gebhart/patrepeval huggingface dataset:
Using entropy to distinguish shape versus text in hand-drawn diagrams (2009)

Most sketch recognition systems are accurate in recognizing either text or shape (graphic) ink strokes, but not both. Distinguishing between shape and text strokes is, therefore, a critical task in recognizing hand-drawn digital ink diagrams that contain text labels and annotations. We have found the ‘entropy rate ’ to be an accurate criterion of classification. We found that the entropy rate is significantly higher for text strokes compared to shape strokes and can serve as a distinguishing factor between the two. Using a single feature – zero-order entropy rate – our system produced a correct classification rate of 92.06 % on test data belonging to diagrammatic domain for which the threshold was trained on. It also performed favorably on an unseen domain for which no training examples were supplied. 1
Needs and Artificial Intelligence (2022)

Throughout their history, homo sapiens have used technologies to better satisfy their needs. The relation between needs and technology is so fundamental that the US National Research Council defined the distinguishing characteristic of technology as its goal "to make modifications in the world to meet human needs". Artificial intelligence (AI) is one of the most promising emerging technologies of our time. Similar to other technologies, AI is expected "to meet [human] needs". In this article, we reflect on the relationship between needs and AI, and call for the realisation of needs-aware AI systems. We argue that re-thinking needs for, through, and by AI can be a very useful means towards the development of realistic approaches for Sustainable, Human-centric, Accountable, Lawful, and Ethical (HALE) AI systems. We discuss some of the most critical gaps, barriers, enablers, and drivers of co-creating future AI-based socio-technical systems in which [human] needs are well considered and met. Finally, we provide an overview of potential threats and HALE considerations that should be carefully taken into account, and call for joint, immediate, and interdisciplinary efforts and collaborations.
The Effect of Prolonged Static and Cyclic Stretching on Ankle Joint Stiffness, Torque Relaxation, and Gait in People With Stroke (2002)

These preliminary data from a very small sample of people with stroke indicate that ankle joint stiffness decreases after both prolonged static and cyclic stretches; however, neither technique appears to be better at reducing stiffness in people with stroke. Torque relaxation is greater after static stretching than after cyclic stretching, and walking speed does not appear to be influenced by the stretching treatments used in our study.
Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease (2018)

Alzheimer's disease (AD) represents a major healthcare burden with no effective treatment. The glutamate modulator, riluzole, was shown to reverse many AD-related gene expression changes and improve cognition in aged rats. However, riluzole's effect on amyloid beta (Aβ) pathology, a major histopathological hallmark of AD, remains unclear. 5XFAD transgenic mice, which harbor amyloid β precursor protein (APP) and presenilin mutations and exhibit early Aβ accumulation, were treated with riluzole from 1 to 6 months of age. Riluzole significantly enhanced cognition and reduced Aβ42, Aβ40, Aβ oligomers levels, and Aβ plaque load in 5XFAD mice. RNA-Sequencing showed that riluzole reversed many gene expression changes observed in the hippocampus of 5XFAD mice, predominantly in expression of canonical gene markers for microglia, specifically disease-associated microglia (DAM), as well as neurons and astrocytes. Central to the cognitive improvements observed, riluzole reversed alterations in NMDA receptor subunits gene expression, which are essential for learning and memory. These data demonstrate that riluzole exerts a disease modifying effect in an Aβ mouse model of early-onset familial AD.
A note on lactobacilli and β‐glucuronidase activity in the intestinal contents of mice (1993)

A comparison was made of caecal beta-glucuronidase activity in the caecal contents of mice with or without lactobacilli as members of the normal microflora. Male mice that did not have lactobacilli as intestinal inhabitants had approximately 52% more caecal beta-glucuronidase activity than their female counterparts. Colonization of male mice by lactobacilli reduced the beta-glucuronidase activity to that of female mice.
Mining Frequent Itemsets from Data Streams with a Time-Sensitive Sliding Window (2005)

