gebhart/patrepeval huggingface dataset:
Battle Buddies: Rapid Deployment of a Psychological Resilience Intervention for Health Care Workers During the COVID-19 Pandemic (2020)

The outbreak of the coronavirus disease 2019 (COVID-19) and its rapid global spread have created unprecedented challenges to health care systems. Significant and sustained efforts have focused on mobilization of personal protective equipment, intensive care beds, and medical equipment, while substantially less attention has focused on preserving the psychological health of the medical workforce tasked with addressing the challenges of the pandemic. And yet, similar to battlefield conditions, health care workers are being confronted with ongoing uncertainty about resources, capacities, and risks; as well as exposure to suffering, death, and threats to their own safety. These conditions are engendering high levels of fear and anxiety in the short term, and place individuals at risk for persistent stress exposure syndromes, subclinical mental health symptoms, and professional burnout in the long term. Given the potentially wide-ranging mental health impact of COVID-19, protecting health care workers from adverse psychological effects of the pandemic is critical. Therefore, we present an overview of the potential psychological stress responses to the COVID-19 crisis in medical providers and describe preemptive resilience-promoting strategies at the organizational and personal level. We then describe a rapidly deployable Psychological Resilience Intervention founded on a peer support model (Battle Buddies) developed by the United States Army. This intervention-the product of a multidisciplinary collaboration between the Departments of Anesthesiology and Psychiatry & Behavioral Sciences at the University of Minnesota Medical Center-also incorporates evidence-informed "stress inoculation" methods developed for managing psychological stress exposure in providers deployed to disasters. Our multilevel, resource-efficient, and scalable approach places 2 key tools directly in the hands of providers: (1) a peer support Battle Buddy; and (2) a designated mental health consultant who can facilitate training in stress inoculation methods, provide additional support, or coordinate referral for external professional consultation. In parallel, we have instituted a voluntary research data-collection component that will enable us to evaluate the intervention's effectiveness while also identifying the most salient resilience factors for future iterations. It is our hope that these elements will provide guidance to other organizations seeking to protect the well-being of their medical workforce during the pandemic. Given the remarkable adaptability of human beings, we believe that, by promoting resilience, our diverse health care workforce can emerge from this monumental challenge with new skills, closer relationships, and greater confidence in the power of community.
Neurometabolic Functioning and Neuropsychological Correlates in Children With ADHD-H: Preliminary Findings (2004)

Proton magnetic resonance spectroscopy (MRS) and neuropsychological testing were conducted on 8 children with attention-deficit/hyperactivity disorder (ADHD-H), with no learning disabilities or comorbidities and 8 controls. Magnetic resonance spectroscopy revealed increased Glutamate/Glutamine in both frontal areas, and increased N-acetyl aspartate and Choline in the right frontal area of the ADHD-H subjects. Neuropsychological testing revealed few within- and between-group differences. Findings related to frontal lobe dysfunction in ADHD-H subjects were noted. N-acetylasparte/creatine (NAA/Creatine) in the right frontal region, and myoinositol/creatine (Myo inositol/Creatine) in the right and left frontal regions appear to be highly associated with the regulation of sensorimotor, language, and memory and learning functioning in children with ADHD-H.
Unique Poetry on Five Ragamala Paintings in the National Gallery of Victoria: Rhyme, Alliteration and Rhythm in Couplets of Great Intensity and Charm (2007)

The key aspects and features of the five couplets of unique poetry inscribed on five Ragamala paintings in the National Gallery of Victoria are discussed. The poems illustrate the creative genius of a poet gifted with an unusual talent for combining words and also reveal the work of a poet simultaneously acutely sensitive to musical aesthetics.
브랜드 위기의 유형이 브랜드 태도에 미치는 부정적 영향에 관한 연구 (2011)

