gebhart/patrepeval huggingface dataset:
SU‐FF‐I‐124: Anthropomorphic Uterus Phantoms for Testing Elastography Systems (2007)

Purpose: To develop uterine phantoms for mimicking in vivo ultrasound strain imaging in saline infused sonohysterography (SIS) and employ them to compare strain imaging (elastography) systems. Method and Materials: Dimensions and shapes of the two phantoms simulate the uterus of a pre‐menopausal woman with no previous pregnancy. Phantoms were constructed using tissue‐mimicking (TM) materials consisting of dispersions of safflower oil in gelatin. 10%, 70% and 80%, oil dispersions represent fibroids, endometrial polyps, and fat, respectively. Myometrium and cervical tissues were represented by 40% in one phantom and 50% in the other. In the first uterine phantom, 3‐mm diameter TM fibroids were randomly distributed in TM myometrium. The second uterine phantom has a 10‐mm fibroid on the serosal surface and 5‐mm and 8‐mm spherical fibroids and 5‐mm spherical and 8‐mm × 5‐mm peg shaped endometrial polyps protruding into the endometrial cavity. Samples for determining physical properties were made at the time of phantom production. RF data was acquired during a volume expansion of the endometrial cavity using the Siemens Antares VFX 13‐5 and 9‐4 transducers at 11 and 9 MHz, respectively, on the Aloka SSD 2000 at 7.5 MHz, and on a third system at 4 MHz. Strain images were generated using a 2‐D block matching or a 2‐D multilevel strain estimation technique. Results: Strain images from the first phantom show stiffer 3‐mm inclusions in the myometrium. In the second phantom, strain images show the part of the endometrial polyps projecting into the endometrial cavity appeared stiffer and the part in the myometrium softer compared to the myometrium. Strain images from the Aloka and the third system were of lower quality than the Siemens Antares. Conclusion: Durable uterine SIS phantoms with well‐defined properties can be produced to allow realistic quantitative testing of SIS strain imaging using ultrasound.
High-frequency modulation and suppression of chirp in semiconductor lasers (1993)

We propose a new method for modulating laser radiation by controlling simultaneously the pumping current and the optical gain in the active region. The latter can be independently varied by modulating the effective carrier temperature. The method allows to eliminate the relaxation oscillations and enhance the modulation frequency to 50 GHz. It also allows to suppress the wavelength chirping in optical communication systems operating at pulse repetition rates of 10 Gb/s.
Sequential Immunization with Vesicles Prepared from Heterologous<i>Neisseria meningitidis</i>Strains Elicits Broadly Protective Serum Antibodies to Group B Strains (2002)

The capsular polysaccharide of Neisseria meningitidis group B is an autoantigen, whereas noncapsular antigens are highly variable. These factors present formidable challenges for development of a broadly protective and safe group B vaccine. Mice and guinea pigs were sequentially immunized with three doses of micovesicles or outer membrane vesicles prepared from three meningococcal strains that were each antigenically heterologous with respect to the two major porin proteins, PorA and PorB, and the group capsular polysaccharide. The resulting antisera conferred passive protection against meningococcal group B bacteremia in infant rats and elicited complement-mediated bactericidal activity against genetically diverse group B strains that were either homologous or heterologous with respect to PorA of the strains used to prepare the vaccine. By using knockout strains, a portion of the bactericidal antibody was directed against the highly conserved protein, neisserial surface protein A (NspA). Further, an anti-NspA monoclonal antibody elicited by the sequential immunization was highly bactericidal against strains that were previously shown to be resistant to bacteriolysis by anti-NspA antibodies produced by immunization with recombinant NspA. Sequential immunization with heterologous vesicle preparations offers a novel approach to eliciting broadly protective immunity against N. meningitidis strains. An NspA-based vaccine prepared from protein expressed by Neisseria also may be more effective than the corresponding recombinant protein made in Escherichia coli.
Electric field coupling to short dipole receivers in cavity mode enabled wireless power transfer (2015)

