gebhart/patrepeval huggingface dataset:
Binding of Heparin/Heparan Sulfate to Fibroblast Growth Factor Receptor 4 (2001)

Fibroblast growth factors (FGFs) are heparin-binding polypeptides that affect the growth, differentiation, and migration of many cell types. FGFs signal by binding and activating cell surface FGF receptors (FGFRs) with intracellular tyrosine kinase domains. The signaling involves ligand-induced receptor dimerization and autophosphorylation, followed by downstream transfer of the signal. The sulfated glycosaminoglycans heparin and heparan sulfate bind both FGFs and FGFRs and enhance FGF signaling by mediating complex formation between the growth factor and receptor components. Whereas the heparin/heparan sulfate structures involved in FGF binding have been studied in some detail, little information has been available on saccharide structures mediating binding to FGFRs. We have performed structural characterization of heparin/heparan sulfate oligosaccharides with affinity toward FGFR4. The binding of heparin oligosaccharides to FGFR4 increased with increasing fragment length, the minimal binding domains being contained within eight monosaccharide units. The FGFR4-binding saccharide domains contained both 2-O-sulfated iduronic acid and 6-O-sulfated N-sulfoglucosamine residues, as shown by experiments with selectively desulfated heparin, compositional disaccharide analysis, and a novel exoenzyme-based sequence analysis of heparan sulfate oligosaccharides. Structurally distinct heparan sulfate octasaccharides differed in binding to FGFR4. Sequence analysis suggested that the affinity of the interaction depended on the number of 6-O-sulfate groups but not on their precise location.
New P,N-Ferrocenyl Ligands for the Asymmetric Ir-Catalyzed Hydrogenation of Imines (2007)

The Ir-catalyzed enantioselective hydrogenation of various N-(3,5-dimethyl-4-methoxy)phenylimines was performed under mild conditions in the presence of new P,N-ferrocenyl iridium complexes leading to (R)-N-(3,5-dimethyl-4-methoxy)phenylamines in high yields and enantioselectivities (up to 99%). These chiral aryl amines can be readily deprotected using Ce(NH4)2(NO3)6.
Array of Superconducting Quantum Interference Devices with Multiturn Input Coil (2004)

Arrays of dc-superconducting quantum interference devices (dc-SQUIDs) were investigated, in which each dc-SQUID element has a multiturn input coil. The dependence of flux noise on the number of turns of the input coil was studied for current amplifiers. SQUID arrays were fabricated by a Nb/AlO x /Nb Josephson tunnel junction fabrication process. Results show that the flux noise of the SQUID array amplifier does not depend on the turn number of the input coil. A SQUID array amplifier consisting of 128 dc-SQUID elements was fabricated, in which each element had a 7-turn input coil and a mutual inductance between the input coil and the SQUID loop of 460 pH. This amplifier showed an ultrahigh current resolution of 1 pA/Hz 0.5 and a maximum input current of 11 µA for signals of 50 kHz, which is sufficient bandwidth for X-ray detection applications. These values correspond to a large dynamic range of 87 dB. The flux-voltage characteristics of this SQUID array, however, showed asymmetric behavior, which originated from electronic resonance in stray capacitance and the mutual inductance between the SQUID loop and the multiturn input coil.
Lipoteichoic Acids, Phosphate-Containing Polymers in the Envelope of Gram-Positive Bacteria (2014)

Lipoteichoic acids (LTA) are polymers of alternating units of a polyhydroxy alkane, including glycerol and ribitol, and phosphoric acid, joined to form phosphodiester units that are found in the envelope of Gram-positive bacteria. Here we review four different types of LTA that can be distinguished on the basis of their chemical structure and describe recent advances in the biosynthesis pathway for type I LTA, d-alanylated polyglycerol-phosphate linked to di-glucosyl-diacylglycerol. The physiological functions of type I LTA are discussed in the context of inhibitors that block their synthesis and of mutants with discrete synthesis defects. Research on LTA structure and function represents a large frontier that has been investigated in only few Gram-positive bacteria.
[Pulmo cardialis: effect of inhaled bronchodilators on airway resistance of acute left ventricular dysfunction]. (1990)

