gebhart/patrepeval huggingface dataset:
Evaluation of IP Fast Reroute Proposals (2007)

With the increasing demand for low-latency applications in the Internet, the slow convergence of the existing routing protocols is a growing concern. A number of IP fast reroute mechanisms have been developed by the IETF to address the issue. The goal of the IPFRR mechanisms is to activate alternate routing paths which avoid micro loops under node or link failures. In this paper we present a comprehensive analysis of these proposals by evaluating their coverage for a variety of inferred and synthetic ISP topologies.
Prediction of Flame Burning Velocity at Early Flame Development Time With High Exhaust Gas Recirculation (EGR) and Spark Advance (2016)

Diluting Spark-Ignited (SI) stoichiometric combustion engines with excess residual gas improves thermal efficiency, and allows spark to be advanced towards Maximum Brake Torque (MBT) timing. However, flame propagation rates decrease and misfires can occur at high Exhaust Gas Recirculation (EGR) conditions and advanced spark, limiting the maximum level of charge dilution and its benefits. The misfire limits are often determined for a specific engine from extensive experiments covering a large range of speed, torque and actuator settings. To extend the benefits of dilute combustion while at the misfire limit, it is essential to define a parameterizable, physics-based model capable of predicting the misfire limits, with cycle to cycle varied flame burning velocity as operating conditions change based on driver demand. A cycle averaged model is the first step in this process. The current work describes a model of cycle averaged laminar flame burning velocity within the early flame development period of 0 to 3 percent mass fraction burned. A flame curvature correction method is used to account for both the effect of flame stretch and ignition characteristics, in a variable volume engine system. Comparison of the predicted and the measured flame velocity was performed using a spark plug with fiber optical access. The comparison at a small set of spark and EGR settings at fixed load and speed, shows an agreement within 30% of uncertainty, while 20% uncertainty equals ± one standard deviation over 2,000 cycles.
Nuclear roundness factor: A quantitative approach to grading in prostatic carcinoma, reliability of needle biopsy tissue, and the effect of tumor stage on usefulness (1987)

Morphometric analysis and histologic grading were performed on case material from 26 patients. Relative nuclear roundness factor (RNRF) was calculated and correlated with clinical course in 14 patients undergoing prostatectomy for stage A or B prostatic carcinoma. The only patients with progression of disease were two with RNRF of 1.10. RNRF in cases without progression ranged from 0.98 to 1.07. Histologic grading by the methods of Gleason or the M.D. Anderson system failed to discriminate between the progressing and nonprogressing groups. However, when RNRF was measured in tumors initially diagnosed as stage C or D, four of eight were below 1.10, within the range of the nonprogressing low-stage cases. Thus, the usefulness of morphometry and RNRF may be limited to low-stage disease. It was additionally found that RNRF could not be reliably measured in needle biopsy specimens.
Robust RGB-D Odometry Using Point and Line Features (2015)

Lighting variation and uneven feature distribution are main challenges for indoor RGB-D visual odometry where color information is often combined with depth information. To meet the challenges, we fuse point and line features to form a robust odometry algorithm. Line features are abundant indoors and less sensitive to lighting change than points. We extract 3D points and lines from RGB-D data, analyze their measurement uncertainties, and compute camera motion using maximum likelihood estimation. We prove that fusing points and lines produces smaller motion estimate uncertainty than using either feature type alone. In experiments we compare our method with state-of-the-art methods including a keypoint-based approach and a dense visual odometry algorithm. Our method outperforms the counterparts under both constant and varying lighting conditions. Specifically, our method achieves an average translational error that is 34.9% smaller than the counterparts, when tested using public datasets.
Measuring waveform quality, code-domain power, time offsets and phase offsets of CDMA signals (2002)

In 1994, the Telecommunications Industry Association (TIA) released the IS-95 and IS-97 standards developed by the TIA TR-45.5 subcommittee. These standards ensure the mobile-station/base-station compatibility of a dual-mode, wideband, spread-spectrum system-the North American CDMA (code division multiple access) cellular telephone system. The CDMA system uses orthogonal codes to provide multiple communications channels in a designated segment of the electromagnetic spectrum. The TIA IS-95/97 standards specify various measurements that must be made on CDMA base station and mobile station transmitters and receivers to ensure their compatibility, This paper describes CDMA signals and the measurements of waveform quality, code-domain power, and time and phase offsets. A signal flow diagram of the measurement algorithms is presented and performance predictions based on mathematical modeling and simulations are given, Some typical results of measurements made with the HP 83203B which is the cellular adapter for the HP 8921A/600 cell site test set are given.
Web Browser as an Application Platform (2008)