브랜드는 기업이 가질 수 있는 가장 강력한 경쟁수단의 하나라는 인식이 빠른 속도로 확산되고 있다. 이와 함께 기업들은 그들의 브랜드를 키우고 강화하기 위해 긍정적인 여러 정보들을 소비자에게 전달하는데 많은 노력을 기울이고 있다. 하지만 소비자들은 브랜드에 대한 긍정적인 정보에만 노출되는 것은 아니다. 소비자가 어떤 브랜드에 대한 부정적인 정보에 노출되었을 경우, 그 심각도에 따라 브랜드 자산에 치명적인 악영향을 미칠 수도 있게 되며, 결국 그동안 쌓아온 브랜드 자산이 한순간에 무너지는 브랜드 위기를 초래하게 될 수 있는 것이다. 브랜드 위기는 기존 연구에서 제시된 제품 위기의 확장된 개념으로서, 진실이건 진실이 아니건 어떤 브랜드에 대한 부정적인 정보의 확산으로 인해 해당 브랜드의 자산적 가치에 손상이 발생될 수 있는 상황을 말한다. 따라서 기업은 브랜드 자산을 구축하기 위한 여러 노력들도 중요하지만, 축적된 자산적 가치를 보존하기 위한 노력 역시 그에 못지않게 중요하며, 브랜드의 가치를 감소시킬 수 있는 어떤 부정적 사건이나 정보가 나타났을 경우 이에 어떻게 대응하는 것이 가장 효과적일 것인지에 대한 고민 역시 필요하다. 일반적으로 기존의 브랜드 위기에 관한 연구들은 브랜드 위기를 초래하는 상황에 대해 포괄적으로 접근하였으며, 그 상황을 유형화 하여 각 유형별 브랜드 위기의 파급효과가 어떻게 차별적으로 나타나는지 등의 보다 심층적인 접근이 부족했었다. 예를 들어, 최근 토요타 자동차의 브랜드 위기는 그 기업에서 생산한 자동차의 기능적 결함에서 비롯된 것이다. 즉, 제품 품질 등의 기업 역량(corporate ability: 이하 CA)과 관련된 이미지에 악영향을 주는 사건이 발생한 것이다. 반면, 과거 나이키의 베트남 공장에서의 노동착취에 대한 기사나, 스타벅스가 농부들의 원두커피 값을 비정상적으로 거래한 사실이 언론에 공개된 경우는 이들 기업의 제품 품질이나 기술력과 같은 기업 역량 측면에서의 부정적인 사건이 발생한 것이 아니라 그 기업의 사회적 책임(corporate social responsibility: 이하 CSR)과 관련된 이미지에 타격을 주는 정보가 나타난 것이다. 이처럼 브랜드 위기를 발생시킨 상황은 항상 동질적인 것이 아니며, 그에 따라 소비자들의 반응 역시 차별적으로 나타날 수 있는 것이다. 마찬가지로 기업의 대응방식도 위기의 유형에 따라 다르게 전개되는 것이 효과적일 수 있는 것이다. 따라서 본 연구에서는 브랜드 위기의 유형을 CA 차원과 관련된 위기와 CSR 차원과 관련된 위기로 유형화하고, 이러한 위기의 유형에 따라 소비자의 반응이 어떻게 차별적으로 나타나는지를 연구하였다. 또한 이러한 소비자의 차별적 반응에 조절적인 역할을 하는 변수로서 브랜드 계층구조(기업 브랜드 vs. 제품 브랜드), 개인의 자기관(독립적 자기관 vs. 상호의존적 자기관)의 영향을 살펴보았다. 본 연구의 결과는 다음과 같다. 첫째, CA 차원의 브랜드 위기가 발생했을 경우 CSR 차원의 브랜드 위기가 발생했을 경우에 비해 그 브랜드에 대한 부정적인 영향력이 크게 나타났다. 둘째, 브랜드 위기의 유형별 소비자 반응의 차이는 대상 브랜드의 수준에 따라 다르게 나타났다. 구체적으로는, 개별 브랜드 차원에서 브랜드 위기가 발생하였을 경우에는 대상 브랜드에 미치는 부정적 영향이 브랜드 위기의 유형에 따라 다르게 나타났으나, 즉, 기업의 역량 관련 위기일 경우가 기업의 사회적 책임관련 위기일 경우보다 크게 나타났으나, 기업 브랜드 차원에서 브랜드 위기가 발생하였을 경우에는 브랜드 위기의 유형 간의 의미 있는 차이가 나타나지 않았다. 셋째, 소비자의 자기관은 그들의 위기 유형별 반응에 영향을 주었다. 독립적 자기관을 가진 소비자는 브랜드 위기의 유형이 기업의 사회적 책임 관련인 경우보다 역량 관련인 경우에 더 부정적인 반응이 나타났으나, 상호의존적 자기관을 가진 소비자는 브랜드 위기의 유형에 따른 차이가 나타나지 않음을 알 수 있었다. 끝으로, 본 연구를 통해 얻을 수 있는 이론적 및 실무적 시사점을 살펴보았으며, 한계점 및 향후 연구방안에 대해 논의하였다.
Inhibitors of clathrin-dependent endocytosis enhance TGFβ signaling and responses (2009)

