned-hydrocarbon emissions were significantly reduced for normalized equivalence ratios below 0.9, indicating an extension of the lean-blowout limit. The strong suppression of thermoacoustic instability and large reductions of emissions persisted in the entire range of power output tested.
Optical system for double-biprism electron holography (2005)

A novel system of electron interferometry and holography using two electron biprisms has been developed. The first biprism is installed in the image plane of the objective lens and the second one is set behind the first magnifying lens, inside the shadow area of the first biprism. The system can independently control two important parameters for interferograms and holograms, the fringe spacing and interference width. Thus, it gives us more flexibility on performing electron interferometry and holography. The good performance of the system was demonstrated using a 1MV field-emission electron microscope. We introduce a variety of optical set-ups for the system and explain the advantages of each set-up in detail, with experimental results.
A Novel Modular Tonometry-Based Device to Measure Pulse Pressure Waveforms in Radial Artery (2018)

The paper presents the development of a new device for measuring continuous pulse pressure waveforms (PPW) from the radial artery via applanation tonometry. The development focuses on improved accuracy, open and affordable design using off-the-shelf components, and greater user control in setting operational and calibration parameters to address user variability. The device design parameters are optimized through a tissue device interaction study based on a computational model. The design incorporates modular components and includes a sensor module for arterial flattening and pressure pick-up, a differential screw mechanism and a related algorithm for controlled stepwise motion and data collection during flattening, and a brace for wrist-flexion adjustment. Maximum pulse amplitude (PA) was used as an indicator of the optimum level of arterial flattening for recording the PPW. The PPW was observed to distort due to changes in parameters like gel-head placement, hold-down pressure (HDP), and wrist extension. The pressure waveforms collected using the device were validated using limited data against established products and showed good correlation within ±1.96 standard deviation of the mean difference in a Bland–Altman plot. This paper thus details the development of a simple and validated mechanical design to measure PPW using arterial tonometry.
Scalable Coding of Depth Maps With R-D Optimized Embedding (2013)

Recent work on depth map compression has revealed the importance of incorporating a description of discontinuity boundary geometry into the compression scheme. We propose a novel compression strategy for depth maps that incorporates geometry information while achieving the goals of scalability and embedded representation. Our scheme involves two separate image pyramid structures, one for breakpoints and the other for sub-band samples produced by a breakpoint-adaptive transform. Breakpoints capture geometric attributes, and are amenable to scalable coding. We develop a rate-distortion optimization framework for determining the presence and precision of breakpoints in the pyramid representation. We employ a variation of the EBCOT scheme to produce embedded bit-streams for both the breakpoint and sub-band data. Compared to JPEG 2000, our proposed scheme enables the same the scalability features while achieving substantially improved rate-distortion performance at the higher bit-rate range and comparable performance at the lower rates.
Electro-optical THz phase control (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Sydlo, M. Feiginov, T. Goebel, D. Schoenherr, P. Meissner, and H. L. Hartnagel, "Electro-optical THz phase control," in CLEO:2011 - Laser Applications to Photonic Applications, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper CMFF5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Inspection sensitivity improvement by wafer sort failure sites matching algorithm — Chimin Chen (2015)

Micro-crack of ILD oxide in peripheral area leads to wafer sort leakage failure issue. However, high nuisance rate in peripheral area inspection cannot monitor it effectively. This paper addresses a new methodology to improve the inspection sensitivity by transferring the wafer sort specific failure sites into GDS coordinates on design layout. These failure sites are the patterns of interest (POIs) which induced micro-crack easily. Further patterns grouping and searching will find out the similar patterns in whole chip, therefore, we can transfer these POIs into thousands to millions of care areas to do the extreme high sensitivity inspection. As compared to previous full scan area, the care area reduction with small POIs clips is 1/10 of original full scan area. High sensitivity inspection can monitor critical processes effectively, and improve the turnaround time (TAT) of product development efficiently.
High-voltage rectifier and voltage doubler in conventional 0.18&#x03BC;m CMOS process (2010)

A high-voltage full-wave rectifier and a high-voltage voltage doubler for converting an induced voltage on a coil to a DC voltage were demonstrated in a conventional 0.18μm CMOS process using standard 3.3V I/O devices. High-voltage operations were achieved by stacking a number of transistors with their gate voltages controlled by the induced voltages. For a 300kHz, 14.2V peak-to-peak induced voltage, the voltage doubler achieved an efficiency of 92.5% for an output voltage of 13.7V with an output power of 2.9mW.
Validation of a Novel Catheter Guiding Method for the Ablative Therapy of Ventricular Tachycardia in a Phantom Model (2008)

