gebhart/patrepeval huggingface dataset:
Instant 3D Object Tracking with Applications in Augmented Reality (2020)

Tracking object poses in 3D is a crucial building block for Augmented Reality applications. We propose an instant motion tracking system that tracks an object's pose in space (represented by its 3D bounding box) in real-time on mobile devices. Our system does not require any prior sensory calibration or initialization to function. We employ a deep neural network to detect objects and estimate their initial 3D pose. Then the estimated pose is tracked using a robust planar tracker. Our tracker is capable of performing relative-scale 9-DoF tracking in real-time on mobile devices. By combining use of CPU and GPU efficiently, we achieve 26-FPS+ performance on mobile devices.
A global self-localization technique utilizing local anomalies of the ambient magnetic field (2009)

Magnetic field fluctuations in modern buildings arise from both natural and man-made sources, such as steel and reinforced concrete structures, electric power systems, electric and electronic appliances, and industrial devices. If the anomalies of the magnetic field inside the building are nearly static and they have sufficient local variability, they provide a unique magnetic fingerprint that can be utilized in global self-localization. In this article, a Monte Carlo localization (MCL) technique based on this hypothesis is proposed. The feasibility of the technique is demonstrated by presenting a series of global localization experiments conducted in four arbitrarily selected buildings, including a hospital. The experiment setup consists of a mobile robot instrumented with a 3-axis magnetometer and a computer. In addition, successful human self-localization experiments were conducted by using a wireless wearable magnetometer. The reported experiments suggest that the ambient magnetic field may remain sufficiently stable for longer periods of time, giving support for self-localization techniques utilizing the local deviations of the field.
Insight into the Physiological Function(s) of Uteroglobin by Gene‐Knockout and Antisense‐Transgenic Approaches (2000)

To determine the physiological function(s) of uteroglobin (UG), a steroid-inducible, homodimeric, secreted protein, we have generated transgenic mice that either are completely UG-deficient due to UG gene-knockout (UG-KO) or are partially UG-deficient due to the expression of UG antisense RNA (UG-AS). Both the UG-KO and UG-AS mice develop immunoglobulin A (IgA) nephropathy (IgAN), characterized by microhematuria, albuminuria, and renal glomerular deposition of IgA, fibronectin (Fn), collagen, and C3 complement. This phenotype of both UG-KO and UG-AS mice is virtually identical to that of human IgAN, the most common primary glomerulopathy worldwide. The molecular mechanism by which UG prevents this disease in mice appears to center around UG's interaction with Fn. Since Fn, IgA, and UG are present in circulation and high plasma levels of IgA-Fn complex have been reported in human IgAN, we sought to determine whether UG interacts with Fn and prevents Fn-Fn and/or IgA-Fn interactions, essential for abnormal tissue deposition of Fn and IgA. Our coimmunoprecipitation studies uncovered the formation of Fn-UG heteromers in vitro and these heteromers are detectable in the plasma of normal mice, but not UG-KO mice. Further, high plasma levels of IgA-Fn complex, a characteristic of human IgAN patients, were also found in UG-KO mice. Finally, coadministration of UG + Fn or UG + IgA to UG-KO mice prevented glomerular deposition of Fn and IgA, respectively. Our results define a possible molecular mechanism of IgAN and provide insight into at least one important physiological function of UG in maintaining normal renal function in mice.
Novel monoclonal antibodies for measuring 5-fluorouracil concentrations in biological fluids (2006)

2055 Background: Therapeutic drug monitoring of anticancer drugs has potential for improving treatment of individual patients. 5-Fluorouracil (5-FU) has been reported to exhibit high pharmacokinetic variability and in some cases severe toxicity. Pharmacokinetic guided dosing of 5-FU using physical methodologies has demonstrated clinical usefulness in decreasing toxicity while resulting in equivalent or improved outcomes. The current physical methods for measuring 5-FU require specially trained personnel, are expensive, time consuming and therefore not amenable for widespread use. However, an automated immunoassay would provide a rapid, simple and inexpensive method to routinely measure levels of 5-FU in patients. Methods: In order to develop monoclonal antibodies that were selective for 5-FU, immunogens were prepared by attaching the drug to keyhole limpet hemocyanin (KLH) or bovine thyroglobulin (BTG) via a hydrocarbon tether bound through the N-3 nitrogen. Mice were immunized and the resulting antibodies were screened by ELISA. The selection of antibodies was based on sensitivity and cross-reactivity characteristics. Results: These immunogens were successful in eliciting 20 highly selective monoclonal antibodies for 5-FU with immunoassay dose response curves in the clinical range of 10 ng/mL to 5000 ng/mL. The immunoassay was tested with a mixture of the various pyrimidine compounds at their respective endogenous levels and shown to have no impact on the measurement of 5-FU. The Table below lists typical cross-reactivity performance characteristics that are elicited by this type of immunogen. Conclusion: This library of monoclonal antibodies represents the first report of antibodies selective for 5-fluorouracil. These antibodies will be useful for the rapid and cost effective analysis of 5-FU in human samples, providing a tool for optimization of 5-FU levels by pharmacokinetic guided dosing. [Table: see text] [Table: see text]
Clinical Validation of a Proteomic Biomarker Threshold for Increased Risk of Spontaneous Preterm Birth and Associated Clinical Outcomes: A Replication Study (2021)

Preterm births are the leading cause of neonatal death in the United States. Previously, a spontaneous preterm birth (sPTB) predictor based on the ratio of two proteins, IBP4/SHBG, was validated as a predictor of sPTB in the Proteomic Assessment of Preterm Risk (PAPR) study. In particular, a proteomic biomarker threshold of -1.37, corresponding to a ~two-fold increase or ~15% risk of sPTB, significantly stratified earlier deliveries. Guidelines for molecular tests advise replication in a second independent study. Here we tested whether the significant association between proteomic biomarker scores above the threshold and sPTB, and associated adverse outcomes, was replicated in a second independent study, the Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor (TREETOP). The threshold significantly stratified subjects in PAPR and TREETOP for sPTB (<i>p</i> = 0.041, <i>p</i> = 0.041, respectively). Application of the threshold in a Kaplan-Meier analysis demonstrated significant stratification in each study, respectively, for gestational age at birth (<i>p</i> < 001, <i>p</i> = 0.0016) and rate of hospital discharge for both neonate (<i>p</i> < 0.001, <i>p</i> = 0.005) and mother (<i>p</i> < 0.001, <i>p</i> < 0.001). Above the threshold, severe neonatal morbidity/mortality and mortality alone were 2.2 (<i>p</i> = 0.0083,) and 7.4-fold higher (<i>p</i> = 0.018), respectively, in both studies combined. Thus, higher predictor scores were associated with multiple adverse pregnancy outcomes.
History of the flextensional electroacoustic transducer (1990)

The flextensional electroacoustic transducer is resurging as a candidate for high-power, low-frequency active sonar. It has experienced steady investigation and development since the late 1950s and is popular enough now so that it is even advertised in naval and ocean-related publications. Despite this popularity, the history of its invention and development has remained cloudy. The invention is usually credited to William J. Toulis during the late 1950s. However, at least two flextensional designs were invented, developed, and constructed during 1929–1936 by a pioneer in underwater acoustics, Harvey C. Hayes, at the U. S. Naval Research Laboratories in Washington, DC. These flextensionals were intended as aeroacoustic foghorn sources. The Hayes flextensionals then vanished from development during the mid-1930s, and the concept was not revisited (in the U.S.) until the mid-to-late 1950s by Toulis and Frank R. Abbott at the U. S. Naval Electronics Laboratory, San Diego, CA. This paper will review the history of the flextensional transducer beginning with Hayes’ work, review the classes of flextensional transducers, and discuss modern flextensional transducers.
Circadian Neuroendocrine Role in Age-Related Changes in Body Fat Stores and Insulin Sensitivity of the Male Sprague-Dawley Rat (1993)

