gebhart/patrepeval huggingface dataset:
Ciliary Neurotrophic Factor Promotes the Activation of Corneal Epithelial Stem/Progenitor Cells and Accelerates Corneal Epithelial Wound Healing (2014)

Ciliary neurotrophic factor (CNTF), a well-known neuroprotective cytokine, has been found to play an important role in neurogenesis and functional regulations of neural stem cells. As one of the most innervated tissue, however, the role of CNTF in cornea epithelium remains unclear. This study was to explore the roles and mechanisms of CNTF in the activation of corneal epithelial stem/progenitor cells and wound healing of both normal and diabetic mouse corneal epithelium. In mice subjecting to mechanical removal of corneal epithelium, the corneal epithelial stem/progenitor cell activation and wound healing were promoted by exogenous CNTF application, while delayed by CNTF neutralizing antibody. In cultured corneal epithelial stem/progenitor cells, CNTF enhanced the colony-forming efficiency, stimulated the mitogenic proliferation, and upregulated the expression levels of corneal epithelial stem/progenitor cell-associated transcription factors. Furthermore, the promotion of CNTF on the corneal epithelial stem/progenitor cell activation and wound healing was mediated by the activation of STAT3. Moreover, in diabetic mice, the content of CNTF in corneal epithelium decreased significantly when compared with that of normal mice, and the supplement of CNTF promoted the diabetic corneal epithelial wound healing, accompanied with the advanced activation of corneal epithelial stem/progenitor cells and the regeneration of corneal nerve fibers. Thus, the capability of expanding corneal epithelial stem/progenitor cells and promoting corneal epithelial wound healing and nerve regeneration indicates the potential application of CNTF in ameliorating limbal stem cell deficiency and treating diabetic keratopathy.
Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway (2009)

Since the discovery of NAD-dependent deacetylases, sirtuins, it has been recognized that maintaining intracellular levels of NAD is crucial for the management of stress response of cells. Here we show that agonist-induced cardiac hypertrophy is associated with loss of intracellular levels of NAD, but not exercise-induced physiologic hypertrophy. Exogenous addition of NAD was capable of maintaining intracellular levels of NAD and blocking the agonist-induced cardiac hypertrophic response in vitro as well as in vivo. NAD treatment blocked the activation of pro-hypertrophic Akt1 signaling, and augmented the activity of anti-hypertrophic LKB1-AMPK signaling in the heart, which prevented subsequent induction of mTOR-mediated protein synthesis. By using gene knock-out and transgenic mouse models of SIRT3 and SIRT1, we showed that the anti-hypertrophic effects of exogenous NAD are mediated through activation of SIRT3, but not SIRT1. SIRT3 deacetylates and activates LKB1, thus augmenting the activity of the LKB1-AMPK pathway. These results reveal a novel role of NAD as an inhibitor of cardiac hypertrophic signaling, and suggest that prevention of NAD depletion may be critical in the treatment of cardiac hypertrophy and heart failure.
Startup: A Silicon Valley Adventure (1995)

From the Publisher:
Kaplan, a well-known figure in the computer industry, founded GO Corporation in 1987, and for several years it was one of the hottest new ventures in the Valley. Startup tells the story of Kaplan's wild ride: how he assembled a brilliant but fractious team of engineers, software designers, and investors; pioneered the emerging market for hand-held computers operated with a pen instead of a keyboard; and careened from crisis to crisis without ever losing his passion for a revolutionary idea. Along the way, Kaplan vividly recreates his encounters with eccentric employees, risk-addicted venture capitalists, and industry giants such as Bill Gates, John Sculley, and Mitchell Kapor. And no one - including Kaplan himself - is spared his sharp wit and observant eye.
What's new in female sterilization? The silicone tubal plug is. (1982)

A new female sterilization procedure, the RSP Hysteroscopic Silicone tubal occlusion Procedure, developed at the Franklin Research Center in Philadelphia, Pennsylvania, is described in this article, and the author's experience with this technique is reviewed. In this procedure a small amount of liquid silicone is injected into the fallopian tubes where it solidifies. The injection is done under direct vision through a hysteroscope. There are few contraindications. The tubal occlusion procedure is accomplished in an office setting using a paracervical block for anesthesia. A hysteroscope is introduced into the uterus and the uterine cavity distended with a 32% dextran 70 (Hyskon). The cavity is viewed, and the tubal ostium identified. An attempt is made to determine patency of the tubes by observing the outflow of Hyskon through the tubal ostium. Then a catheter guide is placed through the hysteroscope and inserted into the tubal ostium. On the tip of this guide is a preformed silicone tip with an attached retrieval loop. Parallel axis must be achieved before the installation of silicone. Once parallel axis has been obtained, catalyst is added to the silicone syringe and is mixed in a precise fashion and within a specific time. The syringe is then placed into the fluid flow acuation system which injects under high pressure the small amount of silicone used. From June 1981 through March 1982 the author performed a hysteroscopic tubal occlusion on 73 patients. 14 of these 73 patients had a 2nd procedure because only a single plug was inserted on the initial attempt. The range for the times of the initial procedures was from 24-130 minutes; the mean time was 45 minutes. Bilateral normal plugs have been inserted into 67 of the 73 patients (91.8%). In order to achieve the 67 bilaterally normal plugs 14 patients (19.2%) required a repeat procedure. 3 more patients need, but have not yet had, a 2nd procedure. Bilateral plugs were actually inserted into a higher percentage of patients, but some plugs were not normal and had to be replaced. The causes for the inability to insert a bilateral plug during the 1st procedure are listed. The most common cause was the inability to obtain parallel axis. Problems will always occur with this procedure, but it would seem that with more experience and better equipment, a sterilization rate at a time of the 1st procedure should be accomplished in better than 90% of the patients and when a 2nd procedure is used, a better than 95% success rate should be achievable.
Meta-Search In Human Resource Management (2007)

In the area of Human Resource Management, the trend is towards online exchange of information about human resources. For example, online applications for employment become standard and job offerings are posted in many job portals. However, there are too many job portals to monitor all of them if someone is interested in a new job. We developed a prototype for integrating information of different job portals into one meta-search engine. First, existing job portals were investigated and XML schema documents were derived automated from these portals. Second, translation rules for transforming each schema to a central HR-XML-conform schema were determined. The HR-XML-schema is used to build a form for searching jobs. The data supplied by a user in this form is now translated into queries for the different job portals. Each result obtained by a job portal is sent to the meta-search engine that ranks the result of all received job offers according to user's preferences.
<i>o</i>‐Amine‐Assisted Cannizzaro Reaction of Glyoxal with New 2,6‐Diaminoanilines (2009)

Abstract The preparation of several new o ‐amine‐substituted anilines was achieved according to a new bifunctional molecular design, and their reactions with glyoxal were conducted. Cannizzaro reactions of glyoxal proceeded using specifically designed anilines, such as 2,6‐dipyrrolidinyl‐, 2,6‐dipiperidinyl‐, 2,6‐dimorpholinyl‐, and 2‐pyrrolidinyl‐aniline, which are new and can easily be synthesized by substitution of halogen‐substituted nitrobenzene with amines and subsequent reduction with hydrogen, to form α‐hydroxy acetamide and α‐amino acetamide derivatives, as a result of the Cannizzaro reaction. In comparison with the reaction of glyoxal with p ‐pyrrolidinylaniline to form a common diimine product, the reaction with o ‐pyrrolidinylaniline leads only to α‐hydroxy amides, strongly suggesting that the abnormal Cannizzaro reactions are attributed to the existence of basic nitrogen atoms at the o ‐positions, which suppress diimine formation and assist the generation of acetamides.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Robust watermarking of still images for copyright protection (2002)

Digital watermarking has been proposed as a means to protect the copyright of multimedia data in a networked environment, since it makes it possible to tightly embed a code into a digital document allowing the identification of the data owner. A new watermarking system for digital images is presented: the method embeds a sequence of random real numbers in a selected set of DCT coefficients. Embedding is performed by exploiting the masking characteristics of the human visual system, to ensure the watermark invisibility. The embedded sequence can be extracted without resorting to the original uncorrupted image. Experimental results demonstrate that the watermark is robust to several signal processing techniques and geometric distortions.
Novel visual‐cue‐based sticky traps for monitoring of emerald ash borers,<i>Agrilus planipennis</i>(Col., Buprestidae) (2008)