For better or worse, the web browser has become a widely used target platform for software applications. Desktop-style applications such as word processors, spreadsheets, calendars, games and instant messaging systems that were earlier written for specific operating systems, CPU architectures or devices are now written for the World Wide Web, to be used from a web browser. In this paper we summarize our experiences in using the web browser as a target platform for real applications. As a concrete example, we use the Sun¿ Labs Lively Kernel, a system that implements an exceptionally interactive web programming environment running in a web browser without any plug-in components. Based on this work, we analyze the limitations, challenges and opportunities related to the web browser as an application platform.
Properties of the new UCSB free-electron lasers (1991)

Two new far-infrared free-electron lasers (FELs) are operating in a newly constructed beam switchyard and are providing radiation to an adjoining users' facility. These have been constructed to the highest standards, resulting in substantially improved operating characteristics. For example, greatly improved electron beam recirculation now permits FEL operation to more closely match theoretical prediction and has extended operating pulse width and repetition rate. The design characteristics and operating properties of these lasers are discussed.
Introduction (2004)

Abstract Argues that the evidence and research presented in this book bear on questions that are at the centre of politics, not just in Britain, but in other industrialized countries. How society’s resources are ultimately distributed and how collective decisions through the State affect that distribution are very big issues. Explains the structure of the book and its focus on how the State affects distribution through its spending programmes and through taxation, and what the public thinks of all three.
A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing <i>In Vivo</i> (2015)

Preclinical development of RNA interference (RNAi)-based therapeutics requires a rapid, accurate, and robust method of simultaneously quantifying mRNA knockdown in hundreds of samples. The most well-established method to achieve this is quantitative real-time polymerase chain reaction (qRT-PCR), a labor-intensive methodology that requires sample purification, which increases the potential to introduce additional bias. Here, we describe that the QuantiGene(®) branched DNA (bDNA) assay linked to a 96-well Qiagen TissueLyser II is a quick and reproducible alternative to qRT-PCR for quantitative analysis of mRNA expression in vivo directly from tissue biopsies. The bDNA assay is a high-throughput, plate-based, luminescence technique, capable of directly measuring mRNA levels from tissue lysates derived from various biological samples. We have performed a systematic evaluation of this technique for in vivo detection of RNAi-based silencing. We show that similar quality data is obtained from purified RNA and tissue lysates. In general, we observe low intra- and inter-animal variability (around 10% for control samples), and high intermediate precision. This allows minimization of sample size for evaluation of oligonucleotide efficacy in vivo.
Prototype Sodium‐Ion Batteries Using an Air‐Stable and Co/Ni‐Free O3‐Layered Metal Oxide Cathode (2015)

A prototype rechargeable sodium-ion battery using an O3-Na0.90[Cu0.22 Fe0.30 Mn0.48]O2 cathode and a hard carbon anode is demonstrated to show an energy density of 210 W h kg(-1) , a round-trip energy efficiency of 90%, a high rate capability (up to 6C rate), and excellent cycling stability.
ADkwik: Web 2.0 Collaboration System for Architectural Decision Engineering. (2007)

There are no established treatment protocol for isolated lateral lymph node recurrence in patients with T1 lower rectal cancer, because such case is very rare. In our institution, this is the only recorded case of lateral node recurrence post-resection. It has been documented in several studies that salvage surgery for colorectal cancer improves prognosis. However, there were only 3 reported cases found for lateral lymph node metastasis from colorectal cancer that underwent excision. In this study, we report a rare case of lateral lymph node recurrence after trans-anal resection for T1 lower rectal cancer wherein we performed laparoscopic right lateral pelvic lymph node dissection. The procedure was done safely without any complications. No recurrence noted on follow-up. Hence, we can perform resection of isolated lateral lymph node recurrence in selected patients to achieve good prognosis.
Membrane protein folding: beyond the two stage model (2003)

