gebhart/patrepeval huggingface dataset:
Tolerance and withdrawal to anticonvulsant action of clonazepam:Role of nitric oxide (2000)

The use of clonazepam in the long-term treatment of epilepsy is greatly inhibited by its capacity to induce tolerance and dependence. A means of preventing or minimizing the tolerance and dependence inducing properties is required. Here the role of nitric oxide in preventing the development of tolerance and withdrawal hyperexcitability was studied. In Wistar rats, clonazepam at a dose of 0.25 mg/kg i.p. twice daily produced tolerance to its anticonvulsant action in 28 days. After sudden cessation of therapy it produced hyperexcitability. Tolerance was shown by a decrease in seizure threshold to near control value while withdrawal hyperexcitability was evidenced by a significant decrease in seizure threshold below the control value. L-Arginine (a donor of nitric oxide) and N omega-nitro-L-arginine (an inhibitor of nitric oxide synthase) were given in doses of 150 mg/kg and 8 mg/kg, respectively on day 1, 3, 7, 14, 21 and 28 with clonazepam. Withdrawal hyperexcitability was seen on day 1, 2 and 4 after cessation of drug therapy. Electroshock was used as a model of epilepsy and seizure thresholds were determined by an up and down method of Kimball et al. L-Arginine was found to inhibit the development tolerance as well as withdrawal hyperexcitability when administered with clonazepam while N omega-L-arginine did not prevent either the development of tolerance or withdrawal hyperexcitability in the electroshock model. In the PTZ model, however, L-arginine had no effect on the anticonvulsant action and withdrawal hyperexcitability while inhibition of nitric oxide synthesis prevented withdrawal hyperexcitability in PTZ-induced seizures.
Lithography with the scanning tunneling microscope (1986)

In a recent paper [McCord and Pease, J. Vac. Sci. Technol. B 3, 198 (1985)] we described how it should be possible to generate, for lithography and other materials processing, an electron beam with an extraordinary combination of high current (&gt;1 mA), low voltage (&lt;100 V) and small diameter (&lt;0.1 μm) using a modified scanning tunneling microscope (STM) operating in the field emission mode. To test this prediction we have built a modified STM onto the stage of a scanning electron microscope (SEM) so that we can monitor system geometry. The tip, an etched tungsten wire, can be manually moved in the z direction (normal to the target) for coarse motion and three PZT piezoelectric transducers allow 10 μm travel in the x, y, and z directions. A feedback system stabilizes the field emission current (and hence the tip-to-target spacing). We have obtained beams with currents from 1 nA to several microamps at voltages from 1 to 1000 V. We have used the beam to produce lines of contamination on a gold film; the contamination was then used as a mask against sputter etching to produce gold lines. In addition we have exposed a Langmuir–Blodgett resist film. In both cases we have produced sub-tenth-micron lines.
Optical Biopsy of Human Bladder Neoplasia With In Vivo Confocal Laser Endomicroscopy (2009)

We report the first study to our knowledge of in vivo confocal laser endomicroscopy in the urinary tract. Marked differences among normal urothelium, low grade tumors and high grade tumors were visualized. Pending further clinical investigation and technological improvement, confocal laser endomicroscopy may become a useful adjunct to conventional cystoscopy.
Jackknife Kernel Density Estimation Using Uniform Kernel Function in the Presence of k's Unidentified Outliers (1995)

The purpose of this paper is to propose the kernel density estimator and the jackknife kernel density estimator in the presence of k's unidentified outliers, and to compare the small sample performances of the proposed estimators in a sense of mean integrated square error(MISE).
GCR1 Can Act Independently of Heterotrimeric G-Protein in Response to Brassinosteroids and Gibberellins in Arabidopsis Seed Germination  (2004)

Signal recognition by seven-transmembrane (7TM) cell-surface receptors is typically coupled by heterotrimeric G-proteins to downstream effectors in metazoan, fungal, and amoeboid cells. Some responses perceived by 7TM receptors in amoeboid cells and possibly in human cells can initiate downstream action independently of heterotrimeric G-proteins. Plants use heterotrimeric G-protein signaling in the regulation of growth and development, particularly in hormonal control of seed germination, but it is not yet clear which of these responses utilize a 7TM receptor. Arabidopsis GCR1 has a predicted 7TM-spanning domain and other features characteristic of 7TM receptors. Loss-of-function gcr1 mutants indicate that GCR1 plays a positive role in gibberellin- (GA) and brassinosteroid- (BR) regulated seed germination. The null mutants of GCR1 are less sensitive to GA and BR in seed germination. This phenotype is similar to that previously observed for transcript null mutants in the Galpha-subunit, gpa1. However, the reduced sensitivities toward GA and BR in the single gcr1, gpa1, and agb1 (heterotrimeric G-protein beta-subunit) mutants are additive or synergistic in the double and triple mutants. Thus, GCR1, unlike a typical 7TM receptor, apparently acts independently of the heterotrimeric G-protein in at least some aspects of seed germination, suggesting that this alternative mode of 7TM receptor action also functions in the plant kingdom.
Accurate rendering by subpixel addressing (1990)

A simple method is presented for eliminating most pixel-positioning errors when rendering lines and polygons with J.E. Bresenham's algorithm (see IBM Syst. J., vol.4, no.1, p.25-30 (1965)). The method affects only the calculation of the initial values for Bresenham's vector-generating algorithm. It does not alter the actual vector-generating algorithm, requiring only inter arithmetic to find the next pixel in a vector. The method eliminates all dropouts and virtually all overlaps between adjacent polygons whose edges lie on the same line. This eliminates the need to grow polygons to avoid dropout and opens the possibility of drawing surfaces composed of adjacent polygons with read modify/write pixel operations such as add or alpha buffering. It is shown that most rendering artifacts of today's display controllers ultimately result from pixel-positioning errors, not insufficient z-buffer resolution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Harnessing the parathyroids to create stronger bones (2004)

Attempting to correct the circadian rhythm in osteoporotic patients by calcilytic drugs or perhaps physiological equivalents may have a role in the future in treating osteoporosis. In the meantime, the administration of recombinant parathyroid hormone is an effective agent in the management of osteoporosis.
Update on the statistical analysis of bioequivalence studies. (1990)

Statistical methods to assess bioequivalence of a test and a reference formulation are reviewed with emphasis on the distribution of bioequivalence characteristics and the consumer risk of erroneously accepting bioequivalence. Among the procedures not exceeding a nominal consumer risk of 5%, the one with an acceptably small producer risk of erroneously rejecting bioequivalence is selected. With the exception of tmax, the following strategy is recommended: a decision in favour of bioequivalence is made if the shortest 90%-confidence interval for the ratio of the expected medians is in the bioequivalence range for the chosen characteristics of rate and extent of absorption. If the assumption of a logarithmic normal distribution is not valid, the analogous nonparametric (distribution-free) 90%-confidence interval, which is also based on the two-sample approach for the sequences reference/test and test/reference, is the procedure of choice. The issue of a modification of the bioequivalence range of 80-120% to other values for bioequivalence characteristics other than AUC (e.g. Cmax) is also addressed. Finally, a decision rule for tmax is presented.
Assessing the Generalizability of Code2vec Token Embeddings (2019)

Many Natural Language Processing (NLP) tasks, such as sentiment analysis or syntactic parsing, have benefited from the development of word embedding models. In particular, regardless of the training algorithms, the learned embeddings have often been shown to be generalizable to different NLP tasks. In contrast, despite recent momentum on word embeddings for source code, the literature lacks evidence of their generalizability beyond the example task they have been trained for. In this experience paper, we identify 3 potential downstream tasks, namely code comments generation, code authorship identification, and code clones detection, that source code token embedding models can be applied to. We empirically assess a recently proposed code token embedding model, namely code2vec's token embeddings. Code2vec was trained on the task of predicting method names, and while there is potential for using the vectors it learns on other tasks, it has not been explored in literature. Therefore, we fill this gap by focusing on its generalizability for the tasks we have identified. Eventually, we show that source code token embeddings cannot be readily leveraged for the downstream tasks. Our experiments even show that our attempts to use them do not result in any improvements over less sophisticated methods. We call for more research into effective and general use of code embeddings.
Object-Oriented Deep Learning (2017)

We investigate an unconventional direction of research that aims at converting neural networks, a class of distributed, connectionist, sub-symbolic models into a symbolic level with the ultimate goal of achieving AI interpretability and safety. To that end, we propose Object-Oriented Deep Learning, a novel computational paradigm of deep learning that adopts interpretable “objects/symbols” as a basic representational atom instead of N-dimensional tensors (as in traditional “feature-oriented” deep learning). For visual processing, each “object/symbol” can explicitly package common properties of visual objects like its position, pose, scale, probability of being an object, pointers to parts, etc., providing a full spectrum of interpretable visual knowledge throughout all layers. It achieves a form of “symbolic disentanglement”, offering one solution to the important problem of disentangled representations and invariance. Basic computations of the network include predicting high-level objects and their properties from low-level objects and binding/aggregating relevant objects together. These computations operate at a more fundamental level than convolutions, capturing convolution as a special case while being significantly more general than it. All operations are executed in an input-driven fashion, thus sparsity and dynamic computation per sample are naturally supported, complementing recent popular ideas of dynamic networks and may enable new types of hardware accelerations. We experimentally show on CIFAR-10 that it can perform flexible visual processing, rivaling the performance of ConvNet, but without using any convolution. Furthermore, it can generalize to novel rotations of images that it was not trained for.
Evolution of Quantum Algorithms using Genetic Programming (2004)

Automatic quantum circuit design is motivated by the difficulties in manual design, because quantum algorithms are highly non-intuitive and practical quantum computer hardware is not yet available. Thus, quantum computers have to be simulated on classical hardware which naturally entails an exponential growth of computational costs and allows only to simulate small quantum systems, i. e., with only few qubits. Huge search spaces render evolutionary approaches nearly unable to achieve breakthrough solutions in the development of new quantum algorithms. Consequently, at present we must be content to evolve essentially already existing (black-box) quantum algorithms. This thesis presents empirical results on the evolution of quantum circuits using genetic programming. For that purpose, a linear and a linear-tree GP system (allowing intermediate measurements) with integrated quantum computer simulator were implemented. Their practicality in evolving quantum circuits is shown in different experiments for 1-SAT (solutions act like Hogg's algorithm) and the Deutsch-Jozsa problem. These experiments confirm that the evolution of quantum circuits is practically feasible only for sufficiently small problem instances. In this context, scalability and the detection of scalability becomes very important. It is shown that scalable quantum circuits are evolvable to a certain degree: a general quantum circuit can be inferred manually from the evolved solutions for small instances of the given problem. Besides, further experiments indicate that 're-evolution' is effective for the evolution of scalable quantum circuits. With this method the start population of a problem instance is inoculated with evolved solutions for a smaller problem instance. Furthermore, investigations of fitness landscapes and selection strategies are made, with the aim of improving the efficiency of evolutionary search. A notable result is that using the crossover operator damages rather than benefits evolution of quantum circuits.
Stabilization of optical phase/frequency of a laser system: application to a commercial dye laser with an external stabilizer (1993)

We present a comprehensive and quasi-tutorial review of the theory for analyzing the optical power spectrum of an optical field that has noise modulations of both the amplitude and the phase. We also present experimental results of the frequency stabilization of a commercial dye laser to a high-finesse Fabry–Perot cavity (0.49-Hz resulting full linewidth) and of the optical phase locking of the dye laser to a second reference laser (putting 97% of the optical power into the carrier) using an external stabilizer scheme. This external optical phase/frequency stabilization technique can be applied to virtually any cw laser system.
Grain Boundary Sliding in Aluminum Nano‐Bi‐Crystals Deformed at Room Temperature (2013)

Room-temperature uniaxial compressions of 900-nm-diameter aluminum bi-crystals, each containing a high-angle grain boundary with a plane normal inclined at 24° to the loading direction, revealed frictional sliding along the boundary plane to be the dominant deformation mechanism. The top crystallite sheared off as a single unit in the course of compression instead of crystallographic slip and extensive dislocation activity, as would be expected. Compressive stress strain data of deforming nano bicrystals was continuous, in contrast to single crystalline nano structures that show a stochastic stress strain signature, and displayed a peak in stress at the elastic limit of ~ 176 MPa followed by gradual softening and a plateau centered around ~ 125 MPa. An energetics-based physical model, which may explain observed room-temperature grain boundary sliding, in presented, and observations are discussed within the framework of crystalline nano-plasticity and defect microstructure evolution.
The Effect of Multi-Directional Stimuli on the Stiction-Induced Failure Behavior of MEMS (2016)

The occurrence of adhesion-induced failures at microelectromechanical systems (MEMSs), also referred to as stiction, can be triggered by a variety of environmental, geometrical, and operational parameters, such as compressive contact forces acting in normal direction between two micromechanical surfaces. The knowledge of these parameters is essential for conducting and evaluating stiction-related reliability tests at MEMS. This paper investigates the operational parameter of tangential contact forces, which can occur in case of multi-directional overloads like shocks or vibrations during manufacturing, handling, or final application of MEMS inertial sensors. Tangential contact forces act in parallel to a contact area and are shown to affect the stiction-induced failure behavior of MEMS. For this purpose, three different types of test devices have been exposed to electrical as well as mechanical stimuli with and without cross-axes excitation contents, stimulating the occurrence of tangential forces during contact. The transient system responses of the test devices were calculated based on reduced-order impact models, allowing a detailed comparison of load conditions between different stimuli and test devices. The obtained results show that tangential contact forces lead to higher stiction rates, which indicates increased adhesion forces compared with excitations without tangential forces.
Treatment of type 1 diabetes mellitus in non-obese diabetic mice by transplantation of allogeneic bone marrow and pancreatic tissue. (1987)

Non-obese diabetic (NOD) mice provide a model for type 1 diabetes mellitus. We previously showed that allogeneic bone marrow transplantation (ABMT) can prevent and treat insulitis and overt diabetes in NOD mice. However, ABMT alone could not be used to treat overt diabetes in NOD mice whose islets had been completely destroyed. To provide insulin-producing cells, pancreatic tissue from newborn mice was grafted under the renal capsules in combination with ABMT. The aims of concomitant ABMT are as follows. (i) It induces immunological tolerance to the donor-type major histocompatibility complex determinants and permits the host to accept subsequent pancreatic allografts from the bone marrow donor. (ii) ABMT replaces abnormal stem cells with normal stem cells. After transplantation of bone marrow plus newborn pancreas, NOD mice showed reduction of the glycosuria and a normal response in the glucose-tolerance test. Immunohistological study revealed the presence of clustered insulin-containing beta cells in the grafted pancreatic transplants. ABMT may become a viable treatment of established type 1 diabetes mellitus in humans.
CMOS voltage references using lateral bipolar transistors (1985)

Two bandgap references are presented which make use of CMOS compatible lateral bipolar transistors. The circuits are designed to be insensitive to the low beta and alpha current gains of these devices. Their accuracy is not degraded by any amplifier offset. The first reference has an intrinsic low output impedance. Experimental results yield an output voltage which is constant within 2 mV, over the commercial temperature range (0 to 70/spl deg/C), when all the circuits of the same batch are trimmed at a single temperature. The load regulation is 3.5 /spl mu/V//spl mu/A, and the power supply rejection ratio (PSRR) at 100 Hz is 60 dB. Measurements on a second reference yield a PSRR of minimum 77 dB at 100 Hz. Temperature behaviour is identical to the first circuit presented. This circuit requires a supply voltage of only 1.7 V.
Clinical outcome measures for progressive MS trials (2017)

Treatment options for progressive multiple sclerosis remain the main unmet need of the field. As the understanding of multiple sclerosis (MS) pathogenesis improves, new pathways and molecules will be tested for potential reparative, remyelinating, or neuroprotective effects. The clinical outcomes used will determine successful demonstration of beneficial treatment effects to regulatory agencies, clinicians, and persons with MS. This review focuses on clinical outcome measures including the Expanded Disability Status Scale, Multiple Sclerosis Functional Composite, and novel composite measures of disability. The paper also covers cognitive outcomes and screening tests for use in clinical trials. The growing importance of patient-reported outcomes and their suitability for clinical trials is also presented. The review aims to create consensus in regard to these topics and suggestions for future research.
Human Herpesvirus‐6 Induces MVB Formation, and Virus Egress Occurs by an Exosomal Release Pathway (2008)

The final envelopment of most herpesviruses occurs at Golgi or post-Golgi compartments, such as the trans Golgi network (TGN); however, the final envelopment site of human herpesvirus 6 (HHV-6) is uncertain. In this study, we found novel pathways for HHV-6 assembly and release from T cells that differed, in part, from those of alphaherpesviruses. Electron microscopy showed that late in infection, HHV-6-infected cells were larger than uninfected cells and contained many newly formed multivesicular body (MVB)-like compartments that included small vesicles. These MVBs surrounded the Golgi apparatus. Mature virions were found in the MVBs and MVB fusion with plasma membrane, and the release of mature virions together with small vesicles was observed at the cell surface. Immunoelectron microscopy demonstrated that the MVBs contained CD63, an MVB/late endosome marker, and HHV-6 envelope glycoproteins. The viral glycoproteins also localized to internal vesicles in the MVBs and to secreted vesicles (exosomes). Furthermore, we found virus budding at TGN-associated membranes, which expressed CD63, adaptor protein (AP-1) and TGN46, and CD63 incorporation into virions. Our findings suggest that mature HHV-6 virions are released together with internal vesicles through MVBs by the cellular exosomal pathway. This scenario has significant implications for understanding HHV-6's maturation pathway.
Synthesis, characterization, and properties of novel polyetherester polyols and developed polyurethanes (2006)

Abstract Three kinds of cyclic anhydrides, which stand for aliphatic anhydride, aromatic anhydride, and anhydride containing double bond: succinic anhydride, phthalic anhydride, and maleic anhydride have been copolymerized with propylene oxide and low molecular weight polyoxypropylenediol via ring‐opening copolymerization initiator by double metal cyanide complex catalyst to synthesis a series of polyetherester (PEE) polyols. The structure of the obtained copolymers was confirmed by several analysis methods. Three kinds of polyetherester polyurethane (PEEPU) were thus synthesized by polymerization of as‐synthesized PEE polyol with 4,4′‐diphenylmethane diisocyanate. The mechanical properties of the obtained PEEPU were tested. The results showed that the mechanical properties of three polyurethanes are different based on their structure and composition. The inducing of the rigid phenyl group in the soft segment can improve the mechanical strength remarkably. The influences of ester content in soft segment and the hard segment content on the mechanical properties of PEEPU were studied. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 417–424, 2007
Evolving concepts of tumor heterogeneity (2014)

Past and recent findings on tumor heterogeneity have led clinicians and researchers to broadly define cancer development as an evolving process. This evolutionary model of tumorigenesis has largely been shaped by seminal reports of fitness-promoting mutations conferring a malignant cellular phenotype. Despite the major clinical and intellectual advances that have resulted from studying heritable heterogeneity, it has long been overlooked that compositional tumor heterogeneity and tumor microenvironment (TME)-induced selection pressures drive tumor evolution, significantly contributing to tumor development and outcomes of clinical cancer treatment. In this review, we seek to summarize major milestones in tumor evolution, identify key aspects of tumor heterogeneity in a TME-dependent evolutionary context, and provide insights on the clinical challenges facing researchers and clinicians alike.
Ultrasonic preparation of tungsten disulfide single-layers and quantum dots (2015)

Natural raw mineral tungstenite (WS<sub>2</sub>) was exfoliated to single-layer sheets using high intensity ultrasound.