gebhart/patrepeval huggingface dataset:
Abstract 1845: Adult Cardiac Progenitor Cells Promote Angiogenesis and Cardioprotection through Their Secreted Soluble Vcam-1 (2008)

Although cardiac progenitor cells have been thought to be the promising source of cell therapy, the precise mechanisms of their paracrine action have not been fully elucidated. Since we observed that the transplantation of clonal expanded Sca-1 positive cardiac progenitor cells (cSca-1 cells) derived from adult murine heart by using cell sheet technique improved cardiac function of infarcted heart compared to adipose tissue derived mesenchymal cells (ATMC), we explored the secreted factors highly expressed in cSca-1 cells and identified that soluble VCAM-1 (sVCAM-1) was much abundant in cSca-1 cells compared to ATMC by using cytokine antibody array. cSca-1 cells-derived conditioned medium (CM) significantly enhanced endothelial migration and matrigel tube formation and these effects were abolished by knock down of VCAM-1 (Fold increase: control, 1.0; CM, 2.97 ± 0.21; siVCAM-1, 1.98 ± 0.09; siControl, 2.76 ± 0.05, p<0.01), suggesting that cSca-1 cells promote angiogenesis via their secreted sVCAM-1. We next examined whether sVCAM-1 conferred direct protective effects on cardiomyocytes. We exposed cardiomyocytes to 0.2 mM H 2 O 2 in the absence or presence of sVCAM-1 or CM and examined cardiomyocyte viability by MTT assay. The exposure of cardiomyocytes to H 2 O 2 significantly induced the cell injury. Interestingly when pretreated with sVCAM-1 or CM, the cell damages of cardiomyocytes by H 2 O 2 were significantly reduced. However when pretreated with anti-VLA4 antibody, a principal coreceptor of sVCAM-1, CM mediated cell protected effect was completely inhibited (Fold increase: control, 1.0; anti-VLA4, 0.89 ± 0.33; sVCAM-1, 1.69 ± 0.27; CM, 2.08 ± 0.28; CM+anti-VLA4, 1.07 ± 0.07, p<0.01), suggesting that a crucial role of the VLA4 in inducing survival of cardiomyocytes by CM. sVCAM-1 and CM induced phosphorylation of FAK, Akt, Erk and p38 MAPK in neonatal rat cardiomyocytes. When pretreated with wortmannin, SB203580 and PD98059, the cardioprotective effects of sVCAM-1 and CM significantly inhibited, suggesting that sVCAM-1 might protect cardiomyocytes from oxidative stress via integrated upregulation of Akt, Erk and p38MAPK. These findings suggest cardiac progenitor cells promote angiogenesis and cardioprotection through their secreted sVCAM-1.
Pilot's Associate: a cooperative, knowledge-based system application (1991)

The Pilot's Associate program, a joint effort of the Defense Advanced Research Projects Agency (DARPA) and the US Air Force to build a cooperative, knowledge-based system to help pilots make decisions is described, and the lessons learned are examined. The Pilot's Associate concept developed as a set of cooperating, knowledge-based subsystems: two assessor and two planning subsystems, and a pilot interface. The two assessors, situation assessment and system status, determine the state of the outside world and the aircraft systems, respectively. The two planners, tactics planner and mission planner, react to the dynamic environment by responding to immediate threats and their effects on the prebriefed mission plan. The pilot-vehicle interface subsystem provides the critical connection between the pilot and the rest of the system. The focus is on the air-to-air subsystems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Survey of Logging Uses (1994)

Logging is ubiquitous in fault-tolerant systems and its use is growing in recent research. Logs are used for many purposes: keeping histories, security, concurrency control, failure recovery, update atomicity, fast physical writes, etc. This paper surveys the uses of logging and points out the commonalities and differences of clients&apos; needs. It aims to provide the user and the designer of a log system with a global vision of logging. Key words and phrases: Logging, record, audit, undo, redo, transaction, recovery, atomicity, write speed, debugging, garbage collection.
Insights into digestion and absorption of major nutrients in humans (2010)

Nutrient digestion and absorption is necessary for the survival of living organisms and has evolved into the complex and specific task of the gastrointestinal (GI) system. While most people simply assume that their GI tract will work properly to use nutrients, provide energy, and release wastes, few nonscientists know the details about how various nutrients are digested and how the breakdown products traverse the cells lining the small intestine to reach the blood stream and to be used by the other cells of the body. There have been several recent discoveries of new transporters that likely contribute to the absorption of oligopeptides and fatty acids. In addition, details are being clarified about how transporters work and in what forms nutrients can be absorbed. The enzymes that digest basic carbohydrates, proteins, and fats have been identified in various segments of the GI tract, and details are becoming clearer about what types of bonds they hydrolyze. Usually, detailed information about the digestion of basic nutrients is presented and learned in biochemistry courses and detailed information about absorption via transepithelial transport of the breakdown products of digestion is studied in physiology courses. The goal of this Staying Current article is to combine the details of the biochemistry of digestion with the updated information about the physiology of nutrient absorption into one source for teachers of physiology. Insights are included about some of the diseases and conditions that can bring about malabsorption of food in the GI tract and their consequences.
Design of Silica Encapsulated High-Q Photonic Crystal Nanobeam Cavity (2014)

We report on the design of photonic crystal nanobeam cavity fully encapsulated in silica. The proposed design, based on the principle of gentle confinement of the electromagnetic field, is mostly analytical and emphasizes on the most realistic options for fabricating nanocavities, in particular in III-V semiconductor materials. After determining the field decay inside the photonic bandgap of a nanobeam photonic crystal, we engineer the envelope of the cavity mode into a Gaussian shape by shifting only progressively the lattice constant. We discuss the various implementations of such shifts and give a simple algorithm to position each hole. The resonant wavelengths are found to depend linearly on the central lattice constant and on the radius of the holes. High Q factors above 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> and modal volume V close to ( λ/n) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> are obtained. In particular, Q factors remain high for a wide range of values of the central lattice constant and of holes radii, hence showing exceptional tunability properties as well as robustness with respect to common fabrication defects.
COLD-IN-PLACE RECYCLING: PERFORMANCE AND PRACTICES (1997)

Cold-In-Place Recycling (CIR) for road rehabilitation was introduced in eastern Canada in 1989. More than 5 million square meters (53 million square feet) of pavement have been rehabilitated with this process since 1989 throughout eastern Canada. CIR is a cost-effective rehabilitation alternative to traditional methods for aged cracked pavements in a cold and wet environment. This paper presents: a brief overview of CIR; project selection and design practices; the process equipment and construction procedures; and the performance of recycled bituminous mixtures.
Human Herpesvirus 8 Envelope Glycoprotein B Mediates Cell Adhesion via Its RGD Sequence (2003)

Human herpesvirus 8 (HHV-8) or Kaposi's sarcoma-associated herpesvirus, implicated in the pathogenesis of Kaposi's sarcoma, utilizes heparan sulfate-like molecules to bind the target cells via its envelope-associated glycoproteins gB and gpK8.1A. HHV-8-gB possesses the Arg-Gly-Asp (RGD) motif, the minimal peptide region of many proteins known to interact with subsets of host cell surface integrins. HHV-8 utilizes alpha3beta1 integrin as one of the receptors for its entry into the target cells via its gB interaction and induces the activation of focal adhesion kinase (FAK) (S. M. Akula, N. P. Pramod, F.-Z. Wang, and B. Chandran, Cell 108:407-419, 2002). Since FAK activation is the first step in the outside-in signaling necessary for integrin-mediated cytoskeletal rearrangements, cell adhesions, motility, and proliferation, the ability of HHV-8-gB to mediate the target cell adhesion was examined. A truncated form of gB without the transmembrane and carboxyl domains (gBdeltaTM) and a gBdeltaTM mutant (gBdeltaTM-RGA) with a single amino acid mutation (RGD to RGA) were expressed in a baculovirus system and purified. Radiolabeled HHV-8-gBdeltaTM, gBdeltaTM-RGA, and deltaTMgpK8.1A proteins bound to the human foreskin fibroblasts (HFFs), human dermal microvascular endothelial (HMVEC-d) cells, human B (BJAB) cells, and Chinese hamster ovary (CHO-K1) cells with equal efficiency, which was blocked by preincubation of proteins with soluble heparin. Maxisorp plate-bound gBdeltaTM protein induced the adhesion of HFFs and HMVEC-d and monkey kidney epithelial (CV-1) cells in a dose-dependent manner. In contrast, the gBdeltaTM-RGA and DeltaTMgpK8.1A proteins did not mediate adhesion. Adhesion mediated by gBdeltaTM was blocked by the preincubation of target cells with RGD-containing peptides or by the preincubation of plate-bound gBdeltaTM protein with rabbit antibodies against gB peptide containing the RGD sequence. In contrast, adhesion was not blocked by the preincubation of plate-bound gBdeltaTM protein with heparin, suggesting that the adhesion is mediated by the RGD amino acids of gB, which is independent of the heparin-binding domain of gB. Integrin-ligand interaction is dependent on divalent cations. Adhesion induced by the gBdeltaTM was blocked by EDTA, thus suggesting the role of integrins in the observed adhesions. Focal adhesion components such as FAK and paxillin were activated by the binding of gBdeltaTM protein to the target cells but not by gBdeltaTM-RGA protein binding. Inhibition of FAK phosphorylation by genistein blocked gBdeltaTM-induced FAK activation and cell adhesion. These findings suggest that HHV-8-gB could mediate cell adhesion via its RGD motif interaction with the cell surface integrin molecules and indicate the induction of cellular signaling pathways, which may play roles in the infection of target cells and in Kaposi's sarcoma pathogenesis.
Leptin attenuates respiratory complications associated with the obese phenotype (1998)

