gebhart/patrepeval huggingface dataset:
Interconnecting Cisco network devices. (2007)

From the Book:
In April 1998, Cisco Systems, Inc., announced a new professional development initiative called the Cisco Career Certifications. These certifications address the growing worldwide demand for more (and better) trained computer networking experts. Building upon our highly successful Cisco Certified Internetwork Expert (CCIE) programthe industry's most respected networking certification vehicle-Cisco Career Certifications enable you to be certified at various technical proficiency levels. Interconnecting Cisco Network Devices presents, in book format, all the topics covered in the challenging instructor-led and e-learning certification preparation courses of the same name. The ICND courses are the latest iteration of the CCNA recommended training material previously covered in Introduction to Cisco Router Configuration (ICRC 11.3) and Cisco Routers and LAN Switches (CRLS 3.0), as well as a portion of Cisco LAN Switch Configuration (CLSC). Whether you are studying to become CCNA certified or you just need a better understanding of the concepts, commands, and practices required to configure Cisco switches and routers in multiprotocol networks, you will benefit from the information presented in this book. Cisco and Cisco Press present this material in text-based format to provide another learning vehicle for our customers and the broader user community in general. Although a publication does not duplicate the instructor-led or e-learning environments, we acknowledge that not everyone responds in the same way to the same delivery mechanism. It is our intent that presenting this material via a Cisco Press publication will enhance the transfer of knowledge to a broad audience of networkingprofessionals. This is the seventh in a series of course supplements planned for Cisco Press, following Introduction to Cisco Router Configuration, Advanced Cisco Router Configuration, Building Cisco Remote Access Networks, Cisco Internetwork Troubleshooting, Designing Cisco Networks, and Cisco Internetwork Design. Cisco will present existing and future courses through these coursebooks to help achieve Cisco Worldwide Training's principal objectives: to educate the Cisco community of networking professionals and to enable that community to build and maintain reliable, scalable networks. The Cisco Career Certifications and classes that support these certifications are directed at meeting these objectives through a disciplined approach to progressive learning. The books Cisco creates in partnership with Cisco Press will meet the same standards for content quality demanded of our courses and certifications. It is our intent that you will find this and subsequent Cisco Press certification and training publications of value as you build your networking knowledge base.
A Computationally Designed DNA Aptamer Template with Specific Binding to Phosphatidylserine (2013)

The phospholipid phosphatidylserine (PS) is an early marker exploited for detecting apoptosis (PS externalization in the cell membrane bilayer) and one factor that is associated with increased amyloid plaque deposition in transmissible spongiform encephalopathies (TSEs). PS can therefore be considered as a promising target for diagnosis or treatment of diseases. Aptamers (short nucleic acid sequences) are a particularly attractive class of materials among those currently considered for targeting PS. Here we applied an entropy based seed-and-grow strategy to design a DNA aptamer template to bind specifically to PS. The binding properties of designed aptamers were investigated computationally and experimentally. The studies identify the sequence, 5'-AAAGAC-3', as the preferred template for further modifications and studies toward its practical implementations.
Growth Characteristics of Myelodysplastic CD34<sup>+</sup>Cells (1998)

Myelodysplastic syndromes (MDS) are a heterogeneous group of disorders of hematopoiesis entailing hyperproliferative and ineffective hematopoiesis associated with morphologic evidence of marrow cell dysplasia resulting in refractory cytopenia(s), and an increased risk of transformation into acute myeloblastic leukemia (AML). The administration of colony-stimulating factor(s) (CSFs) to patients with MDS increased blood neutrophil concentrations, in most patients, and it was anticipated to be of benefit to prevent infections. The progression to AML while being treated with CSFs has come under close scrutiny. In vitro studies are expected to produce more pertinent criteria for selection of patients who are likely to benefit, as well as the overall benefits of various therapies. For this purpose, in vitro colony assays are an excellent approach for investigation of the biologic characteristics of MDS progenitor cells. The stem cell phenotype CD34 is the one of the best markers of progenitor cells, and can be used for the purification of these cells to unify levels of maturation; a direct comparison of proliferative and differentiative capacity of MDS progenitor cells with normal CD34+ cells can thus be made. The properties of MDS CD34+ cells are described here in association with proliferation and differentiation, with special emphasis on the role of stem cell factor (a ligand for c-kit) in leukemic type growth of MDS CD34+ cells.
Aptamer selection for the detection of<i>Escherichia coli</i>K88 (2011)

