gebhart/patrepeval huggingface dataset:
Modifications of electrode design for recording monophasic action potentials in animals and humans (1987)

An Ag-AgCl electrode for recording monophasic action potentials by pressure contact is described. The electrode is mounted in a hand-held support designed for epicardial recordings during open-heart surgery from both the anterior and lateral walls of the left ventricle with minimal displacement of the heart. The support allows the electrode to be manipulated without the need for direct vision by the surgeon to any desired position while ensuring perpendicular apposition of the electrode without risk of damage to the myocardium. The permanently mounted electrode is also suitable for animal experiments. The electrode may be used for endocardial recordings in animals by direct puncture. Either a straight or curved electrode may be chosen as dictated by the recording site. The monophasic action potentials recorded by this electrode are of a high quality in terms of configuration, lack of drift, and amplitude.
Inhibition of Nitric Oxide With Aminoguanidine Reduces Bacterial Translocation After Endotoxin Challenge In Vivo (1996)

Inhibition of nitric oxide production with AG decreases BT after high-dose LPS challenge. The mechanism may involve increased cellular viability and decreased damage to the gut mucosal barrier in rats that receive AG.
Enhancing thermal properties of W/Cu composites (2001)

Two alternative techniques based on coating and chemical co-synthesis for making W/Cu powder composite with improved thermal properties were evaluated. The properties of W/Cu synthesised by these techniques were compared with mechanically blended powders. The distribution of copper in the consolidated samples was analysed using an optical microscope. The influence of copper distribution on the properties, such as thermal conductivity and coefficient of thermal expansion, was evaluated. The thermal conductivity of a coated sample was the highest (190 W m −1 K −1 ) when compared with that of co-synthesised (140 W m −1 K −1 ) and ball milled (165 W m −1 K −1 ) specimens. Although the co-synthesised sample has the better distribution of copper in the tungsten matrix, the poor densification was attributed to the lack of formation of continuity among copper phase. The coated sample has a lower thermal expansion coefficient (4·7 ppm/K) than that of co-synthesised sample (6·8 ppm/K).
EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance (2009)

Overexpression of the polycomb group protein enhancer of zeste homologue 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and glioblastoma multiforme (GBM). Based on its ability to modulate transcription of key genes implicated in cell cycle control, DNA repair, and cell differentiation, EZH2 is believed to play a crucial role in tissue-specific stem cell maintenance and tumor development. Here, we show that targeted pharmacologic disruption of EZH2 by the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin A (DZNep), or its specific downregulation by short hairpin RNA (shRNA), strongly impairs GBM cancer stem cell (CSC) self-renewal in vitro and tumor-initiating capacity in vivo. Using genome-wide expression analysis of DZNep-treated GBM CSCs, we found the expression of c-myc, recently reported to be essential for GBM CSCs, to be strongly repressed upon EZH2 depletion. Specific shRNA-mediated downregulation of EZH2 in combination with chromatin immunoprecipitation experiments revealed that c-myc is a direct target of EZH2 in GBM CSCs. Taken together, our observations provide evidence that direct transcriptional regulation of c-myc by EZH2 may constitute a novel mechanism underlying GBM CSC maintenance and suggest that EZH2 may be a valuable new therapeutic target for GBM management.
Performance on PBI/H_3PO_4 Proton Conducting Membrane Fuel Cell Using Ethane as Fuel (2010)

Performance of fuel cell using ethane as fuel, polybenzimidazole (PBI) membrane doping H3PO4 as proton-conducting membrane, Pt/C as electrode catalysts was investigated. Proton conducting membrane of PBI/ H3PO4 was prepared by solution casting method. Relation of H3PO4 doped amount in PBI membrane and doped time was observed. Electrochemical performances of PBI/H3PO4 proton-conducting membrane fuel cell were compared under the conditions with ethane humidification or without ethane humidification. Reaction mechanism of fuel cell and effect of different operation temperatures on fuel cell performance were explored. The experimental results showed that H3PO4 doped amount in PBI membrane and doped time were 600mol% H3PO4 and 8h, respectively. Cell performance became better after ethane humidification. Output current and power densities of cell increased with increasing operational temperature. This is attributed to improved reaction rate of electrodes. The maximum current and power densities of 1.5mA·cm-2 and 0.33 mW·cm-2 at ethane humidity of 0, and of 34 mA·cm-2 and 5.5 mW·cm-2 at ethane humidity of 0.02 kg H2O/kg ethane, for the single fuel cell having the configuration of C2H6, (Pt/C anode)/PBI/H3PO4 membrane /(Pt/C cathode), O2 were obtained at 200 ℃ and 0.1 MPa, respectively.
Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines (2013)

ETS transcription factors mediate a wide array of cellular functions and are attractive targets for pharmacological control of gene regulation. We report the inhibition of the ETS-family member PU.1 with a panel of novel heterocyclic diamidines. These diamidines are derivatives of furamidine (DB75) in which the central furan has been replaced with selenophene and/or one or both of the bridging phenyl has been replaced with benzimidazole. Like all ETS proteins, PU.1 binds sequence specifically to 10-bp sites by inserting a recognition helix into the major groove of a 5'-GGAA-3' consensus, accompanied by contacts with the flanking minor groove. We showed that diamidines target the minor groove of AT-rich sequences on one or both sides of the consensus and disrupt PU.1 binding. Although all of the diamidines bind to one or both of the expected sequences within the binding site, considerable heterogeneity exists in terms of stoichiometry, site-site interactions and induced DNA conformation. We also showed that these compounds accumulate in live cell nuclei and inhibit PU.1-dependent gene transactivation. This study demonstrates that heterocyclic diamidines are capable of inhibiting PU.1 by targeting the flanking sequences and supports future efforts to develop agents for inhibiting specific members of the ETS family.
Report: Third Annual Monetizing Stranded Gas Reserves Conference (2000)

The Third Annual Monetizing Stranded Gas Reserves Conference was held on 7–9 December 1999 in Houston, Texas. This international event featured presentations covering the opportunities which are open to companies and organisations that are involved in using and marketing unvalued gas reserves. Some of the technologies being developed for this field use membranes, and so the presentations are worthy of coverage, and will be of general interest to those working in the membrane industry. Here, we offer a résumé of the event, which was organised by US-based Zeus Development Corporation, and sponsored, among others, by Syntroleum, Black & Veatch, Methanex and the Alaska North Slope LNG Project.
PPAR&gamma; agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer&rsquo;s disease: in vitro and in vivo studies (2018)

PLGA-PEG nanocarriers cross brain endothelium by transcytosis and can be loaded with a pharmaceutical agent to effectively treat a mouse model of AD.
A new P-chiral aminophosphine ligand containing a 2,2′-coupled pyrrolidine–phospholane ring system. Synthesis and coordination properties with rhodium(<scp>I</scp>) and iridium(<scp>I</scp>) fragments (1995)

A new approach to the synthesis of chiral P,N-ligands containing a stereogenic phosphorus atom is reported; the synthesis, characterization and coordination properties of (PR, 2R, 3R, 2′R, 3′S, 4′S) 2[2′(3′,4′-di-tert-butoxy-1′-methyltetrahydropyrrolyl)]-3-methoxy-1-phenyltetrahydrophosphole (P*-N-1), which contains a stereogenic phosphorus in addition to five contiguous stereocentres in the ligand backbone; compound P*-N-1 represents the first example of a new class of chiral P,N-ligands with the heteroatoms incorporated in two 2,2′-coupled pyrrolidine–phospholane rings.
Intrinsic Double-Stranded-RNA Processing Activity of <i>Escherichia coli</i> Ribonuclease III Lacking the dsRNA-Binding Domain (2001)

The ribonuclease III superfamily represents a structurally related group of double-strand (ds) specific endoribonucleases which play key roles in diverse prokaryotic and eukaryotic RNA maturation and degradation pathways. A dsRNA-binding domain (dsRBD) is a conserved feature of the superfamily and is important for substrate recognition. RNase III family members also exhibit a "catalytic" domain, in part defined by a set of highly conserved amino acids, of which at least one (a glutamic acid) is important for cleavage but not for substrate binding. However, it is not known whether the catalytic domain requires the dsRBD for activity. This report shows that a truncated form of Escherichia coli RNase III lacking the dsRBD (RNase III[DeltadsRBD]) can accurately cleave small processing substrates in vitro. Optimal activity of RNase III[DeltadsRBD] is observed at low salt concentrations (<60 mM Na(+)), either in the presence of Mg(2+) (>25 mM) or Mn(2+) ( approximately 5 mM). At 60 mM Na(+) and 5 mM Mn(2+) the catalytic efficiency of RNase III[DeltadsRBD] is similar to that of RNase III at physiological salt concentrations and Mg(2+). In the presence of Mg(2+) RNase III[DeltadsRBD] is less efficient than the wild-type enzyme, due to a higher K(m). Similar to RNase III, RNase III[DeltadsRBD] is inhibited by high concentrations of Mn(2+), which is due to metal ion occupancy of an inhibitory site on the enzyme. RNase III[DeltadsRBD] retains strict specificity for dsRNA, as indicated by its inability to cleave (rA)(25), (rU)(25), or (rC)(25). Moreover, dsDNA, ssDNA, or an RNA-DNA hybrid are not cleaved. Low (micromolar) concentrations of ethidium bromide block RNase III[DeltadsRBD] cleavage of substrate, which is similar to the inhibition seen with RNase III and is indicative of an intercalative mode of inhibition. Finally, RNase III[DeltadsRBD] is sensitive to specific Watson-Crick base-pair substitutions which also inhibit RNase III. These findings support an RNase III mechanism of action in which the catalytic domain (i) can function independently of the dsRBD, (ii) is dsRNA-specific, and (iii) participates in cleavage site selection.
Matrix Metalloproteinase-9 and Myeloperoxidase Expression (2004)

In this model, neutrophils are not the primary source of MMP-9 protein and thus are unlikely the key contributor to BBB breakdown observed in SOD2-KOs.
Oldie but Goldie: Bristow-Latarjet Procedure for Anterior Shoulder Instability (2007)

The Bristow-Latarjet procedure is a good surgical treatment for recurrent anterior-inferior instability of the glenohumeral joint.
Data-to-Text Generation Improves Decision-Making Under Uncertainty (2017)

Decision-making is often dependent on uncertain data, e.g. data associated with confidence scores or probabilities. This article presents a comparison of different information presentations for uncertain data and, for the first time, measures their effects on human decision-making, in the domain of weather forecast generation. We use a game-based setup to evaluate the different systems. We show that the use of Natural Language Generation (NLG) enhances decision-making under uncertainty, compared to state-of-the-art graphical-based representation methods. In a task-based study with 442 adults, we found that presentations using NLG led to 24% better decision-making on average than the graphical presentations, and to 44% better decision-making when NLG is combined with graphics. We also show that women achieve significantly better results when presented with NLG output (an 87% increase on average compared to graphical presentations). Finally, we present a further analysis of demographic data and its impact on decision-making, and we discuss implications for future NLG systems.
An Exploratory Study of Cross Border E-commerce (CBEC) in China: Opportunities and Challenges for Small to Medium Size Enterprises (SMEs) (2018)

Development of cross border e-commerce (CBEC) is one of the major enablers of SMEs access to overseas market opportunities. The boom in China's cross border e-commerce has been exponential. It has made China the world's largest cross-border market with over 200 million cross-border online consumers. This article explores the opportunities and the challenges for SMEs to leverage the China's CBEC to find and develop new customers in markets outside their domestic ones. It aims to help small to medium enterprises understand the unique Chinese e-commerce ecosystem and develop an appropriate e-commerce strategy that enables them to enter the Chinese e-commerce ecosystem. This research reveals that the significant growth opportunities and challenges for those SMEs poised for business expansion into Chinese market via CBEC and offers a detailed understanding of the China's cross border ecommerce system. SMEs are a major and important part of the world economy in terms of making contribution to Gross Domestic Product (GDP) and employment. It is important to help SMEs to understand the significance of cross border e-commerce ecosystem and develop an appropriate e-commerce strategy that enables them to engage with CBEC and empower them to maximize the opportunities offered by CBEC in China. This article recommends that SMEs take a proactive approach to developing effective digital marketing strategies to engage with Chinese online consumers and keep up with new policies, programs and regulatory changes introduced by Chinese governments in a fast changing digital environment. It also suggests that SMEs consider cooperation with an online retailer who is present on China's cross border B2C platforms to yield better results for brand building and direct sale.
Fabrication and High Electrocatalytic Activity of Three-Dimensional Porous Nanosheet Pt/Boron-Doped Diamond Hybrid Film (2009)

A three-dimensional (3-D) Pt nanosheet perpendicular to boron-doped diamond (BDD) hybrid film surface was prepared by the double template method, with a hydrogen bubble template and subsequent metallic Zn template to control the morphology of the Pt catalyst on the BDD surface. The porous Zn nanostructured template on oxygen-terminated BDD was first synthesized by electrodeposition with a concomitant hydrogen bubble as a dynamic template. Then a porous Pt nanostructure was obtained by immersing the Zn nanostructure in H2PtCl6 aqueous solution for a typical displacement reaction. Field emission scanning electron microscopy (FESEM) revealed that the morphology of the Zn template obtained was a 3-D porous nanosheet structure perpendicular to the BDD thin film surface, and Pt kept the morphology of the Zn template after the displacement reaction. Energy dispersive spectrometry (EDS) and X-ray diffraction (XRD) revealed that the Pt nanosheet obtained was the classical face-centered cubic (fcc) pattern. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed to evaluate methanol electro-oxidation performance of the 3-D Pt nanosheet/BDD electrode. The results indicated that the electrode had a high electrocatalytic ability resulting from the large surface area and porous structure, which efficiently facilitates the transportation of reactants and products, and an antipoisoning ability due to the support activity of BDD.
Hidden Ancient Records Abound (2001)

Book Review| January 01 2001 Hidden Ancient Records Abound The Book of Mormon and Other Hidden Books: "Out of Darkness unto Light", John A. Tvedtnes. Marilyn Arnold Marilyn Arnold Search for other works by this author on: This Site Google FARMS Review of Books (2001) 13 (2001) (2): 53–56. https://doi.org/10.2307/44795376 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Marilyn Arnold; Hidden Ancient Records Abound. FARMS Review of Books 1 January 2001; 13 (2001) (2): 53–56. doi: https://doi.org/10.2307/44795376 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressMormon Studies Review Search Advanced Search The text of this article is only available as a PDF. © 2002 Foundation for Ancient Research and Mormon Studies Brigham Young University2002 Article PDF first page preview Close Modal Issue Section: The Book of Mormon You do not currently have access to this content.
Adaptive matched subspace detectors and adaptive coherence estimators (2002)

We adapt the matched subspace detectors (MSDs) of Scharf (1991) and Scharf and Friedlander (see IEEE Trans. Signal Proc., vol.42, no.8. p.2146-57, 1994) to unknown noise covariance matrices in order to produce adaptive MSDs that may be applied to signal detection in radar, sonar, mobile communication, and DOA estimation. A special case of the adaptive MSD uses the Reed (1974) ratio statistic and a special cease of the adaptive CFAR MSD uses an adaptive coherence estimator (ACE). We compare and contrast the invariances and performance of the two detectors and discuss extensions of them that make them maximum likelihood MSDs.
Influence of output impedance on power added efficiency of Si-bipolar power transistors (2002)

The power added efficiency (PAE) of low voltage RF bipolar power transistors for cellular applications, is carefully analyzed experimentally and theoretically. We found that the transistor with low output capacitance operates in "inverse class AB", which facilitates high efficiencies. FE as high as 77% at 1.8 GHz with 3.5 V supply voltage have been obtained.
Design and analysis of kinematic couplings for modular machine and instrument structures (2002)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.
Bicalutamide for advanced prostate cancer: the natural versus treated history of disease. (1997)

Classifying patient tumors on the basis of prior hormone exposure permits a more precise estimate of the potential benefit of a specific hormone therapy for the individual patient. The precision is further increased by reporting the effects of a drug on each parameter of disease independently. The difference in outcomes for patients with androgen-independent progression suggests that the specific hormone therapy administered and the response to that therapy can influence the biology of the relapsing tumor and the sensitivity to subsequent therapies. The sensitivity to bicalutamide after progression on flutamide deserves further study.
Serum Level of the Phosphaturic Factor FGF23 Is Associated with Abdominal Aortic Calcification in Men: The STRAMBO Study (2012)

