gebhart/patrepeval huggingface dataset:
Abstract 5397: Crocetin, a carotenoid compound derived from Saffron, enhances antitumor effects of paclitaxol and cisplatin in pancreatic cancer (2010)

Abstract Pancreatic cancer is the fourth leading cause of cancer deaths in the United States and no significant treatment is at present available. Although there are an increasing number of therapeutic options available for patients with advanced disease, their efficacy is time limited and non-curative. Presently approximately 50-60% of cancer patients in the United States utilize therapies derived from plants, herbs, flowers, or nutrients (complementary and alternative medicine [CAM]), exclusively or concurrently with their traditional therapies such as chemotherapy or radiation therapy. One such CAM therapy is “crocetin”, a carotenoid compound isolated from the saffron plant. Recent studies demonstrated that crocetin has a significant antitumorigenic effect in both in vitro and in vivo on pancreatic cancer. Two conventional chemotherapeutic agents, paclitaxol (a microtubule-targeted agent) and cisplatin (a platinum based anticancer drug binds to DNA), have been demonstrated significant reduction of growth and proliferation in pancreatic cancer. Therefore, the aim of the series of experiments was to determine whether crocetin enhances paclitaxol or cisplatin induced proliferation in pancreatic cancer. MIA-PaCa-2 and BxPC3 cells were treated with crocetin and paclitaxol or cisplatin together at different doses and a proliferation assay was utilized using Click-it Edu flurorometric assay. Paclitaxol or cisplatin alone at higher doses (50-100nM) inhibited proliferation in both MIA PaCa2 and BxPC3 cells but crocetin (200μM) in combination of paclitaxol or cisplatin showed significant additive effect even at lower doses (10 and 25nM) of paclitaxol or cisplatin. The combinational effect is more pronounced in BxPC3 cells. Paclitaxol or cisplatin alone at higher doses (50-100nM) stimulated apoptosis using Deadend flurorometric TUNEL apoptosis assay in MIA PaCa2 and BxPC3 cells and apoptosis is more pronounced at lower doses in combination with crocetin. This study indicated that crocetin in combination with lower doses of paclitaxol or cisplatin inhibited proliferation and stimulated apoptosis in pancreatic cancer. The antitumorigenic effect is more pronounced in BxPC3 cells and paclitaxol is more effective than cisplatin at lower doses in combination with crocetin. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5397.
<title>Fixed and wearable acoustic counter-sniper systems for law enforcement</title> (1999)

BBN has developed flexible counter-sniper technology capable of shooter and bullet trajectory localization using fixed, vehicle-mounted, and/or body-worn microphone sensors. The proof of principle (POP) systems developed are accurate, low-cost, lightweight, and easy to install and use. The use of both supersonic bullet shock waves, and/or the muzzle blast, allows detection and localization of shooters with intentional or accidental muzzle blast suppression, or with subsonic rounds. This makes the system capable of finding shooters firing from within buildings or vehicles. It also requires fewer sensor installations per unit area and increases system robustness to the noise and reverberation present in urban settings. In this paper we first summarize the current POP system hardware and software configurations and show the results of government testing in urban and rural environments for military applications. Following this, cost and performance issues for urban law enforcement applications are presented, and performance predictions for various system configurations in an urban street monitoring scenario are given.
Measurement of Potential Alpha Energy Concentration of Radon and Thoron Daughters Using an Electret Dosemeter (1983)

Measurement of Potential Alpha Energy Concentration of Radon and Thoron Daughters Using an Electret Dosemeter Get access P. Kotrappa, P. Kotrappa Search for other works by this author on: Oxford Academic PubMed Google Scholar S.K. Dua, S.K. Dua Search for other works by this author on: Oxford Academic PubMed Google Scholar P.C. Gupta, P.C. Gupta Search for other works by this author on: Oxford Academic PubMed Google Scholar N.S. Pimpale, N.S. Pimpale Search for other works by this author on: Oxford Academic PubMed Google Scholar A.H. Khan A.H. Khan Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 5, Issue 1, 1 July 1983, Pages 49–56, https://doi.org/10.1093/oxfordjournals.rpd.a082672 Published: 01 July 1983
Synthesis of ultrabright nanoporous fluorescent silica discoids using an inorganic silica precursor (2011)

The templated sol-gel synthesis of ultrabright fluorescent nanoporous silica particles based on the use of organic silica sources has previously been reported. The use of organosilanes as the main silica precursors has a number of issues, in particular, the low robustness of the synthesis due to instability of the organic silica source. Here we report on a novel synthesis of ultrabright fluorescent nanoporous silica discoids (a specific shape in-between the sphere and disk) of 3.1 ± 0.7 microns in size, which were prepared using a stable inorganic sodium silicate silica source. Organic fluorescent dye Rhodamine 6G (R6G) was physically (non-covalently) entrapped inside cylindrical nanochannels of ∼4-5 nm in diameter. In contrast to the synthesis with organic silica precursors, the obtained particles showed an excessive leakage of dye. To prevent this leakage, we modified the synthesis by adding a small amount of a secondary silica source. The synthesized particles show virtually no leakage, high photostability, and a brightness equivalent to the fluorescence of up to 7 × 10(7) free R6G molecules. This is about 7 times higher than the fluorescent brightness of particles of the same size made of CdSe/ZnS quantum dots, and 420 times higher than the brightness of the same volume of aqueous solution of free R6G dye.
Processing Aluminum Nitride‐Silicon Carbide Composites via Polymer Infiltration and Pyrolysis of Polymethylsilane, a Precursor to Stoichiometric Silicon Carbide (1999)

AlN‐SiC‐particle‐reinforced composites have been prepared at lessthan equal to1400°C using submicrometer AlN, ‐325 mesh alpha‐SiC particles, and polymethylsilane (PMS; ‐(CH 3 SiH) n ‐) via a polymer infiltration and pyrolysis (PIP) process. PMS is an organometallic SiC polymer precursor that can be modified with 16 wt% cross‐linking aid to provide mPMS. mPMS converts to nanocrystalline β‐SiC with >80% ceramic yield (1000°C in argon) with some excess (<5 wt%) graphitic carbon. mPMS has been used successfully as a nonfugitive binder for AlN‐SiC compacts. Densities of 2.5 versus 2.1 g/cm 3 have been obtained after nine PIP cycles for disk‐shaped compacts formulated with and without mPMS binder, respectively. alpha‐SiC seeds crystallization of β‐SiC derived from mPMS at temperatures as low as 1000°C. Some evidence suggests that AlN‐SiC solid solutions form at particle/matrix interfaces.
Development of Improved Materials for Environmental Applications:  Nanocrystalline NaY Zeolites (2005)

Two nanocrystalline NaY samples were synthesized with Si/Al ratios of 1.8 and crystal sizes of 23 and 50 nm, respectively. The synthesized NaY zeolites were characterized by powder X-ray diffraction, scanning electron microscopy, nitrogen adsorption isotherms, silicon solid-state magic angle spinning NMR and FTIR spectroscopy. A commercial NaY sample was analogously characterized for comparison with the synthesized nanocrystalline NaY. FTIR spectroscopy of adsorbed pyridine was used to elucidate the adsorption sites on the different NaY samples. More Brønsted acid sites and more silanol sites were detected on the nanocrystalline NaY zeolites, relative to the commercial NaY. The nanocrystalline NaY exhibited increased adsorption capacities for representative pollutant molecules, such as toluene (approximately 10%) and nitrogen dioxide (approximately 30%), relative to commercial NaY. Functionalization of nanocrystalline NaY was examined as a method for tailoring the properties of nanocrystalline zeolites for specific environmental applications through the control of zeolite properties, such as hydrophobicity.
Malignancy associated changes in epithelial cells of buccal mucosa: a potential cancer detection test. (2005)

The presence of MACs in buccal mucosa cells offers the potential for developing a new noninvasive cancer screening test.
ChemInform Abstract: Spectroscopic Analysis of the Interaction of Human Serum Albumin with Tricationic Phosphorus Porphyrins Bearing Axial Pyridinio Groups (2014)

Abstract Review: 37 refs.
Multi-Beam Transmit Receive Module for Use and SGLS Band Satellite Links (2003)

The development of a low cost Transmit-Receive module (T/R) for the next generation of Phase Array Antennas for the Air Force Satellite Control Network has been achieved. The T/R module consists of dual transmit channels each capable of 30 dBm output power, a 4-Bit phase control and a 4-Bit amplitude control. In addition, beam switching and on board digital control has been implemented. The dual receive channels exhibit a 2 dB Noise Figure associated with a gain of 30 dB per channel. Each channel exhibits four bit phase shift and five-bit amplitude control. In addition to the control functions, built-in test circuits have been incorporated to monitor the health and status of the RF devices. This function utilizes a micro-controller to output digital data for each of the power and low noise amplifiers on command, via AID converters. The bandwidth of the T/R module has been increased by a factor to encompass both the Unified S-Band (USB) and Satellite Ground Link System (SGLS). The transmit-receive functions are combined at the output via a ceramic resonator diplexer comprised of a bandpass-band stop filter. The control of the T/R module is conducted via a single Field Programmable Gate Array (FPGA) through a GPIB controller. The T/R module has been designed to meet the cost objective for an array with 55000 T/R modules. To this end the paper will detail the performance and innovative methods used to achieve the price performance goals.
Unique role of dimeric carbon precursors in graphene growth by chemical vapor deposition (2021)

Chemical vapor deposition has emerged as a promising approach for high-quality graphene synthesis. Graphene quality, including the defect density, the size of monocrystal domains, and the number of layers, depend on the growth conditions. The main experimental parameters include temperature, metal catalyst composition, growth atmosphere, and gaseous dynamics in the reaction chamber. Here we show, that even for the same growth conditions, simply changing carbon source from methane to ethane or acetylene yields drastically different growth mode that allows the production of single-crystal-like graphene on a polycrystalline metal foil substrate. This new single crystal growth mechanism does not require local supply of carbon precursors or special single crystal catalytic substrate that were introduced earlier. We assign the observed differences in the growth mechanism to formation of stable and mobile dimeric C2Hx intermediate species from ethane and acetylene, in contrast to less mobile CHx and C3Hx species formed from methane and propane.
Thin films of calixarenes for quadratic nonlinear optics (1993)

Organic molecules with π electron systems and asymmetrical charge distribution are interesting tor use in quadratic nonlinear optics. Calix[4]arenes are cyclophanes that consist of four phenol moieties connected by methylene bridges. Functionalization of these phenols allows the combination of four D-π–A units within a single molecule. The increase in the number of D-π-A systems in a calix[4]arene molecule is accompanied by an enhancement of the molecular hyperpolarizability and the dipole moment and by a blue shift of the charge-transfer absorption band. Different substituted calix[4Jarene compounds have been synthesized and examined.
Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity (2015)

FGF receptors (FGFR) are attractive candidate targets for cancer therapy because they are dysregulated in several human malignancies. FGFR2 and FGFR3 can be inhibited potentially without disrupting adult tissue homeostasis. In contrast, blocking the closely related FGFR1 and FGFR4, which regulate specific metabolic functions, carries a greater safety risk. An anti-FGFR3 antibody was redesigned here to create function-blocking antibodies that bind with dual specificity to FGFR3 and FGFR2 but spare FGFR1 and FGFR4. R3Mab, a previously developed monospecific anti-FGFR3 antibody, was modified via structure-guided phage display and acquired additional binding to FGFR2. The initial variant was trispecific, binding tightly to FGFR3 and FGFR2 and moderately to FGFR4, while sparing FGFR1. The X-ray crystallographic structure indicated that the antibody variant was bound to a similar epitope on FGFR2 as R3Mab on FGFR3. The antibody was further engineered to decrease FGFR4-binding affinity while retaining affinity for FGFR3 and FGFR2. The resulting dual-specific antibodies blocked FGF binding to FGFR3 and FGFR2 and inhibited downstream signaling. Moreover, they displayed efficacy in mice against human tumor xenografts overexpressing FGFR3 or FGFR2. Thus, a monospecific antibody can be exquisitely tailored to confer or remove binding to closely related targets to expand and refine therapeutic potential.
Molten carbonate fuel cell cathode development (1984)

From the results obtained so far, Li/sub 2/MnO/sub 3/ and LiFeO/sub 2/ look promising as cathode materials for the MCFC. The materials have low solubility in the molten electrolyte and do not migrate under cell operating conditions. However, further studies of their resistivity is required before they can be fully assessed. Zinc oxide does not appear to be a good cathode material candidate due to its high solubility and its incorporation into the LiAlO/sub 2/ matrix, although the conductivity of doped ZnO is low enough for its application as a cathode.
Synthesis of Phenoxyacetic Acid Derivatives as Highly Potent Antagonists of Gastrin/Cholecystokinin-B Receptors. II. (1998)

A series of phenoxyacetanilide derivatives was synthesized and their antagonist activities for human gastrin/cholecystokinin (CCK)-B and CCK-A receptors were evaluated. Among the compounds synthesized, 2-[3-[3-[N-[2-(N-methyl-N-phenylcarbamoylmethoxy)phenyl]-N-(N-meth yl-N- phenylcarbamoylmethyl)carbamoylmethyl]-ureido]phenyl]acetic acid (20i, DA-3934) exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors. DA-3934 and its methyl ester derivative inhibited pentagastrin-induced gastric acid secretion in rats in a dose-dependent manner.
Abstract 694: Characterization of a novel monoclonal antibody to Glia maturation factor-beta showing significant clinical utility in the identification of breast carcinoma (2012)

Abstract Background: Glia maturation factor beta (GMF-beta) is a growth and differentiation factor of brain cells, stimulation of neural degeneration and inhibition of proliferation of tumor cells. It was recently found to involve in the progression of serous ovarian carcinoma. In the present study, we generated a novel antibody against human GMF-beta and investigated the potential of GMF-beta as a biomarker in breast cancer. Methods and findings: We generated a novel monoclonal antibody (mAb), AB-GMF-beta using hybridoma technology and native protein as an immunogen. This mAb is of IgG1 (kappa) type. It specifically recognized both native and denatured human GMF-beta protein and displayed high affinity as assessed by ELISA, immunohistochemistry assay, western blot and flow cytometry applications. Using this mAb in competitive ELISA, we showed for the first time that soluble GMF-beta level is significantly increased in metastatic breast cancer patients’ plasma which directly correlated with GMF-beta expression pattern in metastatic breast cancer tissues. Tissue expression of GMF-beta was determined by using immunohistochemical techniques. Seventy normal and 241 breast cancer tissues were included which consist of 194 ductal and 47 lobular carcinoma samples. Most of normal tissues showed negative or weak nuclear staining, while different levels of nuclear, and diffuse and weak cytoplasmic staining were observed in cancer sections. To evaluate the immunoreactivity of GMF-beta associated with tumor histological types, the staining intensity in nucleus were scored as 0, 1+, 2+ and 3+. Grade 0 and 1+ were defined as negative and 2+ and 3+ as positive. Forty four percent of ductal carcinomas showed strong staining whereas it is significantly increased to 72.3% in lobular tumors (p&lt;0.001). Conclusion: The novel AB-GMF-beta mAb showed high performance in blood and tissue assays. The circulating GMF-beta levels and expressions in breast tissues are significantly increased in breast cancer patients in comparison of normal controls. The increased tissue expressions in breast carcinoma associate with histological tumor types. Our data suggest the potential clinical use of GMF-beta as a biomarker for diagnosis and prognosis in blood and tissue as well as a therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 694. doi:1538-7445.AM2012-694
Discovery of 4-Aryl-4<i>H</i>-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High-Throughput Screening Assay. 1. Structure−Activity Relationships of the 4-Aryl Group (2004)

By applying a novel cell- and caspase-based HTS assay, 2-amino-3-cyano-7-(dimethylamino)-4-(3-methoxy-4,5-methylenedioxyphenyl)-4H-chromene (1a) has been identified as a potent apoptosis inducer. Compound 1a was found to induce nuclear fragmentation and PARP cleavage, as well as to arrest cells at the G(2)/M stage and to induce apoptosis as determined by the flow cytometry analysis assay in multiple human cell lines (e.g. Jurkat, T47D). Through structure-activity relationship (SAR) studies of the 4-aryl group, a 4- and 7-fold increase in potency was obtained from the screening hit 1a to the lead compounds 2-amino-4-(3-bromo-4,5-dimethoxyphenyl)-3-cyano-7-(dimethylamino)-4H-chromene (1c) and 2-amino-3-cyano-7-(dimethylamino)-4-(5-methyl-3-pyridyl)-4H-chromene (4e), with an EC(50) of 19 and 11 nM in the caspase activation assay in T47D breast cancer cells, respectively. The 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes also were found to be highly active in the growth inhibition MTT assay, with GI(50) values in the low nanomolar range for compound 1c. Significantly, compound 1c was found to have a GI(50) value of 2 nM in the paclitaxel resistant, p-glycoprotein overexpressed, MES-SA/DX5 tumor cells. Functionally, compound 1c was found to be a potent inhibitor of tubulin polymerization and to effectively inhibit the binding of colchicine to tubulin. These results confirm that the cell-based caspase activation assay is a powerful tool for the discovery of potent apoptosis inducers and suggest that the 4-aryl-4H-chromenes have the potential to be developed into future anticancer agents.
Cr/sup 2+/-doped II-VI crystals: new widely-tunable, room-temperature mid-IR lasers (2002)

We have demonstrated lasing in a new class of materials, Cr/sup 2+/-doped II-VI compounds. Their tuning ranges should eventually cover at least the 2100-3000 nm region, and efficient pumping with diode lasers is anticipated. This paper concentrates on absorption and emission spectroscopic properties and temperature-dependent emission lifetimes of ZnSe:Cr/sup 2+/.
Synthesis of oligomeric anilines (1997)

Parent aniline oligomers such as tetramer and “16-mer” have been synthesized by a general method. This method can be used to synthesize other oligomers by selecting appropriate ratios of reactants and appropriate oxidants. The oligomers were characterized by UV/Vis, IR, NMR, mass spectroscopy, GPC and elemental analysis. The conductivities of HCl doped oligomers were lower than that of polyaniline.
Microwave photonic injection locking frequency divider based on a tunable optoelectronic oscillator (2020)

We present a novel broadband divide-by-2 microwave photonic injection locking frequency divider (ILFD) based on a dual-loop optoelectronic oscillator (OEO). In the proposed scheme, a tunable microwave photonic filter is used to replace the traditional electrical filter, which makes sure a large tuning range of the ILFD. The microwave photonic ILFD whose center frequency tracks the tunable frequency of the free-running OEO, links up with every single locking range together. Thus the frequency range is only determined by the tunable OEO. In the experiment, a wide operating frequency range from 4.51 GHz to 34.88 GHz is realized. Furthermore, a divide-by-3 ILFD is experimentally demonstrated with the help of a frequency mixer.
Radiometric calibration from a single image (2004)

Photometric methods in computer vision require calibration of the camera's radiometric response, and previous works have addressed this problem using multiple registered images captured under different camera exposure settings. In many instances, such an image set is not available, so we propose a method that performs radiometric calibration from only a single image, based on measured RGB distributions at color edges. This technique automatically selects appropriate edge information for processing, and employs a Bayesian approach to compute the calibration. Extensive experimentation has shown that accurate calibration results can be obtained using only a single input image.
Clinical Cases where Lesion Therapy Was Chosen over Deep Brain Stimulation (2008)

Deep brain stimulation (DBS) surgery has become the gold standard for treatment of select refractory cases of Parkinson disease and essential tremor. Despite the usefulness of DBS surgery in many cases, there remain situations where lesion therapy (subthalamotomy, pallidotomy or thalamotomy) may provide a reasonable alternative to DBS. We reviewed the University of Florida Institutional Review Board-approved database for movement disorders surgery and identified 286 DBS leads placed in 189 patients as well as 4 additional patients who had lesion therapy. In these 4 cases we reviewed the clinical presentations that resulted in a multidisciplinary team opting for lesion therapy over DBS. Lesion therapy represents a viable alternative and has several important advantages, including a decreased need for access to specialists and clinical follow-up, improved affordability, and a lower infection risk.
Electroless Plating of Thin Gold Films Directly onto Silicon Nitride Thin Films and into Micropores (2014)

A method to directly electrolessly plate silicon-rich silicon nitride with thin gold films was developed and characterized. Films with thicknesses <100 nm were grown at 3 and 10 °C between 0.5 and 3 h, with mean grain sizes between ∼20 and 30 nm. The method is compatible with plating free-standing ultrathin silicon nitride membranes, and we successfully plated the interior walls of micropore arrays in 200 nm thick silicon nitride membranes. The method is thus amenable to coating planar, curved, and line-of-sight-obscured silicon nitride surfaces.