gebhart/patrepeval huggingface dataset:
Deployment cost efficiency in broadband delivery with fixed wireless relays (2006)

Although radio repeaters and wireless routers are commonly used, relaying techniques have received a lot of attention in academic publications the last decade. Most of the techniques proposed in the literature are based on relaying terminals. For instance groups of mobile terminals cooperate so as to jointly communicate with an access point, or to another group of mobiles in an (infrastructure-less) mobile ad-hoc network MANET. However, it has also been suggested that these techniques can be applied to hybrid cellular-relaying architecture with fixed relays and that this would reduce the infrastructure costs. The literature shows that the coverage or capacity of a cellular network is enhanced when using relays. A common assumption in these studies is that relays are very low cost, but little attention has been given to how cheap these relays need to be in order for the technical enhancements to translate into an economic gain. It is not obvious that the techniques proposed for mobile relaying are economically feasible when applied to fixed relays. This thesis examines the conditions under which large scale usage of fixed relays leads to lower infrastructure cost than in a purely cellular architecture, how large the benefits of these new techniques are, compared with existing repeater/router techniques, and how sensitive the results are to traditional network design parameters. The analysis is done by means of several study cases in which coverage should be provided for broadband services by building a network from scratch. The results are expressed in terms of how cheap a relay must be with respect to a base station's cost so that the hybrid infrastructure provides the desired service at a lower cost. If in practice this relative relay cost is much lower, then high economic gains are expected. None of the study cases considered yield substantial cost savings when using fixed relays on a large scale. When access points are placed as high as in a cellular network, the hybrid system is feasible only if the total relay cost is 3-20% of the total base station cost. When unplanned relay deployment is used, the impact of the antenna height and/or gain on the results is much greater than the particular type of amplify-and-forward relaying scheme. Planned deployment of a few relays should be used unless the cost of planning is 1-2 times larger than all the other relay costs. A proper trade-off between route-length and how tight the radio channel can be reused is essential for the feasibility of the hybrid system. The results confirm that the planned usage of few relays together with macro-like base stations is an efficient way of providing coverage. Analysis of other scenarios, such as the use of pico base stations for coverage, is left for further studies.
Coriacenins:  A New Class of Long Alkyl Chain Amino Alcohols from the Mediterranean Sponge <i>Clathrina coriacea</i> (1996)

The Mediterranean sponge Clathrina coriacea contains a series of long chain amino alcohols, named coriacenins (2−6), belonging to a new class of alkaloids. The structures of the novel compounds were elucidated by studying, with a combination of spectral and chemical methods, their peracetyl derivatives (2a−6a). Coriacenins are characterized by a bis(1,3-diamino-2-propanol) moiety and a linear alkyl chain varying both by length and by degree of unsaturation. The biosynthetic pathway leading to coriacenins seems to be unprecedented. It should, however, occur through condensation of an acetogenin with an uncommon amino acid.
Roles of mitochondria in neuronal development (2018)

Mitochondria are ubiquitous and multi-functional organelles involved in diverse metabolic processes, namely energy production and biomolecule synthesis. The intracellular mitochondrial morphology and distribution change dynamically, which reflect the metabolic state of a given cell type. A dramatic change of the mitochondrial dynamics has been observed in early development that led to further investigations on the relationship between mitochondria and the process of development. A significant developmental process to focus on, in this review, is a differentiation of neural progenitor cells into neurons. Information on how mitochondria- regulated cellular energetics is linked to neuronal development will be discussed, followed by functions of mitochondria and associated diseases in neuronal development. Lastly, the potential use of mitochondrial features in analyzing various neurodevelopmental diseases will be addressed. [BMB Reports 2018; 51(11): 549-556].
A Novel Approach to Tumor Suppression with Microencapsulated Recombinant Cells (2002)

