gebhart/patrepeval huggingface dataset:
Supporting location-based conditions in access control policies (2006)

Location-based Access Control (LBAC) techniques allow taking users' physical location into account when determining their access privileges. In this paper, we present an approach to LBAC aimed at integrating location-based conditions along with a generic access control model, so that a requestor can be granted or denied access by checking her location as well as her credentials. Our LBAC model includes a novel way of taking into account the limitations of the technology used to ascertain the location of the requester. Namely, we describe how location verification can be encapsulated as a service, representing location technologies underlying it in terms of two semantically uniform service level agreement (SLA) parameters called confidence and timeout. Based on these parameters, we present the formal definition of a number of location-based predicates, their management, evaluation, and enforcement. The challenges that such an extension to traditional access control policies inevitably carries are discussed also with reference to detailed examples of LBAC policies.
Towards a software-radio enabled broadcast media navigator (2004)

New consumer services are transforming the Hertzian broadcast media into a rich source of multimedia content. A broadcast media navigator combining software radio elements with audio indexing techniques and digital audio recording is proposed. Results from a PC-based demonstrator implementing a simple speech/music discriminator are presented.
ChemInform Abstract: Phenylcarbamates of (‐)‐Eseroline, (‐)‐N1‐Noreseroline and (‐)‐ Physovenol: Selective Inhibitors of Acetyl and/or Butyrylcholinesterase. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Activation of the cAMP-specific Phosphodiesterase PDE4D3 by Phosphorylation (1999)

Splicing variants of type 4 phosphodiesterases (PDE4) are regulated by phosphorylation. In these proteins, a conserved region is located between the amino-terminal domain, which is the target for phosphorylation, and the catalytic domain. Previous studies have indicated that nested deletions encompassing this region cause an increase in catalytic activity, suggesting this domain exerts an inhibitory constraint on catalysis. Here, we have further investigated the presence and function of this domain. A time-dependent increase in hydrolytic activity was observed when PDE4D3 from FRTL-5 cells was incubated with the endoproteinase Lys-C. The activation was abolished by protease inhibitors and was absent when a phosphorylated enzyme was used. Western blot analysis with PDE4D-specific antibodies indicated the Lys-C treatment separates the catalytic domain of PDE4D3 from the inhibitory domain. Incubation with antibodies recognizing an epitope within this domain caused a 3- to 4-fold increase in activity of native or recombinant PDE4D3. Again, PDE activation by these antibodies had properties similar to, and not additive with, the activation by protein kinase A phosphorylation. An interaction between the inhibitory domain and both regulatory and catalytic domains of PDE4D3 was detected by the yeast two-hybrid system. Mutations of Ser54 to Ala in the regulatory domain decreased or abolished this interaction, whereas mutations of Ser54 to the negatively charged Asp strengthened it. These data strongly support the hypothesis that an inhibitory domain is present in PDE4D and that phosphorylation of the regulatory domain causes activation of the enzyme by modulating the interaction between inhibitory and catalytic domains.
Factors influencing the ratio of free to total prostate-specific antigen in serum (1997)

The ratio of free prostate-specific antigen (f-PSA) to total PSA (t-PSA) in serum, calculated as percent free PSA (f-PSA%), is lower in patients with prostate carcinoma (PCa) than in patients with benign prostate hyperplasia (BPH). This parameter facilitates discrimination between the 2 groups of patients, but there is an overlapping of data. A better understanding of factors influencing this ratio is of practical importance. Therefore, f-PSA% was measured in controls and patients suffering from BPH, PCa and chronic prostatic inflammation with t-PSA concentrations up to 20 microg/l using the IMMULITE assays. The relationships of f-PSA% to clinical situation, age, prostate volume, kind of treatment, and stage and grade of tumor were calculated. Compared with controls or BPH patients, mean f-PSA% values were reduced in PCa patients and in patients with chronic prostatic inflammation. The prostate volume was the most important factor to influence f-PSA%. The difference of f-PSA% between PCa and BPH patients with prostate volumes smaller than 40 cm3 was lost if the prostate volumes exceeded 40 cm3. No relationship of f-PSA% to pTNM stage or grade of tumor was observed. In contrast to t-PSA concentrations, the f-PSA% values were not age-dependent and were not influenced by any kind of treatment in BPH and PCa patients either, which simplifies the use of f-PSA% compared with t-PSA. Thus, for using f-PSA% in clinical practice and for interpreting the data correctly, the advantages shown have to be considered along with the potential limitations of f-PSA%.
CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations (2017)