Disturbance of left ventricular function leads to an impairment of ventilation: airway resistance increases, while pulmonary compliance is reduced. We therefore studied the effect of inhalable bronchodilators (Fenoterol, Ipratropium bromide) on oscillatory airway resistance in 16 patients with an acute left heart failure. The results show that the resistance can be significantly reduced to normal values by the bronchodilators. Fenoterol has the greatest spasmolytic potency, but Ipratropium bromide is also effective. Recompensation of left heart function alone does not lead to comparable acute effects on airway resistance. The possibility of immediate improvement of ventilation through the use of inhalable bronchodilators should therefore be considered in the treatment of acute left heart failure.
Electrokinetic high pressure hydraulic system (2023)

A compact high pressure hydraulic pump having no moving mechanical parts for converting electric potential to hydraulic force. The electrokinetic pump, which can generate hydraulic pressures greater than 2500 psi, can be employed to compress a fluid, either liquid or gas, and manipulate fluid flow. The pump is particularly useful for capillary-base systems. By combining the electrokinetic pump with a housing having chambers separated by a flexible member, fluid flow, including high pressure fluids, is controlled by the application of an electric potential, that can vary with time.
A multicentre, randomized, double‐masked, parallel group, vehicle‐controlled phase IIb study to evaluate the safety and efficacy of 1% and 3% topical minocycline gel in patients with papulopustular rosacea (2020)

Minocycline topical gel appears to be safe and tolerable at concentrations of 1% and 3%, and both concentrations significantly decreased inflammatory lesion counts, with a significantly larger proportion of patients achieving IGA success at week 12 in the minocycline 3% arm. These findings support further evaluation of minocycline gel for treating inflammatory lesions associated with papulopustular rosacea. Linked Comment: Hampton. Br J Dermatol 2020; 183:412-413.
Chimeric antigen receptors and bispecific antibodies to retarget T cells in pediatric oncology (2015)

Cancer immunotherapy using antigen‐specific T cells has broad therapeutic potential. Chimeric antigen receptors and bispecific antibodies can redirect T cells to kill tumors without human leukocyte antigens (HLA) restriction. Key determinants of clinical potential include the choice of target antigen, antibody specificity, antibody affinity, tumor accessibility, T cell persistence, and tumor immune evasion. For pediatric cancers, additional constraints include their propensity for bulky metastatic disease and the concern for late toxicities from treatment. Nonetheless, the recent preclinical and clinical developments of these T cell based therapies are highly encouraging. Pediatr Blood Cancer 2015;62:1326–1336. © 2015 Wiley Periodicals, Inc.
Study of New Liquid Crystal Materials (II): Synthesis and Mesomorphic Properties of Alkoxymethylene Substituted Phenyl Cyclohexanecarboxylates (1984)

Abstract The properties of alkoxymethylene-substituted-phenyl alkylcyclohexanecarboxylates are described. Such phenyl cyclohexanecarboxylates exhibit either a monotropic or an enantiotropic nematic phase. Their clearing points were lower than those of alkoxy-substituted-phenyl alkylcyclohexanecarboxylates, an effect considered to be due to the flexibility of the alkoxymethylene groups.
Acute renal failure with selective medullary injury in the rat. (1988)

Since human acute renal failure (ARF) is frequently the result of multiple rather than single insults, we used a combination of treatments to induce ARF in rats. Uninephrectomized, salt-depleted rats injected with indomethacin developed ARF after administration of radiocontrast. After 24 h, the plasma creatine rose from 103 +/- 3 to 211 +/- 22 mumol/liter (mean +/- SE) and the creatinine clearance dropped from 0.7 +/- 0.1 to 0.2 +/- 0.04 ml/min (P less than 0.001). Severe injury was confined to the outer medulla and comprised necrosis of medullary thick ascending limbs (mTALs), tubular collapse, and casts. Other nephron segments were free of damage except for the proximal convoluted tubules which showed vacuole formation originating from lateral limiting membranes that resembled changes reported in human contrast nephropathy. Cell damage to mTALs included mitochondrial swelling, nuclear pyknosis, and cytoplasmic disruption with superimposed calcification; these changes were most severe in the deepest areas of the outer medulla, away from vasa recta in zones remote from oxygen supply. The fraction of mTALs with severe damage was 30 +/- 7% (range 2-68) and the extent of injury was correlated with a rise in plasma creatinine (r = 0.8, P less than 0.001). Thus, the nature of mTAL injury was similar to the selective lesions observed in isolated kidneys perfused with cell-free medium and was shown to derive from an imbalance between high oxygen demand by actively transporting mTALs and the meager oxygen supply to the renal medulla. Combined multiple renal insults in the rat produce ARF that resembles the clinical syndrome of contrast nephropathy and is characterized by selective mTAL injury conditioned by medullary hypoxia.
Detection of partial discharge in power transformers using Rogowski coil and multiresolution analysis (2009)

Partial discharge detection in power transformers is discussed using a new approach that exploit the broad band of the Rogowski coils and the potential of two signal processing tools: discrete wavelet transform and empirical mode decomposition. Detecting and analyzing incipient activities of partial discharge can provide useful information to diagnostics and prognostics about transformer insulation. So, partial discharge signals embedded in the electric current at ground conductor are measured using the Rogowski coil. These signals are submitted to noise suppression and the partial discharges waveforms are extracted through different ways: using discrete wavelet transform and using empirical mode decomposition. These two methods are compared and their advantages discussed.
Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology (2018)

It is critical to determine the mutational status in cancer before administration and treatment of specific molecular targeted drugs for cancer patients. In the clinical setting, formalin-fixed paraffin-embedded (FFPE) tissues are widely used for genetic testing. However, FFPE DNA is generally damaged and fragmented during the fixation process with formalin. Therefore, FFPE DNA is sometimes not adequate for genetic testing because of low quality and quantity of DNA. Here we present a method of touch imprint cytology (TIC) to obtain genomic DNA from cancer cells, which can be observed under a microscope. Cell morphology and cancer cell numbers can be evaluated using TIC specimens. Furthermore, the extraction of genomic DNA from TIC samples can be completed within two days. The total amount and quality of TIC DNA obtained using this method was higher than that of FFPE DNA. This rapid and simple method allows researchers to obtain high-quality DNA for genetic testing (e.g., next generation sequencing analysis, digital PCR, and quantitative real time PCR) and to shorten the turnaround time for reporting results.
Electronic polarization-division demultiplexing based on digital signal processing in intensity-modulation direct-detection optical communication systems (2014)

We propose a novel configuration of optical receivers for intensity-modulation direct-detection (IM · DD) systems, which can cope with dual-polarization (DP) optical signals electrically. Using a Stokes analyzer and a newly-developed digital signal-processing (DSP) algorithm, we can achieve polarization tracking and demultiplexing in the digital domain after direct detection. Simulation results show that the power penalty stemming from digital polarization manipulations is negligibly small.
Maternal anxiety following newborn hearing screening: the moderating role of knowledge (2006)

Some issues and activities in cancer screening in Korea are briefly described, in particular those in stomach, breast and colorectal screening. There is randomized trial evidence for the efficacy of screening for breast cancer and colorectal neoplasia. Stomach cancer screening is as yet unproven, but the disease is very common in Korea and one of the leading causes of death. There are major related issues to be addressed by the country in the near future. These include improving uptake and coverage rates, quality control and evaluation. Colorectal cancer will be a major concern as its incidence and mortality rates have been increasing rapidly in recent years.
[Suppressive effects of antioxidant DA-9601 on hepatic fibrosis in rats]. (2002)

DA-9601 effectively protected rat liver tissues against the DMN-induced hepatic fibrosis. Antioxidant could be considered as a supplementary therapeutic for alleviating the hepatic fibrosis.
Solid dispersions, Part II: new strategies in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs (2011)

Many problems in this field still need to be solved, mainly the use of toxic solvents, and for this reason the use of innovative new procedures and materials will increase over the coming years. Melt mixing remains extremely promising for the preparation of SDs and will probably become the most used method in the future for the preparation of solid drug dispersions.
[Value of testing the abdominal leak point pressure in the differential diagnosis of urinary stress incontinence]. (2003)

In stress incontinent patients without urethral hypermotility an abdominal leak point pressure of less than 40 H2O cm perfectly reflects weakness of the urethral sphincter. Based on these data we suggest that the invasive urethral pressure profile test can be avoided in appr. 20% of stress incontinence cases by weakness of the sphincter.
Structure of (rGGCGAGCC)2 in solution from NMR and restrained molecular dynamics (1993)

The duplex (rGGCGAGCC)2 contains tandem G x A mismatches--a common motif in the secondary structures of biological RNAs. The three-dimensional structure of (rGGCGAGCC)2 was derived using molecular dynamics and energy minimization with NMR-derived restraints for 78 interproton distances (per strand), 18 hydrogen bonds for the six Watson-Crick G x C pairs, and 26 dihedral angles (per strand). The G x A mismatch structures are similar to those observed in a DNA duplex [Li, Y., Zon, G., & Wilson, W. D. (1991) Proc. Natl. Acad. Sci. U.S.A. 80, 26-30] and an RNA hairpin [Heus, H. A., & Pardi, A. (1991) Science 253, 191-193], with hydrogen bonds from guanine 2-amino and N3 to adenine N7 and 6-amino, respectively. The other G 2-amino and A 6-amino protons are within hydrogen-bonding distance of a phosphate oxygen and 2'-oxygen, respectively. Strong interstrand A-A and G-G stacking is observed between the G x A mismatches. This contrasts with the poor stacking observed between the G x A mismatches and closing G x C base pairs. The stems are basically A-form with all bases in the anti conformation and all nonterminal sugars in the C3'-endo conformation. The structure rationalizes previous thermodynamic, circular dichroism, and imino proton NMR results and suggests tandem G x A mismatches in RNA may provide a contact site for tertiary interactions.
Experimentally validated Raman Monte Carlo simulation for a cuboid object to obtain Raman spectroscopic signatures for hidden material (2015)

In conventional Raman spectroscopic measurements of liquids or surfaces the preferred geometry for detection of the Raman signal is the backscattering (or reflection) mode. For non‐transparent layered materials, sub‐surface Raman signals have been retrieved using spatially offset Raman spectroscopy (SORS), usually with light collection in the same plane as the point of excitation. However, as a result of multiple scattering in a turbid medium, Raman photons will be emitted in all directions. In this study, Monte Carlo simulations for a three‐dimensional layered sample with finite geometry have been performed to confirm the detectability of Raman signals at all angles and at all sides of the object. We considered a non‐transparent cuboid container (high density polyethylene) with explosive material (ammonium nitrate) inside. The simulation results were validated with experimental Raman intensities. Monte Carlo simulation results reveal that the ratio of sub‐surface to surface signals improves at geometries other than backscattering. In addition, we demonstrate through simulations the effects of the absorption and scattering coefficients of the layers, and that of the diameter of the excitation beam. The advantage of collecting light from all possible 4π angles, over other collection modes, is that this technique is not geometry specific and molecular identification of layers underneath non‐transparent surfaces can be obtained with minimal interference from the surface layer. To what extent all sides of the object will contribute to the total signal will depend on the absorption and scattering coefficients and the physical dimensions. Copyright © 2015 John Wiley & Sons, Ltd.
Concealment of damaged block transform coded images using projections onto convex sets (1995)

An algorithm for lost signal restoration in block-based still image and video sequence coding is presented. Problems arising from imperfect transmission of block-coded images result in lost blocks. The resulting image is flawed by the absence of square pixel regions that are notably perceived by human vision, even in real-time video sequences. Error concealment is aimed at masking the effect of missing blocks by use of temporal or spatial interpolation to create a subjectively acceptable approximation to the true error-free image. This paper presents a spatial interpolation algorithm that addresses concealment of lost image blocks using only intra-frame information. It attempts to utilize spatially correlated edge information from a large local neighborhood of surrounding pixels to restore missing blocks. The algorithm is a Gerchberg (1974) type spatial domain/spectral domain constraint-satisfying iterative process, and may be viewed as an alternating projections onto convex sets method.
79‐2: An Image Quality Evaluation Method of Near‐eye Display (2016)

An image quality evaluation method is proposed according to Modulation Transfer Function, and considers eyes imaging modality. It can easily, quickly and economically evaluate the image quality of Near‐eye Display and also provides a good reference for the design of Near‐eye Display.
Signals and linear systems (1973)

Linear Systems. Discrete-Time Systems. Continuous-Time Systems. The Z-Transform. Fourier Analysis. The Laplace Transform. An Introduction to the Design of Digital Filters. Suggested Readings. Appendices. Glossary. Index.
Enhancing the Distributed Link Service for multimedia and collaboration (2002)

Open hypermedia offers a powerful approach to working with distributed multimedia information. Carr et al. (1995) presented the Distributed Link Service (DLS), a design for open hypermedia on the Internet using the WWW infrastructure. In this paper, we report on work in progress on three extensions of the DLS to provide a more complete linking infrastructure: an agent for on-the-fly link insertion for text documents, new techniques for application of links to multimedia streams, and agents for link processing and management.
Double‐stage phase‐diversity (DSPD) scheme for coherent optical fiber communications—optical circuit imbalance and its compensation (1991)

Abstract The double‐stage phase‐diversity (DSPD) scheme we have proposed features a phase‐diversity‐type optical homodyne detection followed by a phase‐diversity‐type electrical frequency up‐conversion, giving a heterodyne‐like intermediate frequency (IF) signal. It has the advantages of both heterodyning and homodyning. In this paper, we first calculate the sensitivity penalty due to the optical circuit (hybrid) imbalance in a DSPD receiver. It is shown that the penalty is as small as that in a conventional phase‐diversity receiver and that the optical circuit requirement is not severe. The DSPD experiment with an adjustable imbalance is then performed to confirm the theory; experimental results are in good agreement with the theory. Finally, the possibility of compensation of the optical imbalance at the electronic stage of the receiver is shown.
Driving Control Using Emotion Analysis Via EEG (2018)

Driving is a very taxing job as the visual, sensory and motor inputs work in harmony to make driving a successful experience. However, when the harmony is distorted, as in the cases when the driver is frustrated, anxious, the negative mindset can be dangerous as it can lead to potential accidents. Analyzing the emotions of the driver and striving to control them therefore becomes important. The work in this paper focuses on enhancing the current driving system of cars to help reduce the accident rate. It uses analysis of driver emotions via the data obtained from EEG (Electroencephalography) waves and the valence-arousal models for emotion classification. Additionally, the control of emotions is obtained via the concept of music therapy. The proposed approach uses the music system in the car to automatically respond to changes in the emotional state of the driver. The emotion detection would be relatively real time thus efficiently soothing the driver. Moreover, the automatic adjustment of music in consonance with the mood would reduce the manual interfacing of the knobs in the car, thus saving distraction and reducing the chances of accidents.
Towards a Unified Secure Cloud Service Development and Deployment Life-Cycle (2016)

Designing and developing cloud services is a challenging task that includes requirements engineering, secure service deployment, maintenance, assurance that proper actions have been taken to support security and, in addition, considering legal aspects. This is unfortunately not possible by taking current methods and techniques into consideration. Therefore, we require a systematic and comprehensive approach for building such services that starts the integration of security concerns from early stages of design and development, and continuous to refines and integrate them in the deployment phase. In this paper we therefore propose a solution that integrates security requirements engineering and continuous refinement in a comprehensive security development and deployment life-cycle for cloud services and applications. Our approach is focused on iterative refinement of the security-based requirements during both software engineering (development phase) and software maintenance (deployment phase).