gebhart/patrepeval huggingface dataset:
Thermal lens calorimetry (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleThermal lens calorimetryJ. M. Harris and N. J. DovichiCite this: Anal. Chem. 1980, 52, 6, 695A–706APublication Date (Print):May 1, 1980Publication History Published online21 September 2008Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/ac50056a003https://doi.org/10.1021/ac50056a003research-articleACS PublicationsRequest reuse permissionsArticle Views760Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chemometric Approach to Chiral Recognition Using Molecular Spectroscopy (2009)

Abstract Discrimination of enantiomers by means of a chiral auxiliary can be combined with ordinary molecular spectroscopy and regression modeling to provide a rapid spectroscopic method for the determination of enantiomeric composition of unknown samples. This technique is known as chiral analysis by regression modeling of spectral data (CARMSD). This article describes the basic principles of regression modeling and how regression modeling can be used with ordinary spectroscopic data to produce robust regression models that can predict the enantiomeric composition of unknown samples solely on the basis of their spectral signatures. A major advantage of CARMSD is that prior separation of the enantiomers is not a requirement.
Correspondence of closest gradient Voxels—A robust registration algorithm (1997)

A robust, automatic volume registration algorithm based on intensity gradients is presented. This algorithm can successfully perform registrations under conditions of unrelated intervolume voxel intensities, significant object displacements, and/or significant amounts of missing data. It also allows the user to visualize the registration convergence, clearly illustrating any source of registration errors. This algorithm consists of a matching algorithm based on iteratively finding the correspondence of the closest voxels containing a high three-dimensional intensity gradient magnitude. This algorithm was tested by registering T2-weighted MR volumes that had undergone varying displacement transformations to simultaneously acquired proton-density volumes. These transformations involved rotations of up to 25 degrees followed by translations of up to 25 mm along the axis of rotation. For all registrations, the mean registration error was less than one-fifth of a voxel and the mean registration time was less than 30 minutes. In conclusion, this algorithm is shown to be a powerful method of sequence-independent MR volume registration that is simple to both use and understand.
4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei (2021)

Human African trypanosomiasis is a neglected parasitic disease for which the current treatment options are quite limited. Trypanosomes are not able to synthesize purines de novo and thus solely depend on purine salvage from the host environment. This characteristic makes players of the purine salvage pathway putative drug targets. The activity of known nucleoside analogues such as tubercidin and cordycepin led to the development of a series of C7-substituted nucleoside analogues. Here, we use RNA interference (RNAi) libraries to gain insight into the mode-of-action of these novel nucleoside analogues. Whole-genome RNAi screening revealed the involvement of adenosine kinase and 4E interacting protein into the mode-of-action of certain antitrypanosomal nucleoside analogues. Using RNAi lines and gene-deficient parasites, 4E interacting protein was found to be essential for parasite growth and infectivity in the vertebrate host. The essential nature of this gene product and involvement in the activity of certain nucleoside analogues indicates that it represents a potential novel drug target.
Reliable asymmetric path capacity measurement (2009)

Existing non-cooperative methods for network capacity measurement are quite restrictive for capacity-asymmetric paths, and their results could be affected by adverse network conditions (e.g., packet delay, packet loss, and packet reordering). In this paper, we propose to use two types of packet pairs---round-trip packet pair and two-way packet pair---and the minimum-delay-difference method for reliable capacity measurement. Our preliminary results show that the new proposal is correct and achieves accurate results even for highly capacity-asymmetric paths.
Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications (2017)

The potentially large donor base from caesarean section deliveries, the high yield of term amniotic fluid MSCs obtainable, the properties of the MSCs identified, and the suitability of the cells to be reprogrammed into the pluripotent state demonstrated these cells to be a promising and plentiful resource for further evaluation in bio-banking, cell therapy, disease modelling, and regenerative medicine applications.
Self-calibration from vehicle information (2015)