CRISPR-Cas9 has become a facile genome editing technology, yet the structural and mechanistic features underlying its function are unclear. Here, we perform extensive molecular simulations in an enhanced sampling regime, using a Gaussian-accelerated molecular dynamics (GaMD) methodology, which probes displacements over hundreds of microseconds to milliseconds, to reveal the conformational dynamics of the endonuclease Cas9 during its activation toward catalysis. We disclose the conformational transition of Cas9 from its apo form to the RNA-bound form, suggesting a mechanism for RNA recruitment in which the domain relocations cause the formation of a positively charged cavity for nucleic acid binding. GaMD also reveals the conformation of a catalytically competent Cas9, which is prone for catalysis and whose experimental characterization is still limited. We show that, upon DNA binding, the conformational dynamics of the HNH domain triggers the formation of the active state, explaining how the HNH domain exerts a conformational control domain over DNA cleavage [Sternberg SH et al. (2015) <i>Nature</i>, <i>527</i>, 110-113]. These results provide atomic-level information on the molecular mechanism of CRISPR-Cas9 that will inspire future experimental investigations aimed at fully clarifying the biophysics of this unique genome editing machinery and at developing new tools for nucleic acid manipulation based on CRISPR-Cas9.
Video stabilization using robust feature trajectories (2009)

This paper proposes a new approach for video stabilization. Most existing video stabilization methods adopt a framework of three steps, motion estimation, motion compensation and image composition. Camera motion is often estimated based on pairwise registration between frames. Thus, these methods often assume static scenes or distant backgrounds. Furthermore, for scenes with moving objects, robust methods are required for finding the dominant motion. Such assumptions and judgements could lead to errors in motion parameters. Errors are compounded by motion compensation which smoothes motion parameters. This paper proposes a method to directly stabilize a video without explicitly estimating camera motion, thus assuming neither motion models nor dominant motion. The method first extracts robust feature trajectories from the input video. Optimization is then performed to find a set of transformations to smooth out these trajectories and stabilize the video. In addition, the optimization also considers quality of the stabilized video and selects a video with not only smooth camera motion but also less unfilled area after stabilization. Experiments show that our method can deal with complicated videos containing near, large and multiple moving objects.
Coaching Considerations for the Tire Flip (2010)

THE PURPOSE OF THIS COLUMN IS TO PROVIDE A BASIC RECOMMENDATION TO INTEGRATING AND APPLYING THE TIRE FLIP EXERCISE TO THE STRENGTH AND CONDITIONING PROGRAM. IT WILL LOOK AT FACTORS SUCH AS SELECTING A TIRE, PERFORMING THE EXERCISE CORRECTLY, COMMON TECHNICAL FLAWS, AND HOW TO SPOT THE EXERCISE.
3G Cellular Phone Signal Optical Transmission over Gigabit E-PON System (2005)

We have demonstrated third generation (3G) cellular phone signal optical transmission over a gigabit Ethernet passive optical network (GE-PON) system using 20km single mode fiber (SMF) with 30dB optical loss budget. Cellular phone signals were wavelength-division-multiplexed with GE-PON signals. We have confirmed the possibility of accommodating CDMA2000 1xEV-DO signals residing in 800MHz band on existing optical access networks.
Intra Prediction Offset Compensation for Improving Video Coding Efficiency (2009)

본 논문은 H.264/AVC 화면내 부호화에서 부호화 효율 향상을 위해 율-왜곡 최적화를 이용한 화면내 예측 오프셋 보상 방법을 제안한다. H.264/AVC의 화면내 예측 부호화는 주변 블록의 복원 화소들을 현재 부호화하려는 블록의 예측 블록으로 활용함으로써 공간적 상관성을 제거하고 부호화 효율을 향상시킨다. 제안 방법은 화면내 부호화의 예측 오차를 감소시키기 위해, 율-왜곡 비용 관점에서의 최적 값을 갖는 화면내 예측 오프셋을 기존 화면내 예측 블록에 더하여 예측 블록의 정확도를 높인다. 따라서 예측 오차 신호의 양자화된 변환 계수를 감소시키며 원본 블록과 복원된 블록 간의 왜곡을 감소시켜 화면내 블록의 부호화 성능을 향상시킬 수 있다. 추가적으로, 휘도 성분의 부호화 성능 향상을 위해 화면내 예측 오프셋 보상이 사용되는 화면내 블록의 색차 성분에 JM 11.0에서 화면간 부호화에서 사용되는 계수 임계 처리 방법을 적용한다. 본 논문의 실험에서는 제안하는 방법이 JM 11.0과 비교 실험했을 때 High Profile 환경에서 평균 2.45%의 비트율 감소와 최대 4.41%의 비트율을 감소시킬 수 있음을 보인다. In this paper, an intra prediction offset compensation method is proposed to improve intra prediction in H.264/AVC. In H.264/AVC, intra prediction based on various directions improves the coding efficiency by removing spatial correlation between neighboring blocks. In details, neighboring pixels in reconstructed block can be used as intra reference block for the current block to be coded when intra prediction method is used. In order to reduce further the prediction error of the intra reference block, the proposed method introduces an intra prediction offset which is determined in the sense of the rate-distortion optimization and is added to the conventional intra prediction block. Besides the intra prediction offset compensation, the coefficient thresholding method which is used for inter coding in JM 11.0, is used for chroma component in intra block, which leads the improvement of the luma coding efficiency of the proposed method. In experiments, we show that the proposed method achieves average 2.45% in High Profile condition and maximum 4.41% of bitrate reduction relative to JM 11.0.
Quantum Key Distribution (QKD) Protocols: A Survey (2018)

The security strength of key distribution of most conventional cryptography is relied on mathematical complexity and the irrational time needed to break the algorithm. But it will be ineffective if the secret key distribution procedure is weak. In 1994 Peter Shor proposed an algorithm that can factorize great integer number efficiently by using principle of quantum computer, this algorithm poses a threat to some of the conventional cryptography. Recently, Quantum Key Distribution (QKD) is drawing much attention of researcher as a solution of that problem of key distribution. Theoretically, QKD have been proven can be provide unconditionally secure communication based on quantum mechanics laws. In this article we survey the QKD protocols. Also, we present a little experiment of some QKD protocols that we discussed on this paper.
Lamb and SH wave transducer arrays for the inspection of large areas of thick plates (2000)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation P. Wilcox, M. Lowe, P. Cawley; Lamb and SH wave transducer arrays for the inspection of large areas of thick plates. AIP Conf. Proc. 23 May 2000; 509 (1): 1049–1056. https://doi.org/10.1063/1.1306159 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
The European Medicines Agency Review of Pomalidomide in Combination With Low-Dose Dexamethasone for the Treatment of Adult Patients With Multiple Myeloma: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use (2015)

