gebhart/patrepeval huggingface dataset:
Study on bidirectional-charger for electric vehicle applied to power dispatching in smart grid (2016)

It will be one of the most important content to take the electric vehicle batteries as distributed energy storage units which can accept the power dispatching, and now bidirectional charger is the key power electronic device that has been used to connect power grid to the electric vehicle battery. In this paper, a two-stage bidirectional power converter made up of T-type neutral point clamped (NPC) three-phase three-level (TL) AC/DC and dual active bridge (DAB) DC/DC is studied, And the direct power control strategy is adopted to accept power dispatching from power grid. With high reliability, efficiency and high power quality as the goal, a novel space vector modulation (SVPWM) is proposed to avoid the terminal voltage distortion of bridge legs, and the series-parallel-connection DAB converter is presented to further improve efficiency. Finally, experimental results verify the feasibility of circuit topology and control strategy.
Maran Illustrated Computers Guided Tour (2005)

Coverage includes- Features a unique two-page spread, over 80 topics, dynamic illustrations, and useful tips that appeal to and engage visual learners and simplify the learning process. Provides extensive coverage of all of the latest technologies and trends in the world of computers, including Bluetooth, wi-fi networking, blogs, DVD burners, USB flash drives, and media devices including MP3 players, digital cameras, and camcorders, making it a great reference for all skill levels. maranGraphics trademark Diskman character provides a guided tour of each topic, making even the most challenging subjects fun and approachable Written using Visual Grammar, a proven method that combines instructions with full-color screen shots to provide the best synergistic learning experience available.
The Effect of Degree of Polymerization of Silicates on Their Interactions with Cations in Solution (1982)

The development of a better understanding of the role soluble silcates play in detergency, mineral beneficiation, enhanced oil recovery, etc., has led us to look carefully at the interactions of soluble silicate species with metal ions in solution. The acidity of ≡Si-OH increases as the complexity of the silica species increases, e.g., pKa for Si(OH)2O2= is 9.91± 0.04 whereas ≡Si-OH on silca gel has a pKa = 6.8± 0.2. Viewing the interaction of metal ions in solution with a soluble silica surface as an ion exchange process, one might expect differences dependent on the degree of polymerization of the silicate anion. Our results indicate that metal ion activities in solution are sensitive to factors related to the anion structure and pH value. The results support Iler's observation that silicate solution begins to absorb multivalent metal ions in solution at pH values roughly two units below the pH at which the metal hydroxide is precipitated
Body Pressure Sensing Mattress for Bedsore Prevention (2014)

We have developed an air mattress that prevents patients from developing pressure ulcers (bedsores), thereby improving their quality of life (QOL), promoting their rehabilitation, and reducing the burden of caregivers when changing a patient’s body position. Based on suggestions from medical professionals, our mattress is equipped with “Smart Rubber” (SR) sensors and two-balloon air cells. The sensors measure body pressure and the tension of the air cells is accordingly adjusted in order to fit to the patient’s body shape. This mattress disperses body pressure smoothly, provides comfortable bed rest and helps patients’ early ambulation.
Parametric Interpretation in Yorktalk. (1992)

The method of parametric interpretation used in the computer program Yorktalk, software that creates synthetic parameter files from phonological representations of speech, is explained. First, the design of the program is described, and the concept of exponency in prosodic analysis is explained as it is applied in the program. Then a hypothetical example of parametric analysis of a syllable is presented. Interpretation of nuclei, codas, and onsets are detailed, and diagrams are provided. The software's treatment of laterals and vowel allophony is given special attention. A 14-item bibliography is inOuded. (MSE) ***********************I.A:.******:,AA************************************ Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** Parametric Interpretation in Yorktalk* Richard Ogden PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY
Biotinidase deficiency: a treatable leukoencephalopathy (2004)

Objective: The clinical histories, outcomes and cerebral imaging have been reviewed for 12 patients with biotinidase deficiency.
Pulsed coherent population trapping with repeated queries for producing single-peaked high contrast Ramsey interference (2018)

A repeated query technique has been demonstrated as a new interrogation method in pulsed coherent population trapping for producing single-peaked Ramsey interference with high contrast. This technique enhances the contrast of the central Ramsey fringe by nearly 1.5 times and significantly suppresses the side fringes by using more query pulses (&gt;10) in the pulse cycle. Theoretical models have been developed to simulate Ramsey interference and analyze the characteristics of the Ramsey spectrum produced by the repeated query technique. Experiments have also been carried out employing a repeated query technique in a prototype rubidium clock to study its frequency stability performance.
TNF‐α‐inducing protein, a carcinogenic factor secreted from <i>H. pylori</i> , enters gastric cancer cells (2008)

TNF-alpha inducing protein (Tip alpha) is secreted from Helicobacter pylori (H. pylori): it is a potent inducer of TNF-alpha and chemokine genes, mediated through NF-kappaB activation, and it also induces tumor-promoting activity in Bhas 42 cells. To investigate the carcinogenic mechanisms of H. pylori with Tip alpha, we first examined how Tip alpha acts on gastric epithelial cells. We found that fluorescent-Tip alpha specifically bound to, and then entered, the cells in a dose- and temperature-dependent manner, whereas deletion mutant of Tip alpha (del-Tip alpha), an inactive form, neither bound to nor entered the cells, suggesting the presence of a specific binding molecule. Mutagenesis analysis of Tip alpha revealed that a dimer formation of Tip alpha with a disulfide bond is required for both specific binding and induction of TNF-alpha gene expression. A confocal laser scanning microscope revealed some Tip alpha in the nuclei, but del-Tip alpha was not present, which indicated that an active form of Tip alpha can penetrate the nucleus and may be involved in the induction of TNF-alpha gene expression. Examination of Tip alpha production and secretion in 28 clinical isolates revealed that H. pylori obtained from gastric cancer patients secreted Tip alpha in significantly higher amounts than did H. pylori from patients with chronic gastritis, suggesting that Tip alpha is an essential factor in H. pylori inflammation and cancer microenvironment in the human stomach. Tip alpha is thus a new carcinogenic factor of H. pylori that can enter the nucleus through a specific binding molecule, and its mechanism of action is completely different from that of CagA.
Stereoselective preparation of (R<sub>P</sub>)-8-hetaryladenosine-3′,5′-cyclic phosphorothioic acids (2007)

Cyclic adenosine monophosphate (cAMP) has been converted into its 8-bromo derivative and 2'O-TBDMS protected before activation of the phosphoric acid moiety with a reagent generated in situ from oxalyl chloride and DMF. Further reactions with primary amines furnished corresponding phosphoramidates with high stereoselectivity at the phosphorus atom. Cross-coupling reactions with the 8-bromopurine yielded 8-hetaryl derivatives. X-Ray analyses showed the amidates to possess the (S(P))-configuration. Carbon disulfide effected thiylation under strongly basic conditions stereospecifically provided the (R(P))-phosphorothioic acids.
Non-hydrolytic sol–gel routes to heterogeneous catalysts (2012)

Oxides and mixed oxides have a tremendous importance in the field of heterogeneous catalysis, serving either as catalysts or as supports for active species. The performance of a catalyst depends directly on its composition, texture, structure and surface properties, which have to be precisely controlled and adapted to each application. In this context, the sol-gel process is a unique tool for the preparation and understanding of catalytic materials, owing to its exceptional versatility. In the last 10 years, the non-hydrolytic sol-gel (NHSG) or non-aqueous sol-gel process based on nonhydrolytic condensations in nonaqueous media has established itself as a simple and powerful method for the design of a wide range of oxide, mixed oxide and hybrid materials with controlled composition, morphology, texture and structure. NHSG proved particularly interesting for the preparation of catalytic materials, notably mesoporous xerogels, single site catalysts and highly crystalline nanoparticles. This critical review addresses the application of NHSG to the preparation of heterogeneous catalysts, emphasizing the specificities of this process, and giving a comprehensive overview of the literature (251 references).
Anti‐tumor activity of tumor necrosis factor in combination with interferon‐γ is not affected by prior tolerization (1995)

