gebhart/patrepeval huggingface dataset:
Study on resistance of transgenic Bt+CPTI glandless cotton to bollworm and wilt diseases (2004)

The resistance of two transgenic Bt+CPTI glandless cotton varieties ( C020 and C022 ) to bollworm and wilt diseases was studied. The results of indoor identification indicated that the resistance of two transgenic glandless cotton varieties to bollworm was low, and significantly lower than that of transgenic gossypol cotton variety SGKz9, but slightly higher than that of conventional gossypol cotton variety Simian 3. The results of field cage identification revealed that both C020 and C022 performed high-resistance to bollworm, being similar to SGKz9and significantly better than Simian 3. The resistance of C020 and C022 to wilt diseases was as follows: C020 was highly resistant to Fusarium wilt, while sensitive to Verticillium wilt; C022 was sensitive to Verticillium wilt, while tolerant to Fusarium wilt.
Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases (2006)

At both the evaluated cut-off values serum MCA sensitivity is higher than that of CEA, TPA or CA15.3 but its specificity is similar to or lower than that of TPA. Overall, CEA-TPA-CA15.3 panel is more accurate than MCA-CA15.3 association and can "early" detect a few relapsed patients with limited metastatic disease and more favourable prognosis. These findings further support the need for prospective randomised clinical trial to assess whether an intensive post-operative follow-up with an appropriate use of serum tumour markers can significantly improve clinical outcome of early detected relapsing patients.
Differential expression of inhibitory receptor NKG2A distinguishes disease‐specific exhausted CD8<sup>+</sup> T cells (2022)

Exhausted CD8<sup>+</sup> T (Tex) cells are caused by persistent antigenic stimulation during chronic viral infection or tumorigenesis. Tex cells upregulate and sustain the expressions of multiple immune inhibitory receptors (IRs). Blocking IRs of Tex cells, exemplified by PD-1, can partially restore their effector functions and thus lead to viral suppression or tumor remission. Tex cells derived from chronic viral infections share the expression spectrum of IRs with Tex cells derived from tumors; however, whether any IRs are selectively expressed by tumor-derived Tex cells or virus-derived Tex cells remains to be learnt. In the study, we found that Tex cells upregulate IR natural killer cell lectin-like receptor isoform A (NKG2A) specifically in the context of tumor but not chronic viral infection. Moreover, the NKG2A expression is attributed to tumor antigen recognition and thus bias expressed by tumor-specific Tex cells in the tumor microenvironment instead of their counterparts in the periphery. Such dichotomous NKG2A expression further dictates the differential responsiveness of Tex cells to NKG2A immune checkpoint blockade. Therefore, our study highlighted NKG2A as a disease-dependent IR and provided novel insights into the distinct regulatory mechanisms underlying T cell exhaustion between tumor and chronic viral infection.
Effects of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on platelet aggregation and thrombosis in experimental animals. (1992)

Antiplatelet and antithrombotic effects of KC-764 (2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine, CAS 94457-09-7) were studied. KC-764 inhibited arachidonic acid (AA)- and collagen-induced platelet aggregation with IC50s of 1.0 x 10(-8)-2.8 x 10(-7) mol/l for humans, rabbits, guinea pigs and dogs, and IC50s of 3.9 x 10(-6)-3.7 x 10(-5) mol/l for mice and rats in vitro. KC-764 inhibited AA- and collagen-induced aggregation with ID50s of 0.04-0.09 mg/kg p.o. in rabbits and dogs, and ID50 of 13.0 mg/kg p.o. in rats. These antiaggregatory activities of KC-764 were stronger than those of acetyl-salicylic acid (ASA), indometacin, cilostazol and ticlopidine. KC-764 inhibited the production of thromboxane B2 (TXB2) in rabbit platelet microsomes, washed platelets and reconstituted platelet rich plasma (RPRP) with IC50s of 2.9 x 10(-6) mol/l, 2.8 x 10(-7) mol/l and 4.3 x 10(-8) mol/l, respectively. The in vitro inhibitory activity of KC-764 on AA-induced platelet aggregation was more potent when RPRP was used rather than washed platelet suspension containing 30% rabbit plasma. ASA did not show such an augmentation. KC-764 prevented collagen- and AA-induced thrombosis at more than 1 mg/kg p.o. and more than 0.1 mg/kg i.v. in mice and rabbits. KC-764 showed the wider margin of dose between antiplatelet action and prolongation of bleeding time in rabbits than ASA and indometacin. These results indicated that KC-764 was a potent antithrombotic drug to prevent TXB2 production and less possible to induce untoward actions as compared with ASA or indometacin.
Efficient Limited Feedback Schemes for Network MIMO Systems (2011)

