gebhart/patrepeval huggingface dataset:
Defining attributes for scorecard construction in credit scoring (2000)

In many domains, simple forms of classification rules are needed because of requirements such as ease of use. A particularly simple form splits each variable into just a few categories, assigns weights to the categories, sums the weights for a new object to be classified, and produces a classification by comparing the score with a threshold. Such instruments are often called scorecards. We describe a way to find the best partition of each variable using a simulated annealing strategy. We present theoretical and empirical comparisons of two such additive models, one based on weights of evidence and another based on logistic regression.
Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma (2016)

Glioblastomas (GBM), deadly brain tumors, have greater incidence in males than females. Epidemiological evidence supports a tumor suppressive role of estrogen; however, estrogen as a potential therapy for GBM is limited due to safety concerns. Since GBM express ERβ, a second receptor for estrogen, targeting ERβ with a selective agonist may be a potential novel GBM therapy. In the present study, we examined the therapeutic effect of the selective synthetic ERβ agonist LY500307 using in vitro and in vivo GBM models. Treatment with LY500307 significantly reduced the proliferation of GBM cells with no activity on normal astrocytes in vitro. ERβ agonists promoted apoptosis of GBM cells, and mechanistic studies using RNA sequencing revealed that LY500307 modulated several pathways related to apoptosis, cell cycle, and DNA damage response. Further, LY500307 sensitized GBM cells to several FDA-approved chemotherapeutic drugs including cisplatin, lomustine and temozolomide. LY500307 treatment significantly reduced the in vivo tumor growth and promoted apoptosis of GBM tumors in an orthotopic model and improved the overall survival of tumor-bearing mice in the GL26 syngeneic glioma model. Our results demonstrate that LY500307 has potential as a therapeutic agent for GBM.
Management of Massive Air Embolism during Open-heart Surgery with Retrograde Perfusion of the Cerebral Vessels and Hyperbaric Oxygenation (1983)

Retrograde perfusion through the superior vena cava was used in 2 patients who were injured by massive air embolism occurring during open-heart surgery. They underwent hyperbaric treatment immediately following completion of the intracardiac repair. Both patients made complete recovery and were discharged, with no defects attributable to the incident.
The Synthesis and Ion Bindings of Synthetic Multidentate Macrocyclic Compounds (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleThe Synthesis and Ion Bindings of Synthetic Multidentate Macrocyclic CompoundsJames J. Christensen, Delbert J. Eatough, and Reed M. IzattCite this: Chem. Rev. 1974, 74, 3, 351–384Publication Date (Print):June 1, 1974Publication History Published online1 May 2002Published inissue 1 June 1974https://pubs.acs.org/doi/10.1021/cr60289a003https://doi.org/10.1021/cr60289a003research-articleACS PublicationsCopyright © 2002 Request reuse permissionsArticle Views1730Altmetric-Citations644LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives (1989)

Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).
Two Modes of Transcriptional Activation at Native Promoters by NF-κB p65 (2009)

The NF-kappaB family of transcription factors is crucial for the expression of multiple genes involved in cell survival, proliferation, differentiation, and inflammation. The molecular basis by which NF-kappaB activates endogenous promoters is largely unknown, but it seems likely that it should include the means to tailor transcriptional output to match the wide functional range of its target genes. To dissect NF-kappaB-driven transcription at native promoters, we disrupted the interaction between NF-kappaB p65 and the Mediator complex. We found that expression of many endogenous NF-kappaB target genes depends on direct contact between p65 and Mediator, and that this occurs through the Trap-80 subunit and the TA1 and TA2 regions of p65. Unexpectedly, however, a subset of p65-dependent genes are transcribed normally even when the interaction of p65 with Mediator is abolished. Moreover, a mutant form of p65 lacking all transcription activation domains previously identified in vitro can still activate such promoters in vivo. We found that without p65, native NF-kappaB target promoters cannot be bound by secondary transcription factors. Artificial recruitment of a secondary transcription factor was able to restore transcription of an otherwise NF-kappaB-dependent target gene in the absence of p65, showing that the control of promoter occupancy constitutes a second, independent mode of transcriptional activation by p65. This mode enables a subset of promoters to utilize a wide choice of transcription factors, with the potential to regulate their expression accordingly, whilst remaining dependent for their activation on NF-kappaB.
Study of the mechanism of <i>Flavobacterium</i> sp. for hydrolyzing organophosphate pesticides (2003)

