gebhart/patrepeval huggingface dataset:
Abstract A77: PVT1 exon 9 overexpression as a potential biomarker of prostate cancer in black men (2015)

Abstract Prostate cancer (PC) is disproportionately aggressive in Black men and is associated with single nucleotide polymorphisms around regions 2 and 3 of the 8q24 human chromosomal region. Variants of this region interact with the non-protein coding gene locus, PVT1, in PC. And, PVT1 is overexpressed in PC. The PVT1 gene locus has at least 12 exons that make separate transcripts. It is possible that these transcripts may have different functions. However, the role of PVT1 transcripts in PC is unknown. Our aim is to determine if PVT1 transcripts play a role in aggressiveness and racial disparity in PC. We used a panel of five PC cell lines: PC-3 (from a White man with aggressive androgen-independent PC); MDA PCa 2b (from a Black man with aggressive androgen-dependent PC (ADPC)); RWPE-1 (epithelial prostate cells from normal prostate of a White man); WPE1-NA22 (tumorigenic cells derived from RWPE-1 cells from a White man, tumors are ADPC and indolent), and VCaP (from a White man with ADPC). Ribonucleic acid (RNA) extraction, complimentary deoxyribonucleic acid (cDNA) synthesis, and quantitative polymerase chain reaction (qPCR) were performed to evaluate expression of all twelve PVT1 exons. Each qPCR was performed in quadruplicates. Four separate qPCR experiments were performed. Expression of PVT1 exons was inconsistent except for exon 9. There was no significant difference in exon 9 expression between RWPE1, WPE1-NA22, PC-3, and VCaP cells derived from White men. However, exon 9 expression in the MDA PCa 2b cell line derived from a Black man was significantly higher than in the other four cell lines by at least 61%. Consequently, we observed differential expression of exon 9 of PVT1 in a manner that suggests that exon 9 may be associated with PC in Black men. These data provide a basis for further examining the function and mechanisms of action of PVT1 exon 9 in PC in Black men. Citation Format: Olorunseun O. Ogunwobi, Adeodat Ilboudo. PVT1 exon 9 overexpression as a potential biomarker of prostate cancer in black men. [abstract]. In: Proceedings of the Seventh AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 9-12, 2014; San Antonio, TX. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2015;24(10 Suppl):Abstract nr A77.
Capillary Electrophoresis–Electrospray Ionization-Mass Spectrometry (CE–ESI-MS)-Based Metabolomics (2010)

Metabolomics is a rapidly emerging field of functional genomics research whose aim is the comprehensive analysis of low molecular weight metabolites in a biological sample. Capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS) represents a promising hyphenated microseparation platform in metabolomics, since a majority of primary metabolites are intrinsically polar. CE-ESI-MS offers a convenient format for the separation of complex mixtures of cationic, anionic, and/or zwitterionic metabolites, as well as their isobaric/isomeric ions without complicated sample handling. Moreover, online sample preconcentration with desalting is readily integrated during separation prior to ionization, where the migration behavior and ionization response of metabolites can be predicted based on their fundamental physicochemical properties. Herein, we describe recent developments in CE-ESI-MS with emphasis on practical protocols necessary for realizing reliable analyses as applied to targeted metabolite profiling and untargeted metabolomic studies in various biological samples.
Nanocrystalline Diamond Electrodes: Enabling electrochemical microsensing applications with high reliability and stability (2016)

THE DIAMOND (D) IS ONE OF the most precious materials in the world with unmatched physical and chemical properties, such as hardness, extreme chemical stability, high thermal conductivity, the highest acoustic velocity of any material, an extremely low friction coefficient when smooth, and nearly unmatched biocompatibility [1]. The carbon (C) atoms in Ds are tetrahedrally coordinated, i.e., each C atom is bonded to four others in the D lattice. This bonding is referred to as <i>sp</i> <sup>3</sup> bonding, and the strength and configuration of these bonds provide Ds with these unmatched fundamental properties and characteristics. Realizing these properties of the D in a C-based film that can easily be integrated into functional engineering systems and deployed in many applications has been a challenge for several decades. This is of primary concern in microelectronics, sensing, and hard-coating applications.
Leucine 7 to Proline 7 Polymorphism in the Neuropeptide Y Gene Is Associated with Enhanced Carotid Atherosclerosis in Elderly Patients with Type 2 Diabetes and Control Subjects<sup>1</sup> (2000)

We have recently demonstrated that subjects having Pro7 in the signal peptide ofneuropeptide Y (NPY) have higher serum cholesterol and apolipoprotein B levels than individuals with wild-type (Leu7Leu7) signal peptide sequence. We investigated the association of Leu7Pro polymorphism with common carotid intima media thickness (IMT) assessed by ultrasonograph in patients with type 2 diabetes (n = 81; 41 men and 40 women; mean age, 67.1 yr) and nondiabetic subjects (n = 105; 48 men and 57 women; mean age, 65.5 yr) and genotyped for the Leu7Pro polymorphism in prepro-NPY. The frequency of Pro7 in prepro-NPY was 9.9% (8 of 81) in diabetic patients and 14.3% (15 of 105) in control subjects (P = 0.360). The mean common carotid IMT was 1.04 +/- 0.02 mm in nondiabetic subjects without the Leu7Pro polymorphism and 1.14 +/- 0.04 mm in nondiabetic subjects with in (P = 0.156) and 1:18 +/- 0.03 and 1.58 +/- 0.21mm in diabetic patients without and with the Leu7Pro polymorphism (P = 0.004), respectively. In the analysis of covariance of the entire group, the mean common carotid IMT was independently associated with the Leu7Pro polymorphism (F = 5.165; P = 0.024) after adjustment for known risk factors. Thus, the presence of the Pro7 substitution in the prepro-NPY associates with increased carotid atherosclerosis.
Anatomy-Correlated Breast Imaging and Visual Grading Analysis Using Quantitative Transmission Ultrasound<i>™</i> (2016)

<i>Objectives</i>. This study presents correlations between cross-sectional anatomy of human female breasts and Quantitative Transmission (QT) Ultrasound, does discriminate classifier analysis to validate the speed of sound correlations, and does a visual grading analysis comparing QT Ultrasound with mammography. <i>Materials and Methods</i>. Human cadaver breasts were imaged using QT Ultrasound, sectioned, and photographed. Biopsies confirmed microanatomy and areas were correlated with QT Ultrasound images. Measurements were taken in live subjects from QT Ultrasound images and values of speed of sound for each identified anatomical structure were plotted. Finally, a visual grading analysis was performed on images to determine whether radiologists' confidence in identifying breast structures with mammography (XRM) is comparable to QT Ultrasound. <i>Results</i>. QT Ultrasound identified all major anatomical features of the breast, and speed of sound calculations showed specific values for different breast tissues. Using linear discriminant analysis overall accuracy is 91.4%. Using visual grading analysis readers scored the image quality on QT Ultrasound as better than on XRM in 69%-90% of breasts for specific tissues. <i>Conclusions</i>. QT Ultrasound provides accurate anatomic information and high tissue specificity using speed of sound information. Quantitative Transmission Ultrasound can distinguish different types of breast tissue with high resolution and accuracy.
Development and characterization of a cell line for large‐scale, serum‐free production of recombinant adeno‐associated viral vectors (2004)

AAV producer cell lines can be readily scaled to meet the needs of clinical trials. One 500 L bioreactor of these producer cells can produce the equivalent of 2500 high capacity roller bottles or 25 000 T-175 tissue culture flasks.
Extracting Interactions from Molecular Pathways (2017)

Health and life sciences' research fields make an intensive use of graphical information to represent complex relations between biological entities, called molecular pathways. Interpretation of molecular pathway diagrams requires domain-specific knowledge to remove ambiguity. We propose a fully automatic method that detects entities and extracts their relations from diagrams. It uses image analysis and a domain-specific cognitive model and automatically produces a structured textual version of the content. Results on an annotated dataset show precision of 0.99 and recall of up to 0.85 for the detection of molecular entities and interactions.
Control and dynamics of a flexible spacecraft during stationkeeping maneuvers (1991)

A case study of a spacecraft having flexible solar arrays is presented. A stationkeeping attitude control mode using both earth and rate gyro reference signals and a flexible vehicle dynamics modeling and implementation is discussed. The control system is designed to achieve both pointing accuracy and structural mode stability during stationkeeping maneuvers. Reduction of structural mode interactions over the entire mode duration is presented. The control mode using a discrete time observer structure is described to show the convergence of the spacecraft attitude transients during Delta-V thrusting maneuvers without preloading thrusting bias to the onboard control processor. The simulation performance using the three axis, body stabilized nonlinear dynamics is provided. The details of a five body dynamics model are discussed. The spacecraft is modeled as a central rigid body having cantilevered flexible antennas, a pair of flexible articulated solar arrays, and to gimballed momentum wheels. The vehicle is free to undergo unrestricted rotations and translations relative to inertial space. A direct implementation of the equations of motion is compared to an indirect implementation that uses a symbolic manipulation software to generate rigid body equations.
Optical-RF frequency stability transformer (2011)

An optical technique based on stability transfer among modes of a monolithic optical microresonator is proposed for long term frequency stabilization of a radio frequency (RF) oscillator. We show that locking the frequency difference of two microresonator modes with dissimilar sensitivity to an applied forcing function to a master RF oscillator improves the long term stability of a slave RF oscillator locked to the frequency difference of another pair of modes with nearly identical sensitivity to the same forcing function. For instance, the stability of a 10 MHz master oscillator with Allan deviation of 10(-7) at 10(3) s can be improved and transferred to a slave oscillator with identical free running stability performance, so that the resultant Allan deviation of the slave oscillator becomes equal to 10(-13) at 10(3) s. The suggested method does not require absolute frequency references.
<title>Assessing the enhancement of image sharpness</title> (2006)

This study investigated four different image sharpness enhancement methods. Two methods applied standard sharpening filters (Sharpen and Sharpen More) in PhotoShop and the other two were based on adjustment of the image power spectrum using the human visual contrast sensitivity function. A psychophysical experiment was conducted with 25 observers, the results of which are presented and discussed. Five conclusions are drawn from this experiment: (1) Performance of the sharpening methods; (2) Image dependence; (3) Influence of two different colour spaces on sharpness manipulation; (4) Correlation between perceived image sharpness and image preference; and (5) Effect of image sharpness enhancement on the image power spectrum.
Cold cathode field emitter array on a quadrupole mass spectrometer: Route to miniaturization (1999)

We have improved the quadrupole mass spectrometer by substituting the conventional hot filament electron source by a field emitter array (FEA). Elimination of the hot filament avoids a number of common problems, including thermal cracking of delicate molecules, outgassing of the filament itself and nearby components, high power requirements for the filament, large size, stray light, stray magnetic fields, contamination by thoria and tungsten, and a long warm-up time. The advantages are clearest for portable applications where power requirements dominate. Here, the power savings are not just in eliminating the filament supply, but more important in reducing the largest component of the system, the vacuum pump. This comes about because the filament is the primary gas load and because chemical reactions taking place on it require fast pumping to keep the products from interfering with the spectra. Comparison between hot filament and cold cathode FEA ionization is made using a quadrupole mass spectrometer fitted with both electron sources, independently controlled. The FEA advantage is strongest when the ultrahigh vacuum system is throttled to a low pumping speed, mimicking a portable system with a small pump. FEAs also enable miniaturization and a corresponding decrease in pump size. Moreover, with miniaturization, shorter mean free paths and consequently higher working pressures can be tolerated further decreasing pump requirements.
All-systolic non-ECG-gated myocardial perfusion MRI: Feasibility of multi-slice continuous first-pass imaging (2015)

The presented methods and results demonstrate feasibility of the proposed approach for high-resolution non-ECG-gated FPP imaging of 3 myocardial slices at the same systolic phase, and indicate its potential for achieving desirable image quality (high CNR and no dark-rim artifacts).
A soft-switched high frequency converter for wide voltage and power ranges (2016)

Power converters requiring wide voltage and power ranges (including power factor correction converters) are difficult to effectively implement with soft switching at high frequencies, limiting their density and/or efficiency. We propose a soft-switched converter that can operate at HF (3-30MHz) across wide input voltage and power ranges. A prototype converter experimentally achieves zero voltage switching in the MHz regime and outputs 400Vdc across input voltages of 10-400Vdc and output powers of 100-400W. This converter will permit further miniaturization of grid-interface and other converters while still maintaining high efficiency.
Direct Catalytic Anti-Markovnikov Addition of Carboxylic Acids to Alkenes (2013)

A direct catalytic anti-Markovnikov addition of carboxylic acids to alkenes is reported. The catalyst system is comprised of the Fukuzumi acridinium photooxidant (1) and a substoichiometric quantity of a hydrogen-atom donor. Oxidizable olefins, such as styrenes, trisubstituted aliphatic alkenes, and enamides, can be employed along with a variety of carboxylic acids to afford the anti-Markovnikov addition adducts exclusively. A deuterium-labeling experiment lends insight to the potential mechanism.
Real-Time Data-Acquisition Platform for Pulsed Measurements (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Sergey V. Polyakov, Alan Migdall, Sae Woo Nam; Real‐Time Data‐Acquisition Platform for Pulsed Measurements. AIP Conference Proceedings 28 March 2011; 1327 (1): 505–519. https://doi.org/10.1063/1.3567482 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach (2005)

A novel series of 3,5-diaryl-oxadiazoles was identified as apoptosis-inducing agents through our cell and chemical genetics-based screening assay for compounds that induce apoptosis using a chemical genetics approach. Several analogues from this series including MX-74420 and MX-126374 were further characterized. MX-126374, a lead compound from this series, was shown to induce apoptosis and inhibit cell growth selectively in tumor cells. To elucidate the mechanism(s) by which this class of compounds alters the signal transduction pathway that ultimately leads to apoptosis, expression profiling using the Affymetrix Gene Chip array technology was done along with other molecular and biochemical analyses. Interestingly, we have identified several key genes (cyclin D1, transforming growth factor-beta1, p21, and insulin-like growth factor-BP3) that are altered in the presence of this compound, leading to characterization of the pathway for activation of apoptosis. MX-126374 also showed significant inhibition of tumor growth as a single agent and in combination with paclitaxel in murine tumor models. Using photoaffinity labeling, tail-interacting protein 47, an insulin-like growth factor-II receptor binding protein, was identified as the molecular target. Further studies indicated that down-regulation of tail-interacting protein 47 in cancer cells by small interfering RNA shows a similar pathway profile as compound treatment. These data suggest that 3,5-diaryl-oxadiazoles may be a new class of anticancer drugs that are tumor-selective and further support the discovery of novel drugs and drug targets using chemical genetic approaches.
Identification of new Saccharomyces cerevisiae variants of the MET2 and SKP2 genes controlling the sulfur assimilation pathway and the production of undesirable sulfur compounds during alcoholic fermentation (2015)

This study provides new insight into the regulation of sulfur metabolism in wine yeasts and identifies variants of MET2 and SKP2 genes, that control the activity of both branches of the sulfur amino acid synthesis pathway and modulate sulfite/sulfide production and other related phenotypes. These results provide novel targets for the improvement of wine yeast strains.
Accurate measurement of the external quantum efficiency of multi-junction solar cells (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Li and Y. Zhang, "Accurate measurement of the external quantum efficiency of multi-junction solar cells," in Conference on Lasers and Electro-Optics 2012, OSA Technical Digest (online) (Optical Society of America, 2012), paper CF1J.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Stable Cyclic (Alkyl)(amino)carbenes as Rigid or Flexible, Bulky, Electron‐Rich Ligands for Transition‐Metal Catalysts: A Quaternary Carbon Atom Makes the Difference. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
The effects of phenylpropanolamine on dietary intake, physical activity, and body weight after smoking cessation (1990)

This investigation evaluated the effect of phenylpropanolamine on the weight gain associated with 2 weeks of abstinence from smoking. Subjects were 57 adult female cigarette smokers who were randomly assigned, in a double-blind procedure, to chew gum with phenylpropanolamine or placebo gum, or to chew no gum. After a baseline assessment, subjects were paid to quit smoking for a period of 2 weeks. Forty-one (72%) of the 57 subjects were successful in quitting smoking for the 2-week period. Results indicated that, relative to the other two conditions, abstinent subjects receiving phenylpropanolamine gained 1.5 to 1.9 pounds less weight (p less than 0.05). In addition, abstinence rates were higher (p less than 0.03) and dietary intake lower for subjects receiving phenylpropanolamine (p less than 0.05) relative to the other two conditions. No changes in physical activity were observed. It is concluded that phenylpropanolamine may help reduce weight gain associated with smoking abstinence and in this way may enhance smoking cessation efforts in certain individuals.
Computer design of super-orthogonal space-time trellis codes (2007)

Super-orthogonal space-time trellis codes (SOSTTCs) designed by hand can significantly improve the performance of space-time trellis codes. This paper introduces a new representation of SOSTTCs based on a generator matrix that allows a systematic and exhaustive search of all possible codes. This will verify that some of the known codes are optimal, and provides a means to easily implement encoders and decoders with a large number of states without relying on a graphical representation. New codes with up to 256 states that outperform previously known codes are presented
Fast semi-automatic target initialization based on visual saliency for airborne thermal imagery (2015)

In this study, a semi-automatic target initialization algorithm is introduced based on a recently proposed visual saliency approach. First, a center-surround difference based initial window selection is utilized around the input point coordinate provided by the user, in order to select the window which is most likely to contain the actual target and background satisfying piecewise connectivity. Then, a recently proposed visual saliency algorithm is exploited in order to detect the bounding box encapsulating the most salient part of the object. The experiments support that the saliency based tracking window initialization is capable of handling marking errors, i.e. erroneous user inputs, and boosts the performance of several tracking algorithms in terms of the number of frames in which successful tracking is achieved, when compared with several fixed window size initializations.
Classification of Human Activities Using Variation in Impedance of Single On-Body Antenna (2016)

We propose to use the variation in input impedance of a single on-body antenna to classify human activities. The reflection coefficients of a single on-body antenna are shown to exhibit unique time-varying features for various daily activities. Employing seven human subjects, six different activities are measured by two antenna placements at three operating frequencies. A dynamic time-warping algorithm is introduced to classify the human activities. We find that the classification accuracy can be as high as 98% when the antenna is placed on the chest and operates at 433 MHz. The classification accuracy in terms of the time-window size is also presented and discussed.
Correction: Synthesis, structural characterization, electrochemical behavior and anticancer activity of gold(<scp>iii</scp>) complexes of <i>meso</i>-1,2-di(1-naphthyl)-1,2-diaminoethane and tetraphenylporphyrin (2020)

Correction for ‘Synthesis, structural characterization, electrochemical behavior and anticancer activity of gold(<sc>iii</sc>) complexes of <italic>meso</italic>-1,2-di(1-naphthyl)-1,2-diaminoethane and tetraphenylporphyrin’ by Muhammad Altaf <italic>et al.</italic>, <italic>New J. Chem.</italic>, 2016, <bold>40</bold>, 8288–8295, DOI: 10.1039/C6NJ00692B.
High-Density Lipoprotein Cholesterol (2007)

HDL is an emerging target for atherosclerotic stroke treatment with the potential to dramatically impact the care of stroke patients.