A profile of respiratory complications has been associated with the onset and development of obesity in humans. Similar phenotypes have been routinely demonstrated in genetic animal models of obesity such as the ob mouse (C57BL/6J-Lepob). The objective of the present study was to test the hypothesis that a constellation of respiratory complications are attenuated with leptin (i.e., protein product of the ob gene) replacement. Daily leptin administration during a 6-wk period was conducted to control body weight of mutant ob mice similar to genotypic control groups. During the treatment period, repeated baseline ventilatory measurements were assessed by using whole body plethysmography while quasistatic pressure-volume curves were performed to further explore the role of leptin in improving lung mechanics. Diaphragmatic myosin heavy chain (MHC) isoform phenotype was examined to determine proportional changes in MHC composition. In room air, breathing frequency and minute ventilation were significantly (P < 0.01) different among ob treatment groups, suggesting that leptin opposed the development of a rapid breathing pattern observed in vehicle-treated ob mice. Quasistatic deflation curves indicated that the lung volume of leptin-treated ob mice was significantly (P < 0.05) greater relative to vehicle-treated ob mice at airway pressures between 0 and 30 cmH2O. Diaphragm MHC composition of leptin-treated ob mice was restored significantly (P < 0.05) to resemble the control phenotype. In this genetic mouse model of obesity, the results suggested that respiratory complications associated with the obese phenotype, including rapid breathing pattern at baseline, diminished lung compliance, and abnormal respiratory muscle adaptations, are attenuated with prolonged leptin treatment.
Exploration on the Development of Green Eco-cultural Tourism in Sucrose Industry (2022)

As an important sugarcane producing area in China, sugarcane culture has become an important part of China's traditional culture. Taking Laibin area of Guangxi as an example, this paper discusses the environmental advantages suitable for sugarcane production, powerful socio-economic conditions and local unique sugarcane culture in Laibin area, Integrate the research perspective of local eco-cultural tourism development. By strengthening the construction of local infrastructure in Laibin area, integrating tourism, sugarcane and cultural resources, promote the vigorous development of eco-cultural tourism experience projects dominated by local sugarcane culture, promote economic income and realize local industrial upgrading.
Inhibition of the PI3K Pathway: Hope We Can Believe in? (2010)

