gebhart/patrepeval huggingface dataset:
Hyperthermic inactivation, recovery and induced thermotolerance of human natural killer cell lytic function (1991)

Natural killer (NK) cytotoxic activity in human peripheral blood mononuclear cells or preparations of large granular lymphocytes was assayed after a hyperthermia treatment. Human NK cells are very sensitive to hyperthermic inactivation; 30 min at 42 degrees C reduced NK lytic activity toward K562 target cells by 40-50%, 43 degrees C by 85-90% and 44 degrees C or 45 degrees C by 100%, but similar treatment of the target cells did not alter their sensitivity to lysis. However, holding at 37 degrees C allowed heated NK cells to recover their lytic activity. The extent of the recovery was inversely correlated with the temperature as well as the recovery time. Heated and subsequently recovered NK cells were more thermotolerant to loss of lytic function by a further hyperthermia exposure. About 0.65 degrees C increase in temperature was required for a 50% loss of lysis ability in the NK cells made thermotolerant by a previous hyperthermic exposure at 43 degrees C for 30 min. The Vmax for NK lytic activity of cells heated at 42 degrees C for 30 min was reduced by 70% compared with that of normal NK cells. When heated cells were incubated the Vmax recovered. There are at least two heat-sensitive processes involved in NK cytotoxic activity. Cells completely inactivated for target cell lysis by a 44 degrees C exposure still showed recognition and binding functions and acted as competitive inhibitors of unheated NK cells. Cells heated at 45 degrees C caused less inhibition and had lower ability to recognize and bind target cells. The lytic function is therefore a more heat-sensitive process than the recognition and binding functions, but both are heat-inhibitable. Individual variations in thermal sensitivity, recovery and induced thermotolerance were evident.
[Synthesis of multifunctional surfactants for elaboration of micellar model systems of enzymes]. (1998)

In order to provide a closer analogy between micelles and enzymes, the design of functionalized micellar systems have been undertaken. This paper presents the synthesis of surfactant cationic molecules which contains either a free or a protected aldehyde group. An ammonium quaternary surfactant with two functional groups, aldehyde dimethyl acetal and imidazole, has also been synthesized.
Testosterone and Cognition in Normal Aging and Alzheimers Disease: An Update (2007)

There is evidence to suggest that testosterone loss constitutes a risk for cognitive decline and possibly dementia, and that elderly men might benefit from exogenous supplementation of testosterone. Studies in non-human animals repeatedly report neuroexcitatory and neuroprotective properties of testosterone and enhanced memory performance after acute or chronic treatment. Positive effects of testosterone supplementation in older men have been reported in several, but not all, studies and require replication in larger randomized clinical trials before recommendations for clinical practice can be made. The current review summarizes recent studies on the neurobiological connection between testosterone and cognitive function in humans and non-human animals. When appropriate, we use the hippocampus as a model structure given it's involvement in sexually dymorphic spatial ability and sensitivity to both androgens and aging. In addition, a number of potential explanations of the discrepancy between data obtained in humans and non-human animals are discussed.
Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer (2010)

GV1001 is a telomerase-specific, promiscuous class II peptide vaccine which is currently in an advanced stage of clinical development. This article reviews the biological rationale underpinning the design of ongoing studies with the vaccine as well as its immunogenicity and clinical activity. It places GV1001 in the context of other immunotherapeutic approaches targeting telomerase and assesses the chances of the vaccine becoming a future standard of care in the treatment of cancer.
Growth and electrical properties of Al<sub><i>x</i></sub>Ga<sub>1−<i>x</i></sub>N/GaN heterostructures with different Al‐content (2009)

Abstract High electron mobility transistor material and device properties based on Al x Ga 1− x N/GaN heterostructures with an Al‐content ranging from 12 to 35% are presented. The Al‐content of the low pressure metal‐organic vapor‐phase epitaxy grown samples on semi‐insulating SiC and sapphire was measured by high resolution X‐ray diffraction; carrier concentration and mobility by Hall effect. The sheet carrier density in the nominally undoped structures increases with the Al‐content from 3.6 × 10 12 to 1.4 × 10 13 cm −2 due to spontaneous and piezoelectric polarization. Comparison of the electrical data with a model based on polarization and strain induced effects in dependence of the Al‐composition shows good agreement. Further discussion and presentation on devices is restricted to data on SiC substrates. We quantitatively relate threshold voltage and extrinsic transconductance of FETs to the carrier concentration und thus to the Al‐content in the barrier. Excellent large signal performance is achieved over the Al x Ga 1− x N‐composition range from 14 to 30%.
The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish (2011)

Using sapje zebrafish which lack dystrophin, we have assessed both the quantitation of muscle damage in dystrophic fish, and the efficacy of the proteasomal inhibitor MG132 in reducing the dystrophic symptoms. Fourier analysis of birefringence patterns in normal and dystrophic fish was found to be a simple and reliable quantitative measure of muscle damage. MG132, as in mdx mouse, was found to be effective in reducing muscle damage with an EC50 of 0.4µM. This study adds further to the utility of zebrafish as a model of choice for testing muscular dystrophy therapeutics.
Environmental Influences on Minority Degree Attainment (1991)

Findings concerning environmental factors that relate to minority degree achievement in predominantly white four-year colleges and universities are discussed, based on a study sponsored by the National Center for Postsecondary Governance and Finance. The findings are used to suggest adaptations to a Framework for Evaluating Institutional to Minorities: A Guide to Institutional Self-Study, which was developed under the auspices of the American Council of Education. The study was entitled Organizational Influences on Baccalaureate Achievement by Minorities: Ten Case Studies. Successful campus efforts to improve minority degree achievement in a majority of the 10 institutions were: strong programs to help students with academic preparation problems; emphasis on pre-college programs and relations with elementary and secondary schools; emphasis on multicultural environments; successful resolution to the organizational dilemma of separatist versus support programs for minority students; proactive approaches to financial aid; and opportunities for on-campus housing. The following five areas of the institutional self-study framework are addressed: admissions and recruitment; financial aid; counseling, support serT,ices, and placement; curriculum; and environment. The Framework for Evaluating Institutional Commitment is appended and 11 references are included. (SW) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ********k**************************************************************
Magnesium for acute traumatic brain injury (2008)

There is currently no evidence to support the use of magnesium salts in patients with acute traumatic brain injury.
Extending NHC-Catalysis: Coupling Aldehydes with Unconventional Reaction Partners (2011)

Transition metal catalysis is a powerful means of effecting organic reactions, but it has some inherent drawbacks, such as the cost of the catalyst and the toxicity of the metals. Organocatalysis represents an attractive alternative and, in some cases, offers transformations unparalleled in metal catalysis. Unique transformations are a particular hallmark of N-heterocyclic carbene (NHC) organocatalysis, a versatile method for which a number of modes of action are known. The NHC-catalyzed umpolung (that is, the inversion of polarity) of electrophilic aldehydes, through formation of the nucleophilic Breslow intermediate, is probably the most important mode of action. In this Account, we discuss the reaction of Breslow intermediates with unconventional reaction partners. In two traditional umpolung reactions, the benzoin condensation and the Stetter reaction, some selectivity issues represent significant challenges, especially in intermolecular variants of these reactions. In intermolecular cross-benzoin reactions, high levels of selectivity were recently obtained, even in the hydroxymethylation of aldehydes with formaldehyde. The key to success was careful choice of the NHC catalyst and reaction conditions. Among asymmetric Stetter reactions, intermolecular versions have posed a long-standing challenge. Recently, the groups of Enders and Rovis reported the first selective and efficient systems. We have contributed to this field by developing an efficient intermolecular Stetter reaction for the formation of α-amino acid derivatives, with broad aldehyde scope and high enantiomeric excess. Moreover, tailor-made thiazolylidene catalysts allowed the unprecedented use of nonactivated olefins and alkynes as aldehyde coupling partners. The basis for this reactivity is a unique mode of NHC organocatalysis: dual activation. In a concerted but asynchronous transition state, the positively polarized proton of the Breslow intermediate activates the coupling partner (for example, an olefin), while the nucleophilic enamine moiety starts to attack the activated coupling partner. As a consequence of the concerted nature of this mechanism, excellent values for enantiomeric excess were obtained for many substrates in the intramolecular hydroacylation of alkenes. In addition, thiazolylidene catalysts have enabled the coupling of aldehydes with reactive species, for example, with arynes and with activated alkyl bromides. NHC catalysis should continue to flourish and lead to surprising developments. One remaining challenge is the asymmetric intermolecular hydroacylation of unactivated olefins. In this area, metal-based catalysts have shown promising early results, but they are far from being either general or practical. It will be interesting to see which class of catalyst, whether metal-based or NHC-based, eventually develops into the method of choice.
Quantification of Aromaticity of Heterocyclic Systems Using Interaction Coordinates (2018)

