gebhart/patrepeval huggingface dataset:
<title>CSVD: approximate similarity searches in high-dimensional spaces using clustering and singular value decomposition</title> (1998)

Many data-intensive applications, such as content-based retrieval of images or video from multimedia databases and similarity retrieval of patterns in data mining, require the ability of efficiently performing similarity queries. Unfortunately, the performance of nearest neighbor (NN) algorithms, the basis for similarity search, quickly deteriorates with the number of dimensions. In this paper we propose a method called Clustering with Singular Value Decomposition (CSVD), combining clustering and singular value decomposition (SVD) to reduce the number of index dimensions. With CSVD, points are grouped into clusters that are more amenable to dimensionally reduction than the original dataset. Experiments with texture vectors extracted from satellite images show that CSVD achieves significantly higher dimensionality reduction than SVD along for the same fraction of total variance preserved. Conversely, for the same compression ratio CSVD results in an increase in preserved total variance with respect to SVD (e.g., at 70% increase for a 20:1 compression ratio). Then, approximate NN queries are more efficiently processed, as quantified through experimental results.
Image Enhancement for Backlight-Scaled TFT-LCD Displays (2009)

One common way to extend the battery life of a portable device is to reduce the LCD backlight intensity. In contrast to previous approaches that minimize the power consumption by adjusting the backlight intensity frame by frame to reach a specified image quality, the proposed method optimizes the image quality for a given backlight intensity. Image is enhanced by performing brightness compensation and local contrast enhancement. For brightness compensation, global image statistics and backlight level are considered to maintain the overall brightness of the image. For contrast enhancement, the local contrast property of human visual system (HVS) is exploited to enhance the local image details. In addition, a brightness prediction scheme is proposed to speed up the algorithm for display of video sequences. Experimental results are presented to show the performance of the algorithm.
Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease (2011)

The results showed that the reactivity of the moAb G12 is proportional to the potential immunotoxicity of the cereal cultivar. These differences may explain the different clinical responses observed in patients suffering from CD and open up a means to identify immunologically safe oat cultivars, which could be used to enrich a gluten-free diet.
Age‐dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: Lack of influence of carcinogen or testosterone treatment (2003)

Sequential changes in the phenotype of prostatic lesions and the impact of additional carcinogen treatment or castration on development and progression of prostate cancers were examined in probasin/simian virus 40 (SV40) T antigen transgenic (TG) rats. Non-invasive prostate adenocarcinomas were evident in all lobes at 15 weeks of age. Invasive tumors were limited to the anterior lobe at this time point and were found in all lobes in an age-dependent manner thereafter. No metastasis was apparent at any age. Additional carcinogen treatment or castration did not enhance progression or generate selective growth of hormone-independent prostate cancer cells. These results suggest that our TG rats are suitable for clarification of mechanisms in early stages of prostate carcinogenesis, that is, from prostatic intraepithelial neoplasia (PIN) to non-invasive and then invasive lesions.
Flame detection method in video using covariance descriptors (2011)

Video fire detection system which uses a spatio-temporal covariance matrix of video data is proposed. This system divides the video into spatio-temporal blocks and computes covariance features extracted from these blocks to detect fire. Feature vectors taking advantage of both the spatial and the temporal characteristics of flame colored regions are classified using an SVM classifier which is trained and tested using video data containing flames and flame colored objects. Experimental results are presented.
<i>p</i>‐(Benzyloxy)calix[8]arene Synthesis Revisited: <i>p</i>‐(Benzyloxy)calix[4]‐, <i>p</i>‐(Benzyloxy)calix[5]‐, <i>p</i>‐(Benzyloxy)calix[7]‐, and <i>p</i>‐(Benzyloxy)bis(homooxa)calix[4]arenes (2010)

Abstract A detailed investigation of the 4‐(benzyloxy)phenol/formaldehyde reaction shows that along with the previously described p ‐(benzyloxy)calix[8]arene and p ‐(benzyloxy)calix[6]arene, others calixarenes are observed and easily recovered on a preparative scale. All these new calixarenes are opening interesting perspectives for the synthesis of new supramolecular hosts, easily functionalized at the para position under very mild conditions and/or exhibiting a deep hydrophobic pocket.
Synthesis and Antiviral Activity of (<i>Z</i>)- and (<i>E</i>)-2,2-[Bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines:  Second-Generation Methylenecyclopropane Analogues of Nucleosides (2003)

The second generation of methylenecyclopropane analogues of nucleosides 5a-5i and 6a-6i was synthesized and evaluated for antiviral activity. The 2,2-bis(hydroxymethyl)methylenecyclopropane (11) was converted to dibromo derivative 7 via acetate 12. Alkylation-elimination of adenine (16) with 7 afforded the Z/E mixture of acetates 17 + 18, which was deacetylated to give analogues 5a and 6a separated by chromatography. A similar reaction with 2-amino-6-chloropurine (19) afforded acetates 20 + 21 and, after deprotection and separation, isomers 5f and 6f. The latter served as starting materials for synthesis of analogues 5b, 5e, 5g-5i and 6b, 6e, 6g-6i. Alkylation-elimination of N(4)-acetylcytosine (22) with 7 afforded a mixture of isomers 5c + 6c which were separated via N(4)-benzoyl derivatives 23 and 24. Deprotection furnished analogues 5c and 6c. Alkylation of 2,4-bis(trimethylsilyloxy)-5-methylpyrimidine (25) with 7 led to bromo derivative 26. Elimination of HBr followed by deacetylation and separation gave thymine analogues 5d and 6d. The guanine Z-isomer 5b was the most effective against human and murine cytomegalovirus (HCMV and MCMV) with EC(50) = 0.27-0.49 microM and no cytotoxicity. The 6-methoxy analogue 5g was also active (EC(50) = 2.0-3.5 microM) whereas adenine Z-isomer 5a was less potent (EC(50) = 3.6-11.7 microM). Cytosine analogue 5c was moderately effective, but 2-amino-6-cyclopropylamino derivative 5e was inactive. All E-isomers were devoid of anti-CMV activity, and none of the analogues was significantly active against herpes simplex viruses (HSV-1 or HSV-2). The potency against Epstein-Barr virus (EBV) was assay-dependent. In Daudi cells, the E-isomers of 2-amino-6-cyclopropylamino- and 2,6-diaminopurine derivatives 6e and 6h were the most potent (EC(50) approximately 0.3 microM), whereas only the thymine Z-isomer 5d was active (EC(50) = 4.6 microM). Guanine Z-derivative 5b was the most effective compound in H-1 cells (EC(50) = 7 microM). In the Z-series, the 2-amino-6-methoxypurine analogue 5g was the most effective against varicella zoster virus (VZV, EC(50) = 3.3 microM) and 2,6-diaminopurine 5h against hepatitis B virus (HBV, EC(50) = 4 microM). Adenine analogues 5a and 6a were moderately active as substrates for adenosine deaminase.
Spherical Random Features for polynomial kernels (2015)

Compact explicit feature maps provide a practical framework to scale kernel methods to large-scale learning, but deriving such maps for many types of kernels remains a challenging open problem. Among the commonly used kernels for nonlinear classification are polynomial kernels, for which low approximation error has thus far necessitated explicit feature maps of large dimensionality, especially for higher-order polynomials. Meanwhile, because polynomial kernels are unbounded, they are frequently applied to data that has been normalized to unit l2 norm. The question we address in this work is: if we know a priori that data is normalized, can we devise a more compact map? We show that a putative affirmative answer to this question based on Random Fourier Features is impossible in this setting, and introduce a new approximation paradigm, Spherical Random Fourier (SRF) features, which circumvents these issues and delivers a compact approximation to polynomial kernels for data on the unit sphere. Compared to prior work, SRF features are less rank-deficient, more compact, and achieve better kernel approximation, especially for higher-order polynomials. The resulting predictions have lower variance and typically yield better classification accuracy.
A Proposed Method for the Analysis of Anionic Surfactants (1975)

