gebhart/patrepeval huggingface dataset:
Dihydroergotamine and Its Use in Migraine With Posterior Fossa Symptoms (2010)

Background.— Dihydroergotamine (DHE) has been used for decades to treat migraine, but is currently contraindicated in patients with hemiplegic migraine and basilar‐type migraine (BTM). Objective.— To assess the safety of DHE in patients with symptoms of BTM that do not meet criteria for BTM. Methods.— Retrospective analysis of patients admitted to an outpatient infusion room at a tertiary care center caring for patients with headache disorders. Incidence and types of adverse events as well as pain levels were reviewed and analyzed. Pain was assessed via the visual analog scale (VAS). Results.— Fifty consecutive patient records were reviewed. Mean age was 38.42. All patients met International Classification of Headache Disorders‐II (ICHD‐II) criteria for migraine and reported 1 posterior fossa symptom as defined by the ICHD‐II criteria for BTM. Patients did not necessarily have a posterior fossa symptom in the attack treated. Eighteen percent (9/50) patients had adverse events, and only 3 of these halted DHE infusion. No patients had neurologic or cardiologic events. The mean decrease in pain was 3 points on the VAS ( P < .0001). Sixty‐two percent of patients achieved complete relief of headache with co‐administration of DHE and other medications. Conclusion.— Dihydroergotamine showed no serious adverse events in patients with 1 posterior fossa symptom and migraine. Larger, adequately powered, controlled, prospective trials are indicated to assess safety of DHE in BTM.
Application of adaptive antenna technology to third generation radio architectures (2002)

Work at Bristol has considered the application of adaptive antenna technology to a mixed cell architecture employing DS-CDMA as the air interface. In the scenario considered, both the umbrella cells and the underlying micro cells operate within the same RF bandwidth in an attempt to support a seamless handover between different cell types. The paper presents an overview of the proposed mixed cell architecture employing adaptive antenna technology at the umbrella cell site, as well as the benefits that can be obtained from such a deployment. This is expressed in terms of the critical near-far problem and the system's capacity. Simulation and propagation results provide evidence for the claimed capabilities of the proposed system and estimates of the likely increased spectrum efficiency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Cultural Center (2016)

Abstract The Cultural Center, or Keimin Bunka Shidōsho in Japanese, was founded in Jakarta in 1943 to “accelerate the enlightenment and awakening of the people” and garner support for Japan’s war against the Allies through the arts. This central body oversaw and regulated performing arts to an unprecedented extent. Patriotic songs were composed and older songs rewritten to express wartime values. Models for writing sandiwara plays were developed by Armijn Pané and script competitions held. Itinerant troupes performed comical sketches or lelucon based on Japanese manzai. There were some dissident voices—including the avant-garde performance poet Chairil Anwar and the experimental theater group Maya—but all worked within the institutional confines of the Cultural Center and used mandated cultural symbols. While some see the Cultural Center as a repressive instrument, to others it was a microtopia that enabled cross-arts collaboration and a privileged space for rehearsing revolutionary ideals.
Chicken IgY: utilizing the evolutionary advantage (2004)

Laying hens are highly cost-effective producers of polyclonal antibodies in comparison with mammals as the antibodies can be purified from egg yolk. The antibodies are called IgY to differentiate them from mammalian IgG antibodies. Avian antibodies represent both a reduction and refinement in animal use. The cost for producing IgY is lower than for mammalian antibodies as chicken housing is cheap and the isolation/separation process is economical, high yielding, uncomplicated and fast.IgY antibodies do not cross-react with Fc receptors, mammalian immunoglobulins such as RF and HAMA or activate the complement system and thereby reducing the cause of false positive results in immunological assays. These properties have also made them attractive for peroral immunotherapy for a variety of gastrointestinal diseases, such as human rotaviruses, enterotoxigenic Escherichia coli and Salmonella spp. In the future the IgY technology offers great opportunities to be more widely used in immunotherapy, diagnostics and research.
Effects of Prostaglandin Inhibition on Vasopressin Levels in Women with Primary Dysmenorrhea (1982)

