gebhart/patrepeval huggingface dataset:
Directional loudspeaker (1983)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Bruce Howze; Directional loudspeaker. J. Acoust. Soc. Am. 1 April 1983; 73 (4): 1414. https://doi.org/10.1121/1.389191 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Interconnected Carbon Nanosheets Derived from Hemp for Ultrafast Supercapacitors with High Energy (2013)

We created unique interconnected partially graphitic carbon nanosheets (10-30 nm in thickness) with high specific surface area (up to 2287 m(2) g(-1)), significant volume fraction of mesoporosity (up to 58%), and good electrical conductivity (211-226 S m(-1)) from hemp bast fiber. The nanosheets are ideally suited for low (down to 0 °C) through high (100 °C) temperature ionic-liquid-based supercapacitor applications: At 0 °C and a current density of 10 A g(-1), the electrode maintains a remarkable capacitance of 106 F g(-1). At 20, 60, and 100 °C and an extreme current density of 100 A g(-1), there is excellent capacitance retention (72-92%) with the specific capacitances being 113, 144, and 142 F g(-1), respectively. These characteristics favorably place the materials on a Ragone chart providing among the best power-energy characteristics (on an active mass normalized basis) ever reported for an electrochemical capacitor: At a very high power density of 20 kW kg(-1) and 20, 60, and 100 °C, the energy densities are 19, 34, and 40 Wh kg(-1), respectively. Moreover the assembled supercapacitor device yields a maximum energy density of 12 Wh kg(-1), which is higher than that of commercially available supercapacitors. By taking advantage of the complex multilayered structure of a hemp bast fiber precursor, such exquisite carbons were able to be achieved by simple hydrothermal carbonization combined with activation. This novel precursor-synthesis route presents a great potential for facile large-scale production of high-performance carbons for a variety of diverse applications including energy storage.
H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet (2013)

A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures in H7N9 virus-positive live poultry markets have reduced the number of infections; however, the character of the virus, including its pandemic potential, remains largely unknown. We systematically analyzed H7N9 viruses isolated from birds and humans. The viruses were genetically closely related and bound to human airway receptors; some also maintained the ability to bind to avian airway receptors. The viruses isolated from birds were nonpathogenic in chickens, ducks, and mice; however, the viruses isolated from humans caused up to 30% body weight loss in mice. Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet. Our findings indicate nothing to reduce the concern that these viruses can transmit between humans.
Solution Structure of the p53 Regulatory Domain of the p19<sup>Arf</sup> Tumor Suppressor Protein (2001)

Arf is a tumor suppressor that regulates p53 function and is a frequent target for loss in human cancers. Through two novel mechanisms, Arf inhibits the oncoprotein Hdm2, a negative regulator of p53. (1) Arf inhibits the E3 ubiquitin ligase activity of Hdm2 that leads to p53 degradation, and (2) Arf sequesters Hdm2 within nucleoli. These activities of Arf promote p53-mediated cell cycle arrest and apoptosis. Fundamental to these processes are interactions between Arf and Hdm2. Here we show that a peptide containing the 37 N-terminal amino acids of mouse Arf (mArfN37) localizes to nucleoli, sequesters Hdm2 within nucleoli, and causes cell cycle arrest. Circular dichroism and NMR spectroscopy show that mArfN37 is largely unstructured under aqueous conditions; however, the peptide adopts two alpha-helices (helix 1, residues 4-14; and helix 2, residues 20-29) in 2,2,2-trifluoroethanol (TFE). Each helix contains an amino acid motif that is repeated twice in mArfN37, once in each helix. The two helices, however, do not interact but are connected by an apparently flexible linker. The repeated motif contains Arg residues spaced by a hydrophobic segment that may be involved in Hdm2 recognition and binding. The RRPR nucleolar localization signal, contained within residues 31-34, appears to be disordered under all conditions. The identification of two Arf structural modules suggests that short peptides containing the repeated motif may function as Arf mimics and may allow the design of small molecule Arf mimics in the future.
Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase (2019)

G-quadruplex (GQ) stabilizing small molecule (SM) ligands have been used to stabilize human telomeric GQ (hGQ) to inhibit telomerase activity, or non-telomeric GQs to manipulate gene expression at transcription or translation level. GQs are known to inhibit DNA replication unless destabilized by helicases, such as Bloom helicase (BLM). Even though the impact of SM ligands on thermal stability of GQs is commonly used to characterize their efficacy, how these ligands influence helicase-mediated GQ unfolding is not well understood. Three prominent SM ligands (an oxazole telomestatin derivative, pyridostatin, and PhenDC3), which thermally stabilize hGQ at different levels, were utilized in this study. How these ligands influence BLM-mediated hGQ unfolding was investigated using two independent single-molecule approaches. While the frequency of dynamic hGQ unfolding events was used as the metric in the first approach, the second approach was based on quantifying the cumulative unfolding activity as a function of time. All three SM ligands inhibited BLM activity at similar levels, 2-3 fold, in both approaches. Our observations suggest that the impact of SM ligands on GQ thermal stability is not an ideal predictor for their inhibition of helicase-mediated unfolding, which is physiologically more relevant.
A 600 MHz CMOS PLL microprocessor clock generator with a 1.2 GHz VCO (2002)

A clock multiplier for the 600 MHz 72 W (estimated) CMOS Alpha microprocessor is presented. The supply voltage of the analog part of the PLL (VDDA) is provided by an on-chip voltage regulator with a decoupling capacitance. The 3.3 V supply is used to generate the quieter internal supply voltage needed for the sensitive analog part of the PLL and allows the regulator to operate properly even if the 3.3 V supply is noisy. A bandgap voltage reference is used to generate an internal reference for the supply voltage of 2.2 V. The regulator PSRR is always larger than 20 dB in the frequency range of the power supply noise, reducing the noise amplitude on the analog-supply voltage. The minimum measured supply voltage for the regulator is 2.5 V with a regulated output of 2.2 V (without noise generator).
Item analysis in language assessment (2019)

This chapter introduces the reader to the important role that item analysis plays when exploring language test data. This analysis is usually the first statistical procedure to take place once the test data have been entered into a program such as IBM SPSS or Winsteps. It provides three types of information: first of all, it indicates the difficulty level of each item (also referred to as the facility value); in other words, it tells the researcher how many test takers have answered the item correctly. Second, the analysis provides insights into how well the items discriminate between the test takers and thus whether the stronger ones are answering the items correctly and the weaker answering them incorrectly. Third, it demonstrates the degree to which each individual item is contributing to the task’s internal consistency reliability, that is, whether the items are measuring the same construct. A sample study, based on a task consisting of 11 multiple-choice items, which was given to 102 test takers, is used to illustrate these three procedures of item analysis.
Soybean resistance genes specific for different Pseudomonas syringae avirulence genes are allelic, or closely linked, at the RPG1 locus. (1995)

RPG1 and RPM1 are disease resistance genes in soybean and Arabidopsis, respectively, that confer resistance to Pseudomonas syringae strains expressing the avirulence gene avrB. RPM1 has recently been demonstrated to have a second specificity, also conferring resistance to P. syringae strains expressing avrRpm1. Here we show that alleles, or closely linked genes, exist at the RPG1 locus in soybean that are specific for either avrB or avrRpm1 and thus can distinguish between these two avirulence genes.
Expression of galectin-3 in gastric carcinoma and its significance (2004)

Objective: To study the expression of Galectin-3 in gastric cancerous tissues and the relationship between Galectin-3 expression and biological behave of gastric carcinoma. Methods: S-P immunohistochemistry method was used to examine Galectin-3 expression in 64 primary gastric cancerous tissues and 10 normal gastric mucosa as control. The expression of Galectin-3 was examined by HPIAS- 2000 image analysis software. Results: Positive Gaiectin-3 expression was observed in 85.9% of the gastric cancer cases. In gastric cancerous tissues, about 46% of cases showed strong nuclear immunoreactivity. The degree of enhancement of immunoreactivity was different in various histopathological subtypes in cancerous tissues. The readings of average absorbency of Galectin-3 in well, moderate and poorly differentiated adenocarcinoma tissues were 0.1713±0.02147, 0.1873±0.0313 and 0.2538±0.1216 respectively. A stronger expression of Galectin-3 in cancerous tissues was observed. When Galectin-3 expression in gastric cancerous tissues was compared with that in normal gastric tissues, there was a significant difference (P<0.001). Conclusion: A significantly stronger expression of Galectin-3 in gastric cancerous tissues was observed. Galectin-3 might be a useful tumor marker for gastric carcinomas with respects to tumor metastasis, proliferation, cancer progression, and tumor cell adhesion.
Performance monitoring of a wireless campus area network (2002)

In the relatively new field of wireless local area networks there exist three methods for performance evaluation: (1) mathematical analysis; (2) computer simulation; and (3) performance monitoring of a testbed. The data obtained from mathematical analysis and computer simulation are purely speculative, there is simply no way these methods can address all of the complexities associated with network protocols and indoor radio propagation. For this reason, the most useful performance data on wireless LAN hardware is that which is obtained directly from a fully functional working testbed. The National Science Foundation has provided funding for such a testbed that has been installed at the Center for Wireless Information Network Studies (CWINS) at Worcester Polytechnic Institute, Worcester, MA. The authors present the data obtained from this testbed. Their findings show the feasibility and practicality of installing an indoor wireless local area network.
Enteroaggregative Escherichia coli infection (2008)

There has been significant progress in understanding the pathogenesis and clinical profile of EAEC infection.
S-band amplifier with variable gain tilt control (2002)

We present a method of variable gain tilt control for a thulium doped fiber amplifier (TDFA) using a mid-stage attenuator, together with measurements of the amplifier performance. The addition of tilt control allows S-band amplifiers to be used with a wide array of fibers and channel configurations since the effect of both Raman interactions and the O-H absorption peak can be compensated at installation. This is particularly important when adding amplifiers to an existing system, which may not be fully characterized in the S and S+ bands. The simplicity of using a variable attenuator to produce gain tilt, combined with the very short active-fiber lengths, allows manufacture at similar costs to erbium amplifiers.
Beam Forming for Large-scale Phased Array Antennas (2002)

For high-data-rate satellite communication systems, the satellite must need high performance onboard equipment. To improve the onboard antenna performance in higher frequency band, the circuits scale of active phased array antennas take a tendency to become large. This paper presents a novel beam forming technique for onboard large-scale active phased array antennas. The proposed technique uses fewer phase control circuits than the conventional technique. The proposed technique is validated by antenna pattern simulations. The design of an onboard large-scale phased-array-fed reflector antenna based on the proposed technique is described for high-data-rate satellite communication systems.
Combination therapy in idiopathic pulmonary fibrosis: the way ahead will be hard (2015)

In retrospect, 2014 will be seen as the year in which idiopathic pulmonary fibrosis (IPF) therapies came of age. Treatment effects reported previously were inconclusive with regard to both pirfenidone (two positive studies [1, 2] and a negative study [2]) and nintedanib (a single phase II study in which trends were marginal due to under-powering [3]). The ASCEND pirfenidone trial [4] and the two INPULSIS nintedanib trials [5] ended uncertainty. The two agents appear remarkably similar in both tolerability and efficacy, with a 50% reduction in forced vital capacity (FVC) decline. Whither now? No biomarker data exist to indicate that either agent might be more efficacious in individual patients. Initially, the routine use of these therapies is likely to be sequential, with one agent replaced by the other when side-effects are problematic or treatment failure is evident, however this is defined. In the longer term, combinations of pirfenidone and nintedanib appear attractive in principle, based both on the possibility of synergy in a disease in which there is a multiplicity of coactivated pathways, and also on precedence in other lung diseases including asthma, chronic obstructive pulmonary disease, lung cancer and pulmonary artery hypertension [6]. However, the road to combination regimens in IPF is likely to have many twists and turns. Two particular problems need to be addressed, even supposing that additive or synergistic benefits exist (something that has yet to be established). Tolerability issues are important, as both agents give rise to significant gastrointestinal side-effects. It should also be understood from the outset that demonstrating efficacy will not be straightforward. Intense multinational activity was needed to show treatment benefits against placebo arms characterised by FVC declines approximating 220 mL·year−1. The treatment advances of 2014 sound the death knell of placebo-controlled evaluation in IPF: it seems inevitable that combination regimens will be compared with monotherapy. The rate of FVC decline of approximately 110 mL·year−1 in patients receiving either pirfenidone or nintedanib will pose major challenges with regard to powering future trials [6]. The current issue of the European Respiratory Journal ( ERJ ) features two studies that are highly relevant to tolerability and study design issues. Combination therapy is the future for IPF treatment but many questions remain regarding tolerability and study design <http://ow.ly/Kuykl>
Thermal quenching of <i>F</i>-center luminescence in Al2O3:C (1998)

Using time-resolved photoluminescence spectroscopy we have measured the lifetime of the F-center luminescence from α-Al2O3:C. The measurements reveal a lifetime of 35–36 ms at room temperature, decreasing to &lt;2 ms over the temperature range from 370 to 500 K. The decrease in the lifetime is shown to follow a classical Mott-Seitz dependence for thermal quenching of luminescence, with an activation energy W of ∼1.08±0.03 eV and a corresponding frequency factor ν of ∼1014 s−1. Similar values for the energy and frequency factor were also obtained from an analysis of thermoluminescence (TL) glow curves measured at different heating rates, when the TL is measured over a wavelength range corresponding to the F-center luminescence emission (centered at 420 nm). Furthermore, the parameters obtained were independent of the glow curve shape, the degree of trap filling, or the specific conditions under which the crystals were grown. This is interpreted as a demonstration that the well-known heating rate dependence of the TL from this material is a result of thermal quenching of the F-center emission. Whereas the thermal quenching parameters obtained from measurement of the luminescence lifetime and from the heating rate analysis of the TL glow curves are independent of the sample type, the degree of trap filling, and the heating or cooling rate, measurements of the photoluminescence intensity, induced by absorption of F-band light, were found to be dependent upon all of the above conditions. This difference in behavior is attributed to a phosphorescence signal from traps associated with the ∼265, ∼310, and ∼450 K TL peaks.
The Twist Box Domain Is Required for Twist1-induced Prostate Cancer Metastasis (2013)

Targeting the Twist box domain of Twist1 may effectively limit prostate cancer metastatic potential.
Empowering Requirements Elicitation Interviews with Vocal and Biofeedback Analysis (2016)

Interviews with stakeholders are the most commonly used elicitation technique, as they are considered one of the most effective ways to transfer knowledge between requirements analysts and customers. During these interviews, ambiguity is a major obstacle for knowledge transfer, as it can lead to incorrectly understood needs and domain aspects and may ultimately result in poorly defined requirements. To address this issue, previous work focused on how ambiguity is perceived on the analyst side, i.e., when the analyst perceives an expression of the customer as ambiguous. However, this work did not consider how ambiguity can affect customers, i.e., when questions from the analyst are perceived as ambiguous. Since customers are not in general trained to cope with ambiguity, it is important to provide analysts with techniques that can help them to identify these situations. To support the analysts in this task, we propose to explore the relation between a perceived ambiguity on the customer side, and changes in the voice and bio parameters of that customer. To realize our idea, we plan to (1) study how changes in the voice and bio parameters can be correlated to the levels of stress, confusion, and uncertainty of an interviewee and, ultimately, to ambiguity and (2) investigate the application of modern voice analyzers and wristbands in the context of customer-analyst interviews. To show the feasibility of the idea, in this paper we present the result of our first step in this direction:an overview of different voice analyzers and wristbands that can collect bio parameters and their application in similar contexts. Moreover, we propose a plan to carry our research out.
Analyzing travel time distribution based on different travel time reliability patterns using probe vehicle data (2019)

Travel time distribution (TTD) has been widely used to represent the traffic conditions on freeways and help to analyze travel time reliability (TTR). The goal of this study is to develop a systematic approach to analyzing TTD on different types of roadway segments along a corridor. By examining the historical TTR pattern using planning time index (PTI), four typical segments are identified and selected first. The distributions of travel time are then analyzed under different time of day, day of week, segment location and weather. The goodness-of-fit tests of different distributions are then conducted, and the results indicate that Burr distribution can provide highest acceptance rate with the consideration of different times of day (TOD) and days of week (DOW). The results also indicate that Burr distribution can provide highest acceptance rate with the consideration of different weather conditions. This study can provide the insightful information about TTD characteristics under different scenarios, and the results can also help transportation planners make informed decisions.
Computed Tomography and Outcome in Moderate and Severe Traumatic Brain Injury: Hematoma Volume and Midline Shift Revisited (2011)

Intracranial lesion volume and midline shift are powerful outcome predictors in moderate and severe traumatic brain injury (TBI), and therefore they are used in TBI and computed tomography (CT) classification schemes, like the Traumatic Coma Data Bank (TCDB) classification. In this study we aimed to explore the prognostic value of lesion volume and midline shift in moderate and severe TBI as measured from acute cranial CT scans. Also, we wanted to determine interrater reliability for the evaluation of these CT abnormalities. We included all consecutive moderate and severe TBI patients admitted to our hospital who were aged ≥16 years, over an 8-year period, as part of the prospective Radboud University Brain Injury Cohort Study. Six months post-trauma we assessed outcomes using the Glasgow Outcome Scale-Extended (GOS-E). We analyzed 605 patients and found an association of both lesion volume and midline shift with outcome; increases were associated with a higher frequency of patients with an unfavorable outcome or death. A cut-off value, such as that used in the TCDB CT classification (lesion volume 25 mL and midline shift 5 mm), was not found. The average interrater difference in volume measurement was 6.8 mL, and it was 0.2 mm for the determination of degree of shift. Using lesion volume and midline shift as continuous variables in prognostic models might be preferable over the use of threshold values, although an association of these variables with outcome in relation to other CT abnormalities was not tested. The data provided here will be useful for stratification of patients enrolled in clinical trials of neuroprotective therapies.