gebhart/patrepeval huggingface dataset:
Use of DXA-Based Structural Engineering Models of the Proximal Femur to Discriminate Hip Fracture (2008)

Several DXA-based structural engineering models (SEMs) of the proximal femur have been developed to estimate stress caused by sideway falls. Their usefulness in discriminating hip fracture has not yet been established and we therefore evaluated these models. The hip DXA scans of 51 postmenopausal women with hip fracture (30 femoral neck, 17 trochanteric, and 4 unspecified) and 153 age-, height-, and weight-matched controls were reanalyzed using a special version of Hologic's software that produced a pixel-by-pixel BMD map. For each map, a curved-beam, a curved composite-beam, and a finite element model were generated to calculate stress within the bone when falling sideways. An index of fracture risk (IFR) was defined over the femoral neck, trochanter, and total hip as the stress divided by the yield stress at each pixel and averaged over the regions of interest. Hip structure analysis (HSA) was also performed using Hologic APEX analysis software. Hip BMD and almost all parameters derived from HSA and SEM were discriminators of hip fracture on their own because their ORs were significantly >1. Because of the high correlation of total hip BMD to HSA and SEM-derived parameters, only the bone width discriminated hip fracture independently from total hip BMD. Judged by the area under the receiver operating characteristics curve, the trochanteric IFR derived from the finite element model was significant better than total hip BMD alone and similar to the total hip BMD plus bone width in discriminating all hip fracture and femoral neck fracture. No index was better than total hip BMD for discriminating trochanteric fractures. In conclusion, the finite element model has the potential to replace hip BMD in discriminating hip fractures.
Synthetic Aperture Radar Image Statistical Modeling: Part One-Single-Pixel Statistical Models (2020)

With the rapid development of spaceborne synthetic aperture radar (SAR) technology and the acquisition of a large volume of SAR images, SAR image interpretation has become an urgent and difficult research topic. SAR image statistical modeling is one of the theoretical foundations for SAR image interpretation. It is of great value for the in-depth analysis of SAR images. This article reviews the major developments of SAR image statistical modeling since its beginning, including more than 20 statistical distributions of eight statistical models, and gives their derivations and expressions, which can be used as a basic reference for the statistical modeling of SAR images (see "Notations and Definitions").
A Memory Efficient Lock-Free Circular Queue (2021)

Hardware queues are import in many applications, such as data transfer, synchronization of concurrent modules with the need of mutual exclusion constructs. State of the art bounded (of a fixed size) lock free circular queues are implemented either by read/write atomic operations, or barrier conditions, or by separating dequeue and enqueue operations. However, these queues always require an unused element at all the times to safeguard the front and rear pointers of the queue, so as to avoid data race conditions, which leads to the waste of memory. The waste of memory is especially disadvantageous in applications such as I/O data transfer, and image transfer between processing filters, when large element size is needed, We propose a lock- free solution of the bounded circular queue through read/write atomic operations, but without the need of an extra element in the queue. The proposed solution is implemented and verified in both Verilog and 'C' languages. We also demonstrate its effectiveness by comparing its area and delay metrics with the implementations of other existing designs of queue.
Compact dictionaries for diagnosis of unmodeled faults in scan-BIST (2004)

We address the problem of generating compact dictionaries for the diagnosis of unmodeled faults in scan-BIST. We present dictionary organization schemes that provide two orders of magnitude reduction in dictionary size with no significant loss in resolution, and facilitate the diagnosis of unmodeled faults. Experimental results for the ISCAS-89 benchmark circuits show that various types of unmodeled faults can be efficiently located using compact dictionaries generated for single stuck-at-faults.
A General Method for the Suzuki−Miyaura Cross-Coupling of Sterically Hindered Aryl Chlorides:  Synthesis of Di- and Tri-ortho-substituted Biaryls in 2-Propanol at Room Temperature (2003)

The catalytic formation of di- and trisubstituted ortho biaryl junctions has been achieved using a palladacylce pre-catalyst bearing a N-heterocyclic carbene ligand. This transformation is performed at room temperature in technical grade 2-propanol.
Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis (1997)

Rheumatoid arthritis (RA) is characterised by pain and tenderness not only over inflamed or damaged joints, but also over apparently normal tissues. Experimental models suggest that these features results from changes of sensitivity within both peripheral and central neurones, but direct evidence from human disease is lacking. At present, most clinical studies have evaluated overall pain experience rather than activity within components of the nociceptive pathway. Therefore, the aim of this study was to assess the use of a capsaicin-based technique to quantify changes of neuronal sensitivity in patients with RA. First 20 microliters of capsaicin in solution (0.03 mg/ml) was applied topically for 30 min to apparently normal skin on the forearm of control subjects and patients with RA. The subsequent development of mechanical hyperalgesia to pinprick stimuli was then measured at various time points using a 74.4-mN von Frey hair. The relationship between the area of hyperalgesia and a number of clinical measures was determined. Capsaicin-induced mechanical hyperalgesia was found to decline with age in normal subjects (r = 0.47, P < 0.01). The development of hypearlgesia had a similar time course in normal subjects and patients with RA. The maximum area of hyperalgesia, however, was substantially larger in 35 RA patients; 254.3 +/- 20.7 cm2, compared with 35 normal controls; 109 +/- 7.5 cm2 (P < 0.001). An association was apparent between hyperalgesic area and a composite score of joint tenderness (r = 0.47, P < 0.01), but not with overall pain score or a systemic marker of inflammation. These results provide evidence for enhanced sensitisation of a population of sensory fibres in RA. Peripheral sensory activity over the forearms of rheumatoid patients has previously been shown to be normal and the results suggest the presence of enhanced central mechanisms in this disorder. The correlation between capsaicin-induced hyperalgesia and joint tenderness in the RA patients implies that joint symptoms arise partially as a result of central, and not exclusively peripheral, factors. The study supports the use of capsaicin-based techniques to explore nociceptive mechanisms in clinical disorders characterised by chronic pain.
Live Attenuated Influenza Vaccine Provides Superior Protection from Heterologous Infection in Pigs with Maternal Antibodies without Inducing Vaccine-Associated Enhanced Respiratory Disease (2012)

Control of swine influenza A virus (IAV) in the United States is hindered because inactivated vaccines do not provide robust cross-protection against the multiple antigenic variants cocirculating in the field. Vaccine efficacy can be limited further for vaccines administered to young pigs that possess maternally derived immunity. We previously demonstrated that a recombinant A/sw/Texas/4199-2/1998 (TX98) (H3N2) virus expressing a truncated NS1 protein is attenuated in swine and has potential for use as an intranasal live attenuated influenza virus (LAIV) vaccine. In the present study, we compared 1 dose of intranasal LAIV with 2 intramuscular doses of TX98 whole inactivated virus (WIV) with adjuvant in weanling pigs with and without TX98-specific maternally derived antibodies (MDA). Pigs were subsequently challenged with wild-type homologous TX98 H3N2 virus or with an antigenic variant, A/sw/Colorado/23619/1999 (CO99) (H3N2). In the absence of MDA, both vaccines protected against homologous TX98 and heterologous CO99 shedding, although the LAIV elicited lower hemagglutination inhibition (HI) antibody titers in serum. The efficacy of both vaccines was reduced by the presence of MDA; however, WIV vaccination of MDA-positive pigs led to dramatically enhanced pneumonia following heterologous challenge, a phenomenon known as vaccine-associated enhanced respiratory disease (VAERD). A single dose of LAIV administered to MDA-positive pigs still provided partial protection from CO99 and may be a safer vaccine for young pigs under field conditions, where dams are routinely vaccinated and diverse IAV strains are in circulation. These results have implications not only for pigs but also for other influenza virus host species.
Capturing the genetic makeup of the active microbiome <i>in situ</i> (2017)

