gebhart/patrepeval huggingface dataset:
Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer (2009)

Tumor contains small population of cancer stem cells (CSC) that are responsible for its maintenance and relapse. Analysis of these CSCs may lead to effective prognostic and therapeutic strategies for the treatment of cancer patients. We report here the identification of CSCs from human lung cancer cells using Aldefluor assay followed by fluorescence-activated cell sorting analysis. Isolated cancer cells with relatively high aldehyde dehydrogenase 1 (ALDH1) activity display in vitro features of CSCs, including capacities for proliferation, self-renewal, and differentiation, resistance to chemotherapy, and expressing CSC surface marker CD133. In vivo experiments show that the ALDH1-positive cells could generate tumors that recapitulate the heterogeneity of the parental cancer cells. Immunohistochemical analysis of 303 clinical specimens from three independent cohorts of lung cancer patients and controls show that expression of ALDH1 is positively correlated with the stage and grade of lung tumors and related to a poor prognosis for the patients with early-stage lung cancer. ALDH1 is therefore a lung tumor stem cell-associated marker. These findings offer an important new tool for the study of lung CSCs and provide a potential prognostic factor and therapeutic target for treatment of the patients with lung cancer.
<i>ePaper</i>: A personalized mobile newspaper (2009)

Abstract This paper describes ePaper , a research prototype system of a personalized newspaper on a mobile reading device. The ePaper aggregates content (i.e., news items) from various news providers, classifies the news items according to concepts from a news domain ontology, and delivers an electronic newspaper to each subscribed user (reader). The system personalizes the content of the newspaper according to the user's profiles and preferences by applying ontological content‐based and collaborative filtering algorithms. The user's profile is updated implicitly and dynamically, based on the tracking of their reading. Beyond personalization, the ePaper can also provide the user with a “standard edition” of a selected newspaper, as well as browsing capabilities in a repository of news items. The layout of the newspaper is adapted to the specifications of the reading device and to the user's preferences. In this overview paper, we highlight the main research challenges involved in the development of ePaper and describe how we addressed them.
Synthesis of $Bi0.5Na0.5TiO_3–BiFeO_3$ Solid Solution Via Combustion Synthesis Route (2009)

Na0.5Bi0.5TiO3 (NBT) and its modifications are known to be new lead-free piezo-ceramics materials and are promising candidates for environment friendly devices. An investigation was carried out on auto combustion synthesis of solid solutions (1−x) $Na0.5Bi0.5TiO_3 [NBT]–x BiFeO_3$ [BF] (x = 0.04, 0.06, 0.08). BNT-BF solid solution was prepared through citrate-nitrate solution combustion route. The pH of the precursor solution was maintain at 5 to 11before combustion took place. All combustion products were calcined at 900oC for 2 hours to examine the effect of pH variation. A considerable change in crystallite sizes is observed with change in pH value.
Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis. (1996)

We report for the first time a relationship between the Tpl-2/cot oncogene and Mouse Mammary Tumor Virus (MMTV) associated transformation of mammary gland cells. A sub-genomic library generated from a primary mammary gland tumor yielded a novel MMTV integration site which disrupted the Tpl-2/cot proto-oncogene between exons 7 and 8. Comparison of a cell line derived from normal mammary gland (comma-D) and a cell line established from an MMTV induced mammary tumor (GR) demonstrated similar rearrangements within Tpl-2/cot for the GR cells but not in the comma-D cells. These rearrangements in the cell line were accompanied by an increase in the level of Tpl-2/cot specific mRNA. This data suggests that Tpl-2/cot expression may be important in epithelial cell transformation or tumor progression.
<title>Probabilistic anti-aliasing methods for dynamic variable resolution images</title> (1996)

We have attained initial function of a real-time acuity- based video transformation. It matches the transmitted local resolution of video images to the eccentrically-varying acuity of the viewer's human visual system. In previous variable resolution imagery, a variable blockiness produces disturbing aliasing effects. We show how probabilistic methods can be useful to perform anti-aliasing on the variable resolution images, so that smoothing interpolation need not be done to defeat the aliasing. Especially when used in dynamic imaging, the methods consistently reduce the high frequency artifacts perceived by the human eye. The effectiveness of these techniques have been demonstrated with the NASA/Texas Instrument Programmable Remapper, which is able to apply the anti-aliasing methods on the fly on the low bandwidth, acuity-based video signal Video imagery will be shown to demonstrate the technique.
Standard Methods for the Analysis of Oils, Fats and Derivatives (1979)

This Standard describes a quick method for the determination of oil content of oleaginous seeds and fruits.
Fabrication and characterization of biodegradable composite film from banana stem (2009)

