gebhart/patrepeval huggingface dataset:
Acidic drug transport in vivo through the blood-brain barrier. A role of the transport carrier for monocarboxylic acids. (1990)

The relationship of the transports between acidic drugs and monocarboxylic acids through the blood-brain barrier (BBB) was examined using the carotid artery injection technique in rats. The BBB uptakes of [3H]acetic acid and [14C]salicylic acid were significantly reduced by the presence of the respective unlabeled compounds, valproic acid, lactic acid, benzoic acid, nicotinic acid or beta-lactam antibiotics (benzylpenicillin, propicillin and cefazolin), but was not reduced by choline, phenylalanine and a basic drug, eperisone. A remarkable pH dependency was observed for the BBB uptake of [14C]salicylic acid at the pH region of 4.0 to 7.4. Interestingly, 10 mM of salicylic acid diminished significantly the pH dependent BBB uptake of [14C]salicylic acid. Similar results were obtained in the BBB uptake of [14C]nicotinic acid. No significant difference was observed in the transport of monocarboxylic acids through the BBB between normotensive Wistar KY rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). From these observations, acidic drugs could be transported by a carrier-mediated system for monocarboxylic acids at the BBB and the transport system was not changed by the disease state.
[Study on fingerprint of rhizoma chuanxiong by HPLC-DAD-MS]. (2004)

The established HPLC fingerprint is very specific, and can be used to evaluate the quality consistency of different rhizoma Chuanxiong herbs.
Application of BIM and 3D Laser Scanning for Quantity Management in Construction Projects (2020)

The construction industry has played an essential role in the process of modernization and industrialization and it has also been a major factor in determining the development of the infrastructure for other economic sectors. Construction companies consider the measurement of work progress, which often wastes time and has a low resolution, to be one of the most challenging problems faced by project management. Therefore, this research aimed to propose practical solutions by applying recent technological achievements of the 4.0 industrial revolution to improve the efficiency of the quantity management process. By utilizing the advantages and features of a BIM model and 3D laser scanning, this paper proposes that adopting a BIM model and 3D laser scanning has the potential to improve the accuracy and efficiency of the quantity management process. The case study demonstrated some typical tasks to evaluate accuracy and efficiency as well as to showcase the research proposal.
[Regulatory effect of curcumin on renal apoptosis and its mechanism in overtraining rats]. (2018)

The 8-week incremental load swimming training triggered excessive training in rats, aggravated oxidative stress and accelerated renal apoptosis, leading to pathological changes and dysfunction of kidney. Curcumin can up-regulate expression of Nrf2 and HO-1, effectively alleviates oxidative stress induced by overtraining, thereby increasing Bcl-2 expression, decreasing Bax expression, inhibiting renal apoptosis and protecting renal tissue structure and function properly.
Facilitating engineering analysis via a graphical database (2002)

The advent of Microsoft Windows and other graphical user interface (GUI) platforms has ushered in a host of "visual" applications that greatly simplify the task of data entry, as compared to conventional methods. This paper describes a unique Windows GUI application that enables an engineer to draw a one-line diagram, interactively enter bus and device parameters into dialog box fields, and then save this date to a power systems database. This innovative method of "visually" entering date into a power systems database is significant addition to the one-line drawing capabilities of this application. In addition, the application makes extensive use of Windows features which enhance the robustness of the software from both the developer's end user's viewpoint.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lipopolysaccharide antagonists block taxol-induced signaling in murine macrophages. (1993)

Taxol is the prototype of a new class of microtubule stabilizing agents with promising anticancer activity. Several studies show that taxol mimics the actions of lipopolysaccharide (LPS) on murine macrophages. To investigate the mechanism of taxol-induced macrophage stimulation, we evaluated the ability of Rhodobacter sphaeroides diphosphoryl lipid A (RsDPLA) and SDZ 880.431 to block taxol-induced effects. RsDPLA and SDZ 880.431 are lipid A analogues that lack LPS-like activity, but inhibit the actions of LPS, presumably by blocking critical cellular binding sites. We report that RsDPLA and SDZ 880.431 potently inhibited taxol-induced TNF secretion, gene activation, and protein-tyrosine phosphorylation. The role of microtubules in taxol signaling was investigated. Taxol-induced microtubule bundling in primary and transformed RAW 264.7 macrophages was not blocked by RsDPLA or SDZ 880.431. Taxotere, a semisynthetic taxoid, was more potent than taxol as an inducer of microtubule bundling, but did not induce tumor necrosis factor alpha secretion and gene activation. These data dissociate the microtubule effects of taxol from macrophage stimulation and suggest that taxol stimulates macrophages through an LPS receptor-dependent mechanism. The results underscore the potential of taxol as a tool for studying LPS receptor activation and provide insights into possible therapeutic actions of this new class of drugs.
Ocular Infection and Immunity (1996)

