gebhart/patrepeval huggingface dataset:
Adaptive pulse compression repair processing (2005)

It is well known that the standard matched filter used in radar pulse compression generates range sidelobes in the vicinity of large targets which can result in the masking of smaller nearby targets. Recently, pulse compression repair (PCR) was proposed as a means of suppressing the range sidelobes after matched filtering has taken place. This is especially applicable to in-service radar systems, where one may not have access to the received signal prior to standard pulse compression or where it may not be feasible to replace the current pulse-compression system. The PCR algorithm adaptively operates on the output of the standard matched filter, thereby treating the autocorrelation of the received waveform as if it were the transmitted waveform. This paper examines the effects of the Doppler mismatch on the PCR algorithm in which the resulting correlation between the transmitted waveform and the Doppler-shifted received waveform is mismatched to the waveform autocorrelation. It is shown that PCR degrades gracefully as Doppler mismatch increases, even in dense target scenarios.
Block placement with symmetry constraints based on the O-tree non-slicing representation (2000)

The ordered tree (O-tree) representation has recently gained much interest in layout design automation. Different from previous topological representations of non-slicing floorplans, the O-tree representation is simpler, needs linear computation effort to generate a corresponding layout, and exhibits a smaller upper-bound of possible configurations. This paper addresses the problem of handling symmetry constraints in the context of the O-tree representation. This problem arises in analog placement, where symmetry is often used to match layout-induced parasitics and to balance thermal couplings in differential circuits. The good performance of our placement tool dealing with several analog designs taken from industry proves the effectiveness of our technique.
Variational Analysis of GT Cut Quartz Crystal Resonators with the Supporting Portions at the Ends (1986)

It is well known that a GT cut quartz crystal resonator coupled between two extensional mode vibrations has a cubic curve in frequency-temperature characteristics as well as an AT cut quartz crystal resonator. This paper studies frequency-temperature characteristics and electrical characteristics of the GT cut quartz crystal resonator with the supporting portions at both ends of the vibrational portion.



First, a secular equation is derived from a vibration analysis of the resonator consisting of the vibrational portion and the supporting portions, by applying the energy method. From this secular equation, a relationship of resonant frequency, frequency temperature coefficients vs. a cut angle, a dimensional ratio and a mass ratio for the GT cut quartz crystal resonator is clarified theoretically. At the same time, from comparison of the calculated values with the experimental values, it is confirmed that they agree very well. Next, electrical characteristics of the quartz crystal resonators manufactured for trial experiments are measured. As a result, it is confirmed that a GT cut quartz crystal resonator with excellent frequency temperature characteristics, low crystal impedance and a high quality factor is realized.
Enantioselective Synthesis of α-Hydroxy Ketones via Benzaldehyde Lyase-Catalyzed C−C Bond Formation Reaction (2002)

(R)-Benzoins and (R)-2-hydroxypropiophenone derivatives are formed on a preparative scale by benzaldehyde lyase (BAL)-catalyzed C−C bond formation from aromatic aldehydes and acetaldehyde in aqueous buffer/DMSO solution with remarkable ease in high chemical yield and high optical purity. The substrate range of this thiamin diphosphate-dependent enzyme was examined with respect to a broad applicability of this benzoin condensation-type reaction in stereoselective synthesis.
Multilayered nuclear fuel element (1996)

A nuclear fuel element is described which is suitable for high temperature applications comprised of a kernel of fissile material overlaid with concentric layers of impervious graphite, vitreous carbon, pyrolytic carbon and metal carbide. The kernel of fissile material is surrounded by a layer of impervious graphite. The layer of impervious graphite is then surrounded by a layer of vitreous carbon. Finally, an outer shell which includes alternating layers of pyrolytic carbon and metal carbide surrounds the layer of vitreous carbon.
Stemphones, Novel Potentiators of Imipenem Activity Against Methicillin‐Resistant Staphylococcus aureus, Produced by Aspergillus sp. FKI‐2136. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mental fatigue measurement as application software on consumer devices (2015)

