gebhart/patrepeval huggingface dataset:
Selective Reactive Ion Etching of Indium‐Tin Oxide in a Hydrocarbon Gas Mixture (1991)

A new method for the reactive ion etching of a transparent conducting indium‐tin oxide (ITO) film has been investigated. With a gas mixture consisting of acetone, argon, and oxygen, high etch rate selectivities of ITO to a number of underlying materials were achieved. A useful variation on the etch process employs hydrogen chloride in a first etch step followed by the acetone‐based etch. Acetone is a source of reactive organic radicals in the plasma discharge that etch ITO films by forming volatile organometallic compounds. Selective chemical vapor deposition of carbon films on surfaces that do not etch can occur using this chemistry, but with sufficient oxygen in the plasma this is eliminated. An analysis of the plasma etch chemistry based on plasma emission spectroscopy is also presented.
A New Architecture for Optical Burst Switched Networks Based on a Common Control Channel (2006)

This paper presents a new architecture for Optical Burst Switched networks featuring a novel common control channel (C3-OBS). The control plane of the network is shared and distributed, enabling better network resource planning at each node. A model of the C3-OBS OXC Node is proposed, the manageable bandwidth of a C3-OBS network is assessed and the common control channel load is evaluated. This architecture implements the "Well Informed Node" concept as a method to schedule network resource utilization. The scope and application of C3-OBS networks is studied and the implementation of Domains as a solution to its geographical extension is proposed.
Hypoallergenic Mutants of the Timothy Grass Pollen Allergen Phl p 5 Generated by Proline Mutations (2012)

The hypoallergenic Phl p 5 variant MPV.7 combines multiple proline deletions with a substitution of proline 211 to leucine and meets basic demands for a pharmaceutical application. MPV.7 is a promising candidate for grass pollen immunotherapy with a cocktail of recombinant hypoallergens.
Amplifying ribbon extensometer for measuring film and fabric strain (1975)

Variations of a low-cost amplifying linear threshold extensometer are presented in detail for high or low strain applications. Derivations of scale relationships and extraction forces are included with experimental correlations and analyses given on performance, attachment problems, gain selection, gage and base material compatibility, and zero setting techniques. Flight applications of unamplified gages on parawing deployment tests are noted. The amplified gages perform accurately in laboratory tests and further experience is needed on performance under dynamic environments.
A Low Cost Approach to Simultaneous Orbit, Attitude, and Rate Estimation Using an Extended Kalman Filter (1998)

An innovative approach to autonomous attitude and trajectory estimation is available using only magnetic field data and rate data. The estimation is performed simultaneously using an Extended Kalman Filter (EKF), a well known algorithm used extensively in onboard applications. The magnetic field is measured on a satellite by a magnetometer, an inexpensive and reliable sensor flown on virtually all satellites in low earth orbit. Rate data is provided by a gyro, which can be costly. This system has been developed and successfully tested in a post-processing mode using magnetometer and gyro data from 4 satellites supported by the Flight Dynamics Division at Goddard. In order for this system to be truly low cost, an alternative source for rate data must be utilized. An independent system which estimates spacecraft rate has been successfully developed and tested using only magnetometer data or a combination of magnetometer data and sun sensor data, which is less costly than a gyro. This system also uses an EKF. Merging the two systems will provide an extremely low cost, autonomous approach to attitude and trajectory estimation. In this work we provide the theoretical background of the combined system. The measurement matrix is developed by combining the measurement matrix of the orbit and attitude estimation EKF with the measurement matrix of the rate estimation EKF, which is composed of a pseudo-measurement which makes the effective measurement a function of the angular velocity. Associated with this is the development of the noise covariance matrix associated with the original measurement combined with the new pseudo-measurement. In addition, the combination of the dynamics from the two systems is presented along with preliminary test results.
Isolation and characterization of a novel polyether antibiotic of the pyrrolether class,antibiotic X-14885A. (1983)

