gebhart/patrepeval huggingface dataset:
BoxNet: A Deep Learning Method for 2D Bounding Box Estimation from Bird's-Eye View Point Cloud (2019)

We present a learning-based method to estimate the object bounding box from its 2D bird's-eye view (BEV) LiDAR points. Our method, entitled BoxNet, exploits a simple deep neural network that can efficiently handle unordered points. The method takes as input the 2D coordinates of all the points and the output is a vector consisting of both the box pose (position and orientation in LiDAR coordinate system) and its size (width and length). In order to deal with the angle discontinuity problem, we propose to estimate the double-angle sinusoidal values rather than the angle itself. We also predict the center relative to the point cloud mean to boost the performance of estimating the location of the box. The proposed method does not rely on the ordering of points as in many existing approaches, and can accurately predict the actual size of the bounding box based on the prior information that is obtained from the training data. BoxNet is validated using the KITTI 3D object dataset, with significant improvement compared with the state-of-the-art non-learning based methods
The kinetic mandala (1999)

We describe the use of artificial life (genetic) algorithms to generate auditory behaviors within 3D graphical environments. Small, high-quality soundfiles are algorithmically recombined and their behavior altered to create rich, non-looping sound environments. These environments consist of sound effects as well as musical tones; for example, the sound of a single water drop or a single ocean wave can be replicated and regenerated according to algorithmic rules to create a long-running nonlooping sound effect. Sonic parameters such as pitch, start time, intensity, and apparent spatial location are given initial values which are then changed in realtime as the Java-based genetic algorithms generate new values. This approach is particularly useful in Web-based 3D environments like VRML or Java3D, as it can dramatically reduce the necessity for downloading large soundfiles. It can also be used in real-world systems to produce long-running, interactive, non-looping sound environments. This work can be thought of as a generalizable content-based form of audio compression. Applications lie in awareness systems, entertainment systems, real/virtual interplay, and especially applications in long-term auditory monitoring and display. The test environment we built to illustrate our system is the Kinetic Mandala, an abstract VRML 2.0 world with six rooms, each containing audio artificial life systems.
Synthesis of a Monophosphoryl Derivative of <i>Escherichia coli</i> Lipid A and Its Efficient Coupling to a Tumor‐Associated Carbohydrate Antigen (2009)

Monophosphoryl lipid A is a safe and potent immunostimulant and vaccine adjuvant, which is potentially useful for the development of effective carbohydrate-based conjugate vaccines. This paper presents a convergent and efficient synthesis of a monophosphoryl derivative of E. coli lipid A that has an alkyne functionality at the reducing end, which is suitable for coupling with various molecules. The coupling of this derivative to an N-modified analogue of tumor-associated antigen GM3 through click chemistry is also presented.
Chip-scale high-performance digital Fourier Transform (dFT) spectrometers (2019)

On-chip spectrometers have recently emerged as a promising alternative to conventional benchtop instruments with apparent Size, Weight, and Power (SWaP) advantages for applications including spectroscopic sensing, optical network performance monitoring, RF spectrum analysis, optical coherence tomography, and hyperspectral imaging. Existing onchip spectrometer designs, however, are limited in spectral channel count and signal-to-noise ratio (SNR). Here we demonstrate a transformative on-chip digital Fourier transform (dFT) spectrometer that can acquire high-resolution spectra via time-domain modulation of a reconfigurable Mach-Zehnder interferometer. The device, fabricated and packaged using industry-standard silicon photonics technology, claims the multiplex advantage to dramatically boost SNR and unprecedented scalability capable of addressing exponentially increasing numbers of spectral channels. We further explored and implemented machine learning regularization techniques to spectrum reconstruction. Using an ‘elastic-D1’ regularized regression method that we developed, we achieved significant noise suppression for both broad (> 600 GHz) and narrow (< 25 GHz) spectral features, as well as spectral resolution enhancement beyond the classical Rayleigh criterion. The dFT architecture and spectrum reconstruction techniques demonstrated in this work will drive future work in on-chip optical spectroscopy and enable practical realizations of high-performance chip-scale spectrometers with large (> 1,000) spectral channel counts.
Data-based node penalties in a path-finding algorithm in an automated material handling system (2003)

Increasing factory throughput is a critical issue in the semiconductor industry, and a quick transition of material to the next location in the automation system plays a significant role in increasing throughput. A dynamic pathfinding algorithm for a vehicle-based automated material handling system (AMHS) is discussed in this paper. The dynamic pathfinding algorithm uses distance between nodes, node penalties, and the number of vehicles queued to calculate the total cost of a path. This paper introduces the use of historical data from the AMHS and discusses how to effectively utilize such data in critical situations to improve overall AMHS performance.
Construction and operation pressurized internally circulating fluidized bed boiler (PICFB) pilot plant (1997)

In the atmospheric pressure coal combustion area, Ebara`s Internally Circulating Fluidized-bed Boiler (ICFB) had already been proven to possess superior performance features. A major feature of the ICFB is that functions of a main combustion chamber are separated from the functions of a heat recovery chamber by a partition inside of the combustor. This led to low NO{sub x} and minimum erosion of immersed tubes. This ICFB can be successfully applied to the pressurized type (PICFB). In PICFB, the facilities for the bed material are very simple and the heating surface is never exposed to the combustion gas. Thus the flue gas temperature is maintained at a constant value; then emissions such as NOx, SOx, CO are kept at the lowest level; and stable efficiency of gas turbine is achieved in spite of load variation. A 4MWth pilot plant design and construction project has been initiated due to be commissioned for demonstration operation in October, 1996.
Super-Agrobacterium ver. 4: Improving the Transformation Frequencies and Genetic Engineering Possibilities for Crop Plants (2019)

<i>Agrobacterium tumefaciens</i> has been utilized for both transient and stable transformations of plants. These transformation methods have been used in fields such as breeding GM crops, protein production in plant cells, and the functional analysis of genes. However, some plants have significantly lower transient gene transfer and stable transformation rates, creating a technical barrier that needs to be resolved. In this study, Super-<i>Agrobacterium</i> was updated to ver. 4 by introducing both the ACC deaminase (<i>acdS</i>) and GABA transaminase (<i>gabT</i>) genes, whose resultant enzymes degrade ACC, the ethylene precursor, and GABA, respectively. <i>A. tumefaciens</i> strain GV2260, which is similar to other major strains (EHA105, GV3101, LBA4404, and MP90), was used in this study. The abilities of the Super-<i>Agrobacterium</i> ver. 4 were evaluated in <i>Erianthus ravennae</i>, <i>Solanum lycopersicum</i> "Micro-Tom," <i>Nicotiana benthamiana</i>, and <i>S. torvum</i>. Super-<i>Agrobacterium</i> ver. 4 showed the highest T-DNA transfer (transient transformation) frequencies in <i>E. ravennae</i> and <i>S. lycopersicum</i>, but not in <i>N. benthamiana</i> and <i>S. torvum</i>. In tomato, Super-<i>Agrobacterium</i> ver. 4 increased the stable transformation rate by 3.6-fold compared to the original GV2260 strain. Super-<i>Agrobacterium</i> ver. 4 enables reduction of the amount of time and labor required for transformations by approximately 72%, and is therefore a more effective and powerful tool for plant genetic engineering and functional analysis, than the previously developed strains. As our system has a plasmid containing the <i>acdS</i> and <i>gabT</i> genes, it could be used in combination with other major strains such as EHA105, EHA101, LBA4404, MP90, and AGL1. Super-<i>Agrobacterium</i> ver. 4, could thus possibly be a breakthrough application for improving basic plant science research methods.
Understanding bichromatic emission from scattering gain media (1996)

Intense optical pumping of solutions of high-gain laser dyes and TiO(2) nanoscatterers in methanol is found to result in narrow-linewidth bichromatic emission. Experimental studies of the long-wavelength emission peak show that weak pumping of the scattering gain medium by the primary lasing emission results in a random system that lases at longer wavelengths. Measurements with other dyes show that the bichromatic emission effect is very general.
High performance liquid chromatography (HPLC) of natural products. IV. The use of HPLC in biosynthetic studies of cephalosporin C in the cell-free system. (1981)

A new cepham metabolite has been isolated from the filtered broth of Cephalosporium acremonium by high performance liquid chromatography (HPLC) and identified as 7 beta-(5-D-amino-adipamido)-3 beta-hydroxy-3 alpha-methyl-cepham-4 alpha-carboxylic acid (I). Pure penicillin N was prepared using HPLC in the analytical mode. When I was added in place of penicillin N as substrate for the cell-free biosynthetic of cephalosporin, no formation of deacetoxycephalosporin C (II) was observed. A synthetic cepham derivative, 7 beta-(5-D-aminoadipamido)-3-exomethylene-cepham-4 alpha-carboxylic acid (III) was also tested in the cell-free system as a possible intermediate. The compound III was shown to be an inhibitor of the ring expansion enzyme that converts penicillin N to deacetoxycephalosporin C.
Evaluating Chemical Mitigation of Porcine Epidemic Diarrhea Virus (PEDV) in Swine Feed and Ingredients (2015)

Porcine Epidemic Diarrhea Virus (PEDV) is primarily transmitted by fecal-oral contamination. Research has confirmed swine feed or ingredients as potential vectors of transmission, so strategies are needed to mitigate PEDV in feed. The objective of this experiment was to evaluate the effectiveness of various chemical additives to prevent or mitigate post-processing PEDV contamination in swine feed and ingredients. Treatments were arranged in a 7 × 4 factorial with seven chemical treatments and four feed matrices. The chemical treatments included: negative control with no chemical addition, 0.3% commercial formaldehyde product, 1% sodium bisulfate, 1% sodium chlorate, 3% custom organic acid blend (OA), 2% custom essential oil blend (EO), and 2% custom medium chain fatty acid blend (MCFA). The four matrices included a complete swine diet, blood meal, meat and bone meal, and spray-dried animal plasma. Matrices were first chemically treated, then inoculated with PEDV, stored at room temperature, and analyzed by RT-PCR on d 0, 1, 3, 7, 14, 21, and 42 post inoculation. Formaldehyde, MCFA, EO, and OA addition each decreased RNA concentration of PEDV compared to the control (P < 0.05), with formaldehyde being the most effective on d 0. Feed matrix appears important in PEDV retention, as RNA concentrations were lower in the swine diet and blood meal than meat and bone meal or spray-dried animal plasma on d 0 (P < 0.05). Additionally, PEDV stability over time was influenced by matrix as RNA concentrations were greater by d 42 for spray-dried animal plasma and meat and bone meal than the complete swine diet and blood meal. In summary, time, formaldehyde, MCFA, EO, and OA all enhance the RNA degradation of PEDV in swine feed and ingredients as measured by RT-PCR, but their effectiveness varies within matrix. Notably, the MCFA was equally as successful at mitigating PEDV as a commercially-available formaldehyde product.
Lamb-Wave Embedded NDE with Piezoelectric Wafer Active Sensors for Structural Health Monitoring of Thin-Wall Structures (2004)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Victor Giurgiutiu; Lamb‐Wave Embedded NDE with Piezoelectric Wafer Active Sensors for Structural Health Monitoring of Thin‐Wall Structures. AIP Conf. Proc. 26 February 2004; 700 (1): 1452–1459. https://doi.org/10.1063/1.1711786 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Automated measurement of quality of mucosa inspection for colonoscopy (2010)

