gebhart/patrepeval huggingface dataset:
Experiences with SRL: an analysis of a frame-based knowledge representation (2018)

Robotics Institute
A Broad-Spectrum Antimicrobial Activity of<i>Bacillus subtilis</i>RLID 12.1 (2014)

In the present study, an attempt was made to biochemically characterize the antimicrobial substance from the soil isolate designated as RLID 12.1 and explore its potential applications in biocontrol of drug-resistant pathogens. The antimicrobial potential of the wild-type isolate belonging to the genus Bacillus was determined by the cut-well agar assay. The production of antimicrobial compound was recorded maximum at late exponential growth phase. The ultrafiltered concentrate was insensitive to organic solvents, metal salts, surfactants, and proteolytic and nonproteolytic enzymes. The concentrate was highly heat stable and active over a wide range of pH values. Partial purification, zymogram analysis, and TLC were performed to determine the preliminary biochemical nature. The molecular weight of the antimicrobial peptide was determined to be less than 2.5 kDa in 15% SDS-PAGE and in zymogram analysis against Streptococcus pyogenes. The N-terminal amino acid sequence by Edman degradation was partially determined to be T-P-P-Q-S-X-L-X-X-G, which shows very insignificant identity to other antimicrobial peptides from bacteria. The minimum inhibitory concentrations of dialysed and partially purified ion exchange fractions were determined against some selected gram-positive and gram-negative bacteria and some pathogenic yeasts. The presence of three important antimicrobial peptide biosynthesis genes ituc, fend, and bmyb was determined by PCR.
Specific effects of somatic GATA2 zinc finger mutations on erythroid differentiation (2022)

GATA2 zinc-finger (ZF) mutations are associated with distinct entities of myeloid malignancies. The specific distribution of these mutations points toward different mechanisms of leukemogenesis depending on the ZF domain affected. In this study, we compared recurring somatic mutations in ZF1 and ZF2. All tested ZF mutants disrupted DNA binding in vitro. In transcription assays, co-expression of FOG1 counteracted GATA2-dependent transcriptional activation, while a variable response to FOG1-mediated repression was observed for individual GATA2 mutants. In primary murine bone marrow cells, GATA2 wild-type (WT) expression inhibited colony formation, while this effect was reduced for both mutants A318T (ZF1) and L359V (ZF2) with a shift toward granulopoiesis. In primary human CD34<sup>+</sup> bone marrow cells and in the myeloid cell line K562, ectopic expression of GATA2 L359V, but not A318T or G320D, caused a block of erythroid differentiation accompanied by downregulation of GATA1, STAT5B, and PLCG1. Our findings may explain the role of GATA2 L359V during the progression of chronic myeloid leukemia and the collaboration of GATA2 ZF1 alterations with CEBPA double mutations in erythroleukemia.
Sun protection education in the United States: what we know and what needs to be taught. (2003)

The incidence of skin cancers in the United States is rising. This has correlated with a life-time of sun exposure and cumulative damage of repetitive sun-related injuries such as tanning and sunburning. It is estimated that 80% of sun damage occurs before the age of 18 years. This relates to excessive tanning, blistering sunburns, and ineffective sun protection. It has been demonstrated that children can be taught to protect themselves from the sun. However, teaching of sun protection needs to begin at an early age. Such education requires that parents enforce protection in the household and through their actions in sunny situations. It has become apparent from the literature in the United States that we have made strides in sun education, but we have not yet instituted an effective nationwide education plan. This article reviews the data we have in the United States on sun protection, with a focus toward helping to design better education programs for the future. Based on the literature, it would seem that sun education should combine teaching mothers about sun protection in the nursery and teaching schools how to educate youngsters on the need for sun protection, beginning in nursery school. Improvements in education will have a latency of many years for reducing skin cancer incidence but will be an excellent investment in the future cutaneous health of today's children.
Loss of HLA‐A,B,C and <i>de novo</i> expression of HLA‐D in colorectal cancer (1986)

