gebhart/patrepeval huggingface dataset:
KTS and RTS-Disintegrins: Anti-Angiogenic Viper Venom Peptides Specifically Targeting the &#945;1&#946; 1 Integrin (2007)

Integrins alpha(1)beta(1) and alpha(2)beta(1) are highly expressed on the microvascular endothelial cells, and blocking of their adhesive properties significantly reduced the VEGF-driven neovascularization ratio and tumor growth in animal models. Hence, inhibitors of the alpha(1)beta(1) and alpha(2) beta(1) integrins, alone or in combination with antagonists of other integrins involved in angiogenesis (eg. alpha (v)beta(3), alpha(v)beta(5), and alpha(6)beta(4)), may prove beneficial in the control of tumor neovascularization. Viperidae snakes have developed in their venoms an efficient arsenal of integrin receptor antagonists. KTS-(obtustatin, viperistatin, lebestatin) and RTS- (jerdostatin) disintegrins represent viper venom peptides that specifically block the interaction of the alpha(1)beta (1) integrin with collagens IV and I in vitro and angiogenesis in vivo. The possible therapeutic approach towards tumor neovascularization by targeting the alpha (5)beta (1), alpha(v)beta(5) and alpha (v)beta(3) integrins with RGD-bearing disintegrins has been explored in a number of laboratories. Here we discuss structure-function correlations of the novel group of specific (K/R)TS-disintegrins targeting the alpha(1)beta(1) integrin.
Making Connections: Linkages Through Disability Blogging (2007)

No abstract available
Reducing imaging defects in high-resolution photolithography (2008)

Photoresist defects can occur in large, seemingly noncritical features in high-resolution photolithography although it is capable of resolving features of much smaller dimensions. Both optical illumination and wafer topography may contribute to the formation of resist defects in large features. This letter examines optical simulations to uncover the specific nature of these resist defects and proposes local correction methods to improve the photolithographic process. For example, adding a back-etched phase feature in the center of a large isolated trench feature reduces the illumination-responsible resist scumming effect, and optimizing the multilayered film stack can eliminate the resist defect when printing a large contact feature on the structured wafer substrate.
Lightweight Authentication for Secure Automotive Networks (2015)

We propose a framework to bridge the gap between secure authentication in automotive networks and on the internet. Our proposed framework allows runtime key exchanges with minimal overhead for resource-constrained in-vehicle networks. It combines symmetric and asymmetric cryptography to establish secure communication and enable secure updates of keys and software throughout the lifetime of the vehicle. For this purpose, we tailor authentication protocols for devices and authorization protocols for streams to the automotive domain. As a result, our framework natively supports multicast and broadcast communication. We show that our lightweight framework is able to initiate secure message streams fast enough to meet the real-time requirements of automotive networks.
A security monitoring service for NoCs (2008)

As computing and communications increasingly pervade our lives, security and protection of sensitive data and systems are emerging as extremely important issues. Networks-on-Chip (NoCs) have appeared as design strategy to cope with the rapid increase in complexity of Multiprocessor Systems-on-Chip (MPSoCs), but only recently research community have addressed security on NoC-based architectures.
Hyaluronan-decorated polymer nanoparticles targeting the CD44 receptor for the combined photo/chemo-therapy of cancer (2015)

In the attempt to develop novel concepts in designing targeted nanoparticles for combination therapy of cancer, we propose here CD44-targeted hyaluronan-decorated double-coated nanoparticles (dcNPs) delivering the lipophilic chemotherapeutic docetaxel (DTX) and an anionic porphyrin (TPPS₄). dcNPs are based on electrostatic interactions between a negative DTX-loaded nanoscaffold of poly(lactide-co-glycolide), a polycationic shell of polyethyleneimine entangling negatively-charged TPPS₄ and finally decorated with hyaluronan (HA) to promote internalization through CD44 receptor-mediated endocytosis. DTX/TPPS₄-dcNPs, prepared through layer-by-layer deposition, showed a hydrodynamic diameter of around 180 nm, negative zeta potential and efficient loading of both DTX and TPPS₄. DTX/TPPS₄-dcNPs were freeze-dried with trehalose giving a powder that could be easily dispersed in different media. Excellent stability of dcNPs in specific salt- and protein-containing media was found. Spectroscopic behavior of DTX/TPPS₄-dcNPs demonstrated a face-to-face arrangement of the TPPS₄ units in non-photoresponsive H-type aggregates accounting for an extensive aggregation of the porphyrin embedded in the shell. Experiments in MDA-MB-231 cells overexpressing the CD44 receptor demonstrated a 9.4-fold increase in the intracellular level of TPPS₄ delivered from dcNPs as compared to free TPPS₄. Light-induced death increased tremendously in cells that had been treated with a combination of TPPS₄ and DTX delivered through dcNPs as compared with free drugs, presumably due to efficient uptake and co-localization inside the cells. In perspective, the strategy proposed here to target synergistic drug combinations through HA-decorated nanoparticles seems very attractive to improve the specificity and efficacy of cancer treatment.
Use of Inhibitors for Scale Control in Brine-Producing Gas and Oil Wells (1990)

Summary Field and laboratory work sponsored by the Gas Research Inst. (GRI) and the U.S. DOE showed that calcium carbonate (CaCOз) scale formation in waters produced with natural gas and oil can be prevented by injection of phosphonate inhibitor into the formation, even if the formation is sandstone without calcite binding material. Inhibitor squeeze jobs were carried out on the DOE's geopressured/geothermal Gladys McCall brine/gas well and GRI's coproduction wells in the Hitchcock field. After the inhibitor squeeze on Gladys McCall, the well produced more than 5 million bbl [800× 103 m3] water at a rate of about 30, 000 B/D [4770 m3/d] without CaCOз scaling. Before the inhibitor squeeze, the well could not be produced above 15, 000 B/D [2385 m3/d] without significant scale formation. In the GRI brine/gas coproduction field tests, inhibitor squeezes have been successfully used to prevent scaling. Laboratory work has been conducted to determine what types of oilfield waters are subject to scaling. This research has led to the development of a saturation index and accompanying nomographs that allow prediction of when scale will develop into a problem in brine production. Core samples from both fields were used in laboratory studies. Analytical methods to analyze inhibitors in brine at low levels were extended. A complete history of field development and the laboratory backup experiments is included in this paper.
Enhancing Utilization of SIMD-Like Accelerator for Sparse Convolutional Neural Networks (2019)

Although the existing single-instruction-multiple-data-like (SIMD) accelerators can handle the compressed format of sparse convolutional neural networks, the sparse and irregular distributions of nonzero elements cause low utilization of multipliers in a processing engine (PE) and imbalanced computation between PEs. This brief addresses the above issues by proposing a data screening and task mapping (DSTM) accelerator which integrates a series of techniques, including software refinement and hardware modules. An efficient indexing module is introduced to identify the effectual computation pairs and skip unnecessary computation in a line-grained manner. The intra-PE load imbalance is alleviated with weight data rearrangement. An effective task sharing mechanism further balances the computation between PEs. When compared with the state-of-the-art SIMD-like accelerator, the proposed DSTM enhances the average PE utilization by 3.5×. The overall processing throughput is 59.7% higher than the previous design.
Identifying clinically important difference on the Epworth Sleepiness Scale: results from a narcolepsy clinical trial of JZP-110 (2017)

A ≥25% reduction in patients' subjective ESS score may be useful as a threshold to identify patients with narcolepsy who respond to JZP-110 treatment.
Immune Cell Population in Ovarian Tumor Microenvironment (2017)

Ovarian cancer, the third most common with highest mortality rates gynecological malignancy among women in China, is characterized by a unique tumor immune microenvironment. Immune-cell population infiltrated into the tumor tissue among patients with ovarian cancer are associated positively or negatively with antitumor activity. The imbalance between immune activation and immune suppression can result in oncogenesis and cancer progression. Therefore, intense investigation of the immunologic mechanism of ovarian cancer is urgently needed, and a comprehensive understanding of the network in which immune cells interact with the microenvironment, tumor cells and each other will greatly promote the development of more effective immunotherapies for ovarian cancer. In this review, we will focus on the main immune-cell population in ovarian tumor microenvironment, discuss their role in tumor progression and try to give the readers a new perspective in finding more promising therapeutic targets for cancers.
Treatment of brain disease in the mucopolysaccharidoses (2017)

The mucopolysaccharidosis (MPS) disorders are a group of lysosomal storage diseases caused by lysosomal enzyme deficits that lead to glycosaminoglycan accumulation, affecting various tissues throughout the body based on the specific enzyme deficiency. These disorders are characterized by their progressive nature and a variety of somatic manifestations and neurological symptoms. There are established treatments for some MPS disorders, but these mostly alleviate somatic and non-neurological symptoms and do not cure the disease. Patients with MPS I, II, III, and VII can present with neurological manifestations such as neurocognitive decline and behavioral problems. Treatment of these neurological manifestations remains challenging due to the blood-brain barrier (BBB) that limits delivery of therapeutic agents to the central nervous system (CNS). New therapies that circumvent this barrier and target brain disease in MPS are currently under development. They primarily focus on facilitating penetration of drugs through the BBB, delivery of recombinant enzyme to the brain by gene therapy, or direct CNS administration. This review summarizes existing and potential future treatment approaches that target brain disease in MPS. The information in this review is based on current literature and presentations and discussions during a closed meeting by an international group of experts with extensive experience in managing and treating MPS.
Role of photonic bandgaps in polarization-independent grating waveguide structures (2008)

Polarization independence in a one-dimensional resonant grating waveguide structure involves the simultaneous excitation of two guided modes propagating in different directions. Possible simultaneous excitations occur when the two excited guided modes have either the same polarization, i.e., TE-TE (transverse electric) or TM-TM (transverse magnetic), or different polarizations, i.e., TE-TM. Simultaneous excitations may result in bandgaps and singularities. We confirm and show that in order to achieve polarization independence, it is necessary to find the conditions that minimize the effects of such bandgaps and singularities and experimentally demonstrate tunable polarization independence for simultaneously excited TE-TM-guided modes.
The electromigration failure distribution: The fine-line case (1991)

The electromigration failure distribution for fine-line interconnects is unknown, but expected to be strongly affected by microstructure. Results from tests on lines with controlled grain sizes and distributions of grain sizes argue for a series model of failure elements in fine lines. A new statistical model of electromigration is developed based on an extension of the failure model of Shatzkes and Lloyd [J. Appl. Phys. 59 (1986)] incorporating the statistics of microstructure and concomittant variations in the activation energy for grain-boundary diffusion. The resulting electromigration failure distribution is well-approximated by a multilognormal distribution in the fine-line case. This approach results in a failure distribution calculated from first principles which, unlike the lognormal distribution, is scalable.
Activation Mechanism of Anticoagulant Protein C in Large Blood Vessels Involving the Endothelial Cell Protein C Receptor (1998)

Protein C is an important regulatory mechanism of blood coagulation. Protein C functions as an anticoagulant when converted to the active serine protease form on the endothelial cell surface. Thrombomodulin (TM), an endothelial cell surface receptor specific for thrombin, has been identified as an essential component for protein C activation. Although protein C can be activated directly by the thrombin-TM complex, the conversion is known as a relatively low-affinity reaction. Therefore, protein C activation has been believed to occur only in microcirculation. On the other hand, we have identified and cloned a novel endothelial cell surface receptor (EPCR) that is capable of high-affinity binding of protein C and activated protein C. In this study, we demonstrate the constitutive, endothelial cell-specific expression of EPCR in vivo. Abundant expression was particularly detected in the aorta and large arteries. In vitro cultured, arterial endothelial cells were also found to express abundant EPCR and were capable of promoting significant levels of protein C activation. EPCR was found to greatly accelerate protein C activation by examining functional activity in transfected cell lines expressing EPCR and/or TM. EPCR decreased the dissociation constant and increased the maximum velocity for protein C activation mediated by the thrombin-TM complex. By these mechanisms, EPCR appears to enable significant levels of protein C activation in large vessels. These results suggest that the protein C anticoagulation pathway is important for the regulation of blood coagulation not only in microvessels but also in large vessels.
Mass-spectrometry assisted heavy-atom derivative screening of human FcγRIII crystals (2000)

A heavy-atom screening method aided by mass spectrometry is described here. Using mass spectrometry, several heavy-atom compounds have been screened in order to obtain potential phasing derivatives for the crystals of a human immunoglobulin Fc receptor, Fc gamma RIII. Of these, HgCl(2), trimethyllead acetate (TMLA), KAu(CN)(2), K(2)PtCl(4) and PbAc(2) reacted with Fc gamma RIII in solution, whereas KAuCl(4), ethylmercuric thiosalicylate (EMTS) and Na(2)WO(4) did not. To validate the mass-spectrometry results, these heavy-atom compounds were also used to soak crystals of Fc gamma RIII and crystallographic data were collected after soaking. The calculated R(iso) indicated that HgCl(2), TMLA, K(2)PtCl(4) and PbAc(2) were likely to form derivatives, whereas KAu(CN)(2) and Na(2)WO(4) were not. The anomalous difference Patterson maps calculated for the HgCl(2) and TMLA derivative data sets were of good quality and can readily be interpreted by hand. In general, the number of binding sites obtained from the crystallographic phase refinement of the derivatives agrees with those obtained from the mass spectrometry, suggesting that mass spectrometry can be applied for rapid searching of suitable heavy-atom derivatives for X-ray crystallography.
Living Isospecific Styrene Polymerization by Chiral Benzyl Titanium Complexes That Contain a Tetradentate [OSSO]-Type Bis(phenolato) Ligand (2006)

Dibenzyl complexes [Ti(OC6H2-R1-6-R2-4)2{S(CH2)2S}(CH2Ph)2] (2a−c; R1 = tBu, R2 = Me, a; R1, R2 = tBu, b; R1 = H, R2 = Me, c) with a tetradentate dianionic [OSSO]-type ligand were synthesized from the corresponding titanium dichloro complexes [Ti(OC6H2-R1-6-R2-4)2{S(CH2)2S}Cl2] and benzylmagnesium chloride in toluene. NMR spectroscopic monitoring of the reaction of the dibenzyl complex 2b with B(C6F5)3 in bromobenzene indicates the formation of a thermally sensitive benzyl cation [Ti(OC6H2-tBu2-4,6)2{S(CH2)2S}(CH2Ph)]+. 1H NMR spectra at −30 °C show two C1-symmetric diastereomers in a 55:45 ratio, suggesting slow epimerization on the NMR time scale at this temperature. The benzyl complex 2c, which does not bear bulky ortho-substituents, was found to be fluxional and unstable in solution. Related benzyl complexes of the 1,5-dithiapentanediyl-linked ligand [Ti(OC6H2-tBu-6-R-4)2{S(CH2)3S}(CH2Ph)2] (4a,b; R = Me, a; R = tBu, b) were synthesized in an analogous manner and were also shown to be highly fluxional and unstable in solution, decomposing immediately upon addition of B(C6F5)3. Using the 1,4-dithiabutanediyl-linked dibenzyl complexes and the activators [PhNMe2H][B(C6F5)4]/AlnOct3, the living isospecific polymerization of styrene could be achieved for the first time. The resulting isotactic polystyrenes show narrow molecular weight distributions (Mw/Mn < ∼1.2). A linear relation between the number-averaged molecular weights Mn and the monomer conversion was observed.
New Virtual Sub-Carrier Allocation Method for CI Multiplexed Channel Estimation Signals on MIMO-OFDMA (2007)

In a MIMO-OFDMA system, carrier interferometry multiplexed (CIM) signals with the discrete Fourier transform based channel estimation (CIM/DFT-CE) have been proposed. Using CIM/DFT-CE, high channel estimation accuracy is realized with a small number of symbols under ideal conditions. In this paper we indicate that the channel estimation accuracy of the sub-channel at the edge in the active band is significantly degraded under real conditions. To improve this degradation, we propose a new virtual sub-carrier allocation method, taking the periodic property of the CIM signals in the receiver into consideration. We use computer simulation to demonstrate that the channel estimation accuracy of the sub-channel at the edge is improved by the proposed method under real conditions.
DHEA-S production capacity in relation to perceived prolonged stress (2022)

We and other research groups have previously described that levels of the anabolic hormone dehydroepiandrosterone sulfate (DHEA-S) are lowered in individuals who report prolonged stress. We have also shown that the DHEA-S production capacity during acute stress is attenuated in individuals reporting high prolonged stress. This study aimed to further investigate the DHEA and DHEA-S production capacity in relation to prolonged stress. Eighty-one healthy participants in the age 20-50 years old were included in the study and divided into a low stress (<i>n</i> = 45) and a high stress group (<i>n</i> = 36) according their response to a single question regarding perceived stress during the preceding month. They underwent the Trier Social Stress Test while blood samples were drawn before, during and after the stress test. The concentration of DHEA, DHEA-S, cortisol and ACTH was measured. The results showed that the high stress group exhibited a significantly lower response of DHEA-S (40% lower) than the low stress group, while DHEA, cortisol and ACTH responses did not differ between the groups. Reduced DHEA-S production may constitute one of the links between stress and poor health.
Stathmin involvement in the maternal embryonic leucine zipper kinase pathway in glioblastoma (2016)

The results presented herein point stahtmin as a downstream target in the MELK pathway that plays a role in malignant progression of astrocytomas.
Image Semantic Analysis and Application Based on Knowledge Graph (2018)

The semantic analysis technology of image has always been a difficult point in image field. As an intelligent and efficient way of organizing, knowledge graph can help users accurately query the information. This paper firstly puts forward an image semantic analysis process based on knowledge graph, then adopts deep learning model to describe image's features. Image semantic knowledge fusion and processing are studied on this basis. A multilevel image semantic model is constructed to manage entity triples and support automatic construction. Finally, applications for semantic retrieval and visualization are analyzed which has some guiding significance for information organization and knowledge management of media semantic.
Classification of summarized videos using hidden markov models on compressed chromaticity signatures (2001)

Tools for efficiently summarizing and classifying video sequences are indispensable to assist in the synthesis and analysis of digital video. In this paper, we present a method for effective classification of different types of videos that uses the output of a concise video summarization technique that forms a list of keyframes. The summarization is produced by a method recently presented, in which we generate a universal basis on which to project a video frame feature that effectively reduces any video to the same lighting conditions. Each frame is represented by a compressed chromaticity signature. A multi-stage hierarchical clustering method efficiently summarizes any video. Here, we classify TV programs using a trained hidden Markov model, using the keyframe plus temporal features generated in the summaries.
A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox. (1994)

The superoxide-forming NADPH oxidase of human phagocytes is composed of membrane-bound and cytosolic proteins which, upon cell activation, assemble on the plasma membrane to form the active enzyme. Patients suffering from chronic granulomatous disease (CGD) are defective in one ofthe following components: p47-phox and p67-phox, residing in the cytosol of resting phagocytes, and gp9l-phox and p22-phox, constituting the membrane-bound cytochrome b55s. In an X-linked CGD patient we identified a novel missense mutation predicting an Asp --Gly substitution at residue 500 of gp9l-phox, associated with normal amounts of nonfunctional cytochrome b559 in the patient's neutrophils. In PMA-stimulated neutro- phils and in a cell-free translocation assay with neutrophil membranes and cytosol, the association of the cytosolic proteins p47-phox and p67-phox with the membrane fraction of the patient was strongly disturbed. Furthermore, a synthetic peptide mimicking domain 491-504 of gp9l-phox inhibited NADPH oxidase activity in the cell-free assay (IC5o about 10 ,uM), and the translocation of p47-phox and p67-phox in the cell-free translocation assay. We conclude that residue 500 of gp9l-phox resides in a region critical for stable binding of p47phox and p67-phox. (