gebhart/patrepeval huggingface dataset:
Identification of a Novel Benzimidazole That Inhibits Bacterial Biofilm Formation in a Broad-Spectrum Manner (2011)

Bacterial biofilm formation causes significant industrial economic loss and high morbidity and mortality in medical settings. Biofilms are defined as multicellular communities of bacteria encased in a matrix of protective extracellular polymers. Because biofilms have a high tolerance for treatment with antimicrobials, protect bacteria from immune defense, and resist clearance with standard sanitation protocols, it is critical to develop new approaches to prevent biofilm formation. Here, a novel benzimidazole molecule, named antibiofilm compound 1 (ABC-1), identified in a small-molecule screen, was found to prevent bacterial biofilm formation in multiple Gram-negative and Gram-positive bacterial pathogens, including Pseudomonas aeruginosa and Staphylococcus aureus, on a variety of different surface types. Importantly, ABC-1 itself does not inhibit the growth of bacteria, and it is effective at nanomolar concentrations. Also, coating a polystyrene surface with ABC-1 reduces biofilm formation. These data suggest ABC-1 is a new chemical scaffold for the development of antibiofilm compounds.
Esdcat: a new cad software package for full-chip esd protection circuit design verification (2005)

Electrostatic Discharge (ESD) induced failure is one of the most devastating reliability problems to ICs (integrated circuits). On-chip ESD protection is therefore required for all IC chips to prevent ESD damages from happening. New CAD (computer-aided design) tools are essential to ESD protection design prediction and verification at full chip level. This work focuses on developing the first intelligent CAD tool package, entitled ESDCat, for full-chip ESD design verification at both layout level and schematic level. At the layout level, the ESDCat package consists of two modules: ESDExtractor, and ESDInspector. ESDExtractor is a new arbitrary ESD protection device extraction CAD tool that allows extraction of all possible ESD protection devices of arbitrary types, intentional or parasitic, from IC layout files. The main function of the ESDInspector is to remove non-critical ESD devices extracted and perform intelligent physical design checking at layout level based upon a novel smart parametric checking mechanism. At the schematic level, ESD device modeling and circuit simulation using HSPICE is discussed. The future work is to develop a mix-mode circuit simulator, called ESDSimulator. Finally, ESDZapper is developed to simulate the complex ESD measurements, called ESD zapping tests.
A Novel Distributed Optical Fibre Sensing System Enabling Location Of Disturbances In A Sagnac Loop Interferometer. (1988)

The paper describes a novel, distributed fibre optic sensor capable of detecting and locating a disturbance on a continuous length of fibre. The sensor is based on a Sagnac loop interferometer. Any disturbance that causes a phase shift in the light propagating within the fibre loop, such as a change in the mechanical strain or temperature of the fibre, can be located. The basic principle of operation is described and preliminary results, obtained from a feasibility experiment, are given.
PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using <sup>18</sup>F-Radiolabeled Camelid Single-Domain Antibody Fragments (2015)

Anti-MMR 3.49 was denoted as the lead cross-reactive MMR-targeting sdAb. (18)F radiosynthesis was optimized, providing an optimal probe for PET imaging of the tumor-promoting macrophage subpopulation in the tumor stroma.
Generic Approach to Business Document Modelling (2006)

The diploma thesis at hand proposes a graphical modelling methodology for business documents. This methodology is based on the Core Component Technical Speci�cation (CCTS) and located on a high semantic level, independent of the syntax-representation of a particular standard. Business documents are composed of semantic building blocks. Generic templates of building blocks, called Core Components (CCs), make up templates of business documents. Speci �c variants of CCs are called Business Information Entities (BIEs) and make up variants of these business documents. The presented mechanisms for variant handling and extensibility allow a high degree of reusability of these building blocks. They can be reused by multiple business documents and dfferent business document standards. The diploma thesis at hand also examines application components, which support the business document modeller and hide the complexity and constraints of business document modelling. The combination of a simple but comprehensive modelling methodology and practical application components allows even non-experts to participate in the speci�cation of business data. The generic modelling methodology that is implemented in form of a modelling environment accompanying this diploma thesis, allows to model business data for different business document standards such as UBL and RosettaNet. The diploma thesis elaborates how this can be realised and the inherent limitations. Furthermore, the adoption of the CCTS template-variant approach allows to identify common parts of different business documents. This simpli�es mappings between different standards because the semantic of every syntaxrepresentation of a business document is speci�ed by the generic template. It does not solve the general problem of data integration but is a step towards the support for different standards by a common modelling methodology.
Synchronous marker for measuring phase in the presence of noise (1977)

