gebhart/patrepeval huggingface dataset:
Temperature‐Controlled Assembly and Release from Polymer Vesicles of Poly(ethylene oxide)‐<i>block</i>‐ poly(<i>N</i>‐isopropylacrylamide) (2006)

Narrow-dispersity thermoresponsive block copolymers of poly(ethylene oxide)-block-poly(N-isopropylacrylamide) self-assemble into vesicles at temperatures above 32 °C. The vesicles integrate a hydrophobic fluorescent dye into their membranes and encapsulate the hydrophilic anticancer drug doxorubicin. Temperature-controlled release of the dye through disintegration of the vesicles takes place at temperatures below 32 °C, as shown in the figure.
Abstract 1733: Development of chemical tools to study the endogenous Hsp70 interactome in malignant cells (2015)

Abstract Background: Heat shock protein 70 family members play an important role in cancer. They are up-regulated in wide variety of tumors and the increased Hsp70 protein expression correlates with metastases, resistance to treatment and poor prognosis. Multiple mechanisms explain cancer cells dependence on Hsp70, such as inhibition of apoptosis by Hsp70, induction of autophagy and control of stability of onco-proteins. These Hsp70 activities are mediated in cancer by its ability to chaperone and interact with a large number of proteins in a cell-specific, context dependent manner. Hypothesis: Reagents that enable the capture of tumor-specific Hsp70 complexes facilitate the identification of context-dependent Hsp70 interactomes. Results: Our laboratory recently reported the identification of a novel allosteric site located in the nucleotide binding domain of Hsp70 (Chem Biol 2013). It has also reported the discovery of ligands that bind to the allosteric pocket of Hsp70, inhibit its function in cancer cells and result in anti-cancer activity (J Med Chem 2013). Structure-activity relationship studies in this ligand series gave insights on the attachment of specific linkers for the design of Hsp70-related chemical tools. Here we present the design of Hsp70-directed reagents and use biochemical and cell-based methods to validate Hsp70-directed affinity purification probes. We demonstrate that these tools lock Hsp70 in complex with onco-client proteins and effectively isolate Hsp70 complexes for identification through biochemical techniques. Using these tools we provide proof-of-concept analyses that glimpse into the complex roles played by Hsp70 in maintaining a multitude of cell-specific malignancy-driving proteins. Significance: The knowledge derived from the use of such reagents will be extremely valuable not only to understand tumor-specific roles of Hsp70 and associated mechanisms but also to develop rational strategies for the clinical implementation of these agents to cancer treatment. They may also provide clues on the altered functional proteome in individual tumors, a quest yet elusive by today's proteomics methods. Citation Format: Anna A. Rodina, Tony Taldone, Yanlong Kang, Pallav Patel, John Koren, Pengrong Yan, Erica DaGama Gomes, Chenghua Yang, Maulik Patel, Liza Shrestha, Stefan Ochiana, Ronnie Maharaj, Alexander Gozman, Marc Cox, Hediye Erdjument-Bromage, Ronald Hendrickson, Leandro Cerchietti, Ari Melnick, Monica Guzman, Gabriela Chiosis. Development of chemical tools to study the endogenous Hsp70 interactome in malignant cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1733. doi:10.1158/1538-7445.AM2015-1733
Precision Olfactory Delivery (POD®) of Drugs for Neurological Disease: A Safety, Tolerability and Comparative Bioavailability Study of POD Dihydroergotamine Mesylate (INP104) to Approved IV D.H.E. 45® and Migranal® Nasal Spray. (P2.10-022) (2019)

Impel NeuroPharma has developed the Precision Olfactory Delivery (POD®) device to achieve consistent medicine delivery to the upper nasal cavity giving rapid uptake and higher bioavailability relative to standard nasal sprays. This study with dihydroergotamine mesylate (DHE) for migraine treatment compares safety, tolerability, bioavailability and pharmacokinetics (PK) of INP104 with IV and traditional nasal delivery of DHE.
Panacea: Automating Attack Classification for Anomaly-based Network Intrusion Detection Systems (2009)

