gebhart/patrepeval huggingface dataset:
Minimally Invasive Flexible Insertion and Rigid Intramedullary Nail Fixation for Distal Radius Fractures (2012)

Intramedullary (IM) devices are currently available for the surgical treatment of various distal radius fractures. The proposed advantages of IM fixation include minimally invasive operative techniques, less opportunity for hardware irritation, decreased postoperative pain, and stable fixation allowing for early range of motion. However, many complications have been reported with the use of IM devices in the distal radius such as injury to the superficial branch of the radial nerve, screw penetration into the distal radial ulnar joint, and loss of reduction. Nonetheless, early clinical reports of IM fixation for purely extra-articular distal radius fractures (AO type 23-A) and those with simple intra-articular extension (AO type 23-C1 and C2) have been promising. The purpose of this article is to describe the indication, technique, and rehabilitation after IM nail fixation for select distal radius fractures with a novel IM device, which provides locked fixed angle distal screws to support the articular subchondral bone and a unique flexible IM component that conforms to the patient's anatomy, is made rigid, and locks proximally with IM fixation within the radial diaphysis. This unique device is theorized to be more patient specific (due to the flexible portion of the nail) and further minimize soft tissue irritation compared with those IM devices currently available.
The Yin and Yang of nucleic acid-based therapy in the brain (2016)

The post-genomic era has unveiled the existence of a large repertory of non-coding RNAs and repetitive elements that play a fundamental role in cellular homeostasis and dysfunction. These may represent unprecedented opportunities to modify gene expression at the right time in the correct space in vivo, providing an almost unlimited reservoir of new potential pharmacological agents. Hijacking their mode of actions, the druggable genome can be extended to regulatory RNAs and DNA elements in a scalable fashion. Here, we discuss the state-of-the-art of nucleic acid-based drugs to treat neurodegenerative diseases. Beneficial effects can be obtained by inhibiting (Yin) and increasing (Yang) gene expression, depending on the disease and the drug target. Together with the description of the current use of inhibitory RNAs (small inhibitory RNAs and antisense oligonucleotides) in animal models and clinical trials, we discuss the molecular basis and applications of new classes of activatory RNAs at transcriptional (RNAa) and translational (SINEUP) levels.
Structural health monitoring using scanning laser vibrometry: II. Lamb waves for damage detection (2004)

Guided acousto-ultrasonic waves have great potential for structural health monitoring applications. Lamb waves are the most widely used guided waves for damage detection in metallic and composite structures. These waves, once introduced to a structure, can propagate long distances. Nevertheless the method still requires a significant number of transducers for monitoring large structures. Recent years have shown various applications of non-contact generation and sensing of Lamb waves. This paper proposes a new scanning technique based on laser vibrometry. The method is applied for damage detection in simple aluminium plates and validated using numerical simulations. The study shows the potential of the method for simple and rapid detection, location and monitoring of damage in structures.
Neurological and neuropsychological examination and outcome after use of an intra-aortic filter device during cardiac surgery (2003)

Cerebral embolization of particles after cardiac surgery is frequently associated with neurological deficits. Aortic crossclamp manipulation seems to be the most significant cause of emboli release during cardiac surgery. The goal of this study was to demonstrate whether the use of an intra-aortic filter device has an effect on the magnet resonance imaging (MRI) and functional neurological outcome. Twenty-four patients undergoing cardiosurgical procedures using cardiopulmonary bypass (CPB) were selected: coronary artery bypass graft (CABG) surgery (n = 17), aortic valve replacement (AVR) surgery (n = 4) or combined procedures (n = 3). Patients were evaluated by diffusion weighted MRI of the brain, neurological examination and neuropsychological assessment regarding alertness as well as divided and selective attention before and five to seven days after surgery. The patients were divided into two groups. In group I, 12 patients received a filter through a modified 24 F arterial cannula immediately before the aortic crossclamp was released. Filters remained in the aorta until CPB was discontinued. Intraoperatively, bilateral middle cerebral artery transcranial Doppler (TCD) was monitored at baseline, at the beginning of CPB, at a timepoint when the aorta was crossclamped, when the filter was inserted and while the crossclamp was switched to partial clamping until the CPB was discontinued. TCD was used for detection of microembolic signals (MES). The captured material in the filter was examined histologically. Twelve patients served as controls without aortic filtration (group II). The MRI of the brain did not show any diffusion alterations in either group before or after surgery. No patient developed a focal neurological deficit or stroke. Intraoperative quantitative MES detection revealed a four to tenfold increase in patients of group I compared with group II (5-6 versus 0.5-1 MES/min) during the filter dwell time. There was no consistent pattern regarding the neurobehavioural sequelae. Filters showed arteriosclerotic debris in 75% of the patients. The use of the intra-aortic filter device did not show a positive effect on neurological, neuroradiographical and neuropsychological outcomes. The increase of the MES rate in group I patients may be due to microbubbles generated as microcavitations by the filter or the aortic filter cannula. The intra-aortic filter was able to capture atheromatous material in 75% of the patients.
Automatic construction of nonparametric relational regression models for multiple time series (2016)

Gaussian Processes (GPs) provide a general and analytically tractable way of modeling complex time-varying, nonparametric functions. The Automatic Bayesian Covariance Discovery (ABCD) system constructs natural-language description of time-series data by treating unknown time-series data nonparametrically using GP with a composite covariance kernel function. Unfortunately, learning a composite covariance kernel with a single time-series data set often results in less informative kernel that may not give qualitative, distinctive descriptions of data. We address this challenge by proposing two relational kernel learning methods which can model multiple time-series data sets by finding common, shared causes of changes. We show that the relational kernel learning methods find more accurate models for regression problems on several real-world data sets; US stock data, US house price index data and currency exchange rate data.
36 GHz dual-modulus prescaler in SiGe bipolar technology (2003)

Presents a dual-modulus prescaler with divide ratios of 256 and 257. The circuit uses static divider stages and differential current-mode logic. AND-gates are merged with flip-flops to achieve high operating frequencies at low power consumption. The prescaler operates with input frequencies ranging from below 1 GHz up to 36.4 GHz. It consumes 34.2 mA from a 3 V supply. The circuit is manufactured in a 0.4 /spl mu/m SiGe bipolar technology.
<i>thyA</i> as a Selection Marker in Construction of Food-Grade Host-Vector and Integration Systems for <i>Streptococcus thermophilus</i> (2004)

We constructed food-grade host-vector and integration systems for Streptococcus thermophilus by using a thymidylate synthase gene (thyA) as the selection marker. Two thyA genes, thyA(St) and thyA(Lb), were cloned from S. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus, respectively. Thymidine-requiring mutants of S. thermophilus were obtained after successive cultures in the presence of trimethoprim, and one of them, TM1-1, was used as the host. Food-grade vectors were constructed by using either thyA(St) or thyA(Lb) as the selection marker. Transformants of TM1-1 created by using these vectors were selected for thymidine autotrophy as efficiently as for erythromycin resistance. By using the host-vector system developed in this way, a foreign amylase gene (amyA) was expressed in TM1-1 and was also integrated into the chromosome by use of a temperature-sensitive integration vector constructed with thyA(Lb) as the selection marker via a double-crossover event. The results obtained show that thyA is an efficient and safe selection marker for S. thermophilus that is suitable for food applications.
Open Tubular Anion Exchange Chromatography. Controlled Layered Architecture of Stationary Phase by Successive Condensation Polymerization (2007)

The preparation and performance of a multilayered stationary phase for open tubular anion exchange chromatography in relatively large bore (75 microm diameter) columns are described. The inner surface of a fused-silica capillary tube is coated with up to 25 successive porous polymeric layers formed by condensation polymerization of a primary amine with a diepoxide. Each layer of the anion exchange stationary phase consists of copolymer of methylamine (MA) and 1,4-butanedioldiglycidyl ether (BDDE). The polymer layers are sufficiently porous or permeable; each successive layer of the stationary phase incrementally increases the observed column capacity and chromatographic performance in the open tubular mode. Even though the column inner diameter is far from optimum for open tubular liquid chromatography, we demonstrate the baseline separation of a suite of inorganic anions (F-, Cl-, NO2-, Br-, NO3-) in a 5 m x 75 microm column coated with 25 layers of the anion exchange polymer using 1 mM KOH eluent and suppressed contactless conductometric detection at a flow rate of 1 microL/min (operating pressure of approximately 1 bar) with a plate count of >30,000. Strategies for construction of microsuppressor devices used in open tubular ion chromatography are discussed.
Effect of timing and sequence of hyperthermia and cyclophosphamide on a neurogenic rat tumor (BT4A) in vivo (1983)

The interaction of hyperthermia (HT) 1 hour at 44.0 degrees C and cyclophosphamide (CP) 200 mg/kg was studied in vivo in a solid transplantable neurogenic rat tumor (BT4A) in the foot of BD IX rats. HT was given by water bath heating. When both modalities were close in time (CP immediately before HT or 1 hour before HT), an enhanced effect with complete regression and cure of tumors was seen. This could not be obtained with either modality alone. Extending the interval between treatments within 24 hours, an effect equal to the sum of each modality was obtained when HT was given before CP, while HT after CP was less effective. Timing and sequence may be critical factors for the optimal combination of HT and cytotoxic drugs.
The Simon Population Trust: A brief history (2002)

been born in Silesia, and came to Manchester in 1860 from Zurich; Emily was also German in origin. Henry built an engineering business in Manchester; both he and Emily were active in local affairs. Ernest was sent to Rugby and to Pembroke
Biochemical and Immunological Studies in Calves Living over Three Months with a Total Artificial Heart (1992)

Changes in serum proteins, enzymes and isoenzymes of lactate dehydrogenase (LDH) were compared in long-term surviving calves with a total artificial heart without influencing their central venous pressure (CVP) and calves in which CVP was lowered by antihypertensive drugs administered from day 60 to the end of the experiment. Antihypertensive drugs helped keep CVP within physiological levels for longer and aided liver function as well as evidenced by the different values for the parameters studied in the two groups.
Synthesis and characterization of silver-PDMS nanocomposite for the biosensing applications (2011)

Noble metal (Au, Ag, Pd) - PDMS composites show highly enhanced mechanical and optical properties compared with the polymer alone. Among the different methods of synthesis, the in situ "one step" preparation of these composite materials, by immersion of PDMS films into the solution of the metal salt and reduction to elemental metal is a simple and straightforward method. The metal nanoparticles are immobilized and uniformly distributed into the surface layers of the polymer and this structure proved to be suitable for biosensing purposes. Sensing is performed by measuring the position and intensity of the Localized Surface Plasmon Resonance (LSPR) band of silver in the UV-Visible spectrum of the nanocomposite. In this work, the structure and composition of Ag-PDMS nanocomposites are optimized in order to enhance the sensitivity of the sensing platform. A novel method of tuning the morphology of nanocomposite by annealing it for the desired optical property is optimized. The quality of the platform is investigated for sensing polypeptides such as hormones, through an immunoassay, by using the antigen-antibody interaction.
Lexicon Integrated CNN Models with Attention for Sentiment Analysis (2017)

With the advent of word embeddings, lexicons are no longer fully utilized for sentiment analysis although they still provide important features in the traditional setting. This paper introduces a novel approach to sentiment analysis that integrates lexicon embeddings and an attention mechanism into Convolutional Neural Networks. Our approach performs separate convolutions for word and lexicon embeddings and provides a global view of the document using attention. Our models are experimented on both the SemEval'16 Task 4 dataset and the Stanford Sentiment Treebank and show comparative or better results against the existing state-of-the-art systems. Our analysis shows that lexicon embeddings allow building high-performing models with much smaller word embeddings, and the attention mechanism effectively dims out noisy words for sentiment analysis.
Validez de contenido de un instrumento de medición de ventaja competitiva del sector hotelero (2020)

Ante los altos niveles de exigencia organizacional que dicta la globalización, generar y mantener ventaja competitiva, constituye un aspecto determinante para lograr el éxito empresarial, por lo que es necesario contar con instrumentos de medición puntuales, especialmente en firmas del sector servicios de entre las cuales destacan aquellas insertas en la actividad turística y de la cual el sector hotelero es pieza fundamental. La presente es una investigación exploratoria, descriptiva y no experimental, orientada a determinar la validez de contenido de un instrumento de medición de la ventaja competitiva del sector hotelero, en el contexto de Ciudad Juárez, desde dos modelos: Lawshe (1975) y Tristán (2008), a partir de un panel de expertos, quienes valoran el contenido y pertinencia de cada ítem; considerando que el CVI mínimo aceptable es de 0.582 y el valor obtenido es de 0.600, es posible concluir que el instrumento de medición evaluado es aceptable.
Using Hard Macros to Reduce FPGA Compilation Time (2010)

The FPGA compilation process (synthesis, map, placement, routing) is a time-consuming process that limits designer productivity. Compilation time can be reduced by using pre-compiled circuit blocks (hard macros). Hard macros consist of previously synthesized, mapped, placed and routed circuitry that can be relatively placed with short tool runtimes and that make it possible to reuse previous computational effort. Two experiments were performed to demonstrate feasibility that hard macros can reduce compilation time. These experiments demonstrated that an augmented Xilinx flow designed specifically to support hard macros can reduce overall compilation time by 3x. Though the process of incorporating hard macros in designs is currently manual and error-prone, it can be automated to create compilation flows with much lower compilation time.
Coplanar Lumped Elements and their Application in Filters on Ceramic and Gallium Arsenide Substrates (1989)

Propagation characteristics (dielectric contants, characteristic impedances and losses) of coplanar waveguides based on full wave spectral domain analysis are presented in this paper. Theoretical results of single coplanar waveguides fabricated on ceramic and gallium arsenide are compared with measurements to check on the computation and the validity of the theory. The computation is extended to multiconductor-coplanar waveguides whose results are also presented. Series interdigital capacitors in coplanar technique, as an application of coplanar multiconductor structures, are analysed. Finally, the application of lumped elements in a chebyschev band-pass filter is examined.
CAN-Ethernet Architectures for Real-Time Applications (2006)

Embedded systems have specific real-time requirements that led to the development of dedicated communication protocols. Such systems must face increasing communication needs and the evolution of switched Ethernet architecture. But moving from existing dedicated field-busses architectures to new Ethernet based architectures is not always feasible, due to industrial constraints. In this paper, we compare different solutions for integrating existing data busses (such as CAN, which is an important standard in automotive context) on a global architecture that respects increasing bandwidth requirements. In a first step, we study classical CAN/CAN bridging strategies. In a second step, we propose CAN/Ethernet bridging strategies that respect the real time behavior of CAN End System when communicating through an Ethernet network that can be shared by (non CAN) applications
Remote-Sensing Image Denoising With Multi-Sourced Information (2019)

In this paper, a new multi-source-information-based method for remote-sensing image denoising is proposed. Different from the conventional denoising algorithm, the proposed method employs the features of similar reference images from the different band, different sensors, or from multi-temporal images when denoising a target image. The noise-free reference images as a prior is introduced into the denoising object function. The prior's information about the reference image is explored in two aspects: dictionary learning and edge-feature prediction. For dictionary learning, we improve the basis training process by incremental singular value decomposition. For edge-feature prediction, we construct the relationship between gradients of the target image and the reference image by linear ridge regression. The new denoising object function employs both the sparsity of the coefficient and the edge similarity between the target image and the reference image. We also present the optimization scheme for the proposed denoising model. Some typical cases based on different feature relations between a target image and a reference image are comprehensively discussed. Reasonably utilizing the similarity between the target image and the reference image, the proposed algorithm smooths out more noise and conserves more detail at the same time. Better performance of the proposed method is confirmed when compared with other state-of-the-art reference-based denoising methods.
Epidemiology of functional shoulder instability: an online survey (2019)

Functional shoulder instability (FSI) is more common than expected amongst young adults and seems to develop during childhood mostly without specific reason.
Performance evaluation of ADN and BSN graduates (2015)

This study determined Directors' of Nursing (DNS) assessment of the preparation of new graduates\nfrom associate degree (ADN) and baccalaureate degree (BSN) nursing programs. A sample of 329\nDirectors from hospitals in the thirteen state,region represented in the Midwest Alliance of Nursing\nwere randomly selected. The questionnaire was developed based on Schwirian's Six Dimension Scale\nof Nursing, Performance (1978) . This scale was developed by Schwirian who established its reliability\nand validity. The scale yields a total scale mean score and six subscale mean scores on:\nTeaching/Collaboration, Planning/Evaluation, Leadership, Critical Care, Interpersonal\nRelationships/Communications, and Professional Development.\nPrinciples from Dillman's Mail and Telephone Surveys: A Total Design Method (1978) were used to\ndesign the questionnaire, conduct a pilot study and implement a survey that was conducted during\nDecember 1983 and January 1984. A return rate of 293 or 89 percent was achieved. Data analysis was\ncompleted on 249 questionnaires or 76 percent.\nA non-parametric Sign Test indicated baccalaureate graduates were rated higher than associate degree\non more items of the Six-D Scale.\nA Two-Way Analysis of Variance found that there was significant interaction between the initial "type"\nof RN education of the responding Directors and the ratings they gave ADN and BSN preparation on\nthe total scale score and five of six subscales. The nature of the interaction showed that Directors\nreceiving their initial RN education in ADN and diploma nursing programs rated ADN and BSN\ngraduate preparation closely. Directors who received their initial RN education in BSN programs rated\nBSN graduates preparation markedly higher and ADN graduates lower. It should be noted that BSN\ngraduates received higher assessments by Directors regardless of their preparation on all measures\nexcept when the Directors received their initial RN education in ADN programs. Those Directors rated\nthe preparation of ADN graduates higher than BSN graduates on the Critical Care subscale.\nA descriptive analysis, grouped by subscale, of the competencies and deficiencies of ADN and BSN\ngraduate preparation was presented. Accompanying tables with item analysis was presented to assist in\ncurricular planning and modification for nursing educators.
In Vivo Treg Suppression Assays (2011)

To fully examine the functionality of a regulatory T cell (Treg) population, one needs to assess their ability to suppress in a variety of in vivo models. We describe five in vivo models that examine the suppressive capacity of Tregs upon different target cell types. The advantages and disadvantages of each model including resources, time, and technical expertise required to execute each model are also described.