The water industry is always in search of new and improved methods of chemical analyses of its product—potable water supplies. This article proposes a new procedure for the analysis of anionic surfactant discharges in wastewater effluents. The procedure has been found to be reliable for linear alkylate sulfonate analysis and is also proposed as a possible new standard method.
Speaker equipped with diaphragm filled with foamed resin (1985)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Shinichiro Kawamura, Takahiko Irimajiri; Speaker equipped with diaphragm filled with foamed resin. J. Acoust. Soc. Am. 1 September 1985; 78 (3): 1158. https://doi.org/10.1121/1.392952 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Deletion of CD2-Like (CD2v) and C-Type Lectin-Like (EP153R) Genes from African Swine Fever Virus Georgia-∆9GL Abrogates Its Effectiveness as an Experimental Vaccine (2020)

African swine fever virus (ASFV) is currently the most dreaded infectious disease affecting the global swine production industry. There is no commercial vaccine available, making the culling of infected animals the current solution to control outbreaks. Effective experimental vaccines have been developed by deleting virus genes associated with virulence. Deletion of the ASFV 9GL gene (∆9GL) has resulted in the attenuation of different ASFV strains, although the degree of attenuation varies across isolates. Here, we investigated the possibility of the increased safety of the experimental vaccine strain ASFV-G-Δ9GL by deleting two additional virus genes involved in pathogenesis, CD2v, a CD2 like viral encoded gene from the EP402R open reading frame (ORF), and C-type lectin-like viral gene, encoded from the EP153R ORF. Two new recombinant viruses were developed, ASFV-G-Δ9GL/ΔCD2v and ASFV-G-Δ9GL/ΔCD2v/ΔEP153R, harboring two and three gene deletions, respectively. ASFV-G-Δ9GL/ΔCD2v/ΔEP153R, but not ASFV-G-Δ9GL/ΔCD2v, had a decreased ability to replicate in vitro in swine macrophage cultures when compared with parental ASFV-G-Δ9GL. Importantly, ASFV-G-Δ9GL/ΔCD2v and ASFV-G-Δ9GL/ΔCD2v/ΔEP153R induced almost undetectable viremia levels when inoculated into domestic pigs and failed to protect them against challenge with parental virulent ASFV-Georgia, while ASFV-G-Δ9GL offered robust protection during challenge. Therefore, the deletion of CD2-like and C-type lectin-like genes significantly decreased the protective potential of ASFV-G-Δ9GL as a vaccine candidate. This study constitutes an example of the unpredictability of genetic manipulation involving the simultaneous deletion of multiple genes from the ASFV genome.
Simulated Body Fluid Nucleation of Three-Dimensional Printed Elastomeric Scaffolds for Enhanced Osteogenesis (2016)

Osseous tissue defects caused by trauma present a common clinical problem. Although traditional clinical procedures have been successfully employed, several limitations persist with regards to insufficient donor tissue, disease transmission, and inadequate host-implant integration. Therefore, this work aims to address current limitations regarding inadequate host tissue integration through the use of a novel elastomeric material for three-dimensional (3D) printing biomimetic and bioactive scaffolds. A novel thermoplastic polyurethane-based elastomeric composite filament (Gel-Lay) was used to manufacture porous scaffolds. In an effort to render the scaffolds more bioactive, the flexible scaffolds were subsequently incubated in simulated body fluid at various time points and evaluated for enhanced mechanical properties along with the effects on cell adhesion, proliferation, and 3-week osteogenesis. This work is the first reported use of a novel class of flexible elastomeric materials for the manufacture of 3D printed bioactive scaffold fabrication allowing efficient and effective nucleation of hydroxyapatite (HA) leading to increased nanoscale surface roughness while retaining the bulk geometry of the predesigned structure. Scaffolds with interconnected microfibrous filaments of ∼260 μm were created and nucleated in simulated body fluid that facilitated cell adhesion and spreading after only 24 h in culture. The porous structure further allowed efficient nucleation, exchange of nutrients, and metabolic waste removal during new tissue formation. Through the incorporation of osteoconductive HA, human fetal osteoblast adhesion and differentiation were greatly enhanced thus setting the tone for further exploration of this novel material for biomedical and tissue regenerative applications.
Linearization of phase-modulated analog optical links using a four-wave mixing comb source (2014)

We present a novel method for distortion elimination in phase-modulated analog optical links. A small part of the phase modulated signal seeds a four-wave mixing comb source, which generates lightwaves with integer multiples of the phase modulation of the original signal. These lightwaves are scaled and re-combined with the original phase-modulated signal to cancel the distortion generated in the interferometric phase-to-amplitude conversion process. Experimentally, we demonstrate full cancelation of the third-order distortion of the receiver and achieve a 19-dB improvement in the link's SFDR at a 1-Hz bandwidth. This approach is readily extendable to eliminate all relevant higher-order distortion products or synthesize arbitrary phase-to-amplitude transfer functions.
A Torque Based Sliding Mode Control of an Eddy Current Braking System for Automotive Applications (2005)

A sliding mode controller based on a polynomial-based eddy current machine model is presented in this paper. The controller provides a novel torque tracking control strategy that does not require any torque measurement. The enhanced parametric model captures the steady state torque-speed-current characteristics of the eddy current machine. The model parameters are experimentally estimated using a two stage least square type algorithm. Simulation of the proposed controller using a SIMULINK model incorporating the controller model, the eddy current brake model and a 14 degree of freedom vehicle model is performed. Simulation results are presented for the proposed controller in the context of an automobile braking application. The simulation results show good torque tracking performance of the proposed controller.
fast Monte Carlo sampler for NMR T2 inversion (2009)

The inversion of noisy NMR T2 echo data into a T2 spectrum is widely recognized as an inherently non-unique process [1]. One approach to quantifying this uncertainty is to use Monte Carlo sampling. Uncorrelated measurement noise combine with the non-negativity constraint on T2 spectral values to yield spectra following a non-negative normal distribution. There are two published samplers for truncated normal distributions [2], of which nonnegative normal samples are a subset, but we show that these converge too slowly to be practical for the T2 spectral inversion problem. This is because they are based on Gibbs’ samplers that update the spectral estimate just one T2 component at a time. When all of the spectral elements are fixed but one, that one has little room for change without violating the noise constraints on the data. Thus each spectral sample can only be slightly different from the preceding sample, indicating a high degree of statistical correlation and slow convergence. Our solution is to simultaneously update two neighboring spectral components at a time, allowing changes due to one spectral component to be offset by changes in its neighbor. Central to this improvement is a fast 2D slice sampler for non-negative normal distributions. This improves convergence by more than two orders of magnitude. Such speedup allows routine Monte Carlo inversion of 1D NMR spectra, and opens the door for the inversion of 2D NMR spectra.
Rank-modulation rewriting codes for flash memories (2013)

Current flash memory technology is focused on cost minimization of the stored capacity. However, the resulting approach supports a relatively small number of write-erase cycles. This technology is effective for consumer devices (smart-phones and cameras) where the number of write-erase cycles is small, however, it is not economical for enterprise storage systems that require a large number of lifetime writes. Our proposed approach for alleviating this problem consists of the efficient integration of two key ideas: (i) improving reliability and endurance by representing the information using relative values via the rank modulation scheme and (ii) increasing the overall (lifetime) capacity of the flash device via rewriting codes, namely, performing multiple writes per cell before erasure. We propose a new scheme that combines rank-modulation with rewriting. The key benefits of the new scheme include: (i) the ability to store close to 2 bits per cell on each write, and rewrite the memory close to q times, where q is the number of levels in each cell, and (ii) efficient encoding and decoding algorithms that use the recently proposed polar WOM codes.
Conceptual Design of a Multistage High-Speed Motor Driven Air Compressor (2008)

Centrifugal compressors operate with relatively high rotational speeds. A high rotational speed can be reached by a gearbox-coupled standard motor or by a high-speed motor with a frequency converter. The motivation for using high-speed motors is usually related to features like performance, size and total life cycle costs. A comparison of these features for the high-speed motor and gearbox driven air compressors are presented. The delivered pressure of oil-free plant air compressors is 600–900 kPa(g). Traditional gearbox driven turbo compressors have typically two or three compressor stages. In these machines, the cost impact for the additional stages is not as high as in the case of high-speed motor compressors, where only two stages can easily be coupled to one motor. The performance characteristics of a two-, three- and four-stage high-speed motor compressors are compared to each other. Based on the feasibility study, the two-stage compressor was selected for further analysis. The aim was to design a 250 kW plant air compressor. The optimization process to obtain the best performance for the compressor is discussed. This includes careful analysis of stage-specific speeds, electric motor performance, bearing performance, rotor dynamics, as well as material strengths and cooling. The predicted performance of the high-speed motor and compressor is presented.
A 14 kb/s wideband speech coder with a parametric highband model (2002)

This paper describes a new 14 kb/s wideband speech coder. The coder uses a split-band approach, where the input signal, sampled at 16 kHz, is split into two equal frequency bands from 0-4 kHz and 4-8 kHz, each of which is decimated to an 8 kHz sampling rate. The lower band is coded with a high-quality narrowband speech coder, the 11.8 kb/s G.729 Annex E, while the higher band is represented by a simple but effective parametric model. Two new features facilitate efficient coding of the high-band signal: noise modulation and high-frequency reversal. Since the encoding of the lower band is independent of the high-band signal, the narrowband encoder output can be embedded in the overall bitstream. Subjective test results show that this wideband speech coder is capable of producing high quality output speech.
Abstract 4512: A novel orally-bioavailable salicylic acid-based small molecular Stat3 inhibitor suppress growth of human breast tumor xenografts (2011)

Abstract With the critical role of aberrantly active Signal Transducer and Activator of Transcription (Stat) 3 protein in many human cancers, selective small molecular inhibitors targeting the dimerization event would be valuable as therapeutic agents and as chemical probes to clarify the complex biological functions of Stat3. By computational and structural analyses of the interaction between Stat3 and the lead dimerization disruptor, S3I-201.1066, we have designed a diverse set of analogs. We present evidence from in vitro studies that BP-1-102, a structural analog of S3I-201.1066, directly interacts with Stat3, with an affinity (KD) of 504 nM, inhibits in vitro Stat3 DNA-binding activity, with IC50 of 6.8 μM, and selectively inhibits Stat3 activity in human and mouse tumor cell lines that harbor constitutively-active Stat3. By contrast, BP-1-102 has little or no effect on pShc, pJak, pSrc, and pErk levels. Furthermore, BP-1-102 significantly and specifically suppressed the viability, proliferation, and survival of same malignant cell lines harboring aberrant Stat3 at low concentration, with little or no effect on normal NIH3T3 mouse fibroblasts or the mouse thymus epithelial stromal cells (TE-71) that do not harbor aberrant Stat3 activity. Furthermore, treatment of malignant cells harboring aberrant Stat3 activity with BP-1-102 down-regulated the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, and VEGF, which are known Stat3-regulated genes. These results together strongly suggest the anti-tumor cell effects of BP-1-102 is largely dependent on the inhibition of aberrant Stat3 activity. Significantly, BP-1-102 induced strong antitumor response in mouse xenografts of human breast cancer when administered via intravenous or oral gavage. Our studies identify a novel small-molecule that binds with a high affinity to Stat3 and that blocks Stat3 activation and function, and thereby induces antitumor response in human breast tumor xenografts harboring aberrant Stat3. Key Words: Stat3 inhibitor, antitumor, xenograft, BP-1-102, S3I-201.1066 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4512. doi:10.1158/1538-7445.AM2011-4512
Limits of detection of antibody pairs to detect DENV Serotype. (2020)

<p>The limits of detection (LoD) and dissociation constant (K<sub>d</sub>) were calculated for each antibody pair for the detection of its respective dengue serotype using ELISA (a) and dipstick (b) formats.</p> <p>(DOCX)</p>