gebhart/patrepeval huggingface dataset:
<i>F8</i> haplotype and inhibitor risk: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort (2012)

Ancestral background, specifically African descent, confers higher risk for development of inhibitory antibodies to factor VIII (FVIII) in haemophilia A. It has been suggested that differences in the distribution of FVIII gene (F8) haplotypes, and mismatch between endogenous F8 haplotypes and those comprising products used for treatment could contribute to risk. Data from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort were used to determine the association between F8 haplotype 3 (H3) vs. haplotypes 1 and 2 (H1 + H2) and inhibitor risk among individuals of genetically determined African descent. Other variables known to affect inhibitor risk including type of F8 mutation and human leucocyte antigen (HLA) were included in the analysis. A second research question regarding risk related to mismatch in endogenous F8 haplotype and recombinant FVIII products used for treatment was addressed. Haplotype 3 was associated with higher inhibitor risk among those genetically identified (N = 49) as of African ancestry, but the association did not remain significant after adjustment for F8 mutation type and the HLA variables. Among subjects of all racial ancestries enrolled in HIGS who reported early use of recombinant products (N = 223), mismatch in endogenous haplotype and the FVIII proteins constituting the products used did not confer greater risk for inhibitor development. Haplotype 3 was not an independent predictor of inhibitor risk. Furthermore, our findings did not support a higher risk of inhibitors in the presence of a haplotype mismatch between the FVIII molecule infused and that of the individual.
Simultaneous combination of microtubule depolymerizing and stabilizing agents acts at low doses (1995)

The combined activity of a stabilizing and a depolymerizing agent was studied on microtubule formation in vitro and on cellular parameters related to the cytoskeleton. New compounds in each class of microtubular drugs, docetaxel, as stabilizing agent, and CI 980, as colchicine analog, currently in clinical trials, were tested at high and low concentrations. Simultaneous combination of docetaxel and CI 980, both in vitro and in cell lines, induced microtubule structures resulting from the association of the effects of the two drugs: short and numerous microtubules in vitro, abnormal asters or short bundles in cells depolymerized in their periphery. Moreover, combining the two drugs at low concentrations inducing neither modification of the microtubular network nor variation in cell polymerized tubulin content showed synergistic effects in mitotic cell block and, at lower concentrations, in inhibition of proliferation in the KB 3-1 cell line. Similar qualitative results were obtained with paclitaxel and colcemid, used in the place of docetaxel and CI 980, respectively. At low doses, the taxoid/colchine analog combination seems to induce some degree of mitotic inhibition, resulting from a subtle effect on the inhibition of microtubule dynamics.
Edible oleogels: an opportunity for fat replacement in foods (2018)

The scientific and industrial communities have been giving great attention to the development of new bio-based materials with potential use in innovative technological applications. Among these materials are the structures with gel-like behavior that can be used in the cosmetic, pharmaceutical and food industries, aiming at controlling the physical properties of the final products. In the past ten years, words like oleogels and organogels have been increasingly used, the existing number of manuscripts and patents being proof of this tendency. In the food industry, oleogels can be used to control phase separation, and decrease the mobility and migration of the oil phase, providing solid-like properties without using high levels of saturated fatty acids as well as to be a carrier of bioactive compounds. In most cases, their main features are related to the reorganization process of gelators after an increase of the temperature, above the melting or glass transition temperature of the materials, known as the direct method, but it is also possible to develop oleogels by indirect methods, such as emulsification and the solvent exchange technique. In the direct methods, the reorganization is able to physically entrap oil leading to different physicochemical properties, the rheological behavior and texture properties being the frequently most studied ones. This review overviews the use of food grade and bio-based structurants to produce edible oleogels, aiming at fat replacement and structure-tailoring. Gelation mechanisms and oil phases used during oleogel production are discussed, as well as the current food applications and future trends for this kind of structure.
Mind the Gap: A Well Log Data Analysis (2017)

The main task in oil and gas exploration is to gain an understanding of the distribution and nature of rocks and fluids in the subsurface. Well logs are records of petro-physical data acquired along a borehole, providing direct information about what is in the subsurface. The data collected by logging wells can have significant economic consequences, due to the costs inherent to drilling wells, and the potential return of oil deposits. In this paper, we describe preliminary work aimed at building a general framework for well log prediction. First, we perform a descriptive and exploratory analysis of the gaps in the neutron porosity logs of more than a thousand wells in the North Sea. Then, we generate artificial gaps in the neutron logs that reflect the statistics collected before. Finally, we compare Artificial Neural Networks, Random Forests, and three algorithms of Linear Regression in the prediction of missing gaps on a well-by-well basis.
Frontier of therapeutic antibody discovery: The challenges and how to face them (2012)

Therapeutic monoclonal antibodies have become an important class of modern medicines. The established technologies for therapeutic antibody discovery such as humanization of mouse antibodies, phage display of human antibody libraries and transgenic animals harboring human IgG genes have been practiced successfully so far, and many incremental improvements are being made constantly. These methodologies are responsible for currently marketed therapeutic antibodies and for the biopharma industry pipeline which are concentrated on only a few dozen targets. A key challenge for wider application of biotherapeutic approaches is the paucity of truly validated targets for biotherapeutic intervention. The efforts to expand the target space include taking the pathway approach to study the disease correlation. Since many new targets are multi-spanning and multimeric membrane proteins there is a need to develop more effective methods to generate antibodies against these difficult targets. The pharmaceutical properties of therapeutic antibodies are an active area for study concentrating on biophysical characteristics such as thermal stability and aggregation propensity. The immunogenicity of biotherapeutics in humans is a very complex issue and there are no truly predictive animal models to rely on. The in silico and T-cell response approaches identify the potential for immunogenicity; however, one needs contingency plans for emergence of anti-product antibody response for clinical trials.
High range resolution based on multi-carrier-frequency MIMO radar (2009)

Multi-Carrier-Frequency MIMO (MCF MIMO) Radar is a radar system with multiple transmit antennas and multiple receive antennas capitalizing on frequency diversity and spatial diversity to obtain orthogonality of transmitted signals and it can combine a number of narrow bandwidth signals to form a large bandwidth signal to obtain high range resolution(HRR). Two processing methods based on dechirp processing and channel separation technique to obtain the HRR, which are respectively IDFT Coherent Synthesis method (short for ICS method) and Spatial Domain Synthetic Bandwidth method (short for SDSB method), are proposed in the paper. Also both methods are characterized by the reduction of the instantaneous bandwidth and slightly influence on the moving target. Finally the simulation results on the computer validate these conclusions. (4 pages)
Seven new metabolites of drostanolone heptanoate by using <i>Beauveria bassiana</i>, and <i>Macrophomina phaseolina</i> cell suspension cultures (2020)

The present study reports the biotransformation of an anabolic-androgenic steroid (AAS) drostanolone heptanoate (1) by using two microbial cultures, <i>Beauveria bassiana</i>, and <i>Macrophomina phaseolina</i>. Fermentation of 1 with <i>B. bassiana</i> yielded five new transformed products 2-6, while with <i>M. phaseolina</i> it afforded two new 7-8, and two known 9-10 metabolites. The main sites of hydroxylation in the steroidal skeleton of 1 were at C-5, C-7, C-11, C-14, C-15, and C-20, hydrolysis of the ester moiety at C-17, and reduction of the carbonyl group at C-3. The structures of the transformed products were determined by using mass, NMR, and other spectroscopic techniques.
Generation of audible sound with ultrasonic signals through the human body (2012)

This paper presents an innovative hearing system. The hearing system generates audible sound in the ears without any receivers, and no one can hear the generated sound except the user. The theory for generating audible sound is based on a self-demodulation effect which arises from the nonlinearity of the transmission medium. The nonlinear acoustics of the human body allow ultrasonic waves to interact in the transmission medium. When two ultrasonic waves with different frequencies are transmitted through the human body, an audio signal at the difference frequency of two waves is produced in the ears due to the self-demodulation effect.
A hybrid surfacing methodology for reverse engineering (2009)

The aim of this paper is to propose a new hybrid surfacing methodology which could result in a faster high-quality surface reconstruction. After reviewing the state-of-the-art reverse modelling techniques, the two methodologies of classic surfacing based on typical procedure of point-curve-surface and rapid surfacing based on polygonised mesh grids are presented. The fundamentals involved in these two methodologies are analysed. Then a new hybrid surfacing methodology based on feature template is proposed. As for hybrid surfacing, rapid surfacing is used firstly to polygonise the point cloud to extract the feature template with quadrilateral parameterisation type, then the feature template is given further treatment in the classic surfacing system to construct the surface model. It can not only efficiently overcome the drawback of curvature continuity in rapid surfacing, but also reduce the difficulty of data segmentation in classic surfacing, making faster high-quality surface approximation possible.
70.4L: <i>Late‐News Paper</i> : 0.5‐inch XGA Micro‐OLED Display on a Silicon Backplane with High‐Definition Technologies (2012)

