gebhart/patrepeval huggingface dataset:
Patterning monolayer graphene with zigzag edges on hexagonal boron nitride by anisotropic etching (2016)

Graphene nanostructures are potential building blocks for nanoelectronic and spintronic devices. However, the production of monolayer graphene nanostructures with well-defined zigzag edges remains a challenge. In this paper, we report the patterning of monolayer graphene nanostructures with zigzag edges on hexagonal boron nitride (h-BN) substrates by an anisotropic etching technique. We found that hydrogen plasma etching of monolayer graphene on h-BN is highly anisotropic due to the inert and ultra-flat nature of the h-BN surface, resulting in zigzag edge formation. The as-fabricated zigzag-edged monolayer graphene nanoribbons (Z-GNRs) with widths below 30 nm show high carrier mobility and width-dependent energy gaps at liquid helium temperature. These high quality Z-GNRs are thus ideal structures for exploring their valleytronic or spintronic properties.
De Novo Synthesis of Racemic Altronolactam and Arabinonolactam Azasugars (1996)

Starting from the known peracetylated piperidinose derivatives (7a) and (7b), the corresponding altrono-and arabinone lactams (4) and ( 5) were obtained in a straightforward way.A selective two-step hydrolysis of the anomeric acetoxy groups gave the free hydroxyls (8a) and (8b) which were oxidised to the 5-lactams (9a) and (gb), respectively.Deprotection of these latter compounds led to the target molecules.Introduction.-The enzymatic glycosidase mechanism of pyranosic polysaccharides is believed to involve a transient type A half-chair oxocarbonium ion, which is stabilized by a complementary carboxylate anion of an active site catalytic residue.*.Z Structural azaanalogues of these glycosyl cations represent an attractive synthetic target for the design of potent glycoprocessing inhibit0rs.3~4GLactam azasugars like D-mannonolactam (1) and its Drhamnose analogue (2), once protonated in the active site of the appropriate enzyme, should meet the conformational and electrostatic requirements as potential glycosidase inhibitors.5And indeed they do, since both 1 and 2 are better inhibitors of a-mannosidase than DMJ (3), 1 being more powerful than the corresponding 6-deoxy compound (2) (Scheme 1).One may
Calcite Wettability in the Presence of Dissolved Mg<sup>2+</sup> and SO<sub>4</sub><sup>2–</sup> (2016)

The wettability of mineral surfaces controls a range of phenomena in natural and industrial processes. In reservoirs, rock wettability determines the effectiveness of oil production; thus, modification of mineral surface properties can lead to enhanced oil recovery. Recent work reports that potential determining ions in seawater, Mg2+, Ca2+, and SO42–, are responsible for altering the wettability of calcite surfaces. In favorable conditions, e.g., elevated temperature, calcium at the calcite surface can be replaced by magnesium, making organic molecules bind more weakly and water molecules bind more strongly, rendering the surface more hydrophilic. We used atomic force microscopy in chemical force mapping mode to probe the adhesion forces between a hydrophobic CH3-terminated AFM tip and a freshly cleaved calcite {10.4} surface to investigate wettability change in the presence of Mg2+ and SO42– at 75 and 80 °C. We made submicrometer scale maps of adhesion force and contact angle and demonstrated that the adhesion force between the hydrophobic tip and calcite decreases when both Mg and SO4 are present. Surface analysis with X-ray photoelectron spectroscopy showed Mg associated with calcite even after rinsing with CaCO3-saturated deionized water, suggesting sorption on or in calcite. When the calcite-saturated solution of MgSO4 was replaced by calcite-saturated NaCl at the same ionic strength, adhesion force increased again, indicating that the effect is reversible and suggesting Mg replacement by Ca. Experiments with solutions of Na2SO4 and MgCl2 suggest that Mg2+ uptake is favored when SO42– is also present.
[Differential regulation of phenazine-1-carboxylic acid and pyoluteorin production mediated by inactivated gacA in Pseudomonas sp. M18]. (2004)

Pseudomonas sp. M18 is one of the plant-growth-promoting rhizobacteria, which can produce fungicides: phenazine-1-carboxylic acid (PCA) and pyoluteorin (Plt). The chromosomally gacA inactivated mutant named M18G was constructed and its PCA production was enhanced 31-fold and Plt production was almost blocked completely in KMB medium. To assess the mutual influence of two antibiotics, the plt gene cluster mutant M18T and the phz gene cluster mutant M18GA were then constructed. Non-Plt-producing M18T could synthesize the same amount of PCA as wild type strain. Plt could not be detected in M18GA while PCA production was inhibited dramatically in it. Results indicate that promotion of PCA and inhibition of Plt production in M18G do result from the inactivation of gacA gene. It suggests that the production of antibiotics in strain M18 is differentially mediated by the gacA.
A Polymorphism Cluster at the 2q12 locus May Predict Response to Piromelatine in Patients with Mild Alzheimer's Disease (2021)

The 2q12 (2:107,510,000-107,540,000) 5-6 SNPs cluster may predict efficacy of piromelatine for mild AD. These findings warrant further investigation in a larger, prospective early-stage AD clinical trial for patients who are non-carriers of the 2q12 polymorphism cluster.
Nitrile Pathway Involving Acyl-CoA Synthetase (2005)

Two open reading frames (nhpS and acsA) were identified immediately downstream of the previously described Pseudomonas chlororaphis B23 nitrile hydratase (NHase) gene cluster (encoding aldoxime dehydratase, amidase, the two NHase subunits, and an uncharacterized protein). The amino acid sequence deduced from acsA shows similarity to that of acyl-CoA synthetase (AcsA). The acsA gene product expressed in Escherichia coli showed acyl-CoA synthetase activity toward butyric acid and CoA as substrates, with butyryl-CoA being synthesized. From the E. coli transformant, AcsA was purified to homogeneity and characterized. The quality of the recombinant protein was verified by the NH2-terminal amino acid sequence and the results of matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The apparent Km values for butyric acid, CoA, and ATP were 0.32 +/- 0.04, 0.37 +/- 0.02, and 0.22 +/- 0.02 mm, respectively. AcsA was shown to be a short-chain acyl-CoA synthetase, according to the catalytic efficiencies (kcat/Km) for various acids. The substrate specificity of AcsA was similar to those of aldoxime dehydratase, NHase, and amidase, the genes of which coexist in the same orientation in the gene cluster. P. chlororaphis B23 grew when cultured in a medium containing butyraldoxime as the sole carbon and nitrogen source. The activities of aldoxime dehydratase, NHase, and amidase were detected together with that of acyl-CoA synthetase under the culture conditions used. Moreover, on culture in a medium containing butyric acid as the sole carbon source, acyl-CoA synthetase activity was also detected. Together with the adjacent locations of the aldoxime dehydratase, NHase, amidase, and acyl-CoA synthetase genes, these findings suggest that the four enzymes are sequentially correlated with one another in vivo to utilize butyraldoxime as a carbon and nitrogen source. This is the first report of an overall "nitrile pathway" (aldoxime-->nitrile-->amide-->acid-->acyl-CoA) comprising these enzymes.
Text S1 - Molecular Predictors of 3D Morphogenesis by Breast Cancer Cell Lines in 3D Culture (2015)

<p>This file contains supplementary materials. Section 1 shows how pure thresholding fails in delineating foreground and background. Section 2 provides a summary of Zernike polynomial for representing morphometric traits. Section 3 summarizes background on non-linear regression methods for identifying molecular targets. Section 4 provides comparative analysis with the Gene Set Enrichment Analysis (GSEA). Section 5 outlines the details of validation protocol that includes quantitative image analysis.</p> <p>(0.78 MB PDF)</p>
Motion frozen 18F-FDG cardiac PET (2010)

PET reconstruction incorporating spatially variant 3D Point Spread Function (PSF) improves contrast and image resolution. “Cardiac Motion Frozen” (CMF) processing eliminates the influence of cardiac motion in static summed images. We have evaluated the combined use of CMF- and PSF-based reconstruction for high-resolution cardiac PET. Static and 16-bin ECG-gated images of 20 patients referred for 18F-FDG myocardial viability scans were obtained on a Siemens Biograph-64. CMF was applied to the gated images reconstructed with PSF. Myocardium to blood contrast, maximum left ventricle (LV) counts to defect contrast, contrast-to-noise (CNR) and wall thickness with standard reconstruction (2D-AWOSEM), PSF, ED-gated PSF, and CMF-PSF were compared. The measured wall thickness was 18.9 ± 5.2 mm for 2D-AWOSEM, 16.6 ± 4.5 mm for PSF, and 13.8 ± 3.9 mm for CMF-PSF reconstructed images (all P < .05). The CMF-PSF myocardium to blood and maximum LV counts to defect contrasts (5.7 ± 2.7, 10.0 ± 5.7) were higher than for 2D-AWOSEM (3.5 ± 1.4, 6.5 ± 3.1) and for PSF (3.9 ± 1.7, 7.7 ± 3.7) (CMF vs all other, P < .05). The CNR for CMF-PSF (26.3 ± 17.5) was comparable to PSF (29.1 ± 18.3), but higher than for ED-gated dataset (13.7 ± 8.8, P < .05). Combined CMF-PSF reconstruction increased myocardium to blood contrast, maximum LV counts to defect contrast and maintained equivalent noise when compared to static summed 2D-AWOSEM and PSF reconstruction.
ANALISIS PERMINTAAN RUMAH SEWA DI KOTA BANDA ACEH (2017)

This research aims to determine the factors that influence the demand for rental housing in the city of Banda Aceh. This study uses primary data by interview using a questionnaire. The sample used in this study were 60 respondents determination of the samples was determined using the descriptive method of correlation. Model analysis using Ordinary Least Square. The results show that the expenditure factor, price, accessibility and comfort positive effect on demand for rental homes in the city of Banda Aceh. Based on this research patrol officers should patrolling security routine in a location that there are many rental homes and homeowners can improve the facility rental house. Penelititian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi permintaan rumah sewa di Kota Banda Aceh.Penelitian ini menggunakan data primer dengan metode wawancara menggunakan kuesioner.Sampel yang digunakan dalam penelitian ini sebanyak 60 responden penentuan sampel ditentuka dengan menggnkan metode deskriptif korelasi . Model analisis menggunakan Ordinary Least Square. Hasil menunjukkan bahwa faktor pengeluaran, harga, aksesibilitas dan kenyamanan berpengaruh positif terhadap permintaan rumah sewa di Kota Banda Aceh.Berdasarkan penelitian ini sebaiknya petugas patroli keamanan berpatroli rutin di lokasi yang banyak terdapat rumah sewa dan pemilik rumah dapat meningkatkan fasilitas rumah sewa.
Neural Networks in Feedback Control Systems (2005)

This chapter contains sections titled: Introduction Background Feedback Linearization Design of Nn Tracking Controllers Nn Control for Discrete-time Systems Multiloop Nn Feedback Control Structures Feedforward Control Structures for Actuator Compensation Nn Observers for Output Feedback Control Reinforcement Learning Control Using Nns Optimal Control Using Nns Approximate Dynamic Programming and Adaptive Critics Historical Development, Referenced Work, and Further Study References Bibliography
A CMOS Dual-<italic>RC</italic> Frequency Reference With ±200-ppm Inaccuracy From −45 °C to 85 °C (2018)

This paper presents a 7-MHz CMOS RC frequency reference. It consists of a frequency-locked loop in which the output frequency of a digitally controlled oscillator (DCO) is locked to the combined phase shifts of two independent RC (Wien bridge) filters, each employing resistors with complementary temperature coefficients. The filters are driven by the DCO's output frequency and the resulting phase shifts are digitized by high-resolution phase-to-digital converters. Their outputs are then combined in the digital domain to realize a temperature-independent frequency error signal. This digitally assisted temperature compensation scheme achieves an inaccuracy of ±200 ppm from -45 °C to 85 °C after a two-point trim. The frequency reference draws 430 μA from a 1.8-V supply, while achieving a supply sensitivity of 0.18%/V and a 330-ppb Allan deviation floor in 3 s of measurement time.
HelexKids: A word frequency database for Greek and Cypriot primary school children (2016)

In this article, we introduce HelexKids, an online written-word database for Greek-speaking children in primary education (Grades 1 to 6). The database is organized on a grade-by-grade basis, and on a cumulative basis by combining Grade 1 with Grades 2 to 6. It provides values for Zipf, frequency per million, dispersion, estimated word frequency per million, standard word frequency, contextual diversity, orthographic Levenshtein distance, and lemma frequency. These values are derived from 116 textbooks used in primary education in Greece and Cyprus, producing a total of 68,692 different word types. HelexKids was developed to assist researchers in studying language development, educators in selecting age-appropriate items for teaching, as well as writers and authors of educational books for Greek/Cypriot children. The database is open access and can be searched online at www.helexkids.org .
Synthesis of Biologically Active Indenoisoquinoline Derivatives via a One-Pot Copper(II)-Catalyzed Tandem Reaction (2017)

A concise route for the synthesis of indenoisoquinoline derivatives from 2-iodobenzamide and 1,3-indanedione derivatives in the presence of copper(II) chloride and cesium carbonate in acetonitrile solvent is reported. A wide variety of 2-iodobenzamide derivatives and indandiones could be used to synthesize indenoisoquinoline derivatives and other fused indenoisoquinoline in moderate to good yields. This methodology was adapted for the one-step synthesis of a series of clinically active topoisomerase I inhibitors such as NSC 314622, LMP-400, LMP-776.
Comparative kinetic analysis of ammonium and nitrate acquisition by tropical lowland rice: implications for rice cultivation and yield potential (2000)

Nitrogen limitation compromises the realization of yield potential in cereals more than any other single factor. In rice, the world's most important crop species, the assumption has long been that only ammonium-N is efficiently utilized. Consequently, nitrate utilization has been largely ignored, although fragmentary data have suggested that growth could be substantial on nitrate. Using the short-lived radiotracer <sup>13</sup> N, we here provide direct comparisons of root transmembrane fluxes and cytoplasmic pool sizes for nitrate- and ammonium-N in a major variety of Indica rice (Oryza sativa), and show that nitrate acquisition is not only of high capacity and efficiency but is superior to that of ammonium. We believe our results have implications for rice breeding and molecular genetics as well as the design of water-management and fertilization regimes. Potential strategies to harness this hitherto unexplored N-utilization potential are proposed.
Role of Ferritin in the Control of the Labile Iron Pool in Murine Erythroleukemia Cells (1998)

In vitro studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits (H-Ft) and a nucleation center associated with ferritin L subunits (L-Ft). To assess the role played by the ferritin subunits in regulating intracellular iron distribution, we transfected mouse erythroleukemia cells with the H-Ft subunit gene mutated in the iron-responsive element. Stable transfectants displayed high H-Ft levels and reduced endogenous L-Ft levels, resulting in a marked change in the H:L subunit ratio from 1:1 in control cells to as high as 20:1 in some transfected clones. The effects of H-Ft overexpression on the labile iron pool were determined in intact cells by a novel method based on the fluorescent metallosensor calcein. H-Ft overexpression resulted in a significant reduction in the iron pool, from 1.3 microM in control cells to 0.56 microM in H-Ft transfectants, and in higher buffering capacity following iron loads. A fraction of the H-Ft-associated iron was labile, available to cell-permeant, but not cell-impermeant, chelators. The results of this study provide the first in vivo direct demonstration of the capacity of H-Ft to sequester cell iron and to regulate the levels of the labile iron pool.
A feature preserved mesh simplification algorithm (2011)

Large-volume mesh model faces challenge in rendering, storing, and transmission due to large size of polygon data. Mesh simplification is one of solutions to reduce the data size.This paper presents a mesh simplification method based on feature extraction withcurvature estimation to triangle mesh. The simplified topology preserves good geometricalfeatures in the area with distinct features, that is, coarse simplified mesh in the flat region and fine simplified mesh around the areas of crease and corner. Sequence of mesh simplification is controlled on the basis of geometrical feature sensitivity, which results inreasonable simplification topology with less data size. This algorithm can decrease thesize of the file by largely simplifying flat areas and preserving the geometric feature as well.