Antibiotic X-14885A is a polyether antibiotic belonging to the class of these natural acid ionophores known as pyrrolethers. The structure of the antibiotic was elucidated by X-ray crystallographic analysis of the hydrated sodium salt, which crystallized as a tetramer containing four antibiotic and water molecules and four atoms of sodium. Antibiotic X-14885A differs from the most well-known member of the class, A-23187, in two respects: the aromatic N-methylamino group present in the latter is replaced by a phenolic hydroxyl, and one of the four aliphatic methyls is replaced by a proton. Antibiotic X-14885A is active against Gram-positive bacteria and the spirochete, Treponema hyodysenteriae.
Improving YBCO Coated Conductors for Applications (2006)

Superconducting power devices made of high temperature superconductors (HTS) can enable megawatt‐class power systems which are lighter in weight and smaller in size than their conventional counterparts. The YBCO coated conductor is expected to be the premiere HTS conductor in making these systems. With advances in YBCO deposition techniques and the establishment of reel‐to‐reel processing, new research should address enhancement of the YBCO coated conductor’s performance. These improvements in the YBCO conductor must include maintaining high critical current densities in fields of a few tesla and minimizing ac losses. This paper first discusses a current sharing scheme in the multifilamentary YBCO conductor to circumvent filamentary breakage. Also, a method for providing magnetic flux pinning to increase the current capacity of the YBCO conductor is outlined using minute additions of rare earth dopants.
Chemically Amplified, Positive Tone, Polynorbornene Dielectric for Microelectronics Packaging (2014)

A low permittivity, positive tone, polynorbornene dielectric has been developed that exhibits excellent lithographic and electrical properties. The polymer resin is a random copolymer of a norbornene hexafluoroalcohol (NBHFA) and a norbornene tert-butyl ester (NBTBE). High optical sensitivity and contrast were achieved using a chemically amplified solubility switching mechanism through the acid-catalyzed deprotection of the tert-butyl ester functionality. After developing in aqueous base, the film was thermally cured through a Fischer esterification reaction, resulting in a cross-linked permanent dielectric. The effect of the photoacid generator (PAG) concentration on the lithographic patterning and curing reactions was studied. Higher PAG loading was favorable for both sensitivity and dielectric constant. The sensitivity of a formulation was measured as low as 8.09 mJ/cm2. The molar ratio of the two monomers composing the polymer was varied. A higher NBHFA content was favorable because it resulted in a lower modulus, lower shrinkage, and lower dielectric constant and loss. A formulation with 70 mol% of the NBHFA had a modulus of 2.60 GPa, a 12.2% volume decrease during cure, and a dielectric constant of 2.23. The direction-dependent coefficient of thermal expansion was measured, and it was found that the anisotropy of the PNB films decreased with higher NBTBE content.
Nearly-Optimal Resource Allocation for Coexisting Industrial Wireless Networks with Line Topologies (2019)

The limited spectrum resources inevitably incur the spectrum sharing among coexisting industrial wireless networks (IWNs), and multiple coexistence IWNs form a heterogeneous environment. An effective resource allocation thus plays a crucial role in coordinating the efficient operations of multiple IWNs. Existing works only study the constrained coexistence problem among specified types of networks with a limited number of nodes over one single channel. In this paper, we investigate a general coexistence problem over multiple channels among arbitrary types of networks with line topologies, and the number of nodes in each network is also arbitrary. We rigorously analyze theoretical scheduling latency of this general coexistence problem, then we propose an algorithm to attain the optimal result. The presented Coexisting Line topology Networks Resource Allocation (CLNRA) algorithm consists of two phases. In the inter-network resource allocation phase, non-overlapped channels are allocated to each network according to the corresponding transmission priority. While in the intra-network resource allocation phase, we filter out the nodes that may generate continuous empty buffers so as to enhance the resource utilization ratio. We also verify the effectiveness of the CLNRA algorithm through extensive simulations. Evaluation results show that the CLNRA algorithm can attain the theoretical optimal result in 99:3% cases, and it has obvious superiorities on resource utilization ratio and scheduling latency.
Abstract 1997: The Rac inhibitors HV-107 and HV-118 as potential therapeutics for metastatic breast cancer (2019)

