gebhart/patrepeval huggingface dataset:
Phase 1b study of GS-3583, a novel FLT3 agonist Fc fusion protein, in patients with advanced solid tumors. (2022)

2566 Background: We have previously shown that systemic administration of GS-3583, a Fms-like tyrosine kinase 3 (FLT3) agonist Fc fusion protein leads to expansion of conventional dendritic cells (cDC), both subtype 1 (cDC1) and subtype 2 (cDC2), in the periphery of healthy volunteers (Rajakumaraswamy N, et al. J Clin Oncol. 2021;39[suppl_15]:2559.). This mechanism may increase cDC in the tumor microenvironment and promote T cell mediated antitumor activity in patients with solid tumors. Methods: This ongoing, Phase 1b, open label study is investigating the safety, tolerability, immunogenicity, pharmacokinetics, and pharmacodynamics of escalating multiple doses of GS-3583 monotherapy in adult patients with advanced solid tumors using a standard 3 + 3 design. GS-3583 was administered intravenously on Days 1 and 15 of Cycle 1 and on Day 1 of each subsequent 28-day cycle for up to 52 weeks or until progressive disease or unacceptable toxicity. Dose-limiting toxicity (DLT) was evaluated during the first 28 days of GS-3583 therapy at each dose level. Results: At the time of the Dec 3, 2021 data cut-off, 9 patients have enrolled in 3 dose escalation cohorts. Median (range) age was 71 (44-79); 4 (44%) patients were male. Tumor types were pancreatic (n=3), ovarian (n=4), and rectal (n=2). To date, no DLTs or discontinuation due to adverse events (AE) have been observed. Three patients had Grade ≥3 AEs which were also recorded as serious AEs, none of which were considered related to GS-3583. Dose dependent increase in GS-3583 exposure was observed in the evaluated dose range 2 to 12 mg with target-mediated drug disposition appearing to be saturated at doses above Dose Level 2. GS-3583 accumulation was observed at higher dose levels. GS-3583 treatment resulted in expansions of cDC1 and cDC2 at all 3 doses (Table); a dose-dependent trend in the magnitude and the durability of cDC expansion was observed. At the highest dose evaluated, GS-3583 produced ≥100-fold expansion of both cDC1 and cDC2 at multiple time points. Dose escalation on the study is still ongoing. Conclusions: GS-3583 was safe and well tolerated and induced dose-dependent expansion of cDCs in the periphery in patients with advanced solid tumors up to doses of 12 mg. These findings support further dose escalation and clinical development of GS-3583 in combination with agents that would stimulate the expanded cDCs to produce anti-tumor responses. Clinical trial information: NCT04747470. [Table: see text]
Flexible Multilayer Sparse Approximations of Matrices and Applications (2016)

The computational cost of many signal processing and machine learning techniques is often dominated by the cost of applying certain linear operators to high-dimensional vectors. This paper introduces an algorithm aimed at reducing the complexity of applying linear operators in high dimension by approximately factorizing the corresponding matrix into few sparse factors. The approach relies on recent advances in nonconvex optimization. It is first explained and analyzed in details and then demonstrated experimentally on various problems including dictionary learning for image denoising and the approximation of large matrices arising in inverse problems.
Performance analysis of a CDMA/FDMA cellular communication system with cell splitting (2002)

A new cellular communication system based upon direct sequence spread spectrum code division multiple access (DS-SS-CDMA) and frequency division multiple access (FDMA) along with a unique cell structure is proposed. Performance analysis of the proposed system under Rayleigh multipath fading and log normal shadowing channels showed that this model increased the forward link capacity by a factor of approximately seven to ten over the standard CDMA cellular system. Also, under ideal power control and similar channel conditions, the reverse link capacity moderately increased over the standard CDMA implementation. The proposed system demonstrated that it is possible to increase the cell capacity without deploying additional cells by applying proper FDMA frequency reuse to minimize interference.
Increased Bleomycin-Induced Skin Fibrosis in Mice Lacking the Th1-Specific Transcription Factor T-bet (2006)