Repetitive administration of low doses of tumor necrosis factor (TNF) results in a state of selective tolerance to some of its effects. We have demonstrated that tolerance does not impair the therapeutic efficacy of TNF against a syngeneic murine B16BL6 melanoma and allows a complete cure. Another study, performed with a distinct tumor model, came to apparently contradictory results. To clarify this, we investigated whether the outcome depended on the tumor type and on the inclusion of interferon-gamma (IFN gamma) in the treatment. Three syngeneic tumors of different histological origin, i.e., B16BL6 melanoma, Lewis lung carcinoma (LLC) and EL4 lymphoma, were compared in C57BL/6 mice. The anti-tumor efficacy of TNF against B16BL6 and EL4 was not impaired in tolerant mice, but the effect of TNF against LLC was slightly, though significantly, reduced. Inclusion of IFN gamma in the treatment regimen, however, abolished this difference and resulted in complete cure for all 3 tumor systems. As therapeutically optimal doses were lethal in normal mice, only tolerance allowed a long-term cure. We conclude that the influence of tolerance on the anti-tumor activity of TNF as a single agent depends on the tumor type; in combination therapy with IFN gamma, however, tolerance allowed us to dissociate lethal toxicity from anti-tumor activity, irrespective of the tumor type tested.
An Automated Seepage Meter for Streams and Lakes (2020)

Abstract We describe a new automatic seepage meter for use in soft bottom streams and lakes. The meter utilizes a thin‐walled tube that is inserted into the streambed or lakebed. A hole in the side of the tube is fitted with an electric valve. Prior to the test, the valve is open and the water level inside the tube is the same as the water level outside the tube. The test starts with closure of the valve, and the water level inside the tube changes as it moves toward the equilibrium hydraulic head that exists at the bottom of the tube. The time rate of change of the water level immediately after the valve closes is a direct measure of the seepage rate ( q ). The meter utilizes a precision linear actuator and a conductance circuit to sense the water level to a precision of about ±0.1 mm. The meter can also provide an estimate of vertical hydraulic conductivity ( K v ) if data are collected for a characteristic time. The detection limit for q depends on the vertical hydraulic head gradient. For K v = 1 m/day, q of about 2 mm/day can be measured. Results from a laboratory sand tank show excellent agreement between measured and true q , and results from a field site are similar to values from calculations based on independent measurements of K v and vertical head gradients. The meter can provide rapid (30 min) q measurements for both gaining and losing systems and complements other methods for quantifying surface water groundwater interactions.
Handbook of advanced radioactive waste conditioning technologies (2011)

Introduction. Part 1 Radioactive waste treatment processes and conditioning technologies: Compaction processes Incineration and plasma processes Application of inorganic cements Calcination and vitrification processes Historical development of vitrification Decommissioning of nuclear facilities and environmental remediation. Part 2 Advanced materials and technologies for the immobilisation of radioactive wastes: Geopolymers Glass matrices Ceramic matrices Waste packages Metal containers. Part 3 Long-term performance assessment and knowledge management techniques: Failure mechanisms of nuclear waste forms Long-term performance models Knowledge management techniques.
Nonclinical Development of ANX005: A Humanized Anti-C1q Antibody for Treatment of Autoimmune and Neurodegenerative Diseases (2017)

ANX005 is a humanized immunoglobulin G4 recombinant antibody against C1q that inhibits its function as the initiating molecule of the classical complement cascade. The safety and tolerability of ANX005 are currently being evaluated in a phase I trial in healthy volunteers ( www.clinicaltrials.gov Identifier: NCT03010046). Inhibition of C1q can be applied therapeutically in a broad spectrum of diseases, including acute antibody-mediated autoimmune disease, such as Guillain-Barré syndrome (GBS), and in chronic diseases of the central nervous system involving complement-mediated neurodegeneration, such as Alzheimer's disease (AD). To support the clinical development of ANX005, several studies were conducted to assess the pharmacology, pharmacokinetics, and potential toxicity of ANX005. ANX-M1, the murine precursor of ANX005, functionally inhibits the classical complement cascade both in vitro and in vivo, to protect against disease pathology in mouse models of GBS and AD. Toxicology studies with ANX005, itself, showed that intravenous administration once weekly for 4 weeks was well tolerated in rats and monkeys, with no treatment-related adverse findings. Serum levels of ANX005 in monkeys correlate with a reduction in free C1q levels both in the serum and in the cerebrospinal fluid. In summary, ANX005 has shown proof of concept in in vitro and in vivo nonclinical pharmacology models, with no toxicity in the 4-week repeat-dose studies in rats and monkeys. The no observed adverse effect level was 200 mg/kg/dose, which is 200-fold higher than the first-in-human starting dose of 1 mg/kg in healthy volunteers.
Using Nucleases to Stimulate Homologous Recombination (2004)

In essentially all organisms, double-strand breaks in chromosomal DNA stimulate repair by multiple mechanisms, including homologous recombination. It is possible to use site-specific reagents to produce a break or other recombinagenic damage at a unique site, which makes possible detailed analysis of the repair products. In addition, targeted mutagenesis and gene replacement are stimulated in the immediate vicinity of the break site. To utilize meganucleases with long recognition sequences, it is necessary to introduce the corresponding sequence prior to directed cleavage. The same is typically true of triplex-forming oligonucleotides that target polypurine-polypyrimidine tracts. Zinc-finger nucleases have the potential of being targetable to arbitrarily selected sites, owing to the flexibility of zinc finger recognition of DNA.
A DNA Nanostructure‐based Biomolecular Probe Carrier Platform for Electrochemical Biosensing (2010)

A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
An effector from the Huanglongbing-associated pathogen targets citrus proteases (2018)

The citrus industry is facing an unprecedented challenge from Huanglongbing (HLB). All cultivars can be affected by the HLB-associated bacterium 'Candidatus Liberibacter asiaticus' (CLas) and there is no known resistance. Insight into HLB pathogenesis is urgently needed in order to develop effective management strategies. Here, we use Sec-delivered effector 1 (SDE1), which is conserved in all CLas isolates, as a molecular probe to understand CLas virulence. We show that SDE1 directly interacts with citrus papain-like cysteine proteases (PLCPs) and inhibits protease activity. PLCPs are defense-inducible and exhibit increased protein accumulation in CLas-infected trees, suggesting a role in citrus defense responses. We analyzed PLCP activity in field samples, revealing specific members that increase in abundance but remain unchanged in activity during infection. SDE1-expressing transgenic citrus also exhibit reduced PLCP activity. These data demonstrate that SDE1 inhibits citrus PLCPs, which are immune-related proteases that enhance defense responses in plants.
Factors influencing teamwork and collaboration within a tertiary medical center (2012)

Hospital executives who are interested in improving collaboration should assess the work climate to ensure that employees are operating in a setting conducive to intra-organizational collaboration.
Elimination of thermally induced modal distortions in Faraday isolators for high power laser systems (2004)

Two methods of eliminating thermal lensing in Faraday isolators are theoretically and experimentally investigated: use of an ordinary negative lens and use of a compensating glass element with negative induced thermal lensing.
Modeling CD40-Based Molecular Communications in Blood Vessels (2014)

This paper presents a mathematical characterization of the main features of the molecular communication between platelets and endothelial cells via CD40 signaling during the initial phases of atherosclerosis, known also as atherogenesis. We demonstrate through laboratory experimentation that the release of soluble CD40L molecules from platelets in a fluid medium is enough to trigger expression of adhesion molecules on endothelial cell's surface; that is, physical contact between the platelets and the endothelial cells is not necessary. We also propose the mathematical model of this communication, and we quantify the model parameters by matching the experiment results to the model. In addition, this mathematical model of platelet-endothelium interaction, along with propagation models typical of blood vessels, is incorporated into a simulation platform. Analysis of the simulation results indicates that these enhancements render the simulator a useful tool upon which to base discussion for planning research, and has the potential to be an important step in the understanding, diagnosis, and treatment of cardiovascular diseases.
Engine Fleet-Management: The Use of Digital Twins From a MRO Perspective (2017)

Engine operating cost is a major contributor to the direct operating cost of aircraft. Therefore, the minimization of engine operating cost per flight-hour is a key aspect for airlines to operate successfully under challenging market conditions. The interaction between maintenance cost, operating cost, asset value, lease and replacement cost describes the area of conflict in which engine fleets can be optimized. State-of-the-art fleet management is based on advanced diagnostic and prognostic methods on engine and component level to provide optimized long-term removal and work-scoping forecasts on fleet level based on the individual operation. The key element of these methods is a digital twin of the active engines consisting of multilevel models of the engine and its components. This digital twin can be used to support deterioration and failure analysis, predict life consumption of critical parts and relate the specific operation of a customer to the real and expected condition of the engines on-wing and at induction to the shop. The fleet management data is constantly updated based on operational data sent from the engines as well as line maintenance and shop data. The approach is illustrated along the real application on the CFM56-5C, a mature commercial two-spool high bypass engine installed on the Airbus A340-300. It can be shown, that the new methodology results in major improvements on the considered fleets.
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy (2011)

Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin-proteasome system (UPS) for widespread degradation of outer membrane proteins. This is evidenced by an increase in K48-linked polyubiquitin on mitochondria, recruitment of the 26S proteasome and rapid degradation of multiple outer membrane proteins. The degradation of proteins by the UPS occurs independently of the autophagy pathway, and inhibition of the 26S proteasome completely abrogates Parkin-mediated mitophagy in HeLa, SH-SY5Y and mouse cells. Although the mitofusins Mfn1 and Mfn2 are rapid degradation targets of Parkin, we find that degradation of additional targets is essential for mitophagy. These results indicate that remodeling of the mitochondrial outer membrane proteome is important for mitophagy, and reveal a causal link between the UPS and autophagy, the major pathways for degradation of intracellular substrates.
Recruitment and the Role of Nuclear Localization in Polyglutamine-mediated Aggregation (1998)

The inherited neurodegenerative diseases caused by an expanded glutamine repeat share the pathologic feature of intranuclear aggregates or inclusions (NI). Here in cell-based studies of the spinocerebellar ataxia type-3 disease protein, ataxin-3, we address two issues central to aggregation: the role of polyglutamine in recruiting proteins into NI and the role of nuclear localization in promoting aggregation. We demonstrate that full-length ataxin-3 is readily recruited from the cytoplasm into NI seeded either by a pathologic ataxin-3 fragment or by a second unrelated glutamine-repeat disease protein, ataxin-1. Experiments with green fluorescence protein/polyglutamine fusion proteins show that a glutamine repeat is sufficient to recruit an otherwise irrelevant protein into NI, and studies of human disease tissue and a Drosophila transgenic model provide evidence that specific glutamine-repeat-containing proteins, including TATA-binding protein and Eyes Absent protein, are recruited into NI in vivo. Finally, we show that nuclear localization promotes aggregation: an ataxin-3 fragment containing a nonpathologic repeat of 27 glutamines forms inclusions only when targeted to the nucleus. Our findings establish the importance of the polyglutamine domain in mediating recruitment and suggest that pathogenesis may be linked in part to the sequestering of glutamine-containing cellular proteins. In addition, we demonstrate that the nuclear environment may be critical for seeding polyglutamine aggregates.