gebhart/patrepeval huggingface dataset:
Rho-Mediated Regulation of TGF-β1– and FGF-2–Induced Activation of Corneal Stromal Keratocytes (2009)

Rho signaling has a significant role in the activation of keratocytes. Rho, via ROCK-independent and/or -dependent pathways differentially regulates the TGF-beta1-induced expression of alpha-SMA and TGF-beta1- and FGF-2-induced de novo expression of tenascin-C and the downregulation of alpha3(IV) collagen and KSPGs, lumican and keratocan.
DC current suppression circuit in HVDC power transmission system (2014)

To increase the popularity of HVDC power transmission system, the Multi-Terminal Direct Current (MTDC) power transmission system is expected to be installed. Since the Voltage Source Converter HVDC (VSC-HVDC) is available, the MTDC systems are much more likely to be installed soon. However, an efficient Direct Current blocking measure such as DC circuit breaker remains as the most critical hurdle to implement MTDC system. In this paper, a new DC current suppression circuit is proposed. This circuit is a kind of the semiconductor DC circuit breaker, and can be used for very quickly interrupting the DC current against the short circuit fault condition at the cost of minimum conduction loss at the normal operation. Because of the modular configuration, the proposed circuit has inherent redundancy and no need of the series-connection of the semiconductor switches and bulky surge voltage arrestor bank.
A Search for the Origins of Animals and Fungi: Comparing and Combining Molecular Data (1999)

Green plants, animals, and fungi have long held our interest as complex, largely multicellular eukaryotes of indeterminate origin. Considerable progress has now been made toward understanding the evolutionary relationships among these taxa as well as identifying their closest protistan relatives. An exclusive animal-fungal clade (the Opisthokonta) is now widely accepted based on an insertion in the protein synthesis elongation factor 1alpha (EF-1alpha) and molecular phylogenies of ribosomal RNAs and the conservative proteins actin, alpha-tubulin, beta-tubulin, and EF-1alpha. Protein data also suggest that the cellular (dictyostelid) and acellular (myxogastrid) slime molds are a close outgroup to the animal-fungal clade. Subsequent sequencing and phylogenetic analysis of EF-1alpha sequences very strongly support a monophyletic slime mold clade (the Mycetozoa or Eumycetozoa), which also includes the lesser-known protostelid slime molds. Monophyly of the opisthokont and mycetozoan clades, exclusive of green plants, is suggested by individual analyses of EF-1alpha and actin and given strong support by concatenated protein data. Neither the monophyly of the slime molds nor their close relationship to animals and fungi are consistently supported by ribosomal RNA data. Thus, it appears unlikely that any single molecule will accurately reconstruct all higher-order taxonomy.
Evaluating forecasting algorithms and stocking level strategies using discrete-event simulation (1997)

Article Free AccessEvaluating forecasting algorithms and stocking level strategies using discrete-event simulation Authors: Gregory R. Clay Perot Systems Corporation, 100 E. Big Beaver Road, Suit 400, Troy, Michigan Perot Systems Corporation, 100 E. Big Beaver Road, Suit 400, Troy, MichiganView Profile , Frank Grange Perot Systems Corporation, 5990 Greenwood Plaza Blvd., Suite 350, Englewood, CO Perot Systems Corporation, 5990 Greenwood Plaza Blvd., Suite 350, Englewood, COView Profile Authors Info & Claims WSC '97: Proceedings of the 29th conference on Winter simulationDecember 1997 Pages 817–824https://doi.org/10.1145/268437.268660Published:01 December 1997Publication History 11citation471DownloadsMetricsTotal Citations11Total Downloads471Last 12 Months37Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Cutting Edge: Recombinant <i>Listeria monocytogenes</i> Expressing a Single Immune-Dominant Peptide Confers Protective Immunity to Herpes Simplex Virus-1 Infection (2007)

The vast majority of the world's population is infected with HSV. Although antiviral therapy can reduce the incidence of reactivation and asymptomatic viral shedding, and limit morbidity and mortality from active disease, it cannot cure infection. Therefore, the development of an effective vaccine is an important global health priority. In this study, we demonstrate that recombinant Listeria monocytogenes (Lm) expressing the H-2K(b) glycoprotein B (gB)(498-505) peptide from HSV-1 triggers a robust CD8 T cell response to this Ag resulting in protective immunity to HSV infection. Following challenge with HSV-1, immune-competent mice primed with recombinant Lm-expressing gB(498-505) Ag were protected from HSV-induced paralysis. Protection was associated with dramatic reductions in recoverable virus, and early expansion of HSV-1-specific CD8 T cells in the regional lymph nodes. Thus, recombinant Lm-expressing Ag from HSV represents a promising new class of vaccines against HSV infection.
Analysis of Limit Cycle Oscillations in Digital Current-Mode Control (2006)

The objective of this paper is to show that when a dc-dc converter employs digital current mode control limit cycle oscillations may occur due to quantization of inductor current. It is also shown that unlike digital voltage-mode control a few conditions will always exist when this problem can not simply be solved by adjustment of the resolution of the digital pulse width modulator (DPWM) with respect to the resolution of the analog to digital converter (ADC). The analysis of the limit cycle oscillations in the inductor current is presented by graphical means. It indicates that a closed-loop solution to the problem is possible, if the current reference is dynamically varied. The advantage of the proposed closed-loop solution is that it does not put any constraint on the resolutions of the ADC and the DPWM. Simulations and experimental results have been presented to validate the analysis.
Inhibitory effects of Sudanese medicinal plant extracts on hepatitis C virus (HCV) protease (2000)

One hundred fifty-two methanol and water extracts of different parts of 71 plants commonly used in Sudanese traditional medicine were screened for their inhibitory effects on hepatitis C virus (HCV) protease (PR) using in vitro assay methods. Thirty-four extracts showed significant inhibitory activity (>/=60% inhibition at 100 microg/mL). Of these, eight extracts, methanol extracts of Acacia nilotica, Boswellia carterii, Embelia schimperi, Quercus infectoria, Trachyspermum ammi and water extracts of Piper cubeba, Q. infectoria and Syzygium aromaticum, were the most active (>/=90% inhibition at 100 microg/mL). From the E. schimperi extract, two benzoquinones, embelin (I) and 5-O-methylembelin (II), were isolated and found as potent HCV-PR inhibitors with IC(50) values of 21 and 46 microM, respectively. Inhibitory activities of derivatives of I against HCV-PR as well as their effects on other serine proteases were also investigated.
Models of knowledge in the assessment of postoperative pain (2010)

This article illustrates a process of knowledge development and the interrelationship between knowledge and practice using Carper's fundamental patterns of knowing. It explores two kinds of knowledge, theoretical knowledge and practical knowledge, using postoperative pain assessment as an illustration. By using their theoretical knowledge and their practical experience, nurses can maintain and develop their professional knowledge and competence.
THE BILATERAL ULNAR ARTERY INVOLVEMENT IN TYPE IV EHLERS-DANLOS SYNDROME — A CASE REPORT (2012)

Ehlers-Danlos syndrome Type IV, the vascular type, is a rare hereditary condition. Major arteries are often affected in this type. In this paper, we present the first case report in the world in which forearm compartment syndrome caused by the bilateral ulnar artery rupture in this type. Successful treatment such as incision of the forearm fascia and ligation of the ulnar artery was performed.
Working Hours Constraints and Job Duration (1992)

