gebhart/patrepeval huggingface dataset:
Dynamic, three‐dimensional optical tracking of an ablative laser beam (2005)

Surgical resection remains the treatment of choice for brain tumors with infiltrating margins but is currently limited by visual discrimination between normal and neoplastic marginal tissues during surgery. Imaging modalities such as computed tomography, magnetic resonance, positron emission tomography, and optical techniques can accurately localize tumor margins. We believe coupling the fine resolution of current imaging techniques with the precise cutting of midinfrared lasers through image-guided neurosurgery can greatly enhance tumor margin resection. This paper describes a feasibility study designed to optically track in three-dimensional space the articulated arm delivery of a noncontact ablative laser beam. To enable optical tracking of the laser beam focus, infrared-emitting diodes (IREDs) were attached to a handpiece machined for the distal end of the articulated arm of a surgical carbon dioxide laser. Crosstalk between the ablative laser beam and the tracking diodes was measured. The geometry of the adapted laser handpiece was characterized to track an externally attached passive tip and the laser beam focus. Target localization accuracies were assessed for both instrument points-of-interest and the sources of tracking errors were investigated. Stray infrared laser light did not affect optical tracking accuracy. The mean target registration errors while optically tracking the laser handpiece with a passive tip and the laser beam focus were 1.31+/-0.50 mm and 2.31+/-0.92 mm, respectively, and were equivalent to the errors tracking a 24-IRED pen probe from Northern Digital in a side-by-side comparison. The majority of error during ablation tracking derived from registration accuracy between physical space and the defined space of the ablation phantom and from an inability to freehand align the laser focus with the target in a consistent manner. While their magnitudes depend on spatial details of the tracking setup (e.g., number and distribution of fiducial points, working distance from the camera, etc.), these errors are inherent to any freehand laser surgery.
1-Methylcyclopropene Increases Storability and Shelf Life in Climacteric and Nonclimacteric Plums (2003)

The effect of 1-methylcyclopropene (1-MCP) at three different doses (0.25, 0.50, and 0.75 microL L(-1)) on the ripening processes of a climacteric, cv. Santa Rosa, and a suppressed climacteric type, cv. Golden Japan, plum was studied. For both cultivars, positive effects were observed in terms of inhibition of ethylene production and delays of the physical, chemical, and biochemical changes associated with ripening. 1-MCP-treated plums were firmer with lower weight loss, reduced degrees Brix/titratable acidity ratios, and lower color changes during cold storage and subsequent shelf life at 20 degrees C than controls. For most factors, the effectiveness of 1-MCP was dose-dependent in Santa Rosa but dose-independent for Golden Japan.
Predicting blood transfusion using automated analysis of pulse oximetry signals and laboratory values (2015)

Epidemiologic/prognostic study, level III.
A human-inspired object handover controller (2013)

In this paper, we present a novel controller for safe, efficient, and intuitive robot-to-human object handovers and a set of experiments to evaluate user responses to the robot’s handover behavior. The controller enables a robot to mimic human behavior by actively regulating the applied grip force according to the measured load force during a handover. We provide an implementation of the controller on a Willow Garage PR2 robot, demonstrating the feasibility of realizing our design on robots with basic sensor/actuator capabilities. A user study comparing four variations of our controller shows that our design yields both human-like and human-preferred object handovers.
(Pyrazolato)gold Complexes Showing Room-Temperature Columnar Mesophases. Synthesis, Properties, and Structural Characterization (1998)

