gebhart/patrepeval huggingface dataset:
Female Fecundity as a Function of Age (1982)

Fecundity has been reported to decline in women over 30 years of age. It is not known whether the decrease in fecundity is biologic or simply the consequence of diminished sexual activity. Artificial insemination with donor semen (AID) offers an opportunity to control certain variables in the study of female fecundity over time. 2193 nulliparous women who were receiving AID from 1973-80 at the Centres d'Etude et de Conservation du Sperme Humain (CECOS) and whose husbands were totally sterile were studied. The women were divided into 4 age groups: 25 years old or younger (n=371), 26-30 (n=1079), 31-35 (n=599), and 35 or older (n=144). At the end of the study period, the women were categorized into 4 groups, depending on the outcome: success (all pregnancies occurring during the study period), lost to follow-up (if the result of the last AID cycle was unknown), open case (result of last AID cycle was known but the next insemination procedure had not yet taken place), and dropout (discontinued treatment). The cumulative success rates were calculated ater 12 cycles with the life table technique adapted to AID as if there were no dropouts (theoretical cumulative rates). The Mantel-Haenzel test was used to compare the curves obtained from the cumulative rate as a function of the number of treatment cycles for the various age groups. The 4 curves differed significantly (chi-square=15.72, with 3 degrees of freedom; p0.01). The curves for the 2 age groups under 30 were very similar. Overall, the study shows that a decrease in fecundability (conception rate per cycle) as a function of a woman's age is slight but significant after 30 years of age and marked after 35 years. The probability of success of AID for 12 cycles declined to 61% (from 73% for those under 31 years old) for the 31-35 age group (p0.03) and to 54% (from 74% for those under 31 years old) for those over 35 (p0.001). 2 major problems encountered in studying variations in fecundity as a function of a woman's age are: 1) the need to separate the effect of the woman's age from associated variables such as coital pattern and husband's age, and 2) the woman's age itself, which could result in bias, since time introduces a type of selection. AID may provide the best means of minimizing the effects of associated variables and sources of bias.
Deformation and structural stability of layered plate microstructures subjected to thermal loading (2002)

We study the deformation and stability of gold-polysilicon MEMS plate microstructures fabricated by the MUMPS surface micromachining process and subjected to uniform temperature changes. We measured, using an interferometric microscope, full-field deformed shapes of a series of square and circular gold (0.5 /spl mu/m thick)/polysilicon (1.5 /spl mu/m thick) plate microstructures with characteristic lengths l (square side length and circle diameter) ranging from l=150 to 300 /spl mu/m. From these measurements we determined the pointwise and average curvature of the deformed plates. Although the curvature generally varies with position, the deformation response of the plates can be broadly characterized in terms of the spatial average curvature as a function of temperature change. In terms of this, three deformation regimes were observed: (i) linear thermoelastic response independent of plate size; (ii) geometrically nonlinear thermoelastic response that depends on plate size; and (iii) bifurcations in the curvature-temperature response that also depend on plate size. We modeled the deformation response both analytically and with the finite element method; in the former we assume spatially constant curvature, while in the latter, we relax this assumption. Good qualitative and quantitative agreement is obtained between predictions and measurements in all three deformation regimes, although the details of bifurcation are less accurately predicted than the linear and nonlinear response. This is attributed to their strong sensitivity to slight imperfections, which is discussed in some detail. Good agreement is also obtained between measurements and predictions of the spatial nonuniformity of the curvature across the plate. Although it is not the focus of this study, the predictions, when coupled with curvature measurements, can be used inversely to determine elastic and thermal expansion properties of the materials in a layered plate microstructure.
N,N'-bis(2-hydroxybenzyl)-1-(4-bromoacetamidobenzyl)-1,2-ethylene-diamine-N,N'-diacetic acid: a new bifunctional chelate for radio-labeling antibodies (1990)

N,N'-Bis(2-hydroxybenzyl)-1-(4-bromoacetamidobenzyl)-1,2 -ethylenediamine-N,N'-diacetic acid (Br phi HBED) was synthesized to bind trivalent metals with high stability constants and to bifunctionally link the radiometal with antibodies (Ab). This ligand has advantages over our previously reported N-(2-hydroxy-3,5-dimethylbenzyl)-N'-(2-hydroxy-5- bromoacetamidobenzyl)ethylenediamine-N,N'-diacetic acid (BrMe2HBED). Br phi HBED has the protein coupling group BrCH2CONH removed from the sterically hindered ring position with the addition of a benzyl group in the linker arm; this provides further distance between the protein and the chelate. We have also observed that the chelate was more stable than BrMe2HBED, so it can be stored longer without loss of observed chemical properties. The improved chelate design allows for more rapid radiolabeling with [111In]indium citrate (1 h at room temperature) with higher radiochemical yields. Br phi HBED was conjugated with an anticolorectal carcinoma monoclonal antibody (1A3) where radiolabeling yields of 75-90% were obtained and the antibody retained its immunoreactivity (ca. 90%) under all labeling conditions studied. Biodistribution studies in a hamster transplanted tumor (GW39) model demonstrated a high tumor uptake when compared to those of 125I-1A3 or 111In-DTPA cyclic anhydride-1A3. Blood clearance of 111In-Br phi HBED-1A3 was rapid and combined with its high target uptake has higher target to nontarget ratios in vivo at various time intervals when compared with that of 1A3 radiolabeled with either 111In-DTPA cyclic anhydride or 125I.
Joint automotive radar-communications waveform design (2017)

The paper studies the problem of waveform design for a joint Radar-Communications (RadComms) system in an automotive setting characterized by a multitarget environment. The envisaged joint waveform allows exploitation of existing infrastructure to support additional functionalities. In this contribution, an automotive radar employing Phase Modulated Continuous Waveform (PMCW) is considered wherein, the transmission of communications bits is additionally facilitated. Particularly, the RadComms system is enabled by the transmission of Differential Phase Shift Keying (DPSK) communications symbols, each symbol modulated by the PMCW sequence. Further, the receiver processing includes demodulation of the communication symbols in addition to the extraction of the radar parameters — range, Angles of Arrival (AoA) and Doppler returns of the targets. In particular, FFT and subspace-based methods are proposed for estimating the radar parameters which are subsequently used in the demodulation of the communication symbols using diversity combining techniques. The performed study demonstrates the impact of the joint set-up on the two systems. It also highlights the effect of system parameters on the performance of receiver algorithms and the trade-off between the FFT and sub-spaced based processing.
Construction of centered shortest‐path trees in networks (1983)

Abstract Many researchers in the area of distributed networks have found it convenient to assume the existence of a facility for routing broadcast messages to all the nodes in the network. We are investigating an approach called center‐based forwarding which routes messages via the branches of the shortest‐path tree for some node near the center of the network. In this article we show that this approach results in broadcasts that finish with low delay; we then explain how to construct centered trees in a loosely coupled network environment.
Adversarial Training: embedding adversarial perturbations into the parameter space of a neural network to build a robust system (2019)

Adversarial training, in which a network is trained on both adversarial and clean examples, is one of the most trusted defense methods against adversarial attacks. However, there are three major practical difficulties in implementing and deploying this method - expensive in terms of extra memory and computation costs; accuracy trade-off between clean and adversarial examples; and lack of diversity of adversarial perturbations. Classical adversarial training uses fixed, precomputed perturbations in adversarial examples (input space). In contrast, we introduce dynamic adversarial perturbations into the parameter space of the network, by adding perturbation biases to the fully connected layers of deep convolutional neural network. During training, using only clean images, the perturbation biases are updated in the Fast Gradient Sign Direction to automatically create and store adversarial perturbations by recycling the gradient information computed. The network learns and adjusts itself automatically to these learned adversarial perturbations. Thus, we can achieve adversarial training with negligible cost compared to requiring a training set of adversarial example images. In addition, if combined with classical adversarial training, our perturbation biases can alleviate accuracy trade-off difficulties, and diversify adversarial perturbations.
Convergence analysis of a data echo canceller with a stochastic gradient adaptive FIR filter using the sign algorithm (1995)

