gebhart/patrepeval huggingface dataset:
Story Forest (2020)

Extracting events accurately from vast news corpora and organize events logically is critical for news apps and search engines, which aim to organize news information collected from the Internet and present it to users in the most sensible forms. Intuitively speaking, an event is a group of news documents that report the same news incident possibly in different ways. In this article, we describe our experience of implementing a news content organization system at Tencent to discover events from vast streams of breaking news and to evolve news story structures in an online fashion. Our real-world system faces unique challenges in contrast to previous studies on topic detection and tracking (TDT) and event timeline or graph generation, in that we (1) need to accurately and quickly extract distinguishable events from massive streams of long text documents, and (2) must develop the structures of event stories in an online manner, in order to guarantee a consistent user viewing experience. In solving these challenges, we propose Story Forest , a set of online schemes that automatically clusters streaming documents into events, while connecting related events in growing trees to tell evolving stories. A core novelty of our Story Forest system is EventX , a semi-supervised scheme to extract events from massive Internet news corpora. EventX relies on a two-layered, graph-based clustering procedure to group documents into fine-grained events. We conducted extensive evaluations based on (1) 60 GB of real-world Chinese news data, (2) a large Chinese Internet news dataset that contains 11,748 news articles with truth event labels, and (3) the 20 News Groups English dataset, through detailed pilot user experience studies. The results demonstrate the superior capabilities of Story Forest to accurately identify events and organize news text into a logical structure that is appealing to human readers.
Advances in opportunistic radio technologies for TVWS (2011)

Cognitive radio has been an active research area in wireless communications over the past 10 years. TV Digital Switch Over resulted in new regulatory regimes, which offer the first large-scale opportunity for cognitive radio and networks. This article considers the most recent regulatory rules for TV White Space opportunistic usage, and proposes technologies to operate in these bands. It addresses techniques to assess channel vacancy by the cognitive radio, focusing on the two incumbent systems of the TV bands, namely TV stations and wireless microphones. Spectrum-sensing performance is discussed under TV White Space regulation parameters. Then, modulation schemes for the opportunistic radio are discussed, showing the limitations of classical multi-carrier techniques and the advantages of filter bank modulations. In particular, the low adjacent band leakage of filter bank is addressed, and its benefit for spectrum pooling is stressed as a means to offer broadband access through channel aggregation.
Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model (2015)

A mouse model that recapitulates the human Ewing's sarcoma-specific chromosomal translocation was generated utilizing the Cre/loxP-mediated recombination technique. A cross between Ewsr1-loxP and Fli1-loxP mice and expression of ubiquitous Cre recombinase induced a specific translocation between Ewsr1 and Fli1 loci in systemic organs of both adult mice and embryos. As a result Ewsr1-Fli1 fusion transcripts were expressed, suggesting a functional Ews-Fli1 protein might be synthesized in vivo. However, by two years of age, none of the Ewsr1-loxP/Fli1-loxP/CAG-Cre (EFCC) mice developed any malignancies, including Ewing-like small round cell sarcoma. Unexpectedly, all the EFCC mice suffered from dilated cardiomyopathy and died of chronic cardiac failure. Genetic recombination between Ewsr1 and Fli1 was confirmed in the myocardial tissue and apoptotic cell death of cardiac myocytes was observed at significantly higher frequency in EFCC mice. Moreover, expression of Ews-Fli1 in the cultured cardiac myocytes induced apoptosis. Collectively, these results indicated that ectopic expression of the Ews-Fli1 oncogene stimulated apoptotic signals, and suggested an important relationship between oncogenic signals and cellular context in the cell-of-origin of Ewing's sarcoma.
Developmental Hazard of Environmentally Persistent Free Radicals and Protective Effect of TEMPOL in Zebrafish Model (2021)