A novel approach to cancer gene therapy is to implant microcapsules containing nonautologous cells engineered to secrete molecules with antineoplastic properties. The efficacy of this treatment is now tested in a mouse model bearing HER-2/neu-positive tumors. Nonautologous mouse myoblasts (C(2)C(12)) were genetically modified to secrete interleukin-2 linked to the Fv region of a humanized antibody with affinity to HER-2/neu. The resulting fusion protein, sFvIL-2, would encompass immune-stimulatory cytokine activity now targeted to the HER-2/neu-expressing tumor. These recombinant cells were then immunoprotected with alginate-poly-L-lysine-alginate microcapsules before implantation into tumor-bearing mice. Treatment with these encapsulated cells led to a delay in tumor progression and prolonged survival of the animals. The long-term efficacy was limited by an inflammatory reaction against the implanted microcapsules probably because of the secreted cytokine and antigenic response against the xenogeneic fusion protein itself. However, over the short term (initial 2 weeks), efficacy was confirmed when a significant amount of biologically active interleukin-2 was detected systemically, and targeting of the fusion protein to the HER-2/neu-expressing tumor was shown immunohistochemically. The tumor suppression in the treated animals was associated with increased apoptosis and necrosis in the tumor tissue, thus demonstrating successful targeting of the antiproliferative effect to the tumors by this delivery paradigm. In conclusion, this new approach to systemic cancer gene therapy needs to be modified to provide long-term delivery, but has demonstrated short-term efficacy and potential to become a cost-effective, benign, and non-viral-based adjunct to the current armory of anticancer strategies.
Triple-Helical Structure of(1→3)-β-D-Glucan (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTriple-Helical Structure of(1→3)-β-D-GlucanY. Deslandes, R. H. Marchessault, and A. SarkoCite this: Macromolecules 1980, 13, 6, 1466–1471Publication Date (Print):November 1, 1980Publication History Published online1 May 2002Published inissue 1 November 1980https://pubs.acs.org/doi/10.1021/ma60078a020https://doi.org/10.1021/ma60078a020research-articleACS PublicationsRequest reuse permissionsArticle Views1139Altmetric-Citations240LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Patchy Particle Self-Assembly via Metal Coordination (2013)

Colloids with high-symmetry patches are functionalized with metal-coordination-based recognition units and assembled into larger chain architectures, demonstrating for the first time the use of metal coordination as a specific force in colloidal self-assembly. The cross-linked poly(styrene)-based patchy particles are fabricated by encapsulation of colloidal clusters following a two-stage swelling and polymerization methodology. The particle patches, containing carboxylic acid groups, are site-specifically functionalized either with a triblock copolymer (TBC), bearing primary alcohols, alkyl chains, and palladated pincer receptors, synthesized by ring-opening metathesis polymerization, or with a small molecule bearing a pyridine headgroup. Functionalizing with a TBC provides design flexibility for independently setting the range of the interaction and the recognition motif.
The 3d Parameters Of A (Nano)Crystal From Lattice Images At Two Tilts (1999)

Abstract Various techniques have been developed to infer the 3D relationship of reciprocal lattice vectors from electron diffraction patterns taken at different specimen orientations. Such relationship is subsequently applied in crystallographic analyses. Due to the transmitted nature of the electron beam, TEM images present 3D information averaged throughout the thickness of the specimen on each micrograph. Techniques for acquiring 3D information from such images include stereomicroscopy for characterizing irregular dislocation networks, and 3D reconstruction of nonperiodic macromolecular assemblies. Prospects for finding the 3D lattice parameters of nanocrystals from HREM images taken at different specimen orientations have been discussed. Here we apply this stereo lattice imaging to a 7 nm crystal, and discuss its application to compact fee and bec lattices in general. Results on other lattice types will be published separately. Generally 3 non-coplanar lattice vectors seen along 2 different zone axes are sufficient for inferring a subset of the 3D reciprocal lattice of a single crystal.
Immunochemical characterization of the platelet-specific alloantigen Leka: a comparative study with the PlA1 alloantigen (1984)

