gebhart/patrepeval huggingface dataset:
IBM eServer z900 I/O subsystem (2002)

The IBM eServer z900 is the first in a generation of future eServers that continues its leadership via a new I/O subsystem with enhancements in capability, performance, configuration management, and qualities of service. Significant features of the I/O subsystem are included to support the 64-bit z/Architecture™ and configuration-management enhancements [e.g., assignable channel path identifiers (CHPIDs) and dynamic channel path management (DCM)]. A 1GB/s self-timed interface (STI), I/O infrastructure, and I/O card cage are described which support the high-bandwidth I/O (e.g., FICON™, Ethernet). These improvements yield enhanced configuration flexibility and connectivity, as well as reliability, availability, and serviceability (RAS), while providing for future bandwidth growth. The various types of I/O ports supported by the IBM eServer z900 platform are also discussed. A common I/O platform is discussed which has been used to provide a uniform, high-bandwidth attachment of industry-standard peripheral computer interface (PCI) cards, while maintaining the leadership functionality and RAS of the eServer zSeries™. A high-density (16-port) ESCON® I/O card has been designed by exploiting IBM advanced CMOS and state-of-the-art fiber optic technologies. Finally, a high-performance, high-density intersystem channel (ISC-3) coupling link I/O card has been developed for the IBM eServer z900 by leveraging advanced technology and packaging techniques.
Cross-linked poly(vinyl alcohol) as permanent hydrophilic column coating for capillary electrophoresis (2001)

A fast method for the generation of permanent hydrophilic capillary coatings for capillary electrophoresis (CE) is presented. Such interior coating is effected by treating the surface to be coated with a solution of glutaraldehyde as cross-linking agent followed by a solution of poly(vinyl alcohol) (PVA), which results in an immobilization of the polymer on the capillary surface. Applied for capillary zone electrophoresis (CZE) such capillaries coated with cross-linked PVA exhibit excellent separation performance of adsorptive analytes like basic proteins due to the reduction of analyte-wall interactions. The long-term stability of cross-linked PVA coatings could be proved in very long series of CZE separations. More than 1000 repetitive CE separations of basic proteins were performed with stable absolute migration times relative standard deviation (RSD > 1.2%) and without loss of separation efficiency. Cross-linked PVA coatings exhibit a suppressed electroosmotic flow and excellent stability over a wide pH range.
Temporal multi-hierarchy smoothing for estimating rates of rare events (2011)

We consider the problem of estimating rates of rare events obtained through interactions among several categorical variables that are heavy-tailed and hierarchical. In our previous work, we proposed a scalable log-linear model called LMMH (Log-Linear Models for Multiple Hierarchies) that combats data sparsity at granular levels through small sample size corrections that borrow strength from rate estimates at coarser resolutions. This paper extends our previous work in two directions. First, we model excess heterogeneity by fitting local LMMH models to relatively homogeneous subsets of the data. To ensure scalable computation, these subsets are induced through a decision tree, we call this Treed-LMMH. Second, the Treed-LMMH method is coupled with temporal smoothing procedure based on a fast Kalman filter style algorithm. We show that simultaneously performing hierarchical and temporal smoothing leads to significant improvement in predictive accuracy. Our methods are illustrated on a large scale computational advertising dataset consisting of billions of observations and hundreds of millions of attribute combinations(cells).
Learning Curve of Small Incision Lenticule Extraction: Challenges and Complications (2017)

The learning curve of SMILE is surgically challenging. Lenticule dissection and extraction is the most difficult step and leads to a multitude of complications. Most complications that result in delayed visual recovery are observed in the initial 50 cases.
Acute Aquatoxicity of Chemicals to Carp and Changes of Toxicity Values Dependent on Treatment (1984)