Arginine vasopressin (AVP) concentrations in plasma were studied in women with primary dysmenorrhea before and after treatment with naproxen, and in healthy control women on the first day of menstruation. In the treated group the AVP concentration was about 4 times higher than that in the controls, and the AVP level remained unchanged after almost complete pain relief had been obtained by treatment with the prostaglandin synthesis inhibitor. No significant differences were found between the 2 groups in plasma osmolality and sodium concentration on the first day of menstruation, or in the concentrations of progesterone and estradiol at this time or in the midluteal phase of the preceding menstrual cycle. These results indicate that increased secretion of AVP may play an etiologic role in dysmenorrhea, activating the uterus via a final step of prostaglandin synthesis an release.
Quinine as a potential tracer for medication adherence: A pharmacokinetic and pharmacodynamic assessment of quinine alone and in combination with oxycodone in humans (2015)

Effective strategies to monitor pharmacotherapy adherence are necessary, and sensitive biological markers are lacking. This study examined a subtherapeutic dose of quinine as a potential adherence tracer. Primary aims included examination of the plasma and urinary pharmacokinetic profile of once-daily quinine; secondary aims assessed pharmacokinetic/pharmacodynamic interactions with oxycodone (a CYP3A and CYP2D substrate). Healthy, nondependent opioid users (n = 9) were enrolled in this within-subject, double-blind, placebo-controlled inpatient study. Participants received the following oral doses: day 1, oxycodone (30 mg); days 2-4, quinine (80 mg); day 5, quinine and oxycodone (2 hours postquinine). Blood and 24-hour urine samples were collected throughout the study, and pharmacodynamic outcomes were assessed during experimental sessions (days 1, 4, 5). Quinine displayed a plasma Tmax ∼2 hours and t1/2 ∼10 hours. Oxycodone and noroxycodone parameters (Tmax , Cmax , t1/2 ) were similar with or without quinine present, although drug exposure (AUC) was slightly greater when combined with quinine. No pharmacodynamic interactions were detected, and doses were safely tolerated. During washout, quinine urinary concentrations steadily declined (elimination t1/2 ∼16 hours), with a 94% decrease observed 72 hours postdose. Overall, low-dose quinine appears to be a good candidate for a medication additive to monitor adherence for detection of missed medication.
THE USE OF OZONATION TO DEGRADE ORGANIC CONTAMINANTS IN WASTEWATERS (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE USE OF OZONATION TO DEGRADE ORGANIC CONTAMINANTS IN WASTEWATERSSUSAN J. MASTEN and SIMON H.R. DAVIESCite this: Environ. Sci. Technol. 1994, 28, 4, 180A–185APublication Date (Print):April 1, 1994Publication History Published online30 May 2012Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/es00053a718https://doi.org/10.1021/es00053a718research-articleACS PublicationsRequest reuse permissionsArticle Views1045Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells. (1996)

Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1; previously named HCP, PTP1C, SH-PTP1, and SHP) is a cytosolic protein tyrosine phosphatase that contains two SH2 domains. Recent data have demonstrated that the gene encoding SHP-1 is mutated in motheaten (mc) and viable motheaten (mc') mice resulting in autoimmune disease. More recently, SHP-1 has been shown to negatively regulate B cell antigen receptor (BCR)-initiated signaling. To elucidate potential mechanisms of SHP-1 action in BCR signal transduction, we studied proteins that interact with SHP-1 in B cells. Both anti-SHP-1 antibody and the two SH2 domains of SHP-1 expressed as glutathione S-transferase fusion proteins precipitated at least three phosphoproteins of approximately 75, 110, and 150 kD upon anti-immunoglobulin M stimulation of the WEHI-231 immature B cell line. Binding of SHP-1 to the 75- and 110-kD proteins appeared to be mediated mainly by the NH2-terminal SH2 domain of SHP-1, whereas both the NH2- and COOH-terminal SH2 domains are required for maximal binding to the 150-kD protein. Immunoprecipitation and Western blot analysis revealed that the SHP-1-associated 75-kD protein is the hematopoietic cell-specific, SH2-containing protein SLP-76. Further, this protein-protein association was constitutively observed and stable during the early phase of BCR signaling. However, significant tyrosine phosphorylation of SLP-76 as well as of SHP-1 was observed after BCR ligation. Constitutive association of SHP-1 with SLP-76 could also be detected in normal splenic B cells. Collectively, these results suggest possible mechanisms by which SHP-1 may modulate signals delivered by BCR engagement.
Stimulation Design and Evaluation of High Temperature SAGD Wells (2015)

