gebhart/patrepeval huggingface dataset:
Linearly augmented deep neural network (2016)

Deep neural networks (DNN) are a powerful tool for many large vocabulary continuous speech recognition (LVCSR) tasks. Training a very deep network is a challenging problem and pre-training techniques are needed in order to achieve the best results. In this paper, we propose a new type of network architecture, Linear Augmented Deep Neural Network (LA-DNN). This type of network augments each non-linear layer with a linear connection from layer input to layer output. The resulting LA-DNN model eliminates the need for pre-training, addresses the gradient vanishing problem for deep networks, has higher capacity in modeling linear transformations, trains significantly faster than normal DNN, and produces better acoustic models. The proposed model has been evaluated on TIMIT phoneme recognition and AMI speech recognition tasks. Experimental results show that the LA-DNN models can have 70% fewer parameters than a DNN, while still improving accuracy. On the TIMIT phoneme recognition task, the smaller LA-DNN model improves TIMIT phone accuracy by 2% absolute, and AMI word accuracy by 1.7% absolute.
Novel regimen through combination of memantine and tea polyphenol for neuroprotection against brain excitotoxicity (2008)

NMDA receptors are abundant, ubiquitously distributed throughout the brain, fundamental to excitatory neurotransmission, and critical for normal CNS function. However, excessive glutamate overstimulates NMDA receptors, leading to increased intracellular calcium and excitotoxicity. Mitochondrial dysfunction associated with loss of Ca(2+)homeostasis and enhanced cellular oxidative stress has long been recognized to play a major role in cell damage associated with excitotoxicity. In this experiment, we attempted to explore whether treatment with memantine (an NMDA receptor antagonist) and tea polyphenol (an antioxidant and anti-inflammatory agent), either alone or in combination, is effective in neuroprotection in a mouse excitotoxic injury model. Memantine (10 mg/kg/day), tea polyphenol (60 mg/kg/day), or a combination (memantine 5 mg/kg/day plus tea polyphenol 30 mg/kg/day) was administered by oral gavage for 2 consecutive days before causing excitotoxic injury. Mice received a 0.3-microL NMDA [335 mM (pH 7.2)] injection into the left striatum. Locomotor activity was assessed 24 hr before and after excitotoxic injury. Brain synaptosomes were harvested 24 hr after excitotoxic injury for assessment of Na(+), K(+)-ATPase and Mg(2+)-ATPase activity, reactive oxygen species production, mitochondrial membrane potential (Delta Psi m), mitochondrial reductase activity (MTT test), and Ca(2+)concentration. The results showed that treatment with memantine could significantly rescue mitochondrial function by attenuating the decreased mitochondrial membrane potential (Delta Psi m) and mitochondrial reductase activity in mouse excitotoxic injury. Treatment with tea polyphenol could significantly decrease the increased production of synaptosomal reactive oxygen species (ROS) and thus reduced the deteriorative ROS-sensitive Na(+), K(+)-ATPase and Mg(2+)-ATPase activity. However, neither memantine nor tea polyphenol alone could significantly improve the impaired locomotor activity unless treatment was combined. Combined treatment with memantine and tea polyphenol could significantly protect mice against excitotoxic injury by reducing the increased synaptosomal ROS production, attenuating the decreased Na(+), K(+)-ATPase and Mg(2+)-ATPase activity, the mitochondrial membrane potential (Delta Psi m), the mitochondrial reductase activity, and the increased synaptosomal Ca(2+)concentration. In addition, the impairment in locomotor activity was also significantly improved. Therefore, the combined treatment of memantine and tea polyphenol is more effective in neuroprotection than either memantine or tea polyphenol alone in mouse excitotoxic injury. These findings provide useful information about the potential application of memantine and tea polyphenols in preventing clinical excitotoxic injury such as brain trauma, brain ischemia, epilepsy, and Alzheimer's disease.
A Comparison of Photosensor-Controlled Electronic Dimming Systems in a Small Office (2000)

(2000). A Comparison of Photosensor-Controlled Electronic Dimming Systems in a Small Office. Journal of the Illuminating Engineering Society: Vol. 29, No. 1, pp. 66-80.
Film compression bandage (2015)

