gebhart/patrepeval huggingface dataset:
On‐chip potential gradient detection with a portable capillary electrophoresis system (2004)

A portable chip-CE system with potential gradient detection (PGD) was developed and applied to the determinations of alkali metals and alkaloids. The separation efficiency appeared to be satisfactory and nonaqueous capillary electrophoresis (NACE) proved to be applicable to PGD or conductivity detection. The power supplies, separation and detection were built on a device of 3 kg in weight. A branch channel near the end of the separation channel was designed to perform PGD and make the application of relatively high field strength possible. The study is the first report on the application of PGD on the microchip platform. The design of the chip-CE system shows several advantages, such as simplicity, miniaturization and wide applicability.
Optimizing the Purification of Biofunctionalized Carbon Nanotubes (2006)

The utilization of single-walled carbon nanotubes (SWNTs) in large quantities for molecular electronics, optoelectronics, biosensors, and medical applications will require SWNTs of the same physical structure, electronic type, and band gap. Since current methods of synthesis produce mixtures of nanotubes with different physical structures and electrical properties, the development of strategies for the postproduction separation of these one-dimensional materials is highly desirable. In this work, we demonstrate a scalable method for separating SWNTs by diameter using density gradient centrifugation. Of particular interest for biosensing applications is the bulk purification of SWNTs through centrifugation of DNA wrapped SWNTs in aqueous density gradients. The dependence of this process on DNA sequence and length has been determined. In addition, strategies for decreasing the purification time are outlined. Overall, this nondestructive and scalable separation strategy is expected to impact a variety of applications for SWNTs where monodisperse structure and properties are essential.
Gyroless Transfer Orbit Sun Acquisition Using Only Wing Current Feedback (2009)

This paper presents a unique and innovative concept of controlling the spacecraft maneuver using only the wing current feedback as its sole closed-loop feedback sensor for attitude control. The control and estimation laws were derived based on fundamental optimization technique. As a result, the spacecraft will maneuver itself to orient the solar panel to its maximum solar exposure spinning attitude. Simulation studies have shown promising result and a US patent is filed underway
An optical vortex transmissometer (2018)

We demonstrate a novel approach for transmissometry that uses an optical vortex for e↵ective discrimination between scattered and ballistic light. Current commercial transmissometers reject unwanted scattered light using a narrow field-of-view (FOV), but this technique fails in multiple scatter environments, or in Mie scattering regimes where large particles create a high probability of scatter near the beam axis. In the optical vortex approach to transmissometry, received light passes through a di↵ractive spiral phase plate. Coherent nonscattered light that passes through the phase plate will create an intensity vortex, while incoherent scattered light will not. The resulting spatial dependence can be exploited to discriminate between the scattered and ballistic light. We present experimental results demonstrating the e↵ectiveness of this approach.
Joint Disentangling and Adaptation for Cross-Domain Person Re-Identification (2020)

Although a significant progress has been witnessed in supervised person re-identification (re-id), it remains challenging to generalize re-id models to new domains due to the huge domain gaps. Recently, there has been a growing interest in using unsupervised domain adaptation to address this scalability issue. Existing methods typically conduct adaptation on the representation space that contains both id-related and id-unrelated factors, thus inevitably undermining the adaptation efficacy of id-related features. In this paper, we seek to improve adaptation by purifying the representation space to be adapted. To this end, we propose a joint learning framework that disentangles id-related/unrelated features and enforces adaptation to work on the id-related feature space exclusively. Our model involves a disentangling module that encodes cross-domain images into a shared appearance space and two separate structure spaces, and an adaptation module that performs adversarial alignment and self-training on the shared appearance space. The two modules are co-designed to be mutually beneficial. Extensive experiments demonstrate that the proposed joint learning framework outperforms the state-of-the-art methods by clear margins.
Growth of Buffer Layers on Si Substrate for High-T<sub>c</sub> Superconducting Thin Films (1991)

We have investigated the crystalline properties and surface morphology of the buffer layers of Y 2 O 3 , ZrO 2 and Y 2 O 3 /ZrO 2 on a Si(100) substrate for a superconducting thin film. The results of RHEED and X-ray diffraction indicate the hetero-epitaxial growth of buffer layers on Si(100) substrates. Epitaxial planes of the buffer layers on the Si(100) surface are (110), (100) and (100)/(100) for Y 2 O 3 , ZrO 2 and Y 2 O 3 /ZrO 2 , respectively. YBa 2 Cu 3 O 7- x thin films have been grown on Si with each buffer layer. The highest critical temperature obtained was 88 K on the Si with the Y 2 O 3 /ZrO 2 buffer layer.
Retrotransposon insertion in <i>SILV</i> is responsible for merle patterning of the domestic dog (2006)

