gebhart/patrepeval huggingface dataset:
Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines (2006)

Type 1 diabetes results from islet beta-cell death and dysfunction induced by an autoimmune mechanism. Proinflammatory cytokines such as interleukin-1beta and gamma-interferon are mediators of this beta-cell cytotoxicity, but the mechanism by which damage occurs is not well understood. In the current study, we present multiple lines of evidence supporting the conclusion that cytokine-induced killing of rat beta-cells occurs predominantly by a nonapoptotic mechanism, including the following: 1) A rat beta-cell line selected for resistance to cytokine-induced cytotoxicity (833/15) is equally sensitive to killing by the apoptosis-inducing agents camptothecin and etoposide as a cytokine-sensitive cell line (832/13). 2) Overexpression of a constitutively active form of the antiapoptotic protein kinase Akt1 in 832/13 cells provides significant protection against cell killing induced by camptothecin and etoposide but no protection against cytokine-mediated damage. 3) Small interfering RNA-mediated suppression of the proapoptotic protein Bax enhances viability of 832/13 cells upon exposure to the known apoptosis-inducing drugs but not the inflammatory cytokines. 4) Exposure of primary rat islets or 832/13 cells to the inflammatory cytokines causes cell death as evidenced by the release of adenylate kinase activity into the cell medium, with no attendant increase in caspase 3 activation or annexin V staining. In contrast, camptothecin- and etoposide-induced killing is associated with robust increases in caspase 3 activation and annexin V staining. 5) Camptothecin increases cellular ATP levels, whereas inflammatory cytokines lower ATP levels in both beta-cell lines and primary islets. We conclude that proinflammatory cytokines cause beta-cell cytotoxicity primarily through a nonapoptotic mechanism linked to a decline in ATP levels.
Differential Cytotoxicity and Particle Action of Hydroxyapatite Nanoparticles in Human Cancer Cells (2013)

Varying cytotoxicity of HAPNs was observed in different cancer cell types. Our results suggest that possible mechanisms of cytotoxicity in various types of cancer cells could be different. The elevated calcium concentration and nuclear localization of the particles might be the main mechanism of growth inhibition by HAPNs in cancer cells.
An effective approach for utilities and suppliers to assess the quality of new products before purchase (1999)

Metering technology has advanced from the basic Ferraris technology to microprocessor-controlled meters with solid state sensors and electronic register displays. The functional requirement for the microprocessor-controlled meters and modules has grown dramatically. There may be thousands of lines of software code in an electronic meter to support this additional functionality. Yet the existing type approval methods really only test the basic metering functionality. Should other arrangements be made for type approval of the software component, to reduce the risk for the purchaser of the end equipment? This paper discusses the problems faced by purchasers and manufacturers of utility equipment relying on existing type approval methods, and the philosophy which appears to be emerging from a number of national and European groups to solve some of these problems. The authors propose a cost-effective method that should address these problems for the manufacturers and provide a high degree of quality assurance to the purchasers. The paper focuses on software quality processes but a similar approach could be applied to the hardware aspects of product development. The discussion refers to revenue and payment metering as examples but the ideas proposed could be applied equally well to other products.
Mode-field expansion and reduction in dispersive fibers by local heat treatments (1999)

A novel method is proposed to make the mode-field expander and reducer using dispersive fibers which are fabricated from optical glasses with different transformation temperatures and index reductions caused by rapid cooling. The dispersive fibers are heated locally at low or high temperatures, and the index difference is decreased or increased at the heated part. The mode-field is confined weakly or strongly in the core owing to the reduced or raised index difference, and is expanded or reduced partially.
<scp>Open‐Label</scp> Phase 1 Futility Studies of Salsalate and Young Plasma in Progressive Supranuclear Palsy (2020)

Neither salsalate nor young plasma had a detectable effect on disease progression in PSP-RS. Focused open-label clinical trials incorporating historical clinical, neuropsychological, fluid, and imaging biomarkers provide useful preliminary data about the promise of novel PSP-directed therapies.
Transfer free suspended graphene devices on silicon using electrodeposited copper (2014)

Transfer free processes using Cu films greatly simplify the fabrication of reliable suspended graphene devices. In this paper, the authors report on the use of electrodeposited Cu films on Si for transfer free fabrication of suspended graphene devices. The quality of graphene layers on optimized electrodeposited Cu and Cu foil are found to be the same. By selectively etching the underlying Cu, the authors have realized by a transfer free process metal contacted, suspended graphene beams up to 50 μm in length directly on Si. The suspended graphene beams do not show any increase in defect levels over the as grown state indicating the efficiency of the transfer free process. Measured room temperature electronic mobilities of up to 5200 cm2/V·s show that this simpler and CMOS compatible route has the potential to replace the foil based route for such suspended nano and micro electromechanical device arrays.
UV photoelectron and ab initio quantum mechanical characterization of nucleotides: the valence electronic structures of 2'-deoxycytidine 5'-phosphate (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUV photoelectron and ab initio quantum mechanical characterization of nucleotides: the valence electronic structures of 2'-deoxycytidine 5'-phosphateKenzabu Tasaki, Xu Yang, Shigeyuki Urano, Sharon Fetzer, and Pierre R. LeBretonCite this: J. Am. Chem. Soc. 1990, 112, 2, 538–548Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ja00158a010https://doi.org/10.1021/ja00158a010research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comorbid anxiety moderates the relationship between depression history and prefrontal EEG asymmetry (2017)

The internalizing spectrum of psychiatric disorders-depression and anxiety-are common, highly comorbid, and challenging to treat. Individuals with childhood onset depression have a particularly poor prognosis. There is compelling evidence that individuals with depression display reduced resting-state EEG activity at sensors overlying the left prefrontal cortex, even during periods of remission, but it remains unknown whether this asymmetry is evident among individuals with a comorbid anxiety disorder. Here, we demonstrate that women with a history of childhood onset depression and no anxiety disorder (n = 37) show reduced left lateral frontal activity compared to psychiatrically healthy controls (n = 69). In contrast, women with a history of childhood onset depression and pathological levels of anxious apprehension (n = 18)-as indexed by a current generalized anxiety disorder, obsessive compulsive disorder, or separation anxiety disorder diagnosis-were statistically indistinguishable from healthy controls. Collectively, these observations suggest that anxious apprehension can mask the relationship between prefrontal EEG asymmetry and depression. These findings have implications for understanding (a) prefrontal EEG asymmetry as a neurophysiological marker of depression, (b) the comorbidity of depression and anxiety, and (c) failures to replicate the relationship between prefrontal EEG asymmetry and depression. More broadly, they set the stage for developing refined interventions for internalizing psychopathology.
野菜小規模産地の形成・再編と農協共販 : 広島県の事例 (1992)

The objective areas of this study are small-scale producing areas of vegitables in Hiroshima pref., in contrast with large-scale producing areas, e. g. Nagano pref. In Hiroshima pref., vegitable production had reduced with expansion of local cities in the 1960's, particularly at the areas nearby the city. But, in the 1970's, shipping quantity of vegitables had changed into increase because of planting vegitables to paddy fields under the Rice Production Adjustment Policy. New small-scale producing areas of vegitables have been formed in several rice producing areas. At those areas, vegitable production has been promoted by agricultural cooperatives and municipalities. Vegitable producers have shipped through agricultural cooperative to central or local wholesale markets in Hiroshima pref. But, shipping quantity has reduced again in the 1980's, because many of producers have attained old age. So, it is more necessary to get through collecting and shipping works with ease by joint shipping organization, i. e. agricultural cooperative marketing. In recent years, the roles of agricultural cooperative are more important at small-scale producing areas, that are advisory service, joint shipping, cooperative marketing, and direct transaction with consumers' cooperative.
A patient with coexisting narcolepsy and morbid jealousy showing favourable response to fluoxetine (1994)

A 37 year old Chinese man suffered from coexisting narcolepsy and morbid jealousy which were precipitated by head injury 5 years previously. Fluoxetine 20 mg/day reduced his narcoleptic symptoms and morbid jealousy but not his sleepiness. On defaulting treatment, the patient's symptoms and marital problem recurred. A common central serotonin disturbance might be involved in mediating the sleep disorder and associated psychopathology.
Rapid Control of Switchable Oil Wettability and Adhesion on the Copper Substrate (2011)

We described a facile approach to rapidly achieve the reversible oil wettability and adhesion transition on the copper substrate. Plasma treatment and surface fluorination were used to tune the surface composition, and this tunability of the surface composition, along with the stable surface roughness, gave rise to the switchable wettability varying from superoleophobicity to superoleophilicity and reversible oil adhesion between sliding superoleophobicity and sticky superoleophobicity. It took only 1.25 min to realize the whole wettability transition and 5 min for the whole adhesion transition. Additionally, the application of a sticky superoleophobic surface was demonstrated. This study represents an important addition to the field of functional superoleophobic materials.
Molecular Characterization and Typing of Chicken and Turkey Astroviruses Circulating in the United States: Implications for Diagnostics (2006)

Avian astroviruses were detected by reverse transcriptase and polymerase chain reaction in intestinal contents collected from commercial chickens and turkeys from throughout the United States from 2003 through 2005. Astroviruses were detected in birds from both healthy and poorly performing flocks with or without enteric disease. Phylogenetic analysis was performed with sequence data from the polymerase (ORF-1b) genes of 41 turkey-origin astroviruses and 23 chicken-origin astroviruses. All currently available avian astrovirus sequence data and selected mammalian astrovirus sequence data were included in the analysis. Four groups of avian astroviruses were observed by phylogenetic analysis: turkey astrovirus type 1 (TAstV-1)-like viruses, turkey astrovirus type 2 (TAstV-2)-like viruses, both detected in turkeys; avian nephritis virus (ANV)-like viruses, detected in both chickens and turkeys; and a novel group of chicken-origin astroviruses (CAstV). Among these four groups, amino acid identity was between 50.1% and 73.8%, and was a maximum of 49.4% for all avian isolates when compared with the mammalian astroviruses. There were multiple phylogenetic subgroups within the TAstV-2, ANV, and CAstV groups based on 9% nucleotide sequence divergence. Phylogenetic analysis revealed no clear assortment by geographic region or isolation date. Furthermore, no correlation was observed between the detection of a particular astrovirus and the presence of enteric disease or poor performance. Based on these data, a revision of the present taxonomic classification for avian astroviruses within the genus Avastrovirus is warranted.
An Introduction to Linear Algebra in Parallel Distributed Processing (1987)

This chapter contains sections titled: Vectors, Matrices and Linear Systems, Matrices, Nonlinear Systems
Electrochemical Co-deposition of Sol−Gel/Metal Thin Nanocomposite Films (2008)

A single-step method for the preparation of thin sol−gel/copper mixed films is described, which is based on a novel electrochemical sol−gel methodology, resulting in nanocomposite coating. The method combines electrochemistry with the acceleration of sol−gel hydrolysis and condensation processes. While sol−gel is deposited as a result of increasing the pH in the vicinity of the electrode surface, copper ions are electrochemically reduced. Characterization of the deposited films was accomplished by scanning electron microscopy, X-ray photoelectron spectroscopy, tunneling atomic force microscopy, and other surface techniques. The different parameters that affect the structure and composition of the deposited films have been examined. We found that the morphology and grain size of the films are strongly affected by the ratio between the sol−gel monomer and copper ions. Furthermore, the potential of deposition affects also the composition of the films as it controls the kinetics of sol−gel and copper deposition.
Efficacy of lycopene against fluoride toxicity in rats (2011)

Lycopene administration could minimize the toxic effects of fluoride indicating its free-radical scavenging and powerful anti-oxidant activities.
Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8+ T cells in myeloid malignancies (2010)

These data support the immunogenicity of PR1 and WT1 peptide vaccines. However, repeated delivery of peptides with Montanide-adjuvant and GM-CSF leads to rapid loss of high-avidity peptide-specific CD8(+) T cells. These results may offer an explanation for the lack of correlation between immune and clinical responses observed in a number of clinical trials of peptide vaccination. New approaches are needed to induce long-term high-avidity memory responses against leukemia antigens.
Bridging Multi Agent Systems and Web Services: towards interoperability between Software Agents and Semantic Web Services (2006)

The semantic Web services have been emerging to enable dynamic service discovery, composition, invocation, execution monitoring. On the other hand, software agents are envisioned as autonomous, proactive software entities that act on behalf its users according to a given agenda of goals. Software agents have been envisioned as potential user of semantic Web services in order to interact with semantic descriptions of SWS to autonomously discover, select, compose, invoke and execute the services based on user requirements. However, there exists a communication gap among the both. The major reason is that software agents are not compatible with widely accepted standards of Web services. This paper provides a solution to make multi agent systems compatible with existing Web services standards without changing their existing specifications and implementations, with an assumption that it will be helpful for enabling further interoperability between software agents and semantic Web services. AgentWeb gateway is an initiative for dynamic and seamless interoperation of multi agent systems and Web services. We present abstract architecture and detailed design of the proposed system, abstract algorithms for required protocol transformations, evaluation of the system and analysis of results
Projective convolution (1999)

Article Free Access Share on Projective convolution: RLC model-order reduction using the impulse response Author: Bernard N. Sheehan Mentor Graphics, Wilsonville, OR Mentor Graphics, Wilsonville, ORView Profile Authors Info & Claims DATE '99: Proceedings of the conference on Design, automation and test in EuropeJanuary 1999 Pages 130–eshttps://doi.org/10.1145/307418.307586Published:01 January 1999Publication History 8citation170DownloadsMetricsTotal Citations8Total Downloads170Last 12 Months11Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Overexpressing antioxidant enzymes enhances naphthalene biodegradation in Pseudomonas sp. strain As1 (2007)

We tested the hypothesis that during metabolism of naphthalene and other substrates by Pseudomonas sp. strain As1 oxidative stress arises and can be reduced by antioxidant enzymes. Our approach was to prepare plasmid constructs that conferred expression of two single antioxidant enzymes [Fpr (ferredoxin-NADP(+) reductase) and SOD (superoxide dismutase)] and the pair of enzymes SOD plus AhpC (alkyl hydroperoxide reductase). The fpr, sodA and ahpC genes were placed under the transcriptional control of both the constitutive lac promoter and their respective native promoters. Both HPLC and growth-rate analyses showed that naphthalene metabolism was enhanced in the recombinant strains. All antioxidant-overexpressing recombinant strains, with the exception of one with an upregulated sodA gene due to the lac promoter [strain As1(sodA)], exhibited resistance to the superoxide generating agent paraquat (PQ). The growth of strain As1(sodA) was inhibited by PQ, but this growth defect was rapidly overcome by the simultaneous overproduction of AhpC, which is a known hydrogen peroxide scavenger. After PQ-induced oxidative damage of the [Fe-S] enzyme aconitase, recovery of enzyme activity was enhanced in the recombinant strains. Reporter strains to monitor oxidative stress in strain As1 were prepared by fusing gfp (encoding green fluorescent protein, GFP) to the fpr promoter. Growth on salicylate and naphthalene boosted the GFP fluorescent signal 21- and 14-fold, respectively. Using these same oxidative stress reporters, overexpression of fpr and sodA was found to considerably reduce PQ-induced stress. Taken together, these data demonstrate that the overproduction of Fpr or SodA contributes to oxidative tolerance during naphthalene degradation; however, elevated SOD activity may trigger the generation of excess hydrogen peroxide, resulting in cell death.
Terahertz Wireless Data Transmission With Frequency and Polarization Division Multiplexing Using Resonant-Tunneling-Diode Oscillators (2017)

High-capacity short-distance wireless communications in the terahertz (THz) range are anticipated and therefore have been intensively studied. Higher data rates are made possible by the introduction of frequency division multiplexing (FDM) and polarization division multiplexing (PDM) schemes in the THz range. In this paper, wireless data transmissions using 2-channel FDM in the 500 and 800 GHz ranges and PDM in the 500 GHz range are demonstrated using resonant-tunneling-diode oscillators with different frequencies and polarizations integrated into one chip. Transmissions at a data rate of 28 Gbit/s were achieved in each channel with an error rate below the forward error correction limit in both multiplexing systems. The ratios of the leakage of the transmitted signal in one channel into the other channel were about -40 and -30 dB in FDM and PDM modes, respectively.
Optimizing Human Demineralized Bone Matrix for Clinical Application (2000)

The use of human demineralized bone matrix (DBM) powder in periodontal and orthopedic applications is limited by the variability in the osteoinductive or osteoconductive properties of the material. The goal of the present study was to establish simple in vitro and in vivo assays of DBM that would allow us to screen different lots of the material prior to testing in more rigorous animal models. The results demonstrate a wide variability in the performance of individual lots of DBM powder obtained from a single tissue bank. The studies also demonstrate that relatively simple screening can be used to establish the quality of the different lots, and that performance and ease of handling can be improved by using relatively small particle sizes delivered in a fibrin sealant matrix.
The Energy Harvesting Eel: a small subsurface ocean/river power generator (2001)

The Energy Harvesting Eel (Eel) is a new device that uses piezoelectric polymers to convert the mechanical flow energy, available in oceans and rivers, to electrical power. Eel generators make use of the regular trail of traveling vortices behind a bluff body to strain the piezoelectric elements; the resulting undulating motion resembles that of a natural eel swimming. Internal batteries are used to store the surplus energy generated by the Eel for later use by a small, unattended sensor or robot. Because of the properties of commercially available piezoelectric polymers, Eels will be relatively inexpensive and are easily scaleable in size and have the capacity to generate from milli-watts to many watts depending on system size and flow velocity of the local environment. A practical Eel structure has been developed that uses the commercially available piezoelectric polymer, PVDF. Future Eels may use more efficient electrostrictive polymer. Every aspect of the system from the interactions between the hydrodynamics of the water flow and structural elements of the Eel, through the mechanical energy input to the piezoelectric material, and finally the electric power output delivered through an optimized resonant circuit has been modeled and tested. The complete Eel system, complete with a generation and storage system, has been demonstrated in a wave tank. Future work on the Eel will focus on developing and then deploying a small, lightweight, one-watt power generation unit, initially in an estuary and then subsequently in the ocean. Such Eels will have the ability to recharge batteries or capacitors of a distributed robotic group, or remote sensor array, thus extending the mission life indefinitely in regions containing flowing water.