Clathrin-dependent endocytosis is believed to be involved in TGFbeta-stimulated cellular responses, but the subcellular locus at which TGFbeta induces signaling remains unclear. Here, we demonstrate that inhibitors of clathrin-dependent endocytosis, which are known to arrest the progression of endocytosis at coated-pit stages, inhibit internalization of cell-surface-bound TGFbeta and promote colocalization and accumulation of TbetaR-I and SARA at the plasma membrane. These inhibitors enhance TGFbeta-induced signaling and cellular responses (Smad2 phosphorylation/nuclear localization and expression of PAI-1). Dynasore, a newly identified inhibitor of dynamin GTPase activity, is one of the most potent inhibitors among those tested and, furthermore, is a potent enhancer of TGFbeta. Dynasore ameliorates atherosclerosis in the aortic endothelium of hypercholesterolemic ApoE-null mice by counteracting the suppressed TGFbeta responsiveness caused by the hypercholesterolemia, presumably acting through its effect on TGFbeta endocytosis and signaling in vascular cells.
Size-Dependent Surface Plasmon Resonance Broadening in Nonspherical Nanoparticles: Single Gold Nanorods (2013)

The dependence of the spectral width of the longitudinal localized surface plasmon resonance (LSPR) of individual gold nanorods protected by a silica shell is investigated as a function of their size. Experiments were performed using the spatial modulation spectroscopy technique that permits determination of both the spectral characteristics of the LSPR of an individual nanoparticle and its morphology. The measured LSPR is shown to broaden with reduction of both the nanorod length and its diameter, which is in contrast with the predictions of existing classical and quantum theoretical models. This behavior can be reproduced assuming the LSPR width linearly depends on the inverse of an effective length proportional to the square root of the particle surface with the same slope as that recently determined for silica-coated silver nanospheres.
Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases (1991)

Human polymorphonuclear leukocytes (PMN) activated by fMLP (in the presence of CaCl2, fibrinogen, and cytochalasin B) were able to induce aggregation, cytoplasmic Ca2+ increase, and thromboxane A2 production in coincubated autologousplatelets. Cell-free supernatants prepared from n-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated PMN were able also to induce platelet activation. Antibodies against cathepsin G and different serin protease inhibitors completely suppressed the activity of PMN-derived supernatants, indicating that cathepsin G is the major platelet activator released by PMN in our system. However, antiproteinases only partially affected platelet activation induced by PMN in mixed cell suspensions. Superoxide dismutase and catalase added to the cell suspension did not affect platelet activation nor potentiated serin protease inhibitors, making a role for short-lived oxygen radicals in our experimental system unlikely. Electron microscopic observation of stirred mixed cell suspensions preincubated for 2 minutes at 37 degrees C before stimulation showed a close PMN- platelets contact without any morphologic or biochemical event suggesting platelet activation. Preincubation of the cells without stirring to minimize PMN-platelet interaction before stimulation did not modify subsequent aggregation and platelet cytoplasmic Ca2+ increase in control samples. However, in this condition trypsin inhibitor from soybean completely prevented PMN-induced platelet activation. In samples preincubated without stirring in the presence of the antiproteinase, activated PMN stuck together but platelets preserved their discoid shape and did not appear significantly activated. We propose that membrane-to-membrane contact could create a microenvironment in which cathepsin G, discharged from stimulated PMN on adherent platelets, is protected from antiproteinases.
Cultured endothelial cell monolayers that restrict the transendothelial passage of macromolecules and electrical current (1984)

Bovine microvascular endothelial cells (BMECs) proliferated to confluence on the stromal surface of human amniotic membrane that had been denuded of its natural epithelium. The resulting cultures had the following characteristics: (a) The endothelial cells formed a thin, continuous monolayer and, like their in vivo counterparts, contained basal adhesion plaques and large numbers of cytoplasmic vesicles and 10-nm filaments. In addition, the endothelial cells elaborated a basement membrane-like structure. (b) The borders of the BMECs reacted with AgNO3 to produce the "flagstone" pattern typical of endothelium stained with this reagent in vivo. (c) More than 90% of the zones of contact between endothelial cells examined 8 d after plating prevented passage of a macromolecular probe (wheat germ agglutinin conjugated to horseradish peroxidase) across the BMEC monolayer. (d) 8 d-old cultures displayed a transendothelial electrical resistance that averaged 69 +/- 28 omega X cm2. Monolayers of BMECs maintained on amnion thus resemble in vivo endothelium in several respects and should provide a useful and relevant model for the in vitro study of various phenomena that occur at the microvascular wall.
Segmented bimorph deformable mirror (1989)

The efficient low-voltage bending properties of PZT bimorph wafers have been combined with conventional microelectronics techniques to produce a 37-hex-faceted deformable mirror 23 mm in diameter and 1 mm thick. Despite the high ratio of diameter to thickness, at 633 nm an overall flatness of better than one-half wave peak-to-valley (PV) and one-tenth wave RMS is attained under an active figure control of about 7 V per wave. Evaporative deposition of the electrical contact pattern eliminates mechanical coupling to the bimorph and allows the device to perform to frequencies in excess of 10 kHz.
Comparison of Some Tests of Fit for the Inverse Gaussian Distribution (2012)

This paper gives an empirical investigation of some tests of goodness of fit for the inverse Gaussian distribution.
Al<sub>0.17</sub>Ga<sub>0.83</sub>N Film Using Middle-Temperature Intermediate Layer Grown on (0001) Sapphire Substrate by Metal-Organic Chemical Vapor Deposition (2007)

The reduction of the dislocation density in a high-temperature (HT)-Al0.17Ga0.83N epitaxial layer was achieved by a middle-temperature (MT)-intermediate layer technique, in which the HT and the MT were 1050 and 950 °C, respectively. For one set of the MT-intermediate layer, the structure was 4.5-µm-thick HT-Al0.17Ga0.83N/1-µm-thick MT-intermediate layer/100-nm-thick HT-Al0.17Ga0.83N layer/low-temperature (LT)-GaNP buffer/trenched (0001) sapphire. The full-width at half maximum values of (0002) and (1012) diffraction peaks of the X-ray diffraction for the Al0.17Ga0.83N epitaxial layer using one set of the MT-intermediate layer were improved to 359 and 486 arcsec compared with 401 and 977 arcsec for the film without the MT-intermediate layer technique, respectively. Transmission electron microscopy result showed that the dislocation density in the Al0.17Ga0.83N film using one set of MT-intermediate layer was reduced from (1–4)×1010 to 1.7×109 cm-2. The Al0.17Ga0.83N epitaxial film including two sets of MT-intermediate layers improved the most, showing a dislocation density of 9.3×108 cm-2.
A New Testament Understanding of the Jewish Rejection of Jesus: Four Theologians on the Salvation of Israel (2000)

Is Christian theology inherently anti-Semitic? Are the fundamental teachings of the NT blatantly anti-Jewish? Is the church’s historical oppression of Judaism responsible (at least in part) for the Holocaust? More importantly, does the Holocaust force Christians to re-think the matter of Jewish salvation? A growing number of scholars, both Jewish and Christian, are answering “Yes” to these questions, and are seeking alternative understandings of the Christian message which they believe will avoid the antiSemitic trappings of the past. The landmark work in this area is Rosemary Ruether’s Faith and Fratricide , which was published in 1974. This book examined how Judaism has been demeaned and vili ed by the NT, the Church fathers, and the states of Christian Europe. Ruether called for a radical new openness on the part of Christians toward Judaism in order to make amends for these sins: “Christians must be able to accept the thesis that it is not necessary for Jews to have the story about Jesus in order to have a foundation for faith and a hope for salvation.” 1 The solution to Christian anti-Judaism, Ruether claimed, lies in a “revitalization of Christian absolutism which can accept the independent salvi c validity of the Jewish tradition.” 2 Ruether’s book has had a tremendous in uence on the contemporary Jewish-Christian dialogue. The extent of this in uence can be judged from the fact that Gregory Baum, who wrote a powerful apologetic work in 1968 vigorously defending the NT against the charge of anti-Semitism, penned the introduction to 1974’s Faith and Fratricide . He there admitted that the apology he presented in his earlier work was untenable. 3 Baum stated he had come to believe that, in light of the history of Christian anti-Judaism, especially the Holocaust, Christian theologians must “look for a formulation of the Christian faith that does not negate Jewish existence.” 4 Baum is not alone in his abrupt change of position. For example, Krister Stendahl no longer believes that Paul’s letter to the Romans teaches that Jews must receive Christ as their Savior in order to experience salvation. 5
Voluntary Disclosure of Private Information and Unraveling in the Market for Lemons: An Experiment (2018)

We experimentally analyze a lemons market with a labor-market framing. Sellers are referred to as “workers” and have the possibility to provide “employers” with costly but credible information about their “productivity”. Economic theory suggests that in this setup, unraveling takes place and a number of different types are correctly identified in equilibrium. While we do observe a substantial degree of information disclosure, we also find that unraveling is typically not as complete as predicted by economic theory. The behavior of both workers and employers impedes unraveling in that there is too little disclosure. Workers are generally reluctant to disclose their private information, and employers enforce this behavior by bidding less competitively if workers reveal compared to the case where they conceal information.
The role of PAMPs and DAMPs in the pathogenesis of acute and recurrent anterior uveitis (2009)

The pathogenesis of acute and recurrent anterior uveitis is poorly understood. Here, recent evidence is presented for the hypothesis that this disease may be associated with activation of receptors of the innate immune system, such as Toll-like receptors, by pathogen associated molecule patterns, such as lipopolysaccharide, derived from triggering gram negative bacteria. Acute anterior uveitis results in ocular tissue damage and the release of endogenous molecules (damage associated molecular patterns), such as heat shock proteins and S100 proteins that can also activate Toll-like receptors and thus perpetuate or reactivate intraocular inflammation.
A 3D aligning method for stimulated emission depletion microscopy using fluorescence lifetime distribution (2014)

Optimal resolution by stimulated emission depletion (STED) microscopy requires precise alignment of the donut-shaped depletion focus to the excitation focus. In this article, we demonstrate that fluorescence lifetime distribution can be implemented to align the STED system. Different from the traditional aligning methods in which a scattering imaging module is often equipped, the lifetime-based method is free from probable mismatches between the scattering mode and the fluorescent mode, drift errors caused by separate imaging and complex fitting methods. Based on this method, a spatial resolution of 38 nm by time-gated detection has been achieved.
Ultraviolet B Wavelength Dependence for the Regulation of Two Major Matrix‐Metalloproteinases and Their Inhibitor TIMP‐1 in Human Dermal Fibroblasts (1996)

