gebhart/patrepeval huggingface dataset:
Pro-inflammatory and Anti-inflammatory Cytokines in Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy (2009)

To determine the intra-vitreous levels of two pro-inflammatory cytokines [interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1)] and the anti-inflammatory cytokine interleukin-10 (IL-10) in patients with proliferative diabetic retinopathy (PDR). In addition, the relationship between the level of cytokines and PDR activity had also been evaluated. The study included 23 diabetic patients with PDR (13 diabetic patients with inactive PDR and 10 diabetic patients with active PDR). Sixteen age-matched non-diabetic patients with macular hole served as a control group. IL-8, MCP-1 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). The vitreal levels of both IL-8 and MCP-1 were significantly higher in diabetic patients with PDR in comparison with the control group. In addition, the vitreous concentrations of IL-8 and MCP-1 were higher in patients with active PDR than in those patients with inactive PDR However, no significant difference was detected in the vitreal levels of IL-10 between diabetic patients and the control group. The pro-inflammatory cytokines IL-8 and MCP-1 are increased in the vitreous fluid of PDR patients without an increase in the anti-inflammatory cytokine IL-10. In addition, both intra-vitreous IL-8 and MCP-1 levels are asssociated with PDR activity, thus suggesting that these cytokines may be pathogenically related to PDR
Partial Discharge Detection in High Voltage Equipment (1990)

Electrical discharges that do not completely bridge the electrodes are called partial discharges. Although small, these discharges have been known for more than fifty years to cause progressive deterioration. Since 1945 the use of new high voltage dielectrics has required the use of sophisticated detection techniques. Discharge detection has grown into an indispensible tool for the evaluation of modern insulation. The subject has received little attention in books on high voltage techniques although a good deal is scattered in various papers and reports. The object of this book is to collect this knowledge and present it as a coherent study. Topics covered include the behaviour detection and measurement of discharges, the choice of detection method and procedure, the location of discharges and discharge detection in practice.
Three phase current reconstruction method using predictive current in three shunt sensing PWM inverter (2016)

When the vector control is performed using PWM three phase inverter in AC motor drive system, three phase current are obtained by measuring voltage between shunt resistors. The PWM inverter obtaining three phase current by shunt resistor is comparatively cheaper than the method that measures three phase current by Current Sensor. And it reduces the size of AC motor drive system. However, the method sensing the phase current using shunt resistor cannot perform the vector control in high motor speed since there is the area that cannot measure three phase current. In this paper, the boundary where phase currents cannot be obtained is defined and the method reconstructing the phase current is proposed by predicting phase current through load modeling in the area which phase current measurement is impossible. The proposed method can restore phase current up to maximum output voltage of SVPWM inverter in linear area and validity of proposed method is proved through simulation.
Collagen XVI Harbors an Integrin α1β1 Recognition Site in Its C-terminal Domains (2006)

Collagen XVI is integrated tissue-dependently into distinct fibrillar aggregates, such as D-banded cartilage fibrils and fibrillin-1-containing microfibrils. In skin, the distribution of collagen XVI overlaps that of the collagen-binding integrins alpha1 beta1 and alpha2 beta1. Basal layer keratinocytes express integrin alpha2 beta1, whereas integrin alpha1 beta1 occurs in smooth muscle cells surrounding blood vessels, in hair follicles, and on adipocytes. Cells bearing the integrins alpha1 beta1 and alpha2 beta1 attach and spread on recombinant collagen XVI. Furthermore, collagen XVI induces the recruitment of these integrins into focal adhesion plaques, a principal step in integrin signaling. Of potential physiological relevance, these integrin-collagen XVI interactions may connect cells with specialized fibrils, thus contributing to the organization of fibrillar and cellular components within connective tissues. In cell-free binding assays, collagen XVI is more avidly bound by alpha1 beta1 integrin than by alpha2 beta1 integrin. Both integrins interact with collagen XVI via the A domain of their alpha subunits. A tryptic collagen XVI fragment comprising the collagenous domains 1-3 is recognized by alpha1 beta1 integrin. Electron microscopy of complexes of alpha1 beta1 integrin with this tryptic collagen XVI fragment or with full-length collagen XVI revealed a unique alpha1 beta1 integrin-binding site within collagen XVI located close to its C-terminal end.
Hypoglycemic and antioxidant effects of Hibiscus rosa-sinensis L. leaves extract on liver and kidney damage in streptozotocin induced diabetic rats (2017)

