gebhart/patrepeval huggingface dataset:
Pharmaceutical care for 1 patient with chronic glomerulonephritis (2012)

Objective To discuss the role of clinical pharmacists in clinical practice through the pharmaceutical care for 1 patient with chronic glomerulonephritis.Methods The clinical pharmacists actively assisted physicians in finding out the etiology,putting forward therapeutic schemes,and carrying out pharmaceutical care and education for the patient.Results Pharmaceutical care from clinical pharmacists for patients with chronic glomerulonephritis was helpful for clarifying the etiology,improving patient adherence and healing.Conclusion Clinical pharmacy service can provide effective help in rational drug use.
<i>In Situ</i> Raman Diagnostic of Structural Relaxation Times of Silica Glasses (2011)

High‐purity fused silicas (800–1000 ppm OH) have been studied by in situ Raman scattering in the 1000°–1400°C temperature range, with a particular interest on the behavior under long annealing cycles. We evidence for the first time the relaxation times of silicas in the vicinity of T g by direct monitoring on time–wavenumber 2D representations of the main broad band at 440 cm −1 . These relaxation times appear longer than expected through existing descriptions, and could serve as indicative needed annealing times for thermal treatments and changes of fictive temperature.
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses (2019)

Cytosolic nucleic acid-sensing pathways can be triggered to enhance immune response to cancer. In this study, we tested the antitumor activity of a unique RIG-I agonist, stem loop RNA (SLR) 14. In the immunogenic tumor models, we observed significant tumor growth delay and an extended survival in SLR14-treated mice. SLR14 also greatly improved antitumor efficacy of anti-PD1 antibody over single-agent treatment. SLR14 was mainly taken up by CD11b<sup>+</sup> myeloid cells in the tumor microenvironment, and many genes associated with immune defense were significantly up-regulated after treatment, accompanied by increase in the number of CD8<sup>+</sup> T lymphocytes, NK cells, and CD11b<sup>+</sup> cells in SLR14-treated tumors. Strikingly, SLR14 dramatically inhibited nonimmunogenic B16 tumor growth, and the cured mice developed an immune memory. Furthermore, a systemic antitumor response was observed in both bilateral and tumor metastasis models. Collectively, our results demonstrate that SLR14 is a promising therapeutic RIG-I agonist for cancer treatment, either alone or in combination with existing immunotherapies.
The Chimaera Ontology Environment (2000)

Ontologies have become central components in many applications including search, e-commerce, configuration and, arguably, every large web site (at least for organization and navigation). As ontologies become larger, more distributed, and longer-lived, the need for ontology creation and maintenance environments grows. In our work with ontologies and tool environments over the last few years, we have observed growing needs for automated support of two tasks: (1) merging multiple ontologies and (2) diagnosing (and evolving) ontologies. Chimaera is aimed at supporting these two tasks.
Hybrid Au–SiO<sub>2</sub>Core–Satellite Colloids as Switchable SERS Tags (2015)

Gold–silica self-assembled nanostructures are reported as multiplex surface enhanced Raman scattering (SERS) tags for bioimaging applications. These hybrid colloidal particles were obtained by heteroassembly of Au–SiO2 Janus particles with smaller Au spheres and two Raman-active molecules that can be independently imaged by varying the wavelength of the excitation laser. The Janus structure of Au–SiO2 not only directs the assembly but also provides physical separation of the Raman tags and colloidal stability thereby facilitating complete silica encapsulation. The bioimaging capabilities of this system are demonstrated through SERS mapping of individual cells.
Validated HPLC Method for Quantification of Pregabalin in Human Plasma Using 1-Fluoro-2,4-dinitrobenzene as Derivatization Agent (2014)

In this study, a sensitive, simple, and reliable HPLC method for quantification of pregabalin in human plasma was developed and validated. 1-Fluoro-2,4-dinitrobenzene was used as precolumn derivatization agent. For chromatography, an analytical reversed phase (C18) column and a mixture of Na 2 HPO 4 10 mM (pH 8.0)—methanol (35 : 65 v/v) were used as stationary and mobile phase, respectively. Detection was performed using a UV detector tuned at 360 nm. The linearity of the method was tested over the concentration range 1–4500 ng/mL in 500 μ L of human plasma and satisfactory results were obtained ( r 2 > 0.999). The method showed good precision and accuracy in terms of within—between days relative standard deviations and percent deviation from nominated values (in the range of 4.3–12.7% and 2.6–8.0%, resp.). The limit of quantification of the method was found to be 1 ng/mL which is better than previously reported method and indicates its potential application for sensitive bioanalysis.
Preparation and use of W(CO)3(NCR)3 (R = Et, Pr) as improved starting materials for syntheses of tricarbonyl(.eta.6-cycloheptatriene)tungsten and other substituted carbonyl complexes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and use of W(CO)3(NCR)3 (R = Et, Pr) as improved starting materials for syntheses of tricarbonyl(.eta.6-cycloheptatriene)tungsten and other substituted carbonyl complexesGregory J. KubasCite this: Inorg. Chem. 1983, 22, 4, 692–694Publication Date (Print):February 1, 1983Publication History Published online1 May 2002Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/ic00146a025https://doi.org/10.1021/ic00146a025research-articleACS PublicationsRequest reuse permissionsArticle Views1065Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Combinatorial expression of different β-carotene hydroxylases and ketolases in <i>Escherichia coli</i> for increased astaxanthin production (2019)

Abstract In natural produced bacteria, β-carotene hydroxylase (CrtZ) and β-carotene ketolase (CrtW) convert β-carotene into astaxanthin. To increase astaxanthin production in heterologous strain, simple and effective strategies based on the co-expression of CrtZ and CrtW were applied in E. coli. First, nine artificial operons containing crtZ and crtW genes from different sources were constructed and, respectively, introduced into E. coli ZF237T, a β-carotene producing host. Among the nine resulting strains, five accumulated detectable amounts of astaxanthin ranging from 0.49 to 8.07 mg/L. Subsequently, the protein fusion CrtZ to CrtW using optimized peptide linkers further increased the astaxanthin production. Strains expressing fusion proteins with CrtZ rather than CrtW attached to the N-terminus accumulated much more astaxanthin. The astaxanthin production of the best strain ZF237T/CrtZAs-(GS)1-WBs was 127.6% and 40.2% higher than that of strains ZF237T/crtZ As W Bs and ZF237T/crtZ Bs W Ps, respectively. The strategies depicted here also will be useful for the heterologous production of other natural products.
보호작업장에서의 직업평가에 관한 연구 (2002)

본 연구는 보호작업장에서의 직업평가에 관한 이론적 토대를 구명하는데 그 목적이 있다. 이를 구체적으로 구명하기 위하여 보호작업장의 의의와 현직평가, 보호작업장에서의 행동평가를 중심으로 보호작업장에서의 직업평가의 의의를 밝혔고, 행동관찰에 관한 일반적 절차, 행동관찰의 방법을 중심으로 한 보호작업장에서의 평가 방법을 구명하였으며, 작업행동 관찰사실의 분석 및 해석, 평가의 양식과 적용을 중심으로 한 관찰 사실의 분석 · 해석 및 평가양식의 적용을 구명하였다. 최근의 동향을 볼 때에 지원고용이 채택되어 실시되고 있지만, 현실적으로 보면, 아직도 보호고용 형태를 유지하고 있으며, 보호작업장에서의 교육 ·훈련을 평가한 후 통합고용인 지원고용으로 이행되는 형태가 많이 이루어지고 있다. 본 연구의 결과는 앞으로의 보호작업장에서의 직업훈련 후 지원고용으로의 전이계획수립에 있어서 이론적 기초를 제공하며, 그 실천면에 맡은 시사점을 제공해줄 것이라 사료된다.
Data transmission over UHF fading mobile radio channels (1984)

A combination of transparent tone-in-band (TTIB) and feedforward signal regeneration (FFSR) audio signal-processing techniques enable the efficient transmission of speech and data communications over mobile radio links, and amplitude companded pilot tone single sideband (SSB) in particular. The contribution is concerned primarily with data communications, coherent and noncoherent, over such networks in the presence of multipath induced amplitude and phase distortion. A detailed consideration of the properties of the combined TTIB/FFSR system show it to have several significant advantages over data-derived reference schemes.
Focal Therapy and Imaging in Prostate and Kidney Cancer: High-Intensity Focused Ultrasound Ablation of Small Renal Tumors (2010)

The rising incidence of small, incidentally detected renal masses in elderly, infirm patients has raised interest in minimally invasive, energy ablative techniques. High-intensity focused ultrasound (HIFU) delivers ultrasonic energy, resulting in heat and tissue destruction in the targeted tissue at a selected depth. In contrast to radiofrequency ablation and cryoablation, HIFU does not require puncturing the tumor, avoiding the high risk of hemorrhage or tumor spillage. While the extracorporeal approach shows unsatisfactory results, laparoscopic HIFU appears to be a promising alternative treatment option. Problems with respiratory movement and interphases, as seen in extracorporeal HIFU, are avoided when the transducer is brought directly to the target by laparoscopic HIFU. Potential benefits of laparoscopic HIFU are decreased morbidity, shorter hospitalization and convalescence, and preservation of renal function. Nevertheless, further prospective studies have to be performed to define the oncological success of HIFU as an alternative to open and laparoscopic surgery in small renal masses.
Cloning of Two Putative Ecdysteroid Receptor Isoforms from <i>Tenebrio Molitor</i> and their Developmental Expression in the Epidermis during Metamorphosis (1997)

Using the Drosophila EcR-B1 cDNA as a probe, we have cloned the putative ecdysteroid receptor from the mealworm Tenebrio molitor. We have isolated two cDNAs with different 5' termini that contain a complete open reading frame. These two cDNAs encode two proteins with distinct N-terminal regions corresponding to two isoforms. The coleopteran receptor is obviously related to the ecdysteroid receptor of other insects, but shares only 89% and 61% amino acid identities with the DNA-binding and ligand-binding domains of the Drosophila receptor, respectively. Its expression pattern has been examined in the epidermis during the last larval instar and pupal stage of T. molitor, in correlation with the hemolymph ecdysteroid titer. Hybridizations revealed two transcripts of 7 kb and 6.5 kb detected in most stages during metamorphosis and corresponding to the A and B1 isoforms. These two mRNAs are highly evident just before the rise of each ecdysteroid peak both in prepupae and in pupae. They show almost the same expression pattern in epidermis except for the second part of the pupal stage, during which only the A isoform is detected.
Adding Acknowledgement Congestion Control to TCP (2010)

This document describes a possible congestion control mechanism for acknowledgement (ACKs) traffic in TCP. The document specifies an end-to-end acknowledgement congestion control mechanism for TCP that uses participation from both TCP hosts: the TCP data sender and the TCP data receiver. The TCP data sender detects lost or Explicit Congestion Notification (ECN)-marked ACK packets, and tells the TCP data receiver the ACK Ratio R to use to respond to the congestion on the reverse path from the data receiver to the data sender. The TCP data receiver sends roughly one ACK packet for every R data packets received. This mechanism is based on the acknowledgement congestion control in the Datagram Congestion Control Protocol's (DCCP's) Congestion Control Identifier (CCID) 2. This acknowledgement congestion control mechanism is being specified for further evaluation by the network community.
A Fiberoptic Stylette for Localizing the Balloon Buckle (1990)

A third-generation balloon catheter that accepts a fiberoptic has been developed. The fiberoptic is inserted through the catheter to the center of the balloon when the balloon is in the area of the retinal break. Viewed with the ophthalmoscope light at dim to off, the balloon can be seen glowing through the wall of the eye. The position of the balloon can then be shifted until the glow is precisely under the retinal break.
A Multicolor Saccharide Sensing Chip Created by Layer-by-Layer Adsorption of a Boronic Acid-containing Polymer (2012)

A novel saccharide sensor array that shows distinct color change was developed. By the layer-by-layer method utilizing boronic acid-containing polycation and polyanion, saccharide-responsive thin films were obtained on a pattern-printed microscope slide. After adsorbing anionic dyes, the thin films were immersed in aqueous saccharide solutions. As saccharide concentration increased, the thin films clearly changed their color. Since the color changed occurred at different saccharide concentrations depending on anionic dyes, the sensor array showed a multipactor color change which enables us to quantify saccharides by a pattern-based sensing.
Cataluña, más allá del 1 de Octubre: El Siglo reúne a PP, PSOE, Podemos, Cs y PDeCAT para debatir sobre la crisis catalana y sus posibles salidas (2017)

