gebhart/patrepeval huggingface dataset:
Relationships among chromatic tone, perceived lightness, and degree of vividness (2005)

The present study describes the usefulness and importance of chromatic tone concept on object colors. It is clarified that the concept of a tone category consists of the same perceived lightness and the same degree of vividness of chromatic object colors in the tone irrespective of hue. Prediction equations are given to color attributes on perceived lightness and degree of vividness. They clearly show different functions on metric lightness and metric chroma on the two color attributes. It is also clarified that the theoretical opponent-colors system by the author (NT system) gives a basis for defining the tone concept, perceived lightness, and degree of vividness. The results of the present study are useful for understanding fundamental color notion “tone,” which is important both in the fields of colorimetry (fundamental color-perception study) and color design (practical application). In addition, attributes of equivalent whiteness–blackness [W-Bk]eq and equivalent chroma Ceq are proposed. © 2005 Wiley Periodicals, Inc. Col Res Appl, 30, 221–234, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.20108
An Unexpected Role of Hyaluronic Acid in Trafficking siRNA Across the Cellular Barrier: The First Biomimetic, Anionic, Non‐Viral Transfection Method (2019)

Abstract Circulating nucleic acids, such as short interfering RNA (siRNA), regulate many biological processes; however, the mechanism by which these molecules enter the cell is poorly understood. The role of extracellular‐matrix‐derived polymers in binding siRNAs and trafficking them across the plasma membrane is reported. Thermal melting, dynamic light scattering, scanning electron microscopy, and computational analysis indicate that hyaluronic acid can stabilize siRNA via hydrogen bonding and Van der Waals interactions. This stabilization facilitated HA size‐ and concentration‐dependent gene silencing in a CD44‐positive human osteosarcoma cell line (MG‐63) and in human mesenchymal stromal cells (hMSCs). This native HA‐based siRNA transfection represents the first report on an anionic, non‐viral delivery method that resulted in approximately 60 % gene knockdown in both cell types tested, which correlated with a reduction in translation levels.
Interview With Robert Coffin, Inventor of T-VEC: The First Oncolytic Immunotherapy Approved for the Treatment of Cancer (2016)

Interviewed by Ellen Clarke, Commissioning Editor, Future Science Group. Robert Coffin is co-founder and CEO of Replimune. Previously he was Founder and CTO of BioVex Inc, a spin out from his research group at University College London in 1999. He was the inventor of all BioVex products including OncoVEXGM-CSF (talimogene laherparepvec; T-VEC; Imlygic) and oversaw all research and clinical development including bringing T-VEC through to two pivotal Phase 3 studies in melanoma and head and neck cancer. BioVex was acquired by Amgen in 2011 where he was VP Global Development until 2013. T-VEC was approved by the FDA for use in advanced melanoma in October 2015, the first oncolytic therapy or gene therapy to be approved in USA. He was awarded a PhD in virology from Imperial College London prior to his move to University College London in 1991.
miR-17∼92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease (2013)

Polycystic kidney disease (PKD), the most common genetic cause of chronic kidney failure, is characterized by the presence of numerous, progressively enlarging fluid-filled cysts in the renal parenchyma. The cysts arise from renal tubules and are lined by abnormally functioning and hyperproliferative epithelial cells. Despite recent progress, no Food and Drug Administration-approved therapy is available to retard cyst growth. MicroRNAs (miRNAs) are short noncoding RNAs that inhibit posttranscriptional gene expression. Dysregulated miRNA expression is observed in PKD, but whether miRNAs are directly involved in kidney cyst formation and growth is not known. Here, we show that miR-17∼92, an oncogenic miRNA cluster, is up-regulated in mouse models of PKD. Kidney-specific transgenic overexpression of miR-17∼92 produces kidney cysts in mice. Conversely, kidney-specific inactivation of miR-17∼92 in a mouse model of PKD retards kidney cyst growth, improves renal function, and prolongs survival. miR-17∼92 may mediate these effects by promoting proliferation and through posttranscriptional repression of PKD genes Pkd1, Pkd2, and hepatocyte nuclear factor-1β. These studies demonstrate a pathogenic role of miRNAs in mouse models of PKD and identify miR-17∼92 as a therapeutic target in PKD. Our results also provide a unique hypothesis for disease progression in PKD involving miRNAs and regulation of PKD gene dosage.
Versatility and remarkable hypergolicity of exo-6, exo-9 imidazole-substituted nido-decaborane (2017)

