gebhart/patrepeval huggingface dataset:
Atmospheric pressure air microplasma current time series for true random bit generation (2020)

Generating true random bits of high quality at high data rates is usually viewed as a challenging task. To do so, physical sources of entropy with wide bandwidth are required which are able to provide truly random bits and not pseudorandom bits, as it is the case with deterministic algorithms and chaotic systems. In this work we demonstrate a reliable high-speed true random bit generator (TRBG) device based on the unpredictable electrical current time series of atmospheric pressure air microplasma (APAMP). After binarization of the sampled current time series, no further post-processing was needed in order for the bitstreams to pass all 15 tests of the NIST SP 800-22 statistical test suite. Several configurations of the system have been successfully tested at different sampling rates up to 100 MS/s, and with different inter-electrode distances giving visible/non-visible optical emissions. The cost-effectiveness, simplicity and ease of implementation of the proposed APAMP system compared to others makes it a very promising solution for portable TRBGs.
Anaplastic Thyroid Cancers Harbor Novel Oncogenic Mutations of the <i>ALK</i> Gene (2011)

Thyroid cancer is the most common endocrine cancer, and targeted approaches to treat it pose considerable interest. In this study, we report the discovery of ALK gene mutations in thyroid cancer that may rationalize clinical evaluation of anaplastic lymphoma kinase (ALK) inhibitors in this setting. In undifferentiated anaplastic thyroid cancer (ATC), we identified two novel point mutations, C3592T and G3602A, in exon 23 of the ALK gene, with a prevalence of 11.11%, but found no mutations in the matched normal tissues or in well-differentiated thyroid cancers. These two mutations, resulting in L1198F and G1201E amino acid changes, respectively, both reside within the ALK tyrosine kinase domain where they dramatically increased tyrosine kinase activities. Similarly, these mutations heightened the ability of ALK to activate the phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein (MAP) kinase pathways in established mouse cells. Further investigations showed that these two ALK mutants strongly promoted cell focus formation, anchorage-independent growth, and cell invasion. Similar oncogenic properties were observed in the neuroblastoma-associated ALK mutants K1062M and F1174L but not in wild-type ALK. Overall, our results reveal two novel gain-of-function mutations of ALK in certain ATCs, and they suggest efforts to clinically evaluate the use of ALK kinase inhibitors to treat patients who harbor ATCs with these mutations.
Control of large scale wind power plants (2012)

Growing percentages of wind power penetration translate to more demanding requirements from grid codes; generally speaking, the replacement of traditional generation by large wind power plants requires more control capabilities as we are used in the past. Thus, wind energy technology has to be adapted to fulfill such requirements. Basically, when moving from small “wind parks” to wind power plants it is important to think in terms of plant control, and not anymore in terms of wind turbines individually producing energy without control coordination (or very poor). New wind power plants' turbine technologies can and should deliver control with features and performance that are equivalent or improved compared to other bulk power plant technologies, however, at this stage not only the wind turbine technology is important but also the plant control. With a large number of distributed controllable sources of active and reactive power, plant level control involves advanced dispatching and fast communication, two areas that have recently progressed in the application of wind power plant control. This paper presents a summary and analysis of wind power plant control topologies, pointing out the system challenges in regards to control and integration.
A method for locating nearby sources (2005)

A fast method for locating nearby sources based solely on the time-of-flight information is described. The time delays for a signal passing between all sensor pairs is determined using cross-correlations and a vector of time delays is constructed. In the noise free case, where the speed of sound is constant, each point in the plane is associated with a unique value of the time delay vector. The method we present uses a fast, simplex-based search of the plane for a source location by minimizing the difference between the vector associated with the candidate location on the plane and the value estimated from cross-correlations. The search takes place over the three dimensional space that includes two coordinates in the plane and the propagation speed. The starting point for the search is constructed from an analytic fit of circular wave fronts to groups of sensors within the array. This method has been useful in identifying near-field sources in the 153US and 155US CTBT/IMS infrasound arrays. Examples of the locations we have determined along with a description of the statistical confidence limits associated with the method will be presented.
A potential mechanism for selective control of cap-independent translation by a viral RNA sequence in cis and in trans (1999)

