gebhart/patrepeval huggingface dataset:
Oscillatory Flow and Gas Transport Through a Symmetrical Bifurcation (2000)

Axial gas transport due to the interaction between radial mixing and radially nonuniform axial velocities is responsible for gas transport in thick airways during High-frequency oscillatory ventilation (HFO). Because the airways can be characterized by a bifurcating tube network, the secondary flow in the curved portion of a bifurcating tube contributes to cross-stream mixing. In this study the oscillatory flow and concentration fields through a single symmetrical airway bifurcating tube model were numerically analyzed by solving three-dimensional Navier-Stokes and mass concentration equations with the SIMPLER algorithm. The simulation conditions were for a Womersley number, alpha = 9.1 and Reynolds numbers in the parent tube between 200 and 1000, corresponding to Dn2/alpha 4 in the curved portion between 2 and 80, where Dn is Dean number. For comparison with the results from the bifurcating tube, we calculated the velocity and concentration fields for fully developed oscillatory flow through a curved tube with a curvature rate of 1/10, which is identical to the curved portion of the bifurcating tube. For Dn2/alpha 4 < or = 10 in the curved portion of the bifurcating tube, the flow divider and area changes dominate the axial gas transport, because the effective diffusivity is greater than in either a straight or curved tube, in spite of low secondary velocities. However, for Dn2/alpha 4 > or = 20, the gas transport characteristics in a bifurcation are similar to a curved tube because of the significant effect of secondary flow.
VMCloner: A Fast and Flexible Virtual Machine Cloner (2013)

VMCloner robustly clones a VM into multiple copies which are thereafter placed on different hosts. Avoiding the downtime incurred in installing the operating system for preparing the cloned VM to complete a specified task, the clones share the same initial state. The major focus in the creation of VMCloner has been on the demanding scenarios of services requiring large computations, fixing the problems of admission control, load handling, parallel computing, and efficient job placement. After cloning, each cloned virtual machine can evolve independently, providing similar semantics and configuration setup. This abstraction is useful for supporting cloud server farms with rapid VM deployment. VMCloner provides cloning of virtual machines with large virtual disks in a matter of seconds, fixes the issue of scalability by deploying thousands of VMs, and finally maximizes resource utilization.
Formulation and Evaluation of Celastrol-Loaded Liposomes (2011)

The main purpose of this study was to evaluate the intestinal absorption and the antineoplastic effect of the poorly water-soluble drug celastrol when liposomes were used as oral drug delivery system. Liposomes were prepared by the ethanol-injection method. An optimized liposome formulation composed of phospholipid, cholesterol and Tween-80 resulted in favorable encapsulation efficiency at 98.06 ± 0.94%. Homogeneous and stable particle size of 89.6 ± 7.3 nm and zeta potential of -(87.7 ± 5.8) mV were determined by laser particle size analyzer. Subsequently, the four-site perfusion rat intestinal model revealed that celastrol-loaded liposomes had improved effective permeability compared to the free drug in four intestinal segments (p < 0.05). Moreover, celastrol-loaded liposomes could also inhibit the tumor growth in C57BL/6 mice. These results suggest that liposomes could be a promising perioral carrier for celastrol.
Molecular Typing of Legionella pneumophila Isolates in the Province of Quebec from 2005 to 2015 (2016)

