gebhart/patrepeval huggingface dataset:
Reverse Engineering Based Coil Spring Design Method (2008)

This paper describes a new coil spring design method for automated, optimized and designer-independent design. In conventional coil spring design, a spring profile at free state is usually designed first and it is then compressed in FEA (Finite Element Analysis) to check if the spring characteristics satisfy the required specifications. However, the spring requirements such as rate, load, FLP (Force Line Position), deformed profile, etc. are usually given at the compressed state of the spring. Therefore, if the result does not meet the requirements, a designer must modify the free state profile while predicting how it reflects to the spring characteristics at deformed state. In the new method, the ideal deformed spring profile is designed first and its corresponded unique free profile is then reversely determined by automated FEA iterations in order to satisfy the requirements. By scanning the total number of turns in a certain range for the deformed spring profile designed at the first stage, the optimal spring design can be selected in terms of weight, stress and manufacturability. This paper validates the new method with actual design example. The method and resultant spring shape are currently international patent pending.
High-density erasable three-dimensional optical bit data storage in a photorefractive polymer using two-photon excitation (1999)

Multi-layered (or three-dimensional) optical memories have increasingly become a field of interest of interest in the development of a high density optical data storage devices. Systems that utilise multiple layer recording can achieve recording densities from 100 to 10,000 times higher than conventional optical data storage devices.
Antagonists of Hsp16.3, a Low-Molecular-Weight Mycobacterial Chaperone and Virulence Factor, Derived from Phage-Displayed Peptide Libraries (2005)

The persistence of Mycobacterium tuberculosis is a major cause of concern in tuberculosis (TB) therapy. In the persistent mode the pathogen can resist drug therapy, allowing the possibility of reactivation of the disease. Several protein factors have been identified that contribute to persistence, one of them being the 16-kDa low-molecular-weight mycobacterial heat shock protein Hsp16.3, a homologue of the mammalian eye lens protein alpha-crystallin. It is believed that Hsp16.3 plays a key role in the persistence phase by protecting essential proteins from being irreversibly denatured. Because of the close association of Hsp16.3 with persistence, an attempt has been made to develop inhibitors against it. Random peptide libraries displayed on bacteriophage M13 were screened for Hsp16.3 binding. Two phage clones were identified that bind to the Hsp16.3 protein. The corresponding synthetic peptides, an 11-mer and a 16-mer, were able to bind Hsp16.3 and inhibit its chaperone activity in vitro in a dose-dependent manner. Little or no effect of these peptides was observed on alphaB-crystallin, a homologous protein that is a key component of human eye lens, indicating that there is an element of specificity in the observed inhibition. Two histidine residues appear to be common to the selected peptides. Nuclear magnetic resonance studies performed with the 11-mer peptide indicate that in this case these two histidines may be the crucial binding determinants. The peptide inhibitors of Hsp16.3 thus obtained could serve as the basis for developing potent drugs against persistent TB.
A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels (1988)

Since the discovery of endothelium-dependent vasodilation, vascular endothelium has been recognized as an important functional unit contributing to the regulation of vascular tonus. Recent purification, structure determination and molecular cloning of a novel peptidergic vasoconstrictor, endothelin, from the culture supernatant of porcine aortic endothelial cells has further substantiated this concept. Starting from a large quantity of serum-fee endothelial cell-conditioned medium, endothelin was purified to homogeneity after three steps of high performance liquid chromatography by collecting active fractions and constricting porcine coronary artery strips. A peptide sequence analysis showed that endothelin was a previously unknown 21-residue peptide with two intrachain disulphide bonds. The EC50 of endothelin for contraction of porcine coronary artery was 4.0 x 10(-10) mol/l, indicating that endothelin is one of the most potent vasoconstrictors known. The pharmacological and structural properties of endothelin suggest that the peptide acts by activating voltage-dependent Ca2+ channels in vascular smooth muscle cells. Cloning and sequence analysis of complementary (c)DNA encoding porcine and human endothelin precursors showed that endothelin was produced de novo in endothelial cells from an approximately 200-residue prepropeptide through an unusual proteolytic processing by a putative 'endothelin-converting enzyme'. Northern blot analysis showed that preproendothelin messenger (m)RNA was expressed not only in cultured endothelial cells but also in fresh intimal tissue from porcine aorta, and that mRNA can be induced markedly in response to several vasoactive agents in cultured endothelial cells, suggesting the existence of a novel endothelium-mediated cardiovascular control system.
Retrospective registration-based MRI motion correction with interleaved radial trajectories (2011)

Despite reduction in imaging times through improved hardware and rapid acquisition schemes, motion artifacts can compromise image quality in magnetic resonance imaging (MRI). This is especially true for 3D imaging, where scan durations are prolonged and the assumptions of most state-of-the-art 2D rigid body motion compensation techniques break down. This paper introduces a novel motion correction technique that is capable of restoring image quality in motion corrupted 2D/3D radial acquisitions. First, the available set of projections is subdivided into motion-free subsets of data using a novel center of mass based motion detection approach. For acquisitions with multiple receiver coils, both rotational and translational motion are detected. Next, the motion parameters are estimated on a sub-pixel level by co-registration of the data subsets. This approach does not require any additional navigators or external motion estimation schemes. The capabilities and limitations of the method are described and demonstrated on an application in cranial imaging.
Incoherent Clutter Suppression Using Lag-One Coherence (2020)

The lag-one coherence (LOC), derived from the correlation between the nearest-neighbor channel signals, provides a reliable measure of clutter which, under certain assumptions, can be directly related to the signal-to-noise ratio of individual channel signals. This offers a direct means to decompose the beamsum output power into contributions from speckle and spatially incoherent noise originating from acoustic clutter and thermal noise. In this study, we applied a novel method called lag-one spatial coherence adaptive normalization (LoSCAN) to locally estimate and compensate for the contribution of spatially incoherent clutter from conventional delay-and-sum (DAS) images. Suppression of incoherent clutter by LoSCAN resulted in improved image quality without introducing many of the artifacts common to other adaptive imaging methods. In simulations with known targets and added channel noise, LoSCAN was shown to restore native contrast and increase DAS dynamic range by as much as 10-15 dB. These improvements were accompanied by DAS-like speckle texture along with reduced focal dependence and artifact compared with other adaptive methods. Under in vivo liver and fetal imaging conditions, LoSCAN resulted in increased generalized contrast-to-noise ratio (gCNR) in nearly all matched image pairs ( N = 366 ) with average increases of 0.01, 0.03, and 0.05 in good-, fair-, and poor-quality DAS images, respectively, and overall changes in gCNR from -0.01 to 0.20, contrast-to-noise ratio (CNR) from -0.05 to 0.34, contrast from -9.5 to -0.1 dB, and texture μ/σ from -0.37 to -0.001 relative to DAS.
A biologically inspired gripping device (2005)

Purpose The purpose of this paper is to inform the readers of the design process and practical implications of a new gripping device created by the authors. Design/methodology/approach We have developed a novel gripping device based on the biomechanics of the feeding apparatus of the marine mollusk, Aplysia californica . The gripping device uses modified McKibben artificial muscles arranged in rings and placed in parallel. The rings contract sequentially to produce peristalsis, which moves a grasping mechanism back and forth through the rings. Findings The central grasper is capable of conforming to soft and irregular material. Practical implications This device could have novel applications both for removal of tissue in medical applications and for removing material from clogged plumbing lines. Originality/value This paper demonstrates the utility of using biological inspiration for developing novel robotic devices and suggests new ways of handling slippery, irregular, and fragile material.
Diamond electronics (2016)

We would like to introduce diamond junction field effect transistors for next generation power electronics and magnetic sensing devices by applying advanced diamond device technologies.
The sun protection factor (SPF) inadequately defines broad spectrum photoprotection: demonstration using skin reconstructed in vitro exposed to UVA, UVBor UV-solar simulated radiation. (2003)

