gebhart/patrepeval huggingface dataset:
Quantitative<i>in vivo</i>assessment of lung microstructure at the alveolar level with hyperpolarized<sup>3</sup>He diffusion MRI (2002)

The study of lung emphysema dates back to the beginning of the 17th century. Nevertheless, a number of important questions remain unanswered because a quantitative localized characterization of emphysema requires knowledge of lung structure at the alveolar level in the intact living lung. This information is not available from traditional imaging modalities and pulmonary function tests. Herein, we report the first in vivo measurements of lung geometrical parameters at the alveolar level obtained with 3He diffusion MRI in healthy human subjects and patients with severe emphysema. We also provide the first experimental data demonstrating that 3He gas diffusivity in the acinus of human lung is highly anisotropic. A theory of anisotropic diffusion is presented. Our results clearly demonstrate substantial differences between healthy and emphysematous lung at the acinar level and may provide new insights into emphysema progression. The technique offers promise as a clinical tool for early diagnosis of emphysema.
Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp<sup>3</sup>–sp<sup>2</sup> Suzuki Coupling of a Benzyl Carbonate (2018)

Process development for the synthesis of a locally acting sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, LX2761, a drug candidate for the treatment of diabetes mellitus, is described. A convergent route based on a retrosynthetic disconnection of the central diarylmethane linkage to a benzyl carbonate and a hindered arylboronic ester was designed and developed. The syntheses of these fully elaborated, late-stage crystalline intermediates are discussed, along with optimization of their union via an sp3–sp2 Suzuki–Miyaura coupling reaction. The final active pharmaceutical ingredient was isolated in high purity as its l-proline cocrystal. This process was successfully performed on a kilogram scale to support toxicology and preclinical studies.
A contex-based predictive coder for lossless and near-lossless compression of video (2002)

We propose a new approach to context-based predictive coding of video, where the interframe or intraframe coding mode is adaptively selected on a pixel basis. We perform the coding mode selection using only the previously reconstructed samples which are also available at the decoder, so that any overhead information on the coding mode selection does not need to be transmitted to the decoder. The proposed coder also provides the lossless concatenated coding property when applied to multigeneration of video sequences since the same coding mode information is available at the second time encoding. The proposed coding mode selection enables the coder to easily incorporate error modeling and context modeling by performing the intraframe coding with one of the existing image coders such as the JPEG-LS standard. Experiments show that the proposed approach in conjunction with the JPEG-LS standard provides significant improvements in compression efficiency.
Unsupervised Indoor Localization (2012)

We propose UnLoc, an unsupervised indoor localization scheme that bypasses the need for war-driving. Our key observation is that certain locations in an indoor environment present identifiable signatures on one or more sensing dimensions. An elevator, for instance, imposes a distinct pattern on a smartphone’s accelerometer; a corridor-corner may overhear a unique set of WiFi access points; a specific spot may experience an unusual magnetic fluctuation. We hypothesize that these kind of signatures naturally exist in the environment, and can be envisioned as internal landmarks of a building. Mobile devices that “sense” these landmarks can recalibrate their locations, while dead-reckoning schemes can track them between landmarks. Results from 3 different indoor settings, including a shopping mall, demonstrate median location errors of 1.69m. War-driving is not necessary, neither are floorplans ‐ the system simultaneously computes the locations of users and landmarks, in a manner that they converge reasonably quickly. We believe this is an unconventional approach to indoor localization, holding promise for real-world deployment.
The Murine Homologues of the Huntington Disease Gene (Hdh) and the α-Adducin Gene (Add1) Map to Mouse Chromosome 5 within a Region of Conserved Synteny with Human Chromosome 4p16.3 (1994)

Huntington disease (HD) is a severe autosomal dominant neurodegenerative disorder associated with a novel gene (IT15). Recently, we reported the cloning of Hdh, the murine homologue of IT15. Here, using an interspecific backcross, we have mapped both Hdh and the mouse homologue of human alpha-adducin (Add1), a membrane-associated cytoskeletal protein gene. Both of these genes map in the same position on mouse chromosome 5 in a region associated with ancestral chromosomal rearrangements and show no recombination with D5H4S43, D5H4S115, and D5H4S62, the murine homologues of D4S43, D4S115, and D4S62, respectively. Further mapping studies of humans, mice, and other mammalian species should reveal the nature of the rearrangements affecting this chromosomal segment during mammalian evolution.
A burst-mode photon counting receiver with automatic channel estimation and bit rate detection (2016)

