gebhart/patrepeval huggingface dataset:
Improved 2D time‐of‐flight angiography using a radial‐line <i>k</i>‐space acquisition (1997)

For flow imaging applications, radial-line k-space acquisition methods offer advantages over conventional 2DFT methods. Specifically, radial-line acquisition methods mitigate artifacts resulting from pulsatile flow while offering a potential reduction in scan times. In this paper, radial-line and 2DFT acquisitions are compared in a two-dimensional time-of-flight angiography sequence. The twisting radial-line (TwiRL) trajectory, a variant of 2D projection reconstruction, is used to represent the family of radial-line trajectories. In both phantom and in vivo studies, the TwiRL images demonstrate improved vessel depiction including a more uniform signal intensity and better delineation of the vasculature in comparison with images obtained via the 2DFT method.
Aminoalkanolic derivatives of xanthone with potential antiepileptic activity. (1998)

Synthesis, physicochemical and anticonvulsant properties of some aminoisopropanoloxy derivatives of 2-xanthone are described. The compounds were prepared by the amination of 2-[(2,3-epoxy)-propoxyl]-xanthone or 2-(3-chloro-2-hydroxy-propoxy)-xanthone. The obtained compounds were evaluated for anticonvulsant activity in the maximal electroshock (MES)- and subcutaneous pentylenetetrazole (scMet)-induced seizures and for neurotoxicity in the rotorod test in mice and rats. The most promising compounds seem to be the 3-(tert.-butyl-amino) (3), 3-[N-methyl-(tert.-butyl)-amino] (12) and 3-[4-(benzyl)-1-piperazinyl (5) substituted 2-hydroxy-1-(2-xanthonoxy)-propane from which 3 and 5 were active in both the anticonvulsant tests. The protective index (TD50/ED50) in MES in mice for 3 and valproate, as for 12 and phenytoin or carbamazepine, is similar.
Immune response to native NadA from Neisseria meningitidis and its expression in clinical isolates in Brazil (2003)

A mAb against the NadA protein from Neisseria meningitidis strain 3006 (serosubtype B : 2b : P1.2 : P5.2,8) demonstrated strong bactericidal activity against Brazilian epidemic serogroup B strain N44/89 (B : 4,7 : P1.19,15 : P5.5,7) and a serogroup C strain, IMC 2135 (C : 2a : P1.5,2), but not against another serogroup C strain, N1002/90 (C : 2b : P1.3 : P5.8). The immunogenicity of native NadA in an outer-membrane vesicle (OMV) preparation was also tested. Serum from mice immunized with OMV from serogroup B strain N44/89, which contains the NadA protein, showed bactericidal activity against serogroup B and C strains possessing NadA. In dot-blot analysis of 100 serogroup B and 100 serogroup C isolates from Brazilian patients, the mAb to NadA recognized about 60 % of the samples from both serogroups. The molecular mass of the NadA protein from strain N44/89 determined by mass spectrometry was 37 971 Da and the peptide sequences were identical to those of NadA from N. meningitidis strain MC58.
Efficacy of Strontium Chloride in Dental Hypersensitivity (1987)

Controlled stimuli were used to evaluate a commercially available dentifrice containing 10% strontium chloride hexahydrate for efficacy in alleviating the symptoms of uncomplicated dentinal hypersensitivity. Sixty-one subjects with hypersensitivity were included in the 12-week, double-blind, parallel, comparative (placebo) study. Levels of hypersensitivity in affected teeth were assessed by three methods: thermally controlled cold air stimulus, tactile stimulus with an electronic pressure sensitive probe, and subjective response. The results from all three methods of assessment indicated that the strontium chloride dentifrice, in comparison with a placebo, reduced dentinal hypersensitivity to a significantly greater degree. This therapeutic response to the active agent was apparent within 2 weeks and increased continuously thereafter for the length of the study. One can conclude that the regular at-home use of a dentifrice containing 10% strontium chloride hexahydrate is an effective means for reducing the discomfort and pain engendered by thermal and tactile stimuli in patients with dentinal hypersensitivity.
Nature of intracellular type A botulinum neurotoxin (1981)

The neurotoxin in cells of young Clostridium botulinum type A culture was extracted with lysozyme. Highly purified neurotoxin preparation, obtained by processing the extract in two chromatographic steps had only unnicked (single-chain) molecules of molecular weight comparable to that of the dichains isolated from type A crystals. Trypsinization converted the unnicked molecules into dichains whose component subunits were of sizes indistinguishable from those of the neurotoxin from crystals. The enzymatic treatment increased toxicity of crude extract 30-fold but did not activate the purified intracellular neurotoxin preparation. The results indicated that intracellular type A botulinum neurotoxin is unnicked, is not fully activated, and is activated in the time between its extraction and purification. Since trypsinization nicked all of the single chains without increasing toxicity, nicking was not causally related to toxicity activation.
The effects of mannitol on cerebral edema after large hemispheric cerebral infarct (1999)

Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.
Photoresponsive crown ethers. 8. Azobenzenophane-type switched-on crown ethers which exhibit an all-or-nothing change in ion-binding ability (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoresponsive crown ethers. 8. Azobenzenophane-type switched-on crown ethers which exhibit an all-or-nothing change in ion-binding abilitySeiji Shinkai, Takahide Minami, Yumiko Kusano, and Osamu ManabeCite this: J. Am. Chem. Soc. 1983, 105, 7, 1851–1856Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/ja00345a029https://doi.org/10.1021/ja00345a029research-articleACS PublicationsRequest reuse permissionsArticle Views1180Altmetric-Citations170LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stable lipiodolized emulsions for hepatoma targeting and treatment by transcatheter arterial chemoembolization (1998)

We attempted to develop lipiodolized emulsions that remain in the tumour for a long period, release drug in a sustained release pattern, and thus improve the conventional treatment of hepatocellular carcinoma (HCC) [1]. Polyoxyethylene derivatives of hydrogenated castor oil (HCO) were the most suitable emulsifiers in stabilizing emulsions containing Lipiodol as an oil phase. The length of ethylene oxide coupled to HCO rather than the hydrophilic-lipophilic balance (HLB) values was an important factor in preparing stable emulsions and in achieving sustained-release characteristics. When distilled water was replaced with Iopamiro, a heavy water soluble contrast medium with a specific gravity of 1.335, more stable lipiodolized emulsions with longer sustained release behaviour could be prepared with smaller amount of HCO. To study the in vivo stability of the w/o Lipiodol emulsion and the sustained-release characteristics of doxorubicin from the emulsion, the pharmacokinetic study was performed with normal dogs using transcatheter arterial chemoembolization technique. The area under the plasma concentration-time curve for the first eight hours (AUC0-8) and AUCtotal values of the stabilized emulsion were three to four times higher than those of the coarse emulsion prepared lacking HCO 60. From the in vitro and in vivo studies, Lipiodol based water in oil emulsion with HCO 60 containing doxorubicin showed higher stability and released doxorubicin in a sustained fashion.
Pentraxin 3 overexpression accelerated tumor metastasis and indicated poor prognosis in hepatocellular carcinoma via driving epithelial-mesenchymal transition (2018)

As a pattern recognition receptor, pentraxin 3 (PTX3) has been found to exert the pleiotropic roles on a variety of cancers. However, the accurate clinical significance of PTX3 in hepatocellular carcinoma (HCC) has not been well defined. The aim of the present investigation was to determine the expression characteristics, prognostic significance, and the relevant biological effect of PTX3 in HCC. The expression of PTX3 was evaluated in tumor and adjacent liver tissues from 210 HCC patients using immunohistochemistry staining. And it was found that a marked up-regulation in the expression of PTX3 in the HCC specimens, which was remarkably correlated with high serum AFP level (P = 0.006), larger tumor size (P <0.001), liver cirrhosis (P = 0.004), advanced TNM stage (P = 0.022), PVTT (P = 0.010), intra-hepatic metastases (P = 0.019), and MVI (P <0.001). PTX3 was identified as an independent predictive factor of poor prognosis by multivariate analysis. Ectopic expression of PTX3 enhanced proliferation, migration, invasion capacities of Huh7 cells and induced EMT phenotype. Silencing PTX3 obtained the opposite results. Moreover, the <i>in vivo</i> experiments confirmed PTX3 induced EMT and promoted proliferation and growth of HCC cells. Collectivelly, these data indicated that PTX3 could accelerate HCC progression through activating EMT and served as a potential predictive factor and therapeutic target for HCC.
Quadrotor control for RF source localization and tracking (2014)

Preliminary results on quadrotor control strategies enabling omnidirectional radio frequency (RF) sensing for source localization and tracking are discussed. The use of a quadrotor for source localization and tracking requires a tight coupling of the attitude control and RF sensing designs. We present a controller for tracking a ramp reference input in yaw (causing rotation of quadrotor) while maintaining a constant altitude hover or translation. The ability to track a ramp in the yaw angle is crucial for RF bearing estimation using received signal strength (RSS) measurements from a directional antenna as it avoids the need for additional gimbaling payload. This bearing or angle of arrival (AOA) estimate is then utilized by a particle filter for source localization and tracking. We report on extensive experiments that suggest that this approach is appropriate even in complex indoor environments where multipath fading effects are difficult to model.
The Shaping of a Polyvalent and Highly Individual T-Cell Repertoire in the Bone Marrow of Breast Cancer Patients (2006)

