gebhart/patrepeval huggingface dataset:
Surface Modification of Thermal Sprayed Coatings (1996)

Abstract Thermal sprayed coatings are frequently used in corrosive environments, even when their major purpose is to provide wear or thermal resistance, rather than corrosion resistance. This includes Thermal Barrier Coatings (TBC), where high porosity is a desired feature to give good thermal protection. However, as this proves to be a limiting factor in the corrosion protection, a trade off is involved. This is because the interconnected porosity in TBCs allows the corrosive media to reach the coating-substrate interface, which eventually leads to delamination of the coatings. This work addresses the problem of permeability of TBCs which can lead to premature delamination due to interfacial corrosion. The coatings studied were yttria-stabilized zirconia TBCs. A simple infiltration technique has been proposed using sol-gel ceramic precursors. The precursors studied include aluminum isopropoxide or pre-hydrolyzed ethyl silicate, which decomposed to alumina and silica respectively, at surface heat treatment temperatures as low as 550°C. In addition to sealing the surface, it is believed that some level of compressive stress is generated on the surface of TBCs on cooling from the processing temperature. Electrochemical tests in 3.0% NaCl have been carried out to study the effectiveness of the sealant. These potentiodynamic tests as well as permeability tests show a considerable decrease in interconnected porosity with sol-gel modifications of the coatings.
Online object recognition by MSER trajectories (2008)

This work presents a robust online learning and recognition system. The basic idea is to exploit information from tracking an object during the recognition and/or learning stage to obtain increased robustness and better recognition results. Object tracking by means of an extended MSER tracker is utilized to detect local features and construct their trajectories. Compact object representations are formed by summarizing the trajectories. All steps are performed online including the MSER detection, tracking, summarization, SIFT description as well as learning and recognition based on a vocabulary tree. The proposed method is evaluated on realistic video sequences which prove the increased performance for robust online recognition.
Interleukin-10–Secreting “Regulatory” T Cells Induced by Glucocorticoids and β2-Agonists (2005)

Greater clinical benefit in controlling the symptoms of asthma is frequently observed through combining moderate doses of inhaled glucocorticoids together with long-acting beta(2)-agonists, as compared with increasing glucocorticoid dosage alone. To address in vitro whether glucocorticoids plus beta(2)-agonists, compared with glucocorticoids alone, have greater inhibitory activity on CD4+ T cell responses to allergen, peripheral blood CD4+ T cell responses to allergen were compared in the presence or absence of the glucocorticoid fluticasone proprionate and the short- and long-acting beta(2)-agonists salbutamol and salmeterol, respectively. Fluticasone proprionate inhibited interleukin (IL)-5 and IL-13 and enhanced IL-10 synthesis in allergen-stimulated cultures in a concentration-dependent manner. Salmeterol, but not salbutamol, inhibited IL-5 and IL-13 and enhanced IL-10 synthesis in these cultures. When used in combination the two drugs demonstrated an additive effect on this pattern of cytokine production. Allergen-specific T cell lines induced in the presence of salmeterol and fluticasone proprionate inhibited IL-5 and IL-13 production by allergen-specific Th2 cell lines in an IL-10-dependent manner. Thus fluticasone proprionate and salmeterol increased IL-10 and reduced Th2 cytokine synthesis additively in allergen stimulated human CD4+ T cells.
Ultrasensitive in Situ Label-Free DNA Detection Using a GaN Nanowire-Based Extended-Gate Field-Effect-Transistor Sensor (2011)

