gebhart/patrepeval huggingface dataset:
[Vectorcardiographic analysis of late potentials]. (1986)

We analyzed by high amplification vectorcardiography the morphology of the QRS ending loop and the ST segment of patients with previously recorded Lown 4A, 4B ventricular arrhythmias and the healthy subject. Eight patients were affected by ischemic heart disease and 7 by arrhythmogenic right ventricular dysplasia. All had some irregularities at the end of the QRS or in the ST segment, on the standard ECG. The VCG showed one or more of these three morphologies: complete or incomplete ring, rapidly inscripted isodi-triphasic potentials, sinusoidal irregularities. In the 20 healthy subjects, the loop corresponding to the last 30 msec of the QRS, till the end of the afferent portion of T, was regular, without any particular morphology. We think that these aspects could be related to delayed fragmentation of the ventricular depolarization.
Providing Simulated Online and Mobile Learning Experiences in a Prison Education Setting (2014)

This article reports on the preliminary findings, design criteria and lessons learned while developing and piloting an alternative to traditional print-based education delivery within a prison environment. PLEIADES (Portable Learning Environments for Incarcerated Distance Education Students), was designed to provide incarcerated students with access to internet-independent secure digital and mobile technologies. An internet-independent version of Moodle was developed to complement course readings deployed on eReaders. The aim of the project was to increase access to and participation in higher education courses that are increasingly offered exclusively online. The article begins with an overview of the current provision of education within prison environments and introduces the rationale for commencing the project. The research findings of the project trial are discussed and the paper concludes with the lessons learned and implications for further research, development and implementation.
Metal complexes with tetrapyrrole ligands. 40. Cerium(IV) bis(octaethylporphyrinate) and dicerium(III) tris(octaethylporphyrinate): Parents of a new family of lanthanoid double-decker and triple-decker molecules (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal complexes with tetrapyrrole ligands. 40. Cerium(IV) bis(octaethylporphyrinate) and dicerium(III) tris(octaethylporphyrinate): Parents of a new family of lanthanoid double-decker and triple-decker moleculesJohann W. Buchler, Andre. De Cian, Jean. Fischer, Martina. Kihn-Botulinski, Helmut. Paulus, and Raymond. WeissCite this: J. Am. Chem. Soc. 1986, 108, 13, 3652–3659Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/ja00273a018https://doi.org/10.1021/ja00273a018research-articleACS PublicationsRequest reuse permissionsArticle Views998Altmetric-Citations176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The expression of emotions by text and speech (2014)

The paper introduced an audiobook Pingfan de Shijie with plentiful information of emotions. Via the emotion labeling of more than 6000 sentences respectively depending on context and audio, the commonalities and differences of the two layers of annotation were checked from two aspects: whether the sentences are neutral or un-neutral, and which emotional categories these sentences belong to. The results show that the subjective sentences in text layer can be read as neutral speech sentences, while large amount of objective sentences in text layer must be read as effective speech sentences. Finally, the causes to the annotation difference were analyzed and considerations in the process of emotional modeling from text to speech in speech synthesis were raised by this paper.
Physikit (2016)

Internet of things (IoT) devices and sensor kits have the potential to democratize the access, use, and appropriation of data. Despite the increased availability of low cost sensors, most of the produced data is "black box" in nature: users often do not know how to access or interpret data. We propose a "human-data design" approach in which end-users are given tools to create, share, and use data through tangible and physical visualizations. This paper introduces Physikit, a system designed to allow users to explore and engage with environmental data through physical ambient visualizations. We report on the design and implementation of Physikit, and present a two-week field study which showed that participants got an increased sense of the meaning of data, embellished and appropriated the basic visualizations to make them blend into their homes, and used the visualizations as a probe for community engagement and social behavior.
Assigning distinct identities to sites on an anonymous distributed system (2003)

A distributed algorithm that assigns distinct and ordered identities to the sites of a connect anonymous distributed system is presented. The basis for this algorithm is the sequential distributed traversal scheme, the sequential aspect of which ensures that all sites are systematically visited in mutual exclusion. Such an algorithm allows the definition of sites to be independent of particular of initial values (as far as identities are concerned).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Green Extraction of Natural Products: Concept and Principles (2012)

