gebhart/patrepeval huggingface dataset:
Middleware-level QoS differentiation in the wireless Internet: the ubiQoS solution for audio streaming over Bluetooth (2004)

The ultimate goal of mobile and ubiquitous Internet accessibility is not only the seamless integration of wireless devices with traditional fixed networks but also the dynamic differentiation of quality of service (QoS) levels depending on client characteristics. In this context, the paper presents the provisioning of audio streaming with different QoS levels in the application-level ubiQoS middleware. In particular, it focuses on how ubiQoS manages the QoS over the last segment of the audio distribution path towards Bluetooth clients by allocating different types of Bluetooth communication channels (unicast connection-oriented or broadcast connectionless) depending on the differentiated QoS requirements of different user classes. To this purpose, we have developed a library that extends the JSR82 standard with the support of active slave broadcast, thus simplifying the Java-based management of Bluetooth communications. The reported experimental results show the feasibility of our application-level middleware approach in the challenging case of audio streaming with differentiated QoS to resource-limited Bluetooth devices.
Rosiglitazone RECORD study: glucose control outcomes at 18 months (2007)

In people with diabetes, rosiglitazone in combination with metformin or sulphonylurea was demonstrated to be non-inferior to the standard combination of metformin + sulphonylurea in lowering HbA(1c) over 18 months, and produces greater improvements in C-reactive protein and basal insulin sensitivity but is also associated with greater weight gain.
Cloud Radio Access Network architecture. Towards 5G mobile networks (2016)

Cloud Radio Access Network (C-RAN) is a novel mobile network architecture which can address a number of challenges that mobile operators face while trying to support ever-growing end-users’ needs towards 5th generation of mobile networks (5G). The main idea behind C-RAN is to split the base stations into radio and baseband parts, and pool the Baseband Units (BBUs) from multiple base stations into a centralized and virtualized BBU Pool. This gives a number of benefits in terms of cost and capacity. However, the challenge is then to find an optimal functionality splitting point as well as to design the socalled fronthaul network, interconnecting those parts. This thesis focuses on quantifying those benefits and proposing a flexible and capacity-optimized fronthaul network. It is shown that a C-RAN with a functional split resulting in a variable bit rate on the fronthaul links brings cost savings due to the multiplexing gains in the BBU pool and the fronthaul network. The cost of a fronthaul network deployment and operation can be further reduced by sharing infrastructure between fronthaul and other services. The origins of multiplexing gains in terms of traffic burstiness, the tidal effect and various possible functional splits are analyzed and quantified. Sharing baseband resources between many cells is possible for traditional C-RANs. However, in order to further benefit from multiplexing gains on fronthaul, it is recommended to implement a functional split yielding variable bit rate in the fronthaul. For the analyzed data sets, in deployments where diverse traffic types are mixed (bursty, e.g., web browsing and constant bit rate, e.g., video streaming) and cells from various geographical areas (e.g., office and residential) are connected to the BBU pool, the multiplexing gain value reaches six. Using packet-based fronthaul has the potential to utilize fronthaul resources efficiently. However, meeting synchronization and delay requirements is a challenge. As a possible solution, the use of IEEE Precision Time Protocol (PTP) (also known as 1588v2) has been evaluated, and for the analyzed scenario it can assure synchronization on the nanosecond level, fulfilling mobile network requirements. Furthermore, mechanisms to lower delay and jitter have been identified, namely: source scheduling and preemption. An innovative source scheduling scheme which can minimize jitter has been proposed. The scheme is optimized for symmetric downlink and uplink traffic, but can also be used when downlink traffic exceeds uplink. Moreover, a demonstrator of a Software Defined Networking (SDN) controlled Ethernet fronthaul has been built.
Markov random field models for unsupervised segmentation of textured color images (1995)

We present an unsupervised segmentation algorithm which uses Markov random field models for color textures. These models characterize a texture in terms of spatial interaction within each color plane and interaction between different color planes. The models are used by a segmentation algorithm based on agglomerative hierarchical clustering. At the heart of agglomerative clustering is a stepwise optimal merging process that at each iteration maximizes a global performance functional based on the conditional pseudolikelihood of the image. A test for stopping the clustering is applied based on rapid changes in the pseudolikelihood. We provide experimental results that illustrate the advantages of using color texture models and that demonstrate the performance of the segmentation algorithm on color images of natural scenes. Most of the processing during segmentation is local making the algorithm amenable to high performance parallel implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Zero HAPUs (2012)

Toni C. Clark is a manager at the Iowa Methodist Medical Center in Des Moines, Iowa. The author has disclosed that she has no financial relationships related to this article.
Evidence for Differential Binding of Growth Hormones to Membrane and Cytosolic GH Binding Proteins of Rabbit Liver (1986)

The existence of three GH binding proteins in rabbit liver membranes has been adduced from binding studies with a panel of monoclonal antibodies. Immunologically cross-reactive analogues of 'type 2' binding proteins were shown to exist in rabbit liver cytosol and in affinity purified receptor from liver microsomes. We now report differences in the binding of human and ovine GH with respect to two antigenic determinants on the 'type 1' GH binding protein. The discovery of these differences has enabled the detection of cross-reactive analogues of both binding protein types '1' and '2' in liver cytosol and in affinity purified preparations from liver membranes. These findings show a close structural relationship between the pool of cytosolic GH binding proteins and those present in the membranes; and differential ligand binding to, as well as absolute ligand selection by GH binding proteins, which could reflect the ability of GH to trigger a range of biological responses either through different receptors or differential interaction with particular receptor subtypes.
Thermoresponsive Carbohydrate-<i>b</i>-Polypeptoid Polymer Vesicles with Selective Solute Permeability and Permeable Factors for Solutes (2021)

Solute-permeable polymer vesicles are structural compartments for nanoreactors/nanofactories in the context of drug delivery and artificial cells. We previously proposed design guidelines for polymers that form solute-permeable vesicles, yet we did not provide enough experimental verification. In addition, the fact that there is no clear factor for identifying permeable solutes necessitates extensive trial and error. Herein, we report solute-permeable polymer vesicles based on an amphiphilic copolymer, thermoresponsive oligosaccharide-block-poly(<i>N</i>-<i>n</i>-propylglycine). The introduction of a thermoresponsive polymer as a hydrophobic segment into amphiphilic polymers is a viable approach to construct solute-permeable polymer vesicles. We also demonstrate that the polymer vesicles are preferentially permeable to cationic and neutral fluorophores and are hardly permeable to anionic fluorophores due to the electrostatic repulsion between the bilayer and anionic fluorophores. In addition, the permeability of neutral fluorophores increases with the increasing log <i>P</i> value of the fluorophores. Thus, the electrical charge and log <i>P</i> value are important factors for membrane permeability. These findings will help researchers develop advanced nanoreactors based on permeable vesicles for a broad range of fundamental and biomedical applications.
Synthesis, Characterization, and Cu<sup>2+</sup>Coordination Studies of a 3-Hydroxy-4-pyridinone Aza Scorpiand Derivative (2016)

The synthesis, acid-base behavior, and Cu(2+) coordination chemistry of a new ligand (L1) consisting of an azamacrocyclic core appended with a lateral chain containing a 3-hydroxy-2-methyl-4(1H)-pyridinone group have been studied by potentiometry, cyclic voltammetry, and NMR and UV-vis spectroscopy. UV-vis and NMR studies showed that phenolate group was protonated at the highest pH values [log K = 9.72(1)]. Potentiometric studies point out the formation of Cu(2+) complexes of 1:2, 2:2, 4:3, 1:1, and 2:1 Cu(2+)/L1 stoichiometries. UV-vis analysis and electrochemical studies evidence the implication of the pyridinone moieties in the metal coordination of the 1:2 Cu(2+)/L1 complexes. L1 shows a stronger chelating ability than the reference chelating ligand deferiprone. While L1 shows no cytotoxicity in HeLa and ARPE-19 human cell lines (3.1-25.0 μg/mL), it has significant antioxidant activity, as denoted by TEAC assays at physiological pH. The addition of Cu(2+) diminishes the antioxidant activity because of its coordination to the pyridinone moiety phenolic group.
Organoids by design (2019)

Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in organized assembly and acquisition of tissue function. These efforts have relied on studies of organ assembly during embryonic development and have resulted in the development of organoids with multilayer tissue complexity and higher-order functions. We discuss how the next generation of organoids can be designed by means of an engineering-based narrative design to control patterning, assembly, morphogenesis, growth, and function.
MKT-077, localized lipophilic cation: antitumor activity against human tumor xenografts serially transplanted into nude mice. (1998)

The antitumor activity of MKT-077 was confirmed using human tumor xenografts in nude mice.
Feasibility and constraints of particle targeting using the antigen–antibody interaction (2013)

This work is concerned with the surface modification of fluorescent silica nanoparticles by a monoclonal antibody (M75) and the specific bioadhesion of such particles to surfaces containing the PG domain of carbonic anhydrase IX (CA IX), which is a trans-membrane protein specifically expressed on the surfaces of several tumor cell lines. The adhesion strength of antibody-bearing silica nanoparticles to antigen-bearing surfaces was investigated under laminar flow conditions in a microfluidic cell and compared to the adhesion of unmodified silica nanoparticles and nanoparticles coupled with an unspecific antibody. Adhesion to cancer cells using flow cytometry was also investigated and in all cases the adhesion strength of M75-modified nanoparticles was significantly stronger than for the unmodified or unspecific nanoparticles, up to several orders of magnitude in some cases. The specific modification of nano- and microparticles by an antibody-like protein therefore appears to be a feasible approach for the targeting of tumor cells.
Phase I study of CC-90010, a reversible, oral BET inhibitor in patients with advanced solid tumors and relapsed/refractory non-Hodgkin's lymphoma (2020)

CC-90010 is well tolerated, with single-agent activity in patients with heavily pretreated, advanced solid tumors.
Design of Secure User Authenticated Key Management Protocol for Generic IoT Networks (2017)

In recent years, the research in generic Internet of Things (IoT) attracts a lot of practical applications including smart home, smart city, smart grid, industrial Internet, connected healthcare, smart retail, smart supply chain and smart farming. The hierarchical IoT network (HIoTN) is a special kind of the generic IoT network, which is composed of the different nodes, such as the gateway node, cluster head nodes, and sensing nodes organized in a hierarchy. In HIoTN, there is a need, where a user can directly access the real-time data from the sensing nodes for a particular application in generic IoT networking environment. This paper emphasizes on the design of a new secure lightweight three-factor remote user authentication scheme for HIoTNs, called the user authenticated key management protocol (UAKMP). The three factors used in UAKMP are the user smart card, password, and personal biometrics. The security of the scheme is thoroughly analyzed under the formal security in the widely accepted real-or-random model, the informal security as well as the formal security verification using the widely accepted automated validation of Internet security protocols and applications tool. UAKMP offers several functionality features including offline sensing node registration, freely password and biometric update facility, user anonymity, and sensing node anonymity compared to other related existing schemes. In addition, UAKMP is also comparable in computation and communication costs as compared to other existing schemes.
Effects of weathering on fabrics treated with permethrin for protection against mosquitoes. (1989)

Permethrin-impregnated and untreated fabrics were evaluated for their toxic and repellent effects against Anopheles stephensi and Aedes aegypti after both types of fabrics were subjected to accelerated weathering for 9 weeks, under a simulated wet/tropical environment. The toxic (knockdown) effect of permethrin-impregnated fabrics against both species of mosquitoes diminished rapidly after 1 week compared to the repellent effect. After 6 weeks of weathering, the remaining low amounts of permethrin provided fair protection from mosquito bites; however, no knockdown was observed at those levels. Permethrin-treated fabric was effective in providing protection from mosquito bites and appears to be a means of attenuating both the nuisance effects and, possibly, disease transmission by mosquitoes.
Phylogenetic analysis of a natural marine bacterioplankton population by rRNA gene cloning and sequencing (1991)

