gebhart/patrepeval huggingface dataset:
Envelope structure of four gliding filamentous cyanobacteria (1995)

The cell walls of four gliding filamentous Oscillatoriaceae species comprising three different genera were studied by freeze substitution, freeze fracturing, and negative staining. In all species, the multilayered gram-negative cell wall is covered with a complex external double layer. The first layer is a tetragonal crystalline S-layer anchored on the outer membrane. The second array is formed by parallel, helically arranged surface fibrils with diameters of 8 to 12 nm. These fibrils have a serrated appearance in cross sections. In all cases, the orientation of the surface fibrils correlates with the sense of revolution of the filaments during gliding, i.e., clockwise in both Phormidium strains and counterclockwise in Oscillatoria princeps and Lyngbya aeruginosa. The lack of longitudinal corrugations or contractions of the surface fibrils and the identical appearances of motile and nonmotile filaments suggest that this structure plays a passive screw thread role in gliding. It is hypothesized that the necessary propulsive force is generated by shear forces between the surface fibrils and the continuing flow of secreted extracellular slime. Furthermore, the so-called junctional pores seem to be the extrusion sites of the slime. In motile cells, these pores exhibit a different staining behavior than that seen in nonmotile ones. In the former, the channels of the pores are filled with electron-dense material, whereas in the latter, the channels appear comparatively empty, highly contrasting the peptidoglycan. Finally, the presence of regular surface structures in other gliding prokaryotes is considered an indication that comparable structures are general features of the cell walls of gliding microbes.
Modulation of cardiac Na<sup>+</sup>current by gadolinium, a blocker of stretch-induced arrhythmias (2001)

Gd(3+) blocks stretch-activated channels and suppresses stretch-induced arrhythmias. We used whole cell voltage clamp to examine whether effects on Na(+) channels might contribute to the antiarrhythmic efficacy of Gd(3+). Gd(3+) inhibited Na(+) current (I(Na)) in rabbit ventricle (IC(50) = 48 microM at -35 mV, holding potential -120 mV), and block increased at more negative test potentials. Gd(3+) made the threshold for I(Na) more positive and reduced the maximum conductance. Gd(3+) (50 microM) shifted the midpoints for activation and inactivation of I(Na) 7.9 and 5.7 mV positive but did not alter the slope factor for either relationship. Activation and inactivation kinetics were slowed in a manner that could not be explained solely by altered surface potential. Paradoxically, Gd(3+) increased I(Na) under certain conditions. With membrane potential held at -75 mV, Gd(3+) still shifted threshold for activation positive, but I(Na) increased positive to -40 mV, causing the current-voltage curves to cross over. When availability initially was low, increased availability induced by Gd(3+) dominated the response at test potentials positive to -40 mV. The results indicate that Gd(3+) has complex effects on cardiac Na(+) channels. Independent of holding potential, Gd(3+) is a potent I(Na) blocker near threshold potential, and inhibition of I(Na) by Gd(3+) is likely to contribute to suppression of stretch-induced arrhythmias.
Immediate and long‐term results of radiofrequency ablation of pulmonary vein ectopy for cure of paroxysmal atrial fibrillation using a focal approach (2002)

This series highlights the low long-term success rate of RFA to cure AF by targeting pulmonary vein initiators using a focal approach. Electrical pulmonary vein isolation may provide better long-term results.
Development of large DNA methods for plants: molecular cloning of large segments of<i>Arabidopsis</i>and carrot DNA into yeast (1988)

Procedures for the preparation, analysis and cloning of large DNA molecules from two different plant species are described. Arabidopsis and carrot protoplasts were used for the preparation of large DNA molecules in agarose "plugs" or in solution. Pulsed-field gel electrophoresis (PFGE) analysis of large plant DNA preparations using a contour-clamped homogeneous field (CHEF) apparatus indicated that the size of the DNA was at least 12 Mb. Large DNA preparations were shown to be useful for restriction enzyme analysis of the Arabidopsis genome using both frequent and infrequent cutting enzymes and for the molecular cloning of large segments of DNA into yeast using artificial chromosome (YAC) vectors. PFGE and blot hybridization analysis of Arabidopsis and carrot DNA-containing YACs indicated that both unique and highly repeated DNA sequences were represented in these libraries.
Ultrasmall Nanoplatforms as Calcium‐Responsive Contrast Agents for Magnetic Resonance Imaging (2015)

The preparation of ultrasmall and rigid platforms (USRPs) that are covalently coupled to macrocycle-based, calcium-responsive/smart contrast agents (SCAs), and the initial in vitro and in vivo validation of the resulting nanosized probes (SCA-USRPs) by means of magnetic resonance imaging (MRI) is reported. The synthetic procedure is robust, allowing preparation of the SCA-USRPs on a multigram scale. The resulting platforms display the desired MRI activity—i.e., longitudinal relaxivity increases almost twice at 7 T magnetic field strength upon saturation with Ca(2+). Cell viability is probed with the MTT assay using HEK-293 cells, which show good tolerance for lower contrast agent concentrations over longer periods of time. On intravenous administration of SCA-USRPs in living mice, MRI studies indicate their rapid accumulation in the renal pelvis and parenchyma. Importantly, the MRI signal increases in both kidney compartments when CaCl2 is also administrated. Laser-induced breakdown spectroscopy experiments confirm accumulation of SCA-USRPs in the renal cortex. To the best of our knowledge, these are the first studies which demonstrate calcium-sensitive MRI signal changes in vivo. Continuing contrast agent and MRI protocol optimizations should lead to wider application of these responsive probes and development of superior functional methods for monitoring calcium-dependent physiological and pathological processes in a dynamic manner.
Effects of component molecular weight on the viscoelastic properties of thermoreversible supramolecular ion gels via hydrogen bonding (2012)

We describe a thermoreversible supramolecular ion gel system consisting of a poly(2-vinylpyridine-b-ethylene oxide-b-2-vinylpyridine) (P2VP-PEO-P2VP) triblock copolymer, a poly(4-vinylphenol) (PVPh) linear homopolymer, and a room-temperature ionic liquid, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ([EMI][TFSA]). Aggregates of intermolecularly hydrogen-bonded PVPh cross-linkers form cross-links, connecting P2VP-PEO-P2VP triblock chains into a transient polymer network through hydrogen bonding with the P2VP endblocks. The viscoelastic properties of the resulting gels are strongly temperature-dependent, as manifested by the 15 orders of magnitude variation in the longest relaxation time (τ1) from the gel temperature (Tgel) down to room temperature. Wide temperature- and frequency-independent rubbery plateaus are distinct, indicating the formation of a well-defined network structure. The applicability of time-temperature superposition to this system is striking, suggesting the invariance of the underlying relaxation mechanism. The terminal relaxation dynamics of these hydrogen-bonded supramolecular networks is dramatically retarded upon increasing the P2VP endblock length. In contrast, their viscoelastic properties are relatively insensitive to the PVPh cross-linker length. These results are consistent with the hypothesis that τ1 is determined by the average lifetime of a P2VP ↔ PVPh association, which is directly related to the number of hydrogen bonds involved. Besides their potential applications in various electrochemical devices, these materials might also be used in surface coatings, where thermally reversible and sensitive viscoelastic properties are highly advantageous.
Radiation Evaluation of the Texas Instruments TPS7H2201-SP eFuse (2019)

Single Event Effects and Total Ionizing Dose characterization results for the TPS7H2201-SP are summarized. The data shows the device is SEL-free (at T$\approx$125 °C), SEB-free, SEGR-free, SEFI-free and SET-free (at T$\approx$23 °C) up to LET <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">EFF</inf> =75 MeV$\cdot$ cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /mg and across the full electrical specifications. The eFuse is also ELDRS-free with a TID rating of 100 krad(Si).
Purification, cloning and autoproteolytic processing of an aspartic proteinase from Centaurea calcitrapa (2000)