Colonoscopy is currently the preferred screening modality for prevention of colorectal cancer. However, the effectiveness of colonoscopy depends on the quality of the procedure, which depends on several factors. In this paper, we present new methods that derive a new quality metric for automated scoring of quality of mucosa inspection performed by the endoscopist. We conducted Pearsons’ Correlation analysis of the computerized metric scores against the averages of the manual scores given by four domain experts on twenty-one colonoscopy videos. Our metric shows a relatively strong positive correlation (Pearson’s correlation coefficient of 0.72) between the computer-generated score and the ground truth. Hence, the proposed work is very promising to be used for quality control/assurance in routine colonoscopy screening.
Additional Bioactive Compounds and Trilobacin, a Novel Highly Cytotoxic Acetogenin, from the Bark of Asimina triloba (1992)

Fractionation of the EtOH extract of the bark of Asimina triloba, monitoring by brine shrimp lethality, has led to the isolation and structural elucidation of a novel highly cytotoxic Annonaceous acetogenin, trilobacin [1], in addition to six known compounds: asimicin 2], bullatacin [3], bullatacinone [4], N-p-coumaroyltyramine [5], N-trans-feruloyltyramine [6], and (+)-syringaresinol [7]. Acetogenin 1 was identified as a diastereomer of asimicin [2] by spectral and chemical methods, and both 1 and 2 showed potent and selective cytotoxicities in the NCI human tumor cell line screen.
Titanium alloy material with very low outgassing (2003)

In this communication we describe a titanium alloy material that has an excellent low outgassing property whose rate is lower than 6×10−13 Pa m s−1. This value is much lower than that of standard vacuum materials by three orders of magnitude under the same ordinary pretreatments. In our titanium alloy a natural TiO2 thin layer on the surface acts as an enhanced diffusion channel for dissolved gases, mainly hydrogen, consequently very quick evacuation of gas near the surface gives a very low outgassing rate.
Morphology of Peritoneal Dialysis Catheter Tunnel : Macroscopy and Light Microscopy (1991)

There is scanty knowledge of the morphology of peritoneal dialysis catheter tunnels in humans, even though such knowledge may impact on peritoneal catheter design, implantation and postimplantation care. Past descriptions of catheter tunnels are based mainly on data from animal experiments. Based on these data, it has been assumed that epidermal spreading is inhibited by collagen fibers ingrown into the cuff. Our preliminary investigation indicated that this may not be the case in humans and led us to study catheter tunnel morphology in more detail. Eighteen catheter tunnels (2-5mm of tissue around the catheters) were removed in 17 peritoneal dialysis patients. The catheters were inserted 30 to 2013 days prior to removal (median 366 days). The catheters were removed electively or because of infectious or noninfectious complications. Contrary to the observations in animals, in only 1 case did epithelium extend to the cuff with only a minimal amount of granulation tissue present at the end of a 9 mm long sinus tract. In the remaining cases, the leading edge of the epithelium always met granulation tissue 1-14 mm from the exit, and the cuffs were found 8-33 mm from the exit. In tunnels older than 197 days, dense fibrous tissue was ingrown into the cuffs, and a dense fibrous capsule surrounded the cuff. The uninfected intercuff segment formed a pseudosheath, indistinguishable from a tendon sheath or synovial membrane. Infection in the catheter tunnel propagates through the part of the cuff adjacent to the tubing inside the capsule, suggesting that the cuff per se does not constitute a major barrier for spreading infection. This observation, by exclusion, infers that the beneficial role of an external cuff in decreasing exit infections is by providing firm anchorage of the catheter resulting in restriction of its piston like movement and thereby minimizing trauma and inward conveyance of outer sinus tract flora.
Synthesis and antilipolytic activities of quinolyl carbanilates and related analogs (1987)

A series of quinolyl carbanilates was prepared and tested as antilipolytic agents. These compounds inhibited production of glycerol from rat adipocytes and inhibited liberation of free fatty acids from triolein by canine cardiac triglyceride lipases. An extensive structure-activity relationship study indicated that 8-quinolyl 4-methoxycarbanilate (1) contained features necessary for maximum potency in vitro. Substituting a benzofuranyl group for the quinolyl group of 1 provided the most interesting compound on the basis of both potency and structural novelty. 7-Benzofuranyl 4-methoxycarbanilate (44) has IC50's of 16 and 0.3 microM in the myocardial lipase and rat adipocyte assays, respectively. In vivo, compound 44 was orally active as an inhibitor (97% at 25 mg/kg) of lipolysis in the rat.
Evaluation of a Novel Highly Sensitive, Broad-Spectrum PCR-Reverse Hybridization Assay for Detection and Identification of Beta-Papillomavirus DNA (2006)

Human papillomavirus can be detected by amplification of viral DNA. A novel one-step PCR (PM-PCR) was evaluated for amplification of a 117-bp fragment from the E1 region. It permitted ultrasensitive detection of all 25 known human papillomavirus genotypes from the beta-papillomavirus genus. The intra- and intertypic sequence variations of the 77-bp interprimer region were studied. Genotype-specific probes as well as general probes were selected for the 25 established beta-papillomavirus types, and a reverse hybridization assay (RHA) was developed (PM-PCR RHA method). The analytical sensitivity of the PM-PCR RHA method was 10 to 100 viral genomes. The one-step PM-PCR turned out to be more sensitive than the previously described nested MaHa-PCR for beta-papillomavirus detection. The PM-PCR RHA method was able to detect and identify beta-papillomavirus types in frozen patient material as well as in poorly amplifiable material such as formalin-fixed, paraffin-embedded skin biopsy specimens. Inter- and intralaboratory variability experiments showed that the reproducibility of the assay was very high. In conclusion, the one-step PM-PCR together with the RHA allows extremely sensitive, specific, and reproducible detection of beta-papillomavirus DNA as well as reliable identification of beta-papillomavirus genotypes in both fresh and paraffin-embedded patient material.
Pulsed Plasma with Synchronous Boundary Voltage for Rapid Atomic Layer Etching (2014)

Atomic Layer ETching (ALET) of a solid with monolayer precision is a critical requirement for advancing nanoscience and nanotechnology. Current plasma etching techniques do not have the level of control or damage-free nature that is needed for patterning delicate sub-20 nm structures. In addition, conventional ALET, based on pulsed gases with long reactant adsorption and purging steps, is very slow. In this work, novel pulsed plasma methods with synchronous substrate and/or “boundary electrode” bias were developed for highly selective, rapid ALET. Pulsed plasma and tailored bias voltage waveforms provided controlled ion energy and narrow energy spread, which are critical for highly selective and damage-free etching. The broad goal of the project was to investigate the plasma science and engineering that will lead to rapid ALET with monolayer precision. A combined experimental-simulation study was employed to achieve this goal.
Total synthesis of prostaglandins F1.alpha. and E1 (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleTotal synthesis of prostaglandins F1.alpha. and E1Thomas K. Schaaf and E. J. CoreyCite this: J. Org. Chem. 1972, 37, 18, 2921–2922Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/jo00983a037https://doi.org/10.1021/jo00983a037research-articleACS PublicationsRequest reuse permissionsArticle Views340Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Allelic Variant at the <i>ATM</i> Locus Is Implicated in Breast Cancer Susceptibility (1997)

We have tested a simple procedure, disease association by locus stratification, for identifying breast cancer patients with pathogenetic allelic variants at several candidate loci. The strategy was based on the assumption of epistatic interactions of the candidates. We analyzed 66 independent cases from sib pairs affected with breast cancer that had previously been collected during an investigation of pathogenetic-allele-sharing at the HRAS1 mini-satellite locus. An exon 24 polymorphism of ATM, substituting arginine for proline was associated with breast cancer in these cases with an overall odds ratio of 4.5 (95% confidence interval, 1.2-20.5, nominal p = 0.02, 2-tail Fisher exact test). In the presence of a rare HRAS1 allele, the odds ratio increased to 6.9 (95% CI, 1.2-38.3, p = 0.03). Thus, our procedure identified at least one allelic variant of ATM associated with breast cancer, and indicated that the ATM locus may interact with HRAS1.