gebhart/patrepeval huggingface dataset:
Methodologies for uncertainty management in prognostics (2009)

Effective uncertainty management processes are essential elements in the design of prognostic modules if they to be viable for Integrated Vehicle Health Management (IVHM) systems. Modeling uncertainty, measurement and estimation uncertainties, future load uncertainty, among other factors, all potentially contribute to prognostic uncertainty. This paper analyzes the source of uncertainties in typical IVHM systems and presents a rigorous set of algorithms for uncertainty management that are generic and capable of addressing a variety of uncertainty sources. Specifically, model parameter uncertainty is addressed by a Bayesian-based updating scheme with two variants. One approach utilizes an inner-outer loop Monte Carlo simulation scheme with hyper-parameter adaptation and is intended for off-line applications, while the other particle filtering-based approach can be implemented on-line in real-time. Modeling uncertainty (or model structure uncertainty) is addressed by a Bayesian model selection/fusion method. Effective approaches for handling diagnostic uncertainty and the aggregation of component level uncertainty to system level are also addressed. Select results for the application of particular algorithms are presented.
Better nonparametric bootstrap confidence intervals for the correlation coefficient (1989)

We respond to criticism leveled at bootstrap confidence intervals for the correlation coefficient by recent authors by arguing that in the correlation coefficient case, non–standard methods should be employed. We propose two such methods. The first is a bootstrap coverage coorection algorithm using iterated bootstrap techniques (Hall, 1986; Beran, 1987a; Hall and Martin, 1988) applied to ordinary percentile–method intervals (Efron, 1979), giving intervals with high coverage accuracy and stable lengths and endpoints. The simulation study carried out for this method gives results for sample sizes 8, 10, and 12 in three parent populations. The second technique involves the construction of percentile–t bootstrap confidence intervals for a transformed correlation coefficient, followed by an inversion of the transformation, to obtain “transformed percentile–t” intervals for the correlation coefficient. In particular, Fisher's z–transformation is used, and nonparametric delta method and jackknife variance estimates are used to Studentize the transformed correlation coefficient, with the jackknife–Studentized transformed percentile–t interval yielding the better coverage accuracy, in general. Percentile–t intervals constructed without first using the transformation perform very poorly, having large expected lengths and erratically fluctuating endpoints. The simulation study illustrating this technique gives results for sample sizes 10, 15 and 20 in four parent populations. Our techniques provide confidence intervals for the correlation coefficient which have good coverage accuracy (unlike ordinary percentile intervals), and stable lengths and endpoints (unlike ordinary percentile–t intervals).
The Serous Cell (1990)

Mitochondrial fatty acid β-oxidation (FAO) is the major pathway for the degradation of fatty acids and is essential for maintaining energy homeostasis in the human body. Fatty acids are a crucial energy source in the postabsorptive and fasted states when ...Read More
CRISPR–Cas adaptation in Escherichia coli requires RecBCD helicase but not nuclease activity, is independent of homologous recombination, and is antagonized by 5′ ssDNA exonucleases (2018)

Prokaryotic adaptive immunity is established against mobile genetic elements (MGEs) by 'naïve adaptation' when DNA fragments from a newly encountered MGE are integrated into CRISPR-Cas systems. In Escherichia coli, DNA integration catalyzed by Cas1-Cas2 integrase is well understood in mechanistic and structural detail but much less is known about events prior to integration that generate DNA for capture by Cas1-Cas2. Naïve adaptation in E. coli is thought to depend on the DNA helicase-nuclease RecBCD for generating DNA fragments for capture by Cas1-Cas2. The genetics presented here show that naïve adaptation does not require RecBCD nuclease activity but that helicase activity may be important. RecA loading by RecBCD inhibits adaptation explaining previously observed adaptation phenotypes that implicated RecBCD nuclease activity. Genetic analysis of other E. coli nucleases and naïve adaptation revealed that 5' ssDNA tailed DNA molecules promote new spacer acquisition. We show that purified E. coli Cas1-Cas2 complex binds to and nicks 5' ssDNA tailed duplexes and propose that E. coli Cas1-Cas2 nuclease activity on such DNA structures supports naïve adaptation.
Biologically Active Oligodeoxyribonucleotides. X. Anti-HIV-1 Activity and Stability of Modified Hexanucleotides Containing Glycerol-Skeleton (1998)

