gebhart/patrepeval huggingface dataset:
Precipitation During Controlled Cooling of Magnesia‐Partially‐Stabilized Zirconia (1986)

A study has been made of the precipitation and growth processes which occur during cooling from solution treatment and under isothermal hold conditions in a magnesia‐partially‐stabilized zirconia alloy. Three types of precipitate have been identified which develop during cooling or during isothermal hold treatments just above and below the eutectoid temperature. These precipitate forms are termed (i) primary, (ii) large random, and (iii) secondary. Further precipitation, slow growth of existing precipitates, and subeutectoid decomposition result when an additional 1100°C aging treatment is given to the previously cooled material. It is shown that type (iii) secondary precipitates form rapidly within the temperature range of 1300° to 1375°C. The secondary precipitates are largely responsible for the improved room‐temperature strength properties of the heat‐treated samples. The formation and effects on mechanical properties of each type of precipitate are discussed.
Inner Ear Protein as a Biomarker in Circulation? (2014)

Serum biomarkers detect the earliest events in disease, monitor management, and provide insight into disease pathogenesis. At this time, there are no biomarkers available for otologic disorders. Otolin-1 is a scaffolding protein exclusively expressed in otoconia and cells of the vestibule and the cochlea; therefore, it may be a biomarker candidate for assessing the health of the inner ear. As a proof of concept, we used serum samples from controls without otologic history and subjects with a history of benign paroxysmal positional vertigo (BPPV), performed enzyme-linked immunosorbent assay for otolin-1, and measured the optical density of the substrate. Otolin-1 was detectable and quantifiable in all subjects, indicating that this inner ear protein crosses the blood-labyrinthine barrier. Furthermore, subjects with BPPV had significantly higher levels, with about one-third being above the control range. This promising preliminary result suggests that inner ear-specific proteins have the potential to serve as biomarkers for otologic disease processes.
Anatomically-Aware, Automatic, and Fast Registration of 3D Ear Impression Models (2006)

We present a registration framework based on feature points of anatomical, 3D shapes represented in the point cloud domain. Anatomical information is utilized throughout the complete registration process. The surfaces, which in this paper are ear impression models, are considered to be similar in the way that they possess the same anatomical regions but with varying geometry. First, in a shape analysis step, features of important anatomical regions (such as canal, aperture, and concha) are extracted automatically. Next these features are used in ordinary differential equations that update rigid registration parameters between two sets of feature points. For refinement of the results, the GCP algorithm is applied. Through our experiments, we demonstrate our technique's success in surface registration through registration of key anatomical regions of human ear impressions. Furthermore, we show that the proposed method achieves higher accuracy and faster performance than the standard GCP registration algorithm.
High-power beryllium target for use in accelerator-based born neutron capture therapy (1997)

Ongoing research at the Massachusetts Institute of Technology`s Laboratory for Accelerator Beam Applications (LABA) has focused on various components necessary for the development of accelerator-based boron neutron capture therapy (ABNCT) as a viable clinical modality. The success of ABNCT requires (a) an accelerator that can reliably generate proton or deuteron beams of several milliamperes at energies of a few mega-electron-volts and (b) a target capable of producing a sufficient neutron flux while withstanding heat loads generated by the deposition of tens of kilowatts of charged particles.
Genetic linkage between Von Hippel—Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus (1993)

Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome characterised by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma and phaeochromocytoma. The gene for VHL disease has been mapped to chromosome 3p25-p26 and presymptomatic diagnosis using linked DNA markers is available. We have previously mapped the VHL disease gene to a 4 cM interval between D3S1250 and D3S18. To increase access to presymptomatic diagnosis and to accelerate progress towards isolating the VHL disease gene we attempted to identify microsatellite DNA markers linked to the disease gene by genetic linkage analysis in 29 families. We found significant linkage between the VHL disease gene and dinucleotide (CA) repeat polymorphisms at D3S1038 (Zmax = 22.24 at theta = 0.01, CI 0.0001-0.06), D3S1110 (Zmax = 11.32 at theta = 0.07, CI 0.03-0.14) and D3S651 (Zmax = 7.73 at theta = 0.04, CI 0.008-0.13). We localised D3S1038 between D3S1250 and D3S601, and mapped D3S1110 and D3S651 centromeric to D3S1250. Multipoint linkage analysis mapped the VHL disease locus between D3S1038 and D3S18 with the maximum likelihood at D3S601. There was no evidence of locus heterogeneity. This study has (i) identified three microsatellite DNA markers in chromosome 3p25 linked to the VHL disease gene and (ii) narrowed the target region for the isolation of the VHL disease gene by positional cloning techniques. These findings will improve the management of families with VHL disease by improving the accuracy and availability of presymptomatic diagnosis using linked DNA markers, and will accelerate progress towards isolating the VHL disease gene.
Diver heating using hydrogen catalytic reactions (2002)