A circuit has been constructed to mark the phase of a sinusoidal signal even when it is obscured by noise. The time jitter of the marker signal due to the noise can be reduced as much as desired in trade for slowed response time of the circuit. A theoretical description of the performance of the circuit and an error analysis are presented. Results of tests on the circuit agree approximately with the theoretical description.
Interband cascade lasers with CW wallplug efficiency higher than 40% at low temperatures (2016)

We report cw wallplug efficiencies (WPEs) for mid-infrared interband cascade lasers (ICLs) that are comparable to those of state-of-the-art quantum cascade lasers at temperatures ranging from the cryogenic regime to room temperature. The continuous wave (cw) WPE for 10-stage broad-area devices remains above 40% for temperatures up to 125 K, and is still <30% at <i>T</i> = 175 K. At 80 K the threshold current density for a 2-mm-long cavity is only 11 A/cm<sup>2</sup>, and slope efficiencies are < 2.2 W/A at all temperatures ≤ 200 K. A 32-μm-wide × 3-mm-long ridge with 7 active stages and high-reflection and anti-reflection coatings on the two facets displays a cw WPE of 24% at <i>T</i> = 200 K and 12% at <i>T</i> = 300 K. The cw WPE of another narrow-ridge ICL was 18% at room temperature.
Urine Pretreatment Configuration and Test Results for Space Applications (1998)

Pretreatment of urine using Oxone and sulfuric acid is baselined in the International Space Station (ISS) waste water reclamation system to control odors, fix urea and control microbial growth. In addition, pretreatment is recommended for long term flight use of urine collection and two phase separation to reduce or eliminate fouling of the associated hardware and plumbing with urine precipitates. This is important for ISS application because the amount of maintenance time for cleaning and repairing hardware must be minimized. This paper describes the development of a chemical pretreatment system based on solid tablet shapes which are positioned in the urine collection hose and are dissolved by the intrained urine at the proper ratio of pretreatment to urine. Building upon the prior success of the developed and tested solid Oxone tablet a trade study was completed to confirm if a similar approach, or alternative, would be appropriate for the sulfuric acid injection method. In addition, a recommended handling and packaging approach of the solid tablets for long term, safe and convenient use on ISS was addressed. Consequently, the solid tablet concept with suitable packaging was identified as the Urine Pretreat / Prefilter Assembly (UPPA). Testing of the UPPA configuration confirmed the disolution rates and ratios required by ISS were achieved. This testing included laboratory controlled methods as well as a 'real world' test evaluation that occurred during the 150 day Stage 10 Water Recovery Test (WRT) conducted at NASA Marshall Space Flight Center (MSFC).
A security and trust framework for virtualized networks and software-defined networking (2015)

With the great success of the second-generation wireless telephone technology and the third-generation mobile telecommunications technology, and the fast development of the fourth-generation mobile telecommunications technology, the phase of fifth-generation mobile networks or fifth-generation wireless systems 5G is coming. In this article, we indicate the open research issues of 5G security and trust in the context of virtualized networking and software-defined networking. We further propose a framework of security and trust focusing on solving 5G network security issues. The proposed framework applies adaptive trust evaluation and management technologies and sustainable trusted computing technologies to ensure computing platform trust and achieve software-defined network security. It adopts cloud computing to securely deploy various trustworthy security services over the virtualized networks. We analyze that the framework can support and satisfy all security requirements specified in standardization. We also suggest future research work according to the proposed framework and discuss the advantages of our framework in terms of practical deployment. Copyright © 2015 John Wiley & Sons, Ltd.
Lot-to-lot consistency of a tetravalent dengue vaccine in healthy adults in Australia: A randomised study (2015)

Phase III lots can be produced in a consistent manner with predictable immune response and acceptable safety profile similar to previously characterised phase II lots. The phase III lots may be considered as not clinically different as statistical equivalence was shown for serotypes 1, 3 and 4 across the phase III lots. For serotype 2, although equivalence was not shown between two lots, the GMTs observed in the phase III lots were consistently higher than those for the phase II lot. As such, in our view, biological equivalence for all serotypes was demonstrated.
Dihydroergotamine (DHE) – Then and Now: A Narrative Review (2019)

There is renewed appreciation for DHE and the need for non-oral, non-injected delivery is now being addressed.
Nondestructive testing by digital shearography using a Savart plate (2009)

Shearography is a growing optical technique in the field of non-destructive testing (NDT)[1],[2]. Hololab developed an out of plane, in line and almost common path interferometer based on polarization states separation using a coated prism for digital phase-shifting shearography[3]. This setup is efficient but does not allow varying the shearing direction that is an important parameter for defects detection[1]and quantification[2]. To overcome this disadvantage, the coated prism is substituted by a Savart plate device that allows scanning several shearing directions by rotating the device around the light propagation axis. The behaviour of the Savart plate as a shearing device is experimentally analyzed to optimize its integration within the interferometer. Recorded phasemaps in NDT for different shearing directions are presented.
Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge <i>Leiodermatium</i> sp. (2011)

Aus der Tiefe: Leiodermatolid, ein Makrolid mit einzigartiger Struktur, das aus dem Tiefseeschwamm Leiodermatium sp. isoliert wurde, zeigt proliferationshemmende Aktivität gegen mehrere Krebszelllinien sowie drastische Effekte auf die Spindelbildung in mitotischen Zellen. Das ungewöhnliche Polyketidgerüst und die stereochemische Konfiguration des Moleküls wurden durch eine Kombination aus experimentellen und computergestützten NMR-Methoden ermittelt.
<i>TBC1D24</i>Mutation Causes Autosomal-Dominant Nonsyndromic Hearing Loss (2014)

Hereditary hearing loss is extremely heterogeneous. Over 70 genes have been identified to date, and with the advent of massively parallel sequencing, the pace of novel gene discovery has accelerated. In a family segregating progressive autosomal-dominant nonsyndromic hearing loss (NSHL), we used OtoSCOPE® to exclude mutations in known deafness genes and then performed segregation mapping and whole-exome sequencing to identify a unique variant, p.Ser178Leu, in TBC1D24 that segregates with the hearing loss phenotype. TBC1D24 encodes a GTPase-activating protein expressed in the cochlea. Ser178 is highly conserved across vertebrates and its change is predicted to be damaging. Other variants in TBC1D24 have been associated with a panoply of clinical symptoms including autosomal recessive NSHL, syndromic hearing impairment associated with onychodystrophy, osteodystrophy, mental retardation, and seizures (DOORS syndrome), and a wide range of epileptic disorders.
<i>piggyBac</i> internal sequences are necessary for efficient transformation of target genomes (2005)