Mining frequent itemsets has been widely studied over the last decade. Past research focuses on mining frequent itemsets from static databases. In many of the new applications, data flow through the Internet or sensor networks. It is challenging to extend the mining techniques to such a dynamic environment. The main challenges include a quick response to the continuous request, a compact summary of the data stream, and a mechanism that adapts to the limited resources. In this paper, we develop a novel approach for mining frequent itemsets from data streams based on a time-sensitive sliding window model. Our approach consists of a storage structure that captures all possible frequent itemsets and a table providing approximate counts of the expired data items, whose size can be adjusted by the available storage space. Experiment results show that in our approach both the execution time and the storage space remain small under various parameter settings. In addition, our approach guarantees no false alarm or no false dismissal to the results yielded.
In vitro studies on antibacterial, antifungal, and cytotoxic properties of Leucas aspera (2012)

The leaves of the plant Leucas aspera belonging to the family Lamiaceae was studied to determine the in vitro antibacterial, antifungal, and cytotoxic properties. All extracts showed remarkable antibacterial activity against all of the studied organisms except Escherichia coli. Methanol extract showed stronger activity compared to ethyl acetate and petroleum ether extracts. It showed highest activity against Pseudomonas aeruginosa with zone of inhibition of 15 mm. The standard chloramphenicol did not show any activity against Shigella sonnei. But all the extracts showed moderate activity against this pathogen with zone of inhibition ranging from 10 to 13 mm. None of the extracts has shown any significant antifungal activity against the fungi. Incase of brine shrimp lethality bioassay, methanol extract showed the strongest cytotoxic effect with LC50 value of 4.28 μg/ml which is followed by ethyl acetate extract with LC50 value of 5.36 μg/ml. Thus it can be inferred that this plant may be a potential source of novel bioactive compounds.
Immunoactive, medicinal properties of mushroom and herb polysaccharides and their potential use in chicken diets (2003)

Chinese natural medicinal products as feed supplements have been used as growth and health promoters in farm animals in China for centuries. A current estimation of the number of Chinese natural medicines ranges between 6,000 and 8,000, of which less than 5% has immuno-active properties. Most of these medicinal products originate from plants. Polysaccharides are considered to be the most important components, which may act as immune enhancers or immuno-modulators. The relationship between polysaccharide structure and bio-activity is, however, not well understood. In this review, immune activities of the polysaccharides from two mushrooms, Lentinus edodes and Tremella fuciformis, and a herb, Astragalus membranaceus radix, are reported, based on studies in chickens, mice, rats and humans. It can be concluded from these studies that polysaccharides derived from these products can play important roles in: (1) stimulating the growth of immune organs such as spleen, thymus and bursa; (2) increasing the number and activities of many interdependent cell types such as T, B lymphocytes, macrophages, natural killer (NK) cells and lymphokine-activated killer (LAK) cells; (3) enhancing T-cell mediated immune response, such as an increased rate of T-lymphocyte transformation and proliferation; (4) enhancing humoral immune response, such as spleen and serum antibody production, the number of haemolytic plague forming cells (PFC) and haemolysin production and (5) inducing secretion and production of cytokines and complements of T-cells and NK cells.Today's poultry producers are confronted by numerous prophylactic techniques to prevent diseases. The immuno-active polysaccharides from mushrooms and herbs might be good candidates as health promoting feed additives in poultry diets. Further studies are needed to investigate the effects of such bioactive components to improve productive performance in chicken and to elucidate the possible modes of action related to the gut ecosystem and the immune response.
Electron field emission from room temperature grown carbon nanofibers (2004)

The observation of field induced electron emission from room temperature grown carbon nanofibers at low (5 V/μm) macroscopic electric fields is reported. The nanofibers were deposited using methane as a source gas in a conventional rf plasma enhanced chemical vapor deposition reactor using a Ni metal catalyst previously subjected to an Ar plasma treatment. Analysis of the scanning electron microscopy images of the nanofibers show them to possess an average diameter of 300 nm and that the nanofibers are observed to be radially dispersed over an area of 50 μm in diameter. No evidence of hysteresis in the current-voltage characteristic or conditioning of the emitters is observed. The mechanism for emission at low fields is attributed to field enhancement at the tips rather than from the surrounding amorphous carbon film which is shown to have a higher threshold field (20 V/μm) for emission.
A Model Driven Architecture for Enterprise Application Integration (2006)

