gebhart/patrepeval huggingface dataset:
Recognizing engagement in human-robot interaction (2010)

Based on a study of the engagement process between humans, we have developed and implemented an initial computational model for recognizing engagement between a human and a humanoid robot. Our model contains recognizers for four types of connection events involving gesture and speech: directed gaze, mutual facial gaze, conversational adjacency pairs and backchannels. To facilitate integrating and experimenting with our model in a broad range of robot architectures, we have packaged it as a node in the open-source Robot Operating System (ROS) framework. We have conducted a preliminary validation of our computational model and implementation in a simple human-robot pointing game.
Extrapyramidal side effects and tolerability of risperidone: a review. (1994)

Although heretofore relatively unrecognized, SSDs are prevalent, often persist, and are associated with substantial morbidity in widows and widowers during the first 2 years of bereavement.
Nociceptors as chronic drivers of pain and hyperreflexia after spinal cord injury: an adaptive-maladaptive hyperfunctional state hypothesis (2012)

Spinal cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent generation of spontaneous action potentials (SA) in peripheral branches and the somata of hyperexcitable nociceptors within dorsal root ganglia (DRG). Here it is proposed that SCI triggers in numerous nociceptors a persistent hyperfunctional state (peripheral, synaptic, and somal) that originally evolved as an adaptive response to compensate for loss of sensory terminals after severe but survivable peripheral injury. In this hypothesis, nociceptor somata monitor the status of their own receptive field and the rest of the body by integrating signals received by their peripheral and central branches and the soma itself. A nociceptor switches into a potentially permanent hyperfunctional state when central neural, glial, and inflammatory signal combinations are detected that indicate extensive peripheral injury. Similar signal combinations are produced by SCI and disseminated widely to uninjured as well as injured nociceptors. This paper focuses on the uninjured nociceptors that are altered by SCI. Enhanced activity generated in below-level nociceptors promotes below-level central sensitization, somatic and autonomic hyperreflexia, and visceral dysfunction. If sufficient ascending fibers survive, enhanced activity in below-level nociceptors contributes to below-level pain. Nociceptor activity generated above the injury level contributes to at- and above-level sensitization and pain (evoked and spontaneous). Thus, SCI triggers a potent nociceptor state that may have been adaptive (from an evolutionary perspective) after severe peripheral injury but is maladaptive after SCI. Evidence that hyperfunctional nociceptors make large contributions to behavioral hypersensitivity after SCI suggests that nociceptor-specific ion channels required for nociceptor SA and hypersensitivity offer promising targets for treating chronic pain and hyperreflexia after SCI.
The Spatial Cognitive Meaning of Across (2021)

Spatial relation is a basic existent relation in the objective world, and in English, prepositions are the important spatial terms to describe spatial relations people perceive. Using Langacker&rsquo;s trajector-landmark theory from cognitive grammar, this paper attempts to analyze the cognitive process of the six main spatial meaning of English preposition across based on the entries collected by the Collins Dictionary, with data from the the Leeds Collection of Internet Corpora. The findings can be concluded: (1) The use of across should include at least a tr and a lm, and the lm cannot be covert. (2) The spatial relations across contains could be divided into simple atemporal relation and complex atemporal relation. (3) The tr in some dynamic relation of across sometimes will represent some kind of schema, such as source-path-goal schema.
PRR7 protein levels are regulated by light and the circadian clock in Arabidopsis (2007)

