gebhart/patrepeval huggingface dataset:
The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis. (1986)

In order to establish the nature of the aldosterone synthetase activity in the adrenal cortex, we have used porcine adrenal, bovine adrenal cortex, highly purified bovine and porcine 11 beta-/18-hydroxylase, and antibodies raised against the latter enzyme. Mitochondria from two zones (glomerulosa and fasciculata) of the bovine cortex synthesize aldosterone, but those from glomerulosa are much more active than those from fasciculata. Partially purified (cholate-extracted plus ammonium sulfate-precipitated) extracts of mitochondria from the two zones are equally active in catalyzing all three steps in the conversion of 11-deoxycorticosterone to aldosterone. 18-Hydroxylase and aldehyde synthetase activities (18-hydroxycorticosterone----aldosterone) were completely precipitated from cholate extracts of mitochondria from bovine adrenal by antibodies to the pure porcine enzyme. No activity corresponding to any of the three steps in the conversion of 11-deoxycorticosterone to aldosterone was found in extramitochondrial fractions of the bovine cortex. Synthesis of aldosterone by the pure porcine enzyme was inhibited by antibodies to this enzyme and by metyrapone (an inhibitor of 11 beta-/18-hydroxylase). When fractions of porcine adrenal, resulting from purification of the enzyme from mitochondria, were exhaustively tested for any of the enzyme activities required for the synthesis of aldosterone, activity was found only in those fractions containing the 11 beta-/18-hydroxylase, i.e. no additional enzyme was discarded during the purification procedure. It is concluded that the only adrenocortical enzyme capable of synthesizing aldosterone in bovine and porcine adrenal is the well known 11 beta-hydroxylase, that the conversion of 18-hydroxycorticosterone to aldosterone is catalyzed by this cytochrome P-450, and that this step (aldehyde synthetase) requires the heme of the P-450 as demonstrated by the photochemical action spectrum.
A Pixel-Based Framework for Data-Driven Clothing (2018)

With the aim of creating virtual cloth deformations more similar to real world clothing, we propose a new computational framework that recasts three dimensional cloth deformation as an RGB image in a two dimensional pattern space. Then a three dimensional animation of cloth is equivalent to a sequence of two dimensional RGB images, which in turn are driven/choreographed via animation parameters such as joint angles. This allows us to leverage popular CNNs to learn cloth deformations in image space. The two dimensional cloth pixels are extended into the real world via standard body skinning techniques, after which the RGB values are interpreted as texture offsets and displacement maps. Notably, we illustrate that our approach does not require accurate unclothed body shapes or robust skinning techniques. Additionally, we discuss how standard image based techniques such as image partitioning for higher resolution, GANs for merging partitioned image regions back together, etc., can readily be incorporated into our framework.
Distributed content adaptation for pervasive systems (2005)

Pervasive systems are created by introducing wireless communication into distributed multimedia systems. These systems facilitate mobile data access to applications such as health care, tourism and emergency. However new challenges have emerged that has not been adequately addressed in traditional distributed multimedia systems. In pervasive systems, data must be adapted to the user's preferences, device capabilities and network conditions. Several content adaptation techniques have been proposed to fit the data to the usage environment. In this paper we present a distributed content adaptation framework (DCAF) for distributed multimedia systems and its prototype implementation. The architecture takes into consideration client profile, network conditions, content profile (meta-data) and available adaptation services (third party software elements) to construct an optimal dynamic adaptation graph.
Virtual Reality Welder Training (2005)

Based on the orientation and travel speed of a welding torch, virtual reality technology simulates gas metal arc welding in near-real time using a neural network.
Classically Entangled Vectorial Structured Light towards Multiple Degrees of Freedom and Higher Dimensions (2021)

Vector beam with spin-orbital non-separable coupling acts as classically entangled state with two degrees of freedom, here we generalize the ray-wave structured vectorially structured light to create multi-degree-of-freedom control towards high-dimensional classical entanglement.
A condition-specific codon optimization approach for improved heterologous gene expression in Saccharomyces cerevisiae (2014)

Codon optimization is now often a standard tool for protein expression, and while a variety of tools and approaches have been developed, they do not guarantee improved performance for all hosts of applications. Here, we suggest an alternative method for condition-specific codon optimization and demonstrate its utility in Saccharomyces cerevisiae as a proof of concept. However, this technique should be applicable to any organism for which gene expression data can be generated and is thus of potential interest for a variety of applications in metabolic and cellular engineering.
Correlation of Peripapillary Retinal Height and Visual Field in Glaucoma and Normal Subjects (1995)

We found that peripapillary height, particularly in the temporal region, showed the strongest association with visual field loss in glaucoma patients.
HIGHLY STEREOSELECTIVE PROCEDURE FOR (6<i>R</i>)-TETRAHYDROBIOPTERIN COFACTOR (1984)

Abstract (6R)-Tetrahydrobiopterin cofactor for aromatic amino acid hydroxylases was synthesized stereoselectively by catalytic hydrogenation of biopterin over platinum oxide at pH 11.4 and subsequent crystallization from hydrochloric acid and ethanol.
Effects of Music Aerobic Exercise on Depression and Brain-Derived Neurotrophic Factor Levels in Community Dwelling Women (2015)

A randomized clinical trial was utilized to compare the improvement of depression and brain-derived neurotrophic factor (BDNF) levels between community women with and without music aerobic exercise (MAE) for 12 weeks. The MAE group involved 47 eligible participants, whereas the comparison group had 59 participants. No significant differences were recorded in the demographic characteristics between the participants in the MAE group and the comparison group. Forty-one participants in the MAE group and 26 in the comparison group completed a pre- and posttest. The MAE group displayed significant improvement in depression scores (p = 0.016), decreased depression symptoms in crying (p = 0.03), appetite (p = 0.006), and fatigue (p = 0.011). The BDNF levels of the participants significantly increased after the 12-week MAE (p = 0.042). The parallel comparison group revealed no significant changes in depression scores or BDNF levels. In summary, the 12-week MAE had a significant impact on the enhancement of BDNF levels and improvement of depression symptoms. Middle-aged community women are encouraged to exercise moderately to improve their depression symptoms and BDNF levels.
High-<i>k</i>Gate Dielectrics for Emerging Flexible and Stretchable Electronics (2018)

Recent advances in flexible and stretchable electronics (FSE), a technology diverging from the conventional rigid silicon technology, have stimulated fundamental scientific and technological research efforts. FSE aims at enabling disruptive applications such as flexible displays, wearable sensors, printed RFID tags on packaging, electronics on skin/organs, and Internet-of-things as well as possibly reducing the cost of electronic device fabrication. Thus, the key materials components of electronics, the semiconductor, the dielectric, and the conductor as well as the passive (substrate, planarization, passivation, and encapsulation layers) must exhibit electrical performance and mechanical properties compatible with FSE components and products. In this review, we summarize and analyze recent advances in materials concepts as well as in thin-film fabrication techniques for high- k (or high-capacitance) gate dielectrics when integrated with FSE-compatible semiconductors such as organics, metal oxides, quantum dot arrays, carbon nanotubes, graphene, and other 2D semiconductors. Since thin-film transistors (TFTs) are the key enablers of FSE devices, we discuss TFT structures and operation mechanisms after a discussion on the needs and general requirements of gate dielectrics. Also, the advantages of high- k dielectrics over low- k ones in TFT applications were elaborated. Next, after presenting the design and properties of high- k polymers and inorganic, electrolyte, and hybrid dielectric families, we focus on the most important fabrication methodologies for their deposition as TFT gate dielectric thin films. Furthermore, we provide a detailed summary of recent progress in performance of FSE TFTs based on these high- k dielectrics, focusing primarily on emerging semiconductor types. Finally, we conclude with an outlook and challenges section.
Distributed feedback laser biosensor incorporating a titanium dioxide nanorod surface (2010)

A dielectric nanorod structure is used to enhance the label-free detection sensitivity of a vertically-emitting distributed feedback laser biosensor (DFBLB). The device is comprised of a replica molded plastic grating that is subsequently coated with a dye-doped polymer layer and a TiO2 nanorod layer produced by the glancing angle deposition technique. The DFBLB emission wavelength is modulated by the adsorption of biomolecules, whose greater dielectric permittivity with respect to the surrounding liquid media will increase the laser wavelength in proportion to the density of surface-adsorbed biomaterial. The nanorod layer provides greater surface area than a solid dielectric thin film, resulting in the ability to incorporate a greater number of molecules. The detection of a monolayer of protein polymer poly (Lys, Phe) is used to demonstrate that a 90 nm TiO2 nanorod structure improves the detection sensitivity by a factor of 6.6 compared to an identical sensor with a nonporous TiO2 surface.
WIDE BAND GAP SEMICONDUCTORS. GREAT EXPECTATIONS. (1996)

We will review properties of wide band gap semiconductors, which make them superior materials for many electronic and optoelectronic applications. These semi­ conductors should allow us to achieve a very high on-to-off ratio in transistors, implement nonvolatile solid state memories, and develop new optoelectronic and optical devices for visible and ultraviolet ranges as well as electronic and optoelectronic systems operating in a harsh environment and/or at elevated temperatures. Technological difficulties, relatively low mobility values, and problems related to contacts and traps make the realization of this great potential a challenge. We show that many of these difficulties can be alleviated in AIGaN/GaN Heterostructure Field Effect Transistors (HFETs), which use superior transport properties of the two dimensional electron gas in wide band gap semiconductors. AIGaN/GaN HFET's, which have been fabricated on a transparent sapphire substrate, are very sensitive to ultraviolet light. Hence, they can be also used as solar blind ultraviolet photodetectors.
Cytokines IL-1 β, IL-6, and TNF- α Enhance <i>In Vitro</i> Growth of Bacteria (1999)

We have previously reported that in acute respiratory distress syndrome (ARDS), nonsurvivors have persistent elevation in pulmonary and circulating proinflammatory cytokine levels over time and a high rate of nosocomial infections antemortem. In these patients, none of the proven or suspected nosocomial infections caused a transient or sustained increase in plasma proinflammatory cytokine levels above preinfection values. We hypothesized that cytokines secreted by the host during ARDS may favor the growth of bacteria. We conducted an in vitro study of the growth of three bacteria clinically relevant in nosocomial infections, evaluating their in vitro response to various concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6. We found that all three bacterial species showed concentration-dependent growth enhancement when incubated with one or more tested cytokines and that blockade by specific neutralizing cytokine MoAb significantly inhibited cytokine-induced growth. When compared with control, the 6-h growth response (cfu/ml) was maximal with IL-1beta at 1,000 pg for Staphylococcus aureus (36 +/- 16 versus 377 +/- 16; p = 0.0001) and Acinetobacter spp. (317 +/- 1,147 versus 1,124 +/- 147; p = 0.002) and with IL-6 at 1,000 pg for Pseudomonas aeruginosa (99 +/- 50 versus 509 +/- 50; p = 0.009). The effects of cytokines were seen only with fresh isolates and were lost with passage in vitro on bacteriologic medium without added cytokines. In this study we provide additional evidence for a newly described pathogenetic mechanism for bacterial proliferation in the presence of exaggerated and protracted inflammation.
Apodization of spurs in radar receivers using multi-channel processing (2023)

The various technologies presented herein relate to identification and mitigation of spurious energies or signals (aka "spurs") in radar imaging. Spurious energy in received radar data can be a consequence of non-ideal component and circuit behavior. Such behavior can result from I/Q imbalance, nonlinear component behavior, additive interference (e.g. cross-talk, etc.), etc. The manifestation of the spurious energy in a radar image (e.g., a range-Doppler map) can be influenced by appropriate pulse-to-pulse phase modulation. Comparing multiple images which have been processed using the same data but of different signal paths and modulations enables identification of undesired spurs, with subsequent cropping or apodization of the undesired spurs from a radar image. Spurs can be identified by comparison with a threshold energy. Removal of an undesired spur enables enhanced identification of true targets in a radar image.
Septicaemia (1975)