The biotransformation by Flavobacterium sp. of the following organophosphate pesticides was experimentally and theoretically studied: phorate, tetrachlorvinphos, methyl-parathion, terbufos, trichloronate, ethoprophos, phosphamidon, fenitrothion, dimethoate and DEF. The Flavobacterium sp. ATCC 27551 strain bearing the organophosphate-degradation gene was used. Bacteria were incubated in the presence of each pesticide for a duration of 7 days. Parent pesticides were identified and quantified by means of a gas-chromatography mass spectrum system. Activity was considered as the amount (micromol) of each pesticide degraded by Flavobacterium sp. Also, structural parameters obtained by means of the CAChe program package for biomolecules, the reactivity index of phosphorus, of oxygen at the P = O function and of sulfur at the P = S function, and lipophilicity (log Poct) (ALOGPS v. 2.0) were obtained for each pesticide. Pesticides were hydrolyzed at the bond between phosphorous and the heteroatom, producing phosphoric acid and three metabolites. Enzymatic activity was significantly explained by the following multiple linear relationship: Enzymatic activity = 162.2 - 9.5(dihedral angle energy) - 25.0(Total energy) - 0.51(Molecular weight). Finally, a mechanism of Flavobacterium sp. to hydrolyze pesticides was proposed.
Morphological characterization of GFP stably transfected adult mesenchymal bone marrow stem cells (2006)

Increasing attention is being given to the use of adult rather than embryonic stem cells, both for research and for the development of transplantation treatments for human disease. In particular, mesenchymal bone marrow stem cells have been studied extensively because of their ability to self-renew and to give rise to various differentiated cell types, and because of the relative ease with which they can be obtained and cultured. In addition, the possibility of labelling stem cells with green fluorescent protein before transplantation has opened new and promising perspectives for their use in basic research. Because no structural or ultrastructural description of adult mesenchymal stem cells is available in the literature, this paper describes their morphology as revealed by light, confocal and electron microscopy, focusing on cells that are particularly suitable for transplantation studies, i.e. those derived from rat bone marrow transfected with green fluorescent protein. The results provide a basis for experimental studies of the differentiation of these cells in normal and pathological tissues.
Simulation studies for the ATLAS upgrade Strip tracker (2017)

ATLAS is making extensive efforts towards preparing a detector upgrade for the High luminosity operations of the LHC (HL-LHC), which will commence operation in ~10 years. The current ATLAS Inner Detector will be replaced by a all-silicon tracker (comprising an inner Pixel tracker and outer Strip tracker). The software currently used for the new silicon tracker is broadly inherited from that used for the LHC Run 1 and 2, but many new developments have been made to better fulfil the future detector and operation requirements. One aspect in particular which will be highlighted is the simulation software for the Strip tracker. The available geometry description software (including the detailed description for all the sensitive elements, the services, etc.) did not allow for accurate modeling of the planned detector design. A range of sensors/layouts for the Strip tracker are being considered and must be studied in detailed simulations in order to assess the performance and ascertain that requirements are met. For this, highly flexibility geometry building is required from the simulation software. A new Xml-based detector description framework has been developed to meet the aforementioned challenges. We will present the design of the framework and its validation results.
Through the years with on-a-chip gas chromatography: a review (2015)

In recent years, the need for measurement and detection of samples in situ or with very small volume and low concentration (low and sub-parts per billion) is a cause for miniaturizing systems via microelectromechanical system (MEMS) technology. Gas chromatography (GC) is a common technique that is widely used for separating and measuring semi-volatile and volatile compounds. Conventional GCs are bulky and cannot be used for in situ analysis, hence in the past decades many studies have been reported with the aim of designing and developing chip-based GC. The focus of this review is to follow and investigate the development and the achievements in the field of chip-based GC and its components from the beginning up to the present.
Lens Films and Reflective Polarization Films (2009)

This chapter contains sections titled: Introduction Fundamentals of Reflection and Refraction Lens Films (Upward Direction) Lens Films (Downward Direction) Reflective Polarization Films Resin-type Specular Reflection Films Applications of Films Standards References
LA PROTECTION INTERNATIONALE DES PERSONNES DÉPLACÉES; UN AUTHENTIQUE BESOIN DE DÉVELOPPEMENT NORMATIF ? (2023)

LA PROTECTION INTERNATIONALE DES PERSONNES DÉPLACÉES; UN AUTHENTIQUE BESOIN DE DÉVELOPPEMENT NORMATIF ?. Un article de la revue Revue québécoise de droit international / Quebec Journal of International Law / Revista quebequense de derecho internacional (Volume 11, numéro 1, 1998, p. I-421) diffusée par la plateforme Érudit.
Role of the Major Antigen of <i>Mycobacterium tuberculosis</i> in Cell Wall Biogenesis (1997)

The dominant exported proteins and protective antigens of Mycobacterium tuberculosis are a triad of related gene products called the antigen 85 (Ag85) complex. Each has also been implicated in disease pathogenesis through its fibronectin-binding capacities. A carboxylesterase domain was found within the amino acid sequences of Ag85A, B, and C, and each protein acted as a mycolyltransferase involved in the final stages of mycobacterial cell wall assembly, as shown by direct enzyme assay and site-directed mutagenesis. Furthermore, the use of an antagonist (6-azido-6-deoxy-alpha, alpha'-trehalose) of this activity demonstrates that these proteins are essential and potential targets for new antimycobacterial drugs.
Effects of <i>Enterococcus faecalis fsr</i> Genes on Production of Gelatinase and a Serine Protease and Virulence (2000)

Three agr-like genes (fsrA, fsrB, and fsrC, for Enterococcus faecalis regulator) were found upstream of the previously reported gelatinase gene (gelE) and a downstream putative serine protease gene (sprE; accession number Z12296) of Enterococcus faecalis OG1RF. The deduced amino acid sequence of fsrA shows 26% identity and 38% similarity to Staphylococcus aureus AgrA (the response regulator of the accessory gene regulator system in the agr locus), FsrB shows 23% identity and 41% similarity to S. aureus AgrB, and FsrC shows 23% identity and 36% similarity to S. aureus AgrC (the sensor transducer of Agr system). Northern blot analysis suggested that gelE and sprE are cotranscribed and that fsrB and fsrC are also cotranscribed in OG1RF. Northern blot analysis of fsrA, fsrB, fsrC, gelE, and sprE insertion mutants showed that fsrB, fsrC, gelE, and sprE are not expressed in fsrA, fsrB, and fsrC mutants, while insertion in an open reading frame further upstream of fsrA did not effect the expression of these genes, suggesting that agr-like genes may be autoregulated and that they regulate gelE and sprE expression, as further confirmed by complementation of fsr gene mutations with a 6-kb fragment which contains all three fsr genes in the shuttle vector, pAT18. Testing of 95 other isolates of E. faecalis showed that 62% produced gelatinase (Gel(+)), while 91% (including all Gel(+) strains) hybridized to a gelE probe; 71% (including all Gel(+) strains) hybridized to an fsr probe, corroborating the conclusion that both gelE and fsr are necessary for gelatinase production. Testing of fsrA, fsrB, and sprE mutants in a mouse peritonitis model showed that sprE and agr-like gene mutants resulted in highly significantly prolonged survival compared to the parent strain OG1RF, a finding similar to what we had previously shown for a gelE mutant. These results suggest that sprE and agr-like genes contribute to the virulence of E. faecalis OG1RF in this model.
The tumour suppressor gene <i>CEACAM1</i> is completely but reversibly downregulated in renal cell carcinoma (2004)

CEACAM1 acts as a tumour suppressor in various epithelial tumours. On the other hand, de novo expression of CEACAM1 is strongly associated with reduced disease-free survival of melanoma and non-small cell lung carcinoma patients. Since effector functions of natural killer and T cells are inhibited by homophilic CEACAM1 interaction, immune escape could be responsible for the poor prognosis of these patients. Here, we describe CEACAM1 expression in normal kidney, renal adenomas and renal cell carcinomas (RCC) using a novel antibody generated by genetic immunization. In normal kidney, CEACAM1 was found in epithelial cells of proximal tubules and in endothelial cells. In contrast, tumour cells of 30 clear cell, three chromophobic, and two chromophilic RCCs were completely devoid of CEACAM1. Renal adenomas also lacked CEACAM1 expression. Similarly, RCC cell lines CaKi1, CaKi2, A498, and RCC26 exhibited no or low-level CEACAM1 expression. However, CEACAM1 expression was transiently induced in A498 cells upon contact with allogeneic CD8+ T cells, mediated at least in part by interferon-gamma. Furthermore, the majority of tumour-infiltrating T and NK cells expressed CEACAM1 upon stimulation. Thus, transient expression of the tumour suppressor CEACAM1 by tumour cells and subsequent homophilic interaction with CEACAM1 on tumour-infiltrating lymphocytes could represent a novel immune escape mechanism in RCC.
Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. (2002)

Epidemiological evidence suggests a geographical basis for the incidence of prostate cancer and dietary factors, including isoflavone consumption, may be linked to this phenomenon. This paper reports a nonrandomized, nonblinded trial with historically matched controls from archival tissue designed to determine the effects of acute exposure to a dietary supplement of isoflavones in men with clinically significant prostate cancer before radical prostatectomy. Thirty-eight patients were recruited to the study upon diagnosis of prostate cancer. Before surgery, 20 men consumed 160 mg/day of red clover-derived dietary isoflavones, containing a mixture of genistein, daidzein, formononetin, and biochanin A. Serum PSA, testosterone, and biochemical factors were measured, and clinical and pathological parameters were recorded. The incidence of apoptosis in prostate tumor cells from radical prostatectomy specimens was compared between 18 treated and 18 untreated control tissues. There were no significant differences between pre- and posttreatment serum PSA, Gleason score, serum testosterone, or biochemical factors in the treated patients (P > 0.05). Apoptosis in radical prostatectomy specimens from treated patients was significantly higher than in control subjects (P = 0.0018), specifically in regions of low to moderate-grade cancer (Gleason grade 1-3). No adverse events related to the treatment were reported. This report suggests that dietary isoflavones may halt the progression of prostate cancer by inducing apoptosis in low to moderate-grade tumors, potentially contributing to the lower incidence of clinically significant disease in Asian men. The assessment of new prostatic therapies aimed at increasing apoptosis should control for intake of dietary isoflavones.
Synthetic Nucleic Acid Analogues in Gene Therapy: An Update for Peptide–Oligonucleotide Conjugates (2017)

The main objective of this work is to provide an update on synthetic nucleic acid analogues and nanoassemblies as tools in gene therapy. In particular, the synthesis and properties of peptide-oligonucleotide conjugates (POCs), which have high potential in research and as therapeutics, are described in detail. The exploration of POCs has already led to fruitful results in the treatment of neurological diseases, lung disorders, cancer, leukemia, viral, and bacterial infections. However, delivery and in vivo stability are the major barriers to the clinical application of POCs and other analogues that still have to be overcome. This review summarizes recent achievements in the delivery and in vivo administration of synthetic nucleic acid analogues, focusing on POCs, and compares their efficiency.
Long-term database support for EXPRESS data (2002)

The data modeling language STEP/EXPRESS enjoys a spreading popularity beyond engineering. Its structural object orientation, for instance, is appropriate for scientific and statistical database (SSDB) modeling as well. As our database prototype illustrates, EXPRESS can also be used for data definition. Following the STEP approach, data manipulation is done via SDAI (Standard Data Access Interface). Besides increasing awareness of evolving STEP technology, this paper elaborates on a common issue of both engineering databases and SSDBs: the long-term retention of vast amounts of data. The storage of massive data over decades imposes serious problems on any DBMS. Application-oriented database archiving helps solve them. We indicate how to exploit and enhance SDAI to make it an archive interface.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Observer for DC voltages in a cascaded H-bridge multilevel STATCOM (2007)

Using an instantaneous model of a cascade H-bridge multilevel-based STATCOM, an observer for estimating the DC capacitor voltages of the multilevel inverter is presented. This design can be used to eliminate the voltage sensors in each H-bridge of this device. Simulation results are presented in order to validate the performance of the proposed observer applied to a cascade H-bridge multilevel-based STATCOM.
The Dark Side(-Channel) of Mobile Devices: A Survey on Network Traffic Analysis (2018)

In recent years, mobile devices (e.g., smartphones and tablets) have met an increasing commercial success and have become a fundamental element of the everyday life for billions of people all around the world. Mobile devices are used not only for traditional communication activities (e.g., voice calls and messages) but also for more advanced tasks made possible by an enormous amount of multi-purpose applications (e.g., finance, gaming, and shopping). As a result, those devices generate a significant network traffic (a consistent part of the overall Internet traffic). For this reason, the research community has been investigating security and privacy issues that are related to the network traffic generated by mobile devices, which could be analyzed to obtain information useful for a variety of goals (ranging from fine-grained user profiling to device security and network optimization). In this paper, we review the works that contributed to the state of the art of network traffic analysis targeting mobile devices. In particular, we present a systematic classification of the works in the literature according to three criteria: 1) the goal of the analysis; 2) the point where the network traffic is captured; and 3) the targeted mobile platforms. In this survey, we consider points of capturing such as Wi-Fi access points, software simulation, and inside real mobile devices or emulators. For the surveyed works, we review and compare analysis techniques, validation methods, and achieved results. We also discuss possible countermeasures, challenges, and possible directions for future research on mobile traffic analysis and other emerging domains (e.g., Internet of Things). We believe our survey will be a reference work for researchers and practitioners in this research field.
Glycoconjugated porphyrins. 2. Synthesis of sterically constrained polyglycosylated compounds derived from tetraphenylporphyrins (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlycoconjugated porphyrins. 2. Synthesis of sterically constrained polyglycosylated compounds derived from tetraphenylporphyrinsPhilippe Maillard, Jean Luc Guerquin-Kern, Christiane Huel, and Michel MomenteauCite this: J. Org. Chem. 1993, 58, 10, 2774–2780Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/jo00062a020https://doi.org/10.1021/jo00062a020research-articleACS PublicationsRequest reuse permissionsArticle Views408Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts