gebhart/patrepeval huggingface dataset:
Reverse-Body Biasing for Radiation-Hard by Design Logic Gates (2007)

Different radiation hardening by design techniques for mitigating total ionizing dose (TID) effects in NMOS transistors are presented. NMOS annular layout transistors are compared to two-edge and hardened by reverse-body bias (RBB) with respect to CMOS gate area, delay, active and leakage power, and TID hardness. Accelerated testing using Co-60 irradiation of test structures on a 130 nm bulk CMOS process shows that RBB provides smaller devices and allows less chip-level leakage at 1 Mrad(Si) than a design hardened using annular gates has pre-irradiation. Simulations of fanout-of-four (FO4) two-input NAND gates show that RBB provides an energy-delay product (EDP) comparable to conventional two-edge gates. Different annular topologies have EDP 35% to over 350% greater
C1q/TNF-related Protein-3 (CTRP3), a Novel Adipokine That Regulates Hepatic Glucose Output (2010)

Adipose tissue-derived adipokines play important roles in controlling systemic insulin sensitivity and energy balance. Our recent efforts to identify novel metabolic mediators produced by adipose tissue have led to the discovery of a highly conserved family of secreted proteins, designated as C1q/TNF-related proteins 1-10 (CTRP1 to -10). However, physiological functions regulated by CTRPs are largely unknown. Here we provide the first in vivo functional characterization of CTRP3. We show that circulating levels of CTRP3 are inversely correlated with leptin levels; CTRP3 increases with fasting, decreases in diet-induced obese mice with high leptin levels, and increases in leptin-deficient ob/ob mice. A modest 3-fold elevation of plasma CTRP3 levels by recombinant protein administration is sufficient to lower glucose levels in normal and insulin-resistant ob/ob mice, without altering insulin or adiponectin levels. The glucose-lowering effect in mice is linked to activation of the Akt signaling pathway in liver and a marked suppression of hepatic gluconeogenic gene expression. Consistent with its effects in mice, CTRP3 acts directly and independently of insulin to regulate gluconeogenesis in cultured hepatocytes. In humans, alternative splicing generates two circulating CTRP3 isoforms differing in size and glycosylation pattern. The two human proteins form hetero-oligomers, an association that does not require interdisulfide bond formation and appears to protect the longer isoform from proteolytic cleavage. Recombinant human CTRP3 also reduces glucose output in hepatocytes by suppressing gluconeogenic enzyme expression. This study provides the first functional evidence linking CTRP3 to hepatic glucose metabolism and establishes CTRP3 as a novel adipokine.
Localization of lipoprotein-delivered benzoporphyrin derivative in the rabbit eye (1997)

BPD-MA with LDL rapidly accumulates in the choroid, RPE, and photoreceptors after intravenous injection. Future studies of PDT with BPD-MA for the treatment of fundus disorders may need to address the relationship between dye localization and photodynamically-mediated injury.
Real time recursive parameter estimation in energy management systems (1996)

A new method of recursive parameter estimation using a Kalman filter is presented. The method is capable of estimating impedance parameters of network branches in both online and offline modes. It provides accurate estimation of branch parameters in the presence of noise in measurements and has the ability to identify and reject gross measurement errors. The method can track impedance parameters as they fluctuate due to changes in load and ambient conditions. Test results on a 100-bus network as well as results of method's implementation in a real life EMS are reported in the paper.
Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis (2015)

This study identifies a set of miRNAs in whole blood, which may have the potential to discriminate NMOSD from CIS/RRMS and healthy controls. In contrast, miRNA profiles in serum do not appear to be promising diagnostic biomarkers for NMOSD. Enrichment of altered miRNAs in CD15(+) neutrophils and eosinophils, which were previously implicated in the pathophysiology of NMOSD, suggests that miRNAs could be involved in the regulation of these cells in NMOSD.
Duchenne and Becker Muscular Dystrophy: From Gene Diagnosis to Molecular Therapy (2002)

Duchenne and Becker muscular dystrophy (DMD/BMD) are X-linked muscular dystrophies. The isolation of the defective gene in DMD/BMD has led to a better understanding of the disease process and has promoted studies regarding the application of molecular therapy. The purpose of this review is to present the progress made in this area of research with particular reference to dystrophin Kobe. Based on the results from the molecular analysis of dystrophin Kobe, we propose a novel molecular therapeutic method for DMD in which antisense oligonucleotides transform DMD into a milder phenotype by inducing exon skipping. In addition, current proposals for the molecular therapy of DMD are discussed.
Learned D-AMP: Principled Neural Network based Compressive Image Recovery (2017)

Compressive image recovery is a challenging problem that requires fast and accurate algorithms. Recently, neural networks have been applied to this problem with promising results. By exploiting massively parallel GPU processing architectures and oodles of training data, they can run orders of magnitude faster than existing techniques. However, these methods are largely unprincipled black boxes that are difficult to train and often-times specific to a single measurement matrix. It was recently demonstrated that iterative sparse-signal-recovery algorithms can be "unrolled" to form interpretable deep networks. Taking inspiration from this work, we develop a novel neural network architecture that mimics the behavior of the denoising-based approximate message passing (D-AMP) algorithm. We call this new network Learned D-AMP (LDAMP). The LDAMP network is easy to train, can be applied to a variety of different measurement matrices, and comes with a state-evolution heuristic that accurately predicts its performance. Most importantly, it outperforms the state-of-the-art BM3D-AMP and NLR-CS algorithms in terms of both accuracy and run time. At high resolutions, and when used with sensing matrices that have fast implementations, LDAMP runs over $50\times$ faster than BM3D-AMP and hundreds of times faster than NLR-CS.
Subtopic-driven Multi-Document Summarization (2019)

Xin Zheng, Aixin Sun, Jing Li, Karthik Muthuswamy. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing (EMNLP-IJCNLP). 2019.
Portable dynamic light scattering instrument and method for the measurement of blood platelet suspensions (2006)

No routine test exists to determine the quality of blood platelet transfusions although every year millions of patients require platelet transfusions to survive cancer chemotherapy, surgery or trauma. A new, portable dynamic light scattering instrument is described that is suitable for the measurement of turbid solutions of large particles under temperature-controlled conditions. The challenges of small sample size, short light path through the sample and accurate temperature control have been solved with a specially designed temperature-controlled sample holder for small diameter, disposable capillaries. Efficient heating and cooling is achieved with Peltier elements in direct contact with the sample capillary. Focusing optical fibres are used for light delivery and collection of scattered light. The practical use of this new technique was shown by the reproducible measurement of latex microspheres and the temperature-induced morphological changes of human blood platelets. The measured parameters for platelet transfusions are platelet size, number of platelet-derived microparticles and the response of platelets to temperature changes. This three-dimensional analysis provides a high degree of confidence for the determination of platelet quality. The experimental data are compared to a matrix and facilitate automated, unbiased quality testing.
High power laser applications in Nippon Steel Corporation (2003)

The full-scale use of lasers in the steel industry began 25 years ago with their applications as controllable light sources. The laser systems contribute to increase efficiency and quality of the steel making processes, and also save energy of resources and labor. Laser applications in the steel making process generally require high input energy, however, it is essential to consider the interaction between the laser beam and materials. In particular, the reflectivity of the laser beam on the surface of material and the quantity of the laser-induced plasma are critical parameters for high efficient processes. We newly developed methods and systems of high power 45 kW CO<sub>2</sub> laser welding of hot steel specimens with their applications as welding characteristics of hot steel specimens that temperature is about 1000 degree C, have been examined. Using laser induced plasma as a secondary heat source, the penetration depth improves about 30% compared to that at room temperature. The bead width is also enlarged by 10%. The maximum depth is 38 mm at 1m/min welding velocity at 40 kW. A beam weaving method is adopted for further enlargement of bead width without degrading fusion efficiency. It is also effective for suppressing the bead depth deviation. Additionally, several new applications, for example, new type all-laser-welded honeycomb panels for high- speed civil transport, will be talked.
Reactive‐ion etch resistant polysulfones for microlithography (1992)

Abstract The various chemical approaches aimed at improving the reactive‐ion etch resistance of poly(olefin sulfone)s are described. Resist systems based on incorporation of RIE‐resistant moieties via random copolymerization, blending and block copolymer formation are described and lithographic properties noted.
Network-Coded Multiple Access (2013)

This paper proposes and experimentally demonstrates a first wireless local area network (WLAN) system that jointly exploits physical-layer network coding (PNC) and multiuser decoding (MUD) to boost system throughput. We refer to this multiple access mode as Network-Coded Multiple Access (NCMA). Prior studies on PNC mostly focused on relay networks. NCMA is the first realized multiple access scheme that establishes the usefulness of PNC in a non-relay setting. NCMA allows multiple nodes to transmit simultaneously to the access point (AP) to boost throughput. In the non-relay setting, when two nodes A and B transmit to the AP simultaneously, the AP aims to obtain both packet A and packet B rather than their network-coded packet. An interesting question is whether network coding, specifically PNC which extracts packet (A XOR B), can still be useful in such a setting. We provide an affirmative answer to this question with a novel two-layer decoding approach amenable to real-time implementation. Our USRP prototype indicates that NCMA can boost throughput by 100% in the medium-high SNR regime (>=10dB). We believe further throughput enhancement is possible by allowing more than two users to transmit together.
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin (1997)

Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine repeat in the HD protein huntingtin. Huntingtin's localization within the cell includes an association with cytoskeletal elements and vesicles. We previously identified a protein (HAP1) which binds to huntingtin in a glutamine repeat length-dependent manner. We now report that HAP1 interacts with cytoskeletal proteins, namely the p150 Glued subunit of dynactin and the pericentriolar protein PCM-1. Structural predictions indicate that both HAP1 and the interacting proteins have a high probability of forming coiled coils. We examined the interaction of HAP1 with p150 Glued . Binding of HAP1 to p150 Glued (amino acids 879-1150) was confirmed in vitro by binding of p150 Glued to a HAP1-GST fusion protein immobilized on glutathione-Sepharose beads. Also, HAP1 co-immunoprecipitated with p150 Glued from brain extracts, indicating that the interaction occurs in vivo . Like HAP1, p150 Glued is highly expressed in neurons in brain and both proteins are enriched in a nerve terminal vesicle-rich fraction. Double label immunofluorescence experiments in NGF-treated PC12 cells using confocal microscopy revealed that HAP1 and p150 Glued partially co-localize. These results suggest that HAP1 might function as an adaptor protein using coiled coils to mediate interactions among cytoskeletal, vesicular and motor proteins. Thus, HAP1 and huntingtin may play a role in vesicle trafficking within the cell and disruption of this function could contribute to the neuronal dysfunction and death seen in HD.
Invyswell (2014)

The Intel Haswell processor includes restricted transactional memory (RTM), which is the first commodity-based hardware transactional memory (HTM) to become publicly available. However, like other real HTMs, such as IBM's Blue Gene/Q, Haswell's RTM is best-effort, meaning it provides no transactional forward progress guarantees. Because of this, a software fallback system must be used in conjunction with Haswell's RTM to ensure transactional programs execute to completion. To complicate matters, Haswell does not provide escape actions. Without escape actions, non-transactional instructions cannot be executed within the context of a hardware transaction, thereby restricting the ways in which a software fallback can interact with the HTM. As such, the challenge of creating a scalable hybrid TM (HyTM) that uses Haswell's RTM and a software TM (STM) fallback is exacerbated.
Substantially single phase superconducting oxide ceramics having a tc above 85 k and a method of making the ceramic (1988)

A substantially single phase superconducting composition is formed from a of 1:2:3 molar ratio of fine powders of a superconducting rare earth oxide, CuO, and BaCO/sub 3/. The mixed powders and shaped articles formed from the mixed powders are calcined, sintered, and cooled in an oxygen containing atmosphere. The cooling step is done slowly to improve the superconducting properties. The article formed is a substantially single-phase superconducting composition.
Real-Time Design of Improved Powder Pressing Dies Using Finite Element Method Modeling (2000)

A predictive model for powder compaction has been developed that incorporates unprecedented flexibility to design powder press tooling and reliable powder pressing processes.Sandia's finite element (FE) toolkit comprises the heart of the modeling software, and a unique concept was developed to design a variable dimension and parameter template to easily build/design dies/components on a computer.The result is user-friendly software to simulate powder compaction that can run on a desktop or laptop personal computer by a non-expert with minimal training.The software has been tested and validated by direct comparison to experimentally measured density gradients in green ceramic powder compacts.The software has been used successfully to enhance our fundamental understanding of ceramic powder pressing, and has provided guidance to achieve better process reproducibility, reliability, and control.This technology will contribute significantly to press powder manufacturing by: 1) reducing manufacturing costs, cycle time, and waste; 2) enabling more cost effective manufacturing of specialty components and small lot sizes; 3) reducing tooling and component design, development, and prototype time; and 4) maximizing design and manufacturing flexibility/agility.
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution (2011)

A high-resolution structure of a ligand-bound, soluble form of human monoglyceride lipase (MGL) is presented. The structure highlights a novel conformation of the regulatory lid-domain present in the lipase family as well as the binding mode of a pharmaceutically relevant reversible inhibitor. Analysis of the structure lacking the inhibitor indicates that the closed conformation can accommodate the native substrate 2-arachidonoyl glycerol. A model is proposed in which MGL undergoes conformational and electrostatic changes during the catalytic cycle ultimately resulting in its dissociation from the membrane upon completion of the cycle. In addition, the study outlines a successful approach to transform membrane associated proteins, which tend to aggregate upon purification, into a monomeric and soluble form.
Inhibition of Lactate Production in Rat Brain Extracts and Synaptosomes by 3‐[4‐(Reduced 3‐Pyridine Aldehyde‐Adenine Dinucleotide)]‐Pyruvate (1987)

In basic solutions, pyruvate enolizes and reacts (through its 3-carbon) with the 4-carbon of the nicotinamide ring of NAD+, yielding an NAD-pyruvate adduct in which the nicotinamide ring is in the reduced form. This adduct is a strong inhibitor of lactate dehydrogenase, presumably because it binds simultaneously to the NADH and pyruvate sites. The potency of the inhibition, however, is muted by the adduct's tendency to cyclize to a lactam. We prepared solutions of the pyruvate adduct of NAD+ and of NAD+ analogues in which the -C(O)NH2 of NAD+ was replaced with -C(S)NH2, -C(O)CH3, and -C(O)H. Of the four, only the last analogue, 3-[4-(reduced 3-pyridine aldehyde-adenine dinucleotide)]-pyruvate (RAP) cannot cyclize and it was found to be the most potent inhibitor of beef heart and rat brain lactate dehydrogenases. The inhibitor binds very tightly to the NADH site (Ki approximately 1 nM for the A form). Even at high concentrations (20 microM), RAP had little or no effect on rat brain glyceraldehyde-3-phosphate, pyruvate, alpha-ketoglutarate, isocitrate, soluble and mitochondrial malate, and glutamate dehydrogenases. The glycolytic enzymes, hexokinase and phosphofructokinase, were similarly unaffected. RAP strongly inhibited lactate production from glucose in rat brain extracts but was less effective in inhibiting lactate production from glucose in synaptosomes.
Anti-carbamylated protein antibodies: are they useful for the diagnosis of rheumatoid arthritis? (2021)

For RA classification, anti-CarP+ was less sensitive than ACPA, but more specific than RF. Anti-CarP+ may prove useful, classifying early arthritis patients, notably ACPA- patients.
SHORT COMMUNICATION:Response of nicotianamine synthase activity to Fe-deficiency in tobacco plants as compared with barley (1995)

In vitro nicotianamine synthase activity was measured in tobacco under Fe-deficient or Fe-sufficient conditions. Its activity was not induced by Fe-deficiency, in contrast to barley roots, implying that the molecular biological regulation of nicotianamine synthase in response to Fe-deficiency may be different between tobacco and barley.
Detection of Infectious <i>Cryptosporidium parvum</i> Oocysts in Surface and Filter Backwash Water Samples by Immunomagnetic Separation and Integrated Cell Culture-PCR (1999)

A new strategy for the detection of infectious Cryptosporidium parvum oocysts in water samples, which combines immunomagnetic separation (IMS) for recovery of oocysts with in vitro cell culturing and PCR (CC-PCR), was field tested with a total of 122 raw source water samples and 121 filter backwash water grab samples obtained from 25 sites in the United States. In addition, samples were processed by Percoll-sucrose flotation and oocysts were detected by an immunofluorescence assay (IFA) as a baseline method. Samples of different water quality were seeded with viable C. parvum to evaluate oocyst recovery efficiencies and the performance of the CC-PCR protocol. Mean method oocyst recoveries, including concentration of seeded 10-liter samples, from raw water were 26.1% for IMS and 16.6% for flotation, while recoveries from seeded filter backwash water were 9.1 and 5.8%, respectively. There was full agreement between IFA oocyst counts of IMS-purified seeded samples and CC-PCR results. In natural samples, CC-PCR detected infectious C. parvum in 4.9% (6) of the raw water samples and 7.4% (9) of the filter backwash water samples, while IFA detected oocysts in 13.1% (16) of the raw water samples and 5.8% (7) of the filter backwash water samples. All CC-PCR products were confirmed by cloning and DNA sequence analysis and were greater than 98% homologous to the C. parvum KSU-1 hsp70 gene product. DNA sequence analysis also revealed reproducible nucleotide substitutions among the hsp70 fragments, suggesting that several different strains of infectious C. parvum were detected.
ChemInform Abstract: Photosensitive Characteristics of Dopant‐Free, Ultraviolet‐Sensitive Calcium Aluminate Glasses. (1988)

Abstract Undoped CaO‐Al 2 O 3 glasses show a high sensitivity to UV irradiation, which strongly depends on the wavelength of the UV radiation.
Proposal for a scalable charging-energy-protected topological qubit in a\n quantum spin Hall system (2020)

The quantum spin Hall edge is predicted to reliably produce Majorana zero\nmodes on the border between magnetic insulator- and superconductor-proximitized\nregions of the edge. The direction of magnetization determines the size of the\ninduced magnetic gap and can control the resulting tunnel barrier. Here we\npropose a way to avoid magnetic manipulations of the material and use\nelectric-only local control of the barrier. We follow with a design of a\ncharging-energy-protected qubit and a layout of a quantum computer based on the\nquantum spin Hall effect. We estimate relevant scales and show that they allow\nfor testing of these ideas in the near future.\n
Silicon crystal growing by oscillating crucible technique (1983)

A process for growing silicon crystals from a molten melt comprising oscillating the container during crystal growth is disclosed.