gebhart/patrepeval huggingface dataset:
Detection of HLA-DR antigens in paraffin-embedded thyroid epithelial cells with a monoclonal antibody. (1985)

The human Class II major histocompatibility (MHC) antigens, or Ia antigens, which are thought to regulate immune cell interaction, can be detected in paraffin-embedded tissues by immunoperoxidase staining with a recently developed monoclonal antibody (LK8D3). HLA-DR antigens were observed in lymphoid tissues, Langerhans cells of the skin, some epithelial cells, and pulmonary alveolar macrophages. The expression of HLA-DR antigens was analyzed in formalin-paraffin sections by immunoperoxidase in 86 normal and abnormal thyroid epithelial tissues. All patients with Hashimoto's disease (8/8) and most patients with Graves' disease (6/8) expressed HLA/DR antigens in the thyroid epithelial cells and in adjacent inflammatory cells. Most papillary carcinomas (12/18), including 3 of 5 follicular variant of papillary thyroid carcinomas, had HLA-DR antigens detected in epithelial cells; whereas medullary thyroid carcinomas (0/5), follicular carcinomas (0/5), and multinodular goiters (0/4) did not have detectable HLA-DR immunoreactivity. A few other thyroid lesions had HLA-DR antigens detected in epithelial cells, including anaplastic carcinomas (2/5), Hurthle-cell tumors (1/16), and thyroid lymphomas (2/2). Monoclonal antibody LK8D3 and two other commercially available monoclonal antibodies against HLA-DR-stained tissues equally well in cryostat sections, but only antibody LK8D3 was effective in formalin-fixed paraffin-embedded tissue sections. These results indicate that epithelial cells from thyroids of patients with autoimmune diseases commonly express HLA-DR antigens. The presence of HLA-DR antigens in most papillary thyroid carcinomas may be helpful diagnostically in cases of follicular variants of papillary carcinomas. The role of HLA-DR expression in autoimmune thyroid disease and in papillary thyroid carcinoma remains to be determined.
Demonstration of a radiation resistant, high efficiency SiC betavoltaic (2006)

A SiC p-i-n junction betavoltaic was fabricated, and electrical power output under irradiation from an 8.5GBq P33 source was monitored over a period of four half-lives of the radioisotope. The open-circuit voltage (VOC) of the device was 2.04±0.02V, and the peak power (Pout) was 0.58±0.02μW (2.1±0.2μW∕cm2) at 1.60V. The conversion efficiency (ηconv) was 4.5%±0.3% and the normalized power output indicates no device degradation over more than 3months (four half-lives of the source).
Feedforward Control of Deformable Membrane Mirrors for Adaptive Optics (2012)

In this paper, performance enhancements for deformable membrane mirrors based on model-based feedforward control are presented. The investigated deformable mirror consists of a flexible membrane and voice coil actuators. Feedback control of the distributed actuators cannot be implemented in these mirrors due to a lack of high speed internal position measurements of the membrane's deformation. However, by using feedforward control, the dominant dynamics of the membrane can still be controlled allowing for faster settling times and reduced membrane vibrations. Experimental results are presented for an ALPAO deformable mirror with 88 distributed actuators on a circular membrane with a pupil of two centimeters in diameter.
Acute Toxoplasmic Encephalitis in a Normal Adult (1983)

Acute encephalitis associated with an impressive skin rash developed in an otherwise healthy man. Brain biopsy findings were not diagnostic, but serologic data confirmed the diagnosis of acute toxoplasmosis. The patient improved after antimicrobial therapy with pyrimethamine and sulfadiazine, but he was left with neurologic deficits.
Mutual Coupling Reduction in an Array of Patch Antennas Using CLL Metamaterial Superstrate for MIMO Applications (2018)

The capability of a magnetodielectric superstrate to suppress the surface wave propagation is investigated. It is shown that the capacitively loaded loop (CLL) metamaterial (MTM) superstrate exhibits a high degree of surface wave attenuation. One of the important applications of such structure is to reduce the mutual coupling between the microstrip patch elements in array antennas. The results of numerical simulations show a significant reduction in the mutual coupling between the antenna elements. To verify and confirm the simulation results, a prototype of the CLL-MTM superstrate incorporating an array of rectangular patch antennas are fabricated and tested. The proposed two-element array antenna has a dimension of approximately 1.6λ × 0.9λ × 0.16λ while achieving a gain and an efficiency of 8.2 dB and 97%, respectively. Measurement shows the mutual coupling reduction of over 55 dB. The CLL-MTM superstrate provides the gain and efficiency almost the same of unloaded array antennas with 0.1 dB and 2% changes, respectively.
Heterobi- and Heterotetranuclear RuRh and RuIr Complexes with 2,2'-Biimidazolate and 2,2'-Bibenzimidazolate Anions as Bridging Ligands (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeterobi- and Heterotetranuclear RuRh and RuIr Complexes with 2,2'-Biimidazolate and 2,2'-Bibenzimidazolate Anions as Bridging LigandsDaniel Carmona, Joaquina Ferrer, Ana Mendoza, Fernando J. Lahoz, Luis A. Oro, Fernando Viguri, and Josefa ReyesCite this: Organometallics 1995, 14, 4, 2066–2080Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/om00004a069https://doi.org/10.1021/om00004a069research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
New CCII Current Conveyor (2008)

Abstract: Offering higher bandwidth than its voltage-feedback counterpart, the second-generation current conveyor operational amplifier (CCII) can be used in RF mixers, high-frequency precision rectifiers, and medical applications such as electrical impedance tomography. The conventional operational amplifiers cannot be used in the high-frequency applications due to their limited gain-bandwidth product.
The effect of population structure on the rate of convergence of genetic algorithms (1993)

In this paper, we compare the performance of genetic algorithms using several different population structures: one large population of 200 individuals; 20 subpopulations of 10 individuals with or without migration; and 20 subpopulations of 10 individuals with periodic migration. We show that the performance of these population structures is dependent on the geome~of the given problem's search space. We apply these structures to several problems with different solution space structures. We address the following issues: (1) does population structure affect the rate of convergence to the solution?; and (2) if so, does the best population structure depend on the nature of the problem?
Diagnosis and management of female urinary incontinence in general practice. (1989)

In response to an invitation sent to women who had complained previously of regular incontinence, 65 women with regular incontinence were seen by their general practitioner. A diagnosis was made using a personally administered questionnaire and appropriate examination. Patients were placed in one of three diagnostic/management categories--stress, urge or stress/urge incontinence--and were given an appropriate treatment programme. Fifty six women were recruited as matched controls from non-responders while attending the surgery for other reasons. They underwent identical entry procedures but were not offered a treatment programme. All the patients were reassessed after 12 weeks at which time significant improvement in incontinence was reported by the treated women in the stress and urge categories compared with the controls. There was no significant difference in reported efficacy of treatment between age groups and treatment was shown to be effective irrespective of the duration of incontinence. This study shows that for the majority of women reporting incontinence the condition can be diagnosed by a general practitioner and significantly improved by appropriate intervention.
The Yin and Yang of Interleukin-2–Mediated Immunotherapy (2011)

In this issue of the Journal, the findings of two case series suggest that in vivo treatment with interleukin-2 can suppress immune-mediated diseases. In one study, Koreth et al.1 found that low-dose interleukin-2 was associated with reversal of glucocorticoid-refractory chronic graft-versus-host disease (GVHD) in patients who had undergone allogeneic hematopoietic stem-cell transplantation (HSCT) for the treatment of lymphomas and leukemias. The control of chronic GVHD was not accompanied by the relapse of cancer in any patient.1 In a second small case series, Saadoun et al.2 found that treatment of patients with hepatitis C virus (HCV)–related vasculitis with low-dose interleukin-2 led . . .
Chimeric antigen receptor T cell therapy targeting NKG2D ligand. (2016)

e14523 Background: Chimeric antigen receptor T cell (CAR-T) therapy is promising immunotherapy for cancer. While CAR-T therapy has shown encouraging results against CD19 in acute lymphoblastic lymphoma and other hematologic malignancies, CAR-T therapy targeting solid tumors is having problem with shortage of appropriate target antigens. NKG2D ligand (NKG2DL) is a ligand of NKG2D, which is expressed mainly on NK and γδ T cells, could be an attractive target of CAR-T therapy. NKG2DL such as MICA, MICB, and ULBP1 (UL16 binding protein 1) to ULBP3 are reported to be expressed on several kinds of tumors. Expression of MICA/MICB on tumor cells are reported to correlate with poor prognosis. Here we demonstrate that co-expressions of ULBP1 in cancer and NKG2D in peripheral blood mononuclear cells are associated with better prognosis in gastric cancer. For further analysis, we are investigating whether NKG2DL is appropriate target and which one among NKG2DL is able to be a target for the CAR-T therapy. Methods: We retrospectively reviewed the ULBP1 expression on tumor cells and the NKG2D expression on tumor infiltrating mononuclear cells by immunohistochemical staining in 98 specimens of surgically resected gastric cancer with cases of MP or deeper invasion depth. We also evaluated the correlation of ULBP1 and/or NKG2D expressions and its clinical outcome. Anti-tag(AT)-CAR-T therapy system which our group has been developing was used for this analysis. AT-CAR gene is transferred to activated T cells. ULBP1 and MICA expression vector was made by pcDNA 3.1. This vector was transfected to the SW480 human colon cancer cell line and A549 human lung cancer cell line by lipofection. Cytotoxicity by AT-CAR-T against tumor cells are evaluated using Terascan-VPC and EVOS. Results: Cases with both ULBP1 and NKG2D positive (n = 12) had better clinical outcome than those with doubly negative (n = 21) (5-year survival rate 90% vs 34%; Log-rank P < 0.05). We successfully set up cytotoxic assay for AT-CAR-T system. We also made the ULBP1 and MICA expression vector and tumor cells lines expressing ULBP1 and MICA in SW480. Conclusions: We are analyzing the cytotoxicity against tumor cell line targeting ULBP1 and/or MICA using CAR-T therapy.
Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer (2017)

Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active promoters and is associated with oncogene activation in prostate cancer, but its role in enhancer function is still poorly understood. Here we show that H2A.Zac containing nucleosomes are commonly redistributed to neo-enhancers in cancer resulting in a concomitant gain of chromatin accessibility and ectopic gene expression. Notably incorporation of acetylated H2A.Z nucleosomes is a pre-requisite for activation of Androgen receptor (AR) associated enhancers. H2A.Zac nucleosome occupancy is rapidly remodeled to flank the AR sites to initiate the formation of nucleosome-free regions and the production of AR-enhancer RNAs upon androgen treatment. Remarkably higher levels of global H2A.Zac correlate with poorer prognosis. Altogether these data demonstrate the novel contribution of H2A.Zac in activation of newly formed enhancers in prostate cancer.
Phase III Trial of Pemetrexed Plus Best Supportive Care Compared With Best Supportive Care in Previously Treated Patients With Advanced Malignant Pleural Mesothelioma (2008)

Second-line pemetrexed elicited significant tumor response and delayed disease progression compared with BSC alone in patients with advanced MPM. Improvement in OS was not seen in this study, possibly because of the significant imbalance in postdiscontinuation chemotherapy between the arms.
Fabrication, Functionalization, and Application of Electrospun Biopolymer Nanofibers (2008)

The use of novel nanostructured materials has attracted considerable interest in the food industry for their utilization as highly functional ingredients, high-performance packaging materials, processing aids, and food quality and safety sensors. Most previous application interest has focused on the development of nanoparticles. However, more recently, the ability to produce non-woven mats composed of nanofibers that can be used in food applications is beginning to be investigated. Electrospinning is a novel fabrication technique that can be used to produce fibers with diameters below 100 nm from (bio-) polymer solutions. These nanofibers have been shown to possess unique properties that distinguish them from non-woven fibers produced by other methods, e.g., melt-blowing. This is because first the process involved results in a high orientation of polymers within the fibers that leads to mechanically superior properties, e.g., increased tensile strengths. Second, during the spinning of the fibers from polymer solutions, the solvent is rapidly evaporated allowing the production of fibers composed of polymer blends that would typically phase separate if spun with other processes. Third, the small dimensions of the fibers lead to very high specific surface areas. Because of this the fiber properties may be greatly influenced by surface properties giving rise to fiber functionalities not found in fibers of larger sizes. For food applications, the fibers may find uses as ingredients if they are composed solely of edible polymers and GRAS ingredients, (e.g., fibers could contain functional ingredients such as nutraceuticals, antioxidants, antimicrobials, and flavors), as active packaging materials or as processing aids (e.g., catalytic reactors, membranes, filters (Lala et al., 2007), and sensors (Manesh et al., 2007; Ren et al., 2006; Sawicka et al., 2005). This review is therefore intended to introduce interested food and agricultural scientists to the concept of nano-fiber manufacturing with a particular emphasis on the use of biopolymers. We will review typical fabrication set-ups, discuss the influence of process conditions on nanofiber properties, and then review previous studies that describe the production of biopolymer-based nanofibers. Finally we briefly discuss emerging methods to further functionalize fibers and discuss potential applications in the area of food science and technology.
Structural basis of polyamine-DNA recognition: spermidine and spermine interactions with genomic B-DNAs of different GC content probed by Raman spectroscopy (2000)

Four genomic DNAs of differing GC content (Micrococcus luteus, 72% GC; Escherichia coli, 50% GC; calf thymus, 42% GC; Clostridium perfringens, 27% GC) have been employed as targets of interaction by the cationic polyamines spermidine ([H(3)N(CH(2))(3)NH(2)(CH(2))(4)NH(3)](3+)) and spermine ([(CH(2))(4)(NH(2)(CH(2))(3)NH(3))(2)](4+)). In solutions containing 60 mM DNA phosphate (approximately 20 mg DNA/ml) and either 1, 5 or 60 mM polyamine, only Raman bands associated with the phosphates exhibit large spectral changes, demonstrating that B-DNA phosphates are the primary targets of interaction. Phosphate perturbations, which are independent of base composition, are consistent with a model of non-specific cation binding in which delocalized polyamines diffuse along DNA while confined by the strong electrostatic potential gradient perpendicular to the helix axis. This finding provides experimental support for models in which polyamine-induced DNA condensation is driven by non-specific electrostatic binding. The Raman spectra also demonstrate that major groove sites (guanine N7 and thymine C5H(3)) are less affected than phosphates by polyamine-DNA interactions. Modest dependence of polyamine binding on genome base composition suggests that sequence context plays only a secondary role in recognition. Importantly, the results demonstrate that polyamine binding has a negligible effect on the native B-form secondary structure. The capability of spermidine or spermine to bind and condense genomic B-DNA without disrupting the native structure must be taken into account when considering DNA organization within bacterial nucleoids or cell nuclei.
Organic transistors on fiber: a first step towards electronic textiles (2004)

For the first time, we demonstrate flexible transistors formed directly on fibers. This represents a significant step towards the realization of electronics textiles. Fiber transistors exhibit mobilities of >10/sup -2/ cm/sup 2//V-s measured at 20 V V/sub DD/. The entire transistor is fabricated without resorting to conventional lithography techniques. Patterning is achieved via shadowing from overwoven fibers. The process is compatible with textile manufacturing, and is therefore a promising technology for scalable e-textile fabrication.
Insulin-Like Growth Factor I Stimulates the Synthesis and Release of Prolactin from Human Decidual Cells* (1988)

Recent studies suggest a role for insulin-like growth factor I (IGF-I) in the regulation of hormone release from placental, gonadal, and pituitary tissues. To examine whether IGF-I may also regulate the release of PRL from human decidual tissue, we have investigated the effect of recombinant human IGF-I on PRL release from monolayer cultures of human decidual cells exposed to IGF-I for up to 4 days. IGF-I (10-1000 ng/ml) stimulated a sustained dose-dependent increase in PRL release (half-maximal concentration, 25 ng/ml) beginning 48 h after initial exposure, but had no effect on the intracellular PRL content. The amounts of PRL released from maximally stimulated cultures on days 3 and 4 were 168 +/- 3% (mean +/- SEM) and 258 +/- 8% of control values, respectively. IGF-I-mediated effects were inhibited by cycloheximide (3.6 microM), suggesting that the increase in PRL was the result of newly synthesized hormone. The increase in PRL release was not due to a generalized effect on protein release, since IGF-I had no effect on the release of trichloroacetic acid-precipitable [35S]methionyl proteins. Radioligand competition studies indicate that the biological actions of IGF-I are mediated through interaction with the IGF-I receptor. Binding of radiolabeled IGF-I to decidual cells in suspension was specific, saturable, and displacable by unlabeled IGF-I, with a potency nearly 10 times greater than that of insulin. Furthermore, exposure of decidual cells to a monoclonal antibody to the IGF-I receptor (alpha-IR3) completely inhibited both IGF-I-mediated PRL release and specific binding of [125I]IGF-I to decidual cells. Since the actions of IGF-I occurred at physiological concentrations, these findings strongly support a role for IGF-I in the regulation of PRL secretion by human decidua.
Fully automated segmentation and tracking of the intima media thickness in ultrasound video sequences of the common carotid artery (2012)

The robust identification and measurement of the intima media thickness (IMT) has a high clinical relevance because it represents one of the most precise predictors used in the assessment of potential future cardiovascular events. To facilitate the analysis of arterial wall thickening in serial clinical investigations, in this paper we have developed a novel fully automatic algorithm for the segmentation, measurement, and tracking of the intima media complex (IMC) in B-mode ultrasound video sequences. The proposed algorithm entails a two-stage image analysis process that initially addresses the segmentation of the IMC in the first frame of the ultrasound video sequence using a model-based approach; in the second step, a novel customized tracking procedure is applied to robustly detect the IMC in the subsequent frames. For the video tracking procedure, we introduce a spatially coherent algorithm called adaptive normalized correlation that prevents the tracking process from converging to wrong arterial interfaces. This represents the main contribution of this paper and was developed to deal with inconsistencies in the appearance of the IMC over the cardiac cycle. The quantitative evaluation has been carried out on 40 ultrasound video sequences of the common carotid artery (CCA) by comparing the results returned by the developed algorithm with respect to ground truth data that has been manually annotated by clinical experts. The measured IMT(mean) ± standard deviation recorded by the proposed algorithm is 0.60 mm ± 0.10, with a mean coefficient of variation (CV) of 2.05%, whereas the corresponding result obtained for the manually annotated ground truth data is 0.60 mm ± 0.11 with a mean CV equal to 5.60%. The numerical results reported in this paper indicate that the proposed algorithm is able to correctly segment and track the IMC in ultrasound CCA video sequences, and we were encouraged by the stability of our technique when applied to data captured under different imaging conditions. Future clinical studies will focus on the evaluation of patients that are affected by advanced cardiovascular conditions such as focal thickening and arterial plaques.
Recurrent renal disease after renal transplantation (1994)

Recurrent disease does not lead to the loss of large numbers of allografted kidneys, but it is a source of serious concern in recipients with type I hyperoxaluria and focal segmental glomerulosclerosis. In patients with a number of other causes of renal failure, it may affect the use of living related donors. Recent topics for debate include the failure of cyclosporine to modify the incidence of recurrent disease, the realization that IgA nephropathy may in the long term lead to graft destruction, the fact that membranous nephropathy may recur in a quarter of the cases, and the knowledge that a nephrotic syndrome may reappear after transplantation for the Finnish congenital nephrotic syndrome.
The Toyota Way (2003)

1. ?Cuales son las claves del exito de Toyota? 2. ?Que papel juega la calidad como estrategia de negocios? 3. ?Cuales son las practicas gerenciales que aseguran el exito de esta compania? 4. ?Cuales son los factores a considerar para replicar el modelo Toyota en su compania? 5. ?Que cultura organizacional debe ser creada para alcanzar la excelencia? Algunas preguntas que responde El modelo Toyota Contenido