gebhart/patrepeval huggingface dataset:
Plant Proanthocyanidins Bind to and Neutralize Bacterial Lipopolysaccharides (2008)

Proanthocyanidins (PACs) are naturally occurring polymers derived from higher plants and they have recently been associated with several potential positive health benefits such as antibacterial, chemotherapeutic, and anti-atherosclerotic activities. Here we report on the binding of PACs from cranberries, tea, and grapes to lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria. LPS is the cause of several human illnesses, including sepsis and toxic shock syndrome. We show that in the case of cranberries, the majority of the LPS-binding activity is contained within a PAC fraction composed of polymers with an average degree of polymerization of 21. This PAC fraction modestly inhibits the binding of LPS to the surface of mammalian cells expressing the full complement of LPS receptors while it significantly abrogates the cellular internalization of LPS. Our results demonstrate PACs to be a new class of LPS-binding compound with potential utility in the removal of LPS from potable water sources and pharmaceutical preparations.
Deep Learning Based Integrated Classification and Image Retrieval System for Early Skin Cancer Detection (2019)

Skin cancer is one of the most frequent cancers among human beings. Diagnosing an unknown skin lesion is the first step to determine appropriate treatment. This paper proposes an integrated classification and retrieval based Decision Support System (DSS) for skin cancer detection with an `easy to use' user interface by applying fusion and ensemble techniques in deep feature spaces. The descriptiveness and discriminative power of features extracted from dermoscopic images are critical to achieve good classification and retrieval performances. In this work, several deep features are extracted based on using transfer learning in several pre-trained Convolutional Neural Networks (CNNs) and Logistic Regression and Support Vector Machine (SVM) models are built as ensembles of classifiers on top of these feature vectors. Furthermore, the content-based image retrieval (CBIR) technique uses the same deep features by fusing those in different feature combinations using a canonical correlation analysis. Based on image-based visual queries submitted by dermatologists, this system would respond by displaying relevant images of pigmented skin lesions of past cases as well as classifying the image category as different types of skin cancer. The system has been trained on a dermoscopic image dataset consists of 1300 images of ten different classes. The best classification (85%) and retrieval accuracies are achieved in a test data set when feature fusion and ensemble techniques are used in all available deep feature spaces. This integrated system would reduce the visual observation error of human operators and enhance clinical decision support for early screening of kin cancers.
Multi-stage, high-gradient, cyclotron resonance proton accelerator concept (2001)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. L. Hirshfield, Changbiao Wang, Robert Symons; Multi-stage, high-gradient, cyclotron resonance proton accelerator concept. AIP Conf. Proc. 31 May 2001; 569 (1): 833–843. https://doi.org/10.1063/1.1384408 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Nuclear Detection of Cellular Retinoic Acid Binding Proteins I and II with New Antibodies (1998)

Apart from the retinoic acid nuclear receptor family, there are two low molecular weight (15 kD) cellular retinoic acid binding proteins, named CRABPI and II. Mouse monoclonal and rabbit polyclonal antibodies were raised against these proteins by using as antigens either synthetic peptides corresponding to amino acid sequences unique to CRABPI or CRABPII, or purified CRABP proteins expressed in E. coli. Antibodies specific for mouse and/or human CRABPI and CRABPII were obtained and characterized by immunocytochemistry and immunoblotting. They allowed the detection not only of CRABPI but also of CRABPII in both nuclear and cytosolic extracts from transfected COS-1 cells, mouse embryos, and various cell lines.
Checkerboard seed-blanket thorium fuel core concepts for heavy water moderated reactors (2013)

