gebhart/patrepeval huggingface dataset:
Alterations in the Local Myocardial Motion Pattern in Patients Suffering From Pressure Overload Due to Aortic Stenosis (1999)

Torsional behavior as observed in pressure- and volume-overloaded hearts is consistent with current theoretical findings. A delayed diastolic untwisting in the pressure-overloaded hearts of the patients may contribute to a tendency toward diastolic dysfunction.
Biodistribution, Tumor Detection, and Radiation Dosimetry of <sup>18</sup>F-DCFBC, a Low-Molecular-Weight Inhibitor of Prostate-Specific Membrane Antigen, in Patients with Metastatic Prostate Cancer (2012)

Although further studies are needed for validation, our findings demonstrate the potential of (18)F-DCFBC as a new positron-emitting imaging agent for the detection of metastatic PCa. This study also provides dose estimates for (18)F-DCFBC that are comparable to those of other PET radiopharmaceuticals such as (18)F-FDG.
Operational transformation in real-time group editors (1998)

Rd-time group editors dow a group of users to view and edit, the same document at the same time horn geograpbicdy di.~ersed sites connected by communication networks. Consistency maintenance is one of the most si@cant &alwiges in the design and implementation of thwe types of systems. R=earch on rd-time group editors in the past decade has invented au inuolative tetique for consistency maintenance, ded operational transformation This paper presents an integrative review of the evolution of operational tra=formation techniques, with the go~of identifying the major is-m~s, dgotiths, achievements, and remaining Mlenges. In addition, this paper contribut= a new optimized generic operational transformation control algorithm.
Standards-based approaches to 3D and multiview video coding (2009)

The extension of video applications to enable 3D perception, which typically is considered to include a stereo viewing experience, is emerging as a mass market phenomenon, as is evident from the recent prevalence of 3D major cinema title releases. For high quality 3D video to become a commonplace user experience beyond limited cinema distribution, adoption of an interoperable coded 3D digital video format will be needed. Stereo-view video can also be studied as a special case of the more general technologies of multiview and "free-viewpoint" video systems. The history of standardization work on this topic is actually richer than people may typically realize. The ISO/IEC Moving Picture Experts Group (MPEG), in particular, has been developing interoperability standards to specify various such coding schemes since the advent of digital video as we know it. More recently, the ITU-T Visual Coding Experts Group (VCEG) has been involved as well in the Joint Video Team (JVT) work on development of 3D features for H.264/14496-10 Advanced Video Coding, including Multiview Video Coding (MVC) extensions. This paper surveys the prior, ongoing, and anticipated future standardization efforts on this subject to provide an overview and historical perspective on feasible approaches to 3D and multiview video coding.
The biological effects of XTC-MIF: quantitative comparison with <i>Xenopus</i> bFGF (1990)

