gebhart/patrepeval huggingface dataset:
Differential expression of filamin A and its clinical significance in breast cancer (2013)

Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, <i>in vitro</i> studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathological data, in order to provide insightful <i>ex vivo</i> data. A total of 96 breast cancer and distant normal breast tissues and 20 benign tumor tissue specimens were subjected to immunohistochemistry or reverse transcription polymerase chain reaction (RT-PCR) analysis of FLNa expression. Clinicopathological data were collected to analyze the association with FLNa expression. The FLNa protein was overexpressed in breast cancer tissues compared with distant normal mammary gland and benign breast tissues. The FLNa protein was expressed in 63.5% of breast cancer, with positive rates of 36, 66.7 and 84.6%, respectively, in stage I, II and III breast cancer patients (P<0.05). Overexpression of the FLNa protein was associated with advanced stage, lymph node metastasis, vascular or neural invasion, menstruation state and other risk stratifications for breast cancer. The overexpression of FLNa in breast cancer was validated by RT-PCR, indicating transcriptional regulation of FLNa overexpression in breast cancer. FLNa mRNA and protein were overexpressed in breast cancer tissues, which was associated with advanced stage, lymph node metastasis and vascular or neural invasion of breast cancer, suggesting that FLNa contributes to breast cancer development and progression.
Unorthodox C,O Binding Mode of Me<sub>2</sub>BINOL in Pt(II) Complexes <i>J. Am. Chem. Soc.</i> <b>1998</b>, <i>120</i>, 11002−11003 (1999)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionUnorthodox C,O Binding Mode of Me2BINOL in Pt(II) Complexes J. Am. Chem. Soc.1998, 120, 11002−11003Nicole M. Brunkan, Peter S. White, and Michel R. GagnéCite this: J. Am. Chem. Soc. 1999, 121, 4, 894Publication Date (Web):January 15, 1999Publication History Published online15 January 1999Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/ja9855390https://doi.org/10.1021/ja9855390correctionACS PublicationsCopyright © 1999 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views276Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (9 KB) Get e-Alertsclose Get e-Alerts
An Elegant Solution: An Alternative Ultra-Wideband Transceiver Based on Stepped-Frequency Continuous-Wave Operation and Compressive Sensing (2016)

For more than 50 years, since early work beginning in 1960 [1], ultra-wideband (UWB) technology has been developed to analytically verify the transient behavior of a class of transverse electromagnetic mode microwave networks. The U.S. Federal Communications Commission has defined UWB as operating with a minimum fractional bandwidth of 20% or with a minimum -10-dB bandwidth of 500 MHz [2].
Projector-Based Location Discovery and Tracking (2007)

While a number of projects within the computer graphics, computer vision, and human-computer interaction community have explored the powerful ability for projected light to create illusions that can reshape our perception and interaction with surfaces in the environment, very few of these systems have had success in terms of commercial and consumer adoption. Often these systems require expert knowledge to perform system setup and calibration between the projected images and the physical surfaces to make these illusions effective. In this thesis work, I present a technique for inherently adding object location discovery and tracking capabilities to commercial projectors. This is accomplished by introducing light sensors into the projection area and then spatially encoding the image area using a series of structured light patterns. This delivers a unique pattern of light to every pixel in the projector’s screen space directly encoding the location data using the projector itself. I present three evolutionary prototype systems of increasing capability and demonstrate the applications enabled and simplified during each stage of development. By unifying the image projection and location tracking technology into a single device I can greatly simplify the implementation of previous systems and enable interaction capabilities which are difficult or impossible using alternative approaches.
Silica Decomposition Using a Transferred Arc Process (1999)

A novel process for silica decomposition consisting of transferring a thermal arc directly to a silica anode was investigated. The effects of current (150−250 A), plasma gas flow rate (10−20 L/min of Ar), and plasma gas composition (0−2.8% H2) on the rate of decomposition were examined. The decomposition rate ranged from 0.09 to 1.8 g/min and was determined to be heat-transfer-limited, with decomposition occurring below the arc root where the anode surface attained its boiling point. The decomposition rate was independent of plasma gas flow rate, suggesting that convective heat transfer was reduced significantly by the counterflow of decomposition products (SiO(g) and O2) from the surface. Increasing the current increased the decomposition rate because heat input to the anode because of electron flow and arc radiation increased. Adding H2 to the plasma gas increased the decomposition rate because of an increase in radiative heat transfer to the anode, a reduction in the theoretical energy requirement for decomposition, and a consumption of O2 which lowered the silica boiling point. The fumed silica produced had properties typical of commercial fumed silica products.
Interactive visualization of coregistered tomographic images (1995)

The need to superimpose coregistered tomographic images of a body organ obtained using different modalities presents a changeling visualization problem in biomedical imaging. Because of the usual complexity of the information represented, the diverse characteristics of each image and the independent nature of each modality, a single optimal way of portraying a combined image may not exist. A more realistic approach may be to provide several tools that the user can easily apply to interactively determine the clearest representation in each case. Such visuals must allow information from one image to be conveyed without significantly compromising the information content of the complimentary image. A description of some of the techniques that we have employed to simultaneously view functional PET images of the brain together with correlated structural images provided by MRI or CT is presented, the algorithms that define these methods are described and their effectiveness is discussed.
Learned Manipulation at Unconstrained Contacts Does Not Transfer across Hands (2014)

Recent studies about sensorimotor control of the human hand have focused on how dexterous manipulation is learned and generalized. Here we address this question by testing the extent to which learned manipulation can be transferred when the contralateral hand is used and/or object orientation is reversed. We asked subjects to use a precision grip to lift a grip device with an asymmetrical mass distribution while minimizing object roll during lifting by generating a compensatory torque. Subjects were allowed to grasp anywhere on the object's vertical surfaces, and were therefore able to modulate both digit positions and forces. After every block of eight trials performed in one manipulation context (i.e., using the right hand and at a given object orientation), subjects had to lift the same object in the second context for one trial (transfer trial). Context changes were made by asking subjects to switch the hand used to lift the object and/or rotate the object 180° about a vertical axis. Therefore, three transfer conditions, hand switch (HS), object rotation (OR), and both hand switch and object rotation (HS+OR), were tested and compared with hand matched control groups who did not experience context changes. We found that subjects in all transfer conditions adapted digit positions across multiple transfer trials similar to the learning of control groups, regardless of different changes of contexts. Moreover, subjects in both HS and HS+OR group also adapted digit forces similar to the control group, suggesting independent learning of the left hand. In contrast, the OR group showed significant negative transfer of the compensatory torque due to an inability to adapt digit forces. Our results indicate that internal representations of dexterous manipulation tasks may be primarily built through the hand used for learning and cannot be transferred across hands.
Blood pressure control after acute stroke. (1996)

A clinical trial is proposed to establish whether it is better to maintain pre-existing antihypertensive therapy or to discontinue this temporarily.
A one-step low temperature processing route for organolead halide perovskite solar cells (2013)

Organolead trihalide perovskite solar cells based upon the co-deposition of a combined Al2O3-perovskite layer at T < 110 °C are presented. We report an average PCE = 7.2% on a non-sintered Al2O3 scaffold in devices that have been manufactured from a perovskite precursor containing 5 wt% Al2O3 nanoparticles.
Comparison of hydrogeological characteristics between the Sanjiang Plain and the Amur River Basin (2014)

Sanjiang Plain-Amur River Basin aquifer is the aquifer shared by China and Russia, which is of great significance to water sources management for both countries, acting as a focused area by China and Russia. In this paper, the hydrogeological characteristics of the Sanjiang Plain-Amur River Basin is studied, aiming at understanding the differences as well as similarities of aquifer classification, chemical characteristics of groundwater, quantity of groundwater and groundwater evaluation methods of two countries, which will lay a solid foundation to further holistic study of the trans-boundary aquifer in the Sanjiang Plain-Amur River Basin.
The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function (1992)

Morphine-6-glucuronide is a metabolite of morphine that binds to the opioid receptor and is analgesic in animals and humans. Although accumulation of morphine-6-glucuronide in patients with renal insufficiency has been implicated in morphine toxicity, the contribution of the metabolite to morphine analgesia in patients with normal renal function has not been established. To evaluate this contribution, we repeatedly sampled blood and assessed effects during and after a loading infusion with morphine (mean duration, 168 minutes) in 14 patients with chronic pain, all of whom had normal serum creatinine levels. Plasma concentrations of morphine and morphine-6-glucuronide were assayed by use of high performance liquid chromatography with electrochemical detection. Patients were divided into three groups on the basis of the molar concentration ratio of morphine-6-glucuronide:morphine from the start of the infusion until 240 minutes later: Group 1 (n = 5) had a mean ratio greater than or equal to 0.7:1; group 2 (n = 4) had a mean ratio less than 0.7:1 but greater than or equal to 0.4:1; and group 3 (n = 5) had a mean ratio less than 0.4:1. Time-effect plots revealed that average and peak relief were greater in group 1 than group 2 and greater in group 2 than group 3. For all patients, mean morphine-6-glucuronide:morphine ratio throughout the study was significantly correlated with mean pain relief (r = 0.611, p less than 0.02). These data suggest that morphine-6-glucuronide contributes to morphine analgesia in patients with normal renal function. The role of the metabolite should be considered when morphine is used clinically.
Variable structure model reference adaptive control systems (1984)

Model reference adaptive controllers, when only input and output measurements are available, are designed using the theory of variable structure systems. State variable filters are used in order to obtain differentiator-free controllers. The proposed design allows the error transient to be prescribed in advance. The drawbacks deriving from the typical high-frequency chattering of the control signal during the sliding motion can be partially eliminated by means of a little modification of the adaptation law that does not cause the error signal to deteriorate considerably.
Lanthanide Clusters with Chalcogen Encapsulated Ln: NIR Emission from Nanoscale NdSe<sub><i>x</i></sub> (2010)

Ln(SePh)(3) (Ln = Ce, Pr, Nd) reacts with elemental Se in the presence of Na ions to give (py)(16)Ln(17)NaSe(18)(SePh)(16), a spherical cluster with a 1 nm diameter. All three rare-earth metals form isostructural products. The molecular structure contains a central Ln ion surrounded by eight five-coordinate Se(2-) that are then surrounded by a group of 16 Ln that define the cluster surface, with additional μ(3) and μ(5) Se(2-), μ(3) and μ(4) SePh(-), and pyridine donors saturating the vacant coordination sites of the surface Ln, and a Na ion coordinating to selenolates, a selenido, and pyridine ligands. NIR emission studies of the Nd compound reveal that this material has a 35% quantum efficiency, with four transitions from the excited state (4)F(3/2) ion to (4)I(9/2), (4)I(11/2), (4)I(13/2), and (4)I(15/2) states clearly evident. The presence of Na(+) is key to the formation of these larger clusters, where reactions using identical concentrations of Nd(SePh)(3) and Se with either Li or K led only to the isolation of (py)(8)Nd(8)Se(6)(SePh)(12).
Fabrication of skeletal muscle constructs by topographic activation of cell alignment (2008)

Skeletal muscle fiber construction for tissue-engineered grafts requires assembly of unidirectionally aligned juxtaposed myotubes. To construct such a tissue, a polymer microchip with linearly aligned microgrooves was fabricated that could direct myoblast adaptation under stringent conditions. The closely spaced microgrooves fabricated by a modified replica molding process guided linear cellular alignment. Examination of the myoblasts by immunofluorescence microscopy demonstrated that the microgrooves with subcellular widths and appropriate height-to-width ratios were required for practically complete linear alignment of myoblasts. The topology-dependent cell alignment encouraged differentiation of myoblasts into multinucleate, myosin heavy chain positive myotubes. The monolayer of myotubes formed on the microstructured chips allowed attachment, growth and differentiation of subsequent layers of linearly arranged myoblasts, parallel to the primary monolayer of myotubes. The consequent deposition of additional myoblasts on the previous layer of myotubes resulted in three-dimensional multi-layered structures of myotubes, typical of differentiated skeletal muscle tissue. The findings demonstrate that the on-chip device holds promise for providing an efficient means for guided muscle tissue construction.
Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: A systematic review and meta‐analysis of randomized controlled trials (2012)

Hyaluronic acid (HA) is a polysaccharide common to most species and is found in many sites in the human body, including the skin and soft tissue. A systematic review of the literature and meta-analysis was performed to identify randomized controlled trials, evaluating the use of HA derivatives in healing burns, epithelial surgical, and chronic wounds. Nine studies were identified, which met the search criteria and clinical endpoints of complete healing and percent wound size reduction when using HA vs. either an active or passive comparator. It was found in the vast majority of randomized controlled trials (eight of nine) that HA derivatives significantly improved the healing of wounds vs. traditional therapies or placebo (either via complete healing or a significant reduction in wound size) occurring from burns, venous insufficiency, diabetes, neuropathic insufficiency, and surgical removal of the epithelial layer (for tattoo removal). In the other remaining trial, one formulation of HA was compared with another, with the higher concentration showing improved application characteristics. Further, it was found in a meta-analysis in subsets of patients with diabetic foot ulcers (neuropathic) that HA derivatives healed these types of wounds significantly faster than standard of care. These studies in aggregate show that HA derivatives accelerate the healing process in burns, epithelial surgical wounds, and chronic wounds.
Harmonic analysis and resynthesis of Sliding-Tile Puzzle heuristics (2017)

Combinatorial optimization problems such as the Travelling Salesman Problem, Quadratic Assignment Problem and Sliding-Tile Puzzle have structure that can be described algebraically and exploited to improve search quality. In particular, heuristic functions for these problems can be described in terms of symmetric groups. By employing techniques from the emerging field of algebraic machine learning, we investigate the harmonic decomposition of popular sliding-tile puzzle heuristics via the extension of the Fourier Transform to noncommutative groups. The Fourier-space representation for these heuristics can then be manipulated by multiplication with a real-valued weight vector. By performing such a reweighting and then taking the inverse transform, we obtain a `filtered' version of the original heuristic. Taking the 8-puzzle as a case study, we demonstrate that heuristic accuracy is related to harmonic spectral density and further that the heuristic functions given by the Hamming and Manhattan distance metrics on puzzle state can be transformed into significantly better heuristics by performing a search in the weight space.
Nf1-DEFICIENT MICE DISPLAY SOCIAL LEARNING DEFICITS THAT ARE RESCUED BY THE DELETION OF PAK1 GENE (2011)

Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder that affects roughly 1 in 3500 individuals. In addition to physical features (e.g., neurofibromas), developmental disorders are also common that can affect cognition, learning, attention and social function. The NF1 gene encodes neurofibromin, a GTPase activating protein (GAP)-like protein that negatively regulates Ras GTPase activation. Mutation at the NF1 locus increases the output of MAPK and PI3K signal transduction from the cellular membrane to the nucleus. Similar to humans, Nf1+/- mice show spatial learning abnormalities that are potentially correlated with increases in GABA-mediated inhibition and deficits in long-term potentiation in the hippocampus. Here, we demonstrate for the first time that Nf1+/- mice exhibit a selective loss of long-term social learning / memory and increased GABAergic inhibition in the basolateral amygdala, a critical brain region for regulating social behaviors. Next, utilizing a genetic intercross, we show that the co-deletion of p21-activated kinase type 1 (Pak1-/-), which positively regulates MAPK activation, restores Nf1+/--dependent MAPK hyperactivation in neurons cultured from the frontal cortex. We found that the co-deletion of Pak1 in Nf1+/- mice (Nf1+/- / Pak1-/-) also restores the deficits in long-term social learning / memory seen in Nf1+/- mice and normalizes the increases in GABA-mediated inhibition in the BLA, as compared to Nf1+/- mice. Together, these findings establish a role for Nf1 and Pak1 genes in the regulation of social learning in Nf1-deficient mice. Furthermore, proteomic studies identify dysregulation of F-actin and microtubule dynamics in the prefrontal cortex, and implicate proteins associated with vesicular release as well as neurite formation and outgrowth (e.g., LSAMP, STXBP1, DREB). In the BLA, disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) was identified, and ADAM22 may play a role in the regulation of AMPA receptors. Finally, due to the increased co-occurrence of NF1 and autism, these findings may also have important implications for the pathology and treatment of NF1-related social deficits and some forms of autism.
Silicon hydrides and molybdenum(0) catalyst: a novel approach for conjugate reduction of .alpha.,.beta.-unsaturated carbonyl compounds (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilicon hydrides and molybdenum(0) catalyst: a novel approach for conjugate reduction of .alpha.,.beta.-unsaturated carbonyl compoundsEhud Keinan and Daniel PerezCite this: J. Org. Chem. 1987, 52, 12, 2576–2580Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/jo00388a042https://doi.org/10.1021/jo00388a042research-articleACS PublicationsRequest reuse permissionsArticle Views1150Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Self‐assembled and Patterned Fe and Fe<sub>3</sub>O<sub>4</sub> Dots on III—V Semiconductors (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.