gebhart/patrepeval huggingface dataset:
Hamiltonian control design for DC microgrids with stochastic sources and loads with applications (2014)

To achieve high performance operation of micro-grids that contain stochastic sources and loads is a challenge that will impact cost and complexity. Developing alternative methods for controlling and analyzing these systems will provide insight into tradeoffs that can be made during the design phase. This paper presents a design methodology, based on Hamiltonian Surface Shaping and Power Flow Control (HSSPFC) [1] for a hierarchical control scheme that regulates renewable energy sources and energy storage in a DC micro-grid. Recent literature has indicated that there exists a trade-off in information and power flow and that intelligent, coordinated control of power flow in a microgrid system can modify energy storage hardware requirements. Two scenarios are considered; i) simple two stochastic source with variable load renewable DC Microgrid example and ii) a three zone electric ship with DC Microgrid and varying pulse load profiles.
Detection of antibodies to hepatitis C virus in U.S. blood donors (1991)

An enzyme immunoassay (EIA) which utilizes a solid phase coated with a recombinant antigen (c100-3) derived from the hepatitis C virus (HCV) genome was evaluated for efficacy in the detection of antibodies to HCV (anti-HCV). The sensitivity of the antibody test was demonstrated by the detection of anti-HCV in a well-characterized panel of human specimens known to contain the infectious agent of non-A, non-B hepatitis. The specificity of the anti-HCV test was evaluated by testing 6,118 serum specimens from volunteer blood donors considered to be at low risk for exposure to HCV. The specificity of the anti-HCV EIA was demonstrated to be 99.56%, since 6,069 of 6,096 specimens from this low-risk group were nonreactive. A total of 49 (0.80%) of the 6,118 specimens were repeatedly reactive in the test, and 22 (46.81%) of the 47 specimens available for additional testing were confirmed as positive for antibodies to HCV c100-3. Among commercial plasma donors, 390 (10.49%) of 3,718 specimens were repeatedly reactive in the EIA. A total of 375 (97.40%) of the 385 specimens available for further testing were confirmed as positive. These limited data indicate that the prevalence of antibodies to HCV is 0.36% (22 confirmed positives among 6,118 specimens) among volunteer blood donors and 10.08% (375 confirmed positives among 3,718 specimens) among commercial plasma donors. The importance of confirmatory testing is discussed.
Exploiting the control of phase in marine vibrators (2016)

Marine seismic vibrators are considered to be more environmentally friendly than air guns and this has prompted a resurgence of interest in their use. However, these devices have novel features that are potentially of great benefit to seismic imaging and that have not yet been exploited - in particular, we can control the phase. With marine vibrators, the emitted waveform can be chosen freely, provided that it lies within the envelope of what the device can emit. Typically, the waveform is a swept-frequency sinusoid. In this paper, we show how the sweep phase can be used to suppress the residual shot noise (RSN) and to separate simultaneous sources of high multiplicity. This work is also described by Laws and Halliday (2013) and is closely related to that of Laws (2012). The control of phase is a benefit of marine vibrators that can be exploited to great effect. First, we look at the RSN situation. The conventional wisdom is that roughly a 10s shot-time interval is required in marine seismic data acquisition so that the RSN is acceptably small relative to the signal. Because both signal and RSN originate from the seismic source, the ratio of signal/RSN is not improved by using a larger source (pace Landrø, 2008). We show a simple case of RSN attenuation using alternating sine and cosine sweeps. That is to say, the sequence of source phases goes, for successive shots, [0° 90° 0° 90° 0° 90° 0° 90°... and so on]. We show schematically how this ‘phase sequencing’ leads to a dramatic attenuation of the RSN. It does so by moving the RSN into parts of the frequency-wavenumber spectrum where there is no signal. We then use frequency-wavenumber filtering to remove the RSN. This can be done with simple filtering up to the limit imposed by spatial aliasing and beyond that limit by using wavefield reconstruction methods, such as generalized matching pursuit (Özbek et al., 2010; Vassallo et al., 2010). Reconstruction methods decompose the seismic wavefield into a set of basis functions that allow the signal and RSN to be identified and separated. Then, we look at the simultaneous source situation. The RSN removal problem can be considered as a special case of the more general simultaneous source separation problem. As an example, in the case of two simultaneous sources, one source can be swept with consistent phase, while the other source is swept with alternating phase, i.e., the sequence of relative phases is [0° 180° 0° 180° 0° 180° 0° 180°... and so on]. The simultaneous source separation is demonstrated using the same type of reconstruction method as described above for the RSN. See also Moore et al. (2008) and Ji et al. (2012). The use of phase sequencing opens up possibilities for simultaneous source separation using large numbers of sources. By having complete control over the phases of all the sources it is possible, in certain domains, to make simultaneous source data look similar to aliased data from a single source. This opens the door to using many established wavefield interpolation and dealiasing-techniques to perform high-multiplicity simultaneous source separation.
Diagnosis of Toxoplasmosis Using a Synthetic Glycosylphosphatidylinositol Glycan (2014)

Around 2 billion people worldwide are infected with the apicomplexan parasite Toxoplasma gondii which induces a variety of medical conditions. For example, primary infection during pregnancy can result in fetal death or mental retardation of the child. Diagnosis of acute infections in pregnant women is challenging but crucially important as the drugs used to treat T. gondii infections are potentially harmful to the unborn child. Better, faster, more reliable, and cheaper means of diagnosis by using defined antigens for accurate serological tests are highly desirable. Synthetic pathogen-specific glycosylphosphatidylinositol (GPI) glycan antigens are diagnostic markers and have been used to distinguish between toxoplasmosis disease states using human sera.
Giant energy density in [001]-textured Pb(Mg1/3Nb2/3)O3-PbZrO3-PbTiO3 piezoelectric ceramics (2013)

Pb(Zr,Ti)O3 (PZT) based compositions have been challenging to texture or grow in a single crystal form due to the incongruent melting point of ZrO2. Here we demonstrate the method for achieving 90% textured PZT-based ceramics and further show that it can provide highest known energy density in piezoelectric materials through enhancement of piezoelectric charge and voltage coefficients (d and g). Our method provides more than ∼5× increase in the ratio d(textured)/d(random). A giant magnitude of d·g coefficient with value of 59 000 × 10−15 m2 N−1 (comparable to that of the single crystal counterpart and 359% higher than that of the best commercial compositions) was obtained.
Magnetic needle rheometer (1989)

A magnetic needle rheometer has been developed. Its principle of operation is identical to the one of a magnetic sphere rheometer, except that the magnetic sphere is replaced by a magnetic needle. Important advantages result from this modification: (i) The lower limit of measurable viscosities (≂0.3 cP) becomes several orders of magnitude lower; (ii) analytic expressions for shear rate and shear stress have been derived; (iii) the needle can be covered by using a quartz capillary tubing, which is chemically much more inert than any magnetic material; (iv) precise determinations (±0.1%) of fluid densities, especially at high temperatures, are possible; and (v) the cost of manufacturing magnetic needles is much lower than for magnetic spheres. The device has been tested with viscosity standards.
Oxygen Sensitivity of Algal H2-Production (1997)

Photoproduction of H2 by green algae utilizes electrons originating from the photosynthetic oxidation of water and does not require metabolic intermediates. However, algal hydrogenases are extremely sensitive to O2, which limits their usefulness in future commercial H2-production systems. We designed an experimental technique for the selection of O2-tolerant, H2-producing variants of Chlamydomonas reinhardtii based on the ability of wild-type cells to survive a short (20 min) exposure to metronidazole in the presence of controlled concentrations of O2. The number of survivors depends on the metronidazole concentration, light intensity, preinduction of the hydrogenase, and the presence or absence of O2. Finally, we demonstrate that some of the selected survivors in fact exhibit H2-production capacity that is less sensitive to O2 than the original wild-type population.
Permanent Revocation in Attribute Based Broadcast Encryption (2012)

