gebhart/patrepeval huggingface dataset:
Enhancing cisplatin sensitivity in MCF-7 human breast cancer cells by down-regulation of Bcl-2 and cyclin D1 (2006)

MCF-7 human breast cancer cells are relatively resistant to cisplatin treatment compared to other breast cancer cell lines. In order to identify possible targets for sensitizing the breast cancer cells to cisplatin treatment protein expression levels and the phosphorylation status of 27 different signaling proteins were examined. MCF-7 cells expressed high levels of anti-apoptotic Bcl-2 protein relative to more cisplatin sensitive breast cancer cells. After cisplatin treatment a decrease in cyclin D1 was seen in all the breast cancer cells studied. Therefore, Bcl-2 and cyclin D1 were chosen as putative targets for increasing cell death and growth arrest induced by cisplatin, thereby enhancing the drug sensitivity in MCF-7. RNA interference, using Bcl-2- and cyclin D1- siRNAs sensitized MCF-7 cells to cisplatin treatment and by simultaneous knockdown of both Bcl-2 and cyclin D1 further sensitization was seen. This shows the potential of targeting both apoptotic- and cell cycle-regulating pathways to enhance the effect of chemotherapy.
<title>Evaluation of HOE for head-mounted display</title> (1999)

We will discuss the characteristics of the Head Mounted Display (HMD) using Holographic Optical Element (HOE) in this paper. We have already proposed that using the HOE we could realize the see-through HMD, that is to say the binocular stereoscopic display. This time we evaluate the influence on the human vision system regarding the optical characteristics of the HOE. The HMD using HOE we proposed so far is the Maxwellian View which is the direct projection on the human retina. When we see something by Maxwellian View, we don't need the focusing of the crystalline lens (ocular accommodation) because the depth field is extremely wide. Therefore our binocular crystalline lens will focus at the vergence point when the Maxwellian View is used on the binocular retina. And we can solve the dissociation of accommodation and convergence which is the basic problem of the conventional HMD. We have made the prototype of HOE which can provide the Maxwellian View on our retina and we have proved that our HOE could separate the binocular images onto left and right eye. In this report, we will introduce the Maxwellian View will change the ocular accommodation optionally according to the convergence when we see the real objects and the virtual objects at the same time. We proved that the HOE which provided the Maxwellian View could solve the dissociation of accommodation and convergence.
The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy (2013)

Receptors for the Fc portion of IgG (FcγRs) are mandatory for the induction of various IgG-dependent models of autoimmunity, inflammation, anaphylaxis, and cancer immunotherapy. A few FcγRs have the ability to bind monomeric IgG: high-affinity mouse mFcγRI, mFcγRIV, and human hFcγRI. All others bind IgG only when aggregated in complexes or bound to cells or surfaces: low-affinity mouse mFcγRIIB and mFcγRIII and human hFcγRIIA/B/C and hFcγRIIIA/B. Although it has been proposed that high-affinity FcγRs are occupied by circulating IgG, multiple roles for mFcγRI and mFcγRIV have been reported in vivo. However, the potential roles of hFcγRI that is expressed on monocytes, macrophages, and neutrophils have not been reported. In the present study, we therefore investigated the role of hFcγRI in antibody-mediated models of disease and therapy by generating hFcγRI-transgenic mice deficient for multiple endogenous FcRs. hFcγRI was sufficient to trigger autoimmune arthritis and thrombocytopenia, immune complex-induced airway inflammation, and active and passive systemic anaphylaxis. We found monocyte/macrophages to be responsible for thrombocytopenia, neutrophils to be responsible for systemic anaphylaxis, and both cell types to be responsible for arthritis induction. Finally, hFcγRI was capable of mediating antibody-induced immunotherapy of metastatic melanoma. Our results unravel novel capabilities of human FcγRI that confirm the role of high-affinity IgG receptors in vivo.
A Testbed for Experimentation of Innovative Services in the B3G Framework (2005)

