gebhart/patrepeval huggingface dataset:
Glioblastoma-secreted soluble CD44 activates tau pathology in the brain (2018)

During aggressive tumor growth and migration, glioblastoma cells secrete diverse molecules and adhesion proteins to the extracellular matrix. Yet, the biochemical effects of the glioblastoma secretome in the brain remain largely unknown. Here we show that soluble CD44 secreted from glioblastoma cells induces neuronal degeneration through the activation of tau pathology in the brain. Glioblastoma-xenograft tissues showed a number of degenerating neurons bearing highly phosphorylated tau. Through a series of secretome-analyses, we identified that soluble CD44 was the responsible protein inducing tau phosphorylation and aggregation (EC<sub>50</sub> = 19.1 ng/mL). The treatment of sCD44 to primary hippocampal neurons-induced tau hyperphosphorylation, leading to neuronal degeneration. Also, the injection of sCD44 into the brains of tau transgenic mice induced tau hyper-phosphorylation in hippocampal neurons. Altogether, our data suggest a neurodegenerative role of sCD44 in promoting tau pathology and serving as a molecular link between glioblastoma and neurodegeneration.
Mechanism of Immobilized Protein A Binding to Immunoglobulin G on Nanosensor Array Surfaces (2015)

Protein A is often used for the purification and detection of antibodies such as immunoglobulin G (IgG) because of its quadrivalent domains that bind to the Fc region of these macromolecules. However, the kinetics and thermodynamics of the binding to many sensor surfaces have eluded mechanistic description due to complexities associated with multivalent interactions. In this work, we use a near-infrared (nIR) fluorescent single-walled carbon nanotube sensor array to obtain the kinetics of IgG binding to protein A, immobilized using a chelated Cu(2+)/His-tag chemistry to hydrogel dispersed sensors. A bivalent binding mechanism is able to describe the concentration dependence of the effective dissociation constant, KD,eff, which varies from 100 pM to 1 μM for IgG concentrations from 1 ng mL(-1) to 100 μg mL(-1), respectively. The mechanism is shown to describe the unusual concentration-dependent scaling demonstrated by other sensor platforms in the literature as well, and a comparison is made between resulting parameters. For comparison, we contrast IgG binding with that of human growth hormone (hGH) to its receptor (hGH-R) which displays an invariant dissociation constant at KD = 9 μM. These results should aid in the use of protein A and other recognition elements in a variety of sensor types.
MicroRNA-183-5p promotes the proliferation, invasion and metastasis of human pancreatic adenocarcinoma cells (2015)

The aim of the current study was to investigate the potential role of microRNA-183-5p (miR-183-5p) in the proliferation, invasion and metastasis of pancreatic cancer, and to identify promising target genes of oncogenic miR-183-5p. Western blotting and quantitative polymerase chain reaction (qPCR) were used to investigate whether these oncogenic microRNAs may be useful as biomarkers in pancreatic carcinoma (PaCa). Potential target genes were verified using miRDB, PicTar and TargetSCAN, and qPCR was used to detect the expression of miR-183 and suppressor of cytokine signaling 6 (SOCS-6; a potential target of miR-183) in PANC-1 PaCa cells and in the HPDE6-C7 pancreatic ductal cell line for comparison. The function of miR-183 in cell proliferation, wound healing, invasion and migration was also investigated using a miR-183 inhibitor. Western blot analysis was used to confirm SOCS-6 as a tumor suppressor and qPCR was used to detect and confirm that this potential target gene is directly regulated by miR-183. The results indicated that the expression of miR-183 in PANC-1 cells was upregulated compared with that in HPDE6-C7 cells, whilst the expression of SOCS-6 was downregulated. SOCS-6 expression was also significantly lower in PaCa tissues compared with that in matched normal pancreatic tissues from PaCa patients. Furthermore, expression of miR-183 was inversely correlated with that of SOCS-6. miR-183 knockdown decreased cell growth and motility in pancreatic cancer cells and significantly increased the expression of SOCS-6. These data suggest that oncogenic miR-183 may be useful as a pancreatic cancer biomarker. In addition, inhibition of miR-183 expression may be beneficial as PaCa treatment. SOCS-6 is a potential target gene of miR-183.
Drugs interfering with mitochondrial disorders (2009)

