gebhart/patrepeval huggingface dataset:
Vanadium corrosion studies. Final report, 1 February 1989-30 June 1993 (1993)

Vanadium present in certain crude and residual fuel oils, is converted within the burner of the gas turbine engine to the refractory dioxide, which in flight is fully oxidized to the pentoxide. Yttrium oxide, stable in the presence of the oxides of sulfur is identified and verified as a corrosion inhibitor. A chelation process to produce a hydrolytic stable fuel soluble yttrium additive is described.... Vanadium oxide corrosion, Hot corrosion, Sulfidation corrosion, Hot corrosion attenuation, Fuel additives, Water stable fuel soluble yttrium compounds, Chelation.
Discovery, Function, and Therapeutic Targeting of Siglec-8 (2020)

Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. Since its discovery in 2000, initial in vitro studies have found that the engagement of Siglec-8 with a monoclonal antibody or with selective polyvalent sialoglycan ligands induced the cell death of eosinophils and inhibited mast cell degranulation. Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects. AK002 (lirentelimab) is a humanized non-fucosylated IgG1 antibody against Siglec-8 in clinical development for mast cell- and eosinophil-mediated diseases. AK002 administration has safely demonstrated the inhibition of mast cell activity and the depletion of eosinophils in several phase 1 and phase 2 trials. This article reviews the discovery and functions of Siglec-8, and strategies for its therapeutic targeting for the treatment of eosinophil- and mast cell-associated diseases.
IMPROVED DISPERSANT BASED ON MICROEMULSION TECHNOLOGY (1989)

ABSTRACT An initial basic study focused on the interaction between dispersant surfactants and the oil-water interface. In essence, the study identified criteria to explain why a good dispersant is effective and why a poor dispersant is ineffective. The dynamic behavior of the oil-water interface, after the addition of the dispersant, was continuously monitored by a modified Wilhelmy plate device. This procedure provided much insight on the impact of the dispersant at the oil-water interface. One key finding of this study concerned the conditions for achieving very low interfacial tensions. It is known in microemulsion technology that a microemulsion formed by specific surfactants exhibits ultra-low interfacial tension against either oil or water. Microemulsion phase behavior studies then established that some specific surfactants, which form a certain type of microemulsion, are also highly effective dispersants, more effective than current state-of-the-art products. This improvement results in the formation of much finer dispersed oil droplets generated by a very minimum and lower level of energy. This paper will review the results of the basic study and the subsequent formulation of an improved dispersant. Laboratory and field data evaluating and supporting the improved overall performance will be presented.
A High‐Energy NASICON‐Type Cathode Material for Na‐Ion Batteries (2020)

Abstract Over the last decade, Na‐ion batteries have been extensively studied as low‐cost alternatives to Li‐ion batteries for large‐scale grid storage applications; however, the development of high‐energy positive electrodes remains a major challenge. Materials with a polyanionic framework, such as Na superionic conductor (NASICON)‐structured cathodes with formula Na x M 2 (PO 4 ) 3 , have attracted considerable attention because of their stable 3D crystal structure and high operating potential. Herein, a novel NASICON‐type compound, Na 4 MnCr(PO 4 ) 3 , is reported as a promising cathode material for Na‐ion batteries that deliver a high specific capacity of 130 mAh g −1 during discharge utilizing high‐voltage Mn 2+/3+ (3.5 V), Mn 3+/4+ (4.0 V), and Cr 3+/4+ (4.35 V) transition metal redox. In addition, Na 4 MnCr(PO 4 ) 3 exhibits a high rate capability (97 mAh g −1 at 5 C ) and excellent all‐temperature performance. In situ X‐ray diffraction and synchrotron X‐ray diffraction analyses reveal reversible structural evolution for both charge and discharge.
Personal dietary assessment using mobile devices (2009)

Dietary intake provides valuable insights for mounting intervention programs for prevention of disease. With growing concern for adolescent obesity, the need to accurately measure diet becomes imperative. Assessment among adolescents is problematic as this group has irregular eating patterns and have less enthusiasm for recording food intake. Preliminary studies among adolescents suggest that innovative use of technology may improve the accuracy of diet information from young people. In this paper we describe further development of a novel dietary assessment system using mobile devices. This system will generate an accurate account of daily food and nutrient intake among adolescents. The mobile computing device provides a unique vehicle for collecting dietary information that reduces burden on records that are obtained using more classical approaches. Images before and after foods are eaten can be used to estimate the amount of food consumed.
Müllerian inhibiting substance/anti-Müllerian hormone as a fertility preservation agent (2018)

The usefulness of MIS as a fertoprotectant may be dependent on the mechanisms of gonadotoxicity of each chemotherapeutic. Further investigation is needed to determine how to best deliver and combine MIS treatment to existing fertility management strategies.
Characterization of an Omega-3 Desaturase From Phytophthora parasitica and Application for Eicosapentaenoic Acid Production in Mortierella alpina (2018)

Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) have important therapeutic and nutritional benefits in humans. In the biosynthesis pathways of these LC-PUFAs, omega-3 desaturase plays a critical role. In this study, we report a new omega-3 desaturase (PPD17) from <i>Phytophthora parasitica</i>. This desaturase shares high similarities with the known omega-3 desaturases and was expressed in <i>Saccharomyces cerevisiae</i> for the activity and substrate specificity research. The desaturase has a wide omega-6 fatty acid substrate, containing both 18C and 20C fatty acids, and exhibits a strong activity of delta-17 desaturase but a weak activity of delta-15 desaturase. The new desaturase converted the omega-6 arachidonic acid (AA, C20:4) to EPA (an omega-3 LC-PUFA, C20:5) with a substrate conversion rate of 70%. To obtain a high EPA-producing strain, we transformed PPD17 into <i>Mortierella alpina</i>, an AA-producing filamentous fungus. The EPA content of the total fatty acids in reconstruction strains reached 31.5% and was followed by the fermentation optimization of the EPA yield of up to 1.9 g/L. This research characterized a new omega-3 desaturase and provides a possibility of industrially producing EPA using <i>M. alpina</i>.
Face Model Fitting on Low Resolution Images (2006)

Active Appearance Models (AAMs) represent the shape and appearance of an object via two low-dimensional subspaces, one for shape and one for appearance. AAMs for facial images are currently receiving considerable attention from the vision community. However, most existing work focuses on fitting AAMs to high-quality facial images. For many applications, effectively fitting an AAM to low-resolution facial images is of critical importance. This paper addresses this challenge from two aspects. On the modeling side, we propose an iterative AAM enhancement scheme, which not only results in increased fitting speed, but also improves the fitting robustness. For fitting AAMs to low-resolution images, we build a multi-resolution AAM and show that the best fitting performance is obtained when the model resolution is slightly higher than the facial image resolution. Experimental results using both indoor video and outdoor surveillance video are presented.
High-sensitivity low-coherence dynamic light scattering and particle sizing for nanoparticles (2011)

We have developed a high-sensitivity, low-coherence dynamic light scattering system for the measurement of particles a few tens of nanometers in size. A Mach-Zehnder interferometer and a confocal optical system were adopted for improved sensitivity to scattered light intensity. The developed system can detect scattered light 3000 times weaker than that detectable by a previous system. We applied the newly developed system to measure the particle size distribution of 10 vol.% polystyrene particles with an average diameter of 13 nm. The obtained particle size distribution agreed quite well with a distribution determined by transmission electron microscopy.
ALDAI (2006)

In the framework of the LegDoC project at XRCE, we present a document annotation interface with an integrated active learning component. The interface is designed for automating the annotation of layout-oriented documents with semantic labels. We describe core functionalities of the interface; we pay a particular attention to the learning component, including the feature management and different strategies of deploying the active learner in the document annotation.
N-(3-Azidophenyl)-N-methyl-N'-([4-1H]- and [4-3H]-1-naphthyl)guanidine. A potent and selective ligand designed as a photoaffinity label for the phencyclidine site of the N-methyl-D-aspartate receptor (1993)

A novel radiolabeled photoaffinity ligand has been synthesized for the phencyclidine (PCP) site of the N-methyl-D-aspartate (NMDA) receptor. N-(3-Azidophenyl)-N-methyl-N'-([4-3H]-1-naphthyl)guanidine (13) was prepared with a specific activity of 25 Ci/mmol by diazotization of N-(3-aminophenyl)-N-methyl-N'-([4-3H]-1-naphthyl)guanidine (12) followed by treatment with sodium azide. Guanidine 12 was obtained by catalytic tritiation of N-(4-bromo-1-naphthyl)-N'-methyl-N'-(3-nitrophenyl)guanidine (11). The nontritiated analog 5 of 13 was prepared beginning with N-methyl-N'-1-naphthyl-N-(3-nitrophenyl)guanidine (9). The guanidines 9 and 11 were prepared in moderate yield by the aluminum chloride-catalyzed reaction of N-methyl-3-nitroaniline hydrochloride with 1-naphthylcyanamide and 4-bromo-1-naphthylcyanamide, respectively. Azide 5 showed high selectivity and affinity (IC50 = 100 nM vs [3H]MK801; 3000 nM vs [3H]ditolylguanidine) for the PCP site of the NMDA receptor in guinea pig brain homogenate. Photolabeling experiments with 13, however, failed to radiolabel a significant amount of receptor polypeptide.
Analysis of a statistics counter architecture (2002)

Packet switches (e.g., IP routers, ATM switches and Ethernet switches) maintain statistics for a variety of reasons: performance monitoring, network management, security, network tracing, and traffic engineering. The statistics are usually collected by counters which might, for example, count the number of arrivals of a specific type of packet, or count particular events, such as when a packet is dropped. The arrival of a packet may lead to several different statistics counters being updated. The number of statistics counters and the rate at which they are updated is often limited by memory technology. A small number of counters may be held in on-chip registers or in (on- or off-chip) SRAM. But often, the number of counters is very large, and hence they need to be stored in off-chip DRAM. However, the large random access times of DRAMs make it difficult to support high bandwidth links. The time taken to read, update and write a single counter would be too large, and worse still multiple counters may need to be updated for each arriving packet. In this paper we consider a specific architecture for storing and updating statistics counters. Smaller sized counters are maintained in fast (potentially on-chip) SRAM, while a large, slower DRAM maintains the full-sized counters. The problem is to ensure that the counter values are always correctly maintained at line-rate. We describe and analyze an optimal counter management algorithm (LCF-CMA), which minimizes the size of the SRAM required while ensuring correct line-rate operation of a large number of counters.
Removal of Copper Ions by Micelle-Based Separation Processes. Electrochemical Behavior of Copper Ions Trapped in Micellar Particles (1997)

Micellar-based separation processes have been shown in the past few years to be especially attractive for the removal of metal ions from dilute aqueous solutions, when micellar extraction is combined with ultrafiltration. In the present paper we consider two ways of removing copper ions from micellar processes: the first is based on ion-exchange (anionic SDS micelles), the second on metal ion complexation by a micelle-solubilized extractant (CTAB/butanol/water/Kelex 100 microemulsions). The influence of the relative concentrations of the species involved and of the pH on the yield of extraction is investigated, and in the first case the results are compared with a theoretical prediction. In a second part we compare for the first time the electrochemical behavior of copper ions whether they are simply bound to the micelle surface or more deeply imbedded in the core of a microemulsion as a hydrophobic complex. The electroreduction of the copper ions is easily obtained when the metal ions are simply bound to the micellar surface, offering a way of recycling the micellar phase after the metal ions have been removed. The situation is more complicated when the copper ions form stable complexes solubilized in microemulsions, since the electroreduction is possible only once the complex has been destroyed in acidic media.
Method of encoding speech signals involving the extraction of speech formant candidates in real time (1992)

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<title>Secure fiber optic communication system based on the Sagnac interferometer</title> (1996)

