gebhart/patrepeval huggingface dataset:
Exploring New Molecules and Activities from <i>Lonomia obliqua</i> Caterpillars (2005)

Skin contact with Lonomia caterpillar bristles causes a consumptive coagulopathy. From a cDNA library we cloned and expressed a prothrombin activator (rLopap) in active form, and from the bristles extract we characterized a FX activator (Losac). Several clones were sequenced and analyzed by expressed sequence tags. A database of about 1,270 sequences was constructed and deposited in NCBI (CX815710-CX817210) [corrected] Both the native protein from the venom (Lopap) and the recombinant form (r-Lopap) promoted prothrombin hydrolysis, generating prethrombin-2, F1.2 and thrombin. Losac is a single-chain (43 kDa) protein that cleaves the FX heavy chain producing FXaalpha. In HUVECs rLopap and Losac are able to modulate cell survival by preventing apoptosis. rLopap increases NO and PGI2 concentration and Losac induces t-PA expression. Finally, to identify the venom proteins related to human envenomation, a 2D electrophoresis map is being performed as an attempt to find the major toxins recognized by the anti-lonomia venom.
A collaborative speech enhancement approach for speech recognition in motorcycle environment (2009)

Aiming at the optimization of the speech recognition performance, we investigate various configurations for a speech front-end, which is part of a multimodal dialogue interaction interface of a wearable solution for information support of the motorcycle police force on the move. Initially, the practical value of various speech enhancement techniques is assessed, and subsequently a collaborative scheme employing independent speech enhancement channels, which operate in parallel on a common input, is proposed. It was experimentally found that the Adaboost.M1 algorithm is the most advantageous among a number of fusion methods. The improvement of speech recognition accuracy due to the collaborative speech enhancement scheme is expressed as gain of 8% in terms of word recognition rate, when compared to the performance of the best speech enhancement channel, alone.
Map of the British Isles (2007)

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[The research of thrombolytic and hemolysis effect from Eupolyphage fibrinolyric protein and its inhibitory effect on S180 ascites tumor of mice]. (2010)

EFP has a strong thrombolytic activity and weak hemolytic, and has inhibitory effect on S180 ascites tumor of mice.
Furosemide, a Blocker of Na+/K+/2Cl− Cotransporter, Diminishes Proliferation of Poorly Differentiated Human Gastric Cancer Cells by Affecting G0/G1 State (2006)

Furosemide, a blocker of Na(+)/K(+)/2Cl(-) cotransporter (NKCC), is often used as a diuretic to improve edema, ascites, and pleural effusion of patients with cancers. The aim of the present study was to investigate whether an NKCC blocker affects cancer cell growth. If so, we would clarify the mechanism of this action. We found that poorly differentiated gastric adenocarcinoma cells (MKN45) expressed the mRNA of NKCC1 three times higher than moderately differentiated ones (MKN28) and that the NKCC in MKN45 showed higher activity than that in MKN28. A cell proliferation assay indicates that furosemide significantly inhibited cell growth in MKN45 cells, but not in MKN28 cells. Using flow cytometrical analysis, we found that the exposure to furosemide brought MKN45 cells to spend more time at the G(0)/G(1) phase, but not MKN28 cells. Based on these observations, we indicate that furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity.
Effect of Molecular Weight on the Structure and Morphology of Oriented Thin Films of Regioregular Poly(3‐hexylthiophene) Grown by Directional Epitaxial Solidification (2006)

Abstract Regioregular head‐to‐tail (HT)‐coupled poly(3‐hexylthiophene‐2,5‐diyl) (P3HT) with a weight‐average molecular weight ( M w ) in the 7.3–69.6 kDa range is crystallized by directional epitaxial solidification in 1,3,5‐trichlorobenzene (TCB) to yield highly oriented thin films. An oriented and periodic lamellar structure consisting of crystalline lamellae separated by amorphous interlamellar zones is evidenced by atomic force microscopy (AFM) and transmission electron microscopy (TEM). Both the overall crystallinity as well as the orientation of the crystalline lamellae decrease significantly with increasing M w . The total lamellar periodicity is close to the length of “fully extended” chains for M w = 7.3 kDa (polystyrene‐equivalent molecular weight, eq. PS) and it saturates to a value of ca. (25–28) ± 2 nm for M w ≥ 18.8 kDa (eq. PS). This behavior is attributed to a transition from an oligomeric‐like system, for which P3HT chains are essentially in a fully extended all‐trans conformation and do not fold, to a semicrystalline system that involves a periodic alternation of crystalline lamellae separated by extended amorphous interlamellar zones, which harbor chain folds, chain ends, and tie molecules. For P3HT with M w of ca. 7.3 kDa (eq. PS), epitaxial crystallization on TCB allows for the growth of both “edge‐on” and “flat‐on” oriented crystalline lamellae on the TCB substrate. The orientation of the lamellae is attributed to 1D epitaxy. Because of the large size of the “flat‐on” crystalline lamellae, a characteristic single‐crystal electron diffraction pattern corresponding to the [001] zone was obtained by selected area electron diffraction (SAED), indicating that P3HT crystallizes in a monoclinic unit cell with a = 16.0 Å, b = 7.8 Å, c = 7.8 Å, and γ = 93.5°.
Pulmonary Vascular Disease in Bronchopulmonary Dysplasia (2016)

Pulmonary vascular disease and pulmonary hypertension (PH) contributes significantly to the pathogenesis, pathophysiology, and clinical course of infants with bronchopulmonary dysplasia (BPD). This article briefly reviews the impact of premature birth on the developing lung circulation, mechanisms that contribute to the development of PH in premature newborns, and the diagnostic evaluation and management of severe PH in infants with BPD.
Adaptive Skip Intervals: Temporal Abstraction for Recurrent Dynamical Models (2018)

We introduce a method which enables a recurrent dynamics model to be temporally abstract. Our approach, which we call Adaptive Skip Intervals (ASI), is based on the observation that in many sequential prediction tasks, the exact time at which events occur is irrelevant to the underlying objective. Moreover, in many situations, there exist prediction intervals which result in particularly easy-to-predict transitions. We show that there are prediction tasks for which we gain both computational efficiency and prediction accuracy by allowing the model to make predictions at a sampling rate which it can choose itself.
Therapeutic potential of anti-CD137 (4-1BB) monoclonal antibodies (2015)

Research so far indicates that 4-1BB is highly protective against various pathological conditions including cancer. However, a few important side effects of 4-1BB therapy such as liver toxicity, thrombocytopenia, anemia, and suppressive effects on certain immune competent cells should be taken into consideration before it is used for human therapy.
Immunosuppressant deoxyspergualin induces apoptotic cell death in dividing cells (1998)

Deoxyspergualin (DSG) has been found to have an antitumour and immunosuppressive activity. However, the precise mechanism of action of DSG has not been clarified. We have used its analogue, methyldeoxyspergualin (MeDSG) for in vitro culture studies of DSG since it shows good stability in aqueous solution and retains strong immunosuppressive activity. In the present study, we found that MeDSG inhibited proliferation of rapidly dividing murine T-cell hybridomas, resulting in cell death. The cell death was accompanied by chromatin condensation and DNA cleavage at the linker regions between nucleosomes. Furthermore, MeDSG induced a reduction in mitochondrial transmembrane potential. When murine thymocytes were treated with MeDSG for 48 hr, a slight increase of DNA fragmentation was constantly observed, and selective depletion of CD4- CD8- cells was noticed. In contrast, CD4+ CD8+ cells were hardly affected. Moreover, splenic T-cells are resistant to MeDSG-induced apoptosis, as evaluated by measuring DNA cleavage. Our findings may account for the immunosuppressive and antitumour properties of DSG which were described in a number of previous studies.
Ontogeny, Intraspecific Variation, and Systematics of the Late Cambrian Trilobite Dikelocephalus (1994)