Interlocking transcriptional loops and regulated protein degradation are the principal mechanisms involved in the generation of self-sustaining circadian rhythms in many organisms. In Arabidopsis the first proposed regulatory transcriptional loop involved the transcription factors CIRCADIAN CLOCK ASSOCIATED (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) and the pseudo-response regulator TIMING OF CHLOROPHYLL A/B BINDING PROTEIN (TOC1/PRR1). Recent findings indicate that the TOC1 homologues PRR7 and PRR9 might also be involved in transcriptional regulatory loops with CCA1 and LHY. In this study we show that the overexpression of PRR7 in Arabidopsis leads to severely compromised circadian rhythms. These transgenic lines display significantly reduced levels of CCA1 and LHY RNA, providing further evidence for a transcriptional feedback loop between PRR7 and these transcription factors. In addition, we show that the PRR7 protein is phosphorylated in a circadian regulated manner and that its levels are post-translationally regulated by both diurnal and circadian mechanisms. The Arabidopsis circadian oscillator is therefore likely to be entrained to light/dark cycles both through transcriptional and post-transcriptional mechanisms.
Gas hydrate formation rates from dissolved‐phase methane in porous laboratory specimens (2013)

Abstract Marine sands highly saturated with gas hydrates are potential energy resources, likely forming from methane dissolved in pore water. Laboratory fabrication of gas hydrate‐bearing sands formed from dissolved‐phase methane usually requires 1–2 months to attain the high hydrate saturations characteristic of naturally occurring energy resource targets. A series of gas hydrate formation tests, in which methane‐supersaturated water circulates through 100, 240, and 200,000 cm 3 vessels containing glass beads or unconsolidated sand, show that the rate‐limiting step is dissolving gaseous‐phase methane into the circulating water to form methane‐supersaturated fluid. This implies that laboratory and natural hydrate formation rates are primarily limited by methane availability. Developing effective techniques for dissolving gaseous methane into water will increase formation rates above our observed (1 ± 0.5) × 10 −7 mol of methane consumed for hydrate formation per minute per cubic centimeter of pore space, which corresponds to a hydrate saturation increase of 2 ± 1% per day, regardless of specimen size.
EXTRACORPOREAL LIVER PERFUSION USING HUMAN AND PIG LIVERS FOR ACUTE LIVER FAILURE (2000)

These data demonstrate that ECLP is safe and can provide metabolic support for comatose patients with fulminant hepatic failure for up to 5 days. While labor and resource intensive, this technology is available to centers caring for patients with acute liver failure and deserves wider evaluation and application.
Microemulsion Polymerization. 3. Molecular Weight and Particle Size Distributions (2001)

Molecular weight and particle size distributions of latexes prepared by free radical polymerization of n-butyl methacrylate, tert-butyl methacrylate, n-hexyl methacrylate, and styrene in aqueous microemulsions of dodecyltrimethylammonium bromide surfactant are measured using GPC/MALLS, QLS, and cryo-TEM. The results are compared to a molecular weight distribution model derived from the monomer partitioning and kinetic studies described in the accompanying papers. Polystyrene with weight-average molecular weights of ∼15 × 106 Da, which are 7 times greater than the limiting molecular weight imposed by chain transfer to monomer, are consistently obtained. Diffusion-limited exit of monomer radicals, generated by chain transfer, to the aqueous phase coupled with chain transfer to polymer are likely reasons for the enhanced polystyrene molecular weights.
Catalytic Effect of Nanogold on Cu(II)−N<sub>2</sub>H<sub>4</sub> Reaction and Its Application to Resonance Scattering Immunoassay (2008)

In the medium of EDTA-NaOH, nanogold strongly catalyzed the slow reaction between hydrazine (N2H4) and Cu(II) to form Cu particles, which exhibited a strong resonance scattering (RS) peak at 602 nm. The increased RS intensity at 602 nm (DeltaI(RS)) was linear to the nanogold concentration in the range of 0.008-2.64 nM, with a detection limit of 1.0 pM Au. The rate equation obtained by the initial rate procedure was V(Cu) = K(Cu)[C(Cu(II))](2)C(OH)(1)C(Au)(1)C(N2)H4(1), with an apparent activation energy of 38 kJ x mol(-1), and the catalytic reaction mechanism was also discussed. An immunonanogold-catalytic resonance scattering spectral (RSS) assay was established for detection of microalbumin (Malb), using 10 nm nanogold to label goat antihuman Malb to obtain an immunonanogold probe (AuMalb) for Malb. In pH 5.0 citric acid-Na2HPO4 buffer solution, the AuMalb aggregated nonspecifically. Upon addition of Malb, it reacted with the probe to form dispersive AuMalb-Malb immunocomplex in the solution. After centrifugation, the supernatant containing AuMalb-Malb was obtained, and exhibited a catalytic effect on the reaction of N2H4-Cu(II) to produce large Cu particles that resulted in the I(602 nm) increasing. The increased RS intensity at 602 nm (DeltaI(602 nm)) was linear to Malb concentration (C(Malb)) in the range of 0.4 to 460 pg x mL(-1), with the regression equation of DeltaI(602 nm) = 0.3713 C(Malb) + 7.2, correlation coefficient of 0.9981 and detection limit of 0.1 pg x mL(-1) Malb. The proposed method was applied to detect Malb in healthy human urine samples, with satisfactory results.
Effect of noscapine, the antitussive opioid alkaloid, on bradykinin-induced smooth muscle contraction in the isolated ileum of the guinea-pig (2001)

Bradykinin (BK) and related kinins are autocoid peptides that play integral roles in many pathophysiological processes such as cough. In this study, the inhibitory effect of noscapine, the antitussive opioid alkaloid, on BK receptors, was tested in the guinea-pig ileum. Contractions of the isolated ileum of the guinea-pig in response to BK were inhibited by noscapine (10-1,000 nM) in a concentration-dependent manner. Concentration-response curves (CRCs) to BK were slightly shifted to the right with a concomitant decrease in the maximum effect. A pA2 value of 6.68 was calculated for noscapine. The slope of the Schild plot of the antagonism was found to be 0.56. Noscapine had no effect on contractions induced by KCl, acetylcholine, histamine, 5-hydroxy tryptamine or angiotensin II. In conclusion, noscapine has a specific antagonistic effect on BK receptors and the mode of inhibition was found to be non-competitive.
Mobile Phones as Traffic Probes: Practices, Prospects and Issues (2006)

Abstract The provision of road‐based travel‐time information often relies on speed data collected from inductive loops imbedded in the pavement. While inductive loops are commonly installed on urban freeways, they are neither configured nor ideally located to provide speed data on arterial roads. Dissemination of dynamic, network‐wide travel information to road users is, therefore, likely to require alternative data collection techniques. This review considers the state of practice in relation to using mobile phones as traffic probes, assesses the prospects for this data collection option and identifies unresolved issues that may have implications for obtaining real‐time traffic information using mobile phones as probes. The use of mobile phones as traffic probes is appealing because the necessary infrastructure is already in place in most urban areas. Traffic speed information can be obtained by passively monitoring data transmission in the mobile phone network. International experience provides encouraging signs about the potential of mobile phones as traffic probes. Issues still to be resolved include potential public concerns about privacy, growing awareness of the road safety implications of mobile phone use and the need to understand better the quality of the data obtained from mobile phone probes.
Inflammasomes in the urinary tract: a disease-based review (2016)

Inflammasomes are supramolecular structures that sense molecular patterns from pathogenic organisms or damaged cells and trigger an innate immune response, most commonly through production of the proinflammatory cytokines IL-1β and IL-18, but also through less understood mechanisms independent of these cytokines. Great strides have been made in understanding these structures and their dysfunction in various inflammatory diseases, lending new insights into urological and renal problems. From a clinical perspective, benign urinary pathology almost universally involves the inflammatory process, and understanding how inflammasomes translate etiological conditions (diabetes, obstruction, stones, urinary tract infections, etc.) into acute and chronic inflammatory responses is critical to understanding these diseases at a molecular level. To date, inflammasome components have been found in the bladder, prostate, and kidney and have been shown to be activated in response to several infectious and noninfectious insults. In this review, we summarize what is known regarding inflammasomes in both the upper and lower urinary tract and describe several common disease states where they potentially play critical roles.
A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal (2012)

Throughout life, intestinal Lgr5+ stem cells give rise to proliferating transient amplifying cells in crypts, which subsequently differentiate into one of the five main cell types and migrate along the crypt-villus axis. These dynamic processes are coordinated by a relatively small number of evolutionarily conserved signaling pathways, which includes the Wnt signaling pathway. The DNA-binding proteins of the T-cell factor family, Tcf1/Tcf7, Lef, Tcf3/Tcf7l1, and Tcf4/Tcf7l2, constitute the downstream effectors of the Wnt signaling pathway. While Tcf4 is the major member active during embryogenesis, the role of these Wnt effectors in the homeostasis of the adult mouse intestinal epithelium is unresolved. Using Tcf1-/-, Tcf3(flox), and novel Tcf4(flox) mice, we demonstrate an essential role for Tcf4 during homeostasis of the adult mouse intestine.
An Enhanced Density Based Spatial Clustering of Applications with Noise (2009)

DBSCAN is a pioneer density based clustering algorithm. It can find out the clusters of different shapes and sizes from the large amount of data which is containing noise and outliers. But the clusters detected by it contain large amount of density variation within them. It can not handle the local density variation that exists within the cluster. For good clustering a significant density variation may be allowed within the cluster because if we go for homogeneous clustering, a large number of smaller unimportant clusters may be generated. In this paper we propose an Enhanced DBSCAN algorithm which keeps track of local density variation within the cluster. It calculates the density variance for any core object with respect to its e -neighborhood. If density variance of a core object is less than or equal to a threshold value and also satisfying the homogeneity index with respect to its e -neighborhood then it will allow the core object for expansion. The experimental results show that the proposed clustering algorithm gives optimized results.
Effect by acupuncture on hypothalamic expression of maternally separated rats: proteomic approach (2009)

The result suggests that acupuncture to HT8 may affect neurodevelopment, and acupuncture may be a possible therapy for neurodevelopmental disorders.
Immunosuppression mediated by an inhibitor of S-adenosyl-L-homocysteine hydrolase. Prevention and treatment of collagen-induced arthritis. (1993)

The potent irreversible inhibitor of S-adenosyl-L-homocysteine hydrolase (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (MDL 28,842) was examined for its effect on the development and treatment of collagen-induced arthritis in mice. We have previously shown that MDL 28,842 inhibits T cell activation without affecting B cell activation. Animals were dosed with MDL 28,842 at 5, 2.5, or 1 mg/kg/day p.o. in water beginning 1 day before immunization with chick type II collagen (CII) and continuing through day 51 postimmunization. None of the animals treated with MDL 28,842 at 5 or 2.5 mg/kg/day developed arthritis compared with 87.5% of the controls. Animals treated with 1 mg/kg MDL 28,842 had a delay in the development of the disease and a decreased incidence of arthritis (55%) during the course of treatment. After the treatment was discontinued, 40% of the mice in the 5-mg/kg treatment group, 60% of the mice who had previously received 2.5 mg/kg MDL 28,842, and 27% of the mice in the 1-mg/kg treatment group remained free of any signs of arthritis. Treatment with MDL 28,842 also lowered serum anti-CII IgG levels. In addition, T cells taken from animals immunized with CII and treated with 2.5-mg/kg/day MDL 28,842 had a lower proliferative response to denatured CII in vitro than controls. Therapeutically, MDL 28,842 was administered to animals at 2.5 mg/kg/day p.o., beginning at the first clinical signs of arthritis and continuing for 4 wk. Over the course of treatment, there was significantly less clinical disease in animals given MDL 28,842. In addition, at the end of treatment, hind paws were removed from the animals and examined radiographically and histologically for joint pathology. Animals treated with MDL 28,842 had significantly fewer bone lesions than control animals. These results suggest that inhibitors of S-adenosyl-L-homocysteine hydrolase may be effective anti-arthritic agents.
Recasting Gradient-Based Meta-Learning as Hierarchical Bayes (2018)

Meta-learning allows an intelligent agent to leverage prior learning episodes as a basis for quickly improving performance on a novel task. Bayesian hierarchical modeling provides a theoretical framework for formalizing meta-learning as inference for a set of parameters that are shared across tasks. Here, we reformulate the model-agnostic meta-learning algorithm (MAML) of Finn et al. (2017) as a method for probabilistic inference in a hierarchical Bayesian model. In contrast to prior methods for meta-learning via hierarchical Bayes, MAML is naturally applicable to complex function approximators through its use of a scalable gradient descent procedure for posterior inference. Furthermore, the identification of MAML as hierarchical Bayes provides a way to understand the algorithm's operation as a meta-learning procedure, as well as an opportunity to make use of computational strategies for efficient inference. We use this opportunity to propose an improvement to the MAML algorithm that makes use of techniques from approximate inference and curvature estimation.
Three-Point Dixon Chemical-Shift Imaging for Evaluating Articular Cartilage Defects in the Knee Joint on a Low-Field-Strength Open Magnet (2001)

The modified three-point Dixon sequence is a useful technique for achieving fat suppression in the knee joint on a 0.35-T open magnet. It is a sensitive and specific technique for the assessment of cartilage abnormalities in the knee.
Improved statistical tests for differential gene expression by shrinking variance components estimates (2004)

Combining information across genes in the statistical analysis of microarray data is desirable because of the relatively small number of data points obtained for each individual gene. Here we develop an estimator of the error variance that can borrow information across genes using the James-Stein shrinkage concept. A new test statistic (FS) is constructed using this estimator. The new statistic is compared with other statistics used to test for differential expression: the gene-specific F test (F1), the pooled-variance F statistic (F3), a hybrid statistic (F2) that uses the average of the individual and pooled variances, the regularized t-statistic, the posterior odds statistic B, and the SAM t-test. The FS-test shows best or nearly best power for detecting differentially expressed genes over a wide range of simulated data in which the variance components associated with individual genes are either homogeneous or heterogeneous. Thus FS provides a powerful and robust approach to test differential expression of genes that utilizes information not available in individual gene testing approaches and does not suffer from biases of the pooled variance approach.
Giant Vesicles Containing Magnetic Nanoparticles and Quantum Dots: Feasibility and Tracking by Fiber Confocal Fluorescence Microscopy (2007)

Hybrid vesicles: Magnetic nanoparticles (γ-Fe2O3) and quantum dots (CdSe/ZnS) can be entrapped in stable vesicles by emulsion processes. The hybrid vesicles (HVs) have distinct magnetic and fluorescence properties (see images; scale bars: 10 μm). Fluorescence detection allows magnetic manipulation and tracking of the HVs in vivo by both magnetic resonance and fluorescence imaging. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700581_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A quantitative study of the reinnervation of the goldfish optic tectum following optic nerve crush (1982)

Stereological and quantitative morphometric methods were used to study changes in the stratum fibrosum et griseum superficialis (SFGS), the major retinal target, in optic tectum of goldfish, during regeneration of the optic nerve. Orthograde transport of HRP by optic axons was used to characterize the retinal projection in SFGS. Profiles of HRP-labeled optic terminals contained rounded vesicles, contacted small dendrites, and were distributed uniformly throughout the area of SFGS sampled; labeling density estimates indicate that at least 37% of the total terminal population in SFGS is retinal in origin. Partial denervation of the tectum by optic nerve crush is accompanied by a loss of 40% of the total terminal population in SFGS and by a marked decrease of SFGS thickness. Entry of massive numbers of regenerating optic axons into SFGS begins about 3 weeks postoperatively, about the time that some visual function recovers and produces a marked increase in SFGS thickness which persists for several months postoperatively. The area occupied by regenerating axons and the number of terminals in the tectum only approach preoperative levels 3 months postoperatively. The recovery of normal synaptic number is therefore delayed several months beyond the time of entry of regenerative axonal sprouts. The results indicate that return of synaptic number to normal is temporally associated with the reduction of the excess number of regenerating optic axons and that both these processes are prolonged.