gebhart/patrepeval huggingface dataset:
Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains (1998)

Early region 3 (E3) of group C human adenoviruses (Ad) encodes several inhibitors of tumor necrosis factor alpha (TNF-alpha) cytolysis, including an E3 14.7-kDa protein (E3-14.7K) and a heterodimer containing two polypeptides of 10.4 and 14.5 kDa. To understand the mechanism by which the viral proteins inhibit TNF-alpha functions, the E3-14.7K protein was used to screen a HeLa cell cDNA library to search for interacting proteins in the yeast two-hybrid system. A novel protein containing multiple leucine zipper domains without any significant homology with any known protein was identified and has been named FIP-2 (for 14.7K-interacting protein). FIP-2 interacted with E3-14.7K both in vitro and in vivo. It colocalized with Ad E3-14.7K in the cytoplasm, especially near the nuclear membrane, and caused redistribution of the viral protein. FIP-2 by itself does not cause cell death; however, it can reverse the protective effect of E3-14.7K on cell killing induced by overexpression of the intracellular domain of the 55-kDa TNF receptor or by RIP, a death protein involved in the TNF-alpha and Fas apoptosis pathways. Deletion analysis indicates that the reversal effect of FIP-2 depends on its interaction with E3-14.7K. Three major mRNA forms of FIP-2 have been detected in multiple human tissues, and expression of the transcripts was induced by TNF-alpha treatment in a time-dependent manner in two different cell lines. FIP-2 has consensus sequences for several potential posttranslational modifications. These data suggest that FIP-2 is one of the cellular targets for Ad E3-14.7K and that its mechanism of affecting cell death involves the TNF receptor, RIP, or a downstream molecule affected by either of these two molecules.
Effect of Metallurgy on the Formation of Tribofilms and Wear Prevention (2017)

<div class="section abstract"><div class="htmlview paragraph">Different mechanical components in a vehicle can be made from different steel alloys with various surface treatments or coatings. Lubricant technology is needed to prevent wear and control friction on all of these different surfaces. Phosphorus compounds are the key additives that are used to control wear and they do this by forming tribofilms on surfaces. It has been shown that different operating conditions (pressures and sliding conditions) can influence the formation of tribofilms formed by different anti-wear additives. The effect of surface metallurgy and morphology on tribofilm formation is described in this paper. Our results show that additive technology can form proper tribofilms on various surfaces and the right combination of additives can be found for current and future surfaces.</div></div>
[Peritoneal lavage cytology in 66 patients with gastric carcinoma]. (2003)

Micrometastasis to the abdominal cavity, formed by free cancer cells exfoliated from the tumor, are significantly responsible for peritoneal dissemination. Serosal invasion and metastatic nodes have greater risk for positive cytology and implies poor prognosis. Peritoneal lavage cytology, if practiced in all gastric cancer patients being operated, can predict the operative effect and prognosis, increase the accuracy of clinical stage and provide information for further adjuvant therapy.
Simple and Efficient Secret Sharing Schemes for Sharing Data and Image (2015)

Secret sharing is a new alternative for outsourcing data in a secure way.It avoids the need for time consuming encryption decryption process and also the complexity involved in key management.The data must also be protected from untrusted cloud service providers.Secret sharing based solution provides secure information dispersal by making shares of the original data and distribute them among different servers.Data from the threshold number of servers can be used to reconstruct the original data.It is often impractical to distribute data among large number of servers.We have to achieve a trade off between security and efficiency.An optimal choice is to use a $(2,3)$ or $(2,4)$ threshold secret sharing scheme, where the data are distributed as shares among three or four servers and shares from any two can be used to construct the original data.This provides both security,reliability and efficiency.We propose some efficient and easy to implement secret sharing schemes in this regard based on number theory and bitwise XOR.These schemes are also suitable for secure sharing of images.Secret image sharing based on Shamir's schemes are lossy and involves complicated Lagrange interpolation.So the proposed scheme can also be effectively utilized for lossless sharing of secret images.
Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent (2007)

Indomethacin may injure the small intestine through a TLR4/MyD88-dependent pathway.
ECONOMIC BENEFITS OF MINERAL EXTRACTION FROM GEOTHERMAL BRINES (2006)

The economic benefits of the co-production of minerals from geothermal brines far exceeds the potential revenue stream from the sale of marketable by-products such as silica, zinc, manganese, lithium and a number of rare earths. Extraction of silica can avoid scaling problems often associated with many geothermal power projects and may allow for additional power production through the use of bottoming cycles or the use of the brine in direct use applications now impractical due to scaling problems. An additional benefit of silica removal is the opportunity to use the geothermal brine as a source of water for enhanced evaporative cooling – a technique that can significantly improve the summer power output from binary power plants employing air cooling for condensing the working fluid.
Android Malware Similarity Clustering using Method based Opcode Sequence and Jaccard Index (2019)

Recently, Android malicious code shows a trend to spread a large number of variants in a short time. This type of malicious code is mainly produced by reusing existing code, and the number of malicious codes has increased year by year despite the increased security of the OS. In this paper, we propose a clustering and classification method for Android malicious codes using a similarity algorithm in a lightweight manner. In this paper, among the APK internal files, Dex file is disassembled to extract Opcode Sequence in Method unit, and clustered similar Android malicious code with Jaccard Index using N-gram. Clustering results of Android malicious code collected in 1Q 2019 are presented and analyzed.
Research and implementation of TFT in EPS system (2013)

This paper presents a method of TFT storage and matching based on EPS bearer. The PF filter were stored in the bearer information unit according to the corresponding bearer identification t. At the same time in order to realize the IP packet data matching based on PF priority, we establish the PF information table in accordance with the priority of PF. Using PF information table can quickly locate the PF storage location and complete the IP packet matching. The PF storage according to the bearer identification and PF ID, TFT storage and modified completed in the corresponding bearer, avoid amount of work of sequential query, save the PF maintenance overhead.
Glicbawls - grey level image compression by adaptive weighted least squares (2022)

Glicbawls is an algorithm for losslessly and near-loesslessly compressing photographic greyscale images. It is based on locally adaptive least squares predictors, based on a two-dimensional exponentially fading memory. Despite being of moderate computational complexity, Glicbawls achieves excellent compression performance (e.g. the lenna image at 3.90 bits/pixel). The Glicbawls algorithm has been implemented in 1795 bytes of C code, making it feasible to include the decoder with the compressed images, and thus to determine a firm upper bound for the information content of any given image.
Late-Transition-Metal-Modified β-Mo<sub>2</sub>C Catalysts for Enhanced Hydrogenation during Guaiacol Deoxygenation (2017)

Molybdenum carbide has been identified as a promising bifunctional catalyst in the deoxygenation of a variety of pyrolysis vapor model compounds. Although high deoxygenation activity has been demonstrated, complementary hydrogenation activity has been limited, especially for lignin-derived, aromatic model compounds. The ability to control the relative site densities of acidic and hydrogenation functionalities represents a catalyst design challenge for these materials with the goal to improve hydrogenation activity under ex situ catalytic fast pyrolysis (CFP) conditions. Here we demonstrate that the addition of Pt and Ni to β-Mo2C resulted in an increase in the H*-site density with only a minor decrease in the acid-site density. In contrast, the addition of Pd did not significantly alter the H*- or acid-site densities. High conversions (>94%) and high selectivities to 0-oxygen products (>80%) were observed in guaiacol deoxygenation under ex situ CFP conditions (350 °C and 0.44 MPa H2) for all catalysts. Pt addition resulted in the greatest deoxygenation, and site-time yields to hydrogenated products over the Pt/Mo2C catalyst were increased to 0.048 s–1 compared to 0.015–0.019 s–1 for all other catalysts. The Pt/Mo2C catalyst demonstrated the highest hydrogenation performance, but modification with Ni also significantly enhanced hydrogenation performance, representing a promising lower-cost alternative.
Mutational status of epidermal growth factor receptor is the only predictor of clinical response to gefitinib treatment in non-small cell lung cancer (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4539 

The clinical profile of lung cancer in Hong Kong shows distinct characteristics. The incidences in both genders are comparable to those in Western populations with male (M):female (F) ratio of 2.4:1 in 2002. However, the majority of the women have never smoked and the smoker (SM):non-smoker (NS) ratio was 0.3:1, compared to 6.2:1 in male patients. Consistent with findings in various Asian populations, we have previously shown that mutations of the epidermal growth factor receptor (EGFR) in lung cancers are associated with adenocarcinomas, women and non-smokers. The purpose of this study was to examine the clinical correlates and EGFR mutational status (exons 18 to 21) of non-small cell lung cancer (NSCLC) in relation to clinical responses to the tyrosine kinase inhibitor gefitinib (Iressa). All patients who had resistant disease to conventional chemotherapy, had available clinical material (biopsy, fine needle aspiration, lavage or pleural effusion fluid) for mutation analysis, and who received gefitinib treatment in our institution were retrospectively evaluated. There were 27 F (26 NS, 1 SM) and 16 M (9 NS, 7 SM, p=0.002) aged 35-85 (median 64), and included 32 histologically confirmed adenocarcinomas (AD), 2 squamous and 9 NSCLC of advanced stage disease (IIIB and IV). Gefitinib (250mg/day) was given for 0.5 to 21.2 (median 3) months and patients were monitored for 0.5 to 26.4 (median 6.3) months. The median survival was 10.5 months (95% CI, 8.3-12.7) and one-year survival rate was 37.3%. There were 25 mutations (9 substitutions, 17 deletions) that resulted in amino acid changes from 20 F, 5 M (p=0.010), and 23 NS, 2 SM (p=0.052). One case showed both exon 19 deletion and exon 20 substitution. Common changes (exon 19 deletions, L858R) involved 88% of the mutants. 2 other cases showed silent mutations. Clinical response (CR) from gefitinib treatment was observed in 23 (53.5%) patients who showed either reduction of longest tumour diameter by ≥30%, improvement in performance status, and/or reduced serum carcinoembryonic antigen tumour marker. They included 17/27 (63%) female, 6/16 (37.5%) male, 19/35 (54.3%) NS, 4/8 (50%) SM, and 19/32 (59.4%) AD. Clinical response was correlated only with the EGFR mutation status (19/25 mutants, 4/18 wild types, p<0.001) but not patient gender, smoking history or tumor diagnosis. Survival analysis showed that patients with EGFR mutation had significantly better outcome than those without mutation (one-year survival rate 55.5% vs. 10.6%, p=0.013). Within the limits of the small patient number of this study, the data suggested that the EGFR mutational status is the only predictor of clinical response to gefitinib treatment for NSCLC in our population. (Supported by HKU CRCG 200507176201)
Pultruding Polyurethane Composite Profiles: Practical Guidelines for Injection Box Design, Component Metering Equipment and Processing (2005)

Unsaturated polyesters and vinyl esters have been the workhorse resins in the pultrusion industry for a quarter century or more. In efforts to expand their markets and differentiate their products, however, pultruders are continually seeking out new materials and processes, which can mitigate some of the limitations of traditional resins such as brittleness or slow reactivity. During the past three years polyurethane resins, which exhibit superior strength and damage-tolerance relative to traditional polyester and vinyl ester pultrusion resins, have been successfully commercialized. Such advantages do not come without new challenges as polyurethane resins require their own unique material handling and processing methods. There is a perception in the pultrusion industry that these requirements present an insurmountable barrier for practical application of polyurethane resins. This paper aims to address this perception by providing a practical discussion of injection box design, material handling, component metering equipment, die design, and process conditions used for pultruding polyurethane profiles. Using the guidelines presented in this paper, manufacturers can be confident of running a robust pultrusion process with continuous line operation.
Aging and Alcohol Abuse: Increasing Counselor Awareness (2005)

Alcohol abuse in older adulthood is a rapidly growing but often hidden problem. The authors provide an overview of the issues related to older adult alcohol abuse through a discussion of physiological, psychological, and social risk factors; an examination of appropriate assessment procedures; and an overview of factors related to treatment.
Cellular Uptake and Saccharide Chain Elongation of “Fluoro-amphiphilic” Glycosides (2005)

Abstract “Fluoro-amphiphilic” glycosides are practical alternatives for the preparation of oligosaccharides. Fluoro-amphiphilic saccharide primers possessing a hydrophilic sugar moiety and a fluorous tag could be taken up by cells and elongated by cellular enzymes. The elongated products were released by cells to the culture medium and could be easily separated from other components by simple extraction with a fluorous solvent.
Conditioning to dynamic data: an improved zonation approach (2001)

An optimization method for incorporating dynamic data into reservoir modelling is presented. It integrates a very typical feature of the zonation approach that is based upon dividing the reservoir model into subregions. Solving the optimization problem consists of adjusting the subregion pattern so that the reservoir model duplicates the observed dynamic behaviour. Unlike the traditional approach, permeabilities in subregions are not constant, but show spatial variations. A variogram model that is the same for all the subregions describes this variability. The suggested method allows for optimization of permeability distributions within the subregions while preserving the second-order statistics for the whole reservoir model as well as the spatial continuity between subregions. It remains as flexible as the traditional zonation approach although it can handle complex structures.
Deposition of Narrow, High Quality, Closely Spaced, but Isolated Conductors (2007)

Abstract Developed procedures to deposit narrow (&lt;100nm), closely spaced, low resistance conductors which exhibit good electrical isolation are demonstrated. The process parameters which limit how narrow a line can be deposited and the methods used to work-around these are discussed. For these depositions, 3pA ion beam current was used with a Mo(CO)6 precursor chemistry. The deposition method minimized the incorporation of non-conductive precursor by-products. To isolate adjacent conductors, a copper etch Credence FIB chemistry was used. The advantages of this procedure over the common practice when XeF2 chemistry is used is also discussed and demonstrated.
Talking, Listening, and Thinking Interactively Dialogue Experienced (2011)

By the fifth meeting — Leningrad, November 1984 — the group, in retrospect, seems to have matured to a point where it was ready to move to a deeper level of interaction, but not without some trauma or maybe because of it. In one of those unknowable experiences with cause and effect, this readiness coincided with the beginnings of a thaw in the Soviet-U.S. relationship, commencing in the summer of 1984.
<b>KFAS</b>: Exponential Family State Space Models in <i>R</i> (2017)

State space modeling is an efficient and flexible method for statistical inference of a broad class of time series and other data. This paper describes the R package KFAS for state space modeling with the observations from an exponential family, namely Gaussian, Poisson, binomial, negative binomial and gamma distributions. After introducing the basic theory behind Gaussian and non-Gaussian state space models, an illustrative example of Poisson time series forecasting is provided. Finally, a comparison to alternative R packages suitable for non-Gaussian time series modeling is presented.
On the study of MOSFET micro-sensors for electronic packaging (2007)

The purpose of this paper is to study the MOSFET stress sensor behaviors and to develop the related measurement methodology. With the newly developed technology, the piezoresistance coefficients of the MOSFET were extracted, and the strain and temperature effect induced MOSFET characteristics were obtained. The results of this study can be used to adjust the chip structure in a packaging so that the optimal packaging technology and material can be chosen, and accuracies of the numerical analysis can be verified through experimental data with the new technology studied in this paper.
Non-integrating gamma-retroviral vectors as a versatile tool for transient zinc-finger nuclease delivery (2014)

Designer nucleases, like zinc-finger nucleases (ZFNs), represent valuable tools for targeted genome editing. Here, we took advantage of the gamma-retroviral life cycle and produced vectors to transfer ZFNs in the form of protein, mRNA and episomal DNA. Transfer efficacy and ZFN activity were assessed in quantitative proof-of-concept experiments in a human cell line and in mouse embryonic stem cells. We demonstrate that retrovirus-mediated protein transfer (RPT), retrovirus-mediated mRNA transfer (RMT), and retrovirus-mediated episome transfer (RET) represent powerful methodologies for transient protein delivery or protein expression. Furthermore, we describe complementary strategies to augment ZFN activity after gamma-retroviral transduction, including serial transduction, proteasome inhibition, and hypothermia. Depending on vector dose and target cell type, gene disruption frequencies of up to 15% were achieved with RPT and RMT, and >50% gene knockout after RET. In summary, non-integrating gamma-retroviral vectors represent a versatile tool to transiently deliver ZFNs to human and mouse cells.
Selective Metabolite and Peptide Capture/Mass Detection Using Fluorous Affinity Tags (2007)

A new and general methodology is described for the targeted enrichment and subsequent direct mass spectrometric characterization of sample subsets bearing various chemical functionalities from highly complex mixtures of biological origin. Specifically, sample components containing a chemical moiety of interest are first selectively labeled with perfluoroalkyl groups, and the entire sample is then applied to a perfluoroalkyl-silylated porous silicon (pSi) surface. Due to the unique hydrophobic and lipophobic nature of the perfluorinated tags, unlabeled sample components are readily removed using simple surface washes, and the enriched sample fraction can then directly be analyzed by desorption/ionization on silicon mass spectrometry (DIOS-MS). Importantly, this fluorous-based enrichment methodology provides a single platform that is equally applicable to both peptide as well as small molecule focused applications. The utility of this technique is demonstrated by the enrichment and mass spectrometric analysis of both various peptide subsets from protein digests as well as amino acids from serum.
Programmable amplitude- and phase-modulated femtosecond laser pulses in the mid-infrared (2002)

We present a scheme to produce programmable phase- and amplitude-modulated femtosecond laser pulses in the mid-infrared regime of 3-10mum by difference frequency mixing. The 80-fs signal output of an optical parametric amplifier is shaped with a liquid-crystal mask and mixed in an AgGaS(2) crystal with a temporally stretched idler pulse. Without changing the mechanical alignment, we produce programmable amplitude modulations and chirped pulses at lambda=3mum with energy as high has thas 1muJ . This scheme, further, allows the generation of controllable pulse sequences. The results are in good agreement with theoretical simulations.
Effect of element mutual coupling on the capacity of fixed length linear arrays (2002)

The effect of element mutual coupling on the capacity of multiple-input-multiple-output (MIMO) antenna systems is demonstrated by considering a fixed-length linear array of half-wave dipoles. Mutual coupling between elements, which influences both the spatial correlation and the received signal-to-noise ratio (SNR), is taken into account by means of the impedance matrix. Monte Carlo simulations are performed for both single-sided (i.e., transmitting end or receiving end) and double-sided fading correlations. It is shown that mutual coupling results in substantially lower capacity and, hence, in reduced degrees of freedom.
Are BRCA1- and BRCA2-associated breast cancers different? Prognosis of BRCA1-associated breast cancer. (2000)

BRCA1-associated breast cancers present with histopathologic features that seem to confer an adverse prognosis, at least in certain subgroups. However, it is not clear whether BRCA1 status has an independent effect on outcome. Until further data become available, treatment for BRCA1-associated breast cancer should be determined by the same factors that influence therapy of nonhereditary disease.
Differences in Climbing-Specific Strength Between Boulder and Lead Rock Climbers (2012)

The purpose of this study was to compare maximal muscle strength and rapid force capacity of finger flexors between boulder and lead climbers of national-international level. Ten boulder (mean ± SD, age 27 ± 8 years) and 10 lead climbers (age 27 ± 6 years) volunteered for the study. Ten nonclimbers (age 25 ± 4 years) were also tested. Isometric maximal voluntary contraction (MVC) force and rate of force development (RFD) produced in "crimp" and "open-crimp" hand positions were evaluated on an instrumented hold. Climbers were stronger than nonclimbers. More interestingly, MVC force and RFD were significantly greater in boulder compared with lead climbers (p < 0.05), in both crimp and open-crimp positions. The RFD was the most discriminatory outcome, as the largest difference between boulder and lead climbers (34-38%) was observed for this variable. The RFD may reflect the specific requirements of bouldering and seems to be more appropriate than pure maximal strength for investigating muscle function in rock climbers.