gebhart/patrepeval huggingface dataset:
Abstract LB-076: Personal neoantigen immunotherapy in hepatocellular carcinoma (2019)

Abstract Hepatocellular carcinoma (HCC) is one of the most common cancers and the leading causes of mortality in China with limited therapeutic options. To investigate whether neoantigens could induce tumor specific immune responses in patients with HCC, neoantigen stimulating cellular therapy (neo-MASCT) was applied after radical resection. Neo-MASCT was a cell-based immunotherapy with injections of mature dendritic cells (DCs) loaded with a peptide pool of multiple shared tumor associated antigens (TAAs) and several personalized neoantigens followed by autologous T cells stimulated by these DCs. To obtain neoantigens, fresh tumor samples were acquired immediately after biopsy or surgery for subsequently WES and RNAseq. All mutations including SNV, non-frame shift insert/deletion (Indel), and neoORF were detected by comparing NGS data from tumors to normal tissues. All neo-epitope candidates were predicted by our own proprietary algorithm MASNEO according to the patient’s HLA class I genotypes. Long neoantigen peptides containing 25-31 amino acids with higher affinities were selected for further synthesis and treatment. Peptides containing multiple neo-epitopes were preferred. Until now, eight patients had received neo-MASCT, and seven of them were tested for specific immune responses against both TAAs and neoantigens using IFNγ Elispot assay. The results showed that Neo-MASCT induced TAA-specific immune responses in five patients (5/7, 71%), and induced neoantigen-specific immune responses in six patients (6/7, 86%), respectively. One patient demonstrated specific T cell responses against all the five neoantigen peptides (5/5, 100%) after neo-MASCT treatment. The average responsive rate of neoantigens was 65% (22/34 peptides) in the six responding patients. In conclusion, our results demonstrate that neo-MASCT is well-tolerated in HCC patients and elicits immune responses against multiple tumor antigens, especially personalized neoantigens. We will continuously monitor the immune responses against neoantigens, and use the results to train and optimize our predicting algorithm. We will also evaluate the clinical benefit of neo-MASCT in further clinical trials with more patients. Citation Format: Sui Peng, Zhenwei Peng, Lixia Xu, Jie Mei, Longqing Tang, Yanyan Han, Ming Kuang. Personal neoantigen immunotherapy in hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-076.
Properties and Synthesis of Lossless Snubbers and Passive Soft-Switching PWM Converters (2019)

This article investigates the synthesis of lossless snubbers and passive soft-switching converters, as well as their general properties, including topological properties and electrical properties. The aim is to find the possible simplest snubbers and soft-switching converters and to give suggestions on applications of the snubbers and the soft-switching converters. On one hand, the synthesis and the topological properties of the snubbers and the converters determine the complexity of the topologies and help find the least requirement that passive soft switching needs to fulfill. The topological properties are investigated by addressing the basic issues induced by the inductor/capacitor added for passive soft switching. Based on the topological properties, the snubbers and the converters are synthesized. On the other hand, the electrical properties determine the performance of the snubbers and converters, help understand the limitations and are investigated by two case studies accompanied with experimental verification. By investigation of the general properties, the possible simplest snubber is given, the tradeoff between the complexity and performance is discussed in detail, the suggestion of snubber applications is presented, and three kinds of reported passive soft-switching converters which are believed to have the most potential of wide application are discussed.
Amorphous WO3 Films via “Wet” CVD of a WVI Oxoalkoxide Precursor (2001)

Amorphous WO3 films are obtained by using the oxoalkoxide precursor WO(OtBu)4. This compound is easily evaporated at 80 °C, and reacts with water at the surface of the substrate (Si(100) or soda lime glass (KGlass)) to give films of tungsten oxide in a combined CVD sol–gel process. The films deposited at low temperatures (150 °C, Si(100), or 100 °C, KGlass) can be defined as tungstic species (of general formula WOn(OH)m), having interesting electrochromic properties. Thermal treatment at temperatures over 400 °C converts the material to a more typical WO3 film.
Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130 (1999)

