gebhart/patrepeval huggingface dataset:
Fluvoxamine treatment of obsessivecompulsive symptoms in schizophrenic patients: an add-on open study (1999)

Obsessive-Compulsive (OC) symptoms are observed in a substantial proportion of schizophrenic patients and pose a significant therapeutic challenge. Based on findings of the benefit of the anti-obsessive agent clomipramine, we designed an open-label study to examine the effect of adding the serotonin-selective reuptake inhibitor (SSRI) fluvoxamine to the ongoing antipsychotic regimen of schizo-obsessive patients. The study population consisted of ten neuroleptic-stabilized chronic schizophrenic patients with OC symptoms. Fluvoxamine (up to 150 mg/day) was added to the ongoing antipsychotic treatment, which remained unchanged for the entire 12-week trial period. The patients were evaluated before the trial and at weeks 1, 2, 4, 6, 8 and 12 (end point) with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Schedule for Assessment of Positive Symptoms and the Schedule for Assessment of Negative Symptoms. The results showed a significant improvement in obsessions (P < 0.02) (but not compulsions) and both positive (P < 0.01) and negative (P < 0.05) schizophrenic symptoms. By the end of the trial, three patients showed a more than 50% reduction in the Y-BOCS score, with complete amelioration of the OC symptoms in one of them. Three patients were dropped from the study during the first 4 weeks, two because of aggressiveness and one because of psychotic exacerbation. No exacerbation or new onset of extrapyramidal side-effects (EPS), as measured by the Barnes Akathisia Scale (BARS) and the Simpson-Angus Scale (SAS), was noted during the course of the trial and there were no other significant clinical side-effects of fluvoxamine addition. We conclude that fluvoxamine may be an effective adjunctive agent in some schizo-obsessive patients.
Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium (1997)

The factors that regulate the perpetuation and invasiveness of rheumatoid synovitis have been the subject of considerable inquiry, and the possibility that nonimmunologic defects can contribute to the disease has not been rigorously addressed. Using a mismatch detection system, we report that synovial tissue from the joints of severe chronic rheumatoid arthritis patients contain mutant p53 transcripts, which were not found in skin samples from the same patients or in joints of patients with osteoarthritis. Mutant p53 transcripts also were identified in synoviocytes cultured from rheumatoid joints. The predicted amino acid substitutions in p53 were identical or similar to those commonly observed in a variety of tumors and might influence growth and survival of rheumatoid synoviocytes. Thus, mutations in p53 and subsequent selection of the mutant cells may occur in the joints of patients as a consequence of inflammation and contribute to the pathogenesis of the disease.
Repurposing Drugs in Oncology (ReDO)—clarithromycin as an anti-cancer agent (2015)

Clarithromycin (CAM) is a well-known macrolide antibiotic available as a generic drug. CAM is traditionally used for many types of bacterial infections, treatment of Lyme disease and eradication of gastric infection with Helicobacter pylori. Extensive preclinical and clinical data demonstrate a potential role for CAM to treat various tumours in combination with conventional treatment. The mechanisms of action underlying the anti-tumour activity of CAM are multiple and include prolonged reduction of pro-inflammatory cytokines, autophagy inhibition, and anti-angiogenesis. Here, we present an overview of the current preclinical (in vitro and in vivo) and clinical evidence supporting the role of CAM in cancer. Overall these findings justify further research with CAM in many tumour types, with multiple myeloma, lymphoma, chronic myeloid leukaemia (CML), and lung cancer having the highest level of evidence. Finally, a series of proposals are being made to further investigate the use of CAM in clinical trials which offer the greatest prospect of clinical benefit to patients.
Detailed Studies of the Alkylation Sides of Pyridin‐2‐yl and 4,6‐Dimethylpyrimidin‐2‐yl‐cyanamides (2016)