New reactor concepts to implement thorium-based fuel cycles have been explored to achieve maximum resource utilization. Pressure tube heavy water reactors (PT-HWR) are highly advantageous for implementing the use of thorium-based fuels because of their high neutron economy and on-line re-fuelling capability. The use of heterogeneous seed-blanket core concepts in a PT-HWR where higher-fissile-content seed fuel bundles are physically separate from lower-fissile-content blanket bundles allows more flexibility and control in fuel management to maximize the fissile utilization and conversion of fertile fuel. The lattice concept chosen was a 35-element bundle made with a homogeneous mixture of reactor grade Pu (about 67 wt% fissile) and Th, and with a central zirconia rod to help reduce coolant void reactivity. Several checkerboard heterogeneous seed-blanket core concepts with plutonium-thorium-based fuels in a 700-MWe-class PT-HWR were analyzed, using a once-through thorium (OTT) cycle. Different combinations of seed and blanket fuel were tested to determine the impact on core-average burnup, fissile utilization, power distributions, and other performance parameters. It was found that various checkerboard core concepts can achieve a fissile utilization that is up to 26% higher than that achieved in a PT-HWR using more conventional natural uranium fuel bundles. Up to 60% of the Pu more » is consumed; up to 43% of the energy is produced from thorium, and up to 303 kg/year of Pa-233/U-233/U-235 are produced. Checkerboard cores with about 50% of low-power blanket bundles may require power de-rating (65% to 74%) to avoid exceeding maximum limits for channel and bundle powers and linear element ratings. (authors) « less
A tunable cohesive granular material (2016)

By mixing glass beads with a curable polymer we create a well-defined cohesive granular medium, held together by solidified, and hence elastic, capillary bridges. This material has a geometry similar to a wet packing of beads, but with an additional control over the elasticity of the bonds holding the particles together. We show that its mechanical response can be varied over several orders of magnitude by adjusting the size and stiffness of the bridges, and the size of the particles. We also investigate its mechanism of failure under unconfined uniaxial compression in combination with in situ x-ray microtomography. We show that a broad linear-elastic regime ends at a limiting strain of about 8%, whatever the stiffness of the agglomerate, which corresponds to the beginning of shear failure. The possibility to finely tune the strength, size and shape of this simple material makes it an ideal model system for investigations on, for example, fracturing of porous rocks, seismology, or root growth in cohesive porous media.
Flexible MM-wave dielectric waveguides (1985)

Flexible dielectric waveguides have been demonstrated at 10 GHz and 94 GHz by filling hollow, low-dielectric-constant polymer tubes with low-loss, high-dielectric-constant powders. Flexible guides with losses as low as 0.12 dB/cm were demonstrated at 94 GHz. These guides also exhibited negligible bending loss for radii of curvature greater than 4 cm.
Parametric Study of Solid Amine Sorbents for the Capture of Carbon Dioxide<sup>†</sup> (2009)

Solid amine sorbents were prepared using mixtures of linear and branched primary, secondary, and tertiary amines. These amines were immobilized within polystyrene (PS)-, silicon dioxide (SiO2)-, or polymethylmethacrylate (PMMA)-based substrates at various weight ratios. Testing was conducted in various reactor systems, where the reactive water required for the capture of carbon dioxide (CO2) was tracked during the adsorption/desorption cycles by mass spectrometer gas analysis. The water management for these sorbents was quantified and used to assess the technical feasibility of the operating conditions for the capture of CO2 from simulated flue gas streams. In addition, the heats of reaction and performance capture loading capacities of these sorbents were also determined by differential scanning calorimetry (DSC) and thermogravimetric analyses (TGAs), respectively, in both dry and humidified CO2 gas streams. The regenerable solid amine sorbents investigated in this study exhibit acceptable CO2-capture loading capacities of 2.5−3.5 mol of CO2/kg of sorbent by TGA and a laboratory-scale fixed-bed reactor. These sorbents were stable over the adsorption/desorption temperature range of 25−105 °C for 10 cyclic tests. According to the DSC analysis, the heat of reaction generated by these sorbents was in the range of 400−600 Btu/lb. CO2, which will require a reactor with heat management capabilities.
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis (2003)

