gebhart/patrepeval huggingface dataset:
Mig-6 controls EGFR trafficking and suppresses gliomagenesis (2010)

Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer that is driven by aberrant signaling of growth factor receptors, particularly the epidermal growth factor receptor (EGFR). EGFR signaling is tightly regulated by receptor endocytosis and lysosome-mediated degradation, although the molecular mechanisms governing such regulation, particularly in the context of cancer, remain poorly delineated. Here, high-resolution genomic profiles of GBM identified a highly recurrent focal 1p36 deletion encompassing the putative tumor suppressor gene, Mig-6. We show that Mig-6 quells the malignant potential of GBM cells and dampens EGFR signaling by driving EGFR into late endosomes and lysosome-mediated degradation upon ligand stimulation. Mechanistically, this effect is mediated by the binding of Mig-6 to a SNARE protein STX8, a protein known to be required for late endosome trafficking. Thus, Mig-6 functions to ensure recruitment of internalized receptor to late endosomes and subsequently the lysosomal degradation compartment through its ability to specifically link EGFR and STX8 during ligand-stimulated EGFR trafficking. In GBM, the highly frequent loss of Mig-6 would therefore serve to sustain aberrant EGFR-mediated oncogenic signaling. Together, these data uncover a unique tumor suppression mechanism involving the regulation of receptor trafficking.
Superior efficacy of calcipotriene and betamethasone dipropionate aerosol foam versus ointment in patients with psoriasis vulgaris – A randomized phase II study (2015)

Cal/BD aerosol foam demonstrates significantly greater efficacy and similar tolerability compared with Cal/BD ointment for psoriasis treatment.
Molecular evolution of lycopene cyclases involved in the formation of carotenoids with ionone end groups (2000)

A survey is given of the lycopene cyclase genes present in bacteria, fungi and plants where two completely unrelated types exist. One is the classical monomeric bacterial beta-cyclase gene, crtY, which may be an ancestor of crtL, the gene for a beta-cyclase in cyanobacteria. From crtL a line of evolution can be drawn to plant beta- and epsilon-cyclase genes and to the gene of capsanthin/capsorubin synthase. In Gram-positive bacteria two genes crtYc and crtYd are present. They encode two proteins which have to interact as a heterodimer for lycopene beta-cyclization. From this type of lycopene cyclase gene the fungal lycopene cyclase/phytoene synthase fusion gene evolved.
Dissipative soliton resonance mode-locked all-polarization-maintaining double clad Er:Yb fiber laser (2017)

Our first demonstration of an all-PM fiber double clad erbium-ytterbium figure-8 laser mode-locked in a dissipative soliton resonance regime is presented. The laser generated µJ-level rectangular-shaped pulses with a maximum average output power of 1 W at 994 kHz repetition rate. The proposed configuration was characterized for two values resonator lengths - 44 and 205 m (total net-dispersion -0.9274 ps<sup>2</sup> and -4.3084 ps<sup>2</sup>, respectively) to verify the possibility of non-complex tailoring of pulse parameters. The long-term stability of the all-PM configuration and self-starting of the mode-locking was experimentally confirmed by exposing the laser to forces of -5G to 7G magnitude on a vibration generator.
Space-Time Signal Processing for Distributed Pattern Detection in Sensor Networks (2013)

A theory and algorithm for detecting and classifying weak, distributed patterns in network data is presented. The patterns we consider are anomalous temporal correlations between signals recorded at sensor nodes in a network. We use robust matrix completion and second order analysis to detect distributed patterns that are not discernible at the level of individual sensors. When viewed independently, the data at each node cannot provide a definitive determination of the underlying pattern, but when fused with data from across the network the relevant patterns emerge. We are specifically interested in detecting weak patterns in computer networks where the nodes (terminals, routers, servers, etc.) are sensors that provide measurements (of packet rates, user activity, central processing unit usage, etc.). The approach is applicable to many other types of sensor networks including wireless networks, mobile sensor networks, and social networks where correlated phenomena are of interest.
A Dolph-Chebyshev approach to the synthesis of array patterns for uniform circular arrays (2000)

