gebhart/patrepeval huggingface dataset:
Vasoconstriction to Polymorphonuclear Leukocytes in the Isolated, Perfused Rabbit Heart: Inhibition by Prostacyclin Mimetics (1996)

Perfusion of the isolated rabbit heart with 5 x 10(6) human polymorphonuclear leukocytes (PMNL), under recirculating conditions (50 ml) and challenge with A-23187 (0.5 mu M) increased coronary perfusion pressure (CPP) sixfold, accompanied by increased levels of sulfidopeptide leukotrienes (CY-SLT), which had previously shown to correlate linearly with the increase in CPP. Pretreatment (20 min) of isolated rabbit hearts with the prostacyclin (PGI(2)) analogue iloprost (3 nM) resulted in significant protection against the increase in CPP and in almost complete inhibition of 5-lipoxygenase (5-LO) product synthesis. Similarly, pretreatment of isolated rabbit heart with defibrotide (200 mu g/ml), a polydeoxyribonucleotide derivative known to inhibit PMNL activation and enhance PGI(2) production by heart endothelial cells, produced significant protection against the increase in CPP and almost complete inhibition of 5-LO product synthesis. Neither iloprost nor defibrotide affected the A-23187-induced arachidonic acid (AA) metabolism in isolated PMNL alone. Inhibition of rabbit cyclooxygenase by intravenous (i.v.) administration of lysine-acetylsalicylate (60 mg/kg) 2 h before the animals were killed significantly reduced the protection provided by defibrotide, with a parallel fivefold increase in sulfidopeptide LT levels, returning to values in the range observed in control hearts. Control of endogenous modulators of leukocyte-vascular wall interactions such as PGI(2) results in significant changes in sulfidopeptide LT production in an organ model of transcellular metabolism of LT A(4), suggesting a novel mechanism of action for cardioprotective drugs in myocardial ischemia.
Electrobioleaching - A novel concept for processing complex sulphide ores (1998)

The role of applied DC potentials on mineral dissolution and growth of Thiobacillus ferrooxidans is illustrated with respect to possible mechanisms and applications in the bioleaching of complex multisulphides. Electrochemical principles governing mineral dissolution under electrobioleaching conditions are brought out. Electrobioleaching is shown to be advantageous with respect to selectivity in dissolution and enhanced yields of biomass. Applications in the treatment of multisulphide concentrates containing lead-zinc-copper are outlined with examples.
Vaccination against the human cytomegalovirus (2018)

The human cytomegalovirus (HCMV) is the most important infectious cause of congenital abnormalities and also of infectious complications of transplantation. The biology of the infection is complex and acquired immunity does not always prevent reinfection. Nevertheless, vaccine development is far advanced, with numerous candidate vaccines being tested, both live and inactivated. This article summarizes the status of the candidate vaccines.
Rapid isolation and detection of cancer cells by utilizing integrated microfluidic systems (2010)

The present study reports a new three-dimensional (3D) microfluidic platform capable of rapid isolation and detection of cancer cells from a large sample volume (e.g. ~1 mL) by utilizing magnetic microbead-based technologies. Several modules, including a 3D microfluidic incubator for the magnetic beads to capture cancer cells, a microfluidic control module for sample transportation and a nucleic acid amplification module for genetic identification, are integrated into this microsystem. With the incorporation of surface-modified magnetic beads, target cancer cells can be specifically recognized and conjugated onto the surface of the antibody-coated magnetic microbeads by utilizing a swirling effect generated by the new 3D microfluidic incubator, followed by isolating and purifying the magnetic complexes via the incorporation of an external magnet and a microfluidic control module, which washes away any unbound waste solution. Experimental results show that over 90% of the target cancer cells can be isolated from a large volume of bio-samples within 10 min in the 3D microfluidic incubator. In addition, the expressed genes associated with ovarian and lung cancer cells can also be successfully amplified by using the on-chip nucleic acid amplification module. More importantly, the detection limit of the developed system is found to be 5 × 10(1) cells mL(-1) for the target cancer cells, indicating that this proposed microfluidic system may be adapted for clinical use for the early detection of cancer cells. Consequently, the proposed 3D microfluidic system incorporated with immunomagnetic beads may provide a promising automated platform for the rapid isolation and detection of cancer cells with a high sensitivity.
Structural and Functional Evaluation of Modifications in the Composite Skin Graft (1992)

