gebhart/patrepeval huggingface dataset:
Bed mobility task performance in older adults. (2001)

Difficulty in transferring, the ability to rise in and out of a bed and chair, is a common problem in older adults, particularly those residing in skilled nursing facilities. Focusing on one aspect of transferring, rising from supine to sitting position, we devised a set of bed mobility tasks to test key arm, leg, and trunk movements that likely contribute to successful rising from bed. Healthy young controls (YC, n=22, mean age 23), and older adults (aged 60 and over) either residing independently in congregate housing (CH, n=29, mean age 84) or undergoing rehabilitation in a skilled nursing facility (SNF, mean age 77) were assessed in the time to rise from supine to sitting and in the ability or inability to perform 16 other bed mobility tasks. Trunk function-related tasks, specifically those requiring trunk elevation and trunk balance, were most difficult for the SNF, followed by CH, and then YC. Tasks focusing on trunk flexion strength (sit up arms crossed, bilateral heel raise) and lateral trunk strength/balance were the most difficult for both SNF and CH, although there was minimal difference in the percent unable to complete each task. The major CH-SNF differences occurred in trunk elevation tasks where the upper limb was important in facilitating trunk elevation (sit up with head of bed elevation with use of arms, sit up with the use of a trapeze, or sit up with use of arms from a flat bed position). These findings suggest that to improve frail older adult performance on bed mobility tasks, and specifically in rising from supine to sitting, training should move beyond improving trunk function (i.e., trunk strength). There should be an additional focus, either through therapy or bed design modifications, on how upper limb movements and positioning can be used to assist in trunk elevation.
CREA LA FES CUAUTITL N SERVICIO SOCIAL DE AYUDA A MIGRANTES EN EU (2011)

CON EL LEMA: POR TI, ES POR TU BIENESTAR, ALUMNOS DE LA LICENCIATURA DE DISENO Y COMUNICACION VISUAL DE LA FACULTAD DE ESTUDIOS SUPERIORES CUAUTITL N, COMO SERVICIO SOCIAL, INICIARON UNA CAMPANA DE PREVISION DE ENFERMEDADES EN BENEFICIO DE LOS MIGRANTES LATINOS EN ESTADOS UNIDOS. ESTO FUE POSIBLE CON EL APOYO DE LA ORGANIZACION CIVIL INICIATIVA DE SALUD DE LAS AM‚RICAS (ISA), QUE SE OCUPA DEL BIENESTAR DE ESE GRUPO Y CUENTA CON LA COLABORACION DE CIUDADANOS DE COLOMBIA, ECUADOR, EL SALVADOR, GUATEMALA, HONDURAS, PER£ Y MEXICO. COMO DEL PROGRAMA DE MOVILIDAD ESTUDIANTIL DE CUAUTITL N, AUSPICIADO POR LA DIRECCION GENERAL DE COOPERACION E INTERNACIONALIZACION DE LA UNAM, XOCHITL NASHIELLY ZAGAL RAMIREZ, DEL S‚PTIMO SEMESTRE DE DISENO, FUE SELECCIONADA PARA ASISTIR AL CONGRESO SUMMER INSTITUTE ON MIGRATION AND GLOBAL HEALTH, ORGANIZADO POR ISA EN LA UNIVERSIDAD DE CALIFORNIA, EN BERKELEY. POR SU LABOR DESTACADA, LA AGRUPACION SOLICITO LA COLABORACION DE UN EQUIPO DE TRABAJO CONFORMADO POR ALUMNOS DE LA UNIVERSIDAD NACIONAL. ENTONCES SE REGISTRO EN EL DEPARTAMENTO DE ORIENTACION DE LA ENTIDAD UNIVERSITARIA EL PROGRAMA DE SERVICIO SOCIAL CREACION DE CAMPANAS DE COMUNICACION PARA LA PROMOCION DE LA SALUD ENTRE LAS COMUNIDADES DE MIGRANTES LATINOS EN ESTADOS UNIDOS, EN EL QUE PARTICIPAN NUEVE ESTUDIANTES DE LA LICENCIATURA MENCIONADA Y UNO MAS DE LA UNIVERSIDAD DEL VALLE DE MEXICO, QUIEN REALIZA PR CTICAS PROFESIONALES. ZAGAL RAMIREZ EXPLICO: PARTE DE NUESTRO TRABAJO SIRVIO PARA PROMOCIONAR LA XI BINATIONAL HEALTH WEEK, DONDE SE ATENDIERON CUATRO AREAS ESPECIFICAS: SALUD DE LA MUJER (C NCER DE MAMA Y CERVICOUTERINO, PREVENCION DE EMBARAZOS EN ADOLESCENTES Y DE VIOLENCIA DOM‚STICA), ENFERMEDADES CRONICAS (DIABETES Y OBESIDAD), ENFERMEDADES INFECCIOSAS (VIH/SIDA Y TUBERCULOSIS), Y SALUD MENTAL (DEPRESION Y ANSIEDAD). EL PLAN DE SERVICIO SOCIAL BRINDA APOYO A LOS PROGRAMAS DE ISA Y PRODUCE CAMPANAS MEDI TICAS.
PN offset planning strategies for non-uniform CDMA networks (2002)

