gebhart/patrepeval huggingface dataset:
Identification of MicroRNA Markers of Sensitivity to the Novel Bruton’s Tyrosine Kinase (BTK) Inhibitor PCI-32765 in Non-Hodgkin’s Lymphoma. (2008)

Abstract PCI-32765 is a novel, first-in-class small molecule inhibitor of Bruton’s tyrosine kinase (BTK), currently in preclinical development and shortly entering Phase I clinical trials for the treatment of hematological malignancies. BTK is essential in B-cells for signalling via the B-cell receptor (BCR), and mutations in BTK have been shown to cause x-linked agammaglobulinemia in humans and x-linked immunodeficiency (xid) in mice. We have found that PCI-32765 has demostrated significant growth inhibitory activity in vitro in a number of non-Hodgkin’s lymphoma (NHL) cell lines as well as primary human NHL tumors cultivated ex-vivo. However, certain subsets of NHL cell lines were found to respond better to the inhibitor, and in keeping with this, a wide variance was also observed in the response among primary human tumors. PCI-32765 had GI50 <3uM in 7/15 cell lines (46%), including 3 follicular lymphoma (FL) and 3 diffuse large B-cell lymphoma (DLBCL) lines. Based on these results, we tested primary tumors including 15 FL and 7 DLBCL, utilizing a modified version of Oncotech’s EDR Assay. We found that while only 1 of the DLBCL tumors showed a similar response, PCI-32765 had a response rate of 40% in the primary FL samples. The reasons for this variation are still under investigation but one reason may be that that not all tumors are equally dependent on BTK activation for their survival. In order to obtain a predictive marker for response to PCI-32765 in human tumors, we utilized a microRNA (miRNA) profiling approach in the primary FL tumors using a commercially available miRNA array platform. We hypothesized that miRNA might be a better diagnostic tool than mRNA because miRNA function is more conserved and it is more stable than mRNA (thus easier to harvest successfully from paraffin embedded blocks). Further, it has been shown that miRNA signatures can predict responsive and resistant phenotypes based on basal miRNA levels, and have been found to have essential functions in lymphomas. When the miRNA profiles from the FL tumors were analyzed, we found that a signature consisting of 4 miRNAs could predict the sensitive tumors with a p-value <0.01. Of these, 2 were upregulated and 2 were downregulated in the sensitive samples compared to the resistant ones. It is likely therefore that these are implicated in the mechansisms of sensitivity and resistance to PCI-32765 in the FL tumors, and the connections between genes regulated by these miRNAs to pathways controlled by BTK are being explored.
Canonical Nuclear Factor κB Pathway Links Tumorigenesis of Synchronous Mantle-Cell Lymphoma, Clear-Cell Renal-Cell Carcinoma, and GI Stromal Tumor (2011)

A 74-year-old man was admitted to National Taiwan University Hospital (Taipei, Taiwan) complaining of a 1-week history of abdominal pain and night sweats. The patient had no diarrhea or vomiting, but was hypotensive. An abdominal computed tomography (CT) scan revealed hemoperitoneum and a ruptured spleen. Laboratory results revealed elevated lactate dehydrogenase (1,256 U/L), WBC of 9.28 K/L, RBC of 3.67 M/L, a hemoglobin level of 11.2 g/dL, and a platelet count of 412 K/L. The patient's prior medical history was unremarkable, but one of the patient's daughters was reported to suffer from lupus. From a clinical standpoint, a spleen rupture as a result of splenomegaly (1,260 g) indicated surgery. In the course of a laparotomy, a 0.4-cm gastric serosal tumor and a 4-cm renal tumor at the upper right pole of the kidney were revealed. Lymphadenopathies in the bilateral supraclavicular, mediastinal, and abdominal regions, as well as in the junction of the cystic duct, common bile duct, and group 13 lymph nodes were noted.
Brand Management Through Narrowing the Gap Between Brand Identity and Brand Reputation (1999)

Abstract Classical models of brand management pay insufficient attention to staff as brand builders, placing more emphasis on external issues such as image. This paper explores the significant contribution from employees and considers the need to align their values and behaviours with the brand's desired values. It clarifies the importance of culture in brand building and discusses how an adaptive, strategically appropriate culture, consistently apparent throughout an organisation is likely to be associated with healthy brand performance. A model is proposed, suggesting that stronger brands result from a homogeneous brand identity, with congruent identity components. It argues that reputation is a more appropriate external assessment of a brand than image. By auditing the gaps between brand identity and brand reputation, managers can identify strategies to minimize incongruency and develop more powerful brands. It is concluded that brand reality is an important aspect of branding.
Surgical navigation with QR codes (2016)

Abstract The presented work is an alternative to established measurement systems in surgical navigation. The system is based on camera based tracking of QR code markers. The application uses a single video camera, integrated in a surgical lamp, that captures the QR markers attached to surgical instruments and to the patient.
Synthetic Route for the Preparation of 2-Hydroxy-<i>N</i>-[1-(2-hydroxyphenylamino)-1-oxoalkan-2-yl]benzamides (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTSynthetic Route for the Preparation of 2-Hydroxy-N-[1-(2-hydroxyphenylamino)-1-oxoalkan-2-yl]benzamidesAleš Imramovský*†, Juana M. Férriz‡, Karel Pauk†, Martin Krátký‡, and Jarmila Vinšová‡View Author Information Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, 532 10 Pardubice, the Czech Republic, and Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, the Czech Republic* To whom correspondence should be addressed. E-mail: [email protected]. Phone: +420 466037739. Fax: +420 466038004.†University of Pardubice.‡Charles University.Cite this: J. Comb. Chem. 2010, 12, 4, 414–416Publication Date (Web):April 30, 2010Publication History Received26 October 2009Published online30 April 2010Published inissue 12 July 2010https://pubs.acs.org/doi/10.1021/cc900168shttps://doi.org/10.1021/cc900168sbrief-reportACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views655Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical synthesis,Monomers,Organic compounds,Peptides and proteins,Rearrangement Get e-Alerts
Emission of Methane from Stainless Steel Surface Investigated by Using Tritium as a Radioactive Tracer (2006)

Abstract Gas-phase methane contamination caused from stainless steel (SS) surface by metal–metal friction was investigated by introducing tritium as a tracer of hydrogen atom in the metal surface. The emissions of HT, CH3T, and CH4 were measured by radio-gas-chromatography, and the SS canister containing many small SS balls inside was shaken to reproduce the metal–metal friction. The results indicate that the oxide layer on SS surface is controlling the emission of methane.
Management of psoriasis in pregnancy (2013)

Psoriasis is an inflammatory skin disorder not uncommonly seen in pregnant patients. Several drugs have been approved for its treatment in non-pregnant patients, but special precautions are necessary when selecting a treatment plan during pregnancy to prevent harm to the fetus and child. This article reviews the treatment options for the treatment of psoriasis in the pregnant and lactating patient.
Magnesium Thiodialkanoates: Dually-Functional Additives to Organic Coatings (2018)

Magnesium salts can enhance corrosion-protective properties of organic coatings. Here, mirocrystalline magnesium thiodipropionate (MgTDPA) and amorphous magnesium acetate thiodipropionate (MgAcTDPA) are synthesized in water via replacement and metathesis reactions, respectively, from 3,3′-thiodipropionic acid (TDPA), a nontoxic, film-forming dicarboxylic acid. The ability of the uncovered magnesium thiodipropionates to accelerate ring-opening polymerization of benzoxazines such as the aniline derivative of bisphenol and curing of the epoxy resin-amine hardener is confirmed using differential scanning calorimetry and rheological methods. The corrosion inhibition of galvanized steel by magnesium thiodipropionates was investigated by potentiodynamic polarization and electrochemical impedance spectroscopy measurements. Adsorption of TDPA anions on the galvanized steel surface followed the Langmuir adsorption isotherm. Epoxy-amine powder compositions containing MgTDPA were designed and coated on galvanized steel by electrodeposition, and performance of magnesium thiodipropionate as a delamination inhibitor was investigated by immersion and salt-spray cyclical tests. The widening of cuts in the coating (scribe creep) results demonstrated the dramatic protective action of magnesium thiodipropionate in the epoxy-amine powder coatings. Magnesium thiodipropionates appear to be economical and functional additives to organic coatings, aiding in curing and corrosion protection.
Talc poudrage versus talc slurry in the treatment of malignant pleural effusion. (2006)

Our study confirms that intrapleural talc carries good results in the treatment of malignant pleural effusion. TP was significantly more effective than TS; both methods were safe but TS had a higher incidence of thoracic pain during the procedure. Talc pleurodesis should be offered to every patient with MPE, apart from terminally ill ones, provided that a satisfying lung re-expansion has been achieved. TP should be performed whenever possible; otherwise, a slurry bedside procedure will be worthwhile, even in patients with low performance status (PS), though poorer results have to be expected. A careful selection is essential to define the proper technique.
Electrical and optical integration of a monolithic 1×12 array of InGaAsP/InP (λ=1.3-µm) light-emitting diodes (1985)

With high-volume data traffic increasing, the need for arrays of sources and detectors becomes apparent. We have developed a monolithically integrated 1×12 array of individually addressable surface-emitting LEDs which are mounted on a Si fanout. Heat is dissipated by a copper block in a DIP package.
ChemInform Abstract: A Vision for Vaccines Built from Fully Synthetic Tumor‐Associated Antigens: From the Laboratory to the Clinic (2013)

Abstract Review: 74 refs.
Changes in Spawning Runs of Sea Lamprey (<i>Petromyzon marinus</i>) in Selected Streams of Lake Superior after Chemical Control (1980)

During lampricide treatment of a stream, sea lamprey, Petromyzon marinus, that will constitute the spawning run the following spring inhabit the Great Lakes and are not affected by the treatment. However, the number of adults captured at electrical barriers declined as much as 99% in some streams 1 year after chemical treatment. Large declines of adults were noted in streams which were treated late in the year. Streams in which significant populations of larval lampreys survived the chemical treatment, or contained lentic populations, continued to attract adults. Adult sea lampreys could be attracted to sea lamprey ammocoetes in streams or in offshore areas and hence use this as one of a number of clues to determine rivers suitable for spawning.Key words: sea lamprey, olfaction, orientation/homing, spawning migration, habitat alteration (chemical), Petromyzon marinus, lampricides
RETRACTED: The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models (2019)

Therapies against glioblastoma (GBM) show a high percentage of failure associated with the survival of glioma stem cells (GSCs) that repopulate treated tumours. Forced differentiation of GSCs is a promising new approach in cancer treatment. Erythropoietin-producing hepatocellular (Eph) receptors drive tumourigenicity and stemness in GBM. We tested GLPG1790, a first small molecule with inhibition activity versus inhibitor of various Eph receptor kinases, in preclinical GBM models using in vitro and in vivo assays. GLPG1790 rapidly and persistently inhibited Ephrin-A1-mediated phosphorylation of Tyr<sup>588</sup> and Ser<sup>897</sup>, completely blocking EphA2 receptor signalling. Similarly, this compound blocks the ephrin B2-mediated EphA3 and EphB4 tyrosine phosphorylation. This resulted in anti-glioma effects. GLPG1790 down-modulated the expression of mesenchymal markers CD44, Sox2, nestin, octamer-binding transcription factor 3/4 (Oct3/4), Nanog, CD90, and CD105, and up-regulated that of glial fibrillary acidic protein (GFAP) and pro-neural/neuronal markers, βIII tubulin, and neurofilaments. GLPG1790 reduced tumour growth in vivo. These effects were larger compared to radiation therapy (RT; U251 and T98G xenografts) and smaller than those of temozolomide (TMZ; U251 and U87MG cell models). By contrast, GLPG1790 showed effects that were higher than Radiotherapy (RT) and similar to Temozolomide (TMZ) in orthotopic U87MG and CSCs-5 models in terms of disease-free survival (DFS) and overall survival (OS). Further experiments were necessary to study possible interactions with radio- and chemotherapy. GLPG1790 demonstrated anti-tumor effects regulating both the differentiative status of Glioma Initiating Cells (GICs) and the quality of tumor microenvironment, translating into efficacy in aggressive GBM mouse models. Significant common molecular targets to radio and chemo therapy supported the combination use of GLPG1790 in ameliorative antiglioma therapy.
Synthesis of pyrazolo[1,5-a]quinoxalin-4(5H)-ones via one-pot amidation/N-arylation reactions under transition metal-free conditions (2016)

An efficient one-pot transition metal-free procedure for the synthesis of new pyrazolo[1,5-a]quinoxalin-4(5H)-ones from easily prepared 1-(2-chlorophenyl-5-ethylcarboxylate)pyrazoles and various primary alkylamines is described. The key steps involved in the synthesis of the new 5,6-fused ring system are the formation of an amide intermediate followed by an intramolecular N-arylation reaction via nucleophilic aromatic substitution.
Physical Solubility of Carbon Dioxide in Aqueous Alkanolamines via Nitrous Oxide Analogy (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhysical Solubility of Carbon Dioxide in Aqueous Alkanolamines via Nitrous Oxide AnalogyGregory J. Browning and Ralph H. WeilandCite this: J. Chem. Eng. Data 1994, 39, 4, 817–822Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/je00016a040https://doi.org/10.1021/je00016a040research-articleACS PublicationsRequest reuse permissionsArticle Views1080Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A V-Shaped PM Vernier Motor With Enhanced Flux-Modulated Effect and Low Torque Ripple (2018)

This paper proposes a new V-shaped permanent magnet vernier (V-PMV) motor for potential applications in direct-drive system. By utilizing the V-shaped PM topology and suitable pole-slot ratio, not only the flux leakage can be reduced effectively which is inevitable in traditional surface-mounted and spoke-type vernier permanent magnet (VPM) motor, but also the utilization of air-gap magnetic field harmonics can be improved. Moreover, dummy slots are employed on the inner edge of rotor, so that the torque ripple can be reduced. To fairly estimate electromagnetic performances of the proposed V-PMV motor, an existing flux-concentrating VPM motor is selected purposely and designed with the same size for comparative analysis by using the finite-element method. The simulation results indicate that the V-PMV motor can offer the advantages of high PM utilization, and low cogging torque and torque ripple.
As Tecnologias de Informacao e Comunicacao na Formacao Inicial de Professores: uma Pratica Educativa na Escola Superior de Educacao Joao de Deus. (2009)

Este trabajo tiene como finalidad principal: Conocer, descubrir, analizar y comprender los ambientes formativos e identificar estos u otros factores, tales como el papel atribuido al profesor, a la escuela y a la relacion que esta establece o promueve, a las experiencias escolares, que pueden explicar las diferencias de aprendizaje de los alumnos e identificar posibles situaciones de dificultades originados por la ocurrencia de fracaso escolar en este nivel de ensenanza. Para la consecucion de esta finalidad importa entender de que forma la formacion inicial de profesores, podra contribuir a una mayor (informacion en esta tematica del mundo tecnologico y global.
Bag-of-Features Representations for Offline Handwriting Recognition Applied to Arabic Script (2012)

Due to the great variabilities in human writing, unconstrained handwriting recognition is still considered an open research topic. Recent trends in computer vision, however, suggest that there is still potential for better recognition by improving feature representations. In this paper we focus on feature learning by estimating and applying a statistical bag-of-features model. These models are successfully used in image categorization and retrieval. The novelty here is the integration with a Hidden Markov Model (HMM) that we use for recognition. Our method is evaluated on the IFN/ENIT database consisting of images of handwritten Arabic town and village names.
Practical aspects of video data transfer to network storage using 802.11 wlan technology for low-end consumer digital cameras (2003)

The latest models of low-end consumer digital cameras have begun to support A/V streaming directly to memory card. This greatly enhances the utility of the camera to an end user. In this paper we investigate techniques to provide a similar data storage service from camera directly to a wireless (802.11 WLAN) network server. Based on the results of our investigations a server-side application prototype is implemented which can reliably handle up to 3 concurrent connections from client devices at QVGA MJPEG frame rates up to 20 fps.
Rhenium and Rhenium Compounds (2010)

Abstract Rhenium remains one of the least abundant elements, existing in nature only in trace amounts. The major commercial source of rhenium is still molybdenite as a by‐ or coproduct of porphyry copper ores but also in the sediment‐hosted copper ores of Dzhezkazgan where the mineral was designated Dzhezkazganite after the name of the area. In the past three years, production has begun from similar copper deposits in Poland. Rhenium oxides are released during the roasting of the molybdenite or processing of the copper ores and captured by wet scrubbing followed by chemical processing of the scrub liquors to recover the rhenium as ammonium perrhenate, which then can be reduced to pure metal or converted to other rhenium chemicals. The metal has many high temperature uses as a pure metal or as an alloy with the elements of molybdenum, tungsten, and nickel. Those uses include filaments in bulbs and mass spectrometers, in thermocouples, and in heating elements. Ammonium perrhenate and perrhenic acid are both used to produce petroleum and petrochemical catalysts. The greatest use today is in the production of rhenium bearing nickel‐based alloys for the production of aircraft and land‐based gas turbine blades to improve the heat resistance of those blades. The use has grown to the point of creating a deficit in availability. Consumption has exceeded production, causing an increase in price from the $1100/kg range a few years ago to as much as $1l,000/kg in early 2009. However, recovery from super alloy scrap and other recycling, as well as gas turbine engine makers reducing the level of rhenium in certain areas of the engines and eliminating it in others, has caused the price to fall back to the $6500/kg range. Rhenium forms a wide variety of compounds in oxidation states from −1 to +7. High oxidation state compounds are the most common, whereas the lower oxidation states are primarily metal carbonyls and derivatives. Polynuclear compounds that have strong metal‐metal bonds are plentiful. Very little is know about the toxicity of rhenium or its compounds primarily because they are available and are used in significantly smaller quantities than most other materials of commerce. There seems to be significant information available on the Internet concerning the experimental use of a radioactive isotope of rhenium, Re 186 HEDP (1,1 hydroxyethylidene diphosphate) to aid in the reduction of bone pain resulting from metastatic cancer.
Reactivity of primate sera to foamy virus Gag and Bet proteins (1994)

In order to establish criteria for the serodiagnosis of foamy virus infections we investigated the extent to which sera from infected individuals of human and primate origin react with structural and non-structural virus proteins in immunoblot assays. Using lysates from infected cells as the source of virus antigen, antibodies were preferentially detected against the Gag proteins and the non-structural Bet protein. Both the Gag precursor molecules of 70 and 74K apparent M(r) and the cytoplasmic 60K M(r) Bet protein were found to be phosphorylated, the latter being synthesized in large amounts in infected cells. Rabbit antiserum raised against recombinant human foamy virus (HFV) Gag major capsid protein cross-reacted with foamy viruses of chimpanzee, gorilla, orang-utan, rhesus monkey and African green monkey origin. This was reflected by a broad cross-reactivity of the respective monkey sera to the Gag proteins of the various foamy virus isolates. Cross-reactivity of antisera against the Bet protein was restricted to viruses from man and the great apes. Recombinant Gag and Bet proteins expressed in prokaryotes or in insect cells were readily recognized by foamy virus-positive primate sera. Screening serum samples from chimpanzees with HFV Gag and Bet proteins expressed by recombinant baculoviruses revealed that 18 out of 35 (52%) were positive for Gag antibodies. Of these, 13 (72%) showed antibodies against the Bet protein, indicating that Bet antigen is of value in serological screening for foamy virus infections.