gebhart/patrepeval huggingface dataset:
Ordering, distinctness, aggregation, partitioning and DQP optimization in sybase ASE 15 (2009)

The Sybase ASE RDBMS version 15 was subject to major enhancements, including semantic partitions and a full QP rewrite. The new ASE QP supports horizontal and vertical parallel processing over semantically partitioned tables, and many other modern QP techniques, as cost-based eager aggregation and cost-based join relocation DQP. In the new query optimizer, the ordering, distinctness, aggregation, partitioning, and DQP optimizations were based on a common framework: plan fragment equivalence classes and logical properties. Our main outcomes are a) an eager enforcement policy for ordering, partitioning and DQP location; b) a distinctness and aggregation optimization policy, opportunistically based on the eager ordering enforcement, and which has an optimization-time computational complexity similar to join processing; c) support for the user to force all of the above optimizer decisions, still guaranteeing a valid plan, based on the Abstract Plan technology. We describe the implementation of this solution in the ASE 15 optimizer. Finally, we give our experimental results: the generation of such complex plans comes with a small increase of the optimizer's SS size, hence within an acceptable optimization time; at execution, we have obtained performance improvements of orders of magnitude for some queries.
A Conditional E-coupon Service For Location-Aware Mobile Commerce (2005)

This paper presents the concept and theory of a conditional electronic coupon (CEC) service as an optimal wireless targeted advertising scheme to promote location-aware mobile commerce. The key idea of CEC service is to advertise stores conditionally, i.e., distributing e-coupons for a store to mobile customers only if the number of mobile customers requesting such e-coupons exceeds a threshold. Using the CEC service, mobile customers stand a good chance to obtain e-coupons from some local stores shortly before they go shopping there, and participating stores are guaranteed to make maximum extra profits in a statistical sense by issuing e-coupons.
Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity (2019)

High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. To facilitate the detection, molecular imaging, and sorting of stem cells, a green fluorescent probe based on the xanthene dye scaffold was recently developed. However, green dyes are less amenable to multicolor imaging because most commercial reagents are also green. Overcoming this limitation will enable the simultaneous tracking of multiple stem cell markers. Herein, we report the development of a red congener, red-AlDeSense. Through chemical tuning we were able to achieve excellent isoform selectivity and chemostability, a good turn on response, and enhanced cellular uptake and reactivity. Importantly, red-AlDeSense represents one of only a few turn-on sensors in the red region that use the d-PeT quenching mechanism. By employing red-AlDeSense and a green anti-CD44 antibody, we were able to demonstrate staining of these two stem cell markers is independent of one another in A549 lung adenocarcinoma cells.
Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells. (1994)

Tumor necrosis factor (TNF) binds two distinct cell surface receptors designated p60 and p80. Our previous studies indicate that a protein kinase from U-937 cells binds to and phosphorylates the p60 receptor. While the p80 receptor is phosphorylated in vivo, no association of a protein kinase has been described. We employed a fusion protein comprising of glutathione S-transferase and the cytoplasmic domain of the p80 receptor (GST-p80CD) to identify cellular proteins that might associate with this receptor. From 35S- and 32P-labeled cells, a protein of 59 kDa bound specifically to GST-p80CD. In vitro kinase reactions indicated that serine/threonine protein kinase activity associated with GST-p80CD and causes its phosphorylation. Additionally, a 59-kDa phosphoprotein was also identified after kinase reactions of proteins bound to GST-p80CD. This kinase activity required either Mg2+ or Mn2+ for optimal activity, and it phosphorylated myelin basic protein, histone H2B, and also the cytoplasmic domain of the p60 receptor. Treatment of cells with TNF increased the p80 receptor-associated kinase activity by 200%. In summary, our results provide evidence of a novel ligand-activated serine/threonine protein kinase that associates with the cytoplasmic domain of the p80 receptor and causes the phosphorylation of both forms of the TNF receptor. This p80 TNF receptor-associated protein and the associated kinase described here are referred to as p80-TRAP and p80-TRAK, respectively.
Low-Latency Low-Complexity Architectures for Viterbi Decoders (2009)

Look-ahead techniques are applied in the nonlinear add-compare-select unit for achieving high throughput in Viterbi decoders. Multiple steps of the binary trellis are combined into an equivalent one-step complex trellis in time sequence, which is referred to as the branch metric precomputation (BMP). As the look-ahead level increases, the BMP dominates the complexity and delay of the overall system architecture. This paper systematically proposes an optimal branch metric computation scheme with the minimal complexity and latency. The proof of its optimality is also given. This highly efficient scheme leads to a novel overall optimal BMP architecture for any look-ahead level. Furthermore, an alternative technique other than the look-ahead is proposed for reducing the latency at very low complexity cost. This alternative technique can be either applied in combination with the proposed architecture to achieve the lowest latency at a slight increase in complexity or used on its own for low complexity compared with other look-ahead-based architectures. Results show that the three proposed architectures can either reduce complexity by up to 84% or reduce the latency by up to 72.50%.
Coherent Passive Backscatter Communications Using Ambient Transmitters (2014)

