gebhart/patrepeval huggingface dataset:
An Acquired Inhibitor of Fibrin Stabilization Associated With Isoniazid Therapy: Clinical and Biochemical Observations (1974)

Abstract A patient who bled seriously while taking isoniazid was found to have an inhibitor of fibrin stabilization. The bleeding appeared to cease soon after the isoniazid was discontinued, although the plasma still contained potent inhibitor activity. This activity gradually disappeared over several weeks. The inhibitor was precipitated at 50% saturation with ammonium sulfate, migrated in the beta area on zone electrophoresis, and was found in the second peak on Sephadex G-200 gel filtration. Inhibitor activity persisted after heating to 90°C. Fibrinogen isolated from the patient’s plasma lacked factor XIII activity but did not contain measurable inhibitor activity. When the rate of incorporation of 14C-putrescine into casein was utilized to study the kinetics of the inhibitor, it was shown that the inhibitor acted reversibly and that it competed with the amine donor, 14C-putrescine. The mechanism whereby isoniazid led to the development of the inhibitor is unknown.
Valorization of Humin‐Based Byproducts from Biomass Processing—A Route to Sustainable Hydrogen (2013)

The synthesis of biomass-based top value-added chemical platforms, for example, 5-hydroxymethyl furfural, furfural, or levulinic acid from the acid-catalyzed dehydration of sugars results in high yields of insoluble by-products, referred to as humin. Valorization of humin by steam reforming for H2 is discussed. Both thermal and catalytic steam gasification were investigated systematically. Humin undergoes drastic changes under thermal pre-treatment to the gasification temperature. Alkali-metal-based catalysts were screened for the reactions. Na2 CO3 showed the highest activity and was selected for further study. The presence of Na2 CO3 enhances the gasification rate drastically, and gas-product analysis shows that the selectivity to CO and CO2 is 75% and 25%, respectively, which is a H2 /CO ratio of 2 (corresponding to 81.3% H2 as compared to the thermodynamic equilibrium). A possible process for the complete, efficient conversion of humin is outlined.
Investigation and Analysis of Sexual Harassment in Corporate Workplace of China (2012)

At present, sexual harassment in domestic workplace has a high probability of occurrence, which causes more and more attention. In this paper, the form of sexual harassment in workplace, and how to solve the sexual harassment were investigated and analyzed through questionnaires; and countermeasures and management suggestions were put forward from three aspects of corporate, employees and family.
Phosphorescence quenching of fac-tris(2-phenylpyridyl)iridium(<scp>iii</scp>) complexes in thin films on dielectric surfaces (2015)

We study the influence of the film thickness on the time-resolved phosphorescence and the luminescence quantum yield of fac-tris(2-phenylpyridyl)iridium(iii) [Ir(ppy)3]-cored dendrimers deposited on dielectric substrates. A correlation is observed between the surface quenching velocity and the quenching rate by intermolecular interactions in the bulk film, which suggests that both processes are controlled by dipole-dipole interactions between Ir(ppy)3 complexes at the core of the dendrimers. It is also found that the surface quenching velocity decreases as the refractive index of the substrate is increased. This can be explained by partial screening of dipole-dipole interactions by the dielectric environment.
Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis (1977)

The topical effects of N0164 (a phenyl phosphonate derivative which is a partially selective antagonist of prostagladin E2), indomethacin and triamcinolone acetonide have been shown to reduce the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema. Oxazolone sensitized Swiss Webster mice were used, ear erythema and ear weights being used as a measure of the anti-inflammatory response to the drugs. N0164 was also shown to have systemic anti-inflammatory activity after intraperitoneal injection.
Mapping New Territory. (2008)

The article reports on the developing gallery culture of New York City's Lower East Side. It is reported that the number of art galleries in the Lower East Side doubled in 2007 and that the opening of the New Museum of Contemporary Art in the area has bolstered interest the area. Several fledgling Lower East Side galleries are profiled including Sunday, Amy Smith-Stewart, and Never Work. Several art dealers who have relocated to the area explain their reasons for doing so including Janos Gat.
Adaptive Output Feedback Design Using Asymptotic Properties of LQG/LTR Controllers (2011)