In this paper, a feedback channel selection scheme and a bit allocation scheme are proposed for a network MIMO system with limited feedback. The feedback channel selection is performed by comparing the gain of each channel vector with a certain threshold. In particular, we derive an optimal threshold that maximizes a utility function, which is defined in terms of the expected rate of each user. In addition, we also develop an unequal feedback bit allocation scheme over the selected set of channels to further improve the system performance. It is shown that the joint feedback channel selection and bit allocation can provide significant gain in the average sum rate for a network MIMO system with limited feedback.
Empty container repositioning in liner shipping (2009)

The efficient and effective management of empty containers is an important problem in the shipping industry. Not only does it have an economic effect, but it also has an environmental and sustainability impact, since the reduction of empty container movements will reduce fuel consumption and reduce congestion and emissions. The purposes of this paper are: to identify critical factors that affect empty container movements; to quantify the scale of empty container repositioning in major shipping routes; and to evaluate and contrast different strategies that shipping lines, and container operators, could adopt to reduce their empty container repositioning costs. The critical factors that affect empty container repositioning are identified through a review of the literature and observations of industrial practice. Taking three major routes (Trans-Pacific, Trans-Atlantic, Europe–Asia) as examples, with the assumption that trade demands could be balanced among the whole network regardless the identities of individual shipping lines, the most optimistic estimation of empty container movements can be calculated. This quantifies the scale of the empty repositioning problem. Depending on whether shipping lines are coordinating the container flows over different routes and whether they are willing to share container fleets, four strategies for empty container repositioning are presented. Mathematical programming is then applied to evaluate and contrast the performance of these strategies in three major routes.
Cache conscious Walsh-Hadamard transform (2002)

The Walsh-Hadamard Transform (WHT) is an important algorithm in signal processing because of its simplicity. However, in computing large size WHT, non-unit stride access results in poor cache performance leading to severe degradation in performance. This poor cache performance is also a critical problem in achieving high performance in other large size signal transforms. We develop a cache friendly technique that improves the performance of large size WHT. In our approach, data reorganization is performed between computation stages to reduce cache pollution. Furthermore, we develop an efficient search algorithm to determine the optimal factorization tree based upon problem size and stride access in the decomposition. Experimental results show that our approach achieves up to 180% performance improvement over the state of the art package on Alpha 21264 and MIPS R10000. In addition, the proposed optimization is applicable to other signal transforms and is portable across various platforms.
교량, 터널, 전기, 신호분야 BIM 라이브러리 프로토타입 개발 (2017)

BIM(Building Information Modeling)기반 3차원 설계 시 적절한 BIM 라이브러리의 구축 및 활용은 설계 효율성을 높여주고, 안정적인 설계품질을 확보하는데 도움을 줄 수 있다. 건축분야와 달리 토목분야, 특히 철도시설분야에서는 라이브러리의 구축 및 표준화가 미진하다. 본 연구에서는 교량, 터널, 전기, 신호 등의 철도시설분야에 대해 3차원 BIM 라이브러리를 구축하고 표준화하고자 한다. 이를 위해 기존 철도시설물 분류체계 및 철도 관련도면을 수집 및 분석하여 라이브러리로 구현 하였을 때 효과적인 대상을 선정한다. 도출된 대상을 라이브러리화 하기 적합한 레벨로 분개하고 적합한 소프트웨어를 검토한다. 소프트웨어별로 라이브러리 프로토타입을 구축하고 속성 항목과 명세서를 작성한다. 향후 실무자 검증을 통해 라이브러리의 유용성 및 보완 방향을 도출할 예정이다.
Regulation of the NMDA Receptor Complex and Trafficking by Activity-Dependent Phosphorylation of the NR2B Subunit PDZ Ligand (2004)

Interactions between NMDA receptors (NMDARs) and the PDZ [postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] domains of PSD-95/SAP90 (synapse-associated protein with a molecular weight of 90 kDa) family proteins play important roles in the synaptic targeting and signaling of NMDARs. However, little is known about the mechanisms that regulate these PDZ domain-mediated interactions. Here we show that casein kinase II (CK2) phosphorylates the serine residue (Ser1480) within the C-terminal PDZ ligand (IESDV) of the NR2B subunit of NMDAR in vitro and in vivo. Phosphorylation of Ser1480 disrupts the interaction of NR2B with the PDZ domains of PSD-95 and SAP102 and decreases surface NR2B expression in neurons. Interestingly, activity of the NMDAR and Ca2+/calmodulin-dependent protein kinase II regulates CK2 phosphorylation of Ser1480. Furthermore, CK2 colocalizes with NR1 and PSD-95 at synaptic sites. These results indicate that activity-dependent CK2 phosphorylation of the NR2B PDZ ligand regulates the interaction of NMDAR with PSD-95/SAP90 family proteins as well as surface NMDAR expression and may be a critical mechanism for modulating excitatory synaptic function and plasticity.
Watermites (Acari, Prostigmata) from Iran .5. Hydrovolzia persica, nov. spec. (1980)

Wassermilben (acari, prostigmata) aus dem iran - 5. Mitteilung. - The position of Hydrovolzia within the system of Hydracarina is being discussed, also the geographical distribution. The Asian-species аге not identical with the specimens found in Iran. The diagnosis of Hydrovolzia persica nov. spec. comprises text, measure data and drawings. The given SEM-photos аге опlу supplementary, they give valuable views of the fine structures.
Duet: Helping Data Analysis Novices Conduct Pairwise Comparisons by Minimal Specification (2018)

Data analysis novices often encounter barriers in executing low-level operations for pairwise comparisons. They may also run into barriers in interpreting the artifacts (e.g., visualizations) created as a result of the operations. We developed Duet, a visual analysis system designed to help data analysis novices conduct pairwise comparisons by addressing execution and interpretation barriers. To reduce the barriers in executing low-level operations during pairwise comparison, Duet employs minimal specification: when one object group (i.e. a group of records in a data table) is specified, Duet recommends object groups that are similar to or different from the specified one; when two object groups are specified, Duet recommends similar and different attributes between them. To lower the barriers in interpreting its recommendations, Duet explains the recommended groups and attributes using both visualizations and textual descriptions. We conducted a qualitative evaluation with eight participants to understand the effectiveness of Duet. The results suggest that minimal specification is easy to use and Duet's explanations are helpful for interpreting the recommendations despite some usability issues.
A Novel Series of Piperidin-4-yl-1,3-Dihydroindol-2-ones as Agonist and Antagonist Ligands at the Nociceptin Receptor (2004)

A series of N-(4-piperidinyl)-2-indolinones were discovered as a new structural class of nociceptin receptor (NOP) ligands. Unlike other previously reported classes of NOP receptor ligands, modifications of the piperidine N substituents afforded both potent agonists and antagonists, with modest selectivities over other opioid receptors. The SAR revealed in this new series will provide important insights for the development of pharmacophores for agonist and antagonist actions at the NOP receptor.
[Protective effect of lidocaine on injury alveolar Type II cells induced by LPS in adult rats]. (2006)

