gebhart/patrepeval huggingface dataset:
DC arc extinction using external magnetic field in switching device (2003)

In this paper, the electromagnetic force acting on the arc column of 3 different type extinction units is compared using the FEM (finite element method) and the arc velocity is calculated by the drag force of the fluid mechanics. The experiment for breaking was performed in each model at 100 V in order to measure the arcing time. And its result was compared with computing values, the confirmed validity of theory. As a result, this paper proposes that the divided U-shaped grid is able to shorten arcing time and improve of the electric performance. And it suggests a methodology for comparing and analyzing the results obtained by simulation and experiment.
Artificial MicroRNAs Targeting C9orf72 Can Reduce Accumulation of Intra-nuclear Transcripts in ALS and FTD Patients (2019)

The most common pathogenic mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an intronic GGGGCC (G<sub>4</sub>C<sub>2</sub>) repeat in the chromosome 9 open reading frame 72 (C9orf72) gene. Cellular toxicity due to RNA foci and dipeptide repeat (DPR) proteins produced by the sense and antisense repeat-containing transcripts is thought to underlie the pathogenesis of both diseases. RNA sequencing (RNA-seq) data of C9orf72-ALS patients and controls were analyzed to better understand the sequence conservation of C9orf72 in patients. MicroRNAs were developed in conserved regions to silence C9orf72 (miC), and the feasibility of different silencing approaches was demonstrated in reporter overexpression systems. In addition, we demonstrated the feasibility of a bidirectional targeting approach by expressing two concatenated miC hairpins. The efficacy of miC was confirmed by the reduction of endogenously expressed C9orf72 mRNA, in both nucleus and cytoplasm, and an ∼50% reduction of nuclear RNA foci in (G<sub>4</sub>C<sub>2</sub>)<sub>44</sub>-expressing cells. Ultimately, two miC candidates were incorporated in adeno-associated virus vector serotype 5 (AAV5), and silencing of C9orf72 was demonstrated in HEK293T cells and induced pluripotent stem cell (iPSC)-derived neurons. These data support the feasibility of microRNA (miRNA)-based and AAV-delivered gene therapy that could alleviate the gain of toxicity seen in ALS and FTD patients.
Strain-specific and immunodominant surface epitopes of the P2 porin protein of nontypeable Haemophilus influenzae (1991)

The P2 porin protein is the major outer membrane protein of nontypeable Haemophilus influenzae. Five monoclonal antibodies to P2 of four strains of nontypeable H. influenzae were developed by immunizing mice with whole bacterial cells. All five antibodies recognized epitopes on P2 in immunoblot assays of whole organism lysates, purified outer membrane, and purified P2. Competitive enzyme-linked immunosorbent assays and immunoblot assays of cyanogen bromide-digested P2 showed that two antibodies to the P2 protein of strain 1479 recognized different epitopes on the molecule. Immunofluorescence and immunoelectron microscopy demonstrated that each of the five antibodies recognized epitopes that were abundantly expressed on the bacterial surface. Analysis of 120 H. influenzae strains indicated that three of the five antibodies were reactive exclusively with the homologous strain. The remaining two antibodies were reactive with less than 3% of the strains. These studies indicate that the P2 protein expresses a highly strain-specific and immunodominant epitope on the bacterial surface. The expression of strain-specific and immunodominant epitopes on the bacterial surface may represent a mechanism by which the bacterium induces antibodies that will protect against recurrent infection by the homologous strain but will not protect against infection by heterologous strains.
Effect of probiotic CenBiot on the control of diarrhoea and feed efficiency in pigs (1998)

