gebhart/patrepeval huggingface dataset:
O corpo (u)tópico e o espaço heterotópico dos quilombolas hoje: uma análise discursiva foucaultiana (2022)

Neste artigo, discutimos a noção de quilombo como um espaço heterotópico para o corpo negro, tanto na sua jornada em busca de liberdade em relação ao disciplinamento do sistema colonial como na atualidade. Para tanto, analisamos dois enunciados jornalísticos e entrevistas que realizamos com dois sujeitos residentes em comunidades quilombolas do estado do Maranhão (MA). O aporte teórico-metodológico que ancora essa discussão repousa nos Estudos Discursivos Foucaultianos, assentados na proposta de análise enunciativa de Michel Foucault (2008), a qual nos possibilita empreender uma investigação com base nos princípios de regularidade, dispersão, raridade e campo associado entre enunciados. Conclui-se que o quilombo emerge no domínio da história como uma forma de buscar a liberdade em relação ao poder disciplinador colonial, mas o corpo do sujeito negro é reinscrito em espaços heterotópicos nos quais sofre formas de exclusão, violência e estigmas até o presente.
Automatic Annotation of Formula 1 Races for Content-Based Video Retrieval (2001)

Content-based video retrieval is emerging as an important part in the process of utilization of various multimedia documents. In this report we present a novel system for the automatic indexing and content-based retrieval of multimedia documents. We chose the domain of Formula 1 sport videos because the manual annotation of Formula 1 races is complicated and time consuming. Our system uses multi-modal clues, obtained from three different multimedia components: audio, video, and superimposed text. The audio and video feature extraction subsystems are developed to extract important parameters from multimedia documents. We also performed text detection and recognition to extract some semantic information superimposed in the Formula 1 race video. To unify the audio and video clues we employed dynamic Bayesian networks. Many experiments that we carried out are also presented, as well as the results and conclusions drawn from them. 1.
Cash is the bloodline of any successful business : accounting technical (2015)

Many entrepreneurs and owners of SMEs are under the impression that the profit they make is equal to the cash the business generates and often overcommit the business with financial obligations. Research throughout the world indicates that 33.7% of SMEs are liquidated as a direct cause of cash flow difficulties. In South Africa, research indicates that approximately 100 SMEs are liquidated monthly, with the primary cause being cash flow difficulties and the inability to meet their financial obligations.
Cover Image (2018)

The cover image, by Wen-qing Zhu et al., is based on the Research Article Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3-E1 osteoblasts, DOI: 10.1002/jat.3590.
Intelligent control in traffic management (2002)

The goal of an advanced traffic management system (ATMS) is to efficiently manage existing transportation resources in response to dynamic traffic conditions. The utility of an ATMS will greatly depend upon its ability to adaptively respond to traffic patterns and permutations. The application of knowledge-based systems and neural networks provides an ATMS with the technology required to control traffic in an intelligent manner. The volume of traffic combined with the number of streets and intersections an operator control station must monitor clearly dictates the need for computer support. Integrating these technologies with existing transportation methodologies produces a semi-autonomous system capable of reducing operator workloads while maintaining high levels of safety. This paper describes an intelligent traffic management control system called TERMINUS developed to adaptively respond to real-time traffic management problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Diversity and Abundance of the Bacterial Community of the Red Macroalga Porphyra umbilicalis: Did Bacterial Farmers Produce Macroalgae? (2013)

