gebhart/patrepeval huggingface dataset:
Crosstalk between Estrogen Receptor alpha 36, a Dominant Extra-Nuclear ER, and HER2 Promotes Tumor Cell Survival in Breast Cancer. (2009)

Abstract The ER-α36 protein is a 36kDa novel splice variant of the full length 66kDa ER-α. ER-α36 lacks both transcriptional activation domains of ER-α66 but retains the DNA-binding domain and partial dimerization and ligand-binding domains. It has been shown that ER-α36 could trigger membrane-initiated signaling in ER-α36 over-expressing 293 cells, suggesting that ER-α36 might have functions linked with activation of intracellular signaling.To further explore the mechanism(s) of ER-α36 activation of intracellular signaling, in particular the possible relationship between ER-α36 and HER2 in breast cancer, we performed a pilot study. First, we examined the correlation between ER-α36 and HER2 by immunohistochemistry (IHC) using a specific anti-ER-α36 antibody designed against a unique epitope located in the C-tail of ER-a36 which is not present in ER-α66. The results showed that the expression of ER-α36 was highly associated with HER2 in a cohort of 249 breast tumors (P&lt;0.05). Then, we examined whether ER-α36 physically interacts with HER2 in breast cancer cell lines using co-immunoprecipitation (Co-IP) and Western blotting (WB) experiments. We found that ER-α36 interacts with HER2 in both MCF7/HER2 and BT474 cell lines. Second, we explored whether ER-α36 influences the activation of HER2 and its downstream signaling by knocking down ER-α36 expression in both MCF7/HER2 and BT474 cell lines. We found that knockdown of ER-α36 by siRNA abrogated the activation of P-HER2, as well as Akt and MAPK, in both MCF7/HER2 and BT474 cells. Finally, we asked the key question whether ER-α36 was associated with cell proliferation/survival. Strikingly, we found that when both MCF7/HER2 and BT474 cells were deprived of ER-α36 by siRNA, they died quickly, whereas control cells grew normally.In conclusion, our preliminary data suggests that there might be a crosstalk between ER-α36 and HER2 signaling, and that this crosstalk might promote tumor cell survival through HER2/Akt and/or HER2/MAPK signaling pathways in breast cancer. Thus, ER-α36 may be a valuable biomarker and a novel therapeutic target in breast cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2121.
Identifying Emotions from Walking using Affective and Deep Features (2019)

We present a new data-driven model and algorithm to identify the perceived emotions of individuals based on their walking styles. Given an RGB video of an individual walking, we extract his/her walking gait in the form of a series of 3D poses. Our goal is to exploit the gait features to classify the emotional state of the human into one of four emotions: happy, sad, angry, or neutral. Our perceived emotion recognition approach uses deep features learned via LSTM on labeled emotion datasets. Furthermore, we combine these features with affective features computed from gaits using posture and movement cues. These features are classified using a Random Forest Classifier. We show that our mapping between the combined feature space and the perceived emotional state provides 80.07% accuracy in identifying the perceived emotions. In addition to classifying discrete categories of emotions, our algorithm also predicts the values of perceived valence and arousal from gaits. We also present an EWalk (Emotion Walk) dataset that consists of videos of walking individuals with gaits and labeled emotions. To the best of our knowledge, this is the first gait-based model to identify perceived emotions from videos of walking individuals.
Suppression of Powdery Mildew (<i>Podosphaera pannosa</i>) in Greenhouse Roses by Brief Exposure to Supplemental UV-B radiation (2012)

Ultraviolet (UV)-B (280 to 315 nm) irradiance from 0.1 to 1.2 W m<sup>-2</sup> and exposure times from 2 min to 2 h significantly suppressed powdery mildew (Podosphaera pannosa) in pot rose (Rosa × hybrida 'Toril') via reduced spore germination, infection efficiency, disease severity, and sporulation of surviving colonies. Brief daily exposure to UV-B suppressed disease severity by more than 90% compared with unexposed controls, and severity was held at low levels as long as daily brief exposures continued. Selective removal of wavelengths below 290 nm from the UV lamp sources by cellulose diacetate filters resulted in significant reduction of treatment efficacy. Exposure of plants to 2 h of UV-B during night for 1 week followed by inoculation with P. pannosa did not affect subsequent pathogen development, indicating that the treatment effect was directly upon the exposed pathogen and not operated through the host. Following 20 to 30 days of exposure, chlorophyll and flavonoid content was slightly higher in plants exposed to the highest UV-B levels. Brief daily exposure to UV-B for 5 min at 1.2 W m<sup>-2</sup> or 1 h at 0.1 W m<sup>-2</sup> substantially reduced mildew severity without significant phytotoxicity, and may represent a useful nonchemical option for suppression of powdery mildew in greenhouse roses and, possibly, other crops.
Timing analysis in a logic synthesis environment (1989)

