gebhart/patrepeval huggingface dataset:
Model-based adaptive resource provisioning in a web service utility (2003)

Internet service utilities host multiple server applications on a shared server cluster. A key challenge for these systems is to provision shared resources on demand to meet service quality targets at least cost. This dissertation presents a new approach to utility resource management focusing on coordinated provisioning of cluster resources, including CPU, memory and storage bandwidth. Our approach is model-based: it incorporates internal models of service behavior to predict the value of candidate resource allotments under changing load. The model-based approach enables the system to achieve important resource management goals, including differentiated service quality, performance isolation, improved content caching, and proactive allocation of surplus resources to meet performance goals. This dissertation makes significant steps in adaptive resource provisioning for web service utilities. (1) It presents a feedback-controlled framework for adaptive provisioning in an Internet data center. (2) It introduces models for predictive resource provisioning, including an algorithm and framework supporting models for proactive prediction of resource requirements. Using load estimates, our model-based approach estimates the effectiveness of the resource allotments. (3) It incorporates server energy, cache memory and storage bandwidth as primary target resources for the adaptive provisioning algorithm. (4) It presents an algorithm for determining cache hit rate based on memory size for static web services with Zipf-like object popularity distributions. It presents an algorithm to parameterize the model from on-line observations. (5) It introduces the notion of provisioning to meet customer demand using energy consumption as a component of this decision process. (6) It illustrates the effects of caching on the characteristics of request streams arriving at the enterprise edge. It also shows how caching affects request distribution policies. 
Combined, these contributions expand the understanding of memory as a provisioned resource, and advance the state of provisioning systems to incorporate pluggable resource models for flexible and accurate adaptive resource allocation.
Antihypertensive effect of an angiotensin converting enzyme inhibitory peptide from enzyme modified cheese (2008)

Two angiotensin converting enzyme (ACE)-inhibitory peptides were isolated from enzyme modified cheese (EMC) and their amino acid sequences were identified as Leu-Gln-Pro and Met-Ala-Pro. The EMC was prepared by a combination of Protease N, Umamizyme, and Flavourzyme 500L. Both peptides were derived from beta-casein, f 88-90 and f 102-104, respectively. Met-Ala-Pro showed strong ACE inhibitory activity (IC50=0.8 mum) and antihypertensive activity in spontaneously hypertensive rats (SHR) after single oral administration. The IC50 value of Met-Ala-Pro was not affected by pre-incubation with ACE, suggesting that this peptide was a true ACE-inhibitory peptide. We report here, for the first time antihypertensive peptides from EMC.
SQUID‐detected MRI at 132 μT with <i>T</i><sub>1</sub>‐weighted contrast established at 10 μT–300 mT (2004)

T(1)-weighted contrast MRI with prepolarization was detected with a superconducting quantum interference device (SQUID). A spin evolution period in a variable field between prepolarization and detection enabled the measurement of T(1) in fields between 1.7 microT and 300 mT; T(1) dispersion curves of agarose gel samples over five decades in frequency were obtained. SQUID detection at 5.6 kHz drastically reduces the field homogeneity requirements compared to conventional field-cycling methods using Faraday coil detection. This allows T(1) dispersion measurements to be easily combined with MRI, so that T(1) in a wide range of fields can be used for tissue contrast. Images of gel phantoms with T(1)-weighted contrast at four different fields between 10 microT and 300 mT demonstrated dramatic contrast enhancement in low fields. A modified inversion recovery technique further enhanced the contrast by selectively suppressing the signal contribution for a specific value of the low-field T(1).
Novel Membrane-associated Androgen Receptor Splice Variant Potentiates Proliferative and Survival Responses in Prostate Cancer Cells (2011)

Progression from the androgen-sensitive to androgen-insensitive (or castration-resistant) stage is the major obstacle for sustained effectiveness of hormonal therapy for prostate cancer. The androgen receptor (AR) and its splice variants play important roles in regulating the transcription program essential for castration resistance. Here, we report the identification of a novel AR splice variant, designated as AR8, which is up-regulated in castration-resistant prostate cancer cells. AR8 is structurally different from other known AR splice variants because it lacks a DNA binding domain and therefore, unlikely functions as a transcription factor on its own. Immunofluorescence staining revealed that AR8 was primarily localized on the plasma membrane, possibly through palmitoylation of two cysteine residues within its unique C-terminal sequence. Mutation of these putative palmitoylation sites in AR8 led to loss of its plasma membrane localization. In addition, we demonstrated that overexpression of AR8 in prostate cancer cells promoted association of Src and AR with the EGF receptor in response to EGF treatment and enhanced tyrosine phosphorylation of AR. Conversely, specific knockdown of AR8 expression in prostate cancer cells compromised EGF-induced Src activation and AR phosphorylation. This effect was accompanied with attenuation of proliferation and increased apoptosis in prostate cancer cells cultured in androgen-depleted medium. We also showed that AR8 was required for optimal transcriptional activity of AR in response to treatment of both androgen and EGF. Taken together, our results demonstrate that the membrane-associated AR8 isoform may contribute to castration resistance by potentiating AR-mediated proliferative and survival responses to hormones and growth factors.
Tandem connection monitoring in the MPLS network (2007)

A method to monitor the quality of a MPLS LSP at the user, the service provider and the network provider’s aspect is suggested. The CV packet of the MPLS OAM packets is modified, and one bit for checking the incoming error is defined, the BIP-8 byte is added to evaluate the signal quality at the service provider and the network provider level respectively. By performing the tandem connection monitoring like the above the possible conflict between network providers can be avoided as the error location will be clearly identified.
Photonic Readout of Superconducting Nanowire Single Photon Counting Detectors (2020)

Scalable, low power, high speed data transfer between cryogenic (0.1-4 K) and room temperature environments is essential for the realization of practical, large-scale systems based on superconducting technologies. A promising approach to overcome the limitations of conventional wire-based readout is the use of optical fiber communication. Optical fiber presents a 100-1,000x lower heat load than conventional electrical wiring, relaxing the requirements for thermal anchoring, and is also immune to electromagnetic interference, which allows routing of sensitive signals with improved robustness to noise and crosstalk. Most importantly, optical fibers allow for very high bandwidth densities (in the Tbps/mm<sup>2</sup> range) by carrying multiple signals through the same physical fiber (Wavelength Division Multiplexing, WDM). Here, we demonstrate for the first time optical readout of a superconducting nanowire single-photon detector (SNSPD) directly coupled to a CMOS photonic modulator, without the need for an interfacing device. By operating the modulator in the forward bias regime at a temperature of 3.6 K, we achieve very high modulation efficiency (1,000-10,000 pm/V) and a low input impedance of 500 Ω with a low power dissipation of 40 μW. This allows us to obtain optical modulation with the low, millivolt-level signal generated by the SNSPD.
Population‐specific frequencies for <i>LRRK2</i> susceptibility variants in the genetic epidemiology of Parkinson's disease (GEO‐PD) consortium (2013)

ABSTRACT Background Variants within the leucine‐rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine‐rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late‐onset sporadic disorders like Parkinson's disease. Methods The Genetic Epidemiology of Parkinson's Disease Consortium recently performed the largest genetic association study for variants in the leucine‐rich repeat kinase 2 gene across 23 different sites in 15 countries. Results Herein, we detail the allele frequencies for the novel risk factors (p.A419V and p.M1646T) and the protective haplotype (p.N551K‐R1398H‐K1423K) nominated in the original publication. Simple population allele frequencies not only can provide insight into the clinical relevance of specific variants but also can help genetically define patient groups. Conclusions Establishing individual patient‐based genomic susceptibility profiles that incorporate both risk factors and protective factors will determine future diagnostic and treatment strategies. © 2013 International Parkinson and Movement Disorder Society
6.3: Writable Cholesteric Liquid Crystal Display and the Algorithm Used to Detect its Image (2007)

