gebhart/patrepeval huggingface dataset:
Biomechanical Modeling of Refractive Corneal Surgery (2005)

The aim of refractive corneal surgery is to modify the curvature of the cornea to improve its dioptric properties. With that goal, the surgeon has to define the appropriate values of the surgical parameters in order to get the best clinical results, i.e., laser and geometric parameters such as depth and location of the incision, for each specific patient. A biomechanical study before surgery is therefore very convenient to assess quantitatively the effect of each parameter on the optical outcome. A mechanical model of the human cornea is here proposed and implemented under a finite element context to simulate the effects of some usual surgical procedures, such as photorefractive keratectomy (PRK), and limbal relaxing incisions (LRI). This model considers a nonlinear anisotropic hyperelastic behavior of the cornea that strongly depends on the physiological collagen fibril distribution. We evaluate the effect of the incision variables on the change of curvature of the cornea to correct myopia and astigmatism. The obtained results provided reasonable and useful information in the procedures analyzed. We can conclude from those results that this model reasonably approximates the corneal response to increasing pressure. We also show that tonometry measures of the IOP underpredicts its actual value after PRK or LASIK surgery.
Velocity planning approach for autonomous vehicles (2016)

Motion planning being one of the core functionalities of autonomous driving system, has been studied and investigated with great interest by the developers across industries and academia.Collision avoidance is one of the major challenges within trajectory planning problem (TPP).This master thesis is inspired from the 'concept of decomposition of trajectory planning problem in to path planning and velocity planning' which results in great reduction in the computational complexity of the TPP.The work in this project is focused on the velocity planning with the known path so that the collision with the moving vehicles is avoided.Concept of space time scheduling is used along with the A* (A star) search algorithm in a particular fashion to achieve the time optimal speed profile.The approach developed in this work is deterministic but has possibility to work with probabilistic motion model of the vehicles in the traffic.It also has great potential to work with the different road geometries and different vehicle maneuvers such as merging, yielding, intersection, etc.Hence, it is very promising approach for velocity planning with possibilities to work with variety of scenarios.
Enzymic resolution of (.+-.)-unsaturated cyclic terpene alcohols via asymmetric hydrolysis of corresponding acetates by microorganisms. (1980)

Asymmetric hydrolysis of the acetates of(±)-cis and trans-carveols by microorganisms or their esterase produced chiral cis and trans-carveols and the acetates of their enantiomers. The enantioselectivity of the microbial hydrolysis and the optical purities of the products varied with the species of microorganisms. This method was also applied in separation of diastereomeric mixtures of (-)-carveols and (-)-7-epi-α-cyperols.
THE EFFECT OF MOISTURE ON FRICTION COEFFICIENT OF ELASTIC KNITTED FABRICS (2008)

Kumas yuzeyi ile deri arasindaki surtunme, giysilerin konfor performanslarini belirleyen onemli bir parametredir. Bu calismada farkli oranda elastan iceren orme kumaslarda nem iceriginin surtunme katsayisina etkisi arastirilmistir. Olcumler Minho Universitesinde gelistirilip patent alinmis, kumaslarin surtunme katsayisinin belirlenmesinde yeni bir metoda dayali olarak olcum yapan FRICTORQ cihazi ile yapilmistir. Kumasta artan nem miktari ile surtunme katsayisinin belirli bir limite kadar artmakta oldugu tespit edilmistir. Yaklasik % 40’in uzerindeki nem degerlerinde surtunme katsayisi sabit hale gelmektedir. Yari elastan iceren ve en sik yapidaki kumaslar en yuksek surtunme degerleri vermistir
Histopathology of the Inner Ear in Unoperated Acoustic Neuroma (2003)

Although hearing loss is the most common presenting symptom in patients with acoustic neuroma, the pathophysiology of hearing loss associated with acoustic neuroma is unknown. Although primary dysfunction of the auditory nerve is intuitively logical, available histopathologic and clinical data suggest that although neural degeneration is common, it alone does not adequately account for hearing loss in many cases. The purpose of this study was to evaluate 11 cases of unoperated unilateral acoustic neuromas. Temporal bones were identified by means of a search mechanism provided by the National Temporal Bone, Hearing, and Balance Pathology Resource Registry and were prepared for light microscopy by standard techniques. Quantification of spiral ganglion cells, hair cells, stria vascularis, and spiral ligament was accomplished for each specimen. In addition, the maximum diameter and volume of each tumor were calculated from histopathologic sections. Increasing tumor size did predict a reduced spiral ganglion count. However, although there was a tendency for decreasing spiral ganglion cell count and for increasing tumor size to predict a higher pure tone average and lower speech discrimination score, these correlations did not reach statistical significance. In tumor ears in which the speech discrimination score was 50% or less, there was always significant degeneration of other structures of the inner ear in addition to neurons, including hair cells, the stria vascularis, and the spiral ligament. Endolymphatic hydrops and eosinophilic precipitate in the perilymphatic spaces were found in 2 of 3 such cases. It is concluded that acoustic neuromas appear to cause hearing loss, not only by causing degeneration of the auditory nerve, but also by inducing degenerative changes in the inner ear. It is hypothesized that the proteinaceous material seen histologically may represent the products of up-regulated genes in acoustic neuroma, some of which may interfere with normal cochlear function.
Expression of the <i>Escherichia coli pcnB</i> gene is translationally limited using an inefficient start codon: a second chromosomal example of translation initiated at AUU (2002)

Expression of the gene pcnB, encoding the dispensable Escherichia coli poly(A) polymerase (PAPI), which is toxic when overproduced, was investigated. Its promoter was identified and found to be moderately strong when used to express a beta-galactosidase reporter. Expression levels were not affected by increasing or decreasing PcnB concentration. Translation of pcnB was found to initiate from the non-canonical initiation codon AUU. The only other coli gene reported to use AUU as initiation codon is infC, which encodes the initiation factor IF-3. AUU, in common with other rarely used initiation codons, is discriminated against by IF-3, resulting in the aborting of most AUU-promoted initiation events. This enables AUU to form part of an autoregulatory circuit controlling IF-3 production. We show that InfC discrimination reduces PcnB production fivefold. This is the first instance of this mechanism being used to limit severely the production of a potentially toxic product.
Guidance properties of low-contrast photonic bandgap fibres (2005)

We investigate the guidance properties of low-contrast photonic band gap fibres. As predicted by the antiresonant reflecting optical waveguide (ARROW) picture, band gaps were observed between wavelengths where modes of the high-index rods in the cladding are cutoff. At these wavelengths, leakage from the core by coupling to higher-order modes of the rods was observed directly. The low index contrast allowed for bend loss to be investigated; unlike in index-guiding fibres, anomalous "centripetal" light leakage through the inside of the bend can occur.
Induction of human myeloblastic ML-1 cell G1 arrest by suppression of K+ channel activity (1996)

Our previous studies have shown that a voltage-gated K+ channel is highly expressed in proliferating human myeloblastic ML-1 cells and is suppressed in the early stages of 12-O-tetradecanoylphorbol-13-acetate-induced ML-1 cell differentiation. In the present study, we report that inhibition of the K+ channel activity by 4-aminopyridine (4-AP) suppressed ML-1 cell proliferation, as measured by DNA synthesis. Cell cycle mapping indicated that ML-1 cells were arrested in G1 phase after 24-h treatment with 4-AP. Blockade of ML-1 cells at the G1/S boundary of the cell cycle with aphidicolin revealed that ML-1 cells past the G1 checkpoint were capable of entering S phase and synthesizing DNA independently of the channel blockade. ML-1 cell differentiation, measured by CD14 marker protein expression, revealed that the effect of 4-AP was to cause growth arrest and that it did not cause differentiation. Dephosphorylation of retinoblastoma protein accompanied inhibition of ML-1 cell proliferation and suggested that suppression of K+ channel activity by 4-AP is associated with retinoblastoma protein-mediated G1 arrest in ML-1 cells. Moreover, we found that ML-1 cell volume increased 35 +/- 7% after 4-AP treatment, which could be an early event triggering inhibition of ML-1 cell proliferation. These findings suggest that a 4-AP-sensitive K+ channel may play an important role in the transduction of mitogenic signals in ML-1 cells.
Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain (2020)

Activation of the T cell receptor (TCR) results in binding of the adapter protein Nck (noncatalytic region of tyrosine kinase) to the CD3ϵ subunit of the TCR. The interaction was suggested to be important for the amplification of TCR signals and is governed by a proline-rich sequence (PRS) in CD3ϵ that binds to the first Src homology 3 (SH3) domain of Nck (Nck-SH3.1). Inhibition of this protein/protein interaction ameliorated inflammatory symptoms in mouse models of multiple sclerosis, psoriasis, and asthma. A small molecule, AX-024, was reported to inhibit the Nck/CD3ϵ interaction by physically binding to the Nck1-SH3.1 domain, suggesting a route to develop an inhibitor of the Nck1/CD3ϵ interaction for modulating TCR activity in autoimmune and inflammatory diseases. We show here that AX-024 reduces T cell proliferation upon weak TCR stimulation but does not significantly affect phosphorylation of Zap70 (ζ chain of T cell receptor-associated protein kinase 70). We also find that AX-024 is likely not involved in modulating the Nck/TCR interaction but probably has other targets in T cells. An array of biophysical techniques did not detect a direct interaction between AX-024 and Nck-SH3.1 <i>in vitro</i> Crystal structures of the Nck-SH3.1 domain revealed its binding mode to the PRS in CD3ϵ. The SH3 domain tends to generate homodimers through a domain swap. Domain swaps observed previously in other SH3 domains indicate a general propensity of this protein fold to exchange structural elements. The swapped form of Nck-SH3.1 is unable to bind CD3ϵ, possibly representing an inactive form of Nck in cells.
Finite control set model predictive control with feedback correction for power converters (2018)

As an open-loop model predictive control algorithm, finite control set model predictive control (FCS-MPC) scheme in power converter system is based on assumption that responses of optimal control implemented on prediction model agree well with actual system. The influence of model parameter mismatches and environment disturbance on control performance of scheme is neglected. Then, based on feedback correction strategy in traditional model predictive control algorithm, we derive a finite control set model predictive control with feedback correction scheme (FCS-MPCFC) that allows us to adjust prediction model output at current instant by model prediction error at previous instant, and the closed-loop correction of prediction model output is achieved. Simulations comparison analyses on a two-level three-phase inverter with multi-type model parameter mismatches controlled by traditional and improved FCS-MPC scheme are presented. Experiments are carried out on DSP controller platform.
Stokes phase preservation during Raman amplification (1986)

Experiments have been performed to measure the degree to which the phase information on an input Stokes beam can be preserved in a hydrogen Raman amplifier in the presence of phase and intensity nonuniformities on the pump beam. The experiments were conducted at Fresnel numbers of about 40 and at amplified Stokes fluences of up to 3.4 J cm−2. Astigmatism and focus on the pump did not transfer to the Stokes, and astigmatism on the input Stokes was maintained during amplification. Strong, ordered intensity nonuniformities on the pump beam resulted in large wave-front errors on the amplified Stokes, possibly due to a self-focusing effect. A more uniform pump resulted in an amplified Stokes beam quality of 1.2 times the diffraction limit.
Integrating Transport Programmes for Sustainable Reduction in Urban Road Congestion—Best Practise Examples from Local Authorities Working with SUITS (2023)

This chapter highlights selected sustainable transport measures that were implemented in nine partner cities during the SUITS project and discusses outcomes and learnings. Mutual exchanges, either in workshops or focussed meetings between the cities, provided inspiration for planning and implementing sustainable transport measures. For the project team, such exchanges provided insights into challenges the cities faced on a day-to-day basis which were used to develop training material and further understand the organisational process. During the project, cities worked on transport measures in five broad topic areas: clean fuels and low emission vehicles, collective passenger transport, vulnerable road users, safety and security and intelligent transport systems and services. Here, we present a selection to illustrate the scope of the undertaking and, how the project was able to enhance the implementation of each initiative.
Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With <i>EGFR</i> Mutations (2023)

Afatinib is associated with prolongation of PFS when compared with standard doublet chemotherapy in patients with advanced lung adenocarcinoma and <i>EGFR</i> mutations.
Current understanding of neuroprotection in glaucoma (2002)

The most common optic neuropathy is glaucomatous optic neuropathy, distinguished by a distinctive and progressive excavation of the optic nerve head without significant pallor of the remaining neuroretinal rim. Neuroprotection is a novel strategy for treating disorders that affect the nervous system by preventing death of neurons. In glaucomatous optic neuropathy, the neurons that die are retinal ganglion cells. This article reviews the recent basic science relevant to neuroprotection, particularly with respect to retinal ganglion cell death in glaucomatous and other optic neuropathies.
Caching and prefetching for efficient video services in mobile networks (2015)

Cellular networks have witnessed phenomenal traffic growth recently fueled by new high speed broadband cellular access technologies. This growth is in large part driven by the emergence of the HTTP Adaptive Streaming (HAS) as a new video delivery method. In HAS, several qualities of the same videos are made available in the network so that clients can choose the quality that best fits their bandwidth capacity. This strongly impacts the viewing pattern of the clients, their switching behavior between video qualities, and thus beyond on content delivery systems.Our first contribution consists in providing an analysis of a real HAS dataset collected in France and provided by the largest French mobile operator. Firstly, we analyze and model the viewing patterns of VoD and live streaming HAS sessions and we propose a new cache replacement strategy, named WA-LRU. WA-LRU leverages the time locality of video segments within the HAS content. We show that WA-LRU improves the cache hit-ratio mostly at the loading phase while it reduces significantly the processing overhead at the cache.In our second contribution, we analyze and model the adaptation logic between the video qualities based on empirical observations. We show that high switching behaviors lead to sub optimal caching performance, since several versions of the same content compete to be cached. In this context we investigate the benefits of a Cache Friendly HAS system (CF-DASH) which aims at improving the caching efficiency in mobile networks and to sustain the quality of experience of mobile clients. We evaluate CF-dash based on trace-driven simulations and test-bed experiments. Our validation results are promising. Simulations on real HAS traffic show that we achieve a significant gain in hit-ratio that ranges from 15% up to 50%.In the second part of this thesis, we investigate the mobile video prefetching opportunities. Online media services are reshaping the way video content is watched. People with similar interests tend to request same content. This provides enormous potential to predict which content users are interested in. Besides, mobile devices are commonly used to watch videos which popularity is largely driven by their social success. We design a system, named "Central Predictor System (CPsys)", which aims at predicting and prefetching relevant content for each mobile client. To fine tune our prefetching system, we rely on a large dataset collected from a large mobile carrier in Europe. The rationale of our prefetching strategy is first to form a graph and build implicit or explicit ties between similar users. On top of this graph, we propose the Most Popular and Most Recent (MPMR) policy to predict relevant videos for each user. We show that CPSys can achieve high performance as regards prediction correctness and network utilization efficiency. We further show that CPSys outperforms other prefetching schemes from the state of the art. At the end, we provide a proof-of-concept implementation of our prefetching system.
Sea Ice Remote Sensing Using GNSS-R: A Review (2019)

Knowledge of sea ice is critical for offshore oil and gas exploration, global shipping industries, and climate change studies. During recent decades, Global Navigation Satellite System-Reflectometry (GNSS-R) has evolved as an efficient tool for sea ice remote sensing. In particular, thanks to the availability of the TechDemoSat-1 (TDS-1) data over high-latitude regions, remote sensing of sea ice based on spaceborne GNSS-R has been rapidly growing. The goal of this paper is to provide a review of the state-of-the-art methods for sea ice remote sensing offered by the GNSS-R technique. In this review, the fundamentals of these applications are described, and their performances are evaluated. Specifically, recent progress in sea ice sensing using TDS-1 data is highlighted including sea ice detection, sea ice concentration estimation, sea ice type classification, sea ice thickness retrieval, and sea ice altimetry. In addition, studies of sea ice sensing using airborne and ground-based data are also noted. Lastly, applications based on various platforms along with remaining challenges are summarized and possible future trends are explored. In this review, concepts, research methods, and experimental techniques of GNSS-R-based sea ice sensing are delivered, and this can benefit the scientific community by providing insights into this topic to further advance this field or transfer the relevant knowledge and practice to other studies.
New techniques for non-linear behavioral modeling of microwave/RF ICs from simulation and nonlinear microwave measurements (2003)

This paper compares and contrasts recent nonlinear behavioral modeling techniques designed for microwave and RFIC applications which arise in radio and communication systems, and in the design of broad-band nonlinear components used for microwave instrumentation. These techniques include dynamic neural networks and nonlinear time series models in the time-domain, nonlinear describing functions in the frequency domain, and envelope-based methods in mixed time and frequency domains. Approaches to generating these models from both simulation and nonlinear microwave measurements are reviewed.
From the Sacred to the Secular: Ethnic Identity and Monetary Value embodied in Jewish Ceremonial Textiles according to the Pinkassim of Amsterdam (2013)

In the last quarter of the nineteenth century the Jewish intelligentsia developed a historical and scholarly interest in material objects of Jewish culture. In new exhibitions they organized, ritual objects that had been associated exclusively with religious observance, were moved to the public domain and divested of their purely religious ritual function. In a secular setting, Judaica became an expression of Jewish ethnic identity defined by its surrounding and religion, and evoked a new appreciation as objets d’art that implicitly assumed a monetary market value. This article examines whether this expression of ethnic identity and aesthetic and monetary appreciation developed first in the context of nineteenth-century secularism. By presenting three case studies based on written sources, I argue that ethnic and monetary value were already manifest in prior centuries and underline the value of written sources for an understanding of the social and cultural historical context of Jewish ceremonial objects.
Crack-free GaN∕AlN distributed Bragg reflectors incorporated with GaN∕AlN superlattices grown by metalorganic chemical vapor deposition (2006)

A crack-free GaN∕AlN distributed Bragg reflector (DBR) incorporated with GaN∕AlN superlattice (SL) layers was grown on a c-plane sapphire substrate by metalorganic chemical vapor deposition. Three sets of half-wave layers consisting of 5.5 periods of GaN∕AlN SL layers and GaN layer were inserted in every five pairs of the 20 pair GaN∕AlN DBR structure to suppress the crack generation. The grown GaN∕AlN DBRs with SL insertion layers showed no observable cracks in the structure and achieved high peak reflectivity of 97% at 399nm with a stop band width of 14nm. Based on the x-ray analysis, the reduction in the in-plane tensile stress in the DBR structure with insertion of SL layers could be responsible for the suppression of crack formation and achievement of high reflectivity.
Asymmetric cell division and its integration with other developmental processes for artificial evolutionary systems (2004)

Artificial evolutionary techniques are more and more coupled with mechanisms abstracted from developmental biology. Artificial cells endowed with genetic regulatory networks were used to evolve and develop simulated creatures. This paper reports on the evolution of a simple moving creature using developmental mechanisms such as asymmetric cell division, genetic regulation and cell adhesion and physical interactions between cells. Surprisingly, artificial creatures were evolved able to move using only genetic regulatory networks without the need to employ neural controllers.
Oxidation of Drugs during Drug Product Development: Problems and Solutions (2022)

Oxidation is the second most common degradation pathway for pharmaceuticals, after hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex and produces a wider range of degradation products; oxidation is thus harder to control. The propensity of a drug towards oxidation is established during forced degradation studies. However, a more realistic insight into degradation in the solid state can be achieved with accelerated studies of mixtures of drugs and excipients, as the excipients are the most common sources of impurities that have the potential to initiate oxidation of a solid drug product. Based on the results of these studies, critical parameters can be identified and appropriate measures can be taken to avoid the problems that oxidation poses to the quality of a drug product. This article reviews the most common types of oxidation mechanisms, possible sources of reactive oxygen species, and how to minimize the oxidation of a solid drug product based on a well-planned accelerated study.