gebhart/patrepeval huggingface dataset:
DIEZ POR CIENTO DE LOS MEXICANOS RONCA O PADECE INSOMNIO CRÓNICO (2007)

TERCERA PARTE DE POBLACION MEXICANA PRESENTA ALGUN TRASTORNO DEL SUENO Y 10 POR CIENTO INSOMNIO Y RONQUIDO CRONICOS; TAN SOLO ESTE ULTIMO PODRIA DERIVAR EN UN INFARTO, EMBOLIA O ENFERMEDAD DE TIPO CARDIACA O CEREBRO-VASCULAR, ASEGURO REYES HARO VALENCIA, DIRECTOR DE CLINICA DE TRASTORNOS DEL SUENO DE UNAM. EL ESPECIALISTA CONSIDERO QUE AUN HAY QUIENES PIENSAN QUE RONCAR SIGNIFICA DORMIR BIEN Y PROFUNDAMENTE, PERO NO ES VERDAD, ES TODO LO CONTRARIO, ES UN AVISO DE QUE HAY UNA DIFICULTAD. ADVIRTIO QUE ALGUNAS PERSONAS DEJAN DE RESPIRAR UN CENTENAR DE OCASIONES EN CADA HORA DE SUENO Y ESTAS APNEAS A VECES LLEGAN A DURAR M S DE DOS MINUTOS Y, EN CONSECUENCIA, DISMINUCION EN LOS NIVELES DE OXIGENO MODIFICA EL FUNCIONAMIENTO DEL CORAZON EN TODO EL ORGANISMO Y ACTIVA UNA SENAL DE ALARMA, PORQUE DE NO REACCIONAR PARA VOLVER A RESPIRAR SUCUMBIRIA EL INDIVIDUO. TRAS ACLARAR QUE QUIEN RONCA CONSTANTEMENTE NO TIENE PELIGRO EN SU SALUD Y SOLO TENDRIA QUE VIGILAR NO SUBIR DE PESO, ASI COMO EVITAR EL ALCOHOL Y COMIDAS PESADAS POR NOCHE, RECOMENDO QUE QUIENES PRESENTAN PAUSAS RESPIRATORIAS, DENOMINADO SINDROME DE APNEA OBSTRUCTIVA DE SUENO (SAOS), DEBEN LLEVAR UN TRATAMIENTO MEDICO. CON CASI DOS DECADAS DE EXPERIENCIA EN PROBLEMAS DE SUENO, EL ESPECIALISTA INDICO QUE ESTE TRASTORNO, CASI SIEMPRE HEREDADO, CUANDO SE PRESENTA COMO DICHO SINDROME GENERA PRESION ALTA. LA HIPERTENSION ES EL PRIMER SIGNO DE QUE HAY UN RIESGO IMPORTANTE DE PROBLEMAS CARDIACOS O CEREBRO-VASCULARES EN UN RONCADOR. EXPLICO QUE SOLO SE MANIFIESTA DORMIDO, CUANDO SE RELAJAN LOS TEJIDOS DE BOCA Y ESTOS CRECEN DE MANERA ANORMAL, HAYA SOBREPESO O NO EN PERSONA Y SIN IMPORTAR SU POSICION. DETALLO QUE LAS ESTRUCTURAS BUCALES COMO LENGUA, ANGINAS Y PALADAR BLANDO SON MUSCULOS QUE CON EL PASO DEL AIRE PRODUCEN ESTA VIBRACION. INSISTIO EN QUE EL RONQUIDO SEGUIDO NO PRESENTA UN PROBLEMA MEDICO, PERO CUANDO OCURRE CON PAUSAS DE 15, 20, 60 O M S SEGUNDOS, ESE SILENCIO INDICA EL TIEMPO QUE SE EST  DEJANDO DE RESPIRAR. POR OTRA PARTE, HARO VALENCIA COMENTO QUE EL RONQUIDO, JUNTO CON EL INSOMNIO, SON LAS PATOLOGIAS ADULTAS M S ATENDIDAS EN CLINICAS DE TRASTORNOS DEL SUENO EN EL PAIS Y EL MUNDO. DE ACUERDO CON ESTADISTICAS, AFIRMO QUE ALREDEDOR DE 30 POR CIENTO DE LOS MEXICANOS HA PADECIDO INSOMNIO EN ALGUN MOMENTO DE SU VIDA Y 10 POR CIENTO DE ESTOS LO SUFREN DE MANERA CRONICA, MISMOS QUE LLEGAN A PERDER CUATRO HORAS O M S DE SUENO CADA NOCHE, SIENDO UNA DE LAS 20 CAUSAS DE ESTE TRASTORNO DEPENDENCIA AL USO CRONICO DE INDUCTORES. ASEVERO QUE HAY TRES TIPOS DE INSOMNES: QUIEN TARDA M S DE UNA HORA EN CONCILIAR EL SUENO AL ACOSTARSE, QUIEN DESPIERTA CONSTANTEMENTE DURANTE NOCHE, Y QUIEN SE LEVANTA EXCESIVAMENTE TEMPRANO, SIN PODER VOLVERSE A DORMIR. EXPUSO QUE LAS CAUSAS DEL INSOMNIO SON DIFERENTES ENTRE SI, MAYORIA PSICOFISIOLOGICAS, Y SU TRATAMIENTO TAMBIEN.
Clinical utility of testing AQP4-IgG in CSF (2016)

This study provides Class IV evidence that for patients with NMO or NMOSD, CSF is less sensitive than serum for detection of AQP4-IgG.
Institutional Theory, New (2018)

Abstract Although new institutional theory has turned into a widely accepted framework for actor‐centered studies dealing with organizations, state, and society, it lacks the qualities of a full‐fledged theory. Scholars refer to different disciplinary approaches and traditions in sociology, social psychology, economics, and political sciences with only a few common lines of argumentation. Nevertheless, new institutionalism offers a useful conceptual framework for organizational studies and for other fields in the social sciences, such as urban and regional studies or political studies. A clear problem of institutional theory is its simplified description of the way institutions work. Although many critical scholars see new institutionalism as a concept that is too abstract and too diverse to be directly translated into a clear analytical approach, new institutionalist research can open up a broad field for inductive investigations favoring a better understanding of how particular organizations work, focusing on issues of agency within specific institutional settings and constraints.
Music across the curriculum: Art & Design (2013)

In the penultimate article of the series, Elizabeth Hoad suggests ideas for developing creativity through both music and artwork, and for linking the two together.
Size-controllable synthesis of lithium niobate nanocrystals using modified Pechini polymeric precursor method (2016)

Nanopowders of lithium niobate (LiNbO3, LN) were synthesized by a water-based modified Pechini method, in which Li2CO3 and ammonium niobate (v) oxalate hydrate (C4H4NNbO9·xH2O) are used as the Li and Nb source materials, respectively. The kinetics of formation of the intermediate gelatinous precursor was studied by thermal gravimetry and differential scanning calorimetry. The LN nanoparticles produced by calcining of the gel at various temperatures were characterized by X-ray diffraction and scanning electron microscopy. The effect of the calcination temperature on the morphology and structure of LN nanoparticles produced is investigated. The particle and crystallite sizes of the LN prepared could be controlled in the range of 20–250 nm by changing the calcination temperature of the gelatinous precursor.
Shape-dependent electrocatalytic activity of free gold nanoparticles toward glucose oxidation (2013)

The synthesis of shape and size-controlled free gold nanoparticles (AuNPs) was achieved by wet chemical methods. The UV–vis spectroscopy measurements and transmission electron microscopy characterizations confirmed the fine distribution in size and shape of the AuNPs. The zeta potential measurements permitted the evaluation of the stability of the AuNPs suspension. For the first time, the shape dependence on the electrocatalytic activity of these NPs is thoroughly investigated. The underpotential deposition (UPD) of lead reveals that their crystallographic facets are affected by their shape and growth process. Moreover, the glucose oxidation reaction strongly depends on the shape of AuNPs. Indeed, the gold nanocuboids (GNCs) and the spherical gold nanoparticles (GNSs) are significantly more active than the gold nanorods (GNRs) followed by the polyhedrons (GNPs). The oxidation process occurs at low potential for GNCs whereas the current densities are slightly higher for GNSs electrodes. Most importantly, the control of the shape and structure of nanomaterials is of high technological interest because of the strong correlation between these parameters and their optical, electrical and electrocatalytic properties.
Research synthesis in the sport & exercise sciences: Introduction to the collection (2006)

Basic research synthesis, the bringing together for discussion of the results, findings and conclusions of previous studies, is part of almost every research project. Research starts with a survey ...
PLASMA CVD USING ORGANOMETALLIC COMPOUNDS (1989)

About 50 organometallic compounds have been tested as precursors in the plasma-enhanced chemical vapour deposition (PECVD) of metallic and oxidic films. The classes of compounds which are best suited for the deposition are described. Experimental techniques and problems are discussed. This paper besides briefly reviewing some of our earlier work, focusses on recent, unpublished.
Control of mouse myoblast commitment to terminal differentiation by mitogens (1980)

Regulation of the transition of mouse myoblasts from proliferation to terminal differentiation was studied with clonal density cultures of a permanent clonal myoblast cell line. In medium lacking mitogenic activity, mouse myoblasts withdraw from the cell cycle, elaborate muscle-specific gene products, and fuse to form multinucleated myotubes. Addition of a purified mitogen, fibroblast growth factor, to mitogen-depleted medium stimulates continued proliferation and prevents terminal differentiation. When mitogens are removed for increasing durations and then refed, mouse myoblasts irreversibly commit to terminal differentiation: after 2-4 h in the absence of mitogens, myoblasts withdraw from the cell cycle, elaborate muscle-specific gene products, fuse in the presence of mitogens that have been fed back. Population kinetics of commitment determined with 3H-thymidine labeling and autoradiography suggests the following cell-cycle model for mouse myoblast commitment: 1)if mitogens are present in the extracellular environment of myoblasts in G1 of the cell cycle, the cells enter S and continue through another cell cycle; 2) if mitogens have been absent for 2 or more hours, cells in G1 do not enter S; the cells commit to differentiate, permanently withdraw from the cell cycle (will not enter S if mitogens are refed), and they subsequently elaborate acetylcholine receptors and fuse (even if mitogens are refed); 3) cells in other phases of the cell cycle continue to transit the cell cycle in the absence of mitogens until reaching the next G1. the commitment kinetics and experiments with mitotically synchronized cells suggest that the commitment "decision" is made during G1. Present results do not, however, exclude commitment of some cells in other phases of the cell cycle.
Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial (2021)

We evaluated the safety and efficacy of fully closed-loop insulin therapy compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis. In an open-label, multinational, two-center, randomized crossover trial, 26 adults with type 2 diabetes requiring dialysis (17 men, 9 women, average age 68 ± 11 years (mean ± s.d.), diabetes duration of 20 ± 10 years) underwent two 20-day periods of unrestricted living, comparing the Cambridge fully closed-loop system using faster insulin aspart ('closed-loop') with standard insulin therapy and a masked continuous glucose monitor ('control') in random order. The primary endpoint was time in target glucose range (5.6-10.0 mmol l<sup>-1</sup>). Thirteen participants received closed-loop first and thirteen received control therapy first. The proportion of time in target glucose range (5.6-10.0 mmol l<sup>-1</sup>; primary endpoint) was 52.8 ± 12.5% with closed-loop versus 37.7 ± 20.5% with control; mean difference, 15.1 percentage points (95% CI 8.0-22.2; P < 0.001). Mean glucose was lower with closed-loop than control (10.1 ± 1.3 versus 11.6 ± 2.8 mmol l<sup>-1</sup>; P = 0.003). Time in hypoglycemia (<3.9 mmol l<sup>-1</sup>) was reduced with closed-loop versus control (median (IQR) 0.1 (0.0-0.4%) versus 0.2 (0.0-0.9%); P = 0.040). No severe hypoglycemia events occurred during the control period, whereas one severe hypoglycemic event occurred during the closed-loop period, but not during closed-loop operation. Fully closed-loop improved glucose control and reduced hypoglycemia compared with standard insulin therapy in adult outpatients with type 2 diabetes requiring dialysis. The trial registration number is NCT04025775.
Iodophenylpentadecanoic acid-myocardial blood flow relationship during maximal exercise with coronary occlusion. (1990)

Imaging 123I-labeled iodophenylpentadecanoic acid (IPPA) uptake and clearance from the myocardium following exercise has been advocated as a means of detecting myocardial ischemia because fatty acid deposition is enhanced and clearance prolonged in regions of low flow. However, normal regional myocardial blood flows are markedly heterogeneous, and it is not known how this heterogeneity affects regional metabolism or substrate uptake and thus image interpretation. In five instrumented dogs running at near maximal workload on a treadmill, 131I-labeled IPPA and 15-micron 46Sc microspheres were injected into the left atrium after 30 sec of circumflex coronary artery occlusion. Microsphere and IPPA activity were determined in 250 mapped pieces of myocardium of approximately 400 mg. Myocardial blood flows (from microspheres) ranged from 0.05 to 7.6 ml/min/g. Deposition of IPPA was proportional to regional flows (r = 0.83) with an average retention of 25%. The mean endocardial-epicardial ratio for IPPA (0.90 +/- 0.43) was similar to that for microspheres (0.94 +/- 0.47; p = 0.08). Thus, initial IPPA deposition during treadmill exercise increases in proportion to regional myocardial blood flow over a range of flows from very low to five times normal.
Expression of Intra-MHC Transporter ( <i>Ham</i> ) Genes and Class I Antigens in Diabetes-Susceptible NOD Mice (1992)

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Oxidative reforming of methane on structured Ni-Al2O3/cordierite catalysts (2012)

The catalytic properties of Ni/Al2O3 composites supported on ceramic cordierite honeycomb monoliths in oxidative methane reforming are reported. The prereduced catalyst has been tested in a flow reactor using reaction mixtures of the following compositions: in methane oxidation, 2–6% CH4, 2–9% O2, Ar; in carbon dioxide and oxidative carbon dioxide reforming of methane, 2–6% CH4, 6–12% CO2, and 0–4% O2, and Ar. Physicochemical studies include the monitoring of the formation and oxidation of carbon, the strength of the Ni-O bond, and the phase composition of the catalyst. The structured Ni-Al2O3 catalysts are much more productive in the carbon dioxide reforming of methane than conventional granular catalysts. The catalysts performance is made more stable by regulating the acid-base properties of their surface via the introduction of alkali metal (Na, K) oxides to retard the coking of the surface. Rare-earth metal oxides with a low redox potential (La2O3, CeO2) enhance the activity and stability of Ni-Al2O3/cordierite catalysts in the deep and partial oxidation and carbon dioxide reforming of methane. The carbon dioxide reforming of methane on the (NiO + La2O3 + Al2O3)/cordierite catalyst can be intensified by adding oxygen to the gas feed. This reduces the temperature necessary to reach a high methane conversion and does not exert any significant effect on the selectivity with respect to H2.
PROCESS DRYING PRACTICE (1992)

Using graphs, calculation models and step-by-step guidelines, the authors describe the important tools and techniques and explain how to use them to perform scale-ups and calculate exposure times, to test dryers and study the relationship between drying processes and dryer characteristics, to analyze psychometric charts, to utilize calculation methods for process drying any solvent in any gas, and to overcome complications in the start-up phase and troubleshoot the cause of low production in drying systems. The book presents equations for the solution of a wide range of problems encountered in process drying.
Design Considerations for Optimizing Storyline Visualizations (2012)

Storyline visualization is a technique used to depict the temporal dynamics of social interactions. This visualization technique was first introduced as a hand-drawn illustration in XKCD's "Movie Narrative Charts" [21]. If properly constructed, the visualization can convey both global trends and local interactions in the data. However, previous methods for automating storyline visualizations are overly simple, failing to achieve some of the essential principles practiced by professional illustrators. This paper presents a set of design considerations for generating aesthetically pleasing and legible storyline visualizations. Our layout algorithm is based on evolutionary computation, allowing us to effectively incorporate multiple objective functions. We show that the resulting visualizations have significantly improved aesthetics and legibility compared to existing techniques.
The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition (2007)

Therapeutic approaches that target more complete inhibition of the RAAS may offer additional clinical benefits for patients with cardiovascular and renal disorders. These approaches may include dual blockade using ACE Is and ARBs in combination, or new therapeutic modalities such as direct renin inhibition with aliskiren, recently approved for the treatment of hypertension.
Pilot Study of Hyperfractionated Dosing of Lutetium-177–Labeled Antiprostate-Specific Membrane Antigen Monoclonal Antibody J591 (177Lu-J591) for Metastatic Castration-Resistant Prostate Cancer (2020)

Hyperfractionation of <sup>177</sup> Lu-J591 is feasible but does not seem to have significant advantages over the two-dose fractionation regimen.
One-Dimensional Protein Analysis of an HT29 Human Colon Adenocarcinoma Cell (1999)

A single HT29 human colon adenocarcinoma cell was introduced into a fused-silica capillary and lysed, and the protein content was fluorescently labeled with the fluorogenic reagent 3-(2-furoyl)quinoline-2-carboxaldehyde. The labeled proteins were separated by capillary electrophoresis in a submicellar buffer and detected by laser-induced fluorescence in a postcolumn sheath-flow cuvette. Several dozen components were resolved. A number of experiments were done to verify that these components were proteins. Most components of the single-cell electropherogram had the same mobility as components present in the 30-100 kDa fraction of a protein extract prepared from the cell culture. One component was identified as a approximately 100 kDa protein by co-injecting the sample with purified protein obtained from an SDS-PAGE gel. Protein expression varied significantly between cells, but the average expression was consistent with that observed from a protein extract prepared from 10(6) cells.
Fluorescent Chemosensors as Future Tools for Cancer Biology (2018)

It is well established that aberrant cellular biochemical activity is strongly linked to the formation and progression of various cancers. Assays that could aid in cancer diagnostics, assessing anticancer drug resistance, and in the discovery of new anticancer drugs are highly warranted. In recent years, a large number of small molecule-based fluorescent chemosensors have been developed for monitoring the activity of enzymes and small biomolecular constituents. These probes have shown several advantages over traditional methods, such as the ability to directly and selectively measure activity of their targets within complex cellular environments. This review will summarize recently developed fluorescent chemosensors that have potential applications in the field of cancer biology.
Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells (2009)

A population of tolerogenic CD103+ DCs was identified in the human gut that probably differentiate in response to IEC-derived factors and drive T(reg) cell development.
Amalgam Substitutes: A Critical Analysis (2000)

All compomers showed a radiopacity of 2.5 mm or more aluminum. Only Dyract AP and Elan were more wear resistant than amalgam. After stressing, the percentage of continuous margin was at best 31% overall and 17% in dentin only. Among resin-based composites, the minimum requirements of radiopacity were fulfilled only by Alert, Surefil, and Tetric. Only Definite, Surefil, Solitaire, and Tetric exhibited wear resistance greater than amalgam. After stressing, the best marginal qualities were 41% continuous margin overall, and 8% in dentin only.
Rate distortion analysis of high dynamic range video coding techniques (2015)

High Dynamic Range (HDR) is a key technology envisioned to provide the end-users a sense of “being there”. With the advent of HDR displays in the near future, it is not clear if the existing content distribution environment will be capable of supporting HDR. Although it is generally argued that single-layer HDR coding solutions are superior to two-layer backward-compatible techniques, these coding strategies have not been fully investigated in terms of their rate distortion trade-off. In this paper, three main HDR coding techniques are implemented to analyze their performance and to evaluate the potential of HDR content distribution, while minimizing the impact on existing infrastructure, i.e., in terms of bitrate and HDR quality trade-off. The results reveal that backward-compatible solutions can outperform the single-layer approach achieving PSNR_DE improvements of up to 3.05dB on average. The HDR-VDP-2 quality indexes show similar improvements further confirming the superior performance of the backward-compatible solutions.
Influence of Active Queue Management Parameters on Aggregate Traffic Performance (2000)

Active queue management (AQM) is a family of packet dropping mechanisms for FIFO queues that have been proposed to support end-to-end congestion control mechanisms in the Internet. In this paper, we examine the four possible combinations of queue size averaging vs instantaneous queue size and a sharp dropping function vs a smooth dropping function. The combinations include both the well known "Drop from Tail" (TD) and "RED" mechanisms as well as the more recently proposed "Gentle RED" and a previously unrecognized mechanism we call "Gentle RED with instantaneous queue size", or GRED-I. The results show the end-to-end performance of the four AQM mechanisms. Thus, we do not study individual TCP flow performance but instead the flow aggregation behavior through backbone nodes, and we chose experimental parameters and observed metrics accordingly. We show that if TD and RED have similar behaviors in terms of aggregate TCP throughput, RED discards more non responsive traffic than TD. On the other hand, we show that RED creates more consecutive drops than TD. We identify queue size averaging and the slope of the dropping function as the two major parameters influencing consecutive drops.
Cross-ISA machine instrumentation using fast and scalable dynamic binary translation (2019)

The rise in instruction set architecture (ISA) diversity and the growing adoption of virtual machines are driving a need for fast, scalable, full-system, cross-ISA emulation and instrumentation tools. Unfortunately, achieving high performance for these cross-ISA tools is challenging due to dynamic binary translation (DBT) overhead and the complexity of instrumenting full-system emulators.
Inhibitory Effects of Antioxidants on Neonatal Rat Cardiac Myocyte Hypertrophy Induced by Tumor Necrosis Factor-α and Angiotensin II (1998)

These results indicate that TNF-alpha and Ang II cause hypertrophy in part via the generation of ROIs in cardiac myocytes.
I/O Design Flexibility with the FPGA Mezzanine Card (FMC) (2009)

The FPGA’s inherent flexibility has proven indispensable for the creation of external I/O interfaces. However, unless I/O is implemented on a daughter card (mezzanine module), replacing the physical I/O components and connectors requires changing the FPGA board design. To avoid these costs, designers have historically relied on the PCI™ Mezzanine Card (PMC) and Switched Mezzanine Card (XMC) standards. The problem is that these were developed years ago for general purpose solutions such as single-board computers— not FPGAs.