gebhart/patrepeval huggingface dataset:
Cerium Oxide Nanoparticle Reduction of Oxidative Damage in Retina (2012)

Cerium oxide (CeO2) nanoparticles (nanoceria) have attracted significant attention in the area of biomedical applications recently, although they have been widely used in a variety of fields for more than 10 years. In its nanometer (atomic scale) range, nanoceria exhibit unique properties, such as resistance to high temperature degradation, solid electrolytes, regenerative abilities to scavenge reactive oxygen species (ROS), catalytic antioxidant activities, and a defined lattice structure. These features make nanoceria a unique nanomedicine for the treatment of a variety of diseases in which ROS have been demonstrated to be a major causative factor. The use of specially designed nanoceria to treat inherited ocular diseases was first demonstrated by our lab, and they have been shown to be effective and persistent in preventing ROS-induced damage and preserving retinal structure and function without any adverse side effects. In this chapter, we review recent publications of nanoceria characteristics, biological effects, their application in biological fields—including our recent work, evaluation of their toxicity, and perspectives for the future applications.
Dual action of phosphonoformic acid on Na(+)-phosphate cotransport in opossum kidney cells (1992)

Phosphonoformic acid (PFA, foscarnet) was found to exert both an inhibitory and a stimulatory effect on Na(+)-dependent Pi transport in opossum kidney (OK) cells. When added in the uptake media, PFA produced a dose-dependent inhibition of Na(+)-Pi cotransport. PFA had no effect on the Na(+)-dependent transports of methyl-alpha-D-glucopyranoside (AMG) or L-alanine or on amiloride-sensitive Na(+)-H+ antiport. The inhibition of Na(+)-Pi cotransport was competitive [inhibitory constant (Ki) = 6.0 mM], reversible by dilution, and solute specific. When OK cells were incubated with PFA for longer time periods (1-15 h), the Na(+)-Pi uptake measured after removal of PFA was significantly increased, i.e., "upregulated." The extent of Na(+)-Pi cotransport upregulation was dependent on time (greater than or equal to 30 min) and dose of PFA (2-10 mM). The increase in Na(+)-Pi cotransport by upregulation with PFA was due to higher apparent Vmax with no change in apparent Michaelis constant (Km) for Pi and was solute specific: uptakes of AMG or L-proline were not changed. Removal of PFA from culture medium resulted in a fast reversal of upregulation. Upregulation was not inhibited by cycloheximide, actinomycin D, or cordycepin. Solute-specific increase of Na(+)-Pi cotransport was also found when measured in apical membrane vesicles isolated from OK cells. Thus PFA exerts a dual action on the Na(+)-Pi cotransporter of OK cells: 1) acute, competitive inhibition and 2) after prolonged exposure it increases Na(+)-Pi uptake, probably by insertion of Na(+)-Pi cotransporters into apical membrane.
New rosin emulsion sizing agent. (1989)

New type of rosin emulsion, stabilized with a synthetic anionic polymer, recently came into the market. The new rosin emulsion shows better mechanical, chemical (dilution with hard water), and freeze-thaw stability, better re-dispersibility of dried emulsion, less foaming in paper making system, and better sizing efficiency than conventional ones, which are stabilized with anionic low-molecular-weight surfactant.In this article, the performances of this rosin emulsion were introduced and the protectivity of the stabilizers are also discussed.
Psychopharmacological study with K 8409, a 1H-naphtho[2,1-b]pyran 3-dialkylamino substituted derivative. (1979)

A 1H-naphtho[2,1-b]pyran derivative (K 8409) has undergone pharmacological investigation for psychotropic activity. The results show potential antidepressant action quantitatively similar to that of imipramine and amitriptyline, but due rather to MAO inhibition than to imipramine-like activity; interestingly enough, anti-MAO activity was particularly selective for the serotonin-converting enzyme, both centrally and peripherally. The outcome of the other tests suggests that the incidence of untoward effects is likely to be limited.
Demonstration of a nanoparticle-based optical diode (2006)

We present the operation of an optical device that exhibits diodelike properties based on two adjacent layers of quantum dots (QDs) encased in a fiber-optic jacket. The possibility of a multilayered device is also discussed. A significant change in the emission spectrum of CdSe/ZnS core-shell QDs was observed when excited by the input laser and the fluorescence of other CdSe/ZnS core-shell QDs. The output of the diode can be taken to be either the incoming laser wavelength of light similar to a conventional diode, or the output may be considered to be one of the QD fluorescence wavelengths. Current work has applications in biological fluorescence monitors and sensors as well as in telecommunications applications.
Mitigation of fiber nonlinear impairments in polarization division multiplexed OFDM transmission (2010)

