gebhart/patrepeval huggingface dataset:
Proteolysis of the Pericellular Matrix (2004)

The 2 major general concepts about the cell biology of atherogenesis, growth of smooth muscle cells, and lipid accumulation in macrophages, ie, foam cell formation, have not been able to satisfactorily explain the genesis of acute coronary syndromes. Rather, the basic pathology behind the acute atherothrombotic events relates to erosion and rupture of unstable coronary plaques. At the cellular level, we now understand that a switch from cellular growth to cellular death, notably apoptosis, could be involved in turning at least some types of atherosclerotic plaques unstable. Because intimal cells require a proper matrix environment for normal function and survival, the vulnerability of an atherosclerotic plaque may critically depend on the integrity of the pericellular matrix of the plaque cells. In vitro studies have revealed that plaque-infiltrating inflammatory cells, such as macrophages, T-lymphocytes, and mast cells, by secreting a variety of proteases capable of degrading pericellular matrix components, induce death of endothelial cells and smooth muscle cells, and so provide a mechanistic explanation for inflammation-dependent plaque erosion and rupture. Thus, a novel link between inflammation and acute coronary syndromes is emerging. For a more explicit understanding of the role of proteases released by inflammatory cells in the conversion of a clinically silent plaque into a dangerous and potentially killing plaque, animal models of plaque erosion and rupture need to be established.
A Lysosomal Cysteine Proteinase from Dictyostelium discoideum Contains N-Acetylglucosamine-1-phosphate Bound to Serine but Not Mannose-6-phosphate on N-linked Oligosaccharides (1996)

Previous studies showed that vegetative Dictyostelium discoideum cells make a lysosomal proteinase, proteinase-1, that contains multiple GlcNAc-alpha-1-P residues in phosphodiester linkage to serine. We extended these studies and, in contrast to earlier reports, found that proteinase-1 contains 7.5 mol of Fuc, 8 mol of Man, 2 mol of Xyl, and 30 mol of GlcNAc per calculated mol of protein but no Man-6-P residues. The protein binds to concanavalin A and wheat germ agglutinin lectin affinity columns, and PNGase-F digestion released most of the mannose and xylose but little of the GlcNAc. beta-Elimination under reducing conditions released only GlcNAc-alpha-1-P. There was no evidence for the release of disaccharides or of fucitol. A rabbit antiserum and monoclonal antibodies prepared against proteinase-1 recognize GlcNAc-alpha-1-P residues in immunoblots and are specifically competed by UDP-GlcNAc or GlcNAc-alpha-1-P. Use of other monoclonal antibodies showed the presence of mannose-6-sulfate on N-linked sugar chains, and alpha-fucose residues on the protein. Thus, proteinase-1 has at least two types of modifications: Glc NAc-alpha-1-P-Ser, which we call phosphoglycosylation, and N-linked oligosaccharides. This is the first purified lysosomal enzyme in Dictyostelium that does not contain Man-6-P residues. The GlcNAc-alpha-1-P-specific antibodies also recognize a group of developmentally regulated proteins, especially enriched in vegetative cells. Some of them are also lysosomal cysteine proteinases, and all bind to the GlcNAc-alpha-1-P-specific monoclonal antibody but not to the mammalian CI-Man-6-P receptor. Conversely, lysosomal enzymes that have Man-6-P do not bind to the GlcNAc-alpha-1-P-specific antibody. An exception to this is beta-N-acetylglucosaminidase, where 15% of the activity binds to this antibody. Thus, there appear to be two sets of lysosomal enzymes with distinct post-translational modifications.
Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives (1988)

alpha-[(3S)-3-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2-oxo-6 or 7-phenylperhydroazepin-1-yl]acetic acids (monoester monoacids) and their dicarboxylic acids were synthesized, and their angiotensin-converting enzyme (ACE) inhibitory activities were evaluated. The dicarboxylic acids having phenyl substituents at the 6R, 6S, and 7S positions on the azepinone ring showed potent inhibition in vitro. The corresponding monoester monoacids, when administered orally, suppressed the pressor response to angiotensin I administered intravenously. The monoester monoacids having the phenyl substituent at the 6-position showed a longer duration of action than one having the substituent at the 7-position. The structure-activity relationship was studied on the basis of the conformational energy calculation.
Design of variable length ring oscillator for clock synthesis (2013)

In this paper, we propose a new architecture of voltage tuning variable length ring oscillator, which can be used in applications such as frequency synthesis, data clock recovery and in phase locked loops (PLLs) based systems. The frequency of the proposed ring oscillator (RO) can be changed dynamically from one frequency to another frequency within a clock period by changing the length of the oscillator electronically. An analog frequency tuning mechanism is also introduced here to make it suitable for applications in PLL based systems. The experimental results from a prototype hardware electronic circuit are presented here to support the validity of the proposed architecture of the RO.
Targeted Therapy in Brain Metastases: Ready for Primetime? (2016)

