gebhart/patrepeval huggingface dataset:
Applying Control-Value Theory and Unified Theory of Acceptance and Use of Technology to Explore Pre-service Teachers’ Academic Emotions and Learning Satisfaction (2021)

Academic emotions refer to the emotions related to achievement activities or outcomes. Academic emotions are directly related to learning performance and have been recognized as critical to learners' learning satisfaction and learning effectiveness in the online learning context. This study aimed to explore the relationship between academic emotions and learning satisfaction and their underlying mechanisms in massive open online courses (MOOCs) learning context using mediation models. This study adhered to the theoretical frameworks of the control-value theory (CVT) and the unified theory of acceptance and use of technology (UTAUT). Participants were 283 pre-service teachers who volunteered from a normal university in Southwestern China. Results revealed that: (a) academic emotions did not predict learning satisfaction; (b) learning interest and technology acceptance fully mediated the influence of academic emotions on learning satisfaction; (c) the four dimensions of technology acceptance did not mediate the relationship between academic emotions and learning satisfaction. This study integrated CVT and UTAUT models, and the results emphasized the importance of academic emotions and learning satisfaction in CVT and provision of additional support for UTAUT. Therefore, these findings have significant implications for improving the quality of MOOCs in the post-pandemic era.
Circadian Rhythm, Lifestyle and Health: A Narrative Review. (2018)

Although environmental factors are universal events which are unrelated to human control but affect human's body and circadian rhythm. Other factors are manageable by human to prevent disturbance of circadian rhythm making physical disorders.
Lifetime Estimation Using Only Failure Information From Warranty Database (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Knowledge about product lifetime obtained from actual usage (field data) is of great importance to manufacturers who want to get information about the true reliability of their products. Warranty data are frequently used to estimate reliability characteristics because such databases are automatically generated and updated at no additional cost from repair claims during warranty coverage. For engineering purposes, usage time (e.g., mileage) is more relevant, and lifetime parameters measured in usage time is an integral part of reliability analysis using warranty data. Usually, warranty data consist of only failure information. Censored data (e.g., mileage of non-failure automobiles) are not obtainable, of which usage time distributions are different from those of failed ones. Effective usage-based estimation thus requires supplementary information about usage accumulation for non-failure units such as follow-up studies, or a usage time distribution which includes both failure, and non-failure products. However, sometimes usage-based data for non-failed units are expensive and difficult to obtain. Thus, the unavailability of the usage time of censored units makes it difficult to estimate the usage-based lifetime distribution of products. This paper deals with that problem, and discusses how to estimate the lifetime distribution using warranty data which consist of only failure information. The practical consequence of this finding is that supplemental information is not needed to obtain correct estimates of the lifetime parameters. </para>
Supramolecular Recognition Allows Remote, Site‐Selective C−H Oxidation of Methylenic Sites in Linear Amines (2017)

Site-selective C-H functionalization of aliphatic alkyl chains is a longstanding challenge in oxidation catalysis, given the comparable relative reactivity of the different methylenes. A supramolecular, bioinspired approach is described to address this challenge. A Mn complex able to catalyze C(sp<sup>3</sup> )-H hydroxylation with H<sub>2</sub> O<sub>2</sub> is equipped with 18-benzocrown-6 ether receptors that bind ammonium substrates via hydrogen bonding. Reversible pre-association of protonated primary aliphatic amines with the crown ether selectively exposes remote positions (C8 and C9) to the oxidizing unit, resulting in a site-selective oxidation. Remarkably, such control of selectivity retains its efficiency for a whole series of linear amines, overriding the intrinsic reactivity of C-H bonds, no matter the chain length.
Psychotic Disorders (2018)

Psychosis is a syndrome embedded in several disorders, including schizophrenia and bipolar disorder with psychotic features. Dopamine and glutamate are implicated in the pathophysiology of psychotic symptoms. Psychosocial treatments supplement pharmacologic therapy.
Determination of absolute bond strength from hydroxyl groups at oxidized aluminum-epoxy interfaces by angle beam ultrasonic spectroscopy (2004)

The hydrogen bonding (H-bond) contribution to the adhesive strength of oxidized aluminum-epoxy interfaces is calculated from the Morse potential for the interaction of hydroxyl groups formed on the Al2O3 surface with epoxy receptors. A strength parameter called the normal spring constant flux KN is defined and calculated to be 3.8×1017Nm−3, corresponding to a tensile strength of 26MPa, for values of the H-bond parameters and bond densities typical of moderate strength epoxies. The KN value is in very good agreement with values determined experimentally from an inversion of ultrasonic spectral data [A. I. Laverntyev and S. I. Rokhlin, J. Appl. Phys. 76, 4643 (1994); J. Acoust. Soc. Am. 102, 3467 (1997)]. It is also in agreement with the value KN=3.6×1017Nm−3 obtained by a reinterpretation of the periodic crack model [F. J. Margetan et al., J. Nondestr. Eval. 7, 131 (1988)] when applied to adhesive interfaces. The agreement between theory and experiment establishes KN as a quantitative nondestructive measure of adhesive strength. The relationship between the normal and transverse (shear) spring constant fluxes is derived and the effects of thermal fluctuations are addressed.
Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones (1995)

A key event in bone resorption is the recruitment of osteoclasts to future resorption sites. We follow here the migration of preosteoclasts from the periosteum to the developing marrow cavity of fetal mouse metatarsals in culture, and investigate the role of proteinases and demineralization in this migration. Our approach consisted in testing inhibitors of proteinases and demineralization on the migration kinetics. Migration was monitored by histomorphometry and the (pre)osteoclasts were identified by their tartrate resistant acid phosphatase (TRAP) activity. At the time of explantation, TRAP+ cells (all mononucleated) are detected only in the periosteum, and the core of the diaphysis (future marrow cavity) consist of calcified cartilage. Upon culture, TRAP+ cells (differentiating progressively into multinucleated osteoclasts) migrate through a seam of osteoid and a very thin and discontinuous layer of mineral, invade the calcified cartilage and transform it into a "marrow' cavity; despite the passage of maturing osteoclasts, the osteoid develops into a bone collar. The migration of TRAP+ cells is completely prevented by matrix metalloproteinase (MMP) inhibitors, but not by a cysteine proteinase inhibitor, an inhibitor of carbonic anhydrase, or a bisphosphonate. The latter three drugs inhibit, however, the resorptive activity of mature osteoclasts at least as efficiently as do the MMP inhibitors, as assessed in cultures of calvariae and radii. Furthermore, in situ hybridizations reveal the expression of 2 MMPs, gelatinase B (MMP-9 or 92 kDa type IV collagenase) in (pre)osteoclasts, and interstitial collagenase (MMP-13) in hypertrophic chondrocytes. It is concluded that only MMPs appear obligatory for the migration of (pre)osteoclasts, and that this role is distinct from the one MMPs may play in the subosteoclastic resorption compartment. We propose that this new role of MMPs is a major component of the mechanism that determines where and when the osteoclasts will attack the bone.
Mitigation of NBTI induced performance degradation in on-chip digital LDOs (2018)

On-chip digital low-dropout voltage regulators (LDOs) have recently gained impetus and drawn significant attention for integration within both mobile devices and micro-processors. Although the benefits of easy integration and fast response speed surpass analog LDOs and other voltage regulator types, NBTI induced performance degradation is typically overlooked. The conventional bi-directional shift register based controller can even exacerbate the degradation, which has been demonstrated theoretically and through practical applications. In this paper, a novel uni-directional shift register is proposed to evenly distribute the electrical stress and mitigate the NBTI effects under arbitrary load conditions with nearly no extra power and area overhead. The benefits of the proposed design as well as reliability aware design considerations are explored and highlighted through simulation of an IBM POWER8 like processor under several benchmark applications. It is demonstrated that the proposed NBTI-aware design can achieve up to 43.2% performance improvement as compared to a conventional one.
Ultrafast all-optical switching in GaAlAs integrated interferometer in 1.55 μm spectral region (1992)

The first observation is reported of ultrafast all-optical switching in an integrated asymmetric Mach-Zehnder inter-ferometer, using the nonresonant nonlinearity in Ga0.82Al0.18As below half the bandgap. A relative switching fraction of more than 80% has been achieved using 330 fs pulses at around 1.55 μm from a coupled-cavity mode-locked colour centre laser.
Diversity and Linkage of Genes in the Self-Incompatibility Gene Family in <i>Arabidopsis lyrata</i> (2003)

We report studies of seven members of the S-domain gene family in Arabidopsis lyrata, a member of the Brassicaceae that has a sporophytic self-incompatibility (SI) system. Orthologs for five loci are identifiable in the self-compatible relative A. thaliana. Like the Brassica stigmatic incompatibility protein locus (SRK), some of these genes have kinase domains. We show that several of these genes are unlinked to the putative A. lyrata SRK, Aly13. These genes have much lower nonsynonymous and synonymous polymorphism than Aly13 in the S-domains within natural populations, and differentiation between populations is higher, consistent with balancing selection at the Aly13 locus. One gene (Aly8) is linked to Aly13 and has high diversity. No departures from neutrality were detected for any of the loci. Comparing different loci within A. lyrata, sites corresponding to hypervariable regions in the Brassica S-loci (SLG and SRK) and in comparable regions of Aly13 have greater replacement site divergence than the rest of the S-domain. This suggests that the high polymorphism in these regions of incompatibility loci is due to balancing selection acting on sites within or near these regions, combined with low selective constraints.
DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes (2012)

Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for example, discordance rates for autoimmune diseases are 20%-80%. MZ discordance indicates a role for epigenetic or environmental factors in disease. We used MZ twins discordant for psoriasis to search for genome-wide differences in DNA methylation and gene expression in CD4(+) and CD8(+) cells using Illumina's HumanMethylation27 and HT-12 expression assays, respectively. Analysis of these data revealed no differentially methylated or expressed genes between co-twins when analyzed separately, although we observed a substantial amount of small differences. However, combined analysis of DNA methylation and gene expression identified genes where differences in DNA methylation between unaffected and affected twins were correlated with differences in gene expression. Several of the top-ranked genes according to significance of the correlation in CD4(+) cells are known to be associated with psoriasis. Further, gene ontology (GO) analysis revealed enrichment of biological processes associated with the immune response and clustering of genes in a biological pathway comprising cytokines and chemokines. These data suggest that DNA methylation is involved in an epigenetic dysregulation of biological pathways involved in the pathogenesis of psoriasis. This is the first study based on data from MZ twins discordant for psoriasis to detect epigenetic alterations that potentially contribute to development of the disease.
CLC‐3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis (2002)

These results indicated that the neurodegeneration observed in the Clcn3-/- mice was caused by an abnormality in the machinery which degrades the cellular protein and was associated with the phenotype of neuronal ceroid lipofuscinosis (NCL). The elevated endosomal pH could be an important factor in the pathogenesis of NCL.
Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection? (2003)

Since it was first claimed in 1995 that human chorionic gonadotropin (hCG) inhibits HIV-associated Kaposi's sarcoma (KS), focus has been lost on establishing a credible hypothesis to explain a novel action ascribed to hCG, which is, after all, a pregnancy hormone. After 7 years, no real progress has been made, and there remains no consensus as to which component of hCG preparations is responsible for inducing apoptosis of HIV-associated KS. It would certainly seem apparent that many basic experiments on hCG species have been overlooked in the studies that have been published. Furthermore, the much wider literature concerning the association of hCG with promoting oncogenesis has been ignored. This review puts into context the numerous studies on hCG, HIV-associated KS, and oncogenesis.
The LIGA technique and its potential for microsystems-a survey (1995)

The LIGA technique, which is being developed at the Research Center Karlsruhe, offers the possibility to manufacture microstructures with arbitrary lateral geometry, lateral dimensions down to below 1 /spl mu/m and aspect ratios up to 500 from a variety of materials (metals, plastics, and ceramics). The basic steps of X-ray lithography, electroplating, and plastic molding, are briefly described. Examples of applications of the LIGA technique are: optical components (high performance microspectrometer), mechanical components (acceleration sensor with integrated temperature compensation), and fluidic components (micropumps) which are presented and discussed. Microcomponents will be of limited interest in the future if it will not be possible to integrate them into microsystems. Microsystems must be more powerful than the sum total of their components. This is discussed in the final chapter of this article.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MAGNETIC ORIENTATION OF BI-2212 POWDER (2010)

The Accelerator Lab at Texas A&M is developing a method of texturing Bi‐2212 powder for an oriented powder multifilament round wire. Results of preliminary experiments relating to the orientation of Bi‐2212 powders by magnetic fields are presented.
An information flow security model for home area network of smart grid (2013)

Compared to the conventional home area network (HAN), the HAN in a smart grid environment features a higher level of innovative technologies and larger amounts of data, which demands a comprehensive approach to securing its data transmission and communications. In this paper, we analyze the information flow in the HAN and present a security model to secure the information in its transmission. An implementation method for applying the model in the HAN is proposed through embedding a component in every HAN device. Its function is to assign the security labels to the data packages and enforce the information flow policy. Results from the simulation show that it is effective to manage the information flow securely in the HAN.
The Pharmacological Potential of Mushrooms (2005)

This review describes pharmacologically active compounds from mushrooms. Compounds and complex substances with antimicrobial, antiviral, antitumor, antiallergic, immunomodulating, anti-inflammatory, antiatherogenic, hypoglycemic, hepatoprotective and central activities are covered, focusing on the review of recent literature. The production of mushrooms or mushroom compounds is discussed briefly.
TRAPS - classifiers of temporal patterns (1998)

The work proposes a radically di erent set of features for ASR where TempoRAl Patterns of spectral energies are used in place of the conventional spectral patterns. The approach has several inherent advantages, among them robustness to stationary or slowly varying disturbances.
Can germ cell neoplasia in situ be diagnosed by measuring serum levels of microRNA371a-3p? (2017)

Measuring miR-371a-3p serum levels can replace control biopsies after treatment of GCNis. In addition, the test can guide clinical decision making regarding the need of testicular biopsy in cases suspicious of GCNis.
Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations (2015)

The bioartificial kidney (BAK) aims at improving dialysis by developing 'living membranes' for cells-aided removal of uremic metabolites. Here, unique human conditionally immortalized proximal tubule epithelial cell (ciPTEC) monolayers were cultured on biofunctionalized MicroPES (polyethersulfone) hollow fiber membranes (HFM) and functionally tested using microfluidics. Tight monolayer formation was demonstrated by abundant zonula occludens-1 (ZO-1) protein expression along the tight junctions of matured ciPTEC on HFM. A clear barrier function of the monolayer was confirmed by limited diffusion of FITC-inulin. The activity of the organic cation transporter 2 (OCT2) in ciPTEC was evaluated in real-time using a perfusion system by confocal microscopy using 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP(+)) as a fluorescent substrate. Initial ASP(+) uptake was inhibited by a cationic uremic metabolites mixture and by the histamine H2-receptor antagonist, cimetidine. In conclusion, a 'living membrane' of renal epithelial cells on MicroPES HFM with demonstrated active organic cation transport was successfully established as a first step in BAK engineering.
Characterization of the potentiation effect of activin on human erythroid colony formation in vitro (1989)

Activin, also named FSH-releasing protein, was previously shown to induce hemoglobin accumulation in K562 cells and potentiate the proliferation and differentiation of CFU-E in human bone marrow cultures. Present studies indicate that the potentiation effect of activin is lineage specific. In addition to CFU-E, activin caused an increase in the colony formation of BFU-E from either bone marrow or peripheral blood. It had little effect on the colony formation of CFU-GM and the mixed colonies from CFU-GEMM. In serum-depleted culture, the effect of activin was shown to be dose-dependent with doses effective at picomolar concentrations. The potentiation effect of activin was exerted indirectly through mediation of both monocytes and T lymphocytes. Activin was also found to increase specifically the proportion of DNA-synthesizing erythroid progenitors from both bone marrow and peripheral blood. It had little effect on DNA synthesis in CFU-GM and in mitogen-stimulated lymphocytes. Addition of the monocytes or T lymphocytes to their respective depleted subpopulations of mononuclear cells reconstituted the enhancing effect of activin on the colony formation and DNA synthesis of erythroid progenitors. These results strongly suggest a specific role of activin in potentiating the proliferation and differentiation of erythroid progenitors in vitro.
Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues (1998)

The siglecs, formerly called sialoadhesins, are a family of I-type lectins binding to sialic acids on the cell surface. Five members of this family have been identified: sialoadhesin, myelin-associated glycoprotein (MAG), Schwann cell myelin protein (SMP), CD22 and CD33. We have investigated the relevance of substituents at position C-9 and in the N-acetyl group of N-acetylneuraminic acid, using a series of synthetic sialic-acid analogues either on resialylated human erythrocytes or as free alpha-glycosides in hapten inhibition. All five siglecs require the hydroxy group at C-9 for binding, suggesting hydrogen bonding of this substituent with the binding site. Remarkable differences were found among the proteins in their specificity for modifications of the N-acetyl group. Whereas sialoadhesin, MAG and SMP do not tolerate a hydroxy group as in N-glycolylneuraminic acid, they bind to halogenated acetyl residues. In the case of MAG, N-fluoroacetylneuraminic acid is bound about 17-fold better than N-acetylneuraminic acid. In contrast, human and murine CD22 both show good affinity for N-glycolylneuraminic acid, but only human CD22 bound the halogenated compounds. In conclusion, our data indicate that interactions of the hydroxy group at position 9 and the N-acyl substituent contribute significantly to the binding strength.
Design and optimization of MEMS piezoelectric energy harvesters for improved efficiency (2017)

This paper proposes an automated design and optimization methodology for performance improvement of the MEMS unimorph piezoelectric harvesters based on Genetic Algorithm (GA), which can be conducted with minimum human efforts. In this regard, an analytic equation, which can predict harvested voltage in terms of geometric dimensions, is utilized as an objective function of GA. By using micro-fabrication process, we fabricated the optimized MEMS harvesters. The experimental results demonstrate that the prototyped energy harvester has larger generated voltage magnitude by a factor of 31% in comparison with un-optimized ones, along with device area reduction from 3.1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> to 1.55 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Furthermore, a new T-shaped unimorph MEMS harvester with higher conversion efficiency from mechanical vibration to electricity by offering both bending stress and torsion stress, is proposed and fabricated. Our measurement shows that the T-shaped harvester can generate higher voltage by a factor of 96% with reference to the optimized conventional unimorph piezoelectric harvester, while its occupied area is further reduced by 35% to 1.01 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .