gebhart/patrepeval huggingface dataset:
Dendritic Cells Pulsed with Polyomavirus BK Antigen Induce Ex Vivo Polyoma BK Virus–Specific Cytotoxic T-Cell Lines in Seropositive Healthy Individuals and Renal Transplant Recipients (2003)

Polyoma BK virus (BKV)-associated interstitial nephritis has emerged as a relevant complication of immunocompromise after kidney transplantation, leading to reduced survival of the renal allograft. The limitations of current antiviral treatment and the high probability of rejection in kidney graft recipients when control of viral replication is attempted by reduction of immunosuppression warrant further efforts to develop alternative therapeutic tools. Cellular immunotherapy has proved to be a successful approach for prevention and/or treatment of other viral complications in the immunocompromised host. For assessing the feasibility of translating this strategy to the prevention of BKV-associated disease, a procedure for ex vivo reactivation of BKV-specific cytotoxic T cells (CTL) was developed from BKV-seropositive healthy donors and allograft recipients through stimulation with dendritic cells pulsed with inactivated BKV. The CTL lines thus obtained showed BKV specificity, as an efficient lysis of BKV-infected targets was accompanied by little or no reactivity against mock-infected autologous or allogeneic targets. In vitro killing of allogeneic BKV-infected targets, likely as a result of populations of TCRgammadelta+/CD3+ displaying MHC class I unrestricted cytotoxicity, was also displayed. Application of this culture system may allow a preemptive therapy approach to BKV-related complications in transplant recipients, based on CTL treatment guided by BKV DNA levels.
Effect of Heat on the Soundness of Zircaloy-4 End Cap Closure Using a Resistance Upset Welding (2010)

The objective of this study is to investigate the effect of main heat on the soundness of Zircaloy-4 end cap welds and the process of weld line elimination in resistance upset welding for a Direct Use of spent PWR fuel In CANDU reactor (DUPIC) fuel fabrication. The weld current and amount of upset increased linearly with the main heat, from which two relations between them were derived. It was found that the threshold to obtain sound welds was 50% of the main heat in terms of upset size, mechanical strength, and weld line elimination. A microstructure of resistance upset welds of Zircaloy-4 comprised basketweave, Widmanstätten, and martensite depending on the alteration of the main heats. Dimples on the uniaxially fractured surface at the weld line in Zircaloy-4 welds were larger and deeper than those on a biaxially fractured surface. It was also found that the process of weld line elimination in the resistance upset weld of Zircaloy-4 could be divided into three stages in terms of the presence of many pores, their shrinkage and elimination, and the shrinkage of the original weld interface with increasing weld current.
<i>Pneumocystis jirovecii</i> pneumonia after rituximab therapy for antibody‐mediated rejection in a renal transplant recipient (2008)

We report the case of a 54-year-old woman who underwent living-related renal transplantation for end-stage renal disease from IgA nephropathy. She was subsequently diagnosed with antibody-mediated rejection (AMR) and received rituximab, a potent B-cell suppressive agent. After therapy with rituximab, she developed Pneumocystis jirovecii pneumonia (PJP) requiring hospitalization. We discuss the increasing literature for the use of rituximab for AMR and the need for PJP prophylaxis in this setting.
Adaptive Data Transmission Control for Multilane-Based Ethernet (2013)

We propose a reconciliation sublayer (RS)-based lane and traffic control protocol for energy-efficient 40-G/100-G Ethernet. The RS performs active/inactive lane control and data rate adaptation depending on active lane information received from the upper layer. This protocol does not result in a processing delay in the media access control layer, nor is an additional buffer required at the physical layer for dynamic lane control. It ensures minimal delay and no overhead for the exchange of control frames and provides a simple adaptive data rate.
Calculating the usage probabilities of statistical usage models by constraints optimization (2010)

