gebhart/patrepeval huggingface dataset:
An adaptive scheme to synthesize broadband signals for a parametric array (1980)

An adaptive signal synthesis technique is presented that computes the waveform needed as input to a parametric array source so that the farfield received signal has a prescribed waveform for a particular source receiver geometry. The technique uses the Fourier transform of the digitized received signal waveform as a basis for modifying the source signal recursively until the received waveform is close to a desired shape. The method avoids completely the numerical integrations normally associated with parametric source signal design and converges to a satisfactory result within a few iterations. Thus, it is fast enough to be used on line. The theory underlying the method is outlined and several examples of signals designed using the instrumentation of the Yale Hydroacoustic Communications Facility are shown. [Work supported by NSF.]
An FPGA Solution for Radiation Dose Calculation (2006)

Radiation dose calculation is an important step in the treatment of cancer patients requiring radiation therapy. It ensures that the physician prescribed dose agrees with the dose delivered to the patient. Current methods use software implementing either three-dimensional (3D) convolution/superposition algorithms or Monte Carlo analysis. These software methods create a bottleneck in radiation therapy. The required computation time limits both the accuracy of the calculation and the number of patients whom can be treated. This paper presents a novel FPGA implementation for radiation dose calculation. The implementation is based on the 3D convolution/superposition collapsed cone algorithm (Ahnesjo, 1989). To achieve higher accuracy and performance, the original algorithm has been modified and advanced design techniques were applied. Experimental data demonstrate that the FPGA implementation shows significant improvements over software implementation
Laboratory-Scale Study of Electrolytic Reduction of Uranium Oxides (1988)

Report of an exploratory study undertaken to investigate potential improvements in the electrolytic reduction of uranium oxide to the metal.
The Feasibility of High-Flow Nacelle Bypass for Low Sonic Boom Propulsion System Design (2011)

A new supersonic design methodology has been developed by Gulfstream Aerospace Corporation for expanding the design space of a nacelle to reduce its contribution to an aircraft’s sonic boom signature. This method uses high-flow nacelle bypass to permit more latitude in the shaping of the nacelle’s surface, in particular the reduction of its axial slope at the intake entrance and nozzle exit. In doing so, the cowl shock strength and the aft nacelle’s expansion-reshock amplitude are both substantially reduced. The most significant unknown with this concept had been the practicality of internally bypassing a very large fraction of total captured airflow around the engine while avoiding unacceptable pressure loss. A unique curved channel arrangement was designed to divert the bypass flow around the massive blockage profile created by the engine gearbox. Internal choking and supersonic expansion combine to maintain a favorable pressure gradient through the length of the bypass. A configuration bypassing 40 percent of captured intake flow has been investigated through 16 separate computational and experimental campaigns conducted by Gulfstream, NASA Glenn Research Center, University of Illinois, Purdue University, and the University of Virginia. The culmination of the experimental work has been full-scale ground testing at Gulfstream using a Rolls-Royce Tay turbofan engine and, more recently, large-scale model testing at speeds to Mach 1.8 at NASA Glenn’s 8-by-6 ft wind tunnel. Excellent static and supersonic inlet performance was recorded during these tests, with outstanding robustness against crossflow effects. Buzz margin was large, and bypass flow pumping was shown to be stable and predictable at supersonic speeds. Selected results are presented in this report along with a summary of the development history of the bypass concept, with an emphasis on the work accomplished in the 8-by-6 ft tunnel. Results from six years of research and over twenty technical publications indicate that high-flow nacelle bypass is a feasible and valuable addition to the growing set of tools available for ultra-low sonic boom aircraft design.
3-D reconstruction of the human jaw using space carving (2002)

This paper presents a model-based vision system for dentistry that will assist in diagnosis, treatment planning and surgical simulation. Dentistry requires an accurate 3D representation of the teeth and jaws for diagnostic and treatment purposes. The proposed integrated computer vision system constructs a 3D model of the patient's dental occlusion using an intra-oral video camera. The space carving algorithm is used to reconstruct the shape of the human jaw. This algorithm provides more flexibility and eliminates several constraints imposed by other approaches like stereo. The system performance is investigated, and the results show acceptable reconstruction accuracy.
A simulation framework for aircraft power management (2008)

