gebhart/patrepeval huggingface dataset:
Anisotropic Denoising of 3D Point Clouds by Aggregation of Multiple Surface-Adaptive Estimates (2019)

3D point clouds commonly contain positional errors which can be regarded as noise. We propose a point cloud denoising algorithm based on aggregation of multiple anisotropic estimates computed on local coordinate systems. These local estimates are adaptive to the shape of the surface underlying the point cloud, leveraging an extension of the Local Polynomial Approximation (LPA) - Intersection of Confidence Intervals (ICI) technique to 3D point clouds. The adaptivity due to LPA-ICI is further strengthened by the dense aggregation with data-driven weights. Experimental results demonstrate state-of-the-art restoration quality of both sharp features and smooth areas.
Real-Time Reed-Solomon Decoder (1994)

Generic Reed-Solomon decoder fast enough to correct errors in real time in practical applications designed to be implemented in fewer and smaller very-large-scale integrated, VLSI, circuit chips. Configured to operate in pipelined manner. One outstanding aspect of decoder design is that Euclid multiplier and divider modules contain Galoisfield multipliers configured as combinational-logic cells. Operates at speeds greater than older multipliers. Cellular configuration highly regular and requires little interconnection area, making it ideal for implementation in extraordinarily dense VLSI circuitry. Flight electronics single chip version of this technology implemented and available.
Resistin-Like Molecule-β in Scleroderma-Associated Pulmonary Hypertension (2009)

Scleroderma is a systemic, mixed connective tissue disease that can impact the lungs through pulmonary fibrosis, vascular remodeling, and the development of pulmonary hypertension and right heart failure. Currently, little is known about the molecular mechanisms that drive this condition, but we have recently identified a novel gene product that is up-regulated in a murine model of hypoxia-induced pulmonary hypertension. This molecule, known as hypoxia-induced mitogenic factor (HIMF), is a member of the newly described resistin gene family. We have demonstrated that HIMF has mitogenic, angiogenic, vasoconstrictive, inflammatory, and chemokine-like properties, all of which are associated with vascular remodeling in the lung. Here, we demonstrate that the human homolog of HIMF, resistin-like molecule (RELM)-beta, is expressed in the lung tissue of patients with scleroderma-associated pulmonary hypertension and is up-regulated compared with normal control subjects. Immunofluorescence colocalization revealed that RELM-beta is expressed in the endothelium and vascular smooth muscle of remodeled vessels, as well as in plexiform lesions, macrophages, T cells, and myofibroblast-like cells. We also show that addition of recombinant RELM-beta induces proliferation and activation of ERK1/2 in primary cultured human pulmonary endothelial and smooth muscle cells. These results suggest that RELM-beta may be involved in the development of scleroderma-associated pulmonary hypertension.
Personalization of an Online Handwriting Recognition System (2006)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et a ̀ la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
On the numerical computation of the acoustic radiation force generated by a modulated sound field (2011)

The acoustic radiation force (ARF), which signifies the average transfer of momentum from the sound wave to the propagating medium, is nowadays frequently used to compute the mean displacement field in soft tissues due to the action of a focused ultrasound beam. In situations when the sound field used to generate the ARF is modulated, the latter depends on both spatial and temporal derivatives of the acoustic intensity. Unfortunately, the numerical computation of the nonlinear acoustic solution due to modulated focused ultrasound beam is complicated by the presence of two disparate time scales in the formulation. To deal with the problem, the KZK-type spatial scaling is complemented by its dual-time-scale companion, where the temporal coordinate is split into its “fast” and “slow” components, allowing one to track the ultrasound-scale oscillations and modulation-scale variations separately in the solution. In this case, the nonlinear acoustic solution (and consequently the ARF) can be effectively computed in the “fast” frequency domain and “slow” time domain for any given modulation envelope, transient, or steady-state. The proposed developments are both validated by the experimental results and illustrated via numerical examples that show the effectiveness of the computational scheme.
Integrated vectorcardiogram (iVCG) rotation modeling and compensation (2015)