On August 5, 2013, a marketing authorization valid throughout the European Union (EU) was issued for pomalidomide in combination with dexamethasone for the treatment of adult patients with relapsed and refractory multiple myeloma (MM) who have received at least two prior treatment regimens, including both lenalidomide and bortezomib, and have demonstrated disease progression on the last therapy. Pomalidomide is an immunomodulating agent. The recommended starting dose of pomalidomide is 4 mg once daily taken on days 1-21 of repeated 28-day cycles. The main evidence of efficacy for pomalidomide in MM was based on a phase III multicenter, randomized, open-label study (CC-4047-MM-003) in which pomalidomide plus low-dose dexamethasone therapy (POM+LoDEX) was compared with high-dose dexamethasone alone (HiDEX) in previously treated adult patients with relapsed and refractory multiple myeloma who had received at least two prior treatment regimens, including both lenalidomide and bortezomib, and had demonstrated disease progression on the last therapy. For the intent-to-treat population, median progression-free survival based on International Myeloma Working Group criteria was 15.7 weeks (95% confidence interval [CI]: 13.0-20.1) in the POM+LoDEX group versus 8.0 weeks (95% CI: 7.0-9.0) in the HiDEX group (log-rank p value <.001). Overall survival (secondary endpoint) was also different in the two treatment groups (hazard ratio 0.53 [95% CI: 0.37-0.74]). The most commonly reported adverse reactions to pomalidomide in clinical studies were anemia (45.7%), neutropenia (45.3%) and thrombocytopenia (27%), fatigue (28.3%), pyrexia (21%), peripheral edema (13%), and infections including pneumonia (10.7%). Peripheral neuropathy adverse reactions were reported in 12.3% of patients, and venous embolic or thrombotic (VTE) adverse reactions were reported in 3.3% of patients. Pomalidomide is expected to be teratogenic. This paper summarizes the scientific review of the application leading to approval in the EU. The detailed scientific assessment report and product information, including the summary of product characteristics, are available on the EMA website (http://www.ema.europa.eu).
Decreased Seizure Activity in a Human Neonate Treated With Bumetanide, an Inhibitor of the Na<sup>+</sup>-K<sup>+</sup>-2Cl<sup>-</sup> Cotransporter NKCC1 (2009)

Neonatal seizures have devastating consequences for brain development and are inadequately treated by available antiepileptics. In neonates, gamma-aminobutyric acid (GABA) is an excitatory neurotransmitter due to elevated levels of intraneuronal chloride achieved by robust activity of the Na(+)-K(+)-2Cl( -) cotransporter (NKCC1). This depolarizing action of GABA likely contributes to the lowered seizure threshold, increased seizure propensity, and poor efficacy of GABAergic anticonvulsants among infants. The diuretic bumetanide inhibits NKCC1 and silences seizure activity in rodent models of neonatal seizures, but its effect on seizures in human neonates is unknown. Continuous electroencephalography (EEG) monitoring was used to quantify the number, duration, and frequency of seizures 2 hours before and after the administration of bumetanide in a neonate with intractable multifocal seizures. Significant reductions in mean seizure duration and frequency were noted following treatment, with no associated clinical side effects or metabolic imbalances. These results suggest bumetanide may exert antiepileptic effects in human neonates.
Nextpresso: Next Generation Sequencing Expression Analysis Pipeline (2017)

Background: Many bioinformatics pipelines are available nowadays to analyze transcriptomics data produced by high-throughput RNA sequencing. They implement different workflows that address several analysis tasks, supported by the use of third party programs. Nevertheless, a proper workflow definition for RNA-seq data analysis is still lacking. Objective: To proper define what a comprehensive RNA-seq data analysis workflow should be. Compare all available pipelines and, if such a solution is not available, implement a new pipeline. Method: We have developed a new pipeline integrating state-of-the art programs for different parts of the RNA-seq analysis. We also have used RUbioSeq libraries to achieve a scalable solution. Results: We have defined a comprehensive RNA-seq data analysis workflow, comprising the most common needs demanded by biologists and implemented it in a new pipeline, nextpresso. We also validate it in two case studies presented here. Conclusion: Nexpresso is a new, freely available, pipeline covering the most common needs of RNA-seq data analysis. It is easy to configure, generates user friendly results and scales well for larger studies comprising a high number of samples. Keywords: RNA-seq, next generation sequencing, transcriptomics, workflow, pipeline, spike-in controls, concurrent processing.
Fucosylated but Not Sialylated Milk Oligosaccharides Diminish Colon Motor Contractions (2013)

Human milk oligosaccharides (HMO) are being studied by different groups exploring a broad range of potential beneficial effects to the breastfed infant. Many of these effects have been attributed to a growth promotion effect on certain gut organisms such as bifidobacteria. Additionally, evidence indicates that HMO are able to directly promote positive changes in gut epithelium and immune responses under certain conditions. This study utilizes a standardized ex vivo murine colon preparation to examine the effects of sialylated, fucosylated and other HMO on gut motor contractions. Only the fucosylated molecules, 2'FL and 3'FL, decreased contractility in a concentration dependent fashion. On the basis of IC50 determinations 3'FL was greater than 2 times more effective than 2'FL. The HMO 3'SL and 6'SL, lacto-N-neotetraose (LNnT), and galactooligosaccharides (GOS) elicited no effects. Lactose was used as a negative control. Fucosylation seems to underlie this functional regulation of gut contractility by oligosaccharides, and L-fucose, while it was also capable of reducing contractility, was substantially less effective than 3'FL and 2'FL. These results suggest that specific HMO are unlikely to be having these effects via bifidogenesis, but though direct action on neuronally dependent gut migrating motor complexes is likely and fucosylation is important in providing this function, we cannot conclusively shown that this is not indirectly mediated. Furthermore they support the possibility that fucosylated sugars and fucose might be useful as therapeutic or preventative adjuncts in disorders of gut motility, and possibly also have beneficial central nervous system effects.
Towards embedded control for resonant scanning MEMS micromirror (2009)

This paper describes the design and realization of an electrostatic actuated MEMS mirror operating at a resonance frequency of 23.5 KHz with a PLL feedback loop. The design is based upon a thorough understanding of the (non-linear) dynamical behavior of the mirror. Using an external position sensitive device (PSD) the proper working of the PLL is demonstrated. Next we study the possibility to replace the PSD sensor with an embedded capacitive phase-angle sensor. We show measurements of capacitance changes with large parasitic influences while actuating the mirror in a feed forward mode. This demonstrates the feasibility of a fully embedded control for a resonant scanning MEMS mirror. Keywords: MEMS micromirror; laser display; raster scanning, capacitive tilt-angle sensor; PLL
A Review of Warfarin Dosing and Monitoring (2001)

"A Review of Warfarin Dosing and Monitoring." Baylor University Medical Center Proceedings, 14(3), pp. 305–306
Speech understanding and aging (1988)

The increasing age of the population forecasts a corresponding increase in the number of people suffering from hearing loss and who therefore have difficulty with speech communication. This article, prepared by the Working Group on Speech Understanding and Aging for the Committee on Hearing, Bioacoustics, and Biomechanics, discusses a number of the factors that act on the elderly listener’s ability to understand speech, including physiological aging, changes in cognitive ability, noisy signals, and sensory aids. Both sensory and perceptual processes are considered.
Joint Power Control, Base Station Assignment, and Channel Assignment in Cognitive Femtocell Networks (2010)

Cognitive radio and femtocells are recent technology breakthroughs that aim to achieve throughput improvement by means of spectrum management and interference mitigation, respectively. However, these technologies are limited by the former's susceptibility to interference and the latter's dependence on bandwidth availability. In this paper, we overcome these limitations by integrating cognitive radio and femtocell technology and exploring its feasibility and throughput improvement. To realize this, we propose an integrated architecture and formulate a multiobjective optimization problem with mixed integer variables for the joint power control, base station assignment, and channel assignment scheme. In order to find a pareto optimal solution, a weighted sum approach was used. Based on numerical results, the optimization framework is found to be both stable and converging. Simulation studies further show that the proposed architecture and optimization framework improve the aggregate throughput as the client population rises, hence confirming the successful and beneficial integration of these technologies.
ChemInform Abstract: 1‐Hydroxy‐7‐azabenzotriazole: An Efficient Peptide Coupling Additive. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.