gebhart/patrepeval huggingface dataset:
Cerebral Beta Amyloid Angiopathy Is a Risk Factor for Cerebral Ischemic Infarction. A Case Control Study in Human Brain Biopsies (2000)

Cerebral amyloid angiopathy (CAA) is conspicuous for its association with Alzheimer disease (AD) and as a cause of lobar hemorrhages in the elderly, but its role in cerebral infarction is less clear. There is evidence that CAA may also be a risk factor for ischemic infarction in AD. To further investigate CAA as a risk factor for infarction, we studied 108 cases of recent cerebral or cerebellar infarction diagnosed in tissue samples obtained from surgical material. There were 69 males and 39 females with a mean age of 52 yr (range 1-86). The majority of biopsies were obtained from the frontal and parietal lobes. Radiological studies demonstrated a lesion confined to a vascular distribution in 12 of the 17 (71%) cases examined. Microscopic sections stained with hematoxylin and eosin revealed complete, organizing infarction in 107 cases with areas of coagulative necrosis, anoxic-ischemic neuronal injury, inflammation, macrophages, vascular proliferation, gliosis, and swollen axons. One case showed an incomplete infarct. Most cases also exhibited a minor hemorrhagic component with hemosiderin and hematoidin pigments. CAA, defined as amyloid deposition in the walls of leptomeningeal and parenchymal arteries, was found by immunohistochemical stains for beta amyloid in 14 (13%) cases of complete cerebral infarct. Cortical beta amyloid plaques were found by immunohistochemistry in 19 (17%) cases. Cerebral or cerebellar tissues containing cortex and leptomeninges obtained from 136 patients with a mean age of 52 yr (range 1-85) during surgical procedures for diagnosis of primary or metastatic neoplasms and demyelinating lesions were used as age-matched controls. In this control group, CAA was found in 5 (3.7%) and beta amyloid plaques in 19 (14%). The results indicate that CAA, but not beta amyloid plaque formation, is significantly more common in patients with ischemic cerebral infarction than in age-matched controls with nonvascular lesions (odds ratio 3.8; 95% confidence interval 1.3-10.9; p < 0.01). Our results indicate that CAA is a risk factor for ischemic cerebral infarction in the population studied.
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors (2007)

Human colonic epithelial cell renewal, proliferation, and differentiation are stringently controlled by numerous regulatory pathways. To identify genetic programs of human colonic epithelial cell differentiation in vivo as well as candidate marker genes that define colonic epithelial stem/progenitor cells and the stem cell niche, we applied gene expression analysis of normal human colon tops and basal crypts by using expression microarrays with 30,000 genes. Nine hundred and sixty-nine cDNA clones were found to be differentially expressed between human colon crypts and tops. Pathway analysis revealed the differential expression of genes involved in cell cycle maintenance and apoptosis, as well as genes in bone morphogenetic protein (BMP), Notch, Wnt, EPH, and MYC signaling pathways. BMP antagonists gremlin 1, gremlin 2, and chordin-like 1 were found to be expressed by colon crypts. In situ hybridization and RT-PCR confirmed that these BMP antagonists are expressed by intestinal cryptal myofibroblasts and smooth muscle cells at the colon crypt. In vitro analysis demonstrated that gremlin 1 partially inhibits Caco-2 cell differentiation upon confluence and activates Wnt signaling in normal rat intestinal epithelial cells. Collectively, the expression data set provides a comprehensive picture of human colonic epithelial cell differentiation. Our study also suggests that BMP antagonists are candidate signaling components that make up the intestinal epithelial stem cell niche.
The Plank: Designing A Simple Haptic Controller. (2002)

Active force-feedback holds the potential for precise and rapid controls. A high performance device can be built from a surplus disk drive and controlled from an inexpensive microcontroller. Our new design,The Plank has only one axis of force-feedback with limited range of motion. It is being used to explore methods of feeling and directly manipulating sound waves and spectra suitable for live performance of computer music.
Binding Kinetics of ATP γ S35 on Cultured Primary Tracheal Surface Epithelial Cells (1994)

Extracellular ATP can stimulate mucin release from primary hamster tracheal surface epithelial (HTSE) cells via a P2 purinoceptor-mediated mechanism, based on agonist potency studies of mucin release (Br. J. Pharmacol. 1991; 103:1053-1056). In the present study, we examined the kinetics of ATP binding to the surface of intact HTSE cells at 4 degrees C using ATP gamma S35 as a radioligand. We found that ATP gamma S35 bound to HTSE cells in a saturable, reversible manner, reaching an equilibrium at about 30 min. Scatchard analysis of equilibrium binding suggested the presence of two binding sites with Kd values of 0.47 and 9.4 microM. Competitive binding experiments, based on the ability of nucleotides and ATP analogs to block ATP gamma S35 revealed a rank order of ATP > ADP > alpha,beta-methylene ATP > 2-methylthio ATP > or = beta, gamma-methylene ATP. Neither AMP nor adenosine could inhibit the ATP gamma S35 binding. A comparison between the ability of nucleotides to compete with ATP gamma S35 binding and their ability to induce mucin release revealed a rather poor correlation (r2 = 0.67) with all of the above nucleotides but a good correlation (r2 = 0.96) without 2-methylthio ATP, indicating the presence of heterogenous ATP binding sites on the HTSE cell surface. UTP, a pyrimidine nucleotide, which is almost equipotent with ATP in its ability to stimulate mucin release, was much less potent than ATP in its ability to displace the ATP gamma S35 binding in these HTSE cells.
[Impulse photoconductivity of solutions of chlorophyll and its analogs. II. Effect of medium polarity on the yield of ion-radicals during the photoxidation of chlorophyll a ]. (1975)

The effect of the dielectric constant epsilon of the solvent on the yield delta n of ion-radicals during photooxidation of chlorophy-l a with n-benzoquinone was studied by the method of impulse photoconductivity. It was shown that in the studied range of dielectric constant valve (epsilon congruent to 5-25) delta n monotonously increased with an increase of epsilon the relationship delta n (epsilon) being of clearly pronounced S-like character with a bend in the region of epsilon congruent to 10. A half-quantitative explanation of the data obtained is presented.
Hepatitis C Virus, Antibodies, and Infectivity: <i>Paradox, Pragmatism, and Policy</i> (1992)

Hepatitis C Virus, Antibodies, and Infectivity: Paradox, Pragmatism, and Policy Get access Roger Y. Dodd, Ph.D. Roger Y. Dodd, Ph.D. Head, Transmissible Diseases Laboratory American Red Cross Jerome H. Holland Laboratories Rockville, Maryland Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 97, Issue 1, 1 January 1992, Pages 4–6, https://doi.org/10.1093/ajcp/97.1.4 Published: 01 January 1992
Building an Intrusion Detection System Using a Filter-Based Feature Selection Algorithm (2016)

Redundant and irrelevant features in data have caused a long-term problem in network traffic classification. These features not only slow down the process of classification but also prevent a classifier from making accurate decisions, especially when coping with big data. In this paper, we propose a mutual information based algorithm that analytically selects the optimal feature for classification. This mutual information based feature selection algorithm can handle linearly and nonlinearly dependent data features. Its effectiveness is evaluated in the cases of network intrusion detection. An Intrusion Detection System (IDS), named Least Square Support Vector Machine based IDS (LSSVM-IDS), is built using the features selected by our proposed feature selection algorithm. The performance of LSSVM-IDS is evaluated using three intrusion detection evaluation datasets, namely KDD Cup 99, NSL-KDD and Kyoto 2006+ dataset. The evaluation results show that our feature selection algorithm contributes more critical features for LSSVM-IDS to achieve better accuracy and lower computational cost compared with the state-of-the-art methods.
Hybrid Computing Techniques for Collaborative Control of UCAVs (2005)

This paper presents a new approach to collaborative control of multiple Uninhabited Combat Aerial Vehicles (UCAVs) using hybrid soft and hard computing techniques. The approach develops a hierarchical architecture, which consists of four separate layers. The first layer describes the navigational system responsible for mission planning/re-planning, target priority, target distribution among individual UCAVs, and communication/collaboration between all UCAVs in the battlefield. The second layer describes the sensor fusion/definition on each individual UCAV. The third layer describes a fuzzy interpretation system (FIS) in which static and dynamic threat avoidance, and real-time path planning are outlined. The fourth and final layer contains the individual UCAV plant dynamics, autopilot, and navigation subsystem which accepts heading, altitude, and velocity commands. Extensive simulations are given to validate the proposed approach for any number of UCAVs flying in the battlefield.
A framework for automated software partitioning and mapping for distributed multiprocessors (2002)

One of the major impediments to the widespread use of large-scale, distributed memory multiprocessors is the difficulty of efficiently partitioning and mapping application algorithms onto these machines so as to extract a large portion of the machines' peak performance. In this paper, we present the preliminary accomplishments of an ongoing effort aimed at automating the complex tasks of software partitioning and mapping during the: system definition phase of application development for distributed memory multiprocessors. We describe a technique called the Augmented Task Dependency Graph (ATDG) for representing the high-level design of the application software. The ATDG allows one to express functional parallelism as well as data parallelism in a manner that facilitates automated partitioning and mapping. We propose a new strategy for searching through the possible space of design choices for partitioning and mapping. The proposed approach, called hierarchical hybrid search, organizes the search space as a hierarchy of sub-spaces. It permits the use of different search techniques for searching through different search sub-spaces. Examples of search techniques that could be employed in the proposed approach include hill-climbing, simulated annealing, and genetic algorithms.
Interobserver and intraobserver variation in the morphological evaluation of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features in Asian practice (2019)

To evaluate the current diagnostic criteria in reporting nuclear features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), nine Asian pathologists with expertise in thyroid reviewed virtual slides of 30 noninvasive follicular patterned thyroid lesions according to the nuclear scoring system originally proposed by an international expert and a more detailed scoring system proposed by the Asian Working Group. The interobserver agreement for nuclear grading score was generally moderate (kappa value = 0.452). The best consistency fell on the chromatin features (kappa value = 0.658-1.000). A fair to moderate interobserver agreement was demonstrated in the evaluation of nuclear elongation, nuclear overlapping, membrane irregularities and distribution of papillary thyroid carcinoma (PTC) type nuclear features. A slight agreement was rendered for the evaluation of the nuclear enlargement. Intraobserver agreement was substantial to perfect when comparing results of both scoring systems. However, both scoring systems were not able to reliably separate NIFTP from an encapsulated follicular variant PTC with minimal lymph node metastasis or BRAF<sup>V600E</sup> mutation. Although the three-point nuclear scoring system for the diagnosis of NIFTP is widely used in Asian practice, interobserver variation was considerable. Ancillary immunohistochemical or molecular testing might be helpful in differentiating NIFTP from true PTC.
Data access microarchitectures for superscalar processors with compiler-assisted data prefetching (1991)

Article Data access microarchitectures for superscalar processors with compiler-assisted data prefetching Share on Authors: William Y. Chen Center for Reliable and High-Performance Computing, University of Illinois, Urbana, Illinois Center for Reliable and High-Performance Computing, University of Illinois, Urbana, IllinoisView Profile , Scott A. Mahlke Center for Reliable and High-Performance Computing, University of Illinois, Urbana, Illinois Center for Reliable and High-Performance Computing, University of Illinois, Urbana, IllinoisView Profile , Pohua P. Chang Center for Reliable and High-Performance Computing, University of Illinois, Urbana, Illinois Center for Reliable and High-Performance Computing, University of Illinois, Urbana, IllinoisView Profile , Wen-mei W. Hwu Center for Reliable and High-Performance Computing, University of Illinois, Urbana, Illinois Center for Reliable and High-Performance Computing, University of Illinois, Urbana, IllinoisView Profile Authors Info & Claims MICRO 24: Proceedings of the 24th annual international symposium on MicroarchitectureSeptember 1991 Pages 69–73https://doi.org/10.1145/123465.123478Online:01 September 1991Publication History 88citation318DownloadsMetricsTotal Citations88Total Downloads318Last 12 Months8Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Research priorities for harnessing plant microbiomes in sustainable agriculture (2017)

Feeding a growing world population amidst climate change requires optimizing the reliability, resource use, and environmental impacts of food production. One way to assist in achieving these goals is to integrate beneficial plant microbiomes-i.e., those enhancing plant growth, nutrient use efficiency, abiotic stress tolerance, and disease resistance-into agricultural production. This integration will require a large-scale effort among academic researchers, industry researchers, and farmers to understand and manage plant-microbiome interactions in the context of modern agricultural systems. Here, we identify priorities for research in this area: (1) develop model host-microbiome systems for crop plants and non-crop plants with associated microbial culture collections and reference genomes, (2) define core microbiomes and metagenomes in these model systems, (3) elucidate the rules of synthetic, functionally programmable microbiome assembly, (4) determine functional mechanisms of plant-microbiome interactions, and (5) characterize and refine plant genotype-by-environment-by-microbiome-by-management interactions. Meeting these goals should accelerate our ability to design and implement effective agricultural microbiome manipulations and management strategies, which, in turn, will pay dividends for both the consumers and producers of the world food supply.
A GGCAGG motif in minisatellites affecting their germline instability. (1990)

Mouse and human genomes contain hypervariable DNA regions consisting of tandem repeats of a short sequence referred to as minisatellites. This variation is thought to arise through processes such as unequal crossover or replication slippage. A mo-1 minisatellite probe comprising a 14-base pair repeat sequence reveals many polymorphic fragments even in DNA of BALB/c sublines. Oligonucleotide probes with single base substitution in the mo-1 have been synthesized and used for assessing sequence involved in generation of polymorphisms. The results indicate that the loci containing mo-1 homologues with mutation in the GGCAGG sequence are monomorphic despite the other mutants showing polymorphism. Reciprocally, locus-specific polymorphic clones, Pc-1 and Pc-2, have been isolated with hybridization to mo-1, and both are shown to contain repeated sequence comprising the GGCAGG sequence. They reveal high mutation rates of 8.8% and 3.3% per gamete, respectively. These results strongly suggest that the motif contributes to the germline instability of minisatellites.
Design and construction of mobility assistive hybrid automobile for impaired persons (2016)

This paper presents the design and implementation of an hybrid automobile as a mobility assistive device for impaired people. The design of the vehicle is divided into three units namely mechanical, electrical and software design. The mechanical unit is concerned with the design of vehicle structure so that the vehicle can equally be used both for indoor as well as outdoor environments. The electrical part is related to the deployment of sensors and design of hardware circuits for powering the sensors and actuators. The software unit is responsible for providing the user with different navigation modes. The validity of the designed vehicle is proven through experimentation in different environments.
Development of Through Silicon Via (TSV) interposer for memory module flip chip package (2012)

With the trend of microelectronics packaging toward more functionality, high performance and smaller form factor, the product is required to deliver more I/Os and better electrical characteristics under a minimum module system. Therefore, a 3D IC integration System in Package (SiP) with passive Through Silicon Via (TSV) interposer technology is proposed to provide high density and heterogeneous integration needed for such requirement. Due to the Coefficients of Thermal Expansion (CTE) mismatch between materials, thermal-mechanical stress and warpage are induced during Through Silicon Interposer (TSI) fabrication process, which may affect TSV crack or Controlled Collapse Chip Connection (C4) bump crack after TSI bonding to organic substrate process. Therefore, this work is a step by step process simulation with various design parameters by finite element method (FEM) to investigate stress and warpage behaviors of processing effect. For both full array dummy bumps layout and thinner top chips are to reduce micro-bump stress. Also, low CTE organic substrate core, high CTE mold compound and thinner top chips perform lower package warpage. Finally, this paper aims to provide a guideline to designer for 3D IC integration SiP with passive TSV interposer structure by using the finite element models.
Smart guiding glasses for visually impaired people in indoor environment (2017)

To overcome the travelling difficulty for the visually impaired group, this paper presents a novel ETA (Electronic Travel Aids)-smart guiding device in the shape of a pair of eyeglasses for giving these people guidance efficiently and safely. Different from existing works, a novel multi-sensor fusion based obstacle avoiding algorithm is proposed, which utilizes both the depth sensor and ultrasonic sensor to solve the problems of detecting small obstacles, and transparent obstacles, e.g. the French door. For totally blind people, three kinds of auditory cues were developed to inform the direction where they can go ahead. Whereas for weak sighted people, visual enhancement which leverages the AR (Augment Reality) technique and integrates the traversable direction is adopted. The prototype consisting of a pair of display glasses and several low-cost sensors is developed, and its efficiency and accuracy were tested by a number of users. The experimental results show that the smart guiding glasses can effectively improve the user’s travelling experience in complicated indoor environment. Thus it serves as a consumer device for helping the visually impaired people to travel safely.
Upflow anaerobic clarification tank (UACT) to upgrade existing anaerobic effluents (2009)

The Upflow Anaerobic Clarification Tank (UACT) is of interest as a post-treatment step for high-rate anaerobic wastewater treatment systems. The UACT contributes to extra capture of methane from the raw wastewater. It also significantly facilitates the reuse of the treated water. The efficiency of the UACT process is demonstrated in this study using laboratory-scale reactors. The water produced by the UACT had a low total COD, in most cases below 145 mg/L and a soluble COD below 60 mg/L at surface loading rates between 0.1-0.4 m(3)/(m(2) h) and hydraulic retention times between 5-6 h. The sludge bed of the UACT was characterised by 6-10 times higher substrate affinity (for ethanol, acetate and propionate) compared to the parent UASB and similar specific activity. The results suggest that a UASB followed by the UACT can, upon subsequent application of a rapid filtration, qualify as a total COD removal, no longer necessitating aerobic treatment.
Miniature integrated-optic beam splitter in AlGaAs/GaAs ridge waveguides (1987)

In optical integrated circuits for communication and optical signal processing applications, it is desirable to have beam splitters or directional couplers in semiconductors to combine or split the optical signal. The two common approaches for implementing this are by the use of dual-channel waveguide couplers and V-couplers. These techniques, however, usually require 0.5-1cm device lengths which are prohibitively large for optical integration. Recently, totally reflecting waveguide mirrors have been fabricated In single- mode n/n+ GaAs rib waveguides to change the light propagation direction by 90°.1 Small size and low insertion loss have been demonstrated. Here we report a micron-size beam splitter in AlGaAs/GaAs ridge waveguides.
An Evaluation of Ultra Wideband Technology for Indoor Ranging (2006)

Abstract — Ultra wideband technology shows promise for precision ranging due to its fine time resolution to resolve multipath fading and the presence of lower frequencies in the baseband to penetrate walls. While a concerted effort has been conducted in the extensive modeling of the indoor UWB channel in recent years, to our knowledge only two papers have reported ranging performance, but for limited range and fixed bandwidth and center frequency. In principle boosting power can guarantee connectivity between transmitter and receiver, but not precision due to the distorting effects of walls and other objects in the direct path. In order to gauge the limits of UWB ranging, we carry out 5000 measurements up to an unprecedented 45 m in non line-ofsight conditions in four separate buildings with dominant wall material varying from sheet rock to steel. In addition, we report performance for varying bandwidth and center frequency of the system. Index Terms — Channel modeling, frequency domain, vector network analyzer I.