The Sagnac interferometer may be used to support high speed secure fiber optic data links over distances of more than 10 km. This paper provides a description of the basic system and describes how it may be applied to campus and local area network applications.
Fluorescent sophorolipid molecular assembly and its magnetic nanoparticle loading: a pulsed laser process (2013)

We report realization of strong green fluorescence in a fully biocompatible highly spherical mesoscale molecular assembly of sophorolipid created by pulsed UV laser processing of a water-based dispersion of sophorolipid. Remarkably, the said fluorescence is totally absent in the original molecule of sophorolipid and is thus the property of the pulsed laser induced modifications in the molecule and the assembly. We have separately examined the consequences of laser irradiation for glucose and oleic acid components which form the sophorolipid. This fluorescence character appears to be driven by the oleic acid component while the assembly process is assisted by the glucose component. Importantly the laser synthesized mesostructures can be easily redispersed in an aqueous medium after being dried and can also be loaded with magnetic nanoparticles (magnetite) for inducing the hyperthermia effect.
Abstract 20069: Serum-Free Culture Conditions Support Human Cardiac Stem Cell Outgrowth (2014)

Introduction: Autologous cardiac stem cell (CSC) therapies represent an emerging treatment option for patients with congestive heart failure. Unfortunately, straightforward translation to the clinic is limited by traditional culture conditions that are supplemented by ill-defined or xenobiotic components such as fetal bovine serum. As such, overcoming these barriers is the next critical step in developing next generation CSC therapies for clinical use. Methods/Results: Transition of CSC culture methods to serum-free, xeno-free culture conditions demonstrated negligible effects on the overall numbers of cells cultured with equivalent cardiac (c-Kit+; 7.8±0.2 %, p=0.34) and mesenchymal (CD90+; 32±7 %, p=0.57) progenitor content as compared to standard culture conditions. Flow cytometry morphometry demonstrated that serum free cells provide a smaller, more homogeneous cell product. Exposure to hypoxic stress conditions demonstrated equivalent secretion of SDF-1α, SCF, HGF, and VEGF-A with reduced production of the pro-inflammatory cytokine IL-6 from serum-free cells (7±2 fold less; p=0.005). Despite differences in cytokine production, conditioned media from serum-free CSCs promoted similar new vessel formation (37±5 vs. 41±7 % of positive control within a HUVEC tube formation assay; p=0.69) and circulating stem cell recruitment (39±9 vs. 47±12% of the positive control within a transwell assay, p=0.64) when compared to media conditioned by standard cultures. Storage of cell suspensions at 4°C had negligible effects on 12 hour viability (95.3±1.6%, p=0.50), suggesting a shelf life sufficient for transport between institutions. Finally, injection of CSCs through a clinically approved coronary artery perfusion catheter did not alter cell viability (99.2±1.7 % after delivery, p=0.77) while ensuring successful product delivery to the peri-infarct zone. Conclusions: Transitioning CSCs to clinically acceptable protocols provides a more uniform cell product ready for clinical delivery. These findings represent the first published evidence that altered serum-free xeno-free culture conditions can provide a superior CSC cell product with the potential for ready translation to clinical use.
Atlantic herring low-frequency target strength and abundance estimation: Ocean acoustic waveguide remote sensing (OAWRS) 2006 Experiment in the Gulf of Maine. (2008)

The mean low-frequency target strength (TS) of spawning Atlantic herring populations in the Gulf of Maine is estimated from the experimental data acquired during September–October 2006 near the northern flank of Georges Bank. A low-frequency OAWRS system with an instantaneous imaging diameter of 100 km was deployed to provide spatially unaliased imaging of fish populations over wide areas. The OAWRS system’s scattering strength measurements are calibrated with areal fish population density estimates obtained from concurrent localized line-transect measurements with several conventional fish finding sonars (CFFSs). Trawl sampling at selected locations enables the identification of the imaged species. The mean TS estimates of herring individuals exhibits significant variation over OAWRS operating frequency range, in accordance with the results from a resonant scattering model for swimbladder-bearing fish. The neutral buoyancy depth of herring and the species composition in the imaged population is inferred by comparing the measured TS with those derived from the model. Our analysis indicates that the herring population has a neutral buoyancy depth of between 70 and 90 m and is therefore negatively buoyant between 120 and 180 m water depth at which it is commonly found. The herring populations instantaneously imaged with OAWRS often exceeds 200×106, of which over 150×106 individuals can be organized into a large shoal.
A gamma camera for medical applications, using a multiwire proportional counter. (1984)

A multiwire proportional counter gamma camera, specifically designed for nuclear medicine applications, is portable and weighs less than 50 lb including shielding and collimator. The basic operating characteristics have been investigated with various radioactive sealed sources. The camera demonstrates a peak count rate of 850,000 cps, an intrinsic spatial resolution of 2.5 mm, and excellent image uniformity when used with x-ray sources in the range of 22-81 keV. Tests of the device with Ta-178--a very promising, short half-life (9.3 min), low-energy radionuclide--using 20 mCi injections provided images of quality comparable to those obtained from 15 mCi Tc-99m studies with conventional imaging devices. The camera used with Ta-178 offers particular promise in first-pass nuclear cardiology studies. Considerably improved study quality will likely result in this area because of the increased injectable dose levels offered by Ta-178 combined with the high-count rate capability and improved resolution.
Polymorphisms of the Regulators of Complement Activation Gene Cluster (1990)

The regulators of complement activation (RCA) constitute a tightly linked gene family that controls the activity of the complement system. Genetic polymorphisms have been reported for all of RCA genes at the DNA, RNA and/or protein levels. In addition, multiple RNA and/or protein products have been observed for most of these genes. These polymorphisms and variants are instrumental in the study of the structure, evolution and function of the RCA family.
A DLL-Supported, Low Phase Noise Fractional-N PLL With a Wideband VCO and a Highly Linear Frequency Ramp Generator for FMCW Radars (2013)

This paper describes a frequency synthesizer for frequency-modulated continuous wave (FMCW) radars, operating in combination with a frequency multiplier, at 77 GHz. The fractional-N phase-locked loop (PLL)-based synthesizer is equipped with a wideband voltage-controlled oscillator, which is realized with CMOS transistors in a current-reuse technique, and a delay-locked loop (DLL). Utilized as a frequency multiplier for the reference signal, the DLL improves both the phase noise performance of the PLL and the linearity of the frequency sweep generated by the PLL. Two types of voltage-controlled delay lines used in the DLL are also introduced and compared in this paper. Both show a good performance in terms of phase noise and can be easily realized in a standard CMOS technology. The false-lock issue of the DLL is also discussed and a solution is proposed. Furthermore, a frequency multiplier is used to multiply the output frequency of the PLL by a multiplication factor of 18. This architecture enables an increase in the target resolution and an improvement in the accuracy of the measurements of FMCW radars.
Planar Particle Imaging Doppler Velocimetry: A Three Component Velocity Measurement Technique (2005)

Digital particle imaging velocimetry (DPIV) is a high-resolution, high-accuracy, planar velocimetry technique, which provides valuable instantaneous velocity information in aeropropulsion test facilities. DPIV is capable of providing three-component flowfield measurements using a two-camera, stereo-viewing configuration. Doppler global velocimetry (DGV) is another planar velocimetry technique, which is also capable of providing three-component flow field measurements, but requires three detector systems that must be located at oblique angles from the measurement plane. The three-dimensional configurations of either technique require multiple (DGV) or at least large (stereo PIV) optical access ports in the facility in which the measurements are being conducted. In some test facilities, limited optical access is available (either a single viewing window or small optical access port), which prohibits the implementation of either technique for three-component flow measurements. A hybrid measurement technique is described, called planar particle image Doppler velocimetry (PPIDV), which combines elements from both the DPIV and DGV techniques into a single detection system capable of measuring all three components of velocity across a planar region of a flowfield through a single optical access port. The PPIDV system utilizes common components between the DPIV and DGV systems to reduce system complexity and costs. Measurements of a rotating wheel are used to verify the integrity of the technique. Then simultaneous measurements of a nozzle flow are obtained using both a stereo-viewing DPIV system and a PPIDV system.