Plant aspartic proteinases (APs) have been isolated from several seed and leaf sources but the only well characterized enzymes from flowers are cardosins and cyprosins from cardoon, Cynara cardunculus L. Here we report a full-length cDNA clone encoding an AP named cenprosin from the flowers of Centaurea calcitrapa L., a thistle related to cardoon. As found for all eukaryotic APs, the deduced primary sequence consists of a signal sequence, a propart and a mature enzyme. In addition, an internal sequence region of 104 residues typical only of plant APs (a plant-specific insert) is present in the primary structure. Northern analysis revealed that the strongest expression is in fresh flowers. The enzyme is also expressed in fairly high amounts in seeds and in leaves, a feature not detected for cardoon APs. The corresponding enzyme was purified in its precursor form from fresh flowers using ammonium-sulfate precipitation followed by ion-exchange and hydrophobic-interaction chromatography. The processing of the precursor into its mature form was studied in vitro. The enzyme underwent autocatalytic processing at pH 3.0 resulting in two chains of 16 and 30 kDa. When dried flowers were used as a starting material for purification, only 16- and 30-kDa chains were obtained, suggesting that autoproteolytic activation of procenprosin in vivo occurs mainly during drying of the flowers. This may indicate a specific degradative role for the enzyme during senescence of the flowers.
Detection of occult paroxysmal atrial fibrilation by implantable long-term electrocardiographic monitoring in cryptogenic stroke and transient ischemic attack population: a study protocol for prospective matched cohort study (2015)

ClinicalTrials.gov: NCT02216370 .
Effect of tannins on starch digestibility and tmen of triticale and semipurified starches from triticale and field beans (1994)

1. The effects of field bean tannin-containing hulls (T-hulls), non-tannin hulls (NT-hulls) and tannin extract on starch digestibilities and TMEn of triticale and semipurified starches from triticale and field beans were evaluated with adult cockerels and 3-week-old-chicks. 2. For both cockerels and chicks, the digestibility and TMEn of semipurified starches from triticale were higher than those from beans. Starch digestibilities of triticales (range 99.1 to 97.7%), of semipurified starches from triticales (range 96.5 to 89.9%) and from field beans (range 75.4 to 71.6%) were similar for both cockerels and chicks. 3. The addition of NT-hulls improved, in general, the digestibility of semipurified starches for both chicks and cockerels, which suggests that fibre improves the digestion of semipurified starches. 4. The effects of tannins of T-hulls on semipurified starch from beans and from triticale were different. Tannins always decreased the digestibility and TMEn of semipurified starch from field beans but only decreased the digestibility and TMEn of semipurified starch from triticale when fed to chicks, but not when fed to cockerels. 5. The addition of tannin extract always decreased the digestibility of semipurified starches by a greater amount than T-hulls, which supports the idea that the effect of tannins depends on the quantity of tannin ingested.
Fluoropolymer resists for 157-nm lithography (2002)

Fluoropolymers are key materials for single-layer resists in 157-nm lithography. We investigated main-chain fluorinated polymers and found that the incorporation of fluorine atoms into polymer backbones such as that in tetrafluoroethylene and monocyclic monomers reduced their absorption coefficients to less than 1 micrometers <SUP>-1</SUP> at 157 nm, while side-chain fluorinated polymers had absorption coefficients of 2 to 3 micrometers <SUP>-1</SUP>. The main-chain fluorinated polymers also showed good solubility in a standard alkaline developer and their dry-etching resistance was comparable to that of a ArF resist. Prototype positive-tone resists had good sensitivities of less than 10 mJ/cm<SUP>2</SUP>, and they exhibited fine imaging resolution with 80-nm dense patterns. The resists can be used to obtain 300-nm-thick films.
Text-to-Image Generation Grounded by Fine-Grained User Attention (2020)

Localized Narratives is a dataset with detailed natural language descriptions of images paired with mouse traces that provide a sparse, fine-grained visual grounding for phrases. We propose TReCS, a sequential model that exploits this grounding to generate images. TReCS uses descriptions to retrieve segmentation masks and predict object labels aligned with mouse traces. These alignments are used to select and position masks to generate a fully covered segmentation canvas; the final image is produced by a segmentation-to-image generator using this canvas. This multi-step, retrieval-based approach outperforms existing direct text-to-image generation models on both automatic metrics and human evaluations: overall, its generated images are more photo-realistic and better match descriptions.
Computerized management of respiratory care. (1993)

Respiratory care as an organized discipline is only about 45 years old, and the management of this dynamic allied health profession has usually been characterized by a demand-for-service mentality. As pressure continues to control costs, those departments that maximize quality patient care cost-effectively with thoroughly documented outcomes are in a better position to compete for future resources. The practice of respiratory care is changing as is the practice of medical care in general. Accountability for resource consumption and the quality of the product delivered are essential elements in the delivery of respiratory modalities. We have developed and implemented a comprehensive patient-data-based approach to the management of respiratory care. The essential elements of this approach are (1) relative-value-unit procedure base; (2) individual, shift, and department productivity that is attached to the annual performance review process; (3) management reporting on a 24-hour basis, with biweekly review at the management level; (4) development and implementation of a comprehensive patient-data-documentation system that permits automatic patient billing and 100% data review for quality-assurance documentation; (5) the development of a medical alerting system that alerts the Medical Director and Respiratory Care staff to potentially harmful events that, if untreated, may result in increased morbidity or mortality; and (6) the development of concurrent and retrospective tools for patient-outcomes research. These functions are supported by an active Medical Informatics Department that is nationally recognized in medical computing and logic application.
Diamond photonic band gap synthesis by umbrella holographic lithography (2006)

The authors demonstrate that optical interference lithography yields diamond photonic band gap (PBG) architectures with PBGs as large as 25% when the exposed photoresist is replicated with silicon. This process utilizes five linearly polarized beams propagating from the same half-space (umbrella configuration), a setup considerably simpler than the widely studied counterpropagating four-beam setup. Using the umbrella configuration, this diamond structure is also achieved by two or more exposures using fewer interfering laser beams.
The phononic lattice solid by interpolation for modeling P‐waves in heterogeneous media (1993)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1993The phononic lattice solid by interpolation for modeling P‐waves in heterogeneous mediaAuthors: Lian‐Jie HuangPeter MoraLian‐Jie HuangInstitut de Physique du Globe de Paris and Peter MoraInstitut de Physique du Globe de Parishttps://doi.org/10.1190/1.1822440 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822440FiguresReferencesRelatedDetailsCited byThe Phononic Lattice Solid With Fluids For Modelling Non-Linear Solid-Fluid InteractionsGeophysical Journal International, Vol. 117, No. 2 SEG Technical Program Expanded Abstracts 1993ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1993 Pages: 1396 publication data© 1993 Copyright © 1993 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Lian‐Jie Huang and Peter Mora, (1993), "The phononic lattice solid by interpolation for modeling P‐waves in heterogeneous media," SEG Technical Program Expanded Abstracts : 208-211. https://doi.org/10.1190/1.1822440 Plain-Language Summary PDF DownloadLoading ...
Congestion and starvation detection in ripple FIFOs (2003)

High-speed asynchronous ripple FIFOs may be easily embedded in synchronous environments and can elegantly handle the problem of forwarding data between clock domains. In cases where the producer and consumer clock rates differ, however, the issue of flow control has remained a problem. Compared to more traditional pointer FIFOs, the highly dynamic internal state of ripple FIFOs makes it difficult to estimate the instantaneous occupancy, or "fullness" of the FIFO. To prevent overflow, the sender must know when the FIFO is getting too full. To prevent undertow, the receiver must know when the FIFO is getting too empty. In this paper, we present a novel method for estimating ripple FIFO occupancy by detecting regions of local data congestion and data starvation. The solution is very simple and is suitable for use with many common FIFO protocols. The core idea involves the use of a phase comparator circuit to monitor the relative timing of control signals at FIFO stage boundaries.
High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1) (2018)

Antibodies to platelet-specific antigens are responsible for 2 clinically important bleeding disorders: posttransfusion purpura and fetal/neonatal alloimmune thrombocytopenia (FNAIT). The human platelet-specific alloantigen 1a/1b (HPA-1a/1b; also known as Pl<sup>A1/A2</sup>) alloantigen system of human platelet membrane glycoprotein (GP) IIIa is controlled by a Leu33Pro polymorphism and is responsible for ∼80% of the cases of FNAIT. Local residues surrounding polymorphic residue 33 are suspected to have a profound effect on alloantibody binding and subsequent downstream effector events. To define the molecular requirements for HPA-1a alloantibody binding, we generated transgenic mice that expressed murine GPIIIa (muGPIIIa) isoforms harboring select humanized residues within the plexin-semaphorin-integrin (PSI) and epidermal growth factor 1 (EGF1) domains and examined their ability to support the binding of a series of monoclonal and polyclonal HPA-1a-specific antibodies. Humanizing the PSI domain of muGPIIIa was sufficient to recreate the HPA-1a epitope recognized by some HPA-1a-specific antibodies; however, humanizing distinct amino acids within the linearly distant but conformationally close EGF1 domain was required to enable binding of others. These results reveal the previously unsuspected complex heterogeneity of the polyclonal alloimmune response to this clinically important human platelet alloantigen system. High-resolution mapping of this alloimmune response may improve diagnosis of FNAIT and should facilitate the rational design and selection of contemplated prophylactic and therapeutic anti-HPA-1a reagents.
Entity-based Enrichment for Information Extraction and Retrieval (2021)

Thanks to the Spitzer Space Telescope, the infrared (IR) emission have been better studied in the past decades, as well as its relations to star formation rates (SFR) and the calibrations of IR emissions as SFR indicators. However, the far infrared (FIR) emission are still understudied, especially at the sub-galactic region scales. In this dissertation, I present new ground--based observations in the light of the infrared hydrogen recombination line Br[gamma] (2.16~mu m) of a sample of KINGFISH (Key Insights on Nearby Galaxies: a Far-Infrared Survey with Herschel) galaxies. The Br[gamma] emission line offers the double advantage of directly tracing ionizing photons and of being relatively insensitive to the effects of dust attenuation. It is therefore a relatively unbiased reference star formation rate (SFR) indicator that I use to establish the calibrations of the Herschel PACS 70, 100 and 160~mu m emission as SFR tracers on sub--galactic scales. I confirm with higher statistical accuracy the dependence of the SFR calibrations on metallicity and star formation timescale. I also provide calibrations for SFR indicators for HII regions that combine the observed H[alpha] with one of the three IR bands. I find significant diffuse IR emission not related to current star formation activity in galaxies, implying major impact of diffuse stellar population on the dust heating in nearby galaxies. I make comparisons among different SFR(IR) indicators and provide interpretations on the comparisons.
Noninvasive cardiac output measurements in patients with pulmonary hypertension (2012)

Pulmonary hypertension (PH) is characterised by a progressive decline in cardiac output (CO) and right heart failure. NICOM® (noninvasive cardiac output monitor) is a bioreactance-based technology that has been broadly validated, but its specific application in right heart failure and PH is unknown. Cardiac catheterisation was performed in 50 consecutive patients with PH. CO measurements were performed using three different methods (thermodilution, Fick and NICOM) at baseline and after vasodilator challenge. We compared the precision (coefficient of variation) and accuracy of NICOM compared to thermodilution and Fick. The mean CO (L·min(-1)) at baseline as measured by the three methods was 4.73±1.15 (NICOM), 5.69±1.74 (thermodilution) and 4.84±1.39 (Fick). CO measured by NICOM was more precise than by thermodilution (3.5±0.3% versus 9.6±6.1%, p<0.001). Bland-Altman analyses comparing NICOM to thermodilution and Fick revealed bias and 95% limits of agreement that were comparable to those comparing Fick to thermodilution. All three CO methods detected an increase in CO in response to vasodilator challenge. CO measured via NICOM is precise and reliably measures CO at rest and changes in CO with vasodilator challenge in patients with PH. NICOM may allow for the noninvasive haemodynamic assessment of patients with PH and their response to therapy.
[Circadian rhythm of cortisol secretion in diabetes mellitus patients]. (1984)

The circadian rhythm of cortisol secretion was studied in 46 patients with diabetes mellitus. According to the complex criteria the rhythm was lost in 41 per cent of the examined. The rhythm changes do not depend on sex, blood sugar level, type of diabetes, vascular degenerative complications. A tendency was observed of reduction of the difference between the morning and evening cortisolemia with the advancement of the disease. The results obtained suggest a disorder in the functional integrity between hypothalamus and hypophyseal-suprarenal axis in a considerable part of the diabetics.