gebhart/patrepeval huggingface dataset:
Anisotropy induced signal waveform modulation of DC magnetron sputtered thin film disks (1986)

Thin films of Co-alloy, intended for use in longitudinal recording, were deposited onto variously prepared substrates by in-line DC magnetron sputtering. An anisotropy induced signal waveform modulation was observed through the use of a disk certifier and verified with vibrating sample magnetometer (VSM) orientation measurements and electron microscopic observation of grain structure. The partial low angle of incidence which can occur in in-line sputtering, the magnetic field generated from the magnetron target, the surface topography of substrates and the sputtering conditions, all affected the extent of preferred anisotropy in the films. By minimizing low angle of incidence sputtering, texturing the substrate surface circumferentially, and adjusting the processing conditions, we can eliminate not only the signal waveform modulation but also enhance the magnetic properties.
Miniaturised friction force measuring system for tribological research on magnetic storage devices (2002)

In this paper a silicon head slider suspension with integrated piezoresistive friction force sensors is presented. This device can be used for tribological research on magnetic rigid disk storage devices. Both the tangential and radial friction forces between the slider and disk, as well as a friction induced moment, can be measured simultaneously. Furthermore the normal load on the head slider can be measured. The paper focusses on design considerations and the realisation process of the suspension. Friction measurements are included to illustrate the feasibility of the system.
Dielectric-filled slotline bowtie antenna for breast cancer detection (2005)

An ultra-wideband dielectric-filled antenna has been designed for the purpose of breast cancer detection. The antenna geometry is a modified version of a slotline bowtie hybrid, which is immersed in a dielectric medium, and fed with an integrated ultra-wideband balun. Simulations were performed on both the balun and the antenna separately. The antenna had a simulated time domain near-field beamwidth of 32°. A return loss of 10 dB was obtained from 2.5 to 9 GHz, and 5 dB from 1 to 10 GHz. Both bandwidths were slightly smaller than simulated. A prototype was constructed and feasibility tests were performed on tumour models immersed in a breast phantom material. Measurements demonstrate detection of a 7 mm diameter tumour at a depth of 4 cm from the aperture.
Simulation-based Decision-making in Early Design Stages (2015)

The use of digital tools for building design has increased in the past few years with the introduction of building information modeling (BIM). However, the advantage of integrating decision support information into the early design stages has been little exploited. Such integration has the potential to enhance design solutions by providing knowledge of interactions and dependencies through explicit descriptions of the design space (DS), including dependence of energy performance on design parameters. The design space exploration assistance method (DSEAM) proposed here allows designers to evaluate their design using project specific simulation results and the DS formed by the potential alternative solutions to ensure deeper understanding of the calculated results. The response surface methodology, a metamodeling method, provides rapid results. Moreover, the approach visualizes the impact of design changes. The proposed approach is integrated into a computer-aided design environment to guide designers through the DS to find a well-performing solution. An office design example illustrates the benefits of DSEAM for decision-making.
Redox capacity and direct current electron conductivity in electroactive materials (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleRedox capacity and direct current electron conductivity in electroactive materialsChristopher E. D. Chidsey and Royce W. MurrayCite this: J. Phys. Chem. 1986, 90, 7, 1479–1484Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/j100398a051https://doi.org/10.1021/j100398a051research-articleACS PublicationsRequest reuse permissionsArticle Views1068Altmetric-Citations224LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Regional registration of whole slide image stacks containing major histological artifacts (2020)

Using multi-scale attention mechanism leads to a more robust and accurate solution to the problem of regional registration of whole slide images corrupted in some parts by major histological artifacts in the imaged tissue.
Dealing with Infertility Problems (1985)

Presented at the AMCAP Convention 5 October 1984.
New Mira Variables from the MACHO Galactic Bulge Fields, part II (2013)

We present a new sample of 525 Mira variables in the direction of the Galactic Bulge, expanding on previous samples of 69 and 500 objects, respectively, and thereby concluding our search for new Mira variables in the MACHO Galactic Bulge fields. 364 Miras of the present sample are reported as variable stars for the first time. We have cross-correlated our sample with the sample of Mira stars from the OGLE-III Catalog of Long-Period Variables (LPVs) in the Galactic Bulge and found 146 matches; MACHO and OGLE periods are in very good overall agreement. We present summary data for all stars of the present sample and give a statistical overview, comparing the properties of the MACHO and OGLE samples and enlarging on the analyses in our previous paper. Lightcurves, folded lightcurves and further details are available via the AAVSO International Variable Star Index (http://www.aavso.org/vsx/). Data of the complete sample of Mira variables from the MACHO Galactic Bulge fields, as presented in our papers (Bernhard, 2011; Huemmerich and Bernhard, 2012 and the present paper), can be found in the appendix.
DEMON: mining and monitoring evolving data (2001)

