gebhart/patrepeval huggingface dataset:
Abstract 2871: Saddle-Shaped Annuloplasty Reduces Mitral Leaflet Stress: A Real-Time 3D Echocardiographic Study (2008)

Objectives: High leaflet and chordal stresses contribute to recurrent mitral regurgitation after repair procedures. We hypothesized that a saddle-shaped annuloplasty ring would reduce leaflet stress compared to a similarly sized flat annuloplasty ring. To test this hypothesis we used a novel 3D echocardiographically-based finite element modeling (FEM) technique for quantifying regional mitral valve stress. Methods: Real-time 3D echocardiography was performed in 8 sheep before and after placement of either a 30mm flat annuloplasty (n=4) or a 30mm saddle-shaped annuloplasty. Full-volume data sets of the MV were obtained using an IE33 platform(Philips Medical Systems, Andover, Massachusetts) and exported to Cardio-View (Tomtec Imaging Systems, Munich, Germany) for image analysis. Individual leaflet data were then interpolated using Matlab (The Mathworks, Natick, Massachusetts). Triangulated leaflet surfaces were extracted and the data imported into a commercial finite element program (ABAQUS/Explicit 6.3, HKS Inc. Pawtucket, RI) to quantify regional stress distributions in all segments (P1, P2, P3 and A1, A2, A3) of the MV. Results: Peak anterior and posterior leaflet stresses after flat annuloplasty placement were 0.20±0.001MPa and 21±0.02MPa. Peak anterior and posterior leaflet stress after saddle-shaped annuloplasty placement was 0.19±0.02MPa and 13±0.01MPa (p<0.05 for the posterior leaflet stresses) Conclusions: Saddle-shaped annuloplasty design results in greater stress reduction in the posterior leaflet than standard flat annuloplasty rings and may, therefore, result in more durable repairs. This research has received full or partial funding support from the American Heart Association, AHA Great Rivers Affiliate (Delaware, Kentucky, Ohio, Pennsylvania & West Virginia).
Spatiotemporal modulation for non-reciprocal radiation and scattering (2016)

Lorentz reciprocity imposes constraints on radiation and scattering. For instance, a reciprocal antenna in a reciprocal medium will have identical radiation patterns in transmission and reception; therefore, in a dense environment a directive antenna will be prone to `hear' its own echoes. Likewise, a scattering matrix in reciprocal medium will be symmetric, implying particularly that a metasurface that reflects plane wave A to plane wave B will necessarily do the reciprocal process, from B to A, with identical efficiency. Recent works have shown that weak spatiotemporal modulation in high-Q ring resonators can create drastic non-reciprocity. Here we show theoretically and experimentally that, by proper design, taking advantage of the light-cone filtering property, spatiotemporal modulation of low-Q radiating and scattering systems, can exhibit also significant non-reciprocity. Possible applications are in radio-frequency communication systems, as well as open new directions in nanophotonics, energy harvesting, and thermal management, when translated to different frequency regimes.
C-O Bond Formation by Polyketide Synthases (2002)

Polyketide synthases (PKSs) assemble the polyketide carbon backbone by sequential decarboxylative condensation of acyl coenzyme A (CoA) precursors, and the C-C bond-forming step in this process is catalyzed by the beta-ketoacyl synthase (KS) domain or subunit. Genetic and biochemical characterization of the nonactin biosynthesis gene cluster from Streptomyces griseus revealed two KSs, NonJ and NonK, that are highly homologous to known KSs but catalyze sequential condensation of the acyl CoA substrates by forming C-O rather than C-C bonds. This chemistry can be used in PKS engineering to increase the scope and diversity of polyketide biosynthesis.
TML+ Tactical Medical Logistics Planning Tool Version 2.0 User's Guide (2004)

The Tactical Medical Logistics Planning Tool (TML+) is a software program designed for Navy and Marine Corps medical planners as a tool that (1) models the patient flow from the point of injury through more definitive care and (2) supports operations research and systems analysis studies operational risk assessment and field medical services planning. The manual is divided into seven chapters. Chapter 1 provides background information explains the development of TML+ and discusses why TML+ is important. Chapter 2 provides an overview of TML+ as well as in-depth instructions for basic program operations. Chapter 3 explains how to select a scenario while Chapter 4 describes how to set up your casualty streams. Chapter 5 outlines how to identify the levels of care you expect to provide treatment for your patients. Chapter 6 explains how to insert the transportation assets for your network of care facilities. Chapter 7 explains how to generate reports and interpret them most effectively. In addition an at-a-glance set of directions for running TML+ is located at the back of this guide.
Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (2017)

The metabotropic glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson's disease (PD). However, since the discovery of its therapeutic potential, no ligand has been successfully developed enough to be tested in the clinic. In the present paper, we report for the first time the medicinal chemistry efforts conducted around the pharmacological tool (-)-PHCCC. This work led to the identification of compound 40, a potent and selective mGluR4 positive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclinical rodent models of PD motor symptoms after intraperitoneal administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model. Moreover, we also describe the identification of compound 60 a close analogue of compound 40 with improved pharmacokinetic profile after oral administration. On the basis of its favorable and unique preclinical profile, compound 60 (PXT002331, now foliglurax) was nominated as a candidate for clinical development.
Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice (2013)

These results suggest that GTE+γ-PGA treatment than GTE or γ-PGA alone may be a useful tool for preventing both obesity and obesity-induced T2DM.
Alkaliphiles: Ecology, diversity and applications (1990)

Organisms with pH optima for growth in excess of pH8, usually between 9 and 10, are properly defined as alkaliphiles (or sometimes alkalophiles). Most of the organisms described to date as growing under very alkaline conditions are prokaryotes, comprising a heterogeneous collection of eubacteria (including cyanobacteria) with a few examples of archaebacteria. With the exception of the alkaliphilic archaebacteria (which are also halophilic), few of the isolates have been comprehensively classified. However, it is clearly that may different taxa are represented amongst the alkaliphiles, and that some of these at least are likely to be new taxa. Alkaliphiles can be isolated from ‘normal’ environments such as garde soil, presumably because there are transient alkaline conditions generated in such environments by biological activity, but a relatively restricted range of types results from the exploration of such environments (often Bacillus spp.). Naturally-occurring stable alkaline environments such as eutrophic soda (Na2CO3) lakes harbour a much wider range of types. A similarity wide range of types may exist in oligotrophic Ca(OH)2-dominated ground water in certain parts of the world. Alkaliphilic microorganisms have already made a large impact in the application of biotechnology for the manufacture of mass market consumer products. “Biological detergents” contain enzymes that have usually been obtained from alkaliphilic or alkalitolerant bacteria. The current proportion of total world enzyme production destined for the laundry detergents market comfortably exceeds 25%, and there are other possible applications in food and waste treatment industies. To date, most commercially available enzymes are derived from a few bacterial taxa (notably Bacillus spp.) and we have been very conservative in our choice of environments in which to look for new products. It is reasonable to suppose that soda lakes (and other alkaline environments) will yield a wealth of new organisms with useful commercial properties.
INDEPENDENT VARIATION IN NATURE OF HEMAGGLUTININ AND NEURAMINIDASE ANTIGENS OF INFLUENZA VIRUS: DISTINCTIVENESS OF HEMAGGLUTININ ANTIGEN OF HONG KONG/68 VIRUS (1969)

Antigenic variations of the two virus-coded surface proteins of influenza virus-hemagglutinin and neuraminidase-were examined in seven strains of influenza A(2) virus (including the Hong Kong/68 strain) isolated from 1957 to 1968. Changes in the two antigens were found to occur independently in nature, resulting in new viruses which differ from older strains more with respect to one antigen than the other. The Hong Kong/68 strain is markedly different from previous A(2) strains in its hemagglutinin antigen but possesses neuraminidase indistinguishable antigenically from that of recent strains. Immunization experiments in mice provided evidence that only the neuraminidase component of an earlier A(2) strain provided protection against Hong Kong virus challenge. Segregation of hemagglutinin and neuraminidase antigens through recombination of each of the seven strains of influenza A(2) virus with A(0)/NWS virus made it possible to investigate antigenic variation of the two dissociated surface proteins independently in a common plaque assay system. Comparison of these hybrid viruses with the parent A(2) strains provided evidence that all the cross-reactivity of the Hong Kong strain with previous A(2) viruses is explicable on the basis of its similar neuraminidase component. It is proposed that the taxonomy of influenza A viruses must take into account differences in neuraminidase as well as hemagglutinin antigens.
Differential Regulation of the p80 Tumor Necrosis Factor Receptor in Human Obesity and Insulin Resistance (1997)

Previous studies have shown that tumor necrosis factor (TNF)-alpha production from adipose tissue is elevated in rodent and human obesity and plays an important role in insulin resistance in experimental animal models. In this study, we examined the adipose expression of both TNF receptors (TNFR1 and TNFR2) in human obesity and demonstrated that obese female subjects express approximately twofold more TNFR2 mRNA in fat tissue and approximately sixfold more soluble TNFR2 in circulation relative to lean control subjects. In contrast, TNFR1 expression and protein levels were similar in these subjects. TNFR2 expression levels in adipose tissue were strongly correlated with BMI (r = 0.65, P < 0.001) and level of hyperinsulinemia (P < 0.001), an indirect measure of insulin resistance, as well as level of TNF-alpha mRNA expression in fat tissue (r = 0.56, P < 0.001). These results suggest that TNFR2 might play a role in human obesity by modulating the actions of TNF-alpha.
Is (+)-[ <sup>13</sup> C]-pantoprazole better than (±)-[ <sup>13</sup> C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity? (2012)

Recently, we have shown that the (+)-[(13)C]-pantoprazole is more dependent on CYP2C19 metabolic status than (-)-[(13)C]-pantoprazole. In this study, we tested the hypothesis that (+)-[(13)C]-pantoprazole is a more sensitive and selective probe for evaluating CYP2C19 enzyme activity than the racemic mixture. (+)-[(13)C]-pantoprazole (95 mg) was administered orally in a sodium bicarbonate solution to healthy volunteers. Breath and plasma samples were collected before and up to 720 min after dosing. The (13)CO2 in exhaled breath samples was measured by infrared spectrometry. Ratios of (13)CO2/(12)CO2 after (+)-[(13)C]-pantoprazole relative to (13)CO2/(12)CO2 at baseline were expressed as delta over baseline (DOB). (+)-[(13)C]-pantoprazole concentrations were measured by HPLC. Genomic DNA extracted from whole blood was genotyped for CYP2C19*2, *3 and *17 using Taqman assays. Statistically significant differences in the area under the plasma concentration time curve (AUCplasma(0-∞) (p < 0.001) and oral clearance (<0.01) of (+)-[(13)C]-pantoprazole as well as in the breath test indices (delta over baseline, DOB30; and area under the DOB versus time curve, AUCDOB(0-120)) (p < 0.01) were observed among poor, intermediate and extensive metabolizer of CYP2C19. DOB30 and AUCDOB(0-120) adequately distinguished poor metabolizer from intermediate and extensive metabolizer of CYP2C19. Breath test indices significantly correlated with plasma elimination parameters of (+)-[(13)C]-pantoprazole (Pearson correlations: -0.68 to -0.73). Although relatively higher breath test indices were observed after administration of (+)-[(13)C]-pantoprazole (this study) than after (±)-[(13)C]-pantoprazole (previous study), the performance of the racemic and the enantiomer as marker of CYP2C19 activity remained similar. Our data confirm that the metabolism of (+)-[(13)C]-pantoprazole is highly dependent on CYP2C19 metabolic status, but the breath test derived from it is not superior to the racemic [(13)C]-pantoprazole in evaluating CYP2C19 activity in vivo. Thus, racemic [(13)C]-pantoprazole which is relatively easy to synthesize and more stable than (+)-[(13)C]-pantoprazole is adequate as a probe of this enzyme.
Antibodies to Borrelia burgdorferi OspA, OspC, OspF, and C6 Antigens as Markers for Early and Late Infection in Dogs (2012)

Lyme disease in the United States is caused by Borrelia burgdorferi sensu stricto, which is transmitted to mammals by infected ticks. Borrelia spirochetes differentially express immunogenic outer surface proteins (Osp). Our aim was to evaluate antibody responses to Osp antigens to aid the diagnosis of early infection and the management of Lyme disease. We analyzed antibody responses during the first 3 months after the experimental infection of dogs using a novel multiplex assay. Results were compared to those obtained with two commercial assays detecting C6 antigen. Multiplex analysis identified antibodies to OspC and C6 as early as 3 weeks postinfection (p.i.) and those to OspF by 5 weeks p.i. Antibodies to C6 and OspF increased throughout the study, while antibodies to OspC peaked between 7 and 11 weeks p.i. and declined thereafter. A short-term antibody response to OspA was observed in 3/8 experimentally infected dogs on day 21 p.i. Quant C6 enzyme-linked immunosorbent assay (ELISA) results matched multiplex results during the first 7 weeks p.i.; however, antibody levels subsequently declined by up to 29%. Immune responses then were analyzed in sera from 125 client-owned dogs and revealed high agreement between antibodies to OspF and C6 as robust markers for infection. Results from canine patient sera supported that OspC is an early infection marker and antibodies to OspC decline over time. The onset and decline of antibody responses to B. burgdorferi Osp antigens and C6 reflect their differential expression during infection. They provide valuable tools to determine the stage of infection, treatment outcomes, and vaccination status in dogs.
High-Performance Charge-Trapping Flash Memory Device With an Ultrathin 2.5-nm Equivalent- $\hbox{Si}_{3}\hbox{N}_{4}$-Thickness Trapping Layer (2011)

We made the MoN-[SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> - LaAlO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ]-[Ge-HfON]- [LaAlO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ]-Si charge-trapping (CT) Flash device with a record-thinnest 2.5-nm equivalent-Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> -thickness trapping layer, a large 4.4-V initial memory window, a 3.2-V ten-year extrapolated retention window at 125 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C, and a 3.6-V endurance window at 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cycles, under very fast 100 μs and low ±16-V program/erase pulses. These were achieved using Ge reaction with a HfON trapping layer for better CT and retention.
Wavelength division multiplexing in long-haul transmission systems (1996)

Wavelength division multiplexing shows great promise for the next generation of long-haul undersea cable transmission systems. WDM techniques will allow for greater transmission capacity and network flexibility compared to the present single-channel optical amplifier systems. The transmission of many WDM channels over transoceanic distances can be limited by a variety of phenomena, including the finite bandwidth of the erbium-doped fiber amplifier repeaters, the nonlinear interactions between channels, and the noise accumulation along the chain of amplifiers. Significant progress has been made over the past few years in understanding the nature of these impairments for long-distance transmission. This paper describes techniques used to transmit many WDM channels over transoceanic distances using the nonreturn-to-zero format and other nonsoliton methods. Data is presented for several WDM experiments including the transmission of 100 Gb/s (20 channels of 5 Gb/s) over 9100 km.
Intermetallic reinforced Cr alloys for high-temperature use (1999)

A new family of Cr(Ta)-Cr2Ta intermetallic alloys based on Cr-(6-10)Ta (at%) is currently under development for structural use in oxidizing environments in the 1,000–1,300°C temperature range. These alloys show excellent strength and creep resistance and good oxidation resistance at high temperatures in air. Oxidation resistance comparable to commercial reactive element doped chromia-forming alloys and creep resistance comparable to single-crystal superalloys have been demonstrated. To date, only modest room-temperature fracture toughness (in the 11–12 MPa m½ range) has been achieved. Preliminary results of a promising approach to improve room-temperature fracture toughness via ductilization of Cr with MgO additions are discussed.
Enzyme therapy of xeroderma pigmentosum: safety and efficacy testing of T4N5 liposome lotion containing a prokaryotic DNA repair enzyme (1996)

Xeroderma pigmentosum (XP) is a rare genetic disease in which patients are defective in DNA repair and are extremely sensitive to solar UV radiation exposure. A new treatment approach was tested in these patients, in which a prokaryotic DNA repair enzyme specific for UV-induced DNA damage was delivered into the skin by means of topically applied liposomes to supplement the deficient activity. Acute and chronic safety testing in both mice and humans showed neither adverse reactions nor significant changes in serum chemistry or in skin histology. The skin of XP patients treated with the DNA repair liposomes had fewer cyclobutylpyrimidine dimers in DNA and showed less erythema than did control sites. The results encourage further clinical testing of this new enzyme therapy approach.
Thermal luminescence spectroscopy chemical imaging sensor (2012)

The authors present a pseudo-active chemical imaging sensor model embodying irradiative transient heating, temperature nonequilibrium thermal luminescence spectroscopy, differential hyperspectral imaging, and artificial neural network technologies integrated together. We elaborate on various optimizations, simulations, and animations of the integrated sensor design and apply it to the terrestrial chemical contamination problem, where the interstitial contaminant compounds of detection interest (analytes) comprise liquid chemical warfare agents, their various derivative condensed phase compounds, and other material of a life-threatening nature. The sensor must measure and process a dynamic pattern of absorptive-emissive middle infrared molecular signature spectra of subject analytes to perform its chemical imaging and standoff detection functions successfully.
Simple, very low dark current, planar long-wavelength avalanche photodiode (1988)

We have demonstrated a novel planar, avalanche photodiode (APD) for use in long-wavelength (0.95–1.65 μm) optical communication systems. The device is a separate absorption and multiplication region APD utilizing p+ guard rings which are concentric with, but not attached to the central diffused p+-n junction region. Since no contact is made to the rings, their potential is allowed to ‘‘float’’ at a value somewhat less than that established by the externally applied voltage. The APD, which is fabricated in a manner identical to simple p-i-n photodiodes, eliminates edge breakdown effects while greatly reducing the electric field at the insulator/semiconductor interface. A 60-μm-diam junction device grown by vapor phase epitaxy is observed to have a primary dark current of &lt;300 pA, and a capacitance of 290 fF at 90% of the breakdown voltage. Uniform gains as high as 11 have been observed.
Recognition of a cervical cancer derived tumor cell line by a human papillomavirus type 16 E6 52-61-specific CD8 T cell clone. (2006)

The E6 and E7 proteins of high-risk human papillomavirus (HPV) types are thought to be the ideal sources of antigens for immunotherapy for cervical cancer since they are expressed by the tumors and not by normal cells. We recently described new HPV 16 epitopes, including the E6 52-61 peptide restricted by HLA class I molecule B57. Primary tumor cell lines were established from three HLA-B57 positive, HPV 16 positive cervical cancer patients, and their recognition by a E6 52-61 specific CD8+ T cell clone was determined using a chromium release assay and an IFN-gamma enzyme-linked immunospot (ELISPOT) assay. The recognition of homologous epitopes contained in other high-risk HPV types (18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, and 73) was also examined at the peptide level. A low level of killing of two of the tumor cell lines derived from the three patients was demonstrated using a chromium release assay. The level of killing of one of these tumor cell lines was enhanced upon treatment with IFN-gamma and/or the addition of antigen. This tumor cell line also induced measurable IFN-gamma secretion. The recognition of homologous epitopes from HPV 35, 39, 45, 51, and 73 was detected in an ELISPOT assay. Therefore, the HPV 16 E6 52-61 epitope appears to be at least weakly expressed by tumor cell lines derived from cervical cancer, and the HPV 16 E6 52-61-specific T cell clone can recognize homologous peptides derived from other high risk HPV sequences.