gebhart/patrepeval huggingface dataset:
A cloud-powered driver-less printing system for smartphones (2013)

Smart devices such as smartphones and tablets are becoming more powerful and versatile enough to replace conventional personal computers. Despite the rapid evolution in their capabilities, controlling peripherals such as network printers directly from smart devices is still in the primitive stage due to the lack of dedicated drivers. We propose and prototype a cloud-powered, driver-less printing system called CloudBridge for ubiquitous printing support from off the shelf smart devices. The CloudBridge service, which runs on a smart device, operates as a communication bridge connecting a network printer and a cloud server. By using cloud's ability to translate the operation commands into a language that the printer can understand, it is possible for a smart device to control the printer without having dedicated drivers. CloudBridge achieves the true meaning of ubiquitous mobile printing: it does not require any prerequisite settings. Compared to most widely used mobile printing solutions, the operation time is reasonable, compensating for the time and effort required for setting up the solution. CloudBridge is further optimized to improve the quality of experience, such as response time and energy consumption of the smart device, by adopting an adaptive compression method.
Gas-phase thermodynamic models of nitrogen-induced nanocrystallinity in chemical vapor-deposited diamond (2002)

Gas-phase thermodynamic equilibrium calculations involving H2/CH4/N2 mixtures were performed to investigate the chemical interactions leading to nitrogen-induced nanocrystallinity in microwave plasma chemical vapor deposition of diamond films. The strong influence of the CN radical in causing nanocrystallinity is confirmed by the correlation of its modeled composition in the gas phase with the degree of nanocrystallinity as determined experimentally for diamond films grown with different N2 additions. For a given CH4 feedgas concentration, there exists a critical N2 feedgas concentration, above which the change in the CH3/CN ratio is minimal and further induced nanocrystallinity is diminished. This is verified experimentally where it is observed that the same critical N2 feedgas concentration exists, above which a further decrease in diamond crystallinity and surface roughness of the grown diamond films is minimal.
Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development (1998)

The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events.
The whole-spacecraft vibration isolation system - Its time has come (1999)

Spacecraft typically are hard-mounted to the lau,nch vehicle for launch. Therefore, all of the high dynamic loads from the launch are transmitted directly from the launch vehicle to the spacecraft. The launch events include lift-off, motor excitation, buffet, staging and fairing separation, etc. A whole-spacecraft vibration isolation ' system is an isolation system that vibration-isolates the complete spacecraft from the launch vehicle. Unlike many typical isolation systems, this isolation system must couple two dynamically rich structures in the same frequency range as the individual components. Therefore, a coupled-loads approach must be used for its design characteristics. This paper discusses two whole-spacecraft systems: a shear-type designed for a large, liquid-fueled vehicle, and an axial system, designed for small, solid-fueled launch vehicles. A prototype shear-type of system was designed, built and tested for a Delta II class of launch vehicle. Coupled-loads analyses predicted that the RMS lateral accelerations on the spacecraft were reduced by a factor of two to six. The axial-type of system has been flown on two flights: the Taurus/GFO and the Taurus/STEX. Flight data shows that the dynamic responses on the spacecraft were reduced by up to a factor of 5.
Synthesis of (6-/sup 3/H)-1. cap alpha. -hydroxyvitamin D/sub 3/ and its metabolism in vivo to (/sup 3/H)-1,25-dihydroxyvitamin D/sub 3/. [Rats] (1975)

(6-/sup 3/H)-1..cap alpha..-Hydroxyvitamin D/sub 3/ was chemically synthesized and its full biological activity and radiochemical purity were demonstrated. With the use of this preparation it has been possible to demonstrate in vivo that in rats the (6-/sup 3/H)-1..cap alpha..-hydroxyvitamin D/sub 3/ is converted to (6-/sup 3/H)-1..cap alpha..,25-dihydroxyvitamin D/sub 3/, the natural hormone. In fact, in the intestine and bone of rats given 32 picomoles of (6-/sup 3/H)-1..cap alpha..-hydroxyvitamin D/sub 3/ each day for 6 days, more than 80 percent of the lipid-soluble radioactivity exists as (6-/sup 3/H)-1..cap alpha..,25-dihydroxyvitamin D/sub 3/, a finding that suggests that much of the biological effectiveness of 1..cap alpha..-hydroxyvitamin D/sub 3/ is due to its conversion to 1..cap alpha..,25-dihydroxyvitamin D/sub 3/.
8 Transgenetic Investigations of the Species Barrier and Prion Strains (1999)

The history of prion strains started in 1936, with the first reported claim by Cuille and Chelle (1939) of the successful transmission of scrapie by intraocular injection of healthy sheep with spinal cord from an afflicted sheep. This milestone event provided the first evidence that the disease was transmissible and led inevitably to a search for the infectious agent responsible. At first, the logical conclusion was that it must be a virus. Because of the extended incubation times, these diseases were often referred to as either slow virus diseases or unconventional viral diseases (Sigurdsson 1954; Gajdusek 1977, 1985). As detailed in other chapters in this book, considerable effort was expended searching for the “scrapie virus”; yet, nothing was found either with respect to a virus-like particle or a genome composed of RNA or DNA. Over the ensuing period of more than 60 years, it has become clear that scrapie is only one of a growing number of diseases known to be caused by prions and that prions comprise a unique class of pathogens that multiply by an entirely novel mechanism (Prusiner 1982a). In this study, we focus on the mechanisms that determine susceptibility to prions, that support prion diversity, and that govern the emergence of distinct prion strains during serial transmission. EVIDENCE AGAINST A CONVENTIONAL GENOME Aficionados of the virus hypothesis were challenged by a large body of evidence showing that the agent had properties unlike any known virus. The infectious agent showed a remarkable resistance to treatments, such as...
Formation and characterization of a new monoclinic lithium manganese oxide: m-type LixMnO2 (1997)

A new lithium manganese oxide with formula LixMnO2 (x = 0.20.3), denoted as m-phase, has been identified and isolated. First noticed as an intermediate phase during the early steps of the solid-state synthesis of Li–Mn–O spinels at low temperature, it can be isolated by extended annealing and grinding mixtures of finely divided β-MnO2 and LiOH or Li2CO3 at 150 °C. Its X-ray pattern can be indexed as primitive monoclinic with a = 938, b = 565.5, c = 490.6 pm and β = 102.2 °. Thermogravimetric and X-ray investigations show that it is stable up to ca. 550 °C. The m-phase structure appears to be rather rigid. It allows only limited lithium extraction in acidic medium and limited electrochemical lithium intercalation, with maximum reversible capacity Δx = 0.25 Li per formula unit. These properties confirm that it is a new oxide, with a rather different behaviour from that of known spinel-type or layered Li–Mn–O compounds.
Accurate cell counts in live mouse embryos using optical quadrature and differential interference contrast microscopy (2006)

Present imaging techniques used in in vitro fertilization (IVF) clinics are unable to produce accurate cell counts in developing embryos past the eight-cell stage. We have developed a method that has produced accurate cell counts in live mouse embryos ranging from 13-25 cells by combining Differential Interference Contrast (DIC) and Optical Quadrature Microscopy. Optical Quadrature Microscopy is an interferometric imaging modality that measures the amplitude and phase of the signal beam that travels through the embryo. The phase is transformed into an image of optical path length difference, which is used to determine the maximum optical path length deviation of a single cell. DIC microscopy gives distinct cell boundaries for cells within the focal plane when other cells do not lie in the path to the objective. Fitting an ellipse to the boundary of a single cell in the DIC image and combining it with the maximum optical path length deviation of a single cell creates an ellipsoidal model cell of optical path length deviation. Subtracting the model cell from the Optical Quadrature image will either show the optical path length deviation of the culture medium or reveal another cell underneath. Once all the boundaries are used in the DIC image, the subtracted Optical Quadrature image is analyzed to determine the cell boundaries of the remaining cells. The final cell count is produced when no more cells can be subtracted. We have produced exact cell counts on 5 samples, which have been validated by Epi-Fluorescence images of Hoechst stained nuclei.
Multi-channel signal separation by decorrelation (1993)

Identification of an unknown system and recovery of the input signals from observations of the outputs of an unknown multiple-input, multiple-output linear system are considered. Attention is focused on the two-channel case, in which the outputs of a 2*2 linear time invariant system are observed. The approach consists of reconstructing the input signals by assuming that they are statistically uncorrelated and imposing this constraint on the signal estimates. In order to restrict the set of solutions, additional information on the true signal generation and/or on the form of the coupling systems is incorporated. Specific algorithms are developed and tested. As a special case, these algorithms suggest a potentially interesting modification of Widrow's (1975) least-squares method for noise cancellation, where the reference signal contains a component of the desired signal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optical phaselock receiver with multigigahertz signal bandwidth (1989)

We have built a balanced pin FET receiver which employs two signal amplification paths for homodyne detection of multigigabit-per-second, pilot-carrier PSK optical signals. Using narrow-line 1.51µm semiconductor lasers, we have employed this receiver to phaselock a local oscillator to a 295 pW pilot carrier with 8° RMS phase error.
Semisynthesis of Ingenol 3-Angelate (PEP005): Efficient Stereoconservative Angeloylation of Alcohols (2012)

A high-yielding method was developed for the preparation of ingenol 3-angelate (PEP005, ingenol mebutate) via the corresponding 5,20-acetonide without concomitant isomerization of the angelate (<i>Z</i>-form) to the corresponding tiglate (<i>E</i>-form). The general scope of the stereoconservative esterification method was further evaluated on several different alcohols, giving the angelates in up to quantitative yield without isomerization to the tiglate.
2D to 3D Line-Based Registration with Unknown Associations via Mixed-Integer Programming (2020)

Determining the rigid-body transformation be-tween 2D image data and 3D point cloud data has applications for mobile robotics including sensor calibration and localizing into a prior map. Common approaches to 2D-3D registration use least-squares solvers assuming known associations often provided by heuristic front-ends, or iterative nearest-neighbor. We present a linear line-based 2D-3D registration algorithm formulated as a mixed-integer program to simultaneously solve for the correct transformation and data association. Our formulation is explicitly formulated to handle outliers, by modeling associations as integer variables. Additionally, we can constrain the registration to SE(2) to improve runtime and accuracy. We evaluate this search over multiple real-world data sets demonstrating adaptability to scene variation.
Age-independent seizure detection (2009)

This paper examines whether an appropriate algorithm, developed for use with neonatal data, could also be used, without alteration, for the detection of seizures in adults with epilepsy. The performance of a feature extraction and SVM classifier system is evaluated on databases of 17 neonatal patients and 15 adult patients. Mean ROC curve areas of 0.96 and 0.94 for neonatal and adult databases respectively show that high accuracy can be achieved independent of age. It is also shown that features contribute differently for neonatal and adult data.
High level transcription of the glucocerebrosidase pseudogene in normal subjects and patients with Gaucher disease. (1990)

Gaucher disease is due to mutations involving the glucocerebrosidase gene. A closely homologous pseudogene is located approximately 16 kD downstream from the functional gene. Sequence analysis of clones from cDNA libraries made from skin fibroblast cultures showed several independent clones with the sequence of an aberrantly processed pseudogene message. Examination of cellular RNA from lymphoblasts or fibroblasts obtained from thirteen Gaucher disease patients, one Gaucher disease heterozygote, and four normal subjects showed that the pseudogene was consistently transcribed, and that in some cases the level of transcription seemed to be approximately equal to that of the functional gene. The transcription of the pseudogene must be taken into account when attempting to detect mutations of glucocerebrosidase by the study of cDNA libraries.
A 1.3 GHz 100 kW Ultra-High Efficiency Klystron (2020)

Calabazas Creek Research, Inc. is developing a high efficiency, 1.3 GHz, 100 kW CW klystron for driving accelerators. A design with an efficiency of 79% has been generated, and fabrication is in progress.
Iterative Blind Data Detection In Constant Modulus Ofdm Systems (2008)

Publication in the conference proceedings of EUSIPCO, Lausanne, Switzerland, 2008
Seismic event classification using Self-Organizing Neural Networks (1991)

In the computer interpretation of seismic data, the critical first step is to identify the general class of an unknown event. For example, the classification might be: teleseismic, regional, local, vehicular, or noise. We have studied Self Organizing Neural Networks (SONNs) for classifying such events. Both Kohonen and Adaptive Resonance Theory (ART) SONNs were developed and tested with a moderately large set of real seismic events. Given the detection of a seismic event and the corresponding signal, we compute the time-frequency distribution, its binary representation, and finally a shift-invariant representation, which is the magnitude of the two-dimensional Fourier transform (2-D FFT) of the binary time-frequency distribution. This preprocessed input is fed into the SONNs. The overall results based on 111 events (43 training and 68 test events) show that SONNs are able to group events that ``look`` similar. We also find that the ART algorithm has an advantage in that the types of cluster groups do not need to be predefined. When a new type of event is detected, the ART network is able to handle the event rather gracefully. The results from the SONNs together with an expert seismologist`s classification are then used to derive event classification probabilities. Amore » strategy to integrate a SONN into the interpretation of seismic events is also proposed.« less
Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ<sub>1</sub> Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1<i>H</i>-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862) (2012)

The synthesis and pharmacological activity of a new series of 1-arylpyrazoles as potent σ(1) receptor (σ(1)R) antagonists are reported. The new compounds were evaluated in vitro in human σ(1)R and guinea pig σ(2) receptor (σ(2)R) binding assays. The nature of the pyrazole substituents was crucial for activity, and a basic amine was shown to be necessary, in accordance with known receptor pharmacophores. A wide variety of amines and spacer lengths between the amino and pyrazole groups were tolerated, but only the ethylenoxy spacer and small cyclic amines provided compounds with sufficient selectivity for σ(1)R vs σ(2)R. The most selective compounds were further profiled, and compound 28, 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862), which showed high activity in the mouse capsaicin model of neurogenic pain, emerged as the most interesting candidate. In addition, compound 28 exerted dose-dependent antinociceptive effects in several neuropathic pain models. This, together with its good physicochemical, safety, and ADME properties, led compound 28 to be selected as clinical candidate.
Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives (2001)

Oral contraceptives have been shown to be protective against hereditary ovarian cancer. The variant progesterone receptor allele named PROGINS is characterized by an Alu insertion into intron G and two additional mutations in exons 4 and 5. The PROGINS allele codes for a progesterone receptor with increased stability and increased hormone-induced transcriptional activity. We studied the role of the PROGINS allele as a modifying gene in hereditary breast and ovarian cancer. The study included 195 BRCA1 and BRCA2 carriers with a prior diagnosis of ovarian cancer, 392 carriers with a diagnosis of breast cancer and 249 carriers with neither cancer. Fifty-eight women had both forms of cancer. Five hundred and ninety-five women had a BRCA1 mutation and 183 women had a BRCA2 mutation. Overall, there was no association between disease status and the presence of the PROGINS allele. Information on oral contraception use was available for 663 of the 778 carriers of BRCA1 or BRCA2 mutations. Among the 449 subjects with a history of oral contraceptive use (74 cases and 365 controls), no modifying effect of PROGINS was observed [odds ratio (OR) 0.8; 95% confidence interval (CI) 0.5-1.3]. Among the 214 carriers with no past exposure to oral contraceptives, the presence of one or more PROGINS alleles was associated with an OR of 2.4 for ovarian cancer, compared to women without ovarian cancer and with no PROGINS allele (P = 0.004; 95% CI 1.4-4.3). The association was present after adjustment for ethnic group and for year of birth.
A general algorithm for oblique image reconstruction (1990)

It is shown how to generate oblique slices from a set of parallel slices. An algorithm that can produce planes or contours through the volume without any loss of the volume resolution of the original data set is presented. The algorithm uses the Fourier-shift theorem and is efficient for calculating large numbers of slices. Although the algorithm is general, it is particularly well suited for three-dimensional magnetic resonance images, as demonstrated with examples.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Halocyntin and papillosin, two new antimicrobial peptides isolated from hemocytes of the solitary tunicate, <i>Halocynthia papillosa</i> (2009)

We report here the screening of five marine invertebrate species from two taxa (tunicates and echinoderms) for the presence of cationic antimicrobial peptides (AMP) in defence cells (hemocytes). Antimicrobial activities were detected only in the two tunicates Microcosmus sabatieri and Halocynthia papillosa. In addition, we report the isolation and characterization of two novel peptides from H. papillosa hemocytes. These molecules display antibacterial activity against Gram-positive and Gram-negative bacteria. Complete peptide characterization was obtained by a combination of Edman degradation and mass spectrometry. The mature molecules, named halocyntin and papillosin, comprise 26 and 34 amino acid residues, respectively. Their primary structure display no significant similarities with previously described AMP.
Conservation of Antigenic Properties and Sequences Encoding the Envelope Proteins of Prototype Hantaan Virus and Two Virus Isolates from Korean Haemorrhagic Fever Patients (1988)

Viruses isolated from the blood of two Korean haemorrhagic fever patients were propagated in cell culture and compared to prototype Hantaan virus which was isolated from Apodemus mice. The antigenic properties of the human isolates were found to be closely related to Hantaan virus by plaque reduction neutralization, haemagglutination inhibition and fluorescent antibody staining with both polyclonal and monoclonal antibodies. The medium genome segment of each human isolate was sequenced and compared to that of Hantaan virus. Nucleotides comprising the Hantaan virus G1 and G2 envelope protein-coding regions differed from those of the other viruses by only 5.4% and 5.7%. The human isolates differed from one another by 1.6%. The nucleotide differences resulted in predicted amino acid variations of 1.3% to 2.3% among the three viruses, with the majority occurring as conservative substitutions in G1.