We are designing an integrated wireless Vectorcardiogram (iVCG) that is portable and worn on the chest of the patient and is capable of continuously recording and transmitting the heart vector, which is a comprehensive measure of the electrical activity of the heart. The VCG contains the same information as the classic electrocardiogram (ECG). Although a physician or trained technician will initially install the iVCG device in the appropriate position, it is prone to subsequent rotation errors introduced by the patient placement of the device. In this paper we characterize the rotation errors and present a software solution to correct the effect of the rotation error on the iVCG signals.
USE OF MIGRATORY CORROSION INHIBITORS. THE MFP SYSTEM (1997)

Migratory corrosion inhibition can extend the service life of reinforced concrete where corrosion of the steel reinforcement is occurring or likely to occur. The surface applied inhibitor is well suited to inadequate cover situations where distances for penetration to the steel are less than 50 mm. The action of sodium monofluorophosphate (MFP) was discovered in 1985 and is now becoming accepted in the commercial market place. Over 75,000 sq.m of concrete has been successfully treated since 1993. The corrosion inhibition action of MFP and the additional beneficial actions of MFP on the concrete are described and supported by extracts from the research work undertaken. The method of application and quality control is described and selected projects are summarised. For the covering abstract see ITRD E111699.
A spiral frequency steerable acoustic transducer for SHM (2011)

A Frequency Steerable Acoustic Transducer (FSAT) is proposed for directional sensing of guided waves. The considered FSAT design is characterized by a spiral configuration in wavenumber domain, which leads to a spatial arrangement of the sensing material producing output signals whose dominant frequency component is uniquely associated with the direction of incoming waves. The resulting spiral FSAT can be employed both for directional sensing and generation of guided waves, without relying on phasing and control of a large number of channels. The analytical expression of the shape of the spiral FSAT is obtained through the theoretical formulation for continuously distributed active material as part of a shaped piezoelectric device. Testing is performed by forming a discrete array through the points of the measurement grid of a Scanning Laser Doppler Vibrometer. The discrete array approximates the continuous spiral FSAT geometry, and provides the flexibility to test several configurations. The experimental results demonstrate the strong frequency dependent directionality of the spiral FSAT and suggest its application for frequency selective acoustic sensors, to be employed for the localization of broadband acoustic events, or for the directional generation of Lamb waves for active interrogation of structural health.
Frequent DNA methylation of MiR‐129‐2 and its potential clinical implication in hepatocellular carcinoma (2013)

Hepatocellular carcinoma (HCC) is a highly malignant tumor with poor prognosis and high mortality due to a lack of effective medical treatment and apparent early stage symptoms. Understanding molecular mechanism of cancer development is crucial for HCC diagnosis, prognosis, and treatment. Recently, microRNAs have been shown to play an important role in carcinogenesis, being regulated by DNA methylation in several cases. In this study, a whole genome approach was used to identify methylation-regulated miRNAs in HCC, finally focusing on miR-129-2. MiR-129-2 methylation and reduced expression were observed in all examined HCC cell lines but not in normal liver cells and tissues. In 39 (93%) of 42 HCC, the methylation levels of miR-129-2 were significantly increased in tumor tissues compared with adjacent normal tissues. Furthermore, miR-129-2 methylation was detectable in plasma samples from HCC patients, but not in plasma samples from healthy individuals or patients with liver cirrhosis. At a cut-off value of -2.36 (log2 transformation of methylation level), it was possible to distinguish HCC from healthy and cirrhotic controls with sensitivity and specificity of 88% and 100%, respectively. This study indicates that miR-129-2 methylation is highly accurate in distinguishing HCC patients from cirrhosis patients and healthy individuals, implying its potential utility as an early diagnostic marker for HCC.
Inverse problem approaches for stationary Fourier transform spectrometers (2011)

A design of a miniaturized stationary Fourier transform IR spectrometer has been developed that produces a two-dimensional interferogram. The latter is disturbed by effects like parasitic interferences or disparities in the cutoff wavelength of the pixels. Thus, a simple Fourier transform cannot be used to estimate the spectrum of the scene. However, as these defects are deterministic, they can be measured and taken into account by inversion methods. A regularization term can also be added. The first experimental results prove the efficiency of this processing methodology.
A phase modulating homodyne interferometer with tilting error compensation by use of an integrated four-photodetector (2019)

The tilting error of the measuring reflector moving with the measured object influences the accuracy of displacement measurement in laser interferometers. To solve this problem, a phase modulating homodyne interferometer with tilting error compensation is proposed for precision displacement measurement. In this interferometer, the displacement and tilting angle of the measured object are obtained simultaneously by differentially processing the phase changes of four interference signals detected with an integrated four-photodetector, and the obtained tilting angle is used to compensate its influence on the displacement result. The optical configuration of this interferometer is designed, and the displacement measurement with tilting error compensation is presented. An experimental setup is constructed, and the feasibility and effectiveness of the proposed interferometer are demonstrated.
Using Patent Citation Indicators to Manage a Stock Portfolio (2006)

This paper examines the relationship between indicators of technology quality and stock market performance. The purpose of this analysis is to demonstrate how quantitative R&D and technology indicators may be useful tools in the analysis of the stock market. Currently many stock market analysts do not include quantitative technology indicators in their evaluation of companies. The analysis presented in this paper shows how such indicators may be a useful addition to traditional methods of company valuation. The paper describes CHI’s technology value model, and presents the results of this model in terms of stock market returns. The results are divided into three sections, according to how often the model is updated. A comparison is made between portfolios updated on an annual, monthly, and weekly basis. The last of these portfolios is based on an actual investment made by CHI using part of its pension fund. The results of the analysis show that updating the model more often than annually improves its performance. This may be owed to the ability to adjust for price changes in stocks during each year.
Antiresonant Hollow Core Fibre with 0.65 dB/km Attenuation across the C and L Telecommunication Bands (2019)

We report a hollow core Nested Antiresonant Nodeless Fibre (NANF) with a loss of 0.65dB/km across the full C and L telecommunication bands. The fabricated fibre is 1.23km long, it is effectively single moded over sufficiently long lengths, and is able to transmit data.
A conceptual model for soil moisture estimation and downscaling based on topographic attributes (2011)

Soil moisture is a key state variable in land surface-atmospheric interactions, strongly influencing radiation and precipitation partitioning and thus many components of the hydrologic cycle. However, physical and economic constraints make measurement of soil moisture patterns with adequate spatial resolutions and spatial extents impractical. In particular, available remote- sensing methods produce soil moisture patterns that have relatively coarse spatial resolutions. This research presents a conceptual model that is based on representations of the processes that control soil moisture and is designed to downscale coarse-resolution soil moisture patterns using topographic data. The model assumes that soil moisture at any given location is in equilibrium with the local climate, which is represented by the available spatial-average soil moisture and a potential evapotranspiration rate. The model includes infiltration, lateral unsaturated flow, groundwater recharge, and evapotranspiration. The spatial variations in soil moisture that are produced by these processes are ultimately represented by a collection of indices derived from topographic attributes. The final model includes six parameters that are related to soil and vegetation characteristics and require calibration. In this work, the model is calibrated using soil moisture data from multiple catchments in different climatic settings. We explore the differences in parameter values from different calibration schemes as well as the model performance at each catchment. The model performance is also compared to other available downscaling methods. The results indicate that the current model's performance is comparable to other methods. However, the model's flexibility means that it is more easily calibrated with limited data, and it can more readily accept additional sources of information if available.
Towards the control of a powered orthosis for people with muscular dystrophy (2001)

