gebhart/patrepeval huggingface dataset:
Fabrication techniques enabling ultrathin nanostructured membranes for separations (2017)

The fabrication of nanostructured materials is an area of continuous improvement and innovative techniques that fulfill the demand of many fields of research and development. The continuously decreasing size of the smallest patternable feature has expanded the catalog of methods enabling the fabrication of nanostructured materials. Several of these nanofabrication techniques have sprouted from applications requiring nanoporous membranes such as molecular separations, cell culture, and plasmonics. This review summarizes methods that successfully produce through-pores in ultrathin films exhibiting an approximate pore size to thickness ratio of one, which has been shown to be beneficial due to high permeability and improved separation potential. The material reviewed includes large-area, parallel, and affordable approaches such as self-organizing polymers, nanosphere lithography, anodization, nanoimprint lithography as well as others such as solid phase crystallization and nanosphere lens lithography. The aim of this review is to provide a set of inexpensive fabrication techniques to produce nanostructured materials exhibiting pores ranging from 10 to 350 nm and a pore size to thickness ratio close to one. The fabrication methods described in this work have reported the successful manufacture of nanoporous membranes exhibiting the ideal characteristics to improve selectivity and permeability when applied as separation media in ultrafiltration.
[Medication review for dementia patients]. (2012)

Due to demographic changes we are faced with several challenges as an increasing prevalence of dementia patients. We report on a medication review of a patient with Alzheimer's disease as well as Lewy body dementia. The intake of risperidone was interrupted instead of a dose reduction which was recommended by the psychiatrist to improve mobility. As an adverse event the patient developed serious psychiatric symptoms which were treated in an acute care facility. We discussed several alternative treatment options (pipamperon, melperon, haloperidol, risperidone, clozapine, olanzapine, aripiprazol, and quetiapin) in a case conference. Due to a short half life period and insignificant anticholinergic effects we decided to choose quetiapin. Despite a small number of taken drugs we identified several potential drug related problems which were solved in a multipartite health care professional team.
Evaluation technology of VLSI reliability using hot carrier luminescence (1991)

An evaluation technology for VLSI reliability using hot carrier luminescence has been developed. Problems with conventional electrical methods have been solved by the analysis of weak luminescence emitted from operating devices. Two applications are described. First, for the gate oxide evaluation, it is found that the best stress condition is determined by monitoring uniform photon count distribution emitted from the gate capacitors. Second, a method is proposed to find the weakest transistor in an LSI circuit against hot-carrier-induced degradation by counting photon emissions. This method is applied to the analysis of SRAMs (static RAMs) when the transistors to be improved have been detected.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Genetic risk mechanisms of posttraumatic stress disorder in the human brain (2016)

Posttraumatic stress disorder (PTSD) follows exposure to a traumatic event in susceptible individuals. Recently, genome-wide association studies have identified a number of genetic sequence variants that are associated with the risk of developing PTSD. To follow up on identifying the molecular mechanisms of these risk variants, we performed genotype to RNA sequencing-derived quantitative expression (whole gene, exon, and exon junction levels) analysis in the dorsolateral prefrontal cortex (DLPFC) of normal postmortem human brains. We further investigated genotype-gene expression associations within the amygdala in a smaller independent RNA sequencing (Genotype-Tissue Expression [GTEx]) dataset. Our DLPFC analyses identified significant expression quantitative trait loci (eQTL) associations for a "candidate" PTSD risk SNP rs363276 and the expression of two genes: SLC18A2 and PDZD8, where the PTSD risk/minor allele T was associated with significantly lower levels of gene expression for both genes, in the DLPFC. These eQTL associations were independently confirmed in the amygdala from the GTEx database. Rs363276 "T" carriers also showed significantly increased activity in the amygdala during an emotional face-matching task in healthy volunteers. Taken together, our preliminary findings in normal human brains represent a tractable approach to identify mechanisms by which genetic variants potentially increase an individual's risk for developing PTSD. © 2016 Wiley Periodicals, Inc.
Pt–Ti–O Gate Si-MISFET Hydrogen Gas Sensors-Devices and Packagings (2012)

A novel hydrogen gas sensor based on platinum-titanium-oxygen gate silicon-metal-insulator-semiconductor field-effect transistors (FETs) was developed. The sensor has a unique gate structure composed of titanium and oxygen accumulated around platinum grains on top of a novel mixed layer of nanocrystalline TiOx and super heavily oxygen-doped amorphous titanium formed on SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Si substrates. The sensing amplitude, ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> (V), of the FET hydrogen sensor is well fitted by a linear function of the common logarithm of air-diluted hydrogen concentration C(ppm), i.e., ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> (V)=0.355log C(ppm)-0.610, between 100 ppm and 1%. The gradient of 0.355 V/decade at 115°C is about ten times higher than the expected 38.5 mV/decade from Nernst equation. The threshold Voltage (Vth) of FETs is reproducible, and shows excellent uniformity over the 5-inch wafers, 3σV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> of 178 mV. Packaged sensors working at 115 °C typically show power consumption of 122.5 mW at room temperature environments.
Total operational efficiency (TOE): the determination of two capacity and cycle time components and their relationship to productivity improvements in a semiconductor manufacturing line (2003)

Short cycle time manufacturing (SCM) concepts have been developed to help understand and manage the performance of a manufacturing line. SCM assumes that each tool/toolset (and hence the overall line) can be described by a performance curve that relates cycle time to throughput, with cycle time increasing non-linearly as throughput approaches capacity. Productivity improvements are realized by reducing the components of capacity loss, which increases the overall capacity and, thus, shifts the performance curve. To implement SCM, all major components of capacity loss must be defined, including the primary driver for cycle time: idle-no-WIP. In order to achieve this, the analysis must look beyond a strictly tool-centric focus to a system view focus so that the interaction between the tool, operator, work-in-progress, etc., can be included in the components of capacity loss. This paper develops and explains total operational efficiency (TOE), which is a key component of SCM. TOE describes the capacity and cycle time components of a tool/toolset in a self-consistent and hierarchical way that reflect a system level view and where the interaction of the tool, operator, WIP, etc., are taken into account. Once these components and their relationship have been defined, it is then possible to more clearly articulate responsible owners and assess the possibility of improvement. The reality of most semiconductor manufacturing lines is that tool availability is rarely the largest detractor from capacity. Instead, other issues such as the amount of automation, line layout, cycle time requirements, technology mix, etc., become the prime determiners of the effective capacity. In addition, TOE enables meaningful comparisons to be made between different lines and for the better tracking of improvements over time in any given line on a component by component basis.
Containerized Services Orchestration for Edge Computing in Software-defined Wide Area Networks (2019)

As SD-WAN disrupts legacy WAN technologies and becomes the preferred WAN technology adopted by corporations, and Kubernetes becomes the de-facto container orchestration tool, the opportunities for deploying edge-computing containerized applications running over SD-WAN are vast. Service orchestration in SD-WAN has not been provided with enough attention, resulting in the lack of research focused on service discovery in these scenarios. In this article, an in-house service discovery solution that works alongside Kubernetes' master node for allowing improved traffic handling and better user experience when running micro-services is developed. The service discovery solution was conceived following a design science research approach. Our research includes the implementation of a proof-ofconcept SD-WAN topology alongside a Kubernetes cluster that allows us to deploy custom services and delimit the necessary characteristics of our in-house solution. Also, the implementation's performance is tested based on the required times for updating the discovery solution according to service updates. Finally, some conclusions and modifications are pointed out based on the results, while also discussing possible enhancements.
Split‐Thickness Skin Grafts: An Experimental Study of Factors Related to Ease or Difficulty of Procuring Satisfactory Grafts of Skin from Man and Some Common Laboratory Animals (1978)

