gebhart/patrepeval huggingface dataset:
Amino acid sequence analysis of a mouse interleukin 5 receptor protein reveals homology with a mouse interleukin 3 receptor protein (1991)

Abstract A polypeptide chain for the mouse interleukin 5 receptor (IL5R) was purified from detergent‐lysed B13 cells, a mouse IL5‐dependent pre‐B cell line. Purification was by a single immunoaffinity chromatographic step using an anti‐mouse IL 5R monoclonal antibody, R52. Internal amino acid sequence was obtained from four trypsin‐generated peptides. All peptides were found to be present in the published amino acid sequence of a mouse IL 3R and the mouse IL 3R‐like protein deduced from the cDNA. This indicates that the mouse IL 5R and the mouse IL 3R have a homologous polypeptide in common and suggests that the specificity of these lymphokine receptors is mainly generated by association with another ligand‐specific polypeptide chain.
Discontinuous seam-carving for video retargeting (2010)

We introduce a new algorithm for video retargeting that uses discontinuous seam-carving in both space and time for resizing videos. Our algorithm relies on a novel appearance-based temporal coherence formulation that allows for frame-by-frame processing and results in temporally discontinuous seams, as opposed to geometrically smooth and continuous seams. This formulation optimizes the difference in appearance of the resultant retargeted frame to the optimal temporally coherent one, and allows for carving around fast moving salient regions. Additionally, we generalize the idea of appearance-based coherence to the spatial domain by introducing piece-wise spatial seams. Our spatial coherence measure minimizes the change in gradients during retargeting, which preserves spatial detail better than minimization of color difference alone. We also show that per-frame saliency (gradient-based or feature-based) does not always produce desirable retargeting results and propose a novel automatically computed measure of spatio-temporal saliency. As needed, a user may also augment the saliency by interactive region-brushing. Our retargeting algorithm processes the video sequentially, making it conducive for streaming applications.
Coaxial cable Bragg grating (2011)

This paper reports a coaxial cable Bragg grating (CCBG) fabricated by drilling holes into the cable at periodic distances along the axial direction. Resonances were observed at discrete frequencies in both transmission and reflection spectra. The analogy of the CCBG with a fiber Bragg grating is shown. The grating was tested for the potential application as a strain-sensing device.
Synthetic substrates of vertebrate collagenase (1985)

The active site specificity of vertebrate collagenase was mapped with the synthesis of a variety of peptides, peptolides, and peptide esters. The enzyme was found to prefer very lipophilic sequences, and it was also found to be an esterase. The thio peptolide Ac-Pro-Leu-Gly-SCH[CH2CH(CH3)2]CO-Leu-Gly-OC2H5 was found to be an exceptional substrate. High-performance liquid chromatography and tandem mass spectrometry were used to unambiguously establish the cleavage site in several peptide substrates.
Vapourized-Metal Cluster Ion Source for Ion Plating (1974)

As particles to be ionized, a use of metal aggregates consisting of 102–103 atoms is proposed instead of atomic or molecular state particles in the ordinary type of ion source. As a result, a simple structural ion source for ion plating with a high deposition rate has been developed and fine quality deposition films are obtained on the surface of metal, semiconductor, or insulating substrate with strong adhesion. This ion source may be named "Vapourized-Metal Cluster Ion Source". In this paper, some typical characteristics of this type of ion source and properties of deposited film will be reported.
Improving Cloaking Detection using Search Query Popularity and Monetizability. (2006)

Cloaking is a search engine spamming technique used by some Web sites to deliver one page to a search engine for indexing while serving an entirely different page to users browsing the site. In this paper, we show that the degree of cloaking among search results depends on query properties such as popularity and monetizability. We propose estimating query popularity and monetizability by analyzing search engine query logs and online advertising click-through logs, respectively. We also present a new measure for detecting cloaked URLs that uses a normalized term frequency ratio between multiple downloaded copies of Web pages. Experiments are conducted using 10,000 search queries and 3 million associated search result URLs. Experimental results indicate that while only 73.1% of the cloaked popular search URLs are spam, over 98.5% of the cloaked monetizable search URLs are spam. Further, on average, the search results for top 2% most cloaked queries are 10x more likely to be cloaking than those for the bottom 98% of the queries.
Functionally graded titanium implants: Characteristic enhancement induced by combined severe plastic deformation (2019)

Commercially pure titanium was processed by equal channel angular pressing (ECAP) and surface mechanical attrition treatment (SMAT) for the purpose of developing functionally graded titanium used for implants and a gradient structure including nanostructured, deformed and undeformed zones were produced on the samples. In particular, it was aimed to design the gradient-structure in the titanium with enhanced properties by applying 4 ECAP passes to form bulk structure of ultrafine-grains and subsequently subjecting SMAT to the surface of ECAPed samples to produce nanostructured surface region. Microstructural examination was made by electron back scatter diffraction (EBSD). Also, microhardness, nanoindentation, topography, roughness and wettability were evaluated. To examine the biological response, human osteosarcoma cells were cultured in contact with the samples in various time periods and morphology change, cell viability and alkaline phosphate activity were conducted also cell morphology was monitored. EBSD showed development of ultrafine-grained structure after 4 passes of ECAP with an average grain size of 500 nm. Applying SMAT resulted in additional refinement in the ECAP samples, particularly in the subsurface regions to a depth of 112 μm. Furthermore, the SMATed samples showed an enhancement in roughness, wettability and hardness magnitudes. Viability enhanced up to 7% in SMATed + ECAPed sample, although the acceptable cell adhesion, improved cell differentiation and mineralization were seen. The combined use of ECAP and SMAT has shown a good potential for optimizing the design of modern functionally graded medical devices and implants.
Scalable non-square blind source separation in the presence of noise (2004)

Few source separation and independent component analysis approaches attempt to deal with noisy data. We consider an additive noise mixing model with an arbitrary number of sensors and possibly more sources than sensors (the "degenerate separation problem") when sources are disjointly orthogonal. We show how disjoint orthogonality can be viewed as a limit of a stochastic voice modeling assumption. This is the basis for our approach to noisy model estimation by maximum likelihood, under the direct-path far-field assumptions. The implementation of the derived criterion involves iterating two steps: a partitioning of the time-frequency plane for separation followed by an optimization of the mixing parameter estimates. The solution is applicable to an arbitrary number of microphones and sources. Experimentally, we show the capability of the technique to separate four voices from two, four, six and eight channel recordings in the presence of strong noise.
Optimization of the Excitation Light Sheet in Selective Plane Illumination Microscopy (2015)

Selective plane illumination microscopy (SPIM) is a powerful technique used for 3D live fluorescence imaging in biological research Unlike conventional fluorescence imaging techniques based on the epi-illumination configuration, SPIM uses two objectives with optical axis orthogonal to each other for sample excitation and fluorescence detection separately. By confining the excitation light near the detection focal plane, SPIM allows high speed 3D imaging with high 3D spatial resolution, good optical sectioning capability, and minimal photobleaching and phototoxicity.
6‐Heteroaryl‐pyrazolo[3,4‐b]pyridines: Potent and Selective Inhibitors of Glycogen Synthase Kinase‐3 (GSK‐3). (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Estimation of<i>In vivo</i>Cancellous Bone Elasticity (2009)

The effect of decreasing bone density (a symptom of osteoporosis) is greater for cancellous bone than for dense cortical bone, because cancellous bone is metabolically more active. Therefore, the bone density or bone mineral density of cancellous bone is generally used to estimate the onset of osteoporosis. Elasticity or elastic constant is a fundamental mechanical parameter and is directly related to the mechanical strength of bone. Accordingly, elasticity is a preferable parameter for assessing fracture risk. A novel ultrasonic bone densitometer LD-100 has been developed to determine the mass density and elasticity of cancellous bone with a spatial resolution comparable to that of peripheral quantitative computed tomography. Bone density and bone elasticity are evaluated using ultrasonic parameters based on fast and slow waves in cancellous bone by modeling the ultrasonic wave propagation path. Elasticity is deduced from the measured bone density and the propagation speed of the fast wave. Thus, the elasticity of cancellous bone is approximately expressed by a cubic equation of bone density.
Concentration independent modulation of local micromechanics in a fibrin clot (2011)