To achieve greater automation of their business processes, organizations face the challenge of integrating disparate systems. In attempting to overcome this problem, organizations are turning to new integration software called Enterprise Application Integration (EAI). Implementing EAI is a complex task involving both technological and business challenges and requires appropriate EAI architecture. This paper first provides an overview of current approaches to enterprise application integration together with an assessment of their strengths and weaknesses. It then proposes a new enterprise application architecture, based on the idea of OMG’s Model Driven Architecture, to structure the EAI problem into five general types of model. This architecture is developed in response to the need to separate the technological aspect from the business aspect so that the both can evolve independently. The success of EAI lies in its resilience to the both technological and business changes.
Radiotherapy planning: direct tumor location on simulation and port films using CT. Part I. Principles. (1986)

Although there have been great advances in cancer diagnosis in recent years, it remains difficult to transfer tumor location information from cross-sectional computed tomographic (CT) scans or magnetic resonance images to the simulation and verification films used in planning radiotherapy. A newly developed system uses radioopaque markers attached to the patient as reference points. These markers are identified on both CT scans and simulation films and their locations entered into the treatment planning computer. The tumor and any desired normal structures are then outlined manually on each CT section. Transparent overlays produced by the computer show the position of the reference markers and tumor outlines for any combination of gantry angles and source-film distance. Because the overlays are scaled to the simulation films, the reference points enable precise alignment of overlay and film. The tumor outline thus appears on the simulation or verification films exactly as it is "seen" by the therapy beam, making field verification straightforward and accurate, even on oblique films.
[Knockout of tyrR gene in Escherichia coli and its effects on the phenylalanine biosynthesis]. (2003)

TyrR is a global regulation protein encoded by tyrR gene which controls several transcriptional units involving biosynthesis and transportation of aromatic amino acids in Escherichia coli. In this work, the tyrR gene was knocked out by a double-cross homologous recombination. The tyrR- mutant was verified by structural identification by PCR and sequencing, and functional demonstration using lacZ reporter gene. In tyrR- mutant, the activities of two key enzymes in the phenylalanine biosynthesis pathway, whose expression was controlled by TyrR, DAHPS and AT, had been shown to elevate by a 1.08-fold and 2.70-fold compared with the parent strain, respectively. The yield of phenylalanine biosynthesis in the mutant was 1.59 times higher than that of wild type strain. The repression on the transcription of aroP, encoding an aromatic amino acid permease, was eliminated, resulting in a 70.2% increase of the aromatic amino acid transportation in tyrR- mutant strain.
Microbial Reprogramming Inhibits Western Diet-Associated Obesity (2013)

A recent epidemiological study showed that eating 'fast food' items such as potato chips increased likelihood of obesity, whereas eating yogurt prevented age-associated weight gain in humans. It was demonstrated previously in animal models of obesity that the immune system plays a critical role in this process. Here we examined human subjects and mouse models consuming Westernized 'fast food' diet, and found CD4(+) T helper (Th)17-biased immunity and changes in microbial communities and abdominal fat with obesity after eating the Western chow. In striking contrast, eating probiotic yogurt together with Western chow inhibited age-associated weight gain. We went on to test whether a bacteria found in yogurt may serve to lessen fat pathology by using purified Lactobacillus reuteri ATCC 6475 in drinking water. Surprisingly, we discovered that oral L. reuteri therapy alone was sufficient to change the pro-inflammatory immune cell profile and prevent abdominal fat pathology and age-associated weight gain in mice regardless of their baseline diet. These beneficial microbe effects were transferable into naïve recipient animals by purified CD4(+) T cells alone. Specifically, bacterial effects depended upon active immune tolerance by induction of Foxp3(+) regulatory T cells (Treg) and interleukin (Il)-10, without significantly changing the gut microbial ecology or reducing ad libitum caloric intake. Our finding that microbial targeting restored CD4(+) T cell balance and yielded significantly leaner animals regardless of their dietary 'fast food' indiscretions suggests population-based approaches for weight management and enhancing public health in industrialized societies.
超级变 变 变 (2007)

我们每天都要在电脑上进行各种应用操作,比如通过Windows桌面运行程序、编辑文档、浏览网页、聊天、听歌等,无论是哪种应用软件,都存在一个面子问题,如果每天面对的都是一成不变的界面,那生活将多么缺乏新意呀,一场换肤风暴势在必行……
Fixed-Point Quantization of 3D Convolutional Neural Networks for Energy-Efficient Action Recognition (2018)

In this paper, 3D convolutional neural networks (CNNs) are simplified to reduce the energy consumption of the action recognition process. Instead of using floating-point weights and input values, which results in a huge amount of processing energy, we introduce a systematic way to quantize all the values of 3D CNNs without degrading the recognition accuracy. Simulation results show that, compared to the baseline CNN architecture, the proposed method significantly reduces the computational complexity as well as the memory requirements.
Haplotype matching in large cohorts using the Li and Stephens model (2018)

Here I describe a new, exact algorithm ('fastLS') that implements the Li and Stephens model and achieves runtimes independent of the size of the reference cohort. Key to achieving this runtime is the use of the Burrows-Wheeler transform, allowing the algorithm to efficiently identify partial haplotype matches across a cohort. I show that the proposed data structure is very similar to, and generalizes, Durbin's positional Burrows-Wheeler transform.
Ren ( 仁) Humanist Ethics and Semiotics in the Future (2013)

Abstract The term “semiotics” is better used as a more desirable approach for promoting the modernization of global humanities. In place of a mere study of signs a new semiotics should be related to the institutionalized and institutionalizing mechanism of semantic production and communicative constitution with respect to the entire social and human sciences. For the sake of attaining this correct scientific goal semiotics should be linked with an ethics of subjectivity. Both Husserl and Wang Yangming, with different styles, provide us with the model of ethical practice that can make the semiotic scholar become spiritually capable of insisting on scientific truth against the prevailing scholarly utilitarianism caused by present-day commercialized globalization.
Effect of custom-made foot orthoses in female hallux valgus after one-year follow up (2012)

HV did not have a significantly slower evolution in participants of the experimental group compared with controls. Custom-made orthoses appear to have no effect in the evolution of mild and moderate HV during a 12 month period. Clinical relevance Subtalar joint hyperpronation plays a fundamental role in the development of hallux valgus. Conservative management typically involves the use of foot orthotics which is aimed at preventing the progress of the condition. The use of foot orthotics however should be used as a long term management strategy (beyond 12 months).
Anti-HER-2×anti-CD3 Bi-specific Antibodies Inhibit Growth of HCT-116 Colorectal Carcinoma Cells in Vitro and in Vivo (2012)

HER-2/neu might be a useful target for immunotherapy in colorectal carcinoma, anti-HER2 anti-CD3 BsAb exerting clear anti-tumor effects.
Spur reduction in bang-bang PLLs using programmable bit-stream (2011)

All-digital bang-bang phase-locked loops (PLLs) are prone to spurious output tones. In this reported work, a programmable bit-sequence is generated and used as a time-mode dithering signal. The bit-stream can be programmed to emulate the required order of a ΣΔ modulator operating in the time-domain without need for any hardware change. This method leads to a low-cost, compact, low-power and versatile phase noise-shaping scheme.
Olsenella umbonata sp. nov., a microaerotolerant anaerobic lactic acid bacterium from the sheep rumen and pig jejunum, and emended descriptions of Olsenella, Olsenella uli and Olsenella profusa (2010)