This technical note introduces an observer-based adaptive output feedback tracking control design for multi-input-multi-output dynamical systems with matched uncertainties. The reported methodology exploits asymptotic behavior of LQG/LTR regulators. Sufficient conditions for closed-loop stability and uniform ultimate boundedness of the corresponding tracking error dynamics are formulated. This method is valid for systems whose nominal linearized dynamics are controllable and observable. We assume that the number of the system measured outputs (sensors) is greater than the number of the control inputs (actuators) and that the system output-to-input matrix product has full column rank. In this case, the system can be “squared-up” (i.e., augmented) using pseudo-control signals to yield relative degree one minimum-phase dynamics. Since it is known that the “squaring-up” problem is solvable for any controllable observable triplet (A, B, C), the proposed design is applicable to systems whose regulated output dynamics may be non-minimum phase or have a high relative degree. A simulation example is presented to demonstrate key design features.
Backpropagation and Kohonen Self-Organizing Feature Map in Bankruptcy Prediction (2011)

The back-propagation (BP) network and the Kohonen self-organizing feature map, selected as the representative types for the supervised and unsupervised artificial neural networks (ANN) respectively, are compared in terms of prediction accuracy in the area of bankruptcy prediction. Discriminant analysis and logistic regression are also performed to provide performance benchmarks. The findings suggest that the BP network is a better choice when a target vector is available. Advantages as well as limitations of the studied methods are also identified and discussed.
Pulvermetallurgische Bauelemente in der Verfahrenstechnik (1990)

Abstract Powder‐metallurgical components in process engineering. Applications of structural parts made by powder metallurgy can be found in nearly all kinds of industries, especially the automotive industry, and the electrical and electronics industry. This paper describes applications of porous P/M materials for chemical technologies. Quite well known are sintered metal filter elements of different sizes in the form of tubes, plates, and cartridges. Porous P/M materials can also be used as flame resistors and silencers, for the dispersion of gases in liquids, for drying processes, and for homogenisation of various products. Almost all technically interesting alloys are available for these elements. New applications for porous metal structures are under development for the use of catalytically active reactor beds in solid bed reactors. It was found that some reactor bed materials are themselves active as catalysts. In such a reactor, the temperature gradient is very small, so that chemical reactions can be controlled much more efficiently.
A multicomponent, elicitor‐inducible cystatin complex in tomato, <i>Solanum lycopersicum</i> (2007)

We assessed the ability of the fungal elicitor arachidonic acid to induce cystatin genes in tomato (Solanum lycopersicum), using a cDNA expression library from arachidonate-treated leaves. The cDNAs of two novel cystatins were isolated, coding for an approx. 11-kDa protein, SlCYS10; and for a 23.6-kDa protein, SlCYS9, bearing an N-terminal signal peptide and a long, 11.5-kDa extension at the C terminus. Both genes were induced by arachidonate but not by methyl jasmonate, an inducer of the 88-kDa eight-unit cystatin, multicystatin, accumulated in the cytosol of leaf cells upon herbivory. A truncated form of SlCYS9, tSlCYS9, was produced by deletion of the C-terminal extension to assess the influence of this structural element on the cystatin moiety. As shown by kinetic and stability assays with recombinant variants expressed in Escherichia coli, deleting the extension influenced both the overall stability and inhibitory potency of SlCYS9 against cysteine proteases of herbivorous organisms. These findings provide evidence for a multicomponent elicitor-inducible cystatin complex in tomato, including at least 10 cystatin units produced via two metabolic routes.
Self-Supervised GANs via Auxiliary Rotation Loss (2019)

Conditional GANs are at the forefront of natural image synthesis. The main drawback of such models is the necessity for labeled data. In this work we exploit two popular unsupervised learning techniques, adversarial training and self-supervision, and take a step towards bridging the gap between conditional and unconditional GANs. In particular, we allow the networks to collaborate on the task of representation learning, while being adversarial with respect to the classic GAN game. The role of self-supervision is to encourage the discriminator to learn meaningful feature representations which are not forgotten during training. We test empirically both the quality of the learned image representations, and the quality of the synthesized images. Under the same conditions, the self-supervised GAN attains a similar performance to state-of-the-art conditional counterparts. Finally, we show that this approach to fully unsupervised learning can be scaled to attain an FID of 23.4 on unconditional ImageNet generation.
Intravenous Versus Oral Administration of Amitriptyline in Patients With Major Depression (2000)

Antidepressants can be administered by different routes. Advantages for either the oral or the intravenous administration have been suggested from pharmacokinetic as well as from clinical points of view. Controlled comparison studies of the two routes do not provide unequivocal recommendations. In this investigation, amitriptyline was studied over a 4-week period consisting of a 2-week, double-blind/double-dummy phase with either oral (150 mg/day), high-dose intravenous (150 mg/day), or medium-dose intravenous (100 mg/day) treatment and a 2-week phase of open oral treatment in 80 patients with major depression. A psychopathologic assessment was made using the Hamilton Rating Scale for Depression, the Clinical Global Impressions Scale, the von Zerssen's "Befindlichkeitsskala," an adjective checklist, and a Visual Analog Scale. No significant differences were found concerning the mean scores of the rating scales or time of onset of action in the physicians' ratings. In the patients' self-ratings, there was an earlier therapeutic effect in the high-dose intravenous group. The number of improvers after 7 days was significantly higher in the high-dose intravenous group compared with both other groups. After 14 days, no significant differences in the numbers of improvers and responders between groups were detected. The results of this study do not clearly favor one of the tested options. The main differences found in this study seem to be dose-related rather than differentiating between oral and intravenous routes of administration.
60-GHz Circularly Polarized Antenna Array Made in Low-Cost Fabrication Process (2014)

Circularly polarized (CP) antenna operating in the unlicensed 60 GHz frequency range is useful for millimeter-wave radio and radar applications. In this letter, a 2 × 2 right-handed circularly polarized (RHCP) planar array is demonstrated by using four CP antenna elements. A single element has a gain of 7.5 dBiC, while the resulting 2 × 2 array yields a CP gain of 12.5 dBiC. Substrate integrated waveguide (SIW) cavity is used to back each element in order to reduce the mutual coupling between elements and also improve the overall gain. An experimental antenna prototype made through a conventional low-cost printed circuit board (PCB) technique operates in RHCP mode covering the frequency range of interest from 58 to 62 GHz. The antenna is compact, showing a good radiation performance.
A CMOS-Process-Compatible Low-Voltage Junction-FET With Adjustable Pinch-Off Voltage (2017)

A novel horizontal n-channel junction field-effect transistor (n-JFET) device is proposed and verified in a 0.25-μm bulk CMOS process. This horizontal JFET consists of alternating n-and p-regions formed by using the P-type electro-static discharge (ESD) implantation. P-type ESD implantation has been an optional and commonly well supported process step by most of foundriesto improve ESD robustness of the I/O devices. Device parameters such as the pinch-off voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">P</sub> ) and the zero-bias drain current (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS0</sub> ) of the proposed n-JFET device can be modified by adjusting the P+ separation (L) in the layout. With the adjustable pinch-off voltages, this device can be used for different circuit applications. The 2-D device simulations with technology computer aided design are used to analyze the depletion region and to verify the pinch-off voltage under different L values. The pinch-off voltage remains almost unchanged with the temperature variations. In addition, SPICE simulation results show good agreement with the experimental silicon (Si) data in term of I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> and I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G</sub> .
Disease and Medicine in the Middle Ages (1979)

Disease and Medicine in the Middle Ages Constance Dauber Jones, MT(ASCP) Constance Dauber Jones, MT(ASCP) Staff of El Camino Hospital, Mountain View, California. Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 10, Issue 1, 1 January 1979, Pages 54–58, https://doi.org/10.1093/labmed/10.1.54 Published: 01 January 1979
Purification to homogeneity of latent and active 58-kilodalton forms of human neutrophil collagenase (1990)

Latent and active 58-kDa forms of human neutrophil collagenase (HNC) have been purified to homogeneity. Buffy coats were extracted in the presence and absence of phenylmethanesulfonyl fluoride to generate crude starting preparations that contained latent and active HNC, respectively. The buffers used in preparing these extracts and for all subsequent chromatographic steps contained NaCl at a concentration of 0.5 M or greater, 0.05% Brij-35, concentrations of CaCl2 of 5 mM or greater, and (when feasible) 50 microM ZnSO4 to stabilize the HNC. The collagenase activity in the buffy coat extracts was adsorbed to a Reactive Red 120-agarose column at pH 7.5 in 0.5 M NaCl and was eluted when the NaCl concentration was increased to 1 M. The active and p-(chloromercuri)benzoate-activated latent enzymes were next adsorbed to a Sepharose-CH-Pro-Leu-Gly-NHOH affinity resin in 1 M NaCl at pH 7.5 and desorbed at pH 9 to give a fraction containing only HNC and a small amount of neutrophil gelatinase. The latter enzyme was removed by passage over a gelatin-Sepharose column in 1 M NaCl at pH 7.5. The purified samples of active and latent HNC were obtained with typical cumulative yields of 32 and 82% and specific activities toward soluble rat type I collagen at 30 degrees C of 7200 and 12,000 micrograms min-1 mg-1, respectively. These specific activities are markedly higher than previously reported for HNC. Both active and latent HNC exhibit a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis both in the presence and in the absence of 2-mercaptoethanol. The mobility of latent HNC is consistent with a molecular weight of approximately 58K, with the active form exhibiting a slightly lower (less than 1-2K) molecular weight.
MAM-RNN: Multi-level Attention Model Based RNN for Video Captioning (2017)

Visual information is quite important for the task of video captioning. However, in the video, there are a lot of uncorrelated content, which may cause interference to generate a correct caption. Based on this point, we attempt to exploit the visual features which are most correlated to the caption. In this paper, a Multi-level Attention Model based Recurrent Neural Network (MAM-RNN) is proposed, where MAM is utilized to encode the visual feature and RNN works as the decoder to generate the video caption. During generation, the proposed approach is able to adaptively attend to the salient regions in the frame and the frames correlated to the caption. Practically, the experimental results on two benchmark datasets, i.e., MSVD and Charades, have shown the excellent performance of the proposed approach.
NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury (2018)

Peripheral nerve lesions provoke apoptosis in the dorsal horn of the spinal cord. The cause of cell death, the involvement of neurons, and the relevance for the processing of somatosensory information are controversial. Here, we demonstrate in a mouse model of sciatic nerve injury that glutamate-induced neurodegeneration and loss of γ-aminobutyric acid (GABA)ergic interneurons in the superficial dorsal horn promote the transition from acute to chronic neuropathic pain. Conditional deletion of Grin1, the essential subunit of N-methyl-d-aspartate-type glutamate receptors (NMDARs), protects dorsal horn neurons from excitotoxicity and preserves GABAergic inhibition. Mice deficient in functional NMDARs exhibit normal nociceptive responses and acute pain after nerve injury, but this initial increase in pain sensitivity is reversible. Eliminating NMDARs fully prevents persistent pain-like behavior. Reduced pain in mice lacking proapoptotic Bax confirmed the significance of neurodegeneration. We conclude that NMDAR-mediated neuron death contributes to the development of chronic neuropathic pain.
Development of Catalytically Active Silver Colloid Nanoparticles Stabilized by Dextran (2011)