The zona pellucida, a transparent envelope surrounding the mammalian oocyte, comprises three glycoproteins, ZPA, ZPB and ZPC, and plays important roles in fertilization. We have previously reported that apparent relative molecular masses of bovine zona glycoproteins on SDS/PAGE under nonreducing conditions after removal of poly N-acetyllactosamine at the nonreducing portion of sugar chains with endo-beta-galactosidase are 72 000, 58 000 and 45 000 [Noguchi, S., Yonezawa, N., Katsumata, T., Hashizume, K.,Kuwayama, M., Hamano, S., Watanabe, S. & Nakano, M. (1994) Biochim. Biophys. Acta 1201, 7-14]. The N-terminal amino-acid sequences and crossreactivity to antibodies specific to each porcine zona component show that the bovine components correspond to porcine ZPA, ZPB and ZPC, respectively. In this study, we deduced amino-acid sequences of bovine ZPA and ZPB by cDNA cloning and sequencing. Identities in amino-acid sequences between bovine and porcine counterparts were 77% for ZPA and 75% for ZPB, whereas between bovine and murine counterparts identities were 57% for ZPA and 37% for ZPB. The positions of Cys were completely conserved in bovine ZPA and ZPB compared with counterparts of other mammalian species. Bovine ZPA was processed between Ala and Asp on fertilization, suggesting that the consensus motif for the processing is Ala-Asp-Asp/Glu. We purified bovine zona components and examined their sperm-binding activity with an in vitro competition assay and sperm-bead-binding assay. As a result, ZPB showed the strongest sperm-binding activity among the components. ZPC also showed sperm-binding activity and the activity per molecule was about one-sixth that of ZPB according to the result of the sperm-bead-binding assay. We could not determine if ZPA has significant sperm-binding activity, but the activity may be much lower than that of ZPB even if ZPA has significant activity. Thus, ZPB may play a major role in sperm binding in bovine zona.
Early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection: a national population-based matched cohort study (2022)

Abstract There are limited data regarding the safety of COVID-19 vaccines in early pregnancy. This may contribute to vaccine hesitancy in people who are pregnant, or who are planning pregnancy. We conducted a population-level matched cohort study assessing associations between COVID-19 vaccination and miscarriage (pregnancy loss prior to 20 weeks gestation) and ectopic pregnancy. We used electronic health records of all female residents in Scotland who were vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Primary analyses used unvaccinated women from the pre-pandemic period as controls (historical controls) matched (3:1) on maternal age, gestational age at vaccination, and season of conception; with adjustment for maternal deprivation level, rural/urban status and clinical vulnerability. Supplementary analyses used unvaccinated women from the pandemic period as controls (contemporary controls). Analyses of outcomes following SARS-CoV-2 infection were undertaken with infection rather than vaccination as the exposure. Following COVID-19 vaccination, the rate of miscarriage was 9.1% (n = 1,716) and ectopic pregnancy 1.2% (n = 126). Primary analyses found no association between vaccination and miscarriage (adjusted Odds Ratio [aOR] = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). Primary analyses also found no association between SARS-CoV-2 infection and miscarriage or ectopic pregnancy. Results of supplementary analyses were similar to primary analyses. Given that SARS-CoV-2 infection in later pregnancy carries substantial risks to women and babies, our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.
Performance of Cr mask for extreme-ultraviolet lithography (2001)

Recently, extreme ultraviolet lithography (EUVL) becomes to be a candidate for the next generation lithography (EUVL) becomes to be a candidate for the next generation lithographic technology form 70 nm down to 35 nm. In this technology, multilayer films coating on the thick glass substrate is used. We have proposed the Cr absorber mask for EUVL using wet process. Cr absorber has been generally used as photomask, and been also supposed to be a promising material as absorber for EUVL mask because of its both high extreme ultraviolet (EUV) contrast and excellent chemical durability. The mask absorber pattern typically including the patterns of 0.35micrometers width lines and spaces (L&S) has been completely fabricated without degradation of the multilayer. Furthermore, the fine patterns width of less than 0.15micrometers have been successfully fabricated in the entire mask area of the 4-inch-diameter wafer. The EUVL mask has been evaluated with the EUVL laboratory tools at the beamline BL3 at the NewSUBARU synchrotron radiation facility. Line and spaces pattern width of less than 0.1micrometers are clearly replicated and isolated lines pattern width of 40nm are also replicated. We confirmed that the mask absorber pattern fabrication process using a wet process is useful for EUVL mask.
Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System (2008)

Vertebrate hearts depend on highly specialized cardiomyocytes that form the cardiac conduction system (CCS) to coordinate chamber contraction and drive blood efficiently and unidirectionally throughout the organism. Defects in this specialized wiring system can lead to syncope and sudden cardiac death. Thus, a greater understanding of cardiac conduction development may help to prevent these devastating clinical outcomes. Utilizing a cardiac-specific fluorescent calcium indicator zebrafish transgenic line, Tg(cmlc2:gCaMP)(s878), that allows for in vivo optical mapping analysis in intact animals, we identified and analyzed four distinct stages of cardiac conduction development that correspond to cellular and anatomical changes of the developing heart. Additionally, we observed that epigenetic factors, such as hemodynamic flow and contraction, regulate the fast conduction network of this specialized electrical system. To identify novel regulators of the CCS, we designed and performed a new, physiology-based, forward genetic screen and identified for the first time, to our knowledge, 17 conduction-specific mutations. Positional cloning of hobgoblin(s634) revealed that tcf2, a homeobox transcription factor gene involved in mature onset diabetes of the young and familial glomerulocystic kidney disease, also regulates conduction between the atrium and the ventricle. The combination of the Tg(cmlc2:gCaMP)(s878) line/in vivo optical mapping technique and characterization of cardiac conduction mutants provides a novel multidisciplinary approach to further understand the molecular determinants of the vertebrate CCS.
Magnetotransport of p-type GaMnN assisted by highly conductive precipitates (2003)

GaMnN growth on GaAs (100) using a GaN single precursor via molecular beam epitaxy was undertaken. The grown layers revealed p-type conduction. It is confirmed that p-GaMnN reveals room temperature ferromagnetism with hysteresis loop having a coercivity of ∼100 Oe. The segregated phase showing a transition temperature of ∼200 K is assigned to Mn3GaN, and which enhances the conductivity of the surrounding GaMnN region. As a consequence, the GaMnN layer with segregation revealed an anomalous Hall effect at room temperature proving magnetotransport in GaMnN phase. The enhanced conductivity of GaMnN by the highly conductive second phase also revealed the importance of the role of the free carriers in the carrier-mediated ferromagnetism.
A Multidimensional Semantic Space for Data Model Independent Queries over RDF Data (2011)

The vision of creating a Linked Data Web brings together the challenge of allowing queries across highly heterogeneous and distributed datasets. In order to query Linked Data on the Web today, end-users need to be aware of which datasets potentially contain the data and also which data model describes these datasets. The process of allowing users to expressively query relationships in RDF while abstracting them from the underlying data model represents a fundamental problem for Web-scale Linked Data consumption. This article introduces a multidimensional semantic space model which enables data model independent natural language queries over RDF data. The center of the approach relies on the use of a distributional semantic model to address the level of semantic interpretation demanded to build the data model independent approach. The final multidimensional semantic space proved to be flexible and precise under real-world query conditions achieving mean reciprocal rank = 0.516, avg. precision = 0.482 and avg. recall = 0.491.
Molecular Responses to Stress Induced in Normal Human Caucasian Melanocytes in Culture by Exposure to Simulated Solar UV¶ (2005)

Melanocytes play a central role in the response of skin to sunlight exposure. They are directly involved in UV-induced pigmentation as a defense mechanism. However, their alteration can lead to melanoma, a process where the role of sun overexposure is highly probable. The transformation process whereby UV damage may result in melanoma initiation is poorly understood, especially in terms of UV-induced genotoxicity in pigmented cells, where melanin can act either as a sunscreen or as a photosensitizer. The aim of this study was to analyze the behavior of melanocytes from fair skin under irradiation mimicking environmental sunlight in terms of spectral power distribution. To do this, normal human Caucasian melanocytes in culture were exposed to simulated solar UV (SSUV, 300–400 nm). Even at relatively high doses (until 20 min exposure, corresponding to 12 kJ/m2 UV-B and 110 kJ/m2 UV-A), cell death was limited, as shown by cell viability and low occurrence of apoptosis (caspase-3 activation). Moreover, p53 accumulation was three times lower in melanocytes than in unpigmented cells such as fibroblasts after SSUV exposure. However, an important fraction of melanocyte population was arrested in G2–M phase, and this correlated well with a high induction level of the gene GADD45, 4 h after exposure. Among the genes involved in DNA repair, gene XPC was the most inducible because its expression increased more than two-fold 15 h after a 20 min exposure, whereas expression of P48 was only slightly increased. In addition, an early induction of Heme Oxygenase 1 (HO1) gene, a typical response to oxidative stress, was also observed for the first time in melanocytes. Interestingly, this induction remained significant when melanocytes were exposed to UV-A radiation only (320–400 nm), and stimulation of melanogenesis before irradiation further increased HO1 induction. These results were obtained with normal human cells after exposure to SSUV radiation, which mimicked natural sunlight. They provide new data related to gene expression and suggest that melanin in light skin could contribute to sunlight-induced genotoxicity and maybe to melanocyte transformation.
Microcomputer Usage in Marketing Departments of Fortune 500 Firms: What Should Marketing Students Study? (1990)

As microcomputer applications expand in marketing firms, providing relevant computer education for university marketing students is increasingly important. This article reports the levels and kinds of computer use in the nation's largest companies. These findings are used to recommend the content and direction of microcomputer education. Specific course content and software packages are considered.
<i>In Vitro</i> and <i>In Vivo</i> Antioxidant Potential of Hydromethanolic Extract of <i>Phoenix dactylifera</i> Fruits (2009)

The present study was aimed at investigating the antioxidant activities of the hydromethanolic extract of Phoenix dactylifera (HEPD) fruit (Arecaceae). The antioxidant activities of extract have been evaluated by using a range of in vitro assays and in vivo hepatoprotective model. In case of in vitro studies the IC50 values were found to be 160, 1400, 1115, 1050 μg/ml in DPPH, nitric oxide, superoxide, hydroxyl radical scavenging assays, respectively. In case of in vivo studies the levels of liver enzymatic, non-enzymatic systems [serum glutamate oxalo-acetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), alkaline phosphatase (ALP), total bilirubin, total protein, catalase (CAT), glutathione (GSH), superoxide dismutase (SOD)] and lipid peroxidation (LPO) were restored towards the normal value in HEPD treated carbon tetrachloride intoxicated rats. The free radical scavenging and antioxidant activities may be attributed to the presence of phenolic (pyrocatechol and gallic acid contents are 6.2 and 2.906 μg/mg, respectively), vitamin C (ascorbic acid content is 0.66 μg/mg) and flavonoid compounds (4.79 μg/mg) present in HEPD. The results obtained in the present study indicate that the Phoenix dactylifera fruit is a potential source of natural antioxidant. Keywords: Phoenix dactylifera; Antioxidant, Flavonoid; Total phenolic content; Vitamin C. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i1.2643 J. Sci. Res. 2 (1), 144-157 (2010)
The reflection of the fundamental torsional mode from cracks and notches in pipes (2003)

A quantitative study of the reflection of the T(0,1) mode from defects in pipes in the frequency range 10-300 kHz has been carried out, finite element predictions being validated by experiments on selected cases. Both cracklike defects with zero axial extent and notches with varying axial extents have been considered. The results show that the reflection coefficient from axisymmetric cracks increases monotonically with depth at all frequencies and increases with frequency at any given depth. In the frequency range of interest there is no mode conversion at axisymmetric defects. With nonaxisymmetric cracks, the reflection coefficient is a roughly linear function of the circumferential extent of the defect at relatively high frequencies, the reflection coefficient at low circumferential extents falling below the linear prediction at lower frequencies. With nonaxisymmetric defects, mode conversion to the F(1,2) mode is generally seen, and at lower frequencies the F(1,3) mode is also produced. The depth and circumferential extent are the parameters controlling the reflection from cracks; when notches having finite axial extent, rather than cracks, are considered, interference between the reflections from the start and the end of the notch causes a periodic variation of the reflection coefficient as a function of the axial extent of the notch. The results have been explained in terms of the wave-number-defect size product, ka. Low frequency scattering behavior is seen when ka < 0.1, high frequency scattering characteristics being seen when ka > 1.
Topographic Transformation as a Discrete Latent Variable (1999)

Invariance to topographic transformations such as translation and shearing in an image has been successfully incorporated into feedforward mechanisms, e.g., &quot;convolutional neural networks&quot;, &quot;tangent propagation&quot;. We describe a way to add transformation invariance to a generative density model by approximating the nonlinear transformation manifold by a discrete set of transformations. An EM algorithm for the original model can be extended to the new model by computing expectations over the set of transformations. We show how to add a discrete transformation variable to Gaussian mixture modeling, factor analysis and mixtures of factor analysis. We give results on ltering microscopy images, face and facial pose clustering, and handwritten digit modeling and recognition.
Resolving Referring Expressions in Images with Labeled Elements (2018)

Images may have elements containing text and a bounding box associated with them, for example, text identified via optical character recognition on a computer screen image, or a natural image with labeled objects. We present an end-to-end trainable architecture to incorporate the information from these elements and the image to segment/identify the part of the image a natural language expression is referring to. We calculate an embedding for each element and then project it onto the corresponding location (i.e., the associated bounding box) of the image feature map. We show that this architecture gives an improvement in resolving referring expressions, over only using the image, and other methods that incorporate the element information. We demonstrate experimental results on the referring expression datasets based on COCO and on a webpage image referring expression dataset that we developed.