Summary Purpose: Textile compression stockings or bandages are limited in comfort; they do not allow uninterrupted wearing. A novel elastic film bandage was evaluated regarding practicability, patient comfort and effect on vein regression. Main endpoint was the frequency of symptomatic inflammatory reactions. Methods: In a comparative pilot study, a compression film bandage (CFB, investigational) comprising an elastic, self-adhesive breathable polymer film of d <20 µm was continuously worn for 14 d after foam sclero-therapy. Inclusion: 62 patients (26–68 y.) frequently doing sports and taking daily showers, 90 legs with superficial varicosities, 5–12 mm ø (MW: 7.3 mm), randomized to A) CFB + medical compression stocking (MCS), B) MCS alone, C) CFB alone. Follow-up examinations including ultrasound and photography were performed after 2, 4 and 8 weeks. Results: Continuous wearing time of 14 days was completed in 57/60 cases with CFB (95.0 %, A+C), while 3/60 (5.0 %) finished wearing after 8–10 d. There were no adverse skin reactions except minor irritations at the upper edge (n = 2). Vein diameters were reduced within 14 days by 29–54 % (mean: 43.5 %) in group A, 16–44% (mean: 39.1 %) in group B, and 24–50 % (mean: 37.3 %) in group C. Symptomatic inflammation, indu-ration or discolouration was observed within 28 days in 5/60 cases (8.3 %) when using CFB (A, C) versus 19/30 (63.3%) related to stocking compression (B). Comfort was rated by the patients 6.6 (A), 4.3 (B) and 9.2 (C) on a 10 degree scale. This difference was statistically highly significant (p <0.01). Conclusions: The film bandage is an effective and safe compression modality. For superficial varicosities the adhesive bond to the skin seems to be relevant additional to the elastic properties. The device significantly improves vein regression of foam-treated superficial varicosities when combined with compression stockings or even as stand-alone modality. Continuous wearing for two weeks is well tolerated. The bandage may also offer an alternative for patients not tolerating textile compression media, or during summer.
Abstract 2798: Enhanced HIF1α inhibition through dual inhibition of CDK and HSP90 (2016)

Abstract A prevalent characteristic of solid tumors is the presence of hypoxic areas. Intratumoral hypoxia plays a well-known role in chemotherapy and radiotherapy resistance and is associated with poor prognosis as well as enhanced metastasis. Hypoxia-inducible factor 1α (HIF1α) is a major mediator of the cellular response to hypoxia, which promotes malignant proliferation and progression in cancers. HIF-1α expression is increased in a variety of tumors but this is not restricted to hypoxic regions. Understanding and targeting the mechanism of cancer-related HIF1α stabilization may help to improve current cancer treatments. We have previously shown that cyclin-dependent kinase 1 (CDK1) stabilizes HIF1α through direct phosphorylation of its Ser668 residue in a Von Hippel-Lindau (VHL)-independent manner both under hypoxia and at G2/M under normoxia (Warfel et al., Cell Cycle, 2013). Another previously acknowledged VHL-independent HIF1α stabilizer is the heat shock protein 90 (HSP90) that has been correlated with adverse prognosis and used as a therapeutic target in cancer. We investigated potential crosstalk between CDK1-mediated and HSP90-mediated HIF1α stabilization and the potential for therapeutic targeting. We found that under hypoxia, the interaction between HSP90 and HIF1α proteins is impaired by CDK1 inhibition in HCT116 colon cancer cells. Moreover, the level of HIF1α protein is increased by heat shock (40°C) treatment (as compared to 37°C), which can be reversed by the treatment with the HSP90 inhibitor, geldanamycin. Interestingly, administration of the CDK1 inhibitor, Ro-3306, is also able to decrease heat shock-induced HIF1α. Our results suggest that CDK1 activity may contribute to HSP90-mediated HIF1α stabilization. On the other hand, HIF1α level is decreased by HSP90 inhibition under hypoxia, which can be further reduced by the combination of HSP90 inhibition and CDK1 inhibition or knockdown. The joint inhibitory effect of CDK1 and HSP90 is observed in other cancer cell lines. In addition, we evaluated the combinational treatment of CDK4/HSP90 inhibition and found it robustly suppresses HIF1α expression in glioblastoma cell lines (i.e. T98G and SNB19). Ongoing studies are examining the biological function of CDK/HSP90 dual inhibition on cancer cell invasiveness as well as effects on cell viability. Our findings provide a rationale for targeting HIF1α through a novel combination of CDK and HSP90 inhibitors, a therapeutic strategy with clinical implications. Citation Format: Shuai Zhao, David T. Dicker, Wafik S. El-Deiry. Enhanced HIF1α inhibition through dual inhibition of CDK and HSP90. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2798.
An Assessment of Module Cooling Enhancement With Thermoelectric Coolers (2005)

