gebhart/patrepeval huggingface dataset:
Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: Precursors of noncatecholaminergic enteric neurons (1990)

Experiments were done to study the fate of transient catecholaminergic (TC) cells that develop in the rodent gut during ontogeny. When they are first detected, at Day E11 in rats, TC cells are distributed along the vagal pathway, in advance of the descending fibers of the vagus nerves, and in the foregut. The early TC cells coexpress the immunoreactivities of several neural markers, including 150-kDa neurofilament protein, peripherin, microtubule associated protein (MAP) 5, and growth-associated protein (GAP)-43, with those of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH). All cells in the fetal rat bowel at Day E11 that express neural markers also express TH immunoreactivity. The primitive TC cells also express the immunoreactivities of neural cell adhesion molecule (N-CAM), neuropeptide Y (NPY), and nerve growth factor (NGF) receptor (and NGF receptor mRNA). By Day E12 TC cells are found along the vagal pathway and throughout the entire preumbilical bowel. At this age TC cells acquire additional characteristics, including MAP 2 and synaptophysin immunoreactivities and acetylcholinesterase activity, which indicate that they continue to mature as neurons. In addition, TC cells of the rat are immunostained at Day E12 by the NC-1 monoclonal antibody, which in rats labels multiple cell types including migrating cells of neural crest origin. Despite their neural properties, at least some TC cells divide and therefore are neural precursors and not terminally differentiated neurons. At Day E10 TH mRNA-containing cells were not detected by in situ hybridization; however, by Day E11 TH mRNA was detected in sympathetic ganglia and in scattered cells in the mesenchyme of the foregut and vagal pathway. At this age, the number of enteric and vagal cells containing TH mRNA is about 30% less than the number of cells containing TH immunoreactivity in adjacent sections. The ratio of TH mRNA-containing cells to TH-immunoreactive vagal and enteric cells is even less at Day E12, especially in more caudal regions of the preumbilical bowel. A similar decline in the ratio of TH mRNA-containing to TH-immunoreactive cells was not observed in sympathetic ganglia. After Day E12 TH mRNA cannot be detected in enteric or vagal cells by in situ hybridization; nevertheless, TH immunoreactivity continues to be present through Day E14. DBH, NPY, and NGF receptor immunoreactivities are expressed by TH-immunoreactive transitional cells in the fetal rat gut after TH mRNA is no longer detectable.(ABSTRACT TRUNCATED AT 400 WORDS)
A 4.5 &#x03BC;W 2.4 GHz wake-up receiver based on complementary current-reuse RF detector (2015)

This paper presents an ultra-low-power wake-up receiver (WuRx) for use in the worldwide recognized 2.4 GHz ISM band. The WuRx features a fully-differential complementary current-reuse RF detector with an embedded impedance matching network. The proposed WuRx does not require power-hungry RF amplification and frequency down-conversion circuits, so the power consumption can be significantly reduced. The measurement results show that the proposed receiver achieves a sensitivity of -50 dBm and has a power consumption of just 4.5 μW in a 0.18-μm CMOS technology. Consequently, it provides a promising solution for a wide range of low-power wireless sensor network and wireless body area network applications.
Concurrent Conditions and Human Listeriosis, England, 1999–2009 (2010)

The epidemiology of listeriosis in England and Wales changed during 2001-2008; more patients ≥60 years of age had bacteremia than in previous years. To investigate these changes, we calculated risk for listeriosis by concurrent condition for non-pregnancy-associated listeriosis cases reported to the national surveillance system in England during 1999-2009. Conditions occurring with L. monocytogenes infection were coded according to the International Classification of Diseases, 10th Revision, and compared with appropriate hospital episode statistics inpatient denominator data to calculate incidence rates/million consultations. Malignancies (especially of the blood), kidney disease, liver disease, diabetes, alcoholism, and age ≥60 years were associated with an increased risk for listeriosis. Physicians should consider a diagnosis of listeriosis when treating patients who have concurrent conditions. Providing cancer patients, who accounted for one third of cases, with food safety information might help limit additional cases.
A High Isolation and High Selectivity Ladder-Lattice BAW-SMR Filter (2006)

This paper presents a BAW-SMR filter using a combined ladder-lattice topology for application in W-CDMA reception front-ends (2.11 - 2.17 GHz). The combined topology allies the advantages of both network types, having very steep responses and high isolation at undesired bands. The design of filter was simulated using a combined 2D EM-acoustical analysis procedure, it presents: 1.6 dB of insertion loss, -10 dB of return loss and isolation higher than -48 dB at TX band (1.92 - 1.98 GHz)
Measurement of spatial cross sections of ultrasound pressure fields by optical scanning means (2005)

The measurement of spatial cross sections of ultrasound pressure fields is an essential element of exposimetry of ultrasonic medical equipment. An optical technique is presented that allows the two-dimensional (2-D) determination of ultrasound pressure using an optical multilayer hydrophone in which a laser beam with suitable wavelength is partially reflected from a dielectric optical multilayer system. By detecting the change in reflectivity of the multilayer coating induced by the incident ultrasound, the pressure time waveform can be determined. A 2-D data acquisition covering an area of at least 15 mm x 5 mm was realized by two complementary approaches. A serial detection scheme was set up by scanning the sensing point across the area of interest by a micromechanically engineered scanning mirror and acquiring pressure time waveforms sequentially and pointwise. This allows the measurement of repeating ultrasonic waveforms with a spatial resolution of better than 70 microm and a minimal detectable pressure of 50 kPa (bandwidth: 50 MHz) in a few seconds. In an alternative approach exploiting the parallel processing capabilities of a charge-coupled devices (CCD) camera chip, the probe was strobe-illuminated by a large-diameter collimated beam of a pulsed laser diode. The 2-D pressure distribution at a particular moment was derived from captured reflectivity distributions with a spatial resolution of 75 microm. By successive delaying of the laser pulse with respect to the ultrasound pulse, the complete 2-D pulse waveform was acquired with high spatial resolution. Measurement results on ultrasound fields from plane and focusing transducers are presented and compared to simulation results. Individual advantages and drawbacks of both approaches are discussed. A combined setup merging both detection schemes into a single device was developed and represents a milestone on the way toward constructing an optical ultrasound measuring camera.
cDNA sequence of the human atrial natriuretic peptide clearance receptor (1990)

Journal Article cDNA sequence of the human atrial natriuretic peptide clearance receptor Get access David G. Lowe, David G. Lowe Department of Molecular Biology, Genentech Inc., 460 Point San Bruno BoulevardSouth San Francisco, CA 94080, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas R. Camerato, Thomas R. Camerato Department of Molecular Biology, Genentech Inc., 460 Point San Bruno BoulevardSouth San Francisco, CA 94080, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar David V. Goeddle David V. Goeddle Department of Molecular Biology, Genentech Inc., 460 Point San Bruno BoulevardSouth San Francisco, CA 94080, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 11, 11 June 1990, Page 3412, https://doi.org/10.1093/nar/18.11.3412 Published: 11 June 1990 Article history Received: 03 April 1990 Published: 11 June 1990
RNA virus microRNA that mimics a B-cell oncomiR (2012)

MicroRNAs (miRNAs) are small RNAs that play a regulatory role in numerous and diverse eukaryotic cellular processes. Virus-encoded miRNAs have garnered much interest, although the functions of most remain to be deciphered. To date, readily detectable, evolutionarily conserved natural miRNAs have only been identified from viruses with DNA genomes. Combined with the fact that most miRNAs are generated from endonucleolytic cleavage of longer transcripts, this finding has led to a common conception that naturally occurring RNA viruses will not encode miRNAs to avoid unproductive cleavage of their genomes or mRNAs. Here we demonstrate that the bovine leukemia virus (BLV), a retrovirus with an RNA genome, encodes a conserved cluster of miRNAs that are transcribed by RNA polymerase III (pol III). Thus, the BLV miRNAs avoid the conundrum of genome/mRNA cleavage because only the subgenomic pol III transcripts are efficiently processed into miRNAs. BLV infection is strongly associated with B-cell tumors in cattle. Because most cells in BLV-associated tumors express little viral mRNAs or proteins, exactly how BLV contributes to tumorigenesis has remained a decades-long unsolved mystery. One BLV miRNA, BLV-miR-B4, shares partial sequence identity and shared common targets with the host miRNA, miR-29. As miR-29 overexpression is associated with B-cell neoplasms that resemble BLV-associated tumors, our findings suggest a possible mechanism contributing to BLV-induced tumorigenesis.
SARS-CoV-2 Variants Detection Using TaqMan SARS-CoV-2 Mutation Panel Molecular Genotyping Assays (2021)

Our study indicates that TaqMan SARS-CoV-2 mutation panel molecular genotyping assays detect and differentiate all published common variants B.1.617.2 (Delta), B.1.1.7 (Alpha), B.1.526 (Iota), B.1.351 (Beta), P.1 (Gamma), P.2 (Zeta), B.1.617.1 (Kappa) and B.1.427/B.1.429 (Epsilon) that can be used for surveillance and epidemic control and prevention.
3,4-Methylenedioxymethamphetamine facilitates fear extinction learning (2015)

Acutely administered 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') has been proposed to have long-term positive effects on post-traumatic stress disorder (PTSD) symptoms when combined with psychotherapy. No preclinical data support a mechanistic basis for these claims. Given the persistent nature of psychotherapeutic gains facilitated by MDMA, we hypothesized that MDMA improves fear extinction learning, a key process in exposure-based therapies for PTSD. In these experiments, mice were first exposed to cued fear conditioning and treated with drug vehicle or MDMA before extinction training 2 days later. MDMA was administered systemically and also directly targeted to brain structures known to contribute to extinction. In addition to behavioral measures of extinction, changes in mRNA levels of brain-derived neurotrophic factor (Bdnf) and Fos were measured after MDMA treatment and extinction. MDMA (7.8 mg kg(-1)) persistently and robustly enhanced long-term extinction when administered before extinction training. MDMA increased the expression of Fos in the amygdala and medial prefrontal cortex (mPFC), whereas increases in Bdnf expression were observed only in the amygdala after extinction training. Extinction enhancements were recapitulated when MDMA (1 μg) was infused directly into the basolateral complex of the amygdala (BLA), and enhancement was abolished when BDNF signaling was inhibited before extinction. These findings suggest that MDMA enhances fear memory extinction through a BDNF-dependent mechanism, and that MDMA may be a useful adjunct to exposure-based therapies for PTSD and other anxiety disorders characterized by altered fear learning.
Orthogonal Interpolation Method for Order Reduction of a Synchronous Machine Model (2017)

This paper introduces an interpolation method based on snapshot approach to reduce the order of a nonlinear model for magnetostatic problems and facilitate the evaluation of the corresponding system of equations. The solution of the reduced model for a set of given inputs is built by interpolating the right singular vectors, obtained from singular value decomposition of snapshots. To validate the efficiency of this method, this reduced model is compared with full-order finite-element model. Furthermore, the proposed method is analyzed with respect to a more conventional model order reduction that is combined with the discrete empirical interpolation method. The orthogonal interpolation method is the most effective method to reduce model of an interior permanent magnet synchronous machine especially in term of computational time.
A Novel and Direct Method for the Preparation of 4‐Amino‐1,1,3,3‐tetrasubstituted Guanidines and of [1,2,4]Triazolo‐Fused Heterocyclic Derivatives. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Performance enhancement of multistage interconnection networks with unit step buffering (1999)

Multistage interconnection networks (MINs) have been widely used for parallel computer systems, and also recognized as an efficient switching fabric for digital communication. In this paper, we propose a new switching mechanism for MINs called unit step buffering (USB) which significantly improves the network performance. Here each cell is allowed to move only one buffer entry position using short network cycle. The proposed USB scheme is compared to the traditional scheme by analytical modeling and computer simulation. They reveal that throughput and delay are improved about 60%-80% for practical size MINs with reasonable traffic in the asynchronous transfer mode (ATM) switching environment. Improvement on parallel computer systems with larger size packets is more significant at about 100%. More importantly, the scheme does not require any additional hardware or operational overhead.
Key Words or Keywords (2013)

Keywords are words or phrases which describe content. With the emergence of computerized data bases, keywords are important research tools for search engines, such as GeoRef. Keywords help to ‘tag’ relevant information within an article, and provide a researcher with useful clues to potential important and useful information.
Oriented bounding boxes using multiresolution contours for fast interference detection of arbitrary geometry objects (2016)

Interference detection of arbitrary geometric objects is not a trivial task due to the heavy computational load imposed by implementation issues. The hierarchically structured bounding boxes help us to quickly isolate the contour of segments in interference. In this paper, a new approach is introduced to treat the interference detection problem involving the representation of arbitrary shaped objects. Our proposed method relies upon searching for the best possible way to represent contours by means of hierarchically structured rectangular oriented bounding boxes. This technique handles 2D objects boundaries defined by closed B-spline curves with roughness details. Each oriented box is adapted and fitted to the segments of the contour using second order statistical indicators from some elements of the segments of the object contour in a multiresolution framework. Our method is efficient and robust when it comes to 2D animations in real time. It can deal with smooth curves and polygonal approximations as well results are present to illustrate the performance of the new method.
Differing Prevalence and Diversity of Bacterial Species in Fetal Membranes from Very Preterm and Term Labor (2009)

Bacteria are found in both preterm and term fetal membranes. A greater spread and diversity of bacterial species were found in tissues of women who had very preterm births. It is unclear to what extent the greater bacterial prevalence observed in all vaginal delivery groups reflects bacterial contamination or colonization of membranes during labor. Bacteria positive preterm tissues are associated with histological chorioamnionitis and a pronounced maternal immune paresis.
Tantazoles, unusual cytotoxic alkaloids from the blue-green alga Scytonema mirabile (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTantazoles, unusual cytotoxic alkaloids from the blue-green alga Scytonema mirabileShmuel Carmeli, Richard E. Moore, Gregory M. L. Patterson, Thomas H. Corbett, and Frederick A. ValerioteCite this: J. Am. Chem. Soc. 1990, 112, 22, 8195–8197Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ja00178a070https://doi.org/10.1021/ja00178a070research-articleACS PublicationsRequest reuse permissionsArticle Views482Altmetric-Citations122LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Horizontal transfer of chloroplast genomes between plant species (2012)

The genomes of DNA-containing cell organelles (mitochondria, chloroplasts) can be laterally transmitted between organisms, a process known as organelle capture. Organelle capture often occurs in the absence of detectable nuclear introgression, and the capture mechanism is unknown. Here, we have considered horizontal genome transfer across natural grafts as a mechanism underlying chloroplast capture in plants. By grafting sexually incompatible species, we show that complete chloroplast genomes can travel across the graft junction from one species into another. We demonstrate that, consistent with reported phylogenetic evidence, replacement of the resident plastid genome by the alien genome occurs in the absence of intergenomic recombination. Our results provide a plausible mechanism for organelle capture in plants and suggest natural grafting as a path for horizontal gene and genome transfer between sexually incompatible species.
Method and apparatus for automated thermal imaging of combustor liners and other products (2023)

A method and apparatus are provided for automated non-destructive evaluation (NDE) thermal imaging tests of combustor liners and other products. The apparatus for automated NDE thermal imaging testing of a sample includes a flash lamp positioned at a first side of the sample. An infrared camera is positioned near a second side of the sample. A linear positioning system supports the sample. A data acquisition and processing computer is coupled to the flash lamp for triggering the flash lamp. The data acquisition and processing computer is coupled to the infrared camera for acquiring and processing image data. The data acquisition and processing computer is coupled to the linear positioning system for positioning the sample for sequentially acquiring image data.
Bending Effect of Organic Field-Effect Transistors with Polyimide Gate Dielectric Layers (2005)

We manufactured markedly flexible pentacene field-effect transistors (FETs) on a polyethylenenaphthalate base film with polyimide gate dielectric layers, with a mobility of 0.3 cm 2 /Vs and an on/off ratio of 10 5 . The electric performance of DC current–voltage characteristics was measured by applying compressive and tensile strains while reducing the bending radius down to 3 mm. It was found that the compressive strain leads to an increase in mobility of 10% induced by the change in strain of up to 1.4±0.1%, although the tensile strain leads to a decrease in mobility of 10%. To elucidate the origin of the enhancement of mobility under the compressive strain, we also investigated the strain dependence of capacitance–voltage characteristics for a pentacene channel layer, and almost no change was observed. Our results suggest that the strains markedly affect the spacing between pentacene molecules rather than the number of induced carriers.
Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent (2021)

An operationally simple, scalable, and chemoselective method for the direct phosphorylation of alcohols using a P(V)-approach based on the Ψ-reagent platform is disclosed. The method features a broad substrate scope of utility in both simple and complex settings and provides access to valuable phosphorylated alcohols that would be otherwise difficult to obtain.
The CCK-B antagonist LY288513 blocks effects of diazepam withdrawal on auditory startle (1993)

In order to explore the potential clinical utility of CCK-B antagonists for the treatment of benzodiazepine withdrawal symptoms, the auditory startle reflex was examined in rats undergoing withdrawal from the chronic administration of diazepam. Animals were exposed to diazepam continuously for 12 days (20 mg kg-1 per day) via osmotic minipumps. After 12 days the pumps were removed and the animals were allowed to go through spontaneous withdrawal for 4 days. Acute pretreatment with either diazepam or the selective CCK-B antagonist LY288513 dose-dependently blocked withdrawal-induced increases in the auditory startle response. These results support the hypothesis that the selective CCK-B antagonist LY288513 may be an effective treatment for alleviating at least some benzodiazepine withdrawal symptoms in man.
Dendrimeric silatrane wedges (1997)

The first three generations of a silatrane-containingdendrimeric wedge have been synthesised and isolated. This organosilicon dendrimeric wedge is the first example containing pentacoordinate silicon. The branching multiplicity, M, has been directed in the synthesis method, to form molecule 1 where M = 2 at each silatrane branching point. A second route was used where M = 3, 2 and 1 at successive branching points to form a second generation wedge 2. Electrospray mass spectrometry has been successfully used in the characterisation of the various silatranes. At low cone voltages, the compounds containing a residual trialkanolamine group predominantly show strong multiply charged ions of the type [M + H + xNH4](x+1 )+ (x = 0–3), while those compounds containing epoxy groups, show strong [M + xNH4]x+ ions, where x = 1–4. At high cone voltages the silatranyl cation fragment can be detected.
Visual Tracking Using Color Cameras and Time-of-Flight Range Imaging Sensors (2008)

This work proposes two particle filter-based visual trackers — one using output images from a color camera and the other using images from a time-of-flight range imaging sensor. These proposed trackers were compared in order to identify the advantages and drawbacks of utilizing output images from the color camera as opposed to output from the time-of-flight range imaging sensor for the most efficient visual tracking. This paper is also unique in its novel mixture of efficient methods to produce two stable and reliable human trackers using the two cameras.