A goal of a logic synthesis system is the automatic generation of area optimised designs that meet timing requirements. The design process involves repeated timing analyses followed by appropriate modifications.
Ventricular response in atrial fibrillation: random or deterministic? (1999)

The ventricular response in atrial fibrillation is often described as "chaotic," but this has not been demonstrated in the strict mathematical sense. A defining feature of chaotic systems is sensitive dependence on initial conditions: similar sequences evolve similarly in the short term but then diverge exponentially. We developed a nonlinear predictive forecasting algorithm to search for predictability and sensitive dependence on initial conditions in the ventricular response during atrial fibrillation. The algorithm was tested for simulated R-R intervals from a linear oscillator with and without superimposed white noise, a chaotic signal (the logistic map) with and without superimposed white noise, and a pseudorandom signal and was then applied to R-R intervals from 16 chronic atrial fibrillation patients. Short-term predictability was demonstrated for the linear oscillators, without loss of predictive ability farther into the future. The chaotic system demonstrated high short-term predictability that declined rapidly further into the future. The pseudorandom signal was unpredictable. The ventricular response in atrial fibrillation was weakly predictable (statistically significant predictability in 8 of 16 patients), without sensitive dependence on initial conditions. Although the R-R interval sequence is not completely unpredictable, a low-dimensional chaotic attractor does not govern the irregular ventricular response during atrial fibrillation.
Mobile Device Interaction in Ubiquitous Computing (2008)

In a world of constant intertwining of virtuality and reality a consistent way of discovering links between the real and the virtual world is needed. Clearly, the interaction with real world objects offers new possibilities for interfaces to reduce task complexity and to embed virtual tasks into the real world. However, this leads to problems in device use. Readymades in our everyday environment already have a function, expressed in its physical form. To link such objects with additional virtual options leads to the question of how such a linkage can be made comprehensible. The construction of reactive environments and intelligent rooms with huge amounts of sensing equipment is a well witnessed direct result. And within these interface metaphors are developed, that allow for the seamless integration of real and virtual objects. Where these intelligent environments come close to Weisers' vision of transparency, they fall short in behave of ubiquity. In this situation mobile devices can fill in. While our environment is not fully equipped with sensors, mobile devices can extend local installations by taking the computational power and the sensory equipment with the user. Acting as magic lenses, they can provide everyday objects with the interfaces needed for device usage. They can display the functions an object provides; they can help in setting up linkages and even help with reconfiguration. At the same time, the mobile devices, acting as virtual tool glasses, can provide an interface only when needed, reflecting the dynamic role an object can play depending on the context the object is used in. Thus, the mobile device, giving real word objects an interface, can be used as tool to scale virtuality to the extend needed.
MicroRNA-Guided Processing Impairs <i>Plum Pox Virus</i> Replication, but the Virus Readily Evolves To Escape This Silencing Mechanism (2006)

Since the discovery of microRNA (miRNA)-guided processing, a new type of RNA silencing, the possibility that such a mechanism could play a role in virus defense has been proposed. In this work, we have analyzed whether Plum pox virus (PPV) chimeras bearing miRNA target sequences (miR171, miR167, and miR159), which have been reported to be functional in Arabidopsis, were affected by miRNA function in three different host plants. Some of these PPV chimeras had clearly impaired infectivity compared with those carrying nonfunctional miRNA target sequences. The behaviors of PPV chimeras were similar but not identical in all the plants tested, and the deleterious effect on virus infectivity depended on the miRNA sequence cloned and on the site of insertion in the viral genome. The effect of the miRNA target sequence was drastically alleviated in transgenic plants expressing the silencing suppressor P1/HCPro. Furthermore, we show that virus chimeras readily escape RNA silencing interference through mutations within the miRNA target sequence, which mainly affected nucleotides matching the 5'-terminal region of the miRNA.
Inducible rodent models of acquired podocyte diseases (2008)

Glomerular diseases remain the leading cause of chronic and end-stage kidney disease. Significant advances in our understanding of human glomerular diseases have been enabled by the development and better characterization of animal models. Diseases of the glomerular epithelial cells (podocytes) account for the majority of proteinuric diseases. Rodents have been extensively used experimentally to better define mechanisms of disease induction and progression, as well as to identify potential targets and therapies. The development of podocyte-specific genetically modified mice has energized the research field to better understand which animal models are appropriate to study acquired podocyte diseases. In this review we discuss inducible experimental models of acquired nondiabetic podocyte diseases in rodents, namely, passive Heymann nephritis, puromycin aminonucleoside nephrosis, adriamycin nephrosis, liopolysaccharide, crescentic glomerulonephritis, and protein overload nephropathy models. Details are given on the model backgrounds, how to induce each model, the interpretations of the data, and the benefits and shortcomings of each. Genetic rodent models of podocyte injury are excluded.
OmniSeer: A Cognitive Framework for User Modeling, Reuse of Prior and Tacit Knowledge, and Collaborative Knowledge Services (2005)

