gebhart/patrepeval huggingface dataset:
The Damping Effects of Viscoelastic Materials: Part 2—Transverse Vibrations of Plates With Viscoelastic Coatings (1971)

An energy method is employed to analyze a nonhomogeneous, damped plate composed of an elastic (metal) layer and an unconstrained viscoelastic layer. This analysis is limited to the case of thin plates subject to no constraints and vibrating freely in the fundamental mode. The theory developed enables one to predict the damped natural frequency and the rate of decay (in terms of logarithmic decrement) of the transverse vibrations of a composite plate of given dimensions and composed of two particular materials. Experimental measurements bear out the fact that theoretical predictions are indeed accurate. Plates with two symmetric viscoelastic coatings are also considered and their damping effects are compared to those of coatings applied to one side only.
Insulin cell mass is altered in<i>Csf1</i><i>op</i><i>/Csf1</i><i>op</i>macrophage-deficient mice (2004)

Macrophages play an important role in organ development, tissue homeostasis, and remodeling. Thus, we monitored the presence of F4/80-positive macrophages in the pancreas of wild-type mice, and some developmental features of this complex tissue were compared throughout life in wild-type and macrophage-deficient Csf1op/Csf1op (op/op) mice. The combined use of immunohistochemistry, morphometry, and cell quantification allows us to evaluate insulin and glucagon cell mass, total and insulin cell proliferation, and apoptosis in fetuses (E18.5), weanings (postnatal day 21), nonpregnant adults, and adults in late pregnancy (18.5 days). F4/80-positive macrophages were found in pancreases recovered from Csf1op/Csf1+ (op/+) mice but were extremely scarce or absent in pancreas recovered from op/op ones at all studied time-points. The macrophage-deficient op/op phenotype was clearly associated with a major insulin mass deficit in fetuses and adults, abnormal postnatal islet morphogenesis, and impaired pancreatic cell proliferation at weaning and late pregnancy. We also obtained indirect evidence of increased neogenesis in this model at time-points when pancreatic remodeling does occur. The demonstration of the colony-stimulating factor 1-dependent macrophage involvement in life-time pancreas development/remodeling allows us to pinpoint the tissue-modeling and remodeling functions of this leukocyte lineage.
Block Constrained Trellis Coded Vector Quantization of LSF Parameters for Wideband Speech Codecs (2008)

ABSTRACTIn this paper, block constrained trellis coded vector quantization (BC-TCVQ) is presented for quantizing the line spectrum frequency parameters of the wideband speech codec. Both a predictive structure and a safety-net concept are combined into BC-TCVQ to develop the predictive BC-TCVQ. The performance of this quantization is compared with that of the linear predictive coding vector quantizer used in the AMR-WB codec, demonstrating reductions in spectral distortion. KeywordsSpeech coding, quantization, trellis coded vector quantization, LSF parameters.
Hereditary multiple exostosis and chondrosarcoma: linkage to chromosome II and loss of heterozygosity for EXT-linked markers on chromosomes II and 8. (1995)

Hereditary multiple exostosis (EXT) is an autosomal dominant disorder characterized by bony exostoses at the ends of the long bones. Linkage studies have recently suggested that there are three chromosomal locations for EXT genes, 8q24.1 (EXT1), the pericentric region of 11 (EXT2), and 19p (EXT3). As part of a larger study to determine the frequencies of the three EXT types in the United States, we have ascertained a large multigenerational family with EXT and one family member with a chondrosarcoma. This family demonstrated linkage of the disease to chromosome 11 markers. The constitutional and tumor DNAs from the affected family member were compared using short-tandem-repeat markers from chromosomes 8, 11, and 19. Loss of heterozygosity (LOH) in the tumor was observed for chromosome 8 and 11 markers, but chromosome 19 markers were intact. An apparent deletion of the marker D11S903 was observed in constitutional DNA from all affected individuals and in the tumor sample. These results indicate that the EXT2 gene maps to the region containing marker D11S903, which is flanked by markers D11S1355 and D11S1361. Additional constitutional and chondrosarcoma DNA pairs from six unrelated individuals, two of whom had EXT, were similarly analyzed. One tumor from an individual with EXT demonstrated LOH for chromosome 8 markers, and a person with a sporadic chondrosarcoma was found to have tumor-specific LOH and a homozygous deletion of chromosome 11 markers. These findings suggest that EXT genes may be tumor-suppressor genes and that the initiation of tumor development may follow a multistep model.
The process of empathic response (1981)

