gebhart/patrepeval huggingface dataset:
Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial (2012)

Increased tumor-associated macrophages (TAMs) are reported to be associated with poor prognosis in classic Hodgkin lymphoma (CHL). We investigated the prognostic significance of TAMs in the E2496 Intergroup trial, a multicenter phase 3 randomized controlled trial comparing ABVD and Stanford V chemotherapy in locally extensive and advanced stage CHL. Tissue microarrays were constructed from formalin-fixed, paraffin-embedded tumor tissue and included 287 patients. Patients were randomly assigned into training (n = 143) and validation (n = 144) cohorts. Immunohistochemistry for CD68 and CD163, and in situ hybridization for EBV-encoded RNA were performed. CD68 and CD163 IHC were analyzed by computer image analysis; optimum thresholds for overall survival (OS) were determined in the training cohort and tested in the independent validation cohort. Increased CD68 and CD163 expression was significantly associated with inferior failure-free survival and OS in the validation cohort. Increased CD68 and CD163 expression was associated with increased age, EBV-encoded RNA positivity, and mixed cellularity subtype of CHL. Multivariate analysis in the validation cohort showed increased CD68 or CD163 expression to be significant independent predictors of inferior failure-free survival and OS. We demonstrate the prognostic significance of TAMs in locally extensive and advanced-stage CHL in a multicenter phase 3 randomized controlled clinical trial.
One year of monitoring of the Type IIb supernova SN 2011dh (2013)

Optical $UBVRI$ photometry and low resolution spectroscopy of the type IIb supernova SN 2011dh in M51 are presented, covering the first year after the explosion. The light curve and spectral evolution are discussed. The early phase light curve evolution of SN 2011dh is very similar to SN 1993J and SN 2008ax. In the late phase, however, SN 2011dh declines faster than SN 1993J. The late phase decline in the $B$-band is steeper than in the $R$ and $I$ bands, indicating the possibility of dust formation. With a peak $V$-band absolute magnitude of $M_V = -17.123\pm0.18$ mag, SN 2011dh is a marginally faint type IIb event. The reddening corrected colour curves of SN 2011dh are found to be redder than other well studied type IIb supernovae. The bolometric light curve indicates $\sim$ 0.09 M$_\odot$ of $^{56}$Ni is synthesized during the explosion. The HeI lines were detected in the spectra during the rise to maximum. The nebular spectra of SN 2011dh show a box shaped emission in the red wing of the [OI] 6300-6363 \AA\ feature, that is attributed to H$\alpha$ emission from a shock excited circumstellar material. The analysis of nebular spectra indicates that $\sim 0.2$ M$_\odot$ of oxygen was ejected during the explosion. Further, the [CaII]/[OI] line ratio in the nebular phase is $\sim$ 0.7, indicating a progenitor with a main sequence mass of 10-15 M$_\odot$.
Preamble to Special Issue (2012)

About 15 years ago the City of Melbourne came up with a scheme that would transform completely the face and the fortunes of the city. At the time the city, like thousands of others around the globe, emptied at night as tens of thousands of commuters decamped in their cars for the suburbs. The Council's Postcode 3000 scheme, launched in 1992, outlined plans to entice residential development back into the city, through financial and technical incentives, technical advice, a review of technical requirements, research and statistical data, promotional events and publicity.It is hard now to believe -walking through the bustling streets lined with converted apartments and thriving businesses -that anyone was ever sceptical about the potential for city living Melbourne-style. The success of Postcode 3000 far exceeded even the most ambitious targets and the City of Melbourne became one of the fastest growing municipalities in the land.With its visionary new Council House 2 (CH2) building , the City of Melbourne is once again planning a lifestyle revolution. This time the subject is sustainability and the target is the construction industry. Using the CH2 office building as a living , breathing example, the Council intends to demonstrate the potential for sustainable technologies to transform the way we approach the design, construction and indeed entire philosophy of our built environment. Just as Postcode 3000 reinvented the city, the City of Melbourne wants to see the CH2 example copied , improved upon and enthusiastically taken up throughout Melbourne and far, far beyond.As before, there are a great many sceptics. The City's approach to this has been to patiently press ahead with construction of its best source of proof -CH2 itself -while actively and energetically encouraging lively debate -from the greatest enthusiasts to the harshest critics alike.
A 79-GHz Scalable FMCW MIMO Automotive Radar Transceiver Architecture with Injection-Locked Synchronization (2019)

This paper describes a 79 GHz four transmit, four receive channels automotive frequency modulated continuous wave multi-input-multi-output radar integrated circuit based on 20 GHz injection lock oscillator (ILO). The proposed architecture enables the cascading of multiple transceiver (TRX) chips in a daisy chained manner where each TRX chip is injection locked to the previous one. System architecture and circuit design of ILO has been described in detail with the measurement results.
Remote downconversion with wavelength reuse for the radio/fiber uplink connection (2006)

The authors present a novel technology for uplink transmission in radio-over-fiber distribution systems. The technique employs remote downconversion of the uplink data to intermediate frequency (IF) in the base station (BS). The local oscillator signal for the downconversion is optically generated in the central station (CS) and sent to the BS via optical fiber. The IF uplink data is then modulated onto an optical carrier, retrieved from the downlink signal, and sent to the CS, where the baseband conversion takes place. By employing this method of uplink connection, simplicity and cost efficiency of the BS is achieved
AUTISM AS A PARADIGMATIC COMPLEX GENETIC DISORDER (2004)

Autism is one of the most heritable complex disorders, with compelling evidence for genetic factors and little or no support for environmental influence. The estimated prevalence of autism has increased since molecular genetic studies began, owing to loosening of diagnostic criteria and, more importantly, to more complete ascertainment strategies. This has led to a reduction in the sibling relative risk, but strong heritability estimates remain. It is essential to recognize that genetics is the only current approach to understanding the pathophysiology of autism in which there is not the usual concern about whether one is studying a consequence rather than a cause. There are hundreds, if not thousands, of patients with autism spectrum disorder with documented single-gene mutations or chromosomal abnormalities. Autism may be one of the most complex, yet strongly genetic, disorders in which chromosomal disorders, relatively rare highly penetrant mutations, and multiplicative effects of common variants all have support in different cases and families. The field of complex genetics is replete with many researchers and reviewers who want to promote their overly focused interest in one method at the exclusion of others. However, it is essential that the restricted interests of patients with autism not be reflected in overly restrictive genetic approaches if we are to better understand the genetics of autism in the most expeditious and thorough manner.
Different Protein Kinase C Isoforms Determine Growth Factor Specificity in Neuronal Cells (2000)

Although mitogenic and differentiating factors often activate a number of common signaling pathways, the mechanisms leading to their distinct cellular outcomes have not been elucidated. In a previous report, we demonstrated that mitogen-activated protein (MAP) kinase (ERK) activation by the neurogenic agents fibroblast growth factor (FGF) and nerve growth factor is dependent on protein kinase Cdelta (PKCdelta), whereas MAP kinase activation in response to the mitogen epidermal growth factor (EGF) is independent of PKCdelta in rat hippocampal (H19-7) and pheochromocytoma (PC12) cells. We now show that EGF activates MAP kinase through a PKCzeta-dependent pathway involving phosphatidylinositol 3-kinase and PDK1 in H19-7 cells. PKCzeta, like PKCdelta, acts upstream of MEK, and PKCzeta can potentiate Raf-1 activation by EGF. Inhibition of PKCzeta also blocks EGF-induced DNA synthesis as monitored by bromodeoxyuridine incorporation in H19-7 cells. Finally, in embryonic rat brain hippocampal cell cultures, inhibitors of PKCzeta or PKCdelta suppress MAP kinase activation by EGF or FGF, respectively, indicating that these factors activate distinct signaling pathways in primary as well as immortalized neural cells. Taken together, these results implicate different PKC isoforms as determinants of growth factor signaling specificity within the same cell. Furthermore, these data provide a mechanism whereby different growth factors can differentially activate a common signaling intermediate and thereby generate biological diversity.
Intratracheal Instillation Methods and the Distribution of Administered Material in the Lung of the Rat (2014)

Intratracheal instillation is widely used for respiratory toxicity tests in experimental animals. However, there are wide variations in the techniques used for instillation, and it is thus difficult to compare the results obtained using different techniques. To examine the effect of instillation methods, we compared the distribution of a test substance in the lungs of rats after intratracheal instillations under various conditions. Rats received an intratracheal instillation of 0.3 mL of india ink suspension under different conditions as follows: 3 different angles of body restraint, 0° (supine horizontal), 45° (supine head up) and 90° (vertical head up); 2 instillation speeds, high (40 mL/min) and low (4 mL/min); and 2 different devices, a standard bulb-tipped gavage needle and an aerosolizing microsprayer designed for intratracheal instillation. One hour after treatment under these various conditions, rats were sacrificed, and the local distribution of the suspension in the lungs was observed. No animal restrained in the supine head-up or vertical head-up position died from the treatment; however, fatalities were observed when rats were restrained in the supine horizontal position except under high-speed dosing conditions with a microsprayer. Better distribution of the suspension in the lungs was observed in the rats restrained in the supine head-up position after instillation at high speed when compared with other conditions. These results indicated that high-speed instillation to the subject restrained in the supine head-up position is an appropriate condition for performing intratracheal instillation.
Structure and characterization of the mouse UT-A gene (<i>Slc14a2</i>) (2002)

The movement of urea across plasma membranes is modulated by facilitated urea transporter proteins. These proteins are the products of two closely related genes, termed UT-A (Slc14a2) and UT-B (Slc14a1). By genomic library screening and P1 artificial chromosome "shotgun" sequencing, we have determined the structure of the mouse UT-A gene. The gene is >300 kb in length, contains 24 exons, and has 2 distinct promoters. Flanking the 5'-region of the gene is the UT-Aalpha promoter that regulates transcription of UT-A1 and UT-A3. The second promoter, termed UT-Abeta, is present in intron 13 and regulates transcription of UT-A2. cAMP agonists (100 microM dibutryl cAMP, 25 microM forskolin, 0.5 mM IBMX) increased the activity of a 2.2-kb UT-Aalpha promoter construct 6.2-fold [from 0.026 +/- 0.003 to 0.160 +/- 0.004, relative light units (RLU)/microg protein] and a 2.4-kb UT-Abeta promoter construct 9.5-fold (from 0.020 +/- 0.002 to 0.190 +/- 0.043 RLU/microg protein) above that in untreated controls. Interestingly, only the UT-Abeta promoter contained consensus sequences for CREs and deletion of these elements abolished cAMP sensitivity. Increasing the tonicity of culture medium from 300 to 600 mosmol/kg H(2)O with NaCl caused a significant increase (from 0.060 +/- 0.004 to 0.095 +/- 0.010 RLU/microg protein) in UT-Aalpha promoter activity but had no effect on the UT-Abeta promoter. A tonicity-responsive enhancer was identified in UT-Aalpha and is suggested to be responsible for mediating this effect. Levels of UT-A2 and UT-A3 mRNA were increased in thirsted mice compared with control animals, indicating that the activities of both promoters are likely to be elevated during prolonged antidiuresis.
Unsupervised Video-to-Video Translation (2018)

Unsupervised image-to-image translation is a recently proposed task of translating an image to a different style or domain given only unpaired image examples at training time. In this paper, we formulate a new task of unsupervised video-to-video translation, which poses its own unique challenges. Translating video implies learning not only the appearance of objects and scenes but also realistic motion and transitions between consecutive frames.We investigate the performance of per-frame video-to-video translation using existing image-to-image translation networks, and propose a spatio-temporal 3D translator as an alternative solution to this problem. We evaluate our 3D method on multiple synthetic datasets, such as moving colorized digits, as well as the realistic segmentation-to-video GTA dataset and a new CT-to-MRI volumetric images translation dataset. Our results show that frame-wise translation produces realistic results on a single frame level but underperforms significantly on the scale of the whole video compared to our three-dimensional translation approach, which is better able to learn the complex structure of video and motion and continuity of object appearance.
Single-Frequency External Cavity Green Diode Laser (2017)

We present a design of a single-frequency green InGaN external cavity diode laser (ECDL) with 40-mW output power and 10-MHz linewidth. The ECDL was mounted in the Littrow configuration, with an overall efficiency of approximately 52% and a tuning region of 8 nm. We analyzed the output efficiency of the ECDL under different polarization directions and emitted light patterns. We used a spectrometer to analyze the laser spectrum under the different applied currents and temperatures. Finally, we obtained the linewidth of the ECDL using a scanning Fabry-Perot interferometer and found that the linewidth varied with the wavelength.
A Comprehensive and Hierarchical Ontology for Wireless Systems (2014)

Abstract—This paper presents a comprehensive radio ontology. The ontology describes the communication/networking scenario, the RF devices, their components and protocols that they support, the policies, and the tasks to be performed. The developed ontology enables wireless Software-Defined Networks (SDN) composed of abstract heterogeneous Radio Frequency (RF) devices. Index Terms — ontology, cognitive radio, reconfigurability, software-defined networking, protocols I.
Effects of Size of Carbohydrate Chain on Protease Digestion of<i>Aspergillus niger</i>Endo-<i>β</i>-1,4-glucanase (1995)

Three different carbohydrate-depleted enzymes were prepared from an endo-beta-1,4-glucanase of Aspergillus niger IFO31125 by treatment with endo-beta-N-acetylglucosaminidase or alpha-mannosidase. They were purified by Concanavalin A-Sepharose affinity and DEAE ion-exchange column chromatographies. The molecular sizes of these enzymes had been decreased from 40 kDa containing 9.0% carbohydrate to 39, 38, and 37 kDa with carbohydrate at 4.5, 1.3, and 0.8% (wt/wt), respectively. The native and these carbohydrate-depleted enzymes were compared in their enzymatic properties, and it was found that they were identical in their catalytic activities and both thermal and pH stabilities. However, the 37-kDa enzyme was more susceptible to proteolysis by Savinase, proteinase K, and Pronase E. On the other hand, the specific protease trypsin showed no such effect on activity of all enzymes. These results suggested that the core structure of the asparagine-linked sugar chain, which consisted of three monosaccharide residues, contributed to the high stability of the endo-beta-1,4-glucanase against protease digestion.
What is the Economics of Climate Change (2006)

A major review of the economics of climate change under the leadership of Professor Sir Nicholas Stern was announced at the end of July 2005, reporting to the United Kingdom's Chancellor of the Exchequer and to the Prime Minister. The Stern Review on the Economics of Climate Change is due to report in autumn 2006. This article sets out some of the issues the review is considering.
Range-Doppler ambiguity mitigation via closed-loop, adaptive PRF selection (2010)

In this paper, we present a method of calculating and updating target probabilities in ambiguous range-Doppler cells along with an adaptive pulse repetition frequency (PRF) selection technique based on mutual information (MI). We approach the problem of updating the probability in multiple ambiguous cells by using a multiple hypothesis test for the target state. The probability ensemble is then used to determine which PRF will maximize MI on the next update. Since MI is a measure of the reduction in entropy of the ensemble, it indicates the amount of information the radar stands to learn about the channel due to the selected PRF. We compare the results of MI-based PRF selection to two other PRF selection methods and demonstrate how blind zones and clutter aliasing can be seamlessly integrated into our PRF-selection procedure.
A Raster Image Re-Projection Web Service Prototype (2004)

A prototyping effort pertaining to the design and development of a raster image re-projection web service is summarized. The goal of the effort is to identify the complexities of interoperable service design and the feasibility of service chaining in a GIS Web Services architecture. A description of a preliminary web interface and the implementation options considered for the prototype are described. The experience of chaining this service with the Open GIS Consortium (OGC) Web Mapping Services is also summarized. In the process, the difficulties arising from the lack of standards in the areas of projection systems representation and georectified raster imagery encodings are highlighted. The limitations of legacy GIS systems in accommodating the requirements of a generic reprojection service are also discussed. Lessons learned about basic requirements for efficient service chaining are presented in the areas of performance and reliability of services, ease of access to services and their capabilities, and the need for simple solutions.
IgG Charge (2018)

It has been known since the 1930&rsquo;s that all immunoglobulins carry a weak negative charge in physiological solvents. However, there has been no systematic exploration of this fundamental property. Accurate charge measurements have been made using membrane confined electrophoresis in two solvents (pH 5.0 and pH 7.4) on a panel of twelve mAb IgGs, as well as their F(ab&rsquo;)2 and Fc fragments. The following observations were made at pH 5.0: 1) the measured charge differs from the calculated charge by ~40 for the intact IgGs, and by ~20 for the Fcs; 2) the intact IgG charge depends on both Fv and Fc sequences, but does not equal the sum of the F(ab)&rsquo;2 and Fc charge; 3) the Fc charge is consistent within a class. In phosphate buffered saline, pH 7.4: 1) the intact IgG charges ranged from 0 to -13; 2) the F(ab&rsquo;)2 fragments are nearly neutral for IgG1s and IgG2s, and about -5 for some of the IgG4s; 3) all Fc fragments are weakly anionic, with IgG1 &lt; IgG2 &lt; IgG4; 4) the charge on the intact IgGs does not equal the sum of the F(ab&rsquo;)2 and Fc charge. In no case is the calculated charge, based on H+ binding, remotely close to the measured charge. The charge on IgGs in physiological solvent is sufficiently small to minimize its contribution to thermodynamic nonideality. Some of the mAbs carried a charge in physiological salt that was outside the range observed for serum-purified human poly IgG. To best match physiological properties, a therapeutic mAb should have a measured charge that falls within the range observed for serum-derived human IgGs.
Learning Aided Behavioral Modeling and Adaptive Digital Predistortion Design for Nonlinear Power Amplifier (2016)

A new learning-based structure is defined for the identification of nonlinear attributes of a baseband power amplifier (PA) and design of an adaptive digital pre-distorter for application in wireless channels. Analytically and experimentally, generalized memory polynomial (GMP) model is derived from the transmit-receive conditions and the learning network structure. The test data are a sequences of 16-quadrature amplitude modulation (QAM) and 64-QAM complex symbols. In simulation, unknown GMP models of different order are used as a baseband PA model for identification. Minicircuits ZHL-4240 radio frequency PA modules along with NI USRP 2920 units are employed for experimental verification of the concept. The learning aspect is governed by a specially designed artificial neural network structure called real valued focused time delay neural network. Simulation and empirical results agree with analytical derivation.
XCHOKe: malicious source control for congestion avoidance at Internet gateways (2003)

The paper describes an algorithm to control flows from nonadaptive sources in the Internet in a simple and lightweight fashion. The algorithm, called XCHOKe, is an extension to CHOKe and RED. The paper presents experimental results from simulations that demonstrate that the algorithm outperforms current well-known algorithms for buffer management in providing better protection for TCP flows under varying degrees of attack from non-adaptive flows.