Avoiding or discontinuing mitochondrion-toxic drugs in MID patients can have a significant impact on the course and outcome of these patients.
Volterra kernel interpolation for system modeling and predistortion purposes (2006)

RF power amplifiers of wireless communication systems are usually driven deep into their nonlinear region to obtain a higher efficiency. The price paid for the increased efficiency is the distortion of the transmission signal caused by the inherent nonlinearity of the amplifier. To fulfill a given spectral mask for the transmission signal and to avoid an unacceptable high bit-error rate the amplifier must be linearized. One of the most powerful and efficient methods is digital baseband predistortion. The predistorter must be operated on a sampling frequency which is sufficiently high to be able to compensate the out-off-band spectral components caused by the amplifier. Also for system-level simulations of communication systems, amplifier behavior models (high sampling rate) are used to estimate the generated distortion. It is well known that nonlinear system identification can be accomplished on the Nyquist-rate regarding the input signal bandwidth, but however for several applications, systems operating on the output signal Nyquist-rate are required. In this paper we show how such systems can be obtained by a multi-dimensional kernel interpolation without the drawbacks of a high condition number for the kernel estimation and the demand for an expensive high sampling rate ADC.
Theory for the semi-analytical calculation of oil recovery and effective relative permeabilities using streamtubes (1997)

A semi-analytical method has been developed for calculating oil recovery in two and three dimensions, and for calculating effective relative permeabilities for coarse grids. The calculations are based on the assumption that the effects of a changing mobility field can be accounted for by using fixed streamtube geometries with flowrates updated to account for the changing mobility distribution. The single-phase pressure distribution from a numerical solution of Laplace's equation is used to calculate the pressure distribution for a two-phase flow based on a mapping of the solution of the Buckley-Leverett equation onto the streamtubes derived from the single-phase solution. The displacement calculations for oil recovery are based on theory previously developed by Dykstra and Parsons, extended to include the effects of spatially varying permeability and continuously changing mobilities, as occurs in solutions of the Buckley-Leverett equation for typical values of the mobility ratio. This idea has also been extended to the calculation of effective relative permeabilities for coarse-grid simulation and finally establishes the proper rules for averaging the results of fine-grid numerical simulations of two-phase flow for the definition of effective two-phase flow properties on coarse grids. These calculations have been generalized to three-dimensional flows by the simple device of conceptually inserting a gridded plane across the flow and defining each streamtube at that location as those streamlines which pass through any one of the grid cells. When combined with time-of-flight calculations from the gridded plane to both the producer and injector, the distribution of pore volume along each streamtube can be calculated. This information, combined with a tabulation of the single-phase, steady-state pressure distribution along each streamtube, provides all of the information needed for the semi-analytical calculation of oil recovery and effective flow properties in three-dimensional flows. © 1997 Elsevier Science Ltd. All rights reserved
Calibration of Smooth Camera Models (2012)

Generic imaging models can be used to represent any camera. Current generic models are discrete and define a mapping between each pixel in the image and a straight line in 3D space. This paper presents a modification of the generic camera model that allows the simplification of the calibration procedure. The only requirement is that the coordinates of the 3D projecting lines are related by functions that vary smoothly across space. Such a model is obtained by modifying the general imaging model using radial basis functions (RBFs) to interpolate image coordinates and 3D lines, thereby allowing both an increase in resolution (due to their continuous nature) and a more compact representation. Using this variation of the general imaging model, we also develop a calibration procedure. This procedure only requires that a 3D point be matched to each pixel. In addition, not all the pixels need to be calibrated. As a result, the complexity of the procedure is significantly decreased. Normalization is applied to the coordinates of both image and 3D points, which increases the accuracy of the calibration. Results with both synthetic and real datasets show that the model and calibration procedure are easily applicable and provide accurate calibration results.
ROBUST PRINCIPAL COMPONENT ANALYSIS BY PROJECTION PURSUIT (1993)

Principal component analysis (PCA) is a widely used technique in chemometrics.The classical PCA method is,unfortunately,non-robust,since the variance is adopted as the objective function.In this paper,projection pursuit (PP) is used to carry out PCA with a criterion which is more robust than the variance.In addition,the generalized simulated annealing (GSA) algorithm is introduced as an optimization procedure in the process of PP calculation to guarantee the global optimum.The results for simulated data sets show that PCA via PP is resistant to the deviation of the error distribution from the normal one.The method is especially recommended for use in cases with possible outlier(s) existing in the data.
¿Virtualidad y creación? El vacío del ordenador en el diseño conceptual (2006)

El ordenador se ha incorporado a la practica de las disciplinas de diseno sin haber evaluado antes su impacto sobre la creatividad y la innovacion. Las herramientas informaticas que se utilizan en diseno se han tomado y siguen tomandose de otras disciplinas en las que se requiere mas precision y control sin tener en cuenta que el comienzo de la actividad creativa necesita mayores dosis de ambiguedad, abstraccion e impresicion. Este articulo plantea un nuevo enfoque del uso de la virtualidad dentro del proceso de diseno: se pone en tela de juicio la informatica actual y se sugieren nuevos metodos para incorporar el ordenador en el diseno enriqueciendo las herramientas manuales tradicionales sin imitarlas o simularlas.
Prevention of Ransomware Execution in Enterprise Environment on Windows OS: Assessment of Application Whitelisting Solutions (2018)

Application whitelisting software allows only examined and trusted applications to run on user's machine. Since many malicious files don't require administrative privileges in order for them to be executed, whitelisting can be the only way to block the execution of unauthorized applications in enterprise environment and thus prevent infection or data breach. In order to assess the current state of such solutions, the access to three whitelisting solution licenses was obtained with the purpose to test their effectiveness against different modern types of ransomware found in the wild. To conduct this study a virtual environment was used with Windows Server and Enterprise editions installed. The objective of this paper is not to evaluate each vendor or make recommendations of purchasing specific software but rather to assess the ability of application control solutions to block execution of ransomware files, as well as assess the potential for future research. The results of the research show the promise and effectiveness of whitelisting solutions.
Intestinal Permeability in Preterm Infants by Feeding Type: Mother's Milk Versus Formula (2009)

Preterm infant intestinal permeability was significantly decreased for those receiving human milk versus formula in a dose-related manner in the first postnatal month.
Long-term exposure to intranasal oxytocin in a mouse autism model (2014)

Oxytocin (OT) is a neuropeptide involved in mammalian social behavior. It is currently in clinical trials for the treatment of autism spectrum disorder (ASD). Previous studies in healthy rodents (prairie voles and C57BL/6J mice) have shown that there may be detrimental effects of long-term intranasal administration, raising the questions about safety and efficacy. To investigate the effects of OT on the aspects of ASD phenotype, we conducted the first study of chronic intranasal OT in a well-validated mouse model of autism, the BTBR T+ Itpr3tf/J inbred strain (BTBR), which displays low sociability and high repetitive behaviors. BTBR and C57BL/6J (B6) mice (N=94) were administered 0.8 IU/kg of OT intranasally, daily for 30 days, starting on day 21. We ran a well-characterized set of behavioral tasks relevant to diagnostic and associated symptoms of autism, including juvenile reciprocal social interactions, three-chambered social approach, open-field exploratory activity, repetitive self-grooming and fear-conditioned learning and memory, some during and some post treatment. Intranasal OT did not improve autism-relevant behaviors in BTBR, except for female sniffing in the three-chambered social interaction test. Male saline-treated BTBR mice showed increased interest in a novel mouse, both in chamber time and sniffing time, whereas OT-treated male BTBR mice showed a preference for the novel mouse in sniffing time only. No deleterious effects of OT were detected in either B6 or BTBR mice, except possibly for the lack of a preference for the novel mouse's chamber in OT-treated male BTBR mice. These results highlight the complexity inherent in understanding the effects of OT on behavior. Future investigations of chronic intranasal OT should include a wider dose range and early developmental time points in both healthy rodents and ASD models to affirm the efficacy and safety of OT.
Functional rescue of a bacterial dapA auxotroph with a plant cDNA library selects for mutant clones encoding a feedback‐insensitive dihydrodipicolinate synthase (2000)

Dihydrodipicolinate synthase (DHDPS; EC4.2.1.52) catalyses the first reaction of lysine biosynthesis in plants and bacteria. Plant DHDPS enzymes are strongly inhibited by lysine (I0.5 approximately 10 microM), whereas the bacterial enzymes are less (50-fold) or insensitive to lysine inhibition. We found that plant dhdps sequences expressing lysine-sensitive DHDPS enzymes are unable to complement a bacterial auxotroph, although a functional plant DHDPS enzyme is formed. As a consequence of this, plant dhdps cDNA clones which have been isolated through functional complementation using the DHDPS-deficient Escherichia coli strain encode mutated DHDPS enzymes impaired in lysine inhibition. The experiments outlined in this article emphasize that heterologous complementation can select for mutant clones when altered protein properties are requisite for functional rescue. In addition, the mutants rescued by heterologous complementation revealed a new critical amino acid substitution which renders lysine insensitivity to the plant DHDPS enzyme. An interpretation is given for the impaired inhibition mechanism of the mutant DHDPS enzyme by integrating the identified amino acid substitution in the DHDPS protein structure.
Image oversampling for page-oriented optical data storage (2006)

Page-oriented data storage systems incorporate optical detector arrays [such as complementary metal-oxide semiconductor (CMOS) arrays] in order to read data images. For laboratory demonstrations the detector array is typically pixel matched to the data image [Opt. Lett. 22, 1509 (1997)]. This approach requires exceedingly high-performance optics and mechanics for the simultaneous alignment of each data-bearing pixel image to a detector element to be achieved. Systems intended for commercialization are designed with detector arrays that spatially sample the image at or above the Nyquist rate in order to read poorly aligned and distorted images [S. Redfield, Holographic Data Storage (Springer-Verlag, 2000), pp. 347-349]. However, for data page sizes exceeding a megapixel this approach becomes prohibitive in terms of detector bandwidth, size, power, cost, and processing requirements. We have instead developed a sub-Nyquist oversampling methodology that can recover arbitrarily aligned and distorted megapixel data page images with pixel-matched fidelity by using fewer than double the number of detector pixels. Features required for practicable implementation are described, including fiducials for alignment determination.
Titelei/Inhaltsverzeichnis (2018)

Der Aufsichtsrat einer Aktiengesellschaft sieht sich angesichts zunehmender Professionalisierung seiner Tätigkeit stetig steigenden Anforderungen ausgesetzt. Um diesen gerecht werden zu können, benötigt er diverse Ressourcen – aus sich selbst heraus, aber auch in Form externer Unterstützung. Das Werk bietet eine praktische Orientierungshilfe ebenso wie einen rechtsdogmatischen Grundlagenbeitrag zu der Frage, wie der Aufsichtsrat an solche Leistungen gelangt. Dabei werden sowohl Unterstützungsleistungen von externen Anbietern als auch solche aus der vom Vorstand geleiteten Unternehmensorganisation beleuchtet. Hinsichtlich der Finanzierung solcher Leistungen werden neben der Steuerung konkreter Zahlungsvorgänge auch die Gestaltungsmöglichkeiten durch ein Budget für die Kosten des Aufsichtsrats untersucht. Schließlich wird der Auslagenersatz von Aufsichtsratsmitgliedern gesondert behandelt. Das Hauptaugenmerk liegt auf der Kompetenzverteilung zwischen Aufsichtsrat und Vorstand.
Digital Signal Processing for Short-Reach Optical Communications: A Review of Current Technologies and Future Trends (2018)

