gebhart/patrepeval huggingface dataset:
Low-Pressure Solubility of Carbon Dioxide in Room-Temperature Ionic Liquids Measured with a Quartz Crystal Microbalance (2003)

The solubility of carbon dioxide in a series of imidazolium-based room-temperature ionic liquids has been determined using a quartz crystal microbalance. Henry's constants were obtained for CO2 in nine different ionic liquids: 1-methyl-3-propylimidazolium bis[trifluoromethylsulfonyl]amide (C3mimTf2N), 1-n-butyl-3-methylimidazolium bis[trifluoromethylsulfonyl]amide (C4mimTf2N), C4mimTf2N with polyethylenimine, 1-n-hexyl-3-methylimidazolium bis[trifluoromethylsulfonyl]amide (C6mimTf2N), 1-methyl-3-n-octylimidazolium bis[trifluoromethylsulfonyl]amide (C8mimTf2N), 1-methyl-3-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)imidazolium bis[trifluoromethylsulfonyl]amide (C8F13mimTf2N), 1,4-dibutyl-3-phenylimidazolium bis[trifluoromethylsulfonyl]amide, 1-butyl-3-phenylimidazolium bis[trifluoromethylsulfonyl]amide, and 1-methyl-3-propylimidazolium hexafluorophosphate (C3mimPF6). All results were obtained at 25 °C with CO2 pressures at or less than 1 bar. A comparison of results helps in understanding the role of chemical structure on the separation capabilities of these materials. Notable among the results is a significantly greater measured CO2 solubility in the ionic liquid having the fluorine-substituted cation as compared to the corresponding ionic liquid with a nonfluorinated cation. CO2 solubility was found to be lower in the ionic liquid containing PF6- than for the corresponding liquid with Tf2N- anion. Addition of an imine polymer to the ionic liquid did not significantly change CO2 solubility characteristics. The presence of water had a minor effect on CO2 solubility for C8mimTf2N for environments with a relative humidity of 40% or less. Henry's constant for CO2 in C3mimPF6 obtained in this study is in good agreement with previously reported Henry's constant values for CO2 in C4mimPF6 that were obtained by other means. This study not only provides some important thermodynamic property information for these unique materials but also illustrates the utility of using a quartz crystal microbalance to obtain this information.
Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system (1997)

Syrian hamster prion protein (PrPC) and a truncated Syrian hamster prion protein lacking the glycosylphosphatidylinositol (GPI) anchor C-terminal signal sequence (GPI-) were expressed in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system. The CHO cell clones expressing the GPI- PrP secreted the majority of the protein into the media, whereas most of the PrP produced by clones expressing the full-length protein with the GPI anchor was located on the cell surface, as demonstrated by its release upon treatment with phosphatidylinositol-specific phospholipase C (PIPLC). A cell clone that expressed the highest levels of full length PrP was subcloned to obtain clone 30C3-1. PrP from clone 30C3-1 was shown to be sensitive to proteolysis by proteinase K and to react with monoclonal and polyclonal antibodies that recognize native PrPC. The recombinant PrP migrated as a diffuse band of 19-40 kDa but removal of the N-linked oligosaccharides with peptide N-glycosidase F (PNGase F) revealed three protein species of 19, 17 and 15 kDa. The 19 kDa band corresponding to deglycosylated full-length PrP was quantified and found to be expressed at a level approximately 14-fold higher than that of PrPC found in Syrian hamster brain.
Oriented crystallization of poly(ethylene terephthalate) under uniaxial stretching (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOriented crystallization of poly(ethylene terephthalate) under uniaxial stretchingTakako Terada, Chie Sawatari, Toyoko Chigono, and Masaru MatsuoCite this: Macromolecules 1982, 15, 4, 998–1004Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://doi.org/10.1021/ma00232a010RIGHTS & PERMISSIONSArticle Views166Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
A framework for standards (1988)

The Orthopaedic Nursing Forum is I one of ten forums within the I Association of Nursing Practice f and its fastest achiever. Formed in 1986 it has already attracted a high level of sponsorship. Is well on the way to producing standards for orthopaedic nurses and is preparing for an International Conference for later this year.
Hereditary spastic paraparesis and psychosis (2006)

Hereditary spastic paraparesis (HSP) is characterized by progressive spasticity and weakness of the legs with or without additional abnormalities. Reports of psychiatric disorders in patients with HSP are limited to mood disturbances rather than to psychosis. We had noted significant psychotic illness in several patients recruited to a survey of HSP in Ireland and therefore set about examining the frequency and nature of psychosis in our patients with HSP. Cases with HSP and psychotic illness were identified from a nationwide epidemiological and clinical study. Psychiatric case notes were reviewed and Operational Diagnostic Criteria Checklist (OPCRIT) applied. Six patients from four families with HSP had evidence of psychosis in addition to paraparesis. OPCRIT diagnoses were 'narrow schizophrenia' (n = 2), 'broad schizophrenia' (n = 2) and 'schizo-affective/manic disorder' (n = 2). Patients were from families with Kjellin's syndrome and SPG4-HSP but not other kindreds and psychosis was not evident in family members without HSP. We found a higher than expected rate of psychosis in the Irish HSP population. Two groups of HSP patients may have increased risk of developing psychosis: those with Kjellin's syndrome and those with SPG4-HSP.
Non-Hodgkinʼs lymphoma (1996)

Attention is being directed at increasing the intensity of therapy as a means of improving the results of primary therapy for non-Hodgkin's lymphoma. There is increasing evidence that the use of high-dose consolidation therapy followed by autologous hematopoietic rescue in first remission improves survival in high-risk patients. There is also evidence from randomized trials that transplantation for relapsed patients improves survival compared with conventional salvage chemotherapy. Phase II trials of radiolabeled antibody therapy are providing promising results. There is still no definitive evidence that any treatment of advanced low-grade lymphoma prolongs survival, although the use of allogeneic bone marrow transplantation is under investigation. Treatment designed to eradicate Helicobacter pylori can cause regression in approximately 50% of patients with gastric lymphomas of mucosa-associated lymphoid tissue, although long-term follow-up information is lacking. The results of treatment for mantle cell lymphoma are poor and there is no consensus on management. Most trials of primary central nervous system lymphoma are employing systemic chemotherapy with drugs that penetrate the blood-brain barrier in addition to radiation.
Achieving high capacity with small cells in LTE-A (2012)

Due to the explosive growth of mobile data traffic, operators are increasingly facing the pressure of providing high data capacity to consumers while maintaining an efficient and low-cost network. In 3GPP LTE-A evolution, it has become clear that cell deployment is migrating towards a hybrid of macro-cell and small cells, where the macro-cell provides coverage and the small cells provide high capacity for hotspot and indoor users. This paper discusses the issues and solutions related to enhancing performance for such hybrid deployment in LTE-A, including interference management, mobility, carrier aggregation, and energy efficiency.
Fabrication and Characterisation of Polyaniline/Laponite based Semiconducting Organic/Inorganic Hybrid Material (2014)

Novel organic-inorganic semiconducting hybrid material is developed by chemically grafting polyaniline (PANI) onto an inorganic template, Laponite. The surface active silanol groups of the Laponite sheets were silylated with an aniline functionalised 3-phenylaminopropyltrimethoxysilane (PAPTMOS) coupling agent followed by deposition of PANI onto the silylated surface. The method includes the reaction of Laponite with PAPTMOS dissolved in a very small amount of methanol at 110 °C for 44 h in a vacuum oven, interaction of the silylated product with PANI via in situ polymerisation of aniline and one-step isolation process by means of the removal of the non-connected PANI with N-methylpyrrolidinone-diethylamine binary solvent. After isolation and re-doping with methane sulfonic acid the Laponite-PAPTMOS-PANI hybrid becomes electrically conductive. The chemical attachment of PANI with silylated Laponite in the hybrids were characterised by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, elemental analysis, and scanning electron microscopy. Defence Science Journal, Vol. 64, No. 3, May 2014, pp. 193-197, DOI:http://dx.doi.org/10.14429/dsj.64.7185
Theranostic Pt(IV) Conjugate with Target Selectivity for Androgen Receptor (2018)

