gebhart/patrepeval huggingface dataset:
Epitaxy of Porous and Photocatalytically Active TiO2 Films at 50°C (2011)

Epitaxial anatase TiO2 thin films were grown on (001) oriented SrTiO3 single crystal substrates by liquid phase deposition at 50°C. The film consisted of nanosized crystallites and exhibited a significant void fraction of 31 %. This contributed to the cracking of thicker films due to the generation of capillary stresses in the nanosized pores during drying. This porosity also comes in useful during the photodegradation of a methylene blue dye by an as-grown film.
Polysaccharides of Algae. XXXIV: Detection of iota-Carrageenan in <i>Phyllophora brodiaei </i>(Turn.) J. Ag. (Rhodophyta) Using 13C-NMR Spectroscopy (1985)

Article Polysaccharides of Algae. XXXIV: Detection of iota-Carrageenan in Phyllophora brodiaei (Turn.) J. Ag. (Rhodophyta) Using 13C-NMR Spectroscopy was published on January 1, 1985 in the journal Botanica Marina (volume 28, issue 9).
Optimization of Femtosecond Laser Polymerized Structural Niches to Control Mesenchymal Stromal Cell Fate in Culture (2014)

We applied two-photon polymerization to fabricate 3D synthetic niches arranged in complex patterns to study the effect of mechano-topological parameters on morphology, renewal and differentiation of rat mesenchymal stromal cells. Niches were formed in a photoresist with low auto-fluorescence, which enabled the clear visualization of the fluorescence emission of the markers used for biological diagnostics within the internal niche structure. The niches were structurally stable in culture up to three weeks. At three weeks of expansion in the niches, cell density increased by almost 10-fold and was 67% greater than in monolayer culture. Evidence of lineage commitment was observed in monolayer culture surrounding the structural niches, and within cell aggregates, but not inside the niches. Thus, structural niches were able not only to direct stem cell homing and colony formation, but also to guide aggregate formation, providing increased surface-to-volume ratios and space for stem cells to adhere and renew, respectively.
Cardiac T<sub>1</sub> mapping: Techniques and applications (2019)

A key advantage of cardiac magnetic resonance (CMR) imaging over other cardiac imaging modalities is the ability to perform detailed tissue characterization. CMR techniques continue to evolve, with advanced imaging sequences being developed to provide a reproducible, quantitative method of tissue interrogation. The T 1 mapping technique, a pixel‐by‐pixel method of quantifying T 1 relaxation time of soft tissues, has been shown to be promising for characterization of diseased myocardium in a wide variety of cardiomyopathies. In this review, we describe the basic principles and common techniques for T 1 mapping and its use for native T 1 , postcontrast T 1 , and extracellular volume mapping. We will review a wide range of clinical applications of the technique that can be used for identification and quantification of myocardial edema, fibrosis, and infiltrative diseases with illustrative clinical examples. In addition, we will explore the current limitations of the technique and describe some areas of ongoing development. Level of Evidence: 5 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:1336–1356.
The yeast his3 promoter contains at least two distinct elements. (1982)

Phenotypic analysis of 65 mutations indicates that the yeast his3 promoter is composed of at least two separate regions of DNA. Each is necessary, but neither is sufficient for wild-type levels of his3 expression. Deletion mutations that destroy either promoter element express his3 poorly or not at all. The upstream element is located between 112 and 155 base pairs before the site of transcriptional initiation (nucleotides -112 to -155). A comparison of derivatives strongly suggests that the downstream element maps somewhere between nucleotides -32 and -52 and includes a sequence between nucleotides -45 and -52. This location coincides with sequences conserved before most eukaryotic genes(the TATA box region). By using derivatives in which his3 sequences are replaced by a small fragment of coliphage M13 DNA, three properties of the his3 promoter were established. First, his3 TATA box deletions fail to express his3 because they lack specific sequences and not because they disrupt spacing relationships between other sequences. Second, the TATA box region can be replaced functionally by the one orientation of the M13 DNA fragment that contains a TATA-like sequence. Third, the distance between the two elements (normally 90 base pairs) can be varied between 40 and 160 base pairs without markedly affecting promoter function. These results strongly suggest that yeast RNA polymerase II, unlike its Escherichia coli counterpart, does not bind simultaneously to both promoter elements, and they add further support to the view that the upstream element is not part of a transcriptionally competent binding site. This ability of the his3 upstream promotor element to act at a long and variable distance is similar to properties of viral enhancer sequences and is reminiscent of position effects in yeast.
Dye‐sensitized photoinitiated cationic polymerization. The system: Perylene–triarylsulfonium salts (1979)

Abstract Perylene has been found to photosensitize the photolysis of triarylsulfonium salts at wavelengths from 390 to 475 nm. Using perylene in combination with various triarylsulfonium salt photoinitiators, the photoinduced cationic polymerizations of cyclohexene oxide and 2‐chloroethyl vinyl ether have been demonstrated using light of these wavelengths.
The Preparation of TiO2 Film by the Sol-Gel Method and Evaluation of Its Self-Cleaning Property (2018)

TiO₂ sol was produced by the sol-gel method through the hydrolysis and the aging of tetrabutyl titanate and the TiO₂ film was obtained by dipping and uniform lifting of the acid-treated and ultrasound-treated clean glass slides into the TiO₂ sol followed by aging, drying, and calcination. The effect of the hydrolysis control agents to the formed sol was researched and the crystalline state, the morphology, and the photocatalytic properties of the products after calcination were characterized. The structural morphology, the contact angles before and after illumination, and the self-cleaning properties of the TiO₂ film were characterized as well. The results showed that by using acetylacetone as the hydrolysis control agent, the formed TiO₂ sol had relatively high stability. The product after the calcination of the TiO₂ sol was of single anatase type with crystalline size of 18-20 nm and it could degrade nearly 100% of methylene blue after 90 min illumination. The formed TiO₂ film is compact, continuous, smooth, and had the properties of super-hydrophilicity (after 30 min illumination due to its contact angle decreasing from 21° to nearly 0°) and anti-fogging capability, which indicated its excellent self-cleaning property.
Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition. (2010)

Oral administration of piperine is able to partially prevent the increase of blood pressure caused by chronic L-NAME administration. This effect is probably caused by the blockage of voltage-dependent calcium channels and supported by filamentous actin disassembly (Tab. 1, Fig. 2, Ref. 35).
Sleeping beauty: a novel cancer gene discovery tool (2006)

The National Cancer Institute and the National Human Genome Research Institute recently announced a 3-year 100-million-dollar pilot study to use large-scale resequencing of genes in human tumors to identify new cancer genes. The hope is that some of these genes can be used as drug targets for developing better therapeutics for treating cancer. Although this effort will identify new cancer genes, it could be made more efficient by preferentially resequencing genes identified as novel candidate cancer genes in animal models of cancer. Although retroviral insertional mutagenesis has proven to be an effective tool for identifying novel cancer genes in the mouse, these studies are limited by the fact that retroviral mutagenesis primarily induces hematopoietic and mammary cancer, but little else, while the majority of cancers affecting humans are solid tumors. Recently, two groups have shown that sleeping beauty (SB) transposon-based insertional mutagenesis can also identify novel candidate cancer genes in the mouse. Unlike retroviral infection, SB transposition can be controlled to mutagenize any target tissue and thus potentially induce many different kinds of cancer, including solid tumors. SB transposition in animal models of cancer could therefore greatly facilitate the identification of novel human cancer genes and the development of better cancer therapies.
Alpha 1-protease inhibitor moderates human neutrophil elastase-induced emphysema and secretory cell metaplasia in hamsters (1990)