Hibiscus is commonly used traditionally for the treatment of some diseases such as hypertension and as antidiabetic herbal medicine. The objective of the present study is to investigate the effect of the oral administration of aqueous methanolic extract of Hibiscus rosa-sinensis leaves (400 mg/Kg) on streptozotocin (STZ) induced diabetic rats and alteration in liver and kidney functions. The treatment of diabetic rats with hibiscus leaves extract reduced levels of plasma glucose, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid and creatinine and hepatic malondialdehyde that was elevated in diabetic rats. Moreover, the Hibiscus leaves extract mitigates the decrease in hepatic superoxide dismutase and plasma protein levels due to STZ injection. The treatment of rats with STZ only results in some pathological effects in liver and kidneys as degeneration in most of hepatocyte and glomeruli. The extract of H. rosa-sinensis leaves reduced the pathological changes. The treatment of diabetic rats with Hibiscus extract was shown to have hepatic and renal protective effects in diabetic rats induced experimentally. Here, two compounds, that is, orientin (Luteolin-8-C-glucoside) and verbascoside (phenylpropanoids glycoside) were isolated from H. rosa-sinsensis. The two compounds were identified by spectral analysis (UV, 1H and 13C-NMR). These results clearly indicate that aqueous leaves extract of H. rosa-sinensis possess antidiabetic and hypolipidemic effects in diabetic rats which may be due to antioxidant properties of the hibiscus extract.   Key words: Hibiscus rosa-sinensis, hypoglycemic, antioxidant, orientin, verbascoside.
Practical considerations for 3-D image reconstruction using spherically symmetric volume elements (1996)

Spherically symmetric volume elements with smooth tapering of the values near their boundaries are alternatives to the more conventional voxels for the construction of volume images in the computer. Their use, instead of voxels, introduces additional parameters which enable the user to control the shape of the volume element (blob) and consequently to control the characteristics of the images produced by iterative methods for reconstruction from projection data. For images composed of blobs, efficient algorithms have been designed for the projection and discrete back-projection operations, which are the crucial parts of iterative reconstruction methods. The authors have investigated the relationship between the values of the blob parameters and the properties of images represented by the blobs. Experiments show that using blobs in iterative reconstruction methods leads to substantial improvement in the reconstruction performance, based on visual quality and on quantitative measures, in comparison with the voxel case. The images reconstructed using appropriately chosen blobs are characterized by less image noise for both noiseless data and noisy data, without loss of image resolution.
The Organizing Potential of Sphingolipids in Intracellular Membrane Transport (2001)

Eukaryotes are characterized by endomembranes that are connected by vesicular transport along secretory and endocytic pathways. The compositional differences between the various cellular membranes are maintained by sorting events, and it has long been believed that sorting is based solely on protein-protein interactions. However, the central sorting station along the secretory pathway is the Golgi apparatus, and this is the site of synthesis of the sphingolipids. Sphingolipids are essential for eukaryotic life, and this review ascribes the sorting power of the Golgi to its capability to act as a distillation apparatus for sphingolipids and cholesterol. As Golgi cisternae mature, ongoing sphingolipid synthesis attracts endoplasmic reticulum-derived cholesterol and drives a fluid-fluid lipid phase separation that segregates sphingolipids and sterols from unsaturated glycerolipids into lateral domains. While sphingolipid domains move forward, unsaturated glycerolipids are retrieved by recycling vesicles budding from the sphingolipid-poor environment. We hypothesize that by this mechanism, the composition of the sphingolipid domains, and the surrounding membrane changes along the cis-trans axis. At the same time the membrane thickens. These features are recognized by a number of membrane proteins that as a consequence of partitioning between domain and environment follow the domains but can enter recycling vesicles at any stage of the pathway. The interplay between protein- and lipid-mediated sorting is discussed.
The Montgomery inverse and its applications (1995)

The Montgomery inverse of b module a is b/sup -1/2/sup n/ mod a, where n is the number of bits in a. The right-shifting binary algorithm for modular inversion is shown naturally to compute the new inverse in fewer operations than the ordinary modular inverse. The new inverse facilitates recent work by Koc on modular exponentiation and has other applications in cryptography.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Efficiently Outsourcing Multiparty Computation Under Multiple Keys (2013)

Secure multiparty computation enables a set of users to evaluate certain functionalities on their respective inputs while keeping these inputs encrypted throughout the computation. In many applications, however, outsourcing these computations to an untrusted server is desirable, so that the server can perform the computation on behalf of the users. Unfortunately, existing solutions are either inefficient, rely heavily on user interaction, or require the inputs to be encrypted under the same public key - drawbacks making the employment in practice very limited. We propose a novel technique based on additively homomorphic encryption that avoids all these drawbacks. This method is efficient, requires no user interaction whatsoever (except for data upload and download), and allows evaluating any dynamically chosen function on inputs encrypted under different public keys. Our solution assumes the existence of two non-colluding but untrusted servers that jointly perform the computation by means of a cryptographic protocol. This protocol is proven to be secure in the semi-honest model. By developing application-tailored variants of our approach, we demonstrate its versatility and apply it in two real-world scenarios from different domains, privacy-preserving face recognition and private smart metering. We also give a proof-of-concept implementation to highlight its feasibility.
Benzyl 2-Cyano-3,3-Dimethyl-1-pyrrolidinecarboxylate, a Versatile Intermediate for the Synthesis of 3,3-Dimethylproline Derivatives (2008)

The synthesis of racemic nitrile (+/-)-9 was accomplished in four steps and 58% overall yield from the known pyrrolidinone 5. Nitrile (+/-)-9 was resolved via preparative chiral HPLC to afford optically pure nitriles (+)-9 and (-)-9, from which 3,3-dimethylprolines (+)-1 and (-)-1 and 3,3-dimethylprolinamides (+)-2 and (-)-2 could be accessed in nearly quantitative yield, without loss of optical purity. The absolute configurations of the resolved prolines and prolinamides were determined by correlation with an intermediate of known absolute stereochemistry.
In vivo photoacoustic oxygen saturation imaging without the need for fluence estimation (2014)

Due to the difference between the absorption spectra of reduced and oxygenated haemoglobin, spectroscopic photoacoustic imaging can be used to determine, in vivo and non-invasively, the local blood oxygen saturation. Conventional methods achieve this by computing the absolute concentrations of reduced and oxygenated haemoglobin, which require models for, or computations of, the local fluence at depth. However, such estimates are potentially inaccurate or expensive to compute. In this work, fluence estimation is circumvented by modelling the absorption spectra. Over local wavelength ranges the absorption spectra of reduced and oxygenated haemoglobin can accurately be represented by linear functions, and extrapolating the best-fit straight lines to zero absorption yields a fluenceindependent quantity that is readily converted to a blood oxygen saturation level. Using a clinical photoacoustic scanner, spectroscopic images were obtained from the second author's inner elbow in the wavelength range between 761 and 793 nm. Regions of interest containing signal from either an artery or a vein were analysed with the new method, and yielded oxygen saturation values of 97 % and 70 %, respectively, which are in agreement with literature. Thus, these preliminary results suggest that the presented method can effectively determine local oxygen saturation in vivo and at depth.
MOSIQS: Persistent Memory Object Storage With Metadata Indexing and Querying for Scientific Computing (2021)

Scientific applications often require high-bandwidth shared storage to perform joint simulations and collaborative data analytics. Shared memory pools provide a chance to satisfy such needs. Recently, a high-speed network such as Gen-Z utilizing persistent memory (PM) offers an opportunity to create a shared memory pool connected to compute nodes. However, there are several challenges to use scientific applications on the shared memory pool directly such as scalability, failure-atomicity, and lack of scientific metadata-based search and query. In this paper, we propose MOSIQS, a persistent memory object storage framework with metadata indexing and querying for scientific computing. We design MOSIQS based on the key idea that memory objects on PM pool can live beyond the application lifetime and can become the sharing currency for applications and scientists. MOSIQS provides an aggregate memory pool atop an array of persistent memory devices to store and access memory objects to accelerate scientific computing. MOSIQS uses a lightweight persistent memory key-value store to manage the metadata of memory objects, which enables memory object sharing. To facilitate metadata search and query over millions of memory objects resident on memory pool, we introduce Group Split and Merge (GSM), a novel persistent index data structure designed primarily for scientific datasets. GSM splits and merges dynamically to minimize the query search space and maintains low query processing time while overcoming the index storage overhead. MOSIQS is implemented on top of PMDK. We evaluate the proposed approach on many-core server with an array of real PM devices. Experimental results show that MOSIQS gains a 100% write performance improvement and executes multi-attribute queries efficiently with 2.7× less index storage overhead offering significant potential to speed up scientific computing applications.
Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients (2011)

Circulating miR-210 levels were associated with trastuzumab sensitivity, tumor presence, and lymph node metastases. These results suggest that plasma miR-210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab.
DeAliaser (2013)

Alias analysis is a critical component in many compiler optimizations. A promising approach to reduce the complexity of alias analysis is to use speculation. The approach consists of performing optimizations assuming the alias relationships that are true most of the time, and repairing the code when such relationships are found not to hold through runtime checks.
Aircraft air conditioning system health state estimation and prediction for predictive maintenance (2019)

The vast potential of system health monitoring and condition based maintenance on modern commercial aircraft is being realized through the innovative use of Airplane Condition Monitoring System (ACMS) data. However there are few methods addressing the issues of failure prognostics and predictive maintenance for commercial aircraft Air Conditioning System (ACS). This study developed a Bayesian failure prognostics approach using ACMS data for predictive maintenance of ACS. First, a health index characterizing the ACS health state is inferred from a multiple sensor signals using a data driven method. Then a dynamic linear model is proposed to describe the degradation process for failure prognostics. Bayesian inference formulas are carried out for degradation estimation and prediction. The developed approach is applied on a passenger aircraft fleet with ACMS data recorded for one year. The analysis of the case study shows that the developed method can produce satisfactory prognostics results, where all the ACS failure precursors are identified in advance, and the relative errors for the failure time prediction made when just entering the degradation warning stage are less than 8%. This would allow operators to proactively plan future maintenance.
Isolation of cDNA Encoding Guinea Pig Neutrophil Cationic Antibacterial Polypeptide of 11 kDa (CAP11) and Evaluation of CAP11 mRNA Expression during Neutrophil Maturation (1997)

Neutrophils contain various antibacterial polypeptides and proteins in the granules that contribute to the killing of microorganisms. Recently, we have purified a cationic antibacterial polypeptide of 11 kDa (CAP11) from guinea pig neutrophil granules. CAP11 is a homodimer of G1LRKKFRKTRKRIQKLGRKIGKTGRKVWKAWREYGQIPYPCRI43 joined with one disulfide bond. In this study, to understand the regulation of CAP11 expression, we isolated and analyzed cDNA encoding CAP11. Furthermore, we investigated the expression of CAP11 mRNA during neutrophil maturation and localization of CAP11 among neutrophil granule subsets. Sequence analysis of CAP11 cDNA isolated from guinea pig bone marrow cells using rapid amplification of cDNA ends technique indicated that CAP11 is synthesized as a precursor comprising 178 amino acid residues, which is composed of a signal peptide (N-terminal 29 residues), a propeptide (106 residues), and a C-terminal mature peptide (43 residues). Interestingly, the predicted CAP11 precursor displayed the characteristic features of cathelicidins, a novel protein family of antibacterial polypeptides with a conserved cathelin-like pro-region and a variable C-terminal antibacterial domain. Northern blot and Western blot analyses using neutrophils, macrophages, eosinophils, mononuclear cells, and bone marrow cells revealed that only neutrophils and bone marrow cells expressed CAP11 mRNA and contained CAP11, suggesting that expression of CAP11 is neutrophil lineage-specific. Furthermore, Northern blot analysis using bone marrow cells separated according to their maturation stages showed that CAP11 mRNA was predominantly expressed in the cells at later stages of neutrophil maturation. Consistent with this, in situ hybridization using CAP11-specific cRNA probe demonstrated that CAP11 mRNA was primarily expressed at metamyelocyte stage. In addition, extracellular release assay revealed that CAP11 was readily released from neutrophils accompanied with gelatinase by low concentrations of N-formyl-Met-Leu-Phe without release of specific and azurophil granule components, and CAP11 was found to be exclusively present in the fraction containing gelatinase granules, prepared by Percoll density gradient centrifugation. Together these observations indicate that CAP11 is a member of cathelicidin family and its mRNA is preferentially expressed at the later stage of neutrophil maturation (i.e. metamyelocyte stage). Furthermore, CAP11 may be stored in the granule subset, possibly the gelatinase granule.
Carbon nanostructures production by gas-phase plasma processes at atmospheric pressure (2007)

Carbon nanostructures have received much attention for a wide range of applications.This paper reviews the historical role of plasmas in the gas-phase synthesis of carbon nanostructures and the present plasma technologies for industrial production purposes.It enumerates the advantages and disadvantages with respect to concurrent technologies commonly employed nowadays.Finally, some carbon nanostructures produced in our laboratory will serve as examples of the plasma processes potential.
An error propagation algorithm for continuous systems with multiple operational modes (1977)

An algorithm appropriate to the analysis of errors expected of a system with multiple modes of operation is developed. Random mode-to-mode transitions are considered in terms of a continuous-time Markov process. An example is presented to demonstrate the application of the technique to the analysis of an aircraft radio navigation system with the capability to automatically switch from one station to another.