gebhart/patrepeval huggingface dataset:
Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems (2005)

Chemokine receptors, a family of Gi protein-coupled receptors responsible for cell migration, are widely expressed by cells of immune and nervous systems. Activation of receptors on the surface of leukocytes, such as opioid, vasoactive intestinal peptide, or adenosine receptors, often has inhibitory effects on chemokine receptors by a mechanism termed heterologous desensitization, resulting in suppression of immune responses. Conversely, activation of chemokine receptors also induces heterologous desensitization of mu-opioid receptors (MOR), a class of key analgesic receptors on neurons. Furthermore, prior exposure of neuronal cells to chemokine treatment enhances the sensitivity of transient receptor potential vanilloid 1 (TRPV1), a heat- and ligand-gated calcium channel, which is critical for sensing of pain. Consequently, during inflammation, activation of chemokine receptors on neurons contributes to hyperalgesia by inhibiting MOR and concomitantly sensitizing TRPV1 via Gi protein-mediated signaling pathways. These observations suggest that the crosstalk between chemokine receptors and neuropeptide membrane receptors serves as a bridge between the immune and nervous systems.
J. R. Campbell (1981)

Fundamental to the successful programs and activities of the American Dairy Science Association over the past 75 yr have been the cooperation and contributions of hundreds of dedicated scientists, teachers, extension workers, representatives of government and industry, and students.We again have called on a number representing these groups, this time to author this special issue of the Journal of Dairy Science commemorating our Diamond Jubilee Anniversary.This 75th year of our Association is of more than routine historical significance.It affords us the opportunity to reflect on the past and, more importantly, also to look ahead.The search for a simple formula of what the future holds for our Association and the dairy industry can best begin by asking the experts to review what has happened and project into the future.This has been done through the cooperative efforts of some 86 authorities who prepared the articles that comprise this special issue.We asked the authors to devote primary attention to developments of dairy science and the dairy industry during the past 25 years, as those o f JOHN R. CAMPBELL our first 50 years were highlighted in the special 1956 Journal of Dairy Science issue commemorating our Golden Anniversary.Because this special issue constitutes a history of dairy science and the dairy industry during a period of rapid advances in science, technology, and education, it is our hope that it will be used widely and be of long-lasting value.Dairy scientists who contributed to research, teaching, public service, and other activities and programs related to the dairy industry over the years -those who generated most of the history recorded h e r e -are too numerous to name and impossible to repay.But we are especially indebted to the authors of this issue and to the three coordinating editors, A. S. Achacoso, general topics; H. D. Hafs, dairy production papers; and R. T. Marshall, dairy foods papers.We are also grateful to our editor-in-
The Association of CD46, SLAM and CD209 Cellular Receptor Gene SNPs with Variations in Measles Vaccine-Induced Immune Responses: A Replication Study and Examination of Novel Polymorphisms (2011)

Understanding the functional and mechanistic consequences of these genetic polymorphisms on immune response variations could assist in directing new measles and potentially other viral vaccine design, and in better understanding measles immunogenetics.
Autonomous swarm testbed with multiple quadcopters (2014)

A testbed has been developed to validate and trial swarm engineering concepts. The vehicles used in this testbed are commercially available Parrot AR.Drone quadcopters that are controlled through a computer interface connected over a 65Mbps, IEEE 802.11n (Wi-Fi), network. The testbed architecture is presented with the implementation of a distributed controller, for each vehicle, discussed. The controller relies on a tracking system to provide precise information on the position and orientation of the aerial vehicles within the enclosure. This enables the autonomous and distributed elements of the control scheme to be retained, whilst alleviating the drones of the control algorithm's computational load. The testbed is used to control 3 drones effectively, where the control, communication and tracking systems are scalable to at least 12 drones. The paper also introduces the application of swarm engineering in remote visual inspection, with multiple airborne platforms visually inspecting a target by completing coverage bands before transitioning to another height. A kinematic field enables the drones to follow this path autonomously with the field being asymmetrically modified as a result of drone interactions. This modification of the field for a single drone is shown to prevent vehicle collisions by enabling queuing behind the leader. Using a swarm of 3 quadcopters, the coverage time for a target can be reduced by around 60% when compared with a solitary drone. Finally the three-dimensional model of a target that is generated from drone footage is presented; this surface-meshed model is constructed in post-processing, through photogrammetric analysis of the collected images.
The effect of hindered amine light stabilizers on the photooxidative stability of high‐density polyethylene (1989)

Abstract The photoprotective effectiveness of various polymeric and nonpolymeric hindered amine light stabilizers (HALS) was determined by exposing samples of high‐density polyethylene (HDPE) containing these additives to ultraviolet (UV) light and measuring the resultant oxygen uptake characteristics. Values of the initial quantum yield for oxygen uptake calculated for these formulations indicate that the higher molecular weight HALS compounds are less effective photostabilizers than the nonpolymeric HALS, and this is partly attributable to their decreased mobility in the polymer matrix. It was further found that the addition of an ultraviolet absorber (UVA) to a formulation containing a polymeric HALS compound enhances its photostability, although this phenomenon may be partly due to synergism between the UVA and the antioxidant, the latter having been added as part of the base stabilization. The antagonism which exists between certain sulfur‐containing antioxidants and HALS compounds was also investigated and it was found that the lower molecular weight sulfur‐containing antioxidants exhibit the greatest degree of antagonism. The results confirm that the mobility in the polymer matrix of the stabilizer system can serve as an explanation of its effectiveness. The article provides evidence that the technique of oxygen uptake monitoring is a sensitive and rapid method of assessment of polymer photostability in the presence of stabilizer systems.
Bis(phenazine-1-carboxamides):  Structure−Activity Relationships for a New Class of Dual Topoisomerase I/II-Directed Anticancer Drugs (2000)

Ring-substituted bis(phenazine-1-carboxamides), linked by a -(CH(2))(3)NMe(CH(2))(3)- chain, were prepared from the corresponding substituted phenazine-1-carboxylic acids by reaction of the intermediate imidazolides with bis(3-aminopropyl)methylamine. The compounds were evaluated for growth inhibitory activity in a panel of tumor cell lines, including P388 leukemia, Lewis lung carcinoma, and wild-type (JL(C)) and mutant (JL(A) and JL(D)) forms of human Jurkat leukemia. The latter mutant lines are resistant to topoisomerase (topo) II targeted agents because of lower levels of the enzyme. Analogues with small, lipophilic substituents (e.g., Me, Cl) at the 9-position were the most potent inhibitors, superior to the corresponding dimeric bis(acridine-4-carboxamides) (bis-DACA analogues). Several of the compounds were preferentially (up to 2-fold) more cytotoxic toward the mutant Jurkat lines than the wild-type. To test whether this selectivity was related to topoisomerase action, the most potent of the compounds (9-methyl) was evaluated in a cell-free system. It poisoned topo I at drug concentrations of 0.25 and 0.5 microM and inhibited the catalytic activity of both topo I and topo II at concentrations of 1 and 5 microM, respectively. Results from the NCI human tumor cell line panel showed the compounds had preferential activity toward colon tumor lines (on average 9.5-fold more active in the HT29 line than in the cell line panel as a whole). Several analogues produced significant growth delays in the relatively refractory subcutaneous colon 38 tumor model in vivo. In particular, the 9-methyl compound was substantially more potent in this tumor model than the clinical dual topo I/II poison DACA (total dose 90 versus 400 mg/kg) with comparable activity. The bis(phenazine-1-carboxamides) are a new and interesting class of dual topo I/II-directed anticancer drugs.
Selection of mutant Chinese hamster ovary cells altered glycoproteins by means of tritiated fucose suicide. (1981)

Mutant Chinese hamster ovary cells altered in glycoproteins have been isolated by selecting for ability to survive exposure to [6-3H]fucose. Mutagenized wild-type cells were permitted to incorporate [3H]fucose to approximately 1 cpm of trichloroacetic acid-insoluble radioactivity per cell and then frozen for several days to accumulate radiation damage. The overall viability of the population was reduced by 5- to 50-fold. Four consecutive selection cycles were carried out. The surviving cells were screened by replica plating-fluorography for clones showing decreased incorporation of fucose into trichloroacetic acid-insoluble macromolecules. Considerable enrichment for cells deficient in fucose uptake or incorporation into proteins (or both) was found in populations surviving the later selection cycles. Two mutant clones isolated after the fourth selection cycle had the same doubling time as the wild type, but contained only 30 to 40% as much fucose bound to proteins as the wild type. Sialic acid contents of the mutants and the wild type were similar. The mutants differed quantitatively and qualitatively from the wild type and from each other with respect to total glycoprotein profiles as visualized by sodium dodecyl sulfate gel electrophoresis. Differences were also found in resistances to cytotoxicity of lectins such as concanavalin A and wheat germ agglutinin.
Probing Allosteric Binding Sites of the Maize Endosperm ADP-Glucose Pyrophosphorylase   (2009)

Maize (Zea mays) endosperm ADP-glucose pyrophosphorylase (AGPase) is a highly regulated enzyme that catalyzes the rate-limiting step in starch biosynthesis. Although the structure of the heterotetrameric maize endosperm AGPase remains unsolved, structures of a nonnative, low-activity form of the potato tuber (Solanum tuberosum) AGPase (small subunit homotetramer) reported previously by others revealed that several sulfate ions bind to each enzyme. These sites are also believed to interact with allosteric regulators such as inorganic phosphate and 3-phosphoglycerate (3-PGA). Several arginine (Arg) side chains contact the bound sulfate ions in the potato structure and likely play important roles in allosteric effector binding. Alanine-scanning mutagenesis was applied to the corresponding Arg residues in both the small and large subunits of maize endosperm AGPase to determine their roles in allosteric regulation and thermal stability. Steady-state kinetic and regulatory parameters were measured for each mutant. All of the Arg mutants examined--in both the small and large subunits--bound 3-PGA more weakly than the wild type (A(50) increased by 3.5- to 20-fold). By contrast, the binding of two other maize AGPase allosteric activators (fructose-6-phosphate and glucose-6-phosphate) did not always mimic the changes observed for 3-PGA. In fact, compared to 3-PGA, fructose-6-phosphate is a more efficient activator in two of the Arg mutants. Phosphate binding was also affected by Arg substitutions. The combined data support a model for the binding interactions associated with 3-PGA in which allosteric activators and inorganic phosphate compete directly.
Principles and Guidelines in Software User Interface Design (2008)

1. Introduction. 2. The User Profile. 3. Conceptual Models. 4. Dialog Styles: Menus. 5. Dialog Styles: Fill-In Forms. 6. Dialog Styles: Question and Answer. 7. Dialog Styles: Command Languages. 8. Dialog Styles: Function Keys. 9. Dialog Styles: Direct Manipulation. 10. Dialog Styles: Natural Language. 11. Dialog Styles: Summary. 12. Input and Output Devices. 13. Organization and Functionality. 14. Screen Layout and Design. 15. Response Time. 16. Error Handling. 17. User Documentation. 18. Summary and Conclusions.
Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma (2017)

The antitumor response after therapeutic vaccination has a limited effect and seems to be related to the presence of T regulatory cells (Treg), which express the immunoregulatory molecules CTLA4 and Foxp3. The blockage of CTLA4 using antibodies has shown an effective antitumor response conducing to the approval of the human anti-CTLA4 antibody ipilimumab by the US Food and Drug Administration. On the other hand, Foxp3 is crucial for Treg development. For this reason, it is an attractive target for cancer treatment. This study aims to evaluate whether combining therapeutic vaccination with CTLA4 or Foxp3 gene silencing enhances the antitumor response. First, the "in vitro" cell entrance and gene silencing efficacy of two tools, 2'-O-methyl phosphorotioate-modified oligonucleotides (2'-OMe-PS-ASOs) and polypurine reverse Hoogsteen hairpins (PPRHs), were evaluated in EL4 cells and cultured primary lymphocytes. Following B16 tumor transplant, C57BL6 mice were vaccinated with irradiated B16 tumor cells engineered to produce granulocyte-macrophage colony-stimulating factor (GM-CSF) and were intraperitoneally treated with CTLA4 and Foxp3 2'-OMe-PS-ASO before and after vaccination. Tumor growth, mice survival, and CTLA4 and Foxp3 expression in blood cells were measured. The following results were obtained: 1) only 2'-OMe-PS-ASO reached gene silencing efficacy "in vitro"; 2) an improved survival effect was achieved combining both therapeutic vaccine and Foxp3 antisense or CTLA4 antisense oligonucleotides (50% and 20%, respectively); 3) The blood CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> (Treg) and CD4<sup>+</sup>CTLA4<sup>+</sup> cell counts were higher in mice that developed tumor on the day of sacrifice. Our data showed that tumor cell vaccine combined with Foxp3 or CTLA4 gene silencing can increase the efficacy of therapeutic antitumor vaccination.
Dynamic provenance for SPARQL updates using named graphs (2014)

