gebhart/patrepeval huggingface dataset:
Collateral sensitivity to cross-linking agents exhibited by cultured L1210 cells resistant to oxazaphosphorines. (1985)

The sensitivity of cultured L1210 and P388 cells, sensitive (L1210/0, P388/0) and resistant (L1210/CPA, P388/CPA) to cyclophosphamide in vivo, to five oxazaphosphorine and eight nonoxazaphosphorine cross-linking agents was determined. Each of the resistant sublines was cross-resistant to all of the oxazaphosphorines tested. The P388/CPA cell line was also cross-resistant to all of the nonoxazaphosphorines but, in most cases, not nearly to the same extent. The L1210/CPA cell line was collaterally sensitive to all but one of the nonoxazaphosphorines, in which case it was equisensitive. Changes in sensitivity could not be accounted for by changes in intracellular pH values, or by changes in intracellular inorganic phosphate or acid-soluble organic phosphate concentrations. Inasmuch as the L1210/CPA cell line was specifically resistant to the oxazaphosphorines, identification of the phenotypic basis for this resistance should serve to identify a potentially important determinant with regard to the basis for the oncotoxic specificity of this group of agents.
Cobalt‐Catalyzed Alkyne Hydrosilylation and Sequential Vinylsilane Hydroboration with Markovnikov Selectivity (2016)

A pyridinebis(oxazoline) cobalt complex is a very efficient precatalyst for the hydrosilylation of terminal alkynes with Ph2 SiH2 , providing α-vinylsilanes with high (Markovnikov) regioselectivity and broad functional-group tolerance. The vinylsilane products can be further converted into geminal borosilanes through Markovnikov hydroboration with pinacolborane and a bis(imino)pyridine cobalt catalyst.
Cognitive therapy in bipolar disorder (2002)

Stress-vulnerability models are increasingly viewed as plausible explanations of recurrence in severe affective disorders. This has promoted greater interest in the application of evidence-based psychological treatments, such as cognitive therapy, as an adjunct to medication for patients with bipolar disorder. This paper reviews the results from outcome studies of combined treatment approaches. Preliminary findings indicate that cognitive therapy reduces symptoms, enhances social adjustment and functioning and reduces relapses and hospitalizations in patients with bipolar disorder. However, the lack of published data from large scale randomized controlled trials and the absence of an adequate psychological model of manic relapse means that the role of cognitive therapy in bipolar disorders will be the subject of intense debate for some time to come.
Telmisartan Inhibits Cell Proliferation by Blocking Nuclear Translocation of ProHB-EGF C-Terminal Fragment in Colon Cancer Cells (2013)

The inhibition of HB-EGF-CTF nuclear translocation with telmisartan may be a novel strategy in preventing cell proliferation.
Geospatial Ontology Development and Semantic Analytics (2006)

Geospatial ontology development and semantic knowledge discovery addresses the need for modeling, analyzing and visualizing multimodal information, and is unique in offering integrated analytics that encompasses spatial, temporal and thematic dimensions of information and knowledge. The comprehensive ability to provide integrated analysis from multiple forms of information and use of explicit knowledge make this approach unique. This also involves specification of spatiotemporal thematic ontologies and populating such ontologies with high quality knowledge. Such ontologies form the basis for defining the meaning of important relations terms, such as near or surrounded by, and enable computation of spatiotemporal thematic proximity measures we define. SWETO (Semantic Web Technology Evaluation Ontology) and geospatial extension SWETO-GS are examples of these ontologies. The Geospatial Semantics Analytics (GSA) framework incorporates: (1) the ability to automatically and semi-automatically tract metadata from syntactically (including unstructured, semi-structured and structured data) and semantically heterogeneous and multimodal data from diverse sources; and (2) analytical processing that exploits these ontologies and associated knowledge bases, with integral support for what we term spatiotemporal thematic proximity (STTP) reasoning and interactive visualization capabilities. This paper discusses the results of our geospatial ontology development efforts as well as some new semantic analytics methods on this ontology such as STTP.
Determinants of DNA Quadruplex Structural Type:  Sequence and Potassium Binding (1999)

There are DNA sequences which adopt the same quadruplex structural type in the presence of sodium as in the presence of sodium and potassium. There are also sequences that appear to have a requirement for the presence of potassium for the adoption of a particular quadruplex structural type. Information about the basis for these potassium effects has been obtained by examining the structures of a set of DNAs with differing numbers of loop residues and different lengths of runs of dG residues in the presence of sodium alone and in the presence of potassium and sodium. On the basis of the results, obtained primarily via solution-state NMR, it appears that very small loops favor parallel stranded quartet structures which do not require the presence of potassium. DNAs with loops of two to four residues and runs of two dG residues can form quadruplex structures of the "edge" or "chair" type in the presence of potassium but not in the presence of sodium alone. When all of the loops contain four residues, a "crossover" or "basket" type structure can be formed in the presence of sodium as well as in the presence of sodium and potassium. Structures with runs of three or four dG residues and with loops from two to four residues can form basket or crossover type structures in the absence of potassium. The presence of a purine in a loop can block both potassium binding and formation of chair type structures. Modeling of the interactions of cations with these quadruplex structures indicates that the potassium ions required for chair type structures interact with a terminal quartet and residues in the adjacent loop.
Local band bending and grain-to-grain interaction induced strain nonuniformity in polycrystalline CdTe films (2014)

The local physical properties of polycrystalline semiconducting films drive their performances in a wide variety of optoelectronic devices but are still not completely elucidated. These properties are investigated and correlated on the same region of polycrystalline CdTe films by combining electron backscattered diffraction, \ensuremath{\mu}-Laue x-ray experiments using synchrotron radiation, electron beam-induced current, and cathodoluminescence. The local band bending is revealed at random grain boundaries: its characteristics vary from one grain to another, depending on the nature of grain boundaries and the doping level in the nearby grains, in agreement with the theoretical approach of the double Schottky potential barriers. In contrast, no local band bending occurs at \ensuremath{\Sigma}3 growth twins since these extended defects have no dangling bonds in their center. Additionally, the density of unpaired dislocations and the components of the strain and stress tensors are found to be highly nonuniform from one grain to another and within the grains themselves. This reveals that grain-to-grain interactions (i.e., collective effects) occur during the Volmer-Weber-type growth. These findings emphasize the critical importance of grain boundary design engineering. They also highlight how polycrystalline semiconducting films work locally and show the complexity of the local physical processes governing their macroscopic performances in optoelectronic devices.
Cloud Imaging Using the NRL WARLOC Radar (2003)

The Naval Research Laboratory has recently developed a 3–10 kW average, 80 kW peak power 94 GHz radar with scanning capability, WARLOC. This radar is powered by a gyroklystron developed by a team led by NRL. One application has been to image clouds. New capabilities of WARLOC include imaging with greatly improved sensitivity and detail as well as the ability to detect much lower strength cloud returns. Here we show how pulse averaging enhances the sensitivity of WARLOC. Since the available power is so high, it can be used in moderate rain to both measure the rainfall rate and to image the cloud above the rain.
Nanoscale nonlinear optics in photonic-crystal fibres (2006)

Photonic-crystal fibres with submicrometre waveguiding channels enhance nonlinear-optical processes, leading to unique regimes of nanoscale nonlinear-optical interactions. Here we provide an overview of the basic physical mechanisms behind the remarkable nonlinear-optical performance of micro- and nanochannel waveguides and discuss physically different scenarios of nonlinear-optical spectral and temporal transformations of ultrashort pulses in silica and multicomponent-glass photonic-crystal fibres, as well as in natural submicrometre waveguides encountered in biological objects. Small-size waveguides in photonic-crystal fibres with carefully optimized dispersion are used for the frequency shifting and shaping of ultrashort laser pulses, offering much promise for the creation of novel compact and convenient light sources for nonlinear spectroscopy.
Car surveillance security system (2017)

Car automation and surveillance is an escalating trend in this decade. Smart Vehicle security is becoming an indispensable need as it makes it easier for the owners to ensure their automobile's safety wirelessly. The core elements in our system consists of a mini central processing unit, motion detecting sensor accompanied with a camera module and buzzer. Our security network can be used to monitor and control the car wirelessly. We are using Putty software which senses motion, triggers the buzzer, takes the picture and mails it to the owner. The common platform used here is the mini CPU `Raspberry Pi' which interfaces all the embedded peripherals simultaneously, so that our vehicle can be managed through our mobile phones with minimal cost. This paper highlights the advantages of internet of Things and shows how it can be used for realizing smart car security using Raspberry pi, camera module and sensors.
Mobilization of peripheral blood progenitor cells with paclitaxel-based chemotherapy. (1997)