Macroalgae harbor microbial communities whose bacterial biodiversity remains largely uncharacterized. The goals of this study were 1) to examine the composition of the bacterial community associated with Porphyra umbilicalis Kützing from Schoodic Point, ME, 2) determine whether there are seasonal trends in species diversity but a core group of bacteria that are always present, and 3) to determine how the microbial community associated with a laboratory strain (P.um.1) established in the presence of antibiotics has changed. P. umbilicalis blades (n = 5, fall 2010; n = 5, winter 2011; n = 2, clonal P.um.1) were analyzed by pyrosequencing over two variable regions of the 16 S rDNA (V5-V6 and V8; 147,880 total reads). The bacterial taxa present were classified at an 80% confidence threshold into eight phyla (Bacteroidetes, Proteobacteria, Planctomycetes, Chloroflexi, Actinobacteria, Deinococcus-Thermus, Firmicutes, and the candidate division TM7). The Bacteroidetes comprised the majority of bacterial sequences on both field and lab blades, but the Proteobacteria (Alphaproteobacteria, Gammaproteobacteria) were also abundant. Sphingobacteria (Bacteroidetes) and Flavobacteria (Bacteroidetes) had inverse abundances on natural versus P.um.1 blades. Bacterial communities were richer and more diverse on blades sampled in fall compared to winter. Significant differences were observed between microbial communities among all three groups of blades examined. Only two OTUs were found on all 12 blades, and only one of these, belonging to the Saprospiraceae (Bacteroidetes), was abundant. Lewinella (as 66 OTUs) was found on all field blades and was the most abundant genus. Bacteria from the Bacteroidetes, Proteobacteria and Planctomycetes that are known to digest the galactan sulfates of red algal cell walls were well-represented. Some of these taxa likely provide essential morphogenetic and beneficial nutritive factors to P. umbilicalis and may have had unexpected effects upon evolution of macroalgal form as well as function.
Surface Modification of Detonation Nanodiamonds with Platinum and Palladium Nanoparticles (2014)

Acetylacetonates of platinum group metals (M(acac)n, acac= CH3COCHCOCH3, n - oxidation state of metal) are the most suitable precursors for use in highly effective MOCVD (metal-organic chemical vapor deposition) processes because of their thermal properties, low price of initial ligand and accessible synthesis methods. In this study we have developed a simple, scalable inexpensive, MOCVD-like approach to the deposition of Pt and Pd nanoparticle dispersions on powder detonation nanodiamonds (DND) using combustion in air of powder mixtures of DND with Pt and Pd acetylacetonates. This one-step process requires no specialized apparatus, and is conducted at mild temperatures (180oC – 250oC). The substrate surface of DND initiates chemical thermal destruction of precursor and deposition of nanoparticle networks composed of constituent particles. DND-supported Pd and Pt nanoparticles with their loading being from 10 and 5wt. % were obtained the average of particle size 20-25 nm and 7-10nm decreases with decreasing the metal loading. For additional purification and disaggregation of the commercial detonation-synthesized nanodiamond (DNDcomm) the method of annealing of the powder mixtures DNDcomm with Na(acac) have been used. The purified diamond nanoparticulates (DND), as well as DNDcomm, Pt/DND and Pd/DND, were subjected to physicochemical characterizations, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) analysis.
Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects (2016)

Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disease caused by mutations in the gene encoding the WAS protein (WASp). Here, induced pluripotent stem cells (iPSCs) were derived from a WAS patient (WAS-iPSC) and the endogenous chromosomal WAS locus was targeted with a wtWAS-2A-eGFP transgene using zinc finger nucleases (ZFNs) to generate corrected WAS-iPSC (cWAS-iPSC). WASp and GFP were first expressed in the earliest CD34(+)CD43(+)CD45(-) hematopoietic precursor cells and later in all hematopoietic lineages examined. Whereas differentiation to non-lymphoid lineages was readily obtained from WAS-iPSCs, in vitro T lymphopoiesis from WAS-iPSC was deficient with few CD4(+)CD8(+) double-positive and mature CD3(+) T cells obtained. T cell differentiation was restored for cWAS-iPSCs. Similarly, defects in natural killer cell differentiation and function were restored on targeted correction of the WAS locus. These results demonstrate that the defects exhibited by WAS-iPSC-derived lymphoid cells were fully corrected and suggests the potential therapeutic use of gene-corrected WAS-iPSCs.
Synthetic and spectroscopic studies of phosphoranides [PR(CN)2X]? and the crystal and molecular structure of [NEt4][PPh(CN)2Cl] (1990)

Several new phosphoranides of the type [NR4][PR′(CN)2X](R′= Me, Et, Ph, or C6F5; X = Cl, Br, I, or NCS) have been synthesised, and characterised by means of 31P n.m.r. spectroscopy, elemental analysis, and (in some cases) i.r. spectroscopy. These are the first simple phosphoranides to be prepared with an organo group bound directly to phosphorus. Determination of the crystal structure of [Net4][PPh(CN)2Cl] has shown a monomeric distorted ψ-trigonal bipyramidal geometry for the anion, with the phenyl group equatorial and one very long P–Cl axial bond, as observed previously in the [PCl4]– ion. Halide ions did not form phosphoranides with PBut(CN)2, PMe2(CN), or PPh2(CN).
Structural Effects Affecting the Thermal Electrocyclic Ring Closure of Vinylallenes to Alkylidenecyclobutenes (1996)

The thermal electrocyclic ring closure of (2E,7E)-3,4,7-trialkylnona-2,4,5,7-tetraenes (divinyl-4,5-allenes) is regioselective, occurring at the most sterically congested vinylallene subunit to afford the trisubstituted alkylidenecyclobutene. Ring closure of both divinylallenes and vinylallenes displays high torquoselectivity (exclusive formation of the (E)-alkylidenecyclobutenes) when the substituent at C4 is a sterically demanding alkyl group and the substituent at C2 is a formyl group. Ab initio calculations clearly demonstrate the dominant steric influence of the bulky C4 substituent in these selectivities. However, torquoselectivity appears to be enhanced if cyclization involves loss of conjugation by a π system encompassing the C2 substituent.
Runtime reconfiguration of time-sensitive networking (TSN) schedules for Fog Computing (2017)

Fog Computing is about to tremendously impact the industrial automation industry. While, today's industrial automation systems use proprietary technology to provide real-time and dependability guarantees, Fog Computing enables a paradigm shift from this proprietary operations technology (OT) to the usage of standard IT equipment and infrastructure. Thus, Fog Computing is one of the key elements of the Industrial Internet of Things and Industry 4.0. In particular, future Fog Computing will be enabled by: the increased usage of IP-protocols, e.g., standardized Deterministic Ethernet solutions from IEEE Time-Sensitive Networking (TSN) Task Group, upcoming 5G wireless standards, and interoperability standards such as OPC Unified Architecture (OPC UA). In this paper, we address the runtime reconfiguration of TSN-based Fog Computing platforms. We assume that the Fog Computing platform is composed of several heterogeneous Fog Nodes interconnected using TSN. The applications consist of hard real-time control tasks, which have strict timing requirements expressed as hard deadlines. For time-critical traffic, TSN uses the scheduled traffic type, which relies on Gate-Control Lists (GCLs) at each outgoing port of a network switch to decide the transmission of scheduled frames. We propose a heuristic algorithm to determine the GCLs at runtime such that the deadlines are satisfied and the queue usage is minimized, to accommodate non-critical traffic. The scheduling algorithm is part of a configuration agent that reacts to network changes and reconfigures the GCLs using the NETCONF network configuration protocol. Our experimental evaluation shows that the scheduling heuristic is able to quickly find good-quality GCLs.
Improving the performance of runtime parallelization (1993)

When the inter-iteration dependency pattern of the iterations of a loop cannot be determined statically, compile time parallelization of the loop is not possible. In these cases, runtime parallelization [8] is the only alternative. The idea is to transform the loop into two code fragements: the inspector and the executor. When the program is run, the inspector examines the iteration dependencies and constructs a parallel schedule. The executor subsequently uses that schedule to carry out the actual computation in parallel.
Chemical and Pharmacological Aspects of Capsaicin (2011)

Capsaicin is a unique alkaloid found primarily in the fruit of the Capsicum genus and is what provides its spicy flavor. Generally extracted directly from fruit, high demand has driven the use of established methods to increase production through extraction and characterization. Over time these methods have improved, usually be applying existing techniques in conjunction. An increasingly wide range of potential applications has increased interest in capsaicin. Especially compelling are the promising results of medical studies showing possible beneficial effects in many diseases. Capsaicin's pungency has limited its use in clinical trials to support its biological activity. Characterization and extraction/ synthesis of non-pungent analogues is in progress. A review is made of capsaicin research focusing mainly on its production, synthesis, characterization and pharmacology, including some of its main potential clinical uses in humans.
Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications (2017)

Esophageal cancer ranks among the most aggressive malignant diseases. The limited improvements in treatment outcomes provided by conventional therapies have prompted us to seek innovative strategies for treating this cancer. More than 100 trillion microorganisms inhabit the human intestinal tract and play a crucial role in health and disease conditions, including cancer. The human intestinal microbiome is thought to influence tumor development and progression in the gastrointestinal tract by various mechanisms. For example, <i>Fusobacterium nucleatum</i>, which primarily inhabits the oral cavity and causes periodontal disease, might contribute to aggressive tumor behavior through activation of chemokines such as CCL20 in esophageal cancer tissue. Composition of the intestinal microbiota is influenced by diet, lifestyle, antibiotics, and pro- and prebiotics. Therefore, by better understanding how the bacterial microbiota contributes to esophageal carcinogenesis, we might develop novel cancer prevention and treatment strategies through targeting the gastrointestinal microflora. This review discusses the current knowledge, available data and information on the relationship of microbiota with esophagitis, Barrett's esophagus, esophageal adenocarcinoma and squamous cell carcinoma.
One-way, real time wave front converters (1986)

Optical one-way, real time wave front cleanup by means of photorefractively pumped oscillators is reported. A factor of 4000 increase in beam brightness has been achieved.
Hardware efficient frequency estimator based on data-aided algorithm for digital video broadcasting system (2008)

This paper presents an efficient frequency estimator for digital video broadcasting - second generation (DVB-S2). Analyzing the robust algorithm among data-aided approaches, we find that the Luise & Reggiannini (L&R) algorithm is the most suitable one for coarse frequency estimation with respect to estimation performance and complexity. However, it requires many multipliers and adders to compute output values of correlators. We propose an efficient architecture identifying the serial correlator with the buffer and multiplexers. The proposed coarse frequency estimator can reduce the hardware complexity about 92% of the direct implementation. The proposed architecture has been implemented and verified on the Xilinx Virtex II FPGA.
Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode,<i>Protospirura muricola</i>,<i>in vitro</i>and<i>in vivo</i> (2006)

Cysteine proteinases from the fruit and latex of plants, including papaya, pineapple and fig, were previously shown to have a rapid detrimental effect, in vitro, against the rodent gastrointestinal nematodes, Heligmosomoides polygyrus (which is found in the anterior small intestine) and Trichuris muris (which resides in the caecum). Proteinases in the crude latex of papaya also showed anthelmintic efficacy against both nematodes in vivo. In this paper, we describe the in vitro and in vivo effects of these plant extracts against the rodent nematode, Protospirura muricola, which is found in the stomach. As in earlier work, all the plant cysteine proteinases examined, with the exception of actinidain from the juice of kiwi fruit, caused rapid loss of motility and digestion of the cuticle, leading to death of the nematode in vitro. In vivo, in contrast to the efficacy against H. polygyrus and T. muris, papaya latex only showed efficacy against P. muricola adult female worms when the stomach acidity had been neutralized prior to administration of papaya latex. Therefore, collectively, our studies have demonstrated that, with the appropriate formulation, plant cysteine proteinases have efficacy against nematodes residing throughout the rodent gastrointestinal tract.
Erosion Resistance of Thick Nitride and Carbonitride Coatings Deposited using Plasma Enhanced Magnetron Sputtering (2007)

In this paper, we report the microstructural and erosion test results of thick coatings deposited using a PEMS technique. Nitrides (TiN, CrN, and ZrN) and nanocomposite carbonitride (TiSiCN) were deposited on Ti-6Al-4V disk coupon and turbine blade samples. The samples were analyzed using SEM with energy dispersive EDS, nanoindentation, and XRD. Selected samples were subjected to alumina erosion tests separately using two incident angles (30° and 90°, respectively). The nanohardness of the nitride coatings was 30 GPa for carbonitride. It was observed that at 30° TiSiCN renders the best erosion resistance. At 90° incidence, the erosion damage becomes more severe. However, one TiSiCN sample still showed an order of magnitude improved erosion resistance over the commercial TiN while delamination occurred on other samples. The delamination is believed to be the result of high internal stress of the TiSiCN coatings. A multilayered TiSiCN/Ti coating is proposed to maintain the high erosion resistance while reducing the internal stress. It is believed that this technology, once fully developed, may be applied to protect turbine engine blades and vanes from both solid particle erosion (SPE) and liquid droplet erosion (LDE) as well as piston rings of heavy-duty diesel engines from wear.
Leptin receptor expression and cell signaling in breast cancer (2006)

Obesity is considered a risk factor for many cancers, including breast cancer. Our laboratory has previously shown that leptin is mitogenic in many cancer cell lines, including breast. Information regarding the effects of high leptin levels on leptin receptor expression and signaling is lacking. The purpose of this study was to characterize leptin receptor expression in response to leptin in breast cancer cells. In addition, SOCS-3 expression (a leptin inducible inhibitor of leptin signaling), plus MAPK and PI3K signaling, were examined to determine their role in leptin-induced cell proliferation. Breast cancer cell lines, ZR75-1 and HTB-26, were treated with 0, 4, 40 or 80 ng/ml of leptin. Multiplex RT-PCR was performed to determine relative mRNA expression levels of the human short (huOB-Ra) or long (huOB-Rb) leptin receptor isoforms, or SOCS-3. MAPK and PI3K signaling was analyzed by phosphorylation of ERK and Akt, respectively, via Western blotting. Cell proliferation and inhibitor studies were analyzed by MTT assay. HTB-26 and ZR75-1 both expressed huOB-Ra, huOB-Rb and SOCS-3 mRNA; however, mRNA expression levels generally remained unchanged over time with leptin treatment. MAPK and PI3K pathways were activated in the presence of leptin over time. MAPK and PI3K inhibitors significantly blocked leptin-induced proliferation. Higher levels of circulating leptin contribute to breast cancer proliferation by activation of the MAPK and PI3K signaling pathways involved in cell growth and survival. The mitogenic effects of leptin are not a consequence of altered leptin receptor or SOCS-3 mRNA expression.
The wonder of breast milk. (2013)

This is a summary of key topics that were presented at the 8th International Breastfeeding and Lactation symposium in Copenhagen, Denmark in April 2013. The article reports on work from three well known and respected spokespeople within the following areas: latest recommendations for research based practice; the unique components of human milk; and the value of human milk in neonatal intensive care units.
Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-<i>α</i> and interferon-<i>γ</i>, and has potential in the treatment of arthritis (2003)

Evidence suggests that spironolactone, an aldosterone antagonist, has effects on many cell types independent of its binding to cytosolic mineralocorticoid receptors. We tested the effects of spironolactone on ex vivo-activated human blood leucocytes using gene expression analyses (GeneChip, 12,000 genes) and enzyme immunoassay for quantitating secreted pro- and anti-inflammatory cytokines. Furthermore, to evaluate the safety and efficacy of spironolactone as an anti-inflammatory drug 21 patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) or other arthritides were treated for up to 22 months with 1-3 mg/kg/day. Spironolactone, at in vivo attainable doses, markedly suppressed transcription of several proinflammatory cytokines and, accordingly, inhibited release of tumour necrosis factor, lymphotoxin, interferon-gamma, granulocyte-macrophage colony-stimulating factor and interleukin 6 (70-90% inhibition). Release of these cytokines was also suppressed when testing whole blood from RA patients receiving 50 mg spironolactone twice daily, indicating that pharmaceutical use of the drug may suppress the release of inflammatory cytokines. Spironolactone therapy was generally well tolerated, although treatment had to be stopped in two adults on concomitant methotrexate therapy. Sixteen patients (76%) responded favourably. American College of Rheumatology criteria (ACR)20 or better was achieved in six of nine RA patients; four reached ACR70. Eight of nine JIA patients improved. In conclusion, spironolactone inhibits production of several proinflammatory cytokines considered to be of pathogenic importance in many immunoinflammatory diseases and shows positive effect in patients with chronic arthritis. Its effect as an anti-inflammatory drug should be explored, because prolonged spironolactone therapy is reasonably safe and economically attractive compared with many modern anti-inflammatory therapies.