gebhart/patrepeval huggingface dataset:
Food elimination in IBS: the case for IgG testing remains doubtful. (2005)

I read with interest the study of a diet for irritable bowel syndrome (IBS) based on serum IgG levels to foods ( Gut 2004; 53 :1459–64).

In rigorous elimination diet studies, about one third of IBS patients are found not to have food intolerance.1–3 Yet it appears that everyone tested for food specific IgG in this study had some positive reactions and was therefore subjected to dietary recommendations. This does not in itself suggest that serum IgG is a particularly useful test.

One notable finding of this study appears to be that 87% of patients gave a high level of IgG to yeast. In two large scale studies of IBS using diagnostic elimination diets, the percentages who had a symptomatic reaction to yeast when challenged were 5.5% (out of 73 unselected IBS patients)1 and 12% (out of 122 unselected IBS patients).2 It seems unlikely that yeast causes IBS symptoms in 87% of patients in Manchester but in only 5–12% of patients in Oxfordshire and Cambridgeshire. A logical implication is that high levels of IgG against yeast do not, in themselves, reveal anything significant in relation to IBS symptoms.

The same, in my view, would follow for several other foods. The numbers of patients with positive responses to eggs, cow’s milk, and cashew nuts, as judged by IgG levels, are much higher than one would expect from empirical dietary studies,1,2 while the …
Genotypic characterization of<i>Staphylococcus aureus</i>isolated from bovines, humans, and food in Indonesia (2011)

The present study determined the genetic relationships between 41 Staphyloccocus (S.) aureus isolates from bovines, humans, and food using a single enzyme amplified fragment length polymorphism (AFLP) technique. We evaluated the prevalence of staphylococcal enterotoxin (SE) genes and other virulence gene determinants by PCR. The identification of S. aureus was based on culturing and biochemical tests, and by amplifying a specific section of the 23S rRNA gene. PCR amplification of the SE genes (sea, seb, sec, see, seg, seh, and sei) singly or in combination was observed. Most isolates of bovine origin harbored hla (84%) and cap5 (74%), while most isolates from humans harbored hla (73%), cap8 (91%), and fnbA (100%). Strains from food sources were positive for hla (100%), cap5 (100%), and cap8 (64%) unlike isolates from humans or bovines. A single enzyme AFLP analysis revealed a correlation between AFLP clusters of some strains and the source of the isolates The genotypic results of the present study might help to better understand the distribution of prevalent S. aureus clones among humans, bovines, and food and will help control S. aureus infections in Indonesia.
Large-scale Semantic Parsing without Question-Answer Pairs (2014)

In this paper we introduce a novel semantic parsing approach to query Freebase in natural language without requiring manual annotations or question-answer pairs. Our key insight is to represent natural language via semantic graphs whose topology shares many commonalities with Freebase. Given this representation, we conceptualize semantic parsing as a graph matching problem. Our model converts sentences to semantic graphs using CCG and subsequently grounds them to Freebase guided by denotations as a form of weak supervision. Evaluation experiments on a subset of the Free917 and WebQuestions benchmark datasets show our semantic parser improves over the state of the art.
Multi-Tiered On-Demand Resource Scheduling for VM-Based Data Center (2009)

The trend of using virtualization for server consolidation is more and more popular in enterprise data center. However, on-demand resource allocation among the concurrent hosted services in such a virtualized environment is still a challenge. In order to optimize resource allocation among services in data center, this paper proposes a multi-tiered resource scheduling scheme which automatically provides on-demand capacities to the hosted services via resources flowing among VMs. We model the resource flowing using optimization theory. Based on this model, we present a global re-source flowing algorithm in the multi-tiered resource scheduling scheme. This algorithm preferentially ensures performance of some critical services by degrading of others to some extent when resource competition arises. Using our RAINBOW prototype, we evaluate the multi-tiered resource scheduling scheme with the performance improvements for the most critical services up to 9%~16%, which are 75% of the maximum improvement margin, while performance degradation of others is up to 2%, and leads to 1%~5% improvements in resource utilization than RAINBOW without resource flowing. Compared with the existent scheme, our work leads to 9% less improvements for critical services, while introduces 39% less degradation to low priority services.
Detection of Porcine circovirus type 2 viremia and seroconversion in naturally infected pigs in a farrow-to-finish barn. (2006)

Porcine serum was assayed by 2 polymerase chain reaction (PCR) protocols (nested PCR [nPCR] and non-nested PCR) and a competitive enzyme-linked immunosorbent assay to determine when Porcine circovirus type 2 (PCV2) viremia and a rise in the serum level of PCV2-specific antibody occurred in pigs raised in a large Canadian farrow-to-finish barn. Eight serial blood samples were collected from each of 40 pigs from 5 to 156 (+/- 1.5) d of age; 6 pigs were removed from the study for various reasons at various times. Viremia was not detected in the samples collected before 72 d of age but was detected in those collected on or after 72 d: of 33 pigs, 7 (21%) had only 1 serum sample positive for PCV2 DNA by nPCR after day 72; 11 (33%) were intermittently positive by nPCR, non-nested PCR, or both between 72 and 156 d; and the remaining 15 (45%) were repeatedly positive (in 2 to 4 samples). The level of serum antibody against PCV2 declined after weaning and increased between 72 and 107 d of age, only after PCV2 was detected in serum. Our results show that PCV2 viremia persists in the presence of elevated levels of PCV2-specific antibody.
Electron Delocalization in Perylene Diimide Helicenes (2016)

We report two new helicenes derived from the double fusion of an acene with two perylene diimide (PDI) subunits. These PDI-helicene homologs exhibit very different structural and electronic properties, despite differing by only a single ring in the link between the PDI units. The shorter inter-PDI link brings the two PDI subunits closer together, and this results in the collision of their respective π-electron clouds. This collision facilitates intramolecular through-space electronic delocalization when the PDI-helicene is reduced.
Time-variant wavelet extraction with a local-attribute-based time-frequency decomposition for seismic inversion (2016)

Seismic impedance inversion has been widely used to estimate subsurface properties. Conventional inversion assumes that seismic data are the convolution result of seismic wavelet and reflectivity, implying that seismic data are stationary when a constant wavelet is considered. However, seismic data are nonstationary because of noise contamination and attenuation during wave propagation, which means that the frequency spectrum of the seismic signal changes from shallow to deep formations. We have developed a time-variant wavelet extraction method by using a local-attribute-based spectral decomposition technique. Time-variant wavelets are generated according to the local frequency spectrum, which can be used to construct a time-variant wavelet kernel matrix. By using this time-variant kernel matrix, we can obtain a better correlation between synthetic and extracted seismograms than by using constant wavelet on a field data example. Using this example, we have also compared the time-variant and constant wavelets for inverting the field data to estimate subsurface acoustic impedance. Our results showed improved resolution and a better fit to well-log-measured impedance by using the time-variant wavelets.
Production of Amino and Organic Acids from Protein Using Sub-Critical Water Technology (2013)

Abstract This work presents the hydrolysis of a water-soluble protein, bovine serum albumin (BSA), for the production of both amino and organic acids under the sub-critical water condition in the temperature range of 200–300°C. The products of the reaction were a water-insoluble solid phase, an aqueous phase, and an insignificant gas phase which was neglected in this study. Results have shown that BSA passes through an aggregation step, followed by a gel formation process which results in the formation of insoluble solid aggregates. Then, such formed solids unfolded with releasing polypeptides as an intermediate product then finally hydrolyzed to produce low molecular mass products such as amino and organic acids. It was found that there were insignificant amino acids produced in the temperature ranges of 200–225°C within 2 min and 275–300°C within 0.5 min. However, by extending the reaction time, the protein transferred to both amino and organic acids.
Dynamics of hyperphenylalaninemia and intellectual outcome in teenagers with phenylketonuria (2017)

Insufficient treatment adherence after early childhood is frequently observed in patients with phenylketonuria. Assessment of these individuals' long-term metabolic control could enable early detection of the risk of intellectual deterioration resulting from high blood phenylalanine concentration. However, the predictive value of specific parameters related to individual dynamics of hyperphenylalaninemia is not clear. Here, we assessed the impact of blood phenylalanine fluctuations during the first 12 years of life on cognitive outcome in early and continuously treated teenagers with phenylketonuria. We have analyzed a total of 5141 results of blood phenylalanine measurements in 32 patients. The phenylalanine levels of these patients were usually acceptable during their early childhood, but the control of hyperphenylalaninemia worsened and the average treatment adherence dropped to 40% during the late primary school. Our analysis revealed a strong association between the Wechsler intelligence verbal scores and the mean of the yearly means of phenylalanine concentrations (r=-0.62). The correlations of IQ scores with median phenylalanine concentrations and the variability of blood phenylalanine levels gave weaker associations. The Wechsler verbal scores were also strongly correlated with the treatment adherence level during preschool and late primary school (r=0.61 and 0.72). The mean of the yearly means of blood phenylalanine concentrations appears to be a better predictor of cognitive outcome in children with phenylketonuria than other parameters related to phenylalanine fluctuations. The percentage of acceptable phenylalanine levels below 50-60% should be regarded as a "red flag" due to the risk of intellectual deterioration in patients.
Magneto-Dendrite Effect: Copper Electrodeposition under High Magnetic Field (2017)

Ionic vacancy is a by-product in electrochemical reaction, composed of polarized free space of the order of 0.1 nm with a 1 s lifetime, and playing key roles in nano-electrochemical processes. However, its chemical nature has not yet been clarified. In copper electrodeposition under a high magnetic field of 15 T, using a new electrode system called cyclotron magnetohydrodynamic (MHD) electrode (CMHDE) composed of a pair of concentric cylindrical electrodes, we have found an extraordinary dendritic growth with a drastic positive potential shift from hydrogen-gas evolution potential. Dendritic deposition is characterized by the co-deposition of hydrogen molecule, but such a positive potential shift makes hydrogen-gas evolution impossible. However, in the high magnetic field, instead of flat deposit, remarkable dendritic growth emerged. By examining the chemical nature of ionic vacancy, it was concluded that ionic vacancy works on the dendrite formation with the extraordinary potential shift.
Creating a virtual slide map of sputum smears by auto-stitching (2011)

Under a microscope, only a small field of a slide can be seen through the eye piece. A digital replication of a large section of the smear on a slide is desirable for several applications, including image-based auto-positioning for automated microscopy and telepathology. To achieve this, images of the various fields on the slide can be captured and stitched automatically to form a virtual slide map. We compared two auto-stitching methods, namely the geometric hashing and the scale invariant feature transform (SIFT), applied to images of tuberculosis-infected sputum smears. Experimental results show good agreement between the two methods.
Improving the Growth of Newly Planted Apple Trees (1991)

Increasing the N application rate (in the form NH 4 NO 3 to newly planted `Marshall McIntosh'/M.9 apple (Malus domestica, Borkh.) trees beyond 76 g N per tree per year reduced growth in the first two growing seasons. Peat moss or composted manure mixed into the planting hole of `Royal Gala'/M.26 increased growth in the first growing season after planting. The soil-active fungicides, fosetyl-Al and metalaxyl, increased trunk and shoot growth of `Royal Gala'/M.26 in the first season after planting. Mulching enhanced growth of `Gala'/M.26 only in the third season after planting, a season during which the region experienced a drought. Mulching significantly increased bloom on `Gala'/M.26 2 years after planting. The growth of `Royal Gala'/M.26, `Marshall McIntosh'/M.26, and `Ace Delicious'/M.26 was not affected by planting technique planting by hand in 61-cm augered holes vs. planting with a mechanical tree planter. Chemical names used N-(2,6-dimethyl-phenyl)-N-(methloxyacetyl)alanine methyl ester (metalaxyl); aluminum tris (O-ethyl phosphonate) (fosetyl-Al); 1,1'-dimethyl-4-4'-bipyridinium ion (paraquat); isopropylamine salt of N-(phosphonomethyl) glycine (glyphosate).
Immobilization of Cell-Adhesive Laminin Peptides in Degradable PEGDA Hydrogels Influences Endothelial Cell Tubulogenesis (2013)

Attachment, spreading, and organization of endothelial cells into tubule networks are mediated by interactions between cells in the extracellular microenvironment. Laminins are key extracellular matrix components and regulators of cell adhesion, migration, and proliferation. In this study, laminin-derived peptides were conjugated to poly(ethylene glycol) (PEG) monoacrylate and covalently incorporated into degradable PEG diacrylate (PEGDA) hydrogels to investigate the influence of these peptides on endothelial cellular adhesion and function in organizing into tubule networks. Degradable PEGDA hydrogels were synthesized by incorporating a matrix metalloproteinase (MMP)-sensitive peptide, GGGPQGIWGQGK (abbreviated PQ), into the polymer backbone. The secretion of MMP-2 and MMP-9 by endothelial cells promotes polymer degradation and consequently cell migration. We demonstrate the formation of extensive networks of tubule-like structures by encapsulated human umbilical vein endothelial cells in hydrogels with immobilized synthetic peptides. The resulting structures were stabilized by pericyte precursor cells (10T1/2s) in vitro. During tubule formation and stabilization, extracellular matrix proteins such as collagen IV and laminin were deposited. Tubules formed in the matrix of metalloproteinase sensitive hydrogels were visualized from 7 days to 4 weeks in response to different combination of peptides. Moreover, hydrogels functionalized with laminin peptides and transplanted in a mouse cornea supported the ingrowth and attachment of endothelial cells to the hydrogel during angiogenesis. Results of this study illustrate the use of laminin-derived peptides as potential candidates for modification of biomaterials to support angiogenesis.
Potential of Insects as Food and Feed in Assuring Food Security (2012)

With a growing world population and increasingly demanding consumers, the production of sufficient protein from livestock, poultry, and fish represents a serious challenge for the future. Approximately 1,900 insect species are eaten worldwide, mainly in developing countries. They constitute quality food and feed, have high feed conversion ratios, and emit low levels of greenhouse gases. Some insect species can be grown on organic side streams, reducing environmental contamination and transforming waste into high-protein feed that can replace increasingly more expensive compound feed ingredients, such as fish meal. This requires the development of cost-effective, automated mass-rearing facilities that provide a reliable, stable, and safe product. In the tropics, sustainable harvesting needs to be assured and rearing practices promoted, and in general, the food resource needs to be revalorized. In the Western world, consumer acceptability will relate to pricing, perceived environmental benefits, and the development of tasty insect-derived protein products.
Quantitative structure-activity relationship of molecules constituent of different essential oils with antimycobacterial activity against Mycobacterium tuberculosis and Mycobacterium bovis (2015)

The description of the molecular properties and the structural characteristics responsible for antimycobacterial activity of the compounds tested, were used for the development of mathematical models that describe structure-activity relationship. The identification of molecular and structural descriptors provide insight into the mechanisms of action of the active molecules, and all this information can be used for the design of new structures that could be synthetized as potential new antimycobacterial agents.
Application of Sr<sub>2</sub>Nb<sub>2</sub>O<sub>7</sub> Family Ferroelectric Films for Ferroelectric Memory Field Effect Transistor (1998)

The compounds of the Sr 2 Nb 2 O 7 (SNO) family are suitable for use as ferroelectric materials for ferroelectric memory field effect transistors (FETs), because these substances have a low dielectric constant, low coercive field and high heat-resistance. In this study, we succeeded in preparing Sr 2 (Ta,Nb) 2 O 7 (STN) capacitors on polycrystalline silicon (poly-Si). From SIMS profiles, no interdiffusion in the STN metal ferroelectric metal insulator semiconductor (MFMIS) structure was confirmed. C – V and I D – V G hysteresis curves which were dependent on ferroelectric polarization were obtained. These capacitors were applied to floating gate type ferroelectric random access memory (FFRAM) cells. The degradation in ferroelectricity of STN capacitors was not observed during FFRAM cell fabrication process. We succeeded in operating FFRAM cells with a lower voltage than that required for PZT and confirmed the drain current difference of 1 or 2 orders at the 30 s after applying write pulses of ±5 V or ±10 V.
Esterification of carboxylic acids with trialkyloxonium salts (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEsterification of carboxylic acids with trialkyloxonium saltsDouglas J. Raber, Patrick Gariano Jr., Albert O. Brod, Anne Gariano, Wayne C. Guida, Anne R. Guida, and Mark D. HerbstCite this: J. Org. Chem. 1979, 44, 7, 1149–1154Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://doi.org/10.1021/jo01321a027RIGHTS & PERMISSIONSArticle Views1867Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (779 KB) Get e-Alertsclose Get e-Alerts
Cooling Heads and Hearts Versus Cooling Our Heels (2010)

E vidence suggests that full implementation of therapeutic hypothermia after cardiac arrest could save thousands of lives each year. Critical unanswered questions persist, beginning with a lack of evidence in regard to how early cooling should be initiated, which cooling strategy is most effective at cooling the brain, and, ultimately, what method of cooling is most optimal for survival. Two reports in this issue of Circulation, from Castren et al 1 and Bernard et al, 2 begin to provide some of these needed data. Given the immense logistic difficulty of performing randomized field studies, the teams of investigators involved in both studies are to be congratulated for conducting this important research. The presented results begin to explore the important question of how quickly and by what methods cooling should be started in the field. Although they provide some answers, they also provoke new questions. For clinicians using therapeutic hypothermia with cardiac arrest patients, it is important to clearly understand the pros and cons of earlier cooling initiated in the field with the newer techniques explored in these 2 reports. It is also important to understand the differences between the findings in these studies, along with the practical implications and limitations of each technique, before conclusions are drawn about the manner in which these studies may influence practice.
Spatial GNSS Spoofing Against Drone Swarms With Multiple Antennas and Wiener Filter (2020)

Spoofing of global-navigation satellite system (GNSS) signals to induce a target position estimate is a relevant security threat to the navigation of drones. However, spoofing multiple drones simultaneously as they move in a swarm, without disrupting their formation, is a complex task. In this paper, we propose to transmit spoofing signals from the ground, such that the fake position can be estimated in any point of an area of the plane where the swarm is moving. To this end we filter the satellite-generated GNSS signals with a multidimensional linear filter, and transmit the filtered signal with multiple ground antennas. The multidimensional filter is designed according to a generalized Wiener-filter criterion, such that the fake signal is accurately reproduced (in terms of mean squared error (MSE)) in the whole spoofed area. We investigate the impact of various design parameters (among others, the size of the spoofed area, the number of ground antennas, and the number of spoofed satellites) on both the MSE, and the probability of acquisition of the spoofed signal by the drones.
Detectability: A new criterion for evaluation of the confocal microscope (1993)

Abstract We introduce a new criterion to explore the performance, with respect to signal‐noise ratio for fluorescent imaging, in the confocal microscope. This criterion, which we term detectability, has three forms: transverse, axial, and three‐dimensional. It describes the ease with which a small object can be detected in transverse images, axial images, and three‐dimensional images.