gebhart/patrepeval huggingface dataset:
Is Endometriosis Associated with Systemic Subclinical Inflammation? (2006)

Endometriosis is a pelvic inflammatory process with altered function of immune-related cells and increased number of activated macrophages in the peritoneal environment that secrete various local products, such as growth factors and cytokines. The elevation of cytokines and other factors in the peritoneal fluid is accompanied by the elevation of similar factors, such as CRP, SAA, TNF-alpha, MCP-1, IL-6, IL-8 and CCR1, in the peripheral blood of patients with endometriosis. CD44+ and CD14+ monocytes are significantly increased, while CD3+ T lymphocytes and CD20+ B lymphocytes show modest, but significant decrease in peripheral blood of women with endometriosis. This indicates that endometriosis could be viewed as a local disease with systemic subclinical manifestations. This review provides an overview of data on the changes of various factors in peripheral blood and their potential use as diagnostic tools in patients with endometriosis.
Energy barriers for dipole moment flipping in PVDF-related ferroelectric polymers (2016)

Energy barriers for flipping the transverse dipole moments in poly(vinylidene fluoride) (PVDF) and related copolymers and terpolymers are predicted using the nudged elastic band method. The dipole moments flip individually along the chain, with an order and energy barrier magnitudes (0.1-1.2 eV) that depend on the chain composition and environment. Trifluoroethylene (TrFE) and chlorofluoroethylene (CFE) monomers have larger energy barriers than VDF monomers, while a chain in an amorphous environment has a similar transition pathway as that of an isolated molecule. In a crystalline environment, TrFE and CFE monomers expand the lattice and lower the energy barriers for flipping VDF monomers. This finding is consistent with experimental observations of a large electrocaloric effect in P(VDF-TrFE-CFE) terpolymers.
A Framework for Assessing Technology Risks in Transaction-Based Extended Enterprises: U.S. Capital Market Case (2016)

Ensuring operational reliability of the technology-based systems processing transactions for industries such as the U.S. capital market is vital to the global economy. Within this context, monitoring operational IT risk levels (a component of enterprise risk management) across the various supply chains or “extended enterprises” (EEs) making up these highly automated sectors becomes particularly important. This paper proposes an approach for segmentation of complex industries such as the U.S. capital markets into EEs and assessing their IT operational risk level. The concept of EE technology risk index is introduced and modified with the use of fault tree analysis to help oversight groups monitoring technology risks for this type of industry. The proposed methodology is illustrated with one of the EEs within the U.S. capital market. Observations on the approach and potential future research is discussed.
Synthetic Pathways to Hydrogen-Rich Polysilylated Arenes from Trialkoxysilanes and Other Precursors (2002)

The use of tri(alkoxy)silanes (RO)3SiH, which have recently become commercially available in greater than research scale quantities (R = Me, Et), has been probed for the preparation of hydrogen-rich arylsilanes ArSiH3. It was found that the silylation of aryl-lithium or (in situ) aryl-Grignard reagents is followed by RO/H ligand redistribution and can lead to fully hydrogenated products in a one-pot reaction without employment of any additional metal hydride. After hydrolytic workup, the overall yields are between 20 and 30%. Silane gas and tetra(alkoxy)silanes are the main byproducts. At an early stage of the reactions, the whole set of mixed-ligand silanes (RO)3-nHnSiAr can be detected by GLC/MS techniques. Induced by the organometallic base, the reaction also includes aryl scrambling to give silanes ArnSiH4-n, ArnSi(OR)4-n, and ArnSi(H/OR)4-n. A reaction scheme is proposed that accounts for the product distribution. Examples are given for Ar = phenyl, 4-biphenylyl, 4,4'-biphenyldiyl, 1-naphthyl, and 2-anisyl. The reaction gives only very poor yields of di(silyl)arenes. Silanes of this type were therefore prepared from (RO)3SiH compounds and the corresponding di(halo)arenes by the in situ Grignard procedure followed by LiAlH4 reduction. Representative cases are 1,2- and 1,4-di(silyl)benzene and 1,4-di(silyl)-2,5-dimethylbenzene. The primary reaction products 1,4-(EtO)3SiC6H4Si(OEt)3 and 1,4-[(EtO)3Si]2-2,5-(CH3)2C6H2 have been isolated, and the crystal structure of the latter was determined.
Spartacus (2013)

