gebhart/patrepeval huggingface dataset:
MEMS Louvers for Thermal Control (1998)

Mechanical louvers have frequently been used for spacecraft and instrument thermal control purposes. These devices typically consist of parallel or radial vanes, which can be opened or closed to vary the effective emissivity of the underlying surface. This project demonstrates the feasibility of using Micro-Electromechanical Systems (MEMS) technology to miniaturize louvers for such purposes. This concept offers the possibility of substituting the smaller, lighter weight, more rugged, and less costly MEMS devices for such mechanical louvers. In effect, a smart skin that self adjusts in response to environmental influences could be developed composed of arrays of thousands of miniaturized louvers. Several orders of magnitude size, weight, and volume decreases are potentially achieved using micro-electromechanical techniques. The use of this technology offers substantial benefits in spacecraft/instrument design, integration and testing, and flight operations. It will be particularly beneficial for the emerging smaller spacecraft and instruments of the future. In addition, this MEMS thermal louver technology can form the basis for related spacecraft instrument applications. The specific goal of this effort was to develop a preliminary MEMS device capable of modulating the effective emissivity of radiators on spacecraft. The concept pursued uses hinged panels, or louvers, in a manner such that heat emitted from the radiators is a function of louver angle. An electrostatic comb drive or other such actuator can control the louver position. The initial design calls for the louvers to be gold coated while the underlying surface is of high emissivity. Since, the base MEMS material, silicon, is transparent in the InfraRed (IR) spectrum, the device has a minimum emissivity when closed and a maximum emissivity when open. An initial set of polysilicon louver devices was designed at the Johns Hopkins Applied Physics Laboratory in conjunction with the Thermal Engineering Branch at NASA's Goddard Space Flight Center.
Robust Self-Supervised Extrinsic Self-Calibration (2023)

Autonomous vehicles and robots need to operate over a wide variety of scenarios in order to complete tasks efficiently and safely. Multi-camera self-supervised monocular depth estimation from videos is a promising way to reason about the environment, as it generates metrically scaled geometric predictions from visual data without requiring additional sensors. However, most works assume well-calibrated extrinsics to fully leverage this multi-camera setup, even though accurate and efficient calibration is still a challenging problem. In this work, we introduce a novel method for extrinsic calibration that builds upon the principles of self-supervised monocular depth and ego-motion learning. Our proposed curriculum learning strategy uses monocular depth and pose estimators with velocity supervision to estimate extrinsics, and then jointly learns extrinsic calibration along with depth and pose for a set of overlapping cameras rigidly attached to a moving vehicle. Experiments on a benchmark multi-camera dataset (DDAD) demonstrate that our method enables self-calibration in various scenes robustly and efficiently compared to a traditional vision-based pose estimation pipeline. Furthermore, we demonstrate the benefits of extrinsics self-calibration as a way to improve depth prediction via joint optimization.
Sequence influence of nonidentical InGaAsP quantum wells on broadband characteristics of semiconductor optical amplifiers–superluminescent diodes (2001)

Extremely broadband emission is obtained from semiconductor optical amplifiers-superluminescent diodes with nonidentical quantum wells made of InGaAsP/InP materials. The well sequence is experimentally shown to have a significant influence on the emission spectra. With the three In(0.67) Ga(0.33) As(0.72) P(0.28) quantum wells near the n -cladding layer and the two In(0.53) Ga(0.47) As quantum wells near the p -cladding layer, all bounded by In(0.86) Ga(0.14) As(0.3)P(0.7) barriers, the emission spectrum could cover from less than 1.3 to nearly 1.55 microm, and the FWHM could be near 300 nm.
VVC In-Loop Filters (2021)

This paper presents an overview of the technologies for in-loop processing and filtering in the Versatile Video Coding (VVC) standard. These processes comprise luma mapping with chroma scaling, deblocking filter, sample adaptive offset, adaptive loop filter and cross-component adaptive loop filter. They are qualified as “in-loop” because they are applied inside the encoding and decoding loops, before storing the pictures in the decoded picture buffer. The filters are complementary and address different purposes. Luma mapping with chroma scaling aims at adaptively modifying the coded samples distribution for improved coding efficiency. The deblocking filter aims at reducing blocking discontinuities. Sample adaptive offset mostly aims at reducing artifacts resulting from the quantization of transform coefficients. Adaptive loop filter and cross-component adaptive loop filter are adaptive filters enabling to enhance the reconstructed signal, using for instance Wiener-filter encoding approaches. The paper provides an overview of the in-loop filtering process and a detailed description of the filtering algorithms. Objective compression efficiency results are provided for each filter, with indication of cumulative coding gains. Subjective benefits are illustrated. Implementation issues considered during the design of the VVC in-loop filters are also discussed.
Mammalian Cell DNA Replication (1997)