This paper describes the current state of the OmniSeer system. OmniSeer supports intelligence analysts in the handling of massive amounts of data, the construction of scenarios, and the management of hypotheses. OmniSeer models analysts with dynamic user models that capture an analyst's context, interests, and preferences, thus enabling more efficient and effective information retrieval. OmniSeer explicitly represents the prior and tacit knowledge of analysts, thus enabling transfer and reuse of such knowledge. Both the user and cognitive models employ a Bayesian network fragment representation, which supports principled probabilistic reasoning and analysis. An independent evaluation of OmniSeer was carried out at NIST and will be used to guide further development.
Baseline Characteristics of Patients With HF With Mildly Reduced and Preserved Ejection Fraction (2022)

DELIVER is the largest and broadest clinical trial of this population to date and enrolled high-risk, well-treated patients with HF with mildly reduced and preserved LVEF. (Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure [NCT03619213]).
The semantics of query modification (2010)

We present a method that exploits 'linked data' to determine semantic relations between consecutive user queries. Our method maps queries onto concepts in linked data and searches the linked data graph for direct or indirect relations between the concepts. By comparing relations between large numbers of user queries, we identify semantic modification patterns. The application of this method to the logs of an image search engine revealed interesting usage patterns, such as that users often search for two entities sharing a property (e.g., two players from the same team). These patterns can be used to generate query suggestions. Results of preliminary experiments show that the patterns enable us to generate suggestions for more queries than a method purely based on search-log statistics.
Pilot research on the evaluation and detection of head and neck squamous cell carcinoma by Raman spectroscopy (2014)

Head and neck cancer is a broad term that covers the heterogeneous group of cancers that arise in the upper aero and digestive tract, including oral cavity, pharynx and larynx. Over 90% of this type of cancers are developed in the squamous cell epithelium of the mucosal linings and are, therefore, known as head and neck squamous cell carcinoma (HNSCC). Related with this carcinoma, current methods used for discriminating between these tumor cells and the healthy ones are slow and not specific enough or interfere with the tissue modifying it. The development of more efficient and in situ optical methodologies for HNSCC detection is required to diagnose in shorter periods. Raman spectroscopy is an emerging biophotonic tool that has greatly advanced because of steady improvements in instrumentation for excitation, data collection and in the availability of fiber optic probes. The evaluation of the viability of Raman spectroscopy for discriminating between normal and HNSCC cells by the interpretation of quantitative molecular changes was the main objective of this work. Thus, an ex vivo study with mucosa samples of healthy or carcinoma tissue of oral and pharynx cavity was analyzed to assess and quantitate the biochemical variations at the characteristic Raman peaks correspondent to DNA, amide I, amide III, phenylalanine and other proteins and lipids. With those data, three indexes were established as indicators of HNSCC. The potentiality of Raman spectroscopy for an efficient diagnosis of HNSCC was demonstrated. Copyright © 2014 John Wiley & Sons, Ltd.
Long-term renal preservation after brain death maintained with vasopressin and epinephrine (1990)

Abstract. In order to examine renal function after brain death, twenty-eight patients were randomly separated into two groups. The systemic blood pressure of ten patients was maintained with epinephrine alone (group 1). Eight of the ten patients experienced cardiac arrest within 48 h (range 6–87 h) despite the rather large dosage of epinephrine. Urine output was uncontrollable and renal function deteriorated progressively in this group. Eighteen patients were maintained with arginine vasopressin and epinephrine (group 2). Circulation was maintained with a smaller dosage of epinephrine than that given group 1 for at least 4 days (meanSD 16. 5 12. 2 days). Urine output was controlled within the normal range and serum levels of blood urea nitrogen (BUN) and creatinine were normal for 14 days. Daily creatinine clearance was more than 80 ml/min. The combined administration of arginine vasopressin and epinephrine preserved the kidneys after brain death for more than a week. This method will be of great value in renal transplantation from brain-dead organ donors.
The feasibility of reusing highway runoff for fabric dyeing: a proof of concept (2022)