	 

	Key word: Mesh simplification, feature extraction, curvature estimation
Analysis and Mitigation of Low-Frequency Instabilities in Autonomous Medium-Voltage Converter-Based Microgrids With Dynamic Loads (2013)

The microgrid concept is gaining widespread acceptance in near-term future power networks. Medium-voltage (MV) microgrids can be subjected to a high penetration level of dynamic loads [e.g., induction motor (IM) loads]. The highly nonlinear IM dynamics that couple active power, reactive power, voltage, and supply frequency dynamics challenge the stability of MV droop-controlled microgrids. However, detailed analysis and, more importantly, stabilization of MV microgrids with IM loads, are not reported in current literature. To fill in this gap, this paper presents integrated modeling, analysis, and stabilization of MV droop-controlled microgrids with IM load. A detailed small-signal model of a typical MV droop-controlled microgrid system, which is based on the IEEE Standard 399, with both dynamic and static loads is developed. The proposed model accounts for the impact of supply frequency dynamics associated with the droop-control scheme to accurately link the microgrid frequency dynamics to the motor dynamics. To stabilize the microgrid system in the presence of IM loads, a 2-degree-of-freedom active damping controller is proposed to stabilize the newly introduced oscillatory dynamics. The proposed supplementary active damping controller does not interfere with the steady-state performance, and yields robust control performance under a wide range of droop parameters and robust damping performance at small- and large-signal disturbances. A theoretical analysis, simulation, and experimental results are presented to show the effectiveness of the proposed control scheme.
A Pseudo-Random Program Generator for Processor Functional Verification (2007)

This paper presents an ISA model-based pseudorandom program generator, called as VirgoASM, for functional verification of RISC3200 processor. The kernel parts of VirgoASM are instruction generating models and test templates. In order to ensure the complete instruction generating space and the legality and validity of generated single instruction, instruction opcode and operand sets are built according to the function, syntax format and semantic requirements of instructions. Then 17 instruction generating models are constructed based on the Cartesian product of instruction opcode and operand sets. According to instruction generating models and verification plans, various types of test templates are created to guarantee the quality requirement of generated instruction sequences. At last, we demonstrate that how to use VirgoASM to generate test programs.
A Randomized, Double-Blind, Placebo-Controlled Add-On Trial of Quetiapine in Outpatients With Bipolar Disorder and Alcohol Use Disorders (2008)

Quetiapine therapy was associated with a statistically significant decrease in depressive symptoms, but not alcohol use, in patients with bipolar disorder and alcohol dependence (p < .05).
Feasibility study of mobile phone WiFi detection in aerial search and rescue operations (2013)

In this paper, we show that it is feasible for a mobile phone to be used as an SOS beacon in an aerial search and rescue operation. We show with various experiments that we can reliably detect WiFi-enabled mobile phones from the air at distances up to 200 m. By using a custom mobile application that triggers WiFi scanning with the display off, we can simultaneously extend battery life and increase WiFi scanning frequency, compared to keeping the phone in the default scanning mode. Even if an application is not installed or used, our measurement study suggests that it may be possible to detect mobile devices from their background WiFi emissions alone.
Isolation of embryonal carcinoma cell lines that express integrated recombinant genes flanked by the Moloney murine leukemia virus long terminal repeat. (1985)

We have used a producer NIH 3T3 cell line that secretes, together with the helper Moloney murine leukemia virus (Mo-MuLV), a transducing recombinant virus containing the neomycin-resistance gene linked to the Mo-MuLV long terminal repeat (LTR). By infecting three embryonal carcinoma cell lines, PCC4.aza1R, F9tk-, and Nulli-SCC1, with this recombinant virus, we have isolated many transductant clones that stably express the integrated neomycin-resistance gene. These clonal transductant lines consist of undifferentiated embryonal carcinoma cells as judged by morphology, tumorigenicity in 129/Sv mice, and cell-surface antigenic markers. Analysis of the integrated recombinant viral genes by Southern blot hybridization revealed that some of the lines have single copies, whereas others have multiple copies, probably in multiple sites. Although these transductant lines contained many copies of helper Mo-MuLV integrated in the cellular genome, expression of these helper viruses was not detected either by reverse transcriptase activity or by X-C plaque assay. Two F9tk--derived, G418-resistant transductant lines were superinfected with a second recombinant transducing virus that contains the herpes simplex virus thymidine kinase gene flanked by the Mo-MuLV LTR. The frequency of transduction to yield clones able to grow in hypoxanthine/aminopterin/thymidine medium was similar to that of the parental F9tk- cells. These results suggest that the expression of the neomycin-resistance gene, linked to MoMuLV LTR in the transductant embryonal carcinoma cell clones, is due to a cisacting mechanism(s).