gebhart/patrepeval huggingface dataset:
Synthesis and Evaluation of a Series of 2′-Deoxy Analogues of The Antiviral Agent 5,6-Dichloro-2-Isopropylamino-1-(β-L-Ribofuranosyl)-1H-Benzimidazole (1263W94) (2000)

A series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94) were synthesized and evaluated for activity against human cytomegalovirus (HCMV) and for cytotoxicity. The 2-substituents in the benzimidazole moiety correspond to those that were used in the 1263W94 series. In general, as was found in the 1263W94 series, cyclic and branched alkylamino groups were needed for potent activity against HCMV. Three analogues 3a, 3b and 3d were as potent as 1263W94. Further evaluation of two analogues, 3a and 3b, suggested that these 2'-deoxy analogues may act via a novel mechanism of action similar to that of 1263W94. These 2'-deoxy analogues generally lacked cytotoxicity in vitro. Pharmacokinetic parameters in mice and protein binding properties of 3a were quite similar to 1263W94. However, the oral bioavailability of 3a was only half of that observed for 1263W94.
A Novel, Low Cost, Disposable, Pediatric Pulsatile Rotary Ventricular Pump For Cardiac Surgery that Provides a Physiological Flow Pattern (2008)

Research is underway to develop a novel, low cost, disposable pediatric pulsatile rotary ventricular pump (PRVP) for cardiac surgery that provides a physiological flow pattern. This is believed to offer reduced morbidity and risk exposure within this population. The PRVP will have a durable design suitable for use in short- to mid-length prolonged support after surgery without changing pumps. The design is based on proprietary MC3 technology which provides variable pumping volume per stroke, thereby allowing the pump to respond to hemodynamic status changes of the patient. The novel pump design also possesses safety advantages that prevent retrograde flow, and maintain safe circuit pressures upon occlusion of the inlet and outlet tubing. The design is ideal for simple, safe and natural flow support. Computational methods have been developed that predict output for pump chambers of varying geometry. A scaled chamber and pump head (diameter = 4 in) were prototyped to demonstrate target performance for pediatrics (2 L/min at 100 rpm). A novel means of creating a pulsatile flow and pressure output at constant RPM was developed and demonstrated to create significant surplus hydraulic energy (>10%) in a simplified mock patient circuit.
Novel temporal domain hole filling based on background modeling for view synthesis (2012)

View synthesis is a technique to generate images/videos in a virtual viewpoint. In this paper, the dis-occlusion/hole problem in view synthesis is resolved from the temporal domain. By the fact that dis-occlusions belong to the background, firstly we build an online background under a newly designed Switchable Gaussian Model (SGM), owning to its computationally simplicity and scene adaptivity. Then, real textures in the dis-occlusions are able to be recovered with the built background. Experimental results have verified the improvements in rendering quality and computation complexity by comparing to the conventional spatial filling methods and other temporal filling methods.
Omnidirectional Structural Color (2010)

Avoiding angular-shift of an interference-based structural color remains a challenge. The design-criteria for first-ever omnidirectional structural colors have been discussed by treating a quarter-wave stack of alternating dielectric material layers as a one-dimensional photonic crystal.
CEST phase mapping using a length and offset varied saturation (LOVARS) scheme (2012)

Chemical exchange saturation transfer MRI is a promising new technique for cellular and molecular imaging. This contrast allows the detection of tumors and ischemia without the use of gadolinium as well as the design of microenvironment-sensitive probes that can be discriminated based on their exchange contrast properties and saturation frequency. Current acquisition schemes to detect and analyze this contrast suffer from sensitivity to spatial B0 inhomogeneity and low contrast-to-noise-ratio, which is an obstacle to widespread adoption of the technology. A new method to detect chemical exchange saturation transfer contrast is proposed here, termed "length and offset varied saturation" which acquires a set of images with the saturation parameters varied so as to modulate the exchange contrast. Either fast fourier transform or the general linear model can be employed to decompose the modulation patterns into separate sources of water signal loss. After transformation, a length and offset varied saturation phase map is generated, which is insensitive to B0 inhomogeneity. When collected on live mice bearing 9L gliosarcomas, and compared to the conventional asymmetry in the magnetization transfer ratio map using offset increment correction, the results show that length and offset varied saturation phase mapping obtains about three to four times contrast-to-noise-ratio and exhibits less B0 artifacts.
Thermal Expansivity and High-Temperature Oxidation Resistance of Fe&ndash;Cr&ndash;W Alloys (1999)

The heat-resistant alloys were investigated for the use of the separator in solid oxide fuel cells. To find out those alloys which have low thermal expansivity close to zirconia, the Fe–Cr–W system was surveyed with respect to the thermal expansion up to 1273 K and the oxidation resistance at 1273 and 1373 K. In the compositional range above 15 mass%Cr, the average coefficient of thermal expansion was low in the alloys containing 7 to 10 mass%W, and especially low, 12×10−6 K−1 or less, in the alloy containing about 9 mass%W. This is because, below the Curie temperature the expansivity is depressed due to ferromagnetism, while above the Curie temperature it is intrinsically low. Fe-18 mass%Cr-7 mass%W was found to have very good oxidation resistance comparable to the commercial superalloys of forming Cr2O3 scales, but Fe-18 mass%Cr-9 mass%W had poorly adherent scales.
Use of Conductive Materials to Enhance Lead‐Acid Battery Formation (1991)

The rate of formation of the lead‐acid battery plate is limited by the conductivity of the positive paste. Efforts to increase the paste conductivity which have been published are reviewed. A proprietary process developed at Johnson Controls for treating the positive plate with ozone to convert the lead oxide to conductive lead dioxide is described. Plate ozonation has two effects: (i) it enhances formation by creating a conductive layer on the plate surface, and (ii) it oxidizes the free lead in the paste to lead oxide.
Significant Increase in Prostaglandin E-Main Urinary Metabolite by Laxative Administration: Comparison with Ulcerative Colitis (2000)

Laxative administration induces production of prostaglandin E(2) as one of the chemical mediators, although its production grade is relatively low as compared with ulcerative colitis in the active phase.
Improved Separation of Acetaldehyde‐Induced Hemoglobin (1993)

A fast-eluting minor variant of hemoglobin A, designated as HbA1-AcH, appears elevated after the incubation of red blood cell hemolysates with acetaldehyde (AcH) and has been proposed as a diagnostic marker for alcoholism or as an indicator for heavy drinking. We have developed an improved HPLC separation of this peak and others elevated by AcH using a polyaspartic acid column (PolyCAT A, PolyLC, Inc.) and a nonlinear buffer gradient with pH changes from 6.6 to 6.8. Saline-washed red blood cells were treated with sodium acetate buffer (pH 5.5) to remove unstable Schiff bases, and then hemolyzed by addition of an equal volume of H2O and 0.4 volumes of CCI4. HbA1-AcH and several others, including two peaks in the HbA1a+b cluster, Hb Pre-A1c, and HbA1d3 were significantly increased by AcH incubation, and the changes were only partially reversible with time. Improved resolution of these peaks allows more accurate quantitation of AcH adducts of hemoglobin.
QRP08-1: Opinion Model for Estimating Video Quality of Videophone Services (2006)

We propose a computational opinion model for estimating video quality of videophone services. Opinion models for speech such as the E-model have been established and widely used; however, little attention has been given to opinion models for video quality estimation. Our proposed opinion model is useful as a network-planning tool for assessing several video parameters that affect the quality of videophone services. First, we established a function for estimating video quality affected by coding degradation, which expresses the quality of a video affected by coding bit rate and frame rate. Second, we established a packet loss degradation index that estimates the degree of video quality degradation due to packet loss. Finally, we integrated these two functions into the opinion model for estimating video quality. We applied this model for video quality estimation of a videophone service with various video formats and displayed video sizes. The results indicated that the estimation errors of our model were less than the mean of the 99% confidence intervals for the subjective scores. Therefore, our model could be applied to effective design, implementation, and management of videophone applications and communication networks.
Determining complex permittivity from propagation constant measurements with planar transmission lines (2013)