UMTS 3G networks are going to be widely deployed commercially, even if in their first releases they will be mainly focused on telephony and multimedia services based on circuit switched technologies. The roll out of the 3GPP IP Multimedia Subsystem (IMS), that can be forecast to happen in the next few years, will introduce mobile users to a new class of multimedia services based on the Internet protocol. The research community is already investigating a possible evolution for the 3G networks based on heterogeneous high-speed access networks allowing new multimedia services and a global coverage (Beyond 3G - B3G). In the present paper we describe a testbed developed by the Co.Ri.TeL. Consortium in the framework of the Presto Project, whose objective is to provide a suitable and common platform, inspired to the IMS ideas, for experimenting a wide variety of B3G SIP-based mobile services. The services experimented on top of the testbed include a multiuser video conferencing architecture, added-value user-defined multimedia services, an audio-video message box and a video-on-demand provisioning infrastructure. The service provisioning mechanisms are all built within a common mobility-management and security framework, providing an approach which is independent from the various possible underlying radio access technologies. In particular, the security capabilities of the developed architecture comprise user and network authentication, authorization to service access and IP-layer signalling cryptography integrated with application-layer mobility.
UNILS: Unconstrained indoors localization scheme based on cooperative smartphones networking with onboard inertial, Bluetooth and GNSS devices (2016)

Location-based services (LBS) are becoming important services on today's smartphones (SPs), tablets and wearable devices. Seamless outdoors-indoors navigation, and especially for accurate indoors localization, is the main demand of LBS users. Onboard WiFi, Bluetooth (BT) or inertial-sensors technologies have been proven to somewhat provide alternative solutions in GNSS-signal-denied areas (i.e. indoors) to define SPs location. However, limited coverage of WiFi access-points (WAPs), pre-installed BT-anchors, constrained of WAPs/BT-anchors physical positions within a building, and limitations of existing localization techniques (in a standalone mode) on SPs are some of the main challenges to designing a spontaneous autonomous positioning solution with reliable accuracy at reasonable cost. This paper proposes an unconstrained indoors localization scheme (UNILS) based on cooperative SPs networking to tackle these challenges. The aim of this new scheme is to fuse multi-technologies measurements on SPs. The scheme uses relative-pseudoranging (based on time-of-arrival `TOA' technique) approach between the connected SPs that are GNSS enabled, especially when the majority of the SPs are outdoors. Then the scheme combines this pseudoranges with uncertainty calculations from onboard dead-reckoning (DR) measurements using Kalman Filter, that can provide seamless and improve location accuracy significantly, especially when deep indoors. This means, in deep indoors, UNILS can utilize only available devices/sensors on SPs, when communication with WAPs or BT-anchors is considered unreliable or unavailable, to offer reasonable cost & good localization performance. Results obtained from actual trials & simulations (using OPNET) of this scheme (based on Android-SPs network implementations for various indoors scenarios) show that around 3-meters accuracy can be achieved when locating SPs at various deep indoors situations.
Heterogeneous Catalysis of CO<sub>2</sub> Conversion to Methanol on Copper Surfaces (2014)

Combined experimental and theoretical approaches resulted in a better understanding of the hydrogenation of CO2 to methanol on copper-based catalysts. These results highlight the important role of the reducible oxide promoter for CO2 activation.
Fast algorithm for computing isogenies between elliptic curves (2009)

The SEA algorithm is used widely in computing the order of elliptic curve,and the computation of isogenies between elliptic curves plays an important part in the algorithm. We surveyed algorithms for computing isogenies between elliptic curves defined over a field of characteristic either 0 or a large prime. Then we introduced a new algorithm that computes an isogeny of degree t. This algorithm is based on continued fraction. The complexity of the proposed algorithm is O(t).
RF energy harvester design with autonomously adaptive impedance matching network based on auxiliary charge-pump rectifier (2011)