One hundred primary colorectal carcinomas and 19 metastases were studied for the expression of HLA-A,B,C and HLA-D antigens using monoclonal antibodies (MAbs) against framework determinants and a sensitive immunoperoxidase technique on frozen sections. With MAb W6/32, 65 tumors were intensely stained for HLA-A,B,C; 22 showed a reduced staining intensity, in 5 carcinomas a minor or major subset of the tumor cells lacked HLA-A,B,C, and in 8 cases all tumor cells were unreactive. The loss of HLA-A,B,C was inversely correlated with the degree of differentiation. No relation was found to type, stage and site of the tumor, or to age and sex of the patients. With MAb 2.06, 58 tumors were HLA-D negative, 20 exhibited small positive foci, 19 showed a patchy staining pattern, and 3 were homogeneously HLA-D positive. There was no apparent correlation between HLA-D expression and any of the clinico-pathological features mentioned, nor was it related to the loss of HLA-A,B,C. About half of the metastases displayed the same staining pattern for HLA-A,B,C and -D as the respective primary tumors. The remainder differed from the primary carcinoma by gain or loss of HLA antigens.
Attacks on Peer-to-Peer Networks (2005)

In this thesis, we collect information about known attacks on P2P networks. We try to classify them as well as study the different possible defense mechanisms. As a case study, we take Freenet, a third generation P2P system, which we deeply analyze, including simulating possible behaviors and reactions. Finally, we draw several conclusions about what should be avoided when designing P2P applications and give a new possible approach to making a P2P application as resilient as possible to malicious users.
Neural network analysis of nondestructive evaluation patterns (1992)

Nondeabuctive evaluation (NDE) teelmiques are used to verify the integrity of aircraft parts prior to assembly, during assembly, and during maintenance operations. These tec.hniqueaare used to ensure that matedal flaws do not exist in critical structural parts. Current NDE technologies are being challenged by demands for increased aeeuracy, s- reliability, and cost effectiveness.
Synthesis of Boroxifen, A <i>N</i><i>ido-</i>Carborane Analogue of Tamoxifen (2001)

A nido-carborane analogue of tamoxifen, the widely employed breast cancer therapy agent, was prepared as an archetype of a potential new class of antiestrogen and boron neutron capture therapy agent in which the carborane is incorporated within the framework of the parent compound. The carborane was introduced through the reaction of 6,9-bis(acetonitrile)decaborane with a unique and highly conjugated ene-yne, which was prepared stereoselectively. NMR spectroscopy and a crystal structure of a key intermediate, the carborane analogue of chloro-tamoxifen, demonstrated the structural similarities between the tamoxifen carboranes and their corresponding phenyl analogues.
Metropolis Instant Radiosity (2007)

Abstract We present Metropolis Instant Radiosity (MIR), an unbiased algorithm to solve the Light Transport problem. MIR is a hybrid technique which consists in representing the incoming radiance field by a set of Virtual Point Lights (V PLs) and in computing the response of all sensors in the scene (i.e. camera captors) by accumulating their contributions. In contrast to other similar approaches, we propose to sample the VPLs with an innovative Multiple‐try Metropolis‐Hastings (MTMH) Algorithm: the goal is to build an efficient, aggressive, and unconditionally robust variance reduction method that works well regardless of the scene layout. Finally, we present a fast ray tracing implementation using MIR and show how our complete rendering pipeline can produce high‐quality and high‐resolution pictures in a few seconds.
Fabrication of Hydroxyapatite–Zirconia Composites for Orthopedic Applications (2006)

Dense hydroxyapatite–zirconia (HAp–ZrO 2 ) composites are expected to have desired mechanical and biological properties for orthopedic applications. However, due to some processing problems, to date, this material can only be prepared by special techniques. In this paper, we report for the first time a facile route to prepare HAp–ZrO 2 composites. Initially, HAp and ZrO 2 powders were dispersed in aqueous media with polyacrylic acid and glutamic acid as the dispersants. The slurries exhibited a well‐stabilized state at a high solid content (>50 vol%) and therefore green samples with high density (>60%) can be obtained after slip casting. These HAp–ZrO 2 green samples can be easily densified by pressureless sintering at 1450°C with 2 h holding. After sintering, only hydroxyoxyapatite Ca 10 (PO 4 ) 6 O x (OH) 2(1− x ) (HOA), ZrO 2 , and trace amounts of α‐tricalcium phosphate phases were detected. No obvious reactions between HAp and ZrO 2 phase were observed. The HAp–ZrO 2 samples showed excellent mechanical and biological properties. For 40 vol% HAp–60 vol% ZrO 2 samples sintered at 1450°C, the flexural strength and toughness were 220 MPa and 4.37 MPa·m 1/2 , respectively. In addition, we observed the attachment, spreading, and proliferation of mesenchymal stem cells on the HAp–ZrO 2 samples' surface. The results showed that the proposed colloidal processing and pressureless sintering process is feasible for preparing HAp–ZrO 2 composites with high mechanical properties and promising bioactivity for orthopedic applications.
In Vitro and In Vivo Activities of Aminoadamantane and Aminoalkylcyclohexane Derivatives against<i>Trypanosoma brucei</i> (2001)

We reported recently that the bloodstream form of the African trypanosome, Trypanosoma brucei, is sensitive to the anti-influenza virus drug rimantadine. In the present report we describe the trypanocidal properties of a further 62 aminoadamantane and aminoalkylcyclohexane derivatives. Seventeen of the compounds were found to be more active than rimantadine, with four inhibiting growth in vitro of T. brucei by >90% at concentrations of 1 microM. The most active derivative (1-adamantyl-4-amino-cyclohexane) was about 20 to 25 times more effective than rimantadine. We observed a correlation between structural features of the derivatives and their trypanocidal properties; hydrophobic substitutions to the adamantane or cyclohexane rings generally enhanced activity. As with rimantadine, the activity in vitro varied with the pH. T. brucei was more sensitive in an alkaline environment (including a normal bloodstream pH of 7.4) and less sensitive under acidic conditions. Tests for activity in vivo were carried out with a mouse model of infection with a virulent strain of T. brucei. Although the parasitemia was not eliminated, it could be transiently suppressed by >98% with the most active compounds tested. These results suggest that aminoadamantane derivatives could have potential as a new class of trypanocidal agents.
Functional Property of la‐Positive T Cells in Peripheral Blood from Patients with Systemic Lupus Erythematosus (1985)

Ia-positive (Ia+) T cells in peripheral blood and their functional property were examined in patients with systemic lupus erythematosus (SLE). Binding of specific monoclonal antibodies was assessed by indirect immunofluorescence. Functional study of Ia+ T cells was carried out in coculture experiments by measuring the IgG secreted into the culture supernatant. We found that the percentage of Ia+ T cells in peripheral blood from patients with SLE was raised and the rise correlated positively with serum gamma globulin and IgG level. The elevation was further increased after stimulation with DNA in vitro, indicating the presence of DNA-sensitive T cells. Functionally, Ia+ T cells acted as helper cells in spontaneous IgG synthesis of SLE B cells, and were enriched in the OKT4 subset. These results indicate that SLE T cells are activated in vivo and that the Ia+ T cells may play a crucial role in the immunoregulatory function. Accordingly, demonstration of Ia antigens on T cells by monoclonal antibody may provide a useful tool for the measurement of immunological activity in patients with SLE.
Teaching for life? Midlife narratives from female classroom teachers who considered leaving the profession (2010)

ABSTRACT Career decision-making research has focused primarily on occupation change as a discrete event and emphasised occupational mobility. Not all of those who consider changing occupation do so though, and this study explored the narrative accounts of nine female teachers who had considered leaving the profession, but remained teaching at midlife. Narrative plotlines illustrated how this decision-making process evolved across the career span and revealed individual experiences ranging from reconciliation to on-going disaffection with teaching. Thematic analysis identified factors associated with occupational embeddedness in understanding why these women stayed and the potential for embedding issues to constrain women's occupational mobility. Implications for career counselling include exploring occupational decision-making across the career span, recognising the impact of embedding forces on women's teaching careers and supporting those who feel unable to leave this demanding occupation.
Two-photon volumetric optical disk storage systems experimental results and potentials (2003)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text E. P. Walker, Y. Zhang, A. Dvornik, P. Rentzepis, and S. Esener, "Two-photon volumetric optical disk storage systems experimental results and potentials," in Optics in Computing, A. Sawchuk, ed., Vol. 90 of OSA Trends in Optics and Photonics (Optica Publishing Group, 2003), paper OFB2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Continuously tunable narrow-band terahertz generation with a dielectric lined waveguide driven by short electron bunches (2019)

A continuously tunable narrow-band terahertz source based on Cherenkov wakefield generation in a dielectric lined waveguide driven by short sub-picosecond electron bunches has been experimentally demonstrated. A large tunability range of 0.55--0.95 THz was achieved by implementing the waveguide design as a planar structure with variable 0.15--1.10 mm gap and thin $25\text{ }\text{ }\ensuremath{\mu}\mathrm{m}$ dielectric layers. The source operates essentially in a single mode regime with higher order modes of negligible intensity. THz pulse energy was measured across the tunable range and compared with theory.
A Liquid Chromatography-Mass Spectrometry Method for the Simultaneous Measurement of 15 Urinary Estrogens and Estrogen Metabolites: Assay Reproducibility and Interindividual Variability (2008)

Our high-performance liquid chromatography-tandem mass spectrometry method for measuring 15 urinary EM is highly reproducible, and the range of EM concentrations in each menstrual/sex group is quite large relative to assay variability. Whether these patterns persist in blood and target tissues awaits further development and application of this method.
Selecting a Reference High Resolution for Fingerprint Recognition Using Minutiae and Pores (2010)

High-resolution automated fingerprint recognition systems (AFRSs) offer higher security because they are able to make use of level-3 features, such as pores, that are not available in lower resolution ( <; 500-dpi) images. One of the main parameters affecting the quality of a digital fingerprint image and issues such as cost, interoperability, and performance of an AFRS is the choice of image resolution. In this paper, we identify the optimal resolution for an AFRS using the two most representative fingerprint features: minutiae and pores. We first designed a multiresolution fingerprint acquisition device to collect fingerprint images at multiple resolutions and captured fingerprints at various resolutions but at a fixed image size. We then carried out a theoretical analysis to identify the minimum required resolution for fingerprint recognition using minutiae and pores. After experiments on our collected fingerprint images and applying three requirements for the proportions of minutiae and pores that must be retained in a fingerprint image, we recommend a reference resolution of 800 dpi. Subsequent tests have further confirmed the proposed reference resolution.
Causal source codes (1982)

Causal source codes are defined. These include quantizers, delta modulators, differential pulse code modulators, and adaptive versions of these. Several types of causal codes are identified. For memoryless sources it is shown that the optimum performance attainable by causal codes can be achieved by memoryless codes or by time-sharing memoryless codes. This optimal performance can be evaluated straightforwardly.
Structure-and-motion pipeline on a hierarchical cluster tree (2009)

This papers introduces a novel hierarchical scheme for computing Structure and Motion. The images are organized into a tree with agglomerative clustering, using a measure of overlap as the distance. The reconstruction follows this tree from the leaves to the root. As a result, the problem is broken into smaller instances, which are then separately solved and combined. Compared to the standard sequential approach, this framework has a lower computational complexity, it is independent from the initial pair of views, and copes better with drift problems. A formal complexity analysis and some experimental results support these claims.
Evaluation of a non-intrusive monitor to reduce falls in nursing home patients (2003)