Abstract Writable Cholesteric Liquid Crystal Display and the algorithm used to detect its image were developed. We could use any hard tip, ex: the tip of a forefinger, to directly write an image on the surface of Cholesteric Liquid Crystal Display (CHLCD). By measuring the capacitance of one pixel of test cell (12mm × 15mm/ 1×1), F‐state or P‐state could be detected. By measuring the capacitance of one pixel of 4.1″ CHLCD (241um × 241um/ 320×320), F‐state or P‐state could not be detected, due to the effect of parasitic capacitance. Therefore, high frequency measurement and the algorithm were developed to detect the image on CHLCD.
An integrated testbed for Virtual Ad Hoc Networks (2009)

Testing of applications for ad hoc networks poses a special technical challenge due to the difficulty of conducting experiments in an ad hoc network environment at a scale larger than a few nodes. One approach is to conduct experiments in a testbed that can imitate an ad hoc network. This requires the development of technologies that enable multiple instances of unmodified application software on a set of hosts to communicate via a simulated network that behaves like a real ad hoc network. In this paper, we describe the testbed developed under the virtual ad hoc network (VAN) project for testing applications over ad hoc networks, with a special focus on network management applications. The testbed employs Xen-based virtualization to achieve resource scalability. The infrastructure for the testbed provides an integrated platform consisting of virtual nodes running the actual software under test, augmented with a simulated network environment. Our goal is to enable software testing over large-scale (500-1000 nodes) ad hoc networks using the VAN testbed.
Synthetic Modification within the “RPRL” Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation (2017)

Apelin is an important mammalian peptide hormone with a range of physiological roles, especially in the cardiovascular system. The apelinergic system is a promising target for treatment of disease, but this remains to be realized due to rapid proteolysis of apelin-derived peptides by proteases, including neprilysin (NEP). The synthetic analogues modified within the NEP degradation site ("RPRL" motif) showed improved in vitro proteolytic stability while maintaining receptor-binding affinities, with three candidate peptides retaining full cardiovascular activities for potential therapeutic application. Many such analogues proved physiologically inactive even with relatively conservative modifications, highlighting the importance of this region for full agonist activity of this peptide hormone.
Enhancement-mode AlGaN/GaN HEMTs on silicon substrate (2006)

High-performance enhancement-mode AlGaN/GaN HEMTs (E-HEMTs) were demonstrated with samples grown on a low-cost silicon substrate for the first time. The fabrication process is based on a fluoride-based plasma treatment of the gate region and postgate annealing at 450 /spl deg/C. The fabricated E-HEMTs have nearly the same peak transconductance (G/sub m/) and cutoff frequencies as the conventional depletion-mode HEMTs fabricated on the same wafer, suggesting little mobility degradation caused by the plasma treatment.
Restoration Design with Selective Optical Bypass in IP-over-Optical Networks (2012)

We propose a multi-layer restoration scheme that strategically selects a subset of IP links to be restored at the optical layer with the rest being restored at the IP layer, resulting in significant cost savings.
Low motional resistance ring-shaped contour-mode aluminum nitride piezoelectric micromeckanical resonators for UHF applications (2005)

This paper reports experimental results on a new class of ring-shaped, contour-mode aluminum nitride piezoelectric resonators that span a frequency range from 223 MHz to 656 MHz showing high quality factors in air (Q/sub max/=2,900 at 472.7 MHz), low motional resistance (ranging from 56 to 205 /spl Omega/), and center frequencies that can be lithographically tuned. These resonators achieve the lowest value of motional resistance ever reported for contour-mode resonators and combine it with high Q factors, therefore truly enabling the fabrication of arrays of microresonators with different frequencies on a single chip. Uncompensated temperature coefficients of frequency of only approximately -25 ppm//spl deg/C were also recorded for these resonators.
Beyond Shared Hierarchies: Deep Multitask Learning through Soft Layer\n Ordering (2017)