Wavelength specific biological damage has been previously identified in human skin reconstructed in vitro. Sunburn cell and pyrimidine dimers were found after UVB exposure, and alterations of dermal fibroblasts after UVA exposure. These damages permitted us to discriminate UVB and UVA single absorbers. The present study shows that these biological effects can be obtained simultaneously by a combined UVB + UVA exposure using ultraviolet solar simulated light (UV-SSR), which represents a relevant UV source. In addition, the protection afforded by two broad spectrum sunscreen complex formulations was assessed after topical application. These two formulations displayed the same sun protection factor but different UVA protection factors determined by the persistent pigment darkening (PPD) method. Dose response experiments of UVA or UV-SSR showed that the preparation with the highest PF-UVA provided a better protection with regard to dermal damage compared to the other formulation. Using an original UVB source to obtain the UVB portion of SSR spectrum, the preparations provided the same protection. This study strikingly illustrates the fact that the photoprotection afforded by two sunscreen formulations having similar SPF values is not equal with regard to dermal damage related to photoaging.
Prospective, randomized comparison in humans of a unipolar defibrillation system with that using an additional superior vena cava electrode. (1994)

The unipolar single-lead transvenous defibrillation system provides defibrillation at energy levels comparable to that reported with present epicardial lead systems. Coupling of this lead system to a third SVC electrode increases system complexity but offers little defibrillation advantage despite a large decrease in pulsing resistance and a modest increase in delivered current.
Synthesis of Novel Lipophilic N-Substituted Norcantharimide Derivatives and Evaluation of Their Anticancer Activities (2014)

This research attempted to study the effect of lipophilicity on the anticancer activity of N-substituted norcantharimide derivatives. Twenty-three compounds were synthesized and their cytotoxicities against five human cancer cell lines studied. The lipophilicity of each derivative was altered by its substituent, an alkyl, alkyloxy, terpenyl or terpenyloxy group at the N-position of norcantharimide. Further, among all synthesized derivatives studied, the compounds N-farnesyloxy-7-oxabicyclo[2.2.1]heptane-2,3-dicarboximide (9), and N-farnesyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboximide (18), have shown the highest cytotoxicity, anti-proliferative and apoptotic effect against human liver carcinoma HepG2 cell lines, yet displayed no significant cytotoxic effect on normal murine embryonic liver BNL CL.2 cells. Their overall performance led us to believe that these two compounds might be potential candidates for anticancer drugs development.
Common-mode backchannel signaling system for differential high-speed links (2004)

Common-mode signaling is effectively used to create a backchannel communication path over the existing pair of wires for a self-contained adaptive differential high-speed link transceiver cell. A transceiver chip was designed in 0.13 /spl mu/m CMOS to demonstrate the feasibility of simultaneous differential and common-mode signaling. The design uses a three-level return-to-null signaling scheme with simultaneous voltage and timing reference extraction, to minimize the hardware costs and achieve robust operation for sending update information from receiver to the transmitter. The measured results indicate that this backchannel achieves reliable communication without noticeable impact on the forward link for bandwidths up to 50MHz and swings of 20-100mV.
Navigating the cache hierarchy with a single lookup (2014)

Modern processors optimize for cache energy and performance by employing multiple levels of caching that address bandwidth, low-latency and high-capacity. A request typically traverses the cache hierarchy, level by level, until the data is found, thereby wasting time and energy in each level. In this paper, we present the Direct-to-Data (D2D) cache that locates data across the entire cache hierarchy with a single lookup.
Work Load Scheduling For Multi Core Systems With Under-Provisioned Power Delivery (2017)

An energy efficient power delivery method for multi-core systems with under-provisioned on-chip voltage regulators has been proposed in literature. The power delivery network is reconfigurable at run-time to meet the varying current demands of the cores exceeding the maximum output current rating of the voltage regulators. In this paper, a real-timeworkload scheduling heuristic is developed that assigns the tasks to the cores such that the total load current consumption of the cores is always less than the total current capability of the under-provisioned on-chip voltage regulators. In addition, the energy-efficient scheduling of the tasks on to the cores ensures that the reconfiguration of the power delivery network is minimized. The heuristic includes DVFS management based on the unique constraints of the under provisioned voltage regulators. The work load scheduler is evaluated on homogeneous and heterogeneous multi-core platforms based on the Exynos 5410 big.LITTLE architecture. The proposed workload scheduler along with the run time voltage regulator clustering algorithm proposed in the literature provides a robust cross-layer power management technique for under-provisioned on-chip power delivery.
Molecular and Immunological Characterization of a Wheat Serine Proteinase Inhibitor as a Novel Allergen in Baker's Asthma (2008)

IgE-mediated sensitization to wheat flour belongs to the most frequent causes of occupational asthma. A cDNA library from wheat seeds was constructed and screened with serum IgE from baker's asthma patients. One IgE-reactive phage clone contained a full-length cDNA coding for an allergen with a molecular mass of 9.9 kDa and an isoelectric point of 6. According to sequence analysis it represents a member of the potato inhibitor I family, a group of serine proteinase inhibitors, and thus is the first allergen belonging to the group 6 pathogenesis-related proteins. The recombinant wheat seed proteinase inhibitor was expressed in Escherichia coli and purified to homogeneity. According to circular dichroism analysis, it represented a soluble and folded protein with high thermal stability containing mainly beta-sheets, random coils, and an alpha-helical element. The recombinant allergen showed allergenic activity in basophil histamine release assays and reacted specifically with IgE from 3 of 22 baker's asthma patients, but not with IgE from grass pollen allergic patients or patients suffering from food allergy to wheat. Allergen-specific Abs were raised to localize the allergen by immunogold electron microscopy in the starchy endosperm and the aleuron layer. The allergen is mainly expressed in mature wheat seeds and, despite an approximately 50% sequence identity, showed no relevant cross-reactivity with allergens from other plant-derived food sources such as maize, rice, beans, or potatoes. Recombinant wheat serine proteinase inhibitor, when used in combination with other specific allergens, may be useful for the diagnosis and therapy of IgE-mediated baker's asthma.
A real-time orbit SATellites Uncertainty propagation and visualization system using graphics computing unit and multi-threading processing (2015)

This paper presents a real-time propagating and visualizing the uncertainty of multiple orbit satellites within the framework of graphics computing unit and multi-threading processing. The paper presents a system to predict the future position and velocity of orbiting objects based on a Monte Carlo method with multi-threading (Central Processing Unit (CPU)) and multi-stream (Graphics Processing Unit (GPU)) processing for the application of multiple satellite orbits estimation, collision probability calculation and visualization. The introduced SATellite Uncertinty Processing with GpU and Multi-threading (SAT-UPGUM) approach is general purpose in the sense that it can extended to other types of Space Situation Awareness (SSA) applications such as Stochastic Collocation, Pursui-Evasion, and Patterns of Life. The GPU based computing leads to a real-time outcome of orbit satellites uncertainty propagation and visualization compared to the situations when the whole work flow is applied in CPU only. The obtained propagation results for the multiple satellite orbits indicate that our GPU and multi-threading based approach provides dramatically improved frame rate under realistic conditions.
KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum (2003)

Benign familial neonatal convulsions (BFNC) is a rare autosomal dominant generalized epilepsy of the newborn infant. Seizures occur repeatedly in the first days of life and remit by approximately 4 months of age. Previously our laboratory cloned two novel potassium channel genes, KCNQ2 and KCNQ3, and showed that they are mutated in patients with BFNC. In this report, we characterize the breakpoints of a previously reported interstitial deletion in the KCNQ2 gene and show that only KCNQ2 is deleted. We identify 11 novel mutations in KCNQ2 and one novel mutation in the KCNQ3 potassium channel genes. In one family, the phenotype extends beyond neonatal seizures and includes rolandic seizures, and a subset of families has onset of seizures in infancy. In the Xenopus oocyte expression system, we characterize five KCNQ2 and one KCNQ3 disease-causing mutations. These mutations cause a variable loss of function, and selective effects on the biophysical properties of KCNQ2/KCNQ3 heteromultimeric channels. We report here the first dominant negative mutation in KCNQ2 that has a phenotype of neonatal seizures without permanent clinical CNS impairment.
Current Technologies to Endotoxin Detection and Removal for Biopharmaceutical Purification (2019)

Endotoxins are considered as the major contributors to the pyrogenic response observed with contaminated pharmaceutical products. Recombinant biopharmaceutical products are manufactured using living organisms, including gram-negative bacteria. Upon the death of a gram-negative bacteria, endotoxins (also known as lipopolysaccharides; LPS) in the outer cell membrane are released into the lysate where it can interact with and form bonds with biomolecules, including target therapeutic compounds. Endotoxin contamination of biologic products may also occur through water, raw materials such as excipients, media, additives, sera, equipment, containers closure systems, and expression systems used in manufacturing. The manufacturing process is therefore in critical need to reduce and remove endotoxins by monitoring raw materials and in-process intermediates at critical steps, in addition to final drug product release testing. In this review, a discussion regarding the progression of endotoxin detection techniques, from crude to refined are presented. We provide a brief overview of the upstream processed used to manufacture therapeutic products and then discuss various downstream purification techniques widely used to purify the products off endotoxins. Finally, we investigate the effectiveness of endotoxin purification processes, both from a perspective of precision as well as cost-effectiveness.
Beam shaper with optimized dose utility for helical cone-beam CT (2011)

Purpose: To develop a new design of an x-ray beam shaper for helical computed tomography (CT) that increases the dose utilization.Methods: For typical reconstruction algorithms in helical CT, different data are utilized with different weights during back-projection. In particular, data of the outer detector rows, i.e., data acquired at larger cone-angles, are used with smaller weights than data from the central detector rows. Given this spatial variation of the back-projection weights, a beam shaper is designed that creates a spatial variation of the noise variance across the detector such that the used back-projection weights are the statistically optimal weights. The effect of the beam shaper on the reconstructed images are studied using simulated data and analytical as well as iterative reconstruction algorithms.Results: For a particular analytical reconstruction algorithm, we obtain an average reduction of the noise by 12% within the object. In combination with iterative reconstruction, the beam shaper creates an insensitivity to patient motion without introducing any heuristic data weighting.Conclusions: The demonstrated noise reduction by 12% is equivalent to a possible dose saving of 25%. This dose saving can be achieved by a relatively minor hardware change in the CT system and it does not require any changes to the reconstruction algorithm.
Forward Bias Inhibits Single-Event Upsets (1990)

Bipolar integrated circuits more resistant to ionizing radiation. Tests show resistance of bipolar integrated logic or memory circuit by single-event upsets increased by imparting forward bias to diode constituted by buried layer of substrate and collector.
Coherent Measurements with Fiber-Laser Frequency Combs (2009)

The coherent and broad spectral output of fiber-laser frequency combs can be exploited for a variety of high-resolution measurements outside of conventional frequency metrology. We will discuss recent measurements in spectroscopy, ranging, and telecommunication components.
Required Friction Utilization for Friction Estimation on Wet Asphalt, an Experimental Study (2017)

Real-time information about the friction coefficient between the tyre and the road can be used to improve active safety systems and is an enabler for autonomous vehicles. Large tyre force excitation is normally required to obtain an accurate friction estimate. This paper quan-tifies this requirement for four different tyre models on wet salted asphalt at water freezing tem-peratures. Cost functions and different tyre models are evaluated and the results are compared to a previous study performed for snow conditions. The suitability of commonly used tyre models for friction estimation on snow and wet asphalt has thus been investigated.