gebhart/patrepeval huggingface dataset:
TETRA DIIIC: A NOVEL VACCINE CANDIDATE AGAINST DENGUE (2014)

Introduction : It is estimated that nearly half of the world’s population is at risk of infection with dengue virus, with up to 50 million people infected each year and frequent epidemic activity in Southeast Asia, South America and Western Pacific regions. Our group has developed a subunit vaccine candidate against dengue based on two different viral regions: the domain III of the envelope (E) protein and the capsid protein. In the present work, a summary of results obtained with this vaccine candidate, is presented. Materials and methods : Mice and monkeys experiments were carried out to characterize the immune response generated with the monovalent and tetravalent formulations containing the four recombinant proteins DIIICs. The main markers tested were neutralizing antibodies, cell-mediated immunity and protection against viral challenge in the two animal models. Results : The novel chimeric protein from dengue-2 virus (domain III-capsid (DIIIC-2)), when presented as particulate aggregated incorporating oligodeoxynucleotides, induced antiviral and neutralizing antibodies, cellular immune response, and conferred significant protection to mice and monkeys. Furthermore, the rest of constructs were obtained and proper characterized. In the mice experiment it was demonstrated the immunogenicity of each protein in terms of humoral and cell-mediated immunity. In addition, significant protection was afforded as measured by the limited viral load in the immunized animals. Finally, upon monkey immunization with the tetravalent formulation, it was demonstrated that 100% of the animals were positive by neutralizing antibodies and CMI, regardless the route of immunization used. Conclusions : Taken together we can assert that tetra DIIIC constitutes a promising vaccine candidate against the four dengue serotypes, and propose it for the further efficacy experiments in NHP against the four dengue serotypes.
Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab (2018)

Human epidermal growth factor receptor type 3 (HER3) is recognized to be involved in resistance to HER-targeting therapies. A number of HER3-targeting monoclonal antibodies are under clinical investigation as potential cancer therapeutics. Smaller high-affinity scaffold proteins are attractive non-Fc containing alternatives to antibodies. A previous study indicated that anti-HER3 affibody molecules could delay the growth of xenografted HER3-positive tumors. Here, we designed a second-generation HER3-targeting construct (TAM-HER3), containing two HER3-specific affibody molecules bridged by an albumin-binding domain (ABD) for extension of blood circulation. Receptor blocking activity was demonstrated in vitro. In mice bearing BxPC-3 xenografts, the therapeutic efficacy of TAM-HER3 was compared to the HER3-specific monoclonal antibody seribantumab (MM-121). TAM-HER3 inhibited heregulin-induced phosphorylation in a panel of HER3-expressing cancer cells and was found to be equally as potent as seribantumab in terms of therapeutic efficacy in vivo and with a similar safety profile. Median survival times were 60 days for TAM-HER3, 54 days for seribantumab, and 41 days for the control group. No pathological changes were observed in cytopathological examination. The multimeric HER3-binding affibody molecule in fusion to ABD seems promising for further evaluation as candidate therapeutics for treatment of HER3-overexpressing tumors.
Structure-activity relationships of sparsomycin and its analogs. Inhibition of peptide bond formation in cell-free systems and of L1210 and bacterial cell growth (1987)

The biological activity of 14 analogues of sparsomycin (1) was studied in cell-free systems of Escherichia coli, Saccharomyces cerevisiae, and Sulfolobus solfataricus by measuring the inhibition of protein synthesis. The inhibition of L1210 colony formation in soft agar and bacterial cell growth in solid as well as in liquid medium was also examined. Each analogue possesses not more than two structural modifications of the sparsomycin molecule. This enabled us to determine unambiguously several structural and stereochemical features that are required for an optimal biological activity in these assays. Sparsomycin, having the SCRS chirality, is the most potent of the four possible stereoisomers. The results obtained with compounds 5-7 indicate that the presence of an oxygen atom on the S (alpha) atom is essential. Substitution of the bivalent sulfur atom by a CH2 group (10) or of the SCH3 moiety by a Cl atom (12) affects the activity of the molecule partially. Compound 12 is surprisingly active against intact cells. Substitution of the C(6)-CH3 group by a H(14) reduces the activity of the molecule. Isomerization of the trans double bond into the cis double bond yields cis-sparsomycin (15), which is inactive. The hydrophobic derivatives 8, 9, and 11 are considerably more active than sparsomycin; thus the ribosomal binding site for sparsomycin may have a hydrophobic character.
A TE-TM mode splitter on lithium niobate using Ti, Ni, and MgO diffusions (1994)

