gebhart/patrepeval huggingface dataset:
Implication of microRNA-148b in chronic obstructive lung disease of βENaC-overexpressing mice (2013)

MicroRNAs are involved in diverse biological and pathological processes. Here, we studied the potential role of miRNAs in the in vivo pathogenesis of chronic obstructive pulmonary disease (COPD) using βENaC-overexpressing (βENaC-Tg) mouse model. We performed miRNA array analysis in lung tissue of βENaC-Tg and wild-type (WT) mice. Differentially expressed miRNAs were validated by qRT-PCR and their functional importance was determined by bioinformatics analysis and in luciferase reporter assays. Tissue specific localization was performed by in situ hybridization using locked nucleic acid-modified DNA probe. Direct functional studies were performed by knockdown of miRNA expression in the lungs of βENaC-Tg mice using antagomirs. The effects of knockdown were studied by lung histology, pulmonary function testing using flexiVent system and analysis of inflammatory cells in bronchoalveolar lavage. We demonstrate that miR-148b is upregulated in the lungs of βENaC-Tg mice and predominantly localized in the conducting airways. Luciferase reporter assay in Hela cells suggests Mig-6 (mitogen inducible gene-6), a protein previously shown in normal lung development, as a potential target of miR-148b. Knockdown of miR-148b in the lung of βENaC-Tg mice results in reduced emphysema and decreased numbers of neutrophils compared to WT mice. Moreover, we observed upregulation of miR-148b in bronchial brushing of cystic fibrosis and COPD lung tissue from human. Taken together, these results indicate that dysregulation of miR-148b expression may play an important role in the pathogenesis of COPD and may serve as a novel therapeutic target. Supported by BMBF (82DZL00401).
Plenoptic Camera Resolution (2015)

To resolve the low resolution problem of Plenoptic cameras we analyze optical signal sampling at frequencies above Nyquist. The resultant aliased signal is superresolved interleaving the array of microimages, thus cancelling the aliasing components. The rendered image can reach full sensor resolution.
16.3: Directional Backlight Lightguide Considerations for Full Resolution Autostereoscopic 3D Displays (2010)

Abstract This paper will describe the requirements and considerations necessary to create a directional backlight suitable for use with a 3D film method for achieving full resolution autostereoscopic 3D displays in handheld and portable devices. A general overview and example will be given.
ChemInform Abstract: Synthesis of New Indeno[1,2‐c]isoquinolines: Cytotoxic Non‐Camptothecin Topoisomerase I Inhibitors. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chelation And Extraction Of Metals For GC-MS Analysis (1995)

Chelation followed by supercritical-fluid extraction enables mass-spectrometric analysis. When fully developed, method implemented in field-portable apparatus for detection and quantification of metals in various matrices without need for elaborate preparation of samples. Used to analyze soil samples for toxic metals.
Site‐selective cyclic AMP analogs provide a new approach in the control of cancer cell growth (1987)

Site-selective cyclic AMP analogs bind to site 1 or site 2 of the known cAMP-binding sites depending on the position of substituents on the purine ring, either at C-2 and C-8 (site 1) or at C-6 (site 2). The growth inhibitory effect of such site-selective cAMP analogs used in this investigation with 15 human cancer cell lines surpassed that of analogs previously tested. The most potent analogs were 8-chloro, N6-benzyl and N6-phenyl-8-p-chlorophenylthio-cAMP. The combination of a C-8 with an N6 analog had synergistic effects. The 24 site-selective analogs tested produced growth inhibition ranging from 30 to 80% at micromolar concentrations with no sign of toxic effects. Growth inhibition was not due to a block in a specific phase of the cell cycle but paralleled a change in cell morphology, an increase of the RII cAMP receptor protein and a decrease of p21 ras protein. Since the adenosine counterpart of the 8-chloro analog produced G1 synchronization without affecting the RII and p21 ras protein levels, it is unlikely that an adenosine metabolite is involved in the analog effect. Site-selective cAMP analogs thus provide a new biological tool for control of cancer growth.
Granulocytic Myeloid-Derived Suppressor Cells in Breast Milk (BM-MDSC) Correlate with Gestational Age and Postnatal Age and Are Influenced by Infant’s Sex (2020)

Our results point toward a role of BM-MDSC for immune regulation in the neonatal gut, making them a potential target of immune-based therapies shortly after birth.
Lithium Aluminosilicate Optical Fiber For Brillouin-Based Distributed Sensing (2016)

The thermal response of Brillouin scattering in optical fibers using Group I (lithium) aluminosilicate glass can be tailored across a remarkably wide range. This enables new applications for Brillouin-based distributed sensing using silica fibers.
Relaxed-currency serializability for middle-tier caching and replication (2006)

Many applications, such as e-commerce, routinely use copies of data that are not in sync with the database due to heuristic caching strategies used to enhance performance. We study concurrency control for a transactional model that allows update transactions to read out-of-date copies. Each read operation carries a "freshness constraint" that specifies how fresh a copy must be in order to be read. We offer a definition of correctness for this model and present algorithms to ensure several of the most interesting freshness constraints. We outline a serializability-theoretic correctness proof and present the results of a detailed performance study.
Method for intensity correction in CR mosaic by combined nonlinear and linear transformations (2003)

In this paper, we present a method to correct for intensity artifacts in mosaic composition of Computed Radiography (CR) images. The white band artifacts not only distort diagnostic information, but also cause visual disturbances in the examination by physicians. We propose a hybrid method to enhance the image intensity and to correct the brightness differences. A nonlinear transformation method is presented for enhancement, whereas a linear regression method is utilized to compensate for the intensity differences between the white band and normal exposure regions. A knowledge-based method is proposed which can autonomously decide whether the nonlinear enhancement step needs to be bypassed, since in some cases over-enhancement may result from the correction algorithm. Experimental results with different images are presented to show the effectiveness of the proposed method.
Live Ultrasound Color-Encoded Speckle Imaging Platform for Real-Time Complex Flow Visualization <italic>In Vivo</italic> (2019)

Complex flow patterns are prevalent in the vasculature, but they are difficult to image noninvasively in real time. This paper presents the first real-time scanning platform for a high-frame-rate ultrasound technique called color-encoded speckle imaging (CESI) and its use in visualizing arterial flow dynamics in vivo. CESI works by simultaneously rendering flow speckles and color-coded flow velocity estimates on a time-resolved basis. Its live implementation was achieved by integrating a 192-channel programmable ultrasound front-end module, a 4.8-GB/s capacity data streaming link, and a series of computing kernels implemented on the graphical processing unit (GPU) for beamforming and Doppler processing. A slow-motion replay mode was also included to offer coherent visualization of CESI frames acquired at high frame rate [3000 frames per second (fps) in our experiments]. The live CESI scanning platform was found to be effective in facilitating real-time image guidance (at least 20 fps for live video display with 55-fps GPU processing throughout). In vivo pilot trials also showed that live CESI, when running in replay mode, can temporally resolve triphasic flow at the brachial bifurcation and can reveal flow dynamics in the brachial vein during a fist-clenching maneuver. Overall, live CESI has potential for use in routine investigations in vivo that seek to identify complex flow dynamics in real time and relate these dynamics to vascular physiology.
Structure−Activity Relationship of 2-Oxoamide Inhibition of Group IVA Cytosolic Phospholipase A<sub>2</sub>and Group V Secreted Phospholipase A<sub>2</sub> (2007)

The Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is a key provider of substrates for the production of eicosanoids and platelet-activating factor. We explored the structure-activity relationship of 2-oxoamide-based compounds and GIVA cPLA2 inhibition. The most potent inhibitors are derived from delta- and gamma-amino acid-based 2-oxoamides. The optimal side-chain moiety is a short nonpolar aliphatic chain. All of the newly developed 2-oxoamides as well as those previously described have now been tested with the human Group V secreted PLA2 (GV sPLA2) and the human Group VIA calcium-independent PLA2 (GVIA iPLA2). Only one 2-oxoamide compound had appreciable inhibition of GV sPLA2, and none of the potent GIVA cPLA2 inhibitors inhibited either GV sPLA2 or GVIA iPLA2. Two of these specific GIVA cPLA2 inhibitors were also found to have potent therapeutic effects in animal models of pain and inflammation at dosages well below the control nonsteroidal anti-inflammatory drugs.
Heat shock protein receptors: Implications for vaccination (2003)

Heat shock protein (hsp)-peptide complexes are taken up by dendritic cells through hsp receptors such as CD91. Endocytosed hsp-peptide complexes are re-presented (or cross-presented) by the DCs through their MHC I (and to a lesser extent, MHC II) molecules. In an analysis of re-presentation of ovalbumin-derived SIINFEKL peptides from ova-expressing E.G7 cells, we observe that the hsp-peptide complexes and not the ova protein are the dominant form of antigen utilized in re-presentation. These observations and other considerations (to be discussed at the meeting) lead us to explore the hypothesis that hsp-peptide complexes represent a dominant instrument of cross-presentation and cross-priming in vivo . 

This abstract was published in Cancer Immunity , a [Cancer Research Institute][1] journal that ceased publication in 2013 and is now provided online in association with Cancer Immunology Research .

 [1]: http://cancerresearch.org/
<title>New gyroscope concept using fiber laser interferometer</title> (1996)

We report a new type of gyroscope using a fiber laser with a simple configuration. It consists of a Fabry-Perot type fiber laser and an interferometer which is used to combine tow output beams from both mirrors of the laser. The rotation rate is obtained from the change of the phase difference between the two output beams. The experimental results are in good agreements with theoretical predictions.
Photoinduced Charge Separation and Charge Recombination to a Triplet State in a Carotene−Porphyrin−Fullerene Triad (1997)

A molecular triad consisting of a diarylporphyrin (P) covalently linked to a carotenoid polyene (C) and a fullerene (C60) has been prepared and studied using time-resolved spectroscopic methods. In 2-methyltetrahydrofuran solution, the triad undergoes photoinduced electron transfer to yield C−P•+−C60•-, which evolves into C•+−P−C60•- with an overall quantum yield of 0.14. This state decays by charge recombination to yield the carotenoid triplet state with a time constant of 170 ns. Even in a glass at 77 K, C•+−P−C60•- is formed with a quantum yield of ∼0.10 and again decays mainly by charge recombination to give 3C−P−C60. The fullerene triplet, formed through normal intersystem crossing, is also observed at 77 K. The generation in the triad of a long-lived charge separated state by photoinduced electron transfer, the low-temperature electron transfer behavior, and the formation of a triplet state by charge recombination are phenomena previously observed mostly in photosynthetic reaction centers.
Preparation of Chlorodifluoroamine, NF<sub>2</sub>Cl (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Chlorodifluoroamine, NF2ClT. A. Austin and R. W. MasonCite this: Inorg. Chem. 1963, 2, 3, 646–647Publication Date (Print):June 1, 1963Publication History Published online1 May 2002Published inissue 1 June 1963https://doi.org/10.1021/ic50007a060RIGHTS & PERMISSIONSArticle Views26Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (265 KB) Get e-Alerts Get e-Alerts
Novel Method and Device for Fully Non-Invasive Cerebrovascular Autoregulation Monitoring (2014)

The novel method and the device for non - invasive cerebrovascular autoregulation (CA) status monitoring without using the arterial blood pressure (ABP) measurement channel are presented. This fully non-invasive CA monitor is based on the ultrasonic time-of-flight measurement of cerebral blood volume pulsations within the brain parenchyma, extraction of informative and reference slow and respiratory volumetric waves and calculation of CA estimating indexes without using any additional ABP measurements.For demonstrating the applicability of the proposed method, the CA status was monitored on 11 traumatic brain injury patients simultaneously by using the novel fully non-invasive monitor and compared to the CA status representing indexes calculated from the invasively measured intracranial pressure (ICP) and ABP slow waves. The total monitoring time was about 22 hrs. The correlation factor between the invasively and non-invasively obtained CA data showed significant agreement (r=0.751) between the two methods.The proposed innovative CA real-time monitoring method gives us new possibilities to perform estimation of the CA status from the intracranial waves only as well as to exclude the ABP line’s errors and artifacts from the measurement results.DOI: http://dx.doi.org/10.5755/j01.eee.20.8.5464
Surface and antitumor activity of some novel metal-based cationic surfactants (2007)

The development of anticancer metal-based drugs was attempted by reacting dodecyl amine with selenious acid to produce a quaternary ammonium salt which was then converted to copper and cobalt cationic complexes via complexing the first compounds with copper (II) or cobalt (II) ions. The surface properties of these surfactants were investigated. The surface properties studied included critical micelle concentration (CMC), maximum surface excess (Gamma max ), and minimum surface area (A min ). Free energy of micellization (Delta G degree mic ) and adsorption (Delta G degree ads ) were calculated. Antitumor activity was tested by using Ehrlich ascites carcinoma (EAC) as a model system of mice cell tumor. The compounds were also tested in vitro on five human monolayer tumor cell lines: MCF 7 (breast carcinoma), HEPG 2 (liver carcinoma), U 251 (brain tumor), HCT 116 (colon carcinoma), and H 460 (lung carcinoma). FTIR spectra, elemental analysis, and H 1 NMR spectra were performed to insure the purity of the prepared compounds.
First Synthesis of EuS Nanoparticle Thin Film with a Wide Energy Gap and Giant Magneto-Optical Efficiency on a Glass Electrode (2012)

Novel magneto-optical thin films composed of europium sulfide (EuS) nanoparticles on a glass electrode exhibit large magneto-optical efficiency and a wide energy gap. EuS nanoparticle thin films are prepared by the electrochemical reduction of a single-source precursor, a Eu(III) dithiocarbamate complex (tetraphenylphosphonum tetrakis(diethyldithiocarbamate) europium(III)). The EuS nanoparticle thin films were prepared on indium–tin oxide (ITO)-coated glass electrodes and characterized by electrochemical analysis, scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, laser scanning microscopy, and absorption spectroscopy. Faraday rotation spectra for estimation of the magneto-optical efficiency have clear positive and negative peaks, which are attributed to the 4f–5d transitions of the EuS thin films. The positive and negative peaks of the Faraday rotation spectrum are 525 and 680 nm, which are directly related to the energy gap of the EuS nanoparticle thin film (2.4 eV). That spectrum indicates that the EuS nanoparticle thin films are blue shifted in comparison with 7 nm diameter EuS nanoparticles (2.2 eV). The Verdet constant of the thin film was 11 mdeg/cm Oe at 525 nm, which is approximately 10 times larger than that of previously reported EuS nanoparticles.
Hybrid micro-particles as a magnetically-guidable decontaminant for cesium-eluted ash slurry (2014)

Decontamination of the radioactive cesium that is widely dispersed owing to a nuclear power station accident and concentrated in fly ash requires an effective elimination system. Radioactive fly ash contains large amounts of water-soluble cesium that can cause severe secondary contamination and represents a serious health risk, yet its complete removal is complicated and difficult. Here it is shown that a new fine-powder formulation can be magnetically guided to eliminate cesium after being mixed with the ash slurry. This formulation, termed MagCE, consists of a ferromagnetic porous structure and alkaline- and salt-resistant nickel ferrocyanide. It has potent cesium-adsorption- and magnetic-separation-properties. Because of its resistance against physical and chemical attack such as with ash particles, as well as with the high pH and salt concentration of the ash slurry, MagCE simplifies the decontamination process without the need of the continued presence of the hazardous water-soluble cesium in the treated ash.
Vacuum pyrolysis of used tires (1995)

The vacuum pyrolysis of used tires enables the recovery of useful products, such as pyrolytic oil and pyrolytic carbon black (CB{sub P}). The light part of the pyrolytic oil contains dl-limonene which has a high price on the market. The naphtha fraction can be used as a high octane number component for gasoline. The middle distillate demonstrated mechanical and lubricating properties similar to those of the commercial aromatic oil Dutrex R 729. The heavy oil was tested as a feedstock for the production of needle coke. It was found that the surface morphology of CB{sub P} produced by vacuum pyrolysis resembles that of commercial carbon black. The CB{sub P} contains a higher concentration of inorganic compounds (especially ZnO and S) than commercial carbon black. The pyrolysis process feasibility looks promising. One old tire can generate upon vacuum pyrolysis, incomes of at least $2.25 US with a potential of up to $4.83 US/tire upon further product improvement. The process has been licensed to McDermott Marketing Servicing Inc. (Houston) for its exploitation in the US.
Investigating the impact of Cryogenic Carbon Capture on power plant performance (2015)

Cryogenic Carbon Capture (CCC) is a CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> mitigation process that can be integrated into existing baseline and load following fossil-fueled power plants. This process consumes less energy than conventional chemical absorption and includes energy storage capability. The CCC process has a fast response time to load changes to allow higher utilization of intermittent renewable power sources to be used at a grid-scale level in the power sector. The impact of the CCC process on the performance and operating profit of a single fossil-fueled power generation unit is studied in this paper. The proposed system (power production from wind, coal, and natural gas) meets the total electricity demand with 100% utilization of the available wind energy. The operational strategy for the hybrid energy-carbon capture system and the change in the performance of the hybrid system due to the seasonal changes are also examined in this paper. A sensitivity analysis is implemented to investigate the change in operating strategy of the hybrid system based on the relative fraction of wind energy adoption. The optimal wind energy adoption factor in the proposed system is obtained.
Inhibition of LPS-responses by synthetic peptides derived from LBP associates with the ability of the peptides to block LBP-LPS interaction (2003)

The ability of LPS-binding protein (LBP) to greatly potentiate cell responses to lipopolysaccharide (LPS) may largely contribute to LPS toxicity in sepsis. The study of agents with the capacity to block the interaction between LBP and LPS might improve the understanding of the role of LBP in Gram-negative infections as well as offering new therapeutic tools for septic disorders. Here we confirm the ability of synthetic peptides comprising the human LBP amino acid region 86-108 to interfere with the LBP-LPS interaction. The analysis of selected alanine mutants of a blocking peptide corresponding to the LBP region 86-99 suggests the importance of peptide amphipathicity for the inhibitory activity. The potency of the native peptide and a selected analogue at inhibiting in vitro and in vivo LPS-induced responses was associated with their relative activity in blocking LBP-LPS interaction. It was remarkable that these peptides were at least 500-fold more active in vivo than in vitro. Also, the inhibitory activity of peptides LBP86-99 and LBPK95A seems to be independent of LBP concentrations, a behavior that may be relevant for the potential use of these peptides in septic disorders where LBP serum concentrations are considerably elevated.