Under the assumption that the "errors at the taps" are Gaussian distributed, a new set of recurrence formulae is derived for calculating theoretical convergence process of a data echo canceller equipped with an FIR filter that is adaptively controlled by using the "stochastic gradient sign algorithm" with a binary and white process as the filter input. Convergence curves for the mean squared residual echo based on the recurrence formulae show an excellent agreement with those obtained by simulation. Approximate recurrence formulae that yield a useful, though less accurate, estimation of the residual echo convergence are also proposed. Furthermore, a closed-form solution to the approximate recurrence formulae is derived. And finally, probability density function of the residual echo is depicted as it changes its shape as the echo canceller converges.
Surgical treatment of incisional hernia (2002)

Open suture repair for incisional hernia carries an unacceptably high recurrence rate. The results of open mesh and laparoscopic mesh techniques are encouraging. There is scope for a large multicentre randomized clinical trial to compare laparoscopic and open mesh repair.
Thinking about the God of the Poor: Questions for Liberation Theology from Process Thought (1989)

Journal Article Thinking about the God of the Poor: Questions for Liberation Theology from Process Thought Get access Delwin Brown Delwin Brown Delwin Brown is Harvey H. Potthoff Professor of Christian Theology at Iliff School of Theology, 2201 S. University Blvd., Denver, CO 80210. Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume LVII, Issue 2, Summer 1989, Pages 267–281, https://doi.org/10.1093/jaarel/LVII.2.267 Published: 01 July 1989
Formation of Carbon Nanotube Based Gears: Quantum Chemistry and Molecular Mechanics Study of the Electrophilic Addition of o-Benzyne to Fullerenes, Graphene, and Nanotubes (1997)

Considerable progress has been made in recent years in chemical functionalization of fullerene molecules. In some cases, the predominant reaction products are different from those obtained (using the same reactants) from polycyclic aromatic hydrocarbons (PAHs). One such example is the cycloaddition of o-benzyne to C60. It is well established that benzyne adds across one of the rings in naphthalene, anthracene and other PAHs forming the [2+4] cycloaddition product (benzobicyclo[2.2.2.]-octatriene with naphthalene and triptycene with anthracene). However, Hoke et al demonstrated that the only reaction path for o-benzyne with C60 leads to the [2+2] cycloaddition product in which benzyne adds across one of the interpentagonal bonds (forming a cyclobutene ring in the process). Either reaction product results in a loss of aromaticity and distortion of the PAH or fullerene substrate, and in a loss of strain in the benzyne. It is not clear, however, why different products are preferred in these cases. In the current paper, we consider the stability of benzyne-nanotube adducts and the ability of Brenner's potential energy model to describe the structure and stability of these adducts. The Brenner potential has been widely used for describing diamondoid and graphitic carbon. Recently it has also been used for molecular mechanics and molecular dynamics simulations of fullerenes and nanotubes. However, it has not been tested for the case of functionalized fullerenes (especially with highly strained geometries). We use the Brenner potential for our companion nanogear simulations and believe that it should be calibrated to insure that those simulations are physically reasonable. In the present work, Density Functional theory (DFT) calculations are used to determine the preferred geometric structures and energetics for this calibration. The DFT method is a kind of ab initio quantum chemistry method for determining the electronic structure of molecules. For a given basis set expansion, it is comparable in accuracy to the MP2 method (better than Hartree Fock, but less accurate than more extensive electron correlation methods such as MP4 or CCSD). However, for systems with large numbers of basis functions it more efficient than any other methods that include electron correlation effects. In this presentation we show the results of DFT calculations for the reaction of benzyne with naphthalene, C60, and nanotube models. We compare energies for [2+2] and [2+4] cycloaddition products. The preferred products for the naphthalene and C60 reactions have been determined by experiment and, thus, these cases serve as a validation of our quantum chemical approach. We also compare the DFT and Brenner potential results. Finally we can predict the likelihood of reaction between benzyne and nanotubes.
Endothelial protein C receptor–expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver (2010)

Hematopoietic stem cells (HSCs) are maintained in specialized niches in adult bone marrow. However, niche and HSC maintenance mechanism in fetal liver (FL) still remains unclear. Here, we investigated the niche and the molecular mechanism of HSC maintenance in mouse FL using HSCs expressing endothelial protein C receptor (EPCR). The antiapoptotic effect of activated protein C (APC) on EPCR(+) HSCs and the expression of protease-activated receptor 1 (Par-1) mRNA in these cells suggested the involvement of the cytoprotective APC/EPCR/Par-1 pathway in HSC maintenance. Immunohistochemistry revealed that EPCR(+) cells were localized adjacent to, or integrated in, the Lyve-1(+) sinusoidal network, where APC and extracellular matrix (ECM) are abundant, suggesting that HSCs in FL were maintained in the APC- and ECM-rich perisinusoidal niche. EPCR(+) HSCs were in a relatively slow cycling state, consistent with their high expression levels of p57 and p18. Furthermore, the long-term reconstitution activity of EPCR(+) HSCs decreased significantly after short culture but not when cocultured with feeder layer of FL-derived Lyve-1(+) cells, which suggests that the maintenance of the self-renewal activity of FL HSCs largely depended on the interaction with the perisinusoidal niche. In conclusion, EPCR(+) HSCs resided in the perisinusoidal niche in mouse FL.
Coherent phonon detection from ultrafast surface vibrations (1992)

Using an optical technique ultrafast vibrations of the surface of thin opaque films in the 0.1-THz range have been directly observed in the time domain. We propose a new type of phonon detection by monitoring the surface velocity, and demonstrate an exceptional sensitivity to atomic-scale inhomogeneities by observing an anomalous reflection from a buried film of monolayer order in thickness.
Sparse 3D convolutional neural networks (2015)

We have implemented a convolutional neural network designed for processing sparse three-dimensional input data. The world we live in is three dimensional so there are a large number of potential applications including 3D object recognition and analysis of space-time objects. In the quest for efficiency, we experiment with CNNs on the 2D triangular-lattice and 3D tetrahedral-lattice.
A graph-based approach to API usage adaptation (2010)

Reusing existing library components is essential for reducing the cost of software development and maintenance. When library components evolve to accommodate new feature requests, to fix bugs, or to meet new standards, the clients of software libraries often need to make corresponding changes to correctly use the updated libraries. Existing API usage adaptation techniques support simple adaptation such as replacing the target of calls to a deprecated API, however, cannot handle complex adaptations such as creating a new object to be passed to a different API method, or adding an exception handling logic that surrounds the updated API method calls.This paper presents LIBSYNC that guides developers in adapting API usage code by learning complex API usage adaptation patterns from other clients that already migrated to a new library version (and also from the API usages within the library's test code). LIBSYNC uses several graph-based techniques (1) to identify changes to API declarations by comparing two library versions, (2) to extract associated API usage skeletons before and after library migration, and (3) to compare the extracted API usage skeletons to recover API usage adaptation patterns. Using the learned adaptation patterns, LIBSYNC recommends the locations and edit operations for adapting API usages. The evaluation of LIBSYNC on real-world software systems shows that it is highly correct and useful with a precision of 100% and a recall of 91%.
Pharmacokinetics and concentrations of ceftiofur sodium in body fluids and endometrium after repeated intramuscular injections in mares (1993)

Each of 5 healthy mares was given 5 consecutive IM injections of ceftiofur sodium (2 mg/kg of body weight; 50 mg/ml) at 12-hour intervals. Ceftiofur concentrations were measured serially in serum, synovial fluid, peritoneal fluid, and urine, and were measured in CSF and endometrial tissue after the fifth dose. Mean elimination rate constant was 0.354 +/- 0.101 h-1 and elimination half-life was 2.49 +/- 0.49 hour. Mean serum ceftiofur concentrations peaked approximately 1 hour after each injection. The highest mean ceftiofur concentration was 5.09 micrograms/ml at 1 hour after the fifth dose for serum, 3.02 micrograms/ml at 2 hours after the fifth dose for synovial fluid, and 3.23 micrograms/ml at 4 hours after the fifth dose for peritoneal fluid. Mean urine concentrations reached 15.72 micrograms/ml at 1 hour after the fifth dose. Ceftiofur was not detected in CSF or endometrial tissue. None of the mares had adverse reactions to the drug.
A storeless model of aliasing and its abstractions using finite representations of right-regular equivalence relations (2003)

The problem of interference and aliasing in programming languages with structured, dynamically allocated data is studied. The author starts from a novel semantic model of data aliasing, then elaborates new results in formal language theory in order to represent its invariants, and finally uses these results to derive an efficient and online algorithm for statically determining dynamic aliasing properties of structured data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Visualization of primordial germ cells in vivo using GFP-nos1 3'UTR mRNA (2006)

In some teleost fish, primordial germ cells (PGCs) inherit specific maternal cytoplasmic factors such as vasa and nanos 1 (nos1) mRNA. It has been shown that the 3'untranslated regions (UTRs) of vasa and nos1 have critical roles for stabilization of these RNAs in zebrafish PGCs. In this study, to determine whether this role of the nos 1 3'UTR is conserved between teleost species, we injected artificially synthesized mRNA, combining green fluorescent protein (GFP) and the zebrafish nos 1 3'UTR (GFP-nos 1 3'UTR mRNA), into the fertilized eggs of various fish species. The 3'UTR of the Oryzias latipes vasa homologue (olvas ) mRNA was assayed in the same manner. We demonstrate that the PGCs of seven teleost species could be visualized using GFP-nos 1 3'UTR mRNA. GFP-olvas 3'UTR mRNA did not identify PGCs in herring or loach embryos, but did enable visualization of the PGCs in medaka embryos. Our results indicate that the 3'UTR of the zebrafish nos1 mRNA can promote maintenance of RNAs in the PGCs of different fish species. Finally, we describe and compare the migration routes of PGCs in seven teleost species.
The IDE as a scriptable information system (2016)

Software engineering is extremely information-intensive. Every day developers work with source code, version repositories, issue trackers, documentation, web-based and other information resources. However, three key aspects of information work lack good support: (i) combining information from different sources; (ii) flexibly presenting collected information to enable easier comprehension; and (iii) automatically acting on collected information, for example to perform a refactoring. Poor support for these activities makes many common development tasks time-consuming and error-prone. We propose an approach that directly addresses these three issues by integrating a flexible query mechanism into the development environment. Our approach enables diverse ways to process and visualize information and can be extended via scripts. We demonstrate how an implementation of the approach can be used to rapidly write queries that meet a wide range of information needs.
Approach to failed spinal anaesthesia for caesarean section (2018)

Failure of spinal anaesthesia for caesarean section may have deleterious consequences for the mother as well as the newborn baby. In this article, we discuss the mechanisms of failure of spinal anaesthesia as well as the approach to a failed block. We performed a literature search in Google Scholar, PubMed, and Cochrane databases for original and review articles concerning failed spinal anaesthesia and caesarean section. Strategies for a failed spinal anaesthetic include manoeuvers to salvage the block, repeating the block, epidural anaesthesia or a combined spinal-epidural (CSE) technique, or resorting to general anaesthesia. Factors influencing the choice of these alternative options are discussed. A "failed spinal algorithm" can guide the anaesthesiologist and help reduce morbidity and mortality.