This thesis presents an experimental approach to design, perform, and evaluate stimulation treatments for SAGD producers completed with slotted liners.\n\nHeavy oil production from a high temperature sandstone reservoir declined due to the blockage of slots in horizontal liners. Blocking materials were mainly presented by silicon-based scales, migrated fines, and numerous iron species. Previously, wells were mainly treated by HCl and a high pH chelating agent. These treatments did not improve the production significantly but corroded liners even more.\n\nThree liners were pulled out from the wells. Blocking and scaling materials were collected from the slots and walls of these liners for analysis. The experimental process included static acid solubility tests using 15 wt% HCl at room temperature, SEM, and XRD analysis. Also, it was proved that hydrochloric acid is not an optimal solution for blockage removal in these producers. Additionally, organic solvent preflush proved to be an effective potential improvement in the treatment design.\n\nOil sand samples were collected from the reservoir. The mineralogy of these samples was analyzed in detail. Organic matter was removed, and the rock samples were separated in sand, silt, and clay fractions. Presence of kaolinite, illite, muscovite, incomplete hydroxide interlayer smectite was proved by XRD, SEM, TEM, FTIR, and AAS. Also, interstratification of mica and kaolinite was observed. These results were used to make a decision concerning the choice of compatible treatment fluid.\n\nSeven stimulation treatments were conducted in five different wells using foamed chelating agent (GLDA). Flowback emulsion was separated and prepared for analysis which included ICP and GLDA titration. Additionally, the decomposition of GLDA at reservoir conditions was mimicked using aging cells. Decomposition products were identified using GC-MS and were found to be glutaric and aminodiacetic acids. Possible improvements in the treatment’s program and recommendations were formulated based on the obtained data. For example, the soaking time was reduced from 6 to 4 hours after the first treatment. Production data analysis proved the effectiveness of the treatment design.\n\nOverall, it was shown that only a systematic approach could be useful to design a successful treatment and achieve a positive impact.
A reaction cascade leading to 1,6-didehydro[10]annulene .fwdarw. 1,5-dehydronaphthalene cyclization initiated by thiol addition (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA reaction cascade leading to 1,6-didehydro[10]annulene .fwdarw. 1,5-dehydronaphthalene cyclization initiated by thiol additionAndrew G. Myers and Peter S. DragovichCite this: J. Am. Chem. Soc. 1993, 115, 15, 7021–7022Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/ja00068a089https://doi.org/10.1021/ja00068a089research-articleACS PublicationsRequest reuse permissionsArticle Views424Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Enhancing responses to cancer immunotherapy (2018)

The capacity of antigen presentation influences responses to checkpoint immunotherapy
Automatic defect classification using topography map from SEM photometric stereo (2004)

As the industry moves to smaller design rules, shrinking process windows and shorter product lifecycles, the need for enhanced yield management methodology is increasing. Defect classification is required for identification and isolation of yield loss sources. Practice demonstrates that an operator relies on 3D information heavily while classifying defects. Therefore, Defect Topographic Map (DTM) information can enhance Automatic Defect Classification (ADC) capabilities dramatically. In the present article, we describe the manner in which reliable and rapid SEM measurements of defect topography characteristics increase the classifier ability to achieve fast identification of the exact process step at which a given defect was introduced. Special multiple perspective SEM imaging allows efficient application of the photometric stereo methods. Physical properties of a defect can be derived from the 3D by using straightforward computer vision algorithms. We will show several examples, from both production fabs and R&D lines, of instances where the depth map is essential in correctly partitioning the defects, thus reducing time to source and overall fab expenses due to defect excursions.
Energy-aware data centre management (2011)

Cloud computing is one way in which communications within and between data centres can be optimised by using resources which are physically close to the client, are exposed to lower electricity costs, contribute a smaller carbon footprint or have residual resources sufficient to fulfil Quality of Service requirements. Optimisation of activity involving data centres is a next generation network management objective due to continued growth in the number of plants and volume of operations within, factors which contribute to environmental concerns associated with energy consumption and carbon emissions from data centre facilities when renewable energy resources are not used. In this paper, we present an algorithmic mechanism developed to automate selection of a data centre in response to application requests, the Data Centre (DC) Energy-Efficient Context-Aware Broker (e-CAB). Through integration of the DCe-CAB in a case study scenario, operational improvement through reduction of carbon emission and balancing of other performance-related attributes including delay and financial cost is achieved, validating the DCe-CAB's positive impact.
1,4-Dihydro-4-oxopyridinecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent (1984)