The precise mechanisms involved in the regulation of the mammalian cell DNA-synthesizing machinery are poorly understood. In vitro DNA replication systems, in particular the employment of the simian virus 40 (SV40)-based cell-free DNA replication system, has identified several mammalian enzymes and proteins required for DNA synthesis. Although these proteins have been identified as playing a role in DNA replication, their functional organization allowing for the efficient replication of DNA has not been well defined. This review describes the proteins that have currently been defined as having a role in mammalian DNA replication and their proposed mechanisms of action. How these proteins may organize themselves to form multiprotein complexes, or larger DNA replication factories, allowing for efficient chromosomal DNA synthesis is discussed. In addition, the cell cycle regulation of mammalian DNA synthesis and the current status concerning mammalian DNA replication origins is described.
Prediagnostic Appearance of Thrombospondin Type-1 Domain 7A Autoantibodies in Membranous Nephropathy (2022)

Key Points The entire extracellular domain of thrombospondin type-1 domain 7A (THSD7A) in the luciferase immunoprecipitation system immunoassay was required to detect autoantibodies with high sensitivity in membranous nephropathy (MN). In THSD7A-seropositive MN patients, changes in antibody levels precede changes in clinical status. Seropositive THSD7A antibodies were detected in some patients with MN considered to be secondary to autoimmunity or cancer. Background Pathogenic autoantibodies against thrombospondin type-1 domain 7A (THSD7A) are present in approximately 3% of patients with membranous nephropathy (MN). Compared with PLA2R antibodies, less is known about THSD7A autoantibodies (ABs) because of the relative rarity and the lack of a commercially available quantitative immunoassay. Methods In this study, we describe the development and validation of a highly quantitative luciferase immunoprecipitation system (LIPS) assay for detecting THSD7A ABs and used it to study dominant THSD7A epitopes, disease associations, and monitoring disease activity. The Department of Defense Serum Repository (DODSR) was then used to analyze THSD7A AB in 371 longitudinal serum samples collected before clinical diagnosis of MN from 110 PLA2R-negative MN subjects. Results LIPS analysis demonstrated that a near full-length THSD7A (amino acids 1–1656) detected robust autoantibody levels in all known seropositive MN patients with 100% sensitivity and specificity compared with ELISA and/or Western blotting. Most of the THSD7A-seropositive subjects in our pilot cohort had evidence of coexisting autoimmunity or cancer. Moreover, three THSD7A-seropositive patients undergoing immunosuppressive therapy showed longitudinal autoantibody levels that tracked clinical status. Additional epitope analysis of two smaller protein THSD7A fragments spanning amino acids 1-416 and 1-671 demonstrated lower sensitivity of 32% and 44%, respectively. In the DODSR cohort, THSD7A seropositivity was detected in 4.5% of PLA2R-negative MN patients. In one primary and in one secondary MN-associated with cancer, THSD7A ABs were detectable <1 month before biopsy-proven diagnosis. In addition, three patients with lupus membranous nephropathy had detectable THSD7A ABs years before hypoalbuminemia and biopsy-proven diagnosis. Conclusions Although further studies are needed to explore the significance of THSD7A ABs in lupus membranous nephropathy, this study describes a novel, highly sensitive LIPS immunoassay for detecting THSD7A ABs and adds to the existing literature on THSD7A-associated MN. Clinical Trial registry name and registration number: NCT00977977; registration date: September 16, 2009.
Using Orbital Angular Momentum Modes for Optical Transmission (2014)

We review recent progress on optical transmission using orbital angular momentum (OAM) modes. Free-space OAM transmissions with a spectral efficiency of 95.7 bit/s/Hz and an aggregate capacity of 100.8 Tbit/s and 1.1-km fiber OAM transmission with an aggregate capacity of 1.6 Tbit/s are demonstrated. Grooming OAM networking functionalities and future challenges are also discussed.
Dual-color imaging of cytosolic and mitochondrial zinc ions in live tissues with two-photon fluorescent probes (2014)

We report two-photon probes for Zn(2+) ions that can simultaneously detect cytosolic and mitochondrial Zn(2+) ions in live cells and living tissues at 115 mm depth by dual-color TPM imaging with minimum interference from other biologically relevant species.
Photonic crystal fibres in the market (2011)

Photonic crystal fibres (PCFs) emerged as a research topic in the mid 1990'ies [1]. Today, 15 years later, these fibres are increasing deployed in various commercial markets. Here, we will address three of these markets; medical imaging, materials processing and sensors. We will describe how the PCFs provide radical improvements and illustrate the strong diversity in the evolution of PCFs to serve these different markets.
Detecting Phycocynanin-Pigmented Microbes in Reflected Light (2008)

A recently invented method of measuring concentrations of phycocynanin-pigmented algae and bacteria in water is based on measurement of the spectrum of reflected sunlight. When present in sufficiently high concentrations, phycocynanin-pigmented microorganisms can be hazardous to the health of humans who use, and of animals that depend on, an affected body of water. The present method is intended to satisfy a need for a rapid, convenient means of detecting hazardous concentrations of phycocynanin-pigmented microorganisms. Rapid detection will speed up the issuance of public health warnings and performance of corrective actions. The method involves the measurement of light reflected from a body of water in at least two, but preferably five wavelength bands. In one version of the method, the five wavelength bands are bands 1, 3, 4, 5, and 7 of the Thematic Mapper (TM) multispectral imaging instrument aboard the Landsat-7 satellite (see table). In principle, other wavelength bands indicative of phycocynanin could be used alternatively or in addition to these five. Moreover, although the method was originally intended specifically for processing Landsat- 7 TM data, it is equally applicable to processing of data from other satellite-borne instruments or from airborne, hand-held, buoy-mounted, tower-mounted, or otherwise mounted instruments that measure radiances of light reflected from water in the wavelength bands of interest.
Finding Causal Mechanistic Drug-Drug Interactions from Observational Data. (2020)

Many adverse drug reactions (ADRs) are caused by drug-drug interactions (DDIs), meaning they arise from concurrent use of multiple medications. Detecting DDIs using observational data has at least three major challenges: (1) The number of potential DDIs is astronomical; (2) Associations between drugs and ADRs may not be causal due to observed or unobserved confounding; and (3) Frequently co-prescribed drug pairs that each independently cause an ADR do not necessarily causally interact, where causal interaction means that at least some patients would only experience the ADR if they take both drugs. We address (1) through data mining algorithms pre-filtering potential interactions, and (2) and (3) by fitting causal interaction models adjusting for observed confounders and conducting sensitivity analyses for unobserved confounding. We rank candidate DDIs robust to unobserved confounding more likely to be real. Our rigorous approach produces far fewer false positives than past applications that ignored (2) and (3).
Tetramer‐visualized gluten‐specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge (2014)

Quantification of gut-homing, gluten-specific TEM in peripheral blood, visualized with human leukocyte antigen (HLA) -tetramers, may be used to distinguish CD patients from healthy individuals. Easy access to gluten-reactive blood T cells from diseased and healthy individuals may lead to new insights on the disease-driving CD4+ T cells in CD.
6H-SiC Homoepitaxial Growth and Optical Property of Boron- and Nitrogen-Doped Donor-Acceptor Pair (DAP) Emission of 1º-Off Substrate by Closed-Space Sublimation Method (2006)

We demonstrate high-speed and high-quality 6H-SiC homoepitaxial growth on a 1°-off c-plane SiC substrate by a closed-space sublimation method. By optimizing the size of single-crystal source materials in the growth system, a high-quality 6H-SiC epilayer with an X-ray diffraction rocking curve (0006) full-width at the half maximum (FWHM) of 38 arcsec was obtained. We also carried out doping of nitrogen and boron during the growth of the SiC epilayer. A strong donor-acceptor pair (DAP) emission at a peak wavelength of 570 nm under excitation by a 395 nm nitride-based light-emitting diode (LED) was observed. The 6H-SiC with DAP emission is promising for use as a phosphor in a nitride-based LED, because high-quality nitride layers can be grown on the SiC substrates with small off-oriented angles.
Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells (1994)

Unusual activity of the CD44 locus in neoplasia and malignancy is confirmed, and techniques for the analysis of such activity can enable non-invasive investigation of patients for primary or recurrent bladder cancer or for other tumours that shed neoplastic cells into body fluids.
CuO Quantum Dots Decorated TiO<sub>2</sub> Nanocomposite Photocatalyst for Stable Hydrogen Generation (2017)

An efficient and stable CuO-TiO2 nanocomposite photocatalyst was synthesized by using the simple molten-salt method. Characterization by HR-TEM confirmed the existence of both TiO2 and CuO in the nanocomposite, revealing hexagonal TiO2 nanoparticles (NPs) with average particles size of 23.8 nm. CuO QDs decorated on the TiO2 surface were in the range of 2.2 to 4.6 nm. Photocatalytic experiments for hydrogen (H2) production were carried out under an LED (λ = 365 nm) lamp and natural solar light. The effect of Cu-loading in CuO-TiO2 NCs and synthesis time were studied. The optimized CuO-TiO2 NCs abbreviated as CuT-4 and CuT-3 showed 27.7- and 9.0-fold superior rate of H2 production compared to pristine TiO2 NPs under LED and solar irradiation, respectively. At optimal conditions, CuO-TiO2 NCs demonstrated good photostability for H2 evolution during 75 h illumination under LED light. The experimental results confirmed the cocatalytic role of CuO for improved H2 generation by a minimized recombination of excitons.
Characterization of high-efficiency silicon solar cells (1985)

Preliminary results on silicon solar cells of improved performance recently have been described. The present paper describes the results of a more detailed optical and electrical characterization of these devices. The high performance of the cells is shown to be due to a high optical efficiency and near ideal junction characteristics combined with low parasitic resistance losses.
<i>In situ</i> TEM observation of rebonding on fractured silicon carbide (2018)

Silicon carbide (SiC) is widely used in harsh environments and under extreme conditions, including at high-power, high-temperature, high-current, high-voltage and high-frequency. The rebonding and self-matching of stack faults (SFs) is highly desirable to avoid catastrophic failure for SiC devices, especially for specific applications in the aerospace and nuclear power industries. In this study, a novel approach was developed using an eyebrow hair to pick up and transfer nanowires (NWs), in order to obtain in situ transmission electron microscope (TEM) images of the rebonding and self-matching of SFs at atomic resolution. During rebonding and healing, the electron beam was shut off. Rebonding on the fractured surfaces of monocrystalline and amorphous SiC NWs was observed by in situ TEM at room temperature. The fracture strength was 1.7 GPa after crack-healing, restoring 12.9% of that of a single crystal NW. Partial recrystallization along the <111> orientation and the self-matching of SFs are responsible for the rebonding of the monocrystalline NW. In comparison, the fracture strengths were 6.7 and 5.5 GPa for the first and second rebonding, respectively recovering 67% and 55% of that of an amorphous NW. Atomic diffusion contributed enormously to the rebonding on fractured surfaces of an amorphous NW, resulting in a healed surface consisting of an amorphous phase and crystallites. This rebonding function provides new insight into the fabrication of high-performance SiC devices for the aerospace, optoelectronic and semiconductor industries.
Towards an Optimized Culture Medium for the Generation of Mouse Induced Pluripotent Stem Cells (2010)

Generation of induced pluripotent stem cells from somatic cells using defined factors has potential relevant applications in regenerative medicine and biology. However, this promising technology remains inefficient and time consuming. We have devised a serum free culture medium termed iSF1 that facilitates the generation of mouse induced pluripotent stem cells. This optimization of the culture medium is sensitive to the presence of Myc in the reprogramming factors. Moreover, we could reprogram meningeal cells using only two factors Oct4/Klf4. Therefore, iSF1 represents a basal medium that may be used for mechanistic studies and testing new reprogramming approaches.
Antiwear Performance and Mechanism of an Oil-Miscible Ionic Liquid as a Lubricant Additive (2012)

An ionic liquid (IL) trihexyltetradecylphosphonium bis(2-ethylhexyl) phosphate has been investigated as a potential antiwear lubricant additive. Unlike most other ILs that have very low solubility in nonpolar fluids, this IL is fully miscible with various hydrocarbon oils. In addition, it is thermally stable up to 347 °C, showed no corrosive attack to cast iron in an ambient environment, and has excellent wettability on solid surfaces (e.g., contact angle on cast iron <8°). Most importantly, this phosphonium-based IL has demonstrated effective antiscuffing and antiwear characteristics when blended with lubricating oils. For example, a 5 wt % addition into a synthetic base oil eliminated the scuffing failure experienced in neat oil and, as a result, reduced the friction coefficient by 60% and the wear rate by 3 orders of magnitude. A synergistic effect on wear protection was observed with the current antiwear additive when added into a fully formulated engine oil. Nanostructure examination and composition analysis revealed a tribo-boundary film and subsurface plastic deformation zone for the metallic surface lubricated by the IL-containing lubricants. This protective boundary film is believed to be responsible for the IL's antiscuffing and antiwear functionality.
Design of a nasal support for a cleft palate appliance (2009)

Cleft lip and palate is the most common facial malformation occurring in infants. Associated with cleft lip are nasal deformities that are not aesthetically pleasing. Creating a nasal support for a current cleft palate appliance is important in pre-surgically correcting nasal deformations and may present an airway obstruction. The aim of this project is to therefore create a nasal support for a cleft palate appliance. Utilizing two design alternatives the appliance will be verified in order to prove the safety and efficacy of the appliance.
A cocktail of humanized anti–pertussis toxin antibodies limits disease in murine and baboon models of whooping cough (2015)

Despite widespread vaccination, pertussis rates are rising in industrialized countries and remain high worldwide. With no specific therapeutics to treat disease, pertussis continues to cause considerable infant morbidity and mortality. The pertussis toxin is a major contributor to disease, responsible for local and systemic effects including leukocytosis and immunosuppression. We humanized two murine monoclonal antibodies that neutralize pertussis toxin and expressed them as human immunoglobulin G1 molecules with no loss of affinity or in vitro neutralization activity. When administered prophylactically to mice as a binary cocktail, antibody treatment completely mitigated the Bordetella pertussis-induced rise in white blood cell counts and decreased bacterial colonization. When administered therapeutically to baboons, antibody-treated, but not untreated control animals, experienced a blunted rise in white blood cell counts and accelerated bacterial clearance rates. These preliminary findings support further investigation into the use of these antibodies to treat human neonatal pertussis in conjunction with antibiotics and supportive care.
Role of dendritic cell metabolic reprogramming in tumor immune evasion (2020)

The dendritic cell (DC) is recognized as a vital mediator of anti-tumor immunity. More recent studies have also demonstrated the important role of DCs in the generation of effective responses to checkpoint inhibitor immunotherapy. Metabolic programming of DCs dictates their functionality and can determine which DCs become immunostimulatory versus those that develop a tolerized phenotype capable of actively suppressing effector T-cell responses to cancers. As a result, there is great interest in understanding what mechanisms have evolved in cancers to alter these metabolic pathways, thereby allowing for their continued progression and metastasis. The therapeutic strategies developed to reverse these processes of DC tolerization in the tumor microenvironment represent promising candidates for future testing in combination immunotherapy clinical trials.
Effect of Di-t-Butyl Peroxide on the Lean Operating Limit of a Spark-Ignition Engine (1982)

Abstract A study was conducted to determine whether the addition of di-t-butyl peroxide to unleaded gasoline would extend the lean operating limit of a spark-ignition engine. Tests were conducted with a single-cylinder, Cooperative Fuel Research engine. In these tests, the lean misfire limit equivalence ratio was extended by 6 and 10 percent with blends of 1 and 5 volume percent, respectively, of di-t-butyl peroxide and unleaded gasoline, compared to the value obtained with only unleaded-gasoline. It is hypothesized that the improved lean combustion was caused by the dissociation of di-t-butyl peroxide to tertiary butoxy radicals, which in turn reacted with the unleaded gasoline thus increasing the fuel oxidation rate.