Brain metastasis is a serious complication of cancer that causes significant morbidity for patients. Over the last decade, numerous new driver somatic mutations have been recognized and targeted therapies are changing the landscape of treatment in lung cancer, breast cancer, and melanoma, which are also the three most common cancers that result in brain metastases. The common actionable mutations include the EGFR mutation and anaplastic lymphoma kinase (ALK) translocations in non–small cell lung cancer, the HER2 mutation in breast cancer, and the BRAF mutation in melanoma. However, most of the early trials with targeted agents excluded patients with brain metastases. With a better understanding of the biology, several recent trials of targeted therapy that focus on brain metastases have been reported and others are ongoing. Novel agents with better penetration across the blood–brain barrier are currently being investigated for patients with brain metastases. In this review, we discuss the current state of use and future directions of targeted therapies in brain metastases.
Comprehending object and process models: an empirical study (1999)

We report the results of an empirical study comparing user comprehension of object oriented (OO) and process oriented (PO) models. The fundamental difference is that while OO models tend to focus on structure, PO models tend to emphasize behaviour or processes. Proponents of the OO modeling approach argue that it lends itself naturally to the way humans think. However, evidence from research in cognitive psychology and human factors suggests that human problem solving is innately procedural. Given these conflicting viewpoints, we investigate empirically if OO models are in fact easier to understand than PO models. But, as suggested by the theory of cognitive fit, model comprehension may be influenced by task-specific characteristics. We therefore compare OO and PO models based on whether the comprehension activity involves: 1) only structural aspects, 2) only behavioral aspects, or 3) a combination of structural and behavioral aspects. We measure comprehension through subjects' responses to questions designed along these three dimensions. Results show that for most of the simple questions, no significant difference was observed insofar as model comprehension is concerned. For most of the complex questions, however, the PO model was found to be easier to understand than the OO model. In addition to describing the process and the outcomes of the experiments, we present the experimental method employed as a viable approach for conducting research into various phenomena related to the efficacy of alternative systems analysis and design methods. We also identify areas where future research is necessary, along with a recommendation of appropriate research methods for empirical examination.
Comparison of Pyrylium and Thiopyrylium Photooxidants in Metal-Free Ring-Opening Metathesis Polymerization (2016)

Systematically varied pyrylium and thiopyrylium photo-oxidants have been evaluated in the metal-free ring-opening-metathesis polymerization (MF-ROMP) of norbornene. Across the series, we observed higher conversion into polynorbornene from thiopyrylium species in comparison with pyrylium salts that were otherwise similarly functionalized. Additionally, more electron-rich photo-oxidants (i.e., weaker oxidants) correlated with higher conversions.
A general framework for assembly planning (1998)

Article A general framework for assembly planning: the motion space approach Share on Authors: Dan Halperin Department of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel Department of Computer Science, Tel Aviv University, Tel Aviv 69978, IsraelView Profile , Jean-Claude Latombe Department of Computer Science, Stanford University, Stanford, CA Department of Computer Science, Stanford University, Stanford, CAView Profile , Randall H. Wilson Eastman Kodak Company, Albuquerque, NM Eastman Kodak Company, Albuquerque, NMView Profile Authors Info & Claims SCG '98: Proceedings of the fourteenth annual symposium on Computational geometryJune 1998 Pages 9–18https://doi.org/10.1145/276884.276886Online:07 June 1998Publication History 8citation507DownloadsMetricsTotal Citations8Total Downloads507Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A Baker−Figgis Isomer of Conventional Sandwich Polyoxometalates. H<sub>2</sub>Na<sub>14</sub>[Fe<sup>III</sup><sub>2</sub>(NaOH<sub>2</sub>)<sub>2</sub>(P<sub>2</sub>W<sub>15</sub>O<sub>56</sub>)<sub>2</sub>], a Diiron Catalyst for Catalytic H<sub>2</sub>O<sub>2</sub>-Based Epoxidation (2001)

A new structural type of sandwich polyoxometalate has been synthesized and characterized. The X-ray structure of this diiron complex, [FeIII2(NaOH2)2(P2W15O56)2], reveals that the junction between the central unit (Fe2Na2) and the trivacant POM units is rotated 60° from that observed in all other known sandwich POMs of this type. The tetra-n-butylammonium salt is an effective catalyst for the H2O2-based epoxidation of alkenes.
RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite (2020)

Macromolecular modeling and design are increasingly useful in basic research, biotechnology, and teaching. However, the absence of a user-friendly modeling framework that provides access to a wide range of modeling capabilities is hampering the wider adoption of computational methods by non-experts. RosettaScripts is an XML-like language for specifying modeling tasks in the Rosetta framework. RosettaScripts provides access to protocol-level functionalities, such as rigid-body docking and sequence redesign, and allows fast testing and deployment of complex protocols without need for modifying or recompiling the underlying C++ code. We illustrate these capabilities with RosettaScripts protocols for the stabilization of proteins, the generation of computationally constrained libraries for experimental selection of higher-affinity binding proteins, loop remodeling, small-molecule ligand docking, design of ligand-binding proteins, and specificity redesign in DNA-binding proteins.
Chemical composition of the volatiles ofDecalepis hamiltonii (Wight & Arn) (2001)

Decalepis hamiltonii root has a strong aromatic odour and its volatiles possess antimicrobial and insecticidal properties. On steam distillation the fresh fleshy roots yielded a volatile oil (0.68%) from which 2-hydroxy-4-methoxybenzaldehyde crystallized out (96%). GC–MS analysis of the oil showed, besides the residual major component, the presence of benzaldehyde (0.017%), salicylaldehyde (0.018%), methyl salicylate (0.044%), benzyl alcohol (0.016%), 2-phenylethyl alcohol (0.081%), ethyl salicylate (0.038%), p-anisaldehyde (0.01%), and vanillin (0.45%), which are minor but significant, olfactorily and biologically. Copyright © 2001 John Wiley & Sons, Ltd.
Bridging core and edge networks for residential subscribers (2000)

We survey various internetworking scenarios between core and edge networks for residential users. The focus is not on individual protocols. Instead we try to show how these protocols can work together. We divide an end-to-end network into core networks and edge networks. We then consider two options for core networks: ATM-based and IP/MPLS-based. For each core/edge architecture, we further consider various access architectures for residential users. We show how these access architectures can be integrated with the two core architectures. Based on the specific requirements of core and edge networks, we discuss the benefits and problems of each solution.
Mobile Gaming on Personal Computers with Direct Android Emulation (2019)

Playing Android games on Windows x86 PCs has gained enormous popularity in recent years, and the de facto solution is to use mobile emulators built with the AOVB (Android-x86 On VirtualBox) architecture. When playing heavy 3D Android games with AOVB, however, users often suffer unsatisfactory smoothness due to the considerable overhead of full virtualization. This paper presents DAOW, a game-oriented Android emulator implementing the idea of direct Android emulation, which eliminates the overhead of full virtualization by directly executing Android app binaries on top of x86-based Windows. Based on pragmatic, efficient instruction rewriting and syscall emulation, DAOW offers foreign Android binaries direct access to the domestic PC hardware through Windows kernel interfaces, achieving nearly native hardware performance. Moreover, it leverages graphics and security techniques to enhance user experiences and prevent cheating in gaming. As of late 2018, DAOW has been adopted by over 50 million PC users to run thousands of heavy 3D Android games. Compared with AOVB, DAOW improves the smoothness by 21% on average, decreases the game startup time by 48%, and reduces the memory usage by 22%.
Adaptive Gaussian quadrature detection for continuous-variable quantum key distribution (2016)

We propose the adaptive quadrature detection for multicarrier continuous-variable quantum key distribution (CVQKD). A multicarrier CVQKD scheme uses Gaussian subcarrier continuous variables for the information conveying and Gaussian sub-channels for the transmission. The proposed multicarrier detection scheme dynamically adapts to the subchannel conditions using a corresponding statistics which is provided by our sophisticated sub-channel estimation procedure. The sub-channel estimation phase determines the transmittance coefficients of the sub-channels, which information are used further in the adaptive quadrature decoding process. We define a technique to estimate the transmittance conditions of the sub-channels. We introduce the terms of single and collective adaptive quadrature detection. We prove the achievable error probabilities, the signal-to-noise ratios, and quantify the attributes of the framework. The adaptive detection scheme allows to utilize the extra resources of multicarrier CVQKD and to maximize the amount of transmittable valuable information in diverse measurement and transmission conditions. The framework is particularly convenient for experimental CVQKD scenarios.
Double‐blind, placebo‐controlled study of magnesium hydroxide for treatment of sensory urgency and detrusor inst ability: preliminary results (1998)

In a prospective, randomised, double-blind, placebo-controlled study 40 women with sensory urgency or detrusor instability randomly received either magnesium hydroxide (group A) or placebo (group B). Pre- and post-treatment symptoms, frequency-volume charts and cystometry results were compared. Eleven of 20 patients receiving magnesium (55%) reported a subjective improvement of their urinary symptoms, compared with five patients taking placebo (20%). In both study groups there was no statistically significant difference in pre- and post-treatment urodynamic parameters in those reporting symptomatic improvement. Magnesium was well tolerated by patients in group A, and no side effects were reported. These results suggest that magnesium hydroxide may be beneficial for detrusor instability or sensory urgency in women.
Container-as-a-Service at the Edge: Trade-off between Energy Efficiency and Service Availability at Fog Nano Data Centers (2017)

In the last few years, we have witnessed the huge popularity of one of the most promising technologies of the modern era: the Internet of Things. In IoT, various smart objects (smart sensors, embedded devices, PDAs, and smartphones) share their data with one another irrespective of their geographical locations using the Internet. The amount of data generated by these connected smart objects will be on the order of zettabytes in the coming years. This huge amount of data creates challenges with respect to storage and analytics given the resource constraints of these smart devices. Additionally, to process the large volume of information generated, the traditional cloud-based infrastructure may lead to long response time and higher bandwidth consumption. To cope up with these challenges, a new powerful technology, edge computing, promises to support data processing and service availability to end users at the edge of the network. However, the integration of IoT and edge computing is still in its infancy. Task scheduling will play a pivotal role in this integrated architecture. To handle all the above mentioned issues, we present a novel architecture for task selection and scheduling at the edge of the network using container-as-a-service (CoaaS). We solve the problem of task selection and scheduling by using cooperative game theory. For this purpose, we developed a multi-objective function in order to reduce the energy consumption and makespan by considering different constraints such as memory, CPU, and the user's budget. We also present a real-time internal and external container migration technique for minimizing the energy consumption. For task selection and scheduling, we have used lightweight containers instead of the conventional virtual machines to reduce the overhead and response time as well as the overall energy consumption of fog devices, that is, nano data centers (nDCs). Our empirical results demonstrate that the proposed scheme reduces the energy consumption and the average number of SLA violations by 21.75 and 11.82 percent, respectively.
Trimming while checking clausal proofs (2013)

Conflict-driven clause learning (CDCL) satisfiability solvers can emit more than a satisfiability result; they can also emit clausal proofs, resolution proofs, unsatisfiable cores, and Craig interpolants. Such additional results may require substantial modifications to a solver, especially if preprocessing and inprocessing techniques are used; however, CDCL solvers can easily emit clausal proofs with very low overhead. We present a new approach with an associated tool that efficiently validates clausal proofs and can distill additional results from clausal proofs. Our tool architecture makes it easy to obtain such results from any CDCL solver. Experimental evaluation shows that our tool can validate clausal proofs faster than existing tools. Additionally, the quality of the additional results, such as unsatisfiable cores, is higher when compared to modified SAT solvers.
A study of the geophysical response of distributed fibre optic acoustic sensors through laboratory‐scale experiments (2016)

ABSTRACT In the past few years, distributed acoustic sensing has gained great interest in geophysics. This acquisition technology offers immense improvement in terms of efficiency when compared with current geophysical acquisition methods. However, the fundamentals of the measurement are still not fully understood because direct comparisons of fibre data with conventional geophysical sensors are difficult during field tests. We present downscaled laboratory experiments that enabled us to characterise the relationship between the signals recorded by conventional seismic point receivers and by distributed fibre optic sensors. Interrogation of the distributed optical fibre sensor was performed with a Michelson interferometer because this system is suited to compact test configurations, and it requires only a very simple data processing workflow for extracting the signal outputs. We show acoustic data that were recorded simultaneously by both the fibre optical interferometer and conventional three‐component accelerometers, thus enabling the comparison of sensor performance. We present results focused on the directionality of fibre measurements, on the amplitude variation with angle of incidence, and on the transfer function that allows accelerometer signals to be transformed into optical fibre signals. We conclude that the optical fibre response matches with the array of the displacement differences of the inline accelerometers deployed along the fibre length. Moreover, we also analysed the influence of various types of coupling and fibre cable coating on the signal responses, emphasising the importance of these parameters for field seismic acquisitions when using the distributed fibre optic technology.
A protocol architecture for transport services in B-ISDN (2002)

The specification and introduction of broadband technologies in local and wide area networks allow the development of novel applications and services. The analysis of these advanced applications and services results in a set of requirements for the transport-oriented functions in the reference model for advanced applications. A transport service derived from these requirements is defined for those applications and categorized into transport service types. A novel protocol reference model (PRM) for broadband integrated services digital network (B-ISDN) transport services, based on the CCITT-PRM, is proposed. A protocol stack for signaling is introduced and analyzed. The asynchronous transfer mode (ATM) adaptation layer (AAL) in the PRM influencing mostly the transport-oriented functions is discussed in detail and transport-oriented protocol stacks are proposed. A brief description of the BERKOM pilot project for B-ISDN is given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition (2012)

Short term focal mIL-4 expression in the hippocampus leads to exacerbation of amyloid deposition in vivo, possibly mediated by acute suppression of glial clearance mechanisms. Given that recent preclinical data from independent groups indicate engagement of the innate immune system early on during disease pathogenesis may be beneficial, our present study strongly argues for a cautious re-examination of unwarranted side-effects of anti-inflammatory therapies for neurodegenerative diseases, including AD.