Pyridin‐2‐yl‐ and 4,6‐dimethylpyrimidin‐2‐yl‐cyanamides entered into an alkylation reaction in the form of sodium salts. Pyridin‐2‐yl cyanamide 2 was alkylated at endo‐nitrogen atom of pyridine ring, while 4,6‐dimethylpyrimidin‐2‐yl cyanamide 1 was effectively alkylated at exo‐nitrogen atom of amino cyanamide group. The alkylation of cyanamides 1 and 2 with phenacylbromide gave the corresponding acetophenone derivatives. As a result of their intramolecular cyclization reactions 3‐(4,6‐dimethylpyrimidin‐2‐yl)‐5‐phenyloxazol‐2(3 H )‐imine in the case of cyanamide 1 and 2‐amino‐3‐benzoylimidazo[1,2‐ a ]pyridine in the case of cyanamide 2 were formed. The alkylated derivatives of pyridin‐2‐ylcyanamide 2 possess visible blue fluorescence with the main peak at 421 – 427 nm.
Présentation (2015)

Monsieur le Président de l’Université d’Avignon et des Pays de Vaucluse, Mesdames et Messieurs les membres de la Fondation de l’Université, Mesdames et Messieurs les représentants des corps constitués, Mesdames et Messieurs les membres du corps enseignant de l’Université, Chers Amis étudiants de l’Université, Mesdames et Messieurs, En ce jour de Fête de l’Université, et du 6e Gala de l’Orchidée, sous l’égide d’Allan Rochette, Vice-Président étudiant de l’Université, et organisé par l’Inter’As...
Real-time synchrotron powder X-ray diffraction study of the antisite defect formation during sub- and supercritical synthesis of LiFePO<sub>4</sub>and LiFe<sub>1−<i>x</i></sub>Mn<sub><i>x</i></sub>PO<sub>4</sub>nanoparticles (2011)

In situ synchrotron powder X-ray diffraction (PXRD) is used to study the formation of LiFePO 4 nanoparticles during hydrothermal synthesis from LiOH, H 3 PO 4 , and two different iron precursors, FeSO 4 and (NH 4 ) 2 Fe(SO 4 ) 2 . Furthermore, the synthesis of Li(Fe 1− x Mn x )PO 4 ( x = 0.25, 0.50 and 0.75) from LiOH, H 3 PO 4 and FeSO 4 /MnSO 4 is studied. The reactions involve an unknown intermediate phase, which is not the previously observed intermediate NH 4 FePO 4 ·H 2 O. The intermediate phase quickly transforms into LiFePO 4 and Li(Fe 1− x Mn x )PO 4 even at rather low temperatures. The presence of ammonium enhances the formation of LiFePO 4 , and it also leads to a significant reduction in the concentration of Li–Fe antisite defects. The in situ PXRD technique allows one to follow the influence of time, temperature and manganese doping on the antisite defect concentration, and it is shown that even under supercritical conditions a reaction time of several minutes is required to suppress the defects. This makes flow synthesis of defect-free LiFePO 4 and Li(Fe 1− x Mn x )PO 4 nanoparticles challenging.
SIGNet: Semantic Instance Aided Unsupervised 3D Geometry Perception (2019)

Unsupervised learning for geometric perception (depth, optical flow, etc.) is of great interest to autonomous systems. Recent works on unsupervised learning have made considerable progress on perceiving geometry; however, they usually ignore the coherence of objects and perform poorly under scenarios with dark and noisy environments. In contrast, supervised learning algorithms, which are robust, require large labeled geometric dataset. This paper introduces SIGNet, a novel framework that provides robust geometry perception without requiring geometrically informative labels. Specifically, SIGNet integrates semantic information to make depth and flow predictions consistent with objects and robust to low lighting conditions. SIGNet is shown to improve upon the state-of-the-art unsupervised learning for depth prediction by 30% (in squared relative error). In particular, SIGNet improves the dynamic object class performance by 39% in depth prediction and 29% in flow prediction. Our code will be made available at https://github.com/mengyuest/SIGNet
Cooperating Rings in <i>cis</i>-Stilbene Lead to an S<sub>0</sub>/S<sub>1</sub> Conical Intersection (1997)

