gebhart/patrepeval huggingface dataset:
Neuropathological Diagnosis of Human Prion Disease: Morphological Studies (2003)

The neuropathology of the classical human prion diseases, Creutzfeldt-Jakob dtsease (CJD), Gerstmann-Straussler-Scheinker syndrome (GSS), and kuru, is characterized by four main features* spongiform change, neuronal loss, ghiosts, and amyloid plaque formation (1–3. These features are shared with prion diseases in animals; the recognition of these similarities prompted the first attempts to transmit a human priori disease (kuru) to a primate in 1966 (4, followed by CJD in 1968 (5) and GSS in 1981 (6). These neuropathological features have formed the basis of the morphological diagnosts of human prion diseases for many years, although it was recognized that these changes are enormously variable both from case to case and within the central nervous system (CNS) in individual cases (7). In this respect, it is interesting to note that the original case reported by Creutzfeldt (8, 9) and two of the original cases reported by Jakob (10–12) do not show any of these characteristic neuropathological features; the diagnosis in these cases remains uncertain on review (7, 13). However, at least two of Jakob’s original cases show typical neuropathological changes and other cases subsequently reported from his laboratory (including the members of the Backer family) also exhibited classical histological features (12, 14). It is also of interest to note that prion protein (PrP) gene analysis has recently been performed on one of the Backer family cases, showing a codon 178 Asn mutation with met/val at codon 129 (15. This genotype has been described in other familial forms of human prion disease (16 (see Chapter 2).
Large Cross-Phase Modulation between Slow Copropagating Weak Pulses in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mmultiscripts><mml:mi>Rb</mml:mi><mml:mprescripts/><mml:none/><mml:mn>87</mml:mn></mml:mmultiscripts></mml:math> (2006)

We propose a scheme to generate double electromagnetically induced transparency and optimal cross-phase modulation for two slow, copropagating pulses with matched group velocities in a single species of atom, namely 87Rb. A single pump laser is employed and a homogeneous magnetic field is utilized to avoid cancellation effects through the nonlinear Zeeman effect. We suggest a feasible preparational procedure for the atomic initial state to achieve matched group velocities for both signal fields.
An inerter-based electromagnetic device and its application in vehicle suspensions (2015)

This paper proposes a novel inerter-based electromagnetic device and investigates its performance as a vehicle suspension strut. The inerter-based electromagnetic device is obtained by placing the flywheel employed in an existing inerter prototype into a constant magnetic field. During rotation of the flywheel, the flywheel is doing the magnetic line cutting motion, which makes the flywheel perform as a Faraday generator. The influences of different types of loads on the behaviour of the inerter-based electromagnetic device are analyzed, and it is shown that the resistive, capacitive and inductive loads can contribute to the damping, the inertance, and the stiffness of the whole device, respectively. Moreover, the proposed device can also be used to realize higher-order mechanical admittances by using electrical circuits. The performance of the device as a suspension strut is also studied. Numerical simulations show that the proposed device can not only provide improvements on the suspension performance (ride comfort and road holding) compared with the conventional strut, but also generate an amount of electric energy that can be utilized by other parts of the vehicle.
A GPU Laplacian solver for diffusion curves and Poisson image editing (2009)

We present a new Laplacian solver for minimal surfaces---surfaces having a mean curvature of zero everywhere except at some fixed (Dirichlet) boundary conditions. Our solution has two main contributions: First, we provide a robust rasterization technique to transform continuous boundary values (diffusion curves) to a discrete domain. Second, we define a variable stencil size diffusion solver that solves the minimal surface problem. We prove that the solver converges to the right solution, and demonstrate that it is at least as fast as commonly proposed multigrid solvers, but much simpler to implement. It also works for arbitrary image resolutions, as well as 8 bit data. We show examples of robust diffusion curve rendering where our curve rasterization and diffusion solver eliminate the strobing artifacts present in previous methods. We also show results for real-time seamless cloning and stitching of large image panoramas.
Subcellular Localization of the<i>Staphylococcus aureus</i>Heme Iron Transport Components IsdA and IsdB (2009)

Staphylococcus aureus is a human pathogen that represents a tremendous threat to global public health. An important aspect of S. aureus pathogenicity is the ability to acquire iron from its host during infection. In vertebrates, iron is sequestered predominantly within heme, the majority of which is bound by hemoglobin. To acquire iron, S. aureus binds hemoglobin, removes heme, and transports it into the cytoplasm, where heme is degraded. This process is carried out by the iron-regulated surface determinant system (Isd); however, the mechanism by which hemoglobin recognition occurs is not completely understood. Here we report that the surface receptor components of the Isd system, IsdA and IsdB, physically interact with each other and are anchored to a discrete location within the cell wall. This organized localization pattern is dependent upon the iron status of the bacterium. Furthermore, we have found that hemoglobin colocalizes with IsdB at discrete sites within the cell wall. Virulence studies revealed that IsdB is required for the efficient colonization of the heart and that IsdB is differentially expressed within infected organs, suggesting that S. aureus experiences various degrees of iron starvation depending on the site of infection. These findings significantly expand our understanding of hemoglobin iron acquisition and demonstrate an orchestrated pattern of regulation and localization for the S. aureus heme iron acquisition system.
Dentin Hydraulic Conductance: Changes Produced by Red Blood Cells (1981)

Red blood cells were forced into dentinal tubules in vitro under known hydrostatic pressures. This resulted in a 1 7-fold fall in the hydraulic conductance of dentin. The histologic appearance of red blood cells forced into dentin in vitro was very similar to that found in dog pulps following full crown preparations without adequate cooling in vivo.
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. (1982)

Insulin activates a tyrosine-specific cAMP-independent protein kinase when added directly to detergent extracts of differentiated 3T3-L1 adipocytes and humal placental membranes. The kinase is also activated by antibody to the insulin receptor and, to a lesser extent, by proinsulin. It catalyzes the phosphorylation of the 92,000-dalton component of the insulin receptor, histone, and casein; in each case, tyrosine is the principal amino acid modified. Under the conditions used to activate the kinase, insulin does not affect the rate of dephosphorylation of the receptor or of histone. The insulin-activated kinase is copurified with the human placental insulin receptor until the final elution from insulin-Sepharose. It remains to be established whether the kinase and the insulin receptor are separate molecules.
A privilege management and enforcement system for distributed resource sharing (2002)

The Internet has been identified as one of the most dangerous aspects for an organization in today's information based world. Unauthorized access, misuse, and manipulation of data can create havoc. We have chosen a distributed environment with thousands of users and tens of thousands of resources to illustrate an approach to solve this problem. We have developed a system for easy administration and enforcement of controlled access. Distributed, delegated management of resources is at the core of the project. For portability, the enforcement system is established between the operating system and the user rather than being embedded in the operating system. In particular, we have developed management and access methods for end user access to resources via the Internet including X Windows and World Wide Web based interfaces, and DCE based authentication and authorization. The environment for this project is the Distributed Informatics Computing and Collaborative Environments project associated with the US Department of Energy's Energy Science Network. This project is a joint effort between the Continuous Electron Beam Accelerator Facility (CEBAF), the Chinese Institute of High Energy Physics, and Old Dominion University.
Geometric Mapping for Sustained Indoor Autonomy (2018)

Simultaneous localization and mapping (SLAM) is the first step for enabling autonomous operation in unknown and changing environments. Many applications such as service and assistive robots require constant movement between different regions along with accurate navigation and localization at any point in time. Algorithms for SLAM have matured greatly over the last few years and can accommodate different sensors, computing requirements as well as environments for use. However, for long-term autonomy indoors, reasoning with a large volume of RGB-D data is still a major challenge. In this work, we propose a pipeline that attributes semantics, more specifically cuboidal structure, to observed objects, uses them as landmarks for mapping and thereby reduces the dimensionality of the represented map greatly. We chose cuboids, because many common urban scenes (such as offices, homes, malls) contain cuboidal objects (such as cabinets, tables, shelves). We develop a metric to perform such attribution consistently so they can be used as landmarks for mapping/navigation. We have tested our pipeline on three different datasets and show that we can reduce the map representation significantly while maintaining localization accuracy in all of them. Our vision is that attributing low-level semantics such as one presented in this work would make long-term autonomy computationally tractable.
Efficient subspace approximation algorithms (2007)

