gebhart/patrepeval huggingface dataset:
Evaluation of an Automated Digital Scoring System of Dental Plaque. (2020)

<b>Purpose:</b> Measurement of dental plaque is frequently used as an indicator of overall oral health. The purpose of this study was to compare a manual (visual) plaque scoring system (University of Mississippi Oral Hygiene Index, UM-OHI) with an innovative automated digital scoring system.<b>Methods:</b> Mechanically ventilated, intensive care unit (ICU) patients (n=79) were the study population. Informed consent was given by the subject's legally authorized representative. Digital images of dental plaque were taken using an intraoral camera; and the quantity of dental plaque was scored using the UM-OHI and with a digitized automated scoring system. Distributions of dental plaque scores from both methods were plotted. Pearson correlation coefficients and intra-class coefficients were calculated between the two methods.<b>Results:</b> Participant mean age was 57.3 years; respiratory failure was the most prevalent admission diagnosis (55.7%). The mean percentage of dental plaque calculated by the manual method was found to be remarkably higher (67.3% ± 18.7%) than the percentage of dental plaque calculated by the automated scoring method (23.7% ± 15.2%) (<i>p</i><0.0001). Despite remarkably different distributions of plaque scores, both the automated and manual scoring systems demostrated relatively high correlation (<i>r</i>=0.62) and good reliability (ICC=0.63).<b>Conclusion:</b> The automated digital scoring system resulted in a significantly lower overall percentage of total dental plaque as compared to the UM-OHI manual scoring system. While the automated digital scoring system may be more precise than a manual (visual) scoring system, its use should be weighed against the added effort, cost, and expertise required for the method. Further study is needed to determine whether an automated digital scoring system can be commercialized and is warranted for use outside of research settings.
Optical Orthogonal Frequency Division Multiple Access (OFDMA)-based Optical Access/Metro Ring Networks (2008)

A novel unidirectional path switched ring (UPSR) based on optical orthogonal frequency division multiple access (OFDMA) technologies is introduced. Two types of reservation-based and token-based multiple access control (MAC) protocols are proposed and compared.
Load balancing for structured P2P networks using the advanced finger selection algorithm (AFSA) (2010)

Structured Peer-to-Peer (P2P) networks, such as networks based on Distributed Hash Tables (DHTs), can be enhanced by using load balancing mechanisms. Current load balancing mechanisms are either trying to achieve even distribution of objects among nodes, make the address space as evenly populated as possible, or both. However, we have taken a different approach to load balancing in this paper and we have defined the Advanced Finger Selection Algorithm (AFSA) which is not focused on balancing the objects among the nodes and does not require evenly populated address space. AFSA is an algorithm which changes the way how nodes are selected as fingers to the overlay routing tables in structured P2P networks. We implemented the AFSA algorithm for both Chord and Bamboo and we evaluated it with simulations.
DeepTrans - Extending the Model-based Approach to Functional Verification of Address Translation Mechanisms (2006)

This paper presents a new test case generation technology, specifically targeted at verifying systems that include address translation mechanisms. The ever-growing demand for performance makes these mechanisms more complex, thereby increasing the risk of bugs and increasing the need for such technology. DeepTrans is a package that extends existing test generators with address translation testing capabilities. It uses a declarative modeling language that includes constructs for describing the address translation process, commonly used translation resources, and architecture rules related to translation. The address translation model is converted to a constraint satisfaction problem that is solved simultaneously with the problem formulated by the generator. DeepTrans is currently used by two different IBM test generators
Discovery of 8-Amino-imidazo[1,5-<i>a</i>]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis (2015)

Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition and for the treatment of B cell related diseases. We report a series of compounds based on 8-amino-imidazo[1,5-a]pyrazine that are potent reversible BTK inhibitors with excellent kinase selectivity. Selectivity is achieved through specific interactions of the ligand with the kinase hinge and driven by aminopyridine hydrogen bondings with Ser538 and Asp539, and by hydrophobic interaction of trifluoropyridine in the back pocket. These interactions are evident in the X-ray crystal structure of the lead compounds 1 and 3 in the complex with the BTK enzyme. Our lead compounds show desirable PK profiles and efficacy in the preclinical rat collagen induced arthritis model.
IL-17D mediated cancer rejection (162.26) (2012)

Abstract Immune system interaction with cancers can either enhance or prevent tumor formation. Cytokine secretion by immune infiltrates and tumor cells are important in regulating this process. IL-17A, a pro-inflammatory member of the IL-17 family, has been shown to have conflicting results in regards to cancer progression or regression. Other members of the IL-17 family, such as IL-17D, have no known roles in immune responses to cancer, or endogenous function. Our lab possesses matched methylcholanthrene (MCA)-induced tumor cell lines that will continuously grow (Progressors) or reject (Regressors) after transplantation into syngeneic WT mice. The regresssor cell lines can grow in immune-deficient RAG2-/- mice, indicating that their rejection in WT mice requires an intact immune system. Our lab has used these cell lines to identify differential cytokine expression profiles from microarray analysis. We have obtained data that shows IL-17D transcript and protein are significantly overexpressed in regressor cell lines when compared to progressor cell lines. Overexpression of IL-7D in progressor tumor cell lines leads to their rejection in WT mice in a NK cell dependent manner. We hypothesize that IL-17D expression in regressor cell lines leads to immune-mediated tumor rejection by recruiting NK cells that polarize M1 macrophages in the tumor microenvironment.
Expression Profiling of Prostate Cancer Progression (2007)

DNA microarray technology has revolutionized cancer research through the ability to obtain a genomewide perspective of gene expression. More than 25 published studies have profiled human prostate tissues, and the number of dysregulated genes identified through microarray studies is still expanding. However, although we have gained tremendous insight into expression differences between benign and cancerous prostate tissue, much remains to be understood regarding gene expression in the context of progression from benign to clinically localized prostate cancer to metastatic disease. In this review, after briefly introducing DNA microarrays and the current state of expression profiling in prostate cancer (CaP), we focus on how profiling studies have contributed to our knowledge of gene expression in CaP progression, particularly in advanced disease. Studies attempting to identify expression signatures correlating with Gleason grade are discussed. In addition, studies characterizing expression in aggressive tumors, either by profiling metastatic samples directly or identifying gene signatures characteristic of localized tumors likely to recur after surgical resection, are analyzed. Results from these studies will be synthesized to characterize CaP progression and identify focused areas of future analysis. The limitations of current approaches are also addressed, particularly in translating conclusions from these studies to clinical practice. We conclude with a discussion of important advances and future areas for expression profiling in the context of understanding CaP progression.
Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets (2009)

Xenotransplantation of porcine islets into diabetic non-human primates is characterized by (i) an initial massive graft loss possibly due to the instant blood-mediated inflammatory reaction and (ii) the requirement of intensive, clinically unfriendly immunosuppressive therapy. We investigated whether the transgenic expression of a human complement-regulatory protein (hCD46) on porcine islets would improve the outcome of islet xenotransplantation in streptozotocin-induced diabetic Cynomolgus monkeys. Immunosuppression consisted of thymoglobulin, anti-CD154 mAb for costimulation blockade, and mycophenolate mofetil. Following the transplantation of islets from wild-type pigs (n = 2) or from 1,3-galactosyltransferase gene-knockout pigs (n = 2), islets survived for a maximum of only 46 days, as evidenced by return to hyperglycemia and the need for exogenous insulin therapy. The transplantation of islets from hCD46 pigs resulted in graft survival and insulin-independent normoglycemia in four of five monkeys for the 3 months follow-up of the experiment. One normalized recipient, selected at random, was followed for >12 months. Inhibition of complement activation by the expression of hCD46 on the pig islets did not substantially reduce the initial loss of islet mass, rather was effective in limiting antibody-mediated rejection. This resulted in a reduced need for immunosuppression to preserve a sufficient islet mass to maintain normoglycemia long-term.
Cerebrospinal Fluid Secretory Ca2+-Dependent Phospholipase A2 Activity Is Increased in Alzheimer Disease (2009)

Adult human CSF has sPLA2 activity that can be measured reliably with the assay described. This enzyme activity in the CSF is independent of both sex and age and might serve as a valuable biomarker of neuroinflammation, as we demonstrated in Alzheimer disease.
Sound wave control device (1990)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Kazuyoshi Iida, Keichiro Mizuno, Kazuo Kondo; Sound wave control device. J. Acoust. Soc. Am. 1 April 1990; 87 (4): 1835. https://doi.org/10.1121/1.399347 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
COHERENT THZ ELECTROMAGNETIC RADIATION EMISSION AS A SHOCK WAVE DIAGNOSTIC AND PROBE OF ULTRAFAST PHASE TRANSFORMATIONS (2009)

We present the first experimental observations of terahertz frequency radiation emitted when a terahertz frequency acoustic wave propagates past an interface between materials of differing piezoelectric coefficients. We show that this fundamentally new phenomenon can be used to probe structural properties of thin films. Then, we present molecular dynamics simulations showing that detectable THz frequency radiation can be emitted when a wurtzite structure crystal transforms to a rocksalt structure under shock compression on picosecond timescales. We show that information about the kinetics of the transformation is contained in the time‐dependence of the THz field.
Gain on the green (504 nm) excimer band of I2 (1983)

Gain on the green excimer band (λ∼504 nm) of the iodine dimer has been observed in electron-beam-pumped mixtures of Ar (or Ne), and hydrogen iodide. A peak gain coefficient of γ&gt;1.1% cm−1 is measured at 506 nm with a tunable dye laser and the full width at half-maximum (FWHM) of the gain spectrum in Ar diluent is 13 nm. Temporally resolved gain and fluorescence measurements show that the green emission originates from an I2 ion pair state other than D′. However, strong collisional coupling between the upper states of the UV (λ=342 nm) and green bands and superfluorescence on the UV band (I342∼2 MW cm−2) appear to limit the green gain coefficient to &lt;20% of its small-signal value. Consequently, suppression of superfluorescence on the UV D′→A′ bands of the homonuclear halogens should lead to a new family of excimer lasers with wavelengths extending from the green into the ultraviolet.
Isolation and Characterization of a New Polysaccharide-producing<i>Acetobacter</i>sp. (1984)

Journal Article Isolation and Characterization of a New Polysaccharide-producing Acetobacter sp. Get access Hiroyuki Minakami, Hiroyuki Minakami Nakano Biochemical Research Institute, Nakano Vinegar Co., Ltd., Handa-shi, Aichi 475, Japan Search for other works by this author on: Oxford Academic Google Scholar Etsuzo Entani, Etsuzo Entani Nakano Biochemical Research Institute, Nakano Vinegar Co., Ltd., Handa-shi, Aichi 475, Japan Search for other works by this author on: Oxford Academic Google Scholar Kenji Tayama, Kenji Tayama Nakano Biochemical Research Institute, Nakano Vinegar Co., Ltd., Handa-shi, Aichi 475, Japan Search for other works by this author on: Oxford Academic Google Scholar Seiichi Fujiyama, Seiichi Fujiyama Nakano Biochemical Research Institute, Nakano Vinegar Co., Ltd., Handa-shi, Aichi 475, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Masai Hiroshi Masai Nakano Biochemical Research Institute, Nakano Vinegar Co., Ltd., Handa-shi, Aichi 475, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 48, Issue 10, 1 October 1984, Pages 2405–2414, https://doi.org/10.1080/00021369.1984.10866534 Published: 01 October 1984 Article history Received: 22 September 1983 Published: 01 October 1984
Advances in the treatment of interstitial cystitis (2006)

Recent years have brought dramatic advances in the clinician's ability to offer effective pharmacotherapy to patients who have interstitial cystitis. Medical treatments have been developed and applied to reduce the interstitial cystitis symptoms of pelvic pain and urinary urgency/frequency, and to address underlying causes of the disorder. In addition, advances in the understanding of the natural history of interstitial cystitis have revealed that it is insidiously progressive and the classical definition--rare, severe and difficult to treat--is in fact the relatively uncommon, advanced stage of a disorder that affects most individuals in a mild-to-moderate and readily treatable form. This recognition has led to the identification of large numbers of previously unsuspected cases of interstitial cystitis, and the successful treatment of many individuals in the early stages of interstitial cystitis when it is far more responsive to therapy. A heparinoid-based multimodal medical regimen can effectively control symptoms and address disease pathophysiology in the majority of cases. Intravesical therapeutic solutions are new and promising adjunctive therapies that can offer immediate symptom relief during symptom flares, and for patients who are just beginning medical therapy.
Bisamidines of 2,6-diaminoanthraquinone as antiamebic agents (1978)

A series of bisamidines of 2,6-diaminoanthraquinone was synthesized and tested against cecal and hepatic forms of Entamoeba histolytica infections in rats and hamsters, respectively. A number of compounds were found to have good activity against infections in both species.
The effects of cyclic thermal loading on n-type 4H-SiC device components for EM-gun pulsers (2002)

This study developed and performed laboratory experiments which mimic the acute thermal cycling inflicted on device structures during high power switching for use in future EM-gun systems. Ni contacts to n-SiC were the device components selected for cyclic thermal testing. Modifications of the Ni-SiC materials properties in response to cyclic thermal fatigue were quantitatively assessed via Rutherford backscattering spectrometry (RBS), scanning electron microscopy (SEM), atomic force microscopy (AFM), surface profilometry, transmission electron microscopy (TEM) and nanoindentation testing. Decreases in nanohardness, elastic modulus and surface roughness were observed in response to thermal fatigue. No compositional modifications were observed at the metal-semiconductor interface. Our results demonstrated that the majority of the material changes were initiated after the first thermal pulse and that the effects of subsequent thermal cycling (up to 10 pulses) were negligible. The stability of the metal-semiconductor interface after exposure to repeated pulsed thermal cycling lends support for the utilization of Ni as a contact metallization for high power pulsed switching applications.
Intense underwater laser propagation, ionization and heating for remote shaped plasma generation (2016)

Intense underwater laser propagation, filamentation, and ionization are being investigated at NRL for many Navy applications, including remote undersea laser acoustic generation for low-frequency long-range sonar, as well as advanced micromachining using underwater laser-guided discharges. The key to low-frequency laser acoustic generation is shaping of the heated underwater volume, with more elongated volumes producing longer-duration acoustic pulses with more energy at low-frequencies.
<title>New method for nonlinear and nonstationary time series analysis: empirical mode decomposition and Hilbert spectral analysis</title> (2000)

A new method for analyzing nonlinear and nonstationary data has been developed. The key pat of the method is the Empirical Mode Decomposition method with which any complicated data set can be decomposed into a finite and often small number of Intrinsic Mode Functions (IMF). An IMF is define das any function having the same numbers of zero- crossing and extrema, and also having symmetric envelopes defined by the local maxima and minima respectively. The IMF also admits well-behaved Hilbert transform. This decomposition method is adaptive, and therefore, highly efficient. Since the decomposition is based on the local characteristic time scale of het data, it is applicable to nonlinear and nonstationary processes. With the Hilbert transform, the IMF yield instantaneous frequencies as functions of time that give sharp identifications of embedded structures. The final presentation of the result is an energy-frequency-time distribution, designated as the Hilbert Spectrum. Comparisons with Wavelet and window Fourier analysis show the new method offers much better temporal and frequency resolutions.
Dynamic Kinetic Models Capture Cell-Free Metabolism for Improved Butanol Production (2022)

ABSTRACT Cell-free systems are useful tools for prototyping metabolic pathways and optimizing the production of various bioproducts. Mechanistically-based kinetic models are uniquely suited to analyze dynamic experimental data collected from cell-free systems and provide vital qualitative insight. However, to date, dynamic kinetic models have not been applied with rigorous biological constraints or trained on adequate experimental data to the degree that they would give high confidence in predictions and broadly demonstrate the potential for widespread use of such kinetic models. In this work, we construct a large-scale dynamic model of cell-free metabolism with the goal of understanding and optimizing butanol production in a cell-free system. Using a novel combination of parameterization methods, the resultant model captures experimental metabolite measurements across two experimental conditions for nine metabolites at timepoints between 0 and 24 hours. We present analysis of the model predictions, provide recommendations for butanol optimization, and identify the aldehyde/alcohol dehydrogenase as the primary bottleneck in butanol production. Sensitivity analysis further reveals the extent to which various parameters are constrained, and our approach for probing valid parameter ranges can be applied to other modeling efforts.
Improved method of differentiation, selection and amplification of human melanocytes from the hair follicle cell pool (2012)

Hair root harbours a complex cell pool with an immense developmental potential. Several lineages, including skin, can be differentiated from the multipotent to pluripotent cells of outer root sheath (ORS) of hair follicle. Outer root sheath presents the most opulent non-invasively gained adult stem cell source known. For the purposes of cultivating melanocytes designated for graft-based treatments of depigmentation disorders, we have established an ex vivo/in vitro cultivation method by introducing several methodological improvements to the ORS explant method of Dieckmann. As a result, we gained a higher, purer yield of differentiated melanocytes in half the time (at least 10(6) of 95% pure cells in 4 weeks). This reliable cultivation procedure begins with the epilation of 60 hairs and yields high numbers of ORS melanocytes that could be used for grafting applications. The procedure not only utilises the developmental potential of hair root cell pool and favors differentiation into melanocytes, but also contributes to the general trend of minimal-to-non-invasive strategies for regenerative medicine.
<title>New Liquid Scintillators For Fiber Optic Applications</title> (1981)

New long-wavelength-emitting, high-speed, liquid scintillators have been developed and tailored specifically for plasma diagnostic experiments employing fiber optics. These scintillators offer significant advantages over commercially available plastic scintillators in terms of sensitivity and bandwidth. FWHM response times as fast as 350 ps have been measured. Emission spectra, time response data, and relative sensitivity information are presented.
<title>Algorithm for efficient segmentation and selection of representative frames in video sequences</title> (2001)

We study the problem of temporal partitioning a video sequence by blobs - the segments consisting of similar frames, and the choice of frames within the blobs well representing their content. In general, blobs give a finer subdivision of video then the shots. This problem is relevant for various applications, e.g., indexing and retrieval in video databases, or compression of video at very low bitrates. We present an efficient algorithm for the considered problem based on the use of a suitable frame distance measure reflecting similarity among the frames. Experimental results are presented.
The quest for manganese-rich electrodes for lithium batteries: strategic design and electrochemical behavior (2018)

Manganese oxides, notably γ-MnO<sub>2</sub> and modified derivatives, have played a major role in electrochemical energy storage for well over a century.
Warehousing Workflow Data: Challenges and Opportunities (2001)

Workflow management systems (WfMSs) are software platforms that allow the definition, execution, monitoring, and management of business processes. WfMSs log every event that occurs during process execution. Therefore, workflow logs include a significant amount of information that can be used to analyze process executions, understand the causes of high- and low-quality process executions, and rate the performance of internal resources and business partners. In this paper we present a packaged data warehousing solution, coupled with HP Process Manager, for collecting and analyzing workflow execution data. We first present the main challenges involved in this effort, and then detail the proposed approach. 1.