The trend towards increasing heat flux at the chip and module level in computers is continuing. This trend coupled with the desire to increase performance by reducing chip operating temperatures presents a further challenge to thermal engineers. This paper will provide an assessment of the potential for module cooling enhancement with thermoelectric coolers. A brief background discussion of thermoelectric cooling is provided citing some of the early history of thermoelectrics as well as more recent developments from the literature. An example analyzing cooling enhancement of a multichip module package with a thermoelectric cooler is discussed. The analysis utilizes closed form equations incorporating both thermoelectric cooler parameters and package level thermal resistances to relate allowable module power to chip temperature. Comparisons are made of allowable module power with and without thermoelectric coolers based upon either air or water module level cooling. These results show that conventional thermoelectric coolers are inadequate to meet the requirements. Consideration is then given to improvements in allowable module power that might be obtained through increases in the thermoelectric figure of merit ZT or miniaturization of the thermoelectric elements.
The effect of thin film/substrate radii on the Stoney formula for thin film/substrate subjected to nonuniform axisymmetric misfit strain and temperature (2006)

Current methodologies used for the inference of thin film stress through curvature measurements are strictly restricted to stress and curvature states which are assumed to remain uniform over the entire film/substrate system.There are recent studies of film/substrate systems subjected to nonuniform but axisymmetric misfit strain and temperature changes.The film stresses were found to depend nonlocally on system curvatures (that is, depend on the full-field curvatures).A very simple stress-curvature relation was established, but it is limited to thin film and substrate of same radius.We extend the analysis to thin film and substrate of different radii.Remarkably the same simple stress-curvature relation still holds regardless of the film/substrate radii mismatch.
Fair and efficient router congestion control (2004)

Congestion is a natural phenomenon in any network queuing system, and is unavoidable if the queuing system is operated near capacity. In this paper we study how to set the rules of a queuing system so that all the users have a self-interest in controlling congestion when it happens.Routers in the internet respond to local congestion by dropping packets. But if packets are dropped indiscriminately, the effect can be to encourage senders to actually increase their transmission rates, worsening the congestion and destabilizing the system. Alternatively, and only slightly more preferably, the effect can be to arbitrarily let a few insistent senders take over most of the router capacity.We approach this problem from first principles: a router packet-dropping protocol is a mechanism that sets up a game between the senders, who are in turn competing for link capacity. Our task is to design this mechanism so that the game equilibrium is desirable: high total rate is achieved and is shared widely among all senders. In addition, equilibrium should be reestablished quickly in response to changes in transmission rates. Our solution is based upon auction theory: in principle, although not always in practice, we drop packets of the highest-rate sender, in case of congestion. We will prove the game-theoretic merits of our method. We'll also describe a variant of the method with some further advantages that will be supported by network simulations.
Post-DfT-insertion retiming for delay recovery on inter-die paths in 3D ICs (2013)

