gebhart/patrepeval huggingface dataset:
Microsoft® windows vista® on demand, second edition (2008)

Microsoft Windows Vista On Demand, Second EditionFOR THOSE WHO WOULD RATHER BE SHOWN HOW THAN TOLD HOWSEE HOW TO· Master the Windows Vista user experience, including Windows Aero· Manage files and information using Windows Vista programs and Sidebar gadgets· Create your own movies, slides shows, and DVDs· Rip, manage, and play digital music and videos· Protect your computer from Internet or network intruders· Explore the Internet, send e-mail and instant message, and publish calendars on the Web· Customize, fine-tune, and administer Windows Vista· Set up multiple users and parental controls· Perform Instant Searches to quickly find files and programs· Prepare for the Microsoft Certified Application Specialist examOn the WebThis book uses real-world examples to give you a context in which to use the tasks. This book also includes workshops to help you put together individual tasks into projects. The Windows Vista example files that you need for project tasks are available at www.perspection.com.Perspection has written and produced books on a variety of computer softwarei¾including Microsoft Office 2007 and 2003, Microsoft Windows Vista and XP, Microsoft Expression Web, Apple Mac OS X Leopard, Adobe Photoshop CS3 and CS2, Adobe Flash CS3 and 8, and Adobe Dreamweaver CS3. In 1991, after working for Apple Computer and Microsoft, Steve Johnson founded Perspection, Inc. Perspection is committed to providing information and training to help people use software more effectively. Perspection has written more than 80 computer books, and sold more than 5 million copies.Includes MCAS Exam Objectives!This courseware meets the objectives for the Microsoft Certified Application Specialist (MCAS). Upon completion of this courseware, you may be prepared to take the exam for MCAS qualification. To learn more about becoming a Microsoft Certified Application Specialist, visit www.microsoft.com.
Derivation of Gaussian Distribution in Physics and Life Energies (2008)

There are three different statistical distributions in physics, Maxwell-Boltzman distribution, Bose-Ein-stein distribution, and Fermi-Dirac distribution. However it is well known that physical measurement erors are followingthe Gaussian distribution. And also human behaviors are statistically following to the Gaussian distribution. There arefour kinds of rotational electromagnetic waves, leftwise positive, leftwise negative, rightwise positive, rightwise neg-ative. From them two kinds of mind forces are generated, explosive and implosive. The square of the potential energiesproduces the probability density function, which is the Gaussian statistical distribution. All physical measurement errorsand human behaviors are following to this Gaussian distribution.
An automated method for neuronal spike source identification (2004)

Analysis of microelectrode recordings (MER) of extracellular neuronal activity has gained increasing interest due to potential improvements to surgical techniques involving ablation or placement of deep brain stimulators, as is common in the treatment of Parkinson's disease. Critical to these procedures is the identification of different brain structures such as the globus pallidus internus (GPI). Evidence suggests that the spike trains from individual neurons contain enough information to identify the brain structure in which they are located For the work reported here, spike train data gathered during surgical procedure from multiple patients is used. Using a moving window sampling approach, a novel feature extraction method for spike trains was developed. This method is then used in combination with a support vector classification algorithm. Results strongly indicate that the sampling methods reported here are able to extract the necessary information for highly accurate spike source identification.
Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast cancer patients (2013)

The reduction of ADCC in patients as compared to healthy controls calls for adjuvant strategies, such as immune-enhancing agents, to improve the activity of trastuzumab. However, efficacy of trastuzumab-specific ADCC and ADCP appears not to be affected by treatment duration, disease progression or concomitant chemotherapy. This finding supports the application of trastuzumab at any stage of the disease.
Functional Characterization of the Canine Heme-Regulated eIF2<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi></mml:math>Kinase: Regulation of Protein Synthesis (2009)

The heme-regulated inhibitor (HRI) negatively regulates protein synthesis by phosphorylating eukaryotic initiation factor-2alpha (eIF2alpha) thereby inhibiting protein translation. The importance of HRI in regulating hemoglobin synthesis in erythroid cells makes it an attractive molecular target in need of further characterization. In this work, we have cloned and expressed the canine form of the HRI kinase. The canine nucleotide sequence has 86%, 82%, and 81% identity to the human, mouse, and rat HRI, respectively. It was noted that an isoleucine residue in the ATP binding site of human, rat, and mouse HRI is replaced by a valine in the canine kinase. The expression of canine HRI protein by in vitro translation using wheat germ lysate or in Sf9 cells using a baculovirus expression system was increased by the addition of hemin. Following purification, the canine protein was found to be 72 kD and showed kinase activity determined by its ability to phosphorylate a synthetic peptide substrate. Quercetin, a kinase inhibitor known to inhibit mouse and human HRI, inhibits canine HRI in a concentration-dependent manner. Additionally, quercetin is able to increase de novo protein synthesis in canine reticulocytes. We conclude that the canine is a suitable model species for studying the role of HRI in erythropoiesis.
Ball‐Milling Modification of Single‐Walled Carbon Nanotubes: Purification, Cutting, and Functionalization (2011)

Single-walled carbon nanotubes (SWNTs) can be successfully cut with relatively homogeneous sizes using a planetary mill. The optimized conditions produce highly dispersible SWNTs that can be efficiently functionalized in a variety of synthetic ways. As clearly shown by Raman spectroscopy, the milling/cutting procedure compares very favorably with the most common way of purifying SWNTs, namely, treatment with strong oxidizing acids. Moreover a similar milling process can be used to functionalize and cut pristine SWNTs by one-step nitrene chemistry.
Targeted Deletion of mNth1 Reveals a Novel DNA Repair Enzyme Activity (2002)

DNA N-glycosylase/AP (apurinic/apyrimidinic) lyase enzymes of the endonuclease III family (nth in Escherichia coli and Nth1 in mammalian organisms) initiate DNA base excision repair of oxidized ring saturated pyrimidine residues. We generated a null mouse (mNth1(-/-)) by gene targeting. After almost 2 years, such mice exhibited no overt abnormalities. Tissues of mNth1(-/-) mice contained an enzymatic activity which cleaved DNA at sites of oxidized thymine residues (thymine glycol [Tg]). The activity was greater when Tg was paired with G than with A. This is in contrast to Nth1, which is more active against Tg:A pairs than Tg:G pairs. We suggest that there is a back-up mammalian repair activity which attacks Tg:G pairs with much greater efficiency than Tg:A pairs. The significance of this activity may relate to repair of oxidized 5-methyl cytosine residues (5meCyt). It was shown previously (S. Zuo, R. J. Boorstein, and G. W. Teebor, Nucleic Acids Res. 23:3239-3243, 1995) that both ionizing radiation and chemical oxidation yielded Tg from 5meCyt residues in DNA. Thus, this previously undescribed, and hence novel, back-up enzyme activity may function to repair oxidized 5meCyt residues in DNA while also being sufficient to compensate for the loss of Nth1 in the mutant mice, thereby explaining the noninformative phenotype.
Fully automatic image colorization based on Convolutional Neural Network (2016)

This paper deals with automatic image colorization. This is a very difficult task, since it is an ill-posed problem that usually requires user intervention to achieve high quality. A fully automatic approach is proposed that is able to produce realistic colorization of an input grayscale image. Motivated by the recent success of deep learning techniques in image processing, we propose a feed-forward, two-stage architecture based on Convolutional Neural Network that predicts the U and V color channels. Unlike most of the previous works, this paper presents a fully automatic colorization which is able to produce high-quality and realistic colorization even of complex scenes. Comprehensive experiments and qualitative and quantitative evaluations were conducted on the images of SUN database and on other images. We have found that Quaternion Structural Similarity (QSSIM) gives in some degree a good base for quantitative evaluation, that is why we chose QSSIM as an index-number for the quality of colorization.
Applications of amorphous alloys (1978)

High saturation magnetization, low loss, and high permeability amorphous alloys are discussed. Applications which have been described in the literature and make use of some of the unique characteristics of these amorphous alloys are reviewed.
Composite Acoustic Medium with Simultaneously Negative Density and Modulus (2010)

We fabricated an acoustic composite structure consisting of a periodic array of interspaced membranes and side holes. Experimental data on the transmission, effective density, and phase velocity are presented. The system exhibits two critical frequencies, omega{SH} and omega{c}. Our metamaterial is double negative and transparent for frequencies lower than omega{SH}. For the frequencies omega{SH}<omega<omega{c}, the medium is opaque and only the density is negative. For the frequencies above omega{c}, the system is double positive and transparent. The present medium exhibits a very wide double negative spectral range that opens the possibility of the application of metamaterials for "white lights."
Preparation of Benzylic α,α-Difluoronitriles, -tetrazoles, and -sulfonates via Electrophilic Fluorination (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTPreparation of Benzylic α,α-Difluoronitriles, -tetrazoles, and -sulfonates via Electrophilic FluorinationChristopher C. Kotoris, Mei-Jin Chen, and Scott D. TaylorView Author Information Department of Chemistry, University of Toronto, Mississauga Campus, 3359 Mississauga Road North, Mississauga, Ontario, Canada L5L 1C6 Cite this: J. Org. Chem. 1998, 63, 22, 8052–8057Publication Date (Web):October 13, 1998Publication History Received17 June 1998Published online13 October 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/jo981163xhttps://doi.org/10.1021/jo981163xbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1360Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information SUBJECTS:Halogenation,Inhibitors,Organic compounds,Peptides and proteins,Reaction products Get e-Alerts
Type 2 diabetes mellitus and testosterone: a meta-analysis study (2010)

