gebhart/patrepeval huggingface dataset:
Web Service in Context and Dependency-Aware Service Composition (2007)

Service composition enables service users to develop Web applications by composing services via Internet. Traditional service description is function-centred, but lack of composition information, which hinders service composition with respect to service contexts. In this paper, we examine service composition information (i.e. service contexts and service dependency). The context- aware service management platform that we developed provides support for service users to compose services by managing service dependency.
LUMINESCENCE PROPERTIES OF ZnS QUANTUM DOTS EMBEDDED IN POLYMER MATRIX (2011)

Zinc Sulfide (ZnS) quantum dots of sizes 2.68-4.8 nm, embedded on polyvinyl alcohol (PVA) matrix, have been synthesized at 70C by chemical route. X-ray diffraction (XRD), High Resolution Transmission Electron Microscopy (HRTEM), Scanning Electron Microscopy (SEM), UV-VIS Spectroscopy and Photoluminescence (PL) Spectroscopy has been adopted for sample characterization. Optical absorption spectra showed strong blue shift, which is an indication of strong quantum confinement. Photoluminescence spectra of the sample have been recorded at room temperature and observed two peaks centred around 415 nm and 440 nm. We have assigned the first peak due to band gap transitions while the later due to sulfur vacancy in the sample.
Evaluation of Molecular Assays for Rapid Detection of Methicillin-Resistant <i>Staphylococcus aureus</i> (2010)

The diagnostic sensitivities of the BD GeneOhm and Cepheid Xpert assays were compared using culture on log-serial dilutions of well-characterized methicillin-resistant Staphylococcus aureus (MRSA) and non-MRSA strains and on nasal and groin swabs from patients with histories of MRSA carriage. The sensitivities of GeneOhm and Xpert were high at 10(3)-CFU/ml MRSA concentrations (92.3% and 96.3%, respectively) although decreased considerably (<35%) at a 1-log-lower concentration. Unexpectedly, both assays also detected select coagulase-negative staphylococci, which requires further evaluation.
Coupling of Helmholtz resonators to improve acoustic liners for turbofan engines at low frequency (1975)

An analytical and test program was conducted to evaluate means for increasing the effectiveness of low frequency sound absorbing liners for aircraft turbine engines. Three schemes for coupling low frequency absorber elements were considered. These schemes were analytically modeled and their impedance was predicted over a frequency range of 50 to 1,000 Hz. An optimum and two off-optimum designs of the most promising, a parallel coupled scheme, were fabricated and tested in a flow duct facility. Impedance measurements were in good agreement with predicted values and validated the procedure used to transform modeled parameters to hardware designs. Measurements of attenuation for panels of coupled resonators were consistent with predictions based on measured impedance. All coupled resonator panels tested showed an increase in peak attenuation of about 50% and an increase in attenuation bandwidth of one one-third octave band over that measured for an uncoupled panel. These attenuation characteristics equate to about 35% greater reduction in source perceived noise level (PNL), relative to the uncoupled panel, or a reduction in treatment length of about 24% for constant PNL reduction. The increased effectiveness of the coupled resonator concept for attenuation of low frequency broad spectrum noise is demonstrated.
Synthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaine (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaineJoseph J. Tufariello, George B. Mullen, John J. Tegeler, Eugene J. Trybulski, Shing Chun Wong, and S. Asrof AliCite this: J. Am. Chem. Soc. 1979, 101, 9, 2435–2442Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/ja00503a033https://doi.org/10.1021/ja00503a033research-articleACS PublicationsRequest reuse permissionsArticle Views1975Altmetric-Citations133LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tristetraprolin Down-regulates Interleukin-8 and Vascular Endothelial Growth Factor in Malignant Glioma Cells (2008)

Malignant gliomas are highly aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), and tumor necrosis factor-alpha, for example, are up-regulated in these tumors to promote angiogenesis and proliferation. RNA stability, mediated through adenine and uridine-rich elements (ARE) in the 3' untranslated region, is a critical control point for regulating these growth factors. RNA half-life is predominantly governed by a balance between stabilizing and destabilizing factors that bind to ARE. We have previously shown that the stabilizing factor HuR is overexpressed in malignant gliomas and linked to RNA stabilization of angiogenic growth factors. Here, we report that the destabilizing factor tristetraprolin (TTP) is also ubiquitously expressed in primary malignant glioma tissues and cell lines. In contrast to benign astrogliotic tissues, however, the protein was hyperphosphorylated, with evidence implicating the p38/mitogen-activated protein kinase (MAPK) pathway. Conditional overexpression of TTP as a transgene in malignant glioma cells led to RNA destabilization of IL-8 and VEGF and down-regulation of protein production. Analysis of in vivo RNA binding indicated a shift of mRNA toward ectopic TTP and away from endogenous HuR. This biochemical phenotype was associated with a decrease in cell proliferation, loss of cell viability, and apoptosis. We postulate that hyperphosphorylation of TTP via p38/MAPK promotes progression of malignant gliomas by negatively regulating its RNA destabilizing function.
A Novel DNA-Binding Protein Bound to the Mitochondrial Inner Membrane Restores the Null Mutation of Mitochondrial Histone Abf2p in <i>Saccharomyces cerevisiae</i> (1998)

The yeast mitochondrial HMG-box protein, Abf2p, is essential for maintenance of the mitochondrial genome. To better understand the role of Abf2p in the maintenance of the mitochondrial chromosome, we have isolated a multicopy suppressor (YHM2) of the temperature-sensitive defect associated with an abf2 null mutation. The function of Yhm2p was characterized at the molecular level. Yhm2p has 314 amino acid residues, and the deduced amino acid sequence is similar to that of a family of mitochondrial carrier proteins. Yhm2p is localized in the mitochondrial inner membrane and is also associated with mitochondrial DNA in vivo. Yhm2p exhibits general DNA-binding activity in vitro. Thus, Yhm2p appears to be novel in that it is a membrane-bound DNA-binding protein. A sequence that is similar to the HMG DNA-binding domain is important for the DNA-binding activity of Yhm2p, and a mutation in this region abolishes the ability of YHM2 to suppress the temperature-sensitive defect of respiration of the abf2 null mutant. Disruption of YHM2 causes a significant growth defect in the presence of nonfermentable carbon sources such as glycerol and ethanol, and the cells have defects in respiration as determined by 2,3,5,-triphenyltetrazolium chloride staining. Yhm2p may function as a member of the protein machinery for the mitochondrial inner membrane attachment site of mitochondrial DNA during replication and segregation of mitochondrial genomes.
Kinetics of the oxidation of zinc sulfide (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of the oxidation of zinc sulfideGajanan M. Prabhu, Dean L. Ulrichson, and Allen H. PulsiferCite this: Ind. Eng. Chem. Fundamen. 1984, 23, 3, 271–273Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/i100015a001https://doi.org/10.1021/i100015a001research-articleACS PublicationsRequest reuse permissionsArticle Views654Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Neuromorphic Systems: Engineering Silicon from Neurobiology (1998)

Neuromorphic systems are implementations in silicon of sensory and neural systems whose architecture and design are based on neurobiology. This growing area offers exciting possibilities, such as sensory systems that can compete with human senses and pattern recognition systems that can run in real time. It is at the intersection of neurophysiology, computer science and electrical engineering. This book brings together recent developments in Europe and the US, so that researchers in both academia and industry can find out about the state of the art. As well as elementary material on what neuromorphic systems are and why they are growing in importance, the book contains details of current work. There are articles on aspects of implementing sensory neuromorphic systems, and also on neuromorphic hardware
Online-specific fear of missing out and Internet-use expectancies contribute to symptoms of Internet-communication disorder (2017)

Some of the most frequently used online applications are Facebook, WhatsApp, and Twitter. These applications allow individuals to communicate with other users, to share information or pictures, and to stay in contact with friends all over the world. However, a growing number of users suffer from negative consequences due to their excessive use of these applications, which can be referred to as Internet-communication disorder. The frequent use and easy access of these applications may also trigger the individual's fear of missing out on content when not accessing these applications. Using a sample of 270 participants, a structural equation model was analyzed to investigate the role of psychopathological symptoms and the fear of missing out on expectancies towards Internet-communication applications in the development of symptoms of an Internet-communication disorder. The results suggest that psychopathological symptoms predict higher fear of missing out on the individual's Internet-communication applications and higher expectancies to use these applications as a helpful tool to escape from negative feelings. These specific cognitions mediate the effect of psychopathological symptoms on Internet-communication disorder. Our results are in line with the theoretical model by Brand et al. (2016) as they show how Internet-related cognitive bias mediates the relationship between a person's core characteristics (e.g., psychopathological symptoms) and Internet-communication disorder. However, further studies should investigate the role of the fear of missing out as a specific predisposition, as well as specific cognition in the online context.
A New, Expressed Multigene Family Containing a Hot Spot for Insertion of Retroelements Is Associated with Polymorphic Subtelomeric Regions of <i>Trypanosoma brucei</i> (2002)

We describe a novel gene family that forms clusters in subtelomeric regions of Trypanosoma brucei chromosomes and partially accounts for the observed clustering of retrotransposons. The ingi and ribosomal inserted mobile element (RIME) non-LTR retrotransposons share 250 bp at both extremities and are the most abundant putatively mobile elements, with about 500 copies per haploid genome. From cDNA clones and subsequently in the T. brucei genomic DNA databases, we identified 52 homologous gene and pseudogene sequences, 16 of which contain a RIME and/or ingi retrotransposon inserted at exactly the same relative position. Here these genes are called the RHS family, for retrotransposon hot spot. Comparison of the protein sequences encoded by RHS genes (21 copies) and pseudogenes (24 copies) revealed a conserved central region containing an ATP/GTP-binding motif and the RIME/ingi insertion site. The RHS proteins share between 13 and 96% identity, and six subfamilies, RHS1 to RHS6, can be defined on the basis of their divergent C-terminal domains. Immunofluorescence and Western blot analyses using RHS subfamily-specific immune sera show that RHS proteins are constitutively expressed and occur mainly in the nucleus. Analysis of Genome Survey Sequence databases indicated that the Trypanosoma brucei diploid genome contains about 280 RHS (pseudo)genes. Among the 52 identified RHS (pseudo)genes, 48 copies are in three RHS clusters located in subtelomeric regions of chromosomes Ia and II and adjacent to the active bloodstream form expression site in T. brucei strain TREU927/4 GUTat10.1. RHS genes comprise the remaining sequence of the size-polymorphic "repetitive region" described for T. brucei chromosome I, and a homologous gene family is present in the Trypanosoma cruzi genome.
Inhibition of dendritic Ca<sup>2+</sup> spikes by GABA<sub>B</sub> receptors in cortical pyramidal neurons is mediated by a direct G<sub>i/o</sub>‐βγ‐subunit interaction with Ca<sub>v</sub>1 channels (2012)

Voltage-dependent calcium channels (VDCCs) serve a wide range of physiological functions and their activity is modulated by different neurotransmitter systems. GABAergic inhibition of VDCCs in neurons has an important impact in controlling transmitter release, neuronal plasticity, gene expression and neuronal excitability. We investigated the molecular signalling mechanisms by which GABA(B) receptors inhibit calcium-mediated electrogenesis (Ca(2+) spikes) in the distal apical dendrite of cortical layer 5 pyramidal neurons. Ca(2+) spikes are the basis of coincidence detection and signal amplification of distal tuft synaptic inputs characteristic for the computational function of cortical pyramidal neurons. By combining dendritic whole-cell recordings with two-photon fluorescence Ca(2+) imaging we found that all subtypes of VDCCs were present in the Ca(2+) spike initiation zone, but that they contribute differently to the initiation and sustaining of dendritic Ca(2+) spikes. Particularly, Ca(v)1 VDCCs are the most abundant VDCC present in this dendritic compartment and they generated the sustained plateau potential characteristic for the Ca(2+) spike. Activation of GABA(B) receptors specifically inhibited Ca(v)1 channels. This inhibition of L-type Ca(2+) currents was transiently relieved by strong depolarization but did not depend on protein kinase activity. Therefore, our findings suggest a novel membrane-delimited interaction of the G(i/o)-βγ-subunit with Ca(v)1 channels identifying this mechanism as the general pathway of GABA(B) receptor-mediated inhibition of VDCCs. Furthermore, the characterization of the contribution of the different VDCCs to the generation of the Ca(2+) spike provides new insights into the molecular mechanism of dendritic computation.
Iron(III) Oxides from Thermal ProcessesSynthesis, Structural and Magnetic Properties, Mössbauer Spectroscopy Characterization, and Applications (2002)

Structural and magnetic properties, methods of synthesis, and applications of seven iron(III) oxide polymorphs, including rare beta, epsilon, amorphous, and high-pressure forms, are reviewed. Thermal transformations resulting in the formation of iron oxides are classified according to different parameters, and their mechanisms are discussed. 57Fe Mössbauer spectroscopy is presented as a powerful tool for the identification, distinction, and characterization of individual polymorphs. The advantages of Mössbauer spectroscopy are demonstrated with two examples related to the study of the thermally induced solid-state reactions of Fe2(SO4)3.
Prevalence and Clinical Importance of Mesenteric Venous Thrombosis in the Swiss Inflammatory Bowel Disease Cohort (2014)