This study was performed to evaluate the aquatoxicity of 5 chemicals (butachlor, isoprothiolane, probenazole, carbofuran, and cartap) to carp (Cyprinus carpio), discuss the impact on the values of the chemicals with the exposure time. In butachlor, we also compared the acute toxicity values between two exposure system, the continuous flow system and static state system, and measured the dissolved oxygen concentrations in the two systems. The acute toxicity values (96 hr-LC50 values) of the 5 chemicals were 0.25 ppm in butachlor, 10.0 ppm in isoprothiolane, 6.2 ppm in probenazole, 1.40 ppm in carbofuran, and 0.64 ppm in cartap, respectively. We also found that the values were downed with increase of the exposure time.
Content Feature Schema for Internet Fax (V2) (2000)

This document defines a content media feature schema for Internet fax.It is a profile of the media feature registration mechanisms [1,2,3] for use in performing capability identification between extended Internet fax systems [5].It replaces and updates the feature schema defined in RFC 2531.
Phase II, Open-Label Study of Brivanib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma (2011)

Brivanib as first-line therapy demonstrates promising antitumor activity and a manageable safety profile in patients with advanced, unresectable HCC.
Microphthalmia‐Associated Transcription Factor in the Wnt Signaling Pathway (2003)

Microphthalmia-associated transcription factor (MITF) contains a basic helix-loop-helix and leucine-zipper (bHLH-LZ) structure and consists of many isoforms with different N-termini. Melanocyte-specific MITF isoform (MITF-M) is of particular interest, because a heterozygous mutation in the MITF gene is associated with Waardenburg syndrome type 2 (WS2) that is characterized by deafness and hypopigmentation because of lack of melanocytes in the inner ear and skin. Expression of MITF-M is under the regulation of the melanocyte-specific promoter (M promoter) of the MITF gene, and transcription from the M promoter is induced by Wnt signals through a nuclear mediator, lymphoid-enhancing factor 1 (LEF-1). In addition, functional cooperation of MITF-M with LEF-1 could lead to transcriptional activation of the M promoter and the dopachrome tautomerase (DCT) gene, an early melanoblast marker. The bHLH-LZ region of MITF-M is responsible for the physical interaction with LEF-1, and beta-catenin is required for the collaboration between LEF-1 and MITF-M. Importantly, MITF-M could function as a non-DNA-binding co-factor for LEF-1. These results suggest that MITF-M may function as a self-regulator of its own expression to maintain a threshold level of MITF-M at a certain sensitive stage of melanocyte development, which could account for the dominant inheritance of WS2. MITF-M therefore plays dual roles in the Wnt signaling pathway; MITF-M represents a downstream target and a nuclear mediator of Wnt signals in melanocytes.
Mouse Genome Informatics (MGI): reflecting on 25 years (2015)

From its inception in 1989, the mission of the Mouse Genome Informatics (MGI) resource remains to integrate genetic, genomic, and biological data about the laboratory mouse to facilitate the study of human health and disease. This mission is ever more feasible as the revolution in genetics knowledge, the ability to sequence genomes, and the ability to specifically manipulate mammalian genomes are now at our fingertips. Through major paradigm shifts in biological research and computer technologies, MGI has adapted and evolved to become an integral part of the larger global bioinformatics infrastructure and honed its ability to provide authoritative reference datasets used and incorporated by many other established bioinformatics resources. Here, we review some of the major changes in research approaches over that last quarter century, how these changes are reflected in the MGI resource you use today, and what may be around the next corner.
Transcriptomic Analyses of Xylan Degradation by Prevotella bryantii and Insights into Energy Acquisition by Xylanolytic Bacteroidetes (2010)

