gebhart/patrepeval huggingface dataset:
CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA (2002)

Centromere protein (CENP) B boxes, recognition sequences of CENP-B, appear at regular intervals in human centromeric alpha-satellite DNA (alphoid DNA). In this study, to determine whether information carried by the primary sequence of alphoid DNA is involved in assembly of functional human centromeres, we created four kinds of synthetic repetitive sequences: modified alphoid DNA with point mutations in all CENP-B boxes, resulting in loss of all CENP-B binding activity; unmodified alphoid DNA containing functional CENP-B boxes; and nonalphoid repetitive DNA sequences with or without functional CENP-B boxes. These four synthetic repetitive DNAs were introduced into cultured human cells (HT1080), and de novo centromere assembly was assessed using the mammalian artificial chromosome (MAC) formation assay. We found that both the CENP-B box and the alphoid DNA sequence are required for de novo MAC formation and assembly of functional centromere components such as CENP-A, CENP-C, and CENP-E. Using the chromatin immunoprecipitation assay, we found that direct assembly of CENP-A and CENP-B in cells with synthetic alphoid DNA required functional CENP-B boxes. To the best of our knowledge, this is the first reported evidence of a functional molecular link between a centromere-specific DNA sequence and centromeric chromatin assembly in humans.
A novel superframe for Cognitive Radio in HR-WPAN (2009)

Progress of wireless technology makes possible people to enjoy multi-media services at home. One of the wireless technologies, IEEE 802.15.3 emerges High-Rate Wireless Personal Area Network (HR-WPAN). However, Cognitive Radio rises up one of the most talented technologies to solve the spectrum allocation problem and improving the utilization of the radio spectrum resources, since communication technology expands its province and demand for radio resource has been increasing rapidly nowadays. We propose a novel superframe structure for cognitive radio mechanism in HR-WPANs.
Development of Decreased-Gluten Wheat Enabled by Determination of the Genetic Basis of <i>lys3a</i> Barley (2019)

Celiac disease is the most common food-induced enteropathy in humans, with a prevalence of approximately 1% worldwide. It is induced by digestion-resistant, proline- and glutamine-rich seed storage proteins, collectively referred to as gluten, found in wheat (<i>Triticum aestivum</i>). Related prolamins are present in barley (<i>Hordeum vulgare</i>) and rye (<i>Secale cereale</i>). The incidence of both celiac disease and a related condition called nonceliac gluten sensitivity is increasing. This has prompted efforts to identify methods of lowering gluten in wheat, one of the most important cereal crops. Here, we used bulked segregant RNA sequencing and map-based cloning to identify the genetic lesion underlying a recessive, low-prolamin mutation (<i>lys3a</i>) in diploid barley. We confirmed the mutant identity by complementing the <i>lys3a</i> mutant with a transgenic copy of the wild-type barley gene and then used targeting-induced local lesions in genomes to identify induced single-nucleotide polymorphisms in the three homeologs of the corresponding wheat gene. Combining inactivating mutations in the three subgenomes of hexaploid bread wheat in a single wheat line lowered gliadin and low-molecular-weight glutenin accumulation by 50% to 60% and increased free and protein-bound lysine by 33%.
A social approach to security: Using social networks to help detect malicious web content (2010)

In the midst of a social networking revolution, social media has become the new vehicle for effective business marketing and transactions. As social aspects to the Internet continue to expand in both quantity and scope, so has the security threat towards enterprise networks and systems. Many social networking users also become main targets of spams, phishing, stalking, and other malware attacks that exploit the trust among social network “friends”. This paper presents a comprehensive method combining traditional security heuristics with social networking data to aid in the detection of malicious web content as it propagates through the user's network. A Facebook application is implemented to automatically evaluate and detect malicious link content. The results of testing this application against known phishing and malware sites with real-world user profiles have shown encouraging results.
Role of Proteolytic Activation of Protein Kinase Cδ in Oxidative Stress-Induced Apoptosis (2003)

