gebhart/patrepeval huggingface dataset:
Micro-Sector Cache (2017)

Recent research proposals on DRAM caches with conventional allocation units (64 or 128 bytes) as well as large allocation units (512 bytes to 4KB) have explored ways to minimize the space/latency impact of the tag store and maximize the effective utilization of the bandwidth. In this article, we study sectored DRAM caches that exercise large allocation units called sectors, invest reasonably small storage to maintain tag/state, enable space- and bandwidth-efficient tag/state caching due to low tag working set size and large data coverage per tag element, and minimize main memory bandwidth wastage by fetching only the useful portions of an allocated sector. However, the sectored caches suffer from poor space utilization, since a large sector is always allocated even if the sector utilization is low. The recently proposed Unison cache addresses only a special case of this problem by not allocating the sectors that have only one active block. We propose Micro-sector cache, a locality-aware sectored DRAM cache architecture that features a flexible mechanism to allocate cache blocks within a sector and a locality-aware sector replacement algorithm. Simulation studies on a set of 30 16-way multi-programmed workloads show that our proposal, when incorporated in an optimized Unison cache baseline, improves performance (weighted speedup) by 8%, 14%, and 16% on average, respectively, for 1KB, 2KB, and 4KB sectors at 128MB capacity. These performance improvements result from significantly better cache space utilization, leading to 18%, 21%, and 22% average reduction in DRAM cache read misses, respectively, for 1KB, 2KB, and 4KB sectors at 128MB capacity. We evaluate our proposal for DRAM cache capacities ranging from 128MB to 1GB.
Location-specific growth and transfer of arrayed MoS <sub>2</sub> monolayers with controllable size (2017)

We present a controlled chemical vapor deposition (CVD) growth and transfer of arrayed MoS2 monolayers on predetermined locations. The patterned transition metal oxide (e.g. MoO3) source substrate was contacted face-to-face with an SiO2 growth substrate, where localized MoS2 flakes were synthesized on both source and growth substrates, following a CVD procedure. This growth technique enabled the growth of both single crystalline and polycrystalline MoS2 monolayer arrays with controlled size and location, exclusively on predetermined locations on the growth substrates. As-grown MoS2 arrays were transferred using a unique process that combines the wet and stamping transfer processes and dramatically enhanced the integrity of transferred MoS2 on microstructures, while protecting the microstructures during the transfer process. This fabrication technique can be applied to different transition metal dichalcogenides (TMDs) and allows the formation of TMDs on select locations, potentially eliminating a post-lithography step for device fabrication.
Long‐lasting Anticonvulsant Effect of Focal Cooling on Experimental Neocortical Seizures (2003)

These experiments show that gentle cooling to 20 degrees C is capable of markedly reducing subsequent seizure frequency and intensity. The effects in our model, which generates very frequent and intense ictal activity, were robust, suggesting that prophylactic cooling might be even more beneficial in clinical situations. The physiologic mechanism for this preventive effect requires elucidation.
Generalized Scatter Plots (2009)

Scatter Plots are one of the most powerful and most widely used techniques for visual data exploration. A well-known problem is that scatter plots often have a high degree of overlap, which may occlude a significant portion of the data values shown. In this paper, we propose the generalized scatter plot technique, which allows an overlap-free representation of large data sets to fit entirely into the display. The basic idea is to allow the analyst to optimize the degree of overlap and distortion to generate the best-possible view. To allow an effective usage, we provide the capability to zoom smoothly between the traditional and our generalized scatter plots. We identify an optimization function that takes overlap and distortion of the visualization into acccount. We evaluate the generalized scatter plots according to this optimization function, and show that there usually exists an optimal compromise between overlap and distortion. Our generalized scatter plots have been applied successfully to a number of real-world IT services applications, such as server performance monitoring, telephone service usage analysis and financial data, demonstrating the benefits of the generalized scatter plots over traditional ones.
Production of ethanol from -arabinose by containing a fungal -arabinose pathway (2003)