The systematic generation of test cases from statistical usage models has been investigated recently for specific application domains, such as wireless communications or automotive applications. For Markov chain usage models, the expected usage of a hardware/software system is represented by transitions between usage states and a usage profile, meaning probability values that are attached to the state transitions.In this paper, we explain how to calculate the profile probabilities for the Markov chain usage model from a set of linear usage constraints and by optimizing a convex polyhedron that represents the constrained solution space. Comparing the computed probability distributions of our polyhedron approach with the maximum entropy technique, which is the main technique used so far, illustrates that our results are more obvious to the intented constraint semantics. In order to demonstrate the applicability of our approach, workflow testing of a complex RIS/PACS system in the medical domain was carried through and has provided promising results.
Refining Micro Services Placement over Multiple Kubernetes-orchestrated Clusters employing Resource Monitoring (2020)

In the cloud field, there is an increasing demand for globalized services and corresponding execution environments that overcome local limitations and selectively utilize optimal resources. Utilizing multi-cloud deployments and operations rather than using a single cloud is an effective way to satisfy the increasing demand. In particular, we need to provide cloud-native environment to organically support services based on a microservices architecture. In this paper, we propose a cloud-native workload profiling system with Kubernetes-orchestrated multi-cluster configuration. The contributions of this paper are as follows. (i) We design the operating software over multiple cloud-native cluster to select optimal resources by monitoring. (ii) For operating the multiple clusters through the design, we define and design specific general service workloads. Also, we implement the workloads in application software (iii) To seek optimal resources, we deployed the general workloads and monitored resource usage repeatedly in detail. We calculate resource variation in comparison with initial resource usage and average resource usage after deploying the service workloads. Also, we analyze the resource monitoring result. We expect this methodology can find proper resources for service workload types.
Peningkatan Daya Listrik Pada Generator Putaran Rendah Melalui Peningkatan Sifat Magnetik Magnet Permanen Bafe12o19 (2020)

AbstrakGenerator adalah suatu alat atau sistem yang dapat mengubah tenaga mekanis menjadi tenaga listrik dan menghasilkan tenaga listrik bolak-balik atau tenaga listrik searah tergantung pada tipe generator. Umumnya magnet yang digunakan pada Generator putaran rendah adalah NdFeB, yang sulit diperoleh unsur-unsur pembentuknya, maka digunakan bahan BaFe12O19 sebagai magnet alternatif. Tujuan penelitian ini adalah untuk memperoleh sifat magnetik tertinggi pada BaFe12O19 melalui variasi perlakuan sinter. Metodologi yang digunakan pada penelitian ini yaitu menggunakan metode sol-gel, dengan pengujian karakteristik serbuk yaitu permagraph,XRD dan SEM. Parameter yang digunakan yaitu pada temperatur sinter 750ºC, 800ºC dan 850ºC, masing-masing dilakukan selama 8,10,12 jam. Hasil penelitian menunjukkan bahwa untuk menghasilkan daya listrik yang tinggi pada generator dapat digunakan BaFe12O19 dengan rasio mol Ba:Fe = 1:12 dengan kondisi temperatur sinter 850°C dan waktu sinter 12 jam. Pada kondisi tersebut dihasilkan energi magnetik terbesar (89,019 T.kA/m) dan serbuk dalam kondisi fasa tunggal (100% BaFe12O19).Kata kunci: Generator, Magnet Permanen, Metode Sol-Gel, BaFe12O19Abstract A generator is a device or system that can convert mechanical power into electric power and produce alternating electric power or electric power in the direction of the type of generator. Generally the magnet used in the low speed generator is NdFeB, which is difficult to obtain by its constituent elements, so BaFe12O19 is used as an alternative magnet. The purpose of this study was to obtain the highest magnetic properties on BaFe12O19 through variations of sintered treatment. The methodology used in this study is using the Sol-Gel Method, by testing powder characteristics, namely Permagraph, XRD and SEM. The parameters used were sintered temperatures of 750ºC, 800ºC and 850ºC, each carried out for 8,10.12 hours. The results showed that BaFe12O19 with a high mol ratio Ba: Fe = 1:12 to produce high electrical power at the generator with conditions sintered 850 ° C and sintered time 12 hours. In this condition, the largest magnetic energy (89,019 T.kA / m) and powder were produced under single phase conditions (100% BaFe12O19).Keywords: Generator, Permanent Magnet, Sol-Gel Method, BaFe12O19
Aza‐Analogs of 8‐Styrylxanthines as A<sub>2A</sub>‐Adenosine Receptor Antagonists (1997)

In the present study we synthesized aza-analogs of 8-styrylxanthines, in which the ethenyl bridge is replaced by an imine, amide, or azo function, in order to investigate structure-activity relationships of the 8-substituent of A2A-selective xanthine derivatives. Thus, various 8-substituents were combined with theophylline or caffeine, respectively, and affinities of the novel compounds for adenosine A1- and A2a-receptors were determined and compared with those of analogous 8-styrylxanthine derivatives. 8-(Benzylideneamino)caffeine derivatives exhibited high affinity and selectivity for A2A-adenosine receptors, but were unstable in aqueous buffer solution at physiological pH values. 8-(Phenylazo)caffeine derivatives were less potent than corresponding 8-styrylcaffeine derivatives at adenosine receptors. The most potent azo compound of the present series was 8-(m-chlorophenylazo)caffeine (14b) exhibiting a Ki value of 400 nM at A2A-adenosine receptors and 20-fold selectivity versus A1-receptors. Due to the facile synthetic access to 8-(phenylazo)xanthine derivatives, which are obtained by coupling of 8-unsubstituted xanthines with phenyldiazonium salts, 14b may be an interesting new lead compound for the development of more potent and selective A2A-antagonists with azo structure.
Automated cost-aware data center management (2006)

Modern data centers present complex management challenges, including resource provisioning, workload placement, thermal and power management, and failure detection and response. However, these challenges are not well-suited to direct control by a human operator. Expanding the scope of automated control can improve operating efficiencies, reduce the total cost of ownership, and increase system reliability. Automated control of a modern data center requires accurate thermal instrumentation, models of data center component behavior, and information about operating costs. 
The contributions of this work are policies and mechanisms for cost-aware automated data center management. We outline an optimizing control loop architecture that leverages statistical and machine learning techniques to formulate resource control plans. There are four primary components to our work that demonstrate the principles of cost-aware data center control. First, we create a utility computing infrastructure that enables multiplexed hosting of services by provisioning and isolating blocks of servers from a shared cluster. Next, we provide accurate and fine-grained thermal instrumentation using machine learning-based models of heat transfer within a server; this allows us to quantify the per-server relationship between ambient air temperature, workload, and internal temperature readings. Using this data, we construct models to analyze and predict the effects of management decisions on total data center operating costs. Finally, we formulate cost-aware provisioning policies that enable quantitative trade-offs between competing management goals. 
Our results demonstrate the effectiveness of automated, cost-aware control. ConSil, our thermal instrumentation layer, provides current per-server temperature readings that are accurate to 1.0°C over 80% of readings. Weatherman predicts steady state thermal conditions across the data center using the current workload and cooling configuration with an accuracy of 1.0°C for over 90% of locations. Finally, we explore workload placement policies that optimize cooling costs; our two policies result in a 25% reduction in cooling costs at standard utilization levels for a representative data center. These components enable the site owner to define high-level policies, while relegating complex, low-level trade-offs to the automated controller.
Chemical synthesis of the hexasaccharide related to the repeating unit of the capsular polysaccharide from carbapenem resistant Klebsiella pneumoniae 2796 and 3264 (2016)

Total synthesis of the hexasaccharide repeating unit of the capsular polysaccharide from<italic>Klebsiella pneumoniae</italic>2796 and 3264 following a linear sequential glycosylation strategy.
Abstract 174: Development of a Novel Anti-inflammatory and Anti-osteoplastic Peptide Based on De-loop and Ef-loop in Rankl for Treatment of Ischemic Stroke (2016)

Background & Purpose: We previously showed that stimulation of RANKL (receptor activator of nuclear factor-B ligand)/ RANK (receptor for RANKL) signal with recombinant RANKL worked as protective in ischemic brain through inhibiting TLR signaling pathways. However, augmentation of RANK signaling is also causative for increasing osteoclast differentiation and osteoporosis. To overcome the problem, we developed a novel RANKL-based peptide, which is anti-inflammatory and anti-osteoclastic. Methods: We made four peptides: MHP1 with complete DE loop and 66.7% of EF loop including complete βE and 72.3% of βD; MHP2 with complete DE loop, 22.2% of EF loop, and 10% of CD loop including complete βE and βD; MHP3 including complete CD loop and DE loop including complete βD; MHP4 including complete DE loop and βD. The action of the peptides were evaluated in MG6 cells, RAW 264.7 cells, primary osteoclast precursor cells, and 40 min-transient cerebral artery occlusion (tMCAo) model in C57BL6/J mice. Results: In LPS-stimulated MG6 and/or RAW 264.7 cells, MHP1 and MHP2 inhibited expression of IL-6 and TNFα, whereas MHP3 and 4 showed no effects. Knocking down of RANK revealed that the effects of MHP1 was dependent on RANK signaling, indicating that some components of DE loop, EF loop, βD, and βE in RANKL were required to show the anti-inflammatory effects in TLR4-induced inflammation. The anti-inflammatory effect was also effective in TLR2/6-induced inflammation but not RAGE-dependent inflammation, suggesting that effects of MHP1 might be specific TLRs signaling. In primary osteoclast precursor cells, MHP1 did not stimulate osteoclast differentiation and also inhibited RANKL-induced osteoclast differentiation. In the ischemic mice, the i.c.v. injection of MHP1 at 4 hrs after the ischemia showed less infarct volume and less activated microglia/macrophages in ischemic brain at 72 hrs after ischemia. Conclusions: Thus, MHP1 has a unique property, such as stimulation of RANK related anti-inflammatory signaling with inhibitory effects for RANK-induced osteoclast differentiation. This indicated that MHP1 could be one of novel candidates for preventing inflammation and osteoporosis in ischemic stroke.
Hypothesis: lipoprotein(a) is a surrogate for ascorbate. (1990)

The concept that lipoprotein(a) [Lp(a)] is a surrogate for ascorbate is suggested by the fact that this lipoprotein is found generally in the blood of primates and the guinea pig, which have lost the ability to synthesize ascorbate, but only rarely in the blood of other animals. Properties of Lp(a) that are shared with ascorbate, in accordance with this hypothesis, are the acceleration of wound healing and other cell-repair mechanisms, the strengthening of the extracellular matrix (e.g., in blood vessels), and the prevention of lipid peroxidation. High plasma Lp(a) is associated with coronary heart disease and other forms of atherosclerosis in humans, and the incidence of cardiovascular disease is decreased by elevated ascorbate. Similar observations have been made in cancer and diabetes. We have formulated the hypothesis that Lp(a) is a surrogate for ascorbate in humans and other species and have marshaled the evidence bearing on this hypothesis.
Liquid chromatography/mass spectrometry (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid chromatography/mass spectrometryThomas R. Covey, Edgar D. Lee, Andries P. Bruins, and Jack D. HenionCite this: Anal. Chem. 1986, 58, 14, 1451A–1461APublication Date (Print):December 1, 1986Publication History Published online22 September 2008Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/ac00127a001https://doi.org/10.1021/ac00127a001research-articleACS PublicationsRequest reuse permissionsArticle Views3981Altmetric-Citations215LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synaptojanin 1 Mutation in Parkinson’s Disease Brings Further Insight into the Neuropathological Mechanisms (2014)

Synaptojanin 1 (SYNJ1) is a phosphoinositide phosphatase highly expressed in nerve terminals. Its two phosphatase domains dephosphorylate phosphoinositides present in membranes, while its proline-rich domain directs protein-protein interactions with synaptic components, leading to efficient recycling of synaptic vesicles in neurons. Triplication of SYNJ1 in Down's syndrome is responsible for higher level of phosphoinositides, enlarged endosomes, and learning deficits. SYNJ1 downregulation in Alzheimer's disease models is protective towards amyloid-beta peptide (Aβ) toxicity. One missense mutation in one of SYNJ1 functional domains was recently incriminated in an autosomal recessive form of early-onset Parkinson's disease (PD). In the third decade of life, these patients develop progressive Parkinsonism with bradykinesia, dystonia, and variable atypical symptoms such as cognitive decline, seizures, and eyelid apraxia. The identification of this new gene, together with the fact that most of the known PD proteins play a role in synaptic vesicle recycling and lipid metabolism, points out that synaptic maintenance is a key player in PD pathological mechanisms. Studying PD genes as a network regulating synaptic activity could bring insight into understanding the neuropathological processes of PD and help identify new genes at fault in this devastating disorder.
3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas (2021)

The possibility to quantitatively study specific molecular/cellular features of complete human organs with preserved spatial 3D context would have widespread implications for pre-clinical and clinical medicine. Whereas optical 3D imaging approaches have experienced a formidable revolution, they have remained limited due to current incapacities in obtaining specific labelling within large tissue volumes. We present a simple approach enabling reconstruction of antibody labeled cells within entire human organs with preserved organ context. We demonstrate the utility of the approach by providing volumetric data and 3D distribution of hundreds of thousands of islets of Langerhans within the human pancreas. By assessments of pancreata from non-diabetic and type 2 diabetic individuals, we display previously unrecognized features of the human islet mass distribution and pathology. As such, this method may contribute not only in unraveling new information of the pancreatic anatomy/pathophysiology, but it may be translated to essentially any antibody marker or organ system.
Electronic Tuning of Misaligned Coils in Wireless Power Transfer Systems (2014)

The misalignment and displacement of inductively coupled coils in a wireless power transfer system (WPT) can degrade the power efficiency and limit the amount of power that can be transferred. Coil misalignment leads the primary coil driver to operate in an untuned state which causes nonoptimum switching operation and results in an increase in switching losses. This paper presents a novel method to electronically tune a Class-E inverter used as a primary coil driver in an inductive WPT system to minimize the detrimental effects of misalignment between the inductively coupled coils which may occur during operation. The tuning method uses current-controlled inductors (saturable reactors) and a variable switching frequency to achieve optimum switching conditions regardless of the misalignment. Mathematical analysis is performed on a Class-E inverter based on an improved model of a resonant inductive link. Experimental results are presented to confirm the analysis approach and the suitability of the proposed tuning method.
<title>Two-dimensional detection of optoacoustic stress transients</title> (2002)

For enhanced optoacoustic imaging in biomedical applications more than one-dimensional detection is required. Tomographic images comparable to ultrasound B-scans can be generated with linear arrays. This work presents a detection scheme for such an array based on piezoelectric films. Each single detector consists of a ring shaped active area with a diameter of less than one millimeter, which leads to a high lateral resolution. Because of the small dimensions of the systems it is suitable for applications with limited accessibility like ophthalmic or endoscopic use. The sensitivity of a single detector is close to 0.5 mV/bar. First measurements on layered tissue phantoms made of gelatine and absorbing films show the potential of such an array for depth profiling as well as for two-dimensional imaging of simple structures.
Water, hydration, and health (2010)

This review examines the current knowledge of water intake as it pertains to human health, including overall patterns of intake and some factors linked with intake, the complex mechanisms behind water homeostasis, and the effects of variation in water intake on health and energy intake, weight, and human performance and functioning. Water represents a critical nutrient, the absence of which will be lethal within days. Water's importance for the prevention of nutrition-related noncommunicable diseases has received more attention recently because of the shift toward consumption of large proportions of fluids as caloric beverages. Despite this focus, there are major gaps in knowledge related to the measurement of total fluid intake and hydration status at the population level; there are also few longer-term systematic interventions and no published randomized, controlled longer-term trials. This review provides suggestions for ways to examine water requirements and encourages more dialogue on this important topic.