gebhart/patrepeval huggingface dataset:
Contribution of the lower extremity joints to mechanical energy in running vertical jumps and running long jumps (1998)

The energy contribution of the lower extremity joints to vertical jumping and long jumping from a standing position has previously been investigated. However, the resultant joint moment contributions to vertical and long jumps performed with a running approach are unknown. Also, the contribution of the metatarsophalangeal joint to these activities has not been investigated. The objective of this study was to determine the mechanical energy contributions of the hip, knee, ankle and metatarsophalangeal joints to running long jumps and running vertical jumps. A sagittal plane analysis was performed on five male university basketball players while performing running vertical jumps and four male long jumpers while performing running long jumps. The resultant joint moment and power patterns at the ankle, knee and hip were similar to those reported in the literature for standing jumps. It appears that the movement pattern of the jumps is not influenced by an increase in horizontal velocity before take-off. The metatarsophalangeal joint was a large energy absorber and generated only a minimal amount of energy at take-off. The ankle joint was the largest energy generator and absorber for both jumps; however, it played a smaller relative role during long jumping as the energy contribution of the hip increased.
Facile synthesis of cross-linked patchy fluorescent conjugated polymer nanoparticles by click reactions (2011)

Here, we report a novel method to synthesize multifunctional nanoparticles that can be used in biological studies, such as in cell imaging and as a carrier for biomolecules/drugs. The nanoparticles were prepared either viaCu-catalyzed or cucurbit[6]uril (CB6)-catalyzed click reactions between azide groups containing hydrophobic blue, green and yellow emitting fluorene-based conjugated polymers and a hydrophilic diaminodialkyne containing cross-linker. Through the click reaction, not only does the cross-linking confer stability, but it also introduces functional groups, such as triazoles and amines, to the nanoparticles. Moreover, CB6 not only acted as a catalyst to facilitate the copper-free click reaction, but it also allowed us to obtain nanoparticles containing rotaxanes in which the triazole units were encapsulated by CB6 units. TEM images of the nanoparticles also showed that they display very interesting morphologies. Incorporation of hydrophilic functional groups to the hydrophobic conjugated polymers resulted in a distinct phase separation, producing Janus-like or patchy particles.
Synthesis, Structure, and Reactivity of O-Donor Ir(III) Complexes:  C−H Activation Studies with Benzene (2005)

Various new thermally air- and water-stable alkyl and aryl analogues of (acac-O,O)2Ir(R)(L), R-Ir-L (acac-O,O = kappa2-O,O-acetylacetonate, -Ir- is the trans-(acac-O,O)2Ir(III) motif, R = CH3, C2H5, Ph, PhCH2CH2, L = Py) have been synthesized using the dinuclear complex [Ir(mu-acac-O,O,C3)-(acac-O,O)(acac-C3)]2, [acac-C-Ir]2, or acac-C-Ir-H2O. The dinuclear Ir (III) complexes, [Ir(mu-acac-O,O,C3)-(acac-O,O)(R)]2 (R = alkyl), show fluxional behavior with a five-coordinate, 16 electron complex by a dissociative pathway. The pyridine adducts, R-Ir-Py, undergo degenerate Py exchange via a dissociative mechanism with activation parameters for Ph-Ir-Py (deltaH++ = 22.8 +/- 0.5 kcal/mol; deltaS++ = 8.4 +/- 1.6 eu; deltaG++298 K) = 20.3 +/- 1.0 kcal/mol) and CH3-Ir-Py (deltaH++ = 19.9 +/- 1.4 kcal/mol; deltaS++ = 4.4 +/- 5.5 eu; deltaG++298 K) = 18.6 +/- 0.5 kcal/mol). The trans complex, Ph-Ir-Py, undergoes quantitatively trans-cis isomerization to generate cis-Ph-Ir-Py on heating. All the R-Ir-Py complexes undergo quantitative, intermolecular CH activation reactions with benzene to generate Ph-Ir-Py and RH. The activation parameters (deltaS++ =11.5 +/- 3.0 eu; deltaH++ = 41.1 +/- 1.1 kcal/mol; deltaG++298 K = 37.7 +/- 1.0 kcal/mol) for CH activation were obtained using CH3-Ir-Py as starting material at a constant ratio of [Py]/[C6D6] = 0.045. Overall the CH activation reaction with R-Ir-Py has been shown to proceed via four key steps: (A) pre-equilibrium loss of pyridine that generates a trans-five-coordinate, square pyramidal intermediate; (B) unimolecular, isomerization of the trans-five-coordinate to generate a cis-five-coordinate intermediate, cis-R-Ir- square; (C) rate-determining coordination of this species to benzene to generate a discrete benzene complex, cis-R-Ir-PhH; and (D) rapid C-H cleavage. Kinetic isotope effects on the CH activation with mixtures of C6H6/C6D6 (KIE = 1) and with 1,3,5-C6H3D3 (KIE approximately 3.2 at 110 degrees C) are consistent with this reaction mechanism.
Dual insulated-gate field-effect transistors with cadmium sulfide active layer and a laminated polymer dielectric (2004)