A new TE-TM mode splitter with an asymmetric Y-junction structure fabricated by diffusing different materials into Y-cut lithium niobate is presented. Randomly polarized light launched into a titanium indiffused waveguide is split into TE and TM modes by two different single-polarization waveguides. The ordinary-polarized waveguide is made by nickel indiffusion and the extraordinary-polarized waveguide by magnesium-oxide induced lithium outdiffusion. The measured extinction ratios are greater than 20 dB for both TE and TM modes. The devices operate over a wide wavelength range and have a large fabrication tolerance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Controlling surface enhanced Raman scattering using grating-type patterned nanoporous gold substrates (2013)

We investigate the effect of grating design on surface enhanced Raman scattering (SERS) intensity using patterned nanoporous gold (P-NPG) films. The SERS response is systematically engineered by tuning the parameters of gratings imprinted on the nanoporous gold films, including grating period, duty cycle, and height. Compared to conventional NPG films, where the localized surface plasmon dominates the strong SERS response, the significantly enhanced SERS response from our P-NPG structures primarily arises from efficient activation of a surface plasmon polariton and its coupling with the localized surface plasmon mode. The P-NPG SERS substrates exhibit large area uniform enhancement factors near 108.
A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana (1995)

Genetic analysis of virus detected in autopsy tissues of a fatal hantavirus pulmonary syndrome-like case in Louisiana revealed the presence of a previously unrecognized hantavirus. Nucleotide sequence analysis of PCR fragments of the complete S and M segments of the virus amplified from RNA extracted from the tissues showed the virus to be novel, differing from the closest related hantavirus, Sin Nombre virus, by approximately 30%. Both genome segments were unique, and there was no evidence of genetic reassortment with previously characterized hantaviruses. The primary rodent reservoir of Sin Nombre virus, the deer mouse Peromyscus maniculatus, is absent from Louisiana. Thus, the virus detected in Louisiana, referred to here as Bayou virus, must possess a different rodent reservoir.
Tunable dual-band graphene-based infrared reflectance filter (2018)

We experimentally demonstrated an actively tunable optical filter that controls the amplitude of reflected long-wave-infrared light in two separate spectral regions concurrently. Our device exploits the dependence of the excitation energy of plasmons in a continuous and unpatterned sheet of graphene on the Fermi-level, which can be controlled via conventional electrostatic gating. The filter enables simultaneous modification of two distinct spectral bands whose positions are dictated by the device geometry and graphene plasmon dispersion. Within these bands, the reflected amplitude can be varied by over 15% and resonance positions can be shifted by over 90 cm<sup>-1</sup>. Electromagnetic simulations verify that tuning arises through coupling of incident light to graphene plasmons by a grating structure. Importantly, the tunable range is determined by a combination of graphene properties, device structure, and the surrounding dielectrics, which dictate the plasmon dispersion. Thus, the underlying design shown here is applicable across a broad range of infrared frequencies.
Laser Performance and Spectroscopy of Cr3+ in LiCaAlF6 and LiSrAlF6 (1989)

We comprehensively report on the laser measurements and relevant spectroscopic properties of the materials LiCaAlF6:Cr3+ (Cr:L1CAF) and L1SrAlF6:Cr3+ (Cr:LiSAF). Laser-pumped laser measurements show that slope efficiencies of >50% are attainable with currently available Cr:LiCAF material, and that efficiencies of 67% should ultimately be achievable. Efficiencies of 36% have been measured for Cr:LiSAF. The absorption and emission properties, and the direct measurements of the excited state absorption loss, support the data concerning the lasing efficiencies and tuning ranges. Flashlamp-pumped operation of Cr:LiCAF has provided electrical efficiencies of 1.55% thus far, and we expect to obtain performance comparable to that of alexandrite in the future (which is 4% efficiency 1n the present apparatus).
Capsule switching of <i>Neisseria meningitidis</i> (1997)

The different sialic acid (serogroups B, C, Y, and W-135) and nonsialic acid (serogroup A) capsular polysaccharides expressed by Neisseria meningitidis are major virulence factors and are used as epidemiologic markers and vaccine targets. However, the identification of meningococcal isolates with similar genetic markers but expressing different capsular polysaccharides suggests that meningococcal clones can switch the type of capsule they express. We identified, except for capsule, isogenic serogroups B [(alpha2-->8)-linked polysialic acid] and C [(alpha2-->9)-linked polysialic acid] meningococcal isolates from an outbreak of meningococcal disease in the U. S. Pacific Northwest. We used these isolates and prototype serogroup A, B, C, Y, and W-135 strains to define the capsular biosynthetic and transport operons of the major meningococcal serogroups and to show that switching from the B to C capsule in the outbreak strain was the result of allelic exchange of the polysialyltransferase. Capsule switching was probably the result of transformation and horizontal DNA exchange in vivo of a serogroup C capsule biosynthetic operon. These findings indicate that closely related virulent meningococcal clones may not be recognized by traditional serogroup-based surveillance and can escape vaccine-induced or natural protective immunity by capsule switching. Capsule switching may be an important virulence mechanism of meningococci and other encapsulated bacterial pathogens. As vaccine development progresses and broader immunization with capsular polysaccharide conjugate vaccines becomes a reality, the ability to switch capsular types may have important implications for the impact of these vaccines.
ChemInform Abstract: The Lithium/Air Battery: Still an Emerging System or a Practical Reality? (2015)

Abstract Review: 218 refs.
Emerging spectrum regulation for Medical Body Area Network (2013)

Medical Body Area Network (MBAN) technology is a promising solution to improve patient care outcomes and lower healthcare costs. To foster MBAN innovations, the FCC recently allocated dedicated spectrum for MBAN services. In this paper, we present a brief summary of the FCC MBAN rules. Then, we discuss the technical rationale for the selection of key parameters, such as frequency band selection, emission bandwidth limit, and transmission power limit. Finally, we provide link budget analysis and MBAN coexistence simulations to demonstrate that the FCC rules can meet the requirements of MBAN applications.
Representation Learning in Large Attributed Graphs. (2017)

Graphs (networks) are ubiquitous and allow us to model entities (nodes) and the dependencies (edges) between them. Learning a useful feature representation from graph data lies at the heart and success of many machine learning tasks such as classification, anomaly detection, link prediction, among many others. Many existing techniques use random walks as a basis for learning features or estimating the parameters of a graph model for a downstream prediction task. Examples include recent node embedding methods such as DeepWalk, node2vec, as well as graph-based deep learning algorithms. However, the simple random walk used by these methods is fundamentally tied to the identity of the node. This has three main disadvantages. First, these approaches are inherently transductive and do not generalize to unseen nodes and other graphs. Second, they are not space-efficient as a feature vector is learned for each node which is impractical for large graphs. Third, most of these approaches lack support for attributed graphs. 
To make these methods more generally applicable, we propose a framework based on the notion of attributed random walk that is not tied to node identity and is instead based on learning a function $\Phi : \mathrm{\rm \bf x} \rightarrow w$ that maps a node attribute vector $\mathrm{\rm \bf x}$ to a type $w$. This framework serves as a basis for generalizing existing methods such as DeepWalk, node2vec, and many other previous methods that leverage traditional random walks.
Quantum dot comb-laser as efficient light source for silicon photonics (2008)

We report on edge-emitting InAs/GaAs quantum dot laser promising as multiple wavelength light source for dense wavelength-division-multiplexing systems in future generation of silicon photonic integrated circuits. Broad and flat gain spectrum of quantum dots as well as pronounced gain saturation effect facilitate simultaneous lasing via a very large number of longitudinal modes with uniform intensity distribution (comb spectrum). A very broad lasing spectrum of about 75 nm in the 1.2-1.28 μm wavelength range with a total output power of 750 mW in single lateral mode regime is achieved by intentional inhomogeneous broadening of ground state transition peak and contribution of lasing via excited state transitions. Average spectral power density exceeds 10 mW/nm. A bit error rate less than 10<sup>-13</sup> is demonstrated for ten spectrally filtered and externally modulated at 10 Gb/s Fabry-Perot modes owing to a low (<0.3% in the 0.001-10 GHz range) relatively intensity noise of each individual mode. This result shows aptitude of a multimode quantum dot laser for high bandwidth wavelength-division-multiplexing systems.
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system (1996)

As a participant of the endogenous arachidonic acid metabolic cascade, microsomal cytochrome P450 metabolizes the fatty acid to biologically active hydroxyeicosatetraenoic and epoxyeicosatrienoic acids. Studies from several laboratories have documented the powerful vasoactive properties of these P450-derived eicosanoids. Associated changes in cell membrane ion permeability and fluxes may provide the molecular basis underlining their vasoactivity. Furthermore, a role for the P450 arachidonic acid monooxygenase in renal physiology and pathophysiology has been suggested by: 1) an association between the activities of the arachidonic acid omega/omega-1 oxygenase and the development of hypertension in spontaneously hypertensive rats, and 2) a relationship between acquired or inherited abnormalities in the renal epoxygenase activities and/or regulation and salt-sensitive hypertension in Dahl rats. These studies provide significant evidence to indicate that microsomal P450, in addition to its recognized traditional toxicological and pharmacological roles, may also play an important physiological role in the control of tissue and body homeostasis.
RRED Indices: Reduced Reference Entropic Differencing for Image Quality Assessment (2011)

We study the problem of automatic "reduced-reference" image quality assessment (QA) algorithms from the point of view of image information change. Such changes are measured between the reference- and natural-image approximations of the distorted image. Algorithms that measure differences between the entropies of wavelet coefficients of reference and distorted images, as perceived by humans, are designed. The algorithms differ in the data on which the entropy difference is calculated and on the amount of information from the reference that is required for quality computation, ranging from almost full information to almost no information from the reference. A special case of these is algorithms that require just a single number from the reference for QA. The algorithms are shown to correlate very well with subjective quality scores, as demonstrated on the Laboratory for Image and Video Engineering Image Quality Assessment Database and the Tampere Image Database. Performance degradation, as the amount of information is reduced, is also studied.
A High-Density 45nm SRAM Using Small-Signal Non-Strobed Regenerative Sensing (2008)

In this work, an SRAM in low-power 45nm CMOS is composed of 0.25mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> bit-cells and uses an offset-compensating non-strobed regenerative sense-amplifier (NSR-SA); this eliminates the need to insert timing margin for variation and tracking errors in the strobe signal, and it achieves higher sensitivity than conventional SAs, allowing read SNM to be optimized at the cost of I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">READ</sub> . The NSR-SA uses nearly minimum-sized inverters, so its delay and area scaling follow logic trends more closely than conventional SAs.
Negative electrode for lead--acid storage battery. [fabrication] (1978)