Structural and functional aspects of modifications in the composite skin graft consisting of cultured keratinocytes and cryopreserved dermis were determined. Cryopreserved human cadaveric dermis separated from skin by short and mild trypsinization was compared with dermis obtained by prolonged incubation in medium and with fresh dermis obtained by the same methods. All types of dermis were shown to retain normal ultrastructure and topographic organization, as detected by scanning and transmission electron microscope and immunofluorescence analysis. However, in fresh skin, the layers were more firmly attached, mechanical separation was more difficult, and residual epidermis often remained attached to the dermis. Keratinocytes attached better, began replication earlier, and generally reached higher cell numbers when cultured on trypsinized dermis than on medium-treated dermis. The performance of several modifications in the reconstitution and grafting procedures of the composite skin graft after transplantation to athymic mice was examined. Cultured epidermis combined onto trypsinized or medium-treated whole and meshed dermis, dermis pregrafted and allowed to take before transplanting epidermis on top, and keratinocytes grown into multiple epithelia on top of trypsinized meshed or whole dermis prior to grafting. The best grafting results were obtained with an "instant" reconstituted skin model: multiple epithelia grown in vitro combined immediately before grafting onto meshed trypsinized dermis. The transplantation results of this modification were significantly better than those of all the other modifications, including initial growth of keratinocytes into multiple epithelia on top of trypsinized dermis prior to grafting.
Investigation into the influence of organic modifiers and ultradispersed hybrid fillers on the structure and properties of glass-ceramic coatings prepared by the sol-gel method (2006)

Glass-ceramic coatings on nickel and its alloys are produced from organic-inorganic hybrids by the sol-gel method. The coatings are applied using sol-gel systems composed of tetraethoxysilane (inorganic dopant), as well as of finely dispersed oxide and ultradispersed hybrid fillers. Acrylic and methacrylic acid derivatives are taken as organic modifiers. Oligocarbonate dimethacrylate-substituted tetranuclear titanium oxide clusters are used as the ultradispersed hybrid filler. The influence of the organic modifiers and ultradispersed hybrid fillers on the physicochemical processes occurring in the sol-gel systems and on the electrical parameters of the coatings are experimentally studied, and the data obtained are analyzed.
Program development for a systolic array (1988)

The primary objective of the Warp programming environment (WPE) is to simplify the use of Warp, a high-performance programmable linear systolic array connected to a general-purpose workstation host. WPE permits the development of distributed applications that access Warp either locally from the host or remotely from a large number of workstations connected to a local area network. Its audience includes the user who calls routines from a library, the programmer who develops new algorithms for Warp, as well as the implementor who writes support software. Since the linear arrangement of the cells in the array restricts direct input and output with the host to the boundary cells, a source language debugger is important for program development on Warp. This paper presents the Warp debugger and its relation to the other components of the Warp programming environment.
Feature Article: Automatic Continuous Online Monitoring of Polymerization Reactions (ACOMP) (2004)

ACOMP provides an automatic, continuous means for absolute characterization of polymerization reactions in terms of monomer conversion, molecular weight, and other properties, without using chromatographic columns or injection loops [1]. The principle of ACOMP is to continuously withdraw a very small sample stream, typically 0.02 ml/minute from the reactor, and via an assembly of mixing pumps and chambers, provide a continuous stream of diluted material to a suitable detector train, typically comprising detectors for multi-angle light scattering, viscometry, differential refractometry, and ultraviolet/visible absorption. The dilution of the reactor contents is high enough that the characteristics of single polymer chains dominate the detected signals, allowing for absolute characterization based on model independent light scattering and concentration determinations. ACOMP has so far been used for free radical and controlled radical homo- and copolymerization, stepgrowth and branching reactions, in bulk and with solvent, and for batch and continuous reactors. Current efforts to expand ACOMP include heterogeneous phase reactions, such as in microemulsions, terpolymerization, and new living type reactions. This article reviews highlights of progress in this area.
Performance and Lyapunov Stability of a Nonlinear Path Following Guidance Method (2007)

Performance and stability are demonstrated for a nonlinear path-following guidance method for unmanned air vehicles. The method was adapted from a pure pursuit-based path following, which has been widely used in ground based robot applications. The method is known to approximate a proportional-derivative controller when following a straight line path, but it is shown that there is also an element of anticipatory control that enables tight tracking when following curved paths. Ground speed is incorporated into the computation of commanded lateral acceleration, which adds an adaptive capability to accommodate vehicle speed changes due to external disturbances such as wind. Asymptotic Lyapunov stability of the nonlinear guidance method is demonstrated when the unmanned air vehicle is following circular paths. The adaptive nature of the guidance method makes its stability independent of vehicle velocity. The stability analysis is also extended to show robust stability of the guidance law in the presence of saturated lateral acceleration, which is an inherent limitation of flight vehicles. Flight tests of the algorithm, using two small unmanned air vehicles, showed that each aircraft was controlled to within 1.6 m root mean square when following circular paths. The method was used to perform a rendezvous of the two aircraft, bringing them into very close proximity, within 12 m of along track separation and 1.4 m root mean square relative position errors.
A 60 GHz single-chip 256-element wafer-scale phased array with EIRP of 45 dBm using sub-reticle stitching (2015)

This paper presents a 60 GHz wafer-scale transmit phased-array with 256-elements spaced λ/2 apart in the x and y directions, and occupying an area of 4.14×4.2 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (1740 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). The phased array is built using independent RF, transmission-line and control circuit blocks which are stitched together to form an aggregate chip which is much larger than a standard reticle (22×22 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). This method allows for a wafer-scale design and can be extended to any size and any shape (rectangular, hexagonal, etc.) up to the edge of the wafer. The blocks include high-efficiency on-wafer antennas, phased-array channels with 3-bits amplitude and 5-bits phase control together with an amplifier having an output power of +3 dBm at 60 GHz. Also, a highly redundant RF distribution network is synthesized from several stitched blocks for improved yield, and the control blocks have redundant SPI control and power strips, also for improved yield. The 256-element array results in a half-power beamwidth of 6° in the E- and H-planes, a directivity of 29 dB, and scans to +/- 55° in the E- and H-planes with near-ideal patterns and a cross-polarization level of <;-25 dB. The measured EIRP is 45 dBm at 61 GHz and with a 3-dB bandwidth from 58 to 64 GHz. To our knowledge, this is the largest single-chip phased-array ever developed and allows the construction of large-scale (1000+ elements) phased-array systems, either on a single wafer or by assembling several of these chips together.
Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma (2000)

Histamine is involved in the pathophysiology of asthma, and histamine N-methyltransferase (HNMT) plays the dominant role in histamine metabolism in human bronchial epithelium. Levels of HNMT activity in human tissues are controlled, in part, by inheritance. A common C314T polymorphism within the HNMT gene results in a Thr105Ile change in encoded amino acid, and the T314 allele is associated with decreased levels of both HNMT enzymatic activity and immunoreactive protein. Therefore, presence of the T314 allele would be expected to result in reduced histamine metabolism and increased bronchoconstriction. We characterized this common, functionally significant polymorphism in DNA samples from 237 randomly selected Caucasian control subjects and 192 samples from Caucasian asthmatic patients. Allele frequencies for the T314 HNMT allele were 0.08 in the control samples and 0.14 in samples from Caucasian asthmatic patients (odds ratio = 1.9, P < 0.01), indicating a significant increase in the frequency of subjects with low HNMT activity among asthmatics. The association between a common, functionally significant genetic polymorphism for HNMT and asthma suggests that individual variation in histamine metabolism might contribute to the pathophysiology and/or response to therapy of this disease.
Microarray-Based Identification of <i>Tenascin C</i> and <i>Tenascin XB</i> , Genes Possibly Involved in Tumorigenesis Associated with Neurofibromatosis Type 1 (2007)

TNXB and TNC may be involved in the malignant transformation of plexiform neurofibromas. Anti-TNC antibodies, already used successfully in clinical trials to treat malignant human gliomas, may be an appropriate new therapeutic strategy for NF1.
Pravas Sarthi - A Convenience: MultiLingual Virtual Assistant (2019)

Travelling is a necessity nowadays since it breaks the monotony of life and work. Life, for many, has become a mad rush to such an extent that they have forgotten the essence of life. Travelling gives this very essence back to the people. Meeting new people, getting to know different cultures, visiting new places brings a level of peace to one's mind. But, people are more comfortable communicating in their own language when they feel perplexed in an alien area. This paper thus proposes a system that would ease travellers journey by helping them communicate in their native language. The proposes a novel rule-based algorithm which will extract the feature words from the sentence spoken by the user, performs preprocessing using Natural Language Processing(NLP) and based on some predefined rules, it will display the response to the query asked by the user. This paper thereby focuses on the societal benefits of all travelers in an airport with a language friendly system to make their travel comfortable across different cultures and backgrounds.
MicroRNA‐23b cluster microRNAs regulate transforming growth factor‐beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads† (2009)

Our data provide a model in which miR-23b miRNAs repress bile duct gene expression in fetal hepatocytes while promoting their growth by down-regulating Smads and consequently TGFbeta signaling. Concomitantly, low levels of the miR-23b miRNAs are needed in cholangiocytes to allow TGFbeta signaling and bile duct formation.
Cloning, Expression, and Functional Characterization of the β Regulatory Subunit of Human Methionine Adenosyltransferase (MAT II) (2000)

