gebhart/patrepeval huggingface dataset:
Fruits and vegetables and lung cancer: Findings from the European prospective investigation into cancer and nutrition (2003)

Intake of fruits and vegetables is thought to protect against the development of lung cancer. However, some recent cohort and case-control studies have shown no protective effect. We have assessed the relation between fruit and vegetable intake and lung cancer incidence in the large prospective investigation on diet and cancer, the European Prospective Investigation Into Cancer and Nutrition (EPIC). We studied data from 478,021 individuals that took part in the EPIC study, who were recruited from 10 European countries and who completed a dietary questionnaire during 1992-1998. Follow-up was to December 1998 or 1999, but for some centres with active follow-up to June 2002. During follow-up, 1,074 participants were reported to have developed lung cancer, of whom 860 were eligible for our analysis. We used the Cox proportional hazard model to determine the effect of fruit and vegetable intake on the incidence of lung cancer. We paid particular attention to adjustment for smoking. Relative risk estimates were obtained using fruit and vegetable intake categorised by sex-specific, cohort-wide quintiles. After adjustment for age, smoking, height, weight and gender, there was a significant inverse association between fruit consumption and lung cancer risk: the hazard ratio for the highest quintile of consumption relative to the lowest being 0.60 (95% Confidence Interval 0.46-0.78), p for trend 0.0099. The association was strongest in the Northern Europe centres, and among current smokers at baseline, and was strengthened when the 293 lung cancers diagnosed in the first 2 years of follow-up were excluded from the analysis. There was no association between vegetable consumption or vegetable subtypes and lung cancer risk. The findings from this analysis can be regarded as re-enforcing recommendations with regard to enhanced fruit consumption for populations. However, the effect is likely to be small compared to smoking cessation.
Compact fiber laser approach to 589 nm laser guide stars (2004)

We are developing an all-fiber 589 nm laser system for laser-guided adaptive optics by sum-frequency mixing 1583 nm Er/Yb:doped and 938 nm Nd:silica fiber lasers in a periodically poled crystal. System design and performance will be presented.
Cation ratio of soil structural stability (CROSS). (2010)

Sodium salts tend to dominate salt-affected soils and groundwater in Australia and therefore, sodium adsorption ratio (SAR) is being used to parameterize soil sodicity and the effects of sodium on soil structure. Recent reports, however, now draw attention to elevated concentrations of potassium and/or magnesium in some soils naturally and also as a result of increasing irrigation with recycled water in Australia. Therefore, there is a need to derive and define a new ratio of these cations in place of SAR, which will indicate the effects of Na and K on clay dispersion and Ca and Mg on flocculation. Rengasamy and Sumner (1998) derived the flocculation power of these cations and on this basis Rengasamy (unpublished) defined the cation ratio of soil structural stability (CROSS). This paper gives the results of an experiment conducted on ten soil samples on hydraulic conductivity using a number of artificially prepared irrigation waters, containing different proportions of the cations Ca, Mg, K and Na. The relative changes in hydraulic conductivity of these soils reflected the flocculating power of the cations, compared to the control treatment of using CaCl2 solution. Clay dispersion was found to be highly correlated to CROSS rather than to SAR.
Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage (1999)

Thioredoxin (TRX) plays important biological roles both in intra- and extracellular compartments, including in regulation of various intracellular molecules via thiol redox control. We produced TRX overexpressing mice and confirmed that there were no anatomical and physiological differences between wild-type (WT) mice and TRX transgenic (Tg) mice. In the present study we subjected mice to focal brain ischemia to shed light on the role of TRX in brain ischemic injury. At 24 hr after middle cerebral artery occlusion, infarct areas and volume were significantly smaller in Tg mice than in WT mice. Moreover neurological deficit was ameliorated in Tg mice compared with WT mice. Protein carbonyl content, a marker of cellular protein oxidation, in Tg mice showed less increase than did that of WT mice after the ischemic insult. Furthermore, c-fos expression in Tg mice was stronger than in WT mice 1 hr after ischemia. Our results suggest that transgene expression of TRX decreased ischemic neuronal injury and that TRX and the redox state modified by TRX play a crucial role in brain damage during stroke.
Word Sense Induction for Novel Sense Detection (2012)

We apply topic modelling to automatically induce word senses of a target word, and demonstrate that our word sense induction method can be used to automatically detect words with emergent novel senses, as well as token occurrences of those senses. We start by exploring the utility of standard topic models for word sense induction (WSI), with a pre-determined number of topics (=senses). We next demonstrate that a non-parametric formulation that learns an appropriate number of senses per word actually performs better at the WSI task. We go on to establish state-of-the-art results over two WSI datasets, and apply the proposed model to a novel sense detection task. 1
Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells (2022)

Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic reprograming during therapeutic resistance development is under-studied. Here, through high-throughput stimulated Raman scattering imaging and single cell analysis, we find that cisplatin-resistant cells exhibit increased fatty acids (FA) uptake, accompanied by decreased glucose uptake and lipogenesis, indicating reprogramming from glucose to FA dependent anabolic and energy metabolism. A metabolic index incorporating glucose derived anabolism and FA uptake correlates linearly to the level of cisplatin resistance in ovarian cancer (OC) cell lines and primary cells. The increased FA uptake facilitates cancer cell survival under cisplatin-induced oxidative stress by enhancing beta-oxidation. Consequently, blocking beta-oxidation by a small molecule inhibitor combined with cisplatin or carboplatin synergistically suppresses OC proliferation in vitro and growth of patient-derived xenografts in vivo. Collectively, these findings support a rapid detection method of cisplatin-resistance at single cell level and a strategy for treating cisplatin-resistant tumors.
Introduction (2014)

Christ’s life, as related through the Gospel narratives and early Apocrypha, was subject to a riot of literary-devotional adaptation in the medieval period. This collection provides a series of groundbreaking studies centring on the devotional and cultural significance of Christianity’s pivotal story during the Middle Ages. The collection represents an important milestone in terms of mapping the meditative modes of piety that characterize a number of Christological traditions, including the Meditationes vitae Christi and the numerous versions it spawned in both Latin and the vernacular. A number of chapters in the volume track how and why meditative piety grew in popularity to become a mode of spiritual activity advised not only to recluses and cenobites as in the writings of Aelred of Rievaulx, but also reached out to diverse lay audiences through the pastoral regimens prescribed by devotional authors such as the Carthusian prior Nicholas Love in England and the Parisian theologian and chancellor of the University of Paris, Jean Gerson. Through exploring these texts from a variety of perspectives - theoretical, codicological, theological - and through tracing their complex lines of dissemination in ideological and material terms, this collection promises to be invaluable to students and scholars of medieval religious and literary culture.
Hubble, Chandra and Keck Constraints on Massive Galaxy Clusters at z=0.2 and z=0.5 (2004)

I present recent observations from two Hubble Space Telescope(HST)/ACS programs that target the most X–ray luminous and thus (presumably) most massive galaxy clusters at .To search for other articles by the author(s) go to: http://adsabs.harvard.edu/abstract_service.html
Developing plug-and-play spacecraft systems: NASA Goddard Space Flight Center's (GSFC) Essential Services Node (ESN) (2002)

The phrase "plug-and-play" refers to hardware and software devices that, after being installed ("plugged in"), can immediately be used ("played with"). The system can be used for a specific application without requiring additional software programming or hardware design. The Essential Services Node (ESN) takes a big step in moving space systems to the "plug and play" environment of commercial systems. Systems that use the ESN to interface subsystems to the spacecraft bus (either MILSTD-1553B or MIL-STD-1773) provide a standard interface to both the sub-systems and the spacecraft bus. The ESN is a multi-chip module (MCM) that contains an ASIC, memory devices, and analog circuitry. The ASIC contains a microprocessor, a MIL-STD-1553B/-1773 bus interface, and many industry standard devices. The memory includes program-, data- and shared-RAM. The analog logic includes a 16-channel A/D converter, an 8-channel 1.0 mA current source, and an analog power strobing circuit. The ESN MCM is a low-power (<1 W), lowcost (<$25k), lightweight (2.6"/spl times/2.6"/spl times/0.3"), rad-hard (>100K), industry standard, spacecraft control and data system, which eliminates custom interfaces by choosing a set of industry standard interfaces. This paper describes how the ESN provides a standard interface to the spacecraft's bus and its sub-systems. It also describes the plug-and-play standard, Open Firmware, and our plans to port it to the spacecraft environment.
Enzyme-free signal amplification in the DNAzyme sensor via target-catalyzed hairpin assembly (2012)

A simple, highly sensitive and enzyme-free DNAzyme sensor based on target-catalyzed hairpin assembly is developed, which permits detection of 0.1 pM target DNA. Furthermore, this DNAzyme sensor is capable of detecting target DNA in real samples because of its high selectivity.
Cyclic AMP Potentiates Vascular Endothelial Cadherin-Mediated Cell-Cell Contact To Enhance Endothelial Barrier Function through an Epac-Rap1 Signaling Pathway (2004)

Cyclic AMP (cAMP) is a well-known intracellular signaling molecule improving barrier function in vascular endothelial cells. Here, we delineate a novel cAMP-triggered signal that regulates the barrier function. We found that cAMP-elevating reagents, prostacyclin and forskolin, decreased cell permeability and enhanced vascular endothelial (VE) cadherin-dependent cell adhesion. Although the decreased permeability and the increased VE-cadherin-mediated adhesion by prostacyclin and forskolin were insensitive to a specific inhibitor for cAMP-dependent protein kinase, these effects were mimicked by 8-(4-chlorophenylthio)-2'-O-methyladenosine-3', 5'-cyclic monophosphate, a specific activator for Epac, which is a novel cAMP-dependent guanine nucleotide exchange factor for Rap1. Thus, we investigated the effect of Rap1 on permeability and the VE-cadherin-mediated cell adhesion by expressing either constitutive active Rap1 or Rap1GAPII. Activation of Rap1 resulted in a decrease in permeability and enhancement of VE-cadherin-dependent cell adhesion, whereas inactivation of Rap1 had the counter effect. Furthermore, prostacyclin and forskolin induced cortical actin rearrangement in a Rap1-dependent manner. In conclusion, cAMP-Epac-Rap1 signaling promotes decreased cell permeability by enhancing VE-cadherin-mediated adhesion lined by the rearranged cortical actin.
Advanced Computing Architectures for Cognitive Processing (2009)

Abstract : This report describes the research results of the Advanced Computing Architectures for Cognitive Processing project. Cognitive processing algorithms promise to transform Air Force mission capabilities if practical, deployable systems can be created. Advanced computing architectures based on approaches such as polygranular parallel processing (e.g., high performance reconfigurable computing), data intensive systems (e.g., processors in memory or intelligent RAM), configurable/morphable processors, DNA computing, and quantum computing could make embedded cognitive processing feasible. Given the diverse new computational technologies that are now emerging, this report presents an assessment of the effectiveness of various types of computational architectures for cognitive processing for Air Force systems acquisition.
Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure (1995)

Measurement of sTNF-Rs, in addition to antigenic and bioactive TNF-alpha, is essential for evaluation of the activation of this cytokine in CHF. Both sTNF-Rs increase in preterminal patients with severe CHF and might inhibit the in vitro cytotoxicity of TNF-alpha. Antigenic TNF-alpha also increases in severe CHF. The increased levels of sTNF-RII independently correlate with poor short-term prognosis.
Neutralizing Antibodies Inhibit Axonal Spread of Herpes Simplex Virus Type 1 to Epidermal Cells In Vitro (1999)

The ability of antibodies to interfere with anterograde transmission of herpes simplex virus (HSV) from neuronal axons to the epidermis was investigated in an in vitro model consisting of human fetal dorsal root ganglia innervating autologous skin explants in a dual-chamber tissue culture system. The number and size of viral cytopathic plaques in epidermal cells after axonal transmission from HSV type 1 (HSV-1)-infected dorsal root ganglionic neurons were significantly reduced by addition to the outer chamber of neutralizing polyclonal human sera to HSV-1, of a human recombinant monoclonal group Ib antibody to glycoprotein D (gD), and of rabbit sera to HSV-1 gB and gD but not by rabbit anti-gE or anti-gG. A similar pattern of inhibition of direct infection of epidermal cells by these antibodies was observed. High concentrations of the monoclonal anti-gD reduced transmission by 90%. Rabbit anti-gB was not taken up into neurons, and human anti-gD did not influence spread of HSV in the dorsal root ganglia or axonal transport of HSV antigens when applied to individual dissociated neurons. These results suggest that anti-gD and -gB antibodies interfere with axonal spread of HSV-1, possibly by neutralizing HSV during transmission across an intercellular gap between axonal termini and epidermal cells, and thus contribute to control of HSV spread and shedding. Therefore, selected human monoclonal antibodies to protective epitopes might even be effective in preventing epidermis-to-neuron transmission during primary HSV infection, especially neonatal infection.
Evaluating an Improved Method to Determine Layered Fibre Orientation by Sheet Splitting (2007)

First the most commonly applied methods are reviewed. Then a new method is introduced employing the laminate method for sheet splitting, a high resolution scanner for imaging and fibre segment image analysis for fibre orientation measurement. One advantage of the new method is that it permits arithmetic correction of uneven sheet splitting which reduces noise in the FO measurement. The main part of the paper is devoted to the evaluation of the new method. Repeatability of the measurement is good. The influence of the sheet splitting process on the measured fibre orientation is assessed by analyzing isotropic laboratory handsheets and oriented machine made sheets. Only minor influence of the sheet splitting on the result is found for handsheets, the measured fibre orientation was nearly isotropic. For oriented paper differences of the measured FO between sheet splitting in MD and CD was found. Overall the effect of sheet splitting on the measured results was lower than expected. The experiments indicate that the influence of sheet splitting on the measured FO is, although undoubtedly existing, certainly low enough to permit meaningful results. It is discussed, that the predominantly layered structure of the fibres in paper is the reason why sheet splitting can be applied in combination with fibre orientation measurement.
Towards a Better Understanding of the Genetic and Physiological Basis for Nitrogen Use Efficiency in Maize (2001)

To enhance our understanding of the genetic basis of nitrogen use efficiency in maize (Zea mays), we have developed a quantitative genetic approach by associating metabolic functions and agronomic traits to DNA markers. In this study, leaves of vegetative recombinant inbred lines of maize, already assessed for their agronomic performance, were analyzed for physiological traits such as nitrate content, nitrate reductase (NR), and glutamine synthetase (GS) activities. A significant genotypic variation was found for these traits and a positive correlation was observed between nitrate content, GS activity and yield, and its components. NR activity, on the other hand, was negatively correlated. These results suggest that increased productivity in maize genotypes was due to their ability to accumulate nitrate in their leaves during vegetative growth and to efficiently remobilize this stored nitrogen during grain filling. Quantitative trait loci (QTL) for various agronomic and physiological traits were searched for and located on the genetic map of maize. Coincidences of QTL for yield and its components with genes encoding cytosolic GS and the corresponding enzyme activity were detected. In particular, it appears that the GS locus on chromosome 5 is a good candidate gene that can, at least partially, explain variations in yield or kernel weight. Because at this locus coincidences of QTLs for grain yield, GS, NR activity, and nitrate content were also observed, we hypothesize that leaf nitrate accumulation and the reactions catalyzed by NR and GS are coregulated and represent key elements controlling nitrogen use efficiency in maize.
Post-training stimulation of the basolateral amygdala improves spatial learning in rats with lesion of the fimbria-fornix (2005)

This is the first evidence that stimulating the BLA can positively influence the learning abilities of lesioned animals. Further experiments should contribute to improve the stimulation paradigms to make it more effective, if possible.
Detection and Discrimination of Bacterial Colonies with Mueller Matrix Imaging (2018)

The polarization imaging technique is a powerful approach to probe microstructural and optical information of biological structures (e.g., tissue samples). Here, we have studied the polarization properties of different bacterial colonies in order to evaluate the possibility of bacterial detection and discrimination. In this regard, we have taken the backscattering Mueller matrix images of four different bacteria colonies (i.e., Escherichia coli, Lactobacillus rhamnosus, Rhodococcus erythropolis, and Staphylococcus aureus). Although the images have the potential to distinguish qualitatively different bacterial colonies, we explored more accurate and quantitative parameters criteria for discrimination of bacterial samples; more specifically, we have exploited the Mueller matrix polar decomposition (MMPD),frequency distribution histogram (FDH), and central moment analysis method. The outcomes demonstrated a superior capacity of Mueller matrix imaging, MMPD, and FDH in bacterial colonies identification and discrimination. This approach might pave the way for a reliable, efficient, and cheap way of identification of infectious diseases.
Fringe projection profilometry based on a novel phase shift method (2011)

Fringe projection profilometry is generally used to measure the 3D shape of an object. In oblique-angle projection, the grating fringe cycle is broadened on the reference surface. A well-fitted, convenient, and quick cycle correction method is proposed in this study. Based on the proposed method, an accurate four-step phase shift method is developed. Comparative experiments show that the fringe projection profilometry based on the novel phase shift method can eliminate cycle error and significantly improve measurement accuracy. The relative error of the measurement is less than 1.5%. This method can be widely employed for measuring large objects.
Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway. (1995)

The metabolism of chylomicron remnants in mice deficient in low density lipoprotein receptor (LDLr) or apolipoprotein E (apoE) was compared with that of control C57BL/6J mice. Mice were injected intravenously with chylomicron-like emulsions labeled with radioactive lipids. Blood samples were taken at fixed time intervals from the retro-orbital sinus, and clearance rates of the lipoproteins were assessed from the decline in plasma radioactivities. To follow the intracellular pathway of remnants in the liver, emulsions labeled with a fluorescent cholesteryl ester (BODIPY) were injected, and liver sections were processed and assayed by laser confocal microscopy. Catabolism of remnant cholesteryl esters was assessed by injecting emulsions labeled with cholesteryl[1-14C]oleate and measuring the expired CO2 from each animal. In apoE-deficient mice, remnant removal from plasma was totally impeded, while the clearance of remnants in LDLr-deficient mice was similar to that in C57BL/6J control mice. The confocal micrographs of livers 20 min after injection of fluorescent chylomicron-like emulsions showed evenly distributed fluorescent particles in the hepatocytes from control mice. In contrast, the fluorescent particles were mainly located in sinusoidal spaces in LDLr-deficient mice. Three hours after injection the livers from control mice showed few fluorescent particles, indicating that remnants have been catabolized, while the sections from LDLr-deficient mice were still highly fluorescent. Micrographs from apoE-deficient mice showed no fluorescent particles in the liver at any time after injection. Measurement of expired radioactive CO2 after injection of emulsions labeled in the fatty acid moiety of cholesteryl oleate indicated that remnant metabolism was slower in the LDLr-deficient mice and essentially nil in the apoE-deficient mice. Control mice had expired 50% of the injected label by 3 h after injection. We conclude that under normal circumstances, chylomicron remnants are rapidly internalized by LDLr and catabolized in hepatocytes, with a critical requirement for apoE. When LDLr is absent, remnants are taken up by a second apoE-dependent pathway, first to the sinusoidal space of the liver, with subsequent slow endocytosis and slow catabolism. Hepatic clearance via this second pathway is increased by heparin, inhibited by lactoferrin, heparinase, and suramin, and down-regulated by feeding a high fat diet.