Environmentally persistent free radicals (EPFRs) can be detected in ambient PM<sub>2.5</sub>, cigarette smoke, and soils and are formed through combustion and thermal processing of organic materials. The hazards of EPFRs are largely unknown. In this study, we assess the developmental toxicity of EPFRs and the ability of TEMPOL (4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl) to protect against such hazards using zebrafish embryos. Particles containing EPFRs were acquired by dosing dichlorobenzene (DCB) vapor on the Cab-o-sil/5% CuO particles at 230 °C in vacuo (referred to as DCB-230). The particles were suspended in ultrapure water to make 1 mg/mL of stock solution from which series dilution was undertaken to obtain 10, 20, 30, 40, 50, 60, 80, and 100 µg/mL final test solutions, which were then placed in individual wells with a 4 h postfertilization (hpf) zebrafish embryo. Plates were run in duplicate to obtain a sample size of 24 animals per concentration; 12 embryos were exposed per concentration per plate. Statistical analysis of the morphology endpoints was performed. We investigated overt toxicity responses to DCB-230 in a 22-endpoint battery that included developing zebrafish from 24-120 hpf. Exposure to concentrations greater than 60 µg/mL of DCB-230 induced high mortality in the developmental zebrafish model. Exposure to EPFRs induced developmental hazards that were closely related to the concentrations of free radicals and EPFRs. The potential protective effects of TEMPOL against EPFRs' toxicity in zebrafish were investigated. Exposure to EPFRs plus TEMPOL shifted the concentration to an induced 50% adverse effect (EC50), from 23.6 to 30.8 µg/mL, which verifies TEMPOL's protective effect against EPFRs in the early phase of zebrafish development.
Randomized Trial of Nutrient-Enriched Formula Versus Standard Formula for Postdischarge Preterm Infants (2001)

1) Improving postdischarge nutrition in the first 9 months may "reset" subsequent growth-at least until 18 months for body length. We intend to follow-up the children at older ages. The observed efficacy of PDF was not associated with adverse safety outcomes. 2) We cannot reject the hypothesis that postdischarge nutrition benefits motor development and this requires additional study. 3) Our data raise the possibility that breastfed postdischarge preterm infants may require nutritional supplementation, currently under investigation.
HDL and integrating system-level simulation technologies (2002)

System level design is a critical component of any electronics product development project. However, HDL based ASIC design has remained a distinctive and separate function within projects. With the advent of deep submicron technology, large systems and subsystems can now be placed on a single chip. This requires a closer interaction between system level design and ASIC development. The paper describes an effective methodology and technology support for integrating system level simulation techniques with HDL based simulation to provide a smooth transition between each level. We start by examining an integrated verification methodology and the use models for utilizing mixed dataflow and HDL models. We then discuss combining a model of interaction derived from the work done on the Ptolemy project with a standards based implementation approach using the Open Model Forum (OMF) standard. Finally, an example is used to highlight the effectiveness of this approach.
Prostate Cancer Risk Alleles are Associated with Prostate Cancer Volume and Prostate Size (2013)

Analysis of 38 single nucleotide polymorphisms associated with prostate cancer risk revealed a significant association between several on chromosome 8q24 and increased tumor volume but not prostate volume. This suggests that they are bona fide markers of prostate cancer susceptibility and possibly more aggressive disease. Other prostate cancer risk alleles are associated with prostate specific antigen and increased prostate or decreased tumor volume, suggesting detection bias due to their phenotypic influence.
Strategy for Safe Performance of Extrathoracic Magnetic Resonance Imaging at 1.5 Tesla in the Presence of Cardiac Pacemakers in Non–Pacemaker-Dependent Patients (2006)

Extrathoracic MRI of non-pacemaker-dependent patients can be performed with an acceptable risk-benefit ratio under controlled conditions and by taking both MR- and pacemaker-related precautions.
TISSUE CULTURE STUDIES ON HUMAN PITUITARY TUMOURS: LONG TERM RELEASE OF ANTERIOR PITUITARY HORMONES INTO THE CULTURE MEDIUM (1979)

