gebhart/patrepeval huggingface dataset:
Functional Analysis of the Rat Insulin-Like Growth Factor I Gene and Identification of an IGF-I Gene Promoter (1992)

Insulin-like growth factor I (IGF-I) mediates many of the systemic growth-promoting effects of growth hormone and also functions as a locally acting growth stimulator. In mammals, IGF-I gene expression is complicated, as the gene is transcribed and processed into multiple mRNAs (ranging in length from less than 1 to nearly 7.5 kb) that encode at least two protein precursors. As a step toward understanding the regulation of IGF-I, we report the complete organization of the rat IGF-I gene, including identification of the structural determinants for all IGF-I mRNA species, and an initial functional analysis of its promoters. The gene is composed of 6 exons distributed over nearly 80 kb of chromosomal DNA and is structurally heterogeneous. Several transcription start sites were identified within IGF-I exons 1 and 2, adjacent to presumptive promoters 1 and 2, respectively, and at least three polyadenylation sites were mapped to exon 6. To test promoter function, fusion genes were constructed linking fragments of IGF-I DNA to a reporter plasmid. Chimeric genes containing at least 395 bp of DNA from the 5'-flanking region of exon 1 enhanced luciferase activity after transfection into the IGF-I-producing SK-N-MC cell line, while fusion plasmids containing up to 1,300 bp of DNA from the 5'-flanking region of exon 2 were inactive. Relative levels of IGF-I mRNAs containing exons 1 or 2 varied among different rat tissues, although in response to acute or chronic growth hormone treatment both classes of transcripts were induced coordinately in rat liver. These observations represent the first thorough characterization of a mammalian IGF-I gene, and provide a starting point for defining the mechanisms by which growth hormone and other trophic factors regulate IGF-I gene expression.
Osteogenic Differentiation Influences Stem Cell Migration Out of Scaffold-Free Microspheres (2009)

Complete bone regeneration of critical-size defects frequently fail because of the use of acellular bone substitutes and because of partially negative influences of artificial scaffolds. However, the supply of cells to critical-size defects is essential for the regeneration. Therefore, engineered scaffold-free tissues, with outgrowing cells that fill up spaces in the bony defect, are promising candidates for bone regeneration approaches. Here, we demonstrate such a scaffold-free tissue construct (microspheres) that, if osteogenic differentiated, mineralizes while maintaining the capability to let cells grow out of the united cell structure. A superior outgrowth capability of microspheres composed of human cord blood-derived unrestricted somatic stem cells compared with murine embryonic stem cells was found and a time-dependent reduction in outgrowth was evident in vitro. Even after 5 days of osteoinduction and strong mineralization, the cells migrate out of the microsphere. As migration of cells out of unrestricted somatic stem cell microspheres was also found in extracellular matrix gel, we suggest that cells would migrate also in vivo. Thus, microspheres could serve as the scaffold and the source of osteogenic cells in future bone regeneration approaches. Further, microspheres permit the precise administration of large amount of cells into an area of interest.
Magnetic Interactions in the High-Spin Iron(III) Oxooctaethylchlorinato Derivative [Fe(oxoOEC)(Cl)] and Its π-Cation Radical [Fe(oxoOEC<sup>•</sup>)(Cl)]SbCl<sub>6</sub> (2000)

The preparation and characterization of the beta-oxochlorin derivative [3,3,7,8,12,13,17,18-octaethyl-(3H)-porphin-2-onato(2-)]iron(III) chloride, [Fe(oxoOEC)(Cl)], and its pi-cation radical derivative [Fe(oxoOEC.)(Cl)]SbCl6 is described. Both compounds have been characterized by single-crystal X-ray structure determinations, IR, UV/vis/near-IR, and Mössbauer spectroscopies, and temperature-dependent magnetic susceptibility measurements. The macrocycles of [Fe(oxoOEC)(Cl)] and [Fe(oxoOEC.)(Cl)]SbCl6 are both saddled, and [Fe(oxoOEC.)(Cl)]-SbCl6 is slightly ruffled as well. [Fe(oxoOEC)(Cl)] shows a laterally shifted dimeric unit in the solid state, with a mean plane separation of 3.39 A and a lateral shift of 7.39 A. Crystal data for [Fe(oxoOEC)(Cl)]: triclinic, space group P1, Z = 2, a = 9.174(2) A, b = 13.522(3) A, c = 14.838(3) A, alpha = 95.79(3) degrees, beta = 101.46(2) degrees, gamma = 104.84(3) degrees. Upon oxidation, the inter-ring geometric parameters increase; the mean plane separation and the lateral shift of the dimeric unit of [Fe(oxoOEC.)(Cl)]SbCl6 are 4.82 and 8.79 A, respectively. Crystal data for [Fe(oxoOEC.)(Cl)]SbCl6: monoclinic, space group Cc, Z = 4, a = 19.8419(13) A, b = 10.027(2) A, c = 22.417(4) A, beta = 96.13(2) degrees. A broad near-IR absorption band appears at 1415 nm for the pi-cation radical, [Fe(oxoOEC.)(Cl)]SbCl6. Zero-field Mössbauer measurements at 4.2 K for both [Fe(oxoOEC)(Cl)] and [Fe(oxoOEC.)(Cl)]SbCl6 confirmed that the oxidation state of the iron atom did not change upon chemical oxidation. Solid-state magnetic susceptibility measurements for [Fe(oxoOEC.)(Cl)]SbCl6 resulted in a large temperature dependence of the magnetic moment that can best be fit with a model that includes a zero-field splitting parameter of D = 6 cm-1, antiferromagnetic intermolecular iron-iron coupling (2JFe-Fe = -0.14 cm-1), antiferromagnetic intramolecular iron-radical coupling (2JFe-r = -76 cm-1), and antiferromagnetic radical-radical coupling (2Jr-r = -13 cm-1).
Effect of Sulfadoxine-Pyrimethamine Resistance on the Efficacy of Intermittent Preventive Therapy for Malaria Control During Pregnancy (2007)

In areas in which 1 of 4 treatments with sulfadoxine-pyrimethamine fail in children by day 14, the 2-dose IPT with sulfadoxine-pyrimethamine regimen continues to provide substantial benefit to HIV-negative semi-immune pregnant women. However, more frequent dosing is required in HIV-positive women not using cotrimoxazole prophylaxis for opportunistic infections.
Simulation and production planning for manufacturing cells (1998)

Simulation is used to verify the feasibility of the design of manufacturing cells for a major automotive company. The cell design, which combines new and existing machines in a component manufacture, is presented, showing the difficulties that can result with such a system. Simply changing the layout (arranging machines into cells) could provide some benefits, but these benefits were offset by a high level of required investment. The reasons for the increased costs include poorly matched cycle times, machine downtimes, complex material handling and long changeovers. Improvements in machine and material handling designs were found to be necessary in order to increase cell performance and reduce investment to a feasible level.
An Aspect of Aesthetics in Human-Computer Communications: Pretty Windows (1985)

Aesthetics in user interfaces addresses font definitions, typesetting conventions, color combinations, graphics design considerations, high resolution for viewscreens, and the shapes of windows. Computer viewscreens are evolving into pictorial media, communicating information with visual immediacy. The more interesting interfaces make use of multiple windows, menus, icons, and other visual effects to waken and sustain user interest and effectiveness. A pretty window is a viewscreen window with the dimensions of a golden rectangle, a rectangle whose width and height form the golden ratio of Euclid. Psychologists believe golden rectangles are aesthetically more pleasing than arbitrary rectangles, and subjects tend to select them in preference to other rectangles in tests.
High-yield scalable graphene nanosheet production from compressed graphite using electrochemical exfoliation (2018)

Electrochemical exfoliation is a promising bulk method for producing graphene from graphite; in this method, an applied voltage drives ionic species to intercalate into graphite where they form gaseous species that expand and exfoliate individual graphene sheets. However, a number of obstacles have prevented this approach from becoming a feasible production route; the disintegration of the graphite electrode as the method progresses is the chief difficulty. Here we show that if graphite powders are contained and compressed within a permeable and expandable containment system, the graphite powders can be continuously intercalated, expanded, and exfoliated to produce graphene. Our data indicate both high yield (65%) and extraordinarily large lateral size (>30 μm) in the as-produced graphene. We also show that this process is scalable and that graphene yield efficiency depends solely on reactor geometry, graphite compression, and electrolyte transport.
Organometallic methylation of nicotine and nicotine N-oxide. Reaction pathways and racemization mechanisms (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganometallic methylation of nicotine and nicotine N-oxide. Reaction pathways and racemization mechanismsJeffrey I. Seeman, Henry V. Secor, Charles R. Howe, Charles G. Chavdarian, and Larry W. MorganCite this: J. Org. Chem. 1983, 48, 25, 4899–4904Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/jo00173a023https://doi.org/10.1021/jo00173a023research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The Touch and Concern Doctrine and the Restatement (Third) of Servitudes: A Tribute to Lawrence E. Berger (1998)

Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using two-color fluorescence (yellow, red) for cell surface staining combined with two-color fluorescence for the Ca2+ chelator indo-1 (violet, blue) we can demonstrate that CD8+UCHL1+ memory cells exhibit a 1,5-fold higher influx than the CD8+UCHL1- virgin cells. The same pattern was obtained when CD8 memory and virgin cells were defined by a reciprocal marker (Leu-18) indicating that the higher response of memory CD8 cells is independent of the monoclonal antibody used to identify the cells. For the respective CD4 subsets no such clear-cut pattern of Ca2+ influx was evident. Analysis of proliferation in both subsets indicates that CD8+UCHL1- cells strongly proliferate in response to PHA, while CD8+UCHL1+ memory cells show only a minimal response with the average cpm values being 6-fold lower. In some instances no proliferation at all was detectable in the CD8+UCHL1+ cells. Identification of the subsets by reciprocal markers confirmed the lower proliferative response in the CD8 memory cells. Hence, within the CD8 compartment the memory cells, after phytohemagglutinin stimulation, exhibit a high Ca2+ mobilization but a low to absent proliferation, while the converse is true for the naive cells. These data show that (a) Ca2+ mobilization and proliferation are inversely correlated and (b) an initially vigorous response of memory cells may be subject to negative control mechanisms.
Inductive Supervised Quantum Learning (2017)

In supervised learning, an inductive learning algorithm extracts general rules from observed training instances, then the rules are applied to test instances. We show that this splitting of training and application arises naturally, in the classical setting, from a simple independence requirement with a physical interpretation of being nonsignaling. Thus, two seemingly different definitions of inductive learning happen to coincide. This follows from the properties of classical information that break down in the quantum setup. We prove a quantum de Finetti theorem for quantum channels, which shows that in the quantum case, the equivalence holds in the asymptotic setting, that is, for large numbers of test instances. This reveals a natural analogy between classical learning protocols and their quantum counterparts, justifying a similar treatment, and allowing us to inquire about standard elements in computational learning theory, such as structural risk minimization and sample complexity.
Drug-specific Fab therapy in drug overdose. (1987)

The use of digoxin-specific fragments, antigen-binding (Fab) for antidotal therapy of severe digitalis intoxication is rapidly becoming a treatment of choice. Furthermore, studies with this mode of drug-specific therapy using Fab specific for desipramine and for phencyclidine suggest that this treatment may be applicable to a variety of other drugs or drug classes. As Fab technology has advanced, so have laboratory methods for monitoring the efficacy of treatment.
Behaviour of Standard Gravity-fed Administration Sets Used for Intravenous Infusion (1974)

The major factor influencing drip rate during intravenous infusion using a standard administration set is the variation in the venous pressure of the patient. Creep in the plastic material, though present, is shown to be unimportant. For steady and accurate infusion it is necessary to provide the ordinary gravity-fed administration set with some form of servo-control mechanism.
A Recyclable TEMPO Catalyst for the Aerobic Oxidation of Sulfides to Sulfoxides (2010)

The aerobic oxidation of sulfides is accomplished by using a modified version of the TEMPO catalyst (A). The catalyst is active towards a wide range of substrates. In addition, it can be readily recovered by simple filtration and reused without loss of activity.
Hydrostatic Adjustment in Nonhydrostatic, Compressible Mesoscale Models (1997)

The ability of various numerical techniques used in compressible, nonhydrostatic models to handlehydrostatic adjustment is intercompared. The exact solution of a linearized model of an isothermal, compressible, nonrotating atmosphere is compared against those from finite-differenced versions of the samemodel. For the semi-implicit scheme, the scheme traps acoustic waves near the point of excitation but haslittle effect on gravity waves. The time-splitting scheme captures hydrostatic adjustment well.
Supercritical fluids technology for clean biofuel production (2009)

Biofuels are liquid or gaseous fuels that are predominantly produced from biomass for transport sector applications. As biofuels are renewable, sustainable, carbon neutral and environmentally benign, they have been proposed as promising alternative fuels for gasoline and diesel engines. This paper reviews state-of-the-art application of the supercritical fluid (SCF) technique in biofuels production that includes biodiesel from vegetable oils via the transesterification process, bio-hydrogen from the gasification and bio-oil from the liquefaction of biomass, with biodiesel production as the main focus. The global biofuel situation and biofuel economics are also reviewed. The SCF has been shown to be a promising technique for future large-scale biofuel production, especially for biodiesel production from waster oil and fat. Compared with conventional biofuel production methods, the SCF technology possesses a number of advantages that includes fast kinetics, high fuel production rate, ease of continuous operation and elimination of the necessity of catalysts. The harsh operation environment, i.e. the high temperature and high pressure, and its request on the materials and associated cost are the main concerns for its wide application.
Introduction of New Commercial Crops into a Rural Village: A Case of Horticulture Production in Dedaur Village, UP, India (2014)