The combination of an energetic imidazole bonded to a hypergolic trigger, such as certain boron hydride clusters, dramatically improves both the energy density and ignition delay of the resulting compounds while also introducing tunability via alkyl group substitution as demonstrated here with (Rim)<sub>2</sub>B<sub>10</sub>H<sub>12</sub> (R = H, C<sub>1</sub>, C<sub>2</sub>, and C<sub>4</sub>).
Rectal suppository insertion: the reliability of the evidence as a basis for nursing practice (2006)

Inserting rectal suppositories, whether as a medication or to achieve bowel evacuation, is a very common healthcare practice. Currently, there is inconsistency and discrepancy in the correct method for this procedure in both nursing education and practice. This paper examines the reliability of existing evidence and shows the need for further work in order to provide a reliable evidence base for this commonplace clinical procedure.
-Thalassemia Intermedia: A Clinical Perspective (2012)

Our understanding of the molecular and pathophysiological mechanisms underlying the disease process in patients with β-thalassemia intermedia has substantially increased over the past decade. Earlier studies observed that patients with β-thalassemia intermedia experience a clinical-complications profile that is different from that in patients with β-thalassemia major. In this article, a variety of clinical morbidities are explored, and their associations with the underlying disease pathophysiology and risk factors are examined. These involve several organs and organ systems including the vasculature, heart, liver, endocrine glands, bone, and the extramedullary hematopoietic system. The effects of some therapeutic interventions on the development of clinical complications are also discussed.
Macromol. Symp. 272 (2008)

Cover: The cover shows a molecular dynamics simulated transition‐state (TS) structures of γ‐acyloxy‐ε‐caprolactones in the formation of the acyl‐enzyme in Candida antarctica lipase B. It is selected from the article by Keul, p.28.
Electrical Power Generation Using Footsteps (2018)

Electricity is the most general forms of energy used across the world. This paper focuses on designing a setup that leads to the generation of electrical energy which is going to waste when humans are walking. Footsteps are an untapped natural resources. This generated energy is, however, costeffective and nonhazardous for human. Electrical energy can be produced by converting mechanical energy using footsteps. Generating the electric power through the fabrication of footstep arrangement by a prototype comprises of a pipe, nozzle, unidirectional valve, water reservoir, turbine, and DC motor. Whenever pressure is exerted on the reservoir, water flows through the nozzle into the turbine and generates electrical energy. This energy is stored in the battery. This project will reduce the global warming and load shedding in a much cleaner cost-effective way. Since this project is related directly to the human movement, the weight of the setup is a crucial factor.
Influence of systematic errors in reference states on image quality and on stability of derived information for dc optical imaging (2001)

Optical measurements of tissue can be performed in discrete, time-averaged, and time-varying data collection modes. This information can be evaluated to yield estimates of either absolute optical coefficient values or some relative change in these values compared with a defined state. In the case of time-varying data, additional analysis can be applied to define various dynamic features. Here we have explored the accuracy with which such information can be recovered from dense scattering media using linear perturbation theory, as a function of the accuracy of the reference medium that serves as the initial guess. Within the framework of diffusion theory and a first-order solution, we have observed the following inequality regarding the sensitivity of computed measures to inaccuracy in the reference medium: Absolute measures ? relative measures > dynamic measures. In fact, the fidelity of derived dynamic measures was striking; we observed that accurate measures of dynamic behavior could be defined even if the quality of the image data from which these measures were derived was comparatively modest. In other studies we identified inaccuracy in the estimates of the reference detector values, and not to corresponding errors in the image operators, as the primary factor responsible for instability of absolute measures. The significance of these findings for practical imaging studies of tissue is discussed.
Novel Compounds Containing Multiple Guanide Groups That Bind the HIV Coreceptor CXCR4 (2010)

