gebhart/patrepeval huggingface dataset:
Lengthy virtual cathode as key to repetitive operation of relativistic magnetrons (2016)

We recently proposed replacing a physical cathode in a relativistic magnetron with diffraction output with a virtual cathode. An electron beam is injected into the relativistic magnetron from a cathode located external to the interaction space. The geometry of both the electron beam injector and the magnetron interaction space were optimized to produce a virtual cathode from which electron spoke formation originates. This paper discusses how the length of such a virtual cathode can be optimized.
Microfluidic sensor for dynamic surface tension measurement (2006)

A novel microfluidic sensor for measuring dynamic gas-liquid interfacial tension is reported. The device consists of a microfluidic chip with a microchannel network and an optical detection system. The sample is introduced into a main channel, while air is injected through a T-junction. Owing to the fixed flow rate ratio used for the sensor, surface tension is the only parameter determining bubble formation frequency, which can be measured by optical detection. Although the bubble is represented by a pulse in the output signal, the formation frequency is simply the frequency of the output signal. Measurements were carried out for aqueous solutions with different concentrations of the ionic surfactant cetyl trimethyl ammonium bromide. Surface tensions of these solutions were calibrated with a commercial tensiometer. The measurement results show a clear relationship between surface tension and formation frequency. The sensor can be used to identify the critical micelle concentration of the surfactant. The sensor potentially allows the use of a minute amount of sample compared with the relatively large amount required for existing commercial systems.
Piezoelectric polymer film transducers for communications (1985)

Electroacoustic transducers based on piezoelectric PVDF can be used as microphone, receiver, or tone ringer for electronic telephones. The output level of a curved polymer film sound generator was found to depend on material properties (elastic and piezoelectric constants) and film configuration. Transducer elements using double diaphragms operating in push-pull are simple in construction, light weight, and show improved voltage efficiency. Performance characteristics including output level, frequency response, and impedance will be given for microphones, receivers, and tone ringers.
Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling (2006)

Inhibition of angiotensin I-converting enzyme (ACE) has become an effective strategy in the treatment of hypertension and cardiovascular disease. Keto-ACE, a previously described C-domain selective ACE inhibitor, was used as the basis for the design, synthesis and molecular modelling of a series of novel ketomethylene derivatives for which ACE inhibition profiles and structural characterisation are reported. Ki determinations indicated that the introduction of a bulky aromatic tryptophan at the P2' position of keto-ACE significantly increased selectivity for the C-domain, while an aliphatic P2 Boc group conferred N-domain selectivity. These data were supported by the potential energies of the compounds docked with the C- and N-domains of ACE.
Silhouette-Based 3D Face Shape Recovery (2003)

Though realistic eulerian fluid simulation systems now provide believable movements, straightforward renderable surface representation, and affordable computation costs, they are still unable to deal with non-static objects in a realistic manner. Namely, objects can not have an influence on the fluid and be simultaneously affected by the fluid's motion. In this paper, a simulation scheme for fluids allowing automatic generation of physically plausible motions alongside realistic interactions with solids is proposed. The method relies mainly on the definition of a coupling force between the solids and the fluid, thus bridging the gap between commonly used eulerian fluid animation models and lagrangian solid ones. This new method thus improves existing fluid simulations, making them capable of generating new kinds of motions, such as a floating ball displaced by the wave created thanks to its own splash into the water.
Development of a Liquid-Fueled Dry Low Emissions Combustor for 300kW Class Recuperated Cycle Gas Turbine Engines (2005)