The identification of the prokaryotic species which constitute marine bacterioplankton communities has been a long-standing problem in marine microbiology. To address this question, we used the polymerase chain reaction to construct and analyze a library of 51 small-subunit (16S) rRNA genes cloned from Sargasso Sea bacterioplankton genomic DNA. Oligonucleotides complementary to conserved regions in the 16S rDNAs of eubacteria were used to direct the synthesis of polymerase chain reaction products, which were then cloned by blunt-end ligation into the phagemid vector pBluescript. Restriction fragment length polymorphisms and hybridizations to oligonucleotide probes for the SAR11 and marine Synechococcus phylogenetic groups indicated the presence of at least seven classes of genes. The sequences of five unique rDNAs were determined completely. In addition to 16S rRNA genes from the marine Synechococcus cluster and the previously identified but uncultivated microbial group, the SAR11 cluster [S. J. Giovannoni, T. B. Britschgi, C. L. Moyer, and K. G. Field. Nature (London) 345:60-63], two new gene classes were observed. Phylogenetic comparisons indicated that these belonged to unknown species of alpha- and gamma-proteobacteria. The data confirm the earlier conclusion that a majority of planktonic bacteria are new species previously unrecognized by bacteriologists.
Myocardial tagging with SSFP (2003)

This work presents the first implementation of myocardial tagging with refocused steady-state free precession (SSFP) and magnetization preparation. The combination of myocardial tagging (a noninvasive method for quantitative measurement of regional and global cardiac function) with the high tissue signal-to-noise ratio (SNR) obtained with SSFP is shown to yield improvements in terms of the myocardium-tag contrast-to-noise ratio (CNR) and tag persistence when compared to the current standard fast gradient-echo (FGRE) tagging protocol. Myocardium-tag CNR and tag persistence were studied using numerical simulations as well as phantom and human experiments. Both quantities were found to decrease with increasing imaging flip angle (alpha) due to an increased tag decay rate and a decrease in myocardial steady-state signal. However, higher alpha yielded better blood-myocardium contrast, indicating that optimal alpha is dependent on the application: higher alpha for better blood-myocardium boundary visualization, and lower alpha for better tag persistence. SSFP tagging provided the same myocardium-tag CNR as FGRE tagging when acquired at four times the bandwidth and better tag- and blood-myocardium CNRs than FGRE tagging when acquired at equal or twice the receiver bandwidth (RBW). The increased acquisition efficiency of SSFP allowed decreases in breath-hold duration, or increases in temporal resolution, as compared to FGRE.
An Accurate Worst Case Timing Analysis for RISC Processors (1995)

An accurate and safe estimation of a task&apos;s worst case execution time (WCET) is crucial for reasoning about the timing properties of real-time systems. In RISC processors, the execution time of a program construct (e.g., a statement) is affected by various factors such as cache hits/misses and pipeline hazards, and these factors impose serious problems in analyzing the WCETs of tasks. To analyze the timing effects of RISC&apos;s pipelined execution and cache memory, we propose extensions to the original timing schema where the timing information associated with each program construct is a simple time-bound. In our approach, associated with each program construct is what we call a WCTA (Worst Case Timing Abstraction), which contains detailed timing information of every execution path that might be the worst case execution path of the program construct. This extension leads to a revised timing schema that is similar to the original timing schema except that concatenation and pruning operation...
쿠마 켄고 건축공간에서 나타나는 재료물성의 감각성 표현 연구 (2019)

본 연구는 재료의 감각성을 키워드로, 쿠마 켄고(Kengo kuma) 건축공간의 표현적 특성과 구축성의 의미간의 관계를 탐구한다. 건축가 쿠마 켄고는 구축성의 의미를 인식하여 자신의 건축적 철학을 견지한다. 이를 바탕으로 재료의 감각성을 공간으로 표현하는 실무가이다. 따라서 본 연구는 쿠마 켄고 공간에서 나타나는 재료 감각성의 표현과 그가 인식하고 있는 구축성의 의미와의 관계성을 탐구하고자 하였다.
Polymer-based dry electrodes for high user comfort ECG/EEG measurements (2014)

Conventional ECG and EEG gel electrodes are widely used in health care applications. These electrodes deliver high-quality signals due to their low impedance, but they have important drawbacks, such as time-consuming electrode set-up for EEG followed by a painful removal, skin irritation by the gel, signal degradation due to drying of the gel, etc. To solve this, various types of dry electrodes attract attention last years. Hard metal dry electrodes show low impedance, but most are not comfortable for the patient. Flexible polymer-based electrodes are presented in this work to avoid the disadvantages of gel electrodes while significantly improving user comfort. Different additives are mixed in these polymers and optimized to improve various relevant properties. An important electrode property is low impedance, which directly affects signal quality and influences the sensitivity to motion artifacts. The polymer composition influences also the mechanical properties, as well as the material flow during molding and hence the electrode fabrication yield. Moreover, various electrode shapes are tested to achieve appropriate mechanical properties and increase user comfort. For ECG & EEG applications, the best performing dry electrodes are selected and results are compared with wet electrode signals .
Measured relationship between thermodynamic pressure and refractivity for six candidate gases in laser barometry (2019)

Laser refractometers are approaching accuracy levels where gas pressures in the range 1 Pa < <i>p</i> < 1 MPa inferred by measurements of gas refractivity at a known temperature will be competitive with the best existing pressure standards and sensors. Here, the authors develop the relationship between pressure and refractivity <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>p</mml:mi> <mml:mo>=</mml:mo> <mml:msub><mml:mi>c</mml:mi> <mml:mn>1</mml:mn></mml:msub> <mml:mo>⋅</mml:mo> <mml:mo>(</mml:mo> <mml:mi>n</mml:mi> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> <mml:mo>)</mml:mo> <mml:mo>+</mml:mo> <mml:msub><mml:mi>c</mml:mi> <mml:mn>2</mml:mn></mml:msub> <mml:mo>⋅</mml:mo> <mml:msup><mml:mrow><mml:mo>(</mml:mo> <mml:mi>n</mml:mi> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> <mml:mo>)</mml:mo></mml:mrow> <mml:mn>2</mml:mn></mml:msup> <mml:mo>+</mml:mo> <mml:msub><mml:mi>c</mml:mi> <mml:mn>3</mml:mn></mml:msub> <mml:mo>⋅</mml:mo> <mml:msup><mml:mrow><mml:mo>(</mml:mo> <mml:mi>n</mml:mi> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> <mml:mo>)</mml:mo></mml:mrow> <mml:mn>3</mml:mn></mml:msup> <mml:mo>+</mml:mo> <mml:mo>⋯</mml:mo></mml:mrow> </mml:math> , via measurement at <i>T =</i> 293.1529(13) K and <i>λ</i> = 632.9908(2) nm for <i>p</i> ≤ 500 kPa. The authors give values of the coefficients <i>c</i> <sub>1</sub>, <i>c</i> <sub>2</sub>, <i>c</i> <sub>3</sub> for six gases: Ne, Ar, Xe, N<sub>2</sub>, CO<sub>2</sub>, and N<sub>2</sub>O. For each gas, the resulting molar polarizability <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow><mml:msub><mml:mi>A</mml:mi> <mml:mi>R</mml:mi></mml:msub> <mml:mo>≡</mml:mo> <mml:mfrac><mml:mrow><mml:mn>2</mml:mn> <mml:mi>R</mml:mi> <mml:mi>T</mml:mi></mml:mrow> <mml:mrow><mml:mn>3</mml:mn> <mml:msub><mml:mi>c</mml:mi> <mml:mn>1</mml:mn></mml:msub> </mml:mrow> </mml:mfrac> </mml:mrow> </mml:math> has a standard uncertainty within 16 × 10<sup>-6</sup>·<i>A</i> <sub><i>R</i></sub> . In these experiments, pressure was realized via measurements of helium refractivity at a known temperature: for He, the relationship between pressure and refractivity is known through calculation much more accurately than it can presently be measured. This feature allowed them to calibrate a pressure transducer <i>in situ</i> with helium and subsequently use the transducer to accurately gage the relationship between pressure and refractivity on an isotherm for other gases of interest.
Automatic segmentation and recognition of zip codes on handwritten real mail (1989)

The authors combine statistical and structural techniques for automatic segmentation and recognition of zip codes. This kind of combination has been advocated by several authors. The aim is to incorporate advantages of both approaches, that is to say, the flexibility and the adaptability to noisy patterns, for statistical techniques, and possibility to describe very complex and specific patterns, using syntactic techniques. The statistical stage is the first and main stage of the authors recognition system. It uses concavity measurements to characterize the characters and a linear discrimination technique is implemented to affect one character to one cluster. The second stage, called structural supervisor, is developed in order to control and improve the results of the first stage. >