Photoexcited cis-stilbene decays to the ground state on the femtosecond time scale, so fast that fluorescence is not generally observed and vibrational relaxation is incomplete. Decay can be accompanied by cis-trans isomerization about the double bond linking the two benzene rings and by electronic rearrangement to yield 4a,4b-dihydrophenanthrene (DHP). MMVB calculations suggest that there are several geometries (in addition to the perpendicular minimum) at which efficient decay can take place. In particular, a conical intersection has been documented along photocyclization reaction coordinate to DHP which may be reached with almost no barrier from a quinoid minimum. This intersection arises from interaction between the two benzene rings. Such a crossing is suggested in the recent experimental work of Yoshihara et al. (Petek, Il.; Yoshihara, K.; Fujiwara, Y.; Lin, Z.; Penn, J. H.; Frederick, J. H. J. Phys. Chem. 1990, 94, 7539-7543) and must form part of a new mechanism for the decay of this well-studied molecule.
Real-Time Action Detection in Video Surveillance using Sub-Action Descriptor with Multi-CNN (2017)

When we say a person is texting, can you tell the person is walking or sitting? Emphatically, no. In order to solve this incomplete representation problem, this paper presents a sub-action descriptor for detailed action detection. The sub-action descriptor consists of three levels: the posture, the locomotion, and the gesture level. The three levels give three sub-action categories for one action to address the representation problem. The proposed action detection model simultaneously localizes and recognizes the actions of multiple individuals in video surveillance using appearance-based temporal features with multi-CNN. The proposed approach achieved a mean average precision (mAP) of 76.6% at the frame-based and 83.5% at the video-based measurement on the new large-scale ICVL video surveillance dataset that the authors introduce and make available to the community with this paper. Extensive experiments on the benchmark KTH dataset demonstrate that the proposed approach achieved better performance, which in turn boosts the action recognition performance over the state-of-the-art. The action detection model can run at around 25 fps on the ICVL and more than 80 fps on the KTH dataset, which is suitable for real-time surveillance applications.
Magnetic properties of amorphous iron (1993)

Ultrasonic irradiation of iron pentacarbonyl was shown recently to result in the formation of fine (\ensuremath{\simeq}30 nm) amorphous, elemental-iron particles. We have measured the magnetic properties of an aggregate of these particles and find that they are soft ferromagnets with a Curie temperature in excess of 580 K. The exchange stiffness, as manifested through the coefficient of the ${\mathit{T}}^{3/2}$ temperature dependence in Bloch's law, is 30% of that of crystalline Fe. The low-temperature magnetization curves approach saturation as the inverse square root of applied field, which is characteristic of systems with random anisotropy fields. We argue that the results are consistent with the properties of an aggregate of amorphous Fe particles of nonspherical shape, giving rise to local shape anisotropy.
Comparison of the high-pressure and low-temperature structures of sulfuric acid (2002)

We have determined the high-pressure crystal-structure of sulfuric acid, including the positions of the hydrogen atoms, using a combination of single-crystal X-ray diffraction techniques and ab initio density functional calculations. Just above the onset of crystallization, at 0.7 GPa, we find that a previously unobserved monoclinic structure, with P21/c symmetry, is formed which is characterised by SO2(OH)2 tetrahedra interconnected by hydrogen bonds. In contrast to the low-temperature C2/c phase, the tetrahedra in the high-pressure crystal structure are no longer arranged in R44(16) hydrogen-bonded layers but, instead, they form chains where the hydrogen bonding adopts a R33(12) arrangement. A series of ab initio calculations indicates that this rearrangement of the molecules results in a relatively small reduction in the enthalpy (13.603 kJ mol−1) for the P21/c structure at 0.7 GPa.
A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis (2011)