Pre-bond known-good-die (KGD) test is necessary to ensure stack yield for the future adoption of 3D ICs. Die wrappers that contain boundary registers at the interface between dies have been proposed as a solution for known-good-die (KGD) test. It has been shown in the literature that if gated scan flops (GSFs) are substituted for traditional scan flops in the boundary register, then both pre-bond TSV and pre-bond scan test can be performed. The drawback of die wrappers is that two clocked stages are added to each path that crosses a die boundary. In this paper, a bypass mode is added to GSFs to avoid the extra clock stages and retiming is used to recover the additional delay added to through-silicon-via (TSV) paths by design-for-test (DfT) insertion. The proposed method is evaluated through simulations using a logic-on-logic 3D benchmark. Results show that in most cases, retiming at both the die-level and stack-level is sufficient for recovering the delay added by wrapper boundary cells. Stuck-at ATPG is performed to demonstrate that wrapper insertion and retiming have little impact on pattern count. The area overhead due to wrapper insertion is shown to increase as a circuit is partitioned across an increasing number of stack layers, but the area overhead can be reduced using retiming.
A Device Structure and Spatial Spectrum for Checker-Pattern CCD Color Camera (1978)

In order to develop practical color cameras with useful resolution, a novel image processing and charge-coupled device (CCD) structure is proposed which results in shrinking chip size and easing photolithography. The resolution of CCD cameras is limited by the aliasilrng errors associated with spatially discrete sampling on a photosensing area. The photosensing array arranged in a two-dimensional face-centered rectangular lattice scheme, and the spatial offsetting technique among three CCD's avoid undesirable signal carriers accompanied by aliasing errors. A unique signal processing about vertical correlation of an image is put to use, in order to reduce spurious effects of aliasing. These image processing techniques are theoretically treated on a spectrum space. The photosensing array arranged in a face-centered rectangular lattice scheme is successfully implemented with a zigzag-transfer CCD with checker-pattern sensing sites, which relax some of the lithography requirements and improve image qualities. By means of the zigzag-transfer CCD structure and the image processing, the resolution of color camera has been expanded by a factor of 2.5, compared with that of the conventional CCD cameras employing the same number of pixels. According to the theory, the factor may be increased further up to three or four.
Min-Sum Decoder Architectures With Reduced Word Length for LDPC Codes (2009)

In this paper, we propose an improvement of the normalized min-sum (MS) decoding algorithm and novel MS decoder architectures with reduced word length using nonuniform quantization schemes for low-density parity-check (LDPC) codes. The proposed normalized MS algorithm introduces a more exact adjustment with two optimized correction factors for check-node-updating computations, while the conventional normalized MS algorithm applies only one correction factor. The proposed algorithm provides a significant performance gain without any additional computation or hardware complexity. The finite word-length analysis in implementing an LDPC decoder is a very important factor since it directly impacts the size of memory to store the intrinsic and extrinsic messages and the overall hardware area in the partially parallel LDPC decoder. The proposed nonuniform quantization scheme can reduce the finite word length while achieving similar performances compared to a conventional quantization scheme. From simulation results, it is shown that the proposed 4-bit nonuniform quantization scheme achieves an acceptable decoding performance, unlike the conventional 4-bit uniform quantization scheme. Finally, the proposed MS decoder architectures by the nonuniform quantization scheme provide significant reductions of 20% and up to 8% for the memory area and combinational logic area, respectively, compared to the conventional 5-bit ones.
Design of 5-Core Multicore Fibers with Optimized Fiber Design for Practical Applications (2019)

Design of a 5-core MCF is investigated. Feasibility of applying a standard SMF type core which has good productivity to the 5-core MCF is suggested by optimized fiber structure and operation wavelength.
Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk (2003)