The folding of alpha-helical membrane proteins has previously been described using the two stage model, in which the membrane insertion of independently stable alpha-helices is followed by their mutual interactions within the membrane to give higher order folding and oligomerization. Given recent advances in our understanding of membrane protein structure it has become apparent that in some cases the model may not fully represent the folding process. Here we present a three stage model which gives considerations to ligand binding, folding of extramembranous loops, insertion of peripheral domains and the formation of quaternary structure.
QoS-Aware Web Service Recommendation by Collaborative Filtering (2010)

With increasing presence and adoption of Web services on the World Wide Web, Quality-of-Service (QoS) is becoming important for describing nonfunctional characteristics of Web services. In this paper, we present a collaborative filtering approach for predicting QoS values of Web services and making Web service recommendation by taking advantages of past usage experiences of service users. We first propose a user-collaborative mechanism for past Web service QoS information collection from different service users. Then, based on the collected QoS data, a collaborative filtering approach is designed to predict Web service QoS values. Finally, a prototype called WSRec is implemented by Java language and deployed to the Internet for conducting real-world experiments. To study the QoS value prediction accuracy of our approach, 1.5 millions Web service invocation results are collected from 150 service users in 24 countries on 100 real-world Web services in 22 countries. The experimental results show that our algorithm achieves better prediction accuracy than other approaches. Our Web service QoS data set is publicly released for future research.
Influence of bilayer resist processing on p-i-n OLEDs: towards multicolor photolithographic structuring of organic displays (2015)

Recently, bilayer resist processing combined with development in hydrofluoroether (HFE) solvents has been shown to enable single color structuring of vacuum-deposited state-of-the-art organic light-emitting diodes (OLED). In this work, we focus on further steps required to achieve multicolor structuring of <i>p-i-n</i> OLEDs using a bilayer resist approach. We show that the green phosphorescent OLED stack is undamaged after lift-off in HFEs, which is a necessary step in order to achieve RGB pixel array structured by means of photolithography. Furthermore, we investigate the influence of both, double resist processing on red OLEDs and exposure of the devices to ambient conditions, on the basis of the electrical, optical and lifetime parameters of the devices. Additionally, water vapor transmission rates of single and bilayer system are evaluated with thin Ca film conductance test. We conclude that diffusion of propylene glycol methyl ether acetate (PGMEA) through the fluoropolymer film is the main mechanism behind OLED degradation observed after bilayer processing.
An assessment of the new LS-DYNA layered solid element: basics, patch simulation and its potential for thick composite structure analysis (2009)

Summary: One major component of fuel cell vehicles is the hydrogen storage system. A promising and nowadays mostly used approach is to store hydrogen in wet wound carbon fiber reinforced plastic (CFRP) vessels manufactured by filament winding process with an operating pressure of up to 70 MPa (hereafter referred as H2 vessel). Due to the inherent complexity and 3-dimensional nature, accurate behavior of such thick composite structures in impact simulations needs an adequate representation of the composite plies. Modeling thick composite structures with 2-dimensional elements will produce inaccurate results in transverse normal direction. Thus 3D modeling should be used but to model each ply with one solid element leads to undesirably big models and is impractical for large structures. Thus representation of several plies in one solid element and more such elements across thickness is desired. Also, solid elements are needed to represent the 3-dimensional state of stress and impact direction normal to the outer vessel surface. A new layered solid element formulation is implemented in LS-DYNA® Version 971 R4 allowing the definition of multiple integration points through the thickness in combination with arbitrary material orientation. The above new element formulation is presented in this paper describing different patch simulation results and simulation results for thick composite structures such as hydrogen storage H2 vessels.
Quantitative assessment of higher‐order chromatin structure of the <i>INK4/ARF</i> locus in human senescent cells (2012)

Somatic cells can be reset to oncogene-induced senescent (OIS) cells or induced pluripotent stem (iPS) cells by expressing specified factors. The INK4/ARF locus encodes p15(INK4b) , ARF, and p16(INK4a) genes in human chromosome 9p21, the products of which are known as common key reprogramming regulators. Compared with growing fibroblasts, the CCCTC-binding factor CTCF is remarkably up-regulated in iPS cells with silencing of the three genes in the locus and is reversely down-regulated in OIS cells with high expression of p15(INK4b) and p16(INK4a) genes. There are at least three CTCF-enriched sites in the INK4/ARF locus, which possess chromatin loop-forming activities. These CTCF-enriched sites and the p16(INK4a) promoter associate to form compact chromatin loops in growing fibroblasts, while CTCF depletion disrupts the loop structure. Interestingly, the loose chromatin structure is found in OIS cells. In addition, the INK4/ARF locus has an intermediate type of chromatin compaction in iPS cells. These results suggest that senescent cells have distinct higher-order chromatin signature in the INK4/ARF locus.
Recurrent Support Vector Machines For Slot Tagging In Spoken Language Understanding (2016)

Yangyang Shi, Kaisheng Yao, Hu Chen, Dong Yu, Yi-Cheng Pan, Mei-Yuh Hwang. Proceedings of the 2016 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2016.
COMPARISON OF THE METABOLIC CONTROL OF DIABETES ACHIEVED BY WHOLE PANCREAS TRANSPLANTATION AND PANCREATIC ISLET TRANSPLANTATION IN RATS (1988)

To compare the long-term effectiveness of whole pancreas transplantation and pancreatic islet transplantation in controlling the metabolic disorders of alloxan diabetes, metabolic studies were performed monthly for 2 years in 4 groups of highly inbred rats: (1) NC-116 nondiabetic controls; (2) DC-273 untreated alloxan-diabetic controls; (3) PDT-182 rats that received syngeneic pancreaticoduodenal transplants shortly after induction of diabetes with alloxan; and (4) IT-92 rats that received an intraportal injection of at least 1500, but usually 2000, syngeneic pancreatic islets shortly after induction of diabetes with alloxan. Whole pancreas transplantation maintained strict metabolic control throughout the 2 years of study. In group PDT, hyperglycemia was abolished; plasma glucose concentration was maintained tightly within the normal range; markedly depressed plasma insulin levels were raised to above normal; glucose tolerance tests had insulin levels above normal and glucose levels that increased less and declined more rapidly than normal; and body weight gain and growth approached normal. In contrast, pancreatic islet transplantation failed to maintain precise metabolic control. In group IT, plasma glucose concentration initially fell to normal but then was elevated significantly above normal beginning with the 3rd posttransplant month; plasma insulin level declined progressively after the 6th posttransplant month; glucose tolerance tests had a diabetic glucose tolerance curve as a result of a markedly deficient plasma insulin response; and body weight gain and growth were significantly less than in group PDT. The results of these long-term metabolic studies may explain the effectiveness of whole pancreas transplantation and the ineffectiveness of pancreatic islet transplantation in preventing diabetic nephropathy.
Application of gravity currents to the migration of CO2 in heterogeneous saline formations (2009)

Gravity currents form when carbon dioxide is injected into a saline formation beneath a sealing caprock, since under most conditions the injected CO2 is significantly less dense than the formation water. The phenomena of gravity currents are examined for the simplest kind of heterogeneity, that of two horizontal layers of contrasting permeability. The results of numerical simulations of single phase flow are compared with both laboratory experiments and analytical predictions. The results on gravity currents are applied to the spreading of the gas phase CO2 and also to the slumping of the dissolved CO2.
우리나라 사망력 모형의 변천과 가정 고찰 - Lee-Carter 류를 중심으로 - (2018)

빠른 고령화로 고령층의 증가는 인구구조 변화와 인구고령화에 영향을 미친다. 예전부터 선진국은 인구고령화를 주요현안으로 간주하여 고령화로 인한 연금 재정건전성, 건강 및 노인 복지 시스템의 지속 가능성에 집중하고 있다. 이처럼 고령층의 증가로 인구구조 변화와 인구고령화에 미치는 사망률 예측은 어느 때보다도 중요하다. 본 논문은 통계청 1970-2016년 각세별 생명표 자료를 활용하여 사망률 모형 6가지를 비교하였다. 이들 모형은 Lee-Carter(LC) 모형 (Lee and Carter, Journal of the American Statistical Association, 87, 659-671, 1992)에 근원을 두고 있으며, LC 의 가정을 수정하고 개선한 것이다. 이들 개선과정과 가정검토를 모형별로 살펴보고 우리나라에 적합한 사망률 모형을 모색했다. 분석결과 빠른 고령화와 연령별 사망률의 개선 효과를 보이는 우리나라의 경우 기대수명에 큰 변화를 주지 않고 이들 현상을 반영하고 연령별 사망률 패턴을 수정하는 LC-ER 모형 (Li 등, Demography, 50, 2037-2051, 2013)과 Li-Lee 모형과 LC-ER모형을 조합한 LL&LC-ER 모형으로 사망률을 예측하는 것이 바람직하다.
Quantitative Metabolomic Profiling of Serum and Urine in DSS-Induced Ulcerative Colitis of Mice by <sup>1</sup>H NMR Spectroscopy (2010)

Quantitative profiling of a large number of metabolic compounds is a promising method to detect biomarkers in inflammatory bowel diseases (IBD), such as ulcerative colitis (UC). We induced an experimental form of UC in mice by treatment with dextran sulfate sodium (DSS) and characterized 53 serum and 69 urine metabolites by use of (1)H NMR spectroscopy and quantitative ("targeted") analysis to distinguish between diseased and healthy animals. Hierarchical multivariate orthogonal partial least-squares (OPLS) models were developed to detect and predict separation of control and DSS-treated mice. DSS treatment resulted in weight loss, colonic inflammation, and increase in myeloperoxidase activity. Metabolomic patterns generated from the OPLS data clearly separated DSS-treated from control mice with a slightly higher predictive power (Q(2)) for serum (0.73) than urine (0.71). During DSS colitis, creatine, carnitine, and methylamines increased in urine while in serum, maximal increases were observed for ketone bodies, hypoxanthine, and tryptophan. Antioxidant metabolites decreased in urine whereas in serum, glucose and Krebs cycle intermediates decreased strongly. Quantitative metabolic profiling of serum and urine thus discriminates between healthy and DSS-treated mice. Analysis of serum or urine seems to be equally powerful for detecting experimental colitis, and a combined analysis offers only a minor improvement.
Toward spoken dialogue as mutual agreement (2010)

This paper re-envisions human-machine dialogue as a set of mutual agreements between a person and a computer. The intention is to provide the person with a habitable experience that accomplishes her goals, and to provide the computer with sufficient flexibility and intuition to support them. The application domain is particularly challenging: for its vocabulary size, for the number and variety of its speakers, and for the complexity and number of the possible instantiations of the objects under discussion. The brittle performance of a traditional spoken dialogue system in such a domain motivates the design of a new, more robust social system, one where dialogue is necessarily represented on a variety of different levels.
Mobile Robot Sensor Fusion with Fuzzy ARTMAP (1998)

The raw sensory input available to a mobile robot suffers from a variety of shortcomings. Sensor fusion can yield a percept more veridical than is available from any single sensor input. In this project, the fuzzy ARTMAP neural network is used to fuse sonar and visual sonar on a B14 mobile robot. The neural network learns to associate specific sensory inputs with a corresponding distance metric. Once trained, the network yields predictions of range to obstacles that are more accurate than those provided by either sensor type alone. This improvement in accuracy holds across all distances and angles of approach tested.
Testing of monoclonal antibodies against the T-cell receptor associated with ankylosing spondylitis (2018)

In the last decade there has been a tendency to move away from the symptomatic treatment and embrace targeted therapies. This process is underpinned by the accumulated knowledge of the mechanisms underlying the pathogenesis of diseases and driven by the advances in biotechnologies. T-cell receptors with variable TRBV9 β-chain regions have been recently associated with spondyloarthritis including its subtype, ankylosing spondylitis. The aim of this work was to engineer a chimeric monoclonal antibody targeting the variable region of the T-cell receptor β-chain encoded by the TRBV9 gene segment and assess its specificity and cytotoxicity. Using flow cytometry and next generation sequencing, we demonstrate that the engineered chimeric antibody is highly specific and exhibits cytotoxic activity against its target. Approaches based on the use of therapeutic chimeric antibodies against pathogenic T-clones may hold great promise for the therapy of autoimmune disorders in general and AS in particular.