gebhart/patrepeval huggingface dataset:
A Quantitative Metric for the Design of Selective Supercritical CO<sub>2</sub> Extraction of Lithium from Geothermal Brine (2019)

Abstract As demand grows for lithium, its recovery from geothermal brines provides an attractive alternative to slow mining. One promising extraction method uses crown ethers as extractants in supercritical carbon dioxide with cation exchangers to facilitate extraction from brine. Molecular dynamics modeling is used to understand the mechanism of binding between lithium (or sodium) and combinations of 14‐crown‐4 ethers and cation exchangers, and the predictive capability of computational modeling to test lithium selectivity is established for four combinations of crown ethers [methylene‐14‐crown‐4 (M14C4) and a fluorinated 14‐crown‐4 (F14C4)] and cation exchangers [di(2‐ethyl‐hexyl)phosphoric acid (HDEHP) and tetraethylammonium perfluoro‐1‐octanesulfonate (TPFOS)]. Binding free energies (given in kcal mol −1 ) of lithium and sodium, respectively, to crown ether–cation exchangers are 85 and 71 for M14C4–HDEHP, 90 and 71 for F14C4–HDEHP, 93 and 80 for M14C4–TPFOS, and 104 and 93 for F14C4–TPFOS. Good agreement is found between computational predictions and supercritical carbon dioxide extraction experiments at 60 °C and 250 bar. Binding free energy gives a suitable metric to describe extraction efficiency. Differences in the binding free energies of sodium and lithium to crown ethers determine the extraction selectivity. Fluorine groups are found to exert a positive influence to optimize extraction efficiency. Of the systems studied, F14C4 with TPFOS offers the most selective and efficient extraction system.
Registration of ‘CL153’ Rice (2016)

‘CL153’ (Reg. No. CV‐148, PI 677005), a Clearfield (BASF, Ludwigshafen, Germany) long‐grain rice ( Oryza sativa L.) cultivar, was developed by the Louisiana State University Agricultural Center at the H. Rouse Caffey Rice Research Station (RRS) near Crowley, LA, and approved for release by the Director of the Louisiana Agricultural Experiment Station in 2015. CL153 was derived from the cross 9502008‐A//AR‐1188/‘Cocodrie’/3/CFX26/9702128/4/‘Cheniere’ that was made in 2011 at the RRS and advanced in 2013 as an F 3 row selection based on agronomic characteristics. Testing in the Clearfield preliminary yield trials in 2013 indicated high yield potential and favorable agronomic characteristics. In 2013, 2014, and 2015, CL153 was evaluated in 23 replicated trials across six locations in Louisiana. Three high‐yielding, long‐grain, commercial cultivars, ‘CL111’, ‘CL151’, and ‘CL152’, were included as checks. Grain yield of CL153 was 9.1 t ha −1 compared with 8.5 t ha −1 for CL111, 9.4 t ha −1 for CL151, and 8.4 t ha −1 for CL152. Plant height for CL153 was 97 cm, which is equal to CL111 and CL151 and 2 cm shorter than CL152. CL153 reached 50% heading in 86 d, which was 4 d later than CL111, 1 d later that CL151, and 1 d earlier than CL152. The leaves, lemma, and palea of CL153 are glabrous, and the spikelet and apiculus are straw‐colored. CL153 is susceptible to sheath blight, moderately susceptible to bacterial panicle blight, Cercospora, and straighthead, and moderately resistant to blast.
Structures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl Conjugation (2012)