In healthy older men, circulating FGF23 is associated with parameters of mineral metabolism, including bone metabolism-regulating cytokines, and with severe AAC independent of traditional risk factors.
<i>I</i> <i>n</i> <i>s</i> <i>i</i> <i>t</i> <i>u</i> x-ray photoelectron spectroscopic study of remote plasma enhanced chemical vapor deposition of silicon nitride on sulfide passivated InP (1990)

The changes in chemical composition and Fermi level position of n- and p-InP surfaces induced by reactions with sodium sulfide and ammonium sulfide solutions and with vapor from ammonium sulfide solution have been characterized by x-ray photoelectron spectroscopy (XPS). Further, in situ XPS analysis was used to study interfaces formed on sulfide passivated surfaces by remote plasma enhanced chemical vapor deposition of silicon nitride. We found that both indium and phosphorus sulfide phases were formed as a result of exposing InP to sulfide vapor at room temperature. However, most of the surface native sulfides dissolved in water and the resultant surface was then covered with about one monolayer of indium sulfide. Further, reduction in donor states in the upper band gap was evident by these sulfide treatments. However, heating the sulfide passivated sample caused an increase in surface states. Sulfur doping effect was also observed upon heating InP covered with the air oxidation products of the sulfide vapor. In the study of silicon nitride deposition, we found that the formation of native nitride could be avoided by optimizing the processing parameters. In addition, we also found that the surface native sulfide on InP reacted with the deposited silicon nitride. Capitance–voltage (C–V) data collected at 1 MHz indicate that a low interface state density could be obtained on silicon nitride/sulfide passivated InP. However, measurements of surface band bending of InP as a function of charging potential on a 10 nm silicon nitride on InP by XPS indicate that slow surface states were present which restricted changes in band bending to less than 0.3 eV when the applied voltage on the thin dielectric was −2 V.
ChemInform Abstract: An Enhanced CVD Approach to Extensive Nanotube Networks with Directionality. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mending the Fracture: Bringing Parties Together on High Volume Hydraulic Fracturing Through Alternative Dispute Resolution (2012)

Natural gas is poised to make a significant impact on America's energy future.'According to the United States Energy Information Administration, natural gas supplied approximately 25 percent of the United States' energy demand in 2010.2The U.S. has abundant natural gas resources, and current estimates of the recoverable resource suggest that there is enough natural gas to supply the country for the next 90 years. 3 Nevertheless, in recent years, conventional gas reserves, such as those found in the Gulf of Mexico, Kansas, and New Mexico, 4 have been declining, while unconventional natural gas, found in shale formations, tight sands, and coal beds are anticipated to become an increasing portion of U.S. natural gas production. 5.
Is allergic rhinitis more frequent in young adults with extreme shyness? A preliminary survey. (1990)

Previous studies suggest that social anxiety, allergies and distressed affect may be interrelated in some persons. For example, extremely introverted patients experience a poorer course and outcome of allergies as well as greater degrees of distressed affect such as depression and anxiety than do extraverts. Patients with affective disorders have a higher prevalence of atopic allergy than the general population; families of patients with panic disorder and major depression have the highest frequency of shy children. Preliminary investigation also indicate that behaviorally inhibited Caucasian children (initially shy and cautions in unfamiliar situations) and their families have more allergies, especially hay fever, than do uninhibited, socially outgoing children. The present survey evaluated the frequency of self-reported shyness. The most introverted subjects had significantly higher scores on self reports of depression, fearfulness, and fatigue, as well as a higher prevalence of hay fever. The data support the possibility of a distinct subgroup of shy individuals with concomitant vulnerability to specific allergies and affective disorders.
Unilateral pedicle screw instrumentation for minimally invasive transforaminal lumbar interbody fusion (2006)

The use of unilateral percutaneous pedicle screw instrumentation for the minimally invasive TLIF procedure provides excellent clinical results and is an option in selected patients.