gebhart/patrepeval huggingface dataset:
Improvement of the Surface Roughness by Changing Chamfered Angle of the Insert in Face Milling (2001)

A milling process with 45 degree chamfered inserts produces a perfect flat surface only in theory. It is due to many unwanted factors including thermal effect, dynamic effect, the problem of the controller used and the problem of accuracy of the machine tool. In this study, introduced is a method to improve the surface roughness by redesigning of the chamfer angle of the insert, which traditionally has been 45 degree. First, the relationship between the fixed machine coordinate and the relative coordinate on the insert is derived. This transfer matrix is used to determine the new insert angle to maximize the flatness of the machined surface. A newly designed insert is manufactured, and used to carry out the experiment. It is proved that she insert designed by the proposed method produced a much flatter surface than a traditional one.
[Analysis of Time Distribution of Malaria Incidence in Baoshan City During 1990-2014]. (2015)

The malaria epidemic data in Baoshan city from 1990 to 2014 were analyzed with concentration ratio and circular distribution. Results showed that the incidence of malaria in Baoshan city displayed a trend of decrease from 1990 to 2014. The total concentration ration M was 0.36, the circular distribution r was 0.30, and the average angle α was 148.78°. The malaria incidence peaked on May 31, with the epidemic period being from March 2 to August 29, which is inconsistent with the seasonal ebb and flow of local malaria vector.
A Simple Model for Cyclic Variations in a Spark-Ignition Engine (1996)

<div class="htmlview paragraph">We propose a simple, physically oriented model that explains important characteristics of cyclic combustion variations in spark-ignited engines. A key model feature is the interaction between stochastic, small-scale fluctuations in engine parameters and nonlinear deterministic coupling between successive engine cycles. Prior-cycle effects are produced by residual cylinder gas which alters volume-average in-cylinder equivalence ratio and subsequent combustion efficiency. The model's simplicity allows rapid simulation of thousands of engine cycles, permitting in-depth statistical studies of cyclic variation patterns. Additional mechanisms for stochastic and prior-cycle effects can be added to evaluate their impact on overall engine performance. We find good agreement with our experimental data.</div>
Phase I/II clinical trial of 2‐difluoromethyl‐ornithine (DFMO) and a novel polyamine transport inhibitor (MQT 1426) for feline oral squamous cell carcinoma<sup>*</sup> (2011)

Polyamines are essential for cell proliferation. Their production is dysregulated in many cancers and polyamine depletion leads to tumour regression in mouse models of squamous cell carcinoma (SCC). The purpose of this study was to determine the maximally tolerated dose of the polyamine transport inhibitor, MQT 1426, when combined with the ornithine decarboxylase (ODC) inhibitor, DFMO, and to determine whether this therapy results in reduction in tumour polyamine levels. Thirteen cats with oral SCC received both drugs orally and serial tumour biopsies were obtained for polyamine measurement. Cats were monitored for response to therapy and toxicity. A maximum tolerated dose (MTD) of MQT 1426 when combined with DFMO was determined. Dose-limiting toxicity was vestibular in nature, but was fully reversible. Spermidine and total polyamine levels decreased significantly in tissues, two cats experienced objective tumour regression and six cats had stable disease. These results suggest that further study of polyamine depletion therapies is warranted.
A New Family of Ultralow Loss Reversible Phase‐Change Materials for Photonic Integrated Circuits: Sb<sub>2</sub>S<sub>3</sub> and Sb<sub>2</sub>Se<sub>3</sub> (2020)

Abstract Phase‐change materials (PCMs) are seeing tremendous interest for their use in reconfigurable photonic devices; however, the most common PCMs exhibit a large absorption loss in one or both states. Here, Sb 2 S 3 and Sb 2 Se 3 are demonstrated as a class of low loss, reversible alternatives to the standard commercially available chalcogenide PCMs. A contrast of refractive index of Δ n = 0.60 for Sb 2 S 3 and Δ n = 0.77 for Sb 2 Se 3 is reported, while maintaining very low losses ( k < 10 −5 ) in the telecommunications C‐band at 1550 nm. With a stronger absorption in the visible spectrum, Sb 2 Se 3 allows for reversible optical switching using conventional visible wavelength lasers. Here, a stable switching endurance of better than 4000 cycles is demonstrated. To deal with the essentially zero intrinsic absorption losses, a new figure of merit (FOM) is introduced taking into account the measured waveguide losses when integrating these materials onto a standard silicon photonics platform. The FOM of 29 rad phase shift per dB of loss for Sb 2 Se 3 outperforms Ge 2 Sb 2 Te 5 by two orders of magnitude and paves the way for on‐chip programmable phase control. These truly low‐loss switchable materials open up new directions in programmable integrated photonic circuits, switchable metasurfaces, and nanophotonic devices.
Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease (2017)

These results demonstrate the efficacy of antisense suppression for an astrocyte target, and provide a compelling therapeutic approach for Alexander disease. Ann Neurol 2018;83:27-39.
CAD-based pose estimation for random bin-picking of multiple objects using a RGB-D camera (2015)

In this paper, we propose a CAD-based 6-DOF pose estimation design for random bin-picking of multiple different objects using a Kinect RGB-D sensor. 3D CAD models of objects are constructed via a virtual camera, which generates a point cloud database for object recognition and pose estimation. A voxel grid filter is suggested to reduce the number of 3D point cloud of objects for reducing computing time of pose estimation. A voting-scheme method was adopted for the 6-DOF pose estimation a swell as object recognition of different type objects in the bin. Furthermore, an outlier filter is designed to filter out bad matching poses and occluded ones, so that the robot arm always picks up the upper object in the bin to increase pick up success rate. A series of experiments on a Kuka 6-axis robot revels that the proposed system works satisfactorily to pick up all random objects in the bin. The average recognition rate of three different type objects is 93.9% and the pickup success rate is 89.7%.
A Simple Real-Time Method For Calibrating A Camera Mounted On A Robot For Three Dimensional Machine Vision (1989)

For a vision system to infer 3D object features (e.g., point features or line features) from 2D image features and to predict 2D image features from 3D object features, the transformation between the 2D image coordinate system and the 3D object coordinate system must be known. Determining this transformation is called (geometric) camera calibration. This 2D-3D transformation varies when the camera is moved by a robot. This paper presents a simple two-stage (off-line stage and on-line stage) method for calibrating a camera mounted on a robot. The off-line stage includes off-line calibration of the camera, the robot, and the robot-camera (or hand-eye) relation. The on-line stage can be divided into an initial calculation step and a re-calibration step. The initial step is computationally simple since it only involves one or two matrix multiplications of dimension less than four. The derived calibration accuracy from this initial step depends on the accuracy of the off-line camera/robot calibration. Experimental results show that the calibration accuracy is better than "1 part in 1000" without special robot calibration. Higher accuracy can be obtained with more sophisticated robot calibration, or with the re-calibration step using the extended Kalman filtering techniques. Some new insights to the conventional camera calibration methods are also given.
Immunology of Intracellular Parasitism (1998)

Intracellular prokaryotic and eukaryotic organisms cause some of the most intractable problems in the fields of human and animal infectious diseases. Such infections are characteristically long and chronic and accompanied by deleterious immunopathological changes. The nine chapters in this volume, all written by internationally acknowledged experts
Methodology for Realizing VMM with Binary RRAM Arrays: Experimental Demonstration of Binarized-ADALINE using OxRAM Crossbar (2020)

In this paper, we present an efficient hardware mapping methodology for realizing vector matrix multiplication (VMM) on resistive memory (RRAM) arrays. Using the proposed VMM computation technique, we experimentally demonstrate a binarized-ADALINE (Adaptive Linear) classifier on an OxRAM crossbar. An 8×8 OxRAM crossbar with Ni/3-nm HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /7 nm Al-doped-TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /TiN device stack is used. Weight training for the binarized-ADALINE classifier is performed ex-situ on UCI cancer dataset. Post weight generation the OxRAM array is carefully programmed to binary weight-states using the proposed weight mapping technique on a custom-built testbench. Our VMM powered binarized-ADALINE network achieves a classification accuracy of 78% in simulation and 67% in experiments. Experimental accuracy was found to drop mainly due to crossbar inherent sneak-path issues and RRAM device programming variability.
Antigen-binding activity of antibodies immobilized on styrene copolymer beads. (1990)

An important element of the Kodak thin-film immunoassay is antibody immobilized on small polymer beads. Monodisperse styrene copolymer beads offer a well-defined, high surface area substrate for covalent immobilization of monoclonal antibodies. The authors have used the ability of an immobilized monoclonal antibody directed against phenobarbitol, Phe 1.9, to recognize an antigen-enzyme conjugate to determine the extent of antibody activity retention and find that the packing density of antibody at the surface and the copolymer composition are important variables. For polystyrene homopolymer and some copolymers, antibody retention is greater as the packing density at the surface increases. Small changes in the copolymer composition, such as addition of 1% acrylamide or 10% acrylic acid, significantly increase the retention of binding activity of the antibody. The chemistry for covalent coupling of the antibody to the surface is also important. Phe 1.9 coupled to chloromethyl styrene copolymer beads retains less activity than when coupled to vinyl sulfone copolymer beads. Monodisperse sytrene copolymer beads provide great flexibility in the design of rapid immunoassays since a copolymer bead can be tailored to the specific requirements of the antibody and the analyte.
New and TALENted Genome Engineering Toolbox (2013)

Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this review emphasizes the latest developments in genome engineering and how applications within the field are transforming our understanding of personalized medicine with an emphasis on cardiovascular diseases.
Rapid and Simple Purification of Lysozyme from the Egg Shell Membrane (2015)

Lysozyme (EC 3.2.1.17) is a hydrolytic enzyme that cleaves the β-(1,4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan, a major bacterial cell wall polymer. In the food industry, lysozyme is used as an additive mainly in the production of wine and beer. Lysozyme was found to be localized in the egg shell membrane. In this study, we found that lysozyme was easily purified from the egg shell membrane and that the enzyme also had antibacterial activity. Furthermore, we found that the antibacterial activity of purified lysozyme from the egg shell membrane was lower than that of purified lysozyme from the egg white at alkaline pH. The method for rapid purification of lysozyme developed in this study should contribute to the food industry.
Learning and synthesizing MPEG-4 compatible 3-D face animation from video sequence (2003)

We present a new system that applies an example-based learning method to learn facial motion patterns from a video sequence of individual facial behavior such as lip motion and facial expressions, and using that to create vivid three-dimensional (3-D) face animation according to the definition of MPEG-4 face animation parameters. The system consists of three key modules, face tracking, pattern learning, and face animation. In face tracking, to reduce the complexity of the tracking process, a novel coarse-to-fine strategy combined with a Kalman filter is proposed for localizing key facial landmarks in each image of the video. The landmarks' sequence is normalized into a visual feature matrix and then fed to the next step of process. In pattern learning, in the pretraining stage, the parameters of the camera that took the video are requested with the training video data so the system can estimate the basic mapping from a normalized two-dimensional (2-D) visual feature matrix to the representation in 3-D MPEG-4 face animation parameter space, in assistance with the computer vision method. In the practice stage, considering that in most cases camera parameters are not provided with video data, the system uses machine learning technology to complement the incomplete 3-D information for the mapping that information is needed in face orientation presentation. The example-based learning in this system integrates several methods including clustering, HMM, and ANN to make a better conversion from a 2-D to 3-D model and better estimation of incomplete 3-D information for good mapping; this will be used to drive face animation thereafter. In face animation, the system can synthesize face animation following any type of face motion in video. Experiments show that our system produces more vivid face motion animation, compared to other early systems.
Interactions of <i>Cryptosporidium parvum</i> , <i>Giardia lamblia</i> , Vaccinal Poliovirus Type 1, and Bacteriophages φX174 and MS2 with a Drinking Water Biofilm and a Wastewater Biofilm (2008)

ABSTRACT Biofilms colonizing surfaces inside drinking water distribution networks may provide a habitat and shelter to pathogenic viruses and parasites. If released from biofilms, these pathogens may disseminate in the water distribution system and cause waterborne diseases. Our study aimed to investigate the interactions of protozoan parasites ( Cryptosporidium parvum and Giardia lamblia [oo]cysts) and viruses (vaccinal poliovirus type 1, φX174, and MS2) with two contrasting biofilms. First, attachment, persistence, and detachment of the protozoan parasites and the viruses were assessed with a drinking water biofilm. This biofilm was allowed to develop inside a rotating annular reactor fed with tap water for 7 months prior to the inoculation. Our results show that viable parasites and infectious viruses attached to the drinking water biofilm within 1 h and persisted within the biofilm. Indeed, infectious viruses were detected in the drinking water biofilm up to 6 days after the inoculation, while viral genome and viable parasites were still detected at day 34, corresponding to the last day of the monitoring period. Since viral genome was detected much longer than infectious particles, our results raise the question of the significance of detecting viral genomes in biofilms. A transfer of viable parasites and viruses from the biofilm to the water phase was observed after the flow velocity was increased but also with a constant laminar flow rate. Similar results regarding parasite and virus attachment and detachment were obtained using a treated wastewater biofilm, suggesting that our observations might be extrapolated to a wide range of environmental biofilms and confirming that biofilms can be considered a potential secondary source of contamination.
Recombinant Decorin Glycoforms (1996)

The vaccinia virus/T7 bacteriophage expression system was used to express human decorin in HT-1080 cells by co-infection with vTF7-3, encoding T7 RNA polymerase, and vDCN1, encoding the decorin core protein fused to a polyhistidine-insulin signal sequence fusion-protein cassette. Overexpression using the vaccinia virus/T7 phage system resulted in secretion of approximately 30 mg of decorin/10(9) cells per 24 h which enabled purification and separation of multiple glycoforms under native conditions. Cells were cultured in the presence of [35S]methionine or a mixture of [3H]glucosamine and [35S]sulfate, and recombinant glycoprotein purified by metal affinity chromatography which resolved the secreted decorin into two classes, a proteoglycan form and a core protein form. About 25% of the recombinant protein was secreted into the culture medium as core protein devoid of glycosaminoglycan chains. The decorin core protein was resolved into two forms (approximately 49 and approximately 53 kDa) that differed in the extent of N-linked oligosaccharide substitution (2 and 3 N-linked oligosaccharides, respectively). Deglycosylation of the recombinant proteoglycans and core proteins resulted in a single band migrating with an apparent molecular mass approximately 43 kDa when analyzed by SDS-polyacrylamide gel electrophoresis. Far-UV circular dichroism spectra of native decorin proteoglycan showed a minima at 218 nm, consistent with a secondary structure that is predominantly beta-sheet. Circular dichroism spectra of bovine decorin extracted from articular cartilage and recombinant decorin similarly treated revealed a minima of 205 nm indicating a loss of secondary structure. The affinity of decorin proteoglycan and core protein for collagen-like molecules was demonstrated, with the complement component C1q exhibiting the most striking affinity for decorin, although adherence to collagen types I and V was also observed. The extensive secondary structure maintained in the purified recombinant protein is likely to be important for the biological function of decorin.
(14-002) Director-General, Department of Planning and Infrastructure v Aston Coal 2 Pty Ltd [2013] NSWLEC 188 (2014)

The defendant pleaded guilty to two offences against s 125 of the EPA Act in that it failed to report to the Director-General, as it was required to do by s 147(3) of the EPA Act, that two of its directors and then CEO and CFO had each made a 'reportable political donation' in respect of a 'planning application'. On 16 August 2010, the defendant lodged a Major Project Application under the former Pt 3A for the carrying out of the Maules Creek Coal Project. At the time the two directors had entered into a s 147 'long term incentive plan' with the defendant constituting an option to purchase shares in the defendant at a discounted price if coal was obtained from the Project before August 2013. This satisfied the definition of a relevant 'financial interest' under s 147(3). Subsequent to making the planning application, but still within the triggering timeframe of s 147, the two directors made donations to the NSW National Party of $5,000 and $4,250.
Automatic clustering-based segmentation and plaque localization in psoriasis digital images (2017)

Psoriasis is one of the most stressful skin diseases. The accurate assessment and effective management of the disease is one of the contributing factors in reducing the time required for relieving the disease symptoms. As the treatment is unusually subjective, an automatic and efficient computer aided assessment technique is an active area of research. In this study, we developed an automatic psoriasis segmentation and plaque localization system using images captured by a digital camera. Our work differs from other studies by improving the segmentation of lesion regions and using a novel region based color feature extractor for classification of psoriasis plaques from healthy skin areas. The proposed modified k-means clustering based segmentation approach resulted in an accuracy of 93.83% in comparison to the ground truth, which is around 10% more than reported results by others with the same database. Statistical analysis was performed to determine psoriasis biomarkers, and the effectiveness of these biomarkers was validated by developing a machine learning model consisting of support vector machine (SVM) classifier to identify the psoriasis plaques automatically. The classification model predicted the disease plaques with an acceptable accuracy of 86.83% and thus the automated psoriasis segmentation and plaque localization technique developed in this study provide the foundation towards designing an objective assessment system for psoriasis.
A hierarchy of detail for fast collision detection (2002)

The paper presents a general object representation for efficient collision detection. Spatial representation is a crucial factor when motion planning is applied to real environments with complex objects, since the efficiency of the collision detection algorithms depends on the spatial representation used for the agents and obstacles in the scene. Our spatial model consists of a hierarchy of representations that approximates the object at different levels of detail. The input to the system is any object that could be described using non-homogeneous generalized cylinders. An algorithm that automatically converts between polyhedral approximations and generalized cylinders extends the applicability of the approach. Compared with related approaches in the literature, our system can deal with concave and curved objects, it is spatially balanced, complete, stable and converges to a zero-error model. Experimental results show that better approximations are obtained (in terms of quality), and computation times are even two orders of magnitude less. The approach has been applied to solve collisions in a scene where human beings and robots interact. This is a fundamental requirement towards human-safe service robotics.
Optimizing 360 video delivery over cellular networks (2016)

As an important component of the virtual reality (VR) technology, 360-degree videos provide users with panoramic view and allow them to freely control their viewing direction during video playback. Usually, a player displays only the visible portion of a 360 video. Thus, fetching the entire raw video frame wastes bandwidth. In this paper, we consider the problem of optimizing 360 video delivery over cellular networks. We first conduct a measurement study on commercial 360 video platforms. We then propose a cellular-friendly streaming scheme that delivers only 360 videos' visible portion based on head movement prediction. Using viewing data collected from real users, we demonstrate the feasibility of our approach, which can reduce bandwidth consumption by up to 80% based on a trace-driven simulation.
Comparison of neurokinin A and substance P on cardiovascular and airway function in man. (1988)

The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion. SP caused bronchodilation and NKA bronchoconstriction. NKA and SP have differing physiological roles and may activate different receptor populations.