gebhart/patrepeval huggingface dataset:
Automatic conflation of digital maps (1993)

A consolidation method for combining geometrical and attribute data from two digital map sources, A and B, into one, ultimate map is described. This method is called "conflation" and its requires identification of the matching elements on both maps: vertices, arcs, and areas. Conflation generally consists of two parts (automatic and manual). The method is based on the usage of the chains of arcs in order to determine the matching intersections between them. The chains are formed a priori by using both attribute and geometric properties of the arcs. The intersections are treated as relations between chains and are stored in a simple external relational database.
Design and simulation of a 2-DOF parallel linear precision platform utilizing piezoelectric impact drive mechanism (2019)

With rapid developments of micro/nano science and technology, precision platforms are widely required in the research and industry fields. This paper presents a 2-DOF parallel linear precision platform utilizing piezoelectric impact drive mechanism. With symmetrical flexible structure and specific piezoelectric driving manner, effective and decoupled actuation of the stator is achieved. FEA simulations are conducted to investigate the characteristics of the stator. With established dynamic model of the platform, motion responses of stator and slider in the two directions are simulated and analyzed. With simultaneous actuation of the 2-DOF motions, a motion interaction phenomenon is raised and discussed.
L'evolució de la biblioteca de la UOC : perspectives de futur (2010)

La Biblioteca de la Universitat Oberta de Catalunya ofereix els seus serveis de manera virtual des de la seva creació, l'any 1995. Per això, l'aposta per les noves tecnologies del moment ha estat una constant durant aquests anys. A continuació, a través d'una breu menció a l'evolució històrica, es comenten els serveis i recursos oferts de forma pionera a nivell de biblioteques universitàries. S'analitzen els aspectes més destacables pel que fa als serveis, la gestió de la col·lecció, la formació, i la relació amb la Universitat, en el moment actual. Per concloure, es fa una anàlisi dels principals reptes de futur que la Biblioteca espera afrontar en els propers anys, tenint com a referent principal els usuaris i les innovacions tecnològiques que permetin donar resposta a les noves necessitats que vagin sorgint. Tot això, per continuar sent capdavantera en l'àmbit de les biblioteques virtuals.
Type II protein C deficiency: identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity (2000)

Two mutations in exons 3 and 9 of the protein C gene were identified by amplification and sequencing from symptomatic probands referred for venous thromboembolism and thrombophilia screening. The phenotype associated with the mutations is a type II protein C deficiency with normal amidolytic activity. In one family, the mutation in exon 3 (G3545-->A), which predicts an R9 to H substitution in the Gla domain, was identified. A mutation in exon 9 (G10899-->A), which predicts an R352 to W substitution in the catalytic site, was identified in the second family and has been reported previously in association with type II deficiency with low amidolytic activity. Western blotting of the purified proteins from the probands' plasma did not show any abnormal migratory pattern. Molecular modelling suggested a possible impairment in the recently described Na+ binding pocket for the R352-->W mutant. No conclusions could be drawn relative to the R9-->H mutant.
Molecular and experimental virulence of<i>Listeria monocytogenes</i>strains isolated from cases with invasive listeriosis and febrile gastroenteritis (2004)

We analyzed 27 Listeria monocytogenes strains of serotypes 1/2b and 4b, from invasive and gastroenteric listeriosis, for molecular and experimental virulence. Molecular virulence was tested by PCR for the presence of 8 major virulence-associated genes and genetic polymorphisms through restriction enzyme analysis; genomic DNA typing using pulsed-field gel electrophoresis was also performed. Experimental virulence was evaluated through intra-peritoneal and intra-gastric mouse virulence assays. Our results showed no significant differences in the virulence-related molecular properties of the strains analyzed. All strains were equally pathogenic following intra-peritoneal inoculation of mice. In mice inoculated intra-gastric with 4 representative strains of the 2 types of listeriosis, there were no significant differences in the bacterial count when comparing invasive and gastroenteric strains, suggesting that the strains were comparable in terms of mean oral infectivity.
Induction thermography as a tool for reliable detection of surface defects in forged components (2022)

Dynamic thermography with inductive excitation is analysed as an alternative to magnetic particle inspection or to eddy current testing. Given by the relation of the electromagnetic skin depth, the thermal penetration depth and the crack dimensions to be detected, different regimes for defect detection are identified. The effect of the crack parameters length, depth and inclination angle are discussed. In ferritic steel, at induction frequencies of 100-200 kHz, perpendicular open cracks with a length of 7.5 mm were detectable when their depth was minimum 0.15 mm. For inclined cracks, the sensitivity is even higher. Experiments were performed on cold and warm forged steel components. The signal-to noise ratio obtained from defects was usually high, the critical limitation on technical surfaces is the background due to surface roughness and due to surface contamination. A series investigation on forged components showed a good probability of detection and a low false alarm rate compared to magnetic particle testing. The short testing times of a few 100 ms per object view will allow short cycle times for mass products.
'Nulling' filters and the separation of transparent motions (2002)

Using low-order global motion hypotheses and the assumption that there are no more than two motions at a single point, it is possible to successfully decompose motion stimuli that contain additively combined transparent layers. It is assumed that the space of flow fields is sufficiently smooth that a relatively coarse sampling of the flow parameter(s) will produce a set of vector fields that can be combined to reasonably approximate the actual motions in the scene. The definition of support from an exclusively spatial notion is extended to include the spatio-temporal energy domain. The key insight is that when processing transparent motion displays, the support of a motion hypothesis should exist over both a region of space and velocity, so that it can be isolated both spatially and in terms of local velocity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses (2007)

Natural killer (NK) cells directly lyse tumor or viral-infected cells but also an important role for NK cell cytotoxicity in regulating the extent of immune responses is emerging. Here, we show that autologous human macrophages activated NK cell proliferation and cytokine secretion, increased expression of activating receptors, and primed NK cell cytotoxicity against susceptible target cells. Ligation of NK cell 2B4, and not NKp30 (known to be important for DC-mediated NK cell activation), is critical for this macrophage-mediated NK cell activation. Reciprocally, however, NK cells regulated macrophage activity by directly killing macrophages stimulated by high doses of LPS. Cytolysis was triggered by NKG2D recognition of stress-inducible class I major histocompatibility complex (MHC)-like ligands on macrophages: high doses of LPS induced transcription and surface expression of ULBP1, ULBP2, and ULBP3 and surface expression of constitutively transcribed MICA. Thus, these data suggest a new function for NK cell cytotoxicity in eliminating overstimulated macrophages. Additionally, these interactions define, for the first time, 2 distinct activating NK cell synapses: lytic and nonlytic. Triggering NK cell proliferation and cytokine secretion, but not cytolysis, specifically associated with synaptic accumulation of macrophage F-actin and NK cell 2B4, while macrophages were killed when NK cell F-actin and macrophage ICAM-1 accumulated around a central cluster of NK cell NKG2D/DAP10.
Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome (2010)

To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of 192 children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in Childhood studies was evaluated with regard to karyotypic complexity. Structurally complex constitutes a new definition of complex karyotype characterized by more than or equal to 3 chromosomal aberrations, including at least one structural aberration. Five-year overall survival in patients with more than or equal to 3 clonal aberrations, which were not structurally complex, did not differ from that observed in patients with normal karyotype. Cox regression analysis revealed the presence of a monosomal and structurally complex karyotype to be strongly associated with poor prognosis (hazard ratio = 4.6, P < .01). Notably, a structurally complex karyotype without a monosomy was associated with a very short 2-year overall survival probability of only 14% (hazard ratio = 14.5; P < .01). The presence of a structurally complex karyotype was the strongest independent prognostic marker predicting poor outcome in children with advanced myelodysplastic syndrome.
CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice (2011)

In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR) chloride channels causes defective secretion by submucosal glands (SMGs), leading to persistent bacterial infection that damages airways and necessitates tissue repair. SMGs are also important niches for slow-cycling progenitor cells (SCPCs) in the proximal airways, which may be involved in disease-related airway repair. Here, we report that calcitonin gene-related peptide (CGRP) activates CFTR-dependent SMG secretions and that this signaling pathway is hyperactivated in CF human, pig, ferret, and mouse SMGs. Since CGRP-expressing neuroendocrine cells reside in bronchiolar SCPC niches, we hypothesized that the glandular SCPC niche may be dysfunctional in CF. Consistent with this hypothesis, CFTR-deficient mice failed to maintain glandular SCPCs following airway injury. In wild-type mice, CGRP levels increased following airway injury and functioned as an injury-induced mitogen that stimulated SMG progenitor cell proliferation in vivo and altered the proliferative potential of airway progenitors in vitro. Components of the receptor for CGRP (RAMP1 and CLR) were expressed in a very small subset of SCPCs, suggesting that CGRP indirectly stimulates SCPC proliferation in a non-cell-autonomous manner. These findings demonstrate that CGRP-dependent pathways for CFTR activation are abnormally upregulated in CF SMGs and that this sustained mitogenic signal alters properties of the SMG progenitor cell niche in CF airways. This discovery may have important implications for injury/repair mechanisms in the CF airway.
From Point Cloud to Building Information Model: Capturing and Processing Survey Data Towards Automation for High Quality 3D Models to Aid a BIM Process (2016)

Building Information Modelling has, more than any previous initiative, established itself as the process by which operational change can occur, driven by a desire to eradicate the inefficiencies in time and value and requiring a change of approach to the whole lifecycle of construction from design through construction to operation and eventual demolition. BIM should provide a common digital platform which allows different stakeholders to supply and retrieve information thereby reducing waste through enhanced decision making. Through the provision of measurement and representative digital geometry for construction and management purposes, surveying is very much a part of BIM. Given that all professions that are involved with construction have to consider the way in which they handle data to fit with the BIM process, it stands to reason that Geomatic or Land Surveyors play a key part. This is further encouraged by the fact that 3D laser scanning has been adopted as the primary measurement technique for geometry capture for BIM. Also it is supported by a laser scanning work stream from the UK Government backed BIM Task Group. Against this backdrop, the research in this thesis investigates the 3D modelling aspects of BIM, from initial geometry capture in the real world, to the generation and storage of the virtual world model, while keeping the workflow and outputs compatible with the BIM process. The focus will be made on a key part of the workflow for capturing as-built conditions: the geometry creation from point clouds. This area is considered a bottleneck in the BIM process for existing assets not helped by their often poor or non-existent documentation. Automated modelling is seen as desirable commercially with the goal of reducing time, and therefore cost, and making laser scanning a more viable proposition for a range of tasks in the lifecycle.
Acyl-acyl carrier protein specificity of UDP-GlcNAc acyltransferases from gram-negative bacteria: relationship to lipid A structure (1991)

Lipid A, the component of lipopolysaccharide that provides the membrane anchor of the core and O-antigen sugars, is known to contain characteristic R-3-hydroxy fatty acids bound to the 2,2' (N-linked) and 3,3' (O-linked) positions of the glucosamine disaccharide in different gram-negative bacteria. The studies reported here show that it is the acyl-acyl carrier protein specificities of the enzymes UDP-GlcNAc-O-acyltransferase and UDP-3-O-[(R)-3-hydroxyacyl]-GlcN-N-acyltransferase that determine the nature of these fatty acids.
The <i>in vivo</i> role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy (2001)

Stress-induced mitogen-activated protein kinase (MAP) p38 is activated in various forms of heart failure, yet its effects on the intact heart remain to be established. Targeted activation of p38 MAP kinase in ventricular myocytes was achieved in vivo by using a gene-switch transgenic strategy with activated mutants of upstream kinases MKK3bE and MKK6bE. Transgene expression resulted in significant induction of p38 kinase activity and premature death at 7-9 weeks. Both groups of transgenic hearts exhibited marked interstitial fibrosis and expression of fetal marker genes characteristic of cardiac failure, but no significant hypertrophy at the organ level. Echocardiographic and pressure-volume analyses revealed a similar extent of systolic contractile depression and restrictive diastolic abnormalities related to markedly increased passive chamber stiffness. However, MKK3bE-expressing hearts had increased end-systolic chamber volumes and a thinned ventricular wall, associated with heterogeneous myocyte atrophy, whereas MKK6bE hearts had reduced end-diastolic ventricular cavity size, a modest increase in myocyte size, and no significant myocyte atrophy. These data provide in vivo evidence for a negative inotropic and restrictive diastolic effect from p38 MAP kinase activation in ventricular myocytes and reveal specific roles of p38 pathway in the development of ventricular end-systolic remodeling.
Shape-selective cleavage of tRNAPhe by transition metal complexes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTShape-selective cleavage of tRNAPhe by transition metal complexesChristine S. Chow and Jacqueline K. BartonCite this: J. Am. Chem. Soc. 1990, 112, 7, 2839–2841Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ja00163a076https://doi.org/10.1021/ja00163a076research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of nitridation on the growth of GaN on ZrB2(0001)∕Si(111) by molecular-beam epitaxy (2006)

The effect of nitridation on the epitaxial growth of GaN on lattice-matched ZrB2(0001) films prepared ex situ and in situ was studied using an ultrahigh-vacuum molecular-beam epitaxy (MBE)-scanning probe microscopy system. The growth of GaN was carried out by rf-plasma-assisted MBE, and epitaxy of wurtzite GaN was observed on both ex situ and in situ prepared ZrB2 samples. The polarity was found to be consistently N-polar regardless of the samples, based on the observation of a series of N-polar Ga-rich reconstructions: (3×3), (6×6), and c(6×12). The nitridation of ZrB2 film was conducted by exposing it to active nitrogen and well-ordered hexagonal-BN (h-BN) formation was observed when the annealing temperature was above 900°C. The partially formed BN layer affected neither the epitaxy nor the polarity of GaN, but when the surface was fully covered with well-ordered h-BN, GaN growth did not occur.
Estimates of Mouse Oviductal Fluid Tonicity Based on Osmotic Responses of Embryos1 (1999)

Zygotes and early cleavage-stage embryos are very sensitive to increased osmolality in vitro, although the tonicity of their in vivo environment, oviductal fluid, is unknown. A preference for low osmolality in vitro might imply similar conditions in vivo or be specific to culture. Previous electron probe x-ray microanalysis measurements of total ion content predicted oviductal fluid osmolalities of 310-360 mOs/kg, higher than osmolalities tolerated by mouse zygotes in vitro. However, such indirect estimates may not reflect the tonicity experienced by embryos. We have now used embryos themselves as osmosensors to determine the tonicity of mouse oviductal fluid. In one method, we measured the mean volume of zygotes in undiluted oviductal fluid and compared this to the mean volumes measured for zygotes in media spanning a range of osmolalities. The osmolality corresponding to the measured mean volume in oviductal fluid was taken to be isotonic. In another, independent method, the sizes of zygotes and two-cell embryos were measured as a function of time beginning immediately after removal from oviducts. The osmolality in which the embryos neither swelled nor shrank was taken to be isotonic. Both methods yielded approximately the same range for the tonicity of oviductal fluid: around 290-300 mOs/kg.
The capacity of highway with mixture of bicycle traffic (2021)

The aim of this paper is to discuss the effect of bicycle flow on vehicle flow when the two different types of traffic move on one road without dividing strips. The study was done by means of photographic measurement because the conventional methods were inadaptable to the subject. After careful investigation and analysis, the author derives a series of relations to explain the variations of vehicle speed with a change of bicycle flow, puts forward a set of coefficients to discount the capacity per motor lane on the road with mixture of bicycle traffic, and recommends a criterion to build-up the facilities such as separator, divisor or divisional island etc. in the hope that the study will be beneficial to road planners and traffic engineers.
Repulsion of Superinfecting Virions: A Mechanism for Rapid Virus Spread (2010)

Viruses are thought to spread across susceptible cells through an iterative process of infection, replication, and release, so that the rate of spread is limited by replication kinetics. Here, we show that vaccinia virus spreads across one cell every 75 minutes, fourfold faster than its replication cycle would permit. To explain this phenomenon, we found that newly infected cells express two surface proteins that mark cells as infected and, via exploitation of cellular machinery, induce the repulsion of superinfecting virions away toward uninfected cells. Mechanistically, early expression of proteins A33 and A36 was critical for virion repulsion and rapid spread, and cells expressing these proteins repelled exogenous virions rapidly. Additional spreading mechanisms may exist for other viruses that also spread faster than predicted by replication kinetics.
Sprachtherapeutische Apps am Beispiel neolexon: Herausforderungen beim Zugang in die Versorgung und Chancen für Therapeuten und Patienten (2021)

Sprachtherapeutische Apps können die Therapie von Patienten1 unterstützen und das häusliche Eigentraining erleichtern. So kann beispielweise die Individualisierung des Sprachmaterials verbessert und die Therapieintensität um ein Vielfaches erhöht werden. In der Entwicklungsgruppe Klinische Neuropsychologie wurden im Projekt neolexon 3 digitale Anwendungen für die Sprachtherapie entwickelt. Dabei mussten besondere Herausforderungen beim Zugang in die Versorgung gemeistert werden.
Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein (2011)

The absorption and transport mechanisms of berberine, palmatine, jateorhizine, and coptisine were studied using a Caco-2 cells uptake and transport model, with the addition of cyclosporin A and verapamil as P-glycoprotein (P-gp) inhibitors and MK-571 as a multidrug resistance-associated protein 2 (MRP(2)) inhibitor. In the uptake experiment, berberine, palmatine, jateorhizine, and coptisine were all taken into Caco-2 cells, and their uptakes were increased in the presence of cyclosporin A or verapamil. In the transport experiment, P(app) (AP-BL) was between 0.1 and 1.0 × 10(6) cm/sec for berberine, palmatine, jateorhizine, and coptisine and was lower than P(app) (BL-AB). ER values were all >2. Cyclosporin A and verapamil both increased P(app) (AP-BL) but decreased P(app) (BL-AB) for berberine, palmatine, jateorhizine, and coptisine; ER values were decreased by >50%. MK-571 had no influence on the transmembrane transport of berberine, palmatine, jateorhizine, and coptisine. At a concentration of 1-100 μM, berberine, palmatine, jateorhizine, and coptisine had no significant effects on the bidirection transport of Rho123. Berberine, palmatine, jateorhizine, and coptisine were all P-gp substrates; and at the range of 1-100 μM, berberine, palmatine, jateorhizine, and coptisine had no inhibitory effects on P-gp.