We analyzed the T-cell repertoires from the bone marrow of 39 primary operated breast cancer patients and 11 healthy female donors for the presence and frequencies of spontaneously induced effector/memory T lymphocytes with peptide-HLA-A2-restricted reactivity against 10 breast tumor-associated antigens (TAA) and 3 normal breast tissue-associated antigens by short-term IFN-gamma enzyme-linked immunospot (ELISpot) analysis. Sixty-seven percent of the patients recognized TAAs with a mean frequency of 144 TAA reactive cells per 10(6) T cells. These patients recognized simultaneously an average of 47% of the tested TAAs. The T-cell repertoire was highly polyvalent and exhibited pronounced interindividual differences in the pattern of TAAs recognized by each patient. Strong differences of reactivity were noticed between TAAs, ranging from 100% recognition of prostate-specific antigen(p141-149) to only 25% recognition of MUC1(p12-20) or Her-2/neu(p369-377). In comparison with TAAs, reactivity to normal breast tissue-associated antigens was lower with respect to the proportions of responding patients (30%) and recognized antigens (27%), with a mean frequency of only 85/10(6) T cells. Healthy individuals also contained TAA-reactive T cells but this repertoire was more restricted and the frequencies were in the same range as T cells reacting to normal breast tissue-associated antigens. Our data show a highly individual T-cell repertoire for recognition of TAAs in breast cancer patients. This has potential relevance for T-cell immune diagnostics, for tumor vaccine design, and for predicting immune responsiveness.
Managing context information in mobile devices (2003)

We present a uniform mobile terminal software framework that provides systematic methods for acquiring and processing useful context information from a user's surroundings and giving it to applications. The framework simplifies the development of context-aware mobile applications by managing raw context information gained from multiple sources and enabling higher-level context abstractions.
21-21 (2022)

The paper presents the transmission spectra of hybrid perovskite MAPbI3 single crystals near the fundamental absorption edge in a wide temperature range. The absorption coefficient α of the single crystal samples is estimated at a temperature T = 150 K for the light with a photon energy E = 1.6 eV and at T = 40 K for E = 1.8 eV. The obtained values turned out to be several orders of magnitude smaller than the values of α for thin-film samples known from the literature. A sharp shift of the fundamental absorption edge by ~ 100 meV was observed at a temperature T1 = 160 K of the structural phase transition from the tetragonal to the orthorhombic phase. The temperature hysteresis of the shift of the fundamental absorption edge near T1 was recorded, which is characteristic of a first-order phase transition.
Silicon‐containing liquid polymer electrolytes for application in lithium ion batteries (2009)

Abstract Since the initial discovery of poly(ethylene glycol) (PEG) as a good lithium ion conductor at elevated temperatures, efforts have been made to find ways of incorporating this biocompatible polymer into lithium ion batteries. In areas of research involving implantable medical devices, consumer electronics and automotive power sources, there is a need to develop a ‘safe’ alternative to the solvent‐based, flammable and toxic electrolytes currently employed. However, PEG has been shown to be electrochemically unstable and crystalline at room temperature. In order to overcome these problems, polysiloxanes have been conjugated to PEG in order to improve its conductivity and physical properties. Over the last few years, the group at the University of Wisconsin‐Madison has been involved in collaborations with scientists at Argonne National Laboratories, Grinnell College and Quallion LLC to develop commercially viable silicon‐containing polymer electrolytes. This mini‐review discusses the electrochemical, thermal and physical properties of these electrolytes, and highlights the progress from high molecular weight polysiloxane‐based electrolytes to low‐viscosity, highly conducting oligosiloxane and silane electrolytes. Copyright © 2009 Society of Chemical Industry
Addition of IFN-α to Treatment of Malignant Brain Tumors (1994)

Despite many attempts to improve the survival after surgery of patients with malignant astrocytoma the prognosis is poor. We have used natural IFN-alpha in 16 patients with malignant astrocytoma treated between 1987 and 1990; 6 for recurrent tumors. Radiation therapy was given in 2 Gy fractions daily to a total dose of 50 Gy in the tumor area, 5 fractions per week and IFN twice per week, cisplatinum 60 mg/m2 i.v. every second week and vincristine 2 mg every week in 12-h i.v. infusions. Eight patients were reoperated when clinical deterioration suggested recurrent tumor; histological examination showed no residual tumor in 7 of them. Of these 8 patients 3 are alive and well, 2 of them after more than 5 years. The study suggests that malignant astrocytoma can be successfully eradicated with surgery, irradiation, IFN-alpha and chemotherapy. The treatment had, however, unacceptably high neurotoxicity. Earlier removal of the tumor necrosis, before clinical deterioration, could possibly diminish the high complication rate and consequently improve survival.
Binary tree classifier and context classifier (1985)