Breast cancer is the first cause of death in women globally. Metastatic breast cancer is stimated to affect more than a quarter of million of women in the US. Due to the lack of effective treatment, metastasis remains the main cause of breast cancer mortality. Therefore, it is imperative to develop novel effective strategies against metastasis. A promising target for anti-metastatic therapy is the Rho GTPase Rac because it plays a key role in metastatic cancer progression by regulating cellular processes such as adhesion, migration, proliferation and survival. Our group developed Ehop-016, a small molecule that inhibits Rac in metastatic breast cancer cells with an IC 50 =1µM and significantly reduces tumor growth, angiogenesis, and metastasis in a mouse model of metastatic breast cancer. However, its relative bioavailability is moderate and should be improved. Therefore, to find a compound with increased potency and bioavailability, we tested several Ehop-016 derivatives. Using Rac pulldown assays we show that HV-107 and HV-118 inhibit Rac activation by 60% in MDA-MB-231 and MDA-MB-435 metastatic breast cancer cells at 100 and 250nM, respectively. MTT assays show HV-107 (at ≥500nM) and HV-118 (at ≥50nM) significantly inhibit metastatic breast cancer cell viability, while showing minimal toxicity towards non-cancerous cells. Cell cycle analysis by flow cytometry demonstrates a G 2 -M arrest and a prominent sub-G 1 population, indicative of cell death, in metastatic breast cancer cells treated with HV-107 (1000 nM) and HV-118 (100 nM). To evaluate apoptosis as a potential cell death mechanism, we measured caspase 3 activity. Our results show HV-107 and HV-118 significantly induce caspase 3 activity by approximately 1.6-fold at 1000 and 100nM, respectively in metastatic breast cancer cells. Therefore, these Rac inhibitors affect cell viability by inhibiting cell cycle progression and inducing apoptosis. Finally, we tested HV-118 (at 1mg/kg BW) in a mouse model of metastatic breast cancer and found a 30% reduction in tumor growth and a 90% inhibition in metastasis. Taken together, our results indicate HV-107 and HV-118 have potential as anti-breast cancer metastasis therapeutics. This study was supported by awards from the Susan Komen for the Cure, NIH/NIMHHD U54MD008149, and the Puerto Rico Science and Technology Trust to SD; NIH/NCRR R25GM061838 to UPR MSC; NIH/NIMHHD RCMI 8G12MD007583RCMI, Title V PPOHA 031M10505 and Title V Cooperative P031S130068 from U.S. Department of Education to UCC; and and PRINBRE (NIH/NIGMS P20GM103475-13) Sub-Award to LCP. Citation Format: Grace E. Velez, Cornelis Vlaar, Eliud Hernandez, Anibal Valentin, Linette Castillo-Pichardo, Suranganie Dharmawardhane. The Rac inhibitors HV-107 and HV-118 as potential therapeutics for metastatic breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1997.
Multi-channel active control of axial cooling fan noise (2002)

A multi-channel active control system has been applied to the reduction of free-field tonal noise from a small axial cooling fan. The experimental apparatus consists of an aluminum enclosure which houses the fan, an infrared detector-emitter pair which serves as a reference sensor, loudspeakers, microphones, and appropriate filters and amplifiers. The research fan and loudspeakers have been modeled theoretically as point sources to derive a mathematical expression for radiated power. The minimization of this power has served to guide the number and location of control sources, as well as to discover potential error microphone locations in the extreme near-field. Experiments with these microphone positions have shown that there are predictable near-field locations which consistently lead to significant reductions in the global mean-squared pressure for the first four harmonics of the blade passage frequency. For example, a four channel configuration with the error microphones placed appropriately results in global mean-squared pressure reductions on the order of 10 dB or more for the targeted frequencies.
Recovering ultraclean lignins of controlled molecular weight from Kraft black-liquor lignins (2015)

By operating in a region of liquid-liquid equilibrium, hot acetic acid-water mixtures can be used to simultaneously clean, fractionate, and solvate Kraft black-liquor lignins. Lignin-rich liquid phases of controlled molecular weight with key metals contents reduced to <50 ppm are obtained without a washing step.
A Novel Automated Algorithm Effectively Titrates Stimulation in an Implantable Vagus Nerve Stimulation Device (2020)

Autonomic Regulation Therapy (ART) using chronic Vagus Nerve Stimulation (VNS) is in development for patients with heart failure who remain symptomatic despite standard care. In the ANTHEM-HF Pilot Study, a therapeutic VNS intensity was successfully achieved in patients with HFrEF using manually programmed VNS up-titration. An algorithm has been developed for automatically intensifying VNS in small increments to a programmable target intensity, and capable of adjustments during the up-titration process using a hand-held programmer or magnet.
High-Temperature Solid Lubricant Coating (2010)

NASA PS400 is a solid lubricant coating invented for high-temperature tribological applications. This plasma-sprayed coating is a variant of the previously patented PS304 coating, and has been formulated to provide higher density, smoother surface finish, and better dimensional stability. This innovation is a new composite material that provides a means to reduce friction and wear in mechanical components. PS400 is a blend of a nickel-molybdenum binder, chrome oxide hardener, silver lubricant, and barium fluoride/calcium fluoride eutectic lubricant that can either be sprayed or deposited by other means, such as powder metallurgy. The resulting composite material is then finished by grinding and polishing to produce a smooth, self-lubricating surface.
Development of an ammonia pretreatment that creates synergies between biorefineries and advanced biomass logistics models (2022)

Biomass densification allows economic long-distance hauling and enables mega-biorefineries that benefit from economies of scale. COBRA-LE pretreatment uses densified biomass to achieve near-theoretical conversion of carbohydrates and usable lignin.
Demonstration of soft X-ray laser driven by an all diode pumped CPA laser system (2010)

We report the demonstration of an 18.9nm soft x-ray laser pumped by a compact; all diode pumped chirped pulse amplification laser system producing 1J, 8.5ps pulses at 10Hz repetition rate.
Quantifying the three main components of salinity tolerance in cereals (2008)

Salinity stress is a major factor inhibiting cereal yield throughout the world. Tolerance to salinity stress can be considered to contain three main components: Na(+) exclusion, tolerance to Na(+) in the tissues and osmotic tolerance. To date, most experimental work on salinity tolerance in cereals has focused on Na(+) exclusion due in part to its ease of measurement. It has become apparent, however, that Na(+) exclusion is not the sole mechanism for salinity tolerance in cereals, and research needs to expand to study osmotic tolerance and tissue tolerance. Here, we develop assays for high throughput quantification of Na(+) exclusion, Na(+) tissue tolerance and osmotic tolerance in 12 Triticum monococcum accessions, mainly using commercially available image capture and analysis equipment. We show that different lines use different combinations of the three tolerance mechanisms to increase their total salinity tolerance, with a positive correlation observed between a plant's total salinity tolerance and the sum of its proficiency in Na(+) exclusion, osmotic tolerance and tissue tolerance. The assays developed in this study can be easily adapted for other cereals and used in high throughput, forward genetic experiments to elucidate the molecular basis of these components of salinity tolerance.
Nearly Optimal Adaptive Procedure for Piecewise-Stationary Bandit: a Change-Point Detection Approach. (2018)

Multi-armed bandit (MAB) is a class of online learning problems where a learning agent aims to maximize its expected cumulative reward while repeatedly selecting to pull arms with unknown reward distributions. In this paper, we consider a scenario in which the arms' reward distributions may change in a piecewise-stationary fashion at unknown time steps. By connecting change-detection techniques with classic UCB algorithms, we motivate and propose a learning algorithm called M-UCB, which can detect and adapt to changes, for the considered scenario. We also establish an $O(\sqrt{MKT\log T})$ regret bound for M-UCB, where $T$ is the number of time steps, $K$ is the number of arms, and $M$ is the number of stationary segments. % and $\Delta$ is the gap between the expected rewards of the optimal and best suboptimal arms. Comparison with the best available lower bound shows that M-UCB is nearly optimal in $T$ up to a logarithmic factor. We also compare M-UCB with state-of-the-art algorithms in a numerical experiment based on a public Yahoo! dataset. In this experiment, M-UCB achieves about $50 \%$ regret reduction with respect to the best performing state-of-the-art algorithm.
Context management framework and context representation for MNO (2011)

Context Management technology is not novel itself, and ICT companies are already looking at this area and spending effort for a long time trying to find a technically feasible solution, appealing marketing usage and solve all the possible issues with its privacy and security concerns. However, after many years of technology scouting and academic scrutiny within this still innovating area, there is no unique best practice or reference standardization solving all the technological difficulties within this field. The context information available in the real world from many potential sources should be handled in a near real-time way, efficiently processed by many devices and be interoperable among different actors dealing with the context. Therefore not only a comprehensive context management framework shall be in the place but also efficient context representation formalism should be employed in order to represent the context data suitably for an autonomous Machine-to-Machine processing, with all the data maintained within that representation and with all the mechanisms or artifacts needed for a secure and privacy safeguarding sensitive data handling. This all compose a set of requirements to be respected in the context information data representation, which are listed and solved by the solution described within with paper.
Advances and Challenges in Small‐Molecule DNA Aptamer Isolation, Characterization, and Sensor Development (2021)

Abstract Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind to specific molecules with high affinity, and offer a number of advantages relative to antibodies as biorecognition elements in biosensors. However, it remains difficult and labor‐intensive to develop aptamer‐based sensors for small‐molecule detection. Here, we review the challenges and advances in the isolation and characterization of small‐molecule‐binding DNA aptamers and their use in sensors. First, we discuss in vitro methodologies for the isolation of aptamers, and provide guidance on selecting the appropriate strategy for generating aptamers with optimal binding properties for a given application. We next examine techniques for characterizing aptamer–target binding and structure. Afterwards, we discuss various small‐molecule sensing platforms based on original or engineered aptamers, and their detection applications. Finally, we conclude with a general workflow to develop aptamer‐based small‐molecule sensors for real‐world applications.
Comprehensive Enhancement of Nanostructured Lithium-Ion Battery Cathode Materials via Conformal Graphene Dispersion (2017)

Efficient energy storage systems based on lithium-ion batteries represent a critical technology across many sectors including consumer electronics, electrified transportation, and a smart grid accommodating intermittent renewable energy sources. Nanostructured electrode materials present compelling opportunities for high-performance lithium-ion batteries, but inherent problems related to the high surface area to volume ratios at the nanometer-scale have impeded their adoption for commercial applications. Here, we demonstrate a materials and processing platform that realizes high-performance nanostructured lithium manganese oxide (nano-LMO) spinel cathodes with conformal graphene coatings as a conductive additive. The resulting nanostructured composite cathodes concurrently resolve multiple problems that have plagued nanoparticle-based lithium-ion battery electrodes including low packing density, high additive content, and poor cycling stability. Moreover, this strategy enhances the intrinsic advantages of nano-LMO, resulting in extraordinary rate capability and low temperature performance. With 75% capacity retention at a 20C cycling rate at room temperature and nearly full capacity retention at -20 °C, this work advances lithium-ion battery technology into unprecedented regimes of operation.
Novel, Selective Vitamin D Analog Suppresses Parathyroid Hormone in Uremic Animals and Postmenopausal Women (2014)

These results coupled with a pharmacokinetic half-life of ~24 h suggest that 2MD given either daily or at the time of dialysis may be a superior therapy for secondary hyperparathyroidism in chronic renal failure patients.
Speech segmentation using probabilistic phonetic feature hierarchy and support vector machines (2004)

We propose a method that combines a probabilistic phonetic feature hierarchy with support vector machines for segmentation of continuous speech into five classes - vowel, sonorant consonant, fricative, stop and silence. We show that by using the hierarchy, only four binary classifiers are required to recognize the five classes. Due to the probabilistic nature of the hierarchy, the method overcomes the disadvantage of the traditional acoustic-phonetic methods where the error is carried down the hierarchy. In addition, the hierarchical approach allows the use of comparable amount of training data of two classes that each binary classifier is designed to discriminate. The segmentation method with 13 knowledge based parameters performs considerably better than a context-dependent hidden Markov model (HMM) based approach that uses 39 mel-cepstrum based parameters.