gebhart/patrepeval huggingface dataset:
Photochemical Conversion of Solar Energy (2007)

Energy is the most important issue of the 21st century. About 85% of our energy comes from fossil fuels, a finite resource unevenly distributed beneath the Earth's surface. Reserves of fossil fuels are progressively decreasing, and their continued use produces harmful effects such as pollution that threatens human health and greenhouse gases associated with global warming. Prompt global action to solve the energy crisis is therefore needed. To pursue such an action, we are urged to save energy and to use energy in more efficient ways, but we are also forced to find alternative energy sources, the most convenient of which is solar energy for several reasons. The sun continuously provides the Earth with a huge amount of energy, fairly distributed all over the world. Its enormous potential as a clean, abundant, and economical energy source, however, cannot be exploited unless it is converted into useful forms of energy. This Review starts with a brief description of the mechanism at the basis of the natural photosynthesis and, then, reports the results obtained so far in the field of photochemical conversion of solar energy. The "grand challenge" for chemists is to find a convenient means for artificial conversion of solar energy into fuels. If chemists succeed to create an artificial photosynthetic process, "... life and civilization will continue as long as the sun shines!", as the Italian scientist Giacomo Ciamician forecast almost one hundred years ago.
Antiparallel β‐Sheet Conformation in Cyclopeptides Containing a Pseudo‐amino Acid with a biphenyl moiety (1994)

Abstract The biphenyl‐containing pseudo‐amino acids 2′‐(aminomethyl)biphenyl‐2‐carboxylic acid (Abc; 1 ) and 2′‐(aminomethyl)biphenyl‐2‐acetic acid (Aba; 2 ) are used as rigid spacers in the backbone of the cyclic peptides cyclo (‐Abc‐Ala‐Phe‐Gly‐) 2 ( 5 ), cyclo(‐Abc‐Ala‐Val‐Gly‐) 2 ( 6 ), cyclo(‐Aba‐Gly‐Phe‐Ala‐) 2 ( 7 ), and cyclo(‐Aba‐Ala‐Phe‐Gly‐) 2 ( 8 ). Three different interconverting diastereoisomers are found in solutions of each of these cyclopeptides due to the atropisomerism of the biphenyl units. NMR Techniques and molecular‐dynamics calculations allow to conclude that the major diastereoisomer of 5 (and 6 ) in (D 6 )DMSO adopts a β‐sheet conformation. It is proposed that the pseudo‐amino acid 1 of ( R )‐chirality forms, with attached L ‐amino acids, a H‐bonding pattern comparable to a β‐turn (see D in Fig. 4 and F ).
1-Bit compressive sensing (2008)

Compressive sensing is a new signal acquisition technology with the potential to reduce the number of measurements required to acquire signals that are sparse or compressible in some basis. Rather than uniformly sampling the signal, compressive sensing computes inner products with a randomized dictionary of test functions. The signal is then recovered by a convex optimization that ensures the recovered signal is both consistent with the measurements and sparse. Compressive sensing reconstruction has been shown to be robust to multi-level quantization of the measurements, in which the reconstruction algorithm is modified to recover a sparse signal consistent to the quantization measurements. In this paper we consider the limiting case of 1-bit measurements, which preserve only the sign information of the random measurements. Although it is possible to reconstruct using the classical compressive sensing approach by treating the 1-bit measurements as plusmn 1 measurement values, in this paper we reformulate the problem by treating the 1-bit measurements as sign constraints and further constraining the optimization to recover a signal on the unit sphere. Thus the sparse signal is recovered within a scaling factor. We demonstrate that this approach performs significantly better compared to the classical compressive sensing reconstruction methods, even as the signal becomes less sparse and as the number of measurements increases.
Matching Criteria for Vocabulary-Independent Search (2012)

This paper investigates a variety of progressively more complex similarity measures for vocabulary independent search in phone based audio transcripts. English audio data is segmented and decoded to produce a sequence of phones that represent the data. These sequences are then parsed into <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> -grams which are used to index the data. The audio segments define the documents to be retrieved and are thus localized in time. Search is performed by expanding text based queries into phone sequences and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> -grams, followed by matching these against the index. The baseline similarity measure combines elements found in the literature and uses edit distance with a phonetic confusion matrix to determine the similarity of query and index <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> -grams. Comparable performance to other approaches in the literature is achieved. Extensions to the baseline are developed using a constrained form of the similarity measure together with the ability to account for higher order confusions, namely of phone bi-grams and tri-grams. Results show improved performance across a variety of system configurations. We then generalize further and use the framework of conditional random fields (CRFs) to model confusions. Whereas others in the literature have used CRFs to model parameters of an edit distance that incorporates deletions, substitutions, and insertions, our approach focuses on using CRFs to model context dependent phone level confusions directly. The CRF is trained on parallel phonetic transcripts, which provides a general framework for modeling the errors that a recognition system may make, taking contextual effects into consideration. Results obtained on both in and out of vocabulary (OOV) search tasks improve most notably for OOV, showing 5%-6% relative improvement. Finally, we investigate the degree to which the information captured in the three approaches is complementary and show that system combination can further improve performance.
Selective VEGFR Inhibitors for Anticancer Therapeutics in Clinical Use and Clinical Trials (2012)

Angiogenesis and vasculogenesis, regulated by VEGF/VEGFR signaling pathways, play key roles in tumor growth and metastasis. Selective inhibition of VEGFR kinase has been explored as a highly successful clinical strategy in cancer treatment. A number of VEGFR inhibitors have been approved in clinical use and many more are in various stages of drug development. This paper reviews selective small-molecule VEGFR inhibitors in clinical uses and in clinical trials, with particular focus on in vitro, in vivo and clinical trial results of these inhibitors. The VEGF/VEGFR genes and signaling pathways involved in tumor angiogenesis, and the strategies for accessing and improving the therapeutic efficacy of VEGFR inhibitors are also discussed.
One-Step Detection of Galectins on Hybrid Monolayer Surface with Protruding Lactoside (2010)

Galectins, or beta-galactoside binding lectins, are detected deep in tumor tissue and are recognized as diagnostic and prognostic markers of cancer and other serious diseases. There is a need to develop a faster, easier, and simpler method for detecting galectins. We have succeeded in forming a mixed self-assembled monolayer (SAM) interface consisting of beta-galactoside terminated alkanethiol (lactoside protuberant dodecanethiol) and tri(ethylene glycol) (TEG) terminated short alkanethiol, which proved to be a superior protein resistant material, to enable us to develop a label-free, one-step, and highly sensitive system for detecting the expected biomarker, galectin. We successfully detected nanomolar level (~ 1 nM) galectin-4 and -8 on a 4% lactoside protrusive surface, even though the affinity between the galectins and lactoside was very weak (KD = 1 x 10(-3)~1 x 10(-6)). The combination of the suppression of background noise by filling with TEG terminated short alkanethiol and control of the ligand ratio in the interface contributed to the highly sensitive detection of galectin. We also detected galectin-4 at subten nanomolar levels even in a solution containing much higher concentrations of serum proteins (1800 times larger than the galectin concentration) without using molecule labeling or an immunological method.
Hybrid-Bridge-Based DAB Converter With Voltage Match Control for Wide Voltage Conversion Gain Application (2017)

This paper proposes a voltage match (VM) control for hybrid-bridge-based dual active bridge (DAB) converter in wide voltage conversion gain applications. With the addition of an auxiliary half-bridge circuit, the topology becomes an integration of a half-bridge and a full-bridge DAB converter. Unlike other pulse width modulation generation method for DAB converters, this converter utilizes four-level voltage at one port of the transformer to obtain matched voltage waveforms within the range of twice the minimum conversion gain. Wide conversion gain, decoupling of the two power control variables and wide zero-voltage switching (ZVS) ranges can be achieved with the proposed VM control. Full load ranges of ZVS for the six main power switches can be achieved and the two auxiliary switches can also operate in a wide ZVS range. In addition, the power control is done only using two control variables and its implementation is very simple, only needing a divider and a conventional voltage regulator. These characteristics and benefits of the proposed control are verified by experimental results from a 1-kw converter prototype.
Current knowledge on exosome biogenesis and release (2017)