In this study, we have successfully demonstrated that a GaN nanowire (GaNNW) based extended-gate field-effect-transistor (EGFET) biosensor is capable of specific DNA sequence identification under label-free in situ conditions. Our approach shows excellent integration of the wide bandgap semiconducting nature of GaN, surface-sensitivity of the NW-structure, and high transducing performance of the EGFET-design. The simple sensor-architecture, by direct assembly of as-synthesized GaNNWs with a commercial FET device, can achieve an ultrahigh detection limit below attomolar level concentrations: about 3 orders of magnitude higher in resolution than that of other FET-based DNA-sensors. Comparative in situ studies on mismatches ("hotspot" mutations related to human p53 tumor-suppressor gene) and complementary targets reveal excellent selectivity and specificity of the sensor, even in the presence of noncomplementary DNA strands, suggesting the potential pragmatic application in complex clinical samples. In comparison with GaN thin film, NW-based EGFET exhibits excellent performance with about 2 orders higher sensitivity, over a wide detection range, 10(-19)-10(-6) M, reaching about a 6-orders lower detection limit. Investigations illustrate the unique and distinguished feature of nanomaterials. Detailed studies indicate a positive effect of energy band alignment at the biomaterials-semiconductor hybrid interface influencing the effective capacitance and carrier-mobility of the system.
Antibodies against glycosphingolipids in sera of patients with idiopathic thrombocytopenic purpura (1987)

Evidence is presented for the existence of antibodies against platelet glycosphingolipids in sera of patients with chronic idiopathic thrombocytopenic purpura and antiplatelet antibodies. Increased binding of IgG/IgM to neutral glycosphingolipids or gangliosides extracted from donor platelets was measured by an ELISA in 17 sera of 30 patients. Thirteen sera, five with anticardiolipin antibodies, demonstrated an increased binding to sulphatides confirmed by immuno HPTLC. Four sera showed reactivity with the platelet minor gangliosides established by immuno-HPTLC.
Tipifarnib and tanespimycin show synergic proapoptotic activity in U937 cells (2011)

Our results suggest that the combination of R115777 + 17AAG could be useful in treating some of the hematological malignancies.
Saturated-absorption spectroscopy of weak-field Zeeman splittings in rubidium (1995)

Using an external cavity-tuned diode laser in Doppler-free saturation spectroscopy, we are able to resolve the weak-field Zeeman splittings in the hyperfine levels of the rubidium D1 line. The number of lines observed in the Zeeman structure of rubidium and their measured energy-level splittings are as expected from theory. The measured amplitudes of the saturated-absorption signals, crossover resonances, and velocity-selective optical pumping signals are used in the analysis of various theories concerning saturated-absorption spectroscopy.
Performance Characteristics of the BluePrint® Breast Cancer Diagnostic Test (2020)

The analytical performance of a multi-gene diagnostic signature depends on many parameters, including precision, repeatability, reproducibility and intra-tumor heterogeneity. Here we study the analytical performance of the BluePrint 80-gene breast cancer molecular subtyping test through determination of these performance characteristics. BluePrint measures the expression of 80 genes that assess functional pathways which determine the intrinsic breast cancer molecular subtypes (i.e. Luminal-type, HER2-type, Basal-type). Knowing a tumor's dominant functional pathway can help allocate effective treatment to appropriate patients. Here we show that BluePrint is a highly precise and highly reproducible test with correlations above 98% based on the generated index and subtype concordance above 99%. Therefore, BluePrint can be used as a robust and reliable tool to identify breast cancer molecular subtypes.
Targeting DNA Mismatches with Rhodium Intercalators Functionalized with a Cell-Penetrating Peptide (2006)

Cell-penetrating peptides are widely used to deliver cargo molecules into cells. Here we describe the synthesis, characterization, DNA binding, and cellular uptake studies of a series of metal-peptide conjugates containing oligoarginine as a cell-penetrating peptide. d-Octaarginine units are appended onto a rhodium intercalator containing the sterically expansive chrysenequinone diimine (chrysi) ligand to form Rh(chrysi)(phen)(bpy)(3+)-tethered oligoarginine conjugates, where the peptide is attached to the ancillary bpy ligand; some conjugates also include a fluorescein or thiazole orange tag. These complexes bind and with photoactivation selectively cleave DNA neighboring single-base mismatches. The presence of the oligoarginines is found to increase the nonspecific binding affinity of the complexes for both matched and mismatched DNA, but for these conjugates, photocleavage remains selective for the mismatched site, as assayed using both gel electrophoresis and mass spectrometry experiments. Significantly, the rhodium complex does not interfere with the delivery properties of the cell-penetrating peptide. Confocal microscopy experiments show rapid nuclear localization of the metal-peptide conjugates containing the tethered fluorescein. Mass spectrometry experiments confirm the association of the rhodium with the HeLa cells. These results provide a strategy for targeting mismatch-selective metal complexes inside cell nuclei.
Effect of core topology on projectile penetration in hybrid aluminum/alumina sandwich structures (2013)