While the (Semantic) Web currently does have a way to exhibit static provenance information in the W3C PROV standards, the Web does not have a way to describe dynamic changes to data. While some provenance models and annotation techniques originally developed with databases or workflows in mind transfer readily to RDF, RDFS and SPARQL, these techniques do not readily adapt to describing changes in dynamic RDF datasets over time. In this paper we explore how to adapt the dynamic copy-paste provenance model of Buneman et al. to RDF datasets that change over time in response to SPARQL updates, how to represent the resulting provenance records themselves as RDF using named graphs in a manner compatible with W3C PROV, and how the provenance information can be provided as a SPARQL query. The primary contribution is a semantic framework that enables the semantics of SPARQL Update to be used as the basis for a `cut-and-paste' provenance model in a principled manner.
Usefulness of Spectral Range Profile in Quantitative Assessment of Voice Quality in Adults and Children (2017)

Objectives: This study aims to assess the usefulness of spectral range profile (SRP) for quantitative assessment of voice quality in vocally healthy singers and non-singers groups differentiated by age and gender. Study Design: Prospective study. Methods: SRP in combination with voice range profile (VRP) using standard singing voice protocols were derived from 57 vocally healthy adults (13 trained choir singers, 44 non-singers) and from 23 vocally healthy prepubescent children (12 choir singers, 11 non-singers). Spectral voice quality parameter -coefficient of sound was calculated as the percent ratio of the sound pressure level (SPL) in the singer's formant frequency region between 2.6 and 3.7 kHz and the SPL of fundamental frequency for fortissimo singing. Results: When compared with non-singers, both genders of adult singers demonstrated a significantly greater average values of coefficient of sound (P<0.05), while no statistically significant differences were found for this parameter in the children groups. The logistic regression analysis revealed that coefficient of sound for adults and pitch range for children were selected as the key predictors of well-equipped voice. The limiting score of the coefficient of sound of 84.5 % distinguishing singers and non-singers according to ROC curve, has the sensitivity of 100% and specificity of 90.9%. Conclusions: Our study suggests that measurement of spectral range profile may be helpful for quantitative assessment of voice quality in adults, and could be recommended for phoniatricians and speech-language pathologists in their clinical practice.
Polymorphism in<i>Bordetella pertussis</i>Pertactin and Pertussis Toxin Virulence Factors in the United States, 1935–1999 (2000)

To elucidate the potential role of the etiologic agent in recent increases of pertussis incidence in the United States, we studied the polymorphism in pertactin and pertussis toxin, which are Bordetella pertussis proteins important for pathogenesis and immunity. We sequenced regions of their genes (prn and ptx) in 152 B. pertussis strains isolated from 1935 through 1999 and identified 2 prn sequences: prn1 (old), observed continuously since 1935, and prn2 (new), not recognized until 1981 but seen in 97% of tested isolates in 1999. There were 3 ptx S1 subunit sequences: ptxS1D (old) was identified in 3 strains (1935 and 1939); ptxS1B (old) represented 87% of the strains recovered during 1935-1974; and ptxS1A (new) was the most prevalent during 1975-1987 and 1989-1999 (64% and 78%, respectively). Potential association between vaccination and the observed shift from old to new types requires further study. Our results provide the basis for prospectively monitoring for changes among circulating B. pertussis that might have epidemiologic relevance.
Insight lab (1998)

Article Free Access Share on Insight lab: an immersive team environment linking paper, displays, and data Authors: Beth M. Lange Center for Strategic Technology Research, 3773 Willow Road, Northbrook, IL Center for Strategic Technology Research, 3773 Willow Road, Northbrook, ILView Profile , Mark A. Jones Center for Strategic Technology Research, 3773 Willow Road, Northbrook, IL Center for Strategic Technology Research, 3773 Willow Road, Northbrook, ILView Profile , James L. Meyers Center for Strategic Technology Research, 3773 Willow Road, Northbrook, IL Center for Strategic Technology Research, 3773 Willow Road, Northbrook, ILView Profile Authors Info & Claims CHI '98: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsJanuary 1998Pages 550–557https://doi.org/10.1145/274644.274718Published:01 January 1998Publication History 37citation776DownloadsMetricsTotal Citations37Total Downloads776Last 12 Months56Last 6 weeks10 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Publisher SiteeReaderPDF
Hydrophobically Modified Associative Polymer Solutions:  Rheology and Microstructure in the Presence of Nonionic Surfactants (2002)

We report on the rheology and morphology of a hydrophobically modified alkali-swellable emulsion (HASE) polymer solubilized in alkaline media containing nonionic surfactants. The HASE polymer consists of complex alkylaryl hydrophobes composed of oligomeric nonylphenol condensates attached to a poly(ethyl acrylate-co-methacrylic acid) backbone. The complex linear viscoelastic response of the polymer in alkaline solution suggests an unentangled network with an appreciable fraction of microgel. The concentration and hydrophile−lipophile balance (HLB) of nonionic surfactants profoundly affect the solution rheology. A surfactant of high HLB inhibits the dynamic network connectivity of the HASE polymer, as demonstrated by reductions of both the steady-shear viscosity and the dynamic storage modulus. The shear-induced structuring previously reported for this polymer is also progressively diminished as the surfactant concentration is increased. In contrast, the addition of a low-HLB surfactant promotes system structuring, as evidenced by (i) increases in the shear viscosity and the high-frequency plateau modulus and (ii) retention of the ability to undergo shear-induced structuring. We also employ cryofracture-replication transmission electron microscopy for the first time with regard to HASE associative polymers to examine the morphological characteristics of selected systems. The morphology of the HASE polymer in both latex and solubilized form appears more complex than previously anticipated, and a reasonable interpretation of these new data is provided.
Dry‐jet‐wet spun polyurethane fibers. I. Optimization of the spinning parameters (2010)

Abstract This study examined the spinning of polyurethane‐based elastomeric fibers with the dry‐jet‐wet spinning method. The three important spinning variables that were chosen were the coagulation bath ratio (dimethylformamide/water), the bath temperature, and the stretch ratio. A three‐variable factorial design method, proposed by Box and Behnken, was used to optimize these process parameters. The spinning process was further fine‐tuned by the variation of the stretch ratio and the dope solid content. The effect of the dry‐jet length on the fiber properties was also studied. The tenacity and elastic recovery properties of the fibers were found to be optimum at a bath ratio (dimethylformamide/water) of 60 : 40, a bath temperature of 15°C, and a stretch ratio of 2.5. The density and sonic modulus were measured to determine the effect of varying the process variables on structural parameters such as the density and orientation. The surface morphological features, as revealed by scanning electron microscopy, were correlated to the fiber properties. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Linking Temporal Records for Profiling Entities (2015)

To harness the rich amount of information available on the Web today, many organizations start to aggregate public (and private) data to derive new knowledge bases. A fundamental challenge in constructing an accurate integrated knowledge repository from different data sources is to understand how facts across different sources are related to one another over time. This challenge, referred to as the temporal record linkage problem, goes far beyond the traditional record linkage problem as it requires a fine-grained analysis of how two facts are temporally related if they both refer to the same entity.
Evaluation of the use of a subunit classical swine fever marker vaccine under field conditions in Mexico (2003)

Vaccination with an E2 subunit classical swine fever (CSF) marker vaccine (Porcilis pesti; Intervet International, Boxmeer, Netherlands) appeared to limit the number of new outbreaks in an endemic area. An ELISA that identifies antibodies to the CSF Erns protein differentiated vaccinated and infected pigs in vaccinated herds.