The phosphoinositide 3-kinase (PI3K) pathway is one of the most commonly activated pathways in human cancer and has roles in cell proliferation, apoptosis, protein synthesis, and metabolism. The PI3K pathway can be activated by amplification or activating mutation of upstream receptor tyrosine kinases, and by mutations or deletions downstream in the pathway. Trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER2), has been one of the most successful and most widely used targeted therapies. However, many HER2-positive cancers are not sensitive to HER2-based therapies or become resistant during treatment; downstream activation of the pathway is one of the causes of resistance. Because of the common activation of the PI3K pathway in cancer, compounds targeting proteins downstream in the pathway have been developed in recent years. The mammalian target of rapamycin (mTOR) inhibitors everolimus and temsirolimus have been shown to be beneficial in certain cancer types; many other inhibitors of the PI3K pathway are in various stages of clinical development. Ongoing research should clarify which molecular cancer subtypes are most susceptible to specific compounds and explore combinatorial approaches, ultimately leading to individualized patient treatment.
Perceptions and Major Challenges of Women Leaders in the Lowest Level Local Government in Bangladesh: Unheard Voices and Realities from the Grassroots (2014)

This paper is about perceptions and challenges of the women leaders (WLs) in the grassroots based local government in Bangladesh, i.e. Union Parishad (UP). Local government of Bangladesh has a history of 144 years but women’s representation is ensured just only 2 decades ago. Within the span of 2 decades, WLs are yet to ensure their effective participation and still they are to struggle a lot due to some built-in problems of the UP. Against such a context, the paper is aimed at unraveling the research questions: i) How women leaders perceived their roles and participation in the UP affairs? ii) Do they face challenges in ensuring their perceived roles and responsibil ities in the UP and if so, what are those challenges? and to fulfill research objectives: i) To tap perceptions of the WLs in identifying their roles and responsibilities in the UP affairs; ii) To identify the major challenges of the WLs encountered in ensuring their role and participation in the UP. The paper is based on phenomenological approach which was supported by FGDs, case study, content analysis and observation methods. The findings of the paper reveal that women leaders have internalized their role and participation rightly in the UP. The WLs perceived participation as taking part in areas of important decision-making and upholding their voices and choices for the interest of their constituents. The WLs identified major challenges towards playing their role and participation in the UP such as i) patriarchy or male domination, ii) corruption and iii) faulty legal provision imposed upon them. All these problems are in general governance problems of Bangladesh society. Solution might be changing the legal and structural arrangements in the UP. More affirmative action such as education facilities should be expanded in the society to enhance women’s participation and to modify value system as traditional values help perpetuate patriarchy and other social ills.
Battery Storage System for Frequency Stabilization of AC Networks with High Penetration of Renewable Power (2013)

This paper investigates the uses of battery energy storage system (BESS) in ac networks highly populated with wind power generation. The investigation includes power system load leveling, frequency stabilization, and provision of reactive power supp ort to the wind farm network. The BESS is connected to the wind farm main hub via voltage source converter, while the wind farm is connected to ac network modele d with detailed synchronous generator, including exci tation and turbine-governor control. In general the paper attempted to study the role of BESS in modern power system regarding improving system stability. Time- domain simulations conducted in Matlab/Simulink are used to validate the importance of the BESS.
Carrier generation using a dual-frequency distributed feedback waveguide laser for phased array antenna (PAA) (2017)

Carrier generation based on optical heterodyning techniques where a beat signal is generated from the mixing of two light sources can be interesting solution due to ease on tunability. The free running heterodyning scheme benefits with a very wide tuning capability and the generated carrier can be freely adjusted. However, the drawbacks come in the form of frequency stability. Heterodyning of two optical frequencies coming from a single laser cavity has shown its potential on improvement of frequency stability. The impact of the laser parameters (i.e., optical power and linewidth) on the quality of the generated carrier (i.e., phase/frequency stability and carrier-to-noise ratio) is analyzed for a 25×64 elements PAA system. An optically generated carrier signal using a dual-frequency distributed feedback waveguide laser in ytterbium doped aluminum oxide (Al2O3:Yb3+) is analyzed and experimentally demonstrated in this paper. The carrier signal is used for downconversion of the signal received from a phased array antenna (PAA) of a DVB-S (Digital Video Broadcasting-Satellite) system. An optical frequency locked loop (OFLL) to stabilize the generated carrier is implemented which results in a microwave frequency at ∼14 GHz with a phase noise of -75 dBc/Hz at 1 MHz offset from the center frequency and gives a loop settling time of 12 μs. By using the proposed OFLL, the long term and the short term frequency stability of the generated carrier has an Allan deviation of more than 1×10−10 for an averaging time of 1000 s and a standard deviation of 39.4 kHz, respectively. The lasers linewidth should be in the order of tens of Hz, with a maximum relative intensity noise (RIN) of -107 dB/Hz and a minimum optical power of 0.94 mW. The optical carrier generation by OFLL using a DFL to comply with the requirements of the standard carrier used in commercial LNBs has been investigated. The detailed analysis of the OFLL scheme is presented. Specifications requirement on carrier power, linewidth and relative intensity noise of the optically generated carrier have been addressed. The optical carrier generation is experimentally demonstrated and the requirements on CNR have been determined by measuring the noise floor and the optical carrier power. The measured values are compared with the calculated values and found to be very close.
Toll-like receptor (TLR) polymorphisms in African children: Common<i>TLR-4</i>variants predispose to severe malaria (2005)

