gebhart/patrepeval huggingface dataset:
Insulin-like Growth Factor (IGF)-I, -II, IGF Binding Proteins (IGFBP)−3, −4, and −5 Levels in the Conditioned Media of Normal Human Bone Cells Are Skeletal Site-Dependent (1997)

The skeleton in its function of affording strength and support to the body is subject to differential mechanical loading which has been implicated to mediate some of its effects on bone formation via the insulin-like growth factors (IGFs), which are important regulators of bone metabolism. We, therefore, sought to conduct the present study with the hypothesis that the skeletal site-dependent differences in mechanical loading and other variables including stage of osteoblast differentiation would be associated with site-specific differences in the production of the IGF system components. To test this hypothesis, conditioned media (CM) from normal human bone cells (control and IGF-II-treated 48-h cultures) from five different skeletal sites were obtained and assayed for IGF-I, IGF-II (following separation of IGF binding proteins [IGFBPs]), IGFBP-3, IGFBP-4, and IGFBP-5 protein levels employing specific radioimmunoassays for each protein. IGF-I levels were lower than any other IGF system component but were significantly different between the various sites tested. IGF-II levels were greatest in the CM from mandibular cells, followed by calvarial and rib cells, and least in the marrow stromal cells. IGFBP-3 levels were highest in the CM of vertebral cells and lowest in the CM of rib and mandibular cells. The relative abundance of IGFBP-4 in decreasing order was observed in mandibular, calvarial, vertebral, rib, and stromal cells' CM. IGFBP-5 was produced maximally by the calvarial cells, followed by the mandibular, vertebral, stromal, and rib cells. IGFBP-4 appeared to be the IGF system component most abundantly produced by all the cell types from the skeletal sites tested. On a molar basis, the IGFBPs in general were estimated to be produced at a higher magnitude than the IGFs. These findings indicate that there are skeletal site-dependent differences in the production of IGF system components and suggest that the regulation of bone metabolism may vary at the various skeletal sites.
Stable Light-Emitting Diodes Using Phase-Pure Ruddlesden-Popper Layered Perovskites (2017)

International audience
Modular measurement data acquisition and logging system with network access (2012)

We report on the design of a data acquisition and logging system capable of simplifying data analysis by concentrating heterogeneous data onto one logging unit. For this purpose an intermediate interface connecting the data sources to the logging unit is proposed. This interface is designed such that generic embedded systems or desktop computer hardware can be utilized as logging unit, enabling network access to the data with minimal additional effort. Following a description of the overall architecture and the system components, we present our application of the system as part of a research project in multiplexed fiber sensors currently being conducted in our laboratory.
Normal square wave jerks. (1981)

Fixation stability of the saccadic system was investigated by infrared reflection oculography in 29 normal subjects, young and elderly. Square wave jerks consisting of spontaneous horizontal saccadic excursions of 0.5 degree and over, followed some 200 msec later by corrective saccades, were recorded in 24% of subjects. The frequency of square wave jerks in the elderly was significantly higher than in young subjects. The results suggest that square wave jerks more frequent than 9/min in young patients can be considered abnormal.
[In vitro study on two kind of recombinant adeno-associated virus-mediated transfection efficiency with enhanced green fluorescent protein into rats osteoblasts]. (2010)

The transfection efficiency of two kind of virus vectors was both very high and rAAV2/6's is higher than that of rAAV2/9. This suggested the potential of rAAV-EGFP as a safe and efficient vector for gene therapy.
Synthesis of sulfur-containing heterocyclic compounds by cyclocondensation of acetylenic derivatives of anthraquinone with sodium sulfide (2003)

Reaction of vicalkynylchloro-and vicchloro-(1-oxoalk-2-ynyl)-anthraquinones with Na 2 S in ethanol, with short heating, has been shown to afford anthrathiophenediones and anthrathiopyrantriones, respectively, generally in good yields. Under the same conditions, 1alkynylanthraquinones also undergo cyclocondensation to give anthra[2,1-b]thiophene-6,11diones.
Lack of type C virus antibodies in systemic lupus erythematosus. (1982)

Twelve systemic lupus erythematosus (SLE) and 10 normal sera were similarly reactive in an assay for cytotoxic antibody to type C virus-infected and uninfected cells, but both were less cytotoxic for infected cells. Thus antibodies to type C viruses were not detected in SLE or normal sera, but type C infection may interfere with antibody recognition of other cell membrane antigens.
A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth (2012)

We conducted a systematic analysis to determine the reason for the apparent disparity of success of immunotherapy between clinical and experimental cancers. To do this, we performed a search of PubMed using the keywords "immunotherapy" AND "cancer" for the years of 1980 and 2010. The midspread of experimental tumors used in all the relevant literature published in 2010 were between 0.5-121 mm(3) in volume or had grown for four to eight days. Few studies reported large tumors that could be considered representative of clinical tumors, in terms of size and duration of growth. The predominant effect of cancer immunotherapies was slowed or delayed outgrowth. Regression of tumors larger than 200 mm(3) was observed only after passive antibody or adoptive T cell therapy. The effectiveness of other types of immunotherapy was generally scattered. By comparison, very few publications retrieved by the 1980 search could meet our selection criteria; all of these used tumors smaller than 100 mm(3), and none reported regression. In the entire year of 2010, only 13 used tumors larger than 400 mm(3), and nine of these reported tumor regression. Together, these results indicate that most recent studies, using many diverse approaches, still treat small tumors only to report slowed or delayed growth. Nevertheless, a few recent studies indicate effective therapy against large tumors when using passive antibody or adoptive T cell therapy. For the future, we aspire to witness the increased use of experimental studies treating tumors that model clinical cancers in terms of size and duration of growth.
Mystic: Predictive Scheduling for GPU Based Cloud Servers Using Machine Learning (2016)

GPUs have become the primary choice of accelerators for high-end data centers and cloud servers, which can host thousands of disparate applications. With the growing demands for GPUs on clusters, there arises a need for efficient co-execution of applications on the same accelerator device. However, the resource contention among co-executing applications causes interference which leads to degradation in execution performance, impacts QoS requirements of applications and lowers overall system throughput. While previous work has proposed techniques for detecting interference, the existing solutions are either developed for CPU clusters, or use static profiling approaches which can be computationally intensive and do not scale well. We present Mystic, an interference-aware scheduler for efficient co-execution of applications on GPU-based clusters and cloud servers. The most important feature of Mystic is the use of learning-based analytical models for detecting interference between applications. We leverage a collaborative filtering framework to characterize an incoming application with respect to the interference it may cause when co-executing with other applications while sharing GPU resources. Mystic identifies the similarities between new applications and the executing applications, and guides the scheduler to minimize the interference and improve system throughput. We train the learning model with 42 CUDA applications, and consider another separate set of 55 diverse, real-world GPU applications for evaluation. Mystic is evaluated on a live GPU cluster with 32 NVIDIA GPUs. Our framework achieves performance guarantees for 90.3% of the evaluated applications. When compared with state-of-the art interference-oblivious schedulers, Mystic improves the system throughput by 27.5% on average, and achieves a 16.3% improvement on average in GPU utilization.
The Use of Mixed Organic/Ionic Liquid Electrolytes with Forcespun Metal Oxides/Carbon Microfiber Electrodes in Lithium Ion Batteries (2018)