High fall risk residents (n=47) from a single care home participated in this American study, evaluating a passive alarm (NOC.watch). Fifty percent of the study population had dementia. The alarm was a disposable credit-card size device that could either be attached to the skin or incorporated in clothing. Rising from a chair or bed caused an alarm to sound, alerting the resident and carers that assistance was required. Data on fall rate per 100 days before, during and after the intervention was collected. Qualitative data on skin integrity and resident acceptability was observed. During the seven-day intervention period one fall was reported, compared to 11 in the pre-test period and 17 in the post-test period. This represented a 91 per cent reduction in falls when wearing the passive alarm. Skin integrity was maintained in 98 per cent of cases. The authors assert the device’s effectiveness in reducing high-risk fall behaviour in a high-risk dementia population, but advocate the need for a larger randomised control trial. Six residents removed the device during the study, preferring to summon assistance themselves. This raises issues of patient efficacy and the need for passive alarm systems to be considered within a wider assessment process.
Online Model-Based Clustering for Crisis Identification in Distributed Computing (2010)

Large-scale distributed computing systems can suffer from occasional severe violation of performance goals; due to the complexity of these systems, manual diagnosis of the cause of the crisis is too slow to inform interventions taken during the crisis. Rapid automatic recognition of the recurrence of a problem can lead to cause diagnosis and informed intervention. We frame this as an online clustering problem, where the labels (causes) of some of the previous crises may be known. We give a fast and accurate solution using model-based clustering based on a Dirichlet process mixture; the evolution of each crisis is modeled as a multivariate time series. In the periods between crises we perform full Bayesian inference for the past crises, and as a new crisis occurs we apply fast approximate Bayesian updating. These inferences allow real-time expected-cost-minimizing decision making that fully accounts for uncertainty in the crisis labels and other parameters. We apply and validate our methods using simulated data and data from a production computing center with hundreds of servers running a 24/7 email-related application.
Free Energy Calculations on the Binding of Colchicine and Its Derivatives with the α/β-Tubulin Isoforms (2008)

Tubulin is the target for numerous small molecule ligands which alter microtubule dynamics leading to cell cycle arrest and apoptosis. Many of these ligands are currently used clinically for the treatment of several types of cancer, and they bind to one of three distinct binding sites within beta-tubulin (paclitaxel, vinca, and colchicine), all of which have been identified crystallographically. Unfortunately, serious side effects always accompany chemotherapy since these drugs bind to tubulin indiscriminately, leading to the death of both cancerous and healthy cells. However, the existence and distribution of divergent tubulin isoforms provide a platform upon which we may build novel chemotherapeutic drugs that can differentiate between different cell types and therefore reduce undesirable side effects. We report results of computational analysis that aims at predicting differences between the binding energies of a family of colchicine derivatives against 10 human alpha/beta-tubulin isoforms. Free energy perturbation method has been used in our calculations and the results provide a proof of principle by indicating significant differences both among the derivatives and between tubulin isoforms.
A recursive PVM implementation of an image segmentation algorithm with performance results comparing the HIVE and the Cray T3E (1999)

A recursive PVM (Parallel Virtual Machine) implementation of a high quality but computationally intensive image segmentation approach is described and the performance of the algorithm on the HIVE and on the Cray T3E is contrasted. The image segmentation algorithm, which is designed for the analysis of multispectral or hyperspectral remotely sensed imagery data, is a hybrid of region growing and spectral clustering that produces a hierarchical set of image segmentations based on detected natural convergence points. The HIVE is a Beowulf-class parallel computer consisting of 66 Pentium Pro PCs (64 slaves and 2 controllers) with 2 processors per PC (for 128 total slave processors) which was developed and assembled by the Applied Information Sciences Branch at NASA's Goddard Space Flight Center. The Cray T3E is a supercomputer with 512 available processors, which is installed at the NASA Center for Computational Science at NASA's Goddard Space Flight Center. Timing results on Landsat Multispectral Scanner data show that the algorithm runs approximately 1.5 times faster on the HIVE, even though the HIVE is some 86 times less costly than the Cray T3E.