Genetic host factors play a substantial role in susceptibility to and severity of malaria, which continues to cause at least one million deaths per year. Recently, members of the toll-like receptor (TLR) family have been shown to be involved in recognition of the etiologic organism Plasmodium falciparum: The glycosylphosphatidylinositol anchor induces signaling in host cells via TLR-2 and -4, whereas hemozoin-induced immune activation involves TLR-9. Binding of microbial ligands to the respective TLRs triggers the release of proinflammatory cytokines via the TLR/IL-1 receptor (TIR) domain and may contribute to the host response in malaria, including cytokine induction and fever. In a case-control study among 870 Ghanaian children, we examined the influence of TLR-2, -4, and -9 polymorphisms in susceptibility to severe malaria. TLR-2 variants common in Caucasians and Asians were completely absent. However, we found a rare previously undescribed mutation (Leu658Pro), which impairs signaling via TLR-2. We failed to detect any polymorphisms within the TLR-9 Toll/IL-1 receptor domain. Two frequent TLR-9 promoter polymorphisms did not show a clear association with malaria severity. In contrast, the TLR-4-Asp299Gly variant occurred at a high rate of 17.6% in healthy controls and was even more frequent in severe malaria patients (24.1%, P < 0.05). Likewise, TLR-4-Thr399Ile was seen in 2.4% of healthy children and in 6.2% of patients (P = 0.02). TLR-4-Asp299Gly and TLR-4-Thr399Ile conferred 1.5- and 2.6-fold increased risks of severe malaria, respectively. These findings suggest TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms to be associated with disease manifestation.
Ultracomputers (1980)

A class of parallel processors potentially involving thousands of individual processing elements is described. The architecture is based on the perfect shuffle connection and has two favorable characteristics: (1) Each processor communicates with a fixed number of other processors. (2) Important communication functions can be accomplished in time proportional to the logarithm of the number of processors. A number of basic algorithms for these “ultracomputers” are presented, and physical design considerations are discussed in a preliminary fashion.
Anti‐gravity treadmills are effective in reducing knee forces (2012)

Lower body positive pressure (LBPP) treadmills permit significant unweighting of patients and have the potential to enhance recovery following lower limb surgery. We determined the efficacy of an LBPP treadmill in reducing knee forces in vivo. Subjects, implanted with custom electronic tibial prostheses to measure forces in the knee, were tested on a treadmill housed within a LBPP chamber. Tibiofemoral forces were monitored at treadmill speeds from 1.5 mph (0.67 m/s) to 4.5 mph (2.01 m/s), treadmill incline from -10° to +10°, and four treadmill chamber pressure settings adjusted to decrease net treadmill reaction force from 100% to 25% of the subject's body weight (BW). The peak axial tibiofemoral force ranged from 5.1 times BW at a treadmill speed of 4.5 mph (2.01 m/s) and a pressure setting of 100% BW to 0.8 times BW at 1.5 mph (0.67 m/s) and a pressure setting of 25% BW. Peak knee forces were significantly correlated with walking speed and treadmill reaction force (R(2) = 0.77, p = 0.04). The LBPP treadmill might be an effective tool in the rehabilitation of patients following lower-extremity surgery. The strong correlation between tibiofemoral force and walking speed and treadmill reaction forces allows for more precisely achieving the target knee forces desired during early rehabilitation.