gebhart/patrepeval huggingface dataset:
Characterization of a commercial multileaf collimator used for intensity modulated radiation therapy (2001)

The characteristics of a commercial multileaf collimator (MLC) to deliver static and dynamic multileaf collimation (SMLC and DMLC, respectively) were investigated to determine their influence on intensity modulated radiation therapy (IMRT) treatment planning and quality assurance. The influence of MLC leaf positioning accuracy on sequentially abutted SMLC fields was measured by creating abutting fields with selected gaps and overlaps. These data were also used to measure static leaf positioning precision. The characteristics of high leaf-velocity DMLC delivery were measured with constant velocity leaf sequences starting with an open field and closing a single leaf bank. A range of 1-72 monitor units (MU) was used providing a range of leaf velocities. The field abutment measurements yielded dose errors (as a percentage of the open field max dose) of 16.7+/-0.7% mm(-1) and 12.8+/-0.7% mm(-1) for 6 MV and 18 MV photon beams, respectively. The MLC leaf positioning precision was 0.080+/-0.018 mm (single standard deviation) highlighting the excellent delivery hardware tolerances for the tested beam delivery geometry. The high leaf-velocity DMLC measurements showed delivery artifacts when the leaf sequence and selected monitor units caused the linear accelerator to move the leaves at their maximum velocity while modulating the accelerator dose rate to deliver the desired leaf and MU sequence (termed leaf-velocity limited delivery). According to the vendor, a unique feature to their linear accelerator and MLC is that the dose rate is reduced to provide the correct cm MU(-1) leaf velocity when the delivery is leaf-velocity limited. However, it was found that the system delivered roughly 1 MU per pulse when the delivery was leaf-velocity limited causing dose profiles to exhibit discrete steps rather than a smooth dose gradient. The root mean square difference between the steps and desired linear gradient was less than 3% when more than 4 MU were used. The average dose per MU was greater and less than desired for closing and opening leaf patterns, respectively, when the delivery was leaf-velocity limited. The results indicated that the dose delivery artifacts should be minor for most clinical cases, but limit the assumption of dose linearity when significantly reducing the delivered dose for dosimeter characterization studies or QA measurements.
Priority queues and sorting methods for parallel simulation (2000)

The authors examine the design, implementation, and experimental analysis of parallel priority queues for device and network simulation. They consider: 1) distributed splay trees using MPI; 2) concurrent heaps using shared memory atomic locks; and 3) a new, more general concurrent data structure based on distributed sorted lists, designed to provide dynamically balanced work allocation and efficient use of shared memory resources. We evaluate performance for all three data structures on a Cray-TSESOO system at KFA-Julich. Our comparisons are based on simulations of single buffers and a 64/spl times/64 packet switch which supports multicasting. In all implementations, PEs monitor traffic at their preassigned input/output ports, while priority queue elements are distributed across the Cray-TBE virtual shared memory. Our experiments with up to 60000 packets and two to 64 PEs indicate that concurrent priority queues perform much better than distributed ones. Both concurrent implementations have comparable performance, while our new data structure uses less memory and has been further optimized. We also consider parallel simulation for symmetric networks by sorting integer conflict functions and implementing a packet indexing scheme. The optimized message passing network simulator can process /spl sim/500 K packet moves in one second, with an efficiency that exceeds /spl sim/50 percent for a few thousand packets on the Cray-T3E with 32 PEs. All developed data structures form a parallel library. Although our concurrent implementations use the Cray-TSE ShMem library, portability can be derived from Open-MP or MP1-2 standard libraries, which will provide support for one-way communication and shared memory lock mechanisms.
Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer (2014)

Semaphorin-3A is a chemorepellent guidance protein that is crucial in regulating the tumor microenvironment. MMP-14, a membrane-anchored matrix metalloproteinase, is closely associated with extracellular matrix (ECM) remodeling and cell migration in the progression of cancer metastasis. In the present study, the correlation between the expression levels of semaphorin-3A and MMP-14, and their subsequent prognostic significance in non-small cell lung cancer (NSCLC), was investigated. The expression of semaphorin-3A and MMP-14 protein levels was analyzed in 94 cases of NSCLC tissues and in 80 cases of normal lung tissues, using immunohistochemistry (IHC). Correlation and survival analysis were used to further investigate their association and prognostic value. The results revealed that the NSCLC tissues exhibited a lower expression of semaphorin-3A and a higher expression of MMP-14 than in the control lung tissues. The downregulation of semaphorin-3A and upregulation of MMP-14 may promote pleural invasion, lymph node metastasis, vascular invasion and proliferating cell nuclear antigen expression. The expression of semaphorin-3A was correlated with the maximum diameter of tumor. There was a negative correlation between the protein expression levels of semaphorin-3A and MMP-14 in NSCLC tissues. Furthermore, we identified that the patients with lower expression of semaphorin-3A and a higher expression of MMP-14 had worse disease prognosis. The data suggest that lower expression of semaphorin-3A and a higher expression of MMP-14 may promote occurrence and development in NSCLC and that the combined detection of semaphorin-3A and MMP-14 protein may be a helpful tool in predicting the prognosis of NSCLC.
[End-systolic pressure-volume relationships obtained by conductance catheter and transient inferior vena caval occlusion: their clinical usefulness]. (1991)

Whether beneficial hemodynamic effects of cardiovascular drugs are due to changes in the inotropic or loading conditions has been difficult to determine in clinical settings. In this study, the end-systolic pressure-volume relationship, known as a load-independent measurement of cardiac contractility, was obtained by a volumetric conductance catheter and transient inferior vena caval occlusion. We applied this technique to determine the major mode of hemodynamic action of a new inotropic vasodilator, OPC-8490, in comparison to that of dobutamine. In 7 patients with anterior myocardial infarction, an 8F conductance catheter with pressure micromanometer was inserted into the left ventricle. Absolute volume calibration was accomplished by injection of hypertonic saline into the pulmonary artery. Left ventricular pressures and volumes were simultaneously and continuously measured during transient inferior vena caval occlusion using a balloon catheter. Left ventricular end-systolic pressure-volume relationships were determined during the initial 8-sec of balloon occlusion, before baroreceptor-mediated cardiac stimulation was initiated. OPC-8490 decreased both the left ventricular systolic pressure and end-systolic volume without changing the heart rate. Dobutamine increased the systolic pressure and heart rate but decreased the end-systolic volume. The reduction in the end-systolic volume with dobutamine, was caused by an increase in the slope of the end-systolic pressure-volume relationship, while with OPC-8490, it resulted from a decrease in the end-systolic pressure without an appreciable change in the slope of the end-systolic pressure-volume relationship.(ABSTRACT TRUNCATED AT 250 WORDS)
Iron Aluminide Hot Gas Filters (1996)

Currently, high temperature filter systems are in the demonstration phase with the first commercial scale hot filter systems being installed on integrated gasification combined cycle (IGCC) and pressurized fluid bed combustion cycle (PBFC) systems (70 MW). They are dependent on the development of durable and economic high temperature filter systems. These filters are mostly ceramic tubes or candles. Ceramic filter durability has not been high. Failure is usually attributed to mechanical or thermal shock: they can also undergo significant changes due to service conditions. The overall objective of this project is to commercialize weldable, crack resistant filters which will provide several years service in advanced power processes. The specific objectives of this project are to develop corrosion resistant alloys and manufacturing processes to make Iron Aluminide filter media, and to use a ``short term`` exposure apparatus supported by other tests to identify the most promising candidate (alloy plus sintering cycle). The objectives of the next phases are to demonstrate long term corrosion stability for the best candidate followed by the production of fifty filters (optional).
Effect of motion cues during complex curved approach and landing tasks: A piloted simulation study (1987)

A piloted simulation study was conducted to examine the effect of motion cues using a high-fidelity simulation of a commercial airplane during the performance of complex curved approach and landing tasks in the signal environment of the microwave landing system (MLS). The data from these tests indicate that in a high-complexity MLS approach task with moderate turbulence and wind, the pilot uses motion cues to improve path tracking performance. No significant differences in tracking accuracy were noted for the low- and medium- complexity tasks, regardless of the presence of motion cues. Higher control- input rates were measured for all the tasks when motion was used. Pilot eye scan, as measured by instrument dwell time, was faster when motion cues were used regardless of the complexity of the approach tasks. A pilot subjective rating, based on time load, mental effort load, and psychological stress load, yielded larger work load ratings with motion than with no motion. Pilot comments indicated that they preferred motion and that motion cues helped them accomplish their task, especially in turbulence and during the landing phase of the approach. With motion cues, pilots appeared to work harder in all levels of task complexity and to improve tracking performance in the most complex approach task.
3-D array pattern synthesis with frequency Invariant property for concentric ring array (2006)

This correspondence proposes a method for array pattern synthesis of a concentric ring array that yields invariant array pattern over a certain frequency band for beamforming in three dimensions. The proposed method uses the Fourier-Bessel series to determine the weights from different rings to form the overall array pattern. Simulation examples are given to illustrate the proposed method.
Large-Scale Oil Palm Tree Detection from High-Resolution Satellite Images Using Two-Stage Convolutional Neural Networks (2018)

Being an important economic crop that contributes 35% of the total consumption of vegetable oil, remote sensing-based quantitative detection of oil palm trees has long been a key research direction for both agriculture and environmental purposes. While existing methods already demonstrate satisfactory effectiveness for small regions, performing the detection for a large region with satisfactory accuracy is still challenging. In this study, we proposed a two-stage convolutional neural network (TS-CNN)-based oil palm detection method using high-resolution satellite images (i.e. Quickbird) in a large-scale study area of Malaysia. The TS-CNN consists of one CNN for land cover classification and one CNN for object classification. The two CNNs were trained and optimized independently based on 20,000 samples collected through human interpretation. For the large-scale oil palm detection for an area of 55 km2, we proposed an effective workflow that consists of an overlapping partitioning method for large-scale image division, a multi-scale sliding window method for oil palm coordinate prediction, and a minimum distance filter method for post-processing. Our proposed approach achieves a much higher average F1-score of 94.99% in our study area compared with existing oil palm detection methods (87.95%, 81.80%, 80.61%, and 78.35% for single-stage CNN, Support Vector Machine (SVM), Random Forest (RF), and Artificial Neural Network (ANN), respectively), and much fewer confusions with other vegetation and buildings in the whole image detection results.
Retinal capillary pericyte proliferation and c-Fos mRNA induction by prostaglandin D2 through the cAMP response element. (2002)

PGD2 promotes the growth of retinal capillary pericytes by signaling through cAMP and CREB. The findings underscore the importance of PGs in the growth of human retinal capillary pericytes and raise the possibility that PGs may play a role in proliferative retinopathies.
Damage and Failure of Metal/Fibre‐Reinforced Polymer Tensile Specimens with Inelastic Interface (2010)

Abstract Hybrid specimens of metal and fibre‐reinforced polymer are applied in automotive and aerospace industry. The simulation and analysis of damage of such engineering structures is the focus of this research. The investigation includes a computation of the extension of single lap tensile specimen, produced by ultrasonic metal welding. The specimen is manufactured from CF‐PA66 ‐ fibre‐reinforced polymer and AlMg3 (AA5754), which is used as a metallic joining partner. The aluminium substrate is treated as an elastoplastic material. The polymer composite generally shows an orthotropic elastic behaviour. The interface material has been numerically modeled as an elastoplastic material with linear hardening, coupled with Lemaitre‐type damage. The finite element method is used for the investigation of so‐called interface elements. The geometry of the interface is a consequence of the welding sonotrode geometry. The behaviour of specimens with square and ring interface geometry are analysed. The influence of the interface geometry on the mechanical properties of the joint is shown. The increase of the damage parameter and the development of failure are described for both cases. (© 2010 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Performance evaluation of a hybrid MAC-layer protocol for hard real-time industrial networks (2002)

Operating features of a hybrid MAC-layer protocol (GIT-CSMA/CD) for industrial local area networks are described together with its computer simulated performance evaluation, under the assumption of station-based and message-based priorities. The implementation of GIT-CSMA/CD which is based partially on the capabilities and features of existing network controllers is presented.
[Prokaryotic expression of trigeminy artificial fusion gene of Leptospira interrogans and the immunogenicity of its products]. (2008)

The fusion gene lipL32/1-lipL21-OmpL1/2 and its prokaryotic expression system were successfully constructed in this study. The expressed fusion protein can be used as the antigen for developing universal genetic engineering vaccine and universal serological tests of leptospirosis.
Recovering Seismic Displacements through Combined Use of 1-Hz GPS and Strong-Motion Accelerometers (2007)

Retrieving displacement from seismic acceleration records is often difficult because unknown small baseline offsets in the acceleration time series will contaminate the doubly integrated record with large quadratic errors. One-hertz Global Positioning System (gps) position estimates and collocated seismic data are available from the 2003 M w 8 Tokachi-Oki (Hokkaido) earthquake. After a process of correcting for possible misorientation of the seismic sensors, an inversion method is used to simultaneously solve for ground displacement with both data sets as input constraints. This inversion method takes into account the presence of unknown offsets in the acceleration record, and the relatively large uncertainties in the estimated 1-Hz gps positions. In this study, 117 channels of seismic data were analyzed. Only 5% of the time does the static displacement retrieved from traditional baseline correction processing without gps information agree with the absolute displacement measured with 1-Hz gps to within the errors of the gps data. In solving simultaneously for constrained displacements that agree with both the seismic and gps data sets, an optimal solution was found that included only one- or two-step functions in the acceleration records. Potential explanations for the offsets are analyzed in terms of tilt of the sensor or electronic noise. For nine stations, clear misorientations of the seismic sensors of more than 20 deg from the reported orientation were found. For this size event, the 30-sec sampled gps solutions were also a sufficient constraint for establishing the offset errors and recovering reliable displacements. The results significantly extend the frequency band over which accelerometer data are reliable for source inversion studies. Online material: Plots of constrained seismograms with metadata.
<title>Progress on color night vision: visible/IR fusion, perception and search, and low-light CCD imaging</title> (1996)

We report progress on our development of a color night vision capability, using biological models of opponent-color processing to fuse low-light visible and thermal IR imagery, and render it in realtime in natural colors. Preliminary results of human perceptual testing are described for a visual search task, the detection of embedded small low-contrast targets in natural night scenes. The advantages of color fusion over two alterative grayscale fusion products is demonstrated in the form of consistent, rapid detection across a variety of low- contrast (+/- 15% or less) visible and IR conditions. We also describe advances in our development of a low-light CCD camera, capable of imaging in the visible through near- infrared in starlight at 30 frames/sec with wide intrascene dynamic range, and the locally adaptive dynamic range compression of this imagery. Example CCD imagery is shown under controlled illumination conditions, from full moon down to overcast starlight. By combining the low-light CCD visible imager with a microbolometer array LWIR imager, a portable image processor, and a color LCD on a chip, we can realize a compact design for a color fusion night vision scope.
How to train your neural ODE: the world of Jacobian and kinetic regularization (2020)

Training neural ODEs on large datasets has not been tractable due to the necessity of allowing the adaptive numerical ODE solver to refine its step size to very small values. In practice this leads to dynamics equivalent to many hundreds or even thousands of layers. In this paper, we overcome this apparent difficulty by introducing a theoretically-grounded combination of both optimal transport and stability regularizations which encourage neural ODEs to prefer simpler dynamics out of all the dynamics that solve a problem well. Simpler dynamics lead to faster convergence and to fewer discretizations of the solver, considerably decreasing wall-clock time without loss in performance. Our approach allows us to train neural ODE-based generative models to the same performance as the unregularized dynamics, with significant reductions in training time. This brings neural ODEs closer to practical relevance in large-scale applications.
Evidence for <i>Agrobacterium</i>-Induced Apoptosis in Maize Cells (2000)

Agrobacterium spp. can genetically transform most dicotyledonous plant cells whereas many monocot species are recalcitrant to Agrobacterium-mediated transformation. One major obstacle is that co-cultivation of Agrobacterium spp. with plant tissues often results in cell death. Report here is that, in maize tissues, this process resembles apoptosis, with characteristic DNA cleavage into oligonucleosomal fragments and morphological changes. Two anti-apoptotic genes from baculovirus, p35 and iap, had the ability to prevent the onset of apoptosis triggered by Agrobacterium spp. in maize tissues. p35 is reported to act as a direct inhibitor of a certain class of proteases (caspase) whereas i.a.p. may act upstream to prevent their activation. This evidence raises the possibility that caspase-like proteases may also be involved in the apoptotic pathway in plant cells.
Liver Sinusoidal Endothelial Cells Are Not Permissive for Adenovirus Type 5 (2000)

Adenoviral vectors are known to transduce hepatocytes in normal liver tissue with high efficiency. The aim of this study was to investigate whether sinusoidal endothelial cells, which separate hepatocytes from the bloodstream in the sinusoidal lumen, are permissive for infection by adenoviruses. We show here that microvascular liver sinusoidal endothelial cells are not infected by adenovirus type 5 in vivo or in vitro unless high MOIs are used. In contrast, macrovascular endothelial cells from aorta are efficiently infected by adenovirus type 5. In addition, Kupffer cells, similar to sinusoidal endothelial cells, are not infected by adenovirus type 5. Liver sinusoidal endothelial cells do not express the integrin receptor alpha(v)beta3, which is required for efficient infection by adenoviruses. Our results demonstrate that hepatocytes are the main cell population of the liver that is infected by adenovirus type 5.
Multiplex isothermal solid-phase recombinase polymerase amplification for the specific and fast DNA-based detection of three bacterial pathogens (2014)

We report on the development of an on-chip RPA (recombinase polymerase amplification) with simultaneous multiplex isothermal amplification and detection on a solid surface. The isothermal RPA was applied to amplify specific target sequences from the pathogens <i>Neisseria gonorrhoeae</i>, <i>Salmonella enterica</i> and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) using genomic DNA. Additionally, a positive plasmid control was established as an internal control. The four targets were amplified simultaneously in a quadruplex reaction. The amplicon is labeled during on-chip RPA by reverse oligonucleotide primers coupled to a fluorophore. Both amplification and spatially resolved signal generation take place on immobilized forward primers bount to expoxy-silanized glass surfaces in a pump-driven hybridization chamber. The combination of microarray technology and sensitive isothermal nucleic acid amplification at 38 °C allows for a multiparameter analysis on a rather small area. The on-chip RPA was characterized in terms of reaction time, sensitivity and inhibitory conditions. A successful enzymatic reaction is completed in <20 min and results in detection limits of 10 colony-forming units for methicillin-resistant <i>Staphylococcus aureus</i> and <i>Salmonella enterica</i> and 100 colony-forming units for <i>Neisseria gonorrhoeae</i>. The results show this method to be useful with respect to point-of-care testing and to enable simplified and miniaturized nucleic acid-based diagnostics. FigureThe combination of multiplex isothermal nucleic acid amplification with RPA and spatially-resolved signal generation on specific immobilized oligonucleotides.