In this paper, we describe a method to automatically calibrate a static camera using only information regarding the vehicles in the scene. We use standard Adaboost vehicle detection combined with feature-based tracking to determine the size and direction of travel of vehicles at various locations in the scene. We then infer the scene geometry including the height of the camera, the camera focal length, and the angle of the camera with respect to the ground. Given the calibration, we can estimate the size and speed of objects and the distances travelled in the scene. We evaluate our system on 10 cameras with manually annotated calibration based on a 3D cube with user specified locations in 2D. We show our system can be used to accurately estimate vehicle sizes to within 2 feet for a range of camera configurations.
Mechanism of Action of Prostate Stem Cell Antigen Targeted Antibody Therapy and Its Relevance to Clinical Application in Prostate Cancer (2009)

Abstract : We have recently demonstrated that a monoclonal antibody against prostate stem cell antigen (PSCA) can exert anti-tumor activity in a xenograft animal model suggesting oncogenic activity of PSCA in prostate cancer. Therefore the our goal is to elucidate the role of PSCA in the development of prostate cancer. A better understanding of PSCA function and its antibody activity will enable rational patient selection and trial design all of which are particularly relevant to subsequent clinical trials of PSCA antibody. There were difficulties in using the LAPC9 xenograft cells to study the effect of suppressing PSCA but we have since moved ahead to perform an in vivo experiment to study the effect of knocking down PSCA in LAPC9 tumor cells. While the results showed no difference in tumor size we will repeat this experiment this time making sure that PSCA is greatly attenuated before innoculating the tumor cells back into mice. The exciting new data came from the in vitro study of overexpressing PSCA in cell lines. We showed that PSCA promote cell growth in prostate cancer cell line 22RV1 but not in normal cells PZ-HPV7. This results agree with previous data that PSCA is upregulated in prostate cancer. We have also engineered the gene targeting construct to make the human PSCA knockin mice and expect to generate this line in the next 6 month.
Noninvasive Study of the Human Heart using Independent Component Analysis (2006)

We have developed a new approach to studying human heart activity using independent component analysis. The electrocardiogram (ECG) is an important tool in diagnosis of heart disease. However, the normal 12-lead ECG can only record limited aspects of heart's electrical signals and mostly their interpretation relies on trained and experienced medical doctors. We have performed experiments in which heart signals were recorded in high spatial resolution. Independent component analysis was applied to the recorded signals to separate distinct temporal components of the recorded signals. The separated components were further analyzed by back-projecting their activities to the surface montage to examine each component's property. Experimental results show this to be a promising approach that can be extended to build more detailed heart activity simulations
High Performance Elliptic Curve GF(2 m ) Cryptoprocessor Secure Against Timing Attacks (2006)

This paper presents a high performance GF(2m) Elliptic Curve Cryptoprocessor architecture. The proposed cryptoprocessor is based on normal basis representation and uses three multipliers to perform parallel field multiplications. Point operations are performed using Mixed coordinate system to increase the performance and the immunity against timing attacks. The basic idea is to select a combination of point addition and point doubling from Mixed coordinate system such that both point operations requires the same number of multiplication cycles. Thus, an attacker cannot distinguish between point doubling and point addition and therefore it is not possible to extract the key pattern using a timing attack. Results show that the proposed cryptoprocessor gives better time complexity than existing designs which use fake computations by 76%. The proposed cryptoprocessor has been synthesized on a Xilinx Vertex II FPGA (xc2v8000) over GF(2173) and it required 159522 clock cycles to perform scalar multiplication. The proposed cryptoprocessor required 28154 Slices, which is only 60 % out of the total number of available Slices. Key words:
Security Refresh: Protecting Phase-Change Memory against Malicious Wear Out (2010)

