gebhart/patrepeval huggingface dataset:
Diet-Induced Increases in Adiposity, but Not Plasma Lipids, Promote Macrophage Infiltration Into White Adipose Tissue (2007)

Obesity, hyperlipidemia, and insulin resistance are cardinal features of the metabolic syndrome and individually increase the risk for developing diabetes and cardiovascular disease, a risk that is amplified when they are simultaneously present. It is becoming increasingly clear that macrophages can infiltrate white adipose tissue (WAT) in the obese state, and their presence is associated with pathophysiological consequences of obesity, such as inflammation and insulin resistance. To determine whether hyperlipidemia could potentiate macrophage infiltration into WAT in the presence of obesity, obesity-prone agouti yellow mice (A(y)/a) on a hyperlipidemia-prone LDL receptor (LDLR)-deficient (LDLR(-/-)) background were placed on chow or Western diet. In addition, A(y)/a mice that were LDLR sufficient were also placed on Western diet. Both genetics and diet increased the degree of adiposity; however, plasma lipids were elevated only in the Western diet-fed LDLR(-/-) mice. The extent of macrophage accumulation in WAT correlated with the degree of adiposity. However, hyperlipidemia did not impact macrophage recruitment to WAT or the downstream metabolic consequences of macrophage accumulation in WAT, such as inflammation and insulin resistance. These data have important implications for the pathogenesis of diet-induced obesity in humans, even when plasma lipid abnormalities are not present.
Single Crystal Growth, Optical Properties and Neutron Response of ${\rm Ce}^{3+}$ Doped ${\rm LiCaAlF}_{6}$ (2009)

Ce2%: <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiCaAlF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> ( <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiCAF) single crystal (nominal composition) with 2 mm in diameter and 50 mm in length was grown by the micro-pulling-down method. Emission from the perturbed Ce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> centers was observed in an ¿-ray excited radioluminescence. The neutron response was compared with Li-glass (GS20, Saint-Gobain) using <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">252</sup> Cf. The scintillation decay time of Ce2%: <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiCAF is 38 nsec, which is twice as short as that of GS20. Using Hamamatsu photomultiplier H7416 the photoelectron yield about a half of that of GS20 has been measured for the Ce: <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiCAF single crystal . Considering the light yield of GS20 (6000 phot/neutron) and the spectral correction due to the different emission peak position in both materials, the light yield of Ce: <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiCAF single crystal is estimated about 4200 phot/neutron.
NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes (2011)

NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair. In this work, we dissected distinct DNA double-strand break (DSB) repair mechanisms revealing a stimulatory role of NF-κB in homologous recombination (HR). This effect was independent of chromatin context, cell cycle distribution or cross-talk with p53. It was not mediated by the transcriptional NF-κB targets Bcl2, BAX or Ku70, known for their dual roles in apoptosis and DSB repair. A contribution by Bcl-xL was abrogated when caspases were inhibited. Notably, HR induction by NF-κB required the targets ATM and BRCA2. Additionally, we provide evidence that NF-κB interacts with CtIP-BRCA1 complexes and promotes BRCA1 stabilization, and thereby contributes to HR induction. Immunofluorescence analysis revealed accelerated formation of replication protein A (RPA) and Rad51 foci upon NF-κB activation indicating HR stimulation through DSB resection by the interacting CtIP-BRCA1 complex and Rad51 filament formation. Taken together, these results define multiple NF-κB-dependent mechanisms regulating HR induction, and thereby providing a novel intriguing explanation for both NF-κB-mediated resistance to chemo- and radiotherapies as well as for the sensitization by pharmaceutical intervention of NF-κB activation.
Silicon atomic layer growth controlled by flash heating in chemical vapor deposition using SiH4 gas (1993)

The separation between surface adsorption and reaction of SiH4 on a Si substrate has been investigated by heating the surface with a Xe flash lamp in an ultraclean low-pressure environment. About 0.4 atomic-layer epitaxy per flash-lamp light shot was observed on Si(100) at a substrate temperature of 385 °C and at SiH4 partial pressure of 500 Pa. The dependencies of SiH4 surface coverage on the SiH4 partial pressure and shot-to-shot time interval are expressed by the Langmuir adsorption type equation, assuming that the total adsorption site density is equal to the surface atom density.
Transport protocol for smart grid infrastructure (2010)

