gebhart/patrepeval huggingface dataset:
Potential Desorbents for Propane/Propylene Separation by Gas Phase Simulated Moving Bed: A Molecular Simulation Study (2010)

This paper is focused on using molecular simulation as a tool to guide the choice of desorbent for the separation propane/propylene by simulated moving bed (SMB) processes. Equilibrium adsorption isotherms of n-butane and neopentane on zeolite 13X and adsorption equilibria of binary mixtures of each one of these adsorbates with propane and with propylene were obtained by molecular simulation, in a predictive screening of an adequate desorbent for the separation of propane/propylene by the SMB technology. Comparisons of experimental isotherms with grand canonical Monte Carlo simulations in zeolite 13X showed that the results of n-butane are in excellent agreement with reported simulations and experimental data. The carbon−cation interactions for the quaternary carbon atom of neopentane were established and validated through determination of adsorption properties of binary mixtures of neopentane with propane and with propylene. The lack of experimental data of neopentane adsorption motivated the present study, providing the opportunity to predict the single adsorption isotherms over a temperature range from 273 to 423 K and pressures up to 150 kPa. From the simulated isotherms of neopentane in 13X zeolite, the isosteric heat of adsorption of 39.19 kJ/mol was calculated by using the Clausius−Clapeyron equation, in close agreement with the published value of 41.7 kJ/mol. Additionally, the simulation results of the binary mixtures with propane and with propylene showed that neopentane and propane have similar affinities to the adsorbent, which indicates a less favorable desorption effect for neopentane, compared with that of n-butane.
Dynamical modalities in Kerr frequency combs (Conference Presentation) (2018)

Recent advances in sub-wavelength nanoscale platforms have afforded the control of light from first principles, with impact to ultrafast sciences, optoelectronics and precision measurements. In this talk we will describe recent advances in chip-scale Kerr frequency comb oscillators, where we have achieved sub-100-fs mode-locking, stabilization down to a tooth-to-tooth relative frequency uncertainty of 50 mHz and 2.7×10^{−16}, and single-mode broadband frequency comb generation. Each of these are supported by linear and nonlinear numerical modeling. In this first chip-scale realization, coherent mode-locking is observed in the normal dispersion regime, verified by phase-resolved ultrafast spectroscopy at sub-100-attojoule sensitivities. The normal dispersion architecture uncovers the mode-locking mechanisms in Kerr frequency combs, matched with first-principles coupled-mode theory. In the second realization, we examine the noise limits in the full stabilization of chip-scale optical frequency combs. The microcomb’s two degrees of freedom, one of the comb lines and the native 18-GHz comb spacing, are simultaneously phase-locked to known optical and microwave references. Active comb spacing stabilization improves long-term stability by six orders of magnitude, reaching a record instrument-limited residual instability of 3.6 mHz per root tau. Comparing 46 nitride frequency comb lines with a benchmark fiber laser frequency comb, we demonstrate the unprecedented microcomb tooth-to-tooth relative frequency uncertainty down to 50 mHz and 2.7×10^{−16}. In the third realization, we report a novel design of Si3N4 microresonator in which single-mode operation, high quality factor, and anomalous dispersion are attained simultaneously. The novel microresonator consists of uniform single-mode waveguides in the semi-circle region, to eliminate bending induced mode coupling, and adiabatically tapered waveguides in the straight region, to avoid excitation of higher order modes. With this microresonator, we demonstrate broadband phase-locked frequency combs. This supports the focus towards chip-scale precision spectroscopy, timing, coherent communications, and astronomical spectrography.
Two-dimensional imaging of heavily shielded materials by NRF with laser-compton photon beam (2010)

Experimental demonstration of a two-dimensional imaging was done by an emission radiography method based on nuclear resonance fluorescence (NRF) and a gamma-ray spectrometry. A wedge-shaped specimen made of natural lead, which simulated a special nuclear material, hidden in a radiation-shielding box made of natural iron was prepared. A photon beam of 5600 keV was generated using an electron storage ring TERAS of AIST, via the laser Compton scattering. The photon beam was collimated to 5 mm in diameter, and incident on the specimen through the radiation-shielding box. The energy spectrum of NRF gamma-rays emerged from the specimen was measured with a high-purity germanium gamma-ray spectrometer, and the full-energy peak was analyzed. The peak intensity was measured in various position to visualize the specimen by 2-D radiograph as we scan the specimen with respect to the photon beam. We successfully obtained a 2-D radiograph of the specimen.
BRAVO -- Biased Locking for Reader-Writer Locks (2018)

Designers of modern reader-writer locks confront a difficult trade-off related to reader scalability. Locks that have a compact memory representation for active readers will typically suffer under high intensity read-dominated workloads when the "reader indicator"' state is updated frequently by a diverse set of threads, causing cache invalidation and coherence traffic. Other designs, such as cohort reader-writer locks, use distributed reader indicators, one per NUMA node. This improves reader-reader scalability, but also increases the size of each lock instance. We propose a simple transformation BRAVO, that augments any existing reader-writer lock, adding just two integer fields to the lock instance. Readers make their presence known to writers by hashing their thread's identity with the lock address, forming an index into a visible readers table. Readers attempt to install the lock address into that element in the table, making their existence known to potential writers. All locks and threads in an address space can share the visible readers table. Updates by readers tend to be diffused over the table, resulting in a NUMA-friendly design. Crucially, readers of the same lock tend to write to different locations in the array, reducing coherence traffic. Specifically, BRAVO allows a simple compact lock to be augmented so as to provide scalable concurrent reading but with only a modest increase in footprint.
Genetic Transformation of Iris germanica Mediated by Agrobacterium tumefaciens (1999)

A protocol was developed for production of transgenic iris plants ( Iris germanica L. `Skating Party') from regenerable suspension cultures via Agrobacterium -mediated transformation. We tested a series of selection agents, and identified hygromycin and geneticin as the most suitable for selecting transformed iris cells. Suspension cultures of iris were cocultured for 3 days with A. tumefaciens LBA 4404(pTOK233) carrying an intron-interrupted uidA (GUS) gene encoding β-glucuronidase, and hpt (hygromycin) and nptII (geneticin) selectable marker genes. Hygromycin- or geneticin-resistant calli having GUS enzyme activity were identified and used to induce plant regeneration. More than 300 morphologically normal transgenic iris plants were obtained in ≈6 months. About 80% of the transformants were GUS-positive and NPTII-positive (paromomycin-resistant). Integration of transgenes into the nuclear genome of iris plants was confirmed by Southern blot analysis. We have, therefore, developed an efficient A. tumefaciens -mediated transformation system for Iris germanica , which will allow future improvement of this horticulturally important ornamental monocot via genetic engineering.
Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation (2016)

Since it emerged in Brazil in May 2015, the mosquito-borne Zika virus (ZIKV) has raised global concern due to its association with a significant rise in the number of infants born with microcephaly and neurological disorders such as Guillain-Barré syndrome. We developed prototype subunit and adenoviral-based Zika vaccines encoding the extracellular portion of the ZIKV envelope gene (E) fused to the T4 fibritin foldon trimerization domain (Efl). The subunit vaccine was delivered intradermally through carboxymethyl cellulose microneedle array (MNA). The immunogenicity of these two vaccines, named Ad5.ZIKV-Efl and ZIKV-rEfl, was tested in C57BL/6 mice. Prime/boost immunization regimen was associated with induction of a ZIKV-specific antibody response, which provided neutralizing immunity. Moreover, protection was evaluated in seven-day-old pups after virulent ZIKV intraperitoneal challenge. Pups born to mice immunized with Ad5.ZIKV-Efl were all protected against lethal challenge infection without weight loss or neurological signs, while pups born to dams immunized with MNA-ZIKV-rEfl were partially protected (50%). No protection was seen in pups born to phosphate buffered saline-immunized mice. This study illustrates the preliminary efficacy of the E ZIKV antigen vaccination in controlling ZIKV infectivity, providing a promising candidate vaccine and antigen format for the prevention of Zika virus disease.
CHOP: Integrating DRAM Caches for CMP Server Platforms (2010)

