gebhart/patrepeval huggingface dataset:
MODELING THE DEPRESSIVE STATE IN RATS BY STEREOTAXIC INJECTION OF LIPOPOLYSACCHARIDE INTO THIRD VENTRICLE OF THE BRAIN (2021)

Introduction: More than 4.4% of the world's population suffers from depression, which dramatically reduces both quality and life expectancy. For an accurate understanding of the links of pathogenesis and the possibility of correcting the depressive state, translational studies are widely used - in laboratory rodents. According to the modern concept of the inflammatory genesis of depression, the creation of animal models with nonspecific inflammation on the territory of the central nervous system is an urgent task. Purpose of the work: creation of a model of the depressive state in rats by injecting LPS into the third ventricle of the brain. Materials and methods: the study was carried out on female rats Wistar 280-300g. (n = 10), divided into 3 groups: 1 - with the introduction of LPS (n = 4), 2 - sham-operated (n = 3) and 3 - intact (n = 3). LPS was administered at a dose of 50 μg / animal in at volume of 4 μl in 15 minutes, according to the following stereotaxic coordinates: AP-0.8 ML-1.5 DV-3.5. Depression was assessed using the sucrose test and the behavior of animals in the open field tests, the elevated plus maze, the dark-light chamber, and the Porsolt test. Confirmation of the correct administration was carried out using MRI scanning (7 days) and postmortem on histological sections. Results: Animals treated with LPS showed a decrease in sucrose consumption, both compared to the sham-operated group and compared to the intact group. In behavioral tests, there was a decrease in locomotor activity in rats with the influence of LPS, but the differences between the group of sham-operated rats were insignificant. The experimental group had a sharp increase in the time of immobility in the Parsolt test (89.6 s VS 32.6 s VS 22.2 s) for the first, second and third groups, respectively. In the behavior of animals in the burrow chamber and in the open field, the presence of a neurological deficit in the experimental group was noted, consisting in a violation of gait in three out of four rats, in other groups this effect was not observed. When analyzing MRI images, the trace from the needle is traced exactly to the third ventricle. On a histological section in rats with neurological deficit, a demyelination area is visible (Fig. 1). Conclusion: The introduction of LPS into the cavity of the third ventricle causes depressive-like behavior in rats, a decrease in locomotor activity, but causes manifestations of neurological deficit as a result of local demyelination of the nervous tissue. The work was carried out within the framework of the state assignment of the Federal State Budgetary Educational Institution of Higher Education named after V.I. N.I. Pirogov for 2021–2023, state no. registration research work AAAA-A18-118051590108-1
MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets (2015)

MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression by posttranscriptional and epigenetic mechanisms and thereby affect many cellular processes and disease states. Over 2,000 human mature miRNAs have been identified, and at least 60% of all human protein-coding genes are known to be regulated by miRNAs. MicroRNA biogenesis involves classical transcription regulation and processing by key ribonucleases, as well as other protein factors and epigenetic mechanisms. Diabetic nephropathy (DN), a severe microvascular complication frequently associated with diabetes mellitus, is a major cause of renal failure. Although several mechanisms of regulation of key renal genes implicated in DN pathogenesis have been identified, a greater understanding is needed to develop better treatment modalities. Recent studies show that miRNAs induced in renal cells in vivo and in vitro under diabetic conditions can promote the accumulation of extracellular matrix proteins related to fibrosis and glomerular dysfunction. In this review, we highlight the significance of the expression of miRNAs in various stages of DN and emerging approaches to exploit them as biomarkers for early detection or novel therapeutic targets to prevent progression of DN.
Isolation, Identification, and Characterization of New Color-Stable Anthocyanins Occurring in Some Red Wines (1997)

Four new anthocyanin pigments were found in red wines in trace amounts and are thought to be formed in wines during maturation. Their structures were established by FAB-MS and NMR. Two pigments were identified as the 3-glucoside (vitisin A) and the 3-acetylglucoside (acetylvitisin A) of malvidin containing a C3H2O2 grouping, linking carbon 4 and the 5-hydroxyl group of its molecule (vitisidin A). The other two anthocyanins were identified as the 3-glucoside (vitisin B) and the 3-acetylglucoside (acetylvitisin B) of malvidin containing a CHCH moiety linking carbon 4 and the 5-hydroxyl group of its molecule (vitisidin B or decarboxyvitisidin A). Unlike other anthocyanins these novel compounds were found to be wholly or partly resistant to bleaching by sulfur dioxide and express more color up to pH 7 than malvidin 3-glucoside. Detailed spectral measurements from 250 to 770 nm up to pH 7, including the use of CIELAB 76 measurements, indicate the formation of stable quinonoidal bases, confirming that there could be little formation of the colorless carbinol base forms. Keywords: Red wine; anthocyanins; vitisin A; vitisin B; vitisidin A; vitisidin B; NMR; FABMS
A Uniform Bimetallic Rhodium/Iron Nanoparticle Catalyst for the Hydrogenation of Olefins and Nitroarenes (2011)

Mix and more than match: Relative to the catalytic activity of pure Rh nanoparticles in a dendrimer cage, Rh/Fe bimetallic nanoparticles in dendrimers have improved catalytic activity towards the hydrogenation of olefins, and unlike Wilkinson catalyst could catalyze nitroarene hydrogenation (see scheme, G4=4th generation dendrimer).
Load balancing with availability checker and load reporters (LB-ACLRs) for improved performance in distributed systems (2014)

Distributed system has quite a lot of servers to attain increased availability of service and for fault tolerance. Balancing the load among these servers is an important task to achieve better performance. There are various hardware and software based load balancing solutions available. However there is always an overhead on Servers and the Load Balancer while communicating with each other and sharing their availability and the current load status information. Load balancer is always busy in listening to clients' request and redirecting them. It also needs to collect the servers' availability status frequently, to keep itself up-to-date. Servers are busy in not only providing service to clients but also sharing their current load information with load balancing algorithms. In this paper we have proposed and discussed the concept and system model for software based load balancer along with Availability-Checker and Load Reporters (LB-ACLRs) which reduces the overhead on server and the load balancer. We have also described the architectural components with their roles and responsibilities. We have presented a detailed analysis to show how our proposed Availability Checker significantly increases the performance of the system.
LONGITUDINAL FORCES IN WEBER'S ELECTRODYNAMICS (1995)

We analyze the existence of longitudinal forces with Weber's electrodynamics. We show that they exist. But they cannot explain the exploding wire phenomena due to their order of magnitude.
인간 상피성 자궁경부암 세포주 ( CUMC-6 ) 의 확립 및 특징화 (1996)

본 연구진은 31세된 한국여성의 자궁경부암 종양조직을 채취한 후 세포배양을 통하여 자궁경부의 편평상피암 세포주(CUMC-6)를 새로이 확립하여 시험관내 성장특성, 세포의 형태학적 특성, 세포의 초미세 구조, 생체내 종양형성 능력, 동위효소 발현, 염색체 특성, 호르몬 및 태반단백 분비, 종양표지물질분비, 스테로이드 호르몬 수용체 여부, 인체 백혈구 항원의 규명, 인유두종 바이러스(HPV) 감염,c-myc및 L-myc 발암유전자들의 변이, 및 p53 종양 억제 유전자의 변이여부를 검색하여 다음과 같은 결과를 얻었다. 1. 자궁경부암 세포주는 현재 61개월간 배양중에 있으며 지속적인 성장을 보였고 현재까지 연속적으로 300계대까지 수행되었다. 2. 배양중인 종양세포의 성장특성을 분석한 결과 population doubling time은 약 36시간이었으며 plating efficiency는 32%로 나타났다. 3. 배양세포주의 형태학적 특성을 규명하고자 위상차 현미경 소견, H & E 염색, Papanicolaou`s 염색 및 전자현미경적 방법 등을 이용한 결과 인간 상피세포 유래 종양임을 확인할 수 있다. 4. 배양세포주를 누드마우스에 이종이식시켜 종양의 형태학적 변화를 분석한 결과 형성된 종양조직은 본래의 조직소견과 유사하였으나 분화정도는 나빴다. 또한, 종양형성 능력을 파악한 결과 2주 이내에 96%의 높은 종양형성 능력을 보였다. 5. 자궁암 세포주의 glucose-6-phosphate dehydrogenase 동위효소 분석시 type B pattern을 보여 기존의 HeLa 세포주와의 실험실내 오염이 아닌것으로 판명되었다. 6. CUMC-6 종양세포주들의 염색체 분석시 대부분의 세포들은 이배수성(2n-46)을 나타내었으며 약 20%의 세포들에서 7번 염색체 하나가 더 많은 삼배수성(trisomy)을 보였다. 7. 태반단백, 호르몬 및 종양표지물질 분비여부를 검색한 결과 태반단백으로서는 B-HCG 분비를 확인하였고, 또한 종양표지물질로서는 AFP분비를 확인하였다. 8. 종양세포주의 에스트로겐 및 프로게스테론 수용체 존재여부를 분석한 결과 각각 음성으로 판정되었다. 9. 종양세포주의 인체 백혈구항원(human leukocyte antigen) 검색 결과 HLA class II phenotype 들은 DR12와 DQw3로 나타났으며, HLA class II allele specificity들은 DRB1*1202, DQA1*0601 , 및DQB1*03*들로 판명되었다. 10. 배양된 CUMC-6 세포주에서 HPV 감염여부를 검색하기 위하여 polymerase chain reaction(PCR) 을 실시한 결과 HVP 16과 HVP 18이 동시에 감염되어 있는것을 확인할 수 있었다. 11. CUMC-6 세포주에서 c-myc 유전자는 재배열 및 증폭소견들을 보여주었으나 L-myc 유전자의 재배열 및 증폭 소견들은 발견되지 않았다. 12. Polymerase chain reaction-signle strand conformation polymorphism(PCR-SSCP)방법으로 배양된 CUMC-6 세포주에서 p53 종양억제 유전자의 변이는 관찰되지 않았다. 이와같이 특징화 과정이 완료된 CUMC-6 자궁경부 상피암 세포주는 향후 한국 여성의 자궁경부암 치료와 생물학적 연구에 적절한 실험 모델이 될것으로 사료되며 자궁경부 상피암의 발생기전에 염색체 1번의 이상, c-myc 발암유전자의 변이, 및 HVP 감염등이 복합적으로 관여하는 것을 파악할 수 있었다.
A Digital-Twin-Assisted Fault Diagnosis Using Deep Transfer Learning (2019)

Digital twin is a significant way to achieve smart manufacturing, and provides a new paradigm for fault diagnosis. Traditional data-based fault diagnosis methods mostly assume that the training data and test data are following the same distribution and can acquire sufficient data to train a reliable diagnosis model, which is unrealistic in the dynamic changing production process. In this paper, we present a two-phase digital-twin-assisted fault diagnosis method using deep transfer learning (DFDD), which realizes fault diagnosis both in the development and maintenance phases. At first, the potential problems that are not considered at design time can be discovered through front running the ultra-high-fidelity model in the virtual space, while a deep neural network (DNN)-based diagnosis model will be fully trained. In the second phase, the previously trained diagnosis model can be migrated from the virtual space to physical space using deep transfer learning for real-time monitoring and predictive maintenance. This ensures the accuracy of the diagnosis as well as avoids wasting time and knowledge. A case study about fault diagnosis using DFDD in a car body-side production line is presented. The results show the superiority and feasibility of our proposed method.
Serial Neuropsychological Assessment and Magnetic Resonance Imaging Analysis in Multiple Sclerosis (1997)

During a 1-year period mean cognitive performance did not worsen. Automated volumetric MRI measures of total lesion volume and brain to intracranial cavity volume ratio correlated with neuropsychological performance, especially in patients with chronic progressive MS. Worsening MRI lesion burden correlated with cognitive decline.
Addressing FinFET metrology challenges in 1× node using tilt-beam critical dimension scanning electron microscope (2014)

At 1× node, a three-dimensional (3-D) FinFET process raises a number of new metrology challenges for process control, including gate height and fin height. At present, there is a metrology gap in inline in-die measurement of these parameters. To fill this metrology gap, in-column beam tilt has been implemented on Applied Materials V4i+ critical dimension scanning electron microscope for height measurement. Low-tilt (5 deg) and high-tilt (14 deg) beam angles have been calibrated to obtain the height and the sidewall angle information. Evaluation of its feasibility and production worthiness is done with applications in both gate height and fin height measurements. Transmission electron microscope correlation with an R2 equal to 0.89 and a precision of 0.81 nm have been achieved on various in-die features in a gate height application. The initial fin height measurement shows less accuracy (R2 being 0.77) and precision (1.49 nm) due to greater challenges brought by the fin profile, yet it is promising for the first attempt. Sensitivity to design of experiment offset die-to-die and in-die variations is demonstrated in both gate height and fin height. The process defect is successfully captured with inline gate height measurement. This is the first successful demonstration of inline in-die gate height measurement for a 14-nm FinFET process control.
Automating the metamodeling process (1997)

Model abstraction using metamodeling has demonstrated the capability to facilitate software reuse, large scale model integration, verification, and validation.
Korean Outbound Tourism: Australia's Response (1997)

