gebhart/patrepeval huggingface dataset:
Evaluation of flat panel detector cone beam CT breast imaging with different sizes of breast phantoms (2005)

The sensitivity to detect small breast cancers and the specificity of conventional mammography (CM) remain limited owing to an overlap in the appearances of lesions and surrounding structure. We propose to address the limitations accompanying CM using flat panel detector (FPD)-based cone beam CT breast imaging (CBCTBI). The purpose of the study is to determine optimal x-ray operation ranges for different sizes of normal breasts and corresponding glandular dose levels. The current CBCT prototype consists of a modified GE HighSpeed Advantage CT gantry, an x-ray tube, a Varian PaxScan 4030CB FPD, a CT table and a PC. Two uncompressed breast phantoms, with the diameters of 10.8 and 13.8 cm, consist of three inserts: a layer of silicone jell simulating a background structure, a lucite plate on which five simulated carcinomas are mounted, and a plate on which six calcifications are attached. With a single scan, 300 projections were acquired for all phantom scans. The optimal x-ray techniques for different phantom sizes were determined. The total mean glandular doses for different size phantoms were measured using a CT pencil ionization chamber. With the optimal x-ray techniques that result in the maximal dose efficiency for the different tissue thickness, the image quality with two different phantoms was evaluated. The results demonstrate that the CBCTBI can detect a few millimeter-size simulated carcinoma and ~ 0.2 mm calcification with clinically acceptable mean glandular doses for different size breasts.
High-dimensional modulation for coherent optical communications systems (2014)

In this paper, we examine the performance of several modulation formats in more than four dimensions for coherent optical communications systems. We compare two high-dimensional modulation design methodologies based on spherical cutting of lattices and block coding of a 'base constellation' of binary phase shift keying (BPSK) on each dimension. The performances of modulation formats generated with these methodologies is analyzed in the asymptotic signal-to-noise ratio regime and for an additive white Gaussian noise (AWGN) channel. We then study the application of both types of high-dimensional modulation formats to standard single-mode fiber (SSMF) transmission systems. For modulation with spectral efficiencies comparable to dual-polarization (DP-) BPSK, polarization-switched quaternary phase shift keying (PS-QPSK) and DP-QPSK, we demonstrate SNR gains of up to 3 dB, 0.9 dB and 1 dB respectively, at a BER of 10(-3).
Quick application/release nut with engagement indicator (commercial application of an innovative nut design) (1991)

This is an assembly which permits a fastener to be inserted or removed from either side with an indicator of fastener engagement. The nut has a plurality of segments, preferably at least three segments, which are internally threaded, spring loaded apart by an internal spring, and has detents on opposite sides which force the nut segments into operative engagement with a threaded member when pushed in and release the segments for quick insertion or removal of the fastener when moved out. When the nut is installed, end pressure on the detents presses the nut segments into operative engagement with a threaded member where continued rotation locks the structure together with the detents depressed to indicate positive locking engagement of the nut. On removal, counterclockwise rotation relieves the endwise pressure on the detents, permitting internal springs to force the detents outward, allowing the nut segments to move outward and separate to permit quick removal of the fastener.
The clinical use of blood-test factors for Alzheimer’s disease: improving the prediction of cerebral amyloid deposition by the QPLEXTM Alz plus assay kit (2021)

Alzheimer's disease (AD) is the leading cause of dementia, and many studies have focused on finding effective blood biomarkers for the accurate diagnosis of this disease. Predicting cerebral amyloid deposition is considered the key for AD diagnosis because a cerebral amyloid deposition is the hallmark of AD pathogenesis. Previously, blood biomarkers were discovered to predict cerebral amyloid deposition, and further efforts have been made to increase their sensitivity and specificity. In this study, we analyzed blood-test factors (BTFs) that can be commonly measured in medical health check-ups from 149 participants with cognitively normal, 87 patients with mild cognitive impairment, and 64 patients with clinically diagnosed AD dementia with brain amyloid imaging data available. We demonstrated that four factors among regular health check-up blood tests, cortisol, triglyceride/high-density lipoprotein cholesterol ratio, alanine aminotransferase, and free triiodothyronine, showed either a significant difference by or correlation with cerebral amyloid deposition. Furthermore, we made a prediction model for Pittsburgh compound B-positron emission tomography positivity, using BTFs and the previously discovered blood biomarkers, the QPLEX<sup>TM</sup> Alz plus assay kit biomarker panel, and the area under the curve was significantly increased up to 0.845% with 69.4% sensitivity and 90.6% specificity. These results show that BTFs could be used as co-biomarkers and that a highly advanced prediction model for amyloid plaque deposition could be achieved by the combinational use of diverse biomarkers.
Synthesis of 2′-<i>O</i>-[2-(<i>N</i>-Methylcarbamoyl)ethyl]ribonucleosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides (2011)

To develop oligonucleotides containing new 2'-O-modified ribonucleosides as nucleic acid drugs, we synthesized three types of ribonucleoside derivatives modified at the 2'-hydroxyl group with 2-(methoxycarbonyl)ethyl (MOCE), 2-(N-methylcarbamoyl)ethyl (MCE), and 2-(N,N-dimethylcarbamoyl)ethyl (DMCE) groups, as key intermediates, via the oxa-Michael reaction of the appropriately protected ribonucleoside (U, C, A, and G) derivatives. Among them, the 2'-O-MCE ribonucleosides were found to be the most stable under basic conditions. To study the effects of the 2'-O-modification on the nuclease resistance of oligonucleotides incorporating the 2'-O-modified ribonucleosides and their hybridization affinities for the complementary RNA and DNA strands, 2'-O-MCE-ribonucleoside phosphoramidite derivatives were successfully synthesized and subjected to the synthesis of 2'-O-MCE-oligonucleotides and 2'-O-methyl-oligonucleotides incorporating 2'-O-MCE-ribonucleosides. The 2'-O-MCE-oligonucleotides and chimeric oligomers with 2'-O-MCE and 2'-O-methyl groups thus obtained demonstrated complementary RNA strands and much higher nuclease resistances than the corresponding 2'-O-methylated species. Finally, we incorporated the 2'-O-MCE-ribonucleosides into antisense 2'-O-methyl-oligoribonucleotides to examine their exon-skipping activities in splicing reactions related to pre-mRNA of mouse dystrophin. The exon-skipping assay of these 2'-O-methyl-oligonucleotide incorporating 2'-O-MCE-uridines showed better efficacies than the corresponding 2'-O-methylated oligoribonucleotide phosphorothioate derivatives.
Synthesis and Properties of Hetero-branched Cyclodextrins. (1999)

Hetero-branched cyclodextrins (CDs) were synthesized by transglycosylation or the reverse action of several enzymes such as βββ-galactosidases, α-galactosidases, α-mannosidases, lysozyme and R-Nacetylhexosaminidase. Their structures were analyzed by methylation, FAB-MS, and NMR spectroscopies. β-Galactosidase and a-galactosidase from microorganisms synthesized hetero-branched CDs, of which the galactose residues were linked at side chains of the branched CDs. But these enzymes could not synthesize galactosyl-CDs, directly linked to the CD ring. However, α-galactosidase from coffee bean and α-mannosidase and N-acetylhexosaminidase from jack bean could bind galactosyl, mannosyl and N-acetylglucosaminyl residues directly to the CD rings, respectively, by transglycosylation or reverse action. The effects of the side-chain residues in branched CDs, on solubility, hemolytic activity, and inclusion reactions with 6-O-α-D-glucosyl-CDs, 6-O-α-D-galactosyl-CDs, and 6-O-α-Dmannosyl-CDs, were examined.
Thermally expandable microspheres with excellent expansion characteristics at high temperature (2010)

Abstract Thermally expandable core/shell particles with a poly(acrylonitrile‐ co ‐methacrylonitrile) shell and a hydrocarbon core (blowing agent) have been prepared by suspension polymerization. The objective of this study was to gain a deeper understanding of the parameters determining the expansion properties of these microspheres. It was found that the amount, the boiling point, and the structure of the blowing agent are important parameters for the expansion properties. For example, a higher maximum expansion was reached when using bulkier blowing agents and thus a lower diffusion rate through the polymer shell. Further, the amount and structure of the crosslinker were also found to be essential for the expansion properties. For this particular system, it was found that a dimethacrylate‐functional crosslinker gave significantly better expansion when compared with diacrylate‐ or divinylether‐based crosslinkers. Beside these parameters, it was also observed that the particle‐size distribution influence the expansion properties of the microspheres. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Safety and Dosing of Autologous Neural Progenitors Injected Intrathecally in Multiple Sclerosis Patients: Results of a Pilot Study (P2.221) (2014)