In this study, the first group of single-stranded DNA aptamers that are highly specific to enterotoxigenic Escherichia coli (ETEC) K88 was obtained from an enriched oligonucleotide pool by the SELEX (Systematic Evolution of Ligands by Exponential Enrichment) procedure, during which the K88 fimbriae protein was used as the target and bovine serum albumin as counter targets. These aptamers were applied successfully in the detection of ETEC K88. They were then grouped under different families based on the similarity of their secondary structure and the homology of their primary sequence. Four sequences from different families were deliberately chosen for further characterization by fluorescence analysis. Having the advantage of high sensitivity, fluorescence photometry was selected as single-stranded DNA quantification method during the SELEX process. Aptamers with the highest specificity and affinity were analyzed to evaluate binding ability with E. coli. Since ETEC K88 is the only type of bacterium that expressed abundant K88 fimbriae, the selected aptamers against the K88 fimbriae protein were able to specifically identify ETEC K88 among other bacteria. This method of detecting ETEC K88 by aptamers can also be applied to bacteria other than ETEC K88.
Morphological Stability of the Initially Formed Polymer Particles in Stopped-Flow Propylene Polymerization (2010)

The morphological stability of initially formed polymer particles against air was improved in order to study the initial morphology development with Zigler-Natta catalyst olefin polymerization. The stopped-flow polymerization technique was applied to synthesize initial polymer particles in combination with various quenching and stabilizing procedures. When polymerizing particles were quenched with cold heptane maintained at -65°C under N_2 or CO_2, the exposure of the formed particles to air caused the fast formation of cracks on the surface, leading to serious reformation of the particle shape. However, when the particles were quenched with cold heptane under CO_2 and washed with heptane containing an appropriate amount oftetrahydrofuran, the particle morphology was significantly stabilized which hardly changed even after 1 h exposure to air. The established stabilizing procedure is highly useful for various characterizations of the initially formed particles.
Measurement and analysis of results obtained on biological substances with differential scanning calorimetry (IUPAC Technical Report) (2001)

Abstract Differential scanning calorimeters (DSCs) have been widely used to determine the thermodynamics of phase transitions and conformational changes in biological systems including proteins, nucleic acid sequences, and lipid assemblies. DSCs monitor the temperature difference between two vessels, one containing the biological solution and the other containing a reference solution, as a function of temperature at a given scan rate. Recommendations for DSC measurement procedures, calibration procedures, and procedures for testing the performance of the DSC are described. Analysis of the measurements should include a correction for the time response of the instrument and conversion of the power vs. time curve to a heat capacity vs. temperature plot. Thermodynamic transition models should only be applied to the analysis of the heat capacity curves if the model-derived transition temperatures and enthalpies are independent of the DSC scan rate. Otherwise, kinetic models should be applied to the analysis of the data. Application of thermodynamic transition models involving two states, two states and dissociation, and three states to the heat capacity vs. temperature data are described. To check the operating performance with standard DSCs, samples of 1 to 10 mg mL ­1 solutions of hen egg white lysozyme in 0.1 M HCl-glycine buffer at pH = 2.4 ± 0.1 were sent to six different DSC laboratories worldwide. The values obtained from proper measurements and application of a two-state transition model yielded an average unfolding transition temperature for lysozyme of 331.2 K with values ranging from 329.4 to 331.9 K, and an average transition enthalpy of 405 kJ mol ­1 with values ranging from 377 to 439 kJ mol ­1 . It is recommended that the reporting of DSC results be specific with regard to the composition of the solution, the operating conditions and calibrations of the DSC, determination of base lines that may be model-dependent, and the model used in the analysis of the data.
Exosomes for Diagnosis and Therapy in Gastrointestinal Cancers (2020)