Abstract We have developed a high‐definition (0.5‐inch XGA) Micro‐OLED display that employs high‐definition technologies, including a new pixel driving circuit and a high‐efficiency top‐emitting white OLED device with a color filter. These technologies were incorporated in the world's first XGA OLED electronic viewfinder for digital single‐lens cameras and HD‐personal 3D viewer with two 720p Micro‐OLED displays.
Macropore Formation Without Illumination on Low Doped n-Type Silicon (2007)

Based on the current-burst-model, it is possible to obtain macropores even in low-doped n-type silicon without illumination. In this study, HF-containing electrolytes were systematically modulated with strong oxidants. Etching in the dark with low current densities, macropores with depths up to and pore-diameters between and were produced on low-doped n-type silicon where systematical macropore-formation without illumination has not been previously reported. In two cases, cylindrical pores with rather smooth walls were observed, and in several other cases, the noninterconnected pores were weakly- branched and thus had a distinct difference with classical heavily branched n-mesopores. By geometrical definition and morphological characterization, such pores could be termed "macropores" and thereby the current-burst-model was applied to interpret the mechanism concerning macropore formation.
Thermal conductivity of diamond-like carbon films (2006)

The authors report the thermal conductivity (K) of a variety of carbon films ranging from polymeric hydrogenated amorphous carbons (a-C:H) to tetrahedral amorphous carbon (ta-C). The measurements are performed using the 3ω method. They show that thermal conduction is governed by the amount and structural disorder of the sp3 phase. If the sp3 phase is amorphous, K scales linearly with the C–C sp3 content, density, and elastic constants. Polymeric and graphitic films have the lowest K (0.2–0.3W∕mK), hydrogenated ta-C:H has K∼1W∕mK, and ta-C has the highest K (3.5W∕mK). If the sp3 phase orders, even in small grains such as in micro- or nanodiamond, a strong K increase occurs for a given density, Young’s modulus, and sp3 content.
Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus (2017)

BT is a useful, inexpensive, simple and safe diagnostic test in the evaluation of common gastroenterology problems. These consensus statements should help to standardize the indications, preparation, performance and interpretation of BT in clinical practice and research.
Secondary Extinction Used in Thickness and Pole Density Measurements of Textured Films by X-Ray Diffraction (1998)

A new X-ray diffraction method for a more accurate determination of film thickness and pole densities is developed by introducing a secondary extinction correction. For the purpose an equation based on the kinematic theory of X-ray diffraction and the mosaic crystal model has been derived. The discussion of results shows that the correct characterization of textured films requires in general the secondary extinction to be taken into account.
Dark-Pulse Propagation in Optical Fibers (1988)

We report measurements of the reshaping of 0.3-psec dark pulses due to their passage through 10 m of single-mode optical fiber. The measurements were performed as a function of intensity and the observed strong reshaping agrees qualitatively with the predictions of the nonlinear Schr\"odinger equation which suggest that we have observed the formation of dark-pulse solitons.
Ultrasensitive DNA Detection Using Highly Fluorescent Bioconjugated Nanoparticles (2003)

Sensitive DNA detection is extremely important in clinical diagnostics, gene therapy, and a variety of biomedical studies. We have developed a novel DNA bioanalysis method with a 0.8 fM (0.8 x 10-15 M) detection limit using a bioconjugated fluorescent nanoparticle-based sandwich assay. An organic dye silica nanoparticle is synthesized using a modified reverse microemulsion. The nanoparticles are highly fluorescent, extremely photostable, and easy for bioconjugation for bioanalysis. They exhibit an excellent signaling ability in the presence of trace amounts of DNA targets. With an effective surface modification, nonspecific binding and nanoparticle aggregation are minimized. In addition, the nanoparticle-based DNA bioanalysis assay can effectively discriminate one-base mismatched DNA sequences. We expect this nanoparticle-based assay to be widely useful in a number of biomedical applications where reproducible, selective, and ultrasensitive gene analysis is critical.
I2MeDS: Intelligent Integrated Medical Data System (2008)

Miniaturization of computing devices and advances in wireless communication have fueled interest in the development of new and innovative applications in many fields, including medical diagnosis, environmental monitoring, and industrial applications. Although medical instruments have benefited a great deal from the technological advances in past decades, many practices and day-to-day activities in medical environments remain virtually unchanged. Due to concerns about security and reliability of new technologies, penetration of IT advancements into the medical domain remains a challenge. This paper shows how healthcare can benefit significantly from incorporating various IT developments, particularly wireless technologies. Proposed here is a new model for utilizing wireless technology to address key issues in medical environments, such as monitoring and tracking medical assets and detecting/preventing errors during medication administration. The proposed Intelligent Integrated Medical Data System (I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> MeDS) is based on the development of a secure and reliable network infrastructure with a unified database management system.
First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE<sub>2</sub>-receptor E-type 4 (EP4), in patients with advanced cancers (2020)

NCT02540291.
Reservoir Characterization: A Machine Learning Approach (2015)

Reservoir Characterization (RC) can be defined as the act of building a reservoir model that incorporates all the characteristics of the reservoir that are pertinent to its ability to store hydrocarbons and also to produce them.It is a difficult problem due to non-linear and heterogeneous subsurface properties and associated with a number of complex tasks such as data fusion, data mining, formulation of the knowledge base, and handling of the uncertainty.This present work describes the development of algorithms to obtain the functional relationships between predictor seismic attributes and target lithological properties. Seismic attributes are available over a study area with lower vertical resolution. Conversely, well logs and lithological properties are available only at specific well locations in a study area with high vertical resolution.Sand fraction, which represents per unit sand volume within the rock, has a balanced distribution between zero to unity.The thesis addresses the issues of handling the information content mismatch between predictor and target variables and proposes regularization of target property prior to building a prediction model.In this thesis, two Artificial Neural Network (ANN) based frameworks are proposed to model sand fraction from multiple seismic attributes without and with well tops information respectively. The performances of the frameworks are quantified in terms of Correlation Coefficient, Root Mean Square Error, Absolute Error Mean, etc.
In1−<i>x</i>Ga<i>x</i>P1−<i>z</i>As<i>z</i> double-heterojunction-laser operation (77 °K, yellow) in an external grating cavity (1976)

In1−xGaxP1−zAsz double-heterojunction lasers fabricated by liquid-phase epitaxy are operated at λ ≲6000 Å (77 °K) in an external grating cavity to provide wavelength-selective optical feedback. Diodes with and without antireflecting coatings and with heterobarrier heights of ∼20, ∼65, and ∼90 meV are examined. With external grating feedback, laser operation occurs at reduced threshold current densities and narrower linewidths and, depending upon heterobarrier height, can be tuned over an appreciable wavelength range. Within certain tuning limits on either side of line center, the carrier recombination is drawn to the grating wavelength and, as in earlier work, laser operation on a homogeneously broadened line is observed. Beyond these limits, particularly for excitation just above the threshold of stimulated emission, laser operation on an inhomogeneously broadened line can be distinguished. These observations showing that homogeneous and inhomogeneous line broadening occur in a semiconductor laser are accounted for by a simple model of the recombination kinetics.
Biocatalytic resolutions of .alpha.-methylene-.beta.-hydroxy esters and ketones (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiocatalytic resolutions of .alpha.-methylene-.beta.-hydroxy esters and ketonesKevin Burgess and Lee D. JenningsCite this: J. Org. Chem. 1990, 55, 4, 1138–1139Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/jo00291a006https://doi.org/10.1021/jo00291a006research-articleACS PublicationsRequest reuse permissionsArticle Views251Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy (2020)

The last two decades have seen a revival of interest in the entactogen 3,4-methylenedioxy-N-methylamphetamine (MDMA) as an adjunct to psychotherapy, particularly for the treatment of post-traumatic stress disorder. While clinical results are highly promising, and MDMA is expected to be approved as a treatment in the near future, it is currently the only compound in its class of action that is being actively investigated as a medicine. This lack of alternatives to MDMA may prove detrimental to patients who do not respond well to the particular mechanism of action of MDMA or whose treatment calls for a modification of MDMA's effects. For instance, patients with existing cardiovascular conditions or with a prolonged history of stimulant drug use may not fit into the current model of MDMA-assisted psychotherapy, and could benefit from alternative drugs. This review examines the existing literature on a host of entactogenic drugs, which may prove to be useful alternatives in the future, paying particularly close attention to any neurotoxic risks, neuropharmacological mechanism of action and entactogenic commonalities with MDMA. The substances examined derive from the 1,3-benzodioxole, cathinone, benzofuran, aminoindane, indole and amphetamine classes. Several compounds from these classes are identified as potential alternatives to MDMA.
Reliability-based computational model for material development and structural design (2001)

This paper discusses a methodology to aid in the design and to predict the reliability of metallic components using probabilistic microstructural fatigue models. The capabilities are aimed at predicting the variation in fatigue life based on the statistical variation of the microstructure of the material. Material parameters at metallic grain level are used along with fundamental physics-based models to predict the damage as it accumulates. The methods use a virtual prototyping technique relying on computer simulation of real material behaviour. The computer simulates many "identical" components, but uses a different sample of material microstructure for each simulation. The microstructure of each simulated component is properly sampled from the specified range of material parameters. Each of the components is then virtually tested using computer models to simulate real-world usage conditions. The virtual testing allows the "gathering" of data on thousands or even millions of components.