gebhart/patrepeval huggingface dataset:
Reanimating the dead (2003)

Facial reconstruction for postmortem identification of humans from their skeletal remains is a challenging and fascinating part of forensic art. The former look of a face can be approximated by predicting and modeling the layers of tissue on the skull. This work is as of today carried out solely by physical sculpting with clay, where experienced artists invest up to hundreds of hours to craft a reconstructed face model. Remarkably, one of the most popular tissue reconstruction methods bears many resemblances with surface fitting techniques used in computer graphics, thus suggesting the possibility of a transfer of the manual approach to the computer. In this paper, we present a facial reconstruction approach that fits an anatomy-based virtual head model, incorporating skin and muscles, to a scanned skull using statistical data on skull / tissue relationships. The approach has many advantages over the traditional process: a reconstruction can be completed in about an hour from acquired skull data; also, variations such as a slender or a more obese build of the modeled individual are easily created. Last not least, by matching not only skin geometry but also virtual muscle layers, an animatable head model is generated that can be used to form facial expressions beyond the neutral face typically used in physical reconstructions.
Learning similarity functions for topic detection in online reputation monitoring (2014)

Reputation management experts have to monitor--among others--Twitter constantly and decide, at any given time, what is being said about the entity of interest (a company, organization, personality...). Solving this reputation monitoring problem automatically as a topic detection task is both essential--manual processing of data is either costly or prohibitive--and challenging--topics of interest for reputation monitoring are usually fine-grained and suffer from data sparsity. We focus on a solution for the problem that (i) learns a pairwise tweet similarity function from previously annotated data, using all kinds of content-based and Twitter-based features; (ii) applies a clustering algorithm on the previously learned similarity function. Our experiments indicate that (i) Twitter signals can be used to improve the topic detection process with respect to using content signals only; (ii) learning a similarity function is a flexible and efficient way of introducing supervision in the topic detection clustering process. The performance of our best system is substantially better than state-of-the-art approaches and gets close to the inter-annotator agreement rate. A detailed qualitative inspection of the data further reveals two types of topics detected by reputation experts: reputation alerts / issues (which usually spike in time) and organizational topics (which are usually stable across time).
Solubility and phase separation of poly(<scp>L,D</scp>‐lactide) copolymers (2008)

Abstract In this study, the solubility and precipitation properties of medical‐grade stereocopolymers were investigated. The solubility of the polymers was tested with eight different organic solvents and four nonsolvents. The solubility of poly( L,D ‐lactide) stereocopolymers was highly dependent on the L / D ratio of the copolymer. The phase‐separation ability was tested by cloud‐point titration with a solvent and a nonsolvent. The solvent was in all cases dichloromethane, and the nonsolvents were n ‐hexane, methanol, ethanol, and isopropyl alcohol. The results showed that n ‐hexane was the most efficient nonsolvent. Methanol and ethanol showed quite similar precipitation properties. Isopropyl alcohol was the least efficient nonsolvent of those studied. Also, the L / D ratio of the copolymer had an effect on the precipitation properties. The precipitation happened most easily when the L content was high. The molecular weight of the copolymer had only a slight effect on the phase separation. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Impact of adding prophylactic probiotics to a bundle of standard preventative measures for <i>Clostridium difficile</i> infections: enhanced and sustained decrease in the incidence and severity of infection at a community hospital (2013)

Specific probiotic product added to SPM and antibiotic stewardship activities resulted in a further reduction in CDI rates and was shown to be safe.
<i>ETHYLENE RESPONSE FACTOR 74</i> (<i>ERF74</i>) plays an essential role in controlling a respiratory burst oxidase homolog D (RbohD)‐dependent mechanism in response to different stresses in Arabidopsis (2016)

Recent studies indicate that the ETHYLENE RESPONSE FACTOR VII (ERF-VII) transcription factor is an important regulator of osmotic and hypoxic stress responses in plants. However, the molecular mechanism of ERF-VII-mediated transcriptional regulation remains unclear. Here, we investigated the role of ERF74 (a member of the ERF-VII protein family) by examining the abiotic stress tolerance of an ERF74 overexpression line and a T-DNA insertion mutant using flow cytometry, transactivation and electrophoretic mobility shift assays. 35S::ERF74 showed enhanced tolerance to drought, high light, heat and aluminum stresses, whereas the T-DNA insertion mutant erf74 and the erf74;erf75 double mutant displayed higher sensitivity. Using flow cytometry analysis, we found that erf74 and erf74;erf75 lines lack the reactive oxygen species (ROS) burst in the early stages of various stresses, as a result of the lower expression level of RESPIRATORY BURST OXIDASE HOMOLOG D (RbohD). Furthermore, ERF74 directly binds to the promoter of RbohD and activates its expression under different abiotic stresses. Moreover, induction of stress marker genes and ROS-scavenging enzyme genes under various stress conditions is dependent on the ERF74-RbohD-ROS signal pathway. We propose a pathway that involves ERF74 acting as an on-off switch controlling an RbohD-dependent mechanism in response to different stresses, subsequently maintaining hydrogen peroxide (H<sub>2</sub> O<sub>2</sub> ) homeostasis in Arabidopsis.
Material Characterization of Arbitrarily Shaped Dielectrics Based on Reflected Pulse Characteristics (2015)

The relative permittivity of materials is extracted using time domain radar pulse reflection measurements. The pulse reflected from an arbitrarily shaped dielectric object is compared with that reflected from its metallic equivalent to determine the object's dielectric constant. The proposed method achieves accuracies of over 85% for permittivity and within 2 mm for material thickness estimations. Using the proposed technique, the complex relative permittivity for various objects is extracted over a frequency range from 3 to 10 GHz. This method has been applied to determine the permittivity of a ridge of sand and to dielectric imaging.
Supramolecular Chemistry (2022)

<italic>Supramolecular Chemistry</italic> provides an illustrated introduction to one of the fundamental areas of modern chemical research, the concepts of which are essential to understanding interactions between molecules. It provides cutting-edge examples and applications to show the relevance of the chemistry being described to current research and industry. The first chapter provides an introduction to the topic. The next chapter looks at the binding of charged guests. This is followed by a chapter about the binding of neutral guests. The text moves on to consider self-assembly. It finishes with an assessment of mechanically interlocked molecules.
Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents (2012)

Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein disulfide isomerase (PDI) is an oxidoreductase that has recently been shown to participate in thrombus formation. While currently available antithrombotic agents inhibit either platelet aggregation or fibrin generation, inhibition of secreted PDI blocks the earliest stages of thrombus formation, suppressing both pathways. Here, we explored extracellular PDI as an alternative target of antithrombotic therapy. A high-throughput screen identified quercetin-3-rutinoside as an inhibitor of PDI reductase activity in vitro. Inhibition of PDI was selective, as quercetin-3-rutinoside failed to inhibit the reductase activity of several other thiol isomerases found in the vasculature. Cellular assays showed that quercetin-3-rutinoside inhibited aggregation of human and mouse platelets and endothelial cell-mediated fibrin generation in human endothelial cells. Using intravital microscopy in mice, we demonstrated that quercetin-3-rutinoside blocks thrombus formation in vivo by inhibiting PDI. Infusion of recombinant PDI reversed the antithrombotic effect of quercetin-3-rutinoside. Thus, PDI is a viable target for small molecule inhibition of thrombus formation, and its inhibition may prove to be a useful adjunct in refractory thrombotic diseases that are not controlled with conventional antithrombotic agents.
An ultra broadband DC-12 GHz 4-bit GaAs monolithic digital attenuator (2002)

A novel FET-based switchable attenuator circuit has been developed which can easily be realized in MMIC (monolithic microwave integrated circuit) form. The resulting 4-bit 1 dB step attenuator has achieved the broadest bandwidth (DC-12 GHz) yet reported. Impressive attenuation accuracy has been preserved over the 15 dB attenuation range and full 12 GHz bandwidth while the reference insertion loss at 12 GHz is only 3.5 dB. The die size of 1.2*0.8 mm (48*32 mils) represents a significant reduction in size and cost over all prior realizations of this function.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Quantitative Depth Profiling of Layered Samples Using Phase-Modulation FT-IR Photoacoustic Spectroscopy (1996)

In phase-modulation FT-IR spectroscopy, all wavelengths in a spectrum are modulated at the same frequency and in phase. This factor makes the use of photoacoustic phase data for depth profiling samples much easier in phase modulation than in rapid scan. A method to quantitatively measure layer thickness by using the phase of a substrate spectrum peak is demonstrated with a series of samples consisting of thin polymer Alms on substrates. Additions to the basic method are demonstrated that extend its application to cases where the substrate peak is overlapped by a spectrum peak of the surface film. A linear relationship between phase angle and layer thickness extending to thicknesses greater than twice the thermal diffusion length is demonstrated. Representations of phase modulation data as a family of angle-specific spectra, as magnitude vs. phase curves, and as a power spectrum and phase spectrum pair, each of which is useful for different aspects of depth profiling, are discussed. Calculating these representations from a single pair of orthogonal interferograms is described.
Genomic Characterization of Orf Virus Strain D1701-V (Parapoxvirus) and Development of Novel Sites for Multiple Transgene Expression (2019)

The <i>Orf virus</i> (ORFV; <i>Parapoxvirus</i>) strain D1701 with an attenuated phenotype and excellent immunogenic capacity is successfully used for the generation of recombinant vaccines against different viral infections. Adaption for growth in Vero cells was accompanied by additional major genomic changes resulting in ORFV strain variant D1701-V. In this study, restriction enzyme mapping, blot hybridization and DNA sequencing of the deleted region s (A, AT and D) in comparison to the predecessor strain D1701-B revealed the loss of 7 open reading frames (ORF008, ORF101, ORF102, ORF114, ORF115, ORF116, ORF117). The suitability of deletion site D for expression of foreign genes is demonstrated using novel synthetic early promoter eP1 and eP2. Comparison of promoter strength showed that the original <i>vegf-e</i> promoter Pv as well as promoter eP2 display an up to 11-fold stronger expression than promoter eP1, irrespective of the insertion site. Successful integration and expression of the fluorescent marker genes is demonstrated by gene- and insertion-site specific PCR assays, fluorescence microscopy and flow cytometry. For the first time ORFV recombinants are generated simultaneously expressing transgenes in two different insertion loci. That allows production of polyvalent vaccines containing several antigens against one or different pathogens in a single vectored ORFV vaccine.
Identification of a large Myc-binding protein that contains RCC1-like repeats (1998)

The protooncogene MYC plays an important role in the regulation of cellular proliferation, differentiation, and apoptosis and has been implicated in a variety of human tumors. MYC and the closely related MYCN encode highly conserved nuclear phosphoproteins (Myc and NMyc) that apparently function as transcription factors in the cell. We have identified a large and highly conserved nuclear protein that interacts directly with the transcriptional activating domain of Myc (designated "protein associated with Myc" or Pam). Pam contains an extended amino acid sequence with similarities to a protein known as regulator of chromosome condensation (RCC1), which may play a role in the function of chromatin. The gene encoding Pam (PAM) is expressed in all of the human tissue examined, but expression is exceptionally abundant in brain and thymus. Pam binds specifically to Myc, but not NMyc. The region in Myc required for binding to Pam includes a domain that is essential for the function of Myc and that is frequently mutated in Burkitt's lymphomas. PAM is located within a 300-kb region on chromosome 13q22.
Single carbon fiber as a sensing element in pressure sensors (2006)

The principal and innovative concept of this research is the replacement of piezoresistors in the current piezoresistive pressure sensors with carbon fibers. The piezoresistive characteristics of carbon fibers can play the same role as piezoresistors in current pressure sensors. The main structure of pressure sensors was built by back side etching on a silicon-on-insulator wafer to create a square diaphragm. Dielectrophoresis was used for the alignment and deposition of carbon fiber across the gap between two electrodes. The fabricated pressure sensors clearly showed linear response to applied pressure, so the feasibility of carbon-fiber-based pressure sensors was demonstrated.
Hepatocellular Carcinoma (2019)

Primary liver cancer is the fourth most common tumor worldwide. Hepatocellular carcinoma occurs mainly in the context of cirrhosis, hepatitis B or C virus infection, or nonalcoholic steatohepatitis. Underlying liver disease limits therapeutic efficacy.
Mesenchymal Stem Cells for Regenerative Medicine (2019)

In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules, they are not detected by immune surveillance and do not lead to graft rejection after transplantation. These properties make them competent biomedical candidates, especially in tissue engineering. We present a brief overview of MSC extraction methods and subsequent potential for differentiation, and a comprehensive overview of their preclinical and clinical applications in regenerative medicine, and discuss future challenges.
A submicron VLSI memory with a 4b-at-a-time built-in ECC circuit (1984)

THIS PAPER WILL REPORT ON AN experimental 1Mb dynamic memory, utilizing a 4 bit-at-a-time Error Checking and Correcting (ECC) circuit, and a high-sensitivity distributed sense circuit. A 1Mb DRAM using a 20μ^2 cell was designed and fabricated with an 0.8~ CMOS process
Evaluation of essential powder properties through complementary particle size analysis methods for laser powder bed fusion of polymers (2020)

The resolution of complex parts produced by laser powder bed fusion of polymers (PBF-LB/P) is defined significantly by the shape and size distribution of the feedstock powder. Its analysis is usually performed by optical measurement systems such as laser diffraction or image analysis. In this study, the most relevant particle size parameters will be extracted from a set of different measuring methods, as well as the Hausner ratio and finally discussed regarding safe and successful processability. Extracted data include the sphericity, fine fraction, volume- and number-weighted diameter distributions, and statistical significance analysis, including comparison of PA12 and carbon-black-additivated PA12. The presented results should give researchers a first impression about the suitability of polymer powders for PBF-LB/P, based on powder feedstock characterization.
New approaches to reliable wireless body area networks (2011)

In this paper we present and contrast two approaches, Cooperative Network Coding (CNC) and Cooperative Diversity Coding (CDC) to achieving reliable wireless body area networks. CNC combines cooperative communications and network coding, while CDC combines cooperative communication and diversity coding. These approaches also provide enhanced throughput and transparent self-healing which are desirable features that Wireless Body Area Networks should offer. Additionally, these feed-forward techniques are especially suitable for real-time applications, where retransmissions are not an appropriate alternative. Although, these techniques provide similar benefits, simulation results show that CDC provides higher throughput than CNC because of the fact that the network topology is known and few hops between the source and destination. Moreover, CDC has lower complexity, since the source and destination nodes know the coding coefficients.
Exploring the Benefits of Augmented Reality Documentation for Maintenance and Repair (2010)

We explore the development of an experimental augmented reality application that provides benefits to professional mechanics performing maintenance and repair tasks in a field setting. We developed a prototype that supports military mechanics conducting routine maintenance tasks inside an armored vehicle turret, and evaluated it with a user study. Our prototype uses a tracked headworn display to augment a mechanic's natural view with text, labels, arrows, and animated sequences designed to facilitate task comprehension, localization, and execution. A within-subject controlled user study examined professional military mechanics using our system to complete 18 common tasks under field conditions. These tasks included installing and removing fasteners and indicator lights, and connecting cables, all within the cramped interior of an armored personnel carrier turret. An augmented reality condition was tested against two baseline conditions: the same headworn display providing untracked text and graphics and a fixed flat panel display representing an improved version of the laptop-based documentation currently employed in practice. The augmented reality condition allowed mechanics to locate tasks more quickly than when using either baseline, and in some instances, resulted in less overall head movement. A qualitative survey showed that mechanics found the augmented reality condition intuitive and satisfying for the tested sequence of tasks.
Effect of enalapril (MK-421), an orally active angiotensin I converting enzyme inhibitor, on blood pressure, active and inactive plasma renin, urinary prostaglandin E<sub>2</sub>, and kallikrein excretion in conscious rats (1984)

The angiotensin I converting enzyme (ACE) inhibitor enalapril (MK-421), at a dose of 1 mg/kg or more by gavage twice daily, effectively inhibited the pressor response to angiotensin I for more than 12 h and less than 24 h. Plasma renin activity (PRA) did not change after 2 or 4 days of treatment at 1 mg/kg twice daily despite effective ACE inhibition, whereas it rose significantly at 10 mg/kg twice daily. Blood pressure fell significantly and heart rate increased in rats treated with 10 mg/kg of enalapril twice daily, a response which was abolished by concomitant angiotensin II infusion. However, infusion of angiotensin II did not prevent the rise in plasma renin. Enalapril treatment did not change urinary immunoreactive prostaglandin E2 (PGE2) excretion and indomethacin did not modify plasma renin activity of enalapril-treated rats. Propranolol significantly reduced the rise in plasma renin in rats receiving enalapril. None of these findings could be explained by changes in the ratio of active and inactive renin. Water diuresis, without natriuresis and with a decrease in potassium urinary excretion, occurred with the higher dose of enalapril. Enalapril did not potentiate the elevation of PRA in two-kidney one-clip Goldblatt hypertensive rats. In conclusion, enalapril produced renin secretion, which was in part beta-adrenergically mediated.(ABSTRACT TRUNCATED AT 250 WORDS)
Pulsed Power Generation by Solid-State LTD (2014)

A solid-state linear transformer driver stack has been developed to demonstrate pulsed power generation and output pulse shaping. It consists of 30 modules each using 24 power metal–oxide–semiconductor field-effect transistors as switches. The output voltage of the stack is the superposition of the voltage pulse of each module no matter if the modules are switched synchronously or not. In synchronous operation, the output voltages of all modules are added up to reach an output voltage up to <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sim 29$ </tex-math></inline-formula> kV with a maximum output current of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sim 240$ </tex-math></inline-formula> A. The pulsewidth is variable in the range of 50–170 ns. On the other hand, by carrying out separate switching of different modules, the output waveform can be varied by performing pulse shaping. The control signals for pulse shaping experiment are generated using an field-programmable gate array board that allows potentially automatic waveform optimization.
New Atom Probe Tomography Reconstruction Algorithm for Multilayered Samples: Beyond the Hemispherical Constraint (2017)

Accuracy of atom probe tomography measurements is strongly degraded by the presence of phases that have different evaporation fields. In particular, when there are perpendicular interfaces to the tip axis in the specimen, layers thicknesses are systematically biased and the resolution is degraded near the interfaces. Based on an analytical model of field evaporated emitter end-form, a new algorithm dedicated to the 3D reconstruction of multilayered samples was developed. Simulations of field evaporation of bilayer were performed to evaluate the effectiveness of the new algorithm. Compared to the standard state-of-the-art reconstruction methods, the present approach provides much more accurate analyzed volume, and the resolution is clearly improved near the interface. The ability of the algorithm to handle experimental data was also demonstrated. It is shown that the standard algorithm applied to the same data can commit an error on the layers thicknesses up to a factor 2. This new method is not constrained by the classical hemispherical specimen shape assumption.