Fiber nonlinear effects are found to cause severe signal degradation in long-haul coherent optical OFDM (CO-OFDM) transmission, particularly in dispersion-managed transmission. We present promising techniques to mitigate the fiber nonlinear impairments in both single-channel and wavelength division multiplexed (WDM) transmission. For single-channel transmission, we discuss a joint self-phase modulation (SPM) compensation scheme that is applicable to polarization division multiplexed (PDM) CO-OFDM signals. Experimental demonstration of this joint SPM compensation scheme is also presented. For WDM transmission, we describe an OFDM frame design and a dispersion management scheme that reduce the cross-phase-modulation (XPM) penalty among the WDM channels. The impact of XPM from WDM channels with different signal formats and data rates is briefly discussed. é 2010 Alcatel-Lucent.
Novel AIDS vaccine approach using epithelial stem cells as mucosal antigen-presenting cells (2012)

Background Because HIV transmission occurs predominantly across mucosal surfaces, the ideal vaccine strategy to prevent infection would be to target HIV at mucosal entry sites of transmission. We investigated a novel vaccine approach, which aim is to elicit long-term immunity against HIV infection at the entry site of the virus. This strategy relies on the expression of viral proteins from epithelial stem cells at the basal layer of the epithelium and using a promoter that is specific for terminally differentiated epithelial.
Deployable Booms and Antennas Using Bi-stable Tape-springs (2010)

Utilizing the orthotropic properties of composite materials, tape-spring structural elements can be made that exhibit the unique behavior known as bi-stability. Tape-springs with this behavior display a controlled and deterministic deployment path of simply unrolling once initiated; they do not bloom. Deployable booms and multi-element antennas have been conceptualized based on these tape-springs and are reported on within. Both inventions occupy approximately ¼U of a CubeSat volume (50 x 50 x100 mm) when packaged and self-deploy to lengths of several meters. The boom concept employs four tape-springs arranged so that the boom tips separate linearly (without any rotations). It is intended to be used as a gravity gradient stabilization boom, camera boom or sensor boom. A damper element can be used to control deployment rate. The antenna concept uses multiple elements in a log periodic configuration and is deployed without rate control.
Structures of a pan‐specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody–antigen interactions (2014)

Various important biological pathways are modulated by TGFβ isoforms; as such they are potential targets for therapeutic intervention. Fresolimumab, also known as GC1008, is a pan-TGFβ neutralizing antibody that has been tested clinically for several indications including an ongoing trial for focal segmental glomerulosclerosis. The structure of the antigen-binding fragment of fresolimumab (GC1008 Fab) in complex with TGFβ3 has been reported previously, but the structural capacity of fresolimumab to accommodate tight interactions with TGFβ1 and TGFβ2 was insufficiently understood. We report the crystal structure of the single-chain variable fragment of fresolimumab (GC1008 scFv) in complex with target TGFβ1 to a resolution of 3.00 Å and the crystal structure of GC1008 Fab in complex with TGFβ2 to 2.83 Å. The structures provide further insight into the details of TGFβ recognition by fresolimumab, give a clear indication of the determinants of fresolimumab pan-specificity and provide potential starting points for the development of isoform-specific antibodies using a fresolimumab scaffold.
Method for steering a vessel with towed equipment (2015)

This document presents a new method to automatically control the autopilot of a survey vessel so that the towed equipment follows some predetermined tracks even in case of sea currents.
Data hiding in curves with application to fingerprinting maps (2005)

This paper presents a new data hiding method for curves. The proposed algorithm parameterizes a curve using the B-spline model and adds a spread spectrum sequence to the coordinates of the B-spline control points. In order to achieve robust fingerprint detection, an iterative alignment-minimization algorithm is proposed to perform curve registration and to deal with the nonuniqueness of B-spline control points. Through experiments, we demonstrate the robustness of the proposed data-hiding algorithm against various attacks, such as collusion, cropping, geometric transformations, vector/raster-raster/vector conversions, printing-and-scanning, and some of their combinations. We also show the feasibility of our method for fingerprinting topographic maps as well as writings and drawings.
A stable and practical implementation of least-squares reverse time migration (2014)

ABSTRACT By adapting reverse time migration (RTM) and demigration as the migration and modeling operators to maximize the crosscorrelation between the simulated and the acquired seismic data, we introduced a new practical least-squares RTM (LSRTM) scheme and derived a steepest descent method in seeking the optimal image. Through synthetic and real data experiments, we determined that the proposed LSRTM provided high-quality images with balanced amplitudes, improved focusing, and enhanced resolution. The method was also capable of removing free surface ghosts caused by towed streamer acquisition, filling the structures and reducing crosstalk noise associated with simultaneous shooting.
New Thermoplastic Heat-Activated Adhesives for Polypropylene: A Route to New Composites, Products and Manufacturing Methods (2003)

<div class="htmlview paragraph">Polypropylene is an attractive and relatively low cost polymer which finds numerous applications in the engineering and other market sectors such as textiles, footwear and packaging. It is commonly accepted that it is very difficult to bond this material to itself, or other materials, using adhesives without using expensive surface treatment methods or adhesives which do not lend themselves to fast manufacturing methods because of slow cure times. The aim of the presentation will be to describe a new range of heat-activated adhesives, recently developed in our research laboratories that offer numerous advantages for the rapid manufacture of composite materials.</div>
Block Product Code Design With the Aid of Union Bounds (2005)

Applying soft-input soft-output iterative decoding allows block product codes (BPCs) to exhibit error-correcting capability close to that of convolutional code-based turbo codes. However, finding the best BPC design for a given target code size can be difficult. This paper analyzes BPC performance using weight distribution and union bounds, which leads to a systematic BPC design procedure. The analysis is supported by simulations and examples.
Cluster-Based Cooperative Spectrum Sensing in Cognitive Radio Systems (2007)

In cognitive radio systems, secondary users can be coordinated to perform cooperative spectrum sensing so as to detect the primary user more accurately. However, when the sensing observations are forwarded to a common receiver through fading channels, the sensing performance can be severely degraded. In this paper, we propose a cluster-based cooperative spectrum sensing method to improve the sensing performance. By separating all the secondary users into a few clusters and selecting the most favorable user in each cluster to report to the common receiver, the proposed method can exploit the user selection diversity so that the sensing performance can be enhanced. Furthermore, decision fusion and energy fusion are both studied and the analytical performance results are given. Numerical results show that the sensing performance is improved significantly as opposed to conventional spectrum sensing.
Diphenyloxazaborolidine for Enantioselective Reduction of Ketones (1996)

A systematic investigation of oxazaborolidine structure and enantioselectivity relationships resulted in the identification of diphenyloxazaborolidine as an efficient catalyst for enantioselective reduction of prochiral ketones. The primary requirement for a good oxazaborolidine catalyst to obtain high enantiomeric excess in prochiral ketone reductions was to completely block one face of the oxazaborolidine. Alkyl substitution of nitrogen in erythro oxazaborolidines provided lower enantiomeric excess due to retarded rate of borane coordination and competition from the endo transition state. Relative enantioselectivities were correctly predicted by ab initio calculations, and the calculated structures, energetics, and the existence of key intermediates were demonstrated to be sensitive to the level of theory applied. Ab initio calculations and utility of diphenyloxazaborolidine are described in detail.
Contactless Thermometry of a Textile Web by Microwave Radiometry (1986)

We present a new application of microwave radiometry devoted to the contactless thermometry of a textile web. An interpretation of the radiometric data is proposed. It is also shown in which way this process can be used to determine a thermal profile which exists along the web.
Protecting SIP-Based Networks and Services from Unwanted Communications (2008)

In recent times, SIP-based communication systems have become more and more popular (e.g., in open networks, NGN, IMS, etc.). With continuously dropping cost for the usage of such systems (e.g., VoIP, IM, IPTV), many researchers anticipate the amount of unsolicited communication within the network to reach an alarming high level in the near future. Thus, protection of such systems is needed to counter this threat. We present a holistic protection framework for SIP based infrastructures and describe the most recent enhancements of the system.
Near-diffraction-limited and low-haze electro-optical tunable liquid crystal lens with floating electrodes (2013)

A near-diffraction-limited, low-haze and tunable liquid crystal (LC) lens is presented. Building on an understanding of the key factors that have limited the performance of lenses based on liquid crystals, we show a simple design whose optical quality is similar to a high quality glass lens. It uses 'floating' electrodes to provide a smooth, controllable applied potential profile across the aperture to manage the phase profile.
Total Synthesis of Nominal Diazonamides—Part 1: Convergent Preparation of the Structure Proposed for (−)-Diazonamide A (2001)

Einer genauen Prüfung konnte sie nicht standhalten, die ursprünglich dem antimitotisch wirksamen Naturstoff (−)-Diazonamid A 1 zugeordnete Struktur. Das durch eine konvergente, stereokontrollierte Totalsynthese erhaltene Produkt zeigt andere physikalische und spektroskopische Eigenschaften als eine natürliche Probe. Neuinterpretationen publizierter Daten und neue Erkenntnisse lassen nun den Schluss zu, dass Diazonamid A tatsächlich die Struktur 2 mit einer Aminal-Einheit und einer (S)-α-Hydroxyisovaleriansäure-Seitenkette hat. Erfreulicherweise erwies sich ein Kongener von 2 mit einer C11-Acetal-Einheit als biologisch ähnlich aktiv wie der Naturstoff.
Three-Dimensional Image Information Media. A 3-D Shape Measurement Method for Objects with Uneven Reflective Surfaces. (1998)

