gebhart/patrepeval huggingface dataset:
Multi-Graph Convolution Collaborative Filtering (2020)

Personalized recommendation is ubiquitous, playing an important role in many online services. Substantial research has been dedicated to learning vector representations of users and items with the goal of predicting a user's preference for an item based on the similarity of the representations. Techniques range from classic matrix factorization to more recent deep learning based methods. However, we argue that existing methods do not make full use of the information that is available from user-item interaction data and the similarities between user pairs and item pairs. In this work, we develop a graph convolution-based recommendation framework, named Multi-Graph Convolution Collaborative Filtering (Multi-GCCF), which explicitly incorporates multiple graphs in the embedding learning process. Multi-GCCF not only expressively models the high-order information via a partite user-item interaction graph, but also integrates the proximal information by building and processing user-user and item-item graphs. Furthermore, we consider the intrinsic difference between user nodes and item nodes when performing graph convolution on the bipartite graph. We conduct extensive experiments on four publicly accessible benchmarks, showing significant improvements relative to several state-of-the-art collaborative filtering and graph neural network-based recommendation models. Further experiments quantitatively verify the effectiveness of each component of our proposed model and demonstrate that the learned embeddings capture the important relationship structure.
Les pompes à insuline (2005)

L'insulinotherapie intensive a considerablement evolue ces dix dernieres annees, notamment dans le domaine de l'administration continue d'insuline. Le point sur les technologies des pompes a insuline.
Use of the tac promoter and lacIq for the controlled expression of Zymomonas mobilis fermentative genes in Escherichia coli and Zymomonas mobilis (1992)

The Zymomonas mobilis genes encoding alcohol dehydrogenase I (adhA), alcohol dehydrogenase II (adhB), and pyruvate decarboxylase (pdc) were overexpressed in Escherichia coli and Z. mobilis by using a broad-host-range vector containing the tac promoter and the lacIq repressor gene. Maximal IPTG (isopropyl-beta-D-thiogalactopyranoside) induction of these plasmid-borne genes in Z. mobilis resulted in a 35-fold increase in alcohol dehydrogenase I activity, a 16.7-fold increase in alcohol dehydrogenase II activity, and a 6.3-fold increase in pyruvate decarboxylase activity. Small changes in the activities of these enzymes did not affect glycolytic flux in cells which are at maximal metabolic activity, indicating that flux under these conditions is controlled at some other point in metabolism. Expression of adhA, adhB, or pdc at high specific activities (above 8 IU/mg of cell protein) resulted in a decrease in glycolytic flux (negative flux control coefficients), which was most pronounced for pyruvate decarboxylase. Growth rate and flux are imperfectly coupled in this organism. Neither a twofold increase in flux nor a 50% decline from maximal flux caused any immediate change in growth rate. Thus, the rates of biosynthesis and growth in this organism are not limited by energy generation in rich medium.
The role of vanin-1 and oxidative stress–related pathways in distinguishing acute and chronic pediatric ITP (2011)

Pediatric immune thrombocytopenia (ITP) is usually self-limited. However, approximately 20% of children develop chronic ITP, which can be associated with significant morbidity because of long-term immunosuppression and splenectomy in refractory cases. To explore the molecular mechanism of chronic ITP compared with acute ITP, we studied 63 pediatric patients with ITP. Gene expression analysis of whole blood revealed distinct signatures for acute and chronic ITP. Oxidative stress-related pathways were among the most significant chronic ITP-associated pathways. Overexpression of VNN1, an oxidative stress sensor in epithelial cells, was most strongly associated with progression to chronic ITP. Studies of normal persons demonstrated VNN1 expression in a variety of blood cells. Exposure of blood mononuclear cells to oxidative stress inducers elicited dramatic up-regulation of VNN1 and down-regulation of PPARγ, indicating a role for VNN1 as a peripheral blood oxidative stress sensor. Assessment of redox state by tandem mass spectrometry demonstrated statistically significant lower glutathione ratios in patients with ITP versus healthy controls; lower glutathione ratios were also seen in untreated patients with ITP compared with recently treated patients. Our work demonstrates distinct patterns of gene expression in acute and chronic ITP and implicates oxidative stress pathways in the pathogenesis of chronic pediatric ITP.
Data delivery in fragmented wireless sensor networks using mobile agents (2007)

Due to the wide range of applications in sensors and Wireless Sensor Networks (WSN), research in this area has recently received increasing attention. WSNs rely on network connectivity to deliver data to a base station through multihop communication. However, connectivity may not be always achievable for a number of reasons. In this paper, we study the problem of data delivery in disconnected WSNs. A special class of disconnected sensor networks called "Fragmented wireless sensor networks (FWSN)" is considered. A FWSN consists of several groups of connected sensors that we call "fragments". To achieve connectivity between these fragments, mobile agents move in the network and act as data relays between fragments, in order to eventually deliver data to the base station. The main contribution of this paper is the modeling of the movement of these mobile relay nodes as a closed queueing network to obtain steady state results of the distribution of the mobile relays in the network. Building on these results, we derive the distributions of the fragment-to-fragment, and fragment-to-sink delays. Comparing these analytical results to results from the TOSSIM simulator, it is shown that this model accurately captures the system behavior, and can be used to predict data delivery delays.
Injection site reactions and antibody responses in sheep and goats after the use of multivalent clostridial vaccines (1987)

Uncertainty concerning the use, efficacy and possible adverse effects of clostridial vaccination in goats prompted a study of the injection site reactions and antibody responses in 40 goats and 40 sheep. The vaccines used were Covexin 8, Heptavac and Tasvax 8. In all the animals swellings averaging 2.5 cm in diameter were present at the injection site seven days after vaccination and were still apparent 28 days after vaccination. The injection site reactions could not be attributed to faulty vaccination technique because they did not occur in a control group injected with sterile water. By 14 days the reactions were significantly larger in sheep than in goats and by 28 days the reactions to Covexin 8 were larger than those to the other vaccines in sheep and goats. Serum antibody was present in all groups before vaccination and, with the exception of the goats vaccinated with Heptavac, increased 14 days after vaccination. The increase was greater in sheep than in goats. By 28 days antibody levels had declined in all but the sheep vaccinated with Heptavac in which a further increase occurred. At that time, the antibody levels in vaccinated sheep were still higher than in the unvaccinated sheep whereas the antibody levels in vaccinated goats were no longer different from those in the control goats. These results suggest that there is a difference between the vaccines used and between the responses of the two species and support the clinical observation that the protection afforded to goats by multivalent clostridial vaccines is poorer than that afforded to sheep.
Reversible Colorimetric Probes for Mercury Sensing (2005)

The selectivity and sensitivity of two colorimetric sensors based on the ruthenium complexes N719 [bis(2,2'-bipyridyl-4,4'-dicarboxylate)ruthenium(II) bis(tetrabutylammonium) bis(thiocyanate)] and N749 [(2,2':6',2' '-terpyridine-4,4',4' '-tricarboxylate)ruthenium(II) tris(tetrabutylammonium) tris(isothiocyanate)] are described. It was found that mercury ions coordinate reversibly to the sulfur atom of the dyes' NCS groups. This interaction induces a color change in the dyes at submicromolar concentrations of mercury. Furthermore, the color change of these dyes is selective for mercury(II) when compared with other ions such as lead(II), cadmium(II), zinc(II), or iron(II). The detection limit for mercury(II) ions--using UV-vis spectroscopy--in homogeneous aqueous solutions is estimated to be approximately 20 ppb for N719 and approximately 150 ppb for N749. Moreover, the sensor molecules can be adsorbed onto high-surface-area mesoporous metal oxide films, allowing reversible heterogeneous sensing of mercury ions in aqueous solution. The results shown herein have important implications in the development of new reversible colorimetric sensors for the fast, easy, and selective detection and monitoring of mercuric ions in aqueous solutions.
Survey on machine learning-based QoE-QoS correlation models (2014)

The machine learning provides a theoretical and methodological framework to quantify the relationship between user OoE (Quality of Experience) and network QoS (Quality of Service). This paper presents an overview of QoE-QoS correlation models based on machine learning techniques. According to the learning type, we propose a categorization of correlation models. For each category, we review the main existing works by citing deployed learning methods and model parameters (QoE measurement, QoS parameters and service type). Moreover, the survey will provide researchers with the latest trends and findings in this field.
A Breakthrough Water Shutoff System for Super-K Zones in Carbonate Ghawwar Field: Adsorption and Polymer System (2016)

Abstract The overall objective of the project is to develop a water shutoff chemical (Sealant), which can be used by Saudi Aramco to control excess water production in carbonate formations. Excessive water production from hydrocarbon-producing wells can adversely affect the economic life of the well. It was estimated that an average 2.8 barrels of water is produced for each barrel of oil worldwide. A new water shutoff polymer system was developed for carbonate formations. The developed system can bond to carbonate and shows great stability. The major challenge of water control in carbonate reservoirs are polymer bonding to the rock surface. Most of the commercial products are designed for sandstone formations. Most polymers will not strongly adsorb to carbonate reservoirs particularly under high fluid flow or high salinity. The polymer system developed is designed to overcome this and chemically bond the polymers to the surface of the carbonate. A well-defined polymer system with the ability to chemically bond to carbonate surfaces were also realized which represents the first example of an adsorption system for carbonate reservoirs and could have broad reaching applications. This represents a significant breakthrough as this can overcome one of the key obstacles of water control in carbonate formations. This paper demonstrates the laboratory work carried out to develop and investigate the efficiency of Smart Sealant, compared with Organically cross linked polymer (OCP), in both Supper-K and fractured rocks. Core flow testes indicate significant drop in water production for both fractured and Supper-K formation. When chemical treatments were applied, the polymer system was able to withstand the differential pressures and did not allow the flow of water in both high permeability cores and fractures. Coreflood results indicate that OCP was unstable with carbonate core sample and leached out after 4 pore volume of brine injection. ESEM and EDS analysis confirmed that the Smart Sealant treatment of the core plug resulted in some of the used polymer product blocking fractures and pores. This finding confirms adsorption and stability of Smart Sealant polymer on the rock surface, blocking fractures and reducing permeability of fractured core samples.
Changing multimode dispersive fibers into single-mode fibers by annealing and guided mode analysis of annealed fibers (1998)

Dispersive fibers whose refractive index differences change greatly with wavelength are fabricated from optical glasses with different index dispersions. The fibers have several guided modes, and are changed into single-mode fibers by annealing under suitable conditions. The number of guided modes is investigated by measuring the bending loss and the mode lines of annealed dispersive fibers. The annealed single-mode fibers support only the fundamental mode over broad spectral ranges and no second guided mode at any wavelength.
Zwitterionic Relatives of Cationic Platinum Group Metal Complexes: Applications in Stoichiometric and Catalytic σ‐Bond Activation (2010)

Zwitterionic platinum group metal complexes that feature formal charge separation between a cationic metal fragment and a negatively charged ancillary ligand combine the desirable reactivity profile of related cationic complexes with the broad solubility and solvent tolerance of neutral species. As such, zwitterionic complexes of this type have emerged as attractive candidates for a diversity of applications, most notably involving the breaking and/or forming of E-H and E-C sigma bonds involving a main group element E. Important advances in ancillary ligand design are documented that have enabled the construction of platinum group metal zwitterions. Also summarized are the results of stoichiometric and catalytic investigations in which the reactivity of such zwitterions and their more traditionally employed cationic relatives in sigma bond activation chemistry are compared and contrasted.
Isolation of pterocarpan synthase, the terminal enzyme of pterocarpan phytoalexin biosynthesis in cell suspension cultures of <i>Cicer arietinum</i> (1988)