Exosomes are membrane-bound extracellular vesicles (EVs) released by most cells, having a size ranging from 30 to 150 nm, and are involved in mechanisms of cell-cell communication in physiological and pathological tissues. Exosomes are engaged in the transport of biomolecules, such as lipids, proteins, messenger <i>RNAs</i>, and micro<i>RNA</i>, and in signal transmission through the intercellular transfer of components. In the context of proteins and nucleic acids transported from exosomes, our interest is focused on the Frizzled proteins family and related messenger <i>RNA</i>. Exosomes can regenerate stem cell phenotypes and convert them into cancer stem cells by regulating the Wnt pathway receptor family, namely Frizzled proteins. In particular, for gastrointestinal cancers, the Frizzled protein involved in those mechanisms is Frizzled-10 (FZD-10). Currently, increasing attention is being devoted to the protein and lipid composition of exosomes interior and membranes, representing profound knowledge of specific exosomes composition fundamental for their application as new delivering drug tools for cancer therapy. This review intends to cover the most recent literature on the use of exosome vesicles for early diagnosis, follow-up, and the use of these physiological nanovectors as drug delivery systems for gastrointestinal cancer therapy.
Ynamines derived from nucleic acids bases: synthesis, reactivity and biological activity (1992)

Ynamines 1a–d are prepared by alkylation of nucleic acids bases with tetrachloroethylene followed by elimination of halogens from the intermediates 4a–d; reaction of 1a with acetone and cyclohexanone gives carbinols 8a and b and in the case of 8b cyclic ketal 9a is also obtained; compound 1a is a substrate for adenosine deaminase.
創意生活產業感性場域與感質商品之體驗－－The One 南園之個案研究 / Experiencing Kansei Space and Qualia Product in Creative Life Industries -- A Case Study of the One Nanyuan Land of Retreat and Wellness (2013)

創意生活產業指以創意整合生活產業的「核心知識」，提供「深度體驗」與「高 質美感」的產業。深度體驗包括服務與活動的創意;高質美感包括場域與產品的創意。面臨體驗經濟趨勢，創意生活產業如何運用「體驗 (experience)」，創造經濟效益及深耕文化價值，值得深入探討。本文以高質美感為主，進行 The One 南園個案研究，探討如何以體驗歷程，體驗策略，透過感性場域與感質產品，塑造及深植顧客的感動。研究結果發現：1. 以生活風格主張，展開體驗設計策略。2. 定調主軸性及次要性的體驗設計。3. 體驗歷程線索之設計，思考消費體驗訴求的重要線索與體驗方法。4. 設計高峰點體驗，加深顧客融入情境。5. 發展服務系統管理，界定關鍵服務設計與無接縫服務管理。後續研究，建議可將研究結果，綜整提出之體驗設計策略作法、歷程線索、體驗訴求等體驗發展架構，轉化為調查顧客體驗後分 析的參考要素。  Creative Life Industry, which integrate experiences of liveihood industries and local culture, plays an important role in guiding enterprises to apply the concepts of the economy. The deeply experience and highly aesthetic feeling are two important dimensions for designing customer for the Creative life industry. The one's Land of retreat and wellness was taken as an example to verify the highly aesthetic feeling model. This study found the followings: (1) Using the entrepreneur's lifestyle, applying to design strategy. (2) Using primary and secondary strategy for design. (3) Developing experiential goal, experiential clues and methods. (4) Designing the peaks of experiences, immersing visitors in activities. (5) Designing the key service processes and seamless service management.
Advanced epithelial ingrowth 6 months after laser in situ keratomileusis (2004)

Epithelial ingrowth is a common complication of laser in situ keratomileusis (LASIK). The cause is thought to be postoperative invasion of surface epithelial cells under the flap. We present a case of advanced epithelial cystic ingrowth that caused a profound reduction in visual acuity 6 months after a second LASIK enhancement.
Synthesis of Symmetrical Ureas by (Diacetoxyiodo)benzene-Induced Hofmann Rearrangement (2010)

Amides undergo Hofmann rearrangement by treatment with (diacetoxyiodo)benzene (DAIB) to provide symmetrical ureas in a simple and robust transformation.
A Positive Correlation between Bacterial Autoaggregation and Biofilm Formation in Native Sinorhizobium meliloti Isolates from Argentina (2012)

