gebhart/patrepeval huggingface dataset:
The Variable Stiffness Actuator vsaUT-II: Mechanical Design, Modeling, and Identification (2013)

In this paper, the rotational variable stiffness actuator vsaUT-II is presented. This actuation system is characterized by the property that the apparent stiffness at the actuator output can be varied independently from its position. This behavior is realized by implementing a variable transmission ratio between the internal elastic elements and the actuator output, i.e., a lever arm with variable pivot point position. The pivot point is moved by a planetary gears mechanism, which acquires a straight motion from only rotations, thereby providing a low-friction transmission. The working principle details of the vsaUT-II are elaborated and the design is presented. The actuator dynamics are described by means of a lumped parameter model. The relevant parameters of the actuator are estimated and identified in the physical setup and measurements are used to validate both the design and the derived model.
Hybrid Pattern Matching/TDOA Positioning Method for CDMA Networks (2007)

In this paper hybrid pattern matching (PM) and time difference of arrival (TDOA) positioning method is proposed to improve a position accuracy of mobile station (MS) in CDMA networks where GPS is not satisfactory. Iterative TDOA method is used for its high accuracy and good robustness. Since the performance of iteration method depends highly on the initial estimation, the proposed method uses the location information from PM to estimate initial value. There is no need to change the hardware of MS. PM's results and other data such as received signal value, time delay are measured by using diagnostic monitoring (DM) software in real environment. The results show that proposed method can provide a better accuracy than conventional PM algorithm.
Structure-activity study of S-1358 and its derivatives. II. Structure modifications of S-n-butyl S'-p-tert-butylbenzyl N-3-pyridyldithiocarbonimidate (S-1358, Denmert) and fungicidal activities. (1977)

Since S-n-butyl S'-p-tert-butylbenzyl N-3-pyridyldithiocarbonimidate, a potent fungicide to powdery mildew, is known to inhibit ergosterol biosynthesis in Monilinia fructigena, the activities were assessed on 24 compounds having other substituents than the 3-pyridyl and on 24 compounds having a variety of different structures connecting the 3-pyridyl and the p-tert-butylphenyl group from that of the dithiocarbonimidate. In the former group the 3-pyridyl group was essential for the activities and the substitution at the 2- or 6-position resulted, on available data, in inactive compounds. Several other β-N-heterocyclic analogs were also active. In the latter group, a number of modified compounds from the dithiocarbonimidate structure were shown to be active.
Fabrication and interface reaction of Y-Ba-Cu-O superconducting thin films by reactive ion beam coating (1989)

Y-Ba-Cu-O superconducting thin films have been fabricated by the reactive ion beam coating technique with good reproducibility. The influence of atom stoichiometry on the critical temperatures of the films is determined. Ba and Cu atoms diffusing into substrates were detected by auger electron spectroscopy and Rutherford backscattering. A thin silver film deposited on ZrO/sub 2/ substrate as a buffer layer can effectively retard the interface reaction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Telomerase Inhibitors from Natural Products and Their Anticancer Potential (2017)

Telomeres and telomerase are nowadays exploring traits on targets for anticancer therapy. Telomerase is a unique reverse transcriptase enzyme, considered as a primary factor in almost all cancer cells, which is mainly responsible to regulate the telomere length. Hence, telomerase ensures the indefinite cell proliferation during malignancy-a hallmark of cancer-and this distinctive feature has provided telomerase as the preferred target for drug development in cancer therapy. Deactivation of telomerase and telomere destabilization by natural products provides an opening to succeed new targets for cancer therapy. This review aims to provide a fundamental knowledge for research on telomere, working regulation of telomerase and its various binding proteins to inhibit the telomere/telomerase complex. In addition, the review summarizes the inhibitors of the enzyme catalytic subunit and RNA component, natural products that target telomeres, and suppression of transcriptional and post-transcriptional levels. This extensive understanding of telomerase biology will provide indispensable information for enhancing the efficiency of rational anti-cancer drug design.
The technique improvement of producing dioctyl terephthalate (2006)

In this paper, the enterifying technique of circumfluence for producing DOTP by TPA methord was improved. At the same time, it is discussed how to incress speed of producing DOTP.
Synthesis and Characterization of Salicylic Acid-Based Poly(Anhydride-Ester) Copolymers (2006)

A series of poly(anhydride-esters) based on poly(1,10-bis(<i>o</i>-car-boxyphenoxy)decanoate) (CPD) and poly(1,6-bis(<i>p</i>-carboxyphenoxy)hexane) (<i>p</i>-CPH) were synthesized by melt-condensation polymerization. Poly-(anhydride-esters) that contain CPD hydrolytically degraded into salicylic acid, however, these homopolymers have mechanical and thermal characteristics that limit their use in clinical applications. The synthesis and characterization of copolymers of CPD with <i>p</i>-CPH, a monomer known to generate mechanically stable homopolymers, was investigated. By changing the CPD to <i>p</i>-CPH monomer ratios, the salicylic acid loading and thermal/mechanical properties of the copolymers was a controlling factor; increasing the CPD concentration increased the salicylate loading but decreased the polymer stability; whereas increasing the <i>p</i>-CPH concentration increased the thermal and mechanical stability of the copolymers. Specifically, decreasing the CPD:<i>p</i>-CPH ratio resulted in lower salicylate loading and increased thermal decomposition temperatures. The glass transition temperatures (°C) varied from 27 to 38°C, a desirable range for elastomeric biomedical implants.
Autologous bone marrow transplantation for patients with acute lymphoblastic leukemia in second or subsequent remission: results of bone marrow treated with monoclonal antibodies BA-1, BA-2, and BA-3 plus complement (1985)

Abstract Autologous bone marrow transplantation (BMT) was utilized as therapy for 23 patients with acute lymphoblastic leukemia (ALL) in second or greater remission. Bone marrow was treated in vitro with a combination of monoclonal antibodies, consisting of BA-1, BA-2, BA-3, and baby rabbit complement (BRC'). All patients were prepared for transplantation with cyclophosphamide and fractionated total body irradiation. Engraftment occurred in all 23 patients. Seven of 23 patients remain relapse-free from six to 32 months (median, 21.4 months) posttransplant. Failures were due to relapse with the exception of one patient who died of infection. This study demonstrates that autologous BMT using in vitro marrow treatment with BA-1, BA-2, BA-3, and BRC' is safe, allows engraftment, and results in prolonged survival for some patients with ALL in second or greater remission.
Neptune: above-ground storage tank inspection robot system (1995)

The Neptune system allows unmanned entry and sensor data collection in above-ground storage tanks (ASTs). The sensors are immersed in the petroleum product and uses video and ultrasonics to ascertain from the inside-out the state of corrosion of the floor and side-walls. This eliminates the need to empty or clean the tanks and also avoids the required human walk-through inspection, which results in a very sparse data set from which the tank's state must be statistically extrapolated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Transepithelial paracellular leakiness induced by chronic phorbol ester exposure correlates with polyp-like foci and redistribution of protein kinase C-alpha (1997)

Although exposure of LLC-PK1 epithelial cell sheets to phorbol esters (TPA) causes a near immediate and total decrease of transepithelial electrical resistance (TER), continuation of exposure for 3 to 4 days results in a tachyphylactic response as TER begins to return to control levels. Recovery of TER is maximal by 5 to 6 days, but reaches only 70 to 80% of control level. A reciprocal change in the transepithelial flux of D-mannitol indicates that the TER decrease is indicative of an increase in tight junction permeability. Exposure of cell sheets to TPA for several days also results in the appearance of multilayered polyp-like foci (PLFs) across the otherwise one cell layer thick cell sheets. The pattern of penetration of the electron dense dye, ruthenium red, from the apical surface, across the tight junction and into the lateral intercellular space indicates that the tight junctions of the cell sheet become uniformly leaky after acute exposure to TPA. However, when exposure is continued for several days, only the junctions of cells in the PLFs manifest leakiness. The decrease in TER following acute TPA exposure correlates with the translocation of protein kinase C-alpha (PKC alpha) into a membrane-associated compartment. With exposure of several days, only a trace of PKC alpha is visible by Western immunoblot, and this is in the membrane-associated compartment. Immunofluorescent microscopy indicates that the trace of PKC alpha seen in the Western immunoblots is ascribable distinctly to cells of the PLFs. Monolayer areas between PLFs show no discernible immunofluorescent signal. The data therefore indicate that tight junction barrier function may be restored in certain areas by the down regulation of PKC alpha from the membrane-associated compartment. Failure to down regulate may result in the paracellular leakiness and abnormal cell architecture of the PLFs. Possible implications of this model for in vivo epithelial tumor promotion are discussed.
Sulfur Vulcanization of Natural Rubber for Benzothiazole Accelerated Formulations: From Reaction Mechanisms to a Rational Kinetic Model (2003)

Abstract The chemistry of accelerated sulfur vulcanization is reviewed and a fundamental kinetic model for the vulcanization process is developed. The vulcanization of natural rubber by the benzothiazolesulfenamide class of accelerators is studied, where 2-(morpholinothio) benzothiazole (MBS) has been chosen as the representative accelerator. The reaction mechanisms that have been proposed for the different steps in vulcanization chemistry are critically evaluated with the objective of developing a holistic description of the governing chemistry, where the mechanisms are consistent for all reaction steps in the vulcanization process. A fundamental kinetic model has been developed for accelerated sulfur vulcanization, using population balance methods that explicitly acknowledge the polysulfidic nature of the crosslinks and various reactive intermediates. The kinetic model can accurately describe the complete cure response including the scorch delay, curing and the reversion for a wide range of compositions, using a single set of rate constants. In addition, the concentration profiles of all the reaction intermediates as a function of polysulfidic lengths are predicted. This detailed information obtained from the population balance model is used to critically examine various mechanisms that have been proposed to describe accelerated sulfur vulcanization. The population balance model provides a quantitative framework for explicitly incorporating mechanistically reasonable chemistry of the vulcanization process.
New Enzyme Immunoassays for Sensitive Detection of Circulating <i>Candida albicans</i> Mannan and Antimannan Antibodies: Useful Combined Test for Diagnosis of Systemic Candidiasis (1999)

Two standardized enzyme immunoassays for the serological diagnosis of candidiasis were developed. The first one detects antimannan antibodies, while the second one detects mannan with a sensitivity of 0.1 ng/ml. These tests were applied to 162 serum samples retrospectively selected from 43 patients with mycologically and clinically proven candidiasis caused by Candida albicans. Forty-three serum samples were positive for mannan, and 63 had significant antibody levels. Strikingly, only five serum samples were simultaneously positive by both tests. When the results were analyzed per patient, 36 (84%) presented at least one serum positive by one test. For 30 of them, positivity by one test was always associated with negative results by the other test for any of the tested sera. For six patients whose sera were positive for either an antigen or an antibody response, a balance between positivity by each test was evidenced by kinetic analysis of sera drawn during the time course of the infection. Controls consisted of 98 serum samples from healthy individuals, 93 serum samples from patients hospitalized in intensive care units, and 39 serum samples from patients with deep mycoses. The sensitivities and specificities were 40 and 98% and 53 and 94% for mannanemia or antibody detection, respectively. These values reached 80 and 93%, respectively, when the results of both tests were combined. These observations, which clearly demonstrate a disparity between circulation of a given mannan catabolite and antimannan antibody response, suggest that use of both enzyme immunoassays may be useful for the routine diagnosis of candidiasis.
Triangular lattice of carbon nanotube arrays for negative index of refraction and subwavelength lensing effect (2005)

