gebhart/patrepeval huggingface dataset:
Genistein and Daidzein Stimulate Hyaluronic Acid Production in Transformed Human Keratinocyte Culture and Hairless Mouse Skin (2002)

We examined the effects of the soy isoflavones genistein (Gen) and daidzein (Dai) on the production of hyaluronic acid (HA) in a transformed human keratinocyte culture and in hairless mouse skin following topical application for 2 weeks. Gen and Dai, but not the glycosides thereof, significantly enhanced the production of HA in vitro and in vivo. Histochemistry using an HA-binding protein revealed that topical Gen and estradiol raised both the density and intensity of HA staining, which was abundant in the murine dermis. It is suggested that Gen and Dai are not released from their respective glycosides in culture or murine skin. Moreover, topical Gen and Dai may prevent and improve the cutaneous alterations caused by the loss of HA in skin.
21.1: New Structure of IPS Mode with In‐Cell Retarder for TV Application (2006)

Abstract We have developed a new structure for True wide In‐cell IPS (Twin IPS) panel which consists of a positive C plate in the cell. This positive C plate is made of a UV polymerizable Liquid Crystal on the color filter substrate as a retardation film. TWin IPS of 20.1′ VGA has improved diagonal viewing performance without any additional layer in the cell.
: Leaving Las Vegas . Mike Figgis, Lila Cazes, Annie Stewart. (1996)

Book Review| July 01 1996 Review: Leaving Las Vegas by Mike Figgis, Lila Cazès, Annie Stewart Leaving Las VegasMike FiggisLila CazèsAnnie Stewart Albert Johnson Albert Johnson Search for other works by this author on: This Site PubMed Google Scholar Film Quarterly (1996) 49 (4): 38–40. https://doi.org/10.2307/1213557 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Albert Johnson; Review: Leaving Las Vegas by Mike Figgis, Lila Cazès, Annie Stewart. Film Quarterly 1 July 1996; 49 (4): 38–40. doi: https://doi.org/10.2307/1213557 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentFilm Quarterly Search This content is only available via PDF. Copyright 1996 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
The propeptide Asn1–Tyr126 is the storage form of rat atrial natriuretic factor (1987)

Granules from rat atria were isolated by differential centrifugation and by a 53% (v/v) Percoll gradient after tissue homogenization in 0.25 M-sucrose/50 mM-Na2EDTA. About 40% of the immunoreactive ANF (atrial natriuretic factor) sedimented with the atrial granules during differential centrifugations. On the Percoll gradient, two distinct bands were observed. Cell debris, mitochondria, lysosomes, myofilaments and microsomes were mostly contained in the lightest-density (rho) (1.03-1.07 g/ml) fraction, as demonstrated by electron microscopy and by enzymic markers such as lactate dehydrogenase, monoamine oxidase, cytochrome c reductase, beta-glucuronidase and acid phosphatase. Atrial granules were mostly contained in the denser (rho 1.11-1.15 g/ml) band and were only slightly contaminated by lysosomes, as shown by beta-glucuronidase activity. Analysis of the ANF content in these isolated granules by h.p.l.c., amino acid composition and sequencing demonstrated that it was only the pro-ANF [ANF-(Asn1-Tyr126)-peptide]. The precursor was present in all granules, as demonstrated by immunocytochemistry. Since hormonal propeptides usually undergo intracellular processing, and the matured peptides are subsequently stored in the secretory granules, these results indicate that the processing pathway of ANF may be different from that of other hormonal peptides.
Scintillation reduction in multi-Gaussian Schell-model beams propagating in atmospheric turbulence (2014)

The recently introduced class of Multi-Gaussian Schell-model [MGSM] beams is investigated via simulations and experiments with regards to its intensity fluctuations on propagation in atmospheric turbulence. The results indicate that the scintillation index of the MGSM beam is reduced for high values of the summation index, in agreement with previous theoretical results.
Modeling and simulation of e-mail social networks: A new stochastic agent-based approach (2008)

Understanding how the structure of a network evolves over time is one of the most interesting and complex topics in the field of social networks. In our attempt to model the dynamics of such systems, we explore an agent-based approach to model growth of email-based social networks, in which individuals establish, maintain and allow atrophy of links through contact-lists and e-mails. The model is based on the idea of common neighbors, but also on a detailed specialization of the classical preferential attachment theory, thus capturing a deeper understanding of the topology of inter-node connections. In our event-based simulation that schedules the agents' actions over time, the proposed model is amenable to significant efficiency improvements through an application of the Gillespie stochastic simulation schemes. Computer simulation results are used to validate the model by showing that its unique features endow it with ability to simulate real-world email networks with convincing realism.
Impact of noise related waveforms on long term field leakage current measurements (2011)

Leakage current (LC) monitoring is widely employed in order to investigate electrical surface activity on high voltage (HV) insulators. Long term field monitoring is required in order to obtain an actual view of the phenomena. Therefore any monitoring system is bound to encounter data size problems. A number of solutions have been proposed to address this problem by extracting different values from the measured waveforms as a performance indication. However, a parameter that is fully representative of the waveform is yet to be determined. Hence, measuring and storing of the actual LC waveform is still required on sites for research and monitoring purposes. In addition, field related noise can result to misinterpretation of the actual activity. In this paper, a number of 26089 waveforms, recorded in a 150 kV Substation on four different post insulators that are part of the grid, are investigated. The monitoring period exceeded six years. Different techniques are applied and evaluated on the data set, employing simple numeric criteria and more advanced techniques such as Fourier and Wavelet analysis. Results are presented towards addressing the problems of noise and data size. The study objective is the incorporation of the results in improved leakage current monitoring systems.
Database Replication Using Generalized Snapshot Isolation (2006)

Generalized snapshot isolation extends snapshot isolation as used in Oracle and other databases in a manner suitable for replicated databases. While (conventional) snapshot isolation requires that transactions observe the "latest" snapshot of the database, generalized snapshot isolation allows the use of "older" snapshots, facilitating a replicated implementation. We show that many of the desirable properties of snapshot isolation remain. In particular, read-only transactions never block or abort and they do not cause update transactions to block or abort. Moreover, under certain assumptions on the transaction workload the execution is serializable. An implementation of generalized snapshot isolation can choose which past snapshot it uses. An interesting choice for a replicated database is prefix-consistent snapshot isolation, in which the snapshot contains at least all the writes of locally committed transactions. We present two implementations of prefix-consistent snapshot isolation. We conclude with an analytical performance model of one implementation, demonstrating the benefits, in particular reduced latency for read-only transactions, and showing that the potential downsides, in particular change in abort rate of update transactions, are limited.
Amelogenin–chitosan matrix for human enamel regrowth: effects of viscosity and supersaturation degree (2014)

We recently reported an amelogenin-chitosan (CS-AMEL) hydrogel as a promising biomimetic material for future in situ human enamel regrowth. To further optimize the necessary conditions for clinical applicability of CS-AMEL hydrogel, herein we studied the effects of viscosity and supersaturation degree on the size and orientation of synthetic crystals by means of scanning electron microscopy (SEM) and X-ray diffraction (XRD). Raising the hydrogel viscosity by increasing chitosan concentration from 1% to 2% (w/v) improved the orientation of the crystals, while a higher supersaturation (σ(HAp) >10.06, [Ca(2+)] >5 mM) resulted in the formation of random crystals with larger sizes and irregular structures. We conclude that optimal conditions to produce organized enamel-like crystals in a CS-AMEL hydrogel are: 2% (w/v) chitosan, 2.5 mM calcium, and 1.5 mM phosphate (degree of supersaturation = 8.23) and 200 µg/ml of amelogenin.
Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate. (1988)

Denaturation of DNA photolyase (deoxyribodipyrimidine photolyase, EC 4.1.99.3) from Escherichia coli with guanidine hydrochloride or acidification to pH 2 released, in addition to FAD, a chromophore with the spectral and chromatographic properties of a reduced pterin. Treatment of the enzyme with iodine prior to acidification converted the chromophore to a stable, oxidized derivative, which was resolved by HPLC into four species with identical spectral properties. The same species, in the same distribution, were obtained from the yeast enzyme. The material isolated from the iodine-oxidized enzyme was shown to be a pterin by conversion to pterin-6-carboxylic acid with alkaline permanganate and was found to release glutamate upon acid hydrolysis. The presence of 10-formylfolate in the isolated, oxidized chromophore was demonstrated by absorption and fluorescence spectroscopy and by deformylation and conversion to folic acid. Analysis of the distribution of polyglutamates revealed that the four species identified by HPLC corresponded to the tri-, tetra-, penta-, and hexaglutamate derivatives of 10-formylfolate. The results were consistent with gamma linkages in the triglutamate derivative with additional glutamates linked via the alpha-carboxyl group of the preceding residue. Treatment with rat plasma hydrolase produced the monoglutamate derivative of 10-formylfolate. The native, enzyme-bound form of the folate cofactor was identified as 5,10-methenyltetrahydrofolylpolyglutamate by effecting release and isolation at low pH to protect the 5,10-methenyl bridge and preserve the reduced pyrazine ring structure.
Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro (2000)

Dendritic cells (DCs) genetically modified to continually express and present antigens may be potent physiologic adjuvants for induction of prophylactic or therapeutic immunity. We have previously shown that an env and nef deleted HIV-1 vector (HIV-1 delta EN) pseudotyped with VSV-G transduced monocyte-derived macrophages as well as CD34(+) precursors of DCs. Here we extended these findings with HIV-1 delta EN to highly differentiated human DCs derived in culture from circulating monocytes (DCs). In addition, a new vector derived from HIV-1 delta EN but further deleted in its remaining accessory genes vif, vpr, and vpu (HIV-1 delta EN V(3)) was also tested. Both vectors efficiently transduced DCs. Transduction of DCs did not significantly alter their viability or their immunophenotype when compared with untransduced DCs. Furthermore, the phagocytic potential of immature DCs, as well as their ability to differentiate into mature DCs capable of stimulating T-cell proliferation, was not affected. Finally, DCs transduced by the HIV-1 delta EN vector were able to elicit a primary antiviral cytotoxic T-cell response in autologous CD8 T cells. These results suggest that HIV-1-based vectors expressing viral antigens may be useful for in vivo active immunization as well as ex vivo priming of cytotoxic T cells for adoptive T-cell therapy. (Blood. 2000;96:1327-1333)
Two Efficient Hashing Schemes for High-Dimensional Furthest Neighbor Search (2017)

The <inline-formula><tex-math notation="LaTeX">$c$</tex-math></inline-formula> -Approximate Furthest Neighbor ( <inline-formula><tex-math notation="LaTeX">$c$</tex-math></inline-formula> -AFN) search is a fundamental problem in many applications. However, existing hashing schemes for <inline-formula><tex-math notation="LaTeX">$c$ </tex-math></inline-formula> -AFN search are designed for internal memory. The old techniques for external memory, such as furthest point Voronoi diagram and the tree-based methods, are only suitable for the low-dimensional case. In this paper, we introduce a novel concept of the Reverse Locality-Sensitive Hashing (RLSH) family which is directly designed for <inline-formula> <tex-math notation="LaTeX">$c$</tex-math></inline-formula> -AFN search. Accordingly, we propose a new reverse query-aware LSH function, which is a random projection coupled with query-aware interval identification. Based on the reverse query-aware LSH functions, we introduce a novel Reverse Query-Aware LSH scheme named RQALSH for high-dimensional <inline-formula> <tex-math notation="LaTeX">$c$</tex-math></inline-formula> -AFN search over external memory. Our theoretical studies show that RQALSH enjoys a guarantee on query quality. In addition, in order to further speed up RQALSH, we propose a heuristic variant named RQALSH <inline-formula><tex-math notation="LaTeX">$^*$</tex-math></inline-formula> which applies a data-dependent objects selection to largely reduce the number of data objects. In the experiment, we compare with two state-of-the-art hashing schemes QDAFN and DrusillaSelect which have been adapted for external memory. Extensive experiments on four real datasets show that our proposed RQALSH and RQALSH <inline-formula><tex-math notation="LaTeX"> $^*$</tex-math></inline-formula> schemes significantly outperform these two methods.
Query Language for Enterprise Data Integration in SaaS Environment (2008)

In present, companies tend to construct high-quality information systems faster and cheaper in the field of enterprise information systems to respond to rapid change of business environment, using general business application packages or services, avoiding scratch development as much as they can. Plus, they promote to standardize the system used in each company which belongs to the same holdings, using method of shared service and SaaS (Software as a Service). Thus, application environment appears that any database has the same database schema along with penetration and popularization of general business application packages and services. In this paper, we propose the query language which enables to select target databases dynamically in response to tuples condition inside each database and the result of logical operations for multidatabases, and which enables to integrate data of multidatabase by expanding the existing multidatabase query language, MSQL. Keyword Data Integration,Query Language,Multidatabase,SaaS 1. まえがき 現在,企業は会社法・金融商品取引法による内部統 制の法制化,企業間の買収・合併,及び製品ライフサ イクルの短縮化等による事業環境の急激な変化に直面 している. それに伴い,企業の情報システム構築の現場では, 可能なかぎり手作りによるシステム構築は避け,汎用 的な業務アプリケーション・パッケージソフト(以下, パッケージと省略)を利用して,手作りによる自由度の 高さは犠牲にしながらも品質の高いシステムを早く・ 安く構築する傾向が強まっている .また,最近ではパッ ケージの発展形として,インターネットを通じて情報 システム業者が保有する業務アプリケーション機能を サービスとして利用する形態(以下,SaaS と記述)が生 まれ,大きく発展し始めている. また,単一企業のユーザによる業務改革・改善・効 率化を超えた動きも加速しており,企業グループ全体 での業務の最適化,及びサプライチェーン全体を巻き 込んだ業務の最適化・連携が進んでいる.シェアード サービス・センタはその典型的な例であり,グループ 内の複数企業の会計・人事等の業務機能を1つの会社 に集約し,また外部企業からも業務を請け負うことで 業務全体の費用対効果を向上させている. こうした状況の中で,データベースの独立性を保ち ながら複数企業が同一のシステムを共同利用する方式 が出始めており,以下の2点の要件が顕在化してきて いる. (1) データベースをまたがった問合せを行う. (2) 問合せ対象のデータベースが固定的ではなく変化 する. 例えば,連結会計処理の際に,自社の持つ株式の保 有比率に応じて連結処理を行う子会社を動的に選択し, その企業のデータベースから会計データを抽出すると いう問合せが上記要件に相当する. 本研究では,データベースをまたがった問合せが可 能な MSQL を拡張し,問合せ対象となるデータベース を動的に選択してデータ操作が可能な問合せ言語を提
2-Methoxyestradiol Inhibits the Anaphase-Promoting Complex and Protein Translation in Human Breast Cancer Cells (2007)

2-methoxyestradiol (2ME2), an estradiol metabolite with antiproliferative and antiangiogenic activities, is in phase I/II clinical trials for breast cancer. 2ME2 inhibits microtubule polymerization and causes cells to arrest in G2-M. The purpose of this study was to further elucidate the molecular mechanism of 2ME2. MDA-MB-435 breast cancer cells were treated with 2ME2 (2 micromol/L) or vehicle alone. RNA was extracted and genomic profiling was done using 22k Agilent microarrays. Expression Analysis Systematic Explorer was used to determine enrichment of Gene Ontology categories. Protein isolates were subjected to Western blot analysis. Protein synthesis was measured with a [35S]methionine pulse assay. An MDA-MB-435 cell line with two beta-tubulin mutations (2ME2R) was used to determine whether novel mechanisms were tubulin-dependent. Gene Ontology categories enriched include genes that regulate the mitotic spindle assembly checkpoint, apoptosis, and the cytosolic ribosome. The target of the mitotic spindle assembly checkpoint is the anaphase-promoting complex (APC). APC inhibition was confirmed by measuring protein levels of its targets securin and cyclin B1, which were increased in 2ME2-treated cells. Because gene expression in the cytosolic ribosome category was decreased, we evaluated whether 2ME2 decreases protein translation. This was confirmed with a pulse assay, which showed decreased isotope incorporation in 2ME2-treated cells, which was maintained in the tubulin-resistant 2ME2R cells. APC inhibition was not maintained in 2ME2R cells. 2ME2 induces tubulin-dependent cell cycle arrest through regulation of genes involved in the mitotic spindle assembly checkpoint, which results in inhibition of the APC and tubulin-independent inhibition of protein translation.
Reflective point-dif fraction microscopic interferometer with long-term stability (Invited Paper) (2011)

An on-axis phase-shifting reflective point-diffraction microscopic interferometer for quantitative phase microscopy based on Michelson architecture is proposed. A cube beamsplitter splits the object wave spectrum into two copies within two arms. Reference wave is rebuilt in one arm by low-pass filtering on the object wave frequency spectrum with a pinhole-mask mirror, and interferes with the object wave from the other arm. Polarization phase-shifting is performed and phase imaging on microscale specimens is implemented. The experimental results demonstrate that the proposed scheme has the advantage of long-term stability due to its quasi common-path geometry with full use of laser energy.
"Sandwich"-type immunoassay of carcinoembryonic antigen in patients receiving murine monoclonal antibodies for diagnosis and therapy. (1988)

Measurements of carcinoembryonic antigen (CEA) in blood increased dramatically in some patients who were receiving injections of monoclonal antibody. CEA titers were measured with a monoclonal antibody-based double-determinant enzyme immunoassay in which untreated plasma specimens were diluted with an equal volume of buffer containing mouse serum. Increasing CEA titers were accompanied by the appearance and coincident increase in titers of human antibody against mouse Ig (HAMA). Adsorption of these sera with solid-phase anti-human IgG or Protein A restored antigen titers to pretreatment values; evidently the serum factor eliciting false-positive CEA titers was most probably HAMA. Neither addition of undiluted mouse serum to the assay mixture nor pretreatment by heating plasma specimens to 70 degrees C effectively abolished HAMA interference. By contrast, protein precipitation with polyethylene glycol (130 g/L) or heating plasma samples to 90 degrees C eliminated false-positive titers caused by HAMA, but did not reduce authentic CEA titers.
Ultrahigh-Speed TV Commercial Detection, Extraction, and Matching (2013)

We describe a system based on exact-duplicate matching for detecting and localizing TV commercials in a video stream, clustering the exact duplicates, and detecting duplicate exact-duplicate clusters across video streams. A two-stage temporal recurrence hashing algorithm is used for the detection, localization, and clustering. The algorithm is fully unsupervised, generic, and ultrahigh speed. Another algorithm is used to integrate the video and audio streams to achieve higher performance extraction. Its sequence- and frame-level accuracies in testing were respectively 98.1% and 97.4%. A third algorithm uses a new bag-of-fingerprints model to detect duplicate exact-duplicate clusters across multiple streams. It is robust against decoding errors. Its contributions include: 1) fully unsupervised detection, extraction, and matching of exact duplicates; 2) more generic commercial detection than with the knowledge-based techniques; 3) ultrahigh-speed processing, which detected the TV commercials from a one-month video stream in less than 42 minutes, which is more than ten times faster than with state-of-the-art algorithms; and 4) more generic operation in terms of signal input, the performance of which is consistent between video and audio streams. Testing using a video database containing a ten-hour, a one-month, and a five-year video stream comprehensively demonstrates the effectiveness and efficiency of this system.
Differential static analysis (2010)

It is widely believed that program analysis can be more closely targeted to the needs of programmers if the program is accompanied by further redundant documentation. This may include regression test suites, API protocol usage, and code contracts. To this should be added the largest and most redundant text of all: the previous version of the same program. It is the differences between successive versions of a legacy program already in use which occupy most of a programmer's time. Although differential analysis in the form of equivalence checking has been quite successful for hardware designs, it has not received as much attention in the static program analysis community.
Ozone Impacts of Natural Gas Development in the Haynesville Shale (2010)

The Haynesville Shale is a subsurface rock formation located beneath the Northeast Texas/Northwest Louisiana border near Shreveport. This formation is estimated to contain very large recoverable reserves of natural gas, and during the two years since the drilling of the first highly productive wells in 2008, has been the focus of intensive leasing and exploration activity. The development of natural gas resources within the Haynesville Shale is likely to be economically important but may also generate significant emissions of ozone precursors. Using well production data from state regulatory agencies and a review of the available literature, projections of future year Haynesville Shale natural gas production were derived for 2009-2020 for three scenarios corresponding to limited, moderate, and aggressive development. These production estimates were then used to develop an emission inventory for each of the three scenarios. Photochemical modeling of the year 2012 showed increases in 2012 8-h ozone design values of up to 5 ppb within Northeast Texas and Northwest Louisiana resulting from development in the Haynesville Shale. Ozone increases due to Haynesville Shale emissions can affect regions outside Northeast Texas and Northwest Louisiana due to ozone transport. This study evaluates only near-term ozone impacts, but the emission inventory projections indicate that Haynesville emissions may be expected to increase through 2020.