Enzymatic depolymerization of lignocellulose by microbes in the bovine rumen and the human colon is critical to gut health and function within the host. Prevotella bryantii B(1)4 is a rumen bacterium that efficiently degrades soluble xylan. To identify the genes harnessed by this bacterium to degrade xylan, the transcriptomes of P. bryantii cultured on either wheat arabinoxylan or a mixture of its monosaccharide components were compared by DNA microarray and RNA sequencing approaches. The most highly induced genes formed a cluster that contained putative outer membrane proteins analogous to the starch utilization system identified in the prominent human gut symbiont Bacteroides thetaiotaomicron. The arrangement of genes in the cluster was highly conserved in other xylanolytic Bacteroidetes, suggesting that the mechanism employed by xylan utilizers in this phylum is conserved. A number of genes encoding proteins with unassigned function were also induced on wheat arabinoxylan. Among these proteins, a hypothetical protein with low similarity to glycoside hydrolases was shown to possess endoxylanase activity and subsequently assigned to glycoside hydrolase family 5. The enzyme was designated PbXyn5A. Two of the most similar proteins to PbXyn5A were hypothetical proteins from human colonic Bacteroides spp., and when expressed each protein exhibited endoxylanase activity. By using site-directed mutagenesis, we identified two amino acid residues that likely serve as the catalytic acid/base and nucleophile as in other GH5 proteins. This study therefore provides insights into capture of energy by xylanolytic Bacteroidetes and the application of their enzymes as a resource in the biofuel industry.
Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response (2010)

TFR is a unique immune-mediated phenomenon noted with lenalidomide treatment only in patients with CLL that correlates with clinical response. It can be effectively managed with anti-inflammatory agents.
État du développement technologique en matière d'enlèvement des métaux des effluents industriels (2005)

Cette étude trace un profil des diverses technologies utilisées et en développement pour la séparation et/ou la récupération des métaux dans les effluents industriels. Les principes de fonctionnement de ces technologies sont abordés, ainsi que leurs avantages et limites d'utilisation. Les procédés d'enlèvement et de récupération des métaux comprennent les techniques de précipitation (formation d'hydroxydes, de carbonates, de sulfures, etc.) et coprécipitation (sels de fer et d'aluminium, etc.), d'adsorption (sable, cellulose, charbon activé, pyrite, ciment, lignite, mousse de tourbe, sciure de bois, etc.) et de biosorption (bactéries, levures, moisissures, algues marines et d'eaux douces), d'électrodéposition et d'électrocoagulation, de cémentation, de séparation par membranes (osmose inverse et électrodialyse), d'extraction par solvant (acides carboxyliques, amines aliphatiques ou aromatiques, acides aminés, composés phénoliques, phosphates alkyl, etc.), et d'échange d'ions (résines naturelles et synthétiques). La précipitation ou la coprécipitation représentent les procédés les plus largement utilisés et étudiés pour l'enlèvement des métaux des effluents industriels, suivis des techniques d'adsorption. Les procédés plus sophistiqués tels que l'électrodéposition, l'extraction par solvant, la séparation par membranes et l'échange d'ions, bien que largement utilisés dans les procédés métallurgiques, sont relativement peu employés et examinés pour le traitement des effluents industriels. La biosorption a fait l'objet de plusieurs travaux de recherche au cours des dernières années et représente une option intéressante pour le traitement de divers types d'effluents contenant de faibles concentrations en métaux. Finalement, le recyclage et la gestion optimale des effluents constitue une avenue de plus en plus suivie par les industries soucieuses de satisfaire aux nouvelles réglementations et législations.
Calculations of the surface temperature rise and desorption temperature in laser-induced thermal desorption (1986)

The laser-induced thermal desorption (LITD) process is discussed with reference to measurements of the translational energies (temperatures) of desorbed molecules. We present simple expressions which predict both the surface temperature rise for a laser-heated surface and the desorption temperature in LITD. We show that these approximations are excellent descriptions of the laser heating and LITD processes. These expressions are convenient alternatives to numerical solutions of the heat conduction and desorption rate equations using the actual shape of a laser pulse and specific combinations of kinetic parameters.
The fundamental topoi of relational communication (1984)

La communication dite «relationnelle» est traditionnellement reputee se deployer selon deux ou trois dimensions. On presente ici, a partir d'une analyse multidisciplinaire (anthropologie, psychotherapie, expression des emotions, analyse de contenu...) un schema en douze dimensions: dominance/soumission, intimite, affection/hostilite, implication personnelle, inclusion/exclusion, confiance, profondeur/superficialite, vivacite des emotions, sang-froid, ressemblance, formalisme, socialite
Separation of Metabolites and Macromolecules for Short-TE <sup>1</sup>H-MRSI Using Learned Component-Specific Representations (2021)

Short-echo-time (TE) proton magnetic resonance spectroscopic imaging (MRSI) allows for simultaneously mapping a number of molecules in the brain, and has been recognized as an important tool for studying in vivo biochemistry in various neuroscience and disease applications. However, separation of the metabolite and macromolecule (MM) signals present in the short-TE data with significant spectral overlaps remains a major technical challenge. This work introduces a new approach to solve this problem by integrating imaging physics and representation learning. Specifically, a mixed unsupervised and supervised learning-based strategy was developed to learn the metabolite and MM-specific low-dimensional representations using deep autoencoders. A constrained reconstruction formulation is proposed to integrate the MRSI spatiospectral encoding model and the learned representations as effective constraints for signal separation. An efficient algorithm was developed to solve the resulting optimization problem with provable convergence. Simulation and experimental results have been obtained to demonstrate the component-specific representation power of the learned models and the capability of the proposed method in separating metabolite and MM signals for practical short-TE [Formula: see text]-MRSI data.
Selected Papers from the Third European Conference on Artificial Evolution (1995)

From the Publisher:
This book constitutes the thoroughly refereed post-proceedings of the 5th International Conference on Artificial Evolution, EA 2001, held in Le Creusot, France, in October 2001. The 28 revised full papers presented together with an invited paper were carefully selected and improved during two rounds of reviewing and revision. The papers are organized in topical sections on theoretical issues, algorithmic issues, applications, implementation issues, genetic programming, constraint handling, and co-evolution and agent systems.
Cooperative relaying scheme with space time code for multihop communications among single antenna terminals (2005)

In mobile multihop communications, the diversity technique is important since the channel between mobile terminals may suffer from the effects of fading and the routes between terminals are normally created through several hops. Space-time coding using multiple transmit antennas is an effective countermeasure for fading. For terminals which have only one antenna, due to the size/cost limitations, user cooperation has been introduced as a diversity technique. In this paper, a space-time coded cooperative relaying scheme for a multihop communications scenario, in cases where the number of hops is more than two, is proposed in order to combat the effects of fading among single antenna terminals, without bandwidth expansion. The scheme utilizes a space-time code for cooperative relaying and is developed in both frequency-flat and frequency-selective fading channels. By computer simulations, it is shown that the proposed scheme provides diversity gain and more improvement of frame error rate as the number of hops increases. Furthermore, the effects of an error correcting code and co-channel interference are shown.
Was Contamination of Southern California Groundwater By Chlorinated Solvents Foreseen? (2001)

The historical record does not support the argument that the cause of widespread groundwater contamination by chlorinated solvents in southern California was an inability to anticipate or detect the problem. The propensity of industrial wastes, including chlorinated solvents, to contaminate groundwater was understood by the 1940s in southern California. This understanding was not limited to small group of specialists, but extended to regulators, industry, and the interested public. Industrial waste disposal was deregulated in 1949 as result of lobbying by industry, despite warning from the director of the State Health Department that such action would create a backlog of water pollution over the State that will constitute plague comparable to the air pollution in Los Angeles. Regulators warned specifically about the danger that groundwater pollution in the San Fernando and San Gabriel valleys would result from improper disposals of industrial chemicals, and solvents were identified as major cont...
Kinetic Isotope Effects in the Study of Organometallic Reaction Mechanisms (2011)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTKinetic Isotope Effects in the Study of Organometallic Reaction MechanismsMar Gómez-Gallego* and Miguel A. Sierra*View Author Information Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense, 28040 Madrid, SpainE-mail: (M.G.-G.) [email protected], (M.A.S.) [email protected]Cite this: Chem. Rev. 2011, 111, 8, 4857–4963Publication Date (Web):May 5, 2011Publication History Received16 December 2010Published online5 May 2011Published inissue 10 August 2011https://pubs.acs.org/doi/10.1021/cr100436khttps://doi.org/10.1021/cr100436kreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views22131Altmetric-Citations604LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Hydrocarbons,Isotope effects,Reaction mechanisms,Transition states Get e-Alerts
Beta-Catenin/HuR Post-Transcriptional Machinery Governs Cancer Stem Cell Features in Response to Hypoxia (2013)

