gebhart/patrepeval huggingface dataset:
Chronic Q Fever (1976)

Sixteen cases of chronic Q fever are described. In eight there was a history of exposure to infection from farms or farm products. All had valvular heart disease, involving the mitral valve in nine and the aortic valve in seven. Infection occurred on a prosthetic valve in two patients. Arterial embolism was common. Venous thrombosis occured in three patients, and pulmonary embolism occurred in three other patients. Complement fixing antibodies to phase 1 antigen were found in a titre of 1:200 or greater in all except two patients. In one of these post-mortem examination revealed rickettsial bodies in mitral valve vegetations, and in the other Coxiella burneti was isolated from heart valve tissue. The majority presented with infective endocarditis but two presented primarily with liver disease. All patients had evidence of liver involvement and in one this led to death from cirrhosis. Abnormal tests of liver function, particularly hyperglobulinaemia, raised alkaline phsophatase and abnormal bromsulphthalein retention were found in all patients. Hepatic histology was abnormal in all eight patients in whom it was studied. The commonest features were mononuclear cell infiltration of the portal tracts and prominence of the sinusoidal Kupffer cells. Patchy focal necrosis of parenchymal cells, granulomata, fatty change, and eosinophilia of the sinusoidal walls were also noted in several patients and cirrhosis developed in one. Six patients had a purpuric rash, and in 12 there was thrombocytopenia. It is suggested that the presence of hepatomegaly and liver involvement and thrombocytopenia may help to differentiate Q fever endocarditis from bacterial endocarditis. Raised serum IgM and IgA levels occured frequently, but with only a moderate dominance of IgM. Sheep cell agglutination and latex fixation tests for rheumatoid factor were occasionally positive. Several features of the disease suggest the possibility that immune-complex mechanisms may play a role in chronic Q fever. Treatment was with prolonged courses of tetracycline usually combined with lincomycin. Seven patients underwent valve replacement surgery for haemodynamic reasons. Five patients died; two from heart failure, one from cirrhosis, one seven days after valve replacement and one from intraperitoneal haemorrhage following percutaneous liver biopsy. Three patients have survived for more than five years, and another six for more than three and a half years after diagnosis. Of these nine patients, three received medical therapy alone and six required valve replacement as well. Antibiotics have been discontinued in four patients who have had valve surgery and three others. Six patients had received antibiotics for continuous periods varying from 29-62 months. In the period after stopping therapy varying from 15-21 months, no relapse has occured. A seventh patient, who had received antibiotics for four months prior to valve replacement, has survived 43 months after the withdrawal of antibiotics...
Neurologic Abnormalities of Lyme Disease (1979)

REIK, LOUIS M.D.; STEERE, ALLEN C. M.D.; BARTENHAGEN, NICHOLAS H. M.D.; SHOPE, ROBERT E. M.D.; MALAWISTA, STEPHEN E. M.D. Author Information
Efficacy and safety of tildrakizumab in patients with active psoriatic arthritis: results of a randomised, double-blind, placebo-controlled, multiple-dose, 52-week phase IIb study (2021)

Tildrakizumab treatment significantly improved joint and skin manifestations of PsA other than dactylitis and enthesitis. Treatment was generally well tolerated through W52. Clinicaltrials.gov NCT02980692.
Insulin-Like Growth Factor Receptors (1991)

Competitive binding experiments from a number of laboratories showed that IGF receptors are distinct from insulin receptors, and that there are two types of IGF receptors based on their relative affinities for IGF-I and IGF-II and whether or not they bind insulin (reviewed in Rechler and Nissley, 1985). Later, affinity crosslinking experiments provided a physical basis for the two IGF receptor subtypes. The receptor which preferred IGF-II over IGF-I and did not bind insulin, was a large 250 kDa species with no apparent subunit structure (Fig. 1). The receptor which prefered IGF-I over IGF-II and bound insulin with low affinity had a binding sub-unit of 130 kDa after reduction of disulfide bonds. Biosynthetic labeling experiments demonstrated a 95 kDa beta subunit addition to the 130 kDa alpha subunit (Fig. 1). The heterotetrameric IGF-I receptor (a,& was therefore very similar to the insulin receptor, and the case for similarity was increased when the beta subunit was found to be auto-phosphorylated in response to IGF-I. Molecular cloning of the IGF-I receptor confirmed that the IGF-I receptor and the insulin receptor areclosely related structures (Ullrich et al., 1986).
Intracystic lipidic profile in fibrocystic breast disease (1994)

This study was designed to investigate the lipidic profile of fibrocystic breast disease. The study entailed measuring total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and triglyceride levels in the serum of 50 women with fibrocystic breast disease without macrocysts, and in the serum and breast cyst fluid of 60 women with fibrocystic breast disease and macrocysts. The relationships between the lipids analyzed in the cyst fluid and intracystic estradiol, progesterone, dehydroepiandrosterone sulfate, testosterone and 17 alpha-hydroxyprogesterone were studied. No differences were found for serum lipid levels between the two groups of patients. The levels of total cholesterol and HDL-C were found to be significantly higher, and the levels of triglycerides and VLDL-C significantly lower in breast cyst fluid compared to serum. In cysts with high potassium concentrations, we found a higher concentration of cholesterol and HDL-C and a lower concentration of LDL-C than in cysts with a potassium/sodium ratio < 3. No significant differences were found in cystic levels of triglycerides and VLDL-C. Multiple regression analysis showed that the only intracystic variable, which was, in part, positively responsible for the hormone levels measured, was HDL-C. These data suggest that local steroidogenesis in fibrocystic breast disease uses HDL-C as the substrate.
Orthosteric muscarinic receptor activation by the insect repellent IR3535 opens new prospects in insecticide-based vector control (2020)

The insect repellent IR3535 is one of the important alternative in the fight against mosquito-borne disease such as malaria, dengue, chikungunya, yellow fever and Zika. Using a multidisciplinary approach, we propose the development of an innovative insecticide-based vector control strategy using an unexplored property of IR3535. We have demonstrated that in insect neurosecretory cells, very low concentration of IR3535 induces intracellular calcium rise through cellular mechanisms involving orthosteric/allosteric sites of the M1-muscarinic receptor subtype, G protein βγ subunits, background potassium channel inhibition generating depolarization, which induces voltage-gated calcium channel activation. The resulting internal calcium concentration elevation increases nicotinic receptor sensitivity to the neonicotinoid insecticide thiacloprid. The synergistic interaction between IR3535 and thiacloprid contributes to significantly increase the efficacy of the treatment while reducing concentrations. In this context, IR3535, used as a synergistic agent, seems to promise a new approach in the optimization of the integrated vector management for vector control.
Transpiration Stream of Desert Species: Resistances and Capacitances for a C<sub>3</sub>, a C<sub>4</sub>, and a CAM Plant (1983)

Transpiration rates and water potentials of three sympatric desert perennials, a C3 subshrub (Encelia farinosa), a C4 bunchgrass (Hilaria rigida), and a CAM succulent (Agave deserti), were analysed using an electrical circuit analogue that included resistances and capacitances for the leaves, stems, and roots. The water storage capability of the organs differed considerably, capacitance ranging over 1000-fold from the thin leaves of H, rigida to the massive leaves of A. deserti, although the capacitance per unit volume varied only 1.9-fold. The diurnal changes in water storage could support maximum transpiration rates of H. rigida for 4 min, E. farinosa for 7 min, and A. deserti for 16 h. The time constant for equilibration of water from storage to the xylem ranged from 29 s for roots of H. rigida to 52 min for leaves of A. deserti. Resistances for such movement were relatively low for the succulent leaves of A. deserti and were up to about 50-fold higher for the three organs of E. farinosa. Xylem resistances calculated using the Hagen-Poiseuille law and measured xylem dimensions were 2.1- to 2.1-fold lower than resistances estimated from observed water potential drops, a discrepancy which is in agreement with other published data. Contrary to data on other plants, the xylem resistances in the roots and leaves of E. farinosa and H. rigida averaged only 15% of the stem xylem resistance.
The Cluster Hypothesis Revisited (2017)

A new means of evaluating the cluster hypothesis is introduced and the results of such an evaluation are presented for four collections. The results of retrieval experiments comparing a sequential search, a cluster-based search, and a search of the clustered collection in which individual documents are scored against the query are also presented. These results indicate that while the absolute performance of a search on a particular collection is dependent on the palrwise similarity of the relevant documents, the relative effectiveness of clustered retrieval versus sequential retrieval is independent of this factor. However, retrieval of entire clusters in response to a query usually results in a poorer performance than retrieval of individual documents from clusters.
Desensitization in HLA-Incompatible Kidney Recipients and Survival (2011)

Live-donor transplantation after desensitization provided a significant survival benefit for patients with HLA sensitization, as compared with waiting for a compatible organ. By 8 years, this survival advantage more than doubled. These data provide evidence that desensitization protocols may help overcome incompatibility barriers in live-donor renal transplantation. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and the Charles T. Bauer Foundation.).
A single-stage high gain current source inverter for grid-connected photovoltaic system (2015)

The output voltage range of PV cells is widely influenced by the environment factors, such as temperature, solar radiation, etc. The lower output voltage of solar array can hardly meet the requirements for grid-connected operation of the system. To achieve high voltage gain and a steady ac output voltage in spite of the low dc input voltage, this paper presents a novel single-stage high gain current source inverter (CSI). The topology of the proposed inverter is derived from conventional tri-state current source inverter by introducing an impedance network with two symmetrical inductors and diodes separately. Theoretical analysis of operation modes and high voltage gain performance for the proposed inverter is presented, followed by the simulation of the proposed inverter in grid-connected photovoltaic (PV) system carried out on MATLAB.
A transient liquid crystal thermography technique for gas turbine heat transfer measurements (2000)

This paper presents in detail the transient liquid crystal technique for convective heat transfer measurements. A historical perspective on the active development of liquid crystal techniques for convective heat transfer measurement is also presented. The experimental technique involves using a thermochromic liquid crystal coating on the test surface. The colour change time of the coating at every pixel location on the heat transfer surface during a transient test is measured using an image processing system. The heat transfer coefficients are calculated from the measured time responses of these thermochromic coatings. This technique has been used for turbine blade internal coolant passage heat transfer measurements as well as turbine blade film cooling heat transfer measurements. Results can be obtained on complex geometry surfaces if visually accessible. Some heat transfer results for experiments with jet impingement, internal cooling channels with ribs, flow over simulated TBC spallation, flat plate film cooling, cylindrical leading edge and turbine blade film cooling are presented for demonstration.
Dermal Immune System (2019)

This text discusses the structural and functional characterizations of the dermal immune system, including dermal dendritic cells, monocyte/macrophages, microvascular endothelial cells, pericytes, veil cells, fibroblasts, mast cells, dermal T lymphocytes and peripheral nerve endings. This information is useful for gaining an understanding of how multicellular complex networks interface within the dermis and between the exogenous environment and endogenous milieu. Specific examples are provided that document the involvement of the dermal immune system in the pathophysiology of several skin diseases that result from perturbation of normal cutaneous homeostasis.
The effect of citric acid and fibronectin application on healing following surgical treatment of naturally occurring periodontal disease in beagle dogs* (1985)

It has recently been suggested that following the exposure of root surface collagen with citric acid, the addition of topically applied fibronectin might promote healing with a fibrous re-attachment. The purpose of this study was to determine the benefit of citric acid demineralization and fibronectin application in the surgical treatment of severe, naturally occurring periodontal disease in Beagle dogs. The 4 treatment modalities employed were: (1) surgery alone (mucoperiosteal flaps); (2) surgery plus fibronectin; (3) surgery plus citric acid; (4) surgery plus citric acid followed by fibronectin application. Coronal and root surface notches were used as biometric and histometric reference points. Final clinical measurements were recorded 6 weeks post surgically, on the day of sacrifice. Significantly increased amounts of connective tissue reattachment were observed in the areas treated with the citric acid/fibronectin combination. Fibrous re-attachment was enhanced at the expense of epithelial downgrowth and occurred directly to both new and old cementum and exposed dentin, often in a functional manner, i.e., perpendicular to the root surface. Areas treated with the surgery and citric acid technique attained moderate amounts of fibrous re-attachment while the other treatment modalities were associated with a long junctional epithelium. The enhanced fibrous re-attachment may be the product of an accelerated coalescing of exposed soft tissue and root surface collagen fibrils, while under the mediating effect of fibronectin.
Oncomirnas and Tumor Suppressors In Microvesicles From Four Types Of Cancer (2013)

Abstract Objectives Microvesicles (MVs) are small vesicles that are shed from almost all cell types including cancer cells into their surroundings. These secreted MVs bear surface receptors/ligands and miRNA of the original cells and play a role in cancer. Our aim in this study was to identify MVs miRNAs that might play important roles both in solid and non-solid tumors. Methods The MVs miRNA expression from 4 kinds of cancer cell lines (SMMC-7721, K562, Nalm6 and Jurkat) and healthy peripheral blood cells were analyzed by miRNA microarray. Quantitative real-time polymerase chain reaction (qRT-PCR) was further performed to verify the expression of 4 dysregulated miRNAs. Results The miRNA microarray revealed aberrantly expressed miRNAs of MVs between the four types of cancer cells and normal cells. In the MVs from cancer groups, 73 miRNAs were up-regulated and 148 were down-regulated in all the four types of cancer cell lines, indicating that solid and non-solid tumors shared some dysregulated MVs miRNAs. qRT-PCR verified statistically consistent expression of four selected miRNAs with microarray analysis. The top six shared upregulated MVs miRNAs in the four cancer cells lines were miR-1290, miR-1268, miR-1246, miR-125a-3p, miR-1305, miR-1226*. The top seven shared downregulated MVs miRNAs in the four cancer cells lines were miR-335, miR-1, miR-363, miR-122, miR-223, miR-338-3p and miR-340. The general roles of the upregulated MVs miRNAs were oncomiRNAs in multicancer. MiR-1290 and its potential targets are associated with characteristics of estrogen receptor α-positive breast cancer. Up-regulations of miR-1290 impaired cytokinesis and affected the reprogramming of colon cancer cells. miR-1246 might serve as a likely link of the p53 family with Down syndrome and proposed a new p53-miR-1246-DYRK1A-NFAT pathway in cancer. The functional roles of the downregulated MVs miRNAs were tumor suppressors in many kinds of cancer. MiR-335 acted as a candidate tumor suppressor and inhibited tumor reinitiation and represented an invasion suppressor gene by targeting Bcl-w in many kinds of cancer. HBx regulated miR-338-3p in HCC and miR-338-3p inhibited proliferation by regulating CyclinD1, and miR-338-3p suppressed the invasion of liver cancer cell by targeting smoothened gene in liver cancer. miR-340 inhibited of breast cancer cell migrations and invasions through targeting of oncoprotein c-Met and may play an important role in breast cancer progression. Conclusion Our study identifies oncomiRNAs and tumor suppressors in MVs from four types of cancer. These MVs miRNAs may contribute to the developments of solid and non-solid tumors and should be further evaluated as a novel biomarker for cancers and may provide potential targets for novel therapeutic strategies. Disclosures: No relevant conflicts of interest to declare.
Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines (2020)

messenger RNA (mRNA)-based vaccines combine the positive attributes of both live-attenuated and subunit vaccines. In order for these to be applied for clinical use, they require to be formulated with delivery systems. However, there are limited in vivo studies which compare different delivery platforms. Therefore, we have compared four different cationic platforms: (1) liposomes, (2) solid lipid nanoparticles (SLNs), (3) polymeric nanoparticles (NPs) and (4) emulsions, to deliver a self-amplifying mRNA (SAM) vaccine. All formulations contained either the non-ionizable cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) or dimethyldioctadecylammonium bromide (DDA) and they were characterized in terms of physico-chemical attributes<i>,</i> in vitro transfection efficiency and in vivo vaccine potency. Our results showed that SAM encapsulating DOTAP polymeric nanoparticles, DOTAP liposomes and DDA liposomes induced the highest antigen expression in vitro and, from these, DOTAP polymeric nanoparticles were the most potent in triggering humoral and cellular immunity among candidates in vivo.
The copyright agenda (2012)

More than ever, keeping tabs on copyright issues is a critical business task for library and information services. And that's just what the Australian Digital Alliance (ADA) and Australian Libraries Copyright Committee (ALCC) are doing.
SARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus Disease (2020)

We investigated 68 respiratory specimens from 35 coronavirus disease patients in Hong Kong, of whom 32 had mild disease. We found that severe acute respiratory syndrome coronavirus 2 and subgenomic RNA were rarely detectable beyond 8 days after onset of illness. However, virus RNA was detectable for many weeks by reverse transcription PCR.
Innovative Application of Ultra-Lightweight Epoxy Resin-Cement Slurry Mixture Achieved Zonal Isolation Objectives and Secured Well Integrity: Case History From Offshore Gulf of Suez (2015)

Abstract While drilling an offshore well in the Gulf of Suez (GoS), Egypt, an operator experienced severe losses of approximately 14,500 bbl of costly oil-based mud (OBM) during the drilling of a 12 1/4-in. hole section through depleted zones. It became obvious that zonal isolation objectives would not be achieved unless equivalent circulating density (ECD) was significantly reduced during cementing to help minimize and control downhole losses. Therefore, a special design of ultralightweight cement slurry combined with epoxy resin was prepared. The goal was to help reduce downhole losses during cementing while enhancing mechanical properties and achieving higher compressive strength of the set cement sheath as per well integrity requirements. This would help prevent formation stress and be helpful during future well construction operations. Epoxy resins are primarily used as secondary barriers to the primary cement sheath, curing tight casing leaks, squeezes, and during well abandonment. Generally literature on resin discusses its resilient mechanical properties, highlighting that the Poisson's ratio of epoxy resin can be closer to that of rubber, while cement is closer to that of glass. It was observed that mixing resin with cement enhances other mechanical properties of cement in addition to enhancing compressive strength. A 9-lbm/gal resin-cement slurry mixture was designed for the discussed treatment, combining 90% cement and 10% epoxy resin. The combined mixture provided all of the necessary properties of the desired cement slurry. The cement treatment was performed as designed and met all zonal isolation objectives. This cement-resin mixture can become a new solution within the industry, replacing conventional cement in many crucial primary cementing applications, particularly replacing ultralightweight high-compressive-strength slurries. This paper highlights the necessary laboratory testing, field execution procedures, and treatment evaluation methods so that this technology can be a key resource for such operations in the future.
Feature Based Time Estimation: A Review (2015)

Productivity improvement is the need of current market and manufacturing sector globally and machining time plays a very important role in reducing cost and time. In this review paper author aims to study the various factors affecting the NC machining time estimation and also tries to study the available methods used for estimating it. Hence a new prototype feature based model has been developed for NC machine time estimation. This model is then compared with the existing commercial software and other time estimation methods. The experimental data indicate that the proposed feature based model is reliable, practical and feasible. Cite this Article Akash Shukla, S.S. Jani, G.D. Acharya. Feature based time estimation–a review. Journal of Production Research and Management. 2015; 5(3): 39–44p.
Real-time high-speed three-dimensional surface imaging using band-limited illumination profilometry with a CoaXPress interface (2020)

High-speed three-dimensional (3D) surface imaging by structured-light profilometry is currently driven by numerous applications. However, the limited speeds in fringe pattern projection, image acquisition, and data transmission have strained the existing methods from reaching kilohertz-level acquisition, processing, and display of 3D information during the occurrence of dynamic events (i.e., in real time). To overcome these limitations, we have developed band-limited illumination profilometry (BLIP) with a CoaXPress interface (CI), which enables real-time high-speed 3D surface imaging. We have demonstrated the system's performance by imaging various static and fast-moving 3D objects in real time. We have also applied this system in fluid mechanics by imaging dynamics of a flag, which allowed observation of the wave propagation, gravity-induced phase mismatch, and asymmetric flapping motion. We expect CI-BLIP to find diverse scientific and industrial applications.