gebhart/patrepeval huggingface dataset:
Recent Developments and Novel Applications of Laser Shock Peening: A Review (2021)

By inducing work hardening and beneficial compressive residual stresses in near‐surface regions, laser shock peening (LSP) improves the fatigue performance of many metallic components. In recent years, LSP has found many new applications in emerging fields: additive manufacturing, ceramics, and metallic glasses. In addition, innovative process development based on LSP has been reported, which includes warm LSP, cryogenic LSP, electropulsing‐assisted LSP, laser peening without coating, femotosecond LSP, and laser peen forming. Herein, a comprehensive review of the LSP process with a focus on the novel applications and innovative process development is aimed for. The history of LSP with key events is briefly reviewed. The fundamental mechanisms of LSP, including the generation of shockwaves by a high‐energy pulsed laser, the generation of compressive residual stresses by the shockwave, and its effect on crack propagation, and how LSP induces grain refinement are also discussed. The effects of compressive residual stresses and grain refinement on the mechanical properties of metallic materials are reviewed. Recent developments in LSP, such as innovative process development based on LSP and its novel applications, are discussed. Finally, the current challenges the LSP technology faces and its future directions are also discussed.
Temporally consistent multi-class video-object segmentation with the Video Graph-Shifts algorithm (2011)

We present the Video Graph-Shifts (VGS) approach for efficiently incorporating temporal consistency into MRF energy minimization for multi-class video object segmentation. In contrast to previous methods, our dynamic temporal links avoid the computational overhead of using a fully connected spatiotemporal MRF, while still being able to deal with the uncertainties of the exact inter-frame pixel correspondence issues. The dynamic temporal links are initialized flexibly for balancing between speed and accuracy, and are automatically revised whenever a label change (shift) occurs during the energy minimization process. We show in the benchmark CamVid database and our own wintry driving dataset that VGS improves the issue of temporally inconsistent segmentation effectively - enhancements of up to 5% to 10% for those semantic classes with high intra-class variance. Furthermore, VGS processes each frame at pixel resolution in about one second, which provides a practical way of modeling complex probabilistic relationships in videos and solving it in near real-time.
Multi-model Based Optimization for Stream Query Processing. (2006)

With recent explosive growth of sensors and instruments, large scale data-intensive and computation-intensive applications are emerging, especially in scientific fields. Helping scientists to efficiently, even in real time, process queries over those large scale scientific streams thus has great demand. However, query optimization for high volume stream applications– in particular its core component, the evaluation model– has not been systematically studied. We observe that evaluating stream query plans should consider three aspects: output rate, computation cost and memory consumption. However, to our knowledge, no existing research on evaluating stream query plans consider all three metrics. In this paper, we propose a new combined optimization goal which leverages all these aspects and develop a multi-model based optimization framework to accomplish this goal. Specifically, we build three models to evaluate a plan’s output rate, computation cost and memory consumption respectively. Based on such three models, we search for an optimal plan while considering systems’s computation resource and memory constraints. We also experimentally evaluate our optimization framework.
An asynchronous architecture model for behavioral synthesis (2003)

An asynchronous architecture model for behavioral synthesis is presented. The basis of the model lies in a distributed control structure consisting of multiple communicating processes. Data processing is performed by self-timed modules. Signal transition graphs (STGs) are used to specify the behavior of the control processes. By using existing synthesis procedures for STGs, circuits based on the presented architecture model are proved to be realizable and hazard-free.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The First Head Up Display Introduced by General Motors (1989)

<div class="htmlview paragraph">The first production configured head up display (HDD) wa8 introduced in the United States in the 1988 Oldsmobile Cutlass Supreme Indianapolis 500 Pace Car Parade Convertibles. The design and performance of this HUD uses a vacuum fluorescent display tube (VFD) and reflective optics, including the standard production windshield as the final element, and produces a virtual image of a digital speedometer and selected telltales just above the hood line in the driver's central vision area at approximately front bumper range. The unit's functional and physical design minimize modification of existing instrument panel structures and interfaces while providing essential features and performance for consumer satisfaction. Human factors engineering contributed to this application; supporting studies and simulation efforts are summarized to substantiate the design decisions.</div>
Vascular interventions guided by ultrafast MR imaging: Evaluation of different materials (1994)

Abstract The ability of MRI to acquire not only anatomical but also functional information makes MRI guided vascular interventions an interesting goal. Recent developments in ultrafast MR imaging sequences such as fast gradient echo or echo planar (EPI) mean that not only real time MRI but also MRI guided vascular interventions are real possibilities for the not too distant future. However, currently available guide wires and catheters are potentially unusable in MRI because they are either ferromagnetic or MRI invisible. In order to find different materials suitable for real time MRI, various devices were examined with fast gradient echo and interleaved EPI pulse sequences. The measurements were performed using a continuously running, pseudo real time MRI system to investigate the dynamic imaging behavior under guide wire insertion. Suggestions are made as how to construct guide wires and catheters, which can be visualized with ultrafast imaging sequences, while not causing prohibitive artifacts or image distortions.
Effects of Soluble and Insoluble Fiber Preparations Isolated from Oat, Barley, and Wheat on Liver Cholesterol Accumulation in Cholesterol-Fed Rats. (1993)

Effects of soluble and insoluble fiber preparations isolated from defatted oat, barley, and wheat on liver cholesterol accumulation were examined in cholesterol-fed rats. The soluble and insoluble fiber preparations were isolated by a modification of the procedure of Asp et al. Male Sprague-Dawley rats, aged 5 weeks, were fed a control diet containing 5% cellulose or diets containing soluble and insoluble fiber preparations for 9 days. Soluble fiber preparations from oat, barley, and wheat were added to diets corresponding to 1.9, 2.8, and 0.6% fiber, respectively. Insoluble fiber preparations from oat, barley, and wheat were added to diets corresponding to 3.1, 2.2, and 4.4% fiber, respectively. All of the soluble fiber preparations suppressed liver cholesterol accumulation, but they did not suppress the elevation of plasma cholesterol concentrations. A significant inverse relationship between the quantity of ingested soluble fiber and liver cholesterol accumulation was observed; n = 28, r = -0.943, p < 0.0001. None of the insoluble fiber preparations had any significant effect on liver and plasma cholesterol concentrations. These results indicate that the water-soluble fractions of oat, barley, and wheat are the active components that suppressed liver cholesterol accumulation, and that these effects are related to the quantity of ingested soluble fiber.
A Retrograde Signal from Calsequestrin for the Regulation of Store-operated Ca2+ Entry in Skeletal Muscle (2003)

Calsequestrin (CSQ) is a high capacity Ca(2+)-binding protein present in the lumen of sarcoplasmic reticulum (SR) in striated muscle cells and has been shown to regulate the ryanodine receptor Ca(2+) release channel activity through interaction with other proteins present in the SR. Here we show that overexpression of wild-type CSQ or a CSQ mutant lacking the junction binding region (amino acids 86-191; Delta junc-CSQ) in mouse skeletal C2C12 myotube enhanced caffeine- and voltage-induced Ca(2+) release by increasing the Ca(2+) load in SR, whereas overexpression of a mutant CSQ lacking a Ca(2+) binding, aspartate-rich domain (amino acids 352-367; Delta asp-CSQ) showed the opposite effects. Depletion of SR Ca(2+) by thapsigargin initiated store-operated Ca(2+) entry (SOCE) in C2C12 myotubes. A large component of SOCE was inhibited by overexpression of wild-type CSQ or Delta junc-CSQ, whereas myotubes transfected with Delta asp-CSQ exhibited normal function of SOCE. These results indicate that the aspartate-rich segment of CSQ, under conditions of overexpression, can sustain structural interactions that interfere with the SOCE mechanism. Such retrograde activation mechanisms are possibly taking place at the junctional site of the SR.
Porin-Mediated Antibiotic Resistance in <i>Neisseria gonorrhoeae</i> : Ion, Solute, and Antibiotic Permeation through PIB Proteins with <i>penB</i> Mutations (2006)

Neisseria gonorrhoeae has two porins, PIA and PIB, whose genes (porA and porB, respectively) are alleles of a single por locus. We recently demonstrated that penB mutations at positions 120 and 121 in PIB, which are presumed to reside in loop 3 that forms the pore constriction zone, confer intermediate-level resistance to penicillin and tetracycline (M. Olesky, M. Hobbs, and R. A. Nicholas, Antimicrob. Agents Chemother. 46:2811-2820, 2002). In the present study, we investigated the electrophysiological properties as well as solute and antibiotic permeation rates of recombinant PIB proteins containing penB mutations (G120K, G120D/A121D, G120P/A121P, and G120R/A121H). In planar lipid bilayers, the predominant conducting state of each porin variant was 30 to 40% of the wild type, even though the anion selectivity and maximum channel conductance of each PIB variant was similar to that of the wild type. Liposome-swelling experiments revealed no significant differences in the permeation of sugars or beta-lactam antibiotics through the wild type or PIB variants. Although these results are seemingly contradictory with the ability of these variants to increase antibiotic resistance, they are consistent with MIC data showing that these porin mutations confer resistance only in strains containing an mtrR mutation, which increases expression of the MtrC-MtrD-MtrE efflux pump. Moreover, both the mtrR and penB mutations were required to decrease in vivo permeation rates below those observed in the parental strain containing either mtrR or porin mutations alone. Thus, these data demonstrate a novel mechanism of porin-mediated resistance in which mutations in PIB have no affect on antibiotic permeation alone but instead act synergistically with the MtrC-MtrD-MtrE efflux pump in the development of antibiotic resistance in gonococci.
Effects of grain size, hardness, and stress on the magnetic hysteresis loops of ferromagnetic steels (1987)

Effects of grain size, hardness, and stress on the magnetic hysteresis loops of AISI 410 stainless steel and SAE 4340 steel specimens were investigated experimentally. It was observed that both hardness and stress significantly influenced the hysteresis loops, while the grain size had a minimal effect. For each material, the mechanically harder specimen was more difficult to magnetize. Upon application of uniaxial stress, the magnetic induction increased under tension and decreased under compression, with the sides of the hysteresis loops becoming inclined more toward the vertical axis under tension and the horizontal axis under compression. For each material, the effects of stress on the hysteresis loops were greater for the mechanically softer specimen and exhibited an inverse relationship to the hardness. The effects of stress were not dependent on grain size.
Expansion of the ‘3 + 1’ concept of oxorhenium-thiolate chemistry to cationic and binuclear complexes (1998)

The reactions of [(n-C4H9)4N] [ReOBr4(OPPh3)] with the appropriate tridentate and monodentate thiolate ligands yield the ‘3 + 1’ oxorhenium(V) complexes [ReO(SCH2CH2OCH2CH2S)(SCH2C6H4-4-OMe)] (1), [ReO(SCH2CH2OCH2CH2S)(SC5H4NH)]Br (2) and [Re2O2(SCH2CH2OCH2CH2S)3] (3). The versatility of this approach for the synthesis of oxorhenium(V) core complexes is manifest in the preparations of the cationic complex of 2 and of the thiolate bridged binuclear complex 3.
Mapping the Von Hippel — Lindau disease tumour suppressor gene: identification of germline deletions by pulsed field gel electrophoresis (1993)

Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome in which affected individuals have a greatly increased predisposition to the development of haemangioblastomas of the central nervous system and retina, renal cell carcinoma and phaeochromocytoma. The VHL gene has been mapped to chromosome 3p25-p26 by genetic linkage studies and we have previously demonstrated that the VHL gene is tightly linked to the D3S601 locus (Zmax = 18.86 at theta = 0.0) suggesting that D3S601 maps close to the VHL disease gene. We have constructed a long range physical map around D3S601 and screened 91 VHL patients from 80 kindreds for germline rearrangements using pulsed field gel electrophoresis. Two patients showed abnormal fragments in Mlul digested DNA probed with D3S601. Further analysis was consistent with both patients having germline deletions (approximately 120 kb and 50 kb) telomeric to D3S601. These results have (i) established the position of the VHL disease gene with respect to D3S601, (ii) refined the localisation of the VHL disease gene to a small region (approximately 50 kb) of chromosome 3p25-p26 and (iii) excluded the plasma membrane Ca(+)+-transporting ATPase isoform 2 (PMCA-2) gene as a candidate gene for VHL disease.
Analysis of the ColE1 stability determinant Rcd (1999)

Multimer formation is an important cause of instability for many multicopy plasmids. Plasmid CoIE1 is maintained stably because multimers are converted to monomers by Xer-mediated site-specific recombination at the cer site. However, multimer resolution is not the whole story; inactivation of a promoter (Pcer) within cer causes plasmid instability even though recombination is unaffected. The promoter directs the synthesis of a short transcript (Rcd) which is proposed to delay the division of multimer-containing cells. Mapping of the 5' terminus of Rcd confirms that transcription initiates from Pcer. The 3' terminus shows considerable heterogeneity, consistent with a primary transcript of 95 nt being degraded via intermediates of 79 and 70 nt. Secondary structure predictions for Rcd are presented. Of four mutations which abolish Rcd-mediated growth inhibition, one reduces the activity of Pcer while the other three map to the rcd coding sequence and reduce the steady-state level of the transcript. RNA folding analysis suggests that these three mutant transcripts adopt a common secondary structure in which the major stem-loop differs from that of wild-type Rcd. A survey of 24 cer-like multimer resolution sites revealed six which contain Pcer-like sequences. The putative transcripts from these sites have similar predicted secondary structures to Rcd and contain a highly conserved 15 base sequence. To test the hypothesis that Rcd acts as an anti-sense RNA, interacting with its target gene(s) through the 15 nt sequence, we used DNA hybridization and sequence analysis to find matches to this sequence in the Escherichia coli chromosome. Our failure to find plausible anti-sense targets has led to the suggestion that Rcd may interact directly with a protein target.
North American Prodrome Longitudinal Study: A Collaborative Multisite Approach to Prodromal Schizophrenia Research (2007)

This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Prodromal Syndromes, and how baseline and follow-up data were aggregated for 888 at risk and comparison subjects. Data are presented describing the demographic, academic/work, and diagnostic characteristics of 3 relevant subgroups: persons at heightened clinical risk for psychosis, help-seeking comparison subjects, and nonpsychiatric controls. The NAPLS data set will be used to explore a series of questions related to prodromal psychosis, including the descriptive phenomenology of currently accepted diagnostic criteria, conversion rates over a 30-month period, predictors of psychosis onset and functional disability, and the impact of early treatment on the course of prodromal symptoms.
Ethylene-induced Defoliation in Ficus Species and Ethylene Depletion by Soil Bacteria in Peat-amended Media and in Vitro (1988)

Abstract Ficus benjamina L. and F. stricta Miguel. were exposed to various concentrations of ethylene gas and ethephon to determine their sensitivity to defoliation. F. stricta was more sensitive to ethephon, whereas F. benjamina was more sensitive to ethylene gas. Plants growing in medium exposed to ethylene gas depleted ethylene from the ambient atmosphere. Double-autoclaving the peat : perlite growing medium prevented ethylene depletion, indicating soil microbes as the source of depletion. Bacterial isolates from the medium depleted ethylene in vitro; fungal isolates did not deplete ethylene. The eight species of bacteria isolated into pure culture depleted 9% to 46% of the ethylene from the flask atmosphere over 5 days, with two Enterobacter spp. and one Pseudomonas sp. being the most effective depleters. Chemical name used: (2-chloroethyl)phosphonic acid (ethephon).
Charged ultrafiltration membrane for permeation of proteins (1988)

Abstract Polyacrylonitrile‐ g ‐poly( N , N ‐dimethylaminoethyl methacrylate) was synthesized photochemically and quaternized. The positively charged membranes made from the quaternized graftcopolymer showed high ultrafiltration rate for water by adding poly(vinyl alcohol) to casting solution and washing it out after the casting. In buffered saline solution, the permeability of the membranes was very small at pH below isoelectric point of albumin but increased markedly at higher pH. On the other hand, the permeability for γ‐globulin was very small and did not show any pH dependence.
Cellobiose Transport by Mixed Ruminal Bacteria from a Cow (1999)

The transport of cellobiose in mixed ruminal bacteria harvested from a holstein cow fed an Italian ryegrass hay was determined in the presence of nojirimycin-1-sulfate, which almost inhibited cellobiase activity. The kinetic parameters of cellobiose uptake were 14 microM for the Km and 10 nmol/min/mg of protein for the Vmax. Extracellular and cell-associated cellobiases were detected in the rumen, with both showing higher Vmax values and lower affinities than those determined for cellobiose transport. The proportion of cellobiose that was directly transported before it was extracellularly degraded into glucose increased as the cellobiose concentration decreased, reaching more than 20% at the actually observed levels of cellobiose in the rumen, which were less than 0.02 mM. The inhibitor experiment showed that cellobiose was incorporated into the cells mainly by the phosphoenolpyruvate phosphotransferase system and partially by an ATP-dependent and proton-motive-force-independent active transport system. This finding was also supported by determinations of phosphoenolpyruvate phosphotransferase-dependent NADH oxidation with cellobiose and the effects of artificial potentials on cellobiose transport. Cellobiose uptake was sensitive to a decrease in pH (especially below 6.0), and it was weakly but significantly inhibited in the presence of glucose.
Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro (2010)

Taken together, these results suggested that propranolol enhanced the sensitivity of gastric cancer cells to radiation through the inhibition of β-ARs and the downstream NF-κB-VEGF/EGFR/COX-2 pathway.
A statistical framework for genomic data fusion (2004)

Supplementary data at http://noble.gs.washington.edu/proj/sdp-svm
Enhanced Dynamics of HIV gp120 Glycoprotein by Small Molecule Binding (2011)

HIV cell entry and infection are driven by binding events to the CD4 and chemokine receptors with associated conformational change of the viral glycoprotein, gp120. Scyllatoxin miniprotein CD4 mimetics and a small molecule inhibitor of CD4 binding, NBD-556, also effectively induce gp120 conformational change. In this study we examine the fluctuation profile of gp120 in context of CD4, a miniprotein mimetic, and NBD-556 with the aim of understanding the effect of ligand binding on gp120 conformational dynamics. Analysis of molecular dynamics trajectories indicate that NBD-556 binding in the Phe 43 cavity enhances the overall mobility of gp120, especially in the outer domain in comparison to CD4 or miniprotein bound complex. Interactions with the more flexible bridging sheet strengthen upon NBD-556 binding and may contribute to gp120 restructuring. The enhanced mobility of D368, E370, and I371 with NBD-556 bound in the Phe 43 cavity suggests that interactions with α3-helix in the outer domain are not optimal, providing further insights into gp120--small molecule interactions that may impact small molecule designs.
Experimental demonstration of 100nm channel length In<inf>0.53</inf>Ga<inf>0.47</inf>As-based vertical inter-band tunnel field effect transistors (TFETs) for ultra low-power logic and SRAM applications (2009)

Vertical In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.53</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.47</sub> As tunnel field effect transistors (TFETs) with 100nm channel length and high-k/metal gate stack are demonstrated with high I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> ratio (>10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> ). At V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</sub> = 0.75V, a record on-current of 20¿A/¿m is achieved due to higher tunneling rate in narrow tunnel gap In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.53</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.47</sub> As. The TFETs exhibit gate bias dependent NDR characteristics at room temperature under forward bias confirming band to band tunneling. The measured data are in excellent agreement with two-dimensional numerical simulation at all drain biases. A novel 6T TFET SRAM cell using virtual ground assist is demonstrated despite the asymmetric source/drain configuration of TFETs.