Legionella is found in natural and man-made aquatic environments, such as cooling towers and hot water plumbing infrastructures. Legionella pneumophila serogroup 1 (Lp1) is the most common etiological agent causing waterborne disease in the United States and Canada. This study reports the molecular characterization of Lp strains during a 10 year period. We conducted sequence-based typing (SBT) analysis on a large set of Lp isolates (n = 284) to investigate the province of Quebec sequence types (STs) distribution in order to identify dominant clusters. From 2005 to 2015, 181 clinical Lp isolates were typed by SBT (141 sporadic cases and 40 outbreak related cases). From the same period of time, 103 environmental isolates were also typed. Amongst the 108 sporadic cases of Lp1 typed, ST-62 was the most frequent (16.6%), followed by ST-213 (10.2%), ST-1 (8.3%) and ST-37 (8.3%). Amongst other serogroups (SG), ST-1327 (SG5) (27.3%) and ST-378 (SG10) (12.2%) were the most frequent. From the environmental isolates, ST-1 represent the more frequent SBT type (26.5%). Unweighted pair group method with arithmetic mean (UPGMA) dendrogram from the 108 sporadic cases of SG1 contains 4 major clusters (A to D) of related STs. Cluster B contains the majority of the strains (n = 61) and the three most frequent STs in our database (ST-62, ST-213 and ST-1). During the study period, we observed an important increase in the incidence rate in Quebec. All the community associated outbreaks, potentially or confirmed to be associated with a cooling tower were caused by Lp1 strains, by opposition to hospital associated outbreaks that were caused by serogroups of Lp other than SG1. The recent major Quebec City outbreak caused by ST-62, and the fact that this genotype is the most common in the province supports whole genome sequencing characterization of this particular sequence type in order to understand its evolution and associated virulence factors.
Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET (2014)

GSK1144814 is a potent, insurmountable antagonist at human NK₁ and NK₃ receptors. Understanding the relationship between plasma pharmacokinetics and receptor occupancy in the human brain, was crucial for dose selection in future clinical studies. GSK1144814 occupancy data were acquired in parallel with the first-time-in-human safety and tolerability study. [¹¹C]GR-205171 a selective NK₁ receptor PET ligand was used to estimate NK₁ occupancy at several time-points following single dose administration of GSK1144814. The time-plasma concentration-occupancy relationship post-single dose administration was assessed, and used to predict the plasma concentration-occupancy relationship following repeat dose administration. Repeat dose predictions were tested in a subsequent cohort of subjects examined following approximately 7 and 14 days dosing with GSK1144814. GSK1144814 was shown to demonstrate a dose-dependent occupancy of the NK₁ receptor with an estimated in vivo EC₅₀~0.9 ng/mL in the human brain. A direct relationship was seen between the GSK1144814 plasma concentration and its occupancy of the brain NK₁ receptor, indicating that in future clinical trials the occupancy of brain receptors can be accurately inferred from the measured plasma concentration. Our data provided support for the further progression of this compound and have optimised the likely therapeutic dose range.
Higher Radix Squaring Operations Employing Left-to-Right Dual Recoding (2009)

We introduce a novel left-to-right leading digit first dual recoding of an operand for the purpose of designing the squaring operation on that operand. Our dual recoding yields an array of non-negative partial squares of size essentially one half that of a comparable multiplier partial product array for both radix-4 and radix-8 designs. For radix-8 design the 128-bit square of a 64-bit operand can be obtained from a consolidated partial square array of just 11 rows. We describe advantages of our left-to-right recoding compared to a previous right-to-left Booth-folding encoding applicable to radix-4. We also show simplifications available to the designs of a rounded floating point square operation and to a low precision approximate square.
Clustering Analysis of Student Learning Outcomes Based on Education Data (2019)

This Research to Practice Full Paper extracts knowledge from the education data through clustering student outcomes for application towards refining course design. Changes in the field of technology and other aspects of the work environment calls for continual advancement in the education sector. Analysis of the outcomes of students from the Senior Exit Survey gauges the competence of graduates in their field of study. This survey is routinely conducted on students close to finishing an undergraduate degree and contains information about the various experiences while learning at Cal Poly Pomona. Understanding of these outcomes allows the faculty and the administration to improve the courses in an effective manner. The basis of this study is to cluster student learning outcomes and distinguish those with superior similarity. These outcomes can be fused for a targeted approach towards designing optimized courses. The clusters were developed using one of the most frequently used unsupervised learning techniques, or, the hierarchical clustering algorithm through R statistical analysis software. This algorithm had been proven to be reliable yet easy to interpret in past literature. For the purposes of this study, the hierarchical clustering model is defined by the dissimilarity measure between each pair of observation using the Euclidean distance along with the use of both complete and average linkages. The results from the two linkages were displayed using dendrograms. For additional visualization and verification of the clusters, a heat map was also constructed to illustrate the results using the complete linkage. A comparison of the results from these two linkages demonstrates exceptional similarities amongst the clusters; all but one outcome did not fall within the same clusters. In conclusion, the results show there exist three major clusters and three pairs of closely related outcomes to form out of the Senior Exit Survey data.
Sulfobutyl Ether β-Cyclodextrin (SBE-β-CD) in Eyedrops Improves the Tolerability of a Topically Applied Pilocarpine Prodrug in Rabbits (1995)

