gebhart/patrepeval huggingface dataset:
Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency (2005)

Recent advances in AAV-vector technology suggest that AAV-based vectors can be used for cancer gene therapy. Our comparative analysis revealed that, although AAV2 is the most promising candidate for such an application, serotypes 1 and 3 are valid alternatives. Furthermore, the use of self-complementary AAV vectors and proteasome inhibitors significantly improves cancer cell transduction.
[(+)-(R)-2,2'-Bis(diphenylphosphino)-6,6'-dimethylbiphenyl](8,9,10-trinorborna-2,5-diene)rhodium(I) tetrafluoroborate (1986)

Cristallisation dans le systeme orthorhombique, groupe P2 1 2 1 2 1 et affinement jusqu'a R=0,036. Coordination plan carre autour des atomes Rh
Assisted reproduction techniques in the horse (2012)

This paper reviews current equine assisted reproduction techniques. Embryo transfer is the most common equine ART, but is still limited by the inability to superovulate mares effectively. Immature oocytes may be recovered by transvaginal ultrasound-guided aspiration of immature follicles, or from ovaries postmortem, and can be effectively matured in vitro. Notably, the in vivo-matured oocyte may be easily recovered from the stimulated preovulatory follicle. Standard IVF is still not repeatable in the horse; however, embryos and foals can be produced by surgical transfer of mature oocytes to the oviducts of inseminated recipient mares or via intracytoplasmic sperm injection (ICSI). Currently, ICSI and in vitro embryo culture are routinely performed by only a few laboratories, but reported blastocyst development rates approach those found after bovine IVF (i.e. 25%-35%). Nuclear transfer can be relatively efficient (up to 26% live foal rate per transferred embryo), but few laboratories are working in this area. Equine blastocysts may be biopsied via micromanipulation, with normal pregnancy rates after biopsy, and accurate genetic analysis. Equine expanded blastocysts may be vitrified after collapsing them via micromanipulation, with normal pregnancy rates after warming and transfer. Many of these recently developed techniques are now in clinical use.
A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family (1997)

We have previously identified a 160-kDa protein in human embryonic kidney (HEK) 293 cells that undergoes rapid tyrosine phosphorylation in response to insulin (PY160) (Kuhné, M. R., Zhao, Z., and Lienhard, G. E. (1995) Biochem. Biophys. Res. Commun. 211, 190-197). The phosphotyrosine form of PY160 was purified from insulin-treated HEK 293 cells by anti-phosphotyrosine immunoaffinity chromatography, the sequences of peptides determined, and its cDNA cloned. The PY160 cDNA encodes a 1257-amino acid protein that contains, in order from its N terminus, a pleckstrin homology (PH) domain, a phosphotyrosine binding (PTB) domain, and, spread over the C-terminal portion, 12 potential tyrosine phosphorylation sites. Several of these sites are in motifs expected to bind specific SH2 domain-containing proteins: YXXM (7 sites), phosphatidylinositol 3-kinase; YVNM (1 site), Grb-2; and YIEV (1 site), either the protein-tyrosine phosphatase SHP-2 or phospholipase Cgamma. Furthermore, the PH and PTB domains are highly homologous (at least 40% identical) to those found in insulin receptor substrates 1, 2, and 3 (IRS-1, IRS-2, and IRS-3). Thus, PY160 is a new member of the IRS family, which we have designated IRS-4.
DCT Implementation on GPU (2022)

There has been a great progress in the field of graphics processors. Since, there is no rise in the speed of the normal CPU processors; Designers are coming up with multi-core, parallel processors. Because of their popularity in parallel processing, GPUs are becoming more and more attractive for many applications. With the increasing demand in utilizing GPUs, there is a great need to develop operating systems that handle the GPU to full capacity. GPUs offer a very efficient environment for many image processing applications. This thesis explores the processing power of GPUs for digital image compression using Discrete cosine transform.
An Experiment for Material Classification using Multichannel Radiographs. (2015)

Abstract not provided.
A complication of interference screw fixation in anterior cruciate ligament reconstruction. (1990)

Bone-tendon autografts using patellar tendon are rapidly becoming the autogenous grafts of choice for anterior cruciate ligament reconstruction. Patellar tendon is the strongest type of available autogenous tissue, and it is easily adaptable to arthroscopically assisted techniques. Secure immediate fixation is critical for the success of this procedure. The Kurosaka screw has emerged as one of the most reliable graft fixation methods. Although we have enjoyed much success with the Kurosaka screw, the following case represents the first report of failure with this fixation technique.
Introduction to stochastic computing and its challenges (2015)

We give a short overview of stochastic computing (SC) and its uses. SC computes with randomized bit-streams that loosely resemble the neural spike trains of the brain. Its key feature is the use of low-cost and low-power logic elements to implement complex numerical operations in a highly error-tolerant fashion. These advantages must be weighed against SC's inherently slow computing speed and low precision. Although studied sporadically since its invention in the 1960s, SC has regained interest recently as potentially suited to some emerging nanotechnologies, and to applications such as ECC decoding and biomedical image processing. However, a number of major challenges must be overcome if this potential is to be fully realized.
The role of bulk and interfacial morphology in charge generation, recombination, and extraction in non-fullerene acceptor organic solar cells (2020)

This study provides insight into the detailed bulk and interfacial morphological features critical in achieving high PCEs in polymer:NFA OSCs.
Visual Parrhesia?: Foucault and the Truth of the Gaze (2008)

Abstract How is it possible to conceive the future of the visual beyond the global “world picture” and its dominating gaze? This chapter answers this question by examining the genealogy of scopic that begins with the shift from the premodern ascetic regimes of truth to the practices of modern science, based on visual evidence. It focuses on the relationship between truth and the visual in the work of Michel Foucault, who is usually taken to exemplify French criticisms of the “ocularcentric” bias of Western thought. Consequently, the chapter considers the possibility of alternative visual practices that would oppose the power of the eye to dominate what it viewed and thereby dislodge the notion of truth as evidence or representation, embodying instead the risk of “truth-telling”.
Glucose repression in <i>Saccharomyces cerevisiae</i> is directly associated with hexose phosphorylation by hexokinases PI and PII (1991)

Genetic and biochemical analyses showed that hexokinase PII is mainly responsible for glucose repression in Saccharomyces cerevisiae, indicating a regulatory domain mediating glucose repression. Hexokinase PI/PII hybrids were constructed to identify the supposed regulatory domain and the repression behavior was observed in the respective transformants. The hybrid constructs allowed the identification of a domain (amino acid residues 102-246) associated with the fructose/glucose phosphorylation ratio. This ratio is characteristic of each isoenzyme, therefore this domain probably corresponds to the catalytic domain of hexokinases PI and PII. Glucose repression was associated with the C-terminal part of hexokinase PII, but only these constructs had high catalytic activity whereas opposite constructs were less active. Reduction of hexokinase PII activity by promoter deletion was inversely followed by a decrease in the glucose repression of invertase and maltase. These results did not support the hypothesis that a specific regulatory domain of hexokinase PII exists which is independent of the hexokinase PII catalytic domain. Gene disruptions of hexokinases further decreased repression when hexokinase PI was removed in addition to hexokinase PII. This proved that hexokinase PI also has some function in glucose repression. Stable hexokinase PI overproducers were nearly as effective for glucose repression as hexokinase PII. This showed that hexokinase PI is also capable of mediating glucose repression. All these results demonstrated that catalytically active hexokinases are indispensable for glucose repression. To rule out any further glycolytic reactions necessary for glucose repression, phosphoglucoisomerase activity was gradually reduced. Cells with residual phosphoglucoisomerase activities of less than 10% showed reduced growth on glucose. Even 1% residual activity was sufficient for normal glucose repression, which proved that additional glycolytic reactions are not necessary for glucose repression. To verify the role of hexokinases in glucose repression, the third glucose-phosphorylating enzyme, glucokinase, was stably overexpressed in a hexokinase PI/PII double-null mutant. No strong effect on glucose repression was observed, even in strains with 2.6 U/mg glucose-phosphorylating activity, which is threefold increased compared to wild-type cells. This result indicated that glucose repression is only associated with the activity of hexokinases PI and PII and not with that of glucokinase.
Are sprayed LbL-films stratified? A first assessment of the nanostructure of spray-assembled multilayers by neutron reflectometry (2008)

We describe first neutron reflectometry experiments on spray-assembled polyelectrolyte multilayer films containing regularly spaced layers of perdeuterated poly(styrene sulfonate). From samples containing either only non-deuterated layers or containing a maximum of deuterated layers we obtain all model parameters (thicknesses, scattering length densities and roughnesses) required for calculating the reflectivities of multilayer films with a regular superlattice structure. For two different superlattice films we show that we obtain an excellent match between experimental data and calculated reflectivities without any free fit parameter. Our data clearly demonstrate that spray-assembled polyelectrolyte multilayers are indeed stratified although some structural parameters differ enormously from films prepared by classic dipping. Our present experiments confirm a substantial difference in thickness and suggest a reduced interfacial roughness in spray-assembled films.
B-lineage regulated polyadenylation occurs on weak poly(A) sites regardless of sequence composition at the cleavage and downstream regions (1996)

Early/memory and plasma B-cell lines and fibroblasts were analyzed for their ability to use a 5' proximal (variant) versus a 3' distal (constant) poly(A) site, in the absence of a competing splice, from a set of related constructs. The proximal:distal poly(A) site use (P:D ratio) of the resulting cytoplasmic poly(A)+ mRNA is a measure of poly(A) site strength. In this context the immunoglobulin gamma2b secretory-specific poly(A) site showed a P:D ratio of 1:1 in plasma cells, 0.43:1 in early/memory B-cells and an intermediate value in fibroblasts. Meanwhile, a construct with a proximal SV40 early-like poly(A) site produced mRNA with a P:D ratio of >>50:1 in all cell types. Alterations in the region downstream of the proximal poly(A) addition site and at the site itself resulted in changes in the P:D ratio. However, these poly(A) sites, all with a P:D ratio of < or = 5:1, were used most efficiently in plasma cells. Constructs totally devoid of immunoglobulin sequences, but containing heterologous poly(A) sites producing mRNA with P:D ratios of < or = 5:1, were also used more efficiently in plasma cells. We therefore conclude that weak poly(A) sites, regardless of sequence composition, are used more efficiently in plasma cells than in the other cell types.
The projection neural network (2003)

A novel neural network model, the projection neural network, is developed to overcome three key drawbacks of backpropagation-trained neural networks (BPNN), i.e., long training times, the large number of nodes required to form closed regions for classification of high-dimensional problems and the lack of modularity. This network combines advantages of hypersphere classifiers, such as the restricted Coulomb energy (RCE) network, radial basis function methods, and BPNN. It provides the ability to initialize nodes to serve either as hyperplane separators or as spherical prototypes (radial basis functions), followed by a modified gradient descent error minimization training of the network weights and thresholds, which adjusts the prototype positions and sizes and may convert closed prototype decision boundaries to open boundaries, and vice versa. The network can provide orders of magnitude decrease in the required training time over BPNN and a reduction in the number of required nodes. Theory and examples are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Robust scene-change detection in MPEG compressed domain (1998)

Video is an important and challenging medium and requires sophisticated indexing schemes for efficient retrieval from visual databases. Video segmentation is a fundamental step in video indexing and involves detection of scene changes. In this paper, we propose a fast and robust algorithm for detecting video shot boundaries in the MPEG-2 compressed bit stream with minimal decoding.
Bushed, Bothered and Bamboozled (2001)

(2001). Bushed, Bothered and Bamboozled. The Black Scholar: Vol. 31, Black Election: 2000, pp. 14-17.
On Estimation of Fundamental Matrix in Computational Stereo. (1998)

We address the problem of estimating a fundamental matrix from a given set of corresponding pixels in two perspective images of a 3D scene that form a stereopair. The 3x3 fundamental matrix of rank 2 determines the corresponding epipolar lines in both images. Experiments with real stereo pairs have established the main reasons for instabilities of the well-known linear estimation based on the 8-parameter representation of a matrix. We compare three alternative 8-parameter representations and propose an enhanced estimation scheme that combines the linear estimation of the six parameters with the subsequent non-linear minimisation of the total distance between the corresponding pixels and relevant epipolar lines. The latter non-linear minimisation is done first by the direct exhaustion of the remaining two parameters and then by the local minimisation of the total distance in a vicinity of the minimum found by the exhaustion.
Automatic server to circuit mapping with the red pills (2010)

As fine grained power monitoring becomes crucial in data centers, a challenge raises on how to correctly map server identities to power circuits. Power provisioning, power capping, and power tracking all depend on ac-curately accounting which server consumes power from which circuit. Manual survey is cumbersome and er-ror prone. We describe a solution, called Red Pill, that can systematically and automatically identify the map-ping. The idea is to generate a power consumption pat-tern (a.k.a. a signature) by controlling CPU utilization, and to reliably detect it from circuit-level power mea-surements. We describe our implementation of the Red Pill system and evaluate it with real data traces. 1
The learning of novel finger movement sequences (1994)

1. Experienced typists typed phrases containing words in which one isolated letter was typed with one hand, while the remaining letters were typed with the contralateral hand. 2. The translational and rotational motion of the fingers and wrist of the right hand were obtained optoelectronically from the location of reflective markers placed on the fingers. 3. Midway through the experiment, the key corresponding to the isolated letter was physically switched with another key on the keyboard, and subjects typed the letter in its new location (for 140 trials). The letter "n," typed with the right index finger, was either switched with letters normally typed with the same finger (u), with a different finger but same hand (o), with the same finger of the left hand (v), or with a different finger of the left hand (w). 4. When the words were typed normally, the interkey intervals were relatively short, and the onset of movement of the right hand began before the preceding keypress with the left hand. Thus the movement of the two hands overlapped. Furthermore, the movement to the isolated key was highly stereotypical, with little trial-to-trial variability. 5. After the transposition of keys, there were prolongations in the interkey intervals, with the largest delay occurring directly before the typing of the transposed key. Switches between homologous fingers (involving mirror movements) delayed the onset of keypresses to a lesser extent than did other switches. With practice, these delays were reduced but never reached the control level. 6. After the keyswitch, the onset of movement to the isolated key did not occur on average until after the last keypress with the contralateral hand, except when the switch involved the use of homologous fingers. In the latter case, overlapping movement of the two hands was maintained. Thus the learning of a series of discrete movements does not necessarily require that each movement segment be performed sequentially. 7. After the transposition of keys, the movement pattern and time course to a given key were similar to the movement patterns for that key observed during control trials in all conditions. Thus the learning of a series of movements may involve the use of previously learned movements under new conditions. 8. The results suggest that typing movements may be organized at several levels, including the individual keystroke and word level.
Surface Modification and Functionalization of Nanoscale Metal-Organic Frameworks for Controlled Release and Luminescence Sensing (2020)

We describe in this paper a general method for synthesizing a new class of nanocomposites with a nanoscale metal-organic framework (NMOF) core and a silica shell. Silica shells of variable thickness were deposited on the NMOFs that had been surface-modified with polyvinylpyrrolidone (PVP) using a sol-gel procedure. The NMOF core of the nanocomposite could be completely removed (via dissolution) at low pH to afford hollow silica shells with varied thickness and aspect ratios. We also showed that the silica shell of such nanocomposites significantly stabilized the NMOF core against dissolution, thus demonstrating the ability to control the release of metal constituents from such silica-coated NMOFs. The silica shell was further functionalized with a silylated Tb-EDTA monoamide derivative for the luminescence sensing of dipicolinic acid (DPA), which is a major constituent of many pathogenic spore-forming bacteria. Owing to the tunability of NMOF composition and morphology, the present approach should allow for the synthesis of not only interesting nanoshells that are not accessible with presently available templates but also novel core-shell hybrid nanostructures for future imaging, sensing, and drug delivery applications.
Literacy and Technology (2013)

This chapter takes a look at technology and how it has influenced literacy through the ages. Technology has been utilized in writing since the Sumerians started using clay tablets and styluses and developed the cuneiform. This chapter also discusses prominent technology that has been used in the classroom from lead pencils and slates to iPads. With the invention of the Internet, a new form of literacy (Information Literacy) has also become important in education. Research has shown that the success or failure of the technology depends entirely on the teacher (Jonassen, 2003), and, in order for it to increase literacy and enhance instruction, students must be allowed to create their own learning using the tools that are natural to them.
Metallic source and drain module for FDSOI MOSFETs applications (2010)

We report on the development of metallic source and drain module for FDSOI MOSFETs including lateral salicidation of the channel edges and dopant segregation technique. Metal barrier type (TiN or Ti/TiN), optimized doping conditions, controlled PtSi penetration below spacers and suitable cleaning of the silicide surface lead to very low specific contact resistivity values (down to 0.1 Ωμm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). We thus demonstrate metallic source and drain pMOSFETs with promising electrical behavior suitable for high performance applications (Ion = 345 μA.μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> and Ioff = 30nA.μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> at -s1V for 50 nm gate length). Using a similar approach, we also demonstrate state-of-the-art nMOSFETs fabricated with not yet optimized Er and Yb salicidation processes.
Molecular Modelling of Aromatic Polyesters (1996)

Molecular simulation techniques have been used to study the chain and physical properties of isolated chains of aromatic polyesters for degree of polymerization (DP) 20 and 25. Molecular modelling of the aromatic polyesters: poly(ethylene terephthalate) (PET), poly(butylene terephthalate) (PBT), poly(ethylene isophthalate) (PEI) and poly(butylene isophthalate) (PBI) is reported. Advanced molecular mechanics and molecular dynamics simulation(s) make possible the prediction and design of new polymers not previously synthesised and characterised. Molecular dynamics can be used to analyse the time response of molecules. The geometry and energy of a molecule can be used to calculate many properties such as physical, chemical and mechanical; this is particularly true for polymers where the relationship of structure to many properties has been well established. A micro canonical molecular dynamics simulation of an isolated chain was performed for 500 picoseconds after equilibrium was established. The simulations were used to calculate radius of gyration, end-to-end distance, dipole moment, diffusion constant and total potential energy.