gebhart/patrepeval huggingface dataset:
Protective Efficacy of Rhesus Adenovirus COVID-19 Vaccines against Mouse-Adapted SARS-CoV-2 (2021)

The global COVID-19 pandemic has sparked intense interest in the rapid development of vaccines as well as animal models to evaluate vaccine candidates and to define immune correlates of protection. We recently reported a mouse-adapted SARS-CoV-2 virus strain (MA10) with the potential to infect wild-type laboratory mice, driving high levels of viral replication in respiratory tract tissues as well as severe clinical and respiratory symptoms, aspects of COVID-19 disease in humans that are important to capture in model systems. We evaluated the immunogenicity and protective efficacy of novel rhesus adenovirus serotype 52 (RhAd52) vaccines against MA10 challenge in mice. Baseline seroprevalence is lower for rhesus adenovirus vectors than for human or chimpanzee adenovirus vectors, making these vectors attractive candidates for vaccine development. We observed that RhAd52 vaccines elicited robust binding and neutralizing antibody titers, which inversely correlated with viral replication after challenge. These data support the development of RhAd52 vaccines and the use of the MA10 challenge virus to screen novel vaccine candidates and to study the immunologic mechanisms that underscore protection from SARS-CoV-2 challenge in wild-type mice. <b>IMPORTANCE</b> We have developed a series of SARS-CoV-2 vaccines using rhesus adenovirus serotype 52 (RhAd52) vectors, which exhibit a lower seroprevalence than human and chimpanzee vectors, supporting their development as novel vaccine vectors or as an alternative adenovirus (Ad) vector for boosting. We sought to test these vaccines using a recently reported mouse-adapted SARS-CoV-2 (MA10) virus to (i) evaluate the protective efficacy of RhAd52 vaccines and (ii) further characterize this mouse-adapted challenge model and probe immune correlates of protection. We demonstrate that RhAd52 vaccines elicit robust SARS-CoV-2-specific antibody responses and protect against clinical disease and viral replication in the lungs. Further, binding and neutralizing antibody titers correlated with protective efficacy. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
The automated extraction of requirements from UML models (2004)

We have observed that often there is a disconnect between a UML model and the requirements of the modeled processes. This gap tends to widen as models become more complex and the extraction of detailed requirements becomes more difficult. The process by which detailed requirements are extracted from a model is fairly straightforward. Not only can the technique be used to extract requirements, but, interestingly enough, the same information that is extracted can be used to generate the task list part of a project plan, as the concrete use cases identify the pieces of software that need to be implemented. The use case model is basically an acyclic directed graph, with dependencies as vertices and use cases as nodes. In order for the extraction process to work, the use case model needs to be built following certain guidelines. For example: No dependency cycles and model continuity (e.g. a single continuous directed graph).
Mureidomycins A-D, novel peptidylnucleoside antibiotics with spheroplast forming activity. I. Taxonomy, fermentation, isolation and physico-chemical properties. (1989)

A strain of actinomycetes identified as Streptomyces flavidovirens produced new antibiotics, mureidomycins (MRD's) A approximately D, specifically active against Pseudomonas aeruginosa. They were isolated from the culture filtrate by successive column chromatographies such as Amberlite XAD-2 and CG-50, Whatman DE-52 and Toyopearl HW-40. They were amphoteric white powders and soluble in methanol and water. Their molecular weights and molecular formulae in parentheses were 840 (C38H48N8O12S), 842 (C38H50N12S), 897 (C40H51N9O13S) and 899 (C40H53N9O13S), respectively. m-Tyrosine and two unknown substances were detected by amino acid analyses as their common constituents. MRD's A and C contained uracil but MRD's B and D dihydrouracil instead of uracil.
Discovery and Synthesis of a New Series of High-Potency L-Aspartyl-D-.alpha.-aminoalkanoyl-(S)-.alpha.-alkylbenzylamide Sweeteners (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiscovery and Synthesis of a New Series of High-Potency L-Aspartyl-D-.alpha.-aminoalkanoyl-(S)-.alpha.-alkylbenzylamide SweetenersJames G. Sweeny, Lihong L. D'Angelo, Edith A. Ricks, and Guillermo A. IacobucciCite this: J. Agric. Food Chem. 1995, 43, 8, 1969–1976Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/jf00056a003https://doi.org/10.1021/jf00056a003research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Desulfurization and conversion of coal under supercritical conditions (1985)