There is an emerging class of applications in which there is a need to reliably transport data from a large number of low rate devices (e.g., hundreds of thousands) to a central server. Atop the list of such applications is smart grid infrastructure. Other applications include meteorological applications, such as monitoring of weather, pollution, and allergy conditions. These applications are characterized by the existence of a large number of small Internet Protocol (IP) devices sending small packets at a low rate to the same server. Even though individual data rates are low, aggregation of these rates produce a significant amount of traffic that can disrupt the communication function of other applications. Because individual devices produce data at a low rate, the transmission control protocol's (TCP) congestion control mechanism is rendered ineffective, thereby causing (i) excessive retransmission of packets; and (ii) degrading the throughput of other competing applications. To address the above problems, we introduce the concept of aggregation at the communication transport level. A TCP aggregator node is added between the data sources and the central server. It splits the TCP connections between the sources (e.g., smart meters) and the data collection server. The aggregator collects data from the individual sources and reliably forwards the data to the collection server. The new strategy provides better response to traffic conditions and, most importantly, makes congestion control and flow control useful. Through extensive NS-2 simulations, we show the effectiveness of the TCP aggregator approach to mitigating the problems in terms of the throughput and packet drop rate performance metrics.
Artificial neural network using thin-film transistors - Working confirmation of asymmetric circuit - (2013)

We are developing neural networks of device level using thin-film transistors (TFT). By adopting an interconnect-type neural network and utilizing a characteristic shift of poly-Si TFTs as a variable strength of synapse connection, which was originally an issue, we realized the neuron consisting of eight TFTs and synapse of only one TFT. Particularly in this presentation, we confirmed the working by a circuit where the input and output elements are asymmetric. This is a result leading to a super-large, self-learning, and high-flexibility system.
The 19-kDa glycoprotein coded by region E3 of adenovirus. Purification, characterization, and structural analysis. (1985)

A prominent glycoprotein is induced during early stages of infection by human adenoviruses (Ads') (1-4).
Geodesic Convolutional Shape Optimization (2018)

Aerodynamic shape optimization has many industrial applications. Existing methods, however, are so computationally demanding that typical engineering practices are to either simply try a limited number of hand-designed shapes or restrict oneself to shapes that can be parameterized using only few degrees of freedom. In this work, we introduce a new way to optimize complex shapes fast and accurately. To this end, we train Geodesic Convolutional Neural Networks to emulate a fluidynamics simulator. The key to making this approach practical is remeshing the original shape using a polycube map, which makes it possible to perform the computations on GPUs instead of CPUs. The neural net is then used to formulate an objective function that is differentiable with respect to the shape parameters, which can then be optimized using a gradient-based technique. This outperforms state- of-the-art methods by 5 to 20% for standard problems and, even more importantly, our approach applies to cases that previous methods cannot handle.
Triple-negative breast cancer tumors in Peruvian patients: Worst prognostic to reach surgery after standard neoadjuvant chemotherapy. (2010)

e11020 Background: Triple-negative breast cancer is an aggressive disease with poor clinical outcomes. This breast cancer subtype is negative for ER/PR receptors and HER2 protein and is managed with standard chemotherapy (CT) as anthracycline and/or taxane-based CT. The study aim is to evaluate the probability of surgery resectability after neoadjuvant CT in triple-negative vs. non-triple-negative breast cancer tumors. Methods: 116 II-III stage breast cancer pts were included in a randomized study for FAC vs. paclitaxel/FAC as a neoadjuvant CT at INEN - Perú. CT was 6 FAC cycles vs. 12 week paclitaxel followed by 4 FAC cycles. Clinical evaluations were performed at every visit. Results: 116 pts registered and 110 pts eligible and analyzable, 54 to FAC and 56 to paclitaxel/FAC. Treatment groups were balanced for age, ER, PR, HER2 and baseline tumor size. Most of the patients were III-B stage in both groups. Mean age in years by FAC 48.7 and by paclitaxel/FAC 49.9. Mean baseline tumor size in cm. by FAC 9.62 and by paclitaxel/FAC 9.10. Univariate analysis show 41 (52.6%) pts with FAC have reached surgery vs. 37 (47.4%) with paclitaxel/FAC (p = 0.48). In both treatment groups by IHC markers, pts have reached surgery were 26 (33.3%) ER negative vs. 52 (66.7%) ER positive (p < 0.05), 38 (48.7%) PR negative vs. 40 (51.3%) PR positive (p < 0.05) and 65 (83.3%) HER2 negative vs. 13 (16.7 %) HER2 positive (p = 0.55). Multivariate analysis shows the probability of reaching surgery with paclitaxel/FAC trend to be lower than FAC (OR = 0.76 – 95%CI: 0.29 -1.95). In both treatment groups by IHC markers, ER positive have 4 times more chances to reach surgery than ER negative (OR = 4.36 – 95%CI: 1.04–18.33), PR positive and HER2-positive trends to have more chances to reach surgery than ER negative and HER2 negative, but are not significant. Finally, the probability of reaching surgery with standard neoadjuvant CT (FAC and paclitaxel/FAC) is 6 times more in breast cancer tumors non-triple-negative vs. triple-negative (OR = 6.36 – 95%CI: 2.48–16.33). Conclusions: Triple-negative breast cancer tumors seem to not reach surgery resectability vs non-triple-negative tumors after standard neoadjuvant CT anthracycline or anthracycline/taxane-based CT. No significant financial relationships to disclose.
P11467: An Orally-Active Acetylcholinesterase Inhibitor and α2-Adrenoceptor Antagonist for Alzheimer’s Disease (1997)

Alzheimer’s disease (AD) is a complex and multifaceted neurodegenerative disease characterized by cognitive and behavioral abnormalities. The primary cognitive deficit has been correlated with extensive cholinergic dysfunction and the efficacy of cholinergic therapies in this disease validates and supports the cholinergic hypothesis of AD (Weinstock, 1995). To date, tacrine has shown clinical efficacy in 20 to 30% of AD patients and remains the only acetylcholinesterase inhibitor (AChEI) to receive FDA approval for symptomatic treatment (Knapp et al., 1994). However, the limited efficacy of pure cholinergic therapies suggests that other neurochemical deficiencies are involved.
Novel cell-AGC technique for burst-mode CMOS preamplifier with wide dynamic range and high sensitivity for ATM-PON system (2002)

We propose a novel cell-AGC technique for an ATM-cell-based burst optical receiver on a 156-Mb/s subscriber system. The cell-AGC controls transimpedance gain according to the burst-cell power and enables reception of burst signals with low extinction ratio. In addition, to realize high sensitivity, we developed an amplifier that is stable under changes in ambient conditions and deviations of transistor characteristics on IC. By adopting these techniques in a CMOS preamplifier IC, the detectable power difference between burst cells was enlarged to more than 30 dB, and the minimum sensitivity was improved to less than -39.3 dBm. These performances show that our new IC fully satisfies the high-sensitivity specification of an ATM-PON system, and incorporating this IC in the system makes it more flexible and economical.
Human respiratory epithelial cells derived from the nasal turbinate express mesenchymal stem cell markers (2011)

To our knowledge, this is the first time that antibody fragments with intact Fc-region of immunoglobulin have been produced in L. tarentolae. Using the plasmid pMJ_LEXSY-rFc, L. tarentolae T7-TR can be applied as an efficient tool for expression of rFc fusion antibody fragments, allowing easy purification from the growth medium. This system provides an alternative in cases where antibody constructs express poorly in standard prokaryotic systems. Furthermore, in cases where bivalent Fc-fused antibody constructs are needed, using L. tarentolae for expression provides an efficient alternative to mammalian expression.
Learning to Traverse Image Manifolds (2007)

We present a new algorithm, Locally Smooth Manifold Learning (LSML), that learns a warping function from a point on an manifold to its neighbors.Important characteristics of LSML include the ability to recover the structure of the manifold in sparsely populated regions and beyond the support of the provided data.Applications of our proposed technique include embedding with a natural out-of-sample extension and tasks such as tangent distance estimation, frame rate up-conversion, video compression and motion transfer.
Cannabis and anxiety: a critical review of the evidence (2009)

The precise relationship between cannabis use and anxiety has yet to be established. Research is needed to fully clarify the mechanisms of such the association.
REVIEW ARTICLE: Tolerance to the Foetal Allograft? (2010)

In this review, we will detail the concept of tolerance and its history in reproductive immunology. We will then consider whether it applies to the foetal-maternal relationship and discuss the mechanisms involved in non-rejection of the foeto-placental unit.
An intermediate representation for behavioral synthesis (1990)

This paper describes an intermediate representation for behavioral and structural designs that is based on annotated state tables. It facilitates user control of the synthesis process by allowing specification of partially design structures, and a mixture of behavior, structure and user specified bindings between the abstract behavior and the structure. The format's general model allows the capture of synchronous and asynchronous behavior, and permits hierarchical descriptions with concurrency. The format is easily translated to VHDL for simulation at each stage of the design process. It therefore complements a good simulation language (VHDL) by providing an excellent input path for behavioral and register-transfer synthesis. The format's simple and uniform syntax allows it to be used both as an intermediate exchange format for various behavioral synthesis tools, and as a graphical tabular interface for the user, thereby allowing a natural medium for automatic or manual refinement of the design.
Demonstration of a pseudo-magnetization based simultaneous write and read operation in a Co60Fe20B20/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 heterostructure (2020)

Taking advantage of the magnetoelectric and its inverse effect, this article demonstrates strain-mediated magnetoelectric write and read operations simultaneously in Co<sub>60</sub>Fe<sub>20</sub>B<sub>20</sub>/Pb(Mg<sub>1/3</sub>Nb<sub>2/3</sub>)<sub>0.7</sub>Ti<sub>0.3</sub>O<sub>3</sub> heterostructures based on a pseudo-magnetization µ ≡ m<sub>x</sub><sup>2 </sup>- m<sub>y</sub><sup>2</sup>. By applying an external DC-voltage across a (011)-cut PMN-PT substrate, the ferroelectric polarization is re-oriented, which results in an anisotropic in-plane strain that transfers to the CoFeB thin film and changes its magnetic anisotropy H<sub>k</sub>. The change in H<sub>k</sub> in-turn results in a 90° rotation of the magnetic easy axis for sufficiently high voltages. Simultaneously, the inverse effect is employed to read changes of the magnetic properties. The change of magnetization in ferromagnetic (FM) layer induces an elastic stress in the piezoelectric (PE) layer, which generates a PE potential that can be used to readout the magnetic state of the FM layer. The experimental results are in excellent qualitative agreement with an equivalent circuit model that considers how magnetic properties are electrically controlled in such a PE/FM heterostructure and how a back-voltage is generated due to changing magnetic properties in a self-consistent model. We demonstrated that a change of easy axis of magnetization due to an applied voltage can be directly used for information processing, which is essential for future ME based devices.
Three-carrier 1 Tbit/s Dual Polarization 16-QAM Superchannel Using Look-Up Table Correction and Optical Pulse Shaping (2013)

By using look-up table correction for pattern-dependent distortion and optical pulse shaping for enhancing the spectral efficiency, a three-carrier 1.206 Tbit/s dual-polarization 16-QAM superchannel exhibits a back-to-back OSNR sensitivity of 25.9 dB (BER = 10-3), a net spectral efficiency of 4.47 b/s/Hz, and transmission over 1500 km of SMF.
Simple ps microchip Nd:YVO<sub>4</sub>laser with 3.3-ps pulses at 0.2 to 1.4 MHz and single-stage amplification to the microjoule level (2016)

Commercial picosecond sources have found widespread applications. Typical system parameters are pulse widths below 20 ps, repetition rates between 0.1 and 2 MHz, and microjoule level pulse energies. Most systems are based on short pulse mode-locked oscillators, regenerative amplifiers, and pockel cells as active beam switches. In contrast, we present a completely passive system, consisting of a passively Q-switched microchip laser, a single-stage amplifier, and a pulse compressor. The Q-switched microchip laser has a 50-μm-long Nd:YVO4 gain material optically bonded to a 4.6-mm-thick undoped YVO4 crystal. It delivers pulse widths of 40 ps and repetition rates of 0.2 to 1.4 MHz at a wavelength of 1.064 μm. The pulse energy is a few nanojoule. These 40-ps pulses are spectrally broadened in a standard single-mode fiber and then compressed in a 24-mm-long chirped Bragg grating to as low as 3.3 ps. The repetition rate can be tuned from ∼0.2 to 1.4 MHz by changing the pump power, while the pulse width and the pulse energy from the microchip laser are unchanged. The spectral broadening in the fiber is observed throughout the pulse repetition rate, supporting sub-10-ps pulses. Finally, the pulses are amplified in a single-stage Nd:YVO4 amplifier up to the microjoule level (up to 4 μJ pulse energy). As a result, the system delivers sub-10-ps pulses at a microjoule level with about 1 MHz repetition rate, and thus fulfills the requirements for ps-micromachining. It does not contain any active switching elements and can be integrated in a very compact setup.
Nano-vibration effect on cell adhesion and its shape (2011)

Extracellular physical features of underlying the adhesive substrate affect cell adhesion to it substrate. In this study, the effects of vibration, a type of artificial physical stimulation, on the adhesion of mouse L929 cells, mouse embryonic fibroblasts (MEFs), HeLa cells and human umbilical vein endothelial cells (HUVECs) are reported. A nano-vibration system was designed to produce nanometer-scale vibration. When L929 cells, HeLa cells, and HUVECs were subjected to vibration at 100 Hz and 1 kHz, they were not affected. On the other hand, in MEFs, the adherent cells were increased and changed their shape remarkably in response to 1 kHz vibration. To investigate the MEFs' sensitivity to vibration in detail, the cells shape was classified into four types; round, stellate, filopodia-formed and lamellipodia-formed. In serum addition culture, 1 kHz vibration increased the number of filopodia-formed cells but decreased lamellipodia cells. Furthermore, the preliminary cDNA microarray experiments showed that expression of genes which regulate cytoskeleton were changed by vibration stimulation. These results suggest that vibration could affect cell adhesion and the determination cell shape.
Interactive digital inverse filtering and its relation to linear prediction methods (2005)

This paper is concerned with inverse filtering of the speech waveform in order to study the details of vocal tract excitation. An interactive digital inverse filtering system is described in which the advantages of previously described analogue and digital methods are combined to provide a facility with much greater convenience and power than either. Experience with this system is compared with that obtained using closed-period covariance-method linear prediction analysis. Evidence is presented to support the contention that since there is continued activity in the closed-glottis period there are definite advantages in having an interactive capability.
Achieving better outcomes for Chinese law students studying overseas (2016)

The internationalization of tertiary education has resulted in an influx of Chinese students studying in Australia. This movement brings invaluable advantages to Chinese law students studying overseas as well as challenges to host universities and their teaching staff. Much of these relate to social, cultural and educational differences, which have not been adequately acknowledged by the current teaching methodologies of host university law schools.\nThis article discusses the main difficulties experienced by Chinese law students and the main efforts that have been made to help them overcome their difficulties. Although efforts to improve the situation have been made by host and home institutions through support programs and adjustments in teaching methodologies, the challenges experienced by Chinese law students persist. This article therefore recommends new approaches that may help Chinese students achieve better learning outcomes overseas.
Low‐Power Flexible Organic Light‐Emitting Diode Display Device (2011)

A low-power flexible organic light-emitting diode (OLED) display device based on low temperature color filters with a thin film encapsulated RGB OLED microcavity is achieved with high contrast ratios (up to 150 000:1 in dark ambient) and low power consumption (34% power saving compared to polarization film). Furthermore, a mechanical 10 000 times folding experiment with a folding radius of 1 mm demonstrates the mechanical reliability of the flexible OLED device.