Uniform circular arrays (UCAs) are naturally suited to provide 360 degrees of coverage in the azimuthal plane. In this paper, we describe a new approach for synthesizing array patterns with guaranteed maximum sidelobe levels for any look direction. The advantage of this approach is that it is computationally efficient which makes it eminently suitable for real-time beamforming and beamsteering applications. The approach is based on the Dolph-Chebyshev method for uniform linear arrays except here, the Dolph-Chebyshev method is applied to the transformed array response vector of the UCAs.
Surface Reaction Film Formation by Si2 H 6 Transfer at Molecular Flow (1989)

High‐rate silicon epitaxial growth of 1.1 μm/min has been achieved at a substrate temperature of 750°C by using a new source gas supply system, such as a free‐jet molecular flow expanding into ultra‐high vacuum. Film formation is thought to be carried out by the surface reaction of adsorbed source gas molecules, without production of microparticles by any accompanying vapor phase reaction, which would degrade film qualities. It was found that the effect of electron‐hole excitation in the substrate with a xenon lamp is also involved in the high‐rate growth. The newly developed system is cleaning‐free, because there is no deposition of reaction by‐products on the inner surface of the chamber wall.
Synthesis and Biological Evaluation of 7‐Azaisoindigo Derivatives (2010)

A series of novel 7-azaisoindigo derivatives 3-14 were designed, synthesized, and structurally characterized by IR, 1H-NMR, 13C-NMR, mass spectra, and elemental analyses. Their antiproliferative activities were evaluated in a hormone-independent prostate cancer cell line DU145. Among them, compounds 8, 9, 14 showed the highest activities. Our study also showed that compounds 7, 11, 12 exhibited higher inhibitory activities on CDK2/cyclin A than that of the positive control meisoindigo. Western blot analysis on DU145 cells treated with compounds 7 and 9 demonstrated that 7-azaisoindigo derivatives could decrease the level of CDK2 activity (phosphorylation) and the expression of cyclin D1, and increase the expression of endogenous cyclin-dependent inhibitor p27.
Site-Directed Fragment-Based Screening for the Discovery of Protein–Protein Interaction Stabilizers (2019)

Modulation of protein-protein interactions (PPIs) by small molecules has emerged as a valuable approach in drug discovery. Compared to direct inhibition, PPI stabilization is vastly underexplored but has strong advantages, including the ability to gain selectivity by targeting an interface formed only upon association of proteins. Here, we present the application of a site-directed screening technique based on disulfide trapping (tethering) to select for fragments that enhance the affinity between protein partners. We target the phosphorylation-dependent interaction between the hub protein 14-3-3σ and a peptide derived from Estrogen Receptor α (ERα), an important breast cancer target that is negatively regulated by 14-3-3σ. We identify orthosteric stabilizers that increase 14-3-3/ERα affinity up to 40-fold and propose the mechanism of stabilization based on X-ray crystal structures. These fragments already display partial selectivity toward ERα-like motifs over other representative 14-3-3 clients. This first of its kind study illustrates the potential of the tethering approach to overcome the hurdles in systematic PPI stabilizer discovery.
High-Frequency Transformer-Link Inverter with Regenerative Snubber (2006)

This work proposes a bidirectional high-frequency link inverter using center-tapped high-frequency transformer. The topology also incorporates a regenerative snubber to clamp the high voltage spikes due to the leakage inductance of the transformer. The closed-loop control method used is deadbeat control, which provides fast response and low harmonic distortion, even under nonlinear loads. A 1 kVA prototype inverter is built and the workability of the system is experimentally verified
Motion-induced coherences and density distributions in a Paul-trap (2000)

Summary form only given. Application of an ion trap as a frequency standard requires cooling of the ions or an accurate knowledge of the ion motion to compensate for frequency shifts due to the second-order Doppler effect. In this contribution we report on the observation of atomic coherence effects, which originate from the characteristic motion of Paul. Trapped ions and how these effects can be used for high accuracy measurements of the ion motion. Further we present measurements of the ion cloud distribution, which at higher densities is found to form a hollow ball and we discuss an expanded model for the motion and space distribution of ions in a large trap.
Mathematical model of emmetropization in the chicken (1988)

