gebhart/patrepeval huggingface dataset:
Role of Ca2+ in apoptosis evoked by human amylin in pancreatic islet beta-cells. (1999)

The objective of these studies was to clarify the role of Ca(2+) in the mechanism of death evoked by human amylin (hA) in islet beta-cells. hA forms fibrils in vitro and islet amyloid in vivo. Here we show that pure synthetic hA aggregated in solution, formed fibrils and evoked death in cultured RINm5F islet beta-cells in a time-dependent (0-24 h) and concentration-dependent (0-20 microM) manner. Dying cells underwent shrinkage of the nucleus, with clumping and segregation of chromatin into masses that lay against the nuclear envelope, and internucleosomal DNA fragmentation. These cells therefore show many features of apoptosis, although aspects of the morphology might be characteristic of this particular cell type rather than of a general apoptotic nature. Aurintricarboxylic acid, an inhibitor of both Ca(2+)-dependent and Ca(2+)-independent nucleases, suppressed this DNA fragmentation and inhibited apoptosis at concentrations between 25 and 200 microM. Direct measurements of the cytoplasmic free Ca(2+) concentration ([Ca(2+)](i)) in fura-2 acetoxymethyl ester (AM)-loaded beta-cells showed that neither hA nor its non-cytotoxic homologue, rat amylin were effective in raising [Ca(2+)](i). Modulators of Ca(2+) regulation were tested for their effects on hA-induced beta-cell apoptosis. Ca(2+) ionophore (A23187) and thapsigargin (an inhibitor of endoplasmic reticular Ca(2+)-ATPase activity) by themselves evoked apoptosis accompanied by increased [Ca(2+)](i). Neither the Ca(2+) channel blocker verapamil, the extracellular Ca(2+) chelator EGTA nor the cytosolic Ca(2+) buffer bis-(o-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid ('BAPTA')/AM protected beta-cells from hA-evoked apoptosis. Prolonged incubation of beta-cells with a lethal dose of hA altered neither the basal [Ca(2+)](i) nor the thapsigargin-induced release of Ca(2+) from intracellular stores. Furthermore, (45)CaCl(2) uptake by RINm5F cells did not differ in the presence or absence of hA. These results suggest that, whereas alterations in cytosolic Ca(2+) homoeostasis do have a significant role in certain forms of beta-cell death, they do not contribute to the pathway of apoptosis evoked by hA in islet beta-cells.
Paradigm Change in Integrative Care: Third-party Payment and the Cost-benefit … Plus More. (2018)

The business of integrative health and medicine poses 2 challenges at the intersection with the dominant school of medicine. One is that the medical industry—in the still prevailing fee-for-service context—benefits from an increase in production of costly surgeries, drugs, and procedures. Thus, it is perversely incented against integrative approaches and practitioners that may reduce needs for these services. (See “AMA’s Celebration of MDs’ Economic Muscle Exposes Barriers to Integrative Health” in the last issue of IMCJ.) The second challenge, paradoxically, is that concern from these same decision-makers about potential costs that may be incurred is a barrier to access and inclusion of integrative practitioners providing nonpharmacologic services. This issue of IMCJ Industry News provides 3 angles of perspective on these cost issues.
A single-ended-to-differential transimpedence amplifier for a voice transceiver analog interface (2006)

This target of the work is the replacing of a voltage amplifier with a here proposed transimpedance one in the voice transceiver analog interface, in order to simplify the structure avoiding the use of high cost external components. This target required the development of an innovative transimpedence architecture here presented: it operates a single-ended-to-differential current conversion, leading the circuit to operate as a fully differential transimpedance structure, improving signal immunity. The proposed device has been designed in a 0.13mum CMOS technology and operates from a single 1.5V supply voltage
Grasp2Vec: Learning Object Representations from Self-Supervised Grasping (2018)

Well structured visual representations can make robot learning faster and can improve generalization. In this paper, we study how we can acquire effective object-centric representations for robotic manipulation tasks without human labeling by using autonomous robot interaction with the environment. Such representation learning methods can benefit from continuous refinement of the representation as the robot collects more experience, allowing them to scale effectively without human intervention. Our representation learning approach is based on object persistence: when a robot removes an object from a scene, the representation of that scene should change according to the features of the object that was removed. We formulate an arithmetic relationship between feature vectors from this observation, and use it to learn a representation of scenes and objects that can then be used to identify object instances, localize them in the scene, and perform goal-directed grasping tasks where the robot must retrieve commanded objects from a bin. The same grasping procedure can also be used to automatically collect training data for our method, by recording images of scenes, grasping and removing an object, and recording the outcome. Our experiments demonstrate that this self-supervised approach for tasked grasping substantially outperforms direct reinforcement learning from images and prior representation learning methods.
A new face‐centered‐cubic photonic crystal for microwave and millimeter‐wave applications (1994)

Abstract Three‐dimensional photonic crystals are fabricated that consist of a face‐centered‐cubic lattice of air atoms embedded in a synthetic dielectric matrix. The crystals are formed by stacking triangular arrays of cylindrical atoms in a close‐packed arrangement. The fabrication technique is much simpler than previous methods and is well suited to producing photonic band gaps in the microwave and millimeter‐wave regions. Microwave measurements provide strong evidence for a photonic band gap between approximately 17 and 18 GHz in a crystal having a volumetric air fraction of 60%. © 1994 John Wiley & Sons, Inc.
The role of the eosinophil in nasal diseases (2005)

The data provides evidence regarding the pivotal role of the eosinophil in sino-nasal diseases. Possible ways to target the eosinophils are discussed.
Learning geographical preferences for point-of-interest recommendation (2013)

The problem of point of interest (POI) recommendation is to provide personalized recommendations of places of interests, such as restaurants, for mobile users. Due to its complexity and its connection to location based social networks (LBSNs), the decision process of a user choose a POI is complex and can be influenced by various factors, such as user preferences, geographical influences, and user mobility behaviors. While there are some studies on POI recommendations, it lacks of integrated analysis of the joint effect of multiple factors. To this end, in this paper, we propose a novel geographical probabilistic factor analysis framework which strategically takes various factors into consideration. Specifically, this framework allows to capture the geographical influences on a user's check-in behavior. Also, the user mobility behaviors can be effectively exploited in the recommendation model. Moreover, the recommendation model can effectively make use of user check-in count data as implicity user feedback for modeling user preferences. Finally, experimental results on real-world LBSNs data show that the proposed recommendation method outperforms state-of-the-art latent factor models with a significant margin.
Performance of an Alternative Ginning and Lint Cleaning System (1986)

ABSTRACT -Acomparison was made between an experimental combination gin-lint cleaner and a standard commercial gin stand and two lint cleaner system. Quality factors of cotton lint processed through the experimental system were equal to or better than cotton lint processed through the standard system. The experimental system has a good potential for reducing the capital and operating costs of lint cleaning systems because of fewer component parts and lower operating energy requirements.
Enhanced near room temperature magnetocaloric effect in La<sub>0.6</sub>Ca<sub>0.4</sub>MnO<sub>3</sub> for magnetic refrigeration application (2017)

Perovskite manganite La<sub>0.6</sub>Ca<sub>0.4</sub>MnO<sub>3</sub> (LCMO) nanomaterials were synthesized by a modified Pechini sol–gel process followed by high temperature sintering.
Clausal Form Logic: An Introduction to the Logic of Computer Reasoning (1989)