Optical tweezers active microrheology (AMR) probes microdomain mechanical properties in 3D engineered tissues. The application of a nonuniform strain field setups up distributed stiffness, measured by AMR, which yields differential cell phenotypes.
Origami and 4D printing of elastomer-derived ceramic structures (2018)

Four-dimensional (4D) printing involves conventional 3D printing followed by a shape-morphing step. It enables more complex shapes to be created than is possible with conventional 3D printing. However, 3D-printed ceramic precursors are usually difficult to be deformed, hindering the development of 4D printing for ceramics. To overcome this limitation, we developed elastomeric poly(dimethylsiloxane) matrix nanocomposites (NCs) that can be printed, deformed, and then transformed into silicon oxycarbide matrix NCs, making the growth of complex ceramic origami and 4D-printed ceramic structures possible. In addition, the printed ceramic precursors are soft and can be stretched beyond three times their initial length. Hierarchical elastomer-derived ceramics (EDCs) could be achieved with programmable architectures spanning three orders of magnitude, from 200 μm to 10 cm. A compressive strength of 547 MPa is achieved on the microlattice at 1.6 g cm<sup>-3</sup>. This work starts a new chapter of printing high-resolution complex and mechanically robust ceramics, and this origami and 4D printing of ceramics is cost-efficient in terms of time due to geometrical flexibility of precursors. With the versatile shape-morphing capability of elastomers, this work on origami and 4D printing of EDCs could lead to structural applications of autonomous morphing structures, aerospace propulsion components, space exploration, electronic devices, and high-temperature microelectromechanical systems.
Blue-Noise Sigma-Delta Modulator: Improving Substrate Noise and Nonlinear Amplifier Gain Effects (2007)

This paper presents a method to reduce the effects of substrate noise and nonlinear amplifier gain on sigma-delta (ΣΔ) modulators through the use of blue-noise modulation. In addition to reducing the effects of substrate noise and nonlinear amplifier gain, the proposed architecture also suppresses the effects of integrator opamp non-idealities, such as 1/f noise and DC offset, and DAC DC offset and even-order nonlinearities. The architecture proposed herein is referred to as the blue-noise ΣΔ modulator. An example utilizing a third-order blue-noise ΣΔ modulator with a 1-bit quantizer is presented. Additionally, a method to generate the required blue-noise modulation sequence is proposed. Simulation results demonstrate that this architecture achieves an 8.8dB improvement in SNDR over the traditional third-order ΣΔ modulator.
Film-Forming Properties of Estolides (2005)

Estolides are biobased materials obtained from synthesis of ingredients derived from agricultural products. They are oligoesters obtained by the reaction of fatty acids and/or methyl esters with a double bond. By varying the chemistries of the starting materials and the reaction conditions, estolides of varying chemical structures, and physical properties are obtained. Estolides have been found to have suitable properties for some lubrication applications. However, the effect of estolide chemical/physical characterstics on its tribological properties have yet to be understood. In this work, the effect of estolide physical/chemical variability on its film-forming properties is examined.
Novel platform for minimizing cell loss on separation process: Droplet-based magnetically activated cell separator (2007)

