gebhart/patrepeval huggingface dataset:
Impact of a lactobacilli-containing gel on vulvovaginal candidosis and the vaginal microbiome (2020)

Vulvovaginal candidosis (VVC) is a common condition with severe symptoms and high recurrence rates. Probiotic lactobacilli are explored as alternatives to azole treatments. Although the vaginal microbiota is generally not depleted in lactobacilli during VVC, studies indicate that the functionality and antimicrobial activity of the lactobacilli is impaired. We selected three strains from the Lactobacillus genus complex (L. rhamnosus GG, L. pentosus KCA1 and L. plantarum WCFS1) based on in vitro evaluation and formulated them in a gel for vaginal application. This gel was evaluated in 20 patients suffering from acute VVC, who were followed for four weeks including a 10-day treatment period. The microbiome was assessed through 16S rRNA (bacteria) and internal transcribed spacer (ITS; fungi) amplicon sequencing, supplemented with quantitative PCR, culture and microscopy for Candida evaluation. 45% of women did not require rescue medication (3×200 mg fluconazole), implying an improvement of their symptoms. These women showed similar end concentrations of fungi as women treated with fluconazole. Moreover, fluconazole appeared to reduce numbers of endogenous lactobacilli. Our study points towards important aspects for future selection of lactobacilli for probiotic use in VVC and the need to investigate possible negative influences of azoles on the vaginal bacterial community.
Bridging the gap between embedded test and ATE (2002)

This paper presents a methodology and software system architecture that enable conventional test equipment to take full advantage of embedded test structures implemented within the device under test. The proposed methodology provides a seamless transfer of embedded test related information from the design engineering to the manufacturing test environment, allowing for automated control of the embedded test for production go/no-go testing as well as advanced failure diagnosis.
Threshold Logical Clocks for Asynchronous Distributed Coordination and Consensus (2019)

Consensus protocols for asynchronous networks are usually complex and inefficient, leading practical systems to rely on synchronous protocols. This paper attempts to simplify asynchronous consensus by building atop a novel threshold logical clock abstraction, which enables upper layers to operate as if on a synchronous network. This approach yields an asynchronous consensus protocol for fail-stop nodes that may be simpler and more robust than Paxos and its leader-based variants, requiring no common coins and achieving consensus in a constant expected number of rounds. The same approach can be strengthened against Byzantine failures by building on well-established techniques such as tamper-evident logging and gossip, accountable state machines, threshold signatures and witness cosigning, and verifiable secret sharing. This combination of existing abstractions and threshold logical clocks yields a modular, cleanly-layered approach to building practical and efficient Byzantine consensus, distributed key generation, time, timestamping, and randomness beacons, and other critical services.
Amorphous Si/SiC three-color detector with adjustable threshold (1995)

An adjustable threshold color detector (ATCD) is demonstrated, based on a hydrogenated amorphous silicon (a-Si:H) and silicon–carbide (a-SiC:H) p+-i-n+-i-n+-i-p+ multilayer. The ATCD is able to discriminate between blue (λ=450 nm), green (550 nm), and red (≳650 nm) illumination by varying the externally applied voltage within a few volts. The operation of the detector can be explained regarding the ATCD as three independent devices connected in series: a p+-i-n+, a n+-i-n+, and a n+-i-p+. The novel feature is the n+-i-n+ cell. It acts as a short circuit under strong illumination, whereas in dark it is equivalent to two low quality back-to-back diodes which introduce a shift in the threshold in the photocurrent detection. Thanks to the large number of physical parameters such as layer thickness and band gap the ATCD appears extremely versatile.
Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis (2016)

The purpose of this study was to induce experimental periodontitis in rats previously fed diets containing arginine silicate inositol (ASI) complex and examine the biochemical, immunological, and radiological effects. Fifty two 8-week-old female Sprague Dawley rats were equally divided into four groups. The control group included those fed a standard rat diet with no operation performed during the experiment. The periodontitis, ASI I, and ASI II groups were subjected to experimental periodontitis induction for 11 days after being fed a standard rat diet alone, a diet containing 1.81 g/kg ASI complex, or a diet containing 3.62 g/kg ASI complex, respectively, for 8 weeks. Throughout the 11-day duration of periodontitis induction, all rats were fed standard feed. The rats were euthanized on the eleventh day, and their tissue and blood samples were collected. In the periodontitis group, elevated tissue destruction parameters and reduced tissue formation parameters were found, as compared to the ASI groups. Levels of enzymes, cytokines, and mediators associated with periodontal tissue destruction were lower in rats fed a diet containing ASI complex after experimental periodontitis. These results indicate that ASI complex could be an alternative agent for host modulation.
Pure-inertial AHRS with adaptive elimination of non-gravitational vehicle acceleration (2018)

Among the critical features of the Attitude and Heading Reference System (AHRS) is its ability to deal with an external, non-gravitational vehicle acceleration. When present, vehicle's acceleration becomes an inherent part of the accelerometer measurements, hindering them from being used for the direct estimation of the attitude. Reliable mitigation of the non-gravitational acceleration is of high importance, especially in the class of pure inertial AHRS systems, where the attitude of the vehicle is determined solely by use of inertial and magnetic field measurements, without any global navigation satellite system (GNSS) aiding. In this paper the design and performance of a new and computationally efficient pure inertial AHRS, based on extended Kalman filter state estimator, is proposed and experimentally illustrated. The design is based on the explicit incorporation of non-gravitational acceleration into the filter process model and on the adaptive on-line tuning of model parameters, reflecting the actual dynamics of the vehicle. Compared to the state-of-the-art AHRS designs, the proposed AHRS processes all the measurements available, regardless of the actual dynamics of the vehicle. The proposed AHRS is, therefore, suitable for modern high-integrity complex navigation solutions, particularly as a stand-alone back-up solution in GNSS-denied environments.
Photopolymer resins for luminescent three‐dimensional printing (2017)

ABSTRACT Liquid resins‐based three‐dimensional (3D) printing techniques such as stereolithography and digital light processing (DLP) show higher resolution and accuracy than other printing techniques, but their applications have been impeded by the limited materials selection and lack of functions. We here reported the preparation of luminescent resins for DLP‐based 3D printing. Homogeneous dispersion of the fluorescent dyes was achieved by small acrylate molecules screening, and the cure depth studies was used to optimize both resin composition and printing parameters setting. In addition, we showed that the optical analysis of absorption and emission spectra is an important tool to reduce the complex mutual‐interference of the light absorption of dye, photoinitiator and photo‐absorber in the printable resin. We also developed the mater batch technique to tune the emitting colors in the whole visible range, together with white emitting. By using the developed resins, different 3D structures with different emitting colors were successfully printed by DLP technique. These results will further widen the applications of the liquid resins‐based 3D printing techniques, and these luminescent resins show highly potential applications in education, lighting, UV converters, and so on. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44988.
Test-Architecture Optimization and Test Scheduling for TSV-Based 3-D Stacked ICs (2011)

Through-silicon via (TSV)-based 3-D stacked ICs (SICs) are becoming increasingly important in the semiconductor industry. In this paper, we address test architecture optimization for 3-D stacked ICs implemented using TSVs. We consider two cases, namely 3-D SICs with die-level test architectures that are either fixed or still need to be designed. We next present mathematical programming techniques to derive optimal solutions for the architecture optimization problem for both cases. Experimental results for three handcrafted 3-D SICs comprising of various systems-on-a-chip (SoCs) from the ITC'02 SoC test benchmarks show that compared to the baseline method of sequentially testing all dies, the proposed solutions can achieve significant reduction in test length. This is achieved through optimal test schedules enabled by the test architecture. We also show that increasing the number of test pins typically provides a greater reduction in test length compared to an increase in the number of test TSVs. Furthermore, we show that shorter test lengths are generally achieved with the larger, more complex dies lower in the stack. This is because test data must pass through every die lower in a stack in order to reach its target die, and with the larger dies lower in the stack, more test bandwidth may be provided to these dies using fewer routing resources.
Author response: Overcoming mutation-based resistance to antiandrogens with rational drug design (2013)

Mutagenesis studies identified an androgen receptor mutation that converts enzalutamide-a drug recently approved for the treatment of advanced prostate cancer-into an androgen receptor agonist, and modeling studies informed the design of novel drugs that are effective against the mutant receptor.
A microbeam collimator for high resolution x-ray diffraction investigations with conventional diffractometers (2002)

A collimating system has been developed for condensing hard x rays, providing very thin, intense, and low divergent beams. The primary radiation is compressed down to the micrometer scale by multiple total reflections in the channel between two oblong and flexible metallic mirrors with exit aperture 4 mm×15 μm. The flexible mirrors permit variation of the channel profile and opening for the incoming radiation, adjusted for maximum transmitted x-ray intensities. The condenser, due to the high brilliance gain of the obtained beam compared to the uncompressed radiation going through a slit of the same size, can be operated even with conventional x-ray tubes, e.g., common x-ray diffractometers without the need for expensive high intensity synchrotron radiation sources, as demanded usually by the glass monocapillaries. A prototype, being mounted on a commercial theta–theta diffractometer, has been thoroughly tested for intensity gain, divergence, and spatial resolution and utilized for accurate structure determinations on very thin regions (only some tens of microns) of solid materials. This article gives an extensive description of the apparatus and presents the obtained results of some representative investigations.
Abstract 15182: Imaging iPSC-Derived Cardiomyocytes Engrafted in a Mouse Model of Myocardial Infarction Using Stably Expressed APEX2 (2017)

Background: Although studies have shown the promising results for in vivo cardiac transplantation of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) in animal experiments, nan...
The Applied Physical Sciences Marine Vibrator: An Overview (2018)

Summary General Dynamics Applied Physical Sciences Corporation (APS) has developed, patented, and fabricated marine vibrator technology to meet the specifications established by the Marine Vibrator Joint Industry Project. The APS Marine Vibrator Integrated Projector Node recently completed in-water shakedown testing and results are presented. Additionally, an overview of the marine vibrator technology is discussed, including the transducer operating principles, performance capabilities, specifications, and requirements. Stationary deep water performance characterization of the APS Marine Vibrator conducted in January 2018 will also be presented.
Computerized Analysis of the Likelihood of Malignancy in Solitary Pulmonary Nodules with Use of Artificial Neural Networks (2000)

The computerized scheme has the potential to improve the diagnostic accuracy of radiologists in the distinction of benign and malignant solitary pulmonary nodules.
Leakage efficient chip-level dual-Vdd assignment with time slack allocation for FPGA power reduction (2005)

To reduce power, Vdd programmability has been proposed recently to select Vdd-level for interconnects and to powergate unused interconnects. However, Vdd-level converters used in the Vdd-programmable method consume a large amount of leakage. In this paper, we develop chip-level dual-Vdd assignment algorithms to guarantee that no low-Vdd interconnect switch drives high-Vdd interconnect switches. This removes the need of Vdd-level converters and reduces interconnect leakage and interconnect device area by 91.78% and 25.48%, respectively. The assignment algorithms include power sensitivity based heuristics with implicit time slack allocation and a linear programming (LP) based method with explicit time slack allocation. Both first allocate time slack to interconnects with higher transition density and assign low-Vdd to them for more power reduction. Compared to the aforementioned Vdd-programmable method using Vdd-level converters, the LP based algorithm reduces interconnect power by 65.13% without performance loss for the MCNC benchmark circuits. Compared to the LP based algorithm, the sensitivity based heuristics can obtain slightly smaller power reduction but run 4X faster.
Influence of heat treatment on corrosion resistance of aluminum alloy brazing sheet (2007)

SWAAT for 20 days has been carried out on brazing sheets of 1 mm thickness to estimate outside corrosion resistance on the material for aluminum heat exchanger applied at higher temperature. Maximum corrosion depth after the test decreased in brazing sheets both of Al–1%Mn alloy core and of Al–1%Mn–0.5%Si alloy core clad with Al–Si alloy filler while it increased in that of Al–1%Mn–0.5%Si–0.5%Cu alloy core, with increase of heat treatment time at 200°C after brazing. Marked intergranular corrosion in the core was observed in the latter alloy. On the other hand, general corrosion was observed in brazing sheets clad with filler alloy containing Zn, and the attack stopped at near interface between filler and core, independent of core alloys and of heat treatment time. Corrosion characteristics and attack depth on the sheets were discussed in terms of electrochemical properties of filler and core alloys.
The <i>Saccharomyces CDC</i> <i>13</i> protein is a single-strand TG <sub>1–3</sub> telomeric DNA-binding protein <i>in vitro</i> that affects telomere behavior  <i>in vivo</i> (1996)

Saccharomyces telomeres consist of approximately 300 bp of C1-3A/TG1-3 DNA. Cells lacking the activity of the essential gene CDC13 display a cell cycle arrest mediated by the DNA damage sensing, RAD9 cell cycle checkpoint, presumably because they exhibit strand-specific loss of telomeric and telomere-adjacent DNA [Garvik, B., Carson, M. & Hartwell, L. (1995) Mol. Celi. Biol. 15,6128-6138]. Cdc13p expressed in Escherichia coli or overexpressed in yeast bound specifically to single-strand TG1-3 DNA. The specificity of binding displayed by Cdc13p in vitro indicates that in vivo it could bind to both the short, constitutive single-strand TG1-3 tails thought to be present at telomeres at most times in the cell cycle as well as to the long single-strand TG1-3 tails that are intermediates in telomere replication. Genes located near yeast telomeres are transcriptionally repressed, a phenomenon known as telomere position effect. Cells overexpressing a mutant form of Cdc13p had reduced telomere position effect at high temperatures. These data suggest that Cdc13p functions by binding directly to telomeric DNA, thereby limiting its accessibility to degradation and transcription as well as masking it from factors that detect damaged DNA.
Parallel transmission pulse design with explicit control for the specific absorption rate in the presence of radiofrequency errors (2015)

Our worst-case SAR-constrained pTx design strategy yields pulses with local and global SAR within the safety limits even in the presence of RF transmission errors. This strategy is a natural way to incorporate SAR safety factors in the design of pTx pulses. Magn Reson Med 75:2493-2504, 2016. © 2015 Wiley Periodicals, Inc.
ChemInform Abstract: Ruthenium‐Catalyzed trans‐Selective Hydrostannation of Alkynes. (2014)

Abstract The methodology is also applied to molecules bearing a terminal alkyne as well as an internal alkyne functionality showing moderate to high selectivity for hydrostannation of the terminal over the internal alkyne moiety depending on the substituents of the latter.
Control rod drive for reactor shutdown. [LMFBR] (1976)

A means is described for rapidly shutting down or scramming a nuclear reactor, such as a liquid metal-cooled fast breeder reactor. The system serves as a backup to the primary shutdown system. The control rod drive consists basically of an in-core assembly, a drive shaft and seal assembly, and a control drive mechanism. The control rod is driven into the core region of the reactor by gravity and hydraulic pressure forces supplied by the reactor coolant, thus assuring that common mode failures will not interfere with or prohibit scramming the reactor when necessary.
Quick, portable toxicity testing of marine or terrigenous fluids, sediments, or chemicals with bioluminescent organism (1995)

A hand-held, battery-operated instrument, which measures bioluminescence inhibition of the microscopic marine dinoflagellate Pyrocystis lunula, is capable of field-testing substances for toxicity. The organism is sensitive to ppb of strong toxicants. It tolerates some solvents in concentrations necessary for testing lipophylic samples. A test consumes only micrograms of sample. This method requires no adjustments for salinity, pH, color, or turbidity. It has been used successfully to test oil-well drilling fluids, brines produced with oil, waters and sediments from streams and lakes and petroleum-plant effluents containing contaminants such as benzene. The test is non-specific; however, if the substance is known, the end-point effects a direct measurement of its concentration. One-hour toxicity screening tests in the field produce results comparable to the standard four-hour laboratory test. Keeping the sample in the dark during incubation and testing, together with shortness of the overall procedure, eliminates anomalies from light-sensitive substances. Day-to-day variation, as well as among test replicates, is less than 10%. This quick method yields results comparable with a quick test that uses Photobacterium phosphoria, and with 96-hour tests that use Mysidopsis bahia, Artemia salina, Gonyaulax polyedra, Pimephales promelas, Ceriodaphnia dubia, and Cyprinodon variegatus.
Epitope Mapping of the Immunodominant Invariable Region of<i>Borrelia burgdorferi</i>VlsE in Three Host Species (2000)

VlsE, the variable surface antigen of Borrelia burgdorferi, contains a 26-amino-acid-long immunodominant invariable region, IR(6). In the present study, three overlapping 14-mer peptides reproducing the sequence of IR(6) were used as peptide-based enzyme-linked immunosorbent assay antigens to map this invariable region in infected monkeys, mice, and human Lyme disease patients. Antibodies of the two primate species appeared to recognize IR(6) as a single antigenic determinant, while mouse antibodies recognized multiple epitopes within this region.
pH-Metric Determination of Acid Numbers of Petroleum Oils without Titration (2000)

A pH-metric method was developed for determination of the acid numbers of oils containing organic and inorganic acids at levels <0.1 mg KOH/g oil. The method is based on rapid and complete extraction of acids from a test portion of oil into a special reagent, and measurement of the conditional pH of the mixture "oil-reagent" by a glass electrode. The method uses nontoxic reagents, is not time and labor consuming, and is cheap and simple enough for automation.
Grafting of cyclic carbonates onto cotton and modified cottons (1977)

Abstract Cyclic carbonates react with amines to form carbamates, with alcohols to form hydroxyalkylated products, and with dibasic acids or dibasic acids plus a glycol to form polyesters. These types of reactions between ethylene, propylene, or glycerine carbonate and cotton, either unmodified or modified to contain amine or carboxyl groups, were investigated. Effects of method of application, temperature, time of reaction, and pressure were studied. Temperature in excess of 100°C and reduced pressures were satisfactory for removing the water formed. Reaction between cyclic carbonates, dibasic acids, a glycol, and nonaqueously prepared carboxymethylated cotton in a vacuum oven yielded a fabric with conditioned and wet wrinkle recovery of approximately 300(W + F)°. Infrared spectra, wrinkle recovery, and weight gain indicated that crosslinks formed in reactions between unmodified or carboxymethylated cotton and the cyclic carbonate. Reactions with aminized or diethylaminoethylated cotton formed terminal grafts.
Three‐dimensional consensus structure of sst2‐selective somatostatin (SRIF) antagonists by NMR (2008)

The three-dimensional NMR structures of seven octapeptide analogs of somatostatin (SRIF), based on octreotide, with the basic sequence H-Cpa/Phe2-c[DCys3-Xxx7-DTrp/DAph(Cbm)8-Lys9-Thr10-Cys14]-Yyy-NH2 (the numbering refers to the position in native SRIF), with Xxx7 being Aph(Cbm)/Tyr/Agl(NMe,benzoyl) and Yyy being Nal/DTyr/Thr, are presented here. Most of these analogs exhibit potent and highly selective binding to sst2 receptors, and all of the analogs are antagonists inhibiting receptor signaling. Based on their consensus 3D structure, the pharmacophore of the sst2-selective antagonist has been defined. The pharmacophore involves the side chains of Cpa2, DTrp/DAph(Cbm)8, and Lys9, with the backbone for most of the sst2-selective antagonists comprised a Type-II' beta-turn. Hence, the sst2-selective antagonist pharmacophore is very similar to the sst2-selective agonist pharmacophore previously described.