A simple hydrogen catalytic combustion heater for divers is described consisting of a canister filled with a chemical catalyst including precious metals such as platinum or palladium deposited on a support matrix of porous carbon particles. A small percentage of hydrogen is injected into an oxygen-rich (nitrox or heliox) gas mixture prior to passing it through the catalyst bed. As the gas mixture flows through the canister the catalyst facilitates the reaction of hydrogen with a small amount of oxygen to produce water vapor and approximately 104,000 Btu's (110,000 kJ) of heat. This approach was recently tested to produce a closed, or semi-closed heating cycle to provide a hot water heating circuit to be used with thermal protection garments for divers. Preliminary analysis has shown that over 2 kilowatts of heat can be produced, sufficient heat to sustain up to 6 divers in 32/spl deg/F water, with only 25 standard cubic feet of hydrogen per hour. This paper describes the operation of this hydrogen catalytic water heater and these recent laboratory tests.
Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies (2020)

Summary Antibodies that target the glycan cap epitope on ebolavirus glycoprotein (GP) are common in the adaptive response of survivors. A subset is known to be broadly neutralizing, but the details of their epitopes and basis for neutralization is not well-understood. Here we present cryo-electron microscopy (cryo-EM) structures of several glycan cap antibodies that variably synergize with GP base-binding antibodies. These structures describe a conserved site of vulnerability that anchors the mucin-like domains (MLD) to the glycan cap, which we name the MLD-anchor and cradle. Antibodies that bind to the MLD-cradle share common features, including the use of IGHV1-69 and IGHJ6 germline genes, which exploit hydrophobic residues and form beta-hairpin structures to mimic the MLD-anchor, disrupt MLD attachment, destabilize GP quaternary structure and block cleavage events required for receptor binding. Our results collectively provide a molecular basis for ebolavirus neutralization by broadly reactive glycan cap antibodies.
Auto-EM: End-to-end Fuzzy Entity-Matching using Pre-trained Deep Models and Transfer Learning (2019)

Entity matching (EM), also known as entity resolution, fuzzy join, and record linkage, refers to the process of identifying records corresponding to the same real-world entities from different data sources. It is an important and long-standing problem in data integration and data mining. So far progresses have been made mainly in the form of model improvements, where models with better accuracy are developed when large amounts of training data is available. In real-world applications we find that advanced approaches can often require too many labeled examples that is expensive to obtain, which has become a key obstacle to wider adoption.
A nonsense mutation and exon skipping in the Fanconi anaemia group C gene (1993)

Fanconi anaemia (FA) is an autosomal recessive disorder associated with bone-marrow failure and hypersensitivity to DNA cross-linking agents. At least four complementation groups have been defined, and a cDNA which corrects the defect in group C cells (FACC) has recently been isolated. We have screened the FACC coding sequence for mutations in FA patients and found one patient to be homozygous for a nonsense mutation in exon 6 of the FACC coding sequence (R185X). Exon 6 was spliced out of a proportion of this patient's transcripts, providing further support for the proposal that nonsense mutations may alter splice site selection. Alternatively spliced transcripts which lacked exon 13 were detected in both patients and controls.
Identification and Purification of Immunosuppressive Activity in the Urine of Rats and a Human Patient Treated with Niridazole (1977)

Abstract Administration of the antischistosomal compound niridazole to mice, guinea pigs, and humans results in the suppression of several manifestations of cell-mediated immunity. Sera from animals treated with niridazole blocked the in vitro production of migration inhibitory factor (MIF) while niridazole itself was inactive, suggesting that these effects are caused by water soluble mediators. We now report that crude extracts prepared from the urine of rats and a patient receiving niridazole, but not from pretreatment control urine, similarly suppress antigen-induced inhibition of migration of peritoneal exudate cells from sensitized guinea pigs. With immunosuppressive activity monitored by the direct MIF assay, combined solvent extraction and chromatographic techniques were used to fractionate immunosuppressive activity from the urine of niridazole-treated rats and the patient; the most active fractions, purified about 100- to 1000-fold as compared to methanol-water extracts of dried voided urine, inhibited MIF production at 0.1 to 0.01 ng/ml of assay mixture. These purified fractions also showed immunosuppressive activity by an in vivo assay wherein doses as low as 1 µg/kg injected intravenously (i.v.) into mice suppressed cell-mediated granuloma formation around Schistosoma mansoni eggs. Identically purified fractions prepared from urine of rats and the patient before they received niridazole showed no immunosuppressive activity either in the MIF or in the granuloma assay systems.
An Efficient Compiler for Weighted Rewrite Rules (1996)

Context-dependent rewrite rules are used in many areas of natural language and speech processing. Work in computational phonology has demonstrated that, given certain conditions, such rewrite rules can be represented as finite-state transducers (FSTs). We describe a new algorithm for compiling rewrite rules into FSTs. We show the algorithm to be simpler and more efficient than existing algorithms. Further, many of our applications demand the ability to compile weighted rules into weighted FSTs, transducers generalized by providing transitions with weights. We have extended the algorithm to allow for this.
Cultivation of Corneal Endothelial Cells on a Pericellular Matrix Prepared from Human Decidua-Derived Mesenchymal Cells (2014)

The barrier and pump functions of the corneal endothelium are essential for the maintenance of corneal transparency. Although corneal transplantation is the only current therapy for treating corneal endothelial dysfunction, the potential of tissue-engineering techniques to provide highly efficient and less invasive therapy in comparison to corneal transplantation has been highly anticipated. However, culturing human corneal endothelial cells (HCECs) is technically difficult, and there is no established culture protocol. The aim of this study was to investigate the feasibility of using a pericellular matrix prepared from human decidua-derived mesenchymal cells (PCM-DM) as an animal-free substrate for HCEC culture for future clinical applications. PCM-DM enhanced the adhesion of monkey CECs (MCECs) via integrin, promoted cell proliferation, and suppressed apoptosis. The HCECs cultured on the PCM-DM showed a hexagonal morphology and a staining profile characteristic of Na⁺/K⁺-ATPase and ZO-1 at the plasma membrane in vivo, whereas the control HCECs showed a fibroblastic phenotype. The cell density of the cultured HCECs on the PCM-DM was significantly higher than that of the control cells. These results indicate that PCM-DM provides a feasible xeno-free matrix substrate and that it offers a viable in vitro expansion protocol for HCECs while maintaining cellular functions for use as a subsequent clinical intervention for tissue-engineered based therapy of corneal endothelial dysfunction.
A load-instruction unit for pipelined processors (1993)

A special-purpose load unit is proposed as part of a processor design. The unit prefetches data from the cache by predicting the address of the data fetch in advance. This prefetch allows the cache access to take place early, in an otherwise unused cache cycle, eliminating one cycle from the load instruction. The prediction also allows the cache to prefetch data if they are not already in the cache. The cache-miss handling can be overlapped with other instruction execution. It is shown, using trace-driven simulations, that the proposed mechanism, when incorporated in a design, may contribute to a significant increase in processor performance. The paper also compares different prediction methods and describes a hardware implementation for the load unit.
Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument (2017)

Current clinical tools provide critical information about ocular health such as intraocular pressure (IOP). However, they lack the ability to quantify tissue material properties, which are potent markers for ocular tissue health and integrity. We describe a single instrument to measure the eye-globe IOP, quantify corneal biomechanical properties, and measure corneal geometry with a technique termed applanation optical coherence elastography (Appl-OCE). An ultrafast OCT system enabled visualization of corneal dynamics during noncontact applanation tonometry and direct measurement of micro air-pulse induced elastic wave propagation. Our preliminary results show that the proposed Appl-OCE system can be used to quantify IOP, corneal biomechanical properties, and corneal geometry, which builds a solid foundation for a unique device that can provide a more complete picture of ocular health.
Synthesis of <sup>18</sup>F-Tetrafluoroborate via Radiofluorination of Boron Trifluoride and Evaluation in a Murine C6-Glioma Tumor Model (2016)

A rapid, practical, and high-specific-activity synthesis of the NIS reporter probe (18)F-TFB was achieved via direct radiofluorination on BF3 using an automated synthesis system. The synthesis of high-specific-activity (18)F-TFB should enable future clinical studies with hNIS gene reporter viral constructs.
Simultaneous, Synergistic Control of Ion Exchange Capacity and Cross-Linking of Sterically-Protected Poly(benzimidazolium)s (2016)

The application of highly charged anion exchange membranes is often limited by strong water sorption leading to excessive swelling and eventual dissolution, especially at elevated temperatures. The cross-linking of polymers has been shown to be an excellent mitigation strategy but this often restricts membrane and ionomer processing methods. Here, we explore the reaction, stability, and utility of a cross-linking agent for the recently discovered class of cationic polymers: methylated, C2-protected poly(benzimidazolium)s. In situ reaction and formation of p-xylyl cross-linking groups is found to provide novel, highly functionalized, hydroxide-stable membranes and films with enhanced anion conductivities and superior mechanical properties compared to un-cross-linked polymers. The versatility of this strategy will be important in the design of polymers for the preparation of stable, hydroxide-conducting films, membranes, and ionomers.
Exploring Content Features for Automated Speech Scoring (2012)

Most previous research on automated speech scoring has focused on restricted, predictable speech. For automated scoring of unrestrict-ed spontaneous speech, speech proficiency has been evaluated primarily on aspects of pro-nunciation, fluency, vocabulary and language usage but not on aspects of content and topi-cality. In this paper, we explore features repre-senting the accuracy of the content of a spoken response. Content features are generated us-ing three similarity measures, including a lex-ical matching method (Vector Space Model) and two semantic similarity measures (Latent Semantic Analysis and Pointwise Mutual In-formation). All of the features exhibit moder-ately high correlations with human proficien-cy scores on human speech transcriptions. The correlations decrease somewhat due to recog-nition errors when evaluated on the output of an automatic speech recognition system; how-ever, the additional use of word confidence s-cores can achieve correlations at a similar lev-el as for human transcriptions. 1
Study of a Super-Resolution Optical Structure: Polycarbonate/ZnS–SiO<sub>2</sub>/ZnO/ZnS–SiO<sub>2</sub>/Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub>/ZnS–SiO<sub>2</sub> (2003)

A new super-resolution near-field optical structure was demonstrated. The structure, polycarbonate/ZnS–SiO2(130 nm)/ZnO(15 nm)/ZnS–SiO2(30 nm)/Ge2Sb2Te5(15 nm)/ZnS–SiO2(20 nm), has the ability in recording the small marks beyond the diffraction limit. At a readout power of 5 mW, the carrier to noise ratio (CNR) of more than 33 dB was measured for the recorded marks with the size of 100 nm by a digital versatile disc (DVD) tester. Transmission electron microscope (TEM) images of such structure displayed local orderly nanograins in 15 nm ZnO thin film. Ensemble effects of these ZnO nanostructures of the active layer are the key of the near-field super-resolution.
Electrostatic Aberration Correction in LV-SEM (2000)

Abstract The resolution of a low-voltage electron microscope is limited by the chromatic and spherical aberration of the objective lens, see Fig. 1. The design of state-of-the-art objective lenses is optimised for minimal aberrations. Any significant improvement of the resolution requires an aberration corrector. Recently, correction of both Cc and Cs has been demonstrated in SEM, using a combination of magnetic and electrostatic quadrupoles and octupoles (Zach and Haider, 1995). The present paper presents an alternative design, which is based on a purely electrostatic concept, potentially simplifying the ease-of-use of an aberration corrected microscope. In 1936 Scherzer showed that the fundamental lens aberrations of round lenses are positive definite, in absence of time-varying fields and/or space charge. Negative lens aberrations, required for the correction of Cc and Cs, can only be obtained using non-round lenses, e.g. quadrupoles and octupoles (Scherzer, 1947).
Coverage in multi-antenna two-tier networks (2009)

In two-tier networks comprising a conventional cellular network overlaid with shorter range hotspots (e.g. femtocells, distributed antennas, or wired relays) with universal frequency reuse, the near-far effect from cross-tier interference creates dead spots where reliable coverage cannot be guaranteed to users in either tier. Equipping the macrocell and femtocells with multiple antennas enhances robustness against the near-far problem. This work derives the maximum number of simultaneously transmitting multiple antenna femtocells meeting a per-tier outage probability constraint. Coverage dead zones are presented wherein cross-tier interference bottlenecks cellular and femtocell coverage. Two operating regimes are shown namely 1) a cellular-limited regime in which femtocell users experience unacceptable cross-tier interference and 2) a hotspot-limited regime wherein both femtocell users and cellular users are limited by hotspot interference. Our analysis accounts for the per-tier transmit powers, the number of transmit antennas (single antenna transmission being a special case) and terrestrial propagation such as the Rayleigh fading and the path loss exponents. Single-user (SU) multiple antenna transmission at each tier is shown to provide significantly superior coverage and spatial reuse relative to multiuser (MU) transmission. We propose a decentralized carrier-sensing approach to regulate femtocell transmission powers based on their location. Considering a worst-case cell-edge location, simulations using typical path loss scenarios show that our interference management strategy provides reliable cellular coverage with about 60 femtocells per cell-site.
Abstract 089: Dopamine D <sub>2</sub> Receptor is Associated with Inverse Salt Sensitivity (2016)

Our previous studies of salt sensitivity of blood pressure have demonstrated that approximately 11% of study participants have a paradoxical increase in blood pressure (> or = to 7-mm Hg) on a low NaCl diet (defined as inverse salt sensitivity (ISS)). However the mechanisms responsible for this effect are not known. We demonstrated that single nucleotide polymorphisms (SNPs) in the dopamine type 2 receptor (D 2 R) (RS6276 and 6267) are highly associated with ISS ( P values of 1.0х10 –2 and 3.8х10 –2 with odds ratios of 0.32 and 0.48 in unadjusted regression models, respectively). The C allele at both sites confers protection. The D 2 R is strongly expressed throughout the cytoplasm of proximal tubule cells in human kidney tissue slices. We also cultured RPTC from the urine from 4 salt resistant (SR) and 3 ISS participants enrolled in our clinical salt sensitivity studies. We hypothesize that D 2 R containing SNPs have altered receptor expression, and altered signaling compared to wild type controls. ISS participants were homozygous variant for the two D 2 R alleles and showed more D 2 R expression than SR RPTC heterozygous variant (HV) for the two alleles (ISS: 1.166±0.059 n=3 vs SR: 0.969±0.024 n=4, P<0.05, t-test). D 2 R expression was increased when the ISS cells were stimulated by a non-selective D 2 R agonist bromocriptine to a greater extent in the D 2 R SNP cell lines (ISS: VEH 1.166±0.059, vs bromocriptine 1.474 ± 0.040, n=3, P<0.05, t-test). Using the ROS reagent assay, dihydroethidium, there was found to be more ROS products in ISS cells than SR cells when stimulated under low salt (ISS: 1.145 ± 0.053, n=3 vs SR: 0.722 ± 0.101, n=4, P<0.05, t-test). We used a highly selective D 2 R agonist (sumanirole) to stimulate wild-type and SNPed cells, and the results demonstrated no effect in the cells with wild type D 2 R but an increase in ROS in cells heterozygous for the D 2 R SNPs (SNP: VEH 38,364±1,266, sumanirole 50,926 ± 3,310, VS WT: VEH 34,562±1,831 sumanirole 34,435 ± 1,614 RFU n=12, P<0.05, t-test) consistent with the higher expression of D 2 R found in ISS urine cells. We hypothesize that SNPs in the D 2 R lead to increased reactive oxygen species which has previously been associated with renal fibrosis and hypertension.