The cell envelope of pathogenic mycobacteria is highly distinctive in that it contains a large number of structurally related very long multiple methyl-branched fatty acids. These complex molecules are thought to play important roles in cell envelope organization and virulence. The genetic and enzymic characterization of the polyketide synthase Mas, which is responsible for the synthesis of one such family of fatty acids (the mycocerosic acids), paved the way towards the identification of other enzymes involved in the synthesis of methyl-branched fatty acids in M. tuberculosis. In an effort to elucidate the origin of these complex fatty acids and their possible involvement in pathogenesis, the two mas-like polyketide genes pks5 and pks7 were disrupted in M. tuberculosis and the effects of their inactivation on fatty acid composition and virulence were analysed. While the disruption of pks7 resulted in a mutant deficient in the production of phthiocerol dimycocerosates, the cell envelope composition of the pks5 mutant was found to be identical to that of the wild-type parental strain M. tuberculosis H37Rv. Interestingly, both the pks5 and pks7 mutants displayed severe growth defects in mice.
Correlated load-address predictors (2003)

As microprocessors become faster, the relative performance cost of memory accesses increases. Bigger and faster caches significantly reduce the absolute load-to-use time delay. However, increase in processor operational frequencies impairs the relative load-to-use latency, measured in processor cycles (e.g. from two cycles on the Pentium processor to three cycles of more in current designs). Load-address prediction techniques were introduced to partially cut the load-to-use latency. This paper focuses on advanced address-prediction schemes to further shorten program execution time. Existing address prediction schemes are capable of predicting simple address patterns, consisting mainly of constant addresses or stride-based addresses. This paper explores the characteristics of the remaining loads and suggests new enhanced techniques to improve prediction effectiveness: Context-based prediction to tackle part of the remaining, difficult-to-predict, load instructions. New prediction algorithms to take advantage of global correlation among different static loads. New confidence mechanisms to increase the correct prediction rate and to eliminate costly mispredictions. Mechanisms to prevent long or random address sequences from polluting the predictor data structures while providing some hysteresis behavior to the predictions. Such an enhanced address predictor accurately predicts 67% of all loads, while keeping the misprediction rate close to 1% We further prove that the proposed predictor works reasonably well in a deep pipelined architecture where the predict-to-update delay may significantly impair both prediction rate and accuracy.
Zinc Blende Magnesium Sulfide in Rechargeable Magnesium-Sulfur Batteries (2018)

Magnesium-sulfur batteries are one of the most promising next-generation battery systems due to their high energy density, low cost, and high level of safety. However, the reaction mechanisms are not well understood, and in particular, the discharge reaction products have not yet been identified. Here we show that zinc blende magnesium sulfide is observed as a reaction product after discharging in magnesium-sulfur batteries. When magnesium reacts electrochemically with sulfur in a sulfone-based magnesium electrolyte, sulfur becomes amorphous consisting of magnesium and sulfur in the cathode. In this study, it has been found that the amorphous material has an unusual local structure, which is not related to the most stable rock salt phase of magnesium sulfide but rather the metastable zinc blende phase. It was indicated that this material realizes the reversibility of magnesium-sulfur batteries.
<i>In vitro</i> evaluation of polyester‐based scaffolds seeded with adipose derived stem cells for peripheral nerve regeneration (2010)

To overcome the disadvantages of autografts for peripheral nerve repair, different methods such as artificial nerve conduits have been investigated for an alternative approach. This study demonstrated that solvent casting is a simple but efficient method to create thin polyester-based scaffolds for stem cell delivery. Using poly (ε-caprolactone) and poly (D,L-lactic acid), we produced scaffold films containing heterogenous depressions (pits) on the air surface with a size ranging from 0.5 to 30 μm(2). These scaffolds were moderately hydrophobic; however, they supported the differentiation of adipose derived stem cells (ADSC) into a Schwann cell-like phenotype. The differentiated ADSC (dADSC) expressed S100 protein and glial fibrillary acidic protein and readily adhered to the films and proliferated at a similar rate to those cultured on tissue culture polystyrene. Cells were also positive for proliferating cell nuclear antigen. Furthermore, dADSC retained functional activity and significantly enhanced neurite outgrowth from dorsal root ganglia neurons. This study suggests polymer scaffolds combined with dADSCs could be a promising therapy for peripheral nerve injuries.
Pinpointing Cache Timing Attacks on AES (2010)

