gebhart/patrepeval huggingface dataset:
An Orthogonal Resource Allocation Algorithm to Improve the Performance of OFDMA-Based Cellular Wireless Systems Using Relays (2008)

For the next generation wireless communication systems, inter-cell interference (ICI) is the main source of performance degradation in mobile stations, especially, cell-edge mobile stations. This paper presents a novel orthogonal resource allocation algorithm (ORAA) for our proposed system architecture, termed the OFDMA-based cellular wireless system architecture using relays (OCWSAR). By using relays to cover the cell-edge areas and a robust algorithm with priority resource allocation, the ICI of the system is significantly reduced, while the sector frequency reuse factor is maintained at 1. A system-level simulator is developed in a multi-cell/multi-user environment, where the effect of the proposed ORAA can be evaluated precisely in the presence of inter-cell interference (ICI). Furthermore, the simulation results assure that the new system architecture with the associated algorithm yield higher SINR and data throughput for cell-edge users.
Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase. (1985)

We have cloned CDC9, the structural gene for Saccharomyces cerevisiae DNA ligase, and investigated its transcriptional regulation both as a function of cell cycle stage and after UV irradiation. The steady-state level of DNA ligase mRNA increases at least fourfold in late G1, after the completion of start but before S phase. This high level of CDC9 mRNA then decays with an apparent half-life of ca. 20 min and remains at a low basal level throughout the rest of the cell cycle. The accumulation of CDC9 mRNA in late G1 is dependent upon the completion of start but not the CDC7 and CDC8 functions. Exposure of cells to UV light elicits an eightfold increase in DNA ligase mRNA levels.
Nanoporous gold nanoparticles (2012)

Nanoporous gold nanoparticles are fabricated by combining a thermal dewetting process of Au/Ag bi-layer films and a dealloying process. As the gold concentration is small enough within the dewetted nanoparticles, a complete chemical removal of Ag can be achieved and there is a size shrinking during the dealloying process. The nanoporous gold nanoparticles possess a much higher surface-to-volume ratio than bulk nanoporous gold films or gold nanoparticles. The nanoporous nanoparticles have a potential usage in chemical, photonic, and catalytic applications.
An approach towards an agent computing environment (2003)

We devise a mobile agent middleware architecture for supporting distributed applications in a wide-area network. The architecture provides a structural framework for functional components that support mobile agents in asymmetric networking environments.
The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery (2009)

As the major etiological agent of the common cold, human rhinoviruses (HRV) cause millions of lost working and school days annually. Moreover, clinical studies proved an association between harmless upper respiratory tract infections and more severe diseases e.g. sinusitis, asthma, and chronic obstructive pulmonary disease. Both the medicinal and socio-economic impact of HRV infections and the lack of antiviral drugs substantiate the need for intensive antiviral research. A common structural feature of the approximately 100 HRV serotypes is the icosahedrally shaped capsid formed by 60 identical copies of viral capsid proteins VP1-4. The capsid protects the single-stranded, positive sense RNA genome of about 7,400 bases in length. Both structural as well as nonstructural proteins produced during the viral life cycle have been identified as potential targets for blocking viral replication at the step of attachment, entry, uncoating, RNA and protein synthesis by synthetic or natural compounds. Moreover, interferon and phytoceuticals were shown to protect host cells. Most of the known inhibitors of HRV replication were discovered as a result of empirical or semi-empirical screening in cell culture. Structure-activity relationship studies are used for hit optimization and lead structure discovery. The increasing structural insight and molecular understanding of viral proteins on the one hand and the advent of innovative computer-assisted technologies on the other hand have facilitated a rationalized access for the discovery of small chemical entities with antirhinoviral (anti-HRV) activity. This review will (i) summarize existing structural knowledge about HRV, (ii) focus on mechanisms of anti-HRV agents from synthetic and natural origin, and (iii) demonstrate strategies for efficient lead structure discovery.
Pipe routing-path planning (with many constraints) (2002)

An implemented system for designing pipe layouts automatically using robot path planning techniques is described. The authors introduce a new approach to pipe layout design automation in which pipe routes are treated as paths left behind by rigid objects (robots). They have implemented this approach in a basic pipe router, which is also described, and have extended this router in order to make it capable of treating a variety of other constraints which are typical of practical pipe layout design problems. These constraints relate to the process carried out in the pipes, to the design of their mechanical support, and to the constructability and the ease of operation and maintenance of the designed pipe systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Simplified Phenotyping with Dextromethorphan by Thin-Layer Chromatography (1988)

Identifying individuals with a deficient capacity for oxidative drug metabolism is of increasing clinical importance. Dextromethorphan (DM) is gaining wide acceptance as a probe drug to characterize individual expression of a specific cytochrome P-450 isozyme. The thin-layer chromatography (TLC) technique described in the present study is a rapid and inexpensive alternative to the methods currently available for assessing the urinary metabolic profile of DM. Sixty-five healthy volunteers participated in the study by ingesting 213 mmol DM and collecting all urine for the ensuing 8 h. Urine samples were analyzed by TLC and high-performance liquid chromatography (HPLC) after treatment with beta-glucuronidase. Based on the relative color intensities of DM and its O-demethylated metabolite, dextrorphan, the TLC analysis provided an accurate phenotype assessment. A greater intensity of the parent drug relative to the metabolite indicates a poor metabolizer phenotype whereas a reversed relative intensity indicates the extensive metabolizer phenotype. The phenotype assignments made by TLC were verified by comparison with the quantitative results (based on metabolic ratios) obtained from HPLC analysis. Complete agreement was found between the two methods. The routine implementation of phenotype determination into clinical protocols can be realized with this facile TLC technique.
Translation of chloroplast <i>psbA</i> mRNA is regulated by signals initiated by both photosystems II and I (2001)

Light controls the translation of several mRNAs in fully developed chloroplasts via at least two regulatory pathways. In the first, the light signal is transduced as a thiol-mediated signal that modulates translation in parallel to light intensity. The second light-controlled pathway, termed priming, is a prerequisite to the thiol-mediated regulatory pathway. Light regulation is rapid and requires intrachloroplast photoreceptor(s). To delineate the signaling pathways controlling each of these regulatory events, we assayed the effect of photosynthetic inhibitors and electron donors on the translation of chloroplastic psbA mRNA. We show that the thiol-mediated signal is generated by photosystem I and transduced by vicinal dithiol-containing proteins. We also found that the priming signal probably initiates on reduction of plastoquinone. These findings suggest that translation of chloroplast psbA mRNA is controlled by both linear photosynthetic electron transport, exerted by the reduction of the ferredoxin-thioredoxin system, and the relative activities of photosystems I and II, signaled by the redox state of the plastoquinone pool. These data underscore the function of the light-capturing reactions of photosynthesis as chloroplast photoreceptors.
Influence of Photosensitizer Solvent on the Mechanisms of Photoactivated Killing of <i>Enterococcus faecalis</i> (2007)

This study evaluated the mechanisms involved and the influence of photosensitizer solvent in the killing of Enterococcus faecalis using photodynamic therapy (PDT). Enterococcus faecalis cells incubated with 100 microm methylene blue dissolved in water and in MIX (a mixture of glycerol:ethanol:water) were irradiated with 664 nm diode laser (63.69 J cm(-2)). The effect of PDT on the viability of bacteria, and the functional integrity of cell wall, chromosomal DNA and membrane proteins were analyzed. The bactericidal action of PDT was significantly higher when a MIX-based photosensitizer solvent was used (P<0.001). Fluorimetric and fluorescence microscopy-based analysis showed the functional impairment of E. faecalis cell wall which was significantly higher when a MIX-based photosensitizer solvent was used (P<0.001). PDT with MIX-based photosensitizer solvent showed extensive damage to chromosomal DNA. However, both PDT conditions showed similar trend in the degradation of membrane proteins, although cross-linked proteins were evident only in PDT conducted with MIX-based photosensitizer solvent. The findings from our study showed that PDT destroyed the functional integrity of cell wall, DNA and membrane proteins of E. faecalis. The degrees of damage on these targets were influenced by the photosensitizer solvent used during PDT.
Magnesium in perinatal care and infant health. (1993)

Magnesium, the second most abundant intracellular cation, is essential for life. The consequences of deficiency are severest in the smallest and youngest members of each species and may include sudden unexpected death. Magnesium deficiency, usually diagnosed by hypomagnesemia, may be congenital, as in premature infants, infants of magnesium-deficient mothers and infants with intrauterine growth retardation. It may be acquired or caused by low magnesium intake, the use of magnesium-wasting drugs, illness provoking gastrointestinal or renal losses of the mineral, or high metabolic demands imposed by catch-up growth or postsurgical healing. Finally, the deficiency may be conditioned, caused by excessive dietary calcium, phosphorus or protein in relation to dietary magnesium, especially during a period of rapid growth or tissue repair. Magnesium therapy is safe when a low dosage is given with monitoring of plasma or serum magnesium levels, with occasional checking of calcium and potassium levels. A parenteral dose of 0.1 ml/kg/day of 50% magnesium sulfate USP (approx. 0.2 mmol/kg/day or 0.4 mEq/kg/day) may be given for 5 dose days. An oral dose of 1.0 ml of 10% magnesium chloride solution providing 0.5 mmol/kg/day magnesium or 1.0 ml/kg/day of 10% magnesium chloride USP (0.5 mmol/kg/day) or magnesium magonate (Magonate) 1.0 ml/kg/day (0.45 mmol/kg/day) may be given for extended periods; higher doses may be required for malabsorption syndromes. Hypermagnesemia, which usually results from magnesium overdosage or inadequate renal function, is a potential threat to neonates born to magnesium-treated eclamptic mothers. Most show marked improvement after 36 h of conservative management that includes calcium salts and intravenous infusions of glucose and saline, but obtunded neonates may require dialysis.
A Study on Immersion and Presence of a Portable Hand Haptic System for Immersive Virtual Reality (2017)

This paper proposes a portable hand haptic system using Leap Motion as a haptic interface that can be used in various virtual reality (VR) applications. The proposed hand haptic system was designed as an Arduino-based sensor architecture to enable a variety of tactile senses at low cost, and is also equipped with a portable wristband. As a haptic system designed for tactile feedback, the proposed system first identifies the left and right hands and then sends tactile senses (vibration and heat) to each fingertip (thumb and index finger). It is incorporated into a wearable band-type system, making its use easy and convenient. Next, hand motion is accurately captured using the sensor of the hand tracking system and is used for virtual object control, thus achieving interaction that enhances immersion. A VR application was designed with the purpose of testing the immersion and presence aspects of the proposed system. Lastly, technical and statistical tests were carried out to assess whether the proposed haptic system can provide a new immersive presence to users. According to the results of the presence questionnaire and the simulator sickness questionnaire, we confirmed that the proposed hand haptic system, in comparison to the existing interaction that uses only the hand tracking system, provided greater presence and a more immersive environment in the virtual reality.
Effect of trehalose accumulation on response to saline stress in <i>Saccharomyces cerevisiae</i> (2009)

To examine the effect of trehalose accumulation on response to saline stress in Saccharomyces cerevisiae, we constructed deletion strains of all combinations of the trehalase genes ATH1, NTH1 and NTH2 and examined their growth behaviour and intracellular trehalose accumulation under non-stress and saline-stress conditions. Saline stress was induced in yeast cells by NaCl addition at the exponential growth phase. All deletion strains showed similar specific growth rates and trehalose accumulation to their parent strain under non-stress conditions. However, under the saline stress condition, one single deletion strain, nth1Delta, two double deletion strains, nth1Delta ath1Delta and nth1Delta nth2Delta, and the triple deletion strain nth1Deltanth2Delta ath1Delta, all of which carry the nth1Delta deletion, showed increased trehalose accumulation as compared to the parent and other deletion strains. In particular, our statistical analysis revealed that the triple deletion strain showed a higher growth rate under the saline stress condition than the parent strain. Moreover, some deletion strains showed further trehalose accumulation under non-stress conditions by overexpression of the TPS1 or TPS2 genes encoding the enzymes related to trehalose biosynthesis at the mid-exponential phase. Such increased trehalose accumulation prior to NaCl addition could improve the growth of these strains under saline stress. Our results indicate that high trehalose accumulation prior to NaCl addition, rather than after NaCl addition, is necessary to achieve high growth activity under stress conditions.
Vorbemerkung (2008)

Die vielfach konstatierten Veränderungen, denen Arbeit im Zeitalter des »Shareholder-value-Kapitalismus« unterworfen ist, führen unzweifelhaft zu neuen Belastungen und Restriktionen für die Beschäftigten. Aber der Prozess hat auch eine Kehrseite: Der Versuch, subjektive Produktivitätspotenziale zu aktivieren, hebt die Individuen auch aus ihrer früheren Rolle als bloße Objekte betrieblicher Rationalisierung heraus. Es eröffnen sich subjektive Orientierungen; Interessenlagen kommen ins Spiel, die in den Sphären außerhalb der Arbeit situiert sind. Das Verhältnis von Ökonomie und Lebensweise wird zum neuen Bezugspunkt betrieblicher (Ver-)Nutzungsstrategien von Arbeit. Die Autor/inn/en dieses Buchs fragen sowohl nach der restriktiven wie auch nach der »widerständigen« Seite, nach den Handlungsstrategien und dem »Eigensinn« der Arbeitenden. Dabei zeigt sich, dass dem Kriterium Sicherheit zentrale Bedeutung zukommt. Das gilt insbesondere (aber nicht nur) für weibliche Beschäftigte. Die betriebliche Arbeits- und Geschlechterpolitik ist darauf nicht eingestellt, die betrieblichen Akteure stehen hier vor neuen Herausforderungen. Das wird beispielhaft am Transformationsprozess der Deutschen Bahn AG empirisch untersucht.
Early B-Cell Factor, E2A, and Pax-5 Cooperate To Activate the Early B Cell-Specific <i>mb-1</i> Promoter (2002)

Previous studies have suggested that the early-B-cell-specific mb-1(Igalpha) promoter is regulated by EBF and Pax-5. Here, we used in vivo footprinting assays to detect occupation of binding sites in endogenous mb-1 promoters at various stages of B-cell differentiation. In addition to EBF and Pax-5 binding sites, we detected occupancy of a consensus binding site for E2A proteins (E box) in pre-B cells. EBF and E box sites are crucial for promoter function in transfected pre-B cells, and EBF and E2A proteins synergistically activated the promoter in transfected HeLa cells. Other data suggest that EBF and E box sites are less important for promoter function at later stages of differentiation, whereas binding sites for Pax-5 (and its Ets ternary complex partners) are required for promoter function in all mb-1-expressing cells. Using DNA microarrays, we found that expression of endogenous mb-1 transcripts correlates most closely with EBF expression and negatively with Id1, an inhibitor of E2A protein function, further linking regulation of the mb-1 gene with EBF and E2A. Together, our studies demonstrate the complexity of factors regulating tissue-specific transcription and support the concept that EBF, E2A, and Pax-5 cooperate to activate target genes in early B-cell development.
Population-Based Case-Control Study of Amyotrophic Lateral Sclerosis in Western Washington State. II. Diet (2000)

The association of nutrient intake with the risk of amyotrophic lateral sclerosis (ALS) was investigated in a population-based case-control study conducted in three counties of western Washington State from 1990 to 1994. Incident ALS cases (n = 161) were identified and individually matched on age and gender to population controls (n = 321). A self-administered food frequency questionnaire was used to assess nutrient intake. Conditional logistic regression analysis was used to compute odds ratios adjusted for education, smoking, and total energy intake. The authors found that dietary fat intake was associated with an increased risk of ALS (highest vs. lowest quartile, fiber-adjusted odds ratio (OR) = 2.7, 95% confidence interval (CI): 0.9, 8.0; p for trend = 0.06), while dietary fiber intake was associated with a decreased risk of ALS (highest vs. lowest quartile, fat-adjusted OR = 0.3, 95% CI: 0.1, 0.7; p for trend = 0.02). Glutamate intake was associated with an increased risk of ALS (adjusted OR for highest vs. lowest quartile = 3.2, 95% CI: 1.2, 8.0; p for trend < 0.02). Consumption of antioxidant vitamins from diet or supplement sources did not alter the risk. The positive association with glutamate intake is consistent with the etiologic theory that implicates glutamate excitotoxicity in the pathogenesis of ALS, whereas the associations with fat and fiber intake warrant further study and biologic explanation.
Annexure Five (B) : Stakeholder’s Concerns and Opinion (2019)

The Development objective of the Odisha integrated irrigated project on climate resilient agriculture for India is to intensify and diversify agriculture production, enhanceclimate resilience and improve water productivity in selected cascades of Odisha. some of the negative impacts are include: (i) use of fertile agricultural land for construction ofinfrastructure may alter the land use pattern and impact on crop production; (ii) generated construction waste like sand, stone, wood chips (from centering, shuttering work), cut piece of reinforcement and mesh wire if not removed after completion of work may create inconvenience to local people, health hazard; (iii) residual material may wash off and chock nearby drainage system during rainy season; (iv) generation and disposal of biodegradable food waste; (v) use of fertile agricultural land for construction of chc may alter the land use pattern and impact on crop production; (vi) use of asbestos material; (vii) residual material may wash off and chock nearby drainage system during rainy season; (viii) high moisture trash fish feed becomes mouldy easily; (ix) health hazard and spoilage due to unhygienic practice and spoilage due to non maintenance of suitable temperature in transportation vehicle; (x) degradation of soil fertility due to increased application of pesticide and chemical fertilizer; (xi) use of fertile agricultural land for construction of infrastructure may alter the land use pattern and impact on crop production; (xii) use of fertile agricultural land for construction of infrastructure may alter the land use pattern and impact on crop production; (xiii) odour pollution from generated food waste if not disposed in regular interval; some of the mitigation measures are include: (i) use of private agricultural land shall be avoided, govt. barren land shall be used; (ii) food waste shall be collected separately and sold to organization preparing organic waste; (iii) use vegetarian fish feed which has a low moisture content and preservation treatment is usually not necessary; (iv) regular removal and drying of waste material and use it as cooking fuel; (v) cleaning and disinfection of mushroom grown area to maintain hygiene condition; (vi) possibility shall be explored for using of vegetation waste as compost material; (vii) vegetable (food) waste shall be stored at earmarked area and disposed to a designated place; (viii) organic aqueous waste shall be stored at earmarked area and disposed to a designated place; (ix) contractor and its workers will be educated or sensitized on endangered or vulnerable species and its protection measures
A floating-gate-MOS-based multiple-valued associative memory (2002)

A digit-serial, multiple-valued associative memory VLSI for high-speed information search is presented. Input and output data of a processing element (PE) in the VLSI are directly encoded by appropriate multiple-valued digits, respectively, so that search operations are efficiently described by the combination of a multiple-valued down literals and pass gates. Moreover, multiple-valued memory information is stored in each PE by programming the threshold of the down literal which can be easily implemented using special MOS transistors, called floating-gate MOS transistors. It is demonstrated that the number of interconnections and transistors in the 5-valued associative memory can be reduced to 25% and 53%, respectively, in comparison with the corresponding binary implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ANALISIS PERILAKU SEKSUAL REMAJA LAKI-LAKI DAN PEREMPUAN DI KOTA AMBON (2023)

Masa remaja ditandai dengan mulai berani untuk menjalin hubungan khusus dengan lawan jenis yang biasa disebut pacaran. Pacaran merupakan salah satu cara yang paling banyak dilakukan dan paling mudah untuk menggiring remaja ke perilaku seksual berisiko. Tujuan penelitian adalah untuk menganalisis perilaku seksual remaja laki-laki dan perempuan di Kota Ambon. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Populasi penelitian merupakan remaja di Kota Ambon. Sampel penelitian adalah siswa Sekolah Menengah Atas (SMA)/sederajat di Kota Ambon. Penelitian menggunakan quote sampling dengan sampel sebanyak 50 siswa tiap sekolah. Jumlah sampel sebanyak 1.000 siswa SMA/sederajat yang diambil dari 20 sekolah di Kota Ambon. Hasil penelitian menemukan bahwa sekitar 62,1% remaja pernah menonton video porno dan sekitar 42,7% beranggapan bahwa berpelukan adalah hal yang biasa, sekitar 10,8% remaja pernah melakukan hubungan seksual pranikah. Remaja laki-laki yang memiliki perilaku seksual berisiko sebesar 61,4% sedangkan remaja perempuan yang memiliki perilaku seksual berisiko yaitu 26,4%. Kesimpulannya adalah ada hubungan jenis kelamin dengan perilaku seksual berisiko pada remaja di Kota Ambon (p<0,001). Disarankan bagi guru dan orang tua dapat mengawasi perilaku remaja sehingga tidak terjerumus melakukan perilaku seksual berisiko.