The supercritical desulfurization process is based on the observation that, in the presence of alcohol under temperature and pressure conditions above the critical point of the alcohol being used for the extraction/reaction process, organic sulfur is selectively removed from the coal matrix. Over 50% reduction in total sulfur concentration was attained in batch reactor experiments when a high organic sulfur content coal (organic sulfur comprising 73% of the total sulfur) was processed using pretreatment with a potassium hydroxide solution, followed by a supercritical extraction with methyl alcohol. A continuous reactor process development unit has been constructed at the Coal Technology Laboratory and preliminary test results and unit design are discussed. The combination of a physical coal cleaning process for removal of pyritic sulfur, followed by supercritical extraction with alcohol to reduce organic sulfur, would combine the advantages of both processes.
Accurate markerless jaw tracking for facial performance capture (2019)

We present the first method to accurately track the invisible jaw based solely on the visible skin surface, without the need for any markers or augmentation of the actor. As such, the method can readily be integrated with off-the-shelf facial performance capture systems. The core idea is to learn a non-linear mapping from the skin deformation to the underlying jaw motion on a dataset where ground-truth jaw poses have been acquired, and then to retarget the mapping to new subjects. Solving for the jaw pose plays a central role in visual effects pipelines, since accurate jaw motion is required when retargeting to fantasy characters and for physical simulation. Currently, this task is performed mostly manually to achieve the desired level of accuracy, and the presented method has the potential to fully automate this labour intense and error prone process.
Beneficial Impact of Interspecies Chimeric Renal Organoids Against a Xenogeneic Immune Response (2022)

Interspecies chimeric renal organoids may differentiate into mature renal tissues of each renal progenitor cell lineage. Furthermore, they may reduce transplant rejection compared with xenograft organoids.
Time-frequency-code slicing: efficiently allocating the communications spectrum to multirate users (1997)

The time-frequency-code slicing technique allows multiple users with different data-rate requirements access to a communications resource in a manner that is cost effective over a wide range of access rates. For Instance, with a time-frequency slicing (TFS) approach, users are assigned different portions of the frequency spectrum (e.g., on a slot-by-slot basis), granting them access to a fraction of the shared resource that is commensurate with their needs and their own end equipment. Users with high-data-rate requirements can "grab all the band-width" when no one else needs it. Also, by efficiently packing the time-frequency space, better system utilization is attained. For the specific case of TFS, we compute the reduction in blocking probability achieved under the constraint of a single transmitter/receiver per user. As an example, consider the case of 70% traffic load with ten frequency bands and 15 time slots per frame. Using the traditional allocation scheme in which users can be assigned only a single-frequency band per time slot, there is a 10% blocking probability for new connections that request 14 "time-frequency slices". The TFS technique reduces this blocking probability to well below 0.01%.
Drifting reduction in progressive fine granularity scalable video coding (2001)

This paper investigates the drifting problem in Progressive Fine Granularity Scalable (PFGS) video coding, which arises from the fact that high quality references are used to predict the enhancement layer. Due to the unique property of the PFGS scheme, this paper first analyzes the occurrence and propagation of the drifting errors in details. As a result, an iterative model is established to simulate the drifting errors at the encoder. With the proposed drifting model, a decision-making mechanism can help the PFGS scheme to choose the coding mode of each macroblock in the enhancement layer. The experimental results show that the PFGS scheme incorporating the proposed technique can effectively reduce the drifting errors at low bit rates. Meanwhile, the PFGS scheme also improves the coding efficiency up to 1.8dB compared with the FGS scheme at moderate or high bit rates.
P HYSICIAN I NTERPRETATION AND Q UANTITATIVE M EASURES OF E LECTROCARDIOGRAPHIC V ENTRICULAR F IBRILLATION W AVEFORM (2001)

With only fair agreement on the threshold of fine VF and asystole, defibrillation decisions are largely subjective and caregiver-specific. These data suggest that quantitative measures of the VF waveform could augment the current standard of subjective classification of VF by emergency care providers.
Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response (2014)

Cellular proteins that fail to fold properly result in inactive or disfunctional proteins that can have toxic functions. The unfolded protein response (UPR) is a two-tiered cellular mechanism initiated by eukaryotic cells that have accumulated misfolded proteins within the endoplasmic reticulum (ER). An adaptive pathway facilitates the clearance of the undesired proteins; however, if overwhelmed, cells trigger apoptosis by upregulating transcription factors such as C/EBP-homologous protein (CHOP). A high throughput screen was performed directed at identifying compounds that selectively upregulate the apoptotic CHOP pathway while avoiding adaptive signaling cascades, resulting in a sulfonamidebenzamide chemotype that was optimized. These efforts produced a potent and selective CHOP inducer (AC<sub>50</sub> = 0.8 μM; XBP1 > 80 μM), which was efficacious in both mouse embryonic fibroblast cells and a human oral squamous cell cancer cell line, and demonstrated antiproliferative effects for multiple cancer cell lines in the NCI-60 panel.
Peritoneal Dialysis Solutions for the 21st Century (1998)

Existing peritoneal dialysis (PD) solutions were formulated for the maintenance of fluid and electrolyte balance, correction of metabolic acidosis, and the removal of metabolic waste products. Solutions currently in development are designed to improve biocompatibility by neutralizing pH and reducing glucose degradation products. PD solutions developed for the 21st century will address major clinical needs related to the maintenance of adequate nutrition, improvement of cardiovascular comorbidity, preservation of peritoneal membrane function, and adequacy of dialysis. Nutrineal is the first example of a PD solution to address such a clinical need. Another example is a low sodium solution to improve sodium balance thereby reducing the incidence of hypertension and the need for antihypertensive medication. New solutions under investigation will employ additives to protect the peritoneal membrane during peritonitis and chronic PD and to optimize PD therapy via improvements in ultrafiltration and solute clearances. Examples include the use of antioxidants to reduce oxidative damage during peritonitis and the use of glycosaminoglycans or other additives to enhance ultrafiltration. Future concepts include remodeling of the peritoneum, for example, the use of mesothelial gene therapy to introduce metabolic and anabolic machinery to remove or perpetually recycle metabolic wastes. The 21st century promises to be an exciting and fruitful time for the investigation and development of new products for the improvement of PD therapy.
A low-complexity relaying protocols for incremental DF relay systems with co-channel interference (2013)

In this paper, we evaluate the interference effect on the performance of incremental decode-and-forward (DF) relay systems with a low-complexity relaying protocols and interference at the relays and destination. These protocols are based on the switch-and-examine diversity combining (SEC) and switch-and-examine diversity combining with post-examining selection (SECps) techniques. Based on the relaying criterion, the first checked relay whose second hop signal-to-noise ratio (SNR) satisfies a predetermined switching threshold is asked to forward the source message to destination only if the direct link is in outage. Closed-form expression is derived for the end-to-end (e2e) outage probability assuming Rayleigh fading channels. Also, the system performance is studied at high SNR regime for the two relaying protocols where the diversity order and coding gain are derived and analyzed. We assume that maximal-ratio combining (MRC) is used at the destination to combine the signal through the relay with that on the direct link. Monte-Carlo simulations are provided to validate the achieved analytical results. Findings illustrate that despite the presence of interference, the system still achieves performance gain and that the outage probability decreases when the number of relays increases, especially, in the range of SNR values that are comparable to switching threshold. Also, results show the effectiveness of the SEC and SECps relaying protocols in reducing the system complexity compared to the existing protocols as the opportunistic relaying.
How to Tickle Spins with a Fourier Transform NMR Spectrometer (2012)

In the long bygone days of continuous-wave nuclear magnetic resonance (NMR) spectroscopy, a selected transition within a multiplet of a high-resolution spectrum could be irradiated by a highly selective continuous-wave (CW) radio-frequency (rf) field with a very weak amplitude ω(2)/(2π)≤J. This causes splittings of connected transitions, allowing one to map the connectivities of all transitions within the energy-level diagram of the spin system. Such "tickling" experiments stimulated the invention of two-dimensional spectroscopy, but seem to have been forgotten for nearly 50 years. We show that tickling can readily be achieved in homonuclear systems with Fourier transform spectrometers by applying short pulses in the intervals between the sampling points. Extensions to heteronuclear systems are even more straightforward since they can be carried out using very weak CW rf fields.
Segmented Binary Control of Shape Memory Alloy Actuators — Feedforward Servo Control (2004)

A new approach to the design and control of shape memory alloy (SMA) actuators, called Segmented Binary Control (SBC), is extended from previous work. The transient response of SBC is examined and is discovered to be inadequate in real time servo control because of significant latency times. A dramatic improvement is shown using a feedforward method in which a predetermined path is known and appropriate actions are calculated beforehand. In addition, this feedforward servo control of SMA is accomplished with only internal local feedback loops and no global feedback of position.
Integrated Petrophysical Evaluation of Shale Gas Reservoirs (2008)

Abstract Gas shales are economically viable hydrocarbon prospects that have proven to be successful in North America. Unlike conventional hydrocarbon prospects, gas shales serve as the source, seal, and the reservoir rock. Generating commercial production from these unique lithofacies requires stimulation through extensive hydraulic fracturing. The absence of an accurate petrophysical model for these unconventional plays makes the prediction of economic productivity and fracturing success risky. This paper presents an integrated approach to petrophysical evaluation of shale gas reservoirs, specifically, the Barnett Shale from the Fort Worth basin is used as an example. The approach makes use of different formation evaluation data, including density, neutron, acoustic, nuclear magnetic resonance, and geochemical logging data. This combination of logging measurements is used to provide lithology, stratigraphy and mineralogy. It also differentiates source rock intervals, classifies depositional facies by their petrophysical and geomechanical properties, and quantifies total organic carbon. The analysis is also employed to locate optimal completion intervals, zones preferable for horizontal sections, and intervals of possible fracture propagation attenuation. Resistivity image analysis complements the approach with the identification of natural and drilling induced fractures. We compare results from three different wells to show the effectiveness of the method for shale gas characterization. The methodology presented provides a means to understand the geomechanical and petrophysical properties of the Barnett Shale. This knowledge can be used to design a selective completion strategy that has the potential to reduce fracturing expenses and optimize well productivity. Though developed specifically for the Barnett Shale, the underlying ideas are applicable to other thermogenic shale gas plays in North America.
Hard‐clipping joint transform correlator using a microchannel spatial light modulator (1988)

Abstract A programmable real‐time optical joint transform correlator that generates sharper autocorrelation peaks is presented. A microchannel spatial light modulator is utilized as the threshold hard‐clipping square‐law device. A liquid crystal television is used to display the input target and reference image. The basic principle of the system and a preliminary experimental result are given.
High speed, low dose, intelligent X-ray cargo inspection (2015)

The security market requirements for high throughput rail cargo radiography inspection systems include better than 5 mm line pair imaging resolution, penetration beyond 400 mm steel equivalent, scan speeds of up to 60 km/h, material discrimination (four groups of Z) in 100 % of cargo at speeds reaching 45 km/h, low dose and small radiation exclusioi zone. In order to achieve these requirements, which cannot be met by conventional dual energy radiography systems, a team lead by RadiaBeam Technologies, LLC (RBT) has initiated a research into new radiography methods and imaging detector materials with the goal of developing an Adaptive Railroad Cargo Inspection System (ARCIS). The ARCIS technical concept relies on linac-based, adaptive, ramped energy source of packets of short X-ray pulses sampled by a new type of fast X-ray detectors with rapid hardware processing for intelligent linac control, and advanced radiography image processing and material discrimination analysis. The following ARCIS key enabling technologies overcome the limitations of the conventional dual energy interlaced cargo inspection systems: Multi-energy material discrimination in a single scan line provided by packets of short pulses from an X-ray source with end-point energy ramp up (> 1 MHz rate of energy switching); Real-time intelligent setting of packet's maximum energy depend on X-ray attenuation in cargo; Fast Scintillation-Cherenkov detectors with reduced sensitivity to scatter radiation; Detector readout with Silicon Photomultiplier (SiPM) provides time-resolving of short X-ray pulses; Self-control adaptive dynamic adjustment of SiPM responsivity in detector channel for increased dynamic range.
Functional fabrication of recombinant human collagen–phosphorylcholine hydrogels for regenerative medicine applications (2014)

The implant-host interface is a critical element in guiding tissue or organ regeneration. We previously developed hydrogels comprising interpenetrating networks of recombinant human collagen type III and 2-methacryloyloxyethyl phosphorylcholine (RHCIII-MPC) as substitutes for the corneal extracellular matrix that promote endogenous regeneration of corneal tissue. To render them functional for clinical application, we have now optimized their composition and thereby enhanced their mechanical properties. We have demonstrated that such optimized RHCIII-MPC hydrogels are suitable for precision femtosecond laser cutting to produce complementing implants and host surgical beds for subsequent tissue welding. This avoids the tissue damage and inflammation associated with manual surgical techniques, thereby leading to more efficient healing. Although we previously demonstrated in clinical testing that RHCIII-based implants stimulated cornea regeneration in patients, the rate of epithelial cell coverage of the implants needs improvement, e.g. modification of the implant surface. We now show that our 500μm thick RHCIII-MPC constructs comprising over 85% water are suitable for microcontact printing with fibronectin. The resulting fibronectin micropatterns promote cell adhesion, unlike the bare RHCIII-MPC hydrogel. Interestingly, a pattern of 30μm wide fibronectin stripes enhanced cell attachment and showed the highest mitotic rates, an effect that potentially can be utilized for faster integration of the implant. We have therefore shown that laboratory-produced mimics of naturally occurring collagen and phospholipids can be fabricated into robust hydrogels that can be laser profiled and patterned to enhance their potential function as artificial substitutes of donor human corneas.
Design of a memory-scalable wavelet-based image codec (2002)

The goal of this research is to develop a high performance image codec to be implemented in a digital signal processor (DSP). This DSP chip has only a small amount of internal memory that is fast enough to keep up with the clock cycle of CPU. A new wavelet image codec called the scalable binary description (S-BiD) codec is proposed to achieve this goal. S-BiD, consists of an external wavelet transform and the block-based quantization scheme. The external wavelet algorithm uses a DWT-specific pre-fetching technique to reduce the impact of large access delay of a bulk storage device. Wavelet coefficients are quantized into a set of interleaved multiple bit-streams that describe the three layers in the quantization hierarchy, i.e. blocks, subbands and coefficients, respectively. The codec can generate good compressed images even when the size of the cache memory is less than 4 Kbyte. With a cache memory of 16 Kbyte, its PSNR performance is comparable with all other codecs while its coding time is the shortest. If more resources are available, its performance will be even better.