Merle is a pattern of coloring observed in the coat of the domestic dog and is characterized by patches of diluted pigment. This trait is inherited in an autosomal, incompletely dominant fashion. Dogs heterozygous or homozygous for the merle locus exhibit a wide range of auditory and ophthalmologic abnormalities, which are similar to those observed for the human auditory-pigmentation disorder Waardenburg syndrome. Mutations in at least five genes have been identified as causative for Waardenburg syndrome; however, the genetic bases for all cases have not been determined. Linkage disequilibrium was identified for a microsatellite marker with the merle phenotype in the Shetland Sheepdog. The marker is located in a region of CFA10 that exhibits conservation of synteny with HSA12q13. This region of the human genome contains SILV, a gene important in mammalian pigmentation. Therefore, this gene was evaluated as a candidate for merle patterning. A short interspersed element insertion at the boundary of intron 10/exon 11 was found, and this insertion segregates with the merle phenotype in multiple breeds. Another finding was deletions within the oligo(dA)-rich tail of the short interspersed element. Such deletions permit normal pigmentation. These data show that SILV is responsible for merle patterning and is associated with impaired function of the auditory and ophthalmologic systems. Although the mutant phenotype of SILV in the human is unknown, these results make it an intriguing candidate gene for human auditory-pigmentation disorders.
Continuous wearable health monitoring using novel PPG optical sensor and device (2014)

We are presenting a novel photoplethysmographic (PPG) optical sensor and device with ambient optical, electrical and electromagnetic noises cancellation, thus allowing only the useful optical signals to be received by the health monitoring device. We are also disclosing a new processing technique for canceling the ambient noises contributed by optical, electrical and electromagnetic artifacts in the measured PPG signals. Such a device and method allow the enhancement of the performance of the PPG sensors compared to conventional apparatus and methods. The presented sensor and methodology have been integrated into a prototype device for noninvasive, continuous, wearable, remote and mobile monitoring of human vital signs, such as heart rate, oxygen saturation, blood pressure, respiration rate, etc. This small device allows the user to read, store, process and transmit all the measurements made using the PPG optical sensor and the electronic unit to a remote location.
Dose-Dependent and Synergistic Effects of Proteoglycan 4 on Boundary Lubrication at a Human Cornea–Polydimethylsiloxane Biointerface (2011)

PRG4 functions as an effective ocular surface boundary lubricant, both alone in a dose-dependent manner and in combination with HA.
Fiber laser: A new technique for the detection of trace gases (Invited Talk) (2015)

A new technique, based on fiber laser technology for the detection of trace gases, was developed. An erbium-doped fiber was used as the gain medium. The sensitivity of the system was explored based on the length of the gas cell, which was used inside the cavity. The system was capable of detecting gases at sub-ppm concentration levels.
Real time Advisory System for Fuel Economy Improvement in a Hybrid Electric Vehicle (2008)

In this paper, we present an improved version of the Advisory System for Fuel Economy Improvement in a Hybrid Electric Vehicle [11]. We address the competing requirements for improved fuel economy, while maintaining performance that is close to the current driving style and driver behavior. This is done by introducing a multiple-input, multiple-output rule base with a fuzzy reasoning mechanism that decomposes the space of the main factors that affect vehicle fuel economy and performance - instantaneous fuel consumption, acceleration, speed, and accelerator pedal position. This approach allows us to properly assign the boundaries of the desired accelerator pedal position that correspond to each of the specific areas, which are defined by the rules’ antecedents. The system was developed and validated on the Ford (INSERT YEAR and make like SE) HEV Escape vehicle.
A Recombinant La Sota Vaccine Strain Expressing Multiple Epitopes of Infectious Bronchitis Virus (IBV) Protects Specific Pathogen-Free (SPF) Chickens against IBV and NDV Challenges (2019)

Infectious bronchitis (IB) and Newcastle disease (ND) are two major infectious diseases that are a threat to the domestic poultry industry. In this study, we successfully generated a recombinant LaSota candidate vaccine strain, rNDV-IBV-T/B, which expresses a short, synthetic, previously identified IBV S1 multi-epitope cassette using the reverse genetic system. The recombinant virus was propagated in nine-day-old embryonated chicken eggs for 20 passages and genetic stability was confirmed by whole genome DNA sequencing. The recombinant virus had a hemagglutination (HA) titer of 2<sup>10</sup>, mean death time (MDT) of 118 hours, and intracerebral pathogenicity index (ICPI) of 0.05. None of these were significantly different from the parental Newcastle disease virus (NDV) LaSota strain (<i>p</i> > 0.05). Vaccination of white leghorn chickens at one day of age with 10<sup>6</sup> EID<sub>50</sub> rNDV-IBV-T/B provided 90% protection against virulent IBV M41 challenge at three weeks of age, which was significantly higher than the protection of the control group vaccinated with phosphate-buffered saline (PBS) (<i>p</i> < 0.05). The ciliostasis scores of rNDV-IBV-T/B-vaccinated and LaSota-vaccinated groups were 4.2 and 37.6, respectively, which indicated that rNDV-IBV-T/B vaccination reduced the pathogenicity of IBV toward the trachea. Furthermore, real-time RT-PCR assay showed that the rNDV-IBV-T/B vaccination resulted in low levels of viral load (647.80 ± 49.65 RNA copies) in the trachea four days post-challenge, which is significantly lower than groups vaccinated with PBS (8591.25 ± 311.10 RNA copies) or LaSota (7742.60 ± 298.50 RNA copies) (<i>p</i> < 0.05). Meanwhile, the same dose of rNDV-IBV-T/B vaccination provided complete protection against velogenic NDV F48E9 challenge. These results demonstrate that the rNDV-IBV-T/B strain is a promising vaccine candidate to control both IB and ND simultaneously. Furthermore, epitope-based live vector vaccines provide an alternative strategy for the development of cost-effective and, broadly, cross-protective vaccines.
Markovnikov‐Selective Palladium Catalyst for Carbonylation of Alkynes with Heteroarenes (2017)

A new class of palladium catalysts, based on heterocyclic diphosphines, was rationally designed and synthesized. Application of one of these catalysts allows novel Markovnikov-selective carbonylation of non-activated alkynes with heteroarenes to give the corresponding branched α,β-unsaturated ketones in excellent yields (up to 97 %) and regioselectivities (b/l up to 99:1). In addition to heteroarenes, other common nucloephiles (alcohol, phenol, amine, and amide) furnish the desired carbonylation products smoothly in high yields.
Laser testing of MCM-D structures (1999)

Non-invasive techniques for measuring electric field strengths in multichip module substrates can be extremely important in determining ultimate module performance. Certain polymers such as polyimide exhibit an electro-optic response, after appropriate doping and poling, that permits direct measurement of these internal fields with a laser probe. Our work compares different poled polyimides for their efficacy as both an MCM dielectric layer and as an electro-optic material.
1027 Development and Performance Prediction of Water Jet Peening (WJP) : (3) Numerical Simulation on Bubble Collapse Energy (2010)

We developed a numerical method for predicting a distribution of compressive residual stress on a material surface after water jet peeing (WJP). WJP applies the bubble collapse energy of cavitating jet to the change of residual stress from tensile to compressive for preventing the occurrence of stress corrosion cracking. We estimated the impulsive bubble pressure that varied in microseconds by using a numerical simulation with 'bubble flow model'. The bubble collapse energy was evaluated by the cavitation intensity calculated from the bubble pressure. The cavitation intensity was predicted when the cavitating jet was impinged slantingly on cylinders, and was compared with the measured compressive residual stress after WJP. The distribution of the cavitation intensity corresponded qualitatively to that of the compressive residual stress on the cylinder surface.
An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations (2018)

The standard method to quantify the hemagglutinin content of influenza virus vaccines is the single radial immunodiffusion assay. This assay primarily relies on polyclonal antibodies against the head domain of the influenza virus hemagglutinin, which is the main target antigen of influenza virus vaccines. Novel influenza virus vaccine candidates that redirect the immune response towards the evolutionary more conserved hemagglutinin stalk, including chimeric hemagglutinin and headless hemagglutinin constructs, are highly dependent on the structural integrity of the protein to present conformational epitopes for neutralizing antibodies. In this study, we describe a novel enzyme-linked immunosorbent assay that allows quantifying the amount of hemagglutinin with correctly folded stalk domains and which could be further developed into a potency assay for stalk-based influenza virus vaccines.
P‐1.12: 5T2C Hybrid Compensation Circuit for AMOLED Displays (2018)

We introduce a novel pixel circuit for active matrix‐organic light emitting diode (AMOLED) displays. This pixel circuit is a kind of hybrid compensation method with both internal compensation and external compensation, wherein the pixel circuit includes five n‐type thin‐film transistors (TFTs) and two capacitors (5T2C) as well as an organic light‐emitting diode (OLED). In this kind of hybrid compensation, the external compensation extracts the threshold voltage of the driving TFT during the turning on or turning off period of the TV. Once the threshold voltage is extracted, they can be used during the internal compensation procedure. By simulating the pixel circuit using this hybrid compensation method, we confirm that the pixel circuit can compensate the panel stability by internal compensation and the whole panel uniformity by external compensation due to the shift of the threshold voltage of the driving TFT.
Low‐latency Java communication devices on RDMA‐enabled networks (2015)

Summary Providing high‐performance inter‐node communication is a key capability for running high performance computing applications efficiently on parallel architectures. In fact, current systems deployments are aggregating a significant number of cores interconnected via advanced networking hardware with Remote Direct Memory Access (RDMA) mechanisms, that enable zero‐copy and kernel‐bypass features. The use of Java for parallel programming is becoming more promising thanks to some useful characteristics of this language, particularly its built‐in multithreading support, portability, easy‐to‐learn properties, and high productivity, along with the continuous increase in the performance of the Java virtual machine. However, current parallel Java applications generally suffer from inefficient communication middleware, mainly based on protocols with high communication overhead that do not take full advantage of RDMA‐enabled networks. This paper presents efficient low‐level Java communication devices that overcome these constraints by fully exploiting the underlying RDMA hardware, providing low‐latency and high‐bandwidth communications for parallel Java applications. The performance evaluation conducted on representative RDMA networks and parallel systems has shown significant point‐to‐point performance increases compared with previous Java communication middleware, allowing to obtain up to 40% improvement in application‐level performance on 4096 cores of a Cray XE6 supercomputer. Copyright © 2015 John Wiley & Sons, Ltd.
Optical characteristics of triangular microresonator with long evanescent field on the total internal reflection mirror (2011)

We investigated the properties of a triangular microresonator using the total internal reflection (TIR) mirrors with a long evanescent field around the critical angle. For the sensitivity analysis, we have calculated the mirror offset due to the Goos-Hänchen effect and the resonance shift of the triangular resonator with the refractive index change of the outer region in the TIR mirror. The mirror offset is increased up to 0.8 μm for the transverse electric (TE) polarization and 2.0 μm for the transverse magnetic (TM) polarization to the incident angle of 18°. Then, the resonance shift of 417 pm for the TM polarized light and 34 pm for the TE polarized light were observed, respectively, by changing the refractive index of 4×10<sup>-5</sup>. The measured extinction ratio of triangular ring resonator was about 6 dB near 1550 nm, in where the incidence angle of the TIR mirror inside the resonator was 18°.
Translocated duplication of a targeted chromosomal segment enhances gene expression at the duplicated site and results in phenotypic changes in Aspergillus oryzae (2018)

In this study, we performed translocated chromosomal duplications and triplications of a 1.4-Mb targeted region of chromosome 2. Strains containing a duplication of chromosome 2 showed significant increases in protease and amylase activities; these enzymatic activities were further increased in the strain containing a triplication of chromosome 2. This indicates that segmental duplications of chromosomes enhance gene-dosage effects, and that the resulting phenotypes play important phenotypic roles in <i>A. oryzae</i>.
Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters (2016)

Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu<sup>2+</sup> ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu<sup>2+</sup> added, thereby facilitating the detection of the desired concentration range of bilirubin.
Computer-Generated Holographic Stereograms (2009)

We examine one type of holographic stereogram and its implementation on two widely different media. The first medium is photoresist for a conventional computer-generated hologram. The second medium is photo-refractive polymer for re-writable holograms.
Immunoglobulin E Antibodies to Papaya Proteinases and Their Relevance to Chemonucleolysis (1995)

The results suggested that removal of glycyl endopeptidase and caricain from pharmaceutical preparations of chymopapain may help reduce the incidence of allergic reactions during chemonucleolysis.
Abstract 3448: Subtypes of medulloblastoma have distinct developmental origins (2011)

Abstract Medulloblastoma encompasses a collection of clinically and molecularly diverse tumor subtypes that together comprise the most common malignant childhood brain tumor. These tumors are thought to arise within the cerebellum, with approximately 25% originating from granule neuron precursor cells (GNPCs) following aberrant activation of the Sonic Hedgehog pathway (hereafter, SHH-subtype). The pathological processes that drive heterogeneity among the other medulloblastoma subtypes are not known, hindering the development of much needed new therapies. Here, we provide evidence that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT-subtype), arises outside the cerebellum from cells of the lower rhombic lip (LRL). We found that genes marking human WNT-subtype medulloblastomas are more frequently expressed in the LRL and embryonic dorsal brainstem than in the upper rhombic lip (URL) and developing cerebellum. Magnetic resonance imaging (MRI) and intra-operative reports showed that human WNT-subtype tumors infiltrate the dorsal brainstem, while SHH-subtype tumors are located within the cerebellar hemispheres. Activating mutations in Ctnnb1 had little impact on progenitor cell populations in the cerebellum, but caused an aberrant accumulation of proliferating precursor cells within the LRL. These lesions persisted in the dorsal brainstem of all mutant adult mice and in 15% of cases in which Tp53 was concurrently deleted, progressed to form medulloblastomas that modeled faithfully the anatomy and gene expression profiles of human WNT-subtype medulloblastoma. We provide the first evidence that subtypes of medulloblastoma have distinct cellular origins. Our data provide an explanation for the marked molecular and clinical differences between SHH and WNT-subtype medulloblastomas and have profound implications for future research and treatment of this important childhood cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3448. doi:10.1158/1538-7445.AM2011-3448