gebhart/patrepeval huggingface dataset:
High energy storage density and efficiency in nanostructured (Bi <sub>0.2</sub> Na <sub>0.2</sub> K <sub>0.2</sub> La <sub>0.2</sub> Sr <sub>0.2</sub> )TiO <sub>3</sub> high‐entropy ceramics (2021)

Abstract High‐entropy ceramics (HECs) (Bi 0.2 Na 0.2 K 0.2 La 0.2 Sr 0.2 )TiO 3 (BNKLST) with single‐phase perovskite structure have been successfully prepared by a modified citrate acid method. In comparison to (Bi 0.5 Na 0.5 )TiO 3 (BNT) ceramics prepared by the same synthesis route, the BNKLST HECs exhibit dense nanostructures with grain sizes as small as 45 nm, which are suggested to be responsible for the significantly improved electric breakdown fields and reduced leakage currents in the ceramics, and they have much enhanced elastic modulus owing to the entropy‐stabilized perovskite structure. The electrical and dielectric characterizations reveal that BNKLST has high electrical resistances and dielectric constants at elevated temperatures, and, in particular, a recoverable energy storage density of 0.959 J/cm 3 can be achieved under an applied electric field of 180 kV/cm. Moreover, the energy storage efficiency in BNKLST can be maintained to be larger than 90% at 40–200°C. These excellent properties suggest that entropy‐stabilized BNT‐based ceramics are promising dielectrics for electrical energy storage applications.
Physical and mechanical properties of ultra‐oriented high‐density polyethylene fibers (1979)

Abstract Ultra‐oriented high‐density polyethylene fibers (HDPE) have been prepared by solid‐state extrusion over 60–140°C range using capillary draw ratios up to 52 and extrusion pressures of 0.12 to 0.49 GPa. The properties of the fibers have been assessed by birefringence, thermal expansivity, differential scanning calorimetry, x‐ray analysis, and mechanical testing. A maximum birefringence of 0.0637 ± 0.0015 was obtained, greater than the calculated value of 0.059 for the intrinsic birefringence of the orthorhombic crystal phase. The maximum modulus obtained was 70 GPa. The melting point, density, crystallinity, and negative thermal expansion coefficient parallel to the fiber axis all increase rapidly with draw ratio and at draw ratios of 20–30 attain limiting values comparable with those of a polyethylene single crystal. The properties of the fibers have been analyzed using the simple rule of mixtures, assuming a two‐phase model of crystalline and noncrystalline microstructure. The orientation of the noncrystalline phase with draw ratio was determined by birefringence and x‐ray measurements. Solid‐state extrusion of HDPE near the ambient melting point produced a c ‐axis orientation of 0.996 and a noncrystalline orientation function of 0.36. Extrusion 50°C below the ambient melting point produced a decrease in crystallinity, c ‐axis orientation, melting point, and birefringence, but the noncrystalline orientation increased at low draw ratios and was responsible for the increased thermal shrinkage of the fibers.
Bioreactor Performance in Anaerobic Digestion of Fruit and Vegetable Wastes (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
IN VITRO PROPAGATION AND HOMING OF LIVER-DERIVED DENDRITIC CELL PROGENITORS TO LYMPHOID TISSUES OF ALLOGENEIC RECIPIENTS (1995)