Self-assembly of polystyrene microspheres has been utilized in a two-step masking technique to prepare triangular lattices of catalytic nanodots at low cost. Subsequent triangular lattices of aligned carbon nanotubes on a silicon substrate are achieved by plasma-enhanced chemical vapor deposition. Nickel is used both in the nanodots and in the secondary mask. The triangular lattices of carbon nanotube arrays as two-dimensional photonic crystals show higher geometrical symmetry than the hexagonal lattices previously reported, enabling broader applications including negative index of refraction and subwavelength lensing effect.
The Transient Phase Between Growth and Nongrowth of Heterotrophic Bacteria, with Emphasis on the Marine Environment (1987)

INTRODUCTION 26 INTERMITI'ENT GROWTH OF MARINE BACTERIA 27 Bacterial Production and Predation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Nutritional Diversity of Marine Bacteria. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..... . . . . . 27 Influence of Surface Attachment . . . . . . . ..... 28 A Proposed Life Cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 THE TRANSIENT PHASE BETWEEN GROWTH AND NONGROWTH 30 Formation and Presence of Small Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Bacterial Surface Characteristics and Adhesion 31 MECHANISMS OF STARVATION SURVIVAL 32 Nonmarine Bacteria . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Marine Bacteria 36
Analysis on gene mutations of #beta#-thalassemia in Jiangxi area (2002)

To analyze #beta#-globin genes of 136 chromosomes of 35 cases with severe #beta#-thalassemia and their parents with the technique of PCR combined reverse dot blot (RDB). 6 types of mutation were identified: IVS2nt-654 (C→T), CD41-42(-TCTT), CD17(A→T), TATA box-28(A→G), CD71-72(+A), CD27-28(+C), CD71-72(+A), composed rate are 0.3971, 0.2794, 0.125, 0.1176, 0.0515, 0.0294. The study results are significant for developing hevedisy consult, gene analysis and prenatal diagnosis in this area.
Glycomic and Glycoproteomic Analysis of Serum from Patients with Stomach Cancer Reveals Potential Markers Arising from Host Defense Response Mechanisms (2010)

Despite the reduced incidence of gastric cancer in the developed world, a diagnosis of stomach carcinoma still carries a poor prognosis due to the asymptomatic nature of the disease in the early stages, subsequent advanced stage diagnosis, and a low 5 year survival rate. Endoscopy remains the primary standard for diagnosis of stomach carcinoma and the current marker, carbohydrate antigen 19-9 (CA19-9) lacks the levels of sensitivity and specificity required in order to make it clinically useful for diagnostic monitoring. Therefore, there is a current need for additional markers to improve the diagnostic accuracy for the early stages of stomach cancer. Together, glycomic, proteomic, and glycoproteomic analyses of serum have the potential to identify such probable markers. A discovery study is reported here using preoperative serum from 80 stomach cancer patients, 10 patients bearing benign stomach disease, and 20 matched controls. Glycomic analysis of the total and immunoaffinity depleted serum revealed statistically significant increases in the levels of sialyl Lewis X epitopes (SLe(X)) present on triantennary glycans accompanied by increased levels of core fucosylated agalactosyl biantennary glycans present on IgG (referred to as the IgG G0 glycoform) which are associated with increasing disease pathogenesis. Protein expression analysis using 2D-DiGE returned a number of differentially expressed protein candidates in the depleted serum, many of which were shown to carry triantennary SLe(X) during subsequent glycomic investigations. Biological pathway analysis of the experimental data returned complement activation and acute phase response signaling as the most significantly altered pathways in the stomach cancer patient serum. Upon the basis of these findings, it is suggested that increased expression of IgG G0 and complement activation are a host response to the presence of the stomach tumor while the increased expression of SLe(X) and acute phase response proteins is a result of pro-inflammatory cytokine signaling, including IL-6, during carcinogenesis. The approach presented herein provides an insight into the underlying mechanisms of disease and the resulting changes in the glycome and glycoproteome offer promise as potential markers for diagnosis and prognostic monitoring in stomach cancer.
Morphine modulates doxorubicin uptake and improves efficacy of chemotherapy in an intracranial xenograft model of human glioblastoma. (2016)

Morphine may alter the permeability of Blood-Brain Barrier (BBB), enhancing the access of molecules normally unable to cross it, as Doxorubicin (Dox). In addition, morphine seems to mediate the uptake of Dox into the brain by its reduced efflux mediated by P-glycoprotein (P-gp). We evaluated the antitumor efficacy of Dox plus morphine treatment by an orthotopic glioblastoma xenograft model. Foxn1 mice were injected with U87MG-luc cells in the left lobe of the brain and treated with Dox (5 mg/kg and 2.5 mg/kg, weekly) with or without morphine pretreatment (10 mg/kg, weekly). Bioluminescence imaging (BLI) was used to monitoring tumor growth and response to therapy. Additionally, we investigated the role of morphine on the uptake of Dox by MDCKII cells transfected with human MDR1 gene encoding for P-gp. The data demonstrate that only Dox 5 mg/kg determined a significant tumor regression while the lower dose (2.5 mg/kg) was not effective. However, if combined with morphine, the group treated with Dox 2.5 mg/kg showed a decreasing tumor growth. The average BLI for Dox 2.5 mg/kg plus morphine was 5 fold lower than Dox 2.5 mg/kg alone (P=0.0053) and 8 fold lower than vehicle (P=0.0004). Additionally, Dox increased in MDCKII-P-gp transfected cells only in the presence of morphine with a significantly higher level comparing control group (3.84) vs Dox plus morphine group (12.29, P<0.05). Our results indicate that Dox alone and in combination with morphine appear to be effective in controlling the growth of glioblastoma in a xenograft mouse model.
Performance Evalution Analysis for College Teachers Based on Weighted Idealpoint (2012)

The evaluation methods of college teachers’ performance should be scientific and feasible. To accomplish this goal, we design the performance evaluation index system from three aspects as teaching, scientific research and professional disciplines development. By using the principal component analysis method we reduce the data dimension, through combining with the weighted idealpoint method, we get the final ranking result. Finally, an example is given to show the rationality and effect of the evaluation method. Key words : College teachers; Performance evaluation method; Principal component analysis method; Weighted ideal-point method
Fermentation properties and potential prebiotic activity of Bimuno<sup>®</sup>galacto-oligosaccharide (65 % galacto-oligosaccharide content) on<i>in vitro</i>gut microbiota parameters (2016)

Prebiotic oligosaccharides have the ability to generate important changes in the gut microbiota composition that may confer health benefits to the host. Reducing the impurities in prebiotic mixtures could expand their applications in food industries and improve their selectivity and prebiotic effect on the potential beneficial bacteria such as bifidobacteria and lactobacilli. This study aimed to determine the in vitro potential fermentation properties of a 65 % galacto-oligosaccharide (GOS) content Bimuno® GOS (B-GOS) on gut microbiota composition and their metabolites. Fermentation of 65 % B-GOS was compared with 52 % B-GOS in pH- and volume-controlled dose-response anaerobic batch culture experiments. In total, three different doses (1, 0·5 and 0·33 g equivalent to 0·1, 0·05 and 0·033 g/l) were tested. Changes in the gut microbiota during a time course were identified by fluorescence in situ hybridisation, whereas small molecular weight metabolomics profiles and SCFA were determined by 1H-NMR analysis and GC, respectively. The 65 % B-GOS showed positive modulation of the microbiota composition during the first 8 h of fermentation with all doses. Administration of the specific doses of B-GOS induced a significant increase in acetate as the major SCFA synthesised compared with propionate and butyrate concentrations, but there were no significant differences between substrates. The 65 % B-GOS in syrup format seems to have, in all the analysis, an efficient prebiotic effect. However, the applicability of such changes remains to be shown in an in vivo trial.