Lidocaine can directly inhibit the apoptosis and necrosis induced by LPS in cultured AT-II cells.
Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. (2004)

Alzheimer's disease is an age-related neurodegenerative disorder that is characterized by a progressive loss of memory and deterioration of higher cognitive functions. The brain of an individual with Alzheimer's disease exhibits extracellular plaques of aggregated beta-amyloid protein (Abeta), intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. Abeta accumulation may trigger or contribute to the process of neurodegeneration. However, the mechanisms whereby Abeta induces basal forebrain cholinergic cell loss and cognitive impairment remain obscure. Physiologically relevant concentrations of Abeta-related peptides have acute, negative effects on multiple aspects of acetylcholine (ACh) synthesis and release, without inducing toxicity. These data suggest a neuromodulatory influence of the peptides on central cholinergic functions. Long-term exposure to micromolar Abeta induces cholinergic cell toxicity, possibly via hyperphosphorylation of tau protein. Conversely, activation of selected cholinergic receptors has been shown to alter the processing of the amyloid precursor protein as well as phosphorylation of tau protein. A direct interaction between Abeta and nicotinic ACh receptors has also been demonstrated. This review addresses the role of Abeta-related peptides in regulating the function and survival of central cholinergic neurons and the relevance of these effects to cholinergic deficits in Alzheimer's disease. Understanding the functional interrelations between Abeta peptides, cholinergic neurons and tau phosphorylation will unravel the biologic events that precede neurodegeneration and may lead to the development of more effective pharmacotherapies for Alzheimer's disease.
On small terminal MIMO antenna correlation optimization adopting characteristic mode theory (2014)

This work proposes a MIMO antenna system for mobile terminals, based on a compact form factor and packaging implementation, with a very low magnitude of the complex correlation coefficient and an impressive isolation. An isolation better than 20 dB has been achieved using a folded monopole and a commonly adopted PIFA (planar inverted F antenna) on a platform with a very small form factor (100×50 mm). The proposed implementation is based in the application of the characteristic mode theory to obtain orthogonal radiation modes. The adopted topology enables uncorrelated antenna system at 750 MHz, while maintaining high total efficiency and adequate gain imbalance. In this present paper simulation model as well as prototype measurement results are presented, demonstrating the implementation feasibility of such antenna system in compact mobile device embodiment.
Trade-off analysis of QoS-aware configurable LTE downlink schedulers (2013)

The voice, video, and data traffic can be carried as IP packets over Long Term Evolution (LTE) networks which bring the cellular communication to the fourth generation (4G) era. LTE enables this digital convergence by offering higher capacity, including inherent IP support in its architecture, and supporting multi-user diversity scheduling. However, recent increases in Voice over IP (VoIP) and video traffic usage require the prioritization of the real-time traffic to meet its stringent QoS requirements. In this paper, the existing Round Robin and Best CQI schedulers are enhanced to enable the QoS support to the real-time traffic. For both schedulers, a configurable parameter, which determines the degree of priority level, is introduced so that the real-time traffic throughput can be administratively controlled without jeopardizing the overall network performance. Simulation results demonstrate the trade-off among the real-time traffic throughput, the overall system throughput and the overall system fairness for various scenarios.
Central serotonin receptors as targets for drug research (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCentral serotonin receptors as targets for drug researchRichard A. GlennonCite this: J. Med. Chem. 1987, 30, 1, 1–12Publication Date (Print):January 1, 1987Publication History Published online1 May 2002Published inissue 1 January 1987https://pubs.acs.org/doi/10.1021/jm00384a001https://doi.org/10.1021/jm00384a001research-articleACS PublicationsRequest reuse permissionsArticle Views611Altmetric-Citations266LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Effects of processing on antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati]. (2001)

After Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati were processed, their effects became weaker.
Support vector learning for ordinal regression (1999)