Dendritic cell (DC) progenitors were propagated in liquid culture from nonparenchymal cells resident in normal mouse (B10.BR; H-2k, I-E+) liver in response to granulocyte-macrophage colony stimulating factor (GM-CSF). The liver-derived DC progenitors were MHC class II-/dim and did not express counter receptors for CTLA-4, a structural homologue of the T cell activation molecule CD28. Following subcutaneous or intravenous injection, these liver-derived cells migrated to T cell-dependent areas of lymph nodes and spleen of unmodified, allogeneic (B10; H-2b; I-E-) recipients, where they were identified 1-5 days, and 1 and 2 months after injection by their strong surface expression of donor MHC class II (I-Ek) and their dendritic morphology. Maximal numbers of liver-derived DC in the spleen were recorded 5 days after injection. Both clusters of strongly donor MHC class II+ cells--and (more rarely) dividing cells--could also be identified, suggesting cell replication in situ. Using the same techniques employed to generate DC progenitors from normal liver, GM-CSF-stimulated cells were propagated for 10 days from the bone marrow and spleen of nonimmunosuppressed mice sacrificed 14 days after orthotopic liver transplantation (B10;H-2b-->C3H;H-2k). Immunocytochemical staining for recipient and donor MHC class II phenotype revealed the growth both of host cells with DC characteristics, and of cells expressing donor alloantigens (I-Ab). These results are consistent with the growth, in response to GM-CSF, of donor-derived DC from progenitors seeded from the liver allograft to recipient lymphoid tissue. The functional activity of the progenitors of chimeric DC and the possible role of these cells in the establishment and maintenance of donor-specific tolerance following liver transplantation remain to be determined.
Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration (2018)

Therapeutic monoclonal antibodies and endogenous IgG antibodies show limited uptake into the central nervous system (CNS) due to the blood-brain barrier (BBB), which regulates and controls the selective and specific transport of both exogenous and endogenous materials to the brain. The use of natural transport mechanisms, such as receptor-mediated transcytosis (RMT), to deliver antibody therapeutics into the brain have been studied in rodents and monkeys. Recent successful examples include monovalent bispecific antibodies and mono- or bivalent fusion proteins; however, these formats do not have the capability to bind to both the CNS target and the BBB transport receptor in a bivalent fashion as a canonical antibody would. Dual-variable-domain immunoglobulin (DVD-Ig) proteins offer a bispecific format where monoclonal antibody-like bivalency to both the BBB receptor and the therapeutic target is preserved, enabling independent engineering of binding affinity, potency, valency, epitope and conformation, essential for successful generation of clinical candidates for CNS applications with desired drug-like properties. Each of these parameters can affect the binding and transcytosis ability mediated by different receptors on the brain endothelium differentially, allowing exploration of diverse properties. Here, we describe generation and characterization of several different DVD-Ig proteins, specific for four different CNS targets, capable of crossing the BBB through transcytosis mediated by the transferrin receptor 1 (TfR1). After systemic administration of each DVD-Ig, we used two independent methods in parallel to observe specific uptake into the brain. An electrochemiluminescent-based sensitive quantitative assay and a semi-quantitative immunohistochemistry technique were used for brain concentration determination and biodistribution/localization in brain, respectively. Significantly enhanced brain uptake and retention was observed for all TfR1 DVD-Ig proteins regardless of the CNS target or the systemic administration route selected.
Physico-chemical studies for strontium sulfate radiation dosimeter (2015)

Anhydrous strontium sulfate (SrSO4) has shown a promise candidate as a dosimeter for low dose applications producing unique EPR signals with γ-rays which it has a linear response relationship (r2 = 0.999) in the range of 1–100 Gy. The present study extended to evaluate the properties of strontium sulfate dosimeter in intermediate dose range of technology applications. It was observed that the intensity of the EPR signal at g = 2.01081 increases with a 3rd polynomial function in the range of 0.10–15 kGy. In addition, the radical (SO4−) provides a stable signal with a good reproducibility (0.107%). Other physics characteristic including the collision of mass stopping power dependence of the system and the effect of atomic number in different energy regions were investigated. The uncertainty budget for high doses has obtained from the measurement with value of 3.57% at 2σ confidence level.
Time-delayed 2-Pulse Studies of MALDI Matrix Ionization Mechanisms (2000)

Individually subthreshold, time-delayed 355 nm laser pulses were used to investigate matrix-assisted laser desorption/ionization (MALDI) ion formation time scales for the matrix 2,5 dihydroxybenzoic acid. With 30 ps pulses, it was possible to identify a prompt, subnanosecond, mechanism and a slow, nanosecond, process involving at least two steps.
Different glycosyltransferases are differentially processed for secretion, dimerization, and autoglycosylation (2003)

Modification of Golgi glycosyltransferases, such as formation of disulfide-bonded dimers and proteolytical release from cells as a soluble form, are important processes to regulate the activity of glycosyltransferases. To better understand these processes, six glycosyltransferases were selected on the basis of the donor sugars, including two N-acetylglucosaminyltransferases, core 1 beta1,3-N-acetylglucosaminyltransferase (C1-beta3GnT) and core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT-I); two fucosyltransferases, alpha1,2-fucosyltransferase-I (FucT-I) and alpha1,3-fucosyltransferase-VII (FucT-VII); and two sialyltransferases, alpha2,3-sialyltransferase-I (ST3Gal-I) and alpha2,6-sialyltransferase-I (ST6Gal-I). These enzymes were fused with enhanced green fluorescence protein and stably expressed in Chinese hamster ovary cells. Spectrofluorimetric detection and immunoblotting analyses showed that all of these glycosyltransferases except FucT-VII were secreted in the medium. By examining dimers formed in cells and culture media, we found that all of the enzymes, except ST3Gal-I, form a combination of monomers and dimers in cells, whereas the molecules released in the media are either exclusively monomers (C2GnT-I and ST6Gal-I), dimers (FucT-I) or a mixture of both (C1-beta3GnT). These results indicate that dimerization does not always lead to Golgi retention. Analysis of the N-glycosylation status of the enzymes revealed that the secreted proteins are generally more heavily N-glycosylated and sialylated than their membrane-associated counterparts, suggesting that the proteolytic cleavage occurs before the glycosylation is completed. Using FucT-I and ST6Gal-I as a model, we also show that these glycosyltransferases are able to perform autoglycosylation in the dimeric forms. These results indicate that different glycosyltranferases differ significantly in dimerization, proteolytic digestion and secretion, and autoglycosylation. These results strongly suggest that disulfide-bonded dimerization and secretion differentially plays a role in the processing and function of different glycosyltransferases in the Golgi apparatus.
Smart Contract SLAs for Dense Small-Cell-as-a-Service (2017)

The disruptive power of blockchain technologies represents a great opportunity to re-imagine standard practices of telecommunication networks and to identify critical areas that can benefit from brand new approaches. As a starting point for this debate, we look at the current limits of infrastructure sharing, and specifically at the Small-Cell-as-a-Service trend, asking ourselves how we could push it to its natural extreme: a scenario in which any individual home or business user can become a service provider for mobile network operators, freed from all the scalability and legal constraints that are inherent to the current modus operandi. We propose the adoption of smart contracts to implement simple but effective Service Level Agreements (SLAs) between small cell providers and mobile operators, and present an example contract template based on the Ethereum blockchain.
PointCom: semi-autonomous UGV control with intuitive interface (2008)

Unmanned ground vehicles (UGVs) will play an important role in the nation's next-generation ground force. Advances in sensing, control, and computing have enabled a new generation of technologies that bridge the gap between manual UGV teleoperation and full autonomy. In this paper, we present current research on a unique command and control system for UGVs named <b>PointCom</b> (Point-and-Go Command). PointCom is a semi-autonomous command system for one or multiple UGVs. The system, when complete, will be easy to operate and will enable significant reduction in operator workload by utilizing an intuitive image-based control framework for UGV navigation and allowing a single operator to command multiple UGVs. The project leverages new image processing algorithms for monocular visual servoing and odometry to yield a unique, high-performance fused navigation system. Human Computer Interface (HCI) techniques from the entertainment software industry are being used to develop video-game style interfaces that require little training and build upon the navigation capabilities. By combining an advanced navigation system with an intuitive interface, a semi-autonomous control and navigation system is being created that is robust, user friendly, and less burdensome than many current generation systems. mand).
Real time and online dynamic speckle assessment of growing bacteria using the method of motion history image (2016)

