gebhart/patrepeval huggingface dataset:
Buffer Layer Assisted Laser Patterning of Metals on Surfaces (2004)

A new method is presented for a single pulse laser patterning of metallic thin films. This process is used to form submicron, variable width metallic wires. By employing laser desorption of a physisorbed buffer gas, a grating of gold has been patterned on a Ru(100) substrate under UHV conditions. Upon annealing, the physisorbed layer desorbs and the patterned metallic clusters softly land and strongly attach to the substrate. This versatile technique can be employed with practically any metallic element or molecular species.
A Total Organic Aqueous Redox Flow Battery Employing a Low Cost and Sustainable Methyl Viologen Anolyte and 4‐HO‐TEMPO Catholyte (2015)

Increasing worldwide energy demands and rising CO 2 emissions have motivated a search for new technologies to take advantage of renewables such as solar and wind energies. Redox flow batteries (RFBs) with their high power density, high energy efficiency, scalability (up to MW and MWh), and safety features are one suitable option for integrating such energy sources and overcoming their intermittency. However, resource limitation and high system costs of current RFB technologies impede wide implementation. Here, a total organic aqueous redox flow battery (OARFB) is reported, using low‐cost and sustainable methyl viologen (MV, anolyte) and 4‐hydroxy‐2,2,6,6‐tetramethylpiperidin‐1‐oxyl (4‐HO‐TEMPO, catholyte), and benign NaCl supporting electrolyte. The electrochemical properties of the organic redox active materials are studied using cyclic voltammetry and rotating disk electrode voltammetry. The MV/4‐HO‐TEMPO ARFB has an exceptionally high cell voltage, 1.25 V. Prototypes of the organic ARFB can be operated at high current densities ranging from 20 to 100 mA cm 2 , and deliver stable capacity for 100 cycles with nearly 100% Coulombic efficiency. The MV/4‐HO‐TEMPO ARFB displays attractive technical merits and thus represents a major advance in ARFBs.
360‐degree visual detection and target tracking on an autonomous surface vehicle (2010)

Abstract This paper describes perception and planning systems of an autonomous sea surface vehicle (ASV) whose goal is to detect and track other vessels at medium to long ranges and execute responses to determine whether the vessel is adversarial. The Jet Propulsion Laboratory (JPL) has developed a tightly integrated system called CARACaS (Control Architecture for Robotic Agent Command and Sensing) that blends the sensing, planning, and behavior autonomy necessary for such missions. Two patrol scenarios are addressed here: one in which the ASV patrols a large harbor region and checks for vessels near a fixed asset on each pass and one in which the ASV circles a fixed asset and intercepts approaching vessels. This paper focuses on the ASV's central perception and situation awareness system, dubbed Surface Autonomous Visual Analysis and Tracking (SAVAnT), which receives images from an omnidirectional camera head, identifies objects of interest in these images, and probabilistically tracks the objects' presence over time, even as they may exist outside of the vehicle's sensor range. The integrated CARACaS/SAVAnT system has been implemented on U.S. Navy experimental ASVs and tested in on‐water field demonstrations. © 2010 Wiley Periodicals, Inc.
Accurate and highly resolving quadri-wave lateral shearing interferometer, from visible to IR (2005)

A powerful and achromatic interferometric technique based on recent advances in the technology of non-diffracting arrays is used to evaluate wave-front distortions with a high transverse resolution and an easily tunable dynamic range. The device presented here belongs to the family of Multiple Wave Lateral Shearing Interferometers (MWLSI) and has the natural capability to measure simultaneously four wave-front derivatives. In this communication, we propose to exploit all the information de facto included in the interferogram; in this perspective we suggest a new method of reconstruction of the wave-front knowing its derivatives. We will show that our device is already successful in the field of laser metrology in the near infrared domain and that it is promising for the far infrared domain with the presentation of a prototype dedicated to measurements at 10.6µm.
Bubble rectifiers and reverse rotation transfer gates based on gaps in ion implanted propagation patterns (1981)