The effects of a novel, modified beta-cyclodextrin (SBE4-beta-CD; a variably substituted sulfobutyl ether with an average degree of substitution of four) on eye irritation and miotic response of an ophthalmically applied pilocarpine prodrug, O,O'-dipropionyl-(1,4-xylylene) bispilocarpate, in albino rabbits were studied. Compared to the commercial pilocarpine eyedrop solution (163 mM, equivalent to 3.4% pilocarpine), 12-24 mM pilocarpine prodrug solutions (equivalent to 0.5-1.0% pilocarpine, respectively) decreased peak miotic intensity (Imax) and increased the time to reach peak (tmax), but did not significantly affect values for the area under the miosis versus time curves (AUC), i.e. 12-24 mM pilocarpine prodrug appeared to be equivalent to 163 mM pilocarpine. Ocularly applied 12-24 mM pilocarpine prodrug solutions, however, were more irritating than a commercial pilocarpine eyedrop solution. Coadministered SBE4-beta-CD significantly decreased the eye irritation of the pilocarpine prodrug solutions. Coadministered SBE4-beta-CD did not affect the miotic response of prodrug solution when the molar ratio of SBE4-beta-CD to prodrug was low. However, increasing the molar ratio of SBE4-beta-CD to prodrug decreased the Imax and AUC values. The results show that eye irritation of the pilocarpine prodrug is prevented by levels of SBE4-beta-CD that do not affect the apparent ocular absorption of the prodrug.
Ankle: Isotropic MR Imaging with 3D-FSE-Cube—Initial Experience in Healthy Volunteers (2008)

The purpose of this prospective study was to compare a new isotropic three-dimensional (3D) fast spin-echo (FSE) pulse sequence with parallel imaging and extended echo train acquisition (3D-FSE-Cube) with a conventional two-dimensional (2D) FSE sequence for magnetic resonance (MR) imaging of the ankle. After institutional review board approval and informed consent were obtained and in accordance with HIPAA privacy guidelines, MR imaging was performed in the ankles of 10 healthy volunteers (four men, six women; age range, 25-41 years). Imaging with the 3D-FSE-Cube sequence was performed at 3.0 T by using both one-dimensional- and 2D-accelerated autocalibrated parallel imaging to decrease imaging time. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) with 3D-FSE-Cube were compared with those of the standard 2D FSE sequence. Cartilage, muscle, and fluid SNRs were significantly higher with the 3D-FSE-Cube sequence (P < .01 for all). Fluid-cartilage CNR was similar for both techniques. The two sequences were also compared for overall image quality, blurring, and artifacts. No significant difference for overall image quality and artifacts was demonstrated between the 2D FSE and 3D-FSE-Cube sequences, although the section thickness in 3D-FSE-Cube imaging was much thinner (0.6 mm). However, blurring was significantly greater on the 3D-FSE-Cube images (P < .04). The 3D-FSE-Cube sequence with isotropic resolution is a promising new MR imaging sequence for viewing complex joint anatomy.
Blockchain Technology for Healthcare: Facilitating the Transition to Patient-Driven Interoperability (2018)

Interoperability in healthcare has traditionally been focused around data exchange between business entities, for example, different hospital systems. However, there has been a recent push towards patient-driven interoperability, in which health data exchange is patient-mediated and patient-driven. Patient-centered interoperability, however, brings with it new challenges and requirements around security and privacy, technology, incentives, and governance that must be addressed for this type of data sharing to succeed at scale. In this paper, we look at how blockchain technology might facilitate this transition through five mechanisms: (1) digital access rules, (2) data aggregation, (3) data liquidity, (4) patient identity, and (5) data immutability. We then look at barriers to blockchain-enabled patient-driven interoperability, specifically clinical data transaction volume, privacy and security, patient engagement, and incentives. We conclude by noting that while patient-driving interoperability is an exciting trend in healthcare, given these challenges, it remains to be seen whether blockchain can facilitate the transition from institution-centric to patient-centric data sharing.
Angiotensin converting enzyme 2 and angiotensin (1–7) axis in pulmonary arterial hypertension (2020)

The AngII-ACE2-Ang(1-7) axis appears to be altered in human PAH and we propose that this imbalance, in favour of AngII, plays a role in the pathogenesis of the severe PAH. Further mechanistic studies are warranted.
La enfermedad de las vacas locas; análisis de los fenómenos científicos y mediáticos (1996)

Recientemente hemos sido victimas de un sindrome de histeria colectiva sobre el caso de las «vacas locas». Montserrat Daban y Mariona Grau analizan diversos aspectos de esta alarma social desde el ambito cientifico al politico, pasando por datos epidemiologicos. Todos tenemos alguna referencia sobre este fenomeno mediatico y sanitario, que ha pasado del ambito cientifico a las tertulias populares. Pero ?esta justificada la bomba informativa?, ? son solo las vacas las que se han vuelto locas?
Focal plane imaging systems for millimeter wavelengths (1993)

The authors discuss critical aspects of imaging system design and describe several different imaging systems employing focal plane array receivers operating in the 3-mm-2-mm wavelength range. Recent progress in millimeter-wavelength optics, antennas, receivers and other components permits greatly enhanced system performance in a wide range of applications. A radiometric camera for all-weather autonomous aircraft landing capability and a high sensitivity cryogenically cooled array for use in radio astronomical spectroscopy are presented. A near-focus system for identification of plastic materials concealed underneath clothing employs a two element lens, and has been demonstrated in active (transmitting) and passive (radiometric) modes. A dual-mode imaging system for plasma diagnostics utilizes both active and passive modes at its approximately=140-GHz operating frequency to study small-scale structure. The radiometric imaging systems employ between 15 and 256 Schottky barrier diode mixers, while the imaging receivers for the active systems include 64-element video detector arrays.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Metal exchange reactions between cadmium protoporphyrin and cobalt and zinc chlorides in acetonitrile and dimethyl sulfoxide (2006)

Metal exchange between cadmium protoporphyrin CdPP and zinc and cobalt chlorides in dimethyl sulfoxide (DMSO) and acetonitrile (AN) was studied by spectrophotometry. Comparative analysis of the data on metal exchange between CdPP and ZnCl2 in DMSO and between CdPP and CoCl2 in AN was performed. The possible exchange mechanisms were considered. The results were compared with the data on cadmium mesoporphyrin exchange with zinc and cobalt.
Odd−Even Effects and the Influence of Length and Specific Positioning of Alkoxy Side Chains on the Optical Properties of PPE−PPV Polymers (2005)

This contribution reports the combined influences of odd−even effects and the specific positioning of alkoxy side chains OR1 = (OCn+10H2(n+10)+1) and OR2 = (OCnH2n+1) (with n = 6, 7, 8, 9) on the phenylene−ethynylene and phenylene−vinylene segments, respectively, on the optical properties of hybrid polymers P(n+10)/n of general repeating unit: −Ph−C⋮C−Ph−C⋮C−Ph−CHCH−Ph−CHCH−. For the polymeric materials, visual color impression varies alternatively between orange red (P16/6 and P18/8) and yellow (P17/7 and P19/9) according to the odd and even features of the alkoxy side chains, where odd or even relates to the total number of sp3-hybridized atoms within the side chains. This side chain related effect is ascribed to both absorptive and emissive behaviors of the polymers on the basis of photophysical investigations in the bulk. Almost identical thin film absorption spectra were obtained for all four materials; however, the photoluminescence of the odd polymers, P16/6 (λf = 556 nm) and P18/8 (λf = 614 nm), was red-shifted relative to that of their even counterparts (λf = 535 nm). Further, the P18/8 maximum at 614 nm can be readily assigned to excimer emission, as evidenced by the largest Stokes shift (5600 cm-1), largest fwhmf-value (3700 cm-1), and the lowest Φf-value of 24%. The strong π−π interchain interaction in P18/8, due to loose alkoxy side chains packing, does not only favor fluorescence quenching but also enable an effective inter- as well as intra-molecular recombination of the generated positive and negative polarons in electroluminescence, which explains the good EL properties of this polymer irrespective of the solvent used. A voltage-dependent blue shift of the EL spectra of up to 100 nm was observed for P18/8 devices prepared from aromatic solvents. This red to green EL shift as observed with increasing voltage is assigned to conformational changes of the polymer chains with increasing temperature.
Computation and the immune system (1992)