The design of green and sustainable extraction methods of natural products is currently a hot research topic in the multidisciplinary area of applied chemistry, biology and technology. Herein we aimed to introduce the six principles of green-extraction, describing a multifaceted strategy to apply this concept at research and industrial level. The mainstay of this working protocol are new and innovative technologies, process intensification, agro-solvents and energy saving. The concept, principles and examples of green extraction here discussed, offer an updated glimpse of the huge technological effort that is being made and the diverse applications that are being developed.
Synthesis and Photochemical Evaluation of Iodinated Squarylium Cyanine Dyes (2005)

Abstract Several (multiply) iodinated squarylium cyanine dyes of type 1 and 8 (see Scheme and Table ), derived from 1,3‐benzothiazole and 6‐iodo‐1,3‐benzothiazole, were synthesized as potential new photosensitizers, with absorptions in the 700‐nm region. Their ability to generate singlet oxygen ( 1 O 2 ) was assessed by luminescence‐decay measurement in the near‐IR. Some of these new dyes show interesting photophysical properties, and may be potentially used in photodynamic therapy (PDT).
Serological titers to various leptospiral serovars before and after vaccinating gilts with three commercial vaccines. (1990)

The antibody response to various leptospiral serovars was evaluated in six-month-old gilts vaccinated with three commercial vaccines, each containing five leptospiral serovars.All three vaccines elicited a significant postvaccinal antibody response to Leptospira canicola, grippotyphosa and icterohaemorrhagiae (copenhageni). The antibody response to the other leptospiral antigens in the vaccines varied among the vaccinates. None of the vaccinated groups developed significant titers to L. hardjo. Two of the three vaccines elicited a significant postvaccinal response to L. pomona, but in each case the titer mean of the vaccinated group was <1/100. Although not among the antigens in the vaccines, titers to L. bratislava increased in all vaccinated groups, except one, and in one control group.
Target Practice: Lessons from Phase III Trials with Bevacizumab and Vatalanib in the Treatment of Advanced Colorectal Cancer (2007)

Vascular endothelial growth factor (VEGF) is one of the most important factors involved in tumor angiogenesis and has become an important target for anticancer treatment. In 2004, this approach was validated in a randomized, controlled phase III clinical trial. It was shown that the addition of bevacizumab, a humanized monoclonal antibody against VEGF-A, to conventional chemotherapy prolonged survival over chemotherapy alone in patients with metastatic colorectal cancer. In this review, we discuss the results of the clinical trials that have led to the incorporation of antiangiogenic agents into the treatment of patients with advanced colorectal cancer. We limit ourselves to the two agents that have been tested extensively in phase III trials: bevacizumab and vatalanib, a small molecule tyrosine kinase inhibitor against VEGF receptors. In addition, we discuss the adverse effects of bevacizumab and vatalanib and the clinical management of the side effects.
Introduction (2019)

Many activities in which young children spontaneously engage are intrinsically scientific, or can be made to be so: blowing bubbles, playing with sand and water and looking at flowers or spiders’ webs. Scientific processes are certainly very important aspects of Early Years science. Children’s emotional disposition towards learning, and their responses to natural phenomena, can serve as the starting points for developing the attitudes of curiosity, open-mindedness and respect for evidence. Design and technology–spoken as a singular rather than plural term –is a holistic activity, involving thinking and doing, action and reflection. In this respect it parallels many approaches to Early Years education, including ‘HighScope’ with its emphasis upon the ‘plan-do-review’ cycle to develop intentionality in children’s play. Young children can engage with coding and computational thinking as when giving instructions to a programmable toy such as a Beebot or solving an online maze. The chapter also presents an overview of the key concepts discussed in this book.
Who Can Find My Devices? Security and Privacy of Apple's Crowd-Sourced Bluetooth Location Tracking System (2021)

Overnight, Apple has turned its hundreds-of-million-device ecosystem into the world's largest crowd-sourced location tracking network called offline finding (OF). OF leverages online finder devices to detect the presence of missing offline devices using Bluetooth and report an approximate location back to the owner via the Internet. While OF is not the first system of its kind, it is the first to commit to strong privacy goals. In particular, OF aims to ensure finder anonymity, untrackability of owner devices, and confidentiality of location reports. This paper presents the first comprehensive security and privacy analysis of OF. To this end, we recover the specifications of the closed-source OF protocols by means of reverse engineering. We experimentally show that unauthorized access to the location reports allows for accurate device tracking and retrieving a user's top locations with an error in the order of 10 meters in urban areas. While we find that OF's design achieves its privacy goals, we discover two distinct design and implementation flaws that can lead to a location correlation attack and unauthorized access to the location history of the past seven days, which could deanonymize users. Apple has partially addressed the issues following our responsible disclosure. Finally, we make our research artifacts publicly available.
Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition (2006)

Behavioural pharmacology is an interdisciplinary field at the intersection of several research areas that ultimately lead to the development of drugs for clinical use and build understanding of how brain functions enable cognition and behaviour. In this article, the development of behavioural pharmacology in the UK is briefly surveyed, and the current status and success of the field is highlighted by the progress in our understanding of learning and memory that has resulted from discoveries in glutamate receptor pharmacology allied to theoretical and methodological advances in behavioural neuroscience. We describe the original breakthrough in terms of the role of NMDA receptors in hippocampal-mediated spatial learning and long-term potentiation, and review recent advances that demonstrate the involvement of glutamate receptor in working memory, recognition memory, stimulus-response learning and memory, and higher cognitive functions. We also discuss the unique functions of NMDA receptors and the fundamental role of AMPA receptors in processes that are common to some of these forms of memory, including encoding, consolidation and retrieval.
Induction of the cholesteric mesophase in nematic liquid crystals: mechanism and application to the determination of bridged biaryl configurations (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInduction of the cholesteric mesophase in nematic liquid crystals: mechanism and application to the determination of bridged biaryl configurationsGiovanni Gottarelli, Marcel Hibert, Bruno Samori, Guy Solladie, Gian P. Spada, and Richard ZimmermannCite this: J. Am. Chem. Soc. 1983, 105, 25, 7318–7321Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ja00363a019https://doi.org/10.1021/ja00363a019research-articleACS PublicationsRequest reuse permissionsArticle Views890Altmetric-Citations179LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optoelectronic switch and continuously tunable filter based on a liquid crystal waveguide (2001)

In this paper the possibility of using ferroelectric liquid crystals in active waveguide devices is explored through the analysis of an integrated electro-optic switch and a continuously tunable filter. The design and the analysis of tow electro-optical devices, based on a Bragg grating integrated in a glass waveguide having liquid crystal as cover, are presented. The integrated optics structure allows to change the reflectivity of the Bragg mirror by means of electro-optic effects of smectic liquid crystals. The integrated fast electro-optic switch is based on electro- optic properties of smectic C<SUP>*</SUP> in the Surface Stabilized liquid crystal structure and on the selective properties of integrated Bragg grating. It presents the output directly in the frequency domain, overcoming the typical problems of intensity dependent devices, without requiring external electronic circuit. Moreover the possibility to realize a novel continuously tunable integrated filter, combining the linear electro-optic effect of smectic A<SUP>*</SUP> and the selective property of Bragg grating, has been explored. The proposed filter is characterized by a narrow bandwidth, desired feature for WDM technique. The principal advantages of such device include fast tuning speed, wide tuning range, low power consumption and low cost.
Characterization of new human pancreatic cancer cell lines which propagate in a protein-free chemically defined medium. (1990)

Many human cancer cell lines which have been maintained in fetal bovine serum (FBS)-supplemented medium produce and secrete many substances such as transferrin, alpha 1-antitrypsin, alpha 2-macroglobulin, alkaline phosphatase, gamma-glutamyltranspeptidase, creatine kinase, carcinoembryonic antigen, alpha-fetoprotein, carbohydrate antigen 19/9, and cytokines including colony-stimulating factors and transforming growth factor, and further they may produce small amounts of unknown substances. Usually, small amounts of substances have to be concentrated as highly as possible for detection, but FBS interferes with this procedure. A protein-free culture system is an ideal method for detecting small quantities of substances which originate from cancer cells without interference by FBS. However, we were concerned that protein-free culture may interrupt the production of the substances which have been produced in FBS-supplemented medium. In this study, we investigated the productibility of 46 kinds of well-known substances in ten newly established cell lines derived from human pancreatic cancer. These cell lines were propagated in a protein-free non-FBS-supplemented medium. Of the ten cases, one cell line alone that was derived from acinal cell carcinoma propagated as a semisuspension; on the other hand, nine cell lines that were derived from ductal cell carcinoma propagated as monolayers without piling up. This method prolongs the doubling time, which is not affected by the addition of FBS. The spent media of these cell lines were collected aseptically after the removal of cell debris and concentrated by ultrafiltration using a Pericon cassette followed by lyophilization. Using 46 kinds of available antibodies, we investigated whether or not the substances which react to these antibodies could be detected in the spent media and in the cells by enzyme-linked immunosorbent assay, Western blot analysis, and immunocytochemistry. Among these cell lines, HPC-Y11 produced and secreted the most kinds of substances, and the production of those substances was lowest in HPC-Y0. In conclusion, our protein-free culture system can be available in every laboratory, since this is not only an economical method, but also an effective method for the saving of purification procedures. Moreover, this is a most suitable method for surveying unknown substances derived from cancer cell lines.
Voltage Pulses Change Neural Interface Properties and Improve Unit Recordings With Chronically Implanted Microelectrodes (2006)

Current neuroprosthetic systems based on electro-physiological recording have an extended, yet finite working lifetime. Some posited lifetime-extension solutions involve improving device biocompatibility or suppressing host immune responses. Our objective was to test an alternative solution comprised of applying a voltage pulse to a microelectrode site, herein termed "rejuvenation." Previously, investigators have reported preliminary electrophysiological results by utilizing a similar voltage pulse. In this study we sought to further explore this phenomenon via two methods: 1) electrophysiology; 2) an equivalent circuit model applied to impedance spectroscopy data. The experiments were conducted via chronically implanted silicon-substrate iridium microelectrode arrays in the rat cortex. Rejuvenation voltages resulted in increased unit recording signal-to-noise ratios (10% +/- 2%), with a maximal increase of 195% from 3.74 to 11.02. Rejuvenation also reduced the electrode site impedances at 1 kHz (67% +/- 2%). Neither the impedance nor recording properties of the electrodes changed on neighboring microelectrode sites that were not rejuvenated. In the equivalent circuit model, we found a transient increase in conductivity, the majority of which corresponded to a decrease in the tissue resistance component (44% +/- 7%). These findings suggest that rejuvenation may be an intervention strategy to prolong the functional lifetime of chronically implanted microelectrodes.
Transforming Growth Factor- <i>β</i> Signaling in Normal and Malignant Hematopoiesis (2007)

Transforming growth factor-beta (TGF-beta) is an important physiologic regulator of cell growth and differentiation. TGF-beta has been shown to inhibit the proliferation of quiescent hematopoietic stem cells and stimulate the differentiation of late progenitors to erythroid and myeloid cells. Insensitivity to TGF-beta is implicated in the pathogenesis of many myeloid and lymphoid neoplasms. Loss of extracellular TGF receptors and disruption of intracellular TGF-beta signaling by oncogenes is seen in a variety of malignant and premalignant states. TGF-beta can also affect tumor growth and survival by influencing the secretion of other growth factors and manipulation of the tumor microenvironment. Recent development of small molecule inhibitors of TGF-beta receptors and other signaling intermediaries may allow us to modulate TGF signaling for future therapeutic interventions in cancer.
A Central Role for a Single c-Myb Binding Site in a Thymic Locus Control Region (1995)

Locus control regions (LCRs) are powerful assemblies of cis elements that organize the actions of cell-type-specific trans-acting factors. A 2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron, which controls expression in thymocytes, is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin. Prior analyses have demonstrated that the enhancer contains a 28-bp core region and local adjacent augmentative cis elements. We now show that the core contains a single critical c-Myb binding site. In both transiently cotransfected human cells and stable chromatin-integrated yeast cells, c-Myb strongly transactivated reporter constructs that contained polymerized core sequences. c-Myb protein was strongly evident in T lymphoblasts in which the enhancer was active and was localized within discrete nuclear structures. Fetal murine thymus exhibited a striking concordance of endogenous c-myb expression with that of mouse ADA and human ADA LCR-directed transgene expression. Point mutation of the c-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in transgenic thymocytes. Within the context of a complex enhancer and LCR, c-Myb can act as an organizer of thymocyte-specific gene expression via a single binding site.