This paper presents a novel methodology in planning the PN-offsets of a highly non-uniform CDMA network and discusses the major related issues. The strategy is applicable to any real life PCS and cellular networks. It is shown that by optimally choosing/arranging parameters, it is not only possible to mitigate the co- and adjacent PN-offset interferences, sufficient PN-offset values can also be reserved for new cells to be added into existing clusters for future network development.
Cancer Vaccines Co-Targeting HER2/Neu and IGF1R (2019)

(1) Background: Human epidermal growth factor receptor 2 (HER2)/neu-driven carcinogenesis is delayed by preventive vaccines able to elicit autochthonous antibodies against HER2/neu. Since cooperation between different receptor tyrosine kinases (RTKs) can occur in human as well as in experimental tumors, we investigated the set-up of DNA and cell vaccines to elicit an antibody response co-targeting two RTKs: HER2/neu and the Insulin-like Growth Factor Receptor-1 (IGF1R). (2) Methods: Plasmid vectors carrying the murine optimized IGF1R sequence or the human IGF1R isoform were used as electroporated DNA vaccines. IGF1R plasmids were transfected in allogeneic HER2/neu-positive IL12-producing murine cancer cells to obtain adjuvanted cell vaccines co-expressing HER2/neu and IGF1R. Vaccination was administered in the preneoplastic stage to mice prone to develop HER2/neu-driven, IGF1R-dependent rhabdomyosarcoma. (3) Results: Electroporated DNA vaccines for murine IGF1R did not elicit anti-mIGF1R antibodies, even when combined with Treg-depletion and/or IL12, while DNA vaccines carrying the human IGF1R elicited antibodies recognizing only the human IGF1R isoform. Cell vaccines co-expressing HER2/neu and murine or human IGF1R succeeded in eliciting antibodies recognizing the murine IGF1R isoform. Cell vaccines co-targeting HER2/neu and murine IGF1R induced the highest level of anti-IGF1R antibodies and nearly significantly delayed the onset of spontaneous rhabdomyosarcomas. (4) Conclusions: Multi-engineered adjuvanted cancer cell vaccines can break the tolerance towards a highly tolerized RTK, such as IGF1R. Cell vaccines co-targeting HER2/neu and IGF1R elicited low levels of specific antibodies that slightly delayed onset of HER2/neu-driven, IGF1R-dependent tumors.
Alkaline protease deficiency in the cr-1 (crisp) mutant of Neurospora crassa. (1986)

The adenyl cyclase deficient cr-1 mutant of Neurospora crassa grew poorly in bovine serum albumin as an alternative and only source of either sulfur, nitrogen or carbon. The low growth of the cr-1 mutant in protein was correlated with limited secretion of extracellular alkaline protease. The defect was specific for the cr-1 mutant and was suppressed by exogenous cyclic AMP. Cyclic AMP relieved protease deficiency under carbon, nitrogen or sulfur limiting conditions to unequal extents. Protease stimulation was greatest under carbon-limited conditions, but the resulting growth was least. Most of the cyclic AMP-mediated increase of alkaline protease was extracellular.
Identification of Trichomonas vaginalis Cysteine Proteases That Induce Apoptosis in Human Vaginal Epithelial Cells (2005)