It is difficult to diagnose and treat castration-resistant prostate cancer (CRPC) which occurs due to the overexpression of androgen receptor (AR). Because there is a high level of AR in CRPC, we designed and prepared three Pt(IV)-based prodrugs targeting AR. Among them, compound 3, a three-in-one hybrid (an AR binding ligand, a cisplatin unit, and a coumarin moiety), was found to display satisfactory AR binding affinity and antagonist activity against androgen receptor, which could also be effectively internalized and visualized in LNCaP (AR+) cells. Due to its AR affinity, 3 selectively accumulated in greater quantities in LNCaP (AR+) cells than in PC-3 (AR-) cells. Moreover, compound 3 exhibited excellent anticancer activity superior to cisplatin.These results highlight the targeting theranostic application of Pt(IV) prodrugs.
Classification of drivers manoeuvre for road intersection crossing with synthethic and real data (2017)

When approaching a road intersection, drivers consider several factors and choose amongst different likely manoeuvres. For an autonomous agent, it is fundamental to understand what other drivers are doing before deciding their own manoeuvres. These are seldom be the same as intersections differ and the situations too. Whilst, learning techniques can be used to process features of trajectories and to predict manoeuvres of others cars. The problem with such approaches is the difficult process of recording data for each intersection, not only of the subject vehicle but of the other vehicles. To address this problem, a hybrid data set was constructed. It is built in a simulated environment and completed with real data after has driven multiple times across the intersection. To analyze these data, classification technique is used to find the common range of features for each manoeuvre. Random forest classifiers are used in conjunction with our functional discretization to analyze the trajectories of cars approaching an intersection. The classifiers can determine the longitudinal manoeuvre as well as the direction. We show how our approach performs compared to other classifiers and space discretization. In addition, we demonstrate the impact and the usefulness of the mixture between simulated and real data. An improvement of 30% accuracy is obtained with the hybrid data set, and 5% using our functional discretization with respect to baseline approach.
Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. (2002)

The aromatic fatty acid sodium phenylbutyrate (PB) promotes cytostasis and differentiation in a wide variety of tumor types; among several molecular activities, inhibition of histone deacetylase (HDAC) may account for many of its pharmacodynamic effects. A Phase I study demonstrated promising preliminary evidence of clinical activity in acute myeloid leukemia and myelodysplastic syndrome; however, plasma concentrations achieved at the maximum tolerated dose were less than those targeted based on in vitro studies. Because prolonged exposure to suboptimal concentrations of PB in vitro led to pharmacodynamic changes similar to a more brief exposure to higher concentrations, a study of the feasibility of prolonged administration of sodium PB was performed. Selected patients with acute myeloid leukemia and myelodysplastic syndrome were treated with sodium PB as a continuous i.v. infusion via ambulatory infusion pump. Sequential cohorts were treated for 7 consecutive days out of 14 or with 21 consecutive days out of 28. Prolonged infusions were well tolerated; dose-limiting central nervous system toxicity developed in 1 of 23 patients treated. End-of-infusion plasma concentrations were maintained within a range sufficient to inhibit HDAC. Two patients on the 21/28 schedule developed hematological improvement. Prolonged infusions of PB are well tolerated making this an attractive platform for the clinical investigation of HDAC inhibition.
Supervised Wrapper Generation with Lixto (2001)

We illustrate basic features of the Lixto wrapper generator such as the user and system interaction, the capacious visual interface, the marking and selecting procedures, and the extraction tasks by describing the construction of a simple example program in the current Lixto prototype. 1.
Joint Transplantation (1985)