A new two-standard calibration procedure is outlined for determining the complex permittivity of materials from the propagation constant measured with planar transmission lines. Once calibrated, a closed-form expression for the material permittivity is obtained. The effects of radiation and conductor losses are accounted for in the calibration. The multiline technique, combined with a recently proposed planar transmission-line configuration, is used to determine the line propagation constant. An uncertainty analysis is presented for the proposed calibration procedure that includes the uncertainties associated with the multiline technique. This allows line dimensions and calibration standards to be selected that minimize the total measurement uncertainty. The use of air and distilled water as calibration standards gives relatively small measurement uncertainty. Permittivity measurement results for five liquids, covering a wide permittivity range, agree very closely with expected values from 0.5–5 GHz.
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants (2017)

RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic processes and have been implicated in numerous diseases, but targeting these enzymes remains a major challenge. We report the development of three ubiquitin variants (UbVs), each binding selectively to the RING or U-box domain of a distinct E3 ligase: monomeric UBE4B, phosphorylated active CBL, or dimeric XIAP. Structural and biochemical analyses revealed that UbVs specifically inhibited the activity of UBE4B or phosphorylated CBL by blocking the E2∼Ub binding site. Surprisingly, the UbV selective for dimeric XIAP formed a dimer to stimulate E3 activity by stabilizing the closed E2∼Ub conformation. We further verified the inhibitory and stimulatory functions of UbVs in cells. Our work provides a general strategy to inhibit or activate RING/U-box E3 ligases and provides a resource for the research community to modulate these enzymes.
A High-Resolution Time-of-Flight Mass Spectrometer With Laser Desorption and a Laser Ionization Source (1987)

ABSTRACT Details of the novel method of laser desorption with a low powered IR-laser and resonance-enhanced multiphoton ionization (REMPI) combined with a high-resolution Reflectron-Time-of-Flight (RETOF) mass spectrometer are explained. Different features of the method are discussed. Some results of mass spectrometric investigations of biomolecules are shown.
Narrowing the Gap between Theoretical and Practical Capacities in Li‐Ion Layered Oxide Cathode Materials (2017)

Abstract Although layered lithium oxides have become the cathode of choice for state‐of‐the‐art Li‐ion batteries, substantial gaps remain between the practical and theoretical energy densities. With the aim of supporting efforts to close this gap, this work reviews the fundamental operating mechanisms and challenges of Li intercalation in layered oxides, contrasts how these challenges play out differently for different materials (with emphasis on Ni–Co–Al (NCA) and Ni–Mn–Co (NMC) alloys), and summarizes the extensive corpus of modifications and extensions to the layered lithium oxides. Particular emphasis is given to the fundamental mechanisms behind the operation and degradation of layered intercalation electrode materials as well as novel modifications and extensions, including Na‐ion and cation‐disordered materials.
Allergen-specific immunotherapy of allergy and asthma: current and future trends (2009)

Allergen-specific immunotherapy is the only immunomodulatory and etiological therapy of allergy and asthma. Conventional specific immunotherapy (SIT) with whole-allergen extract is antigen specific, effective on multiple organs, efficient on asthma in defined conditions, provides long-lasting protection and is cost effective. Moreover, SIT is able to prevent the course of rhinitis to asthma. SIT has its drawbacks: the long duration of treatment, the unsatisfactory standardization of allergen extracts and a questionable safety level. Novel approaches are aimed at drastically reducing adverse anaphylactic events, shortening the duration of therapy and improving its efficacy. Novel promising approaches have based their formulation on a limited set of recombinant allergens or chimeric molecules as well as on hypoallergenic allergen fragments or peptides. The simultaneous use of adjuvants with immunomodulatory properties may contribute to improve both the safety and efficacy of allergen-SIT of allergy and asthma.
Elevated levels and functional capacity of soluble CD40 ligand in systemic lupus erythematosus sera (1999)

The soluble form of CD40L is present in the sera of most patients with SLE and may have the capacity to mediate B cell activation. Aberrant expression of CD40L might be predicted to result in activation of bystander B cells, including those that have encountered self antigens, and to contribute to autoantibody secretion.
Pregnancy-related steroids are potential negative regulators of B lymphopoiesis. (1994)

B lymphopoiesis is selectively suppressed in normal pregnant mice, suggesting that fluctuations in systemic hormone levels might influence local events within bone marrow. This has now been tested by sustained experimental elevation of sex steroids by hormone-containing pellet implants. We found that while numbers of total nucleated cells declined after treatment with estrone, beta-estradiol, or estriol, there was preferential suppression of B-lymphocyte lineage precursors. Progesterone pellets had no effect when used alone, but mice exposed to progesterone were sensitive to several-logarithm lower concentrations of estrogen. Changes in subpopulations of B-lymphocyte lineage cells with hormone pellets were similar to those previously recorded in pregnancy. B-lymphocyte lineage precursors in male and female mice were sensitive to these sex hormones. Acute treatment with single injections of water-soluble beta-estradiol allowed temporal effects on B-lineage cells to be documented. With this protocol, total numbers of nucleated cells and myeloid progenitor cells remained unchanged. Interleukin 7-responsive precursors dramatically declined within 1 day of injection, suggesting that estrogen influences that stage in the B-lymphocyte lineage. There was a subsequent sharp drop in small pre-B cells 4 days after this transient elevation in estrogen. These experiments demonstrate that B lymphopoiesis is sensitive to negative regulation by sex steroids. They extend findings made with pregnant animals and parallel previous studies of the thymus. Sex steroids might contribute to control of steady-state lymphopoiesis, and fluctuations in their levels could have implications for human disease.
Electronic structure of a graphene/hexagonal-BN heterostructure grown on Ru(0001) by chemical vapor deposition and atomic layer deposition: extrinsically doped graphene (2010)

A significant BN-to-graphene charge donation is evident in the electronic structure of a graphene/h-BN(0001) heterojunction grown by chemical vapor deposition and atomic layer deposition directly on Ru(0001), consistent with density functional theory. This filling of the lowest unoccupied state near the Brillouin zone center has been characterized by combined photoemission/k vector resolved inverse photoemission spectroscopies, and Raman and scanning tunneling microscopy/spectroscopy. The unoccupied σ*(Γ(1) +) band dispersion yields an effective mass of 0.05 m(e) for graphene in the graphene/h-BN(0001) heterostructure, in spite of strong perturbations to the graphene conduction band edge placement.
Specular surface inspection using structured highlight and Gaussian images (1990)

The structured highlight inspection method uses an array of point sources to illuminate a specular object surface. The point sources are scanned, and highlights on the object surface resulting from each source are used to derive local surface orientation information. The extended Gaussian image (EGI) is obtained by placing at each point on a Gaussian sphere a mass proportional to the area of elements on the object surface that have a specific orientation. The EGI summarizes shape properties of the object surface and can be efficiently calculated from structured highlight data without surface reconstruction. Features of the estimated EGI including areas, moments, principal axes, homogeneity measures, and polygonality can be used as the basis for classification and inspection. The structured highlight inspection system (SHINY) has been implemented using a hemisphere of 127 point sources. The SHINY system uses a binary coding scheme to make the scanning of point sources efficient. Experiments have used the SHINY system and EGI features for the inspection and classification of surface-mounted-solder joints.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modeling Favipiravir Antiviral Efficacy Against Emerging Viruses: From Animal Studies to Clinical Trials (2020)

In 2014, our research network was involved in the evaluation of favipiravir, an anti-influenza polymerase inhibitor, against Ebola virus. In this review, we discuss how mathematical modeling was used, first to propose a relevant dosing regimen in humans, and then to optimize its antiviral efficacy in a nonhuman primate (NHP) model. The data collected in NHPs were finally used to develop a model of Ebola pathogenesis integrating the interactions among the virus, the innate and adaptive immune response, and the action of favipiravir. We conclude the review of this work by discussing how these results are of relevance for future human studies in the context of Ebola virus, but also for other emerging viral diseases for which no therapeutics are available.
Isolation, structure, and synthesis of combretastatin A-2, A-3, and B-2 (1987)

Further investigation of the South African tree Combretumcaffrum (Combretaceae) for murine P388 lymphocytic leukemia (PS) cell-growth inhibitory substances has led to discovery of three new active constituents designated combretastatins A-2 (5a, PS ED 50 0.027 μg/mL), A-3 (5b, PS ED 50 0.026 μg/mL), and B-2 (3b, PS ED 50 0.32 μg/mL). Both combretastatins A-2 and A-3 were found to markedly inhibit tubulin polymerization. The structure of each combretastatin was firmly established by a combination of high resolution (400 MHz) 1 H and 13 C nuclear magnetic resonance and mass spectral analyses followed by total syntheses. The conversion of methyl gallate (7b) to combretastatin A-2 via intermediates 7c → 7d → 7e → 7a and 6a → 5a illustrates the practical synthetic route utilized for obtaining these substances. The Wittig reaction employed as the penultimate step in obtaining combretastatins A-3, afforded predominantly the natural Z isomer.
MMM (1991)

Article MMM: a user interface architecture for shared editors on a single screen Share on Authors: Eric A. Bier Xerox PARC, 3333 Coyote Hill Rd., Palo Alto, CA Xerox PARC, 3333 Coyote Hill Rd., Palo Alto, CAView Profile , Steven Freeman Cambridge University, Cambridge, England CB3 9EU Cambridge University, Cambridge, England CB3 9EUView Profile Authors Info & Claims UIST '91: Proceedings of the 4th annual ACM symposium on User interface software and technologyNovember 1991 Pages 79–86https://doi.org/10.1145/120782.120791Online:11 November 1991Publication History 96citation1,097DownloadsMetricsTotal Citations96Total Downloads1,097Last 12 Months25Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Enzyme-Linked Immunosorbent Assay with Conserved Immunoreactive Glycoproteins gp36 and gp19 Has Enhanced Sensitivity and Provides Species-Specific Immunodiagnosis of<i>Ehrlichia canis</i>Infection (2006)

Ehrlichia canis is the primary etiologic agent of canine monocytic ehrlichiosis, a globally distributed and potentially fatal disease of dogs. We previously reported on the identification of two conserved major immunoreactive antigens, gp36 and gp19, which are the first proteins to elicit an E. canis-specific antibody response, and gp200 and p28, which elicit strong antibody responses later in the acute phase of the infection. In this report, the sensitivities and specificities of five recombinant E. canis proteins for the immunodiagnosis of E. canis infection by an enzyme-linked immunosorbent assay (ELISA) were evaluated. Recombinant polypeptides gp36, gp19, and gp200 (N and C termini) exhibited 100% sensitivity and specificity for immunodiagnosis by the recombinant glycoprotein ELISA compared with the results obtained by an indirect fluorescent-antibody assay (IFA) for the detection of antibodies in dogs that were naturally infected with E. canis. Moreover, the enhanced sensitivities of gp36 and gp19 for immunodiagnosis by the recombinant glycoprotein ELISA compared to those obtained by IFA were demonstrated with dogs experimentally infected with E. canis, in which antibodies were detected as much as 2 weeks earlier, on day 14 postinoculation. gp36 and gp19 were not cross-reactive with antibodies in sera from E. chaffeensis-infected dogs and thus provided species-specific serologic discrimination between E. canis and E. chaffeensis infections. This is the first demonstration of the improved detection capability of the recombinant protein technology compared to the capability of the "gold standard" IFA and may eliminate the remaining obstacles associated with the immunodiagnosis of E. canis infections, including species-specific identification and the lack of sensitivity associated with low antibody titers early in the acute phase of the infection.