We demonstrate a multi-rate burst-mode photon-counting receiver for undersea communication at data rates up to 10.416 Mb/s over a 30-foot water channel. To the best of our knowledge, this is the first demonstration of burst-mode photon-counting communication. With added attenuation, the maximum link loss is 97.1 dB at λ=517 nm. In clear ocean water, this equates to link distances up to 148 meters. For λ=470 nm, the achievable link distance in clear ocean water is 450 meters. The receiver incorporates soft-decision forward error correction (FEC) based on a product code of an inner LDPC code and an outer BCH code. The FEC supports multiple code rates to achieve error-free performance. We have selected a burst-mode receiver architecture to provide robust performance with respect to unpredictable channel obstructions. The receiver is capable of on-the-fly data rate detection and adapts to changing levels of signal and background light. The receiver updates its phase alignment and channel estimates every 1.6 ms, allowing for rapid changes in water quality as well as motion between transmitter and receiver. We demonstrate on-the-fly rate detection, channel BER within 0.2 dB of theory across all data rates, and error-free performance within 1.82 dB of soft-decision capacity across all tested code rates. All signal processing is done in FPGAs and runs continuously in real time.
Treatment of anthracycline extravasation with dexrazoxane. (2000)

Accidental extravasation of anthracyclines is a feared complication. Present treatment consists of local cooling and extensive surgical debridement, which often results in severe morbidity. All clinically important anthracyclines are topoisomerase II poisons that are antagonized by topoisomerase II catalytic inhibitors such as dexrazoxane. Therefore, we investigated whether dexrazoxane protects against extravasation lesions caused by anthracyclines. B6D2F1 mice received s.c. daunorubicin, doxorubicin, or idarubicin followed by systemic treatment with dexrazoxane or saline. One single systemic dose of dexrazoxane immediately after s.c. administration of doxorubicin, daunorubicin, or idarubicin reduced the tissue lesions (expressed as area under the curve of wound size times duration) by 96% (P < 0.0001), 70% (P < 0.0001), and 87% (P = 0.0004), respectively. Moreover, the treatment resulted in a statistically significant reduction in the fraction of mice with wounds as well as the duration of wounds. The induction of wounds was dose-dependent, as was the degree of protection by dexrazoxane. Dexrazoxane could be administered up to 3 h after the anthracycline without loss of protection. Triple-dosage of dexrazoxane tended to be more effective than a single injection. Dexrazoxane had no effect on lesions induced by hydrogen peroxide. This is the first report of use of a topoisomerase II catalytic inhibitor such as dexrazoxane in the treatment of anthracycline extravasation injuries. These convincing preclinical data represent a novel nontoxic approach that can easily be implemented into the clinical handling of accidental extravasation of anthracyclines.
Capping of Immune Complexes by Sporozoites of Eimeria tenella (1985)

Sporozoites of Eimeria tenella were incubated for 10, 20, or 30 min with parasite-specific monoclonal IgG antibody 3D3II from mice and then rinsed in a Tris-buffered glucose saline solution (TBGS). Some sporozoites were then incubated for 10, 20, or 30 min with ferritin- or colloidal gold-conjugated goat anti-mouse IgG antibody and then fixed in 2.5% glutaraldehyde and prepared for transmission (TEM) or scanning (SEM) electron microscopy. Other sporozoites that had been previously exposed to monoclonal antibody were prefixed with 0.25% glutaraldehyde, incubated with ferritin- or colloidal gold-conjugated anti-mouse IgG antibody and then fixed and prepared for TEM or SEM. Control preparations consisted of sporozoites exposed only to TBGS, monoclonal antibody 3D3II or to ferritin- or colloidal gold-conjugated anti-mouse IgG antibody. Capping of immune complexes occurred only on the surface of those sporozoites exposed to monoclonal antibody 3D3II followed by ferritin- or gold-conjugated antibody. Immune complexes moved laterally and posteriorly on the outer surface of the parasite plasma membrane to form a cap at the posterior end of the sporozoite. Capping did not occur in TBGS controls nor in sporozoites treated with monoclonal antibody 3D3II and prefixed in 0.25% glutaraldehyde before exposure to ferritin- or gold-conjugated antibody. Thus, capping of surface antigens did not occur in the presence of monoclonal 3D3II antibody only, whereas specimens exposed to both monoclonal and ferritin- or colloidal gold-conjugated antibodies were able to cap immune complexes.
Use of random noise for on-line transducer modeling in an adaptive active attenuation system (1989)