Hypoxia has been long-time acknowledged as major cancer-promoting microenvironment. In such an energy-restrictive condition, post-transcriptional mechanisms gain importance over the energy-expensive gene transcription machinery. Here we show that the onset of hypoxia-induced cancer stem cell features requires the beta-catenin-dependent post-transcriptional up-regulation of CA9 and SNAI2 gene expression. In response to hypoxia, beta-catenin moves from the plasma membrane to the cytoplasm where it binds and stabilizes SNAI2 and CA9 mRNAs, in cooperation with the mRNA stabilizing protein HuR. We also provide evidence that the post-transcriptional activity of cytoplasmic beta-catenin operates under normoxia in basal-like/triple-negative breast cancer cells, where the beta-catenin knockdown suppresses the stem cell phenotype in vitro and tumor growth in vivo. In such cells, we unravel the generalized involvement of the beta-catenin-driven machinery in the stabilization of EGF-induced mRNAs, including the cancer stem cell regulator IL6. Our study highlights the crucial role of post-transcriptional mechanisms in the maintenance/acquisition of cancer stem cell features and suggests that the hindrance of cytoplasmic beta-catenin function may represent an unprecedented strategy for targeting breast cancer stem/basal-like cells.
Highly Luminescent CdSe/ZnS Nanocrystals Synthesized Using a Single‐Molecular ZnS Source in a Microfluidic Reactor (2005)

Abstract An air‐stable, low‐toxicity, single‐molecular source for ZnS is demonstrated to be an appropriate reagent to synthesize highly luminescent ZnS‐capped CdSe with a narrow size distribution. A photoluminescence quantum yield of above 50 % and a photoluminescence peak full width at half maximum of around 32 nm could be obtained after synthesis using a microreactor. The surface of the ZnS‐capped CdSe nanocrystals can be hydrophilic, while retaining the high quantum yield. Microscopic observation shows that accurate time control, which could be achieved by using a microreactor, is important to avoid the formation of many isolated ZnS particles and the deterioration of the luminescence.
Syndecan-1 antigen, a promising new target for triple-negative breast cancer immuno-PET and radioimmunotherapy. A preclinical study on MDA-MB-468 xenograft tumors (2011)

These results demonstrate that RIT with 131I-B-B4 could be considered for the treatment of metastatic triple-negative breast cancer that cannot benefit from hormone therapy or anti-Her2/neu immunotherapy. Immuno-PET for visualizing CD138-expressing tumors with 124I-B-B4 reinforces the interest of this mAb for diagnosis and quantitative imaging.
Type-Safe Linkage for C++. (1988)

We introduce a new concept for the manipulation of fluid flow around three-dimensional bodies. Inspired by transformation optics, the concept is based on a mathematical idea of coordinate transformations and physically implemented with anisotropic porous media permeable to the flow of fluids. In two situations-for an impermeable object placed either in a free-flowing fluid or in a fluid-filled porous medium-we show that the object can be coated with an inhomogeneous, anisotropic permeable medium, such as to preserve the flow that would have existed in the absence of the object. The proposed fluid flow cloak eliminates downstream wake and compensates viscous drag, hinting at the possibility of novel propulsion techniques.