A study was undertaken to determine whether emphysema and airway secretory cell metaplasia, induced in hamsters by intratracheal treatment with human neutrophil elastase (HNE), could be moderated by pretreatment with human alpha 1-protease inhibitor (API). API (4.9 mg) was given intratracheally to hamsters 1 h before 0.3 mg HNE. Eight weeks later, lung volumes and pressure-volume relationships were measured in the anaesthetized animals. Mean linear intercepts and secretory cell indices were measured in lung sections. API given 1 h before HNE moderated the development of bronchial secretory cell metaplasia. The severity of emphysema was reduced by 75%. Clearance studies indicated that 80% of the functional activity of instilled API could be lavaged from the lungs after 1 h, indicating a 4 h half-life in the lavageable compartment of the lungs. We calculate that for 50% protection from emphysema the molar ratio of lavageable API to HNE at the time of HNE instillation was 4.8 as compared with 0.78 for 50% inhibition of elastolytic activity in vitro, indicating that API is only 16% as efficient in vivo as compared with its in vitro HNE inhibitory effectiveness. Nevertheless, we conclude that human API given intratracheally is efficacious against HNE-induced emphysema and secretory cell metaplasia.
Learning to Extract Conditional Knowledge for Question Answering using Dialogue (2016)

Knowledge based question answering (KBQA) has attracted much attention from both academia and industry in the field of Artificial Intelligence. However, many existing knowledge bases (KBs) are built by static triples. It is hard to answer user questions with different conditions, which will lead to significant answer variances in questions with similar intent. In this work, we propose to extract conditional knowledge base (CKB) from user question-answer pairs for answering user questions with different conditions through dialogue. Given a subject, we first learn user question patterns and conditions. Then we propose an embedding based co-clustering algorithm to simultaneously group the patterns and conditions by leveraging the answers as supervisor information. After that, we extract the answers to questions conditioned on both question pattern clusters and condition clusters as a CKB. As a result, when users ask a question without clearly specifying the conditions, we use dialogues in natural language to chat with users for question specification and answer retrieval. Experiments on real question answering (QA) data show that the dialogue model using automatically extracted CKB can more accurately answer user questions and significantly improve user satisfaction for questions with missing conditions.
XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway (2013)

These findings suggested that TNKS1 may be a potential molecule target for the treatment of NB.
HyGCN: A GCN Accelerator with Hybrid Architecture (2020)

In this work, we first characterize the hybrid execution patterns of GCNs on Intel Xeon CPU. Guided by the characterization, we design a GCN accelerator, HyGCN, using a hybrid architecture to efficiently perform GCNs. Specifically, first, we build a new programming model to exploit the fine-grained parallelism for our hardware design. Second, we propose a hardware design with two efficient processing engines to alleviate the irregularity of Aggregation phase and leverage the regularity of Combination phase. Besides, these engines can exploit various parallelism and reuse highly reusable data efficiently. Third, we optimize the overall system via inter-engine pipeline for inter-phase fusion and priority-based off-chip memory access coordination to improve off-chip bandwidth utilization. Compared to the state-of-the-art software framework running on Intel Xeon CPU and NVIDIA V100 GPU, our work achieves on average 1509$\times$ speedup with 2500$\times$ energy reduction and average 6.5$\times$ speedup with 10$\times$ energy reduction, respectively.
<i>In vivo</i> Imaging and Quantitation of Adoptively Transferred Human Antigen-Specific T Cells Transduced to Express a Human Norepinephrine Transporter Gene (2007)

Sequential imaging of genetically marked effector cells after adoptive transfer in vivo has greatly enhanced analyses of their biodistribution, growth, and activity both in animal models and in clinical trials of cellular immunotherapy. However, the immunogenicity of cells expressing xenogeneic reporter constructs limits their survival and clinical utility. To address this limitation, we have evaluated a human norepinephrine transporter (hNET) permitting imaging of transduced cells in vivo with a previously approved clinical grade radiolabeled probe, metaiodobenzylguanidine (MIBG). The hNET gene cDNA was cloned from the SK-N-SH cell line and inserted into a bicistronic retroviral vector also encoding green fluorescent protein. Following transfection, human EBV-specific T lymphocytes seemed fully functional in vitro and also selectively accumulated [(123)I]MIBG. In nonobese diabetic/severe combined immunodeficient mice bearing human EBV lymphoma xenografts, as few as 10(4) transduced T cells injected into the tumors could be imaged by single-photon emission computed tomography (SPECT) or positron emission tomography (PET) after i.v. infusion of [(123)I]MIBG or [(124)I]MIBG, respectively. When hNET(+) EBV-specific T cells were infused i.v., their migration and specific accumulation in EBV(+) tumors expressing their restricting HLA allele could be imaged by SPECT or PET over 28 days. Image intensity was closely correlated with the number of T cells accumulated in targeted tumors. The use of two reporter probes (MIBG and 2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl-5-iodouracil) permitted independent contemporaneous tracking of two distinct EBV-specific T-cell subpopulations expressing different reporter genes (hNET-CD4(+) T cells and HSV-TK-CD8(+) T cells) in the same animal using three-dimensional nuclear modalities (SPECT and PET). The hNET-based system described may thus have significant potential as a nonimmunogenic reporter for extended repeated quantitative in vivo imaging of transduced cells in man.
Integrated Molar Chiral Sensing Based on High-<i>Q</i> Metasurface (2020)

Circular dichroism (CD) spectroscopy is conventionally utilized for the enantiomer-specific analysis of chiral samples, which is of great significance in academia and industry. Recently, metasurfaces have been introduced for enhancing the sensitivity of CD spectroscopy. However, the obtained CD spectrum alone cannot provide the enantiomer composition of a chiral sample. It should be normalized by the molar concentration of chiral molecules, which is usually measured on a different platform. Here, for the first time we demonstrate the integrated acquisition of CD spectrum and molar concentration over an individual metasurface with high sensitivities. High-<i>Q</i> resonances are supported on the metasurface, governed by bound states in the continuum. The generated superchiral field enables a 59-times enhancement of CD signal. Meanwhile, the refractive index-based detection of molar concentration achieves a large figure-of-merit of 80.6. Accordingly, a standard procedure is established for the integrated molar chiral sensing with high sensitivity.
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases (2016)

The retinal pigment epithelium (RPE) is juxtaposed to the overlying sensory retina, and supports the function of the visual system. Among the tasks performed by the RPE are phagocytosis and processing of outer photoreceptor segments through lysosome-derived organelles. These degradation products, stored and referred to as lipofuscin granules, are composed partially of bisretinoids, which have broad fluorescence absorption and emission spectra that can be detected clinically as fundus autofluorescence with confocal scanning laser ophthalmoscopy (cSLO). Lipofuscin accumulation is associated with increasing age, but is also found in various patterns in both acquired and inherited degenerative diseases of the retina. Thus, studying its pattern of accumulation and correlating such patterns with changes in the overlying sensory retina are essential to understanding the pathophysiology and progression of retinal disease. Here, we describe a technique employed by our lab and others that uses cSLO in order to quantify the level of RPE lipofuscin in both healthy and diseased eyes.
Mobility in long-term service architectures and distributed platforms (1998)

This article focuses on the convergence of two technical streams of current interest: (1) service architectures as an innovative, integrated solution to the problems addressed by intelligent networks and telecommunications management networks; and (2) mobile communications systems and related software for their control and management. Its main objectives are to: (a) introduce the state of the art in long-term service architecture (SA); (b) identify the potential benefits of using SA concepts in the design and deployment of mobile communications systems; (c) indicate principles for inclusion of personal and terminal mobility aspects in the SA; and (d) consider the implications of mobility on the distributed processing environment underlying a set of services built according to the SA. The technical content of the article partly reflects work being carried out in international cooperative fora, particularly within the global initiative TINA and selected projects of the European research program ACTS. However, most views expressed here are the result of original evaluation and synthesis carried out by the authors. The timing validity of the article is in the medium to long term, since it targets the development and deployment process of systems that may not be in operation until the turn of the century.
Methods for the Chemical Synthesis of Fullerenes (2004)

C(60) has been synthesized by chemical methods in 12 steps. Lessons learned in the author's laboratory during a decade devoted to the synthesis and study of open geodesic polyarenes strongly influenced the strategy and methodology ultimately employed for preparing a suitable 60-carbon precursor and for closing it up to the fullerene ball. This review provides a personal account of how the new synthetic tools were developed and put to use.
Molecular Cloning of a Gene Encoding Porcine Interferon-β (1992)

A gene encoding the porcine interferon-beta (poIFN-beta) was cloned from a genomic library. The sequence of a potential intronless coding region as well as 1,265 bp of the 5'- and 277 bp of the 3'-flanking regions is presented. The gene is predicted to encode a mature protein of 165 amino acids and a signal peptide of 21 amino acids. This probable poIFN-beta shows high homology (63%) with human (hu) IFN-beta at the amino acid level, but less with porcine (po) IFN-alpha 1 (32%). It contains three cysteines and three potential N-glycosylation sites. A region of the 5' flank (-116 to -159) of the gene is homologous to the IFN gene regulatory element (IRE) of the huIFN-beta gene which mediates virus inducibility. Southern blot analysis indicates that the poIFN-beta gene is present as a single copy in the porcine genome. Its expression in porcine peripheral blood leukocytes stimulated in vitro by pseudorabies virus (PRV) was demonstrated at the RNA level both by Northern blot analysis and by in situ hybridization. The latter approach in addition detected only about one IFN-beta mRNA-containing cell per 2,000 PRV-stimulated porcine leukocytes, a frequency in the same range as that for leukocytes containing IFN-alpha mRNA.
Conformational contraction and hydrolysis of hyaluronate in sodium hydroxide solutions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational contraction and hydrolysis of hyaluronate in sodium hydroxide solutionsSnehasish Ghosh, Ivan Kobal, Dino Zanette, and Wayne F. ReedCite this: Macromolecules 1993, 26, 17, 4685–4693Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ma00069a042https://doi.org/10.1021/ma00069a042research-articleACS PublicationsRequest reuse permissionsArticle Views306Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Superlattice conduction in superlattice modulation-doped field-effect transistors (1987)

We fabricated superlattice modulation-doped field-effect transistors where the doping is concentrated in GaAs narrow quantum wells separated by undoped AlGaAs barriers. As the doped AlGaAs regions are eliminated from such a structure, the concentration of traps generally associated with doping of AlGaAs is low. We observed the threshold voltage shift of only 140 mV with temperature change from 77 to 300 K (which should be compared to the shift of 200–300 mV in conventional modulation-doped field-effect transistors). Peak transconductances of 310 mS/mm at 300 K and 321 mS/mm at 77 K have been obtained. An interesting feature of this device is the complicated dependence of the transconductance on the gate voltage which has two peaks at 77 K and one sharp peak at 300 K. These peaks are caused by the parallel conduction paths in the superlattice at high gate voltages and by the gate leakage current. This parallel conduction in GaAs-doped quantum wells may be used in order to achieve larger voltage swings in superlattice modulation-doped field-effect transistors.
Secondary autoimmune diseases following alemtuzumab therapy for multiple sclerosis (2012)

Alemtuzumab is a humanized monoclonal antibody that causes prolonged lymphopenia. In a recent Phase III trial, alemtuzumab was shown to reduce both the annualized relapse rate and the rate of sustained accumulation of disability by over 70% when compared with IFN-β1a. However, the drug is associated with thyroid autoimmunity in approximately a third of treated patients, as well as other secondary autoimmune conditions in smaller numbers. Secondary autoimmunity typically arises during reconstitution of the lymphocyte repertoire. Individuals with high baseline circulating levels of IL-21 are at highest risk of developing autoimmunity following treatment with alemtuzumab.