Gaps between unimplanted disks in ion implanted propagation patterns (I2P2’s) can allow bubbles to pass through in one direction and not in the opposite direction. These ’’bubble rectifiers’’ have been shown to perform a merge function. In a major-minor I2P2 bubble memory, a horizontal major line with a gap for each minor loop has been designed. Bubbles transferred out of minor loops down to this major line pass through the gaps and then propagate on the lower side past all the gaps to a detector, preserving the order of data tranferred in at the upper ends of the minor loops. For propagation on these multi-gapped lines, good bias field margins, somewhat lower than those for minor loop propagation, have been achieved with 2 μm gaps in 8 μm patterns and 1 μm gaps in 4 μm patterns. Using appropriately oriented gaps, bubbles can be transferred from one propagation track to another by temporary reversal of the drive field rotation direction. A family of reverse rotation transfer gates has been designed which provide selective transfer in or out of either end of the minor loops, depending on the starting phase and the number of reverse rotations, without disrupting adjacent data. The major advantage of these transfer gates is the absence of conductors.
The measurement of elastic waves in a nonferromagnetic plate by a patch-type magnetostrictive sensor (2004)

The coupling phenomenon between stress and magnetic induction, known as magnetostriction, has been successfully applied to generate and measure elastic waves. Most applications of this phenomenon thus far, however, are rather limited to cylindrical ferromagnetic waveguides. The main objective of this work is to develop a new patch-type, orientation-adjustable magnetostrictive transducer that is applicable for non-cylindrical, non-ferromagnetic waveguides. The existing patch-type transducer consisting of a ferromagnetic patch and a racetrack coil is useful to generate elastic waves only in one specific direction once the patch is bonded to a test specimen. However, the proposed transducer can transmit and receive elastic waves in any direction only with one patch at a given location. The proposed magnetostrictive transducer consists of a circular nickel patch, a figure-of-eight coil, and a couple of bias permanent magnets. Because of the unique configuration of the transducer, the propagating direction of the generated waves can be freely controlled since the set of bias magnets and the coil is not bonded to the magnetostrictive patch. In this work, the characteristics of the proposed transducer were investigated experimentally
Effect of Intracavernous Administration of Angiopoietin-4 on Erectile Function in the Streptozotocin-Induced Diabetic Mouse (2013)

Cavernous endothelial regeneration by use of Ang-4 protein may have potential for the treatment of vascular disease-induced ED, such as diabetic ED.
Weighted Reservoir Sampling from Distributed Streams (2019)

We consider message-efficient continuous random sampling from a distributed stream, where the probability of inclusion of an item in the sample is proportional to a weight associated with the item. The unweighted version, where all weights are equal, is well studied, and admits tight upper and lower bounds on message complexity. For weighted sampling with replacement, there is a simple reduction to unweighted sampling with replacement. However, in many applications the stream may have only a few heavy items which may dominate a random sample when chosen with replacement. Weighted samplingwithout replacement (weighted SWOR) eludes this issue, since such heavy items can be sampled at most once. In this work, we present the first message-optimal algorithm for weighted SWOR from a distributed stream. Our algorithm also has optimal space and time complexity. As an application of our algorithm for weighted SWOR, we derive the first distributed streaming algorithms for trackingheavy hitters with residual error. Here the goal is to identify stream items that contribute significantly to the residual stream, once the heaviest items are removed. Residual heavy hitters generalize the notion of $\ell_1$ heavy hitters and are important in streams that have a skewed distribution of weights. In addition to the upper bound, we also provide a lower bound on the message complexity that is nearly tight up to a $łog(1/\eps)$ factor. Finally, we use our weighted sampling algorithm to improve the message complexity of distributed $L_1$ tracking, also known as count tracking, which is a widely studied problem in distributed streaming. We also derive a tight message lower bound, which closes the message complexity of this fundamental problem.
An Iconoclastic View of Bacillus thuringiensis Ecology (1994)

Bacillus thuringiensis Berliner is a Gram-positive bacterium that upon sporulation produces a protein crystal toxic to certain pest insects. Strains of B. thuringiensis that affect the larvae of insects in Lepidoptera, Diptera, Coleoptera, and other orders have been identified. However, in general, much of the research that has been conducted using B. thuringiensis is not definitive.
Prospects of Spin Gyroscopes Based on Nitrogen-Vacancy Centers in Diamond (2018)

