gebhart/patrepeval huggingface dataset:
Silk Fibroin Biosensor Based on Imprinted Periodic Nanostructures (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. J. Amsden, A. Gopinath, L. D. Negro, D. L. Kaplan, and F. G. Omenetto, "Silk Fibroin Biosensor Based on Imprinted Periodic Nanostructures," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper CFP5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Statistical Moments Based Universal Steganalysis using JPEG 2-D Array and 2-D Characteristic Function (2006)

Owing to the popular usage of JPEG images, the steganographic tools for JPEG images emerge increasingly nowadays, among which OutGuess, F5, and the model based steganography are the most advanced. Advancing the previous work, we present a new universal steganalysis method based on statistical moments derived from both image 2-D array and JPEG 2-D array in this paper. In addition to the first order histogram, the second order histogram is considered. Consequently, the moments of 2-D characteristic functions are also used for steganalysis. Extensive experimental works have shown that the proposed method outperforms in general the prior-arts of steganalysis methods in attacking the three aforesaid steganographic schemes.
The Asn9 variant of lipoprotein lipase is associated with the -93G promoter mutation and an increased risk of coronary artery disease (1998)

Two mutations in the lipoprotein lipase (LPL) gene, a T to G transition at position -93 of the proximal promoter region and an Asp9Asn substitution in exon 2, were examined in 762 Dutch males with angiographically-diagnosed coronary artery disease (CAD) and 296 healthy normolipidemic Dutch males. The two mutations exhibited strong linkage disequilibrium (D' = 0.975). A significantly higher proportion of cases (4.86%) than controls (1.37%) carried the -93G/Asn9 allele (p = 0.008). In the combined sample of cases and controls, adjusted mean plasma total cholesterol (TC) levels were significantly higher in -93G/Asn9 carriers (6.20+/-0.13 mmol/l) than in non-carriers (5.93+/-0.03 mmol/l; p = 0.048), while mean high-density lipoprotein cholesterol (HDL-C) levels were lower in carriers (0.88+/-0.03 mmol/l) than in non-carriers (0.98+/-0.01 mmol/l; p = 0.002). There was a trend towards higher triglyceride (TG) levels in carriers (1.96+/-0.14 mmol/l) compared with non-carriers (1.73+/-0.03 mmol/l) (p = 0.08). Additionally, carrier frequencies in tertiles of TC, HDL-C, TG, and LPL activity, suggested an association of the -93G/Asn9 variant with higher TC and TG levels, and with lower HDL-C and LPL activity levels. Logistic regression revealed a significant odds ratio (OR) for the combined -93G/Asn9 genotype in CAD cases relative to controls (OR: 5.36; 95% CI: 1.57-18.24), with age, body mass index (BMI), smoking, and plasma total- and HDL-cholesterol levels included in the model. In conclusion, we show that the LPL Asp9Asn mutation is in non-random association with a T G substitution at position -93 of the proximal promoter region and that the combined -93G/Asn9 genotype predisposes to decreased HDL-C levels and an increased risk of CAD.
Color Subspaces as Photometric Invariants (2006)

Complex reflectance phenomena such as specular reflections confound many vision problems since they produce image ‘features’ that do not correspond directly to intrinsic surface properties such as shape and spectral reflectance. A common approach to mitigate these effects is to explore functions of an image that are invariant to these photometric events. In this paper we describe two such invariants" one invariant to specular reflections, and the other invariant to both specular reflections and diffuse shading" that result from exploiting color information in images of dichromatic surfaces. These invariants are derived from subspaces of RGB color space, and they enable the application of Lambertian-based vision techniques to a broad class of specular, non-Lambertian scenes. Using implementations of recent algorithms taken from the literature, we demonstrate the practical utility of these invariants for a wide variety of applications, including stereo, shape from shading, material-based segmentation, and motion estimation.
Comparison of Binding Affinity of Oxytocin Antagonists to Human and Rat Uterine Oxytocin Receptors and their Correlation to the Rat Uterine Oxytocic Bioassay1 (1994)