As dynamic RAM scaling approaches its physical limit, phase-change memory is the most mature and well-studied option for potential DRAM replacement. However, malicious wear-out attacks can exploit PCM's limited write endurance. To address this, a low-cost wear-leveling scheme can dynamically randomize the data addresses across the entire address space and obfuscate their actual locations from users and system software.
Polarity control in double-gate, gate-all-around vertically stacked silicon nanowire FETs (2012)

We fabricated and characterized new ambipolar silicon nanowire (SiNW) FET transistors featuring two independent gate-all-around electrodes and vertically stacked SiNW channels. One gate electrode enables dynamic configuration of the device polarity (n or p-type), while the other switches on/off the device. Measurement results on silicon show I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> > 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> and S ≈ 64mV/dec (70mV/dec) for p(n)-type operation in the same device. We show that XOR operation is embedded in the device characteristic, and we demonstrate for the first time a fully functional 2-transistor XOR gate.
Development of the New NOx Reduction Catalyst With Hydrocarbons and the Cleanup Systems of Exhaust Gases for Lean-Burn Gas Engines (1999)

Abstract Development of cleanup technology for combustion waste is more and more necessary today. The emissions of stationary natural-gas-fueled engines can be purified by in-engine methods and by treatment of the exhaust gases. This paper describes the latter technologies. There are two conventional technologies for nitrogen oxides (NOx) reduction methods by the three-way catalyst and the selective catalytic reduction (SCR). The three-way catalyst operates only well within a narrow air-to-fuel ratio window, but when the exhaust gas is too lean, the NOx will not be removed. The SCR of NOx in exhaust gas has the advantage that the engine process itself does not have to be adapted and closely controlled as in case of extended lean-burn technologies. Ammonia or urea injected into the exhaust gas must be used as the reducing agent with conventional SCR system. However, the addition of a SCR system for the small or middle size cogeneration system, it would pose problems regarding cost and space for storage and injection of the reducing agent. Therefore, we have examining the catalyst which is able to reduce NOx with hydrocarbons (HC) containing in exhaust gas itself, and we developed the new HC-SCR catalyst. The de-NOx system using the HC-SCR catalyst has numerous advantages as follows: 1) Compactness and low cost: catalyst unit only 2) High efficiency: adaptation of lean-burn technology for engine operation 3) High performance: excellent catalytic activity and durability 4) Safeties: no use of ammonia as a reducing agent In this study, we report the catalytic activity of the new catalyst and propose a total cleanup system for exhaust gases of lean-burn gas engines. Alumina-supported silver (Ag/Al2O3) was used for the new catalyst. When the measurement was carried out with one reducing gas in the reactant gas each, propane and propane were most effective for NOx reduction, ethane and ethylene were secondly effective for NOx reduction. Practical test of the Ag/Al2O3 catalyst was carried out using a real exhaust gas from a 400 kW class lean-bum gas engine. The full-size catalyst was obtained by washcoating the catalyst powder on a metallic monolithic honeycomb substrate (size: 650 mm ϕ × 324 mmL, 200 cells/inch2). When the engine was operated at 400 kWe output, temperature of the exhaust gas was 762 K and GHSV was 17635 h−1. The NOx conversion was reached to 30% and the catalytic activity was maintained after the operation for more than 2000 hr. Conventional alumina-supported platinum (Pt/Al2O3) catalysts were mounted to exhaust gas line for cleanup test. The emission of CO and aldehydes was in the exhaust gas, but it could be highly removed by the Pt/Al2O3 catalyst. Practical tests of this catalyst were carried out using 300–400 kW class lean-burn gas engines. GHSV of these catalysts were about 50,000 h−1. The CO and aldehydes conversion were reached to more than 90% and the catalytic activities were maintained after the operation for about 10,000 hr.
Discovery of <i>N</i>-Isoxazolyl Biphenylsulfonamides as Potent Dual Angiotensin II and Endothelin A Receptor Antagonists (2002)

The ET(A) receptor antagonist (2) (N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)-[1,1'-biphenyl]-2-sulfonamide, BMS-193884) shares the same biphenyl core as a large number of AT(1) receptor antagonists, including irbesartan (3). Thus, it was hypothesized that merging the structural elements of 2 with those of the biphenyl AT(1) antagonists (e.g., irbesartan) would yield a compound with dual activity for both receptors. This strategy led to the design, synthesis, and discovery of (15) (4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-[1,1'-biphenyl]-2-sulfonamide, BMS-248360) as a potent and orally active dual antagonist of both AT(1) and ET(A) receptors. Compound 15 represents a new approach to treating hypertension.
Iodomethane as a methyl bromide alternative for prevention of non-microbial enzyme stain (gray stain) of hardwoods by log fumigation (1997)

Non-microbial discolorations of sapwood in hardwoods causes large economic loss. One method of prevention is to fumigate fresh logs with methyl bromide. Iodomethane has been suggested as a substitute for ozone-depleting methyl bromide in agricultural applications, but its ability to prevent enzyme-mediated stain in wood has not been demonstrated. Sugar hackberry and red oak logs were fumigated under plastic tarps with iodomethane and processed into lumber. Good control of gray stain was noted for hackberry but not for red oak. Iodomethane does kill parenchyma in the sapwood, but is not an adequate substitute for methyl bromide for stain prevention in these hardwoods at similar concentration x time product (CT) values (approximately 18,000 g-hr.). Further trials are needed to determine efficacy of methyl iodide at higher CT values (equivalent molal basis to methyl bromide). Reduction of log fumigation time from 72 to 48 hours with methyl bromide does not provide adequate prevention of sapwood discolorations in these hardwoods.
Dependable virtual machine allocation (2013)

The difficulty in allocating virtual machines (VMs) on servers stems from the requirement that sufficient resources (such as CPU capacity and network bandwidth) must be available for each VM in the event of a failure or maintenance work as well as for temporal fluctuations of resource demands, which often exhibit periodic patterns. We propose a mixed integer programming approach that considers the fluctuations of the resource demands for optimal and dependable allocation of VMs. At the heart of the approach are techniques for optimally partitioning the time-horizon into intervals of variable lengths and for reliably estimating the resource demands in each interval. We show that our new approach allocates VMs successfully in a cloud computing environment in a financial company, where the dependability requirement is strict and there are various types of VMs exist.
Engineering of bone tissue with porcine bone marrow stem cells in three-dimensional trabecular metal: in vitro and in vivo studies. (2003)

The aim of this study was to investigate capability of cell attachment and ectopic bone formation in pigs after either ex vivo transplantation and expansion of bone marrow stem cells (BMSc) into three-dimensional porous tantalum, or porous tantalum supplemented with BMSc. After 24 hours incubation, cells adhering to the porous tantalum discs were quantified by means of scintillation counting of 3H-thymidine-labeled cells. After 7 days of incubation, the cell-loaded porous tantalum discs were harvested for histological analysis or implanted in the infrasternal muscle; an empty disc and disc implanted immediately after cell loading served as controls. All implants were taken out after 8 weeks of implantation and histological examination was performed. The results of in vitro cell attachment to the porous tantalum discs were not improved significantly with gelatin, collagen or fibronectin coatings. Histological analysis of cell loaded discs in vitro demonstrated viable BMSc within the 3-D tantalum structure. In vivo bone induction was demonstrated when the porous tantalum discs were cultured with BMSc. Our findings indicated that porous tantalum was suitable for cell attachment, and ectopic bone formation in pigs was achieved by means of BMSc cultured with porous tantalum. The present study suggests that cell-mediated hard bone tissue repair technology makes it possible to prefabricate autologous BMSc into three-dimensional trabecular metal in order to engineer bone tissue.
Diadenosine and Diuridine Poly(borano)phosphate Analogues:  Synthesis, Chemical and Enzymatic Stability, and Activity at P2Y<sub>1</sub> and P2Y<sub>2</sub> Receptors (2006)

Dinucleoside polyphosphates, NpnN', exert their physiological effects via P2 receptors. They are attractive drug targets as they offer better stability and specificity compared to nucleotides, the most common P2-receptor ligands. To further improve the properties of NpnN', which are still pharmacologically unsatisfactory, we developed novel boranophosphate isosteres of dinucleoside polyphosphates, denoted as Npn(B)N. These analogues were obtained in a facile and efficient synthesis as the exclusive products in a concerted reaction of two nucleoside phosphorimidazolides and inorganic boranophosphate. This unusual reaction is due to the preorganization of three reactant molecules by the Mg2+ ion. We found that Ap3/5(beta/gamma-B)A analogues were potent P2Y1-R agonists. Ap5(gamma-B)A was equipotent to 2-MeS-ADP (EC50 6.3x10(-8) M), thus making it one of the most potent P2Y1-R agonists currently known. Moreover, Ap5(gamma-B)A did not activate P2Y2-R. In contrast, Up3/5(beta/gamma-B)U analogues were extremely poor agonists of both P2Y1-R and P2Y2-R. Npn(B)N analogues exhibited remarkable chemical stability under physiological conditions. Under conditions mimicking gastric juice, Np3(beta-B)N analogues exhibited a half-life (t1/2) of 1.3 h, whereas Np5(gamma-B)N degraded at a much faster rate (t1/2 18 min). The hydrolysis of Ap3(beta-B)A by human nucleotide pyrophosphatase phosphodiesterases (NPP1 and NPP3) was slowed by 40% and 59%, respectively, as compared to Ap3A. However, this effect of the boranophosphate was position-dependent, as Np5(gamma-B)N was degraded at a rate comparable to that of Np5N. In summary, Ap5(gamma-B)A appears to be a highly potent and selective P2Y1-R agonist, as compared to the parent compound. This promising scaffold will be applied in the design of future metabolically stable analogues.
Electrochromism of anodic iridium oxide films on transparent substrates (1978)

Anodic iridium oxide films (AIROF’s) can be grown and operated on transparent substrates. Using SnO2-coated glass as the substrate we can monitor large, rapid, and persistent variations of the light intensity transmitted through the AIROF. The voltammogram of the AIROF on SnO2-coated glass is essentially identical to that of an AIROF on iridium. This proves that the electrochemistry producing the coloration does not involve the substrate.
Study of Regenerable Sorbents for CO2 Capture (2001)

Carbon dioxide (CO2) is a greenhouse gas that is customarily released to the environment during the usage of fossil fuels, including electric power generation. With the projected increase in consumption and demand for fossil fuels, CO2 emissions will correspondingly increase in the absence of any capture/sequestration strategy. In view that CO2 is a greenhouse gas with the
Synchronization performance of the Precision Time Protocol: Effect of clock frequency drift on the line delay computation (2008)

The Precision Time Protocol (PTP) of the IEEE 1588 standard relies on two processes: the timing propagation process and the line delay estimation process. It is important to study the factors that affect the quality of these synchronization sub-processes, in order to expand the limit on the number of slaves synchronizable within a given synchronization precision. This short work-in-progress paper analytically studies the sensitivity of the line delay computation to linear clock frequency drift.
Detection of high-PMD sections along installed fibers by means of a polarization OTDR (2002)

We present the methodology and the results from field measurements along installed fiber links on the localization and classification of fiber sections with respect to their polarization-mode dispersion (PMD) characteristics using a polarization sensitive OTDR (P-OTDR). The technique relies on the statistical analysis of the local degree of polarization (DOP) obtained from the backscattered signal. It allows classifying fiber sections as low-, medium- and high-PMD contributors.
The Brain Injury Biomarker VLP-1 Is Increased in the Cerebrospinal Fluid of Alzheimer Disease Patients (2008)

These results suggest that neuronal injury markers such as VLP-1 may have utility as biomarkers for AD.