Split-thickness grafts of skin of satisfactory quality were found to be more difficult to obtain from rabbits than from animals of other genera. An explanation for this was sought in the histology of the skins of the various experimental animals. Density of hair was judged to be the factor most critical for ease or difficulty in procuring satisfactory split-thickness grafts of skin, and a cluster of histologic characteristics of skin seemed to have meaning for taxonomic classification. Silver's dermatome was found to be the test instrument for taking grafts from all subjects.
A Superconducting Hot Electron Bolometer Mixer for 530 GHz (1994)

To examine the relationship between intra-access pressures and vascular stenosis, we measured the total (pT ) and static (pS ) pressures and the severity of stenosis before and after percutaneous transluminal angioplasty (PTA). The dynamic pressure (△p) and static intra-access pressure ratios (SIAPR) were calculated. We analyzed the clinical correlation of △p and SIAPR with the severity and location of stenosis, and searched potential predictive factors for the severity of stenosis using multivariate regression. While SIAPR was significantly decreased only in outflow stenosis after PTA (p < 0.0001), △p was significantly increased in both inflow and in outflow stenosis (p < 0.05). SIAPR was negatively correlated with the severity of stenosis only in outflow stenosis (p < 0.0001), and △p was significantly correlated with both inflow and outflow stenosis (p < 0.05). △p was an independent predictor for the severity of stenosis in both inflow and outflow stenosis (p < 0.05). Thus, our study suggests that △p may be more clinically useful than SIAPR not only in detecting access stenosis regardless of its location, but also providing information about the severity of stenosis.
Frequency reuse scheme with reduced co-channel interferencefor fixed cellular systems (1998)

A new frequency reuse scheme which reduces co-channel interference in comparison with the conventional scheme is presented for use in fixed cellular or wireless local loop systems where the antennas of subscriber units are fixed and directional. The new scheme is evaluated in a three-sector cell plan employing frequency reuse numbers N = 4 and N = 7 as a function of the subscriber unit antenna directivity. It is shown that a substantial improvement is obtained with the new scheme compared to the conventional scheme if the subscriber unit antenna beam width is narrower than ~150 degrees. For the case of a 60 degree antenna beam width, for example, the improvement is > 7 dB in the signal to co-channel interference ratio averaged along the cell boundary for both N = 4 and N = 7 cases.
Identification and Classification of Acute Cardiac Rejection by Intragraft Transcriptional Profiling (2011)

The gene expression similarities and differences identified here in different AR settings have the potential to revise the clinical perspective on acute graft rejection, pending the results of larger studies.
The effect of teeth-on-stator labyrinth seals on rotor imbalance response (1991)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.
A bispecific antibody against human IgE and human Fc<i>γ</i>RII that inhibits antigen‐induced histamine release by human mast cells and basophils (2004)

The bispecific antibody described here is the prototype of similar molecules that could be used in new therapeutic approaches of allergic diseases based on the coaggregation of activating receptors, such as FcepsilonRI, with inhibitory receptors, such as FcgammaRIIB, that are constitutively expressed by mast cells and basophils.
Phytomolecules for Obesity and Body Weight Management (2018)

Obesity is one of the most prevailing health issues worldwide. It has been commonly found to be associated with metabolic disorders such as diabetes, hypertension, cardiovascular diseases and some form(s) of cancers. Excessive energy intake, physical inactivity and genetic susceptibility are main causal factors for obesity. In the modern era, various medicines have been developed for overweight and obese people, but nearly all these have serious side effects. Currently, plant-based natural products as anti-obesity therapeutics are largely unexplored. Many plant-derived molecules have been found to possess anti-obesity effects with advantages over chemical treatments. So there is a basic need to develop effective drugs for obesity management/treatment with minimal side effects. Plants may prove promising options for the same. Natural plant products are widely used in healthcare or as dietary supplements. The important phytomolecules include flavonoids, terpenoids, saponin, phenols and alkaloids. The majority of plant extracts are not single compounds but rather a mixture of different molecules, therefore their mechanism of action usually targets several organ and cellular systems. The phytomolecules would act through their inhibitory activities for pancreatic lipases, adipocyte differentiation or by increasing thermogenesis and anorexia. In this review, we discuss the anti-obesity potential of phytomolecules and also analyze their mechanisms for treating obesity.
Neosporosis: An Overview of Its Molecular Epidemiology and Pathogenesis (2019)

