gebhart/patrepeval huggingface dataset:
Kruppel-Like Factor 4 Is Essential for Inflammatory Monocyte Differentiation In Vivo. (2007)

Abstract Several members of the Kruppel-like factor (KLF) family of transcription factors play important roles in differentiation, survival, and trafficking of blood and immune cell types. We demonstrate here that hematopoietic cells from KLF4−/− fetal livers (FL) contained normal numbers of functional hematopoietic progenitor cells, were radioprotective, and performed as well as KLF4+/+ cells in competitive repopulation assays. However, hematopoietic “KLF4−/− chimeras” generated by transplantation of KLF4−/− FL cells into lethally irradiated wild-type (wt) mice completely lacked circulating inflammatory (CD115+Gr1+) monocytes, and had reduced numbers of resident (CD115+Gr1−) monocytes. While the numbers and function of peritoneal macrophages were normal in KLF4−/− chimeras, bone marrow monocytic cells from KLF4−/− chimeras expressed lower levels of key trafficking molecules and were more apoptotic. Thus, our in vivo loss-of-function studies demonstrate that KLF4, previously shown to mediate proinflammatory signaling in human macrophages in vitro, is essential for differentiation of mouse inflammatory monocytes, and is involved in the differentiation of resident monocytes. In addition, inducible expression of KLF4 in the HL60 human acute myeloid leukemia cell line stimulated monocytic differentiation. The inflammation-selective effects of loss-of-KLF4 and the gain-of-KLF4-induced monocytic differentiation in HL60 cells identify KLF4 as a key regulator of monocytic differentiation and a potential target for translational immune modulation.
COVID-19 and Cardiovascular Disease (2020)

Coronavirus disease 2019 (COVID-19) is a global pandemic affecting 185 countries and >3 000 000 patients worldwide as of April 28, 2020. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2, which invades cells through the angiotensin-converting enzyme 2 receptor. Among patients with COVID-19, there is a high prevalence of cardiovascular disease, and >7% of patients experience myocardial injury from the infection (22% of critically ill patients). Although angiotensin-converting enzyme 2 serves as the portal for infection, the role of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers requires further investigation. COVID-19 poses a challenge for heart transplantation, affecting donor selection, immunosuppression, and posttransplant management. There are a number of promising therapies under active investigation to treat and prevent COVID-19.
Riluzole: a therapeutic strategy in Alzheimer’s disease by targeting the WNT/β-catenin pathway (2020)

Alzheimer's disease (AD) is a neurodegenerative disease, where the etiology remains unclear. AD is characterized by amyloid-(Aβ) protein aggregation and neurofibrillary plaques deposits. Oxidative stress and chronic inflammation have been suggested as causes of AD. Glutamatergic pathway dysregulation is also mainly associated with AD process. In AD, the canonical WNT/β-catenin pathway is downregulated. Downregulation of WNT/β-catenin, by activation of GSK-3β-induced Aβ, and inactivation of PI3K/Akt pathway involve oxidative stress in AD. The downregulation of the WNT/β-catenin pathway decreases the activity of EAAT2, the glutamate receptors, and leads to neuronal death. In AD, oxidative stress, neuroinflammation and glutamatergic pathway operate in a vicious circle driven by the dysregulation of the WNT/β-catenin pathway. Riluzole is a glutamate modulator and used as treatment in amyotrophic lateral sclerosis. Recent findings have highlighted its use in AD and its potential increase power on the WNT pathway. Nevertheless, the mechanism by which Riluzole can operate in AD remains unclear and should be better determine. The focus of our review is to highlight the potential action of Riluzole in AD by targeting the canonical WNT/β-catenin pathway to modulate glutamatergic pathway, oxidative stress and neuroinflammation.
Axial Length and Associated Factors in Children: The Shandong Children Eye Study (2016)

In children in the less developed Eastern Chinese province of Shandong, the prevalence of high axial myopia was >10% among 16-year-olds. A modifiable factor associated with higher prevalence of high axial myopia was less time spent outdoors.
Formation of PtSi in the presence of W and Al (1988)

The formation of PtSi is studied in the presence of W and Al using the Al/W/Pt/Si structure, with 1000-Å W acting as the barrier layer. The PtSi layer formed stays intact at 400 °C, starts to react with Al around 450 °C, and is completely converted to PtAl2 at 500 °C, with the released Si migrating to the surface. In contrast, using the W/Pt/Si structure without an Al layer, the PtSi formed remains little changed up to about 600 °C. The W-Pt interface of the binary W/Pt structure shows no interaction up to at least 600 °C. The results are compared with those using the Al/Pt/Si structure, and their relation to contact metallurgies is discussed.
THE ROLE OF RHEOLOGICAL ADDITIVES IN PROTECTIVE COATINGS (1989)

The article attempts to provide an understanding of what rheological additives do and how the various types are suited or not suited for use in protective coatings. Each generic class of rheological additive has its strengths and weaknesses, and the coatings formulator must choose the additive based on the desired package appearance, application and end use properties. The article discusses pigment suspension, package viscosity, application viscosity, post-application viscosity, and the general properties of rheological additive classes. Solvent-based systems (organoclays, castor-based organics, polyolefin-based organics, fumed silica), and water-based systems (alkali-swellable acrylics, polyether polyurethanes) are covered.
Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse (2014)

Rituximab (RTX), a chimeric IgG1 monoclonal antibody directed against the CD20 antigen, has revolutionized the treatment of B-cell malignancies. Nevertheless, the relapsed/refractory rates are still high. One strategy to increase the clinical effectiveness of RTX is based on antibody-cytokine fusion protein (immunocytokine; ICK) vectorizing together at the tumor site the antibody effector activities and the cytokine co-signal required for the generation of cytotoxic cellular immunity. Such ICKs linking various antibody formats to interleukin (IL)-2 are currently being investigated in clinical trials and have shown promising results in cancer therapies. IL-15, a structurally-related cytokine, is now considered as having a better potential than IL-2 in antitumor immunotherapeutic strategies. We have previously engineered the fusion protein RLI, linking a soluble form of human IL-15Rα-sushi+ domain to human IL-15. Compared with IL-15, RLI displayed better biological activities in vitro and higher antitumor effects in vivo in murine and human cancer models. In this study, we investigated the advantages of fusing RLI to RTX. Anti-CD20-RLI kept its binding capacity to CD20, CD16 and IL-15 receptor and therefore fully retained both antibody effector functions (ADCC and CDC), and the cytokine potential of RLI. In a severe combined immunodeficiency (SCID) mouse model of disseminated residual lymphoma, anti-CD20-RLI was found to induce long-term survival of 90% of mice up to at least 120 days whereas RLI and RTX, alone or in combination, just delayed the disease onset (100% of death at 28, 40 and 51 days respectively). These findings suggest that such ICK could improve the clinical efficacy of RTX, particularly in patients with refractory B-cell lymphoma.
Ultra-wide-band hybrid tellurite/silica fiber Raman amplifier (2002)

Summary form only given. We achieved the largest reported seamless gain bandwidth of 135 nm (from 1497 to 1632 nm) with a minimum gain more than 20 dB for optical fiber amplifiers with a novel hybrid tellurite/silica fiber Raman amplifier. The maximum and minimum gains in the gain-band of the amplifier were 34.6 and 22.8 dB, respectively. The noise figure was less than 8.3 dB and the output power was more than 5 dBm/ch or 14.5 dBm/total with a simple gain equalizer. The amplifier was successfully used as a pre-amplifier in an eight-channel /spl times/ 10-Gb/s transmission experiment with signal wavelengths in the S-, C-, and L-bands over an 80-km standard SMF with a BER of less than 10/sup -11/. The amplifier also provided a dispersion equalization function because it had a built-in negative-slope dispersion compensation fiber as its silica Raman gain medium.
Adrenaline in cardiac arrest: Prefilled syringes are faster (2015)

The speed of administration of adrenaline utilising a Minijet (CSL Limited, Parkville, Victoria, Australia) is faster than using adrenaline in glass ampoules presented in their plastic packaging. Removing the plastic packaging from the 1 mL (1 mg) ampoule might result in more rapid administration similar to the Minijet. Resuscitation personnel requiring rapid access to adrenaline should consider storing it as either Minijets or ampoules devoid of packaging. These results might be extrapolatable to other clinical scenarios, including pre-hospital and anaesthesia, where other drugs are required for rapid use.
Titanium oxo-clusters: precursors for a Lego-like construction of nanostructured hybrid materials (2011)

Titanium oxo-clusters, well-defined monodispersed nano-objects, are appropriate nano-building blocks for the preparation of organic-inorganic materials by a bottom up approach. This critical review proposes to present the different structures of titanium oxo-clusters referenced in the literature and the different strategies followed to build up hybrid materials with these versatile building units. In particular, this critical review cites and reports on the most important papers in the literature, concentrating on recent developments in the field of synthesis, characterization, and the use of titanium oxo-clusters for the construction of advanced hybrid materials (137 references).
Porphyromonas bennonis sp. nov., isolated from human clinical specimens (2009)

During our investigation of the bacteriology of human wound infections and abscesses, a novel anaerobic, non-spore-forming, Gram-negative bacillus was frequently isolated. On the basis of morphological and biochemical criteria, the strains were tentatively identified as belonging to the family Bacteroidaceae, but they did not appear to correspond to any recognized species of this family. Comparative 16S rRNA gene sequencing showed that the 14 novel strains were genotypically homogeneous and confirmed their placement in the genus Porphyromonas. Sequence divergence values >10 % with respect to reference Porphyromonas species demonstrated that the strains isolated represent a novel species. On the basis of biochemical criteria and phylogenetic considerations, it is proposed that these strains isolated from human sources should be assigned to a novel species of the genus Porphyromonas, named Porphyromonas bennonis sp. nov., with WAL 1926C(T) (=ATCC BAA-1629(T) =CCUG 55979(T)) as the type strain.
Pathological events in platelets of Wiskott‐Aldrich syndrome patients (1999)

The Wiskott-Aldrich syndrome (WAS) is a severe X-linked platelet/immunological disorder arising from mutations of the gene WASP. At the clinical level, the major platelet abnormalities are small size and low number, both partially correctable by splenectomy. To identify underlying pathological events, we examined WAS platelets at various stages of their lifetime. In spleen sections from WAS patients, fluorescence microscopy showed dramatic co-localization of markers of platelets (CD41) and macrophages (CD68) compared to non-thrombocytopenic controls, suggesting that WAS splenic macrophages are involved in platelet removal. Study of isolated WAS blood platelets by flow cytometry showed substantial enhancement of surface exposure of phosphatidylserine (PS), a signal for engulfment by macrophages. Isolated resting WAS platelets were also aberrantly susceptible to microparticle release, and plasma samples of WAS patients contained > 5 times normal numbers of platelet-derived microparticles which may explain the small size of circulating platelets. Measurements with the Ca2+ sensitive dye fluo-3 revealed significantly increased Ca2+ levels, 310 +/- 13 nmol/l for WAS platelets versus 106 +/- 12 nmol/l for normal platelets, and also prolongation of agonist-induced Ca2+ flux. Cumulatively, these studies identify abnormal events occurring in WAS platelets: increased Ca2+ levels and enhancement of two Ca2+ dependent processes, PS exposure and microparticle release; these abnormal events may contribute to the in vivo decrease of platelet number and reduction of platelet size in this disease.
Experimental Assessment of Casing Expansion as a Solution to Microannular Gas Migration (2014)

Abstract The objective of this research was to investigate the potential impact of expandable casing technology on the remediation of Sustained Casing Pressure (SCP). Varying magnitudes of SCP exist in the Gulf of Mexico (GOM), where over 80% of casing strings exhibiting SCP are production and surface casings, representing a great technical, economic, and environmental risk. Situations in which SCP is observed usually result in costly and frequently unsuccessful remediation efforts. The technique proposed in this project with expandable casing can be done during drilling, producing, or during the abandonment process. A unique bench-scale physical model was used to simulate expansion of a previously-cemented casing under field-like conditions. Experimental measurements obtained during low-percentage casing expansion exhibited improvement of cement integrity with significant changes in the cement sheath. Successful multi-rate flow-through experiments with nitrogen gas showed the effectiveness of this technique in complete closure of microannular gas leakage pathways, providing ideal cement remediation. If implemented, this technology has potential to become a cement remediation technique for leaks behind the casing.
Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways (2005)

Dendritic arborization and spine formation are critical for the functioning of neurons. Although many proteins have been identified recently as regulators of dendritic morphogenesis, the intracellular signaling pathways that control these processes are not well understood. Here we report that the Ras-phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway plays pivotal roles in the regulation of many aspects of dendrite formation. Whereas the PI3K-Akt-mTOR pathway alone controlled soma and dendrite size, a coordinated activation together with the Ras-mitogen-activated protein kinase signaling pathway was required for increasing dendritic complexity. Chronic inhibition of PI3K or mTOR reduced soma and dendrite size and dendritic complexity, as well as density of dendritic filopodia and spines, whereas a short-term inhibition promoted the formation of mushroom-shaped spines on cells expressing constitutively active mutants of Ras, PI3K, or Akt, or treated with the upstream activator BDNF. Together, our data underscore the central role of a spatiotemporally regulated key cell survival and growth pathway on trophic regulation of the coordinated development of dendrite size and shape.
A preliminary study of serum concentrations of soluble epidermal growth factor receptor (sErbB1), gonadotropins, and steroid hormones in healthy men and women. (2001)

Soluble ErbB (sErbB) growth factor receptors are being investigated as cancer biomarkers. Gonadotropic and steroid hormones have been shown to modulate the expression of ERBB family members in vivo. Accordingly, the range of sErbB1 values and their relationship to gonadotropic and steroid hormones need to be established in healthy subjects to provide a baseline for future clinical studies. We assayed sera from healthy men and women to determine p110 sErbB1 concentrations by acridinium-linked immunosorbent assay (ALISA). Follicle-stimulating hormone (FSH), estradiol, and testosterone concentrations were measured using the ACS:180 Immunoassay Analyzer. Luteinizing hormone (LH) and progesterone concentrations were quantified using the Access Immunoassay System. Unadjusted for age, p110 sErbB1 concentrations in healthy men and women do not differ significantly. However, sErbB1 concentrations show a strong age-gender interaction, increasing with age in men but decreasing with age in women. Consequently, sErbB1 concentrations are significantly higher in premenopausal women compared with either postmenopausal women or age-matched men and in age-matched men compared with postmenopausal women. Serum sErbB1 concentrations show significant negative associations with both FSH and LH concentrations in healthy women and a significant positive association with FSH concentrations in healthy men. Univariate linear regression models show that these respective gonadotropic hormones and age are independent predictors of sErbB1 concentrations in men and women. Multivariate models show that when age and FSH and LH concentrations are mutually adjusted for each other, they account for 22% of the variability observed in sErbB1 concentrations in healthy women. These data support the hypothesis that gonadotropic and steroid hormones may modulate ERBB1 expression in vivo and suggest that age- and gonadotropin-adjusted sErbB1 concentrations may be of clinical utility. Furthermore, these data demonstrate that gender, age, menstrual cycle phase, menopausal status, and exogenous hormone use must be considered when using serum p110 sErbB1 concentrations as cancer biomarkers.
A Secure Decentralized Trustless E-Voting System Based on Smart Contract (2019)

E-voting plays a significant role in social activities. The trust of the voting results and the privacy of each voter are always the most important concerns in designing secure e-voting system. In this paper, we design a decentralized trustless e-voting system based on the smart contract. To guarantee the correctness of the voting result, the smart contract on Blockchain is used to provide a trusted public bulletin board and trusted computing environment. To hide the identity of each voter as well as avoid multiple voting, linkable ring signature is used for each voter to group a signing ring. In addition, to make sure that all voters will see the voting result at the same time, or nobody can get it, threshold encryption without trusted third party is used to make secret-key secretly before tally stage. Moreover, the trust (power) of the voting system is separated to all voters. Even though some of them are malicious, the final result will not be influenced. The contract is deployed on the Ethereum private network. Some feasibility and cost analysis on money and time are also provided.
Chaos in Fisheries Management (1990)

Analyse des contradictions dans la reglementation de l'acces aux ressources maritimes (Etats-Unis)
Bacterial Cellulose: A Sustainable Source to Develop Value-Added Products – A Review (2016)

In recent decades, worldwide economic and environmental issues have prompted research scientists to re-direct their interests to bio-based resources, which are sustainable in nature. In this context, microbial polysaccharides, such as bacterial cellulose (BC), also known as microbial cellulose (MC), are some of the upcoming and emergent resources and have potential application in various bio- and non-bio-based sectors of the modern world. Many researchers have already established novel BC/MC production methods, and many new studies have been published on lab-scale and large-scale production aspects of BC/MC to date. To further expand the novel use of this sustainable source, significant progress toward the development of BC/MC has appeared in recent years. Specifically, there have been many publications and/or research reports on the valorization of BC/MC in the food, paper, materials, biomedical, pharmaceutical, and cosmeceutical industries, among others. This review will address the novel application aspects of BC/MC today, with the aim of demonstrating the importance of this sustainable and novel source in the development of value-added products.
Multi-Layer and Recursive Neural Networks for Metagenomic Classification (2015)

Recent advances in machine learning, specifically in deep learning with neural networks, has made a profound impact on fields such as natural language processing, image classification, and language modeling; however, feasibility and potential benefits of the approaches to metagenomic data analysis has been largely under-explored. Deep learning exploits many layers of learning nonlinear feature representations, typically in an unsupervised fashion, and recent results have shown outstanding generalization performance on previously unseen data. Furthermore, some deep learning methods can also represent the structure in a data set. Consequently, deep learning and neural networks may prove to be an appropriate approach for metagenomic data. To determine whether such approaches are indeed appropriate for metagenomics, we experiment with two deep learning methods: i) a deep belief network, and ii) a recursive neural network, the latter of which provides a tree representing the structure of the data. We compare these approaches to the standard multi-layer perceptron, which has been well-established in the machine learning community as a powerful prediction algorithm, though its presence is largely missing in metagenomics literature. We find that traditional neural networks can be quite powerful classifiers on metagenomic data compared to baseline methods, such as random forests. On the other hand, while the deep learning approaches did not result in improvements to the classification accuracy, they do provide the ability to learn hierarchical representations of a data set that standard classification methods do not allow. Our goal in this effort is not to determine the best algorithm in terms accuracy-as that depends on the specific application-but rather to highlight the benefits and drawbacks of each of the approach we discuss and provide insight on how they can be improved for predictive metagenomic analysis.
Early Prediction of Employee Attrition using Data Mining Techniques (2018)

Bill Gates was once quoted as saying, "You take away our top 20 employees and we [Microsoft] become a mediocre company". This statement by Bill Gates took our attention to one of the major problems of employee attrition at workplaces. Employee attrition (turnover) causes a significant cost to any organization which may later on effect its overall efficiency. As per CompData Surveys, over the past five years, total turnover has increased from 15.1 percent to 18.5 percent. For any organization, finding a well trained and experienced employee is a complex task, but it's even more complex to replace such employees. This not only increases the significant Human Resource (HR) cost, but also impacts the market value of an organization. Despite these facts and ground reality, there is little attention to the literature, which has been seeded to many misconceptions between HR and Employees. Therefore, the aim of this paper is to provide a framework for predicting the employee churn by analyzing the employee's precise behaviors and attributes using classification techniques.
Hemagglutinating Encephalomyelitis Coronavirus Infection in Pigs, Argentina (2008)

We describe an outbreak of vomiting, wasting, and encephalomyelitis syndrome in piglets in Argentina, caused by porcine hemagglutinating encephalomyelitis coronavirus (PHE-CoV) infection. Diagnosis was made by epidemiologic factors, pathologic features, immunohistochemistry, reverse transcription-PCR, and genomic sequencing. This study documents PHE-CoV infection in South America.