Several studies suggest that type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. The aim of the present study was to analyse systematically the relationship between androgen levels and T2DM by reviewing and meta-analysing available prospective and cross-sectional studies. In addition, a specific meta-analysis on the metabolic effects of TRT in available randomized clinical trials (RCTs) was performed. An extensive Medline search was performed including the following words: 'testosterone', 'type 2 diabetes mellitus' and 'males'. Of 742 retrieved articles, 37 were included in the study. In particular 28, 5 and 3 were cross-sectional, longitudinal and interventional studies, respectively. A further unpublished RCT was retrieved from http://www.clinicaltrials.gov. T2DM patients showed significantly lower testosterone plasma levels in comparison with non-diabetic individuals. Similar results were obtained when T2DM subjects with and without erectile dysfunction were analysed separately. Meta-regression analysis demonstrated that ageing reduced, while obesity increased, these differences. However, in a multiple regression model, after adjusting for age and body mass index (BMI), T2DM was still associated with lower total testosterone (TT) levels (adjusted r = -0.568; p < 0.0001). Analysis of longitudinal studies demonstrated that baseline TT was significantly lower among patients with incident diabetes in comparison with controls (HR = -2.08[-3.57;-0.59]; p < 0.001). Combining the results of RCTs, TRT was associated with a significant reduction in fasting plasma glucose, HbA1c, fat mass and triglycerides. Conversely, no significant difference was observed for total and high-density lipoprotein cholesterol, blood pressure and BMI. The meta-analysis of the available cross-sectional data suggests that T2DM can be considered independently associated with male hypogonadism. Although only few RCTs have been reported, TRT seems to improve glycometabolic control as well as fat mass in T2DM subjects.
Flare impact on the intrafield CD control for sub-0.25-μm patterning (1999)

The aim of this paper is to investigate the intrafield flare distribution and its link with the intrafield CD variation for various ASML lithographic tools. Flare is measured as the required dose to clear a 100micrometers -large positive resist pattern and comparing it with dose-to-clear Eo. The reticle layout used is compared of a repetitive cell which allows for 77 measurements within a single 22 X 22 mm<SUP>2</SUP> field. Experimental results show that in the field of a stepper, flare decreases almost linearly form center to edge. In the field of a scanner, the flare distribution result from the distribution inside the illumination slit which is ellipsoidal. Comparing the intrafield flare distribution to the intrafield CD uniformity , it appears that flare is responsible for a part of the across field CD variation. We will see in this paper how it is possible, using a method based on statistical considerations, to decorrelate both the contributions of mask CD errors and flare variation to the intrafield CD dispersion for dense lines and 1/3 for isolated lines. The intrafield flare variation is also found to contribute a lot to the signature of the CD uniformity and to the 3 sigma dispersion.
Moving towards Real-time Data-driven Quality Monitoring: A Case Study of Hard Disk Drives (2018)

Since its emergence, the cloud manufacturing concept has been transforming the manufacturing and remanufacturing industry into a big data and service-oriented environment. The aggressive push toward data collection in cloud-based and cyber-physical systems provides both challenges and opportunities for predictive analytics. One of the key applications of predictive analytics in such domains is predictive quality management that aims to fully exploit the potentials provided by the enormous data collected via cloud-based systems. As a case study, a data set of hard disk drives' Self-Monitoring, Analysis and Reporting Technology (SMART) attributes from a cloud-storage service provider has been analyzed to derive some insights about the challenges and opportunities of using product lifecycle data. An analysis of time-to-failure monitoring of hard disk drives in real-time has been carried out and the corresponding challenges have been discussed.
Selective macrolactonization using zeolite molecular sieves (1993)

T. Tatsumi, H. Sakashita and K. Asano, J. Chem. Soc., Chem. Commun., 1993, 1264 DOI: 10.1039/C39930001264
Secreted Gal-3BP is a novel promising target for non-internalizing Antibody–Drug Conjugates (2018)

Galectin-3-binding protein (Gal-3BP) has been identified as a cancer and metastasis-associated, secreted protein that is expressed by the large majority of cancers. The present study describes a special type of non-internalizing antibody-drug-conjugates that specifically target Gal-3BP. Here, we show that the humanized 1959 antibody, which specifically recognizes secreted Gal-3BP, selectively localized around tumor but not normal cells. A site specific disulfide linkage with thiol-maytansinoids to unpaired cysteine residues of 1959, resulting in a drug-antibody ratio of 2, yielded an ADC product, which cured A375m melanoma bearing mice. ADC products based on the non-internalizing 1959 antibody may be useful for the treatment of several human malignancies, as the cognate antigen is abundantly expressed and secreted by several cancers, while being present at low levels in most normal adult tissues.
Histidine‐rich glycoprotein exerts antibacterial activity (2006)

Histidine-rich glycoprotein (HRGP), an abundant heparin-binding protein found in plasma and thrombocytes, exerts antibacterial effects against Gram-positive bacteria (Enterococcus faecalis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). Fluorescence studies and electron microscopy to assess membrane permeation showed that HRGP induces lysis of E. faecalisbacteria in the presence of Zn2+ or at low pH. Heparin blocked binding of the protein to E. faecalis and abolished antibacterial activity. Furthermore, truncated HRGP, devoid of the heparin-binding and histidine-rich domain, was not antibacterial. It has previously been shown that peptides containing consensus heparin-binding sequences (Cardin and Weintraub motifs) are antibacterial. Thus, the peptide (GHHPH)4, derived from the histidine-rich region of HRGP and containing such a heparin-binding motif, was antibacterial for E. faecalis in the presence of Zn2+ or at low pH. The results show a previously undisclosed antibacterial activity of HRGP and suggest that the histidine-rich and heparin-binding domain of HRGP mediates the antibacterial activity of the protein.
Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway (2021)

Our data suggest the potential for TADIOS to be developed as a safe and effective therapeutics for the treatment of acute respiratory distress syndrome.
Prognostic and clinical relevance of pupillary responses, intracranial pressure monitoring, and brainstem auditory evoked potentials in comatose patients with acute supratentorial mass lesions (1993)

Pupillary abnormalities may serve as a reliable parameter, which may even be superior to brainstem auditory evoked potential testing and intracranial pressure monitoring for prediction of outcome in comatose individuals with supratentorial mass lesions. Brainstem auditory evoked potentials can be used to support the clinical relevance of abnormal pupillary status and increased intracranial pressure but are of no prognostic value. Increased intracranial pressure is associated with abnormalities in pupillary status and brainstem auditory evoked potentials. Examination for pupillary abnormalities in combination with intracranial pressure monitoring and brainstem auditory evoked potential testing seems to be a useful strategy in managing patients with supratentorial mass lesions in critical care units.
Fabrication of Porous Polymer Monoliths in Polymeric Microfluidic Chips as an Electrospray Emitter for Direct Coupling to Mass Spectrometry (2006)

Coupling of polymeric microfluidic devices to mass spectrometry is reported using porous polymer monoliths (PPM) as nanoelectrospray emitters. Lauryl acrylate-co-ethylene dimethacrylate porous polymer monolith was photopatterned for 5 mm at the end of the channel of microfluidic devices fabricated from three different polymeric substrate materials, including the following: poly(dimethylsiloxane) (PDMS), poly(methyl methacrylate) (PMMA), and cyclic olefin copolymer (COC). Spraying directly from the end of the chip removes any dead volume associated with inserted emitters or transfer lines, and the presence of multiple pathways in the PPM prevents the clogging of the channels, which is a common problem in conventional nanospray emitters. Spraying from a microfluidic channel having a PPM emitter produced a substantial increase in TIC stability and increased sensitivity by as much as 70x compared to spraying from an open end chip with no PPM. The performance of PPM emitter in COC, PMMA, and PDMS chips was compared in terms of stability and reproducibility of the electrospray. COC chips showed the highest reproducibility in terms of chip-to-chip performance, which can be attributed to the ease and reproducibility of the PPM formation due to the favorable optical and chemical properties of COC. We have further tested the performance of the COC chips by constant infusion of poly(propylene glycol) solution at organic content ranging from 10 to 90% methanol and at flow rates ranging from 50 to 1000 nL/min, showing optimum spraying conditions (RSD < 5%) at 50-70% organic content and at flow rates from 100 to 500 nL/min. The PPM sprayer was also used for protein preconcentration and desalting prior to mass spectrometric detection, and results were comparable with a chip spraying from an electrospray tip.
Fourth-order cascade SC ΣΔ modulators: a comparative study (1998)

Fourth-order cascade /spl Sigma//spl Delta/ modulators are very well suited for IC implementation using analog sampled-data circuits because of their robust, stable operation and their capability to achieve high resolution and wide bandwidth with moderate power consumption. However, their optimum realization requires careful consideration of their performance degradations due to the hardware nonidealities. This paper presents a comparative study of the influence of finite op-amp gain and capacitor mismatch on the performance of fourth-order cascade /spl Sigma//spl Delta/ modulators realized by means of switched-capacitor circuits. It considers single-bit and multibit quantizers and draws a number of comparative remarks validated by time-domain behavioral simulations.