Active sound attenuation systems may be described using a system identification framework in which an adaptive filter is used to model the performance of an unknown acoustical plant. An error signal may be obtained from a location following an acoustical summing junction where the undesired noise is combined with the output of a secondary sound source. For the model output to properly converge to a value that will minimize the error signal, it is frequently necessary to determine the transfer function of the secondary sound source and the path to the error signal measurement. Since these transfer functions are unknown and continuously changing in a real system, it is desirable to perform continuous on-line modeling of the output transducer and error path. In this article, the use of an auxiliary random noise generator for this modeling is described. Based on a Galois sequence, this technique is easy to implement, provides continuous on-line modeling, and has minimal effect on the final value of the error signal.
Affinity purification of fibrinogen using a ligand from a peptide library (2001)

An affinity resin containing the peptide ligand Phe-Leu-Leu-Val-Pro-Leu (FLLVPL) has been developed for the purification of fibrinogen. The ligand was identified by screening a solid-phase combinatorial peptide library using an immunostaining technique. The specific binding of fibrinogen to the ligand has been characterized by isothermal calorimetry and adsorption isotherms and is dominated by both hydrophobic interactions and ionic interactions with the N-terminal free amino group. The effective association constant of fibrinogen was substantially higher when the peptide was immobilized on the resin than in solution; moreover, it increased with increasing peptide density, suggesting a cooperative binding effect. A low ionic strength buffer at pH 4 was used successfully to elute adsorbed fibrinogen from the column with high purity, retention of factor XIII crosslinking activity, and minimal, if any, loss of biological function. This general approach to ligand selection and characterization can be used to develop peptide ligands for the affinity purification of diverse proteins on a large scale.
Multiple‐profile homogeneous image combination: Application to phase‐cycled SSFP and multicoil imaging (2008)

Signal inhomogeneities in MRI often appear as multiplicative weightings due to various factors such as field-inhomogeneity dependencies for steady-state free precession (SSFP) imaging or receiver sensitivities for coil arrays. These signal inhomogeneities can be reduced by combining multiple data sets with different weights. A sum-of-squares combination is typically used due to its simplicity and near-optimal signal-to-noise ratio (SNR). However, this combination may lead to residual signal inhomogeneity. Alternatively, an optimal linear combination of the data can be performed if the weightings for individual data sets are estimated accurately. We propose a nonlinear combination to improve image-based estimates of the individual weightings. The signal homogeneity can be significantly increased without compromising SNR. The improved performance of the method is demonstrated for SSFP banding artifact reduction and multicoil (phased-array and parallel) image reconstructions.
Effects of MnO-Al2O3 on the Grain Growth and High-Temperature Deformation Strain of UO2 Fuel Pellets (2010)

The fabrication and high-temperature deformation strain of MnO-Al2O3-doped UO2 pelletswere studied. The effects of additive composition and amount on the microstructure evolution of a UO2 pellet were investigated. The compressive creep behaviors of MnO-Al2O3-doped UO2 pellets were examined. The results indicated that a MnO-Al2O3 binary additive can effectively promote the grain growth of UO2 pellets. In addition, the high-temperature deformation strain of the UO2 pellet can be improved significantly with 1,000 ppm 95MnO-5Al2O3 (mol%). The developed MnO-Al2O3-additive-containing UO2 pellets can be a potential candidate for a high-burn-up fuel and a pellet-cladding interaction (PCI)remedy.
A New Methodology for Quantitative LSPR Biosensing and Imaging (2011)

A new quantitative analysis methodology for localized surface plasmon resonance (LSPR) biosensing which determines surface-receptor fractional occupancy, as well as an LSPR imaging technique for the spatiotemporal mapping of binding events, is presented. Electron beam nanolithography was used to fabricate 20 × 20 arrays of gold nanostructures atop glass coverslips. A single biotinylated array was used to measure the association kinetics of neutravidin to the surface by spectroscopically determining the fractional occupancy as a function of time. By regenerating the same array, a reliable comparison of the kinetics could be made between control samples and neutravidin concentrations ranging from 1 μM to 50 nM. CCD-based imagery of the array, taken simultaneously with the spectroscopic measurements, reveals the binding of neutravidin to the surface as manifested by enhanced scattering over the majority of the resonance peak. The temporal resolution of the LSPR imaging technique was 200 ms and the spatial resolution was 8 μm(2).
Efficacy and Safety of a Novel Copper Modulating Agent (WTX-101) for Wilson Disease: Results of a Phase 2, Multi-Center, Open Label Study (P2.026) (2017)

The aim of this study was to evaluate the efficacy and safety of WTX101 in newly diagnosed WD patients.
NRZ Data Asymmetry Corrector and Convolutional Encoder (1983)

Circuit compensates for timing, amplitude and symmetry perturbations. Data asymmetry corrector and convolutional encoder regenerate data and clock signals in spite of signal variations such as data or clock asymmetry, phase errors, and amplitude variations, then encode data for transmission.
Phthalocyanine polymers. I. Poly[2,2′‐(4,4′,4″‐,4‴‐metal phthalocyanino)‐5,5′‐bibenzimidazoles] as new high temperature resistant polymers (1982)

Abstract A novel class of poly(metal phthalocyanino) benzimidazoles were prepared by the condensation reaction between metal (Cu, Co, and Zn), 4,4′,4″,4‴‐tetracarboxyphthalocyanine, and 3,3′‐diaminobenzidine. The reaction was investigated by melt and solution condensation methods. These polymers showed excellent thermal and thermooxidative stability and are noteworthy for their high char yield (86–90%) at 800°C in an anerobic atmosphere. Elemental analyses, spectra, and TGA studies were used to characterize these materials. Isothermal gravimetric analyses were carried out to determine their long‐term thermal stability.
Generation of efficient parsers through direct compilation of XML Schema grammars (2006)

With the widespread adoption of SOAP and Web services, XML-based processing, and parsing of XML documents in particular, is becoming a performance-critical aspect of business computing. In such scenarios, XML is often constrained by an XML Schema grammar, which can be used during parsing to improve performance. Although traditional grammar-based parser generation techniques could be applied to the XML Schema grammar, the expressiveness of XML Schema does not lend itself well to the generic intermediate representations associated with these approaches. In this paper we present a method for generating efficient parsers by using the schema component model itself as the representation of the grammar. We show that the model supports the full expressive power of the XML Schema, and we present results demonstrating significant performance improvements over existing parsers.
Analysis of HLA class II polymorphism using polymerase chain reaction. (1993)

