gebhart/patrepeval huggingface dataset:
Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant (2003)

Several contact allergens are tested at concentrations which might cause irritant reactions. In this study we investigated whether the reactivity to a standard irritant is useful in identifying subjects with hyperreactive skin yielding a higher rate of doubtful or irritant reactions. Sodium lauryl sulfate (SLS) 0.5% (aqua) was tested in addition to the standard series routinely for 5 years in the Department of Dermatology, Dortmund. For data analysis, we compared reactions at D3 to the standard series, the vehicle/emulsifier and preservative series and benzoyl peroxide to the reactions obtained with SLS. Proportions were standardized for age and sex. The association between reactivity to a certain allergen and SLS reactivity as a dichotomous outcome, controlled for age and sex as potential confounders, was assessed with logistic regression analysis. Results showed that of the 1600 tested patients, 668 (41.8%) had an irritant reaction to SLS which exceeded 2 + in only 41 patients. Seasonal variation was statistically significant, showing reduced SLS reactivity in summer vs. winter. Patients with irritant reactions to SLS showed significantly more erythematous reactions to the following 10 allergens of the standard series: fragrance mix, cobalt chloride, balsam of Peru (Myroxylon pereirae), lanolin alcohol, 4-phenylenediamine base (PPD), propolis, formaldehyde, N-isopropyl-N'-phenyl-p-phenylenediamine (IPPD), benzocaine, and 4-tert-butylphenol-formaldehyde resin. No significant differences regarding strong positive allergic reactions were observed. Concerning other allergens, significantly more erythematous reactions were observed in SLS-reactive patients to benzoyl peroxide, octyl gallate, cocamidopropyl betaine, Amerchol L-101, tert-butylhydroquinone, and triethanolamine. In the SLS-reactive group of patients, the reaction index was negative for 10 allergens of the standard series compared to only 5 in the SLS non-responder group. For the first time, this study, based on a large data pool, revealed a significant association between reactivity to the irritant SLS and erythematous reactions to certain allergens. With SLS as a marker for hyperreactive skin at hand, some of these reactions can now be classified as irritant more confidently, particularly if there is no history of exposure to the allergen.
Coaxial optical coupler (1982)

An optical coaxial dielectric directional coupler is described. The results of numerical calculations are given for the design of phase matched guides, beat lengths, fabrication tolerances and switching sensitivities.
Preliminary evaluation of the cytotoxic and genotoxic potential of D‐003: Mixture of very long chain fatty acids (2002)

D-003 is a mixture of very long chain aliphatic acids purified from sugar cane wax, wherein octacosanoic acid represents the major component. Previous experimental studies have shown that D-003 inhibits platelet aggregation in rodents. Also, its lowers total (TC) and low-density lipoprotein cholesterol (LDL-C) in normocholesterolemic rabbits in a dose-dependent manner and inhibits cholesterol biosynthesis in fibroblast cultures. The present study was performed to investigate the in vitro cytotoxic and genotoxic potential effects of D-003 assessed through two tests: the neutral red (NR) assay and the Ames test. Positive and negative controls were included in each experimental series. Compared with controls, no cytotoxicity was evident after 24 and 72 h of treatment with doses up to 1,000 microg/ml in the NR assay. On the other hand, D-003 (5-5,000 microg/plate) did not increase the frequency of reverse mutations in the Ames test in both alternatives with or without S9 mix metabolic activation and a pre-incubation step. The positive control chemicals included in each experiment, namely, treatment with sodium dodecyl sulphate (SDS) in the NR assay and sodium azide (NaAz), 2-aminofluorene (AF), and dimethylnitrosamine (DMNA) in the Ames test, induced the expected changes, such as a decrease in optical density (OD) values in the NR assay and an increase in the frequency of reverse mutations in the Ames test. The present results indicate that D-003 did not show evidence of cytotoxic or genotoxic potential in tests able to detect the ability of chemicals to disrupt cells (NR assay) or to induce gene mutations (Ames test).
Unregulated brain iron deposition in transgenic mice over‐expressing <i><scp>HMOX</scp>1</i> in the astrocytic compartment (2012)

The mechanisms responsible for pathological iron deposition in the aging and degenerating mammalian CNS remain poorly understood. The stress protein, HO-1 mediates the degradation of cellular heme to biliverdin/bilirubin, free iron, and CO and is up-regulated in the brains of persons with Alzheimer's disease and Parkinson's disease. HO-1 induction in primary astroglial cultures promotes deposition of non-transferrin iron, mitochondrial damage and macroautophagy, and predisposes cocultured neuronal elements to oxidative injury. To gain a better appreciation of the role of glial HO-1 in vivo, we probed for aberrant brain iron deposition using Perls' method and dynamic secondary ion mass spectrometry in novel, conditional GFAP.HMOX1 transgenic mice that selectively over-express human HO-1 in the astrocytic compartment. At 48 weeks, the GFAP.HMOX1 mice exhibited increased deposits of glial iron in hippocampus and other subcortical regions without overt changes in iron-regulatory and iron-binding proteins relative to age-matched wild-type animals. Dynamic secondary ion mass spectrometry revealed abundant FeO⁻ signals in the transgenic, but not wild-type, mouse brain that colocalized to degenerate mitochondria and osmiophilic cytoplasmic inclusions (macroautophagy) documented by TEM. Sustained up-regulation of HO-1 in astrocytes promotes pathological brain iron deposition and oxidative mitochondrial damage characteristic of Alzheimer's disease-affected neural tissues. Curtailment of glial HO-1 hyperactivity may limit iron-mediated cytotoxicity in aging and degenerating neural tissues.
Computational Modeling of the Female Pelvic Support Structures and Organs to Understand the Mechanism of Pelvic Organ Prolapse: A Review (2015)

Pelvic organ prolapse (POP) is an abnormality of the female pelvic anatomy due to events, such as multiple child births, menopause, and morbid obesity, which may lead to weakening of the pelvic floor striated muscles and smooth musculo-connective tissues. POP leads to dropping of the pelvic organs, namely, the bladder, uterus, and rectum into the vaginal canal and eventual protrusion, causing vaginal pain, pressure, difficulty emptying the bladder and rectum, and sexual dysfunction. Each year, close to 300,000 POP surgeries are performed in the U.S., out of which more than 60% of patients may face relapse conditions. A closer look into the problem reveals that POP surgery failures may be attributed mainly to the lack of understanding among medical practitioners on the mechanics of prolapse. In the literature, there have been attempts in the engineering community to understand prolapse using phenomenological computational modeling. This paper reviews the development and study of these numerical models, aimed at understanding the mechanics of POP. The various computational challenges related to geometry creation, material modeling, finite-element (FE) modeling, and boundary conditions (BCs) will be discussed and significant future research directions will also be highlighted in this review.
Shape Stability of Octahedral PtNi Nanocatalysts for Electrochemical Oxygen Reduction Reaction Studied by <i>in situ</i> Transmission Electron Microscopy (2018)

Octahedral faceted nanoparticles are highly attractive fuel cell catalysts as a result of their activity for the oxygen reduction reaction (ORR). However, their surface compositional and morphological stability currently limits their long-term performance in real membrane electrode assemblies. Here, we perform in situ heating of compositionally segregated PtNi<sub>1.5</sub> octahedral nanoparticles inside a transmission electron microscope, in order to study their compositional and morphological changes. The starting PtNi<sub>1.5</sub> octahedra have Pt-rich edges and concave Ni-rich {111} facets. We reveal a morphological evolution sequence, which involves transformation from concave octahedra to particles with atomically flat {100} and {111} facets, ideally representing truncated octahedra or cuboctahedra. The flat {100} and {111} facets are thought to comprise a thin Pt layer with a Ni-rich subsurface, which may boost catalytic activity. However, the transformation to truncated octahedra/cuboctahedra also decreases the area of the highly active {111} facets. The morphological and surface compositional evolution, therefore, results in a compromise between catalytic activity and morphological stability. Our findings are important for the design of more stable faceted PtNi nanoparticles with high activities for the ORR.
Age, Viral Copy Number, and Immunosuppressive Therapy Affect the Duration of Norovirus RNA Excretion in Inpatients Diagnosed with Norovirus Infection (2011)

Norovirus is one of the leading causes of acute gastroenteritis worldwide. Although it is becoming clear that viral excretion in the stool continues even after the clinical symptoms have disappeared, the factors that determine its duration remain unknown. Between 2007 and 2009, all inpatients and medical staff at our hospital who showed symptoms of a new onset of gastroenteritis were asked to submit a sample for norovirus testing by real-time RT-PCR. One of the 273 patients included tested positive for GI norovirus, and a further 89 were positive for GII norovirus. Of these 90 norovirus-positive individuals, 76% excreted norovirus RNA in the stool for more than 7 days. The inpatient group contained more long shedders than the medical staff group (5/32 versus 1/39, P<0.05). The median viral shedding duration was 19.3 and 15.2 days for inpatients and medical staff, respectively. Among hospitalized patients, younger individuals, those with a higher viral copy number, and individuals receiving immunosuppressive therapy tended to require a longer time to eliminate the virus. These patients should therefore be monitored and managed carefully to prevent nosocomial spread of the disease.
The Modeling and Assessment of Work Performance (2015)

Individual work role performance drives the entire economy. It is organizational psychology and organizational behavior’s (OP/OB’s) most crucial dependent variable. In this review, alternative specifications for the definition and latent structure of individual performance are reviewed and summarized. Setting aside differences in terminology, the alternatives are remarkably similar. The Campbell (2012) model is offered as a synthesized description of the content of the latent structure. Issues pertaining to performance dynamics are then reviewed, along with the role played by individual adaptability to changing performance requirements. Using the synthesized model of the latent content structure and dynamics of performance as a backdrop, issues pertaining to the assessment of performance are summarized. The alternative goals of performance assessment, general measurement issues, and the construct validity of specific methods (e.g., ratings, simulations) are reviewed and described. Cross-cultural issues and future research needs are noted.
Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells (2012)

Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incubation (29°C) to traffic to the plasma membrane where it functions as a chloride channel. Here we show that, cardiac glycosides, at nanomolar concentrations, can partially correct the trafficking of F508del-CFTR in human CF bronchial epithelial cells (CFBE41o-) and in an F508del-CFTR mouse model. Comparison of the transcriptional profiles obtained with polarized CFBE41o-cells after treatment with ouabain and by low temperature has revealed a striking similarity between the two corrector treatments that is not shared with other correctors. In summary, our study shows a novel function of ouabain and its analogs in the regulation of F508del-CFTR trafficking and suggests that compounds that mimic this low temperature correction of trafficking will provide new avenues for the development of therapeutics for CF.
Materials for Sustained and Controlled Release of Nutrients and Molecules To Support Plant Growth (2011)

Controlled release fertilizers (CRFs) are a branch of materials that are designed to improve the soil release kinetics of chemical fertilizers to address problems stemming losses from runoff or other factors. Current CRFs are used but only in a limited market due to relatively high costs and doubts about their abilities to result in higher yields and increased profitability for agricultural businesses. New technologies are emerging that promise to improve the efficacy of CRFs to add additional functionality and reduce cost to make CRFs a more viable alternative to traditional chemical fertilizer treatment. CRFs that offer ways of reducing air and water pollution from fertilizer treatments, improving the ability of plants to access required nutrients, improving water retention to increase drought resistance, and reducing the amount of fertilizer needed to provide maximum crop yields are under development. A wide variety of different strategies are being considered to tackle this problem, and each approach offers different advantages and drawbacks. Agricultural industries will soon be forced to move toward more efficient and sustainable practices to respond to increasing fertilizer cost and desire for sustainable growing practices. CRFs have the potential to solve many problems in agriculture and help enable this shift while maintaining profitability.
Predictors of Morbidity and Mortality in Neonates with Herpes Simplex Virus Infections (1991)

There were no deaths among the 85 infants with localized HSV infection. The mortality rate was significantly higher in the 46 neonates with disseminated infection (57 percent) than in the 71 with encephalitis (15 percent). In addition, the risk of death was increased in neonates who were in or near coma at entry (relative risk, 5.2), had disseminated intravascular coagulopathy (relative risk, 3.8), or were premature (relative risk, 3.7). In babies with disseminated disease, HSV pneumonitis was also associated with greater mortality (relative risk, 3.6). In the survivors, morbidity was most frequent in infants with encephalitis (relative risk, 4.4), disseminated infection (relative risk, 2.1), seizures (relative risk, 3.0), or infection with HSV type 2 (relative risk, 4.9). With HSV infection limited to the skin, eyes, or mouth, the presence of three or more recurrences of vesicles was associated with an increased risk of neurologic impairment as compared with two or fewer recurrences.
The Effect of Age on Second Language Acquisition in Older Adults (2014)

The Veterans Administration is amending its regulations concerning eligibility for vocational rehabilitation and educational assistance under chapters 31 and 34, title 38, United States Code. These changes are necessary in order to implement a law enacted October 8, 1977. Most of the changes are of a minor technical nature. The regulatory amendments will implement the provisions of the law.
Improved robustness of 3D CT to 2D fluoroscopy image registration using log polar transforms (2016)

Automatic image registration algorithms that rely on a gradient descent based approach may fail when the initial misalignment between objects is large. The registration task is even more difficult for multi-modal images because of the non-linear relationship between the pixel intensities in the images to be aligned. In this paper we will present a multi-modal image registration algorithm which successfully registers 3D CT to 2D fluoroscopy data for large initial displacements between the images. The approach uses the conditional means (CM) of the joint probability distribution of the images to establish a model linear relationship between the pixel intensities of the images and then applies log-polar transforms (LPT) in the frequency domain to estimate the in-plane scale and rotation changes between the images. Our experimental results show that the proposed approach can increase the range of initial displacements for which the algorithm is able successfully register images by a factor of 4 when compared to the best of the existing gradient-descent based approaches.
A multilevel approach to intelligent information filtering (1997)