Data mining algorithms have been the focus of much research. In practice, the input data to a data mining process resides in a large data warehouse whose data is kept up-to-date through periodic or occasional addition and deletion of blocks of data. Most data mining algorithms have either assumed that the input data is static, or have been designed for arbitrary insertions and deletions of data records. We consider a dynamic environment that evolves through systematic addition or deletion of blocks of data. We introduce a new dimension, called the data span dimension, which allows user-defined selections of a temporal subset of the database. Taking this new degree of freedom into account, we describe efficient model maintenance algorithms for frequent item sets and clusters. We then describe a generic algorithm that takes any traditional incremental model maintenance algorithm and transforms it into an algorithm that allows restrictions on the data span dimension. We also develop an algorithm for automatically discovering a specific class of interesting block selection sequences. In a detailed experimental study, we examine the validity and performance of our ideas on synthetic and real datasets.
Super-hydrophobic and oloephobic crystalline coatings by initiated Chemical Vapor Deposition (2013)

Preferred crystallographic orientation (texture) in thin films frequently has a strong effect on the properties of the materials and it is important for stable surface properties. Organized molecular films of poly- perfluorodecylacrylate p(PFDA) were deposited by initiated Chemical Vapor Deposition (iCVD). The high tendency of p(PFDA) to crystallize has been fully retained in the polymers prepared by iCVD. The degree of crystallinity and the preferred orientation of the perfluoro side chains, either parallel or perpendicular to the surface, were controlled by tuning the CVD process parameters (i.e. initiator to monomer flow rate ratio, filament temperature, and substrate temperature). Superhydrophobicity (advancing water contact angle, WCA, of 160°, low hysteresis of 5°), and oleophobicity (advancing CA with mineral oil of 120°) were achieved. Low hysteresis was associated with high crystallinity, particularly when the orientation of the crystallites resulted in the perfluoro side groups being oriented parallel to the surface. The latter texture resulted in smoother film (RMS roughness &lt; 30 nm) than the texture with the chains oriented perpendicularly to the surface. This can be very advantageous for applications that require smooth but still crystalline films. © 2013 The Authors.
Formulation and rheological evaluation of ethosome-loaded carbopol hydrogel for transdermal application (2016)

The results indicate that suitable rheological properties of C974 could facilitate in achieving desired skin permeation of diclofenac while acting as an efficient carrier system for ethosomal vesicles.
PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow (2018)

PARP inhibitors have recently been approved as monotherapies for the treatment of recurrent ovarian cancer and metastatic <i>BRCA</i>-associated breast cancer, and ongoing studies are exploring additional indications and combinations with other agents. PARP inhibitors trap PARP onto damaged chromatin when combined with temozolomide and methyl methanesulfonate, but the clinical relevance of these findings remains unknown. PARP trapping has thus far been undetectable in cancer cells treated with PARP inhibitors alone. Here, we evaluate the contribution of PARP trapping to the tolerability and efficacy of PARP inhibitors in the monotherapy setting. We developed a novel implementation of the proximity ligation assay to detect chromatin-trapped PARP1 at single-cell resolution with higher sensitivity and throughput than previously reported methods. We further demonstrate that the PARP inhibitor-induced trapping appears to drive single-agent cytotoxicity in healthy human bone marrow, indicating that the toxicity of trapped PARP complexes is not restricted to cancer cells with homologous recombination deficiency. Finally, we show that PARP inhibitors with dramatically different trapping potencies exhibit comparable tumor growth inhibition at MTDs in a xenograft model of <i>BRCA1</i>-mutant triple-negative breast cancer. These results are consistent with emerging clinical data and suggest that the inverse relationship between trapping potency and tolerability may limit the potential therapeutic advantage of potent trapping activity. IMPLICATIONS: PARP trapping contributes to single-agent cytotoxicity of PARP inhibitors in both cancer cells and healthy bone marrow, and the therapeutic advantage of potent trapping activity appears to be limited.
Human lymphoblastoid interferon for clinical trials: large scale purification and safety tests. (1983)

Human lymphoblastoid cell lines are one of the best sources for the production of large amounts of human interferon for clinical trials. The potential risk of using transformed cell lines for production of a substance for human use can be overcome by an extensive purification of the interferon to a high degree, and by carefully testing the final product for DNA content and toxic materials. In previous reports we described a method for large scale production of interferon by a human lymphoblastoid cell line (Namalva). In this report a system for large scale purification of Namalva interferon and safety tests is presented. The procedure consists of three main steps: 1. Concentration of crude interferon by ultrafiltration. II. Gel filtration on Sephadex G-75 or Ultrogel AcA 54 columns. III. Affinity chromatography on anti-interferon antibody column. All steps were adapted for the processing of batches of hundreds of litres and can be easily further scaled-up. The final highly purified product undergoes a series of quality control tests such as purity, sterility, toxicity, pyrogenicity and DNA content. After passing all tests the IFN is released for clinical trials.
Knockout of the Erythromycin Biosynthetic Cluster Gene, <i>eryBI</i> , Blocks Isoflavone Glucoside Bioconversion during Erythromycin Fermentations in <i>Aeromicrobium erythreum</i> but Not in <i>Saccharopolyspora erythraea</i> (2008)

Isoflavone glucosides are valuable nutraceutical compounds and are present in commercial fermentations, such as the erythromycin fermentation, as constituents of the soy flour in the growth medium. The purpose of this study was to develop a method for recovery of the isoflavone glucosides as value-added coproducts at the end of either Saccharopolyspora erythraea or Aeromicrobium erythreum fermentation. Because the first step in isoflavone metabolism was known to be the conversion of isoflavone glucosides to aglycones by a beta-glucosidase, we chose to knock out the only beta-glucosidase gene known at the start of the study, eryBI, to see what effect this had on metabolism of isoflavone glucosides in each organism. In the unicellular erythromycin producer A. erythreum, knockout of eryBI was sufficient to block the conversion of isoflavone glucosides to aglycones. In S. erythraea, knockout of eryBI had no effect on this reaction, suggesting that other beta-glucosidases are present. Erythromycin production was not significantly affected in either strain as a result of the eryBI knockout. This study showed that isoflavone metabolism could be blocked in A. erythreum by eryBI knockout but that eryBI knockout was not sufficient to block isoflavone metabolism in S. erythraea.
High bit-precision image acquisition and reconstruction by planned sensor distortion (2014)

We present a novel framework for high bit-precision image acquisition and reconstruction. This framework is designed based on the inherent Markov property of image signals. In acquisition stage, we add planned sensor distortion (PSD) to the analog image signal before feeding it to A/D converters (or quantizers) in camera sensor. In reconstruction stage, the acquired quantized pixel values are jointly combined to get the reconstructed signal with reduced uncertainty range. Advantages of proposed PSD framework include 1) simplicity: it does not require any change to the core hardware of existing A/D converters; 2) effectiveness: experiment results demonstrate significant PSNR gain over traditional methods (up to 10 dB when quantizer bit-depth is relatively low); and 3) generality: this framework can also be applied for acquisition of other analog signals, including audio, video, etc.
Adaptive packet forwarding for relative differentiated services and categorized packet video (2002)

We explore a methodology to divide an application's data into several categories and send them through different IP differentiated services vices (DiffServ) grades. The issues are motivated by a futuristic infrastructure wherein the Internet service provider charges different prices to packets going through different service grades. This paper discusses how a subscriber of the DiffServ can assign different grades to real-time video packets on the basis of the packets' relative importance under the constraint of communication expenses. For relative DiffServ, we present an adaptive packet forwarding mechanism to preserve the performance ratio among service grades persistently over different time scales. Through experiments we observe how this packet forwarding mechanism improves the the quality of the application that maps the packets into the different service grades. In the experiment the end-to-end performance is evaluated by the error resilient packet video transmission using ITU-T H.263+ codec over a simulated Diffserv network.
Role of Monitoring Devices in Prevention of Anesthetic Mishaps (1989)

Anesthesiologist-reviewers examined 1,175 anesthetic-related closed malpractice claims from 17 professional liability insurance companies. The claims were filed between 1974 and 1988. The reviewers were asked to determine if the negative outcome was preventable by proper use of additional monitoring devices available at the time of the review even if not available at the time the incident occurred, and if so, which devices could have been preventative. In 1,097 cases sufficient information was available to make a judgment regarding preventability of the morbidity or mortality by application of additional monitoring devices. It was determined that 31.5% of the negative outcomes could have been prevented by application of additional monitors. Using the insurance industry's scale of 0 (no injury) to 9 (death), the median severity of injury for incidents deemed preventable was 9 compared with 5 for those deemed not preventable (P less than 0.01, scale detailed in text). The severity of injury scores were the same for preventable mishaps occurring during regional or general anesthesia, suggesting that additional monitoring devices may be equally efficacious in preventing serious negative outcomes during either regional or general anesthesia. The judgements or settlements of the incidents judged preventable by additional monitoring were 11 times more costly (P less than 0.01) than those mishaps not judged preventable. The monitors determined by the reviewers to be most useful in mishap prevention were pulse oximetry plus capnometry. Applied together, these two technologies were considered potentially preventative in 93% of the preventable mishaps.(ABSTRACT TRUNCATED AT 250 WORDS)
Analysis the "Resource-Structure-Function" of City Innovation Development (2011)

The coordinating development among the resource,structure and function(RSF) of city is the optimization path for city innovation development.This paper proposes that resource difference,the imbalanced relationship between social structure and economic structure, especially the unreasonable structure of industry structure,will restrict the realization of function orientation for city innovation development. By the accuracy position and reasonable plan of the city characteristics resource management,the city will extend the history connotation of city development,will optimize and adjust the social structure and economical structure,will change the economical growth style,will realizie the function orientation of city innovation development,will make sure city personnel enjoy economy grows fruit and will satisfy city personal allround development.
Mechanisms of chromium toxicity, carcinogenicity and allergenicity: Review of the literature from 1985 to 2000 (2001)

Laboratory and clinical reports about the pathogenesis of the carcinogenicity and allergenicity of chromium compounds published between 1985 and 2000 have been reviewed as a basis for consideration of the pathogenetic mechanisms involved. There is good evidence from the clinic and the laboratory that Cr[VI] is the ion responsible for most of the toxic actions, although much of the underlying molecular damage may be due to its intracellular reduction to the even more highly reactive and short-lived chemical species Cr[III] and Cr[V]. Exposure to Cr[VI] can result in various point mutations in DNA and to chromosomal damage, as well as to oxidative changes in proteins and to adduct formation. The relative importance of these effects of chromium ions and of the free oxidising radicals they may generate in the body in causing tumours and allergic sensitisation remain to be demonstrated. Biochemical studies of the DNA-damaging effects and of the pathogenesis of the allergic reactions to chromium ions have not kept up with advances in understanding of the molecular basis of the effects of other carcinogens and allergens.
The Clinical Relevance of Chemosensitivity Testing in Ovarian Cancer (1998)

The aim of this study was to assess the role of in vitro chemosensitivity testing in ovarian cancer using the MTT assay. Cells were separated from solid biopsy or ascitic fluid samples from 73 patients with ovarian adenocarcinoma, FIGO stage III to IV, on presentation. A 48 h drug exposure was followed by the MTT assay to determine sensitivity. Patients were treated by conventional regimens containing platinum. There was a marked variation in sensitivity to the platinum drugs between individual patients. Clinical data were available for 37 patients. Eleven out of seventeen (65%) patients in the sensitive group had a complete response to therapy, compared with 3 out of 20 (15%) in the resistant group (p = 0.005). The overall survival rates were 36% for the sensitive group compared with 18% for the resistant group (p = 0.37). This study suggests that chemosensitivity testing in ovarian cancer may be effective in improving initial clinical response.
Microfluidic on-chip immunohistochemistry directly from a paraffin-embedded section (2018)

We present here a novel microfluidic platform that can perform microfluidic on-chip immunohistochemistry (IHC) processes on a formalin-fixed paraffin-embedded section slide. Unlike previous microfluidic IHC studies, our microfluidic chip made of organic solvent-resistant polyurethane acrylate (PUA) is capable of conducting on-chip IHC processes consecutively. A narrow channel wall structure of the PUA chip shows effective sealing by pressure-based reversible assembly with a section slide. We performed both on-chip IHC and conventional IHC processes and compared the IHC results based on the immunostaining intensity. The result showed that the effects of the on-chip deparaffinization, antigen retrieval, and immunoreaction processes on the IHC result were equivalent to conventional methods while reducing the total process time to less than 1/2. The experiment with breast cancer tissue shows that human epidermal growth factor receptor 2 (HER2) classification can be performed by obtaining a clearly distinguishable immunostaining intensity according to the HER2 expression level. We expect our on-chip microfluidic platform to provide a facile technique suitable for miniaturized, automated, and precise diagnostic devices, including a point-of-care device.
Simulation of Dark Network Scene Based on the Big Data Environment (2018)

In the era of big data, the amount of information on dark network resources has exploded. Massive dark network data contain abundant information. To detect dark network resources and obtain dark network information, in-depth understanding of the dark network is a prerequisite. However, due to the high anonymity of dark network, it is usually difficult to be found by traditional search engines. Users need to register strictly and use specific tools to log in dynamically. In this paper, we explore the simulation of dark network scene in the big data environment. The Tor network is built on the openstack platform, which simulate the dark network scene. By using wireshark software to analyze network traffic, and using nmon tool to analyze network performance, the results show that the dark network scene can be simulated realistically.