A role for circadian neuroendocrine rhythms in the age-related development of obesity and insulin resistance was investigated in the male Sprague-Dawley rat. The phases and amplitudes of the plasma rhythms of several metabolic hormones (i.e. corticosterone, prolactin, insulin, and triiodothyronine) differed in lean, insulin-sensitive (3-week-old rats). insulin-resistant (8-week-old rats) and obese, insulin-resistant (44-week-old rats) animals. Simulation of the daily rhythms of endogenous corticosterone and prolactin by daily injections of the hormones at times corresponding to the peak levels found in 3-week-old rats reversed age-related increases in insulin resistance and body fat in older (5-6-month-old) rats. Ten such daily injections of corticosterone and prolactin in 12-14-week-old rats produced long-term reductions in body fat stores (30%). plasma insulin concentration (40%″). and insulin resistance (60%) (determined by a glucose tolerance test) measured 11-14 weeks after the treatment. Alterations in circadian neuroendocrine rhythms may account for age-related changes in carbohydrate and lipid metabolism in the male Sprague-Dawley rat, and resetting of these rhythms by appropriately timed daily injections of corticosterone and prolactin may help maintain metabolism characteristic of younger animals.
Thymosin β <sub>4</sub> stimulates directional migration of human umbilical vein endothelial cells (1997)

Thymosin beta 4 (T beta 4) is a 4.9 kDa polypeptide that interacts with G-actin and is thought to be an important mediator in cell proliferation, migration, and differentiation. T beta 4 has been identified as a factor involved in the differentiation of human umbilical vein endothelial cells (HUVECs) cultured on Matrigel. Here we have used various in vitro and in vivo migration assays to demonstrate the role of T beta 4 in endothelial cell migration. Our results demonstrate that T beta 4 acts as a chemoattractant for endothelial cells, stimulating the migration of HUVECs in Boyden chambers four- to sixfold over that observed with media alone. Of the primary cell types tested, only human coronary artery cells responded to T beta 4 treatment, suggesting that the migration activity of T beta 4 was endothelial cell-specific. T beta 4 significantly accelerated the rate of migration into the scratch wounded area of a HUVEC monolayer. T beta 4 treatment also increased the production of matrix metalloproteinases that may degrade the basement membrane during angiogenesis. Additional experiments using subcutaneously implanted Matrigel showed that T beta 4 stimulated cell migration in vivo. These results provide the first direct evidence that T beta 4 has chemoattractive activity and promotes angiogenesis by stimulating the migration of endothelial cells.
Network Science Based Quantification of Resilience Demonstrated on the Indian Railways Network (2015)

The structure, interdependence, and fragility of systems ranging from power-grids and transportation to ecology, climate, biology and even human communities and the Internet have been examined through network science. While response to perturbations has been quantified, recovery strategies for perturbed networks have usually been either discussed conceptually or through anecdotal case studies. Here we develop a network science based quantitative framework for measuring, comparing and interpreting hazard responses as well as recovery strategies. The framework, motivated by the recently proposed temporal resilience paradigm, is demonstrated with the Indian Railways Network. Simulations inspired by the 2004 Indian Ocean Tsunami and the 2012 North Indian blackout as well as a cyber-physical attack scenario illustrate hazard responses and effectiveness of proposed recovery strategies. Multiple metrics are used to generate various recovery strategies, which are simply sequences in which system components should be recovered after a disruption. Quantitative evaluation of these strategies suggests that faster and more efficient recovery is possible through network centrality measures. Optimal recovery strategies may be different per hazard, per community within a network, and for different measures of partial recovery. In addition, topological characterization provides a means for interpreting the comparative performance of proposed recovery strategies. The methods can be directly extended to other Large-Scale Critical Lifeline Infrastructure Networks including transportation, water, energy and communications systems that are threatened by natural or human-induced hazards, including cascading failures. Furthermore, the quantitative framework developed here can generalize across natural, engineered and human systems, offering an actionable and generalizable approach for emergency management in particular as well as for network resilience in general.
Three-terminal semiconductor junction thermoelectric devices: improving performance (2013)

