gebhart/patrepeval huggingface dataset:
Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG (1999)

It is widely accepted that immunoglobulin (Ig)E triggers immediate hypersensitivity responses by activating a cognate high-affinity receptor, FcepsilonRI, leading to mast cell degranulation with release of vasoactive and proinflammatory mediators. This apparent specificity, however, is complicated by the ability of IgE to bind with low affinity to Fc receptors for IgG, FcgammaRII and III. We have addressed the in vivo significance of this interaction by studying IgE-mediated passive systemic anaphylaxis in FcgammaR-deficient mice. Mice deficient in the inhibitory receptor for IgG, FcgammaRIIB, display enhanced IgE-mediated anaphylactic responses, whereas mice deficient in an IgG activation receptor, FcgammaRIII, display a corresponding attenuation of IgE-mediated responses. Thus, in addition to modulating IgG-triggered hypersensitivity responses, FcgammaRII and III on mast cells are potent regulators of IgE-mediated responses and reveal the existence of a regulatory pathway for IgE triggering of effector cells through IgG Fc receptors that could contribute to the etiology of the atopic response.
Fine-scale impervious surface extraction by fusing high resolution remote sensing images and vehicle digital measurable images (2016)

Impervious surface area (ISA) as the indicator of urbanization has a significance for urban ecological environment evaluation. Impervious surface extracting methods based on high-resolution remote sensing imagery can extract ISA in a fine-scale. However, a series of consequent problems cannot be ignored, such as shadows from tall building and canopies. In order to solve the shadow problem, high-resolution remote sensing image from Wuhan city is divided into three classes which are shadows, impervious surface and pervious. Due to the shadow and vegetation area along the street, the vehicle mounted digital measurable images are introduced to obtain fine-scale impervious surface information. D-S theory of evidence was employed to detect the shadow area according to spectral information. Then the impervious surface was extracted by fusing VHR remote sensing image and vehicle digital measurable images. The results showed that the proposed method was capable to provide the extraction of fine-scale impervious surface.
Non-binary WOM-codes for multilevel flash memories (2011)

A Write-Once Memory (WOM)-code is a coding scheme that allows information to be written in a memory block multiple times, but in a way that the stored values are not decreased across writes. This work studies non-binary WOM-codes with applications to flash memory. We present two constructions of non-binary WOM-codes that leverage existing high sum-rate WOM-codes defined over smaller alphabets. In many instances, these constructions provide the highest known sum-rates of the non-binary WOM-codes. In addition, we introduce a new class of codes, called level distance WOM-codes, which mitigate the difficulty of programming a flash memory cell by eliminating all small-magnitude level increases. We show how to construct such codes and state an upper bound on their sum-rate.
Is D-dimer a Reliable Serum Marker for Shoulder Periprosthetic Joint Infection? (2021)

Level III, diagnostic study.
2-<i>O</i>-(β-<scp>l</scp>-Arabinopyranosyl)-<i>myo</i>-inositol as a Main Constituent of Tea (<i>Camellia sinensis</i>) (1989)

A new main tea constituent, 2-O-(β-l-arabinopyranosyl)-myo-inositol (1, ca. 0.8 % of a Japanese green tea) was characterized by 13C-NMR spectroscopy. The inositol glycoside (1) has been found not only in all the tea extracts so far examined but also in the homogenate of Camellia sinensis var. sinensis (“Yabukita cultivar”), suggesting its physiological importance in carbohydrate metabolism in the tea plant.
A novel approach for flexible and consistent ADL-driven ASIP design (2004)

Architecture description languages (ADL) have been established to aid the design of application-specific instruction-set processors (ASIP). Their main contribution is the automatic generation of a software toolkit, including C compiler, assembler, linker, and instruction-set simulator. Hence, the challenge in the design of such ADLs is to unambiguously capture the architectural information required for the toolkit generation in a single model. This is particularly difficult for C compiler and simulator, as both require information about the instructions' semantics, however, while the C compiler needs to know what an instructions does, the simulator needs to know how. Existing ADLs solve this problem by either introducing redundancy or by limiting the language's flexibility.This paper presents a novel, mixed-level approach for ADL-based instruction-set description, which offers maximum flexibility while preventing from inconsistencies. Moreover, it enables capturing instruction- and cycle-accurate descriptions in a single model. The feasibility and design efficiency of our approach is demonstrated with a number of contemporary, real-world processor architectures.
Data archiving in 1x-nm NAND flash memories: Enabling long-term storage using rank modulation and scrubbing (2016)

The challenge of using inexpensive and high-density NAND flash for archival storage was posed recently for reducing data center costs. However, such flash memory is becoming more susceptible to noise, and its reliability issues has become the major concern for its adoption by long-term storage systems. This paper studies the system-level reliability of archival storage that uses 1x-nm NAND flash memory. We analyze retention error behavior, and show that 1x-nm MLC and TLC flash do not immediately qualify for long-term storage. We then implement the rank modulation (RM) scheme and memory scrubbing (MS) for retention period (RP) enhancement. The RM scheme provides a new data representation using the relative order of cell voltages, which provides higher reliability against uniform asymmetric threshold voltage shift due to charge leakage. Results show that the new representation reduces raw bit error rate (RBER) by 45% on average, and using RM and MS together provides up to 196, 171, 146 and 121 years of RPs for blocks with 0, 25, 50 and 75 program/erase cycles, respectively.
Compression Of Data In Imaging Radar Polarimetry (1989)

Algorithms developed to reduce number of radar polarimetric data processed to synthesize image of arbitrary combination of transmitting and receiving polarizations. Brings image-processing requirements within computing capabilities of typical users, without degrading images excessively. In scattering-matrix approach to reduction of image data, four adjacent picture elements combined into one by synthesizing new scattering matrix from scattering matrices of four elements. In phase-matrix approach, phase matrices generated from scattering matrices of four adjacent picture elements, and four phase matrices added to combine four picture elements into one.
Molecular biology of the angiotensin I converting enzyme: II. Structure-function. Gene polymorphism and clinical implications (1993)

Soubrier, Florent; Wei, Lei; Hubert, Christine; Clauser, Eric; Alhenc-Gelas, Francois; Corvol, Pierre Author Information
A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation (2012)

Somatic cells can be reprogrammed to form embryonic stem cell-like induced pluripotent stem cells (iPSCs), but the process suffers from low efficiency and the underlying molecular mechanisms that control reprogramming remain poorly understood. Here we perform an inhibitor screen to identify kinases that enhance, or present a barrier to, reprogramming. In particular, inhibitors of p38, inositol trisphosphate 3-kinase, and Aurora A kinase potently enhance iPSC generation, and iPSCs derived from inhibitor-treated somatic cells are capable of reaching a fully reprogrammed state. Knockdown of target kinases by short interfering RNAs confirms that they function as barrier genes. We show that Aurora A kinase, which functions in centrosome activity and spindle assembly, is highly induced during reprogramming and inhibits Akt-mediated inactivation of GSK3β, resulting in compromised reprogramming efficiency. Together, our results not only identify new compounds that enhance iPSC generation but also shed new light on the function of Aurora A kinase in the reprogramming process.
Polyaniline: Synthesis and properties of pernigraniline base (1991)

The most highly oxidized polyaniline, in the form of pernigraniline base, can be synthesized as an analytically and oxidatively pure solid (powder or large free-standing films) by the controlled oxidation of emeraldine base by m-chloroperbenzoic acid or directly from aniline by oxidative polymerization with (NH4)2S2O8. In the first method, the emeraldine oxidation state is converted directly to the pernigraniline oxidation state without passing through any intermediate discrete oxidation state at the molecular level. Treatment of perigraniline base with aqueous HCl results not in a protonated form of pernigraniline but in reductive ring chlorination to give the emeraldine oxidation state.
Development of Broadband Underwater Radio Communication for Application in Unmanned Underwater Vehicles (2020)

This paper presents several novel designs of underwater portable radio antennas operating in the 2 MHz, 50 MHz and 2.4 GHz bands and efficient for launching surface electromagnetic waves at the seawater/air interface. The antenna operation is enabled by an impedance matching antenna enclosure, which is filled with de-ionized water. Enhanced coupling to surface electromagnetic waves is based on the field enhancement at the antenna tip. These design features allow us to reduce antenna dimensions and improve the coupling of electromagnetic energy to the surrounding saltwater medium. Since surface wave propagation length far exceeds the skin depth of conventional radio waves at the same frequency, this technique is useful for broadband underwater wireless communication over distances, which far exceed the skin depth in seawater. We conclude that the developed broadband underwater radio communication technique will be useful in networking of unmanned underwater vehicles.
Amplified Photodegradation of Cell‐Laden Hydrogels via an Addition–Fragmentation Chain Transfer Reaction (2017)

Hydrogels crosslinked by allyl-sulfide-containing molecules are presented. By exposure to light in the presence of a photoinitiator and a free monofunctional thiol, photodegradation is achieved. Both the gelation and degradation are cytocompatible and allow for cell encapsulation and subsequent release. The photodegradation kinetics and depths attainable are superior to those of traditional cell-laden photodegradable hydrogels.
Cerium Chloride−methanol Adduct Crystals, CeCl<sub>3</sub>(CH<sub>3</sub>OH)<sub>4</sub>: Preparation, Crystallography, And Scintillation Properties (2008)

A new methanol adduct of cerium trichloride of composition CeCl3(CH3OH)4 was crystallized from a solution growth in methanol. Large single crystals (more than several cubic centimeters) have been grown in controlled temperature baths. The molecular adduct of composition Ce2Cl6(CH3OH)8 is determined from X-ray crystal structure analysis, and this molecule undoubtedly persists in solution as well. Motivations for studying these compounds are their promising unique scintillation properties for radiation detection applications and the model structural systems they provide for the realization of new low-dimensional quantum magnets. This material apparently represents the first example of a metal-organic scintillator that is applicable to X-ray, γ-ray, and neutron detection.
Bovine herpesvirus‐1 vaccines (1993)

Vaccination has been important in controlling a wide variety of viral and bacterial infections of man and animals. Vaccines to herpesvirus infection of cattle are no exception. The present review describes the different types of conventional vaccines that have been used to date and furthermore describes the novel approaches which are presently being implemented to develop more effective vaccines. These include subunit vaccines as well as genetically engineered modified live deletion mutants. Both these novel vaccine approaches appear to be more efficacious than conventional vaccines. Furthermore, these vaccines provide an additional dimension for control and eradication of infection by providing an opportunity to develop companion diagnostic tests to differentiate infected animals from vaccinated animals. This review summarizes these developments as well as present knowledge regarding the important host defence mechanisms required for preventing infection and aiding recovery from infection.
Purified Recombinant TAT-Homeobox B4 Expands CD34 <sup>+</sup> Umbilical Cord Blood and Peripheral Blood Progenitor Cells <i>Ex Vivo</i> (2009)

Hematopoietic stem cells (HSCs) are commonly used in clinical transplantation protocols to treat a variety of diseases. However, efficient transplantation requires a substantial amount of HSCs from different sources and may require expansion. Therefore, effective expansion of HSCs remains a technical hurdle blocking the development of advanced cell therapies. The product of the human homeobox B4 (HOXB4) gene was recently demonstrated to effectively expand HSCs from umbilical cord blood (UCB) or bone marrow in either a retroviral or recombinant protein form. Our study purified TAT-HOXB4 proteins and demonstrated their ability to expand UCB and peripheral blood (PB) progenitor cells. The results showed that the TAT-HOXB4 gene product expanded the CD34(+) progenitor cells from UCB and PB by approximately 7.5-fold. The results from a semisolid cloning assay, a human long-term culture-initiating cell assay, and a nonobese diabetic-severe combined immunodeficiency mice repopulating assay showed that TAT-HOXB4 expanded hematopoietic progenitor cells while retaining their repopulating capacity and multipotency. TAT-HOXB4 protein also expanded engrafted stem cells that were previously expanded in a secondary transplantation assay. The results demonstrated the feasibility of using TAT-HOXB4 to expand UCB and PB progenitor cells, which are readily available to treat different hematological malignancies and nonhematological diseases.
Driving mutually coupled gradient array coils in magnetic resonance imaging (2019)

Bench-top and MRI experiments demonstrate the feasibility of the proposed circuit model and analytical formulas to drive the mutually coupled gradient coils.
Affinity-matured recombinant immunotoxin targeting gangliosides 3′-isoLM1 and 3′,6'-isoLD1 on malignant gliomas (2013)

About 60 percent of glioblastomas highly express the gangliosides 3'-isoLM1 and 3',6'-isoLD1 on the cell surface, providing ideal targets for brain tumor immunotherapy. A novel recombinant immunotoxin, DmAb14m-(scFv)-PE38KDEL (DmAb14m-IT), specific for the gangliosides 3'-isoLM1 and 3',6'-isoLD1, was constructed with improved affinity and increased cytotoxicity for immunotherapeutic targeting of glioblastoma. We isolated an scFv parental clone from a previously established murine hybridoma, DmAb14, that is specific to both 3'-isoLM1 and 3',6'-isoLD1. We then performed in vitro affinity maturation by CDR hotspot random mutagenesis. The binding affinity and specificity of affinity-matured DmAb14m-IT were measured by surface-plasmon resonance, flow cytometry, and immunohistochemical analysis. In vitro cytotoxicity of DmAb14m-IT was measured by protein synthesis inhibition and cell death assays in human cell lines expressing gangliosides 3'-isoLM1 and 3',6'-isoLD1 (D54MG and D336MG) and xenograft-derived cells (D2224MG). As a result, the KD of DmAb14m-IT for gangliosides 3'-isoLM1 and 3',6'-isoLD1 was 2.6 × 10(-9)M. Also, DmAb14m-IT showed a significantly higher internalization rate in cells expressing 3'-isoLM1 and 3',6'-isoLD1. The DmAb14m-IT IC 50 was 80 ng/mL (1194 pM) on the D54MG cell line, 5 ng/ml (75 pM) on the D336MG cell line, and 0.5 ng/ml (7.5 pM) on the D2224MG xenograft-derived cells. There was no cytotoxicity on ganglioside-negative HEK293 cells. Immunohistochemical analysis confirmed the specific apparent affinity of DmAb14m-IT with 3'-isoLM1 and 3',6'-isoLD1. In conclusion, DmAb14m-IT showed specific binding affinity, a significantly high internalization rate, and selective cytotoxicity on glioma cell lines and xenograft-derived cells expressing 3'-isoLM1 and 3',6'-isoLD1, thereby displaying robust therapeutic potential for testing the antitumor efficacy of DmAb14m-IT at the preclinical level and eventually in the clinical setting.
Synthesis and Structure—Activity Relationships of Piperidine‐Based Melanin‐Concentrating Hormone Receptor 1 Antagonists. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Analytic Word Recognition Algorithm Using a Posteriori Probability (2007)

Word recognition algorithms are classified into two major groups. One is an "analytic" approach of recognizing individual characters, while the other is a "holistic" approach dealing with an entire word image. In the former approach, matching scores used to be calculated using heuristic functions, such as an average of confidence values on character recognition. In some non-heuristic studies, a stochastic evaluation function is employed, which is a ratio between an "a posteriori" probability and an "a priori" probability ("a posteriori" probability ratio). In this research, a new evaluation function is proposed, which is an improvement of "a posteriori" probability ratio. A result of an experiment using real images shows 9.1% improvement on handwritten word recognition.
Retina imaging in vivo with the adaptive optics confocal scanning laser ophthalmoscope (2009)

An adaptive optics confocal scanning laser ophthalmoscope (AOSLO) for retina imaging is devoloped in this paper. By using a wavefront sensor (Shack-Hartmann wavefront sensor with 11×11 lenslet array) to measure aberrations of human eye and a wavefront compensator (37-channel PZT deformable mirror) to correct for the aberrations, the AOSLO system can acquire near diffraction-limited image of human retina over the whole field of view (1×1 degree ~ 3×3 degree). The imaging frequency is 30Hz, which provides a real-time observation of human cone mosaic <i>in vivo</i>. The system has potential application in early disease diagnose and vision research.
Wi-Fi neighborcast (2008)

Several applications require physically nearby Wi-Fi clients to communicate with each other. In this paper, we present a new group communication paradigm, called Neighborcast, that forms a multicast group among all nearby clients, even when they are on different frequency channels or associated to different Access Points. We describe three ways in which neighborcast can be implemented, and present three applications that will benefit from this new group communication paradigm.
Red Blood Cell Hitchhiking: A Novel Approach for Vascular Delivery of Nanocarriers (2021)

Red blood cell (RBC) hitchhiking is a method of drug delivery that can increase drug concentration in target organs by orders of magnitude. In RBC hitchhiking, drug-loaded nanoparticles (NPs) are adsorbed onto red blood cells and then injected intravascularly, which causes the NPs to transfer to cells of the capillaries in the downstream organ. RBC hitchhiking has been demonstrated in multiple species and multiple organs. For example, RBC-hitchhiking NPs localized at unprecedented levels in the brain when using intra-arterial catheters, such as those in place immediately after mechanical thrombectomy for acute ischemic stroke. RBC hitchhiking has been successfully employed in numerous preclinical models of disease, ranging from pulmonary embolism to cancer metastasis. In addition to summarizing the versatility of RBC hitchhiking, we also describe studies into the surprisingly complex mechanisms of RBC hitchhiking as well as outline future studies to further improve RBC hitchhiking's clinical utility.
Adaptive optics ophthalmologic systems using dual deformable mirrors (2007)

Adaptive Optics (AO) have been increasingly combined with a variety of ophthalmic instruments over the last decade to provide cellular-level, in-vivo images of the eye. The use of MEMS deformable mirrors in these instruments has recently been demonstrated to reduce system size and cost while improving performance. However, currently available MEMS mirrors lack the required range of motion for correcting large ocular aberrations, such as defocus and astigmatism. In order to address this problem, we have developed an AO system architecture that uses two deformable mirrors, in a woofer / tweeter arrangement, with a bimorph mirror as the woofer and a MEMS mirror as the tweeter. This setup provides several advantages, including extended aberration correction range, due to the large stroke of the bimorph mirror, high order aberration correction using the MEMS mirror, and additionally, the ability to 'focus' through the retina. This AO system architecture is currently being used in four instruments, including an Optical Coherence Tomography (OCT) system and a retinal flood-illuminated imaging system at the UC Davis Medical Center, a Scanning Laser Ophthalmoscope (SLO) at the Doheny Eye Institute, and an OCT system at Indiana University. The design, operation and evaluation of this type of AO system architecture will be presented.
Intrinsic Temperature Compensation of Interferometric and Polarimetric Fiber-Optic Current Sensors (2014)

We theoretically and experimentally demonstrate a method to achieve insensitivity to temperature to within <±0.1% from −40 to 85°C for fiber-optic current sensors with dynamic and static phase biasing and different types of sensing fiber.
A Practical Synthesis of Azetidine (1988)

Abstract A process for the preparation of kilogram quantities of distilled azetidine is described.
Reduction of surface recombination current in GaAs <i>p</i>-<i>n</i> junctions (1979)

Planar Zn-diffused GaAs p-n junctions have been prepared with a 2000-Å surface layer of high-resistivity O-doped Al0.5Ga0.5As. This surface layer significantly reduces the surface recombination current and permits the bulk diffusion current, I∝exp(qV/kT), to dominate at current densities as low as ∼5×10−3 A/cm2.
Nanopore sensors for DNA analysis (2012)

Solid-state nanopore sensors are promising devices for single DNA molecule detection and sequencing. This paper presents a review of our work on solid-state nanopores performed over the last decade. In particular, here we discuss atomic-layer-deposited (ALD)-based, graphene-based, and functionalized solid state nanopores.
Separation of tocopherol homologues by selective deacylation and chromatography (1984)

Abstract Isolation of tocopherol homologues can be accomplished by selective deacylation of tocopheryl esters followed by chromatographic separation of the esters from the free tocopherols.
A Quantum Key Distribution Protocol with Selecting Announced States, Robust against Photon Number Splitting Attacks (2006)

We propose a new class of quantum key distribution protocol, that ended up to be robust against photon number splitting attacks in the weak laser pulse implementations. This protocol comprises of BB84 protocol and SARG protocol, especially in aspects of controlling classical sifting procedures of two protocols. The protocol is more secure than both of BB84 protocol and SARG protocol, and the ultimate limit of robustness in the proposed protocol expands as well than both of them.