Driven primarily by cloud service and data-center applications, short-reach optical communication has become a key market segment and growing research area in recent years. Short-reach systems are characterized by direct detection-based receiver configurations and other low-cost and small form factor components that induce transmission impairments unforeseen in their coherent counterparts. Innovative signaling and digital signal processing (DSP) play a pivotal role in enabling these components to realize their ultimate potentials and meet data rate requirements in cost-effective manners. This paper presents an overview of recent DSP developments for short-reach communications systems and discusses future trends.
The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant (1996)

The apoE epsilon 4 allele is strongly associated with increased NPs, but not neocortical NFTs, in both AD and LBV.
Natural tannin extracts supplementation for COVID-19 patients (TanCOVID): a structured summary of a study protocol for a randomized controlled trial (2021)

The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
An efficient square-root algorithm for BLAST (2002)

Bell Labs Layered Space-Time (BLAST) is a scheme for transmitting information over a rich-scattering wireless environment using multiple receive and transmit antennas. The main computational bottleneck in the BLAST algorithm is a "nulling and cancellation" step, where the optimal ordering for the sequential estimation and detection of the received signals is determined. To reduce the computational cost of BLAST, we develop an efficient square-root algorithm for the nulling and cancellation step. The main features of the algorithm include efficiency: the computational cost is reduced by 0.7 M, where M is the number of transmit antennas, and numerical stability: the algorithm is division-free and uses only orthogonal transformations. In a 14 antenna system designed for transmission of 1 Mbit/s over a 30 kHz channel, the nulling and cancellation computation is reduced from 190 MFlops/s to 19 MFlops/s, with the overall computations being reduced from 220 MFlops/s to 49 MFlops/s. The numerical stability of the algorithm also make it attractive for implementation in fixed-point (rather than floating-point) architectures.
Energy expenditure and physical activity in Prader–Willi syndrome: Comparison with obese subjects (2006)

Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder characterized by hypotonia, suck and feeding difficulties, hypogonadism, small hands and feet, developmental delay, hyperphagia and early childhood obesity and a particular facial appearance. The obesity associated with PWS is the result of a chronic imbalance between energy intake and energy expenditure (EE) due to hyperphagia, decreased physical activity, reduced metabolic rate and an inability to vomit. EE is affected by body composition as well as exercise. Individuals with PWS have a lower lean body mass (LBM) compared with controls which may contribute to reduced basal level EE. To determine the relationship among body composition, activity levels and metabolic rates, dual energy X-ray absorptiometry (DEXA) and a whole-room respiration chamber were used to measure body composition, total EE (TEE), resting EE (REE), physical activity, and mechanical work (MW) during an 8 hr monitoring period. The chamber consisted of a live-in whole-room indirect calorimeter equipped with a force platform floor to allow simultaneous measurement of EE, physical activity, and work efficiency during spontaneous activities and standardized exercise. Participants with PWS (27 with 15q11-q13 deletion and 21 with maternal disomy 15 with an average age of 23 years) had significantly decreased TEE by 20% and reduced LBM compared to 24 obese subjects. Similarly, REE was significantly reduced by 16% in the individuals with PWS relative to the comparison subjects. Total MW performed during the 8 hr monitoring period was significantly reduced by 35% in the PWS group. The energy cost of physical activity is related to the duration, intensity and type of activity and the metabolic efficiency of the individual. After adjusting group differences in LBM by analysis of variance, TEE and REE were no longer different between the two groups. Our data indicate that there is a significant reduction of EE in individuals with PWS resulting from reduced activity but also from lower energy utilization due to reduced LBM which consists primarily of muscle.