Part 1 Introduction and historical perspectives: ocular immunology ocular microbiology immunodeficiencies immune-mediated ocular. Part 2 Diseases: anterior disorders posterior disorders orbital disorders disorders involving multiple structures. Part 3 Infectious ocular diseases: anterior disorders posterior disorders orbital disorders.
Embedded memory fail analysis for production yield enhancement (2011)

The traditional approach for memory fail bitmap analysis is to identify the topological signatures and perform a Failure Analysis investigation on the most frequent signatures, based on the (x, y) coordinates of the fails. This approach is inappropriate when a large portion of the fails are single bits, because too many investigations are required to statistically identify the major repetitive failure mechanisms. This becomes a problem for fast product development and production yield ramp. This paper presents a methodology to classify single fail bits by their unique fault signature, based on the sequence of failing march element read operations from multiple data backgrounds, in a standard Memory BIST flow. These classifications allow investigations to focus on the most important failure mechanisms with greatest yield impact. The methodology is demonstrated in an industrial environment, with identification of critical yield detractors. Starting from a yield problem associated to MBIST failures at high operating temperature, the fault signatures were used to identify a static noise margin parametric problem and a dislocation fault physical problem.
A framework for managing QoS and improving performance of dynamic Web content (2002)

The proportion of dynamic objects has been growing at a fast rate in the World Wide Web. However, because of additional resource requirements and the changing nature of these objects, the performance of accessing dynamic Web content has been observed to be poor in the current generation Web services. We propose a framework called WebGraph that helps in improving the response time for accessing dynamic objects. The WebGraph framework manages a graph for each of the Web pages. Both the nodes and the edges have attributes that are used in managing the Web pages. Instead of recomputing and recreating the entire page, the node and edge attributes are used to update a subset of the Weblets are then integrated to form the entire page. In addition to the performance benefits in terms of lower response time, the WebGraph framework facilitates Web caching, QoS support, load balancing, overload control, personalized services, and security for both dynamic as well as static Web pages.
Magnesium supplements may enhance the effect of antihypertensive medications in stage 1 hypertensive subjects (2010)

Mg supplements above RDA may be necessary to significantly lower high blood pressure in Stage I HT unless subjects have been continuously treated with anti-HT medications >/= 6 months. Such medication use may lower by half the oral Mg dose needed to significantly decrease high blood pressure. Oral Mg therapy may have no effect in studies with normotensive subjects. Study of oral Mg therapy for severe or complicated hypertension has been neglected. Often the first cardiovascular risk factor to present, high blood pressure may be an early opportunity to correct poor Mg status and its possible complications including cardiovascular disease, respiratory diseases, and type 2 diabetes. Such preventive potential encourages quantification of these findings and testing of these hypotheses with a meta-analysis using categories elucidated by this preliminary study and finally would warrant a call for a prospective study.
Motion Retrieval Using Low‐Rank Subspace Decomposition of Motion Volume (2011)

Abstract This paper proposes a novel framework that allows for a flexible and an efficient retrieval of motion capture data in huge databases. The method first converts an action sequence into a novel representation, i.e. the Self‐Similarity Matrix (SSM), which is based on the notion of self‐similarity. This conversion of the motion sequences into compact and low‐rank subspace representations greatly reduces the spatiotemporal dimensionality of the sequences. The SSMs are then used to construct order‐3 tensors, and we propose a low‐rank decomposition scheme that allows for converting the motion sequence volumes into compact lower dimensional representations, without losing the nonlinear dynamics of the motion manifold. Thus, unlike existing linear dimensionality reduction methods that distort the motion manifold and lose very critical and discriminative components, the proposed method performs well even when inter‐class differences are small or intra‐class differences are large. In addition, the method allows for an efficient retrieval and does not require the time‐alignment of the motion sequences. We evaluate the performance of our retrieval framework on the CMU mocap dataset under two experimental settings, both demonstrating promising retrieval rates.
Measured performance of the IEEE 802.11 wireless LAN (2003)