Biometric analyses of well-localized specimens of the trilobite Dikelocephalus from the St. Lawrence Formation (Upper Cambrian), northern Mississippi Valley, suggest that all specimens belong to a single, highly variable morphospecies, D. minnesotensis.A complex pattern of ontogenetically-related and ontogeny-independent variation produced a mosaic of morphotypes, which show greater diversity than previously recorded within trilobite species.There is considerable variation within collections made from single beds.Variations of characters among collections are mosaic, and are clinal in some cases.Patterns of variation within Dikelocephalus cannot be related to lithofacies occurrence.There are no obvious temporal variations in D. minnesotensis within the St. Lawrence Formation, but some Dikelocephalus from the underlying Ttinnel City Group may belong to a different taxon.The validity of this early taxon is questionable due to a lack of available material.The mosaic pattern of variation in Dikelocephalus mimics that documented at higher taxonomic levels in primitive libristomate trilobites, and helps explain difficulties in providing a workable taxonomy of primitive trilobites.Results caution proposition of evolutionary scenarios that do not take account of intraspecific variation.The recovery of dorsal shields of Dikelocephalus permits the first detailed reconstruction of the entire exoskeleton.The systematics of the genus is revised and twenty-five species are suppressed as junior synonyms of D. minnesotensis.
GC/MS-based urine metabolomics analysis of renal allograft recipients with acute rejection (2018)

Urine metabolites identified with GC/MS can effectively distinguish acute rejection from stable transplant recipients, supporting the potential utility of metabolome analysis in non-invasive diagnosis of acute rejection.
Decomposing image computation for symbolic reachability analysis using control flow information (2006)

The main challenge in BDD-based symbolic reachability analysis is represented by the sizes of the intermediate decision diagrams obtained during image computations. Methods proposed to mitigate this problem fall broadly into two categories: Search strategies that depart from breadth-first search, and efficient techniques for image computation. In this paper we present an algorithm that belongs to the latter category. It exploits define-use information along executable paths extracted from the control-flow graph of the model being analyzed; this information enables an effective constraining of the transition relation and a decomposition of the image computation process that often leads to much smaller intermediate BDDs. Our experiments confirm that this reduction in the size of the representation of state sets translates in significant decreases in CPU and memory requirements.
La population de la France à l'horizon 2000 (1978)

Dinh Quang Chi, Labat Jean-Claude. La population de la France à l'horizon 2000. In: Economie et statistique, n°101, Juin 1978. La population française en l'an 2000 / L'emploi en régions / Les vacances / Un modèle d'analyse à court terme: METRIC. pp. 3-10.
Low aspect ratio micropores for single‐particle and single‐cell analysis (2015)

This paper describes microparticle and bacterial translocation studies using low aspect ratio solid-state micropores. Micropores, 5 μm in diameter, were fabricated in 200 nm thick free-standing silicon nitride membranes, resulting in pores with an extremely low aspect ratio, nominally 0.04. For microparticle translocation experiments, sulfonated polystyrene microparticles and magnetic microbeads in size range of 1-4 μm were used. Using the microparticle translocation characteristics, we find that particle translocations result in a change only in the pore's geometrical resistance while the access resistance remains constant. Furthermore, we demonstrate the ability of our micropore to probe high-resolution shape information of translocating analytes using concatenated magnetic microspheres. Distinct current drop peaks were observed for each microsphere of the multibead architecture. For bacterial translocation experiments, nonflagellated Escherichia coli (strain HCB 5) and wild type flagellated Salmonella typhimurium (strain SJW1103) were used. Distinct current signatures for the two bacteria were obtained and this difference in translocation behavior was attributed to different surface protein distributions on the bacteria. Our findings may help in developing low aspect ratio pores for high-resolution microparticle characterization and single-cell analysis.
Cheap Orthogonal Constraints in Neural Networks: A Simple Parametrization of the Orthogonal and Unitary Group (2019)

We introduce a novel approach to perform first-order optimization with orthogonal and unitary constraints. This approach is based on a parametrization stemming from Lie group theory through the exponential map. The parametrization transforms the constrained optimization problem into an unconstrained one over a Euclidean space, for which common first-order optimization methods can be used. The theoretical results presented are general enough to cover the special orthogonal group, the unitary group and, in general, any connected compact Lie group. We discuss how this and other parametrizations can be computed efficiently through an implementation trick, making numerically complex parametrizations usable at a negligible runtime cost in neural networks. In particular, we apply our results to RNNs with orthogonal recurrent weights, yielding a new architecture called expRNN. We demonstrate how our method constitutes a more robust approach to optimization with orthogonal constraints, showing faster, accurate, and more stable convergence in several tasks designed to test RNNs.
Development and production of 18Mn-18Cr non-magnetic retaining ring with high yield strength. (1990)

Retaining ring for e]ectric generator is required to have non-magnetism, high strength, high ductility and stress corrosion cracking (SCC)resistance.
Amino acid sequence of porcine parathyroid hormone (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleAmino acid sequence of porcine parathyroid hormoneRobert T. Sauer, Hugh D. Niall, Mary L. Hogan, Henry T. Keutmann, Jeffrey L. H. O'Riordan, and John T. Potts, Jr.Cite this: Biochemistry 1974, 13, 9, 1994–1999Publication Date (Print):April 1, 1974Publication History Published online1 May 2002Published inissue 1 April 1974https://pubs.acs.org/doi/10.1021/bi00706a033https://doi.org/10.1021/bi00706a033research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antidepressant treatments in the 21st century (1998)

The goal of this review is to provide a provocative discussion of the status of antidepressant treatments in the next century. The first a part of the review evaluates the progress (or lack of progress) made in antidepressant medications since the 1950s, when the first chemical antidepressants were discovered by serendipity. The second part then attempts to predict what may be needed to accomplish greater progress in the future, and outlines the types of approaches that could be used to develop truly novel, and more effective, treatments of depression.
Mutual exclusivity loss for semi-supervised deep learning (2016)

In this paper we consider the problem of semi-supervised learning with deep Convolutional Neural Networks (ConvNets). Semi-supervised learning is motivated on the observation that unlabeled data is cheap and can be used to improve the accuracy of classifiers. In this paper we propose an unsupervised regularization term that explicitly forces the classifier's prediction for multiple classes to be mutually-exclusive and effectively guides the decision boundary to lie on the low density space between the manifolds corresponding to different classes of data. Our proposed approach is general and can be used with any backpropagation-based learning method. We show through different experiments that our method can improve the object recognition performance of ConvNets using unlabeled data.
The Value Of Antihypertensive Drugs: A Perspective On Medical Innovation (2007)

Using national survey data and risk equations from the Framingham Heart Study, we quantify the impact of antihypertensive therapy changes on blood pressures and the number and cost of heart attacks, strokes, and deaths. Antihypertensive therapy has had a major impact on health. Without it, 1999-2000 average blood pressures (at age 40+) would have been 10-13 percent higher, and 86,000 excess premature deaths from cardiovascular disease would have occurred in 2001. Treatment has generated a benefit-to-cost ratio of at least 6:1, but much more can be achieved. More effective use of antihypertensive medication would have an impact on mortality akin to eliminating all deaths from medical errors or accidents.
Heterogeneity of lipid A: comparison of lipid A types from different gram-negative bacteria (1984)

Chloroform-soluble purified lipid A preparations from 10 sources, including five Escherichia coli strains (EH100, K-12, O127, O111, RCDC), two Salmonella strains (Salmonella typhimurium, Salmonella minnesota R595), Shigella sonnei II, and a hybrid of Shigella flexneri and E. coli K-12, were compared with lipid A from S. flexneri. Purified lipid A from S. flexneri was earlier found to be composed of eight fractions. The various lipid A preparations were assayed by thin-layer chromatography. Chromatograms were stained for phosphate or carbohydrate by molybdenum blue or orcinol, respectively. The number of major bands found for each lipid A preparation varied between 7 and 10, depending on the source. Comparable bands, based on Rf, were found among all of the different lipid A preparations, but the quantity of each band varied between the sources of lipid A. Four bands (designated 2, 3, 7, and 8) were abundant in every preparation. Variations of conditions used for preparing lipid A, such as changing of hydrolysis time, did not affect the appearance of lipid A on thin-layer chromatography. Change in the type of acid used for hydrolysis also did not affect the band pattern, but it did change the quantitative amounts of the various bands to some degree.
Operating system support for object dependencies in persistent object stores (2002)

Persistent object stores provide uniform management of short-term and long-term objects. Such stores ensure the integrity of the data even after occurrence of a failure, by guaranteeing the existence of some previous self-consistent stable state at each point in time. Maintaining a consistent state of a persistent store necessitates recording of inter-object dependencies and checkpointing of each object together with all its dependent objects. Directed graphs may be used to describe such dependencies. We describe eager and lazy construction of dependency graphs. We then address operating system and hardware support for management of dependencies.
<title>Filter windows for EUV lithography</title> (2001)

Extreme-ultraviolet (EUV) lithography based on reflective optics is expected to require at least one filter window to 1) reduce out-of-band radiation in the ultraviolet, visible and infrared, 2) partially protect the optics from debris from the radiation source and any outgassing from the resist on the wafer, and 3) perhaps to serve as a barrier for EUV absorbing gasses. To maximize wafer throughput, the filter window or windows will need to provide the highest possible transmittance at 13.4 nm. EUV filters must operate in a harsh vacuum environment. They will be irradiated with high energy EUV light and will absorb out-of-band radiation that will cause temperature increases of greater than 100 degree(s)C. Outgassing from the filters must be minimal, and they must survive handling as well as pressure differentials during pump-down operation, and return-to-atmospheric pressure. Prototype filters were fabricated for Sandia's Engineering Test Stand (ETS) and are being utilized in on-going EUV lithography demonstrations. Their in and out-of-band transmittance has been measured and found to meet Sandia's performance specifications, and they have been exposed to various environments with good results.
A Wandering Mind Is an Unhappy Mind (2010)

We developed a smartphone technology to sample people's ongoing thoughts, feelings, and actions and found (i) that people are thinking about what is not happening almost as often as they are thinking about what is and (ii) found that doing so typically makes them unhappy.
Effect of Lactobacillus rhamnosus KY-3 and Cellobiose as Synbiotics on Lipid Metabolism in Rats (2004)

Lactobacillus rhamnosus KY-3 is a fermentative bacterium that is used for the industrial production of L-lactic acid. We have examined the effect of L. rhamnosus KY-3 and cellobiose as synbiotics on lipid metabolism in rats. Rats were fed on a 20% casein diet (C) supplemented with either 1.7% L. rhamnosus KY-3 (KY-3), 10% cellobiose (CEB), or 1.7% L. rhamnosus KY-3 and 10% cellobiose (KY-3+CEB) for 13 d. The concentrations of serum total lipids, triacylglycerol, total cholesterol, and phospholipids were significantly reduced in rats fed a KY-3+CEB diet in comparison to those on the C, KY-3 and CEB diets. There was an increase in the weight of cecal contents and a significant increase in the amount of cecal short-chain fatty acids (SCFA). The dry weight of excretion increased additively upon the simultaneous administration of L. rhamnosus KY-3 and cellobiose (KY-3 + CEB). The amount of excreted fecal bile acids did not differ among the groups in this study. These findings support the hypothesis that the promotion of cecal fermentation can lower the level of serum lipids. These results suggest that simultaneous administration of L. rhamnosus KY-3 and cellobiose as synbiotics has a beneficial effect on lipid metabolism.