Accurate guidance of an ablation catheter is critical in the RF ablation (RFA) of ventricular tachycardia (VT). With current technologies, it is challenging to rapidly and accurately localize the site of origin of an arrhythmia, often restricting treatment to patients with hemodynamically stable arrhythmias. We investigated the effectiveness of a new guidance method, the inverse solution guidance algorithm (ISGA), which is based on a single-equivalent dipole representation of cardiac electrical activity and is suitable for patients with hemodynamically unstable VT. Imaging was performed in homogeneous and inhomogeneous saline-filled torso phantoms in which a catheter tip was guided toward a stationary electrical dipole source over distances of more than 5 cm. Using ISGA, the moving catheter tip was guided to within 0.61 +/-0.43 and 0.55 +/-0.39 mm of the stationary source in the homogeneous and inhomogeneous phantoms, respectively. This accuracy was achieved with less than ten movements of the catheter. These results suggest that ISGA has potential to provide accurate and efficient guidance for RFA procedures in the patient population with hemodynamically unstable arrhythmias.
New Generation of Plasma‐Sprayed Mullite Coatings on Silicon Carbide (1995)

Mullite is promising as a protective coating for silicon‐based ceramics in aggressive high‐temperature environments. Conventionally plasma‐sprayed mullite on SiC tends to crack and debond on thermal cycling. It is shown that this behavior is due to the presence of amorphous mullite in the conventionally sprayed mullite. Heating the SiC substrate during the plasma spraying eliminated the amorphous phase and produced coatings with dramatically improved properties. The new coating exhibits excellent adherence and crack resistance under thermal cycling between room temperature and 1000–1400°C. Preliminary tests showed good resistance to Na 2 CO 3 ‐induced hot corrosion.
Synthesis gas from gaseous CO/sub 2/-solid carbonaceous fuel feeds. [by continuous partial oxidation process in presence of gaseous CO/sub 2/] (1976)

This is an improved continuous partial oxidation process for producing synthesis gas or fuel gas from gaseous CO/sub 2/-solid carbonaceous fuel feeds. A solid carbonaceous fuel such as finely ground coal from a pressurized lock hopper is passed directly into a high pressure high velocity CO/sub 2/-rich gas stream which carries the particles of coal into a free-flow noncatalytic gas generator where by the partial oxidation reaction with a free-oxygen containing gas, preferably in the absence of supplemental H/sub 2/O other than that normally present in the reactants, gaseous mixtures principally comprising H/sub 2/, CO, CO/sub 2/, and H/sub 2/O are produced. A CO/sub 2/-rich gas stream is recovered downstream in the process and recycled to the pressurized feed system. The CO/sub 2/-rich stream serves as a carrier for the carbonaceous fuel and as a reactant in the reaction zone.
Acceleration methods for radiance transfer in photorealistic augmented reality (2013)

Radiance transfer computation from unknown real-world environments is an intrinsic task in probe-less photometric registration for photorealistic augmented reality, which affects both the accuracy of the real-world light estimation and the quality of the rendering. We discuss acceleration methods that can reduce the overall ray-tracing costs for computing the radiance transfer for photometric registration in order to free up resources for more advanced augmented reality lighting. We also present evaluation metrics for a systematic evaluation.
Structure–Property Relations in Oligomers of Linear Aliphatic Diisocyanates (2018)

Oligomerization reactions of aliphatic diisocyanates, exclusively involving NCO groups are discussed. The reactivity and selectivity of these reactions are dependent on chain length, reaction conditions, and the catalyst employed. The resulting oligomers (“dimers” and “trimers”) sometimes deviate considerably from expectation with respect to the structure and properties. The synthesis and characterization of well-known derivatives such as uretdiones and isocyanurates are discussed, and special attention is devoted to the recently developed iminooxadiazinedione chemistry. Finally, a new class of compounds is introduced, the tricyclic diiminooxadiazinones.
MIX: a meta-data indexing system for XML (2005)

We present a system for efficient meta-data indexed querying of XML documents. Given the diversity of the information available in XML, it is very useful to annotate XML data with a wide variety of meta-data, such as quality and security assessments. We address the meta-data indexing problem of efficiently identifying the XML elements along a location step in an XPath query, that satisfy meta-data range constraints. Our system, named MIX, incorporates query processing on all XPath axes suitably enhanced with meta-data features offering not only query answering but also dynamic maintenance of meta-data levels for XML documents.