Neospora caninum (N. caninum), a cyst-forming protozoan parasite, is a major cause of bovine abortions and neonatal mortality worldwide. N. caninum has a broad intermediate host range, and its sexual cycle occurs exclusively in canids. Another species of Neospora, Neospora hughesi (N. hughesi), has been identified and causes myeloencephalitis in horses. Although molecular epidemiology studies are in their infancy, the 18S ribosomal RNA (rRNA) and ITS1 regions within the small subunit ribosomal RNA (ssuRNA) and an N. caninum species-specific DNA probe (pNc5) have been used extensively to differentiate Neospora from other closely related apicomplexan parasites. While these repetitive regions have higher sensitivity and specificity than housekeeping or antigen genes, they suffer from low discriminatory power and fail to capture intra-species diversity. Similarly, although multiple minisatellite or microsatellite marker studies have shown clear geographic substructures within Neospora, strains are often misclassified due to a convergence in the size of different alleles at microsatellite loci, known as homoplasy. Only one strain, N. caninum Liverpool (Nc-Liv), has been genome sequenced and compared with its closest relative, Toxoplasma gondii (T. gondii). Hence, detailed population genomics studies based on whole-genome sequences from multiple strains worldwide are needed in order to better understand the current population genetic structure of Neospora, and ultimately to determine more effective vaccine candidates against bovine neosporosis. The aim of this review is to outline our current understanding of the molecular epidemiology and genomics of Neospora in juxtaposition with the closely related apicomplexan parasites Hammondia hammondi and T. gondii.
PP.20.27 (2015)

Objective: Thoracic aorta dilatation is a common phenomenon in hypertensive patients. Aim of the study was to evaluate in early stage of hypertension aortic thoracic morphological parameters and their correlation with blood pressure (BP), aortic stiffness, carotid and cardiac organ damage. Design and method: In this prospective study we enrolled 135 consecutive patients without cardiovascular disease or diabetes, not smokers: 90 were never treated mild hypertensive (mean 24h-BP > 130 and/or 80mmHg), 45 were normotensive subjects matched for age, sex, anthropometic parameters. For each subject we evaluated office and 24 hours BP. Each patient underwent arterial tonometry (central BP and pulse wave velocity, PWV), echocardiography, carotid ultrasonography and blood tests. Results: 24h-hours BP, central BP and PWV were higher in hypertensives (132 ± 8/85 ± 6 vs 117 ± 7/73 ± 5 mmHg, p < 0.001; 124 ± 12 vs 116 ± 15mmHg, p = 0.013; 7 ± 1.9 vs 6.2 ± 1.2m/s, p = 0.004). Aortic root and ascending aorta diameters were normal in all subjects but higher in hypertensives (32.3 ± 3.7vs30.7 ± 4.4 mm, p = 0.04, 29.3 ± 3.6 vs 27.7 ± 3.1 mm, p = 0.01), transverse aortic arch and sino-tubular junction diameter were normal and similar in two groups. Root diameter (RD) and ascending aorta diameter (ARD) showed a weak correlation with office systolic BP (r = 0.247, p = 0.004, r = 0.186, p = 0.004) and 24-hours diastolic BP (r = 0.246, p = 0.004, r = 0.317, p = 0.001) while these didn’t correlate with office diastolic and 24-hours systolic BP. A significant correlation was also highlighted among RD, ARD and central systolic aortic pressure (r = 0.380, p = 0.001, r = 0.317, p = 0.001). They also showed significant correlation with left ventricular mass (r = 0.279, p = 0.001, r = 0.363, p = 0.001) and PWV (r = 0.224, p = 0.13, r = 0.181, p = 0.04) but not with carotid intima-media thickness. Aortic arch and sino-tubular junction diameter didn’t show any correlation with overmentioned cardiac or vascular parameters. Conclusions: In our study aortic parameters root and ascending aorta diameters resulted higher in mild hypertensives; these parameters correlated with cardiac but not carotid organ damage. Aortic remodeling was related with central blood pressure as much as office and 24 hours blood pressure. Our findings suggest a potential usefulness of central blood pressure in early hypertensives stages to predict aortic remodeling.
Bioactive Equivalence of Combinatorial Components Identified in Screening of an Herbal Medicine (2014)

This work answers the key question of which are real bioactive components for CP that have been used in clinic for many years, and provides a promising approach for discovering BECCs from herbal medicines. More importantly, the BECCs could be extended to improve quality control of herbal products and inspire an herbal medicines based discovery of combinatorial therapeutics.
Scalable low bit rate coding using an HC-RIOT coder (2003)

This paper discusses a low bit rate (LBR) wavelet based image coder that is designed to transmit over varying bandwidth network connections and is receivable by several different performance levels of decoders. It combines the discrete wavelet transform with a two stage ZTE/SPIHT zerotree entropy type coder to create a bitstream that is transmitted in base and enhancement layers with properties of progressive transmission, scalability, and perceptual optimization after a minimum bit rate is reached. A wavelet block chain (WBC) method is used in the initial ZTE coding of the low-low (LL) subband to separate and label homogenous regions of the image to the decoder without additional overhead information in the bitstream. This spatial information is then exploited to increase coding efficiency and perceptually improve the transmission of the image. This transmission is formatted such that an unequal channel protection can be applied. Lastly the new image coder has possibilities to assist in spatio-temporal segmentation method; and video object based coding.
Measurement of Copper-Binding Sites on Low Density Lipoprotein (2001)

Copper is often used to oxidize low density lipoprotein (LDL) in experiments in vitro and is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper ions to LDL is usually thought to be a prerequisite for LDL oxidation by copper, although estimates of LDL copper binding vary widely. We have developed and validated an equilibrium dialysis assay in a MOPS-buffered system to measure copper binding to LDL and have found 38.6+/-0.7 (mean+/-SEM, n=25) copper binding sites on LDL. The binding was saturated at a copper concentration of 10 micromol/L at LDL concentrations of up to 1 mg protein/mL. Copper-binding capacity increased progressively and markedly when LDL was oxidized to increasing extents. Chemical modification of histidyl and lysyl residues on apolipoprotein B-100 reduced the number of binding sites by 56% and 23%, respectively. As an example of the potential of this method to assess the effects of antioxidants on copper binding to LDL, we have shown that the flavonoids myricetin, quercetin, and catechin (but not epicatechin, kaempferol, or morin), at concentrations equimolar to the copper present (10 micromol/L), significantly decreased copper binding to LDL by 82%, 56%, and 20%, respectively.
Overview of IEEE C37.92-2005 Standard for Analog Inputs to Protective Relays From Electronic Voltage and Current Transducers (2006)

The paper gives an overview of the new IEEE standard C37.92, which defines a low-voltage (11.3 V max) analog signal interface between new types of electronic sensors, and microprocessor-based protective relays or intelligent electronic devices. The application requirements are described; the technical specifications of the interface are summarized. The paper explains electromagnetic-environment considerations. The new interface standard offers simplicity and low cost, ease of adaptation of existing relay designs, and the opportunity to transform and combine signals from existing conventional instrument transformers in hybrid protection schemes