We are developing a solid-state gyroscope based on ensembles of nitrogen-vacancy centers in diamond. Rotation of the nitrogen-vacancy symmetry axis will induce Berry phase shifts in the electronic ground state 14N hyperfine sublevels and can be measured with a Ramsey technique.
A Cytotoxic Human Monoclonal Antibody Recognizing Cell Surface WT1 Peptide/HLA-A2 Complexes (2011)

Abstract Abstract 1677 The Wilms' tumor oncogene protein (WT1) is an attractive target for immunotherapy for a wide range of leukemias and cancers. WT1 is an intracellular transcription factor that is widely expressed in acute and chronic leukemias, but not appreciably in normal adult tissues. WT1 has been implicated in oncogenesis and appears to be expressed in the CML stem cell. Thus far, the intracellular location of WT1 has limited its use as a cancer target to T cell-based vaccine therapies. Several such vaccines directed to WT1 peptides are in clinical trials worldwide. However, such approaches is likely to be weaker and slower acting than typical antibody therapies that act directly to kill cells, especially for a leukemia that is not in remission. The WT1 peptide (RMFPNAPYL) is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ leukemia cells. Therefore, we hypothesized that a monoclonal antibody (mAb) specific for WT1 peptide/HLA-A2 complexes on the cell surface (a “TCR-like antibody”) could be an effective direct therapeutic agent alone, or armed with potent anti-cancer agents. In addition, such an antibody would provide a potential tool for identifying appropriate patients for clinical trials of both WT1 vaccine and WT1 mAb therapies, or as a prognostic tool. Using phage-display technology, we selected a number of human scFv phage mAbs specific for WT1 peptide RMFPNAPYL, when bound in the context of HLA-A0201 molecules. Bivalent, full-length human IgG1 mAbs were next constructed and tested for biochemical and immunological functions. The scFv phage mAbs bound specifically to T2 cells (TAP deficient) pulsed with WT1 peptide RMFPNAPYL, but not other HLA-A0201-binding peptides, demonstrating specific recognition of the WT1peptide/HLA-A0201 complex. Flow cytometry and radio-immunoassay was used to quantify sites, determine avidity, and show specificity. The IgG1 mAb showed high binding affinity (Kd= 0.2 nM) for the WT1 peptide/A0201 complex on live cells. The IgG1 mAb also recognized leukemia and tumor cell lines (n= 8 of 12) that expressed WT1, in an HLA-A0201, WT1 peptide-restricted manner, but not WT1-negative or HLA-A02-negative cells (n=13). The mAb was capable of killing WT1 peptide-pulsed T2 cells, as well as un-pulsed WT1+, A0201 + cancer cell lines, demonstrating presentation of the epitope in sufficient numbers for therapeutic attack. Complement mediated killing of cells was not seen. Alanine scanning of the epitope pointed to peptide position #1 as critical. In conclusion, cytotoxic human monoclonal antibodies targeting WT1 peptide/HLA complexes represent a novel therapeutic approach to target leukemias and solid tumors that over-express the intracellular WT1 oncoprotein. Disclosures: Yan: eureka therapeutics: Employment. Zhou:eureka therapeutics: Employment. Liu:eureka therapeutics: Employment.
Bis-naphthalimides: a new class of antitumor agents. (1993)

A series of bis-intercalators bearing the 1,8-naphthalimide chromophore has been synthesized and in vitro activities determined. Most compounds have higher activities in HT-29 than the leader compounds Mitonafide and Amonafide. One of them (22) was selected for in vivo studies and presents an interesting activity in MX-1 and OVCAR models. (22) also acts as antitopoisomerase II.
Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells (2015)

Duchenne muscular dystrophy (DMD) is a progressive and fatal muscle degenerating disease caused by a dystrophin deficiency. Effective suppression of the primary pathology observed in DMD is critical for treatment. Patient-derived human induced pluripotent stem cells (hiPSCs) are a promising tool for drug discovery. Here, we report an in vitro evaluation system for a DMD therapy using hiPSCs that recapitulate the primary pathology and can be used for DMD drug screening. Skeletal myotubes generated from hiPSCs are intact, which allows them to be used to model the initial pathology of DMD in vitro. Induced control and DMD myotubes were morphologically and physiologically comparable. However, electric stimulation of these myotubes for in vitro contraction caused pronounced calcium ion (Ca(2+)) influx only in DMD myocytes. Restoration of dystrophin by the exon-skipping technique suppressed this Ca(2+) overflow and reduced the secretion of creatine kinase (CK) in DMD myotubes. These results suggest that the early pathogenesis of DMD can be effectively modelled in skeletal myotubes induced from patient-derived iPSCs, thereby enabling the development and evaluation of novel drugs.
Crystal quartz optical whispering-gallery resonators (2008)

A quality factor exceeding 5x10(9) is obtained in whispering-gallery mode (WGM) resonators fabricated of crystalline quartz. We observe significant electrical tunability of WGMs in x-cut resonators and demonstrate an electro-optic modulator with a submegahertz passband at 12 GHz. We discuss other photonics applications of the crystal quartz WGM resonators in narrowband agile tunable filters, compact narrow linewidth lasers, and microwave and millimeter wave oscillators.
Advanced High‐Voltage Aqueous Lithium‐Ion Battery Enabled by “Water‐in‐Bisalt” Electrolyte (2016)

Abstract A new super‐concentrated aqueous electrolyte is proposed by introducing a second lithium salt. The resultant ultra‐high concentration of 28 m led to more effective formation of a protective interphase on the anode along with further suppression of water activities at both anode and cathode surfaces. The improved electrochemical stability allows the use of TiO 2 as the anode material, and a 2.5 V aqueous Li‐ion cell based on LiMn 2 O 4 and carbon‐coated TiO 2 delivered the unprecedented energy density of 100 Wh kg −1 for rechargeable aqueous Li‐ion cells, along with excellent cycling stability and high coulombic efficiency. It has been demonstrated that the introduction of a second salts into the “water‐in‐salt” electrolyte further pushed the energy densities of aqueous Li‐ion cells closer to those of the state‐of‐the‐art Li‐ion batteries.
New reduced-reference objective stereo image quality assessment model based on human visual system (2014)

With rapid development in three dimensional video technologies, quality assessment plays an important role in the field of stereo image processing. In this paper, a new reduced-reference stereo image quality assessment model based on binocular human visual system is proposed. The stereos images are divided into binocular fusion portion and binocular rivalry portion with the guide of internal generative mechanism. Then the binocular fusion portion is fused to cyclopean view. By extracting reduced singular value decomposition feature of cyclopean view and reduced generalized Gaussian distribution feature in binocular rivalry portion, the quality indicators of binocular fusion portion and binocular rivalry portion can be obtained. Experimental result shows that the proposed model outperforms some other models, and its correlation coefficients of assessment versus the subjective perception are satisfactory over five types of distortion, including JPEG, JPEG2000, Gaussian blur, white Gaussian noise and Fast-fading.
Circuit emulation services over Ethernet—Part 1: Clock synchronization using timestamps (2004)

Abstract Due to Ethernet's ubiquity, simplicity, scalability and cost effectiveness there is significant customer demand for Ethernet‐based access and transport in the metropolitan network. Many service providers have recognized this need and are currently establishing Ethernet‐based services to meet this demand. The migration to all‐Ethernet access will not be instantaneous since many customers currently have legacy TDM access interfaces on their routers and PBX equipment. Circuit Emulation Services (CES) over Ethernet provides TDM circuit emulation to support TDM traffic such as T1/E1, T3/E3, OC3/12, etc. This two‐part paper presents the application of CES over Ethernet as well as a new technology that addresses the issues associated with clock recovery and synchronization in an Ethernet network with its inherent network jitter. Part 1 describes a clock synchronization technique where a transmitter periodically sends explicit time indications or timestamps to a receiver to enable the receiver to synchronize its local clock to the transmitter's clock. Copyright © 2004 John Wiley & Sons, Ltd.
Extensible Data Skipping (2020)