OBJECTIVE: To optimize dosing and to establish short-term and long-term safety of intrathecal injections of autologous mesenchymal stem-cell derived neural progenitors (MSC-NPs) in multiple sclerosis (MS) patients. BACKGROUND: Current MS therapies are only partially effective in slowing down progression and there is need for therapies that can stop or reverse the progression of MS through strategies of neural repair or regeneration. MSC-NPs represent a subpopulation of bone marrow-derived MSCs which have demonstrated therapeutic benefit when injected intrathecally into EAE mice. Here we report on the initial clinical experience with autologous MSC-NPs injected intrathecally in MS patients. This pilot work was conducted to gather information for safety and dosing of this novel cellular therapy to obtain FDA approval for a phase I trial. DESIGN/METHODS: All patients gave informed consent. Retrospective data on the short-term and long-term safety of intrathecal injections of autologous MSC-NPs in 7 patients with progressive forms of MS was analyzed as an IRB-approved chart review. All patients gave informed consent. Subjects were evaluated for degree of disability and adverse events. RESULTS: Seven MS patients received between 2 and 5 treatments of intrathecal autologous MSC-NPs. Dose ranged from 5x10(4) to 1.6x10(7) cells, and treatments were spaced an average of 5 months apart. All patients have been followed to the present time (mean 6.6 years). There were no serious adverse events reported. Of the 22 treatments, mild fever was reported once, mild headache was reported 4 times, and a moderate headache lasting approximately 1 week was reported once, all resolving with an analgesic. Five of the 7 patients treated with MSC-NPs showed clinical improvement as determined by EDSS. CONCLUSIONS: Based on these preliminary results, it was determined that MSC-NP doses of between 2 and 10 million cells would be consistently safe and possibly effective. Preliminary data obtained from this treatment resulted in FDA approval for a phase I study of MSC-NP treatment for 20 MS patients.
Three-dimensional radiative transfer tomography for turbid media (2003)

The photon distribution, as a function of position, angle, and time, is computed using the analytical cumulant solution of the Boltzmann radiative transfer equation (RTE). A linear forward model for light propagation in turbid media for three-dimensional (3-D) optical tomography is formed based on this solution. The model can be used with time resolved, continuous wave (CW), and frequency-domain measurements in parallel geometries. This cumulant forward model (CFM) is more accurate than that based on the diffusion approximation of RTE. An inverse algorithm that incorporates this CFM is developed, based on a fast 3-D hybrid-dual-Fourier tomographic approach using multiple detectors and multiple sources in parallel geometries. The inverse algorithm can produce a 3-D image of a turbid medium with more than 20 000 voxels in 1-2 min using a personal computer. A 3-D image reconstructed from simulated data is presented.
Epitaxial growth of high <i>T</i> <i>c</i> superconducting Nb3Ge on Nb3Ir (1977)

Nb3Ir polycrystalline films with the A15 structure deposited on sapphire were used as substrates for the epitaxial growth of Nb3Ge because of the favorable lattice parameter match. The experimental results clearly show that epitaxial growth indeed occurs and helps to extend the range of homogeneity of the A15 phase up to 26.3 at.% Ge as compared with the thermodynamic equilibrium boundary at 19 at.% Ge. Furthermore, epitaxy results in a considerable rise in the superconducting transition temperature for Ge-rich samples together with a reduction in the transition width.
Modbus Communication Behavior Modeling and SVM Intrusion Detection Method (2016)

The security and typical attack behavior of Modbus/TCP industrial network communication protocol are analyzed. The data feature of traffic flow is extracted through the operation mode of the depth analysis abnormal behavior, and the intrusion detection method based on the support vector machine (SVM) is designed. The method analyzes the data characteristics of abnormal communication behavior, and constructs the feature input structure and detection system based on SVM algorithm by using the direct behavior feature selection and abnormal behavior pattern feature construction. The experimental results show that the method can effectively improve the detection rate of abnormal behavior, and enhance the safety protection function of industrial network.
Dynamic scene occlusion culling (1999)

Large, complex 3D scenes are best rendered in an output-sensitive way, i.e., in time largely independent of the entire scene model's complexity. Occlusion culling is one of the key techniques for output-sensitive rendering. We generalize existing occlusion culling algorithms, intended for static scenes, to handle dynamic scenes having numerous moving objects. The data structure used by an occlusion culling method is updated to reflect the objects' possible positions. To avoid updating the structure for every dynamic object at each frame, a temporal bounding volume (TBV) is created for each occluded dynamic object, using some known constraints on the object's motion. The TBV is inserted into the structure instead of the object. Subsequently, the object is ignored as long as the TBV is occluded and guaranteed to contain the object. The generalized algorithms' rendering time is linearly affected only by the scene's visible parts, not by hidden parts or by occluded dynamic objects. Our techniques also save communications in distributed graphic systems, e.g., multiuser virtual environments, by eliminating update messages for hidden dynamic objects. We demonstrate the adaptation of two occlusion culling algorithms to dynamic scenes: hierarchical Z-buffering and BSP tree projection.
Spatial ray features for real-time ego-lane extraction (2012)

In order to support driver assistance systems in unconstrained environments, we propose to extend local appearance-based road classification with a spatial feature generation and classification. Therefore, a hierarchical approach consisting of multiple low level base classifiers, the novel spatial feature generation, as well as a final road terrain classification, is used. The system perceives a variety of local properties of the environment by means of base classifiers operating on patches extracted from monocular camera images, each represented in a metric confidence map. The core of the proposed approach is the computation of spatial ray features (SPRAY) from these confidence maps. With this, the road-terrain classifier can decide based on local visual properties and their spatial layout in the scene. In order to show the feasibility of the approach, the extraction and evaluation of the metric ego-lane driving corridor on an inner city stream is demonstrated. This is a challenging task because on a local appearance level, ego-lane is not distinguishable from other asphalt parts on the road. However, by incorporating the proposed SPRAY features the distinction is possible without requiring an explicit lane model. Due to the parallel structure of this bottom-up approach, the implemented system operates in real-time with approximately 25 Hz on a GPU.
Morphology and microstructural evolution in the early stages of hydride vapor phase epitaxy of GaN on sapphire (1998)

The early stages of hydride vapor phase epitaxy (HVPE) of GaN on sapphire were studied using atomic force microscopy, field-emission scanning electron microscopy, cross-sectional transmission electron microscopy, and x-ray diffraction rocking curves. At the high growth rate used (∼33 nm/s), the films appear to be fully coalesced for growth periods as short as 1 s. A distinct surface and subsequent bulk transformation were observed, resulting in significantly smoother film surfaces and improved bulk morphology. The growth of thick (i.e., 300 μm) GaN films using HVPE offers a promising technique for the deposition of high-quality substrates for GaN homoepitaxy.
An application of electrothermal feedback for high resolution cryogenic particle detection (1995)

A novel type of superconducting transition edge sensor is proposed. In this sensor, the temperature of a superconducting film is held constant by feeding back to its position on the resistive transition edge. Energy deposited in the film is measured by a reduction in the feedback Joule heating. This mode of operation should lead to substantial improvements in resolution, linearity, dynamic range, and count rate. Fundamental resolution limits are below ΔE=√kT2C, which is sometimes incorrectly referred to as the thermodynamic limit. This performance is better than any existing technology operating at the same temperature, count rate, and absorber heat capacity. Applications include high resolution x-ray spectrometry, dark matter searches, and neutrino detection.
Synthesis of Deoxyribonucleoside Phosphorodithioate Dimers by a Triester Method (1999)

