gebhart/patrepeval huggingface dataset:
La pintura como realidad: Manuel Huertas (1986)

Denosumab is a potent antiresorptive agent that substantially increases bone mineral density and reduces fracture rates at all skeletal sites for as long as it is administered. However, its favorable skeletal effects reverse quickly upon its discontinuation, because of a vast increase of osteoclast number and activity, which leads to a subsequent profound increase of bone turnover above pre-treatment values, a phenomenon commonly described as "rebound phenomenon". More importantly, most patients experience rapid, profound bone loss due to this burst of bone resorption that may lead in a minority of these patients to occurrence of fractures, especially multiple vertebral fractures. Therefore, subsequent antiresorptive treatment is mandatory, although the optimal regimen is yet to be clarified. In the present review, we outline what is currently known regarding the negative effects of denosumab discontinuation on different aspects of bone status, the factors that may affect them, and strategies to prevent them.
Comparison of quenching effects in single- and dual-flame photometric detectors (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of quenching effects in single- and dual-flame photometric detectorsPaul L. PattersonCite this: Anal. Chem. 1978, 50, 2, 345–348Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://pubs.acs.org/doi/10.1021/ac50024a043https://doi.org/10.1021/ac50024a043research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Translating controlled natural language query into SQL query using pattern matching technique (2014)

Database is a prime source of information. This information is accessed by a common man who is not able to write complex SQL query. Enabling common users to query databases using natural language and retrieve information from them has been a promising research area. A system is proposed to retrieve data from the database using Hindi language. Our system uses morphological analyzer and word group analyzer to extract the keyword from input Hindi query. Then it uses pattern matching technique to find the type of keyword. Also, it uses the controlled Hindi language interface and suggested query feature to reduce ambiguity and time for entering the Hindi query.
Interpretable Transformations with Encoder-Decoder Networks (2017)

Deep feature spaces have the capacity to encode complex transformations of their input data. However, understanding the relative feature-space relationship between two transformed encoded images is difficult. For instance, what is the relative feature space relationship between two rotated images? What is decoded when we interpolate in feature space? Ideally, we want to disentangle confounding factors, such as pose, appearance, and illumination, from object identity. Disentangling these is difficult because they interact in very nonlinear ways. We propose a simple method to construct a deep feature space, with explicitly disentangled representations of several known transformations. A person or algorithm can then manipulate the disentangled representation, for example, to re-render an image with explicit control over parameterized degrees of freedom. The feature space is constructed using a transforming encoder-decoder network with a custom feature transform layer, acting on the hidden representations. We demonstrate the advantages of explicit disentangling on a variety of datasets and transformations, and as an aid for traditional tasks, such as classification.
Treatments for fibrosis of the corpora cavernosa (2013)

This review covers conservative medical therapy for corporal fibrosis and surgical therapeutic methods. The roles of phosphodiesterase- 5 inhibitors and pentoxifylline are analysed. Surgical therapy includes implantation of a penile prosthesis and corporal reconstruction, and these are reviewed. Corporal fibrosis is a major problem for patients, and is associated with severe erectile dysfunction. Conservative treatment options can be applicable in the early phase, but simultaneous corporal reconstruction procedures with concomitant implantation of a penile prosthesis should be attempted in severe cases of corporal fibrosis.
Derivation of analytical expressions for the bit-error probability in lightwave systems with optical amplifiers (1990)

A description is given of a relatively simple derivation of the bit-error probability for a lightwave communications system using an amplitude-shift-keying (ASK) pulse modulation format and employing optical amplifiers such that amplified spontaneous emission noise dominates all other noise sources. Mathematically, this noise is represented as a Fourier series expansion with Fourier coefficients that are assumed to be independent Gaussian random variables. The bit-error probability is given in a closed analytical form that is derived by the approximate evaluation of several integrals appearing in the analysis. The author uses the theory to derive the Gaussian approximation and finds that it overestimates the bit-error rate by one to two orders of magnitude.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
PCR performance of a thermostable heterodimeric archaeal DNA polymerase (2014)

DNA polymerases are versatile tools used in numerous important molecular biological core technologies like the ubiquitous polymerase chain reaction (PCR), cDNA cloning, genome sequencing, and nucleic acid based diagnostics. Taking into account the multiple DNA amplification techniques in use, different DNA polymerases must be optimized for each type of application. One of the current tendencies is to reengineer or to discover new DNA polymerases with increased performance and broadened substrate spectra. At present, there is a great demand for such enzymes in applications, e.g., forensics or paleogenomics. Current major limitations hinge on the inability of conventional PCR enzymes, such as Taq, to amplify degraded or low amounts of template DNA. Besides, a wide range of PCR inhibitors can also impede reactions of nucleic acid amplification. Here we looked at the PCR performances of the proof-reading D-type DNA polymerase from P. abyssi, Pab-polD. Fragments, 3 kilobases in length, were specifically PCR-amplified in its optimized reaction buffer. Pab-polD showed not only a greater resistance to high denaturation temperatures than Taq during cycling, but also a superior tolerance to the presence of potential inhibitors. Proficient proof-reading Pab-polD enzyme could also extend a primer containing up to two mismatches at the 3' primer termini. Overall, we found valuable biochemical properties in Pab-polD compared to the conventional Taq, which makes the enzyme ideally suited for cutting-edge PCR-applications.
A comparative study of cardioprotective effect of three anesthetic agents by measuring serum level of troponin-T after coronary artery bypass grafting. (2012)

There were significant differences on cTnT levels between anesthetic groups of isofluran, midazolam and propofol at 36 hr after surgery. Preconditioning effect of isoflurane was higher than the other two groups.
Environmental toxicants and effects on female reproductive function. (2006)

One of the most toxic substances known to humans, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), is also highly pervasive in the environment. It is created naturally in volcanic eruptions and forest fires, and anthropogenically in waste incineration, chlorination processes and certain plastics manufacture. From reports of large industrial and other accidents, or from experimental studies, dioxin exposure has been correlated in animal models and/or humans with chloracne of the skin, organ cancers, hepatotoxicity, gonadal and immune changes, pulmonary and other diseases such as diabetes, skewing of the sex ratio, and infertility. We have demonstrated that the aromatic hydrocarbon receptor (AHR) that binds dioxin in tissues is localized in zebrafish, rat and rhesus monkey (Macaca mulatta) ovaries and in rat and human luteinizing granulosa cells (GC) (among other tissues), that labeled dioxin is specifically localized to granulosa cells of the ovarian follicle as observed by autoradiography, and that incubations of GC or ovarian fragments with environmentally relevant concentrations (fM to nM) of dioxin inhibit estradiol secretion significantly. Our experiments show that in human, non-human primate, rat, trout, and zebrafish ovarian tissues, dioxin inhibits estrogen synthesis at some level of the steroid biosynthetic pathway, most likely by inhibiting transcription of mRNAs for or activity of side-chain cleavage (Cyp11a1 gene) and/or aromatase (Cyp19a1 gene) enzymes, or conceivably other steroidogenic enzymes/factors. Such an untoward effect on estrogen synthesis in females exposed to dioxin environmentally may predispose them to defects in aspects of their fertility.
The investigation in a past of industry and engineering education to the new method proposal : 8 report The analysis of Japan college academic journal (2002)

Taking the result of bulletin "engineering education" and Japan Soc. of Mechanical Engineers magazine and proceedings of the Japan engineering education society as an element, the analysis was carried out to previous report. Some matters were clarified as the result. The result that it took up the academic journal in order to grasp the situation of technical college that engineering education and engineering education are widely carried out, and carried out the analysis is reported.
The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma (2018)

FGL2 facilitates glioma progression from low to high grade. Suppressing FGL2 expression holds therapeutic promise for halting malignant transformation in glioma.
Underactuated Adaptive Gripper Using Flexural Buckling (2013)

In gripping devices, adapting to highly unstructured environments such as irregularly shaped objects and surfaces continues to be challenging. To achieve safe and reliable gripping, many researchers have employed various underactuated mechanisms such as differential and compliant mechanisms. All these mechanisms have demonstrated successful gripping performances. They, however, have hardly considered scalability issues of underactuated mechanisms originating from additional force transmissions and onerous mechanism assembly. In this paper, we propose a structurally simple and scalable underactuated mechanism. The mechanism is demonstrated on a gripping device called the “Buckling gripper.” The Buckling gripper achieves adaptive gripping on rugged, uneven, and undulating surfaces typically found in the natural world. The key design principle of the Buckling gripper is inspired by a caterpillar's proleg that highly deforms depending on the shape of the contact surface. This key principle is applied to the gripper via flexural buckling. Normally, buckling is avoided in mechanical designs, but the buckling behavior of a flexure with an adequately selected length provides wide gripping range with a narrow range of force variation, which provides a sufficient number of contacts with even contact forces. As a result, the Buckling gripper achieves adaptive gripping on various surfaces, similar to a caterpillar.
The several combining “body” fault interpreting technique that is used in bayanchagan region (2013)

Fault is one of most common tectonic deformation style in a sedimentary basin,the relationship between the fault and Oil-gas reservoirs is research hot spot of Petroleum Geology all the time. Fault may control the formation and development of sedimentary basin, restrict the filling process of deposition, thus affect the geological factors and geological processes of oil and gas reservoirs. So before exploration and development to the study area, the study to the fault and the fracture system is the most basic work, and the fault interpretation is particularly important.The several combining "body" faults'interpreting technique (eigenvalue of coherency cub techniquevariance of coherency cub techniqueazimuth of coherency cub techniquedip testing technique) is used in this region. This test introduces the characteristics and the extracting methods of the several coherency , In the tectonic interpretation process of this region, we explicated complex faults and the fracture feature description more convenient.
Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms (2013)

Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore, important to understand the comprehensive interaction between the microbiological situation and the host immune responses that lead to prosthesis infections. Evidence indicates that prosthesis infections are actually biofilm-correlated infections that are highly resistant to antibiotic treatment and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future treatment options of prosthesis-related infections are discussed.
ChemInform Abstract: GROUP ANALYSIS OF VOLATILE AND NON‐VOLATILE N‐NITROSO COMPOUNDS (1974)

Abstract Es wird ein Verfahren zur gruppenspezifischen Bestimmung von flüchtigen und nicht= flüchtigen N‐Nitrosoverbindungen im ppb‐Bereich erläutert.
Development and Deployment of Orbital Drilling at Boeing (2006)

<div class="htmlview paragraph">Orbital hole drilling technology has shown a great deal of promise for cost savings on applications in the aerospace industry where burr free, high quality holes are a necessity. This presentation will show some of the basic research on orbital drilling development Boeing is doing with the Advanced Manufacturing Research Center at Sheffield University and the deployment of the technology into production programs within The Boeing Company.</div>
Glucocorticoid and retinoid regulation of alpha‐2 type I procollagen promoter activity (1992)

Glucocorticoids decrease type I procollagen synthesis by decreasing the steady state levels of procollagen mRNAs and mRNA synthesis. The present studies were undertaken to determine the functional sequences of the pro alpha 2(I) collagen gene required for the glucocorticoid-mediated decrease of type I procollagen mRNA synthesis. Embryonic mouse fibroblasts were stably transfected with the pR40 DNA CAT construct containing the 5' flanking region fragment from -2048 to +54 and the intronic fragment from +418 to +1524 of the mouse alpha 2(I) collagen gene. Dexamethasone treatment of these pR40 transfected fibroblasts resulted in a significant decrease in CAT activity which agrees with the glucocorticoid-mediated decrease of the steady state levels of type I procollagen mRNAs. To determine the possible role of the first intron fragment in the dexamethasone-mediated decrease of CAT activity, pR36, a CAT plasmid containing the first intron fragment and the SV40 early promoter, was transfected into mouse fibroblasts and treated with dexamethasone. No significant decrease in CAT activity was observed. The dexamethasone-mediated response was then localized within the 5' flanking region by preparing a series of constructs containing internal deletions and transfecting these plasmids into mouse fibroblasts. The regions -2048 to -981 and -506 to -351 were required for the dexamethasone response of gene activity. However, the DNA stretch from -981 to -506 was not. Analysis of the DNA sequences of these regions revealed a single GRE at -1023 to -1018 and a modified doublet at -873 to -856.(ABSTRACT TRUNCATED AT 250 WORDS)
Generation of miniaturized planar ecombinant antibody arrays using a microcantilever-based printer (2014)

Miniaturized (Ø 10 μm), multiplexed (>5-plex), and high-density (>100 000 spots cm(-2)) antibody arrays will play a key role in generating protein expression profiles in health and disease. However, producing such antibody arrays is challenging, and it is the type and range of available spotters which set the stage. This pilot study explored the use of a novel microspotting tool, Bioplume(TM)-consisting of an array of micromachined silicon cantilevers with integrated microfluidic channels-to produce miniaturized, multiplexed, and high-density planar recombinant antibody arrays for protein expression profiling which targets crude, directly labelled serum. The results demonstrated that 16-plex recombinant antibody arrays could be produced-based on miniaturized spot features (78.5 um(2), Ø 10 μm) at a 7-125-times increased spot density (250 000 spots cm(-2)), interfaced with a fluorescent-based read-out. This prototype platform was found to display adequate reproducibility (spot-to-spot) and an assay sensitivity in the pM range. The feasibility of the array platform for serum protein profiling was outlined.
Triangulating the Nation State through Translation. Some Reflections on "Nation", "Ethnicity", "Religion" and "Language" in Modern Japan, Germany and Nepal (2018)

This paper is an attempt at expanding and problematizing the Japan-German comparison of “nation state” in terms of religion, language, and ethnicity, by using Nepal as the third reference point. The main question raised concerns the translatability and effects of actual translation of four western concepts in the process of the spread of nationalism and the nation state: “nation state”, “religion”, “ethnicity” and “language”. First, it is demonstrated that they cannot be treated as neutral analytical concepts across languages, by investigating Japanese quasi-equivalents of these four categories, as well as looking at Johann Gottlieb Fichte’s Reden an die deutsche Nation with its various Japanese translations. In the second part, following a brief outline of the history of modern Nepal, it is shown how the Nepali state has treated, in legal terminology, what outside academics would call “ethnic”, “religious” and “linguistic” diversities, identifying various specificities which enrich the Japanese-German comparison.
Numerical Simulation of Fractured Carbonate Reservoirs with the M_1 Bimodal Pore System (2011)

Abstract Recent petrophysical analyses of Arab D limestone identify the M_1 bimodal pore system as the most common and important member of a new set of petrophysical rock types, which uses a new pore system classification based on extensive studies of a large and comprehensive collection of mercury injection capillary pressure (MICP) data set from Ghawar Arab D. The role played by the pore system parameters describing the macropores (M) and the micropores (Type 1) within the M_1 system indicates the significant contrast in flow parameters and wettability which may have strong implication on the microscopic displacement efficiency of carbonate reservoirs dominated by these multimodal pore systems. We propose to study this system as a system consisting of multiple interacting continua. Numerically, such a system is a generalization of the classical dual porosity dual permeability system into the multiple porosity multiple permeability framework. Since the micropores have permeability which can be four orders of magnitude smaller than the macropores, it is reasonable to neglect the inter-grid flow for the microspore. However, the micropores and macropores connectivity is at the rock fabric and is expected to be substantial. Additionally, the reservoirs are also known to include fractures and super-K regions. Thus, the parallel reservoir simulator is for a general system of multiple interacting continua. The parallel numerical methods will be discussed. We performed numerical studies to examine the sensitivity of a bimodal pore system in both fractured and non-fractured scenarios and contrast these against the traditional simulation of the single-mode pore system. Simulation results and discussions of the effect of flow parameters and wettability contrasts of the bimodal system in both the non-fractured and fractured area of the reservoir will be presented.
Adaptive Speech Dereverberation Using Constrained Sparse Multichannel Linear Prediction (2016)

In this letter, we present an adaptive speech dereverberation method based on constrained sparse multichannel linear prediction (MCLP), minimizing the mixed ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2,p</sub> norm of the desired component. In order to prevent overestimation of the undesired reverberant component, possibly leading to severe distortions of the output, we propose to use a statistical model for late reverberation to limit the power of the MCLP-based estimate. The resulting constrained optimization problem is solved by using the alternating direction method of multipliers, resulting in two variants of the dereverberation algorithm. Simulation results show that the proposed constraint increases the robustness with respect to parameter selection and improves the usability for dynamic scenarios in comparison to the unconstrained method.
Comparative trial of quinapril versus captopril in mild to moderate congestive heart failure (1994)

Objective To compare the efficacy and safety of captopril twice a day with quinapril once a day for the treatment of mild to moderate congestive heart failure in a multicentre, double-blind, randomly allocated, parallel-group, 12-week study. Methods Exercise capacity, M-mode echocardiographic left ventricular measurements and clinical signs and symptoms were evaluated. After a 2-week, single-blind, placebo washout period, the patients were randomly allocated to double-blind treatment with either captopril twice a day or quinapril once a day; the initial doses of 12.5 and 5 mg, respectively, were increased to 25 and 10mg, respectively, in the first month, and 50 and 20 mg in the second and third months, as required to achieve adequate blood pressure control. Baseline diuretic and/or digitalis therapy was allowed during the study, so that the patients were maintained in a stable condition. Results Data from 70 captopril- and 76 quinapril-treated patients were analysed. Both angiotensin converting enzyme inhibitors displayed comparable efficacy. Both drugs were well tolerated, with a low drop-out rate (11.4% for captopril and 10.5% for quinapril). Conclusion Treatment with 20 mg quinapril once a day was as effective and safe for the treatment of congestive heart failure as 100mg captopril administered twice a day.