We propose a new and efficient scheme for broadcast encryption. A broadcast encryption system allows a broadcaster to send an encrypted message to a dynamically chosen subset RS, |RS|=n, of a given set of users, such that only users in this subset can decrypt the message. An important component of broadcast encryption schemes is revocation of users by the broadcaster, thereby updating the subset RS. Revocation may be either temporary, for a specific cipher text, or permanent. In the existing public key schemes which support temporary revocation of the users, the broadcaster is required to keep track of the revoked users. We present the first public key broadcast encryption scheme that supports permanent revocation of users. Unlike previous schemes, the broadcaster in our scheme should not keep track of the revoked users (saving memory and computation power). Our scheme is fully collusion-resistant. In other words, even if all the revoked users collude, the revoked user cannot encrypt messages without receiving new keys from the broadcaster. The procedure is based on Cipher-text Policy Attribute-Based Encryption (CP-ABE). The overhead of revocation in our system is constant in all major performance measures including length of private and public keys, computational complexity, user's storage space, and computational complexity of encryption and decryption. The scheme we construct improves on our original scheme in a poster presentation [7] by a factor of O(log n) in all major performance measures.
Local insulin therapy affects fracture healing in a rat model (2012)

A significant number of lower extremity fractures result in mal-union necessitating effective treatments to restore ambulation. Prior research in diabetic animal fracture models demonstrated improved healing following local insulin application to the fracture site and indicated that local insulin therapy can aid bone regeneration, at least within an insulin-dependent diabetic animal model. This study tested whether local insulin therapy could accelerate femur fracture repair in normal, non-diabetic rats. High (20 units) and low (10 units) doses of insulin were delivered in a calcium sulfate carrier which provided sustained release of the exogenous insulin for 7 days after fracture. Histomorphometry, radiographic scoring, and torsional mechanical testing were used to measure fracture healing. The fracture calluses from rats treated with high-dose insulin had significantly more cartilage than untreated rats after 7 and 14 days of healing. After 4 weeks of healing, femurs from rats treated with low-dose insulin had significantly higher radiographic scores and mechanical strength (p < 0.05), compared to the no treatment control groups. The results of this study suggest that locally delivered insulin is a potential therapeutic agent for treating bone fractures. Further studies are necessary, such as large animal proof of concepts, prior to the clinical use of insulin for bone fracture treatment.
Diode-pumped very large core, gain guided, index antiguided single mode fiber laser (2009)

Single-mode laser action, up to 4-times the threshold power, in a diode-pumped Nd-doped phosphate glass fiber having a 300-µm core is demonstrated. Subtle differences associated with the effectiveness of diode-pumping gain-guided, index-antiguided fibers are discussed.
Removal of lead, cadmium and zinc from aqueous solutions by precipitation with sodium Di‐(<i>n</i>‐octyl) phosphinate (2000)

Abstract Sodium di‐( n ‐octyl) phosphinate (NaL) was used as a precipitating agent to remove heavy metals from aqueous nitrate solutions. Cadmium, zinc and mixtures of lead, cadmium and zinc were precipitated in the form of PbL 2(s) , CdL 2(s) , and ZnL 2(s) . Lowering the pH of the feed solution reduced the removal of the metals as some of the phosphinate precipitated in the acid form as HL (S) . The removal of lead, cadmium, and zinc, from a solution containing the three metals gave a selectivity in the order Zn > Pb > Cd. Predictions of an equilibrium‐constant model, using measured solubility products of the precipitates and literature values of stability constants, gave metal removals, loss of precipitating agent, and equilibrium pH in good agreement with measured values.
Physiologic expansion of human heart-derived cells enhances therapeutic repair of injured myocardium (2019)

