gebhart/patrepeval huggingface dataset:
Autoantibodies to double-stranded (ds)DNA immunoprecipitate 18S ribosomal RNA by virtue of their interaction with ribosomal protein S1 and suppress <i>in vitro</i> protein synthesis (1996)

We report that four systemic lupus erythematosus (SLE) patient sera containing anti-dsDNA antibodies, three affinity-purified anti-dsDNA IgG, and a human anti-dsDNA MoAb (33.H11) immunoprecipitate 18S ribosomal RNA from DNase-treated 32P-labelled MOLT4 cell extract. This 18S RNA precipitation was inhibited completely by preincubating 33.H11 with calf thymus dsDNA or the recombinant human ribosomal protein S1, which was reported to cross-react with anti-dsDNA antibodies (J Immunol 1996; 156:1668-75). Whole IgG from three SLE sera with anti-dsDNA antibodies, 33.H11, and three affinity-purified anti-dsDNA IgG inhibited in vitro translation of globin mRNA (percent inhibition was 36-50%). This translation inhibition by anti-dsDNA antibodies was enhanced (67-79%) when the reticulocyte lysate was treated with DNase. Suppression of protein synthesis could be a pathogenic mechanism of anti-dsDNA antibodies, since it has also been shown that anti-dsDNA penetrates living cells (J Immunol 1995; 154:4857-64) in culture.
Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins (1990)

Several 3'-substituted cephalosporin sulfones were synthesized from 3-(hydroxymethyl)cephalosporin, which was prepared by Ti(OiPr)4 hydrolysis of the corresponding acetate. A method was also developed to prepare a 3-vinylcephalosporin. Some of these compound were found to be potent time-dependent inhibitors of human leukocyte elastase (HLE). The HLE inhibitory activity was correlated with sigma 1 and it was concluded that the potency was determined by the electron-withdrawing ability as well as the size of the substituent. A mechanism for inhibition of HLE by cephalosporin sulfones is proposed.
Reentrant Fiber Raman Gyroscope (1986)

Reentrant fiber optic gyroscopes offer the advantages of an inherent linear scale factor and a frequency readout, as in ring laser gyroscopes, but without associated lock-in effect. In the re-entrant gyroscope scheme, counterpropagating signal pulses can recirculate many times around a closed fiber loop, which enhances the Sagnac effect proportionally to the number of recirculations. When optical gain is provided in the loop to compensate for the round-trip signal loss, a large number of recirculations can be obtained, permitting sensitive rotation measurement. The system output then consists of a pulse train with sinusoidally modulated envelope. The modulation frequency is given by F = Dü/ηλ, where D is the loop diameter, n the refractive index at the signal wavelength A, and Ω the rotation rate.
SCAPE:  A New Tool for the Selective CApture of PEptides in Protein Identification (2005)

A method for the selective capture and analysis of peptides containing neither histidine nor arginine is evaluated. It is based on the reversible modification of alpha- and epsilon-amino groups of peptides and the relatively easy separation of charged and noncharged peptides by cation exchange chromatography. The simplicity of the method and the results obtained in silico and with standard proteins, anticipate the utility of the SCAPE approach for proteome analyses.
6.4: Multi‐mode LCD with Wide View Angle and High Reflectance for Sunlight Readability (2011)

Abstract A multi‐mode liquid crystal display LCD is proposed which typically shows color images in the transmissive mode and the transflective mode, and black and white images in the reflective mode. The multi‐mode LCD has the advantages of wide view angle and high reflectance for sunlight readability with low power consumption. A 10.1″ multi‐mode 3Qi LCD with LED backlight unit is demonstrated with wide view angle and 27% reflectance ideal for both notebook and electric reader applications.
Characterization of dispersion in higher order mode fibers using electrical spectrum measurements (2003)

We present a technique for measuring the chromatic dispersion of the higher order modes in kilometer lengths of fiber. The LP/sub 02/ dispersion is measured for several different fibers, and accuracies better than 1% are achieved.
Towards Accurate Duplicate Bug Retrieval Using Deep Learning Techniques (2017)

Duplicate Bug Detection is the problem of identifying whether a newly reported bug is a duplicate of an existing bug in the system and retrieving the original or similar bugs from the past. This is required to avoid costly rediscovery and redundant work. In typical software projects, the number of duplicate bugs reported may run into the order of thousands, making it expensive in terms of cost and time for manual intervention. This makes the problem of duplicate or similar bug detection an important one in Software Engineering domain. However, an automated solution for the same is not quite accurate yet in practice, in spite of many reported approaches using various machine learning techniques. In this work, we propose a retrieval and classification model using Siamese Convolutional Neural Networks (CNN) and Long Short Term Memory (LSTM) for accurate detection and retrieval of duplicate and similar bugs. We report an accuracy close to 90% and recall rate close to 80%, which makes possible the practical use of such a system. We describe our model in detail along with related discussions from the Deep Learning domain. By presenting the detailed experimental results, we illustrate the effectiveness of the model in practical systems, including for repositories for which supervised training data is not available.
The structure of inverses in schema mappings (2010)

A schema mapping is a specification that describes how data structured under one schema (the source schema) is to be transformed into data structured under a different schema (the target schema). The notion of an inverse of a schema mapping is subtle, because a schema mapping may associate many target instances with each source instance, and many source instances with each target instance. In PODS 2006, Fagin defined a notion of the inverse of a schema mapping. This notion is tailored to the types of schema mappings that commonly arise in practice (those specified by “source-to-target tuple-generating dependencies”, or s-t tgds ). We resolve the key open problem of the complexity of deciding whether there is an inverse. We also explore a number of interesting questions, including: What is the structure of an inverse? When is the inverse unique? How many nonequivalent inverses can there be? When does an inverse have an inverse? How big must an inverse be? Surprisingly, these questions are all interrelated. We show that for schema mappings M specified by full s-t tgds (those with no existential quantifiers), if M has an inverse, then it has a polynomial-size inverse of a particularly nice form, and there is a polynomial-time algorithm for generating it. We introduce the notion of “essential conjunctions” (or “essential atoms” in the full case), and show that they play a crucial role in the study of inverses. We use them to give greatly simplified proofs of some known results about inverses. What emerges is a much deeper understanding about this fundamental and complex operator.
Classification of Roadway Infrastructure and Collaborative Automated Driving System (2023)

<div>The latest developments in vehicle-to-infrastructure (V2I) and vehicle-to-anything (V2X) technologies enable all the entities in the transportation system to communicate and collaborate to optimize transportation safety, mobility, and equity at the system level. On the other hand, the community of researchers and developers is becoming aware of the critical role of roadway infrastructure in realizing automated driving. In particular, intelligent infrastructure systems, which leverage modern sensors, artificial intelligence, and communication capabilities, can provide critical information and control support to connected and/or automated vehicles to fulfill functions that are infeasible for automated vehicles alone due to technical or cost considerations. However, there is limited research on formulating and standardizing the intelligence levels of road infrastructure to facilitate the development, as the SAE automated driving levels have done for automated vehicles. This article proposes a five-level intelligence definition for intelligent roadway infrastructure, namely, connected and automated highway (CAH). The CAH is a subsystem of the more extensive collaborative automated driving system (CADS), along with the connected automated vehicle (CAV) subsystem. Leveraging the intelligence definition of CAH, the intelligence definition for the CADS is also defined. Examples of how the CAH at different levels operates with the CAV in the CADS are also introduced to demonstrate the dynamic allocation of various automated driving tasks between different entities in the CADS.</div>
Cytotoxicity and antitumor activity of some tetrahedral bis(diphosphino)gold(I) chelates (1990)

We report the cytotoxicity toward B16 cells and antitumor activity in three transplantable tumor models of a series of ionic, tetrahedral, bischelated gold diphosphine complexes of the type [Au1(R2PYPR2')2]X, where Y = (CH2)2, (CH2)3, or cis-CH = CH. The anion (X = Cl, Br, I, CH3SO3, NO3, PF6) had little effect upon activity. The R = R' = phenyl complexes 1, 7, and 8 [Y = (CH2)2, (CH2)3, cis-CH = CH, X = Cl] were the most active against P388 leukemia, with an increase in lifespan ranging from 83 to 92% and were also active against M5076 sarcoma and B16 melanoma. Complexes with pyridyl or fluorophenyl substituents had reduced activities. For the latter, 19F and 31P NMR were used to verify the formation of bischelated gold(I) complexes in solution. The reduced activity of the complex with R = Et and R' = Ph and inactivity with R = R' = Et are discussed in terms of their increased reactivity as reducing agents. 31P NMR studies show that [AuI(Et2P(CH2)2PPh2)2]Cl readily reacts with serum, albumin, and Cu2+ ions to give oxidized ligand.
A technique for projection x-ray lithography using ,computer- holograms (1999)

X-ray projection lithography has recently been explored as a method for the manufacture of < 200 nm linewidth integrated circuits. ‘A method is described whereby projected lithographic images can be formed with x rays by means of a transmission hologram. Theform of the hologram is computed by an algorithm that eliminates the unwanted signals normally present as systematic errors in in-line holographic images. Example calculations are shown in which holograms are constructed to generate images of a given test pattern. The holographic images are shown to have excellent fidelity with respect to both resolution and contrast. Such an approach to projection x-ray lithography requires an x-ray beam with very little coherence and is thus compatible with high wafer throughput schemes; in addition, image fidelity remains high even when moderately small contaminant particles block the light from small regions of the hologram. Fabrication limits for the single optic involved-are compatible with current technological limits. The approach is applicable over a large range of soft-x-ray wavelengths, indicating the feasibility of a 100 nm resolution system with 6 pm depth of field using a carbon mask ‘system operating at 5 nm, or other materials at shorter wavelengths.
Sustainable Conversion of Lignocellulose to High-Purity, Highly Crystalline Flake Potato Graphite (2018)

The carbon net negative conversion of biochar, the byproduct of pyrolysis bio-oil production from biomass, to very high-purity (99.95%), highly crystalline flake graphite that is essentially indistinguishable from high-grade commercial Li-ion grade graphite, is reported. The flake size of the graphite is determined by the physical dimensions of the metal particles imbedded in the biochar, demonstrated in the range of micrometers to millimeters. "Potato"-shaped agglomerates of graphite flakes result when the flake diameter is in the 1–5 μm range. The process is shown to work with a variety of biomass, including raw lignocellulose (sawdust, wood flour, and corn cob) and biomass components (cellulose and lignin), as well as lignite. The synthesis is extremely rapid and energy efficient (0.25 kg/kWh); the graphite is produced with a very high yield (95.7%), and the energy content of its coproduct, bio-oil, exceeds that needed to power the process. The demonstrated process is a tremendous advance in the sustainability of graphite production, currently commercially mined or synthesized with very high environmental impacts, and results in a value-added product that could economically advantage carbon-neutral bio-oil production.
High Q two dimensional defect resonators-measured and simulated (2002)

The concept of electromagnetic bandgaps (EBG) was utilized to develop a high Q resonator that can be integrated monolithically with other components due to a reduced height, planar design. The resonator was created by removing a single element in a periodic lattice. Both dielectric and metallo-dielectric lattices have been analyzed, with resulting unloaded Q's of 700 and up to 983, respectively. Finally, a 1% filter at approximately 11.75 GHz was simulated to demonstrate a potential application of this technology.
Self assembly and hydrogelation of spermine functionalized aromatic peptidomimetics against planktonic and sessile methicillin resistant S. aureus (2016)

Novel spermine conjugated shortest nanofibres <bold>NF-3</bold> and <bold>NF-4</bold> showed potent activity against clinically relevant MRSA with a membrane disruptive mode of action.
Spectral line-by-line pulse shaping for optical arbitrary pulse-train generation (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Zhi Jiang, Chen-Bin Huang, Daniel E. Leaird, and Andrew M. Weiner, "Spectral line-by-line pulse shaping for optical arbitrary pulse-train generation," J. Opt. Soc. Am. B 24, 2124-2128 (2007) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Synthesis of 1′-<i>C</i>-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors (2015)

Ribose modified 1'-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbrüggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.
MicroRNA signature identifies tissue origin of primary and metastatic tumors (2008)

11028 Background: MicroRNAs are a novel class of non-coding, regulatory RNA genes which are involved in oncogenesis and show remarkable tissue-specificity. Their potential for tumor classification suggests they may be applied for identifying tissue-origin of cancers of unknown primary (CUP), a major clinical problem accounting for 3%∼5% of new cancer cases. We have developed a platform for the discovery and development of microRNA-based diagnostic tests. Here we report on the application of this platform for developing a microRNA signature that successfully identifies the tissue origin of primary as well as metastatic tumors. Methods: We developed protocols for extraction of high-quality RNA that retain the microRNA fraction from FFPE archival tissue samples. A microarray platform was used for high-throughput measurement of microRNA expression levels in tumor samples, and a highly specific qRT-PCR platform was used to validate biomarkers. Results: MicroRNA expression profiles were measured in 205 primary and 131 metastatic tumor samples representing 22 distinct tumor types and origins. Samples were divided into a training set (3/4) and a blinded test set (1/4). We developed a transparent classification approach based on 48 microRNAs, each linked to specific differential diagnosis roles. In an independent test of the 83 blinded samples, two-thirds of the samples were classified with high-confidence with an overall accuracy of 89%. Classification accuracy reached 100% for most tissue classes, including for the metastatic tumors. We further validated the significance of these microRNA biomarkers by qRT-PCR using 65 new blinded test samples. Conclusions: We developed a potent and highly accurate microRNA-based algorithm for identifying tissue origin of tumors. The high tissue specificity of microRNAs permits the identification of tumor origin of metastases and primary tumors, based on a small number of microRNAs, and can be used as a new tool in molecular diagnostics of cancer and in particular for identifying tumor origin in CUP. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Rosetta Genomics Ltd Rosetta Genomics Ltd
Urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 as early biomarkers of acute kidney injury and renal recovery following cardiac surgery (2014)

Difficulties in prediction and early identification of acute kidney injury (AKI) have hindered the ability to develop preventive and therapeutic measures for this syndrome. We tested the hypothesis that a urine test measuring insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers of G1 cell cycle arrest, a key mechanism implicated in AKI, could predict AKI in cardiac surgery patients.
Relationship between the microscopic morphology and the charge transport properties in poly(3-hexylthiophene) field-effect transistors (2006)

We fabricate field-effect transistors (FETs) by depositing a regioregular poly(3-hexylthiophene) (RR-P3HT) active layer via different preparation methods. The solvent used in the polymer film deposition and the deposition technique determine the film microstructure, which ranges from amorphous or granular films to a well-defined fibrillar texture. The crystalline ordering of RR-P3HT into fibrillar structures appears to lead to optimal FET performances, suggesting that fibrils act as efficient “conduits” for the charge carrier transport. Treating the silicon oxide gate insulator with hexamethyldisilazane enhanced the FET performance.
Timing driven placement using complete path delays (1990)

The Timing Drive Placement (TDP) system balances wirability and timing constraints so that the final released design meets timing criteria. This is achieved by dynamically evaluating the timing of critical paths during placement. TDP is significant because convergence to a timed wirable solution early in the physical design cycle is achieved, or else it becomes apparent that logic changes are required.
Validating IC early-failure simulation (1995)

Early failures are the dominant concern as integrated circuit technology matures into consistently producing systems of high reliability. These failures are attributed to the presence of randomly occurring defects in elementary objects (contacts, vias, metal runs, gate oxides, bonds etc.) that result in extrinsic rather than intrinsic (wearout-related) mortality. A model relating system failure to failure at the elementary objective level has been developed. Reliability is modeled as a function of circuit architecture, mask layout, material properties, life-test data, worst-case use-conditions and the processing environment. The effects of competing failure mechanisms and the presence of redundant sub-systems are accounted for. Hierarchy is exploited in the analysis, allowing large scale designs to be simulated. Experimental validation of the modeling of oxide leakage related failure, based on correlation between actual failures reported for a production integrated circuit and Monte Carlo simulations that incorporate wafer-level test results and process defect monitor data, is presented. The state of the art in IC reliability simulation is advanced in that a methodology that provides the capability to design-in reliability while accounting for early failures has been developed; applications include process qualification, design assessment and fabrication monitoring.
Some Properties of Multiple-Antenna-Port and Multiple-User-Port Antenna Tuners (2014)

A user port impedance range and a user port tuning range characterize an antenna tuner at a given frequency. These sets and their local dimensions are defined and studied for an antenna tuner having any number n of antenna ports and any number m of user ports. A reciprocal antenna tuner is said to have a full tuning capability if it can provide or compensate all relevant small impedance variations, under the assumption that its adjustable impedance devices can provide suitable reactance values. For reciprocal antennas and a reciprocal antenna tuner, it is proven that the local dimension of the user port impedance range is equal to m(m+1) if and only if the antenna tuner has a full tuning capability. We use this result to study an antenna tuner made of several uncoupled single-antenna-port and single-user-port antenna tuners. We also use this result to show that a new multiple-antenna-port and multiple-user-port antenna tuner has a full tuning capability.
Highly reliable and mode-stabilized (GaAl)As double-heterostructure visible lasers on p-GaAs substrate (1981)

A new channeled-substrate (GaAl)As double-heterostructure (DH) visible laser on p-GaAs, called a V-channeled Substrate Inner Stripe (VSIS) laser, has been developed. A built-in optical waveguide and internal current confinement are realized in the structure. The lasers with emission wavelength of 760-790 nm reproducibly provide a single mode operation up to 20 mW/facet cw. For (GaAl)As visible lasers, Te is usually used as a dopant in the n-type cladding layer. This Te, however, is found to lower the reliability of the conventional oxide-stripe lasers where the active layer is deposited on the Te doped n-type cladding layer, even when the Te concentration is lower than 5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">17</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . On the other hand, the n-type cladding layer is grown on the active layer in the VSIS laser. Consequently, the degradation which arises from the rather poor quality of the Te doped cladding layer is suppressed in the VSIS laser although the Te concentration is as high as 1 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . The VSIS lasers with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\lambda \sim 770</tex> nm have been continuously operating with almost no degradation for 2000 hours at 10 mW/ facet (5 mW/µ m) operation at 50 °C up to the present.
Pyroelectric anemometry: Vector and swirl measurements (1995)

The characteristics of a vector pyroelectric anemometer that measures the orthogonal components of mass flow are presented. This anemometer consists of three measuring electrodes and two heater elements on a 6 mm × 6 mm chip that form two orthogonal linear anemometers. The characteristics of a single pair of electrodes forming an in-line linear anemometer are in good agreement with recent measurements and theory. A wall-mounted vector pyroelectric anemometer is used to measure the decay of swirl in air flowing through a 45 mm inner diameter, 5 m long flow system. The swirl flow is produced by a 90° out-of-plane double elbow at the flow system inlet. The tube flow generated by a squirrel-cage fan has a Reynolds number of ≈ 24 000, well into the turbulent regime. Measurements are conducted at the wall at a uniform distance along the length of the flow section for both straight and swirl flow. The measured decay length is ≈ 40 pipe diameters, in good agreement with measurements on water.