Strain A2 is an anaerobic, variably Gram-stain-positive, non-spore-forming, small and irregularly rod-shaped bacterium from the ruminal fluid of a sheep that has been described informally as a representative of 'Olsenella (basonym Atopobium) oviles'. Three phenotypically similar bacterial strains (lac15, lac16 and lac31(T)) were isolated in concert with Veillonella magna lac18(T) from the mucosal jejunum of a pig. A phylogenetic analysis based on 16S rRNA gene sequences revealed that strains A2, lac15, lac16 and lac31(T) formed a genetically coherent group (100 % interstrain sequence similarity) within the bigeneric Olsenella-Atopobium branch of the family Coriobacteriaceae, class Actinobacteria. This group was most closely related to the type strains of the two recognized Olsenella species, namely Olsenella uli (sequence similarity of 96.85 %) and Olsenella profusa (sequence similarity of 97.20 %). The sequence similarity to the type strain of Atopobium minutum, the type species of the genus Atopobium, was 92.33 %. Unlike those of O. uli and O. profusa, outgrown colonies of strains A2, lac15, lac16 and lac31(T) were opaque and greyish-white with an umbonate elevation on solid culture media. The four novel strains were characterized as being well-adapted and presumably indigenous to the gastrointestinal tract of homoeothermic vertebrates: they were mesophilic, microaerotolerant, neutrophilic and acidotolerant, bile-resistant, mucin-utilizing and markedly peptidolytic lactic acid bacteria. The results of DNA-DNA hybridizations, cellular fatty acid analysis and other differential phenotypic (physiological and biochemical) tests confirmed that strains A2, lac15, lac16 and lac31(T) represent a novel species of the genus Olsenella. On the basis of the genotypic and phenotypic results, we therefore describe Olsenella umbonata sp. nov., with lac31(T) ( = CCUG 58604(T) = DSM 22620(T) = JCM 16156(T)) as the type strain and A2 ( = CCUG 58212 = DSM 22619 = JCM 16157) as an additionally available reference strain. Also, based on our data, we propose emended descriptions of the genus Olsenella and the species Olsenella uli and Olsenella profusa.
Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I. (1994)

Although the majority of ovarian follicles undergo atresia through a mechanism involving apoptotic cell death, in vivo studies concerning the hormonal regulation of atresia have been difficult due to the presence of heterogeneous population of follicles in the ovary. In the present study, the regulation of follicle apoptosis by gonadotropins, insulin-like growth factor I (IGF-I), and IGF-binding protein 3 (IGFBP-3) was examined using a serum-free culture of preovulatory follicles. Immature rats at 26 days of age received a single dose of PMSG. Two days later, the largest preovulatory follicles were collected for in vitro culture with or without hormones. After 24 h of culture, follicular apoptotic DNA fragmentation was analyzed by autoradiography of size-fractionated DNA labeled at 3'-ends by [32P]dideoxy-ATP. A spontaneous increase in apoptotic DNA fragmentation occurred after 24 h of culture in the absence of hormones, whereas treatment with human CG (hCG) or FSH suppressed follicular apoptosis in a dose-dependent manner, with 0.1 microgram/ml causing maximal suppression by 60-62%. Cotreatment with hCG and FSH had no additional effect. Like gonadotropins, treatment with IGF-I and insulin also suppressed the spontaneous onset of apoptosis, with IGF-I being more effective than insulin. Cotreatment with IGFBP-3 and hCG dose-dependently reversed the suppressive effect of hCG on apoptosis by 42%, suggesting a mediatory role of endogenously produced IGF-I. The addition of IGFBP-3 also blocked the suppressive action of IGF-I by 49%, whereas it did not affect the suppressive action of an IGF-I agonist or insulin. Treatment with IGFBP-3 alone had no effect on apoptotic DNA fragmentation. Estrogen and progesterone production by the cultured follicles were also analyzed by RIA. Gonadotropin treatment resulted in a marked stimulation of the production of both steroid productions. In contrast, treatment with IGF-I caused a small increase in estrogen but decreased progesterone production. Although treatment with IGFBP-3 alone decreased both estrogen and progesterone production, cotreatment with IGFBP-3 and hCG resulted in a slight decrease in estrogen production but an increase in progesterone production. Furthermore, IGFBP-3 did not affect IGF-I action on steroid production. To further substantiate the hypothesis that IGFBP-3 blocks the suppressive effect of hCG on apoptosis by neutralizing endogenously produced IGF-I, solution hybridization analysis was performed, and hCG treatment was shown to increase IGF-I messenger RNA levels in cultured follicles by 1.9-fold.(ABSTRACT TRUNCATED AT 400 WORDS)