gebhart/patrepeval huggingface dataset:
SAW-based hybrid transceivers in slam packaging with frequency range from 200 to 1000 MHz (2002)

Short range unlicensed RF links have become extremely popular all around the world. Some examples of these links include automotive keyless entry, wireless security systems, computer data links, ID cards and remote meter reading. The new transceiver described in this paper is ideally suited for these applications. It takes advantage of a new architecture that uses a single ASIC and two SAW devices. The entire transceiver is enclosed in a surface mount package with dimensions of 10.2 by 7.06 by 2.03 mm. The device is capable of either OOK or ASK modulation with data rates exceeding 100 kb/s. The sensitivity of the receiver at 1.2 kb/s is -105 dBm. The receiver architecture takes advantage of amplifier sequencing, which allows a stable RF gain of 85 dB at the incoming RF signal frequency of interest. The sequencing of the amplifiers effectively gates crosstalk out of the SAW filters allowing out-of-band rejection levels approaching 100 dB. The transmitter uses the same two SAW devices employed in the receiver for frequency stabilization and harmonic filtering.
A low cross-polarization decade-bandwidth Vivaldi array (2015)

A single-polarized, decade-bandwidth Vivaldi array with low cross-polarization is proposed. The array, termed the Sliced Notch Antenna (SNA) Array, exhibits the wideband impedance performance of Vivaldi arrays, yet it readily over-comes polarization purity degradation while scanned in the non-principal planes. The critical enabling technical innovation is the control of vertical surface current radiation through innovative discontinuities along the flared fins that are designed for decade-bandwidth impedance performance. The concept and performance are demonstrated through infinite array HFSS simulations and finite array Domain Decomposition Finite Element Method (DD-FEM) numerical results of a 19×19 SNA/Vivaldi array PCB-based prototypes.
Generation of a Transplantable Population of Human iPSC-Derived Retinal Ganglion Cells (2020)

Optic neuropathies are a major cause of visual impairment due to retinal ganglion cell (RGC) degeneration. Human induced-pluripotent stem cells (iPSCs) represent a powerful tool for studying both human RGC development and RGC-related pathological mechanisms. Because RGC loss can be massive before the diagnosis of visual impairment, cell replacement is one of the most encouraging strategies. The present work describes the generation of functional RGCs from iPSCs based on innovative 3D/2D stepwise differentiation protocol. We demonstrate that targeting the cell surface marker THY1 is an effective strategy to select transplantable RGCs. By generating a fluorescent GFP reporter iPSC line to follow transplanted cells, we provide evidence that THY1-positive RGCs injected into the vitreous of mice with optic neuropathy can survive up to 1 month, intermingled with the host RGC layer. These data support the usefulness of iPSC-derived RGC exploration as a potential future therapeutic strategy for optic nerve regeneration.
Photoluminescence spectra of oxygen-doped ZnSe grown by molecular-beam epitaxy (1989)

The optical properties of oxygen-doped ZnSe grown by molecular-beam epitaxy were studied by means of photoluminescence spectroscopy. Oxygen-related peaks were observed at about 4437 and at about 4550 A\r{}, where phonon replicas also appeared. These peaks may be caused by the radiative recombination of excitons bound to neutral oxygen atoms and donor-to-oxygen-acceptor emission, respectively. Observation of donor-acceptor emission in which the acceptor is an isoelectronic acceptor is reported for the first time. Oxygen, which is an isoelectronic impurity in ZnSe, can act as an acceptor in the same way as the generally used dopants such as nitrogen. A model for the oxygen in ZnSe acting as an acceptor is proposed. The acceptor level and the effective charge of oxygen are estimated to be about 80 meV and -0.9, respectively, using the energy values of the luminescence peaks of bound-exciton and donor-acceptor emission.
An analog turbo decoder for the rate-1/3, 40 bit, UMTS turbo code (2005)

In this paper, we discuss the design and testing results of an analog 0.35 /spl mu/m CMOS turbo decoder for the rate-1/3, 40 bit UMTS turbo code. The prototype was successfully tested at nominal conditions (2 Mbit/s), with an overall power consumption of 10.3 mW at 3.3 V. The tested BER curve shows a limited performance loss (about 0.5 dB) with respect to that of the digital implementation. We also discuss a discrete-time model of the analog decoder which allows us to run BER simulations including circuit transient behavior and device mismatch in a very short time. Circuit-level simulations demonstrate the validity of our model. According to the discrete-time simulation, a significant contribution to the performance loss is due to device mismatch.
Phenotypic Distinction in <i>Enterococcus faecium</i> and <i>Enterococcus faecalis</i> Strains between Susceptibility and Resistance to Growth-Enhancing Antibiotics (1999)

Susceptibility of Enterococcus faecium and Enterococcus faecalis strains from animals and foods to growth-promoting antibiotics used in animal feed was tested by the agar dilution technique. Acquired resistance to bacitracin, narasin, tylosin, and virginiamycin was seen for both species, and for E. faecium, resistance to avilamycin and avoparcin was also seen. Drawing the distinction between susceptibility and resistance based on frequency distributions of MICs was easy with avoparcin, avilamycin, and tylosin but difficult with virginiamycin and to some extent also with bacitracin and narasin.
A unified Bayesian framework for face recognition (2002)

This paper introduces a Bayesian framework for face recognition which unifies popular methods such as the eigenfaces and Fisherfaces and can generate two novel probabilistic reasoning models (PRM) with enhanced performance. The Bayesian framework first applies principal component analysis (PCA) for dimensionality reduction with the resulting image representation enjoying noise reduction and enhanced generalization abilities for classification tasks. Following data compression, the Bayes classifier which yields the minimum error when the underlying probability density functions (PDF) are known, carries out the recognition in the reduced PCA subspace using the maximum a posteriori (MAP) rule, which is the optimal criterion for classification because it measures class separability. The PRM models are described within this unified Bayesian framework and shown to yield better performance against both the eigenfaces and Fisherfaces methods.
Microplate Chemiluminescent Assay for DNA Detection Using Apoperoxidase-Oligonucleotide as Capture Conjugate and HRP-Streptavidin Signaling System (2018)

A covalent conjugate of horseradish apoperoxidase and amino-containing oligonucleotide was synthesized for the first time. Using the obtained conjugate as a capture reagent chemiluminescent microtiter plate-based assay for detection of 35-mer fragment of hepatitis B virus (HBV) DNA (proof-of-concept analyte) was developed. To detect the target DNA, a signaling system consisted of biotinylated reporter oligonucleotide and HRP-streptavidin conjugate was used. The high sensitivity of the assay was due to the enhanced chemiluminescence reaction, where 3-(10′-phenothiazinyl)propane-1-sulfonate/N-morpholinopyridine pair was used as an enhancer. Under the optimized conditions the limit of detection and a working range of the assay were 3 pM and 6–100 pM, respectively. The assay sensitivity was 1.6 × 105 RLU/pM of target. The coefficient of variation (CV) for determination of HBV DNA within the working range was lower than 6%.
Clinical and immunological effects of low‐dose IFN‐<i>α</i> treatment in patients with corticosteroid‐resistant asthma (2003)

Interferon-alpha treatment was associated with dramatic improvements in the condition of patients with corticosteroid-resistant asthma with and without Churg-Strauss syndrome. Potential mechanisms of action include the establishment of a correct Th1/Th2 balance and the induction of the anti-inflammatory IL-10 gene.
Arnica montana Stimulates Extracellular Matrix Gene Expression in a Macrophage Cell Line Differentiated to Wound-Healing Phenotype (2016)

Arnica montana (Arnica m.) is used for its purported anti-inflammatory and tissue healing actions after trauma, bruises, or tissue injuries, but its cellular and molecular mechanisms are largely unknown. This work tested Arnica m. effects on gene expression using an in vitro model of macrophages polarized towards a "wound-healing" phenotype. The monocyte-macrophage human THP-1 cell line was cultured and differentiated with phorbol-myristate acetate and Interleukin-4, then exposed for 24h to Arnica m. centesimal (c) dilutions 2c, 3c, 5c, 9c, 15c or Control. Total RNA was isolated and cDNA libraries were sequenced with a NextSeq500 sequencer. Genes with significantly positive (up-regulated) or negative (down-regulated) fold changes were defined as differentially expressed genes (DEGs). A total of 20 DEGs were identified in Arnica m. 2c treated cells. Of these, 7 genes were up-regulated and 13 were down-regulated. The most significantly up-regulated function concerned 4 genes with a conserved site of epidermal growth factor-like region (p<0.001) and three genes of proteinaceous extracellular matrix, including heparin sulphate proteoglycan 2 (HSPG2), fibrillin 2 (FBN2), and fibronectin (FN1) (p<0.01). Protein assay confirmed a statistically significant increase of fibronectin production (p<0.05). The down-regulated transcripts derived from mitochondrial genes coding for some components of electron transport chain. The same groups of genes were also regulated by increasing dilutions of Arnica m. (3c, 5c, 9c, 15c), although with a lower effect size. We further tested the healing potential of Arnica m. 2c in a scratch model of wound closure based on the motility of bone marrow-derived macrophages and found evidence of an accelerating effect on cell migration in this system. The results of this work, taken together, provide new insights into the action of Arnica m. in tissue healing and repair, and identify extracellular matrix regulation by macrophages as a therapeutic target.
Collaborative optimization of distribution grid operation (2012)

Electrical utilities strive for optimal grid operations while increasing efficiency and maintaining high reliability. With the advent of the Smart Grid, these objectives remain important worldwide. Recently many separate optimization applications for distribution grid operation have been deployed, including FDIR, IVVC, OFR, and DR. These applications may have been developed with sophisticated optimization algorithms and provide value in their own right. However each application is designed to serve specific tasks and does not consider other optimization programs' existence and mutual impacts, resulting in significantly reduced benefits or even conflicting control actions. This paper intends to address some of the problems that can arise from the lack of coordination among the distribution optimization programs. Three typical operation scenarios will be explored to demonstrate the potentially detrimental consequences due to lack of coordination. The observations and results from the operation scenarios studied with the standard IEEE 123 Bus circuit indicate that a well-designed coordinating mechanism is necessary for the various optimization programs to work together properly while achieving their corresponding objectives. This paper proposes a collaborative approach to solve the problem by considering the multiple-time-interval look-ahead capabilities, incorporating all the available controls, and coordinating the multiple system objectives in each of the optimization applications.
Transvenous Extraction of Pacemaker Leads in Infective Endocarditis With Vegetations ≥20 mm: Our Experience (2011)

Transvenous extraction of pacing leads with larger vegetations is a feasible technique. There was a tendency toward symptomatic pulmonary embolism in patients with vegetations larger than 20 mm; however, morbidity and mortality were not influenced. We agree with the consensus that this procedure is highly useful and that the selection of the removal techniques will depend not only on the size of vegetation but also on prior cardiopulmonary conditions, concomitant cardiac surgery, atrial septal defect with risk of paradoxical embolism, center experience, and the possibility of complete removal of the device.
Effect of macrophage stimulation on collagen biosynthesis in the healing wound. (1997)

Immunomodulators that enhance macrophage function have been shown to be beneficial in a number of wound-healing models in humans and in experimental animals. The exact mechanism of this improved healing is unclear. To assess the role of collagen biosynthesis, the immunomodulator glucan phosphate was utilized in two murine models of wound healing, i.e., colon anastomosis and full-thickness skin incision. Tensile strength was evaluated using computer-assisted constant velocity tensiometry. Collagen biosynthesis was determined by assaying hydroxyproline content of wound hydrolysates by N-(9-fluorenyl)methoxycarbonyl/o-phthalaldehyde high-performance liquid chromatography. Experimental animals were treated with (1-3)-beta-D-glucan phosphate (250 mg/kg) intravenously 24 hours prior to colon anastomosis or skin incision. A second dose of glucan phosphate was given immediately postoperatively. Control animals received dextrose and water (5% w/v) intravenously. Tensile strength and hydroxyproline content were measured on postoperative Day 3. In the skin wound model, glucan phosphate treatment increased (P < 0.05) tensile strength by 42 per cent (342.5 +/- 12.2 vs 241.8 +/- 4.8 g), and hydroxyproline content was increased by 23.5 per cent (242.0 +/- 14.4 vs 196.8 +/- 10.5 pmol/microg; P < 0.05). In the glucan phosphate group, colon tensile strength was significantly (P < 0.05) increased by 34 per cent (34.2 +/- 2.3 g vs 45.8 +/- 2.1 g), and hydroxyproline content was increased by 7 per cent (47.45 +/- 3.31 vs 44.34 +/- 3.74 pmol/microg). These data indicate that macrophage modulation with glucan phosphate will increase tensile strength in experimental colon and skin wounds. In addition, we observed a positive correlation between glucan phosphate treatment, wound tensile strength, and collagen biosynthesis.
Fabrication and Characterization of Microlasers by the Sol-Gel Method (2005)

The present study explores the application of new materials systems for low threshold microlasers, and characterization of the microcavities. The sol-gel method is used for gain functionalization of high-Q microcavities. A detailed procedure for preparation of the sol-gel films by the spin-on or dip-coating method is presented. The effect of different process conditions on the properties and microstructure of the thin films is investigated through Fourier Transform Infrared (FTIR) Spectroscopy, Scanning Electron Microscopy (SEM), and etching rate test.

Surface gain functionalization of microsphere cavities is fabricated by coating the microsphere with a thin layer of Er3+-doped sol-gel films. The optical gain is due to the population inversion of rare earth ions in the sol-gel films. A fiber taper is used to both couple the pump power into and extract the laser power out of the microsphere laser. The laser dynamics change between continuous-wave and pulsating operation by varying the doping concentration and the thickness of the sol-gel films outside the microsphere.

Surface functionalization is also achieved on the microtoroid on a single silicon chip, which can be fabricated in parallel using wafer-scale processing and has characteristics that are more easily controlled than microsphere. The microtoroid can be selectively coated only at the periphery by making use of the variation of etching rate (in buffered HF) of sol-gel films with different degrees of densification. The laser performance of the gain functionalized microtoroids is investigated. Highly confined whispering gallery modes make possible single-mode microlasers. This work also shows that the high Q microtoroid laser has a linewidth much lower than 300 kHz.

The thesis explores fabrication of high Q microcavities directly from the sol-gel silica films deposited on a single silicon wafer. Quality factor as high as 2.5 x 10^7 at 1561 nm is obtained in toroidal microcavities formed of silica sol-gel, which allows Raman lasing at absorbed pump power below 1 mW. Additionally, Er3+-doped microlasers are fabricated from Er3+-doped sol-gel layers with control of the laser dynamics possible by varying the erbium concentration of the starting sol-gel material. Continuous lasing with a record threshold of 660 nW for erbium-doped microlaser on a silicon wafer is also obtained.

Analytic formulas are derived to predict the laser performance, such as the laser output power, the threshold power, and the differential quantum efficiency, under different loading condition, i.e. the air gap between the fiber-taper coupler and the cavities. The effect of Er3+ concentration on the minimum threshold is also investigated. In addition, we present a theoretical model in which we include paired ions as the saturable absorber. It shows that self-pulsing operation can be expected with paired-ions-induced quenching in the system. The pulsation frequency increases linearly with the square root of the pumping level, which is consistent with the experimental observation.
Optimal Rate Allocation for Energy-Efficient Multipath Routing in Wireless Ad Hoc Networks (2004)

In this paper, we address the problem of energy efficiency in wireless ad hoc networks. We consider an ad hoc network comprising a set of sources, communicating with their destinations using multiple routes. Each source is associated with a utility function which increases with the total traffic flowing over the available source-destination routes. The network lifetime is defined as the time until the first node in the network runs out of energy. We formulate the problem as one of maximizing the sum of the source utilities subject to a required constraint on the network lifetime. We present a primal formulation of the problem, which uses penalty functions to take into account the system constraints, and we introduce a new methodology for solving the problem. The proposed approach leads to a flow control algorithm, which provides the optimal source rates and can be easily implemented in a distributed manner. When compared with the minimum transmission energy routing scheme, the proposed algorithm gives significantly higher source rates for the same network lifetime guarantee.
Defining the transcriptional signature of skeletal muscle stem cells1,2 (2007)

Satellite cells, the main source of myoblasts in postnatal muscle, are located beneath the myofiber basal lamina. The myogenic potential of satellite cells was initially documented based on their capacity to produce progeny that fused into myotubes. More recently, molecular markers of resident satellite cells were identified, further contributing to defining these cells as myogenic stem cells that produce differentiating progeny and self-renew. Herein, we discuss aspects of the satellite cell transcriptional milieu that have been intensively investigated in our research. We elaborate on the expression patterns of the paired box (Pax) transcription factors Pax3 and Pax7, and on the myogenic regulatory factors myogenic factor 5 (Myf5), myogenic determination factor 1 (MyoD), and myogenin. We also introduce original data on MyoD upregulation in newly activated satellite cells, which precedes the first round of cell proliferation. Such MyoD upregulation occurred even when parent myofibers with their associated satellite cells were exposed to pharmacological inhibitors of hepatocyte growth factor and fibroblast growth factor receptors, which are typically involved in promoting satellite cell proliferation. These observations support the hypothesis that most satellite cells in adult muscle are committed to rapidly entering myogenesis. We also detected expression of serum response factor in resident satellite cells prior to MyoD expression, which may facilitate the rapid upregulation of MyoD. Aspects of satellite cell self-renewal based on the reemergence of cells expressing Pax7, but not MyoD, in myogenic cultures are discussed further herein. We conclude by describing our recent studies using transgenic mice in which satellite cells are traced and isolated based on their expression of green fluorescence protein driven by regulatory elements of the nestin promoter (nestin-green fluorescence protein). This feature provides us with a novel means of studying satellite cell transcriptional signatures, heterogeneity among muscle groups, and the role of the myogenic niche in directing satellite cell self-renewal.
Principios generales de la rehabilitación neuropsicológica (2020)

Este artículo es la traducción del seminario del mismo nombre llevado a cabo el 23 de Enero de 2017 en la Facultad de Psicología de la Universidad Diego Portales (Santiago, Chile), como parte de las actividades de extensión del Diplomado en Rehabilitación Neuropsicológica del Adulto. Bárbara Wilson es Neuropsicóloga Clínica e investigadora en Rehabilitación Neuropsicológica en UK. Es la fundadora del centro de rehabilitación Oliver Zangwill (Ely, UK) y ha trabajado por más de 40 años en el desarrollo de la disciplina a nivel mundial. Bárbara es fundadora y editora de la revista Neuropsychological Rehabilitation. En esta presentación, Bárbara expone su visión respecto a los pilares de la Rehabilitación Neuropsicológica de adultos con lesión cerebral adquirida, la cual ha destilado de su productivo trabajo clínico e investigativo.
Investigations into the antibacterial behavior of copper nanoparticles against Escherichia coli (2010)

Zerovalent copper nanoparticles (Cu0) of 12 nm size were synthesized using an inert gas condensation method in which bulk copper metal was evaporated into an inert environment of argon with subsequent cooling for nucleation and growth of nanoparticles. Crystalline structure, morphology and estimation of size of nanoparticles were carried out by X-ray diffraction and transmission electron microscopy. The antibacterial activity of these nanoparticles against the Gram-negative bacterium Escherichia coli was assessed in liquid as well as solid growth media. It was observed from scanning electron microscopic analysis that the interaction of copper nanoparticles with E. coli resulted in the formation of cavities/pits in the bacterial cell wall. The antibacterial property of copper nanoparticles was attributed mainly to adhesion with bacteria because of their opposite electrical charges, resulting in a reduction reaction at the bacterial cell wall. Nanoparticles with a larger surface-to-volume ratio provide more efficient means for antibacterial activity.
Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents (2009)

Coapplication of lidocaine and its quaternary derivative QX-314 produces a long-lasting, predominantly nociceptor-selective block, likely by facilitating QX-314 entry through TRPV1 channels. Delivery of QX-314 into nociceptors by using lidocaine instead of capsaicin produces sustained regional analgesia without nocifensive behavior.
Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer† (2008)

We identified a set of candidate oncogenes and tumor suppressor genes for human HCC. Our study provides evidence that inhibition of Spry activity cooperates with other oncogenes to promote liver cancer in mouse models, and Spry2 may function as a candidate tumor suppressor for HCC development in vivo. In addition, we demonstrate that the integration of genomic analysis and in vivo transfection is a powerful tool to identify genes that are important during hepatic carcinogenesis.