MAT II, the extrahepatic form of methionine adenosyltransferase (MAT), consists of catalytic alpha(2)/alpha(2') subunits and a noncatalytic beta subunit, believed to have a regulatory function. The full-length cDNA that encodes the beta subunit of human MAT II was cloned and found to encode for a 334-amino acid protein with a calculated molecular weight of 37,552. Analysis of sequence homology showed similarity with bacterial enzymes that catalyze the reduction of TDP-linked sugars. The beta subunit cDNA was cloned into the pQE-30 expression vector, and the recombinant His tagged protein, which was expressed in Escherichia coli, was recognized by antibodies to the human MAT II, to synthetic peptides copying the sequence of native beta subunit protein, and to the rbeta protein. There is no cross-reactivity between the MAT II alpha(2) or beta subunits. None of the anti-beta subunit antibodies reacted with protein extracts of E. coli host cells, suggesting that these bacteria have no beta subunit protein. Interestingly, the rbeta subunit associated with E. coli as well as human MAT alpha subunits. This association changed the kinetic properties of both enzymes and lowered the K(m) of MAT for L-methionine. Together, the data show that we have cloned and expressed the human MAT II beta subunit and confirmed its long suspected regulatory function. This knowledge affords a molecular means by which MAT activity and consequently the levels of AdoMet may be modulated in mammalian cells.
Prolongation of lidocaine spinal anesthesia with phenylephrine. (1986)

The effect of added phenylephrine on the duration of sensory analgesia during lidocaine spinal anesthesia was determined in 65 ASA class I-III patients randomly divided into three groups. Group 1 (n = 25) received 62.5 mg lidocaine in 7.5% glucose; group 2 (n = 21) received lidocaine with 2 mg phenylephrine; and group 3 (n = 19) received lidocaine with 5 mg phenylephrine. The level of analgesia to pin prick was assessed by an anesthesiologist unaware of the drug combination used. The mean +/- SD cephalad level of analgesia did not differ among the groups. In group 1, the times for two- and for four-segment regression of the level of analgesia, and the time for regression of analgesia to the T-12 dermatome, were 77 +/- 19 (1 SD), 99 +/- 24, and 109 +/- 26 min, respectively. The corresponding values were 98 +/- 25, 118 +/- 27, and 130 +/- 36 min in group 2 and 124 +/- 32, 142 +/- 31, and 162 +/- 35 min in group 3. All the regression times in group 2 were significantly longer than those in group 1 (P less than 0.05). All the regression times in group 3 were significantly longer than those in group 2 (P less than 0.02). It is concluded that clinically useful prolongation of sensory analgesia may be obtained by addition of phenylephrine to lidocaine during spinal anesthesia.
Talking about Yourself (1997)

Before you start, do read the introduction to the course on p. iv. This gives advice on studying alone and explains the study pattern suggested for this course. Breakthrough French will try to develop your ability to follow the gist of spoken French right from the start, so begin by listening to the first group of conversations on the recording without looking at your book. When you have listened to the conversations, you can look at the transcript of them in the book and read the notes explaining the language used. It is a good idea to listen to the conversations several times before you go on to the exercises in the Practice sections.
Inventing the networked home (2000)

article Free Access Share on Inventing the networked home: Sun, 3 Com, and other companies share their visions of the future at CES Author: Brent Butterworth etown.com etown.comView Profile Authors Info & Claims netWorkerVolume 4Issue 1March 2000 pp 20–25https://doi.org/10.1145/330894.330898Published:01 March 2000Publication History 0citation523DownloadsMetricsTotal Citations0Total Downloads523Last 12 Months6Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Quantum anti-Zeno effect (1997)

Prevention of a quantum system's time evolution by repetitive, frequent measurements of the system's state has been called the quantum Zeno effect (or paradox). Here we investigate theoretically and numerically the effect of repeated measurements on the quantum dynamics of multilevel systems that exhibit the quantum localization of classical chaos. The analysis is based on the wave function and Schr\"odinger equation, without introduction of the density matrix. We show how the quantum Zeno effect in simple few-level systems can be recovered and understood by formal modeling the effect of measurement on the dynamics by randomizing the phases of the measured states. This analysis is extended to investigate the dynamics of multilevel systems driven by an intense external force and affected by frequent measurements. We show that frequent measurements of such quantum systems results in delocalization of the quantum suppression of classical chaos. This result is the opposite of the quantum Zeno effect. The phenomenon of delocalization of the quantum suppression and restoration of quasi-classical time evolution of these systems, owing to repetitive frequent measurements, can therefore be called the quantum anti-Zeno effect. From this analysis we furthermore conclude that frequently or continuously observable quasiclassical systems evolve basically in a classical manner.
From Markov Chains to Compartmental Models (1999)

For our Markov chain models, we have always assumed that the state vectors are probabilities. However, in some applications such as ecosystems, we are more interested in the quantities of, say, a nutrient in a particular state at a particular time rather than the probability that a molecule is in that state at that time. We shall see that the two concepts are equivalent.