A simple, rapid, and precise method of typing HLA class II polymorphism would be valuable in the areas of disease susceptibility, tissue transplantation, individual identification, and anthropological genetics. Herein, we describe a method of analyzing class II sequence polymorphism based on polymerase chain reaction (PCR) amplification and hybridization with oligonucleotide probes. Many more DNA-defined alleles at the class II loci have been identified than can be distinguished by conventional serologic typing. Consequently, matching transplant donors and recipients by PCR/oligonucleotide typing should reduce graft rejection and graft-vs-host disease. Also, the ability to identify alleles conferring genetic predisposition to specific diseases (eg, insulin-dependent diabetes mellitus) is significantly enhanced by distinguishing the many alleles or "subtypes" within a serologic type (eg, DR4). One valuable property of sequence-based HLA typing strategies, like oligonucleotide probe hybridization, is that they reveal how and where two alleles differ, not simply that they can be operationally distinguished. The nature and location of HLA polymorphisms appears to be critical in disease association studies and are important in tissue typing for transplantation. New alleles at the DRB1, DPB1, and DQB1 loci are likely to be identified as this technology is applied to more and more samples, particularly in nonwhite ethnic groups. A new allele is uncovered as an unusual pattern of probe binding and then confirmed by sequencing. This pattern is observed because class II polymorphism is localized to specific regions and virtually all "new" alleles represent "shuffled" combinations of polymorphic sequences found in previously known alleles. Since these polymorphisms are in the region of probe binding, these new alleles can be detected without increasing the probe panel. Obviously, any new allele with a new polymorphic sequence in a region for which typing probes are not available would not be revealed by oligonucleotide typing. With the PCR primers and probes described here, 7 DQ alpha 1 alleles, 15 DQ beta 1 alleles, 18 DPB1 alleles, and 32 DRB1 alleles are distinguished. Additional primers and/or probes can, of course, increase the allelic discrimination of PCR/oligonucleotide probe typing. These horseradish peroxidase-labeled oligonucleotide probes are stable (> 2 years when stored at 4 degrees C) and the typing system is simple and robust. Although this dot blot/oligonucleotide hybridization procedure is a powerful and precise method of HLA class II typing, the complexity of the procedure increases as the number of probes required for analysis increases.(ABSTRACT TRUNCATED AT 400 WORDS)
Large-signal analysis of directly modulated strongly-injection-locked whistle-geometry ring lasers (2017)

Large-signal analog modulation of a strongly injection-locked whistle-geometry semiconductor ring laser is investigated. Advantages of strong injection locking for high-fidelity large-signal modulation are confirmed through numerical modeling by comparing high-speed performance of a strongly injection-locked whistle-geometry semiconductor ring laser with that of a free-running ring laser.
Wind-tunnel test of the S814 thick root airfoil (1995)

The objective of this wind-tunnel test was to verify the predictions of the Eppler Airfoil Design and Analysis Code for a very thick airfoil having a high maximum lift coefficient (c{sub 1,max} designed to be largely insensitive to leading edge roughness effects. The 24-percent-thick S814 airfoil was designed with these characteristics to accommodate aerodynamic and structural considerations for the root region of a wind-turbine blade. In addition, the airfoil`s maximum lift-to-drag ratio was designed to occur it a high lift coefficient. To accomplish the objective, a two-dimensional wind-tunnel test of the S814 thick root airfog was conducted in January 1994 in the low-turbulence wind tunnel of the Delft University of Technology Low Speed Laboratory. Data were obtained for transition-free and transition-fixed conditions at Reynolds numbers of 0.7, 1.0, 1.5, 2.0, and 3.0 {times} 10{sup 6}. For the design Reynolds numbers of 1.5 {times} l0{sup 6}, the transition-free c{sub 1,max} is 1.3 which satisfies the design specification. However, this value is significantly lower than the predicted c{sub 1,max} of almost l.6. With transition-fixed at the is 1.2. The difference in c{sub 1,max} between the transition-free and transition-fixed conditions demonstrates the airfoil`s minimal sensitivity to roughness effects. The S814 root airfoil was designed to complement existing NREL low c{sub 1,max} tip-region airfoils for rotor blades 10 to 15 meters in length.
Passive state preparation in the Gaussian-modulated coherent-states quantum key distribution (2018)

In the Gaussian-modulated coherent-states (GMCS) quantum key distribution (QKD) protocol, Alice prepares quantum states actively: For each transmission, Alice generates a pair of Gaussian-distributed random numbers, encodes them on a weak coherent pulse using optical amplitude and phase modulators, and then transmits the Gaussian-modulated weak coherent pulse to Bob. Here we propose a passive state preparation scheme using a thermal source. In our scheme, Alice splits the output of a thermal source into two spatial modes using a beam splitter. She measures one mode locally using conjugate optical homodyne detectors, and transmits the other mode to Bob after applying appropriate optical attenuation. Under normal conditions, Alice's measurement results are correlated to Bob's, and they can work out a secure key, as in the active state preparation scheme. Given the initial thermal state generated by the source is strong enough, this scheme can tolerate high detector noise at Alice's side. Furthermore, the output of the source does not need to be single mode, since an optical homodyne detector can selectively measure a single mode determined by the local oscillator. Preliminary experimental results suggest that the proposed scheme could be implemented using an off-the-shelf amplified spontaneous emission source.