Recent developments in ubiquitous computing enable applications that leverage personal mobile devices, such as smartphones, as a means to interact with other devices in their close proximity. In this paper, we propose Spartacus, a mobile system that enables spatially-aware neighboring device interactions with zero prior configuration. Using built-in microphones and speakers on commodity mobile devices, Spartacus uses a novel acoustic technique based on the Doppler effect to enable users to accurately initiate an interaction with a neighboring device through a pointing gesture. To enable truly spontaneous interactions on energy-constrained mobile devices, Spartacus uses a continuous audio-based lower-power listening mechanism to trigger the gesture detection service. This eliminates the need for any manual action by the user. Experimental results show that Spartacus achieves an average 90% device selection accuracy within 3m for most interaction scenarios. Our energy consumption evaluations show that, Spartacus achieves about 4X lower energy consumption than WiFi Direct and 5.5X lower than the latest Bluetooth 4.0 protocols.
Evaluation of Pozzolanic Activity of Rice Husk Ash (1992)

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Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model (2014)

Our results suggest that elevation of brain magnesium exerts substantial synaptoprotective effects in a mouse model of Alzheimer's disease, and hence it might have therapeutic potential for treating Alzheimer's disease.
α-Substituted Malonester Amides:  Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity (1998)

We prepared a series of alpha-substituted malonester amides that were evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase activity in vitro and to lower plasma total cholesterol levels in a variety of cholesterol-fed animal models. Compounds of this series were also useful in examining the relationship between adrenal toxicity and ACAT inhibition. One compound from this series, 9f, was a potent inhibitor of ACAT in both the microsomal and cellular assays. It was also bioavailable as determined by both a bioassay and a HPLC-UV assay. This compound was evaluated in both guinea pig and dog models of adrenal toxicity and compared to tetrazole amide 15. In the most sensitive species, the dog, both of these compounds achieved good plasma levels; however, compound 9f caused adrenal necrosis, whereas compound 15 had no effect on the adrenal gland. This adds to the growing body of evidence that the adrenal toxicity observed with ACAT inhibitors may not be mechanism related.
FANTOM PROJECT : Electronic Speckle Pattern Interferometry at Thermal Infrared Wavelengths, A New Technique for Combining Temperature and Displacement Measurements (2010)

We present a novel technique which suitably combines thermographic and displacement full-field measurement by performing electronic speckle pattern interferometry at thermal infrared wavelengths, associating CO2 lasers with microbolometer thermal imagers. Application in observing thermomechanical behaviour of composite structures is presented.
Ultrasensitive mass sensor fully integrated with complementary metal-oxide-semiconductor circuitry (2005)

Nanomechanical resonators have been monolithically integrated on preprocessed complementary metal-oxide-semiconductor (CMOS) chips. Fabricated resonator systems have been designed to have resonance frequencies up to 1.5 MHz. The systems have been characterized in ambient air and vacuum conditions and display ultrasensitive mass detection in air. A mass sensitivity of 4ag∕Hz has been determined in air by placing a single glycerine drop, having a measured weight of 57 fg, at the apex of a cantilever and subsequently measuring a frequency shift of 14.8 kHz. CMOS integration enables electrostatic excitation, capacitive detection, and amplification of the resonance signal directly on the chip.
A micromanipulation system with dynamic force-feedback for automatic batch microinjection (2007)

10.1088/0960-1317/17/2/018
Coronary Calcium Measurements by Double Helical Computed Tomography (1997)

Using the average instead of conventional peak density score provides better reproducible measurements of calcium by double helical CT.
PREFACE (2013)

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High efficiency reflective waveplates in the midwave infrared (2014)

We demonstrate a high efficiency reflective waveplate which exhibits incidence angle dependent phase shift tuning capabilities in the midwave infrared. Using Finite Difference Time Domain (FDTD) modeling, the phase shift and reflection efficiency are simulated for a variety of geometrical parameters, the results of which are then employed to optimize design. Devices were fabricated and both the polarization and efficiency characteristics were measured and compared to FDTD simulations showing excellent agreement. Further, the potential for scalability to other wavelength ranges and the capability to generate an arbitrary phase shift are explored to demonstrate the versatility of our design.
Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction (2020)

ClinicalTrials.gov Identifier: NCT03547583.
Review of Topical Treatment of Upper Tract Urothelial Carcinoma (2008)

A select group of patients with upper tract urothelial carcinoma may be appropriate candidates for minimally invasive management. Organ-preserving endoscopic procedures may be appropriate for patients with an inability to tolerate major surgery, solitary kidney, bilateral disease, poor renal function, small tumor burden, low-grade disease, or carcinoma in situ. We review the published literature on the use of topical treatment for upper tract urothelial carcinoma and provide our approach to treatment in the office setting.
Dual energy window scatter corrections for positron emission tomography (2002)

A simulation of PET (positron emission tomography) was used to investigate dual energy window scatter correction for PET devices. Two types of off-peak energy windows were examined. Method one only accepts coincidences where the detected energies of both photons are in the off-peak energy window; method two accepts coincidences where the detected energy of one photon is in the off-peak window and the detected energy of the other photon is in either the off-peak or on-peak window. Profiles of the coincidence accepted by these methods were compared to profiles of the scatter coincidences detected in the on-peak window. Neither method produces a good approximation to the shape of the scatter coincidence profile. Method one has little to recommend it over a constant background subtraction. Method two yields profiles that looked even less useful, dipping down where the scatter coincidence profile rises.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Highly aliased ground-roll suppression using a 3D multiwindow Karhunen-Loève filter: Application to a legacy Mississippi Lime survey (2016)

ABSTRACT Although modern recording capacity facilitates dense seismic acquisition, many, if not most, legacy 3D land surveys are spatially aliased with respect to ground roll. Irregular topography and weathering zones give rise to ground roll that has piecewise rather than continuous linear moveout (LMO). Dispersion often results in shingled events whose phase velocity cuts across the ground-roll noise cone. We have developed a workflow for the suppression of highly aliased broadband ground roll in which modern f-kx-ky filters failed. Our workflow began with low-pass filtering and windowing the data, 3D patch by 3D patch. We then applied LMO corrections using an average phase velocity of the ground roll and improved these moveout corrections through the use of local three-shot by three-receiver 3D velocity scans about each sample to account for lateral changes in velocity, thickness, and weathering zone topography. Using a Kuwahara algorithm, we chose the most coherent window within which we applied a structure-oriented Karhunen-Loève filter to model the coherent noise. Finally, we removed the LMO correction and subtracted the modeled ground roll from the original data. We applied our workflow to a legacy data volume consisting of four merged 3D surveys acquired in the 1990s. Application of modern seismic attributes showed improved mapping of faults and flexures. We also validated our workflow using a synthetic gather having the same geometry as our field data.
Identification of multiple, novel, protein kinase C‐related gene products (1994)

A PCR approach has been employed to screen two cDNA libraries for PKC(-related) sequences. In each case multiple cDNAs were identified, including known PKC isotypes, a previously unknown PKC-eta related sequence and three members of what appears to be a protein kinase C related kinase (PRK 1-3) family. The origin and relationships of these predicted proteins is discussed.
A Photoconductive Thienothiophene‐Based Covalent Organic Framework Showing Charge Transfer Towards Included Fullerene (2013)

Filling a honeycomb: The thienothiophene-based covalent organic framework (COF) can be loaded with a complementary semiconductor, such as a fullerene derivative, and electronic interactions are observed (see figure). The novel periodic interpenetrated donor–acceptor system shows the spectroscopic signatures of efficient charge transfer on the nanoscale. Photovoltaic activity was demonstrated upon integrating the COF:fullerene film into a device. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Large increase in brazzein expression achieved by changing the plasmid /strain combination of the NICE system in<i>Lactococcus lactis</i> (2009)

The choice of the plasmid/strain combination of the NICE system was shown to be of extreme importance in brazzein expression.
Practical protection and control strategies during large power-system disturbances (2002)

Disturbances in power systems can take the form of large and sudden changes, such as loss of a large generating unit or fault on a critical part of the system. In case of an emergency, control and/or protection actions are required to return the system back to a normal, secure state as soon as possible. Historically, only centralized control was used because only at this level were computers and communications economically justified. With the increased availability of sophisticated computer, communication and measurement technologies, more "intelligent" equipment can be used at the local level to improve the overall emergency response. In this paper, present design practices for emergency protection equipment are analyzed. Attributes of typical underfrequency load-shedding schemes are described. Implementation of the rate-of-change-of-frequency function is evaluated and adaptive features suggested. Intelligent emergency control strategies to prevent system islanding, frequency drop, and voltage instability are proposed.
La paradoja de la innovación (2004)

Los datos reunidos por un estudio de Deloitte entre 650 fabricantes globales demuestran que esto es cierto en todos los sectores, desde la fabricacion de productos de consumo hasta la farmaceutica y las altas tecnologias. Estos datos tambien sugieren que para sobrevivir y tener exito en un mercado global cada vez mas complejo es crucial superar la paradoja de la innovacion
Unraveling the Molecular Weight Dependence of Interfacial Interactions in Poly(2-vinylpyridine)/Silica Nanocomposites (2017)

The structure and polymer-nanoparticle interactions among physically adsorbed poly(2-vinylpyridine) chains on the surface of silica nanoparticles (NPs) were systematically studied as a function of molecular weight (MW) by sum frequency generation (SFG) and X-ray photoelectron (XPS) spectroscopies. Analysis of XPS data identified hydrogen bonds between the polymer and NPs, while SFG evaluated the change in the number of free OH sites on the NP's surface. Our data revealed that the hydrogen bonds and amount of the free -OH sites have a significant dependence on the polymer's MW. These results provide clear experimental evidence that the interaction of physically adsorbed chains with nanoparticles is strongly MW dependent and aids in unraveling the microscopic mechanism responsible for the strong MW dependence of dynamics of the interfacial layer in polymer nanocomposites.
DARE: Dynamic Adaptive Mobile Augmented Reality with Edge Computing (2018)

Mobile augmented reality (MAR) is a killer application of mobile edge computing because of its high computation demand and stringent latency requirement. Since edge networks and computing resources are highly dynamic, handling such dynamics is essential for providing high-quality MAR services. In this paper, we design a new network protocol named DARE (dynamic adaptive AR over the edge) that enables mobile users to dynamically change their AR configurations according to wireless channel conditions and computation workloads in edge servers. The dynamic configuration adaptations reduce the service latency of MAR users and maximize the quality of augmentation (QoA) under varying network conditions and computation workloads. Considering the video frame size and computation model, i.e., object detection algorithms, as two key parameters in adapting the AR configuration, we develop analytical models to characterize the impact of these parameters on QoA and the service latency. Then, we design optimization mechanisms on both the edge server and AR devices to guide the AR configuration adaptation and server computation resource allocation. The performance of the DARE protocol is validated through a small-scale testbed implementation.
A context for pen-Based mathematical computing (2005)

We report on an investigation to determine an architectural framework for pen-based mathematical computing. From the outset, we require that the framework be integrated with suitable elements for pen computing, document processing and computer algebra. We demonstrate that this architecture is able to provide these interfaces and allows a high degree of platform independence for the development of pen-based mathematical software.
Structurally Enabled Discovery of Adenosine A<sub>2A</sub> Receptor Antagonists (2016)

Over the past decade there has been a revolution in the field of G protein-coupled receptor (GPCR) structural biology. Many years of innovative research from different areas have come together to fuel this significant change in the fortunes of this field, which for many years was characterized by the paucity of high-resolution structures. The determination to succeed has been in part due to the recognized importance of these proteins as drug targets, and although the pharmaceutical industry has been focusing on these receptors, it can be justifiably argued and demonstrated that many of the approved and commercially successful GPCR drugs can be significantly improved to increase efficacy and/or reduce undesired side effects. In addition, many validated targets in this class remain to be drugged. It is widely recognized that application of structure-based drug design approaches can help medicinal chemists a long way toward discovering better drugs. The achievement of structural biologists in providing high-resolution insight is beginning to transform drug discovery efforts, and there are a number of GPCR drugs that have been discovered by use of structural information that are in clinical development. This review aims to highlight the key developments that have brought success to GPCR structure resolution efforts and exemplify the practical application of structural information for the discovery of adenosine A<sub>2A</sub> receptor antagonists that have potential to treat multiple conditions.
Force Reflection for WIMPs: A Button Acquisition Experiment (1997)

Abstract The purpose of this study was to evaluate whether the common computer-interface task of button acquisition is performed more rapidly when buttons are surrounded by force attraction basins. Button acquisition time measures were obtained from five participants for each of five different pointer device configurations. A normal mouse served as control, and the remaining four configurations used a normal mouse mechanically linked to the end-effector of a PHANToM force-reflection mechanism (SensAble Devices, Cambridge, MA). Two configurations applied forces on the mouse in the direction of a (graphical) button whenever the cursor was in the vicinity of the button. Anchoring the PHANToM to the mouse also allowed comparing relative and absolute pointer positioning. Over all participants, mean button acquisition time improvements of at least 10% were obtained when using force reflection. Individual means were in every case better when force-reflection was used. Across participants, there was no difference between absolute and relative positioning, whether or not force-reflection was enabled.