A apenas unos dias del 1-O, portavoces de los principales partidos politicos con representacion en el Congreso de los Diputados y el Parlament catalan se han sentado a la mesa de debate de El Siglo: Alejandro Fernandez (PP), Andres Perello (PSOE), Joan Mena (En Comu Podem), Fernando Navarro (Ciudadanos), y Carles Campuzano (PDeCAT), han defendido sus posturas en uno de Los debates de El Siglo celebrado en el Centro Cultural Blanquerna, en Madrid, sobre como ven el tenso momento politico que vive Espana en torno al 1 de Octubre, por que se ha producido a este conflicto politico en Cataluna, cuales pueden ser las posibles soluciones. Pese a la enorme distancia en las posiciones, todos abogaron por el dialogo tras el fatidico domingo.
Mass propagation of globe artichoke (Cynara scolymus): Evaluation of different hypotheses to overcome vitrification with special reference to water potential (1981)

In search of a technique for rapid clonal propagation and sanitation of Cynara scolymus L. we have been confronted with the problem of vitrification. We only succeeded in overcoming this problem by raising the agar concentration of our medium to 1.1% instead of 0.6%. By using the Chardakov‐method and direct measurement of the water potential with a thermocouple psychrometer we were able to prove that this result was attributable to the matric potential.
Supramolecular Surface Immobilization of Knottin Derivatives for Dynamic Display of High Affinity Binders (2015)

Knottins are known as a robust and versatile class of miniprotein scaffolds for the presentation of high-affinity binding peptides; however, to date their application in biomaterials, biological coatings, and surface applications have not been explored. We have developed a strategy to recombinantly synthesize a β-trypsin inhibitory knottin with supramolecular guest tags that enable it to adhere to self-assembled monolayers of the supramolecular host cucurbit[8]uril (CB[8]). We have described a strategy to easily express knottins in E. coli by conjugating them to a fluorescent protein after which they are cleaved and purified. Knottin constructs that varied in the number and position of the supramolecular tag at either the N- or C-termini or at both ends have been verified for their trypsin inhibitory function and CB[8]-binding properties in solution and on surfaces. All of the knottin constructs showed strong inhibition of trypsin with inhibition constants between 10 and 30 nM. Using microscale thermophoresis, we determined that the supramolecular guest tags on the knottins bind CB[8] with a Kd of ∼6 μM in solution. At the surface, strong divalent binding has been determined with a Kd of 0.75 μM in the case of the knottin with two supramolecular guest tags, whereas only weak monovalent binding occurred when only one guest tag was present. We also show successful supramolecular surface immobilization of the knottin using CB[8] and prove that they can be used to immobilize β-trypsin at the surface.
Combining Undersampled Dithered Images (1999)

Undersampled images, such as those produced by the HST WFPC-2, misrepresent fine-scale structure intrinsic to the astronomical sources being imaged. Analyzing such images is difficult on scales close to their resolution limits and may produce erroneous results. A set of ``dithered'' images of an astronomical source generally contains more information about its structure than any single undersampled image, however, and may permit reconstruction of a ``superimage'' with Nyquist sampling. I present a tutorial on a method of image reconstruction that builds a superimage from a complex linear combination of the Fourier transforms of a set of undersampled dithered images. This method works by algebraically eliminating the high order satellites in the periodic transforms of the aliased images. The reconstructed image is an exact representation of the data-set with no loss of resolution at the Nyquist scale. The algorithm is directly derived from the theoretical properties of aliased images and involves no arbitrary parameters, requiring only that the dithers are purely translational and constant in pixel-space over the domain of the object of interest. I show examples of its application to WFC and PC images. I argue for its use when the best recovery of point sources or morphological information at the HST diffraction limit is of interest.
Aerosol‐Jet Printing of Polymer‐Sorted (6,5) Carbon Nanotubes for Field‐Effect Transistors with High Reproducibility (2017)

Single‐walled carbon nanotubes (SWNTs) are a promising material for flexible and printed electronics. Efficient dispersion and sorting methods facilitate the production of large quantities of high‐quality semiconducting SWNT inks for direct printing. Here, the suitability of aerosol‐jet printing of polymer‐sorted (6,5) SWNTs for top‐gate field‐effect transistors is investigated. Despite the sonication involved in the printing process, almost no impact on the quality of the SWNTs in terms of defects and length is found. Printed network transistors show reproducible device performance over extended printing periods and for different ink batches with constant printing parameters. Deposition of multiple SWNT layers to obtain thicker and optically dense films increases the effective mobility and on‐conductance, while also decreasing hysteresis. Aerosol‐jet printing of SWNTs is thus suitable for the fabrication of integrated circuits based on nanotube transistors.
Integration of <i>Agrobacterium tumefaciens</i> transfer DNA (T-DNA) involves rearrangements of target plant DNA sequences (1987)

The transfer DNA (T-DNA) mobilized into plant cells by Agrobacterium tumefaciens seems to integrate rather randomly into the plant genome. We analyzed a target site in the genome of Nicotiana tabacum before and after integration of a T-DNA. Clones presenting right and left T-DNA/plant DNA junctions were used as probes to identify and isolate a unique 1.8-kilobase EcoRI fragment corresponding to the plant DNA target site for a T-DNA insertion event. Comparison of the nucleotide sequences of the plant DNA portions of the T-DNA junction clones with the original plant DNA target revealed that several types of rearrangements resulted from insertion of the T-DNA. The most dramatic alteration was a 158-base-pair direct repeat of target plant sequences at the left and right T-DNA junctions. In addition, there were deletion and insertion events at the ends of the right and left copies of the 158-base-pair repeat. The variety of target-site rearrangements suggests that T-DNA insertion is a multistep process of recombination accompanied by local replicative and repair activities mediated by host-cell enzymes.
Exploiting Service Usage Information for Optimizing Server Resource Management (2011)

It is often difficult to tune the performance of modern component-based Internet services because: (1) component middleware are complex software systems that expose several independently tuned server resource management mechanisms; (2) session-oriented client behavior with complex data access patterns makes it hard to predict what impact tuning these mechanisms has on application behavior; and (3) component-based Internet services themselves exhibit complex structural organization with requests of different types having widely ranging execution complexity. In this article we show that exposing and using detailed information about how clients use Internet services enables mechanisms that achieve two interconnected goals: (1) providing improved QoS to the service clients, and (2) optimizing server resource utilization. To differentiate among levels of service usage (service access) information, we introduce the notion of the service access attribute and identify four related groups of service access attributes, encompassing different aspects of service usage information, ranging from the high-level structure of client web sessions to low-level fine-grained information about utilization of server resources by different requests. To show how the identified service usage information can be collected, we implement a request profiling infrastructure in the JBoss Java application server. In the context of four representative service management problems, we show how collected service usage information is used to improve service performance, optimize server resource utilization, or to achieve other problem-specific service management goals.
Accurate estimation of pharmacokinetic contrast‐enhanced dynamic MRI parameters of the prostate (2001)

Quantitative analysis of contrast-enhanced dynamic MR images has potential for diagnosing prostate cancer. Contemporary fast acquisition techniques can give sufficiently high temporal resolution to sample the fast dynamics observed in the prostate. Data reduction for parametric visualization requires automatic curve fitting to a pharmacokinetic model, which to date has been performed using least-squares error minimization methods. We observed that these methods often produce unexpectedly noisy estimates, especially for the typically fast, intermediate parameters time-to-peak and start-of-enhancement, resulting in inaccurate pharmacokinetic parameter estimates. We developed a new curve fit method that focuses on the most probable slope. A set of 10 patients annotated using histopathology was used to compare the conventional and new methods. The results show that our new method is significantly more accurate, especially in the relatively less-enhancing peripheral zone. We conclude that estimation accuracy depends on the curve fit method, which is especially important when evaluating the peripheral zone of the prostate.