gebhart/patrepeval huggingface dataset:
2-Phosphino- and 2-phosphinylbenzenethiols: new ligand types (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Phosphino- and 2-phosphinylbenzenethiols: new ligand typesEric Block, Gabriel Ofori-Okai, and Jon ZubietaCite this: J. Am. Chem. Soc. 1989, 111, 6, 2327–2329Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00188a071https://doi.org/10.1021/ja00188a071research-articleACS PublicationsRequest reuse permissionsArticle Views2700Altmetric-Citations120LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Measuring the Performance of Value Management Studies in Construction: Critical Review (2006)

Value management (VM) is a useful method to use when dealing with issues such as budget and schedule challenges arising in the construction industry. However, little research has been done to measure the performance of VM studies, which has made many potential users reluctant to use VM. This paper presents a critical review of the development of performance measurement in general and the performance measurement in the construction industry, with a special focus on the performance measurement of VM studies in construction. The strengths and weaknesses of the existing measurement frameworks are investigated in the context of VM studies. It is concluded that traditional performance measurement of VM studies focusing on cost reduction is insufficient. Many other perspectives, such as clarifying objectives, and improving communication among stakeholders, should be considered seriously when making the measurement. This paper reveals that the existing frameworks to measure VM studies are inappropriate. It suggests that perspectives such as multicriteria measurement, flexible framework for different practice, and benchmarking to identify best practice could be adapted to develop a performance measurement framework for VM studies.
657-P: The National Diabetes Prevention Program: Does Start Date Matter? (2020)

The National Diabetes Prevention Program (National DPP) is a partnership of public and private organizations working together to build a nationwide infrastructure to deliver a lifestyle change program proven to prevent or delay onset of type 2 diabetes in adults with prediabetes. Much variability exists in the number of days participants stay in the 12-month program. Of the 217,585 eligible participants enrolled in in-person and online organizations as of October 2019, the average length of stay in the program was 163 days (210 for in-person, 134 for online) with interquartile range of 238 (231 for in-person, 161 for online). The reasons for leaving the program are not collected; only information such as participant demographics, type of program delivery (in-person or online), and date of the first session attended can be assessed. To determine whether retention is related to the time of year a participant enters the program, a seasonal model was applied, where the response variable was the number of days a participant stayed in the program. Separate models were run for all participants, and by sex and delivery mode, to look at the impact of start date on retention. Overall, participants who started the program on day 267 (September) were predicted to stay in the program longest: 178 days (95% CI: 176, 179). The range of predicted days was 137-178. Longest predicted number of days in the program for men and women was 161 (158, 164) and 182 (180,184), respectively, and was also associated with September start dates. In-person participants who started on day 270 (September) were predicted to have the longest stay, 218 (216, 220) with range of 192-218. Estimates for online participants showed a maximum of 142 days (140, 144), which was associated with start dates in June (day 163) and had a range of 128-142. All models predicted that the shortest stay in the program was associated with starting in November. Retention is strongly associated with enrollment timing; this information may be helpful as organizations plan future classes. Disclosure E. Ely: None. M. Bell: None.
Essential System Administration Pocket Reference (2002)

From the Publisher:
This pocket reference brings together all the important Unix and Linux system administration information in a single, compact volume. Not only are all of the important administrative commands covered, but this reference also includes the locations and formats of important configuration files (including both general system databases like the password and group files as well as the configuration files for major subsystems like DNS, DHCP, and sendmail). In addition, variations in command usage and file formats are included for the most important Unix versions. When you get a new system running a different Unix operating system, all the information you need will already be at your fingertips.
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase (2000)

Modifier screens have been powerful genetic tools to define signaling pathways in lower organisms. The identification of modifier loci in mice has begun to allow a similar dissection of mammalian signaling pathways. Transgenic mice (Btk(lo)) expressing 25% of endogenous levels of Bruton's tyrosine kinase (Btk) have B cell functional responses between those of wild-type and Btk(-/-) mice. We asked whether reduced dosage or complete deficiency of genes previously implicated as Btk regulators would modify the Btk(lo) phenotype. We used two independent assays of Btk-dependent B cell function. Proliferative response to B cell antigen receptor cross-linking in vitro was chosen as an example of a relatively simple, well-defined signaling system. In vivo response to type II T-independent antigens (TI-II) measures complex interactions among multiple cell types over time and may identify additional Btk pathways. All modifiers identified differentially affected these two assays, indicating that Btk mediates these processes via distinct mechanisms. Loss of Lyn, PTEN (phosphatase and tensin homolog), or SH2-containing inositol phosphatase suppressed the Btk(lo) phenotype in vitro but not in vivo, whereas CD19 and the p85alpha form of phosphoinositide 3-kinase behaved as Btk(lo) enhancers in vivo but not in vitro. Effects of Lyn, PTEN, or p85alpha haploinsufficiency were observed. Haploinsufficiency or complete deficiency of protein kinase C beta, Fyn, CD22, Galphaq, or Galpha11 had no detectable effect on the function of Btk(lo) B cells. A transgenic system creating a reduction in dosage of Btk can therefore be used to identify modifier loci that affect B cell responses and quantitatively rank their contribution to Btk-mediated processes.
Clinical Assessment of Cardiovascular Disorders by Cardiac Biomarkers (2014)

Cardiovascular diseases (CVD) are the primary cause of morbidity and mortality in the country. Therefore, Blood cardiac biomarkers (CB) have become progressively more accurate for estimating cardiac abnormalities for the last 40 years. Biomarkers are a significant tool to better identify high-risk individuals, to diagnose disease conditions promptly and accurately, and to efficiently prognosticate and treat patients with disease. Various biomarkers have been developed to assess cardiotoxicity which arises due to chemotherapy treatment, complications from anorexia nervosa, adverse effects of heavy metals intake, or an incorrectly administered drug such as bupivacaine. Biomarkers like miRNAs are potentially new biomarker agents having the benefits of both tissue and disease specific expression mark. Secreted miRNAs are protected from degradation by ribonucleases, RNA-binding proteins and lipid vehicles. All of these qualities equate to miRNAs being very attractive as diagnostic biomarkers. Another developed biomarker is Glycogen phosphorylase isoenzyme BB, Soluble CD40 ligand, ST2, ET1/CTproET1, exosomes as biomarkers of disease. Furthermore, new molecular diagnostics techniques are also available to access various cardiac related maladies like cardiomyopathy, heart failure and arrhythmia. Like Endomyocardial biopsy (EMB), Immunoassay, Histological Analysis, Immunohistochemical Examination on Intramyocardial Inflammation, Molecular Virology for detection of Myocardial Infarctions, Indirect Immunofluorescence testing of Autoimmunity, Proof of disease-related gene mutations for Cardiomyopathies, Diagnosticbased treatment decisions are the various techniques to access cardiac disorders.
What Vulnerability Do We Need to Patch First? (2014)

Computing a prioritized set of vulnerabilities to patch is important for system administrators to determine the order of vulnerabilities to be patched that are more critical to the network security. One way to assess and analyze security to find vulnerabilities to be patched is to use attack representation models (ARMs). However, security solutions using ARMs are optimized for only the current state of the networked system. Therefore, the ARM must reanalyze the network security, causing multiple iterations of the same task to obtain the prioritized set of vulnerabilities to patch. To address this problem, we propose to use importance measures to rank network hosts and vulnerabilities, then combine these measures to prioritize the order of vulnerabilities to be patched. We show that nearly equivalent prioritized set of vulnerabilities can be computed in comparison to an exhaustive search method in various network scenarios, while the performance of computing the set is dramatically improved, while equivalent solutions are computed in various network scenarios.
Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1 (1998)

Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel ligand peptide for integrin alpha5 beta1, which blocks alpha5 beta1-mediated cell adhesion to fibronectin (Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J. Cell Biol. 124, 373-380). Here we have localized the binding site for RRETAWA on alpha5 beta1 using inhibitory monoclonal antibodies (mAbs) and site-directed mutagenesis. A cyclic peptide containing this sequence (*CRRETAWAC*) had little effect on the binding of most anti-alpha5 and anti-beta1 mAbs to alpha5 beta1 but completely blocked binding of the anti-alpha5 mAb 16 in a directly competitive manner. Hence, the binding site of RRETAWA appears to closely overlap with the epitope of mAb 16. *CRRETAWAC* also acted as a direct competitive inhibitor of the binding of Arg-Gly-Asp (RGD)-containing fibronectin fragments to alpha5 beta1, suggesting that the binding site for RRETAWA is also closely overlapping with that for RGD. However, differences between the binding sites of RRETAWA and RGD were apparent in that (i) RGD peptides allosterically inhibited the binding of mAb 16 to alpha5 beta1, and (ii) several mAbs that perturbed binding of alpha5 beta1 to RGD had little effect on binding of alpha5 beta1 to RRETAWA. A double mutation in alpha5 (S156G/W157S) blocked the interaction of both RRETAWA and mAb 16 with alpha5 beta1 but had no effect on fibronectin binding or on the binding of other anti-alpha5 mAbs. Ser156-Trp157 is located near the apex of a putative loop region on the upper surface of a predicted beta-propeller structure formed by the NH2-terminal repeats of alpha5. Our findings suggest that this sequence forms part of the ligand-binding pocket of alpha5 beta1. Furthermore, as Ser156-Trp157 is unique to the alpha5 subunit, it may be responsible for the specific recognition of RRETAWA by alpha5 beta1.
Sự hội tụ của phương pháp biến thể nghiệm đàn hồi trong lý thuyết quá trình biến dạng đàn dẻo (1992)

None
Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo (2009)

Homologous recombination (HR), although an important DNA repair mechanism, is dangerous to the cell if improperly regulated. The Srs2 "anti-recombinase" restricts HR by disassembling the Rad51 nucleoprotein filament, an intermediate preceding the exchange of homologous DNA strands. Here, we cytologically characterize Srs2 function in vivo and describe a novel mechanism for regulating the initiation of HR. We find that Srs2 is recruited separately to replication and repair centers and identify the genetic requirements for recruitment. In the absence of Srs2 activity, Rad51 foci accumulate, and surprisingly, can form in the absence of Rad52 mediation. However, these Rad51 foci do not represent repair-proficient filaments, as determined by recombination assays. Antagonistic roles for Rad52 and Srs2 in Rad51 filament formation are also observed in vitro. Furthermore, we provide evidence that Srs2 removes Rad51 indiscriminately from DNA, while the Rad52 protein coordinates appropriate filament reformation. This constant breakdown and rebuilding of filaments may act as a stringent quality control mechanism during HR.
Anticoagulant and Antiprotease Profiles of a Novel Natural Heparinomimetic Mannopentaose Phosphate Sulfate (PI-88) (2001)

Heparinomimetic mannopentaose phosphate sulfate (PI-88) (Progen Industries Ltd. Brisbane, Australia), currently developed as an anticoagulant and antiproliferative agent, mainly is composed of a pentomannan. However, tetrasaccharide and disaccharide components are also present. The molecular profile and the anticoagulant potency of PI-88 are investigated in this study. Gel permeation chromatography and polyacrylamide gel electrophoresis analyses were carried out to determine the molecular profile and separation of components of PI-88, respectively. Potentiation of antithrombin III (ATIII) and heparin cofactor-II (HC-II) activity were measured using chromogenic substrate assay. In order to determine anticoagulant and antiprotease effects of PI-88, various global anticoagulant tests, such as the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), Hep-test (Haemachem Inc., St. Louis), ecarin clotting time (ECT), activated clotting time (ACT), and thromboelastography (TEG) were used. Anti-Xa and anti-IIa activities also were measured. The effect of PI-88 on the release of tissue factor pathway inhibitor (TFPI) was performed in nonhuman primates who received PI-88 and in endothelial cell culture systems. The relative susceptibility of PI-88 to heparinase I, protamine sulfate (PS), and platelet factor 4 (PF4) also was evaluated. The high-performance liquid chromatography profiles of PI-88 showed that its average molecular weight is approximately 2300 Da. Separation and gradient electrophoretic patterns of PI-88 showed that it is composed of five different fractions. This agent activates HC-II through inhibiting the thrombin generation but not inhibiting ATIII. Although PI-88 produced a concentration-dependent prolongation of all of the clotting tests, ECT gave the best correlation in the dose-response curve (ECT, r2 = 0.94; TT, r2 = 0.84; APTT, r2 = 0.69). Heparinomimetic mannopentaose phosphate sulfate (PI-88) exhibited marked inhibition of FIIa, but not of FXa. Heparinase I failed to produce significant neutralization of PI-88 in all the assays used, whereas PS and PF4 partially neutralized the effects of this compound. Heparinomimetic mannopentaose phosphate sulfate (PI-88) produced fivefold increase in the TFPI levels at 15 minutes after intravenous (IV) injection to primates. The incubation of PI-88 in endothelial cell culture system also showed a strong effect on TFPI release. These results suggest that PI-88 exhibited strong antithrombotic and anticoagulant activity in addition to its known antiproliferative properties. Because of the molecular characteristics and the dual nature of the pharmacologic action of PI-88, this agent represents an attractive pharmacologic agent for the control of thrombotic and proliferative disorders.
Numerical simulation of scatterer positions in a very dense medium with an application to the two‐dimensional Born approximation (1995)

Electromagnetic volume scattering theories for random media using a coherent field approach require some understanding of the statistical behavior of the locations of individual scatterers within the random medium. This knowledge manifests itself as the correlation function or pair distribution function, which is used to characterize the medium. This article presents a method for simulating the arrangements of particles of arbitrary shape within a very dense random medium, thus allowing for these functions to be calculated numerically. To demonstrate the significance of the Monte Carlo simulation, the problem of scattering from a two‐dimensional dense random medium is considered. Using a first‐order solution based on the Born approximation, it is shown that the approximate theoretically derived correlation function may lead to significant errors in the prediction of the backscatter response.
An Analytical, Temperature‐dependent Modelfor Majority‐ and Minority‐carrier Mobilityin Silicon Devices (1999)

A new analytical model for carrier mobility in silicon is presented, which is strongly oriented to CAD and suitable for implementation in device simulators. The effects of the electric field, temperature, and doping concentration are accounted for. In particular, the model unifies the descriptions of majority‐ and minority‐carrier mobility and includes the full temperature dependence. The effects of a high longitudinal field are included in the conventional velocity‐saturation form; the doping dependence is also incorporated in the latter. The model has been worked out starting from a preliminary investigation using a Boltzmann solver, and has been validated by a number of comparisons with published experiments on silicon.
Isolation of a fibronectin-binding protein from Staphylococcus aureus (1982)

Fibronectin ("cold-insoluble globulin") has been suggested to play a role in cell-to-cell and cell-to-substratum adhesions. The 70-kilodalton terminal part of human fibronectin has recently been shown to bind to Staphylococcus aureus. In the present study, a fibronectin-binding protein was purified from sonicated S. aureus strain E2371 by affinity chromatography on fibronectin-Sepharose. The fibronectin-binding protein was isolated from an extract of sonicated S. aureus containing at least 57 different proteins as determined by crossed immunoelectrophoresis in antibodies to sonicated S. aureus. The fibronectin-binding protein was released from fibronectin-Sepharose by carbamide (8 M). No impurities in the final preparation could be detected when tested in crossed immunoelectrophoresis. By polyacrylamide gel electrophoresis in both reduced and unreduced gels, the protein showed two bands with relative molecular masses of 197,000 and 60,000, respectively. A complex between the purified S. aureus protein and fibronectin could be demonstrated by crossed immunoelectrophoresis both in monospecific antibodies against fibronectin and in S. aureus polyspecific antibody.
Hidden Conditional Random Fields with Deep User Embeddings for Ad Targeting (2014)

Estimating a user's propensity to click on a display ad or purchase a particular item is a critical task in targeted advertising, a burgeoning online industry worth billions of dollars. Better and more accurate estimation methods result in improved online user experience, as only relevant and interesting ads are shown, and may also lead to large benefits for advertisers, as targeted users are more likely to click or make a purchase. In this paper we address this important problem, and propose an approach for improved estimation of ad click or conversion probability based on a sequence of user's online actions, modeled using Hidden Conditional Random Fields (HCRF) model. In addition, in order to address the sparsity issue at the input side of the HCRF model, we propose to learn distributed, low-dimensional representations of user actions through a directed skip-gram, a neural architecture suitable for sequential data. Experimental results on a real-world data set comprising thousands of user sessions collected at Yahoo servers clearly indicate the benefits and the potential of the proposed approach, which outperformed competing state-of-the-art algorithms and obtained significant improvements in terms of retrieval measures.
Genome and proteome of long-chain alkane degrading <i>Geobacillus thermodenitrificans</i> NG80-2 isolated from a deep-subsurface oil reservoir (2007)

The complete genome sequence of Geobacillus thermodenitrificans NG80-2, a thermophilic bacillus isolated from a deep oil reservoir in Northern China, consists of a 3,550,319-bp chromosome and a 57,693-bp plasmid. The genome reveals that NG80-2 is well equipped for adaptation into a wide variety of environmental niches, including oil reservoirs, by possessing genes for utilization of a broad range of energy sources, genes encoding various transporters for efficient nutrient uptake and detoxification, and genes for a flexible respiration system including an aerobic branch comprising five terminal oxidases and an anaerobic branch comprising a complete denitrification pathway for quick response to dissolved oxygen fluctuation. The identification of a nitrous oxide reductase gene has not been previously described in Gram-positive bacteria. The proteome further reveals the presence of a long-chain alkane degradation pathway; and the function of the key enzyme in the pathway, the long-chain alkane monooxygenase LadA, is confirmed by in vivo and in vitro experiments. The thermophilic soluble monomeric LadA is an ideal candidate for treatment of environmental oil pollutions and biosynthesis of complex molecules.