gebhart/patrepeval huggingface dataset:
SPX: Preserving End-to-End Security for Edge Computing (2018)

Beyond point solutions, the vision of edge computing is to enable web services to deploy their edge functions in a multi-tenant infrastructure present at the edge of mobile networks. However, edge functions can be rendered useless because of one critical issue: Web services are delivered over end-to-end encrypted connections, so edge functions cannot operate on encrypted traffic without compromising security or degrading performance. Any solution to this problem must interoperate with existing protocols like TLS, as well as with new emerging security protocols for client and IoT devices. The edge functions must remain invisible to client-side endpoints but may require explicit control from their service-side web services. Finally, a solution must operate within overhead margins which do not obviate the benefits of the edge. To address this problem, this paper presents SPX - a solution for edge-ready and end-to-end secure protocol extensions, which can efficiently maintain end-to-edge-to-end ($E^3$) security semantics. Using our SPX prototype, we allow edge functions to operate on encrypted traffic, while ensuring that security semantics of secure protocols still hold. SPX uses Intel SGX to bind the communication channel with remote attestation and to provide a solution that not only defends against potential attacks but also results in low performance overheads, and neither mandates any changes on the end-user side nor breaks interoperability with existing protocols.
Accelerating multi-user large vocabulary continuous speech recognition on heterogeneous CPU-GPU platforms (2016)

In our previous work, we developed a GPU-accelerated speech recognition engine optimized for faster than real time speech recognition on a heterogeneous CPU-GPU architecture. In this work, we focused on developing a scalable server-client architecture specifically optimized to simultaneously decode multiple users in real-time. In order to efficiently support real-time speech recognition for multiple users, a "producer/consumer" design pattern was applied to decouple speech processes that run at different rates in order to handle multiple processes at the same time. Furthermore, we divided the speech recognition process into multiple consumers in order to maximize hardware utilization. As a result, our platform architecture was able to process more than 45 real-time audio streams with an average latency of less than 0.3 seconds using one-million-word vocabulary language models.
Micromachined piezoelectrically actuated flextensional transducers for high resolution printing and imaging (2002)

In this paper, we present a technique for the deposition of inks, toners, organic polymers, fuels, small solid particles, biological and chemical fluids, using a fluid ejector. The ejector design is based on a flextensional transducer that excites the axisymmetric resonant modes of a clamped circular plate. It is constructed by depositing a thin piezoelectric annular plate onto a thin, edge clamped, circular plate. Liquids or solid-particles are placed behind one face of the plate which has a small orifice at its center. By applying an ac signal across the piezoelectric element, continuous or drop-on-demand ejection of fluids has been achieved. The ejected drop size ranges in diameter from 4 /spl mu/m at 3.5 MHz to 150 /spl mu/m at 7 kHz, the corresponding ejected drop volume ranges from 34 fl to 1.5 nl, and the corresponding flow rate ranges from 117 nl/s to 10 /spl mu/l/s. The unique features of the device are that the fluid is not pressurized, the fluid container is chemically or biologically compatible with most fluids, and the vibrating plate contains the orifice as the ejection source. The device is manufactured by silicon surface micromachining and implemented in the form of two-dimensional arrays. Individual elements are made of thin silicon nitride membranes covered by a coating of piezoelectric zinc oxide. Classical thin plate theory and Mindlin plate theory are applied to derive two-dimensional plate equations for the transducer, and to calculate the coupled electromechanical field variables such as mechanical displacement and electrical input impedance. In these methods, the variations across the thickness direction vanish by using the bending moments per unit length or stress resultants. Thus, two-dimensional plate equations for a step-wise laminated circular plate are obtained as well as two different solutions to the corresponding systems. An equivalent circuit of the transducer is also obtained from these solutions.
Recycling Waste Polyester via Modification with a Renewable Fatty Acid for Enhanced Processability (2018)