Anomaly-based intrusion detection systems are usually criticized because they lack a classication of attack, thus security teams have to manually inspect any raised alert to classify it. We present a new approach, Panacea, to automatically and systematically classify attacks detected by an anomaly-based network intrusion detection system.
Second-generation color filter array and demosaicking designs (2008)

Recent developments in spatio-spectral sampling theory for color imaging devices show that the choice of color filter array largely determines the spatial resolution of color images achievable by subsequent processing schemes such as demosaicking and image denoising. This paper highlights the cost-effectiveness of a new breed of color filter array patterns based on this sampling theory by detailing an implementation of the demosaicking method consisting of entirely linear elements and comprising a total of only ten add operations per full-pixel reconstruction. With color fidelity that rivals the state-of-the-art interpolation methods and an order of complexity near to that of the bilinear interpolation, this joint sensor-demosaicking solution to digital camera architectures can fulfill the image quality and complexity needs of future digital multimedia simultaneously.
Efficient authentication and key distribution in wireless IP networks (2003)

Emerging broadband access technologies such as 802.11 are enabling the introduction of wireless IP services to an increasing number of users. Market forecasts suggest that a new class of network providers, commonly referred to as wireless Internet service providers, will deploy public wireless networks based on these new technologies. In order to offer uninterrupted IP service combined with ubiquitous seamless mobility, these multiprovider networks need to be integrated with each other, as well as with wide-area wireless technologies such as third-generation cdma2000 and UMTS. Therefore, efficient authentication and dynamic key exchange protocols that support heterogeneous domains as well as networks with roaming agreements across trust boundaries are key to the success of wide-area wireless IP infrastructures. In this article we first describe a simple network model that accounts fro heterogeneity in network service providers, and put forward the requirements any authentication and key exchange protocol that operates in such a model should satisfy, in terms of network efficiency, security, and fraud prevention. We then introduce a new authentication and key exchange protocol, wireless shared key exchange (W-SKE). We characterize properties and limitations of the W-SKE against the requirements discussed earlier. Finally, we contrast W-SKE against other well-known and emerging approaches.
Single-stage, single-switch, isolated power supply technique with input-current shaping and fast output-voltage regulation for universal input-voltage-range applications (2002)

A new single-stage, single-switch, input-current shaping (S/sup 4/ICS) technique which combines the boost-like input-current shaper with a continuous-conduction-mode DC/DC output stage is described. In this technique, the boost inductor can operate in both the discontinuous and continuous conduction modes. Due to the ability to keep a relatively low voltage (<450 Vdc) on the energy-storage capacitor, this technique is suitable for the universal line voltage applications. The voltage on the energy-storage capacitor is kept within the desirable range by the addition of two transformer windings. The principle of operation of the S/sup 4/ICS circuit with forward DC/DC converter is presented. Experimental results obtained on a 100-W (5-V/20-A) prototype circuit are also given.
Rapid measurement of individual cone photoreceptor pointing using focus diversity (2015)

A novel method is presented to rapidly measure the pointing direction of individual human cone photoreceptors using adaptive-optics (AO) retinal imaging. For a fixed entrance pupil position, the focal plane is rapidly modulated to image the guided light in various axial planes. For cones with different pointing directions, this focus diversity will cause a shift in their apparent position, allowing for their relative pointing to be determined. For four normal human subjects, retinal images were acquired, registered, and the positions of individual cones tracked throughout the dataset. Variation in cone tilt was 0.02 radians, agreeing with other objective measurements on the same subjects at the same retinal locations.
Surface acoustic wave device (2008)