Two methods of designing a point classifier are discussed in this paper, one is a binary decision tree classifier based on the Fisher's linear discriminant function as a decision rule at each nonterminal node, and the other is a contextual classifier which gives each pixel the highest probability label given some substantially sized context including the pixel. Experiments were performed both on a simulated image and real images to illustrate the improvement of the classification accuracy over the conventional single-stage Bayes classifier under Gaussian distribution assumption.
Comparison of Classic DC/DC Converters with Converters Equipped with Analog-Digital Regulator Based on Law of Conservation of Energy (Bumblebee Type) (2007)

In the paper verification of new DC/DC converters control method, designed by authors with use of law of conservation of energy is presented. A comparison was made between classic DC/DC converters used widely in industry (for comparison LT1074 Linear Technology device was chosen), with converters equipped with analog-digital controller designed by authors. Results of conducted simulation research confirmed superior parameters of proposed solution when compared to classic converters, and much better immunity to changes in loads resistance. Both solutions have similar static parameters. Proposed method is an attractive alternative for actual DC/DC converters control methods.
The Research of Exploring Digital Learning Material Use Behavior Based on Technology Acceptance Model: English Assessment Curriculum as an Example (2007)

The purpose of this research is based on technology acceptance model(TAM) to explore ”characteristics of digital learning material” and ”Interaction of digital learning between classmates” -how the students come to accept the technology and the degree of influence. It helps us to understand how students using the system of digital learning materials to further improve their curriculum outcome. This research is targeted on a group of high school students who study the English Assessment Curriculum. From that aspect of research, we inputted digital learning materials to the technology acceptance model. We used questionnaires as a survey method to collect information, and SPSS statistical formula as instrument to process information on a statistics analysis, reliability analysis and factor analysis-to confirm the motive of students' behavior on using digital learning materials. This time we have done 100 questionnaires, and 93 questionnaires were valid. The result of this research has demonstrated the correlations of each hypothesis were all above level, which has significantly indicated most of students were able to use the digital learning materials to improve their learning motive. To achieve the learning aim is by using the advantage of digital learning materials, i.e. repetitious practice, to facilitate students of a lack on curriculum learning.
Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption (2007)

Inhibitory effects of apple polyphenol extract (AP) and procyanidin contained in AP on in vitro pancreatic lipase activity and in vivo triglyceride absorption in mice and humans were examined. AP and procyanidin considerably inhibited in vitro pancreatic lipase activity. However, polyphenols, except for procyanidin, in AP (i.e., catechins, chalcones, and phenol carboxylic acids) showed weak inhibitory activities on pancreatic lipase. Procyanidins separated by normal-phase chromatography according to the degree of polymerization were also examined. Inhibitory effects of procyanidins increased according to the degree of polymerization from dimer to pentamer. On the other hand, pentamer or greater procyanidins showed maximal inhibitory effects on pancreatic lipase. These results suggested that with respect to in vitro pancreatic lipase inhibition, the degree of polymerization was an important factor and oligomeric procyanidin mainly contributed. Next, we performed a triglyceride tolerance test in mice and humans. Simultaneous ingestion of AP and triglyceride significantly inhibited an increase of plasma triglyceride levels in both models. These results suggested that the oligomeric procyanidins contained in AP inhibited triglyceride absorption by inhibiting pancreatic lipase activity in mice and humans.
Organisational influences on management accounting toolkits in Chinese enterprises: an exploratory study (2018)

The purpose of this paper is to investigate Chinese management accounting practice regarding the question whether enterprises use a common set of management accounting instruments. In addition, the study explores the influence of selected organisational variables on the adoption of specific management accounting practices (MAPs). It utilises a Mandarin-language online survey of key actors and evaluates selected information from personal interviews with CFOs in Mainland China. The research finds no evidence of a common mix of management accounting tools in the sample of Chinese enterprises under investigation. However, the study does demonstrate that organisational variables have a significant impact on specific management accounting tools.
Flexible Data-rate and Reach Transmission Employing Hybrid Modulation and Scrambled Coherent Superposition (2017)

Subcarrier multiplexing hybrid QAM combined with coherent superposition is proposed to achieve flexibility in spectral efficiency (SE) and reach. Experimental evaluation over SSMF shows scalable SE from 4.9 to 1.2 bit/s/Hz with maximum reach from 2000 to 15500 km, respectively.
The effect of biofilm permeability on bio‐clogging of porous media (2011)

A 3D Biofilm model, appropriate for complex porous media support structures, is successfully modified such that non-zero permeability of biofilms structures is enabled. A systematic study is then conducted into the influence of biofilm permeability on overall biomass growth rate. This reveals a significant influence at large biofilm concentrations; even when the permeability of the biomass is 1.25% of that of the free pore space, biomass accumulation increased by a factor of ∼3 over 40 h. The effect is shown to be retained when allowing for biomass detachment or erosion as a consequence of adjacent velocity shear. We conclude that biofilm permeability should be included in biofilm models and that further experimental work is required to better describe the link between biofilm permeability and local microstructure.