gebhart/patrepeval huggingface dataset:
Speech Analysis for Automatic Speech Recognition (2009)

The classical front end analysis in speech recognition is a spectral analysis which parametrizes the speech signal into feature vectors; the most popular set of them is the Mel Frequency Cepstral Coefficients (MFCC). They are based on a standard power spectrum estimate which is first subjected to a log-based transform of the frequency axis (mel- frequency scale), and then decorrelated by using a modified discrete cosine transform. Following a focused introduction on speech production, perception and analysis, this paper gives a study of the implementation of a speech generative model; whereby the speech is synthesized and recovered back from its MFCC representations. The work has been developed into two steps: first, the computation of the MFCC vectors from the source speech files by using HTK Software; and second, the implementation of the generative model in itself, which, actually, represents the conversion chain from HTK-generated MFCC vectors to speech reconstruction. In order to know the goodness of the speech coding into feature vectors and to evaluate the generative model, the spectral distance between the original speech signal and the one produced from the MFCC vectors has been computed. For that, spectral models based on Linear Prediction Coding (LPC) analysis have been used. During the implementation of the generative model some results have been obtained in terms of the reconstruction of the spectral representation and the quality of the synthesized speech.
Hereditary Spastic Paraplegia (1996)

Hereditary spastic paraplegia (HSP) is a diverse group of inherited disorders characterized by progressive lower-extremity spasticity and weakness. Insight into the genetic basis of these disorders is expanding rapidly. Uncomplicated autosomal dominant, autosomal recessive, and X-linked HSP are genetically heterogeneous: different genes cause clinically indistinguishable disorders. A locus for autosomal recessive HSP is on chromosome 8q. Loci for autosomal dominant HSP have been identified on chromosomes 2p, 14q, and 15q. One locus (Xq22) has been identified for X-linked, uncomplicated HSP and shown to be due to a proteolipoprotein gene mutation in one family. The existence of HSP families for whom these loci are excluded indicates the existence of additional, as yet unidentified HSP loci. There is marked clinical similarity among HSP families linked to each of these loci, suggesting that gene products from HSP loci may participate in a common biochemical cascade, which, if disturbed, results in axonal degeneration that is maximal at the ends of the longest CNS axons. Identifying the single gene defects that cause HSPs distal axonopathy may provide insight into factors responsible for development and maintenance of axonal integrity. We review clinical, genetic, and pathologic features of HSP and present differential diagnosis and diagnostic criteria of this important group of disorders. We discuss polymorphic microsatellite markers useful for genetic linkage analysis and genetic counseling in HSP.
The Herpes Simplex Virus 1 U <sub>L</sub> 34 Protein Interacts with a Cytoplasmic Dynein Intermediate Chain and Targets Nuclear Membrane (2000)

To express the function encoded in its genome, the herpes simplex virus 1 capsid-tegument structure released by deenvelopment during entry into cells must be transported retrograde to the nuclear pore where viral DNA is released into the nucleus. This path is essential in the case of virus entering axons of dorsal root ganglia. The objective of the study was to identify the viral proteins that may be involved in the transport. We report the following findings. (i) The neuronal isoform of the intermediate chain (IC-1a) of the dynein complex pulled down, from lysates of [(35)S]methionine-labeled infected cells, two viral proteins identified as the products of U(L)34 and U(L)31 open reading frames, respectively. U(L)34 protein is a virion protein associated with cellular membranes and phosphorylated by the viral kinase U(S)3. U(L)31 protein is a largely insoluble, evenly dispersed nuclear phosphoprotein required for optimal processing and packaging of viral DNA into preformed capsids. Reciprocal pulldown experiments verified the interaction of IC-1a and U(L)34 protein. In similar experiments, U(L)34 protein was found to interact with U(L)31 protein and the major capsid protein ICP5. (ii) To determine whether U(L)34 protein is transported to the nuclear membrane, a requirement if it is involved in transport, the U(L)34 protein was inserted into a baculovirus vector under the cytomegalovirus major early promoter. Cells infected with the recombinant baculovirus expressed U(L)34 protein in a dose-dependent manner, and the U(L)34 protein localized primarily in the nuclear membrane. An unexpected finding was that U(L)34-expressing cells showed a dissociation of the inner and outer nuclear membranes reminiscent of the morphologic changes seen in cells productively infected with herpes simplex virus 1. U(L)34, like many other viral proteins, may have multiple functions expressed both early and late in infection.
OpenVDAP: An Open Vehicular Data Analytics Platform for CAVs (2018)

In this paper, we envision the future connected and autonomous vehicles (CAVs) as a sophisticated computer on wheels, with substantial on-board sensors as data sources and a variety of services running on top to support autonomous driving or other functions. In general, these services are computationally expensive, especially for the machine learning based applications (e.g., CNN-based object detection). Nevertheless, the on-board computation unit possess limited compute resources, raising a huge challenge to deploy these computation-intensive services on the vehicle. On the contrary, the cloud-based architecture conceptually with unconstrained resources suffers from unexpected extended latency that attributes to the large-scale Internet data transmission; thus, adversely affecting the services' real-time performance, quality of services and user experiences. To address this dilemma, inspired by the promising edge computing paradigm, we propose to build an Open Vehicular Data Analytics Platform (OpenVDAP) for CAVs, which is a full-stack edge based platform including an on-board computing/communication unit, an isolation-supported and security & privacy-preserved vehicle operation system, an edge-aware application library, as well as an optimal workload of?oading and scheduling strategy, allowing CAVs to dynamically detect each service's status, computation overhead and the optimal of?oading destination so that each service could be finished within an acceptable latency and limited bandwidth consumption. Most importantly, contrast to the proprietary platform, OpenVDAP is an open-source platform that offers free APIs and real-?eld vehicle data to the researchers and developers in the community, allowing them to deploy and evaluate applications on the real environment.
Laser-induced breakdown spectroscopy (LIBS): an overview of recent progress and future potential for biomedical applications (2012)

The recent progress made in developing laser-induced breakdown spectroscopy (LIBS) has transformed LIBS from an elemental analysis technique to one that can be applied for the reagentless analysis of molecularly complex biological materials or clinical specimens. Rapid advances in the LIBS technology have spawned a growing number of recently published articles in peer-reviewed journals which have consistently demonstrated the capability of LIBS to rapidly detect, biochemically characterize and analyse, and/or accurately identify various biological, biomedical or clinical samples. These analyses are inherently real-time, require no sample preparation, and offer high sensitivity and specificity. This overview of the biomedical applications of LIBS is meant to summarize the research that has been performed to date, as well as to suggest to health care providers several possible specific future applications which, if successfully implemented, would be significantly beneficial to humankind.
Asp-89: a critical residue in maintaining the oligomeric structure of sheep liver cytosolic serine hydroxymethyltransferase (1999)

Aspartate residues function as proton acceptors in catalysis and are involved in ionic interactions stabilizing subunit assembly. In an attempt to unravel the role of a conserved aspartate (D89) in sheep-liver tetrameric serine hydroxymethyltransferase (SHMT), it was converted into aspargine by site-directed mutagenesis. The purified D89N mutant enzyme had a lower specific activity compared with the wild-type enzyme. It was a mixture of dimers and tetramers with the proportion of tetramers increasing with an increase in the pyridoxal-5'-phosphate (PLP) concentration used during purification. The D89N mutant tetramer was as active as the wild-type enzyme and had similar kinetic and spectral properties in the presence of 500 microM PLP. The quinonoid spectral intermediate commonly seen in the case of SHMT was also seen in the case of D89N mutant tetramer, although the amount of intermediate formed was lower. Although the purified dimer exhibited visible absorbance at 425 nm, it had a negligible visible CD spectrum at 425 nm and was only 5% active. The apo-D89N mutant tetramer was a dimer unlike the apo-form of the wild-type enzyme which was present predominantly as a tetramer. Furthermore the apo mutant dimer could not be reconstituted to the holo-form by the addition of excess PLP, suggesting that dimer-dimer interactions are weak in this mutant. The recently published crystal structure of human liver cytosolic recombinant SHMT indicates that this residue (D90 in the human enzyme) is located at the N-terminal end of the fourth helix of one subunit and packs against K39 from the second N-terminal helix of the other symmetry related subunit forming the tight dimer. D89 is at the interface of tight dimers where the PLP 5'-phosphate is also bound. Mutation of D89 could lead to weakened ionic interactions in the tight dimer interface, resulting in decreased affinity of the enzyme for the cofactor.
The Promise of Targeted α-Particle Therapy (2005)

The use of monoclonal antibodies to deliver radioisotopes directly to tumor cells has become a promising strategy to enhance the antitumor effects of native antibodies. Since the α- and β-particles emitted during the decay of radioisotopes differ in significant ways, proper selection of isotope and antibody combinations is crucial to making radioimmunotherapy a standard therapeutic modality. Because of the short pathlength (50–80 μm) and high linear energy transfer (∼100 keV/μm) of α-emitting radioisotopes, targeted α-particle therapy offers the potential for more specific tumor cell killing with less damage to surrounding normal tissues than β-emitters. These properties make targeted α-particle therapy ideal for the elimination of minimal residual or micrometastatic disease. Radioimmunotherapy using α-emitters such as 213Bi, 211At, and 225Ac has shown activity in several in vitro and in vivo experimental models. Clinical trials have demonstrated the safety, feasibility, and activity of targeted α-particle therapy in the treatment of small-volume and cytoreduced disease. Further advances will require investigation of more potent isotopes, new sources and methods of isotope production, improved chelation techniques, better methods for pharmacokinetic and dosimetric modeling, and new methods of isotope delivery such as pretargeting. Treatment of patients with less-advanced disease and, ultimately, randomized trials comparing targeted α-particle therapy with standard approaches will be required to determine the clinical utility of this approach.
Activation of Akt and eIF4E Survival Pathways by Rapamycin-Mediated Mammalian Target of Rapamycin Inhibition (2005)

The mammalian target of rapamycin (mTOR) has emerged as an important cancer therapeutic target. Rapamycin and its derivatives that specifically inhibit mTOR are now being actively evaluated in clinical trials. Recently, the inhibition of mTOR has been shown to reverse Akt-dependent prostate intraepithelial neoplasia. However, many cancer cells are resistant to rapamycin and its derivatives. The mechanism of this resistance remains a subject of major therapeutic significance. Here we report that the inhibition of mTOR by rapamycin triggers the activation of two survival signaling pathways that may contribute to drug resistance. Treatment of human lung cancer cells with rapamycin suppressed the phosphorylation of p70S6 kinase and 4E-BP1, indicating an inhibition of mTOR signaling. Paradoxically, rapamycin also concurrently increased the phosphorylation of both Akt and eIF4E. The rapamycin-induced phosphorylation of Akt and eIF4E was suppressed by the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002, suggesting the requirement of PI3K in this process. The activated Akt and eIF4E seem to attenuate rapamycin's growth-inhibitory effects, serving as a negative feedback mechanism. In support of this model, rapamycin combined with LY294002 exhibited enhanced inhibitory effects on the growth and colony formation of cancer cells. Thus, our study provides a mechanistic basis for enhancing mTOR-targeted cancer therapy by combining an mTOR inhibitor with a PI3K or Akt inhibitor.
Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis (2013)

Coccidioidomycosis is the endemic mycosis caused by the fungal pathogens Coccidioides immitis and C. posadasii. This review is a summary of the recent advances that have been made in the understanding of this pathogen, including its mycology, genetics, and niche in the environment. Updates on the epidemiology of the organism emphasize that it is a continuing, significant problem in areas of endemicity. For a variety of reasons, the number of reported coccidioidal infections has increased dramatically over the past decade. While continual improvements in the fields of organ transplantation and management of autoimmune disorders and patients with HIV have led to dilemmas with concurrent infection with coccidioidomycosis, they have also led to advances in the understanding of the human immune response to infection. There have been some advances in therapeutics with the increased use of newer azoles. Lastly, there is an overview of the ongoing search for a preventative vaccine.
Contact-dependent promotion of cell migration by the OL-protocadherin–Nap1 interaction (2008)

OL-protocadherin (OL-pc) is a transmembrane protein belonging to the cadherin superfamily, which has been shown to accumulate at cell-cell contacts via its homophilic interaction, but its molecular roles remain elusive. In this study, we show that OL-pc bound Nck-associated protein 1 (Nap1), a protein that regulates WAVE-mediated actin assembly. In astrocytoma U251 cells not expressing OL-pc, Nap1 was localized only along the lamellipodia. However, exogenous expression of OL-pc in these cells recruited Nap1 as well as WAVE1 to cell-cell contact sites. Although OL-pc expression had no effect on the motility of solitary U251 cells, it accelerated their movement when they were in contact with one another, causing concomitant reorganization of F-actin and N-cadherin at cell junctions. OL-pc mutants lacking the Nap1-binding site exhibited no such effect. N-cadherin knockdown mimicked OL-pc expression in enhancing cell movement. These results suggest that OL-pc remodels the motility and adhesion machinery at cell junctions by recruiting the Nap1-WAVE1 complex to these sites and, in turn, promotes the migration of cells.
Genetic markers in the blood of multiple sclerosis patients. (1991)

Poligenetically determined predisposition to multiple sclerosis (MS) defines the way of immunological reaction to environmental factors and leads to clinically manifest disease. Although the connection between MS and some loci of the HLA system has been established, the hereditary predisposition to MS remains to be elucidated. We determined the phenotypes of monogenic hereditary characteristics linked to the surface of red blood cells that were obtained from 45 MS patients and 458 healthy subjects. The antigens on the erythrocytic surface of the ABO, Rh, MN, Ss, Kell, Kidd, Duffy, P and Lewis system were analyzed. Our results demonstrate that the MS patients differ from the normal subjects with regard to the Rh, ABO and Lewis erythrocytic antigens. The Rh positive factor was present in 95.55% of the MS patients compared to 84.29% of the controls, whereas the Rh negative factor was found in only 4.45% of the MS patients and 15.71% of the healthy subjects. The blood group O was demonstrated in 22.22% of the MS patients compared to 40.42% of the healthy persons. The MS patients had the blood group A in 15.11% of the cases as opposed to 43.99% of the subjects in the control groups. The blood group B was found in 22.22% of the MS patients compared to 11.10% of the controls. The distribution of the Lewis system in the MS patients was also demonstrated to be different from that in the general population. The MS patients were found to have less frequently the Le a+b- phenotype (11.12%) and more frequently Le a- b- (13.33%) compared to the healthy subjects who had the Le a+b- phenotype in 12.00% of the cases and Le a- b- in 5.00%.
A Passive Mixer for 60 GHz Applications in CMOS 65nm Technology (2010)

Abstract — A study of the feasibility of a wide band double balanced resistive mixer in the 60 GHz band is done. The device is implemented in a 65nm CMOS technology process. In this paper an approach to design an optimized version of the mixer in terms of the principal figures of merit: conversion loss, port to port isolation and noise figure is shown. The mixer will be a part of an homodyne downconversion system. The conversion loss is 6.9±0.2dB around 60GHz with a − 5dBm of LO drive. The port-to-port isolation for the LO feed through is better than 41dB. The noise figure is 8.39dB. The power dissipation for the mixer depends on the LO buffer that increases the input LO power. Its power consumption is 15mW.
Tantra: Sex, Secrecy, Politics, and Power in the Study of Religion (2005)

Review Article| March 01 2005 Tantra: Sex, Secrecy, Politics, and Power in the Study of Religion Hugh B. Urban Hugh B. Urban Search for other works by this author on: This Site PubMed Google Scholar Nova Religio (2005) 8 (3): 131–132. https://doi.org/10.1525/nr.2005.8.3.131 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Hugh B. Urban; Tantra: Sex, Secrecy, Politics, and Power in the Study of Religion. Nova Religio 1 March 2005; 8 (3): 131–132. doi: https://doi.org/10.1525/nr.2005.8.3.131 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentNova Religio Search This content is only available via PDF. © 2005 by The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
Oxalate in crop plants (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxalate in crop plantsBo Libert and Vincent R. FranceschiCite this: J. Agric. Food Chem. 1987, 35, 6, 926–938Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/jf00078a019https://doi.org/10.1021/jf00078a019research-articleACS PublicationsRequest reuse permissionsArticle Views2204Altmetric-Citations276LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Magnets in medicine (2002)

As permanent magnet materials have developed, attempts have been made to take advantage of their improved properties in medical applications. Uses of magnets in medical applications range from their simple use for retention, through orthopaedics and fracture healing, to magnetomotive artificial hearts and pioneering brain surgery, where magnets are used to guide catheters. Magnets also find use in applications such as magnetic resonance imaging (MRI) scanners and drug delivery systems. This overview, based on an extensive review of the literature, chronicles the development of magnets in medicine and summarises areas where future research will be beneficial.
A Deep Learning Approach for Multimodal Deception Detection (2018)

Automatic deception detection is an important task that has gained momentum in computational linguistics due to its potential applications. In this paper, we propose a simple yet tough to beat multi-modal neural model for deception detection. By combining features from different modalities such as video, audio, and text along with Micro-Expression features, we show that detecting deception in real life videos can be more accurate. Experimental results on a dataset of real-life deception videos show that our model outperforms existing techniques for deception detection with an accuracy of 96.14% and ROC-AUC of 0.9799.
A hybrid Quantum-Inspired Evolutionary Algorithm for open vehicle routing problem (2009)

This paper proposed a hybrid Quantum-Inspired Evolutionary Algorithm (HQEA) with 2-OPT sub-routes optimization for open vehicle routing problem (OVRP). In the HQEA, Quantum-Inspired Evolutionary Algorithm is used for global exploration and 2-OPT algorithm is used to optimize sub-routes for convergence acceleration. Moreover, an encoding method of converting Q-bit representation to integer representation is designed. And genetic operators of quantum crossover and quantum variation are applied to enhance exploration. The proposed HQEA is tested based on classical benchmark problems of VRP. Simulation results and comparisons with other algorithms show that the proposed HQEA has much better exploration quality and it is an effective method for OVRP.
Effect of ${\rm RuCl}_{3}$ on Morphology and Magnetic Properties of CoNi Nanowires (2013)

Ferromagnetic CoNi nanocrystals with different shape and size were synthesized by reduction in liquid polyol via heterogeneous nucleation. Morphological, structural and compositional characterizations of the nanocrystals were performed together with magnetic property measurements. The CoNi nanocrystals can be controlled to form nanowires or nanorods with length of 20-200 nm and diameter of 5-20 nm by using different catalyst concentration in the synthesis. It is found that the magnetic coercivity of the CoNi nanowires/ nanorods depends on the morphology. The highest coercive force of 2.9 kOe was obtained for nanowires of 50 × 200 nm with Co <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">80</sub> Ni <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sub> composition.