A surface acoustic wave device that can operate in alternate-phase mode and single-phase mode, and thus generate surface acoustic waves at two different frequencies. The device is based on a piezoelectric film deposited on an elastic substrate, and includes an electrode layer patterned as two interdigital electrodes and electrical source (2). The device is operated in alternate-phase mode by connecting the two electrodes to different ends of an electrical source (22). The device is operated in single-phase mode by connecting the two electrodes to the same end of an electrical source.
Inferring Periodic Variability of Private Market Returns as Measured by σ from the Range of Value (Wealth) Outcomes over Time (1999)

This article offers an objective mechanism for computing the periodic risk of a private investment portfolio. Such determination was derived by examining the dispersion of the portfolio investments’ terminal wealth. A portfolio manager can use the tools offered to compare the risks and returns of private and public market investments and to determine optimal asset allocation. Additionally, in evaluating private investment managers, a portfolio manager can use the equations derived in this article to determine the implied periodic risks being taken.
Ability of combined Near-Infrared Spectroscopy-Intravascular Ultrasound (NIRS-IVUS) imaging to detect lipid core plaques and estimate cap thickness in human autopsy coronary arteries (2016)

The ability to determine plaque cap thickness during catheterization is thought to be of clinical importance for plaque vulnerability assessment. While methods to compositionally assess cap integrity are in development, a method utilizing currently available tools to measure cap thickness is highly desirable. NIRS-IVUS is a commercially available dual imaging method in current clinical use that may provide cap thickness information to the skilled reader; however, this is as yet unproven. Ten autopsy hearts (n=15 arterial segments) were scanned with the multimodality NIRS-IVUS catheter (TVC Imaging System, Infraredx, Inc.) to identify lipid core plaques (LCPs). Skilled readers made predictions of cap thickness over regions of chemogram LCP, using NIRS-IVUS. Artery segments were perfusion fixed and cut into 2 mm serial blocks. Thin sections stained with Movat’s pentachrome were analyzed for cap thickness at LCP regions. Block level predictions were compared to histology, as classified by a blinded pathologist. Within 15 arterial segments, 117 chemogram blocks were found by NIRS to contain LCP. Utilizing NIRSIVUS, chemogram blocks were divided into 4 categories: thin capped fibroatheromas (TCFA), thick capped fibroatheromas (ThCFA), pathological intimal thickening (PIT)/lipid pool (no defined cap), and calcified/unable to determine cap thickness. Sensitivities/specificities for thin cap fibroatheromas, thick cap fibroatheromas, and PIT/lipid pools were 0.54/0.99, 0.68/0.88, and 0.80/0.97, respectively. The overall accuracy rate was 70.1% (including 22 blocks unable to predict, p = 0.075). In the absence of calcium, NIRS-IVUS imaging provided predictions of cap thickness over LCP with moderate accuracy. The ability of this multimodality imaging method to identify vulnerable coronary plaques requires further assessment in both larger autopsy studies, and clinical studies in patients undergoing NIRS-IVUS imaging.
Water-Borne Block and Statistical Copolymers Synthesized Using Atom Transfer Radical Polymerization (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTWater-Borne Block and Statistical Copolymers Synthesized Using Atom Transfer Radical PolymerizationKrzysztof Matyjaszewski, Devon A. Shipp, Jian Qiu, and Scott G. GaynorView Author Information Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213 Cite this: Macromolecules 2000, 33, 7, 2296–2298Publication Date (Web):March 14, 2000Publication History Received5 October 1999Revised7 February 2000Published online14 March 2000Published inissue 1 April 2000https://pubs.acs.org/doi/10.1021/ma991672ghttps://doi.org/10.1021/ma991672grapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views444Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymerization,Monomers,Polymers,Radical polymerization,Styrenes Get e-Alerts
Feature transformation of biometric templates for secure biometric systems based on error correcting codes (2008)

