gebhart/patrepeval huggingface dataset:
Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation (2000)

Cancer-causing mutations often arise from gross chromosomal rearrangements (GCRs) such as translocations, which involve genetic exchange between nonhomologous chromosomes. Here we show that murine Brca2 has an essential function in suppressing GCR formation after chromosome breakage. Cells that harbor truncated Brca2 spontaneously incur GCRs and genomic DNA breaks during division. They exhibit hypersensitivity to DNA damage by interstrand cross-linkers, which even at low doses trigger aberrant genetic exchange between nonhomologous chromosomes. Therefore, genetic instability in Brca2-deficient cells results from the mutagenic processing of spontaneous or induced DNA damage into gross chromosomal rearrangements, providing a mechanistic basis for cancer predisposition.
Selective Formation of a Symmetric Sc<sub>3</sub>N@C<sub>78</sub> Bisadduct:  Adduct Docking Controlled by an Internal Trimetallic Nitride Cluster (2008)

In this paper we report a regioselective Bingel−Hirsch reaction of Sc3N@C78 yielding a single mono- and a dominate bis-ethyl malonate derivative for the first time. The Cs-symmetric monoadduct 1 and C2v-symmetric bisadduct 2 were isolated by HPLC and characterized by MS, UV−vis, and NMR spectroscopy. The symmetric bisadduct 2 clearly demonstrate the remarkable regioselectivity control exerted by the encapsulated Sc3N cluster. We have employed a LUMO electron density surface computational approach to predict multiadduct docking sites on the ellipsoidal fullerene cage surface.
Four zona pellucida glycoproteins are expressed in the human (2004)

Four ZP genes are expressed in human oocytes (ZP1, ZP2, ZP3 and ZPB) and preliminary data show that the four corresponding ZP proteins are present in the human ZP. Therefore, this is a fundamental difference with the mouse model
Suitability of BlackBox dataset for style analysis in detection of source code plagiarism (2017)

Plagiarism is one of the most common problem that has been increasing in the field of higher education. Many research papers have highlighted the issue of plagiarism in context to its detection and source that is often obtained from the text books and online sources, there is a variety of easy ways for students to copy others' work. Coding style can be used to detect source code plagiarism because it relates to programmer personality but does not affect the logic of a program, thus offering a way to differentiate between different code authors. The immediate objective of this paper is to identify whether a data set consisting of student programming assignments is rich enough to apply coding style metrics on in order to detect similarities between code sequences, and we use the BlackBox data set as a case study.
Formation of guaiacol in chocolate milk by the psychrotrophic bacterium Rahnella aquatilis (2001)

This is the first report that the coliform Rah. aquatilis can produce guaiacol in refrigerated chocolate milk products.
The brain in infantile autism (1994)

Infantile autism is a neurologic disorder of social, cognitive, and language development. Earlier MRI studies found hypoplasia of posterior vermal lobules VI and VII and cerebellar hemispheres in the majority of autistic patients, and recent autopsy analyses find severe Purkinje neuron loss in the posterior vermis (lobules VI and VII and VIII to X) and hemispheres. A second type of cerebellar pathology in infantile autism was recently found: hyperplasia (excessive enlargement) of posterior vermal lobules VI and VII. If the autistic samples in some MRI studies that did not detect cerebellar hypoplasia were actually composed of both the hypoplasia and hyperplasia subtypes, then the autistic mean size reported in such studies would have appeared to be near the normal mean size only because it would be the sum of the two opposite subtypes. To test this possibility, we statistically reanalyzed previously published vermal area measures of 78 autistic patients from four separate studies. The results revealed that the autistic patient samples from these four studies were indeed composed of both the hypoplasia subtype (87%, 92%, 89%, and 84% of patients) and the hyperplasia subtype (13%, 8%, 11%, and 16% of patients). Cerebellar abnormalities have been found in 15 autopsy and quantitative MRI reports from nine laboratories involving a total of 226 autistic cases. Autism may be one of the first developmental neuropsychiatric disorders for which substantial concordance exists among several independent microscopic and macroscopic studies as to the location and type of neuroanatomic maldevelopment. Onset might be as early as the second trimester. Discovery of the etiologies underlying cerebellar maldevelopment may be the key to uncovering some of the causes of infantile autism.
Protective Effects of Epigallocatechin Gallate after UV Irradiation in Cultured Human Retinal Pigment Epithelial Cells (2007)

The administration of EGCG increased the cell count and the cell activity after UV irradiation in cultured human retinal pigment epithelial cells; this suggests that EGCG provided protection against UV damage in cultured human retinal pigmented epithelial cells.
The Effects of Hyponatraemia and Subarachnoid Haemorrhage on the Cerebral Vasomotor Responses of the Rabbit (1991)

Impairment of cerebral autoregulation and development of hyponatraemia are both implicated in the pathogenesis of delayed cerebral ischaemia and infarction following subarachnoid haemorrhage (SAH) but the pathophysiology and interactions involved are not fully understood. We have studied the effects of hyponatraemia and SAH on the cerebral vasomotor responses of the rabbit. Cerebrovascular reactivity to hypercapnia and cerebral autoregulation to trimetaphan-induced hypotension were determined in normal and hyponatraemic rabbits before and 6 days after experimental SAH produced by two intracisternal injections of autologous blood. Hyponatraemia (mean plasma sodium of 119 mM) was induced gradually over 48 h by administration of Desmopressin and intraperitoneal 5% dextrose. Sham animals received normal saline. The cerebrovascular reactivity (% change +/- SD in cortical CBF/mm Hg PaCO2, measured by hydrogen clearance) of hyponatraemic (4.8 +/- 3.0%) and SAH (1.3 +/- 2.0%) animals was significantly less (p less than 0.05) than control (11.6 +/- 4.0%) and sham (8 +/- 2.0%) animals, whereas the reactivity of hyponatraemic-SAH animals was preserved (9.8 +/- 6.0%). Hyponatraemia and SAH alone each significantly impaired CBF autoregulation but their combined effects were not additive. Systemic hyponatraemia impairs normal cerebral vasomotor responses but does not augment the effects of experimental SAH in the rabbit.
Pharmacokinetics of physostigmine in man following a single application of a transdermal system. (1995)

1. The pharmacokinetics of physostigmine were investigated in a three-way cross-over design in six healthy, male volunteers comparing a physostigmine transdermal system (PTS), an oral solution and an i.v. infusion. 2. A single application of the patch over 24 h produced detectable plasma drug concentrations after a mean lag-time of 4 h. Thereafter, the drug was absorbed continuously from the PTS and putative therapeutic plasma concentrations were measured over approximately 18 h. 3. A mean absolute bioavailability of 36% was determined for the transdermal system and 3% for the oral solution. In comparison with the oral solution, interindividual variability of pharmacokinetics was less with the PTS. 4. The mean amount of physostigmine released from the transdermal system after 24 h was 5.7 mg. Because of extensive metabolism, only 2.2 mg of physostigmine were detected systemically. 5. After removing the PTS, the mean apparent half-life of elimination was 4.9 h, compared with 0.5 h for the i.v. infusion. This indicates continued drug absorption from a skin depot. 6. Physostigmine was well tolerated by the volunteers. With the PTS, a mild erythema was observed at the area of application, disappearing within a few hours.
Studies on protein‐DNA interactions using the resonant recognition model (1992)

The structural features of protein-DNA interactions have been evaluated using a new information theory algorithm for the analysis of protein structure/function dependence: the so-called resonant recognition model. The physicochemical basis of this analysis was firstly validated with the trp-repressor-operator interaction as a well-defined example. The amino acid and structural features predicted by these procedures to be crucial for repressor-operator interaction were found to be clustered around the known three-dimensional structure of the active site of the trp repressor. Similar methods of analysis have been extended to the less-well-defined example of the Ha-ras p21 protein family. The results of this analysis have indicated two distinct interactive regions in p21, one associated with the guanine-nucleotide-binding site, whilst the second is proposed to be associated with a binding site for an activator protein. These studies indicate that the p21 protein, besides the ability to function as a plasma-membrane-associated guanine-nucleotide-binding regulatory protein and bind free guanine nucleotides in the cytoplasm, has the structural ability to bind guanine incorporated in DNA. Thus, p21-related proteins may have the potential to function as an DNA-binding and regulating protein with the mode of upstream DNA binding closely related to their oncogenic function.
Exercise Pulmonary Hypertension in Asymptomatic Degenerative Mitral Regurgitation (2010)

Exercise PHT is frequent in patients with asymptomatic degenerative mitral regurgitation. Exercise mitral regurgitation severity is a strong independent predictor of both exercise SPAP and exercise PHT. Exercise PHT is associated with markedly low 2-year symptom-free survival, emphasizing the use of exercise echocardiography. An exercise SPAP >56 mm Hg accurately predicts the occurrence of symptoms.
Grammatical error prediction (2021)

In this thesis, we investigate methods for automatic detection, and to some extent correction, of grammatical errors. The evaluation is based on manual error annotation in the Cambridge Learner Corpus (CLC), and automatic or semi-automatic annotation of error corpora is one possible application, but the methods are also applicable in other settings, for instance to give learners feedback on their writing or in a proofreading tool used to prepare texts for publication. Apart from the CLC, we use the British National Corpus (BNC) to get a better model of correct usage, WordNet for semantic relations, other machine-readable dictionaries for orthography/morphology, and the Robust Accurate Statistical Parsing (RASP) system to parse both the CLC and the BNC and thereby identify syntactic relations within the sentence. An ancillary outcome of this is a syntactically annotated version of the BNC, which we have made publicly available. We present a tool called GenERRate, which can be used to introduce errors into a corpus of correct text, and evaluate to what extent the resulting synthetic error corpus can complement or replace a real error corpus. Different methods for detection and correction are investigated, including: sentence-level binary classification based on machine learning over n-grams of words, n-grams of part-of-speech tags and grammatical relations; automatic identification of features which are highly indicative of individual errors; and development of classifiers aimed more specifically at given error types, for instance concord errors based on syntactic structure and collocation errors based on co-occurrence statistics from the BNC, using clustering to deal with data sparseness. We show that such techniques can detect, and sometimes even correct, at least certain error types as well as or better than human annotators. We finally present an annotation experiment in which a human annotator corrects and supplements the automatic annotation, which confirms the high detection/correction accuracy of our system and furthermore shows that such a hybrid set-up gives higher-quality annotation with considerably less time and effort expended compared to fully manual annotation.
Methylocella silvestris sp. nov., a novel methanotroph isolated from an acidic forest cambisol (2003)

Two strains of Gram-negative, aerobic, non-pigmented, non-motile, rod-shaped, methane-oxidizing bacteria were isolated from an acidic forest cambisol near Marburg, Germany, and were designated as strains BL2(T) and A1. These bacteria were morphologically and phenotypically similar to Methylocella palustris K(T). The cells possess a highly specific bipolar appearance. They lack the intracytoplasmic membranes common to all methane-oxidizing bacteria except Methylocella, but contain a vesicular membrane system connected to the cytoplasmic membrane. A soluble methane monooxygenase was present, but no particulate methane monooxygenase could be detected. These bacteria utilize the serine pathway for carbon assimilation. Strains BL2(T) and A1 are moderately acidophilic, mesophilic organisms capable of growth at pH values between 4.5 and 7 (with an optimum at pH 5.5) and at temperatures between 4 and 30 degrees C. Compared with Methylocella palustris K(T), these strains have greater tolerance of cold temperatures, dissolved salts and methanol. On the basis of 16S rRNA gene sequence identity, of species with validly published names, strain BL2(T) is most closely related to Methylocella palustris K(T) (97.3 % identity), Beijerinckia indica subsp. indica ATCC 9039(T) (97.1 %) and Methylocapsa acidiphila B2(T) (96.2 %). The DNA G+C content is 60 mol% and the major phospholipid fatty acid is 18 : 1omega7. Strain BL2(T) showed only 21-22 % DNA-DNA hybridization with Methylocella palustris K(T). The data therefore suggest that strains BL2(T) and A1 represent a novel species of Methylocella; the name Methylocella silvestris sp. nov. is proposed, with strain BL2(T) (=DSM 15510(T)=NCIMB 13906(T)) as the type strain.
Full polarimetric beam‐forming algorithm for through‐the‐wall radar imaging (2011)

Development of an imaging algorithm that accurately models the wave propagation physical process has become an important topic in through‐the‐wall radar imaging (TWRI). In this paper, a full polarimetric beam‐forming algorithm for through‐the‐wall radar imaging for a general multilayer wall case is presented and applied to various 2D and 3D simulated and measured scenarios. Polarimetric TWRI not only enhances the target characterization but also mitigates the wall ringing effect in cross polarizations. The far field layered medium Green's function is incorporated in the proposed TWRI algorithm for the quad‐polarization of the target returns, namely, VV, HV, VH and HH. Due to the incorporation of the layered medium Green's function, the imaging algorithm not only takes into account the wall reflection, bending, and delay effects but also accounts for the complex scattering mechanism due to the presence of the wall. Numerical and experimental results show that the proposed full polarimetric beam former can provide high quality focused images in various wall‐target scenarios, in particular, when the technique is combined with a wall parameter estimation technique.
Hyperspectral image super-resolution: a hybrid color mapping approach (2016)

NASA has been planning a hyperspectral infrared imager mission which will provide global coverage using a hyperspectral imager with 60-m resolution. In some practical applications, such as special crop monitoring or mineral mapping, 60-m resolution may still be too coarse. There have been many pansharpening algorithms for hyperspectral images by fusing high-resolution (HR) panchromatic or multispectral images with low-resolution (LR) hyperspectral images. We propose an approach to generating HR hyperspectral images by fusing high spatial resolution color images with low spatial resolution hyperspectral images. The idea is called hybrid color mapping (HCM) and involves a mapping between a high spatial resolution color image and a low spatial resolution hyperspectral image. Several variants of the color mapping idea, including global, local, and hybrid, are proposed and investigated. It was found that the local HCM yielded the best performance. Comparison of the local HCM with >10 state-of-the-art algorithms using five performance metrics has been carried out using actual images from the air force and NASA. Although our HCM method does not require a point spread function (PSF), our results are comparable to or better than those methods that do require PSF. More importantly, our performance is better than most if not all methods that do not require PSF. After applying our HCM algorithm, not only the visual performance of the hyperspectral image has been significantly improved, but the target classification performance has also been improved. Another advantage of our technique is that it is very efficient and can be easily parallelized. Hence, our algorithm is very suitable for real-time applications.
COVID-19 (2022)

The SARS-CoV-2 pandemic has resulted in serious health problems, with varying risks of infection as new variants emerge around the world. The impacts of the infection extend well beyond the acute phase and demand significant attention toward long-term rehabilitation services. Speech-language pathologists are an important member of the rehabilitation team and are responsible for ensuring patient safety and well-being. In this narrative, we discuss information about the impact of COVID-19 on speech, cognition, and swallowing. We also examine speech-language pathologists’ role in the management and rehabilitation of patients with COVID-19, new methods of service delivery during and after the pandemic, and future challenges in speech-language pathology rehabilitation services resulting from the pandemic. To this end, we have utilized reports, research findings, and guidelines from published literature to introduce the reader to the widespread effects of COVID-19 on patients and professionals in the speech-language pathology community.
The Role of Back Buffer Layers and Absorber Properties for >25% Efficient CdTe Solar Cells (2019)

As the performance of the front interface and the CdTe absorber are improved, minority carrier recombination at the back of the device will limit the photoconversion efficiency. To determine the limits of performance, we have completed simulations to understand the loss mechanisms, the band bending, and the energetics at the interface between the absorber and the back contact buffer layer. In particular, we have explored how the conduction and valence band offsets, the doping levels in the back buffer and CdTe layers, and the back surface recombination velocity affect the device performance. These results provide guidance for the development of back contacts that will help push CdTe device efficiencies to 25% and beyond.
SELF-ASSEMBLED CORE-SHELL POLYMER DIELECTRIC PREPARED BY SOLUTION CASTING PROCESS (2010)

ABSTRACT Giant permittivity at 1 MHz, which slightly changes with temperatures, is observed in a polymer composite. The dielectric spectroscopy demonstrates that the samples are electrically heterogeneous. The microstructure observation and the ingredient analysis evidence they self assemble the conducting cores surrounded by the insulating shells. The giant-dielectric phenomenon is therefore attributed to the percolation effect. The electrically heterogeneous microstructure with effective permittivity values about 10 000 can be fabricated by a simple solution casting process in air. The composite is an attractive option to the currently used printing dielectric and the future flexible electronics. Keywords: High dielectricPolymer composite
CD8+ T Cell Responses during HCV Infection and HCC (2021)

Chronic hepatitis C virus (cHCV) infection is a major global health burden and the leading cause of hepatocellular carcinoma (HCC) in the Western world. The course and outcome of HCV infection is centrally influenced by CD8<sup>+</sup> T cell responses. Indeed, strong virus-specific CD8<sup>+</sup> T cell responses are associated with spontaneous viral clearance while failure of these responses, e.g., caused by viral escape and T cell exhaustion, is associated with the development of chronic infection. Recently, heterogeneity within the exhausted HCV-specific CD8<sup>+</sup> T cells has been observed with implications for immunotherapeutic approaches also for other diseases. In HCC, the presence of tumor-infiltrating and peripheral CD8<sup>+</sup> T cell responses correlates with a favorable prognosis. Thus, tumor-associated and tumor-specific CD8<sup>+</sup> T cells are considered suitable targets for immunotherapeutic strategies. Here, we review the current knowledge of CD8+ T cell responses in chronic HCV infection and HCC and their respective failure with the potential consequences for T cell-associated immunotherapeutic approaches.
Production et niveau d'exploitation des ressources démersales et semi-pélagiques exploitées par la pêche artisanale seychelloise sur le plateau de Mahé (2023)

Entre 1986 et 1990, les débarquements des espèces démersales et semi-pélgiques exploitées par la pêche artisanale seychelloise sur le plateau de Mahé ont varié entre 3 320 et 4 370 t. Les prises des casiers ont régulièrement diminué durant cette période. En revanche, les débarquements des lignes à main, stables entre 1986 et 1989, ont connu une forte augmentation en 1990. Les résultats des campagnes de chalutage et acoustiques réalisées dans les eaux seychelloises ne peuvent être utilisés pour l’évaluation de ces ressources exploitées. La comparaison des productions relatives (production par unité de surface) de pêcheries tropicales en milieu corallien montre que les faibles valeurs de cette production seychelloise résultent d’un effort de pêche faible. Dans un premier temps, une production potentielle (production maximale biologiquement autorisée) de 9 000 t peut être considérée par les décideurs de l’aménagement.
IL-8 as a urinary biomarker for the detection of bladder cancer (2012)

These results suggest that the measurement of IL-8 in voided urinary samples may have utility for urine-based detection of BCa. These findings need to be confirmed in a larger, prospective cohort.
Investigation of upscaled rock-fluid interaction devised from discrete and automated steady-state fractional flow methods in stratified assemblages (2016)

Multiple methods exist for the steady-state upscaling of fluid-rock interaction from finer scale digital rock physics and laboratory scale coreflooding process. Discrete fractional flow methodologies exist, which are cursory in nature because the a priori in-situ saturation is not a function of the saturation history of the modeled media. Alternatively, automated upscaling methods explicitly follow the fractional flow history of the saturated media in the coreflooding process, preserving the accuracy of fluid trapping and transfer as a function of saturation and time. The purpose of this study is to examine the application of discrete and automated steady-state fractional flow upscaling routines for capillary limit (CL) relative permeability upscaling in stratified whole cores in addition to accounting for simulation run-times to assess process efficiency. Presentation Date: Wednesday, October 19, 2016 Start Time: 8:25:00 AM Location: Lobby D/C Presentation Type: POSTER