From the Publisher:
This unique book provides a gentle introduction to an increasingly important type of formal logic called CLAUSAL FORM LOGIC (CFL). Having evolved out of human reasoning, CFL represents the ideal to which all computer-based systems must approximate. Most present day computational logic systems are based on it, including the well-know artificial intelligence language PROLOG.
Surface Chemistry on Colloidal Metals. Reversible Adsorbate-Induced Surface Composition Changes in Colloidal Palladium-Copper Alloys (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface Chemistry on Colloidal Metals. Reversible Adsorbate-Induced Surface Composition Changes in Colloidal Palladium-Copper AlloysJohn S. Bradley, Ernestine W. Hill, Bruno Chaudret, and Anne DuteilCite this: Langmuir 1995, 11, 3, 693–695Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/la00003a002https://doi.org/10.1021/la00003a002research-articleACS PublicationsRequest reuse permissionsArticle Views429Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Semiconductor Gas Sensors: Dry Synthesis and Application (2010)

Since the development of the first chemoresistive metal oxide based gas sensors, transducers with innovative properties have been prepared by a variety of wet- and dry-deposition methods. Among these, direct assembly of nanostructured films from the gas phase promises simple fabrication and control and with the appropriate synthesis and deposition methods nm to μm thick films, can be prepared. Dense structures are achieved by tuning chemical or vapor deposition methods whereas particulate films are obtained by deposition of airborne, mono- or polydisperse, aggregated or agglomerated nanoparticles. Innovative materials in non-equilibrium or sub-stoichiometric states are captured by rapid cooling during their synthesis. This Review presents some of the most common chemical and vapor-deposition methods for the synthesis of semiconductor metal oxide based detectors for chemical gas sensors. In addition, the synthesis of highly porous films by novel aerosol methods is discussed. A direct comparison of structural and chemical properties with sensing performance is given.
Can’t Look Away: An Eye-Tracking Based Attentional Disengagement Training for Depression (2016)

To address shortcomings of purely reaction-time based attentional bias modification (ABM) paradigms, we developed an ABM task that is controlled by eye-tracking. This task allows to assess and train both disengagement from negative pictures and maintained attention to positive pictures. As a proof-of-principle study with an unselected student sample, this positive training (PT; N = 44) was compared to a negative training (NT; N = 42), which reinforced the opposite attentional pattern. Importantly, training trials were completed only if participants performed the correct gaze patterns. Results showed that higher depression levels were associated with slower disengagement from negative stimuli at baseline. As expected, the PT induced longer fixations on positive pictures and faster disengagement from negative pictures. The NT showed no changes in attentional processes. The groups did not differ in mood reactivity and recovery from a stressor. Advantages of using eye-tracking in ABM and potential applications of the training are discussed.
Human CRM1 Augments Production of Infectious Human and Feline Immunodeficiency Viruses from Murine Cells (2012)

Productive replication of human immunodeficiency virus type 1 (HIV-1) occurs efficiently only in humans. The posttranscriptional stages of the HIV-1 life cycle proceed poorly in mouse cells, with a resulting defect in viral assembly and release. Previous work has shown that the presence of human chromosome 2 increases HIV-1 production in mouse cells. Recent studies have shown that human chromosome region maintenance 1 (hCRM1) stimulates Gag release from rodent cells. Here we report that expressions of hCRM1 in murine cells resulted in marked increases in the production of infectious HIV-1 and feline immunodeficiency virus (FIV). HIV-1 production was also increased by hSRp40, and a combination of hCRM1 and hSRp40 resulted in a more-than-additive effect on HIV-1 release. In contrast, the overexpression of mouse CRM1 (mCRM1) minimally affected HIV-1 and FIV production and did not antagonize hCRM1. In the presence of hCRM1 there were large increases in the amounts of released capsid, which paralleled the increases in the infectious titers. Consistent with this finding, the ratios of unspliced to spliced HIV-1 mRNAs in mouse cells expressing hCRM1 and SRp40 became similar to those of human cells. Furthermore, imaging of intron-containing FIV RNA showed that hCRM1 increased RNA export to the cytoplasm.By testing chimeras between mCRM1 and hCRM1 and comparing those sequences to feline CRM1, we mapped the functional domain to HEAT (Huntingtin, elongation factor 3, protein phosphatase 2A, and the yeast kinase TOR1) repeats 4A to 9A and a triple point mutant in repeat 9A, which showed a loss of function. Structural analysis suggested that this region of hCRM1 may serve as a binding site for viral or cellular factors to facilitate lentiviral RNA nuclear export.
Photostrictive effect in (Pb, La) (Zr, Ti)O3 (1985)

Photostriction explainable by the superposition of the bulk photovoltaic effect and piezoelectricity has been investigated intensively in the solid solution ceramics (Pb, La) (Zr, Ti)O3 from an applicational point of view. Three key points are described for improving response speed of the photostriction; composition selection, device designing, and driving and controlling technique.
Improving computation of cardiovascular relative pressure fields from velocity MRI (2009)

Popular iterative approaches with quasirectangular computational domains can lead to significant systematic underestimation of the pressure amplitude. We suggest using a multigrid-based PPE solver with Galerkin coarsening, which works directly on the structure-defined computational domain. This solver provides accurate estimates of the relative pressure fields for both simple and complex geometries with additional significant improvements with respect to execution speed.
Costs Associated With Non-Residential Electric Vehicle Supply Equipment: Factors to consider in the implementation of electric vehicle charging stations (2015)

This document is designed to help employers, business owners, and fleet operators understand the costs associated with installing, operating, and maintaining electric vehicle supply equipment (EVSE), also known as electric vehicle “charging stations.” It provides an overview of the equipment and processes needed to install EVSE and offers representative examples of cost ranges. The information presented is based on data collected from various studies around the country, as well as input from EVSE owners, manufacturers, installers, and utilities. Many plug-in electric vehicle (PEV) drivers charge their vehicles at home using residential charging located at single family homes or multi-family complexes such as apartments and condominiums. This report however, focuses on the costs of non-residential stations such as public access, workplace, and fleet stations. Increasing the number of EVSE available in these nonresidential locations can help expand the electric driving range for PEVs, as well as enable PEV ownership for drivers without access to home charging.
Potential of a Novel Protein, OMP26, from Nontypeable <i>Haemophilus influenzae</i> To Enhance Pulmonary Clearance in a Rat Model (1998)

A major outer membrane protein band of approximately 25 to 27 kDa is commonly observed in strains of Haemophilus influenzae. This study has investigated the potential of a 26-kDa protein (OMP26) from nontypeable H. influenzae (NTHI) as a vaccine candidate. OMP26 was used to immunize rats via intestinal Peyer's patches, followed by an intratracheal boost. Immunization was found to significantly enhance bacterial clearance following pulmonary challenge with both the homologous NTHI strain and a different NTHI strain. Significant levels of anti-OMP26 were found in the serum and bronchoalveolar lavage from immunized rats, and isotypes of immunoglobulin G (IgG) were also measured in serum. Analysis of IgG isotypes present in serum following OMP26-immunization suggest that predominantly a T-helper 1-type response was induced. The OMP26 protein was amino-terminally sequenced and found to have no homology with the P5 of H. influenzae type b P5 or the fimbrin protein of NTHI, both can migrate upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis at similar molecular masses but OMP26 has 100% homology with a segment of the H. influenzae Rd genome. The results of this study suggest that OMP26 may be a suitable vaccine candidate against NTHI infection and warrants continued investigation and characterization.
Design and analysis of an FPGA-based, multi-processor HW-SW system for SCC applications (2010)

The last 30 years have seen an increase in the complexity of embedded systems from a collection of simple circuits to systems consisting of multiple processors managing a wide variety of devices. This ever increasing complexity frequently requires that high assurance, fail-safe and secure design techniques be applied to protect against possible failures and breaches. To facilitate the implementation of these embedded systems in an efficient way, the FPGA industry recently created new families of devices. New features added to these devices include anti-tamper monitoring, bit stream encryption, and optimized routing architectures for physical and functional logic partition isolation. These devices have high capacities and are capable of implementing processors using their reprogrammable logic structures. This allows for an unprecedented level of hardware and software interaction within a single FPGA chip. High assurance and fail-safe systems can now be implemented within the reconfigurable hardware fabric of an FPGA, enabling these systems to maintain flexibility and achieve high performance while providing a high level of data security. The objective of this thesis was to design and analyze an FPGA-based system containing two isolated, softcore Nios processors that share data through two crypto-engines. FPGA-based single-chip cryptographic (SCC) techniques were employed to ensure proper component isolation when the design is placed on a device supporting the appropriate security primitives. Each crypto-engine is an implementation of the Advanced Encryption Standard (AES), operating in Galois/Counter Mode (GCM) for both encryption and authentication. The features of the microprocessors and architectures of the AES crypto-engines were varied with the goal of determining combinations which best target high performance, minimal hardware usage, or a combination of the two.
Failure Mechanism of Solid Tantalum Capacitors (1976)

It has been suggested that failure of solid tantalum capacitors is due to thermal migration of impurities from the tantalum anode to flaws in the oxide layer. This implies, however, that leakage current gradually increases under normal operating conditions, an effect which has not been observed. An alternative hypothesis advanced here is that failure is due to crystallization of tantalum oxide under the influence of the electric field. Scanning electron microscopy of specially cleaned anodized tantalum sheet on which thin gold electrodes have been deposited clearly shows the occurrence of crystallization after 17 hours at an applied voltage of 75 V and a temperature of 65℃. Results of accelerated life tests on solid tantalum capacitors at temperatures of 85℃ and 125℃, and at up to 2,5 times rated voltage also accord better with a field crystallization hypothesis than with a thermal migration failure hypothesis.
Cerebrovascular Reactivity to Carbon Dioxide in Alzheimer's Disease (2013)

There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVRCO2) is impaired in Alzheimer's disease (AD). Preclinical and animal studies suggest chronic hypercontractility in brain vessels in AD. We review (a) preclinical studies of mechanisms for impaired CVRCO2 in AD; (b) clinical studies of cerebrovascular function in subjects with AD dementia, mild cognitive impairment (MCI), and normal cognition. Although results of clinical studies are inconclusive, an increasing number of reports reveal an impairment of vascular reactivity to carbon dioxide in subjects with AD, and possibly also in MCI. Thus, CVRCO2 may be an attractive means to detect an early vascular dysfunction in subjects at risk.
Semi-Automatic Landmark Detection in Digital X-Ray Images of the Spine (2002)

Quantitative diagnosis of 3D scoliotic deformities depends on a number of dedicated measurements. Existing methods rely on the manual determination of a series of anatomical landmarks in X-ray images. We have developed an automatic method to alleviate the burden of this tedious task. Our method looks for a compromise between local image information and global prior constraints and finds the most probable points using dynamic programming optimization. Remaining errors can be quickly corrected by effective user interaction. The first results are promising.
Coupled-mode formulations (1989)

Vector coupled-mode theory is extended beyond the conventional first-order treatment. Good results are obtained from the extended theory in the case of waveguides with large index discontinuity.
Kinetics of the Reaction of CO<sub>2</sub> with Aqueous Formulated Solution Containing Monoethanolamine, <i>N</i>-Methyl-2-pyrrolidone, and Diethylene Glycol (2005)

The kinetics of the reaction of CO2 with aqueous formulated solutions containing 50 wt % N-methyl-2-pyrrolidone (NMP) and 10 wt % diethylene glycol (DEG) (relative to water) and various amounts of monoethanolamine (MEA) were studied in a stirred cell reactor with an undisturbed gas−liquid interface at 303 K, using the fall in pressure technique. The MEA concentration in the formulated solution was varied in the range 1.5−2.5 kmol m-3. The densities and viscosities of these amine solutions were measured. The physical properties such as solubility and diffusivity of CO2 in these amine solutions were estimated using N2O analogy. The overall reaction could be regarded as a reaction between CO2 and MEA in parallel with the reaction of CO2 with NMP.