Septicaemia still presents a major diagnostic and therapeutic challenge to the clinician. Most cases are hospital-acquiredand the reasons for their increasing prevalence are discussed, with reference to predisposing factors and opportunistic infections. The pathology and bacteriology of proven cases (positive blood cultures) in 1974 in a modern children's and maternity hospital complex are presented. Gram-positive and Gram-negative varieties are compared and the molecular biology and mechansims of endo- and exotoxaemia described. Successful therapy demands correct choice of antibiotic and the development of shock requires skilled supportive measures. For the former a rational scheme is outlined and a plea is made for collection of data for this purpose. Polypharmacy is deprecated and either an aminoglycoside or a cephalosporin forms the mainstay of therapy. The emergence of Bacteroids sp. in cases of abdominal and puerperal sepsis necessitates addition of a lincomycin or metronidazole. Superinfection with systemic candidiasis requires 5-fluorocytosine.
Cloning of MMP‐26 (2000)

A cDNA encoding a novel human matrix metalloproteinase (MMP), named MMP-26, was cloned from fetal cDNA. The deduced 261-amino-acid sequence is homologous to macrophage metalloelastase (51.8% identity). It includes only the minimal characteristic features of the MMP family: a signal peptide, a prodomain and a catalytic domain. As with MMP-7, this new MMP does not comprise the hemopexin domain, which is believed to be involved in substrate recognition. A study of MMP-26 mRNA steady states levels reveals, among the tissue examined, a specific expression in placenta. MMP-26 mRNA could also be detected in several human cell lines such as HEK 293 kidney cells and HFB1 lymphoma cells. Recombinant MMP-26 was produced in mammalian cells and used to demonstrate a proteolytic activity of the enzyme on gelatin and beta-casein.
Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections (2018)

<i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> are two of the most common causes of bacterial keratitis and corresponding corneal blindness. Accordingly, such infections are predominantly treated with broad-spectrum fluoroquinolones, such as moxifloxacin. Yet, the rising fluoroquinolone resistance has necessitated the development of alternative therapeutic options. Herein, we describe the development of a polymyxin B-trimethoprim (PT) ophthalmic formulation containing the antibiotic rifampin, which exhibits synergistic antimicrobial activity toward a panel of contemporary ocular clinical <i>S. aureus</i> and <i>P. aeruginosa</i> isolates, low spontaneous resistance frequency, and <i>in vitro</i> bactericidal kinetics and antibiofilm activities equaling or exceeding the antimicrobial properties of moxifloxacin. The PT plus rifampin combination also demonstrated increased efficacy in comparison to those of either commercial PT or moxifloxacin in a murine keratitis model of infection, resulting in bacterial clearance of 70% in the animals treated. These results suggest that the combination of PT and rifampin may represent a novel antimicrobial agent in the treatment of bacterial keratitis.
OSEKtime: A Dependable Real-Time Fault-Tolerant Operating System and Communication Layer as an Enabling Technology for By-Wire Applications (2000)

<div class="htmlview paragraph">The new generation of drive-by-wire systems currently under development has demanding requirements on the electronic architecture. Functions such as brake-by-wire or steer-by-wire require continued operation even in the presence of component failures. The electronic architecture must therefore provide fault-tolerance and real-time response. This in turn requires the operating system and the communication layer to be predictable, dependable and composable. It is well known that this properties are best supported by a time-triggered approach. A consortium consisting of German and French car manufacturers and suppliers, which aims at becoming a working group within the OSEK/VDX initiative, the OSEKtime consortium, is currently defining a specification for a time-triggered operating system and a fault-tolerant communication layer.<span class="xref"><sup>1</sup></span> The operating system and the communication layer are based on applicable interfaces of the OSEK/VDX standard. This paper describes the basic concepts of these two service layers and the electronic architecture.</div>
Tunable filter and modulator with controlled bandwidth and wide dynamic range based on planar thin films structure (2019)