Continuous physiological cell culture increased cell growth, paracrine output, and treatment outcomes to provide the greatest functional benefit after experimental myocardial infarction.
The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells (2005)

Down-regulation of the androgen receptor (AR) is being evaluated as an effective therapy for the advanced stages of prostate cancer. We report that Ebp1, a protein identified by its interactions with the ErbB3 receptor, down-regulates expression of AR and AR-regulated genes in the LNCaP prostate cancer cell line. Using microarray analysis, we identified six endogenous AR target genes, including the AR itself, that are down-regulated by ebp1 overexpression. Chromatin immunoprecipitation assays revealed that Ebp1 was recruited to the prostate-specific antigen gene promoter in response to the androgen antagonist bicalutamide, suggesting that Ebp1 directly affected the expression of AR-regulated genes in response to androgen antagonists. Ebp1 expression was reduced in cells that had become androgen-independent. Androgens failed to stimulate either the growth of ebp1 transfectants or transcription of AR-regulated reporter genes in these cells. The agonist activity of the antiandrogen cyproterone acetate was abolished in ebp1 transfectants. In severe combined immunodeficient mice, Ebp1 overexpression resulted in a reduced incidence of LNCaP tumors and slower tumor growth. These findings suggest that Ebp1 is a previously unrecognized therapeutic target for treatment of hormone refractory prostate cancer.
Rapid non-invasive mechanical imaging using line-scanning Brillouin microscopy (Conference Presentation) (2017)

Brillouin spectroscopy is able to measure material’s mechanical properties by analyzing the optical spectrum of acoustically-induced light scattering within a sample. In the past decade, the development of high-resolution Brillouin spectrometers based on virtually-imaged phased array (VIPA) has greatly increased the spectral detection efficiency thus enabling mechanical characterization of biological tissue and biomaterials. Further improvements in spectrometer performances have enabled in vivo measurements at safe power levels and 2D/3D imaging of biological cells. However, it remains a slow technique compared to other imaging modalities, because only one point of the sample can be measured by the traditional backward-scattering configuration at a time. In this work, we demonstrate a parallel detection configuration with 90-degree geometry where the Brillouin shift of hundreds of points in a line can be measured simultaneously. In a 1.1mm-by-1.5mm samples, this novel configuration effectively shortens the acquisition time of 2D Brillouin imaging from hours to ~30 seconds with spatial resolution of ~3um, thus making it a powerful technology for label-free mechanical characterization of tissue and biomaterials.
CANVAS: computer-assisted narrative animation synthesis (2016)

Despite the maturity in solutions for animating expressive virtual characters, innovations realizing the creative intent of story writers have yet to make the same strides. The key challenge is to provide an accessible, yet expressive interface for story authoring that enables the rapid prototyping, iteration, and deployment of narrative concepts. We present CANVAS, a computer-assisted visual authoring tool for synthesizing multi-character animations from sparsely-specified narrative events. In a process akin to storyboarding, authors lay out the key plot points in a story, and our system automatically fills in the missing details to synthesize a 3D animation that meets author constraints. CANVAS can be used by artists and directors to pre-visualize storyboards in an iterative fashion, and casual users may provide arbitrarily sparse specifications and harness automation to rapidly generate diverse narratives. CANVAS provides an accessible interface for rapidly authoring and pre-visualizing complex narratives. Automation reduces the authoring effort further without undermining creative control or interfering with the storytelling process.
A 10-bit 500-MS/s Partial-Interleaving Pipelined SAR ADC With Offset and Reference Mismatch Calibrations (2016)