Recently, we proposed an aromaticity index based on interaction coordinates (AIBIC) ( J. Phys. Chem. A 2016 , 120 , 2894 - 2901 ). This index works well for the aromatic hydrocarbons. However, in the case of heterocyclic systems, the AIBIC overestimates the aromaticity indicating many of them to be more aromatic than benzene, which seems unlikely. Because of the differences in the electronegativity of the carbon and the other heteroatoms, the electron density is partially localized near the more electronegative atom(s) of the aromatic fragment. This localized electron density does not contribute to the aromaticity that is due to the delocalized electron density over the central ring. To account for this reduction in the delocalized electron density, a correction is introduced based on Pauling's electronegativity equation. When the corrected interaction coordinates are used in the computation of AIBIC, we get a new index-aromaticity index based on interaction coordinates corrected. This new index, when computed for a variety of heterocyclic systems, yields results in line with the expectations, and its usefulness in quantifying aromaticity appears to be very promising.
Autonomous multi-sensor platform with stereo vision (2009)

This paper is describing a different way to investigate the terrain topography: stereo images. This is the closest way of terrain investigation to the human sight. By gathering as much information from images the need for other sensors on the robot will be no more. This is an obvious fact since for human more than 90% of information about the surrounding environment is coming from sight. An equipment to capture and process stereo images had been build and the software was created to prove the accuracy of this method to detect and avoid obstacles and to investigate the terrain topography for uncharted areas. To extract the information needed for the navigation from the stereo optic images, complex algorithms of shape recognisance, pattern mach and cross correlation will be involved together with image calibration and sharpening. Because the processing power requirements will be huge methods to decrease the computation need will be used to increase the processing speed The sensor and control board are build on one PCB. High power digital signal had to been as far as possible from the high accuracy analog inputs. The magnetic compass proves a very high accuracy: 0.5 degrees. For fast movements, the gyroscopes can give better measurement,. The triaxial accelerometer is a poor way to measure movement. It is mainly used as an inclinometer to help the algorithm of the electronic compass. For the measurement of speed and distance, an odometer is used. It is having a very good resolution, few millimeters, but it is insensitive to car sliding and mechanical interconnection imperfection. For these the accelerometer can be used to improve the result. The GPS results are used for less accurate measurements since its accuracy of positioning is around 5-10 m. The information from all sensors is centralized into a powerful MCU. The MCU alone can be used for controlling the robot movement on a simple route. For more complex situations, this acquisition module is connected to a small PC able to conduct more complex data analysis.
Resource Evaluation of Marine Gas Hydrate Deposits Using Seafloor Compliance Methods (2000)

A bstract : We introduce the theory and practice of the compliance method: a new tool for assessing offshore methane hydrate deposits. Compliance is defined as the transfer function between the vertical displacement of the seafloor and the corresponding pressure expressed as a function of frequency. It is sensitive to the elastic parameters of the underlying sediments, particularly the shear modulus. We have measured normalized compliance from 0.001 to 0.049 Hz, using ocean surface gravity waves as a source, at sites in Cascadia near the Ocean Drilling Program (ODP) hole 889B. A differential pressure gauge, datalogger, and self‐leveling gravimeter were lowered to the seafloor, and each site was occupied for eight hours. The compliance estimates are reproducible and are consistent with other available data and simple models of sediment physical properties. Shear strength is increased from a normal profile in the uppermost few hundred meters, possibly an effect of grain cementation within a known hydrate layer. The magnitude of the increase may be associated with the total mass of hydrate present irrespective of the details of its distribution.
ANTIC85: a general purpose finite element package for computer aided design and analysis of electromagnetic devices (1988)

A description is given of ANTIC85, a powerful and user-friendly finite-element-based magnetic field analysis package. This program is used for the design and analysis of electromechanical devices for automotive applications. It is applicable to general two-dimensional and axisymmetric three-dimensional static and transient nonlinear magnetic field problems. The unique feature of this package is its ability to solve the coupled power-electronic, mechanical, and magnetic field problem for solenoid actuators. The theoretical basis and structure of this package are presented. Applications to a four-pole 3 kW permanent-magnet starter motor and a variable-reluctance-type speed sensor are shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Integrated antennas in eWLB packages for 77 GHz and 79 GHz automotive radar sensors (2011)

The feasibility of an antenna-in-package (AiP) concept is demonstrated for automotive radar sensors at the 77 GHz-band. Infineon's embedded wafer level ball grid array (eWLB) is employed as packaging technology. We developed a printed dipole antenna (PDA) and a printed loop antenna (PLA) in 8×8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> eWLB packages that include 3×3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> dummy Si chips. The fabricated eWLB packages are soldered onto evaluation boards that are designed and fabricated on an RF substrate. The measurements and the simulations are in a good agreement and predict a promising solution for the realization of cost efficient antenna-in-package concepts.
The Three Models of Emotional Intelligence and Performance in a Hot and Cool go/no-go Task in Undergraduate Students (2017)

Emotional intelligence (EI), or the ability to perceive, use, understand and regulate emotions, appears to be helpful in the performance of "hot" (i.e., emotionally laden) cognitive tasks when using performance-based ability models, but not when using self-report EI models. The aim of this study is to analyze the relationship between EI (as measured through a performance-based ability test, a self-report mixed test and a self-report ability test) and cognitive control ability during the performance of hot and "cool" (i.e., non-emotionally laden) "go/no-go" tasks. An experimental design was used for this study in which 187 undergraduate students (25% men) with a mean age of 21.93 years (standard deviation [SD] = 3.8) completed the three EI tests of interest (Mayer-Salovey-Caruso Emotional Intelligence Test [MSCEIT], Trait Meta-Mood Scale [TMMS] and Emotional Quotient Inventory-Short Form [EQi:S]) as well as go/no-go tasks using faces and geometric figures as stimuli. The results provide evidence for negative associations between the "managing" branch of EI measured through the performance-based ability test of EI and the cognitive control index of the hot go/no-go task, although similar evidence was not found when using the cool task. Further, the present study failed to observe consistent results when using the self-report EI instruments. These findings are discussed in terms of both the validity and implications of the various EI models.
Secretory peptides TFF1 and TFF3 synthesized in human conjunctival goblet cells. (1999)

Goblet cells of the human conjunctiva synthesize TFF1 and TFF3. These peptides, together with the secretory ocular mucin MUC5AC, may contribute to the rheological properties of the tear film. They also may influence healing of corneal wounds due to their motogenic properties.
Large-Scale Music Annotation and Retrieval: Learning to Rank in Joint Semantic Spaces (2011)

Music prediction tasks range from predicting tags given a song or clip of audio, predicting the name of the artist, or predicting related songs given a song, clip, artist name or tag. That is, we are interested in every semantic relationship between the different musical concepts in our database. In realistically sized databases, the number of songs is measured in the hundreds of thousands or more, and the number of artists in the tens of thousands or more, providing a considerable challenge to standard machine learning techniques. In this work, we propose a method that scales to such datasets which attempts to capture the semantic similarities between the database items by modeling audio, artist names, and tags in a single low-dimensional semantic space. This choice of space is learnt by optimizing the set of prediction tasks of interest jointly using multi-task learning. Our method both outperforms baseline methods and, in comparison to them, is faster and consumes less memory. We then demonstrate how our method learns an interpretable model, where the semantic space captures well the similarities of interest.
Optimal trauma resuscitation with plasma as the primary resuscitative fluid: the surgeon's perspective (2013)

Over the past century, blood banking and transfusion practices have moved from whole blood therapy to components. In trauma patients, the shift to component therapy was achieved without clinically validating which patients needed which blood products. Over the past 4 decades, this lack of clinical validation has led to uncertainty on how to optimally use blood products and has likely resulted in both overuse and underuse in injured patients. However, recent data from both US military operations and civilian trauma centers have shown a survival advantage with a balanced transfusion ratio of RBCs, plasma, and platelets. This has been extended to include the prehospital arena, where thawed plasma, RBCs, and antifibrinolytics are becoming more widely used. The Texas Trauma Institute in Houston has followed this progression by putting RBCs and thawed plasma in the emergency department and liquid plasma and RBCs on helicopters, transfusing platelets earlier, and using thromboelastogram-guided approaches. These changes have not only resulted in improved outcomes, but have also decreased inflammatory complications, operations, and overall use of blood products. In addition, studies have shown that resuscitating with plasma (instead of crystalloid) repairs the "endotheliopathy of trauma," or the systemic endothelial injury and dysfunction that lead to coagulation disturbances and inflammation. Data from the Trauma Outcomes Group, the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study, and the ongoing Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial represent a decade-long effort to programmatically determine optimal resuscitation practices, balancing risk versus benefits. With injury as the leading cause of death in patients age 1 to 44 years and hemorrhage the leading cause of potentially preventable death in this group, high-quality data must be obtained to provide superior care to the civilian and combat injured.
Environmentalists ired by California decision (1987)

RETURN TO ISSUEPREVNewsNEXTEnvironmentalists ired by California decisionRUDY BAUMCite this: Chem. Eng. News 1987, 65, 11, 22Publication Date (Print):March 16, 1987Publication History Published online8 November 2010Published inissue 16 March 1987https://pubs.acs.org/doi/10.1021/cen-v065n011.p022https://doi.org/10.1021/cen-v065n011.p022newsACS PublicationsCopyright © 1987 American Chemical SocietyArticle Views7Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Drinking water,Natural resources,Toxicology Get e-Alerts