Mesogenic (pyrazolato)gold complexes of formula [Au(pz)]3 (pz = 3,5-bis(3‘,4‘-di-n-decyloxyphenyl)pyrazole (1), 3-(3‘,4‘,5‘-tri-n-decyloxyphenyl)-5-(3‘‘,4‘‘-di-n-decyloxyphenyl)pyrazole (2), 3-(2‘,3‘,4‘-tri-n-decyloxyphenyl)-5-(3‘‘,4‘‘,5‘‘-tri-n-decyloxyphenyl)pyrazole (3), 3,5-bis(3‘,4‘,5‘-tri-n-decyloxyphenyl)pyrazole (4)) have been prepared by reaction of the potassium salts of the nonmesogenic pyrazolate ligands with [AuCl(tht)] (tht = tetrahydrothiophene) in a 1:1 molar ratio. All these compounds show columnar mesophases that remain stable, at room temperature, for long periods of time. The formation of isomers for the nonsymmetrical derivativesdetected by spectroscopic studiesare suggested to be responsible for the subtle changes observed in the transition temperatures. Powder X-ray diffraction measurements show clearly that the supramolecular columnar arrangement appears in the crystalline solids as well as in the mesomorphic phase. An analogue of the mesogenic trinuclear complexes 1−4, having a methoxy group at the phenyl substituents of the pyrazolate ligands, [Au{3,5-(MeOPh)2Pz}]3 (5), has been synthesized and characterized by an X-ray single-crystal diffraction experiment. The molecular structure of 5 is based on a nine-membered metallacycle core. The whole molecule exhibits a rough planarity that favors a crystalline structure formed from columnar arrangements of trinuclear complexes. A simple and clear relationship could be established between the solid-state crystal structure of 5 and the X-ray-deduced structure of the mesophases.
Resolution of deep eudicot phylogeny and their temporal diversification using nuclear genes from transcriptomic and genomic datasets (2017)

Summary Explosive diversification is widespread in eukaryotes, making it difficult to resolve phylogenetic relationships. Eudicots contain c . 75% of extant flowering plants, are important for human livelihood and terrestrial ecosystems, and have probably experienced explosive diversifications. The eudicot phylogenetic relationships, especially among those of the Pentapetalae, remain unresolved. Here, we present a highly supported eudicot phylogeny and diversification rate shifts using 31 newly generated transcriptomes and 88 other datasets covering 70% of eudicot orders. A highly supported eudicot phylogeny divided Pentapetalae into two groups: one with rosids, Saxifragales, Vitales and Santalales; the other containing asterids, Caryophyllales and Dilleniaceae, with uncertainty for Berberidopsidales. Molecular clock analysis estimated that crown eudicots originated c . 146 Ma, considerably earlier than earliest tricolpate pollen fossils and most other molecular clock estimates, and Pentapetalae sequentially diverged into eight major lineages within c . 15 Myr. Two identified increases of diversification rate are located in the stems leading to Pentapetalae and asterids, and lagged behind the gamma hexaploidization. The nuclear genes from newly generated transcriptomes revealed a well‐resolved eudicot phylogeny, sequential separation of major core eudicot lineages and temporal mode of diversifications, providing new insights into the evolutionary trend of morphologies and contributions to the diversification of eudicots.
Monolithic integration of lasers with FET and bipolar transistors in inversion channel technology (1993)

The first monolithic integration of lasers with HFETs and bipolar transistors in inversion channel technology is presented. A threshold current of 2mA and a slope efficiency of 8mW/mA was obtained for the bipolar/laser circuit. The transfer characteristic for the integrated HFET/laser converts voltage to output power. The output efficiency for this circuit was 2mW/V, where the voltage was divided across the laser and the HFET.
High thermally conductive PLA based composites with tailored hybrid network of hexagonal boron nitride and graphene nanoplatelets (2015)

Bio‐based polymers and multifunctional polymeric composites are promising for the development of new environmentally sustainable materials and are becoming increasingly popular compared to their oil based counterparts. This research aims to develop new multifunctional bio‐based polymer composites with improved thermal conductivity and tailored electrical properties to be used as heat management materials in the electronics industry. A series of parametric studies were conducted to clarify the science behind the hybrid composites' behavior and their structure‐to‐property relationships. Using bio‐based polymers [e.g., polylactic acid (PLA)] as the matrix, heat transfer networks were developed and structured by embedding hexagonal boron nitride (hBN) and graphene nanoplatelets (GNP) in a PLA matrix. The effects of random uniform thermal hybrid networks of hBN‐GNP on improving the effective thermal conductivity ( k eff ) of produced composites were studied and compared. Composites were characterized with respect to physical, thermal, electrical, and mechanical properties for practical application in the electronics industry. The use of high thermally conductive hybrid filler systems, with optimized filler content, was found to promote the composites' effective thermal conductivity to more than 12 times over neat PLA. The thermally conductive composite is expected to provide unique opportunities to injection mold three‐dimensional, net‐shape, lightweight, and eco‐friendly microelectronic enclosures with superior heat dissipation performance. POLYM. COMPOS., 37:2196–2205, 2016. © 2015 Society of Plastics Engineers
Risk and Disease (2008)

The way that diseases such as high blood pressure (hypertension), high cholesterol, and diabetes are defined is closely tied to ideas about modifiable risk. In particular, the threshold for diagnosing each of these conditions is set at the level where future risk of disease can be reduced by lowering the relevant parameter (of blood pressure, low-density lipoprotein, or blood glucose, respectively). In this article, I make the case that these criteria, and those for diagnosing and treating other "risk-based diseases," reflect an unfortunate trend towards reclassifying risk as disease. I closely examine stage 1 hypertension and high cholesterol and argue that many patients diagnosed with these "diseases" do not actually have a pathological condition. In addition, though, I argue that the fact that they are risk factors, rather than diseases, does not diminish the importance of treating them, since there is good evidence that such treatment can reduce morbidity and mortality. For both philosophical and ethical reasons, however, the conditions should not be labeled as pathological. The tendency to reclassify risk factors as diseases is an important trend to examine and critique.
An overlapping window decorrelating multiuser detector for DS-CDMA radio channels (2001)

A new multiuser detector for direct-sequence code-division multiple-access communication systems is described. The proposed detector divides the received signal stream into a number of overlapping windows and decorrelates them window by window. This scheme is justified by an analysis of the convergence and decay rate of the impulse response. Based on the results, a signal-adapted criterion is developed which enables one to determine the window length according to the near-far situation of a practical system. A performance analysis and simulation results show that a small to moderate window length is usually sufficient to yield a performance that is close to or even better than that of the ideal decorrelating detector.
Nutrient digestibility and performance responses of growing pigs fed phytase- and xylanase-supplemented wheat-based diets1 (2008)

Three experiments were conducted to evaluate the effect of supplementing phytase and xylanase on nutrient digestibility and performance of growing pigs fed wheat-based diets. In Exp. 1, 10 diets were fed to 60 pigs from 20 to 60 kg of BW to determine the effect of combining phytase and xylanase on apparent total tract digestibility (ATTD) of nutrients and growth performance. The 10 diets included a positive control diet (PC; 0.23% available P; 0.60% Ca) and a negative control diet (NC; 0.16% available P; 0.50% Ca) supplemented with phytase at 0, 250, and 500 fytase units (FTU)/kg and xylanase at 0, 2,000, and 4,000 xylanase units (XU)/kg in a 3 x 3 factorial arrangement. In Exp. 2, 6 ileally cannulated barrows (initial BW = 35.1 kg) were fed 4 wheat-based diets in a 4 x 4 Latin square design, with 2 added columns to determine the effect of combining phytase and xylanase on apparent ileal digestibility (AID) of nutrients. The 4 diets were NC (same as that used in Exp. 1) or NC supplemented with phytase at 500 FTU/kg, xylanase at 4,000 XU/kg, or phytase at 500 FTU/kg plus xylanase at 4,000 XU/kg. In Exp. 3, 36 barrows (initial BW = 55.5 kg) were fed 4 diets based on prepelleted (at 80 degrees C) and crumpled wheat for 2 wk to determine the effect of phytase supplementation on ATTD of nutrients. The 4 diets fed were a PC (0.22% available P; 0.54% Ca) and a NC (0.13% available P; 0.43% Ca) alone or with phytase at 500 or 1,000 FTU/kg. All diets in the 3 experiments contained Cr(2)O(3) as an indigestible marker. No synergistic interactions were detected between phytase and xylanase on any of the response criteria measured in Exp. 1 or 2. There were no dietary effects on growth performance in Exp. 1. In Exp. 1, phytase at 250 FTU/kg increased the ATTD of P and Ca by 51 and 11% at 20 kg of BW or by 54 and 10% at 60 kg of BW, respectively, but increasing the level of phytase to 500 FTU/kg only increased (P < 0.05) ATTD of P at 20 kg of BW. In Exp. 2, phytase at 500 FTU/kg increased (P < 0.05) the AID of P and Ca by 21 and 12%, respectively. In Exp. 3, phytase at 500 FTU/kg improved (P < 0.05) ATTD of P by 36%, but had no further effect at 1,000 FTU/kg. Xylanase at 4,000 XU/kg improved (P < 0.05) AID of Lys, Leu, Phe, Thr, Gly, and Ser in Exp. 2. In conclusion, phytase and xylanase improved P and AA digestibilities, respectively, but no interaction between the 2 enzymes was noted.
Detecting middle ear fluid using smartphones (2019)

The presence of middle ear fluid is a key diagnostic marker for two of the most common pediatric ear diseases: acute otitis media and otitis media with effusion. We present an accessible solution that uses speakers and microphones within existing smartphones to detect middle ear fluid by assessing eardrum mobility. We conducted a clinical study on 98 patient ears at a pediatric surgical center. Using leave-one-out cross-validation to estimate performance on unseen data, we obtained an area under the curve (AUC) of 0.898 for the smartphone-based machine learning algorithm. In comparison, commercial acoustic reflectometry, which requires custom hardware, achieved an AUC of 0.776. Furthermore, we achieved 85% sensitivity and 82% specificity, comparable to published performance measures for tympanometry and pneumatic otoscopy. Similar results were obtained when testing across multiple smartphone platforms. Parents of pediatric patients (<i>n</i> = 25 ears) demonstrated similar performance to trained clinicians when using the smartphone-based system. These results demonstrate the potential for a smartphone to be a low-barrier and effective screening tool for detecting the presence of middle ear fluid.
Z - imaging of Xe(M) and Xe(L) emissions from channelled propagation of intense femtosecond 248 nm pulses in a Xe cluster target (1996)

The spatial image of the spectrum of Xe(M) and Xe(L) emissions produced by the development of stable channelled propagation of intense femtosecond ( fs) 248 nm pulses propagating through a gas-phase Xe cluster target has been obtained. Analysis (i) shows that the observed channel length exceeds 20 Rayleigh ranges, (ii) reveals enhanced emission from the channel by very highly excited species such as Xe ions having double 2p-vacancies Å), (iii) gives spectral evidence for a substantial departure of the excitation from conditions of thermal equilibrium in the channel, (iv) confirms earlier studies which indicated the development of intensities of in the channel, and (v) provides additional evidence for the role of an anomolously strong multiphoton coupling in the generation of the observed X-ray emission.
Analysis of new anisotropic conductive film (ACF) (2005)

This paper designs a new multilayered particle anisotropic conductive film (ACF) compound. Using the particle-reinforced composite model and probability theory, the novel ACF compound is compared with three traditional ACFs having the same particle volume fraction. The particle-reinforced model applies the concept of bonded and debonded structures in the interfaces between the adhesive resin and the particles. The elastic modulus of the particle-reinforced ACF is a function of the particle volume fraction and the bonded condition. In the failure model, probability theory is used to calculate the probability of opening and bridging. The volume fraction of the conductive particles plays an important role in determining the optimal ACF design. The current results indicate that the flip chip packaging performed using the novel multilayered particle ACF compound (particles distributed in the top/bottom surface layers) exhibits superior particle-reinforcement properties and a lower failure probability than traditional ACFs. The improved understanding of reinforcement mechanisms and failure probability developed by this study facilitates the enhanced design of novel ACF compounds.
Allium sativum (garlic) treatment for murine transitional cell carcinoma (1997)

The significant antitumor efficacy of subcutaneous and oral AS warrants further investigation and suggests that AS may provide a new and effective form of therapy for transitional cell carcinoma of the bladder.
Hot compaction of polyethylene naphthalate (2004)

Abstract In this article, we describe the production of single polymer composites from polyethylene naphthalate (PEN) multifilaments by using the hot compaction process. In this process, developed at Leeds University, highly oriented tapes or fibers are processed at a critical temperature such that a small fraction of the surface of each oriented element is melted, which on cooling recrystallizes to form the matrix of the composite. This process is, therefore, a way to produce novel high‐volume fraction polymer/polymer composites where the two phases are chemically the same material. A variety of experimental techniques, including mechanical tests and differential scanning calorimetry, were used to examine the mechanical properties and morphology of the compacted PEN sheets. Bidirectional (0/90) samples were made at a range of compaction temperatures chosen to span the melting range of the PEN multifilaments (268–276°C). Measurement of the mechanical properties of these samples, specifically the in‐plane modulus and strength, allowed the optimum compaction temperature to be ascertained (∼ 271°C), and hence, the optimum mechanical properties. The optimum compacted PEN sheets were found to have an initial modulus close to 10 GPa and a strength of just over 200 MPa. The glass transition temperature of the optimum compacted sheets was measured to be 150°C, nearly 40°C higher than compacted poly(ethylene terephthalate) (PET) sheets. In previous work on polypropylene and PET hot compacted materials, it proved instructive to envisage these materials as a composite where the original oriented multifilaments are regarded as the reinforcing phase, and the melted and recrystallized material are regarded as the matrix phase. Dynamic mechanical bending tests (DMTA) were used here to confirm this for PEN. DMTA tests were carried out on the original fibers and on a sample of completely melted material to determine the fiber and matrix properties, respectively. The composite properties were then predicted by using a simple rule of mixtures and this was found to be in excellent agreement with the magnitude and measured temperature dependence of the hot compacted PEN material. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 796–802, 2004
Low-energy inference machine with multilevel HfO<sub>2</sub> RRAM arrays (2019)

Recently, artificial intelligence reached impressive milestones in many machine learning tasks such as the recognition of faces, objects, and speech. These achievements have been mostly demonstrated in software running on high-performance computers, such as the graphics processing unit (GPU) or the tensor processing unit (TPU). Novel hardware with in-memory processing is however more promising in view of the reduced latency and the improved energy efficiency. In this scenario, emerging memory technologies such as phase change memory (PCM) and resistive switching memory (RRAM), have been proposed for hardware accelerators of both learning and inference tasks. In this work, a multilevel 4kbit RRAM array is used to implement a 2-layer feedforward neural network trained with the MNIST dataset. The performance of the network in the inference mode is compared with recently proposed implementations using the same image dataset demonstrating the higher energy efficiency of our hardware, thanks to low current operation and an innovative multilevel programming scheme. These results support RRAM technology for in-memory hardware accelerators of machine learning.
BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes (2017)

The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by actively proliferating Lgr5<sup>+</sup> stem cells. Bone morphogenetic protein (BMP) signalling represents one major counterforce that limits the hyperproliferation of intestinal epithelium, but the exact mechanism remains elusive. Here we demonstrate that epithelial BMP signalling plays an indispensable role in restricting Lgr5<sup>+</sup> stem cell expansion to maintain intestinal homeostasis and prevent premalignant hyperproliferation on damage. Mechanistically, BMP inhibits stemness of Lgr5<sup>+</sup> stem cells through Smad-mediated transcriptional repression of a large number of stem cell signature genes, including Lgr5, and this effect is independent of Wnt/β-catenin signalling. Smad1/Smad4 recruits histone deacetylase HDAC1 to the promoters to repress transcription, and knockout of Smad4 abolishes the negative effects of BMP on stem cells. Our findings therefore demonstrate that epithelial BMP constrains the Lgr5<sup>+</sup> stem cell self-renewal via Smad-mediated repression of stem cell signature genes to ensure proper homeostatic renewal of intestinal epithelium.
Simulation-based bug trace minimization with BMC-based refinement (2005)

Finding the cause of a bug can be one of the most time-consuming activities in design verification. This is particularly true in the case of bugs discovered in the context of a random simulation- based methodology, where bug traces, or counter-examples, may contain several hundred thousand cycles. In this work we propose Butramin, a bug trace minimizer. Butramin considers a bug trace produced by a random simulator or a semi-formal verification software and produces an equivalent trace of shorter length. Butramin applies a range of minimization techniques, deploying both simulation-based and formal methods, with the objective of producing highly reduced traces that still expose the original bug. We evaluated Butramin on a range of designs, including the publicly available picoJava microprocessor. Our experiments show that in most cases Butramin is able to reduce traces to a small fraction of their initial size, in terms of cycle length and signals involved.