gebhart/patrepeval huggingface dataset:
Efficient test-point selection for scan-based BIST (1998)

We propose a test point selection algorithm for scan-based built-in self-test (BIST). Under a pseudorandom BIST scheme, the objectives are (1) achieving a high random pattern fault coverage, (2) reducing the computational complexity, and (3) minimizing the performance as well as the area overheads due to the insertion of test points. The proposed algorithm uses a hybrid approach to accurately estimate the profit of the global random testability of a test point candidate. The timing information is fully integrated into the algorithm to access the performance impact of a test point. In addition, a symbolic procedure is proposed to compute testability measures more efficiently for circuits with feedbacks so that the test point selection algorithm can be applied to partial-scan circuits. The experimental results show the proposed algorithm achieves higher fault coverages than previous approaches,with a significant reduction of computational complexity. By taking timing information into consideration, the performance degradation can he minimized with possibly more test points.
A Prospective, Nonrandomized, Open-Labeled Pilot Study Investigating the Use of Magnesium in Patients Undergoing Nonacute Percutaneous Coronary Intervention with Stent Implantation (2003)

Intravenous magnesium sulfate has been demonstrated as a feasible and safe agent in patients undergoing nonacute percutaneous coronary intervention with stent implantation. A randomized clinical trial comparing magnesium with glycoprotein inhibitors during percutaneous coronary intervention is warranted.
Novel multistep BRET-FRET energy transfer using nanoconjugates of firefly proteins, quantum dots, and red fluorescent proteins (2013)

Sequential bioluminescence resonance energy transfer (BRET) and fluorescence resonance energy transfer (FRET) from firefly luciferase to red fluorescent proteins using quantum dot or rod acceptor/donor linkers is described. The effect of morphology and tuned optical properties on the efficiency of this unique BRET-FRET system was evaluated.
Response of Aphid-Tending Ants to a Repellent Produced by Wasps (Hymenoptera: Formicidae, Vespidae) (1989)

Journal Article Response of Aphid-Tending Ants to a Repellent Produced by Wasps (Hymenoptera: Formicidae, Vespidae) Get access Gregg Henderson, Gregg Henderson 1Department of Entomology, University of Wisconsin, Madison, Wisconsin 53706. Search for other works by this author on: Oxford Academic Google Scholar Robert L. Jeanne Robert L. Jeanne 1Department of Entomology, University of Wisconsin, Madison, Wisconsin 53706. Search for other works by this author on: Oxford Academic Google Scholar Annals of the Entomological Society of America, Volume 82, Issue 4, 1 July 1989, Pages 516–519, https://doi.org/10.1093/aesa/82.4.516 Published: 01 July 1989 Article history Received: 15 August 1988 Accepted: 17 October 1988 Published: 01 July 1989
NDX: Neutron Dose Rate Meters with Extended Capabilities (2019)

The novel design of the neutron moderator for the NDX dose rate meter implements a layer of a Beryllium-loaded medium Z material which allows the device to detect higher energy neutron flux and convert it to dose. Using Beryllium helps to fill the known dip in the response functions around 5-50 MeV. Optimized design parameter set, obtained using FLUKA Monte Carlo simulations, features the NDX moderator made of polyethylene embedding a layer of Be-Cu alloy inside, with the dose rate response constant within ±10% in the neutron energy range from about 100 keV to 500 MeV, and ±25% essentially in the full energy range above thermal. A new sensor technique implemented in the NDX is based on using the Ionization Chamber (IC) filled with <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> He gas to capture the moderated neutron fluence, and includes a symmetric IC filled with regular <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> He to evaluate the contributions due to the non-neutron ionizing radiation. Advantages of the method include large accessible dynamic range, relative insensitivity of the IC probes to photon radiation fields, and the ability to subtract their contribution. Two prototype NDX detectors were built, calibrated, and operated in various conditions at the CEBAF 12 GeV electron accelerator at JLab. The first results showed reliable neutron dose rate measurements in the presence of overwhelming photon radiation fields, and at practical high dose rate levels of up to approximately 10 Sv/h. Detector design, operation, first results, and further development plans are presented.
Design and Characterization of High-Bandwidth, Resonance Enhanced Pulsed Microactuators: A Parametric Study (2012)

An extensive study on a microactuator that can generate high-momentum, high-frequency perturbations over a large bandwidth is presented in this paper. Such an actuator can potentially be used for the active control of various shear and boundary-layer flows that involve separation, mixing, and noise generation. The resonance enhanced microjet actuator described in this paper is a simple microfluidic system consisting of an underexpanded source jet flowing into a specially configured cavity integrated with multiple micronozzles, through which unsteady pulsed supersonic jets issue. The resonance frequency of these microjets could be varied over a large range (approximately 1–60 kHz) by changing the geometric and flow parameters of the microactuator system. Mean and unsteady properties of the microactuator are examined, including time-resolved flow visualizations and synchronous pressure and noise measurements; collectively, they provide a better understanding of the actuator dynamics. The present study also explores the design space and performance, as well as some of the design limitations of this actuator. Based on this parametric, a correlation is suggested that may be used for designing such actuators for various applications.
T cell engaging bispecific antibodies targeting CD33 IgV and IgC domains for the treatment of acute myeloid leukemia (2021)

These data support further clinical development of this BsAb for first-in-human phase I clinical trial.
Optical limiting with complex plasmonic nanoparticles (2010)

Optical limiting by suspensions of Au nanoparticles is enhanced by several orders of magnitude with the use of complex plasmonic shapes, such as spined 'nanourchins,' instead of nanospheres. Similar enhancements are observed by changing the material of nanospheres from Au to Ag. The experiments, measuring intensity-dependent transmission over a wavelength range from 450 to 650 nm for a 6 ns pulsed laser, are analyzed in terms of an effective nonlinear extinction coefficient, which we relate to the local, plasmonically enhanced electric field. FDTD simulations reveal a large electric field enhancement inside the nanospined structures and qualitatively confirm the plasmonic trends, where Ag nanospheres and Au nanourchins are more effective than Au nanospheres. These results suggest that designing nanostructures for the maximum plasmonic enhancement provides a roadmap to materials and geometries with optimized optical limiting behavior.
Porous solgel fiber as a transducer for highly sensitive chemical sensing (2002)

A novel solgel process for making porous silica fiber and doping the fiber core with sensing material is described. A CoCl(2) -doped solgel fiber was fabricated and was used to construct an active-core optical fiber moisture sensor. Test results show that the sensitivity of the active-core optical fiber sensor is much higher than that of an evanescent-wave-based optical fiber sensor.
Chasing Equilibrium:  Measuring the Intrinsic Solubility of Weak Acids and Bases (2005)

A novel procedure is described for rapid (20-80 min) measurement of intrinsic solubility values of organic acids, bases, and ampholytes. In this procedure, a quantity of substance was first dissolved at a pH where it exists predominantly in its ionized form, and then a precipitate of the neutral (un-ionized) species was formed by changing the pH. Subsequently, the rate of change of pH due to precipitation or dissolution was monitored and strong acid and base titrant were added to adjust the pH to discover its equilibrium conditions, and the intrinsic solubility of the neutral form of the compound could then be determined. The procedure was applied to a variety of monoprotic and diprotic pharmaceutical compounds. The results were highly repeatable and had a good correlation to available published values. Data collected during the procedure provided good diagnostic information. Kinetic solubility data were also collected but provided a poor guide to the intrinsic solubility.
Detection and Quantification of the Fragile X Mental Retardation Protein 1 (FMRP) (2016)

The final product of <i>FMR1</i> gene transcription, Fragile X Mental Retardation Protein 1 (FMRP), is an RNA binding protein that acts as a repressor of translation. FMRP is expressed in several tissues and plays important roles in neurogenesis, synaptic plasticity, and ovarian functions and has been implicated in a number of neuropsychological disorders. The loss of FMRP causes Fragile X Syndrome (FXS). In most cases, FXS is due to large expansions of a CGG repeat in <i>FMR1</i>-normally containing 6-54 repeats-to over 200 CGGs and identified as full mutation (FM). Hypermethylation of the repeat induces <i>FMR1</i> silencing and lack of FMRP expression in FM male. Mosaic FM males express low levels of FMRP and present a less severe phenotype that inversely correlates with FMRP levels. Carriers of pre-mutations (55-200 CGG) show increased mRNA, and normal to reduced FMRP levels. Alternative splicing of <i>FMR1</i> mRNA results in 24 FMRP predicted isoforms whose expression are tissues and developmentally regulated. Here, we summarize the approaches used by several laboratories including our own to (a) detect and estimate the amount of FMRP in different tissues, developmental stages and various pathologies; and (b) to accurately quantifying FMRP for a direct diagnosis of FXS in adults and newborns.
<i>o</i>-Methoxy Substituents in Spiro-OMeTAD for Efficient Inorganic–Organic Hybrid Perovskite Solar Cells (2014)

Three spiro-OMeTAD derivatives have been synthesized and characterized by (1)H/(13)C NMR spectroscopy and mass spectrometry. The optical and electronic properties of the derivatives were modified by changing the positions of the two methoxy substituents in each of the quadrants, as monitored by UV-vis spectroscopy and cyclic voltammetry measurements. The derivatives were employed as hole-transporting materials (HTMs), and their performances were compared for the fabrication of mesoporous TiO2/CH3NH3PbI3/HTM/Au solar cells. Surprisingly, the cell performance was dependent on the positions of the OMe substituents. The derivative with o-OMe substituents showed highly improved performance by exhibiting a short-circuit current density of 21.2 mA/cm(2), an open-circuit voltage of 1.02 V, and a fill factor of 77.6% under 1 sun illumination (100 mW/cm(2)), which resulted in an overall power conversion efficiency (PCE) of 16.7%, compared to ~15% for conventional p-OMe substituents. The PCE of 16.7% is the highest value reported to date for perovskite-based solar cells with spiro-OMeTAD.
A General Strategy to Disperse and Functionalize Carbon Nanotubes Using Conjugated Block Copolymers (2008)

Abstract A general strategy to disperse and functionalize pristine carbon nanotubes in a single‐step process is developed using conjugated block copolymers. The conjugated block copolymer contains two blocks: a conjugated polymer block of poly(3‐hexylthiophene), and a functional non‐conjugated block with tunable composition. When the pristine carbon nanotubes are sonicated with the conjugated block copolymers, the poly(3‐hexylthiophene) blocks bind to the surface of de‐bundled carbon nanotubes through non‐covalent π – π interactions, stabilizing the carbon nanotube dispersion, while the functional blocks locate at the outer surface of carbon nanotubes, rendering the carbon nanotubes with desired functionality. In this paper, conjugated block copolymers of poly(3‐hexylthiophene)‐ b ‐poly(methyl methacrylate), poly(3‐hexylthiophene)‐ b ‐poly(acrylic acid), and poly(3‐hexylthiophene)‐ b ‐poly(poly(ethylene glycol) acrylate) are used to demonstrate this general strategy.
Genetic variants for prediction of gestational diabetes mellitus and modulation of susceptibility by a nutritional intervention based on a Mediterranean diet (2022)

We identify a core set of SNPs in their association with diabetes and GDM in a large cohort of patients from two main ethnicities from a single center. Identification of these genetic variants, even in the setting of a nutritional intervention, deems useful to design preventive and therapeutic strategies.
Lateral Flow Dipstick Test for Serodiagnosis of Strongyloidiasis (2019)

The conventional method of detecting <i>Strongyloides stercoralis</i> in fecal samples has poor diagnostic sensitivity. Detection of <i>Strongyloides</i>-specific antibodies increases the sensitivity; however, most tests are ELISAs that use parasite extract which may cross-react with the sera of other helminth infections. To improve the serological diagnosis of strongyloidiasis, this study aimed at developing a sensitive and specific lateral flow rapid dipstick test. Two recombinant proteins, recombinant NIE (rNIE) and recombinant Ss1a (rSs1a), were used in preparing the dipstick, with gold-conjugated antihuman IgG4 as detector reagent. In parallel, the corresponding ELISA was performed. Both assays demonstrated diagnostic sensitivity of 91.3% (21/23) when tested with serum samples of patients with <i>Strongyloides</i> infection, and 100% specificity with 82 sera of asymptomatic (healthy) and those with other parasitic infections. The ELISA and dipstick test results were positively correlated to each other (<i>r</i> = 0.6114, <i>P</i> = 0.0019). The developed lateral flow dipstick test may improve the serodiagnosis of strongyloidiasis and merit further validation studies.
Study on solid material of starch syrup produced by extruded corn starch added enzyme preparation (2009)

This paper studied the influence of main parameters of extruder-liquefication and saccharification(barrel temperature,enzyme content during extrusion,time of liquefication,enzyme content during liquefaction and enzyme content during saccharification) on solid material of starch syrupy produced by extruded corn raw starch in laboratory.Appling the method of quadratic orthogonal rotation combination test design of five factors and five levels(1/2 implementation) and Reda software to analyze the experimental data,the regression equation was got.The best ranges of parametes of solid material containing more than 35% were as followings:barrel temperature was 69.1-70.9 ℃,enzyme content during extrusion was 0.865-0.919 L·t-1,time of liquefication was 17.05-17.95 min,enzyme content during liquefaction was 0.602-0.634 L·t-1 and enzyme content during saccharification was 1.8125-1.95 L·t-1.
Genome Sequence of a Novel, Newly Identified Isolate of Guinea Pig Cytomegalovirus, the CIDMTR Strain (2013)

The sequence of a newly discovered isolate of guinea pig cytomegalovirus (GPCMV), the CIDMTR strain, was determined. The 232,778-nucleotide genome was generally well conserved with that of the 22122 reference strain, although some regions of substantial sequence divergence allowed annotation of strain-specific open reading frames encoding putative immune modulation gene products.
Activation of the Proapoptotic Bcl-2 Protein Bax by a Small Molecule Induces Tumor Cell Apoptosis (2014)

The proapoptotic Bcl-2 protein Bax by itself is sufficient to initiate apoptosis in almost all apoptotic paradigms. Thus, compounds that can facilitate disruptive Bax insertion into mitochondrial membranes have potential as cancer therapeutics. In our study, we have identified small-molecule compounds predicted to associate with the Bax hydrophobic groove by a virtual-screen approach. Among these, one lead compound (compound 106) promotes Bax-dependent but not Bak-dependent apoptosis. Importantly, this compound alters Bax protein stability in vitro and promotes the insertion of Bax into mitochondria, leading to Bax-dependent permeabilization of the mitochondrial outer membrane. Furthermore, as a single agent, compound 106 inhibits the growth of transplanted tumors, probably by inducing apoptosis in tumors. Our study has revealed a compound that activates Bax and induces Bax-dependent apoptosis, which may lead to the development of new therapeutic agents for cancer.
EIT-Based Photonic Crystals and Photonic Logic Gate Design (2012)

advantage of the effect of such an optical switching control. In Sec. 9 we close the chapter with some concluding remarks.
Xenobiotic induction of esterases in cultures of the yeast‐like symbiont from the cigarette beetle (1989)

Abstract By using the 1‐naphthyl acetate assay system, we found that xenobiotics can induce increased esterase activity in cultures of the yeast‐like symbiont, Symbiotaphrina kochii Jurzitza ex. W. Gams and v. Arx, of the cigarette beetle, Lasioderma serricorne L., The activities expressed as percent of solvent control are as follows: flavone, 184.2%; griseofulvin, 115.8%; cis (‐)‐ß‐pinene, 111.4%; and malathion, 114.0%. Gel electrophoresis showed new enzymes are induced by three of the compounds tested. Thus, the yeast responds in a manner consistent with detoxification enzyme regulation common in insects and microorganisms. Résumé Induction xénobiotique d'estérases dans des cultures de symbiontes du type levure de Lasioderma serricorne En utilisant une méthode de dosage avec le 1‐naphtyle‐acétate, nous avons trouvé que des substances xénobiotiques peuvent induire une augmentation de l'activité estérase dans des cultures du symbionte de type levure, Symbiotaphrina kochii Jurzitza, ex W. Gams & v. Arx, de L. serricorne. Le solvant ayant servi de témoin, a constitué la référence à partir de laquelle ont été calculés les pourcentages obtenus: flavone 184,2%; griséofluvine, 115,8%; cis (‐)‐ß‐pinène, 111,4%; malathion, 114,0%. L'électrophorèse sur gel de polyacrylamine a montré que les nouvelles enzymes sont induites par 3 des substances examinées. Ainsi, la levure réagit d'une façon compatible avec la régulation enzymatique de la détoxification commune aux insectes et aux microorganismes.
Transform-Data-by-Example (TDE) (2018)

Business analysts and data scientists today increasingly need to clean, standardize and transform diverse data sets, such as name, address, date time, phone number, etc., before they can perform analysis. These ad-hoc transformation problems are typically solved by one-off scripts, which is both difficult and time-consuming.
Percutaneous transluminal microwave balloon angioplasty (1990)

Microwave balloon angioplasty (MBA), which combines conventional balloon angioplasty techniques with microwave heating to help enlarge the lumen of narrowed arteries and reduce the occurrence of restenosis, is discussed. An apparatus for the delivery of MBA using 2450 MHz heating power is described. Using this apparatus, local arterial wall temperatures as higher 90 degrees C were obtained during MBA on anesthetized rabbits. Tissue modification of the arterial walls due to simultaneous ballooning and heating was observed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis (2015)

Semaphorins play important regulatory roles in diverse processes such as axon guidance, angiogenesis, and immune responses. We find that semaphorin-3C (sema3C) induces the collapse of the cytoskeleton of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1-dependent manner, while most other semaphorins, including antiangiogenic semaphorins such as sema3A do not. Sema3C is cleaved, like other class-3 semaphorins, by furin-like pro-protein convertases (FPPC). Cleaved sema3C (p65-Sema3C) was unable to induce the collapse of the cytoskeleton of LEC. FPPC are strongly upregulated in tumor cells. In order to examine the effects of full-length sema3C on tumor progression, we therefore generated an active point mutated furin cleavage-resistant sema3C (FR-sema3C). FR-sema3C inhibited potently proliferation of LEC and to a lesser extent proliferation of human umbilical vein-derived endothelial cells. FR-sema3C also inhibited VEGF-C-induced phosphorylation of VEGFR-3, ERK1/2, and AKT. Expression of recombinant FR-sema3C in metastatic, triple-negative LM2-4 breast cancer cells did not affect their migration or proliferation in vitro. However, tumors derived from FR-sema3C-expressing LM2-4 cells implanted in mammary fat pads developed at a slower rate, contained a lower concentration of blood vessels and lymph vessels, and metastasized much less effectively to lymph nodes. Interestingly, p65-Sema3C, but not FR-sema3C, rendered A549 lung cancer cells resistant to serum deprivation, suggesting that previously reported protumorigenic activities of sema3C may be due to p65-Sema3C produced by tumor cells. Our observations suggest that FR-sema3C may be further developed into a novel antitumorigenic drug.
Constraining the phrase-based, joint probability statistical translation model (2006)

The joint probability model proposed by Marcu and Wong (2002) provides a strong probabilistic framework for phrase-based statistical machine translation (SMT). The model's usefulness is, however, limited by the computational complexity of estimating parameters at the phrase level. We present the first model to use word alignments for constraining the space of phrasal alignments searched during Expectation Maximization (EM) training. Constraining the joint model improves performance, showing results that are very close to state-of-the-art phrase-based models. It also allows it to scale up to larger corpora and therefore be more widely applicable.
Bidirectional four-channel coherent transmission (1986)

Optical frequency multiplex systems with a very high number of broadband channels can be established, if coherent fiber-optic transmission techniques are used1 and the channels are demultiplexed by heterodyne receivers. We report a four-channel transmission experiment in the 820nm wavelength region.
Excitation of Epsilon‐Near‐Zero Mode in Optical Fiber (2023)

Abstract Experimental excitation of a highly confined epsilon‐near‐zero (ENZ) mode in a side‐polished optical fiber coated with a deep subwavelength thick layer of aluminum‐doped zinc oxide (AZO) is reported. The uniform AZO layer on the fiber is fabricated by atomic layer deposition technique and optimized to exhibit close‐to‐zero permittivity at the near‐infrared wavelength. Highly polarization‐ and wavelength‐dependent transmission with strong resonance strength up to 25 dB is observed in a 30‐nm ENZ‐coated fiber that is 17 mm long. Different from the excitation of the ENZ mode in a planar conducting oxide thin film, the hybrid ENZ mode can be excited via direct phase matching between the fundamental mode of the fiber and the ENZ mode supported by the AZO thin film. The hybrid ENZ mode in the fiber exhibits a relatively long propagation/light–matter interaction length which is a few orders of magnitude longer than those on the planar ENZ substrates. It is further shown that the hybrid resonance in the ENZ fiber can be actively tuned through the refractive index of surrounding medium and the large ENZ's nonlinearity. These ENZ‐optical fibers serve as emerging in‐fiber optical devices, such as advanced in‐fiber ultrafast optical switches/modulators, mode‐locked fiber lasers, and in‐fiber optical gas/biomolecule sensors.