Integrating large DRAM caches is a promising way to address the memory bandwidth wall issue in the many-core era. However, organizing and implementing a large DRAM cache imposes a trade-off between tag space overhead and memory bandwidth consumption. CHOP (Caching Hot Pages) addresses this trade-off through three filter-based DRAM-caching techniques.
A Convenient Synthesis of π-Allylpalladium Compounds from Monosubstituted Terminal Olefins (1979)

Abstract There has been considerable recent interest in new applications of π-allylpalladium compounds in organic synthesis.2,3 In our own work on the synthesis of prostaglandin endoperoxide analogs, we had need of π-allylpalladium compounds of the following type where X is a functional group. W e had originally hoped to prepare these compounds directly from the corresponding terminal olefins. Unfortunately however, the most widely used methods for the direct conversion of olefins to π-allylpalladium compounds apparently are not applicable to monosubstituted terminal olef ins,4–8 and those which appeared applicable either gave very low yields, mixtures of π-allylpalladium compounds,11 or no product at a11.12 An equally important route to π-allylpalladium compounds employs allylic chlorides and palladium(I1) salts.13–15 Unfortunately, allylic chlorides are difficult compounds to handle and one would prefer to avoid isolating these compounds if at all possible.
A Comparative Study on the Dynamic Response of Three Semisubmersible Floating Offshore Wind Turbines (2019)

Abstract Currently, there is a great interest to globally develop offshore wind energy due to the greenhouse effect and energy crisis. Great efforts have been devoted to develop reliable floating offshore wind energy technology to exploit the wind energy resources in deep seas. This paper presents a comparative study of the dynamic response of three different semisubmersible floating wind turbine structures. All the three platforms support the same 5MW wind turbine. The platforms examined are: a V-shaped Semi, an OC4-DeepCwind Semi and a Braceless Semi at 200 m water depth. A dynamic analysis is carried out in order to calculate and compare the performance of these platforms. The comparison is made on the rigid body motions of the semisubmersible platform and tensions of the mooring lines. The presented comparison is based on statistical values and spectra of the time series of the examined response quantities. Coupling effects are more significant for the V-shaped Semi platform. The V-shaped Semi and the Braceless Semi show a more rational motion response under the investigated load cases. The results of this analysis may help to resolve the fundamental design tradeoffs between among different floating system concepts.
Single mode lasing in a 200&#x003BC;m diameter core gain-guided index anti-guided diode end pumped fiber (2007)

Single mode laser oscillation is achieved in a 200 μum diameter core end pumped gain guided index anti-guided fiber. The near-Gaussian beam quality of the laser is maintained at up to four times laser threshold.
A Fruiting Body Tissue Method for Efficient <i>Agrobacterium</i> -Mediated Transformation of <i>Agaricus bisporus</i> (2000)

We describe a modified Agrobacterium-mediated method for the efficient transformation of Agaricus bisporus. Salient features of this procedure include cocultivation of Agrobacterium and fruiting body gill tissue and use of a vector with a homologous promoter. This method offers new prospects for the genetic manipulation of this commercially important mushroom species.
Tunable insertion of multiple lines into a Kerr frequency comb using electro-optical modulators (2017)

We experimentally insert a flexible number of electro-optical (EO) comb lines into a Kerr frequency comb via EO modulation and demonstrate the use of combined Kerr and EO combs as light sources in coherent communications. The number of EO lines inserted into the Kerr comb can be varied by changing the modulation frequency. Additionally, the inserted EO comb is found to have similar coherence to that of the Kerr comb, as indicated by their linewidths. The high coherence of both the Kerr and EO combs has further been demonstrated in a communication experiment in which the comb lines are encoded with 10 Gbaud quadrature phase-shift-keyed signals. The increased number of comb lines after EO modulation indicates the possibility of obtaining more data channels in optical communications.
Series-wound heteropolar inductor motor for automotive applications (2016)

