gebhart/patrepeval huggingface dataset:
Infrared neural stimulation of human spinal nerve roots<i>in vivo</i> (2015)

Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise neural activity with a noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study is to demonstrate the safety and efficacy of INS in humans in vivo. The feasibility of INS in humans was assessed in patients ([Formula: see text]) undergoing selective dorsal root rhizotomy, where hyperactive dorsal roots, identified for transection, were stimulated in vivo with INS on two to three sites per nerve with electromyogram recordings acquired throughout the stimulation. The stimulated dorsal root was removed and histology was performed to determine thermal damage thresholds of INS. Threshold activation of human dorsal rootlets occurred in 63% of nerves for radiant exposures between 0.53 and [Formula: see text]. In all cases, only one or two monitored muscle groups were activated from INS stimulation of a hyperactive spinal root identified by electrical stimulation. Thermal damage was first noted at [Formula: see text] and a [Formula: see text] safety ratio was identified. These findings demonstrate the success of INS as a fresh approach for activating human nerves in vivo and providing the necessary safety data needed to pursue clinically driven therapeutic and diagnostic applications of INS in humans.
Conformational Flexibility in Respiratory Syncytial Virus G Neutralizing Epitopes (2019)

Respiratory syncytial virus (RSV) is a top cause of severe lower respiratory tract disease and mortality in infants and the elderly. Currently, no vaccine or effective treatment exists for RSV. The RSV G glycoprotein mediates viral attachment to cells and contributes to pathogenesis by modulating host immunity through interactions with the human chemokine receptor CX3CR1. Antibodies targeting the RSV G central conserved domain are protective in both prophylactic and postinfection animal models. Here, we describe the crystal structure of the broadly neutralizing human monoclonal antibody 3G12 bound to the RSV G central conserved domain. Antibody 3G12 binds to a conformational epitope composed of highly conserved residues, explaining its broad neutralization activity. Surprisingly, RSV G complexed with 3G12 adopts a distinct conformation not observed in previously described RSV G-antibody structures. Comparison to other structures reveals that the RSV G central conserved domain is flexible and can adopt multiple conformations in the regions flanking the cysteine noose. We also show that restriction of RSV G flexibility with a proline mutation abolishes binding to antibody 3G12 but not antibody 3D3, which recognizes a different conformation of RSV G. Our studies provide new insights for rational vaccine design, indicating the importance of preserving both the global structural integrity of antigens and local conformational flexibility at antigenic sites, which may elicit a more diverse antibody response and broader protection against infection and disease.<b>IMPORTANCE</b> Respiratory syncytial virus (RSV) causes severe respiratory infections in infants, young children, and the elderly, and currently, no licensed vaccine exists. In this study, we describe the crystal structure of the RSV surface glycoprotein G in complex with a broadly neutralizing human monoclonal antibody. The antibody binds to RSV G at a highly conserved region stabilized by two disulfide bonds, but it captures RSV G in a conformation not previously observed, revealing that this region is both structured and flexible. Importantly, our findings provide insight for the design of vaccines that elicit diverse antibodies, which may provide broad protection from infection and disease.
Glycoprotein Targeted CAR-NK Cells for the Treatment of SARS-CoV-2 Infection (2021)

H84T-Banana Lectin (BanLec) CAR-NK cells bind high mannose glycosites that decorate the SARS-CoV-2 envelope, thereby decreasing cellular infection in a model of SARS-CoV-2. H84T-BanLec CAR-NK cells are innate effector cells, activated by virus. This novel cellular agent is a promising therapeutic, capable of clearing circulating SARS-CoV-2 virus and infected cells. Banana Lectin (BanLec) binds high mannose glycans on viral envelopes, exerting an anti-viral effect. A point mutation (H84T) divorces BanLec mitogenicity from antiviral activity. SARS-CoV-2 contains high mannose glycosites in proximity to the receptor binding domain of the envelope Spike (S) protein. We designed a chimeric antigen receptor (CAR) that incorporates H84T-BanLec as the extracellular moiety. Our H84T-BanLec CAR was devised to specifically direct NK cell binding of SARS-CoV-2 envelope glycosites to promote viral clearance. The H84T-BanLec CAR was stably expressed at high density on primary human NK cells during two weeks of ex vivo expansion. H84T-BanLec CAR-NK cells reduced S-protein pseudotyped lentiviral infection of 293T cells expressing ACE2, the receptor for SARS-CoV-2. NK cells were activated to secrete inflammatory cytokines when in culture with virally infected cells. H84T-BanLec CAR-NK cells are a promising cell therapy for further testing against wild-type SARS-CoV-2 virus in models of SARS-CoV-2 infection. They may represent a viable off-the-shelf immunotherapy for patients suffering from COVID-19.
Techniques for respiration-induced artifacts reductions in thoracic PET/CT. (2012)

The advent of positron emission tomography/computed tomography (PET/CT) provides fusion of both anatomical and functional information. CT-based attenuation correction replaced (68)Ge-based attenuation correction for shortening acquisition time, improving image quality and quantitative accuracy. However, due to the temporal difference of PET and CT, mis-registration and motion artifacts are observed in the attenuation-corrected images mainly due to the respiratory motion. Reducing the spatial mismatch of the PET and CT reconstructed image remains a challenge. This review provides an introduction to various respiratory image artifacts reduction techniques especially for thoracic lesions, including breathing instruction based methods, CT protocol based methods and 4-dimensional PET/CT. The advantages and drawbacks of different methods are also discussed.
Relationship Between Combined Histologic and Endoscopic Endpoints and Efficacy of Ustekinumab Treatment in Patients With Ulcerative Colitis (2020)

Data from the UNIFI program of ustekinumab in patients with UC treated with ustekinumab indicated the achievement of histo-endoscopic mucosal healing after induction therapy is associated with lower disease activity at the end of maintenance therapy than either histologic or endoscopic improvement alone. ClinicalTrials.gov number: NCT02407236.
Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study (2020)

COVID-19-ARDS is a subset of ARDS characterized overall by higher compliance and lung gas volume for a given PaO<sub>2</sub>/FiO<sub>2</sub>, at least when considered within the timeframe of our study.
Adaptive Modulation Scheme Based on Partially Pre-Distorted LACO-OFDM for VLC System (2019)

In this paper, an adaptive modulation scheme for visible light communication (VLC) system based on partially pre-distorted layered asymmetrically clipped optical orthogonal frequency division multiplexing (LACO-OFDM) is proposed. The clipping noise that falls on the higher layers in the conventional LACO-OFDM results in inter layer interference, which can be eliminated by the operation of pre-distortion at the expense of extra power consumption. The proposed partially pre-distorted scheme makes a tradeoff between error propagation and power cost to suit different transmission environments. The probability distribution functions of the conventional and pre-distorted LACO-OFDM schemes are analyzed and compared and the layers that should be pre-distorted in the proposed scheme is decided adaptively by maximizing the achievable rate. The computational complexity of the proposed scheme is also investigated, which is acceptable compared with the previous schemes. Simulation results show that the proposed scheme has a superior bit error rate performance compared with the conventional and pre-distorted LACO-OFDM schemes.
Direct Patterning of Poly(<i>p</i>-phenylene vinylene) Thin Films Using Microcontact Printing (2003)

This Letter describes a convenient means of direct patterning of conjugated polymers on solid substrates by microcontact printing. An amine-containing poly(p-phenylene vinylene) (PPV) was synthesized and printed onto the surface with the SAMs terminating in interchain carboxylic anhydrides. Well-defined PPV micropatterns were characterized by atomic force microscopy and fluorescence microscopy. The interaction between the polymer thin films and the surface was analyzed by grazing angle infrared spectroscopy, X-ray photoelectron spectroscopy, and cyclic voltammetry. The formation of covalent bonds via amidation renders great stability of the resulting functional patterns.
Cardiac MPI of mice over the complete heart cycle (2009)

Magnetic Particle Imaging (MPI) allows rapid imaging of magnetic tracer distributions with high sensitivity. We show volumetric in vivo heart images of a mouse. The concentration of the commercially available MR contrast agent was in a range which is approved for humans. Images at various stages of the cardiac cycle were reconstructed proving the unprecedented temporal resolution of MPI. The results suggest that MPI can be scaled up to human sized scanners enabling, e.g., dynamic imaging of coronary blood flow.
Bulldozer: A Cooperative P2P-Based Distribution Platform for User-Centric Content Dissemination (2011)

Because of marketing demand of user-centric video dissemination, promoting video content via interactive distribution platforms has received considerable attention recently. In addition, the preferences of clients are heterogenous and dynamic, effectively utilizing the network bandwidth to distribute user-centric content becomes a challenging problem, especially when the number of users in the systems scale up. Therefore, we propose a P2P-based distribution platform, called Bulldozer, which enable clients to cooperatively propagate user-centric video content in a large scale environment, and better utilizes peers upload bandwidth to share the server traffic load. Bulldozer consists of two components: 1) Clip Scheduling phase schedules the playing order of videos for each individual user, and 2) Bandwidth Allocation phase allocates users upload bandwidths to distribute videos among clients. Finally, simulation results show that Bulldozer can effectively reduce the peak traffic load of the server.
Glyco-S-nitrosothiols, a novel class of no donor compounds (1996)

Three novel glyco-S-nitrosothiol NO donor compounds 1, 2, and 3 have been synthesized. These compounds outperform S-nitroso-N-acetylpenicillamine (SNAP) in aqueous solubility and stability, with and without EDTA and in the presence or absence of Cu2+.
Parallel feed travelling wave distributed<b><i>pin</i></b>photodetectors with integrated MMI couplers (2002)

The fabrication and performance of a parallel feed travelling wave photodetector with pin diodes operating at 1550 nm is presented. A parallel optical feed using an integrated multimode interference (MMI) power splitter helps increase the maximum linear photocurrent through a more uniform distribution of photocurrent. The maximum DC linear current measured is 52.2 mA. Maximum linear RF power at 10 GHz was 9 dBm.
Physics of Shock Waves and High-Temperature Hydrodynamic Phenomena (2002)

Abstract : Contents: Elements of gas dynamics and classical theory of shock waves; thermal radiation and radiant heat exchange in a medium; thermodynamic properties of gases at high temperatures; shock tubes; absorption and emission of radiation in gases at high temperatures; speed of relaxation processes in gases; structure of front of shock waves in gases; physico-chemical kinetics in hydrodynamic processes; light phenomena in shock waves and during strong explosion in air; thermal waves; shock waves in solids; certain self-similar processes in gas dynamics.
Alcance temporal y dimensión normativa del nuevo criterio de competencia territorial para el exequátur en la Ley de cooperación jurídica internacional: Perspectiva jurisprudencial (2016)

espanolEl presente trabajo examina el nuevo criterio de competencia territorial del juez espanol en procedimientos de exequatur introducido por el art. 52.1 in fine de la Ley de cooperacion juridica internacional en materia civil y mercantil y su posible aplicacion retroactiva a solicitudes presentadas con anterioridad a la entrada en vigor de dicha ley. Las dudas que la aplicacion de este foro ha suscitado en nuestra jurisprudencia, asi como su potencial vinculacion con el art. 22 octies 3 II de la Ley Organica del Poder Judicial, nos ha llevado asimismo a precisar el significado de este foro en el nuevo contexto normativo. EnglishThe present paper examines the new criterion of territorial jurisdiction of Spanish Judge in exquatur procedures introduced by the art. 52.1 in fine of the Law of international legal cooperation in civil and commercial matters and its potential retroactive application to requests submitted prior to the entry into force of this law. The doubts that the implementation of this forum has given rise in our jurisprudence, as well as their potential link with the art. 22 g 3 II of the Organic Law of the Judiciary, has also led us to clarify the meaning of this forum in the new regulatory context.
Grid Connected Fuel Cell Based Distributed Power Generation System (2017)

Fuel cell based power generation is emphasized due to its capability of supplying electricity in the areas where there are hardly any source of conventional or non-conventional power generating options to adopt. Moreover, the added advantage is that it can be used during peak loads. Fuel cell based power generation is well known due to its clean operation, transportability, suitability and flexibility for power generation. This paper gives the outlook of modeling of a fuel cell power generation system, a multilevel inverter and their control algorithms. The design system is used in isolated loads as well as grid connected system. Different carrier signals have been used with two different modulating signals for multilevel inverter for lowest Total Harmonic Distortion (THD) in the output using seven levels and eleven level inverters. The inverter output is fed to consumer loads. The MATLAB/SIMULINK software is used for modeling this system. The developed fuel cell based distributed power generation system worked satisfactorily, when it is connected to grid and used in isolated mode or hybrid mode.
Avian Nephritis Virus Infection of Chicks: Virology, Pathology, and Serology (1990)

Avian nephritis virus (ANV), G-4260 strain, was inoculated orally into 1-day-old specific-pathogen-free chicks of the line 15I for virological, pathological, and serological study of the ANV infection of chicks. The virus titer and incidence of appearance of fluorescent antigens in the kidneys were highest at 4 days postinoculation (PI) and decreased gradually. The degeneration of proximal tubules was the principal pathological change in kidneys of chicks at 4 days PI, and interstitial nephritis was the principal pathological change in kidneys of chicks from 6 to 14 days PI. Moreover, gouty nodules were apparent in the kidneys of more than half of the chicks at 10 days PI. The plasma urate value of infected chicks was clearly higher than that of control chicks, reaching a maximum at 10 days PI, then gradually decreasing. The serum antibody was detected from 4 days PI and increased gradually. The chicks affected with visceral urate deposits or urate deposits in the digitated joints showed high plasma urate values (more than 100 mg/dl).
Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors (2022)

DuoBody-PD-L1×4-1BB (GEN1046) is a first-in-class bispecific immunotherapy with a manageable safety profile and encouraging preclinical and early clinical activity. With its ability to confer clinical benefit in tumors typically less sensitive to CPIs, GEN1046 may fill a clinical gap in CPI-relapsed or refractory disease or as a combination therapy with CPIs. See related commentary by Li et al., p. 1184. This article is highlighted in the In This Issue feature, p. 1171.
Early recovery after fast-track Oxford unicompartmental knee arthroplasty (2012)

Fast-track MIS Oxford UKA with discharge on the day after surgery is safe and leads to early recovery of knee motion and strength even when no physiotherapy is used.
Comparison of Piezoelectric Energy Harvesting Devices for Recharging Batteries (2005)

Piezoelectric materials can be used as a means of transforming ambient vibrations into electrical energy that can then be stored and used to power other devices. With the recent surge of microscale devices, piezoelectric power generation can provide a convenient alternative to traditional power sources used to operate certain types of sensors/actuators, telemetry, and MEMS devices. However, the energy produced by these materials is in many cases far too small to directly power an electrical device. Therefore, much of the research into power harvesting has focused on methods of accumulating the energy until a sufficient amount is present, allowing the intended electronics to be powered. In a recent study by Sodano et al. (2004a) the ability to take the energy generated through the vibration of a piezoelectric material was shown to be capable of recharging a discharged nickel metal hydride battery. In the present study, three types of piezoelectric devices are investigated and experimentally tested to determine each of their abilities to transform ambient vibration into electrical energy and their capability to recharge a discharged battery. The three types of piezoelectric devices tested are the commonly used monolithic piezoceramic material lead–zirconate–titanate (PZT), the bimorph Quick Pack (QP) actuator, and the macro-fiber composite (MFC). The experimental results estimate the efficiency of the three devices tested and identify the feasibility of their use in practical applications. Different capacity batteries are recharged using each device, to determine the charge time and maximum capacity battery that can be charged. The results presented in this article provide a means of choosing the piezoelectric device to be used and estimate the amount of time required to recharge a specific capacity battery.
Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer (2014)

In 1882, Robert Koch suggested four postulates that establish causation between an infectious agent and a particular disease: (1) the infectious organism must be found in abundance in all diseased, but not in healthy, organisms, (2) the infectious organism must be isolated from the diseased host and grown in culture, (3) the disease must be reproduced when the cultured organism is introduced into a healthy organism and (4) the same organism must be reisolated from the experimentally diseased host In Figure In the following sections we describe the prevalence of P. aeruginosa in cancer and the immunosuppressive and stress-inducing conditions of cancer that facilitate the growth, dissemination and virulence of intestinal P. aeruginosa. In addition, we describe work showing that P. aeruginosa promotes intestinal epithelium cancer-related phenotypes when introduced in tumor prone model hosts.
Self-injected neodymium-yttrium aluminum garnet laser with an unstable cavity (1982)

The first ’’self-injected’’ unstable resonator laser is reported. 1-ns, high peak power, single-mode pulses are generated with neodymium-yttrium aluminum garnet (Nd-YAG) laser made with the same relevant optical components of the commercial DCR1 Quanta Ray oscillator.
A Clostridium Group IV Species Dominates and Suppresses a Mixed Culture Fermentation by Tolerance to Medium Chain Fatty Acids Products (2017)

A microbial community is engaged in a complex economy of cooperation and competition for carbon and energy. In engineered systems such as anaerobic digestion and fermentation, these relationships are exploited for conversion of a broad range of substrates into products, such as biogas, ethanol, and carboxylic acids. Medium chain fatty acids (MCFAs), for example, hexanoic acid, are valuable, energy dense microbial fermentation products, however, MCFA tend to exhibit microbial toxicity to a broad range of microorganisms at low concentrations. Here, we operated continuous mixed population MCFA fermentations on biorefinery thin stillage to investigate the community response associated with the production and toxicity of MCFA. In this study, an uncultured species from the <i>Clostridium</i> group IV (related to <i>Clostridium</i> sp. BS-1) became enriched in two independent reactors that produced hexanoic acid (up to 8.1 g L<sup>-1</sup>), octanoic acid (up to 3.2 g L<sup>-1</sup>), and trace concentrations of decanoic acid. Decanoic acid is reported here for the first time as a possible product of a <i>Clostridium</i> group IV species. Other significant species in the community, <i>Lactobacillus</i> spp. and <i>Acetobacterium</i> sp., generate intermediates in MCFA production, and their collapse in relative abundance resulted in an overall production decrease. A strong correlation was present between the community composition and both the hexanoic acid concentration (<i>p</i> = 0.026) and total volatile fatty acid concentration (<i>p</i> = 0.003). MCFA suppressed species related to <i>Clostridium</i> sp. CPB-6 and <i>Lactobacillus</i> spp. to a greater extent than others. The proportion of the species related to <i>Clostridium</i> sp. BS-1 over <i>Clostridium</i> sp. CPB-6 had a strong correlation with the concentration of octanoic acid (<i>p</i> = 0.003). The dominance of this species and the increase in MCFA resulted in an overall toxic effect on the mixed community, most significantly on the <i>Lactobacillus</i> spp., which resulted in a decrease in total hexanoic acid concentration to 32 ± 2% below the steady-state average. As opposed to the current view of MCFA toxicity broadly leading to production collapse, this study demonstrates that varied tolerance to MCFA within the community can lead to the dominance of some species and the suppression of others, which can result in a decreased productivity of the fermentation.
A Fortran compiler for the FPS-164 scientific computer (1984)

article A Fortran compiler for the FPS-164 scientific computer Share on Author: Roy F. Touzeau Floating Point Systems, Inc., Beaverton, Oregon Floating Point Systems, Inc., Beaverton, OregonView Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 19Issue 6June 1984 pp 48–57https://doi.org/10.1145/502949.502879Online:01 June 1984Publication History 97citation332DownloadsMetricsTotal Citations97Total Downloads332Last 12 Months10Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access