More than any other technology, nucleic acid sequencing has enabled microbial ecology studies to be complemented with the data volumes necessary to capture the extent of microbial diversity and dynamics in a wide range of environments. In order to truly understand and predict environmental processes, however, the distinction between active, inactive and dead microbial cells is critical. Also, experimental designs need to be sensitive toward varying population complexity and activity, and temporal as well as spatial scales of process rates. There are a number of approaches, including single-cell techniques, which were designed to study in situ microbial activity and that have been successively coupled to nucleic acid sequencing. The exciting new discoveries regarding in situ microbial activity provide evidence that future microbial ecology studies will indispensably rely on techniques that specifically capture members of the microbiome active in the environment. Herein, we review those currently used activity-based approaches that can be directly linked to shotgun nucleic acid sequencing, evaluate their relevance to ecology studies, and discuss future directions.
Atomspektrometrie in der industriellen Praxis (2004)

Abstract Viele unterschiedliche Proben, ein breites Spektrum an Matrizes und der Zwang zur Automatisierung bestimmen die apparative Ausstattung der Atomspektrometrie im Kompetenzzentrum Analytik der BASF. magnified image
Synthesis of [<sup>2</sup>H<sub>3</sub>]‐dextromethorphan and its major urinary metabolites [<sup>2</sup>H<sub>3</sub>]‐dextrorphan and [<sup>2</sup>H<sub>3</sub>]‐dextrorphan‐<i>β</i>‐glucuronide (2002)

Abstract Starting from dextromethorphan, [ 2 H 3 ]‐dextrorphan‐ β ‐glucuronide was synthesized in four steps with [ 2 H 3 ]‐dextromethorphan and [ 2 H 3 ]‐dextrorphan as intermediates with an overall yield of 11%. Copyright © 2002 John Wiley & Sons, Ltd.
Online Multi-Object Tracking and Segmentation with GMPHD Filter and Simple Affinity Fusion (2020)

In this paper, we propose a highly practical fully online multi-object tracking and segmentation (MOTS) method that uses instance segmentation results as an input. The proposed method is based on the Gaussian mixture probability hypothesis density (GMPHD) filter, a hierarchical data association (HDA), and a mask-based affinity fusion (MAF) model to achieve high-performance online tracking. The HDA consists of two associations: segment-to-track and track-to-track associations. One affinity, for position and motion, is computed by using the GMPHD filter, and the other affinity, for appearance is computed by using the responses from a single object tracker such as a kernalized correlation filter. These two affinities are simply fused by using a score-level fusion method such as min-max normalization referred to as MAF. In addition, to reduce the number of false positive segments, we adopt mask IoU-based merging (mask merging). The proposed MOTS framework with the key modules: HDA, MAF, and mask merging, is easily extensible to simultaneously track multiple types of objects with CPU only execution in parallel processing. In addition, the developed framework only requires simple parameter tuning unlike many existing MOTS methods that need intensive hyperparameter optimization. In the experiments on the two popular MOTS datasets, the key modules show some improvements. For instance, ID-switch decreases by more than half compared to a baseline method in the training sets. In conclusion, our tracker achieves state-of-the-art MOTS performance in the test sets.
Maltophilin: A New Antifungal Compound Produced by Stenotrophomonas maltophilia R3089. (1996)

Strains of Stenotrophomonas maltophilia R3089, isolated from the rhizosphere of rape plants (Brassica napus L.), produced a novel antifungal compound, named maltophilin, which inhibited the growth of various saprophytic, human-pathogenic and phytopathogenic fungi but was inactive against Gram-positive and Gram-negative bacteria. Maltophilin is a novel macrocyclic lactam antibiotic with a molecular mass of 510 mu. The compound was isolated from the culture filtrate by ethyl acetate extraction and gel filtration on Sephadex LH20 and purified by preparative HPLC on reversed phase. The structure of maltophilin was elucidated by electrospray mass spectrometry and 1H and 13C NMR spectroscopy.
Microwave Packaging for Superconducting Qubits (2019)

Over the past two decades, the performance of superconducting quantum circuits has tremendously improved. The progress of superconducting qubits enabled a new industry branch to emerge from global technology enterprises to quantum computing startups. Here, an overview of superconducting quantum circuit microwave control is presented. Furthermore, we discuss one of the persistent engineering challenges in the field—how to control the electromagnetic environment of increasingly complex superconducting circuits such that they are simultaneously protected and efficiently controllable.
A block adaptive predistortion algorithm for transceivers with long transmit-receive latency (2010)

The purpose of this paper is to introduce digital predistortion and propose a new digital predistortion scheme for use in systems with lengthy transmit-receive delays. The introduction discusses the motivation to implement digital predistortion within a wireless transceiver system. Then, we introduce techniques commonly found in the literature and the assumptions made in their operation. Finally, a new scheme is proposed which allows consideration of multiple measurements of actual data between predistorter updates. This is beneficial when there is a significant latency after each update before new results can be measured. This new scheme utilizes a block least-mean-squares algorithm, running within a gain-based look-up-table predistorter. The proposed scheme demonstrates a reduction in the time required for power amplifier linearization.
Concentration of black liquor to high solids (1991)

L'evaporation d'eau d'une couche mince (film) de la liqueur noire a ete etudiee en utilisant l'injection par jet; d'air chaud ou de la vapeur. L'epaisseur du film est variee entre 0.8 et 1.2 mm et la temperature du sechage est echelonnee de 180 a 250$ sp circ$C. Autres parametres ont ete etudies; le pourcentage du solide dans la liqueur noire (60-74%) et le debit du fluide du sechage (0.8-1.0 kg/s m$ sp2$).
Modulation of Muscle Tone and Sympathovagal Balance in Cervical Dystonia Using Percutaneous Stimulation of the Auricular Vagus Nerve (2015)

Primary cervical dystonia is characterized by abnormal, involuntary, and sustained contractions of cervical muscles. Current ways of treatment focus on alleviating symptomatic muscle activity. Besides pharmacological treatment, in severe cases patients may receive neuromodulative intervention such as deep brain stimulation. However, these (highly invasive) methods have some major drawbacks. For the first time, percutaneous auricular vagus nerve stimulation (pVNS) was applied in a single case of primary cervical dystonia. Auricular vagus nerve stimulation was already shown to modulate the (autonomous) sympathovagal balance of the body and proved to be an effective treatment in acute and chronic pain, epilepsy, as well as major depression. pVNS effects on cervical dystonia may be hypothesized to rely upon: (i) the alteration of sensory input to the brain, which affects structures involved in the genesis of motoric and nonmotoric dystonic symptoms; and (ii) the alteration of the sympathovagal balance with a sustained impact on involuntary movement control, pain, quality of sleep, and general well-being. The presented data provide experimental evidence that pVNS may be a new alternative and minimally invasive treatment in primary cervical dystonia. One female patient (age 50 years) suffering from therapy refractory cervical dystonia was treated with pVNS over 20 months. Significant improvement in muscle pain, dystonic symptoms, and autonomic regulation as well as a subjective improvement in motility, sleep, and mood were achieved. A subjective improvement in pain recorded by visual analog scale ratings (0-10) was observed from 5.42 to 3.92 (medians). Muscle tone of the mainly affected left and right trapezius muscle in supine position was favorably reduced by about 96%. Significant reduction of muscle tone was also achieved in sitting and standing positions of the patient. Habituation to stimulation leading to reduced stimulation efficiency was observed and counteracted by varying stimulation patterns. Experimental evidence is provided for significantly varied sympathovagal modulation in response to pVNS during sleep, assessed via heart rate variability (HRV). Time domain measures like the root mean square of successive normal to normal heart beat intervals, representing parasympathetic (vagal) activity, increased from 37.8 to 67.6 ms (medians). Spectral domain measures of HRV also show a shift to a more pronounced parasympathetic activity.
Ripple Thermostat (2018)