This work provides a method of wireless power transfer that uses the resonant modes of a metallic cavity to deliver power to a small dipole nearly anywhere within the structure. We derive an expression for the coupling coefficient between the E→-fields of the cavity mode and the dipole, and then validate the analytic model via finite element simulations. Lastly, we use the results for the coupling coefficient to predict the wireless power transfer efficiency as the dipole is moved throughout the chamber.
Characterizing viscoelastic properties of asphalt mixtures utilizing loaded wheel tester (LWT) (2012)

The performance of asphalt mixture is governed by its viscoelastic properties, especially those in tension mode. However, due to the difficulties in performing tests in direct tension mode, the test methods commonly used are in either compression or indirect tension (diametrical compression) mode. Previous studies show that loading mode has a significant effect on the viscoelastic properties of asphalt mixtures, especially at high temperatures. It is of great importance to develop a testing method to effectively and efficiently characterize the tensile properties of asphalt mixtures. In this study, a flexural tension test was proposed to utilize a loaded wheel tester (LWT) to characterize the viscoelastic properties of asphalt mixtures. In this test, beam specimens were subjected to constant or cyclic loads provided by moving wheels of a LWT. With transducers mounted on the beam, flexural bend deformations are measured. In addition to the LWT test, uniaxial tests in tension mode, tension-compression mode, and compression mode as well as indirect tension creep test were conducted on the same asphalt mixtures for comparison and validation. The results showed that the LWT test was able to characterize the viscoelastic properties of asphalt mixtures made with different aggregates and asphalt binders. The results from the LWT tests were found to be in general accordance with those from other tests. Compared to uniaxial and indirect tension tests, the LWT test could better represent the stress state in pavements and thus was more suitable for characterizing the viscoelastic properties of asphalt mixtures.
An implementation of CMOS design for testability techniques for non stuck-at faults (2002)

An experimental analysis of design for testability (DFT) techniques used to detect the presence of faulty resistive paths throughout CMOS ICs is presented. Current monitoring, delay fault testing and new design for testability (DFT) techniques are compared by means of a chip designed ad hoc. It allows simulation via hardware of the presence of resistive bridgings within standard functional blocks. The results suggest that specific DFT techniques offer considerable advantages over more conventional approaches.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Sensor Agnostic Photoplethysmogram Signal Quality Assessment using Morphological Analysis (2017)

In this article, we propose a method to assess the clinical usability of fingertip Photoplethysmogram (PPG) waveform, collected from medical grade oximeter (train data) and smartphone (test data). We introduce a set of novel Signal Quality Indices (SQIs) to represent the noise characteristics of the PPG waveform. The SQIs are presented to a random forest classifier to discriminate between clean and noisy signals. The proposed method was evaluated on datasets annotated by four experts, resulting into a sensitivity and specificity of (92 ± 4.7 %, 95 ± 3 %) and (82.6 ± 4.6 %, 95.4 ± 3.1 %) on train and test data respectively. Further we applied the proposed method on PPG waveform of clinically proven control and disease population of Coronary Artery Disease (CAD), which resulted into (77 %, 77 %) of sensitivity and specificity respectively.
Design and implementation of a parallel priority queue on many-core architectures (2012)

An efficient parallel priority queue is at the core of the effort in parallelizing important non-numeric irregular computations such as discrete event simulation scheduling and branch-and-bound algorithms. GPGPUs can provide powerful computing platform for such non-numeric computations if an efficient parallel priority queue implementation is available. In this paper, aiming at fine-grained applications, we develop an efficient parallel heap system employing CUDA. To our knowledge, this is the first parallel priority queue implementation on many-core architectures, thus represents a breakthrough. By allowing wide heap nodes to enable thousands of simultaneous deletions of highest priority items and insertions of new items, and taking full advantage of CUDA's data parallel SIMT architecture, we demonstrate up to 30-fold absolute speedup for relatively fine-grained compute loads compared to optimized sequential priority queue implementation on fast multicores. Compared to this, our optimized multicore parallelization of parallel heap yields only 2-3 fold speedup for such fine-grained loads. This parallelization of a tree-based data structure on GPGPUs provides a roadmap for future parallelizations of other such data structures.
A five‐microRNA model (<i>pCaP</i>) for predicting prostate cancer aggressiveness using cell‐free urine (2019)

Improved biomarkers for prostate cancer (PC) risk stratification are urgently needed. Here, we aimed to develop a novel multimarker model for prediction of biochemical recurrence (BCR) after curatively intended radical prostatectomy (RP), based on minimally invasive sampling of blood and urine. We initially measured the levels of 45 selected miRNAs by RT-qPCR in exosome enriched cell-free urine samples collected prior to RP from 215 PC patients (Cohort 1, training). We trained a novel logistic regression model (pCaP), comprising five urine miRNAs (miR-151a-5p, miR-204-5p, miR-222-3p, miR-23b-3p and miR-331-3p) and serum prostate-specific antigen (PSA), which significantly predicted time to BCR in Cohort 1 (univariate Cox regression analysis: HR = 3.12, p < 0.001). Next, using the same exact numeric cutoff for dichotomization as trained in Cohort 1, we tested and successfully validated the prognostic potential of pCaP in two additional cohorts, including 199 (Cohort 2, HR = 2.24, p = 0.002) and 205 (Cohort 3, HR = 2.15, p = 0.004) RP patients, respectively. pCaP remained a significant predictor of BCR, also after adjustment for pathological T-stage, surgical margin status and Gleason grade group (p < 0.05 in multivariate Cox regression analysis: HR = 2.72, 1.94 and 1.83 for Cohorts 1, 2 and 3, respectively). Additionally, pCaP scores correlated positively with the established clinical risk stratification nomogram CAPRA in all three PC cohorts (Pearson's rho: 0.45, 0.39 and 0.44). Together, our results suggest that the minimally invasive pCaP model could potentially be used in the future to improve PC risk stratification and to guide more personalized treatment decisions. Further clinical validation studies are warranted.
Frequency stabilized direct GMSK modulator (2002)

A phase locked loop based architecture is proposed for generation and frequency stabilization of direct Gaussian minimum shift keying (GMSK) at microwave and millimeterwave frequencies. A continuous phase frequency shift keyed (CPFSK) signal with a modulation index of 0.5 is produced at the desired output frequency using a full 360 degree linear continuous phase modulator that is controlled by the integrated baseband information signal. This modulated signal is used as the reference signal for a phase locked high power voltage controlled oscillator. The phase locked loop facilitates reference signal frequency tracking and provides Gaussian spectral shaping to the modulated output signal. Phase locked loop imperfections and their effect on the modulated output signal are considered and simulation results are presented.
Ultrastable Superbase-Derived Protic Ionic Liquids (2009)

Protic ionic liquids are synthesized via proton transfer from acids to organic bases. One of the key issues associated with conventional protic ionic liquids is the thermal instability resulting from temperature-induced decomposition via reverse proton transfer. This shortcoming significantly hampers the use of these protic ionic liquids in separations, electrochemical capacitors, fuel cells, and so forth. Herein we show that it is possible to prepare protic ionic liquids with thermal stabilities approaching those of common aprotic ionic liquids. Our new class of protic ionic liquids, derived via integrated neutralization and metathesis of superbasic phosphazenes or guanidines, exhibits exceptionally low vapor pressures at 150 degrees C while being stable to strong alkali agents such as aqueous KOH, suggesting potential in energy-related applications, including electrochemical capacitors and PEM-type fuel cells.
Protective Effects of Lactobacillus plantarum CCFM8610 against Chronic Cadmium Toxicity in Mice Indicate Routes of Protection besides Intestinal Sequestration (2014)

Our previous study confirmed the ability of Lactobacillus plantarum CCFM8610 to protect against acute cadmium (Cd) toxicity in mice. This study was designed to evaluate the protective effects of CCFM8610 against chronic Cd toxicity in mice and to gain insights into the protection mode of this strain. Experimental mice were divided into two groups and exposed to Cd for 8 weeks via drinking water or intraperitoneal injection. Both groups were further divided into four subgroups, control, Cd only, CCFM8610 only, and Cd plus CCFM8610. Levels of Cd were measured in the feces, liver, and kidneys, and alterations of several biomarkers of Cd toxicity were noted. The results showed that when Cd was introduced orally, cotreatment with Cd and CCFM8610 effectively decreased intestinal Cd absorption, reduced Cd accumulation in tissue, alleviated tissue oxidative stress, reversed hepatic and renal damage, and ameliorated the corresponding histopathological changes. When Cd was introduced intraperitoneally, administration of CCFM8610 did not have an impact on tissue Cd accumulation or reverse the activities of antioxidant enzymes. However, CCFM8610 still offered protection against oxidative stress and reversed the alterations of Cd toxicity biomarkers and tissue histopathology. These results suggest that CCFM8610 is effective against chronic cadmium toxicity in mice. Besides intestinal Cd sequestration, CCFM8610 treatment offers direct protection against Cd-induced oxidative stress. We also provide evidence that the latter is unlikely to be mediated via protection against Cd-induced alteration of antioxidant enzyme activities.
WAN optimized replication of backup datasets using stream-informed delta compression (2012)

Replicating data off-site is critical for disaster recovery reasons, but the current approach of transferring tapes is cumbersome and error-prone. Replicating across a wide area network (WAN) is a promising alternative, but fast network connections are expensive or impractical in many remote locations, so improved compression is needed to make WAN replication truly practical. We present a new technique for replicating backup datasets across a WAN that not only eliminates duplicate regions of files (deduplication) but also compresses similar regions of files with delta compression, which is available as a feature of EMC Data Domain systems.Our main contribution is an architecture that adds stream-informed delta compression to already existing deduplication systems and eliminates the need for new, persistent indexes. Unlike techniques based on knowing a file's version or that use a memory cache, our approach achieves delta compression across all data replicated to a server at any time in the past. From a detailed analysis of datasets and hundreds of customers using our product, we achieve an additional 2X compression from delta compression beyond deduplication and local compression, which enables customers to replicate data that would otherwise fail to complete within their backup window.
Hyperspectral Multiphoton Microscopy: Demonstration of 48-channel Imaging In Vivo (2015)

We constructed a hyperspectral multiphoton microscope that records 48 channels of excitation/emission spectral data per pixel, while remaining insensitive to optical scattering. We demonstrate imaging of multiple spectrally overlapping fluorophores in mouse cortex, in vivo.
A paradigm linking herpesvirus immediate-early gene expression apoptosis and myalgic encephalomyelitis chronic fatigue syndrome (2011)

Abstract: There is no accepted science to relate herpesviruses (Epstein–Barr virus [EBV], human cytomegalovirus [HCMV], and human herpesvirus 6 [HHV6]) as causes of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). ME/CFS patients have elevated serum immunoglobulin (Ig)G serum antibody titers to EBV, HCMV, and HHV6, but there is no herpesvirus DNA-emia, herpesvirus antigenemia, or uniformly elevated IgM serum antibody titers to the complete virions. We propose that herpesvirus EBV, HCMV, and HHV6 immediate-early gene expression in ME/CFS patients leads to host cell dysregulation and host cell apoptosis without lytic herpesvirus replication. Specific antiviral nucleosides, which alleviate ME/CFS, namely valacyclovir for EBV ME/CFS and valganciclovir for HCMV/HHV6 ME/CFS, inhibit herpesvirus DNA polymerases and/or thymidine kinase functions, thus inhibiting lytic virus replication. New host cell recruitment thus ceases. In the absence of new herpesvirus, nonpermissive herpesvirus replication stops, and ME/CFS recovery ensues. Keywords: ME/CFS, Epstein–Barr virus (EBV), human cytomegalovirus (HCMV), HHV6, abortive replication
Feasibility study of a new game-based bimanual integrative therapy (2013)

Therapeutic games motivate patients and intrinsically generate a large number of movement repetitions that is key to inducing brain plasticity and facilitating recovery. While virtual rehabilitation has gained clinical acceptance, bimanual therapy is less developed at this time. The novel RABBIT system combines physical and cognitive training via integrative game-play sessions. Using the Razer Hydra game interface, patients play a series of custom games designed to improve attention, decision making (executive function), short-term and long-term memory. These games progress in difficulty over 6 weeks of therapy. The system and its first feasibility study on patients who were chronic post-stroke are presented here.
Reconfigurable antenna solution for MIMO-OFDM systems (2006)

A reconfigurable microstrip dipole antenna solution for multiple-input multiple-output (MIMO) communication systems making use of orthogonal frequency division multiplexing (OFDM) is presented. When applied to closely spaced antenna arrays, this method can increase link capacity. The benefits of this novel antenna solution are demonstrated by channel capacity measurements taken in an indoor environment with a 2×2 MIMO system.
Organic light-emitting devices for solid state lighting (2007)

We present recent progress in developing efficient organic light-emitting devices and novel low-cost device fabrication for solid-state lighting applications.
Recent results in imaging lidar (1997)

Imaging lidar, in which light detection and ranging is implemented with sufficient spatial resolution to resolve the size and shape of an object, has demonstrated impressive performance for detecting and classifying underwater targets. During 1996 the U.S. Navy deployed its first imaging lidar system with Naval Air Reserve Squadron HSL-94. This paper reviews the Magic Lantern<sup>R</sup> system and discusses new technology and trends for future systems.
Inactivated or Live-Attenuated Bivalent Vaccines That Confer Protection against Rabies and Ebola Viruses (2011)

The search for a safe and efficacious vaccine for Ebola virus continues, as no current vaccine candidate is nearing licensure. We have developed (i) replication-competent, (ii) replication-deficient, and (iii) chemically inactivated rabies virus (RABV) vaccines expressing Zaire Ebola virus (ZEBOV) glycoprotein (GP) by a reverse genetics system based on the SAD B19 RABV wildlife vaccine. ZEBOV GP is efficiently expressed by these vaccine candidates and is incorporated into virions. The vaccine candidates were avirulent after inoculation of adult mice, and viruses with a deletion in the RABV glycoprotein had greatly reduced neurovirulence after intracerebral inoculation in suckling mice. Immunization with live or inactivated RABV vaccines expressing ZEBOV GP induced humoral immunity against each virus and conferred protection from both lethal RABV and EBOV challenge in mice. The bivalent RABV/ZEBOV vaccines described here have several distinct advantages that may speed the development of inactivated vaccines for use in humans and potentially live or inactivated vaccines for use in nonhuman primates at risk of EBOV infection in endemic areas.
Overcoming Taxane Resistance: Preclinical and Phase 1 Studies of Relacorilant, a Selective Glucocorticoid Receptor Modulator, with Nab-Paclitaxel in Solid Tumors (2022)

The observed preclinical, clinical, and GR-specific pharmacodynamic responses demonstrate that selective GR modulation with relacorilant combined with nab-paclitaxel may promote chemotherapy response and is tolerable. Further evaluation of this combination in tumor types responsive to taxanes is ongoing.
Hydrogenolytic Denitration of Polynitro Compounds. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Fast leaf-fitting with generalized underdose/overdose constraints for real-time MLC tracking (2015)

This work improves upon the quality of the Sawant et al. approach, but does so without sacrificing run-time performance. In addition, using this framework allows for complex leaf-fitting strategies that can be used to account for PTV/OAR trade-off during real-time MLC tracking.