Abstract During the period 1988 to 1995 Korean outbound travel increased by 526% to 3,818,740 in 1995. The rapidity of this increase has caught many destinations unprepared. One such example is Australia which has only recently recognised the potential of Korean tourism. Australia's tourism industry has yet to recognise that Korean tourists have expectations that differ from those of other Asian visitors and as a result has failed to provide a product that lives up to the promotional images of Australia contained in tourism marketing campaigns. Issues such as cuisine, language difficulties and poor itineraries are identified as major problems. This article will examine the problems Australia faces in developing a range of services and products suitable for Korean tourists.
Log analysis in cloud computing environment with Hadoop and Spark (2013)

Log is the main source of the system operation status, user behavior analysis etc. Log analysis system needs not only the massive and stable data processing ability but also the adaptation to a variety of scenarios under the requirement of efficiency, which can't be achieved from standalone analysis tools or even single cloud computing framework. We present a unified cloud platform for batch log data analysis with the combination of Hadoop and Spark. Hadoop provides a distributed file system and off-line batch computing framework, while the computing pattern in Spark is based on distributed memory. The joint of Hadoop, Spark and the data warehouse and analysis tools of Hive and Shark makes it possible to provide a unified cloud platform with batch analysis and in-memory computing capacity in order to process log in a high available, stable and efficient way.
Human Papillomavirus Type 31b Infection of Human Keratinocytes and the Onset of Early Transcription (2002)

Human papillomaviruses (HPVs) cause a number of human tumors and malignancies, including cervical cancers. Epithelial differentiation is required for the complete HPV life cycle and can be achieved using the organotypic (raft) culture system. The CIN-612 9E cell line maintains episomal copies of HPV type 31b (HPV31b), an HPV type associated with cervical cancers. When grown in the raft system, CIN-612 9E cells form a differentiated epithelium such that infectious virions can be synthesized. Many aspects of the later stages of the HPV31b life cycle have been investigated in CIN-612 9E raft tissues. We used a biologically contained homogenization system for efficient virion extraction from raft epithelial tissues. Purified HPV31b virions were used to infect low-passage-number human foreskin keratinocytes and a variety of epithelial cell lines. Newly synthesized, spliced HPV31b transcripts were detected by reverse transcription and PCR (RT-PCR) following HPV31b infection. HPV31b infection was most efficient and reproducible in HaCaT cells. The onset of viral transcription following infection was also investigated using RT-PCR techniques. Spliced E1(*)I,E2 RNAs were present as early as 4 h postinfection (p.i.), whereas the other major viral transcripts were detected by 8 to 10 h p.i. Furthermore, we characterized the structures and temporal expression of seven novel spliced early transcripts expressed following infection.
Optimal control and robust estimation for ocean wave energy converters (2013)

This thesis deals with the optimal control of wave energy converters and some associated observer design problems. The first part of the thesis will investigate model predictive control of an ocean wave energy converter to maximize extracted power. A generic heaving converter that can have both linear dampers and active elements as a power take-off system is considered and an efficient optimal control algorithm is developed for use within a receding horizon control framework. The optimal control is also characterized analytically. A direct transcription of the optimal control problem is also considered as a general nonlinear program. A variation of the projected gradient optimization scheme is formulated and shown to be feasible and computationally inexpensive compared to a standard nonlinear program solver. Since the system model is bilinear and the cost function is not convex quadratic, the resulting optimization problem is shown not to be a quadratic program. Results are compared with other methods like optimal latching to demonstrate the improvement in absorbed power under irregular sea condition simulations. In the second part, robust estimation of the radiation forces and states inherent in the optimal control of wave energy converters is considered. Motivated by this, low order H∞ observer design for bilinear systems with input constraints is investigated and numerically tractable methods for design are developed. A bilinear Luenberger type observer is formulated and the resulting synthesis problem reformulated as that for a linear parameter varying system. A bilinear matrix inequality problem is then solved to find nominal and robust quadratically stable observers. The performance of these observers is compared with that of an extended Kalman filter. The robustness of the observers to parameter uncertainty and to variation in the radiation subsystem model order is also investigated. This thesis also explores the numerical integration of bilinear control systems with zero-order hold on the control inputs. Making use of exponential integrators, exact to high accuracy integration is proposed for such systems. New a priori bounds are derived on the computational complexity of integrating bilinear systems with a given error tolerance. Employing our new bounds on computational complexity, we propose a direct exponential integrator to solve bilinear ODEs via the solution of sparse linear systems of equations. Based on this, a novel sparse direct collocation of bilinear systems for optimal control is proposed. These integration schemes are also used within the indirect optimal control method discussed in the first part.
[Possibilities of management of dyspeptic symptoms in the immediate postoperative period]. (1994)

