gebhart/patrepeval huggingface dataset:
Fracture Toughness and Fatigue Crack Propagation Rate of Short Fiber Reinforced Epoxy Composites for Analogue Cortical Bone (2007)

Third-generation mechanical analogue bone models and synthetic analogue cortical bone materials manufactured by Pacific Research Laboratories, Inc. (PRL) are popular tools for use in mechanical testing of various orthopedic implants and biomaterials. A major issue with these models is that the current third-generation epoxy-short fiberglass based composite used as the cortical bone substitute is prone to crack formation and failure in fatigue or repeated quasistatic loading of the model. The purpose of the present study was to compare the tensile and fracture mechanics properties of the current baseline (established PRL "third-generation" E-glass-fiber-epoxy) composite analogue for cortical bone to a new composite material formulation proposed for use as an enhanced fourth-generation cortical bone analogue material. Standard tensile, plane strain fracture toughness, and fatigue crack propagation rate tests were performed on both the third- and fourth-generation composite material formulations using standard ASTM test techniques. Injection molding techniques were used to create random fiber orientation in all test specimens. Standard dog-bone style tensile specimens were tested to obtain ultimate tensile strength and stiffness. Compact tension fracture toughness specimens were utilized to determine plane strain fracture toughness values. Reduced thickness compact tension specimens were also used to determine fatigue crack propagation rate behavior for the two material groups. Literature values for the same parameters for human cortical bone were compared to results from the third- and fourth-generation cortical analogue bone materials. Tensile properties of the fourth-generation material were closer to that of average human cortical bone than the third-generation material. Fracture toughness was significantly increased by 48% in the fourth-generation composite as compared to the third-generation analogue bone. The threshold stress intensity to propagate the crack was much higher for the fourth-generation material than for the third-generation composite. Even at the higher stress intensity threshold, the fatigue crack propagation rate was significantly decreased in the fourth-generation composite compared to the third-generation composite. These results indicate that the bone analogue models made from the fourth-generation analogue cortical bone material may exhibit better performance in fracture and longer fatigue lives than similar models made of third-generation analogue cortical bone material. Further fatigue testing of the new composite material in clinically relevant use of bone models is still required for verification of these results. Biomechanical test models using the superior fourth-generation cortical analogue material are currently in development.
Manifestation of Sea Quark Effects in the Strong Coupling Constant in Lattice QCD (1995)

We demonstrate that sea quark effects of a magnitude expected from renormalization group considerations are clearly visible in the strong coupling constant measured in current full QCD simulations. Building on this result an estimate of ${\ensuremath{\alpha}}_{\stackrel{-}{\mathrm{MS}}}^{(5)}({M}_{Z})$ ($\stackrel{-}{\mathrm{MS}}$ denotes the modified minimal subtraction scheme) is made employing the charmonium $1S\ensuremath{-}1P$ mass splitting calculated on full QCD configurations generated with two flavors of dynamical Kogut-Susskind quarks to fix the scale.
Disulfide Bond Structure and Domain Organization of Yeast β(1,3)-Glucanosyltransferases Involved in Cell Wall Biogenesis (2008)

The Gel/Gas/Phr family of fungal beta(1,3)-glucanosyltransferases plays an important role in cell wall biogenesis by processing the main component beta(1,3)-glucan. Two subfamilies are distinguished depending on the presence or absence of a C-terminal cysteine-rich domain, denoted "Cys-box." The N-terminal domain (NtD) contains the catalytic residues for transglycosidase activity and is separated from the Cys-box by a linker region. To obtain a better understanding of the structure and function of the Cys-box-containing subfamily, we identified the disulfide bonds in Gas2p from Saccharomyces cerevisiae by an improved mass spectrometric methodology. We mapped two separate intra-domain clusters of three and four disulfide bridges. One of the bonds in the first cluster connects a central Cys residue of the NtD with a single conserved Cys residue in the linker. Site-directed mutagenesis of the Cys residue in the linker resulted in an endoplasmic reticulum precursor that was not matured and underwent a gradual degradation. The relevant disulfide bond has a crucial role in folding as it may stabilize the NtD and facilitate its interaction with the C-terminal portion of a Gas protein. The four disulfide bonds in the Cys-box are arranged in a manner consistent with a partial structural resemblance with the plant X8 domain, an independent carbohydrate-binding module that possesses only three disulfide bonds. Deletion of the Cys-box in Gas2 or Gas1 proteins led to the formation of an NtD devoid of any enzymatic activity. The results suggest that the Cys-box is required for proper folding of the NtD and/or substrate binding.
Management Training for Pathology Residents:<i>I. Results of a National Survey</i> (1994)

The professional activities of anatomic and clinical pathologists involve, to a large extent, management issues. To evaluate the management training received by pathology residents, the authors surveyed pathology residency training programs in the United States. Responses were collected from 138 of 187 programs (73.8% response rate). Of the 138 programs, 61 reported that they had a formal training program in management, with an average of 26.8 +/- 4.9 (standard error) hours/year devoted to this discipline. Directors of 64.5% of the programs felt that management training should be expanded. Lectures were used in 61% of the programs, some in combination with case studies. Elements of training in fiscal management were present in 52.8% of the programs, and the presence of fiscal management training was associated significantly with a greater number of hours spent in management training (P < .001). Training in traditional laboratory management and quality control was included in 91.5% of the programs. The principles of total quality management were discussed in only 31.7% of the programs, but 80.6% of the programs encouraged residents' participation in departmental or institutional total quality management activities. These data indicate that there are major differences in the quality of and emphasis on management training for pathology residents in the United States.
Influence of incident angle on distance detection accuracy of point laser probe with charge-coupled device: prediction and calibration (2012)

Point laser probes (PLPs) with charge-coupled device (CCD) are widely used in industry engineering. However, the distance detection accuracy is significantly affected by incident angle, which limits the application in free-form surface measurement. To analyze the influence of incident angle, a reference distance is first determined under normal incidence. Then the detection errors are estimated by the relative differences of non-zero incident angles from the reference. Based on laser ray tracking strategy and superposition principle, an intensity spot is formed on the detector plane. The image deviation is assessed using a robust subpixel algorithm. Therefore the distance detection error can be numerically predicted. As a comparison, a precision calibration system is set up, which is composed of CCD-PLP, data card, human manual interface, pulse controller, step motor driver, and calibration device. A calibration procedure was programmed on the upper PC. Thus data sampling, angle control, and error assessment can be achieved. A series of prediction and calibration tests covering angle range from −55 deg to 55 deg were conducted on a five-axis machining center. The results indicate that the trend of calibration was quite coincident with that predicted. The distance detection error has an approximate linear function of incident angle.
Effect of Photo-active Compound Structure on Photosensitivity of Positive Photosensitive Polyimide (2006)

The photo-active compound (PAC) in positive tone photosensitive polyimide (posi PSPI) was investigated in order to obtain good photo lithographic performance (small development loss and good photosensitivity). When the PAC structure was changed posi PSPI showed different levels of photosensitivity and development loss. The development loss and photosensitivity showed a good correlation. The lower development loss posi PSPI showed lower photosensitivity. From the molecular orbital calculation, the PAC in the lower development loss posi PSPI had a lower dipole moment than that in the larger development loss posi PSPI. In addition, dissolution rate measurement (DRM) results suggest that posi PSPI may have two layers from the point of dissolution. The dissolution rate of the surface layer in posi PSPI was shown to be lower than that of a bottom layer. This suggests that PAC using the lower development loss posi PSPI may exist mainly on its surface. These results are quite important for the design of good posi PSPI.
Time-resolved impulse response of the magnetoplasmon resonance in a two-dimensional electron gas (2002)

We have used optically excited ultrashort electrical pulses to measure the magnetoplasmon resonance of a two-dimensional electron gas formed in an AlGaAs/GaAs heterostructure at frequencies up to 200 GHz. This is accomplished by incorporating the sample into a guided wave probe operating in a pumped ${}^{3}\mathrm{He}$ system. We are able to detect the resonance by launching a stimulus pulse in the guide, and monitoring the system response in a time-resolved pump-probe arrangement. Data obtained from measurements yield resonant frequencies that agree with the magnetoplasmon dispersion relation.
OpenFlow Configuration Protocol: Implementation for the of Management Plane (2013)

Separation of data and control plane offers benefits of having programmability of the forwarding tables according to the needs of the applications. The need for efficient and effective management of network resources is crucial in providing effective control plane functionality to the applications. OpenFlow standardization efforts at Open Networking Foundation resulted in an OpenFlow Configuration specification to address the management of resources in OpenFlow-enabled switches. We report the implementation of the OF-Config 1.1 standard [revision - 25th June 2012] as softconf.d to retrieve and update the controller IP of an OpenvSwitch.
Fetish, Sacrifice and Tragic Freedom in the Dardenne Brothers' La Promesse (2016)

Fetish, Sacrifice and Tragic Freedom and in the Dardenne Brothers’ La Promesse (Abstract) The purpose of this article is to begin drawing attention to the strong likelihood that Freud’s Totem and Taboo (1913) contributed important ideas to the creation of La Promesse (1996) by Luc and Jean-Pierre Dardenne. In the current article, we take note of just two of its most important aspects: animism, and the childlike recurrence of totemism. In La Promesse, these concepts are elaborated in relationship to a small African statue present in the home of the West African illegal immigrants, Assita and Hamidou. The sculpture – which Freud would call a fetish – is a locus of mysterious spiritual forces (Freud’s “animism”), which, together with Assita, contribute to bringing Igor to a greater personal and spiritual maturity. Igor eventually rejects his father’s world (which casually includes the Christian God, whenever it suits the father’s needs), and freely accepts affiliation with his new pseudo-mother Assita and the blend of African spirituality which is part and parcel of her world. The film’s narrative is given considerable depth due to the inclusion of complex echoes of the sacrifice of Abraham from Biblical culture, and the oedipal structures of tragic self-discovery from Ancient Greece. The directors skillfully empower the West African statue as a catalyst activating all these layers of meaning.
Immunotherapy in Lung Cancer: Current Landscape and Future Directions (2022)

Over the past decade, lung cancer treatment has undergone a major paradigm shift. A greater understanding of lung cancer biology has led to the development of many effective targeted therapies as well as of immunotherapy. Immune checkpoint inhibitors (ICIs) have shown tremendous benefit in the treatment of non-small cell lung cancer (NSCLC) and are now being used as first-line therapies in metastatic disease, consolidation therapy following chemoradiation in unresectable locally advanced disease, and adjuvant therapy following surgical resection and chemotherapy in resectable disease. Despite these benefits, predicting who will respond to ICIs has proven to be difficult and there remains a need to discover new predictive immunotherapy biomarkers. Furthermore, resistance to ICIs in lung cancer is frequent either because of a lack of response or disease progression after an initial response. The utility of ICIs in the treatment of small cell lung cancer (SCLC) remains limited to first-line treatment of extensive stage disease in combination with chemotherapy with modest impact on overall survival. It is thus important to explore and exploit additional targets to reap the full benefits of immunotherapy in the treatment of lung cancer. Here, we will summarize the current state of immunotherapy in lung cancer, discuss novel targets, and explore the intersection between DNA repair defects and immunotherapy.
Facile promoter deletion in Escherichia coli in response to leaky expression of very robust and benign proteins from common expression vectors (2009)

The deletions in the insufficiently repressed system are caused entirely by the burden of high-level translation. Since the E. coli Dps protein, known to protect DNA against stress in the stationary phase, is accumulated in the deletion mutants, the mutation may have taken place during a transient stationary phase. The cause of the deletion is thus distinct from the well known interference of high-level transcription with plasmid replication. The deletion can be entirely prevented by overexpressing LacI, a useful precaution even without any signs of stress caused by the protein.
Applying Radio Environment Maps to Cognitive Wireless Regional Area Networks (2007)

The IEEE 802.22 wireless regional area network (WRAN) is the first worldwide commercial application of cognitive radio (CR) networks refarming the TV broadcast bands. According to US FCC's recent public notice, WRAN products are scheduled to be available for the market by February, 2009. This paper first presents a brief review of the IEEE 802.22 WRAN standardization, and then introduces the radio environment map (REM) as an innovative cost-efficient approach to developing and managing WRAN systems. REMs can provide powerful infrastructure support to the functionality of the WRAN cognitive engine (CE). The data model of the REM is presented together with an extensive discussion on how to exploit the REM for a variety of applications in WRAN systems, focusing on the REM-enabled case- and knowledge-based learning algorithms (REM-CKL) for WRAN CEs. Furthermore, REM-based radio scenario-driven testing (REM-SDT) is also presented as a viable approach to evaluating the performance of CEs. Future research topics are discussed in the final section.
The Transmission of Knowledge in Al-Andalus (Up to 300/912) (2017)

This article examines the spread of knowledge in al-Andalus by reconstructing the most important groups of masters according to the number of their disciples. In studying the period in question, in which a total of 1,631 savants—or individuals related to the intellectual life—have been registered, a group of 279 personalities stands out, with at least one disciple each. Within this group, 22 masters are notable as having had more than 10 disciples each. This group may, therefore, be considered the veritable elite among the transmitters of knowledge in al-Andalus. This article also indicates the most important masters of each generation and the relationships that existed between them, by means of the groups of disciples they had in common.
Botulinum toxin: A potential alternative to current treatment of neurogenic and idiopathic urinary incontinence due to detrusor overactivity (2006)

Botulinum toxin-A has emerged as a promising option for the treatment of neurogenic and refractory idiopathic detrusor overactivity. Studies to date have shown that not only is this treatment effective at decreasing urinary symptoms and incontinence, as well as improving potentially dangerous urodynamic measures, but it is also minimally invasive, reversible and safe. Questions over proper dosing and dilution, number of injection sites, and re-injection rates remain to be answered.
Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients (2013)

In contrast to normal healing wounds, chronic wounds commonly show disturbances in proteins regulating wound healing processes, particularly those involved in cell proliferation and protein degradation. Multidimensional protein identification technology MS/MS was conducted to investigate and compare the protein composition of chronic diabetic foot exudates to exudates from split-skin donor sites of burn victims otherwise healthy. Spectral counting revealed 188 proteins differentially expressed (more than twofold and p-value <0.05) in chronic wounds. Most were involved in biological processes including inflammation, angiogenesis, and cell mortality. Increased expression of the inflammatory response stimulating S100 proteins, predominantly S100A8 and S100A9 (almost tenfold), was identified. Matrix metalloproteinases (MMPs) MMP1, MMP2, and MMP8 were identified to be elevated in chronic wounds with significant impact on collagen degradation and tissue destruction. Further, proteins with antiangiogenic properties were found at higher expression levels in chronic wounds. Reduced angiogenesis leads to drastic shortage in nutrition supply and causes increased cell death, demonstrated by Annexin A5 exclusively found in chronic wound exudates. However, excessive nucleic and cytosolic material infers cell death occurring not only by apoptosis but also by necrosis. In conclusion, mass spectrometric investigation of exudates from chronic wounds demonstrated dramatic impairment in wound repair with excessive inflammation, antiangiogenic environment, and accelerated cell death.
Nicotinamide Phosphoribosyltransferase Inhibitor Is a Novel Therapeutic Candidate in Murine Models of Inflammatory Lung Injury (2014)

We previously identified the intracellular nicotinamide phosphoribosyltransferase (iNAMPT, aka pre-B-cell colony enhancing factor) as a candidate gene promoting acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) with circulating nicotinamide phosphoribosyltransferase potently inducing NF-κB signaling in lung endothelium. iNAMPT also synthesizes intracellular nicotinamide adenine dinucleotide (iNAD) in response to extracellular oxidative stress, contributing to the inhibition of apoptosis via ill-defined mechanisms. We now further define the role of iNAMPT activity in the pathogenesis of ARDS/VILI using the selective iNAMPT inhibitor FK-866. C57/B6 mice were exposed to VILI (40 ml/kg, 4 h) or LPS (1.5 mg/kg, 18 h) after osmotic pump delivery of FK-866 (100 mg/kg/d, intraperitoneally). Assessment of total bronchoalveolar lavage (BAL) protein, polymorphonuclear neutrophil (PMN) levels, cytokine levels (TNF-α, IL-6, IL-1α), lung iNAD levels, and injury scores revealed that FK-866-mediated iNAMPT inhibition successfully reduced lung tissue iNAD levels, BAL injury indices, inflammatory cell infiltration, and lung injury scores in LPS- and VILI-exposed mice. FK-866 further increased lung PMN apoptosis, as reflected by caspase-3 activation in BAL PMNs. These findings support iNAMPT inhibition via FK-866 as a novel therapeutic agent for ARDS via enhanced apoptosis in inflammatory PMNs.
Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity (2016)

Caged Garcinia xanthones (CGXs) constitute a family of natural products that are produced by tropical/subtropical trees of the genus Garcinia CGXs have a unique chemical architecture, defined by the presence of a caged scaffold at the C ring of a xanthone moiety, and exhibit a broad range of biological activities. Here we show that synthetic CGXs exhibit antimalarial activity against Plasmodium falciparum, the causative parasite of human malaria, at the intraerythrocytic stages. Their activity can be substantially improved by attaching a triphenylphosphonium group at the A ring of the caged xanthone. Specifically, CR135 and CR142 were found to be highly effective antimalarial inhibitors, with 50% effective concentrations as low as ∼10 nM. CGXs affect malaria parasites at multiple intraerythrocytic stages, with mature stages (trophozoites and schizonts) being more vulnerable than immature rings. Within hours of CGX treatment, malaria parasites display distinct morphological changes, significant reduction of parasitemia (the percentage of infected red blood cells), and aberrant mitochondrial fragmentation. CGXs do not, however, target the mitochondrial electron transport chain, the target of the drug atovaquone and several preclinical candidates. CGXs are cytotoxic to human HEK293 cells at the low micromolar level, which results in a therapeutic window of around 150-fold for the lead compounds. In summary, we show that CGXs are potent antimalarial compounds with structures distinct from those of previously reported antimalarial inhibitors. Our results highlight the potential to further develop Garcinia natural product derivatives as novel antimalarial agents.
Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis (2007)

This study provides no evidence to justify continued use of n-acetylcysteine, selenium, vitamin C based antioxidant therapy in severe acute pancreatitis. In the context of any future trial design, careful consideration must be given to the risks raised by the greater trend towards adverse outcome in patients in the treatment arm of this study.
Phased Array Antenna Handbook, Third Edition (2017)

This completely revised third edition of an Artech House classic, Phased Array Antenna Handbook, Second Edition, offers an up-to-date and comprehensive treatment of array antennas and systems. This edition provides a wealth of new material, including expanded coverage of phased array and multiple beam antennas. New modern machine learning techniques used for analysis are included. Additional material on wideband antennas and wideband coverage in array antennas are incorporated in this book, including new methods, devices, and technologies that have developed since the second edition. A detailed treatment of antenna system noise, sections on antenna pattern synthesis, developments in subarray technology, and in-depth coverage of array architecture and components are additional new features of this book. The book explores design elements that demonstrate how to size an array system with speed and confidence. Moreover, this resource provides expanded coverage of systems aspects of arrays for radar and communications. Supported with numerous equations and illustrations, this practical book helps evaluate basic antenna parameters such as gain, sidelobe levels, and noise. Readers learn how to compute antenna system noise, design subarray geometries for given bandwidth, scan and sidelobe constraints, and choose array illumination tapers for given sidelobe levels.