gebhart/patrepeval huggingface dataset:
Rhein, a Natural Anthraquinone Derivative, Attenuates the Activation of Pancreatic Stellate Cells and Ameliorates Pancreatic Fibrosis in Mice with Experimental Chronic Pancreatitis (2013)

Pancreatic fibrosis, a prominent histopathological feature of chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma, is essentially a dynamic process that leads to irreversible scarring of parenchymal tissues of the pancreas. Though the exact mechanisms of its initiation and development are poorly understood, recent studies suggested that the activation of pancreatic stellate cells (PSCs) plays a critical role in eliciting such active course of fibrogenesis. Anthraquinone compounds possess anti-inflammatory bioactivities whereas its natural derivative rhein has been shown to effectively reduce tissue edema and free-radical production in rat models of inflammatory conditions. Apart from its anti-inflammatory properties, rhein actually exerts strong anti-fibrotic effects in our current in-vivo and in-vitro experiments. In the mouse model of cerulein-induced CP, prolonged administration of rhein at 50 mg/kg/day significantly decreased immunoreactivities of the principal fibrotic activators alpha-smooth muscle actin (α-SMA) and transforming growth factor-beta (TGF-β) on pancreatic sections implicating the activation of PSCs, which is the central tread to fibrogenesis, was attenuated. Consequently, the overwhelmed deposition of extracellular matrix proteins fibronectin 1 (FN1) and type I collagen (COL I-α1) in exocrine parenchyma was found accordingly reduced. In addition, the expression levels of sonic hedgehog (SHH), which plays important roles in molecular modulation of various fibrotic processes, and its immediate effector GLI1 in pancreatic tissues were positively correlated to the degree of cerulein-induced fibrosis. Such up-regulation of SHH signaling was restrained in rhein-treated CP mice. In cultured PSCs, we demonstrated that the expression levels of TGF-β-stimulated fibrogenic markers including α-SMA, FN1 and COL I-α1 as well as SHH were all notably suppressed by the application of rhein at 10 μM. The present study firstly reported that rhein attenuates PSC activation and suppresses SHH/GLI1 signaling in pancreatic fibrosis. With strong anti-fibrotic effects provided, rhein can be a potential remedy for fibrotic and/or PSC-related pathologies in the pancreas.
Ferroelectric liquid-crystal tunable filter (1989)

A new discrete-channel tunable Lyot filter that uses ferroelectric liquid-crystal (FLC) smectic C* wave plates is described and demonstrated. The device is tuned by changing the retardation of each birefringent element. This is achieved by electrically rotating the FLC wave plates in each stage by 45 degrees , which effectively changes the design wavelength of the Lyot filter. The transmission characteristics of such a device are demonstrated in a three-stage filter and show good agreement with theory. Advantages of the FLC tunable filter over existing filter structures include low switching voltages (+/-10 V), rapid tunability (~100 kHz), potentially high transmission and wide field of view, and large entrance aperture.
Bonding of InP laser diodes by Au-Sn solder and tungsten-based barrier metallization schemes (1994)

Ti/W/Au-Sn and Ti/WxMy/Au-Sn schemes were studied as alternative metallization schemes to the traditionally used Ti/Pt/Au-Sn system for the bonding of InP laser diodes to heatsinks, and in particular to CVD diamond parts. The study comprised the Ti/W, Ti/W1(Au-Sn) and Ti/W1(Ni-Sn) barrier metal schemes, co-deposited in between the Au-Sn solder and the submount. In particular, reactivity and thermodynamic stability of the systems, acid the integrity of the barrier metal to the AuSn solder interface through the thermal bonding refreezing and reflow cycles were tracked. Premature freezing of the solder through the bonding cycles was attributed to the intermixing of the underlying barrier metal and the solder, suggesting an insufficient thermodynamic stability. Dewetting of the solder from the barrier metals through the reflowing cycle, subsequent to the completion of the bonding cycle, occurs due to the excellent inert nature of the solder to the barrier system, but exhibited the deficiency of poor solder to barrier metal adhesion. The TIM, system performed as an absolute inert barrier under the Au-Sn solder, in which no premature freezing phenomena were observed through the bonding cycle, resulting, however, in a delamination of the solder from the Ti/W, while reflown both under flux and forming-gas. In order to maintain the stable nature of this system, but to improve the barrier-solder interfacial integrity, W-Au, W-AuSn and W-NiSn co-deposited intermediate adhesion layers were introduced in between the W layer and the Au-Sn solder. As a result, the adhesion of the solder to the barrier metal improved, while the most stable performance was observed while applying the W/W(NiSn) barrier system under the Au-Sn solder. The first local freezing phenomenon of the bonding solder, while using this system, was observed only after heating the sample to 320 degrees C for more than 3 min and more than 1 h was needed to completely freeze the entire solder. in addition, an excellent solder to metal interfacial integrity was observed through the gas and flux reflow cycle. Thus, the W/W(NiSn) barrier metallization is recommended as a superior scheme to replace the traditionally used Ti/Pi system for bonding laser diodes to any type of submount using Au-Sn solder.
Device for measuring vibrations on rotating blade (1993)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Hideyasu Iinuma, Takashi Wakatsuki, Nobuya Minagawa; Device for measuring vibrations on rotating blade. J. Acoust. Soc. Am. 1 December 1993; 94 (6): 3534. https://doi.org/10.1121/1.407160 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Fluorescent HPLC assay for 20-HETE and other<i>P</i>-450 metabolites of arachidonic acid (2000)

This study describes a fluorescent HPLC assay for measuring 20-hydroxyeicosatetraenoic acid (20-HETE) and other cytochrome P-450 metabolites of arachidonic acid in urine, tissue, and interstitial fluid. An internal standard, 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid, was added to samples, and the lipids were extracted and labeled with 2-(2,3-naphthalimino)ethyl trifluoromethanesulfonate. P-450 metabolites were separated on a C18 reverse-phase HPLC column. Coelution and gas chromatography-mass spectrometry studies confirmed the identity of the 20-HETE peak. The 20-HETE peak can be separated from those for dihydroxyeicosatrienoic acids, other HETEs, and epoxyeicosatrienoic acids. Known amounts of 20-HETE were used to generate a standard curve (range 1-10 ng, r(2) = 0.98). Recovery of 20-HETE from urine averaged 95%, and the intra-assay variation was <5%. Levels of 20-HETE were measured in 100 microliter of urine and renal interstitial fluid or 0.1 mg of renal tissue. The assay was evaluated by studying the effects of 1-aminobenzotriazole (ABT) on the excretion of 20-HETE in rats. ABT reduced excretion of 20-HETE by >65% and inhibited the formation of 20-HETE by renal microsomes. The availability of this assay should facilitate work in this field.
High bond reliability of newly developed silver alloy bonding wire (2019)

Abstract In this paper, a new type of silver (Ag) alloy bonding wire is introduced, and its bonding property and long term reliability are demonstrated. The new Ag wire, called GX2s, is developed as a cost-effective alternative to gold (Au) wire targeting at automotive electronics. The wire material is doped with added element, and its electrical resistivity is much lower than the conventional palladium (Pd) doped Ag wire. Highly accelerated stress test (HAST) and high temperature storage life (HTSL) test were carried out along with other bonding evaluations. The results show that GX2s has good bonding property and excellent long term bond reliability. Microstructural analyses of bond interface after the reliability tests were also conducted to investigate its improving mechanism. GX2s is a suitable alternative to Au wire for many applications including high temperature automotive devices.
Reproducibility of SD-OCT–Based Ganglion Cell–Layer Thickness in Glaucoma Using Two Different Segmentation Algorithms (2013)

SD-OCT-based GCL+IPL thickness measurements in patients with early glaucoma are highly reproducible.
Parameterization and Observability Analysis of Scalable Battery Clusters for Onboard Thermal Management (2013)

Although the battery surface temperature is commonly measured, the core temperature of a cell may be much higher hence more critical than the surface temperature. The core temperature of a battery, though usually unmeasured in commercial applications, can be estimated by an observer, based on a lumped-parameter battery thermal model and the measurement of the current and the surface temperature. Even with a closed loop observer based on the measured surface temperature, the accuracy of the core temperature estimation depends on the model parameters. For such purpose, an online parameterization methodology and an adaptive observer are designed for a cylindrical battery. The single cell thermal model is then scaled up to create a battery cluster model to investigate the temperature pattern of the cluster. The modeled thermal interconnections between cells include cell to cell heat conduction and convection to the surrounding coolant flow. An observability analysis is performed on the cluster before designing a closed loop observer for the pack. Based on the analysis, guidelines for determining the minimum number of required sensors and their exact locations are derived that guarantee the observability of all temperature states.
Novel Derivatives of Phenethyl-5-Bromopyridylthiourea and Dihydroalkoxybenzyloxopyrimidine Are Dual-Function Spermicides with Potent Anti-Human Immunodeficiency Virus Activity (1999)

Sexually active women represent the fastest growing HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome) risk group. In an effort to develop a vaginal microbicidal contraceptive potentially capable of preventing HIV transmission as well as providing fertility control, we have synthesized novel non-nucleoside inhibitors (NNIs) of HIV-1 reverse transcriptase (RT) and examined them for dual-function anti-HIV and spermicidal activity. Structure-based drug design by use of a computer docking procedure for the NNI binding pocket generated from nine RT-NNI crystal structures led to the synthesis of three novel NNIs: N-[2-(2, 5-dimethoxyphenethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (D-PBT); N-[2-(2-fluorophenethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (F-PBT); and 5-isopropyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-on e (S-DABO). The anti-HIV activity of these NNIs was compared with that of trovirdine and virucidal/spermicide, nonoxynol-9 (N-9), by measuring viral RT activity and p24 antigen production as markers of viral replication using HTLVIIIB-infected human peripheral blood mononuclear cells (PBMCs). The effects on sperm motion kinematics and sperm membrane integrity were examined by computer-assisted sperm analysis and by confocal laser scanning microscopy (CLSM), respectively. The growth-inhibitory effects of NNI versus N-9 against normal human ectocervical and endocervical epithelial cells were tested using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. All three NNIs were potent inhibitors of purified recombinant HIV RT and abrogated HIV replication in PBMCs at nanomolar concentrations (IC50 < 1 nM) when compared with N-9 or trovirdine (IC50 values of 2.2 microM and 0.007 microM, respectively). Two NNIs, F-PBT and S-DABO, also exhibited concentration- and time-dependent spermicidal activity. The drug concentration required to inhibit sperm motility by 50% (EC50 values) for the lead compound F-PBT versus N-9 was 147 microM and 81 microM, respectively. Sperm-immobilizing activity induced by F-PBT and S-DABO was rapid (t1/2 = 7-13 min) and irreversible. Unlike that of N-9, spermicidal activity of F-PBT and S-DABO was not accompanied by loss of acrosomal membrane as detected by fluorescent-lectin binding assay and CLSM. Whereas N-9 was cytotoxic to normal human ectocervical and endocervical cells at spermicidal doses, both F-PBT and S-DABO were selectively spermicidal. We conclude that as potent anti-HIV agents with spermicidal activity and reduced cytotoxicity, F-PBT and S-DABO show unique clinical potential to become the active ingredients of a vaginal contraceptive for women who are at high risk for acquiring HIV by heterosexual vaginal transmission.
Diamond-Coated Carbon Nanotubes for Efficient Field Emission (2005)

Field-emission cathodes containing arrays of carbon nanotubes coated with diamond or diamondlike carbon (DLC) are undergoing development. Multiwalled carbon nanotubes have been shown to perform well as electron field emitters. The idea underlying the present development is that by coating carbon nanotubes with wideband- gap materials like diamond or DLC, one could reduce effective work functions, thereby reducing threshold electric-field levels for field emission of electrons and, hence, improving cathode performance. To demonstrate feasibility, experimental cathodes were fabricated by (1) covering metal bases with carbon nanotubes bound to the bases by an electrically conductive binder and (2) coating the nanotubes, variously, with diamond or DLC by plasma-assisted chemical vapor deposition. In tests, the threshold electric-field levels for emission of electrons were reduced by as much as 40 percent, relative to those of uncoated- nanotube cathodes. Coating with diamond or DLC could also make field emission-cathodes operate more stably by helping to prevent evaporation of carbon from nanotubes in the event of overheating of the cathodes. Cathodes of this type are expected to be useful principally as electron sources for cathode-ray tubes and flat-panel displays.
Estimating the Delay and Coloration Effect of the Acoustic Echo Path for Low Complexity Echo Suppression (2005)

Acoustic echoes arise whenever there is acoustic coupling between a loudspeaker and a microphone. A traditional solution for eliminating the undesired echo signal is an acoustic echo canceler (AEC), which identifies the echo path between a loudspeaker and a microphone by means of an adaptive filter. The echo signal can be canceled successfully when the modeling filter approaches the true echo path. Another way to mitigate the echo effect is through echo suppression. Unlike an AEC, an acoustic echo suppressor (AES) achieves echo attenuation by means of spectral modification. In this paper, we propose an AES without a need for the computationally complex task of acoustic echo path estimation. Instead of identifying the echo path impulse response, the proposed method estimates only the properties of the echo path which are needed for effective echo suppression. These are a delay parameter and a filter mimicking the coloration effect of the echo path on the loudspeaker signal. The gain filter for the AES is computed using the estimated delay and coloration effect filter. Simulations and experiments using a real-time telecommunication system indicate that the proposed scheme is effective for suppressing echo, supports duplex communication, and is less sensitive to echo path changes than a conventional AEC. 1.
Characterization of Granular Cold Water‐Soluble Starch (1986)

Abstract Granular, cold water soluble (GCWS) wheat and corn starch can be prepared by heating in aqueous alcohol and evaporating the solvents. GCWS starch was characterized by light and electron microscopy, x‐ray diffraction, HPLC, enzymic hydrolysis, the Brabender Amylograph, and differential scanning calorimetry.
The Use of Topographical Constraints In Receptor Mapping:  Investigation of the Topographical Requirements of the Tryptophan 30 Residue for Receptor Binding of Asp-Tyr-<scp>d</scp>-Phe-Gly-Trp-(<i>N</i>-Me)Nle-Asp-Phe-NH<sub>2</sub>(SNF 9007), a Cholecystokinin (26−33) Analogue That Binds to both CCK-B and δ-Opioid Receptors (1996)

The cholecystokinin (26-33) [CCK (26-33)] octapeptide analog Asp-Tyr-D-Phe-Gly-Trp(N-Me)-Nle-Asp-Phe-NH2 (SNF 9007) is a potent and selective ligand for both the CCK-B and delta-opioid receptors. Pharmacological studies of SNF 9007 suggest a relationship between the ligand requirements of CCK-B and delta-opioid receptors, which further implies a possible structural relationship between these receptors. We have utilized topographical constrainment of the important Trp30 residue to investigate structural features of SNF 9007 that would distinguish between binding requirements in this region for the CCK-B and delta-opioid receptors. Thus, the four optically pure isomers of beta-MeTrp were substituted for L-Trp30 of SNF 9007. Receptor binding results suggest that the preferred topography of the Trp30 residue for CCK-B receptor binding may be the 2S,3S (erythro-L) configuration whereas for the delta-opioid receptor it may be the 2S,3R (threo-L) configuration. Molecular modeling studies of these ligands further support the recently revised receptor-bound model for CCK-B octapeptide ligands (Kolodziej et al. J. Med. Chem. 1995, 38, 137-149) and are in good agreement with the DPDPE-delta opioid receptor "template" model (Nikiforovich et al. Biopolymers 1991, 31, 941-955).
Data consistency‐driven determination of ‐fluctuations in gradient‐echo MRI (2018)

Based on the consistency navigator, an accurate estimation of the spatiotemporal characteristics of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>B</mml:mi><mml:mn>0</mml:mn></mml:msub></mml:math> -fluctuations and correction of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>T</mml:mi><mml:mn>2</mml:mn><mml:mo>*</mml:mo></mml:msubsup></mml:math> -weighted images has been demonstrated.
Selective isolation of live/dead cells using contactless dielectrophoresis (cDEP) (2010)

Contactless dielectrophoresis (cDEP) is a recently developed method of cell manipulation in which the electrodes are physically isolated from the sample. Here we present two microfluidic devices capable of selectively isolating live human leukemia cells from dead cells utilizing their electrical signatures. The effect of different voltages and frequencies on the gradient of the electric field and device performance was investigated numerically and validated experimentally. With these prototype devices we were able to achieve greater than 95% removal efficiency at 0.2-0.5 mm s(-1) with 100% selectivity between live and dead cells. In conjunction with enrichment, cDEP could be integrated with other technologies to yield fully automated lab-on-a-chip systems capable of sensing, sorting, and identifying rare cells.
CNTs in the context of EUV pellicle history (Conference Presentation) (2018)

In the early 2000s, membranes both thin enough to transmit EUV light and strong enough to be free-standing at mask dimensions did not exist. The lithography community assumed that defect control for photomasks would be achieved, not with a pellicle, but with a clean scanner environment, thermophoretic protection and a removable pellicle.<sup>1</sup> In 2006, Intel published their research on an EUV pellicle.<sup>2</sup> Since then, an international development effort on EUV pellicle membranes has spanned a range of materials and fabrication approaches. Not only materials, but also the requirements of the EUV pellicle membrane have evolved over time. Imec’s pellicle work based on carbon nanotubes (CNTs) started in 2015, and is placed in relation to the rich history of EUV pellicles. CNTs are one-atom-thick carbon sheets rolled into tubes. The CNTs can be single- or multi-walled and can vary in diameter and in length. These engineered CNTs can be arranged in different configurations to form membranes of different densities. Thus, the CNT membrane’s properties can be fundamentally changed to meet the EUV pellicle targets for properties like transmittance. The historical trends in EUV pellicle membrane development are presented and the CNT membranes are described in that context.
SU-G-BRC-01: A Data-Driven Pre-Optimization Method for Prediction of Achievability of Clinical Objectives in IMRT (2016)

Purpose: We propose a novel data-driven method to predict the achievability of clinical objectives upfront before invoking the IMRT optimization. Methods: A new metric called “Geometric Complexity (GC)” is used to estimate the achievability of clinical objectives. Here, GC is the measure of the number of “unmodulated” beamlets or rays that intersect the Region-of-interest (ROI) and the target volume. We first compute the geometric complexity ratio (GCratio) between the GC of a ROI (say, parotid) in a reference plan and the GC of the same ROI in a given plan. The GCratio of a ROI indicates the relative geometric complexity of the ROI as compared to the same ROI in the reference plan. Hence GCratio can be used to predict if a defined clinical objective associated with the ROI can be met by the optimizer for a given case. Basically a higher GCratio indicates a lesser likelihood for the optimizer to achieve the clinical objective defined for a given ROI. Similarly, a lower GCratio indicates a higher likelihood for the optimizer to achieve the clinical objective defined for the given ROI. We have evaluated the proposed method on four Head and Neck cases using Pinnacle3 (version 9.10.0) Treatment Planning System (TPS). Results: Out of the total of 28 clinical objectives from four head and neck cases included in the study, 25 were in agreement with the prediction, which implies an agreement of about 85% between predicted and obtained results. The Pearson correlation test shows a positive correlation between predicted and obtained results (Correlation = 0.82, r2 = 0.64, p < 0.005). Conclusion: The study demonstrates the feasibility of the proposed method in head and neck cases for predicting the achievability of clinical objectives with reasonable accuracy.
Transmission factor of material Bartonella henselae isolated from cats in Zimbabwe (1998)

used was identical to that used in adult replica and player’s shirts. The material was 85% polyester, thin, predominantly white and constructed in vertical bands of differing thickness. The thicker bands are about 6 mm wide and 0·35 mm thick, the thinner bands being 3 mm across, 0·30 mm thick and with a more open weave. Ultraviolet light from a UV90 Clinical Photo-irradiator (Applied Photophysics Ltd) was shone through the material via a fibre-optic cable. Measurements of transmission were made with a Solatell Sola-Scope spectroradiometer (4D Controls Ltd) with a single layer of material resting flat against the sensor without being stretched. The figure shows the transmission factors of the material bands. It can be seen that the thin bands allow about 15–20% transmission at wavelengths above 280 mm whereas the thick bands allow transmission of 8–10%. The UPF was calculated for the range 260–400 nm and found to be 5 for the thin bands and 11 for the thick bands. The most important factor affecting the UV protection afforded by clothing is the closeness of the weave of the material as the light is scattered through the interstices, although darker colours tend to transmit less UV than lighter ones.