gebhart/patrepeval huggingface dataset:
An Hsp27-related, Dominant-negative-acting Intracellular Estradiol-binding Protein (2004)

New World primates (NWPs) exhibit a compensated form of resistance to gonadal steroid hormones. We demonstrated recently that estrogen resistance in NWP cells was associated with the overexpression of two proteins, a nonreceptor-related, dominant-negative-acting estrogen response element (ERE)-binding protein (ERE-BP) and an intracellular estradiol-binding protein (IEBP). Based on the N-terminal sequences of tryptic fragments of IEBP isolated from a 17beta-estradiol (E2) affinity column we cloned a full-length cDNA for IEBP from the estrogen-resistant NWP cell line, B95-8. Subsequent sequence analysis revealed 87% sequence identity between the deduced peptide for IEBP and human Hsp27. When hormone-responsive, wild-type Old World primate (OWP) cells were transiently transfected with IEBP cDNA, E2-directed ERE reporter luciferase activity was reduced by 50% compared with vector only-transfected OWP cells (p < 0.0018). When IEBP and ERE-BP were cotransfected, ERE promoter-reporter activity was reduced by a further 60% (p < 0.0001). Electrophoresis mobility shift analyses showed that IEBP neither bound to ERE nor competed with the estrogen receptor (ER) for binding to ERE. However, there was evidence of protein-protein interaction of IEBP and ERalpha; IEBP was coimmunoprecipitated with anti-ERalpha antibody in wild-type cells stably transfected with IEBP. A specific interaction between ERalpha and IEBP was confirmed in glutathione S-transferase pull-down and yeast two-hybrid assays. Data indicate that the Hsp27-related IEBP interacts with the ligand binding domain of the ERalpha. In summary, by inhibiting the ERalpha-E2 interaction, IEBP acts to squelch ERalpha-directed ERE-regulated transactivation and promote estrogen resistance in NWP cells.
Double spin-torque magnetic tunnel junction devices for last-level cache applications (2022)

We experimentally demonstrate reliable 300 ps switching in arrays of 35 nm double spin-torque magnetic tunnel junctions (DS-MTJs), and also demonstrate a new free-layer design with improved activation energy and magnetoresistance. We establish a new method to characterize the DS-MTJ devices for materials feedback, by introducing and experimentally verifying a simple device-physics model. The model and data show that, compared to a single MTJ (SMTJ), the DS-MTJ has lower switching current, faster switching speed, and better dependence on resistance-area product (RA), meeting key requirements for last-level cache.
Reevaluation of PbTe1−xIx as high performance n-type thermoelectric material (2011)

Thermoelectric transport properties of n-type PbTe1−xIx with carrier concentrations ranging from 5.8 × 1018–1.4 × 1020 cm−3 are reinvestigated from room temperature to 800 K. The electronic transport properties, resistivity and Seebeck coefficient in this study are effectively consistent with prior reports, however the thermal conductivity has been found to be historically overestimated. The reassessment of the thermal transport properties, in combination with careful control of the carrier density by iodine doping, reveals a significantly larger figure of merit, zT ∼ 1.4, than often previously reported for n-type PbTe. The results and analysis of the data from this study lead to a redetermination of zT for this historical thermoelectric material and provide a renewed interest in n-type PbTe based materials.
Creating Antimicrobial Surfaces and Materials for Contact Lenses and Lens Cases (2007)

Contact lenses are a safe and effective mode of vision correction used by more than 100 million people worldwide, yet some adverse responses to microbial contamination of contact lenses still occur. Various medical devices, including contact lens cases, currently use antimicrobial agents to eliminate or reduce microbial contamination at the surface. The application of antimicrobial surface technologies to contact lenses and lens cases is being explored. This article describes agents that hold promise for antimicrobial surfaces for contact lenses or lens cases.
Derivation of Response Time Service Level Objectives for Business Services (2007)