We investigate the problem of predicting variables of ordinal scale. This task is referred to as ordinal regression and is complementary to the standard machine learning tasks of classification and metric regression. In contrast to statistical models we present a distribution independent formulation of the problem together with uniform bounds of the risk functional. The approach presented is based on a mapping from objects to scalar utility values. Similar to support vector methods we derive a new learning algorithm for the task of ordinal regression based on large margin rank boundaries. We give experimental results for an information retrieval task: learning the order of documents with respect to an initial query. Experimental results indicate that the presented algorithm outperforms more naive approaches to ordinal regression such as support vector classification and support vector regression in the case of more than two ranks.
Regional specificities of monoclonal anti-human apolipoprotein B antibodies (1988)

The usefulness of monoclonal antibodies as probes of protein structure is directly related to knowledge of the structures and locations of the epitopes with which they interact. In this report we provide a detailed map of 13 epitopes on apoB-100 defined by our anti-apoB monoclonal antibodies based on current information on the amino acid sequence of apoB-100. To localize antibody specificities to smaller regions along the linear sequence of the apoB-100 molecule we used a) thrombin- and kallikrein-generated fragments of apoB-100; b) beta-galactosidase- apoB fusion proteins; c) heparin; and d) antibody versus antibody competition experiments. Most of the monoclonal antibodies elicited by immunization with LDL were directed towards epitopes within the first 1279 amino terminal (T4/K2 fragments) or last 1292 carboxyl terminal amino acid residues (T2/K4 fragments) of apoB-100. One epitope localized to the mid-portion of apoB-100 was elicited by immunization with VLDL (D7.2). Saturating amounts of heparin bound to LDL did not inhibit the binding of any of the monoclonal antibodies to their respective epitopes on apoB-100, indicating that none of the antibody determinants is situated close to any of the reported heparin binding sites on LDL apoB. We examined the expression of apoB epitopes on VLDL subfractions and LDL isolated from a normolipidemic donor. The apparent affinities with which the antibodies interacted with their respective epitopes on the VLDL subfractions and LDL uniformly increased as follows: LDL greater than VLDL3 greater than VLDL2 greater than VLDL1, suggesting that each of the major regions of apoB-100 is progressively more exposed as normal VLDL particles become smaller in size and epitopes are most exposed in LDL. Previous experiments utilizing hypertriglyceridemic VLDL subfractions yielded similar results, but the rank order of VLDL subfractions and LDL was not the same for all antibodies tested. Thus, differences in apoB epitope expression on VLDL particles of differing sizes is a general phenomenon, but the expression of apoB epitopes in hypertriglyceridemic VLDL appears to be more heterogeneous than is the case for VLDL from normolipidemic donors.(ABSTRACT TRUNCATED AT 400 WORDS)
Data-Cell-Variation-Tolerant Dual-Mode Sensing Scheme for Deep Submicrometer STT-RAM (2017)

In the spin-transfer-torque random access memory design, the sensing scheme has become a bottleneck from the viewpoints of performance and read energy, because the required read current and time are too large to satisfy a target read yield. When the target read yield is greater than the fundamental read-yield limit determined by bit-to-bit data-cell variation, the conventional data-cell-variation-tolerant (DCVT) sensing scheme cannot satisfy the target read yield without requiring impractically high performance and energy overhead. To resolve this problem, this paper proposes a DCVT dual-mode sensing scheme (DMSS) that operates mostly in normal mode when correct sensing is assured, and infrequently in exception mode when correct sensing is uncertain. Using the dual-mode strategy, the DMSS can achieve the target read yield, while significantly mitigating the performance and energy overhead. Monte-Carlo HSPICE simulation results, using industry-compatible 45-nm model parameters, show that the proposed DMSS achieves a read yield of 6.1 sigma with a 3.2× faster read time and 4.5× lower read energy than the destructive self-reference sensing scheme.