gebhart/patrepeval huggingface dataset:
Chemistry and Biochemistry of (−)-Hydroxycitric Acid from <i>Garcinia</i> (2001)

(-)-Hydroxycitric acid [(-)-HCA] is the principal acid of fruit rinds of Garcinia cambogia, Garcinia indica, and Garcinia atroviridis. (-)-HCA was shown to be a potent inhibitor of ATP citrate lyase (EC 4.1.3.8), which catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA: citrate + ATP + CoA --> acetyl-CoA + ADP + P(i) + oxaloacetate. The inhibition of this reaction limits the availability of acetyl-CoA units required for fatty acid synthesis and lipogenesis during a lipogenic diet, that is, a diet high in carbohydrates. Extensive animal studies indicated that (-)-HCA suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss. In vitro studies revealed the inhibitions of fatty acid synthesis and lipogenesis from various precursors. However, a few clinical studies have shown controversial findings. This review explores the literature on a number of topics: the source of (-)-HCA; the discovery of (-)-HCA; the isolation, stereochemistry, properties, methods of estimation, and derivatives of (-)-HCA; and its biochemistry, which includes inhibition of the citrate cleavage enzyme, effects on fatty acid synthesis and lipogenesis, effects on ketogenesis, other biological effects, possible modes of action on the reduction of food intake, promotion of glycogenesis, gluconeogenesis, and lipid oxidation, (-)-HCA as weight-controlling agent, and some possible concerns about (-)-HCA, which provides a coherent presentation of scattered literature on (-)-HCA and its plausible mechanism of action and is provocative of further research.
Anti‐inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor (1994)

1. We have investigated the effects of RP 73401, a novel, potent and highly selective cyclic nucleotide phosphodiesterase (PDE) type IV inhibitor, in guinea-pig and rat models of bronchoconstriction and allergic inflammation. In some models, the effects of RP 73401 have been compared with those of the standard PDE type IV inhibitor, rolipram. 2. RP 73401 (0.4-400 micrograms kg-1, intratracheally (i.t.) on lactose) inhibited antigen-induced bronchospasm in previously sensitized conscious guinea-pigs (ID50: 7 +/- 1 micrograms kg-1) and in anaesthetized rats (ID50: 100 +/- 25 micrograms kg-1). Rolipram inhibited the antigen-induced bronchospasm in guinea-pigs with an ID50 of 5 +/- 1 micrograms kg-1. In guinea-pig bronchoalveolar lavage (BAL) fluid, total inflammatory cell and eosinophil numbers were reduced by RP 73401 (ID50s: 3.9 +/- 0.8 micrograms kg-1 and 3.2 +/- 0.7 micrograms kg-1, respectively). In the rat, inflammatory cell numbers are less affected. Only the highest dose of RP 73401 (400 micrograms kg-1) significantly inhibited eosinophil influx (41 +/- 16% inhibition). 3. RP 73401 (0.02-100 micrograms kg-1, i.v.) inhibited PAF-induced bronchial hyperreactivity to bombesin in the anaesthetized guinea-pig (ID50: 0.09 +/- 0.03 micrograms kg-1) and inhibited (0.4-40 micrograms kg-1, i.t.) histamine-induced airway microvascular leakage in the anaesthetized guinea-pig by approximately 60% at all doses. 4. RP 73401 relaxed guinea-pig isolated trachea under basal tone (EC50: 9 nM) and when precontracted with histamine (IC50: 2 nM), methacholine (IC50: 29 nM) or leukotriene D4 (LTD4, IC50: 4 nM). 5. RP 73401 (0.4-100 microg kg-1, i.t.) inhibited bronchospasm induced by histamine (ID.%: 34 +/- 6 microg kg-1), methacholine (ID50: 66 +/- 12 pg kg-1) and LTD4 (ID50: <4 microg kg-1) in the anaesthetized guinea pig.Against these same bronchoconstrictors, rolipram (i.t.) had ID5o values of 44 +/- 4, 72 +/- 18 and<4 pg kg- respectively. RP 73401 (4 and 40 pg kg-, i.t.) increased the magnitude and duration of bronchodilatation produced by salbutamol in the anaesthetized guinea-pig. At doses producing significant bronchodilatation, RP 73401 was without effect on heart rate or blood pressure in the anaesthetized guinea-pig. RP 73401 (0.01 -0.25 mg kg-1, i.v.) did not affect heart rate and produced only a small fall in blood pressure in the anaesthetized rat.6. These data demonstrate that RP 73401 and rolipram inhibit antigen- and mediator-induced bronchospasmin guinea-pigs with the same potency. Furthermore, RP 73401 administered directly into the airways, protects against allergic airway inflammation. These results indicate the importance of PDE IV in regulating smooth muscle and inflammatory cell activity. At doses suppressing the inflammatory response in the lung, RP 73401 had little effect in the cardiovascular system. RP 73401 may have a role as a bronchodilator and, more importantly, as a prophylactic anti-inflammatory agent in the treatment of asthma.
Improved LC−MS Method for the Determination of Fatty Acids in Red Blood Cells by LC−Orbitrap MS (2011)

