gebhart/patrepeval huggingface dataset:
A comparative study of different deployment modes for femtocell networks (2009)

Femtocell networks have the potential of significantly improving the capacity of next-generation cellular systems. However, interference to/from the macrocell network is a critical problem affecting the capacity. Co-channel operation with closed-subscriber group (CSG) access offers a large bandwidth to be shared by the users of the femtocell network; however, it also introduces significant interference to/from the macrocell network. On the other hand, femtocell networks using dedicated spectrum assignment and open access mode have insignificant interference concerns, with the trade-off of available spectrum limitations. In this study, we investigate interference vs. bandwidth tradeoffs in different types of femtocell network deployments through the help of channel capacity formulations. Related downlink simulation results are provided to compare the capacities of different deployment modes and the impact of key system parameters.
Production of Recombinant Human Pancreatic Secretory Trypsin Inhibitor by Escherichia coli (1987)

A synthetic gene for human pancreatic secretory trypsin inhibitor (PSTI) was fused to the coding sequence for the amino-terminal 135 amino acid residues of human interferon-gamma (IFN-gamma) by interposing a methionine codon sequence, and the resulting hybrid gene was efficiently expressed in Escherichia coli cells. Recombinant human PSTI (rHu-PSTI) was separated from the IFN-gamma/PSTI fused protein by cleavage at the methionine residue with cyanogen bromide. Finally, rHu-PSTI was purified by affinity chromatography on a bovine trypsin-CH-Sepharose 4B column. The amino acid composition, partial amino-terminal sequence, disulfide formation, human trypsin inhibitory activity, and immunoreactivity against rabbit anti-human PSTI serum of rHu-PSTI corresponded to those of the natural form.
Sequit: software for <i>de novo</i> peptide sequencing by matrix‐assisted laser desorption/ionization post‐source decay mass spectrometry (2004)

Peptide sequencing by mass spectrometry is gaining increasing importance for peptide chemistry and proteomics. However, available tools for interpreting matrix-assisted laser desorption/ionization post-source decay (MALDI-PSD) mass spectra depend on databases, and identify peptides by matching experimental data with spectra calculated from database sequences. This severely obstructs the identification of proteins and peptides not listed in databases or of variations, e.g. mutated proteins. The development of a new computer program for database-independent peptide sequencing by MALDI-PSD mass spectrometry is reported here. This computer program was validated by the determination of the correct sequences for various peptides including sequences listed in the sequence databases, but also for peptides that deviate from database sequences or are completely artificial. This strategy should substantially facilitate the identification of novel or variant peptides and proteins, and increase the power of MALDI-PSD analyses in proteomics.
Ruthenium-based olefin metathesis catalysts bearing new N-heterocyclic carbenes (2005)

Olefin metathesis catalysts based on the L2X2Ru=CHR scaffold have contributed\nsignificantly to the expanding spectrum of olefin metathesis applications. Recent\nwork has shown that catalysts bearing an N-heterocyclic carbene (NHC) ligand\nexhibit enhancecl metathesis activity over previous ruthenium-based catalysts.\nThe synthesis and activity of olefin metathesis catalysts containing new NHC\nligands will be presented.
Quantum pattern recognition with liquid-state nuclear magnetic resonance (2009)

A quantum pattern recognition scheme is presented, which combines the idea of a classic Hopfield neural network with adiabatic quantum computation. Both the input and the memorized patterns are represented by means of the problem Hamiltonian. In contrast to classic neural networks, the algorithm can return a quantum superposition of multiple recognized patterns. A proof of principle for the algorithm for two qubits is provided using a liquid-state NMR quantum computer.
Reducing dynamin 2 (DNM2) rescues <i>DNM2</i> -related dominant centronuclear myopathy (2018)

Centronuclear myopathies (CNM) are a group of severe muscle diseases for which no effective therapy is currently available. We have previously shown that reduction of the large GTPase DNM2 in a mouse model of the X-linked form, due to loss of myotubularin phosphatase MTM1, prevents the development of the skeletal muscle pathophysiology. As <i>DNM2</i> is mutated in autosomal dominant forms, here we tested whether DNM2 reduction can rescue <i>DNM2</i>-related CNM in a knock-in mouse harboring the p.R465W mutation (<i>Dnm2</i><sup>RW/+</sup>) and displaying a mild CNM phenotype similar to patients with the same mutation. A single intramuscular injection of adeno-associated virus-shRNA targeting <i>Dnm2</i> resulted in reduction in protein levels 5 wk post injection, with a corresponding improvement in muscle mass and fiber size distribution, as well as an improvement in histopathological CNM features. To establish a systemic treatment, weekly i.p. injections of antisense oligonucleotides targeting <i>Dnm2</i> were administered to <i>Dnm2</i><sup>RW/+</sup>mice for 5 wk. While muscle mass, histopathology, and muscle ultrastructure were perturbed in <i>Dnm2</i><sup>RW/+</sup>mice compared with wild-type mice, these features were indistinguishable from wild-type mice after reducing DNM2. Therefore, DNM2 knockdown via two different strategies can efficiently correct the myopathy due to <i>DNM2</i> mutations, and it provides a common therapeutic strategy for several forms of centronuclear myopathy. Furthermore, we provide an example of treating a dominant disease by targeting both alleles, suggesting that this strategy may be applied to other dominant diseases.
A 240 × 180 130 dB 3 µs Latency Global Shutter Spatiotemporal Vision Sensor (2014)

Event-based dynamic vision sensors (DVSs) asynchronously report log intensity changes. Their high dynamic range, sub-ms latency and sparse output make them useful in applications such as robotics and real-time tracking. However they discard absolute intensity information which is useful for object recognition and classification. This paper presents a dynamic and active pixel vision sensor (DAVIS) which addresses this deficiency by outputting asynchronous DVS events and synchronous global shutter frames concurrently. The active pixel sensor (APS) circuits and the DVS circuits within a pixel share a single photodiode. Measurements from a 240×180 sensor array of 18.5 μm 2 pixels fabricated in a 0.18 μm 6M1P CMOS image sensor (CIS) technology show a dynamic range of 130 dB with 11% contrast detection threshold, minimum 3 μs latency, and 3.5% contrast matching for the DVS pathway; and a 51 dB dynamic range with 0.5% FPN for the APS readout.
Perovskite electron emitters: Computational prediction and preliminary experimental assessment of novel low work function cathodes (2018)

Our recent computational discovery of SrVO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> possessing a low work function has spurred a much larger modeling effort to search for additional, new perovskite compounds with low work function for applications as thermionic electron emitting cathodes. Here, we detail our progress of conducting high-throughput Density Functional Theory calculations on a set of ~3100 perovskite compounds. We found numerous perovskite materials which possess a low predicted work function and adequate stability under typical operating conditions. Further, we completed preliminary experimental high temperature emission testing of pure SrVO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> . These early, non-optimized test results support SrVO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> 's promise as a novel electron emission material.
The combustion synthesis of boride composites. [B/sub 4/C/TiB/sub 2/ infiltrated with Al] (1987)

We have investigated the combustion synthesis process as a means of producing hard, tough, lightweight B/sub 4/c/TiB/sub 2/ composites. We based our experimental program on thermodynamic calculations. Adiabatic temperatures and product compositions were determined on the basis of the stoichiometry and initial temperature of the reactants. For lightweight products the composition must be relatively rich in the B/sub 4/C component. We found that B/sub 4/C-rich composites could only be obtained by increasing the initial temperature of the reactants. The product is a hard, porous material whose toughness should be enhanced by filling the pores with aluminum using a liquid-metal infiltration process. 9 figs., 3 tabs.
Synthetic urokinase inhibitors as potential anti-invasive drugs. (2001)

In carcinogenesis, proteinases play an important role in metastasis of solid malignant tumors. Aside from several matrix metalloproteinases and cathepsins, the urokinase-plasmin system seems to be one of the main players within the cell surface-associated proteolytic activity, facilitating tumor cell migration and invasion. Upon binding to a specific receptor, the enzymatic activity of urokinase is focused to the cell surface. The significance of the plasminogen activator system in malignancy is underlined by the finding of elevated levels of urokinase and its receptor in tumor tissues. Therefore, the possible use of urokinase inhibitors in the therapeutic treatment of cancer and metastasis has been the subject of intensive investigations. This review covers synthetic inhibitors of urokinase described up to December 2000, although the number of lead structures is still relatively small.
Abstract 2594: Adjuvant cationic nanoliposomes induce anti-cancer immunity in a murine model of breast cancer (2014)

Abstract Nanoparticles, such as liposomes, provide opportunities to simultaneously present antigens and immune modulators. Using a 4T1 murine model of breast cancer, a cationic nanoliposomal formulation containing monophosphoryl lipid A and the cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane induced anti-tumor activity following intratumoral administration. Addition of recombinant interleukin-12 (IL-12) further suppressed tumor growth and augmented T helper-1 cell (Th-1) polarization, with enhanced tumor infiltration by cytotoxic T cells, dendritic cells, and M1 macrophages, and amplification of interferon gamma secretion. Mice bearing dual tumors displayed arrest of tumor growth in treated tumors as well as distal, untreated tumors following combination therapy with adjuvant nanoliposomes and IL-12. In summary, adjuvant MPL-liposomes combined with localized IL-12 therapy block tumor growth, stimulate a Th-1 bias of the tumor microenvironment, and induce cancer-specific immune responses. Citation Format: Ismail M. Meraz, David J. Savage, Jianhua Gu, Jessica Rhudy, Rita E. Serda. Adjuvant cationic nanoliposomes induce anti-cancer immunity in a murine model of breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2594. doi:10.1158/1538-7445.AM2014-2594
Porcine circovirus type 2 and associated diseases in Romania — Short communication (2007)

Porcine circovirus type 2 (PCV2) has been demonstrated to be the causal agent for postweaning multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS). This report describes the first detection of PCV2 and associated diseases in a Romanian swine herd located in Transylvania. The clinical signs, pathological and histopathological changes observed in affected pigs were similar to those previously described for PDNS and PMWS. Polymerase chain reaction and in situ hybridisation were used for the detection of PCV2 nucleic acids from tissues and serum samples. Complete PCV2 genomes of both PMWS and PDNS cases were sequenced and analysed, and by comparing them with each other no genomic differences could be detected. The sequence analysis showed that the Romanian PCV2 was closely related to PCV2 identified in France and in Hungary.
Quantitative radiography enabled by slot collimation and a novel scatter correction technique on a large-area flat panel x-ray detector (2009)

In addition to causing loss of contrast and blurring in an image, scatter also makes quantitative measurements of xray attenuation impossible. Many devices, methods, and models have been developed to eliminate, estimate, and correct for the effects of scatter. Although these techniques can reduce the impact of scatter in a large-area image, no methods have proven to be practical and sufficient to enable quantitative analysis of image data in a routine clinical setting. This paper describes a method of scatter correction which uses moderate x-ray collimation in combination with a correction algorithm operating on data obtained from large-area flat panel detector images. The method involves acquiring slot collimated images of the object, and utilizing information from outside of the collimated region, in addition to a priori data, to estimate the scatter within the collimated region. This method requires no increase dose to the patient while providing high image quality and accurate estimates of the primary x-ray data. This scatter correction technique was validated through beam stop experiments and comparison of theoretically calculated and measured contrast of thin aluminum and polymethylmethacrelate objects. Measurements taken with various background material thicknesses, both with and without a grid, showed that the slot-scatter corrected contrast and the theoretical contrast were not significantly different given a 99% confidence interval. However, the uncorrected contrast was found to be significantly different from the corrected and theoretical contrasts. These findings indicate that this method of scatter correction can eliminate the effect of scatter on contrast and potentially enable quantitative x-ray imaging.
<title>Improving the efficiency and stability of organic light-emitting devices using mixed emitting layers</title> (1998)