Tunable narrowband spectral filters with high throughput and wide dynamic range are in high demand for many applications, however, a cost is usually associated with the filter narrowing either in the dynamic range, in the throughput or the manufacturability. Here it is shown for the first time that using the coupling between waveguide and lossy modes (LMs) in lossy ultrathin films through thin film coupling layer it is possible to obtain a reflection peak with controllable width (sub-Angstroms till tens of nm) and tunability over wide spectral range (>500nm in the visible and near infrared). The excitation of broadband LM is enabled using an ultrathin absorptive layer with high imaginary to real part ratio of the dielectric constant (i.e 6nm of Cr). The wider dynamic range and higher contrast are observed more with TE polarization than TM. The tuning is achieved by incidence angle scan of few degrees or by modulating the waveguide layer from the visible till the near infrared and in principle it can be designed to operate in any spectral range. Such a thin waveguide layer can allow tuning at ultrahigh speed using conventional electrooptic, magnetooptic, piezoelectric or thermooptic materials using relatively low external fields. The tuning sensitivity and range depend strongly on the waveguide layer thickness and the refractive index mismatch between the waveguide and the coupling layer. Under small index mismatch new peaks are seen via Rabi type splitting with gaps as high as 700nm or more, thus exhibiting ultrahigh tuning with negative sensitivity.
Treatment Response in Kawasaki Disease Is Associated with Sialylation Levels of Endogenous but Not Therapeutic Intravenous Immunoglobulin G (2013)

Our data indicate sialylation levels of therapeutic IVIG are unrelated to treatment response in KD. Rather, lower sialylation of endogenous IgG and lower blood levels of ST6GALI mRNA and ST6Gal-I enzyme predict therapy resistance. These differences were stable over time, suggesting a genetic basis. Because IVIG-resistance increases risk of coronary artery aneurysms, our findings have important implications for the identification and treatment of such individuals.
Towards Exhaustive and Automated High-Throughput Screening for Crystalline Polymorphs (2014)

Methods capable of exhaustively screening for crystal polymorphism remain an elusive goal in solid-state chemistry. Particularly promising among the new generation of approaches is polymer-induced heteronucleation (PIHn), a tool utilizing hundreds of unique polymers for granting kinetic access to polymorphs. Here PIHn is redeployed in a high density format in which 288 distinct polymers, each acting as a heteronucleant, are arrayed on one substrate. This format allows determining the outcome of thousands of crystallizations in an automated fashion with only a few milligrams of sample. This technology enables the study of a broader range of targets, including preclinical candidates, facilitating determination of polymorphism propensity much earlier in the drug development process. Here the efficacy of this approach is demonstrated using four pharmaceutically relevant compounds: acetaminophen, tolfenamic acid, ROY, and curcumin.
Experimental demonstration of perturbative anticrossing mitigation using nonuniform driver Hamiltonians (2017)

Perturbative anticrossings have long been identified as a potential computational bottleneck for quantum annealing. This bottleneck can appear, for example, when a uniform transverse driver Hamiltonian is applied to each qubit. Previous theoretical research sought to alleviate such anticrossings by adjusting the transverse driver Hamiltonians on individual qubits according to a perturbative approximation. Here we apply this principle to a physical implementation of quantum annealing in a D-Wave 2000Q system. We use samples from the quantum annealing hardware and per-qubit anneal offsets to produce nonuniform driver Hamiltonians. On small instances with severe perturbative anticrossings, our algorithm yields an increase in minimum eigengaps, ground-state success probabilities, and escape rates from metastable valleys. We also demonstrate that the same approach can mitigate biased sampling of degenerate ground states.
Design Techniques for Bandpass Filters Using Edge-Coupled Microstrip Lines on Fused Silica (2005)

This paper presents a simple computer model for edge-coupled microstrip line. The model includes the effects of unequal odd/even phase velocities, end-effect capacitance, and loss. The bandpass filter design procedure described herein uses the model to select final element values. Agreement for filters constructed on fused silica in comparison with their computer model is very good. Data are provided for a filter operating over 11.5 to 12.4 GHz. These results are obtained on the first mask and with no bench adjustment.