Mesoderm in Xenopus and other amphibian embryos is induced by signals from the vegetal hemisphere acting on equatorial or animal hemisphere cells. These signals are diffusible and two classes of candidate signal molecule have been identified: the fibroblast growth factor (FGF) and transforming growth factor beta (TGF-beta) types. In this paper, we compare the effects of cloned Xenopus basic FGF (XbFGF) and electophoretically homogeneous XTC-MIF (a TGF-beta-like factor obtained from a Xenopus cell line) on animal pole explants. We find that they have a similar minimum active concentration (0.1-0.2 ng ml-1) but that, nonetheless, XTC-MIF is at least 40 times more active in inducing muscle. In general, we find that the two factors cause inductions of significantly different characters in terms of tissue type, morphology, gene expression and timing. At low concentrations (0.1-1.0 ng ml-1) both factors induce the differentiation of 'mesenchyme' and 'mesothelium' as well as blood-like cells. These latter cells do not, however, react with an antibody to Xenopus globin. This raised the possibility that the identification of red blood cells in other studies on mesoderm induction might have been mistaken, but combinations of animal pole regions with ventral vegetal pole regions confirmed that genuine erythrocytes are formed. The identity of the blood-like cells formed in response to the inducing factors remains unknown. At higher concentrations XTC-MIF induces neural tissue, notochord, pronephros and substantial and often segmented muscle. By contrast, XbFGF only induces significant amounts of muscle above 24 ng ml-1 and even then this is much less than that induced by XTC-MIF. For both factors an exposure of less than 30 min is effective. Competence of animal pole cells to respond to XbFGF is completely lost by the beginning of gastrulation (stage 10) while competence to XTC-MIF is detectable until somewhat later (stage 11). Since animal pole tissue is known to be able to respond to the natural inducer at least until stage 10, and perhaps until stage 10.5, this suggests that bFGF cannot be the sole inducer of mesoderm in vivo. Taken together, these results are consistent with XTC-MIF being a dorsoanterior inducer and XbFGF a ventroposterior inducer, suggesting that body pattern is established by the interaction of two types of inducing signal. This model is discussed in view of the qualitative and quantitative differences between the factors.
Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs (2019)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most important causes of peptic ulcer disease in high-income countries. Proton pump inhibitors are the current standard treatment; however, safety and long-term adverse effects of using these drugs are attracting more and more concerns in recent years. Using a porcine model of NSAID-related gastric ulcer, we herein show that adipose-derived mesenchymal stem cells (ADMSCs) delivered by endoscopic submucosal injection promoted ulcer healing with less inflammatory infiltration and enhanced reepithelization and neovascularization at day 7 and day 21 when compared with the controls (saline injection). However, only few engrafted ADMSCs showed myofibroblast and epithelial cell phenotype in vivo, suggesting the ulcer healing process might be much less dependent on the stem cell transdifferentiation. Further experiment with submucosal injection of MSC-derived secretome revealed a therapeutic efficacy comparable to that of stem cell transplantation. Profiling analysis showed up-regulation of genes associated with inflammation, granulation formation, and extracellular matrix remodeling at day 7 after injection of MSC-derived secretome. In addition, the extracellular signal-regulated kinase/mitogen-activated protein kinase and the phosphoinositide-3-kinase/protein kinase B pathways were activated after injection of ADMSCs or MSC-derived secretome. Both signaling pathways were involved in mediating the major events critical to gastric ulcer healing, including cell survival, migration, and angiogenesis. Our data suggest that endoscopic submucosal injection of ADMSCs serves as a promising approach to promote healing of NSAID-related peptic ulcer, and the paracrine effectors released from stem cells play a crucial role in this process.
A new method for OOV detection using hybrid word/fragment system (2009)

In this paper, we propose a new method for detecting regions with out-of-vocabulary (OOV) words in the output of a large vocabulary continuous speech recognition (LVCSR) system. The proposed method uses a hybrid system combining words and data-driven variable length sub word units. With the use of a single feature, the posterior probability of sub word units, this method outperforms existing methods published in the literature. We also presents a recipe to discriminatively train a hybrid language model to improve OOV detection rate. Results are presented on the RT04 broadcast news task.
A processor-time-minimal systolic array for cubical mesh algorithms (1992)

Using a directed acyclic graph (DAG) model of algorithms, the paper focuses on time-minimal multiprocessor schedules that use as few processors as possible. Such a processor-time-minimal scheduling of an algorithm's DAG first is illustrated using a triangular shaped 2-D directed mesh (representing, for example, an algorithm for solving a triangular system of linear equations). Then, algorithms represented by an n*n*n directed mesh are investigated. This cubical directed mesh is fundamental; it represents the standard algorithm for computing matrix product as well as many other algorithms. Completion of the cubical mesh required 3n-2 steps. It is shown that the number of processing elements needed to achieve this time bound is at least (3n/sup 2/4/). A systolic array for the cubical directed mesh is then presented. It completes the mesh using the minimum number of steps and exactly (3n/sup 2/4/) processing elements it is processor-time-minimal. The systolic array's topology is that of a hexagonally shaped, cylindrically connected, 2-D directed mesh.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Analysis of long queries in a large scale search log (2009)