Recently a number of observations were made on refractive development in chickens and monkeys under various experimental treatments. Degradation of the retinal image by use of occluders produces myopia, although with a high variability in the individual refractions. This kind of image degradation myopia can be induced in the absence of accommodation and with the optic nerve sectioned. In chickens, recovery occurs both in normal birds and in operated birds in which accommodation has been eliminated by lesions in the Edinger Westphal nucleus. In addition, it was shown that, in the chicken eye, growth compensates for an imposed refractive error induced by spectacle lenses. A compensatory change in growth can also be induced in the absence of accommodation. Thus the role of accommodation in the refractive development must be explained. Here we develop a minimal model for regulation of eye growth that provides a possible explanation for all the above observations. A major conclusion is that the presence of two independent feedback loops must be assumed, one dependent on accommodation and one on a local mechanism detecting blur in the retina.
The Forget-me-not Process (2016)

We introduce the Forget-me-not Process, an efficient, non-parametric meta-algorithm for online probabilistic sequence prediction for piecewise stationary, repeating sources. Our method works by taking a Bayesian approach to partition a stream of data into postulated task-specific segments, while simultaneously building a model for each task. We provide regret guarantees with respect to piecewise stationary data sources under the logarithmic loss, and validate the method empirically across a range of sequence prediction and task identification problems.
Reactivity of ideal and defected rutile TiO<sup>2</sup>(110) surface with oxygen (2007)

First principles pseudopotential density functional calculations have been performed to investigate the reactivity of O2 on ideal and defected surface of rutile TiO2 (110). All ionic positions are allowed to relax on slab geometry with periodic boundary conditions. The results reveal that both the molecular and dissociated adsorption of O2 is most favourable on a defective surface in the presence of titanium vacancy and a substantial change in surface relaxation was observed. This remarkable surface ionic displacement and titanium vacancy induced acceptor-like environment favoured in stable adsorption of oxygen for both molecular and dissociated states. The least favourable adsorption or no adsorption of O2 is observed on an ideal surface.
High mobility material channel CMOS technologies based on heterogeneous integration (2011)

CMOS family utilizing III-V/Ge channels on Si substrates can be key devices for high performance and low power advanced LSIs in the future. The critical issues and the key technologies for realizing Ge/III-V-based channel MOSFETs on the Si platform have been addressed. While there are still several critical issues to be solved, recent progresses on the MOS interface control technologies, the Ge/III-V thin body channel formation techniques, the mobility booster technologies including surface orientation engineering and the S/D junction technologies on Ge MOSFETs are making Ge/III-V channel MOSFETs more promising for future applications to high performance and low power advanced LSIs. As a result, we can conclude that ultrathin-body-based Ge/III-V MOSFETs on the Si CMOS platform can be a strong candidate as the device structures under the 15 nm technology node and beyond.
Fast resonance-detection technique for single-frequency operation of injection-seeded Nd:YAG lasers (1986)

A new technique for maintaining single-frequency output from injection-seeded Nd:YAG lasers is described. It involves quickly sweeping the slave-cavity longitudinal-mode spectrum when the flash lamps have created a maximum population inversion. An interference signal is detected by fast electronics, and the Q switch is opened when the slave cavity is resonant with the injected field.
Ophthalmic implants (2004)

The low power consumption of CMOS electronics with onchip co-integrated sensors or actuators makes this technology ideal for the use in implanted systems that need a very low power consumption. Due to the successes in miniaturisation such systems are available for applications inside the eye. In this paper three developments currently worked on in Germany will he described. All systems are powered by the energy of an external RF-field. The first microsystem presented here is a system for measuring the intraocular pressure which is important for the therapy of patients having glaucoma. The second system, the so called retina implant, will help patients suffering from retinitis pigmentosa to get some visual information by stimulating retinal ganglion cells. After heavy accidents like an explosion the cornea often is damaged in such a way that there is up to now no possibility to repair it. For this kind of injury an implantable vision aid is in development by a German research group.
Conditions de l'obtention ou du maintien de la qualité de citoyen de la Nouvelle-Calédonie (2005)

