gebhart/patrepeval huggingface dataset:
Vitamin A Antagonizes Calcium Response to Vitamin D in Man (2001)

For unknown reasons, the highest incidence of osteoporosis is found in northern Europe. In these populations, the sunlight exposure is limited and the vitamin A intake is high. The interaction between vitamin A and D has been the subject of several in vitro and animal studies. We have studied the acute effects of vitamin A and D on calcium homeostasis in 9 healthy human subjects. We compared the effect of (i) 15 mg of retinyl palmitate, (ii) 2 microg of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], (iii) 15 mg of retinyl palmitate plus 2 microg of 1,25(OH)2D3, and (iv) placebo in a double-blind crossover study. The subjects took vitamin preparations at 10:00 p.m. and the following day blood samples were collected five times from 8:00 a.m. to 4:00 p.m. Serum levels of 1,25(OH)2D3 and retinyl esters increased (1.7-fold and 8.3-fold, respectively; p < 0.01). As expected, serum calcium (S-calcium) increased (2.3%; p < 0.01) and S-parathyroid hormone (PTH) decreased (-32%; p < 0.05) after 1,25(OH)2D3 intake. In contrast, retinyl palmitate intake resulted in a significant decrease in S-calcium when taken alone (-1.0%; p < 0.05) and diminished the calcium response to 1,25(OH)2D3 after the combined intake (1.4%; p < 0.01). S-PTH was unaffected by retinyl palmitate. No significant changes in serum levels of the degradation product of C-telopeptide of type I collagen (CrossLaps), or U-calcium/creatinine levels were found. In conclusion, an intake of vitamin A corresponding to about one serving of liver antagonizes the rapid intestinal calcium response to physiological levels of vitamin D in man.
Fixing the train-test resolution discrepancy: FixEfficientNet (2020)

This paper provides an extensive analysis of the performance of the EfficientNet image classifiers with several recent training procedures, in particular one that corrects the discrepancy between train and test images. The resulting network, called FixEfficientNet, significantly outperforms the initial architecture with the same number of parameters. For instance, our FixEfficientNet-B0 trained without additional training data achieves 79.3% top-1 accuracy on ImageNet with 5.3M parameters. This is a +0.5% absolute improvement over the Noisy student EfficientNet-B0 trained with 300M unlabeled images. An EfficientNet-L2 pre-trained with weak supervision on 300M unlabeled images and further optimized with FixRes achieves 88.5% top-1 accuracy (top-5: 98.7%), which establishes the new state of the art for ImageNet with a single crop. These improvements are thoroughly evaluated with cleaner protocols than the one usually employed for Imagenet, and particular we show that our improvement remains in the experimental setting of ImageNet-v2, that is less prone to overfitting, and with ImageNet Real Labels. In both cases we also establish the new state of the art.
Commercialization of low molecular weight guayule rubber in environmentally friendly coatings (1993)

Guayule (Parthenium Argentatum Gray), a shrub growing in the southwest United States and Mexico, is a promising domestic source of natural rubber. Low molecular weight guayule rubber (LMWGR) is one of four major coproducts obtained during the processing of the guayule shrub and this work describes our recent efforts directed to the derivation of value-added LMWGR derivatives; in particular chlorinated hydroxylated LMWGR and acrylated chlorinated LMWGR. Both products are useful as raw materials for the formulation of low volatile organic compound (VOC) coating formulations. Chlorinated hydroxylated LMWGR was synthesized via the chlorination of partially hydroxylated LMWGR whose structure was confirmed by {sup 1}H and {sup 13}C NMR spectroscopy, elemental analysis, and fourier transform infrared spectroscopy (FTIR). We have used chlorinated hydroxylated LMWGR as a reactive, primary alcohol in high solids polyurethane tough, of high gloss, and resistant to water, selected solvents, acids, and bases. Acrylated chlorinated low molecular weight rubber (ACLMWGR) was synthesized via reacting chlorinated hydroxylated LMWGR and acryloyl chloride. ACLMWGR is a useful prepolymer in 100% solids, UV cure coating formulations. The coatings cure readily when exposed to ultraviolet light giving films with excellent adhesion, good chemical resistance, ease of sanding, and water and solvent resistance. The curedmore » finishes are hard, attractive, of high gloss, and possess excellent adhesion as well as superb water and solvent resistance.« less
Neonatal Mice Possessing an Sry Transgene Show a Masculinized Pattern of Progesterone Receptor Expression in the Brain Independent of Sex Chromosome Status (2003)

