gebhart/patrepeval huggingface dataset:
Marketing of Churches: An Empirical Study of Important Attributes (1996)

ABSTRACT This is an empirical study to identify the attributes or factors which determine worshippers' satisfaction in a church. The research instrument we used was a self administered questionnaire which was filled out by residents in Denton. The worshippers were asked to rate the importance as well as their satisfaction with the church they attend on four components of worship (i.e., church environment, pulpit ministry, music ministry, and congregational participation). The scales were tested for validity and reliability, and reduced to the necessary number of factors, using factor analysis. Regression on each of the components of worship was also done and analyzed. Further, an ANOVA procedure was done to find out if there are significant differences in the overall altitude and overall satisfaction based on the demographics of the congregation. It is hoped that the study will prove useful to churches so as to improve congregational worship.
Goertzel algorithm generalized to non-integer multiples of fundamental frequency (2012)

The article deals with the Goertzel algorithm, used to establish the modulus and phase of harmonic components of a signal. The advantages of the Goertzel approach over the DFT and the FFT in cases of a few harmonics of interest are highlighted, with the article providing deeper and more accurate analysis than can be found in the literature, including the memory complexity. But the main emphasis is placed on the generalization of the Goertzel algorithm, which allows us to use it also for frequencies which are not integer multiples of the fundamental frequency. Such an algorithm is derived at the cost of negligibly increasing the computational and memory complexity.
KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells (2014)

KAP1 (TRIM28) is a transcriptional regulator in embryonic development that controls stem cell self-renewal, chromatin organization, and the DNA damage response, acting as an essential corepressor for KRAB family zinc finger proteins (KRAB-ZNF). To gain insight into the function of this large gene family, we developed an antibody that recognizes the conserved zinc fingers linker region (ZnFL) in multiple KRAB-ZNF. Here, we report that the expression of many KRAB-ZNF along with active SUMOlyated KAP1 is elevated widely in human breast cancers. KAP1 silencing in breast cancer cells reduced proliferation and inhibited the growth and metastasis of tumor xenografts. Conversely, KAP1 overexpression stimulated cell proliferation and tumor growth. In cells where KAP1 was silenced, we identified multiple downregulated genes linked to tumor progression and metastasis, including EREG/epiregulin, PTGS2/COX2, MMP1, MMP2, and CD44, along with downregulation of multiple KRAB-ZNF proteins. KAP1-dependent stabilization of KRAB-ZNF required direct interactions with KAP1. Together, our results show that KAP1-mediated stimulation of multiple KRAB-ZNF contributes to the growth and metastasis of breast cancer.
GLP-1 secretion by microglial cells and decreased CNS expression in obesity (2012)

The findings that microglial mRNA expression of proglucagon and GLP-1 protein expression are affected by high levels of free fatty acids and that both mRNA expression levels of proglucagon and secretion levels of GLP-1 are affected by inflammatory stimuli could be of pathogenic importance for the premature neurodegeneration and cognitive decline commonly seen in T2D patients, and they may also be harnessed to advantage in therapeutic efforts to prevent or treat such disorders.
Randomized clinical trials (2009)

Abstract Randomization is widely recognized as a fundamental principle in the design of Phase III clinical trials. It is a way to minimize conscious and unconscious bias among patients and physicians with regard to treatment assignment and treatment acceptability. This paper outlines the advantages and disadvantages of randomization in clinical trials with discussions in permuted blocks, stratified randomization, cluster randomization, and the role of randomization as a basis for inference. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Applications of Computational Statistics > Clinical Trials
Use of a Capture-Based Pathogen Transcript Enrichment Strategy for RNA-Seq Analysis of the Francisella Tularensis LVS Transcriptome during Infection of Murine Macrophages (2013)

Francisella tularensis is a zoonotic intracellular pathogen that is capable of causing potentially fatal human infections. Like all successful bacterial pathogens, F. tularensis rapidly responds to changes in its environment during infection of host cells, and upon encountering different microenvironments within those cells. This ability to appropriately respond to the challenges of infection requires rapid and global shifts in gene expression patterns. In this study, we use a novel pathogen transcript enrichment strategy and whole transcriptome sequencing (RNA-Seq) to perform a detailed characterization of the rapid and global shifts in F. tularensis LVS gene expression during infection of murine macrophages. We performed differential gene expression analysis on all bacterial genes at two key stages of infection: phagosomal escape, and cytosolic replication. By comparing the F. tularensis transcriptome at these two stages of infection to that of the bacteria grown in culture, we were able to identify sets of genes that are differentially expressed over the course of infection. This analysis revealed the temporally dynamic expression of a number of known and putative transcriptional regulators and virulence factors, providing insight into their role during infection. In addition, we identified several F. tularensis genes that are significantly up-regulated during infection but had not been previously identified as virulence factors. These unknown genes may make attractive therapeutic or vaccine targets.
Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing. (1993)

A series of 152 human bladder tumors, 14 bladder tumor cell lines, and 1 immortal urothelial cell line were examined by single-strand conformation polymorphism (SSCP) and designed restriction fragment.length polymorphism analyses for mutations in exons 1 and 2 of the H-ras gene. Nine tumors (6%) contained mutations. There was complete concordance between SSCP and restriction fragment length polymorphism analyses. Six mutations in exon 1 and three in exon 2 were identified by SSCP analysis. Subsequent restriction fragment length polymorphism analysis showed that of the exon 1 mutations, four were in codon 12 and two in codon 13, and all three exon 2 mutations were in codon 61. Eight mutations were confirmed by direct sequencing. One codon 13 mutation could not be identified by direct sequencing. Distinct strand mobility shifts detected by SSCP analysis identified specific point mutations, and in all cases, strands containing different mutations migrated differently. The base substitutions identified in these bladder tumors were diverse and included four transversions (three G-->T and one A-->T) and four transitions (two G-->A and two A-->G). This pattern of base substitutions is compatible with interactions of the urothelium with more than one class of environmental agent during bladder tumor development. No correlation was found between tumor grade and/or stage and the presence of H-ras mutation. We conclude that H-ras mutation does not play a role in the development of the majority of transitional cell tumors of the bladder.
Theoretical analysis of feedback mechanisms of two-dimensional finite-sized photonic-crystal lasers (2005)

Theoretical investigations are carried out for close-to-lasing two-dimensional finite-sized photonic crystals with active (gain) lattice points. First, laser oscillations with lower thresholds are found to occur near the photonic band edges where optical gain is enormously intensified. For several modes isolated around the band edge, the field-intensity spectra in reciprocal space and the Poynting-vector distributions in real space are investigated in detail in close-to-lasing photonic crystals. By comparing the phenomena that occur in photonic crystals with a symmetric or an asymmetric outward form, this paper clarifies the differences in the feedback mechanisms of these crystals. In a symmetric photonic crystal, laser oscillation occurs through the waves propagating along the straight passages. This feedback is basically the same as that of ordinary one-dimensional lasers, although it exhibits a complicated behavior that light waves propagating in a variety of directions interfere with each other. In an asymmetric photonic crystal, laser oscillation occurs through the waves circulating within the crystal, which could be called recurrent-photon feedback. This feedback, however, can be construed as an extension of the feedback in ordinary one-dimensional distributed-feedback lasers.
Development tests on a 5-LBF bipropellant thruster using a platinum/rhodium thrust chamber (1998)

This paper describes the results from development tests on a new 5 Ibf thruster for satellite stationkeeping. The thruster was designed to provide steady-state propellant throughput capability beyond that of the current generation of silicide-coated columbium thrusters. This new thruster uses an uncoated thrust chamber made from a platinum/rhodium alloy and an injector specifically designed for use with this chamber to improve steadystate and pulse mode performance. To date the chamber has experienced 1627 Ibm of steady-state throughput with no evidence of degradation. The thruster has a nominal specific impulse (Isp) of 300s at 5 Ibf thrust at a nominal feed pressure of 220 psia. The thruster has been successfully tested over the mixture ratio range of 1.0-2.1, at feed pressures of 140-400 psia, and with propellant temperatures as high as 153F. Thermal stability has been demonstrated by conducting 4 hour burns, hot restart, and soakback tests. The thruster was designed with minimum propellant dribble volumes to improve pulse mode performance. Pulse mode tests have demonstrated improved specific impulse and pulseto-pulse repeatability with a standard deviation (!CT) of approximately 1% of the average impulse.
DNA–gadolinium–gold nanoparticles for in vivo T1 MR imaging of transplanted human neural stem cells (2015)

The unambiguous imaging of transplanted cells remains a major challenge to understand their biological function and therapeutic efficacy. In vivo imaging of implanted cells is reliant on tagging these to differentiate them from host tissue, such as the brain. We here characterize a gold nanoparticle conjugate that is functionalized with modified deoxythymidine oligonucleotides bearing Gd(III) chelates and a red fluorescent Cy3 moiety to visualize in vivo transplanted human neural stem cells. This DNA-Gd@Au nanoparticle (DNA-Gd@AuNP) exhibits an improved T1 relaxivity and excellent cell uptake. No significant effects of cell uptake have been found on essential cell functions. Although T1 relaxivity is attenuated within cells, it is sufficiently preserved to afford the in vivo detection of transplanted cells using an optimized voxel size. In vivo MR images were corroborated by a post-mortem histological verification of DNA-Gd@AuNPs in transplanted cells. With 70% of cells being correctly identified using the DNA-Gd-AuNPs indicates an overall reliable detection. Less than 1% of cells were false positive for DNA-Gd@AuNPs, but a significant number of 30% false negatives reveals a dramatic underestimation of transplanted cells using this approach. DNA-Gd@AuNPs therefore offer new opportunities to visualize transplanted cells unequivocally using T1 contrast and use cellular MRI as a tool to derive biologically relevant information that allows us to understand how the survival and location of implanted cells determines therapeutic efficacy.
Noise Limit in Heterodyne Interferometer Demodulator for FBG-Based Sensors (2004)

This paper reports the results of a recent investigation on the noise-limited performance in heterodyne interferometric demodulation systems for fiber Bragg grating strain sensors. Theoretical and simulation results are presented and compared with experimental results.
Advanced bipolar circuits-a perspective (2002)

Reviews the recent advances in high-speed low-power bipolar circuits. The basic underlying principles for achieving superior power-delay performance and load driving capability, such as charge-buffering, DC/AC coupled active pull-down schemes, and complementary push-pull approaches, are examined. The utilization and combination of these basic principles to form various high-speed low-power npn-only and complementary bipolar circuit configurations are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Switched bias proportional navigation for homing guidance against highly maneuvering targets (1994)

A new form of the Proportional Navigation (PN) guidance law for short-range homing missiles is proposed. Named the Switched Bias Proportional Navigation (SBPN) law, it is derived by invoking sliding-mode control theory and is structured around the basic PN, with an additive switched bias term. This additional term depends only on the polarity of the line-of-sight rate, which is readily available with a seeker. It is shown that the bias term acts as an estimate of the target acceleration and other unmodeled dynamics. An adaptive procedure is suggested to select the gain of this term, which results in improved performance. The SBPN is almost as simple to implement as the PN law itself, as it does not require any additional information related to the engagement, in the form of either measurements or estimates. Simulation results show that the acceleration profiles of SBPN closely follow those of augmented PN guidance law, after a short initial transient. They further demonstrate the robustness of the proposed SBPN in the presence of missile velocity variation.
Foaming of Poly(lactic acid) Using Supercritical Carbon Dioxide as Foaming Agent: Influence of Crystallinity and Spherulite Size on Cell Structure and Expansion Ratio (2014)

Using supercritical carbon dioxide (Sc-CO2) as physical foaming agent, foamed poly(lactic acid) (PLA) samples were prepared in a batch process via constant- and varying-temperature modes (CTM and VTM). Their crystallinity, cellular structure, and expansion ratio were investigated. In the CTM, the samples foamed at low saturation temperatures present three regions (skin, inner, and core regions). The uniformity of cellular structure is much improved with increasing saturation temperature. In the VTM, saturation temperature exerts a significant impact on the size of spherulites formed in gas saturation stage. Large spherulites evolve into entities surrounded by elongated cells or submicro-sized cells in interlamellar regions after foaming at 140 °C and into small cells (mean diameter of 0.6 μm) at 160 °C, whereas small spherulites generally evolve into stamen-like cell structure at 140 °C. Interestingly, uniform cellular structure with high expansion ratio (49.8) or bimodal cellular structure can be obtained by tuning saturation and foaming temperatures.
Enzyme promiscuity: using the dark side of enzyme specificity in white biotechnology (2014)

Abstract Enzyme promiscuity can be classified into substrate promiscuity, condition promiscuity and catalytic promiscuity. Enzyme promiscuity results in far larger ranges of organic compounds which can be obtained by biocatalysis. While early examples mostly involved use of lipases, more recent literature shows that catalytic promiscuity occurs more widely and many other classes of enzymes can be used to obtain diverse kinds of molecules. This is of immense relevance in the context of white biotechnology as enzyme catalysed reactions use greener conditions.
Iron deficiency of soybean in the North Central U.S. and associated soil properties (2004)

Abstract Despite extensive research and variety screening efforts, iron deficiency chlorosis is a common, yield-limiting condition for soybean [Glycine max (L.) Merr.] grown in areas with high pH, calcareous soils. In the North Central U.S., total land area where soybean is grown on high pH soils is approximately 1.8 million ha, with iron deficiency responsible for an estimated loss in soybean grain production of 340,000 Mg at a value of $820 million per annum. This is a significant increase in the extent of iron deficiency problems relative to the past because of an expansion of soybean production in the region. Soil properties associated with iron deficiency in this region compared to adjacent areas without iron deficiency include greater soil moisture content and concentrations of soluble salts, carbonates, and DTPA-Cr, and lesser concentrations of DTPA-Fe, Mn, Ni, and Cd. Iron deficiency occurs due to multiple stresses and not simply to limited available iron. Biotic and management factors such as pests and diseases, symbiotic nitrogen fixation, seeding rate, and herbicide application also interact with iron deficiency in the field. There is a need to better match varieties to the specific soil and environmental conditions to which they are adapted.
Talent Management in the Hospitality Sector: Predicting Discretionary Work Behaviour (2022)

Hospitality organisations have suffered a lot of setbacks, such as low performance caused by the COVID-19 pandemic, during which most management took drastic decisions to retrench talent, and these decisions have engendered low discretionary work behaviour and low emotional labour display amongst its talent. These maladies would have been averted if talent management practices were implemented effectively by hospitality organisations. It is based on this premise that this study investigates the effect of talent management on discretionary work behaviour in hospitality organisations in Nigeria using a survey research design. A sample frame of 820 was drawn from 60 registered hospitality organisations in the south-eastern part of Nigeria. A sample size of 263 was drawn from the sample frame. Linear regression was employed to analyse the formulated hypotheses with the aid of IBM statistical package for the social sciences version 20.0. The findings of the study show that talent management dimensions have significant effects on discretionary work behaviour in hospitality organisations in Nigeria. The study concludes that talent management measured in terms of talent attraction, talent development and talent retention have significant effects on the indicators of discretionary work behaviour. The study recommends that human resource professionals and organisational leaders should utilize talent management as a strategy to enhance discretionary work behaviour in their respective organisations.
Normalization of ultrasonic scattering measurements to obtain average differential scattering cross sections for tissues (1983)

An integral expression is derived for the normalization of ultrasonic scattering data to obtain an average differential scattering cross section per unit volume for tissue which is modeled as a random, fluidlike medium. The expression assumes narrowband signals and involves the incident beam, receiver beam pattern, and time gates. The beams and gates combine to form a window which limits the scattering volume. The derivation of the expression requires that the dimensions of the window be large compared to the correlation length of the scattering medium. Numerical values of the normalizing integral are given for cylindrical and beamlimited scattering volumes as a function of incident frequency and scattering angle under the assumptions of Gaussian beams and rectangular time gates. A set of curves is presented to relate the percent difference between the result for backscatter from a cylindrical scattering volume and from a beamlimited scattering volume which does not include the truncation effect of the cylinder boundary. Although similar in form to normalizations used by others, the integral in this paper is obtained from a derivation which treats physical parameters rigorously and provides a precise statement of conditions which are sufficient to obtain system-independent scattering data.
Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines (2006)

In HLA-incompatible hematopoietic stem cell transplantation, alloreactive donor T cells recognizing recipient mismatch HLA cause severe graft-versus-host disease (GVHD). Strategies allowing the selective depletion of alloreactive T cells as well as the enhancement of graft-versus-malignancy immunity would be beneficial. We generated donor CD8 T-cell lines in vitro using allogeneic recipient cells mismatched at a single HLA class I allele or haplotype as stimulators. Recipient cells were obtained from acute myeloid leukemias, renal-cell carcinomas, and CD40L-induced B lymphoblasts. Resulting alloreactive T cells were activated by incubating day 21 T-cell cultures with HLA-mismatch transfected K562 cells or recipient-derived fibroblasts. Selective allodepletion (SAD) was subsequently performed by a newly developed immunomagnetic depletion approach targeting the tumor necrosis factor receptor molecule CD137 (4-1BB). Compared with other activation-induced antigens, CD137 showed a superior performance based on a consistently low baseline expression and a rapid up-regulation following alloantigen stimulation. In 15 different SAD experiments, the frequency of alloreactive CD8 T cells was reduced to a median of 9.5% compared with undepleted control populations. The allodepleted T-cell subsets maintained significant antitumor and antiviral CD8 responses. In vitro expansion of tumor-reactive T cells followed by CD137-mediated SAD might enhance the antitumor efficacy of T-cell allografts with lower risk of inducing GVHD.
Preventing Infectious Disease in Sports (2003)

Preventing infectious disease in sports is fundamental to maintaining team effectiveness and helping individual athletes avoid the adverse effects of illness. Good general hygiene practices, immunization, efforts to minimize exposure to specific diseases, and certain prophylactic measures are essential. Teammates, coaches, athletic trainers, officials, and healthcare providers should actively participate in these preventive efforts, and community public health resources may be involved when appropriate. In addition to treating individual athletes, the team physician's role is to increase awareness, vigilance, and compliance with procedures to prevent the spread of disease.
Disseminated Necrotizing Myeloencephalitis: A Herpes-Associated Neurological Disease of Horses (1976)

Equine viral rhinopneumonitis type I virus was isolated from spinal cord and brain of a paraparetic horse with disseminated necrotizing myeloencephalitis. Necrotic arteriolitis, nonsuppurative necrotizing myeloencephalitis and Gasserian ganglioneuritis were present. On record were 12 more cases of horses with similar lesions. The horses had been ataxic or paretic for up to several weeks. A field survey indicated that 14 of 24 horses with acute myelitic signs developed them after recent exposure to respiratory disease.
Light‐Induced Conversion of an Insulating Refractory Oxide into a Persistent Electronic Conductor. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia (2015)

Olfactory impairment is associated with incident aMCI and progression from aMCI to AD dementia. These findings are consistent with previous studies that have reported associations of olfactory impairment with cognitive impairment in late life and suggest that olfactory tests have potential utility for screening for MCI and MCI that is likely to progress.