gebhart/patrepeval huggingface dataset:
The n-PI-method for helical cone-beam CT (2000)

A new class of acquisition schemes for helical cone-beam computed tomography (CB-CT) scanning is introduced, and their effect on the reconstruction methods is analyzed. These acquisition schemes are based on a new detector shape that is bounded by the helix. It will be shown that the data acquired with these schemes are compatible with exact reconstruction methods, and the adaptation of exact reconstruction algorithms to the new acquisition geometry is described. At the same time, the so-called PI-sufficiency condition is fulfilled. Moreover, a good fit to the acquisition requirements of the various medical applications of cone-beam CT is achieved. In contrast to other helical cone-beam acquisition and reconstruction methods, the n-PI-method introduced in this publication allows for variable pitches of the acquisition helix. This additional feature will introduce a higher flexibility into the acquisition protocols of future medical cone-beam scanners. An approximative n-PI-filtered backprojection (n-PI-FBP) reconstruction method is presented and verified. It yields convincing image quality.
MobiCloud: Building Secure Cloud Framework for Mobile Computing and Communication (2010)

Cloud services can greatly enhance the computing capability of mobile devices. Mobile users can rely on the cloud to perform computationally intensive operations such as searching, data mining, and multimedia processing. In this paper, we propose a new mobile cloud framework called MobiCloud. In addition to providing traditional computation services, MobiCloud also enhances the operation of the ad hoc network itself by treating mobile devices as service nodes. The MobiCloud framework will enhance communication by addressing trust management, secure routing, and risk management issues in the network. A new class of applications can be developed using the enhanced processing power and connectivity provided by MobiCloud. Open research issues for MobiCloud are also discussed to outline future research directions.
4.5 GHz Lamb wave device composed of LiNbO<inf>3</inf> thin film (2009)

A high frequency device of 3 GHz or more is required, for instance, for future 4-th generation mobile phone system in Japan. Using a substrate with a high velocity is one method to realize a high frequency elastic device. A lamb wave has a high velocity when the substrate thickness normalized by a wavelength (lambda) of an elastic wave is thin. It is difficult to make a very thin crystal plate in order to realize a high frequency device. The authors have attempted to fabricate a lamb wave device using a c-axis orientated thin LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> film deposited by a chemical vapor deposition system (CVD). A lamb wave resonator composed of a interdigital transducer (IDT)/thin LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> film/air gap/base substrate has shown a high frequency of 4.5 GHz, which corresponds a high velocity of 14,000 m/s, and an excellent characteristics such as an impedance ratio of 52 dB and a wide band of 7.2%.
Acoustic response of a torsional shear wave transducer in a viscoelastic medium (1992)

Based on a previous design of a low-frequency, torsional shear wave transducer [A. K. Walden and T. R. Howarth, J. Acoust. Soc. Am. 91, 2463 (1992)], an analytical model is proposed to predict the radiated acoustic field. The stress and displacement fields produced by the S-wave source are analyzed with the appropriate boundary conditions. Then the continuity condition of the field (elastic wave equation) is employed to investigate the propagating subfields in the surrounding elastic/viscoelastic medium. The transducer studied is a cylindrical-type torsional vibrator. Therefore, it generates both horizontal and vertical radiation patterns. Computed, as well as measured results, of the acoustic response are presented for various couplings of different viscoelastic media with both the bimorph and torsional shear wave transducer designs. These results are useful for an optimal shear wave transducer design in the applications of ocean geoacoustics.
Label Disentanglement in Partition-based Extreme Multilabel Classification (2021)

Partition-based methods are increasingly-used in extreme multi-label classification (XMC) problems due to their scalability to large output spaces (e.g., millions or more). However, existing methods partition the large label space into mutually exclusive clusters, which is sub-optimal when labels have multi-modality and rich semantics. For instance, the label "Apple" can be the fruit or the brand name, which leads to the following research question: can we disentangle these multi-modal labels with non-exclusive clustering tailored for downstream XMC tasks? In this paper, we show that the label assignment problem in partition-based XMC can be formulated as an optimization problem, with the objective of maximizing precision rates. This leads to an efficient algorithm to form flexible and overlapped label clusters, and a method that can alternatively optimizes the cluster assignments and the model parameters for partition-based XMC. Experimental results on synthetic and real datasets show that our method can successfully disentangle multi-modal labels, leading to state-of-the-art (SOTA) results on four XMC benchmarks.
Performances of advanced infrared pyroelectric detectors (1990)

This paper shows the advantages of thermal imaging using ferroelectric materials like ceramics and polymers. Their pyroelectric and dielectric properties lead to built uncooled infra-red detectors with high thermal resolution (NETD<0.2 K). The pyroelectric charges due to the absorption of the thermal IR image are readout by an electron beam in a pyricon tube or by a charge transfert circuit in an IR-CCD device
Attenuation of and Protection Induced by a Leucine Auxotroph of<i>Mycobacterium tuberculosis</i> (2000)

Attenuated mutants of Mycobacterium tuberculosis represent potential vaccine candidates for the prevention of tuberculosis. It is known that auxotrophs of a variety of bacteria are attenuated in vivo and yet provide protection against challenge with wild-type organisms. A leucine auxotroph of M. tuberculosis was created by allelic exchange, replacing wild-type leuD (Rv2987c), encoding isopropyl malate isomerase, with a mutant copy of the gene in which 359 bp had been deleted, creating a strain requiring exogenous leucine supplementation for growth in vitro. The frequency of reversion to prototrophy was <10(-11). In contrast to wild-type M. tuberculosis, the DeltaleuD mutant was unable to replicate in macrophages in vitro. Its attenuation in vivo and safety as a vaccine were established by the fact that it caused no deaths in immunodeficient SCID mice. Complementation of the mutant with wild-type leuD abolished the requirement for leucine supplementation and restored the ability of the strain to grow both in macrophages and in SCID mice, thus confirming that the attenuated phenotype was due to the DeltaleuD mutation. As a test of the vaccine potential of the leucine auxotroph, immunocompetent BALB/c mice, susceptible to fatal infection with wild-type M. tuberculosis, were immunized with the DeltaleuD mutant and subsequently challenged with virulent M. tuberculosis by both the intravenous and aerosol routes. A comparison group of mice was immunized with conventional Mycobacterium bovis BCG vaccine. Whereas all unvaccinated mice succumbed to intravenous infection within 15 weeks, mice immunized with either BCG or the DeltaleuD mutant of M. tuberculosis exhibited enhanced and statistically equivalent survival curves. However, the leuD auxotroph was less effective than live BCG in reducing organ burdens and tissue pathology of mice challenged by either route. We conclude that attenuation and protection against M. tuberculosis challenge can be achieved with a leucine auxotroph and suggest that to induce optimal protection, attenuated strains of M. tuberculosis should persist long enough and be sufficiently metabolically active to synthesize relevant antigens for an extended period of time.
Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors (2019)

Rocaglates are a family of natural products isolated from the genus <i>Aglaia</i> which possess a highly substituted cyclopenta[<i>b</i>]benzofuran skeleton and inhibit cap-dependent protein synthesis. Rocaglates are attractive compounds due to their potential for inhibiting tumor cell maintenance <i>in vivo</i> by specifically targeting eukaryotic initiation factor 4A (eIF4A) and interfering with recruitment of ribosomes to mRNA. In this paper, we describe an intercepted retro-Nazarov reaction utilizing intramolecular tosyl migration to generate a reactive oxyallyl cation on the rocaglate skeleton. Trapping of the oxyallyl cation with a diverse range of nucleophiles has been used to generate over 50 novel amidino-rocaglate (ADR) and amino-rocaglate derivatives. Subsequently, these derivatives were evaluated for their ability to inhibit cap-dependent protein synthesis where they were found to outperform previous lead compounds including the rocaglate hydroxamate CR-1-31-B.
Building user-defined runtime adaptation routines for stream processing applications (2012)

Stream processing applications are deployed as continuous queries that run from the time of their submission until their cancellation. This deployment mode limits developers who need their applications to perform runtime adaptation, such as algorithmic adjustments, incremental job deployment, and application-specific failure recovery. Currently, developers do runtime adaptation by using external scripts and/or by inserting operators into the stream processing graph that are unrelated to the data processing logic. In this paper, we describe a component called orchestrator that allows users to write routines for automatically adapting the application to runtime conditions. Developers build an orchestrator by registering and handling events as well as specifying actuations. Events can be generated due to changes in the system state (e.g., application component failures), built-in system metrics (e.g., throughput of a connection), or custom application metrics (e.g., quality score). Once the orchestrator receives an event, users can take adaptation actions by using the orchestrator actuation APIs. We demonstrate the use of the orchestrator in IBM's System S in the context of three different applications, illustrating application adaptation to changes on the incoming data distribution, to application failures, and on-demand dynamic composition.
<i>TERT</i> Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine (2013)

Activating mutations occur in the promoter of the telomerase reverse transcriptase (TERT) gene in 66% of muscle-invasive urothelial carcinomas. To explore their role in bladder cancer development and to assess their utility as urine markers for early detection, we sequenced the TERT promoter in 76 well-characterized papillary and flat noninvasive urothelial carcinomas, including 28 pTa low-grade transitional cell carcinomas (TCC), 31 pTa high-grade TCCs, and 17 pTis carcinoma in situ lesions. We also evaluated the sequence of the TERT promoter in a separate series of 14 early bladder neoplasms and matched follow-up urine samples to determine whether urine TERT status was an indicator of disease recurrence. A high rate of TERT promoter mutation was observed in both papillary and flat lesions, as well as in low- and high-grade noninvasive urothelial neoplasms (mean: 74%). In addition, among patients whose tumors harbored TERT promoter mutations, the same mutations were present in follow-up urines in seven of eight patients that recurred but in none of the six patients that did not recur (P < 0.001). TERT promoter mutations occur in both papillary and flat lesions, are the most frequent genetic alterations identified to date in noninvasive precursor lesions of the bladder, are detectable in urine, and seem to be strongly associated with bladder cancer recurrence. These provocative results suggest that TERT promoter mutations may offer a useful urinary biomarker for both early detection and monitoring of bladder neoplasia.
A synthetic polymer system with repeatable chemical recyclability (2018)

The development of chemically recyclable polymers offers a solution to the end-of-use issue of polymeric materials and provides a closed-loop approach toward a circular materials economy. However, polymers that can be easily and selectively depolymerized back to monomers typically require low-temperature polymerization methods and also lack physical properties and mechanical strengths required for practical uses. We introduce a polymer system based on γ-butyrolactone (GBL) with a trans-ring fusion at the α and β positions. Such trans-ring fusion renders the commonly considered as nonpolymerizable GBL ring readily polymerizable at room temperature under solvent-free conditions to yield a high-molecular weight polymer. The polymer has enhanced thermostability and can be repeatedly and quantitatively recycled back to its monomer by thermolysis or chemolysis. Mixing of the two enantiomers of the polymer generates a highly crystalline supramolecular stereocomplex.
Seismic performance improvement of GFRP-RC moment frames (2019)

Although structures made of concrete reinforced with fiber-reinforced polymers (FRP) have shown promising performance under gravity loads, their performance under cyclic loading is still one of the main concerns. Although the linear nature of FRP reinforcement could be advantageous in terms of limiting the residual damage after an earthquake event, it lowers the energy dissipation of the structure, which can compromise its seismic performance. In this research, adding steel plates at selected locations in moment-resisting frames is proposed as a solution to improve seismic performance of FRP-reinforced concrete (FRP-RC) structures. Three full-scale cantilever beams, one steel-RC, one FRP-RC, and one FRP-RC with proposed steel plates, were constructed and tested under reversed cyclic loading. The results indicated that the proposed mechanism effectively improves the seismic performance of FRP-RC beams by increasing their initial stiffness and energy dissipation. Moreover, a computer simulation, using the moment–curvature determination process, was conducted to calculate bending moment capacity of FRP-RC beams with steel plates.
Quincy (2009)

This paper addresses the problem of scheduling concurrent jobs on clusters where application data is stored on the computing nodes. This setting, in which scheduling computations close to their data is crucial for performance, is increasingly common and arises in systems such as MapReduce, Hadoop, and Dryad as well as many grid-computing environments. We argue that data-intensive computation benefits from a fine-grain resource sharing model that differs from the coarser semi-static resource allocations implemented by most existing cluster computing architectures. The problem of scheduling with locality and fairness constraints has not previously been extensively studied under this resource-sharing model.
Establishment of macrocyclic lactone resistant Dirofilaria immitis isolates in experimentally infected laboratory dogs (2014)

These experimental infection studies provide in vivo evidence of the existence of ML drug resistance in dogs infected by D. immitis L3 from suspect field LOE cases in the Lower Mississippi Delta. Results encourage further work on mechanisms underlying the emergence of ML resistance in D. immitis and development of evidence-based resistance management strategies for heartworm preventives in order to extend the useful life of current drugs.
Ultrasonic cure and temperature monitoring of photoresist during the pre-exposure bake process (1998)

A system of in situ ultrasonic sensors has been developed that can be used to monitor the photoresist prebake process. A high frequency phase measurement monitors the resist film properties while a lower frequency time of flight measurement monitors the corresponding wafer temperature. The high frequency measurement involves calculating the phase of an ultrasound signal as it is reflected from the silicon/photoresist interface. As the photoresist film changes in thickness and viscoelastic properties, the phase of the reflected signal will change. In this way, it is possible to follow how the photoresist film changes as it bakes; the solvent evaporates from the resist, decreasing the thickness and increasing the density. Results indicate that there is a phase minimum at a repeatable temperature, believed to be the softening or glass transition temperature (T<SUB>g</SUB>). The lower frequency (200 kHz) time of flight measurement employs PZT-5H piezoelectric transducers bonded to a quartz buffer rod. The transducer generates a Lamb wave in the wafer which is then detected at another location by an identical transducer. The time of flight of the Lamb wave through the wafer depends linearly on temperature. Using these two sensors, we can measure the wafer temperature and the photoresist properties during prebake; providing us with the information necessary for in situ process control.
Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. (1995)

We employed homologous recombination in mouse embryonic stem cells to disrupt the estrogen receptor (ER) gene. Subsequently generated mice that are homozygous for the gene disruption, termed ERKO, possess no demonstrable wild-type ER by Western blot analysis. However, the presence of residual high affinity binding, as detected by [3H]estradiol binding assays and sucrose gradients in uterine extracts from ERKO females prompted further investigation of transcription and translation products from the disrupted ER gene. Analysis of ERKO uterine messenger RNA (mRNA) by reverse transcriptase-polymerase chain reaction demonstrated that although no full-length wild-type ER mRNA was present, two smaller transcripts, labeled E1 and E2, were identified and partially sequenced. Both ERKO transcripts are splicing variants that result in the disrupting NEO sequence being partially or completely removed from the mRNA. In the ERKO-E2 variant, this results in a frame shift and the creation of at least two stop codons downstream. In the ERKO-E1 variant, the ER reading frame is preserved and encodes for a smaller mutant ER that could be the source of the residual estradiol binding. When this mutant form is overexpressed and characterized in vitro, it results in a smaller protein of the predicted size that possesses significantly reduced estrogen-dependent transcriptional activity compared with that of the wild-type ER. Despite residual amounts of an impaired ER variant, estrogen insensitivity in the female ERKOs was confirmed by the failure of estrogen treatment to induce known uterine markers of estrogen action, such as increased DNA synthesis, and transcription of the progesterone receptor, lactoferrin, and glucose-6-phosphate dehydrogenase genes. Furthermore, serum levels of estradiol in the ERKO female are more than 10-fold higher than those in the wild type, consistent with a syndrome of hormone insensitivity.
Efficient robust AMF using the FRACTA algorithm (2005)

The FRACTA algorithm has been shown to be an effective space-time adaptive processing (STAP) methodology for the airborne radar configuration in which there exists nonhomogeneous clutter, jamming, and dense target clusters. Further developments of the FRACTA algorithm are presented here in which the focus is on the robust, efficient implementation of the FRACTA algorithm. Enhancements to the FRACTA algorithm include a censoring stopping mechanism, an alternative data blocking approach for adaptive power residue (APR) censoring, and a fast reiterative censoring (RC) procedure. Furthermore, a coherent processing interval (CPI) segmentation scheme for computing the adaptive weights is presented as an alternative approach to computing the adaptive matched filter (AMF) weight vector that allows for lower sample support and reduced computational complexity. The enhanced FRACTA algorithm, denoted as FRACTA.E, is applied to the KASSPER I challenge datacube which possesses dense ground target clusters that are known to have a significant deleterious effect on standard adaptive matched filtering (AMF) processors. It is shown that the FRACTA.E algorithm outperforms and is considerably more computationally efficient than both the original FRACTA algorithm and the standard sliding window processing (SWP) approach. Furthermore, using the KASSPER I datacube, the FRACTA.E algorithm is shown to have the same detection performance as the clairvoyant algorithm where the exact range-dependent clutter covariance matrices are known.
First Demonstration of 2µm Data Transmission in a Low-Loss Hollow Core Photonic Bandgap Fiber (2012)

The first demonstration of a hollow core photonic bandgap fiber suitable for high-rate data transmission at 2µm is presented. Using a custom built Thulium doped fiber amplifier, error-free 8Gbit/s transmission in an optically amplified data channel at 2008nm is reported for the first time.
Assessment of F/HN-Pseudotyped Lentivirus as a Clinically Relevant Vector for Lung Gene Therapy (2012)

The data support F/HN-pseudotyped SIV as a promising vector for pulmonary gene therapy for several diseases including CF. We are now undertaking the necessary refinements to progress this vector into clinical trials.
A physico-chemical investigation of fluorine-enriched quinolines (2018)

A homogenous series of 2,4-bis(fluoroalkyl)-substituted quinolines was synthesized under mild reaction conditions and their physico-chemical (absorption and emission, electrochemistry, and TD-DFT) properties were thoroughly investigated.
Engineering of a sialic acid synthesis pathway in transgenic plants by expression of bacterial Neu5Ac‐synthesizing enzymes (2006)

Plants are a low-cost and contamination-free factory for the production of recombinant pharmaceutical proteins. However, plant-made pharmaceuticals differ from their mammalian homologues by the structure of their N-linked glycans. For instance, most mammalian glycoproteins harbour terminal sialic acids that control their half-life in the bloodstream. The absence of the whole sialylation machinery in plants is of major concern as non-sialylated plant-made pharmaceuticals may not perform at their full potential in humans, because of their removal from the circulation through the involvement of hepatic cell receptors. In this context, we have investigated the synthesis of N-acetylneuraminic acid (Neu5Ac) in the cytosol of plants by either the re-routing of the endogenous 3-deoxy-d-manno-2-octulosonic acid (Kdo) biosynthetic pathway or the expression of microbial Neu5Ac-synthesizing enzymes. In this paper, we demonstrate that the plant Kdo-8P synthase is not able to use N-acetyl d-mannosamine as a substrate, and thus re-routing of the Kdo pathway for the synthesis of Neu5Ac is not possible. Consequently, we expressed genes encoding Neu5Ac lyase from Escherichia coli and Neu5Ac synthase (neuB2) from Campylobacter jejuni in plants. These resulted in the production of functional enzymes in the cytosol, which in turn can catalyse the synthesis of Neu5Ac in vitro. Experiments were carried out on two models, Bright Yellow 2 (BY2) tobacco cells and Medicago sativa (alfalfa), the perennial legume crop.