gebhart/patrepeval huggingface dataset:
Inhibition of allogeneic inflammatory responses by the Ribonucleotide Reductase Inhibitors, Didox and Trimidox (2010)

In conclusion, these data provide critical information to justify further investigation into the potential use of these compounds post allogeneic bone marrow transplantation to alleviate graft-versus-host disease thereby achieving better outcomes.
Effects of Drying and Agglomeration on the Dissolution of Multi‐Component Food Powders (2011)

Abstract This work proposes routes to produce dairy‐based multi‐component powders that meet nutritional and dissolution performance requirements. The effects of processing and composition on the physical properties of dairy powders were investigated and the relationship between such powder properties and dissolution performance was established. A spray‐dried milk‐based formulation was used as base powder, into which a carbohydrate, either starch or maltodextrin, was incorporated in varying proportions by dry mixing or fluid‐bed agglomeration. Physical properties such as particle size, density and flowability of the resulting powders were analyzed and particular attention was given to their dissolution behavior. Incorporation of either maltodextrin or starch in the final powder composition, without compromising the dissolution performance, was achieved by fluid‐bed agglomeration, provided that the amount of maltodextrin was less than 25 % or the amount of starch did not exceed 15 % and that the final agglomerate size was in the range of 250–300 μm.
Residual Stress in Alumina–Mullite Composites (1991)

Lattice strains have been measured by neutron diffraction from the alumina matrix in alumina–mullite composite cylinders. Infiltration processing results in a macroscopic variation of mullite concentration and residual stress throughout the samples. At the midheight of the cylinder, the stress component parallel to the cylinder axis is in a compression of −130 ± 30 MPa with respect to the value near the top surface. At the surfaces, the stress component parallel to the surface is in a compression of −130 ± 30 MPa with respect to values near the midheight of the cylinder. An overall tensile shift of the macroscopic stress profile in a fully infiltrated specimen is interpreted as a grain interaction effect between the alumina and mullite constituents. The positional dependence of the mullite phase concentration is also determined by neutron diffraction.
Codes defined on graphs (2003)

Low-density parity-check codes, turbo codes, and indeed most practically decodable capacity-approaching error correcting codes can all be understood as codes defined on graphs. Graphs not only describe the codes, but, more important, they structure the operation of the sum-product decoding algorithm (or one of many possible variations), which can be used for iterative decoding. Such coding schemes have the potential to approach channel capacity, while maintaining reasonable decoding complexity. In this tutorial article we review factor graphs, which can be used to describe codes and the joint probability distributions that must be dealt with in decoding. We also review the sum-product algorithm, and show how this algorithm leads to iterative decoding algorithms for codes defined on graphs.
An intrinsically photosensitive polyimide (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleAn intrinsically photosensitive polyimideJ. A. Moore and A. N. DasheffCite this: Chem. Mater. 1989, 1, 1, 163–166Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/cm00001a029https://doi.org/10.1021/cm00001a029research-articleACS PublicationsRequest reuse permissionsArticle Views656Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nanoscale Chemical Patterns Fabricated by Using Colloidal Lithography and Self-Assembled Monolayers (2004)

A method for preparing surfaces with well-defined nanoscale chemical patterns is described. The fabrication strategy involves creating nanoscale Au pits surrounded by a TiO2 matrix, or vice versa, using colloidal lithography, followed by selective functionalization of the Au areas by CH3-terminated alkanethiols. Using AFM force spectroscopy with chemically modified tips (OH, CH3), we show that the nanopatterned surfaces display strong chemical contrast, in the form of hydrophobic CH3 nanopatches surrounded by a hydrophilic TiO2 surface, or vice versa. The nanofabrication approach presented here offers several advantages over existing patterning technologies, among which are easiness (no sophisticated instrumentation is required), versatility (patterns with a range of surface functionalities can be prepared), and the possibility to produce patterns over large areas at low cost.
Preparation and Characterization of Impregnated Activated Carbon from Palm Kernel Shell and Coconut Shell for CO2 Capture (2016)

Activated carbon was produced from palm kernel shell (PKS) and coconut shell (CS) through physical steam activation and chemical activation. The optimum activation temperature for physical activation is 800oC and for chemical activation is 550oC. The activated carbons produced also loaded with different metal oxides (BaO, MgO, CuO, TiO2 and CeO2). Both loaded and unloaded activated carbons are characterized using ultimate analysis, BET surface area measurement method, fourier transform infrared (FT-IR) analysis and x-ray diffraction (XRD) analysis. The BET surface area and pore volumes showed that the activated carbons prepared from PKS by chemical activation (PCAC) and from CS by physical activation (CPAC) were found to be much higher than others activated carbons. Hence, the metal oxides were loaded on these two activated carbons. The loaded and unloaded activated carbons produced will be tested for application of CO2 adsorption from the simulated flue gas.
Lipid raft proteome reveals ATP synthase complex in the cell surface (2004)

Since detergent-resistant lipid rafts are involved in pathogen invasion, cholesterol homeostasis, angiogenesis, neurodegenerative diseases and signal transduction, protein identification in the rafts could provide important information to study their function. Here, we analyzed detergent-resistant raft proteins isolated from rat liver by capillary liquid chromatography-tandem mass spectrometry. Out of 196 proteins identified, 32% belonged to the raft or plasma membrane, 24% to mitochondrial, 20% to microsomal, 7% to miscellaneous, and 17% are unknown proteins. For example, membrane-bound receptors, trimeric GTP-binding proteins, ATP-binding cassette transporters, and glycosylphosphatidylinositol-anchored proteins were identified in this analysis. Unexpectedly, there were many mitochondrial proteins, raising a new issue for the presence of mitochondrial rafts or the localization of mitochondrial proteins into plasma membrane rafts. We confirmed that ATP synthase alpha and beta were expressed on the surface of the plasma membrane in HepG2 hepatocytes by immunofluorescence, cell surface biotinylation, and cellular fractionation. They had two distinct biochemical properties, detergent insolubility and low density, suggesting that the ATP synthase complex might be located in plasma membrane rafts as well as in the mitochondria.
A Distributed Comparison Algorithm for Train Inauguration Protocols over Ethernet (2010)

In this paper, we carry out a detailed investigation on two Train Inauguration Protocols proposed by WG43 for IEC 61375-2-5: ETB Train Inauguration (ETBTI) and Train Topology Discovery Protocol(T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> DP). ETBTI uses Layer 2 LLDP to discovery neighbor peers and uses Layer 3 ETBIP to broadcast the information of single node to all the others. On the other hand, T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> DP focuses on Layer 2 and modifies LLDP protocol slightly to achieve topology discovery in a simple way. In our opinion, T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> DP is more simple and more efficient than ETBTI. At the same time, we propose a Distributed Comparison Algorithm(DCA) that can be adopted by both ETBTI and T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> DP, in order to establish a stable Connectivity Table. Through rigorous theoretical analysis, we proof that the DCA algorithm is convergent, and the broadcasting complexity and computation complexity of DCA algorithm are 2/n of the method used by both ETBTI and T <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> DP. A significant performance improvement can be expected with a large number of n.
Botanical visualization of huge hierarchies (2005)

A new method for the visualization of huge hierarchical data structures is presented. The method is based on the observation that we can easily see the branches, leaves and their arrangement in a botanical tree, despite of the large number of elements. The strand model of Holton is used to convert an abstract tree into a geometric model. Non-leaf nodes are mapped to branches and child nodes to sub-branches. A naive application of this model leads to unsatisfactory results, hence it is tailored to suit our purposes better. Continuing branches are emphasized, long branches are contracted, and sets of leaves are shown as fruit. The method is applied to the visualization of directory structures. The elements, directories and files, as well as their relations can easily be extracted, thereby showing that the use of methods from botanical modeling can be effective for information visualization.
Identification of Mushroom Cultivars Using Image Analysis (1992)

The application of image analysis for variety testing of mushrooms [Agaricus bisporus (Lange) Imbach] to grant plant breeders rights was investigated. Images of 230 mushrooms were recorded under controlled lighting conditions. Image analysis techniques were used to increase the number of morphological characters that can be measured. The measurements of length, width, and a range of more or less complex shape descriptors, determined by means of image analysis, were statistically analyzed. Image analysis exhibited a significant improvement over previous methods which used only manual assessments.
Execution of robot‐assisted biopsies within the clinical context (1995)

This paper describes the first prostatic biopsy on a human patient using a robotic and telerobotic system. This system was designed at the Politecnico di Milano, and the biopsy was performed on April 7, 1995, in the Hospital Policlinico in Milan, Italy.
Black Women's Voices in the Women's Movement for Equal Rights: Pauli Murray and Patricia Williams (2008)

Black Women's Voices in the Women's Movement for Equal Rights:  Pauli Murray and Patricia Williams
Induction of Potent Humoral and Cell-Mediated Immune Responses Following Direct Injection of DNA Encoding the HIV Type 1 <i>env</i> and <i>rev</i> Gene Products (1995)

DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasmids encoding the HIV-1 envelope protein and the Rev regulatory protein. Injection of both plasmids into mice, rabbits, or macaques was found to induce high levels of specific antibodies capable of efficiently inhibiting both HIV-1 infection and envelope-mediated cell fusion. A readily detectable delayed-type hypersensitivity (DTH) response was demonstrable in injected mice and lymphocytes derived from these proliferated in response to an HIV-1 envelope V3 loop-specific peptide. Interestingly, the injected mice or macaques also developed a strong cytotoxic T lymphocyte (CTL) response against target cells pulsed with the V3 peptide. Taken together, these data demonstrate that injection of HIV-1 gene expression plasmids can induce potent humoral and cell-mediated immune responses and suggest that DNA vaccines may prove to be significantly beneficial as a means of immunizing against HIV-1.
Highly Selective Dopamine D<sub>3</sub> Receptor Antagonists with Arylated Diazaspiro Alkane Cores (2017)

A series of potent and selective D<sub>3</sub> receptor (D<sub>3</sub>R) analogues with diazaspiro alkane cores were synthesized. Radioligand binding of compounds 11, 14, 15a, and 15c revealed favorable D<sub>3</sub>R affinity (K<sub>i</sub> = 12-25.6 nM) and were highly selective for D<sub>3</sub>R vs D<sub>3</sub>R (ranging from 264- to 905-fold). Variation of these novel ligand architectures can be achieved using our previously reported 10-20 min benchtop C-N cross-coupling methodology, affording a broad range of arylated diazaspiro precursors.
Non-contact differential-mode on-wafer device characterization in the mmW and THz bands (2016)

We present a novel on-wafer metrology technique for characterization of differential Millimeter-wave and Terahertz Monolithic Integrated Circuits (MMIC and TMICs) using a contact-free setting that relies on quasi-optical coupling of test signals onto the device on chip. Due to their advantages over single-ended topologies, differential circuits are typically preferred, particularly for superior noise performance. However, lack of characterization equipment at sub-mmW frequencies severely inhibits the proliferation of differential MMIC and TMICs. Currently, balun-integrated wafer contacting probes are most commonly used for mixed mode S-parameter measurements. Nevertheless, these probes are commercially available only up to 110 GHz with prototypes proposed up to 140 GHz. In this paper, initial validation of novel, non-contact, differential-mode on-wafer probes is presented with validations for the 220-325 GHz.
Bag some aspirin. (2004)

Aspirin is an effective, vital, and extremely inexpensive component of treating acute coronary syndromes. However, during a routine review in 2003 of medical bags used by our staff, no aspirin was found.
Expedient Road Construction Over Sands Using Lightweight Mats (1998)

Technical Report
Ellipsometric study of polycrystalline silicon films prepared by low-pressure chemical vapor deposition (2000)

Polysilicon layers with thicknesses between 8 and 600 nm deposited by low-pressure chemical vapor deposition at temperatures ranging from 560 to 640 °C were characterized by spectroscopic ellipsometry (SE) to determine the layer thicknesses and compositions using multilayer optical models and the Bruggeman effective-medium approximation. The dependence of the structural parameters on the layer thickness and deposition temperature have been investigated. A better characterization of the polysilicon layer is achieved by using the reference data of fine-grained polysilicon in the optical model. The amount of voids in the polysilicon layer was independently measured by Rutherford backscattering spectrometry (RBS). The SE and RBS results show a good correlation. The comparison of the surface roughness measured by SE and atomic force microscopy (AFM) shows that independently of the AFM window sizes, a good correlation of the roughness determined by SE and AFM was obtained.
The application of polymerized lipid vesicles as colorimetric biosensors for real-time detection of pathogens in drinking water (2012)

The inadequate treatments given to the served waste water which are disposal to the rivers and sea coast are the major sources of faecal Microorganisms and enteric bacterial pathogens. They are among the most serious effects of water pollution bringing risks on public health. None of the current methods for detection of pathogens offer real-time on site solutions, are capable of delivering a simple visual detection signal, or can be easily instrumented as an indicator of the presence of a pathogen in water. The use of lipid vesicles incorporating Polydiacetylenes (PDAs) for the development of biosensors for "real-time" detection of pathogens has become an alternative, due to its potential for simple colorimetric response against harmful environmental effectors. However, its actual application in the field has been complicated because lipid vesicles are unable to respond specifically to environmental changes. In this paper, we report several experimental trials leading to improved response in the detection of flagellated pathogens in drinking water. Chromatic biomimetic membranes of TRCDA/DMPC and TRCDA/DMPC/Tryptophan were used in agar and liquid media, which were challenged with different amounts of Escherichia coli and Salmonella typhimurium . In addition, the effect of some divalent cations on the interaction with vesicles TRCDA/DMPC was investigated. The results indicated an improvement in the response times, both visually and quantitatively, through the use of TRIS-EDTA and proper growing conditions for E. coli and Salmonella . With the application of both conditions, it was possible by incubation at 35ºC to promote bacterial growth, therefore avoiding a dramatic effect on the colour change over control samples which may invalidate the test. Our experiments indicated that the minimum bacterial concentration necessary to produce the transition from blue to red on the vesicles as biosensor approaches 10 8 CFU/ml within 4 hrs, faster than traditional methods such as MPN or plate count agar. We present here incubations of samples of contaminated water at 35ºC, in agar plates containing chromatic biomimetic membranes of TRCDA/DMPC. A measurable colour transition is obtained within a reaction time of four hrs, which compares favourably with detection times between seven to 24 hrs corresponding to available tests.
A delta-driven execution model for semantic computing (2005)

We describe (and demonstrate) the execution model of a computing platform where computation is both incremental and data-driven. We call such an approach delta-driven. The platform is intended as a delivery vehicle for semantically integrated software, and thus lends itself to the semantic web, domain-driven development, and next-generation software development environments. Execution is transparent, versioned, and persistent. This technology - still at an early stage - is called domain/object.
Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis (1999)

This study has shown that hTFF2 enhances the rate of colonic epithelial repair, and reduces local inflammation in a rat model of colitis, and suggests that luminal application of trefoil peptides may have therapeutic potential in the treatment of inflammatory bowel disease.
Conceptual design of an angular multiplexed 50 kJ KrF amplifier for ICF (1981)

A conceptual design of an angular multiplexed 50 kJ KrF laser module is presented for use as a reactor driver for inertial confinement fusion (ICF). Such multiplexing is one approach to achieve the pulse compression needed for an efficient reactor driver. Optical designs are developed with emphasis placed on reducing prepulse problems and achieving acceptable optical quality. An axisymmetric optical design is identified as optimum in terms of simplicity, optical quality, cost, and ease of alignment. A kinetic code model for the KrF amplifier was used to derive scaling maps for the 50 kJ module with acceptable extraction efficiency and accounting for amplified spontaneous emission effects. The size of the module is constrained by parasitic suppression and damage threshold; the power gain is constrained by demanding 40 percent extraction efficiency in a double-pass extraction geometry, and the run time is constrained by the pulsed power technology and acceptable values of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g_{0}L</tex> . The bounds imposed on the design by the pulsed power technology were examined.
Predicting a Drug’s Membrane Permeability: A Computational Model Validated With <i>in Vitro</i> Permeability Assay Data (2017)

Membrane permeability is a key property to consider during the drug design process, and particularly vital when dealing with small molecules that have intracellular targets as their efficacy highly depends on their ability to cross the membrane. In this work, we describe the use of umbrella sampling molecular dynamics (MD) computational modeling to comprehensively assess the passive permeability profile of a range of compounds through a lipid bilayer. The model was initially calibrated through in vitro validation studies employing a parallel artificial membrane permeability assay (PAMPA). The model was subsequently evaluated for its quantitative prediction of permeability profiles for a series of custom synthesized and closely related compounds. The results exhibited substantially improved agreement with the PAMPA data, relative to alternative existing methods. Our work introduces a computational model that underwent progressive molding and fine-tuning as a result of its synergistic collaboration with numerous in vitro PAMPA permeability assays. The presented computational model introduces itself as a useful, predictive tool for permeability prediction.
Comparison of Solution and Crystal Structures of PreQ<sub>1</sub> Riboswitch Reveals Calcium-Induced Changes in Conformation and Dynamics (2011)

Riboswitches regulate gene expression via specific recognition of cognate metabolites by their aptamer domains, which fold into stable conformations upon ligand binding. However, the recently reported solution and crystal structures of the Bacillus subtilis preQ(1) riboswitch aptamer show small but significant differences, suggesting that there may be conformational heterogeneity in the ligand-bound state. We present a structural and dynamic characterization of this aptamer by solution NMR spectroscopy. The aptamer-preQ(1) complex is intrinsically flexible in solution, with two regions that undergo motions on different time scales. Three residues move in concert on the micro-to-millisecond time scale and may serve as the lid of the preQ(1)-binding pocket. Several Ca(2+) ions are present in the crystal structure, one of which binds with an affinity of 47 ± 2 μM in solution to a site that is formed only upon ligand binding. Addition of Ca(2+) to the aptamer-preQ(1) complex in solution results in conformational changes that account for the differences between the solution and crystal structures. Remarkably, the Ca(2+) ions present in the crystal structure, which were proposed to be important for folding and ligand recognition, are not required for either in solution.