gebhart/patrepeval huggingface dataset:
Modulation of cancer cell survival pathways using multivalent liposomal therapeutic antibody constructs (2007)

Various methods have been explored to enhance antibody-based cancer therapy. The use of multivalent antibodies or fragments against tumor antigens has generated a great deal of interest, as various cellular signals, including induction of apoptosis, inhibition of cell growth/survival, or internalization of the surface molecules, can be triggered or enhanced on extensive cross-linking of the target/antibody complex by the multivalent form of the antibody. The goal of the studies reported here was to develop multivalent antibody constructs via grafting of antibody molecules onto liposome membranes to enhance antibody activity. Using trastuzumab and rituximab as examples, up to a 25-fold increase in the antibody potency in cell viability assay was observed when the antibodies were presented in the multivalent liposome formulation. Key cell survival signaling molecules, such as phosphorylated Akt and phosphorylated p65 nuclear factor-kappaB, were down-regulated on treatment with multivalent liposomal trastuzumab and liposomal rituximab, respectively. Potent in vivo antitumor activity was shown for liposomal trastuzumab. The data presented here showed the potential of liposome technology to enhance the therapeutic effect of antibodies via a mechanism that modulates cell survival through clustering of the target/antibody complex.
A multiplier to enhance the speed of encryption/decryption (2006)

It has become increasingly common to implement discrete-algorithm based public-key protocols on elliptic curves over finite fields. The operations, especially multiplication, over finite fields affect greatly the speed of encryption/decryption. For this reason the contribution describes a fast multiplier for Elliptic Curve Cryptosystems over finite fields GF ((2m1)m2). This multiplier adopts mixed parallel-serial approaches., The number of clock cycles for one field multiplication can be reduced from former m= m2m1 to current m2 with less increase of hardware scales.
A Reasoning System for Composition Verification and Security Validation (2014)

The procedure to prove that a system-of-systems is composable and secure is a very difficult task. Formal methods are mathematically-based techniques used for the specification, development and verification of software and hardware systems. This paper presents a model-based framework for dynamic embedded system composition and security evaluation. Event Calculus is applied for modeling the security behavior of a dynamic system and calculating its security level with the progress in time. The framework includes two main functionalities: composition validation and derivation of security and performance metrics and properties. Starting from an initial system state and given a series of further composition events, the framework derives the final system state as well as its security and performance metrics and properties. We implement the proposed framework in an epistemic reasoner, the rule engine JESS with an extension of DECKT for the reasoning process and the JAVA programming language.
Dynamic Motion and Rearranged Molecular Shape of Heme in Myoglobin: Structural and Functional Consequences (2013)

Myoglobin, a simple oxygen binding protein, was reconstituted with various types of synthetic hemes to manipulate the heme-globin interactions. From the paramagnetic NMR analysis, small heme was found to rotate rapidly about the iron-histidine bond upon. This is a novel and typical example for the fluctuation of protein. The dynamic NMR analysis indicated that the 360° rotational rate of a small heme was 1,400 s-1 at room temperature. The X-ray analyses revealed that the tertiary structure of globin containing the smallest heme was closely similar to that of native protein despite extensive destruction of the specific heme-globin interactions. The functional analyses of O2 binding showed that the loose heme-globin contacts do not significantly affect the oxygen binding. On the other hand, the rearrangement of tetrapyrrole array and the non-planar deformation in porphyrin ring significantly affect the functional properties of myoglobin. These results, taken together, indicate that the essential factors to regulate the myoglobin function are hidden under the molecular shape of prosthetic group rather than in the nonbonded heme-globin contacts.
Transfer Learning by Mapping with Minimal Target Data (2008)

This paper introduces the single-entity-centered setting for transfer across two relational domains. In this setting, target domain data contains information about only a single entity. We present the SR2LR algorithm that finds an effective mapping of the source model to the target domain in this setting and demonstsrate its effectiveness in three relational domains. Our experiments additionally show that the most accurate model for the source domain is not always the best model to use for transfer.
A new recursive incremental algorithm for building minimal acyclic deterministic finite automata (2003)

This chapter presents a new algorithm for incrementally building minimal acyclic deterministic finite automata. Such minimal automata are a compact representation of a finite set of words (e.g. in a spell checker). The incremental aspect of such algorithms (where the intermediate automaton is minimal) facilitates the construction of very large automata in limited computer memory where other\n(nonincremental) algorithms would fail with intermediate data structures too large to fit in memory.
Adaptive Impedance Control Method for Industrial Manipulator Writing Based on Kalman Filter (2018)

This paper presents an adaptive impedance control method based on Kalman filter to write Chinese characters for industrial manipulator. Kalman filter is used to estimate the actual contact force. For safety, the contact force is controlled to maintain constant using the adaptive impedance control method. There is no need for the knowledge of the environment. A robot Chinese characters writing system is designed to write characters on a stiff board. The writing experiment results verified the performance of the proposed method, and the trajectory and force can be tracked simultaneously.
Distributed acoustic and vibration sensing via optical fractional Fourier transform reflectometry (2015)

Distributed acoustic sensing has been traditionally implemented using optical reflectometry. Here we describe an alternative to the common interrogation approaches. According to the new method the frequency of the source is varied sinusoidally with time. For a sufficiently high scan frequency there is a position along the fiber, z(0), for which the roundtrip time is half the scan period. Back-reflections from this point will generate a linear chirp at the receiver output. The Fractional Fourier Transform (FrFT) is used to analyze the receiver output and yields the reflection profile at z(0) and its vicinity. The method, which enables high spatial resolution at long distances with high scan rates, is demonstrated by detecting deliberate perturbations in the Rayleigh backscatter profile at the end of a 20km fiber with a scanning frequency of ~2.5kHz. The spatial resolution at this range and scan-rate is characterized by a measurement of the backscatter profile from a FBG's-array and is found to be ~2.8m.
Towards understanding the hydrodeoxygenation pathways of furfural–acetone aldol condensation products over supported Pt catalysts (2015)

Aiming at the valorisation of furfural-derived compounds, the hydrodeoxygenation of furfural–acetone condensation products has been studied using supported platinum catalysts.
Ultrasound imaging to monitor photothermal therapy – Feasibility study (2008)

This study investigates the feasibility of ultrasound imaging to monitor temperature changes during photothermal treatment. Experiments were performed on tissue-mimicking phantoms and ex-vivo animal tissue samples. Gold nanoparticles were utilized as photoabsorbers. Prior to laser irradiation, structural features of the phantoms and tissue were visualized by ultrasound imaging. Ultrasound thermal imaging, performed during laser heating, showed that the temperature elevation was localized to the region of embedded or injected nanoparticles. The results of our study suggest that ultrasound imaging is a candidate approach to remotely guide photothermal therapy.
A New Handoff Ordering and Reduction Scheme Based on Road Topology Information (2006)

In this paper, we present a scheme for handoff ordering and reduction by using location information and trajectory prediction of a mobile terminal as mobile devices of the future are likely to be equipped with accurate positioning and advanced data processing capabilities, we used this new feature for mobility predictions based on road topology information and change in received signal strength (DeltaRSS) of a mobile terminal. Every mobile terminal calculates its probability of handoff (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">HO</sub> ) and its target base station (BS) and this information is used by host BS for dynamic resource reservations. Comparison between traditional and proposed handoff schemes points to reduction in total number of handoffs and new call blocking as confirmed by simulation results
Quantifying the Relationship between the Maximum Achievable Voltage and Current Levels in Low-Bandgap Polymer Photovoltaics (2013)

A critical problem in the design of materials for organic photovoltaics is quantifying the driving force needed for efficient charge separation without losses associated with a large overpotential. Here, we directly measured the effect of the molecular driving force on the charge transfer rate in films of low-bandgap push–pull type polymers mixed with a series of fullerene-based molecular acceptors using broadband near-infrared transient absorption spectroscopy. By systematically tuning the absolute energy levels of the donor and acceptor, as well as the relative offset between them, we determine the minimum voltage loss required to achieve a high short circuit current. A molecular donor–acceptor framework provides a quantitative description of the charge transfer rate constants in our system and describes the scaling of the photogenerated current with S1–LUMO energy offset. These results point to potential efficiency gains for high performing polymer devices through recovery of additional voltage without sacrificing current output.
Robust place recognition for 3D range data based on point features (2010)

The problem of place recognition appears in different mobile robot navigation problems including localization, SLAM, or change detection in dynamic environments. Whereas this problem has been studied intensively in the context of robot vision, relatively few approaches are available for three-dimensional range data. In this paper, we present a novel and robust method for place recognition based on range images. Our algorithm matches a given 3D scan against a database using point features and scores potential transformations by comparing significant points in the scans. A further advantage of our approach is that the features allow for a computation of the relative transformations between scans which is relevant for registration processes. Our approach has been implemented and tested on different 3D data sets obtained outdoors. In several experiments we demonstrate the advantages of our approach also in comparison to existing techniques.
Penetration of cationic conditioning compounds into hair fibers: A TOF‐SIMS approach (2006)

Cationic conditioning compounds protect against hair damage caused by cosmetic chemical treatments and grooming practices. They also enhance the retention of moisture. However, the question as to whether they do this superficially by residing on the hair surface or by penetrating into the fiber remains unanswered. In this work, an attempt has been made to show the penetration of a low-molecular-weight cationic conditioning compound into the hair cortex using the time-of-flight secondary ion mass spectrometry (TOF SIMS) method, applied in earlier research to show the penetration of oils into hair. An example of the practical benefit of such penetration into the cortex in greatly improving the fatigue resistance of hair has been discussed.
肱骨干下1／3关节外骨折——功能支具与钢板固定的比较 (2007)

背景：肱骨干下1／3骨折有手术和非手术两种治疗方法，两种治疗方法的拥护者各持己见，但鲜有相互比较的资料。我们对这两种治疗方法进行了回顾性比较。 方法：从创伤骨科资料库确定的连续性51例肱骨干下1／3关节外闭合性骨折患者。其中，40例患者随访时间至少6个月或至骨折愈合，11例患者因随访不全被排除。19例患者行钢板螺钉固定，21例应用功能支具治疗。 结果：手术治疗组，1例固定失效，1例术后感染，1例因为术前桡神经麻痹没有恢复，而行肌腱转移术。3例患者术后出现桡神经麻痹，其中1例在术后3个月最后评估时仍然没有恢复。手术治疗的所有骨折均愈合，成角畸形均〈10°，1例患者肩、肘关节功能受限20°；非手术组，2例患者因主诊医生考虑骨折对线及桡神经麻痹，改行钢板固定。仅有1例患者在各平面均有〉30°的成角。2例患者在治疗期间发生皮肤破溃，经三角巾悬吊完成治疗。2例患者肘或肩关节功能受限≥20°。 结论：肱骨干下1／3关节外骨折，手术治疗可获得理想的对位，能更快的恢复功能，但是存在医原性神经损伤、感染及需要再次手术的风险。功能支具可能引起皮肤的问题和不同程度的成角畸形，但常可获得优良的活动范围与功能。 可信水平：治疗性研究，Ⅲ级，进一步可信度参见作者介绍。
Shared relationship analysis: ranking set cohesion and commonalities within a literature-derived relationship network (2004)

We first establish a network of related objects by their co-occurrence within MEDLINE records. A set of objects within this network can then be queried to identify shared relationships, and a method is presented to score their statistical relevance by comparing observed frequencies with what would be expected in a random network model. Using Gene Ontology (GO) categories, we demonstrate that this method enables a quantitative ranking of the 'cohesiveness' of a set of objects and, importantly, allows other objects related to this set to be identified and evaluated for their 'cohesion' to it. Supplemental information: A list of ranked genes related to each GO category analyzed can be found at http://innovation.swmed.edu/IRIDESCENT/GO_relationships.htm
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENINGKATAN KINERJA KARYAWAN PADA HOTEL DINASTI MAKASSAR (2017)

Adil Gestal Taher. "Analysis of Factors Affecting Employee Performance Improvement At Hotel Dinasti Makassar". Thesis, Management Studies Program, guided by H.A. Arifuddin Mane and Lukman Setiawan.\nThis research was conducted at the Hotel Dinasti Makassar to examine the factors that affect performance improvement. In this study was to determine whether the factors that most influence employee performance improvement.\nThis study was conducted using questionnaires to all employees of the Dynasty Hotel Makassar, the data obtained were then processed using the method of qualitative analysis and multiple regression analysis. Number of questionnaires were processed totaling 60 questionnaire.\nThese results indicate that employee performance, motivation, incentives, and education, positive and significant impact on employee performance improvement.
Label-free electrical quantification of the dielectrophoretic response of DNA (2008)

A purely electrical sensing scheme is presented that determines the concentration of macromolecules in solution by measuring the capacitance between planar microelectrodes. Concentrations of DNA in the ng/mL range have been used in samples of 1 muL volume. The method has been applied to the characterisation of the dielectrophoretic response of DNA without the need for any chemical modifications. The influence of electrical parameters like duty cycle, voltage and frequency has been investigated. The results are in good agreement with data from dielectrophoretic studies on fluorescently labelled DNA. Extension of the method down to the single molecule level appears feasible.PACS: 87.50.ch, 87.80.Fe, 87.85.fK.
Reassignment of Scattered Emission Photons in Multifocal Multiphoton Microscopy (2014)

Multifocal multiphoton microscopy (MMM) achieves fast imaging by simultaneously scanning multiple foci across different regions of specimen. The use of imaging detectors in MMM, such as CCD or CMOS, results in degradation of image signal-to-noise-ratio (SNR) due to the scattering of emitted photons. SNR can be partly recovered using multianode photomultiplier tubes (MAPMT). In this design, however, emission photons scattered to neighbor anodes are encoded by the foci scan location resulting in ghost images. The crosstalk between different anodes is currently measured a priori, which is cumbersome as it depends specimen properties. Here, we present the photon reassignment method for MMM, established based on the maximum likelihood (ML) estimation, for quantification of crosstalk between the anodes of MAPMT without a priori measurement. The method provides the reassignment of the photons generated by the ghost images to the original spatial location thus increases the SNR of the final reconstructed image.
Effect of Hydrophobicity of Ion Exchange Groups of Anion Exchange Membranes on Permselectivity between Two Anions (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of Hydrophobicity of Ion Exchange Groups of Anion Exchange Membranes on Permselectivity between Two AnionsToshikatsu Sata, Takanori Yamaguchi, and Koji MatsusakiCite this: J. Phys. Chem. 1995, 99, 34, 12875–12882Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/j100034a028https://doi.org/10.1021/j100034a028research-articleACS PublicationsRequest reuse permissionsArticle Views1427Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
On the Coherence between Comments and Implementations in Source Code (2015)

Source code comments provide useful information on the implementation of a software and on the intent behind design decisions and goals. Writing informative and useful comments is far from being a trivial task. Moreover, source code comments tend to remain mostly unchanged during maintenance activities. As a consequence, the information provided in the comment of a method and in its corresponding implementation may be not coherent with each other (i.e., The comment does not properly describe the implementation). In this paper, we present the results of a manual assessment on the coherence between comments and implementations of 3636 methods, gathered from 3 Java open source software systems (for one of these systems, we considered 2 different subsequent versions). Resulting evaluations have been collected in a dataset, we made publicly available on the web. The defined protocol used for the creation of this dataset is also described. This lets researchers evaluate the goodness of our dataset and eases its future possible extensions. Another contribution of our paper consists in investigating on a possible link between coherence and lexical similarity between source code and comments. Our preliminary outcomes suggest that this similarity is higher in case the comment of methods and their implementations are coherent. However, the obtained similarity values are generally low and are not much higher than those for non-coherent method implementations and comments.
Selfishness and altruism on the MISO interference channel: the case of partial transmitter CSI (2009)

We study the achievable ergodic rate region of the two-user multiple-input single-output interference channel, under the assumptions that the receivers treat interference as additive Gaussian noise and the transmitters only have statistical channel knowledge. Initially, we provide a closed-form expression for the ergodic rates and derive the Nash-equilibrium and zero-forcing transmit beamforming strategies. Then, we show that combinations of the aforementioned selfish and altruistic, respectively, strategies achieve Pareto-optimal rate pairs.
Theoretical analysis of an electrically addressed viscoelastic spatial light modulator (1987)

The time behavior and the spatial-frequency response of a deformable viscoelastic control layer are analyzed in view of its intended use as a spatial light modulator in a solid-state light valve. Direct electrical addressing of the viscoelastic spatial light modulator (VSLM) is incorporated in the analytical model by means of electrostatic potentials that vary sinusoidally in one lateral dimension. First, the electrostatic boundary-value problem of the VSLM is solved, and the resulting compressional forces are determined; then the elastohydrodynamic boundary-value problem is solved on the basis of the so-called Voigt model, and the mechanical stresses acting on the VSLM are calculated. Finally, analytical solutions for the deformation amplitude are found by use of equilibrium conditions for the electrostatic and the viscoelastic stresses. The resulting deformation amplitudes of the VSLM are given as functions of time and of spatial frequency with viscosity, shear modulus, surface tension, layer thickness, electric bias, and spatial modulation depth as parameters. An extensive discussion of these results concludes the present study.
A novel 3T3-L1 preadipocyte variant that expresses PPARγ2 and RXRα but does not undergo differentiation (1998)

This report describes a novel adipocyte-like cell line termed 3T3-L1/RB1 that was derived from preadipocyte cell line, 3T3-L1. The 3T3-L1/RB1 cells continued to divide after reaching confluence, formed foci, and constitutively expressed a low level of adipose fatty acid binding protein (A-FABP) mRNA. However, 3T3L-1/RB cells did not undergo terminal differentiation as indicated by the failure of insulin and thiazolidendiones to induce the expression of A-FABP, lipoprotein lipase, and fatty acid synthase. We hypothesized that the 3T3-L1/RB1 variant did not respond to differentiation stimuli because it did not express either peroxisomal proliferator activated receptor gamma2 (PPARgamma2) or its heterodimer partner, retinoid X receptor alpha (RXRalpha). Surprisingly, Western blots revealed that 3T3-L1/ RB1 cells contained both PPARgamma2 and RXRalpha proteins at levels equal to or greater than that of the parent cell line. However, gel retardation assays using the adipose response element from A-FABP and nuclear protein extracts from 3T3-L1/RB1 cells treated with insulin or pioglitazone revealed that nuclear protein extracts from 3T3-L1/RB1 cells had very little ability to bind the PPARgamma2 recognition sequence of the A-FABP gene. These data suggest that the 3T3-L1/RB1 variant contains a mutation that may prevent ligand activation of PPARgamma2, and the subsequent conversion of 3T3-L1/RB1 cells to mature fat cells.