gebhart/patrepeval huggingface dataset:
P3-S7.08 Clinical evaluation of the APTIMA<sup>®</sup><i>Trichomonas vaginalis</i>assay on the TIGRIS<sup>®</sup>DTS<sup>®</sup>system in asymptomatic and symptomatic female subjects (2011)

Background This study evaluated the clinical performance of the APTIMA® Trichomonas vaginalis (ATV, Gen-Probe Incorporated) Assay, a nucleic acid amplification test for the diagnosis of Trichomonas vaginalis (TV) infection, in asymptomatic and symptomatic women. Methods This prospective, multicenter clinical trial enrolled 1025 women attending US OB-GYN, adolescent, family planning, or sexually transmitted disease clinics. Four specimen types were collected from each subject: physician-collected vaginal swab, endocervical swab, ThinPrep specimen, and first-catch urine. Of three vaginal swabs collected from each subject, one was used for wet mount microscopic examination, one for culture, and one for molecular testing for TV. The order of collection for each vaginal swab sample was rotated to minimise sampling bias. Each specimen was tested by ATV assay using the automated TIGRIS DTS system. ATV assay performance in each sample type was determined by comparing ATV assay test result to the patient infected status (positive in saline wet mount and/or culture) for each sample. Results Of 933 subjects included in the analysis, 59.9% were symptomatic. Compared to patient infected status, ATV assay clinical sensitivities and specificities were 100% and 99.0%, respectively, from vaginal swabs; 100% and 99.4%, respectively, from endocervical swab; 100% and 99.6%, respectively, from ThinPrep specimens; and 95.2% and 98.9%, respectively, from patient-collected urine samples. ATV assay performance was similar in asymptomatic and symptomatic patients, by age group (14–17 years and 18 years or older), and was consistent between testing sites. The ATV assay also demonstrated superior performance compared to wet mount microscopic examination and TV culture, regardless of the specimen type utilised. Conclusions This study provides clinical validation of the ATV assay for the intended uses of detecting TV rRNA in asymptomatic women, and/or to aid in the diagnosis of trichomoniasis in symptomatic women, in a US population. The use of highly accurate, fully-automated molecular tests such as the ATV assay for testing easily obtained vaginal swab and urine samples should facilitate large-scale screening for TV in the US.
Tunnel-injected ultraviolet light-emitting diodes (Conference Presentation) (2018)

We report on the design, demonstration and current status of tunnel-injected ultra-violet light emitting diodes (UV LEDs). III-Nitride ultraviolet light emitting diodes (UV LEDs) are promising in various applications including sterilization, water purification and medical sensing. However, both the light extraction efficiency and electrical efficiency face fundamental challenges for the conventional UV LED structures. This stems from the poor p-type conductivity and high p-type contact resistance. Hole injection using interband tunneling provides an elegant solution to the fundamental issues of UV LEDs, and can resolve both the hole injection and light extraction issues that have been the primary problems for UV LEDs. In this talk, we will discuss in detail the heterostructure design and demonstration through polarization engineering to realize efficient interband tunneling in ultra-wide band gap AlGaN material. We will then outline some of the growth and fabrication challenges, and discuss our approaches to overcome these. Finally, we will present our results on tunnel-injected UV LEDs that have enabled us to achieve efficient UV light emission in the UVA and UVB wavelength ranges with on-wafer efficiencies comparable to state-of-the-art values [1,2,3]. References: 1. Yuewei Zhang, et al. ''Interband tunneling for hole injection in III-nitride ultraviolet emitters", Appl. Phys. Lett. 106, 141103 (2015); 2. Yuewei Zhang, et al. "Design of p-type cladding layers for tunnel-injected UV-A light emitting diodes", Appl. Phys. Lett. 109, 191105 (2016); 3. Yuewei Zhang, et al. “Tunnel-injected sub-260 nm ultraviolet light emitting diodes”, Appl. Phys. Lett. 110, 201102 (2017).
Elastic filter based on coupled resonator waveguides in phononic crystal slabs (2010)

In this paper we demonstrate the possibility of forming a new elastic filter structure based on the coupled resonator waveguides in phononic crystal slabs (CRAW) with superior performance over the conventional filters. The structures are made by etching a honeycomb array of holes in a free standing slab. This phononic slab structure exhibits an absolute phononic band gap for all polarizations of guided waves inside the slab including the Lamb and Love waves. We present an analysis of a different family of waveguides in phononic-crystal slabs, and illustrate the considerations that must be applied to achieve single-mode guided bands in these structures. Consequently, an unusual family of selective elastic filters composed of several single resonators that are coupled periodically through evanescent waves is obtained. The elastic energy is localized in the extended defect formed by the collective coupled resonators. The frequencies of the filters are sensitive to the geometrical parameters and to the separation distance between the indiviual resonators. Numerical simulations are performed using the finite element method and considering Zinc-Oxide slab.
Exploiting the Textural Information of UAV Multispectral Imagery to Monitor Nitrogen Status in Rice (2019)

This study investigates the potential of texture analysis from the UAV-based multispectral imagery in qualifying N status in rice crops. Texture features and textural indices extracted from the UAV images were correlated with N-related variables. Results indicated that textural indices performed significantly better than individual texture features in N-related variables estimation. Textural indices performed better in plant level N-related variables than that in leaf level. With regards to texture analysis, direction vertical to the row orientation was recommended in row-planted crops. Those findings confirm that texture analysis from UAV imagery is a reliable technique in crop N status monitoring.
A Hybrid Proton-exchanged/Titanium-indiffuscd 2×2 Polarization Splitter in LiNbO3 (1992)

An integrated-optic polarization splitter is a necessary component in many integrated photonic devices, particularly in those devices, such as coherent receivers and optical filters, which achieve polarization independence by employing a polarization-diversity configuration [1-3]. A very versatile structure is the 2 × 2 beamsplitter which separates each of two input ports into orthogonally-polarized output ports.
Solvent-free mechanochemical synthesis of phosphonium saltsElectronic supplementary information (ESI) available: X-ray diffraction patterns of 1. See http://www.rsc.org/suppdata/cc/b1/b111515d/ (2002)

Phosphonium salts have been prepared during high-energy ball-milling of triphenylphosphine with solid organic bromides; the reactions occur at ambient conditions without a solvent; in the case of 2-bromo-2-phenylacetophenone the reaction in a solution usually produces a mixture containing both the C-phosphorylated and O-phosphorylated compounds, while the solvent-free mechanically induced transformation results in the thermodynamically favorable C-phosphorylated product; the occurrence of the observed transformations during mechanical processing of solid reactants is confirmed by the solid-state 31P NMR spectroscopy and X-ray powder diffraction.
Primary replication of a recombinant Sendai virus vector in macaques (2002)

An efficient antigen expression system using a recombinant Sendai virus (SeV) has been established recently and its potential to induce resistance against immunodeficiency virus infections in macaques has been shown. SeV replication has been well characterized in mice, the natural host, but not in primates, including humans. Here, primary SeV replication was investigated in macaques. After intranasal immunization with a recombinant SeV expressing simian immunodeficiency virus Gag protein, SeV-Gag, robust gag expression was observed in the nasal mucosa and much lower but significant levels of gag expression were observed in the local retropharyngeal and submandibular lymph nodes (LN). Expression peaked within a week and lasted at least up to 13 days after immunization. SeV-Gag was isolated from nasal swabs consistently at day 4 but not at all at day 13. Gag expression was undetectable in the lung as well as in remote lymphoid tissues, such as the thymus, spleen and inguinal LN, indicating that the spread of the virus was more restricted in macaques than in mice. SeV-specific T cells were detectable in SeV-immunized macaques at day 7. Finally, no naive macaques showed significant levels of anti-SeV antibodies in the plasma, even after living in a cage together with an acutely SeV-infected macaque for 5 weeks, indicating that SeV transmission from SeV-infected macaques to naive ones was inefficient. None of the SeV-immunized macaques displayed appreciable clinical manifestations. These results support the idea that this system may be used safely in primates, including humans.
Electroless Gold Plating Solution (1991)

SummaryThe behaviour of autocatalytic electroless gold plating baths contained DMAB as reducing agent was investigated by the cyclic voltammetry analysis method. It was found that autocatalytic electroless gold plating favourably proceeded at pH 13 or above, but cyanide ions greatly inhibited oxidation of DMAB. In the optimum bath condition, the deposition rate was about 2.0 μm/hr, and the electroless gold plating had fine crystal form of 1–5 μm in particle size and high adhesion strength at 9 g in gold wire bonding.
Preliminary findings on the use of pulsatile machine reperfusion of a placenta to improve the cord blood collection yield including primitive hematopoietic stem cell fractions (2009)

This article demonstrates for the first time that CB can be collected up to 39 hours after delivery with PMPR while maximizing CB collection including HSCs with primitive phenotypes.
Inhibition of bone resorption in tissue culture by H1-receptor antagonists (1983)

Mouse bone culture studies show that several representative H1-receptor antagonists, promethazine hydrochloride, pyrilamine maleate, tripelennamine hydrochloride, and diphenhydramine hydrochloride, inhibit parathyroid extract-stimulated bone resorption. The H2-receptor antagonists, metiamide and cimetidine, are ineffective. In view of the finding that histamine and histamine agonists did not stimulate bone resorption, it is unlikely that histamine receptors are involved in mediating parathyroid extract-stimulated bone resorption. Because H1-receptor antagonists bind to phospholipids and have been shown to influence membrane structure and function, it is suggested that they inhibit bone resorption by a mechanism that depends on their membrane-stabilizing effect.
Improving Prediction of Prostate Cancer Recurrence using Chemical Imaging (2015)

Precise Outcome prediction is crucial to providing optimal cancer care across the spectrum of solid cancers. Clinically-useful tools to predict risk of adverse events (metastases, recurrence), however, remain deficient. Here, we report an approach to predict the risk of prostate cancer recurrence, at the time of initial diagnosis, using a combination of emerging chemical imaging, a diagnostic protocol that focuses simultaneously on the tumor and its microenvironment, and data analysis of frequent patterns in molecular expression. Fourier transform infrared (FT-IR) spectroscopic imaging was employed to record the structure and molecular content from tumors prostatectomy. We analyzed data from a patient cohort that is mid-grade dominant - which is the largest cohort of patients in the modern era and in whom prognostic methods are largely ineffective. Our approach outperforms the two widely used tools, Kattan nomogram and CAPRA-S score in a head-to-head comparison for predicting risk of recurrence. Importantly, the approach provides a histologic basis to the prediction that identifies chemical and morphologic features in the tumor microenvironment that is independent of conventional clinical information, opening the door to similar advances in other solid tumors.
A Neural Network Approach to Context-Sensitive Generation of\n Conversational Responses (2015)

We present a novel response generation system that can be trained end to end\non large quantities of unstructured Twitter conversations. A neural network\narchitecture is used to address sparsity issues that arise when integrating\ncontextual information into classic statistical models, allowing the system to\ntake into account previous dialog utterances. Our dynamic-context generative\nmodels show consistent gains over both context-sensitive and\nnon-context-sensitive Machine Translation and Information Retrieval baselines.\n
Data from Development of Gene Expression–Based Score to Predict Sensitivity of Multiple Myeloma Cells to DNA Methylation Inhibitors (2023)

<div>Abstract<p>Multiple myeloma is a plasma cell cancer with poor survival, characterized by the clonal expansion of multiple myeloma cells (MMC), primarily in the bone marrow. Novel compounds are currently tested in this disease, but partial or minor patients' responses are observed for most compounds used as a single agent. The design of predictors for drug efficacy could be most useful to better understand basic mechanisms targeted by these drugs and design clinical trials. In the current study, we report the building of a DNA methylation score (DM score) predicting the efficacy of decitabine, an inhibitor of DNA methyltransferase (DNMT), targeting methylation-regulated gene expression. DM score was built by identifying 47 genes regulated by decitabine in human myeloma cell lines and the expression of which in primary MMCs of previously untreated patients is predictive for overall survival. A high DM score predicts patients' poor survival, and, of major interest, high sensitivity of primary MMCs or human myeloma cell lines to decitabine <i>in vitro</i>. Thus, DM score could be useful to design novel treatments with DMNT inhibitor in multiple myeloma and has highlighted 47 genes, the gene products of which could be important for multiple myeloma disease development. <i>Mol Cancer Ther; 11(12); 2685–92. ©2012 AACR</i>.</p></div>
Power management in high-level synthesis (1999)

In this paper, we present a power-management methodology targeted toward high-level synthesis of data-dominated behavioral descriptions. It is founded on the observation that variable assignment can significantly affect power-management opportunities in the synthesized architecture, i.e., variable assignment determines whether or not spurious operations get executed by functional units in the architecture. We introduce perfectly power managed architectures, whose functional units do not execute any spurious operations. We present a variable assignment technique which, when used in high-level synthesis, produces architectures which are perfectly power-managed. Unlike many previously proposed power-management techniques, our method does not add latches or any other circuitry in front of functional units or registers and is, therefore, free of the attendant performance penalty. Experimental results indicate savings of up to 52.5% (average 23.0%) in power consumption over already power-optimized architectures. The area overheads due to our technique are also low and averaged 2.5% for our examples.
Predicting Release of Formaldehyde from Cellulosic Textiles (1985)

Because of their low cost, availability, and effectiveness, the reaction products of formaldehyde and cyclic amides are generally used to impart durable press properties to textiles. Therefore, test methods for estimation of formaldehyde release from fabrics have received widespread attention. Sources of measurable formaldehyde release are residual formaldehyde from finishing, free formaldehyde from the established cellulose-ether equilibria, and formaldehyde produced by hydrolysis of the cellulose cross-links and non-cross-linking substituents during end use or testing. Test methods for release vary in their assessment of free and hydrolysis-induced formaldehyde on the basis of the relative severity of the incubation or extraction step. Determinations of formaldehyde are very precise, but interferences with accuracy of the analyses can occur in several of the methods. Selectivity, versatility, and scope of the various tests are detailed.
Data from Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer (2023)

<div>AbstractPurpose:<p>FOLFOX, FOLFIRI, or FOLFOXIRI chemotherapy with bevacizumab is considered standard first-line treatment option for patients with metastatic colorectal cancer (mCRC). We developed and validated a molecular signature predictive of efficacy of oxaliplatin-based chemotherapy combined with bevacizumab in patients with mCRC.</p>Experimental Design:<p>A machine-learning approach was applied and tested on clinical and next-generation sequencing data from a real-world evidence (RWE) dataset and samples from the prospective TRIBE2 study resulting in identification of a molecular signature, FOLFOX<i>ai</i>. Algorithm training considered time-to-next treatment (TTNT). Validation studies used TTNT, progression-free survival, and overall survival (OS) as the primary endpoints.</p>Results:<p>A 67-gene signature was cross-validated in a training cohort (<i>N</i> = 105) which demonstrated the ability of FOLFOX<i>ai</i> to distinguish FOLFOX-treated patients with mCRC with increased benefit from those with decreased benefit. The signature was predictive of TTNT and OS in an independent RWE dataset of 412 patients who had received FOLFOX/bevacizumab in first line and inversely predictive of survival in RWE data from 55 patients who had received first-line FOLFIRI. Blinded analysis of TRIBE2 samples confirmed that FOLFOX<i>ai</i> was predictive of OS in both oxaliplatin-containing arms (FOLFOX HR, 0.629; <i>P</i> = 0.04 and FOLFOXIRI HR, 0.483; <i>P</i> = 0.02). FOLFOX<i>ai</i> was also predictive of treatment benefit from oxaliplatin-containing regimens in advanced esophageal/gastro-esophageal junction cancers, as well as pancreatic ductal adenocarcinoma.</p>Conclusions:<p>Application of FOLFOX<i>ai</i> could lead to improvements of treatment outcomes for patients with mCRC and other cancers because patients predicted to have less benefit from oxaliplatin-containing regimens might benefit from alternative regimens.</p></div>
Research on the Signal Process of a Bell-Shaped Vibratory Angular Rate Gyro (2014)

A bell-shaped vibratory angular rate gyro, which is inspired by the Chinese traditional bell, is a kind of axisymmetric shell resonator gyroscope. Its sensitive element is a vibratory-like Chinese traditional bell, using a piezoelectric element on the wall of the vibrator to detect the standing wave's precession to solve the input angular rate. This work mainly studies the circuit system of a bell-shaped vibratory angular rate gyro. It discusses the process of circuit system design, analysis and experiment, in detail, providing the foundation to develop a bell-shaped vibratory angular rate gyro. Since the bell-shaped resonator's curved structure has the characteristics of large noise in the piezoelectric signal and large harmonics, this paper analyzes its working and signal detection method, then gives the whole plan of the circuit system, including the drive module, the detection module and the control loop. It also studies every part of the whole system, gives a detailed design and analysis process and proves part of the circuit system using digital simulation. At the end of the article, the test result of the circuit system shows that it can remove the disadvantages of the curved structure having large noise in the piezoelectric signal and large harmonics and is more effective at solving the input angular rate.
Method and means of directing an ion beam onto an insulating surface for ion implantation or sputtering. [Patent application] (1977)

A beam of ions is directed under control onto an insulating surface by supplying simultaneously a stream of electrons directed at the same surface in a quantity sufficient to neutralize the overall electric charge of the ion beam and result in a net zero current flow to the insulating surface. The ion beam is adapted particularly both to the implantation of ions in a uniform areal disposition over the insulating surface and to the sputtering of atoms or molecules of the insulator onto a substrate. 1 figure.
Maximizing the transparency advantage in optical networks (2003)

We enhance the potential cost savings from optical network transparency by applying connected dominating sets and impairment-aware routing, thus reducing the density of OEO nodes substantially below that obtained with more straightforward path improvement heuristics. The funding support of NIST ATP contract 70NANB8H4018 is gratefully acknowledged.
Microelectronic neural bridging of toad nerves to restore leg function. (2013)

The present study used a microelectronic neural bridge comprised of electrode arrays for neural signal detection, functional electrical stimulation, and a microelectronic circuit including signal amplifying, processing, and functional electrical stimulation to bridge two separate nerves, and to restore the lost function of one nerve. The left leg of one spinal toad was subjected to external mechanical stimulation and functional electrical stimulation driving. The function of the left leg of one spinal toad was regenerated to the corresponding leg of another spinal toad using a microelectronic neural bridge. Oscilloscope tracings showed that the electromyographic signals from controlled spinal toads were generated by neural signals that controlled the spinal toad, and there was a delay between signals. This study demonstrates that microelectronic neural bridging can be used to restore neural function between different injured nerves.
Human parathyroid antigen: characterization and localization with monoclonal antibodies. (1986)

A cell surface antigen on human parathyroid cells was identified by monoclonal antibodies. The antigen, called parathyroid antigen (PTA), is found on both of two major polypeptides (190 kDa and 160 kDa) apparently associated exclusively with parathyroid cells. To determine whether PTA was a suitable target for in vivo imaging, 125I-labeled anti-PTA was injected into nude mice bearing human parathyroid xenografts. IgG1 anti-PTA antibody showed excellent radiolocalization of the grafts, whereas IgM anti-PTA, containing the same variable domains as the IgG1 antibody, showed little specific binding. These results suggest that antibody isotype is an important parameter for the in vivo immunoscintigraphy of specific cellular antigens.
Front end ASIC for AGIPD, a high dynamic range fast detector for the European XFEL (2016)

The Adaptive Gain Integrating Pixel Detector (AGIPD) is a hybrid pixel X-ray detector for the European-XFEL. One of the detector's important parts is the radiation tolerant front end ASIC fulfilling the European-XFEL requirements: high dynamic range - from sensitivity to single 12.5keV-photons up to 10<sup>4</sup> photons. It is implemented using the dynamic gain switching technique with three possible gains of the charge sensitive preamplifier. Each pixel can store up to 352 images in memory operated in random-access mode at ≥ 4.5 MHz frame rate. An external vetoing may be applied to overwrite unwanted frames.