Confronted with high-dimensional data arising from either word-document count, global climate patterns or any one of the myriad other sources, most scientific approaches extract a good low-dimensional summary. This desire to reduce dimensionality may be seen as a consequence of Occam's Razor, and the scientific methodologies we have in mind include those from data mining and statistics.
Comparison between the ripple techniqueand the directcalibration method for characterisation of directional devices (2000)

A comparison between two different methods for measurement of directivity and test port match of directional couplers and bridges is presented. One of them, the popular ripple technique, is scalar. The other method, the so-called direct calibration method as derived by Juroshek (1997), with slight differences for the simultaneous measurement of both parameters, is vectorial. The two methods make use of a vector network analyser (VNA) and the calibrations performed are verified against known standards. The uncertainty associated with both techniques is computed.
Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences (2008)

We have developed a new red fluorogenic compound derived from naphthorhodamine for a reduction-triggered fluorescence probe to sense oligonucleotides. The fluorogenic reaction between naphthorhodamine azide derivatives and reducing reagents such as triphenylphosphine (TPP) on the DNA target does not use any enzyme or reagent, and fluoresces at 650 nm. The probes were used for dual color detection of a single nucleotide difference on the leukemia-related bcr/abl gene.
The Applications of Reactive Dyes in Enzyme and Protein Downstream Processing (1988)

Downstream processing of proteins is often a key factor in the overall process of satisfying product specifications and meeting current commercial demands. In this context, affinity chromatography and other techniques based on the affinity concept have revolutionized protein purification technology, although they have failed to demonstrate their broader applicability at the process scale. On the other hand, reactive dyes offer many advantages as pseudoaffinity media and in many occasions have successfully circumvented problems associated with conventional affinity ligands. The main features of reactive dyes include their broad spectrum of interaction with proteins, low cost, ready availability, high reactivity, ease of immobilization, and both biological and chemical stability. Consequently, dye-ligand media now find application in both analytical and process-scale purification of proteins by techniques such as low- and high-pressure performance affinity chromatography, affinity partitioning, and affinity precipitation.
문학적 Text와 드라마치료와의 접점 : 비블리오드라마 (2010)

본 논문은 문학적 텍스트와 드라마치료가 만난 치료 및 교육양식이라 할 수 있는 비블리오드라마를 노인들을 대상으로 한 임종준비프로그램인 웰 다잉(Well dying) 프로그램으로 진행했을 때 어떤 효과가 있을 것인가를 탐색해 보는 데 그 목적이 있다.
 그 결과 다음과 같은 결론을 얻을 수 있었다.
 1. 프로그램 실시 후 거의 모든 참여자의 우울감...
Anticancer Activities of Protopanaxadiol‐ and Protopanaxatriol‐Type Ginsenosides and Their Metabolites (2016)

Recently, most anticancer drugs are derived from natural resources such as marine, microbial, and botanical sources, but the low success rates of chemotherapies and the development of multidrug resistance emphasize the importance of discovering new compounds that are both safe and effective against cancer. Ginseng types, including Asian ginseng, American ginseng, and notoginseng, have been used traditionally to treat various diseases, due to their immunomodulatory, neuroprotective, antioxidative, and antitumor activities. Accumulating reports have shown that ginsenosides, the major active component of ginseng, were helpful for tumor treatment. 20(S)-Protopanaxadiol (PDS) and 20(S)-protopanaxatriol saponins (PTS) are two characteristic types of triterpenoid saponins in ginsenosides. PTS holds capacity to interfere with crucial metabolism, while PDS could affect cell cycle distribution and prodeath signaling. This review aims at providing an overview of PTS and PDS, as well as their metabolites, regarding their different anticancer effects with the proposal that these compounds might be potent additions to the current chemotherapeutic strategy against cancer.
Ostwald ripening of end-of-range defects in silicon (1998)

End-of-range (EOR) defects are interstitial type dislocation loops which nucleate just beneath the crystalline/amorphous (c/a) interface formed by ion implantation in Si, after the preamorphization of the substrate, and during the ramping-up of the anneal. They originate from the presence of a high supersaturation of “excess” Si self-interstitial atoms located just beneath the c/a interface. Upon annealing, the mean radius of the defects increases while their density decreases through the exchange of Si self-interstitial atoms between the loops. The number of interstitials stored in the loops stays constant. For sufficiently high thermal budgets, when the nucleation is finished, and when the local equilibrium between extended and point defects is established, the coarsening of the EOR defects can be modeled through the Ostwald ripening theory applied to the dislocation loops geometry. Indeed, and as expected from the theory, the square of the mean radius of the loop population increases with time while the loop density decreases proportional to 1/t. Furthermore, the theoretical function describing the size distributions perfectly matches the time evolution of the experimental stack histograms, for different annealing temperatures. During the asymptotic steady-state coarsening regime, the activation energy for the loop coarsening is 4.4 eV, which is in the range of values given in the literature for self-diffusion in Si. Nevertheless, an activation energy of about 1–2 eV is found during the transient period preceding the local equilibrium, i.e., in the range of the migration energy of self-interstitials. The limiting phenomenon for the loop growth appears to be diffusion, since it is the hypothesis that leads to the best fit between theory and experiment. An estimate of DiCi* has been derived from the growth laws of the EOR defects. A value of about 1.8×107 cm−1 s−1 at 1000 °C is obtained and compares well with the values given in the literature.
Pravastatin for the Prevention of Preeclampsia in High-risk Pregnant Women (2014)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious Issues Collections Obstetric Airway ManagementMaternal EmbolismRegional Anesthesia for Cesarean SectionGeneral Anesthesia for Cesarean SectionAnalgesia for LaborObstetric HemorrhagePre-Eclampsia/EclampsiaPharmacologyTraumaInfection and SepsisMaternal ObesityMaternl Morbidity and MortalityNeonatal Morbidity and MortalityObstetric ComplicationsAnesthetic ComplicationsNon-Obstetric Maternal DiseaseCritical CareDrug Abuse in PregnancyEthicsSystems Based Practice For Authors Information for AuthorsLanguage Editing Services Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
A Fluorescence Study of the Adsorption of Water, Methanol, and Acetic Acid on an Activated Europium Ion-exchanged Mordenite (1984)

Abstract The adsorption of water, methanol, and acetic acid on an activated Eu(III) ion-exchanged mordenite(Eu–M) has been studied by the measurement of the fluorescence of the Eu2+ ion which was produced by the dehydration at 500 °C. The emission peak of the Eu2+ ion sifted to a shorter wavelength on exposure to water and other simple molecules. The magnitude of the shift was correlated to the specific dielectric constant of the adsorbate. The quantum yield for the Eu2+ emission band after gas adsorption decreased in all cases. Also, the lifetime in the Eu2+-adsorbate system was shorter than that in an activated Eu–M sample. The rate constants for the radiationless transitions were more sensitive to the nature of the adsorbates, and the order of the quenching power was H2O&gt;D2O&gt;CH3OH.
Gateways to overcome incompatibilities of security mechanisms (2003)

We describe the use of security gateways to overcome incompatibilities and configuration differences between acting parties participating in distributed applications. We present different variants and discuss their relative advantages in different scenarios considering possible attacks, performance and ease of use.
Prospects for metal/non-metal microsystems: sensors, sources and switches (1992)

Abstract For many purposes the requirements of device miniaturization present a great challenge. Here, the fields of microsensors, microsources of electrons and photons, and non-conventional microelectronic devices, e.g. switches, memory elements and molecular electronics, will be traced and discussed by a few examples.
MFCA-based simulation analysis for environment-oriented scm optimization conducted by SMEs (2012)

The environmental and economic benefits of Small and Medium Sized Enterprises (SMEs) are rarely considered during supply chain optimization. In this study, using the concept of Material Flow Cost Accounting (MFCA), an AS-IS simulation model for the supply chain comprising a Japanese gear manufacturing SME and its customer was constructed to visualize the enormous amount of waste generated by the production process. A TO-BE simulation model for the process innovation plan conducted by the above SME confirmed that the reduction in the machinery allowance and in the production lead time of the entire supply chain could be achieved, which will provide environmental and economic benefits to the entire supply chain.
Neither desferrioxamine nor lipoic acid enhances the cold ischaemic tolerance of epigastric free flaps in rats (1993)

Abstract This study was designed to test the ability of pre‐ and postischaemic administration of desferrioxamine (DFX), a combination of a preischaemic single passage perfusion with hypertonic citrate solution (HCA) and postischaemic administration of DFX, and pre‐ and postischaemic administration of lipoic acid (LA) to enhance the cold (0°C) ischaemia tolerance in epigastric free flaps in inbred rats. The ischaemic intervals varied between 0 and 120 hr. The area of flap survival 2 weeks after revascularisation as a percentage of original flap size was recorded as an exponent of ischaemic tolerance. None of the treatment regimens was able to increase flap area survival. Histologically, there were no major differences between the different treatment regimens. © 1993 Wiley‐Liss Inc.
Effect of Polyethylene Glycol, Alkyl, and Oligonucleotide Spacers on the Binding, Secondary Structure, and Self-Assembly of Fractalkine Binding FKN-S2 Aptamer-Amphiphiles (2014)

Previously we identified an aptamer, named FKN-S2, which binds the cell surface protein fractalkine with high affinity and specificity. In this paper a hydrophobic dialkyl C16 tail was added to the aptamer to create an aptamer-amphiphile. We investigated how the tail and a spacer molecule of varying length and hydrophobicity, inserted between the tail and the aptamer headgroup, affect the binding, structure, and self-assembly properties of the aptamer-amphiphile. We synthesized aptamer-amphiphiles with no spacer (NoSPR), polyethylene glycol (PEG4, PEG8, PEG24), alkyl (C12 and C24), or oligonucleotide (T10 and T5: 10 and 5 thymine, and A10: 10 adenine) spacers. The addition of the tail reduced the binding affinity of the aptamer-amphiphile over 7.5-fold compared to the free aptamer. The hydrophobic alkyl spacers resulted in the greatest loss of affinity, and the hydrophilic PEG spacers improved amphiphile affinity but did not restore it to that of the free aptamer. Interestingly, oligonucleotide spacers produced the highest affinity amphiphiles. Nucleotide composition did not affect affinity, however, as the T10 and A10 spacers had equal affinity. The oligonucleotide spacer amphiphiles had the highest affinity because the oligonucleotide spacer increased the affinity of free aptamer; the FKN-S2 aptamer plus the oligonucleotide spacer had a higher affinity than the free FKN-S2 aptamer. Circular dichroism (CD) spectroscopy and thermal melting studies indicated the aptamer forms a stem-loop and intramolecular G-quadruplex, and the tail strongly stabilized the formation of the G-quadruplex in a buffer. Cryogenic transmission electron microscopy (cryo-TEM) imaging showed the aptamer-amphiphiles, independent of the spacer used, self-assembled into micelles and nanotapes, flat bilayer structures that were often twisted. Finally, liposomes functionalized with the FKN-S2 amphiphile were incubated with fractalkine expressing cells, and the amount of binding was dependent on the concentration of the amphiphile on the liposome surface.
The effect of 30 Hz vs. 50 Hz passive vibration and duration of vibration on skin blood flow in the arm. (2008)

Five minutes of 30 Hz or 50 Hz vibration produced significant increases in SBF. Clinically, 50 Hz has additional benefits because SBF increased more rapidly and did not result in vasoconstriction during the recovery period. Future studies should be done to determine if these increases in SBF could be of benefit to populations with low circulation such as those with diabetes.