gebhart/patrepeval huggingface dataset:
Human fibroblast interferon in treatment of viral diseases of the skin and mucous membranes. (1983)

The therapeutic effect of human fibroblast interferon (HFIF) was studied in 33 patients. Seven had ophthalmic lesions (three due to adenovirus Type 8, four to herpes simplex virus, and one to herpes zoster) and were treated with HFIF. In the four patients with herpes simplex keratitis, HFIF was given in addition to standard therapy or together with other antiviral agents. Ten other patients, 8 with herpes simplex or herpes zoster skin or mucous membrane lesions, were treated with HFIF. HFIF was incorporated into an ointment as well as into a solution for subconjunctival infections. Although the number of cases was small, our results showed that HFIF was effective in shortening the course of the disease.
Fungal nail infection: assessing the new treatment options. (2003)

Onychomycosis can be improved or eradicated with appropriate treatment. Newer oral antifungal drugs are highly effective and have few adverse effects, although care in prescribing is needed because of potential drug interactions and hepatobiliary dysfunction.
A Bilinear Approach to the Position Self-Calibration of Multiple Sensors (2011)

This paper presents a novel algorithm for the automatic 3D localization of a set of sensors in an unknown environment. Given the measures of a set of time of arrival delays at each sensor, the approach simultaneously estimates the 3D position of the sensors and the sources that have generated the event. Such inference is obtained with no assumption about the sensor localization; the only assumption made is that the emission time of the sources must be known in order to evaluate the time of flight for each event. Moreover, we propose a further method that deals with the likely case of missing data in the measurements. This occurs when sensors are far apart or behind natural barriers that avoids the registration of the given event. Simulated experiments show the validity of the approach for different setups of sensors and number of events.
Compressed Sensing With Wavelet Domain Dependencies for Coronary MRI: A Retrospective Study (2010)

Coronary magnetic resonance imaging (MRI) is a noninvasive imaging modality for diagnosis of coronary artery disease. One of the limitations of coronary MRI is its long acquisition time due to the need of imaging with high spatial resolution and constraints on respiratory and cardiac motions. Compressed sensing (CS) has been recently utilized to accelerate image acquisition in MRI. In this paper, we develop an improved CS reconstruction method, Bayesian least squares-Gaussian scale mixture (BLS-GSM), that uses dependencies of wavelet domain coefficients to reduce the observed blurring and reconstruction artifacts in coronary MRI using traditional l(1) regularization. Images of left and right coronary MRI was acquired in 7 healthy subjects with fully-sampled k-space data. The data was retrospectively undersampled using acceleration rates of 2, 4, 6, and 8 and reconstructed using l(1) thresholding, l(1) minimization and BLS-GSM thresholding. Reconstructed right and left coronary images were compared with fully-sampled reconstructions in vessel sharpness and subjective image quality (1-4 for poor-excellent). Mean square error (MSE) was also calculated for each reconstruction. There were no significant differences between the fully sampled image score versus rate 2, 4, or 6 for BLS-GSM for both right and left coronaries (=N.S.). However, for l(1) thresholding significant differences were observed for rates higher than 2 and 4 for right and left coronaries respectively. l(1) minimization also yields images with lower scores compared to the reference for rates higher than 4 for both coronaries. These results were consistent with the quantitative vessel sharpness readings. BLS-GSM allows acceleration of coronary MRI with acceleration rates beyond what can be achieved with l(1) regularization.
19x10-GHz electro-optic ultra-flat frequency comb generation only using single conventional Mach-Zehnder modulator (2006)

We demonstrated ultra-flat optical frequency comb generation only using a set of conventional Mach-Zehnder modulator asymmetrically dual-driven by large-amplitude sinusoidal signals with different amplitudes. 19-channel 10-GHz-spaced frequency comb with ≪4.6-dB spectral ripple was experimentally generated.
Enabling the Rise of a CRISPR World (2018)

CRISPR technology has dramatically changed scientists' ability to conduct research in medicine, biotechnology, and agriculture through faster, more efficient genome editing. A key driver of the technology's adoption is the easy, fast, and inexpensive access to vectors and the resulting next-generation tools by the nonprofit plasmid repository Addgene. Since 2013, Addgene has shipped over 100,000 CRISPR plasmids to more than 75 countries worldwide. This pipeline of new technologies is enabling cutting-edge research to address the grand challenges of mankind.
A Vision and Framework for the High Altitude Platform Station (HAPS) Networks of the Future (2021)

A High Altitude Platform Station (HAPS) is a network node that operates in the stratosphere at an of altitude around 20 km and is instrumental for providing communication services. Precipitated by technological innovations in the areas of autonomous avionics, array antennas, solar panel efficiency levels, and battery energy densities, and fueled by flourishing industry ecosystems, the HAPS has emerged as an indispensable component of next-generations of wireless networks. In this article, we provide a vision and framework for the HAPS networks of the future supported by a comprehensive and state-of-the-art literature review. We highlight the unrealized potential of HAPS systems and elaborate on their unique ability to serve metropolitan areas. The latest advancements and promising technologies in the HAPS energy and payload systems are discussed. The integration of the emerging Reconfigurable Smart Surface (RSS) technology in the communications payload of HAPS systems for providing a cost-effective deployment is proposed. A detailed overview of the radio resource management in HAPS systems is presented along with synergistic physical layer techniques, including Faster-Than-Nyquist (FTN) signaling. Numerous aspects of handoff management in HAPS systems are described. The notable contributions of Artificial Intelligence (AI) in HAPS, including machine learning in the design, topology management, handoff, and resource allocation aspects are emphasized. The extensive overview of the literature we provide is crucial for substantiating our vision that depicts the expected deployment opportunities and challenges in the next 10 years (next-generation networks), as well as in the subsequent 10 years (next-next-generation networks).
Self-powered Imbibing Microfluidic Pump by Liquid Encapsulation: SIMPLE (2014)

Reliable, autonomous, internally self-powered microfluidic pumps are in critical demand for rapid point-of-care (POC) devices, integrated molecular-diagnostic platforms, and drug delivery systems. Here we report on a Self-powered Imbibing Microfluidic Pump by Liquid Encapsulation (SIMPLE), which is disposable, autonomous, easy to use and fabricate, robust, and cost efficient, as a solution for self-powered microfluidic POC devices. The imbibition pump introduces the working liquid which is sucked into a porous material (paper) upon activation. The suction of the working liquid creates a reduced pressure in the analytical channel and induces the sequential sample flow into the microfluidic circuits. It requires no external power or control and can be simply activated by a fingertip press. The flow rate can be programmed by defining the shape of utilized porous material: by using three different paper shapes with circular section angles 20°, 40° and 60°, three different volume flow rates of 0.07 μL s(-1), 0.12 μL s(-1) and 0.17 μL s(-1) are demonstrated at 200 μm × 600 μm channel cross-section. We established the SIMPLE pumping of 17 μL of sample; however, the sample volume can be increased to several hundreds of μL. To demonstrate the design, fabrication, and characterization of SIMPLE, we used a simple, robust and cheap foil-laminating fabrication technique. The SIMPLE can be integrated into hydrophilic or hydrophobic materials-based microfluidic POC devices. Since it is also applicable to large-scale manufacturing processes, we anticipate that a new chapter of a cost effective, disposable, autonomous POC diagnostic chip is addressed with this technical innovation.
Peroxisome Proliferator-activated Receptor γ Ligands Regulate Myeloperoxidase Expression in Macrophages by an Estrogen-dependent Mechanism Involving the -463GA Promoter Polymorphism (2004)

A functional myeloperoxidase (MPO) promoter polymorphism, -463GA, has been associated with incidence or severity of inflammatory diseases, including atherosclerosis and Alzheimer's disease, and some cancers. The polymorphism is within an Alu element encoding four hexamer repeats recognized by nuclear receptors (AluRRE). Here we show that peroxisome proliferator-activated receptor gamma (PPARgamma) agonists strongly regulate MPO gene expression through the AluRRE. Opposite effects were observed in granulocyte/macrophage colony-stimulating factor (GMCSF)- versus macrophage colony-stimulating factor (MCSF)-derived macrophages (Mphi): Expression was markedly up-regulated (mean 26-fold) in MCSF-Mphi and down-regulated (34-fold) in GMCSF-Mphi. This was observed with rosiglitazone and three other PPARgamma ligands of the thiazolidinedione class, as well as the natural prostaglandin metabolite 15-deoxy-Delta(12,14) prostaglandin J(2). The selective PPARgamma antagonist, GW9662, blocked both the positive and negative effects on MPO expression. Gel retardation assays showed PPARgamma bound hexamers 3/4, and estrogen receptor-alpha bound hexamers 1/2, with -463A in hexamer 1 enhancing binding. Estrogen blocked PPARgamma effects on MPO expression, especially for the A allele. Charcoal filtration of fetal calf serum eliminated the block of PPARgamma, whereas replenishing the medium with 17beta-estradiol reinstated the block. These findings suggest a model in which estrogen receptor binds the AluRRE, preventing PPARgamma binding to the adjacent site. The positive and negative regulation by PPARgamma ligands, and the block by estrogen, was also observed in transgenic mice expressing the G and A alleles. The mouse MPO gene, which lacks the primate-specific AluRRE, was unresponsive to PPARgamma ligands, suggesting the human MPO transgenes will enhance the utility of mouse models for diseases involving MPO, such as atherosclerosis and Alzheimer's.
The cost of selective recompilation and environment processing (1994)

When a single software module in a large system is modified, a potentially large number of other modules may have to be recompiled. By reducing both the number of compilations and the amount of input processed by each compilation run, the turnaround time after changes can be reduced significantly. Potential time savings are measured in a medium-sized, industrial software project over a three-year period. The results indicate that a large number of compilations caused by traditional compilation unit dependencies may be redundant. On the available data, a mechanism that compares compiler output saves about 25 percent, smart recompilation saves 50 percent, and smartest recompilation may save up to 80 percent of compilation work. Furthermore, all compilation methods other than smartest recompilation process large amounts of unused environment data. In the project analyzed, the average environment symbols are actually used. Reading only the actually used symbols would reduce total compiler input by about 50 percent. Combining smart recompilation with a reduction in environment processing might double to triple perceived compilation speed and double linker speed, without sacrificing static type safety.
Final report on the LLNL compact torus acceleration project (1995)

In this report, we summarize recent work at LLNL on the compact torus (CT) acceleration project. The CT accelerator is a novel technique for projecting plasmas to high velocities and reaching high energy density states. The accelerator exploits magnetic confinement in the CT to stably transport plasma over large distances and to directed kinetic energies large in comparison with the CT internal and magnetic energy. Applications range from heating and fueling magnetic fusion devices, generation of intense pulses of x-rays or neutrons for weapons effects and high energy-density fusion concepts.
A unified model for activity recognition from video sequences (2008)

We propose an activity recognition algorithm that utilizes a unified spatial-frequency model of motion to recognize large-scale differences in action using global statistics, and subsequently distinguishes between motions with similar global statistics by spatially localizing the moving objects. We model the Fourier transforms of translating rigid objects in a video, since the Fourier domain inherently groups regions of the video with similar motion in high energy concentrations within its domain to make global motion detectable. Frequency-domain statistics can be used to isolate the frames that both adhere to our model and contain similar global motion, thus we can separate activities into broader classes based on their global motion. A least-squares solution is then solved to isolate the spatially discriminative object configurations that produce similar global motion statistics. This model provides a unified framework to form concise globally-optimal spatial and motion descriptors necessary for discriminating activities. Experimental results are demonstrated on a human activity dataset.
Strategies for the Use of Data and Algorithm Approaches in Railway Traffic Management (2021)

Resonate are interested in looking at different strategies / models / techniques for dealing with the problem of rescheduling a railway timetable when it's unexpectedly disrupted, the likely strengths and risks of these, and how they might be adapted to improve existing solutions. Nine different approaches (drawn from machine learning, network models and stochastic models) to defining the efficiency of a station in dissipating delays were considered. They fell broadly into two groups: those that sought to understand the propagation of delays and those that sought to offer strategies for minimising delays.
Video coding for streaming media delivery on the Internet (2001)

We provide an overview of an architecture of today's Internet streaming media delivery networks and describe various problems that such systems pose with regard to video coding. We demonstrate that based on the distribution model (live or on-demand), the type of the network delivery mechanism (unicast versus multicast), and optimization criteria associated with particular segments of the network (e.g., minimization of distortion for a given connection rate, minimization of traffic in the dedicated delivery network, etc.), it is possible to identify several models of communication that may require different treatment from both source and channel coding perspectives. We explain how some of these problems can be addressed using a conventional framework of temporal motion-compensated, transform-based video compression algorithm, supported by appropriate channel-adaptation mechanisms in client and server components of a streaming media system. Most of these techniques have already been implemented in RealNetworks(R) RealSystem(R) 8 and its RealVideo(R) 8 codec, which we use throughout the paper to illustrate our results.
Silicon integration of digital user-end mobile communication systems (2002)

An approach to single-chip integration of digital user-end mobile communication systems is presented. The characteristics of this class of DSP (digital signal processing) systems define the requirements of the proposed system architecture and system design environment. A distributed control approach has been chosen. The system design environment provides high-level system synthesis towards mixed architectural styles and silicon assembly in mixed layout styles, in order to reach a solution with optimal area and power usage. The concept is demonstrated with the single-chip realization of the baseband part of a mobile terminal transmitter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Convenient synthetic route to 6,8-dioxabicyclo[3.2.1]octanes, the aggregation pheromone components of bark beetles (1983)

Convenient syntheses of (±)-frontalin (I) and (±)-brevicomins (IIa) and (IIb) were achieved from pent-4-en-1-ol (2) and pent-4-yn-1-ol (3). In a few simple and unambiguous steps, the alkenol (2) and the alkynol (3) were transformed into the acetal bromide (7) and the alkenyl bromides (14) and (17), respectively. Acylation of the Grignard reagents of these bromides provided the corresponding methyl ketones (8), (15), and (18), the key intermediates for the synthesis of the title bicyclic acetals. The ketone (8) was converted into the olefin (9) which, on epoxidation followed by acid hydrolysis, yielded (±)-frontalin, whereas epoxidation of the alkenones (15) and (18) and subsequent cyclisation afforded exo-and endo-brevicomin, stereoselectively.
AraC Regulatory Protein Mutants with Altered Effector Specificity (2008)

The AraC regulatory protein of the Escherichia coli ara operon has been engineered to activate transcription in response to D-arabinose and not in response to its native effector L-arabinose. Two different AraC mutant libraries, each with four randomized binding pocket residues, were subjected to FACS-mediated dual screening using a GFP reporter. Both libraries yielded mutants with the desired switch in effector specificity, and one mutant we describe maintains tight repression in the absence of effector. The presence of 100 mM L-arabinose does not influence the response of the reported mutants to D-arabinose, and the mutants are not induced by other sugars tested (D-xylose, D-fucose, D-lyxose). Co-expression of the FucP transporter in E. coli enabled induction by D-arabinose in the 0.1 mM range. Our results demonstrate the power of dual screening for altering AraC inducer specificity and represent steps toward the design of customized in vivo molecular reporters and gene switches for metabolic engineering.
Pulmonary Embolism Detection with Dual-Energy CT: Experimental Study of Dual-Source CT in Rabbits (2009)

Dual-source CT can depict normal and abnormal blood perfusion distribution in a rabbit's lung. Abnormal pulmonary blood distribution, as shown at dual-source CT, improves detection of acute PE in rabbits.
On the accuracy of a Stewart platform. II. Kinematic calibration and compensation (2002)

An effective algorithm for the identification of the kinematic parameters of a Stewart platform is presented and verified through simulations. The algorithm can be applied to both the reduced and the full models, which differ by the number of parameters to be identified. Compensation procedures for models are also presented. The algorithm was tested using simulated measurements that included realistic measurement noise, and the results showed that the platform pose error was reduced by at least one order of magnitude. The identification algorithm is computationally expensive and has to be performed on a powerful computer for practical implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Perceptual and Physiological Responses to Carbohydrate and Menthol Mouth-Swilling Solutions: A Repeated Measures Cross-Over Preliminary Trial (2021)

Carbohydrate and menthol mouth-swilling have been used to enhance exercise performance in the heat. However, these strategies differ in mechanism and subjective experience. Participants (n = 12) sat for 60 min in hot conditions (35 °C; 15 ± 2%) following a 15 min control period, during which the participants undertook three 15 min testing blocks. A randomised swill (carbohydrate; menthol; water) was administered per testing block (one swill every three minutes within each block). Heart rate, tympanic temperature, thermal comfort, thermal sensation and thirst were recorded every three minutes. Data were analysed by ANOVA, with carbohydrate intake controlled for via ANCOVA. Small elevations in heart rate were observed after carbohydrate (ES: 0.22 ± 90% CI: −0.09–0.52) and water swilling (0.26; −0.04–0.54). Menthol showed small improvements in thermal comfort relative to carbohydrate (−0.33; −0.63–0.03) and water (−0.40; from −0.70 to −0.10), and induced moderate reductions in thermal sensation (−0.71; from −1.01 to −0.40 and −0.66; from −0.97 to −0.35, respectively). Menthol reduced thirst by a small to moderate extent. These effects persisted when controlling for dietary carbohydrate intake. Carbohydrate and water may elevate heart rate, whereas menthol elicits small improvements in thermal comfort, moderately improves thermal sensation and may mitigate thirst; these effects persist when dietary carbohydrate intake is controlled for.
Learning to recognize human action sequences (2003)

One of the major sources of cues in developmental learning is that of watching another person. An observer can gain a comprehensive description of the purposes of actions by watching the other person's detailed bode, movements. Action recognition has traditionally studied processing fixed camera observations while ignoring nonvisual information. This paper explores the dynamic properties of eye movements in natural tasks: eye and head movements are quite tightly coupled with actions. We present a method that utilizes eye gaze and head position information to detect the performer's focus of attention. Attention, as represented by eye fixation, is used for spotting the target object related to the action. Attention switches are calculated and used to segment the action sequence into action units which are recognized by hidden Markov models. An experimental system is built for recognizing actions in the natural task of "stapling a letter", which demonstrates the effectiveness of the approach.
Bromocriptine for Cocaine Dependence (1997)

On the basis of the dopamine depletion theory, bromocriptine has been tested to treat cocaine withdrawal and dependence. The authors conducted a 6‐week study with 1 week of pretreatment observation and 5 weeks of a randomized, double‐blind, placebo‐controlled clinical trial of bromocriptine for DSM‐III‐R‐defined cocaine dependence in methadone‐maintained male patients. The bromocriptine group ( n = 24) did not differ from the placebo group ( n = 26) in self‐reported cocaine use, proportion of positive urine toxicology samples, craving for cocaine, resistance to cocaine use, or mood symptoms between the pretreatment baseline and the last week of the clinical trial. Both groups showed significant reduction in self‐reported frequency of cocaine use, resistance to craving, and mood symptoms during participation in the protocol. The results of this study are consistent with recent clinical and laboratory findings in primary cocaine users. Despite initially promising pilot studies, recent evidence does not support the efficacy of bromocriptine to reduce cocaine use or craving.
Trustworthy Execution on Mobile Devices: What security properties can my mobile platform give me? (CMU-CyLab-11-023) (2018)

We are now in the post-PC era, yet our mobile devices are insecure. We consider the different stake-holders in today’s mobile device ecosystem, and analyze why widely-deployed hardware security primitives on mobile device platforms are inaccessible to application developers and end-users. We systematize existing proposals for leveraging such primitives, and show that they can indeed strengthen the security properties available to applications and users, all without reducing the properties currently enjoyed by OEMs and network carriers. We also highlight shortcomings of existing proposals and make recommendations for future research that may yield practical, deployable results.