A negative lead--acid storage battery electrode has a base made of a porous, sintered metal lighter than lead infiltrated with lead, lead alloy, or a metal wetted by pure lead in the molten state. The base is then provided with a protective layer of pure lead and negative active mass atop the pure lead layer. 1 figure, 2 tables.
New enzyme membrane for enzyme electrodes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew enzyme membrane for enzyme electrodesRuth. Tor and Amihay. FreemanCite this: Anal. Chem. 1986, 58, 6, 1042–1046Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/ac00297a013https://doi.org/10.1021/ac00297a013research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Towards a six-state magnetic memory element (2016)

We pattern permalloy films into three crossing elongated ellipses with an angle of 60° between the major axes of any pair of ellipses. Planar Hall effect measurements show that the magnetization in the area of overlap of the ellipses has six stable magnetic orientations parallel to the major axes of the three ellipses. We determine the effective anisotropy field for small magnetic deviations from the easy axis and the switching field between the easy axes as a function of magnetic field orientation. We compare our results with micromagnetic simulations and present an effective Hamiltonian that captures the magnetic response. We show how such magnetic structures in a magnetic tunnel junction would result in a magnetic memory element with six distinct resistance states that could be written using spin-orbit torques.
Supramolecular polymers: from scientific curiosity to technological reality (2003)

Abstract Supramolecular polymers [1] are introduced as a new approach to come to materials in which the repeating units are not connected by covalent bonds but by specific secondary interactions. Self‐complementary quadruple hydrogen bonded structures with high association constants are presented as easy to synthesize fragments in supramolecular polymers. Some of the many possibilities of equilibrium polymers are discussed, while it is shown that these supramolecular polymers can obtain materials properties normally only obtained with macromolecules.
Stabilized Alkali-Metal Ultraviolet-Band-Pass Filters (1995)

Layers of bismuth 5 to 10 angstrom thick incorporated into alkali-metal ultraviolet-band-pass optical filters by use of advanced fabrication techniques. In new filters layer of bismuth helps to reduce surface migration of sodium. Sodium layer made more stable and decreased tendency to form pinholes by migration.
[Hyp3]Met-callatostatin. Identification and biological properties of a novel neuropeptide from the blowfly Calliphora vomitoria. (1994)

A novel, hydroxyproline-containing neuropeptide, Gly-Pro-Hyp-Tyr-Asp-Phe-Gly-Met-NH2, designated [HYP3]Met-callatostatin, has been identified from extracts of heads of the blowfly Calliphora vomitoria. The peptide is a naturally occurring hydroxylate analogue of Met-callatostatin, a previously identified allatostatin-like peptide, and is present to the extent of 20% of the nonhydroxylated form. In bioassays, both forms of the peptide show allatostatic activity by inhibiting juvenile hormone synthesis and release in the cockroaches Periplaneta americana, Diploptera punctata, and Blattella germanica (IC50 = 100 pM-10 nM). They do not, however, influence juvenile hormone bisepoxide synthesis and release in the blowfly. In flies, [Hyp3]Met-callatostatin inhibits the peristaltic movements of the hindgut, showing a biphasic response (IC50 = 0.5 pM and 0.5 microM) compared with the monophasic response of Met-callatostatin (IC50 = 100 nM). Immunocytochemical studies with Met-callatostatin antisera provide the cytological basis for a myoinhibitory role in the gut since the axons of immunoreactive neurons in the abdominal ganglion project to the ileum. There are also endocrine cells in the midgut that, by releasing the peptides into the hemolymph, would allow the Met-callatostatins to fulfill a neurohormonal role on muscles of the gut and heart. In contrast, there are no Met-callatostatin neural pathways from the brain to the corpus allatum, the gland that produces juvenile hormone. NH2-terminal degradation of Met-callatostatins incubated with the hemolymph of P. americana results in cleavage of the Pro-Tyr bond giving the pentapeptide Tyr-Asp-Phe-Gly-Met-NH2 as a degradation product. In contrast, the Hyp-Tyr bond resists cleavage. With hemolymph from C. vomitoria, no immunoassayable degradation product has been observed with either peptide.