From the viewpoint of the food chain and based on an intensive survey, we discussed the growth of horticulture and the impact on remote rural villages. A case-study village was selected in Raebareli District, Uttar Pradesh, that is outside the area directly affected by big cities like Lucknow and Kanpur, in order to investigate the real situation of farmers engaged in the newly developed horticulture. According to the survey some farmers can get higher income from the recently introduced commercial crops such as banana, mango and menthol but the cost of cultivation is not small. Therefore, only higher-level farmers can introduce these high-income commercial crops and the lower-level ones cannot. In this sense the direct impact of the newly introduced commercial crops is exclusive to the higher-level farmers. But we focused on the increase in employment opportunities for agricultural laborers within the village. This is created by the commercial crop farming of higher-level farmers. Lower-level villagers cannot self-directively engage in agricultural labor in the horticultural sector, though the higher-level farmers can develop their self-directive farm management. However, in whatever form, expansion of cash income opportunities has brought chances to improve quality of life in remote rural areas where there are very few non-agricultural employment opportunities. It is important for the village to introduce commercial crops as a form of horticultural crop that needs much manpower to cultivate. Such crops carry significance for the village economy, more so than the traditional crops that have been mechanized and need little manpower to cultivate.
Automated X-ray image analysis for cargo security: Critical review and future promise (2016)

We review the relatively immature field of automated image analysis for X-ray cargo imagery. There is increasing demand for automated analysis methods that can assist in the inspection and selection of containers, due to the ever-growing volumes of traded cargo and the increasing concerns that customs- and security-related threats are being smuggled across borders by organised crime and terrorist networks. We split the field into the classical pipeline of image preprocessing and image understanding. Preprocessing includes: image manipulation; quality improvement; Threat Image Projection (TIP); and material discrimination and segmentation. Image understanding includes: Automated Threat Detection (ATD); and Automated Contents Verification (ACV). We identify several gaps in the literature that need to be addressed and propose ideas for future research. Where the current literature is sparse we borrow from the single-view, multi-view, and CT X-ray baggage domains, which have some characteristics in common with X-ray cargo.
Early Lactate-Guided Therapy in Intensive Care Unit Patients: A Multicenter, Open-Label, Randomized Controlled Trial (2010)

In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors. As this was consistent with important secondary endpoints, this study suggests that initial lactate monitoring has clinical benefit. Clinical trial registered with www.clinicaltrials.gov (NCT00270673).
Novel boundary scan circuit and methodology for ECL/BiCMOS VLSI (2002)

The authors introduce a novel technique which combines specially designed ECL (emitter coupled logic) and CMOS circuitry to produce a BiCMOS boundary scan circuit suitable for high-performance BiCMOS and ECL VLSI chips. A circuit description is given, and attention is given to system operation and to observability and controllability aspects. The layout of the BiCMOS scan chain element is shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of Topical Glucocorticoid Treatment on Nasal Mucosal Mast Cells in Allergic Rhinitis (1983)

Glucocorticoids were previously considered not to affect the immediate allergic reaction. However, in a nasal allergen challenge, an inhibitory effect on the nasal symptoms induced at the challenge has been shown to occur in patients treated with a recently developed glucocorticoid, budesonide, for 1 week prior to the challenge. This treatment was also found to reduce tissue histamine levels in the nasal mucosa. Mast cells in the mucosa were therefore studied with a view to finding out whether this reduction could be due to a reduction of mast cells. A double-blind study was performed in 14 asymptomatic patients. Nasal biopsies were made before and after 1 week's treatment with either budesonide or placebo. The number of mast cells was counted in two Epon sections after the specimens had undergone specific staining with toluidine blue. No quantitative or qualitative morphological changes in the mast cells were found as a result of treatment.
Pyroelectric Properties of the B-Polyvilnylidene Fluoride (PVDF) Thin Film Prepared by Vacuum Deposition with Electric Field Application (2002)

Polyvinylidene fluoride (PVDF) thin film having β phase is prepared by vacuum deposition with electric field application and its pyroelectric properties are studied using a dynamic method to examine the possibility of its application to a pyroelectric IR sensor. The pyroelectric responses of the PVDF thin film are characterized as the frequency dispersion in both low and high modulation frequency regions, and their frequency dependences are observed. In the low frequency region (2–100 Hz), the polarization can easily rotate with the increase of modulation frequency and show the maximum since the reorientation rate of domains is higher than the modulation frequency. On the other hand, in the high frequency region (100–1000 Hz), the pyroelectric response decreases as the frequency increases, because the reorientation rate of domains is suppressed and thus, the change of polarization decreases. Pyroelectric coefficient, figure of merits for noise equivalent power and detectivity of the PVDF thin film are measured as 4.39×10-9 C/cm2·K, 7.72×10-10 C·cm/J, and 2.29×10-9 C·cm/J, respectively. Also, the noise equivalent and the detectivity are 1.66×10-7 W/Hz1/2, and 6.03×105 cm·Hz1/2/W, respectively.