To reduce the problem of cell loss due to adhesion, one of the basic phenomena in microchannel, we proposed the droplet-based magnetically activated cell separator (DMACS). Based on the platform of the DMACS-which consists of permanent magnets, a coverslip with a circle-shaped boundary, and an injection tube-we could collect magnetically (CD45)-labeled (positive) cells with high purity and minimize cell loss due to adhesion. To compare separation efficiency between the MACS and the DMACS, the total number of cells before and after separation with both the separators was counted by flow cytometry. We could find that the number (3241/59 940) of cells lost in the DMACS is much less than that (22 360/59 940) in the MACS while the efficiency of cell separation in the DMACS (96.07%) is almost the same as that in the MACS (96.72%). Practically, with fluorescent images, it was visually confirmed that the statistical data are reliable. From the viability test by using Hoechst 33 342, it was also demonstrated that there was no cell damage on a gas-liquid interface. Conclusively, DMACS will be a powerful tool to separate rare cells and applicable as a separator, key component of lab-on-a-chip.
Antibody fragments for controlled delivery of therapeutic agents (1995)

Conference Article| November 01 1995 Antibody fragments for controlled delivery of therapeutic agents M. E. Verhoeyen; M. E. Verhoeyen 1Unilever Research, Colworth Laboratories, Sharnbrook, MK44 1LQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar C. P. E. van der Logt; C. P. E. van der Logt 1Unilever Research, Colworth Laboratories, Sharnbrook, MK44 1LQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar T. S. Beggs; T. S. Beggs 1Unilever Research, Colworth Laboratories, Sharnbrook, MK44 1LQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar P. J. Davis P. J. Davis 1Unilever Research, Colworth Laboratories, Sharnbrook, MK44 1LQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1995) 23 (4): 1067–1073. https://doi.org/10.1042/bst0231067 Article history Received: June 15 1995 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation M. E. Verhoeyen, C. P. E. van der Logt, T. S. Beggs, P. J. Davis; Antibody fragments for controlled delivery of therapeutic agents. Biochem Soc Trans 1 November 1995; 23 (4): 1067–1073. doi: https://doi.org/10.1042/bst0231067 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.
Precise determination of the optimal coil for wireless power transfer systems through postprocessing in the smooth boundary representation (2016)

This paper proposes a novel coil layout optimization that can determine the optimal coil design under the given working condition for wireless power transfer systems, using the smooth boundary representation. The optimized coil layout is validated through the experiments under the same condition.
Adaptive sparse reconstruction for lensless digital holography via PSF estimation and phase retrieval (2022)

In-line lensless digital holography has great potential in multiple applications; however, reconstructing high-quality images from a single recorded hologram is challenging due to the loss of phase information. Typical reconstruction methods are based on solving a regularized inverse problem and work well under suitable image priors, but they are extremely sensitive to mismatches between the forward model and the actual imaging system. This paper aims to improve the robustness of such algorithms by introducing the adaptive sparse reconstruction method, ASR, which learns a properly constrained point spread function (PSF) directly from data, as opposed to solely relying on physics-based approximations of it. ASR jointly performs holographic reconstruction, PSF estimation, and phase retrieval in an unsupervised way by maximizing the sparsity of the reconstructed images. Like traditional methods, ASR uses the image formation model along with a sparsity prior, which, unlike recent deep learning approaches, allows for unsupervised reconstruction with as little as one sample. Experimental results in synthetic and real data show the advantages of ASR over traditional reconstruction methods, especially in cases where the theoretical PSF does not match that of the actual system.
Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification (2020)

A series of vancomycin C-terminus guanidine modifications is disclosed that improves antimicrobial activity, enhances the durability of antimicrobial action against selection or induction of resistance, and introduces a synergistic mechanism of action independent of d-Ala-d-Ala binding and inhibition of cell wall biosynthesis. The added mechanism of action results in induced bacterial cell permeability, which we show may involve interaction with cell envelope teichoic acid. Significantly, the compounds examined that contain two combined peripheral modifications, a (4-chlorobiphenyl)methyl (CBP) and C-terminus guanidinium modification, offer opportunities for new treatments against not only vancomycin-sensitive but especially vancomycin-resistant bacteria where they act by two synergistic and now durable mechanisms of action independent of d-Ala-d-Ala/d-Lac binding and display superb antimicrobial potencies (MIC 0.6-0.15 μg/mL, VanA VRE). For the first time, we demonstrate that the synergistic behavior of the peripheral modifications examined requires the presence of both the CBP and guanidine modifications in a single molecule versus their combined use as an equimolar mixture of singly modified compounds. Finally, we show that a prototypical member of the series, G3-CBP-vancomycin (<b>15</b>), exhibits no hemolytic activity, displays no mammalian cell growth inhibition, possesses improved and especially attractive <i>in vivo</i> pharmacokinetic (PK) properties, and displays excellent <i>in vivo</i> efficacy and potency against an especially challenging multidrug-resistant (MRSA) and VanA vancomycin-resistant (VRSA) <i>Staphylococcus aureus</i> bacterial strain.
Nucleotide sequence of the Dpn II DNA methylase gene of Streptococcus pneumoniae and its relationship to the dam gene of Escherichia coli. (1985)

The structural gene (dpnM) for the Dpn II DNA methylase of Streptococcus pneumoniae, which is part of the Dpn II restriction system and methylates adenine in the sequence 5'-G-A-T-C-3', was identified by subcloning fragments of a chromosomal segment from a Dpn II-producing strain in an S. pneumoniae host/vector cloning system and demonstrating function of the gene also in Bacillus subtilis. Determination of the nucleotide sequence of the gene and adjacent DNA indicates that it encodes a polypeptide of 32,903 daltons. A putative promoter for transcription of the gene lies within a hundred nucleotides of the polypeptide start codon. Comparison of the coding sequence to that of the dam gene of Escherichia coli, which encodes a similar methylase, revealed 30% of the amino acid residues in the two enzymes to be identical. This homology presumably reflects a common origin of the two genes prior to the divergence of Gram-positive and Gram-negative bacteria. It is suggested that the restriction function of the gene is primitive, and that the homologous restriction system in E. coli has evolved to play an accessory role in heteroduplex DNA base mismatch repair.
The distributed Josephson inductance phase shifter (1992)

The authors report on a novel microwave phase shifter featuring rapid electronic adjustment, continuous phase control true time delay operation, high device fault tolerance, and very broadband operation. By coupling a large number of superconducting quantum interference devices (SQUIDs) to a superconducting microstrip transmission line, a variable magnetic medium in which the wave velocity is controlled electronically is created. The authors have measured 60 degrees phase shift at 10 GHz, and wideband operation from 5 to 15 GHz for an 8-cm-long Nb transmission line coupled to 1600 SQUIDs, each containing a single Nb/AlO/sub x//Nb tunnel junction. The observed phase shift corresponds to a change in wave velocity of about 1 part in 60.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Utilization of Iron Additives for Advanced Control of NO<i><sub>x</sub></i> Emissions from Stationary Combustion Sources (2001)

A novel NOx control technique based on the utilization of iron-containing compounds was studied. Iron-containing additives can be injected in small amounts either into the combustion zone or, if reburning is used, into the reburning zone to reduce NOx emissions. Tests in a 300-kW Boiler Simulator Facility demonstrate that iron additives achieve 20−30% NOx reduction without reburning, whereas in conjunction with reburning, they increase NOx reduction from about 60%, typical for conventional reburning, to about 80−85%. The additives tested included powdered metallic iron, iron oxides, iron waste, Fe(CO)5, char, and ash. Up to 1000 ppm (atomic Fe basis) was added to the flue gas. Experimental variables studied include additive composition and amount, injector location, and reburning heat input. Depending on the additive, the effect is dominated by either heterogeneous or homogeneous reactions.
Self-Sufficient and Exclusive Oxygenation of Methane and Its Source Materials with Oxygen to Methanol via Metgas Using Oxidative Bi-reforming (2013)

A combination of complete methane combustion with oxygen of the air coupled with bi-reforming leads to the production of metgas (H2/CO in 2:1 mole ratio) for exclusive methanol synthesis. The newly developed oxidative bi-reforming allows direct oxygenation of methane to methanol in an overall economic and energetically efficient process, leaving very little, if any, carbon footprint or byproducts.