Design of Service Level Agreements (SLAs) emerges as an increasingly important discipline in business-oriented IT management. In this work, we study utility maximization of contractual obligations of a business service provider for a typical SLA. We demonstrate that using service usage and performance data as well as IT performance data, routinely collected by enterprises, efficient automated derivation of optimal response time Service Level Objectives (SLOs) of an SLA is possible. This paper addresses a specific facet of the SLA design problem not sufficiently addressed in previous studies. One common approach is to calculate SLOs attainable for the given IT infrastructure by means of simple percentile analysis. However, this methodology is business agnostic and may result in sub-optimal SLOs. Another widespread approach addresses IT infrastructure (re)design, where the goal is to enable the IT to meet specified target SLOs. In contrast to these approaches, our work proposes finding optimal response lime SLOs attainable for the given IT infrastructure in a business aware manner. We define the response time SLO optimization problem, propose an algorithm that efficiently solves it using linear optimization and percentile analysis, and evaluate our solution both analytically and experimentally.
The role of biomarkers in the diagnosis of periprosthetic joint infection (2016)

The role of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first line for evaluating a patient with periprosthetic joint infection (PJI) has been debunked.We are living in the era of biomarkers for the diagnosis of PJI, and to that effect, several biomarkers have been introduced such as synovial fluid alpha defensin and leukocyte esterase.The synovial fluid leukocyte esterase test has a low cost, is accessible, and has provided promising results for diagnosing PJI.There is an urgent need for an accurate and reliable serum biomarker for diagnosing patients with PJI. Cite this article: Shahi A, Parvizi J. The role of biomarkers in the diagnosis of periprosthetic joint infection. <i>EFORT Open Rev</i> 2016;1:275-278. DOI: 10.1302/2058-5241.1.160019.
Synthetic nanocomposite MgH2/5 wt. % TiMn2 powders for solid-hydrogen storage tank integrated with PEM fuel cell (2017)

Abstract Storing hydrogen gas into cylinders under high pressure of 350 bar is not safe and still needs many intensive studies dedic ated for tank’s manufacturing. Liquid hydrogen faces also severe practical difficulties due to its very low density, leading to larger fuel tanks three times larger than traditional gasoline tank. Moreover, converting hydrogen gas into liquid phase is not an economic process since it consumes high energy needed to cool down the gas temperature to −252.8 °C. One practical solution is storing hydrogen gas in metal lattice such as Mg powder and its nanocomposites in the form of MgH 2 . There are two major issues should be solved first. One related to MgH 2 in which its inherent poor hydrogenation/dehydrogenation kinetics and high thermal stability must be improved. Secondly, related to providing a safe tank. Here we have succeeded to prepare a new binary system of MgH 2 /5 wt. % TiMn 2 nanocomposite powder that show excellent hydrogenation/dehydrogenation behavior at relatively low temperature (250 °C) with long cycle-life-time (1400 h). Moreover, a simple hydrogen storage tank filled with our synthetic nanocomposite powders was designed and tested in electrical charging a battery of a cell phone device at 180 °C through a commercial fuel cell.
Inhibition of LPS-responses by synthetic peptides derived from LBP associates with the ability of the peptides to block LBP–LPS interaction (2003)

The ability of LPS-binding protein (LBP) to greatly potentiate cell responses to lipopolysaccharide (LPS) may largely contribute to LPS toxicity in sepsis. The study of agents with the capacity to block the interaction between LBP and LPS might improve the understanding of the role of LBP in Gram-negative infections as well as offering new therapeutic tools for septic disorders. Here we confirm the ability of synthetic peptides comprising the human LBP amino acid region 86-108 to interfere with the LBP-LPS interaction. The analysis of selected alanine mutants of a blocking peptide corresponding to the LBP region 86-99 suggests the importance of peptide amphipathicity for the inhibitory activity. The potency of the native peptide and a selected analogue at inhibiting in vitro and in vivo LPS-induced responses was associated with their relative activity in blocking LBP-LPS interaction. It was remarkable that these peptides were at least 500-fold more active in vivo than in vitro. Also, the inhibitory activity of peptides LBP86-99 and LBPK95A seems to be independent of LBP concentrations, a behavior that may be relevant for the potential use of these peptides in septic disorders where LBP serum concentrations are considerably elevated.
Automated detection of shadow artifacts in optical coherence tomography angiography (2019)

Frequently, when imaging retinal vasculature with optical coherence tomography angiography (OCTA) in diseased eyes, there are unavoidable obstacles to the propagation of light such as vitreous floaters or the pupil boundary. These obstacles can block the optical coherence tomography (OCT) beam and impede the visualization of the underlying retinal microcirculation. Detecting these shadow artifacts is especially important in the quantification of metrics that assess retinal disease progression because they might masquerade as regional perfusion loss. In this work, we present an algorithm to identify shadowed areas in OCTA of healthy subjects as well as patients with diabetic retinopathy, uveitis and age-related macular degeneration. The aim is to exclude these areas from analysis so that the overall OCTA parameters are minimally affected by shadow artifacts.
HDR compression in the JVET codec (2018)

This paper presents an advanced approach to HDR/WCG video coding developed at FastVDO called FVHDR, and built on top of the Versatile Video Coding (VVC) VTM1.0 test model of the Joint Video Exploration Team, a joint committee of ITU|ISO/IEC. A fully automatic adaptive video process that differs from a known HDR video processing chain (analogous to HDR10, and herein called “anchor”) developed recently in the standards committee JCTVC, is used. FVHDR works entirely within the framework of the VTM software model, but adds additional tools. These tools can become an integral part of a future video coding standard, or be extracted as additional pre- and post-processing chains. Reconstructed video sequences using FVHDR show an improved subjective visual quality to the output of the anchor. Moreover, the resultant SDR content generated by the data adaptive grading process is backward compatible.
Surface Modification Method of Microchannels for Gas−Liquid Two-Phase Flow in Microchips (2004)

A capillarity restricted modification method for microchannel surfaces was developed for gas--liquid microchemical operations in microchips. In this method, a microstructure combining shallow and deep microchannels and the principle of capillarity were utilized for chemical modification of a restricted area of a microchannel. A hydrophobic--hydrophilic patterning in microchannels was prepared as an example for guiding gas and liquid flows along the respective microchannels. Validity of the patterning was confirmed by measuring aqueous flow leak pressure from the hydrophilic microchannel to the hydrophobic one. The leak pressure of 7.7-1.1 kPa agreed well with that predicted theoretically from the Young-Laplace equation for the microchannel depth of 8.6-39 microm. In an experiment to demonstrate usefulness and effectiveness of the method, an air bubble was first introduced into the hydrophilic microchannel and purged from the hydrophobic-hydrophilic patterned microchannels. Next, the patterning structure was applied to remove dissolved oxygen by contacting the aqueous flow with a nitrogen flow. The concentration of dissolved oxygen decreased with contact time, and its time course agreed well with numerical simulation. These demonstrations showed that the proposed patterning method can be used in general microfluidic gas-liquid operations.
Chip-level ESD simulation for fail detection and design guidance (2004)

Modern VLSI designs in deep submicron technologies constitute a new type of ESD protection challenge. Increasing complexity of modem digital and mixed signal designs demands for simulation and verification methods that guarantee, that ESD protection concepts and rules are correctly implemented and brought to silicon. A simulation approach and analysis method is presented that allows to address a class of ESD fails caused not by specific design or layout errors, but rather by an unfavourable setup of the chip supply concept and I/O cell ring. The high complexity of chip-level ESD networks is handled with a Monte-Carlo like, permutational approach. The integration of this method in the chip concept engineering and design flow is discussed.
Isolation and characterization of a new antibiotic U-62162. (1982)

A new antibiotic U-62162 has been isolated from the fermentations of Streptomyces verdensis Dietz, sp. n. (UC-8157). The compound has been characterized and its gross structure has been elucidated. The antibiotic inhibited the growth of Gram-positive bacteria (particularly Staphylococcus aureus) but was inactive in experimentally infected animals.
Curved-Slab Maximum Intensity Projection: Method and Evaluation (2003)

The authors developed and evaluated a method to produce curved-slab maximum intensity projections (MIPs) through blood vessels that semiautomatically excludes soft tissue and bone. Results obtained with the algorithm were compared with those obtained with rectangular-slab MIPs by using computed tomographic (CT) data from four patients with abdominal aortic aneurysms. Curved-slab MIPs exhibited increased mean vessel-to-perivascular tissue contrast of 55.1 HU (36%), allowed a 10% increase in contrast-to-noise ratio, and decreased apparent vessel narrowing by 0.12-1.09 mm, without increasing processing time. Curved-slab MIPs may also include multiple vessels in a single image, thereby improving interpretation efficiency by reducing the number of MIPs required in these patients from eight to three.
Xenon Attenuates Cardiopulmonary Bypass–induced Neurologic and Neurocognitive Dysfunction in the Rat (2003)

These data indicate that CPB-induced neurologic and neurocognitive dysfunction can be attenuated by the administration of xenon, potentially related to its neuroprotective effect via N-methyl-D-aspartate receptor antagonism.
Tyrosine-sulfated Peptides Functionally Reconstitute a CCR5 Variant Lacking a Critical Amino-terminal Region (2002)

Entry of most primary human immunodeficiency virus, type 1 (HIV-1) isolates into their target cells requires the cellular receptor CD4 and the G protein-coupled chemokine coreceptor CCR5. An acidic, tyrosine-rich, and tyrosine-sulfated domain of the CCR5 amino terminus plays a critical role in the ability of CCR5 to serve as an HIV-1 coreceptor, and tyrosine-sulfated peptides based on this region physically associate with the HIV-1 envelope glycoprotein gp120 and slow HIV-1 entry into CCR5-expressing cells. Here we show that the same tyrosine-sulfated peptides, but not their unsulfated analogs, can restore the HIV-1 coreceptor activity of a CCR5 variant lacking residues 2-17 of its amino terminus. Additionally, these sulfated peptides restored the ability of this CCR5 variant to mobilize calcium in response to the chemokines macrophage inflammatory factors 1alpha and 1beta. These observations show that a tyrosine-sulfated region of the CCR5 amino terminus can function independently to mediate association of chemokines and the HIV-1 envelope glycoprotein with the remaining domains of CCR5.
Building a diffractive imaging micro spectrometer (2004)

A diffractive imaging micro spectrometer that exhibits good spectral and spatial resolution is a very useful lab-on-a-chip device that can be integrated into biosensors. We have demonstrated the possibility of such a micro spectrometer experimentally. The coupled input signal was the fluorescence emanating from a miniature drop of rhodamine dye in methanol excited by Ar+-ion laser of power less than 1 mW.
Generalized nonfull-aperture Luneburg lens: a new solution (1993)

By following the basic principles of the design of nonfullaperture Luneburg lenses, a new solution, or a new family of lenses has been found. The new lens has in the outer shell the profile of a refractive index characterized as <i>n</i>=exp(<i>P</i><sup>2</sup>/<i>h</i><sup>2</sup>). In practice, each particular solution is characterized by the focal length and the value of the refractive index at the edge of the lens. The value of the refractive index at the edge can be arbitrarily selected within a certain range. This range is different for different focal lengths.
Potency of Mature CD40L RNA Electroporated Dendritic Cells Correlates With IL-12 Secretion by Tracking Multifunctional CD8+/CD28+ Cytotoxic T-cell Responses In Vitro (2010)

Electroporation of mature dendritic cells (DC) with RNA-encoding CD40L greatly enhances the production of interleukin (IL)-12, a proinflammatory cytokine necessary for the induction of T-cell immunity. Results presented herein reveal a correlation between the priming of CD28(+) antigen-reactive effector memory cytotoxic T lymphocytes (CTL) displaying 3 or 4 simultaneous effector functions and the quantity of IL-12 produced by postmaturation electroporation-CD40L DC. By using multiparameter flow cytometry, the quantities of IL-12 needed to prime naive antigen-reactive T cells to simultaneously produce interferon-γ and tumor necrosis factor-α in the presence or absence of IL-2 secretion in conjunction with lytic activity defined by CD107a expression can be used to determine the overall potency of a DC product. In the presence of IL-12, CTL differentiation toward lytic function is not accompanied by a reduction in the secretion of interferon-γ and tumor necrosis factor-α. Therefore, by measuring the availability of IL-12 one can predict the potency of a DC immunotherapeutics in relation to its ability to drive distinct effector memory CTL subsets with multifunctional activities.
Advanced Reservoir Evaluation Using Downhole Fluid Analysis and Asphaltene Flory-Huggins-Zuo Equation of State (2013)

Understanding reservoir complexities such as compartmentalization and compositional gradients early on is crucial for optimal field development, especially in deepwater environments. Downhole fluid analysis (DFA) measures composition, gas/oil ratio (GOR), density, optical density (linearly associated with asphaltene content), and fluorescence intensity. Based on the Yen-Mullins model of asphaltene science and DFA measurements, the industry's first predictive asphaltene equation of state, the Flory-Huggins-Zuo (FHZ) EOS has been developed. It has been successfully used to estimate asphaltene concentration (optical density, OD) gradients and help predict reservoir connectivity ― subsequently proven by production data. This provides an advanced reservoir evaluation tool, which reduces uncertainty in reservoir characterization. In this paper, DFA and the FHZ EOS were used to analyze two case studies: The first deals with a black oil column with a steep asphaltene gradient while the second deals with a light (near critical) oil with a large compositional gradient. For the black oil column, detailed analysis of recently available pressure data suggests that this oil column is disconnected from the aquifer and from the regional pressure regime. For the light oil column, five DFA stations were conducted. The delumping technique (Zuo et al., 2011) was used to obtain compositions from the DFA data, which compared well with gas chromatography data. The cubic EOS was applied to describe the large variations observed in composition, gas/oil ratio (GOR) and density. The obtained results were also in good agreement with the measurements. Because of very low optical absorption in this light oil column, the FHZ EOS was employed to analyze the fluorescence intensity gradient, which is correlated with a fraction of heavy resins. The FHZ EOS has been successfully extended to light oil with very low optical absorption but a large fluorescence intensity gradient for the first time. The results show that the heavy resin is molecularly dispersed in this light oil column, and the GOR gradient creates the fluorescence intensity (heavy resin) gradient via the solubility term of the FHZ EOS. The equilibrium heavy resin distribution suggests this oil column is connected, which is also proven by other log and production data with the latter indicating a variable mix of the end members.
Broadband monolithically-tunable quantum cascade lasers (2018)

Mid-infrared lasers, emitting in the spectral region of 3-12 μm that contain strong characteristic vibrational transitions of many important molecules, are highly desirable for spectroscopy sensing applications. High efficiency quantum cascade lasers have been demonstrated with up to watt-level output power in the mid-infrared region. However, the wide wavelength tuning, which is critical for spectroscopy applications, is still largely relying on incorporating external gratings, which have stability issues. Here, we demonstrate the development a monolithic, widely tunable quantum cascade laser source emitting between 6.1 and 9.2 μm through an on-chip integration of a sampled grating distributed feedback tunable laser array with a beam combiner. A compact tunable laser system was built to drive the individual lasers within the array and coordinate the driving of the laser array to produce desired wavelength. A broadband spectral measurement (520cm<sup>-1</sup>) of methane shows excellent agreement with Fourier transform infrared spectrometer measurement. Further optimizations have led to high performance monolithic tunable QCLs with up to 65 mW output while delivering fundamental mode outputs.
Three-dimensional remote sensing by optical scanning holography (2001)

A technique is presented by which holograms can be recorded when an object or scene is scanned with an optically heterodyned Fresnel zone pattern. The experimental setup, based on optical scanning holography, is described and experimental results are presented. We apply the scanning holography technique to three-dimensional reflective objects for the first time to our knowledge and address the unique requirements for such a system. We discuss holographic recording and numerical image reconstruction using a system point-spread function (PSF) approach. We demonstrate numerical image reconstruction of experimentally recorded holograms by two techniques: deconvolution with a simulated PSF and an experimentally acquired PSF.
Shielding of antenna parameters in scattering environments using electromagnetic cloaking (2008)

An application of electromagnetic cloaks to shielding the radiation and circuit parameter characteristics of an antenna from other objects and antennas in highly scattering environments has been presented. The blockage and loading effects of scatterers on an antenna can be eliminated by enclosing them in cloaks designed to operate at the transmitting frequency of the antenna. In multiple-antenna radiation environments, each antenna can be enclosed in an electromagnetic cloak, which is designed to operate at the frequencies of other antennas and become transparent at the operating frequency of the enclosed antenna.