Bacterial β-lactamase enzymes are in large part responsible for the decreased ability of β-lactam antibiotics to combat infections. The inability to overcome β-lactamase mediated resistance spurred the development of inhibitors with penems and penam sulfones being amongst the most potent and broad spectrum mechanism-based inactivators. These inhibitors form covalent, "suicide-type" inhibitory intermediates that are attached to the catalytic S70 residue. To further probe the details of the mechanism of β-lactamase inhibition by these novel compounds, we determined the crystal structures of SHV-1 bound with penem 1, and penam sulfones SA1-204 and SA3-53. Comparison with each other and with previously determined crystal structures of members of these classes of inhibitors suggests that the final conformation of the covalent adduct can vary greatly amongst the complex structures. In contrast, a common theme of carbonyl conjugation as a mechanism to avoid deacylation emerges despite that the penem and penam sulfone inhibitors form different types of intermediates. The detailed insights gained from this study could be used to further improve new mechanism-based inhibitors of these common class A serine β-lactamases.
Phased-array antenna control using liquid crystals (1993)

A novel optical control system using nematic liquid crystals and acoustooptic devices is introduced that can provide compact, lightweight, low cost, transmit/receive mode, high performance (greater than 8 bits), truly analog, amplitude and phase control for large phased array antennas. The system provides independent amplitude and phase calibration and control capabilities across the array.
Effect of salt nutrients on mannitol production by Lactobacillus intermedius NRRL B-3693 (2006)

The effects of four salt nutrients (ammonium citrate, sodium phosphate, magnesium sulfate, and manganese sulfate) on the production of mannitol by Lactobacillus intermedius NRRL B-3693 in a simplified medium containing 300 g fructose, 5 g soy peptone, and 50 g corn steep liquor per liter in pH-controlled fermentation at 5.0 at 37 degrees C were evaluated using a fractional factorial design. Only manganese sulfate was found to be essential for mannitol production. Added manganese sulfate concentration of 0.033 g/l was found to support maximum production. The bacterium produced 200.6 +/- 0.2 g mannitol, 61.9 +/- 0.1 g lactic acid, and 40.4 +/- 0.3 g acetic acid from 300 g fructose per liter in 67 h.
Gonionenin: A New Cytotoxic Annonaceous Acetogenin from Goniothalamus giganteus and the Conversion of Mono-THF Acetogenins to Bis-THF Acetogenins (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGonionenin: A New Cytotoxic Annonaceous Acetogenin from Goniothalamus giganteus and the Conversion of Mono-THF Acetogenins to Bis-THF AcetogeninsZhe-ming Gu, Xin-ping Fang, Lu Zeng, Rong Song, Jocelyn H. Ng, Karl V. Wood, David L. Smith, and Jerry L. McLaughlinCite this: J. Org. Chem. 1994, 59, 12, 3472–3479Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/jo00091a043https://doi.org/10.1021/jo00091a043research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ultra-low bending loss of 0.007 dB/loop for 10 mm of bending diameter at 1550 nm in the double trenched bend insensitive optical fiber (2009)

The increase in the usage of FTTH in the optical communication has drawn much attention among the fiber optics engineers to face the challenges of sharp bends that are unavoidable at city apartment corners. In the current communication, we report experimental demonstration of the ultra-low bending loss in the single mode optical fiber. The optical fiber was fabricated using the modified chemical vapour deposition (MCVD) process. The optical fiber's core was surrounded by five cladding layers: innermost being the silica cladding followed by the first low-index trench, then the second silica cladding, the second low-index trench, and finally the third silica cladding. The double trenched bend insensitive optical fiber had the LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> cutoff wavelength at 1190 nm. Its mode field diameter was determined using the lateral splice loss measurement technique and it was found to be about 8.5-9.5 mum at 1550 nm.
An improved spectral load balancing method (1993)

We describe an algorithm for the static load balancing of scientific computations that generalizes and improves upon spectral bisection. Through a novel use of multiple eigenvectors, our new spectral algorithm can divide a computation into 4 or 8 pieces at once. This leads to balanced partitions that have lower communication overhead and are less expensive to compute than those of spectral bisection. In addition, our approach automatically works to minimize message contention on a hypercube or mesh architecture.
In vivo optical spectroscopy for improved detection of pancreatic adenocarcinoma: a feasibility study (2013)

Pancreatic adenocarcinoma has a five-year survival rate of less than 6%. This low survival rate is attributed to the lack of accurate detection methods, which limits diagnosis to late-stage disease. Here, an in vivo pilot study assesses the feasibility of optical spectroscopy to improve clinical detection of pancreatic adenocarcinoma. During surgery on 6 patients, we collected spectrally-resolved reflectance and fluorescence in vivo. Site-matched in vivo and ex vivo data agreed qualitatively and quantitatively. Quantified differences between adenocarcinoma and normal tissues in vivo were consistent with previous results from a large ex vivo data set. Thus, optical spectroscopy is a promising method for the improved diagnosis of pancreatic cancer in vivo.
Hyperproduction of Thermostable Lipase by Genetically Engineered Pseudomonas Species (1992)

One Pseudomonas species was isolated, and named KWI-56, which produced an extracellular thermostable lipase. More than 90% of the enzyme activity remained after 24 hours’ heat treatment at 60 °C [1].
Increase in the Biocompatibility of the Neutralized Chitosan Dermal Scaffold by Reconstruction of Wound Healing Microenvironment: In Vitro Study (2007)

The porous neutralized chitosan scaffold (NCS) was prepared by freeze-dry method. Its poor cell binding capacity was improved approximately five folds by mixing or coating of atelomeric type I collagen. In order to recreate wound-healing microenvironment within the NCS for the better wound healing effect, various concentrations of bFGF and fibronectin (FN) were supplied in the secondary freeze-dry process of the scaffold. NCS+ bFGF and NCS+FN improved the cell binding capacity by four folds and three folds respectively. Therefore supplementation of collagen, b-FGF and/or fibronectin in the NCS can improve the biocompatibility of the chitosanbased scaffold which itself revealed poor cell binding capacity.
Finite-Difference Modeling of Noise Coupling between Power/Ground Planes in Multilayered Packages and Boards (2006)

Multilayered packages and boards, such as high performance server boards, contain thousands of signal lines, which have to be routed on and through several layers with power/ground planes in between. There can be noise coupling not only in the transversal direction through the power/ground planes in such a structure, but also vertically from one plane pair to another through the apertures and via holes. In addition, the continuous increase in power demand along with reduced Vdd values results in significant current requirement for the future chips. Hence, the parasitic effects of the power distribution system become increasingly more critical regarding the signal integrity and electromagnetic interference properties of cost-effective high-performance designs. We present a multilayer finite-difference method (M-FDM), which is capable of characterizing such noise coupling mechanisms. This method allows considering realistic structures, which would be prohibitive to simulate using full-wave simulators.
Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing (2009)

We report a quantitative phase microscope based on spectral domain optical coherence tomography and line-field illumination. The line illumination allows self phase-referencing method to reject common-mode phase noise. The quantitative phase microscope also features a separate reference arm, permitting the use of high numerical aperture (NA > 1) microscope objectives for high resolution phase measurement at multiple points along the line of illumination. We demonstrate that the path-length sensitivity of the instrument can be as good as 41 pm/square root of Hz, which makes it suitable for nanometer scale study of cell motility. We present the detection of natural motions of cell surface and two-dimensional surface profiling of a HeLa cell.
Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH<sub>2</sub>-Terminal Kinase Inhibitors (2006)

C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK inhibitors could be valuable tools to study the therapeutic benefits of inhibiting these enzymes and as leads for potential drugs targeting JNKs. In this report, we disclose a series of potent and highly selective JNK inhibitors with good pharmacokinetic profiles.
Materials and fabrication processes for Nb-Si-Nb SNAP devices (1985)