We report the immunochemical characterization of a new platelet- specific alloantigen detected using an IgG antibody isolated from the serum of a patient with posttransfusion purpura (PTP). In indirect immunoprecipitation experiments, the antibody, termed anti-Leka, predominantly precipitated glycoprotein (GP) IIb from Triton X-100 lysates of normal human platelets. In an immunoblot procedure, which involved the transfer of platelet polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to nitrocellulose membrane, anti-Leka bound exclusively to GP IIb. Under identical conditions, four anti-PlA1 antibodies each reacted with GP IIIa. No binding of anti-Leka IgG occurred to Leka (-) platelets or to their separated polypeptides although GP IIb was normally detected by Coomassie blue staining. After electrophoresis of reduced platelet proteins, the Leka determinant was localized to the IIb alpha chain. Thus, unlike the PlA1 antigen, the Leka determinant was not destroyed by disulfide reduction. Analysis of platelets from a patient with Glanzmann's thrombasthenia revealed little or no binding in the GP IIb position. Anti-Leka permitted the identification of 76,000 and 60,000 dalton fragments of GP IIb retained by the platelet following chymotrypsin treatment. Our results further highlight the immunogenicity of the GP IIb-IIIa complex. They also suggest that antibodies against GP IIb can cause the thrombocytopenia observed in PTP and that anti-PlA1 antibodies do not account exclusively for the pathophysiology of this immune disorder.
An economical scan design for sequential logic test generation (2003)

A method of partial scan design in which the selection of scan flip-flops is aimed at breaking up the cyclic structure of the circuit is presented. Experimental data are given to show that the test generation complexity may grow exponentially with the length of the cycles in the circuit. This complexity grows only linearly with sequential depth. Graph-theoretic algorithms are presented to select a minimal set of flip-flops for eliminating cycles to reduce sequential depth. Tests for the resulting circuit can be efficiently generated by a sequential logic test generator. An independent control of the scan clock allows the insertion of scan sequences within the vector sequence produced by the test generator. Experimental results on a 5000 gate circuit show that a test coverage above 98% could be obtained by scanning just 5% of the flip-flops. In addition, the authors give the design of a scan flip-flop to reduce the input pin and signal routing overheads in a single-clock design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Signaling to NF- B: Regulation by Ubiquitination (2009)

The NF-kappaB pathway is a ubiquitous stress response that activates the NF-kappaB family of transcription factors. Antigen receptors, receptors of the innate immune system, and certain intracellular stressors are potent activators of this pathway. The transcriptional program that is activated is both antiapoptotic and highly proinflammatory. Indeed, any compromise in engagement of the pathway results in immunodeficiency, whereas constitutive activation generates a sustained inflammatory response that may promote malignancy. As such, NF-kappaB activation is under tight regulation by a number of post-translational modifications, including phosphorylation and ubiquitination. This article attempts to synthesize our current knowledge regarding the regulation of NF-kappaB signaling by ubiquitination, specifically highlighting the biochemical basis for both positive and negative feedback loops that function in unison to generate coordinated signals that are essential for the viability of metazoan animals.
Safety Evaluation of Two Probiotic Bifidobacterial Strains, <i>Bifidobacterium breve</i> M-16V and <i>Bifidobacterium infantis</i> M-63, by Oral Toxicity Tests Using Rats (2009)