This paper reports the application of the motion history image (MHI) method for biospeckle processing of a bacterial growth. The method avoids the complexity as well as the large computation in sequence-matching-based methods and detects whether the speckle structure has changed or not. Encouraging experimental results on the real-time evolution of the growing bacteria during 12 h demonstrate the effectiveness of the proposed method. The MHI presented an online result without loss of resolution and definition. In turn, the MHI also presented the ability to provide a close answer to the traditional offline method of generalized differences.
Antisense Down-Regulation of <i>4CL</i> Expression Alters Lignification, Tree Growth, and Saccharification Potential of Field-Grown Poplar   (2010)

Transgenic down-regulation of the Pt4CL1 gene family encoding 4-coumarate:coenzyme A ligase (4CL) has been reported as a means for reducing lignin content in cell walls and increasing overall growth rates, thereby improving feedstock quality for paper and bioethanol production. Using hybrid poplar (Populus tremula × Populus alba), we applied this strategy and examined field-grown transformants for both effects on wood biochemistry and tree productivity. The reductions in lignin contents obtained correlated well with 4CL RNA expression, with a sharp decrease in lignin amount being observed for RNA expression below approximately 50% of the nontransgenic control. Relatively small lignin reductions of approximately 10% were associated with reduced productivity, decreased wood syringyl/guaiacyl lignin monomer ratios, and a small increase in the level of incorporation of H-monomers (p-hydroxyphenyl) into cell walls. Transgenic events with less than approximately 50% 4CL RNA expression were characterized by patches of reddish-brown discolored wood that had approximately twice the extractive content of controls (largely complex polyphenolics). There was no evidence that substantially reduced lignin contents increased growth rates or saccharification potential. Our results suggest that the capacity for lignin reduction is limited; below a threshold, large changes in wood chemistry and plant metabolism were observed that adversely affected productivity and potential ethanol yield. They also underline the importance of field studies to obtain physiologically meaningful results and to support technology development with transgenic trees.
Concentration and molecular weight dependence of viscoelastic properties in linear and star polymers (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConcentration and molecular weight dependence of viscoelastic properties in linear and star polymersV. R. Raju, E. V. Menezes, G. Marin, W. W. Graessley, and L. J. FettersCite this: Macromolecules 1981, 14, 6, 1668–1676Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/ma50007a011https://doi.org/10.1021/ma50007a011research-articleACS PublicationsRequest reuse permissionsArticle Views1108Altmetric-Citations190LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Increased memory performance during vector accesses through the use of linear address transformations (1992)

A technique to analyze transformation matrices is presented. This technique is based on decomposing complex transformations into elementary transformations. When combined with a factorization of the access stride into two components, one a power of 2 and the other relatively prime to 2, the technique leads to an algorithmic synthesis of a CF (conflict free) storage scheme. Additionally, because the address to storage location mapping arithmetic is performed modulo 2, the time required to transform an address to its corresponding storage location is smaller and the hardware cost is lower than if schemes based on row rotation were used.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nogo-A Expression in the Human Hippocampus in Normal Aging and in Alzheimer Disease (2006)

Myelin-associated proteins are involved in the formation and stabilization of myelin sheaths. In addition, they prevent axon regeneration and plasticity in the adult brain. Recent evidence suggests that the expression of certain myelin-associated proteins (e.g. Nogo-A) can be regulated by synaptic activity or by over-expression after neural lesions in brain syndromes such as temporal lobe epilepsy. However, no studies on Alzheimer disease (AD) have been reported in which cell loss and significant synaptic reorganization occurs. In the present study, we analyze in detail the expression of Nogo-A in the hippocampal formation in normal human aging and in AD. Our results indicate that Nogo-A is expressed by oligodendrocytes and neurons in the aged hippocampal formation. In addition, both granule cells and mossy fiber connections are also labeled in the old-aged hippocampi. Interestingly, Nogo-A is over-expressed by hippocampal neurons in AD and is associated with beta-amyloid deposits in senile plaques. Taken together, our results reinforce the hypothesis that Reticulon proteins such as Nogo-A participate in the neuronal responses stemming from hippocampal formation during senescence, and particularly in AD. These findings also indicate that Reticulon proteins could be considered as new putative drug targets in therapies of neurodegenerative disorders.
Practical design of switched-capacitor networks for integrated circuit implementation (1979)

Switched-capacitor (s.c.) networks are of great interest owing to their compatibility with m.o.s.i.c. technology. It is shown how s.c. networks can be derived directly from continuous active RC networks. The corresponding network functions in z are obtained from those in s by using a simple ‘p-transformation’. It is shown that s.c. networks can also be designed directly. The resulting networks are often more versatile than those derived from another circuit type or technology. Numerous examples of both approaches to s.c. network and filter design are given and experimental results presented. Excellent agreement between theory and practice has been obtained.
A monoclonal antibody to VIII:C produced by a mouse hybridoma (1981)

Abstract Spleen cells of a BALB/c mouse immunized with factor VIII procoagulant activity (VIII:C) (isolated by affinity chromatography) were fused with mouse myeloma cells (P3 x 63 Ag8). After the fusion 12/32 wells produced an inhibitor to VIII:C. Cells from one well (1B3) were subcloned four times in order to isolate the hybridoma that produces the anti-VIII:C antibody. Injection of hybridoma cells in pristane pretreated BALB/c mice results in anti-VIII:C titers of 5000–10,000 Bethesda U/ml. Analysis of the produced immunoglobulin demonstrated heavy chains of IgG1 (produced by the myeloma cell line) and IgG2b subclass. The 1B3 antibody neutralizes VIII:C in LMW FVIII, crysosupernatant, cryoprecipitate, and normal plasma. It was found that binding of the IgG to FVIII results in a delay in its activation and not in an inhibition of its cofactor activity. The antibody removes VIII:C from pooled normal plasma when coupled to Sepharose; when coupled to plastic tubes, it binds VIIICAG from isolated VIII:C, purified FVIII, and pooled normal plasma; it does not bind VIIIR:AG, fibrogen, or serum VIIICAG. The 1B3 antibody can be used successfully in an IRMA for VIIICAG.
The Outward Bound Canoeing Handbook (1992)

Veteran paddlers Landry and McNair, in conjunction with the world-famous Outward Bound organization, offer a solid grounding in the fundamentals of canoeing, including techniques, equipment, and safety skills.
A new skin biopsy system for use with small cetaceans (2010)

1 Laboratorio de Mamiferos Aquaticos e Bioindicadores, Faculdade de Oceanografia, Instituto de Geociencias, Universidade do Estado do Rio de Janeiro, Rua Sao Francisco Xavier 524, Bloco E, Sala 4002, Maracana, 20550-013, Rio de Janeiro, RJ, Brazil 2 Laboratorio de Biodiversidade Molecular, Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Brazil * Corresponding author, e-mail: haydeecunha@ufrj.br http://dx.doi.org/10.5597/lajam00168
A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β<sup>−</sup>-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative (2012)

For the first time, to our knowledge, 4 terbium radionuclides have been tested in parallel with tumor-bearing mice using an FR targeting agent. Along with excellent tumor visualization enabled by (152)Tb PET and (155)Tb SPECT, we demonstrated the therapeutic efficacy of the α-emitter (149)Tb and β(-)-emitter (161)Tb.
BoB, a best-of-breed automated text de-identification system for VHA clinical documents (2012)

Our system successfully addressed VHA clinical document de-identification, and its hybrid stepwise design demonstrates robustness and efficiency, prioritizing patient confidentiality while leaving most clinical information intact.