gebhart/patrepeval huggingface dataset:
Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview (2019)

Nowadays, the oral use of probiotics is widespread. However, the safety profile with the use of live probiotics is still a matter of debate. Main risks include: Cases of systemic infections due to translocation, particularly in vulnerable patients and pediatric populations; acquisition of antibiotic resistance genes; or interference with gut colonization in neonates. To avoid these risks, there is an increasing interest in non-viable microorganisms or microbial cell extracts to be used as probiotics, mainly heat-killed (including tyndallized) probiotic bacteria (lactic acid bacteria and bifidobacteria). Heat-treated probiotic cells, cell-free supernatants, and purified key components are able to confer beneficial effects, mainly immunomodulatory effects, protection against enteropathogens, and maintenance of intestinal barrier integrity. At the clinical level, products containing tyndallized probiotic strains have had a role in gastrointestinal diseases, including bloating and infantile coli-in combination with mucosal protectors-and diarrhea. Heat-inactivated probiotics could also have a role in the management of dermatological or respiratory allergic diseases. The reviewed data indicate that heat-killed bacteria or their fractions or purified components have key probiotic effects, with advantages versus live probiotics (mainly their safety profile), positioning them as interesting strategies for the management of common prevalent conditions in a wide variety of patients´ characteristics.
Digitally trimmable MOS-current mirrors for high precision applications (2002)

A high accuracy digitally trimmable MOS transistor structure is proposed, and its working principle is experimentally verified. Experimental results on devices fabricated using a standard 3-/spl mu/m p-well CMOS process show that the gain of current mirrors using the proposed structure can be trimmed with an accuracy of better than 0.1%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Proteome analysis of extracellular proteins regulated by the las and rhl quorum sensing systems in Pseudomonas aeruginosa PAO1 (2003)

The las and rhl quorum sensing (QS) systems regulate the expression of several genes in response to cell density changes in Pseudomonas aeruginosa. Many of these genes encode surface-associated or secreted virulence factors. Proteins from stationary phase culture supernatants were collected from wild-type and P. aeruginosa PAO1 mutants deficient in one or more of the lasRI, rhlRI and vfr genes and analysed using two-dimensional gel electrophoresis. All mutants released significantly lower amounts of protein than the wild-type. Protein spot patterns from each strain were compared using image analysis and visible spot differences were identified using mass spectrometry. Several previously unknown QS-regulated proteins were characterized, including an aminopeptidase (PA2939), an endoproteinase (PrpL) and a unique 'hypothetical' protein (PA0572), which could not be detected in the culture supernatants of Deltalas mutants, although they were unaffected in Deltarhl mutants. Chitin-binding protein (CbpD) and a hypothetical protein (PA4944) with similarity to host factor I (HF-I) could not be detected when any of the lasRI or rhlRI genes were disrupted. Fourteen proteins were present at significantly greater levels in the culture supernatants of QS mutants, suggesting that QS may also negatively control the expression of some genes. Increased levels of two-partner secretion exoproteins (PA0041 and PA4625) were observed and may be linked to increased stability of their cognate transporters in a QS-defective background. Known QS-regulated extracellular proteins, including elastase (lasB), LasA protease (lasA) and alkaline metalloproteinase (aprA) were also detected.
Characterization of Aplysia Enticin and Temptin, Two Novel Water-borne Protein Pheromones That Act in Concert with Attractin to Stimulate Mate Attraction (2004)

Mate attraction in Aplysia involves a long-distance water-borne signal (attractin) that is released during egg laying. Other pheromones are predicted to be released during egg laying that act in concert with albumen gland attractin to stimulate attraction, but their identities are unknown. To identify other candidate water-borne pheromones, we employed differential library screening of an albumen gland cDNA library, Northern blot analysis, purification, characterization, cloning, and expression of albumen gland proteins, matrix-assisted laser desorption ionization mass spectrometry, pheromone secretion assays, behavioral bioassays, immunolocalization studies, and comparative genomics. Four genes, Alb-23, Alb-24, Alb-69, and Alb-172, were highly expressed in Aplysia californica albumen glands and encoded novel proteins. The products of the Alb-24 ("enticin") and Alb-172 ("temptin") precursors were soluble and highly abundant in albumen gland extracts, whereas Alb-23 and Alb-69 were membrane-associated proteins. A comparative analysis showed that the predicted Aplysia brasiliana enticin and temptin proteins were 90 and 91% identical, respectively, to their A. californica homologs. T-maze attraction bioassay studies have previously demonstrated that egg cordons alone are attractive to Aplysia but that attractin alone is not. In the present study, however, the combination of attractin, enticin, and temptin was found to be significantly attractive to potential mates and doubled the number of animals attracted to this stimulus compared with control animals. The combined data strongly suggest that enticin and temptin are novel candidate water-borne protein pheromones that act in concert with attractin to attract Aplysia to form and maintain egglaying and mating aggregations.
An authentication and Ballot layout attack against an optical scan voting terminal (2007)

Recently, two e-voting technologies have been introduced and used extensively in election procedures: direct recording electronic (DRE) systems and optical scanners. The latter are typically deemed safer as many recent security reports have discovered substantial vulnerabilities in a variety of DRE systems. In this paper we present an attack against the Diebold Accuvote optical scan voting terminal (AV-OS). Previously known attacks direct to the AV-OS required physical access to the memory card and use of difficult to find hardware (card reader/writer). Our attack bypasses these issues by using the serial port of the AV-OS terminal and reverse engineering the communication protocol, in essence, using the terminal itself as a reader/writer. Our analysis is based solely on reverse-engineering. We demonstrate how an attacker can exploit the serious security vulnerability of weak (non-cryptographic) authentication properties of the terminal. The attack payload delivers a tampered ballot layout that, depending on the scenario, allows swapping of candidate votes, neutralizing votes, or even shifting votes from one candidate to another. 1
Auxin-Enhanced Glucan Autohydrolysis in Maize Coleoptile Cell Walls (1991)

Cell walls isolated from auxin-pretreated maize (Zea mays L.) coleoptile segments were assayed to disclose evidence for the existence of enhanced autolysis. To improve the sensitivity of the measurements and to facilitate kinetic analysis, isolated cell walls were consolidated within a small column, and the autolysis rate was directly determined from the sugar content of the effluent. This protocol revealed that the maximum rate of autohydrolysis of walls prepared from segments occurs within the first 2 hours and a steady decline commences almost immediately. Walls from indoleacetic acid pretreated segments (0.5-4 hours) released sugar at a higher rate initially (110-125% of controls) and the enhanced rate of autolysis continued for 6 to 8 hours, but then it became equivalent to that of the controls. Pretreatment of the segments at acidic pH had no effect on the measurable rates of autolysis. The (1-->3), (1-->4)-beta-d-glucan content of the walls and the extractable glucanase activities support the hypothesis that temporal enhancement of autohydrolysis is a function of auxin on enzyme activity. The progressive decline in autolysis during prolonged incubations is consistent with the decrease in the quantity of the beta-d-glucan in the wall. The relationship between glucan content and autolysis rate is supported by the observation that while glucose pretreatment of segments had only a small effect on initial autolysis rates, the presence of the sugar during pretreatment served to extend the interval over which higher rates of autolysis could be sustained. The results demonstrate that autolysis is related to auxin-induced wall metabolism in maize coleoptiles.
The Defence Supply Naval Shipbuilding Panel, 1955-1965 (1992)

The Northern Mariner Thus, before the vessels could be built and equipped there was (and, no doubt, still is) a mass of contractual endeavour to be undertaken. By statute this was then the province of the Department of Defence Production (DDP)--and, especially, its Shipbuilding Branch. Here it may be noted that in those days the navy was also responsible for the work of the Naval Central Drawing Office (NCDO), which produced the working drawings for the various destroyer escorts and thus had a further involvement in the contractual negotiations. As well, of course, it was the Department of National Defence (DND) which in the ultimate outcome had to foot the bill. Thus the navy had also to respond to the overall control of the Minister of National Defence, exercised through various ADM's and their staffs. The general comment of these latter was to the effect that "everything is done much better by the Air Force." After unification, when to some extent we had a clearer understanding, many of us had some doubts about this statement. Finally, brooding from afar over all this-invariably unhappily-were the powerful gurus of Treasury Board.
Pole placement by performance criterion modification (1988)

A procedure is presented that modifies the state weighting matrix Q and introduces a degree of relative stability into the original performance criterion to shape the resulting optimal dynamics by positioning the closed-loop eigenvalues along the real axis of the optimal system in the linear-quadratic regulator problem. It is based on the results of the algebraic Riccati equation (ARE) which establish the invariance of certain eigenspaces of the associated Hamiltonian matrix with respect to certain perturbations of Q and the degree of relative stability.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Intraoperative localization of colorectal tumors in the early stages using a marking clip detector system (1999)

In laparoscopic colectomy the identification of the site of a tumor is often difficult. The topical injection of india ink or blue dye by preoperative colonoscopy is the most prevalent method to mark the tumor site; however, such a procedure also includes the intrinsic danger of possibly injecting dye into the peritoneal cavity. In addition, the injected marker may also spread so widely that the intended site may become obscure. A marking clip detector system was used to detect metallic marking clips in the luminal side that had been applied to the mucosa adjacent to the lesion during the course of preoperative colonoscopy. This method was able to identify the marked site in 40 percent of cases in which only one clip was applied to the mucosa. However, when the lesion sites were marked with two or three clips, then the detection rate increased to 100 percent. Based on our findings, this procedure was found to be a safe and reliable method for identifying lesions during laparoscopic-assisted colectomy.
Nanoelectronic Programmable Synapses Based on Phase Change Materials for Brain-Inspired Computing (2011)

Brain-inspired computing is an emerging field, which aims to extend the capabilities of information technology beyond digital logic. A compact nanoscale device, emulating biological synapses, is needed as the building block for brain-like computational systems. Here, we report a new nanoscale electronic synapse based on technologically mature phase change materials employed in optical data storage and nonvolatile memory applications. We utilize continuous resistance transitions in phase change materials to mimic the analog nature of biological synapses, enabling the implementation of a synaptic learning rule. We demonstrate different forms of spike-timing-dependent plasticity using the same nanoscale synapse with picojoule level energy consumption.
Effect of switch duty ratio on the performance of class E amplifiers and frequency multipliers (1998)

Class E circuits have usually been analyzed for particular values of the switch duty ratio. This paper presents a systematic analysis of the effects of the switch duty ratio on the design values and performance of Class E amplifiers and frequency multipliers, for various values of the output network Q. Some new and promising design possibilities are pointed out, especially for class E frequency multipliers operating at low Q values.
Adaptive and quality 3D meshing from imaging data (2003)

This paper presents an algorithm to extract adaptive and quality 3D meshes directly from volumetric imaging data - primarily Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). The extracted tetrahedral and hexahedral meshes are extensively used in finite element simulations. Our comprehensive approach combines bilateral and anisotropic (feature specific) diffusion filtering, with contour spectrum based, isosurface and interval volume selection. Next, a top-down octree subdivision coupled with the dual contouring method is used to rapidly extract adaptive 3D finite element meshes from volumetric imaging data. The main contributions are extending the dual contouring method to crack free interval volume tetrahedralization and hexahedralization with feature sensitive adaptation. Compared to other tetrahedral extraction methods from imaging data, our method generates better quality adaptive 3D meshes without hanging nodes. Our method has the properties of crack prevention and feature sensitivity.
Improving SPARQL query performance with algebraic expression tree based caching and entity caching (2012)

To obtain comparable high query performance with relational databases, diverse database technologies have to be adapted to confront the complexity posed by both Resource Description Framework (RDF) data and SPARQL query. Database caching is one of such technologies that improves the performance of database with reasonable space expense based on the spatial/temporal/semantic locality principle. However, existing caching schemes exploited in RDF stores are found to be dysfunctional for complex query semantics. Although semantic caching approaches work effectively in this case, little work has been done in this area. In this paper, we try to improve SPARQL query performance with semantic caching approaches, i.e., SPARQL algebraic expression tree (AET) based caching and entity caching. Successive queries with multiple identical sub-queries and star-shaped joins can be efficiently evaluated with these two approaches. The approaches are implemented on a two-level-storage structure. The main memory stores the most frequently accessed cache items, and items swapped out are stored on the disk for future possible reuse. Evaluation results on three mainstream RDF benchmarks illustrate the effectiveness and efficiency of our approaches. Comparisons with previous research are also provided.
Accurate Oxidation Potentials of 40 Benzene and Biphenyl Derivatives with Heteroatom Substituents (2014)

The redox equilibrium method was used to determine accurate oxidation potentials in acetonitrile for 40 heteroatom-substituted compounds. These include methoxy-substituted benzenes and biphenyls, aromatic amines, and substituted acetanilides. The redox equilibrium method allowed oxidation potentials to be determined with high precision (≤ ±6 mV). Whereas most of the relative oxidation potentials follow well-established chemical trends, interestingly, the oxidation potentials of substituted N-methylacetanilides were found to be higher than those of the corresponding acetanilides. Density functional theory calculations provided insight into the origin of these surprising results in terms of the preferred conformations of the amides versus their cation radicals.
A Probabilistic Approach for Forecasting the Allowable Current of Oil-Immersed Transformers (2018)

The overall growth of electrical energy consumption and the spread of distributed generation pose severe problems to system planners and operators, mainly due to the difficulties in expanding and upgrading electrical distribution systems. These problems can be partially overcome through the smart operation of power system components. In particular, under the new smart grid paradigm, lines and transformers could be loaded beyond their nameplate rating in favorable thermal conditions, without loss of rated life or breakdown. This paper deals with the loading of oil-immersed distribution transformers, and it proposes a probabilistic approach based on the monitoring of electrical and environmental conditions. The approach consists in forecasting the predictive distribution of the transformer dynamic rating, and then in forecasting the transformer allowable current. The probabilistic approach takes into account the unavoidable uncertainties involved in the thermal modeling of the transformer; indeed, it selects the allowable current through an index that takes into account both the probability of the allowable current to be higher than the predicted dynamic rating and the corresponding expected load curtailment. Numerical applications are performed on real data to evaluate the effectiveness of the proposed procedure.
Influence of plasma-activated compounds on melanogenesis and tyrosinase activity (2016)

Many organic chemists around the world synthesize medicinal compounds or extract multiple compounds from plants in order to increase the activity and quality of medicines. In this work, we synthesized new eugenol derivatives (ED) and then treated them with an N2 feeding gas atmospheric pressure plasma jet (APPJ) to increase their utility. We studied the tyrosinase-inhibition activity (activity test) and structural changes (circular dichroism) of tyrosinase with ED and plasma activated eugenol derivatives (PAED) in a cell-free environment. Later, we used docking studies to determine the possible interaction sites of ED and PAED compounds with tyrosinase enzyme. Moreover, we studied the possible effect of ED and PAED on melanin synthesis and its mechanism in melanoma (B16F10) cells. Additionally, we investigated the structural changes that occurred in activated ED after plasma treatment using nuclear magnetic resonance (NMR). Hence, this study provides a new perspective on PAED for the field of plasma medicine.
Clinical trial on the efficacy and tolerability of a novel low-volume mesalamine foam (2×1g 5-ASA/30ml) vs mesalamine foam (2×1g 5-ASA/60ml) in active ulcerative proctitis or proctosigmoiditis (2006)

Lietuvos sveikatos mokslų universitetas (302536989)
Composition and bandgap control in Cu(In,Ga)Se<sub>2</sub>-based absorbers formed by reaction of metal precursors (2014)

The control of composition and bandgap in chalcopyrite thin-film absorber layers formed by a metal precursor reaction is addressed. Two processes using reaction with either H2Se or H2S as the final step of a three-step reaction process were compared as follows: a three-step H2Se/Ar/H2S reaction and a three-step H2Se/Ar/H2Se reaction. In both processes, significant Ga homogenization was obtained during the second-step Ar anneal, but the third-step selenization resulted in Ga depletion near the Cu(InGa)Se2 surface, whereas the third-step sulfization did not. Solar cells were fabricated using absorbers formed using each method, and the surface Ga depletion significantly affected device performances. The solar cell incorporating the sulfization yielded a better device performance, with an efficiency of 14.4% (without an anti-reflection layer) and an open-circuit voltage of 609 mV. The bandgap control in the metal precursor reaction is discussed in conjunction with the device behavior. Copyright © 2014 John Wiley & Sons, Ltd.
HIV & immune reconstitution inflammatory syndrome (IRIS) (2011)

Antiretroviral therapy (ART) initiation in HIV-infected patients leads to recovery of CD4+T cell numbers and restoration of protective immune responses against a wide variety of pathogens, resulting in reduction in the frequency of opportunistic infections and prolonged survival. However, in a subset of patients, dysregulated immune response after initiation of ART leads to the phenomenon of immune reconstitution inflammatory syndrome (IRIS). The hallmark of the syndrome is paradoxical worsening of an existing infection or disease process or appearance of a new infection/disease process soon after initiation of therapy. The overall incidence of IRIS is unknown, but is dependent on the population studied and the burden of underlying opportunistic infections. The immunopathogenesis of the syndrome is unclear and appears to be result of unbalanced reconstitution of effector and regulatory T-cells, leading to exuberant inflammatory response in patients receiving ART. Biomarkers, including interferon-γ (INF-γ), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and inter leukin (IL)-2, 6 and 7, are subject of intense investigation at present. The commonest forms of IRIS are associated with mycobacterial infections, fungi and herpes viruses. Majority of patients with IRIS have a self-limiting disease course. ART is usually continued and treatment for the associated condition optimized. The overall mortality associated with IRIS is low; however, patients with central nervous system involvement with raised intracranial pressures in cryptococcal and tubercular meningitis, and respiratory failure due to acute respiratory distress syndrome (ARDS) have poor prognosis and require aggressive management including corticosteroids. Paradigm shifts in management of HIV with earlier initiation of ART is expected to decrease the burden of IRIS in developed countries; however, with enhanced rollout of ART in recent years and the enormous burden of opportunistic infections in developing countries like India, IRIS is likely to remain an area of major concern.
Peru : reforming the pension system (1995)

This paper identifies the main areas of pension reform that Peru should address in order to complement its optional capitalization scheme introduced in 1992. The guiding principle of the remaining changes is the need to adopt a unified pension regime. Such unification is desirable for both equity and efficiency reasons. A central theme of the paper is therefore to provide a framework for selecting a unified pension system. This framework allows a critical assessment of the new draft law for private pensions. In addition, an estimate of pension liabilities is provided to highlight the importance of moving towards a defined-contribution regime, but also to quantify the fiscal effect of some of the policy reforms that are being discussed in Peru, such as adopting a minimum pension guarantee.
Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes (2016)

Key features of this study include the revised diagnostic criteria with improved specificity and sensitivity, an unrestricted age range, and simultaneous assessment of multiple FTLD syndromes. The prevalence of FTD, PSP, and CBS increases beyond 65 years, with frequent genetic causes. The time from onset to diagnosis and from diagnosis to death varies widely among syndromes, emphasizing the challenge and importance of accurate and timely diagnosis. A high index of suspicion for FTLD syndromes is required by clinicians, even for older patients.