A three-terminal thermoelectric device based on a p–i–n semiconductor junction is proposed, where the intrinsic region is mounted onto what is typically a bosonic thermal terminal. Remarkably, the figure of merit of the deviceis governed also by the energy distribution of the bosons participating in the transport processes, in addition to the electronic. An enhanced figure of merit can be obtained when the relevant distribution is narrow and the electron–boson coupling is strong (such as for optical phonons). We study the conditions for which the figure of merit of the three-terminal junction can be greater than those of the usual thermoelectrical devices made of the same material. A possible setup with a high figure of merit, based on Bi _2 Te _3 /Si superlattices, is proposed.
Modeling and analyzing non-seizure EEG data for patients with epilepsy (1996)

We present nonlinear analysis of non-seizure electroencephalogram (EEG) time series data from four epileptic patients. A non-seizure state is a period that is free of any part of an epileptic seizure, including the transition to a fully developed episode. EEG measurements are typically contaminated with a large amount of non- neurophysiological source information, generally called artifact, which arises, for example, from eye movement, muscle tension, and physical motion. The first objective of this study is to gain some insight into how much variability in analysis results to be expected from patients having similar clinical characteristics. The second objective is to investigate the impact of eye movement on the analysis results. A special feature presented here is the introduction and testing of a filter for eye movement artifact. The third objective is to determine if neurophysiological activity as viewed from two adjacent channels appears dynamically to be the same.
Expert System for the Optimal Design and Execution of Successful Completion Practices Using Artificial Bayesian Intelligence (2011)

Abstract To the best of the authors' knowledge, there are no standard guidelines to help in the effective design of completion practices. Many completions have been analyzed in this project, resulting in the best practices, as outlined in this paper. The objective of this paper is to propose a set of guidelines for the optimal completion design, by integrating current best practices through a decision-making system based on Artificial Bayesian Intelligence. Best completion practices collected from data, models, and experts' opinions, are integrated into a Bayesian Network BN to simulate likely scenarios of its use, that will honor efficient designs when dictated by varying well objectives, well types, temperatures, pressures, rock and fluid properties. The described decision-making model follows a causal and uncertainty-based approach capable of simulating realistic conditions on the use of completion operations. For instance, the use of water swelling packer dictates the use of organic acids instead of HCl acids. However, rock type and well geometry affect our selection of treatment fluids. Another example is selection of sand control method based on rock properties. The paper also outlines best operational practices in fracturing, sand control, perforation, treatment and completion fluids, multilateral junction level selection and lateral completion. The paper also discusses in details special well completions. Completion experts' opinions were considered in building the model in this paper. The outcome of this paper is a user-friendly tool, where one can easily find the specific subject of interest, and by the click of a button, get the related information you are seeking. Field cases will also be discussed to validate this work.
New Bandwidth Efficient Relaying Schemes in Cooperative Cognitive Two-Way Relay Networks With Physical Layer Security (2016)

In this paper, a new cooperative two-way cognitive relaying scheme is proposed. In this model, a primary user (PU) network consisting of two PU sources communicate with each other via a single amplify-and-forward (AF) relay. In addition, a secondary user (SU) source transmits its data to an SU destination via the same PU relay node. To mitigate the SU interference caused to the PU network, the PU network considers the SU network pairs as two additional relay nodes helping the original PU relay node in improving the PU network performance. As a reward for its cooperation, the PU network allows the SU network to communicate simultaneously via the PU relay node by using the decode-and-forward protocol. The proposed system allows the transmission of four PU symbols and one SU symbol in four/three time slots resulting in a bandwidth efficiency of 1.25/1.67 based on the cooperative scheme, respectively. Two power allocation optimization problems are formulated: the first problem minimizes the weighted sum of the average symbol error probability of both PU and SU systems, whereas the second problem maximizes the total achievable sum rate of the PU and SU networks. Lagrangian multiplier method is used to find the optimal solutions for both problems under the constraint of maximum allowable power budget. In addition, the paper investigates how the proposed model improves the PU physical layer security performance against a single passive eavesdropper. The results show that the error performance of the proposed relay selection model outperforms the conventional two-way relaying networks with AF protocol. Moreover, findings illustrate that the total achievable sum rate of the proposed relay elimination model is higher than the total achievable rate of the conventional two-way relaying model. From secrecy point of view, the proposed model is shown to achieve a nonzero secrecy rate that improves the PU system security against eavesdropping attacks.
Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists (1999)

Transient lower esophageal sphincter (LES) relaxation is the major mechanism of gastroesophageal reflux. This study uses an established ferret model to evaluate GABA(B) receptor agonists' ability to reduce triggering of transient LES relaxations. One hundred sixty manometric/pH studies were performed on 18 conscious ferrets. In untreated animals, intragastric infusion of 25 ml glucose (pH 3.5) led to 2.0 +/- 0.6 reflux episodes over the first 30 min. Twenty-nine of forty-seven reflux episodes occurred during transient LES relaxation, and 18 occurred after downward drifts (<1 mmHg/s) in basal LES pressure. The GABA(B) receptor agonists baclofen (7 micromol/kg ip), CGP-44532, and SKF-97541 (both ED(50) <0.3 micromol/kg) reduced reflux episodes and transient LES relaxations. The putative peripherally selective GABA(B) receptor agonist 3-aminopropylphosphinic acid (80-240 micromol/kg) was ineffective, as was the GABA(A) receptor agonist muscimol (5 micromol/kg). Baclofen's inhibition of transient LES relaxations and reflux was unaffected by low-affinity GABA(B) receptor antagonists CGP-35348 and CGP-36742 at 100 micromol/kg but was reversed by higher-affinity CGP-54626 and CGP-62349 (0.7 micromol/kg) or by CGP-36742 at 200 micromol/kg. Therefore, GABA(B) receptor inhibition of reflux shows complex pharmacology. Our and other data indicate the therapeutic potential for these drugs.
ChemInform Abstract: In vitro Antifungal Activity and Structure‐Activity Relationship Studies of Novel cis‐5‐Acyloxyalkyl‐3‐phenyl‐3‐(1H‐imidazol‐1‐ylmethyl)‐2‐methylisoxazolidine Derivatives. (1989)

ChemInformVolume 20, Issue 26 Other Subjects ChemInform Abstract: In vitro Antifungal Activity and Structure-Activity Relationship Studies of Novel cis-5-Acyloxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine Derivatives. D. M. MARYNIAK, D. M. MARYNIAK Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorG. B. MULLEN, G. B. MULLEN Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorS. D. ALLEN, S. D. ALLEN Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorJ. T. MITCHELL, J. T. MITCHELL Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorC. R. KINSOLVING, C. R. KINSOLVING Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorV. S. GEORGIEV, V. S. GEORGIEV Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this author D. M. MARYNIAK, D. M. MARYNIAK Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorG. B. MULLEN, G. B. MULLEN Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorS. D. ALLEN, S. D. ALLEN Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorJ. T. MITCHELL, J. T. MITCHELL Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorC. R. KINSOLVING, C. R. KINSOLVING Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorV. S. GEORGIEV, V. S. GEORGIEV Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this author First published: June 27, 1989 https://doi.org/10.1002/chin.198926337AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume20, Issue26June 27, 1989 RelatedInformation