MVT is frequently found in patients with IBD. Among patients with CD, MVT is associated with bowel stenosis and CD-related intestinal surgery.
Rapid <i>B</i><sub>1</sub> mapping using orthogonal, equal‐amplitude radio‐frequency pulses (2011)

We present a new phase-based method for mapping the amplitude of the radio-frequency field (B(1) ) of a transmitter coil in three-dimension. This method exploits the noncommutation relation between rotations about orthogonal axes. Our implementation of this principle in the current work results in a simple relation between the phase of the final magnetization and the flip angle (FA). In this study, we focus on FAs less than 90°. Our method is rapid and easy to implement compared with the existing B(1) mapping schemes. The mapping sequence can be simply obtained by adding to a regular three-dimensional gradient-echo sequence a magnetization preparation radio-frequency pulse of the same FA but orthogonal in phase to the excitation radio-frequency pulse. This method is demonstrated capable of generating reliable maps of the B(1) field within 1 min using FAs no larger than 60°. We show that it is robust against T(1), small chemical shift, and mild background inhomogeneity. This method may especially be suitable for B(1) mapping in situations (e.g., long-T(1) and hyperpolarized-gas imaging) where magnitude-based methods are not readily applicable. A noise calculation of the FA map using this method is also presented.
Super-Resolution Imaging of Molecular Emission Spectra and Single Molecule Spectral Fluctuations (2016)

Localization microscopy can image nanoscale cellular details. To address biological questions, the ability to distinguish multiple molecular species simultaneously is invaluable. Here, we present a new version of fluorescence photoactivation localization microscopy (FPALM) which detects the emission spectrum of each localized molecule, and can quantify changes in emission spectrum of individual molecules over time. This information can allow for a dramatic increase in the number of different species simultaneously imaged in a sample, and can create super-resolution maps showing how single molecule emission spectra vary with position and time in a sample.
Aluminum and Aluminum Alloys (2012)

Abstract Aluminum is a silver‐white metallic element in group III of the periodic table. Aluminum exhibits a valence of 3+ in all compounds except for a few high temperature gaseous species in which the aluminum may be monovalent or divalent. Aluminum is the most abundant metallic element on the surface of the earth and moon, comprising 8.8% by weight of the earth's crust. It is rarely found free in nature.Because of its many desirable physical, chemical, and metallurgical properties, aluminum is the most widely used ferrous metal. The utility of the metal is enhanced by the formation of a stable adherent oxide surface that resists corrosion. Because of its high electrical conductivity and lightness, aluminum is used extensively on electrical transmission lines. Aluminum is obtained by electrolysis of purified Bauxite. Fluoride transmissions from aluminum smelting cells are a concern. Important binary alloys are Al–Fe, Al–Cu, Al–Mg, and Al–Li. Almost all commercial alloys are ternary or of higher complexity. Aluminum is used in transportation, packaging, building, electrical applications and consumer durables.
Phosphorylation of two regulatory tyrosine residues in the activation of Bruton’s tyrosine kinase via alternative receptors (1997)

Mutation of Bruton's tyrosine kinase (Btk) impairs B cell maturation and function and results in a clinical phenotype of X-linked agammaglobulinemia. Activation of Btk correlates with an increase in the phosphorylation of two regulatory Btk tyrosine residues. Y551 (site 1) within the Src homology type 1 (SH1) domain is transphosphorylated by the Src family tyrosine kinases. Y223 (site 2) is an autophosphorylation site within the Btk SH3 domain. Polyclonal, phosphopeptide-specific antibodies were developed to evaluate the phosphorylation of Btk sites 1 and 2. Crosslinking of the B cell antigen receptor (BCR) or the mast cell Fcepsilon receptor, or interleukin 5 receptor stimulation each induced rapid phosphorylation at Btk sites 1 and 2 in a tightly coupled manner. Btk molecules were singly and doubly tyrosine-phosphorylated. Phosphorylated Btk comprised only a small fraction (</=5%) of the total pool of Btk molecules in the BCR-activated B cells. Increased dosage of Lyn in B cells augmented BCR-induced phosphorylation at both sites. Kinetic analysis supports a sequential activation mechanism in which individual Btk molecules undergo serial transphosphorylation (site 1) then autophosphorylation (site 2), followed by successive dephosphorylation of site 1 then site 2. The phosphorylation of conserved tyrosine residues within structurally related Tec family kinases is likely to regulate their activation.