gebhart/patrepeval huggingface dataset:
Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients (1999)

To determine whether pretreatment and/or in-treatment serum uric acid (SUA) is independently and specifically associated with cardiovascular events in hypertensive patients, we examined the 20-year experience of 7978 mild-to-moderate hypertensive participants in a systematic worksite treatment program. Clinical evaluation and treatment were protocol-directed. SUA was measured at entry and annually thereafter. Subjects were stratified according to gender-specific quartile of baseline SUA. Blood pressures at entry and in-treatment were, respectively, 152.5/95.6 and 138.9/85.4 mm Hg. SUA was normally distributed with a mean of 0.399+/-0.0893 and 0. 321+/-0.0833 mmol/L for men and women, respectively. Subjects with highest SUA were heavier, had greater evidence of cardiovascular disease (CVD), higher systolic blood pressure, higher creatinine, more frequent diuretic use, and lower prevalence of diabetes. During an average follow-up of 6.6 years (52 751 patient-years), 548 CVD events (183 mortal) and 116 non-CVD events occurred. In bivariate analysis, the association of SUA to CVD was more robust in nonwhites than whites and in patients at low versus high CVD risk. In multivariate analysis, CVD incidence was significantly associated with SUA with a hazard ratio of 1.22 (95% confidence interval 1.11 to 1.35), controlling for other known cardiovascular risk factors, including serum creatinine, body mass index, and diuretic use. Despite blood pressure control, SUA levels increased during treatment and were significantly and directly associated with CVD events, independently of diuretic use and other cardiovascular risk factors.
On sampling rate, analog prefiltering, and sufficient statistics for digital receivers (1994)

We consider the joint sequence estimation, timing and phase recovery for linear modulation. The paper differs from the classical ones in the sense that time-discrete algorithms suitable for fully digital receivers are discussed. Sufficient conditions are given such that the signal samples represent sufficient statistics. These conditions involve signal bandwidth, sampling/symbol rate and the analog prefilter characteristics. It is shown that the sampling rate need not be an exact multiple of the symbol rate, i.e., the samples can be taken from a free-running oscillator. All subsequent signal processing operations in the receiver then operate with the clock of this free-running oscillator. Timing recovery is then performed by a time-variant linear digital interpolator and a decimator. Carrier recovery and sequence estimation are performed at an average rate of one symbol per sample. The digital matched filter for this case is derived for an arbitrary colored noise spectrum.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Simultaneous Seismic Inversion (2004)

P165 SIMULTANEOUS SEISMIC INVERSION Introduction 1 The usefulness of seismic AVO attributes increased dramatically when elastic inversion of partial stacks was introduced. Utilizing the mathematical concept of elastic impedance the technology from the inversion of full stack data for acoustic impedance could be transferred to partial stacks. Each partial stack was inverted for elastic impedance and the elastic impedance results were combined to estimates of physical properties like acoustic impedance shear impedance and Vp/Vs. This type of AVO inversion has however some serious drawbacks that recent developments in simultaneous inversion have overcome. This new simultaneous inversion method is based on
p53 Inhibitor Pifithrin α Can Suppress Heat Shock and Glucocorticoid Signaling Pathways (2003)

Pifithrin alpha (PFTalpha) is a chemical compound isolated for its ability to suppress p53-mediated transactivation. It can protect cells from p53-mediated apoptosis induced by various stimuli and reduce sensitivity of mice to gamma radiation. Identification of molecular targets of PFTalpha is likely to provide new insights into mechanisms of regulation of p53 pathway and is important for predicting potential risks associated with administration of PFTalpha-like p53 inhibitors in vivo. We found that PFTalpha, in addition to p53, can suppress heat shock and glucocorticoid receptor signaling but has no effect on nuclear factor-kappaB signaling. PFTalpha reduces activation of heat shock transcription factor (HSF1) and increases cell sensitivity to heat. Moreover, it reduces activation of glucocorticoid receptor and rescues mouse thymocytes in vitro and in vivo from apoptotic death after dexamethasone treatment. PFTalpha affected both signaling pathways in a p53-independent manner. These observations suggest that PFTalpha targets some unknown factor that is common for three major signal transduction pathways.
Carcinoembryonic antigen, alphafetoprotein and alpha and beta subunits of human chorionic gonadotropin in plasma of children with acute leukaemia. (1987)

The plasma carcinoembryonic antigen, alpha-fetoprotein and the alpha and beta subunits of human chorionic gonadotropin levels were measured by radioimmunoassay in 44 children with acute leukaemia. These markers were determined repeatedly every 3 months at different stages of the disease (at onset, in complete remission, during bone marrow and extramedullary relapse). Elevated CEA levels were present in 64% of children at the onset of acute leukaemia and during bone marrow relapse. Elevated CEA levels decreased during induction treatment and they became normal with attainment of complete remission. In 7/12 patients who developed bone marrow relapse elevated CEA levels and in 4 of them raised levels appeared 3-4 months before there had been any other evidence of relapse. In 6/13 patients with extramedullary relapse, elevated CEA levels were found. AFP, alpha and beta hCG values in different stages of the disease were elevated sporadically; they did not reflect the activity of leukaemia.
Integration of passive seismic and 3D reflection seismic in an unconventional shale gas play: relationship between rock fabric and seismic moment of microseismic events (2012)

Reservoir and completion quality are key parameters defining shale reservoirs. This study addresses completion quality by investigating the interaction between preexisting faults (rock fabric) and microseismic response of three multi-stage hydraulic stimulations. A new approach is presented to integrate rock fabric derived from 3D reflection seismic with microseismic information from hydraulic fracture monitoring. It is shown that regions of high degree of rock fabric correlate with microseismic events with a high seismic moment and a low P/SH ratio. In areas with a high degree of rock fabric fracture complexity increases as a result of changing rock properties and/or perturbations of in-situ stresses.
Analysis-by-synthesis feature estimation for robust automatic speech recognition using spectral masks (2014)

Spectral masking is a promising method for noise suppression in which regions of the spectrogram that are dominated by noise are attenuated while regions dominated by speech are preserved. It is not clear, however, how best to combine spectral masking with the non-linear processing necessary to compute automatic speech recognition features. We propose an analysis-by-synthesis approach to automatic speech recognition, which, given a spectral mask, poses the estimation of mel frequency cepstral coefficients (MFCCs) of the clean speech as an optimization problem. MFCCs are found that minimize a combination of the distance from the resynthesized clean power spectrum to the regions of the noisy spectrum selected by the mask and the negative log likelihood under an unmodified large vocabulary continuous speech recognizer. In evaluations on the Aurora4 noisy speech recognition task with both ideal and estimated masks, analysis-by-synthesis decreases both word error rates and distances to clean speech as compared to traditional approaches.
Facial Recognition Using Tensor-Tensor Decompositions (2013)

A tensor is a multidimensional array. First-order tensors and second-order tensors can be viewed as vectors and matrices, respectively. Tensors of higher order, with the ability to include more information, appear more frequently nowadays in image and signal processing, data mining, biomedical engineering, and so on. With the recent work of Kilmer and Martin, familiar matrix-based factorizations in linear algebra can be extended in a straightforward way to third-order tensors based on their new tensor multiplication and concepts. Our method has an advantage over a popular tensor-based face recognition algorithm called TensorFaces, which is based on the higher-order SVD of an arrangement of the images in a database, in that it does not require a least squares solve for the coefficients. In this paper, we give a brief introduction to the new tensor framework and apply the induced tensor decompositions to the application of facial recognition. In the numerical results, we compare our new approaches with the traditional principal component analysis method based on matrix decomposition (also known as eigenfaces) and with TensorFaces.
Welding of polymer interfaces (1989)

Abstract Studies of strength development at polymer‐polymer interfaces are examined and applications to welding of similar and dissimilar polymers are considered. The fracture properties of the weld, namely, fracture stress, σ, fracture energy, G Ic , fatigue crack propagation rate da / dN , and microscopic aspects of the deformation process are determined using compact tension, wedge cleavage, and double cantilever beam healing experiments. The mechanical properties are related to the structure of the interface via microscopic deformation mechanisms involving disentanglement and bond rupture. The time dependent structure of the welding interface is determined in terms of the molecular dynamics of the polymer chains, the chemical compatibility, and the fractal nature of diffuse interfaces. Several experimental methods are used to probe the weld structure and compare with theoretical scaling laws, Results are given for symmetric amorphous welds, incompatible and compatible asymmetric amorphous welds, incompatible semicrystalline and polymer‐metal welds. The relevance of interface healing studies to thermal, friction, solvent and ultrasonic welds is discussed.
[Cerebral blood flow in syndrome of vertebral artery]. (2000)

The paper presents the results of clinical-neurologic study of the indices of cerebral hemodynamics (ultrasonic dopplerography of major arteries of the head, transcranial dopplerography) in 114 patients aged 15-36 years with vertebral artery (VA) syndrome. In the clinical status both subjective manifestations and typical vertebral symptomatology prevailed. There were tendencies to changes of blood flow in extracranial arteries of the carotid system that differed in compression-irritative and reflex-angiospastic forms of VA syndrome. The most significant changes (decrease of blood flow velocity, increase of the indices of the kinematics of blood flow) were observed in vertebral and posterior cerebral arteries (PCA), especially in compression-irritative form of VA syndrome. Homolateral decrease of blood flow in PCA was characteristic for unilateral decrease of blood flow in VA. The results show an important role of the changes of cerebral hemodynamics in pathogenesis of the syndrome of VA.
Anterior uveitis and multiple sclerosis (1989)

Three patients with clinically definite multiple sclerosis and uveitis were studied. The uveitis presented as inflammation of the anterior segment of the eye (iridocyclitis) and was characterized by large keratic precipitates and posterior synechiae, consistent with a granulomatous iridocyclitis. Clinical and laboratory evidence militated against other central nervous system diseases often associated with uveitis including neurosarcoidosis, Behçet's syndrome, Vogt-Koyanagi-Harada disease, neurosyphilis, and tuberculosis. Further attention should be directed to the possibility of granulomatous anterior uveitis in patients with multiple sclerosis.
A method for extracting plant roots from soil which facilitates rapid sample processing without compromising measurement accuracy (2007)

This study evaluates a novel method for extracting roots from soil samples and applies it to estimate standing crop root mass (+/- confidence intervals) in an eastern Amazon rainforest. Roots were manually extracted from soil cores over a period of 40 min, which was split into 10 min time intervals. The pattern of cumulative extraction over time was used to predict root extraction beyond 40 min. A maximum-likelihood approach was used to calculate confidence intervals. The temporal prediction method added 21-32% to initial estimates of standing crop root mass. According to predictions, complete manual root extraction from 18 samples would have taken c. 239 h, compared with 12 h using the prediction method. Uncertainties (percentage difference between mean, and 10th and 90th percentiles) introduced by the prediction method were small (12-15%), compared with uncertainties caused by spatial variation in root mass (72-191%, for nine samples per plot surveyed). This method provides a way of increasing the number of root samples processed per unit time, without compromising measurement accuracy.
Instantaneous Direction of Arrival Measurements in Mobile Radio Channels Using Virtual Circular Array Antennas (2016)

Two methods for the estimation of direction of arrival in mobile radio channels by means of a virtual uniform circular array are presented and experimentally validated. The methods rely on the MUSIC algorithm and can be applied for measurements in the mm-wave bands (6-100GHz) as required for future 5G systems. They are capable of measurement cycles of up to 100 Hz which are very short in comparison of state-of- the-art approaches. Thus the approaches are suitable to collect a high number of channel realizations even in time-variant outdoor environments. With respect to the verification measurements at 28GHz, a modular instrument based measurement setup is introduced.
Efficiency and Side Effects of Intracavernous Injections of Moxisylyte in Impotent Patients: A Dose-Finding Study Versus Placebo (1993)

We assessed the efficiency and tolerance of the alpha-blocking agent moxisylyte in 2 double-blind studies versus placebo performed in 12 neurogenic patients with spinal cord lesions and in 61 patients presenting with either psychogenic impotence (30) or erectile dysfunction that was predominantly neither psychogenic, hormonal nor neurogenic (31). In each etiological group patients were randomized (according to latin square method) to receive 3 single doses (10, 20 and 30 mg.) of moxisylyte and a placebo. The erectile response was determined 5, 10, 15, 20 and 30 minutes after each injection. Whatever etiology of impotence and dosage tested, the erectile response induced by moxisylyte was significantly higher than the placebo-induced response. No difference occurred among the 3 doses. In 93% of the patients moxisylyte induced an erectile response, including tumescence in 6, partial rigidity in 16 and complete rigidity in 46. Thus, in 62 of 73 patients (85%) the drug allowed initiation of erection adequate for intercourse. Placebo induced such erection in only 25% of the cases and in 55% there was no response. Tolerance was good and no priapism occurred. Only 4 patients (5%) reported mild pain during injection but erections were never painful, 1 presented with moderate and transient hypotension at the 20 mg. dose and a painless prolonged erection was observed in 1 case after the lowest dose. Drugs such as moxisylyte should be given before less well tolerated drugs.
ECNU: Extracting Effective Features from Multiple Sequential Sentences for Target-dependent Sentiment Analysis in Reviews (2015)

This paper describes our systems submitted to the target-dependent sentiment polarity classification subtask in aspect based sentiment analysis (ABSA) task (i.e., Task 12) in SemEval 2015. To settle this problem, we extracted several effective features from three sequential sentences, including sentiment lexicon, linguistic and domain specific features. Then we employed these features to construct classifiers using supervised classification algorithm. In laptop domain, our systems ranked 2nd out of 6 constrained submissions and 2nd out of 7 unconstrained submissions. In restaurant domain, the rankings are 5th out of 6 and 2nd out of 8 respectively.
Kinetic and structural investigations of [Fe<sup>III</sup>(edta)]–[edta = ethylenediaminetetra-acetate(4–)] catalysed decomposition of hydrogen peroxide (1985)

A detailed kinetic analysis is given of hydrogen peroxide decomposition catalysed by [FeIII(edta)]–[edta = ethylenediaminetetra-acetate(4–)]. Structural investigations have been made using n.m.r. And electronic absorption spectroscopy. It is demonstrated that the monohydroxy complex, [Fe(edta)(OH)]2–, is the primary active catalyst and this reacts with the hydrogenperoxide ion to produce the well known purple complex [Fe(edta)(OH)(HO2)]3–. Decomposition of hydrogen peroxide conforms to Michaelis–Menten kinetics, the rate-determining step involving breakdown of this complex. In contrast to earlier reports, it is shown that the HO2– ion displaces a carboxy-group from [Fe(edta)(OH)]2– rather than the hydroxy group. The dihydroxy complex [Fe(edta)(OH)2]3– is also shown to form a purple peroxy-complex with HO2–, but its breakdown occurs at a much slower rate. The results are consistent with formation of radicals upon breakdown of the peroxy-complex and in subsequent reactions.
Validation Study for PathogenDx EnviroX-F Assay for the Detection of Listeria, L. monocytogenes, and Salmonella in Environmental Surface Samples: AOAC <i>Performance Tested Method</i>SM 092001 (2022)

Abstract Background The PathogenDx EnviroX-F uses microarray technology to simultaneously detect Listeria species, Listeria monocytogenes, and Salmonella species from environmental samples without the need for enrichment. Objective The validation study included a matrix study of four matrices (stainless steel, plastic, rubber, and sealed concrete) comparing the PathogenDx EnviroX-F assay to the US Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) Chapter 10, “Detection of L. monocytogenes in Foods and Environmental Samples, and Enumeration of L. monocytogenes in Foods” (revised March 2017), and FDA BAM Chapter 5,“Salmonella” (revised February 2020). Other required Performance Tested MethodSM parameters evaluated included: inclusivity and exclusivity, robustness, instrument variation, and product consistency and stability. Methods The PathogenDx EnviroX-F assay was evaluated with 30 unpaired replicate surface areas for each environmental surface. The candidate method was evaluated without an enrichment step. Results In the inclusivity and exclusivity study 50 out of 50 Listeria isolates were detected, 50 out of 50 L. monocytogenes strains were detected, 108 out of 108 Salmonella strains were detected, and 95 out of 95 exclusivity strains were correctly excluded. In the matrix study, the PathogenDx EnviroX-F assay showed no significant differences between confirmed results or between candidate and reference method results for 4” × 4” environmental surface areas for each matrix. Conclusion The PathogenDx EnviroX-F assay is an effective method for the qualitative detection of Listeria spp., L. monocytogenes, and Salmonella spp. from environmental surface swabs. Highlights The PathogenDx EnviroX-F assay will be the first PTM-approved multiplex assay for Listeria spp., L. monocytogenes, and Salmonella without the need for an environment step.
RETracer (2016)

Many software providers operate crash reporting services to automatically collect crashes from millions of customers and file bug reports. Precisely triaging crashes is necessary and important for software providers because the millions of crashes that may be reported every day are critical in identifying high impact bugs. However, the triaging accuracy of existing systems is limited, as they rely only on the syntactic information of the stack trace at the moment of a crash without analyzing program semantics.
Single Ion Conduction in Lithium Methoxy Oligo(Oxyethylene) Sulfate-Comblike Polyether Complex (1993)

Abstract Two kinds of lithium methoxy oligo(oxyethylene) sulfate (LiSAEO8 and LiSAEO12) were synthesized, and their complexes were prepared with poly[methoxy oligo(oxyethylene) methacrylate-co-acrylamide] [P(MEO16-AM)]. Both the crystallinity and the glass transition temperature of the complexes decrease with increasing salt concentration. P(MEO16-AM)/LiSAEO8 and P(MEO16-AM)/LiSAEO12 exhibit single ion conduction characteristics, and their ionic conductivities at 25°C are 1.4 × 10−5 and 7.7 × 10−6 S/cm, respectively.
Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, Crotalus atrox (2020)

Snakebite envenomation causes over 140,000 deaths every year, predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases. It is associated with incredibly complex pathophysiology due to the vast number of unique toxins/proteins present in the venoms of diverse snake species found worldwide. Here, we report the purification and functional characteristics of a Group I (PI) metalloprotease (CAMP-2) from the venom of the western diamondback rattlesnake, <i>Crotalus atrox</i>. Its sensitivity to matrix metalloprotease inhibitors (batimastat and marimastat) was established using specific in vitro experiments and in silico molecular docking analysis. CAMP-2 shows high sequence homology to atroxase from the venom of <i>Crotalus atrox</i> and exhibits collagenolytic, fibrinogenolytic and mild haemolytic activities. It exerts a mild inhibitory effect on agonist-induced platelet aggregation in the absence of plasma proteins. Its collagenolytic activity is completely inhibited by batimastat and marimastat. Zinc chloride also inhibits the collagenolytic activity of CAMP-2 by around 75% at 50 μM, while it is partially potentiated by calcium chloride. Molecular docking studies have demonstrated that batimastat and marimastat are able to bind strongly to the active site residues of CAMP-2. This study demonstrates the impact of matrix metalloprotease inhibitors in the modulation of a purified, Group I metalloprotease activities in comparison to the whole venom. By improving our understanding of snake venom metalloproteases and their sensitivity to small molecule inhibitors, we can begin to develop novel and improved treatment strategies for snakebites.