gebhart/patrepeval huggingface dataset:
Simulation-based test algorithm generation and port scheduling for multi-port memories (2001)

The paper presents a simulation-based test algorithm generation and test scheduling methodology for multi-port memories. The purpose is to minimize the testing time while keeping the test algorithm in a simple and regular format for easy test generation, fault diagnosis, and built-in self-test (BIST) circuit implementation. Conventional functional fault models are used to generate tests covering most defects. In addition, multi-port specific defects are covered using structural fault models. Port-scheduling is introduced to take advantage of the inherent parallelism among different ports. Experimental results for commonly used multi-port memories, including dual-port, four-port, and $n$-read-1-write memories, have been obtained, showing that efficient test algorithms can be generated and scheduled to meet different test bandwidth constraints. Moreover, memories with more ports benefit more with respect to testing time.
Molecular cloning and characterization of the fusaric acid-resistance gene from Pseudomonas cepacia. (1991)

Fusaric acid-resistance genes (fus) were isolated from Pseudomonas cepacia. The nucleotides of the 5437 base pairs containing the fus genes were sequenced.
Alloy Electrocatalysts (2006)

Improving efficiency and reducing overall cost are two key issues to the commercialization of fuel cell powered vehicles. Electrocatalysts play an important role, particularly in the cathode, where the oxygen reduction reaction is sluggish and the noble metal loading is relatively high. To discover less expensive and more active cathode catalysts, a novel combinatorial workflow has been developed to investigate alloy-based electrocatalysts. In addition to the discovery program, various synthesis technologies have been studied and developed to engineer nanoscale catalyst particles with controllable size, monodispersity, and microcomposition. The progress of these research activities is reported with particular attention focused on the activity–stability–composition relationship for a series of platinum-based metal alloys.
Novel antitenascin antibody with increased tumour localisation for Pretargeted Antibody-Guided RadioImmunoTherapy (PAGRIT) (2003)

The Pretargeted Antibody-Guided RadioImmunoTherapy (PAGRIT) method is based on intravenous, sequential administration of a biotinylated antibody, avidin/streptavidin and (90)Y-labelled biotin. The hybridoma clone producing the monoclonal antitenascin antibody BC4, previously used for clinical applications, was found not suitable for further development because of the production of an additional, nonfunctional light chain. In order to solve this problem, the new cST2146 hybridoma clone was generated. The monoclonal antibody ST2146, produced by this hybridoma, having the same specificity as BC4 but lacking the nonfunctional light chain, was characterised. ST2146 was found able to bind human tenascin at an epitope strictly related, if not identical, to the antigenic epitope of BC4. It showed, compared to BC4, higher affinity and immunoreactivity and similar selectivity by immunohistochemistry. Biodistribution studies of biotinylated ST2146 and three other monoclonal antitenascin antibodies showed for ST2146 the highest and more specific tumour localisation in HT29-grafted nude mice. On the overall, ST2146 appears to be a good alternative to BC4 for further clinical development of PAGRIT.
Anticaries efficacy of a new dentifrice for hypersensitivity. (2003)

Each of these studies indicated the new dentifrice for hypersensitivity (Colgate Sensitive Maximum Strength) was effective in inhibiting the caries process. The data demonstrate that this new dentifrice is predicted to be highly effective against caries and equivalent to a positive control dentifrice.
Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in <i>Mycobacterium tuberculosis</i> (2016)

A two-drug combination therapy where one drug targets an offending cell and the other targets a resistance mechanism to the first drug is a time-tested, yet underexploited approach to combat or prevent drug resistance. By high-throughput screening, we identified a sulfonamide scaffold that served as a pharmacophore to generate inhibitors of Mycobacterium tuberculosis acetyltransferase Eis, whose upregulation causes resistance to the aminoglycoside (AG) antibiotic kanamycin A (KAN) in Mycobacterium tuberculosis. Rational systematic derivatization of this scaffold to maximize Eis inhibition and abolish the Eis-mediated KAN resistance of M. tuberculosis yielded several highly potent agents. A crystal structure of Eis in complex with one of the most potent inhibitors revealed that the inhibitor bound Eis in the AG-binding pocket held by a conformationally malleable region of Eis (residues 28-37) bearing key hydrophobic residues. These Eis inhibitors are promising leads for preclinical development of innovative AG combination therapies against resistant TB.
Planar 1T-cell DRAM with MOS storage capacitors in a 130nm logic technology for high density microprocessors caches (2002)

IT-cell DRAM arrays with planar MOS capacitors are fabricated in a high performance 130nm logic technology without any process enhancements. Storage capacitors are operated in traditional inversion mode (N+/P), accumulation mode (P+/N) and in depletion mode (P+/P). The P+/P storage cap cell is 3.5X smaller than a 6T SRAM cell and gives a 2X array density advantage over the best SRAM cache design. Measured retention time at 110°C is 350ns with 1W/cm2 refresh power density.
<title>Multiresolution transform and its application to pattern recognition</title> (1996)

Traditional wavelet edge detection and encoding schemes preserve shape features of objects effectively at a variety of spatial scales and also allow an efficient means of image and video compression. However these schemes also remove texture from imagery and thus image reproduction quality suffers. Fractal encoding techniques on the other hand generate high compression ratios but tend to introduce blocky artifacts in imagery. Thus we describe an encoding method that combines the shape preserving capability of wavelets with the compression qualities of fractal compression for a hybrid multiresolution technique that achieves high compression, selective and accurate feature preservation, and is computationally efficient.
U.sup.+4 generation in HTER (2006)

A improved device and process for recycling spent nuclear fuels, in particular uranium metal, that facilitates the refinement and recovery of uranium metal from spent metallic nuclear fuels. The electrorefiner device comprises two anodes in predetermined spatial relation to a cathode. The anodese have separate current and voltage controls. A much higher voltage than normal for the electrorefining process is applied to the second anode, thereby facilitating oxidization of uranium (III), U.sup.+, to uranium (IV), U.sup.+4. The current path from the second anode to the cathode is physically shorter than the similar current path from the second anode to the spent nuclear fuel contained in a first anode shaped as a basket. The resulting U.sup.+4 oxidizes and solubilizes rough uranium deposited on the surface of the cathode. A softer uranium metal surface is left on the cathode and is more readily removed by a scraper.
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models (2019)

Although botulinum neurotoxin serotype A (BoNT/A) products are common treatments for various disorders, there is only one commercial BoNT/B product, whose low potency, likely stemming from low affinity toward its human receptor synaptotagmin 2 (hSyt2), has limited its therapeutic usefulness. We express and characterize two full-length recombinant BoNT/B1 proteins containing designed mutations E1191M/S1199Y (rBoNT/B1<sub>MY</sub>) and E1191Q/S1199W (rBoNT/B1<sub>QW</sub>) that enhance binding to hSyt2. In preclinical models including human-induced pluripotent stem cell neurons and a humanized transgenic mouse, this increased hSyt2 affinity results in high potency, comparable to that of BoNT/A. Last, we solve the cocrystal structure of rBoNT/B1<sub>MY</sub> in complex with peptides of hSyt2 and its homolog hSyt1. We demonstrate that neuronal surface receptor binding limits the clinical efficacy of unmodified BoNT/B and that modified BoNT/B proteins have promising clinical potential.
Generation of 36-femtosecond pulses from a ytterbium fiber laser (2004)

By optimizing the cavity dispersion map, 1.5-nJ, 36-fs pulses are obtained from a Yb-doped fiber laser. Higher-order dispersion currently limits the pulse duration.
Antidepressant efficacy screening of novel targets in the chick anxiety-depression model (2009)

The chick anxiety-depression model is a hybrid simulation, which may prove useful as an early preclinical dual pharmacological screen for novel therapeutics. Separate dose-response studies were conducted with seven test compounds that have screened positive for antidepressant effects in rodent depression models and included prasterone (5.0-40.0 mg/kg), memantine (2.5-20.0 mg/kg), ketamine (1.0-10.0 mg/kg), mifepristone (50.0-400.0 mg/kg), DOV216,303 (5.0-20.0 mg/kg), CGP36742 (2.5-15.0 mg/kg), and antalarmin (1.0-30.0 mg/kg). Chicks aged 4-6 days posthatch received test compounds intramuscularly 15 min before social separation, in which distress vocalization rates were recorded. High rates of vocalization in the first phase (0-5 min) of social separation seem to model an anxiety-like state and lower rates of vocalization in the second phase (30-60 min) seem to model a depression-like state. Prasterone, memantine, ketamine, and DOV216,303 attenuated and CPG36742 enhanced the pattern of vocalizations in the first phase. Prasterone, ketamine, mifepristone, DOV216,303, and CPG36742 attenuated and memantine and antalarmin enhanced the pattern of vocalizations in the second phase. This pattern of drug effects parallels what clinical data exist, and highlights two important characteristics of this dual-screening assay. For the compounds tested, this chick model identified phase II and III clinical failures (e.g. memantine and antalarmin) and has the potential to reveal possible contraindications of compounds (i.e. CPG36742) in cases where anxiety symptoms are concomitant with a depressive episode.
Ghrelin octanoylation by ghrelin <i>O</i>-acyltransferase: Unique protein biochemistry underlying metabolic signaling (2019)

Ghrelin is a small peptide hormone that requires a unique post-translational modification, serine octanoylation, to bind and activate the GHS-R1a receptor. Ghrelin signaling is implicated in a variety of neurological and physiological processes, but is most well known for its roles in controlling hunger and metabolic regulation. Ghrelin octanoylation is catalyzed by ghrelin <i>O</i>-acyltransferase (GOAT), a member of the membrane-bound <i>O</i>-acyltransferase (MBOAT) enzyme family. From the status of ghrelin as the only substrate for GOAT in the human genome to the source and requirement for the octanoyl acyl donor, the ghrelin-GOAT system is defined by multiple unique aspects within both protein biochemistry and endocrinology. In this review, we examine recent advances in our understanding of the interactions and mechanisms leading to ghrelin modification by GOAT, discuss the potential sources for the octanoyl acyl donor required for ghrelin's activation, and summarize the current landscape of molecules targeting ghrelin octanoylation through GOAT inhibition.
Colour matching comparison between spectrophotometric and multispectral imaging measurements (2016)

This paper compares colour matching of yarn‐dyed fabrics by spectrophotometric and multispectral imaging techniques. While it is well known that multispectral imaging systems can measure the colour of fabrics that cannot be acquired by spectrophotometers, comparison of these two types of instrument has not yet been well explored. Colour measurements of 44 pairs of standard and batch solid‐colour yarn‐dyed fabrics by means of a Datacolor 650 spectrophotometer and an imaging colour measurement ( ICM ) multispectral imaging system were compared. Experimental results show that the ICM system has the capability to measure similar hue a * differences and larger lightness L * and hue b * differences than the Datacolor 650 spectrophotometer. When the tolerance of colour matching is set to 1.0 CMC (2:1) (colour difference) unit, the ICM system can achieve the same colour matching results as the Datacolor 650 spectrophotometer, except for two dark samples.
Design and performance of single-mode plug-in type optical-fiber connectors (1990)

A new system of compact single-mode plug-in-type optical-fiber connectors is developed for multiple optical connections between a printed board and a back panel. This new system consists of two types of plug-in connectors: one has two optical plugs/jacks with 64 electrical terminals, and the other has four optical plugs/jacks without electrical terminals. This system utilizes a novel alignment mechanism for plugs and jacks and a novel fiber-core adjustment technology. The performance of assembled plug-in optical-fiber connectors was measured and confirmed to have the following characteristics: insertion losses are less than 0.4 dB and return losses are larger than 28 dB; mechanical tests such as mating, vibration, and shock, and environment tests such as temperature cycling, thermal aging, and high humidity with temperature cycling reveal extremely stable characteristics; and transmission tests using 1.8-Gb/s pseudorandom pulse patterns show low error rates of less than 10/sup -11/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automation of feature engineering for IoT analytics (2018)

This paper presents an approach for automation of interpretable feature selection for Internet Of Things Analytics (IoTA) using machine learning (ML) techniques. Authors have conducted a survey over different people involved in different IoTA based application development tasks. The survey reveals that feature selection is the most time consuming and niche skill demanding part of the entire workflow. This paper shows how feature selection is successfully automated without sacrificing the decision making accuracy and thereby reducing the project completion time and cost of hiring expensive resources. Several pattern recognition principles and state of art (SoA) ML techniques are followed to design the overall approach for the proposed automation. Three data sets are considered to establish the proof-of-concept. Experimental results show that the proposed automation is able to reduce the time for feature selection to 2 days instead of 4 -- 6 months which would have been required in absence of the automation. This reduction in time is achieved without any sacrifice in the accuracy of the decision making process. Proposed method is also compared against Multi Layer Perceptron (MLP) model as most of the state of the art works on IoTA uses MLP based Deep Learning. Moreover the feature selection method is compared against SoA feature reduction technique namely Principal Component Analysis (PCA) and its variants. The results obtained show that the proposed method is effective.
Temporal Quality Evaluation for Enhancing Compressed Video (2007)

This paper proposes a metric to quantify the effect of the video frame loss according to their impact toward perceived temporal quality. This metric utilizes information obtained from pixel domain and particularly aims at measuring the temporal video quality degradation caused by both regular and irregular frame loss. As one application, the proposed temporal quality metric is used to evaluate the benefit of adaptive thresholding in frame skipping algorithms at the encoder. Temporal quality metric shows high prediction accuracy compared to subjective quality evaluation. Furthermore, it is shown by the experimental results that proposed temporal quality metric precisely differentiates between different frame skipping approaches and can be effectively used to evaluate them. With the help of the proposed quality metric, encoders can be designed to drop frames effectively with minimal perceptual video quality degradation.
Switched Reluctance Machines with higher rotor poles than stator poles for improved output torque characteristics (2009)

Switched reluctance motor (SRM) drives have gained considerable popularity for automotive, defense and aerospace applications which desire ruggedness, high speed capability, and fault tolerance. In spite of significant progress in the development of advanced control strategies over the past two decades, high levels of torque pulsation and acoustic noise in SRM drives still present a major shortcoming. This paper discusses the improvement of torque characteristics of an SRM by including a higher number of rotor poles than stator poles. A numerical relationship called pole design (PD) formula is used to generate new configurations of SRMs. Particularly, this paper focuses on the enhancement of design and development of a SRM, whether operated as a motor, generator, or both, based on this novel formula and investigates such design for low cost manufacturing for high volume applications, torque ripple, torque density, and efficiency. For the verification of the claims presented, a prototype SRM designed using PD formula with 6 stator poles and 10 rotor poles (6/10 configuration) is evaluated and compared to a conventional three-phase 6/4 configuration with similar constraints. Results obtained from simulations using finite element analysis (FEA) and experimental measurements have been presented comparing the output torque for each topology. Comparisons have been made in terms of torque ripple and average torque values for two specific conduction angles.
基于稀疏贝耶斯的多光谱自发荧光断层成像重建方法 (2010)

We present a sparse Bayesian reconstruction method based on multiple types of a priori information for multispectral bioluminescence tomography (BLT). In the Bayesian approach, five kinds of a priori information are incorporated, reducing the ill-posedness of BLT. Specifically, source sparsity characteristic is considered to promote reconstruction results. Considering the computational burden in the multispectral case, a series of strategies is adopted to improve computational efficiency, such as optimal permissible source region strategy and node model of the finite element method. The performance of the proposed algorithm is validated by a heterogeneous three-dimensional (3D) micron scale computed tomography atlas and a mouse-shaped phantom. Reconstructed results demonstrate the feasibility and effectiveness of the proposed algorithm.
Nociceptin/Orphanin FQ(1—13)NH<sub>2</sub> Analogues Modified in the Phe<sup>1</sup>‐Gly<sup>2</sup> Peptide Bond (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: SYNTHESES OF 4′‐DEOXYKANAMYCIN AND 4′‐DEOXYKANAMYCIN B (1977)

Abstract Aus Kanamycin (I) wird durch N‐Benzyloxycarbonylierung, 4",6"‐O‐Cyclohexylidenierung, selektive Benzoylierung der 2′‐, 3′‐ und 2"‐OH‐Gruppen, 4′‐O‐Mesylierung, 4′‐Jodierung, 4′‐Hydrierung und anschließende Abspaltung der Benzoyl‐, Cyclohexyliden‐ und Benzyloxycarbonyl‐Schutzgruppen 4′‐Desoxykanamycin (II) dargestellt.
Magnetostriction and magnetization of iron-based amorphous alloys (1980)

The magnetostriction constant and saturation magnetization at room temperature are measured for iron-based amorphous alloys containing various kinds of metalloid and metal atoms, except Co and Ni. The data show that the magnetostriction constant is proportional to the square of the saturation magnetization for these alloys.
COFTA: hardware-software co-synthesis of heterogeneous distributed embedded system architectures for low overhead fault tolerance (2002)

Hardware-software co-synthesis is the process of partitioning an embedded system specification into hardware and software modules to meet performance, cost and reliability goals. In this paper, we address the problem of hardware-software co-synthesis of fault-tolerant real-time heterogeneous distributed embedded systems. Fault detection capability is imparted to the embedded system by adding assertion and duplicate-and-compare tasks to the task graph specification prior to cosynthesis. The reliability and availability of the architecture are evaluated during co-synthesis. Our algorithm allows the user to specify multiple types of assertions for each task. It uses the assertion or combination of assertions which achieves the required fault coverage without incurring too much overhead. We propose new methods to: 1) perform fault tolerance based task clustering 2) derive the best error recovery topology using a small number of extra processing elements, 3) exploit multi-dimensional assertions, and 4) share assertions to reduce the fault tolerance overhead. Our algorithm can tackle multirate systems commonly found in multimedia applications. Application of the proposed algorithm to several real-life telecom transport system examples shows its efficacy.
Secured Utility Bill Data Storage via Wavefront-Multiplexing (2013)

Securedand reliable data storage and transport, such as private information in utility bills, are among many important concerns on smart grid. Instead of utilizing separated encryption and redundancy techniques, we choose wavefront multiplexing/demultiplexing process (WF muxing/demuxing) utilizing multi-dimensional transmissions to perform both security and reliability for data storage and transport. Multiple data sets are preprocessed by a WF muxing transformation, in which multiple data sets have been "orthogonally processed" and disassembled into any scalable number of sets of processed data, with each set being stored on a storage site or transported to destinations. The original data is reassembled via a WF demuxing transformation after retrieving a lesser but scalable number of WF muxed data sets.
Carrier transport in nBn infrared detectors (2016)

The nBn photodetector architecture proposed and demonstrated by Maimon and Wicks provides an effective means for lowering generation-recombination dark current by suppressing Shockley-Read-Hall processes, and for reducing surface leakage dark current. This has been especially beneficial for III-V semiconductor based infrared photodiodes, which traditionally tend to suffer from excess depletion dark current and lack of good surface passivation. We examine how contact (n), barrier (B), and absorber (n) properties can affect carrier transport in nBn infrared detector. In an nBn detector the unipolar electron barrier should block only the electrons while allowing the un-impeded flow of holes, but improper barrier doping or barrier-absorber band offset could also block hole transport and result in higher turn-on bias. Contact doping has also been observed to result in higher turn-on bias at higher temperatures. In the case when the absorber is made from n-doped type-II superlattice (T2SL), although it is often assumed that the exceedingly large growth-direction band-edge curvature hole effective mass in n-type long-wavelength infrared (LWIR) T2SL would lead to low hole mobility and therefore low detector collection quantum efficiency, in practice mid-wavelength infrared (MWIR) and LWIR nBn infrared detectors have demonstrated good optical response. We explore how hole mobility can be affected by band structure effects such as band mixing and subband splitting to gain better understanding of hole transport in T2SL.