gebhart/patrepeval huggingface dataset:
LazyBase (2012)

The LazyBase scalable database system is specialized for the growing class of data analysis applications that extract knowledge from large, rapidly changing data sets. It provides the scalability of popular NoSQL systems without the query-time complexity associated with their eventual consistency models, offering a clear consistency model and explicit per-query control over the trade-off between latency and result freshness. With an architecture designed around batching and pipelining of updates, LazyBase simultaneously ingests atomic batches of updates at a very high throughput and offers quick read queries to a stale-but-consistent version of the data. Although slightly stale results are sufficient for many analysis queries, fully up-to-date results can be obtained when necessary by also scanning updates still in the pipeline. Compared to the Cassandra NoSQL system, LazyBase provides 4X--5X faster update throughput and 4X faster read query throughput for range queries while remaining competitive for point queries. We demonstrate LazyBase's tradeoff between query latency and result freshness as well as the benefits of its consistency model. We also demonstrate specific cases where Cassandra's consistency model is weaker than LazyBase's.
Substrate specificities of the protease of mouse serum Ra-reactive factor. (1995)

Ra-reactive factor (RaRF) is a serum bactericidal factor whose function seems to be to activate C in a manner similar to that of C1, but with activation triggered by binding to bacterial polysaccharides instead of to immune complexes. It is composed of multiple polysaccharide-binding subunits associated with a novel serine protease, and its overall structural organization is similar to that of C1. This similarity extends to the serine protease component, which shares a similar modular construction and about 40% sequence identity with the C1r and C1s subcomponents of C1. In this study, we examined the substrate specificity of mouse RaRF by assaying its ability to cleave C components C3, C4, and C5, and its activity against the murine C4 isotype, sex-limited protein. Our results revealed that RaRF preferentially cleaves the C4 alpha-chain with specific activities 20- to 100-fold greater than either human or murine C1s, and that RaRF also cleaves the C3 alpha-chain, but with a lower efficiency than C4 alpha. We also found that RaRF is much less sensitive than C1s to mutations near the proteolytic site and that the two proteases show different reactivities against synthetic substrates. Hence, although the RaRF protease and C1s have similar structures and play similar roles in C activation, they also display clear differences in substrate range and in the details of their substrate recognition mechanisms. Finally, we found that RaRF does not cleave sex-limited protein even at a level 100-fold higher than necessary for C4 cleavage.
Development and evaluation of male-only strains of the Australian sheep blowfly, Lucilia cuprina (2014)

The Australian sheep blowfly Lucilia cuprina (Wiedemann) is a major pest of sheep in Australia and New Zealand. From the 1960s to the 1980s there was a major effort to develop "field female killing" or FFK strains of L. cuprina that could be used for a cost-effective genetic control program. The FFK strains carried eye color mutations that were lethal to females in the field but not under conditions in the mass rearing facility. Males did not die in the field as normal copies of the eye color genes had been translocated to the Y chromosome and an autosome. Although the FFK strains showed some promise in field tests, a genetic control program in mainland Australia was never implemented for several reasons including instability of the FFK strains during mass rearing. A stable transgenic strain of L. cuprina that carried one or more dominant repressible female lethal genes offered the potential for efficient genetic control of blowfly populations. Here I review our research on tetracycline-repressible female lethal genetic systems, Lucilia germ-line transformation and sex determination genes that ultimately led to the successful development of transgenic "male-only" strains of L. cuprina. The technology developed for L. cuprina should be directly transferable to other blowfly livestock pests including L. sericata and the New World and Old World screwworm. 29.
Field Development Plans Optimization by Modeling Fluids Flow Impact and Assessing Intelligent Wells on Reservoir Performance (2008)

Abstract The understanding and accuracy of modeling fluid flow behavior in naturally fractured carbonate reservoir is critical in predicting reservoir sweep efficiency, remaining drilling targets and evaluating field development alternatives. The use of appropriate complex wells design such as Horizontals, (H) Multi-laterals (ML) and completion technology such as equalizers (ICD) or Inflow Control Valves (ICV) are of equal importance. The approach presented in this paper is based on detailed integrated analysis of all available well data including logs, production, pressure transient analysis (PTA), fracture distributions, well flow profiles (PLT) etc, to provide a first-line insight of the fractured reservoir fluid flow mechanism. These first-line insights provide the basis to develop mechanistic or concept reservoir simulation models to fine-tune fluid movement understanding in fractures, reservoir matrix, well types (H, ML) and completion placement to field development strategies. Sector modeling provides further insight to well design in field areas of different rock quality and fracture density. Well type and completion strategy alternatives for each identified field area including intelligent smart well completions are developed and tested in each sector model. The combined developed understanding of fluid flow mechanisms, well type and completion strategy are rolled up and implemented into a full field simulation model, fine tuned through history match and prediction processes. This paper describes the methodology used to study a number of naturally fractured carbonate reservoirs through the integrated "Event Solution"1 study approach. The methodology presented in this paper was applied on a number of large Middle East carbonate fields. The fields studied have naturally fractured reservoirs with two distinct fracture systems. Namely, fracture corridors or clusters and diffuse or layer-bounded fractures. Diffuse fractures are typically horizontal (layer-bounded fractures) inter-connect with the fracture corridors which are normally vertical to sub-vertical. This fracture system combination forms a highly conductive fluid flow and pressure medium which is responsible for observed water movement as well as pressure propagation from the aquifer/injectors into the reservoirs.
Continuity of Graphene on Polycrystalline Copper (2010)

The atomic structure of graphene on polycrystalline copper substrates has been studied using scanning tunneling microscopy. The graphene overlayer maintains a continuous pristine atomic structure over atomically flat planes, monatomic steps, edges, and vertices of the copper surface. We find that facets of different identities are overgrown with graphene's perfect carbon honeycomb lattice. Our observations suggest that growth models including a stagnant catalytic surface do not apply to graphene growth on copper. Contrary to current expectations, these results reveal that the growth of macroscopic pristine graphene is not limited by the underlying copper structure.
Multiple plant growth regulator use on short staple cotton. (1993)

A field trial was conducted during the 1992 & 1993 growing seasons to evaluate the activity of Cytokin and Pic applied alone or in combination to short staple cotton. The Cytokin treatment significantly increased tint yield over the other treatments in 1992. There were no statistically significant seed cotton differences between the non - treated check and any treatment in 1993. Fruit retention remained high throughout 1992 and very high throughout the 1993 season. Under high fruiting conditions, use of a plant growth regulator would not normally be recommended.
Feasibility Study of Network Hydraulic Fracture Applied to the Fissured Competent Sand Oil Reservoir (2016)

<span style="font-size: medium; font-family: Calibri;">Chang 8 oil deposit, developed in Hohe and Jihe oil fields at the southern Yi-Shan Slop of Ordos Basin, is regarded as a kind of typical sand reservoir formation with super-low porosity, poor permeability, strong anisotropy as well as locally natural faults and fractures. The previous studies believed that matrix reservoir has a good permeability, whereas fracture reservoir has a reverse manner. In the past years, there have been fewer researches on studying matrix-fracture type oil reservoir; therefore, up to now, it has been still difficult to identify whether network hydraulic fracturing can be effectively exploited in low permeable matrix-fracture type reservoir. In this paper, the author tries to analyze the feasibility of network hydraulic fracturing application in Chang 8 oil deposit from aspects such as mineral component, rock brittleness index, and development status of natural fractures, ground stress, and net press during hydraulic fracturing. The statistical results indicate that the geological condition of the research object is confirmed to meet the standard of hydraulic fracturing with a quartz content of about 40.0% to 41.6%, a brittleness index of 42.6% to 54.6%, a high angle or bevel fracture with a fracture density of 0.03 to 2.6 crack per meter, a mean of 0.38 crack per meter of developed natural fracture and horizontal layers, and the difference of two principal horizontal stresses of 2.8 to 5.5 MPa. Therefore, a certain degree of complex fractures can be built by the methods of segmental perforation, interference between multiple clusters, and the increased net pressure. Finally, we concluded that it is an important treatment to effectively develop this type of oil reservoirs by network hydraulic fracture technology in horizontal wells.</span>
Indigenous recombinant streptokinase Vs natural streptokinase in acute myocardial infarction patients: Phase III multicentric randomized double blind trial (2005)

BACKGROUND: Streptokinase is the most widely used thrombolytic agent and can now be made using recombinant DNA technology.The present trial was initiated to assess an indigenous recombinant streptokinase (Shankinase, r-SK).AIM: To compare the efficacy and safety of indigenous recombinant streptokinase (Shankinase, r-SK) and natural streptokinase (Streptase, n-SK).SETTINGS AND DESIGN: Double blind, randomized, non-inferiority, multicentric, parallel study.MATERIALS AND METHODS: Patients of AMI < 6 hours of chest pain and 2 mm ST elevation in 2 contiguous chest leads V 1 -V 6 or 1 mm in limb leads were randomized to receive 1.5 miu of either r-SK or n-SK.CK Peaking and decrease of >50% ST segment were used to assess reperfusion.STATISTICAL ANALYSIS: Difference in the groups was assessed by chisquare or paired t test as required.Probability value <0.05 was considered significant with 95% confidence interval.RESULTS: Overall 150 patients were recruited (96 r-SK group and 54 in n-SK group) and demographic and clinical profile of the groups was comparable.Reperfusion was seen in 68.2% (58) and 69.4% (34) patients in r-SK and n-SK groups respectively.Commonly seen adverse events were fever in 7 (8.5%),hypotension in 3 (3.6%),nausea in 2 (2.4%) patients.Minor bleeding were seen in 4 (4.8%) of patients.CONCLUSION: Indigenous recombinant Streptokinase (r-SK) is as efficacious as natural streptokinase (n-SK) in establishing reperfusion as assessed by non-invasive parameters with comparable side effect profile.
Interoperability of PDC with GSM (2002)

Currently many countries employ GSM as their cellular systems. In Japan, a PDC cellular system has been introduced. The number of PDC users is increasing significantly, and some PDC users need to roam to a GSM network and vice versa. However, there are some technical incompatibilities between PDC and GSM. Deployment of an IWF (interworking function), which mainly deals with PDC MAP/GSM MAP protocol conversion, would enable roaming between PDC and GSM. Major technical study issues include mobility management, security management and so on. Smart card roaming is regarded as a feasible solution under the different air interfaces. This paper concludes that roaming between PDC and GSM is possible, and will bring great benefit to users.
Anti-Stokes laser cooling in Yb^3+-doped KPb_2Cl_5 crystal (2002)

We report internal laser cooling in Yb(3+) -doped KPb(2)Cl(5) . From the quantum efficiency values measured in the heating and cooling regions by use of the photothermal deflection technique, we have obtained a room-temperature cooling efficiency of 0.2% in a sample doped with ~5x10(19)ions/cm(3) . Excitation spectra obtained under high irradiation fluences show an excess of fluorescence with regard to those obtained at low fluences, which agrees with the prediction of a model based on photon-ion-phonon interaction.
A new collimator for cardiac tomography: the quadrant slant-hole collimator. (1982)

A quadrant slant-hole (QSH) collimator was constructed for myocardial perfusion tomography on a 15-inch large-field gamma camera. This system optimizes the crystal area for multiple-view photon detection while at the same time offering excellent tomographic performance. In addition to the advantages associated with parallel slant-hole collimation, this system's four orthogonal views provide a solution to the problem of patient positioning, namely, proper alignment of the long axis of the left ventricle to the camera. Rapid data acquisition, together with fast reconstruction, make the QSH system a practical approach to tomographic imaging of the myocardium.
Re-evaluation of the Role of Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) in Cellular Calcium Signaling (2012)

Changes in cytoplasmic Ca(2+) concentration, resulting from activation of intracellular Ca(2+) channels within the endoplasmic reticulum, regulate several aspects of cellular growth and differentiation. Ca(2+) homeostasis endoplasmic reticulum protein (CHERP) is a ubiquitously expressed protein that has been proposed as a regulator of both major families of endoplasmic reticulum Ca(2+) channels, inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors (RyRs), with resulting effects on mitotic cycling. However, the manner by which CHERP regulates intracellular Ca(2+) channels to impact cellular growth is unknown. Here, we challenge previous findings that CHERP acts as a direct cytoplasmic regulator of IP(3)Rs and RyRs and propose that CHERP acts in the nucleus to impact cellular proliferation by regulating the function of the U2 snRNA spliceosomal complex. The previously reported effects of CHERP on cellular growth therefore are likely indirect effects of altered spliceosomal function, consistent with prior data showing that loss of function of U2 snRNP components can interfere with cell growth and induce cell cycle arrest.
Structure of a Substrate Complex of Mammalian Cytochrome P450 2C5 at 2.3 Å Resolution:  Evidence for Multiple Substrate Binding Modes<sup>,</sup> (2003)

The structure of rabbit microsomal cytochrome P450 2C5/3LVdH complexed with a substrate, 4-methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide (DMZ), was determined by X-ray crystallography to 2.3 A resolution. Substrate docking studies and electron density maps indicate that DMZ binds to the enzyme in two antiparallel orientations of the long axis of the substrate. One orientation places the principal site of hydroxylation, the 4-methyl group, 4.4 A from the heme Fe, whereas the alternate conformation positions the second, infrequent site of hydroxylation at >5.9 A from the heme Fe. Comparison of this structure to that obtained previously for the enzyme indicates that the protein closes around the substrate and prevents open access of water from bulk solvent to the heme Fe. This reflects a approximately 1.5 A movement of the F and G helices relative to helix I. The present structure provides a complete model for the protein from residues 27-488 and defines two new helices F' and G'. The G' helix is likely to contribute to interactions of the enzyme with membranes. The relatively large active site, as compared to the volume occupied by the substrate, and the flexibility of the enzyme are likely to underlie the capacity of drug-metabolizing enzymes to metabolize structurally diverse substrates of different sizes.
The<i>agouti</i>gene product stimulates pancreatic β-cell Ca<sup>2+</sup>signaling and insulin release (1999)

Ubiquitous expression of the mouse agouti gene results in obesity and hyperinsulinemia. Human agouti is expressed in adipose tissue, and we found recombinant agouti protein to stimulate lipogenesis in adipocytes in a Ca(2+)-dependent fashion. However, adipocyte-specific agouti transgenic mice only became obese in the presence of hyperinsulinemia. Because intracellular Ca(2+) concentration ([Ca(2+)](i)) is a primary signal for insulin release, and we have shown agouti protein to increase [Ca(2+)](i) in several cell types, we examined the effects of agouti on [Ca(2+)](i) and insulin release. We demonstrated the expression of agouti in human pancreas and generated recombinant agouti to study its effects on Ca(2+) signaling and insulin release. Agouti (100 nM) stimulated Ca(2+) influx, [Ca(2+)](i) increase, and a marked stimulation of insulin release in two beta-cell lines (RIN-5F and HIT-T15; P < 0. 05). Agouti exerted comparable effects in isolated human pancreatic islets and beta-cells, with a 5-fold increase in Ca(2+) influx (P < 0.001) and a 2.2-fold increase in insulin release (P < 0.01). These data suggest a potential role for agouti in the development of hyperinsulinemia in humans.
Exchanging tacit community knowledge by talking-virtualized-egos (2000)

Article Free Access Share on Exchanging tacit community knowledge by talking-virtualized-egos Authors: Hidekazu Kubota Graduate School of Information Science, Nara Institute of Science and Technology Graduate School of Information Science, Nara Institute of Science and TechnologyView Profile , Toyoaki Nishida Faculty of Engineering, The University of Tokyo Faculty of Engineering, The University of TokyoView Profile , Tomoko Koda Advanced Research Group, R&D Division, Hakuhodo Inc. Advanced Research Group, R&D Division, Hakuhodo Inc.View Profile Authors Info & Claims AGENTS '00: Proceedings of the fourth international conference on Autonomous agentsJune 2000 Pages 285–292https://doi.org/10.1145/336595.337499Published:01 June 2000Publication History 21citation527DownloadsMetricsTotal Citations21Total Downloads527Last 12 Months14Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Parallel Predictive Entropy Search for Batch Global Optimization of Expensive Objective Functions (2015)

We develop parallel predictive entropy search (PPES), a novel algorithm for Bayesian optimization of expensive black-box objective functions. At each iteration, PPES aims to select a batch of points which will maximize the information gain about the global maximizer of the objective. Well known strategies exist for suggesting a single evaluation point based on previous observations, while far fewer are known for selecting batches of points to evaluate in parallel. The few batch selection schemes that have been studied all resort to greedy methods to compute an optimal batch. To the best of our knowledge, PPES is the first non-greedy batch Bayesian optimization strategy. We demonstrate the benefit of this approach in optimization performance on both synthetic and real world applications, including problems in machine learning, rocket science and robotics.
Intracellular Localization of Cthrc1 Characterizes Differentiated Smooth Muscle (2008)

Our data show that the differentiated smooth muscle cell phenotype is associated with the intracellular localization of noncleaved Cthrc1 despite the presence of a signal peptide. On arterial injury, increased Cthrc1 expression with apparent extracellular localization of N-terminally truncated Cthrc1 occurs. Removal of the propeptide correlated with increased activity of the molecule.
Gut microbiota in hypertension (2015)

The beneficial or deleterious effect of gut microbiota on blood pressure is a consequence of several variables, including genetics, epigenetics, lifestyle, and intake of antibiotics. These variables may influence the ultimate level of blood pressure and control of hypertension.
Oncolytic Viruses Driven by Tumor-Specific Promoters (2007)

Oncolytic viruses can selectively replicate in and lead to tumor cell lysis with minimal infection/replication potential in adjoining non-neoplastic tissue. Because of paramount safety concerns, first-generation oncolytic viruses were designed to be significantly attenuated in their lytic potential. Results from recent clinical trials have revealed the safety of this approach, but have underscored the urgency for design and testing of more tumor-selective and -potent viruses to realize the full therapeutic potential of this revolutionary treatment modality. With the discovery of various molecular/genetic changes associated with neoplasia, tumor-specific transcriptional targeting of viral virulence is being tapped to generate tumor- and tissue-specific variants. This review will focus on the various strategies exploited to generate viruses whose virulence is governed by tumor-specific transcriptional events.
Novel Lipophilic Probe for Detecting Near-Membrane Reactive Oxygen Species Responses and Its Application for Studies of Pancreatic Acinar Cells: Effects of Pyocyanin and L-Ornithine (2014)

In our experimental conditions, the novel probe was more sensitive than 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein (CM-H2DCF) and dihydrorhodamine123 (H2R123) and allowed us to resolve ROS responses to secretagogues, pyocyanin, and L-ornithine. Changes in the fluorescence of the new probe were particularly prominent in the peripheral plasma membrane-associated regions. Our findings suggest that the new probe will be a useful tool in studies of the contribution of ROS to the pathophysiology of exocrine pancreas and other organs/tissues.
Fabrication of carbohydrate microarrays on a poly(2-hydroxyethyl methacrylate)-based photoactive substrate (2015)

We report the fabrication of carbohydrate microarrays on a photoactive polymer, poly(HEMA-co-HEMA-PFPA), synthesized by RAFT copolymerization of 2-hydroxyethyl methacrylate (HEMA) and perfluorophenyl azide (PFPA)-derivatized HEMA (HEMA-PFPA). PFPA allows the covalent immobilization of carbohydrates whereas the HEMA polymer provides an antifouling surface, thus the microarrays can be used directly without pretreating the array with a blocking agent. The microarrays were prepared by spin-coating the polymer followed by printing the carbohydrates. Subsequent irradiation simultaneously immobilized the carbohydrates and crosslinked the polymer matrix. The obtained 3D carbohydrate microarrays showed enhanced fluorescence signals upon treating with a fluorescent lectin in comparison with a 2D microarray. The signals were acquired at a lower lectin concentration and a shorter incubation time. When treated with E. coli bacteria, the carbohydrate microarray showed results that were consistent with their binding patterns.