We studied an organic light emitting device (OLED) involving electroluminescence from a mixed layer consisting of a hole transport material (HTM) and an emitting electron transport material (ETM) and including thin electron and hole injection contacts. A naphthyl-substituted benzidine derivative (NPB) and tris (8-hydroxyquinoline) aluminum (ALQ<SUB>3</SUB>) are used as the HTM and the emitting ETM, respectively. Following a control-experiment approach, the efficiency and the operational lifetime of OLEDs adopting the new structure are compared to those of conventional bilayer devices made of the same materials and fabricated under the same conditions. Efficiency is calculated from the luminance-current density-voltage characteristics. Lifetime tests are carried at constant current density in dry air. Photoluminescence is used to detect changes in the quantum efficiency of the ALQ<SUB>3</SUB> on mixing with the HTL. Compared to a conventional bilayer device, the new device structure leads to approximately 50 percent higher efficiency and an order of magnitude increase in the operational lifetime. The higher efficiency is attributed to (i) reduced leakage of charge carrier to the electrodes, (ii) exciton confinement away from the metal cathode, and (iii) higher quantum efficiency of the emitting electron transport material due to mixing with the hole transport material. Possible reasons for the higher stability are also discussed.
Formation of synthetic images on a laser-beam-adressed smectic liquid-crystal display (1975)

The reproduction and the storage of synthetic images on a smectic liquid-crystal display is described. The ‘write’ is obtained by an infrared laser beam. A spatial modulation of the cell transmission is obtained with a variable alternating voltage applied to the cell. A high-resolution display with high contrast and continuous gray scale was realised.
Synthesis and characterization of fluorinated phosphonium ionic liquids (2007)

A wide variety of phosphonium ionic liquids containing fluorous ponytails R f n (R f n = –(CF 2 ) n –1 CF 3 ; n = 4, 6, 10) are synthesized by the reaction of R f n -(CH 2 ) 2 -I with trialkylphosphines (R 3 P; R = Me, n Bu, n Oct). The efficacy of multiple metathetical routes to anion exchange have been investigated, thus the corresponding BF 4 – , PF 6 – , tosylate (OTs – ) and triflate (OTf – ) derivatives have also been prepared. All compounds have been comprehensively characterized by multinuclear NMR spectroscopy, ESI-MS, DSC, and TGA/SDTA, and in the case of [Me 3 PCH 2 CH 2 R f4 ][I] by single crystal X-ray diffraction. These materials range from high melting solids (e.g., [Me 3 P(CH 2 ) 2 R f4 ][I] T m = 195 °C) to very low melting liquids (e.g., [ n Oct 3 P(CH 2 ) 2 R f4 ][OTf] T g = –64 °C), and they all have high thermal decomposition points (295 to 394 °C). Incorporation of the more weakly coordinating BF 4 – and PF 6 – yielded a significant increase in the melting point of the materials, in contrast to OTf – and OTs – derivatives, which all exhibited significantly depressed melting points.Key words: phosphonium ionic liquids, alternative solvents, fluorine, phosphorus, fluorous ponytails.
Predictive Impact Analysis for Designing a Resilient Cellular Backhaul Network (2018)

Backhaul transport network design and optimization for cellular service providers involve a unique challenge stemming from the fact that an end-user's equipment (UE) is within the radio reach of multiple cellular towers: It is hard to evaluate the impact of the failure of the UE's primary serving tower on the UE, because the UE may simply switch to get service from other nearby cellular towers. To overcome this challenge, one needs to quantify the cellular service redundancy among the cellular towers riding on that transport circuit and their nearby cellular towers, which in turn requires a comprehensive understanding of the radio signal profile in the area of the impacted towers, the spatial distribution of UEs therein, and their expected workload (e.g., calls, data throughput). In this work, we develop a novel methodology for assessing the service impact of any hypothetical cellular tower outage scenario, and implement it in an operational system named Tower Outage Impact Predictor (TOIP). Our evaluations, using both synthetic data and historical real tower outages in a large operational cellular network, show conclusively that TOIP gives an accurate assessment of various tower outage scenarios, and can provide critical input data towards designing a reliable cellular backhaul transport network.
Post-Stroke Rehabilitation with the Rutgers Ankle System: A Case Study (2001)

The “Rutgers Ankle” is a Stewart platform-type haptic interface designed for use in rehabilitation. The system supplies six-degree-of-freedom (DOF) resistive forces on the patient's foot, in response to virtual reality-based exercises. The Rutgers Ankle controller contains an embedded Pentium board, pneumatic solenoid valves, valve controllers, and associated signal conditioning electronics. The rehabilitation exercise used in our case study consists of piloting a virtual airplane through loops. The exercise difficulty can be selected based on the number and placement of loops, the airplane speed in the virtual environment, and the degree of resistance provided by the haptic interface. Exercise data is stored transparently, in real time, in an Oracle database. These data consist of ankle position, forces, and mechanical work during an exercise, and over subsequent rehabilitation sessions. The number of loops completed and the time it took to do that are also stored online. A case study is presented of a patient nine months post-stroke using this system. Results showed that, over six rehabilitation sessions, the patient improved on clinical measures of strength and endurance, which corresponded well with torque and power output increases measured by the Rutgers Ankle. There were also substantial improvements in task accuracy and coordination during the simulation and the patient's walking and stair-climbing ability.
Peroral transgastric endoscopic primary repair of a ventral hernia in a porcine model (2007)

Transgastric endoscopic primary repair of ventral hernias in a porcine model is feasible and may be technically simpler than laparoscopic surgery.
A process for the simultaneous oligomerization and copolymerization of ethylene (1988)

Abstract High density polyethylene becomes more flexible and tough by adding short branches onto the otherwise linear backbone. Commercially, this is achieved by adding 1‐butene or 1‐hexene comonomer to reactor and copolymerizing it with ethylene. A process has now been developed which uses low pressure to produce new forms of branched polyethylene without addition of comonomer to the reaction mixture.
Rapid Discovery of Pyrido[3,4-<i>d</i>]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach (2016)

Monopolar spindle 1 (MPS1) plays a central role in the transition of cells from metaphase to anaphase and is one of the main components of the spindle assembly checkpoint. Chromosomally unstable cancer cells rely heavily on MPS1 to cope with the stress arising from abnormal numbers of chromosomes and centrosomes and are thus more sensitive to MPS1 inhibition than normal cells. We report the discovery and optimization of a series of new pyrido[3,4-d]pyrimidine based inhibitors via a structure-based hybridization approach from our previously reported inhibitor CCT251455 and a modestly potent screening hit. Compounds in this novel series display excellent potency and selectivity for MPS1, which translates into biomarker modulation in an in vivo human tumor xenograft model.
Dynamic range enhancement of RF rectifiers through adaptive power distribution employing an extended resonance network (2015)

This paper presents an extended resonance power divider to increase the dynamic range of RF rectifiers. Such a power divider distributes the RF input power among several different rectifier cells adaptively based on the input power level. Therefore, high rectification efficiency can be maintained over a very wide dynamic range. As a proof of concept, a two-way dynamic enhancement rectifier network has been designed, which exhibits a rectification efficiency greater than 50% within a dynamic range of 35 dB (from -15 dBm to 20 dBm).
Noise reduction for dual-microphone mobile phones exploiting power level differences (2012)

This paper discusses the application of noise reduction algorithms for dual-microphone mobile phones. An analysis of the acoustical environment based on recordings with a dual-microphone mock-up phone mounted on a dummy head is given. Motivated by the recordings, a novel dual-channel noise reduction algorithm is proposed. The key components are a noise PSD estimator and an improved spectral weighting rule which both explicitly exploit the Power Level Differences (PLD) of the desired speech signal between the microphones. Experiments with recorded data show that this low complexity system has a good performance and is beneficial for an integration into future mobile communication devices.