Deoxyribose-moieties of modified hexadeoxyribonucleotide 1, which exhibits anti-HIV-1 activity, were partially replaced with glycerol-moieties. Compound 7 with two glycerylguanines at its 3'-end showed more potent anti-HIV-1 activity and more stability against digestion by nucleases than the parent compound 1.
Continuing rollout of Local Drug Action Teams across Australia (2018)

The Australian Government is continuing to take action to combat the scourge of ice and other illicit drugs with more Local Drug Action Teams set to rollout across Australia.
A New Ligand for Immunoglobulin G Subdomains by Screening of a Synthetic Peptide Library (2005)

By screening a synthetic peptide library of general formula (NH(2)-Cys1-X2-X3-X4)(2)-Lys-Gly-OH, a disulfide-bridged cyclic peptide, where X2-X3-X4 is the tripeptide Phe-His-His, has been selected as a ligand for immunoglobulin G (IgG). The peptide, after a preliminary chromatographic characterization, has proved useful as a new affinity ligand for the purification of polyclonal as well as monoclonal antibodies from biological fluids, with recovery yields of up to 90% (90% purity). The ligand is able to bind antibody fragments containing both Fab and Fc from different antibody isotypes, a fact suggesting the presence of at least two different antibody-binding sites. While the recognition site on Fab is unknown, comparative binding studies with Fc, in association with the striking similarities of the peptide (named Fc-receptor mimetic, FcRM) with a region of the human FcgammaRIII receptor, strongly indicate that the peptide could recognize a short amino acid stretch of the lower hinge region, which has a key role in autoimmune disease triggering. The unique properties make the ligand attractive for both the purification of antibody fragments and as a lead for the generation of Fc-receptor antagonists.
Measuring the Nonuniform Evaporation Dynamics of Sprayed Sessile Microdroplets with Quantitative Phase Imaging (2015)

We demonstrate real-time quantitative phase imaging as a new optical approach for measuring the evaporation dynamics of sessile microdroplets. Quantitative phase images of various droplets were captured during evaporation. The images enabled us to generate time-resolved three-dimensional topographic profiles of droplet shape with nanometer accuracy and, without any assumptions about droplet geometry, to directly measure important physical parameters that characterize surface wetting processes. Specifically, the time-dependent variation of the droplet height, volume, contact radius, contact angle distribution along the droplet's perimeter, and mass flux density for two different surface preparations are reported. The studies clearly demonstrate three phases of evaporation reported previously: pinned, depinned, and drying modes; the studies also reveal instances of partial pinning. Finally, the apparatus is employed to investigate the cooperative evaporation of the sprayed droplets. We observe and explain the neighbor-induced reduction in evaporation rate, that is, as compared to predictions for isolated droplets. In the future, the new experimental methods should stimulate the exploration of colloidal particle dynamics on the gas-liquid-solid interface.
Video transmission scheduling for peer-to-peer live streaming systems (2008)

For Internet based video broadcasting applications such as IPTV, the peer-to-peer (P2P) streaming scheme has been found to be an effective solution. An important issue in live broadcasting is to avoid playback buffer underflow. How to utilize the playback buffer and upload bandwidth of peers to minimize the freeze-ups in playback, is the problem we try to solve. In this work, we propose a successive water-filling (SWaF) algorithm for the video transmission scheduling in P2P live streaming system, to minimize the playback freeze-ups among peers. SWaF algorithm only needs each peer to optimally transmit (within its uploading bandwidth) part of its available video segments in the buffer to other peers requiring the content and pass small amount message to some other peers. Moreover, SWaF has low complexity and provable optimality. Numerical results demonstrated the effectiveness of the proposed algorithm.
A Comprehensive Survey on Parallelization and Elasticity in Stream Processing (2019)

Stream Processing (SP) has evolved as the leading paradigm to process and gain value from the high volume of streaming data produced, e.g., in the domain of the Internet of Things. An SP system is a middleware that deploys a network of operators between data sources, such as sensors, and the consuming applications. SP systems typically face intense and highly dynamic data streams. Parallelization and elasticity enable SP systems to process these streams with continuous high quality of service. The current research landscape provides a broad spectrum of methods for parallelization and elasticity in SP. Each method makes specific assumptions and focuses on particular aspects. However, the literature lacks a comprehensive overview and categorization of the state of the art in SP parallelization and elasticity, which is necessary to consolidate the state of the research and to plan future research directions on this basis. Therefore, in this survey, we study the literature and develop a classification of current methods for both parallelization and elasticity in SP systems.
The Rental (Assistance) Crisis (2009)

Ask any renters who have moved house in the past year and they will tell you it's increasingly difficult to secure a property, let alone find one that is well located and affordable. This article discusses the state of the rental market and what the government can do about it.
Rainbow trout protamines. Amino acid sequences of six distinct proteins from a single testis (1986)

All the protamines present in detectable amounts in a single mature testis from rainbow trout have been purified to homogeneity using acid extraction, gel filtration chromatography on Bio-Gel P-10, ion-exchange chromatography on carboxymethylcellulose and reverse-phase high-pressure liquid chromatography. Each of the six purified protamines was completely sequenced using automated gas-phase Edman degradation. Each protamine is two-thirds arginine and also contains proline, serine, valine and glycine. Three protamines also contain alanine while two contain isoleucine. Four of the protamines have 32 amino acids while the remaining two have 30. The six protamines have been classified into three families on the basis of their amino acid sequences.
IntEnz, the integrated relational enzyme database (2003)

IntEnz is the name for the Integrated relational Enzyme database and is the official version of the Enzyme Nomenclature. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Bio chemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at http://www.ebi.ac.uk/intenz.
Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. (1993)

New protein synthesis appears to contribute to ischemic cell death in which endonucleolytic DNA degradation is apparent. These observations implicate programmed cell death in ischemic injury and may open unique therapeutic approaches for the preservation of neurons in stroke.
Fluidized bed incineration system for U. S. Department of Energy Defense Waste, January--June 1978 (1978)

A fluidized bed incineration facility has been designed for installation at the Rocky Flats Plant to develop and demonstrate the process for the combustion of transuranic waste. The unit capacity will be about 82 kg/hour of combustible waste. The combustion process will utilize in situ neutralization of acid gases generated in the process. The equipment design is based on data generated on a pilot scale unit and represents a scale-up factor of nine. Equipment installation was completed on April 30, 1978. Equipment checkout and startup is in progress.
A Single-Crystal-Silicon Bulk-Acoustic-Mode Microresonator Oscillator (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A timing reference incorporating a single-crystal-silicon micromechanical resonator with a quality factor of larger than one million and a resonant frequency of 2.18 MHz is demonstrated. The resonator is excited in the square extensional bulk acoustic mode at 4 mtorr, and it has been fabricated in a foundry SOI MEMS process. The silicon microresonator is adapted as a timing element for a precision oscillator with a measured short-term Allan deviation of 0.6 ppb. </para>
Effects Of Multi Walled Carbon Nanotubes And Graphene On The Mechanical Properties Of Hybrid Polymer Composites (2013)

A small amount of Graphene and Multi walled carbon nanotubes (MWCNT) by direct mixing were employed to disperse these nanoparticles into a mono-component epoxy system and used as matrix for advanced composites with woven Glass and Carbon fiber reinforcements. These nanoparticles were added directly into the hosting system and dispersion was carried out by using mechanical stirring. In this study the hybrid polymer composite with Glass fiber, Carbon fiber and epoxy polymer in the ratio of 9:12.5:78.5, 13.5:18.75:67.75 and 18:25:57 percent of volume with addition of fillers, Graphene (0.2 wt%) and MWCNT (0.2wt%) have been developed. The mechanical characterization results confirm that the composite developed by using graphene nanoparticles represents a fundamental feature in enhancing the tensile elastic modulus and hardness behavior of the composite system, where as MWCNT has significant effect on the bending modulus and impact behavior. The optical microscopic study for the fractured samples reveals a significant increase in the fiber-matrix interface adhesion where as decrease in fiber breakage, fiber pullout and debonding.
Morphology of a lamellar diblock copolymer aligned perpendicular to the sample plane: transmission electron microscopy and small-angle X-ray scattering (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMorphology of a lamellar diblock copolymer aligned perpendicular to the sample plane: transmission electron microscopy and small-angle X-ray scatteringKaren I. Winey, Sanjay S. Patel, Ronald G. Larson, and Hiroshi WatanabeCite this: Macromolecules 1993, 26, 16, 4373–4375Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ma00068a047https://doi.org/10.1021/ma00068a047research-articleACS PublicationsRequest reuse permissionsArticle Views386Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Feasibility Study with Image-Based Rendered Virtual Reality in Patients with Mild Cognitive Impairment and Dementia (2016)