Colloidal silver nanoparticles (Ag-NPs) with a mean diameter of 6.1 nm and a narrow size distribution were prepared by reduction of the correspondent metal salt with injection of NaBH(4), in the presence of dextran, and characterized by UV-vis, TEM, and DLS. The concentration of all reactants involved in the formation of the nanoparticles was optimized with the use of a new multivariate method, which revealed a significant reduction in the number of experiments when compared with the vast majority of univariate methods described in the literature. The Ag-NPs-dextran composite was able to efficiently catalyze the p-nitrophenol reduction in water by NaBH(4) with a rate constant normalized to the surface area of the nanoparticles per unit volume (k(1)) of 1.41 s(-1) m(-2) L, which is higher than values ever reported for Ag-NPs catalytic systems.
Diagnostic criteria for an enzyme-linked immunosorbent assay for occult heartworm disease: standardization of the test system in naturally exposed dogs. (1984)

The development of criteria for interpreting and reporting the results of an occult heartworm enzyme-linked immunosorbent assay to practitioners is described. The antigen is a saline extract of adult female Dirofilaria immitis. The cutoff absorbance A400 nm values were estimated, using 106 dogs free of infection. Any A400 nm value less than 0.526 is considered negative and values greater than or equal to 0.784 are positive. Intermediate A400 nm values are interpreted as suspect. Absorbance values for serum samples from 13 client-owned amicrofilaremic dogs revealed a bimodal distribution consistent with presumptive diagnosis based on clinical signs, which indicates that the test may be used to support a diagnosis of occult heartworm disease. The present serotest, however, is unable to distinguish microfilaremic dogs from noninfected dogs. Serum from dogs infected with other common helminths failed to crossreact with the D immitis antigen, with the exception of Dipetalonema reconditum.
Major histocompatibility complex class I presentation of ovalbumin peptide 257–264 from exogenous sources: protein context influences the degree of TAP‐independent presentation (1996)

Peritoneal macrophages from C57BL/6 mice process antigens from bacteria or coated on polystyrene beads for presentation by major histocompatibility complex (MHC) class I molecules. To investigate this antigen processing pathway, peritoneal macrophages from homozygous TAP1-/- mice, which lack the transporter associated with antigen processing (TAP) and are defective in presenting endogenous antigens on MHC class I, were used. TAP1-/- or C57BL/6 macrophages were co-incubated with either bacteria or polystyrene beads containing the 257-264 epitope from ovalbumin [OVA(257-264)], which binds the mouse class I molecule Kb. The source of the OVA(257-264) epitope was either the Crl-OVA(257-264) (Crl-OVA) fusion protein, the maltose binding protein (MBP)-Crl-OVA fusion protein, native OVA or bacterial recombinant OVA (rOVA); Crl-OVA, MBP-Crl-OVA and rOVA were each expressed in bacteria, and Crl-OVA and MBP-Crl-OVA purified from bacterial lysates and native egg OVA were coated onto polystyrene beads. The data reveal that peritoneal macrophages from C57BL/6 and TAP1-/- mice can process bacteria expressing Crl-OVA, MBP-Crl-OVA and rOVA as well as beads coated with native OVA, purified Crl-OVA, and purified MBP-Crl-OVA and present OVA(257-264) for recognition by OVA(257-264)/Kb-specific T hybridoma cells, albeit with different relative processing efficiencies. The processing efficiency of TAP1-/- macrophages co-incubated with bacteria or beads containing Crl-OVA or MBP-Crl-OVA was reduced approximately three to five times compared to C57BL/6 macrophages, but OVA(257-264) was presented 100 times less efficiently when the source of OVA(257-264) was full-length OVA. Chloroquine inhibition studies showed a differential requirement for acidic compartments in C57BL/6 versus TAP1-/- macrophages, which also depended upon the source of the OVA (257-264) epitope (Crl-OVA versus full-length OVA). These data suggest that TAP1-/- and C57BL/6 macrophages may process Crl-OVA and full-length OVA in different cellular compartments and that the protein context of the OVA(257-264) epitope influences the extent of TAP-independent processing for MHC class I presentation.