Monitoring mental fatigue is critical for traffic safety and health care. Various indexes of mental fatigue have been developed and used in the fields of ergonomics and industrial hygiene. One such index is the flicker-perception frequency threshold: the frequency at which the perception of flickering lights disappears for human observers. This index has a long history as a reliable indicator of mental fatigue in the laboratory setting. We have developed low-cost technologies for measuring mental fatigue objectively with widely available consumer devices such as personal computers and smartphones.
A Total Variation Approach for Customizing Imagery to Improve Visual Acuity (2015)

We describe a technique to generate imagery with improved sharpness for individuals having refractive vision problems. Our method can reduce their dependence on corrective eyewear. It also benefits individuals with normal vision by improving visual acuity at a distance and of small details. Our approach does not require custom hardware. Instead, the calculated images can be shown on a standard computer display, on printed paper, or superimposed on a physical scene using a projector. Our technique uses a constrained total variation method to produce a deconvolution result which, upon observation, appears sharp at the edges. We introduce a novel relative total variation term that enables controlling ringing reduction, contrast gain, and sharpness. The end result is the ability to generate sharper appearing images, even for individuals with refractive vision problems including myopia, hyperopia, presbyopia, and astigmatism. Our approach has been validated in simulation, in camera-screen experiments, and in a study with human observers.
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma (2018)

The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These molecular subgroups utilize distinct genetic mechanisms of telomere maintenance, either TERTp mutation leading to telomerase activation or ATRX-mutation leading to an alternative lengthening of telomeres phenotype (ALT). However, about 20% of glioblastomas lack alterations in TERTp and IDH. These tumors, designated TERTp<sup>WT</sup>-IDH<sup>WT</sup> glioblastomas, do not have well-established genetic biomarkers or defined mechanisms of telomere maintenance. Here we report the genetic landscape of TERTp<sup>WT</sup>-IDH<sup>WT</sup> glioblastoma and identify SMARCAL1 inactivating mutations as a novel genetic mechanism of ALT. Furthermore, we identify a novel mechanism of telomerase activation in glioblastomas that occurs via chromosomal rearrangements upstream of TERT. Collectively, our findings define novel molecular subgroups of glioblastoma, including a telomerase-positive subgroup driven by TERT-structural rearrangements (IDH<sup>WT</sup>-TERT<sup>SV</sup>), and an ALT-positive subgroup (IDH<sup>WT</sup>-ALT) with mutations in ATRX or SMARCAL1.
IBM Secure Enterprise Desktop (2014)

Using software-only approaches makes it is practically impossible to completely secure software applications, as well as corporate information, against determined cyber-criminals. Therefore, in an era where any general-purpose operating system (OS) with end-user access can be hacked, we propose using dedicated security hardware to ensure that only authorized people obtain access to sensitive information. The fundamental principle involves booting the end-user computer from such a trusted mobile device without trusting any software installed on the computer. The device establishes a secure connection to the back-end infrastructure to provide access to the user's OS, e.g., through a remote terminal access or provisioned on the local computer. The solution is very simple to operate, as many corporate employees are not necessarily IT (information technology) savvy. In this paper, we discuss the combination of our dedicated tamper-resistant security boot-token operating user credentials with known defense mechanisms, such as OS virtualization, trusted boot, establishment of client-side and server-side authenticated secure channels to trustworthy back-ends, and client-side storage encryption. This novel combination forms an easy-to-use and highly mobile security solution that addresses security challenges of the BYOD (bring-your-own-device) approach. As a proof point for the latter claims, we report on initial real-world usability tests.
Adaptive Tuning of Buffer Pool Size in Database Server Based on Iterative Algorithm (2007)

One of the system greatly affecting the performance of a database server is the size-division of buffer pools. This letter proposes an adaptive control method of the buffer pool sizes. This method obtains the nearly optimal division using only observed response times in a comparatively short duration.
Synthesis and biological evaluation of novel NK‐1 tachykinin receptor antagonists: The use of cycloalkyl amino acids as a template (1995)

In the course of a program aimed at synthesizing novel, potent NK-1 tachykinin receptor antagonists, we developed upon a bioactive model by comparing the low energy structures of a series of peptide and nonpeptide Substance P antagonists. The comparison was based on the superimposition of the aromatic rings, assuming that the rest of the molecule behaves predominantly as a template to arrange the key aromatic groups in the right spatial position. A series of 2-aminocyclohexane carboxylic acid analogues were then selected as the best templates for reproducing the postulated bioactive structure, leading to several pseudo-peptides with interesting biological activity. According to the molecular modeling, these compounds exhibit a neat parallel facing of the indolyl and naphthyl groups at about 3 A distance. Ultraviolet absorption and steady state fluorescence measurements support this conclusion, showing a linear correlation between the spectral properties and the binding affinity of these analogues. Stacking of the indole ring with naphthalene gives rise to a complex characterized by a well-defined molar extinction coefficient. Consistently, steady state and lifetime fluorescence measurements suggest that the quenching process is ascribable to ground-state interactions between the chromophores. Implications of the pi stacking propensity of aromatic groups in the biological activity of the compounds examined are briefly discussed.
An FBAR/CMOS Frequency/Phase Discriminator and Phase Noise Reduction System (2015)

A phase noise reduction scheme using a sensitive resonator-based low-noise phase-frequency discriminator is presented in this paper. The discriminator uses a high quality factor thin film bulk acoustic resonator in a notch filter configuration with common-mode traps to reduce the low-frequency noise up-conversion. The phase noise reduction scheme comprises of a main feedback loop to lock a voltage-controlled oscillator to the discriminator and another loop to adjust the depth of the notch. Two chips were fabricated in 0.13- μm CMOS technology integrating the discriminator and the phase noise reduction schemes, respectively. The 1.5-GHz discriminator shows phase noise floor of -128 dBc/Hz at 20 kHz, -142 dBc/Hz at 100 kHz, -162 dBc/Hz at 1 MHz, and -166 dBc/Hz at 4 MHz, while consuming 26 mW of power. The measured phase noise of the feedback reduction circuitry reaches the phase noise floor of the discriminator within the loop bandwidth, as expected.
Effect of an artificial neural network on radiologists' performance in the differential diagnosis of interstitial lung disease using chest radiographs. (1999)

An artificial neural network can provide a useful "second opinion" to assist radiologists in the differential diagnosis of interstitial lung disease using chest radiographs.
Natural Prevalence of Hepatitis C Virus Variants with Decreased Sensitivity to NS3·4A Protease Inhibitors in Treatment‐Naive Subjects (2008)

High levels of naturally occurring protease inhibitor-resistant variants were uncommon (<1% each) in HCV treatment-naive patients. TVR/PR efficiently inhibited V36M and R109K variants and contributed partial antiviral activity against the R155K variant. As new HCV agents are evaluated in clinical trials, it will be important to monitor the effect of baseline variants on sensitivity.
Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform (2017)

Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvanted protein have been able to induce high levels of concomitant humoral and cellular responses, complex manufacturing and handling in the field may limit their success. To combine the benefits of genetic and protein-based vaccination within one vaccine construct and to facilitate their use, we generated Human Adenovirus 35 (HAdV35) vectors genetically encoding a model antigen based on the Plasmodium falciparum (P. falciparum) circumsporozoite (CS) protein and displaying a truncated version of the same antigen (CSshort) via protein IX on the capsid, with or without a flexible glycine-linker and/or a 45Å-spacer. The four tested pIX-antigen display variants were efficiently incorporated and presented on the HAdV35 capsid irrespective of whether a transgene was encoded or not. Transgene-expression and producibility of the display-/expression vectors were not impeded by the pIX-display. In mice, the pIX-modified vectors induced strong humoral antigen-specific immunity that increased with the inclusion of the linker-/spacer molecules, exceeded the responses induced by the genetic, transgene-expressing HAdV35 vector, and surpassed recombinant protein in potency. In addition, the pIX- display/expression vectors elicited high antigen-specific cellular immune responses that matched those of the genetic HAdV35 vector expressing CS. pIX-modified display-/expression HAdV vectors may therefore be a valuable technology for the development of vaccines against complex pathogens, especially in resource-limited settings.
Expression, characterization, and serologic reactivity of recombinant surface antigen P22 of Toxoplasma gondii (1992)

The utility of recombinant Toxoplasma gondii surface antigen P22 for the detection of specific T. gondii antibodies in human sera was evaluated. Polymerase chain reaction was used to produce a 438-bp fragment of the P22 gene; the fragment corresponded to the amino acids predicted to be in the processed, native antigen. The fragment was subcloned into pGEX-2T and was expressed in Escherichia coli as a glutathione-S-transferase (GST) fusion protein. The fusion protein was purified in a soluble form and was found to be recognized by sera from infected individuals in immunoblots and an enzyme-linked immunosorbent assay. Immunoglobulin G antibodies in sera from 31 acutely infected patients in general reacted more strongly to the fusion protein than did those in sera from 31 patients with the chronic infection. None of the sera from a panel of 26 seronegative controls reacted with the fusion protein was separated from the GST partner by cleavage with thrombin, it retained its immunoreactivity and its electrophoretic mobility in polyacrylamide gels was found to be similar to that of native P22. By a modification of the published method for purification of the foreign polypeptide from the GST carrier, the recombinant P22 was readily purified to homogeneity by thrombin cleavage of the fusion protein while it was adsorbed to glutathione agarose.
The Multiple Forms of Starch‐Branching Enzyme I in <i>Solanum Tuberosum</i> (1996)

Western blot analysis showed the presence of three forms of starch-branching enzyme (SBE), with apparent molecular masses of 103, 97 and 80 kDa, in extracts of leaves and stored tubers of Solanum tuberosum. The 80-kDa form was absent in extracts of fresh tuber. Active 80-kDa enzyme was partially purified from stored tubers and sequence analysis showed that it, similar to the two larger enzyme forms, was an SBE-I isoform. Limited proteolysis of isolated 103-kDa SBE-I under native conditions removed approximately 200 amino acid residues from the carboxy terminus. A stable intermediate with an apparent molecular mass of approximately 80 kDa was formed. Since the 80-kDa form displayed full enzymatic activity and its circular-dichroism spectrum did not differ significantly from that of the 103-kDa enzyme, the carboxy-terminal portion of the enzyme was suggested to have an extended, unordered structure and therefore to be easily accessible to proteolysis. A cDNA sequence encoding a mature SBE-I was amplified from tuber mRNA of S. tuberosum by means of PCR. The 3' end of this sequence differed significantly from that of previously published data. PCR amplification and DNA sequencing of the 3' ends of the sbeI gene showed that four sbeI alleles exist in the cultivar studied. Two of these four alleles, sbeia and sbeIb, had slightly longer 3' ends compared with the other two, sbeIc and sbeId. The difference between the two groups of alleles was due to a partial deletion in sbeIc and sbeId of a segment duplicated in all alleles. All four alleles were expressed in leaf and tuber.
A Travelling-Wave Reasonator for Heating Low-Resistivity Silicon Ribbons and Wafers (1989)

AbstractA traveling-wave resonator and applicators for heating low-resistivity silicon ribbons and wafers have been studied. The performance of the microwave circuit agrees with the theoretical predictions. An applicator for 150 mm (six-inch) diameter wafers is described. Theoretical estimates of temperature distributions and some measured temperature distributions are included.Key Words: Process heatingJoule heatingMicrowave heatingSemiconductorTraveling wave resonator Additional informationNotes on contributorsM. SirkisMurray D. Sirkis and Changfu Hou are affiliated with the Department of Electrical and Computer Engineering and the Center for Solid-State Electronics Research, Arizona State University, Tempe, Arizona 85287–5706. C. Hou was a visiting scholar from Beijing Radio Measurement Institute, People’s Republic of China.C. HouMurray D. Sirkis and Changfu Hou are affiliated with the Department of Electrical and Computer Engineering and the Center for Solid-State Electronics Research, Arizona State University, Tempe, Arizona 85287–5706. C. Hou was a visiting scholar from Beijing Radio Measurement Institute, People’s Republic of China.
Planar fiber optic acoustic velocity sensor (1995)

The design and fabrication of a large area, planar fiber optic acoustic velocity sensor is reported. The device is based upon exploiting the optical fiber’s response to acceleration induced strains and by designing specific jackets which suppress the fiber sensor’s response to acoustic pressure. The broadband response to acceleration and the response to pseudostatic pressure changes were measured. These results confirm the efficacy of the concept and design.
Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation (2011)

African swine fever (ASF) is an acute haemorrhagic disease of domestic pigs for which there is currently no vaccine. We showed that experimental immunisation of pigs with the non-virulent OURT88/3 genotype I isolate from Portugal followed by the closely related virulent OURT88/1 genotype I isolate could confer protection against challenge with virulent isolates from Africa including the genotype I Benin 97/1 isolate and genotype X Uganda 1965 isolate. This immunisation strategy protected most pigs challenged with either Benin or Uganda from both disease and viraemia. Cross-protection was correlated with the ability of different ASFV isolates to stimulate immune lymphocytes from the OURT88/3 and OURT88/1 immunised pigs.
An overview of HYRISE - a Main Memory Hybrid Storage Engine. (2012)

HYRISE is a new relational storage engine for main memory database systems. It is built on the premise that enterprise application workloads can benefit from a dedicated main-memory storage engine. The key idea behind HYRISE is that it provides dynamic vertical partitioning of the tables it stores. Since enterprise applications typically use a large number of very wide tables, we designed a novel layout algorithm specifically tailored for enterprise data. Our algorithm uses a main memory cost model that is able to precisely estimate the physical access cost of database operators and to determine a vertical partitioning that yields the best execution performance. 1
A Receptor-Based Bioassay for Quantitative Detection of Gallium (1999)

The detection of gallium in biological samples is required due to its role in the diagnosis of tumor and for possible treatment of malignancies. However, the use of purely instrumental techniques is unsuitable for detection of low levels of gallium in biological matrixes. We have synthesized new protein conjugates based on 4-(2-pyridylazo) ligands. The conjugates were successfully employed for the detection of gallium in biological matrixes using a nonantibody-based sandwich assay format. The recovery level obtained was between 97 and 101.3 with a relative standard deviation of less than 5%. The assay resulted in a detection limit of 5 x 10(-8) M and a remarkable selectivity for gallium(III) relative to other metals investigated. The new method provided adequate accuracy for gallium applicable for animal physiology and clinical toxicology.
Compositional landscape for glass formation in metal alloys (2014)

A high-resolution compositional map of glass-forming ability (GFA) in the Ni-Cr-Nb-P-B system is experimentally determined along various compositional planes. GFA is shown to be a piecewise continuous function formed by intersecting compositional subsurfaces, each associated with a nucleation pathway for a specific crystalline phase. Within each subsurface, GFA varies exponentially with composition, wheres exponential cusps in GFA are observed when crossing from one crystallization pathway to another. The overall GFA is shown to peak at multiple exponential hypercusps that are interconnected by ridges. At these compositions, quenching from the high-temperature melt yields glassy rods with diameters exceeding 1 cm, whereas for compositions far from these cusps the critical rod diameter drops precipitously and levels off to 1 to 2 mm. The compositional landscape of GFA is shown to arise primarily from an interplay between the thermodynamics and kinetics of crystal nucleation, or more precisely, from a competition between driving force for crystallization and liquid fragility.
Polymer-metal front matching layers for ultrasonic transducers with arbitary impedance conversion (2010)

This paper presents a novel design principle for ultrasonic transducers, introducing multilayer polymer-metal structures which are well suited for impedance matching between high impedance piezoelectric ceramics and water or human tissue. It is shown that an inner polymer layer with an outer metal layer, when loaded by a low acoustic impedance propagation medium, acts as an efficient impedance converter.