A secreted cysteine protease (CP) fraction from Trichomonas vaginalis is shown here to induce apoptosis in human vaginal epithelial cells (HVEC) and is analyzed by mass spectrometry. The trichomonad parasite T. vaginalis causes one of the most common non-viral sexually transmitted infection in humans, trichomoniasis. The parasite as well as a secreted cysteine protease (CP) fraction, isolated by affinity chromatography followed by Bio-Gel P-60 column chromatography, are shown to induce HVEC apoptosis, as demonstrated by the Cell Death Detection ELISA(PLUS) assay and annexin V-fluorescein isothiocyanate flow cytometry analyses. Initiation of apoptosis is correlated with protease activity because the specific CP inhibitor E-64 inhibits both activities. SDS-PAGE analysis of the CP fraction reveals triplet bands around 30 kDa, and matrix-assisted laser desorption ionization time-of-flight MS indicates two closely associated peaks of molecular mass 23.6 and 23.8 kDa. Mass spectral peptide sequencing of the proteolytically digested CPs results in matches to previously reported cDNA clones, CP2, CP3, and CP4 (Mallinson, D. J., Lockwood, B. C., Coombs, G. H., and North, M. J. (1994) Microbiology 140, 2725-2735), as well as another sequence with high homology to CP4 (www.tigr.org). These last two species are the most abundant components of the CP fraction. The present results, suggesting that CP-induced programmed cell death may be involved in the pathogenesis of T. vaginalis infection in vivo, may have important implications for therapeutic intervention.
Inheritance Properties of Role Hierarchies (1998)

Abstract: Role Based Access Control (RBAC) refers to a class of security mechanisms that mediate access to resources through organizational identities called roles. A number of models have been published [1, 2,3] that formally describe the basic properties of RBAC. One feature of these models is the notion of a role hierarchy, which represents the relationship among roles that are defined in terms of other roles and inherit basic capabilities from them. This paper explores some interesting characteristics of role hierarchies and how they affect basic RBAC properties such as separation of duty.
Vasculopathy, inflammation, and blood flow in leg ulcers of patients with sickle cell anemia (2013)

Chronic leg ulcers are frequent and debilitating complications of sickle cell anemia. Inadequate blood supply has been postulated to be an important factor in their occurrence and delayed healing. Little is known about their microcirculatory and histopathological changes. We evaluated the microcirculation of lower extremity ulcers with laser speckle contrast imaging and infrared thermography and obtained clinical and laboratory characteristics in 18 adults with sickle cell anemia and chronic leg ulcers. Skin biopsies were obtained in four subjects. Subjects had markers of severe disease, anemia, high degree of hemolysis, inflammation, and thrombophilia. The highest blood flow was present in the ulcer bed, progressively less in the immediate periwound area, and an unaffected control skin area in the same extremity. Microscopic examination showed evidence of venostasis, inflammation, and vasculopathy. Blood vessels were increased in number, had activated endothelium and evidence of thrombosis/recanalization. High blood flow may be due to chronic inflammation, cutaneous vasodilatation, venostasis, and in situ thrombosis. These changes in skin microcirculation are similar to chronic venous ulcers in the non-sickle cell disease (SCD) population, thus suggesting that leg ulcers may be another end-organ complication with endothelial dysfunction that appears in patients with SCD at a younger age and with higher frequency than in the general population.
Mantle cell lymphoma (2010)

Since its addition to the Revised European–American Lymphoma classification, in 1994, mantle cell lymphoma (MCL) has been recognized as carrying both features of indolent lymphoma (incurable) and a more aggressive course with short response to standard chemotherapy and common chemoresistance over time leading to very poor long-term prognosis. The disease presents typically in the elderly male population, with advanced-stage and constant extranodal involvement. There is still no consensus in the treatment of MCL; dose-intensification approaches with or without stem cell transplantation are commonly used in younger patients (< 65 years), though unfortunately patients still relapse over time. In the relapsed setting, the field is marked by the development of a large number of novel agents, especially biologicals or targeted therapies. The integration of these new agents to frontline conventional therapies will hopefully improve patients' outcome. On the other hand, evidence is mounting on the complexity and heterogeneity of MCL, which might be best described as a spectrum of diseases (based essentially on the degree of proliferation). The landmark t(11;14)(q13;q32) translocation, responsible for cyclin D1 overexpression, is in virtually all cases accompanied by additional secondary genomic alterations (genomic instability), which vary among patients and strongly impact clinical course and prognosis. Though the overall survival seems to have improved (doubled) in the last three decades, a better stratification of patients is needed as well as an effort for participation in clinical trials.
FACTORS AFFECTING ANTIBLOCK PERFORMANCE OF ETHYLENE VINYL ACETATE COPOLYMERS (1995)

The antiblock performance of fatty amides was investigated in ethylene vinyl acetate (EVA) copolymers (VA = 28 wt% and MI = 400 g/10 minutes) and in low density polyethylene (LDPE). This investigation was done in an attempt to optimize the conditions for bulk shipments of these polymers in warm weather. Factors affecting the antiblock characteristics such as base resin, amide type, amide concentration, time and temperature were studied. Several analytical techniques were used including ATR-FTIR (both isothermal and non-isothermal in-situ measurements), HPLC, coefficient of friction (COF), stick temperature and dielectric constant measurement. The results indicate that the main mechanisms controlling amide antiblock performance are its ability to migrate to the polymer surface and its incompatibility with the polymer matrix.
Robustness of Random Forest-based gene selection methods (2014)

The post-selection classifier error rate, which is a frequently used measure, was found to be a potentially deceptive measure of gene selection quality. When the number of consistently selected genes was considered, the Boruta algorithm was clearly the best. Although it was also the most computationally intensive method, the Boruta algorithm's computational demands could be reduced to levels comparable to those of other algorithms by replacing the Random Forest importance with a comparable measure from Random Ferns (a similar but simplified classifier). Despite their design assumptions, the minimal optimal selection methods, were found to select a high fraction of false positives.
Very fast CRISPR on demand (2020)

CRISPR-Cas systems provide versatile tools for programmable genome editing. Here, we developed a caged RNA strategy that allows Cas9 to bind DNA but not cleave until light-induced activation. This approach, referred to as very fast CRISPR (vfCRISPR), creates double-strand breaks (DSBs) at the submicrometer and second scales. Synchronized cleavage improved kinetic analysis of DNA repair, revealing that cells respond to Cas9-induced DSBs within minutes and can retain MRE11 after DNA ligation. Phosphorylation of H2AX after DNA damage propagated more than 100 kilobases per minute, reaching up to 30 megabases. Using single-cell fluorescence imaging, we characterized multiple cycles of 53BP1 repair foci formation and dissolution, with the first cycle taking longer than subsequent cycles and its duration modulated by inhibition of repair. Imaging-guided subcellular Cas9 activation further facilitated genomic manipulation with single-allele resolution. vfCRISPR enables DNA-repair studies at high resolution in space, time, and genomic coordinates.
Enzymatic Production of Non‐Natural Nucleoside‐5′‐Monophosphates by a Thermostable Uracil Phosphoribosyltransferase (2017)

Abstract The use of enzymes as biocatalysts applied to synthesis of modified nucleoside‐5′‐monophosphates (NMPs) is an interesting alternative to traditional multistep chemical methods which offers several advantages, such as stereo‐, regio‐, and enantioselectivity, simple downstream processing, and mild reaction conditions. Herein we report the recombinant expression, production, and purification of uracil phosphoribosyltransferase from Thermus themophilus HB8 ( Tt UPRT). The structure of Tt UPRT has been determined by protein crystallography, and its substrate specificity and biochemical characteristics have been analyzed, providing new structural insights into the substrate‐binding mode. Biochemical characterization of the recombinant protein indicates that the enzyme is a homotetramer, with activity and stability across a broad range of temperatures (50–80 °C), pH (5.5–9) and ionic strength (0–500 m m NaCl). Surprisingly, Tt UPRT is able to recognize several 5 and 6‐substituted pyrimidines as substrates. These experimental results suggest Tt UPRT could be a valuable biocatalyst for the synthesis of modified NMPs.
The Pharmacology Of Carnitine (1987)

Due to the massive data sets available for drug candidates, modern drug discovery has advanced to the big data era. Central to this shift is the development of artificial intelligence approaches to implementing innovative modeling based on the dynamic, ...Read More
Posttranscriptional effect of insulin-like growth factor-I on interleukin-1beta-induced type II-secreted phospholipase A2 gene expression in rabbit articular chondrocytes. (1997)

Large amounts of type II-secreted phospholipase A2 (type II sPLA2) are secreted into inflammatory synovial fluid and they are believed to induce the synthesis of lipid mediators by articular chondrocytes. Preliminary experiments showed that insulin-like growth factor-I, which counteracts cartilage degradation in arthritis, inhibits interleukin-1beta-induced type II sPLA2 gene expression in rabbit articular chondrocytes (Berenbaum, F., G. Thomas, S. Poiraudeau, G. Bereziat, M.T. Corvol, and J. Masliah. 1994. FEBS Lett. 340: 51-55). The present study showed that IL-1beta induced the sustained synthesis of prostaglandin E2 and a parallel increase in type II sPLA2 gene expression (assessed by enzymatic activity and Northern blot analysis), but no increase in cytosolic PLA2 gene expression (assessed by Northern and Western blot analysis) or cytosolic PLA2 activity in rabbit articular chondrocytes. IGF-I inhibited both IL-1beta-stimulated PGE2 synthesis and type II sPLA2 gene expression, but had no effect on cytosolic PLA2 gene expression. Nuclear run-on experiments revealed that IL-1beta stimulated the transcription rate of type II sPLA2 gene, giving rise to long-lived mRNA in cells treated with actinomycin D. IGF-I did not affect transcription rate, suggesting that it acts as a post-transcriptional step. Sucrose density gradient analysis of the translation step showed no effect of IGF-I on the entry of type II sPLA2 mRNA into the polysomal pool or on its distribution into the various polysomal complexes, suggesting that IGF-I does not act on the translation of the mRNA. Lastly, IGF-I strongly decreased the half-life of IL-1beta-induced type II sPLA2 mRNA (from 92 to 12 h), suggesting that IGF-I destabilizes mRNA. These data demonstrate that IL-1beta stimulates the transcription rate of the type II sPLA2 gene and gives rise to a very stable mRNA. In contrast, IGF-I decreases the half-life of the type II sPLA2 message.
Multi-objective Parameters Optimization for HEV Based on improved Particle Swarm Algorithm (2019)

Hybrid electric vehicle fuel consumption and emissions are closely related to its energy management strategy. A fuzzy controller of energy management using vehicle torque request and battery state of charge (SOC) as inputs, engine torque as output is designed in this paper foe parallel hybrid electric vehicle. And a multi-objective mathematical function which purpose on maximize fuel economy and minimize emissions is also established, in order to improve the adaptive ability and the control precision of basic fuzzy controller, this paper proposed an improved particle swarm algorithm that based on dynamic learning factor and adaptive inertia weight to optimize the control parameters. Simulation results based on ADVISOR software platform show that the optimized energy management strategy has a better distribution of engine and motor torque, which helps to improved the vehicle’s fuel economy and exhaust emission performance.
A constrained optimization framework for compliant underactuated grasping (2011)

Abstract. This study focuses on the design and analysis of underactuated robotic hands that use tendons and compliant joints to enable passive mechanical adaptation during grasping tasks. We use a quasistatic equilibrium formulation to predict the stability of a given grasp. This method is then used as the inner loop of an optimization algorithm that can find a set of actuation mechanism parameters that optimize the stability measure for an entire set of grasps. We discuss two possible approaches to design optimization using this framework, one using exhaustive search over the parameter space, and the other using a simplified gripper construction to cast the problem to a form that is directly solvable using well-established optimization methods. Computations are performed in 3-D, allow arbitrary geometry of the grasped objects and take into account frictional constraints. This paper was presented at the IFToMM/ASME International Workshop on Underactuated Grasping (UG2010), 19 August 2010, Montréal, Canada.
Important Considerations in Matrix Stimulation Candidate Selection in Niger Delta (2009)

ABSTRACT Matrix stimulation improves well productivity through the removal of formation damage in the near-wellbore region of the reservoir. Success and failure of stimulation treatments are often attributable to candidate selection. Lack of a structured approach to candidate selection has had an adverse effect on the outcome of stimulation treatments industry-wide. Where good candidates have been identified, the absence of robust techniques for the determination of damage radius introduces uncertainty on the accurate volume of treatment fluid to deploy. This paper presents a robust approach to candidate selection based on analysis of the relative impact of various skin effects in the well. Simple mathematical expressions that describe the relative impact of formation damage and partial penetration were also derived. A novel approach for the determination of damage radius is also introduced. The damage radius so determined is considered useful for accurate calculation of matrix treatments volumes.
A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency (2015)

Sebelipase alfa therapy resulted in a reduction in multiple disease-related hepatic and lipid abnormalities in children and adults with lysosomal acid lipase deficiency. (Funded by Synageva BioPharma and others; ARISE ClinicalTrials.gov number, NCT01757184.).