We present results on the Forcespinning (FS) of Polyacrylonitrile (PAN) solution precursors for the mass production of carbon and SnO2/Carbon composite fibers as anode materials for Lithium-ion batteries. Mixed organic/ionic liquid electrolytes (MOILEs) were employed in Lithium ion cell cycling studies with the carbon fiber and SnO2/C composite fiber anodes to investigate the electrochemical and cycling performance of the Li-ion cells. The carbon fibers cycled with 1 M LiTFSI in 60% EMI-TFSI and 40% EC/DMC (1:1 v/v) with 5 wt% SN electrolyte had a specific capacity of ~201 mAhg-1 at 100 mAg-1 after 100 cycles. Similarly, results were obtained on carbon fibers using 1 M LiPF6 in EC/DMC (1:1 v/v) electrolyte. The SnO2/C composite fibers, with 1 M LiTFSI in 60% EMI-TFSI and 40% EC/DMC (1:1 v/v) with 5 wt% SN, delivered a specific capacity of ~298 mAhg-1 at 100 mAg-1 after 100 cycles.
Optimization in integrated biochemical systems (1992)

As of yet, steady-state optimization in biochemical systems has been limited to a few studies in which networks of fluxes were optimized. These networks of fluxes are represented by linear (stoichiometric) equations that are used as constraints in a linear program, and a flux or a sum of weighted fluxes is used as the objective function. In contrast to networks of fluxes, systems of metabolic processes have not been optimized in a comparable manner. The primary reason is that these types of integrated biochemical systems are full of synergisms, antagonisms, and regulatory mechanisms that can only be captured appropriately with nonlinear models. These models are mathematically complex and difficult to analyze. In most cases it is not even possible to compute, let alone optimize, steady-state solutions analytically. Rare exceptions are S-system representations. These are nonlinear and able to represent virtually all types of dynamic behaviors, but their steady states are characterized by linear equations that can be evaluated both analytically and numerically. The steady-state equations are expressed in terms of the logarithms of the original variables, and because a function and its logarithms of the original variables, and because a function and its logarithm assume their maxima for the same argument, yields or fluxes can be optimized with linear programs expressed in terms of the logarithms of the original variables.
Dietary L-Arginine Attenuates Blood Pressure in Mineralocorticoid-Salt Hypertensive Rats (1995)

The present study was designed to investigate the influence of dietary L-arginine supplementation on blood pressure and on ex vivo vascular reactivity in mineralocorticoid-salt (DOCA-salt) hypertensive rats. Systolic blood pressure and heart rate were determined throughout the experimental period in unanaesthetized rats. Plasma and urine electrolyte levels were measured. Vasoconstrictor response to noradrenaline and vasodilator responses to acetylcholine and sodium nitroprusside were evaluated in the isolated perfused mesenteric vascular bed. DOCA-salt hypertensive rats were divided into 2 groups: a control group and a treated group receiving 0.8% L-arginine supplementation in drinking water. Dietary L-arginine supplementation attenuated systolic blood pressure in conscious DOCA-salt hypertensive rats, but did not modify heart rate. Plasma calcium and sodium concentrations and urinary magnesium excretion were decreased by L-arginine supplementation. Noradrenaline-induced vasoconstriction decreased and acetylcholine-induced vasodilatation increased, whereas sodium nitroprusside-induced vasodilatation was not modified, in the L-arginine-supplemented rats. It is concluded that dietary L-arginine supplementation in the diet lowers systolic blood pressure in DOCA-salt hypertensive rats, probably through vascular action.
Latinx Parents' Perceptions of Neighborhood Walking Safety for Their Youth With Intellectual Disabilities (2020)

Increased walking distance and frequency has been linked to positive health outcomes. Neighborhood walkability disproportionately impacts youth with intellectual and developmental disabilities (IDD). We investigated concerns of Latinx parents of youth with IDD about walkability and their impact on families' walking behavior. We surveyed Latinx parents of youth with IDD (n = 21) and compared results with the general population. Results were triangulated with a focus group (n = 5). Survey data were analyzed using a Mann-Whitney U test, and focus group data via thematic analysis. We found a significant difference (P < .05) between parents of youth with IDD and the general population on perceived aesthetics, opportunity to participate, and satisfaction. Latinx parents and their youth with IDD experience disparities in the safety and pleasantness of their communities for walking, which may contribute to decreased community participation, poorer health outcomes, and lower levels of neighborhood satisfaction among this already vulnerable population.
Phase I clinical trial of imexon: A mitochondrial thiol oxidant (2004)

3181 Background: Imexon is a thiol-binding small molecule which induces mitochondrial oxidation, a loss of membrane potential and cytochrome C, leading to apoptosis (Blood 97: 3544–50, 2001). In rodents and dogs the drug is schedule dependent favoring daily dosing with an MTD of 450mg/M2/day. Previous phase I trials showed that fixed IV doses of 100–200 mg produced minimal GI toxicities and a few objective responses: 1 CR each in NSCLC and melanoma, and 1 PR in breast cancer (Cancer Treat Sympos 1:27–35, 1985). New supplies of imexon were synthesized under a RAID grant from the NCI, allowing for a phase I dose-escalation study to be performed in patients with advanced, refractory cancers. Methods: An accelerated titration dose escalation design was chosen for the phase 1 trial using a starting dose of 20 mg/M2/day for 5 consecutive days, repeated every other week for one month. One patient per dose level is accrued until any grade 2 or greater drug-related toxicity occurs, then a standard 3 patient cohort will be used to define the MTD as any grade 3 toxicity occurring in 2/6 patients at a dose level. The primary endpoint is to establish the MTD and safety of this schedule. Secondary endpoints include imexon pharmacokinetics and RBC glutathione (GSH) levels as a possible biomarker of activity. Laboratory studies have shown a transient, dose-dependent decrease in GSH in RBC's when imexon is added to whole human blood. Results: Three dose-escalation steps have been performed without reaching the MTD. The current dose level is 80mg/M2/day. No drug-related grade 3 toxicities have occurred and the only complaints have been mild nausea. Further accrual is targeting melanoma and pancreatic cancer patients wherein orphan drug designations have been obtained for the drug from the FDA. Conclusions: The prior fixed doses of imexon do not approximate the MTD of the drug given on a daily x 5 schedule. The lack of myelosuppression, and the newly discovered mechanism of thiol oxidation makes imexon an attractive agent with to combine with other cytotoxic drugs. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AmpliMed Corp. AmpliMed
Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP). (1994)

We investigated immunohistochemically the distribution in rats of the homologous proteins gp330 and the LDL receptor-related protein (LRP/alpha 2MR), and a receptor-associated protein (RAP), and the sites to which soluble exogenous RAP binds. We found gp330 in a restricted group of epithelial cells, including renal proximal tubule cells, podocytes, Type II pneumocytes, cells of the parathyroid, thyroid, epididymis, lining of the uterus, ependyma, retina, ciliary body, yolk sac, and placenta. In these cells gp330 was detected mainly at the cell surface, except for parathyroid and retinal epithelial cells, where diffuse cell staining was found. LRP/alpha 2MR was widely distributed in interstitial cells, notably in fibroblasts and macrophages, and was also present in a selected group of epithelial or specialized cells, including hepatocytes, adrenal cortical cells, follicular cells of the ovary, cells of the choroid plexus, ciliary body, mesangial cells, and some neurons. In certain cells, notably hepatocytes and adrenal cortical cells, LRP/alpha 2MR was detected mainly on the surface, but in others, including macrophages, fibroblasts, and epithelial cells of the choroid plexus and ciliary body, staining throughout the cell was seen. The only cells that clearly expressed both LRP/alpha 2MR and gp330 were retinal and ciliary epithelial cells. RAP was found in intracellular vesicles in all cells that expressed gp330 or LRP/alpha 2MR. RAP was not definitely detected on the cell surface. Binding sites for RAP were found on the surface of those cells with surface gp330 or LRP, and also throughout the cytoplasm in cells with diffuse cellular LRP/alpha 2MR or gp330. Because of their different locations, we conclude that gp330 and LRP/alpha 2MR serve distinct functions in vivo, despite similarities in ligand-binding properties observed in vitro. Since RAP is found largely within cells, its major physiological function may be concerned with intracellular assembly or trafficking of the receptors to which it binds.
Exercise can help modulate human gut microbiota (2014)

Moderate exercise has been shown to be beneficial to health in many ways, including reducing stress, building a stronger immune system and increasing cardiovascular health.Recent studies in the human gut microbiome have demonstrated benefits of certain microorganisms in aiding human pathogen resistance and reduction of inflammation.The hypothesis is that exercise can help modulate the human gut microbiota.Here we show that increasing exercise frequency selects for a diverse community of microbes that contribute to a healthier environment.Individuals who exercised more often showed a significant elevation in their diversity, as well as a significant elevation of certain members of the Firmicutes phylum (including Faecalibacterium prausnitzii, uncharacterized species of genus Oscillospira, Lachnospira, Coprococcus, and uncharacterized families of Clostridiales).
Optical gain in carbon nanotubes (2010)

Semiconducting single-wall carbon nanotubes (s-SWNTs) have proved to be promising material for nanophotonics and optoelectronics. Due to the possibility of tuning their direct band gap and controlling excitonic recombinations in the near-infrared wavelength range, s-SWNT can be used as efficient light emitters. We report the first experimental demonstration of room temperature intrinsic optical gain as high as 190 cm−1 at a wavelength of 1.3 μm in a thin film doped with s-SWNT. These results constitute a significant milestone toward the development of laser sources based on carbon nanotubes for future high performance integrated circuits.
Lipid Productivity of Algae Grown on Dairy Wastewater as a Possible Feedstock for Biodiesel (2008)

The objective of this thesis is to develop a biological wastewater treatment system that utilizes algal growth to simultaneously create renewable energy in the form of biodiesel and digester biogas, remove polluting nutrients, and abate greenhouse gases. Research under the Department of Energy Aquatic Species Program during 1978-1996 concluded that cultivating algae for biofuels was cost prohibitive at that time and that an integrated approach should be studied that combined wastewater treatment with algal biofuel production. Nutrient removal, in particular nitrogen and phosphorus, from wastewater is a growing regulatory need and the use of algae cultivation could create a unique marriage between waste treatment and biofuel production. To investigate this possible synergy, bench-scale tests were conducted to determine potential algal lipid productivity with mixed-cultures of algae grown on anaerobically-pretreated dairy wastewater in batch mode. The total lipid content of the algae ranged from 8% to 29% of algal mass. Maximum biomass concentration reached 920 mg/L, measured as volatile suspended solids, on Day 13 of incubation. In contrast, maximum total lipid content was reached at Day 6, corresponding to a lipid productivity of 2.8 g/m^2/day, or 1,200 gallons/acre/year if scaled up. Nutrient removal over 12 days of incubation was nearly complete. Total ammonia (NH3+NH4+) was reduced 96% to 1.1 mg/L as N, and phosphate (PO4^3-) was reduced >99% from an initial concentration of 2.5 mg/L PO4 as P.
Data complexity of reasoning in very expressive description logics (2005)

Data complexity of reasoning in description logics (DLs) estimates the performance of reasoning algorithms measured in the size of the ABox only. We show that, even for the very expressive DL SHIQ, satisfiability checking is data complete for NP. For applications with large ABoxes, this can be a more accurate estimate than the usually considered combined complexity, which is EXPTIMEcomplete. Furthermore, we identify an expressive fragment, Horn-SHIQ, which is data complete for P, thus being very appealing for practical usage.
Metal nanoparticles: understanding the mechanisms behind antibacterial activity (2017)

As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.
Stem Cell Niches for Skin Regeneration (2012)

Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space have been closely investigated as model systems for niche-driven regeneration. These studies suggest that stem cell strategies for skin engineering must consider the intricate molecular and biologic features of these niches. Innovative biomaterial systems that successfully recapitulate these microenvironments will facilitate progenitor cell-mediated skin repair and regeneration.