In information-filtering environments, uncertainties associated with changing interests of the user and the dynamic document stream must be handled efficiently. In this article, a filtering model is proposed that decomposes the overall task into subsystem functionalities and highlights the need for multiple adaptation techniques to cope with uncertainties. A filtering system, SIFTER, has been implemented based on the model, using established techniques in information retrieval and artificial intelligence. These techniques include document representation by a vector-space model, document classification by unsupervised learning, and user modeling by reinforcement learning. The system can filter information based on content and a user's specific interests. The user's interests are automatically learned with only limited user intervention in the form of optional relevance feedback for documents. We also describe experimental studies conducted with SIFTER to filter computer and information science documents collected from the Internet and commercial database services. The experimental results demonstrate that the system performs very well in filtering documents in a realistic problem setting.
Exposure to Nitrous Oxide and Neurologic Disease among Dental Professionals (1981)

Questionnaires, mailed to approximately 30,000 dentists and an equal number of dental assistants requesting information regarding professional exposure to anesthetics and health problems, showed an increased incidence of neurologic complaints in dental professionals who worked with nitrous oxide. The most striking differences were noted in individuals reporting symptoms of numbness, tingling, and/or muscle weakness. For dentists heavily exposed to nitrous oxide, the rate of these complaints was 4-fold greater than for nonanesthetic-exposed dentists. For dental assistants heavily exposed to nitrous oxide, a 3-fold increase in these same complaints was noted. In view of recent evidence that nitrous oxide abuse may lead to polyneuropathy, the results suggest that occupational exposure to nitrous oxide by both dentists and dental assistants may be associated with similar neuropathy.
Probiotic supplementation improves the cognitive function and the anxiety-like behaviors in the stressed rats. (2019)

Our findings confirmed a link between the gut microbiome and probiotics with the behavioral functions and HPA axis. The probiotic treatment favorably affected the stress-dependent behavioral disorders and the interaction between HPA and gut-brain-microbiota axes.
Generation of Variations on Theme Music Based on Impressions of Story ScenesConsidering Human′s Feeling of Music and Stories (2007)

This paper describes a system which generates variations on theme music fitting to story scenes represented by texts and/or pictures. Inputs to the present system are original theme music and numerical information on given story scenes. The present system varies melodies, tempos, tones, tonalities, and accompaniments of given theme music based on impressions of story scenes. Genetic algorithms (GAs) using modular neural network (MNN) models as fitness functions are applied to music generation in order to reflect user′s feeling of music and stories. The present system adjusts MNN models for each user on line. This paper also describes the evaluation experiments to confirm whether the generated variations on theme music reflect impressions of story scenes appropriately or not.
Recent progress in the synthesis of nanostructured magnesium hydroxide (2017)

This highlight discusses magnesium hydroxide design at the nanoscale, common aspects of crystallite growth and how nanostructuring impacts properties.
The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages (2000)

The Yersinia protein tyrosine phosphatase (PTP) YopH is translocated into eukaryotic cells by a type III secretion system that requires bacterial-host cell contact. YopH is composed of two modular effector domains: a substrate-binding domain located in the N-terminal region (residues 1-130) and a PTP catalytic domain located in the C-terminal region (residues 206-468). Previous studies have shown that YopH selectively targets tyrosine-phosphorylated proteins of approximate molecular weight 120 kDa (p120) and 55 kDa (p55) in murine macrophages. It has been demonstrated that p120 actually represents two tyrosine-phosphorylated target proteins, Cas and Fyb. We used the substrate-binding domain of YopH to affinity purify tyrosine-phosphorylated target proteins from lysates of J774A.1 macrophages. Protein microsequencing identified p55 as murine SKAP-HOM. Direct interaction between SKAP-HOM and a catalytically inactive form of YopH was demonstrated in vitro and in macrophages. In addition, we obtained evidence that SKAP-HOM is tyrosine phosphorylated in response to macrophage cell adhesion and that it forms a signalling complex with Fyb. We suggest that dephosphorylation of SKAP-HOM and Fyb by YopH allows yersiniae to interfere with a novel adhesion-regulated signal transduction pathway in macrophages.
Depth Video Enhancement Based on Weighted Mode Filtering (2011)

This paper presents a novel approach for depth video enhancement. Given a high-resolution color video and its corresponding low-quality depth video, we improve the quality of the depth video by increasing its resolution and suppressing noise. For that, a weighted mode filtering method is proposed based on a joint histogram. When the histogram is generated, the weight based on color similarity between reference and neighboring pixels on the color image is computed and then used for counting each bin on the joint histogram of the depth map. A final solution is determined by seeking a global mode on the histogram. We show that the proposed method provides the optimal solution with respect to L(1) norm minimization. For temporally consistent estimate on depth video, we extend this method into temporally neighboring frames. Simple optical flow estimation and patch similarity measure are used for obtaining the high-quality depth video in an efficient manner. Experimental results show that the proposed method has outstanding performance and is very efficient, compared with existing methods. We also show that the temporally consistent enhancement of depth video addresses a flickering problem and improves the accuracy of depth video.