This study investigates the influence of genetic variation of the estrogen receptor alpha (ESR1) gene locus on several bone parameters in 2042 individuals of The Rotterdam Study, a prospective population-based cohort study of elderly subjects. We analysed three polymorphic sites in the 5' region of the ESR1 gene; a (TA)(n)-repeat in the promoter region, and molecular haplotypes of the PvuII and XbaI RFLPs in intron 1, and inferred long-range haplotypes (LRH) thereof. We observed only three of the possible four PvuII-XbaI haplotypes in our population. A comparison with other Caucasian populations showed similar haplotype frequencies, while in Asian and African populations these were different. Linkage disequilibrium (LD) analysis between the PvuII-XbaI haplotype and the (TA)(n) repeat showed strong LD between the two sites. Reconstruction of long range haplotypes over the entire 5' region, revealed six frequent LRH. In men, we did not observe an association between the ESR1 polymorphisms studied and bone parameters. In women, we demonstrated an allele dose effect of haplotype "px" (P=0.003) and a low number of (TA)(n) repeats (P=0.008) with decreased lumbar spine bone mineral density (BMD) (4.8% lower BMD in women homozygous for haplotype "px", representing 28% of the population, compared with homozygous non-carriers) and decreased vertebral bone area (2.3% difference between extreme genotypes; P=0.016). Most importantly, we found an increased vertebral fracture risk with evidence for an allele dose effect with an odds ratio of 2.2 (95%CI 1.3-3.5) for haplotype "px", and 2.0 (1.5-3.2) for a low number of (TA)(n) repeats. The ESR1 genotype dependent fracture risk is largely independent of BMD and bone area. Combination of risk alleles at both loci by long-range haplotyping improved the associations slightly, but because of the strong LD between the two polymorphic sites, we were unable to determine if any particular polymorphic site is driving the associations found. We conclude that ESR1 polymorphism in the 5' (promoter) region is associated with vertebral fracture risk, lumbar spine BMD and vertebral bone area in postmenopausal women, but not in men. The molecular mechanism underlying this association needs further study.
Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides (2012)

Selectively fluorinated molecules are important as materials, pharmaceuticals, and agrochemicals, but their synthesis by simple, mild, laboratory methods is challenging. We report a straightforward method for the cross-coupling of aryl and vinyl iodides with a difluoromethyl group generated from readily available reagents to form difluoromethylarenes and difluoromethyl-substituted alkenes. The reaction of electron-neutral, electron-rich, and sterically hindered aryl and vinyl iodides with the combination of CuI, CsF and TMSCF(2)H leads to the formation of difluoromethyl-substituted products in high yield with good functional group compatibility. This transformation is surprising, in part, because of the prior observation of the instability of CuCF(2)H.
Sub-5V Germanium Waveguide Avalanche Photodiode based 25 Gb/s 1310 nm Optical Receiver (2015)

We demonstrate low-voltage waveguide-coupled germanium avalanche photodetectors (APDs) with a gain×bandwidth product of 140 GHz at -5 V. An optical receiver based on such an APD operating up to 25 Gb/s is demonstrated.
Acyltransferases And Uses Thereof In Fatty Acid Production (Patent US 9388437 B2) (2016)

The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucletides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.\n\n
MaxSense (2021)

Detection of hardware Trojans is vital to ensure the security and trustworthiness of System-on-Chip (SoC) designs. Side-channel analysis is effective for Trojan detection by analyzing various side-channel signatures such as power, current, and delay. In this article, we propose an efficient test generation technique to facilitate side-channel analysis utilizing dynamic current. While early work on current-aware test generation has proposed several promising ideas, there are two major challenges in applying it on large designs: (i) The test generation time grows exponentially with the design complexity, and (ii) it is infeasible to detect Trojans, since the side-channel sensitivity is marginal compared to the noise and process variations. Our proposed work addresses both challenges by effectively exploiting the affinity between the inputs and rare (suspicious) nodes. The basic idea is to quickly find the profitable ordered pairs of test vectors that can maximize side-channel sensitivity. This article makes two important contributions: (i) It proposed an efficient test generation algorithm that can produce the first patterns in the test vectors to maximize activation of suspicious nodes using an SMT solver, and (ii) it developed a genetic-algorithm based test generation technique to produce the second patterns in the test vectors to maximize the switching in the suspicious regions while minimizing the switching in the rest of the design. Our experimental results demonstrate that we can drastically improve both the side-channel sensitivity (62× on average) and time complexity (13× on average) compared to the state-of-the-art test generation techniques.
Sprint (2011)

Remote data access latency is a significant performance bottleneck in many modern programs that use remote databases and web services. We present Sprint - a run-time system for optimizing such programs by prefetching and caching data from remote sources in parallel to the execution of the original program. Sprint separates the concerns of exposing potentially-independent data accesses from the mechanism for executing them efficiently in parallel or in a batch. In contrast to prior work, Sprint can efficiently prefetch data in the presence of irregular or input-dependent access patterns, while preserving the semantics of the original program.