A method for measuring 3-D objects with surfaces composed of various reflective regions is developed in which the 3-D coordinates of the object sections are obtained by triangulation with the light-section method by using a slit-light source and a TV camera. A slit-light source in which the lighting intensity is controllable and a TV camera with an expanded dynamic range are employed to reduce the influence of uneven reflective surfaces. The TV camera expands its dynamic range by combining multiple images captured at different shutter speeds. A trial 3-D shape measurement system is produced using this method, and its effectiveness is confirmed by experiments.
Miniaturization of Quad Port Helical Antenna for Wireless 5G Massive MIMO Application (2018)

A novel technique for the miniaturization of a quadrifilar helical antenna (QHA) with four independent ports, including for use in multiple-input multiple-output (MIMO) communication systems and other wireless communication systems. With the addition of one or more conductive components, a QHA may be achieved that has a more compact size, improved radiation patterns, sufficiently wide impedance bandwidth. Design is applied at 2.1–2.7 GHz.
A stabilization technique for phase-locked frequency synthesizers (2003)

A stabilization technique is presented that relaxes the tradeoff between the settling speed and the magnitude of output sidebands in phase-locked frequency synthesizers. The method introduces a zero in the open-loop transfer function through the use of a discrete-time delay cell, obviating the need for resistors in the loop filter. A 2.4-GHz CMOS frequency synthesizer employing the technique settles in approximately 60 μs with 1-MHz channel spacing while exhibiting a sideband magnitude of -58.7 dBc. Designed for Bluetooth applications and fabricated in a 0.25-μm digital CMOS technology, the synthesizer achieves a phase noise of -112 dBc/Hz at 1-MHz offset and consumes 20 mW from a 2.5-V supply.
Design Criteria for Ultrathin Single‐Layer Flash Memristors from an Organic Polyradical (2016)

The quest for memory devices with “flash” properties, suitable to retain information without any external power source but capable of satisfying the thinness requirements of next‐generation electronics, demands the development of device architectures with a homogeneous layer of active material that can be made as thin as possible. Here, an ultrathin memory device is presented in which the active layer is formed by a 10‐nm homogeneous film of poly‐[ 1,5 ‐diisopropyl‐ 3 ‐( cis ‐ 5 ‐norbornene‐exo‐ 2,3 ‐dicarboxiimide) 6 ‐oxoverdazyl] (P6OV) a polyradical with three tunable charge states per radical monomer: positive, neutral, and negative. To the best of our knowledge, these are the thinnest organic flash memristors obtained to date. Careful engineering of the anode and cathode work functions, specifically aligning them with the negative and positive energy levels of the polyradical, is vital to maximize the on/off current ratio and ensure flash operation. Conversely, devices in which the cathode work function aligns with the neutral energy level of P6OV are writable only once. The bistability of this memristors is assigned to two distinct transport regimes in organic polyradicals: extended states and Poole–Frenkel.
Blood-Feeding Strategy of Haematobia irritans (Diptera: Muscidae) (1998)

The economic impact on livestock production by Haematobia irritans (L.) is estimated to approach $1 billion per year in North America. However, there is little information regarding the blood-feeding strategy used by these insects. Information presented here shows that horn fly saliva interferes with the normal coagulation response as measured by the recalcification time assay. The relative anticoagulant activity on a per-gland basis was more than or equal to that reported for Simulium vittatum Zetterstedt, a common hematophagous black fly that also feeds on cattle. However, unlike S. vittatum, H. irritans salivary factors do not inhibit platelet aggregation using apyrase and have no detectable vasodilative activity. In this regard, the horn fly is strikingly different from blood-feeding species in the lower Diptera and shows a much more limited repertoire of antihemostatic factors.
Optical arrays and pattern recognition in the design of an artificial nose (1996)

Array sensors capable of multi-vapor discrimination have been developed that employ fiber optic bundles, CCD cameras, and artificial neural network processing. Sensors have been constructed both through spatial deposition of dye-containing photopolymers on an imaging fiber, and via individual polymer/dye coatings placed on individual single-core fibers and then bundled. Cross-reactive sensing regions are created by using a variety of polymers. The resulting array is then challenged with a variety of analytes. Vapor pulses give rise to temporal response patterns which are used to train a neural network. The final sensor array system can identify subsequent challenges with the analyte over extended periods of time with up to 100% accuracy. The sensor can also characterize analytes on the basis of functional groups and molecular weight, and is capable of identifying components of mixtures.
Synthesis of Novel Taxoids (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Novel TaxoidsK. C. Nicolaou, Christopher F. Claiborne, Philippe G. Nantermet, Elias A. Couladouros, and Erik J. SorensenCite this: J. Am. Chem. Soc. 1994, 116, 4, 1591–1592Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ja00083a063https://doi.org/10.1021/ja00083a063research-articleACS PublicationsRequest reuse permissionsArticle Views2341Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts