gebhart/patrepeval huggingface dataset:
Evaluation of Smart Alarm Systems for Industry 4.0 Technologies (2020)

Traditionally, the footwear industry is labor intensive, and cost control is key to ensuring shoe companies can be competitive. The development of Industry 4.0 concepts, used in high-tech industries and blockchain production information systems, enables the creation of smart factories with online alarm management systems, to improve manufacturing efficiency and reduce human resource requirements. In this paper, the performances of the causal association assessment model and the technique for order preference by similarity to the ideal solution (TOPSIS) model in evaluating large data blockchain technologies and quality online real-time early warning systems for production and raw material supplier management are compared, to increase the intelligence of production and to manage product traceability.
Electric Power Market Modeling with Multi-Agent Reinforcement Learning (2023)

Wholegrain cereals are reported to promote beneficial health effects. Wholegrain wheat and rye are almost exclusive sources of alkylresorcinols, and intact alkylresorcinols together with their plasma and urinary metabolites, 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) and 3,5-dihydroxybenzoic acid (DHBA), have been proposed as biomarkers of the intake of these foods in humans. The pharmacokinetics of alkylresorcinols and their metabolites in plasma have been determined but not that of the urinary metabolites. We aimed to characterise the urinary pharmacokinetics of alkylresorcinol metabolites in humans to evaluate their potential as biomarkers of wholegrain wheat and rye. A group of fifteen volunteers followed a low-alkylresorcinol diet for 2 d before ingesting a single dose of rye bread, containing 100 mg alkylresorcinols. Urine was collected between baseline (0 h) and 25 h after administration. Thereafter alkylresorcinol metabolites were quantified by HPLC with coulometric electrode array detection. Maximum excretion rates were observed at 5-6 h for both metabolites, DHPPA being predominant over DHBA and also possessing a greater area under the curve0-25 h. Total urinary recovery between 0 and 25 h yielded 43 % of ingested alkylresorcinols, and at 25 h significant amounts of metabolites were still retained in the body, suggesting that even a spot urine sample may be sufficient to indicate whether or not wholegrain wheat or rye is a daily dietary component. These results support the use of urinary DHPPA and DHBA as biomarkers of wholegrain wheat and rye and enable new potential for studying the association between wholegrain intake and diseases, even in the absence of dietary data.
Molecular analysis of the GYPB gene to infer S, s, and U phenotypes in an admixed population of Minas Gerais, Brazil (2012)

Genotyping was an effective strategy to infer the S, s, and U phenotypes in the admixed population from Minas Gerais (Brazil) and may contribute to transfusion safety.
NUTRIENT MANAGEMENT IN RECIRCULATING HYDROPONIC CULTURE (2004)

There is an increasing need to recirculate and reuse nutrient solutions in order to reduce environmental and economic costs. However, one of the weakest points in hydroponics is the lack of information on managing the nutrient solution. Many growers and research scientists dump out nutrient solutions and refill at weekly intervals. Other authors have recommended measuring the concentrations of individual nutrients in solution as a key to nutrient control and maintenance. Dumping and replacing solution is unnecessary. Monitoring ions in solution is not always necessary; in fact the rapid depletion of some nutrients often causes people to add toxic amounts of nutrients to the solution. Monitoring ions in solution is interesting, but it is not the key to effective maintenance.
Clinical Practice Updates in the Management Of Immune Thrombocytopenia. (2017)

Immune thrombocytopenia (ITP), previously called idiopathic thrombocytopenia purpura, is an autoimmune disorder characterized by a severe reduction in peripheral blood platelet count. In healthy individuals, normal platelet count ranges from 150-450 × 10<sup>9</sup>/L, while in thrombocytopenia counts fall to less than 100 × 10<sup>9</sup>/L.1 In adults, the incidence of ITP is approximately two to four per 100,000.2,3 Bleeding risks, specifically hemorrhage and intracranial hemorrhage, represent the most serious complications for patients with ITP. Over the past decade, the understanding of ITP has expanded greatly, which has contributed to a number of updates in the diagnosis and treatment of the disorder.3 This article aims to briefly review the pathophysiology of ITP and summarize updates in ITP management and treatment options in the adult population.
Improved min-sum decoding algorithms for irregular LDPC codes (2005)

In this paper, we apply two improved min-sum algorithms, the normalized and offset min-sum algorithms, to the decoding of irregular LDPC codes. We show that the behavior of the two algorithms in decoding irregular LDPC codes is different from that in decoding regular LDPC codes, due to the existence of bit nodes of degree two. We analyze and give explanations to the difference, and propose approaches to improve the performance of the two algorithms.
Impact of Manual Service Disconnect in an Automotive Traction Battery System (RESS) (2017)

<div class="section abstract"><div class="htmlview paragraph">SAE standards require the function of a Manual Service Disconnect (MSD), when open, to remove any voltage between positive and negative Rechargeable Energy Storage System (RESS) output terminals. Another SAE standard specifies that measured voltage across all external battery terminal sets shall be less than 60 VDC within 5 seconds after the manual disconnect is actuated with the automatic disconnect (e.g., contactors) closed. In this paper, the location of the manual service disconnect is reviewed to meet isolation requirement of the battery pack system (i.e., RESS). Battery architectures with manual service disconnect located at the most positive side, most negative side, and center of the array or the pack were studied. Voltage measurement points and single point failure modes were considered. It was found that MSD location for a single contactor pack is most effective in reducing voltage potential at the terminals when placed on the other side of the contactor. Optimum location and design of service disconnect offer a battery system installed, utilized, and serviced effectively in an electrified vehicle.</div></div>
Defining the Q<sub>P</sub>‐site of <i>Escherichia coli</i> fumarate reductase by site‐directed mutagenesis, fluorescence quench titrations and EPR spectroscopy (2004)

We have used fluorescence quench titrations, EPR spectroscopy and steady-state kinetics to study the effects of site-directed mutants of FrdB, FrdC and FrdD on the proximal menaquinol (MQH(2)) binding site (Q(P)) of Escherichia coli fumarate reductase (FrdABCD) in cytoplasmic membrane preparations. Fluorescence quench (FQ) titrations with the fluorophore and MQH(2) analog 2-n-heptyl-4-hydroxyquinoline-N-oxide (HOQNO) indicate that the Q(P) site is defined by residues from FrdB, FrdC and FrdD. In FQ titrations, wild-type FrdABCD binds HOQNO with an apparent K(d) of 2.5 nM, and the following mutations significantly increase this value: FrdB-T205H (K(d) = 39 nM); FrdB-V207C (K(d) = 20 nM); FrdC-E29L (K(d) = 25 nM); FrdC-W86R (no detectable binding); and FrdD-H80K (K(d) = 20 nM). In all titrations performed, data were fitted to a monophasic binding equation, indicating that no additional high-affinity HOQNO binding sites exist in FrdABCD. In all cases where HOQNO binding is detectable by FQ titration, it can also be observed by EPR spectroscopy. Steady-state kinetic studies of fumarate-dependent quinol oxidation indicate that there is a correlation between effects on HOQNO binding and effects on the observed K(m) and k(cat) values, except in the FrdC-E29L mutant, in which HOQNO binding is observed, but no enzyme turnover is detected. In this case, EPR studies indicate that the lack of activity arises because the enzyme can only remove one electron from reduced MQH(2), resulting in it being trapped in a form with a bound menasemiquinone radical anion. Overall, the data support a model for FrdABCD in which there is a single redox-active and dissociable Q-site.
Magnetic field enhanced performance of a copper hollow anode cathode laser (1992)

The output beam power and small-signal unsaturated gain on the He-Cu 780.8 nm transition in a hollow slotted-anode cathode laser are increased significantly by the application of a longitudinal magnetic field and each shows a marked dependence on the field in the range 10 to 40 mT. The laser output power and the gain increase with the discharge current, while the optimum magnetic field (∼22 mT) results in a further significant increase both in output power and gain. These effects have their origin in the transverse deflection of the beam electrons by the magnetic field.
Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts (2010)

A number of recent discoveries indicate that abnormal Ca2+ signaling, oxidative stress, and mitochondrial dysfunction are involved in the neuronal damage in Alzheimer's disease. However, the literature on the interactions between these factors is controversial especially in the interpretation of the cause-effect relationship between mitochondrial damage induced by Ca2+ overload and the production of reactive oxygen species (ROS). In this review, we survey the experimental observations on the Ca2+-induced mitochondrial ROS production, explain the sources of controversy in interpreting these results, and discuss the different molecular mechanisms underlying the effect of Ca2+ on the ROS emission by brain mitochondria.
On the K-Winners-Take-All Network (1988)

We present and rigorously analyze a generalization of the Winner-Take-All Network: the K-Winners-Take-All Network. This network\nidentifies the K largest of a set of N real numbers. The\nnetwork model used is the continuous Hopfield model.
The Effect of Serum on Monolayer Cell Culture of Mammalian Articular Chondrocytes (1980)

Large variations were found in the ability of six species of sera to support growth of rabbit, human and dog articular chondrocytes in monolayer culture. In most instances the DNA content of the cell pellets increased directly as the serum concentration rose from 10 to 30%. Indications of inhibitory as well as growth-promoting actions were found in some sera. Stimulation of rabbit chondrocyte proliferation by increasing concentrations of serum was accompanied by a reduction of radiosulfate incorporation and cell protein content. There was no consistent relation between the response of chondrocytes from a given species and its homologous serum. However, the growth of human chondrocytes was greatly potentiated by human serum provided that interference with initial attachment of the cells to the culture flask by homologous serum was overcome by priming with fetal calf serum.
Simple and cost-effective fluorescent labeling of 5-hydroxymethylcytosine (2016)

The nucleobase 5-hydroxymethylcytosine (5-hmC), a modified form of cytosine, is an important epigenetic mark related to regulation of gene expression. 5-hmC levels are highly dynamic during early development and are modulated during the progression of neurodegenerative disease and cancer. We describe a spectroscopic method for the global quantification of 5-hmC in genomic DNA. This method relies on the enzymatic glucosylation of 5-hmC, followed by a glucose oxidation step that results in the formation of aldehyde moieties that are covalently linked to a fluorescent reporter by oxime ligation. The fluorescence intensity of the labeled sample is directly proportional to its 5-hmC content. We show that this simple and cost-effective technique is suitable for quantification of 5-hmC content in different mouse tissues.
Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression in Human T Cells Is Regulated by Phosphotyrosyl Phosphatase Activity (2001)

Intercellular adhesion molecule-1 (ICAM-1) plays an important role in adhesion phenomena involved in the immune response. The strength of adhesion has been shown to be modulated by changes in ICAM-1 gene expression. In T cells, signaling pathways are intimately regulated by an equilibrium between protein-tyrosine kinases and protein tyrosine phosphatases (PTP). The use of bis-peroxovanadium (bpV) compounds, a class of potent PTP inhibitors, enabled us to investigate the involvement of phosphotyrosyl phosphatases in the regulation of ICAM-1 gene expression in human T cells. Here, we demonstrate for the first time that inhibition of PTP results in an increase of ICAM-1 surface expression on both human T lymphoid and primary mononuclear cells. The crucial role played by the NF-kappaB-, Ets-, and pIgammaRE-binding sites in bpV[pic]-mediated activation of ICAM-1 was demonstrated using various 5' deletion and site-specific mutants of the ICAM-1 gene promoter driving the luciferase reporter gene. Co-transfection experiments with trans-dominant mutants and electrophoretic mobility shift assays confirmed the importance of constitutive and inducible transcription factors that bind to specific responsive elements in bpV-dependent up-regulation of ICAM-1 surface expression. Altogether, these observations suggest that expression of ICAM-1 in human T cells is regulated by phosphotyrosyl phosphatase activity through NF-kappaB-, Ets-, and STAT-1-dependent signaling pathways.
The chicken liver cation-independent mannose 6-phosphate receptor lacks the high affinity binding site for insulin-like growth factor II (1989)

The chicken liver cation-independent mannose 6-phosphate receptor has been purified to apparent homogeneity by affinity chromatography on pentamannose phosphate-Sepharose and tested for its ability to bind iodinated human IGF-I, human IGF-II, and chicken IGF-II. In contrast to the bovine, rat, and human cation-independent mannose 6-phosphate receptors, which bind human IGF-II and IGF-I with nanomolar and micromolar affinities, respectively, the chicken receptor failed to bind either radioligand at receptor concentrations as high as 1 microM. The bovine receptor binds chicken IGF-II with high affinity while the chicken receptor binds this ligand with only low affinity, which we estimate to be in the micromolar range. These data demonstrate that the chicken cation-independent mannose 6-phosphate receptor lacks the high affinity binding site for IGF-II. These results provide an explanation for the failure of previous investigators to identify the type II IGF receptor by IGF-II cross-linking to chicken cells and indicate that the mitogenic activity of IGF-II in chick embryo fibroblasts is most likely mediated via the type I IGF receptor.
Component-Mode Reduced-Order Models for Geometric Mistuning of Integrally Bladed Rotors (2014)

Two methods that explicitly model airfoil geometry surface deviations for mistuning prediction in integrally bladed rotors are developed by performing a modal analysis on different degrees of freedom of a parent reduced-order model. The parent reduced-order model is formulated with Craig–Bampton component-mode synthesis in cyclic symmetry coordinates for an integrally bladed rotor with a tuned disk and airfoil geometric deviations. The first method performs an eigenanalysis on the constraint-mode degrees of freedom that provides a truncated set of interface modes, whereas the second method includes the disk fixed-interface normal mode in the eigenanalysis to yield a truncated set of ancillary modes. Both methods can use tuned or mistuned modes, where the tuned modes have the computational benefit of being computed in cyclic symmetry coordinates. Furthermore, the tuned modes only need to be calculated once, which offers significant computational savings for subsequent mistuning studies. Each geometric mistuning method relies upon the use of geometrically mistuned airfoil modes in the component-mode framework to provide a very accurate reduced-order model. Free and forced response results are compared to both the full finite-element model solutions and a traditional frequency-based approach used widely in academia and the gas-turbine industry. It is shown that the developed methods provide highly accurate results with a significant reduction in solution time compared to the full finite-element model and parent reduced-order model.
Frag: A distributed approach to display wall gaming (2006)

Computer games with distributed functionality, such as most modern multiplayer games, provide a rich environment in which one can experiment with high performance distribution of computational and graphical resources. Their extremely high requirements for processing power and consistent visual output create a platform with unique demands. \n\nCurrent tiled display walls provide, as a consequence of their architecture, a large amount of computational resources in the form of a networked cluster of computers, driving the individual tiles. Existing forays into creating games intended for display walls have unfortunately made little use of this power, opting instead to centralise computation on a single host and distributing the resulting graphical information, or by running the same computations on all hosts and displaying different parts of the locally generated information. \n\n\nWe seek to remedy this situation by distributing computation and visualisation in order to exploit available resources to a greater degree. Achieving a higher level of resource utilisation will allow increasing the complexity of games to involve larger environments with more interactive entities than on comparative single host systems. These are approaches that are used to some degree in Massively Multiplayer Online Games, though rarely with the same focus on distribution or the same demands for visual consistency between adjoining tiles that on a display wall. \n\n\nThis thesis discusses techniques for determining and distributing a continually evolving set of information to a cluster of heterogeneous hosts connected by a network. The hosts will be able to simulate a set of mobile entities, where all entities on all hosts share a single virtual environment in which they can interact with each other while keeping a shared and consistent view of the world state. furthermore, the approach is tailored to visualisation on a display wall. \n\n\nTo avoid having to design games specifically for the distributed system presented herein, a library is introduced as a method of removing all distribution-related responsibilities from the game itself, as long as the game supports a simple common interface and a limited set of callbacks for the library to modify the game. Do demonstrate the feasibility of this approach and study some of its properties, the Frag library is implemented as a prototype according to the specified design. An ordinary computer game is modified to use Frag, after which the system is tested and measured, leading to comparisons between the original and the Frag-enabled game in terms of scalability in game complexity, in addition to observations about the suitability of the approach.
Trio Mediates Netrin-1-Induced Rac1 Activation in Axon Outgrowth and Guidance (2008)

The chemotropic guidance cue netrin-1 promotes neurite outgrowth through its receptor Deleted in Colorectal Cancer (DCC) via activation of Rac1. The guanine nucleotide exchange factor (GEF) linking netrin-1/DCC to Rac1 activation has not yet been identified. Here, we show that the RhoGEF Trio mediates Rac1 activation in netrin-1 signaling. We found that Trio interacts with the netrin-1 receptor DCC in mouse embryonic brains and that netrin-1-induced Rac1 activation in brain is impaired in the absence of Trio. Trio(-/-) cortical neurons fail to extend neurites in response to netrin-1, while they are able to respond to glutamate. Accordingly, netrin-1-induced commissural axon outgrowth is reduced in Trio(-/-) spinal cord explants, and the guidance of commissural axons toward the floor plate is affected by the absence of Trio. The anterior commissure is absent in Trio-null embryos, and netrin-1/DCC-dependent axonal projections that form the internal capsule and the corpus callosum are defective in the mutants. Taken together, these findings establish Trio as a GEF that mediates netrin-1 signaling in axon outgrowth and guidance through its ability to activate Rac1.
Don't forget the laptop (2007)

We draw on our experiences with the Princeton Laptop Orchestra to discuss novel uses of the laptop's native physical inputs for flexible and expressive control. We argue that instruments designed using these built-in inputs offer benefits over custom standalone controllers, particularly in certain group performance settings; creatively thinking about native capabilities can lead to interesting and unique new interfaces. We discuss a variety of example instruments that use the laptop's native capabilities and suggest avenues for future work. We also describe a new toolkit for rapidly experimenting with these capabilities.
The Toxicity of Phenothiazine (1994)

Phenothiazine, the parent compound of a multitude of present-day drugs, has been employed on an extensive scale for its insecticidal, fungicidal, antibacterial and anthelmintic properties. Almost a catholicon, its widespread use in animals and man has led to the uncovering of many adverse reactions encompassing effects on blood elements, neuromuscular problems and photosensitization. The high lipophilicity of phenothiazine and the formation of two redox systems amongst its many metabolites can facilitate the occurrence of generalised macromolecular disruption. Information from the literature has been garnered and appraised in this review to enable an insight into the possible mode(s) of interaction of phenothiazine with living systems.
Ureidotriazine-Based Supramolecular Copolymers (2003)

Ureidotriazine-Based supramol. polymers were prepd. from hydroxyterminated poly(ethylene butylene)s by cyanoethylation with acrylonitrile, redn. to the amine-terminated polymer, conversion to the isocyanate with phosgene, and finally reaction with trialkoxyphenyldiaminotriazine. The polymers were characterized for the morphol., discotic liq. cryst. melting temp., and their blends.
Effect of Cropping System on Residual Soil P from Poultry Litter Application (1997)

When poultry litter (PL) is applied to meet the nitrogen (N) needed for plant growth, phosphorus (P) can accumulate, leading to non-point source pollution of surface water. This study was conducted at Overton, Texas on a Bowie fine sandy loam (fine-loamy, siliceous, thermic, Plinthic Paleudults) to investigate the use of warm- and cool-season forage legumes in rotational cropping systems to remove excess P. Cropping systems were: spring legume—fall vegetable (SL-FV), spring vegetable—fall legume (SV-FL), and spring vegetable-fall vegetable (SV-FV). Warm- and cool-season legumes were Iron and Clay cowpea and crimson clover, respectively. Poultry litter rates were 0, 1X, 2X, 4X, and commercial blend (CB) as subplots. Fertility treatments were applied to vegetable plots only. The crop, IX PL and CB rate for each season were: spring 1995—watermelon, 2.2 t·ha -1 , 48.8N—12.2P—28K kg·ha -1 ; fall 1995—turnip, 8.3 t·ha -1 , 89.6N—24.4P—28K kg·ha -1 ; spring 1996—tomato, 6.7 t·ha -1 , 100.9N—17.1P—78.5K kg·ha -1 . Soil P increased at all depths sampled (0-15, 15-30, and 30-45 cm) as PL rate increased. Residual P from CB was equal to the control. Through spring 1996, soil P concentration in the surface 0-15 cm was increased by all systems. System SV-FL reduced P accumulation by 35.6 mg·kg -1 when compared to SL-FV and 44.7 mg·kg -1 when compared to SV-FV. Residual P continued to increase as PL rate increased. Rate of increase was reduced by a system of SV-FL.