We report the fabrication of dual insulated gate thin-film transistors with chemical-bath deposited cadmium sulfide active layers. The cadmium sulfide was deposited from solution onto thermally oxidized silicon wafers to form the first semiconductor–dielectric interface. The terpolymer poly(tetrafluoroethylene-co-vinylidenefluoride-co-propylene) was laminated onto the semiconductor to create the second semiconductor–dielectric interface. This device geometry allows direct comparison of the behavior of the accumulated charge at these two very different interfaces. The mobility values for these devices are in the 0.1–1 cm2/Vs range, while the on/off ratios vary from 102 to 105. The ability to laminate a dielectric to a semiconductor enables new processing routes for large area transistor arrays.
Public-key infrastructure interoperation (2002)

Certification authorities are now a reality. Commercial products enable an organization to be its own private certification authority. Certification service out-sourcers provide a more painless way to achieve the same end. Public certification service providers offer services that bind individuals or organizations together into communities. However, for certain purposes, the drive persists to link these infrastructures into ever-larger communities of interoperating infrastructures. In particular, the market demand for certificate-based single sign-on capabilities and the dream of the global Internet secure electronic mail community fuel this drive. This paper explores some major issues in achieving such interoperation, including the meaning of the cross-certification concept; the trust dilution problem; and the security, policy, and practices measures that are needed to achieve the trust needed to make such large-scale interoperation possible.
Privacy-Preserving Tensor Decomposition Over Encrypted Data in a Federated Cloud Environment (2018)

Tensors are popular and versatile tools which model multidimensional data. Tensor decomposition has emerged as a powerful technique dealing with multidimensional data. With the booming development of cloud computing, a large number of users are inclined to outsource big data storage and computations to the cloud. However, because of the rise of various privacy concerns, sensitive data usually need to be encrypted prior to being outsourced to a cloud. Computations over encrypted data in the cloud without compromising the privacy of data is still a challenge. This paper presents a novel privacy-preserving tensor decomposition approach over semantically secure encrypted big data. The proposed approach leverages properties of homomorphic encryption and employs a federated cloud to securely decompose an encrypted tensor for multiple users, without the clouds learning any knowledge about users' data. This is, to our knowledge, the first attempt to solve privacy-preserving tensor decomposition without requiring interaction between users and cloud service providers. In addition, in our approach, we present the first secure integer division and integer square root schemes over encrypted data (the dividend, divisor and radicand are in encrypted format). Finally, we prove the security of our approach under semi-trusted model and empirically analyze its effectiveness, which demonstrates the utility of our proposed approach in cloud deployments.
Ifosfamide and Vinorelbine as First-Line Chemotherapy for Advanced Non-Small Cell Lung Carcinoma (1996)

We evaluated the efficacy and toxicity of the novel combination of ifosfamide (IFX) and vinorelbine (VNB) as first-line chemotherapy in patients with stage IIIB and IV non-small cell lung cancer (NSCLC). Between March 1993 and November 1994, 44 patients (17 stage IIIB; 27 stage IV) received a regimen consisting of IFX, 2 g/m2 in a 1-h infusion, days 1-3; mesna, 400 mg/m2 in an i.v. bolus at hours 0 and 4 and 800 mg orally at hour 8, days 1-3; and VNB, 35 mg/ m2 in a 20-min infusion, days 1 and 15. During the first course only, a half dose of VNB (17.5 mg/m2) was administered on days 8 and 22. Courses were repeated every 28 days. Forty patients were fully evaluable for response, and 44 were assessable for toxicity. Objective regression was recorded in 13 of 40 patients (33%). No patient achieved a complete response. Thirteen patients presented a partial response (33%); 17 (42%) had no change; and progressive disease was observed in 10 (25%). The median duration of response was 10 months, and the median time to treatment failure for the whole group was 4 months. Median survival was 11 months. The dose-limiting toxic effect was myelosuppression. Leukopenia occurred in 25 patients (57%) and was grade 3 or 4 in 8 patients (18%). Twelve patients (27%) developed peripheral neurotoxicity, while five had mild IFX-induced CNS toxicity. Phlebitis was observed in 15 of 30 patients (50%) who did not have central implantable venous systems. The IFX-VNB combination exhibited an activity against NSCLC that was among the highest reported for non-cisplatin-containing regimens, with a toxicity profile that was easily managed.
Dallmayr, Fred (Hrsg.). Comparative Political Theory. An Introduction (2011)

PVS Politische Vierteljahresschrift , Seite 124 - 126
CATEDRAL DEL BURGO DE OSMA : la torre recupera su aspecto (2014)

Una profunda rehabilitacion ha
salvado de la ruina y el abandono
a la torre barroca de la catedral
del Burgo de Osma, uno de los
monumentos mas signifi cativos de
la provincia de Soria que, desde su
construccion en el siglo XVIII, jamas
habia sido reformada. Un trabajo
que ha devuelto el esplendor �y
tambien su sonido original�, a este
conjunto monumental.
Coulomb interactions in particle beams (1988)

A comprehensive theory has been developed to describe all manifestations of Coulomb interactions between charged particles in low- and medium-density nonrelativistic beams, e.g., as found in electron beam pattern generators and scanning electron microscopes. A survey is given of the analytical prescriptions for the calculation of the Boersch effect, trajectory displacement effect, and space-charge effect occurring in the drift space of a column. The theory is applied to the IBM EL3 and the Perkin–Elmer aeble 150 shaped spot lithography machines. The results are in close agreement with Monte Carlo simulations as well as the available experimental data.
Maneuver-Based Trajectory Planning for Highly Autonomous Vehicles on Real Road With Traffic and Driver Interaction (2010)

This paper presents the design and first test on a simulator of a vehicle trajectory-planning algorithm that adapts to traffic on a lane-structured infrastructure such as highways. The proposed algorithm is designed to run on a fail-safe embedded environment with low computational power, such as an engine control unit, to be implementable in commercial vehicles of the near future. The target platform has a clock frequency of less than 150 MHz, 150 kB RAM of memory, and a 3-MB program memory. The trajectory planning is performed by a two-step algorithm. The first step defines the feasible maneuvers with respect to the environment, aiming at minimizing the risk of a collision. The output of this step is a target group of maneuvers in the longitudinal direction (accelerating or decelerating), in the lateral direction (changing lanes), and in the combination of both directions. The second step is a more detailed evaluation of several possible trajectories within these maneuvers. The trajectories are optimized to additional performance indicators such as travel time, traffic rules, consumption, and comfort. The output of this module is a trajectory in the vehicle frame that represents the recommended vehicle state (position, heading, speed, and acceleration) for the following seconds.
Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing (2015)

Recent successful clinical trials with recombinant adeno-associated viral vectors (rAAVs) have led to a renewed interest in gene therapy. However, despite extensive developments to improve vector-manufacturing processes, undesirable DNA contaminants in rAAV preparations remain a major safety concern. Indeed, the presence of DNA fragments containing antibiotic resistance genes, wild-type AAV, and packaging cell genomes has been found in previous studies using quantitative polymerase chain reaction (qPCR) analyses. However, because qPCR only provides a partial view of the DNA molecules in rAAV preparations, we developed a method based on next-generation sequencing (NGS) to extensively characterize single-stranded DNA virus preparations (SSV-Seq). In order to validate SSV-Seq, we analyzed three rAAV vector preparations produced by transient transfection of mammalian cells. Our data were consistent with qPCR results and showed a quasi-random distribution of contaminants originating from the packaging cells genome. Finally, we found single-nucleotide variants (SNVs) along the vector genome but no evidence of large deletions. Altogether, SSV-Seq could provide a characterization of DNA contaminants and a map of the rAAV genome with unprecedented resolution and exhaustiveness. We expect SSV-Seq to pave the way for a new generation of quality controls, guiding process development toward rAAV preparations of higher potency and with improved safety profiles.
Design and Fabrication of Electrostatic Inkjet Head using Silicon Micromachining Technology (2008)

This paper presents design and fabrication of optimized geometry structure of electrostatic inkjet head. In order to verify effect of geometry shape, we simulate electric field intensity according to the head structure. The electric field strength increases linearly with increasing height of the micro nozzle. As the nozzle diameter decreases, the electric field along the periphery of the meniscus can be more concentrated. We design and fabricate the electrostatic inkjet heads, hole type and pole type, with optimized structure. It was fabricated using thick-thermal oxidation and silicon micromachining technique such as the deep reactive ion etching (DRIE) and chemical wet etching process. It is verified experimentally that the use of the MEMS inkjet head allows a stable and sustainable microdripping mode of droplet ejection. A stable micro dripping mode of ejection is observed under the voltages 2.5 kV and droplet diameter is 10 ㎛.
Pulmonary Genomics, Proteomics, and PLUNCs (2007)

Over the past decade Pulmonary Medicine, like many biomedical research fields, has benefited enormously from the major advances that have occurred in genomic and proteomic techniques. The relative abundance of potential samples including lung tissue and cells, bronchoalveolar lavage fluid (BALF), and sputum make pulmonary conditions attractive for many profiling studies, which are ultimately aimed at identifying novel diagnostic and prognostic disease markers. Thankfully, these studies have largely confirmed the presence of many expected proteins as well as the identification of novel genes and proteins. These studies do, however, lend themselves to the development (in researchers) of one of two conditions named and identified by Naftali Kaminski as AGLSS (Acute Gene List Staring Syndrome) and CGLSS (Chronic Gene List Staring Syndrome). Both conditions are characterized by sleep deprivation, refusal to return to the bench, and excitement about funny gene names, but the chronic condition may also involve paralysis of career (what is now called Kaminski's tetrad). Notwithstanding the above concerns, it is beyond doubt that the use of unbiased proteomic and genomic analyses have led to the identification of many novel molecules which by the very means of their identification are likely to play roles in the biology of the respiratory tract. In these studies there is often a selection of proteins that are consistently observed to be present and/or differentially expressed. In this short overview we will focus on members of a novel family of proteins, the PLUNCs, which may be considered as a paradigm for such gene/protein identification.
A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin (1985)

Debrisoquin hydroxylation capacity determined as the ratio of debrisoquin to 4-OH-debrisoquin (DMR) in urine after a single oral dose (10 mg) was studied in 52 nuclear families comprising 226 subjects. The relative importance of genetic and environmental factors for DMR was studied by path analysis. There was a significant negative correlation between DMR and coffee intake but no significant correlations between DMR and sex, age, alcohol intake, or smoking habits. Path analysis showed that genetic heritability was 0.79 while cultural heritability was only 0.06. Complex segregation analysis gave evidence for a major locus with incomplete dominance (d = 0.28) between a recessive and an additive gene. The frequency of the major gene was 0.31, allowing an estimate of the frequency of slow hydroxylators in the Swedish population of 9.4%. There was also evidence for a multifactorial component accounting for 14% of the total variation. It was not possible to distinguish between the different genotypes within the rapid hydroxylator phenotype. Our data agree with previous studies in British and German populations showing that two alleles at a major autosomal locus can explain most of the observed variation in DMR. The frequency of slow hydroxylators in Sweden is very similar to that reported in other European studies. The debrisoquin metabolic phenotype seems to be extensively controlled by a monogenic system and not significantly influenced by environmental factors or age.
Inversion recovery radial MRI with interleaved projection sets (2006)

The radial trajectory has found applications in cardiac imaging because of its resilience to undersampling and motion artifacts. Recent work has shown that interleaved and weighted radial imaging can produce images with multiple contrasts from a single data set. This feature was investigated for inversion recovery imaging of scar using a radial technique. The 2D radial imaging method was modified to acquire quadruply interleaved projection sets within each acquisition window of the cardiac cycle. These data were reconstructed using k-space weightings that used a smaller segment of the acquisition window for the central k-space data, the determinant of image contrast. This method generates four images with different T1 weightings. The novel approach was compared with noninterleaved radial imaging, interleaved radial without weightings, and Cartesian imaging in simulations, phantoms, and seven subjects with clinical myocardial infarction. The results show that during a typical acquisition window after an inversion pulse, magnetization changes rapidly. The interleaved acquisition provided better image quality than the noninterleaved radial acquisition. Interleaving with weighting provided better quality when the inversion time (TI) was shorter than optimal; otherwise, interleaving without weighting was superior. These methods enable a radial trajectory to be employed in conjunction with preparation pulses for viability imaging.
Riding the airways: Ultra-wideband ambient backscatter via commercial broadcast systems (2017)

Communication costs dominate the energy consumption, and ultimately limit the utility, of low power devices and sensor nodes. Backscatter communication based on deliberate and ambient sources has the potential to radically alter this paradigm by offering two to three orders of magnitude better communication efficiency (in terms of nJ/Bit) then conventional radio architectures. Initial work on ambient backscatter shows promising results but has focused on narrow band operation in well controlled laboratory settings. The goal of this work is to enable the ubiquitous deployment of ultra-low power nodes that communicate via ambient backscatter to wired Universal Backscatter Readers, in real-world environments. This is accomplished through ultra-wideband backscatter techniques that leverage the breath of commercial broadcast signals in the 80 MHz to 900 MHz range from FM radios, digital TVs, and cellular networks. Additionally the use of powered Universal Backscatter Readers allows a network of ultra-low power nodes to operate on ambient carriers as low as -80 dBm, which is typical for indoor home and office environments. For the first time we demonstrate the simultaneous use of 17 ambient signal sources to achieve node-to-reader communication distances of 50 meters, with data rates up to 1 kbps.
On Implementing a Language for Specifying Active Database Execution Models (1993)

A key issue when incorporating rules into database systems concerns understanding alternative semantics of rule application. The database programming language Heraclitus[Alg,C] is an extension of C that supports the relational algebra and novel constructs related to the specification of these semantics. In particular, the language supports deltas as &quot;firstclass citizens&quot; -- these are values corresponding to database updates, which may or may not be applied. Deltas are useful in representing the effect of rule firings, and for representing virtual database states, as they arise in the specification of several active database systems. Unlike previous work on differential files and hypothetical relations, Heraclitus supports operators for combining deltas, and also alternative implementations that incorporate the impact of deltas into conventional database operators (e.g., join). The framework also appears useful in connection with hypothetical database access, version control, specifying...
Adaptive Multiple Fault Detection and Alarm Processing for Loop System With Probabilistic Network (2004)

This paper presents the fault detection and alarm processing in loop system with fault detection system (FDS). FDS consists of adaptive architecture with probabilistic neural network (PNN). Training PNN uses the primary/backup information of protective devices to create the training sets. However, when network topology changes, adaptation capability becomes important in neural network applications. PNN can be retained and estimated effectively. With a looped system, computer simulations were conducted to show the effectiveness of the proposed system, and PNN's adapt network topology changes.
Involvement of inflammation in acute coronary syndromes assessed by levels of high-sensitivity C-reactive protein, matrix metalloproteinase-9 and soluble vascular-cell adhesion molecule-1. (2003)

These results suggest that plaque destabilized by MMP-9 produced in response to inflammation participates in the mechanism of acute coronary syndrome.