Secure storage of biometric templates is extremely important because a compromised biometric cannot be revoked and replaced an unlimited number of times. In many approaches proposed for secure biometric storage, an error correcting code (ECC) is applied to the enrollment biometric and the resulting parity or syndrome symbols are stored on the access control device, instead of the original biometric. The principal challenge here is that most standard ECCs are designed for memoryless channel statistics, whereas the variations between enrollment and probe biometrics have significant spatial correlation. To address this challenge, we propose to transform the original biometric into a feature vector that is explicitly matched to standard ECCs, thereby improving the security-robustness tradeoff of the overall biometric system. As a concrete example, we transform fingerprint minutiae maps into feature vectors compatible with ECCs designed for a binary symmetric channel. We conduct a statistical analysis of these feature vectors and show how our feature transformation algorithm may be combined with Low-Density Parity Check (LDPC) codes to obtain a secure fingerprint biometric system.
A Multi-Dimensional Holomorphic Embedding Method to Solve AC Power Flows (2017)

It is well-known that ac power flows of a power system do not have a closed-form analytical solution in general. This paper proposes a multi-dimensional holomorphic embedding method that derives analytical multivariate power series to approach true power flow solutions. This method embeds multiple independent variables into power flow equations and hence, can, respectively, scale power injections or consumptions of selected buses or groups of buses. Then, via a physical germ solution, the method can represent each bus voltage as a multivariate power series about symbolic variables on the system condition so as to derive approximate analytical power flow solutions. This method has a non-iterative mechanism unlike the traditional numerical methods for power flow calculation. Its solution can be derived offline and then evaluated in real time by plugging values into symbolic variables according to the actual condition, so the method fits better into online applications, such as voltage stability assessment. The method is first illustrated in detail on a 4-bus power system and then demonstrated on the IEEE 14-bus power system considering independent load variations in four regions.
Vertical-Bloch-Line Memory (1993)

Vertical-Bloch-line memory is developmental very-large-scale integrated-circuit block-access magnetic memory. Stores data in form of localized pairs of twists (VBL pairs) in magnetic field at edge of ferromagnetic domain in each stripe. Presence or absence of VBL pair at bit position denotes one or zero, respectively. Offers advantages of resistance to ionizing radiation, potential areal storage density approximately less than 1 Gb/cm squared, data rates approximately less than 1 Gb/s, and average access times of order of milliseconds. Furthermore, mass, volume, and demand for power less than other magnetic and electronic memories.
Selective Elimination of Fibroblasts From Pancreatic Islet Monolayers by Basic Fibroblast Growth Factor–Saporin In Mitotoxin (1990)

Fibroblast proliferation regularly impedes the initiation and maintenance of pancreatic islet monolayers in culture. We recently characterized a specific cytotoxin to cells expressing the basic fibroblast growth factor receptor by conjugating the growth factor to saporin-6, a ribosome-inactivating protein. In contrast to untreated islets, isolated adult rat islets grown on a substrate prepared from bovine corneal endothelial cells and incubated with the mitotoxin at 10-nM concentration for 96 h were free of contaminating fibroblasts. Histological and functional studies revealed there was no damage to the islets. The results suggest that treatment of this cell type with basic fibroblast growth factor mitotoxins may be an important tool for culture of pure islets for physiological and clinical studies.
Induction of antitumor immunity by an anti-idiotype antibody mimicking carcinoembryonic antigen. (1997)

Carcinoembryonic antigen (CEA) is a tumor-associated antigen expressed on most gastrointestinal adenocarcinomas and is a putative target for cancer immunotherapy. We developed a murine monoclonal anti-idiotype (anti-Id) antibody, 3H1, which mimics a specific epitope of CEA, for cancer immunotherapy. In this study, the efficacy of 3H1 as a tumor vaccine was evaluated in a murine tumor model. In this model, the murine colorectal cancer cell line MC-38 was transduced with the human CEA gene and injected into syngeneic C57BL/6 (H-2b) mice. Immunization of naive mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humoral and cellular anti-3H1 as well as anti-CEA immunity. Mice immunized with 3H1 were protected against a challenge with lethal doses of MC-38-cea, whereas no protection was observed when 3H1 vaccinated mice were challenged with CEA negative MC-38 cells or when mice were vaccinated with an unrelated anti-Id antibody and challenged with MC-38-cea cells (P < 0.003). These data demonstrate that the 3H1 vaccine can induce protective CEA-specific antitumor immunity.
Precise subpixel estimation on area‐based matching (2002)

