gebhart/patrepeval huggingface dataset:
Effect of reduced exposure times on the microhardness of 10 resin composites cured by high-power LED and QTH curing lights. (2006)

The ability to reduce exposure times with high-power LED or QTH lights may improve clinical time management.
A programmable baseband processor design for software defined radios (2004)

Future wireless systems need extremely fast and flexible architectures to support varying standards, algorithms and protocols with data rates in the range of 10-100 Mbps. Software Defined Radios (SDRs) based on DSP-FPGAs are a widely proposed solution for these systems. However, these SDR solutions have not been able to meet real-time requirements. We propose a programmable architecture solution for SDRs using a stream-based architecture based on the Imagine media processor. The configurable Imagine simulator allows us to investigate issues such as memory bottlenecks, number and type of functional units needed, and the utilization of those functional units. To evaluate stream-based architectures for baseband processing, we parallelize and implement sophisticated baseband algorithms including multiuser estimation, multiuser detection and Viterbi decoding on this simulator. We present the bottlenecks in such a stream-based architecture for efficient communications processing. Comparisons with current generation DSP-based solutions show orders-of-magnitude performance improvements, both due to the stream-based nature of computations as well as the increase in the number of functional units having a high utilization factor. The result is a baseband processor designed with broad system functionality and flexibility that approaches real-time performance for future wireless systems.
Systematic comparison of perfusion‐CT and CT‐angiography in acute stroke patients (2007)

The most accurate assessment of the site of occlusion, infarct core, salvageable brain tissue, and collateral circulation in patients suspected of acute stroke is afforded by a combination of PCT and CTA.
Fenretinide Perturbs Focal Adhesion Kinase in Premalignant and Malignant Human Oral Keratinocytes. Fenretinide's Chemopreventive Mechanisms Include ECM Interactions (2015)

The membrane-associated protein, focal adhesion kinase (FAK), modulates cell-extracellular matrix interactions and also conveys prosurvival and proliferative signals. Notably, increased intraepithelial FAK levels accompany transformation of premalignant oral intraepithelial neoplasia (OIN) to oral squamous cell carcinoma (OSCC). OIN chemoprevention is a patient-centric, optimal strategy to prevent OSCC's comorbidities and mortality. The cancer chemopreventive and synthetic vitamin A derivative, fenretinide, has demonstrated protein-binding capacities, for example, mTOR- and retinol-binding protein interactions. These studies used a continuum of human oral keratinocytes (normal-HPV E6/E7-transduced-OSCC) to assess potential fenretinide-FAK drug protein interactions and functional consequences on cellular growth regulation and motility. Molecular modeling studies demonstrated that fenretinide has approximately 200-fold greater binding affinity relative to the natural ligand (ATP) at FAK's kinase domain. Fenretinide also shows intermediate binding at FAK's FERM domain and interacts at the ATP-binding site of the closest FAK analogue, PYK2. Fenretinide significantly suppressed proliferation via induction of apoptosis and G2-M cell-cycle blockade. Fenretinide-treated cells also demonstrated F-actin disruption, significant inhibition of both directed migration and invasion of a synthetic basement membrane, and decreased phosphorylation of growth-promoting kinases. A commercially available FAK inhibitor did not suppress cell invasion. Notably, although FAK's FERM domain directs cell invasion, FAK inhibitors target the kinase domain. In addition, FAK-specific siRNA-treated cells showed an intermediate cell migration capacity; data which suggest cocontribution of the established migrating-enhancing PYK2. Our data imply that fenretinide is uniquely capable of disrupting FAK's and PYK2's prosurvival and mobility-enhancing effects and further extend fenretinide's chemopreventive contributions beyond induction of apoptosis and differentiation.
Intermediate dose single agent cyclophosphamide chemotherapy of advanced breast cancer. (1983)

Twenty-one evaluable patients with metastatic breast cancer received three pulses of intravenous cyclophosphamide, escalating from 1.5 g/m2 to 2.5 g/m2 in the second and third courses. There were eight partial remissions (34.7%), but most were of short duration. All responding patients had soft tissue or nodal disease, but additional sites of response were bone (three cases), liver and lung (one case each). Marked leucopaenia (median WBC 0.7 X 10(9)/L) occurred 10-12 days after the higher doses (2.5 g/m2) and was associated with nine episodes of severe infection in five patients. Marked vomiting and anorexia led to significant weight loss (mean 4.5 kg) in half the patients, and alopecia was universal. In metastatic breast cancer cyclophosphamide seems to have a shallow dose response curve and high intermittent dosage seems to have no advantage over chronic daily administration.
Laparoscopic Prostatectomy for Severely Symptomatic, Treatment-Refractory Chronic Prostatitis: Preliminary Observations from an Ongoing Phase II Clinical Trial (2011)

doi:10.3834/uij.1944-5784.2011.04.12 http://www.urotodayinternationaljournal.com ISSN 1944-5792 (print), ISSN 1944-5784 (online) Arnon Krongrad,1 Shenghan Lai2 1The Krongrad Institute, Aventura, FL, USA; 2Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA Submitted November 3, 2010 Accepted for Publication February 23, 2011 www.urotodayinternationaljournal.com Volume 4 April 2011
Effect of mannanoligosaccharides, inulin and yeast nucleotides added to calf milk replacers on rumen microflora, level of serum immunoglobulin and health condition of calves (2011)

The aim of study was to determine effect of applied in calf milk replacer feed additives – mannanooligosaccharides, inulin and yeast nucleotides on rumen microflora, level of serum immunoglobulin and calf health condition. The results of research related to effect of mannanooligosaccharides, inulin and yeast nucleotides added to calf milk replacers on calf rearing and health condition point to higher final body weight as well as higher daily body weight gains, better concentrate intake and feed conversion ratio all rearing long. Feed additives, especially yeast nucleotides had beneficial influence on faeces scores – better consistency (less watery and well formed). It can testify to better calf health condition. Additives applied in calf milk replacers did not clearly affect on morphological and biochemical blood and serum parameters. Merely blood glucose increased while levels of cholesterol and plasma urea N were reduced. The higher level gamma-globulin as well as better passive immunity transfer were stated in calves receiving mannanooligosaccharides and yeast nucleotides in amount 4 g/day/head in milk replacer. Applied in calf milk repalcers mannanooligosaccharides, inulin and yeast nucleotides, especially inulin in amount 6 g/day/head increased calf rumen pH and decreased level of rumen ammonium nitrogen. Concentration of total volatile fatty acids in rumen, especially acetate and propionate were higher in calves receiving in milk replacer prebiotic feed additives, especially mannanooligosaccharides and yeast nucleotides what was confirmed by higher body weight gains. Moreover the total bacteria count increased while the concentration of protozoa in the rumen fluid decreased, particularly in calves receiving inulin.
Plant Foods and Herbal Sources of Resveratrol (2002)

Stilbenes, in particular trans-resveratrol and its glucoside, are widely reported to be beneficial to health, having been shown to possess antioxidative, anticarcinogenic, and antitumor properties. Major dietary sources include grapes, wine, peanuts, and soy; however, they can also be introduced into the diet through Itadori tea, which has long been used in Japan and China as a traditional herbal remedy for heart disease and strokes. Analysis of grapes, peanuts, and Itadori tea shows that they contain mainly trans-resveratrol glucoside. In contrast, red wines are primarily a source of the aglycones cis- and trans-resveratrol. While peanuts and grapes contain low levels of the stilbenes, Itadori tea and red wine both supply relatively high concentrations of resveratrol. For people who do not consume alcohol, Itadori tea may be a suitable substitute for red wine. However, further study on the potential biological effects of other endogenous compounds in Itadori tea is required and there is also a need for more information on the absorption and in vivo biomedical actions of free and conjugated resveratrol.
Vehicle Stability Enhancement of Four-Wheel-Drive Hybrid Electric Vehicle Using Rear Motor Control (2008)

A vehicle stability enhancement control algorithm for a four-wheel-drive hybrid electric vehicle (HEV) is proposed using rear motor driving, regenerative braking control, and electrohydraulic brake (EHB) control. A fuzzy-rule-based control algorithm is proposed, which generates the direct yaw moment to compensate for the errors of the sideslip angle and yaw rate. Performance of the vehicle stability control algorithm is evaluated using ADAMS and MATLAB Simulink cosimulations. HEV chassis elements such as the tires, suspension system, and steering system are modeled to describe the vehicle's dynamic behavior in more detail using ADAMS, whereas HEV power train elements such as the engine, motor, battery, and transmission are modeled using MATLAB Simulink with the control algorithm. It is found from the simulation results that the driving and regenerative braking at the rear motor is able to provide improved stability. In addition, better performance can be achieved by applying the driving and regenerative braking control, as well as EHB control.
Electric-Field-Enhanced Adsorption of Chiral Molecules on Ferromagnetic Substrates (2019)

The effect of an electric field on the adsorption of oligopeptides and DNA on a ferromagnetic substrate magnetized perpendicular to the surface was investigated. The direction of the magnetic moment of the substrate defines different adsorption rates for different enantiomers, and the direction of the electric field, perpendicular to the surface, defines different adsorption rates depending on the direction of the dipole moment of the adsorbed molecules.
Aspirin-Triggered Lipoxins Override the Apoptosis-Delaying Action of Serum Amyloid A in Human Neutrophils: A Novel Mechanism for Resolution of Inflammation (2007)

Elevated plasma levels of the acute-phase reactant serum amyloid A (SAA) have been used as a marker and predictor of inflammatory diseases. SAA regulates leukocyte activation; however, it is not known whether it also modulates neutrophil apoptosis, which is critical to the optimal expression and resolution of inflammation. Culture of human neutrophils with SAA (0.1-20 microg/ml) markedly prolonged neutrophil longevity by delaying constitutive apoptosis. SAA evoked concurrent activation of the ERK and PI3K/Akt signaling pathways, leading to phosphorylation of BAD at Ser(112) and Ser(136), respectively, and to prevention of collapse of mitochondrial transmembrane potential, cytochrome c release, and caspase-3 activation. These actions were abrogated by pharmacological inhibition of the formyl peptide receptor, ERK or PI3K. Furthermore, aspirin-triggered 15-epi-lipoxin A(4) (15-epi-LXA(4)) and its stable analog 15-epi-16-p-fluorophenoxy-LXA(4), which binds to the same receptor as SAA, effectively overrode the antiapoptosis signal from SAA even when neutrophils were treated with 15-epi-LXA(4) at either 1 or 4 h postculture with SAA. 15-Epi-LXA(4) itself did not affect neutrophil survival and apoptosis. Our results indicate that SAA at clinically relevant concentrations promotes neutrophil survival by suppressing the apoptotic machinery, an effect that can be opposed by 15-epi-LXA(4). The opposing actions of SAA and aspirin-triggered 15-epi-LXA(4) may contribute to the local regulation of exacerbation and resolution of inflammation, respectively.
Field desorption mass spectrometry. II. Potassium cationization field desorption mass spectrometry of some penta- and hexapeptides derived from substance P. (1981)

In this article we present preliminary results of the application of potassium cationized field desorption mass spectrometry as an additional technique for the elucidation of structure and evaluation of purity of oligopeptides such as C-terminal penta- and hexapeptide analogs of substance P. In the resultant mass spectra both a protonated and a cationized molecular ion, MH+ and MK+ respectively, were observed. The m/z values of the two peaks were in agreement with the calculated molecular weights. The ratio between the relative abundancies of these ions (MH+/MK+) was found to be characteristic of the particular peptide and thus useful in the assessment of their purity. Among the 13 peptides studied, only two gave pyrolytic fragmentation leading to a more complex spectra.
Whole-brain calcium imaging with cellular resolution in freely behaving <i>Caenorhabditis elegans</i> (2015)

The ability to acquire large-scale recordings of neuronal activity in awake and unrestrained animals is needed to provide new insights into how populations of neurons generate animal behavior. We present an instrument capable of recording intracellular calcium transients from the majority of neurons in the head of a freely behaving Caenorhabditis elegans with cellular resolution while simultaneously recording the animal's position, posture, and locomotion. This instrument provides whole-brain imaging with cellular resolution in an unrestrained and behaving animal. We use spinning-disk confocal microscopy to capture 3D volumetric fluorescent images of neurons expressing the calcium indicator GCaMP6s at 6 head-volumes/s. A suite of three cameras monitor neuronal fluorescence and the animal's position and orientation. Custom software tracks the 3D position of the animal's head in real time and two feedback loops adjust a motorized stage and objective to keep the animal's head within the field of view as the animal roams freely. We observe calcium transients from up to 77 neurons for over 4 min and correlate this activity with the animal's behavior. We characterize noise in the system due to animal motion and show that, across worms, multiple neurons show significant correlations with modes of behavior corresponding to forward, backward, and turning locomotion.
Solubility of stearic acid in various organic solvents and its prediction using non-ideal solution models (2007)

The solubility of stearic acid in ethanol, methanol, ethyl acetate, and acetone has been measured gravimetrically at various temperatures ranging from 301 to 313 K at atmospheric condition. The solubility of stearic acid in ethyl acetate was found to be the highest, followed by ethanol, acetone and methanol. All experimental data were correlated using non-ideal solution models, namely, the modified Apelblat and the Buchowski equations. The calculated results agreed well with the experimental data.
A refined two-step oligoribonucleotide interference-PCR method for precise discrimination of nucleotide differences (2018)

We previously developed oligoribonucleotide (ORN) interference-PCR (ORNi-PCR), in which an ORN hybridises with a complementary DNA sequence and inhibits PCR amplification across the sequence in a sequence-specific manner. Suppression of target amplification by ORNi-PCR can be used to detect nucleotide differences such as mutations in a target sequence. In the present study, we refined the ORNi-PCR method and established a detailed technical protocol to precisely discriminate single-nucleotide differences. We first revealed that a two-step (denaturing and annealing plus elongation) rather than a standard three-step (denaturing, annealing and elongation) method is more suitable for stably hybridising an ORN to its target DNA sequence for sequence-specific suppression of target amplification. We then optimised the ORNi-PCR method using two-step cycles and established a step-by-step technical protocol. The optimised Two-Step ORNi-PCR method could discriminate single-nucleotide differences in genomic DNA or cDNA introduced by genome editing or mutations in cancer cells. In addition, we showed that Two-Step ORNi-PCR can detect the cancer cells possessing a single nucleotide mutation in a target locus mixed with a large number of cells harboring wild-type sequences in the locus so that the number of the cancer cells is only 0.2% of the total cell number. Two-Step ORNi-PCR is useful for simple, precise, cost-effective and positive detection of nucleotide differences in a wide range of molecular biology and medical applications.
Role of the charged tail in localization of a surface protein antigen of Streptococcus mutans (1997)

To make clear the role of the C terminus of a surface protein antigen (PAc) of Streptococcus mutans, stepwise truncations beginning at the C terminus of PAc were performed by utilizing site-directed mutagenesis. A remarkable increase in the amount of cell-free PAc was observed upon deletion of four or more amino acid residues at the C terminus. On the other hand, the amount of cell surface PAc gradually decreased when increasing numbers (four or more) of amino acid residues were deleted at the C terminus, and deletion of six amino acids involving both the total charged tail and Leu, an amino acid residue immediately upstream of the charged tail, resulted in a drastic reduction in the amount of cell surface PAc. These results indicate that the cytoplasmic charged tail and Leu residue are required for cell surface localization of PAc in S. mutans.
Monitoring Working Memory Load during Computer-Based Tasks with EEG Pattern Recognition Methods (1998)

We assessed working memory load during computer use with neural network pattern recognition applied to EEG spectral features. Eight participants performed high-, moderate-, and low-load working memory tasks. Frontal theta EEG activity increased and alpha activity decreased with increasing load. These changes probably reflect task difficulty-related increases in mental effort and the proportion of cortical resources allocated to task performance. In network analyses, test data segments from high and low load levels were discriminated with better than 95% accuracy. More than 80% of test data segments associated with a moderate load could be discriminated from high- or low-load data segments. Statistically significant classification was also achieved when applying networks trained with data from one day to data from another day, when applying networks trained with data from one task to data from another task, and when applying networks trained with data from a group of participants to data from new participants. These results support the feasibility of using EEG-based methods for monitoring cognitive load during human-computer interaction.
Thermologic methods in clinical pharmacology-skin temperature measurement in drug trials. (1984)

With the increasing availability of thermographic equipment the definition of "thermography" and "thermologic methods" is important, since differing techniques and standards may be applied. Recommendations are given for optimum use of skin-surface temperature measurements in the assessment of clinical drug trials. Sites for thermographic measurement, different methods for quantitation, and sources of further information are included. A brief checklist of minimal technical requirements and an example of information for patients are also included.
Experimental Demagnetizing Factors for Disk Samples Magnetized Along a Diameter (2007)

Demagnetizing factors for disk samples of a commercial 80Ni permalloy have been measured using a vibrating sample magnetometer with fields provided by a Helmholtz coil pair. The range of values of m (diameter/thickness) is from 12.5 to 385. The experimental values of N are significantly higher than those calculated for an ellipsoid, but lower than those calculated assuming uniform magnetization
An overview of the IRIDIUM (R) low Earth orbit (LEO) satellite system (2002)

This paper provides a tutorial overview of the IRIDIUM(R) low earth orbit (LEO) satellite system. Section I contains an introduction to the IRIDIUM(R) network as well as the system specifications. Section II discusses the satellite constellation design, orbital parameters, and horizontal pointing angles between satellites. Section III introduces the idea of time dependent connectivity in a mobile network, and analyzes the cycle of network connectivity for IRIDIUM(R). Section IV discusses the IRIDIUM(R) Time Division Multiple Access (TDMA) and Frequency Division Multiple Access (FDMA) schemes and uses these to calculate the overall system capacity. Section V examines the call processing procedure to include user location and call set up. Finally, Section VI analyzes the network performance in terms of end-to-end delay and hop count.
Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts. (1992)

GLUT1, the erythrocyte glucose transporter, and GLUT4, the adipose/muscle transporter, were each expressed in NIH-3T3 cells by retrovirus-mediated gene transfer. In fibroblasts overexpressing GLUT1, basal as well as insulin-stimulated deoxyglucose uptake was increased. Expression of GLUT4 was without affect on either basal or hormone stimulated hexose uptake. Localization of each of the transporters by indirect immunofluorescence revealed that, whereas GLUT1 was found primarily on the cell surface, GLUT4 was directed to vesicles in a perinuclear distribution and throughout the cytoplasm. The GLUT4-containing compartment represented neither Golgi complex nor lysosomes, as evidenced by the failure of lgp110 or Golgi mannosidase to co-localize. However, there was substantial overlap between the distribution of GLUT4 and the transferrin receptor, and some colocalization of the transporter isoform with the manose-6-phosphate receptor. In addition, when FITC-wheat germ agglutinin bound to the cell surface was allowed to internalize at 37 degrees C, it concentrated in vesicular structures coincident with GLUT4 immunoreactivity. These data establish that GLUT1 and GLUT4 contain within their amino acid sequences information which dictates targeting to distinct cellular compartments. Moreover, GLUT4 can be recognized by those cellular factors which direct membrane proteins to the endosomal pathway.