A series of hybrid sandwich structures were fabricated by shrink-fitting precision-ground prisms of alumina (CoorsTek grade AD 995) with triangular, trapezoidal or rectangular cross-sections into the voids of extruded sandwich panels made from Al 6061-T6. The panels were subjected to impact tests using hard steel spheres over the velocity range 570–1800 m s−1. A combination of X-ray tomography, high-speed video imaging and cross sectioning of impacted samples was used to investigate the penetration mechanisms. We find that the ballistic performance of these structures, characterized by the ballistic limit and the exit velocity of impact ejecta beyond this limit, is significantly improved when triangular prisms are replaced by trapezoidal prisms, provided the base width of the prism exceeds about three times the projectile diameter. Additional performance improvements are obtained when the trapezoidal prisms are replaced by rectangular prisms, albeit at the expense of an increase in the lateral extent of damage. The variations in impact response are found to arise from: (i) the effect of prism size and shape on the degree of confinement of the ceramic by the metallic webs, (ii) the core web structure, which influences the fracture conoid angle in the transverse plane, and (iii) the spacing of web-face nodes on the back face, which governs the deflection and fracture of the back-face sheet.
Distance-dependent quenching and enhancing of electrochemiluminescence from a CdS:Mn nanocrystal film by Au nanoparticles for highly sensitive detection of DNA (2009)

The quenching of electrochemiluminescence (ECL) from a CdS:Mn nanocrystal film by proximal Au nanoparticles was observed as a result of Förster energy transfer, while an enhancement of ECL takes place after hybridization with target DNA due to the energy transfer of ECL excited surface plasmon resonances in AuNPs to the CdS:Mn NCs at large separation, based on which an ultrasensitive and specific DNA biosensor was constructed.
Fluoride retention of Atlantic salmon (Salmo salar) fed krill meal (2004)

The present experiment was performed to study how fluoride from krill meal enriched muscle, whole fish and bone of adult Atlantic salmon (Salmo salar) reared in sea water. Atlantic salmon (mean weight 0.5 kg) were divided into four triplicate groups and fed a commercial fish meal based diets with 0, 100, 200 and 300 g krill kg−1 feed, respectively, for 12 weeks. The fluoride concentrations in the experimental feeds were analysed to be 18, 132, 235 and 358 mg kg−1, respectively. Growth, mortality and feed efficiency were recorded through the experiment. Fluoride concentration was measured in muscle, whole-body, and bone initially and after 12 weeks of feeding. The fluoride concentrations in the samples were determined by alkali fusion and fluoride ion-selective electrode. Growth, mortality and feed efficiency ratio were not affected by the dietary treatments. The results showed that fluoride concentration in muscle, whole body and bone were not affected by the dietary fluoride level. The fluoride concentration in the tissues showed great variation among replicates of the group given the same diet. Fillets of the fish varied between 0.3 and 1.4 mg fluoride kg−1 wet weight, whereas the whole-body concentration of fluoride varied between 3.3 and 6.1 mg kg−1 wet weight and the fluoride bone concentration varied between 5.8 and 7.2 mg kg−1 fresh weight. These results suggest that Atlantic salmon are highly tolerant of dietary fluoride given as krill meal with concentration of fluoride up to 350 mg kg−1 diet, and that accumulation of fluoride from feeding diets containing krill meal does not lead to tissue accumulation in the fish, at least over a short period of time.
Characteristics and Novel Features of Thermostable α‐Amylase Produced by <i>Bacillus licheniformis</i> M27 under Solid State Fermentation (1990)

Abstract The purified α‐amylase from Bacillus licheniformis M27, produced under solid state fermentation technique, showed novel characteristics as compared to those reported by other workers for the purified α‐amylases from B. licheniformis obtained by submerged fermentation process. Some of the novel features of the characteristics of the enzyme from B. licheniformis M27 include two peaks for pH optima at 6.5–7.0 and 8.5–9.0, gradual loss of activity to about 86% between pH 7.0–7.5 followed by rise to full activity between 7.5–8.5, temperature optimum at 85–90°C at pH 7.0 and 9.0, sharp fall in stability at acidic pH values and the thermostability response which is more similar to the enzyme from other species of Bacillus . The moleculuar weight of the enzyme was found to be 19,500 ± 500 and 56,000 ± 2,000 when determined by gel filtration and SDS PAGE, respectively. The activation energy is 20.4 times lower than that reported for the enzyme from another strain of B. licheniformis . It also showed differences in the contents of amino acids such as serine, proline and methionine.
F-CNN: An FPGA-based framework for training Convolutional Neural Networks (2016)

This paper presents a novel reconfigurable framework for training Convolutional Neural Networks (CNNs). The proposed framework is based on reconfiguring a streaming datapath at runtime to cover the training cycle for the various layers in a CNN. The streaming datapath can support various parameterized modules which can be customized to produce implementations with different trade-offs in performance and resource usage. The modules follow the same input and output data layout, simplifying configuration scheduling. For different layers, instances of the modules contain different computation kernels in parallel, which can be customized with different layer configurations and data precision. The associated models on performance, resource and bandwidth can be used in deriving parameters for the datapath to guide the analysis of design trade-offs to meet application requirements or platform constraints. They enable estimation of the implementation specifications given different layer configurations, to maximize performance under the constraints on bandwidth and hardware resources. Experimental results indicate that the proposed module design targeting Maxeler technology can achieve a performance of 62.06 GFLOPS for 32-bit floating-point arithmetic, outperforming existing accelerators. Further evaluation based on training LeNet-5 shows that the proposed framework achieves about 4 times faster than CPU implementation of Caffe and about 7.5 times more energy efficient than the GPU implementation of Caffe.
Encapsulation of biologics in self‐assembled fibers as biostructural units for tissue engineering (2004)

The concept of a "biostructural unit" is presented as the combination of biological and structural building blocks to create scaffolds or constructs via a bottom-up approach. Three types of biostructural units were constructed using the process of fiber formation by interfacial polyelectrolyte complexation: protein-encapsulated fiber, ligand-immobilized fiber, and cell-encapsulated fiber units. Water-soluble chitin (WSC) and alginate were used as the polyelectrolyte combination to form fiber. Encapsulation and sustained release of bovine serum albumin from the fiber could be achieved, release profiles being dependent on the WSC/alginate concentration ratio. Released nerve growth factor (NGF) retained its bioactivity, as demonstrated on PC12 cells. Biotinylated fiber could be fabricated by biotinylating alginate before drawing fiber with WSC, enabling biotinylated NGF to be immobilized to fiber via an avidin bridge. The immobilized NGF induced the differentiation of PC12 cells seeded on the fiber. Bovine pulmonary endothelial cells, human dermal fibroblasts, and human mesenchymal stem cells were encapsulated, demonstrating good viability as determined by Live/Dead and WST-1 assays. The assembly of biostructural units into constructs was illustrated by using human mesenchymal stem cell-encapsulated fiber units. Cells in the resulting constructs could be induced to differentiate along chondrogenic and osteogenic lineages.
High power electrically pumped VECSELs and arrays (2014)

VECSELs are characterized by an outstanding brightness of 100kW/mm²/sr and a small spectral width. Electrical pumping and the potential to combine many emitters in arrays allow for highly integrated and easy to manufacture laser sources which can be scaled towards high power. This almost ideal value proposition is affected by the penalty in efficiency which reduces the output power from VCSELs towards multimode VECSELs and finally single mode VECSELs. The root causes for this lower efficiency are optical losses in the extended cavity, a mismatch of pump and mode profile and losses related to the oxide aperture which is used for current confinement. The reduction of losses requires a careful design of spatial doping distributions in the epitaxially grown layers as these losses have to be balanced against the requirement of low electrical resistance across the many hetero-interfaces in the DBR mirrors. The mismatch of pump and mode profile and the aperture related losses are addressed by an improved current injection enabled by a tailored electrical contact. In this paper optimized structures will be presented which enable a significant increase of efficiency and output power towards more than 150mW in a single mode and more than 300mW in multimode operation. The optical concept of the extended cavity can use a plane mirror in the simplest case thus facilitating the power scaling in arrays with many individual VECSEL apertures combined on a single chip.
A comparative study of the allomerization reaction of chlorophyll a and bacteriochlorophyll a (1998)

A combined spectroscopic and chromatographic approach has been employed to study the products of allomerization of chlorophyll a (chl a), bacteriochlorophyll a (bchl a) and bacterioviridin (bvir) under a variety of conditions. Using high-performance liquid chromatography, mass spectrometry (MS), tandem-MS, NMR spectroscopy, UV–VIS absorption spectroscopy and protected surface-enhanced resonance Raman spectroscopy we have identified the allomers formed under all the conditions. Analysis of the different product distributions enables us to reach conclusions about the reaction mechanism. Water is identified as the source of hydroxyl in the allomerization reaction and it is firmly established that a C(132)-CO2Me group is required for allomerization to occur. Under identical allomerization conditions, bchl a yields a distribution of products that is different from those given by chl a and bvir. This observation has allowed us to demonstrate that it is the bonding at the C(7)–C(8) position of chlorophylls and not the presence of a conjugated carbonyl functionality that influences the reactivity in ring E.
Enabling dynamic binary translation in embedded systems with scratchpad memory (2012)

Important challenges for embedded systems can be addressed by dynamic binary translation. A dynamic binary translator stores translated instructions in a software-managed code cache, which is usually large to minimize overhead. This article shows how to use a small scratchpad memory for the code cache. A small code cache may require frequent code evictions and retranslation, which degrade performance. We propose techniques to reduce the number of instructions inserted by the translator and a way to form fragments that minimizes translated code size. With our techniques, a much smaller code cache can hold a program's translated code working set.
Contents (2019)

This book illuminates the personal experience of being at the centre of a media scandal. The existential level of that experience is highlighted by means of the application of ethnological and phenomenological perspectives to extensive empirical material drawn from a Swedish context. The questions raised and answered in this book include the following: How does the experience of being the protagonist in a media scandal affect a person's everyday life? What happens to routines, trust, and self-confidence? How does it change the basic settings of his or her lifeworld?The analysis also contributes new perspectives on the fusion between interpersonal communication that takes place face to face, such as gossip and rumours, and traditional news media in the course of a scandal. A scandal derives its momentum from the audiences, whose engagement in the moral story determines its dissemination and duration. The nature of that engagement also affects the protagonist in specific ways. Members of the public participate through traditional oral communication, one vital aspect of which is activity in digital, social forums. The author argues that gossip and rumour must be included in the idea of the media system if we are to be able to understand the formation and power of a media scandal, a contention which entails critiques of earlier research. Oral interpersonal communication does not disappear when new communication possibilities arise. Indeed, it may be invigorated by them. The term news legend is introduced, to capture the entanglement between traditional news-media storytelling and oral narrative.
Bis(carbomethoxy)maleic anhydride (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBis(carbomethoxy)maleic anhydrideH. K. Hall Jr., R. C. Sentman, and P. NoguesCite this: J. Org. Chem. 1982, 47, 19, 3647–3649Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/jo00140a010https://doi.org/10.1021/jo00140a010research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts