gebhart/patrepeval huggingface dataset:
Adrenal response to corticotropin during therapy with itraconazole (1987)

Itraconazole is a triazole with a mechanism of action similar to that of ketoconazole. Endocrine side effects of ketoconazole, including impaired cortisol synthesis, have been well documented (A. Pont, J. R. Graybill, P. C. Craven, J. N. Galgiani, W. E. Dismukes, R. E. Reitz, and D. A. Stevens, Arch. Intern. Med. 144:2150-2153, 1984). We examined the adrenal response to corticotropin in 10 patients being treated with itraconazole. No impairment of cortisol synthesis could be demonstrated.
Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance (2010)

Intrinsically disordered proteins (IDPs) lack well-defined structure but are widely represented in eukaryotic proteomes. Although the functions of most IDPs are not understood, some have been shown to have molecular recognition and/or regulatory roles where their disordered nature might be advantageous. Anhydrin is an uncharacterized IDP induced by dehydration in an anhydrobiotic nematode, Aphelenchus avenae. We show here that anhydrin is a moonlighting protein with two novel, independent functions relating to desiccation tolerance. First, it has a chaperone-like activity that can reduce desiccation-induced enzyme aggregation and inactivation in vitro. When expressed in a human cell line, anhydrin localizes to the nucleus and reduces the propensity of a polyalanine expansion protein associated with oculopharyngeal muscular dystrophy to form aggregates. This in vivo activity is distinguished by a loose association of anhydrin with its client protein, consistent with a role as a molecular shield. In addition, anhydrin exhibits a second function as an endonuclease whose substrates include supercoiled, linear, and chromatin linker DNA. This nuclease activity could be involved in either repair of desiccation-induced DNA damage incurred during anhydrobiosis or in apoptotic or necrotic processes, for example, but it is particularly unexpected for anhydrin because IDP functions defined to date anticorrelate with enzyme activity. Enzymes usually require precise three-dimensional positioning of residues at the active site, but our results suggest this need not be the case. Anhydrin therefore extends the range of IDP functional categories to include catalysis and highlights the potential for the discovery of new functions in disordered proteomes.
High quality GaAs qrowth by MBE on Si using GeSi buffers and prospects for space photovoltaics (2000)

III–V solar cells on Si substrates are of interest for space photovoltaics since this would combine high performance space cells with a strong, lightweight and inexpensive substrate. However, the primary obstacles blocking III–V/Si cells from achieving high performance to date have been fundamental material incompatibilities, namely the 4% lattice mismatch between GaAs and Si, and the large mismatch in thermal expansion coefficient. In this paper, we report on the molecular beam epitaxial (MBE) growth and properties of GaAs layers and single junction GaAs cells on Si wafers which utilize compositionally graded GeSi intermediate buffers grown by ultra-high vacuum chemical vapor deposition (UHVCVD) to mitigate the large lattice mismatch between GaAs and Si. GaAs cell structures were found to incorporate a threading dislocation density of 0.9–1.5×10 cm−2, identical to the underlying relaxed Ge cap of the graded buffer, via a combination of transmission electron microscopy, electron beam induced current, and etch pit density measurements. AlGaAs/GaAs double heterostructures were grown on the GeSi/Si substrates for time-resolved photoluminescence measurements, which revealed a bulk GaAs minority carrier lifetime in excess of 10 ns, the highest lifetime ever reported for GaAs on Si. A series of growths were performed to assess the impact of a GaAs buffer layer that is typically grown on the Ge surface prior to growth of active device layers. We found that both the high lifetimes and low interface recombination velocities are maintained even after reducing the GaAs buffer to a thickness of only 0.1 μm. Secondary ion mass spectroscopy studies revealed that there is negligible cross diffusion of Ga, As and Ge at the III–V/Ge interface, identical to our earlier findings for GaAs grown on Ge wafers using MBE. This indicates that there is no need for a buffer to ‘bury’ regions of high autodoping, and that either pn or np configuration cells are easily accommodated by these substrates. Preliminary diodes and single junction AlGaAs heteroface cells were grown and fabricated on the Ge/GeSi/Si substrates for the first time. Diodes fabricated on GaAs, Ge and Ge/GeSi/Si substrates show nearly identical I–V characteristics in both forward and reverse bias regions. External quantum efficiencies of AlGaAs/GaAs cell structures grown on Ge/GeSi/Si and Ge substrates demonstrated nearly identical photoresponse, which indicates that high lifetimes, diffusion lengths and efficient minority carrier collection is maintained after complete cell processing. Copyright © 2000 John Wiley & Sons, Ltd.
Ultrasound‐Triggered Regulation of Blood Glucose Levels Using Injectable Nano‐Network (2013)

The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vitro and in vivo. A single subcutaneous injection of the nano-network with intermittent FUS administration facilitates reduction of the blood glucose levels in type 1 diabetic mice for up to 10 d.
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits Have Divergent Roles in Virulence Factor Production in Two Varieties of the Fungal Pathogen <i>Cryptococcus neoformans</i> (2004)

Our earlier findings established that cyclic AMP-dependent protein kinase functions in a signaling cascade that regulates mating and virulence of Cryptococcus neoformans var. grubii (serotype A). Mutants lacking the serotype A protein kinase A (PKA) catalytic subunit Pka1 are unable to mate, fail to produce melanin or capsule, and are avirulent in animal models, whereas mutants lacking the PKA regulatory subunit Pkr1 overproduce capsule and are hypervirulent. Because other mutations have been observed to confer different phenotypes in two diverged varieties of C. neoformans (grubii variety [serotype A] and neoformans variety [serotype D]), we analyzed the functions of the PKA genes in the serotype D neoformans variety. Surprisingly, the Pka1 catalytic subunit was not required for mating, haploid fruiting, or melanin or capsule production of serotype D strains. Here we identify a second PKA catalytic subunit gene, PKA2, that is present in both serotype A and D strains of C. neoformans. The divergent Pka2 catalytic subunit was found to regulate mating, haploid fruiting, and virulence factor production in serotype D strains. In contrast, Pka2 has no role in mating, melanin production, or capsule formation in serotype A strains. Our studies illustrate how different components of signaling pathways can be co-opted and functionally specialized during the evolution of related but distinct varieties or subspecies of a human fungal pathogen.
A Grid service broker for scheduling e‐Science applications on global data Grids (2005)

Abstract The next generation of scientific experiments and studies, popularly called e‐Science, is carried out by large collaborations of researchers distributed around the world engaged in the analysis of huge collections of data generated by scientific instruments. Grid computing has emerged as an enabler for e‐Science as it permits the creation of virtual organizations that bring together communities with common objectives. Within a community, data collections are stored or replicated on distributed resources to enhance storage capability or the efficiency of access. In such an environment, scientists need to have the ability to carry out their studies by transparently accessing distributed data and computational resources. In this paper, we propose and develop a Grid broker that mediates access to distributed resources by: (a) discovering suitable data and computational resources sources for a given analysis scenario; (b) optimally mapping analysis jobs to resources; (c) deploying and monitoring job execution on selected resources; (d) accessing data from local or remote data sources during job execution; and (e) collating and presenting results. The broker supports a declarative and dynamic parametric programming model for creating Grid applications. We have used this model in Grid‐enabling a high‐energy physics analysis application (the Belle Analysis Software Framework). The broker has been used in deploying Belle experimental data analysis jobs on a Grid testbed, called the Belle Analysis Data Grid, having resources distributed across Australia interconnected through GrangeNet. Copyright © 2005 John Wiley & Sons, Ltd.
Cytotoxicity Associated with Trichloroethylene Oxidation in <i>Burkholderia cepacia</i> G4 (2001)

ABSTRACT The effects of trichloroethylene (TCE) oxidation on toluene 2-monooxygenase activity, general respiratory activity, and cell culturability were examined in the toluene-oxidizing bacterium Burkholderia cepacia G4. Nonspecific damage outpaced inactivation of toluene 2-monooxygenase in B. cepacia G4 cells. Cells that had degraded approximately 0.5 μmol of TCE (mg of cells −1 ) lost 95% of their acetate-dependent O 2 uptake activity (a measure of general respiratory activity), yet toluene-dependent O 2 uptake activity decreased only 35%. Cell culturability also decreased upon TCE oxidation; however, the extent of loss varied greatly (up to 3 orders of magnitude) with the method of assessment. Addition of catalase or sodium pyruvate to the surfaces of agar plates increased enumeration of TCE-injured cells by as much as 100-fold, indicating that the TCE-injured cells were ultrasensitive to oxidative stress. Cell suspensions that had oxidized TCE recovered the ability to grow in liquid minimal medium containing lactate or phenol, but recovery was delayed substantially when TCE degradation approached 0.5 μmol (mg of cells −1 ) or 66% of the cells' transformation capacity for TCE at the cell density utilized. Furthermore, among B. cepacia G4 cells isolated on Luria-Bertani agar plates from cultures that had degraded approximately 0.5 μmol of TCE (mg of cells −1 ), up to 90% were Tol − variants, no longer capable of TCE degradation. These results indicate that a toxicity threshold for TCE oxidation exists in B. cepacia G4 and that once a cell suspension has exceeded this toxicity threshold, the likelihood of reestablishing an active, TCE-degrading biomass from the cells will decrease significantly.
Mechanical Properties of Polypropylene Fibre-reinforced Soil (2016)

In order to solve the problem of excessive deformation of sandy soil at road foundation caused by mining and automobile with heavy duty,we study the strength and deformation resistance of sandy soil under four different fiber lengths and blending amounts through triaxial compression test. Results show that the stress-strain relation of fiber-reinforced soil is approximately a hyperbolic function,in which the main failure form is swollen failure. With the increase of blending proportion and length of fibre,the mechanical properties of fibre-reinforced soil strengthen,but the angle of internal friction is barely affected. Finally,a fitting formula of cohesion vs. fiber length and mixing amount is obtained by multivariate regression analysis based on the 1st Opt experiment and the results meet the requirement of actual projects by comparison with measured data.
Gene Therapy: Efforts at Developing Large Animal Models for Autologous Bone Marrow Transplant and Gene Transfer with Retroviral Vectors (2007)

Two new large animal models, non-human primates and fetal sheep, have been developed in an effort to determine the feasibility of using retroviruses for gene therapy. The retroviral vectors N2 and SAX have been used to introduce the genes for neomycin phosphotransferase (neoR, conferring resistance to the antibiotic G418) and human adenosine deaminase (ADA; EC 3.5.4.17), respectively. Varying levels of human ADA activity have been detected in six of the eight SAX-treated monkeys analysed. In the monkey with the greatest activity, human ADA levels approximately 0.5% of endogenous monkey ADA levels were detected. By in situ hybridization, roughly one in 100 bone marrow cells were found to express vector DNA. Sheep have been used for studies of the infectability of fetal blood progenitors in vivo. Blood cells were treated with the N2 vector at the 96th day of gestation, and marrow cells were assayed for the presence of G418-resistant haematopoietic progenitors, starting from one week after birth (62 days after treatment). Up to 33% of colony-forming progenitors were drug resistant initially and, although the proportion of resistant colony-forming units declined, a level of 10% has been found 153 days after transplantation. Human bone marrow has also been treated with the N2 vector, resulting in 1-2% G418-resistant progenitors.
Origin of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mn>1</mml:mn><mml:mn>1</mml:mn><mml:mn>5</mml:mn><mml:mn>0</mml:mn><mml:mo>−</mml:mo><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant="normal">cm</mml:mi></mml:mrow><mml:mrow><mml:mi>−</mml:mi><mml:mn>1</mml:mn></mml:mrow></mml:msup></mml:mrow></mml:math>Raman mode in nanocrystalline diamond (2001)

The peak near 1150 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ in the visible Raman spectra of poor quality chemical-vapor-deposited diamond is often used as the signature of nanocrystalline diamond. We argue that this peak should not be assigned to nanocrystalline diamond or other ${\mathrm{sp}}^{3}$-bonded phases. Its wave number disperses with excitation energy, its intensity decreases with increasing excitation energy, and it is always accompanied by another peak near 1450 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, which acts similarly. This behavior is that expected for ${\mathrm{sp}}^{2}$-bonded configurations, with their smaller band gap. The peaks are assigned to transpolyacetylene segments at grain boundaries and surfaces.
Silage microbiology and its control through additives (2010)

Ensiling is a method of preserving a moist crop. A moist crop can support the growth of a wide range of microorganisms, most of which will degrade the nutrient value to livestock. However, ensiling generally controls microbial activity by a combination of an anaerobic environment and a natural fermentation of sugars by lactic acid bacteria on the crop. This fermentation and the resulting low pH primarily suppress the growth of other anaerobic microorganisms. The fermentation can also inhibit yeasts, molds and aerobic bacteria, but the anaerobic environment is essential to preventing most of the spoilage microorganisms from growing. Inoculants have become the dominant additives for making silage. Homofermentative strains help guarantee a rapid suppression of anaerobic stains early in storage, increase dry matter recovery and have improved animal performance by means that we do not fully understand. Inoculants containing Lactobacillus buchneri, a heterofermentative species capable of fermenting lactic acid to acetic, are recent additives. The added acetic acid inhibits yeast and mold growth, increasing aerobic stability of silages at feeding.
Pioglitazone Treatment Increases Spontaneous Growth Hormone (GH) Secretion and Stimulated GH Levels in Polycystic Ovary Syndrome (2005)

Pioglitazone treatment significantly increased GHRH-stimulated GH levels and 24-h pulsatile GH secretion, probably directly or indirectly due to improved insulin sensitivity.
<title>Quantization of color image components in the DCT domain</title> (1991)

Several topics connecting basic vision research to image compression and image quality are discussed: (1) A battery of about 7 specially chosen simple stimuli should be used to tease apart the multiplicity of factors affecting image quality. (2) A 'perfect' static display must be capable of presenting about 135 bits/min2. This value is based on the need for 3 pixels/min and 15 bits/pixel. (3) Image compression allows the reduction from 135 to about 20 bits/min2 for perfect image quality. 20 bit/min2 is the information capacity of human vision. (4) A presumed weakness of the JPEG standard is that it does not allow for Weber's Law nonuniform quantization. We argue that this is an advantage rather than a weakness. (5) It is suggested that all compression studies should report two numbers separately: the amount of compression achieved from quantization and the amount from redundancy coding. (6) The DCT, wavelet and viewprint representations are compared. (7) Problems with extending perceptual losslessness to moving stimuli are discussed. Our approach of working with a 'perfect' image on a 'perfect' display with 'perfect' compression is not directly relevant to the present situation with severely limited channel capacity. Rather than studying perceptually lossless compression we must carry out research to determine what types of lossy transformations are least disturbing to the human observer. Transmission of 'perfect', lossless images will not be practical for many years.
Effects of drag reducing polymer (1990)

In order to determine the effect of drag reducing polymers on the occurrence of atherosclerosis, the Guinea pigs were used as the experimental animals. The inhibitory effect of a drag reducing polymer (polyacrylamide) on atherosclerosis in the aortas of Guinea pigs on a high cholesterol diet (2%) was investigated over a period of 6 months. The aortas, livers, kidneys and lungs of the animals, which were separated into four experimental groups (control, polymer, cholesterol and cholesterol + polymer) were also investigated both macroscopically and light microscopically. The selected physiological parameters such as, plasma cholesterol levels, plasma hemoglobin, hematocrit and total lipid values were determined at regular intervals for each group. The results indicate that the atherosclerosis in aorta of the animals receiving the polymer injection is suppressed significantly and the drag reducing water soluble polymers may be effectively applied against atherosclerosis.
Unconditional security at a low cost (2006)

By simulating four quantum key distribution (QKD) experiments and analyzing one decoy-state QKD experiment, we compare two data post-processing schemes based on security against individual attack by Lütkenhaus, and unconditional security analysis by Gottesman-Lo-Lütkenhaus-Preskill. Our results show that these two schemes yield close performances. Since the Holy Grail of QKD is its unconditional security, we conclude that one is better off considering unconditional security, rather than restricting to individual attacks.
Image-based Representations for Accelerated Rendering of Complex Scenes (2005)

This paper gives an overview of image-based representations commonly used for reducing the geometric complexity of a scene description in order to accelerate the rendering process. Several different types of representations and ways for using them have been presented, which are classified and discussed here. Furthermore, the overview includes techniques for accelerating the rendering of static scenes or scenes with animations and/or dynamic lighting effects. The advantages and drawbacks of the different approaches are illuminated, and unsolved problems and roads for further research are shown.
Channel estimation for OFDM systems with multiple transmit antennas by filtering in time and frequency (2003)

We address pilot-symbol aided channel estimation (PACE) for orthogonal frequency division multiplexing (OFDM) based systems, with multiple transmit antennas. An approach is presented which estimates and separates N/sub T/ superimposed signals, corresponding to N/sub T/ transmit antennas, in two dimensions. More specifically, we extend the concept of using two one dimensional (1D) estimators, instead of a truly two dimensional (2D) estimator for MIMO-OFDM systems, by dividing the estimation as well as the separation task into two stages. Each estimator only separates a subset of the N/sub T/ superimposed signals, together with smoothing and interpolation in the respective dimension. Design rules for the optimization of the proposed 2/spl times/1D estimator are established, dependent on the performance, computational complexity, induced delay, and overhead due to pilot symbols.
A scenario-driven role engineering process for functional RBAC roles (2002)

In this paper we present a novel scenario-driven role engineering process for RBAC roles. The scenario concept is of central significance for the presented approach. Due to the strong human factor in role engineering scenarios are a good means to drive the process. We use scenarios to derive permissions and to define tasks. Our approach considers changeability issues and enables the straightforward incorporation of changes into affected models. Finally we discuss the experiences we gained by applying the scenario-driven role engineering process in three case studies.
An Incremental Process Mining Approach to Extract Knowledge from Legacy Systems (2010)

Several approaches have already been proposed to extract both business processes and business rules from a legacy source code. These approaches consider static source code analysis for the extraction procedure. However, business processes have components that can not be directly extracted by static analysis (i.e., participants, responsibilities, and concurrent activities). Moreover, well-known static analysis algorithms do not support the incremental extraction of information from the legacy code. Large legacy systems can benefit from an incremental analysis strategy in order to provide iterative information extraction as well as to achieve partial results much earlier. This paper discusses a new approach for business knowledge extraction from legacy systems. The approach considers an incremental process mining technique to extract business process structures and the business rules associated to it. Discovery results can be used in various ways by business analysts and software architects, e.g. documentation of legacy systems or for re-engineering purposes.
Agrobacterium tumefaciens virE operon encodes a single-stranded DNA-binding protein. (1988)

The virulence (vir) genes of Agrobacterium tumefaciens Ti plasmid are essential for transformation of plant cells. Overproduction of a virE-encoded gene product in Escherichia coli was achieved by construction of an operon fusion with the E. coli tryptophan (trp) operon. The virE2 gene product in E. coli partitioned into the insoluble membrane fraction. The protein was solubilized by treatment with 4 M urea at 0 degree C. DNA-protein binding experiments showed that a strong single-stranded (ss) DNA-binding activity was present in protein fractions containing the virE2 gene product. The binding was highly specific with little or no binding observed with either double-stranded DNA or ssRNA. No significant binding to Ti plasmid DNA sequences was observed. Protein blotting studies indicated that the ssDNA-binding activity was associated with the 68-kDa virE2 polypeptide.
O protestantismo entre os índios Palikúr do Rio Urucauá (Oiapoque, Brasil) (1980)

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