A previously reported piggyBac minimal sequence cartridge, which is capable of efficient transposition in embryo interplasmid transposition assays, failed to produce transformants at a significant frequency in Drosophila melanogaster compared with full-length or less extensive internal deletion constructs. We have re-examined the importance of these internal domain (ID) sequences for germline transformation using a PCR strategy that effectively adds increasing lengths of ID sequences to each terminus. A series of these piggyBac ID synthetic deletion plasmids containing the 3xP3-ECFP marker gene are compared for germline transformation of D. melanogaster. Our analyses identify a minimal sequence configuration that is sufficient for movement of piggyBac vectored sequences from plasmids into the insect genome. Southern hybridizations confirm the presence of the piggyBac transposon sequences, and insertion site analyses confirm these integrations target TTAA sites. The results verify that ID sequences adjacent to the 5' and 3' terminal repeat domains are crucial for effective germline transformation with piggyBac even though they are not required for excision or interplasmid transposition. Using this information we reconstructed an inverted repeat cartridge, ITR1.1k, and a minimal piggyBac transposon vector, pXL-BacII-ECFP, each of which contains these identified ID sequences in addition to the terminal repeat configuration previously described as essential for mobility. We confirm in independent experiments that these new minimal constructs yield transformation frequencies similar to the control piggyBac vector. Sequencing analyses of our constructs verify the position and the source of a point mutation within the 3' internal repeat sequence of our vectors that has no apparent effect on transformation efficiency.
Proposal for detection of magnetic fields through magnetostrictive perturbation of optical fibers (1980)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Amnon Yariv and Harry V. Winsor, "Proposal for detection of magnetic fields through magnetostrictive perturbation of optical fibers," Opt. Lett. 5, 87-89 (1980) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Novel associated hydrogels for nucleus pulposus replacement (2003)

Hydrogels of poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) blends may provide a material suitable for replacement of the nucleus pulposus of the intervertebral disc. This research examined the stability of these hydrogels under simulated physiological conditions. Polymer dissolution and stability were characterized over 120 days immersion, chemical surface analysis over 56 days immersion, and tensile mechanical behavior over 56 days immersion. Rubber elasticity theory was used by combining mechanical results with swelling data to calculate network characteristics such as the molecular weight between physical crosslinks and density of crosslinks. Properties were examined as a function of PVA/PVP composition as well as PVA molecular weight and PVP molecular weight. Results indicated that PVA/PVP blends prepared with moderate amounts of PVP (0.5-5%) resulted in a polymer network stabilized through interchain hydrogen bonding between hydroxyl groups on PVA chains and carbonyl groups on PVP chains. Most notably, a significant decrease in percentage of polymer mass loss was seen for blends prepared with 143K molecular weight PVA. Surface chemical analysis revealed that PVP unincorporated in the network structure suffered significant dissolution out of the polymer network and into solution. The molecular weight of PVA and PVP were shown to have a significant influence on the blends' network properties. Gels prepared with lower molecular weight PVA resulted in a more stable blend containing a higher density of crosslinks. However, blends prepared with a higher molecular weight PVA showed superior polymer network stability in dissolution studies. The blend that had the best combination of network stability under physiological conditions and a relatively tight, stable, and crosslinked network was prepared with 99% PVA (143K) and 1% PVP (40K). This material is proposed as an implant material for replacement of the degenerated nucleus pulposus.
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma (2009)

In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.
Liposome-based flow-injection immunoassay system (1988)

The development of many biochemical assays is dependent upon the specific interaction of an antigen with its antibody. This interaction is usually monitored using secondary labels with the most popular immunoassays employing fluorescent or
A Foxtail mosaic virus Vector for Virus-Induced Gene Silencing in Maize (2016)

Plant viruses have been widely used as vectors for foreign gene expression and virus-induced gene silencing (VIGS). A limited number of viruses have been developed into viral vectors for the purposes of gene expression or VIGS in monocotyledonous plants, and among these, the tripartite viruses Brome mosaic virus and Cucumber mosaic virus have been shown to induce VIGS in maize (Zea mays). We describe here a new DNA-based VIGS system derived from Foxtail mosaic virus (FoMV), a monopartite virus that is able to establish systemic infection and silencing of endogenous maize genes homologous to gene fragments inserted into the FoMV genome. To demonstrate VIGS applications of this FoMV vector system, four genes, phytoene desaturase (functions in carotenoid biosynthesis), lesion mimic22 (encodes a key enzyme of the porphyrin pathway), iojap (functions in plastid development), and brown midrib3 (caffeic acid O-methyltransferase), were silenced and characterized in the sweet corn line Golden × Bantam. Furthermore, we demonstrate that the FoMV infectious clone establishes systemic infection in maize inbred lines, sorghum (Sorghum bicolor), and green foxtail (Setaria viridis), indicating the potential wide applications of this viral vector system for functional genomics studies in maize and other monocots.
Cancer-related overexpression of the peripheral-type benzodiazepine receptor and cytostatic anticancer effects of Ginkgo biloba extract (EGb 761). (2006)

The peripheral-type benzodiazepine receptor (PBR) is an 18-kDa high affinity drug- and cholesterol-binding protein that is involved in various cell functions, including cell proliferation and apoptosis. PBR was shown to be overexpressed in certain types of malignant human tumors and cancer cell lines, correlating with enhanced tumorigenicity and cell proliferation rates. The present study was conducted in order to further define the role of PBR in cancer and to extend our recent findings regarding the possible anticancer effects of the standardized Ginkgo biloba extract EGb 761. Treatment with EGb 761 decreased PBR mRNA levels and inhibited the proliferation of breast, glioma and hepatocarcinoma cell lines, further corroborating our previous contention that its mechanism of action is through the modification of PBR expression. In vivo treatment with Ginkgo biloba extract led to dose-dependent decreases in xenograft growth of both MDA-MB-231 breast cancer and U-87 glioma cell lines in nude mice, although the effects were not maintained after 50 days of treatment in the latter. The results obtained in MDA-MB-231 xenografts indicated pronounced inhibition of tumor growth, verified by MRI imaging. These results were obtained using a modified experimental protocol where the animals were treated with the extract before cell inoculation. Although an exact role for PBR in relation to the initiation and progression of various types of cancer remains to be defined, our results indicate that PBR overexpression in certain cancer cells is related to an aggressive phenotype. Since EGb 761 treatment opposes this aggressive phenotype by decreasing PBR overexpression, it could be useful in preventing or treating cancer invasiveness and metastasis.
Synthesis and Structure−Activity Relationships of Chiral Allosteric Modifiers of Hemoglobin (2000)

A series of allosteric effectors of hemoglobin, 2-(aryloxy)-2-alkanoic acids, was prepared to investigate the effect of the stereocenter on allosteric activity. The chiral analogues were based on the lead compound, RSR13 (3b), with different alkyl/alkanoic and cycloalkyl/cycloalkanoic groups positioned at the acidic chiral center. Of the 23 racemic molecules synthesized, 5 were selected for resolution based on structure-activity relationships. One chiral analogue, (-)-(1R,2R)-1-[4-[[(3, 5-dimethylanilino)carbonyl]methyl]phenoxy]-2-methylcyclopentane carbox ylic acid (11), exhibited greater in vitro activity in hemoglobin solutions than its antipode, racemate, and RSR13. Compound (-)-(1R, 2R)-11 was equipotent with RSR13 in whole blood, is a candidate for in vivo animal studies, and if efficacious and safe has a potential for use in humans. In general, it was found that chirality affects allosteric effector activity with measurable differences observed between enantiomers and the racemates.
Segmented Planar Imaging Detector for EO Reconnaissance (2013)

We propose an electro-optical (EO) imaging sensor concept that provides a low-mass, low-volume alternative to conventional system designs by using arrays of photonic integrated circuits. We will discuss design concepts and present basic experimental results.
Frequency-tunable nano-oscillator based on Ovonic Threshold Switch (OTS) (2020)

Nano-oscillator devices are gaining more and more attention as a prerequisite for developing novel energy-efficient computing systems based on coupled oscillators. Here, we introduce a highly scalable, frequency-tunable nano-oscillator consisting of one Ovonic threshold switch (OTS) and a field-effect transistor (FET). It is presented that the proposed device shows an oscillating behavior with a natural frequency (f_{nat}) adjustable from 0.5 to 2 MHz depending on the gate voltage applied to the FET. In addition, under a small periodic input, it is observed that the oscillating frequency (f_{osc}) of the device is locked to the frequency (f_{in}) of the input when f_{in} ~ f_{nat}, demonstrating the so-called synchronization phenomenon. It also shows the phase lock of the combined oscillator network using circuit simulation, where the phase relation between the oscillators can be controlled by the coupling strength. These results imply that the proposed device is promising for applications in oscillator-based computing systems.