gebhart/patrepeval huggingface dataset:
<i>BRAF</i> and <i>NRAS</i> mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors (2008)

Oncogenic BRAF and NRAS mutations are frequent in malignant melanoma. BRAF that is activated by the common V600E and other mutations, as well as by upstream NRAS mutations, has been shown to require the molecular chaperone heat shock protein 90 (HSP90) for stabilization and is depleted by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG)]. Here, we explore the possible relationship between tumor BRAF and NRAS mutations and clinical response to 17-AAG in six patients with metastatic malignant melanoma who received pharmacologically active doses of 17-AAG as part of a phase I clinical trial. One patient with disease stabilization for 49 months had a (G13D)NRAS mutation and (WT)BRAF. A second patient who had stable disease for 15 months had a (V600E)BRAF mutation and (WT)NRAS. These preliminary results suggest that BRAF and NRAS mutation status should be determined in prospective phase II studies of HSP90 inhibitors in melanoma.
La teorización de la percepción en la praxis del diseño arquitectónico. (2019)

La percepción es empleada en diversos contextos para entender la realidad, un producto de la mente que permite la contemplación del mundo mediante los sentidos aristotélicos que permiten organizar la información sin considerarlos como simples captadores de la existencia del ser. El presente artículo plantea la necesidad de incorporar la teoría de la percepción en el desarrollo y práctica del diseño arquitectónico, a través de los estímulos del cerebro debido a la complejidad del sistema perceptivo, la teorización ofrece nuevas oportunidades para experimentar desde el inicio del proceso creativo. Comprender que la teoría no es únicamente para trabajos científicos, sino que se trata de un sistema complejo, donde todos los componentes son interdependientes. Se explica de manera breve como incorporar la teoría de la percepción en la realización del diseño arquitectónico, basado en una experiencia fenomenológica–hermenéutica.
Endoderm induction for hepatic and pancreatic differentiation of ES cells. (2008)

Hepatic and pancreatic differentiation from ES cells is of great interest for the impact that this knowledge could have on the treatment of hepatic and diabetic patients. The liver and pancreas initially develop by budding from the embryonic endoderm. Thus, the development of the endoderm represents an important step and has an integral common role in initiating the early stages of pancreatic and liver development. We know that the development of hepatocytes and insulin-producing pancreatic beta-cells from ES cells represents the culmination of a complex developmental program. However, there has been recent progress in directing ES cells to endoderm and early-stage hepatic and pancreatic progenitor cells. We here discuss the role of the microenvironment, transcriptional factors and cytokines, which have been recognized as important molecules during the major steps of the development of the liver and pancreas. We also present the most recent advances and efforts taken to produce definitive endoderm-committed ES cells for the further differentiation of hepatocyte-like and insulinproducing cells. Recent progress in the search for new sources of hepatocytes and beta-cells has opened up several possibilities for the future of new perspectives for future of new prophylactic and therapeutic possibilities for liver diseases and diabetes.
A process for solid fat from castor oil by simultaneous hydrogénation and dehydration (1991)

A single step process has been developed on a pilot plant scale (15 kg/batch) for simultaneous hydrogenation and dehydration of castor oil using nickel catalyst and attapulgite to yield solid fats having a hydroxyl value of 7–33 and an iodine value of 41–56. The polymer and keto fatty acid contents in the products were up to 2% and 3.2%, respectively. The product can be used in the manufacture of soap as the hard fat component and in textile sizing.
Narrow bandwidth volume holographic optical filter operating at the Kr transition at 1547.82 nm (1994)

We describe and characterize a narrow bandwidth volume holographic optical filter operating at the Krypton transition line (1s2-2p8) at 1547.82 nm, which corresponds to the center wavelength of the proposed International Telecommunications Union wavelength standard. A reflectivity of 98% and a bandwidth full width at half-maximum of 0.18 nm are measured. The filter exhibits clean sideholes with a −20 dB optical response 0.5 nm away from the peak. The filter can be fabricated and operated with an absolute wavelength precision better than 0.005 nm.
Cloning of the hsp70 (dnaK) genes from Rhizobium meliloti and Pseudomonas cepacia: phylogenetic analyses of mitochondrial origin based on a highly conserved protein sequence (1994)

The genes for hsp70 (or dnaK) have been cloned and sequenced from Rhizobium meliloti and Pseudomonas cepacia, two bacterial species belonging to the alpha- and beta-subdivisions of gram-negative proteobacteria, respectively. On the basis of global alignment of HSP70 proteins, several sequence signatures have been identified that are distinctive of mitochondrial homologs and gram-negative proteobacteria on the one hand and the chloroplasts and cyanobacteria on the other. Detailed phylogenetic analyses of HSP70 sequences from various eubacteria and eukaryotic organellar and cytosolic homologs support the inference regarding the origin of mitochondria from a member of the alpha-proteobacteria and of chloroplasts from cyanobacteria. The analysis presented here also suggests a monophyletic origin of the mitochondrial homologs.
Introduction to ion and plasma etching (1976)

This paper is an introduction to dry processing techniques such as ion beam etching, rf sputter etching, and plasma etching. A short description of the systems is followed by a comparison of their properties relevant to the fabrication of electronic and optical devices. The comparison includes etch rates and their dependence on various parameters, masking materials and dimensional accuracy in pattern delineation, obtainable aspect ratios, and edge profiles. The paper concludes with some examples of plasma- and ion-etched patterns.
ACCURATE AND FAST PUPIL LOCALIZATION USING CONTRAST STRETCHING, SEED FILLING AND CIRCULAR GEOMETRICAL CONSTRAINTS (2014)

Iris segmentation is the most contested issue in the iris recognition system, since noise and poor image quality can significantly affect accuracy of iris localization stage. Therefore, very careful attention has to be paid for the segmentation process if only an accurate result is expected. This study presents a new method for precise pupil detection capable of handling the unconstrained bad acquisition conditions especially those related to low contrast or to the non-uniform brightness caused by the position of light sources, specular reflection, eyelashes and eyelids. Contrast stretching (normalization) technique is used for handling the variations in contrast and illumination in an iris image by stretching' the range of intensity values. Next, the local integration is applied on the enhanced image, this process will enhance the contrast level between the existing white and black areas of the image; this will useful to compute the optimal threshold value required to perform a successful image binarization for the purpose of isolation of the pupil region, the seed fill algorithm is used as region growing method to segment the binary image and allocate the pupil as a circular black segment with biggest area, the approximate pupil center is detected then for removing the specular reflection, the pupil is filled with black color using a simple filling method. Finally a circle fitting algorithm is used for precisely allocating the circular pupil region by the fact that richer iris textures are not closer to the pupil boundary. A set of tests was conducted on 2,655 iris images which were downloaded from CASIA V3.0-interval standard dataset; the test results indicated that the proposed method had subjectively 100% accuracy rate with pupil localization, process satisfy the real time constraints even when dealing with images have very different brightness or contrast conditions or they contain eyelashes artifacts.
CASE-based Rigorous Object-Oriented Modeling (1996)

The use of a rigorous development environment is needed when developing a complex system, such as real-time and critical systems. Preventing industry from embracing formal method techniques is the lack of industrial strength tools to support formalization and analysis. We are developing an approach and a tool environment for the development of complex systems that integrates a graphical object-oriented technique (Fusion) and a formal method (Z) with analysis tools. The tool, called FuZE (Fusion/Z Environment), has been used successfully to specify and analyze non-trivial systems. This paper describes the specification transformation rules and the extension of the environment to include transformation of design documents such as Object Interaction Graphs.
Learnable Cost Volume Using the Cayley Representation (2020)

Cost volume is an essential component of recent deep models for optical flow estimation and is usually constructed by calculating the inner product between two feature vectors. However, the standard inner product in the commonly-used cost volume may limit the representation capacity of flow models because it neglects the correlation among different channel dimensions and weighs each dimension equally. To address this issue, we propose a learnable cost volume (LCV) using an elliptical inner product, which generalizes the standard inner product by a positive definite kernel matrix. To guarantee its positive definiteness, we perform spectral decomposition on the kernel matrix and re-parameterize it via the Cayley representation. The proposed LCV is a lightweight module and can be easily plugged into existing models to replace the vanilla cost volume. Experimental results show that the LCV module not only improves the accuracy of state-of-the-art models on standard benchmarks, but also promotes their robustness against illumination change, noises, and adversarial perturbations of the input signals.
Lack of protection following immunisation with<i>H. pylori</i>outer membrane vesicles highlights antigenic differences between<i>H. felis</i>and<i>H. pylori</i> (1998)

Helicobacter pylori-induced inflammation is associated with the development of gastritis, peptic ulcer disease and gastric cancer in humans. Immunisation against this bacterium would ultimately have a major impact on H. pylori-related disease, notably global gastric cancer rates. To date, several potential H. pylori vaccine candidates have been identified. In this study, the Helicobacter felis/murine model was used to assess the immunogenicity of a previously undescribed H. pylori outer membrane vesicle fraction in immune protection.
<i>matB</i> , a Common Fimbrillin Gene of <i>Escherichia coli</i> , Expressed in a Genetically Conserved, Virulent Clonal Group (2001)

A novel fimbrial type in Escherichia coli was identified and characterized. The expression of the fimbria was associated with the O18acK1H7 clonal group of E. coli, which cause newborn meningitis and septicemia when grown at low temperature; hence, it was named the Mat (meningitis associated and temperature regulated) fimbria. The fimbriae were purified from a fimA::cat sfaA::Gm fliC::St derivative of the O18K1H7 isolate E. coli IHE 3034. The purified Mat fimbrillin had an apparent molecular mass of 18 kDa and did not serologically cross-react with the type 1 or S fimbria of the same strain. The matB gene encoding the major fimbrillin was cloned from the genomic DNA of the fimA::cat sfaA::Gm fliC::St derivative of IHE 3034. The predicted MatB sequence was of 195 amino acids, contained a signal sequence of 22 residues, and did not show significant homology to any of the previously characterized fimbrial proteins. The DNA sequence of matB was 97.8% identical to a region from nucleotides 17882 to 18469 in the 6- to 8-min region of the E. coli K-12 chromosome, reported to encode a hypothetical protein. The 7-kb DNA fragment containing matB of IHE 3034 was found by restriction mapping and partial DNA sequencing to be highly similar to the corresponding region in the K-12 chromosome. Trans complementation of the matB::cat mutation in the IHE 3034 chromosome showed that matB in combination with matA or matC restored surface expression of the Mat fimbria. A total of 27 isolates representing K-12 strains and the major pathogroups of E. coli were analyzed for the presence of a matB homolog as well as for expression of the Mat fimbria. A conserved matB homolog was found in 25 isolates; however, expression of the Mat fimbriae was detected only in the O18acK1H7 isolates. Expression of the Mat fimbria was temperature regulated, with no or a very small amount of fimbriae or intracellular MatB fimbrillin being detected in cells cultivated at 37(o)C. Reverse transcriptase PCR and complementation assays with mat genes controlled by the inducible trc promoter indicated that regulation of Mat fimbria expression involved both transcriptional and posttranscriptional events.
AC-DC Converter with Hybrid Three-Level and Two-Level Legs Using Space Vector Modulation for Medium-Voltage SST Applications (2019)

This paper presents a single-phase five-level AC-DC converter with hybrid three-level and two-level legs using space vector modulation for medium-voltage SST application. The hybrid topology combines the low-loss Silicon Carbide (SiC) MOSFET and low-cost IGBT to solve the issues of severe switching-loss of semiconductors, unavailable medium-voltage SiC MOSFET, bulky volume of the inductor and high system cost under medium voltage. The converter reduces the number of active switches and transformers compared to the existing solutions. Moreover, a simple space vector modulation scheme which solves the zero-crossing distortion of presented topology is proposed and verified to realize the smooth transition between switch states for the hybrid topology using a digital signal processor (DSP) instead of FPGA. A 10 kW prototype has been built and verified the topology and modulation scheme.
Implementation of multiple input and multiple output boost converter for electric vehicle charging system (2017)

Limited reservoirs of conventional sources have directed the world for research in non-conventional energy sources. Automobiles is one of the major consumer sector of available conventional energy resources. Due to limited supply and large energy demand, this sector leads to the penetration of hybrid electric vehicle and electric vehicle in automobile engineering. Electric vehicle has the distinguished large charging system. This paper highlights on multi-input and multi-output boost converter which enhances charging system performance of electric vehicle with solar and grid connected sources. This power circuit is reliable interface between different energy forms and battery charging system. Multiple input and output has made the converter more versatile.
Engineering and Material Considerations in Islet Cell Transplantation (1999)

The successful application and optimization of cell transplantation will require quantitative engineering design and analysis of cells and materials in which relevant biological processes remain complex and incompletely defined. This report primarily reviews the engineering and material considerations in islet cell transplantation, including established biological constraints and biohybrid devices for cell delivery, as well as available barrier materials and the associated processing strategies directed at the control of solute transport, barrier permeability, and host responses at the biological-material interface. Also described are current areas of investigation with particular promise as enabling technologies for accelerating the clinical effectiveness of islet cell transplantation.
Setting tables and illustrations with style (1985)

This thesis addresses the problem of formatting complex documents with electronic tools. In particular, the two problems of incorporating illustrations and laying out tables are treated in depth. The notion of style, a way of maintaining consistency in a document, runs throughout the thesis. It helps manage the complexities of formatting both illustrations and tables. The thesis reviews the history of document composition systems, including early computer typesetting systems, document compilers, and integrated document composition systems. The concept of graphical style is introduced to extend the more traditional notion of document style to illustrations. The observation that graphical style does not adequately deal with the layout problem for illustrations leads to the investigation of a more concentrated layout problem for the special case of table formatting. A grid system is used to describe the table layout arrangement and a constraint solver provides the general layout engine for formatting tables as well as the basis for future interactive table design tools. Further research based on the style and table formatting models can be extended to mathematical typesetting and full page layout. A glossary of typesetting terms and an index to the thesis are provided to help the reader deal with the typographic terminology used in the thesis.
Multiscale Edge Detection And Image Segmentation (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
<i>Bordetella pertussis</i>-Infected Human Monocyte-Derived Dendritic Cells Undergo Maturation and Induce Th1 Polarization and Interleukin-23 Expression (2005)

Bordetella pertussis, the causative agent of whooping cough, is internalized by several cell types, including epithelial cells, monocytes, and neutrophils. Although its ability to survive intracellularly is still debated, it has been proven that cell-mediated immunity (CMI) plays a pivotal role in protection. In this study we aimed to clarify the interaction of B. pertussis with human monocyte-derived dendritic cells (MDDC), evaluating the ability of the bacterium to enter MDDC, to survive intracellularly, to interfere with the maturation process and functional activities, and to influence the host immune responses. The results obtained showed that B. pertussis had a low capability to be internalized by-and to survive in-MDDC. Upon contact with the bacteria, immature MDDC were induced to undergo phenotypic maturation and acquired antigen-presenting-cell functions. Despite the high levels of interleukin-10 (IL-10) and the barely detectable levels of IL-12 induced by B. pertussis, the bacterium induced maturation of MDDC and T helper 1 (Th1) polarized effector cells. Gene expression analysis of the IL-12 cytokine family clearly demonstrated that B. pertussis induced high levels of the p40 and p19 subunits of IL-23 yet failed to induce the expression of the p35 subunit of IL-12. Overall our findings show that B. pertussis, even if it survives only briefly in MDDC, promotes the synthesis of IL-23, a newly discovered Th1 polarizing cytokine. A Th1-oriented immune response is thus allowed, relevant in the induction of an adequate CMI response, and typical of protection induced by natural infection or vaccination with whole-cell vaccines.
Some Remarks About Rationality (1977)

*Revised and abbreviated transcript of a talk given at Brockport University College on March 10, 1977.
Cooperative relaying in multi-antenna fixed relay networks (2007)

Space, cost, and signal processing constraints, among others, often preclude the use of multiple antennas at wireless terminals. This paper investigates distributed decode-and-forward fixed relays (infrastructure-based relaying) which are engaged in cooperation in a two-hop wireless network as a means of removing the burden of multiple antennas on wireless terminals. In contrast to mobile terminals, the deployment of a small number of antennas on infrastructure-based fixed relays is feasible, thus, the paper examines the impact of multiple antennas on the performance of the distributed cooperative fixed relays. Threshold-based maximal ratio combining (MRC) and threshold-based selection combining (SC) of these multiple antenna signals are studied and analyzed. It is found that the end-to-end (E2E) error performance of a network which has few relays with many antennas is not significantly worse than that which has many relays each with a fewer antennas. Obviously, the former network has a tremendous deployment cost advantage over the latter. It is also observed that the E2E error performance of a network in which the multiple antennas at relays are configured in SC fashion is not significantly worse than that in which MRC is used. For implementation, SC presents a significantly lower complexity and cost than a full-blown MRC. The analysis in this paper uses the versatile Nakagami fading channels in contrast to the Rayleigh model used in most previous works
Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease (2004)

Borrelia burgdorferi antibodies preferentially present in cerebrospinal fluid (CSF) were examined by differentially probing a B. burgdorferi expression library with CSF and sera from patients with neurologic Lyme disease. Several phage clones selectively reacted with CSF, and these genes were then expressed in recombinant form and used to detect specific antibody in an enzyme-linked immunosorbent assay. Decorin-binding protein B (BBA25) and BBA50 (hypothetical protein) elicited immunoglobulin G (IgG) or IgM detectable in CSF-but not sera-of patients, demonstrating preferential antibody production during neuroborreliosis.
The OAuth Protocol: Web Delegation (2009)

This document specifies the OAuth protocol web delegation method.
OAuth allows clients to access server resources on behalf of another
party (such a different client or an end user). This document defines
a redirection-based user-agent process for end users to authorize
access to clients by substituting their credentials (typically, a
username and password pair) with a different set of delegation-
specific credentials.
Direct C–H Cyanation of Arenes via Organic Photoredox Catalysis (2017)

Methods for the direct C-H functionalization of aromatic compounds are in demand for a variety of applications, including the synthesis of agrochemicals, pharmaceuticals, and materials. Herein, we disclose the construction of aromatic nitriles via direct C-H functionalization using an acridinium photoredox catalyst and trimethylsilyl cyanide under an aerobic atmosphere. The reaction proceeds at room temperature under mild conditions and has proven to be compatible with a variety of electron-donating and -withdrawing groups, halogens, and nitrogen- and oxygen-containing heterocycles, as well as aromatic-containing pharmaceutical agents.
DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells (2007)

Cyclin A1 plays a critical role in hematopoietic malignancies, notably, acute myeloid leukemia. The molecular mechanisms of cyclin A1 action are incompletely understood. Here, we show that cyclin A1 functions are mediated by the retinoblastoma and the Ku70 pathway. High levels of cyclin A1 and the associated CDK2 kinase activity were associated with increasing levels of phosphorylated retinoblastoma in vivo. UV irradiation induced a switch of the CDK2 towards cyclin A1, with accordance to changes in CDK2 kinase activity. The C-terminus of cyclin A1 directly interacted with Ku70, and DNA binding activity of Ku70 was modulated by cyclin A1/CDK2 and phosphatase treatment. Cyclin A1-deficiency induced by shRNA increased apoptosis that is induced by DNA damage and death receptor ligands. Taken together, these analyses demonstrate that cyclin A1 exerts antiapoptotic functions by interacting with retinoblastoma and Ku proteins in leukemia cells.