gebhart/patrepeval huggingface dataset:
Dynamics in synthetic oligonucleotides. A solid-state deuterium NMR study (1990)

Solid-state 2H NMR spectroscopy was used to investigate dynamics in the [methyl-2H]thymidine-labeled oligonucleotide [d(CGCGAAT*T*CGCG)]2. Quadrupole echo line shapes, spin-lattice relaxation, and quadrupolar echo decay rates were investigated as a function of hydration W (moles of water/moles of nucleotide) between 0 and approximately 30. The amplitude of the base motion, modeled as a fast four-site libration, or diffusion in a cone, increased slightly with higher levels of hydration. A slower component of motion about the helix axis appears at W approximately 10 and increases in rate and amplitude, leading to the intermediate rate line shape observed at W approximately 21.
Driving Perpendicular Heat Flow: (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>p</mml:mi><mml:mo mathvariant="bold">×</mml:mo><mml:mi>n</mml:mi></mml:math>)-Type Transverse Thermoelectrics for Microscale and Cryogenic Peltier Cooling (2013)

Whereas thermoelectric performance is normally limited by the figure of merit ZT, transverse thermoelectrics can achieve arbitrarily large temperature differences in a single leg even with inferior ZT by being geometrically tapered. We introduce a band-engineered transverse thermoelectric with p-type Seebeck in one direction and n-type orthogonal, resulting in off-diagonal terms that drive heat flow transverse to electrical current. Such materials are advantageous for microscale devices and cryogenic temperatures--exactly the regimes where standard longitudinal thermoelectrics fail. InAs/GaSb type II superlattices are shown to have the appropriate band structure for use as a transverse thermoelectric.
Acetylation phenotype in colorectal carcinoma. (1987)

Sulfamethazine acetylation phenotype was determined in 49 patients with cancer of the colon or rectum, 41 old, and 45 young control subjects. Metabolic clearance of sulfamethazine, plasma ratio of N-acetylsulfamethazine:N-acetylsulfamethazine plus sulfamethazine and urinary ratio of N-acetylsulfamethazine:N-acetylsulfamethazine plus sulfamethazine were used to classify subjects into slow and fast acetylation phenotypes. All three measures gave similar results. The proportions of slow and fast acetylators were similar in both control groups and there were significantly more fast acetylators in the cancer group than in the control groups (chi 2 = 5.0-8.5; P less than 0.05). The data suggest that there may be an association between acetylation phenotype and colorectal carcinoma.
DIETOS: A recommender system for adaptive diet monitoring and personalized food suggestion (2016)

Nowadays there is a widespread diffusion of mobile applications for weight and diet management. Even though, the most popular apps are not usually experimented in clinical contexts, as well as apps are not supported by medical evidence. Further research is necessary to assess the effectiveness of apps for weight and diet management. Moreover, there are few examples of food recommender systems that provide to the users nutritional facts about suitable food choices and take into account individual physiological status and environmental situations. We propose DIETOS (DIET Organizer System), a recommender system for the adaptive delivery of nutrition contents to improve the quality of life of both healthy people and individuals affected by chronic diet-related diseases. The proposed system is able to build a user's health profile, and provides individualized nutritional recommendation according to the health profile. The profile is created through the use of dynamic real-time questionnaires prepared by medical doctors and compiled by the users. The health profile includes information about health status and eventual chronic diseases. The first prototype of the system (available online at http://www.easyanalysis.it/dietos), includes a catalogue of typical Calabrian foods compiled by nutrition specialists (Calabria is a region of the southern Italy). DIETOS can suggest not only the use of specific foods compatible with the health status, but also it may give dietary indications related to some specific pathologies or health conditions.
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:mi mathvariant="script">F</mml:mi><mml:mtext>-</mml:mtext><mml:mi mathvariant="italic">SU</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mn>5</mml:mn><mml:mo stretchy="false">)</mml:mo></mml:math> (2009)

We construct three flipped SU(5)×U(1)X models from F-theory, and consider two such models from free fermionic string model building. To achieve the decoupling scenario in F-theory models and the string-scale gauge coupling unification in free fermionic models, we introduce vector-like particles at the TeV scale that can be observed at the Large Hadron Collider. We study gauge coupling unification, and find that proton decay is within the reach of the future Hyper-Kamiokande experiment. In these models, the doublet–triplet splitting problem and monopole problem can be solved, the neutrino masses and mixings can be explained via the double seesaw or seesaw mechanism, the observed baryon asymmetry can be obtained through leptogenesis, the hybrid inflation can be realized, and the correct cosmic primordial density fluctuations can be generated.
UVA‐Photosensitivityof cis‐Diamminedichloro‐Platinum(II)‐Modified DNA (1995)

cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the interstrand cross-link is demonstrated.
PILOT-AND FULL-SCALE DEMONSTRATION OF ADVANCED MERCURY CONTROL TECHNOLOGIES FOR LIGNITE-FIRED POWER PLANTS (2005)

The overall objective of the project was to develop advanced innovative mercury control technologies to reduce mercury emissions by 50%-90% in flue gases typically found in North Dakota lignite-fired power plants at costs from one-half to three-quarters of current estimated costs. Power plants firing North Dakota lignite produce flue gases that contain >85% elemental mercury, which is difficult to collect. The specific objectives were focused on determining the feasibility of the following technologies: Hg oxidation for increased Hg capture in dry scrubbers, incorporation of additives and technologies that enhance Hg sorbent effectiveness in electrostatic precipitators (ESPs) and baghouses, the use of amended silicates in lignite-derived flue gases for Hg capture, and the use of Hg adsorbents within a baghouse. The approach to developing Hg control technologies for North Dakota lignites involved examining the feasibility of the following technologies: Hg capture upstream of an ESP using sorbent enhancement, Hg oxidation and control using dry scrubbers, enhanced oxidation at a full-scale power plant using tire-derived fuel and oxidizing catalysts, and testing of Hg control technologies in the Advanced Hybrid{trademark} filter.
Stimulus-specific Modulation of the Cation Channel TRPV4 by PACSIN 3 (2008)

TRPV4, a member of the vanilloid subfamily of the transient receptor potential (TRP) channels, is activated by a variety of stimuli, including cell swelling, moderate heat, and chemical compounds such as synthetic 4alpha-phorbol esters. TRPV4 displays a widespread expression in various cells and tissues and has been implicated in diverse physiological processes, including osmotic homeostasis, thermo- and mechanosensation, vasorelaxation, tuning of neuronal excitability, and bladder voiding. The mechanisms that regulate TRPV4 in these different physiological settings are currently poorly understood. We have recently shown that the relative amount of TRPV4 in the plasma membrane is enhanced by interaction with the SH3 domain of PACSIN 3, a member of the PACSIN family of proteins involved in synaptic vesicular membrane trafficking and endocytosis. Here we demonstrate that PACSIN 3 strongly inhibits the basal activity of TRPV4 and its activation by cell swelling and heat, while leaving channel gating induced by the synthetic ligand 4alpha-phorbol 12,13-didecanoate unaffected. A single proline mutation in the SH3 domain of PACSIN 3 abolishes its inhibitory effect on TRPV4, indicating that PACSIN 3 must bind to the channel to modulate its function. In line herewith, mutations at specific proline residues in the N terminus of TRPV4 abolish binding of PACSIN 3 and render the channel insensitive to PACSIN 3-induced inhibition. Taken together, these data suggest that PACSIN 3 acts as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-specific manner.
Genetic selection of sox1GFP‐expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation (2006)

Because of their ability to proliferate and to differentiate into diverse cell types, embryonic stem (ES) cells are a potential source of cells for transplantation therapy of various diseases, including Parkinson's disease. A critical issue for this potential therapy is the elimination of undifferentiated cells that, even in low numbers, could result in teratoma formation in the host brain. We hypothesize that an efficient solution would consist of purifying the desired cell types, such as neural precursors, prior to transplantation. To test this hypothesis, we differentiated sox1-green fluorescent protein (GFP) knock-in ES cells in vitro, purified neural precursor cells by fluorescence-activated cell sorting (FACS), and characterized the purified cells in vitro as well as in vivo. Immunocytofluorescence and RT-PCR analyses showed that this genetic purification procedure efficiently removed undifferentiated pluripotent stem cells. Furthermore, when differentiated into mature neurons in vitro, the purified GFP+ cell population generated enriched neuronal populations, whereas the GFP- population generated much fewer neurons. When treated with dopaminergic inducing signals such as sonic hedgehog (SHH) and fibroblast growth factor-8 (FGF8), FACS-purified neural precursor cells responded to these molecules and generated dopaminergic neurons as well as other neural subtypes. When transplanted, the GFP+ cell population generated well contained grafts containing dopaminergic neurons, whereas the GFP- population generated significantly larger grafts (about 20-fold) and frequent tumor-related deaths in the transplanted animals. Taken together, our results demonstrate that genetic purification of neural precursor cells using FACS isolation can effectively remove unwanted proliferating cell types and avoid tumor formation after transplantation.
Performance Management of Virtual Machines via Passive Measurement and Machine Learning (2012)

Virtualization is commonly used to efficiently operate servers in data centers. The autonomic management of virtual machines enhances the advantages of virtualization. For the development of such management, it is important to establish a method to accurately detect performance degradation in virtual machines. This paper proposes a method that detects degradation via the passive measurement of traffic exchanged by virtual machines. Using passive traffic measurement is advantageous because it is robust against heavy loads, nonintrusive to the managed machines, and independent of hardware/software platforms. From the measured traffic metrics, performance state is determined by a machine learning technique that algorithmically determines the complex relationship between traffic metrics and performance degradation from training data. Moreover, the feasibility and effectiveness of the proposed method are confirmed experimentally.
The language of deceit: An investigation of the verbal clues to deception in the interrogation context. (1996)

We examined the hypothesis that reliable verbal indicators of deception exist in the interrogation context. Participants were recruited for a study addressing “security effectiveness” and either committed a theft “to test the effectiveness of a new security guard” or carried out a similar but innocuous task. They then provided either (1) a truthful alibi, (2) a partially deceptive account, (3) a completely false alibi, or (4) a truthful confession regarding the theft to “an interrogator hired for the purpose of investigating thefts” with a monetary incentive for convincing the interrogator of their truthfulness. Results indicated that only 3 out of the 18 (16.7%) clues tested significantly differentiated the truthful and deceptive accounts. All 3 clues were derived from the Statement Validity Analysis (SVA) technique (amount of detail reported, coherence, and admissions of lack of memory). Implications for credibility assessment in forensic interrogations are discussed.
Export of Virulence Genes and Shiga Toxin by Membrane Vesicles of <i>Escherichia coli</i> O157:H7 (1999)

Membrane vesicles released by Escherichia coli O157:H7 into culture medium were purified and analyzed for protein and DNA content. Electron micrographs revealed vesicles that are spherical, range in size from 20 to 100 nm, and have a complete bilayer. Analysis of vesicle protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis demonstrates vesicles that contain many proteins with molecular sizes similar to outer membrane proteins and a number of cellular proteins. Immunoblot (Western) analysis of vesicles suggests the presence of cell antigens. Treatment of vesicles with exogenous DNase hydrolyzed surface-associated DNA; PCR demonstrated that vesicles contain DNA encoding the virulence genes eae, stx1 and stx2, and uidA, which encodes for beta-galactosidase. Immunoblot analysis of intact and lysed, proteinase K-treated vesicles demonstrate that Shiga toxins 1 and 2 are contained within vesicles. These results suggest that vesicles contain toxic material and transfer experiments demonstrate that vesicles can deliver genetic material to other gram-negative organisms.
Machs Prinzip (2012)

Aufgrund der Gravitation ziehen sich alle Objekte im Universum gegenseitig an. Ernst Mach dachte darüber nach, warum Objekte, die weit weg sind, Einfluss darauf haben, wie sich Dinge in der Nähe bewegen und drehen. Er erkannte, dass „Masse dort, Trägheit hier beeinflusst“. Doch dazu musste erst geklärt werden, wie man überhaupt sagen kann, dass sich etwas bewegt.
Network Service Header TLVs (2017)

This draft describes Network Service Header (NSH) MD-Type 2 metadata
TLVs that can be used within a service function path.
Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets (2013)

The aim of this research was to develop a new hydrophilic matrix system containing norfloxacin (NFX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxypropylmethylcellulose or poly(ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at 40 ± 2°C and 75 ± 5% relative humidity), and the film-coating process is recommended to avoid NFX photodegradation. The dissolution profiles demonstrated an extended-release of NFX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo.
Syntheses and Oxide-Ion Conductivity of Highly c-Axis-Oriented Polycrystals of Apatite-Type Lanthanum Silicates (2014)

We have successfully prepared the three types of highly c-axis-oriented polycrystalline materials of lanthanum silicate apatite（La9.33Si6O26, La9.50Si6O26.25 and La9.50Si5.87O26）by isothermal heating of the diffusion couples consisting of La2SiO5 and La2Si2O7 at 1873 K for 50-100 h. The resulting polycrystals were subsequently characterized using polarizing microscopy, X-ray diffration and impedance spectroscopy. The annealed couples were mechanically processed, and the thin-plate electrolytes consisting of the grain-aligned polycrystals were obtained. The oxide-ion conductivity along the c-axis of oxygen hyper-stoichiometric apatite, La9.50Si6O26.25,was ca. 2.5 times higher than that of oxygen stoichiometric apatite, La9.33Si6O26, at 723-973 K. The polycrystalline material of Si-deficient apatite, La9.50Si5.87O26, showed, among the three types of apatite polycrystals, the highest conductivity above 850 K; the conductivity at 873 K was 4.2×10−2 S/cm.
Comparison of Plasmid DNA Preparation Methods for Direct Gene Transfer and Genetic Immunization (1996)

Plasmid DNA is widely used for direct gene transfer in animals to study gene therapy, gene regulation, drug delivery and genetic immunization. Here we compare cesium chloride and anion-exchange purified plasmid DNA for direct gene transfer in mouse muscle and show no differences in efficiency of transfection with reporter genes or in humoral response to DNA-based immunization.
Rate and Power Allocation for Layered Transmission With Superposition Coding (2007)

We consider layered transmission of a Gaussian source over a quasi-static fading channel. A broadcast strategy is used in which multiple layers of source data are superimposed, and each layer is allocated a different power and transmission rate. For a multiple-antenna system where either the transmitter or the receiver has a single antenna, we propose a low-complexity algorithm for minimizing the expected end-to-end distortion of the received signal. Numerical results for a Rayleigh fading channel are presented, and the performance gain over a time-sharing strategy is quantified. It is numerically shown that for a wide range of operating conditions, equal rate allocation is as good as unequal rate allocation.
Behavioural response of female Culex pipiens pallens to common host plant volatiles and synthetic blends (2015)

Our results demonstrate that female Cx. pipiens pallens is differentially attracted by a variety of compounds at different concentrations. Alteration of the concentration strongly affects the attractiveness of the synthetic blend. Several floral scent volatiles might be the universal olfactory cues for various mosquito species to locate their nectar host plants, which could be potentially used in trapping devices for surveillance and control of them.
Advancing Monitoring in Microservices Systems (2019)

Monitoring is a core reliability engineering practice to gain insights into production systems. New trends in microservices exacerbate the role of monitoring. This paper discusses key challenges in microservices monitoring. We introduce our proposal for a novel monitoring framework, which aims to cope with existing challenges by means of non-intrusive techniques that capitalize on passive tracing and log analysis. We present our ongoing work on the topic and preliminary outcomes.
Modeling Texture in Deep 3D CNN for Survival Analysis (2020)

Radiomics has shown remarkable potential for predicting the survival outcome for various types of cancers such as pancreatic ductal adenocarcinoma (PDAC). However, to date, there has been limited research using convolutional neural networks (CNN) with radiomic methods for this task, due to their requirement for large training sets. To overcome this issue, we propose a new type of radiomic descriptor modeling the distribution of learned features with a Gaussian mixture model (GMM). These parametric features (GMM-CNN) are computed from gross tumor volumes of PDAC patients defined semi-automatically in pre-operative computed tomography (CT) scans. We use the proposed GMM-CNN features as input to a robust classifier based on random forests (RF) to predict the survival outcome of patients with PDAC. Our experiments assess the advantage of GMM-CNN compared to employing the same 3D CNN model directly, standard radiomic (i.e., histogram, texture and shape), conditional entropy (CENT) based on 3DCNN, and clinical features (i.e., serum carbohydrate antigen 19-9 and chemotherapy neoadjuvant). Using the RF model (100 samples for training; 59 samples for validation), GMM-CNN features provided the highest area under the ROC curve (AUC) of 72.0% (p = 6.4×10<sup>-5</sup>) compared to 64.0% (p = 0.01) for the 3D CNN model output, 66.8% (p = 0.01) for standard radiomic features, 64.2% (p = 0.003) for CENT, and 57.6% (p = 0.3) for clinical variables. Our results suggest that the proposed GMM-CNN features used with a RF classifier can significantly improve the capacity to prognosticate PDAC patients prior to surgery via routinely-acquired imaging data.
Copper Induction of Laccase Isoenzymes in the Ligninolytic Fungus <i>Pleurotus ostreatus</i> (2000)

Pleurotus ostreatus is a white rot basidiomycete that produces several extracellular laccase isoenzymes, including phenol oxidase A1b (POXA1b), POXA2, and POXC. POXC was the most abundant isoenzyme produced under all of the growth conditions examined in this study. Copper was the most efficient inducer of laccase activity among the putative inducers tested. The amounts of all of the previously described laccase isoenzymes increased substantially in copper-supplemented cultures. Under these conditions expression of POX isoenzymes was regulated at the level of gene transcription. It is worth noting that poxa1b mRNA was the most abundant induced transcript at all of the growth times analyzed, and the amount of this mRNA increased until day 7. The discrepancy between the poxa1b transcript and protein amounts can be explained by the presence of a high level of the protein in P. ostreatus cellular extract, which indicated that the POXA1b isoenzyme could be inefficiently secreted and/or that its physiological activity could occur inside the cell or on the cell wall. Moreover, the POXA1b isoenzyme behaved uniquely, as its activity was maximal on the second day of growth and then decreased. An analysis performed with protease inhibitors revealed that the loss of extracellular POXA1b activity could have been due to the presence of specific proteases secreted into the copper-containing culture medium that affected the extracellular POXA1b isoenzyme.