The authors have developed a liquid-fueled, low-emissions, and single can combustor for the RGT3R, Niigata’s 300 kW class industrial gas turbine engine, with the goal of satisfying the most stringent environmental requirements for distributed power generation systems in Japan. This paper describes these development efforts, which included non-reacting Computational Fluid Dynamics (CFD) analysis and component and engine tests. The emissions target is less than 24 ppm nitrogen oxides (NOx), 60 ppm carbon monoxide (CO) and 60 ppm unburned hydrocarbons (UHCs) at dry 15% O2 correction for kerosene, while operating above 50% load. A lean premixed, pre-vaporized, axially staged combustion concept is used to minimize emissions levels to the strictest emissions regulations in urban areas such as Tokyo, Chiba, Saitama, Yokohama, and Osaka. This combustion system involves two pilot burners and two main mixture injection tubes that are extending into the combustion chamber to inject lean to ultra-lean premixed mixtures into the hot burned gas from pilot burners. Counter rotational swirl vanes are provided to pilot burners and main mixture injection tubes to prevent flashback into the premixing tubes. The RGT3R gas turbine engine operates smoothly with the developed DLE combustion system from idle to full load without combustion-driven pressure oscillations. A two-stage fuel control system employs liquid fuel supply for the pilot and main atomizers. As this paper describes, the emissions data from this engine meet the emissions goals.
Minimizing the search space in sniper localization using sensor configuration (2010)

In this paper an algorithm for sniper localization using disparate single microphone sensors that uses only the time difference of arrival (TDOA) between muzzle blast and shock wave is presented. Just as in any algorithm that looks for optimal solution this algorithm also faces the local minima (possible sniper locations) problem. In order to find the global or near global solution one has to perform search over a large area. In order to reduce the computational burden, the search space needs to be small. In this paper, an upper and lower bound on the range for the search space are estimated using the sensor configuration. Based on this, the area around the bullets path is searched with the bounds on range to determine the exact or near global solution for the sniper location. The results of sniper localization algorithm applied to real data collected in a field test will be presented.
Observation of quantum wire formation at intersecting quantum wells (1992)

We report the first observation of a quantum bound state formed at the junction of two intersecting quantum wells in the shape of a T. The atomically precise T junctions are fabricated by a novel cleaved edge overgrowth process in the AlGaAs/GaAs system. The identification of bound states with energies in excess of 20 meV is made by optical emission and absorption spectroscopy. Such quantum wire states are caused by the unique confinement of the lowest state wave function to the region of the T junction.
Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) to β-lactam antibiotics (2013)

The continuous emergence of resistant bacteria has become a major worldwide health threat. The current development of new antibacterials has lagged far behind. To discover reagents to fight against resistant bacteria, we initiated a chemical approach by synthesizing and screening a small molecule library, reminiscent of the polycyclic indole alkaloids. Indole alkaloids are a class of structurally diverse natural products, many of which were isolated from plants that have been used as traditional medicine for millennia. Specifically, we adapted an evolutionarily conserved biosynthetic strategy and developed a concise and unified diversity synthesis pathway. Using this pathway, we synthesized 120 polycyclic indolines that contain 26 distinct skeletons and a wide variety of functional groups. A tricyclic indoline, Of1, was discovered to selectively potentiate the activity of β-lactam antibiotics in multidrug-resistant methicillin-resistant Staphylococcus aureus (MRSA), but not in methicillin-sensitive S. aureus. In addition, we found that Of1 itself does not have antiproliferative activity but can resensitize several MRSA strains to the β-lactam antibiotics that are widely used in the clinic, such as an extended-spectrum β-lactam antibiotic amoxicillin/clavulanic acid and a first-generation cephalosporin cefazolin. These data suggest that Of1 is a unique selective resistance-modifying agent for β-lactam antibiotics, and it may be further developed to fight against resistant bacteria in the clinic.
Pulsed dye laser treatment of benign cutaneous pigmented lesions (1992)

