gebhart/patrepeval huggingface dataset:
Dogs with Cognitive Dysfunction as a Spontaneous Model for Early Alzheimer’s Disease: A Translational Study of Neuropathological and Inflammatory Markers (2016)

Aged companion dogs with canine cognitive dysfunction (CCD) spontaneously develop varying degrees of progressive cognitive decline and particular neuropathological features correspondent to the changes associated with Alzheimer's disease (AD) in humans. The aim of the present study was to characterize certain aspects of neuropathology and inflammatory markers related to aging and CCD in dogs in comparison with human AD. Fifteen brains from aged dogs with normal cognitive function, mild cognitive impairment, or CCD were investigated and compared with two control brains from young dogs and brain sections from human AD subjects. The neuropathological investigations included evaluation of amyloid-β (Aβ) plaque deposition (N-terminally truncated and pyroglutamyl-modified Aβ included), tau pathology, and inflammatory markers in prefrontal cortex. Cortical Aβ deposition was found to be only of the diffuse subtype as no dense-core or neuritic plaques were found. The Aβ deposition followed a progressive pattern in four maturation stages. Accumulation of the Aβ peptide was also observed in the vessel walls. Both immunohistochemically and biochemically measured levels of Aβ pathology in prefrontal cortex showed a consistent positive correlation to age but not to cognitive deficit severity. No evidence of neurofibrillary tau pathology was found. The level of pro-inflammatory cytokines was generally low and showed no significant association to cognitive status. The findings of the present study support the senescent dog with spontaneous cognitive dysfunction as a valuable non-transgenic model for further investigations of the molecular events involved in the neurodegenerative processes associated with aging and early stage AD, especially the Aβ-related pathology.
Stable pose tracking from a planar target with an analytical motion model in real-time applications (2014)

Object pose tracking from a camera is a well-developed method in computer vision. In theory, the pose can be determined uniquely from a calibrated camera. However, in practice, most real-time pose estimation algorithms experience pose ambiguity. We consider that pose ambiguity, i.e., the detection of two distinct local minima according to an error function, is caused by a geometric illusion. In this case, both ambiguous poses are plausible, but we cannot select the pose with the minimum error as the final pose. Thus, we developed a real-time algorithm for correct pose estimation for a planar target object using an analytical motion model. Our experimental results showed that the proposed algorithm effectively reduced the effects of pose jumping and pose jittering. To the best of our knowledge, this is the first approach to address the pose ambiguity problem using an analytical motion model in real-time applications.
Decentralized name-based security for content distribution using blockchains (2016)

User, content, and device names as a security primitive have been an attractive approach especially in the context of Information-Centric Networking (ICN) architectures. We leverage Hierarchical Identity Based Encryption (HIBE) to build (content) name-based security mechanisms used for securely distributing content. In contrast to similar approaches, in our system each user maintains his own Private Key Generator used for generating the master secret key and the public system parameters required by the HIBE algorithm. This way our system does not suffer from the key escrow problem, which is inherent in many similar solutions. In order to disseminate the system parameters of a content owner in a fully distributed way, we use blockchains, a distributed, community managed, global list of transactions.
SOI high voltage integrated circuit technology for plasma display panel drivers (2003)

We have developed 150 V and 250 V high voltage integrated circuit technologies using high performance extended drain MOSFET (EDMOSFET) and dielectric isolation (DI) technology for data and scan driving LSIs of color AC plasma display panel systems for an application of HDTV. The EDMOSFETs have invariant channel length despite process variation because of a self-aligned structure. This results in smaller chip area for the developed driver LSIs than that of conventional driver LSIs using LDMOSFETs. The data driver LSI with maximum driving current of 50 mA and 60 output channels can be applied to PDP systems with a fast addressing time of 0.7 /spl mu/s. The scan driver LSI for large-size AC PDPs has a maximum driving current of 500 mA for both the source and the sink.
Knowledge-based method for determining the meaning of ambiguous biomedical terms using information content measures of similarity. (2011)

In this paper, we introduce a novel knowledge-based word sense disambiguation method that determines the sense of an ambiguous word in biomedical text using semantic similarity or relatedness measures. These measures quantify the degree of similarity between concepts in the Unified Medical Language System (UMLS). The objective of this work was to develop a method that can disambiguate terms in biomedical text by exploiting similarity information extracted from the UMLS and to evaluate the efficacy of information content-based semantic similarity measures, which augment path-based information with probabilities derived from biomedical corpora. We show that information content-based measures obtain a higher disambiguation accuracy than path-based measures because they weight the path based on where it exists in the taxonomy coupled with the probability of the concepts occurring in a corpus of text.
Lanthanide‐Coordinated Semiconducting Polymer Dots Used for Flow Cytometry and Mass Cytometry (2017)

Simultaneous monitoring of biomarkers as well as single-cell analyses based on flow cytometry and mass cytometry are important for investigations of disease mechanisms, drug discovery, and signaling-network studies. Flow cytometry and mass cytometry are complementary to each other; however, probes that can satisfy all the requirements for these two advanced technologies are limited. In this study, we report a probe of lanthanide-coordinated semiconducting polymer dots (Pdots), which possess fluorescence and mass signals. We demonstrated the usage of this dual-functionality probe for both flow cytometry and mass cytometry in a mimetic cell mixture and human peripheral blood mononuclear cells as model systems. The probes not only offer high fluorescence signal for use in flow cytometry, but also show better performance in mass cytometry than the commercially available counterparts.
Probing BoNT/A Protease Exosites: Implications for Inhibitor Design and Light Chain Longevity (2014)

Botulinum neurotoxin serotype A (BoNT/A) is one of the most lethal toxins known. Its extreme toxicity is due to its light chain (LC), a zinc protease that cleaves SNAP-25, a synaptosome-associated protein, leading to the inhibition of neuronal activity. Studies on BoNT/A LC have revealed that two regions, termed exosites, can play an important role in BoNT catalytic activity. A clear understanding of how these exosites influence neurotoxin catalytic activity would provide a critical framework for deciphering the mechanism of SNAP-25 cleavage and the design of inhibitors. Herein, based on the crystallographic structure of BoNT/A LC complexed with its substrate, we designed an α-exosite binding probe. Experiments with this unique probe demonstrated that α-exosite binding enhanced both catalytic activity and stability of the LC. These data help delineate why α-exosite binding is needed for SNAP-25 cleavage and also provide new insights into the extended lifetime observed for BoNT/A LC in vivo.
A Fast Matching Algorithm Based on Adaptive Classification Scheme (2006)

This paper purposes a novel matching algorithm for image encoding using adaptive classification scheme (ACS) in fractal image compression. It processes based on standard deviation (STD) between range blocks and domain blocks. In this paper, there are two main works, i) the threshold is set to be the ratio of the STD difference and made adaptive ii) we enhance Tong's STD search algorithm by introducing a domain ACS and classification algorithm, so that domain blocks being matched with similar STD values are located directed. And finally, we present experimental results that show the efficiency of the proposed scheme. It improves the original Tong's STD algorithm without any loss in the reconstructed image quality, and the encoding time is decreased greatly based on the ACS. It is very to obtain a no search scheme for range-domain match. Also, experimental results shows that images either complex or simple can be encoded in less than 10s
Enantioselective Oxidation of Di-<i>tert</i>-Butyl Disulfide with a Vanadium Catalyst:  Progress toward Mechanism Elucidation (2002)

The mechanism of the oxidation of di-tert-butyl disulfide (1) to the chiral thiosulfinate (2) by H(2)O(2) catalyzed by bis(acetylacetonato)oxovanadium and a chiral Schiff-base ligand (3) has been investigated. Techniques included (51)V NMR spectroscopy, solvent effects on reaction enantioselectivity, and the isolation and full characterization of a 2:1 ligand-to-vanadium catalyst precursor. A model for the dramatic solvent effect on the enantioselectivity of this reaction was developed, based on the identification of a competing nonselective oxidation pathway. From this model, strategies for limiting this competing pathway were developed.
Wnt/β-Catenin Signaling Is Required to Rescue Midbrain Dopaminergic Progenitors and Promote Neurorepair in Ageing Mouse Model of Parkinson’s Disease (2014)

Wnt/β-catenin signaling is required for specification and neurogenesis of midbrain dopaminergic (mDA) neurons, the pivotal neuronal population that degenerates in Parkinson's disease (PD), and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. Wnt/β-catenin signaling plays a vital role in adult neurogenesis but whether it might engage DA neurogenesis/neurorepair in the affected PD brain is yet unresolved. Recently, the adult midbrain aqueduct periventricular regions (Aq-PVRs) were shown to harbor multipotent clonogenic neural stem/progenitor cells (mNPCs) with DA potential in vitro, but restrictive mechanisms in vivo are believed to limit their DA regenerative capacity. Using in vitro mNPC culture systems we herein demonstrate that aging is one most critical factor restricting mNPC neurogenic potential via dysregulation of Wnt/β-catenin signaling. Coculture paradigms between young/aged (Y/A) mNPCs and Y/A astrocytes identified glial age and a decline of glial-derived factors including Wnts as key determinants of impaired neurogenic potential, whereas Wnt activation regimens efficiently reversed the diminished proliferative, neuronal, and DA differentiation potential of A-mNPCs. Next, in vivo studies in wild (Wt) and transgenic β-catenin reporter mice uncovered Wnt/β-catenin signaling activation and remarkable astrocyte remodeling of Aq-PVR in response to MPTP-induced DA neuron death. Spatio-temporal analyses unveiled β-catenin signaling in predopaminergic (Nurr1(+)/TH(-)) and imperiled or rescuing DAT(+) neurons during MPTP-induced DA neuron injury and self-repair. Aging inhibited Wnt signaling, whereas β-catenin activation in situ with a specific GSK-3β antagonist promoted a significant degree of DA neurorestoration associated with reversal of motor deficit, with implications for neurorestorative approaches in PD.
Oncogenes and tumour suppressor genes in first trimester human fetal gonadal development (1999)

Tumour suppressor genes and oncogenes that control proliferation and apoptosis are known to play an important role in embryogenesis, second trimester fetal oocyte loss, adult ovulation, and in adult male testicular degeneration. We have examined tumour suppressor genes, oncogenes and oestrogen receptors during first trimester human gonadal differentiation to investigate their role at this crucial phase in development. Immunohistochemistry was used to localize the gene products of Bcl-2, c-erB-2, c-myc, p53, nm23 and oestrogen receptor. As gonadal development occurred at 6-12 weeks gestation, a changing pattern of expression was observed that varied in different cell types. The oestrogen receptor was not present in oogonia, spermatogonia and supporting cells during the first trimester. This study highlights the importance of oncogenes and tumour suppressor genes in first trimester gonadal development.
Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions (1992)

The reactions involved in the bacterial metabolism of naphthalene to salicylate have been reinvestigated by using recombinant bacteria carrying genes cloned from plasmid NAH7. When intact cells of Pseudomonas aeruginosa PAO1 carrying DNA fragments encoding the first three enzymes of the pathway were incubated with naphthalene, they formed products of the dioxygenase-catalyzed ring cleavage of 1,2-dihydroxynaphthalene. These products were separated by chromatography on Sephadex G-25 and were identified by 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry as 2-hydroxychromene-2-carboxylate (HCCA) and trans-o-hydroxybenzylidenepyruvate (tHBPA). HCCA was detected as the first reaction product in these incubation mixtures by its characteristic UV spectrum, which slowly changed to a spectrum indicative of an equilibrium mixture of HCCA and tHBPA. Isomerization of either purified product occurred slowly and spontaneously to give an equilibrium mixture of essentially the same composition. tHBPA is also formed from HCCA by the action of an isomerase enzyme encoded by plasmid NAH7. The gene encoding this enzyme, nahD, was cloned on a 1.95-kb KpnI-BglII fragment. Extracts of Escherichia coli JM109 carrying this fragment catalyzed the rapid equilibration of HCCA and tHBPA. Metabolism of tHBPA to salicylaldehyde by hydration and aldol cleavage is catalyzed by a single enzyme encoded by a 1-kb MluI-StuI restriction fragment. A mechanism for the hydratase-aldolase-catalyzed reaction is proposed. The salicylaldehyde dehydrogenase gene, nahF, was cloned on a 2.75-kb BamHI fragment which also carries the naphthalene dihydrodiol dehydrogenase gene, nahB. On the basis of the identification of the enzymes encoded by various clones, the gene order for the nah operon was shown to be p, A, B, F, C, E, D.
Framework for Designing and Evaluating Game Achievements (2011)

This paper presents a framework for evaluating and designing game design patterns commonly called as “achievements”. The results are based on empirical studies of a variety of popular achievement systems. The results, along with the framework for analyzing and designing achievements, present two definitions of game achievements. From the perspective of the achievement system, an achievement appears as a challenge consisting of a signifying element, rewards and completion logics whose fulfilment conditions are defined through events in other systems (usually games). From the perspective of a single game, an achievement appears as an optional challenge provided by a meta-game that is independent of a single game session and yields possible reward(s).
Integrated access: the achievement of a vision (2002)

The authors highlight many of the open challenges to fulfilment of the technical specification for TR-303. The telephone operating companies have a vision of integrated access that focuses on increased revenues at a reduced cost in a timely fashion. TR-303 is a technical solution that begins to address many of the issues embodied in this vision. While there are many technical challenges, the key to the timely introduction of TR-303 technology is compatibility with the existing investment in operations systems (OSs), local digital switches (LDSs) and digital loop carrier systems. TR-303 will begin with a core feature set that will be proven in close interaction between the LDS and the remote digital terminal. The existence of working TR-303 systems in the network, working with existing OSs, will provide a springboard for new OS functionality as well as providing a stable interface for development.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015)

Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome, an autism spectrum-associated disorder with a host of neurological and sensory symptoms, but the pathogenic mechanisms remain elusive. Neuronal circuits are shaped by experience during critical periods of heightened plasticity. The maturation of cortical GABA inhibitory circuitry, the parvalbumin(+) (PV(+)) fast-spiking interneurons in particular, is a key component that regulates the initiation and termination of the critical period. Using MeCP2-null mice, we examined experience-dependent development of neural circuits in the primary visual cortex. The functional maturation of parvalbumin interneurons was accelerated upon vision onset, as indicated by elevated GABA synthetic enzymes, vesicular GABA transporter, perineuronal nets, and enhanced GABA transmission among PV interneurons. These changes correlated with a precocious onset and closure of critical period and deficient binocular visual function in mature animals. Reduction of GAD67 expression rescued the precocious opening of the critical period, suggesting its major role in MECP2-mediated regulation of experience-driven circuit development. Our results identify molecular changes in a defined cortical cell type and link aberrant developmental trajectory to functional deficits in a model of neuropsychiatric disorder.
Fingerprint template protection schemes: A literature review (2018)

The fingerprint is the most widely used technology for identification or authentication systems, which can be known as fingerprint authentication systems (FAS).In addition to providing security, the fingerprint is also easy to use, very reliable and has a high accuracy for identity recognition. FAS is still exposed to security attacks because fingerprint information is unencrypted.Therefore, fingerprint information requires protection known as fingerprint template protection (FTP).This paper aims to provide an organized literature on FTP.Three research questions were formulated to guide the literature analysis.First, this analysis focuses on the types of FTP schemes; second, the metrics used for evaluating the FTP schemes; and finally, the common datasets used for evaluating the FTP schemes. The latest information and references are analysed and classified based on FTP methods and publication year to obtain information related to the development and application of FTP.This study mainly surveyed 62 documents reported on FTP schemes between the year 2000 and 2017.The results of this survey can be a source of reference for other researchers in finding literature relevant to the FTP.
Prior information and uncertainty in inverse problems (2000)

Abstract Solving any inverse problem requires understanding the uncertainties in the data to know what it means to fit the data. We also need methods to incorporate data-independent prior information to eliminate unreasonable models that fit the data. Both of these issues involve subtle choices that may significantly influence the results of inverse calculations. The specification of prior information is especially controversial. How does one quantify information? What does it mean to know something about a parameter a priori? In this tutorial we discuss Bayesian and frequentist methodologies that can be used to incorporate information into inverse calculations. In particular we show that apparently conservative Bayesian choices, such as representing interval constraints by uniform probabilities (as is commonly done when using genetic algorithms, for example) may lead to artificially small uncertainties. We also describe tools from statistical decision theory that can be used to characterize the performance of inversion algorithms.
Relaxing Bijectivity Constraints with Continuously Indexed Normalising Flows (2020)

We show that normalising flows become pathological when used to model targets whose supports have complicated topologies. In this scenario, we prove that a flow must become arbitrarily numerically noninvertible in order to approximate the target closely. This result has implications for all flow-based models, and especially Residual Flows (ResFlows), which explicitly control the Lipschitz constant of the bijection used. To address this, we propose Continuously Indexed Flows (CIFs), which replace the single bijection used by normalising flows with a continuously indexed family of bijections, and which can intuitively clean up mass that would otherwise be misplaced by a single bijection. We show theoretically that CIFs are not subject to the same topological limitations as normalising flows, and obtain better empirical performance on a variety of models and benchmarks.
Association between Critical Thinking Disposition and Grade Point Average Score in Dental Hygiene Students (2012)

Critical thinking is a essential competency for dental hygiene education and practice. The purpose of this study was to examine critical thinking disposition between groups classified by GPA score in two dental hygiene educational program. A total 252 dental hygiene students responded. The study extracted six dimensions(intellectual eagerness/curiosity, prudence, healthy skepticism, intellectual integrity, objectivity, self-confidence) derived from 27 items with the exception of systematicity using factor analysis. The mean score for critical thinking disposition was 3.47 on a 5 point scale. The result showed a statistically significant correlation critical thinking disposition and age. Multivariate analysis of covariance(MANCOVA) was used to compare six subscales between the three groups. MANCOVA results revealed that intellectual eagerness/curiosity for three groups were significantly different(Wilks's lamda=0.914, F(6, 24)=1.869), p=0.01, partial eta square=0.044). Multiple comparison for intellectual eagerness/curiosity by Scheffe's method showed differences between high score group and mid score group(p=0.027), high score group and low score group(p=0.002). In this study, academic achievement and critical thinking tends to show significant correlations is known. Critical thinking skills by examining the actual grade compares the difference in propensity scores according to a case study in intellectual curiosity, passion, and could tell the difference to appear.
Pomegranate (Punica granatum L.): A medicinal plant with myriad biological properties - A short review (2010)

The pomegranate, Punica granatum L., which can be found throughout the Mediterranean region, in Southeast Asia, California and Arizona in USA was in ancient times referred as possessing powers of fertility, abundance and good luck (fruit). The biological properties of extracts (antimicrobial, antioxidant, anticancer, anti-inflammatory, among other properties) obtained from several parts of pomegranate is reported in the present work. Due to such properties, the extracts have been used in therapeutics, such as in the prevention of infection, inflammation, cancer, among other applications. However, other aspects are also referred in the present work such as the good practices of culture and fruit preservation, search of new compounds, selection of cultivars through biotechnological techniques for obtaining juice or fruits ready to eat. Such compilation of information was based on the search in the ISI Web of Knowledge (Thomson Reuters) from 2009 up to the beginning of October 2010.

	 

	Key words: Punica granatum L., polyphenols, biological activities.