Niobium-amourphous silicon-niobium SNAP junction fabrication has demonstrated great technological promise. An aluminum mask gives good resolution to the anodization process and can then be used to pattern an insulating layer self-aligned with the junctions. If the anodization is carried out using a constant-rate voltage ramp and the anodization current is plotted against the anodization voltage, one has an effective analytic tool for studying the niobium and determining an anodization endpoint. We incorporate thin palladium layers in our devices for three purposes. First, the layers provide for resistors while giving superconducting contact through the layer by the proximity effect. Second, the palladium acts as an etch-stop layer so that the top niobium layer can be plasma-etched without damage to the trilayer. A final palladium layer prevents oxidation and makes possible solder contacts to our devices.
The p53-dependent gamma-ray response of GADD45. (1994)

Activation of the human GADD45 gene by ionizing radiation (IR) has previously been shown to be dependent on the tumor suppressor and transcription factor p53 (M. B. Kastan, et al., Cell 71: 587-597, 1992). Unlike GADD45, the response of other DNA damage-inducible genes to IR is not dependent on p53 based on the observation that induction in a panel of cell lines did not correlate with a normal p53 status; this included human GADD153, another member of the gadd (growth arrest and DNA damage inducible) group; MyD118, a gene related to GADD45; and the protooncogenes c-jun and c-fos. This p53-dependent response of GADD45 was further investigated in human cells with halogenated pyrimidines, which act as radiosensitizers when incorporated into cellular DNA. When cellular DNA contained halogenated pyrimidines such as iododeoxyuridine (IdUrd), GADD45 gamma-ray induction, as measured by increased mRNA, was enhanced. Rapid induction could be seen with doses as low as 0.5 Gy, and substitution with IdUrd resulted in an approximately 2-fold increase in induction over a wide dose range. This level of IdUrd substitution produced a similar fold increase in cellular radiosensitivity and has been shown previously (T. M. Kinsella et al., Int. J. Radiation Oncology Biol. Phys. 13: 733-739, 1987) to produce a similar fold increase in DNA strand breaks after IR. Considering that substitution with halogenated pyrimidines would be expected to have little effect on other cellular targets after IR, these experiments indicate that actual damage to DNA, primarily strand breaks, is a major signal for the activation of this p53-dependent pathway that is required for GADD45 induction and for activation of the G1 "checkpoint" cell cycle delay.
Relational analysis and dictionaries (1989)

Abstract The aim of the paper is to propose adequate models for the description of and appropriate solutions to dictionary optimization. A dictionary dedicated to human users is (as with any human artefact) full of errors and inconsistencies which cannot be handled by a computer as an end user. Thus, it is necessary to check and optimize the contents. By using ‘pairwise optimal clustering’ approaches, similarity aggregation and the new quadri‐decomposition methods, we will show how they are adapted to handle linguistic data in different configurations (a dictionary of synonyms and a bilingual dictionary). On these real‐life applications (i.e. our processed dictionary of synonyms corresponds to more than 2.5 billion matrix cells) we will describe how different aspects of such a method can be a good tool for designing new dictionaries for both applications.
Performance Analysis of a Fuel Cell Hybrid Aviation Propulsion System (2012)

So-called Blended Wing Body (BWB)-type aircraft can accommodate electric fan driven propulsion systems as propulsion devices, providing distributed propulsion. Our earlier report presented a motor concept that is suitable for driving propulsion fans for that aircraft configuration. This report describes an analytical model of a propulsion system power source with size based on the reference vehicle design presented previously by the authors. Take-off and in-flight conditions are presented. The combined fuel-cell and gas-turbine system shows different features in each case.
Abstract 11156: Very High Engraftment, Proliferation, and Therapeutic Potential of IPSC-Derived Cardiomycytes (2014)

Human induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs) are one of the promising sources for cardiac cell therapy. Although several investigators reported the positive effect of the ...
A protocol design of communication state transfer for distributed computing (2002)