Analysis of the postoperative course of 1276 patients has shown that the incidence of nausea and vomiting in the first hours after surgical intervention does not depend on the mode of analgesia. Dyspepsia in the immediate postoperative period occurred in more than 1/3 of the patients after surgery on the bile duct. Addition of metoclopramide or dimetpromide to premedication helped reduce the incidence of postoperative vomiting. An antiemetic drug should be an obligatory component of premedication.
Recent developments in SLICOT library and related tools (2011)

The latest developments of the SLICOT Library and associated tools are discussed, and issues related to its future evolution are summarized. Structure-exploiting solvers for skew-Hamiltonian/Hamiltonian matrix pencils have been added. Possible applications include the computation of L ∞ -or H ∞ -norms of linear time-invariant multivariable systems, and solution of algebraic matrix Riccati equations.
Efficient Spherical Harmonic Evaluation (2013)

The real spherical harmonics have been used extensively in computer graphics, but the conventional representation is in terms of spherical coordinates and involves expensive trigonometric functions. While the polynomial form is often listed for low orders, directly evaluating the basis functions independently is inefficient. This paper will describe in detail how recurrence relations can be used to generate pre-factored evaluation code that is smaller, more efficient, and presents a performance comparison of several alternative techniques to evaluate the spherical harmonics. 1.
Quantitative Study of Macroscopic Quantum Tunneling in a dc SQUID: A System with Two Degrees of Freedom (2002)

To test whether the theory of macroscopic quantum tunneling (MQT) is applicable to systems with 2 degrees of freedom, we experimentally investigated the switching current distribution of a dc SQUID. Using sample parameters determined from measurements at T=4.2 K, we are able to make quantitative comparison to the theories from 8 mK to 4.2 K. The excellent agreement between the data and the MQT theory demonstrates that tunneling from the zero-voltage state of the dc SQUID is well described by the quantum mechanics.
An evaluation of the acidified glycerol lysis test (1986)

The acidified glycerol lysis test (AGLT), as a screening procedure for spherocytosis, has been assessed for sensitivity and specificity. AGLT identified 24 of 26 subjects with hereditary spherocytosis and produced 19 abnormal AGLTs out of a total of 52 normal blood donors. The claims for the test as being both 100% sensitive and specific could not be confirmed.
Application of sol-gel films in optical wavelengthfilters (1994)

The authors report the use of a sol-gel film as an overlay guide on an integrated optic buried channel waveguide to selectively couple out near-infra-red wavelengths. The coupling wavelength is shown to be dependent on the thickness and index of the overlay and on the polarisation of the guided light.
Simultaneous spatial and frequency-domain filtering at the antenna inputs achieving up to +10dBm out-of-band/beam P<sub>1dB</sub> (2013)

Multi-antenna transceivers with beam-forming are recently gaining interest for low GHz frequencies (<;6GHz) [1-4]. In the antenna beam, (phase-shifted) signals from multiple antennas add constructively, improving SNR, while out-of-beam signals add destructively (i.e. spatial filtering). Usually the summation point is behind some gain blocks, which then need to be capable of handling strong signals. To improve the input-referred compression point P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> , a fully passive switched-capacitor approach was presented in [4], providing P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> =+2dBm, but at a high noise penalty: NF=18dB. Here we propose to sum immediately at the baseband capacitors of passive mixer-first switched-RC downconverters. We show that this can render a direction-dependent RF impedance (spatial filtering) together with RF bandpass frequency filtering at lower noise and higher P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> .
High performance scaled flash-type EEPROMs fabricated by <i>in situ</i> multiple rapid thermal processing (1993)

Flash-type EEPROMs were fabricated for the first time by in situ multiple rapid thermal processing (RTP) modules. In the Letter, rapid thermal oxynitridation tunnel oxide (RTONO) formation followed by in situ arsenic (As)-doped floating gate polysilicon growth by rapid thermal chemical vapour deposition (RTCVD) were introduced. The flash cell indicates only 20% narrowing of the Vt window after 5 × 104 program/erase cycle stress. Moreover, there is a higher breakdown field of the ONO film on the floating-gate polysilicon film owing to extremely flat poly-Si surface. Thus, the in situ multiple RTP technology is the key for future flash memory fabrication processes.