gebhart/patrepeval huggingface dataset:
Object Space EWA Surface Splatting: A Hardware Accelerated Approach to High Quality Point Rendering (2002)

Elliptical weighted average (EWA) surface splatting is a technique for high quality rendering of point-sampled 3D objects. EWA surface splatting renders water-tight surfaces of complex point models with high quality, anisotropic texture filtering. In this paper we introduce a new multi-pass approach to perform EWA surface splatting on modern PC graphics hardware, called object space EWA splatting. We derive an object space formulation of the EWA filter, which is amenable for acceleration by conventional triangle-based graphics hardware. We describe how to implement the object space EWA filter using a two pass rendering algorithm. In the first rendering pass, visibility splatting is performed by shifting opaque surfel polygons backward along the viewing rays, while in the second rendering pass view-dependent EWA prefiltering is performed by deforming texture mapped surfel polygons. We use texture mapping and alpha blending to facilitate the splatting process. We implement our algorithm using programmable vertex and pixel shaders, fully exploiting the capabilities of today's graphics processing units (GPUs). Our implementation renders up to 3 million points per second on recent PC graphics hardware, an order of magnitude more than a pure software implementation of screen space EWA surface splatting. Categories and Subject Descriptors (according to ACM CCS): I.3.3 [Computer Graphics]: Display Algorithms
IL-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft vs. host disease (126.31) (2012)

Abstract Intestinal graft vs. host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (allo-BMT). Strategies to limit GVHD by selective promotion of epithelial regeneration in the absence of immunosuppression are largely unknown. We investigated the role of IL-22 in allo-BMT and found that IL-22 levels in small and large intestine were increased after BMT after radiation injury (RI) without BMT. IL-22 upregulation after RI was dependent on the presence of IL-23p40. Although intestinal IL-22 levels were increased after T cell-depleted (TCD) BMT, intestinal IL-22 was reduced by GVHD, as IL-22 production was mediated by host-derived innate lymphoid cells (ILC) that were eliminated by GVHD. Furthermore, host-derived IL-22 was critical for reduction of GVHD morbidity, mortality, and intestinal pathology. GVHD in IL-22 KO mice led to increased apoptosis in epithelial crypts where the intestinal epithelial stem/progenitor cell niche is located. Immunohistochemistry and immunofluorescence demonstrated IL-22 receptor expression on intestinal stem cells (ISC) and progenitors. Allo-BMT in Lgr5-LacZ reporter mice indicated that ISC were targeted by GVHD, and GVHD in IL-22 KO mice led to dramatic ISC depletion. IL-22 is thus critical for protection of host epithelium during GVHD and critical for protection of ISC. These findings may have broad relevance for protection of ISC and intestinal epithelium in clinical GVHD and other inflammatory intestinal diseases.
Dealloyed Nanoporous Metals for PEM Fuel Cell Catalysis (2009)

Although the majority of PEM fuel cell catalysts are made of nanoparticles, similar surface area/volume, specific surface area, and precious metal loading can be made by using ultrathin (~100 nm) nanoporous metal membranes. We discuss here how ultrathin porous membranes can be made using electrochemical dealloying, and how to integrate such membranes into functional fuel cells. Dealloying is the selective dissolution of one or more components from a non-porous precursor alloy. Under the right electrochemical conditions, the remaining alloy component(s) are driven to diffuse along the alloy/electrolyte interface to form a porous metal with pores even smaller than 5 nm. Nanoporous metals can be intrinsically catalytic toward oxygen reduction, or can be coated with thin catalyst layers to form low Pt core-shell catalysts. Using nanoporous metal electrodes for fuel cell catalysis may remove stability issues associated with carbon supports, and opens new avenues for catalyst design.
Design and Implementation of a Tunable, Duffing-Like Electronic Resonator via Nonlinear Feedback (2015)

To date, many vibration-based sensing modalities have relied upon monitoring small shifts in the natural frequency of a system to detect structural changes (e.g., in mass or stiffness), which are attributable to the chemical or biological species, or other phenomena, that are being measured. Often, this approach carries significant signal processing expense due to the presence of electronics, such as precision phase-locked loops, when high sensitivities are required. Bifurcation-based sensing modalities, in contrast, can produce large easy to detect changes in response amplitude with high sensitivity to structural change if applied appropriately. This paper demonstrates the design and implementation of a tunable, Duffing-like electronic resonator realized via nonlinear feedback electronics, which uses a quartz crystal tuning fork as the device platform. The system in this manifestation uses collocated sensing and actuation, along with readily available electronic components, to realize the desired behavior. The sensitivity of the device is tunable via the control of feedback gain and the type of Duffing-like response (hardening or softening) is also selectable, thus creating a versatile bifurcation-based sensing platform.
Novel Insights into Structure–Activity Relationships of N‐Terminally Modified PACE4 Inhibitors (2016)

PACE4 plays important roles in prostate cancer cell proliferation. The inhibition of this enzyme has been shown to slow prostate cancer progression and is emerging as a promising therapeutic strategy. In previous work, we developed a highly potent and selective PACE4 inhibitor, the multi-Leu (ML) peptide, an octapeptide with the sequence Ac-LLLLRVKR-NH2 . Here, with the objective of developing a useful compound for in vivo administration, we investigate the effect of N-terminal modifications. The inhibitory activity, toxicity, stability, and cell penetration properties of the resulting analogues were studied and compared to the unmodified inhibitor. Our results show that the incorporation of a polyethylene glycol (PEG) moiety leads to a loss of antiproliferative activity, whereas the attachment of a lipid chain preserves or improves it. However, the lipidated peptides are significantly more toxic when compared with their unmodified counterparts. Therefore, the best results were achieved not by the N-terminal extension but by the protection of both ends with the d-Leu residue and 4-amidinobenzylamide, which yielded the most stable inhibitor, with an excellent activity and toxicity profile.
Vision-Based Measurement System for Instantaneous Rotational Speed Monitoring Using Linearly Varying-Density Fringe Pattern (2018)

The instantaneous rotational speed (IRS) of a rotating machine is key information to understand the machine operation and diagnose the potential faults. A novel nonprojection fringe vision-based system was proposed to realize the measurement of IRS, which was simply composed of an artificial linearly varying-density fringe pattern (LVD-FP) as a sensor and a high-speed camera as a detector. The designed LVD-FP, printed by a normal printer, was pasted around the surface of the rotary shaft completely along the fringe density change direction. Part of the LVD-FP was captured by the high-speed camera. The fringe period density of each imaged LVD-FP intensity changed due to the rotation of the shaft, from which the rotational angle could be obtained. Subsequently, both the instantaneous angular speed (IAS) between two adjacent frames and the IRS could be accurately and efficiently obtained. The influences of the key parameters of the proposed system on the measurement accuracy were investigated by simulations and experiments. Both the simulation and experimental results demonstrated that the proposed system can accurately measure the IAS and correctly track the wide range IRS with the advantage of noncontact and cost effective. In addition, the rotation direction of the shaft could be directly obtained from the sign of the IRS curves. Therefore, the proposed system could provide a novel vision-based approach for IRS measurement, especially when the conventional speed sensor cannot be installed on the rotary shaft. The good performance of the system in IRS measurement makes it attractive for fault diagnosis of rotating machinery.
Dual-mode dielectric resonator filters with improved spurious performance (2002)

Novel configurations for dual-mode dielectric resonators operating in the HEH/sub 11/ mode or the HEE/sub 11/ mode are presented. The use of the proposed configurations in the design of dual-mode dielectric resonator filters leads to a design with a remarkably improved spurious performance. Techniques to control the frequency separation between the resonance frequencies of the two dual-modes HEH/sub 11/ and HEE/sub 11/ are discussed. Experimental results are presented to verify the validity of the proposed configurations. The proposed configurations promise to be useful in the design of dual-mode dielectric resonator filters for satellite multiplexers having stringent rejection requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Echo-Less Photoconductive Antenna Sources for High-Resolution Terahertz Time-Domain Spectroscopy (2015)

Interdigitated photoconductive antennas are powerful and easy-to-use sources of terahertz radiation for time-resolved spectroscopy. However, the emission of unwanted echoes, resulting from reflections of the emitted pulse in the antenna substrate, inherently limits the spectroscopic frequency resolution. A novel interdigitated photoconductive antenna that suppresses unwanted echoes from the substrate, without power losses, is proposed and demonstrated. This is realized through a buried metal geometry where a metal plane is placed at a sub-wavelength thickness below the surface antenna structure and GaAs active layer. In a reflection geometry this effectively eliminates echoes, permitting high resolution spectroscopy to be performed. As a proof-of-principle, the 1 01 -2 12 and the 2 12 -3 03 rotational lines of water vapor have been spectrally resolved with the new buried metal antenna, which are unresolvable with a standard antenna. In addition, as no THz field is lost to the substrate and reflections, the THz peak electric field amplitude is enhanced by a factor of three compared to a standard design in the equivalent reflection geometry.
Some properties of a continuously adjustable hydrodynamic fluid film bearing (1997)

A novel form of adjustable fluid film bearing has been devised whereby the hydrodynamic conditions can be changed during operation in an externally controlled manner. The principle can be applied to conventionally orientated bearings, i.e. a shaft rotating within the bearing housing; to inverse orientations, i.e. a rotor on a fixed shaft; and to thrust bearings. The embodiments are included in international patent applications filed by British Technology Group Ltd....etc.
Surface enhanced Raman scattering in art and archaeology (2005)

The identification of natural dyes found in archaeological objects and in works of art as textile dyes and lake pigments is a demanding analytical task. To address the problems raised by the very low dye content of dyed fibers and lake pigments, and by the requirement to remove only microscopic samples, surface enhanced Raman scattering techniques were investigated for application to museum objects. SERS gives excellent results with the majority of natural dyes, including: alizarin, purpurin, laccaic acid, carminic acid, kermesic acid, shikonin, juglone, lawsone, brazilin and brazilein, haematoxylin and haematein, fisetin, quercitrin, quercetin, rutin, and morin. In this study, limits of detection were determined for representative dyes and different SERS supports such as citrate reduced Ag colloid and silver nanoisland films. SERS was successfully used to identify natural madder in a microscopic fragment from a severely degraded 11<sup>th</sup> Century Byzantine textile recently excavated in Amorium, Turkey.
Gaucher disease mutations in non‐Jewish patients (1993)

The DNA from 64 non-Jewish patients with Gaucher disease was examined for 29 different glucocerebrosidase mutations that are known to cause the disease. The most common was mutation 1448C and the second most common 1226G. Twenty of the mutations remained unidentified. These results were compared to those obtained from 122 Jewish patients, in whom the most common mutations were 1226G and 84GG. Among the non-Jewish patients 15.6% of the mutations remained unidentified, while among the Jewish patients only 1.2% remained unidentified, and even screening for the five most common mutations identified all but 2.9% of the Jewish mutations. The greater diversity of mutations among the non-Jewish patients has important implications with respect to DNA-based screening, diagnosis and counselling.
Chronic Lymphocytic Leukemia Cells Have Increased Expression of Cyclic Nucleotide Phosphodiesterase 7B, Which May Serve as Disease-Specific Therapeutic Target. (2006)

Abstract Non-specific inhibition of cyclic nucleotide phosphodiesterase (PDE) in chronic lymphocytic leukemia (CLL) cells leads to intracellular accumulation of cyclic nucleotides, which in turn can sensitize the CLL cells to spontaneous and/or drug-induced apoptosis. Recent studies have identified at least 11 isoforms of PDE, each of which catalyzes the hydrolysis of cAMP and/or cGMP and regulates the intracellular levels of cyclic nucleotides. The finding that various tissues differentially express selected PDE isoforms has prompted development of isoform-specific inhibitors that can selectively increase intracellular levels of cyclic nucleotides in target cells that over-express the inhibited PDE isoform. Accordingly, we examined for differential expression of PDE isoforms by CLL B cells by assessing the levels of mRNA encoding each of the 11 different PDE isoforms in CLL cells and normal blood lymphocytes using quantitative real-time RT-PCR. CLL cell samples (n = 24) and lymphocytes of healthy adults (n = 16) each expressed detectable levels of PDE isoforms 1A, 1B, 2A, 3A, 3B, 4A, 4B, 4C, 4D, 5A, 7A, 7B, 8A, 8B, and 9A. However, we discovered that CLL cells of each patient had significantly higher levels of PDE7B mRNA (2.8-fold to 368-fold) and significantly lower levels of PDE3B mRNA (5-fold to 138 fold) than did lymphocytes from healthy donors (n = 16). As such, the ratios of PDE7B/PDE3B in CLL cell samples were >3 (ranging from 3 to 1019), whereas normal lymphocytes had ratios of < 0.3 (ranging from 0.006 to 0.23). The mean PDE7B/PDE3B ratio for CLL cells (123.6 ± 45.0, S.D., n=24) was significantly higher than that for B-lymphocytes of normal donors (3.8 ± 1.1, n=10) (P<0.0001). Immunoblot analyses demonstrated that CLL cells uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. Moreover, we found that PDE7B contributed predominantly to the total PDE activity in CLL cells but not in normal lymphocytes. We thus studied effect of a selective PDE7 inhibitor (BRL-50481) on CLL cells and normal lymphocytes in vitro and found that BRL-50481 dose-dependently promoted apoptosis of CLL cells, but not normal lymphocytes. Collectively these findings indicate that CLL B cells selectively over-express PDE7B and under-express PDE3B relative to normal lymphocytes or isolated blood B cells and suggest that selective inhibitors of PDE7B may be effective in the treatment of this disease.
Step and flash imprint lithography for manufacturing patterned media (2009)

The ever-growing demand for hard drives with greater storage density has motivated a technology shift from continuous magnetic media to patterned media hard disks, which are expected to be implemented in future generations of hard disk drives to provide data storage at densities exceeding 1012 bits per square inch. Step and Flash Imprint Lithography (S-FIL) technology has been employed to pattern the hard disk substrates. This paper discusses the infrastructure required to enable S-FIL in high-volume manufacturing; namely, fabrication of master templates, template replication, high-volume imprinting with precisely controlled residual layers, and dual-sided imprinting. Imprinting of disks is demonstrated with substrate throughput currently as high as 180 disks/hour (dualsided). These processes are applied to patterning hard disk substrates with both discrete tracks and bit-patterned designs.
Estimation of end-expiratory lung volume variations by optoelectronic plethysmography (2001)

OEP measurements of EEVCW accurately reflect the changes of EELV. Furthermore, OEP allows a continuous compartmental analysis, even during unsteady conditions.
Energy efficient transmitters for high bandwidth density links (2022)

Increasing the throughput of a transmitter by scaling out to multiple wavelengths in high bandwidth density links, such as those found in data centers or high performance compute clusters, is beginning to gain traction for two reasons. First, increasing the data rate per wavelength by both increasing the baud rate (>50G) and by increasing the number of bits per symbol (PAM-4) consumes more power and increases latency, from having to use a powerful FEC. Second, a technological advantage, in achieving tight integration of lasers with silicon based photonics, has reduced laser coupling losses and tighter control on laser wavelengths, which in turn allows for greater utilization of the available optical bandwidth. In this talk, we will review our current and past efforts in realizing multi-wavelength laser sources heterogeneously integrated on silicon as a means to generate fully integrated transmitters with bandwidth capacity in excess of 1Tbps over 40 channels. We will also discuss some of the recent results from our MOSCAP microring modulators and Si-Ge/ quantum dot based avalanche photodetectors that enable a fully integrated heater-free compact transceiver. The estimated power consumption for the optical components in such a transmitter is around 1pJ/bit, which is roughly a 10x reduction compared to the state-of-the-art.
Abstract 20873: A Multipotent Cardiovascular Progenitor Population Identified by the SRF Cardiac-Specific Enhancer is Detected Prior to Mesoderm Formation (2010)

Mineral oils are used in substantial quantities for the production of varnishes and inks due to their abundance and versatility. However, as part of the production process, some of mineral oil components are separated as waste material, whereupon they can mix with air, water, or soil and become potentially harmful to the environment. Almost all these waste materials are volatile organic compounds (VOCs), chemicals that can easily evaporate at room temperature and have toxic effect. Therefore, a novel green, mineral oil-free offset printing ink was produced using vegetable oil esters as bio-renewable raw materials. Accompanying varnishes were prepared with linseed oil, methyl oleate, octyl stearate, and four types of resin (A, B, C, and D). The application of these varnishes to magenta color offset ink was subsequently studied to screen out the best combination of resin and ester in terms of setting time. Meanwhile, dyeing force tests were conducted to evaluate the ink's printability, while rheological analysis was done via viscosity and flowability tests. The setting time of the magenta color offset ink made by varnish A was observed to be considerably shorter than that of the ink samples prepared using varnishes B, C, and D. Furthermore, varnish A proved to be a good alternative varnish for the production of yellow, cyan, and black color offset printing inks. Samples of these inks were printed on coated paper, and their printability was contrasted against that of vegetable oil-based (pure vegetable oil), mineral oil-based, and other mineral oil-free offset printing inks. Results determined that the varnishes produced with linseed oil, methyl oleate, and octyl stearate can replace mineral oil-based varnishes for the production of offset printing ink.
Silicon-nitride as a tunnel dielectric for improved SONOS-type flash memory (2003)

High-quality silicon-nitride (Si/sub 3/N/sub 4/) formed by rapid thermal nitridation is investigated as the tunnel dielectric in a SONOS-type memory device for the first time. Compared to a conventional thermal SiO/sub 2/ tunnel dielectric, thermal Si/sub 3/N/sub 4/ provides 100/spl times/ better retention after 1e5 P/E cycles and better endurance characteristics with low programming voltages. Hence, the SONNS structure is promising for nonvolatile memory applications.
Direct detection differential polarization-phase-shift keying based on Jones vector (2004)

In this paper, differential polarization-phase-shift keying (DPolPSK) is proposed for digital lightwave communication, in which information is encoded in both polarization and phase. The DPolPSK symbols are demodulated by optical delayed interference and electrical multilevel detection, without using any polarization control or polarization selection at the receiver. Simulation results show that single-channel error-free transmission at 20 Gb/s (10 Gsymbol/s) through 25 spans of 100 km standard single-mode fiber is possible. The constellation diagram of DPolPSK can be represented by a set of Jones vectors. Hence DPolPSK can also be called differential Jones-vector shift keying (DJSK).
Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS (2016)

Our screening strategy can specifically and effectively identify gRNAs targeting HIV-1 LTR and structural region to excise proviral HIV-1 from the host genome.
Energy Efficient Design in Wireless OFDMA (2008)

Energy-efficient transmission is an important aspect of wireless system design due to limited battery power in mobile devices. We consider uplink energy-efficient transmission in OFDMA systems since mobile stations are battery powered. We account for both circuit and transmit power when designing energy-efficient communication mechanisms and emphasize energy efficiency over peak rates or throughput. Both link adaptation and resource allocation schemes are developed to optimize the overall bits transmitted per Joule of energy, which allows for maximum energy savings in a network. Our simulation results show that the proposed schemes significantly improve energy efficiency.
Optical detection of chemical warfare agents and toxic industrial chemicals (2004)

We present an analytical model evaluating the suitability of optical absorption based spectroscopic techniques for detection of chemical warfare agents (CWAs) and toxic industrial chemicals (TICs) in ambient air. The sensor performance is modeled by simulating absorption spectra of a sample containing both the target and multitude of interfering species as well as an appropriate stochastic noise and determining the target concentrations from the simulated spectra via a least square fit (LSF) algorithm. The distribution of the LSF target concentrations determines the sensor sensitivity, probability of false positives (PFP) and probability of false negatives (PFN). The model was applied to CO<sub>2</sub> laser based photoacosutic (L-PAS) CWA sensor and predicted single digit ppb sensitivity with very low PFP rates in the presence of significant amount of interferences. This approach will be useful for assessing sensor performance by developers and users alike; it also provides methodology for inter-comparison of different sensing technologies.