gebhart/patrepeval huggingface dataset:
The Combination of Solid-State Gyroscopic and Magnetic Surveys Provides Improved Magnetic-Survey Data and Enhanced Survey Quality Control (2019)

Summary The use of advanced solid-state gyroscopic sensors has become both a viable and practical option for high-accuracy wellbore placement, with the potential to outperform traditional mechanical gyroscopic systems. In this paper, we describe how the contributions of the new gyroscope technology are causing service providers to reconsider current survey practices, and to examine how the new gyroscopic-survey tools can best be used for wellbore surveying and real-time wellbore placement. The simultaneous application of multiple survey tools, largely made possible as a result of the unique attributes of solid-state gyroscopic sensors (including small size and significant power reduction), has clear benefits in terms of enhanced well placement, reliability, and the detection of gross errors in the survey process. Further advantages accrue through the combination of different but complementary survey methods. In this paper, we focus mainly on the benefits of combining gyroscopic and magnetic measurements to reduce or remove the known errors related to the Earth's magnetic field to which magnetic-survey systems are susceptible: errors in total magnetic field, declination, and dip angle. In this context, the use of statistical estimation techniques depending on the performance models of the survey systems used is described. For post-drilling surveys (using drop-survey tools or wireline-conveyed tools, for example), post-run analysis of the data using least-squares estimation techniques is appropriate. Alternative methods capable of achieving real-time data correction during drilling are also described, and results are presented to demonstrate the potential for enhanced magnetic-survey performance. The principles described can be used when running basic magnetic measurement-while-drilling (MWD) systems and for systems that use field correction methods, such as the various in-field referencing (IFR) techniques, that are frequently used. The proposed methodology is of particular benefit in the former case, allowing enhanced magnetic surveying to be achieved without the need for expensive and complex magnetic-field correction procedures. The potential also exists either to identify or to correct possible errors in the IFR data when such methods are used. The particular strength of the methods described in this paper is in the estimation and correction of errors in the Earth's magnetic-field parameters while drilling, or after a section of the well has been drilled. Currently, all the magnetic models are dependent on magnetic measurements alone and at the surface or in space. Although there are techniques to estimate the downhole values, such techniques are difficult to quality control (QC) or validate. These updated magnetic-field data allow further sections of the same well, or additional wells in the same region, to be drilled using MWD alone, without the need to use field referencing techniques to achieve accurate well placement. The consequent rig-time and cost savings are expected to be significant.
A Comparison between Polynomial and Locally Weighted Regression for Fault Detection and Diagnosis of HVAC Equipment (2006)

We investigate the accuracy of two predictive modeling methods for the purpose of fault detection and diagnosis (FDD) for HVAC equipment. The comparison is performed within an FDD framework consisting of two steps. In the first step, a predictive regression model is built to represent the dependence of the internal state variables of the HVAC device on the external driving influences, under normal operating conditions. This regression model obtained from training data is used to predict expected readings for state variables, and compute deviations from these readings under various abnormal conditions. The objective of the second step in the FDD framework is to learn to detect abnormalities based on regularities in computed deviations (residuals) from normal conditions. The accuracy of the first step (regression) is essential to the success of this method, since it disambiguates whether variations in observed state variables are due to faults or external driving conditions. In this paper, we present a comparison between locally weighted regression (a local non-linear model) and polynomial regression (a global non-linear model) in the context of fault detection and diagnosis of HVAC equipment. Our experimental results for detection and diagnosis of "overcharged" and "undercharged" refrigerant conditions in an HVAC device show that locally weighted regression clearly outperforms polynomial regression for this task
Abstract 332: Novel Peptide Administered During CPR Improves Long-Term Survival After Prolonged Cardiac Arrest (2019)

Introduction: Cardiac arrest (CA) is a leading cause of death in the United State, affecting 600,000 people annually with overall survival rate of less than 10%. CPR and cooling are the few effective treatments that improve CA survival. No drugs are currently available to improve survival. Active cooling is more effective than targeted temperature management in improving survival, but can be difficult to implement clinically. We have developed a novel peptide (TAT-PHLPP) that inhibits PH domain and Leucine rich repeat Protein Phosphatases (PHLPP). When this peptide was administered intravenously (i.v.) during CPR, it expresses in both heart and brain within 5 min of intravenous injection and significantly improved 4 h survival in a 12 min mouse asystole arrest model. Hypothesis: We hypothesize that TAT-PHLPP improves neurologically intact long-term survival following SCA with improved early metabolic recovery. Methods: C57BL6 mice (n=20) were randomized to receive peptide treatment and appropriate blinding was ensured. A 12 min asystolic arrest was induced with KCl. CPR was started along with TAT-PHLPP (7.5 mg/kg) via i.v. Three day Survival was evaluated. Cerebral blood flow (CBF) and metabolic chemical exchange saturation transfer (CEST) contrast were measured with endogenous and dynamic arterial spin labeling (ASL) and CEST MRI respectively. Glucose utilization was assessed by pyruvate dehydrogenase (PDH) phosphorylation and ATP generation. Further, blood taurine and glutamate were measured. Results: Baseline characteristics including weight, temperature, heart rate, MAP were indistinguishable between the control (normal saline, NS) and peptide group. Compared to NS, TAT-PHLPP significantly improved 3-day survival with better neurological function. It progressively increased CBF and metabolic CEST contrast. It decreased p-PDH (increased activity) at 15 min post-ROSC and enhanced ATP generation in both heart and brain. It also reduced plasma taurine and glutamate concentrations as early as 5 min post-ROSC. Further, high levels of taurine and glutamate were detected in non-survivors. Conclusions: This novel therapy may have a high translational potential to reproduce critical outcomes of CPR cooling without physical cooling.
Misalignment-insensitive wireless power transfer via strongly coupled magnetic resonance principles (2014)

An efficient wireless power transfer (WPT) of strongly coupled magnetic resonance (SCMR) with loops is shown here. This paper shows an optimal 3D loop design for SCMR systems, that is insensitive to misalignment, and exhibits higher efficiency than typical SCMR devices.
Interference subspace rejection in wideband CDMA: modes for mixed-power operation (2002)

Multiuser CDMA detectors suppress interference to provide improved noise immunity, increased capacity, higher data rates and reduced precision requirements for power control. A new multiuser detector structure is formulated which offers a number of implementation modes ranging in performance from that of interference cancellation (IC) detectors to that of linear receivers, yet provides more attractive performance/complexity tradeoffs. It exploits both space and time diversities as well as the array-processing capabilities enabled by multiple antennas and carries out simultaneous channel and timing estimation, signal combining and interference rejection. The improved performance enables increased utilization of wideband CDMA networks, especially at high data rates.
Reversing bone loss by directing mesenchymal stem cells to bone (2013)

Bone regeneration by systemic transplantation of mesenchymal stem cells (MSCs) is problematic due to the inability to control the MSCs' commitment, growth, and differentiation into functional osteoblasts on the bone surface. Our research group has developed a method to direct the MSCs to the bone surface by conjugating a synthetic peptidomimetic ligand (LLP2A) that has high affinity for activated α4β1 integrin on the MSC surface, with a bisphosphonates (alendronate) that has high affinity for bone (LLP2A-Ale), to direct the transplanted MSCs to bone. Our in vitro experiments demonstrated that mobilization of LLP2A-Ale to hydroxyapatite accelerated MSC migration that was associated with an increase in the phosphorylation of Akt kinase and osteoblastogenesis. LLP2A-Ale increased the homing of the transplanted MSCs to bone as well as the osteoblast surface, significantly increased the rate of bone formation and restored both trabecular and cortical bone loss induced by estrogen deficiency or advanced age in mice. These results support LLP2A-Ale as a novel therapeutic option to direct the transplanted MSCs to bone for the treatment of established bone loss related to hormone deficiency and aging.
Real-time Interactive Visualization of Information Hierarchies (2007)

An information hierarchy is a collection of relational information that is arranged in a ranking organization where each entity is subject to a single other entity, except for the top (root) element. The usefulness of a visualization of an information hierarchy depends on its capability of conveying the information quickly and clearly. The interaction with the information hierarchy allows a user to further analyze its underlying structures and relationships, which is essential for the effectiveness of the visualization. In this paper we present a novel method to interactively visualize information hierarchies in real-time. We use the World Wide Web as an application example of our techniques. The result is a novel Web browsing and visualization method with an innovative combination of features: (i) Web data is retrieved and displayed in real-time (i.e. Web data is not pre-recorded), (ii) browsing and visualization are synchronized together in the same interface, (iii) tree-based visualization engine, and (iv) space-efficient display of visualization. Our study shows that users are able to orient themselves better in cyberspace and locate Web pages of interest faster.
The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope Protein (2007)

Hepatitis C virus (HCV) envelope glycoproteins are highly glycosylated, with up to 5 and 11 N-linked glycans on E1 and E2, respectively. Most of the glycosylation sites on HCV envelope glycoproteins are conserved, and some of the glycans associated with these proteins have been shown to play an essential role in protein folding and HCV entry. Such a high level of glycosylation suggests that these glycans can limit the immunogenicity of HCV envelope proteins and restrict the binding of some antibodies to their epitopes. Here, we investigated whether these glycans can modulate the neutralizing activity of anti-HCV antibodies. HCV pseudoparticles (HCVpp) bearing wild-type glycoproteins or mutants at individual glycosylation sites were evaluated for their sensitivity to neutralization by antibodies from the sera of infected patients and anti-E2 monoclonal antibodies. While we did not find any evidence that N-linked glycans of E1 contribute to the masking of neutralizing epitopes, our data demonstrate that at least three glycans on E2 (denoted E2N1, E2N6, and E2N11) reduce the sensitivity of HCVpp to antibody neutralization. Importantly, these three glycans also reduced the access of CD81 to its E2 binding site, as shown by using a soluble form of the extracellular loop of CD81 in inhibition of entry. These data suggest that glycans E2N1, E2N6, and E2N11 are close to the binding site of CD81 and modulate both CD81 and neutralizing antibody binding to E2. In conclusion, this work indicates that HCV glycans contribute to the evasion of HCV from the humoral immune response.
Tunable infrared generation by coherent Raman mixing in H2 (1977)

We have generated continuously tunable infrared output between 3.5 and 13 μm by coherent Raman mixing in H2 gas at 20 atm using a Nd : YAG laser-pumped LiNbO3 parametric oscillator as the input source. The coherent Raman mixing method offers significant advantages over stimulated Raman scattering for frequency conversion.
Review of Nuclear Heating Measurement by Calorimetry in France and USA (2018)

This paper gives a short review of sensors dedicated to measuring nuclear heating rate inside fission reactors in France and USA and especially inside Material Testing Reactors. These sensors correspond to heat flow calorimeters composed of a single calorimetric cell or of two calorimetric cells at least with a reference cell to obtain a differential calorimeter. The aim of this paper is to present the common running principle of these sensors and their own special characteristics through their design, calibration methods, and in-pile measurement techniques, and to describe multi-sensor probes including calorimeters.
Master/slave based optical coherence tomography for <i>in-vivo</i>, real-time, long axial imaging range of the anterior segment (2017)

In this report, we demonstrate that in a coherence revival (CR) based swept source optical coherence tomography (SSOCT) set-up, real-time cross-sectional long-range images can be produced via the Master Slave (MS) method. The total tolerance of the MS method to nonlinear tuning, to dispersion in the interferometer and to dispersion due to the laser cavity, makes the MS ideally suited to the practice of coherence revival. In addition, enhanced versatility is allowed by the MS method in displaying shorter axial range images than that determined by the digital sampling of the data. This brings an immediate improvement in the speed of displaying cross-sectional images at high rates without the need of extra hardware such as graphics processing units or field programmable gate arrays. The long axial range of the coherence revival regime is proven with images of the anterior segment of healthy human eye.
Human antibodies to the 19 kDa C‐terminal fragment of <i>Plasmodium falciparum</i> merozoite surface protein 1 inhibit parasite growth <i>in vitro</i> (1999)

The 19kDa, C-terminal fragment of the major surface protein of Plasmodium falciparum (PfMSP1(19)) is a candidate for inclusion in a subunit malaria vaccine. In this study, we show that PfMSP1(19)-specific antibodies, affinity purified from malaria-immune human serum, can: (i) compete with invasion-inhibitory monoclonal antibodies for binding to PfMSP1(19) and (ii) mediate inhibition of parasite growth in vitro, in the absence of complement and mononuclear cells, at physiological antibody concentrations (100 micrograms/ml). Parasites expressing either the Kl or 3D7 allele of PfMSP1(19) were equally susceptible to inhibition of merozoite invasion, indicating that the target epitopes of inhibitory antibodies are conserved or cross-reactive. These studies suggest that vaccines designed to induce antibodies to PfMSP1(19) may protect against the high levels of malaria parasitaemia which are associated with clinical disease.
CaCo<sub><i>x</i></sub>Zr<sub>1−<i>x</i></sub>O<sub>3−<i>δ</i></sub> Perovskites as Oxygen‐Selective Sorbents for Air Separation (2019)

ABO<sub>3-δ</sub> perovskites are ideal for high-temperature thermochemical air separation for oxygen production because their oxygen nonstoichiometry δ can be varied in response to changes in temperature and oxygen partial pressure [ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>p</mml:mi> <mml:mfenced><mml:msub><mml:mi>O</mml:mi> <mml:mn>2</mml:mn></mml:msub> </mml:mfenced> </mml:mrow> </mml:math> ]. Herein, the outstanding oxygen-sorption performance of CaCo<sub>x</sub> Zr<sub>1-x</sub> O<sub>3-δ</sub> perovskites and their potential application as oxygen-selective sorbents for air separation is reported. In situ thermal X-ray diffraction was used to study the materials' structural changes in response to temperature variations in air and inert atmosphere. Temperature-programmed reduction was employed to elucidate the relationship between perovskite composition and redox property. O<sub>2</sub> sorption performance was evaluated by isothermal analyses at various temperature and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>p</mml:mi> <mml:mfenced><mml:msub><mml:mi>O</mml:mi> <mml:mn>2</mml:mn></mml:msub> </mml:mfenced> </mml:mrow> </mml:math> along with long-term absorption-desorption cycle tests. The high oxygen-sorption capacity was mainly attributed to Co at B-site, whereas partial substitution of Co by Zr enhanced the structural crystallinity and thermal stability of the perovskite. A stable oxygen production of 2.87 wt % was observed at 900 °C during 5 min-sorption cycles for 100 cycles.
Correlation between driving signal reflection on electrodes and performance variation of silicon Mach-Zehnder modulators (2019)

We study the correlations between the driving signal reflection on the traveling wave electrodes and the modulated signal characteristics of silicon Mach-Zehnder modulators (MZM). Correlation coefficients are introduced for systematic and quantitative analysis. The signal-to-noise ratio, extinction ratio, and bit error rate show similar correlation behaviors with the mean reflection magnitude over proper frequency ranges, whereas the correlation behaviors of the temporal parameters can be complex. Partial correlation coefficients can be introduced to help remove the influence of other factors. Some relevant fabrication variation scenarios in the underlying structures are discussed, and potential approaches to mitigating the effects of such variations are suggested.
A spark-plug LDV probe for in-cylinder flow analysis of production IC engines (2005)

Development of a sub-miniature, traversable, two-simultaneous velocity component fibre-optic, laser-Doppler velocimetry (LDV) probe for flow measurements in a production-car IC engine is discussed. The probe is manufactured to fit into an M8 spark-plug hole and it can be traversed 50 mm allowing measurements inside the engine cylinder including the spark-plug location. The probe has been first tested in a steady free round jet and next has been employed on a Honda CIVIC LX car engine for preliminary time-dependent velocity measurements at 10 mm and 36 mm into the engine cylinder. Results indicate lower turbulence intensity values closer to the spark plug than into the engine.
<i>N</i>-Trityl- and <i>N</i>-Phenylfluorenyl-<i>N</i>-carboxyanhydrides and Their Use in Dipeptide Synthesis (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTN-Trityl- and N-Phenylfluorenyl-N-carboxyanhydrides and Their Use in Dipeptide SynthesisTae Bo Sim and Henry RapoportView Author Information Department of Chemistry, University of California, Berkeley, California 94720 Cite this: J. Org. Chem. 1999, 64, 7, 2532–2536Publication Date (Web):March 11, 1999Publication History Received14 September 1998Published online11 March 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/jo981860phttps://doi.org/10.1021/jo981860pbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views906Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Monomers,Nitrogen,Organic compounds,Peptides and proteins,Reaction products Get e-Alerts
NUCLEATION OF CRYSTALS FROM SOLUTION IN MICROGRAVITY USML-1 GLOVEBOX (GBX) INVESTIGATION (1994)

A new method for initiating nucleation from solutions in microgravity which avoids nucleation on container walls and other surfaces is described. This method consists of injecting a small quantity of highly concentrated, heated solution into the interior of a lightly supersaturated, cooler host gowth solution. It was tested successfully on USML-I, producing a large number of LAP crystals whose longest dimension averaged 1 mm.
Monofunctional Carbocyanine Dyes for Bio- and Bioorthogonal Conjugation (2008)

A facile synthetic route to prepare monofunctional carbocyanine dyes for biological application is developed. Three pentamethine carbocyanine dyes have been successfully modified with a variety of functional groups such as: carboxylic acids, azides, or alkynes. The new dyes are characterized by strong NIR fluorescence emission, high extinction coefficients and good quantum yields. The azide and alkyne dyes have potential utility as components in bioorthogonal labeling schemes via [2 + 3] dipolar cycloaddition "click" reactions. The application of one derivative, CyAM-5 alkyne, for bioorthogonal labeling is demonstrated. Fluorescence microscopy shows coupling of CyAM-5 alkyne to Chinese hamster ovary (CHO) cells preincubated with azide modified glycans.
Molecular fractionation with conjugate caps for full quantum mechanical calculation of protein–molecule interaction energy (2003)

A scheme to calculate fully quantum mechanical (ab initio) interaction energy involving a macromolecule like protein is presented. In this scheme, the protein is decomposed into individual amino acid-based fragments that are treated with proper molecular caps. The interaction energy between any molecule and the given protein is given by the summation of interactions between the molecule and individually capped protein fragments. This scheme, termed molecular fractionation with conjugate caps (MFCC), makes it possible and practical to carry out full quantum mechanical (ab initio) calculation of intermolecular interaction energies involving proteins or other similar biological molecules. Numerical tests performed on the interaction energies between a water molecule and three small peptides demonstrate that the MFCC method can give excellent ab initio interaction energies compared to the exact treatment in which the whole peptides are included in the calculation. The current scheme scales linearly with the atomic size of the protein and can be directly applied to calculating real protein–molecule interaction energies by using fully quantum (ab initio) methods that are otherwise impossible. The success of the current method is expected to have a powerful impact in our prediction of protein interaction energies including, e.g., protein–drug interactions.