This work considers a method of control for a heteropolar inductor motor for use in automotive applications. Previously, power factor for this type of machine was considered to be too low, and operation in the high-speed / constant-power region was not easily realized. To make the machine amenable to control with an automotive inverter and to eliminate the need for a separate field controller, the field winding is driven by a rectifier bridge attached in series to the phase windings. Motor currents are then prescribed by a novel vector control scheme that realizes high power factor over a wide range of operation.
Structure activity correlations of biodegradability of DDT analogs (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure activity correlations of biodegradability of DDT analogsInder P. Kapoor, Robert L. Metcalf, Asha S. Hirwe, Joel R. Coats, and Mohinder S. KhalsaCite this: J. Agric. Food Chem. 1973, 21, 2, 310–315Publication Date (Print):March 1, 1973Publication History Published online1 May 2002Published inissue 1 March 1973https://pubs.acs.org/doi/10.1021/jf60186a044https://doi.org/10.1021/jf60186a044research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
p66 Shc Tumor Levels Show a Strong Prognostic Correlation with Disease Outcome in Stage IIA Colon Cancer (2007)

Measuring p66 Shc tumor levels provides a unique and simple tool for stratifying stage IIA colon cancer patients by risk of recurrence and disease-specific death and may assist in determining treatment strategies for these patients.
Single-step copying process for multiplexed volume holograms (1992)

A technique for copying the index or absorption modulation of a multiplexed volume holographic element into a second volume holographic medium is presented. The technique utilizes a set of coherent but mutually incoherent optical sources and can perform the copy process in a single exposure step. The concept is demonstrated experimentally for the case of three angularly multiplexed holographic gratings in dichromated gelatin.
Progress in the Development of Plasma Panel Radiation Detectors (2010)

Plasma Display Panels (PDP), the underlying engine of panel plasma television displays, are being investigated for their utility as radiation detectors called Plasma Panel Sensors (PPS). The PPS a novel variant of a micropattern radiation detector, is intended to be a fast, high resolution detector comprised of an array of plasma discharge cells operating in a hermetically sealed gas mixture. We report on the PPS development effort, including recent laboratory measurements.
IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform (2021)

The long-term prognosis of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) is still unsatisfactory even after the emergence of tyrosine kinase inhibitors (TKIs) against chimeric BCR-ABL, and this is associated with the high incidence of genetic alterations of Ikaros family zinc finger 1 (IKZF1), most frequently the hemi-allelic loss of exons 4-7 expressing a dominant-negative isoform Ik6. We found that lenalidomide (LEN), a representative of immunomodulatory drugs (IMiDs), which have been long used for the treatment of multiple myeloma, specifically induced accumulation of Ik6 with the disappearance of functional isoforms within 24 h (i.e., abrupt and complete shut-down of the IKZF1 activity) in Ik6-positive Ph+ALL cells in a neddylation-dependent manner. The functional IKZF3 isoforms expression was also abruptly and markedly downregulated. The LEN treatment specifically suppressed proliferation of Ik6-positive-Ph+ALL cells by inducing cell cycle arrest via downregulation of cyclins D3 and E and CDK2, and of importance, markedly upregulated their apoptosis in synergy with the TKI imatinib (IM). Apoptosis of IM-resistant Ph+ALL cells with T315I mutation of BCR-ABL was also upregulated by LEN in the presence of the newly developed TKI ponatinib. Analyses of flow cytometry, western blot, and oligonucleotide array revealed that apoptosis was caspase-/p53-dependent and associated with upregulation of pro-apoptotic Bax/Bim, enhanced dephosphorylation of BCR-ABL/Akt, and downregulation of oncogenic helicase genes HILLS, CDC6, and MCMs4 and 8. Further, the synergism of LEN with IM was clearly documented as a significant prolongation of survival in the xenograft mice model. Because this synergism was further potentiated in vitro by dexamethasone, a key drug for ALL treatment, the strategy of repositioning IMiDs for the treatment of Ik6-positive Ph+ALL patients certainly shed new light on an outpatient-based treatment option for achieving their long-term durable remission and higher QOL, particularly for those who are not tolerable to intensified therapeutic approaches.
Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound (2020)