International audience
Allocation of multiport memories for hierarchical data streams (1993)

A multiport memory allocation problem for hierarchical, i.e. multi-dimensional, data streams is described. Memory allocation techniques are used in high level synthesis for foreground and background memory allocation, the design of data format converters, and the design of synchronous inter-processor communication hardware. The techniques presented in this paper differ from other approaches in the sense that data streams are considered to be design entities and are not expanded to individual samples. A formal model for hierarchical data streams is given and a memory allocation algorithm is presented. The algorithm comprises two steps: data routing and assignment of signal delays to memories. A number of sub-problems are formulated as ILP programs. In the presented form, the allocation algorithm only considers interconnect costs, but memory size and other cost factors can be taken into account. The presented work is implemented in the memory allocation tool MEDEA which is part of the PHIDEO synthesis system.
Communication channel equalization based on Levenberg-Marquardt trained artificial neural networks (2013)

Transmitting digital signals through frequency selective communication channel, several problems arise, such as additive noise and ISI (Inter-Symbol Interference). To compensate distortions caused by these factors and to find the original information being transmitted, equalization process is performed at the receiver. Previous authors have shown that nonlinear feed-forward equalizers based on either MLP (Multi Layer Perceptron) or RBF (Radial Basis Function) can outperform linear equalizers. In this paper, we suggest an adaptive neural network equalizer using Levenberg-Marquardt training algorithm, (MLP-LM), which considerably reduces the learning MSE (Mean Square Error) and eliminates efficiently the effects of ISI comparatively to the MLP-BP, RBF and conventional equalizers.
Utilization of Cocoa Pod Husk Waste Composting by Tremella Sp and Pleurotus Sp as A Medium to Growth of Cocoa Seedling (2018)

Cocoa pod husk waste is a problem in the cocoa field, but it potentially as a source of organic matter to improve soil fertility.The paper discuss about the ability of Tremella sp and Pleurotus sp on producing phytohormone and on degrading cocoa pod husks waste. The research start with isolation, screening, and propagation of rot fungi were collected from decayed cocoa plants. The measurement of IAA is according to the method of Glickman and Dessaux (1995), by addition of L-Tryptophan 0.1 g l-1, whereas the Gibberellic Acid content was measured by using the method of Borrow et al., (1955). Composting process of cocoa pod husks waste was revealed during 40 days. This research showed that the IAA and GA3 content in compost fermented with Tremella sp was higher than treatment with Pleurotus sp. Similarly, the result was also observed in the ability of hemicellulose degradation. However, Pleurotus sp was capable to produce compost with higher nutrient levels. Compost fermented by rot fungi gave significant effect to the growth of cocoa seedlings. Nevertheless the difference in varieties of cocoa had no effect on growth of cocoa seedlings. Cocoa pod husk waste composted by Tremella sp and Pleurotus sp gave the significant effect on Leaf Area Index (LAI), Net Assimilation Rate (NAR), Crop Growth Rate (CGR), Root-shoot ratio, and root dry weight of Cocoa seedling.
Recovery of excitability of cutaneous afferents in the median and sural nerves following activity (2000)

In acquired polyneuropathies, symptoms and signs are typically distal and symmetrical, more prominent in the lower limbs than the upper limbs. This study was undertaken to measure the extent of the decrease in excitability produced by single impulses and by impulse trains in cutaneous afferents in the median and sural nerves, and to compare the resulting changes in excitability of these afferents. Threshold tracking was used in 10 healthy subjects to measure the changes in threshold for a compound sensory action potential of 50% maximum produced by conditioning stimuli. Following a single supramaximal conditioning stimulus, the threshold changes occurring during the refractory and supernormal periods were identical for the two nerves, but there was a greater increase in threshold during the late subnormal period for median afferents. Following a train of 10 supramaximal conditioning stimuli, threshold increased by approximately 40% for median afferents and by approximately 20% for sural afferents. These differences are consistent with differences in a slow K(+) conductance. It is suggested that the hypo-excitability produced by brief trains of impulses may be sufficient to disturb conduction in diseased nerve fibers, and that the lesser expression of slow K(+) conductances on cutaneous afferents in the sural nerve could render them more sensitive to depolarizing stresses than median afferents. This could be a factor in the ease with which sural afferents become ectopically active in polyneuropathies.
p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors (2007)

The proapoptotic function of p53 is thought to underlie most anticancer modalities and is also activated in response to oncogenic insults, such as overexpression of the Myc oncoprotein. Here we generated tractable B lymphomas using retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in alleles encoding a fusion between p53 and 4-hydroxytamoxifen (4OHT) receptor (p53ER(TAM)). In these polyclonal tumors, Myc is the only oncogenic lesion, and p53ER(TAM) status can be rapidly toggled between "off" and "on" with 4OHT, provided that the Trp53 promoter has been independently activated. Although 4OHT can trigger widespread apoptosis and overt tumor regression even in the absence of DNA-damaging agents, in tumors with high levels of Mdm2 these responses are blunted. However, cotreatment with proteasome inhibitors fully restores therapeutic effects in vivo. Similarly, human Burkitt lymphomas with wild-type p53 and overexpression of Hdm2 are highly sensitive to proteasome inhibitors, unless p53 levels are reduced using the HPV-E6 ubiquitin ligase. Therefore, proteasome inhibitors could be highly effective as a monotherapy against Myc-induced lymphomas, with no need for adjuvant chemotherapy or radiation therapy. On the other hand, their efficacy is crucially dependent on the wild-type p53 status of the tumor, placing important restrictions on patient selection.
Isolation and preliminary characterization of the 14- to 18-kilodalton Candida albicans antigen as a phospholipomannan containing beta-1,2-linked oligomannosides (1993)

Western blot (immunoblot) analysis of Candida albicans germ tube extracts has demonstrated the probable presence of beta-1,2-linked oligomannosides acting as epitopes distributed over a 14- to 18-kDa antigen unreactive to concanavalin A. These conclusions about the existence of these non-mannan-associated oligomannoside species were reinforced in the present study by the demonstration of reactivity of factor serum 5 (Iatron Laboratories) with the same antigen. A monoclonal antibody which reacted in an enzyme immunoassay with beta-1,2-linked oligomannosides converted into neoglycolipids and in Western blotting with the 14- to 18-kDa antigen from yeast and germ tubes, through metaperiodate-sensitive epitopes, was used for further characterization of the molecule. Reducing agents and strong protease digestion, which have deleterious effects on C. albicans proteins and mannoproteins, affected neither the antigenicity nor the relative molecular weight of the molecule. Western blots performed after migration of protease-treated extracts in polyacrylamide gels without sodium dodecyl sulfate (SDS) showed that the 14- to 18-kDa antigen could be negatively charged, whereas metabolic radiolabeling demonstrated that these charges could originate, at least in part, from the presence of phosphorus within the molecule. Chloroform-methanol-water extraction of protease-resistant material led to purification of the 14- to 18-kDa antigen, as determined by SDS-polyacrylamide gel electrophoresis and Western blotting. Metabolic radiolabeling with mannose confirmed the presence of these sugar residues within the purified 14- to 18-kDa antigen (despite its nonreactivity to concanavalin A), whereas radiolabeling with palmitic acid demonstrated its lipopolysaccharidic nature. Together, these results led to the conclusion that the 14- to 18-kDa antigen is a phospholipomannan.
Airborne Three-Dimensional Cloud Tomography (2015)

We seek to sense the three dimensional (3D) volumetric distribution of scatterers in a heterogenous medium. An important case study for such a medium is the atmosphere. Atmospheric contents and their role in Earth's radiation balance have significant uncertainties with regards to scattering components: aerosols and clouds. Clouds, made of water droplets, also lead to local effects as precipitation and shadows. Our sensing approach is computational tomography using passive multi-angular imagery. For light-matter interaction that accounts for multiple-scattering, we use the 3D radiative transfer equation as a forward model. Volumetric recovery by inverting this model suffers from a computational bottleneck on large scales, which include many unknowns. Steps taken make this tomography tractable, without approximating the scattering order or angle range.