Abstract We examined various methods of trapping emerald ash borers (EAB), Agrilus planipennis Fairmaire, using solely visual cues based on previous work that has documented the importance of visual cues in EAB mate location. Here, we give the results of two of these methods, coloured sticky cards (yellow or blue), or live ash leaves covered with spray‐on adhesive to which dead male EAB visual lures had been pinned. Feral male beetles were captured effectively on the sticky traps made from dead male EAB on ash leaves. These sticky‐leaf‐traps captured more male EAB when deployed in high‐population density areas than low‐density areas, but did capture EAB even at lower population densities. More feral males were captured on these traps when they were placed higher in the trees, regardless of the population density of EAB. Very few feral female EAB were captured using the sticky‐leaf‐traps. This novel method of EAB trapping may allow ‘real‐time’ population detection and monitoring of EAB adults during the active flight period rather than locating larval galleries during the autumn and winter after adult flight and attack. Feral male beetles were also captured using standard yellow‐ or blue‐coloured sticky cards to which male EAB had been affixed with adhesive; however, this type of trap was much less effective overall than using the sticky‐leaf‐traps. Furthermore, Agrilus cyanescens , a species similar in colour to EAB but smaller in size, showed a strong response to blue‐coloured sticky traps to which dead male EAB had been affixed with adhesive, suggesting a general use of visual cues in the mating systems of some of the other Buprestidae as well.
Node Selection in Cooperative Wireless Networks (2009)

In this thesis, we argue for node selection in cooperative decode-and-forward networks. In a single-hop network with multiple relays, we show that selecting a single node to aid in the transmission between a source and a destination outperforms both traditional orthogonal transmissions and distributed space-time codes. In networks where sources transmit information over multiple hops and relays can communicate with each other, we study the relationship between cooperation and channel-adaptive routing. We show that cooperation is only beneficial if designed jointly with a routing scheme. This motivates a search for optimal algorithms in generalized relay networks. In networks without restrictions on the relays in terms of whom they can communicate with, we study the problem of optimal resource allocation in terms of transmission time. The resource allocation selects the relays to participate in the transmission and optimally allocates time resource between the selected relays. To implement this resource allocation algorithm, we propose a recursive solution which reduces the computational complexity of the algorithm. For large networks, the resulting computational complexity of implementing the algorithm is exponential in the size of the network and is likely to preclude its implementation. We thus propose that the resource allocation be implemented sub-optimally through node selection: a subset of the nodes in the network should be selected and used as input to the optimal resource allocation algorithm. We provide guidelines for selecting the nodes and propose four heuristics which offer various complexity-performance trade-offs. Compared to the optimal resource algorithm, all four heuristics significantly decrease the required computation complexity of the optimal algorithm.
Copper Bronze Catalyzed Heck Reaction in Ionic Liquids (2005)

Heck reaction of aryl iodides and activated aryl bromides catalyzed by copper bronze in tetrabutylammonium bromide as solvent and tetrabutylammonium acetate as base was developed. The effective catalysts are Cu nanoparticles deriving from the reaction of iodobenzene with copper bronze. These nanoparticles are very stable in tetraalkylammonium salts, are easily recycled, and can be stored for months without a loss of catalytic efficiency. [reaction: see text]
Short-wavelength stimulated Raman scattering in a silica fiber pumped by an XeBr excimer laser (1989)

A UV-grade silica optical fiber was pumped by a 281.8-nm XeBr excimer laser. The first Stokes spectrum was observed at 285 nm. The spectral width was one-half of that of the spontaneous Raman spectrum. A numerical analysis of stimulated Raman scattering which includes two-photon absorption loss is presented. The Raman gain coefficient, determined by an analysis of the nonlinearity observed in the Stokes output, was 1.8*10/sup -5/ cm/MW. The analysis also indicates that two-photon absorption is a more important loss factor than linear attenuation. The short wavelength limit of net amplification by stimulated Raman scattering is estimated to be 272 nm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Floating-Point Numbers with Error Estimates (revised) (2012)

The study addresses the problem of precision in floating-point (FP) computations. A method for estimating the errors which affect intermediate and final results is proposed and a summary of many software simulations is discussed. The basic idea consists of representing FP numbers by means of a data structure collecting value and estimated error information. Under certain constraints, the estimate of the absolute error is accurate and has a compact statistical distribution. By monitoring the estimated relative error during a computation (an ad-hoc definition of relative error has been used), the validity of results can be ensured. The error estimate enables the implementation of robust algorithms, and the detection of ill-conditioned problems. A dynamic extension of number precision, under the control of error estimates, is advocated, in order to compute results within given error bounds. A reduced time penalty could be achieved by a specialized FP processor. The realization of a hardwired processor incorporating the method, with current technology, should not be anymore a problem and would make the practical adoption of the method feasible for most applications.
Knowledge Graph Representation with Jointly Structural and Textual Encoding (2017)

The objective of knowledge graph embedding is to encode both entities and relations of knowledge graphs into continuous low-dimensional vector spaces. Previously, most works focused on symbolic representation of knowledge graph with structure information, which can not handle new entities or entities with few facts well. In this paper, we propose a novel deep architecture to utilize both structural and textual information of entities. Specifically, we introduce three neural models to encode the valuable information from text description of entity, among which an attentive model can select related information as needed. Then, a gating mechanism is applied to integrate representations of structure and text into a unified architecture. Experiments show that our models outperform baseline and obtain state-of-the-art results on link prediction and triplet classification tasks.
Multiple Functions of the New Cytokine-Based Antimicrobial Peptide Thymic Stromal Lymphopoietin (TSLP) (2016)

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine, hitherto mostly known to be involved in inflammatory responses and immunoregulation. The human tslp gene gives rise to two transcription and translation variants: a long form (lfTSLP) that is induced by inflammation, and a short, constitutively-expressed form (sfTSLP), that appears to be downregulated by inflammation. The TSLP forms can be produced by a number of cell types, including epithelial and dendritic cells (DCs). lfTSLP can activate mast cells, DCs, and T cells through binding to the lfTSLP receptor (TSLPR) and has a pro-inflammatory function. In contrast, sfTSLP inhibits cytokine secretion of DCs, but the receptor mediating this effect is unknown. Our recent studies have demonstrated that both forms of TSLP display potent antimicrobial activity, exceeding that of many other known antimicrobial peptides (AMPs), with sfTSLP having the strongest effect. The AMP activity is primarily mediated by the C-terminal region of the protein and is localized within a 34-mer peptide (MKK34) that spans the C-terminal α-helical region in TSLP. Fluorescent studies of peptide-treated bacteria, electron microscopy, and liposome leakage models showed that MKK34 exerted membrane-disrupting effects comparable to those of LL-37. Expression of TSLP in skin, oral mucosa, salivary glands, and intestine is part of the defense barrier that aids in the control of both commensal and pathogenic microbes.
In Vitro Repression of Brca1-associated RING Domain Gene, <i>Bard1</i>, Induces Phenotypic Changes in Mammary Epithelial Cells (1998)

BRCA1-associated RING domain (BARD1) was identified as a protein interacting with the breast cancer gene product BRCA1. The identification of tumorigenic missense mutations within BRCA1 that impair the formation of BARD1-BRCA1 complexes, and of BARD1 mutations in breast carcinomas, sustain the view that BARD1 is involved in BRCA1-mediated tumor suppression. We have cloned the murine Bard1 gene and determined that its expression in different tissues correlates with the expression profile of Brca1. To investigate the function of Bard1, we have reduced Bard1 gene expression in TAC-2 cells, a murine mammary epithelial cell line that retains morphogenetic properties characteristic of normal breast epithelium. Partial repression of Bard1, achieved by the transfection of TAC-2 cells with plasmids constitutively expressing ribozymes or antisense RNAs, resulted in marked phenotypic changes, consisting of altered cell shape, increased cell size, high frequency of multinucleated cells, and aberrant cell cycle progression. Furthermore, Bard1-repressed cell clones overcame contact inhibition of cell proliferation when grown in monolayer cultures and lost the capacity to form luminal structures in three-dimensional collagen gels. These results demonstrate that Bard1 repression induces complex changes in mammary epithelial cell properties which are suggestive of a premalignant phenotype.
Promoting Investments in Intangible Organizational Assets through Aligned Incentive Compensation Plans (2006)

In order for large companies to continue to compete and expand in the global business world, it is important that the performance and compensation of strategic business unit managers are aligned with the organization’s overall long-term goals and strategies.
A Vibration-Based Vehicle Classification System using Distributed Optical Sensing Technology (2018)

This paper presents a vibration-based vehicle classification system using distributed optical vibration sensing (DOVS) technology and describes a comprehensive classification method including signal processing and feature extraction. With low maintenance costs, this system can collect vehicle classification data in a larger scale. At first, it utilizes an embedded sensing fiber as a distributed sensor to collect traffic-induced vibration signals, and then extracts several features from the raw signals to estimate axle configurations and identify vehicle categories. At the same time, an empirical mode decomposition (EMD)-based method is applied to reconstruct signals for features extraction, and then several extraction algorithms are proposed to obtain the axle configuration, moving speed, and frequency-domain feature of each vehicle. When all features are extracted, a multi-step classifier is designed to categorize vehicles into different classes. In addition, to evaluate the classification performance of this system, a prototype system was installed on a relief road in Shanghai, China using precast concrete pavement technology. With an overall accuracy of 89%, the test results show a good performance of this classification system.
에큐메니즘에 대한 비판적 해석학적 성찰 (2013)

올해 역사적인 제10차 WCC 부산총회(2013. 10. 30-11. 8)를 앞두고 한국교회는 교에큐메니즘의 본성, 정신 및 활동에 대한 신학적 갈등 및 교회적 분열에 직면해 있다. 필자는 한국교회의 에큐메니칼 운동의 근원적 위기를 교회일치와 선교의 상호관계성에 대한 신학적 대화 및 이해의 결핍으로 보면서, WCC 부산총회의 온전한 축제적 만남을 위하여, 한국교회들 사이의 신학적 반감과 교회적 분열을 치유할 수 있는 대안으로 에큐메니즘에 대한 비판적 해석학적 성찰을 아래와 같이 시도한다. 첫째, 에큐메니즘의 정의, 역사 및 위기를 통해 교회일치운동의 공헌 및 위기의 근원을 알아본다. 둘째, 에큐메니즘의 위기의 대안으로 교회의 다양성, 통일성 및 선교의 상호관계성 그리고 교회일치의 종말 론적 본성 및 단계에 대한 신학적 대화 및 이해를 제시한다. 셋째, 교회 일치운동의 온전한 수행을 위하여, 교회의 일치와 선교에 대한 신학적 대화 및 이해를 통한 합의(수렴)에 이르는 해석학적 과제, 즉 신학의 해석학적 본성, 필연성 및 과정을 알아본다. 넷째, 상호비판적 해석학적 차원들과 교회일치의 종말론적 단계를 연결시켜, 제10차 WCC 부산총회와 관련하여 발생한 한국교회의 신학적 갈등과 교회적 분열을 치유할 수 있는 해결책들을 비판적 해석학적 관점에서 제시해본다. 끝으로 교회일치운동의 종말론적 해석학적 본성 및 단계를 확인하면서, 신학의 갈등을 합의로, 교회의 분열을 일치로 회복하기 위해 에큐메니칼 대화와 선교는 필수적임을 강조하며 글을 맺는다.
Supporting Service Level Agreements on IP Networks (1999)

Abstract: This paper provides an overview of service-level agreements in IP networks. It looks at the typical components of a service-level agreement, and identifies three common approaches that are used to satisfy service level agreements in IP networks. The implications of using the approaches in the context of a network service provider, a hosting service provider, and an enterprise are examined. While most providers currently offer a static insurance approach towards supporting service level agreements, the schemes that can lead to more dynamic approaches are identified. Keywords: SLA, Service Level Agreements, Network Management. 1.
Field-effect transistors as tunable infrared detectors (1996)

We present a theory of tunable infrared response in field-effect transistors. The linear α(ω) and second-order β(ω) polarizability are calculated numerically as functions of frequency of an applied electric field. Transitions between electron subbands in the inversion layer cause resonances in the frequency response, which are tunable with a gate voltage.
A Whole More Than the Sum of Its Synthetic Parts (2008)

Synthetic biology is the realization of systems with desired behavior using biological materials. A recent addition to the field is a bipartite consortium of the bacterium Escherichia coli in which each species harbors complementary gene circuits that actuate only when both are present above a critical density. This bacterial "consensus" system, functional in liquid, solid, and biofilm niches, represents a novel strategy that raises the bar in terms of the specificity and complexity of tasks performed by engineered organisms.