Urbanization transforms many natural catchments into urban areas with highly impervious surfaces creating considerable amounts of rainfall-runoff due to reduced infiltration rate of soil. Stormwater, previously infiltrated to recharge the aquifers, is now stormwater run-off rapidly draining into receiving waters. In this research work, an attempt is made to reuse the stormwater run-off in the textile industry for sustainable development and to avoid degradation of the ecosystem of receiving water bodies. Twenty-four stormwater samples were collected from an urban highway and analyzed for pH, Temperature, Total Dissolved Solids (TDS), Total Suspended Solids (TSS), Electrical Conductivity (Ec), Hardness, Calcium (Ca), Magnesium Mg), Chloride (Cl) and Sulphate (SO4) to determine physiochemical properties of highway run-off water. After analyzing physiochemical parameters, three reactive dyes, Remazol brilliant red 6B, Remazol navy blue GG, and Remazol yellow GR, were prepared using stormwater. Washing fastness and crocking/ rubbing fastness tests were performed for performance evaluation.
Research on Improvement Algorithm of Image Edge Detection (2014)

This paper presents new theorems Stevens edge detection method based on cognitive psychology on. Firstly, based on the number of the image is decomposed into high-frequency and low-frequency information, and the high-frequency information extracted by subtracting the maximum number of images to the image after the filter, then the amount of high frequency information into psychological cognitive psychology based on Stevenss theorem. The algorithm suppression refined edge after the non-minimum, applications Pillar K-means algorithm to extract image edge. Experimental results show that: the brightness of the image is converted to the amount of psychological edge can better unify under different brightness values.
Alternative splicing of cyclin transcripts in maize endosperm (1997)

Cyclins are the regulatory subunits of cyclin-dependent protein kinases. In investigations of the expression of a cyclin gene during maize endosperm development, we detected a cyclin transcript with a 63-bp deletion in the region encoding the conserved 'cyclin box' where cyclin interacts with p34cdc2, the catalytic domain of the cyclin-dependent protein kinase. Analysis of cDNA and genomic sequences, and other observations, indicated that the deletion was caused by alternative splicing of a retained intron in the normally spliced transcript. Whereas the normally spliced cyclin RNA was mitotically functional, as indicated by its ability to promote maturation of Xenopus oocytes, the alternatively spliced transcript was unable to promote maturation. In addition to maize endosperm, the alternatively spliced cyclin was detected in apical meristem, mature leaf, root tip and mature root.
Sequential lookahead method for digital counters (1996)

In the design of synchronous digital counters the carry chain which starts from the least significant digit determines the maximum clock speed. Various schemes for implementing the carry calculation have been proposed to minimise the time of that computation. The author describes a new technique which uses additional state bits to aid in the carry calculation. This is shown to give a useful increase in clock speed over conventional combinational logic based carry lookahead techniques. The technique is also applicable to general finite state machines.
Efficient Syntheses of 1-Amido-3-aryl- and 1-Amido-3-alkylimidazo[1,5-<i>a</i>]pyridines (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTEfficient Syntheses of 1-Amido-3-aryl- and 1-Amido-3-alkylimidazo[1,5-a]pyridinesAlan R. Katritzky and Guofang QiuView Author Information Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200 [email protected]Cite this: J. Org. Chem. 2001, 66, 8, 2862–2864Publication Date (Web):March 29, 2001Publication History Received27 November 2000Published online29 March 2001Published inissue 1 April 2001https://pubs.acs.org/doi/10.1021/jo0016632https://doi.org/10.1021/jo0016632brief-reportACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views475Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cations,Cyclization,Molecular structure,Organic reactions,Pyridines Get e-Alerts
Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for <i>Arabidopsis</i> flower development (2004)

Transcription repression plays important roles in preventing crucial regulatory proteins from being expressed in inappropriate temporal or spatial domains. LEUNIG (LUG) and SEUSS (SEU) normally act to prevent ectopic expression of the floral homeotic gene AGAMOUS in flowers. LUG encodes a protein with sequence similarities to the yeast Tup1 corepressor. SEU encodes a plant-specific regulatory protein with sequence similarity in a conserved dimerization domain to the LIM-domain binding 1/Chip proteins in mouse and Drosophila. Despite the molecular isolation of LUG and SEU, the biochemical function of these two proteins remains uncharacterized, and the mechanism of AGAMOUS repression remains unknown. Here, we report that LUG and SEU interact directly in vitro and in vivo. Furthermore, LUG exhibits a strong repressor activity on several heterologous promoters in yeast and plant cells. SEU, in contrast, does not exhibit any direct repressor activity, but can repress reporter gene expression only in the presence of LUG, indicating a possible role of SEU as an adaptor protein for LUG. Our results demonstrate that LUG encodes a functional homologue of Tup1 and that SEU may function similarly to Ssn6, an adaptor protein of Tup1. We have defined the LUG/LUH, Flo8, single-strand DNA-binding protein domain of LUG as both necessary and sufficient for the interaction with SEU and two domains of LUG as important for its repressor function. Our work provides functional insights into plant transcriptional corepressors and reveals both conservation and distinctions between plant corepressors and those of yeast and animals.