gebhart/patrepeval huggingface dataset:
Source and Listener Directivity for Interactive Wave-Based Sound Propagation (2014)

We present an approach to model dynamic, data-driven source and listener directivity for interactive wave-based sound propagation in virtual environments and computer games. Our directional source representation is expressed as a linear combination of elementary spherical harmonic (SH) sources. In the preprocessing stage, we precompute and encode the propagated sound fields due to each SH source. At runtime, we perform the SH decomposition of the varying source directivity interactively and compute the total sound field at the listener position as a weighted sum of precomputed SH sound fields. We propose a novel plane-wave decomposition approach based on higher-order derivatives of the sound field that enables dynamic HRTF-based listener directivity at runtime. We provide a generic framework to incorporate our source and listener directivity in any offline or online frequency-domain wave-based sound propagation algorithm. We have integrated our sound propagation system in Valve's Source game engine and use it to demonstrate realistic acoustic effects such as sound amplification, diffraction low-passing, scattering, localization, externalization, and spatial sound, generated by wave-based propagation of directional sources and listener in complex scenarios. We also present results from our preliminary user study.
Three dimensional moving pictures with a single imager and microfluidic lens (2014)

Three-dimensional movie acquisition and corresponding depth data is commonly generated from multiple cameras and multiple views. This technology has high cost and large size which are limitations for current consumer products, such as small camcorders and cell phone movie cameras. This research result shows that a single imager, equipped with a fast-focus microfluidic lens, produces a highly accurate depth map. On test material, the depth is found to be an average Root Mean Squared Error (RMSE) of 4.67 gray level steps (1.8%) accuracy compared to ranging data. The depth is inferred using a new Extended Depth from Defocus (EDfD), and defocus is achieved at movie speeds with a microfluidic lens. In addition, early indications show that real-time HDTV 3D movie frame rates are feasible.
Preparation of protein concentrate from pearl millet (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of protein concentrate from pearl milletAugust V. Bailey and Gene SumrellCite this: J. Agric. Food Chem. 1980, 28, 2, 475–477Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/jf60228a049https://doi.org/10.1021/jf60228a049research-articleACS PublicationsRequest reuse permissionsArticle Views151Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Approaches to the synthesis of a novel, anti-HIV active integrase inhibitor (2013)

The novel HIV-1 integrase inhibitor 1, discovered in our laboratory, exhibits potent anti-HIV activity against a diverse set of HIV-1 isolates and also against HIV-2 and SIV. In addition, this compound displays low cellular cytotoxicity and possesses a favorable in vitro drug interaction profile with respect to isozymes of cytochrome P450 (CYP) and uridine 5'-diphospho-glucuronosyltransferase (UGT). However, the total synthesis of this significant HIV integrase inhibitor has not been reported. This contribution describes an optimized, reproducible, multi-step, synthetic route to inhibitor 1. The yield for the separate steps averaged about 80%. The methodologies utilized in the synthesis were, among others, a palladium-catalyzed cross-coupling reaction, a crossed-Claisen condensation, and a hydrazino amide synthesis step. Successful alternative synthetic methodologies for some of the steps are also described.
Interference avoidance in 3GPP femtocell networks using resource partitioning and sensing (2010)

Interference problems in cochannel femtocell networks may cause significant performance degradation for certain femtocell/macrocell users. These problems and potential solutions are recently being investigated within the 3GPP. The goal of the present paper is to review the simulation framework for femtocell networks in 3GPP and briefly summarize some of the important inter-cell interference coordination (ICIC) techniques that have been discussed. Then, a new intercell interference avoidance (ICIA) method is proposed for femtocell networks which is based on resource partitioning and sensing. Different than prior art techniques, the proposed approach does not require the use of X2 interface or over-the air signaling, both of which may be infeasible/costly for femtocells with the available releases of the 3GPP.
Highly sensitive and specific novel biomarkers for the diagnosis of transitional bladder carcinoma (2015)

Transitional bladder carcinoma (BCa) is prevalent in developed countries, particularly among men. Given that these tumors frequently recur or progress, the early detection and subsequent monitoring of BCa at different stages is critical. Current BCa diagnostic biomarkers are not sufficiently sensitive for substituting or complementing invasive cystoscopy. Here, we sought to identify a robust set of urine biomarkers for BCa detection. Using a high-resolution, mass spectrometry-based, quantitative proteomics approach, we measured, compared and validated protein variations in 451 voided urine samples from healthy subjects, non-bladder cancer patients and patients with non-invasive and invasive BCa. We identified five robust biomarkers: Coronin-1A, Apolipoprotein A4, Semenogelin-2, Gamma synuclein and DJ-1/PARK7. In diagnosing Ta/T1 BCa, these biomarkers achieved an AUC of 0.92 and 0.98, respectively, using ELISA and western blot data (sensitivity, 79.2% and 93.9%; specificity, 100% and 96.7%, respectively). In diagnosing T2/T3 BCa, an AUC of 0.94 and 1.0 was attained (sensitivity, 86.4% and 100%; specificity, 100%) using the same methods. Thus, our multiplex biomarker panel offers unprecedented accuracy for the diagnosis of BCa patients and provides the prospect for a non-invasive way to detect bladder cancer.
P‐167: 4.5″ Electrochromic Display with Passive Matrix Driving (2008)

Abstract 4.5″ electrochromic (EC) display has been fabricated and driven by passive matrix (PM) driving method. The ‘cross‐talk’ problem between cell units, induced easily by PM driving skill, has been solved using gel type electrolyte and its isolation. White reflector makes good white reflectance, of which value is above 60%. The simple structure and easy driving method allow the device application in various areas, such as simple segment driving devices, display information (DI) board, and paper like display (PLD).
Parameterizing cell-to-cell regulatory heterogeneities via stochastic transcriptional profiles (2014)

Regulated changes in gene expression underlie many biological processes, but globally profiling cell-to-cell variations in transcriptional regulation is problematic when measuring single cells. Transcriptome-wide identification of regulatory heterogeneities can be robustly achieved by randomly collecting small numbers of cells followed by statistical analysis. However, this stochastic-profiling approach blurs out the expression states of the individual cells in each pooled sample. Here, we show that the underlying distribution of single-cell regulatory states can be deconvolved from stochastic-profiling data through maximum-likelihood inference. Guided by the mechanisms of transcriptional regulation, we formulated plausible mixture models for cell-to-cell regulatory heterogeneity and maximized the resulting likelihood functions to infer model parameters. Inferences were validated both computationally and experimentally for different mixture models, which included regulatory states for multicellular function that were occupied by as few as 1 in 40 cells of the population. Importantly, when the method was extended to programs of heterogeneously coexpressed transcripts, we found that population-level inferences were much more accurate with pooled samples than with one-cell samples when the extent of sampling was limited. Our deconvolution method provides a means to quantify the heterogeneous regulation of molecular states efficiently and gain a deeper understanding of the heterogeneous execution of cell decisions.
Regulation of Androgen Action by Receptor Gene Inhibitiona (1995)

Regulated functions of hormonal agents play a critical role in health and disease. Target cell responsiveness to a hormonal signal is a product of both cellular concentrations of the hormone ligand and the corresponding receptor protein. The major thrust of the drug design for treatment of endocrine-related problems, so far, has been directed to ligand derivatives. In certain cases, receptor regulation through antigene technology has much to offer with improvements in both target cell and hormonal specificity. Three different antigene approaches are currently being explored. The first approach is to inhibit the expression of the receptor gene by disrupting the DNA protein interaction at critical cis-elements by short triple helix-forming oligonucleotides. The second approach is to sequester and inactivate the receptor mRNA by the antisense mRNA produced in the target tissue directed by a heterologous tissue-specific promoter. The third approach is the tissue-specific expression of a catalytic ribozyme that binds to the specific receptor mRNA and selectively degrades it before its translation into the protein. In this study, we have characterized the promoter of the rat androgen receptor, and by progressive deletion from its 5' end have identified two critical cis-regulatory elements, one at the -960 to -940 region and the other at the -554 to -574 positions. The former is an activator while the latter is an inhibitor domain. The inhibitory domain is the binding site for the nuclear factor kappa B (NF-kappa B) and more specifically, the p50/p50 homodimer of this transcription factor family. We have also provided correlative data to show that under normal physiological conditions, the NF-kappa B functions as an antiandrogen during the age-dependent desensitization of the liver. In addition to the naturally functioning antiandrogenic influence of NF-kappa B, we have designed an artificial antiandrogenic agent, a triplex-forming oligonucleotide (TFO) directed to the -960/-940 activator domain of the rat androgen receptor gene promoter. This oligonucleotide at a TFO-to-promoter ratio of 500 is able to cause about 60% inhibition of rAR promoter function in transfected COS-1 cells. These results clearly demonstrate the feasibility of the antigene approach for effective inhibition of steroid hormone action.
A fast algorithm for feature selection in conditional maximum entropy modeling (2003)

This paper describes a fast algorithm that selects features for conditional maximum entropy modeling. Berger et al. (1996) presents an incremental feature selection (IFS) algorithm, which computes the approximate gains for all candidate features at each selection stage, and is very time-consuming for any problems with large feature spaces. In this new algorithm, instead, we only compute the approximate gains for the top-ranked features based on the models obtained from previous stages. Experiments on WSJ data in Penn Treebank are conducted to show that the new algorithm greatly speeds up the feature selection process while maintaining the same quality of selected features. One variant of this new algorithm with look-ahead functionality is also tested to further confirm the good quality of the selected features. The new algorithm is easy to implement, and given a feature space of size F, it only uses O(F) more space than the original IFS algorithm.
Avatar digitization from a single image for real-time rendering (2017)

We present a fully automatic framework that digitizes a complete 3D head with hair from a single unconstrained image. Our system offers a practical and consumer-friendly end-to-end solution for avatar personalization in gaming and social VR applications. The reconstructed models include secondary components (eyes, teeth, tongue, and gums) and provide animation-friendly blendshapes and joint-based rigs. While the generated face is a high-quality textured mesh, we propose a versatile and efficient polygonal strips (polystrips) representation for the hair. Polystrips are suitable for an extremely wide range of hairstyles and textures and are compatible with existing game engines for real-time rendering. In addition to integrating state-of-the-art advances in facial shape modeling and appearance inference, we propose a novel single-view hair generation pipeline, based on 3D-model and texture retrieval, shape refinement, and polystrip patching optimization. The performance of our hairstyle retrieval is enhanced using a deep convolutional neural network for semantic hair attribute classification. Our generated models are visually comparable to state-of-the-art game characters designed by professional artists. For real-time settings, we demonstrate the flexibility of polystrips in handling hairstyle variations, as opposed to conventional strand-based representations. We further show the effectiveness of our approach on a large number of images taken in the wild, and how compelling avatars can be easily created by anyone.
Airflow and Particle Velocities Near a Personal Aerosol Sampler with a Curved, Porous Aerosol Sampling Surface (1998)

ABSTRACT The airflow and particle-velocity patterns in the vicinity of a curved, porous sampling surface constituting the inlet of an aerosol sampler, have been determined by Laser-Doppler Velocimetry. The tests were performed on a personal aerosol sampler with a concave sampling surface, referred to as the “button” sampler. Measurements with the button sampler were conducted in a low-speed, open-circuit, horizontal wind tunnel using two types of monodisperse aerosols: 2 μm essentially inertialess propylene glycol particles (their trajectories represent the flow streamlines) and 44 μm inertial fly ash particles. The tests were performed at two free stream velocities (0.5 and 4 m/s) and two sampler orientations (facing the wind and facing downward at 90° to the wind). The sampling flow rate was 2 L/min. Sampling through the curved surface was conducted while the button sampler was freely suspended in the flow or while it was attached to a vertical stagnation plate simulating the human torso. The results indicated that the nondimensionalized airflow patterns and particle-velocity fields near the curved inlet surface were similar at different wind velocities, as long as the button sampler faced the wind. When a stagnation plate was added, while facing the wind, the airflow patterns and particle trajectories were not significantly affected. Based on limiting streamline considerations, it was concluded that only a small part of the incoming flow was aspired into the inlet. This limited transparency of the inlet to the incoming airflow caused the deflection of the airflow along the curved surface and explained the low dependence of the airflow patterns on the magnitude of the free stream velocity when the curved inlet surface faced the wind. However, the effects of wind velocity and plate on the airflow and particle velocity became significant when the inlet orientation was changed to 90° to the wind. This suggests that a curved, porous surface is beneficial as an aerosol sampling inlet when the wind direction is perpendicular or close to perpendicular to the surface. However, this benefit is reduced or eliminated when sampling at 90° to the wind.
EVPN Optimized Inter-Subnet Multicast (OISM) Forwarding (2024)

Ethernet VPN (EVPN) provides a service that allows a single Local Area
Network (LAN), comprising a single IP subnet, to be divided into
multiple segments. Each segment may be located at a different site,
and the segments are interconnected by an IP or MPLS backbone. Intra-
subnet traffic (either unicast or multicast) always appears to the
endusers to be bridged, even when it is actually carried over the IP
or MPLS backbone. When a single tenant owns multiple such LANs, EVPN
also allows IP unicast traffic to be routed between those LANs. This
document specifies new procedures that allow inter-subnet IP multicast
traffic to be routed among the LANs of a given tenant, while still
making intra-subnet IP multicast traffic appear to be bridged. These
procedures can provide optimal routing of the inter- subnet multicast
traffic, and do not require any such traffic to leave a given router
and then reenter that same router. These procedures also accommodate
IP multicast traffic that needs to travel to or from systems that are
outside the EVPN domain.
Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling (2017)

Angiogenesis is central to both normal and pathologic processes. Endothelial cells (ECs) express O-glycoproteins that are believed to play important roles in vascular development and stability. Endomucin-1 (EMCN) is a type I O-glycosylated, sialic-rich glycoprotein, specifically expressed by venous and capillary endothelium. Evidence has pointed to a potential role for EMCN in angiogenesis but it had not been directly investigated. In this study, we examined the role of EMCN in angiogenesis by modulating EMCN levels both in vivo and in vitro. Reduction of EMCN in vivo led to the impairment of angiogenesis during normal retinal development in vivo. To determine the cellular basis of this inhibition, gain- and loss-of-function studies were performed in human retinal EC (HREC) in vitro by EMCN over-expression using adenovirus or EMCN gene knockdown by siRNA. We show that EMCN knockdown reduced migration, inhibited cell growth without compromising cell survival, and suppressed tube morphogenesis of ECs, whereas over-expression of EMCN led to increased migration, proliferation and tube formation. Furthermore, knockdown of EMCN suppressed VEGF-induced signaling as measured by decreased phospho-VEGFR2, phospho-ERK1/2 and phospho-p38-MAPK levels. These results suggest a novel role for EMCN as a potent regulator of angiogenesis and point to its potential as a new therapeutic target for angiogenesis-related diseases.
New Alkoxyamines from the Addition of Free Radicals to Nitrones or Nitroso Compounds as Initiators for Living Free Radical Polymerization (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTNew Alkoxyamines from the Addition of Free Radicals to Nitrones or Nitroso Compounds as Initiators for Living Free Radical Polymerization 1Marie-Odile Zink, Andreas Kramer, and Peter NesvadbaView Author Information Ciba Specialty Chemicals Inc., CH-4002 Basle, Switzerland Cite this: Macromolecules 2000, 33, 21, 8106–8108Publication Date (Web):September 19, 2000Publication History Received26 April 2000Revised19 July 2000Published online19 September 2000Published inissue 1 October 2000https://pubs.acs.org/doi/10.1021/ma000732bhttps://doi.org/10.1021/ma000732bbrief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views548Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Free radicals,Living polymerization,Organic compounds,Polymerization,Styrenes Get e-Alerts
Fitting of calibration-free scanned-wavelength-modulation spectroscopy spectra for determination of gas properties and absorption lineshapes (2014)

The development and initial demonstration of a scanned-wavelength, first-harmonic-normalized, wavelength-modulation spectroscopy with nf detection (scanned-WMS-nf/1f) strategy for calibration-free measurements of gas conditions are presented. In this technique, the nominal wavelength of a modulated tunable diode laser (TDL) is scanned over an absorption transition to measure the corresponding scanned-WMS-nf/1f spectrum. Gas conditions are then inferred from least-squares fitting the simulated scanned-WMS-nf/1f spectrum to the measured scanned-WMS-nf/1f spectrum, in a manner that is analogous to widely used scanned-wavelength direct-absorption techniques. This scanned-WMS-nf/1f technique does not require prior knowledge of the transition linewidth for determination of gas properties. Furthermore, this technique can be used with any higher harmonic (i.e., n>1), modulation depth, and optical depth. Selection of the laser modulation index to maximize both signal strength and sensitivity to spectroscopic parameters (i.e., gas conditions), while mitigating distortion, is described. Last, this technique is demonstrated with two-color measurements in a well-characterized supersonic flow within the Stanford Expansion Tube. In this demonstration, two frequency-multiplexed telecommunication-grade TDLs near 1.4 μm were scanned at 12.5 kHz (i.e., measurement repetition rate of 25 kHz) and modulated at 637.5 and 825 kHz to determine the gas temperature, pressure, H2O mole fraction, velocity, and absorption transition lineshape. Measurements are shown to agree within uncertainty (1%-5%) of expected values.