This paper presents an implementation of a radio frequency wave energy harvester with the capability of self-adjusting the matching network to adapt to changing load conditions. An auxiliary charge-pump is designed to supply the power for the supplemental control unit. The design is implemented in a standard 0.13-μm CMOS process. The results show that the power transfer efficiency with using the proposed design can achieve a level of over 70% independent of the load conditions.
Surface wave enhanced broadband planar antenna for wireless applications (2001)

This letter explores the development of a new class of broadband antenna in which TE/sub 0/ surface-wave is used as the primary source of free space radiation. We demonstrate that antennas based on this concept can be designed to operate over a broad bandwidth, be extremely compact, and can be easily integrated with MIC and MMIC technology. Measurement of return loss and radiation pattern characteristics of the antenna described in this letter indicate a 47% operating bandwidth, covering a large part of the frequency spectrum assigned for U.S. as well as European high-speed wireless local area network (WLAN) applications, making it ideal for integration with WLAN modules.
The Classless Static Route Option for Dynamic Host Configuration Protocol (DHCP) version 4 (2002)

This document defines a new Dynamic Host Configuration Protocol (DHCP) option which is passed from the DHCP Server to the DHCP Client to configure a list of static routes in the client.The network destinations in these routes are classless -each routing table entry includes a subnet mask.
Dietary quality among men and women in 187 countries in 1990 and 2010: a systematic assessment (2015)

The Bill & Melinda Gates Foundation and Medical Research Council.
Efficient Secure Auction Protocols Based on the Boneh-Goh-Nissim Encryption (2012)

This paper presents efficient secure auction protocols for first price auction and second price auction. Previous auction protocols are based on a generally secure multi-party protocol called mix-and-match protocol based on plaintext equality tests. However, the time complexity of the plaintext equality tests is large, although the mix-and-match protocol can securely calculate any logical circuits. The proposed protocols reduce the number of times the plaintext equality tests is used by replacing them with the Boneh-Goh-Nissim encryption, which enables calculation of 2-DNF of encrypted data.
[Effect of mesenchymal stem cells transplantation on the apoptosis after rat myocardial infarction]. (2004)

Mesenchymal stem cells transplantation can promote the expression of bcl-2 mRNA in the infarct area and relieve apoptosis after rat myocardial infarction.
Fundamental bounds on the operation of Fano nonlinear isolators (2018)

Nonlinear isolators have attracted significant attention for their ability to break reciprocity and provide isolation without the need of an external bias. A popular approach for the design of such devices is based on Fano resonators, which, due to their sharp frequency response, can lead to very large isolation for moderate input intensities. Here, we show that, independent of their specific implementation, these devices are subject to fundamental bounds on the transmission coefficient in the forward direction versus their quality factor, input power, and nonreciprocal intensity range. Our analysis quantifies a general tradeoff between forward transmission and these metrics, stemming directly from time-reversal symmetry, and that unitary transmission is only possible for vanishing nonreciprocity. Our results also shed light on the operation of resonant nonlinear isolators, reveal their fundamental limitations, and provide indications on how it is possible to design nonlinear isolators with optimal performance.
GSK2374697, a Novel Albumin-Binding Domain Antibody (AlbudAb), Extends Systemic Exposure of Exendin-4: First Study in Humans—PK/PD and Safety (2014)

GSK2374697 is a genetically engineered fusion protein of a human domain antibody to exendin-4. This molecule binds with a high affinity to human serum albumin, creating a long-duration glucagon-like peptide-1 (GLP-1) receptor agonist. This study is the first evaluation of the albumin-binding domain antibody (AlbudAb) drug delivery platform in humans. The aim of this randomized clinical study was to determine the pharmacokinetics, pharmacodynamics, safety, and tolerability of GSK2374697. The pharmacokinetic profile was prolonged, with estimated half-lives ranging from 6 to 10 days. Postprandial glucose and insulin were reduced, and gastric emptying was delayed in healthy subjects, confirming anticipated GLP-1 receptor agonist pharmacology. The safety and tolerability were as expected for a potent GLP-1 agonist. Gradual titration of doses greatly improved tolerability. Rapid tolerance to nausea was observed. Study results support further investigation in type 2 diabetes and for weight loss.
Explosion pressure design criteria for new seals in U.S. coal mines. (2007)