Data skipping reduces I/O for SQL queries by skipping over irrelevant data objects (files) based on their metadata. We extend this notion by allowing developers to define their own data s kipping metadata types and indexes using a flexible A PI. Our framework i s t he first to natively support data skipping for arbitrary data types (e.g. geospatial, logs) and queries with User Defined Functions ( UDFs). We integrated our framework with Apache Spark and it is now deployed across multiple products/services at IBM. We present our extensible data skipping APIs, discuss index design, and implement various metadata indexes, requiring only around 30 lines of additional code per index. In particular we implement data skipping for a third party library with geospatial UDFs and demonstrate speedups of two orders of magnitude. Our centralized metadata approach provides a x3.6 speed up even when compared to queries which are rewritten to exploit Parquet min/max metadata. We demonstrate that extensible data skipping is applicable to broad class of applications, where user defined indexes achieve significant speedups and cost savings with very low development cost.
Discovery of Molecular Markers to Discriminate Corneal Endothelial Cells in the Human Body (2015)

The corneal endothelium is a monolayer of hexagonal corneal endothelial cells (CECs) on the inner surface of the cornea. CECs are critical in maintaining corneal transparency through their barrier and pump functions. CECs in vivo have a limited capacity in proliferation, and loss of a significant number of CECs results in corneal edema called bullous keratopathy which can lead to severe visual loss. Corneal transplantation is the most effective method to treat corneal endothelial dysfunction, where it suffers from donor shortage. Therefore, regeneration of CECs from other cell types attracts increasing interests, and specific markers of CECs are crucial to identify actual CECs. However, the currently used markers are far from satisfactory because of their non-specific expression in other cell types. Here, we explored molecular markers to discriminate CECs from other cell types in the human body by integrating the published RNA-seq data of CECs and the FANTOM5 atlas representing diverse range of cell types based on expression patterns. We identified five genes, CLRN1, MRGPRX3, HTR1D, GRIP1 and ZP4 as novel markers of CECs, and the specificities of these genes were successfully confirmed by independent experiments at both the RNA and protein levels. Notably none of them have been documented in the context of CEC function. These markers could be useful for the purification of actual CECs, and also available for the evaluation of the products derived from other cell types. Our results demonstrate an effective approach to identify molecular markers for CECs and open the door for the regeneration of CECs in vitro.
Antizyme induction by polyamine analogues as a factor of cell growth inhibition (2002)

The polyamines spermidine and spermine and their diamine precursor putrescine are essential for mammalian cell growth and viability, and strategies are sought for reducing polyamine levels in order to inhibit cancer growth. Several structural analogues of the polyamines have been found to decrease natural polyamine levels and inhibit cell growth, probably by stimulating normal feedback mechanisms. In the present study, a large selection of spermine analogues has been tested for their effectiveness in inducing the production of antizyme, a key protein in feedback inhibition of putrescine synthesis and cellular polyamine uptake. Bisethylnorspermine, bisethylhomospermine, 1,19-bis-(ethylamino)-5,10,15-triazanonadecane, longer oligoamine constructs and many conformationally constrained analogues of these compounds were found to stimulate antizyme synthesis to different levels in rat liver HTC cells, with some producing far more antizyme than the natural polyamine spermine. Uptake of the tested compounds was found to be dependent on, and limited by, the polyamine transport system, for which all these have approximately equal affinity. These analogues differed in their ability to inhibit HTC cell growth during 3 days of exposure, and this ability correlated with their antizyme-inducing potential. This is the first direct evidence that antizyme is induced by several polyamine analogues. Selection of analogues with this potential may be an effective strategy for maximizing polyamine deprivation and growth inhibition.
Newcastle Disease Virus-like Particles as a Platform for the Development of Vaccines for Human and Agricultural Pathogens (2010)

Vaccination is the single most effective way to control viral diseases. However, many currently used vaccines have safety concerns, efficacy issues or production problems. For other viral pathogens, classic approaches to vaccine development have, thus far, been unsuccessful. Virus-like particles (VLPs) are increasingly being considered as vaccine candidates because they offer significant advantages over many currently used vaccines or developing vaccine technologies. VLPs formed with structural proteins of Newcastle disease virus, an avian paramyxovirus, are a potential vaccine candidate for Newcastle disease in poultry. More importantly, these VLPs are a novel, uniquely versatile VLP platform for the rapid construction of effective vaccine candidates for many human pathogens, including genetically complex viruses and viruses for which no vaccines currently exist.