The paper describes the development of a passive/active orthosis for people with limited anti-gravity strength in their arms. This is symptomatic of conditions such as muscular dystrophy and spinal muscular atrophy. A passive orthosis was designed and developed using linear elastic elements. The system is being tested with children with disabilities and preliminary results are encouraging. An RT200 robot was also used as a test-bed for an active orthosis. The robot was instrumented with a six-axis force/torque sensor at the end-effector. The force acted as the input to the robot. The robot kinematics and dynamics were modelled. A number of control schemes were implemented on the test-bed including force proportional to velocity and acceleration; these schemes were evaluated with two subjects.
Expression of <i>Vav1-Myo1F</i> Fusion Affects T-Cell Differentiation and Induces T-Cell Lymphoma (2020)

Peripheral T-cell lymphomas (PTCL) are highly aggressive, malignant hematologic tumors that arise from clonal proliferation of mature T-cells. Among these, angioimmunoblastic T-cell lymphoma (AITL), and peripheral T cell lymphomas not otherwise specified (PTCL, NOS) account for &gt;45% diagnoses, show limited response to intensified chemotherapy treatment and are associated with dismal survival. Genomic studies from our group have uncovered recurrent mutations and novel cancer-associated gene fusions involving the guanine nucleotide exchange factor VAV1 in AITL and PTCL, NOS. Interestingly, mutation co-occurrence analysis in AITL and PTCL, NOS showed significant mutual exclusivity of VAV1 genomic alterations and the highly prevalent RHOA mutations (p-value 0.0142), supporting a common mechanism of action. Gene fusions involving VAV1 are characterized by the substitution of their auto-inhibitory C-terminal SH3 domains by different domains from their fusion partners, leading to increased activation of VAV1-dependent signaling pathways. Among them, the VAV1-MYO1F fusion shows the strongest increase in VAV1 activity and activation of the mitogen-activated protein kinase (ERK1/2), c-Jun N-terminal kinase (JNK) and nuclear factor of activated T-cells (NFAT) pathways. To study the role of VAV1-MYO1F, we engineered a conditional knockin mouse that expresses the Vav1-myo1f fusion in CD4+ T-cells. Expression of Vav1-myo1f in CD4 T cells induces cell activation and alterations in T-cell specification, associated with up-regulation of master transcription factors involved in helper T-cell cell differentiation. Moreover, Vav1-Myo1f increased CD4+ T-cell survival upon cytokine withdrawal and enhanced Vav1 phosphorylation and activation of the MAPK pathway, resulting in increased cell activation and proliferation both in vivo and in vitro in response to TCR engagement. Notably, expression of Vav1-Myo1f fusion in CD4+ T-cells is sufficient to induce development of fatal malignant lymphomas with a latency of 6-14 months. Histological examination showed disrupted splenic architecture associated with clonal expansion of CD4+ cells indicative of T-cell lymphoma with PTCL, NOS phenotype. Similar results were obtained in a genetic model that combined the expression of Vav1-myo1f with the deletion of the Tet2 epigenetic regulator. In both genetic models, tumor cells specifically present a memory cell-associated immunophenotype (CD44+ CD62L-) and characteristic Th2-like features including increased expression of the transcription factors Gata3 and c-Maf and the IL4 and Il10 cytokines. Overall, these results demonstrate a direct oncogenic role for Vav1-Myo1f in the pathogenesis of PTCL, associated with deregulation of T-cell specification and of signaling programs critical for the control of T-cell proliferation. Disclosures Palomero: Kura Onclology: Research Funding.
Chemical adjuvant cryosurgery with antifreeze proteins (1997)

This preliminary study demonstrates that antifreeze proteins may be effective chemical adjuvants to cryosurgery.
Improved mechanical properties and microstructural development of microwave sintered copper and nickel steel PM parts (2005)

The application of microwave technology to a diverse range of materials and processes has resulted in a wide spectrum of materials that are commercially processed using microwaves, from the heating of food to the vulcanisation of rubber to the sintering of specialty ceramics. Microwave sintering of elemental or alloy metal powders has gained significance in recent times as a novel processing method since it offers many advantages over the conventional sintering method. Despite substantial R&D investment in this area in the past two decades, no competitive microwave technology has yet emerged for powder metallurgy (PM) sintering. In sharp contrast, because it is ‘obvious’ that microwaves are reflected by metals, it is not uncommon to be unable to locate many journal papers or literature, wherein metal powders have been sintered in a microwave field. This paper reports the improved mechanical properties and microstructural development of microwave sintered copper and nickel steel PM parts as compared with that obtained using conventional sintering technique. The paper describes the fabrication details of the FC-0208 and FN-0208 composition steel PM parts, and the in house modified commercial microwave oven used for sintering. Microwave sintering resulted in higher sintered density and improved mechanical properties for both Cu and Ni steel PM parts as compared with that processed using conventional sintering under identical conditions. The improved mechanical properties can be attributed primarily to more uniform distribution of the alloying elements, which resulted in greater material homogeneity at the nano- and microlevels as revealed by the Cu and Fe X-ray maps using high spatial resolution scanning transmission electron microscopy (STEM). The optical micrographs of both the etched and unetched samples clearly showed development of novel sintered microstructures having distinct characteristics for the porosity distributions: smooth and rounded pores with low stress concentration regions for microwave sintering as against sharp, triangular and wedge shaped pores with high stress concentration regions for conventional sintering.
Semiconductive metal oxide ferroelectric memory transistor: A long-retention nonvolatile memory transistor (2005)

The retention problem is a technical challenge for one-transistor (1T) ferroelectric memory devices. Three possible mechanisms are responsible for the poor retention of one-transistor ferroelectric memories: namely, charges trapping within the gate oxide and ferroelectric film, floating gate effect, and the depolarization field. In order to overcome these problems, a novel ferroelectric transistor design using a semiconductive oxide film in place of the gate dielectric has been fabricated. There is no insulator, other than the ferroelectric thin film in the gate stack; therefore, there is a very low depolarization field. The bottom gate of the ferroelectric capacitor is electrically connected to the silicon substrate through the semiconductive metal oxide resulting in the improvement of the memory retention characteristics.
Electron–Nuclear Spin Interaction in Edge States of Quantum Hall Systems (2003)

We have studied the electron–nuclear spin interaction in integer and fractional quantum-Hall edge channels. By selectively populating edge channels of different spin polarities, nuclear spins along the edge channels are dynamically polarized through the hyperfine interaction. The resultant dynamic nuclear polarization is detected with the edge-channel transport via nuclear magnetic resonance. The technique of controlling and detecting nuclear–spin polarization in quantum-Hall systems opens up new possibilities of developing nuclear–spin solid-state devices as well as shedding new light to spin properties of quantum-Hall systems. We demonstrate local controllability of the nuclear–spin polarization using a built-in micro-metal strip fabricated on a quantum-Hall device. We also demonstrate that the dynamic nuclear polarization can be utilized as a sensitive probe of the spin polarization of fractional quantum-Hall edge channels.
Bayesian Image Super-Resolution (2002)

The extraction of a single high-quality image from a set of lowresolution images is an important problem which arises in elds such as remote sensing, surveillance, medical imaging and the extraction of still images from video. Typical approaches are based on the use of cross-correlation to register the images followed by the inversion of the transformation from the unknown high resolution image to the observed low resolution images, using regularization to resolve the ill-posed nature of the inversion process. In this paper we develop a Bayesian treatment of the super-resolution problem in which the likelihood function for the image registration parameters is based on a marginalization over the unknown high-resolution image. This approach allows us to estimate the unknown point spread function, and is rendered tractable through the introduction of a Gaussian process prior over images. Results indicate a signi cant improvement over techniques based on MAP (maximum a-posteriori) point optimization of the high resolution image and associated registration parameters.