The safety of two probiotic bifidobacterial strains, Bifidobacterium breve M-16V and Bifidobacterium infantis M-63, was evaluated by single dose and 90-day repeated dose oral toxicity tests using rats. In the single dose oral toxicity test using 1.4 × 1012 CFU/kg of B. breve M-16V or 3.2 × 1011 CFU/kg of B. infantis M-63, there were no death and no abnormalities. In the 90-day repeated dose oral toxicity test using 2.3 × 1011 CFU/kg/day of B. breve M-16V or 7.6 × 1010 CFU/kg/day of B. infantis M-63, no death and no abnormalities in body weight, food consumption, water consumption, urinalysis, hematology, blood biochemistry, organ weights, and histophathological findings were observed. The acceptable daily intake (ADI) of B. breve M-16V was calculated to be 1.38 × 1011 CFU/day for an adult weighing 60 kg and 1.15 × 1010 CFU/day for an infant weighing 5,000 g. Based on the findings of the present study together with the taxonomy and distribution data, as well as clinical experience in preterm infants, B. breve M-16V may be considered as extremely safe for consumption by humans including infants. Although B. infantis M-63 was considered as safe as B. breve M-16V, further confirmation by clinical investigations may be required.
Development of Patient Status-Based Dynamic Access System for Medical Information Systems (2015)

Recently, the hospital information system environment using IT communication technology and utilization of medical information has been increasing. In the medical field, the medical information system only supports the transfer of patient information to medical staff through an electronic health record, without information about patient status. Hence, it needs a method of real-time monitoring for the patient. Also, in this environment, a secure method in approaching healthcare through various smart devices is required. Therefore, in this paper, in order to classify the status of the patients, we propose a dynamic approach of the medical information system in a hospital information environment using the dynamic access control method. Also, we applied the symmetric method of AES (Advanced Encryption Standard). This was the best encryption algorithm for sending and receiving biological information. We can define usefulness as the dynamic access application service based on the final result of the proposed system. The proposed system is expected to provide a new solution for a convenient medical information system.
An Efficient Mixed-Signal 2.4-GHz Polar Power Amplifier in 65-nm CMOS Technology (2011)

A 65-nm digitally modulated polar transmitter incorporates a fully integrated, efficient 2.4-GHz switching Inverse Class-D power amplifier. Low-power digital filtering on the amplitude path helps remove spectral images for coexistence. The transmitter integrates the complete LO distribution network and digital drivers. Operating from a 1-V supply, the PA has 21.8-dBm peak output power with 44% efficiency. Simple static predistortion helps the transmitter meet EVM and mask requirements of 802.11g 54-Mb/s WLAN data with 18% average efficiency.
Improved methodology for the detection and quantification of the acrosome reaction in mouse spermatozoa. (2009)

This study evaluates the use of two fluorescein-labelled (FITC) plant lectins, Pisum sativum (edible pea) agglutinin (PSA) and Arachis hypogaea (peanut) agglutinin (PNA), in order to determine the most accurate and reliable method to experimentally detect and assess the acrosome reaction in mouse spermatozoa. PNA-FITC labelling was restricted to the acrosome and was not influenced by the fixation procedure; either absolute methanol or paraformaldehyde. In contrast, PSA-FITC not only labelled the acrosome, but also the whole head and the flagellum. This aspect was especially marked after methanol fixation. The cytoplasmic droplet, when present, was also stained by PSA-FITC. Incubation with the calcium ionophore ionomycin induced a concentration and time-dependent increase in the number of acrosome reactions. Compared to spotted preparations, smear samples exhibited a high proportion of spermatozoa with damaged acrosome. In conclusion, PNA-FITC labelling was more accurate than PSA-FITC labelling to detect the acrosome of mouse spermatozoa. The fixation method (methanol vs. paraformaldehyde) had no influence on the staining pattern of PNA-FITC labelling, but spotted preparations are recommended to avoid mechanical damage to the acrosome. Ionophore challenge confirmed the existence of a calcium-dependent acrosome reaction in mouse spermatozoa and validated the use of PNA-FITC to quantify this physiological process. The present study illustrates important methodological considerations which need to be taken into account in order to design a reliable and reproducible protocol for the study of the acrosome reaction.
Glass fiber reinforcement in repaired acrylic resin removable dentures: preliminary results of a clinical study. (1997)

The clinical usefulness of continuous E-glass partial fiber reinforcement of acrylic resin removable dentures was evaluated an average 13 months after the insertion of the fibers. Twelve removable complete dentures and ten removable partial dentures with a history of recurrent fracture were selected for this study. The partial fiber reinforcement was incorporated into the denture at the time of repair. One complete denture and one removable partial denture fractured in the region of reinforcement during the examination period. These fractures were most likely caused by faulty placement of the fiber reinforcement in the denture in the dental laboratory. In six dentures, new fractures occurred in regions without partial fiber reinforcement. The results revealed the importance of both the correct positioning of the partial fiber reinforcement in the denture and the use of accurate laboratory techniques.
Flexible Low Cost Lane Departure Warning System (2007)

<div class="htmlview paragraph">Many highway accidents are caused by distracted drivers and those suffering from drowsy driver syndrome. A driver alert indicating a lane departure could thwart such accidents, saving lives and making our roads safer.</div> <div class="htmlview paragraph">Products called Lane Departure Warning Systems (LDWS) have been developed to alert drivers of a lane departure. However, due to their high cost, lane departure warning systems are available only on luxury vehicles, barring their benefits from the majority of drivers. With Field Programmable Gate Arrays (FPGA) becoming more powerful and more affordable, a LDWS implementation utilizing hardware rather than software to conduct image processing eliminates the need for a costly high-power microprocessor, and could bring LDWS to a broader user base.</div> <div class="htmlview paragraph">This paper will discuss an FPGA based approach to LDWS. The proof-of-concept system is based on a Xilinx FPGA, taking its image data from an off-the-shelf NTSC camera. This implementation leverages the massively parallel nature of the FPGA to produce a high performance system that could be developed into a low-cost commercial LDWS.</div> <div class="htmlview paragraph">The proof-of-concept system detected lane departures with a detection accuracy of 74%. With the low cost of FPGA-based designs, lane departure warning systems could become profitable on more automobile models, thus increasing their availability.</div>
In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L (2014)

Histone lysine methylation has a pivotal role in regulating the chromatin. Histone modifiers, including histone methyl transferases (HMTases), have clear roles in human carcinogenesis but the extent of their functions and regulation are not well understood. The NSD family of HMTases comprised of three members (NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L) are oncogenes aberrantly expressed in several cancers, suggesting their potential to serve as novel therapeutic targets. However, the substrate specificity of the NSDs and the molecular mechanism of histones H3 and H4 recognition and methylation have not yet been established. Herein, we investigated the in vitro mechanisms of histones H3 and H4 recognition and modifications by the catalytic domain of NSD family members. In this study, we quantified in vitro mono-, di- and tri- methylations on H3K4, H3K9, H3K27, H3K36, H3K79, and H4K20 by the carboxyl terminal domain (CTD) of NSD1, NSD2 and NSD3, using histone as substrate. Next, we used a molecular modelling approach and docked 6-mer peptides H3K4 a.a. 1-7; H3K9 a.a. 5-11; H3K27 a.a. 23-29; H3K36 a.a. 32-38; H3K79 a.a. 75-81; H4K20 a.a. 16-22 with the catalytic domain of the NSDs to provide insight into lysine-marks recognition and methylation on histones H3 and H4. Our data highlight the versatility of NSD1, NSD2, and NSD3 for recognizing and methylating several histone lysine marks on histones H3 and H4. Our work provides a basis to design selective and specific NSDs inhibitors. We discuss the relevance of our findings for the development of NSD inhibitors amenable for novel chemotherapies.
The effect of user features on churn in social networks (2011)

Social sites and services rely on the continuing activity, good will and behaviour of the contributors to remain viable. There has been little empirical study of the mechanisms by which social sites maintain a viable user base. Such studies would provide a scientific understanding of the patterns that lead to user churn (i.e. users leaving the community) and the community dynamics that are associated with reduction of community members -- primary threats to the sustainability of any service. In this paper, we explore the relation between a user's value within a community - constituted from various user features - and the probability of a user churning.