gebhart/patrepeval huggingface dataset:
Narrow-band single-photon emission in the near infrared for quantum key distribution (2006)

We present a detailed study of photophysical properties of single color centers in natural diamond samples emitting in the near infrared under optical excitation. Photoluminescence of these single emitters has several striking features, including narrow-band (FWHM 2 nm) fully polarized emission around 780 nm, a short excited-state lifetime of about 2 ns, and perfect photostability at room temperature under our excitation conditions. Development of a triggered single-photon source relying on this single color center is discussed for application to quantum key distribution.
Diagnosis and Treatment of Wilson's Disease (1999)

Wilson's disease is due to an inherited defect in copper excretion into the bile by the liver. The resulting copper accumulation and copper toxicity results in liver disease, and in some patients, brain damage. Patients present, generally between the ages of 10 and 40 years, with liver disease, neurological disease of a movement disorder type, or behavioral abnormalities, and often with a combination of these. Because Wilson's disease is effectively treated, it is extremely important for physicians to learn to recognize and diagnose the disease. Treatment options have evolved rapidly in the last few years, with zinc now being the drug of choice in most situations.
Comitetul roman de istoria si filozofia stiintei, <i>Istoria stiintelor in Romania: Lingvistica</i>. [Comité roumain de l’histoire et de la philologie des sciences, <i>L’histoire des sciences en Roumanie: La linguistique</i>]. Publie sous la direction de lorgu lordan par Ion Ghetie, Valeria Gutu Romalo, et al. (1977)

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Modelo de Empresa sistêmica (2007)

Com este artigo, a luz de uma abordagem sistemica desenvolvida por Anne Versailles (2004) e adaptada por Marcelo Cabeda (2004) e pela turma de alunos da cadeira de Gestao Sistemica, do curso de Administracao da ULBRA Sao Jeronimo 2007_1, desenvolve-se em conjunto um estudo que culmina com a proposta de um modelo generico para a gestao sistemica das empresas. Destaca-se aqui como inovacao o modelo de organograma da empresa Figura-chave 9, no qual o cliente-comprador ocupa o centro do negocio
Ensuring Public Safety Organisations' Information Flow and Situation Picture in Hybrid Environments (2018)

This article describes how Public Safety Organisations (PSO) come up against hybrid, demanding operations like terrorist attack or school shootings more frequently. Obtaining a realistic situation picture is crucial in organising the rescue operation and in minimising further violence. The role of PSOs' 24/7 situation centres becomes vital. In this paper, the authors explore how PSOs can ensure an information flow and a situation picture in hybrid environments. The empirical data were official reports and the data collected through interviews with staff at different PSOs. It was analysed using qualitative content analysis. Achieving a common operational picture involves taking account of each authority's needs and constraints, thereby enabling the exchange of relevant information between key authorities on-scene and off-scene. In addition, human factors play an important role in complex, multi-authority missions. Furthermore, the increasing role of citizens and social media in producing valuable information should not be overlooked.
Accuracy of refractive outcomes in myopic and hyperopic laser in situ keratomileusis: Manifest versus aberrometric refraction (2012)

Dr. Reinstein is a consultant to Carl Zeiss Meditec AG and has a proprietary interest in the Artemis technology (Arcscan Inc., Morrison, Colorado, USA) through patents administered by the Cornell Center for Technology Enterprise and Commercialization, Ithaca, New York. No other author has a financial or proprietary interest in any material or method mentioned.
Length quantization in In0.13Ga0.87As/GaAs quantum boxes with rectangular cross section (1997)

By electron-beam lithography and wet chemical etching quantum boxes with a controlled shape as, e.g., a rectangular cross section, can be realized. We have fabricated quantum boxes with approximately constant widths of 50–60 nm and strongly varying lengths (150–80 nm). The luminescence of the structures shows a shift of the ground-state emission to higher energy as well as transitions between excited box states. By comparison with model calculations the changes of the emission spectra are related to the length quantization in the structures.
Measurement and analysis of cryogenic sapphire dielectric resonators and DROs (1987)

Presented are the experimental and computational results of a study on a new kind of dielectric resonator oscillator (DRO). It consists of a cooled, cylindrically symmetric sapphire resonator surrounded by a metallic shield and is capable of higher Q's than any other dielectric resonator. Isolation of fields to the sapphire by the special nature of the electromagnetic mode allows the very low loss of the sapphire itself to be expressed. Calculations show that the plethora of modes in such resonators can be effectively reduced through the use of a ring resonator with appropriate dimensions. Experimental results show Q's ranging from 3 x 10 to the 8th at 77 K to 10 to the 9th at 4.2 K. Performance is estimated for several types of DROs incorporating these resonators. Phase noise reductions in X-band sources are indicated at values substantially lower than those previously available.
Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium (2015)

Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vitamin D3 effects are thought to be largely mediated by the metabolite 1,25(OH)2D3. Reduced serum levels of the most commonly measured precursor metabolite, 25(OH)D3, is linked to an increased risk of multiple inflammatory diseases, including: cardiovascular disease, arthritis, multiple sclerosis, and sepsis. Common to all of these diseases is the disruption of endothelial stability and an enhancement of vascular leak. We previously performed an unbiased chemical suppressor screen on a genetic model of vascular instability, and identified cholecalciferol (D3, dietary Vitamin D3) as a factor that had profound and immediate stabilizing and therapeutic effects in that model. In this manuscript we show that the presumed inactive sterol, D3, is actually a potent and general mediator of endothelial stability at physiologically relevant concentrations. We further demonstrate that this phenomenon is apparent in vitamin D3 metabolites 25(OH)D3 and 1,25(OH)2D3, and that the effects are independent of the canonical transcription-mediated vitamin D pathway. Our data suggests the presence of an alternative signaling modality by which D3 acts directly on endothelial cells to prevent vascular leak. The finding that D3 and its metabolites modulate endothelial stability may help explain the clinical correlations between low serum vitamin D levels and the many human diseases with well-described vascular dysfunction phenotypes.
Butting Monoliths in Catalytic Converters (1996)

<div class="htmlview paragraph">Most catalytic converter designs today utilize monolith type catalyst supports. Many of these designs use more than one monolith because of different catalyst loadings, or constraints on the manufacture or coating of long monoliths. Usually a space exists between the monoliths. Traditional thinking has been that spacing was necessary for enhanced emissions, reduced flow restriction, or concerns about the physical integrity of the monoliths.</div> <div class="htmlview paragraph">This paper presents the concept of eliminating the space, and butting the monoliths together as a viable converter assembly technique. Major benefits include simplified assembly, reduced number of components and cost, and improved durability, with no major effects on emissions or flow restriction.</div>
Finding Route Hotspots in Large Labeled Networks (2019)

In many advanced network analysis applications, like social networks, e-commerce, and network security, hotspots are generally considered as a group of vertices that are tightly connected owing to the similar characteristics, such as common habits and location proximity. In this paper, we investigate the formation of hotspots from an alternative perspective that considers the routes along the network paths as the auxiliary information, and attempt to find the route hotspots in large labeled networks. A route hotspot is a cohesive subgraph that is covered by a set of routes, and these routes correspond to the same sequential pattern consisting of vertices' labels. To the best of our knowledge, the problem of Finding Route Hotspots in Large Labeled Networks has not been tackled in the literature. However, it is challenging as counting the number of hotspots in a network is #P-hard. Inspired by the observation that the sizes of hotspots decrease with the increasing lengths of patterns, we prove several anti-monotonicity properties of hotspots, and then develop a scalable algorithm called FastRH that can use these properties to effectively prune the patterns that cannot form any hotspots. In addition, to avoid the duplicate computation overhead, we judiciously design an effective index structure called RH-Index for storing the hotspot and pattern information collectively, which also enables incremental updating and efficient query processing. Our experimental results on real-world datasets clearly demonstrate the effectiveness and scalability of our proposed methods.
Evolution of Classified Administration of Enterprises and the Harmonization of AEO System in Chinese Customs Reform (2016)

With the effectiveness of AEO mutual recognition agreement between EU and China on 1 November 2015, China intensifies its AEO harmonization with other trade partners. In this context, this article first considers the framework of classified administration of enterprises and AEO system in China and discusses the latest development. Further reform of AEO system in China is to strengthen credit-based administration and improve the efficiency of customs clearance for domestic and foreign certified importers and exporters. The article also provides a review of administration concept of General Administration of Customs of China in various stages: risk management concept, classified administration concept and credit-based administration concept. By comparison with the AEO implementation in EU, the article suggests customs regulatory measures shall focus more on global standardization and compliance, as well as improve accessibility of SMEs to AEO status by establishing screening procedure and special guidance etc.
The Conduits and Barriers to Reentry for Formerly Incarcerated Individuals in San Bernardino (2018)

Numerous scholars have noted that the majority of prisoners will be reincarcerated within three years of their release. However, while there has been extensive research on recidivism, much less attention has been paid to the reentry process in the sociological and criminological literature. Given the high rates of former prisoners reentering society with struggles that may affect their friends, family members, and communities, policymakers and practitioners should understand the successful methods for their reintegration. In this paper, we explore the conduits and barriers to reentry for a sample of San Bernardino county callers using United Way’s 211 Reentry Call Center from 2014-2015. We find that human needs resources (i.e. housing, clothes, and food assistance) and legal assistance are the two most frequently requested services. The callers in our sample have intersecting, disadvantaged identities and require multiple services which suggests a need for collaboration across agencies.
Regulation of μ-Opioid Receptor Gene Transcription by Interleukin-4 and Influence of an Allelic Variation within a STAT6 Transcription Factor Binding Site (2001)

Morphine and the endogenous opioid peptide beta-endorphin exert neuromodulatory as well as immunomodulatory effects, which are transduced by mu-opioid receptors. In this report we show that stimulation with interleukin-4 induces mu-opioid receptor transcripts in human primary blood cells (T cells and polymorphonuclear leukocytes), immune cell lines (Raji, U-937, and HMEC-1), and dendritic cells. In nonstimulated immune cells this gene is silent. In addition, mu receptor transcription is up-regulated by interleukin-4 in cultures of primary rat neurons. Transient transfection experiments in Raji and SH SY5Y neuronal cells with human and rat reporter gene constructs linked the interleukin-4 effect directly to cis-active mu receptor promoter elements located at nucleotide -997 on the human gene and nucleotide -727 on the rat gene. The interleukin-4 response elements function orientation independently. They bind STAT6 transcription factors as shown by electrophoretic mobility shift assays. In the human gene, a single nucleotide polymorphism within the interleukin-4 response element reduces the trans-activating potential of this element by 50%, which may affect the phenotype of persons carrying this variation. These findings provide a molecular basis for understanding bidirectional interactions between the opioid system and the immune system.
Differential electrophysiological properties of dopamine D1 and D2 receptor‐containing striatal medium‐sized spiny neurons (2008)

The electrophysiological properties of distinct subpopulations of striatal medium-sized spiny neurons (MSSNs) were compared using enhanced green fluorescent protein as a reporter gene for identification of neurons expressing dopamine D1 and D2 receptor subtypes in mice. Whole-cell patch-clamp recordings in slices revealed that passive membrane properties were similar in D1 and D2 cells. All MSSNs displayed hyperpolarized resting membrane potentials but the threshold for firing action potentials was lower in D2 than in D1 neurons. In voltage clamp, the frequency of spontaneous excitatory postsynaptic currents was higher in D2 than in D1 cells and large-amplitude inward currents (> 100 pA) were observed only in D2 cells. After tetrodotoxin this difference was reduced, suggesting that sodium conductances contribute to the increased frequencies in D2 cells. After pharmacological blockade of GABA(A) receptors, a subset of D2 cells also displayed large spontaneous membrane depolarizations and complex responses to stimulation of the corticostriatal pathway. To further characterize ionotropic glutamate receptor function, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) was applied onto dissociated MSSNs. Application of AMPA alone or in the presence of cyclothiazide (an AMPA receptor desensitization blocker) evoked larger currents in D1 than in D2 cells. Together, these data demonstrate significant differences in electrophysiological properties of subpopulations of MSSNs defined by selective expression of D1 and D2 receptors. D2 cells display increased excitability and reflect ongoing cortical activity more faithfully than D1 cells, an effect that is independent of postsynaptic AMPA receptors and probably results from stronger synaptic coupling. This could help to explain the increased vulnerability of D2 MSSNs in neurodegenerative disorders.
Hierarchical nanomechanics of collagen microfibrils (2010)

Abstract Collagen constitutes one third of the human proteome, providing mechanical stability, elasticity and strength to connective tissues. Collagen is also the dominating material in the extracellular matrix (ECM) and is thus crucial for cell differentiation, growth and pathology. However, fundamental questions remain with respect to the origin of the unique mechanical properties of collagenous tissues, and in particular its stiffness, extensibility and nonlinear mechanical response. By using x-ray diffraction data of a collagen fibril reported by Orgel et al. (Proceedings of the National Academy of Sciences USA, 2006) in combination with protein structure identification methods, here we present an experimentally validated model of the nanomechanics of a collagen microfibril that incorporates the full biochemical details of the amino acid sequence of the constituting molecules. We report the analysis of its mechanical properties under different levels of stress and solvent conditions, using a full-atomistic force field including explicit water solvent. Mechanical testing of hydrated collagen microfibrils yields a Young’s modulus of ≈300 MPa at small and ≈1.2 GPa at larger deformation in excess of 10% strain, in excellent agreement with experimental data. Dehydrated, dry collagen microfibrils show a significantly increased Young’s modulus of ≈1.8 to 2.25 GPa (or ≈6.75 times the modulus in the wet state) owing to a much tighter molecular packing, in good agreement with experimental measurements (where an increase of the modulus by ≈9 times was found). Our model demonstrates that the unique mechanical properties of collagen microfibrils can be explained based on their hierarchical structure, where deformation is mediated through mechanisms that operate at different hierarchical levels. Key mechanisms involve straightening of initially disordered and helically twisted molecules at small strains, followed by axial stretching of molecules, and eventual molecular uncoiling at extreme deformation. These mechanisms explain the striking difference of the modulus of collagen fibrils compared with single molecules, which is found in the range of 4.8±2 GPa or ≈10-20 times greater. These findings corroborate the notion that collagen tissue properties are highly scale dependent and nonlinear elastic, an issue that must be considered in the development of models that describe the interaction of cells with collagen in the extracellular matrix. A key impact the atomistic model of collagen microfibril mechanics reported here is that it enables the bottom-up elucidation of structure-property relationships in the broader class of collagen materials such as tendon or bone, including studies in the context of genetic disease where the incorporation of biochemical, genetic details in material models of connective tissue is essential.
Suppressors of cytokine signalling: SOCS (2002)