The paper analyzes cache based timing attacks on optimized codes for Advanced Encryption Standard (AES). The work justifies that timing based cache attacks create hits in the first and second rounds of AES, in a manner that the timing variations leak information of the key. To the best of our knowledge, the paper justifies for the first time that these attacks are unable to force hits in the third round and concludes that a similar third round cache timing attack does not work. The paper experimentally verifies that protecting only the first two AES rounds thwarts cache based timing attacks.
Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription (2007)

Human immunodeficiency virus type 1 (HIV-1) transcriptional transactivator (Tat) recruits the positive transcription elongation factor b (P-TEFb) to the viral promoter. Consisting of cyclin dependent kinase 9 (Cdk9) and cyclin T1, P-TEFb phosphorylates RNA polymerase II and the negative transcription elongation factor to stimulate the elongation of HIV-1 genes. A major fraction of nuclear P-TEFb is sequestered into a transcriptionally inactive 7SK small nuclear ribonucleoprotein (snRNP) by the coordinated actions of the 7SK small nuclear RNA (snRNA) and hexamethylene bisacetamide (HMBA) induced protein 1 (HEXIM1). In this study, we demonstrate that Tat prevents the formation of and also releases P-TEFb from the 7SK snRNP in vitro and in vivo. This ability of Tat depends on the integrity of its N-terminal activation domain and stems from the high affinity interaction between Tat and cyclin T1, which allows Tat to directly displace HEXIM1 from cyclin T1. Furthermore, we find that in contrast to the Tat-independent activation of the HIV-1 promoter, Tat-dependent HIV-1 transcription is largely insensitive to the inhibition by HEXIM1. Finally, primary blood lymphocytes display a reduced amount of the endogenous 7SK snRNP upon HIV-1 infection. All these data are consistent with the model that Tat not only recruits but also increases the active pool of P-TEFb for efficient HIV-1 transcription.
Optical fibre magnetic field sensors (1980)

A class of high sensitivity fibre-optic magnetic sensors has been developed and successfully tested in the laboratory for the first time. The magnetic sensors employ magnetostrictive jacketing materials in conjunction with conventional single-mode optical fibres. An all-fibre Mach-Zender interferometer was used to detect the magnetically induced changes in optical path length which arise because of strains transferred to the fibre from the magnetostrictive jacket.
Structural formation and evolution mechanisms of fracture plugging zone (2021)

A coupled CFD-DEM method is used to simulate the formation process of fracture plugging zone. A photo-elastic system characterizing mesoscale force chain network developed by our own is used to model the pressure evolution in fracture plugging zone to reveal the evolution mechanism of the structure of fracture plugging zone. A theoretical basis is provided for improving the lost circulation control effect in fractured reservoirs and novel methods are proposed for selecting loss control materials and designing loss control formula. CFD-DEM simulation results show that bridging probability is the key factor determining the formation of fracture plugging zone and fracture plugging efficiency. Critical and absolute bridging concentrations are proposed as the key indexes for loss control formula design. With the increase of absolute bridging concentration, the governing factor of bridging is changed from material grain size to the combination of material grain size and friction force. Results of photo-elastic experiments show that mesoscale force chain network is the intrinsic factor affecting the evolution of pressure exerting on the fracture plugging zone and determines the macroscopic strength of fracture plugging zone. Performance parameters of loss control material affect the force chain network structure and the ratio of stronger force chain, and further impact the stability and strength of fracture plugging zone. Based on the study results, the loss control formula is optimized and new-type loss control material is designed. Laboratory experiments results show that the fracture plugging efficiency and strength is effectively improved.
Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice (2013)

Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. However, expressing an engineered HIV-1 long terminal repeat (LTR) site-specific recombinase (Tre), shown to excise integrated proviral DNA in vitro, may provide a novel and highly promising antiviral strategy. We report here the conditional expression of Tre-recombinase from an advanced lentiviral self-inactivation (SIN) vector in HIV-infected cells. We demonstrate faithful transgene expression, resulting in accurate provirus excision in the absence of cytopathic effects. Moreover, pronounced Tre-mediated antiviral effects are demonstrated in vivo, particularly in humanized Rag2⁻/⁻γc⁻/⁻ mice engrafted with either Tre-transduced primary CD4⁺ T cells, or Tre-transduced CD34⁺ hematopoietic stem and progenitor cells (HSC). Taken together, our data support the use of Tre-recombinase in novel therapy strategies aiming to provide a cure for HIV.
Quantitation of CD8+ T Cell Responses to Newly Identified HLA-A*0201–restricted T Cell Epitopes Conserved Among Vaccinia and Variola (Smallpox) Viruses (2003)

Immunization with vaccinia virus resulted in long-lasting protection against smallpox and was the approach used to eliminate natural smallpox infections worldwide. Due to the concern about the potential use of smallpox virus as a bioweapon, smallpox vaccination is currently being reintroduced. Severe complications from vaccination were associated with congenital or acquired T cell deficiencies, but not with congenital agammaglobulinemia, suggesting the importance of T cell immunity in recovery from infection. In this report, we identified two CD8+ T cell epitopes restricted by the most common human major histocompatibility complex (MHC) class I allele, HLA-A*0201. Both epitopes are highly conserved in vaccinia and variola viruses. The frequency of vaccinia-specific CD8+ T cell responses to these epitopes measured by interferon (IFN)-gamma enzyme-linked immunospot (ELISPOT) assay and HLA/peptide tetramer staining peaked 2 wk after primary immunization and then declined, but were still detectable 1 to 3 yr after primary immunization. 2 wk after immunization, IFN-gamma-producing cells specific to these two epitopes were 14% of total vaccinia virus-specific IFN-gamma-producing cells in one donor, 35% in the second donor, and 6% in the third donor. This information will be useful for studies of human T cell memory and for the design and analyses of the immunogenicity of experimental vaccinia vaccines.
The effect of human growth hormone-releasing factor or porcine somatotropin on serum hormones and metabolites, growth performance and carcass traits in swine. (1990)

Forty barrows (77.9 +/- 5.5 kg BW) were allotted to one of five treatment groups to examine the effects of various doses of human growth hormone-releasing factor (1-44)NH2 (hGRF) or porcine somatotropin (pST) administered twice daily on serum hormones and metabolites, performance and carcass traits. Barrows were injected s.c. with either a placebo, 10 micrograms hGRF.kg BW-1.12 h-1, 20 micrograms hGRF.kg BW-1.12 h-1, 20 micrograms pST.kg BW-1.12 h-1 or 40 micrograms pST.kg BW-1.12 h-1 for a 36-d growth trial. Blood samples were collected from 13 barrows at intervals for 360 min after injection on d 21. Compared with the placebo, 10 micrograms hGRF.kg-1.12 h-1 increased (P less than .01) serum pST and insulin and decreased (P less than .001) urea N. Injecting 20 micrograms hGRF/kg.12 h-1 elevated (P less than .001) serum pST, insulin and insulin-like growth factor-I (IGF-I) but lowered (P less than .001) urea N. Exogenous pST increased (P less than .001) serum pST, insulin, IGF-I and glucose but decreased (P less than .001) urea N. Growth rate tended to increase, and feed intake and feed/gain decreased, in a dose-related manner in response to hGRF. Also, pigs receiving 10 or 20 micrograms hGRF.kg-1.12 h-1 had reduced (P less than .1) backfat and increased (P less than .1) loineye area and percentage lean in the ham compared with pigs receiving the placebo. At equal doses, pST elicited more dramatic improvements in performance and carcass criteria than did hGRF.(ABSTRACT TRUNCATED AT 250 WORDS)
Using photonic crystals as optical fibers (2002)

By designing and fabricating optical fibers using photonic crystal materials as cladding, one can create fibers with previously unimaginable waveguiding properties. The development of photonic crystal fiber substantially broadens the possible applications for fiber optics.