An essential component of combination high-dose chemotherapy and irradiation for the treatment of a variety of solid and hematologic malignancies is the ability to collect and reinfuse large numbers of peripheral blood progenitor cells (PBPCs). The reinfused PBPCs are used to replace pluripotent hematopoietic stem cells after marrow ablative therapy and to potentiate earlier blood cell count recovery after myelosuppressive (but not truly ablative) treatment. The PBPCs are mobilized from the marrow compartment into the peripheral bloodstream after treatment with chemotherapy, granulocyte colony-stimulating factor, or both. A number of single and combination chemotherapeutic agents have been used to mobilize PBPCs. In administering these agents, a balance must be found in all cases between effective PBPC mobilization and possible damage to the hematopoietic stem cell pool and overall patient tolerance. Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) causes no thrombocytopenia or cumulative hematopoietic toxicity and was found to effectively mobilize PBPCs without damaging the stem cell pool. Paclitaxel has the additional advantage of not causing the bladder toxicity seen with cyclophosphamide. Its antitumor effectiveness in breast and ovarian cancer makes it an especially useful component of therapy for both pretreatment cytoreduction as well as PBPC mobilization in these patients.
loxP-Directed Cloning: Use of Cre Recombinase as a Universal Restriction Enzyme (2001)

We have developed a novel way to use the Cre/loxP system for in vitro manipulation of DNA and a technique to clone DNA into circular episomes. The method is fast, reliable, and allowsflexible cloning of DNA fragments into episomes containing a loxP site. We show that a loxP site can serve as a universal target site to clone a DNA fragment digested with any restriction enzyme(s). This technique abolishes the need for compatible restriction sites in cloning vectors and targets by generating custom-designed 5' 3', or blunt ends in the desired orientation and reading frame in the vector Therefore, this method eliminates the limitations encountered when DNA fragments are cloned into vectors with a confined number of cloning sites. The 34-bp loxP sequence assures uniqueness, even when large episomes are manipulated. We present three examples, including the manipulation of a bacterial artificial chromosome. Because DNA manipulation takes place at a loxP site, we refer to this technique as loxP-directed cloning.
Intracellular localization of factor VIII-related antigen and fibronectin in cultured human endothelial cells: evidence for divergent routes of intracellular translocation. (1984)

Cultured human endothelial cells synthesize and secrete both fibronectin and factor VIII-related antigen (VIIIR:Ag). In immunofluorescence microscopy, intracellular fibronectin was seen diffusely perinuclearly whereas VIIIR:Ag was located both diffusely in the perinuclear cytoplasm and in distinct rod-shaped granules. These granules could, moreover, be visualized with fluorochrome-coupled Ricinus communis agglutinin I (RCA), which also stained the Golgi apparatus as a reticular juxtanuclear structure, and they were identified as Weibel-Palade bodies by immunoelectron microscopy. Puromycin treatment depleted intracellular fibronectin but did not affect the granular localization of VIIIR:Ag. A short exposure of the cells to monensin caused a juxtanuclear accumulation of fibronectin at the Golgi region whereas VIIIR:Ag only was seen in rounded cytoplasmic granules. A prolonged monensin treatment brought about a cytoplasmic accumulation of fibronectin-containing vesicles whereas VIIIR:Ag showed no accumulation and there was no codistribution between granules containing fibronectin or VIIIR:Ag. Type IV procollagen, on the other hand, was distinctly co-localized with fibronectin. In monensin-treated cells RCA mainly stained the VIIIR:Ag-containing vesicles whereas Concanavalin A (Con A) appeared to label the fibronectin-containing vesicles. Immunoelectron microscopy of these cells revealed VIIIR:Ag in some vacuolar structures and typical Weibel-Palade bodies could not be identified. Exposure of the cells to tunicamycin, on the other hand, caused a prominent cytoplasmic accumulation of VIIIR:Ag and, within 96 h, led to the disappearance of most of the VIIIR:Ag-positive granules but did not affect the intracellular distribution of fibronectin. These results, which show that metabolical inhibitors affect differently the intracellular compartmentalization of fibronectin and VIIIR:Ag, indicate, that the two glycoproteins have divergent intracellular pathways in cultured human endothelial cells.
DiffTrace: Efficient Whole-Program Trace Analysis and Diffing for Debugging (2019)

We present a tool called DiffTrace that approaches debugging via whole program tracing and diffing of typical and erroneous traces. After collecting these traces, a user-configurable front-end filters out irrelevant function calls and then summarizes loops in the retained function calls based on state-of-the-art loop extraction algorithms. Information about these loops is inserted into concept lattices, which we use to compute salient dissimilarities to narrow down bugs. DiffTrace is a clean start that addresses debugging features missing in existing approaches. Our experiments on an MPI/OpenMP program called ILCS and initial measurements on LULESH, a DOE miniapp, demonstrate the advantages of the proposed debugging approach.
Illness as Behaviour (1975)

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Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms* (1997)

Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT activity is regulated by a common genetic polymorphism that is associated with large individual variations in thiopurine toxicity and efficacy. We previously cloned the functional gene for human TPMT and reported a common variant allele for low enzyme activity, TPMT*3A, that contains point mutations at cDNA nucleotides 460 and 719. In the present study, we set out to determine the number, types, and frequencies of TPMT variant alleles associated with low enzyme activity in clinical laboratory samples in the United States and to compare those results with data obtained from two different ethnic groups. We identified a total of six different variant alleles for low TPMT activity in the 283 clinical laboratory samples studied. The most common variant was *3A; the second most frequent variant allele, *3C, contained only the nucleotide 719 polymorphism; and four other variant alleles were detected. TPMT*3A also appeared to be the most common variant allele in a Norwegian white population sample, but it was not found in a population sample of Korean children. However, *3C was present in samples from the Korean children, as was a novel allele, *6. Characterization of variant alleles for low TPMT enzyme activity will help make it possible to assess the potential clinical utility of deoxyribonucleic acid-based diagnostic tests for determining TPMT genotype. Clinical Pharmacology & Therapeutics (1997) 62, 60–73; doi:
Identification and Characterization of MicroRNAs Expressed in the Mouse Eye (2007)

The data provide a detailed characterization of expression of eye-enriched miRNAs. Knowledge of the spatiotemporal distribution of miRNAs is an essential step toward the identification of their targets and eventually the elucidation of their biological role in eye development and function.
Local search for DAG scheduling and task assignment (2002)

Scheduling DAGs to multiprocessors is one of the key issues in high-performance computing. Local search can be used to effectively improve the quality of a scheduling algorithm. In this paper, based on topological ordering, we present a fast local search algorithm which can improve the quality of DAG scheduling algorithms. This low complexity algorithm can effectively reduce the length of a given schedule.
Bowel injury associated with liver surgery for hepatocellular carcinoma. (2006)

Previous hepatectomy increases the risk for bowel injury during hepatectomy. Care must be taken to prevent adhesion to the hepatic cut surface. Careful use of electrocautery to prevent burn injury also should be taken.
Flexible automation of a biotechnological pilot-plant with real-time network (1994)

The development of biochemical engineering towards integrated bioprocesses have influenced the demands of the applied control environment. In the pilot-plant of GBF we use a controller area network (CAN) based field-bus network to interconnect the decentralized process control computers under real-time conditions. In this paper the implementation and the performance of the CAN field-bus in an hierarchical automation concept is outlined. While some fermenters and downstream devices are connected to the network directly via an A/D converter and bus access in a so-called mini-module, other fermenters are automated with decentralized process computers which act as bus nodes with full functionality. A master computer interconnects several sub-nets and supervises the proper operating of all network components. In addition, a database is handled from this master, where all objects in the network, representing measured, controlled or online calculated variables, are specified. The CAN application layer enables an open communication from CAN-modules of different manufacturers. The CAN-message-specification allows the description of the data transfer between the individual user programs via a client/server model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nalbuphine Is Better Than Naloxone for Treatment of Side Effects After Epidural Morphine (1992)

This study compared naloxone and nalbuphine when administered for treatment of side effects after epidural morphine, 5 mg, given for postcesarean analgesia. Patients requesting treatment for pruritus or nausea randomly received, in a double-blind fashion, up to three intravenous doses of either naloxone 0.2 mg (group 1; n = 20) or nalbuphine 5 mg (group 2; n = 20). The incidence of vomiting, the severity of nausea and pruritus, and the degree of sedation and pain were assessed before and 30 min after each dose. The first dose of nalbuphine decreased the incidence of vomiting (P < 0.005) and the severity of nausea and pruritus (P < 0.01), whereas naloxone caused no significant changes. Sedation scores increased after nalbuphine (P < 0.05) and remained unchanged after naloxone, whereas pain scores increased after naloxone (P < 0.01) and were unchanged after nalbuphine. Eighteen patients in group 1 and 12 in group 2 received a second dose, and 8 and 4 patients, respectively, a third dose. Other than decreased pruritus after the second dose with both drugs, no further changes occurred. We conclude that nalbuphine is superior to naloxone for the treatment of side effects after epidural morphine. However, persistent symptoms may require supplemental therapy, as repeated doses proved less effective than the initial dose.
Study of Various Location Tracking Techniques for Centralized Location, Monitoring & Control System (2014)

Location tracking and control system require efficient resource management as well as reduction in their GSM network service cost. The data is transferred through GSM network by using SMS. This increases the system capability by efficiently managing tracking devices which could increase in number as time goes by (GPS) has become a common functionality in handheld devices, and therefore, several location-tracking applications have been developed like GPS, GPRS, IMEI number, etc.,. Some techniques consume more time, less efficiency and more error rates. Location prediction is performed by using the current location, moving speed, and bearing of the target to predict its next location. When the distance between the predicted location and the actual location exceeds a certain threshold, the target transmits a short message to the tracker to update its current location. This paper presents a various tracking Techniques for Centralized location, Monitoring & Control System.