Force feedback and shape change are modalities with a growing application potential beyond the more traditional GUIs. We present two studies that explored the effect of these modalities on the emotional experience when interacting with an intelligent thermostat. The first study compared visual feedback, force feedback, and a combination of force feedback and shape change. Results indicate that force feedback correlates to experienced dominance during interaction, while shape change mainly affects experienced arousal. The second study explored how force feedback and shape change could communicate affective meaning during interaction with the thermostat through a co-design study. Participants designed the thermostat behavior for three scenarios supporting energy savings. Results suggest that despite their abstractness, force feedback and shape change convey affective meaning during the user-system dialogue. The findings contribute to the design of intelligible and intuitive feedback.
Non‐high‐density lipoprotein cholesterol: An important predictor of stroke and diabetes‐related mortality in Japanese elderly diabetic patients (2012)

Higher non-high-density lipoprotein cholesterol was associated with an increased risk of stroke, diabetes-related mortality and total events in elderly diabetes patients.
Electronic and Conformational Effects in the Photochemistry of .alpha.-Alkenyl-Substituted Vinyl Halides (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic and Conformational Effects in the Photochemistry of .alpha.-Alkenyl-Substituted Vinyl HalidesErik S. Krijnen, Han Zuilhof, and Gerrit LodderCite this: J. Org. Chem. 1994, 59, 26, 8139–8150Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jo00105a035https://doi.org/10.1021/jo00105a035research-articleACS PublicationsRequest reuse permissionsArticle Views464Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Toxic effects of silver-silver chloride electrodes on vascular smooth muscle. (1983)

We found that silver, either as silver metal or silver chloride, exerted toxic effects on the smooth muscle of isolated cannulated hamster cheek pouch arterioles. Silver initially stimulated the smooth muscle, producing a marked vasoconstriction. The vessels then dilated back to control diameters. Once the arterioles began to dilate, they became refractory to norepinephrine or potassium stimulation. We caution the use of silver in the presence of smooth muscle, especially when tissue mass is small or free protein concentration is low.
Moving Droplets in 3D Using Light (2018)

The emulation of the complex cellular and bacterial vesicles used to transport materials through fluids has the potential to add revolutionary capabilities to fluidic platforms. Although a number of artificial motile vesicles or microdroplets have been demonstrated previously, control over their movement in liquid in 3D has not been achieved. Here it is shown that by adding a chemical "fuel," a photoactive material, to the droplet, it can be moved in any direction (3D) in water using simple light sources without the need for additives in the water. The droplets can be made up of a range of solvents and move with speeds as high as 10.4 mm s<sup>-1</sup> toward or away from the irradiation source as a result of a light-induced isothermal change in interfacial tension (Marangoni flow). It is further demonstrated that more complex functions can be accomplished by merging a photoactive droplet with a droplet carrying a "cargo" and moving the new larger droplet to a "reactor" droplet where the cargo undergoes a chemical reaction. The control and versatility of this light-activated, motile droplet system will open up new possibilities for fluidic chemical transport and applications.
A new method for significance map decoding acceleration in the CABAD regular hardware engine (2009)

The design of a hardware accelerator dedicated to Binary Arithmetic Engine (BADE) is presented. This is the main module of the Context-Adaptive Binary Arithmetic Decoder (CABAD), as used in the H.264/AVC on-chip video decoders. We propose and implement a new approach for accelerating the decoding hardware of the significance map by providing the correct context for the regular hardware engine of the (CABAD). The design development was based on a large set of software experiments, which aimed at exploiting the characteristic behavior of the bitstream during decoding. The analysis gave new insights to propose a new hardware architecture to improve throughput of regular engines for significance map with low silicon area overhead. The proposed solution was described in VHDL and synthesized to standard cells in IBM 0.18 μm CMOS process. The results show that the developed architecture reaches 187 MHz with a non optimized physical synthesis.