Eric Lexer1,2 was born in Freiburg, West Germany, and was the son of a professor ot German. During his adolescence, the family moved to Wurzburg, where Lexer attended the university, graduating from the medical school in 1890. Following a short period of postgraduate study of anatomy in Göttingen. Lexer began his surgical training in 1892 in the famous clinic of Ernst von Bergmann in Berlin. He remained there for 12 years. During this period he established himself as an investigator and a surgeon. Lexer was appointed Professor of Surgery in Konigsberg in 1905. He moved to Jena in 1910, Freiburg in 1919, and finally to Munich in 1928, where he was the successor to Sauerbruch. His reputation as a general and plastic surgeon continued to grow, with the years in Munich marking the zenith of his career. His clinic was crowded with patients, students, and visiting surgeons from throughout the world. Unfortunately, an acute coronary occlusion brought an abrupt end to his life in 1937, just prior to retirement. Lexer's early anatomic studies of the arterial circulation in the bones, coupled with his clinical work with patients with acute hematogenous osteomyelitis, formed the basis of our present understanding of the etiology and pathogenesis of these bony infections. His pioneer work on the transplantation of tissues such as fat, fascia, tendons, nerves, and bone continues to influence orthopedic and plastic surgery procedures today. His use of whole joints from cadavers as transplants into patients was just a small part of this work. We are fortunate that one of his students has compiled a bibliography of these papers.3 Lexer's life, which he lived to the fullest, was characterized by vitality and energy. His ego at times caused him to be abrasive and aggressive, but none of his contemporaries doubted his ability. His great artistic talent was sublimated in his surgical technique, which was of such a high level of virtuosity that it lent itself easily to showmanship. Lexer was a surgeon in a very broad sense who made substantial and lasting contributions to the development of the special areas of plastic and orthopedic surgery. Preservation of articular cartilage chondrocytes is currently being investigated in conjunction with storage and transplantation of osteochondral allografts. Studies on isolated chondrocytes have suggested that viability and function may be retained following freeze-preservation. Up to 90% of frozen isolated cells will survive, and these cells are capable of producing proteoglycans in culture. Results of freezing chondrocytes in a matrix have not been as successful, with viability ranging from 0% to 50%. Inconsistent results are thought to be due to the matrix and associated problems such as poor penetration of the cryopreservative, an unequal rate of cooling, and a high water content. Studies are in progress in an attempt to produce a satisfactory method of freeze-preservation that will promote normal functioning of chondrocytes after transplantation in an articular cartilage matrix.
Hemangiopericytoma of the lacrimal sac (1991)

Hemangiopericytomas are soft tissue tumors composed of pericapillary pericytes. These tumors are rare in the lacrimal sac. To the author's knowledge, only four previous cases of these tumors occurring in the lacrimal sac have been reported. A primary hemangiopericytoma of the lacrimal sac in a 34-year-old female is reported. Total excision with the surrounding tissue appears to be the treatment of choice for this tumor.
Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal System (2000)

Previous studies have used recombinant adeno-associated viral (rAAV) vectors to deliver glial cell line-derived neurotrophic factor (GDNF) in the substantia nigra to protect the nigral dopamine (DA) neurons from 6-hydroxydopamine-induced damage. However, no regeneration or functional recovery was observed in these experiments. Here, we have used an rAAV-GDNF vector to express GDNF long-term (6 months) in either the nigral DA neurons themselves, in the striatal target cells, or in both of these structures. The results demonstrate that both nigral and striatal transduction provide significant protection of nigral DA neurons against the toxin-induced degeneration. However, only the rats receiving rAAV-GDNF in the striatum displayed behavioral recovery, accompanied by significant reinnervation of the lesioned striatum, which developed gradually over the first 4-5 months after the lesion. GDNF transgene expression was maintained at high levels throughout this period. These results provide evidence that rAAV is a highly efficient vector system for long-term expression of therapeutic proteins in the nigrostriatal system.
Serum  -Tocopherol and Subsequent Risk of Lung Cancer Among Male Smokers (1999)