Virtual Reality (VR) has emerged as a promising tool in many domains of therapy and rehabilitation, and has recently attracted the attention of researchers and clinicians working with elderly people with MCI, Alzheimer's disease and related disorders. Here we present a study testing the feasibility of using highly realistic image-based rendered VR with patients with MCI and dementia. We designed an attentional task to train selective and sustained attention, and we tested a VR and a paper version of this task in a single-session within-subjects design. Results showed that participants with MCI and dementia reported to be highly satisfied and interested in the task, and they reported high feelings of security, low discomfort, anxiety and fatigue. In addition, participants reported a preference for the VR condition compared to the paper condition, even if the task was more difficult. Interestingly, apathetic participants showed a preference for the VR condition stronger than that of non-apathetic participants. These findings suggest that VR-based training can be considered as an interesting tool to improve adherence to cognitive training in elderly people with cognitive impairment.
Four novel mutations of the PKD2 gene in czech families with autosomal dominant polycystic kidney disease (2002)

Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disease caused by mutations in at least three different loci. Mutations in the PKD2 gene are responsible for approximately 15% of the cases of the disease. We have screened 14 Czech families for mutation in the PKD2 gene. Clear evidence against linkage to the PKD1 gene was established by CA-repeat markers in five families. The disease could be linked to both genes according to linkage analysis in nine families but we have chosen these families because of the mild clinical course. An affected member from each family was analyzed by heteroduplex analysis (HA) and single strand conformation polymorphism (SSCP) for all 15 coding regions. Samples exhibiting shifted bands on HA or SSCP gels were sequenced. We detected five mutations (four new, and one which was previously described) and two polymorphisms. The four new mutations include one insertion, one deletion, one substitution (leading to premature translation stop), one amino acid substitution. Our results confirm that different point or small changes distributed throughout the PKD2 gene without clustering are responsible for the disease.
Loss of Marek's disease virus tumorigenicity is associated with truncation of RNAs transcribed within BamHI-H (1989)

The attenuation of Marek's disease virus (MDV) is associated with loss of pathogenicity and tumorigenicity. Previous studies have demonstrated a strong correlation between attenuation and amplification of a specific sequence located within the MDV terminal and internal repeats. We recently reported that the regions containing the amplified sequences, the BamHI D and H fragments, were transcriptionally active. However, differential transcription activity was observed to exist between attenuated and pathogenic MDV strains. Specifically, a major transcript of 1.8 kilobases was found to be produced by pathogenic MDV and not by attenuated MDV. We now report that the disappearance of this transcript is concomitant with the production of a 0.4-kilobase RNA, an RNA resulting from the truncation of the tumorigenicity-related transcript.
Augmented reality, the future of contextual mobile learning (2016)

Purpose This study aims to show the relevance of augmented reality (AR) in mobile learning for the 21st century. With AR, any real-world environment can be augmented by providing users with accurate digital overlays. AR is a promising technology that has the potential to encourage learners to explore learning materials from a totally new perspective. Besides, the advancements made in information technology further broaden the scope for educational AR applications. Furthermore, the proliferation of wireless mobile devices such as smartphones and tablets is also introducing AR into the mobile domain. Design/methodology/approach This discussion paper gives an insight of the different potential fields of application of AR and eventually proposes an AR application that will give a completely different learning experience for learners. This AR mobile application will not only provide learners with supplementary information but will also assist lecturers in their teaching process. There are certain concepts in computer science at the tertiary level that are at times difficult for learners to understand using the traditional classroom approach. Through this AR application developed, the learners are able to see what is happening and experience a different form of learning where the focus is more on “learning by doing” and on the ability of visualizing the complete set of steps involved for a particular operation. Finally what is proposed is a generic framework/process for the development of AR applications for learning purposes. Findings The AR application developed and tested has proved to be helpful in understanding complex concepts of computer science that average students have much difficulty in understanding. Through AR, learning has been brought to a new dimension where the students can easily visualize what is happening and easily understand complex concepts. This low-cost system that has been proposed can track and detect both markerless and marker-based images. A number of experiments have also been carried out to determine a set of best practices for the development and use of such AR applications. Originality/value Learners have been able to have a more interactive and enriching learning experience through two-dimensional and three-dimensional digital augmentations. The AR mobile application has been enhancing the cognitive skills of learners through enabling them to scan images from printed materials with their smartphones. Then, informative digital augmentation has been overlaid in real time on the mobile screen with the image preview still in the background.