gebhart/patrepeval huggingface dataset:
Modeling and Verification of an Innovative Active Pneumatic Vibration Isolation System (2008)

This paper presents a novel concept in active pneumatic vibration isolation. The novelty in the concept is in utilizing an air-spring-orifice-accumulator combination to vary the natural frequency as well as inject damping into the system per requirement, thereby eliminating the need for a hydraulic cylinder or a magnetorheological damper. This continuously variable natural frequency and damping (CVNFD) technology is aimed at achieving active vibration isolation. For analysis purposes, a particular application in the form of pneumatic seat suspension for off-road vehicles is chosen. A mathematical model representing the system is derived rigorously from inertial dynamics and first principles in thermodynamics. Empirical corelations are also used to include nonlinearities such as friction that cannot be accounted for in the thermodynamic equations. An exhaustive computational study is undertaken to help understand the physics of the system. The computational study clearly depicts the CVNFD capability of the vibration isolation system. An experimental test rig is built to experimentally validate analytical and simulation modeling of the system. Experimental verification corroborated the variable natural frequency and damping characteristic of the system observed through computational simulations.
<i>Trans</i> -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat (1985)

Human T-cell leukemia virus type III (HTLV-III) was recently identified as the probable etiologic agent of the acquired immune deficiency syndrome (AIDS). Here it is shown that, in human T-cell lines infected with HTLV-III, gene expression directed by the long terminal repeat sequence of this virus is stimulated by more than two orders of magnitude compared to matched uninfected cells. The rate of transcription of the HTLV-III long terminal repeat is more than 1000 times that of the SV40 early promoter in one infected cell line. Thus, HTLV-III, like HTLV-I, HTLV-II, and the bovine leukemia virus, is characterized by trans-activation of transcription in infected cells. The efficiency of trans-activation in the case of HTLV-III may account, at least in part, for the virulent nature of HTLV-III infection.
Transvenous defibrillator implantation in patients with persistent left superior vena cava and right superior vena cava atresia (1995)

In this report a transvenous cardioverter defibrillator implantation is described in two patients with a persistent left-sided superior vena cava and right SVC atresia. In the first case, manoeuvring of the guide wire inserted through the left subclavian vein into the SVC proved impossible, revealing a left SVC originating from the left brachiocephalic vein with an acute corner. Changing the side of implantation and inserting a CPI Endotak catheter through the right subclavian vein, the lead was easily advanced through the left SVC into the coronary sinus and then into the right atrium with the tip abutting the lateral atrial wall. Subsequent manoeuvres allowed passage of the tip of the catheter into the right ventricular apex with the proximal defibrillation coil of the Endotak lead in the low left SVC, with its distal limit at the junction with the coronary sinus. A biphasic waveform single pathway RV - > left SVC successfully defibrillated with a stored energy of 5 J. In the second patient, implantation of a transvenous Medtronic system was possible from a left infraclavicular approach. A tripolar RV coil was inserted into the right ventricle via the persistent left SVC and contiguous coronary sinus. Because of the acute angle required to enter the RV in this second case, the RV lead was looped in the right atrium in order to enter the RV in a satisfactory, albeit atypical RV location. This patient was successfully defibrillated with a 5 J monophasic waveform delivered between the RV coil, a CS/left SVC coil, and a subcutaneous patch. In conclusion, both of these patients illustrate the ability to use transvenous ICDs successfully in patients with persistent left superior vena cava although the implantation technique deviates substantially from traditional methods.
Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052) (2007)

A novel enantioselective total synthesis of 20S proteasome inhibitor Salinosporamide A (NPI-0052; 1) is presented. Key features include intramolecular aldol cyclization of 6 to simultaneously generate the three chiral centers of advanced intermediate 5, cyclohexene ring addition using B-2-cyclohexen-1-yl-9-BBN, and inversion of the C-5 stereocenter by oxidation followed by enantioselective enzymatic reduction.
High-efficiency 60 GHZ antenna fabricated using low-cost silicon micromachining techniques (2007)

In this paper, a miniature, multi-functional Si-based packaging technology which can reduce the size and cost and increase the performance of a wide range of millimeter wave systems is proposed. High density capacitors, low temperature coefficient resistors, high-Q inductors, low-loss transmission lines, filters and antennas can all be built within the Si package using standard semiconductor fabrication methods with very high manufacturing precision compared to conventional packaging technologies. Fine pitch metal bumps can be used to attach RF IC's and other components, while bonding can provide hermetic sealing where required. Vias through the Si package eliminates inductive bond wires and minimize parasitics at millimeter wave frequencies. By integrating both antenna and an RF IC in one single package, all high frequency signals are confined within the package and only baseband signals connected to the external package.
Abstract 4287: Ets-related gene (Erg) expression in developing and adult mouse tissues (2011)

Abstract Oncogenic activation of the ETS Related Gene (ERG) in human neoplasms was originally identified in subsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostate cancers. Expression of human ERG protein and consequently its functions in normal and disease states needs to be better understood in light of its suggested role in cell differentiation and proliferation. In this study, we analyzed temporal and spatial expression of the Erg protein by immunohistochemical analysis during mouse embryonic and adult organogenesis using a highly specific ERG monoclonal antibody (CPDR ERG-MAb) developed by our group. Initially, we evaluated the specificity of three recently available ERG monoclonal antibodies (Epitomics EPR 3864 and EPR 3863, and CPDR ERG-MAb) using ERG expressing MOLT4, KG1, COLO 320, VCaP tumor cell lines and LNCaP, MCF7, Jurkat cell lines that do not express ERG. Unlike, rabbit monoclonal antibodies to ERG obtained from Epitomics, the ERG MAb did not show cross reactivity to FLI-1 or to the other ETS related proteins. Our comprehensive evaluation of mouse tissues established a widespread immunolocalization of Erg protein in endothelial cells and restricted expression in precartilage and hematopoietic tissues. Intriguingly, Erg is not expressed in any epithelial tissue including prostate epithelium, a common site of tumors with ERG rearrangements and unscheduled ERG expression. Further, use of two different monoclonal antibodies revealed that infiltrating lymphocytes that are occasionally seen in the prostate environment were positive for Fli-1, did not exhibit any Erg expression. These findings will further aid in investigations of Erg functions in normal and disease conditions. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4287. doi:10.1158/1538-7445.AM2011-4287
Antioxidants cause rapid expansion of human adipose-derived mesenchymal stem cells via CDK and CDK inhibitor regulation (2013)

Antioxidant treatment promotes entry of ADMSCs into the S phase by suppressing cyclin-dependent kinase inhibitors and results in rapid cell proliferation similar to that observed under hypoxic conditions.
Performance of multicarrier joint detection CDMA mobile communications systems (2002)

For future mobile communications, an appropriately chosen multiple access scheme is a critical issue. To support robust frequency planning, multi-operator scenarios, system coexistence and hierarchical cell structures, frequency division multiple access (FDMA) and multicarrier techniques are viable choices. Further multiple access schemes presently under discussion are code division multiple access (CDMA) and time division multiple access (TDMA). A mobile radio system concept deploying a hybrid frequency and time divided code division multiple access (F/T/CDMA) scheme with a multicarrier CDMA (MC-CDMA) component, called MC/JD-CDMA, is proposed and performance results for the uplink are presented. Attractive features of the proposed system concept are the possibility to flexibly offer voice and data services with different bit rates, soft capacity, as well as inherent frequency and interferer diversity.
Language model adaptation using dynamic marginals (1997)

A new method is presented to quickly adapt a given language model to local text characteristics. The basic approach is to choose the adaptive models as close as possible to the background estimates while constraining them to respect the locally estimated unigram probabilities. Several means are investigated to speed up the calculations. We measure both perplexity and word error rate to gauge the quality of our model.
From Mega-Cell to Giga-Cell Reservoir Simulation (2008)

Abstract For many oil & gas reservoirs, especially large reservoirs in the Middle East, the availability of vast amounts of seismic, geologic and dynamic reservoir data result in high resolution geological models. Because of the limitations of conventional reservoir simulator technologies, high resolution models are upscaled to flow simulation models by reducing the total number of cells from millions to a few hundred thousand. Flow simulators using upscaled reservoir properties produce average reservoir performance and often fall short of accurately predicting recovery. Realizing the limitations of the conventional simulators for the giant oil and gas reservoirs, parallel reservoir simulators have been developed. The first generation of parallel simulators increased the simulator capabilities by an order of magnitude — the result was that mega (million) cell simulation became a reality. Parallel computers, including PC Clusters, were successfully used to simulate large reservoirs with long production histories, using millions of cells. Mega-cell simulation helped recover additional oil and gas due to better understanding of reservoir heterogeneity. The speed of parallel hardware also helped, making many runs to address uncertainty possible. Despite the many benefits of parallel simulation technology for large reservoirs, the average cell size still remains in the order of hundreds of meters (m) for large reservoirs. To fully utilize the seismic data, smaller grid blocks of fifty m in length are required. This size of grid block results in billion (Giga) cell models for giant reservoirs. This is a two orders of magnitude increase from the mega-cell simulation. To simulate Giga-cell models in practical time, new innovations in the main components of the simulator, such as linear equation solvers, are essential. Also, the next generation pre- and post-processing tools are needed to build and analyze Giga-cell models in practical times. This paper describes the evolution of reservoir simulator technology, from Mega-Cell scale to a Giga-Cell scale, presenting current achievements, challenges and the road map for Giga-Cell Simulators.
Linear programmed thermal degradation mass spectrometry (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLinear Programmed Thermal Degradation Mass SpectrometryT. H. Risby and A. L. YergeyCite this: Anal. Chem. 1978, 50, 3, 326A–334APublication Date (Print):March 1, 1978Publication History Published online31 May 2012Published inissue 1 March 1978https://pubs.acs.org/doi/10.1021/ac50025a719https://doi.org/10.1021/ac50025a719research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reprogramming Urokinase into an Antibody-Recruiting Anticancer Agent (2011)

Synthetic compounds for controlling or creating human immunity have the potential to revolutionize disease treatment. Motivated by challenges in this arena, we report herein a strategy to target metastatic cancer cells for immune-mediated destruction by targeting the urokinase-type plasminogen activator receptor (uPAR). Urokinase-type plasminogen activator (uPA) and uPAR are overexpressed on the surfaces of a wide range of invasive cancer cells and are believed to contribute substantially to the migratory propensities of these cells. The key component of our approach is an antibody-recruiting molecule that targets the urokinase receptor (ARM-U). This bifunctional construct is formed by selectively, covalently attaching an antibody-binding small molecule to the active site of the urokinase enzyme. We demonstrate that ARM-U is capable of directing antibodies to the surfaces of target cancer cells and mediating both antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) against multiple human cancer cell lines. We believe that the reported strategy has the potential to inform novel treatment options for a variety of deadly, invasive cancers.
A Novel, Aqueous Surface Treatment To Thermally Stabilize High Resolution Positive Photoresist Images* (1986)

The paper describes a new approach to thermally stabilize the already imaged profile of high resolution positive photoresists such as ULTRAMAC" PR-914. ***XD-4000, an aqueous emulsion of a blend of fluorine-bearing compounds is spun on top of the developed, positive photoresist-imaged wafer, and baked. This allows the photoresist to withstand temperatures up to at least 175 deg. C. while essentially maintaining vertical edge profiles. Also, adverse effects of "outgassing" in harsh environments, ie., plasma and ion implant are greatly minimized by allowing the high resolution imaged photoresist to be post-baked at "elevated" temperatures. Another type of product that accomplishes the same effect is ***XD-4005, an aqueous emulsion of a high temperature-resistant polymer. While the exact mechanism is yet to be identified, it is postulated that absorption of the "polymeric" species into the "skin" of the imaged resist forms a temperature resistant "envelope", thereby allowing high resolution photoresists to also serve in a "high temperature" mode, without reticulation, or other adverse effects due to thermal degradation. SEM's are presented showing imaged ULTRAMAC" PR-914 and ULTRAMAC" **EPA-914 geometries coated with XD-4000 or XD-4005 and followed by plasma etched oxide,polysilicon and aluminum. Selectivity ratios are compared with and without the novel treatment and are shown to be significantly better with the treatment. The surface-treated photoresist for thermal resistance remains easily strippable in solvent-based or plasma media, unlike photoresists that have undergone "PRIST" or other gaseous thermal stabilization methods.
Surface‐Enhanced Raman Spectroscopy for Trace Arsenic Detection in Contaminated Water (2008)

Getting to the bottom of groundwater: The development of a reliable, portable, and simple-to-use device for detecting arsenic in groundwater is urgently needed in developing nations such as Bangladesh, where contaminated groundwater is at the root of a public health crisis. Toward this end, a highly sensitive platform utilizing surface-enhanced Raman spectroscopy (SERS, see picture) is used to quantitatively detect arsenate in water down to 1 ppb. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Anisotropic X-Ray Dark-Field Tomography: A Continuous Model and its Discretization (2016)

The x-ray dark-field signal measured in grating interferometers is anisotropic, depending on both the beam direction and the grating orientation with respect to the sample. We present a novel general closed-form, continuous forward model of the anisotropic dark-field signal. Furthermore, we derive a discretization using spherical harmonics, leading to a large-scale linear inverse problem. We present first experimental results of a wooden sample, demonstrating marked advantages over previous results, in particular, the resolution of multiple scattering directions in one volume element.
A Series of Function Blocking Antibodies against the αvβ3 Integrin Bind Allosteric to the Ligand Binding Site and Induce Ligand Dissociation (1998)

The alpha v beta 3 integrin plays a critical role in bone resorption, angiogenesis, and tumor cell invasion. A blockade of this receptor has therapeutic potential in osteoporosis, vascular restenosis, and cancer. In this report, we characterize the mechanism by which six monoclonal antibodies inhibit the function of alpha v beta 3. All six antibodies interact with a common site that is partially comprised of residues 164-202 within the beta 3 subunit. This domain is physically separate from the RGD binding site, and appears to regulate ligand binding allosterically. Thus, the blocking antibodies function, in part, by inducing the dissociation of ligand from alpha v beta 3. Although this family of antibodies is able to virtually abolish alpha v beta 3-mediated cell adhesion, they only block about one-half of soluble ligand binding to the integrin. This observation is consistent with the idea that two functionally distinct populations of alpha v beta 3 are present on the cell surface. The unique mechanism of action of these antibodies provides new insight in the structure-function relationships of alpha v beta 3, and also suggest that such antibodies are likely to behave differently than RGD mimetics if used as drugs.
G-SQL (2016)

A lot of real-life data are of graph nature. However, it is not until recently that business begins to exploit data's connectedness for business insights. On the other hand, RDBMSs are a mature technology for data management, but they are not for graph processing. Take graph traversal, a common graph operation for example, it heavily relies on a graph primitive that accesses a given node's neighborhood. We need to join tables following foreign keys to access the nodes in the neighborhood if an RDBMS is used to manage graph data. Graph exploration is a fundamental building block of many graph algorithms. But this simple operation is costly due to a large volume of I/O caused by the massive amount of table joins. In this paper, we present G-SQL, our effort toward the integration of a RDBMS and a native in-memory graph processing engine. G-SQL leverages the fast graph exploration capability provided by the graph engine to answer multi-way join queries. Meanwhile, it uses RDBMSs to provide mature data management functionalities, such as reliable data storage and additional data access methods. Specifically, G-SQL is a SQL dialect augmented with graph exploration functionalities and it dispatches query tasks to the in-memory graph engine and its underlying RDMBS. The G-SQL runtime coordinates the two query processors via a unified cost model to ensure the entire query is processed efficiently. Experimental results show that our approach greatly expands capabilities of RDBMs and delivers exceptional performance for SQL-graph hybrid queries.
Automatic detection and estimation of biparietal diameter from fetal ultrasonography (2011)

Fetal bi-parietal diameter (BPD) is known to provide a reliable estimate of gestational age (GA) of a fetus in the first half of pregnancy. In this paper, we present an automated method to identify and measure BPD from B-mode ultrasound images of fetal head. The method (a) automatically detects and places a region-of-interest on the head based on a prior work in our group (b) utilizes the concept of phase congruency for edge detection and (c) employs a cost function to identify the third ventricle inside the head (d) measures the BPD along the perpendicular bisector of occipital frontal diameter (OFD) from the outer rim of the cranium closer to the transducer to the inner rim of the cranium away from the transducer. The cost function is premised on the distribution of anatomical shape, size and presentation of the third ventricle in images that adhere to clinical guidelines describing the scan plane for BPD measurement. The OFD is assumed to lie along the third ventricle. The algorithm has been tested on 137 images acquired from four different scanners. Based on GA estimates and their bounds specified in Standard Obstetric Tables, the GA predictions from automated measurements are found to be within ±2SD of GA estimates from manual measurements by the operator and a second expert radiologist in 98% of the cases. The method described in this paper can also be adapted to assess the accuracy of the scan plane based on the presence/absence of the third ventricle.
Probabilistic characterization of sleep architecture: Home Based study on healthy volunteers (2016)

The quantification of sleep architecture has high clinical value for diagnostic purposes. While the clinical standard to assess sleep architecture is in-lab based polysomnography, higher ecological validity can be obtained with multiple sleep recordings at home. In this paper, we use a dataset composed of fifty sleep EEG recordings at home (10 per study participant for five participants) to analyze the sleep stage transition dynamics using Markov chain based modeling. The statistical analysis of the duration of continuous sleep stage bouts is also analyzed to identify the speed of transition between sleep stages. This analysis identified two types of NREM states characterized by fast and slow exit rates which from the EEG analysis appear to correspond to shallow and deep sleep respectively.
Direct Transfer Patterning of Electrically Small Antennas onto Three‐Dimensionally Contoured Substrates (2012)

A direct transfer patterning process is presented that allows metallic patterns to be stamped onto a contoured substrate. This process was used to make some of the most efficient electrically small antennas to date, while maintaining bandwidths approaching the physical limit.
Selective Oxidations Using Metal Nitro - Complexes (1985)

(1985). Selective Oxidations Using Metal Nitro - Complexes. Catalysis Reviews: Vol. 27, No. 1, pp. 1-28.