We report a new method for fast and sensitive analyses of biologically relevant fatty acids (FAs) in red blood cells (RBC) by liquid chromatography mass spectrometry (LC-MS). A new chemical derivatization approach was developed forming picolylamides from FAs in a quantitative reaction. Fourteen derivatized FA standards, including saturated and unsaturated FAs from C14 to C22, were efficiently separated within 15 min. In addition, the use of a recently introduced benchtop orbitrap mass spectrometer under positive electrospray ionization (ESI) full scan mode showed a 2-10-fold improvement in sensitivity compared with a conventional tandem MS method, with a limit of detection in the low femtomole range for saturated and unsaturated FAs. The developed method was applied to determine FA concentrations in RBC with intra- and interday coefficients of variation below 10%.
A new frame‐based registration algorithm (1998)

This paper presents a new algorithm for frame registration. Our algorithm requires only that the frame be comprised of straight rods, as opposed to the N structures or an accurate frame model required by existing algorithms. The algorithm utilizes the full 3D information in the frame as well as a least squares weighting scheme to achieve highly accurate registration. We use simulated CT data to assess the accuracy of our algorithm. We compare the performance of the proposed algorithm to two commonly used algorithms. Simulation results show that the proposed algorithm is comparable to the best existing techniques with knowledge of the exact mathematical frame model. For CT data corrupted with an unknown in-plane rotation or translation, the proposed technique is also comparable to the best existing techniques. However, in situations where there is a discrepancy of more than 2 mm (0.7% of the frame dimension) between the frame and the mathematical model, the proposed technique is significantly better (p < or = 0.05) than the existing techniques. The proposed algorithm can be applied to any existing frame without modification. It provides better registration accuracy and is robust against model mis-match. It allows greater flexibility on the frame structure. Lastly, it reduces the frame construction cost as adherence to a concise model is not required.
On the Relationship Between Robust Minimum Variance Beamformers With Probabilistic and Worst-Case Distortionless Response Constraints (2008)

An interesting relationship between the probability-constrained and worst-case optimization based robust minimum variance (MV) beamformers has been discovered. It is shown that both in the cases of circularly symmetric Gaussian and worst-case distributions of the steering vector mismatch, the probability-constrained robust MV beamforming problem can be tightly approximated as a convex second-order cone programming (SOCP) problem. The latter problem is mathematically equivalent to that resulting from the deterministic worst-case approach and, therefore, probability-constrained beamformers can be interpreted and implemented using their deterministic worst-case counterparts. However, an important advantage of the developed probability-constrained MV beamformers with respect to their standard worst-case counterparts is that the former approaches enable to explicitly quantify the parameters of the uncertainty region in terms of the beamformer outage probability.
Intimin-dependent binding of enteropathogenic Escherichia coli to host cells triggers novel signaling events, including tyrosine phosphorylation of phospholipase C-gamma1 (1997)