A 10-bit 500-MS/s partial-interleaving pipelined successive approximation register (SAR) analog-to-digital converter (ADC) architecture is presented that implements a full-speed 2-bit/cycle SAR at the front end with interleaved residue MDACs and SAR ADCs at the back end. This architecture achieves high speed, while preventing the interleaving spurs. In addition, the design considerations and calibration techniques for gain and offset are also introduced. A histogram stage gain error (HSGE) calibration is implemented to correct the conversion nonlinearities in the digital domain. Measurement results on a 65-nm CMOS prototype show an signal-to-noise distortion ratio (SNDR) of 55.9 dB at dc input and a figure of merit (FoM) of 32 fJ/conversion step at 1.2 V supply.
Adenosine A <sub>3</sub> Receptor Expression and Function in Mitochondria (2016)

Mitochondrial dysfunction is emerging as a common mechanism of a variety of neurodegenerative diseases, including chemotherapy‐induced neuropathic pain. We have recently found that administration of selective agonists to the G protein‐coupled, adenosine A 3 receptor (A 3 AR) prevents the development of chemotherapy‐induced mitochondrial dysfunction in peripheral sensory neurons that result peripheral neuropathy and chronic pain. Recent evidence also indicates the presence of G proteins and G‐coupled protein receptors within mitochondria, including the adenosine A 1 and A 2A receptors. Bioinformatic analysis revealed potential mitochondrial‐associated sequences in published A 3 AR protein sequences, thus prompting us to hypothesize that A 3 AR is associated with mitochondria and its signaling could regulate mitochondrial function. Using Western blot analysis and transmission immune‐electron microscopy, we report for the first time that A 3 AR is present in normal rat mitochondria purified from liver, spinal cord and peripheral blood lymphocytes. Moreover, we also report that when normal rodent mitochondria are pretreated with the selective A 3 AR agonist, MRS5890, they produced more ATP following ADP‐stimulation than mitochondria treated with its vehicle (0.002% DMSO). We also find that MRS5980 counteracts normal mitochondrial membrane depolarization during calcium mobilization. Collectively, our data provide the first evidence for the presence A 3 AR in mitochondria and initial mechanistic insight to its functional role in mitochondria that potentially could serve as a target for the treatment of neurodegenerative disease. Support or Funding Information NIH‐NCI CA169519
High Resolution Magic Angle Spinning 1H-NMR Metabolic Profiling of Nanoliter Biological Tissues at High Magnetic Field (2013)

It is demonstrated that a high resolution magic angle spinning 1H-NMR spectrum of biological tissue samples with volumes as small as 150 nanoliters, or 0.15 mg in weight, can be acquired in a few minutes at 21.1 T magnetic field using a commercial 1.6 mm fast-MAS probe with minor modification of the MAS rotor. The strategies of sealing the samples inside the MAS rotor to avoid fluid leakage as well as the ways of optimizing the signal to noise are discussed.
<title>Subpixel shift with Fourier transform to achieve efficient and high-quality image interpolation</title> (1999)

A new approach to image interpolation is proposed. Different from the conventional scheme, the interpolation of a digital image is achieved with a sub-unity coordinate shift technique. In the approach, the original image is first shifted by sub-unity distances matching the locations where the image values need to be restored. The original and the shifted images are then interspersed together, yielding an interpolated image. High quality sub-unity image shift which is crucial to the approach is accomplished by implementing the shift theorem of Fourier transformation. It is well known that under the Nyquist sampling criterion, the most accurate image interpolation can be achieved with the interpolating function (sinc function). A major drawback is its computation efficiency. The present approach can achieve an interpolation quality as good as that with the sinc function since the sub-unity shift in Fourier domain is equivalent to shifting the sinc function in spatial domain, while the efficiency, thanks to the fast Fourier transform, is very much improved. In comparison to the conventional interpolation techniques such as linear or cubic B-spline interpolation, the interpolation accuracy is significantly enhanced. In order to compensate for the under-sampling effects in the interpolation of 3D medical images owing to a larger inter-slice distance, proper window functions were recommended. The application of the approach to 2- and 3-D CT and MRI images produced satisfactory interpolation results.