The neurohormone melatonin is primarily involved in the regulation of circadian rhythms, but also acts as an antioxidant and anticarcinogenic agent, especially in breast cancer. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a widely known polyphenolic agent from red wine, which has been shown to exert antioxidant, anti-inflammatory and anticarcinogenic effects. The objective of this study was therefore to investigate the effects of melatonin in combination with resveratrol in a rat model of experimental mammary carcinogenesis. Female Sprague-Dawley rats aged 31 days were used in the experiment. Mammary carcinogenesis was induced by N-methyl-N-nitrosourea (NMU), which was administered in two intraperitoneal doses (50 mg/kg of body weight). Chemoprevention with resveratrol and melatonin started 2 weeks before the first dose of NMU and lasted until the end of the experiment. The basic parameters evaluated were: tumour incidence, latency period, tumour frequency per group and tumour volume. In addition, oestrogen receptors ERα and ERß, melatonin receptor MT1, proliferating cell nuclear antigen and vascular endothelial growth factor were determined by immunohistochemical staining. The combination of resveratrol and melatonin reduced tumour incidence by approximately 17% and significantly decreased the quantity of invasive and in-situ carcinomas. Food intake declined in the second and seventh weeks after the administration of carcinogen. Resveratrol in combination with melatonin returned food intake to the level of intact controls. Resveratrol in combination with melatonin has some protective effects on NMU-induced rodent breast cancer. Further studies are necessary to confirm these effects of this promising combination.
Febrile temperature leads to significant stiffening of <i>Plasmodium falciparum</i> parasitized erythrocytes (2008)

Parasitic infection with Plasmodium falciparum is responsible for the most severe form of human malaria in which patients suffer from periodic fever. It is well established that during intra-erythrocytic maturation of the parasite in the red blood cell (RBC), the RBC becomes significantly more cytoadhesive and less deformable; these and other biochemical factors together with human host factors such as compromised immune status are important contributors to the disease pathology. There is currently substantial interest in understanding the loss of RBC deformability due to P. falciparum infection, but few results are available concerning effects of febrile conditions or parasitization on RBC membrane rheology. Here, for the first time, we report rheology of the single, isolated RBC with and without P. falciparum merozoite invasion, spanning a range from room temperature to febrile conditions (41 degrees C), over all the stages of parasite maturation. As expected, stiffness increased with parasite maturation. Surprisingly, however, stiffness increased acutely with temperature on a scale of minutes, particularly in late trophozoite and schizont stages. This acute stiffening in late falciparum stages may contribute to fever-dependent pathological consequences in the microcirculation.
Synthesis of 5-Amino-4-cyanoformimidoylimidazoles and 5-Amino-4-cyanoimidazoles from Amidines (2006)

Imidazole and formimidoylimidazole derivatives have been synthesized in high yields by a reaction between amidine and a strong or weak base depending on reaction conditions and mainly on the nature of the base used to induced cyclization. All compounds have been characterized by spectroscopic data.
Refining Outdoor Photometric Stereo Based on Sky Model (2013)

We propose an outdoor photometric stereo method, which considers environmental lighting for improving the performance of surface normal estimation. In the previous methods, the sky illumination effect has been either assumed to be constant throughout the scene, or to be removed by pre-processing. This paper exploits a sky model which can derive the entire sky luminance from a sky zenith image; then, sky illumination effect on a surface can be correctly calculated by iteratively refining its normal direction. This paper also extends a two-source photometric stereo method by introducing RANSAC, so that the input images of this method can be taken in a day. Experimental results with real outdoor objects show the effectiveness of the method.
Thermal inactivation and injury of Bacillus stearothermophilus spores (1987)

Aqueous spore suspensions of Bacillus stearothermophilus ATCC 12980 were heated at different temperatures for various time intervals in a resistometer, spread plated on antibiotic assay medium supplemented with 0.1% soluble starch without (AAMS) or with (AAMS-S) 0.9% NaCl, and incubated at 55 degrees C unless otherwise indicated. Uninjured spores formed colonies on AAMS and AAMS-S; injured spores formed colonies only on AAMS. Values of D, the decimal reduction time (time required at a given temperature for destruction of 90% of the cells), when survivors were recovered on AAMS were 62.04, 18.00, 8.00, 3.33, and 1.05 min at 112.8, 115.6, 118.3, 121.1, and 123.9 degrees C, respectively. Recovery on AAMS-S resulted in reduced decimal reduction time. The computed z value (the temperature change which will alter the D value by a factor of 10) for spores recovered on AAMS was 8.3 degrees C; for spores recovered on AAMS-S, it was 7.6 degrees C. The rates of inactivation and injury were similar. Injury (judged by salt sensitivity) was a linear function of the heating temperature. At a heating temperature of less than or equal to 118.3 degrees C, spore injury was indicated by the curvilinear portion of the survival curve (judged by salt sensitivity), showing that injury occurred early in the thermal treatment as well as during logarithmic inactivation (reduced decimal reduction time). Heat-injured spores showed an increased sensitivity not only to 0.9% NaCl but also to other postprocessing environmental factors such as incubation temperatures, a pH of 6.6 for the medium, and anaerobiosis during incubation.
Synthese und katalytische Wirkung von dendritischen Diphosphan‐Metallkomplexen (1997)

Für Heck‐Reaktionen und Hydroformylierungen eignen sich Dendrimere, die mit Palladium (siehe 1 ) bzw. Rhodium beladen sind. Ein geeignetes Dendrimer mit 16 äußeren Bis(diphenylphosphinomethyl)amino‐Endgruppen ließ sich in einer Stufe durch Phosphinomethylierung eines käuflichen Polyaminodendrimers herstellen. magnified image
Aluminum Nitride Crystal Growth from an Al−N System at 6.0 GPa and 1800 °C (2010)

We report on hexagonal aluminum nitride (h-AlN) crystal growth in the Al−N system by means of AlN recrystallization in the field of a temperature gradient at 6 GPa and 1800 °C. A special setup for h-AlN growth using a multianvil apparatus has been developed, which allows the growth of colorless transparent h-AlN single crystals. Crystals exhibited two distinct morphological types. The first is short prismatic and platelet-like crystals with smooth faces and a size up to 0.4 mm. The second is skeleton crystals elongated along the [12̅10] direction and flattened along the (0001) plane with a size of up to 1.0 mm. Crystals have been characterized by scanning electron microscopy, Raman spectroscopy, and electron backscattered diffraction methods. The growth mechanism and main factors determining the crystal habit and growth rate in a high-pressure solution method are discussed. We also discuss the possibility of using the employed technique for cubic aluminum nitride (c-AlN) crystal growth.
In-Packet Network Coding for Effective Packet Wash and Packet Enrichment (2019)

Packets could be dropped completely in the current Internet if there is not enough buffer in the routers due to network congestion or packet error happens during the transmission. This practice causes re-transmissions of the packets under the reliable transmission protocols, which in-turn produces unwanted delay , reduces throughput, and wastes network resources. Recently, a new network service called Qualitative Communication suggests to avoid entire packet dropping, instead breaking the packet into smaller logical units (chunks). The network nodes (e.g. routers) could perform packet scrubbing on the packet with the granularity of chunks, such operation is named as Packet Wash. In this paper, we propose to apply random linear network coding on the chunks of the packet payload to enable the packet wash and packet enrichment in the network. The benefits of utilizing such packetization are discussed in the paper.
Multi-directional skip and direct modes design in bi-predictive slices for AVS2 standard (2014)

The second generation of Audio-video coding standard (AVS2) part 2 has obtained an outstanding compressing performance by a series of advanced technologies, e.g. flexible partition structure and high efficient prediction methods, etc. However, it is observed that there is still substantial motion information redundancy between spatial adjacent blocks. Therefore, this paper introduces a technique named Multi-directional SKIP and DIRECT modes (MDSD) to ameliorate SKIP/DIRECT mode to adapt to the features of block motion. Based on the study of the correlation between spatial adjacent blocks with the same or different motion models, a priority-based motion information derivation method is designed. A higher priority is assigned to the motion information of neighboring blocks with the same motion model as current block. Experiments in AVS2 reference software RD3.0 show improvements of up to 3.9% in BD rate reduction are achieved.
Elevated Triglycerides Correlate With Progression of Diabetic Neuropathy (2009)

In this cohort of participants with mild to moderate diabetic neuropathy, elevated triglycerides correlated with MFD loss independent of disease duration, age, diabetes control, or other variables. These data support the evolving concept that hyperlipidemia is instrumental in the progression of diabetic neuropathy.