Fibrosis, the pathological hallmark of scleroderma and related conditions, is due to sustained activation of tissue fibroblasts. Accumulating evidence implicates cytokine networks in initiating, and propagating or terminating fibroblast activation, and the specific cytokine phenotype dictates evolution of the fibrotic response toward either resolution or scarring. In particular, cytokines that promote fibroblast proliferation and myofibroblast differentiation and extracellular matrix (ECM) accumulation functionally define a type 2 (Th2) immune response, whereas interferon-gamma, which suppresses diverse fibroblast activities, defines a type 1 (Th1) immune response. It remains unclear what role the balance between Th1 and Th2 cytokines plays in the pathogenesis of fibrosis. Here we used bleomycin-induced skin fibrosis as a murine model for human scleroderma in order to study the fibrotic response in mice lacking T-bet, a transcription factor that is essential for initiating Th1 lineage development of CD4+ T lymphocytes. Spleen cells from T-bet null (T-bet(-/-)) mice exhibited a typical Th2 cytokine profile ex vivo, with elevated production of interleukin-4 (IL-4), IL-5 and IL-13, and diminished production of interferon-gamma. Bleomycin-induced early mast cells and eosinophil accumulation, and eosinophil degranulation, in the lesional tissue were greater in T-bet(-/-) mice than in wild-type control mice. At a later time point, T-bet(-/-) mice developed significantly more extensive dermal and especially hypodermal fibrosis. Elevated TGF-beta expression and intracellular Smad activation were prominent in lesional skin. Infiltrating eosinophils appeared to be an important cellular source of TGF-beta. These results demonstrate that in mice lacking T-bet bleomycin induced exaggerated skin fibrosis, suggesting that T-bet has an important physiologic role in regulation of tissue repair by promoting Th1 immune responses that prevent excessive ECM accumulation.
Chemical sensor based on surface acoustic wave resonator using Langmuir-Blodgett film (1998)

A one-port surface acoustic wave (SAW) resonators incorporating Langmuir-Blodgett (LB) films has been investigated. SAW sensors are one potential applications of SAW devices. Most of the work reported on SAW sensor concerns delay lines. In this paper we characterize the mass loading effects of one-port resonators by depositing successive monolayers of LB films onto the surface. A 90 MHz SAW gas-phase sensor has been fabricated on an ST cut quartz substrate, and one-port resonator configurations have been used as the sensing element. Ultra thin monolayers of arachidic acid and arachidic acid ethyl ester have been deposited using the LB method. The resonant frequencies and the Q values have been measured as sensor response. Experimental results show that the Q values and the resonant frequencies of the one-port SAW resonator vary with film mass loading on the SAW device surface.
Bioluminescence in oceanology (1989)

For analytical purposes bioluminescence can be used in three main ways: 1. luminescence measurement of bioluminescent system components isolated in vitro; 2. determination of luminous organisms' reaction to the in vivo test-action; 3. measurement of bioluminescence in marine ecological systems. The majority of the reports of this Symposium are dealing with the first two topics. The aim of our presentation is to draw attention to the third one. The possibilities of bioluminescent analysis are wider than its traditional scheme of applications in the laboratory, when the emitting system is withdrawn from a native source and is placed in a cuvette of the light measuring device. The reverse scheme is also possible, i.e. the device can be introduced into light emitting system such as a marine biocenosis--the community of the sea inhabitants--where we obtain a highly sensitive and rapid means of gaining the information on the vital activity of marine ecosystems, i.e. their spatial structure, rhythms, man's influence upon them, etc. The present communication will consider the possibilities of this form of bioluminescent analysis.
Adaptive Optics in Astronomy (1994)

Optical observations by ground-based astronomers have long been limited by the distorting effects of the Earth's atmosphere. Primary mirrors have been polished to exquisite accuracy for telescopes with apertures as large as 10 meters, but at optical wavelengths these can deliver an angular resolution typically no better than that of a 25-cm telescope, as atmospheric turbulence deforms the image on a millisecond time scale. One (highly expensive) approach to overcome this problem has been to loft instruments such as the Hubble Space Telescope above the atmosphere. Another approach, pursued by instrument builders in the astronomy community and their counterparts in the military, has been to design electro-optical systems that measure and undo the effects of clear-air turbulence in real time. (See figure 1.) A number of such adaptive optic devices have already been built and operated on large ground-based telescopes, delivering near-diffraction-limited performance at infrared and visible wavelengths. With the first significant astronomical images beginning to appear from these adaptive optics systems (see the cover of this issue), the level of interest in this work is rising very rapidly in the astronomy community.
Endothelial Cell Co-culture Mediates Maturation of Human Embryonic Stem Cell to Pancreatic Insulin Producing Cells in a Directed Differentiation Approach (2012)

Embryonic stem cells (ESC) have two main characteristics: they can be indefinitely propagated in vitro in an undifferentiated state and they are pluripotent, thus having the potential to differentiate into multiple lineages. Such properties make ESCs extremely attractive for cell based therapy and regenerative treatment applications. However for its full potential to be realized the cells have to be differentiated into mature and functional phenotypes, which is a daunting task. A promising approach in inducing cellular differentiation is to closely mimic the path of organogenesis in the in vitro setting. Pancreatic development is known to occur in specific stages, starting with endoderm, which can develop into several organs, including liver and pancreas. Endoderm induction can be achieved by modulation of the nodal pathway through addition of Activin A in combination with several growth factors. Definitive endoderm cells then undergo pancreatic commitment by inhibition of sonic hedgehog inhibition, which can be achieved in vitro by addition of cyclopamine. Pancreatic maturation is mediated by several parallel events including inhibition of notch signaling; aggregation of pancreatic progenitors into 3-dimentional clusters; induction of vascularization; to name a few. By far the most successful in vitro maturation of ESC derived pancreatic progenitor cells have been achieved through inhibition of notch signaling by DAPT supplementation. Although successful, this results in low yield of the mature phenotype with reduced functionality. A less studied area is the effect of endothelial cell signaling in pancreatic maturation, which is increasingly being appreciated as an important contributing factor in in-vivo pancreatic islet maturation. The current study explores such effect of endothelial cell signaling in maturation of human ESC derived pancreatic progenitor cells into insulin producing islet-like cells. We report a multi-stage directed differentiation protocol where the human ESCs are first induced towards endoderm by Activin A along with inhibition of PI3K pathway. Pancreatic specification of endoderm cells is achieved by inhibition of sonic hedgehog signaling by Cyclopamine along with retinoid induction by addition of Retinoic Acid. The final stage of maturation is induced by endothelial cell signaling achieved by a co-culture configuration. While several endothelial cells have been tested in the co-culture, herein we present our data with rat heart microvascular endothelial Cells (RHMVEC), primarily for the ease of analysis.
Ocular hypertensive effect of menopause with and without systemic hypertension (1996)

Menopause significantly increases intraocular pressure. Mean intraocular pressure of hypertensive postmenopausal women was significantly (p<0.05) higher than that of normotensive postmenopausal women. Knowledge of the normal level of intraocular pressure during various stages of female sexual life may help glaucoma screeners.
Möbius bis and tris-spiroaromatic systems (2002)

We propose that a general class of bis and tris-spiro 7-membered ring systems with a common atom X, of which there are a number of examples characterised crystallographically, can in fact be considered as spiroaromatic molecules in which each ring exhibits some degree of Möbius 4n pi-electron aromaticity. The aromaticity is probed as a function of the spiro-atom using ab initio calculations of the NICS(0) values, which indicate that the Möbius-aromaticity increases as the spiro-atom is changed e.g. from Al to P, and from e.g. P to As.
Coagulopathy associated with extended-spectrum cephalosporins in patients with serious infections (1987)

Patients enrolled in two double-blind multicenter studies were evaluated for the development of hypoprothrombinemia during treatment with cephalosporins. Patients with pneumonia or peritonitis received ceftizoxime, cefotaxime, or moxalactam. The incidence of hypoprothrombinemia was greater in patients with peritonitis (12 of 49) than in those with pneumonia (5 of 96; P less than 0.05). Overall, moxalactam was associated with a higher incidence of hypoprothrombinemia (13 of 52) than either ceftizoxime (1 of 43; P less than 0.05) or cefotaxime (3 of 50; P less than 0.05), and moxalactam patients incurred the highest average increase in prothrombin time (3.7 s) as compared with either ceftizoxime (0.5 s; P less than 0.05) or cefotaxime (0.9 s; P less than 0.05) patients. The occurrence of hypoprothrombinemia in moxalactam patients with peritonitis was not related to dosage, duration of therapy, age, sex, race, or renal or hepatic function. The degree of ileus was, however, strongly related to the development of coagulopathy in moxalactam-treated patients only.
Curie temperatures of synthetic titanomagnetites in the Fe‐Ti‐O system: Effects of composition, crystal chemistry, and thermomagnetic methods (2006)

The present study is aimed at improving the calibration of the compositional dependence of the Curie temperature ( T C ) of titanomagnetite (Tmt) on the basis of temperature‐dependent magnetic susceptibility ( χ ‐ T ) curves measured on synthetic Tmts in the Fe‐Ti‐O system. In order to assess the possible influence of high‐temperature cation vacancies onto the T C values, we have synthesized two types of assemblages in subsolidus conditions at 1 bar, 1100°C and 1300°C, under controlled oxygen fugacity conditions. Tmts synthesized in equilibrium with ilmenite‐hematite ss (Ilm ss ) are expected to have the highest vacancy concentrations, those in equilibrium with wüstite (Wus) the lowest. The composition and homogeneity of the synthetic Tmts were carefully checked with a scanning electron microscope (SEM) and an electron microprobe (EMP). T C was determined from χ ‐ T curves using a kappabridge and, for comparison, from M s ‐ T curves measured with a variable field translation balance. Our data set shows systematically higher T C values for Tmt coexisting with Ilm ss than for Tmt coexisting with Wus. Most χ ‐ T curves are nonreversible, whereby the largest Δ T C (40 K) concern Tmt(+Ilm ss ) of intermediate compositions synthesized at 1300°C. Nonreversibility is interpreted as reflecting cation reordering in Tmt during the high‐temperature χ ‐ T measurements. T C values obtained from M s ‐ T curves are higher than those obtained from the χ ‐ T curves, whereby the difference regularly increases (up to 40 K) with increasing Ti content, up to X Usp = 0.6. Our new calibration curves are suitable to retrieve Tmt compositions in basalts that were rapidly cooled and not oxidized by deuteric or hydrothermal fluids.
Bulk sensitive hard x-ray photoemission electron microscopy (2014)

Hard x-ray photoelectron spectroscopy (HAXPES) has now matured into a well-established technique as a bulk sensitive probe of the electronic structure due to the larger escape depth of the highly energetic electrons. In order to enable HAXPES studies with high lateral resolution, we have set up a dedicated energy-filtered hard x-ray photoemission electron microscope (HAXPEEM) working with electron kinetic energies up to 10 keV. It is based on the NanoESCA design and also preserves the performance of the instrument in the low and medium energy range. In this way, spectromicroscopy can be performed from threshold to hard x-ray photoemission. The high potential of the HAXPEEM approach for the investigation of buried layers and structures has been shown already on a layered and structured SrTiO3 sample. Here, we present results of experiments with test structures to elaborate the imaging and spectroscopic performance of the instrument and show the capabilities of the method to image bulk properties. Additionally, we introduce a method to determine the effective attenuation length of photoelectrons in a direct photoemission experiment.
Direct current pulse train actuation to enhance droplet control in digital microfluidics (2012)

The effective operation of a digital microfluidic (DMF) device depends on its ability to actuate droplets. Pulse width modulation of actuating signals (DC pulse train actuation) is proposed as a practical digital implementation and enhanced droplet manipulation technique. Experimental and simulation results demonstrate the efficacy of droplet incremental displacement and velocity control by modulating the width of each actuation pulse. This will in turn enable the control of the non-linear droplet transport dynamics to minimize droplet position overshoot, deformation, and fragmentation. As a result, DCPT actuation offers unparalleled control over droplet position and speed in DMF devices.
Family centred care for the neonate -- the view from Wolverhampton. (2004)

The increased technology of neonatal intensive care has meant that babies born at increasingly lower gestational age are surviving to be discharged home. A family centred approach in neonatal care supports the move toward patient or parent empowerment, which is vital, if babies are to be fully integrated into the family unit. Nurses are essential to the success of this process as they have the most direct and prolonged contact with both family and their baby. Critical care areas such as Neonatal Units (NNU) can be adjusted to support a more family focused philosophy. In Wolverhampton Orems 'Self-Care Model' of self care has been adapted to the family as the self care unit and simple adjustments to the area such as Quiet Times supports families feeling of well being and control.
Some Aspects of the Structure, Immunochemistry, and Genetic Control of Yeast Mannans (1974)

Introduction The Structure of Yeast Mannan Immunochemistry of Yeast Mannans Genetic Control of Yeast-Mannan Structure Enzymes That Degrade Yeast Mannan Some Thoughts about Mannan Biosynthesis
A Sequence Learning Model with Recurrent Neural Networks for Taxi Demand Prediction (2017)

In this paper, we focus on an application of recurrent neural networks for learning a model that predicts taxi demand based on the requests in the past. A model that can learn time series data is necessary here since taxi requests in the future relate to the requests in the past. For instance, someone who requests a taxi to a movie theater, may also request a taxi to return home after few hours. We use Long Short Term Memory (LSTM), one of the best models for learning time series data. For training the network, we encode the historical taxi requests from the official New York City taxi trip dataset and add date, day of the week and time as impacting factors. Experimental results show that our approach outperforms the prediction heuristics based on feed-forward neural networks and naive statistic average.
Growth Rates in Pediatric Diagnostic Imaging and Sedation (2009)

Future workload for anesthesia providers administering general anesthesia and/or sedation for pediatric diagnostic imaging will depend on trends in the total number of scans performed. Workload may also be sensitive to factors that increase scan duration or alter the percentage of patients in the 3-5 yr age group. It may additionally depend on reimbursements from insurance companies.
Transit-time reduction in AlGaAs/GaAs HBTs utilizing velocity overshoot in the p-type collector region (1988)

The effect of electron-velocity overshoot in a p-type GaAs collector on the transit-time reduction of AlGaAs/GaAs HBTs (heterojunction bipolar transistors) is investigated. A cutoff frequency improvement of about 30% over the conventional n-type GaAs collector was obtained in p-type collector HBTs for the same collector depletion-layer width. A significant increase in electron velocity in the p-type GaAs collector layer was confirmed by a simple analysis.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A PC-DSP-based unified control system design for FACTS devices (2002)

This paper presents a practical implementation of a PC-DSP-based unified control system for FACTS. Based on C++ technology, the DOS-kernel-WINDOWS-outface PC system provides real-time monitoring, control, coordination, and protection to the two DSP-based slave subsystems. The PC also works as a testbench to provide online and offline analysis of FACTS devices. Tasks such as real-time data display, data recording and operation mode switching are easier to perform. The DSP-based data acquisition subsystem (DAS) implements real-time signal processing such as digital filtering, space phasor calculation, and system frequency measurement. Combined with its unique synchronous signal generator circuit, the DAS measures the system frequency within 0.01 Hz. The DSP-based PWM control signal generation subsystem (CSGS) is capable of generating the programmable switching signals with adjustable blanking time. Also with its embedded finite state machine (FSM) it can provide unique fault indication and protection for FACTS devices. The unified control system has been successfully used in a scaled UPFC at the University of Missouri-Rolla.
Context analysis by the gamma neural network (2002)

This paper presents a gammma neural network that learns temporal context through the adaptation of the depth of the maintained short-term memory. The capability of context learning by the gamma network is demonstrated in the domain of sleep staging.