A communications method is presented based on the backscatter modulation of incident radio frequency signals using low-complexity tags. The incident signals arise from digital television stations used as illuminators of opportunity. A receiver detects the tag using coherent processing algorithms similar to those used in passive radar, extending the detection range over published noncoherent techniques. This method enables shared use of the UHF television band for low-data-rate applications. While analyses suggest that rates exceeding 1 kbps might be achievable at 1 km range, experimental results demonstrate the challenges in designing and implementing such a system.
Synthesis of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to pertussis toxin (1992)

Type 14 is one of the common types isolated from patients of all ages with infections caused by Streptococcus pneumoniae. Its capsular polysaccharide (Pn14) is composed of a neutrally charged tetrasaccharide repeat unit. Pn14 does not elicit protective levels of antibodies in infants and children and is a less than optimal immunogen of the 23-valent vaccine for adults. Pertussis toxin (PT) is both a virulence factor and protective antigen of Bordetella pertussis: it is not soluble at neutral pH and forms insoluble complexes with acidic polysaccharides. Both Pn14 and PT are potential components of vaccines for infants and children. Accordingly, a synthetic scheme was devised to prepare a conjugate of Pn14 and PT. An adipic acid hydrazide derivative of Pn14 was bound to PT at pH 3.9 by carbodiimide-mediated condensation. The conjugation procedure inactivated the PT as assayed by CHO cell and histamine-sensitizing activity. The Pn14-PT conjugate elicited antibodies in mice to Pn14 at levels estimated to be protective in humans and elicited neutralizing antibodies to PT. We plan to evaluate Pn14-PT clinically.
Three-dimensional photoacoustic imaging by sparse-array detection and iterative image reconstruction (2008)

Photoacoustic imaging (PAI) has the potential to acquire 3-D optical images at high speed. Attempts at 3-D photoacoustic imaging have used a dense 2-D array of ultrasound detectors or have densely scanned a single detector on a 2-D surface. The former approach is costly and complicated to realize, while the latter is inherently slow. We present a different approach based on a sparse 2-D array of detector elements and an iterative reconstruction algorithm. This approach has the potential for fast image acquisition, since no mechanical scanning is required, and for simple and compact construction due to the smaller number of detector elements. We obtained spatial sensitivity maps of the sparse array and used them to optimize the image reconstruction algorithm. We then validated the method on phantoms containing 3-D distributions of optically absorbing point sources. Reconstruction of the point sources from the time-domain signals resulted in images with good contrast and accurate localization (< or =1 mm error). Image acquisition time was 1 s. The results suggest that 3-D PAI with a sparse array of detector elements is a viable approach. Furthermore, the rapid acquisition speed indicates the possibility of high frame rate 3-D PAI.
Complementary Magnetic Tunnel Junction Logic (2014)

This brief proposes and analyzes a novel logic family composed solely of magnetic tunnel junctions (MTJs) to form complimentary pull-up and pull-down networks. This logic family solves the challenge of direct cascading in spintronic logic circuits while also providing non-volatile data storage. The increased logic density possible with complementary MTJs coupled with a charge pulse switching mechanism driven by ferromagnet polarization permits highly efficient logical computation. Furthermore, the presence of non-volatile memory within the logic structure provides a feasible hardware for non-von Neumann computer architectures.
Ionic Liquid Enabled FeS<sub>2</sub> for High‐Energy‐Density Lithium‐Ion Batteries (2014)

High-energy-density FeS2 cathodes en-abled by a bis(trifluoromethanesulfonyl)imide (TFSI-) anion-based room temperature ionic liquid (RTIL) electrolyte are demonstrated. A TFSI-based ionic liquid (IL) significantly mitigates polysulfide dissolution, and therefore the parasitic redox shuttle mechanism, that plagues sulfur-based electrode chemistries. FeS2 stabilization with a TFSI(-) -based IL results in one of the highest energy density cathodes, 542 W h kg(-1) (normalized to cathode composite mass), reported to date.
Ex Vivo Expansion of Human Pancreatic Endocrine Cells1 (1997)

Cell transplantation as a therapy for type 1 diabetes is facilitated by ex vivo cell expansion of pancreatic beta-cells without loss of differentiative characteristics. The aim of this study was to determine the optimal conditions for in vitro growth of functional human pancreatic endocrine tissue. We examined the mitogenicity of matrixes from a variety of cell lines; proliferation was greater in cells growing on matrixes from bladder carcinoma cell lines, especially in monolayers grown on matrix from the human cell line HTB-9. After 14-day culture, there was a more than 100-fold proliferative increase, which was augmented to a more than 200-fold when hepatocyte growth factor/scatter factor was added; however, hepatocyte growth factor/scatter factor induced a rapid decrease in insulin content. Without the growth factor, fetal cell monolayers expanded 4-fold with no insulin loss; however, after 12-fold expansion, the insulin levels decreased to 40% of those in unexpanded cells. Adult islet cells expanded 3-fold without insulin loss. After 5-fold expansion, insulin levels decreased by 25% compared to those in free floating islets while retaining a normal response to secretagogues. Together, these results indicate that HTB-9 matrix provides the best stimulatory effect on replication of human endocrine cells, with little loss of in vitro function.
Selective inhibition of bacterial topoisomerase I by alkynyl-bisbenzimidazoles (2014)

Hoechst dyes are well known DNA binders that non-selectively inhibit the function of mammalian topoisomerase I and II. Herein, we show that Hoechst 33258 based bisbenzimidazoles (DPA 151-154), containing a terminal alkyne, are effective and selective inhibitors of E. coli. topoisomerase I. These bisbenzimidazoles displayed topoisomerase I inhibition much better than Hoechst 33342 or Hoechst 33258 with IC50 values in the range of 2.47-6.63 μM. Bisbenzimidazoles DPA 151-154 also display selective inhibition of E. coli. topoisomerase I over DNA gyrase and Human topoisomerases I and II, and effectively inhibit bacterial growth.
A Recyclable Chiral Ru Catalyst for Enantioselective Olefin Metathesis. Efficient Catalytic Asymmetric Ring-Opening/Cross Metathesis in Air [<i>J. Am. Chem. Soc.</i> <b>2002</b>, <i>124</i>, 4954−4955]. (2003)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionA Recyclable Chiral Ru Catalyst for Enantioselective Olefin Metathesis. Efficient Catalytic Asymmetric Ring-Opening/Cross Metathesis in Air [J. Am. Chem. Soc.2002, 124, 4954−4955].Joshua J. Van Veldhuizen, Steven B. Garber, Jason S. Kingsbury, and Amir H. HoveydaCite this: J. Am. Chem. Soc. 2003, 125, 41, 12666Publication Date (Web):September 13, 2003Publication History Published online13 September 2003Published inissue 1 October 2003https://doi.org/10.1021/ja033454fCopyright © 2003 American Chemical SocietyRequest reuse permissions This publication is free to access through this site. Learn MoreArticle Views981Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (16 KB) Get e-Alertsclose Get e-Alerts
Synthesis, characterization, and reactivity of lead(II) glycolate complexes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, characterization, and reactivity of lead(II) glycolate complexesClive D. Chandler, Mark J. Hampden-Smith, and Eileen N. DueslerCite this: Inorg. Chem. 1992, 31, 23, 4891–4893Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ic00049a032https://doi.org/10.1021/ic00049a032research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Unitized Regenerative Fuel Cell System Model Development (2003)

A Unitized Regenerative Fuel Cell (URFC) Energy Storage System is being developed at the NASA Glenn Research Center. This URFC system is unique in that it uses the surface area of the hydrogen and oxygen storage tanks as radiating heat surfaces for overall thermal control of the system. The tank surfaces also play an important role in the temperature control of regenerative gas dryers/humidifiers used to dry the hydrogen and oxygen gases produced by electrolysis during the charging and also used to humidify the hydrogen and oxygen gases used by fuel cell during the discharging of the URFCS. A bi- directional pressure controller is used to control the pressure of the oxygen and hydrogen gas inside the URFC stack during both charging and discharging of the URFC system. A water storage accumulator is used to store water reactant and control water pressure inside the URFC stack.
Novel Branched Poly(Ethylenimine)−Cholesterol Water-Soluble Lipopolymers for Gene Delivery (2002)

A novel water-soluble lipopolymer was synthesized by linking cholesteryl chloroformate to the secondary amino groups of branched poly(ethylenimine) (PEI) of 1,800 and 10,000 Da. Conjugation through PEI secondary amines gives this newly synthesized lipopolymer (abbreviated as PEI-Chol) special advantage over our previously synthesized lipopolymers, which utilized the primary amino groups for conjugation, as the primary amino groups have a significant role in DNA condensation. Also, significantly, only one cholesterol molecule was grafted onto each PEI molecule (confirmed by (1)H NMR and MALDI-TOF mass spectrometry), leaving enough space for the steric interactions of the PEI's primary amines with the DNA. The PEI-Chol lipopolymer was characterized for the critical micellar concentration (cmc), buffer capacity, DNA condensation (by band retardation and circular dichroism), in vitro transfection efficiency, and cell viability. The cmcs of PEI-Chol 1,800 and PEI-Chol 10,000 were 496.6 and 1,330.5 microg/mL, respectively. The acid-base titration indicated high buffering capacity of the polymers around the pH range of 5-7, which indicated their potential for buffering in the acidic pH environment of the endosomes. The band retardation studies indicated that efficient condensation of the plasmid DNA could be achieved using these lipopolymers. The circular dichroism spectra indicated a change in DNA conformation and adoption of lower energy state upon condensation with these lipopolymers when an N/P ratio of 2.5/1 or above was formulated. The mean particle size of these complexes was in the range 110-205 nm, except for the complexes prepared using PEI of 1,800 Da, which had a mean particle size of 384 +/- 300 nm. The zeta potential of DNA complexes prepared using PEI-Chol 1,800, PEI-Chol 10,000 and PEI of 1,800, 10,000, and 25,000 Da at an N/P ratio of 15/1 was in the range 23-30 mV and was dependent on the N/P ratios. The in vitro transfection of PEI-Chol/pCMS-EGFP complexes in Jurkat cells showed high levels of expressed Green Fluorescent Protein (GFP) with little toxicity as determined by flow cytometry. These novel water-soluble lipopolymers provided good transfection efficiency with other desirable characteristics such as water solubility, free primary amino groups for efficient DNA condensation and high buffer capacity that indicated the possibility of efficient endosomal release.
Recent advances and future trends of InAs/GaSb superlattice for very long wavelength infrared focal plane arrays (FPAs) (2002)

TypeII GaSb-InAs superlattices are an alternative to HgCdTe for the strategic windows of 3-5/spl mu/m, 8-12 /spl mu/m, as well as longer wavelengths. In this talk, I will present our recent results and future trends of the InAs-GaSb photodetector with a cut-off wavelength up to 26 /spl mu/m.
Electromechanical Tuning of Piecewise Stiffness and Damping for Long-Range and High-Precision Piezoelectric Ultrasonic Transducers (2020)

This paper presents a novel technique for quickly deactivating piezo-electric micromachined ultrasonic transducers (PMUT) in order to increase their potential for acoustic imaging. The proposed PMUT is anchored by four arms and surrounded by two mechanical dampers. The dampers are moved using electrostatic actuators in order to come into contact with the PMUT. By doing so, the resonant frequency of the PMUT can be shifted and the amplitude at the working frequency can be reduced. Measurement results show that this technique can effectively dampen the displacement of the PMUT.
Targeting a Hidden Enemy: Pyriproxyfen Autodissemination Strategy for the Control of the Container Mosquito Aedes albopictus in Cryptic Habitats (2016)

The autodissemination station effectively exploits the oviposition behavior of wild gravid females to deliver pyriproxyfen to targeted oviposition habitats. Although the pupal mortality in cryptic cups was relatively lower than expected for the effective vector control. Autodissemination approach may be a suitable supporting tool to manage Ae. albopictus immatures in the cryptic habitats those are less accessible to conventional larvicidal sprays.
Robust and Efficient Cartesian Mesh Generation for Component-Based Geometry (1998)

This work documents a new method for rapid and robust Cartesian mesh generation for component-based geometry. The new algorithm adopts a novel strategy that first intersects the components to extract the wetted surface before proceeding with volume mesh generation in a second phase. The intersection scheme is based on a robust geometry engine that uses adaptive precision arithmetic and automatically and consistently handles geometric degenerades with an algorithmic tie-breaking routine. The intersection procedure has worst-case computational complexity of O(N log N) and is demonstrated on test cases with up to 121 overlapping and intersecting components, including a variety of geometric degeneracies. The volume mesh generation takes the intersected surface triangulation as input and generates the mesh through cell division of an initially uniform coarse grid. In refining hexagonal cells to resolve the geometry, the new approach preserves the ability to directionally divide cells that are well aligned with local geometry. The mesh generation scheme has linear asymptotic complexity with memory requirements that total approximately 14-17 words/cell. The mesh generation speed is approximately 10 6 cells/minute on a typical engineering workstation
High-speed optical frequency modulation in a monolithically integrated widely-tunable laser-phase modulator (2004)

A factor of ten improvement of modulation bandwidth, from 2 GHz to 20 GHz, is demonstrated using phase modulator monolithically integrated to a semiconductor amplifier and a widely-tunable SG-DBR (sampled-grating distributed Bragg reflector) laser. This is achieved by generating optical frequency modulation converted to intensity modulation in an optical ASE filter.