The wavelength dependence for the regulation of two major matrix-metalloproteinases, interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3), and their major inhibitor, tissue inhibitor of metalloproteinases (TIMP-1), was studied in human dermal fibroblasts in vitro. Monochromatic irradiation at 302, 307, 312 and 317 nm with intensities ranging from 20 to 300 J/m2 increased MMP-1 and MMP-3 mRNA steady-state levels and the secretion of the corresponding proteins up to 4.4-fold, whereas almost no increase was observed at wavelengths < 290 nm. In contrast, the synthesis of TIMP-1 increased only marginally. This imbalance may contribute to the severe connective tissue damage related to photoaging of the skin. The wavelengths responsible for MMP-1 and MMP-3 induction reported here are distinct from the absorption spectrum of DNA and are different from results previously reported in the literature. Importantly, they overlap with wavelengths whose intensity is predicted to increase on the earth's surface upon ozone depletion. Intensities and particular wavelengths used in our studies in vitro can be absorbed readily by fibroblasts within the skin in vivo and, thus, are relevant for risk assessment and development of protective agents.
Integrins Modulate Fast Excitatory Transmission at Hippocampal Synapses (2003)

The present study provides the first evidence that adhesion receptors belonging to the integrin family modulate excitatory transmission in the adult rat brain. Infusion of an integrin ligand (the peptide GRGDSP) into rat hippocampal slices reversibly increased the slope and amplitude of excitatory postsynaptic potentials. This effect was not accompanied by changes in paired pulse facilitation, a test for perturbations to transmitter release, or affected by suppression of inhibitory responses, suggesting by exclusion that alterations to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-type glutamate receptors cause the enhanced responses. A mixture of function-blocking antibodies to integrin subunits alpha(3), alpha(5), and alpha(v) blocked ligand effects on synaptic responses. The ligand-induced increases were (i) blocked by inhibitors of Src tyrosine kinase, antagonists of N-methyl-d-aspartate receptors, and inhibitors of calcium calmodulin-dependent protein kinase II and (ii) accompanied by phosphorylation of both the Thr(286) site on calmodulin-dependent protein kinase II and the Ser(831) site on the GluR1 subunit of the AMPA receptor. N-Methyl-d-aspartate receptor antagonists blocked the latter two phosphorylation events, but Src kinase inhibitors did not. These results point to the conclusion that synaptic integrins regulate glutamatergic transmission and suggest that they do this by activating two signaling pathways directed at AMPA receptors.
Modulation of Cellular Iron Metabolism by Hydrogen Peroxide (2001)

Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin. Under conditions of iron starvation, both IRP1 and IRP2 bind with high affinity to cognate IREs, thus stabilizing TfR and inhibiting translation of ferritin mRNAs. The IRE/IRP regulatory system receives additional input by oxidative stress in the form of H(2)O(2) that leads to rapid activation of IRP1. Here we show that treating murine B6 fibroblasts with a pulse of 100 microm H(2)O(2) for 1 h is sufficient to alter critical parameters of iron homeostasis in a time-dependent manner. First, this stimulus inhibits ferritin synthesis for at least 8 h, leading to a significant (50%) reduction of cellular ferritin content. Second, treatment with H(2)O(2) induces a approximately 4-fold increase in TfR mRNA levels within 2-6 h, and subsequent accumulation of newly synthesized protein after 4 h. This is associated with a profound increase in the cell surface expression of TfR, enhanced binding to fluorescein-tagged transferrin, and stimulation of transferrin-mediated iron uptake into cells. Under these conditions, no significant alterations are observed in the levels of mitochondrial aconitase and the Divalent Metal Transporter DMT1, although both are encoded by two as yet lesser characterized IRE-containing mRNAs. Finally, H(2)O(2)-treated cells display an increased capacity to sequester (59)Fe in ferritin, despite a reduction in the ferritin pool, which results in a rearrangement of (59)Fe intracellular distribution. Our data suggest that H(2)O(2) regulates cellular iron acquisition and intracellular iron distribution by both IRP1-dependent and -independent mechanisms.