gebhart/patrepeval huggingface dataset:
SIRT1 Negatively Regulates the Mammalian Target of Rapamycin (2010)

The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+ dependent deacetylase that is known to regulate caloric restriction mediated longevity in model organisms, and has also been linked to the insulin/IGF signaling pathway. Here we investigated the potential regulation of mTOR signaling by SIRT1 in response to nutrients and cellular stress. We demonstrate that SIRT1 deficiency results in elevated mTOR signaling, which is not abolished by stress conditions. The SIRT1 activator resveratrol reduces, whereas SIRT1 inhibitor nicotinamide enhances mTOR activity in a SIRT1 dependent manner. Furthermore, we demonstrate that SIRT1 interacts with TSC2, a component of the mTOR inhibitory-complex upstream to mTORC1, and regulates mTOR signaling in a TSC2 dependent manner. These results demonstrate that SIRT1 negatively regulates mTOR signaling potentially through the TSC1/2 complex.
FPT155-001: A phase Ia/Ib study of FPT155 (CD80-FC) in patients with advanced solid tumors. (2019)

TPS42 Background: Despite recent advances in immunotherapy, many patients with advanced solid tumors are refractory to available therapies or eventually relapse. Novel immune therapies are needed with differentiated mechanisms of action that result in improved response rates and durability across a broad range of tumors. FPT155 is a first-in-class therapeutic being developed to meet this need. FPT155 is a recombinant fusion protein composed of the extracellular domain of human CD80 fused with the Fc domain of human immunoglobulin G1. It is designed to act as a potent stimulator of anti-tumor immunity through CD28 and thereby co-stimulate T cell responses only in the presence of antigenic T cell receptor (TCR) signaling. FPT155 alone does not induce spontaneous cytokine release by primary human immune cells, in contrast to a CD28 superagonist antibody that exerts TCR stimulus-independent activity. FPT155 also blocks CTLA-4 from competing for endogenous CD80, allowing CD28 signaling to prevail in T cell activation. A murine surrogate of FPT155 is a potent inhibitor of tumor growth that induces complete tumor regression in multiple tumor models, including models that are insensitive to anti-PD1 or anti-CTLA4. Methods: The FPT155-001 study is a Phase 1a/1b open-label, multicenter, dose escalation and expansion study to evaluate the safety and tolerability of FPT155 monotherapy. Phase 1a dose escalation includes an accelerated titration design followed by a standard 3+3 design until the recommended dose for Phase 1b is determined by evaluation of all available safety, pharmacokinetic (PK), and pharmacodynamic (PD) data. Eligible patients with advanced solid tumors who are refractory to all standard therapy for their malignancy will be enrolled in Phase 1a. Phase 1b dose expansion will enroll patients with select tumor types. The primary endpoint is safety in both phases. Key secondary endpoints in Phase 1a include characterization of the FPT155 PK profile and immunogenicity. Key secondary endpoints in Phase 1b include objective response rate, duration of response, progression free survival, and disease control rate. The FPT155-001 trial opened for enrollment in October 2018 and is in progress. Clinical trial information: Submitted - awaiting registration number.
Acoustic Eavesdropping Attacks on Constrained Wireless Device Pairing (2013)

Secure “pairing” of wireless devices based on auxiliary or out-of-band (OOB)-audio, visual, or tactile-communication is a well-established research direction. Specifically, authenticated as well as secret OOB (AS-OOB) channels have been shown to be quite useful for this purpose. Pairing can be achieved by simply transmitting the key or short password over the AS-OOB channel, avoiding potential serious human errors. This paper analyzes the security of AS-OOB pairing. Specifically, we take a closer look at three notable prior AS-OOB pairing proposals and challenge the assumptions upon which the security of these proposals relies, i.e., the secrecy of underlying audio channels. The first proposal (IMD Pairing) uses a low frequency audio channel to pair an implanted RFID tag with an external reader. The second proposal (PIN-Vibra) uses an automated vibrational channel to pair a mobile phone with a personal RFID tag. The third proposal (BEDA) uses vibration (or blinking) on one device and manually synchronized button pressing on another device or simultaneous button pressing on two devices. We demonstrate the feasibility of eavesdropping over acoustic emanations associated with these methods and conclude that they provide a weaker level of security than was originally assumed or desired for the pairing operation.
MobiCent: a Credit-Based Incentive System for Disruption Tolerant Network (2010)

When Disruption Tolerant Network (DTN) is used in commercial environments, incentive mechanism should be employed to encourage cooperation among selfish mobile users. Key challenges in the design of an incentive scheme for DTN are that disconnections among nodes are the norm rather than exception and network topology is time varying. Thus, it is difficult to detect selfish actions that can be launched by mobile users or to pre-determine the routing path to be used. In this paper, we propose MobiCent, a credit-based incentive system for DTN. While MobiCent allows the underlying routing protocol to discover the most efficient paths, it is also incentive compatible. Therefore, using MobiCent, rational nodes will not purposely waste transfer opportunity or cheat by creating non-existing contacts to increase their rewards. MobiCent also provides different payment mechanisms to cater to client that wants to minimize either payment or data delivery delay.
A new synthetic pathway of segmented tri‐block copolyether (1992)

Abstract A new synthetic pathway of A–B–A tri‐block copolyether which is composed of a hydrophilic poly(oxyethylene) unit as an A part and a hydrophobic poly(oxy‐2‐methyl‐trimethylene) unit as a B part is proposed. Telechelic α‐tosyl‐ω‐tosyloxypoly(oxy‐2‐methyl‐trimethylene) derived from tosylation of poly(oxy‐2‐methyl‐trimethylene glycol) (PMTG) was allowed to react with poly(ethylene glycol) (PEG) in the presence of sodium hydroxide. T g of the resulting A–B–A tri‐block copolyether (PEMG) ( M̄ n = 1600) was −72°C and its specific gravity [ D 4 15 ] was 1.055.
<title>Signature-aided tracking using HRR profiles</title> (2001)

This paper describes a methodology for using high-range-resolution ground-moving-target-indicator (HRRGMTI) profiles to aid the association process in an automated tracker. The tracker uses a Kalman filter to estimate the state of targets. These state estimates are used in addition to HRRGMTI measurements to perform data association. The HRRGMTI profiles used to develop and test the system are simulated using the MSTAR dataset of synthetic aperture radar (SAR) imagery. The performance of the system was estimated using a computer simulation that modeled the radars, ground vehicles, and creation of HRRGMTI profiles. Performance relative to a tracker that uses only kinematic information to perform data association is computed and presented.
Secure communications in ATM networks (1995)

High-speed networking technology and standards have progressed dramatically in the past few years and much attention is now focused on deployment efforts, such as the North Carolina Information Highway (NCIH) [7], and applications. With this shift in emphasis, concerns have been raised about information security. Examples of abuse of the Internet abound and unfortunately ATM networks are subject to many of these same abuses. This is of subtanstial concern when thinking about extending the reach of public data networking to broad segments of society.
Synthesis of α-Substituted β-Amino Acids Using Pseudoephedrine as a Chiral Auxiliary (2000)

[reaction: see text] beta-Amino acids are becoming increasingly attractive as intermediates in the synthesis of a variety of molecular structures. However, few methods are available for the synthesis of alpha-substituted beta-amino acids that are both readily scalable and highly stereoselective. Herein we report a new method for synthesizing alpha-substituted beta-amino acids that satisfies both of these requirements using enantiomerically pure pseudoephedrine as a chiral auxiliary.
Guidewire crossing techniques in coronary chronic total occlusion intervention: A to Z (2016)

Percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) poses a management dilemma for the interventional cardiologist. Effective wiring technique is the key to success of PCI in CTO, which requires more patience and skill of the operator. The author herein intends to explore in detail the different wiring strategies such as antegrade approach, dissection and reentry, retrograde and hybrid approach. Hopefully, this review would enhance the understanding of this complex procedure and, consequently, promote safe and effective PCI.
Large scale graph mining for web reputation inference (2015)

The explosion of the number of devices and users on the Internet results in massive amounts of data and information. This poses the most complex challenges in security we have ever faced. The detection of malicious domains and Internet protocol (IP) addresses has been a hot topic in cyber security. We present a scalable and effective graph inference system for detecting malicious domains and IP addresses. The goal is to protect Internet users from network threats. Based on the loopy belief propagation algorithm, the system infers every domain or IP reputation, flagging it with high reputation as malicious one. We have evaluated the system with 75 million-node graph constructed from the huge dataset (500 gigabytes). The system attains performance with 86% and 87% area under receiver operating curves for inferring domain and IP reputations respectively. We demonstrate that the graphical solution provides rapid assessment of safe or risky sites on McAfee's data. It provides an automatic tool for web reputation inference in the field and serves as an assisting tool for “first pass” classification and triaging.
Component-based methodology for hardware design of a dataflow processing network (2005)

This paper proposes a new methodology for the design of reusable IP blocks used in data-flow architectures. These IP blocks are elaborated by encapsulating individual operators that constitute part of an algorithm within wrappers that possess a configurable communication layer. This IPs communicates using the VCI protocol, and the interconnections are automatically generated from a data flow graph. The interface wrapper has been designed and simulated in 0.18 /spl mu/m CMOS technology. When implemented using 2 10-bit input ports, a 12-bit output port and a FIFO depth of 8, synthesis results show that the circuit has a gate count of 1730 NAND gates with a maximum operating frequency of 400 MHz before placement and routing.
Chemometrical analysis of substituent effects on 13C and 15N NMR chemical shifts in 1-aroyl-3-substituted thioureas (1989)

The methods of conjugated deviations and regression analysis have been used to study the substituent effects on 13 C and 15 N NMR chemical shifts of 12 derivatives of 1-aroyl-3-phenylthiourea and 1-aroyl-3-methylthiourea. The 13 C NMR chemical shifts can be described by two latent variables, one univocally correlated with the Hammett substituent constants ( r = 0.993) and the other reflecting the increased shielding of the nuclei due to overlap of the adjacent bond electrons as a consequence of electron-donor or electron-acceptor character of the substituents.This effect is less pronounced with the 15 N nuclei. Application of dual substituent constants σ R , σ F with the additional constant σ α describing the polarization has failed in giving sufficiently close correlations and explanation of the substituent effect found.
The Commonly Used cGMP-dependent Protein Kinase Type I (cGKI) Inhibitor Rp-8-Br-PET-cGMPS Can Activate cGKI in Vitro and in Intact Cells (2008)

Small-molecule modulators of cGMP signaling are of interest to basic and clinical research. The cGMP-dependent protein kinase type I (cGKI) is presumably a major mediator of cGMP effects, and the cGMP analogue Rp-8-Br-PET-cGMPS (Rp-PET) (chemical name: beta-phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphorothioate, Rp-isomer) is currently considered one of the most permeable, selective, and potent cGKI inhibitors available for intact cell studies. Here, we have evaluated the properties of Rp-PET using cGKI-expressing and cGKI-deficient primary vascular smooth muscle cells (VSMCs), purified cGKI isozymes, and an engineered cGMP sensor protein. cGKI activity in intact VSMCs was monitored by cGMP/cGKI-stimulated cell growth and phosphorylation of vasodilator-stimulated phosphoprotein. Unexpectedly, Rp-PET (100 microm) did not efficiently antagonize activation of cGKI by the agonist 8-Br-cGMP (100 microm) in intact VSMCs. Moreover, in the absence of 8-Br-cGMP, Rp-PET (100 microm) stimulated cell growth in a cGKIalpha-dependent manner. Kinase assays with purified cGKI isozymes confirmed the previously reported inhibition of the cGMP-stimulated enzyme by Rp-PET in vitro. However, in the absence of the agonist cGMP, Rp-PET partially activated the cGKIalpha isoform. Experiments with a fluorescence resonance energy transfer-based construct harboring the cGMP binding sites of cGKI suggested that binding of Rp-PET induces a conformational change similar to the agonist cGMP. Together, these findings indicate that Rp-PET is a partial cGKIalpha agonist that under certain conditions stimulates rather than inhibits cGKI activity in vitro and in intact cells. Data obtained with Rp-PET as cGKI inhibitor should be interpreted with caution and not be used as sole evidence to dissect the role of cGKI in signaling processes.
Basic Fibroblast Growth Factor Promotes Neuronal Survival but Not Behavioral Recovery in the Transected and Schwann Cell Implanted Rat Thoracic Spinal Cord (2004)

It was investigated whether the addition of basic fibroblast growth factor (FGF-2) enhances the efficacy of a Schwann cell (SC) bridge to repair the transected spinal cord by assessing tissue sparing and neuronal survival near the graft-cord interfaces, axonal regeneration and myelination in the graft, and behavioral recovery up to 12 weeks post-grafting. Experimental animals received a bridge of SCs within fibrin containing 1 microg of FGF-2; control animals received a SC implant without FGF-2. Sparing of tissue in a 2.5-mm-long segment near the graft-cord borders was 69% in the rostral and 52% in the caudal cord at 6 weeks post-grafting, not significantly different from the control group. With FGF-2, survival of NeuN-positive cells was increased in the rostral cord: 24.4%, 20.4%, and 17.2% of the number of positive cells in the uninjured cord compared to 13.5%, 9.1%, and 8.9% in controls at 3, 6, and 12 weeks post-grafting, respectively. Similarly, in the caudal cord, survival of NeuN-positive cells was increased with FGF-2: 19.3%, 16.8%, and 14.5% compared to 10.8%, 5.6%, and 6.1% in controls. The staining intensity of glial fibrillary acidic protein was significantly higher at the interfaces of both cord stumps at 3 weeks with SC/FGF-2 grafts; chondroitin sulfate proteoglycan (CS-56) staining was more intense in the rostral cord but only at 6 weeks. Blood vessels in the FGF-2 grafts were larger and less regular in shape than those in control grafts. Axonal growth into the bridge was not improved by the addition of FGF-2. Retrogradely traced neurons were not found rostral to the implant, indicating that axons had not grown a few mm into the caudal spinal tissue. Recovery of hind limb function was similar in both groups. Despite the neuroprotective effects of FGF-2, improved effects on axonal regeneration and functional recovery were not observed.
Fenbendazole. II. Biological properties and activity (1977)

Abstract Fenbendazole has a broad spectrum of activity against immature and adult helminths of the intestinal tract and lungs at an oral dose of 5–7.5 mg/kg. This compound has a wide margin of safety in domestic animals without teratogenic side effects. Data are given on metabolism, mode of action and excretion.
Named Entity Extraction using Information Distance (2013)

Named Entity extraction (NEX) problem consists of automatically constructing a gazette containing instances for each NE of interest. NEX is important for domains which lack a corpus with tagged NEs. In this paper, we propose a new unsupervised (bootstrapping) NEX technique, based on a new variant of the Multiword Expression Distance (MED) (Bu et al., 2010) and information distance (Bennett et al., 1998). Ecacy of our method is shown using comparison with BASILISK and PMI in agriculture domain. Our method discovered 8 new diseases which are not found in Wikipedia.
Lazy-Adaptive Tree (2009)

Flash memories are in ubiquitous use for storage on sensor nodes, mobile devices, and enterprise servers. However, they present significant challenges in designing tree indexes due to their fundamentally different read and write characteristics in comparison to magnetic disks. In this paper, we present the Lazy-Adaptive Tree (LA-Tree), a novel index structure that is designed to improve performance by minimizing accesses to flash. The LA-tree has three key features: 1) it amortizes the cost of node reads and writes by performing update operations in a lazy manner using cascaded buffers, 2) it dynamically adapts buffer sizes to workload using an online algorithm, which we prove to be optimal under the cost model for raw NAND flashes, and 3) it optimizes index parameters, memory management, and storage reclamation to address flash constraints. Our performance results on raw NAND flashes show that the LA-Tree achieves 2x to 12x gains over the best of alternate schemes across a range of workloads and memory constraints. Initial results on SSDs are also promising, with 3x to 6x gains in most cases.
Genetic Basis for Clinical Response to CTLA-4 Blockade (2015)

To the Editor: Snyder et al. (Dec.4 issue) 1 state that in patients with melanoma who clinically benefit from blockade of cytotoxic T-lymphocyte antigen 4 (CTLA-4), the tetrapeptide sequences in tumor neoantigens were identical to those in known antigenic peptides in pathogens.The authors probably correctly interpret that this coincidence reflects cross-reactivity between cancer neoepitopes and relevant epitopes from the microbial counterparts.However, another explanation is possible.It could be that there was a positive selection in the thymus for rearranged T-cell receptors (TCRs) that preferentially recognize pathogen-encoded and major histocompatibility complex (MHC)-presented antigenic epitopes.Such a feature could have been sculpted by evolution in TCR variable genes and HLA genes.More information about these interpretations could be gained by knowing the serologic status of the patients with respect to the putatively cross-reacting microbes.For instance, it would be very interesting to ascertain whether the serum samples from patient CR9306 were positive for anti-hepatitis D virus antibodies.Negative serologic status does not completely exclude previous subclinical contact with the infectious agent but would certainly argue against crossreactivity as an explanation for these observations.
Světový program opatření pro mládež do roku 2000 a dále (2018)

N/A
Lysophosphatidylcholine increases endothelial permeability: role of PKCα and RhoA cross talk (2005)

Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid that can be generated by pathological activities. We investigated the hypothesis that LPC signals increase in endothelial permeability. Stimulation of human dermal microvascular endothelial cells and bovine pulmonary microvascular endothelial cells with LPC (10-50 microM) induced decreases (within minutes) in transendothelial electrical resistance and increase of endothelial permeability. LPC activated (within 5 min) membrane-associated PKC phosphotransferase activity in the absence of translocation. Affinity-binding analysis indicated that LPC induced increases (also by 5 min) of GTP-bound RhoA, but not Rac1 or Cdc42. By 60 min, both signaling pathways decreased toward baseline. Inhibition of RhoA with C3 transferase inhibited approximately 50% of LPC-induced resistance decrease. Pretreatment with PKC inhibitor Gö-6983 (concentrations selective for classic PKC), PMA-induced depletion of PKCalpha, and transfection of antisense PKCalpha oligonucleotide each prevented 40-50% of the LPC-induced resistance decrease. Furthermore, these three PKC inhibition strategies inhibited 60-80% of the LPC-induced GTP-bound RhoA. These results show that LPC directly impairs the endothelial barrier function that was dependent, at least in part, on cross talk of PKCalpha and RhoA signals. The evidence indicates that elevated LPC levels can contribute to the activation of a proinflammatory endothelial phenotype.
Lead-Free Relaxor-Like 0.75Bi<sub>0.5</sub>K<sub>0.5</sub>TiO<sub>3</sub>– 0.25BiFeO<sub>3</sub>Ceramics with Large Electric Field-Induced Strain (2012)

Dense and phase-pure ferroelectric ceramics of 75 mol.% Bi0.5K0.5TiO3 – 25 mol.% BiFeO3 are prepared by the conventional solid state reaction method. Their crystal structure is analyzed and discussed. The dielectric and piezoelectric properties of the ceramics are investigated at various temperatures. The ceramics exhibit relaxor-like dielectric properties and high electric field-induced strain (equivalent to 250-300 pm/V at 25-75°C), not previously reported for this composition, making it a promising lead-free alternative for actuator applications.
Cyber-Physical-Social Systems: Taxonomy, Challenges, and Opportunities (2022)

A Cyber-Physical-Social System (CPSS) is a novel paradigm of cyber-physical and cyber-social systems with a highly inhomogeneous and distributed nature integrating dynamic stochastic hybrid systems including computation, communication, sensing and actuation, and social systems.Their usage can be traced to homes such as smart homes, manufacturers in Industry 5.0, critical infrastructures, smart cities, medicines, healthcare systems, and many other examples. They can simplify and speed up tasks and provide a higher level of control and accessibility. In this study, we provide a systematic review of the definition of CPSS,and an uniform definition of CPSS. We propose a novel taxonomy to define CPSS to help future researches and system designing. The CPSS taxonomy aims to provide a comprehensive and understating of CPSS characteristics and aspects from system-to-system point of view. Furthermore, we discuss about social integration in CPSS and their relationships with CPS. We mention issues and opportunities in CPSS in the designing and implementing phases.
Self-calibration of a scanning white light interference microscope (2000)

This paper presents a self-calibration technique for calibrating a high-resolution scanning white light interference microscope in the Z-direction. The calibration result, which consists of the mean sensitivity and the linearity error, can be obtained from two sets of profile measurement data before and after a small shift ?z of the sample in the Z-direction. To assure the accuracy of the calibration, a method of measuring and controlling ?z, in which a laser interferometer is used as a reference, is proposed. Using the proposed method ?z, as well as the calibration result, can be ensured to an accuracy that is determined by the stability of the interferometer and that of the calibration target. A calibration setup consisting of a PZT for generating ?z and a built-in compact interferometer for monitoring ?z is constructed. In addition, calibration experiments are performed after investigating the basic performance of the built-in interferometer. The effectiveness of the proposed self-calibration method is confirmed from the experimental results.