Superficial benign cutaneous pigmented lesions that commonly present to the dermatologists and plastic surgeons have been treated by many conventional modalities such as dermabrasion, depigmenting creams as well as several types of lasers. Many of these treatment modalities lack specificity of injury, which has meant that normally pigmented and even non-pigment containing structures such as collagen as well as the hyperpigmented lesion itself have all been indiscriminately destroyed. This has resulted variously in hypopigmentation, hyperpigmentation, in addition to scar formation in some cases. A coaxial 504 nm laser with a pulse duration of 300 nsec was used to treat fifty two patients with superficial benign cutaneous pigmented lesions. Although the number of treatments required to clear the lesion varied according to the type of lesions being treated, on average, between 2 and 4 treatments were required to completely eradicate the superficial benign cutaneous pigmented lesions using 504 nm pulsed dye laser. The skin at the site successfully cleared of the pigmented lesion remained normal in skin color, texture, markings, and mobility.
Discrimination of Enterohemorrhagic Escherichia coli (EHEC) from Non-EHEC Strains Based on Detection of Various Combinations of Type III Effector Genes (2013)

Enterohemorrhagic Escherichia coli (EHEC) strains comprise a subgroup of Shiga-toxin (Stx)-producing E. coli (STEC) and are characterized by a few serotypes. Among these, seven priority STEC serotypes (O26:H11, O45:H2, O103:H2, O111:H8, O121:H19, O145:H28, and O157:H7) are most frequently implicated in severe clinical illness worldwide. Currently, standard methods using stx, eae, and O-serogroup-specific gene sequences for detecting the top 7 EHEC serotypes bear the disadvantage that these genes can be found in non-EHEC strains as well. Here, we explored the suitability of ureD, espV, espK, espN, Z2098, and espM1 genes and combinations thereof as candidates for a more targeted EHEC screening assay. For a very large panel of E. coli strains (n = 1,100), which comprised EHEC (n = 340), enteropathogenic E. coli (EPEC) (n = 392), STEC (n = 193), and apathogenic strains (n = 175), we showed that these genetic markers were more prevalent in EHEC (67.1% to 92.4%) than in EPEC (13.3% to 45.2%), STEC (0.5% to 3.6%), and apathogenic E. coli strains (0 to 2.9%). It is noteworthy that 38.5% of the EPEC strains that tested positive for at least one of these genetic markers belonged to the top 7 EHEC serotypes, suggesting that such isolates might be Stx-negative derivatives of EHEC. The associations of espK with either espV, ureD, or Z2098 were the best combinations for more specific and sensitive detection of the top 7 EHEC strains, allowing detection of 99.3% to 100% of these strains. In addition, detection of 93.7% of the EHEC strains belonging to other serotypes than the top 7 offers a possibility for identifying new emerging EHEC strains.
Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy (2019)

EphA4 is a receptor of the Eph-ephrin system, which plays an important role in axon guidance during development. Previously, we identified EphA4 as a genetic modifier of amyotrophic lateral sclerosis (ALS) in both zebrafish and rodent models, via modulation of the intrinsic vulnerability, and re-sprouting capacity of motor neurons. Moreover, loss of EphA4 rescued the motor axon phenotype in a zebrafish model of spinal muscular atrophy (SMA). Similar to ALS, SMA is a neurodegenerative disorder affecting spinal motor neurons resulting in neuromuscular junction (NMJ) denervation, muscle atrophy and paralysis. In this study, we investigated the disease modifying potential of reduced EphA4 protein levels in the SMNΔ7 mouse model for severe SMA. Reduction of EphA4 did not improve motor function, survival, motor neuron survival or NMJ innervation. Our data suggest that either lowering EphA4 has limited therapeutic potential in SMA or that the clinical severity hampers the potential beneficial role of EphA4 reduction in this mouse model for SMA.
Dielectric Planar Defects in Colloidal Photonic Crystal Films (2004)

A straightforward synthetic route to produce colloidal photonic crystals containing dielectric planar defects of controlled thickness (see Figure) is presented. Allowed states that arise within the stop band as a result of this doping greatly modify the reflectance properties of the crystals, in good agreement with theoretical predictions.
Combined Use of CFTR Correctors in LGMD2D Myotubes Improves Sarcoglycan Complex Recovery (2020)

Sarcoglycanopathies are rare limb girdle muscular dystrophies, still incurable, even though symptomatic treatments may slow down the disease progression. Most of the disease-causing defects are missense mutations leading to a folding defective protein, promptly removed by the cell's quality control, even if possibly functional. Recently, we repurposed small molecules screened for cystic fibrosis as potential therapeutics in sarcoglycanopathy. Indeed, cystic fibrosis transmembrane regulator (CFTR) correctors successfully recovered the defective sarcoglycan-complex in vitro. Our aim was to test the combined administration of some CFTR correctors with C17, the most effective on sarcoglycans identified so far, and evaluate the stability of the rescued sarcoglycan-complex. We treated differentiated myogenic cells from both sarcoglycanopathy and healthy donors, evaluating the global rescue and the sarcolemma localization of the mutated protein, by biotinylation assays and western blot analyses. We observed the additive/synergistic action of some compounds, gathering the first ideas on possible mechanism/s of action. Our data also suggest that a defective α-sarcoglycan is competent for assembly into the complex that, if helped in cell traffic, can successfully reach the sarcolemma. In conclusion, our results strengthen the idea that CFTR correctors, acting probably as proteostasis modulators, have the potential to progress as therapeutics for sarcoglycanopathies caused by missense mutations.
<title>Color holography using DuPont holographic recording films</title> (1995)

DuPont has developed holographic photopolymer films capable of producing high diffraction efficiency in full-color volume holograms and holographic optical elements. The properties of these films allows for a greater range of applications than has been considered feasible for color holograms. The recording mechanism and methods for holographic color recording in these materials is considered. Methods for full-color mastering and copying to achieve optimal performance in three-color recording are discussed. Examples of full-color holograms are presented.
Multi-Source Transfer of Delexicalized Dependency Parsers (2011)

We present a simple method for transferring dependency parsers from source languages with labeled training data to target languages without labeled training data. We first demonstrate that delexicalized parsers can be directly transferred between languages, producing significantly higher accuracies than unsupervised parsers. We then use a constraint driven learning algorithm where constraints are drawn from parallel corpora to project the final parser. Unlike previous work on projecting syntactic resources, we show that simple methods for introducing multiple source languages can significantly improve the overall quality of the resulting parsers. The projected parsers from our system result in state-of-the-art performance when compared to previously studied unsupervised and projected parsing systems across eight different languages.
High-sensitivity microfluidic calorimeters for biological and chemical applications (2009)

High-sensitivity microfluidic calorimeters raise the prospect of achieving high-throughput biochemical measurements with minimal sample consumption. However, it has been challenging to realize microchip-based calorimeters possessing both high sensitivity and precise sample-manipulation capabilities. Here, we report chip-based microfluidic calorimeters capable of characterizing the heat of reaction of 3.5-nL samples with 4.2-nW resolution. Our approach, based on a combination of hard- and soft-polymer microfluidics, provides both exceptional thermal response and the physical strength necessary to construct high-sensitivity calorimeters that can be scaled to automated, highly multiplexed array architectures. Polydimethylsiloxane microfluidic valves and pumps are interfaced to parylene channels and reaction chambers to automate the injection of analyte at 1 nL and below. We attained excellent thermal resolution via on-chip vacuum encapsulation, which provides unprecedented thermal isolation of the minute microfluidic reaction chambers. We demonstrate performance of these calorimeters by resolving measurements of the heat of reaction of urea hydrolysis and the enthalpy of mixing of water with methanol. The device structure can be adapted easily to enable a wide variety of other standard calorimeter operations; one example, a flow calorimeter, is described.
<title>New robust bias control method for optical modulators</title> (1990)

For analog signal applications, lithium niobate Mach-Zehnder modulators are biased at the V pi/2 operating point to achieve maximum dynamic range and minimum signal distortion. Even a slight deviation from this optimum bias point causes severe reduction in the available dynamic range. Because of device instabilities, the bias voltage for the optimum operating point can drift with time-requiring constant readjustments. The automatic bias controller described in this paper automatically generates the desired bias voltage to maintain the optimum operating point - even in the presence of modulator drift. The bias controller operates with only one optical tap from the modulator output and is insensitive to variations in the absolute-optical-intensity level.
Voice synthesis utilizing multi-level filter excitation (1991)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Dimitrios P. Prezas, David L. Thomson; Voice synthesis utilizing multi‐level filter excitation. J. Acoust. Soc. Am. 1 July 1991; 90 (1): 626. https://doi.org/10.1121/1.402307 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
USING MOLECULAR MARKERS TO PREDICT OUTCOME (2004)

Emerging technology should allow us to analyze clinical prostate cancer trials with sufficient followup to help develop meaningful markers of prostate cancer progression.
Polyimides Containing Pendent Phosphine Oxide Groups for Space Applications (2002)

As part of an ongoing materials development activity to produce high performance polymers that are durable to the space environment, phosphine oxide containing polyimides have been under investigation. A novel dianhydride was prepared from 2,5-dihydroxyphenyldiphenylphosphine oxide in good yield. The dianhydride was reacted with commercially available diamines, and a previously reported diamine was reacted with commercially available dianhydrides to prepare isomeric polyimides. The physical and mechanical properties, particularly thermal and optical properties, of the polymers were determined. One material exhibited a high glass transition temperature, high tensile properties, and low solar absorptivity. The chemistry, physical, and mechanical properties of these resins will be discussed.
End-to-End Multi-Object Tracking with Global Response Map (2020)

Most existing Multi-Object Tracking (MOT) approaches follow the Tracking-by-Detection paradigm and the data association framework where objects are firstly detected and then associated. Although deep-learning based method can noticeably improve the object detection performance and also provide good appearance features for cross-frame association, the framework is not completely end-to-end, and therefore the computation is huge while the performance is limited. To address the problem, we present a completely end-to-end approach that takes image-sequence/video as input and outputs directly the located and tracked objects of learned types. Specifically, with our introduced multi-object representation strategy, a global response map can be accurately generated over frames, from which the trajectory of each tracked object can be easily picked up, just like how a detector inputs an image and outputs the bounding boxes of each detected object. The proposed model is fast and accurate. Experimental results based on the MOT16 and MOT17 benchmarks show that our proposed on-line tracker achieved state-of-the-art performance on several tracking metrics.
Nanomembrane‐Based, Thermal‐Transport Biosensor for Living Cells (2016)

Knowledge of materials' thermal-transport properties, conductivity and diffusivity, is crucial for several applications within areas of biology, material science and engineering. Specifically, a microsized, flexible, biologically integrated thermal transport sensor is beneficial to a plethora of applications, ranging across plants physiological ecology and thermal imaging and treatment of cancerous cells, to thermal dissipation in flexible semiconductors and thermoelectrics. Living cells pose extra challenges, due to their small volumes and irregular curvilinear shapes. Here a novel approach of simultaneously measuring thermal conductivity and diffusivity of different materials and its applicability to single cells is demonstrated. This technique is based on increasing phonon-boundary-scattering rate in nanomembranes, having extremely low flexural rigidities, to induce a considerable spectral dependence of the bandgap-emission over excitation-laser intensity. It is demonstrated that once in contact with organic or inorganic materials, the nanomembranes' emission spectrally shift based on the material's thermal diffusivity and conductivity. This NM-based technique is further applied to differentiate between different types and subtypes of cancer cells, based on their thermal-transport properties. It is anticipated that this novel technique to enable an efficient single-cell thermal targeting, allow better modeling of cellular thermal distribution and enable novel diagnostic techniques based on variations of single-cell thermal-transport properties.