gebhart/patrepeval huggingface dataset:
Design and Implementation of Automated Clinical Whole Body Parametric PET With Continuous Bed Motion (2020)

We described workflows and methodologies for fully automated parametric imaging using clinical positron emission tomography (PET) systems with continuous bed motion (CBM) which aim to enable physicians to practice parametric PET routinely. The key components of our implemented methods include automatic generation of image-derived blood input functions, accurate tracking of slice imaging time during CBM acquisitions, and parametric image formation with advanced algorithms. Locations of the left ventricle and the descending aorta were automatically detected from high resolution anatomical images and registered to dynamic PET images to generate blood input functions. A method to accurately track dynamic scans and calculate time information for whole body CBM parametric PET was implemented based on bed position tags. This approach of calculating time information based on finely sampled bed position tags can be applied to flexible scan modes with various scan speeds over different body regions. We applied the calculated slice time information for whole body parametric imaging using a linear Patlak model. Parametric images were reconstructed with a nested expectation maximization (EM) algorithm. We demonstrated that parametric images generated by our automated workflow can provide quantitative parameters in addition to standardized uptake value images. We presented results for a uni-direction dynamic scan from a Biograph mCT system and a bi-direction dynamic scan from a Biograph Vision system.
HCV NS3/4a Protease Inhibitors: Simeprevir (TMC‐435350), Vaniprevir (MK‐7009) and MK‐5172 (2013)

Hepatitis C virus (HCV) infection continues to represent a major health issue, with estimates of 130–170 million people infected worldwide. Recent developments in the HCV NS3/4a protease inhibitor area have significantly improved treatment options for patients. However, a more dramatic paradigm shift in the treatment of HCV infection appears all but certain in coming years, with a move to all oral combination therapy with direct‐acting antivirals (DAAs). HCV protease inhibitors have the potential to play a significant role in these DAA combination therapies. This chapter discusses in detail the design and discovery of three HCV NS3/4a protease inhibitors in clinical development: simeprevir (TMC‐435350), vaniprevir (MK‐7009) and MK‐5172.
Production of functional human T-T hybridomas in selection medium lacking aminopterin and thymidine. (1982)

The production of hybridomas between immunologically activated T cells and malignant T-cell lines offers a potentially unlimited source of soluble T-cell-derived products. Recently, human T-T hybrids have been described; however, their use has been hampered by slow growth and chromosomal instability due at least in part to the presence of thymidine in the traditional hypoxanthine/aminopterin/thymidine (HAT) selection medium. In this report, we describe the development of a rapidly growing hypoxanthine phosphoribosyltransferase-deficient human T-cell line designated J3R7, the use of azaserine/hypoxanthine (AH) medium as an alternative selection medium to HAT medium, and the production of functional T-T hybrids by using the J3R7 line and the AH selection technique. Hybrids selected in AH medium were 4-fold greater in number and 3-fold faster in growth rate than hybrids grown in HAT medium. No stable clones were obtained from HAT cultures whereas AH-derived hybrids could be readily cloned by the method of limiting dilution. Evidence for hybridization included (i) the presence of approximately twice the number of chromosomes in hybrids than in J3R7 cells; (ii) the presence on hybrid cells of the Leu-3a surface antigen, present on normal helper T cells but not on J3R7 cells; (iii) the expression of HLA antigens of both the normal T-cell partner and the J3R7 line; and (iv) the constitutive secretion of interleukin 2 from multiple hybrid clones but not from the J3R7 cell line. Thus far, these clones have maintained their rapid growth, chromosome number, surface phenotype, and constitutive secretion of interleukin 2 for 4 months.
Raman fiber lasers as pumps for Raman amplification (2002)

This article describes Raman fiber lasers and their application as pumps to a Raman amplified optical communication system. Single wavelength, multiwavelength and dual-order devices are described. The advantages of Raman fiber lasers compared to semiconductor diodes are also discussed.
<title>Experimental demonstration of a chirp-modulated joint transfrom correlator using separate input SLMs</title> (1995)

The chirp encoded joint transform correlator (JTC) with separate input planes has been demonstrated in two experiments using Michaelson and Mach-Zehnder interferometers to combine the inputs. In the first, the Fourier plane modulation characteristics of the chirp- encoded JTC was investigated by correlating two pinholes. The peak-to-noise ratio performance in this experiment was 26 dB. In the second, chirp modulation was applied to correlating one fingerprint against a set of four fingerprints. Binary ferroelectric SLMs were used as inputs and for display in the Fourier plane. A discrimination ratio of 8.1 dB was demonstrated for the chirp modulated JTC. This is a 2.3 dB improvement over the discrimination observed using the same equipment in a binary JTC arrangement.
Vocal timbre analysis using latent Dirichlet allocation and cross-gender vocal timbre similarity (2014)

This paper presents a vocal timbre analysis method based on topic modeling using latent Dirichlet allocation (LDA). Although many works have focused on analyzing characteristics of singing voices, none have dealt with “latent” characteristics (topics) of vocal timbre, which are shared by multiple singing voices. In the work described in this paper, we first automatically extracted vocal timbre features from polyphonic musical audio signals including vocal sounds. The extracted features were used as observed data, and mixing weights of multiple topics were estimated by LDA. Finally, the semantics of each topic were visualized by using a word-cloud-based approach. Experimental results for a singer identification task using 36 songs sung by 12 singers showed that our method achieved a mean reciprocal rank of 0.86. We also proposed a method for estimating cross-gender vocal timbre similarity by generating pitch-shifted (frequency-warped) signals of every singing voice. Experimental results for a cross-gender singer retrieval task showed that our method discovered interesting similar pitch-shifted singers.
Ultrasound location and therapy method and apparatus for calculi in the body (1990)

First Page
Use of Ferrocene Scaffolds as Pendant Groups in Hairpin-Type Pyrrole-Imidazole Polyamide Molecules Showing Sequence-Selective Binding to DNA Duplexes (2005)

[reaction: see text] The synthesis and properties of new conjugate molecules, Fc-PIA, composed of ferrocene (Fc) and pyrrole-imidazole polyamides (PIA) are reported. As a PIA sequence, we chose Im-Py-Im/Py-Im-Py considering its future application to the SNPs detection of genes having a GCG/CGC sequence. Two types of Fc-containing linkers, i.e., ferrocene-1,1'-dicarboxamide and ferrocenecarboxamide, were designed, and several Fc-PIPA molecules having these linkers were synthesized. Titration studies by use of circular dichroism revealed that the carboxamide-type Fc-PIA could bind to the target DNA with an association constant of 10(7) M(-1). In contrast, ferrocene dicarboxamide-type compounds have slightly weaker affinity for the target DNA. However, the affinity could be recovered by replacing one of the pyrrole residues with beta-alanine. We carried out the CV measurement and observed quasi-irreversible oxidation of the ferrocene moieties in the Fc-PIA compounds. These properties of Fc-PIA indicate the potential usefulness of these molecules in electrochemical detection of genes.
Detection of rheumatoid arthritis-specific anti-filaggrin antibodies by line immunoassay shows complementarity to RF and corresponds to the AFA-blot using natural antigen (2001)

We discuss the presence of anti-keratin antibodies (AKA) of the IgG class in patients with defined juvenile idiopathic arthritis (JIA). An indirect immunofluorescence test and rat oesophagus substrate was used for the detection and quantification of AKA antibodies in patients sera. Overall 33/60 patients with JIA had sera positive for AKA (55 %, P = 0,0001) ranging from 1:10 to 1:160 dilutions. Following idiopathic arthritis of childhood classification criteria AKA occurred in 2/7 patients with systemic disease (28,6 %), in 13/30 patients with RF negative polyarthritis (43,3 %, P = 0,008) and in 15/18 RF positive polyarthritis (83,3 %, P = 0,000002). AKA were also found in a small cohort of patients with oligoarthritis (1/3) and psoriatic arthritis (2/2). AKA positivity occurred in 3/26 healthy controls at a 1:20 dilution. The presence of AKA was correlated as well as with the severity of the disease. Our study revealed that AKA was present overall in 18/29 patients (62%) with severe JIA and in 12/26 patients (46,2 %) with non-severe disease, however this did not reach statistical significance (P = 0,18). We also observed that AKA remained positive regardless of disease activity. AKA were detectable in 55,6 % patients with active JIA and in 48,6 % patients in the complete or near remission.
ChemInform Abstract: FACILE SYNTHESIS OF CODEINE FROM THEBAINE (1979)

Abstract Thebain (I) liefert bei Behandlung mit Hg(II)‐acetat, HCl und Boranat im Eintopfverfahren glatt Codein (II).
Atrial Natriuretic Peptide Induces Natriuretic Peptide Receptor-cGMP-dependent Protein Kinase Interaction (2003)

Circulating natriuretic peptides such as atrial natriuretic peptide (ANP) counterbalance the effects of hypertension and inhibit cardiac hypertrophy by activating cGMP-dependent protein kinase (PKG). Natriuretic peptide binding to type I receptors (NPRA and NPRB) activates their intrinsic guanylyl cyclase activity, resulting in a rapid increase in cytosolic cGMP that subsequently activates PKG. Phosphorylation of the receptor by an unknown serine/threonine kinase is required before ligand binding can activate the cyclase. While searching for downstream PKG partners using a yeast two-hybrid screen of a human heart cDNA library, we unexpectedly found an upstream association with NPRA. PKG is a serine/threonine kinase capable of phosphorylating NPRA in vitro; however, regulation of NPRA by PKG has not been previously reported. Here we show that PKG is recruited to the plasma membrane following ANP treatment, an effect that can be blocked by pharmacological inhibition of PKG activation. Furthermore, PKG participates in a ligand-dependent gain-of-function loop that significantly increases the intrinsic cyclase activity of the receptor. PKG translocation is ANP-dependent but not nitric oxide-dependent. Our results suggest that anchoring of PKG to NPRA is a key event after ligand binding that determines distal effects. As such, the NPRA-PKG association may represent a novel mechanism for compartmentation of cGMP-mediated signaling and regulation of receptor sensitivity.
Integrated Fluxgate Magnetometer for Use in Isolated Current Sensing (2016)

This paper presents two integrated magnetic sensor ICs for isolated current measurement that have a fluxgate magnetometer co-integrated along with circuitry on a die. The integrated fluxgate has a sensitivity of 250 V/T and a 500 ksps readout circuit and requires only 5.4 mW for fluxgate excitation, which is 20x more power-efficient than the state of the art. The fluxgate magnetometer was used to realize the first fully integrated sensor IC for closed-loop current sensing. It achieves a dynamic range of 112 dB and a nonlinearity below 0.03%. A second realization provides a precision magnetic sensor IC that can be used for open-loop and differential-field current sensing. It features a sensor gain variation of 0.04% (1-sigma), a nonlinearity below 0.2%, a bandwidth of 47 kHz, and a dynamic range of 100 dB.
AN IMPROVED SYNTHESIS OF 9-[2-(DIETHOXYPHOSPHONOMETHOXY)ETHYL]ADENINE AND ITS ANALOGUES WITH OTHER PURINE BASES UTILIZING THE MITSUNOBU REACTION (1996)

Abstract Unprotected adenine, 6-chloropurine, 2.6-diaminopurine. and 2-amino-6-chluropurine have been directly coupled with 2-(diethoxyphosphonomethoxy)ethanol under Mitsunobu reaction conditions to provide acyclic phosphonate nucleotide analogues which are intermediates for antiviral agents such as PMEA.
Signaling Enhancement for Machine Type Communications in GERAN Using Orthogonal Sub-Channels (2011)

Machine type communications have emerged with new types of applications and revenue sources both for network operators and cellular/network equipment companies. This new kind of service may increase significantly the number of devices accessing the network in the next few years, and could have some impacts over the current services, namely normal voice and data services. One important concern is related to effects of extreme cases where MTC devices may act in a synchronized way. In GSM networks, the signaling capacity may be temporarily blocked, limiting the access of normal services for some seconds, or even minutes. This paper proposes one solution for overload problem caused by MTC device synchronization using the Orthogonal sub- channels technique (OSC). Statistical analysis over the effects of synchronized MTC devices are used to provide an overview on the achievable access procedure delay reduction when using this technique. The proposed technique has proven to decrease the average delay of normal services by 70% and to reduce by 50% the overload period of the signaling channels.
Human antibodies for immunotherapy development generated via a human B‐cell hybridoma technology (2006)

Current strategies for the production of therapeutic MAbs include the use of mammalian cell systems to recombinantly produce antibodies derived from mice bearing human immunoglobulin transgenes, humanization of rodent antibodies, or phage libraries. We have previously reported the use of transient regulation of cellular DNA mismatch repair processes to enhance traits (e.g. affinity, titers) of MAb‐producing cell lines, including hybridomas. We reasoned that this process, named morphogenics, could be utilized to improve suboptimal hybridoma cells generated via ex‐vivo immunization and immortalization of antigen‐specific human B‐cells for therapeutic antibodies development. Here we present a platform process that combines hybridoma and morphogenics technologies for the generation of fully human MAbs specific for disease‐associated human antigens. We were able to generate hybridoma lines secreting MAbs with high binding specificity and biological activity. One MAb with strong neutralizing activity against human GM‐CSF was identified that is currently advanced to preclinical development for autoimmune disease indications. Moreover, these hybridoma cells have proven suitable for genetic optimization using the morphogenics process and have shown potential for large scale manufacturing.
Water-Based Drilling Fluid for HP/HT Applications (2007)

Water-Based Drilling Fluid for HT/HP Applications M. A. Tehrani; M. A. Tehrani M-I Swaco Search for other works by this author on: This Site Google Scholar A. Popplestone; A. Popplestone M-I Swaco Search for other works by this author on: This Site Google Scholar A. Guarneri; A. Guarneri Eni E&P Search for other works by this author on: This Site Google Scholar S. Carminati S. Carminati Eni E&P Search for other works by this author on: This Site Google Scholar Paper presented at the International Symposium on Oilfield Chemistry, Houston, Texas, U.S.A., February 2007. Paper Number: SPE-105485-MS https://doi.org/10.2118/105485-MS Published: February 28 2007 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Tehrani, M. A., Popplestone, A., Guarneri, A., and S. Carminati. "Water-Based Drilling Fluid for HT/HP Applications." Paper presented at the International Symposium on Oilfield Chemistry, Houston, Texas, U.S.A., February 2007. doi: https://doi.org/10.2118/105485-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE International Conference on Oilfield Chemistry Search Advanced Search Abstract The superior performance of invert emulsion fluids in challenging drilling operations such as HT/HP wells makes them the preferred fluid for such applications. However, there are instances such as drilling in environmentally sensitive areas, or where costs and logistics become prohibitive, where their use is undesirable. In such circumstances, a high-performance water-based drilling fluid is the only option available. A main challenge in developing a water-based fluid for such applications has been to maintain the stability of key fluid properties such as rheology and fluid loss at temperatures in excess of 130°C. Conventional additives, such as biopolymers or synthetic polymers, either become ineffective at such high temperatures or generate too high a rheology when used in quantities needed to curb fluid loss. This paper discusses a novel water-based drilling fluid system in which the synergy of the key fluid components produces a stable rheology and low fluid loss at temperatures approaching 200°C. Furthermore, by balancing the components of the novel system, fluid rheology can be controlled to meet the hydraulics and hole-cleaning demands of the drilling operation.1, 2 Keywords: drilling fluid chemistry, drilling fluid formulation, polymer, fluid loss, drilling fluids and materials, nonionic polymer, weight material, water-based drilling fluid, anionic polymer, drilling fluid selection and formulation Subjects: Drilling Fluids and Materials, Drilling fluid selection and formulation (chemistry, properties), Drilling fluid management & disposal Copyright 2007, Society of Petroleum Engineers You can access this article if you purchase or spend a download.
Silica Embedded Metal Hydrides (1998)

A method to produce silica embedded metal hydride was developed. The product is a composite in which metal hydride particles are embedded in a matrix of silica. The silica matrix is highly porous. Hydrogen gas can easily reach the embedded metal hydride particles. The pores are small so that the metal hydride particles cannot leave the matrix. The porous matrix also protects the metal hydride particles from larger and reactive molecules such as oxygen, since the larger gas molecules cannot pass through the small pores easily. Tests show that granules of this composite can absorb hydrogen readily and withstand many cycles without making fines.
CUSP: A 2-μm CMOS Digital Signal Processor (1985)

This paper describes the Cornell University Signal Processor (CUSP), a 60 000 transistor 2-/spl mu/m CMOS processor custom designed to compute the Fast Fourier Transform (FFT) and related algorithms. Operating on a 50-MHz clock, the bit-serial arithmetic hardware on a CUSP chip performs over 15 million 20 X 20 bit multiplications per second and computes a 1024 point FFT in 1.33 ms. The chip architecture is presented along with a description of the arithmetic, control, and fault detection circuitry. The inclusion of these components on a single chip is shown to allow large fault tolerant arrays of CUSP processors to be efficiently employed for high-performance applications.
Lactobacillus johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats (2010)

It was determined that the administration of L. johnsonii isolated from BioBreeding diabetes resistant rats delays or inhibits the onset of type 1 diabetes in BioBreeding diabetes prone rats. Taken collectively, these data suggest that the gut and the gut microbiota are potential agents of influence in type 1 diabetes development. These data also support therapeutic efforts that seek to modify gut microbiota as a means to modulate development of this disorder.
JCCap: Capability-Based Access Control for Java Card (2000)

This paper describes JCCap, a protection facility for cooperating applications in the context of Java Card. It enables the control of access rights between mutually suspicious applications, either between one terminal application and one Java Card applet or between two applets hosted inside the same Java Card. Using JCCap, access to objects is controlled by means of software capabilities that can be exchanged between mutually suspicious applications. An important advantage of JCCap is that the definition of the protection policy of an application (i.e., how access rights are granted to other applications) is completely separated from the application code. The protection policy is described in an extended Interface Definition Language (IDL) at the interface level, thus enhancing modularity, separation of concerns, and ease of expression in the design of the overall security architecture Each application can define its own protection policy independently from the other applications, thus enabling the expression of mutual suspicion without any prior knowledge about the policies of other applications. Every protection policy is then applied when applications interact with each other. This paper describes the implementation of a prototype of JCCap. It shows the feasibility and applicability of this technique in today’s Java Card and outline its advantages.
Use of a Metal-Nitride-Oxide-Semiconductor as the Detector for a Radiation Dosimeter (1978)

A method of radiation dosimetry using a Metal-Nitride-Oxide-Semiconductor (MNOS) transitor as the detector was developed and partially evaluated. An MNOS dosimeter is shown capable of measuring doses from 10 k rads to 4 M rads. The measured electrical characteristics of the MNOS transitor, which are altered by ionizing radiation, can be electrically reset to their pre-irradiation values. Repeatability of observations of threshold voltage versus radiation dosage indicates a precision of ± 1% of measured dose from 200 k rads to 4 M rads (Si). Dosage in rads is obtained by reference to a calibrated Co60 source exposure rate rather than to absorbed dose in the dosimeter. A schematic is given for the circuit tested. Determination of dosage with the system is indirect and requires the use of calibration curves. Each dosimeter must be individually calibrated. Exposure to 2 × 107 rads did not degrade performance. The MNOS transistors eventually failed: probably due to charge migration from the large integrated circuit chip on which they were fabricated. Discrete, non-stepped gage MNOS transistors are recommended.
Critical area computation for missing material defects in VLSI circuits (2000)

We address the problem of computing critical area for missing material defects in a circuit layout. The extraction of critical area is the main computational problem in VLSI yield prediction. Missing material defects cause open circuits and are classi ed into breaks and via-blocks. Our approach is based on the L1 medial axis of polygons and the weighted L1 Voronoi diagram of segments. The critical area problem for both breaks and via-blocks is reduced to a weighted L1 Voronoi diagram of segments. This reduction results in a plane sweep algorithm to compute critical area in one pass. The time complexity i s O(n log n) in the case of breaks and O(n log n + K) in the case of via-blocks, where n is the size of the input and K is bounded by the number of interacting vias (in practice K is small). The critical area computation assumes square defects and re ects all possible defect sizes following the D(r) = r 2 0 =r 3 defect size distribution. The method is presented for rectilinear layouts.