Leukemia inhibitory factor (LIF), cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M (OSM) lead to heterodimerization of LIF receptor (LIFR) or the OSM-specific receptor (OSMR) with glycoprotein (gp) 130, the common receptor subunit for IL-6-type cytokines. Thereby intracellular signaling via Janus kinases (Jaks) and STAT transcription factors is initiated. We investigated the contributions of LIFR and OSMR to signal transduction in the context of heterodimers with gp130. Chimeric receptors based on the extracellular parts of the IL-5R alpha- and beta-chains were generated, allowing the induced heterodimerization of two different cytoplasmic tails. Our studies demonstrate that upon heterodimerization with the gp130 cytoplasmic region, the cytoplasmic parts of both LIFR and OSMR were critical for activation of an acute phase protein promoter in HepG2 hepatoma cells. The membrane-proximal region of LIFR or OSMR was crucial for the ability of such receptor complexes to induce DNA binding of STAT1 and STAT3 in COS-7 cells. Membrane-distal regions of LIFR and OSMR contributed to STAT activation even in the absence of gp130 STAT recruitment sites. We further show that the Janus kinases Jak1 and Jak2 constitutively associated with receptor constructs containing the cytoplasmic part of LIFR, OSMR, or gp130, respectively. Homodimers of the LIFR or OSMR cytoplasmic regions did not elicit responses in COS-7 cells but did in HepG2 cells and in MCF-7 breast carcinoma cells. Thus, in spite of extensive functional similarities, differential signaling abilities of gp130, LIFR, and OSMR may become evident in a cell-type-specific manner.
Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? (2019)

Leptin, a hormone that is capable of effectively reducing food intake and body weight, was initially considered for use in the treatment of obesity. However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous administration of leptin. The inability of leptin to exert its anorexigenic effects in obese individuals, and therefore, the lack of clinical utility of leptin in obesity, is defined as leptin resistance. This phenomenon has not yet been adequately characterized. Elucidation of the molecular mechanisms underlying leptin resistance is of vital importance for the application of leptin as an effective treatment for obesity. Leptin must cross the blood-brain barrier (BBB) to reach the hypothalamus and exert its anorexigenic functions. The mechanisms involved in leptin transportation across the blood-brain barrier continue to be unclear, thereby preventing the clinical application of leptin in the treatment of obesity. In recent years, new strategies have been developed to recover the response to leptin in obesity. We have summarized these strategies in this review.
Modified TCP NewReno for wireless networks (2015)

Transmission Control Protocol (TCP) congestion control algorithm works well for the wired networks where most of the timeouts and 3-dupacks are the result of congestion. In the wireless networks, where random segment loss due to bit errors is a dominant concern, the arrival of duplicate acknowledgements or even the retransmission timeouts do not necessarily denote congestion. In those cases, throttling transmission rate is not necessary rather detrimental. For this reason, existing TCP congestion control algorithms fail to perform well in wireless networks. In this paper, we propose a new TCP congestion control algorithm TCP NewReno+ that performs better in wireless networks. We tested our proposed algorithm using the network simulator (ns-2) and it shows better performance than many other TCP variants in the wired, wireless and the mixed networks.
On the Possibility of Chemo-Mechanical Action in Magnetic Float Polishing of Silicon Nitride (1996)

Chromium oxide abrasive has been reported in the literature to provide efficient chemo-mechanical polishing action for silicon nitride ceramic. Since aluminum oxide and chromium oxide abrasives are nearly of the same hardness, magnetic float polishing tests were conducted on silicon nitride balls with these two abrasives to investigate mechanical versus chemo-mechanical aspects of polishing. Tests results show higher removal rates and smoother surface texture (with fewer pits) with chromium oxide abrasive compared to aluminum oxide abrasive. Formation of pits due to brittle fracture seems to be the more predominant mode of material removal with aluminum oxide abrasive than with chromium oxide abrasive. While there may be some mechanical action (abrasion) with chromium oxide abrasive initially, subsequent removal is believed to be due to chemo-mechanical action. This could be due to degeneration of the chromium oxide abrasive (both mechanical and chemical) during polishing. Various hypotheses for the material removal mechanism (both mechanical and chemo-mechanical) were considered. Based on that, the higher removal rates and smoother surface texture on the silicon nitride balls with chromium oxide abrasive in semifinish polishing is interpreted here as possibly due to chemo-mechanical action. Higher chemical stability of aluminum oxide abrasive (compared to chromium oxide abrasive) and the known role of chromium oxide as a catalyst for the oxidation of silicon nitride are some of the reasons attributed for this action.
Teach yourself Access 97 in 21 days (1998)

In just 21 days, you'll have all the skills you need to get up and running efficiently. With this complete tutorial, you'll master the basics and then move on to the more advanced features and concepts. Understand the fundamentals of data management and retrieval. Master all of the new and advanced features that Access 97 offers. Learn how to effectively use the latest tools and features to create customized forms and reports by following practical, real-world examples. Get expert tips from a leading authority on implementing Access 97 in the corporate environment or on the Web. This book is designed for the way you learn. Go chapter by chapter through the step-by-step lessons, or just choose the lessons that interest you the most.
Gadolinium Complex of DO3A-benzothiazole Aniline (BTA) Conjugate as a Theranostic Agent (2013)

A gadolinium complex of 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) and benzothiazole-aniline (BTA) of the type [Gd(DO3A-BTA)(H2O)] has been prepared for use as a single molecule theranostic agent. The kinetic inertness and r1 relaxivity (= 3.84 mM(-1) s(-1)) of the complex compare well with those of structurally analogous Gd-DOTA. The same complex is not only tumor-specific but also intracellular, enhancing MR images of cytosols and nuclei of tumor cells such as MCF-7, MDA-MB-231, and SK-HEP-1. Both DO3A-BTA and Gd(DO3A-BTA) reveal antiproliferative activities as demonstrated by GI50 and TGI values obtainable from the cell counting kit-8 (CCK-8) assays performed on these cell lines. Ex vivo and in vivo monitoring of tumor sizes provide parallel and supportive observations for such antiproliferative activities.
Lymphocyte stimulation by gangliosides, cerebrosides and basic protein in juvenile rheumatoid arthritis. (1981)

Peripheral blood lymphocytes from patients with juvenile rheumatoid arthritis (JRA), patients with neurological diseases (ND) and healthy children were tested for reactivity to gangliosides, cerebrosides and basic protein (BP) by the active E-rosette test (AER). None of the lymphocytes from ND patients, healthy children or two children with psoriatic arthritis responded by increased rosette formation to gangliosides, cerebrosides and BP. Lymphocytes from all 16 children with JRA were sensitized to at least one antigen as shown by the AER test. The percentage of active T-cells was significantly lower (p less than or equal to 0.05)( in children with JRA as compared to others. The significance of the results in relation to immunopathogenesis of JRA is discussed.
Evaluation of Liver Metastases After Radiofrequency Ablation: Utility of <sup>18</sup>F-FDG PET and PET/CT (2005)

(18)F-FDG PET and PET/CT can provide added diagnostic information compared with conventional imaging in patients after radiofrequency ablation of liver metastases and can be useful in guiding repeat ablation procedures.
Salt−Induced Cloud Point in Anionic Surfactant Solutions:  Role of the Headgroup and Additives (2002)

Anionic surfactants are not known to show a clouding phenomenon in aqueous solutions. On the other hand, this is a general feature for nonionic surfactants. Here the effect of addition of tetra-n-butylammonium bromide (Bu4NBr) on the clouding phenomenon in sodium dodecylbenzenesulfonate (SDBS) has been studied by measuring cloud points (CP) for each combination. Similar type of studies were also performed with poly(ethylene glycol) t-octylphenyl ether (TX-100). The CP varies in an opposite manner for the two classes of surfactants, which is explained in terms of charge variation in each type of micelles by the addition of Bu4NBr. A relationship between [SDBS] vs [Bu4NBr] has been worked out for getting the CP − phenomenon in SDBS solutions: nearly one Bu4NBr molecule is needed for each two SDBS monomers for getting the CP in the system. With 10-mM SDBS, the addition of Bu4NBr shows an interesting phase behavior, where a stable colloidal phase with bluish − white appearance (preclouded) appears preceded by conventional clouding. Effects of the addition of ureas (urea and tetramethylurea), thioureas (thiourea and tetramethylthiourea), amino acids (glycine, alanine, leucine and phenylalanine), and sugars (xylose, arabinose and dextrose) have also been seen on the 50-mM SDBS + 35-mM Bu4NBr system (this system was chosen because its CP has a wider window available for variations below and above the CP). Ureas and thioureas affect the CP in different manners, which are explained in the light of indirect and direct interactions with micelles. CP variation in the presence of amino acids depends on their polar and hydrophobic nature. On the other hand, sugars behave in a manner similar to their effect on solubility of hydrophobic compounds in aqueous solutions.
[Correlation of plasma endothelin and multiple organ dysfunction syndrome caused by acute paraquat poisoning]. (2005)

Endothelin may be involved in the pathogenesis of MODS caused by APP, plasma ET may be one of a clinical index for evaluating the degree of multiple organ function damage, for guiding treatment, and judging the prognosis of MODS caused by APP.
Tunable Microwave Photonic Filter Based on Silicon Nitride MZI-Assist Micro-Ring Resonator (2019)

We study a tunable microwave photonic filter by a MZI-assist MRR structure with a high thermo-optic tuning efficiency utilizing SiNx material platform, showing a wide central frequency tuning range over a FSR of 50 GHz, with a tuning efficiency of 0.0115 nm/mW, thanks to the cantilever adiabatic waveguide structure. A maximum extinction ratio of 22 dB at 1553.46 nm wavelength with the high quality factor of 1.2 × 105 can be achieved by tuning the coupling rate between the bus waveguide and the ring resonator.
Effects of target structure on the properties of MO recoding media produced in a large-scale vertical in-line sputtering system (1988)

The metallurgical states of rare-earth-transition-metal targets were found to have a significant effect on the performance of magnetooptical (MO) recording thin films. Polar Kerr MO hysteresis loops of the films were measured as a function of temperature at a HeNe laser wavelength. B-H hysteresis loops were measured by a vibrating sample magnetometer at the room temperature. The study indicates that in a vertical in-line sputtering system, a rectangular alloy target containing about 25% of the intermetallic phase produces a negligibly small composition gradient in DC-magnetron-sputtered films. With a proper aperture to mask off oblique incident coating flux, coercivity and thickness variations of less than +or-5 and +or-2% have been achieved reproducibly on 5.25-in disks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Digital Technology for AMD Management in the Post-COVID-19 New Normal (2021)

Digitalization strategies and developments are currently ongoing and underway to ensure early detection, stability and visual improvement in patients suffering from AMD in this COVID-19 era. This may set a precedence for the post COVID-19 new normal where digital platforms may be routine, standard and expected in healthcare delivery.
Prostatic irradiation-induced sexual dysfunction: A review and multidisciplinary guide to management in the radical radiotherapy era (Part III on Psychosexual Therapy and the Masculine Self-Esteem) (2020)

Psychological morbidity, sexuality, and health/system information have been identified as the highest areas of support needs in patients undergoing management of their prostate cancer (PCa). Management of a patient's sexual function prior to, during and after PCa radiotherapy requires multidisciplinary coordination of care between radiation oncologists, urologists, dermatologists, pharmacists, and psychiatrists. The finale of this three-part review provides a framework for clinicians to better understand the role of mental healthcare providers in the management of sexual toxicities associated with prostatic radiotherapy. The authors recommend that patients be referred for psychological evaluation and possibly to individual, couples or group general or cognitive behavioral sex therapy at the time of their PCa diagnosis, for a more specialized focus on management of sexual toxicities and sexual recovery. The importance and implications of the masculine self-esteem, sexual orientation, gender identification, cultural expectations, relationship status and patient education are reviewed. Well-informed patients tend to have a better quality of life outcomes compared to patients that take on a passive role in their cancer management.
The nucleotide sequence of citrus leaf rugose ilarvirus RNA-2 (1994)

The nucleotide sequence of citrus leaf rugose ilarvirus (CiLRV) RNA-2 consists of 2990 nucleotides and contains one open reading frame (ORF) which encodes a deduced translation product of 832 amino acids with a calculated M(r) of 95,501 (95K). The 5' terminus of the RNA has a m7Gppp cap. Both the nucleotide sequence of CiLRV RNA-2 and its translated polypeptide share homologies with the nucleotide sequence and translated polypeptide, respectively, of RNA-2 of alfalfa mosaic virus (AlMV). The homology occurs in the central region of both the nucleic acid sequence and the polypeptide. Homologies between either CiLRV or AlMV and other Bromoviridae (cucumber mosaic virus--CMV, brome mosaic virus--BMV and cowpea chlorotic mottle virus--CCMV) were far less. Alignment of the 104 amino acid region (polymerase signature) of the 95K protein against 10 other 'alpha-like' plant viral polymerase signatures showed that CiLRV and AlMV are more closely related to each other than to CMV, BMV or CCMV. This is the first report of the full-length sequence of RNA-2 of an ilarvirus.
Probing the Mechanism of Olefin Metathesis in Grubbs–Hoveyda and Grela Type Complexes (2010)

The more the better: Kinetic data derived from UV/Vis spectroscopy (see picture) provide conclusive evidence for participation of the olefinic substrate in the rate-limiting step of the initiation reaction of Grubbs–Hoveyda type olefin metathesis catalysts, and for a second olefin-independent step, which is rate-limiting only at very high olefin concentrations.
Signal and interference statistics of a CDMA system with feedback power control. II (1994)

For pt.I see ibid., vol 41, p.1626-34 (1993). Power control is essential in the use of direct-sequence code division multiple-access (CDMA) techniques. Early system-level performance analyses of a CDMA approach to wireless mobile and personal communications have assumed the ability of power control to equalize the absolute signal powers of CDMA users received at each base station. The present paper studies a more practical, although analytically more complicated, uplink power control technique that uses measurements of the received signal-to-interference ratio (SIR) instead. A combination of discrete-event link simulation and analysis of the obtained SIR statistics is used to explore the previously little-known behavior of a CDMA system using SIR-based power control and to obtain performance estimates for such a system under various operating assumptions. The overall results indicate that power control based on SIR has the potential for somewhat higher system performance than power control based on absolute signal strength assumed in the early analyses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High Quality Blind Bandwidth Extension of Audio for Portable Player Applications (2006)

This convention paper has been reproduced from the author&apos;s advance manuscript, without editing, corrections, or consideration by the Review Board. The AES takes no responsibility for the contents. Additional papers may be obtained by sending request
High-power soliton-induced supercontinuum generation and tunable sub-10-fs VUV pulses from kagome-lattice HC-PCFs (2010)

We theoretically study a novel approach for soliton-induced high-power supercontinuum generation by using kagome lattice HC-PCFs filled with a noble gas. Anomalous dispersion and broad-band low loss of these fibers enable the generation of two-octave broad spectra by fs pulses, with high coherence and high spectral peak power densities up to five orders of magnitude larger than in standard PCFs. In addition, up to 20% of the output radiation energy forms a narrow UV/VUV band, which can be tuned by controlling the pressure in the range from 350 nm to 120 nm. In the temporal domain this corresponds to sub-10-fs UV/VUV pulses with pulse energy of few tens of microJ, caused by the formation of a high-order soliton emitting non-solitonic radiation.