Chickpea ( Cicer arietinum L.) cell suspension cultures transferred into a medium containing yeast extract as elicitor accumulate the phytoalexins medicarpin and maackiain. Concomitant with the accumulation of the pterocarpans, a new enzyme activity is induced which catalyses the conversion of the 2′‐hydroxyisoflavanone vestitone to the pterocarpan medicarpin. Maximum enzyme activity was reached 12 h after transfer of cells and then activity declined. The soluble enzyme was partially purified and characterized as pterocarpan synthase.
Intuitive, but not simple: Including explicit water molecules in protein–protein docking simulations improves model quality (2013)

Characterizing the nature of interaction between proteins that have not been experimentally cocrystallized requires a computational docking approach that can successfully predict the spatial conformation adopted in the complex. In this work, the Hydropathic INTeractions (HINT) force field model was used for scoring docked models in a data set of 30 high-resolution crystallographically characterized "dry" protein-protein complexes and was shown to reliably identify native-like models. However, most current protein-protein docking algorithms fail to explicitly account for water molecules involved in bridging interactions that mediate and stabilize the association of the protein partners, so we used HINT to illuminate the physical and chemical properties of bridging waters and account for their energetic stabilizing contributions. The HINT water Relevance metric identified the "truly" bridging waters at the 30 protein-protein interfaces and we utilized them in "solvated" docking by manually inserting them into the input files for the rigid body ZDOCK program. By accounting for these interfacial waters, a statistically significant improvement of ∼24% in the average hit-count within the top-10 predictions the protein-protein dataset was seen, compared to standard "dry" docking. The results also show scoring improvement, with medium and high accuracy models ranking much better than incorrect ones. These improvements can be attributed to the physical presence of water molecules that alter surface properties and better represent native shape and hydropathic complementarity between interacting partners, with concomitantly more accurate native-like structure predictions.
Combined task and motion planning through an extensible planner-independent interface layer (2014)

The need for combined task and motion planning in robotics is well understood. Solutions to this problem have typically relied on special purpose, integrated implementations of task planning and motion planning algorithms. We propose a new approach that uses off-the-shelf task planners and motion planners and makes no assumptions about their implementation. Doing so enables our approach to directly build on, and benefit from, the vast literature and latest advances in task planning and motion planning. It uses a novel representational abstraction and requires only that failures in computing a motion plan for a high-level action be identifiable and expressible in the form of logical predicates at the task level. We evaluate the approach and illustrate its robustness through a number of experiments using a state-of-the-art robotics simulator and a PR2 robot. These experiments show the system accomplishing a diverse set of challenging tasks such as taking advantage of a tray when laying out a table for dinner and picking objects from cluttered environments where other objects need to be re-arranged before the target object can be reached.
Saint Paul et la chair (1982)

Ariès Philippe. Saint Paul et la chair. In: Communications, 35, 1982. Sexualités occidentales. Contribution à l'histoire et à la sociologie de la sexualité, sous la direction de Philippe Ariès et André Béjin. pp. 34-36.
Application of donor/acceptor-carbenoids to the synthesis of natural products (2009)

The metal catalyzed reactions of diazo compounds have been broadly used in organic synthesis. The resulting metal-carbenoid intermediates are capable of undergoing a range of unconventional reactions, and due to their high energy, they are ideal for initiating cascade sequences leading to the rapid generation of structural complexity. This tutorial review will give an overview of the most versatile reactions of donor/acceptor carbenoids, an exciting class of intermediates capable of highly selective reactions. This will include cyclopropanation, [4 + 3] cycloaddition, and C-H functionalization methodologies. The application of this chemistry to the synthesis of a range of natural products will be described.
Stereotactic Helium Ion Bragg Peak Radiosurgery for Intracranial Arteriovenous Malformations (1991)

89 patients with angiographically documented arteriovenous malformations were treated with helium ion Bragg peak radiation. The rate of complete angiographic obliteration 2 years after radiation was 94% in those lesions smaller than 4 cm3 (2.0 cm in diameter), 75% for those 4-25 cm3 and 39% for those larger than 25 cm3 (3.7 cm in diameter); at 3 years after radiation, the corresponding obliteration rates were 100, 95 and 70%. Major clinical complications occurred in 10 patients (8 permanent, 2 transient) between 3 and 21 months after treatment; all were in the initial stage of the protocol (higher radiation doses). 10 patients bled from residual malformation between 4 and 34 months after treatment. Seizures were improved in 63% and headaches in 68% of patients. Excellent or good clinical outcome was achieved in 94% of patients. Compared to the natural history and risks of surgery for these difficult malformations, we consider these results encouraging. Heavy-charged-particle radiation is a valuable therapy for surgically inaccessible symptomatic cerebral arteriovenous malformations. The current procedure has two disadvantages: the prolonged latent period before complete obliteration and the small risk of serious neurological complications.
Constricted Flux through the Branched-Chain Amino Acid Biosynthetic Enzyme Acetolactate Synthase Triggers Elevated Expression of Genes Regulated by <i>rpoS</i> and Internal Acidification (1998)

The first common enzyme of isoleucine and valine biosynthesis, acetolactate synthase (ALS), is specifically inhibited by the herbicide sulfometuron methyl (SM). To further understand the physiological consequences of flux alterations at this point in metabolism, Escherichia coli genes whose expression was induced by partial inhibition of ALS were sought. Plasmid-based fusions of random E. coli DNA fragments to Photorhabdus luminescens luxCDABE were screened for bioluminescent increases in actively growing liquid cultures slowed 25% by the addition of SM. From more than 8,000 transformants, 12 unique SM-inducible promoter-lux fusions were identified. The lux reporter genes were joined to seven uncharacterized open reading frames, f253a, f415, frvX, o513, o521, yciG, and yohF, and five known genes, inaA, IdcC, osmY, poxB, and sohA. Inactivation of the rpoS-encoded sigma factor, sigmaS, reduced basal expression levels of six of these fusions 10- to 200-fold. These six genes defined four new members of the sigmaS regulon, f253a, IdcC, yciG, and yohF, and included two known members, osmY and poxB. Furthermore, the weak acid salicylate, which causes cytoplasmic acidification, also induced increased bioluminescence from seven SM-inducible promoter-lux fusion-containing strains, namely, those with fusions of the sigmaS-controlled genes and inaA. The pattern of gene expression changes suggested that restricted ALS activity may result in intracellular acidification and induction of the sigmaS-dependent stress response.
Application of Surface Reconstruction for Car Undercarriage Inspection (2020)

The method for camera-based 3D reconstruction of car undercarriages is proposed in this paper. It is designed for a special scanner, which is placed under a road level and scans undercarriages of passing cars. The scanner uses mirrors to increase a distance from a camera and to capture a stereo image only by one camera. The 3D models of individual parts of an undercarriage are reconstructed by a correlation-based block-matching algorithm. Afterward, these models are stitched together based-on visual odometry. The method was successfully tested on real car undercarriages.
Highly Thermally Resistant and Flexible Polyimide Aerogels Containing Rigid-rod Biphenyl, Benzimidazole, and Triphenylpyridine Moieties: Synthesis and Characterization (2013)

Abstract Polyimide (PI) aerogels containing rigid-rod biphenyl, benzimidazole, and triphenylpyridine moieties have been developed. The flexible PI aerogels exhibited excellent thermal stability with glass-transition temperatures (Tg) higher than 350 °C. Initial porous structures in the PI aerogels could be maintained even after isothermal aging at 300 °C for 24 h in nitrogen. Furthermore, the weight losses of the aerogels after isothermal aging at 300 and 400 °C for 24 h in nitrogen were below 5 and 10 wt %, respectively.
C-Reactive Protein, Fatal and Nonfatal Coronary Artery Disease, Stroke, and Peripheral Artery Disease in the Prospective EPIC-Norfolk Cohort Study (2013)

In the EPIC-Norfolk cohort, CRP was associated with fatal and nonfatal CAD events, as well as nonfatal PAD events. Adding CRP to risk stratification models resulted in a small improvement in classification for both fatal and nonfatal events. Importantly, CRP was significantly more strongly associated with fatal CAD events than with nonfatal CAD events.