Journal Article Effect of probiotic CenBiot on the control of diarrhoea and feed efficiency in pigs Get access Zani, Zani Faculdade de Veterinária, Universidade Federal de Pelotas, Campus Universitario, Pelotas, RS, BrazilCentro de Biotecnologia (CenBiot) Search for other works by this author on: Oxford Academic Google Scholar Weykamp da Cruz, Weykamp da Cruz Centro de Biotecnologia (CenBiot) Search for other works by this author on: Oxford Academic Google Scholar Freitas dos Santos, Freitas dos Santos Centro de Biotecnologia (CenBiot) Search for other works by this author on: Oxford Academic Google Scholar Gil‐Turnes Gil‐Turnes Faculdade de Veterinária, Universidade Federal de Pelotas, Campus Universitario, Pelotas, RS, BrazilCentro de Biotecnologia (CenBiot) Search for other works by this author on: Oxford Academic Google Scholar Journal of Applied Microbiology, Volume 84, Issue 1, 1 January 1998, Pages 68–71, https://doi.org/10.1046/j.1365-2672.1997.00309.x Published: 01 January 1998 Article history Received: 22 November 1996 Revision received: 04 April 1997 Accepted: 22 April 1997 Published: 01 January 1998
High speed decoding of context-based adaptive binary arithmetic codes using most probable symbol prediction (2006)

Context-based adaptive binary arithmetic coding (CABAC) is the major entropy-coding algorithm employed in H.264/AVC. Although the performance gain of H.264/AVC is mostly resulted from CABAC, it is difficult to achieve a fast decoder because the decoding algorithm is basically sequential. In this paper, a prediction scheme is proposed to enhance overall decoding performance by decoding two binary symbols at a time. A CABAC decoder based on the proposed prediction scheme improves the decoding performance by 24% compared to conventional decoders.
LogCut - Efficient Graph Cut Optimization for Markov Random Fields (2007)

Markov Random Fields (MRFs) are ubiquitous in low- level computer vision. In this paper, we propose a new approach to the optimization of multi-labeled MRFs. Similarly to a-expansion it is based on iterative application of binary graph cut. However, the number of binary graph cuts required to compute a labelling grows only logarithmically with the size of label space, instead of linearly. We demonstrate that for applications such as optical flow, image restoration, and high resolution stereo, this gives an order of magnitude speed-up, for comparable energies. Iterations are performed by "fusion" of solutions, done with QPBO which is related to graph cut but can deal with non-submodularity. At convergence, the method achieves optima on a par with the best competitors, and sometimes even exceeds them.
[Molecular targeted therapy and genomic evolution of breast cancer]. (2015)

Owing to development of next generation sequencer (NGS), deep biological insights of breast cancer have been provided. Information of genomic mutations and rearrangements in patients' tumors is required to understand the mechanism in resistance of molecular targeted medicine. To date, NGS analyses illustrated not only base substitution patterns and lists of driver mutations and key rearrangements, but also a manner of tumor evolution. Breast cancer genome is dynamically changing and evolving during cancer development course and treatment procedures. Liquid biopsy is a non-invasive method to detect the genomic evolution of breast cancer, which is now under development for future application to clinical practice of cancer treatment. In this article, latest knowledge regarding breast cancer genome, especially in terms of 'evolution', is summarized.
Theoretical variance analysis of single- and dual-energy computed tomography methods for calculating proton stopping power ratios of biological tissues (2010)

We discovered an empirical relationship between the logarithm of mean excitation energy (ln Im) and the effective atomic number (EAN) of human tissues, which allows for computing patient-specific proton stopping power ratios (SPRs) using dual-energy CT (DECT) imaging. The accuracy of the DECT method was evaluated for 'standard' human tissues as well as their variance. The DECT method was compared to the existing standard clinical practice-a procedure introduced by Schneider et al at the Paul Scherrer Institute (the stoichiometric calibration method). In this simulation study, SPRs were derived from calculated CT numbers of known material compositions, rather than from measurement. For standard human tissues, both methods achieved good accuracy with the root-mean-square (RMS) error well below 1%. For human tissues with small perturbations from standard human tissue compositions, the DECT method was shown to be less sensitive than the stoichiometric calibration method. The RMS error remained below 1% for most cases using the DECT method, which implies that the DECT method might be more suitable for measuring patient-specific tissue compositions to improve the accuracy of treatment planning for charged particle therapy. In this study, the effects of CT imaging artifacts due to the beam hardening effect, scatter, noise, patient movement, etc were not analyzed. The true potential of the DECT method achieved in theoretical conditions may not be fully achievable in clinical settings. Further research and development may be needed to take advantage of the DECT method to characterize individual human tissues.
Prostaglandin analogs possessing antinidatory effects. 1. Modification of the .omega. chain (1980)

Novel prostaglandin analogues modified in the omega chain were prepared by the reaction of the vinyl aldehydes 1a--e with a variety of organometallic reagents as a key step of the syntheses. Compared with the natural prostaglandin F2 alpha in antinidatory effect, the analogues 4, 7, and 10 were 40 times more potent and the analogue 11 was 50--100 times more potent in the rat.
Characterization of the Structure of Saudi Crude Asphaltenes by X-ray Diffraction (1997)

Structural characterization studies have been carried out on four commercial Saudi Arabian crude oils. The aromaticity and crystallite parameters of the asphaltenes were studied by X-ray diffraction methods and compared to the average structural parameters calculated from nuclear magnetic resonance spectra.
Validation (2018)

Before JSF transfers data into the model, the raw data has to be converted and validated. A short overview of bean validation was introduced in Chapter 15. As stated there, JSF offers its own validation specification besides bean validation. Although bean validation is the newer technique, it’s not a replacement for the older JSF validation—sometimes it’s very handy to use this “old” validation.
MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications (2013)

Inclusions comprising the microtubule (MT)-stabilizing protein, tau, are found within neurons in the brains of patients with Alzheimer's disease and related neurodegenerative disorders that are broadly referred to as tauopathies. The sequestration of tau into inclusions is believed to cause a loss of tau function, such that MT structure and function are compromised, leading to neuronal damage. Recent data reveal that the brain-penetrant MT-stabilizing agent, epothilone D (EpoD), improves cognitive function and decreases both neuron loss and tau pathology in transgenic mouse models of tauopathy. There is thus a need to identify additional MT-stabilizing compounds with blood-brain barrier (BBB) permeability and slow brain clearance, as observed with EpoD. We report here that the MT-stabilizing natural product, dictyostatin, crosses the BBB in mice and has extended brain retention. Moreover, a single administration of dictyostatin to mice causes prolonged stabilization of MTs in the brain. In contrast, the structurally related MT-stabilizer, discodermolide, shows significantly less brain exposure. Thus, dictyostatin merits further investigation as a potential tauopathy therapeutic.
Modeling class cohesion as mixtures of latent topics (2009)

The paper proposes a new measure for the cohesion of classes in object-oriented software systems. It is based on the analysis of latent topics embedded in comments and identifiers in source code. The measure, named as maximal weighted entropy, utilizes the latent Dirichlet allocation technique and information entropy measures to quantitatively evaluate the cohesion of classes in software. This paper presents the principles and the technology that stand behind the proposed measure. Two case studies on a large open source software system are presented. They compare the new measure with an extensive set of existing metrics and use them to construct models that predict software faults. The case studies indicate that the novel measure captures different aspects of class cohesion compared to the existing cohesion measures and improves fault prediction for most metrics, which are combined with maximal weighted entropy.
Sulfiredoxin Redox-Sensitive Interaction with S100A4 and Non-Muscle Myosin IIA Regulates Cancer Cell Motility (2012)

Sulfiredoxin (Srx) is a redox active protein that participates in the reduction of oxidized cysteine residues. Here we identify a novel function of Srx through its specific binding to S-glutathionylated S100A4 affecting its interaction with non-muscle myosin (NMIIA), thereby modulating the effect of S100A4 on NMIIA function and impacting cell adhesion and migration. Srx forms a complex with S100A4 (and has stronger affinity for S-glutathionylated S100A4), regulates its activity, and mediates redox regulation of the interaction of S100A4 with NMIIA. The consequence of this regulation is microfilament remodeling and altered cellular motility and adhesion. Srx-overexpressing cells had reduced levels of adhesion, decreased levels of Tyr(397)-phosphorylated focal adhesion kinase, and increased cell motility in wound healing assays. These results describe a novel redox-sensitive role for Srx in mediating complex protein interactions with plausible consequences for cancer cell motility.
Reform and Innovation in Guzheng Education Teaching Model (2023)

The reform and innovation of the Guzheng (Chinese zither) education and teaching model are of great significance in cultivating students' music literacy, creativity, and comprehensive abilities. The traditional Guzheng education model emphasizes technical training but often overlooks students' personalized development and holistic cultivation. The reformed and innovative teaching model can better stimulate students' creativity and expressive abilities by encouraging their participation in activities such as composition and performance. Personalized learning and teaching are important directions for Guzheng education reform, tailoring instructional content and progress to students' interests and characteristics while providing personalized feedback and guidance. Integration of modern technological methods is also a crucial aspect of Guzheng education and teaching model reform, utilizing online resources for learning and communication, as well as employing multimedia technologies such as audio and video for teaching and demonstration purposes, thereby offering diverse, convenient learning approaches and teaching resources. Through reform and innovation, Guzheng education can better meet students' needs and promote their comprehensive development in music literacy, creativity, and overall abilities.
From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1) (2019)

Protein-protein interactions (PPIs) have emerged as significant targets for therapeutic development, owing to their critical nature in diverse biological processes. An ideal PPI-based target is the protein myeloid cell leukemia 1 (MCL1), a critical prosurvival factor in cancers such as multiple myeloma where MCL1 levels directly correlate to disease progression. Current strategies for halting the antiapoptotic properties of MCL1 revolve around inhibiting its sequestration of proapoptotic factors. Existing inhibitors disrupt endogenous regulatory proteins; however, this strategy actually leads to an increase of MCL1 protein levels. Here, we show the development of hetero-bifunctional small molecules capable of selectively targeting MCL1 using a proteolysis targeting chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon ubiquitination pathway, making these PROTACs a first step toward a new class of antiapoptotic B-cell lymphoma 2 family protein degraders.
Botulinum Neurotoxins and Cancer—A Review of the Literature (2020)

Botulinum neurotoxins (BoNT) possess an analgesic effect through several mechanisms including an inhibition of acetylcholine release from the neuromuscular junction as well as an inhibition of specific pain transmitters and mediators. Animal studies have shown that a peripheral injection of BoNTs impairs the release of major pain transmitters such as substance P, calcitonin gene related peptide (CGRP) and glutamate from peripheral nerve endings as well as peripheral and central neurons (dorsal root ganglia and spinal cord). These effects lead to pain relief via the reduction of peripheral and central sensitization both of which reflect important mechanisms of pain chronicity. This review provides updated information about the effect of botulinum toxin injection on local pain caused by cancer, painful muscle spasms from a remote cancer, and pain at the site of cancer surgery and radiation. The data from the literature suggests that the local injection of BoNTs improves muscle spasms caused by cancerous mass lesions and alleviates the post-operative neuropathic pain at the site of surgery and radiation. It also helps repair the parotid damage (fistula, sialocele) caused by facial surgery and radiation and improves post-parotidectomy gustatory hyperhidrosis. The limited literature that suggests adding botulinum toxins to cell culture slows/halts the growth of certain cancer cells is also reviewed and discussed.
Compact meander monopole antenna for tri‐band WLAN application (2007)

Abstract A novel printed meander monopole antenna for tri‐band wireless local area network (WLAN) applications is presented. The antenna is composed of a meander strip and a straight strip with a gap between the ends of them, both printed on an inexpensive FR4 substrate, and is fed by a 50 Ω microstrip feeder with the notched ground plane. The operation bandwidth of the proposed antenna covers 2.4, 5.2, and 5.8 GHz WLAN bands with light weight and compact radiator size of only 12 × 7 mm 2 . © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 986–988, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22314
0.5W class two-stage 4K pulse tube cryorefrigerator. (2000)

Cryomech, Inc. has developed and commercialized a two-stage 4 K Pulse Tube Cryorefrigerator, the Model PT4-05. Because of the absence of moving parts and cold seals, the PT4-05 has extra lower vibrations, higher reliability and longer meantime between maintenance than the existing 4.2 K options. The PT4-05 is powered by the new Cryomech CP950 Compressor Package; consuming 4.7kW of input power, to provide 0.57 W at 4.2 K on the second stage with 18 W at 65 K on the first stage. The COP at 4.2 K is 1.2×10 -4 . The PT4-05 reaches minimum temperature, 2.65 K, in 65 minutes. There has been no degradation in the performance of the PT4-05 presently under life test during more than 3,000 hours of operation and 90 cool-down and warm-up procedures. The meantime between maintenance is forecasted to be >20,000 hours.
Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer (2015)

Circulating microRNAs (miRNAs) have been reported as a biomarker for human malignancies, including colorectal cancer (CRC). The purpose of this study was to identify a novel biomarker for CRC through examination of serum miRNAs from the patients with CRC. Microarray analysis of miRNA expression was performed using paired pre- and post-operative serum from 10 CRC patients. miR-103 and miR-720 decreased significantly in the post-operative serum when compared to pre-operative serum. With an extended scale validation by qRT-PCR (quantitative real-time polymerase chain reaction) in 30 CRC patients, we confirmed that serum miR-103 and miR-720 decreased significantly after surgery (P=0.0004, and P=0.0274, respectively). Next, we examined serum miR-103 and miR-720 levels in 32 non-cancer patients and 84 CRC patients, and we found that expression of these two miRNAs was significantly higher in CRC patients than non-cancer patients. Furthermore, clinical and pathological survey indicated that high expression of miR-103 was significantly associated with histological differentiation grade, and lymphatic invasion and high expression of miR-720 was significantly associated with male gender and lymph node metastasis. Our data suggest that circulating miR-103 and miR-720 show potential as novel serum biomarkers for CRC.
Rapid estimation of 4DCT motion‐artifact severity based on 1D breathing‐surrogate periodicity (2014)

The breathing periodicity index and motion-artifact severity index are introduced to assess the relationship between 1DRW and 4DCT. A correlation between 1DRW periodicity and 4DCT artifact severity has been established. The 1DRW periodicity provides a rapid means to estimate 4DCT image quality. The rapid 1DRW analysis and the correlative relationship can be applied prospectively to identify irregular breathers as candidates for breath coaching prior to 4DCT scan and retrospectively to select high-quality 4DCT images for clinical motion-management research.
Long-haul WDM transmission system by use of high alumina codoped EDFAs and gain-equalizers (2002)

To expand the signal wavelength bandwidth in a long-haul, large-capacity WDM transmission system, we developed a high alumina codoped EDFA with broadband, high output power, and low noise figure using a 1480-nm pump laser. We applied gain-equalizers (GEQs) using Mach-Zehnder type optical filters with long free-spectral ranges to accurately compensate for the gain-wavelength characteristics of the EDFA. We investigated the signal wavelength bandwidth expanded by using the above EDFAs and GEQs. The achieved signal wavelength bandwidth after 10000-km transmission was 18 nm. We successfully transmitted 170 Gbit/s (32 channel/spl times/5.332 Gbit/s) WDM signals over 9879 km and 700 Gbit/s (66 channel/spl times/10.66 Gbit/s) WDM signals over 2212 km.
Liver-Specific β-Catenin Knockout Mice Have Bile Canalicular Abnormalities, Bile Secretory Defect, and Intrahepatic Cholestasis (2010)

Liver-specific loss of β-catenin leads to defective bile canalicular morphology, bile secretory defect, and intrahepatic cholestasis. Thus, our results establish a critical role for β-catenin in biliary physiology.