gebhart/patrepeval huggingface dataset:
Passive wireless temperature sensing with piezoelectric MEMS resonators (2015)

For the first time, a lateral-extensional piezoelectric MEMS resonator is utilized to enable wireless passive temperature sensing with an accuracy of less than 0.1°C at 1m distance. The high quality factor (2900) and low motional resistance (147Ω) of a 990MHz thin-film piezoelectric-on-silicon (TPoS) resonator are exploited to accurately determine the temperature of the subject by monitoring the induced change in the resonance frequency. The resonator is directly connected to an antenna and is excited wirelessly by a pulse-modulated sinusoidal signal. The decaying signal from the resonator is then recorded and the resonance frequency is determined from the frequency spectrum of the resonator's decaying response. The wireless temperature measurement was extended to a 3m distance with an interrogation signal power of 500mW using 5dBi gain antennas.
Passive Control of Pressure Loads Using Porosity (1991)

A device is provided for controlling pressure loading of a member caused by a fluid moving past the member or the member moving through a fluid. The device consists of a porous skin mounted over the solid surface of the member and separated from the solid surface by a plenum. Fluid from an area exerting high pressure on the member may enter the plenum through the porous surface and exit into an area exerting a lower pressure on the member, thus controlling pressure loading of the member.
Access method concurrency with recovery (1992)

Providing high concurrency in B + -trees has been studied extensively. But few efforts have been documented for combining concurrency methods with a recovery scheme that preserves well-formed trees across system crashes. We describe an approach for this that works for a class of index trees that is a generalization of the B link -tree. A major feature of our method is that it works with a range of different recovery methods. It achieves this by decomposing structure changes in an index tree into a sequence of atomic actions, each one leaving the tree well-formed and each working on a separate level of the tree. All atomic actions on levels of the tree above the leaf level are independent of database transactions, and so are of short duration.
Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine (2007)

Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ peptide receptor (NOP). N/OFQ causes hypotension and vasodilation, and we aimed to determine the role of histamine in inflammatory microvascular responses to N/OFQ. Male Wistar rats (220-300 g, n = 72) were anesthetized with thiopental (30 mg/kg bolus, 40-90 mg x kg(-1) x h(-1) iv), and the mesentery was prepared for fluorescent intravital microscopy using fluorescein isothiocyanate-conjugated BSA (FITC-BSA, 0.25 ml/100 g iv) or 1 microm fluorescently labeled microspheres. N/OFQ (0.6-60 nmol/kg iv) caused hypotension (SAP, baseline: 154 +/- 11 mmHg, 15 nmol/kg N/OFQ: 112 +/- 10 mmHg, P = 0.009), vasodilation (venules: 23.9 +/- 1.2 microm, 26.7 +/- 1.2 microm, P = 0.006), macromolecular leak (interstitial gray level FITC-BSA: 103.7 +/- 3.4, 123.5 +/- 11.8, P = 0.009), and leukocyte adhesion (2.0 +/- 0.9, 15.2 +/- 0.9/100 microm, P = 0.036). Microsphere velocity also decreased (venules: 1,230 +/- 370 microm/s, P = 0.037), but there were no significant changes in blood flow. Flow cytometry measured a concurrent increase in neutrophil expression of cd11b with N/OFQ vs. controls (Geo mean fluorescence: 4.19 +/- 0.13 vs. 2.06 +/- 0.38, P < 0.05). The NOP antagonist [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101; 60 and 150 nmol/kg iv), H(1) and H(2)antagonists pyrilamine (mepyramine, 1 mg/kg iv) and ranitidine (1 mg/kg iv), and mast cell stabilizer cromolyn (1 mg x kg(-1) x min(-1)) also abolished vasodilation and macromolecular leak to N/OFQ in vivo (P < 0.05), but did not affect hypotension. Isolated mesenteric arteries (approximately 200 microm, n = 25) preconstricted with U-46619 were also mounted on a pressure myograph (60 mmHg), and both intraluminally and extraluminally administered N/OFQ (10(-5) M) caused dilation, inhibited by pyrilamine in the extraluminal but not the intraluminal (control: -6.9 +/- 3.8%; N/OFQ: 32.6 +/- 8.4%; pyrilamine: 31.5 +/- 6.8%, n = 18, P < 0.05) experiments. We conclude that, in vivo, mesenteric microvascular dilation and macromolecular leak occur via N/OFQ-NOP-mediated release of histamine from mast cells. Therefore, N/OFQ-NOP has an important role in microvascular inflammation, and this may be targeted during disease, particularly as we have proven that UFP-101 is an effective antagonist of microvascular responses in vivo.
Sustained, localized salicylic acid delivery enhances diabetic bone regeneration via prolonged mitigation of inflammation (2016)

Diabetes is a metabolic disorder caused by insulin resistance and/or deficiency and impairs bone quality and bone healing due to altered gene expression, reduced vascularization, and prolonged inflammation. No effective treatments for diabetic bone healing are currently available, and most existing treatments do not directly address the diabetic complications that impair bone healing. We recently demonstrated that sustained and localized delivery of salicylic acid (SA) via an SA-based polymer provides a low-cost approach to enhance diabetic bone regeneration. Herein, we report mechanistic studies that delve into the biological action and local pharmacokinetics of SA-releasing polymers shown to enhance diabetic bone regeneration. The results suggest that low SA concentrations were locally maintained at the bone defect site for more than 1 month. As a result of the sustained SA release, a significantly reduced inflammation was observed in diabetic animals, which in turn, yielded reduced osteoclast density and activity, as well as increased osteoblastogenesis. Based upon these results, localized and sustained SA delivery from the SA-based polymer effectively improved bone regeneration in diabetic animals by affecting both osteoclasts and osteoblasts, thereby providing a positive basis for clinical treatments. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2595-2603, 2016.
Fundamentals of synchronization in chaotic systems, concepts, and applications (1997)

The field of chaotic synchronization has grown considerably since its advent in 1990. Several subdisciplines and "cottage industries" have emerged that have taken on bona fide lives of their own. Our purpose in this paper is to collect results from these various areas in a review article format with a tutorial emphasis. Fundamentals of chaotic synchronization are reviewed first with emphases on the geometry of synchronization and stability criteria. Several widely used coupling configurations are examined and, when available, experimental demonstrations of their success (generally with chaotic circuit systems) are described. Particular focus is given to the recent notion of synchronous substitution-a method to synchronize chaotic systems using a larger class of scalar chaotic coupling signals than previously thought possible. Connections between this technique and well-known control theory results are also outlined. Extensions of the technique are presented that allow so-called hyperchaotic systems (systems with more than one positive Lyapunov exponent) to be synchronized. Several proposals for "secure" communication schemes have been advanced; major ones are reviewed and their strengths and weaknesses are touched upon. Arrays of coupled chaotic systems have received a great deal of attention lately and have spawned a host of interesting and, in some cases, counterintuitive phenomena including bursting above synchronization thresholds, destabilizing transitions as coupling increases (short-wavelength bifurcations), and riddled basins. In addition, a general mathematical framework for analyzing the stability of arrays with arbitrary coupling configurations is outlined. Finally, the topic of generalized synchronization is discussed, along with data analysis techniques that can be used to decide whether two systems satisfy the mathematical requirements of generalized synchronization. (c) 1997 American Institute of Physics.
Low-aspect-ratio torsatron for high-beta toroidal confinement (1981)

A new type of torsatron configuration is characterized by: (1) flux-surface symmetry compatible with high-beta optimization of a tokamak-torsatron hybrid, and (2) unentangled coil topology.
Wavelength division sensing RF vibrometer (2011)

A wavelength division sensing RF vibrometer which is implemented as a tunable carrier frequency Doppler radar sensor was used for the first time to accurately measure mechanical vibrations of complex patterns. The amplitude ratio of a pair of baseband harmonics under different carrier wavelengths was used to obtain the vibration patterns. A software-controlled PLL was built to generate carrier frequencies from 5.5 to 6.5 GHz. The accuracy of the recovered vibration pattern using the noncontact RF vibrometer rivals other contact measurement instruments, such as LVDT and accelerometer.
Hyperquenching for protein cryocrystallography (2006)

When samples having volumes characteristic of protein crystals are plunge cooled in liquid nitrogen or propane, most cooling occurs in the cold gas layer above the liquid. By removing this cold gas layer, cooling rates for small samples and modest plunge velocities are increased to 1.5 × 10(4) K s(-1), with increases of a factor of 100 over current best practice possible with 10 μm samples. Glycerol concentrations required to eliminate water crystallization in protein-free aqueous mixtures drop from ∼28% w/v to as low as 6% w/v. These results will allow many crystals to go from crystallization tray to liquid cryogen to X-ray beam without cryoprotectants. By reducing or eliminating the need for cryoprotectants in growth solutions, they may also simplify the search for crystallization conditions and for optimal screens. The results presented here resolve many puzzles, such as why plunge cooling in liquid nitrogen or propane has, until now, not yielded significantly better diffraction quality than gas-stream cooling.
Inhibition of Idiotype—Anti-Idiotype Interaction for Detection of a Parasite Antigen: a New Immunoassay (1982)

Described in this report is an immunoradiometric assay of general applicability that is based on a new principle: the inhibition of the interaction between monoclonal antibodies by an antigen. The advantages of this assay are that it measures concentrations of single epitopes, purified antigen is not required, and the reagents can be obtained in unlimited amounts and are homogeneous. Its features are particularly attractive when the antigen has not been purified and is a minor component of a complex mixture of molecule.
Kangaroo (2016)

Despite the importance and widespread use of range data, e.g., time intervals, spatial ranges, etc., little attention has been devoted to study the processing and querying of range data in the context of big data. The main challenge relies in the nature of the traditional index structures e.g., B-Tree and R-Tree, being centralized by nature, and hence are almost crippled when deployed in a distributed environment. To address this challenge, this paper presents Kangaroo, a system built on top of Hadoop to optimize the execution of range queries over range data. The main idea behind Kangaroo is to split the data into non-overlapping partitions in a way that minimizes the query execution time. Kangaroo is query workload-aware, i.e., results in partitioning layouts that minimize the query processing time of given query patterns. In this paper, we study the design challenges Kangaroo addresses in order to be deployed on top of a distributed file system, i.e., HDFS. We also study four different partitioning schemes that Kangaroo can support. With extensive experiments using real range data of more than one billion records and real query workload of more than 30,000 queries, we show that the partitioning schemes of Kangaroo can significantly reduce the I/O of range queries on range data.
Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging (2020)

Laser Doppler holography (LDH) is a full-field interferometric imaging technique recently applied in ophthalmology to measure blood flow, a parameter of high clinical interest. From the temporal fluctuations of digital holograms acquired at ultrafast frame rates, LDH reveals retinal and choroidal blood flow with a few milliseconds of temporal resolution. However, LDH experiences difficulties to detect slower blood flow as it requires to work with low Doppler frequency shifts which are corrupted by eye motion. We here demonstrate the use of a spatio-temporal decomposition adapted from Doppler ultrasound that provides a basis appropriate to the discrimination of blood flow from eye motion. A singular value decomposition (SVD) can be used as a simple, robust, and efficient way to separate the Doppler fluctuations of blood flow from those of strong spatial coherence such as eye motion. We show that the SVD outperforms the conventional Fourier based filter to reveal slower blood flow, and dramatically improves the ability of LDH to reveal vessels of smaller size or with a pathologically reduced blood flow.
Design of a Fluoro-olefin Cytidine Nucleoside as a Bioprecursor of a Mechanism-Based Inhibitor of Ribonucleotide Reductase (1996)

MDL 101,731 (3) is a fluoro olefin cytidine nucleoside designed as a bioprecursor of a mechanism-based inhibitor of ribonucleotide diphosphate reductase (RDPR) targeted for the treatment of tumors. The rationale for the use of a fluoro olefin in the design of 3 are discussed. A new stereospecific method to fluoro olefins was developed as a key step in the synthesis of MDL 101,731. Studies showing inactivation of both the R1 and R2 subunits of RDPR from E. coli by the diphosphate of MDL 101,731 are presented, and a proposed mechanism for the process is discussed. In addition, the antitumor profile of the drug is outlined. MDL 101,731 has recently entered clinical trials for the treatment of solid tumors in the US and Japan.
First drop dissimilarity in drop-on-demand inkjet devices (2011)

As inkjet printing technology is increasingly applied in a broader array of applications, careful characterization of its method of use is critical due to its inherent sensitivity. A common operational mode in inkjet technology known as drop-on-demand ejection is used as a way to deliver a controlled quantity of material to a precise location on a target. This method of operation allows ejection of individual or a sequence (burst) of drops based on a timed trigger event. This work presents an examination of sequences of drops as they are ejected, indicating a number of phenomena that must be considered when designing a drop-on-demand inkjet system. These phenomena appear to be driven by differences between the first ejected drop in a burst and those that follow it and result in a break-down of the linear relationship expected between driving amplitude and drop mass. This first drop, as quantified by high-speed videography and subsequent image analysis, can be different in morphology, trajectory, velocity, and volume from subsequent drops within a burst. These findings were confirmed orthogonally by both volume and mass measurement techniques which allowed quantitation down to single drops.
Engineering Efficient Photon Upconversion in Semiconductor Heterostructures (2018)

Photon upconversion is a photophysical process in which two low-energy photons are converted into one high-energy photon. Photon upconversion has broad appeal for a range of applications from biomedical imaging and targeted drug release to solar energy harvesting. Current upconversion nanosystems, including lanthanide-doped nanocrystals and triplet-triplet annihilation molecules, have achieved upconversion quantum yields on the order of 10-30%. However, the performance of these materials is hampered by inherently narrow absorption cross sections and fixed energy levels originating in atomic, ionic, or molecular states. Semiconductors, on the other hand, have inherently wide absorption cross sections. Moreover, recent advances enable the synthesis of colloidal semiconductor nanoparticles with complex heterostructures that can control band alignments and tune optical properties. We synthesize and characterize a three-component heterostructure that successfully upconverts photons under continuous-wave illumination and solar-relevant photon fluxes. The heterostructure is composed of two cadmium selenide quantum dots (QDs), an absorber and emitter, spatially separated by a cadmium sulfide nanorod (NR). We demonstrate that the principles of semiconductor heterostructure engineering can be applied to engineer improved upconversion efficiency. We first eliminate electron trap states near the surface of the absorbing QD and then tailor the band gap of the NR such that charge carriers are funneled to the emitting QD. When combined, these two changes result in a 100-fold improvement in photon upconversion performance.
Pyroelectric properties of the alanine and arsenic-doped triglycine sulfate single crystals (1983)

Arsenic-doped triglycine sulfate single crystals show an enhancement in pyroelectric coefficients and the pyroelectric figures of merit p/K and p/√K by a factor of 2.2 over those of pure triglycine sulfate single crystals at the most desirable operating temperature of the pyroelectric sensors, ≂25 °C. The crystals are inexpensive to produce and show useful pyroelectric properties.
Molecular Cloning and Characterization of a cDNA Encoding Proline Transporter in Rice (2000)

A cDNA encoding a proline (Pro) transporter (ProT) was isolated and characterized from a cDNA library prepared from 14-d-old seedlings of Oryza sativa cv. Akibare. The deduced amino acid sequence of the rice ProT protein (OsProT) had 68.8% homology to the ProT protein 1 from Arabidopsis thaliana and 59.6% homology to that from Lycopersicon esculentum. Northern blot analysis revealed that the gene for OsProT (OsProT) was expressed in all organs examined, comparatively strongly in leaf sheath and stem. Salt treatment did not induce expression of OsProT but strongly induced expression of the gene for delta1-pyrroline-5-carboxylate synthetase (P5CS), a key enzyme in Pro biosynthesis. Southern blot analysis revealed that OsProT has a gene family. OsProT specifically transported L-Pro in a transport assay using Xenopus laevis oocytes.
ChemInform Abstract: Synthesis and Biological Activity of Novel Epothilone Aziridines. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined (2016)

Factor H binding protein (fHbp) is a lipoprotein of Neisseria meningitidis important for the survival of the bacterium in human blood and a component of two recently licensed vaccines against serogroup B meningococcus (MenB). Based on 866 different amino acid sequences this protein is divided into three variants or two families. Quantification of the protein is done by immunoassays such as ELISA or FACS that are susceptible to the sequence variation and expression level of the protein. Here, selected reaction monitoring mass spectrometry was used for the absolute quantification of fHbp in a large panel of strains representative of the population diversity of MenB. The analysis revealed that the level of fHbp expression can vary at least 15-fold and that variant 1 strains express significantly more protein than variant 2 or variant 3 strains. The susceptibility to complement-mediated killing correlated with the amount of protein expressed by the different meningococcal strains and this could be predicted from the nucleotide sequence of the promoter region. Finally, the absolute quantification allowed the calculation of the number of fHbp molecules per cell and to propose a mechanistic model of the engagement of C1q, the recognition component of the complement cascade.
Automatic Modeling of Opaque Code for JavaScript Static Analysis (2019)

Static program analysis often encounters problems in analyzing library code. Most real-world programs use library functions intensively, and library functions are usually written in different languages. For example, static analysis of JavaScript programs requires analysis of the standard built-in library implemented in host environments. A common approach to analyze such opaque code is for analysis developers to build models that provide the semantics of the code. Models can be built either manually, which is time consuming and error prone, or automatically, which may limit application to different languages or analyzers. In this paper, we present a novel mechanism to support automatic modeling of opaque code, which is applicable to various languages and analyzers. For a given static analysis, our approach automatically computes analysis results of opaque code via dynamic testing during static analysis. By using testing techniques, the mechanism does not guarantee sound over-approximation of program behaviors in general. However, it is fully automatic, is scalable in terms of the size of opaque code, and provides more precise results than conventional over-approximation approaches. Our evaluation shows that although not all functionalities in opaque code can (or should) be modeled automatically using our technique, a large number of JavaScript built-in functions are approximated soundly yet more precisely than existing manual models.
Leveraging Artifact Trees to Evolve and Reuse Safety Cases (2019)

Safety Assurance Cases (SACs) are increasingly used to guide and evaluate the safety of software-intensive systems. They are used to construct a hierarchically organized set of claims, arguments, and evidence in order to provide a structured argument that a system is safe for use. However, as the system evolves and grows in size, a SAC can be difficult to maintain. In this paper we utilize design science to develop a novel solution for identifying areas of a SAC that are affected by changes to the system. Moreover, we generate actionable recommendations for updating the SAC, including its underlying artifacts and trace links, in order to evolve an existing safety case for use in a new version of the system. Our approach, Safety Artifact Forest Analysis (SAFA), leverages traceability to automatically compare software artifacts from a previously approved or certified version with a new version of the system. We identify, visualize, and explain changes in a Delta Tree. We evaluate our approach using the Dronology system for monitoring and coordinating the actions of cooperating, small Unmanned Aerial Vehicles. Results from a user study show that SAFA helped users to identify changes that potentially impacted system safety and provided information that could be used to help maintain and evolve a SAC.