Enteropathogenic Escherichia coli (EPEC) interactions with HeLa epithelial cells induced the tyrosine phosphorylation of a host protein of approximately 150 kDa, Hp150. Phosphorylation of this protein band was dependent on the interaction of the EPEC protein intimin with epithelial cell surfaces and was correlated with pedestal formation. Hp150 phosphorylation was specifically inhibited by the addition of cytochalasin D, an inhibitor of actin polymerization, although this appeared to be an indirect effect preventing interaction of intimin with its receptor, tyrosine-phosphorylated Hp90, and thus triggering Hp150 phosphorylation. This suggests the involvement of an actin-based movement of membrane-bound tyrosine-phosphorylated Hp90 to allow its interaction with intimin. Analysis of the tyrosine-phosphorylated Hp150 protein demonstrated that it is heterogeneous in composition, with phospholipase C-gamma1 (PLC-gamma1) being a minor component. Activation of PLC-gamma1 by tyrosine phosphorylation leads to inositol triphosphate and Ca2+ fluxes, events detected following EPEC infection. EPEC also induced tyrosine dephosphorylation of host proteins, including a 240-kDa host protein (Hp240), following EPEC infection. Protein dephosphorylation appears to be a signaling event which occurs independently of intimin. Inhibition of host tyrosine dephosphorylation events by the addition of the tyrosine phosphatase inhibitor sodium vanadate did not prevent actin accumulation beneath the adherent bacteria. We conclude that EPEC induces two sets of signaling events following infection. One set is dependent on EPEC proteins secreted by the type III secretion pathway (EspA and EspB) which induces Hp90 tyrosine phosphorylation and dephosphorylation of host phosphotyrosine proteins. The second set, which is also dependent on the first signaling events, requires intimin interaction with its receptor, tyrosine-phosphorylated Hp90, to trigger Hp150 and PLC-gamma1 tyrosine phosphorylation as well as pedestal formation. Inhibition of pedestal formation by tyrosine kinase inhibitors indicates an important role for tyrosine phosphorylation events during EPEC subversion of host processes.
Distilled Sensing: Adaptive Sampling for Sparse Detection and Estimation (2010)

Adaptive sampling results in dramatic improvements in the recovery of sparse signals in white Gaussian noise. A sequential adaptive sampling-and-refinement procedure called Distilled Sensing (DS) is proposed and analyzed. DS is a form of multi-stage experimental design and testing. Because of the adaptive nature of the data collection, DS can detect and localize far weaker signals than possible from non-adaptive measurements. In particular, reliable detection and localization (support estimation) using non-adaptive samples is possible only if the signal amplitudes grow logarithmically with the problem dimension. Here it is shown that using adaptive sampling, reliable detection is possible provided the amplitude exceeds a constant, and localization is possible when the amplitude exceeds any arbitrarily slowly growing function of the dimension.
Multiple Radios for Fast Rendezvous in Cognitive Radio Networks (2014)

Rendezvous is a fundamental operation in cognitive radio networks (CRNs) for establishing a communication link on a commonly-available channel between cognitive users. The existing work on rendezvous implicitly assumes that each cognitive user is equipped with one radio (i.e., one wireless transceiver). As the cost of wireless transceivers is dropping, this feature can be exploited to significantly improve the rendezvous performance at low cost. In this study, we investigate the rendezvous problem in CRNs where cognitive users are equipped with multiple radios and different users may have different numbers of radios. We first study how the existing rendezvous algorithms can be generalized to use multiple radios for faster rendezvous. We then propose a new rendezvous algorithm, called role-based parallel sequence (RPS), which specifically exploits multiple radios for more efficient rendezvous. Our basic idea is to let the cognitive users stay in a specific channel in one dedicated radio and hop on the available channels with parallel sequences in the remaining general radios. We prove that our algorithm provides guaranteed rendezvous (i.e., rendezvous can be completed within a finite time) and derive the upper bounds on the maximum time-to-rendezvous (TTR) and the expected TTR. The simulation results show that i) multiple radios can cost-effectively improve the rendezvous performance, and ii) the proposed RPS algorithm performs better than the ones generalized from the existing algorithms.
Room‐Temperature Nanosoldering of a Very Long Metal Nanowire Network by Conducting‐Polymer‐Assisted Joining for a Flexible Touch‐Panel Application (2013)

Abstract As an alternative to the brittle and expensive indium tin oxide (ITO) transparent conductor, a very simple, room‐temperature nanosoldering method of Ag nanowire percolation network is developed with conducting polymer to demonstrate highly flexible and even stretchable transparent conductors. The drying conducting polymer on Ag nanowire percolation network is used as a nanosoldering material inducing strong capillary‐force‐assisted stiction of the nanowires to other nanowires or to the substrate to enhance the electrical conductivity, mechanical stability, and adhesion to the substrate of the nanowire percolation network without the conventional high‐temperature annealing step. Highly bendable Ag nanowire/conducting polymer hybrid films with low sheet resistance and high transmittance are demonstrated on a plastic substrate. The fabricated flexible transparent electrode maintains its conductivity over 20 000 cyclic bends and 5 to 10% stretching. Finally, a large area (A4‐size) transparent conductor and a flexible touch panel on a non‐flat surface are fabricated to demonstrate the possibility of cost‐effective mass production as well as the applicability to the unconventional arbitrary soft surfaces. These results suggest that this is an important step toward producing intelligent and multifunctional soft electric devices as friendly human/electronics interface, and it may ultimately contribute to the applications in wearable computers.
Acoustic spin pumping: Direct generation of spin currents from sound waves in Pt/Y3Fe5O12 hybrid structures (2012)

Using a Pt/Y3Fe5O12 (YIG) hybrid structure attached to a piezoelectric actuator, we demonstrate the generation of spin currents from sound waves. This “acoustic spin pumping” (ASP) is caused by the sound wave generated by the piezoelectric actuator, which then modulates the distribution function of magnons in the YIG layer and results in a pure-spin-current injection into the Pt layer across the Pt/YIG interface. In the Pt layer, this injected spin current is converted into an electric voltage due to the inverse spin-Hall effect (ISHE). The ISHE induced by the ASP is detected by measuring a voltage in the Pt layer at the piezoelectric resonance frequency of the actuator coupled with the Pt/YIG system. The frequency-dependent measurements enable us to separate the ASP-induced signals from extrinsic heating effects. Our model calculation based on the linear response theory provides us with a qualitative and quantitative understanding of the ASP in the Pt/YIG system.
Federated Identity Access Broker Pattern for Cloud Computing (2013)

With the adoption of cloud computing, a multitude of front-end mobile devices are emerging that require access to services in the cloud. Applications in the cloud are now commonly deployed as software as a service (SaaS). However, with the introduction of SaaS new security challenges need to be addressed. The challenge is to provide a single sign-on environment for services through an identity provider plus sufficient authorization granularity for backend services for the client applications to access. Through detailed discussion of the two standards (SAML 2.0 and OAuth 2.0) this paper presents a study how the two standards can provide a single sign-on solution for cloud computing. Furthermore, by outlining a case study/scenario of the two standards, the Federated Identity Access Broker Pattern for cloud computing is developed to present a solution for these security issues.
ChemInform Abstract: Peptide Structure from NMR (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Crystal Engineering of Molecular Solids as Temporary Adhesives (2020)

Crystal engineering of temporary adhesion is important in diverse fields ranging from healthcare to manufacturing. Molecular solids—a broad class of crystalline materials characterized by discrete molecules with well-defined chemical and crystal structures—can be utilized as sublimable adhesives to achieve rapid adhesion, strong mechanical bonding, and facile on-demand release of surfaces. Through systematic investigation of the interfacial and bulk properties of molecular solids, this paper shows that this class of materials can exhibit remarkable mechanical strength (resistance to shear stress up to 2100 kPa and shear strain up to 37, as well as shear moduli up to 1000 kPa) yet enable on-demand (within minutes) release from adhesion through controlled sublimation without the application of solvents and/or mechanical force. Intermolecular interactions heavily influence the mechanical performance via preferential orientation of the solid relative to surfaces during the melt-bonding process. This research quantifies how chemical and crystal structures inform macroscopic mechanical properties of polycrystalline solids.
Monitoring Vital Signs and Postures During Sleep Using WiFi Signals (2018)