Protein kinase Cdelta (PKCdelta), a member of the novel PKC family, is emerging as a redox-sensitive kinase in various cell types. Oxidative stress activates the PKCdelta kinase by translocation, tyrosine phosphorylation, or proteolysis. During proteolysis, caspase-3 cleaves the native PKCdelta (72-74 kDa) into 41-kDa catalytically active and 38-kDa regulatory fragments to persistently activate the kinase. The proteolytic activation of PKCdelta plays a key role in promoting apoptotic cell death in various cell types, including neuronal cells. Attenuation of PKCdelta proteolytic activation by antioxidants suggests that the cellular redox status can influence activation of the proapoptotic kinase. PKCdelta may also amplify apoptotic signaling via positive feedback activation of the caspase cascade. Thus, the dual role of PKCdelta as a mediator and amplifier of apoptosis may be important in the pathogenesis of major neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, and Huntington disease.
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin (2004)

The fat-derived hormone leptin regulates energy balance in part by modulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate nucleus. To study the intrinsic activity of these neurons and their responses to leptin, we generated mice that express distinct green fluorescent proteins in these two neuronal types. Leptin-deficient (ob/ob) mice differed from wild-type mice in the numbers of excitatory and inhibitory synapses and postsynaptic currents onto neuropeptide Y and proopiomelanocortin neurons. When leptin was delivered systemically to ob/ob mice, the synaptic density rapidly normalized, an effect detectable within 6 hours, several hours before leptin's effect on food intake. These data suggest that leptin-mediated plasticity in the ob/ob hypothalamus may underlie some of the hormone's behavioral effects.
Parasoziale Interaktion und Identität im elektronisch mediatisierten Kommunikationsraum (1996)

Die Kommunikationswissenschaft ist im Umbruch, weil sich ihr Gegenstands- und Anwendungsbereich durch die Dynamik der gesellschaftlichen, der ökonomischen und der technischen Entwicklungen verändert. Der Umgang mit „intelligenten“ Computerprogrammen beispielsweise ist eine Form von Interaktion bzw. Kommunikation, die vor zwei Jahrzehnten nur wenigen Spezialisten vorstellbar war, aber heute für viele Menschen zum Alltag gehört. Kommunikationswissenschaftlich gesehen ist das Internet eine Komponente eines neuen, eines elektronisch vermittelten Kommunikationsraums (Krotz, 1995b), in dem mindestens drei verschiedene Interaktionsformen zugleich stattfinden können: erstens interpersonale, zweitens auf Computerprogramme und drittens auf standardisierte Kommunikate wie Bilder, Filme, Radiosendungen oder Texte gerichtete Kommunikation. In einer solchen Situation, in der die Wissenschaft neuer Konzepte bedarf, lohnt es, die alten Überlegungen noch einmal nachzuvollziehen und zu untersuchen, inwieweit sie zum Verständnis auch neuer Entwicklungen beitragen können.
Optical prefiltering in subcarrier systems (1992)

A novel approach to demultiplexing in subcarrier optical systems is described. The technique of optical prefiltering microwave subcarriers from an optical carrier, enabling direct detection of baseband signals, is proposed. The technique is experimentally verified by demultiplexing two 10 M/s channels.
The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation (2004)

Azathioprine metabolism is influenced by activity of the enzyme thiopurine S-methyltransferase (TPMT), which varies markedly between individuals. In this study we examined the influence of TPMT gene polymorphisms on azathioprine dose 1 year after renal transplantation. TPMT coding and promoter genotypes were determined using PCR-based assays. Azathioprine dose, white cell count, and intercurrent events throughout the first year after renal transplantation were ascertained from contemporaneous clinical notes. All patients analysed ( n=172) received an initial azathioprine dose of 1.5 mg/kg per day. Twelve individuals with one variant TPMT coding allele were detected (*3A n=11, *3C n=1). Of these, 58% required azathioprine dose reduction because of leucopenia, compared to only 30% of homozygous wild-type patients ( P=0.04). A significant correlation between the presence of >/=11 variable number tandem repeats (VNTRs) in the TPMT promoter and reduction in azathioprine dose was also identified ( P=0.001). We concluded that when azathioprine is administered at an initial dose of 1.5 mg/kg per day, both coding and promoter TPMT polymorphisms influence the dose tolerated.
A Multiple Sensor Machine Vision System for Automatic Hardwood Feature Detection (1993)

A multiple sensor machine vision prototype is being developed to scan full size hardwood lumber at industrial speeds for automatically detecting features such as knots, holes, wane, stain, splits, checks, and color. The prototype integrates a multiple sensor imaging system, a materials handling system, a computer system, and application software. The prototype provides a unique general purpose research facility so that a variety of different industry-scale problems can be addressed in both primary and secondary hardwood manufacturing. BACKGROUND There are three main categories into which features on hardwood lumber may be classified. These are: 1) visual surface features (e.g. knots holes, splits, decay, color, grain orientation), 2) board geometry features (e.g., warp, crook, wane, thickness variations, voids), and 3) internal features (e.g., honeycomb, voids, decay). Surface geometric, and internal features have been categorized in this way because they often require different detection methods that depend on where they appear. Most of these features are treated as defects to be removed in the manufacturing process. Current hardwood mill operations examine lumber manually to locate and identify these types of defects. 1The authors are, respectively, Assistant Professor, Dept. of Wood Science and Forest Products, Virginia Tech, Blacksburg, VA 24061-0323; Associate Professor, Spatial Data Analysis Laboratory, Virginia Tech, Blacksburg, VA 24061-0111; Research Forest Products Technologist and Project Leader, U.S. Forest Service, Brooks Forest Products Center, Virginia Tech, Blacksburg, VA 24061-0503; Project Leader, U.S. Forest Semite, Forest Sciences Laboratory, Princeton, WV 24740. The authors wish to acknowledge Virginia’s Center for Innovative Technology and the U.S. Forest Service for partial support of this project.
Improving the security of Android inter-component communication (2013)

Abstract—In the Android operating system, each application consists of a set of components that communicate with each other via messages called Intents. The current implementation of Intent handling is such that developers can inadvertently write insecure code that allows malicious applications to intercept or inject Intents to steal sensitive information or induce undesired behavior. We prevented these exploits by modifying Android’s Intent handling behavior to err on the side of safety except where the developer seems to explicitly specify otherwise. Additonally, we confirmed the pervasiveness of Intent vulnerabilities by analyzing the 497 most popular free applications in Android’s official application market, and proved the effectiveness of our modifications by manually verifying that they closed a substantial number of the security holes we identified. I.
An all-in-one solution to geometric and photometric calibration (2006)

We propose a fully automated approach to calibrating multiple cameras whose fields of view may not all overlap. Our technique only requires waving an arbitrary textured planar pattern in front of the cameras, which is the only manual intervention that is required. The pattern is then automatically detected in the frames where it is visible and used to simultaneously recover geometric and photometric camera calibration parameters. In other words, even a novice user can use our system to extract all the information required to add virtual 3D objects into the scene and light them convincingly. This makes it ideal for Augmented Reality applications and we distribute the code under a GPL license.
Composite Film Based on Pulping Industry Waste and Chitosan for Food Packaging (2018)

Wood auto-hydrolysates (WAH) are obtained in the pulping process by the hydrothermal extraction, which contains lots of hemicelluloses and slight lignin. WAH and chitosan (CS) were introduced into this study to construct WAH-based films by the casting method. The FT-IR results revealed the crosslinking interaction between WAH and CS due to the Millard reaction. The morphology, transmittance, thermal properties and mechanical properties of composite WAH/CS films were investigated. As the results showed, the tensile strength, light transmittances and thermal stability of the WAH-based composite films increased with the increment of WAH/CS content ratio. In addition, the results of oxygen transfer rate (OTR) and water vapor permeability (WVP) suggested that the OTR and WVP values of the films decreased due to the addition of CS. The maximum value of tensile strengths of the composite films achieved 71.2 MPa and the OTR of the films was low as 0.16 cm³·μm·m<sup>-2</sup>·24 h<sup>-1</sup>·kPa<sup>-1</sup>, these properties are better than those of other hemicelluloses composite films. These results suggested that the barrier composite films based on WAH and CS will become attractive in the food packaging application for great mechanical properties, good transmittance and low oxygen transfer rate.
A Background Modeling Method with Simple Operations for 3D Video (2007)

This paper proposes a novel 3D background modeling method that only needs simple manual operations. For generating a background 3D model, the background area of a 3D scene is divided into a "ground region" and a "distant region." The 3D model of the distant region is represented by vertical rectangular planes with video texture. The ground region is modeled as a simple horizontal plane. These two regions are specified by a few points given manually in each image of multiple cameras. After the points are given by an operator, operation of the 3D background modeling is conducted based on the knowledge of camera poses and the target scene. We generated 3D videos of a background by using multiple 2D videos recorded at the Japan National Kasumigaoka Stadium and the Gymnasium of the Japan Institute of Sports Science to show the validity of our method.
Topical Treatment of Ulcerative Colitis using Enemas Containing 5-Aminosalicylic Acid and Beclomethasone Dipropionate (1990)

5-Aminosalicylic acid (5-ASA) enemas constitute a first-line therapy for patients with mild to moderate attacks of ulcerative colitis. To date, based on the results of different studies, 5-ASA enemas appear to be satisfactory in at least two-thirds of patients treated. Beclomethasone is one of the new corticosteroids which appear to have minimal systemic effects. The authors have assessed the efficacy of a four week course of 3 mg beclomethasone enemas compared to 2 g 5-ASA enemas in patients with ulcerative colitis. Preliminary analysis would suggest that both therapies are effective in more than 50% of cases.
Enantioselective synthesis and absolute configuration of (-)-.alpha.-kainic acid (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective synthesis and absolute configuration of (-)-.alpha.-kainic acidWolfgang Oppolzer and Klaus ThirringCite this: J. Am. Chem. Soc. 1982, 104, 18, 4978–4979Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/ja00382a054https://doi.org/10.1021/ja00382a054research-articleACS PublicationsRequest reuse permissionsArticle Views1153Altmetric-Citations158LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neutrophil enzymes in urine for the detection of urethral infection in men. (1995)

Further studies of neutrophil elastase in the pathogenesis, diagnosis and treatment of urethritis are indicated.
Micronized Purified Flavonoid Fraction (MPFF)*: A Review of its Pharmacological Effects, Therapeutic Efficacy and Benefits in the Management of Chronic Venous Insufficiency (2005)

Initially, the progression of chronic venous insufficiency is related to venous hypertension. The earliest complaints or symptoms, as well as vessel wall deterioration, valve restructuring, and, eventually, varicose veins, result not only from elevation of pressure, but also from a cascade of biochemical events related to both the macro- and the microcirculation. Thickening and remodelling of the venous wall are influenced by two parameters: abnormal shear stress and hypoxia that activate the endothelium first at the level of valve cusps and then in large veins. Hypoxia leads to activation of the endothelium and leukocyte accumulation. By inhibiting endothelial activation, micronized purified flavonoid fraction (MPFF) (Daflon 500 mg), an edema-protective agent, can prevent the inflammatory cascade resulting from the leukocyte-endothelium interaction. This subsequently delays the appearance of reflux and inhibits the initiation of the vicious circle ending in enhanced venous pressure. This is how Daflon 500 mg relieves patients from symptoms and edema and possibly also prevents the appearance of varicose veins. Rheological disturbances also play a major role in the appearance of these disorders. Furthermore, venous hypertension provokes leakage from the vessels and capillaries exhibiting increased permeability, leading to increases in hydrostatic load, and overloading of the lymphatic network, which subsequently results fluid exudation causing edema. Microcirculatory dysfunction leads to capillary damage, skin changes and venous leg ulcers. The clinical efficacy of Daflon 500 mg in venous leg ulcers has been demonstrated by several randomised controlled studies, in which the rate of ulcer healing was significantly shortened. An explanation for the ability to speed ulcer healing comes from the protection Daflon 500 mg exerts on the microcirculation.
Probing the structure and stability of the tumor-localizing derivative of hematoporphyrin by reductive cleavage with LiAlH4. (1987)

A procedure involving the use of the reducing agent lithium aluminum hydride (LiAlH4) has been designed to explore the nature of the oligomer linkages in the tumor-localizing component of hematoporphyrin derivative (HPD). High-performance liquid chromatography and fast-atom bombardment mass spectrometry were used to determine the reduction products. The results are consistent with a structure wherein ester linkages join hematoporphyrin molecules. The presence of minor amounts of ether-linked porphyrins was confirmed, and their origin was determined through the application of the chemical reduction process to HPD. An increased proportion of ether-linked porphyrins was detected during storage of HPD at room temperature or above. The commercial product Photofrin II, presumably an HPD preparation enriched in the dimer/oligomer fraction, was found to contain approximately 50% ether linkages. This product therefore differs from the corresponding fraction of freshly prepared HPD.
LEDs for solid state lighting and other emerging applications: status, trends, and challenges (2005)

LEDs have been commercially available since the 1960's, but in recent years there have been remarkable improvements in performance. These technology developments have enabled the use of LEDs in a variety of colored and white lighting applications. Colored LEDs have already become the technology of choice for traffic signals, much of interior and exterior vehicle lighting, signage of various types often as a replacement for neon, and other areas. LEDs are expected to become the dominant technology for most colored lighting applications. LEDs are beginning to penetrate white lighting markets such as flashlights and localized task lighting. With further improvement LEDs have the potential to become an important technology for large area general illumination. White LED products already have performance of over 30 lumens/watt which is nearly 3x better than incandescents. White LEDs with outputs of more than 100 lumens are already available commercially, and higher power devices can be expected in the near future. LEDs can be used as point sources, or can be used with light guides of various types to provide distributed illumination. Developments that will need to occur for LEDs to be viable for large area general illumination are discussed.
Very-high-speed back-illuminated InGaAs/InP PIN punch-through photodiodes (1981)

Long-wavelength back-illuminated PIN photodiodes capable of detecting optical signals at multigigabit modulation rates have been fabricated and tested in a stripline circuit. A transit-time-limited response time of about 30 ps has been realised in a 25 μm-diameter diode.
Martian magnetic morphology: Contributions from the solar wind and crust (2003)

Mars Global Surveyor (MGS) Magnetometer (MAG) data provide constraints on magnetic morphology at Mars, including the relative importance of the solar wind and of crustal magnetic sources. We analyze MAG data to characterize the upstream interplanetary magnetic field (IMF) and confirm trends in the magnetic field expected from the solar wind interaction with a planetary atmosphere, including increases at the shock and magnetic pile‐up boundary (MPB), postshock turbulence, and field line draping around the Martian obstacle. Crustal magnetic sources locally modify the solar wind interaction, adding variability to the Martian magnetic environment that depends on planetary rotation. We identify trends in the vector magnetic field with respect to altitude, solar zenith angle, and planetary location. Crustal sources influence the magnetic field to different altitudes above different regions, and the influence of the strongest source extends to 1300–1400 km. The draped IMF partially controls the field topology above crustal sources, and crustal magnetic field lines reconnect to this field in a systematic fashion that depends upon Mars' geography, IMF strength, and IMF orientation.