Exosomes are nanosized membrane vesicles released by fusion of an organelle of the endocytic pathway, the multivesicular body, with the plasma membrane. This process was discovered more than 30 years ago, and during these years, exosomes have gone from being considered as cellular waste disposal to mediate a novel mechanism of cell-to-cell communication. The exponential interest in exosomes experienced during recent years is due to their important roles in health and disease and to their potential clinical application in therapy and diagnosis. However, important aspects of the biology of exosomes remain unknown. To explore the use of exosomes in the clinic, it is essential that the basic molecular mechanisms behind the transport and function of these vesicles are better understood. We have here summarized what is presently known about how exosomes are formed and released by cells. Moreover, other cellular processes related to exosome biogenesis and release, such as autophagy and lysosomal exocytosis are presented. Finally, methodological aspects related to exosome release studies are discussed.
Tree-Based RFID Yoking Proof (2009)

RFID (radio frequency identification) yoking proof protocol allows a verifier to collect the proof of the simultaneous presence of two tags in the communication range of a specified reader. This proof has found several interesting applications. However, in the existing RFID yoking schemes, the computational cost of identifying a tag in the back-end server is O(N), where N is the number of tags. This paper proposes a tree-based yoking-proof scheme, which employs the tree structure to organize the tags and treats the dynamically updated paths of tags as the secrets to identify the tags. This arrangement results in great improvement of only O(1) computational cost to identifying the tag.
An Equilibrium Approach to the Aggregation of Beliefs (2013)

This paper presents a new answer to the old question of how to aggregate individual beliefs. We construct a model which allows agents to take arbitrage opportunities against the aggregated belief by making contingent claims against the states, and the aggregator (market maker) regulates the probability of states. When all claims from the agents are mutually covered for every realization of the state, an aggregation of individual beliefs is thus obtained. We prove the existence and uniqueness of the equilibrium aggregation, and also show that the aggregate belief lies in the convex hull of individual beliefs. This model allows us to address some important problems such as how individual agent¡¯s attitude toward risk and wealth endowment affect the outcome of the aggregation process, and whether the aggregate belief satisfies the well-known properties like equal treatment.
Active site directed N-carboxymethyl peptide inhibitors of a soluble metalloendopeptidase from rat brain (1984)

A soluble metalloendopeptidase isolated from rat brain preferentially cleaves bonds in peptides having aromatic residues in the P1 and P2 position. An additional aromatic residue in the P3' position greatly increases the binding affinity of the substrate, suggesting the presence of an extended substrate recognition site in the enzyme, capable of binding a minimum of five amino acid residues [Orlowski, M., Michaud, C., & Chu, T.G. (1983) Eur. J. Biochem. 135, 81-88]. A series of N-carboxymethyl peptide derivatives structurally related to model substrates and containing a carboxylate group capable of coordinating with the active site zinc atom were synthesized and tested as potential inhibitors. One of these inhibitors, N-[1(RS)-carboxy-2-phenylethyl]-Ala-Ala-Phe-p-aminobenzoate, was found to be a potent competitive inhibitor of the enzyme with a Ki of 1.94 microM. The two diastereomers of this inhibitor were separated by high-pressure liquid chromatography. The more potent diastereomer had a Ki of 0.81 microM. The inhibitory potency of the less active diastereomer was lower by 1 order of magnitude. Decreasing the hydrophobicity of the residue binding the S1 subsite of the enzyme by, for example, replacement of the phenylethyl group with a methyl residue decreased the inhibitory potency by almost 2 orders of magnitude. Deletion of the carboxylate group decreased the inhibitory potency by more than 3 orders of magnitude. Shortening the inhibitor chain by a single alanine residue had a similar effect. Binding of the inhibitor to the enzyme increased its thermal stability.(ABSTRACT TRUNCATED AT 250 WORDS)
Long-term nocturnal calcium infusions can cure rickets and promote normal mineralization in hereditary resistance to 1,25-dihydroxyvitamin D. (1986)

We report the beneficial effects of calcium infusions in a child with hereditary resistance to 1,25(OH)2D and alopecia. This patient after transient responsiveness to vitamin D derivatives became unresponsive to all therapy despite serum 1,25(OH)2D concentrations maintained at levels approximately 100-fold normal. A 7-mo trial with calcium infusions led to correction of biochemical abnormalities and healing of rickets. Bone biopsies (n = 3) showed a normal mineralization and the disappearance of the osteomalacia. Cultures of bone-derived cells demonstrated a lack of activation of 25-hydroxyvitamin D 24-hydroxylase and osteocalcin synthesis by 1,25(OH)2D3 (10(-9) and 10(-6) M). These results demonstrate that even in the absence of a normal 1,25(OH)2D3 receptor-effector system in bone cells, normal mineralization can be achieved in humans if adequate serum calcium and phosphorus concentrations are maintained; and calcium infusions may be an efficient alternative for the management of patients with this condition who are unresponsive to large doses of vitamin D derivatives.
Enterprise security: legal challenges and possible solutions (2002)

To survive in business, especially the online world, an enterprise requires an effective security infrastructure. However, enterprises should bear in mind that there is often also a legal obligation to keep certain data or information secure, emanating from legislation such as intellectual property, data protection or trade secret legislation or from contract. A number of technological measures already exist to provide security in the online world, such as encryption, electronic signatures and privacy enhancing technologies. However, one often encounters a number of legal constraints to the use of these measures through, for example, restrictions on the export and use of cryptography, difficulties and doubts of the legal recognition of electronic signatures, and different national rules on certification services. If electronic commerce is to grow, there is need for more international cooperation as well as mutual recognition of, and more liberalisation of, such regulations. The paper discusses the legal obligation of enterprise security and considers mechanisms to ensure security.
GABA<sub>A</sub> receptor transmembrane amino acids are critical for alcohol action: disulfide cross‐linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites (2013)

Alcohols and inhaled anesthetics modulate GABA(A) receptor (GABA(A)R) function via putative binding sites within the transmembrane regions. The relative position of the amino acids lining these sites could be either inter- or intra-subunit. We introduced cysteines in relevant TM locations and tested the proximity of cysteine pairs using oxidizing and reducing agents to induce or break disulfide bridges between cysteines, and thus change GABA-mediated currents in wild-type and mutant α1β2γ2 GABA(A)Rs expressed in Xenopus laevis oocytes. We tested for: (i) inter-subunit cross-linking: a cysteine located in α1TM1 [either α1(Q229C) or α1(L232C)] was paired with a cysteine in different positions of β2TM2 and TM3; (ii) intra-subunit cross-linking: a cysteine located either in β2TM1 [β2(T225C)] or in TM2 [β2(N265C)] was paired with a cysteine in different locations along β2TM3. Three inter-subunit cysteine pairs and four intra-subunits cross-linked. In three intra-subunit cysteine combinations, the alcohol effect was reduced by oxidizing agents, suggesting intra-subunit alcohol binding. We conclude that the structure of the alcohol binding site changes during activation and that potentiation or inhibition by binding at inter- or intra-subunit sites is determined by the specific receptor and ligand.
Flexible threshold voltage FinFETs with independent double gates and an ideal rectangular cross-section Si-Fin channel (2004)

The FT-FinFETs with independent double gates and an ideal rectangular cross-section Si-Fin channel have successfully been fabricated by using newly developed orientation-dependent wet etching. The flexible V/sub th/ controllability by using one of the double gates as a control gate and by the synchronized driving mode operation is experimentally confirmed. The developed processes are attractive for the fabrication of the advanced separate-gates FinFET for a flexible function VLSI circuit.
Bone Marrow‐Derived Cells Present MHC Class I‐Restricted Tumour Antigens in Priming of Antitumour Immune Responses (2007)

Many tumours express tumour-specific antigens capable of being presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules. Current models of antigen presentation predict that the tumour cell itself should present its own MHC class I-restricted antigens to T cells. Earlier cross-priming experiments have demonstrated that at least some MHC class I-restricted antigens may also be presented by bystander cells. There is no detectable presentation of MHC class I-restricted tumour antigens by the tumour itself during priming of tumour-specific responses. The tumour antigens are presented exclusively by host bone marrow-derived cells. These results imply that an efficient mechanism exists in vivo for transfer of MHC I-restricted antigens to bone marrow-derived antigen presenting cells. They also suggest that HLA matching may not be critical in the clinical application of allogeneic tumour vaccines.
Dual-element induction cooking unit using power MOSFETs (1985)

This paper describes a dual-element induction cooking unit using power MOSFETs. The circuit is based on a single-ended push-pull design which enables individual full-range power control of two induction cooking elements from one inverter power supply. Throughout the work provision is made for the inclusion of individual-element automatic power level circuitry.
Applications of a Nonlinear Organic Reaction of Carbamates To Proliferate Aliphatic Amines (2000)

Base amplifiers such as the carbamate compounds 1 generate more bases than they consume. The base-catalyzed fragmentation reaction of 1 liberates the corresponding aliphatic amines which catalyze the decomposition of the carbamates (see scheme). This leads to autocatalytic, nonlinear fragmentation of 1, in a novel nonlinear organic reaction. The addition of the base amplifier to an epoxy polymer sensitized with a photobase generator results in the marked improvement of sensitivity.
Food Safety Traceability System Based on Blockchain and EPCIS (2019)

In recent years, food safety issues have drawn growing concerns from society. In order to efficiently detect and prevent food safety problems and trace the accountability, building a reliable traceability system is indispensable. It is especially essential to accurately record, share, and trace the specific data within the whole food supply chain, including the process of production, processing, warehousing, transportation, and retail. The traditional traceability systems have issues, such as data invisibility, tampering, and sensitive information disclosure. The blockchain is a promising technology for the food safety traceability system because of the characteristics, such as the irreversible time vector, smart contract, and consensus algorithm. This paper proposes a food safety traceability system based on the blockchain and the EPC Information Services and develops a prototype system. The management architecture of on-chain & off-chain data is proposed as well, through which the traceability system can alleviate the data explosion issue of the blockchain for the Internet of Things. Furthermore, the enterprise-level smart contract is designed to prevent data tampering and sensitive information disclosure during information interaction among participants. The prototype system was implemented based on the Ethereum. According to the test results, the average time of information query response is around 2 ms, while the amount of on-chain data and query counts are 1 GB and 1000 times/s, respectively.
A double‐blind placebo‐controlled study of the efficacy and safety of pentoxifylline in early chronic Peyronie’s disease (2009)

PTX-R was moderately effective in reducing penile curvature and plaque volume in patients with early chronic PD. Further studies with different treatment regimens are needed to better elucidate the beneficial effects of PTX-SR in PD.
Emerging medical therapies for severe alcoholic hepatitis (2020)

Severe alcoholic hepatitis (AH) is an acute and often devastating form of alcohol-associated liver disease. Clinically, AH is characterized by elevated bilirubin, model for end stage liver disease scores >20, and nonspecific symptoms that are caused by underlying inflammation, hepatocyte injury, and impaired intestinal barrier function. Compromised immune defense in AH contributes to infections, sepsis and organ failure. To date, corticosteroids are the only recommended treatment for severe AH, however it does not provide survival benefits beyond 1 month. Recent preclinical and early clinical studies in AH aided understanding of the disease and presented opportunities for new therapeutic options targeting inflammation, oxidative stress, liver regeneration and modification of intestinal microbiota. In this comprehensive review, we discuss promising preclinical results and ongoing clinical trials evaluating novel therapeutic agents for the treatment of severe AH.