Abstract Area‐based matching is a common procedure in various fields such as image‐based measurements, stereo image processing, and fluidics. Subpixel estimation using parabola fitting over three points with their similarity measures is also a common method to increase the resolution of matching. However, few investigations or studies concerning the characteristics of this estimation have been reported. In this paper, we have analyzed the subpixel estimation error by using an approximate image function and three kinds of similarity measures for matching. The results illustrate some inherently problematic phenomena such as so‐called “pixel‐locking.” In addition, we propose a new algorithm to greatly reduce subpixel estimation error. This method is independent of the similarity measure and quite simple to implement. The advantage of our novel method is confirmed through experiments using three different types of images. © 2002 Wiley Periodicals, Inc. Syst Comp Jpn, 33(7): 1–10, 2002; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/scj.10098
Sensitive detection of type G botulinum neurotoxin through Endopep-MS peptide substrate optimization (2019)

Clostridium botulinum produces botulinum neurotoxins (BoNTs) that are one of the most poisonous substances. In order to respond to public health emergencies, there is a need to develop sensitive and specific methods for detecting botulinum toxin in various clinical matrices. Our laboratory has developed a mass spectrometry-based Endopep-MS assay that is able to rapidly detect and differentiate BoNT serotypes A-G by immunoaffinity capture of toxins and detection of unique cleavage products of peptide substrates. To improve the sensitivity of the Endopep-MS assay for the detection of BoNT serotype G, we report here the optimization of synthetic peptide substrates through systematic substitution, deletion, and incorporation of unnatural amino acids. Our data show that the resulting optimized peptides produced a significant improvement (two orders of magnitude) in assay sensitivity and allowed the detection of 0.01 mouseLD<sub>50</sub> toxin present in buffer solution.
Optical forces arising from phase gradients (2009)

Optical traps use forces exerted by specially structured beams of light to localize microscopic objects in three dimensions. In the case of single-beam optical traps, such as optical tweezers, trapping is due entirely to gradients in the light's intensity. Gradients in the light field's phase also control optical forces, however, and their quite general influence on trapped particles' dynamics has only recently been explored in detail. We demonstrate both theoretically and experimentally how phase gradients give rise to forces in optical traps and explore the sometimes surprising influence of phase-gradient forces on trapped objects' motions.
Vascular Deformation Mapping of Abdominal Aortic Aneurysm (2021)

Abdominal aortic aneurysm (AAA) is a complex disease that requires regular imaging surveillance to monitor for aneurysm stability. Current imaging surveillance techniques use maximum diameter, often assessed by computed tomography angiography (CTA), to assess risk of rupture and determine candidacy for operative repair. However, maximum diameter measurements can be variable, do not reliably predict rupture risk and future AAA growth, and may be an oversimplification of complex AAA anatomy. Vascular deformation mapping (VDM) is a recently described technique that uses deformable image registration to quantify three-dimensional changes in aortic wall geometry, which has been previously used to quantify three-dimensional (3D) growth in thoracic aortic aneurysms, but the feasibility of the VDM technique for measuring 3D growth in AAA has not yet been studied. Seven patients with infra-renal AAAs were identified and VDM was used to identify three-dimensional maps of AAA growth. In the present study, we demonstrate that VDM is able to successfully identify and quantify 3D growth (and the lack thereof) in AAAs that is not apparent from maximum diameter. Furthermore, VDM can be used to quantify growth of the excluded aneurysm sac after endovascular aneurysm repair (EVAR). VDM may be a useful adjunct for surgical planning and appears to be a sensitive modality for detecting regional growth of AAAs.