The title compounds having nitro, amino, cyano, chloro, or fluoro as the C-6 substituent were prepared. Introduction of the chloro and cyano groups at C-6 was accomplished by the Sandmeyer reaction of 6-amino-1,8-naphthyridine derivatives 9 via their 6-diazonium salts. The reaction was extended to the synthesis of the 6-fluoro analogues, involving the Balz-Schiemann reaction of the diazonium tetrafluoroborate. Furthermore, a series of the 1-ethyl, 1-vinyl, 1-(2-fluoroethyl), and 1-(difluoromethyl) analogues of 7-substituted 6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids was prepared. 1-Pyrrolidinyl and, particularly, N-substituted or unsubstituted 1-piperazinyl groups were introduced as the C-7 variants. As a result of this study, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine-3-carboxylic acid (named enoxacin, originally AT-2266) was found to show the most broad and potent in vitro antibacterial activity, an excellent in vivo efficacy on systemic infections, and a weak acute toxicity. Structure-activity relationships of compounds with variations of substituents at C-1, C-6, and C-7 are also discussed.
Development and Validation of a High-Density Fluorescence Polarization-Based Assay for the Trypanosoma RNA Triphosphatase TbCet1 (2009)

RNA triphosphatases are attractive and mostly unexplored therapeutic targets for the development of broad spectrum antiprotozoal, antiviral and antifungal agents. The use of malachite green as a readout for phosphatases is well characterized and widely employed. However, the reaction depends on high quantities of inorganic phosphate to be generated, which makes this assay not easily amenable to screening in 1536-well format. The overly long reading times required also prohibit its use to screen large chemical libraries. To overcome these limitations, we sought to develop a fluorescence polarization (FP) -based assay for triphosphatases, compatible with miniaturization and fast readouts. For this purpose, we took advantage of the nucleoside triphosphatase activity of this class of enzyme to successfully adapt the Transcreener ADP assay based on the detection of generated ADP by immunocompetition fluorescence polarization to the RNA triphosphatase TbCet1 in 1536-well format. We also tested the performance of this newly developed assay in a pilot screen of 3,000 compounds and we confirmed the activity of the obtained hits. We present and discuss our findings and their importance for the discovery of novel drugs by high throughput screening.
General Aspects of the Glycosidic Bond Formation (2008)

This chapter contains sections titled: Introduction Major Types of O-Glycosidic Linkages Historical Development: Classes of Glycosyl Donors General Reaction Mechanism Anomeric Effects Stereoselectivity of Glycosylation Structure of the Glycosyl Donor Protecting Groups Leaving Group Structure of the Glycosyl Acceptor Position of the Hydroxyl Protecting Groups Reaction Conditions Solvent Effect Promoter (Catalyst), Additions Temperature and Pressure Other Factors Special Cases of Glycosylation Aminosugars Sialosides Synthesis of 2-Deoxyglycosides Synthesis of β-Mannosides Synthesis of Furanosides Glycosylation and Oligosaccharide Sequencing Leaving-Group-Based Strategies Two-Step Activation and Preactivation Strategies Protecting-Group-Based Strategies Conclusions and Outlook References
원보 ; 상륙성분에 관한 연구 ( II ) 자리공 , 양자리공 , 섬자리공의 성분비교 (1976)

Steroid and terpenoid constituents of 3 species of genus Phytolacca have been examined by TLC. All contained α-spinasterol, its glucoside and acylated glucoside, jaligonic acid and its methylester, esculentic acid and its methylester, and 10 phytolaccosides. Jaligonic acid was the major free triterpenoid and phytolaccoside E was the major saponin in all plants. Bayogenin, oleanolic acid, spergulagenic acid, acinosolic acid, hederogenin, and their derivatives contained in other Phytolacca spp. were not found in these plants.
Plane-wave illumination of concentric-ring frequency-selective surfaces (1985)

In the paper we present the results of a modal analysis of the current distribution around the circumference of thin concentric rings arranged on both square and equilateral triangular lattices. The particular case of plane-wave illumination at 45° incidence is considered owing to its relevance to oblique-incidence diplexer systems. Measured and predicted transmission curves, together with computer curves illustrating the frequency dependence of various current-mode amplitudes, are plotted for selected concentric-ring structures, each with the same mean radius for the outer ring, but with different inner-ring radii. The results relate individual current modes to features in the observed transmission curves. They confirm that the copolar transmission and lower reflection bands can be modelled with only one current mode in each ring. Crosspolar effects are discussed for incidence on the square lattice in the planes ϕ = 0, 45° and 90°, where they are shown to be small for pure TE and TM.
Dynamic foams in topical drug delivery (2010)

Recent literature suggests that when foams are properly engineered using the advances of in situ analysis techniques, the enhancement of topical drug delivery via engineering this type of vehicle can be achieved.