article Computation and the immune system Share on Authors: Stephanie Forrest View Profile , Alan S. Perelson View Profile Authors Info & Claims ACM SIGBIO NewsletterVolume 12Issue 2June 1992 pp 52–57https://doi.org/10.1145/130686.130696Online:01 June 1992Publication History 2citation129DownloadsMetricsTotal Citations2Total Downloads129Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Digital-image analysis to predict weight and yields of boneless subprimal beef cuts (2003)

For several decades, beef carcass evaluation for grading or research purposes has relied upon subjective visual scores, and manually taken measurements, but in recent times there has been a growing interest in new technologies capable of improving accuracy of estimates. Equations to predict weight and yield of beef pistol subprimal cuts were developed in this work using digital image analysis (VIA) of the 12th rib steak. Equations to predict total pistol subprimal cuts weight (CUTS) had coefficients of determination (CD) of 0.84, or 0.87 to 0.88, when the independent variables were the VIA parameters and the half carcass weight (HC) or the total pistol weight (TP), respectively. The predicted values for the total seven subprimal cuts, as a percentage of half carcass weight (CUTS%), presented CD values ranging from 0.37 to 0.47, or 0.21 to 0.31, using HC or TP as a principal independent variable. Likewise, the equation for weight of the individual subprimal cuts had CD values ranging from 0.40 to 0.72, or 0.43 to 0.74 using HC or TP, respectively. In this research, the developed VIA procedure has demonstrated good repeatability and accuracy to estimate the total pistol subprimal weights, and some individual subprimal weights.
Application of a Proapoptotic Peptide to Intratumorally Spreading Cancer Therapy (2012)

Bit1 is a proapoptotic mitochondrial protein associated with anoikis. Upon cell detachment, Bit1 is released into the cytoplasm and triggers caspase-independent cell death. Bit1 consists of 179 amino acids; for the C-terminal, two thirds of the molecule functions as a peptidyl-tRNA hydrolase, whereas the N-terminus contains a mitochondrial localization signal. Here, we localize the cell death domain (CDD) to the N-terminal 62 amino acids of Bit1 by transfecting cells with truncated Bit1 cDNA constructs. CDD was more potent in killing cells than the full-length Bit1 protein when equivalent amounts of cDNA were transfected. To develop Bit1 CDD into a cancer therapeutic, we engineered a recombinant protein consisting of the CDD fused to iRGD, which is a tumor-specific peptide with unique tumor-penetrating and cell-internalizing properties. iRGD-CDD internalized into cultured tumor cells through a neuropilin-1-activated pathway and triggered cell death. Importantly, iRGD-CDD spread extensively within the tumor when injected intratumorally into orthotopically implanted breast tumors in mice. Repeated treatment with iRGD-CDD strongly inhibited tumor growth, resulting in an average reduction of 77% in tumor volume and eradication of some tumors. The caspase independence of Bit1-induced cell death makes CDD a potentially attractive anticancer agent, because tumor resistance to the main mechanisms of apoptosis is circumvented. Using iRGD to facilitate the spreading of a therapeutic agent throughout the tumor mass may be a useful adjunct to local therapy for tumors that are surgically inoperable or difficult to treat systemically.