This paper presents the design of a communication state transfer protocol to support process migration in a dynamic, distributed computing environment. In our design, processes in distributed computation communicate one another via message passing and are migration-enabled. Due to mobility, mechanisms to maintain reliability and correctness of data communication are needed. Following an event-based approach, Such mechanisms are derived to handle various communication situations when a process migrates. These mechanisms collectively preserve the semantics of the communication and support efficient communication state transfer.
Advanced Augmented White Cane with obstacle height and distance feedback (2013)

The white cane is a widely used mobility aid that helps visually impaired people navigate the surroundings. While it reliably and intuitively extends the detection range of ground-level obstacles and drop-offs to about 1.2 m, it lacks the ability to detect trunk and head-level obstacles. Electronic Travel Aids (ETAs) have been proposed to overcome these limitations, but have found minimal adoption due to limitations such as low information content and low reliability thereof. Although existing ETAs extend the sensing range beyond that of the conventional white cane, most of them do not detect head-level obstacles and drop-offs, nor can they identify the vertical extent of obstacles. Furthermore, some ETAs work independent of the white cane, and thus reliable detection of surface textures and drop-offs is not provided. This paper introduces a novel ETA, the Advanced Augmented White Cane, which detects obstacles at four vertical levels and provides multi-sensory feedback. We evaluated the device in five blindfolded subjects through reaction time measurements following the detection of an obstacle, as well as through the reliability of dropoff detection. The results showed that our aid could help the user successfully detect an obstacle and identify its height, with an average reaction time of 410 msec. Drop-offs were reliably detected with an intraclass correlation > 0.95. This work is a first step towards a low-cost ETA to complement the functionality of the conventional white cane.
Parameter estimation based coherent multistatic processing (2009)

This paper develops the coherent generalized likelihood ratio test (GLRT) and the MVDR statistic for multistatic radar systems, conditioned on estimation of certain parameters that render the system coherent. Analytical and computer simulation results are presented to show substantially enhanced detection and geolocation of moving targets in clutter.
S-Nitrosoderivative of a Recombinant Fragment of von Willebrand Factor (S-Nitroso-AR545C) Inhibits Thrombus Formation in Guinea Pig Carotid Artery Thrombosis Model (2000)

Antiplatelet drugs are the mainstays of therapy for acute and chronic cardiovascular diseases. S-nitroso-AR545C - an S-nitrosoderivative of a recombinant von Willebrand factor fragment AR545C spanning Ala 444 to Asp 730 and containing an Arg 545 Cys mutation, was previously found to inhibit ristocetin- and ADP-induced platelet aggregation and the interaction of platelets with extracellular matrix (ECM). In the current study we tested the antithrombotic properties of S-nitroso-AR545C on guinea pig platelets and in a platelet-rich thrombosis model in the guinea pig. Preincubation of guinea pig platelets with 0.1 microM of S-nitroso-AR545C decreased ristocetin-induced agglutination by 40% (p = 0.009) and completely abolished ADP-induced aggregation (p <0.0001). At concentration of 1.0 microM, S-nitroso-AR545C completely inhibited platelet adhesion (represented by surface coverage - SC) and decreased aggregate formation (represented by average aggregate size - AS) by more than 50%. Treatment of guinea pigs with 1.0 mg/kg S-nitroso-AR545C resulted in a significantly delayed time to arterial occlusion (31.7+/-6.0 min vs. 13.9+/-3.2 min, p <0.02). Similarly, total patency time was longer in the group injected with S-nitroso-AR545C compared to the control group. However, the difference was not statistically significant (33.8+/-6.3 min vs. 20.2+/-3.3 min, p = 0.07). No change in platelet count, hematocrit and bleeding time was observed 60 min after injection compared to baseline. In contrast, a significant decrease in SC (p <0.0001) and AS (p <0.01) were observed 60 min after the injection of S-nitroso-AR545C, whereas no change in these parameters was observed in the control group. These observations indicate that S-nitroso-AR545C exhibits significant antiadhesive and antiaggregating effects in-vitro and inhibits clot formation in-vivo suggesting that this compound may have potential therapeutic advantages.