gebhart/patrepeval huggingface dataset:
Behavior of vehicle drivers while approaching an intersection after the traffic light signal changes from green to yellow (2018)

The article presents the results of research on the behavior of vehicle drivers while approaching the intersection, after the traffic light signal changes from green to yellow. In the above mentioned situation, the driver is required to stop the vehicle. Questionnaire surveys were conducted on a group of two hundred road traffic participants. The scope of the survey was the knowledge on how to react accordingly in the risk triggering situations. The objective of the survey was to get to know the participants' state of knowledge in the specified road traffic situation. The results were compared with the calculations and analyzes of possible behavior patterns arising from the legal regulations in force. Three rational procedure scenarios were selected. Each scenario is describing a possible reaction before the intersection after the transmission of a green signal has ended. The surprise reaction of the driver caused by the change of the signal and insufficient time for correct reaction, which is needed in order to evaluate the situation appropriately, results very often in the road traffic collisions or road traffic accidents. Therefore, it is crucial for the vehicle's driver to have the ability to react accordingly based on the acquired knowledge.
Automatic segmentation of myocardium at risk from contrast enhanced SSFP CMR: validation against expert readers and SPECT (2016)

NCT01379261. NCT01374321.
Mapping-free variant calling using haplotype reconstruction from k-mer frequencies (2017)

1 Abstract Motivation The standard protocol for detecting variation in DNA is to map millions of short sequence reads to a known reference and find loci that differ. While this approach works well, it cannot be applied where the sample contains dense variants or is too distant from known references. De novo assembly or hybrid methods can recover genomic variation, but the cost of computation is often much higher. We developed a novel k-mer algorithm and software implementation, Kestrel, capable of characterizing densely-packed SNPs and large indels without mapping, assembly, or de Bruijn graphs. Results When applied to mosaic penicillin binding protein (PBP) genes in Streptococcus pneumoniae, we found near perfect concordance with assembled contigs at a fraction of the CPU time. Multilocus sequence typing (MLST) with this approach was able to bypass de novo assemblies. Kestrel has a very low false-positive rate when calling variants over the whole genome, but limitations of a purely k-mer based approach affect sensitivity. Availability Source code and documentation for a Java implementation of Kestrel can be found at https://github.com/paudano/kestrel . All test code for this publication is located at https://github.com/paudano/kescases . Contact paudano@gatech.edu , fredrik.vannberg@biology.gatech.edu
Montmorillonite clay/poly(methyl methacrylate) hybrid resin and its barrier property to the plasticizer within poly(vinyl chloride) composite (1999)

A poly(methyl methacrylate) (PMMA)-clay hybrid resin was prepared via bulk polymerization methyl methacrylate monomer in the presence of montmorillonite intercalated with an ammonium salt of dctadecylamine. The products were characterized by infrared spectroscopy, X-ray diffraction, pyrolysis gas chromatography, and transmission electron microscopy. Results confirm that the resin is intercalated with PMMA molecules. The layer spacing of montmorillonite are enlarged, whereas the silicate layers are homogeneously dispersed individually. When the PMMA-clay hybrid was blended with plasticized poly(vinyl chloride), the resulting composite exhibited excellent barrier property in preventing the plastizer's migration from the inner matrix to the surface of the product. This is presumably caused by barrier property of the silicate layers dispersed in the composite. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 73: 425–430, 1999
An Explicit Finite-Element Model to Investigate the Effects of Elastomeric Bushing on Bearing Dynamics (2016)

This work presents a numerical simulation which studies the effect of elastomeric bushing on the dynamics of a deep-groove ball bearing. To achieve the objective, a three-dimensional (3D) explicit finite element method (EFEM) was developed to model a cylindrical elastomeric bushing, which was then coupled with an existing dynamic bearing model (DBM). Constitutive relationship for the elastomer is based on the Arruda–Boyce model combined with a generalized Maxwell-element model to capture both hyperelastic and viscoelastic behaviors of the material. Comparisons between the bushing model developed for this investigation and the existing experimental elastomeric bushing study showed that the results are in good agreement. Parametric studies were conducted to show the effects of various elastomeric material properties on bushing behavior. It was also shown that a desired bushing support performance can be achieved by varying bushing geometry. Simulations using the combined EFEM bushing and DBM model demonstrated that the elastomeric bushing provides better compliance to bearing misalignment as compared to a commonly used rigid support model. As a result, less ball slip and spin are generated. Modeling with a bearing surface dent showed that vibrations due to surface abnormalities can be significantly reduced using elastomeric bushing support. It has also been shown that choosing a proper bushing is an efficient way to tuning bushing vibration frequencies.
Adaptive quantum design of atomic clusters (2004)

Adaptive quantum design identifies the best broken-symmetry configurations of atoms and molecules that enable a desired target function response. In this work, numerical optimization is used to design atomic clusters with specified quasiparticle densities of states. The dominant self-assembled building blocks of these engineered quantum systems are found to depend on the symmetry of the target function. For example, particle-hole symmetric spectra can be constructed from a dilute configuration of atomic dimers, whereas more complex structures such as trimers and quadrumers are required for asymmetric target functions. The convergence of the optimization algorithms depends on the shape of the target function, the density of atoms, and constraints due to substrates and boundary conditions. Hybrids of steepest-descent methods, simulated annealing, and genetic algorithms are found to be most efficient.
Exploiting Low-cost depth Cameras for Body Measurement in the Livestock Sector (2018)

Animal dimensions play a key role in providing data in support of management decisions regarding livestock production. In the last fifty years, manual measurements have been the most common way to get an indication of animal growth. An alternative approach, which overcomes the limitations of manual direct measurements, is to use techniques based on optical detection instruments.
Introduction: Strategies and Realities (1989)

The term ‘antisense’ has entered the popular vocabulary as a term denoting a novel approach to chemotherapy. The field that is encompassed by this term has blossomed to such an extent that it has now reached the stage of popularization (Chase, 1988; Kolata, 1988). But the basis for this approach, and the many assumptions and pitfalls involved in it, cannot be dealt with in a limited popular treatment.
Development of a new acyl anion equivalent for the preparation of masked activated esters, and their use to prepare a dipeptide (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment of a new acyl anion equivalent for the preparation of masked activated esters, and their use to prepare a dipeptideHisao Nemoto, Yasufumi Kubota, and Yoshinori YamamotoCite this: J. Org. Chem. 1990, 55, 15, 4515–4516Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://doi.org/10.1021/jo00302a008Request reuse permissionsArticle Views2090Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (299 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
MobiCon: Mobile context monitoring platform: Incorporating context-awareness to smartphone-centric personal sensor networks (2012)

In this demonstration, we will show MobiCon, a context monitoring platform; it runs over smartphones and sensor OSs, and facilitates development and deployment of everyday context-aware applications. For many years, lots of research efforts have been made in building low-cost, yet effective sensor networks for various application domains such as structural health monitoring of bridges, disaster recovery, automated ventilation of buildings. Integration of sensors into smartphones and the advent of wearable devices open a new opportunity for mobile applications to leverage in-situ user contexts such as his/her location, activity, social relationship, health status. In recent studies of mobile and pervasive computing, a number of useful mobile context-aware applications have been proposed, but their actual deployment is slow due to complexity of context processing and heavy resource and battery usage. To address such challenges, we have been building MobiCon for many years, upon which diverse context-aware applications are developed and deployed without concerns about complexity of context processing and resource optimization.
Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein (1987)

Tetranectin binds to plasminogen and to isolated kringle 4 [Clemmensen, I., Petersen, L. C., & Kluft, C. (1986) Eur. J. Biochem. 156, 327-333], apparently to its lysine-binding site. Each of the four identical chains consists of 181 amino acid residues. The three intrachain disulfide bonds connect Cys residues 50-60, 77-176, and 152-168. The tetranectin sequence is homologous (17-24% identical positions) with those parts of the asialoglycoprotein receptor family that are considered to be extracellular. Tetranectin has no structures corresponding to those parts of the receptors considered to be intracellular and membrane anchoring. The sequence of tetranectin is also homologous (22-23% identical positions) with the C-terminal globular domain of the core protein of the cartilage proteoglycan. All six Cys residues in tetranectin are located at positions that are also Cys residues in this proteoglycan. Therefore, a plausible disulfide bond pattern can now be proposed for both the asialoglycoprotein receptors and the C-terminal domain of the proteoglycan core protein. No covalently bound carbohydrate has been found.
Degradation of DNA RNA Hybrids by Ribonuclease H and DNA Polymerases of Cellular and Viral Origin (1972)

Ribonuclease H from human KB cells, chick embryos, calf thymus, avian myeloblastosis virus, and Rous associated virus specifically degrades the RNA of DNA.RNA hybrids, producing mono- and oligoribonucleotides terminated in 5'-phosphates. The cellular RNase H is an endonuclease, whereas the viral enzyme appears to be an exonuclease. Viral DNA polymerase and RNase H copurify through all separation steps. Therefore, RNase H activity is an intrinsic part of the viral DNA polymerase. DNA.RNA hybrids are also degraded by nucleases associated with cellular DNA polymerases and by exonuclease III. However, these nucleases differ from RNase H in their ability to degrade both strands of DNA.RNA hybrids.
Water-soluble, highly emissive, color-tunable, and stable Cu-doped ZnSeS/ZnS core/shell nanocrystals (2014)

Water-soluble, highly emissive, color-tunable, and stable Cu:ZnSeS/ZnS core/shell doped nanocrystals (d-dots) with pure dopant emission have been synthesized through a simple aqueous synthetic route. The influence of various experimental variables, including introduction of chloride ions, amount of mercaptopropanoic acid (MPA), pH value and Cu-doping concentration, on the optical properties of Cu dopant emission have been systematically investigated. Through epitaxial growth of a ZnS shell on Cu:ZnSeS cores, the fabricated Cu:ZnSeS/ZnS d-dots exhibit a high PL QY of up to 40%, which is the highest ever reported for any type of water-soluble Cu-doped selenide-based II–VI semiconductor nanocrystals (NCs). Moreover, the serious photostability problem of Cu-based d-dots in the presence of air and light is solved and the quenching of the excitonic emission is suppressed as well. The stable testing of these highly luminescent d-dots shows that the Cu:ZnSeS/ZnS d-dots have better photostability and preserve more than ~90% of the initial intensity in the presence of air and light 30 days later. This new class of green emissive material shows their potential applications in biolabeling, bioimaging, and light emitting devices.
Pedestrian navigation based on inertial sensors, indoor map, and WLAN signals (2012)

As satellite signals, e.g. GPS, are severely degraded indoors or not available at all, other methods are needed for indoor positioning. In this paper, we propose methods for combining information from inertial sensors, indoor map, and WLAN signals for pedestrian indoor navigation. We present results of field tests where complementary extended Kalman filter was used to fuse together WLAN signal strengths and signals of an inertial sensor unit including one gyro and three-axis accelerometer. A particle filter was used to combine the inertial data with map information. The results show that both the map information and WLAN signals can be used to improve the pedestrian dead reckoning estimate based on inertial sensors.
Towards transactive energy systems: An analysis on current trends (2019)

This paper presents a comprehensive analysis on the latest advances in transactive energy systems. The main contribution of this work is centered on the definition of transactive energy concepts and how such systems can be implemented in the smart grid paradigm. The analyzed works have been categorized into three lines of research: (i) transactive network management; (ii) transactive control; and (iii) peer-to-peer markets. It has been found that most of the current approaches for transactive energy are available as a model, lacking the real implementation to have a complete validation. For that purpose, both scientific and practical aspects of transactive energy should be studied in parallel, implementing adequate simulation platforms and tools to scrutiny the results.
Involvement of cathepsin B in the processing and secretion of interleukin‐1β in chromogranin A‐stimulated microglia (2009)

Cathepsin B (CB) is a cysteine lysosomal protease implicated in a number of inflammatory diseases. Although it is now evident that caspase-1, an essential enzyme for maturation of interleukin-1beta (IL-1beta), can be activated through the inflammasome, there is still evidence suggesting the existence of lysosomal-proinflammatory caspase pathways. In the present study, a marked induction of pro-IL-1beta, its processing to the mature form and secretion were observed in the primary cultured microglia prepared from wild-type mice after stimulation with chromogranin A (CGA). Although pro-IL-1beta also markedly increased in microglia prepared from CB-deficient mice, CB-deficiency abrogated the pro-IL-1beta processing. CA-074Me, a specific inhibitor for CB, inhibited the pro-IL-1beta maturation and its release from microglia. Furthermore, the caspase-1 activation was also inhibited by CA-074Me and E-64d, a broad cysteine protease inhibitor. After treatment with CGA, CB was markedly induced at both protein and mRNA levels. The induced pro-CB was rapidly processed to its mature form. The immunoreactivity for CB co-localized with both that for caspase-1 and the cleaved IL-1beta, in the acidic enlarged lysosomes. Inconsistent with these in vitro observations, the immunoreactivity for the cleaved IL-1beta was markedly observed in microglia of the hippocampus from aged wild-type but not CB-deficient mice. These observations strongly suggest that CB plays a key role in the pro-IL-1beta maturation through the caspase-1 activation in enlarged lysosomes of CGA-treated microglia. Therefore, either pharmacological or genetic inhibition of CB may provide therapeutic intervention in inflammation-associated neurological diseases.
Resolving the Hemodynamic Inverse Problem (2006)

The "hemodynamic inverse problem" is the determination of arterial system properties from pressures and flows measured at the entrance of an arterial system. Conventionally, investigators fit reduced arterial system models to data, and the resulting model parameters represent putative arterial properties. However, no unique solution to the inverse problem exists-an infinite number of arterial system topologies result in the same input impedance (Zin) and, therefore, the same pressure and flow. Nevertheless, there are exceptions to this theoretical limitation; total peripheral resistance (Rtot), total arterial compliance (Ctot), and characteristic impedance (ZO) can be uniquely determined from input pressure and flow. Zin is determined completely by Ctot and Rtot at low frequencies, Zo at high frequencies, and arterial topology and reflection effects at intermediate frequencies. We present a novel method to determine the relative contribution of Zo, Ctot, Rtot and arterial topology/reflection to Zin without assuming a particular reduced model. This method is tested with a large-scale distributed model of the arterial system, and is applied to illustrative cases of measured pressure and flow. This work, thus, lays the theoretical foundation for determining the arterial properties responsible for increased pulse pressure with age and various arterial system pathologies.
Inhibitory Effect of Cryptoporic Acid E, a Product from Fungus <i>Cryptoporus volvatus</i>, on Colon Carcinogenesis Induced with N‐Methyl‐N‐Nitrosourea in Rats and with 1,2‐Dimethylhydrazine in Mice (1992)

The antitumorigenic effect of cryptoporic acid E (CPA-E), a dimeric drimane sesquiterpenoid isolated from the fungus Cryptoporus volvatus, on colon carcinogenesis was investigated. Female F344 rats given an intrarectal instillation of 2 mg of N-methyl-N-nitrosourea 3 times weekly in weeks 1 and 2 were fed diet containing 0.2% CPA-E from week 3. Female ICR mice given 15 weekly intraperitoneal injections of 10 mg of 1,2-dimethylhydrazine/kg body weight during weeks 1 to 15 were fed diet containing 0.06% CPA-E from week 1. The experiment was terminated at week 35 for rats and at week 25 for mice. The incidence and the number of tumors per animal were reduced in CPA-E-fed animals compared to the controls: 31% vs. 75% (P less than 0.05) and 0.4 +/- 0.2 (SEM) vs. 0.9 +/- 0.2 (0.1 greater than P greater than 0.05) in rats, and 31% vs. 63% (0.1 greater than P greater than 0.05) and 0.4 +/- 0.2 vs. 2.4 +/- 0.8 (P less than 0.05) in mice (16 animals in each group). Intrarectal deoxycholic acid-induced colonic mucosal ornithine decarboxylase activity was significantly lowered in CPA-E-fed animals compared to controls. This shows an antipromoting activity of CPA-E against colon carcinogenesis. Thus, it was concluded that CPA-E inhibits colon cancer development in both rats and mice treated with 2 different colon carcinogens.
DCM-Operated Series-Resonant Inverter for the Supply of DBD Excimer Lamps (2013)

This paper presents the study of a series-resonant inverter for the supply of a dielectric barrier discharge excimer lamp. Causal analysis, based on the fundamental properties of the load, is used to detail the reasoning which has led to this topology. In order to effectively control the lamp power, the operating mode of this converter combines discontinuous current mode and soft commutation (zero-current switching), obtaining low electromagnetic emissions and reduced switching losses as well. The model of the lamp is briefly presented, and it allows a simple state plane analysis to calculate all the electric variables involved in the converter and, consequently, to select the components of the supply. The mathematical relationships obtained from this process, for injected power control by means of the available degrees of freedom, are validated with simulations and experimental results.
Suicide-Related Events in Patients Treated with Antiepileptic Drugs (2010)

The current use of antiepileptic drugs was not associated with an increased risk of suicide-related events among patients with epilepsy, but it was associated with an increased risk of such events among patients with depression and among those who did not have epilepsy, depression, or bipolar disorder.
Tsg101 chaperone function revealed by HIV-1 assembly inhibitors (2017)

HIV-1 replication requires Tsg101, a component of cellular endosomal sorting complex required for transport (ESCRT) machinery. Tsg101 possesses an ubiquitin (Ub) E2 variant (UEV) domain with a pocket that can bind PT/SAP motifs and another pocket that can bind Ub. The PTAP motif in the viral structural precursor polyprotein, Gag, allows the recruitment of Tsg101 and other ESCRTs to virus assembly sites where they mediate budding. It is not known how or even whether the UEV Ub binding function contributes to virus production. Here, we report that disruption of UEV Ub binding by commonly used drugs arrests assembly at an early step distinct from the late stage involving PTAP binding disruption. NMR reveals that the drugs form a covalent adduct near the Ub-binding pocket leading to the disruption of Ub, but not PTAP binding. We conclude that the Ub-binding pocket has a chaperone function involved in bud initiation.
Federated Patient Hashing (2020)

Privacy concerns on sharing sensitive data across institutions are particularly paramount for the medical domain, which hinders the research and development of many applications, such as cohort construction for cross-institution observational studies and disease surveillance. Not only that, the large volume and heterogeneity of the patient data pose great challenges for retrieval and analysis. To address these challenges, in this paper, we propose a Federated Patient Hashing (FPH) framework, which collaboratively trains a retrieval model stored in a shared memory while keeping all the patient-level information in local institutions. Specifically, the objective function is constructed by minimization of a similarity preserving loss and a heterogeneity digging loss, which preserves both inter-data and intra-data relationships. Then, by leveraging the concept of Bregman divergence, we implement optimization in a federated manner in both centralized and decentralized learning settings, without accessing the raw training data across institutions. In addition to this, we also analyze the convergence rate of the FPH framework. Extensive experiments on real-world clinical data set from critical care are provided to demonstrate the effectiveness of the proposed method on similar patient matching across institutions.