Infections caused by Methicillin-Resistant Staphylococcus aureus (MRSA) and Extended-Spectrum Beta-Lactamase (ESBL) producing Enterobacter cloacae are considered as major therapeutic challenge due to their multidrug-resistant (MDR) phenotype against conventional antibiotics. WLBU2 is an engineered cationic peptide with potent antimicrobial activity. This in-vitro study aimed to evaluate the effects of WLBU2 against clinical isolates of the aforementioned bacteria and assess whether synergistic effects can be achieved upon combination with conventional antibiotics. The minimum inhibitory concentrations (MICs) of antimicrobial agents against bacterial clinical isolates (n = 30/strain) were determined using the microbroth dilution assay. The minimum bactericidal concentrations (MBCs) of WLBU2 were determined from microbroth dilution (MICs) tests by subculturing to agar plates. MICs of WLBU2 were evaluated in the presence of physiological concentrations of salts including NaCl, CaCl2 and MgCl2. To identify bacterial resistance profile, MRSA were treated with Oxacillin, Erythromycin and Vancomycin, while Ceftazidime, Ceftriaxone, Ciprofloxacin and Imipenem were used against Enterobacter cloacae. Combination treatments of antibiotics and sub-inhibitory concentrations of WLBU2 were conducted when MICs indicated intermediate/resistant susceptibility. The MICs/MBCs of WLBU2 were identical for each respective bacteria with values of 0.78-6.25 μM and 1.5-12.5 μM against MRSA and Enterobacter cloacae, respectively. WLBU2 was found as salt resistant. Combination treatment showed that synergistic and additive effects were achieved in many isolates of MRSA and Enterobacter cloacae. Our data revealed that WLBU2 is a potent peptide with bactericidal activity. In addition, it demonstrated the selective advantage of WLBU2 as a potential therapeutic agent under physiological solutions. Our findings also support the combination of WLBU2 and conventional antibiotics with potential application for treatment of resistant bacteria.
Planning proton therapy of the eye (1983)

We describe a program for planning treatments of the eye with charged particle beams. Many of its features apply to treatment planning programs in general. These include the three-dimensional definition of the tumor volume and of normal structures, the possibility of delivering the treatment beam from any direction in space, the provision of arbitrary viewpoints including a "beam's eye" point of view, the design and fabrication of the field shaping aperture, the specification of the necessary beam quality (range and modulation), the calculation and display of isodose contours on any plane in space and on relevant surfaces, the identification of the extent to which normal structures are included or excluded from the beam, and the stimulation of the desired alignment film with which patient alignment can be verified.
Martial Guéroult, crítico da crítica hegeliana. Observações sobre o lugar da exegese em filosofia (1996)

We discuss in which sense it is possible to analyse the limitations of the structural reading applied to the Hegelian philosophy, namely when the latter criticizes Kant’s morality. Based on an article written by M. Guéroult about this subject, we compare on the one side his assumptions, mainly in the dianoématique, on the other side the theorethical and practical requests which guide the consequences of this critique.
Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABA<sub>A</sub> Receptors (1995)

Previous studies from this laboratory have shown that progesterone (PROG) treatment in ovariectomized rats produces an anti-anxiety response similar to that observed after the administration of prototypical anxiolytic benzodiazepine (BDZ) compounds. The PROG-induced anxiolytic response was highly correlated with an increased level of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) in the blood and brain, and was also associated with a facilitation of GABA-stimulated chloride ion (Cl-) influx in cortical synaptoneurosomes. This correlative evidence suggested that the anxiolytic effect of PROG was a result of its in vivo reduction to the neuroactive steroid, allopregnanolone. In this report, a series of studies was conducted to determine the mechanism(s) by which PROG alters behavior in animal models of anxiety. In the first experiment, ovariectomized rats were injected with PROG (1 mg/0.2 ml, SC) 4 h prior to a test in the elevated plus-maze. Some animals also received an injection of picrotoxin (0.75 mg/kg, IP), a GABAA receptor-gated Cl- channel antagonist, whereas other animals were pretreated with RU 38486 (5 mg/0.2 ml, SC), a progestin receptor antagonist. PROG elicited anxiolytic behavior in the plus-maze, an effect that was blocked by picrotoxin administration. Pretreatment with RU 38486 was not effective in altering PROG-induced anxiolytic behavior in the plus-maze. In a second experiment, the effect of PROG on behavior in the plus-maze was determined in the presence of N,N-diethyl-4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta-carboxamide (4-MA; 10 mg/0.2 ml, SC), a 5 alpha-reductase inhibitor.(ABSTRACT TRUNCATED AT 250 WORDS)
Supramolecular Structures of Novel Carbohydrate-Based Phospholipids (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSupramolecular Structures of Novel Carbohydrate-Based PhospholipidsGeoffrey S. Hird, Thomas J. McIntosh, and Mark W. GrinstaffView Author Information Department of Chemistry Paul M. Gross Chemical Laboratory Duke University, Durham North Carolina 27708 Department of Cell Biology, Duke University Medical Center Durham, North Carolina 27710 Cite this: J. Am. Chem. Soc. 2000, 122, 33, 8097–8098Publication Date (Web):August 6, 2000Publication History Received17 May 2000Revised7 July 2000Published online6 August 2000Published inissue 23 August 2000https://doi.org/10.1021/ja001653iCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views482Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (111 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Lipids,Phase transitions,Supramolecular structures and assemblies,Vesicles Get e-Alerts
Reoperation after lumbar intervertebral disc surgery (1978)

This retrospective study includes 53 patients who underwent reoperation after failure of lumbar disc surgery to relieve pain. All patients had leg pain before reoperation, which was successful in 28% of cases. Most clinical features, such as persistence or mode of recurrence of pain, radicular quality of pain, positive straight-leg raising, and myelographic root sleeve defects, were not helpful in predicting successful and unsuccessful reoperations. However, a significantly larger percentage of women than men had successful reoperations. Patients who had past or pending compensation claims, who had sensory loss involving more than one dermatome, or who failed to have myelographic dural sac indentations resembling those caused by a herniated disc did poorly with reoperation. A very convincing myelographic defect appears to be needed to justify reoperation at a previously unoperated location. Excision of scar alone or dorsal rhizotomy was of no avail in these cases.
‘‘Diamondlike’’ carbon films: Optical absorption, dielectric properties, and hardness dependence on deposition parameters (1985)

An rf plasma deposition system was used to prepare amorphous ‘‘diamondlike’’ carbon films. The source gases for the rf system include methane, ethylene, propane, and propylene, and the parameters varied were power, dc substrate bias, and postdeposition anneal temperature. Films were deposited on various substrates. The main diagnostics were optical absorption in the visible and in the infrared, admittance as a function of frequency, hardness, and Auger and ESCA spectroscopy. Band gap is found to depend strongly on rf power level and band gaps up to 2.7 eV and hardness up to 7 Mohs were found. There appears to be an inverse relationship between hardness and optical band gap.
Concurrent decrease in IL-10 with development of immune-related adverse events in a patient treated with anti-CTLA-4 therapy. (2008)

The cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule on T cells acts to maintain homeostasis by regulating the proliferation of recently activated T cells. Blockade of CTLA-4 by anti-CTLA-4 antibody enhances T cell responses and has elicited significant tumor regression in some cancer patients. Clinical trials are ongoing to investigate the efficacy of anti-CTLA-4 antibody as a cancer therapeutic. Reports from several clinical trials have documented the occurrence of adverse events in patients treated with anti-CTLA-4 antibody which have some similarities with autoimmune conditions and have been termed immune-related adverse events (irAEs). Most irAEs are reversible with corticosteroid therapy. Some investigators suggest that irAEs occur in the same patients who have anti-tumor responses as a result of the anti-CTLA-4 antibody. Immunologic mechanisms to explain why irAEs occur in some patients have not been reported. Here we report that bladder cancer patients treated with anti-CTLA-4 antibody have increased levels of the Th1 cytokine IFN-gamma detected in plasma samples. Although IFN-gamma is a potent anti-tumor and inflammatory cytokine, increased levels of IFN-gamma were not associated with irAEs in our patients. However, in one patient who experienced an irAE consisting of ischemic papillopathy and optic neuritis, we documented high pre-therapy levels of the Th2 cytokine IL-10 which decreased after treatment with anti-CTLA-4 antibody. The decrease in plasma IL-10 concentration coincided with the patient's irAE. We propose that decreased levels of IL-10 after treatment with anti-CTLA-4 therapy may be responsible for irAEs in some patients and needs to be further investigated in larger studies.
RANCANGAN PENGOLAHAN BATU ANDESIT UNTUK MEMENUHI STANDAR INDUSTRI INDONESIA (2021)