The practical network performances of two commercial IEEE 802.11 compliant wireless local area networks (WLANs) are measured at the medium access control sublayer. A number of tests conducted on the WLANs yielded important characteristics such as throughput and response time under various network loads. The results reveal that the buffering and fragmentation of data frames can seriously influence the performance of an IEEE 802.11 WLAN. Although the length of a data frame and the bit rate of the wireless transceiver also affect the WLANs transmission capabilities, its performance is generally unaffected by the type of frame addressing and the use of reservation frames such as request-to-send (RTS) and clear-to-send (CTS). These observations have not been reported in the analytical, simulation or measurement studies carried out so far. Thus, the detailed empirical results presented in this paper will be useful for administrators of IEEE 802.11 WLAN systems.
Automatic video background replacement using shape-based probabilistic spatio-temporal object segmentation (2007)

While video background replacement has an extensive range of applications, the chroma-keying process is still the most widely applied despite it having to maintain specific lighting conditions, a blue (or green) background, and the requirement of painstaking manual handling. This paper addresses these issues by presenting a novel fully automatic video background replacement technique that does not require any specific recording constraints. This paper employs a generic shape-based probabilistic spatio-temporal (PST) video object segmentation algorithm employing a Gaussian mixture model (GMM) to achieve a long-desired outcome towards fully automated video background replacement techniques. Experimental results using a number of standard video test sequences reveal the merits of the proposed technique.
Fluorescence lifetime in cardiovascular diagnostics (2010)

We review fluorescence lifetime techniques including time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.
High‐Efficiency Hybrid Solar Cells Based on Polymer/PbS<sub>x</sub>Se<sub>1‐x</sub> Nanocrystals Benefiting from Vertical Phase Segregation (2013)

Solution-processed hybrid solar cells employing a low band-gap polymer and PbSx Se1-x alloy nanocrystals, achieving a record high PCE of 5.50% and an optimal FF of 67% are presented. The remarkable device efficiency can be attributed to the high-performance active materials, the optimal polymer/NCs ratio and, more importantly, the vertical donor/(donor:acceptor)/acceptor structure which benefits charge dissociation and transport.
Automated lip synchronisation for human-computer interaction and special effect animation (1997)

The research presents MARTI (Man-machine Animation Real-Time Interface) for the realisation of automated special effect animation and human computer interaction. MARTI introduces novel research in a number of engineering disciplines, which include speech recognition, facial modelling, and computer animation. This interdisciplinary research utilises the latest, hybrid connectionist/hidden Markov model system, providing very accurate phone recognition and timing for speaker independent continuous speech, and expands' knowledge from the animation industry in the development of accurate facial models and automated animation. The system uses simple vocal soundtracks of human speakers to provide lip synchronisation of computer graphical facial models, to realise the first natural interface and animation system capable of high performance for real users and real-world applications.
Diphtheria toxin: nucleotide binding and toxin heterogeneity. (1980)

We have used flow dialysis to demonstrate binding of ATP and related compounds to diphtheria toxin. The results define a new site on the toxin molecule (the P site), which has distinctly different properties from the NAD+-binding site of the fragment A moiety. The relative affinities of various compounds for the P site are similar to their capacities to inhibit toxin attachment to cell surfaces and its action on cells. This suggests that the P site may correspond to the binding site for cell surface receptors. Affinity of nucleotides for the toxin depends strongly on the number of phosphates, although both nucleoside and phosphate moieties contribute to the interaction. A substantial fraction of the toxin in any given preparation did not bind ATP in a rapidly reversible manner and was not retained on ATP-Sepharose. This fraction, which varied in magnitude from preparation to preparation, was isolated and shown to contain an endogenous, firmly bound nucleotide or nucleotide-like compound. The presence of this compound may explain some of the physical heterogeneity within individual preparations of purified toxin as well as variations in physical and biological properties among various preparations.
Iron-catalyzed synthesis of cinnarizine (2015)

Cinnarizine was synthesized in a high yield by iron-catalyzed cross-coupling of phenylmagnesium chloride with 1-[(2E)-3-chloroprop-2-en-1-yl]-4-(diphenylmethyl)piperazine prepared by allylation of 1-(diphenylmethyl) piperazine with (E)-1,3-dichloropropene.
Wrapper-based selection of genetic features in genome-wide association studies through fast matrix operations (2012)

Greedy RLS is the first known implementation of a machine learning based method with the capability to conduct a wrapper-based feature selection on an entire GWAS containing several thousand examples and over 400,000 variants. In our experiments, greedy RLS selected a highly predictive subset of genetic variants in a fraction of the time spent by wrapper-based selection methods used together with SVM classifiers. The proposed algorithms are freely available as part of the RLScore software library at http://users.utu.fi/aatapa/RLScore/.
Self-Evolving Subscriptions for Content-Based Publish/Subscribe Systems (2017)

