gebhart/patrepeval huggingface dataset:
The features of temporal focusing multiphoton excitation fluorescence microscopy using the different excitation wavelength (Conference Presentation) (2019)

Temporal focusing multiphoton excitation microscopy (TFMPEM) is insufficient to perform efficient excitation of fluorophores with the different two-photon absorption spectra in the multi fluorophores imaging via an illuminated configuration of fixed wavelength and polarization direction of the pulse laser because of the a diffraction device. In this study, we overcome and causes it is not useful for in the practical application and its development. In order to implement the temporal focusing microscope system could be able to sever for the different excitation wavelength range of 700-1000 nm, we work on the optical design of the temporal focusing an integration stage and scanning mirror with automatic tuning system for any excitation wavelength. The novel TFMPEM has successfully provided dynamic spectral absorption, 3D two-photon or SHG images with the original ability of the high frame rate.
Selective inhibition of butyrylcholinesterase by singlet oxygen-generated melatonin derivatives (2010)

The inhibition of cholinesterases plays a crucial role in a therapy of neurodegenerative diseases, including Alzheimer's disease. Especially, butyrylcholinesterase (BChE) has recently gained special interest. On the other hand, compounds having antioxidative properties may have a beneficial role in slowing down neurodegeneration processes. To combine these two effects, we synthesized a series of new derivatives of melatonin, which is a strong antioxidant, possessing structural elements essential for the inhibitory activity against cholinesterase. The structure of the new compounds was confirmed by NMR spectroscopy and mass spectrometry, and their activity against cholinesterases was measured in vitro using modified Ellman's method. The compounds obtained showed a high inhibitory activity, together with a strong selectivity against BChE. These results may point at new area of interest in a research on cholinesterase inhibitors.
Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis (2016)

The ClpP protease complex and its regulatory ATPases, ClpC1 and ClpX, inMycobacterium tuberculosis(Mtb) are essential and, therefore, promising drug targets. TheMtbClpP protease consists of two heptameric rings, one composed of ClpP1 and the other of ClpP2 subunits. Formation of the enzymatically active ClpP1P2 complex requires binding of N-blocked dipeptide activators. We have found a new potent activator, benzoyl-leucine-leucine (Bz-LL), that binds with higher affinity and promotes 3-4-fold higher peptidase activity than previous activators. Bz-LL-activated ClpP1P2 specifically stimulates the ATPase activity ofMtbClpC1 and ClpX. The ClpC1P1P2 and ClpXP1P2 complexes exhibit 2-3-fold enhanced ATPase activity, peptide cleavage, and ATP-dependent protein degradation. The crystal structure of ClpP1P2 with bound Bz-LL was determined at a resolution of 3.07 Å and with benzyloxycarbonyl-Leu-Leu (Z-LL) bound at 2.9 Å. Bz-LL was present in all 14 active sites, whereas Z-LL density was not resolved. Surprisingly, Bz-LL adopts opposite orientations in ClpP1 and ClpP2. In ClpP1, Bz-LL binds with the C-terminal leucine side chain in the S1 pocket. One C-terminal oxygen is close to the catalytic serine, whereas the other contacts backbone amides in the oxyanion hole. In ClpP2, Bz-LL binds with the benzoyl group in the S1 pocket, and the peptide hydrogen bonded between parallel β-strands. The ClpP2 axial loops are extended, forming an open axial channel as has been observed with bound ADEP antibiotics. Thus occupancy of the active sites of ClpP allosterically alters sites on the surfaces thereby affecting the association of ClpP1 and ClpP2 rings, interactions with regulatory ATPases, and entry of protein substrates.
Method and apparatus for speech recognition using both low-order and high-order parameter analyzation (1995)

First Page
FORMATION OF WHEY PROTEIN POLYMERS: EFFECTS OF A TWO‐STEP HEATING PROCESS ON RHEOLOGICAL PROPERTIES (1999)

ABSTRACT Whey protein polymers were obtained by two‐step heating of whey protein isolate (WPI) solutions with or without change of pH or protein concentration. Rheological properties of polymer solutions were studied. Viscosity of solutions heated then diluted was about 6 times higher than viscosity of equal concentration solutions heated directly. A second heating at a lower pH resulted in higher viscosity. Solutions were generally thixotropic and pseudoplastic; however, dilatant and rheopectic behavior was also observed. A 4% WPI solution could be converted to a polymer solution with a viscosity comparable to the viscosity of 1% carbohydrate hydrocolloids.
A Trifunctional Catalyst for the Synthesis of Chiral Diols (2001)

A transition metal based biomimic approach is used to realize multistep reactions, composed of multicomponent systems, in a single-pot synthesis of chiral diols mediated by a trifunctional (Pd, Os, W) catalyst anchored to a single matrix (see scheme; LDH=layered double hydroxide, (DHQD)2PHAL=1,4-bis(9-O-dihydroquinidinyl)phthalazine, NMM=N-methylmorpholine).
<title>Joint transform correlator using a 4-f lens system to achieve virtual displacement along the optical axis</title> (1993)

The performance of the optical joint transform correlator is severely degraded when multiple targets or multiple identical nontarget images in the input plane produce false peaks in the output plane. One method for overcoming this is to displace the input and or reference plane along the optical axis. This results in the true correlation peaks coming to a focus in an output plane separate from the plane where the false peaks come into focus. These planes are also separated by displacement along the optical axis. We show that this separation can be achieved by placing a simple lens system along one side of the optical path in the input side of a conventional joint transform correlator. By appropriate lens choice, any virtual displacement can be achieved. Through use of computer simulation, we show the effects of varying the virtual input displacement.
Soundproofing woody flooring (1993)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Shiro Kawaguchi, Katsunori Kai; Soundproofing woody flooring. J. Acoust. Soc. Am. 1 January 1993; 93 (1): 591. https://doi.org/10.1121/1.405571 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Analysis of thin rod flexural acoustic wave gravimetric sensors (1990)

An analysis of thin rod flexural acoustic wave gravimetric sensors is presented. The diameter of the thin rod is much less than a wavelength. The lowest order flexural acoustics mode, F11, is of interest. For small added masses, the calculated mass sensitivity is −1/(2ρa), where ρ is the density and a is the radius of the thin rod. Measurements of velocity dispersion of the F11 mode in 21-μm-diam gold wires are shown to agree well with the theoretical calculation. Devices based on thin rods are shown to potentially have the same advantages as plate-mode gravimetric sensors.
Efficient decomposition of single-qubit gates into<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>V</mml:mi></mml:math>basis circuits (2013)

We develop efficient algorithms for compiling single-qubit unitary gates into circuits over the universal $V$ basis. The $V$ basis is an alternative universal basis to the more commonly studied basis consisting of Hadamard and $\ensuremath{\pi}/8$ gates. We propose two classical algorithms for quantum circuit compilation: the first algorithm has expected polynomial time [in precision $\mathrm{log}(1/\ensuremath{\epsilon})$] and produces an $\ensuremath{\epsilon}$ approximation to a single-qubit unitary with a circuit depth $\ensuremath{\le}12\phantom{\rule{0.16em}{0ex}}{\mathrm{log}}_{5}(2/\ensuremath{\epsilon})$. The second algorithm performs optimized direct search and yields circuits a factor of 3 to 4 times shorter than our first algorithm, but requires time exponential in $\mathrm{log}(1/\ensuremath{\epsilon})$; however, we show that in practice the runtime is reasonable for an important range of target precisions. Decomposing into the $V$ basis may offer advantages when considering the fault-tolerant implementation of quantum circuits.
Symmetry of differential optical responses of normal and superconducting phases in single-crystal YBCO (1995)

We measured differential optical reflectivity (DOR) of YBCO single domains. DOR measurements reject the temperature independent bulk reflectivity and reveal dRdT. These measurements detect the superconducting transition, and reveal specific anisotropy associated with high-Tc superconductivity.
Client-Driven Joint Cache Management and Rate Adaptation for Dynamic Adaptive Streaming over HTTP (2013)

Due to the fact that proxy-driven proxy cache management and the client-driven streaming solution of Dynamic Adaptive Streaming over HTTP (DASH) are two independent processes, some difficulties and challenges arise in media data management at the proxy cache and rate adaptation at the DASH client. This paper presents a novel client-driven joint proxy cache management and DASH rate adaptation method, named CLICRA, which moves prefetching intelligence from the proxy cache to the client. Based on the philosophy of CLICRA, this paper proposes a rate adaptation algorithm, which selects bitrates for the next media segments to be requested by using the predicted buffered media time in the client. CLICRA is realized by conveying information on the segments that are likely to be fetched subsequently to the proxy cache so that it can use the information for prefetching. Simulation results show that the proposed method outperforms the conventional segment-fetch-time-based rate adaptation and the proxy-driven proxy cache management significantly not only in streaming quality at the client but also in bandwidth and storage usage in proxy caches.
Cooperation vs. multiplexing (2010)

With the next generation cellular networks making a transition towards smaller cells, two-hop OFDMA relay networks have become a dominant, mandatory component in the 4G standards (WiMAX 802.16j, 3GPP LTE-Adv). While unicast flows have received reasonable attention in two-hop OFDMA relay networks, not much light has been shed on the design of efficient scheduling algorithms for multicast flows, thereby forming the focus of this work. We show that while relay cooperation is critical for improving multicast performance, it must be carefully balanced with the ability to multiplex multicast sessions and hence maximize aggregate multicast flow. To this end, we highlight strategies that carefully group relays for cooperation to achieve this balance. We then solve the multicast scheduling problem under two OFDMA sub-channelization models. We establish the NP-hardness of the scheduling problem even for the simpler model and provide efficient algorithms with approximation guarantees under both models. Evaluation of the proposed solutions reveals the efficiency of the scheduling algorithms as well as the significant benefits obtained from the multicasting strategy.
CMOS IC Diagnostics Using the Light Emission from Off-State Leakage Currents (LEOSLC) (2005)

Abstract Off-state leakage currents account for roughly half of the total current is today’s ICs, and with each new generation of technology, the problem is getting worse. Failure analysts, however, see things differently. Light emission associated with leakage current is a rich source of information about the operation of ICs. In this article, the authors explain how they use this light to monitor logic states, measure temperatures, analyze cross-talk and power distribution noise, and diagnose broken scan chains. Light emission from off-state leakage current (LEOSLC) is shown to be especially useful for diagnosing faults that reside in scan clock trees, which are otherwise very difficult to detect.
Platinum-Coated Copper Nanowires with High Activity for Hydrogen Oxidation Reaction in Base (2013)

Platinum (Pt)-coated copper (Cu) nanowires (Pt/CuNWs) are synthesized by the partial galvanic displacement of CuNWs and have a 100 nm diameter and are 25-40 μm length. Pt/CuNWs are studied as a hydrogen oxidation reaction (HOR) catalyst in base along with Cu templated Pt nanotubes (PtNT (Cu)), a 5% Cu monolayer on a bulk polycrystalline Pt electrode (5% ML Cu/BPPt), BPPt, and carbon supported Pt (Pt/C). Comparison of these catalysts demonstrates that the inclusion of Cu benefited the HOR activity of Pt/CuNWs likely by providing compressive strain on Pt; surface Cu further aids in hydroxyl adsorption, thereby improving the HOR activity of Pt/CuNWs. Pt/CuNWs exceed the area and mass exchange current densities of carbon supported Pt by 3.5 times and 1.9 times.
Oxidative detoxification of phosphonothiolates (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative detoxification of phosphonothiolatesYu Chu Yang, Linda L. Szafraniec, William T. Beaudry, and Dennis K. RohrbaughCite this: J. Am. Chem. Soc. 1990, 112, 18, 6621–6627Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://doi.org/10.1021/ja00174a025RIGHTS & PERMISSIONSArticle Views939Altmetric-Citations126LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (894 KB) Get e-Alerts Get e-Alerts
A new approach to hand-based authentication (2007)

Hand-based authentication is a key biometric technology with a wide range of potential applications both in industry and government. Traditionally, hand-based authentication is performed by extracting information from the whole hand. To account for hand and finger motion, guidance pegs are employed to fix the position and orientation of the hand. In this paper, we consider a component-based approach to hand-based verification. Our objective is to investigate the discrimination power of different parts of the hand in order to develop a simpler, faster, and possibly more accurate and robust verification system. Specifically, we propose a new approach which decomposes the hand in different regions, corresponding to the fingers and the back of the palm, and performs verification using information from certain parts of the hand only. Our approach operates on 2D images acquired by placing the hand on a flat lighting table. Using a part-based representation of the hand allows the system to compensate for hand and finger motion without using any guidance pegs. To decompose the hand in different regions, we use a robust methodology based on morphological operators which does not require detecting any landmark points on the hand. To capture the geometry of the back of the palm and the fingers in suffcient detail, we employ high-order Zernike moments which are computed using an effcient methodology. The proposed approach has been evaluated on a database of 100 subjects with 10 images per subject, illustrating promising performance. Comparisons with related approaches using the whole hand for verification illustrate the superiority of the proposed approach. Moreover, qualitative comparisons with state-of-the-art approaches indicate that the proposed approach has comparable or better performance.
374. Therapeutic Effect of Platelet Transfusions for Acute Neuronopathic Gaucher Disease (2015)

Enzyme replacement therapy has led to resolution of most visceral manifestations in Gaucher disease (GD), but it is also limited by the instability of acid beta -glucosidase enzyme (GCase) in circulation, liver 1st bypass, and high cost. In addition, intravenous enzyme administration has not been effective for ameliorating central nervous system (CNS) deficits. Platelets are blood elements that contain cytoplasmic secretory vesicles. The involvement of platelet containing proteins in inflammation and angiogenesis has recently been indicated. We have recently shown that platelets/megakaryocytes could serve as efficient and protective depots for lysosomal enzyme generation and distribution. In this study the potential therapeutic benefits of platelet transfusion in treating neuronopathic GD (nGD) was evaluated using a murine model of acute nGD (4L;C). This model resembles the CNS phenotype and biochemistry of types 2 and 3 Gaucher disease, and premature death results from progressive CNS disease. Platelets containing significant amounts of wild type GCase (19 U/109 plt) were isolated from GFP mice and transfused weekly for four times into 4L;C mice beginning at 21 days of age. The average percentages of donor-derived platelets were at mean of 10% to 12.9% (ranging from 7.2 to 16.1%) as measured one hour after each transfusion by flow cytometry analysis with anti-CD41 staining for GFP-positive donor platelets. Clearance curves of transfused platelets were similar in 4L;C and wild-type recipients with comparable half-life of GFP+ platelets (t1/2=50 h), suggesting the lack of an immune-response against platelet-derived normal GCase in nGD mice. Importantly, the life-span of treated 4L;C mice was significantly extended from 46 days [untreated 4L;C (n=22)] to 54 days [treated, (n=7)]. Potential CNS benefits were assessed using hindlimb gait analysis that evaluated motor function. In comparison to normal controls, the untreated 4L;C mice exhibited abnormal splaying of their hindlimbs and progressive paresis. The platelet-treated 4L;C mice improved significantly toward normal behavior and had delays in the age of onset for CNS signs. Immunohistochemistry analysis showed that numbers of CD68+ cells were decreased in the cerebellum, brainstem and cortex of treated 4L;C mice, indicating the reduction of pro-inflammation by platelet transfusion. The clearance of GFP+ platelets by liver and spleen was shown by GFP signals detected in those organs of treated 4L;C mice. Quantification of the pathogenic lipids, glucosylceramide and glucosylsphingosine, is in progress to assess potential metabolic correction in various regions of brain and visceral organs in platelet-treated nGD mice. More studies are underway to further investigate possible mechanism(s) involved. In summary, our results demonstrate that repeated, moderate levels of platelet transfusion could extend the life span of nGD mice and improve CNS deficits. abbbb
A 1.02nW PMOS-only, trim-free current reference with 282ppm/°C from −40°C to 120°C and 1.6% within-wafer inaccuracy (2017)

A 1.02nW current reference is designed with only PMOS transistors, thereby providing inherently low process variation and enabling trim-free operation. Thirty-two measured chips from 5 corner wafers in 180nm CMOS technology show an untrimmed within-wafer spread (σ/μ) of 1.6% and across-corner wafer-to-wafer spread of ±4.7%. The measured average temperature coefficient is 282ppm/°C from -40°C to 120°C while generating a 35nA reference current. Total untrimmed uncertainty due to variations of process, voltage, and temperature is about 8.8%.
Simulation of a carbon nanotube-based compliant parallel-guiding mechanism: A nanomechanical building block (2006)

The authors report the behavior of a nanoscale parallel-guiding mechanism wherein the compliant components are single-walled carbon nanotubes. Parallel-guiding mechanisms are often the building blocks of macro- and microscale mechanical systems. The authors present results that provide insight into the performance of a parallel-guiding mechanism for nanoscale devices. The device exhibits a range over 75% of the device size, i.e., 5.5nm, when actuated with 6.4nN. Below 3.6nN, displacements are due to bulk elastic bending of the nanotubes. Above 5.2nN, displacements are governed by the hingelike bending of kinks in the nanotubes. van der Waals forces are shown to cause direction-dependent behavior.
Viscosity Measurement in Injection Molding Using a Multivariate Sensor (2012)

Online measurement of polymer melt properties during an injection molding process is a key to provide a high quality plastic product. In-situ cavity pressure and temperature sensors are used to observe the polymer states in the mold cavity during an injecting molding process. A new multivariate sensor is introduced to measure pressure, temperature, velocity, and viscosity of polymer melt as the key parameters of the melt to improve the controlling process. This paper presents the viscosity calculating method based on melt velocity and the slope of melt pressure. The velocity is inferred using the melt temperature ramping rate; the new multivariate sensor detects melt temperature through the installed IR detector in the sensor, and the pressure is measured via the mounted piezoelectric rings. Injecting molding process of polymer melt is simulated under a range of melt velocity and temperature and the related viscosity values are inferred from simulation results and also from a set of experimental tests for a real injection molding process. Results are well matched with the expected rheological behavior of polymer.
Evaluation of an image‐guided, robotically positioned transcranial magnetic stimulation system (2004)

The emergence of transcranial magnetic stimulation (TMS) as a tool for investigating the brain has been remarkable over the past decade. While many centers are now using TMS, little has been done to automate the delivery of planned TMS stimulation for research and/or clinical use. We report on an image-guided robotically positioned TMS system (irTMS) developed for this purpose. Stimulation sites are selected from functional images overlaid onto anatomical MR images, and the system calculates a treatment plan and robotically positions the TMS coil following that plan. A new theory, stating that cortical response to TMS is highest when the induced E-field is oriented parallel to cortical columns, is used by the irTMS system for planning the position and orientation of the TMS coil. This automated approach to TMS planning and delivery provides a consistent and optimized method for TMS stimulation of cortical regions of the brain. We evaluated the positional accuracy and utility of the irTMS system with a B-shaped TMS coil. Treatment plans were evaluated for sites widely distributed about a head phantom with well-defined landmarks. The overall accuracy in positioning the planned site of the TMS coil was approximately 2 mm, similar to that reported for the robot alone. The estimated maximum range of error in planned vs. delivered E-field strength was +4%, suggesting a high degree of accuracy and reproducibility in the planned use of the irTMS system.