Tracking human sleeping postures and vital signs of breathing and heart rates during sleep is important as it can help to assess the general physical health of a person and provide useful clues for diagnosing possible diseases. Traditional approaches (e.g., polysomnography) are limited to clinic usage. Recent radio frequency-based approaches require specialized devices or dedicated wireless sensors and are only able to track breathing rate. In this paper, we propose to track the vital signs of both breathing rate and heart rate during sleep by using off-the-shelf WiFi without any wearable or dedicated devices. Our system reuses existing WiFi network and exploits the fine-grained channel information to capture the minute movements caused by breathing and heart beats. Our system thus has the potential to be widely deployed and perform continuous long-term monitoring. The developed algorithm makes use of the channel information in both time and frequency domain to estimate breathing and heart rates, and it works well when either individual or two persons are in bed. Our extensive experiments demonstrate that our system can accurately capture vital signs during sleep under realistic settings, and achieve comparable or even better performance comparing to traditional and existing approaches, which is a strong indication of providing noninvasive, continuous fine-grained vital signs monitoring without any additional cost.
Articular Cartilage Repair: Potential Role of Growth and Differentiation Factors (2022)

Osteoarthritis is the most common of the various arthritic disorders. The tissues involved in this slow and destructive process are mainly articular cartilage and subchondral bone. While it is well known that bone has an impressive potential for regeneration, cartilage is considered to have a limited capacity for repair. Thus, the study of the biological basis of cartilage repair and regeneration is a scientific challenge with direct implications for potential therapeutic approaches for resurfacing of joints. This chapter presents a concise current status and explores potential future approaches. The bovine articular cartilage explant culture system is a useful model to study the mechanisms underlying homeostasis. The growing information on the processes of cellular proliferation and acquisition of the specialized phenotype has triggered the interest of both clinicians and basic scientists. It has become evident that tissue regeneration recapitulates the developmental sequences of tissue formation.
Excited Composition of Primary Side in a Position-Free Contactless Power Station System. (2002)

We propose a desk-type design for a contactless power station (CLPS) using spiral formed coils. In this system, in order to supply electrical power efficiently to portable equipment on the desk, the primary coils are arranged to cover the desk. A configuration using several primary coils for each secondary coil was therefore proposed. We examined improvement of transmitted characteristics in this coil configuration. We improved transmitted characteristics of the electric supply and charging circuit to book-size personal computer as an applied example. As a result, we confirmed we kept the efficiency high of electric power transmission everywhere. From this fact, we confirmed the effectiveness of using several primary coils.
Predicting Channel Quality Indicators for 5G Downlink Scheduling in a Deep Learning Approach (2020)

5G networks provide more bandwidth and more complex control to enhance user's experiences, while also requiring a more accurate estimation of the communication channels compared with previous mobile networks. In this paper, we propose a channel quality indicator (CQI) prediction method in a deep learning approach in that a Long Short-Term Memory (LSTM) algorithm. An online training module is introduced for the downlink scheduling in the 5G New Radio (NR) system, to reduce the negative impact of outdated CQI for communication degradation, especially in high-speed mobility scenarios. First, we analyze the impact of outdated CQI in the downlink scheduling of the 5G NR system. Then, we design a data generation and online training module to evaluate our prediction method in ns-3. The simulation results show that the proposed LSTM method outperforms the Feedforward Neural Networks (FNN) method on improving the system performance of the downlink transmission. Our study may provide insights into designing new deep learning algorithms to enhance the network performance of the 5G NR system.
Infrared optical parametric oscillator in potassium titanyl phosphate (1989)

An infrared optical parametric oscillator using potassium titanyl phosphate (KTP) pumped by a 1.06- mu m Nd:YAG laser is discussed. Oscillation was obtained around the degenerate wavelength at 2.12 mu m with a pump threshold of 40 MW/cm/sup 2/ in a 30-ns pulse. Difference frequency generation with an output at 2.4 mu m was also obtained between inputs at 1.06 and 1.9 mu m. The broad tuning range and high damage resistance of KTP make this an important new source of tunable infrared radiation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>