gebhart/patrepeval huggingface dataset:
The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature (2006)

The HNO donor Angeli's salt elicits a potent and reproducible vasodilatation response. The results suggest that the response is elicited by HNO through sGC-mediated CGRP release and K(ATP) channel activation.
A Configurable Hardware Scheduler for Real-Time Systems. (2003)

The incidence of pertrochanteric fractures remained unchanged over the last 5 years. The relative incidence of pertrochanteric fractures is higher in elderly females; this may be explained by reduced bone mineral density and reduced trochanteric bone strength. Rigorous preventive treatments of osteoporosis should be considered in high-risk patients, along with improved safety measures to reduce falls.
Volterra differential equations with singular kernels (2017)

Motivated by the potential applications to the fractional Brownianmotion, we study Volterra stochasticdifferential of the form~:\begin{equation}X\_t = x+ \int\_0^tK(t,s)b(s,X\_s)ds + \int\_0^tK(t,s) σ(s,X\_s)\,dB\_s ,\tag{E} \label{eq:sdefbm}\end{equation}where $(B\_s, \, s\in [0,1])$ is a one-dimensional standard Brownianmotion and $(K(t,s), \, t,s \in [0,1])$ is a deterministic kernelwhose properties will be precised below but for which we don't assumeany boundedness property.
Tree tilt monitoring in rural and urban landscapes of Hong Kong using smart sensing technology (2020)

Urban trees are beneficial to our environment and important to human inhabitants. However, they are exposed to natural and anthropogenic stressors, such as strong windstorms, extreme wind events and accidents; inducing tree falling which can cause personal damages, economic losses and infrastructural destructions. The current study is the first of its kind, presenting a tree monitoring system, and using smart sensing devices installed on more than 8000 trees in Hong Kong's rural and urban landscapes. A description of the key components of the system, followed by big data analysis and three case studies of strong wind events over the past 2 years, are presented. A network of smart sensing devices was deployed to develop a large-scale, long-term, smart tree monitoring framework; to help identify potentially hazardous trees in urban areas, particularly during extreme weather events. The changes in tree tilt angle under natural wind loading were recorded. Patterns and responses of tree tilt angles were analyzed, with prediction using time series models based on the Seasonal Autoregressive Integrated Moving Average (SARIMA) and Extreme Gradient Boosting time series forecasting (xGBoost). The results showed the highest correlation for 1-hour forward forecasting, by applying xGBoost model on tree tilt data and weather observations (R2=0.90). On the other hand, SARIMA model produced one-step-ahead prediction with correlation (R2) ranging from 0.77 to 0.93, while lower correlation (R2 ≤ 0.55) was observed for long term prediction (15 days) of the tree tilt angles. Finally, a dashboard and mobile applications of tree monitoring systems were developed, to transfer knowledge and engage the public in understanding associated hazards with tree failures in the urban area.
Synaptic vesicular monoamine transporter expression: distribution and pharmacologic profile (1994)

The human vesicular monoamine transporter (hSVMT) cDNA predicts a protein of 515 amino acids that shares 92% amino acid identity with the rat cDNA. Northern analyses reveal expression of 4.3 kb SVMT mRNAs in rat hypothalamus, midbrain and brainstem, a 3 kb hSVMT mRNA in human brainstem and a 4.8 kb hSVMT mRNA in human hypothalamus. In situ hybridization documents significant SVMT expression in human nigra compacta neurons and in rat hypothalamic neurons whose distribution patterns are identical to those previously reported to display histaminergic markers. COS cell hSVMT expression yielded nanomolar affinities for tetrabenazine and reserpine, micromolar affinities for haloperidol, GBR12909, serotonin, mazindol, nomifensin and d-amphetamine, while dopamine, epinephrine, norepinephrine and histamine each displayed millimolar affinities. These observations extend the pharmacological characterization of hSVMT and studies of its distribution, and indicate likely physiological roles for SVMT in packaging monoamine transmitters including histamine.
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype (2011)

Cellular stress increases progressively with aging in mammalian tissues. Chronic stress triggers several signaling cascades that can induce a condition called cellular senescence. Recent studies have demonstrated that senescent cells express a senescence-associated secretory phenotype (SASP). Emerging evidence indicates that the number of cells expressing biomarkers of cellular senescence increases in tissues with aging, which implies that cellular senescence is an important player in organismal aging. In the brain, the aging process is associated with degenerative changes, e.g. synaptic loss and white matter atrophy, which lead to progressive cognitive impairment. There is substantial evidence for the presence of oxidative, proteotoxic and metabolic stresses in aging brain. A low-level, chronic inflammatory process is also present in brain during aging. Astrocytes demonstrate age-related changes that resemble those of the SASP: (i) increased level of intermediate glial fibrillary acidic protein and vimentin filaments, (ii) increased expression of several cytokines and (iii) increased accumulation of proteotoxic aggregates. In addition, in vitro stress evokes a typical senescent phenotype in cultured astrocytes and, moreover, isolated astrocytes from aged brain display the proinflammatory phenotype. All of these observations indicate that astrocytes are capable of triggering the SASP and the astrocytes in aging brain display typical characteristics of cellular senescence. Bearing in mind the many functions of astrocytes, it is evident that the age-related senescence of astrocytes enhances the decline in functional capacity of the brain. We will review the astroglial changes occurring during aging and emphasize that senescent astrocytes can have an important role in age-related neuroinflammation and neuronal degeneration.
Experiment research of contrast-enhanced ultrasonography in diagnosis of pancreatic laceration (2010)

Objective To approach the diagnostic value of contrast-enhanced ultrasonography(CEUS)for the detection of traumatic laceration of pancreas. Methods Sixty cases of pancreatic traumatic model were made in twelve healthy swines after the animals were anesthetized and laparotomized. Then the conventional ultrasonography(US) and CEUS were performed in each case to diagnose the traumatic region,immediately. The results were compared with surgical findings. Results Among sixty injuries,the detection rate of conventional ultrasonography was 66. 7%,the detection rate of CEUS was 88.3%. Conclusions CEUS shows higher detection rate than conventional US in diagnosing pancreatic laceration,and it also can improve the diagnostic value of ultrasound for the detection of pancreatic laceration.

Key words: 
Ultrasonography; Microbubbles; Pancreas; Rupture
Effects of the dual <scp>PPAR</scp> ‐α/γ agonist aleglitazar on glycaemic control and organ protection in the Zucker diabetic fatty rat (2012)

Aleglitazar strongly improved glycaemic and lipid parameters while protecting key tissues, including the pancreas, kidneys and eyes, against diabetes-associated structural and functional changes in the ZDF rat.
Multifunctional Reagents for Quantitative Proteome‐Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development (2015)

Novel multifunctional reagents were applied in combination with a lipid probe for affinity enrichment of myristoylated proteins and direct detection of lipid-modified tryptic peptides by mass spectrometry. This method enables high-confidence identification of the myristoylated proteome on an unprecedented scale in cell culture, and allowed the first quantitative analysis of dynamic changes in protein lipidation during vertebrate embryonic development.
Toward an RNaseA Mimic:  A DNAzyme with Imidazoles and Cationic Amines (2002)

Site-specific RNA cleavage has received considerable attention over the years. Directed synthesis to append imidazoles or amines or both to oligonucleotides to target specific RNA cleavage represents an exciting avenue of research. However, to date catalysis by such synthetic constructs, particularly in terms of turnover, has been difficult to observe. This is the first report of a truly catalytic M2+-independent DNAzyme synthetically modified with imidazoles and cationic amines that would seem to mimic RNaseA. This work now demonstrates how synthetic organic chemistry, when merged with combinatorial selection, can result in a new class of DNAzymes that meets the ongoing synthetic challenges for developing relatively small biomimetic catalysts.
LUMINA, una Cohorte de Pacientes con Lupus en Minorías Étnicas de Estados Unidos. ¿Qué Hemos Aprendido? (2004)

El Lupus Eritematoso Sistémico se comporta como una enfermedad más severa (en cuanto a manifestaciones clínicas, actividad de la enfermedad, acumulación de daño y sobrevida se refiere) entre las poblaciones no Caucásicas. Algunas características biológicas, genéticas, y socioeconómicas que difieren en los diversos grupos étnicos, juegan un papel importante en el curso y desenlace de la enfermedad. Hace más de diez años, con el fin de estudiar la influencia de estas características en la evolución y desenlace de la enfermedad, se constituyó una cohorte multiétnica de pacientes con lupus, la cual incluía pacientes de los diversos grupos étnicos que habitan en los Estados Unidos (Hispanos, Africano Americanos y Caucásicos): LUMINA (Lupus in Minorities: Nature vs Nurture). El propósito de este artículo, es describir las características más sobresalientes de la cohorte y los hallazgos más importantes derivados del estudio de estos pacientes. También se comentan los planes a futuro, específicamente el estudio del ¿admixture¿ genético, con el fin de distinguir la estrecha relación existente entre etnicidad y pobre condición socioeconómica.
A Cell Surfaceome Map for Immunophenotyping and Sorting Pluripotent Stem Cells (2012)

Induction of a pluripotent state in somatic cells through nuclear reprogramming has ushered in a new era of regenerative medicine. Heterogeneity and varied differentiation potentials among induced pluripotent stem cell (iPSC) lines are, however, complicating factors that limit their usefulness for disease modeling, drug discovery, and patient therapies. Thus, there is an urgent need to develop nonmutagenic rapid throughput methods capable of distinguishing among putative iPSC lines of variable quality. To address this issue, we have applied a highly specific chemoproteomic targeting strategy for de novo discovery of cell surface N-glycoproteins to increase the knowledge-base of surface exposed proteins and accessible epitopes of pluripotent stem cells. We report the identification of 500 cell surface proteins on four embryonic stem cell and iPSCs lines and demonstrate the biological significance of this resource on mouse fibroblasts containing an oct4-GFP expression cassette that is active in reprogrammed cells. These results together with immunophenotyping, cell sorting, and functional analyses demonstrate that these newly identified surface marker panels are useful for isolating iPSCs from heterogeneous reprogrammed cultures and for isolating functionally distinct stem cell subpopulations.
Strong consistency of a modified maximum likelihood estimator for controlled Markov chains (1980)

A controlled Markov chain with finite state space has transition probabilities which depend on an unknown parameter α lying in a known finite set A. For each α , a stationary control law ϕ α is given. This paper develops a control scheme whereby at each stage t a parameter α t is chosen at random from among those parameters which nearly maximize the log likelihood function, and the control u t is chosen according to the control law ϕ αt . It is proved that this algorithm leads to identification of the true α under conditions weaker than any previously considered.
Rheological Behavior and Microstructure of Ceramic Particulate/Aluminum Alloy Composites (1990)

The rheological behavior and microstructure were investigated using a concentric cylinder viscometer for three different slurries: semi-solid alloy slurries of a matrix alloy, Al-6.5wt percent Si: composite slurries, SiC (sub p) (8.5 microns)/Al-6.5wt percent Si, with the same matrix alloy in the molten state, and composite slurries of the same composition with the matrix alloy in the semi-solid state. The pseudoplasticity of these slurries was obtained by step changes of the shear rate from a given initial shear rate. To study the thixotropic behavior of the system, a slurry was allowed to rest for different periods of time, prior to shearing at a given initial shear rate. In the continuous cooling experiments, the viscosities of these slurries were dependent on the shear rate, cooling rate, volume fraction of the primary solid of the matrix alloy, and volume fraction of silicon carbide. In the isothermal experiments, all three kinds of slurries exhibited non-Newtonian behavior, depending on the volume fraction of solid particles.
Marginal zone B cells contribute to autoimmunity in the NZM2410 lupus prone mouse model. (159.13) (2012)

Abstract Lupus is an autoimmune disease in which the affected individual generates antibodies (Abs) against nuclear antigens such as DNA. Our NZM2410-derived triple congenic (TC) model of lupus expresses 3 previously characterized lupus susceptibility loci. We have previously shown that the breach of follicular exclusion of TC MZB cells is associated with disease progression. The production of nuclear autoAbs occurred in tandem with a large influx of TC MZB cells in the follicles. We also found an expansion of MZB cells in TC mice as compared to non-autoimmune B6 mice that occurs prior to the production of anti-DNA autoAbs, further suggesting that MZB cells may contribute to autoimmunity. MZB cell expansion is associated with the upregulation of Notch2 signaling in these cells. Adoptive transfer of TC or B6 splenic B cells into B6.Rag1-/- recipients indicated no difference in the homeostatic expansion of MZB cells from either donor strain, whether the recipients were treated or not with CpG. However, CpG-treated recipients of TC B cells produced more anti-ssDNA IgM than recipients of B6 B cells. Our transfer results showed that although TC MZB cells do not expand more than B6 MZB cells in a lymphopenic host, TC splenic B cells produce higher level of anti-ssDNA IgM in response to CpG stimulation. Further characterization of the TC MZB cells will determine more precisely how they contribute to autoimmunity.
LTBK-04. PHASE 2 MULTICENTER STUDY OF THE ONCOLYTIC ADENOVIRUS DNX-2401 (TASADENOTUREV) IN COMBINATION WITH PEMBROLIZUMAB FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192) (2020)

Abstract BACKGROUND A Phase 2 multi-center study was conducted to evaluate the replication-competent oncolytic adenovirus, DNX-2401 (tasadenoturev), in combination with the anti-PD-1 antibody, pembrolizumab, in subjects with recurrent glioblastoma. METHODS Subjects ≥ 18 years with glioblastoma at first or second recurrence were treated with a single intratumoral injection of 5e8-5e10 vp DNX-2401 at the time of biopsy, followed by 200 mg pembrolizumab infusions every 3 weeks until progression or toxicity. RESULTS Forty-nine subjects were enrolled at first (79.6%) or second (20.4%) recurrence after prior surgery (89.8%), radiotherapy (100%), and temozolomide (100%). Forty-eight of 49 (98%) were treated with 5e8 vp (n=3), 5e9 vp (n=3), or 5e10 vp (n=42) DNX-2401 and pembrolizumab. Median treatment duration was 7 cycles (range 1–35) with one subject remaining on treatment (cycle 31). Adverse events were primarily mild to moderate, consistent with underlying disease, and manageable. Headache, brain edema, and fatigue are the most common events reported as related to the treatment regimen. Of subjects treated with full dose DNX-2401 and pembrolizumab (n=42), 5 subjects (11.9%) had confirmed responses, including 2 durable ongoing complete responses and 3 partial responses. One subject remains tumor free &gt; 12 months after completing the planned 24 months of pembrolizumab. Median overall survival was 12.5 months; OS-12 and OS-18 were 54.5% and 20.8%, respectively. Four subjects, all of which have survived more than 21 months, continue to be followed for survival. CONCLUSIONS DNX-2401 plus pembrolizumab provides encouraging activity and is safe in patients with recurrent glioblastoma. A global, randomized, controlled Phase 3 study is planned.
Assessing prescriptive improvements to a system's cyber security and resilience (2016)

In the process of creating new capabilities, and improving the efficiency of existing operational processes, as a society, we have become dependent on information and communications technology (ICT). ICT is now integral to almost every aspect of our daily activities. The detrimental impact of these ICT dependencies, however, is that business operations become susceptible to possible impacts from cyber incidents. Protecting ICT from cyber incident effects or reducing their impacts on operational activities has become a problem of national importance. Concomitantly, there is an escalating imperative to identify and minimize operational cyber risk. In almost all circumstances, we are interested in achieving operational resilience: the ability for systems to continue to fulfil their intended purpose in the face of actual or potential cyber incidents. Achieving such resilience almost always must be pursued in a resource limited environment, where there is a need to justify the costs and resources needed. Unfortunately most current definitions of resilience are qualitative ones. If resilience is defined in a qualitative rather than quantitative way there is little in the way of prescriptive advice that can be offered to increase resilience. To address this deficiency we use a quantitative definition of resilience and apply it in a game theory inspired approach that considers multiple cyber attacker moves ahead. This allows us to assess defender actions as a portfolio analysis to identify a prescriptive selection of the best employment of security and resilience methods to use.
Hydrodynamic and Thermal Performance of Microchannels With Different In-Line Arrangements of Cylindrical Micropin Fins (2016)

This study presents results on the hydrodynamic and thermal characteristics of single-phase water flows inside microchannels (MCs) with different micropin fin (MPF) configurations. Different inline arrangements of micropin fins were considered over Reynolds numbers ranging from 20 to 160. The computational studies were performed using the commercial software ansys 14.5. The hydrodynamic performances of the configurations were compared using two parameters, namely, pressure drop and friction factor while the comparison in their thermal and thermal-hydraulic performances were based on Nusselt number and thermal performance index (TPI). Wake-pin fin interactions were carefully analyzed through streamline patterns in different arrangements and under different flow conditions. The results showed strong dependencies of all four evaluated performance parameters on the vertical pitch ratio (ST/D). Weaker dependencies on height over diameter ratio (H/D), horizontal pitch ratio (SL/D), and minimum available area (Amin) were observed. With an increase in the Reynolds number, extension of the wake regions behind MPFs was observed to be the paramount factor in increasing pressure drop and Nusselt number. Regarding TPI, two adverse trends were observed corresponding to different ST/D ratios, while the effect of SL/D ratio was unique. For friction factors, H/D and SL/D ratios of 1 and 1.5, respectively, led to minimum values, while different ST/D ratios are needed for each diameter size for the maximum performance. Moreover, a twofold increase in Reynolds number resulted in about 40% decrease in friction factor in each configuration.
Nanomaterials via Laser Ablation/Irradiation in Liquid: A Review (2012)

Abstract Laser ablation of solid targets in the liquid medium can be realized to fabricate nanostructures with various compositions (metals, alloys, oxides, carbides, hydroxides, etc.) and morphologies (nanoparticles, nanocubes, nanorods, nanocomposites, etc.). At the same time, the post laser irradiation of suspended nanomaterials can be applied to further modify their size, shape, and composition. Such fabrication and modification of nanomaterials in liquid based on laser irradiation has become a rapidly growing field. Compared to other, typically chemical, methods, laser ablation/irradiation in liquid (LAL) is a simple and “green” technique that normally operates in water or organic liquids under ambient conditions. Recently, the LAL has been elaborately developed to prepare a series of nanomaterials with special morphologies, microstructures and phases, and to achieve one‐step formation of various functionalized nanostructures in the pursuit of novel properties and applications in optics, display, detection, and biological fields. The formation mechanisms and synthetic strategies based on LAL are systematically analyzed and the reported nanostructures derived from the unique characteristics of LAL are highlighted along with a review of their applications and future challenges.
Deformable Part Models are Convolutional Neural Networks (2014)

Deformable part models (DPMs) and convolutional neural networks (CNNs) are two widely used tools for visual recognition. They are typically viewed as distinct approaches: DPMs are graphical models (Markov random fields), while CNNs are "black-box" non-linear classifiers. In this paper, we show that a DPM can be formulated as a CNN, thus providing a novel synthesis of the two ideas. Our construction involves unrolling the DPM inference algorithm and mapping each step to an equivalent (and at times novel) CNN layer. From this perspective, it becomes natural to replace the standard image features used in DPM with a learned feature extractor. We call the resulting model DeepPyramid DPM and experimentally validate it on PASCAL VOC. DeepPyramid DPM significantly outperforms DPMs based on histograms of oriented gradients features (HOG) and slightly outperforms a comparable version of the recently introduced R-CNN detection system, while running an order of magnitude faster.
Ultra-wide band electromagnetic radiation does not affect UV-induced recombination and mutagenesis in yeast (1998)

Cell samples of the yeast Saccharomyces cerevisiae were exposed to 100 J/m2 of 254 nm ultraviolet (UV) radiation followed by a 30 min treatment with ultra-wide band (UWB) electromagnetic pulses. The UWB pulses (101-104 kV/m, 1.0 ns width, 165 ps rise time) were applied at the repetition rates of 0 Hz (sham), 16 Hz, or 600 Hz. The effect of exposures was evaluated from the colony-forming ability of the cells on complete and selective media and the number of aberrant colonies. The experiments established no effect of UWB exposure on the UV-induced reciprocal and non-reciprocal recombination, mutagenesis, or cell survival.