gebhart/patrepeval huggingface dataset:
Identification of the Sex Pheromone of the Invasive Scale Acutaspis albopicta (Hemiptera: Diaspididae), Arriving in California on Shipments of Avocados From Mexico (2012)

As a result of relaxation of importation restrictions ordered by the Animal and Plant Health Inspection Service of the U.S. Department of Agriculture, shipments of fresh avocados from Mexico began entering California year-round in 2007, despite the fact that these shipments were heavily infested with a number of exotic and potentially invasive armored scale species that are not thought to be present in California. Here, we report the identification of the sex pheromone of one of these species, Acutaspis albopicta (Cockerell), from a quarantine colony of these insects initiated from specimens collected from commercial shipments of Mexican avocados. The compound was identified as [(1S,3S)-2,2-dimethyl-3-(prop-1-en-2-yl)cyclobutyl)]methyl (R)-2-methylbutanoate, and was similar in structure to the pheromones of several other scale and mealybug species. In laboratory bioassays, the pheromone was highly attractive to male scales in microgram doses. The pheromone will provide a very sensitive and selective tool for detection of the scale to try and prevent its permanent establishment in California.
Ancient diversification of eukaryotic MCM DNA replication proteins (2009)

A multifaceted and heterogeneous Mcm2-7 hexamer evolved during the early evolution of the eukaryote cell in parallel with numerous other acquisitions in cell complexity and prior to the diversification of extant eukaryotes. The conservation of all six paralogues throughout the eukaryotes suggests that each Mcm2-7 hexamer component has an exclusive functional role, either by a combination of unique lock and key interactions between MCM hexamer subunits and/or by a range of novel side interactions. Mcm8 and 9 evolved early in eukaryote cell evolution and their pattern of presence or absence suggests that they may have linked functions. Mcm8 is highly divergent in all Drosophila species and may not provide a good model for Mcm8 in other eukaryotes.
Synthesis and material properties of elastomeric high molecular weight polycycloacetals derived from diglycerol and <i>meso</i>‐erythritol (2019)

ABSTRACT Copolymerizing glutaraldehyde with tetraols such as diglycerol, meso ‐erythritol, and pentaerythritol is particularly effective for forming very high molecular weight polycycloacetals ( M n up to 65,000 g/mol) with elastomeric properties and up to 70% biorenewable content by weight. Altering the tetraol monomer feed ratio provides control over the polycycloacetal's tensile properties. The polymerizations are high‐yielding, readily scalable, and employ commercially available starting materials that are used without further purification. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48780.
Machine learning and image-based profiling in drug discovery (2018)

The increase in imaging throughput, new analytical frameworks and high-performance computational resources open new avenues for data-rich phenotypic profiling of small molecules in drug discovery. Image-based profiling assays assessing single-cell phenotypes have been used to explore mechanisms of action, target efficacy and toxicity of small molecules. Technological advances to generate large data sets together with new machine learning approaches for the analysis of high-dimensional profiling data create opportunities to improve many steps in drug discovery. In this review, we will discuss how recent studies applied machine learning approaches in functional profiling workflows with a focus on chemical genetics. While their utility in image-based screening and profiling is predictably evident, examples of novel insights beyond the status quo based on the applications of machine learning approaches are just beginning to emerge. To enable discoveries, future studies also need to develop methodologies that lower the entry barriers to high-throughput profiling experiments by streamlining image-based profiling assays and providing applications for advanced learning technologies such as easy to deploy deep neural networks.
Selected Criticism, 1915–1929 (2010)

October 01 2010 Selected Criticism, 1915–1929 Osip Brik Osip Brik Search for other works by this author on: This Site Google Scholar Author and Article Information Osip Brik Online Issn: 1536-013X Print Issn: 0162-2870 © 2010 October Magazine, Ltd. and Massachusetts Institute of Technology2010 October (2010) (134): 74–110. https://doi.org/10.1162/OCTO_a_00013 Cite Icon Cite Permissions Share Icon Share Twitter LinkedIn Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Osip Brik; Selected Criticism, 1915–1929. October 2010; (134): 74–110. doi: https://doi.org/10.1162/OCTO_a_00013 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsOctober Search Advanced Search This content is only available as a PDF. © 2010 October Magazine, Ltd. and Massachusetts Institute of Technology2010 Article PDF first page preview Close Modal You do not currently have access to this content.
Cloning, Expression, and Characterization of Mouse Tissue Factor Pathway Inhibitor (TFPI) (1998)

Tissue factor pathway inhibitor (TFPI) acts to regulate the initiation of coagulation by first inhibiting factor Xa. The complex of factor Xa/TFPI then inhibits the factor VIIa/tissue factor complex. The cDNA sequences of TFPI from several different species have been previously reported. A high level of similarity is present among TFPIs at the molecular level (DNA and protein sequences) as well as in biochemical function (inhibition of factor Xa, VIIa/tissue factor). In this report, we used a PCR-based screening method to clone cDNA for full length TFPI from a mouse macrophage cDNA library. Both cDNA and predicted protein sequences show significant homology to the other reported TFPI sequences, especially to that of rat. Mouse TFPI has a signal peptide of 28 amino acid residues followed by the mature protein (in which the signal peptide is removed) which has 278 amino acid residues. Mouse TFPI, like that of other species, consists of three tandem Kunitz type domains. Recombinant mouse TFPI was expressed in the human kidney cell line 293 and purified for functional assays. When using human clotting factors to investigate the inhibition spectrum of mouse TFPI, it was shown that, in addition to human factor Xa, mouse TFPI inhibits human factors VIIa, IXa, as well as factor XIa. Cloning and expression of the mouse TFPI gene will offer useful information and material for coagulation studies performed in a mouse model system.
Short-term output power forecasting of photovoltaic systems based on the deep belief net (2017)

Photovoltaic power is now a major green energy resource, and its generated power can be directly connected to the power grid. However, the stability of power grid may be affected by the random and intermittent characteristics of photovoltaic power. In order to solve this problem, a forecasting model based on the deep belief nets is proposed. First, affecting factors of photovoltaic power generation are studied, including solar radiation intensity, air temperature, relative humidity, and wind speed. Based on the correlation coefficient between output power and each factor, the most influential factors can be determined and used as inputs of the proposed forecasting model for training process. Second, the forecasting model is then established and applied to predict the photovoltaic output powers for 2 weeks in summer and winter, respectively. The mean absolute percentage error, mean squared error, and Theil’s inequality coefficient are used to evaluate the performance efficiency between the proposed deep belief net model and back propagation neural network model. The performance outcomes reveal that the proposed deep belief net model can improve the prediction errors with rapid convergence significantly, better than the back propagation model.
NaviCam:A Magnifying Glass Approach to Augmented Reality (1997)

Current augmented reality (AR) systems are not designed to be used in our daily lives. Head-mounted see-through displays are too cumbersome and look too unusual for everyday life. The limited scalability of position-tracking devices limits the use of AR to very restricted environments. This paper proposes a different way to realize AR that can be used in an open environment by introducing the concept of ID awareness and a hand-held video see-through display. Unlike other AR systems that use head-mounted or head-up displays, our approach employs the combination of a palmtop-sized display and a small video camera. A user sees the real world through the display device, with added computer-augmented information. We call this configuration the magnifying glass approach. It has several advantages over traditional head-up or head-mounted configurations. The main advantage is that the user is not required to wear any cumbersome headgear. The user can easily move the display device around like a magnifying glass and compare real and augmented images. The video camera also obtains information related to real-world situations. The system recognizes real-world objects using the video images by reading identification (ID) tags. Based on the recognized ID tag, the system retrieves and displays information about the real-world object to the user. The prototype hand-held device based on our proposed concept is called NaviCam. We describe several potential applications. Our experiments with NaviCam show the great potential of our video see-through palmtop display. It was significantly faster than a head-up configuration, and its subjective score from testers was also higher.
Management of stroke and transient ischemic attack. (2002)

Stroke is a major cause of death and disability. The resulting burden on society continues to grow, despite recent advances in acute stroke therapy. Thrombolysis reduces stroke morbidity but is only applicable to a small percentage of stroke patients. Acute stroke units, which allow for the greatest overall improvement in outcome, provide the best facilities for acute intervention. Despite recent advances in acute management, such as endarterectomy and anticoagulation, primary and secondary preventive measures to control stroke risk factors, along with appropriate specific interventions, are the key to reducing the overall burden of stroke.
3D Reconstruction of Human Motion from Video (2013)

This paper presents a novel framework for 3D full body re- construction of human motion from uncalibrated monocular video data. We rst detect and track feature sets from video sequences by employing MSER and SURF feature detection techniques together with prior infor- mation obtained from the motion capture database. By deriving suitable feature sets from both video and motion capture data, we are able to employ fast motion retrieval techniques to nd the best relevant prior poses. The resulting 3D motion sequences are reconstructed by an energy minimization process that takes multiple prior terms into account.
Role of pili in adherence of Pseudomonas aeruginosa to mammalian buccal epithelial cells (1980)

Adherence of Pseudomonas aeruginosa organisms to the upper respiratory epithelium of seriously ill patients in vitro is correlated with subsequent colonization of the respiratory tract by this opportunistic pathogen. The role of pili in the attachment to epithelial cells of P. aeruginosa was studied in an in vitro system employing human buccal epithelial cells and P. aeruginosa pretreated by various means. Pretreatment of the bacteria with proteases, heat, or Formalin caused a significant decrease in adherence. A decrease when compared with controls was also noted in the adherence of P. aeruginosa organisms to buccal epithelial cells preincubated with purified pili prepared from the strain used for adherence testing; however, pili prepared from a heterologous strain failed to block adherence. Similar results were obtained in serological studies when antisera to purified pili prepared from the strain used for adherence testing decreased adherence, whereas heterologous antiserum to pili did not decrease adherence. From these results it appears that pili mediate the adherence of P. aeruginosa organisms to human buccal epithelial cells.
Three-dimensional cut wire pair behavior and controllable bianisotropic response in vertically oriented meta-atoms (2017)

This paper investigates three-dimensional cut wire pair (CWP) behavior in vertically oriented meta-atoms. We first analyze CWP metamaterial inclusions using full-wave electromagnetic simulations. The scattering behavior of the vertical CWP differs substantially from that of the planar version of the same structure. In particular, we show that the vertical CWP supports a magnetic resonance that is solely excited by the incident magnetic field. This is in stark contrast to the bianisotropic resonant excitation of in-plane CWPs. We further show that this CWP behavior can occur in other vertical metamaterial resonators, such as back-to-back linear dipoles and back-to-back split ring resonators (SRRs), due to the strong coupling between the closely spaced metallic elements in the back-to-back configuration. In the case of SRRs, the vertical CWP mode (unexplored in previous literature) can be excited with a magnetic field that is parallel to both SRR loops, and exists in addition to the familiar fundamental resonances of the individual SRRs. In order to fully describe the scattering behavior from such dense arrays of three-dimensional structures, coupling effects between the close-packed inclusions must be included. The new flexibility afforded by using vertical resonators allows us to controllably create purely electric inclusions, purely magnetic inclusions, as well as bianisotropic inclusions, and vastly increases the degrees of freedom for the design of metafilms.
Synthesis and Biological Activity of the Prodrug of Class I Major Histocompatibility Peptide GILGFVFTL Activated by β-Glucuronidase (2002)

The first synthesis of a prodrug of HLA-A2.1 associated antigenic influenza peptide 2a was accomplished. Two methods for synthesis of prodrugs of antigenic peptides activated by beta-glucuronidase and comprising a self-immolative 3-nitrobenzyloxycarbonyl moiety were investigated. Reaction of beta-glucuronic acid glycoside of 4-hydroxy-3-nitrobenzyl alcohol (3) with N,N'-disuccinimidyl carbonate (DSC) followed by conjugation with AlaOMe, Gly, Thr, Phe-Leu, and Leu-Arg gave carbamates 4a-4f. Deacetylation of 4b and 4e with MeONa/MeOH gave beta-glucuronides 5b and 5e. Compound 5e was converted to beta-glucuronic acid conjugate 6e by the action of pig liver esterase (PLE). Compound 6e is a substrate for beta-glucuronidase. Method of a direct introduction of the prodrug residue into antigenic nonapeptide GILGFVFTL (2b) failed. Alternately, glycine conjugate 5b was activated to pentafluorophenyl ester 10. Model coupling of 10 with Phe-Leu gave tripeptide conjugate ester 11a which was hydrolyzed by PLE to uronic acid 12. Condensation of 10 with octapeptide ILGFVFTL (9) gave prodrug precursor 11b. Octapeptide 9 was prepared by de novo synthesis using a racemization-free fragment coupling method. Ester hydrolysis with Ba(OH)(2)/MeOH gave the target prodrug 2a which is a substrate for beta-glucuronidase. Prodrug 2a does not bind to HLA-A2.1 of T2 human cells defective in major histocompatibility complex I (MHC I)-associated peptide processing. Addition of beta-glucuronidase restored the binding to the level observed with parent nonapeptide 2b although higher concentrations of prodrug 2a and enzyme were necessary.
Search Space Mapping:  Getting a Picture of Coherent Laser Control (2006)

Search space mapping is a method for quickly visualizing the experimental parameters that can affect the outcome of a coherent control experiment. We demonstrate experimental search space mapping for the selective fragmentation and ionization of para-nitrotoluene and show how this method allows us to gather information about the dominant trends behind our achieved control.
Physiological changes in insulin resistance in human pregnancy: longitudinal study with the hyperinsulinaemic euglycaemic clamp technique (1998)

The timing and extent of changes in insulin resistance are of physiological importance because they affect all classes of maternal and fetal substrates.
G-proteins (2012)

Animals have evolved multiple strategies for coping with the presence of pathogenic microbes. The best characterized is the immune response where animals activate their physical and cellular defenses to respond to invading microorganisms. However, behavioral changes can also be triggered by exposure to microbes and play an important role in defending many species, including humans, from pathogen attack. In our recent study we demonstrate that, following infection, C. elegans uses the same G-protein signaling pathway in neurons and epithelial cells to coordinate avoidance behaviors and immune responses. Coordination of these responses allows animals to mount an immune response to the immediate threat while simultaneously taking action to remove the pathogen, however, the complicated nature of the mammalian brain and immune system has made it difficult to identify the molecular mechanisms mediating these interactions. With its simple, well described, nervous system and a rapidly growing understanding of its immune system, C. elegans has emerged as an excellent model to study the mechanisms by which animals recognize pathogens and coordinate behavioral and immune responses to infection.
Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers (2015)

Bone cancers are characterised by the development of tumour cells in bone sites, associated with a dysregulation of their environment. In the last two decades, numerous therapeutic strategies have been developed to target the cancer cells or tumour niche. As the crosstalk between these two entities is tightly controlled by the release of polypeptide mediators activating signalling pathways through several receptor tyrosine kinases (RTKs), RTK inhibitors have been designed. These inhibitors have shown exciting clinical impacts, such as imatinib mesylate, which has become a reference treatment for chronic myeloid leukaemia and gastrointestinal tumours. The present review gives an overview of the main molecular and functional characteristics of RTKs, and focuses on the clinical applications that are envisaged and already assessed for the treatment of bone sarcomas and bone metastases.
Solvent‐Induced Self‐Assembly of a <i>Meta</i>‐Linked Conjugated Polyelectrolyte. Helix Formation, Guest Intercalation, and Amplified Quenching (2004)

A water-soluble meta-linked poly(phenylene ethynylene) is shown to fold into a helical conformation in water. The helix is stabilized by solvophobic forces and π-stacking interactions. The metallo-intercalator complex Ru(dppz)(phen)22+ binds to the helical polymer via intercalation and the complex is highly luminescent when it is bound to the polymer (see Figure). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2004/c6711_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Caracterización epidemiológica, clínica, endoscópica e histológica del cáncer gástrico (2012)

Gastric cancer is a health problem worldwide. In order to characterize the disease, a descriptive prospective study was conducted at the Arnaldo Milian Castro and the Celestino Hernandez Robau University Hospitals during 2009. It measured socio-demographic, clinical, endoscopic and histological variables. The most common risk factors in patients with gastric cancer were the male sex (64.3%), an age between 51 and 60 years (35.7%), insufficient consumption of fruits and vegetables (81.0%), blood group A (45.2%) and chronic gastritis (26.2%). The main symptom was epigastric pain (64.3%) and the predominant signs were hematemesis and melena, both in 16.7% of cases. The main endoscopic findings were the ulcerated type of gastric cancer and a location at the level of the body (56.1% and 29.3% respectively). The diffuse-type adenocarcinoma was the predominant histologic type (56.4%), and the early diagnosis of gastric cancer is the key to a successful  treatment.
Encryption Characteristics of Two USB-based Personal Health Record Devices (2007)

Personal health records (PHRs) hold great promise for empowering patients and increasing the accuracy and completeness of health information. We reviewed two small USB-based PHR devices that allow a patient to easily store and transport their personal health information. Both devices offer password protection and encryption features. Analysis of the devices shows that they store their data in a Microsoft Access database. Due to a flaw in the encryption of this database, recovering the user's password can be accomplished with minimal effort. Our analysis also showed that, rather than encrypting health information with the password chosen by the user, the devices stored the user's password as a string in the database and then encrypted that database with a common password set by the manufacturer. This is another serious vulnerability. This article describes the weaknesses we discovered, outlines three critical flaws with the security model used by the devices, and recommends four guidelines for improving the security of similar devices.
Electrochromism of polyaniline film prepared by electrochemical polymerization (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochromism of polyaniline film prepared by electrochemical polymerizationAkira Watanabe, Kunio Mori, Yasunori Iwasaki, Yoshiro Nakamura, and Shigeya NiizumaCite this: Macromolecules 1987, 20, 8, 1793–1796Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/ma00174a015https://doi.org/10.1021/ma00174a015research-articleACS PublicationsRequest reuse permissionsArticle Views1889Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts