gebhart/patrepeval huggingface dataset:
Effects of exercise and passive head-up tilt on fractal and complexity properties of heart rate dynamics (2001)

tk;1Passive head-up tilt and exercise result in specific changes in the spectral characteristics of heart rate (HR) variability as a result of reduced vagal and enhanced sympathetic outflow. Recently analytic methods based on nonlinear system theory have been developed to characterize the nonlinear features in HR dynamics. This study was designed to assess the changes in the fractal and complexity measures of HR behavior during the passive head-up tilt and during exercise. Fractal exponent (alpha(1)) and approximate entropy (ApEn), measures of short-term correlation properties and overall complexity of HR, respectively, along with spectral components of HR variability were analyzed during a passive head-up tilt test (n = 10) and a low-intensity steady-state exercise (n = 20) in healthy subjects. We observed that alpha(1) increased during the tilt test (from 0.85 +/- 0.22 to 1.48 +/- 0.20; P < 0.001) and during the exercise (from 1.00 +/- 0.22 to 1.37 +/- 0. 14; P < 0.001). ApEn also increased during the exercise (from 1.04 +/- 0.11 to 1. 11 +/- 0.08; P < 0.05), but it did not change during the tilt test. The normalized high-frequency spectral component decreased and the low-frequency component increased similarly during both the exercise and the tilt test (P < 0.001 for all). Exercise and passive tilt result in an increase of short-term fractal correlation properties of HR dynamics, which is related to changes in the balance between the low- and high-frequency oscillations in controlled situations. Overall complexity of HR dynamics increases during exercise but not during passive tilt.
Characterization of colony-stimulating activity produced by human monocytes and phytohemagglutinin-stimulated lymphocytes (1977)

Human colony-stimulating activity (CSA) may support the proliferation of both human and murine granulocyte-macrophage progenitor cells (CFU-C) or, in the case of human urinary CSA, may only stimulate murine bone marrow CFU-C. CSA produced in the culture media of monocytes and macrophages and phytohemagglutinin-stimulated lymphocytes from human peripheral blood was characterized for both human and mouse marrow CFU-C stimulating activities. During the initial phase of a long-term cultures of monocytes, both human- and mouse-active CSA (MnCM-HM) were produced. In later phases of culture, however, only mouse-active CSA (MnCM-M) was produced. Fractionation on Sephadex G-150 revealed two functionally distinct species from MnCM-HM and lymphocytes conditioned medium, a high molecular weight factor (MW greater than 150,000) which stimulated mouse but not human colony formation, and a low molecular weight species (MW 25,000-35,000) which was active against both mouse and human target cells. However, MnCM-M revealed only one high molecular weight species (greater than 150,000), active only on mouse marrow. The possible biologic significance of such an activity is discussed.
Secure Biometric Templates from Fingerprint-Face Features (2007)

Since biometric data cannot be easily replaced or revoked, it is important that biometric templates used in biometric applications should be constructed and stored in a secure way, such that attackers would not be able to forge biometric data easily even when the templates are compromised. This is a challenging goal since biometric data are "noisy" by nature, and the matching algorithms are often complex, which make it difficult to apply traditional cryptographic techniques, especially when multiple modalities are considered. In this paper, we consider a "fusion " of a minutiae-based fingerprint authentication scheme and an SVD-based face authentication scheme, and show that by employing a recently proposed cryptographic primitive called "secure sketch ", and a known geometric transformation on minutiae, we can make it easier to combine different modalities, and at the same time make it computationally infeasible to forge an "original" combination of fingerprint and face image that passes the authentication. We evaluate the effectiveness of our scheme using real fingerprints and face images from publicly available sources.
Activation of flavin-containing oxidases underlies light-induced production of H <sub>2</sub> O <sub>2</sub> in mammalian cells (1999)

Violet-blue light is toxic to mammalian cells, and this toxicity has been linked with cellular production of H2O2. In this report, we show that violet-blue light, as well as UVA, stimulated H2O2 production in cultured mouse, monkey, and human cells. We found that H2O2 originated in peroxisomes and mitochondria, and it was enhanced in cells overexpressing flavin-containing oxidases. These results support the hypothesis that photoreduction of flavoproteins underlies light-induced production of H2O2 in cells. Because H2O2 and its metabolite, hydroxyl radicals, can cause cellular damage, these reactive oxygen species may contribute to pathologies associated with exposure to UVA, violet, and blue light. They may also contribute to phototoxicity often encountered during light microscopy. Because multiphoton excitation imaging with 1,047-nm wavelength prevented light-induced H2O2 production in cells, possibly by minimizing photoreduction of flavoproteins, this technique may be useful for decreasing phototoxicity during fluorescence microscopy.
Mesh construction from non-uniformly distributed and noisy 3D points recovered from image sequence (2002)

This paper describes a novel method for constructing triangle meshes from noisy and non-uniformly distributed 3D points. It consists of two steps: noise point removal uses a clustering algorithm and epipolar constraint method to identify and remove noise points from the 3D points; and a constructive polygonization algorithm interpolates cleaned 3D points to construct a triangle mesh of the object.
Single-Nanoparticle Tracking with Angstrom Localization Precision and Microsecond Time Resolution (2018)

Gold nanoparticles (AuNPs) have been used as a contrast agent for optical imaging of various single biomolecules. Because AuNPs have high scattering efficiency without photobleaching, biomolecular dynamics have been observed with nanometer localization precision and sub-millisecond time resolution. To understand the working principle of biomolecular motors in greater detail, further improvement of the localization precision and time resolution is necessary. Here, we investigated the lower limit of localization precision achievable with AuNPs and the fundamental law, which determines the localization precision. We first used objective-lens-type total internal reflection dark-field microscopy to obtain a scattering signal from an isolated AuNP. The localization precision was inversely proportional to the square root of the photon number, which is consistent with theoretical estimation. The lower limit of precision for a 40 nm AuNP was ∼0.3 nm with 1 ms time resolution and was restricted by detector saturation. To achieve higher localization precision, we designed and constructed an annular illumination total internal reflection dark-field microscopy system with an axicon lens, which can illuminate the AuNPs at high laser intensity without damaging the objective lens. In addition, we used high image magnification to avoid detector saturation. Consequently, we achieved 1.3 Å localization precision for 40 nm AuNPs and 1.9 Å localization precision for 30 nm AuNPs at 1 ms time resolution. Furthermore, even at 33 μs time resolution, localization precisions at 5.4 Å for 40 nm AuNPs and at 1.7 nm for 30 nm AuNPs were achieved. We then observed motion of head of kinesin-1 labeled with AuNP at microsecond time resolution. Transition cycles of bound/unbound states and tethered diffusion of unbound head during stepping motion on microtubule were clearly captured with higher time resolution or smaller AuNP than those used in previous studies, indicating applicability to single-molecule imaging of biomolecular motors.
A Burst-Mode Laser Diode Driver with Burst-by-Burst Power Saving for 10G-EPON Systems (2012)

A burst-mode laser diode driver for 10G-EPON with a burst-by-burst power-saving function reduces power consumption by 93% while the laser is turned off. A quick laser turn-on time of 15 ns is successfully achieved, including the power settling time. More than a 30% mask margin is obtained 50 ns after the laser turns on.
SIEVE: Scalable user grouping for large MU-MIMO systems (2015)

Multi-user multiple input and multiple output (MU-MIMO) is one predominate approach to improve the wireless capacity. However, since the aggregate capacity of MU-MIMO heavily depends on the channel correlations among the mobile users in a beamforming group, unwisely selecting beamforming groups may result in reduced overall capacity, instead of increasing it. How to select users into a beamforming group becomes the bottleneck of realizing the MU-MIMO gain. The fundamental challenge for user selection is the large searching space, and hence there exists a tradeoff between search complexity and achievable capacity. Previous works have proposed several low complexity heuristic algorithms, but they suffer a significant capacity loss. In this paper, we present a novel MU-MIMO MAC, called SIEVE. The core of SIEVE design is its scalable multi-user selection module that provides a knob to control the aggressiveness in searching the best beamforming group. SIEVE maintains a central database to track the channel and the coherence time for each mobile user, and largely avoids unnecessary computing with a progressive update strategy. Our evaluation, via both small-scale testbed experiments and large-scale trace-driven simulations, shows that SIEVE can achieve around 90% of the capacity compared to exhaustive search.
Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression. (1991)

Genetic diversity and relationships among 108 isolates of the bacterium Streptococcus pyogenes recently recovered from patients in the United States with toxic-shock-like syndrome or other invasive diseases were estimated by multilocus enzyme electrophoresis. Thirty-three electrophoretic types (ETs), representing distinctive multilocus clonal genotypes, were identified, but nearly half the disease episodes, including more than two-thirds of the cases of toxic-shock-like syndrome, were caused by strains of two related clones (ET 1 and ET 2). These two clones were also represented by recent pathogenic European isolates. A previous report of a relatively high frequency of expression of exotoxin A among isolates recovered from toxic-shock-like syndrome patients in the United States was confirmed; and the demonstration of this association both within clones and among distantly related clones supports the hypothesis that exotoxin A is a causal factor in pathogenesis of this disease. Near identity of the nucleotide sequences of the exotoxin A structural gene of six isolates of five ETs in diverse phylogenetic lineages was interpreted as evidence that the gene has been horizontally distributed among clones, presumably by bacteriophage-mediated transfer.
Retarding HCl Acid Reactivity Without Gelling Agents, Emulsifiers, or Polymers for Low to High Temperature Acidizing Applications (2020)

Abstract Placement of highly reactive stimulation fluid based on hydrochloric acid (HCl) into high temperature reservoirs or long pay intervals can be challenging and requires proper techniques to limit near-wellbore (NWB) spending, deconsolidation, and to extend the depth of fluid penetration. This is important when long laterals or interval characteristics limit injection rates away from the optimum, causing inefficient use of stimulation fluid. HCl acid, although readily accessible and widely used, can be highly problematic for far-field placement and stimulation. The addition of a low viscosity and nonpolymeric, fully water soluble surface modifying agent into 15 to 28% HCl acid formulations generates a fluid with a very distinct interaction on a carbonate-laden matrix, facilitating the control of premature spending in the NWB area. Core flow studies using Indiana limestone (IL) demonstrated that this surface-binding agent results in minimal core face erosion and spending, a minimization of pore volume to breakthrough (PVbt), and overall improved fluid efficiency. The fluid formulations tested and corresponding results confirm them to be effective over a broad range of temperature from 150 to 300°F, porosity from 8 to 20%, permeability from 0.2 to 800 mD, and flow regimes from 0.5 to 100 mL/min, thus highlighting the flexibility and ease of use. For all tests using the low viscosity HCl acid formulation, PVbt volumes were reduced in comparison to plain HCl acid, whereas the most notable volume reduction occurred when nonoptimal flow regimes were used. At flow rates of 1 mL/min, the formulated HCl acid fluid provides more than a five-fold PVbt reduction under similar conditions. More importantly, core face dissolution, characterized by computed tomography (CT) imaging, demonstrates that rock integrity is maintained even under extreme conditions, such as extremely low flow rate injection or temperature in excess of 300°F. On the contrary, even core flow tests performed at optimal flow rates provide a half-PVbt reduction when compared to plain HCl acid. The low viscosity HCl acid formulation has exhibited improved results across a breadth of downhole conditions that signify greater penetration and stimulation of carbonate reservoirs. Fluid compatibility with several necessary or expected HCl acid additives or stabilizers has been conducted and thoroughly tested, and such results indicate complete efficacy. Using the nonpolymeric surface agent in HCl acid fluid can provide a benefit in terms of equipment use and can facilitate stimulation treatments when pumping or completion limitations dictate low injection rates. Helping prevent inefficient and undesired spending allows the reactive fluid to penetrate deeper into the formation, accessing more reservoir area and providing larger drainage of the stimulated reservoir while helping prevent formation damage under high temperature or low injection rates.
Probiotics: a proactive approach to health. A symposium report (2015)

This report summarises talks given at the 8th International Yakult Symposium, held on 23-24 April 2015 in Berlin. Two presentations explored different aspects of probiotic intervention: the small intestine as a probiotic target and inclusion of probiotics into integrative approaches to gastroenterology. Probiotic recommendations in gastroenterology guidelines and current data on probiotic efficacy in paediatric patients were reviewed. Updates were given on probiotic and gut microbiota research in obesity and obesity-related diseases, the gut-brain axis and development of psychobiotics, and the protective effects of equol-producing strains for prostate cancer. Recent studies were presented on probiotic benefit for antibiotic-associated diarrhoea and people with HIV, as well as protection against the adverse effects of a short-term high-fat diet. Aspects of probiotic mechanisms of activity were discussed, including immunomodulatory mechanisms and metabolite effects, the anti-inflammatory properties of Faecalibacterium prausnitzii, the relationship between periodontitis, microbial production of butyrate in the oral cavity and ageing, and the pathogenic mechanisms of Campylobacter. Finally, an insight was given on a recent expert meeting, which re-examined the probiotic definition, advised on the appropriate use and scope of the term and outlined different probiotic categories and the prevalence of different mechanisms of activity.
Interactions of Recombinant and Wild-Type Baculoviruses with Classical Insecticides and Pyrethroid-Resistant Tobacco Budworm (Lepidoptera: Noctuidae) (1997)

In tests with neonate Heliothis virescens (F.), we characterized interactions of all combinations of a recombinant Autographa californica (Speyer) nuclear polyhedrosis virus (AcAaIT) that expresses an insect-selective neurotoxin (AaIT) and wild-type AcNPV when combined with low concentrations of several conventional insecticides. All combinations of the recombinant virus AcAaIT and insecticides showed a positive interaction (decrease in the median lethal time (LT50) compared with the LT50 for either component alone). A type II pyrethroid (cypermethrin, which modifies currents of sodium channels) and a carbamate (methomyl, an inhibitor of acetylcholinesterase) were synergistic in combination with AcAaIT. Other insecticides also showed a positive interaction when tested in combination with the recombinant virus, but joint activity was slightly antagonistic (i.e., less than predicted activity when combined) with wild-type AcNPV. We also characterized the effectiveness of AcAaIT against pyrethroid-resistant H. virescens larvae. Our results show that a resistant strain of H. virescens is more sensitive to the recombinant virus compared with a susceptible strain. Results of these studies should be useful in planning of future field trials to increase the effectiveness of nuclear polyhedrosis viruses and to manage resistance to pyrethroids and other insecticides.
Is new always better than old?  The development of human vaccines for anthrax (2009)

Anthrax is caused by a Gram-positive aerobic spore-forming bacillus called Bacillus anthracis. Although primarily a disease of animals, it can also infect man, sometimes with fatal consequences. As a result of concerns over the illicit use of this organism, considerable effort is focused on the development of therapies capable of conferring protection against anthrax. while effective concerns over the toxicity of the current vaccines have driven the development of second-generation products. Recombinant Protective Antigen (rPA), the nontoxic cell-binding component of anthrax lethal toxin, is the principal immunogen of the vaccines currently undergoing human clinical trials. While these new vaccines are likely to show reduced side effects they will still require multiple needle based dosing and the inclusion of the adjuvant alum which will make them expensive to administer and stockpile. To address these issues, researchers are seeking to develop vaccine formulations capable of stimulating rapid protection following needle-free injection which are stable at room temperature to facilitate stockpiling and mass vaccination programs. Recent concerns over the potential use of molecular biology to engineer vaccine resistant strains has prompted investigators to identify additional vaccine targets with which to extend the spectrum of protection conferred by rPA. While the injection of research dollars has seen a dramatic expansion of the anthrax vaccine field it is sobering to remember that work to develop the current second generation vaccines began around the time of the first gulf war. Almost two decades and millions of dollars later we still do not have a replacement vaccine and even when we do some argue that the spectrum of protection that it confers will not be as broad as the vaccine it replaces. If we are to respond effectively to emerging biological threats we need to develop processes that generate protective vaccines in a meaningful time frame and yield products in months not decades!
Improving the Quantum Yields of Semiconductor Quantum Dots through Photoenhancement Assisted by Reducing Agents (2009)

Surface modification of semiconductor quantum dots (QDs) often causes a drastic reduction of photoluminescence quantum yield (QY). Here, we report an efficient way to improve photoluminescence (PL) characteristics of silica-coated QDs using the combination of light-induced PL enhancement (photoenhancement) and the small molecule reducing agent, dithiothreitol (DTT). The photoenhancement process in the absence of a reducing agent is usually accompanied by a blue shift and broadening of the PL spectrum as well as a subsequent rapid PL quenching due to the competitive photo-oxidation process. The addition of DTT augments the degree of photoenhancement and inhibits the spectral shift and broadening. The photoenhancement assisted by DTT reported here should provide a simple and useful means of preparing stable, highly luminescent water-soluble silica-coated QDs that have PL QYs comparable to those exhibited by organic-soluble QDs.
Selegiline (deprenyl) treatment and death of nigral neurons in Parkinson's disease (1991)

We studied the effect of selegiline (deprenyl) treatment on the number of Lewy bodies and neuron counts in the substantia nigra in patients with Parkinson's disease (PD). The number of medial nigral neurons was greater and the number of Lewy bodies fewer in those PD patients who had been treated with selegiline in combination with levodopa as compared with patients who had received levodopa alone. This suggests that selegiline treatment may retard the death of nigral neurons, but alternative explanations, such as the reduction of levodopa dosage in selegiline-treated patients, are possible.
JMB (2012)

We present joint multi-user beamforming (JMB), a system that enables independent access points (APs) to beamform their signals, and communicate with their clients on the same channel as if they were one large MIMO transmitter. The key enabling technology behind JMB is a new low-overhead technique for synchronizing the phase of multiple transmitters in a distributed manner. The design allows a wireless LAN to scale its throughput by continually adding more APs on the same channel. JMB is implemented and tested with both software radio clients and off-the-shelf 802.11n cards, and evaluated in a dense congested deployment resembling a conference room. Results from a 10-AP software-radio testbed show a linear increase in network throughput with a median gain of 8.1 to 9.4x. Our results also demonstrate that JMB's joint multi-user beamforming can provide throughput gains with unmodified 802.11n cards.
Intelligent Media Forensics and Traffic Handling Scheme in 5G Edge Networks (2021)

The 5th generation (5G) communications evolved with heterogeneous user terminals and applications. A convergence of Mobile Edge Computing (MEC) and Software-Defined Networks (SDN) delivers gigantic challenges and opportunities for enhancing computing resources and user Quality of Service (QoS) in fronthaul and backhaul networks. Due to the precipitous expansion of user media in the 5G epoch, efficient media forensics methods are mandatory for specifying and offering effective safety handling based on individual application requirements. According to the exponential increment of Heterogeneous Internet of Things (HetIoT) devices, gigantic traffic will generate through bottleneck 5G fronthaul gateways. 5G fronthaul network environments consist of inadequate resources to surmount the enormous user traffic and communications, QoS will be reduced when the existence of traffic congestion occurs. To confront the aforementioned issues, this paper proposed intelligent media forensics and traffic handling scheme for controlling the Uplink (UL) transmission according to the Downlink (DL) statuses. Support Vector Machine (SVM) algorithm was applied to conduct the media forensics and MEC server integrated into fronthaul gateways, in which gateways resources are divided into UL and DL. Caching technology will be a part of 5G environments, and DL will be utilized for traffic caching. So, it is compulsory to adjust the communication traffic according to UL/DL resource utilization and control the forwarding traffic which relies on resource availability. The experiment was conducted by using computer software, and the proposed scheme illustrated a noteworthy outperformance over the conventional method in terms of diverse significant QoS factors including reliability, latency, and communication throughput.