Existing deep multitask learning (MTL) approaches align layers shared between\ntasks in a parallel ordering. Such an organization significantly constricts the\ntypes of shared structure that can be learned. The necessity of parallel\nordering for deep MTL is first tested by comparing it with permuted ordering of\nshared layers. The results indicate that a flexible ordering can enable more\neffective sharing, thus motivating the development of a soft ordering approach,\nwhich learns how shared layers are applied in different ways for different\ntasks. Deep MTL with soft ordering outperforms parallel ordering methods across\na series of domains. These results suggest that the power of deep MTL comes\nfrom learning highly general building blocks that can be assembled to meet the\ndemands of each task.\n
Directional Full-Duplex RF Booster for 2450 MHz ISM Band (2016)

A directional repeater system with simple architecture composed of wideband receive and transmit antennas, a high gain low-power amplifier, and a bandpass filter is proposed for the 2450-MHz ISM band. The repeater system does not require down-conversion and up-conversion with frequency translation and does not rely on any operational protocol to manage users. As a result, the repeater (RF booster) can support all users, channels, modulation themes, and devices simultaneously. Close to 70 dB of isolation between the Tx and Rx antennas over the entire band (~100 MHz) is achieved for a compact structure with lateral dimensions of 8 cm × 12 cm and thickness of 1 cm. The isolation between the Tx and Rx antennas is achieved using polarization mismatch between orthogonal double-stack patch antennas and a novel two-element Rx antenna whose elements are appropriately located with respect to the Tx antenna to cancel the signal leakage from the Tx antenna to the Rx antennas. Two types of repeaters, one utilizing only the ground plane and polarization mismatch, and the second using the two-element Rx antenna in addition to polarization mismatch, are fabricated and tested in different environments. It is shown that more than 30 dB improvement in coverage can be achieved.
O2‐05‐08: The MimoVax vaccine: A novel Alzheimer treatment strategy targeting truncated Aß40/42 by active immunization (2009)

AD is characterised by the abnormal accumulation of amyloid plaques - closely associated with extensive astrocytosis and microgliosis as well as dystrophic neurones and neuronal loss. In humans most of the amyloid plaque material is formed by N-terminally truncated and modified Aβ derivatives. These truncated Aβ species are correlated with increasing severity and early onset of neurodegeneration in AD patients. Most importantly, recent results obtained from autopsy cases analysing patients which underwent AN1792 vaccination showed a clearance of full length Aß species but a persistence of N-terminally truncated forms of Aß. This underscores the necessity for the development of novel vaccines targeting various forms of Aß. Thus the MimoVax vaccine has been developed to target truncated and modified forms of Aß. Additionally, the AFFITOPE based MimoVax vaccine will also provide means to target oligomers of Aβ which are thought to be a major cause of the synaptic alterations and cognitive malfunctions typical of AD. MimoVax vaccines have been used to immunise mice overexpressing human APP (hAPP). Subsequently, amyloid burden, alterations of AD-like pathology and cognitive functions were analysed in these animals after repeated vaccination. MimoVax vaccination experiments in hAPP mice lead to significant reduction of amyloid plaque load and associated pathological alterations in the brain. Additionally, no Aβ specific T-cells are detectable in treated animals. Thus our data suggest that the AFFITOPE vaccines targeting truncated and modified forms of Aß could provide a novel AD treatment strategy with improved safety and efficacy features for use in AD patients.
A mathematical model of parathyroid gland biology (2019)

Altered parathyroid gland biology in patients with chronic kidney disease (CKD) is a major contributor to chronic kidney disease-mineral bone disorder (CKD-MBD). This disorder is associated with an increased risk of bone disorders, vascular calcification, and cardiovascular events. Parathyroid hormone (PTH) secretion is primarily regulated by the ionized calcium concentration as well as the phosphate concentration in the extracellular fluid and vitamin D. The metabolic disturbances in patients with CKD lead to alterations in the parathyroid gland biology. A hallmark of CKD is secondary hyperparathyroidism, characterized by an increased production and release of PTH, reduced expression of calcium-sensing and vitamin D receptors on the surface of parathyroid cells, and hyperplasia and hypertrophy of these cells. These alterations happen on different timescales and influence each other, thereby triggering a cascade of negative and positive feedback loops in a highly complex manner. Due to this complexity, mathematical models are a useful tool to break down the patterns of the multidimensional cascade of processes enabling the detailed study of subsystems. Here, we introduce a comprehensive mathematical model that includes the major adaptive mechanisms governing the production, secretion, and degradation of PTH in patients with CKD on hemodialysis. Combined with models for medications targeting the parathyroid gland, it provides a ready-to-use tool to explore treatment strategies. While the model is of particular interest for use in hemodialysis patients with secondary hyperparathyroidism, it has the potential to be applicable to other clinical scenarios such as primary hyperparathyroidism or hypo- and hypercalcemia.
Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV (2017)

Activity and selectivity assessment of new bi-aryl amide 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors, prepared in a modular manner via Suzuki cross-coupling, are described. Several compounds inhibiting 11β-HSD1 at nanomolar concentrations were identified. Compounds 2b, 3e, 7b and 12e were shown to selectively inhibit 11β-HSD1 over 11β-HSD2, 17β-HSD1 and 17β-HSD2. These inhibitors also potently inhibited 11β-HSD1 activity in intact HEK-293 cells expressing the recombinant enzyme and in intact primary human keratinocytes expressing endogenous 11β-HSD1. Moreover, compounds 2b, 3e and 12e were tested for their activity in human skin biopsies. They were able to prevent, at least in part, both the cortisone- and the UV-mediated decreases in collagen content. Thus, inhibition of 11β-HSD1 by these compounds can be further investigated to delay or prevent UV-mediated skin damage and skin aging.
An integrated microfluidic system for affinity extraction and concentration of biomolecules coupled to MALDI-MS (2008)

We present an innovative microfluidic device that accomplishes integrated, all-aqueous realization of specific extraction, concentration, and coupling to mass spectrometric detection of biomolecular analytes. The device uses an aptamer (i.e., oligonucleotide that binds specifically to an analyte via affinity coupling) immobilized on microbeads to achieve highly selective analyte capture and concentration. Here, we demonstrate specific extraction and concentration of adenosine monophosphate (model analyte) by approximately 100x, while providing a reusable platform via sufficiently low temperature release and regeneration of the aptamer surface at 38 degC.
Evaluation of a Cytolethal Distending Toxin (<i>cdt</i>) Gene-Based Species-Specific Multiplex PCR Assay for the Identification of <i>Campylobacter</i> Strains Isolated from Diarrheal Patients in Japan (2011)

We have developed a cytolethal distending toxin (cdt) gene-based species-specific multiplex PCR assay for the detection and identification of Campylobacter jejuni, C. coli, and C. fetus. The applicability of this assay was evaluated with 325 Campylobacter strains isolated from diarrheal patients in Japan and the results were compared with those obtained by other genetic methods, including hipO gene detection and 16S rRNA gene sequencing. Of the 325 strains analyzed, 314 and 11 were identified as C. jejuni and C. coli, respectively, by combination of hipO gene detection and 16S rRNA gene sequencing. When the multiplex PCR assay was employed, 309, 310, and 314 strains were identified as C. jejuni on the basis of cdtA, cdtB, and cdtC gene-specific primers, respectively. Similarly, 11, 11, and 10 strains were identified as C. coli on the basis of cdtA, cdtB, and cdtC gene-specific primers, respectively. Sequence analysis of the cdt gene region of 6 strains (5 C. jejuni and 1 C. coli) which did not yield specific PCR products in any of the cdt gene-based multiplex PCR assays revealed deletions or mutations of the cdt genes. Pulsed-field gel electrophoresis indicated that C. jejuni and C. coli strains were genetically diverse. Taken together, these findings suggest that the cdtC gene-based multiplex PCR seems to be a particularly simple and rapid method for differentiating between species of Campylobacter strains, such as C. jejuni and C. coli. However, combination of these multiplex PCR assays will allow more accurate identification.