Abstract Modified oligodeoxynucleotides have recently received much attention due to their therapeutic applications. Among the more promising are phosphorodithioates where both nonbridging oxygen atoms in the phosphate diesters are replced by sulfur. Deoxynucleoside phosphorodithioate dimers have been prepared in several ways, using H-phosphonate, phosphordiamidite, phosphoramidite, and thiophosphoramidite methods. Reports have also appeared on the synthesis of oligonucleotides with alternating phosphodiester and dithiophosphodiester linkages, as well as one on ribonucleoside dimers. Of the above methods, the thiophosphoramidite method has been applied successfully for the preparation of mixed base oligonucleotides containing contiguous phosphorodithioate linkages. However, this method gives products which contain varying amounts of phosphorothioate linkages (2 − 10%) due to factors associated with the involvement of trivalent thiophosphorus compounds. In addition, the thiophosphoramidite synthons are difficult to purify on silica gel column, and have a tendency to dismutate in presence of acidic catalysts such as tetrazole. The thiophosphite intermediate which is formed is also unstable to tetrazole. Similarly in the thio- and dithio-H-phosphonate method, the primary coupling products are unstable to catalysts, pivaloyl chloride and iodine. Recently, Dahl et al reported1–2 synthesis of dimers and oligomers upto octamer which also leads to formation of small amounts of phosphorothioate linkages. In additon, about 1.2% per phosphorodithioate linkage of the oligomer is cleaved during
On sound-based interpretation of neonatal EEG (2018)

Significant training is required to visually interpret neonatal EEG signals. This study explores alternative sound-based methods for EEG interpretation which are designed to allow for intuitive and quick differentiation between healthy background activity and abnormal activity such as seizures. A novel method based on frequency and amplitude modulation (FM/AM) is presented. The algorithm is tuned to facilitate the audio domain perception of rhythmic activity which is specific to neonatal seizures. The method is compared with the previously developed phase vocoder algorithm for different time compressing factors. A survey is conducted amongst a cohort of non-EEG experts to quantitatively and qualitatively examine the performance of sound-based methods in comparison with the visual interpretation. It is shown that both sonification methods perform similarly well, with a smaller inter-observer variability in comparison with visual. A post-survey analysis of results is performed by examining the sensitivity of the ear to frequency evolution in audio.
A Robust and Scalable Neuromorphic Communication System by Combining Synaptic Time Multiplexing and MIMO-OFDM (2014)

This paper describes a novel architecture for enabling robust and efficient neuromorphic communication. The architecture combines two concepts: 1) synaptic time multiplexing (STM) that trades space for speed of processing to create an intragroup communication approach that is firing rate independent and offers more flexibility in connectivity than cross-bar architectures and 2) a wired multiple input multiple output (MIMO) communication with orthogonal frequency division multiplexing (OFDM) techniques to enable a robust and efficient intergroup communication for neuromorphic systems. The MIMO-OFDM concept for the proposed architecture was analyzed by simulating large-scale spiking neural network architecture. Analysis shows that the neuromorphic system with MIMO-OFDM exhibits robust and efficient communication while operating in real time with a high bit rate. Through combining STM with MIMO-OFDM techniques, the resulting system offers a flexible and scalable connectivity as well as a power and area efficient solution for the implementation of very large-scale spiking neural architectures in hardware.
Full Single-Phase Behavior at 298K of Li<sub>x</sub>Fe<sub>y</sub>PO<sub>4</sub>-Based Electrodes (2010)

Abstract not Available.
Regeneration of Aluminum Hydride Using Trimethylamine (2011)

Aluminum hydride is an attractive reducing agent and energy storage compound possessing a low decomposition temperature and a high gravimetric and volumetric hydrogen density. However, it is thermodynamically unstable at room temperature and requires extremely high pressures to form the hydride from aluminum and hydrogen gas. Here, we describe an alternate method of synthesizing AlH3 using Ti-catalyzed Al powder, H2, and trimethylamine (TMA) to form an alane adduct. The formation of trimethylamine alane occurs at modest hydrogen pressures (∼100 bar), forming the 2:1 bis complex (2 trimethylamine/AlH3). Along with the hydrogenation product, mono (1:1) and bis (2:1) standards of TMA−AlH3 were prepared and characterized using X-ray diffraction and Raman spectroscopy. X-ray absorption spectroscopy of the reaction products showed that the Ti catalyst remains with the unreacted Al powder after hydrogenation and is not present in the alane adduct. We also demonstrate that TMA can be transaminated with triethylamine to form triethylamine alane, which can easily be separated to recover AlH3.