The fungal pathway for L-arabinose catabolism converts L-arabinose to D-xylulose 5-phosphate in five steps. The intermediates are, in this order: L-arabinitol, L-xylulose, xylitol and D-xylulose. Only some of the genes for the corresponding enzymes were known. We have recently identified the two missing genes for L-arabinitol 4-dehydrogenase and L-xylulose reductase and shown that overexpression of all the genes of the pathway in Saccharomyces cerevisiae enables growth on L-arabinose. Under anaerobic conditions ethanol is produced from L-arabinose, but at a very low rate. The reasons for the low rate of L-arabinose fermentation are discussed.
A dinucleotide deletion in exon 4 of the PlA2 allelic form of glycoprotein IIIa: implications for the correlation of serologic versus genotypic analysis of human platelet alloantigens (1996)

Platelets from a patient with a suspected case of posttransfusion purpura were subjected to alloantigen phenotyping and found to express the PlA1, but not the PlA2, allelic form of human platelet membrane glycoprotein (GP) IIIa on the platelet surface. However, genotyping showed unambiguously that the patient carried the genes for both of these GPIIa alleles. Based on these results, we postulated that the PlA2 allele was silent, ie, that this patient was a carrier for Glanzmann thrombasthenia (GT). Quantitative analysis of GPIIb-IIIa surface expression showed only 20,000 GPIIb-IIIa receptors/platelet, approximately half of the value obtained with control platelets. Southern blot analysis showed no large deletions or insertions within the GPIIIa gene, and amplification of all 14 exons encoding GPIIIa resulted in the production of normal sized polymerase chain reaction (PCR) products in all cases. DNA-sequence analysis showed an AG dinucleotide deletion affecting codons 210 and 211 within exon 4 of the GPIIIa gene, leading to a change in reading frame and the creation of a stop codon 38 nucleotides down-stream. The predicted truncated protein consists of only the first 223 of the normal 762 amino acids, thus accounting for the failure to express the PlA2 allele on the platelet surface. While encountered only rarely, carriers of either GT or Bernard Soulier syndrome that are at the same time heterozygous for human platelet alloantigenic epitopes found on GPIb, GPIIb, or GPIIIa have the possibility to give discrepant results when comparing genotypic versus phenotypic analysis. In such situations, the combination of serologic and DNA-based evaluation contributes complementary and beneficial diagnostic information than either one alone are able to provide.
Continuous-wave mode-locked visible upconversion laser (1992)

We describe continuous-wave mode locking and Q switching of an Er:LiYF(4) trio upconversion laser operating in the green spectral region.
On the Structures of Crambescins B and C1 (1993)

Revised structures have been assigned to the cyclic guanidine-containing crambescins B [3] and C1 [5], from the Mediterranean sponge Crambe crambe. The revisions were based on the fabms/cid/ms spectra of the [M+H]+ ions from crambescins B and C1 and hrfabms measurements on key fragment ions in the ms/ms spectra, which identify losses of C9H19 and C8H18N3O side-chains.
Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors (2017)

Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system. In this study, 5-hydroxy pyridine derivatives were designed, synthesized, and evaluated for their in vitro biological activities by two-electrode voltage clamp assay at hP2X3 receptors. Among the novel hP2X3 receptor antagonists, intrathecal treatment of compound 29 showed parallel efficacy with pregabalin (calcium channel modulator) and higher efficacy than AF353 (P2X3 receptor antagonist) in the evaluation of its antiallodynic effects in spinal nerve ligation rats. However, because compound 29 was inactive by intraperitoneal administration in neuropathic pain animal models due to low cell permeability, the corresponding methyl ester analogue, 28, which could be converted to compound 29 in vivo, was investigated as a prodrug concept. Intravenous injection of compound 28 resulted in potent antiallodynic effects, with ED<sub>50</sub> values of 2.62 and 2.93 mg/kg in spinal nerve ligation and chemotherapy-induced peripheral neuropathy rats, respectively, indicating that new drug development targeting the P2X3 receptor could be promising for neuropathic pain, a disease with high unmet medical needs.
Label-Free Telomerase Activity Detection via Electrochemical Impedance Spectroscopy (2019)

In the last decade, researchers have been searching for innovative platforms, methods, and techniques able to address recurring problems with the current cancer detection methods. Early disease detection, fast results, point-of-care sensing, and cost are among the most prevalent issues that need further exploration in this field. Herein, studies are focused on overcoming these problems by developing an electrochemical device able to detect telomerase as a cancer biomarker. Electrochemical platforms and techniques are more appealing for cancer detection, offering lower costs than the established cancer detection methods, high sensitivity inherent to the technique, rapid signal processing, and their capacity of being miniaturized. Therefore, Au interdigital electrodes and electrochemical impedance spectroscopy were used to detect telomerase activity in acute T cell leukemia. Different cancer cell concentrations were evaluated, and a detection limit of 1.9 × 10<sup>5</sup> cells/mL was obtained. X-ray photoelectron spectroscopy was used to characterize the telomerase substrate (TS) DNA probe self-assembled monolayer on gold electrode surfaces. Atomic force microscopy displayed three-dimensional images of the surface to establish a height difference of 9.0 nm between the bare electrode and TS-modified Au electrodes. The TS probe is rich in guanines, thus forming secondary structures known as G-quadruplex that can be triggered with a fluorescence probe. Confocal microscopy fluorescence images showed the formation of DNA G-quadruplex because of TS elongation by telomerase on the Au electrode surface. Moreover, electrodes exposed to telomerase containing 2',3'-dideoxyguanosine-5'-triphosphate (ddGTP) did not exhibit high fluorescence, as ddGTP is a telomerase inhibitor, thus making this device suitable for telomerase inhibitors capacity studies. The electrochemical method and Au microchip device may be developed as a biosensor for a point-of-care medical device.
Gray-tone lithography using an optical diffuser and a contact aligner (2008)

This paper describes a simple method for the three-dimensional (3D) microfabrication of complex high-aspect structures in a one mask lithography process. The method relies on an unconventional way of performing gray-tone lithography. The main idea is to randomize the collimated light by using an optical diffuser to generate intensity distributions in the photoresist. The resist topography is determined by the density of open and opaque squares in the photomask. The resulting 3D resist is then transferred into 3D silicon structures by using reactive ion etching and deep reactive ion etching.
Comparative Analysis of Robotics-Assisted and Manual Insertions of Cochlear Implant Electrode Arrays (2022)

Robotics-assisted insertion systems enable standardized electrode insertions across individual surgeons and experience levels. Clinical trials are necessary to investigate whether insertion techniques that reduce insertional variability and the likelihood of intracochlear trauma also improve CI auditory outcomes.
Ionic Winds for Enhanced Cooling in Portable Platforms (2008)

While cooling of the microchip continues to receive significant interest in most electronic devices, portable platforms such as notebooks, multi-use cellular phones, and ultra-mobile personal computers (PCs) present unique thermal management challenges as well. Cooling non-processor components such as wireless devices and the skin of the device are becoming the important thermal management drivers, and volume and power constraints are limiting the practicality of including larger or additional conventional fans. Ionic wind engines are devices which generate air flow with no moving parts, and feature low power consumption and a small volumetric footprint. An ionic wind is produced when positive air ions are accelerated in a particular direction by an electric field, and exchange momentum with neutral air molecules, thus generating a body force on the air. In the presence of an existing bulk flow, an ionic wind distorts the boundary layer and increases the local cooling effect at a heated wall. A free-standing ionic wind engine with an electrode gap of approximately 1 mm has been constructed. Experiments show that the ionic wind engine can enhance the local heat transfer coefficient of a low-speed flow by as much as 50%. The impact of the ionic wind is shown to increase with current and decrease as the bulk flow increases.
Bandpass sigma-delta modulation using frequency translation (2002)

A bandpass sigma-delta modulation Analog-to-Digital (A/D) converter that uses direct conversion to base-band with in phase and quadrature paths within the feedback loop is described. The bandpass input signal is processed with continuous-time circuitry and the I/Q base-band signals are processed with switched-capacitor circuits. Experimental and simulation results indicate that the passband center frequency can be maximized while suppressing the effects of I/Q mismatches.
A blood based 12-miRNA signature of Alzheimer disease patients (2013)

The data indicate that deregulated miRNAs in blood might be used as biomarkers in the diagnosis of AD or other neurological diseases.
Selective ablation of atheromas using a flashlamp-excited dye laser at 465 nm. (1986)

Ablation of human atheromas with laser pulses that had only a small effect on normal artery tissue was shown in vitro in air and under saline using 1-mu sec pulses at 465 nm from a flashlamp-excited dye laser. At this wavelength, there is preferential absorption in atheromas due to carotenoids. The threshold fluence for ablation was 6.8 +/- 2.0 J/cm2 for atheromas and 15.9 +/- 2.2 J/cm2 for normal aorta tissue. At a fluence of 18 J/cm2 per pulse, the ablated mass per unit of energy ranged from 161 to 370 micrograms/J for atheromas and from 50 to 74 micrograms/J for normal aorta tissue. Ablation products consisted of cholesterol crystals, shredded collagen fibers, and small bits of calcific material. Most debris was less than 100 micron in diameter, but a few pieces were as large as 300 micron. High-speed photography of ablation in air suggested explosive ejection of debris, caused by vapor formation, at speeds on the scale of 300 m/sec. Histological analysis showed minimal thermal damage to residual tissue. These data indicate that selective laser ablation of atheromas is possible in vitro.
Integration of Attributes from Non-Linear Characterization of Cardiovascular Time-Series for Prediction of Defibrillation Outcomes (2016)

At clinically relevant sensitivity thresholds, the MDI provides improved performance as compared to AMSA, yielding fewer unsuccessful defibrillations. Addition of partial end-tidal carbon dioxide (PetCO2) signal improves accuracy and sensitivity of the MDI prediction model.
A novel synthetic CDC25 phosphatase inhibitor inhibits human cancer growth in vitro and in vivo (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

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CDC25 phosphatases (CDC25A, B and C) play a critical role by dephosphorylating and activating cyclin-dependent kinases (CDKs) thus leading to the phosphorylation of key substrates for cell cycle progression and mitosis. Increase of expression of the members of CDC25 family have been reported in several human cancers compared to normal tissues suggesting an active role in tumorigenesis.

Here, we report the in vitro and in vivo characterization of a novel synthetic CDC25 inhibitor. This inhibitor is active against several purified human CDC25 family members (A, B2, B3, & C) in the nanomolar range. Short exposure of this compound at low concentrations are sufficient to inhibit the proliferation of a large panel of human tumor cell lines including drug resistant cell lines. Its antiproliferative activity is observed with tumor cells growing as monolayer, as well as in colony in clonogenicity assay or as spheroids in 3 dimensions. Finally, this inhibitor reduces the growth rate of human tumors xenografted in athymic mice.

Together, these results strongly support further interest in pursuing investigation of CDC25 inhibitors against human cancers.
Metaphase Cytogenetics Adds to Gene Expression Profiling in the Identification of High Risk Multiple Myeloma. (2006)

Abstract The International Staging System (ISS), based on B2-microglobulin and albumin levels at the time of diagnosis, has now generally been adopted as a new prognostic classification system for multiple myeloma (MM). While readily and widely applicable, ISS does not account for genetic disease features, such as metaphase (CA) and interphase fluorescence in situ hybridization (FISH) cytogenetic abnormalities, which when examined in the context of standard prognostic variables, confer higher hazards of relapse and disease-related death. Recently, gene expression profiling (GEP) uncovered the major prognostic significance for outcome of high expression of CKS1B, a gene mapping to an amplicon at chromosome 1q21. We have performed a comprehensive study of CA, FISH, GEP and ISS staging in 351 newly diagnosed MM patients, treated uniformly on Total Therapy 2. We have analyzed outcome based on a combination of high CKS1B by GEP and CA. GEP-based t(11;14) was prognostically favorable, irrespective of expression of CKS1B and, therefore, was removed from the group of patients with high CKS1B expression. After this adjustment, with the combination of both CA and high CKS1B (approximately 10% of all patients) conferred a very poor outcome with only 24% and 40% of such patients being event-free and/surviving at 3 years, compared with 72% and 84% for the others (p values : &lt;.0001). Such patients fared poorly, irrespective of their ISS stage. Similar prognostic information could be gained by combining CA with FISH-defined amplification of 1q21 and t(11;14). Because of their major prognostic impact, all newly diagnosed patients should be tested for these genetic markers. Novel treatment modalities are justified in the small subgroup of such poor prognosis patients, since they derive only a minor benefit from advances in MM therapy. CKS1B Q4 + CA (with no CCND1) vs. Others CKS1B Q4 + CA (with no CCND1) vs. Others
Signal detection for page-access optical memories with intersymbol interference (1996)

We propose a technique for data detection in a two-dimensional page-access optical memory. The technique combines sequence detection by the use of the Viterbi algorithm with decision feedback to improve the bit-error-rate performance in a system corrupted by intersymbol interference. It has an advantage in that it can be operated on a row-by-row basis as data are output from the optical detector. Use of the proposed scheme might ease the design tolerances of the optical components or permit the use of large data pages.
Tumorigenicity of the <i>met</i> Proto-Oncogene and the Gene for Hepatocyte Growth Factor (1992)

The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF). It was previously shown that, like the oncogenic tpr-met, the mouse met proto-oncogene transforms NIH 3T3 cells. We have established NIH 3T3 cells stably expressing both human (Methu) and mouse (Metmu) met proto-oncogene products. The protein products are properly processed and appear on the cell surface. NIH 3T3 cells express endogenous mouse HGF/SF mRNA, suggesting an autocrine activation mechanism for transformation by Metmu. However, the tumor-forming activity of Methu in NIH 3T3 cells is very low compared with that of Metmu, but efficient tumorigenesis occurs when Methu and HGF/SFhu are coexpressed. These results are consistent with an autocrine transformation mechanism and suggest further that the endogenous murine factor inefficiently activates the tumorigenic potential of Methu. The tumorigenicity observed with reciprocal chimeric human and mouse receptors that exchange external ligand-binding domains supports this conclusion. We also show that HGF/SFhu expressed in NIH 3T3 cells produces tumors in nude mice.
Statistical analysis of a signal separation method based on second order statistics (2002)

This paper explores an existing method for signal separation, which is based on second order statistics. Here, statistical analysis of a generalized version of the original algorithm is given. The generalized method includes a weighting matrix, and a result of the statistical analysis is that the best possible weighting is found. The problem of initialization of the involved non-linear optimization is also discussed.
Control Considerations for an On-Line, Active Regeneration System for Diesel Particulate Traps (1989)

Garrett Automotive Group is developing an exhaust aftertreatment system aimed at particulate emissions reduction from commercial diesel engines. The system uses a ceramic wall flow filter to trap the particulates, and regeneration is effected by raising gas temperature by throttling the exhaust downstream of the turbocharger. Lab testing at steady conditions demonstrated good performance with both catalyzed and uncatalyzed traps. Road testing shows the regeneration must be accomplished under severe transient conditions created by the normal vehicle operating modes. Primary efforts are to accommodate those transients using advanced control and digital computational techniques. Some of those techniques are described and are shown to yield improved control performance.
Small scale windmill (2007)

In this letter the authors report experimental results on an optimized small scale piezoelectric windmill, which can solve the problems associated with autonomous sensor networks in outdoor, remote or inaccessible locations. The whole structure of the windmill is made of plastic, and it utilizes 18 piezoelectric bimorphs which makes this design extremely cost effective. The windmill was tested at average wind speed of 10miles∕h and it provided 5mW continuous power. The threshold wind speed for the windmill was found to be of the order of 5.4miles∕h. Further, the authors present analysis on two other windmill structures which illustrate the design parameters required for small scale windmill.