Today, the preliminary design process of power system architectures of civil aircraft is characterized by the separation into air transport association chapters. However, the complexity of an aircraft energy network and the large number of influencing design parameters and system interfaces require a common and transparent process if one is aiming at a meaningful evaluation of different system architectures with regard to overall aircraft efficiency. The variety of possible solutions requires a flexible tool that enables the system designer or aircraft architect to analyse the impact of system architecture changes at the aircraft level and the impact of aircraft level changes on system design. The outline of a simulation framework that fits these needs is presented in this paper.
Antimicrobial Peptides: A Potential Therapeutic Option for Surgical Site Infections. (2017)

Surgical Site Infections (SSI) represents one of the most common hospital-associated infections worldwide, and many cases of SSI are due to multidrug-resistant bacteria with the propensity to attach to tissues and form biofilm on post-surgical sites. While systemic antibiotic treatment (prophylactically and therapeutically) is usually effective, SSI can be difficult to treat when associated with drug resistance. Antimicrobial Peptides (AMPs) are an untapped resource that could serve as an effective therapeutic option, as they display broad-spectrum antimicrobial activity regardless of antibiotic resistance. In the last decade, it has become increasingly clear that AMPs also display antibiofilm properties. We reviewed herein the potential of AMPs as promising therapeutics for SSI and the need for structural optimization to develop AMPs for clinical applications.
Quantitative Imaging of Cerebral Thromboemboli In Vivo (2017)

Thromboembolic burden and the efficacy of tPA therapy can be assessed serially, noninvasively, and quantitatively using high-resolution microcomputed tomography and a fibrin-binding nanoparticle imaging agent.
Galectin-8 Functions as a Matricellular Modulator of Cell Adhesion (2001)

The interaction of cells with the extracellular matrix regulates cell adhesion and motility. Here we demonstrate that different cell types adhere and spread when cultured in serum-free medium on immobilized galectin-8, a mammalian beta-galactoside-binding protein. At maximal doses, galectin-8 is equipotent to fibronectin in promoting cell adhesion and spreading. Cell adhesion to immobilized galectin-8 is mediated by sugar-protein interactions with integrins, and galectin-8 triggers integrin-mediated signaling cascades including Tyr phosphorylation of focal adhesion kinase and paxillin. Cell adhesion is potentiated in the presence of Mn(2+), whereas it is interrupted in the presence of soluble galectin-8, integrin beta(1) inhibitory antibodies, EDTA, or thiodigalactoside but not by RGD peptides. Furthermore, cells readily adhere onto immobilized monoclonal galectin-8 antibodies, which are equipotent to integrin antibodies in promoting cell adhesion. Cell adhesion to immobilized galectin-8 is partially inhibited by serum proteins, suggesting that complex formation between immobilized galectin-8 and serum components generates a matrix that is less supportive of cell adhesion. Accordingly, cell motility on immobilized galectin-8 readily takes place in the presence of serum. Truncation of the C-terminal half of galectin-8, including one of its two carbohydrate recognition domains, largely abolishes its ability to modulate cell adhesion, indicating that both carbohydrate recognition domains are required to maintain a functional form of galectin-8. Collectively, our findings implicate galectin-8 as a physiological modulator of cell adhesion. When immobilized, it functions as a matrix protein equipotent to fibronectin in promoting cell adhesion by ligation and clustering of cell surface integrin receptors. In contrast, when present in excess as a soluble ligand, galectin-8 (like fibronectin) forms a complex with integrins that negatively regulates cell adhesion. Because of its dual effects on the adhesive properties of the cells and its association with fibronectin, galectin-8 might be considered a novel type of matricellular protein.
Diversifying Biological Fuel Cell Designs by Use of Nanoporous Filters (2007)

The use of proton exchange membranes (PEMs) in biological fuel cells limits the diversity of novel designs for increasing output power or enabling autonomous function in unique environments. Here we show that selected nanoporous polymer filters (nylon, cellulose, or polycarbonate) can be used effectively in place of PEMs in a miniature microbial fuel cell (mini-MFC, device cross-section 2 cm2), generating a power density of 16 W/m3 with an uncoated graphite felt oxygen reduction reaction (ORR) cathode. The incorporation of polycarbonate or nylon membranes into biological fuel cell designs produced comparable power and durability to Nafion-117 membranes. Also, high power densities for novel larger (5 cm3 anode volume, 0.6 W/m3) and smaller (0.025 cm3 projected geometric volume, average power density 10 W/m3) chamberless and pumpless microbial fuel cells were observed. As an additional benefit, the nanoporous membranes isolated the anode from invading natural bacteria, increasing the potential applications for MFCs beyond aquatic sediment environments. This work is a practical solution for decreasing the cost of biological fuel cells while incorporating new features for powering long-term autonomous devices.
Modulation of in vivo 3-deoxyglucosone levels (2003)

Fructoselysine 3-phosphate is synthesized in vivo by the recently discovered fructoseamine-3-kinase (F3K) from fructoselysine and ATP and decomposes to lysine, P(i) and 3-deoxyglucosone (3DG). This pathway appears to dominate 3DG production in vivo, making it possible to modulate 3DG levels by stimulating or inhibiting the reaction. Present inhibitors are non-reacting substrate analogues with relatively high K (i) values and can inhibit F3K sufficiently in vivo to reduce 3DG in diabetic rat plasma by approx. 50%. Stimulation of the F3K pathway by feeding glycated casein causes an increase of 10-20-fold in plasma levels of 3DG and 3-fold in kidney tubules. Consequences of this increase were studied in two systems: the Eker rat, a model of susceptible kidney tubules; and birth rates in two rat strains. In both cases substantial pathological effects were observed. In the Eker rats, an approx. 3-fold increase in kidney lesions was observed ( P <0.00001). In both Fischer 344 and Sprague-Dawley rats, birth rates were reduced by 56% ( P <0.0001) and 12% ( P <0.015) respectively. These results suggest that inhibition of F3K is a promising new therapeutic target for diabetic complications, as well as other 3DG-dependent pathologies.
FT-1101: A Structurally Distinct Pan-BET Bromodomain Inhibitor with Activity in Preclinical Models of Hematologic Malignancies (2015)

Abstract Members of the Bromodomain and Extra-Terminal (BET) family of bromodomain-containing proteins (BRD2, BRD3, BRD4, and BRDT) bind to acetylated lysine residues on histone tails and act as epigenetic readers to regulate chromatin structure and gene expression. In particular, BET family member BRD4 has been shown to positively regulate the expression of MYC and other critical cancer-associated genes through the localization of BRD4 to super-enhancer regulatory elements. Results from preclinical studies conducted using the small molecule tool BET inhibitor (+)-JQ1, and emerging data from clinical trials of BET inhibitors in leukemia and lymphoma patients, have provided support for the therapeutic potential of BET inhibitors in hematologic malignancies. A protein structure-guided drug design approach was employed to explore small molecule acetyl lysine mimetics and led to the identification of the BET inhibitor FT-1101, which is structurally unrelated to reported clinical-stage BET inhibitors in the (+)-JQ1 class. In biochemical binding assays, FT-1101 displayed equipotent inhibition of binding of both bromodomains in all four BET family members to a known bromodomain ligand (Kd ≤ 20 nM). In vitro, FT-1101 displayed potent anti-proliferative activity across a broad panel of human leukemia, lymphoma, and multiple myeloma cell lines, with 66 out of 123 cell lines having IC50 values < 500 nM. For the MV-4-11 acute myeloid leukemia cell line, the anti-proliferative activity of FT-1101 (IC50 = 40 nM) correlated with down-regulation of MYC gene and protein expression, suggesting that its anti-proliferative activity was at least in part due to suppression of MYC. Additionally, genome-wide mapping of BRD4 super-enhancer binding sites in MV-4-11 cells by ChIP-sequencing identified several potential pharmacodynamic biomarkers outside of the MYC signaling network. In vivo, in the MV-4-11 xenograft model, oral treatment with FT-1101 at its maximum tolerated dose resulted in significant tumor growth inhibition, including tumor regressions, on schedules ranging from once daily to once weekly, and similar activity was also observed in the THP-1 AML xenograft model. Superior in vivo efficacy in the MV-4-11 model was observed for FT-1101 relative to BET inhibitors of the (+)-JQ1 class. In vivo efficacy was associated with prolonged drug exposure and a >75% decrease in MYC gene expression in tumors that was sustained for at least 12 hours. FT-1101 also crossed the blood-brain barrier in mice, achieving a pharmacologically relevant free drug concentration in the brain. The promising preclinical profile of FT-1101 warranted its rapid progression into human clinical trials, and a Phase 1 study in patients with relapsed refractory acute leukemia or high-risk myelodysplastic syndrome is currently underway. Disclosures No relevant conflicts of interest to declare.
Energy and Exergy Analyses of Recompression Brayton Cycles Integrated with a Solar Power Tower through a Two-Tank Thermal Storage System (2018)