We propose to use the search log to study long queries, in order to understand the types of information needs that are behind them, and to design techniques to improve search effectiveness when they are used. Long queries arise in many different applications, such as CQA (community-based question answering) and literature search, and they have been studied to some extent using TREC data. They are also, however, quite common in web search, as can be seen by looking at the distribution of query lengths in a large scale search log.
A Hybrid Natural Gas Electric Fleet Vehicle (1996)

<div class="htmlview paragraph">A project that retrofits a GM/Vehma electric G-Van with valve-regulated lead acid batteries and a natural gas power unit is described. The goal of the project is to develop a control strategy and system to minimize both the emissions and the costs of operation of the hybrid vehicle.</div> <div class="htmlview paragraph">The conceptual development of a control system for a light-duty fleet vehicle is presented. Control requirements of a series hybrid propulsion system are discussed based upon the analysis of factors affecting its operation. Specifically, the effects of the duty cycle are investigated in detail. A concept of a control system is introduced and modeled using MATLAB/Simulink software. The model input is validated by monitored trials of the vehicle. Various control strategy options are evaluated for typical operating conditions.</div> <div class="htmlview paragraph">The projected vehicle emission are estimated by simulation. The quantities of ground level emissions are presented for various urban routes in Vancouver.</div>
Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype (2010)

ATP-binding cassette, subfamily G, member 2 (ABCG2) is expressed in both normal and cancer cells and plays a crucial role in side population (SP) formation and efflux of xenobiotics and drugs. Nrf2, a redox-sensing transcription factor, on constitutive activation in non-small-cell lung cancer cells upregulates a wide spectrum of genes involved in redox balance, glutathione metabolism, and drug detoxification, which contribute to chemoresistance and tumorigenicity. This study examined the mechanism underlying Nrf2-dependent expression of ABCG2 and its role in the multidrug resistance phenotype. In silico analysis of the 5'-promoter flanking region of ABCG2 identified an antioxidant response element (ARE) at -431 to -420 bp. A detailed promoter analysis using luciferase reporter assays showed that ARE at -431 to -420 bp is critical for the Nrf2-mediated expression in lung cancer cells. Electrophoretic mobility shift assays and chromatin immunoprecipitation assays revealed that Nrf2 interacts with the ABCG2 ARE element at -431 to -420 bp in vitro and in vivo. Disruption of Nrf2 expression in lung and prostate cancer cells, by short hairpin RNA, attenuated the expression of ABCG2 transcript and protein, and dramatically reduced the SP fraction in Nrf2-depleted cancer cells. Moreover, depleted levels of ABCG2 in these Nrf2 knockdown cells sensitized them to mitoxantrone and topotecan, two chemotherapy drugs detoxified mainly by ABCG2. As expected, overexpression of Nrf2 cDNA in lung epithelial cells led to an increase in ABCG2 expression and a 2-fold higher SP fraction. Thus, Nrf2-mediated regulation of ABCG2 expression maintains the SP fraction and confers chemoresistance.
Asymmetric Enamine Catalysis (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric Enamine CatalysisSantanu Mukherjee, Jung Woon Yang, Sebastian Hoffmann, and Benjamin ListView Author Information Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany Cite this: Chem. Rev. 2007, 107, 12, 5471–5569Publication Date (Web):December 12, 2007Publication History Received28 August 2007Published online12 December 2007Published inissue 1 December 2007https://pubs.acs.org/doi/10.1021/cr0684016https://doi.org/10.1021/cr0684016research-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views56266Altmetric-Citations2550LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Aldol reactions,Catalysts,Ketones,Stereoselectivity Get e-Alerts
Efficient Object Tracking System Using the Fusion of a CCD Camera and an Infrared Camera (2011)

To make a robust object tracking and identifying system for an intelligent robot and/or home system, heterogeneous sensor fusion between visible ray system and infrared ray system is proposed. The proposed system separates the object by combining the ROI (Region of Interest) estimated from two different images based on a heterogeneous sensor that consolidates the ordinary CCD camera and the IR (Infrared) camera. Human's body and face are detected in both images by using different algorithms, such as histogram, optical-flow, skin-color model and Haar model. Also the pose of human body is estimated from the result of body detection in IR image by using PCA algorithm along with AdaBoost algorithm. Then, the results from each detection algorithm are fused to extract the best detection result. To verify the heterogeneous sensor fusion system, few experiments were done in various environments. From the experimental results, the system seems to have good tracking and identification performance regardless of the environmental changes. The application area of the proposed system is not limited to robot or home system but the surveillance system and military system.
Pulsed-Current Plating (1994)

Abstract Pulsed-current plating can be defined simply as metal deposition by pulsed electrolysis, which involves using interrupted direct current to electroplate parts. This article discusses the advantages and limitations of pulsed-current plating and provides information on the process principles and control, solution composition, operating conditions, and necessary equipment modifications.
Novel Method for Assessment of His Bundle Pacing Morphology Using Near Field and Far Field Device Electrograms (2019)

We propose a novel and simple criteria for accurate differentiation between S-HBP, NS-HBP, and right ventricular septal capture morphologies by careful analysis of device EGMs alone. This study paves the way for future studies to assess autocapture algorithms for devices with HBP.
Human high molecular weight kininogen binds to human umbilical vein endothelial cells via its heavy and light chains (1993)

High molecular weight kininogen (HK) is a multifunctional plasma glycoprotein that occupies a critical position in pathways that link inflammation and coagulation. Excision of the vasoactive peptide bradykinin by plasma kallikrein results in kinin-free HK that consists of a 65-Kd N-terminal heavy chain (HK-HC) linked to the C-terminal 45- Kd light chain (HK-LC) by a disulfide bridge. HK-HC is an inhibitor of SH-proteases and HK-LC contains the binding sites for coagulation cofactors prekallikrein and factor XI. HK has previously been shown to bind specifically to human umbilical vein endothelial cells (HUVEC) in a zinc(2+)-dependent manner by a single class of high-affinity binding sites. We have further characterized that interaction in order to determine the cell-binding regions of HK. Competition binding experiments have indicated that either HK-LC or HK-HC was able to inhibit the binding of labeled HK with a 50% inhibitory concentration (IC50) of 77 nmol/L and 89 nmol/L, respectively. Cleaved two-chain HK (HKa) had an IC50 of 73 nmol/L, whereas uncleaved HK had an IC50 of 335 nmol/L. Direct binding experiments have indicated that HUVEC bind both purified [125I]HK-HC and [125I]HK-LC in a zinc(2+)-dependent manner and that HK-LC did not displace bound HK-HC. The light chain of low molecular weight kininogen or prekallikrein-binding region of HK did not inhibit the binding of HK to HUVEC. Our results, therefore, indicate that (1) HK is capable of binding to endothelial cells via both heavy and light chain moieties, (2) HKa has a higher affinity to HUVEC, and (3) purified heavy and light chains are capable of directly binding to HUVEC. The data are consistent with the presence of a single high-affinity site for HK on endothelial cells within which are subsites that bind to heavy and light chains.
Molecular tuning of fast gating in pentameric ligand-gated ion channels (2005)

Neurotransmitters such as acetylcholine (ACh) and glycine mediate fast synaptic neurotransmission by activating pentameric ligand-gated ion channels (LGICs). These receptors are allosteric transmembrane proteins that rapidly convert chemical messages into electrical signals. Neurotransmitters activate LGICs by interacting with an extracellular agonist-binding domain (ECD), triggering a tertiary/quaternary conformational change in the protein that results in the fast opening of an ion pore domain (IPD). However, the molecular mechanism that determines the fast opening of LGICs remains elusive. Here, we show by combining whole-cell and single-channel recordings of recombinant chimeras between the ECD of alpha7 nicotinic receptor (nAChR) and the IPD of the glycine receptor (GlyR) that only two GlyR amino acid residues of loop 7 (Cys-loop) from the ECD and at most five alpha7 nAChR amino acid residues of the M2-M3 loop (2-3L) from the IPD control the fast activation rates of the alpha7/Gly chimera and WT GlyR. Mutual interactions of these residues at a critical pivot point between the agonist-binding site and the ion channel fine-tune the intrinsic opening and closing rates of the receptor through stabilization of the transition state of activation. These data provide a structural basis for the fast opening of pentameric LGICs.
Microwave frequency reference based on VCSEL-driven dark-line resonances in Cs vapor (2002)

Dark-line resonances in Cs vapor are studied for potential use in a compact, low-power microwave frequency reference. The resonance is excited using light from a VCSEL and detected using the change in DC absorption, resulting in an extremely simple physics package with very high tolerance to misalignment and potentially low acceleration sensitivity. We anticipate engineering the package developed into a device with a volume less than 1 cm/spl times/1 cm/spl times/2 cm and a power dissipation of much less than 100 mW, depending on the thermal environment.
A 0.1-pJ/b/dB 1.62-to-10.8-Gb/s Video Interface Receiver With Jointly Adaptive CTLE and DFE Using Biased Data-Level Reference (2020)

In this article, a 1.62-to-10.8-Gb/s video interface receiver with jointly adaptive equalization is presented. Sign-sign least-mean-squares (SSLMS) algorithm is applied to adaptation for not only a decision feedback equalizer (DFE) but also a continuous-time linear equalizer (CTLE) to unify the adaptation methods. This approach facilitates concurrent adaptation that results in short adaptation time and also reduces the extra hardware and power consumption. An average value of fourth- and fifth-post-cursors is used as an indicator for CTLE adaptation, and the validity is substantiated by numerical analysis and simulation. Furthermore, the concept of a biased data-level reference (dLev) is proposed and analyzed to alleviate insufficient adaptation of the SSLMS algorithm in the presence of pre-cursor inter-symbol interference (ISI). The proposed dLev is acquired by simply adjusting up and down ratios of the dLev update equation. The prototype test chip is implemented in 65-nm CMOS technology and occupies an active area of 0.174 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The proposed adaptive equalizers compensate for the channel loss of up to 34 dB at 10.8 Gb/s. Total power consumption of the receiver is 37.2 mW at 10.8 Gb/s, and the figure of merit (energy efficiency per channel loss at Nyquist frequency) of 0.1 pJ/b/dB is achieved.
Hepatocyte growth factor promotes colonic epithelial regeneration via Akt signaling (2007)

Hepatocyte growth factor (HGF) can promote the regeneration of injured organs, including HGF gene therapy by electroporation (EP) for liver injury. In this study, we investigated the effect of HGF on dextran sulfate sodium-induced colitis and tried to clarify the regenerative mechanisms of colonic epithelial cells and the signaling pathway involved. Colitis was induced by dextran sulfate sodium in mice, together with HGF gene transfer by EP. On day 10, the colitis was evaluated histologically and by Western blot analysis. The colonic epithelial cell line MCE301 was exposed to HGF protein, and its proliferation and activated signaling pathway were analyzed. In vivo, the histological score improved and the number of Ki-67-positive epithelial cells increased in the HGF-treated mice compared with the controls. Western blot analysis showed enhanced expression of phospho-Akt in the HGF-treated mice compared with the controls. In vitro, HGF stimulated the proliferation of MCE301 cells. There was enhanced phospho-Akt expression for more than 48 h after HGF stimulation, although phospho-ERK1/2 was enhanced for only 10 min. LY-294002 or Akt small interfering RNA suppressed cell proliferation induced by HGF. Thus HGF induces the proliferation of colonic epithelial cells via the phosphatidylinositol 3-kinase/Akt signaling pathway. HGF gene therapy can attenuate acute colitis via epithelial cell proliferation through the PI3K/Akt pathway. These data suggested that HGF gene therapy by EP may be effective for the regeneration and repair of injured epithelial cells in inflammatory bowel disease.