A study was undertaken to determine the length of time that human pituitary tumours are capable of releasing anterior pituitary polypeptide hormones in vitro under basal conditions and to study the spectrum of hormone release by functioning and "non-functioning" pituitary neoplasms. Fragments from the pituitary tumours of 10 patients in the following categories: 1 Cushing's disease, 2 with amenorrhoea-galactorrhoea, 3 with acromegaly, and 4 with "non-functioning" pituitary tumours and from 2 normal human anterior pituitary glands were placed in primary culture immediately after surgery. The in vitro release of human growth hormone (hGH), prolactin (Prl), thyrotrophin (TSH), adrenocorticotrophin (ACTH), luteinizing hormone (LH), and follicle stimulating hormone (FSH) was measured by specific radioimmunoassays at the end of each week in culture. Hormone release was surveyed from 6 weeks to 6 months depending upon the survival of the culture. Hormone release patterns were compared with clinical and pathological data. In the initial week of the study, all 6 anterior pituitary polypeptides were detected in the media from the 2 control pituitaries and from 4 of the tumours (1 amenorrhoea-galactorrhoea and 3 acromegaly) in concentrations up to 100 ng/ml of medium while 5 of the 6 hormones were readily detectable in the media from 2 additional tumour samples (Cushing's disease and 1 "non-functioning" pituitary tumour). The media of the remaining 4 tumours contained at least 3 of the 6 hormones (1 amenorrhoea-galactorrhoea and 3 "non-functioning" pituitary tumours). After 6 months in culture, the 6 hormones were readily detectable in at least 1 of the 5 surviving cultures and hGH (up to 800 ng/ml) and LH were each detectable in the media from 2 cultures. Although most of the hormone concentrations in the media decreased with length of time in culture, there were 2 exceptions. First in the media from 5 of the 12 cultures from both controls and tumours, Prl concentrations increased after 50 to 80 days culture. This increase usually lasted for several weeks before Prl levels again began to decline. The second unusual finding occurred in a tumour from a patient with acromegaly in the media of which hGH levels rose from 60 ng/ml to 800 ng/ml between days 125 and 174. These findings of prolonged hormone release in vitro give promise of future usefulness of tissue culture methods for study of polypeptide hormone releasing mechanisms and long-term production of human anterior pituitary hormones for use in research and possible therapy.
π–π Interaction Energies as Determinants of the Photodimerization of Mono-, Di-, and Triazastilbenes (2014)

We describe the quantitative [2 + 2] photocycloaddition of crystalline trans-2,4-dichloro-6-styrylpyrimidine to produce the corresponding htt r-ctt cyclobutane dimer, and we present (1)H NMR analysis of the photolysis of this and six other mono-, di-, and triazastilbenes in solid and solution states. Density functional (M06-2X) and correlated ab initio (MP2) calculations were used to obtain interaction energies between two monomers of each azastilbene. These energies mirror the relative polarization of the stilbene moieties and can be quantitatively correlated with the rate of reaction and selective formation of the htt r-ctt dimers. In the solid state, poor correlation is observed between interaction energy and reactivity/selectivity. This lack of correlation is explained through X-ray analysis of the azastilbene monomers and is shown to be in accordance with the principles of Schmidt's topochemical postulate. Conversely, in solution there is a strong positive correlation (R(2) = 0.96) between interaction energies and formation of the htt r-ctt dimer. These results are the first to show this correlation and to demonstrate the utility of calculated interaction energies as a tool for the prediction of stereo- and regioselectivity in solution-state stilbene-type photocycloadditions.
The Surgical Learning Curve for Modified Lapidus Procedure for Hallux Valgus Deformity (2021)

Level IV: Retrospective.
Analysis of load balancing methods for improving of utilization efficiency of hardware resources of distributed systems (2013)

The present paper concerns scalability and elasticity characteristics of distributed systems. To achieve high efficiency of the system the use of dynamic load balancing methods is proposed. The analysis of efficiency of proposed methods and their impact on quality of service of distributed systems is performed.
Development of Multiplex Wiring Systems in Automobiles (1988)

<div class="htmlview paragraph">This paper describes the technical features of the automotive multiplex wiring system (VICS-1) using the new custom LSI.</div> <div class="htmlview paragraph">Technical highlights included in this paper are as follows: <ul class="list disc"> <li class="list-item"><div class="htmlview paragraph">Operation of the multiplex system</div></li> <li class="list-item"><div class="htmlview paragraph">Functions of the network interface LSI</div></li> <li class="list-item"><div class="htmlview paragraph">Low power stand-by mode operation</div></li> <li class="list-item"><div class="htmlview paragraph">Fail-safe operation</div></li> <li class="list-item"><div class="htmlview paragraph">Diagnostics features</div></li> </ul></div>
Visual Analysis of Controversy in User-Generated Encyclopedias (2008)

Wikipedia is a large and rapidly growing Web-based collaborative authoring environment, where anyone on the Internet can create, modify, and delete pages about encyclopedic topics. A remarkable property of some Wikipedia pages is that they are written by up to thousands of authors who may have contradicting opinions. In this paper, we show that a visual analysis of the ‘who revises whom’-network gives deep insight into controversies. We propose a set of analysis and visualization techniques that reveal the dominant authors of a page, the roles they play, and the alters they confront. Thereby we provide tools to understand how Wikipedia authors collaborate in the presence of controversy.
Genomic Islands of Uropathogenic <i>Escherichia coli</i> Contribute to Virulence (2009)

Uropathogenic Escherichia coli (UPEC) strain CFT073 contains 13 large genomic islands ranging in size from 32 kb to 123 kb. Eleven of these genomic islands were individually deleted from the genome, and nine isogenic mutants were tested for their ability to colonize the CBA/J mouse model of ascending urinary tract infection. Three genomic island mutants (Delta PAI-aspV, Delta PAI-metV, and Delta PAI-asnT) were significantly outcompeted by wild-type CFT073 in the bladders and/or kidneys following transurethral cochallenge (P <or= 0.0139). The PAI-metV mutant also showed significant attenuation in the ability to independently colonize the kidneys (P = 0.0011). Specific genes within these islands contributed to the observed phenotype, including a previously uncharacterized iron acquisition cluster, fbpABCD (c0294 to c0297 [c0294-97]), autotransporter, picU (c0350), and RTX family exoprotein, tosA (c0363) in the PAI-aspV island. The double deletion mutant with deletions in both copies of the fbp iron acquisition operon (Deltac0294-97 Delta c2518-15) was significantly outcompeted by wild-type CFT073 in cochallenge. Strains with mutations in a type VI secretion system within the PAI-metV island did not show attenuation. The attenuation of the PAI-metV island was localized to genes c3405-10, encoding a putative phosphotransferase transport system, which is common to UPEC and avian pathogenic E. coli strains but absent from E. coli K-12. We have shown that, in addition to encoding virulence genes, genomic islands contribute to the overall fitness of UPEC strain CFT073 in vivo.
Photorelaxation Processes in Covalently Linked Indocarbocyanine and Thiacarbocyanine Dyes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotorelaxation Processes in Covalently Linked Indocarbocyanine and Thiacarbocyanine DyesA. K. Chibisov, G. V. Zakharova, H. Goerner, Yu. A. Sogulyaev, I. L. Mushkalo, and A. I. TolmachevCite this: J. Phys. Chem. 1995, 99, 3, 886–893Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/j100003a009https://doi.org/10.1021/j100003a009research-articleACS PublicationsRequest reuse permissionsArticle Views539Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Structural properties of DNA oligomers containing (GACX)<sub><i>n</i></sub> and (GAXC)<sub><i>n</i></sub> tandem repeats (2011)

The antisense DNA sequence of mature mouse micro RNA, miR341, includes three repeats of the tetranucleotide (GACC). The -GAC- repeat is known to form a parallel duplex, in acidic environments. The thermal melting profile of miR341 DNA, at pH 4, 5, and 6 indicates the formation of a very stable structure, which loses its stability when pH is increased. Thus, the addition of a cytosine at the 3' end of the (GAC) motif preserves the molecule's potential to fold into an unusual structure at low pH. The effect of modifying the nucleotide composition of the GACC sequence on the secondary structures formed by oligomers containing seven tandem repeats of the altered motifs was examined here. UV melting profiles were determined, as a function of pH, for 28-mers of the two series (GAXC)(7) and (GACX)(7) (X= A/C/T/G)(.) The sequence (GACC)(7) was found to be extremely sensitive to pH variations, with a stable structure formed at pH 5 (T(m) ≥ 60°C). NMR spectroscopy established that the low pH structure is not B-DNA. (GACA)(7) and (GACT)(7) also formed stable structures at low pH but the addition of guanine at the 3'end, as seen in the (GACG) series resulted in the loss of this property. Introducing a break in the 5'-GAC-3' motif, explored in the (GAXC) series, also inhibits formation of stable structures under acidic conditions.
Widefield TSCSPC-systems with large-area-detectors: application in simultaneous multi-channel-FLIM (2010)

Novel proximity-type Time- and Space-Correlated Single Photon Counting (TSCSPC) crossed-delay-line (DL)- and multi-anode (MA)-systems of outstanding performance and homogeneity were developed, using large-area detector heads of 25 and 40 mm diameter. Instrument response functions IRF(space) = (60 ± 5) μm FWHM and IRF(time) = (28 ± 3) ps FWHM were achieved over the full 12 cm<sup>2</sup> area of the detector. Deadtime at throughput of 10<sup>5</sup> cps is 10% for "high-resolution" system and 5% in the "video"-system at 10<sup>6</sup> cps, at slightly reduced time- and space resolution. A fluorescence lifetime of (3.5 ± 1) ps can be recovered from multi-exponential dynamics of a single living cyanobacterium (Acaryochloris marina). The present large-area detectors are particularly useful in simultaneous multichannel applications, such as 2-colour anisotropy or 4-colour lifetime imaging, utilizing dual- or quad-view image splitters. The long-term stability, low- excitation-intensity (< 100 mW/cm<sup>2</sup>) widefield systems enable minimal-invasive observation, without significant bleaching or photodynamic reactions, thus allowing long-period observation of up to several hours in living cells.
Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes (2009)

Sonic hedgehog (SHH) plays an important role in postnatal tissue repair. The present study tested the hypothesis that impaired SHH pathway results in delayed wound healing by suppressing cutaneous nitric oxide (NO) function in type 1 diabetes. Adult male C57/B6 mice and streptozotocin (STZ)-induced type 1 diabetic mice were used. Although cutaneous SHH and Patched-1 (Ptc-1 encoded by PTCH, PTCH 1) proteins were increased significantly on day 4 after wounding compared with day 0 in normal mice, both were decreased significantly in STZ-induced diabetic mice. Topical application of SHH restored wound healing delay in STZ-induced diabetic mice, with a concomitant augmentation of both cutaneous constitutive nitric oxide synthase (NOS) activity and nitrite level. The effects of SHH on wound healing and cutaneous NO function were markedly inhibited by SHH receptor inhibitor cyclopamine. After 24-h treatment in vitro, SHH (5-20 microg/ml) significantly increased cutaneous endothelial NOS protein expression, NOS activity and NO level in normal mice and STZ-induced diabetic mice in a concentration-dependent manner, an effect that was blunted by cyclopamine and NOS inhibitor N(omega)-nitro-L-arginine methyl ester. The phosphatidylinositol 3-kinase inhibitor LY-294002 significantly blunted the increase of NOS activity and NO level induced by SHH treatment in human umbilican vein endothelial cells. These results demonstrate that the SHH pathway is activated in a normal wound, and its reduction results in impaired NO function and wound healing in diabetes. Strategies aimed at augmenting the endogenous SHH pathway may provide an effective means in ameliorating delayed diabetic wound healing.