In the ATBC Study cohort, higher serum alpha-tocopherol status is associated with lower lung cancer risk; this relationship appears stronger among younger persons and among those with less cumulative smoke exposure. These findings suggest that high levels of alpha-tocopherol, if present during the early critical stages of tumorigenesis, may inhibit lung cancer development.
Speech and speech recognition during dictation corrections (2006)

A natural way to correct errors made while dictating to a computer is to respeak portions of the original sentence. But often spoken corrections are themselves misrecognized, costing the user time and testing their patience. To better understand how users behave while correcting, I created a simulated dictation interface and fooled users into believing they were correcting errors by respeaking. I found that users not only hyperarticulate during corrections, but they do so preemptively before any misrecognition. Depending on the recognizer, hyperarticulation was found to cause relatively minor changes in error rate. The correction of isolated words or phrases was more troublesome, causing substantial recognition problems for an HTK recognizer. Dragon Naturally Speaking, on the other hand, performed slightly better on hyperarticulated speech and only degraded slightly on isolated corrections.
Design and evaluation of an aerodynamic focusing micro-well aerosol collector (2017)

Aerosol sampling and identification is vital for the assessment and control of particulate matter pollution, airborne pathogens, allergens, and toxins and their effect on air quality, human health, and climate change. In-situ analysis of chemical and biological airborne components of aerosols on a conventional filter is challenging due to dilute samples in a large collection region. We present the design and evaluation of a micro-well (µ-well) aerosol collector for the assessment of airborne particulate matter (PM) in the 0.5-3 micron size range. The design minimizes particle collection areas allowing for in-situ optical analysis and provides an increased limit of detection for liquid-based assays due to the high concentrations of analytes in the elution/analysis volume. The design of the collector is guided by computational fluid dynamics (CFD) modeling; it combines an aerodynamic concentrator inlet that focuses the aspirated aerosol into a narrow beam and a µ-well collector that limits the particle collection area to the µ-well volume. The optimization of the collector geometry and the operational conditions result in high concentrations of collected PM in the submillimeter region inside the µ-well. Collection efficiency experiments are performed in the aerosol chamber using fluorescent polystyrene microspheres to determine the performance of the collector as a function of particle size and sampling flow rate. The collector has the maximum collection efficiency of about 75% for 1 micron particles for the flow rate of 1 slpm. Particles bigger than 1 micron have lower collection efficiencies because of particle bounce and particle loss in the aerodynamic focusing inlet. Collected samples can be eluted from the device using standard pipettes, with an elution volume of 10-20 microliters. The transparent collection substrate and the distinct collection region, independent of particle size, allows for in-situ optical analysis of the collected PM.
Peptide and protein carboxyl-terminal labeling through carboxypeptidase Y-catalyzed transpeptidation. (1990)

A survey of carboxypeptidase Y-catalyzed carboxyl-terminal modification of short peptides in the presence of various amino acids revealed that transpeptidation occurred in significant yield only with peptides containing a proline at the penultimate or antepenultimate position. For these peptides, transpeptidation was shown to occur specifically at the carboxyl side of the proline, thus suggesting a determining role of this residue for transpeptidation. Two model peptides, YPFP-GPI and YPFVEPI, were studied in detail. Initial yields of transpeptidation in the presence of various nucleophiles were compared. Among natural amino acids, the highest yield was obtained with methionine, followed by other amino acids bearing hydrophobic side chains. In order to transpose the method of transpeptidation to a protein, a variant of Escherichia coli methionyl-tRNA synthetase bearing the carboxyl-terminal Glu-Pro-Met sequence was genetically created. Under the conditions optimized for the transpeptidation of YPF-VEPI with methionine, this protein could be labeled specifically at its carboxyl-terminal end. Moreover, the parameters of the labeling reaction were in agreement with those observed in the transpeptidation of the model peptide.