gebhart/patrepeval huggingface dataset:
Intracellular Electrolytes and Hormonal Parameters during Weight Reduction (1984)

The mechanisms of the blood pressure lowering effect of weight reduction have not yet been fully elucidated. In this study the intracellular electrolyte composition and hormonal parameters were monitored in 12 obese subjects during a 10-day diet with 800 kcal/day. A decrease in intracellular free Na+ (p less than 0.05) and Mg2+ (p less than 0.01) and in total intracellular K+ (p less than 0.05) was observed. Furthermore, plasma aldosterone and renin activity (p less than 0.05) increased, probably due to a moderate simultaneous salt restriction. There was also an increase in plasma PGI2 concentration (p less than 0.05). The observed decrease in intracellular free Na+ may be caused by salt restriction. The decrease in intracellular K+ and free Mg2+ may be induced by hormonal factors, e.g. an altered insulin secretion. Possible causes for the known hemodynamic effects of weight reduction are the diminution of intracellular Na+ and the increase in plasma PGI2.
PRE-render Content Using Tiles (PRECUT). 1. Large-Scale Compound-Target Relationship Analyses (2017)

Visualizing a complex network is computationally intensive process and depends heavily on the number of components in the network. One way to solve this problem is not to render the network in real time. PRE-render Content Using Tiles (PRECUT) is a process to convert any complex network into a pre-rendered network. Tiles are generated from pre-rendered images at different zoom levels, and navigating the network simply becomes delivering relevant tiles. PRECUT is exemplified by performing large-scale compound-target relationship analyses. Matched molecular pair (MMP) networks were created using compounds and the target class description found in the ChEMBL database. To visualize MMP networks, the MMP network viewer has been implemented in COMBINE and as a web application, hosted at http://cheminformatic.com/mmpnet/.
Striking Differences between the Solution and Solid-State Reactivity of Iron PNP Pincer Complexes with Carbon Monoxide (2009)

Several new iron(II) complexes of the types [Fe(PNP)X2] (X = Cl, Br) containing tridentate PNP pincer-type ligands based on 2,6-diaminopyridine and 2,6-diaminopyrimidine have been prepared. They all exhibit intermolecular Fe−X···H−N hydrogen bonds, forming supramolecular networks in the solid state. In the case of X = Cl these compounds react readily with gaseous CO both in the solid state and in solution to give selectively the octahedral complexes cis- and trans-[Fe(PNP)(CO)(Cl)2], respectively, whereas with X = Br mixtures of cis and trans isomers are obtained. These transformations are accompanied by color and spin-state changes. CO binding is fully reversible in all cases, and heating solid samples of either cis- or trans-[Fe(PNP)(CO)(X)2] leads to complete regeneration of analytically pure [Fe(PNP)(X)2]. Mössbauer spectroscopy confirmed the high-spin nature of the parent five-coordinate Fe(II) complex (δ = 0.80(1) mm s−1) and the shift to two different low-spin octahedral species after reaction with CO in the solid (δ = 0.13(1) mm s−1) or in solution (δ = 0.15(1) mm s−1). Magnetization studies led to a magnetic moment close to 4.9 μB, reflecting the expected four unpaired d-electrons in [Fe(PNP)Cl2], which were confirmed by DFT calculations. The DFT study of the reaction pathway for CO capture led to low energy barriers (≤3.4 kcal mol−1). The cis−trans isomerization reaction was found to take place with a low energy barrier (10.8 kcal mol−1), after initial loss of chloride, and involves also spin-state changes
The Technology of the ZF CVT - CFT 23 (2001)

<div class="htmlview paragraph">Continuously variable automatic transmissions with belt-type variator are gaining increasing significance, most especially in front-transverse installations. Their favorable fuel consumption levels, increased comfort and wider ratio ranges in comparison with multi-ratio automatic transmissions make them ideal components for the modern driveline.</div> <div class="htmlview paragraph">The continuously variable ratio adjustment provides significant advantages. However from a technical development standpoint, increasing the (design-based) mechanical efficiency and optimizing co-ordination with the engine represent the greatest challenge and a significant potential for further development.</div>
Band Structure and Fermi Surface of Electron-Doped C <sub>60</sub> Monolayers (2003)

C60 fullerides are challenging systems because both the electron-phonon and electron-electron interactions are large on the energy scale of the expected narrow band width. We report angle-resolved photoemission data on the band dispersion for an alkali-doped C60 monolayer and a detailed comparison with theory. Compared to the maximum bare theoretical band width of 170 meV, the observed 100-meV dispersion is within the range of renormalization by electron-phonon coupling. This dispersion is only a fraction of the integrated peak width, revealing the importance of many-body effects. Additionally, measurements on the Fermi surface indicate the robustness of the Luttinger theorem even for materials with strong interactions.
Improving emission uniformity and linearizing band dispersion in nanowire arrays using quasi-aperiodicity (2017)

For this study, we experimentally investigate a new class of quasi-aperiodic structures for improving the emission pattern in nanowire arrays. Efficient normal emission, as well as lasing, can be obtained from III-nitride photonic crystal (PhC) nanowire arrays that utilize slow group velocity modes near the Γ-point in reciprocal space. However, due to symmetry considerations, the emitted far-field pattern of such modes are often ‘donut’-like. Many applications, including lighting for displays or lasers, require a more uniform beam profile in the far-field. Previous work has improved far-field beam uniformity of uncoupled modes by changing the shape of the emitting structure. However, in nanowire systems, the shape of nanowires cannot always be arbitrarily changed due to growth or etch considerations. Here, we investigate breaking symmetry by instead changing the position of emitters. Using a quasi-aperiodic geometry, which changes the emitter position within a photonic crystal supercell (2x2), we are able to linearize the photonic bandstructure near the Γ-point and greatly improve emitted far-field uniformity. We realize the III-nitride nanowires structures using a top-down fabrication procedure that produces nanowires with smooth, vertical sidewalls. Comparison of room-temperature micro-photoluminescence (µ-PL) measurements between periodic and quasi-aperiodic nanowire arrays reveal resonances in each structure, with the simple periodic structure producing a donut beam in the emitted far-field and the quasi-aperiodic structure producing a uniform Gaussian-like beam. We investigate the input pump power vs. output intensity in both systems and observe the simple periodic array exhibiting a non-linear relationship, indicative of lasing. We believe that the quasi-aperiodic approach studied here provides an alternate and promising strategy for shaping the emission pattern of nanoemitter systems.
Analytical Reviews in Clinical Biochemistry: The Estimation of Creatinine (1986)

PHYSIOLOGY Creatine is synthesised by the body in a two-step process (Fig. 1) involving the initial synthesis of guanidinoacetate, which takes place in the kidneys, small intestinal mucosa, pancreas, and probably the liver. The reaction between glycine and arginine is catalysed by a transamidase, which is subject to feedback inhibition by increased creatine levels. Guanidinoacetate is transported to the liver where it is methylated to creatine, which then enters the blood to be widely distributed, chiefly to muscle cells, in which it is converted to creatine phosphate-a source of high energy phosphate bonds for the immediate reformation of ATP during muscular contraction. Creatinine is formed by a spontaneous and irreversible conversion from creatine and creatine phosphate. Formation of creatinine is reasonably constant, and about 2% of whole body creatine is so transformed every 24 h. Consequently, creatinine formation also has a direct relationship to total muscle mass and roughly to the body weight. Creatinine production rate therefore remains approximately the same from day to day unless the muscle mass changes. It is not altered significantly by illness, sepsis, trauma or fever, nor by the state of hydration; however, increased protein intake can result in increases in creatinine production of the order of 10%.
Characterization of Insertion Loss and Back Reflection in Passive Hybrid Silicon Tapers (2013)

The optical properties of two hybrid silicon taper designs are investigated. These tapers convert the optical mode from a silicon waveguide to a hybrid silicon III/V waveguide. A passive chip was fabricated with an epitaxial layer similar to those used in hybrid silicon lasers. To separate optical scattering and mode mismatch from quantum-well absorption, the active layer in this paper was designed to be at 1410 nm, to allow measurements at 1550 nm. Using cutback structures, the taper loss and the taper reflection are quantified. Taper losses between 0.2 and 0.6 dB per taper and reflections below -41 dB are measured.
Regional Lung Deposition and Bronchodilator Response as a Function of β2-Agonist Particle Size (2005)

Regional targeting of inhaled beta2-agonist to the proximal airways is more important than distal alveolar deposition for bronchodilation. Altering intrapulmonary deposition through aerosol particle size can appreciably enhance inhaled drug therapy and may have implications for developing future inhaled treatments.
Rapid Diagnosis of Avian Influenza Virus in Wild Birds: Use of a Portable rRT-PCR and Freeze-dried Reagents in the Field (2011)

Wild birds have been implicated in the spread of highly pathogenic avian influenza (HPAI) of the H5N1 subtype, prompting surveillance along migratory flyways. Sampling of wild birds for avian influenza virus (AIV) is often conducted in remote regions, but results are often delayed because of the need to transport samples to a laboratory equipped for molecular testing. Real-time reverse transcriptase polymerase chain reaction (rRT-PCR) is a molecular technique that offers one of the most accurate and sensitive methods for diagnosis of AIV. The previously strict lab protocols needed for rRT-PCR are now being adapted for the field. Development of freeze-dried (lyophilized) reagents that do not require cold chain, with sensitivity at the level of wet reagents has brought on-site remote testing to a practical goal. Here we present a method for the rapid diagnosis of AIV in wild birds using an rRT-PCR unit (Ruggedized Advanced Pathogen Identification Device or RAPID, Idaho Technologies, Salt Lake City, UT) that employs lyophilized reagents (Influenza A Target 1 Taqman; ASAY-ASY-0109, Idaho Technologies). The reagents contain all of the necessary components for testing at appropriate concentrations in a single tube: primers, probes, enzymes, buffers and internal positive controls, eliminating errors associated with improper storage or handling of wet reagents. The portable unit performs a screen for Influenza A by targeting the matrix gene and yields results in 2-3 hours. Genetic subtyping is also possible with H5 and H7 primer sets that target the hemagglutinin gene. The system is suitable for use on cloacal and oropharyngeal samples collected from wild birds, as demonstrated here on the migratory shorebird species, the western sandpiper (Calidrus mauri) captured in Northern California. Animal handling followed protocols approved by the Animal Care and Use Committee of the U.S. Geological Survey Western Ecological Research Center and permits of the U.S. Geological Survey Bird Banding Laboratory. The primary advantage of this technique is to expedite diagnosis of wild birds, increasing the chances of containing an outbreak in a remote location. On-site diagnosis would also prove useful for identifying and studying infected individuals in wild populations. The opportunity to collect information on host biology (immunological and physiological response to infection) and spatial ecology (migratory performance of infected birds) will provide insights into the extent to which wild birds can act as vectors for AIV over long distances.
Principles into practice the development of a pastoral care system in an emergent comprehensive (1973)

"Principles into practice the development of a pastoral care system in an emergent comprehensive." Learning for Living, 12(3), pp. 24–25
Mouse models for BRCA1-associated breast cancer (2003)

The remarkable generation of scores of increasingly sophisticated mouse models of mammary cancer over the past two decades has provided tremendous insights into molecular derangements that can lead to cancer. The relationships of these models to human breast cancer, however, remain problematic. Recent advances in genomic technologies offer significant opportunities to identify critical changes that occur during cancer evolution and to distinguish in a complex and comprehensive manner the key similarities and differences between mouse models and human cancer. Comparisons between mouse and human tumors are being performed using comparative genomic hybridization, gene expression profiling, and proteomic analyses. The appropriate use of genetically engineered mouse models of mammary cancer in preclinical studies remains an important challenge which may also be aided by genomic technologies. Genomic approaches to cancer are generating huge datasets that represent a complex system of underlying networks of genetic interactions. Mouse models offer a tremendous opportunity to identify such networks and how they relate to human cancer. The challenge of the future remains to decipher these networks in order to identify the genetic nodes of oncogenesis that may be important targets for chemoprevention and therapy.
Augmentation of leukocyte infiltration in murine tumors expressing B-cell derived but not nasopharyngeal carcinoma derived EBV membrane protein LMP1 (2000)

The Epstein-Barr virus (EBV) encoded latent membrane protein of B cell origin, B-LMP1 (B95-8 prototype) and nasopharyngeal carcinoma (NPC) derived C-LMP1 (CAO prototype) were transfected individually in S6C adenocarcinoma cells of ACA (H-2f) origin. We have shown previously that inoculation of B-LMP1 expressing S6C cells led to tumor rejection in pre-immunized, immunocompetent syngeneic ACA mice, whereas the C-LMP1 transfectants were not immunogenic. Furthermore, B-LMP1 but not C-LMP1 expressing S6C cells grew with necrosis and extensive skin damage in non-immunized mice. A study was carried out to determine whether the in vivo growth pattern of S6C cells expressing two different LMP1 isolates could be correlated to any immunomodulatory mechanism. An increased infiltration of CD45+ leukocytes was found in B-LMP1 expressing S6C tumors originating in non-immunized, syngeneic ACA mice. The C-LMP1 expressors, vector transfectants and untransfected parental tumors had significantly lower number of infiltrating leukocytes. The immunoaccessory molecules ICAM-1, B7-1 and MHC Class I and II expression was unaltered in both B- and C-LMP1 transfectants. The data suggest that B-LMP1 but not C-LMP1 induce anti-tumor immune response. J. Med. Virol. 60:417–424, 2000. © 2000 Wiley-Liss, Inc.
An Anti-Phospholipase A2 Receptor Quantitative Immunoassay and Epitope Analysis in Membranous Nephropathy Reveals Different Antigenic Domains of the Receptor (2013)

The phospholipase A2 receptor (PLA2R) was recently discovered as a target autoantigen in patients with idiopathic membranous nephropathy (IMN). Published evidence suggests that the autoantibodies directed towards a conformation dependent epitope are currently effectively detected by a cell based assay (CBA) utilizing indirect immunofluorescence (IIF) on tissue culture cells transfected with the PLA2R cDNA. Limitations of such IIF-CBA assays include observer dependent subjective evaluation of semi-quantitative test results and the protocols are not amenable to high throughput diagnostic testing. We developed a quantitative, observer independent, high throughput capture immunoassay for detecting PLA2R autoantibodies on an addressable laser bead immunoassay (ALBIA) platform. Since reactive domains of PLA2R (i.e. epitopes) could be used to improve diagnostic tests by using small peptides in various high throughput diagnostic platforms, we identified PLA2R epitopes that bound autoantibodies of IMN patients. These studies confirmed that inter-molecular epitope spreading occurs in IMN but use of the cognate synthetic peptides in immunoassays was unable to conclusively distinguish between IMN patients and normal controls. However, combinations of these peptides were able to effectively absorb anti-PLA2R reactivity in IIF-CBA and an immunoassay that employed a lysate derived from HEK cells tranfected with and overexpressing PLA2R. While we provide evidence of intermolecular epitope spreading, our data indicates that in addition to conformational epitopes, human anti-PLA2R reactivity in a commercially available CBA and an addressable laser bead immunoassay is significantly absorbed by peptides representing epitopes of PLA2R.
Efficient decoupling schemes with bounded controls based on Eulerian orthogonal arrays (2006)

The task of decoupling, i.e., removing unwanted internal couplings of a quantum system and its couplings to an environment, plays an important role in quantum control theory. There are many efficient decoupling schemes based on combinatorial concepts such as orthogonal arrays, difference schemes, and Hadamard matrices. So far these combinatorial decoupling schemes have relied on the ability to effect sequences of instantaneous, arbitrarily strong control Hamiltonians (bang-bang controls). To overcome the shortcomings of bang-bang control, Viola and Knill proposed a method called ``Eulerian decoupling'' that allows the use of bounded-strength controls for decoupling. However, their method was not directly designed to take advantage of the local structure of internal couplings and couplings to an environment that typically occur in multipartite quantum systems. In this paper we define a combinatorial structure called Eulerian orthogonal array. It merges the desirable properties of orthogonal arrays and Eulerian cycles in Cayley graphs (that are the basis of Eulerian decoupling). We show that this structure gives rise to decoupling schemes with bounded-strength control Hamiltonians that can be used to remove both internal couplings and couplings to an environment of a multipartite quantum system. Furthermore, we show how to construct Eulerian orthogonal arrays having good parameters in order to obtain efficient decoupling schemes.
Regulation of Retinal and Optic Nerve Blood Flow (1998)

Blood flow to the retina and optic nerve remains constant over a range of elevated intraocular pressure or mean arterial pressure, independent of sympathetic activation (pressure autoregulation). In addition, increased metabolic activity in these tissues proportionally increases blood flow (metabolic autoregulation). At constant metabolic rate, altered arterial oxygen content reciprocally alters blood flow, leaving total oxygen delivery constant, while blood flow rises and falls with the arterial carbon dioxide tension. These responses are similar to those of the cerebral circulation. However, while aging, atherosclerosis, arterial hypotension, and individual variation may profoundly alter blood flow regulation and predispose to the development of illness, these factors remain largely unexplored.
Palladium-Catalyzed Azathiolation of Carbon Monoxide (1999)

A novel palladium-catalyzed azathiolation of carbon monoxide using sulfenamide (RSNR‘2) (1) is described to provide thiocarbamate 2 in good yields. The mechanistic proposal includes the following: (1) insertion of CO into Pd−S bond of Pd(SR)2(PPh3)n 4 to provide Pd[C(O)SR](SR)(PPh3)n 5 and (2) σ-bond metathesis between S−N and Pd−C(O) bonds to afford 2 with the regeneration of 4.
Analysis of a very large trinucleotide repeat in a patient with juvenile Huntington’s disease (1999)

A patient with juvenile Huntington's disease (HD) of probable maternal inheritance is reported. The expanded IT-15 allele was only detected with the use of modified PCR and Southern transfer techniques, which showed a CAG trinucleotide repeat expansion of approximately 250 repeats-the largest CAG expansion reported within the huntingtin gene. This case emphasizes the need for communication between the diagnostic laboratory and the clinician to define the molecular genetics of unusual cases.
A Comparative Analysis of In-house and Outsourced Development in Software Industry (2016)

These days, many software companies handover their software projects to outsourcing organizations. Outsourcing refers to handing over some or complete business process activities to some outside manufacturer. Many software companies now have started feeling the need of outsource development due to numerous factors that include high cost of experienced in-house developers, tough project schedules, lack of knowledge about domain and technology of certain complex software systems. Outsourcing is causing globalization, knowledge sharing, achieving quality and minimizing production cost. Software project outsourcing is common in many software companies, this makes it an active and interesting research area. This paper investigates the current state of the art in software project outsourcing. An effort has been made to answer an important question about outsourcing “Is software outsourcing a gain or loss?” A detailed comparison of in-house software development and outsourced software development has been conducted to show when and where outsourcing is useful for an organization and where it is not.
<title>Design of a piezoelectric inchworm actuator and compliant end effector for minimally invasive surgery</title> (1999)

Recent advances in robotics, tele-robotics, smart material actuators, and mechatronics raise new possibilities for innovative developments in millimeter-scale robotics capable of manipulating objects only fractions of a millimeter in size. These advances can have a wide range of applications in the biomedical community. A potential application of this technology is in minimally invasive surgery (MIS). The focus of this paper is the development of a single degree of freedom prototype to demonstrate the viability of smart materials, force feedback and compliant mechanisms for minimally invasive surgery. The prototype is a compliant gripper that is 7-mm by 17-mm, made from a single piece of titanium that is designed to function as a needle driver for small scale suturing. A custom designed piezoelectric `inchworm' actuator drives the gripper. The integrated system is computer controlled providing a user interface device capable of force feedback. The design methodology described draws from recent advances in three emerging fields in engineering: design of innovative tools for MIS, design of compliant mechanisms, and design of smart materials and actuators. The focus of this paper is on the design of a millimeter-scale inchworm actuator for use with a compliant end effector in MIS.
A raster-output 2D MEMS scanner with an 8 &#x00D7; 4 mm mirror for an automotive time-of-flight image sensor (2013)

We present a moving-magnet type raster-output 2D MEMS scanner with a large mirror. The mirror has resonance frequencies above 300 Hz to provide a high tolerance against automobile vibrations. To drive large mirrors, high driving torques are required. Electromagnets with tapered magnetic poles were used, which generated concentrated magnetic fields near a moving magnet. The fabricated MEMS scanner was 17×14×25 mm in size and achieved full mechanical rotation angles (FMRAs) of 10° in a non-resonance mode and 7° in a resonance mode.