Energy and exergy analyses of a recompression supercritical carbon dioxide Brayton cycle integrated with a solar tower through a two-tank thermal storage system were conducted. A complete mathematical model, where a heliostat field was deployed and annually optimized is presented. This optimized heliostat field was then integrated with the supercritical carbon dioxide (sCO2) recompression Brayton cycle through a two-tank thermal storage system. Finally, exergy analysis was conducted for the entire integrated system. Molten salt was used as the medium in the storage tanks, and the analysis was performed for June 11, March 16, and December 10. The analysis was conducted for each complete day so that the storage system operated for 24 h without the need for any auxiliary heat source irrespective of the net power output of the integrated system. It was concluded that the highest and the lowest exergy destruction occurred in the central receiver system and the thermal storage system, respectively. For the month of June, the exergy destruction rate for the heliostat field and the solar tower is 1,295,605 and 156,254 kWh/day, respectively, which together constitute the total exergy destruction of the central receiver. In addition, the combined exergy destruction of all the components of supercritical carbon dioxide Brayton cycle is 138,432 kWh/day, and for thermal storage the exergy destruction rate is 4,735 kWh/day. Furthermore, the net energy efficiency of the whole system at solar noon for the month of June, March, and December is 6.93, 5.71, and 4.45%, respectively. Lastly, the electrical second law efficiency is 7.44, 6.14, and 5.04% for the months of June, March, and December, respectively. This analysis was conducted for Dhahran, Saudi Arabia, as an illustrative example of the developed model.
Sex pheromone of the pink hibiscus mealybug, <i>Maconellicoccus hirsutus</i> , contains an unusual cyclobutanoid monoterpene (2004)

Two compounds that together constitute the female sex pheromone of the pink hibiscus mealybug (PHM), Maconellicoccus hirsutus, were isolated, identified, and synthesized. They are (R)-2-isopropenyl-5-methyl-4-hexenyl (S)-2-methylbutanoate [common name is (R)-lavandulyl (S)-2-methylbutanoate] and [(R)-2,2-dimethyl-3-(1-methylethylidene)cyclobutyl]methyl (S)-2-methylbutanoate [which we refer to as (R)-maconelliyl (S)-2-methylbutanoate]. Maconelliol is an unusual cyclobutanoid monoterpene, and its structure has been established by enantioselective synthesis from precursors of known structure and configuration. A 1:5 synthetic mixture of the two RS esters (1 microg per rubber septum) proved to be a potent attractant of males in field bioassays. The pheromone component, maconelliyl 2-methylbutanoate, represents a heretofore undescribed natural product.
High-power Al-free active-region diode lasers (1998)

Al-free InGaAsP/InGaP/GaAs-based diode lasers in the wavelength range 730 - 980 nm have been grown by metalorganic chemical vapor deposition (MOCVD). A large transverse spot size is obtained using a Broad Waveguide (BW) design, permitting record output powers to be obtained.
Increased Rhamnolipid Concentration and Productivity Achieved with Advanced Process Design (2020)

Abstract Rhamnolipids are biosurfactants having several applications. A major limitation in rhamnolipid production is low productivity, which decreases significantly during stationary‐phase production. In this study, fermentations were first made with nitrogen‐limited stationary phase. Long‐term rhamnolipid production (up to 505 h) could be maintained with low‐rate N‐source addition but the intermittent cell growth led to lower productivity (q p ), particularly apparent at the highest addition rate. Four fermentations were next made under non‐N‐limited stationary phase without and with N‐source supplementation; q p could be much higher at 24–26 mg g −1 h −1 . Three final fermentations were designed to build the maximum cell concentration to 30 g L −1 in two growth phases where the growth rate in the second phase was regulated by N‐addition to control foaming. Cultures then entered non‐N‐limited stationary phase and were N‐supplemented. At an optimal rate of 15% growth‐N per 24 h to maintain cell activity, a highest rhamnolipid concentration of 120 g L −1 was obtained after 144 h with overall productivity of 839 mg L −1 h −1 .
Comparison of Discrete-Fracture and Dual-Permeability Models for Multiphase Flow in Naturally Fractured Reservoirs (2011)

Abstract Two discrete-fracture models (DFMs) based on different, independent numerical techniques have been developed for studying the behavior of naturally fractured reservoirs. One model is based on unstructured gridding with local refinement near fractures, while in the second model fractures are embedded in a structured matrix grid. Both models capture the complexity of a typical fractured reservoir better than conventional dual-permeability models, leading to a more accurate representation of fractured reservoirs. The accuracy of the DFM approaches is confirmed by their match with a structured, grid-aligned, explicit-fracture model in tests involving capillary imbibition during water flooding and gravity drainage in oil-gas systems. The DFMs are insensitive to grid orientation. Simulations also show consistency and agreement of results of the DFM methods in synthetic models with complex fracture patterns. Our simulations indicate that conventional dual-permeability approaches are appropriate when the fracture system is very sparse relative to the grid spacing. In these situations a DFM can be used as the basis for defining dual-permeability model parameters. However, conventional dual-permeability approaches are inadequate in the presence of high localized anisotropy and preferential channeling. When used with general purpose reservoir simulators, both DFMs show computational performance that is comparable to that of dual-permeability models.
Radiation curable conductive ink (1977)

General Electric has developed a photoflash array with many new features of technological interest. These include a new piezo-electric high voltage ignition system, a new lamp design with no filament, a radiation triggered switch, and a novel, low cost circuit board.
Algorithm design of a stereophonic acoustic echo canceler system (2002)

A software program has been designed that successfully runs a stereophonic acoustic echo canceler natively on a personal computer. This is a major achievement since an echo canceler requires that the soundcard's input and output signals are time-synchronous. Synchronizing the audio streams is a great challenge in such an "asynchronous" environment as the operating system of a PC. Furthermore, stereophonic echo cancellation is significantly more complicated to handle than the monophonic case because of computational complexity, nonuniqueness, and convergence problems. Special care has to be taken in the algorithm design. This work presents the core algorithms, i.e., the adaptive algorithm and the double-talk detection algorithm of the implemented echo canceler.
Hard-disk-drive technology flat heads for linear tape recording (2003)

IBM thin-film tape heads have evolved from the ferrite-based heads first used in the IBM Model 3480 Tape Drive to the hard-disk-drive (HDD) technology flat-profile heads used in IBM Linear Tape-Open® (LTO®) products. This paper describes that transition and discusses the flat tape head manufacturing processes, drive implementation, performance, and outlook. Thin-film head technology for hard-disk drives was first used in tape heads in the early 1990s, when IBM built quarter-inch cartridge head images on HDD-type wafers. This was a springboard for the next step, flat-lapped tape heads, which use not only HDD wafers, but also HDD post-wafer machining technologies. With the emergence of LTO, flat heads entered mainstream tape head production in IBM. These have proven to have high performance and durability.
Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs (2010)

Ingestion of the test food raised blood concentrations of omega-3 fatty acids and appeared to improve the arthritic condition in pet dogs with osteoarthritis.
Session Description Protocol (SDP) Media Capabilities Negotiation (2013)

Session Description Protocol (SDP) capability negotiation provides a general framework for indicating and negotiating capabilities in SDP.The base framework defines only capabilities for negotiating transport protocols and attributes.This documents extends the framework by defining media capabilities that can be used to negotiate media types and their associated parameters.