gebhart/patrepeval huggingface dataset:
Mixing Enhancement of Compressible Jets by Using Unsteady Microjets as Actuators (2002)

Lateralsteady/unsteadyinjectionofanarrayofmicrojets,whichareplacedalongthecircumferenceofthenozzle exit of a primary jet at equal intervals of azimuthal angle, was studied experimentally to clarify the characteristics of mixing and noise of compressible primary jets. Two modesof the microjets wereinvestigated: axisymmetric and antisymmetric injections. Fully expanded and underexpanded primary jets issued from a convergent nozzle are considered in thepresent study. Theunsteady microjets wereinjectedata Strouhal number Srof0.16, based on the nozzle exit diameter and the velocity at the nozzle exit, for two cases of total mass injection: 4 and 6% of primary jet mass e ow rate. Results of the mean e owe eld showed that the antisymmetric injection has a higher spreading ratethan the steady and unsteady axisymmetric injections in terms of centerlinevelocity decay. Thoseresults were cone rmed from linear stability analysis, which showed that antisymmetric modes for natural disturbances are more unstable in the downstream region than the corresponding axisymmetric modes. Moreover, reduction in the radiated noise was observed in steady axisymmetric injection. Thus, these results suggest that unsteady microjets have the potential for future use as a device for shear e ow control.
Renormalized molecular levels in a<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Sc</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mi mathvariant="normal">N</mml:mi><mml:mi>@</mml:mi><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">C</mml:mi></mml:mrow><mml:mrow><mml:mn>80</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>molecular electronic device (2001)

We address several general questions about quantum transport through molecular systems by an ab initio analysis of a scandium-nitrogen doped ${C}_{80}$ metallofullerene device. Charge transfer from the ${\mathrm{Sc}}_{3}\mathrm{N}$ is found to drastically change the current-voltage characteristics: the current through the ${\mathrm{Sc}}_{3}\mathrm{N}@{\mathrm{C}}_{80}$ device is double that through a bare ${C}_{80}$ device. We provide strong evidence that transport in such molecular devices is mediated by molecular electronic states which have been renormalized by the device environment, such as the electrodes and external bias ${V}_{b}.$ The renormalized molecular levels and main transmission features shift in energy corresponding to half the applied bias voltage. This is also consistent with our finding that the voltage drops by ${V}_{b}/2$ at each molecule/electrode contact.
The correlation of tumor associated antigen and hepatic fibrosis indexes in patients with chronic hepatitis B (2006)

Objective To study the correlation of tumor associated antigen and hepatic fibrosis indexes.Methods Fifty-one patients with chronic hepatitis B were selected,serum indexes(HA,LN,ⅣC,PⅢ,CEA,CA125,CA19-9,CA72-4,TB,DB,IB,ALT,AST)were measured in the above patients.Analysed the correlation between each index with Pearson correlation coefficients.Results The correlation were significant between serum indexes CEA,CA19-9,CA125 and HA,LN,ⅣC.The correlation between serum indexes CA19-9,CA125 and TB,DB,ALT were significant too.Conclusion Tumor associated antigens(CEA,CA125,CA19-9) are the early signs of alimentary system cancer.However,in the patients with chronic hepatitis B,they don't mean cancer sometimes when serum indexes(CEA,CA125,CA19-9)rise to abnormal level,their rise according to the process of fibrosis and inflammation in the liver.
Anti-cancer potential of flavonoids: recent trends and future perspectives (2013)

Cancer is a major public health concern in both developed and developing countries. Several plant-derived anti-cancer agents including taxol, vinblastine, vincristine, the campothecin derivatives, topotecan, irinotecan and etoposide are in clinical use all over the world. Other promising anti-cancer agents include flavopiridol, roscovitine, combretastatin A-4, betulinic acid and silvestrol. From this list one can well imagine the predominance of polyphenols, flavonoids and their synthetic analogs in the treatment of ovarian, breast, cervical, pancreatic and prostate cancer. Flavonoids present in human diet comprise many polyphenolic secondary metabolites with broad-spectrum pharmacological activities including their potential role as anti-cancer agents. A positive correlation between flavonoids-rich diet (from vegetables and fruits) and lower risk of colon, prostate and breast cancers lead to a question that whether flavonoids mediate the protective effects as chemopreventive agents or can interact with different genes and proteins to play role in chemotherapy. The current review emphasizes onto the therapeutic potential of flavonoids and their synthetic analogs as anti-cancer agents by providing new insights into the factors, regulation and molecular mechanisms along with their significant protein interactions.
Nanoporous Polymers Incorporating Sterically Confined <i>N</i>-Heterocyclic Carbenes for Simultaneous CO<sub>2</sub> Capture and Conversion at Ambient Pressure (2015)

Postcombustion CO2 capture and the conversion of captured CO2 into value added chemicals are integral part of today’s energy industry mainly due to their economic and environmental benefits arising from the direct utilization of CO2 as a sustainable source. Sterically confined N-heterocyclic carbenes (NHCs) have played a significant role in organocatalysis due to their air-stability, super basic nature, and strong ability to activate and convert CO2 gas. Here, we report a new class of nanoporous polymer incorporating sterically confined N-heterocyclic carbenes (NP-NHCs) that exhibit exceptional CO2 capture fixation efficiency of 97% at room temperature, which is the highest ever reported for carbene based materials measured in the solid state. The NP-NHC can also function as a highly active, selective, and recyclable heterogeneous nanoporous organocatalyst for the conversion of CO2 into cyclic carbonates at atmospheric pressure with excellent yields up to 98% along with 100% product selectivity through an atom economy reaction by using epoxides. Narrow pore size distribution of NP-NHC also allowed us to introduce a unique substrate selectivity based on size, just like enzymes, for the corresponding epoxides. This metal-free two in one approach for the CO2 gas fixation/release and conversion provides a new direction for the cost-effective, CO2 capture and conversion processes.
Adhesion of<i>Plasmodium falciparum</i>-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications (2009)

Severe malaria has a high mortality rate (15-20%) despite treatment with effective antimalarial drugs. Adjunctive therapies for severe malaria that target the underlying disease process are therefore urgently required. Adhesion of erythrocytes infected with Plasmodium falciparum to human cells has a key role in the pathogenesis of life-threatening malaria and could be targeted with antiadhesion therapy. Parasite adhesion interactions include binding to endothelial cells (cytoadherence), rosetting with uninfected erythrocytes and platelet-mediated clumping of infected erythrocytes. Recent research has started to define the molecular mechanisms of parasite adhesion, and antiadhesion therapies are being explored. However, many fundamental questions regarding the role of parasite adhesion in severe malaria remain unanswered. There is strong evidence that rosetting contributes to severe malaria in sub-Saharan Africa; however, the identity of other parasite adhesion phenotypes that are implicated in disease pathogenesis remains unclear. In addition, the possibility of geographic variation in adhesion phenotypes causing severe malaria, linked to differences in malaria transmission levels and host immunity, has been neglected. Further research is needed to realise the untapped potential of antiadhesion adjunctive therapies, which could revolutionize the treatment of severe malaria and reduce the high mortality rate of the disease.
Ensemble Classifier for Combining Stereo Matching Algorithms (2015)

Stereo matching, as many problems in computer vision, has been addressed by a multitude of algorithms, each with its own strengths and weaknesses. Instead of following the conventional approach and trying to tune or enhance one of the algorithms so that it dominates the competition, we resign to the idea that a truly optimal algorithm may not be discovered soon and take a different approach. We present a novel methodology for combining a large number of heterogeneous algorithms that is able to clearly surpass the accuracy of the most accurate algorithms in the set. At the core of our approach is the design of an ensemble classifier trained to decide whether a particular stereo matcher is correct on a certain pixel. In addition to features describing the pixel, our feature vector encodes the agreement and disagreement between the matcher under consideration and all other matchers. This formulation leads to high accuracy in disparity estimation on the KITTI stereo benchmark.
Naphthoxanthenyl, a New Stable Phenalenyl Type Radical Stabilized by Electronic Effects (2013)

Naphthoxanthenyl 1 is a new stable phenalenyl-type radical. Electrochemical studies indicate that 1 has two reversible redox processes that occur on comparatively short time scales. Crystals containing 1 can be grown by electrocrystallization, suggesting that they are conductive.
A location-based notification- and visualization-system indicating social activities (2009)

This paper examines the implementation of a notification- and visualization-system generally aiming to provide users with a comprehensive possibility to spontaneously get in touch and stay in contact with their friends and acquaintances. Essential part of the system is the mobile application, based on the Google Android platform, which can be used to keep track about the spatial positions of a user's contacts. One of the main aspects of the presented system is the automatic contact alert mechanism, which notifies users every time that one or more of their contacts are located nearby. In case a contact is in vicinity the application initiates a visual and/or acoustic signal on the mobile device. At any time users are able to easily take a glance at a geographical map displaying the surrounding area of their current position and all of their online contacts within this area. Moreover, users have the possibility to retrieve further information for each of their displayed contacts (if provided by the contact), such as their current activity or specific location metadata, e.g. the speed, direction and distance of a contact to the user's own location. Additionally, a user can explicitly look out for a specific contact, regardless of where the contact is located globally, as long as the contact is logged on to the system and shares his/her location information. Furthermore, the system supports the exchange of location- and event-messages, enabling users to easily share location data or set up appointments with their contacts. Another main feature of the prototype is the automatic location context determination, which provides users not just the raw location information on a map, but also the contextual meaning specified by the contact. That means users can see that a contact is e.g. at home or at work, when the user is indeed within the spatial range of his home or work location. The system can detect automatically if a user reaches one of his most common places and provide this information to contacts (allowance required).
Data mining with Clementine (1995)

Data mining is the extraction of useful information or knowledge from bodies of data. Data mining is also sometimes referred to as knowledge discovery in databases. Clementine is a comprehensive, integrated toolkit which provides active support for data mining in the form of neural network and rule induction learning techniques, passive support in the form of visualisation, statistical and browsing facilities, and peripheral support for data access and manipulation. Clementine's visual programming interface provides an environment which is easy to use for technological experts and non-experts alike, and provides a convenient organising framework for any data mining technique. Clementine makes machine learning accessible to non-experts. Clementine also goes beyond simple organisational advantages because it reduces the time taken to perform data mining experiments by one to two orders of magnitude. This means that experiments which would previously have been impractical in any realistic project are made possible by Clementine, effectively opening up new areas of exploration. The first commercial version of Clementine is currently on the market and is attracting a great deal of interest. Future versions will extend the machine learning facilities and provide many other new features. The utility of Clementine will continue to grow, and to provide new possibilities for data mining.
A Nonneutralizing Anti-HIV-1 Antibody Turns into a Neutralizing Antibody When Expressed on the Surface of HIV-1-Susceptible Cells: A New Way to Fight HIV (2004)

During HIV-1 infection or vaccination, HIV-1 envelope spikes elicit Ab responses. Neutralizing Abs block viral entry by recognizing epitopes on spikes critical for their interaction with receptor, coreceptors or fusion. In contrast, nonneutralizing Abs fail to do so because they recognize epitopes either buried or exposed but not critical for viral entry. Previously, we produced a high-affinity human mAb against the cluster II determinant of gp41. This Ab or its recombinant Fab and single-chain Fv have been repeatedly shown to bind to HIV-1 gp160 or gp41, but fail to block viral entry. We report that, surprisingly, expression of this nonneutralizing anti-HIV-1 gp41 single-chain Fv on the surface of human CD4 T cells markedly inhibits HIV-1 replication and cell-cell fusion. The inhibition targets the HIV-1 envelope at the level of viral entry, regardless of HIV-1 tropism. Although this bona fide nonneutralizing Ab does not neutralize HIV-1 entry when produced as a soluble protein, it acts as a neutralizing Ab when expressed on the cell surface. Expressing Abs on the surface of HIV-1-susceptible cells can be a new way to fight HIV-1.
Philippe Grosos, Comme un corps lourd dans une eau sombre. Essai sur le rayonnement paradoxal du mal.. Genève, Labor et Fides, 2011, 127 p. (2011)

On ne dira jamais assez, selon Ph. Grosos, combien vaine est la quete de l'origine du mal, de sa signification dans une conception « rationnelle » de l'existence de l'etre humain. Quelle raison convoquer pour un aussi irremissible « scandale » ? Le terme meme de scandale ne renvoie-t-il pas a un surgissement imprevu, une rupture dans l'ordre du monde, qui ne releve plus d'une interpretation totalisante de cet ordre et de ce monde – mais suppose une logique radicalement autre de pensee ? Une p...
Terminal and new bridging coordination of methylguanidine, arginine, and canavanine to platinum(II). The first crystallographic study of bonding between a transition metal and a guanidine ligand (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTerminal and new bridging coordination of methylguanidine, arginine, and canavanine to platinum(II). The first crystallographic study of bonding between a transition metal and a guanidine ligandEva Marie A. Ratilla, Brian K. Scott, Michael S. Moxness, and Nenad M. KosticCite this: Inorg. Chem. 1990, 29, 5, 918–926Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ic00330a006https://doi.org/10.1021/ic00330a006research-articleACS PublicationsRequest reuse permissionsArticle Views601Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A perspective on the bright future of metal halide perovskites for X-ray detection (2019)

Metal halide perovskites (MHPs) changed the world of solution processed semiconductors, previously dominated by organic semiconductors, toward predominantly inorganic materials with a relatively high electron/hole mobility. A series of devices benefit from their optoelectronic properties, including X-ray detectors. After the introduction of MHP X-ray detectors in 2013, they have achieved significant improvements in the form of single crystals, polycrystalline materials, and pixelated imaging devices. In addition, MHPs in the form of colloidal nanocrystals act as excellent scintillators. We see the bright future of MHPs in energy resolved X-ray detection, either achieved in the single counting mode, or in nanocrystal multilayer stacked devices, acting as a combination of selective X-ray filters and scintillators.
Research Progress of Unsaturated Soil Seepage (2015)

Unsaturated seepage is not only widely used in geotechnical engineering, but also a hot problem. And accurate evaluation seepage has an important role in improving the accuracy of geotechnical calculation. The paper reviews the characteristics retrospectively according to a large amount of literature, from the unsaturated seepage numerical solution, saturation, deformation and occluded bubbles four aspects, then points out the existing problems at present in our country, and at last discusses the future prospect.
Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents (2003)

The sulfonamides constitute an important class of drugs, with several types of pharmacological agents possessing antibacterial, anticarbonic anhydrase, diuretic, hypoglycemic, and antithyroid activity among others. A large number of structurally novel sulfonamide derivatives have ultimately been reported to show substantial protease inhibitory properties. Of particular interest are some metalloprotease inhibitors belonging to this class, which by inhibiting several matrix metalloproteases (MMPs) show interesting antitumor properties. Some of these compounds are currently being evaluated in clinical trials. The large number of sulfonamide MMP inhibitors ultimately reported also lead to the design of effective tumor necrosis factor-alpha converting enzyme (TACE) inhibitors, potentially useful in the treatment of inflammatory states of various types. Since both MMPs and TACE contribute synergistically to the pathophysiology of many diseases, such as arthritis, bacterial meningitis, tumor invasion; the dual inhibition of these enzymes emerged as an interesting target for the drug design of anticancer/antiinflammatory drugs, and many such sulfonamide derivatives were recently reported. Human neutrophyl elastase (HNE) inhibitors of the sulfonamide type may also be useful in the treatment of inflammatory conditions, such as emphysema, cystic fibrosis, chronic bronchitis, ischemia reperfusion injury, and acute respiratory distress syndrome. Inhibition of some cysteine proteases, such as several caspase and cathepsin isozymes, may lead to the development of pharmacological agents effective for the management of several diseases, such as rheumatoid arthritis, inflammatory bowel disease, brain damage, and stroke. Another research line that progressed much in the last time regards different sulfonamides with remarkable antiviral activity. Some clinically used HIV protease inhibitors (such as amprenavir) possess sulfonamide moieties in their molecules, which are critical for the potency of these drugs, as shown by means of X-ray crystallography, whereas a very large number of other derivatives are constantly being synthesized and evaluated in order to obtain compounds with lower toxicity or augmented activity against viruses resistant to the such first generation drugs. Other viral proteases, such as those isolated from several types of herpes viruses may be inhibited by sulfonamide derivatives, leading thus to more effective classes of antiviral drugs.
Monocular 3D Reconstruction of Locally Textured Surfaces (2011)

Most recent approaches to monocular nonrigid 3D shape recovery rely on exploiting point correspondences and work best when the whole surface is well textured. The alternative is to rely on either contours or shading information, which has only been demonstrated in very restrictive settings. Here, we propose a novel approach to monocular deformable shape recovery that can operate under complex lighting and handle partially textured surfaces. At the heart of our algorithm are a learned mapping from intensity patterns to the shape of local surface patches and a principled approach to piecing together the resulting local shape estimates. We validate our approach quantitatively and qualitatively using both synthetic and real data.
The V delta 1 T cell receptor repertoire in human small intestine and colon. (1994)

V delta 1 bearing T cells comprise the major population of gamma/delta T cells in the human intestinal tract. To gain insight into mechanisms involved in the generation of these cells and the diversity of their repertoire, we have characterized the junctional sequences of V delta 1 T cell receptor transcripts in the human small intestine and colon. Mucosal biopsies obtained from defined regions along the length of the small intestine or colon contained a high frequency of either one or a few identical in frame V delta 1 sequences. Less abundant sequences were also detected repeatedly throughout the length of small intestine or colon. Moreover, the intestinal V delta 1 repertoire in the small intestine and colon appeared compartmentalized and showed no overlap with the V delta 1 repertoire in peripheral blood. Dominant V delta 1 transcripts in each subject differed between the small intestine and colon, and the dominant transcripts within these sites differed among individuals. Analysis of small intestinal transcripts obtained at a 1-yr interval revealed that the V delta 1 repertoire was stable over time. The fact that the majority of V delta 1 transcripts, both dominant and rare, are distributed throughout a several meter length of the adult intestinal tract and are stable over time suggests they are not generated by an ongoing process of in situ VDJ gene rearrangement. Our results favor a model in which the repertoire of V delta 1 T cells in the intestinal tract is shaped by positive selection in response to a limited array of ligands before the migration of V delta 1 cells throughout the small intestine or colon.