Pembangunan infrastruktur yang terus meningkat memberi pengaruh pada kebutuhan material konstruksi. Material konstruksi yang dibutuhkan salah satunya batu split. Batu split dapat berasal dari andesit. Cadangan andesit di daerah Tanjung Enim, perlu dimanfaatkan sebagai material konstruksi. Akan tetapi, berdasarkan penelitian sebelumnya, produk pengolahan dari pabrik peremukan batuan andesit di PT Bukit Asam, Tbk. belum memenuhi standar sebagai material konstruksi beton. Penelitian ini bertujuan untuk mendesain alur pengolahan baru sehingga kualitas hasil pengolahan dapat memenuhi kualitas standar industri Indonesia serta menganalisis biaya yang akan dikeluarkan dari alur baru tersebut. Penelitian dimulai dengan melakukan perancangan serta menghitung persentase ukuran produk hasil pengolahan dari unit crushing plant yang dilakukan menggunakan kurva closed side setting jaw crusher. Selanjutnya dihitung total biaya pengolahan dan memperkirakan akibat yang akan diperoleh perusahaan apabila menginvestasikan alat crushing plant baru. Berdasarkan penelitian didapatkan bahwa ukuran produk pemecahan sangat beragam, sehingga pada alur pengolahannya diperlukan secondary crusher. Batuan andesit akan direduksi ukurannya dari 700 mm menjadi 200 mm dengan menggunakan primary jaw crusher. Kemudian direduksi kembali menjadi 70 mm menggunakan secondary jaw crusher. Penambahan deck pada vibrating screen juga diperlukan agar dihasilkan produk dengan empat fraksi yakni 0-10mm, 10-20mm, 20-50mm, dan 50-70mm. Biaya pengolahan yang akan dikeluarkan dari alur tersebut adalah Rp 1.490.018,74/jam. Apabila perusahaan melakukan investasi alat crushing plant baru maka, perusahaan akan memperoleh keuntungan sebesar Rp 2.271.582.678/bulan. Hasil penelitian menunjukkan perlunya pembangunan unit crushing plant baru agar produk hasil pengolahan memenuhi standar. Pembangunan unit crushing plant ini juga dinyatakan layak secara ekonomi.
Round Trip Latency Based Authentication Scheme in Fog-Enabled Cloud Computing System (2019)

In fog-enabled cloud computing framework, one of the most challenges is security promises due to the compromised passwords. To overcome this issue, different multifactor authentication schemes have been developed that requires additional authentication credentials along with the standard password to authenticate the login. Among those schemes, Communication Latency-based Authentication Scheme (CLAS) increases the protection of conventional web authentication schemes by leveraging the Round Trip network communication Latency (RTL) between clients and authenticators together with standard password. It uses RTL of clients to secure against password compromise. On the other hand, it can support compromise of either the password or the profiled location of a user. This makes it susceptible to same location attacks. As a result, an integration of additional profiling features is needed to attain more robust and flexible defense against password compromise. Hence in this paper, an extended CLAS is proposed that mainly investigates the mobility and same location challenges in CLAS. Initially, the legitimate login failures are solved by handling both selective and arbitrary mobility of users. For selective mobility case, CLAS generates an individual profile for each location and the user may be granted access if his/her real-time login profile matches any of the stored reference profiles. For arbitrary mobility case, CLAS is integrated with two-factor authentication mechanism to authenticate the user. In addition, the defense against Mimic attacks is improved by utility metric-based location anonymization and obfuscation of RTL algorithms. By using these algorithms, the user’s locations are anonymized and the values of RTL are obfuscated to defend against user compromise attempts for impersonating the RTL by getting nearer to the user location. Moreover, a keystroke dynamics measure is introduced with obfuscated RTL measures to effectively defend the same location attacks. This technique alleviates the potential impacts of network instabilities on RTL measurements. As well, it increases the authentication sample space and so improves the security guarantee of CLAS. Finally, the simulation outcomes illustrate that an extended CLAS has the ability to reduce both false positive and false negative rates.