Polyethylene terephthalate (PET) waste often contains a large amount of thermally unstable contaminants and additives that negatively impacts processing. A reduced processing temperature is desired. In this work, we report using a renewably sourced tall oil fatty acid (TOFA) as a modifier for recycled PET. To that end, PET was compounded with TOFA at different concentrations and extruded at 240 °C. Phase transition behaviors characterized by thermal and dynamic mechanical analyses exhibit shifts in the melting and recrystallization temperatures of PET to lower temperatures and depression of glass transition temperature from 91 to 65 °C. Addition of TOFA also creates crystal-phase imperfection that slows recrystallization, an important processing parameter. Changes in the morphology of plasticized PET reduces and stabilizes the melt viscosity at 240 and 250 °C. Melt-spun, undrawn continuous filaments of diameter 36-46 μm made from these low-melting PET exhibit 29-38 MPa tensile strength, 2.7-2.8 GPa tensile modulus, and 20-36% elongation. These results suggest a potential path for reusing waste PET as high-performance polymeric fibers.
Multichannel optical correlator for radar signal processing (1978)

A multichannel coherent optical processor for radar signals is described in which pulse compression is achieved by matched spatial filtering. The optical system can be used for phased array, linear frequency modulated pulse burst, or other radar systems. However, only its application to linear phased array signal processing is discussed in depth. From the output optical pattern, one can obtain data on the target's fine range and azimuth (for a phased array) or fine range and Doppler (for a pulse burst radar) etc.
The Synthesis and Biological Activity of 1-Alkyl-4-(3-azacyclobenzoyl)-5-hydroxypyrazole Herbicides (2003)

The benzoylpyrazoles belong to a class of herbicides that inhibit the enzyme 4-hydroxy-phenylpyruvate dioxygenase (HPPD). This mode of action is characterized by bleaching due to the disruption of plastoquinone and ?-tocopherol biosynthesis. Early studies indicated that the C(3) position of benzoylpyrazoles can accommodate a wide range of functionality. This paper describes synthetic efforts to improve cool season grass weed activity and wheat selectivity by incorporating cyclic moieties attached through nitrogen at this position. The aza substituents were generally installed by nucleophilic aromatic substitution, however, an efficient four-step method was developed for constructing substituted morpholino moieties directly on pre-formed benzoylpyrazoles. The structure–activity relationships revealed that certain piperidino moieties provided good activity on wild oat, while exhibiting selectivity toward wheat. They also showed that excellent levels of activity on wild oat and blackgrass can be achieved with morpholino substituents.
Quantitative analysis of the central-chest lymph nodes based on 3D MDCT image data (2009)

Lung cancer is the leading cause of cancer death in the United States. In lung-cancer staging, central-chest lymph nodes and associated nodal stations, as observed in three-dimensional (3D) multidetector CT (MDCT) scans, play a vital role. However, little work has been done in relation to lymph nodes, based on MDCT data, due to the complicated phenomena that give rise to them. Using our custom computer-based system for 3D MDCT-based pulmonary lymph-node analysis, we conduct a detailed study of lymph nodes as depicted in 3D MDCT scans. In this work, the Mountain lymph-node stations are automatically defined by the system. These defined stations, in conjunction with our system's image processing and visualization tools, facilitate lymph-node detection, classification, and segmentation. An expert pulmonologist, chest radiologist, and trained technician verified the accuracy of the automatically defined stations and indicated observable lymph nodes. Next, using semi-automatic tools in our system, we defined all indicated nodes. Finally, we performed a global quantitative analysis of the characteristics of the observed nodes and stations. This study drew upon a database of 32 human MDCT chest scans. 320 Mountain-based stations (10 per scan) and 852 pulmonary lymph nodes were defined overall from this database. Based on the numerical results, over 90% of the automatically defined stations were deemed accurate. This paper also presents a detailed summary of central-chest lymph-node characteristics for the first time.
Anti-RNA polymerase I antibodies in sera of MRL lpr/lpr and MRL +/+ autoimmune mice. Correlation of antibody production with delayed onset of lupus-like disease in MRL +/+ mice. (1985)

Sera from individual MRL/lpr and MRL/++ mice, which develop an autoimmune disease similar to human systemic lupus erythematosus (SLE), were screened over a period of approximately 30 wk for the presence of anti-RNA polymerase I and anti-ssDNA antibodies. Even though onset of the disease is delayed in MRL/++ as compared to MRL/lpr mice, anti-ssDNA antibodies were present in comparable concentrations in the sera of all mice by the age of 6 wk. As observed in sera of human SLE patients, anti-RNA polymerase I antibodies were detected in the sera of all MRL mice. However, unlike the anti-ssDNA antibodies, anti-RNA polymerase I antibodies were detected much later in MRL/++ mice (mean age, 22.8 wk) as compared to MRL/lpr mice (mean age, 9.6 wk). The presence of anti-RNA polymerase I antibodies in sera of MRL mice was thus a much better indicator of disease status than the presence of anti-ssDNA antibodies. The appearance and increase in anti-RNA polymerase I antibodies in the sera of MRL/++ mice correlated (R2 = 0.964) with a precipitous decrease in anti-ssDNA antibodies, starting at about 20 wk of age. These results suggest a possible relationship between the RNA polymerase I and DNA autoimmune reactions.
A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B (2019)

The DNA cytosine deaminase APOBEC3B (A3B) is normally an antiviral factor in the innate immune response. However, A3B has been implicated in cancer mutagenesis, particularly in solid tumors of the bladder, breast, cervix, head/neck, and lung. Here, we report data on the generation and characterization of a rabbit monoclonal antibody (mAb) for human A3B. One mAb, 5210-87-13, demonstrates utility in multiple applications, including ELISA, immunoblot, immunofluorescence microscopy, and immunohistochemistry. In head-to-head tests with commercial reagents, 5210-87-13 was the only rabbit monoclonal suitable for detecting native A3B and for immunohistochemical quantification of A3B in tumor tissues. This novel mAb has the potential to enable a wide range of fundamental and clinical studies on A3B in human biology and disease.
Widely Applicable Synthesis of Enantiomerically Pure Tertiary Alkyl‐Containing 1‐Alkanols by Zirconium‐Catalyzed Asymmetric Carboalumination of Alkenes and Palladium‐ or Copper‐Catalyzed Cross‐Coupling (2013)

A highly enantioselective and widely applicable method for the synthesis of various chiral 2-alkyl-1-alkanols, especially those of feeble chirality, has been developed. It consists of zirconium-catalyzed asymmetric carboalumination of alkenes (ZACA), lipase-catalyzed acetylation, and palladium- or copper-catalyzed cross-coupling. By virtue of the high selectivity factor (E) associated with iodine, either (S)- or (R)-enantiomer of 3-iodo-2-alkyl-1-alkanols (1), prepared by ZACA reaction of allyl alcohol, can be readily purified to the level of ≥99% ee by lipase-catalyzed acetylation. A variety of chiral tertiary alkyl-containing alcohols, including those that have been otherwise difficult to prepare, can now be synthesized in high enantiomeric purity by Pd- or Cu-catalyzed cross-coupling of (S)-1 or (R)-2 for introduction of various primary, secondary, and tertiary carbon groups with retention of all carbon skeletal features. These chiral tertiary alkyl-containing alcohols can be further converted into the corresponding acids with full retention of the stereochemistry. The synthetic utility of this method has been demonstrated in the highly enantioselective (≥99% ee) and efficient syntheses of (R)-2-methyl-1-butanol and (R)- and (S)-arundic acids.
Magnetization of glassy Co-B alloys (1979)

By using a chill-casting technique, binary Co100−xBx alloys have been made for the boron content x between 10 and 31. The alloys with 14 ?x?29 are found to be noncrystalline, others being partially crystalline. The saturation magnetic moment per Co atom varies linearly from 1.49 μB at x=14 to 0.98 μB at x=29. At x=25, we find μs=1.09 μB which is close to μs=1.11 μB for the crystalline Co3B. The ferromagnetic Curie temperature, ϑf, is above the crystallization temperature of the material for x &lt; 27 and is estimated to vary from about 780 K for x=22 to 670 K for x=29, giving a value of ϑf = 725 K for x=25. This value is close to ϑf = 747 K for the crystalline Co3B. Other evidence is given that the magnetic properties of glassy Co-B alloys differ very little from those of the crystalline counterparts, being quite different from the glassy Fe-B case reported previously.
Generalized double‐acquisition imaging for radiofrequency inhomogeneity mitigation in high‐field MRI: Experimental proof and performance analysis (2011)

Transmit arrays have been developed to compensate for radiofrequency inhomogeneities in high-field MRI using different excitation schemes. They can be classified into static or dynamic shimmings depending on the target: homogenizing the radiofrequency field directly or homogenizing the flip angle distribution using the Bloch equation. We have developed an intermediate solution to compare shimming performances between different transmit arrays. This solution, called generalized double-acquisition imaging, is easier to implement than most dynamic shimming methods and offers more degrees of freedom than static shimmings. It uses two acquisitions so that the second acquisition complements the excitation of the first one to obtain by superposition an image that minimizes radiofrequency artefacts. For validation, the method is demonstrated experimentally for a gradient echo sequence on a spherical homogeneous phantom and by simulation on a human head model.
Total Synthesis of Sarcodictyins A and B (1998)

The total synthesis of cytotoxic marine natural products possessing tubulin polymerization and microtubule stabilization properties, sarcodictyins A (7) and B (8), is described. Two related approaches to these target molecules have been developed, both utilizing (+)-carvone (9) as starting material. The first approach involves a stereoselective construction of acetylenic aldehyde 27 (Scheme 2) while the second approach proceeds through a more direct but less selective sequence to the similar intermediate 36 (Scheme 3). Both strategies involve ring closures of the acetylenic aldehyde precursors to 10-membered rings under basic conditions followed by elaboration and selective reduction of the acetylenic linkage to a cis double bond. This promotes bridging to form the required tricyclic skeleton of the sarcodictyins (27 → 37 → 38 → 39 → 4, Scheme 4 and 37 → 44 → 45 → 46 → 47 → 42, Scheme 5) and (36 → 48 → 45, Scheme 6). Installation of the (E)-N(6‘)-methylurocanic acid residue was achieved by esterification with mixed anhydride 52, while the C-3 ester moieties were installed by standard deprotection, oxidation, and esterification procedures.
Synthesis, Antiproliferative, and Antiviral Evaluation of Certain Acyclic 6-Substituted Pyrrolo[2,3-<i>D</i>]-pyrimidine Nucleoside Analogs Related to Sangivamycin and Toyocamycin (1992)

Abstract A number of 6-substituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine and 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidine derivatives related to the nucleoside antibiotics toyocamycin and sangivamycin were prepared and tested for their biological activity. Treatment of 2-amino-5-bromo-3,4-dicyanopyrrole (2) with triethylorthoformate, followed by alkylation via the sodium salt method with either 2-(acetoxyethoxy)methyl bromide or (1,3-diacetoxy-2-propoxy)methyl bromide, furnished the corresponding N-substituted pyrroles 3a and 3b. These compounds were then smoothly converted to the requisite deprotected 4-amino-6-bromopyrrolo[2,3-d]-pyrimidine-5-carbonitriles 5a and 5b (toyocamycin analogs) by methanolic ammonia. The 6-amino-derivatives were obtained by a displacement of the bromo group with liquid ammonia. Conventional functional group transformations involving the 5-cyano group furnished the 5-carboxamide (sangivamycin) and 5-thioamide analogs. Compounds substituted at the 7-position with a ribosyl moiety were active against human cytomegalovirus (HCMV) at micromolar concentrations, but the apparent activity was not selective. The 7-ribosyl compounds also had no activity against human immunodeficiency virus (HIV), though they were all cytotoxic. The new compounds were also evaluated against HCMV, herpes simplex virus type I (HSV-1), HIV, and also for their ability to inhibit the growth of L1210 murine leukemic cells in vitro. None of these compounds with (2-hydroxyethoxy)methyl substituents or 7-(1,3-dihydroxy-2-propoxy)methyl substituent at N-7 showed significant cytotoxicity toward L1210, or toward uninfected human foreskin fibroblasts (HFF cells), and KB cells. Nor were they cytotoxic in human lines CEM or MT2. Only compound 4a was found to be active against HCMV, having an IC50 of 32 μM.
Oligonucleotide probe for detection and identification of Campylobacter pylori (1989)

We have developed a novel and practical DNA-RNA hybridization assay for the detection and identification of Campylobacter pylori in the gastric mucosa. This technique utilizes a [32P]ddATP-labeled synthetic oligonucleotide probe complementary to a nucleotide sequence present in C. pylori 16S rRNA. This probe is very sensitive and reacted with all 23 strains of C. pylori tested. It is also highly specific, since there was no cross-reactivity with the heterologous organisms Campylobacter coli, C. fetus subsp. fetus, C. jejuni, and C. laridis or with Escherichia coli. Hybridization of the oligonucleotide probe with C. pylori RNA was completely inhibited by treatment of the membrane filters with RNase but not DNase. Although a gastric mucosa tissue homogenate slightly inhibited the hybridization, as few as 10(4) C. pylori cells could be detected even in the presence of 5 mg of gastric mucosa. Gastric biopsy specimens obtained from patients referred for upper gastrointestinal tract endoscopy were tested for C. pylori infection by direct oligonucleotide hybridization, and the results were compared with those of bacteriological cultures, the urease test, and histological observations. A comparison of the urease test and the oligonucleotide hybridization results showed an excellent correlation between the two methods. The clinical usefulness of this oligonucleotide-RNA hybridization method is discussed.
Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains (2017)

A protein structure-guided drug design approach was employed to develop small molecule inhibitors of the BET family of bromodomains that were distinct from the known (+)-JQ1 scaffold class. These efforts led to the identification of a series of substituted benzopiperazines with structural features that enable interactions with many of the affinity-driving regions of the bromodomain binding site. Lipophilic efficiency was a guiding principle in improving binding affinity alongside drug-like physicochemical properties that are commensurate with oral bioavailability. Derived from this series was tool compound <b>FT001</b>, which displayed potent biochemical and cellular activity, translating to excellent in vivo activity in a mouse xenograft model (MV-4-11).
Numerical Simulation of Terrestrial Radiation over a Snow Cover (2014)

Abstract The intensity of terrestrial gamma radiation is a function of a number of parameters: emissivity and spatial distribution of the radioactive material in the soil, snow/water cover above ground, soil moisture content, type, and height above ground of the detector. Thus, the conversion of gamma measurements into reliable information must be based on a solid knowledge of the behavior of the gamma detector under different conditions. Such a detector, using a cylindrical NaI(Tl) crystal, was developed to remotely and automatically provide information on snow water equivalent (SWE) and soil moisture content ( M ). It became rapidly obvious that the behavior of the detector [gamma monitor (GMON)] over an infinite source could not be exactly reproduced in a laboratory. Therefore, a relatively simple model to simulate the behavior of GMON and to establish the relevant data analysis algorithms was conceived. This paper presents the basic assumptions for developing the model, the resulting algorithms, a comparison with field measurements, and some useful information on how GMON reacts to various field conditions.
Measurement of cross relaxation rates between selected nucleus pairs in NMR spectroscopy (1992)

This method measures cross relaxation rates in highly resolving NMR spectroscopy, where the sample substance is dissolved in a liq. and has nuclei A and X which have different chem. shifts WA and WX in a homogeneous static magnetic field Bo in the direction of the z-axis. The orientation of the longitudinal components I2A and I2X bring about the magnetization vectors IA and IX of the nuclei A and X during a time interval tan and irradn. with a constructed high-frequency field. Subsequently a longitudinal magnetization is conducted through a suitable high-frequency pulse sequence in a transverse magnetization which produces a high-frequency signal which is sensed by a detector. The constructed high-frequency field is formed from >=2 weak selective partial fields which have selected frequencies such that the magnetization vectors IA and IX are mixed in a synchronous mutation motion for all remaining nuclear spin remaining unaffected for the sample substance. Through the difference of the decay rates, the cross relaxation rates are detd. and from this the internuclear distance between the chosen nuclei. [on SciFinder (R)]
Polymer Zwitterions with Phosphonium Cations (2021)

Polymer zwitterions are of interest for numerous applications, many of which stem from their antifouling properties when used as hydrophilic coatings. However, the chemical compositions of polymer zwitterions remain limited, with synthetic variants most typically comprising ammonium cations. This manuscript describes the synthesis of novel phosphonium-based zwitterionic monomers, accessed by ring opening of substituted propane sultones with aliphatic and aromatic phosphines, and their polymerization by controlled free radical methods. Interestingly, the resultant polymeric phosphonium sulfonates proved soluble in numerous organic solvents, distinguishing them from the solution properties of more typical hydrophilic polymer zwitterions, with tunable and switchable properties made possible by selection of phosphonium R groups. Block copolymers prepared from these tailored phosphonium sulfonate zwitterions highlight their diverse range of solubility and amenability to aqueous polymer assembly.