(1981). The process of empathic response. Psychoanalytic Inquiry: Vol. 1, On empathy, pp. 393-416.
Realizing the promise of breast cancer vaccines (2012)

Abstract: Breast cancer vaccines are being developed to stimulate adaptive antitumor immune responses in patients. These vaccines have the potential to treat breast cancer with minimal side effects and toxicity. However, many obstacles still need to be overcome to fully realize the vaccines' clinical benefit. A review of the literature was conducted to assess the use of vaccines in targeting transformed cells. Four vaccines currently under study were discussed, each summarizing the different vaccine platforms used to introduce target antigen to the patient's immune system. The advantages and disadvantages of each method were discussed, although no one method was found to be superior. Additional issues addressed included overcoming tumor-induced immunosuppression, immune evasion of transformed cells, the use of vaccines in combination therapy, and the challenges of using these vaccines in various clinical settings. Vaccines may be most effective in patients with minimal residual disease, as opposed to using them in the metastatic setting. Also, specific clinical trial design considerations for the use of vaccines in cancer patients, such as time-to-failure end points, were discussed. Understanding these various elements will be important to the translation of breast cancer vaccine therapy into routine clinical practice. Keywords: breast cancer, vaccine, immunotherapy, immune tolerance, peptide vaccine, dendritic cell vaccine
Resistless, area-selective ultrashallow <i>P</i>+/<i>N</i> junction fabrication using projection gas immersion laser doping (1996)

The selective fabrication of ultrashallow p+/n junctions in silicon using projection gas immersion laser doping is reported. The method offers substantial improvement and simplification in junction formation to integrated circuit manufacturers, since several processing steps required for conventional doping techniques like ion implantation are eliminated. Spatially selective incorporation of boron into silicon without the use of any masking layer on the wafer surface is achieved. A pulsed excimer laser beam is patterned using a chromeless reticle and the pattern is transferred through a projection system onto a wafer that is kept in a BF3 dopant gas ambient. The depth of the fabricated junctions is 60 nm with a surface concentration of 5×1019 cm−3. The vertical and lateral distribution of boron in silicon after patterned laser processing is investigated using secondary ion mass spectroscopy (SIMS) and time-of-flight SIMS (ToF-SIMS). Vertical and lateral dopant profiles are steep and clearly resolved.
Characterization of Molecular Adsorbates on a Flat Surface Using Infrared and Raman Spectroscopy (2014)

振動分光法の基本である赤外及びラマン分光法により，薄膜の分子配向を解析する考え方について述べる．分子凝縮系である薄膜のスペクトルを解析するには電磁気学が基本理論で，赤外分光法については表面選択律という極めて平易なルールにまとめることができ，簡単に官能基単位での分子配向を議論することが可能である．ラマン分光法による定量的分子配向の実際についても，赤外分光法と比較しながら概略を述べる．
Functional Transplantation of the Rat Pituitary Gland (1998)

These data suggest survival of neonatal pituitary transplants in the third ventricle of adult hypophysectomized rats with concomitant restoration of anterior pituitary hormone function.
Protective Effects of .GAMMA.-Aminobutyric Acid in Rats with Streptozotocin-Induced Diabetes (2005)

The effects of gamma-aminobutyric acid (GABA) in rats with experimental diabetes mellitus were examined. Diabetes mellitus was induced in adult male Wistar rats by streptozotocin (STZ) injection. Oral administration of GABA (100 or 200 mg/kg body weight/d) for 10 d to the diabetic rats resulted in a significant decrease in their serum glucose level. GABA also reduced the level of glycosylated protein in serum, indicating an improvement of hyperglycemic conditions. Rats with STZ-induced diabetes showed arrested body weight gain and an increase in both liver and kidney weight, whereas oral administration of GABA attenuated the organ hypertrophy induced by hyperglycemia. In addition, the degree of serum thiobarbituric acid (TBA)-reactive substance level was significantly lower in the rats treated with 100 mg GABA, and the degree of TBA-reactive substance in the liver and kidney was reduced by GABA in a dose-dependent manner. These results suggest that GABA treatment protects against the development of diabetic complications resulting from impaired glucose metabolism and enhanced oxidative stress.
Towards an application framework for automated planning and scheduling (1997)

A number of successful applications of automated planning and scheduling applications to spacecraft operations have recently been reported in the literature. However, these applications have been one-of-a-kind applications that required a substantial amount of development effort. In this paper, we describe ASPEN (Automated Planning/Scheduling Environment), a modular, reconfigurable application framework which is capable of supporting a wide variety of planning and scheduling applications. We describe the architecture of ASPEN, as well as a number of current spacecraft control/operations applications in progress.
Use of Systemic Blood Urea Nitrogen Levels Obtained 30 Minutes before the End of Hemodialysis to Portray Equilibrated, Postdialysis Blood Urea Nitrogen Values (2000)

Blood urea nitrogen (BUN) levels obtained at 30 minutes before the end of dialysis were found to be closely similar to equilibrated, postdialysis BUN values obtained 30 minutes after the end of dialysis. Because of this similarity, the former BUN values can be used to derive equilibrated urea reduction ratio, or equilibrated Kt/V instead.
IMPRESSO À TINTA: Notas sobre experiência, viewpoints e a dança contemporânea (2014)

O artigo aborda a experiência e os princípios dos Viewpoints atravessados pelo olhar de uma artista criadora que, ao tecer as impressões sobre o seu fazer, entrelaça conceitos e ações. Na primeira parte é relatado um processo de criação performático que ocorreu em locais públicos na cidade de Uberlândia- MG e a partir dele é feita uma relação entre a experiência e o ato de criar. Em um segundo momento propõe-se um paralelo entre as qualidades apontadas por Anne Bogart ao trabalhar com os Viewpoints e a criação em dança contemporânea. Objetiva-se, portanto, através do presente artigo, promover um campo de reflexões oriundo das impressões provocadas por experiências significativas no campo da criação.
The use of oxinol and other alcohol blending components in gasoline (1982)

OXINOL blending component, a blend of methanol and gasoline-grade tertiary-butyl alcohol, has been successfully market tested by both Atlantic Richfield Company and Sun Company. The results of these market tests, covering the blending, distribution, and customer satisfaction with OXINOL gasoline blends, are discussed. In addition, this paper reviews the octane value of OXINOL and other alcohol blending components, the blending characteristics of these components and compare their economic value relative to other octane enhancers, including refinery processing options.
Cleavage of Supercoiled DNA by Deoxyribonuclease I in Solution and at the Electrode Surface (1999)

Cleavage of supercoiled DNA by deoxyribonuclease I (DNase I) in solution and at the surface of the mercury electrode was studied by means of AC voltammetry. This technique produces peak 3 which is produced only by DNAs containing free ends (such as linear double-stranded and single-stranded DNAs and open circular DNAs) but not by covalently closed circular (ccc) DNAs. Formation of a single interruption of the sugar-phosphate backbone in the ccc supercoiled (sc) DNA results in formation of peak 3. Peak 1 is produced by both ccc DNA molecules as well as by DNAs containing free ends; changes in height of this peak occur due to DNA cleavage. We show that the kinetics of the cleavage of DNA in solution and at the electrode surface substantially differ suggesting restricted accessibility of the surface-confined DNA for the interaction with the enzyme. Cleavage of the immobilized DNA is remarkably influenced by the potential of the electrode surface. At positively charged surface the enzymatic reaction is inhibited in its initial stage while moderately negative charges stimulate the cleavage of the immobilized DNA by DNase I.
Bioactive food components and cancer risk reduction (2007)

Research over the last three decades has provided convincing evidence to support the premise that diets rich in fruits and vegetables may be protective against the risk of different types of cancers. Initial evidence for protective effect of fruits and vegetables against cancer risk came from population-based case-control studies, which prompted intense research aimed at (a) identification of bioactive component(s) responsible for the anticancer effects of fruits and vegetables, (b) elucidation of the mechanisms by which bioactive food components may prevent cancer, and (c) determination of their efficacy for prevention of cancer in animal models. The bioactive components responsible for cancer chemopreventive effects of various edible plants have now been identified. For instance, anticancer effect of Allium vegetables including garlic is attributed to organosulfur compounds (e.g., diallyl trisulfide). Interestingly, unlike cancer chemotherapy drugs, many bioactive food components selectively target cancer cells. Molecular basis for selectivity of anticancer bioactive food components towards cancer cells remains elusive, but these agents appear promiscuous and target multiple signal transduction pathways to inhibit cancer cell growth in vitro and in vivo. Despite convincing observational and experimental evidence, however, limited effort has been directed towards clinical investigations to determine efficacy of bioactive food components for prevention of human cancers. This article reviews current knowledge on cancer chemopreventive effects of a few highly promising dietary constituents, including garlic-derived organosulfides, berry compounds, and cruciferous vegetable-derived isothiocyanates, and serves to illustrate complexity of the signal transduction mechanisms in cancer chemoprevention by these promising bioactive food components.
Tortuosity Determination of Battery Electrodes and Separators by Impedance Spectroscopy (2016)

Lithium ion battery performance at high charge/discharge rates is largely determined by the ionic resistivity of an electrode and separator which are filled with electrolyte. Key to understand and to model ohmic losses in porous battery components is porosity as well as tortuosity. In the first part, we use impedance spectroscopy measurements in a new experimental setup to obtain the tortuosities and MacMullin numbers of some commonly used separators, demonstrating experimental errors of <8%. In the second part, we present impedance measurements of electrodes in symmetric cells using a blocking electrode configuration, which is obtained by using a non-intercalating electrolyte. The effective ionic resistivity of the electrode can be fit with a transmission-line model, allowing us to quantify the porosity dependent MacMullin numbers and tortuosities of electrodes with different active materials and different conductive carbon content. Best agreement between the transmission-line model and the impedance data is found when constant-phase elements rather than simple capacitors are used.
The Multiligand α<sub>2</sub>‐Macroglobulin Receptor/Low Density Lipoprotein Receptor‐Related Protein (α<sub>2</sub>MR/LRP) (1994)

The fusion of separate lines of research has greatly helped in elucidating the function of the giant members of the low density lipoprotein (LDL) receptor (LDLR) supergene family. The cDNA encoding a large protein structurally closely related to LDLR, and hence named LDLR-related protein (LRP), was cloned by Herz et al. in 1988.'Evidence was provided demonstrating that LRP can function as a receptor for chylomicron remnants@-migrating very low density lipoproteins (P-VLDL) rich in apolipoprotein E (apoE)?' The a2-macroglobulin (a2M) receptor (a2MR) was purified from rat livep and human p l a~e n t ab~y. ~af finity chromatography using immobilized a2M in the receptor-active conformation (a2M*). The first fusion occurred with the demonstration of identity between a2MR and LRP.'.' The receptor was thought to play the role of a double agent: as symbolized by its double name. The next fusion arose from the observation that affinity-purified a2MR/LRP contains a 40-kDa5.8 or 39-kDa6.' protein, designated a2MRAP, in addition to the a2MFULRP a- and P-chains. cDNA cloning" disclosed the 323-residue protein as both the human homologue of mouse heparin binding protein 44 (see reference 11) and, interestingly, a sequence thought to be the pathogenic domain12 of rat epithelial glycoprotein 330 (gp330), the Heymann nephritis antigen. gp330 is another giant member of the LDLR family according to the sequence of the partially cloned cDNA.''
A hardware-based multi-objective thread mapper for tiled manycore architectures (2015)

Thread mapping is typically performed as an integral part of cooperative or pre-emptive operating system (OS) scheduling in order to share the processor core(s) among competing applications. Schedulers usually follow a single-objective performance optimization, such as maximizing core utilization or satisfying deadlines by the prioritization of threads. Meeting multiple orthogonal objectives, like performance vs. power or thermal resilience, in the era of manycore processors is a challenge because of the associated scalability and thread management overhead. We tackle these challenges by employing a two stage thread management strategy. In the first stage (not covered in this short paper), threads are assigned to regions or compute tiles. For the second stage we introduce in this paper the TCU (Thread Control Unit), a configurable, low latency, low overhead hardware thread mapper that takes various runtime sensor parameters into account. It can map threads within a small and bounded number of clock cycles in round robin, single or multi-objective manner. TCU is designed to consider not just load balancing or performance criteria but also physical constraints like power budgets, temperature limits and reliability aspects. TCU macro achieves 150K thread mappings per second on a tiled MPSoC FPGA prototype while operating at moderate 50 Mz. Evaluations of different mapping policies show that multi-objective thread mapping provides about 10 to 40% less mapping latency for periodic and bursty traffic compared to single-objective or round robin schemes. FPGA and ASIC syntheses reveal a 9% hardware overhead for the TCU on a four core compute tile.
Formation of silver particles and periodic precipitate layers in silicate glass induced by thermally assisted hydrogen permeation (2000)

Nanoscale silver particles embedded in sodium silicate glass were produced by Na/Ag ion exchange and subsequent thermal treatment in a hydrogen atmosphere. Their structure and spatial distribution were studied by conventional and high-resolution electron microscopy (HREM). Two different mechanisms of particle formation could be identified: (i) reduction of ionic silver by hydrogen and formation of mostly defective particles (twinned) within a near-surface region; and (ii) formation of single-crystalline particles in the interior of the glass resulting from reduction by means of polyvalent iron ions. Electron microscopy investigation revealed the completion of periodic layers of silver particles in near-surface regions with high silver concentration induced by thermally assisted hydrogen permeation. The self-organized periodic layer formation may be explained in terms of Ostwald's supersaturation theory, assuming interdiffusion of two mobile species. Analysis of lattice plane spacings from HREM images of silver particles revealed the typical size-dependent lattice contraction. The extent of this, however, was found to be different for particles formed by hydrogen permeation and those formed by interaction with polyvalent iron ions. These differences reflect different influences of the surrounding glass matrix, probably originating from the conditions of particle formation (thermal history).
Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2 <sup>high</sup> Breast Cancer (2016)

We propose that the ETC is a suitable therapeutic target in Her2<sup>high</sup> disease. Antioxid. Redox Signal. 26, 84-103.
Photochromism of chromene crystals; a new property of old chromenes (2000)

Of the four chromene compounds; 3,3-diphenyl-5,10a-dihydro-3H-benzo[f]chromene (CHR1), 6-methoxy-2,2-diphenyl-2H-benzo[h]chromene (CHR2), 2,2-diphenyl-2H-benzo[h]chromene (CHR3) and 6,7-dimethoxy-2,2- diphenyl-2H-chromene (CHR4), CHR2–4 exhibited crystalline state photochromism.
Nickel is a component of hydrogenase in Rhizobium japonicum (1984)

The derepression of H2-oxidizing activity in free-living Rhizobium japonicum does not require the addition of exogenous metal to the derepression media. However, the addition of EDTA (6 microM) inhibited derepression of H2 uptake activity by 80%. The addition of 5 microM nickel to the derepression medium overcame the EDTA inhibition. The addition of 5 microM Cu or Zn also relieved EDTA inhibition, but to a much lesser extent; 5 microM Fe, Co, Mg, or Mn did not. The kinetics of induction and magnitude of H2 uptake activity in the presence of EDTA plus Ni were similar to those of normally derepressed cells. Nickel also relieved EDTA inhibition of methylene blue-dependent Hup activity, suggesting that nickel is involved directly with the H2-activating hydrogenase enzyme. Adding nickel or EDTA to either whole cells or crude extracts after derepression did not affect the hydrogenase activity. Cells were grown in 63Ni and the hydrogenase was subsequently purified by gel electrophoresis. 63Ni comigrated with the H2-dependent methylene blue reducing activity on native polyacrylamide gels and native isoelectric focusing gels. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the nickel-containing hydrogenase band revealed a single polypeptide with a molecular weight of ca. 67,000. We conclude that the hydrogenase enzyme in R. japonicum is a nickel-containing metalloprotein.
The regulation of expression of human beta-globin genes. (1987)

We have analyzed the regulation of expression of the human beta-globin gene by DNA mediated gene transfer in MEL cells and microinjection in fertilized mouse eggs. The results show that the beta-globin gene contains two regulatory elements: one element in the promoter, that is required for full transcriptional activity and, secondly, a tissue and developmental specific enhancer 3' to the gene.