This report provides a sound scientific and engineering justification to recommend a three-tiered explosion pressure design criterion for new seals. The recommendations contained herein apply to new seal design and construction in U.S. coal mines.
Fabrication of zinc sulphide hierarchical hollow spheres with photocatalytic property by a mild organic acid-assisted route (2010)

Large quantities of zinc sulphide hierarchical hollow spheres were successfully obtained by a mild organic acid-assisted route using zinc chloride anhydrous and thiourea as precursors. Malonic acid played a key role as a structure-directing agent in driving such hierarchical hollow spheres structures. Certain amounts of malonic acid are necessary in formation of zinc sulphide hierarchical hollow spheres. The photocatalytic properties of as-synthesised zinc sulphide hierarchical hollow spheres have been studied, which shows an excellent photocatalytic activity for the degradation of rhodamine B under ultra-violet.
Butadiene Polymerization Catalyzed by Lanthanide Metallocene−Alkylaluminum Complexes with Cocatalysts:  Metal-Dependent Control of 1,4-Cis/Trans Stereoselectivity and Molecular Weight (2006)

A series of bimetallic complexes composed of lanthanide metallocene and trimethylaluminum, Cp*2Ln[(μ-Me)AlMe2(μ-Me)]2LnCp*2 (Cp* = η5-C5Me5, Ln = Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Tm, Yb, Lu), were prepared, and the ability to catalyze polymerization of butadiene in the presence of cocatalysts, AlR3 (R = Me, iBu) and [Ph3C][B(C6F5)4], was studied as a function of the 11 different lanthanide metal species and the kind of alkylaluminum in the cocatalyst. Both catalytic activity and microstructure of polybutadiene depended strongly on the kind of lanthanide metal and the trialkylaluminum. The Gd complex in combination with AliBu3/[Ph3C][B(C6F5)4] was extremely active and gave perfectly 1,4-cis regulated polybutadiene at −40 °C. In contrast, the Ce complex with almost similar cocatalysts, AlMe3/[Ph3C][B(C6F5)4], yielded polybutadiene having a very high content of 1,4-trans microstructure (1,4-trans selectivity = 93.8%). With the Al/Ln ratio was 3−5, the polymerization systems, in which the alkylaluminum worked as an activator, showed somewhat living-like nature; the Mn of the resulting polybutadiene increased in proportion to monomer consumption, while the molecular weight distribution stayed narrow throughout the reactions. In the presence of a large amount of monomer, molecular weight of polybutadiene was conveniently controlled by additional excess alkylaluminum, which functioned as a chain transfer agent.
Object classification based on a geometric grammar with a range camera (2009)

This paper proposes an object classification framework based on a geometric grammar aimed for mobile robotic applications. The paper first discusses the geometric grammar as a compact representation form for object categories with primitive parts as its constituent elements. The paper then discusses the object classification implemented as parsing of primitive parts. In particular, two approaches are discussed that constrain the search space in order to render the parsing of the primitive parts practical. The two approaches are experimentally verified, first, for a generic object category of chair applied to real range images acquired with a range camera mounted on a mobile robot and, second, for multiple generic object categories applied to synthetic range images. The experimental results show the practicability of the framework.
Liquid crystals. 6. Mesomorphic phenols and primary amines. p-Phenylene dibenzoates with terminal hydroxy and amino groups (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid crystals. 6. Mesomorphic phenols and primary amines. p-Phenylene dibenzoates with terminal hydroxy and amino groupsD. C. Schroeder and J. P. SchroederCite this: J. Org. Chem. 1976, 41, 15, 2566–2571Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/jo00877a013https://doi.org/10.1021/jo00877a013research-articleACS PublicationsRequest reuse permissionsArticle Views250Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On IEEE 802.11: Wireless Lan Technology (2013)

Network technologies are traditionally based on wireline solutions. But the introduction of the IEEE 802.11 standards have made a huge impact on the market such that laptops, PCs, printers, cellphones, and VoIP phones, MP3 players in our homes, in offices and even in public areas have incorporated the wireless LAN technology. Wireless broadband technologies nowadays provide unlimited broadband access to users which were previously offered only to wireline users. In this paper, we review and summarize one of the emerging wireless broadband technology i.e. IEEE 802.11,which is a set of physical layer standard for implementing wireless local area network computer communication in the 2.4,3.6,5 and 60GHz frequency band. They fix technology issues or add functionality which is expected to be required by future applications. Though some of the earlier versions of these technologies are obsolete (such as HiperLAN) now but still we have included them in this review for the sake of completeness.
Macronutrient balance and lifespan (2009)

Dietary restriction (DR) without malnutrition is widely regarded to be a universal mechanism for prolonging lifespan. It is generally believed that the benefits of DR arise from eating fewer calories (termed caloric restriction, CR). Here we argue that, rather than calories, the key determinant of the relationship between diet and longevity is the balance of protein to non-protein energy ingested. This ratio affects not only lifespan, but also total energy intake, metabolism, immunity and the likelihood of developing obesity and associated metabolic disorders. Among various possible mechanisms linking macronutrient balance to lifespan, the nexus between the TOR and AMPK signaling pathways is emerging as a central coordinator.
Sudden Death in Patients With Cardiac Implantable Electronic Devices (2015)

Systematic interrogation and autopsy of sudden deaths in one city identified concerns about CIED function that might otherwise not have been observed. Current passive surveillance efforts may underestimate device malfunction. These methods can provide unbiased data regarding causes of sudden death in individuals with CIEDs and improve surveillance for CIED problems.
Comparison of Three Clinical Trial Treatments for Autism Spectrum Disorder Through Multivariate Analysis of Changes in Metabolic Profiles and Adaptive Behavior (2018)

Several studies associate autism spectrum disorder (ASD) pathophysiology with metabolic abnormalities related to DNA methylation and intracellular redox homeostasis. In this regard, three completed clinical trials are reexamined in this work: treatment with (i) methylcobalamin (MeCbl) in combination with low-dose folinic acid (LDFA), (ii) tetrahydrobiopterin, and (iii) high-dose folinic acid (HDFA) for counteracting abnormalities in the folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathways and also for improving ASD-related symptoms and behaviors. Although effects of treatment on individual metabolites and behavioral measures have previously been investigated, this study is the first to consider the effect of interventions on a set of metabolites of the FOCM/TS pathways and to correlate FOCM/TS metabolic changes with behavioral improvements across several studies. To do so, this work uses data from one case-control study and the three clinical trials to develop multivariate models for considering these aspects of treatment. Fisher discriminant analysis (FDA) is first used to establish a model for distinguishing individuals with ASD from typically developing (TD) controls, which is subsequently evaluated on the three treatment data sets, along with one data set for a placebo, to characterize the shift of FOCM/TS metabolism toward that of the TD population. Treatment with MeCbl plus LDFA and, separately, treatment with tetrahydrobiopterin significantly shifted the metabolites toward the values of the control group. Contrary to this, treatment with HDFA had a lesser, though still noticeable, effect whilst the placebo group showed marginal, but not insignificant, variations in metabolites. A second analysis is then performed with non-linear kernel partial least squares (KPLS) regression to predict changes in adaptive behavior, quantified by the Vineland Adaptive Behavior Composite, from changes in FOCM/TS biochemical measurements provided by treatment. Incorporating the 74 samples receiving any treatment, including placebo, into the regression analysis yields an <i>R</i> <sup>2</sup> of 0.471 after cross-validation when using changes in six metabolic measurements as predictors. These results are suggestive of an ability to effectively improve pathway-wide FOCM/TS metabolic and behavioral abnormalities in ASD with clinical treatment.