gebhart/patrepeval huggingface dataset:
Low temperature synthesis of phosphorous and nitrogen co-doped yellow fluorescent carbon dots for sensing and bioimaging (2015)

Phosphorous and nitrogen co-doped carbon dots (P,N-CDs) with satisfactory quantum yield have been prepared through one-step acidic oxidation of pumpkin by H<sub>3</sub>PO<sub>4</sub> at low temperature (90 °C). The as-prepared P,N-CD is relatively monodisperse with a narrow size distribution. The P,N-CD displays a remarkable emission enhancement in the yellow fluorescence region (λ<sub>em</sub> = 550 nm) when the pH is increased from 1.5 to 7.4. The pK<sub>a</sub> value of P,N-CDs was found to be 4.17 and it shows linear response to the physiological range of pH 4.7-7.4, which is valuable for near-neutral cytosolic pH research. It is observed that P,N-CDs are superior fluorescent bioimaging agents in animals and cells thanks to their excellent solubility and ultra-low toxicity. In addition, P,N-CDs display a notably large Stokes shift of 125 nm, good reversibility and could effectively avoid the influence of autofluorescence in biological systems. The confocal fluorescent microscopic images of subcellular distribution and the detection of pH in MCF-7 cells were achieved successfully, suggesting that P,N-CDs have excellent cell membrane permeability and are further applied successfully to monitor pH fluctuations in live cells with negligible autofluorescence.
Camera working parameter extraction for constructing video considering camera shake (2002)

With the increasing popularity of high-performance DV cameras and video editing applications on PC, desktop videos have become more attractive. Video editing and summary, however, still poses problems as it lacks useful support tools, which can efficiently show the video contents to editors. Against this background, our goal is to build a useful video-editing system grounded on techniques of content analysis. On the basis of our video document architecture concept, we regard camera work parameters as a means of reference to construct video. Camera work parameters can be defined follows: (1) a variety of camera work patterns (such as panning and zooming, etc.); and (2) the quality of camera work of speed and camera shake rate. By calculating these parameters, we aim to build a system, enabling one to detect significant scene candidates from the original shot sequence as well as edit videos automatically.
A multisensor detector of a sleep apnea for using at home (2013)

Diagnosis of obstructive sleep apnea usually involves polysomnographic analysis, which unfortunately requires overnight stay in a specialized clinic and is very uncomfortable for a patient. This paper describes the method and apparatus for recording a set of signals to detect sleep apnea. The device records the following signals simultaneously: three-channel ECG, respiratory functions, signals from the accelerometer, and snoring sounds. Measurements are carried out during the night, in the patient's home. Algorithm for automatic analysis of the data can be used to detect sleep apnea and hypopnea.
Effect of supplementation with chokeberry juice on the inflammatory status and markers of iron metabolism in rowers (2014)

Supplementation with chokeberry juice results in an increase in the antioxidant activity of plasma and contributes significantly to reducing the TNF-alpha level.
Systemic effects of phytoecdysteroids on the cabbage aphid Brevicoryne brassicae (Sternorrhyncha: Aphididae) (2005)

The systemic effects of phytoecdysteroids were investigated by applying tested compounds to the roots of the rape plants. Evaluation of the effects was based on mortality, longevity, rate of development and fecundity of the cabbage aphid (Brevicoryne brassicae L., Sternorrhyncha: Aphididae) feeding on the shoot of the treated plants. The major ecdysteroid compounds tested were natural products isolated from a medicinal plant Leuzea carthamoides DC (Willd.) Iljin (Asteraceae): 20-hydroxyecdysone (20E), ajugasterone C (ajuC) and polypodine B (polyB). The compounds were tested in two concentrations (0.07 and 0.007 mg/ml) in water. In addition, we have also investigated the systemic effects of a special Lc-Ecdy 8 fraction isolated from L. carthamoides, which contained 20E, ajuC and polyB and at least six other minor compounds in addition to the above indicated ecdysteroids. HPLC analysis of the Lc-Ecdy 8 fraction indicated the presence of makisterone A and inokosterone in minor quantities. It appeared that all ecdysteroid compounds tested, with the exception of the most common, 20E, decreased the fecundity of cabbage aphids which fed on the contaminated rape plants. The mortality of larvae and adults significantly increased on plants treated with the Lc-Ecdy 8 fraction, and with ajuC or polyB compounds containing structural substituents in rather unusual positions. The most common phytoecdysteroid, 20E, with the typical and characteristic ecdysteroid structure, was the best tolerated of all phytoecdysteroids tested.
When Will You Answer This? Estimating Response Time in Twitter (2021)

We present a study analyzing the response times of users to questions on Twitter. We investigate estimating these response times using an exponential distribution-based wait time model learned from users’ previous responses. Our analysis considers several different model building approaches, including personalized models for each user, general models built for all users, and time-sensitive models specific to a day of the week or hour of the day. Our evaluation using a real world question-answer dataset shows the effectiveness of our approach.
<i>N</i> -glycan profiling of bovine follicular fluid at key dominant follicle developmental stages (2014)

Follicular fluid (FF), an important microenvironment for the development of oocytes, contains many proteins that are glycosylated with N-linked glycans. This study aimed i) to present an initial analysis of the N-linked glycan profile of bovine FF using hydrophilic interaction liquid chromatography, anion exchange chromatography, high performance liquid chromatography (HPLC)-based separations and subsequent liquid chromatography-mass spectrometry/mass spectrometry analysis; ii) to determine differences in the N-glycan profile between FF from dominant and subordinate follicles from dairy heifers and lactating dairy cows and iii) to identify alterations in the N-glycan profile of FF during preovulatory follicle development using newly selected, differentiated (preovulatory) and luteinised dominant follicles from dairy heifers and lactating cows. We found that the majority of glycans on bovine FF are based on biantennary hypersialylated structures, where the glycans are sialylated on both the galactose and N-acetylglucosamine terminal sugars. A comparison of FF N-glycans from cows and heifers indicated higher levels of nonsialylated glycans with a lower proportion of sialylated glycans in cows than in heifers. Overall, as the follicle develops from Selection, Differentiation and Luteinisation in both cows and heifers, there is an overall decrease in sialylated structures on FF N-glycans.
Tyr‐426 of the <i>Escherichia coli</i> asparaginyl‐tRNA synthetase, an amino acid in a C‐terminal concerved motif, is involved in ATP binding (1991)

Sequence comparisons of the E. coli asparaginyl-tRNA synthetase (NRSEC) with aminocyl-tRNA synthetase sequences of class II enzymes show significant homologies with aspartyl- and lysyl-tRNA synthetases. Three conserved regions were found, one of which is located in the C-terminal part of the NRSEC sequence. Site-directed mutagenesis was performed in this conserved region. A single point mutation Tyr-426----Ser results in a 15-fold increase in the Km for ATP, while all the other kinetic parameters remain unchanged. The replacement of this Tyr-426 by a Phe does not affect the kinetic behaviour of the enzyme. These data indicate that Tyr-426 is part of the ATP binding site.
Romantische Lyrik (2001)

In Achim von Arnims 1802 erschienenem Roman Hollin’s Liebesleben findet sich eine Passage, die eine Perspektive auf romantische Lyrik ermöglicht. Gemeinsam mit einer Reisegruppe befinden sich der Held und seine Geliebte auf einem exponierten Ort im Gebirge. Sie fühlen sich gleichermaßen abgestoßen und belustigt durch ein »Gedicht in Hexametern«, das ein mitreisender Poet alter Schule »während des Sonnenaufgangs auf den Sonnenaufgang in seine Schreibtafel gedichtet« (Arnim I, 41) hat. Arnim führt exemplarisch vor Augen, was sich am besten mit einem »hexametrischen Sonnengedicht« anfangen läßt, »das Stück für Stück eine genaue Abschilderung dieses herrlichen Naturphänomens« (ebd., 42) ist: Er läßt den Morgenwind dafür sorgen, daß das Papier, auf dem das Gedicht geschrieben ist, auf Nimmerwiedersehen verschwindet und gleichsam in Natur zurückverwandelt wird. Daß das frühromantische Liebespaar gegen eine Lyrik der Naturnachahmung auf einer Poesie der Imagination und Phantasie besteht, deutet Arnim an, wenn Tiecks »Magelone« (ebd., 41) zum Requisit eines geheimen Einverständnisses zwischen den Liebenden wird. Im Gesprächsrahmen von Tiecks Phantasus (1812) erfährt Arnim eine späte Bestätigung. Tiecks fiktive Gesprächsteilnehmer machen sich über »Naturjäger« lustig, die »auf Sonnen-Auf- und Untergänge von hohen Bergen, auf Wasserfälle und Naturphänomene wahrhaft Jagd machen« (Tieck VI, 111). Und ähnlich wie Arnims Liebespaar hält man es mit demjenigen Dichter, »welcher nicht nachahmt, sondern zum erstenmal ein Ding vorträgt, welches unsre Imagination ergreift« (ebd., 147).
Synthesis, Characterization, and Reactivity of Multinuclear Zinc(II) Alkyl Derivatives of Linked Phenoxides (2001)

Alkyl zinc derivatives of tris(3,5-dialkyl-2-hydroxyphenyl)methanes (alkyl = tert-butyl 1a, methyl 1b, tert-pentyl 1c) have been prepared by reaction with dimethyl or diethylzinc, and characterized. Whereas dimethylzinc with 1a or diethylzinc with 1b give S6 symmetric, hexanuclear aggregates with the general formula 12(ZnR)6 (R = Me 2a, Et 2b), when 1a reacts with diethylzinc, solvent dependent reactions take place. If dichloromethane is used for the reaction solvent, a dimeric, C2 symmetric, tetranuclear product with the formula 1a2Zn2(ZnEt)2 (3) is isolated while in diethyl ether, a C2 symmetric, pentanuclear aggregate 1a2Zn(ZnEt)4 (4) forms, and in tetrahydrofuran a C3 symmetric trinuclear compound 1a[ZnEt(THF)]3 (5a) is produced. Each example is represented by a single-crystal X-ray structure determination. Preliminary studies regarding their activity toward the copolymerization of cyclohexene oxide and carbon dioxide are also reported.
On-line dilution scheme for liquid chromatography (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn-line dilution scheme for liquid chromatographyJavier N. Oquendo and Joseph A. LeoneCite this: Anal. Chem. 1989, 61, 15, 1791–1792Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ac00190a042https://doi.org/10.1021/ac00190a042research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Kernel MSE algorithm: a unified framework for KFD, LS-SVM and KRR (2002)

We generalize the conventional minimum squared error (MSE) method to yield a new nonlinear learning machine by using the kernel idea and adding different regularization terms. We name it kernel minimum squared error (KMSE) algorithm, which can deal with linear and nonlinear classification and regression problems. With proper choices of the output coding schemes and regularization terms, we prove that KMSE is identical to the kernel Fisher discriminant (KFD) except for an unimportant scale factor, and it is directly equivalent to the least square version for support vector machine (LS-SVM). For continuous real output values, we find that KMSE is the kernel ridge regression (KRR) with a bias. Therefore KMSE can act as a general framework that includes KFD, LS-SVM and KRR as its particular cases. In addition, we simplify the formula to estimate the projecting direction of KFD. Experiments on artificial and real world data sets in numerical computation aspects demonstrate that KMSE is a class of powerful kernel learning machines.
Identification, distribution, and sequence analysis of new insertion elements in Caulobacter crescentus (1990)

We describe two insertion elements isolated from Caulobacter crescentus that are designated IS298 and IS511. These insertion elements were cloned from spontaneous flagellar (fla) gene mutants SC298 and SC511 derived from the wild-type strain CB15 (ATCC 19089), in which they were originally identified as insertions in the flbG operon of the hook gene cluster (N. Ohta, E. Swanson, B. Ely, and A. Newton, J. Bacteriol. 158:897-904, 1984). IS298 and IS511 were each present in C. crescentus CB2 and CB15 in at least four different positions, but neither was present in strain CB13 or in several Caulobacter species examined, including C. vibrioides, C. leidyia, and C. henricii. Nucleotide sequence analysis across the chromosome-insertion element junctions showed that IS298 is located 152 base pairs (bp) upstream from the ATG translation start of the hook protein gene flaK, where it is bounded by a 4-bp direct repeat derived from the site of insertion, and that IS511 is inserted at codon 186 of the flaK coding sequence, where it is also bounded by a 4-bp direct repeat duplicated from the site of insertion. The ilvB102 mutation in strain SC125 was also shown to result from insertion sequence IS511, but no duplication of the genomic sequence was present at the insertion element junctions. IS298 contains an imperfect terminal inverted repeat 16 bp long, and IS511 contains a 32-bp inverted repeat at the termini. IS298 and IS511 are the first insertion elements described in C. crescentus.
An Integrated New Scheme for Digital Video Stabilization (2013)

In many digital video applications, video sequences suffer from jerky movements between successive frames. In this paper, an integrated general-purpose stabilization method is proposed, which extracts the information from successive frames and removes the translation and rotation motions that result in undesirable effects. The scheme proposed starts with computation of the optical flow between consecutive video frames and an affine motion model is adopted in conjunction with the optical flow field obtained to estimate objects or camera motions using the Horn-Schunck algorithm. The estimated motion vectors are then used by a model-fitting filter to stabilize and smooth video sequences. Experimental results demonstrate that the proposed scheme is efficient due to its simplicity and provides good visual quality in terms of the global transformation fidelity measured by the peak-signal-noise-ratio.
Heterotopic ossification of tendon and ligament (2020)

Much of the similarities of the tissue characteristics, pathologies and mechanisms of heterotopic ossification (HO) formation are shared between HO of tendon and ligament (HOTL). Unmet need and no effective treatment has been developed for HOTL, primarily attributable to poor understanding of cellular and molecular mechanisms. HOTL forms via endochondral ossification, a common process of most kinds of HO. HOTL is a dynamic pathologic process that includes trauma/injury, inflammation, mesenchymal stromal cell (MSC) recruitment, chondrogenic differentiation and, finally, ossification. A variety of signal pathways involve HOTL with multiple roles in different stages of HO formation, and here in this review, we summarize the progress and provide an up-to-date understanding of HOTL.
Lithium-ion cell technology demonstration for future NASA applications (2005)

NASA requires lightweight rechargeable batteries for future missions to Mars and the outer planets that are capable of operating over a wide range of temperatures, with high specific energy and energy densities. Due to their attractive performance characteristics, lithium-ion (Li-ion) batteries have been identified as the battery chemistry of choice for a number of future applications, including planetary orbiters, rovers and landers. For example, under the Mars Surveyor Program M5P 01 lithium-ion batteries were developed by Lithion (each being 28 V, 25 Ah, 8-cells, and 9 kg) and fully qualified prior to mission cancellation. In addition to the requirement of being able to supply at least 90 cycles on the surface of Mars, the battery demonstrated operational capability (both charge and discharge) over a large temperature range (-20/spl deg/C to +40/spl deg/C), with tolerance to nonoperational excursions to -30/spl deg/C and 50/spl deg/C. Currently, JPL is implementing lithium-ion technology on the 2003 Mars Exploration Rover (MER), which will be coupled with a solar array. This mission has similar performance requirements to that of the 2001 Lander in that high energy density and a wide operating temperature range are necessitated. In addition to planetary rover and lander applications, we are also engaged in determining the viability of using lithium-ion technology for orbiter applications that require exceptionally long life (/spl deg/20,000 cycles at partial depth of discharge). To assess the viability of lithium-ion cells for these applications, a number of performance characterization tests have been performed (at the cell and battery level) on state-of-art prototype lithium-ion cells, including: assessing the cycle life performance (at varying DODs), life characteristics at extreme temperatures (+40/spl deg/C), rate capability as a function of temperature (-30/spl deg/C to 40/spl deg/C), pulse capability, self-discharge and storage characteristics, as well as, mission profile capability. This paper will describe the current and future NASA missions that are considering lithium (Li) ion batteries and will contain results of the cell testing conducted to-date to validate the technology for these missions.
Demonstration of Cross-Protective Vaccine Immunity against an Emerging Pathogenic Ebolavirus Species (2010)

A major challenge in developing vaccines for emerging pathogens is their continued evolution and ability to escape human immunity. Therefore, an important goal of vaccine research is to advance vaccine candidates with sufficient breadth to respond to new outbreaks of previously undetected viruses. Ebolavirus (EBOV) vaccines have demonstrated protection against EBOV infection in nonhuman primates (NHP) and show promise in human clinical trials but immune protection occurs only with vaccines whose antigens are matched to the infectious challenge species. A 2007 hemorrhagic fever outbreak in Uganda demonstrated the existence of a new EBOV species, Bundibugyo (BEBOV), that differed from viruses covered by current vaccine candidates by up to 43% in genome sequence. To address the question of whether cross-protective immunity can be generated against this novel species, cynomolgus macaques were immunized with DNA/rAd5 vaccines expressing ZEBOV and SEBOV glycoprotein (GP) prior to lethal challenge with BEBOV. Vaccinated subjects developed robust, antigen-specific humoral and cellular immune responses against the GP from ZEBOV as well as cellular immunity against BEBOV GP, and immunized macaques were uniformly protected against lethal challenge with BEBOV. This report provides the first demonstration of vaccine-induced protective immunity against challenge with a heterologous EBOV species, and shows that Ebola vaccines capable of eliciting potent cellular immunity may provide the best strategy for eliciting cross-protection against newly emerging heterologous EBOV species.
European guideline for the diagnosis and treatment of insomnia (2017)

This European guideline for the diagnosis and treatment of insomnia was developed by a task force of the European Sleep Research Society, with the aim of providing clinical recommendations for the management of adult patients with insomnia. The guideline is based on a systematic review of relevant meta-analyses published till June 2016. The target audience for this guideline includes all clinicians involved in the management of insomnia, and the target patient population includes adults with chronic insomnia disorder. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) system was used to grade the evidence and guide recommendations. The diagnostic procedure for insomnia, and its co-morbidities, should include a clinical interview consisting of a sleep history (sleep habits, sleep environment, work schedules, circadian factors), the use of sleep questionnaires and sleep diaries, questions about somatic and mental health, a physical examination and additional measures if indicated (i.e. blood tests, electrocardiogram, electroencephalogram; strong recommendation, moderate- to high-quality evidence). Polysomnography can be used to evaluate other sleep disorders if suspected (i.e. periodic limb movement disorder, sleep-related breathing disorders), in treatment-resistant insomnia, for professional at-risk populations and when substantial sleep state misperception is suspected (strong recommendation, high-quality evidence). Cognitive behavioural therapy for insomnia is recommended as the first-line treatment for chronic insomnia in adults of any age (strong recommendation, high-quality evidence). A pharmacological intervention can be offered if cognitive behavioural therapy for insomnia is not sufficiently effective or not available. Benzodiazepines, benzodiazepine receptor agonists and some antidepressants are effective in the short-term treatment of insomnia (≤4 weeks; weak recommendation, moderate-quality evidence). Antihistamines, antipsychotics, melatonin and phytotherapeutics are not recommended for insomnia treatment (strong to weak recommendations, low- to very-low-quality evidence). Light therapy and exercise need to be further evaluated to judge their usefulness in the treatment of insomnia (weak recommendation, low-quality evidence). Complementary and alternative treatments (e.g. homeopathy, acupuncture) are not recommended for insomnia treatment (weak recommendation, very-low-quality evidence).