The G-protein-coupled receptor CXCR4 acts as a coreceptor for human immunodeficiency virus type 1 (HIV-1) infection, as well as being involved in signaling cell migration and proliferation. Compounds that block CXCR4 interactions have potential uses as HIV entry inhibitors to complement drugs such as maraviroc that block the alternate coreceptor CCR5 or in cancer therapy. The peptide T140, which contains five arginine residues, is the most potent antagonist of CXCR4 developed to date. In a search for nonpeptide CXCR4 ligands that could inhibit HIV entry, three series of compounds were synthesized from 12 linear and branched polyamines with 2, 3, 4, 6, or 8 amino groups, which were substituted to produce the corresponding guanidines, biguanides, or phenylguanides. The resulting compounds were tested for their ability to compete with T140 for binding to the human CXCR4 receptor expressed on mammalian cells. The most effective compounds bound CXCR4 with a 50% inhibitory concentration of 200 nM, and all of the compounds had very low cytotoxicity. Two series of compounds were then tested for their ability to inhibit the infection of TZM-bl cells with X4 and R5 strains of HIV-1. Spermine phenylguanide and spermidine phenylguanide inhibited infection by X4 strains, but not by R5 strains, at low micromolar concentrations. These results support further investigation and development of these compounds as HIV entry inhibitors.
Remodeling of Blood Vessels (2005)

Vascular functions, including tissue perfusion and peripheral resistance, reflect continuous structural adaptation (remodeling) of blood vessels in response to several stimuli. Here, a theoretical model is presented that relates the structural and functional properties of microvascular networks to the adaptive responses of individual segments to hemodynamic and metabolic stimuli. All vessels are assumed to respond, according to a common set of adaptation rules, to changes in wall shear stress, circumferential wall stress, and tissue metabolic status (indicated by partial pressure of oxygen). An increase in vessel diameter with increasing wall shear stress and an increase in wall mass with increased circumferential stress are needed to ensure stable vascular adaptation. The model allows quantitative predictions of the effects of changes in systemic hemodynamic conditions or local adaptation characteristics on vessel structure and on peripheral resistance. Predicted effects of driving pressure on the ratio of wall thickness to vessel diameter are consistent with experimental observations. In addition, peripheral resistance increases by approximately 65% for an increase in driving pressure from 50 to 150 mm Hg. Peripheral resistance is predicted to be markedly increased in response to a decrease in vascular sensitivity to wall shear stress, and to be decreased in response to increased tissue metabolic demand. This theoretical approach provides a framework for integrating available information on structural remodeling in the vascular system and predicting responses to changing conditions or altered vascular reactivity, as may occur in hypertension.
The 66-kDa Shc Isoform Is a Negative Regulator of the Epidermal Growth Factor-stimulated Mitogen-activated Protein Kinase Pathway (1997)

In addition to tyrosine phosphorylation of the 66-, 52-, and 46-kDa Shc isoforms, epidermal growth factor (EGF) treatment of Chinese hamster ovary cells expressing the human EGF receptor also resulted in the serine/threonine phosphorylation of approximately 50% of the 66-kDa Shc proteins. The serine/threonine phosphorylation occurred subsequent to tyrosine phosphorylation and was prevented by pretreatment of the cells with the MEK-specific inhibitor PD98059. Surprisingly, only the gel-shifted 66-kDa Shc isoform (serine/threonine phosphorylated) was tyrosine phosphorylated and associated with Grb2. In contrast, only the non-serine/threonine-phosphorylated fraction of 66-kDa Shc was associated with the EGF receptor. To assess the relationship between the three Shc isoforms in EGF-stimulated signaling, the cDNA encoding the 66-kDa Shc species was cloned from a 16-day-old mouse embryo library. Sequence alignment confirmed that the 66-kDa Shc cDNA resulted from alternative splicing of the primary Shc transcript generating a 110-amino acid extension at the amino terminus. Co-immunoprecipitation of Shc and Grb2 from cells overexpressing the 52/46-kDa Shc isoforms versus the 66-kDa Shc species directly demonstrated a competition of binding for a limited pool of Grb2 proteins. Furthermore, expression of the 66-kDa Shc isoform markedly accelerated the inactivation of ERK following EGF stimulation. Together, these data indicate that the serine/threonine phosphorylation of 66-kDa Shc impairs its ability to associate with the tyrosine-phosphorylated EGF receptor and can function in a dominant-interfering manner by inhibiting EGF receptor downstream signaling pathways.
Tomographic image reconstruction from hollow projections (2003)

Deals with the tomographic image reconstruction problem from hollow projections. This kind of problem is mainly caused by an X-ray opaque obstruction contained in the object to be imaged. Based on the Cormack's (1964) inversion formula for the image reconstruction, the mathematical capability of image reconstruction from hollow projections is discussed and a new algorithm for the completion of hollow projections, which utilizes the regularized numerical evaluation of inverse CHT (Circular Harmonic Transform), is presented. In the numerical experiments, the performance of the proposed algorithm is demonstrated and significant improvement of the reconstructed image quality is obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Higher Risk of Venous Thrombosis During Early Use of Oral Contraceptives in Women With Inherited Clotting Defects (2000)

Women with inherited clotting defects who use oral contraceptives develop venous thrombosis not only more often but also sooner than do those without inherited clotting defects. Venous thrombosis in the first period of oral contraceptive use might indicate the presence of an inherited clotting defect.
NON-LINEAR VISCOELASTIC AND FATIGUE PROPERTIES OF ASPHALT BINDERS (1999)

A study was conducted to relate linear visco-elastic properties of asphalt binders of the same PG-Grade to the rheological properties of asphalt mixtures of same aggregate source, gradation, and volumetric proportions. The only variable was the type of modifier used in the production of the binder. Results indicated that linear properties are not good indicators of mixture response. The study was expanded to evaluate the role of non-linear viscoelastic properties in mixture response. The results collected indicate that modified and un-modified asphalt binders vary significantly in the non-linear behavior. The non-linear study was expanded to include fatigue performance of binders at various strain levels in the linear and non-linear range. The paper presents a parametric study showing factors that influence strain dependency of asphalt binders of a wide variety of chemical composition and modification techniques. The results of fatigue testing of the binders are also presented to show factors that influence fatigue behavior. This paper is intended to stimulate the research on the non-linear behavior of binders and to suggest that non-linear properties are essential for effective estimation of the role of binders in mixture behavior.
Rectified Wing Loss for Efficient and Robust Facial Landmark Localisation with Convolutional Neural Networks (2019)

Abstract Efficient and robust facial landmark localisation is crucial for the deployment of real-time face analysis systems. This paper presents a new loss function, namely Rectified Wing (RWing) loss, for regression-based facial landmark localisation with Convolutional Neural Networks (CNNs). We first systemically analyse different loss functions, including L2, L1 and smooth L1. The analysis suggests that the training of a network should pay more attention to small-medium errors. Motivated by this finding, we design a piece-wise loss that amplifies the impact of the samples with small-medium errors. Besides, we rectify the loss function for very small errors to mitigate the impact of inaccuracy of manual annotation. The use of our RWing loss boosts the performance significantly for regression-based CNNs in facial landmarking, especially for lightweight network architectures. To address the problem of under-representation of samples with large pose variations, we propose a simple but effective boosting strategy, referred to as pose-based data balancing. In particular, we deal with the data imbalance problem by duplicating the minority training samples and perturbing them by injecting random image rotation, bounding box translation and other data augmentation strategies. Last, the proposed approach is extended to create a coarse-to-fine framework for robust and efficient landmark localisation. Moreover, the proposed coarse-to-fine framework is able to deal with the small sample size problem effectively. The experimental results obtained on several well-known benchmarking datasets demonstrate the merits of our RWing loss and prove the superiority of the proposed method over the state-of-the-art approaches.
Microstructural-induced anisotropy in thin films for optical applications (1988)

Abstract Materials in thin-film form are much more interesting or much more trouble than their bulk counterparts, depending on your point of view. Most coatings are deposited at substrate temperatures considerably lower than the melting points of the evaporant materials, and the trend is generally toward even lower processing temperatures. In these films, the solid material is distributed in an array of fairly closely packed columns that run perpendicular to the substrate, and it is the columnar microstructure that has substantial influence over the physical behavior of the films. The microstructure is anisotropic and so are most thin film properties.
Fernsehwerbung aus der Sicht der Kreativen: Selbst-Beschreibungen (1994)

Lese-Hinweis: In diesem Kapitel fassen wir die Selbst-Beschreibungen der Kreativen in der Werbebranche zusammen. Aus Gründen der Lese(er)freundlichkeit haben wir uns für eine Darstellungsform entschieden, die Zusammenfassung, Bericht und Zitat miteinander verbindet. Um deutlich zu machen, daß wir hier nicht unsere eigene Meinung wiedergeben, haben wir gelegentlich Hinweise eingestreut wie “nach Ansicht der Kreativen” oder “wie unsere Interviewpartner meinen”. Auch wo solche Hinweise nicht gegeben werden, sollten sie freundlicherweise hinzugedacht werden.
An Image-based Approach to Understanding the Physics of MR Artifacts (2011)

As clinical magnetic resonance (MR) imaging becomes more versatile and more complex, it is increasingly difficult to develop and maintain a thorough understanding of the physical principles that govern the changing technology. This is particularly true for practicing radiologists, whose primary obligation is to interpret clinical images and not necessarily to understand complex equations describing the underlying physics. Nevertheless, the physics of MR imaging plays an important role in clinical practice because it determines image quality, and suboptimal image quality may hinder accurate diagnosis. This article provides an image-based explanation of the physics underlying common MR imaging artifacts, offering simple solutions for remedying each type of artifact. Solutions that have emerged from recent technologic advances with which radiologists may not yet be familiar are described in detail. Types of artifacts discussed include those resulting from voluntary and involuntary patient motion, magnetic susceptibility, magnetic field inhomogeneities, gradient nonlinearity, standing waves, aliasing, chemical shift, and signal truncation. With an improved awareness and understanding of these artifacts, radiologists will be better able to modify MR imaging protocols so as to optimize clinical image quality, allowing greater confidence in diagnosis.
Design of multiple feed per beam antenna based on a 3-d directional coupler topology (2012)

In this paper, an original Multiple-Feed per Beam (MFB) focal array architecture is designed. Significant overlapping of the feed clusters is achieved to enhance illumination performances within a size-constrained lattice. This focal array is set in front of a reflector to produce multiple beams with frequency and polarization re-use. The key component of the focal array is the beam-forming network, composed of polarizers, interleaved three-dimensional directional couplers, phase-shifters, and circular feed horns. Design considerations and final simulated radiation patterns are reported for a typical Ka-band multimedia mission.
Recombinant Chicken Interferon from <i>Escherichia coli</i> and Transfected COS Cells is Biologically Active (1995)

We have expressed a cDNA for virus-induced chick interferon in Escherichia coli. The product, a 19-kDa protein lacking the signal peptide, was purified to homogeneity from the bacterial inclusion bodies. Proteins in the insoluble fraction of bacterial lysates were dissolved in guanidine hydrochloride and subjected to chromatography on Q-Sepharose and MonoS columns. Purified recombinant chick interferon has a specific antiviral activity of approximately 10(8) IU/mg and is a powerful inducer of the interferon-responsive promoter of the chicken Mx gene. Culture medium of transfected COS cells expressing full-length chick interferon cDNA contained up to 5 x 10(4) IU antiviral activity/ml that could be neutralized by antibodies to purified recombinant chick interferon. The antibodies precipitated proteins of 23-28 kDa from the supernatants of transfected COS cells. Treatment with endoglycosidase F reduced the size of the immunoprecipitated proteins to approximately 20 kDa, demonstrating that chick interferon is a glycoprotein.