One of the primary methods used to screen the development of oxytocin antagonists (OTAs) is the rat oxytocic bioassay. The purpose of this study was to determine whether the rat oxytocic bioassay is a good predictor of binding affinity to human and rat uterine oxytocin receptors (OTr). The binding affinities of five OTAs to human and rat uterine OTr were determined and correlated with pA2 values derived from the rat uterine oxytocic bioassay. Human uterine myometrial tissue was obtained from patients at the time of cesarean section. Rat uterine tissue for the OTr assay was taken at Day 21 of pregnancy. OTr assays were accomplished by isolating uterine cell membranes and performing saturation analysis with cold OTAs and tritium-labeled oxytocin. The association constants (Ka; 10(+8)/M) were calculated by nonlinear curve-fitting techniques. The Ka for the five OTAs (Mpa1-OT, Antag I, L366948, Antag II, and Antag III), as estimated from the human OTr assay, were 0.55, 0.60, 2.27, 1.91, and 47.20, respectively. Ka estimates obtained through use of rat uterine membranes were 0.51, 1.16, 5.89, 2.03, and 24.40, respectively. Correlation of the log10 of the rat oxytocic bioassay results with those of the rat and human OTr assay was 0.94 and 0.98, respectively (p < 0.01). Antag III was approximately 55, 48, and 90 times more potent than Mpa1-OT as determined by the rat bioassay and rat and human uterine OTr assays, respectively. Mpa1-OT is an OTA that is currently undergoing clinical evaluation.(ABSTRACT TRUNCATED AT 250 WORDS)
High Power Pump Laser (2004)

High power pump laser diodes at various wavelengths, mainly around 980 nm, are key elements in today’s optical amplifier architectures. The status of Bookham’s telecom-laser technology is reviewed and latest developments of transversal single- and multi-mode pump lasers are presented.
Partial Proteolytic Digestion of the Mammary Prolactin Receptor: Identification of Smaller Prolactin Binding Fragments (1989)

Partial proteolytic digestion of the mammary prolactin (PRL) receptor was used to generate receptor fragments and analyze their immunoreactivity and PRL binding properties. Tryptic digestion of the PRL receptor produced two immunoreactive fragments (Mr approximately 30,000 and approximately 15,000) that reacted with a monoclonal anti-PRL receptor antibody and still specifically bound PRL, while the complete immunoreactive PRL binding unit (Mr approximately 42,000) disappeared. Neither chymotrypsin nor V8 protease were able to generate any immunoreactive receptor fragments. These receptor fragments may represent smaller PRL binding receptor form(s) of biological significance.
Abstract 17734: Functional Cardiac Fibroblasts Derived From Human Pluripotent Stem Cells via Second Heart Field Progenitors (2017)

Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. The sparse availability of human CFs from the native heart limits studies investigating their biology a...
Abstract 462: Soluble CD80 restores T-cell activation and overcomes tumor cell programmed death ligand-1-mediated suppression. (2013)

Abstract Many tumor cells escape anti-tumor immunity through their expression of Programmed Death Ligand 1 (PDL1 or B7-H1), which interacts with T cell-expressed PD1 and results in T cell apoptosis. We previously reported that transfection of human tumor cells with a membrane-bound form of the costimulatory molecule CD80 prevented PD1 binding and restored T cell activation. We now report that membrane-bound CD80 similarly reduces PDL1-PD1-mediated suppression by mouse tumor cells, and that a fusion protein consisting of the extracellular domains of CD80 fused to an Fc domain of IgG1 overcomes PDL1-mediated suppression by human tumor cells. T cell activation experiments assessing costimulation indicate that the soluble CD80 fusion protein mediates its effects by binding to PDL1 and inhibiting PDL1-PD1 interactions. Comparison of the CD80 fusion protein to antibodies specific for PD1 or PDL1 demonstrate that soluble CD80 treatment is more effective in restoring T cell activation than treatment with mAb to either PD1 or PDL1. These studies identify soluble CD80 as an alternative and potentially more efficacious therapeutic agent for overcoming PDL1-induced immune suppression and facilitating tumor-specific immunity. Citation Format: Samuel Haile, Sonia P. Dalal, Virginia Clements, Koji Tamada, Suzanne Ostrand-Rosenberg. Soluble CD80 restores T-cell activation and overcomes tumor cell programmed death ligand-1-mediated suppression. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 462. doi:10.1158/1538-7445.AM2013-462
Drug Delivery at the Aortic Valve Tissues of Healthy Domestic Pigs with a Paclitaxel‐Eluting Valvuloplasty Balloon (2009)

Local drug delivery at the aortic valve leaflets of healthy pigs with a paclitaxel-eluting balloon is feasible and concentrations within the therapeutic window are detected 30 minutes after the procedure. The antirestenotic potential of this treatment should be studied.
Effectiveness of a cytolysin-enriched vaccine for protection of cattle against infectious bovine keratoconjunctivitis (2005)

Calves that were vaccinated with a cytolysin-enriched vaccine had some resistance to IBK. Vaccines containing concentrated diafiltered M bovis cytolysin could protect beef calves against IBK.
New approaches in catalyst manufacture (1986)

Changes in both petroleum refinery feedstocks and refinery product slates during the past 10 years have necessitated new approaches in catalyst manufacture. New hydrotreating catalysts are expected to improve polynuclear aromatic saturation, and to increase cetane index, mild hydrocracking, asphaltene conversion, and contaminant metal removal. Sulfur and nitrogen removal were once considered the sole benefits of hydroprocessing. To accommodate these needs, catalyst manufacturers have focused added attention on defining and achieving rigorous physical and chemical specifications for each new catalyst. It is considered essential to continually improve quality and process control in each manufacturing step. In addition, manufacturers have introduced new technology both in the process and in the evaluation of product. The importance of pore size distribution (PSD), for example, has been appreciated for 20 years or more but it is only within the past 10 years that routine measurement of PSD by mercury and/or nitrogen porosimetry has been applied throughout the entire manufacturing process. A greater emphasis on heavy oil hydrotreating has spurred demands for wide pore catalysts of small external dimensions to overcome the problems of diffusion-limited reactions. In turn, however, these properties may create problems with crush strength and catalyst attrition.
A magnetic nanocomposite for biomimetic flow sensing (2014)

A magnetic nanocomposite has been implemented as artificial hair on a giant magnetoimpedance (GMI) thin-film sensor for flow sensing. The 500 μm long and 100 μm in diameter pillars are composed of iron nanowires incorporated in polydimethylsiloxane (PDMS). The nanowires' length and diameter are 6 μm and 35 nm, respectively. Upon fluid flow, the pillars are deflected, causing a change in the magnetic field at the GMI element and a corresponding change in impedance. The permanent magnetic behavior of the nanowires in combination with the GMI sensor and the high elasticity of the PDMS pillars result in a high-performance flow sensor with low power consumption and potential for remote detection. No additional magnetic field is required to magnetize the nanowires or bias the sensor, which simplifies miniaturization and integration in microsystems. At a power consumption of 31.6 μW, air flow rates up to 190 mm s(-1) can be detected with a sensitivity of 24 mΩ (mm)(-1) s and a resolution of 0.56 mm s(-1) while the range for water flow is up to 7.8 mm s(-1) with a sensitivity of 0.9 Ω (mm)(-1) s and a resolution of 15 μm s(-1). When power consumption is reduced to as low as 80 nW a high resolution of 32 μm s(-1) is still maintained.
Molecular engineering of a polymer of tetrameric hemoglobins (2001)

We have engineered a recombinant mutant human hemoglobin, Hb Prisca beta(S9C+C93A+C112G), which assembles in a polymeric form. The polymerization is obtained through the formation of intermolecular S-S bonds between cysteine residues introduced at position beta9, on the model of Hb Porto Alegre (beta9Ser --> Cys) (Bonaventura and Riggs, Science 1967;155:800-802). Cbeta93 and Cbeta112 were replaced in order to prevent formation of spurious S&bond;S bonds during the expression, assembly, and polymerization events. Dynamic light scattering measurements indicate that the final polymerization product is mainly formed by 6 to 8 tetrameric hemoglobin molecules. The sample polydispersity Q = 0.07 +/- 0.02, is similar to that of purified human hemoglobin (Q = 0.02 +/- 0.02), consistent with a good degree of homogeneity. In the presence of strong reducing agents, the polymer reverts to its tetrameric form. During the depolymerization process, a direct correlation is observed between the hydrodynamic radius and the light scattering of the system, which, in turn, is proportional to the mass of the protein. We interpret this to indicate that the hemoglobin molecules are tightly packed in the polymer with no empty spaces. The tight packing of the hemoglobin molecules suggests that the polymer has a globular shape and, thus, allows estimation of its radius. An illustration of an arrangement of a finite number of tetrameric hemoglobin molecules is presented. The conformational and functional characteristics of this polymer, such as heme pocket conformation, stability to denaturation, autoxidation rate, oxygen affinity, and cooperativity, remain similar to those of tetrameric human hemoglobin.
On Privacy-Preservation of Text and Sparse Binary Data with Sketches (2007)

In recent years, privacy preserving data mining has become very important because of the proliferation of large amounts of data on the internet. Many data sets are inherently high dimensional, which are challenging to different privacy preservation algorithms. However, some domains of such data sets also have some special properties which make the use of sketch based techniques particularly useful. In this paper, we present a new method for privacy preserving data mining of text and binary data with the use of a sketch based approach. The special properties of such data sets which are exploited are that of sparsity; according to this property, only a small percentage of the attributes have non-zero values. We formalize an anonymity model for the sketch based approach, and utilize it in order to construct sketch based privacy preserving representations of the original data. This representation allows accurate computation of a number of important data mining primitives such as the dot product. Therefore, it can be used for a variety of data mining algorithms such as clustering and classification. We illustrate the effectiveness of our approach on a number of real and synthetic data sets. We show that the accuracy of data mining algorithms is preserved by the transformation even in the presence of increasing data dimensionality.
A novel frequency transition scheme for capacity enhancement in a cellular radio system (2002)

This paper presents a smooth transition scheme for frequency planning when capacity enhancement is envisaged in existing AMPS-TDMA cellular networks. To meet growth requirements, it is often required to adopt reuse schemes with smaller reuse distances, and this in turn results in modification of the existing frequency plan. The proposed frequency transition scheme allows for gradual expansion, smooth transition and also unobtrusive co-existence offering minimal disturbance to the existing network. The plan also allows fractional reduction in cluster size and has the flexibility to adapt to varying traffic growth requirements.
In-Situ Real-Time Characterization of Particulate Emissions from a Diesel Engine Exhaust by Laser-Induced Incandescence (2000)

<div class="htmlview paragraph">Diesel engines face tightening particulate matter emissions regulations due to the environmental and health effects attributed to these emissions. There is increasing demand for measuring not only the concentration, but also the size distribution of the particulates. Laser-induced incandescence has emerged as a promising technique for measuring spatially and temporally resolved particulate volume fraction and size. Laser-induced incandescence has orders of magnitude more sensitivity than the gravimetric technique, and thus offers the promise of real-time measurements and adds the increasingly desirable size and morphology information.</div> <div class="htmlview paragraph">The usefulness of LII as a diagnostic instrument for the precise measurement of particulate concentration and primary particle size has been demonstrated. Measurements have been performed in the exhaust of a single cylinder DI research diesel engine. Simultaneous gravimetric filter measurements were made for direct comparison with the LII technique. Quantitative LII is shown to provide a sensitive, precise, and repeatable measure of the particulate concentration over a wide dynamic range. LII and gravimetric measurements are shown to correlate well over a wide range of operating conditions. A novel method for determining the primary particle size is shown to be precise enough to distinguish particle sizes for different engine operating conditions, and subsequently the number density of primary particles was determined. LII has also been shown to be sensitive in differentiating the PM performance between four different fuels.</div> <div class="htmlview paragraph">The LII technique is capable of real-time particulate matter measurements over any engine transient operation. The wide dynamic range and lower detection limit of LII make it a potentially preferred standard instrument for particulate matter measurements.</div>
Effect of pulse asymmetry and nonlinear chirp on the accuracy of ultrafast pulsed laser interferometry (2017)

Ultrafast pulsed laser interferometry (PLI) can measure picometer displacements at sub-nanosecond time scales, such as acoustic waves and vibrations in microstructures. In this Letter, the effects of pulse characteristics on the accuracy of PLI are investigated through measurements and modeling. The results show that the effective wavelength of PLI, λ<sub>eff</sub>, varies significantly as a function of overlap between the interfering pulses due to pulse asymmetry and nonlinear chirp. This variation presents a serious limitation on the accuracy of PLI if unaddressed. However, it is shown that a continuous-wave laser interferometer can be used to determine λ<sub>eff</sub> with an uncertainty near 0.01%, making it possible to use PLI for accurate displacement measurements.
A tool to detect external cracks from within a metal tube (1997)

A tool using a continuous electromagnetic wave from a transverse magnetic-dipole source with a coaxial electric-dipole receiver is outlined for the detection of external sidewall cracks in boiler tubes. A numerical study of the distribution of the fields shows that the direct transmission from the source to the receiver is reduced from that in free space. Further, if the diameter of the receiver dipole is made sufficiently small, it should be possible to detect cracks with a scattering loss of up to 40dB in thin-walled boiler tubes.
The synthesis and preclinical evaluation in rhesus monkey of [<sup>18</sup>F]MK‐6577 and [<sup>11</sup>C]CMPyPB glycine transporter 1 positron emission tomography radiotracers (2010)

Two positron emission tomography radiotracers for the glycine transporter 1 (GlyT1) are reported here. Each radiotracer is a propylsulfonamide-containing benzamide and was labeled with either carbon-11 or fluorine-18. [¹¹C]CMPyPB was synthesized by the alkylation of a 3-hydroxypyridine precursor using [¹¹C]MeI, and [¹⁸F]MK-6577 was synthesized by a nucleophilic aromatic substitution reaction using a 2-chloropyridine precursor. Each tracer shows good uptake into rhesus monkey brain with the expected distribution of highest uptake in the pons, thalamus, and cerebellum and lower uptake in the striatum and gray matter of the frontal cortex. In vivo blockade and chase studies of [¹⁸F]MK-6577 showed a large specific signal and reversible binding. In vitro autoradiographic studies with [¹⁸F]MK-6577 showed a large specific signal in both rhesus monkey and human brain slices and a distribution consistent with the in vivo results and those reported in the literature. In vivo metabolism studies in rhesus monkeys demonstrated that only more-polar metabolites are formed for each tracer. Of these two tracers, [¹⁸F]MK-6577 was more extensively characterized and is a promising clinical positron emission tomography tracer for imaging GlyT1 and for measuring GlyT1 occupancy of therapeutic compounds.
Assessment of the viral RNA sequence heterogeneity for control of OPV neurovirulence. (1993)

By using sensitive mutant analysis by PCR and restriction enzyme cleavage we have found that among several positions that differ between the wild-type and attenuated type 3 poliovirus genomes, only two positions, 472 and 2493, showed variability in vaccine lots. Of these two, only position 472 correlates with neurovirulence in monkeys, while the abundance of revertants at position 2493 indicated the type of seed virus and the passage level. Conditions of cell culture influence the rate of mutant selection, suggesting that some cellular factor(s) may be involved in selection of 472-C. Determination of 472-C content predicts which vaccine lots would fail the monkey neurovirulence test. These results imply that the PCR method can be used for optimization of manufacturing conditions.
Harmonic compensation using a synchronous machine with resonant field circuits (1997)

This paper deals with a harmonic compensation method using a synchronous machine with resonant field circuits. Harmonics have become one of the major problems in power systems and a lot of methods of harmonic suppression have been studied. The authors have proposed a new method of harmonic suppression using a synchronous machine excited with the 6th harmonic current. This paper shows that armature inductances for the 5th or 7th harmonics decrease when the field circuits are connected to capacitors resonating at the 6th harmonic. The variations of armature impedances are explained theoretically by Park's equations. The optimal capacitances are selected so as to resonate with field inductances for the short-circuited armature. The experiments to suppress the 5th and 7th harmonics using the synchronous machine are successful.