gebhart/patrepeval huggingface dataset:
Near field x-ray lithography simulations for printing fine bridges (2003)

By using the near field in proximity x-ray lithography (PXL), a technique is demonstrated that extends beyond a resolution of 25 nm print feature size for dense lines. 'Demagnification by bias' of clear mask features is positively used in Fresnel diffraction together with multiple exposures of sharp peaks. Exposures are performed without lenses or mirrors between the mask and wafer, and 'demagnification' is achieved in a selectable range, 1 × –9 ×. The pitch is kept small by multiple stepped exposures of sharp, intense image peaks followed by single development. Low pitch nested lines are demonstrated. The optical field is kept compact at the mask. Since the mask–wafer gap scales as the square of the mask feature size, the mask feature sizes and mask–wafer gaps are comparatively large. Because the features are themselves larger, the masks are more easily manufactured. Meanwhile, exposure times for development levels high on sharp peaks are short, and there are further benefits including defect reduction, virtual elimination of sidebands, etc. A critical condition (CC) has been identified that is typically used for the highest resolution. Many devices, including batches of microprocessors, have been demonstrated previously by traditional 1 × PXL, which is the only next generation lithography developed and which is now further extended. For two-dimensional near field patterning, temporal and spatial incoherence at the CC have been used to show not only that peculiarities in the aerial pattern, such as 'ripple' and 'bright spots', can be virtually eliminated but also that there is an optimum demagnification, around 3 ×, in the Fresnel diffraction, where the contrast and, therefore, critical dimension control are highest. In the simulation of a bridge pattern, 'ripple' is likewise controlled. Blur and run-out are compared for various sources. Magnification corrections can be applied by various means. Extension to 15 nm printed features is predicted.
Copeptin is a strong and independent predictor of outcome in cardiogenic shock (2009)

Introduction There is considerable uncertainty about the reproducibility of the various instruments used to measure dyspnea, their ability to reflect changes in symptoms, whether they accurately reflect the patient's experience and if its evolution is similar between acute heart failure syndrome patients and nonacute heart failure syndrome patients. URGENT was a prospective multicenter trial designed to address these issues. Methods Patients were interviewed within 1 hour of first physician evaluation, in the emergency department or acute care setting, with dyspnea assessed by the patient using both a five-point Likert scale and a 10-point visual analog scale (VAS) in the sitting (60) and then supine (20) position if dyspnea had not been considered severe or very severe by the sitting versus decubitus dyspnea measurement. Results Very good agreements were found between the five-point Likert and VAS at baseline (0.891, P <0.0001) and between changes (from baseline to hour 6) in the five-point Likert and in VAS (0.800, P <0.0001) in acute heart failure (AHF) patients. Lower agreements were found when changes from baseline to H6 measured by Likert or VAS were compared with the seven-point comparative Likert (0.512 and 0.500 respectively) in AHF patients. The worse the dyspnea at admission, the greater the amplitude of improvement in the first 6 hours; this relationship is stronger when dyspnea is measured with VAS (Spearman's rho coefficient = 0.672) than with the five-point Likert (0.272) (both P <0.0001) in AHF patients. By the five-point Likert, only nine patients (3% (1% to 5%)) reported an improvement in their dyspnea, 177 (51% (46% to 57%)) had no change, and 159 (46% (41% to 52%)) reported worse dyspnea supine compared with sitting up in AHF patients. The PDA test with VAS was markedly different between AHF and non-AHF patients. Conclusions Both clinical tools five-point Likert and VAS showed very good agreement at baseline and between changes from baseline to tests performed 6 hours later in AHF patients. The PDA test with VAS was markedly different between AHF and non-AHF patients. Dyspnea is improved within 6 hours in more than threequarters of the patients regardless of the tool used to measure the change in dyspnea. The greater the dyspnea at admission, the greater the amplitude of improvement in the first 6 hours.
Quencher‐enhanced specificity of psoralen‐photosensitized virus inactivation in platelet concentrates (1994)

These findings suggest that the viral safety of PCs may be enhanced through treatment with AMT and UVA in the presence of flavonoids, and that flavonoid use may prove beneficial in other systems where oxygen-mediated damage occurs.
Toward whole-session relevance (2013)

Current research on web search has focused on optimizing and evaluating single queries. However, a significant fraction of user queries are part of more complex tasks [20] which span multiple queries across one or more search sessions [26,24]. An ideal search engine would not only retrieve relevant results for a user's particular query but also be able to identify when the user is engaged in a more complex task and aid the user in completing that task [29,1]. Toward optimizing whole-session or task relevance, we characterize and address the problem of intrinsic diversity (ID) in retrieval [30], a type of complex task that requires multiple interactions with current search engines. Unlike existing work on extrinsic diversity [30] that deals with ambiguity in intent across multiple users, ID queries often have little ambiguity in intent but seek content covering a variety of aspects on a shared theme. In such scenarios, the underlying needs are typically exploratory, comparative, or breadth-oriented in nature. We identify and address three key problems for ID retrieval: identifying authentic examples of ID tasks from post-hoc analysis of behavioral signals in search logs; learning to identify initiator queries that mark the start of an ID search task; and given an initiator query, predicting which content to prefetch and rank.
Droplet fragmentation using a mesh (2018)

Factors governing atomization of droplets impacting a mesh, starting with the elementary unit of a single hole, are investigated. It is shown how this process can be used to generate finely controlled sprays with micrometric droplet sizes and low kinetic energy, as is critical for agricultural applications.
Human topoisomerase IIα nuclear export is mediated by two CRM-1-dependent nuclear export signals (2004)

Resistance to chemotherapeutic drugs is a major obstacle in the treatment of leukemia and multiple myeloma. We have previously found that myeloma and leukemic cells in transition from low-density log phase conditions to high-density plateau phase conditions export substantial amounts of endogenous topoisomerase II alpha from the nucleus to the cytoplasm. In order for topoisomerase-targeted chemotherapy to function, the topoisomerase target must have access to the nuclear DNA. Therefore, the nuclear export of topoisomerase II alpha may contribute to drug resistance, and defining this mechanism may lead to methods to preclude this avenue of resistance. We have identified nuclear export signals for topoisomerase II alpha at amino acids 1017-1028 and 1054-1066, using FITC-labeled BSA-export signal peptide conjugates microinjected into the nuclei of HeLa cells. Functional confirmation of both signals (1017-1028 and 1054-1066) was provided by transfection of human myeloma cells with plasmids containing the gene for a full-length human FLAG-topoisomerase fusion protein, mutated at hydrophobic amino acid residues in the export signals. Of the six putative export signals tested, the two sites above were found to induce export into the cytoplasm. Export by both signals was blocked by treatment of the cells with leptomycin B, indicating that a CRM-1-dependent pathway mediates export. Site-directed mutagenesis of two central hydrophobic residues in either export signal in full-length human topoisomerase blocked export of recombinant FLAG-topoisomerase II alpha, indicating that both signals may be required for export. Interestingly, this pair of nuclear export signals (1017-1028 and 1054-1066) also defines a dimerization domain of the topoisomerase II alpha molecule.
Characterization of a chimeric monoclonal antibody against the insulin-like growth factor-I receptor (2009)

The insulin-like growth factors (IGFs) signaling system has been shown to play important roles in neoplasia. The IGF receptor type 1 (IGF-IR) is overexpressed in many types of solid and hematopoietic malignancies, and there is substantial experimental and clinical evidence that targeting IGF-IR is a promising therapeutic strategy against cancer. It has been previously reported that a mouse monoclonal antibody (mAb), 4G11, blocked IGF-I binding to IGF-IR and downregulated the IGF-IR in MCF-7 cells. We cloned this antibody, constructed a human-mouse chimeric antibody, designated m590, and characterized it. The chimeric IgG1 m590 bound to cell-associated IGF-IR on NWT c43 stably transfected cells and MCF-7 breast cancer cells as efficiently as the parental murine antibody. Using purified IGF-IR extracellular domains, we found that both the chimeric m590 and the parental 4G11 antibodies bind to conformational epitopes on IGF-IR. Neither of these antibodies bound to the insulin receptor (IR) ectodomain. Furthermore, IgG1 m590 blocked the binding of IGF-I and IGF-II to IGF-IR, and inhibited both IGF-I and IGF-II induced phosphorylation of IGF-IR in MCF-7 cells. These results suggest that m590 could be an useful antibody in diagnosis and treatment of cancer, as well as a research tool.
Quantum dot laser with 75nm broad spectrum of emission (2007)

We report on a quantum dot laser having an emission spectrum as broad as 74.9 nm at 25 degrees C in the 1.2-1.28 wavelength interval with a total pulsed output power of 750 mW in single lateral mode regime and the average spectral power density of >10 mW/nm. A significant overlap and approximate equalization of the ground-state and the excited-state emission bands in the laser's spectrum is achieved by means of intentional inhomogeneous broadening of the quantum dot energy levels.
Resonant harmonic response in tapping-mode atomic force microscopy (2004)

Higher harmonics in tapping-mode atomic force microscopy offers the potential for imaging and sensing material properties at the nanoscale. The signal level at a given harmonic of the fundamental mode can be enhanced if the cantilever is designed in such a way that the frequency of one of the higher harmonics of the fundamental mode (designated as the resonant harmonic) matches the resonant frequency of a higher-order flexural mode. Here we present an analytical approach that relates the amplitude and phase of the cantilever vibration at the frequency of the resonant harmonic to the elastic modulus of the sample. The resonant harmonic response is optimized for different samples with a proper design of the cantilever. It is found that resonant harmonics are sensitive to the stiffness of the material under investigation.
NIORAIM Integrity Monitoring Performance In Simultaneous Two-Fault Satellite Scenarios (2005)

The RAIM (Receiver Autonomous Integrity Monitoring) concept has been well known to the navigation community for more than a decade now, together with its shortcomings in availability. More recently, a new method called NIORAIM for achieving a better balancing of position accuracy with integrity was introduced using non-uniform weighting of the measurements. The method involves the selection of an optimum set of weights to get the lowest protection limit and efficient ways of evaluating the protection limit in light of the sub-optimality of the solution. The results from the analysis of NIORAIM performance showed that, for the NPA phase of flight where baro-aiding is available, about 50% of the unavailable geometries derived using standard RAIM-FDE could be salvaged when using NIORAIM. In this paper, the NIORAIM method will be extended to solve the problem of handling two simultaneous faults. Modifications to the NIORAIM algorithm are necessary to compute the horizontal integrity limit and evaluate the best set of weights under the new assumption of the worst case effect of encountering two satellite faults occurring simultaneously. NIORAIM was already a more complex algorithm than the original RAIM, particularly in the area of computing the integrity limits. With the two-fault assumption and its increased number of hypotheses resulting from the different paired satellite fault combinations, the ratio of the fault sizes between the two satellites of each pair must also be accounted for. The worst case ratio can be solved with Lagrangian multipliers when dealing with slopes in the noiseless analysis but the computational issues are less straightforward when accounting for noise. A design based on lookup tables with precomputed data will be presented in the paper that is amenable to real-time computation. The paper also discusses notions of designing a system to unify the handling of single and dual fault situations.
Spatial Mapping of Tracheal Ciliary Beat Frequency Using Real Time Phase-Resolved Doppler Spectrally Encoded Interferometric Microscopy (2019)

Ciliary motion in the upper airway is the primary mechanism by which the body transports foreign particulates out of the respiratory system in order to maintain proper respiratory function. The ciliary beating frequency (CBF) is often disrupted with the onset of disease as well as other conditions, such as changes in temperature or in response to drug administration. Current imaging of ciliary motion relies on microscopy and high-speed cameras, which cannot be easily adapted to in vivo imaging. M-mode optical coherence tomography (OCT) imaging is capable of visualization of ciliary activity, but the field of view is limited. We report on the development of a spectrally encoded interferometric microscopy (SEIM) system using a phase-resolved Doppler (PRD) algorithm to measure and map the ciliary beating frequency within an en face region. This novel high speed, high resolution system allows for the visualization of both temporal and spatial ciliary motion patterns as well as propagation of the metachronal wave. Rabbit tracheal CBF ranging from 9 to 13 Hz has been observed under different temperature conditions, and the effects of using lidocaine and albuterol have also been measured. This study is the stepping stone to in vivo studies and the translation of imaging spatial CBF to clinics.
Substrate specificity of lysophosphatidic acid acyltransferase β—evidence from membrane and whole cell assays (2005)

Membranes of mammalian cells contain lysophosphatidic acid acyltransferase (LPAAT) activities that catalyze the acylation of sn-1-acyl lysophosphatidic acid (lysoPA) to form phosphatidic acid. As the biological roles and biochemical properties of the six known LPAAT isoforms have yet to be fully elucidated, we have characterized human LPAAT-beta activity using two different assays. In a membrane-based assay, LPAAT-beta used lysoPA and lysophosphatidylmethanol (lysoPM) but not other lysophosphoglycerides as an acyl acceptor, and it preferentially transferred 18:1, 18:0, and 16:0 acyl groups over 12:0, 14:0, 20:0, and 20:4 acyl groups. The fact that lysoPM could traverse cell membranes permitted additional characterization of LPAAT-beta activity in cells: PC-3 and DU145 cells converted exogenously added lysoPM and (14)C-labeled 18:1 into (14)C-labeled phosphatidylmethanol (PM). The rate of PM formation was higher in cells that overexpressed LPAAT-beta and was inhibited by the LPAAT-beta inhibitor CT-32501. In contrast, if lysoPM and (14)C-labeled 20:4 were added to PC-3 or DU145 cells, (14)C-labeled PM was also formed, but the rate was neither higher in cells that overexpressed LPAAT-beta nor inhibited by CT-32501. We propose that LPAAT-beta catalyzes the intracellular transfer of 18:1, 18:0, and 16:0 acyl groups but not 20:4 groups to lysoPA.
Novel 1,2-Dithiins: Synthesis, Molecular Modeling Studies, and Antifungal Activity (1995)

The first structure-activity study involving the 1,2-dithiin class of compounds (1,2-dithiacyclohexadienes) is herein reported. A series of 3,6-disubstituted 1,2-dithiins was synthesized from dithiins 1d and 1e and evaluated as antifungal agents. A new and versatile synthesis of dithiins 1d and 1e is reported which is amenable to scale-up at the kilogram level. The novelty of the process derives from the use of beta-mercaptopropionitrile as the thiophile, relying on a beta-elimination strategy and subsequent oxidation to create the 1,2-dithiin ring. Optimal geometries of dithiins 1d, 18i, and 45 and model dithiin 61 were determined by molecular mechanics and Hartree-Fock molecular orbital calculations. Two possible mechanisms of action are presented for the 1,2-dithiin class of compounds to explain their observed antifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus.
Metastasis-Inducing S100A4 and RANTES Cooperate in Promoting Tumor Progression in Mice (2010)

Altogether, the data presented strongly validate the pro-metastatic function of S100A4 in the tumor microenvironment and define how the tumor cell-derived cytokine RANTES acts as a critical regulator of S100A4-dependent tumor cell dissemination. Additionally, for the first time we demonstrated the mechanism of S100A4 release associated with plasma membrane microparticle shedding from various cells types.
A Zero-IF Auto-Calibration System For Phased Array Antennas (2018)

A simple, compact, and low-cost implementation of an auto-calibration system for evaluating a Ka-band phased array active element is presented. The proposed technique estimates the amplitude/phase unbalance of each antenna element induced by feed circuit and characterizes phase shifter and variable gain amplifier (VGA) attached to each individual antenna element in an array configuration. This intelligent calibration system employs phased locked loop (PLL) oscillators to generate an RF test signal and a LO calibration signal. The former is used for down-converting the signal output from the antenna element under test for phase and amplitude measurement. The latter is used to compensate the quadrature mixer error in low-IF topology. The antenna signal amplitude and phase are extracted from the I/Q signals. This approach can compensate for most of the associated errors caused by nonlinearity of the quadrature modules and amplifiers using internal time-varying phase. A back-to-back measurement shows the proposed scheme can offer an accuracy of ±2 degrees in phase and ±0.3 dB in amplitude over a 30-dB dynamic range.
Distributed active transformer-a new power-combining and impedance-transformation technique (2002)

In this paper, we compare the performance of the newly introduced distributed active transformer (DAT) structure to that of conventional on-chip impedance-transformations methods. Their fundamental power-efficiency limitations in the design of high-power fully integrated amplifiers in standard silicon process technologies are analyzed. The DAT is demonstrated to be an efficient impedance-transformation and power-combining method, which combines several low-voltage push-pull amplifiers in series by magnetic coupling. To demonstrate the validity of the new concept, a 2.4-GHz 1.9-W 2-V fully integrated power-amplifier achieving a power-added efficiency of 41% with 50-/spl Omega/ input and output matching has been fabricated using 0.35-/spl mu/m CMOS transistors.
Temporal-filtering dissipative soliton in an optical parametric oscillator (2022)

Abstract Dissipative solitons have been realized in mode-locked fiber lasers in the theoretical framework of the Ginzburg–Landau equation and have significantly improved the pulse energy and peak power levels of such lasers. It is interesting to explore whether dissipative solitons exist in optical parametric oscillators in the framework of three-wave coupling equations in order to substantially increase the performance of optical parametric oscillators. Here, we demonstrate a temporal-filtering dissipative soliton in a synchronously pumped optical parametric oscillator. The temporal-gain filtering of the pump pulse combined with strong cascading nonlinearity and dispersion in the optical parametric oscillator enables the generation of a broad spectrum with a nearly linear chirp; consequently, a significantly compressed pulse and high peak power can be realized after dechirping outside the cavity. Furthermore, we realized, for the first time, dissipative solitons in an optical system with a negative nonlinear phase shift and anomalous dispersion, extending the parameter region of dissipative solitons. The findings may open a new research block for dissipative solitons and provide new opportunities for mid-infrared ultrafast science.
A 0.008mm<sup>2</sup> 2.4GHz type-I sub-sampling ring-oscillator-based phase-locked loop with a −239.7dB FoM and −64dBc reference spurs (2018)

A ring-oscillator (RO) based PLL is presented combining a type-I architecture and a sub-sampling phase detector (SSPD). It achieves low jitter thanks to the wide-bandwidth type-I loop and low reference spurs thanks to the SSPD with its sample-and-hold function and high gain. The integrating filter capacitor is avoided, resulting in very low area. The RO PLL prototype in 65nm CMOS occupies 0.008mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , has a loop bandwidth of 15MHz and tunes from 2 to 3.2GHz. It consumes 6.1mW at 2.4GHz with a phase noise of -122.6dBc/Hz at 1MHz offset. The measured reference spurs, RMSjitter and FoMjitter are -64.2dBc, 422fs and -239.7dB.
Population Analysis of Bacterial Samples for Individual Identification in Forensics Application (2013)

Biodefense preparedness begins with the ability to detect and respond to bio-threats, based on accurate interpretation of genetic information with sophisticated, yet easy-to-use bioinformatics tools. Microbial forensics further enables attribution of microbial pathogen samples back to a suspected source. Sample characterization and traceability back to source are dependent on genome identification of specific targets within samples, comprehensive analysis of mixtures of populations' present, and detection of major/minor variations in the identified genomes and comparison of sample genetic profile against other samples. Commercial Next Generation Sequencing (NGS) platforms offer the promise of dramatically higher detection sensitivity and resolution of forensic DNA samples than is possible with methods in current use. Before applying these technologies for forensic analyses of bacterial samples, however, it is critical to fully elucidate the benefits, caveats and pitfalls of NGS for hypothesis testing in comparative analyses, as ultimately this will be required for NGS use both as an investigative tool and tool for attribution in courts of law.
Radiation Pattern Synthesis for Monopulse Radar Applications With a Reconfigurable Transmitarray Antenna (2016)

We investigate here the capabilities of a 400-element reconfigurable transmitarray antenna to synthesize monopulse radiation patterns for radar applications in X-band. The generation of the sum (Σ) and difference (A) patterns are demonstrated both theoretically and experimentally for broadside as well as tilted beams in different azimuthal planes. Two different feed configurations have been considered, namely, a single focal source and a four-element focal source configuration. The latter enables the simultaneous generation of a Σ- and two A-patterns in orthogonal planes, which is an important advantage for tracking applications with stringent requirements in speed and accuracy.