gebhart/patrepeval huggingface dataset:
Ultrafast Ultrasound Imaging as an Inverse Problem: Matrix-Free Sparse Image Reconstruction (2017)

Conventional ultrasound (US) image reconstruction methods rely on delay-and-sum (DAS) beamforming, which is a relatively poor solution to the image reconstruction problem. An alternative to DAS consists in using iterative techniques, which require both an accurate measurement model and a strong prior on the image under scrutiny. Toward this goal, much effort has been deployed in formulating models for US imaging, which usually require a large amount of memory to store the matrix coefficients. We present two different techniques, which take advantage of fast and matrix-free formulations derived for the measurement model and its adjoint, and rely on sparsity of US images in well-chosen models. Sparse regularization is used for enhanced image reconstruction. Compressed beamforming exploits the compressed sensing framework to restore high-quality images from fewer raw data than state-of-the-art approaches. Using simulated data and in vivo experimental acquisitions, we show that the proposed approach is three orders of magnitude faster than non-DAS state-of-the-art methods, with comparable or better image quality.
Silicon Photomultipliers for Deep Tissue Cerenkov Emission Detection During External Beam Radiotherapy (2019)

Cerenkov Emission (CE) during external beam radiation therapy (EBRT) from a linear accelerator (Linac) has been demonstrated as a useful tool for radiotherapy quality assurance and potentially other applications for online tracking of tumors during treatment delivery. However, some of the current challenges that are impacting the potential of CE are related to the limited detection sensitivity and the lack of flexible tools to fit into an already complex treatment delivery environment. Silicon photomultiplier (SiPM) solid-state devices are new promising tools for low light detection due to their extreme sensitivity that mirrors photomultiplier tubes and yet have a form factor that is similar to silicon photodiodes, allowing for improved flexibility in device design that may help in the process of wider clinical applicability. In this work, we assess the feasibility of using SiPMs to detect CE during EBRT from a Linac and contrast their performance with commercially available silicon photodiodes (PDs). We demonstrate the feasibility of the SiPM based probes for standard dosimetry measurements. We also demonstrate that CE optical signals can be detected from tissue depths about five times greater than that for standard probes based on PDs, making our SiPM probe an enabling technology of CE measurements, particularly for deep tissue applications.
Peripheral-Free Device Pairing by Randomly Switching Power (2021)

With the growing popularity of the Internet-of-Things (IoT), a massive amount of purpose-specific, heterogeneous, inexpensive devices have been deployed. To allow these devices to perform their duties and collaborate efficiently, designing a secure and dependable communication channel is necessary. Pairing, as the fundamental procedure for establishing a trustworthy communication channel, has received extensive attention from security researchers. Previous secure pairing protocols depend on auxiliary peripherals (e.g., displays, speakers) to share the secret message, while for those products featuring with low-price, manufacturers would probably adopt insecure pairing methods to reduce the cost, so the devices may be subject to various attacks. To mitigate such a situation, we design a peripheral-free secure pairing protocol, termed SwitchPairing. Our protocol only requires users to connect the pre-pairing devices to the same power source, then randomly presses and releases the switch to generate a shared secret. It does not require additional peripherals and can defense eavesdropping and replay attacks innately. We implement a prototype via two CC2640R2F development boards and invite volunteers to participate in the experiments about bench-marking security and usability. The result of our experiments show that our protocol can fulfill the security and efficient requirement of various IoT applications.
Preferential Adsorption and Selective Permeation of Alcohol/Hydrocarbon Mixtures in Reverse Osmosis (1988)

Abstract In binary mixtures of alcohols and hydrocarbons there are two types of reverse osmosis performances. These are selective permeation of the alcohol and selective permeation of the hydrocarbon. Liquid chromatography results have been used to predict the selective permeation of reverse osmosis membranes where the membranes may be difficult to fabricate as well as to determine performance limits in terms of separation. These results are of interest for the production of oxygenated fuel blending agents where specifications require the removal of unreacted methanol for further processing and distillation is not viable.
Probabilistic Fracture Mechanics Framework Including Crack Nucleation of Rotor Forging Flaws (2019)

Abstract We present a probabilistic rotor life prediction framework that combines the forging flaw crack nucleation process and the subsequent crack growth to failure. Experimental fatigue tests of specimens including forging flaws show that the life cycle of a forging flaw can be described by a nucleation phase followed by a fatigue crack growth phase. These results demonstrate that the nucleation phase is a significant fraction of the whole life cycle to failure. However, as there is no engineering method available that describes reliably the nucleation phase, this portion is oftentimes neglected in engineering life prediction frameworks, therefore resulting in a conservative life quantification. In order to improve probabilistic life quantification methods, we introduce a rigorous scheme that convolutes the local crack nucleation probabilities and the local crack growth failure probabilities in order to provide a local failure probability. Integration over the whole component then yields the total probability of failure for the engineering part under a specific load spectrum. A specific direct simulation Monte Carlo numerical implementation is demonstrated. It is applied to fatigue crack nucleation from large gas turbine rotor disk forging flaws followed by crack growth to component failure. For different regions of the analyzed rotor components, the results show the probabilistic interplay of the different temperature and stress dependences of the applied empirical nucleation models and the fatigue crack growth models. The presented probabilistic approach is generic and not restricted to the discussed fatigue nucleation and subsequent crack growth process in large rotor forgings. The framework can be applied to a variety of sequential failure processes including static and fatigue loading phenomena, as well as a multiplicity of failure modes and sequences relevant for engineering components.
Sensitive and Specific Serodiagnosis of Lyme Disease by Enzyme-Linked Immunosorbent Assay with a Peptide Based on an Immunodominant Conserved Region of<i>Borrelia burgdorferi</i>VlsE (1999)

VlsE, the variable surface antigen of Borrelia burgdorferi, contains an immunodominant conserved region named IR(6). In the present study, the diagnostic performance of a peptide enzyme-linked immunosorbent assay (ELISA) based on a 26-mer synthetic peptide (C(6)) with the IR(6) sequence was explored. Sensitivity was assessed with serum samples (n = 210) collected from patients with clinically defined Lyme disease at the acute (early localized or early disseminated disease), convalescent, or late disease phase. The sensitivities for acute-, convalescent-, and late-phase specimens were 74% (29 of 39), 85 to 90% (34 of 40 to 35 of 39), and 100% (59 of 59), respectively. Serum specimens from early neuroborreliosis patients were 95% positive (19 of 20), and those from an additional group of patients with posttreatment Lyme disease syndrome yielded a sensitivity of 62% (8 of 13). To assess the specificity of the peptide ELISA, 77 serum samples from patients with other spirochetal or chronic infections, autoimmune diseases, or neurologic diseases and 99 serum specimens from hospitalized patients in an area where Lyme disease is not endemic were examined. Only two potential false positives from the hospitalized patients were found, and the overall specificity was 99% (174 of 176). Precision, which was assessed with a panel of positive and negative serum specimens arranged in blinded duplicates, was 100%. Four serum samples with very high anti-OspA antibody titers obtained from four monkeys given the OspA vaccine did not react with the C(6) peptide. This simple, sensitive, specific, and precise ELISA may contribute to alleviate some of the remaining problems in Lyme disease serodiagnosis. Because of its synthetic peptide base, it will be inexpensive to manufacture. It also will be applicable to serum specimens from OspA-vaccinated subjects.
Body composition modeling in the calf using an equivalent circuit model of multi-frequency bioimpedance analysis (2005)

An equivalent electrical circuit model is used to describe the response of different tissue components in the calf to multi-frequency current. This model includes seven electrical components: skin resistance, contact capacitance, fat resistance, fat capacitance, extracellular resistance, intracellular resistance and cell membrane capacitance. Calf bioimpedance was measured on 30 pts using a multi-frequency bioimpedance device (Xitron 4200) with a range of frequency from 5 kHz to 1000 kHz. MRI was performed on each measured calf to provide body composition components: fat, muscle mass and bone. An equivalent circuit containing seven parameters (P1, P2, P3, P4, Q1, Q2, Q3) was constructed to represent the model. To identify the effect of different body compositions on their parameters, subjects were subgrouped according to (1) their range of fat mass: F1>0.4 kg, F2>0.4 & F2<0.25 kg and F3<0.25 kg; (2) their range of muscle mass: M1>1.2 kg, M2<1.2 & M2>1.0 kg and M3<0.25 kg. Curve fitting and simulation programs (Matlab Toolbox) were used to obtain the solution of the electrical equations. The results show a decrease in impedance with an increase in excitation frequency that differed among subjects with different fat contents. Simulation results show a high correlation (R2>0.98) between the bioimpedance measurements and the value calculated from the model. There are significant differences in parameters P1 (32.5+/-5.9 versus 26+/-4.4, p<0.05), P3 (-15,330+/-3352 versus -10,973+/-3448, p<0.05) and P4 (42,640 versus 24,191, p<0.05) between groups F1 and F3. P2 is significantly different (1045+/-442 versus 1407+/-349, p<0.05) between groups M1 and M2. The parameters that characterize the bioimpedance data depend upon many more tissue characteristics of electrical properties than those incorporated in current models and they are affected by aspects of body composition that are not considered in the fitting of bioimpedance data. This study shows a new model and methodology to analyze bioimpedance data and further work is likely to lead to much better understanding of electrical properties of body tissue.
Turbine - Generator on-Line Diagnostics Using RF Monitoring (1981)

An EPRI-Westinghouse funded program to develop turbine-generator on-line diagnostics through monitoring of a generator's neutral radio frequency current has produced an on-line RF monitor. It is designed to detect internal generator arcing and alert the operator if the arcing level becomes destructively high.
Surface Plasmon Resonance Imaging Measurements of Biomolecular Arrays (2008)

Abstract Originally published in: Protein Microarray Technology. Edited by Dev Kambhampati. Copyright © 2004 Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3‐527‐30597‐1 The sections in this article are Introduction Surface Plasmon Resonance Imaging Surface Attachment Chemistries SSMCC Attachment Chemistry SATP Attachment Chemistry SPR Imaging Experiments Using Photopatterned Arrays DNA – DNA Hybridization Mismatch Binding Protein, Mut S Bacterial Response Regulators, Omp R and Van R SPR Imaging Experiments of Arrays Created by Microfluidic Stencils 1‐D Peptide Array for Antibody Binding Measurements 2‐D DNA Array for RNA Hybridization 2‐D Peptide Array for Antibody Binding Measurements 2‐D Protein Array Conclusions Acknowledgments
Translating intracarotid artery transplantation of bone marrow-derived NCS-01 cells for ischemic stroke: Behavioral and histological readouts and mechanistic insights into stem cell therapy (2019)

The present study used in vitro and in vivo stroke models to demonstrate the safety, efficacy, and mechanism of action of adult human bone marrow-derived NCS-01 cells. Coculture with NCS-01 cells protected primary rat cortical cells or human neural progenitor cells from oxygen glucose deprivation. Adult rats that were subjected to middle cerebral artery occlusion, transiently or permanently, and subsequently received intracarotid artery or intravenous transplants of NCS-01 cells displayed dose-dependent improvements in motor and neurological behaviors, and reductions in infarct area and peri-infarct cell loss, much better than intravenous administration. The optimal dose was 7.5 × 10<sup>6</sup> cells/mL when delivered via the intracarotid artery within 3 days poststroke, although therapeutic effects persisted even when administered at 1 week after stroke. Compared with other mesenchymal stem cells, NCS-01 cells ameliorated both the structural and functional deficits after stroke through a broad therapeutic window. NCS-01 cells secreted therapeutic molecules, such as basic fibroblast growth factor and interleukin-6, but equally importantly we observed for the first time the formation of filopodia by NCS-01 cells under stroke conditions, characterized by cadherin-positive processes extending from the stem cells toward the ischemic cells. Collectively, the present efficacy readouts and the novel filopodia-mediated mechanism of action provide solid lab-to-clinic evidence supporting the use of NCS-01 cells for treatment of stroke in the clinical setting.
A Kalman filter based restoration method for in-vehicle camera images in foggy conditions (2008)

This paper proposes a Kalman filter based restoration method for images obtained by in-vehicle camera in foggy conditions. The proposed method introduces two novel approaches into the Kalman filter based restoration. The first one is an automatic determination of a fog deterioration model. A vanishing point in the foggy image is estimated by using cross ratio of lane marking, and automatic determination of all parameters of the fog deterioration model is realized. Furthermore, the obtained model is introduced into the Kalman filter. Specifically, our method regards each frame as a state variable and its observation model is defined by the fog deterioration model. Then, since the correlation between successive frame can be effectively utilized by the Kalman filter, the accurate restoration of foggy images is achieved. Experimental results show that the proposed method achieves higher performance than the traditional method based on the fog deterioration model.
Heat-seeking honeypots (2011)

Many malicious activities on the Web today make use of compromised Web servers, because these servers often have high pageranks and provide free resources. Attackers are therefore constantly searching for vulnerable servers. In this work, we aim to understand how attackers find, compromise, and misuse vulnerable servers. Specifically, we present heat-seeking honeypots that actively attract attackers, dynamically generate and deploy honeypot pages, then analyze logs to identify attack patterns.
Elaboration of a cellularizable chitosan based hydrogel and pre-requisites for implantation (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
A high-frequency decimal multiplier (2004)

Decimal arithmetic is regaining popularity in the computing community due to the growing importance of commercial, financial, and Internet-based applications, which process decimal data. This paper presents an iterative decimal multiplier, which operates at high clock frequencies and scales well to large operand sizes. The multiplier uses a new decimal representation for intermediate products, which allows for a very fast two-stage iterative multiplier design. Decimal multipliers, which are synthesized using a 0.11 micron CMOS standard cell library, operate at clock frequencies close to 2 GHz. The latency of the proposed design to multiply two n-digit BCD operands is (n+8) cycles with a new multiplication able to begin every (n+1) cycles.
A multiplexed nanostructure-initiator mass spectrometry (NIMS) assay for simultaneously detecting glycosyl hydrolase and lignin modifying enzyme activities (2021)

Lignocellulosic biomass is composed of three major biopolymers: cellulose, hemicellulose and lignin. Analytical tools capable of quickly detecting both glycan and lignin deconstruction are needed to support the development and characterization of efficient enzymes/enzyme cocktails. Previously we have described nanostructure-initiator mass spectrometry-based assays for the analysis of glycosyl hydrolase and most recently an assay for lignin modifying enzymes. Here we integrate these two assays into a single multiplexed assay against both classes of enzymes and use it to characterize crude commercial enzyme mixtures. Application of our multiplexed platform based on nanostructure-initiator mass spectrometry enabled us to characterize crude mixtures of laccase enzymes from fungi Agaricus bisporus (Ab) and Myceliopthora thermophila (Mt) revealing activity on both carbohydrate and aromatic substrates. Using time-series analysis we determined that crude laccase from Ab has the higher GH activity and that laccase from Mt has the higher activity against our lignin model compound. Inhibitor studies showed a significant reduction in Mt GH activity under low oxygen conditions and increased activities in the presence of vanillin (common GH inhibitor). Ultimately, this assay can help to discover mixtures of enzymes that could be incorporated into biomass pretreatments to deconstruct diverse components of lignocellulosic biomass.
TEOM(trade mark) real-time carbon-concentration monitor. Final report (1986)

This report documents the findings of a project aimed at adapting an existing particulate, mass-measuring device for quick, on-line determinations of the amount of carbon in fly ash. The presence of carbon reduces the efficiency of boilers and decreases the marketability of fly ash. Fly ash is typically used to stabilize certain coal waste products and in building materials. The market value of fly ash as a recyclable waste is inversely proportional to its carbon content. The system was successfully tested on-line at the Rochester Gas and Electric Corporation's Russel Station. Coal-fired utilities could use this instrument, capable of diagnostic and continuous monitoring to help burn coal more efficiently and reduce carbon concentrations in emissions. Included in the report are a description of the Real-Time Mass Measurement -- TEOM(TM), oxidation studies, filter and heater-design operation data and laboratory and on-site measurements of operations.
Multicast Cloud with Integrated Multicast and Unicast Content Distribution Routing (2006)

In this paper, we describe the concept and design of “application-layer multicast cloud,” the first overlay network design that provides integrated content distribution routing between IP multicast and unicast via a user-configured group of multicast senders and receivers for content distribution across different layer-3 IP multicast groups, content distribution channels, and unicast distribution relay trees, that for the first time allows for application-layer (as opposed to layer-3 or layer-4) control of multicast security, failover, QoS, and bandwidth utilization. None of these were possible before and yet the need for such capabilities is great in Content Distribution Network (CDN) deployments. Note that here “multicast cloud” refers to an “application-layer” user configured entity with (1) a number of properties that govern the IP multicast flow and the interaction between multicast and unicast content distribution, and (2) a set of hosts that can participate in multicast content replication that happens on multiple layer-3 IP multicast groups and across multiple layer-3 IP multicast islands.
Inactivation of both <i>APC</i> alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP) (1992)

To examine whether the dosage effect of germ-line mutations in patients with familial adenomatous polyposis (FAP) is sufficient to cause colorectal adenomas, or an additional somatic mutation of the normal allele is required as well, we have investigated somatic mutations of the APC gene in multiple adenomas developed in one FAP patient. In addition to a 5-bp deletion of one allele present constitutionally in this patient, the normal APC allele had been lost in five of seven DNA samples extracted from small adenomas (< 3 mm in diameter) with mild or moderate atypia. This result indicates that the inactivation of both alleles of the APC gene is probably essential for the development of an early-stage adenoma, in agreement with the two-hit mutational model underlying the concept of tumor suppressor genes.
High Affinity Ligand Binding by Integrins Does Not Involve Head Separation (2003)

Conformational change in the integrin extracellular domain is required for high affinity ligand binding and is also involved in post-ligand binding cellular signaling. Although there is evidence to the contrary, electron microscopic studies showing that ligand binding triggers alpha- and beta-subunit dissociation in the integrin headpiece have gained popularity and support the hypothesis that head separation activates integrins. To test directly the head separation hypothesis, we enforced head association by introducing disulfide bonds across the interface between the alpha-subunit beta-propeller domain and the beta-subunit I-like domain. Basal and activation-dependent ligand binding by alpha(IIb)beta(3) and alpha(V)beta(3) was unaffected. The covalent linkage prevented dissociation of alpha(IIb)beta(3) into its subunits on EDTA-treated cells. Whereas EDTA dissociated wild type alpha(IIb)beta(3) on the cell surface, a ligand-mimetic Arg-Gly-Asp peptide did not, as judged by binding of complex-specific antibodies. Finally, a high affinity ligand-mimetic compound stabilized noncovalent association between alpha(IIb) and beta(3) headpiece fragments in the presence of SDS, indicating that ligand binding actually stabilized subunit association at the head, as opposed to the suggested subunit separation. The mechanisms of conformational regulation of integrin function should therefore be considered in the context of the associated alphabeta headpiece.