To assess the relative roles of sex chromosome genes and gonadal steroid hormones in producing sex differences in progesterone receptor (PR) expression in the forebrain of neonatal mice, we used mice in which the Sry gene had been deleted from the Y-chromosome and inserted as a transgene on an autosome in both XX and XY genotypes. Levels of PR immunoreactivity (PRir) in the anteroventral periventricular nucleus, the medial preoptic nucleus, and the ventromedial nucleus were significantly higher in mice that possessed an Sry transgene compared with mice that lacked an Sry transgene, regardless of their complement of sex chromosomes (XX vs. XY). This result suggests that sexual differentiation of PR expression in these regions is likely controlled mainly by gonadal hormones, not by the genetic sex of the brain cells. No differences in PRir were detected between wild-type XY mice with the Sry gene on the Y-chromosome and XY mice with the Sry transgene, suggesting that testicular hormones produced in these two genotypes have comparable effects on neural tissue.
Proliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the<i>rd-1</i>Mouse (2004)

purpose. To establish whether photoreceptor apoptosis in the rd-1 mouse is accompanied by cell cycle progression. Studies of cell cycle proteins in other models of neuronal death provide consistent evidence that a repertoire of proliferative markers accompanies apoptosis. methods. The spatiotemporal progression of photoreceptor loss in rd-1 and control mice at postnatal days (PN)8, -10, -12, -15, and -18 was correlated with markers of G1- and S-phase progression. Photoreceptor death was detected by using morphology and terminal dUTP transferase nick end labeling (TUNEL). Cell-cycle-associated markers consisted of bromodeoxyuridine (BrdU) uptake, and immunolabeling for proliferating cell nuclear antigen (PCNA), Ki-67, and cyclin-dependent kinases-2 and -4. The identity of proliferating cells in the outer nuclear layer was established by double immunolabeling with PCNA and either F4/80 or recoverin. results. A population of proliferating cells in the outer nuclear layer accompanies photoreceptor death along a central to peripheral gradient in rd-1 retinas. Double immunolabeling for PCNA and F4/80 readily identified these as microglial cells originating from the inner retina. Cell cycle progression in photoreceptors could not be demonstrated. conclusions. These findings confirm that in rd-1, a preexisting condition for cell cycle progression does not exist as it does in other neurodegenerative conditions. Therefore, in this model, evidence of photoreceptor cell cycle progression in retinas exposed to neurotrophic factors is likely to result from the therapy itself. In addition, the results confirmed that proliferating microglial cells are intimately associated with the degenerative process in rd-1.
The exploitation of sparse-matrix techniques in conjunction with the piecewise harmonic-balance method for nonlinear microwave circuit analysis (2002)

A novel sparse-matrix approach to the simulation of nonlinear microwave circuits by the Newton-iteration-based piecewise harmonic-balance technique is presented. Selected elements of the Jacobian matrix are set to zero according to some physical criterion, which leads to a sparse Jacobian with a preselected pattern of nonzeros. This allows the use of specialized sparse-matrix solvers, with an effective optimization of both memory storage and CPU time. The code has been developed in both a scalar and a vectorized version optimized for the Cray Y-MP supercomputer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Levels of 2'-deoxycoformycin, adenosine, and deoxyadenosine in patients with acute lymphoblastic leukemia. (1981)

2'-Deoxycoformycin (dCF), a potent inhibitor of adenosine deaminase, has recently undergone Phase I clinical trials and has been found to be therapeutically active in acute lymphoblastic leukemia. In this report, levels of dCF in plasma, plasma concentrations of adenosine and deoxyadenosine, and urine levels of deoxyadenosine were measured in leukemic patients undergoing treatment with dCF during a Phase I clinical trial. dCF was administered i.v. at a dose of 0.25 to 1.0 mg/kg (7.5 to 30 mg/sq m) for 3 consecutive days. Plasma drug levels of 2 to 6 microM were observed following the third dose of dCF, and drug accumulation occurred only at the 1-mg/kg dosage. In this limited series of patients, the plasma concentrations of adenosine and deoxyadenosine and the urine concentrations of deoxyadenosine did not show an obvious correlation with dCF dose, therapeutic response, or toxicity.
Inhibition of human immunodeficiency virus reactivation from latency by a <i>tat</i> transdominant negative mutant (1993)

A BK virus (BKV) expression vector, specific for human cells, was engineered to express antisense human immunodeficiency virus type 1 (HIV-1) tat cDNA (tat-AS) or a tat mutant in cysteine 22 (tat22). Cysteine residues in the cysteine-rich domain of tat are necessary for tat transactivation of the HIV-1 long terminal repeat (LTR). Both the AS tat and the tat mutant significantly inhibited transactivation by tat when assayed in cells cotransfected with an expression vector where the reporter gene for chloramphenicol acetyl transferase was driven by the HIV-1 LTR. Infection of Jurkat cell clones stably expressing tat22 (Jurkat/tat22) or tat-AS (Jurkat/tat-AS) with HIV-1 did not show differences in virus titer in comparison to HIV-1-infected control cells. However, in two Jurkat/tat22 cell clones, entrance of HIV-1 into latency was accelerated significantly and reactivation of HIV-1 from latency induced by tumor necrosis factor-alpha (TNF-alpha) or tat was blocked. These results suggest that, in a combined and integrated approach to the treatment of acquired immunodeficiency syndrome (AIDS), anti-tat genetic therapy could be successfully applied to maintain virus in latency, thereby extending the duration of the asymptomatic phase preceding full-blown AIDS.
Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis (2009)

Abstract The topoisomerase-I (topo-I) inhibitor topotecan, derivative of camptothecin, is the only registered drug for relapsed small cell lung cancer (SCLC). The histone deacetylase inhibitor vorinostat has shown preclinical and clinical antitumor activities in hematologic malignancies and solid tumors, including SCLC, and has recently been approved for the treatment of cutaneous T-cell lymphomas. In this study, we analyzed the antitumor effect of vorinostat combined with topotecan or camptothecin in topo-I inhibitor-sensitive H209 and inhibitor-resistant H526 SCLC cells. Simultaneous or sequential exposure (24 h delay) to either agent resulted in strong synergistic cytotoxic effect in both cell lines, as shown by calculating combination index, and confirmed by growth in soft agar. Combination treatments increased S-phase cell cycle arrest paralleled by apoptosis as measured by hypodiploid peak formation, Annexin V binding, DNA fragmentation, and mitochondria destruction. The apoptotic process was triggered by a caspase-dependent mechanism and can be ascribed to the phosphorylation of H2AX, a reporter of DNA double-strand breaks. These effects were paralleled by an increase of topo-I/DNA covalent complexes induced by combination treatment and suggest a potentiation by vorinostat of topotecan-induced DNA damage. Finally, oxidative injury played a significant functional role in the observed enhanced lethality because coadministration of the antioxidant N-acetyl-l-cysteine blocked reactive oxygen species generation, apoptosis, and mitochondria destruction induced by the vorinostat/topotecan combination. To our knowledge, this is the first demonstration of a synergistic antitumor effect between topotecan and vorinostat in SCLC. Because no well-established treatment is available for recurrent SCLC patients, our results indicate that this drug combination should be explored clinically. [Mol Cancer Ther 2009;8(11):3075–87]
Prenylated Flavonoids from the Roots of<i>Sophora flavescens with</i>Tyrosinase Inhibitory Activity (2003)

Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC 50 = 1.1, 1.3 and 2.1 microM, respectively) than that of kojic acid (IC 50 = 11.3 microM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.
The RESID Database of Protein Modifications: 2003 developments (2003)

The RESID Database is a comprehensive collection of annotations and structures for protein pre-, co- and post-translational modifications including amino-terminal, carboxyl-terminal and peptide chain cross-link modifications. The RESID Database includes: systematic and alternate names, atomic formulas and masses, enzyme activities generating the modifications, keywords, literature citations, Gene Ontology cross-references, Protein Information Resource (PIR) and SWISS-PROT protein sequence database feature table annotations, structure diagrams and molecular models. This database is freely accessible on the Internet through the European Bioinformatics Institute at http://srs.ebi.ac.uk/srs6bin/cgi-bin/wgetz?-page+LibInfo+-lib+RESID, through the National Cancer Institute - Frederick Advanced Biomedical Computing Center at http://www.ncifcrf.gov/RESID, or through the Protein Information Resource at http://pir.georgetown.edu/pirwww/dbinfo/resid.html.
Cyclodehydration of diols catalyzed by CpxMCl4-x (x = 0-2; M = Ti, Zr, Hf) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclodehydration of diols catalyzed by CpxMCl4-x (x = 0-2; M = Ti, Zr, Hf)Anil Wali, Pralhad A. Ganeshpure, S. Muthukumaru Pillai, and Sheo SatishCite this: Ind. Eng. Chem. Res. 1994, 33, 2, 444–447Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ie00026a042https://doi.org/10.1021/ie00026a042research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Role of Experiments for the Development of Economic Theories (2009)

Abstract: Economic experiments interact with economic theories in various ways. First of all they are used to test economic theories. However, they can neither confirm nor falsify them in a strict sense. They rather inform us about the range of applicability, the robustness and the predictive power of a theory. Furthermore, economic experiments discover and isolate phenomena and challenge economic theorists to explain them. Finally, many economic experiments are “material” models. They are used to analyze and predict how changes in the environment affect economic outcomes. However, they cannot offer an explanation for what we observe. This has to be provided by economic theory.
High speed piezoresponse force microscopy: &lt;1 frame per second nanoscale imaging (2008)

An atomic force microscopy (AFM) based technique is described for mapping piezoactuation with nanoscale resolution in less than a second per complete image frame. “High speed piezo force microscopy” (HSPFM) achieves this &gt;100× increase in acquisition rates by coupling a commercial AFM with concepts of acoustics. This allows previously inaccessible dynamic studies, including measuring ferroelectric domain nucleation and growth during in situ poling. Hundreds of consecutive images are analyzed with 49 μs temporal resolution per pixel per frame, revealing 32 nucleation sites/μm2 with 36 μm/s average domain velocities. HSPFM images acquired in as fast as 1/10th s are also presented.
International dissemination of epidemic Vibrio cholerae by cargo ship ballast and other nonpotable waters (1994)

In 1991 and 1992, toxigenic Vibrio cholerae O1, serotype Inaba, biotype El Tor, was recovered from nonpotable (ballast, bilge, and sewage) water from five cargo ships docked in ports of the U.S. Gulf of Mexico. Four of these ships had taken on ballast water in cholera-infected countries; the fifth took on ballast in a noninfected country. Isolates examined by pulsed-field gel electrophoresis were indistinguishable from the Latin American epidemic strain, C6707; however, they differed significantly from the endemic Gulf Coast strain (VRL 1984), the sixth-pandemic strain (569-B), and a V. cholerae non-O1 strain isolated from a ship arriving from a foreign port. On the basis of our findings, the Food and Drug Administration recommended that the U.S. Coast Guard issue an advisory to shipping agents and captains requesting that ballast waters be exchanged on the high seas before entry of ships into U.S. ports.
Inter‐ and intramolecular interactions in polyelectrolyte complex formation with polyampholytes (1993)

Abstract Employing polyampholytes (inclusively polybetaines) of different chemical structure containing carboxylic groups and various basic nitrogen functions, homosymplex formation, as well as the competition between homo‐ and heterosymplex formation on addition of an appropriate polyelectrolyte, was investigated in dependence of pH and ionic strength by means of viscometry and turbidimetry. With most, but not with all, of the polyampholytes, the expected viscosity minimum at the isoelectric point, with its steepness depending on polyampholyte structure, was observed. Competition of homo‐ and heterosymplex formation at and near the isoelectric point is mainly governed by the p K values of the species involved, the level of zwitter‐ion formation of the polyampholyte and the effect of non‐Coulombic interactions, for example, via hydrogen bonds.
Design, Synthesis, and Biological Activity of Novel Myricetin Derivatives Containing Amide, Thioether, and 1,3,4-Thiadiazole Moieties (2018)

A series of myricetin derivatives containing amide, thioether, and 1,3,4-thiadiazole moieties were designed and synthesized, and their antiviral and antibacterial activities were assessed. The bioassays showed that all the title compounds exhibited potent in vitro antibacterial activities against <i>Xanthomonas citri</i> (<i>Xac</i>), <i>Ralstonia solanacearum</i> (<i>Rs</i>), and <i>Xanthomonas oryzae pv. Oryzae</i> (<i>Xoo</i>). In particular, the compounds <b>5a</b>, <b>5f</b>, <b>5g</b>, <b>5h</b>, <b>5i,</b> and <b>5l</b>, with EC<sub>50</sub> values of 11.5⁻27.3 μg/mL, showed potent antibacterial activity against <i>Xac</i> that was better than the commercial bactericides Bismerthiazol (34.7 μg/mL) and Thiodiazole copper (41.1% μg/mL). Moreover, the in vivo antiviral activities against tobacco mosaic virus (TMV) of the target compounds were also tested. Among these compounds, the curative, protection, and inactivation activities of <b>5g</b> were 49.9, 52.9, and 73.3%, respectively, which were better than that of the commercial antiviral Ribavirin (40.6, 51.1, and 71.1%, respectively). This study demonstrates that myricetin derivatives bearing amide, thioether, and 1,3,4-thiadiazole moieties can serve as potential alternative templates for the development of novel, highly efficient inhibitors against plant pathogenic bacteria and viruses.
Build your world and play in it: Interacting with surface particles on complex objects (2010)

We explore interacting with everyday objects by representing content as interactive surface particles. Users can build their own physical world, map virtual content onto their physical construction and play directly with the surface using a stylus. A surface particle representation allows programmed content to be created independent of the display object and to be reused on many surfaces. We demonstrated this idea through a projector-camera system that acquires the object geometry and enables direct interaction through an IR tracked stylus. We present three motivating example applications, each displayed on three example surfaces. We discuss a set of interaction techniques that show possible avenues for structuring interaction on complicated everyday objects, such as Surface Adaptive GUIs for menu selection. Through a preliminary informal evaluation and interviews with end users, we demonstrate the potential of interacting with surface particles and identify improvements necessary to make this interaction practical on everyday surfaces.
The role of caspase-3 in lipopolysaccharide-mediated disruption of intestinal epithelial tight junctions (2006)

The mechanisms responsible for microbially induced epithelial apoptosis and increased intestinal permeability remain unclear. This study assessed whether purified bacterial lipopolysaccharide (LPS) increases epithelial apoptosis and permeability and whether these changes are dependent on caspase-3 activation. In nontumorigenic epithelial monolayers, Escherichia coli O26:B6 LPS increased apoptosis, as shown by nuclear breakdown, caspase-3 activation, and PARP cleavage, and induced disruption of tight junctional ZO-1. Apical, but not basolateral, exposure to LPS increased epithelial permeability. Addition of a caspase-3 inhibitor abolished the effects of LPS. The findings describe a novel mechanism whereby apical LPS may disrupt epithelial tight junctional ZO-1 and barrier function in a caspase-3-dependent fashion.
Monitoring regionaler Immobilienpreise 2016: Gefahr einer Überhitzung am Häusermarkt gestiegen (2016)

In den vergangenen Monaten haben die Immobilienpreise in Deutschland deutlich angezogen. Da Einkommensperspektiven eine wichtige Determinante von Immobilienpreisen sind, untersuchen wir die, um Veränderungen der Objektqualität bereinigte, regionale Preisentwicklung auf der Ebene der Arbeitsmarktregionen. Neben der Darstellung der regionalen Preisentwicklung untersuchen wir die Preisprozesse der realen Wohnungs- und Häuserpreise. Diese Analyse legt insbesondere für Häuserpreise nicht nachhaltige Entwicklungen in einer Vielzahl der betrachteten Arbeitsmarktregionen nahe.