Highly efficient cap-independent translation initiation at the 5'-proximal AUG is facilitated by the 3' translation enhancer sequence (3'TE) located near the 3' end of barley yellow dwarf virus (BYDV) genomic RNA. The role of the 3'TE in regulating viral translation was examined. The 3'TE is required for translation and thus replication of the genomic RNA that lacks a 5' cap (Allen et al., 1999, Virology253:139-144). Here we show that the 3'TE also mediates translation of uncapped viral subgenomic mRNAs (sgRNA1 and sgRNA2). A 109-nt viral sequence is sufficient for 3'TE activity in vitro, but additional viral sequence is necessary for cap-independent translation in vivo. The 5' extremity of the sequence required in the 3' untranslated region (UTR) for cap-independent translation in vivo coincides with the 5' end of sgRNA2. Thus, sgRNA2 has the 3'TE in its 5' UTR. Competition studies using physiological ratios of viral RNAs showed that, in trans, the 109-nt 3'TE alone, or in the context of 869-nt sgRNA2, inhibited translation of genomic RNA much more than it inhibited translation of sgRNA1. The divergent 5' UTRs of genomic RNA and sgRNA1 contribute to this differential susceptibility to inhibition. We propose that sgRNA2 serves as a novel regulatory RNA to carry out the switch from early to late gene expression. Thus, this new mechanism for temporal control of translation control involves a sequence that stimulates translation in cis and acts in trans to selectively inhibit translation of viral mRNA.
RESEARCH AND DEVELOPMENT OF ENERGETIC IONIC LIQUIDS (2012)

urrent research programs are aiming to develop ionic liquids (ILs) as energetic materials for various applications. Such applications for ILs include both propulsion and explosives. Within the propulsion arena, a focus is to replace hydrazine (a highly toxic compound) as a fuel. The approach to replacing hydrazine is the synthesis and development of ILs with substantially less vapor toxicity and superior energy density. Hypergolic bipropellants are defined as fuel and oxidizer combinations that, upon contact, chemically react and release enough heat to spontaneously ignite, eliminating the need for an additional ignition source. The feasibility that an IL can undergo hypergolic ignition with a common oxidizer like nitric acid was demonstrated for the first time in our laboratory a few years ago (see references 1 and 2, below). Hazardous characteristics, undesirable physical and chemical properties of such ILs must be identified before further development by a potential user. IL-based fuels and their properties will be discussed (including limited safety and sensitivity, and thermophysical properties).
Integration of a Quantitative Feedback Theory (QFT)-Based Active Noise Canceller and 3D Audio Processor to Headsets (2007)

This paper seeks to enhance the quality of spatial sound reproduction by integrating two advanced signal processing technologies, active noise control (ANC) and three-dimensional (3D) audio, to a headset. The ANC module of the headset is designed based on the quantitative feedback theory (QFT), which is a unified theory that emphasizes the use of feedback for achieving the desired system performance tolerances in the face of plant uncertainties and plant disturbances. Performance, stability, and robustness of the closed-loop system have been taken into account in the loop-shaping procedure within a general framework of the QFT. On the other hand, 3D audio processing algorithms including the head-related-transfer-function and the reverberator are realized on the platform of a fixed-point digital signal processor. Listening tests were conducted to evaluate the proposed system in terms of various subjective performance indices. The experimental results revealed that the 3D headset is capable of delivering superior rendering quality of localization and spaciousness, with the aid of the ANC module.
In-place reconstruction of delta compressed files (1998)

Article Free Access Share on In-place reconstruction of delta compressed files Authors: Randal C. Burns IBM Almaden Research Center, 650 Harry Rd., San Jose, CA IBM Almaden Research Center, 650 Harry Rd., San Jose, CAView Profile , Darrell D. E. Long Department of Computer Science, University of California, Santa Cruz, CA Department of Computer Science, University of California, Santa Cruz, CAView Profile Authors Info & Claims PODC '98: Proceedings of the seventeenth annual ACM symposium on Principles of distributed computingJune 1998 Pages 267–275https://doi.org/10.1145/277697.277747Published:01 June 1998Publication History 12citation426DownloadsMetricsTotal Citations12Total Downloads426Last 12 Months15Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Anti-Metastatic Properties of a Marine Bacterial Exopolysaccharide-Based Derivative Designed to Mimic Glycosaminoglycans (2016)

Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high potency to form lung metastases. In this study, the effect of three oversulfated low molecular weight marine bacterial exopolysaccharides (OS-EPS) with different molecular weights (4, 8 and 15 kDa) were first evaluated in vitro on human and murine osteosarcoma cell lines. Different biological activities were studied: cell proliferation, cell adhesion and migration, matrix metalloproteinase expression. This in vitro study showed that only the OS-EPS 15 kDa derivative could inhibit the invasiveness of osteosarcoma cells with an inhibition rate close to 90%. Moreover, this derivative was potent to inhibit both migration and invasiveness of osteosarcoma cell lines; had no significant effect on their cell cycle; and increased slightly the expression of MMP-9, and more highly the expression of its physiological specific tissue inhibitor TIMP-1. Then, the in vivo experiments showed that the OS-EPS 15 kDa derivative had no effect on the primary osteosarcoma tumor induced by osteosarcoma cell lines but was very efficient to inhibit the establishment of lung metastases in vivo. These results can help to better understand the mechanisms of GAGs and GAG-like derivatives in the biology of the tumor cells and their interactions with the bone environment to develop new therapeutic strategies.
An architecture for a wavelength-interchanging cross-connect utilizing parametric wavelength converters (1999)

This paper proposes an architecture for a wavelength-interchanging cross-connect (WIXC) that can be used as a switching node of strictly transparent and scalable networks with all-optical routing and all-optical wavelength conversion capabilities. This architecture utilizes all-optical parametric wavelength converters based on difference-frequency-generation (DFG) or four-wave mixing (FWM), although this work focuses only on the implementation using difference-frequency-generation wavelength converters. The proposed WIXC architecture exploits the unique wavelength mapping properties of parametric wavelength converters: mirror image mapping and simultaneous multichannel wavelength conversion. The derivation of this architecture involves application of a space/wavelength transformation to the classical Benes switch fabric. The connection setup for the resulting architecture follows the well established looping algorithm, and the architecture is scalable in both the ports and the wavelengths. The scaling occurs in an orderly fashion, which allows modular upgrades of WIXC's for cost-effective evolution of the networks. The unique properties of the parametric wavelength converter including transparent and multichannel conversion capabilities result in a WIXC architecture that requires fewer wavelength converters while maintaining scalability and transparency.
Tailbiting MAP decoders (1998)

We extend the MAP decoding algorithm of Bahl et al. (1974) to the case of tail-biting trellis codes. An algorithm is given that is based on finding an eigenvector, and another that avoids this. Several examples are given. The algorithm has application to turbo decoding and source-controlled channel decoding.
CMOS active pixel sensor with on-chip successive approximation analog-to-digital converter (1997)

The first CMOS active pixel sensor (APS) with on-chip column-parallel successive-approximation analog-to-digital converter (ADC) is reported. A 64/spl times/64 element CMOS APS implemented in a 1.2-/spl mu/m n-well single-poly, double-metal process with 24-/spl mu/m pixel pitch is integrated with a 64/spl times/1 array of column parallel successive approximation 8-b ADCs. Good image quality was observed. The capacitively-coupled ADCs dissipate approximately 1 /spl mu/W-s/ksample and occupy 0.05 mm/sup 2/ of chip area.
Tensor Circuit Networks for Transformation Optics (2011)

In this presentation, we will describe transmission-line based metamaterials that can possess tensor constitutive parameters. The utility of tensor analysis in the design of such metamaterials will be shown. In addition, various microwave devices implemented using tensor transmission-line metamaterials will be demonstrated.
Radiation characteristics of circular waveguide antenna loaded with ferrite rod (2016)

High power waveguide antennas are widely used for military and commercial application. In this study, a magnetised ferrite rod loaded circular waveguide antenna (CWA) is presented, where the main beam is steered by varying the external magnetising field ( H 0 ). To predict the limitations of this multimode antenna, the modes supported by the structure and the lossy ferrimagnetic resonance region needs to be calculated. An analytical technique, based on boundary values, is used to derive six characteristic equations for the partially ferrite loaded CWA. The non‐trivial solution of the equations is used to plot the mode chart and identify the low‐loss operating region. Using HFSS simulator, the coaxially excited ferrite loaded CWA is optimised to demonstrate a beam scan up to ±30° for H 0 = ±142 KA/m. Experimental results are used to verify the simulated scan characteristics of the antenna.
Machine-learning techniques for fast and accurate holographic particle tracking (2018)

Quantitative analysis of holographic microscopy images yields the three-dimensional positions of micrometer-scale colloidal particles with nanometer precision, while simultaneously measuring the particles' sizes and refractive indexes. Extracting this information begins by detecting and localizing features of interest within individual holograms. Conventionally approached with heuristic algorithms, this image analysis problem can be solved faster and more generally with machine-learning techniques. We demonstrate that two popular machine-learning algorithms, cascade classifiers and deep convolutional neural networks (CNN), can solve the particle-tracking problem orders of magnitude faster than current state-of-the-art techniques. Our CNN implementation localizes holographic features precisely enough to bootstrap more detailed analyses based on the Lorenz-Mie theory of light scattering. The wavelet-based Haar cascade performs less well at detecting and localizing particles, but is so computationally efficient that it creates new opportunities for applications that emphasize speed and low cost. We demonstrate its use as a real-time targeting system for holographic optical trapping.
Differential effects of N-terminal modifications on the biological potencies of growth hormone releasing factor analogs with varying chain lengths (1987)

The excellent retention of biological potencies observed with human growth hormone releasing factor analogues with chains 29-44 amino acid residues long is suddenly lost when further amino acid residues are removed from the C-terminus. For instance, 1-27 and 1-24 exhibited little biological activity (greater than 1%) in vivo and in vitro in the rat. Studies were made to determine whether this was due to conformational changes rather than simply the loss of amino acids needed for direct receptor interactions. These involved the introduction of mild conformational restraint in the N-terminal region by the introduction of D-amino acid residues previously shown to increase the potency of the 1-29 peptide. D-Ala in position 2, responsible for a 40- to 50-fold increase in activity in the 1-29 species, resulted in little increase in the potency of 1-27 or 1-24 sequences. However, N-terminal acetylation, responsible for a 12-fold increase in 1-29 in vivo potency, caused greater than 50-fold increase in 1-27 potency but had little effect on 1-24 potency. Likewise, D-Asn in position 8 was far more effective in increasing the potency of the 1-27 sequence compared to the 1-29 ([D-Asn8]-GRF(1-29)NH2, 220% vs. [D-Asn8, Leu27]-GRF(1-27)NH2, 53%; in vivo]. This differential effect was even more clear in vitro. The highest in vivo potency in the 1-27 series was achieved with [D-Asp3,D-Asn8,Leu27]-GRF(1-27)NH2 (200%); however, this analogue was still far less potent than its 1-29 counterpart (3800%). None of the D-amino acid substitution strategies were effective in increasing 1-22 peptide potencies to detectable levels. The results indicate that the effect of N-terminal substitutions and resulting potencies of the GRFs is very much dependent on chain length, perhaps suggesting that C-terminal amino acids promote conformational effects at the N-terminus and/or vice versa.
Tailoring trehalose for biomedical and biotechnological applications (2017)

Trehalose is a non-reducing sugar whose ability to stabilize biomolecules has brought about its widespread use in biological preservation applications. Trehalose is also an essential metabolite in a number of pathogens, most significantly the global pathogen <i>Mycobacterium tuberculosis</i>, though it is absent in humans and other mammals. Recently, there has been a surge of interest in modifying the structure of trehalose to generate analogues that have applications in biomedical research and biotechnology. Non-degradable trehalose analogues could have a number of advantages as bioprotectants and food additives. Trehalose-based imaging probes and inhibitors are already useful as research tools and may have future value in the diagnosis and treatment of tuberculosis, among other uses. Underlying the advancements made in these areas are novel synthetic methods that facilitate access to and evaluation of trehalose analogues. In this review, we focus on both aspects of the development of this class of molecules. First, we consider the chemical and chemoenzymatic methods that have been used to prepare trehalose analogues and discuss their prospects for synthesis on commercially relevant scales. Second, we describe ongoing efforts to develop and deploy detectable trehalose analogues, trehalose-based inhibitors, and non-digestible trehalose analogues. The current and potential future uses of these compounds are discussed, with an emphasis on their roles in understanding and combatting mycobacterial infection.
Novel video transcoding system to efficiently realize combinations of use cases (2012)

In this paper, we propose a novel heterogeneous video transcoding system that is not only capable of performing the major operations expected of a transcoder, i.e. bit rate adaptation, spatial and temporal resolution scaling, format conversion between the most often used standards on the market, but also any combination of operations. In addition, we propose novel transcoding algorithms to reduce the number of candidate modes and motion estimation refinement operations, leading to improved quality as well as reduced computational complexity. The unified system is implemented using Intel IPP Code Sample. The results show that the proposed unified system can, depending on the use case, be more than 2 times faster than the cascade transcoder, with small video quality degradation.
Charge-and-discharge Control Method of the Electric Power Storage Equipment Using Capacitors (2013)

In this paper, it has proposed about the charge-and-discharge control system which raises the efficiency of the electric power storage equipment using a capacitor by decreasing the variation in inter-terminal voltage of the capacitors resulting from the variation in capacitance. That is, by a pair of capacitors, and some switches which switch them in series or in parallel, circuit brock is constituted, further, the circuit brock is connected to n stage series, and an electric power storage part is constituted. And in order to always maintain the output voltage of an electric power storage part to allowable-input-voltage within the limits of an electric power converter, connection of the capacitors in each circuit block is switched in series or in parallel. In that case, when a multiple connection part is required, by constituting multiple connection parts not only including a pair of capacitors which constitute each block but two capacitors which adjoin mutually, inter-terminal voltage of all the capacitors is equalized, and the charge-and-discharge efficiency of electric power storage equipment is raised.
Automated contouring error detection based on supervised geometric attribute distribution models for radiation therapy: A general strategy (2015)

The proposed strategy can reliably identify contouring errors based upon inter- and intrastructural constraints derived from clinically approved contours. It holds great potential for improving the radiation therapy workflow. ROC and box plot analyses allow for analytically tuning of the system parameters to satisfy clinical requirements. Future work will focus on the improvement of strategy reliability by utilizing more training sets and additional geometric attribute constraints.
The emerging model of subscription computing (2002)

Subscription computing is a package of computer and networking hardware, system and selected application software, and support services necessary to build and maintain a basic computing platform. The package commonly includes a suite of personal-productivity applications, add-ins, and utilities. Some providers include a wide range of business services through a portal. Subscription computing puts the pieces of a computing platform together as a service, rather than as a collection of separately purchased components.