<i>Plasmodium falciparum</i> parasites are increasingly drug-resistant, requiring the search for novel antimalarials with distinct modes of action. Enzymes in the glutathione pathway, including glutathione S-transferase (GST), show promise as novel antimalarial targets. This study aims to better understand the biological function of <i>Plasmodium</i> GST, assess its potential as a drug target, and identify novel antiplasmodial compounds using the rodent model <i>P. berghei</i>. By using reverse genetics, we provided evidence that GST is essential for survival of <i>P. berghei</i> intra-erythrocytic stages and is a valid target for drug development. A structural model of the <i>P. berghei</i> glutathione S-transferase (PbGST) protein was generated and used in a structure-based screening of 900,000 compounds from the ChemBridge Hit2Lead library. Forty compounds were identified as potential inhibitors and analyzed in parasite <i>in vitro</i> drug susceptibility assays. One compound, CB-27, exhibited antiplasmodial activity with an EC<sub>50</sub> of 0.5 μM toward <i>P. berghei</i> and 0.9 μM toward <i>P. falciparum</i> multidrug-resistant Dd2 clone B2 parasites. Moreover, CB-27 showed a concentration-dependent inhibition of the PbGST enzyme without inhibiting the human ortholog. A shape similarity screening using CB-27 as query resulted in the identification of 24 novel chemical scaffolds, with six of them showing antiplasmodial activity ranging from EC<sub>50</sub> of 0.6-4.9 μM. Pharmacokinetic and toxicity predictions suggest that the lead compounds have drug-likeness properties. The antiplasmodial potency, the absence of hemolytic activity, and the predicted drug-likeness properties position these compounds for lead optimization and further development as antimalarials.
Multilevel Converters: An Enabling Technology for High-Power Applications (2009)

Multilevel converters are considered today as the state-of-the-art power-conversion systems for high-power and power-quality demanding applications. This paper presents a tutorial on this technology, covering the operating principle and the different power circuit topologies, modulation methods, technical issues and industry applications. Special attention is given to established technology already found in industry with more in-depth and self-contained information, while recent advances and state-of-the-art contributions are addressed with useful references. This paper serves as an introduction to the subject for the not-familiarized reader, as well as an update or reference for academics and practicing engineers working in the field of industrial and power electronics.
Identification of an evolutionarily conserved, function-associated molecule on human natural killer cells. (1991)

Nonspecific cytotoxic cells (NCC) in teleost fish are analogous to human natural killer (NK) cells and spontaneously lyse a variety of transformed human cell lines sensitive to human NK cell lysis. Monoclonal antibodies (mAbs) made against these NK-like effector cells inhibited their lytic activity. These anti-NCC mAbs were examined with human NK cells for their effects. It was observed that these mAbs bound specifically to a small percentage of peripheral blood lymphocytes (5-15%) and to the majority (greater than 85%) of CD3- NK cells. The mAbs inhibited human NK cell lysis against a variety of transformed cell lines. Single-cell assays showed that the mAbs exerted their effects through inhibition of conjugate formation (recognition). However, the mAbs did not inhibit NK cell-mediated antibody-dependent cell-mediated cytotoxicity. Biochemical analysis of the NK cell molecule revealed that a dimeric structure was involved (distinct from antigen receptors on T cells). Thus, this molecule appears to be a candidate NK cell antigen receptor.