Sinorhizobium meliloti is a symbiotic nitrogen-fixing bacterium that elicits nodule formation on roots of alfalfa plants. S. meliloti produces two exopolysaccharides (EPSs), termed EPS I and EPS II, that are both able to promote symbiosis. EPS I and EPS II are secreted in two major fractions that reflect differing degrees of subunit polymerization, designated high- and low-molecular-weight fractions. We reported previously that EPSs are crucial for autoaggregation and biofilm formation in S. meliloti reference strains and isogenic mutants. However, the previous observations were obtained by use of "domesticated" laboratory strains, with mutations resulting from successive passages under unnatural conditions, as has been documented for reference strain Rm1021. In the present study, we analyzed the autoaggregation and biofilm formation abilities of native S. meliloti strains isolated from root nodules of alfalfa plants grown in four regions of Argentina. 16S rRNA gene analysis of all the native isolates revealed a high degree of identity with reference S. meliloti strains. PCR analysis of the expR gene of all the isolates showed that, as in the case of reference strain Rm8530, this gene is not interrupted by an insertion sequence (IS) element. A positive correlation was found between autoaggregation and biofilm formation abilities in these rhizobia, indicating that both processes depend on the same physical adhesive forces. Extracellular complementation experiments using mutants of the native strains showed that autoaggregation was dependent on EPS II production. Our results indicate that a functional EPS II synthetic pathway and its proper regulation are essential for cell-cell interactions and surface attachment of S. meliloti.
Touring Ant Colony Optimization Algorithm for Shaped-Beam Pattern Synthesis of Linear Antenna (2006)

An efficient search technique based on a touring ant colony optimization algorithm is presented for the shaped-beam pattern synthesis of a linear antenna array. The element excitations of equally spaced array and the element positions of uniformly excited array are determined to closely approximate the desired pattern. In the touring ant colony optimization algorithm, the frequency memory feature of tabu search is used. Illustrative examples of cosecant, flat-topped and pencil beam patterns are given to verify the validity and accuracy of the technique.
<i>Hwabyung</i> as Caregiving Stress Among Korean-American Caregivers of a Relative with Dementia (2003)

Abstract Qualitative research using narrative analysis was undertaken to illuminate how Korean-American caregivers with a relative with dementia give meaning to their caregiving experiences. Hwabyung as caregiving stress was described in the context of Korean culture. Two Korean born caregivers living in the United States, one indicating she had hwabyung and the other that she did not, participated in telephone interviews. Four themes emerged: (1) perception of dementia, (2) caregiving situation, (3) the expression of stress and (4) coping skills. The outcomes suggested that caregiving stress, and service needs for Korean Americans are similar to other groups, but the expression of stress is different. Alternative interventions for caregivers are then suggested.
Beamforming using spatial matched filtering with annular arrays (2007)

A linear array beamforming method for ultrasonic B-mode imaging using spatial matched filtering (SMF) and a rectangular aperture geometry was recently proposed Kim et al., [J. Acoust. Soc. Am. 120, 852-861 (2006)]. This letter extends those results to include circularly symmetric apertures. SMF applied to annular arrays can improve the lateral resolution and echo signal-to-noise ratio as compared with conventional dynamic-receive delay-sum beamforming. At high frequencies, where delay and sum beamforming is problematic, SMF showed greatly improved target contrast over an extended field of view.
Reconciling NMR Measurements and Numerical Simulations: Assessment of Temperature and Diffusive Coupling Effects on Two-Phase Carbonate Samples (2003)

Nuclear Magnetic Resonance (NMR) is the only logging technique sensitive to pore-size distribution and pore structure. However, quantitative interpretation of NMR data can become uncertain in carbonate rocks because of unaccounted diffusion coupling between existing pore scales. The objective of this study is to assess the relative importance of diffusion coupling and temperature on NMR measurements performed on a few carbonate samples. The core of our work is based on the analysis of experimental NMR measurements and on the use of numerical simulations. The numerical simulation algorithm consists of Monte-Carlo random walks in three dimensions and accounts for two-phase fluid saturations in the presence of a bimodal pore-size distribution. NMR coupling effects are modeled by including simple cross-interactions between the fluids within the different types of pores. We present a method based on rock image analysis to calibrate the numerical model to NMR laboratory measurements acquired in complex carbonate rocks at two stages of fluid saturation. The derived simulation models are subsequently used to generate equivalent decoupled responses of the samples. Comparison of these decoupled responses with experimental data allows one to assess the effect of diffusion coupling. The experimental data were also used to quantify the temperature dependence of NMR measurements and movable fluid volumes, normally determined assuming either a constant a priori formation T 2cutoff , or else parameters derived at ambient temperature. Finally, an analysis is made of the sensitivity of conventional permeability models to the combined effects of temperature and diffusion coupling, as evidenced by the core samples considered in this paper.
Integrative Analysis Revealing Human Adipose-Specific Genes and Consolidating Obesity Loci (2019)

Identification of adipose-specific genes has contributed to an understanding of mechanisms underlying adipocyte development and obesity. Herein, our analyses of the recent Genotype-Tissue Expression (GTEx) database revealed 38 adipose-specific/enhanced protein coding genes, among which 3 genes were novel adipose-specific, and 414 highly differentially expressed genes (DEGs) between subcutaneous and omental adipose depots. By integrative analyses of genome-wide association studies (GWASs), 14 adipose-specific/enhanced genes and 60 DEGs were found to be associated with obesity-related traits and diseases, consolidating evidence for contribution of these genes to the regional fat distribution and obesity phenotypes. In addition, expression of HOXC cluster was up-regulated in subcutaneous adipose tissue, and the majority of the HOXB cluster was expressed highly in omental adipose tissue, indicating differential expression patterns of HOX clusters in adipose depots. Our findings on the distinct gene expression profiles in adipose tissue and their relation to obesity provide an important foundation for future functional biological studies and therapeutic targets in obesity and associated diseases.
Deposition of Super‐Hydrophobic and Oleophobic Fluorocarbon Films in Radio Frequency Glow Discharges (2007)

Abstract Fluorocarbon films using a monomer, 1H, 1H, 2H‐perfluoro–1‐dodecene were deposited in a continuous radio frequency (RF) glow discharge, the process was carried out in a parallel‐plate RF discharge onto stainless steel reactor in order to produce coating with a water‐and oil–repellent surface. Fourier‐Transform Infrared spectroscopy (FT‐IR) and X‐ray Photoelectron Spectroscopy (XPS) revealed that the films obtained contain mainly perfluoromethylene (CF 2 ) species. Film wettability was tested using water and hydrocarbon liquids for contact angle measurements, furthermore surface energy was also calculated. Oil‐repellency was found to increase as the amount of CF 2 species increases in the film structure. Film morphology was studied by Atomic Force Microscopy (AFM), films showing an usual morphology from that typical of Plasma Polymerised Fluorocarbon (PPFC) films. The combination of the low surface energy coating and the surface morphology produces materials which are both water and oil repellency.
Dyssynchronous Pacing Triggers Endothelial-Mesenchymal Transition Through Heterogeneity of Mechanical Stretch in a Canine Model (2014)

RVP-induced DHF could aggravate fibrosis due to regional heterogeneity of mechanical stress, and it was better in the BiVP group where mechanical stress-induced EndMT might play a pivotal role through the integrin β1 pathway.
Stereoselective hetero-Diels-Alder reactions: structure determination of new xanthenedione derivatives by NMR spectroscopy and x-ray crystallography (1999)

The proton and carbon spectra of chromane derivatives were completely assigned by the use of 1H, 13C and 2D NMR spectroscopy, including NOESY and 2D INADEQUATE. The unambiguous configurational assignments of all regioisomers were achieved via 2D NOESY. The structure of the regioisomer 7A was confirmed using x-ray diffraction. © 1999 John Wiley & Sons, Ltd.
SciNet: Lessons Learned from Building a Power-efficient Top-20 System and Data Centre (2010)

SciNet, one of seven regional HPC consortia operating under the Compute Canada umbrella, runs Canada's first and third fastest computers (as of June 2010) in a state-of-the-art, highly energy-efficient datacentre with a Power Usage Effectiveness (PUE) design-point of 1.16. Power efficiency, computational "bang for the buck" and system capability for a handful of flagship science projects were important criteria in choosing the nature of the computers and the data centre itself. Here we outline some of the lessons learned in putting together the systems and the data centre that hosts Canada's fastest computer to date.