Traditional pub/sub systems cannot adequately handle workloads of applications with dynamic, short-lived subscriptions such as location-based social networks, predictive stock trading, and online games. Subscribers must continuously interact with the pub/sub system to remove and insert subscriptions, thereby inefficiently consuming network and computing resources, and sacrificing consistency. In the aforementioned applications, we recognize that the changes in the subscriptions can follow a predictable pattern over some variable (e.g., time). In this paper, we present a new type of subscription, called evolving subscription, which encapsulates these patterns and allow the pub/sub system to autonomously adapt to the dynamic interests of the subscribers without incurring an expensive re-subscription overhead. We propose a general model for expressing evolving subscriptions and a framework for supporting them in a pub/sub system. To this end, we propose three different designs to support evolving subscriptions, which are evaluated and compared to the traditional resubscription approach in the context of two use cases: online games and high-frequency trading. Our evaluation shows that our solutions can reduce subscription traffic by 96.8% and improve delivery accuracy when compared to the baseline resubscription mechanism.
Video digests (2014)

Increasingly, authors are publishing long informational talks, lectures, and distance-learning videos online. However, it is difficult to browse and skim the content of such videos using current timeline-based video players. Video digests are a new format for informational videos that afford browsing and skimming by segmenting videos into a chapter/section structure and providing short text summaries and thumbnails for each section. Viewers can navigate by reading the summaries and clicking on sections to access the corresponding point in the video. We present a set of tools to help authors create such digests using transcript-based interactions. With our tools, authors can manually create a video digest from scratch, or they can automatically generate a digest by applying a combination of algorithmic and crowdsourcing techniques and then manually refine it as needed. Feedback from first-time users suggests that our transcript-based authoring tools and automated techniques greatly facilitate video digest creation. In an evaluative crowdsourced study we find that given a short viewing time, video digests support browsing and skimming better than timeline-based or transcript-based video players.
Identification of antisense long noncoding RNAs that function as SINEUPs in human cells (2016)

Mammalian genomes encode numerous natural antisense long noncoding RNAs (lncRNAs) that regulate gene expression. Recently, an antisense lncRNA to mouse Ubiquitin carboxyl-terminal hydrolase L1 (Uchl1) was reported to increase UCHL1 protein synthesis, representing a new functional class of lncRNAs, designated as SINEUPs, for SINE element-containing translation UP-regulators. Here, we show that an antisense lncRNA to the human protein phosphatase 1 regulatory subunit 12A (PPP1R12A), named as R12A-AS1, which overlaps with the 5' UTR and first coding exon of the PPP1R12A mRNA, functions as a SINEUP, increasing PPP1R12A protein translation in human cells. The SINEUP activity depends on the aforementioned sense-antisense interaction and a free right Alu monomer repeat element at the 3' end of R12A-AS1. In addition, we identify another human antisense lncRNA with SINEUP activity. Our results demonstrate for the first time that human natural antisense lncRNAs can up-regulate protein translation, suggesting that endogenous SINEUPs may be widespread and present in many mammalian species.
Selectivity and Potency of Agonists for the Three Subtypes of Cloned Human β-Adrenoceptors Expressed in Chinese Hamster Ovary Cells (2000)

The selectivities, potencies and efficacies of beta3-adrenoceptor (beta3-AR) agonists on human three beta-AR subtypes expressed in Chinese hamster ovary (CHO) cells were investigated using radioligand binding assay and cyclic AMP (cAMP) accumulation assay. The three beta-AR subtypes showed the nature of G protein-coupled receptors with the constitutive activity. BRL37344, CL-316,243 and a newly synthesized beta3-AR agonist N-5984, 6-[2-(R)-[[2-(R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid, were compared for the potency and selectivity for the beta3-AR. In the radioligand binding assay, the affinity of N-5984 for beta3-ARs was 14, 70 and 220 times more potent than those of BRL37344, isoproterenol and CL-316,243, respectively. N-5984 had higher selectivity than BRL37344 for human beta3-ARs compared with either for beta1-ARs or beta2-ARs. N-5984 showed higher potency and intrinsic activity of cAMP production than BRL37344 in CHO cells expressing the beta3-ARs. CL-316,243 had almost no activity of cAMP production in CHO cells expressing any subtype of beta-ARs. These results indicate that N-5984 is the most potent and selective agonist for human beta3-ARs than any other agonists tested.