gebhart/patrepeval huggingface dataset:
Position calibration of audio sensors and actuators in a distributed computing platform (2003)

In this paper, we present a novel approach to automatically determine the positions of sensors and actuators in an ad-hoc distributed network of general purpose computing platforms. The formulation and solution accounts for the limited precision in temporal synchronization among multiple platforms. The theoretical performance limit for the sensor positions is derived via the Cramer-Rao bound. We analyze the sensitivity of localization accuracy with respect to the number of sensors and actuators as well as their geometry. Extensive Monte Carlo simulation results are reported together with a discussion of the real-time system. In a test platform consisting of 4 speakers and 4 microphones, the sensors' and actuators' three dimensional locations could be estimated with an average bias of 0.08 cm and average standard deviation of 3.8 cm.
Combined linear-logarithmic CMOS image sensor (2004)

A 352/spl times/288 pixel array achieves >120 dB dynamic range through merging sequential linear and logarithmic images. Calibration is used to match offset and gain. A 7-transistor pixel is built in a 0.18 /spl mu/m 1P4M CMOS process.
Reversible Conduction Block in Peripheral Nerve Using Electrical Waveforms (2017)

Electrical nerve block is an emerging technique that has many significant advantages over other methods of nerve block. This field is still in its infancy, but a significant expansion in the clinical application of this technique is expected in the coming years.
Engineering optical space with metamaterials (2008)

Metamaterials are expected to open a gateway to unprecedented electromagnetic properties and functionality unattainable from naturally occurring materials, thus enabling a family of new meta-devices. We review this new emerging field and significant progress in developing metamaterials for the optical part of the spectrum. Specifically, we describe recently demonstrated artificial magnetism across the whole visible, negative-index in the optical range, and promising approaches along with challenges in realizing optical cloaking. The new paradigm of engineering space for light with transformation optics will be also discussed.
Shape similarity based on contour decomposition and correspondence (2006)

A shape similarity measure based on contour decomposition and part correspondence is introduced. Shapes are approximated by polygons with split-and-merge technique, and a set of perceptual and easily reconfigurable attributes are designed to model the polygonal curves. To compute our similarity measure, the correspondence of polygonal curves is established by DP technique. Then, the similarity between them is computed and aggregated. To verify the effectiveness of our algorithm, we apply it to shape retrieval in two different datasets, one of marine species shapes and another of mechanical shapes, and compare it with some traditional approaches
Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension (2018)

Purpose To develop and validate a computational model for estimating hepatic venous pressure gradient (HVPG) based on CT angiographic images, termed virtual HVPG, to enable the noninvasive diagnosis of portal hypertension in patients with cirrhosis. Materials and Methods In this prospective multicenter diagnostic trial (ClinicalTrials.gov identifier: NCT02842697), 102 consecutive eligible participants (mean age, 47 years [range, 21-75 years]; 68 men with a mean age of 44 years [range, 21-73 years] and 34 women with a mean age of 52 years [range, 24-75 years]) were recruited from three high-volume liver centers between August 2016 and April 2017. All participants with cirrhosis of various causes underwent transjugular HVPG measurement, Doppler US, and CT angiography. Virtual HVPG was developed with a three-dimensional reconstructed model and computational fluid dynamics. Results In the training cohort (n = 29), the area under the receiver operating characteristic curve (AUC) of virtual HVPG in the prediction of clinically significant portal hypertension (CSPH) was 0.83 (95% confidence interval [CI]: 0.58, 1.00). The diagnostic performance was prospectively confirmed in the validation cohort (n = 73), with an AUC of 0.89 (95% CI: 0.81, 0.96). Inter- and intraobserver agreement was 0.88 and 0.96, respectively, suggesting the good reproducibility of virtual HVPG measurements. There was good correlation between virtual HVPG and invasive HVPG (R = 0.61, P < .001), with a satisfactory performance to rule out (7.3 mm Hg) and rule in (13.0 mm Hg) CSPH. Conclusion The accuracy of a computational model of virtual hepatic venous pressure gradient (HVPG) shows significant correlation with invasive HVPG. The virtual HVPG also showed a good performance in the noninvasive diagnosis of clinically significant portal hypertension in cirrhosis. © RSNA, 2018 Online supplemental material is available for this article. See also the editorial by Malayeri in this issue.
Distributed behavior collaboration for self-reconfigurable robots (2004)

This paper describes a distributed and decentralized approach for modules in a self-reconfigurable robot to select appropriate behaviors based on four factors: the current global task, the local topological location in the current configuration, the local state/sensor information, and the received messages from their neighbors. This approach does not assume any unique global identifiers for the modules, and is robust for reconfigurations of modules. The approach is enabled by the extended neighbor topology built upon a previous local topology representation and a hormone-inspired communication and control protocols. Experimental results on the CONRO robot have shown some unique features of this approach for the control of self-reconfigurable robots in general.
Three-dimensional visualization of the functional fascicular groups of a long-segment peripheral nerve (2018)

The technique is fast with satisfactory visual reconstruction.
Electrochemical DNA Sensors (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Antenna-Diversity Techniques in Cars for FM-Radio, TV and Cellular Phone (1999)

Car producers prefer multi antenna scanning diversity systems to improve FM and TV reception quality. These systems are highly efficient and cost effective to reduce distortions going along with multipath propagation. A criterion for the diversity effectiveness of a multi-antenna arrangement on a car is derived. This number of equivalent decorrelated antennas being effective is evaluated by turntable antenna measurements as a basis for computer simulated virtual drives in a Rayleigh wave propagation scenario. The comparison of different antenna arrangements shows that even compact antenna systems integrated on one single car window provide high diversity effectiveness. Even mobile phone reception quality for GSM can be increased.
[1-(.beta.-Mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid),4-valine, 8-D-arginine]vasopressin, a potent and selective inhibitor of the vasopressor response to arginine-vasopressin (1978)

As part of a program in which we are attempting the design and synthesis of an antagonist of the antidiuretic response to arginine-vasopressin (AVP) [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),4-valine,8-D-arginine]vasopressin [d(CH2)5VDAVP] was synthesized and assayed for antidiuretic, vasopressor, and oxytocic activities. The required protected intermediate was synthesized by a combination of solid-phase synthesis and an [8 + 1] coupling in solution. d(CH2)5VDAVP has an antidiuretic potency of 0.10 +/- 0.02 unit/mg, less than 1/10000 that of its parent [deamino,4-valine,8-D-arginine]vasopressin (dVDAVP). d(CH2)5VDAVP is a specific antagonist of the vasopressor responses to AVP. It has an antivasopressor pA2 value of 7.68 +/- 0.05 when tested against AVP. It is also an antagonist of the in vitro oxytocic response to oxytocin (pA2 value = 6.62 +/- 0.07). With its negligible antidiuretic activity, absence of oxytocic activity, and its potent and specific ability to antagonize the vasopressor effects of AVP, d(CH2)5VDAVP is one of the most potent and selective vasopressor antagonists reported to date. It should thus be a useful tool with which to probe the possible role(s) that AVP may play in cardiovascular regulation under normal and pathological conditions.
Stalking influenza by vaccination with pre-fusion headless HA mini-stem (2016)

Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid production and deployment. The hemagglutinin (HA) stem is a promising target for universal influenza vaccine as stem-specific antibodies have the potential to be broadly cross-reactive towards different HA subtypes. Here, we report the design of a bacterially expressed polypeptide that mimics a H5 HA stem by protein minimization to focus the antibody response towards the HA stem. The HA mini-stem folds as a trimer mimicking the HA prefusion conformation. It is resistant to thermal/chemical stress, and it binds to conformation-specific, HA stem-directed broadly neutralizing antibodies with high affinity. Mice vaccinated with the group 1 HA mini-stems are protected from morbidity and mortality against lethal challenge by both group 1 (H5 and H1) and group 2 (H3) influenza viruses, the first report of cross-group protection. Passive transfer of immune serum demonstrates the protection is mediated by stem-specific antibodies. Furthermore, antibodies induced by these HA stems have broad HA reactivity, yet they do not have antibody-dependent enhancement activity.
Experimental Study of a Two-Phase Heat Transport Device Driven by Electrohydrodynamic Conduction Pumping (2008)

Heat pipes are well-known as simple and effective heat transport devices, utilizing two-phase flow and the capillary phenomenon to remove heat. However, the generation of capillary pressure requires a wicking structure and the overall heat transport capacity of the heat pipe is generally limited by the amount of capillary pressure generation that the wicking structure can achieve. Therefore, to increase the heat transport capacity, the capillary phenomenon must be either augmented or replaced by some other pumping technique. Electro-hydrodynamic (EHD) conduction pumping has been demonstrated as an effective method for pumping liquid films by using DC electric fields and a dielectric working fluid. Beyond increased pumping capacity, EHD conduction pumping offers other advantages over capillary pumping, such as active control of the pumping capacity via the intensity of the applied electric field. This experimental study demonstrates the prospects of a macro-scale two-phase heat transport device that is driven by EHD conduction pumping. Various liquid film thicknesses are considered. In each case, the performance of the EHD-driven heat transport device at various electric field intensities is compared to the capabilities of the same device under gravity alone. The effect of tilt on the device is also considered.
Criteria for developing castable, creep-resistant aluminum-based alloys – A review (2006)

Abstract We describe four criteria for the selection of alloying elements capable of producing castable, precipitation-strengthened Al alloys with high-temperature stability and strength: these alloying elements must (i) be capable of forming a suitable strengthening phase, (ii) show low solid solubility in Al, (iii) low diffusivity in Al, and (iv) retain the ability for the alloy to be conventionally solidified.With regard to criterion (i), we consider those systems forming Al 3 M trialuminide compounds with a cubic L1 2 crystal structure, which are chemically and structurally analogous to Ni 3 Al in the Ni-based superalloys. Eight elements, clustered in the same region of the periodic table, fulfill criterion (i): the first Group 3 transition metal (Sc), the three Group 4 transition metals (Ti, Zr, Hf) and the four latest lanthanide elements (Er, Tm, Yb, Lu). Based on a review of the existing literature, these elements are assessed in terms of criteria (ii) and (iii), which satisfy the need for a dispersion in Al with slow coarsening kinetics, and criterion (iv), which is discussed based on the binary phase diagrams.
Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors (2012)

Cellular infection by HIV-1 is initiated with a binding event between the viral envelope glycoprotein gp120 and the cellular receptor protein CD4. The CD4-gp120 interface is dominated by two hotspots: a hydrophobic gp120 cavity capped by Phe43(CD4) and an electrostatic interaction between residues Arg59(CD4) and Asp368(gp120). The CD4 mimetic small-molecule NBD-556 (1) binds within the gp120 cavity; however, 1 and related congeners demonstrate limited viral neutralization breadth. Herein, we report the design, synthesis, characterization, and X-ray structures of gp120 in complex with small molecules that simultaneously engage both binding hotspots. The compounds specifically inhibit viral infection of 42 tier 2 clades B and C viruses and are shown to be antagonists of entry into CD4-negative cells. Dual hotspot design thus provides both a means to enhance neutralization potency of HIV-1 entry inhibitors and a novel structural paradigm for inhibiting the CD4-gp120 protein-protein interaction.
Synthesis of Acyclonucleoside Phosphonates for Evaluation as Antiviral Agents (1989)

Isosteric phosphonate analogs of acyclovir and ganciclovir have been prepared and found to have significant activity against human and murine cytomegalovirus in vitro. The mono ethyl esters also are active, possibly serving as prodrugs for the diphosphonic acids. Higher homologs of the isosteris resulted in significant loss of antiviral activity. The phosphonates appear to have low toxicity and some of them are promising candidates for clinical evaluation.
Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer’s Disease (2016)

MicroRNAs have emerged as key factors in development, neurogenesis and synaptic functions in the central nervous system. In the present study, we investigated a pathophysiological significance of microRNA-188-5p (miR-188-5p) in Alzheimer's disease (AD). We found that oligomeric Aβ<sub>1-42</sub> treatment diminished miR-188-5p expression in primary hippocampal neuron cultures and that miR-188-5p rescued the Aβ<sub>1-42</sub>-mediated synapse elimination and synaptic dysfunctions. Moreover, the impairments in cognitive function and synaptic transmission observed in 7-month-old five familial AD (5XFAD) transgenic mice, were ameliorated via viral-mediated expression of miR-188-5p. miR-188-5p expression was down-regulated in the brain tissues from AD patients and 5XFAD mice. The addition of miR-188-5p rescued the reduction in dendritic spine density in the primary hippocampal neurons treated with oligomeric Aβ<sub>1-42</sub> and cultured from 5XFAD mice. The reduction in the frequency of mEPSCs was also restored by addition of miR-188-5p. The impairments in basal fEPSPs and cognition observed in 7-month-old 5XFAD mice were ameliorated via the viral-mediated expression of miR-188-5p in the hippocampus. Furthermore, we found that miR-188 expression is CREB-dependent. Taken together, our results suggest that dysregulation of miR-188-5p expression contributes to the pathogenesis of AD by inducing synaptic dysfunction and cognitive deficits associated with Aβ-mediated pathophysiology in the disease.
A Multisensor Algorithm Predicts Heart Failure Events in Patients With Implanted Devices (2017)

The HeartLogic multisensor index and alert algorithm provides a sensitive and timely predictor of impending HF decompensation. (Evaluation of Multisensor Data in Heart Failure Patients With Implanted Devices [MultiSENSE]; NCT01128166).
Integrated Nanophotonic Excitation and Detection of Fluorescent Microparticles (2017)

Biological microentities, such as cells and bacteria, are often detected and identified by bulky optical setups such as fluorescent microscopes and flow cytometers. Integrated photonics provides the prospect of dramatically miniaturizing these setups, enabling highly parallelized on-chip detection. In this work we designed, fabricated, and characterized a SiN photonic circuit for fluorescence detection of microentities. A tailored diffraction grating excites fluorescent particles, whose emitted light is collected in a single-mode waveguide by a second neighboring diffraction grating. Both fluorescent polystyrene microparticles and labeled peripheral blood mononuclear cells were detected in a microfluidic channel integrated on top of the waveguide circuit. We quantified both numerically and experimentally the efficiency of this grating system and obtained a good agreement. The presented on-chip fluorescent detection structure and the obtained results will strongly contribute to the development of on-chip cytometry and spectroscopy applications.
Growth inhibitory effect of anti PAR antibodies on PAR-overexpressing tumor cells (2005)

2559 Background: PAR (Prostate Androgen Regulated) is a gene expressed in all normal tissues and is overexpressed in most tumors studied compared to their normal counterparts. The gene is located on chromosome 1 in Epidermal Differentiation Complex. It encodes a 146 aminoacid (aa) transmembrane protein. PAR gene behaves like a protooncogene as revealed by transfection of gene encoding sequence in sense and antisense orientation in NIH3T3 and DU145 cells, respectively. The PAR cellular function is not fully understood but preliminary data suggest that the gene is involved in cell cycle. Methods: A polyclonal antibody (Ab) was raised against a 20 aa peptide (P1) selected from the amino terminal region of deduced PAR sequence. The antibody was affinity purified. The effect of anti PAR antibody on the proliferation of MCF7 breast cancer cell line and DU145 androgen resistant prostate cancer cell line was studied in vitro by cell counts and MTT assay, and in vivo, on the growth of DU145 tumors in SCID mice, treated intraperitoneal twice a week with 50ug Ab, for 17 days. Apoptosis was assessed by flow cytometry using Annexin V-FITC. BCL2, BAX and caspase 3 expression levels were determined by Western blots. Results: Anti PAR Ab is a highly specific antibody which reacted only with the peptide P1, the PAR recombinant protein prepared in E coli, and with lysates from various cell lines. The Ab activity was completely blocked by treatment with the peptide P1. Anti PAR Ab inhibited the proliferation of DU145 and MCF7 tumor cells in vitro in a dose and time dependent manner. At concentration of 9ug Ab/ml only about 10% of the cells were still alive after 5 days, in comparison with controls treated with IgG from normal rabbits. The Ab did not have any effect on MCF10F normal breast cells treated in a similar way. The anti PAR Ab also inhibited significantly the growth of DU145 tumor grafted in CB17 SCID mice. The mechanism of this inhibition involves apoptosis associated with Bcl 2 down regulation and caspase 3 over expression. Conclusions: the data presented here suggest that the anti PAR Ab maybe a potential treatment for breast and prostate cancers. No significant financial relationships to disclose.
Preparation of Bi-Sr-Ca-Cu-O superconductors by the floating-zone melting method (1990)

The authors succeeded in obtaining highly oriented crystalline samples of 2212 Bi-Sr-Ca-Ca-O superconductors by the floating-zone melting method. The critical current densities Jc were largely dependent on the degree of crystalline alignment obtained from a ratio of X-ray diffraction line intensities. For a highly oriented crystal, the authors obtained a value for Jc of 14800 A cm-2 at 77.3 K in the absence of a magnetic field.
Cissampelos pareira Linn: Natural Source of Potent Antiviral Activity against All Four Dengue Virus Serotypes (2015)

Our findings above, taken in the context of the human safety of Cipa, based on its use in Indian traditional medicine, warrant further work to explore Cipa as a source for the development of an inexpensive herbal formulation for dengue therapy. This may be of practical relevance to a dengue-endemic resource-poor country such as India.
Catalytic Performance of NiMoS Supported on (Zr)SBA-15 for Hydrodesulfurization of Diesel: Insight into a One-Step Calcination and Reduction Strategy during Sulfidation (2019)

We report, herein, the catalytic efficiency and activity of a facilely synthesized sulfided NiMo hydrodesulfurization (HDS) catalyst supported on (Zr)-SBA-15 by one-step calcination and reduction heat treatment prior to sulfidation. Zr-SBA-15-Mo is prepared by a direct synthesis approach, followed by the confinement of Ni into the as-synthesized Zr-SBA-15-Mo without calcination, to generate more dispersion and active sites of metal oxides for an efficient sulfidation process. The HDS performance of these catalysts was evaluated and compared to that of the catalysts prepared by the sequential calcination and reduction approach prior to sulfidation for HDS of dibenzothiophene (DBT) and dimethyldibenzothiophene (DMDBT) in commercial diesel at 350 °C in batch reactor mode. Structural and morphological properties related to catalytic activity have been obtained by means of spectroscopy (X-ray diffraction (XRD), Raman, pyridine-Fourier transform infrared (FTIR), temperature-programmed desorption (TPD), microscopy (scanning electron microscopy)), and N2 physisorption. The characterization and investigations from XRD, Raman, pyridine-FTIR, and TPD revealed that avoiding multiple heat treatment in designing HDS catalysts provides more coordinative unsaturated active sites necessary for better catalyst performance and stability. In addition, the textural properties (specific surface area, pore size, and volume) that allow easy diffusion of reactant molecules are better preserved. The activity of the sulfided NiMo catalysts prepared by one-step heat treatment is 9–16% higher for DBT and 11–13% higher for DMDBT at 1 h reaction time compared to that of the catalysts prepared by sequential calcination and reduction before sulfidation. The catalysts prepared by this heat treatment approach have desulfurization efficiencies of 99 and 84% for DBT and DMDBT, respectively.
Evaluation of a specific diagnostic marker for rheumatoid arthritis based on cyclic citrullinated peptide (2015)

A specific peptide marker for diagnosing rheumatoid arthritis (RA) was found based on cyclic citrullinated peptide (CCP) using the following three steps: (1) analysis of the binding epitope of autoimmune antibodies using ϵ-aminocaproic acid-modified peptides; (2) RA diagnosis using sequence-modified peptides; and (3) evaluation of the peptides' diagnostic performance for RA diagnosis. Ninety-five serum samples were analyzed by ELISA and compared using MedCalc (version 15.2.1). Microplate binding ϵ-aminocaproic acid was added to the N- or C-terminal of the CCP sequence. The N-terminal anchoring peptide assay showed 15% higher specificity compared with the C-terminal anchoring peptide assay. Based on this result, the hydrophilic C-terminal sequence of CCP was substituted with a hydrophobic amino acid. Among the sequence-modified peptides, CCP11A (in which alanine was substituted for the 11th amino acid of CCP) assay showed the highest sensitivity (87%) and specificity (100%) for RA diagnosis. Thus, CCP11A was selected as a possible specific marker peptide for RA diagnosis and further analyzed. The results of this analysis indicated that CCP11A showed better specificity than the CCP assay in both healthy individuals (11% better) and OA cohort (20% better). From these results, CCP11A was evaluated as a specific marker for diagnosing RA with higher diagnostic performance.