The mechanism of positive regulation of cytokine signalling pathways has been well investigated, whereas our knowledge of negative regulation is relatively sparse. Here we review recent literature on important negative regulators: the family of suppressors of cytokine signalling, SOCS, consisting of eight members (SOCS-1 to SOCS-7 and CIS) all sharing a central SH2 domain and a C-terminal SOCS box. Expression of CIS, SOCS-1, SOCS-2 and SOCS-3 is induced by various cytokines, and overexpression studies in various cell lines have demonstrated their inhibitory roles. These family members have been implicated in the negative regulation of several pathways, particularly the JAK/STAT pathway, and since this signalling pathway is responsible for their induction, they form part of a classical negative feedback circuit. To date, at least three different modulating mechanisms have been demonstrated: through the SH2 domain they bind to phosphotyrosines on the target protein, leading to inhibition of signal transduction by N-terminal inactivation of JAK, by blocking access of STAT to the receptor sites, or by SOCS box-targeting bound proteins to proteasomal degradation. In gene modification studies in mice, it has been demonstrated that SOCS-1 plays an important role in IFNgamma-regulation and T-cell differentiation, while SOCS-2 seems necessary for normal growth regulation. SOCS-3(-/-) mice die during embryogenesis for a reason still not fully understood, but insufficient control of fetal erythropoiesis or defects in placental development may be involved. The physiological role for the other family members, as well as their molecular regulation mechanisms, remain to be revealed.
Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease (2018)

It is estimated that Alzheimer’s disease (AD) affects tens of millions of people, comprising not only suffering patients, but also their relatives and caregivers. AD is one of age-related neurodegenerative diseases (NDs) characterized by progressive synaptic damage and neuronal loss, which result in gradual cognitive impairment leading to dementia. The cause of AD remains still unresolved, despite being studied for more than a century. The hallmark pathological features of this disease are senile plaques within patients’ brain composed of amyloid beta (Aβ) and neurofibrillary tangles (NFTs) of Tau protein. However, the roles of Aβ and Tau in AD pathology are being questioned and other causes of AD are postulated. One of the most interesting theories proposed is the causative role of amyloid β oligomers (AβOs) aggregation in the pathogenesis of AD. Moreover, binding of AβOs to cell membranes is probably mediated by certain proteins on the neuronal cell surface acting as AβO receptors. The aim of our paper is to describe alternative hypotheses of AD etiology, including genetic alterations and the role of misfolded proteins, especially Aβ oligomers, in Alzheimer’s disease. Furthermore, in this review we present various putative cellular AβO receptors related to toxic activity of oligomers.
Chronic obstructive pulmonary disease (2023)

Abstract This chapter outlines the guidance on COPD. It provides a clear overview for the junior doctor in a clinical setting.
The Application of Multi-domain Physical System Simulation Method in the Study of Automatic Transmissions (2009)

This paper presents the application of multi-domain physical system simulation method in the study of automatic transmissions which involve mechanics, electronics, and hydraulics. Based on the multi-domain modeling and simulation tool ITI-SimulationX , the sub models of a automatic transmission are modeled and simulated in a multi-domain way, including the torque convert sub model, planetary gear sets sub model, and hydraulic control system sub model. The simulation results are analyzed and some are compared with the test results condition-permittedly. The analysis and comparison make clear that the application of multi-domain physical system simulation method is able to simplify the study of multiplex physical system that involve mechanics, electronics, and hydraulics etc. Accordingly researchers can escape from solving mathematical models and can pay more attentions to the study of physical system.
Wave-equation trace interpolation (1987)

Abstract Spatial aliasing in multichannel seismic data can be overcome by solving an inversion in which the model is the section that would be recorded in a well sampled zero-offset experiment, and the data are seismic data after normal moveout (NMO). The formulation of the (linear) relation between the data and the model is based on the wave equation and on Fourier analysis of aliasing. A processing sequence in which one treats missing data as zero data and performs partial migration before stacking is equivalent to application of the transpose of the operator that actually needs to be inverted. The inverse of that operator cannot be uniquely determined, but it can be estimated using spatial spectral balancing in a conjugate-gradient iterative scheme. The first iteration is conventional processing (including prestack partial migration). As shown in a field data example in which severe spatial aliasing was simulated, a few more iterations are necessary to achieve significantly better results.