gebhart/patrepeval huggingface dataset:
Association of intrauterine cigarette smoke exposure with indices of fetal lung maturation. (1992)

The timing of fetal lung maturation is regulated, at least in part, by the fetal endocrine milieu, which in turn may be influenced by environmental factors. Infants of smoking mothers are at decreased risk of neonatal respiratory distress syndrome (RDS), a disease of lung immaturity. Therefore, we measured fetal lung maturity and cigarette smoke exposure to determine whether the lungs of smoke-exposed fetuses mature more quickly and whether changes in maturation are associated with alterations in amniotic fluid (AF) cortisol levels. Amniotic fluid lecithin-sphingomyelin ratio (L/S) and saturated phosphatidylcholine levels were used as measures of lung maturity, while smoke exposure was assessed by measuring AF cotinine, a stable nicotine metabolite. Lung maturity was more advanced in smoke-exposed fetuses as measured by saturated phosphatidylcholine (P = .02) and L/S ratio (P = .04). Smoke-exposed fetuses attained sufficient lung maturity to minimize the risk of RDS approximately 1 week earlier than in unexposed fetuses. The AF of smoke-exposed fetuses also had higher levels of free, conjugated, and total cortisol. Acceleration of lung maturation in smoke-exposed fetuses is consistent with the decreased risk of RDS in infants of smoking mothers. Maternal smoking could influence lung maturation by directly or indirectly enhancing the production and/or secretion of cortisol. Despite the decreased risk of RDS, the developmental process by which smoke-exposed fetuses attain early pulmonary maturity is abnormal and may contribute to the decreased lung function and increased respiratory illness noted in infants of smoking mothers.
Rate constants for metam-sodium cleavage and photodecomposition in water (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRate constants for metam-sodium cleavage and photodecomposition in waterWilliam M. Draper and Diane E. WakehamCite this: J. Agric. Food Chem. 1993, 41, 7, 1129–1133Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://doi.org/10.1021/jf00031a023RIGHTS & PERMISSIONSArticle Views202Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (655 KB) Get e-Alerts Get e-Alerts
The effect of dissolved oxygen on PHB accumulation in activated sludge cultures (2003)

Nitrogen removal from wastewater is often limited by the availability of reducing power to perform denitrification, especially when treating wastewaters with a low carbon:nitrogen ratio. In the increasingly popular sequencing batch reactor (SBR), bacteria have the opportunity to preserve reducing power from incoming chemical oxygen demand (COD) as poly-beta-hydroxybutyrate (PHB). The current study uses laboratory experiments and mathematical modeling in an attempt to generate a better understanding of the effect of oxygen on microbial conversion of COD into PHB. Results from a laboratory SBR with acetate as the organic carbon source showed that the aerobic acetate uptake process was oxygen-dependent, producing higher uptake rates at higher dissolved oxygen (DO) supply rates. However, at the lower DO supply rates (k(L)a 6 to 16 h(-1), 0 mg L(-1) DO), a higher proportion of the substrate was preserved as PHB than at higher DO supply rates (k(L)a 30, 51 h(-1), DO >0.9 mg L(-1)). Up to 77% of the reducing equivalents available from acetate were converted to PHB under oxygen limitation (Y(PHB/Ac) 0.68 Cmol/Cmol), as opposed to only 54% under oxygen-excess conditions (Y(PHB/Ac) 0.48 Cmol/Cmol), where a higher fraction of acetate was used for biomass growth. It was calculated that, by oxygen management during the feast phase, the amount of PHB preserved (1.4 Cmmol L(-1) PHB) accounted for an additional denitrification potential of up to 18 mg L(-1) nitrate-nitrogen. The trends of the effect of oxygen (and hence ATP availability) on PHB accumulation could be reproduced by the simulation model, which was based on biochemical stoichiometry and maximum rates obtained from experiments. Simulated data showed that, at low DO concentrations, the limited availability of adenosine triphosphate (ATP) prevented significant biomass growth and most ATP was used for acetate transport into the cell. In contrast, high DO supply rates provided surplus ATP and hence higher growth rates, resulting in decreased PHB yields. The results suggest that oxygen management is crucial to conserving reducing power during the feast phase of SBR operation, as excessive aeration rates decrease the PHB yield and allow higher biomass growth.
Adaptive Video Streaming With Edge Caching and Video Transcoding Over Software-Defined Mobile Networks: A Deep Reinforcement Learning Approach (2019)

Both mobile edge cloud (MEC) and software-defined networking (SDN) are technologies for next generation mobile networks. In this paper, we propose to simultaneously optimize energy consumption and quality of experience (QoE) metrics in video streaming over software-defined mobile networks (SDMN) combined with MEC. Specifically, we propose a novel mechanism to jointly consider buffer dynamics, video quality adaption, edge caching, video transcoding and transmission. First, we assume that the time-varying channel is a discrete-time Markov chain (DTMC). Then, based on this assumption, we formulate two optimization problems which can be depicted as a constrained Markov decision process (CMDP) and a Markov decision process (MDP). Then, we transform the CMDP problem into regular MDP by deploying Lyapunov technique. We utilize asynchronous advantage actor-critic (A3C) algorithm, one of the model-free deep reinforcement learning (DRL) methods, to solve the corresponding MDP issues. Simulation results are presented to show that the proposed scheme can achieve the goal of energy saving and QoE enhancement with the corresponding constraints satisfied.
GI Risk and Risk Factors of NSAIDs (2006)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugs in the United States. Ulcers are found at endoscopy in 15% to 30% of patients using NSAIDs regularly. The annual incidence of upper gastrointestinal (GI) complications such as bleeding with regular NSAID use is approximately 1.0% to 1.5%, whereas the annual rate of upper GI clinical events (complicated plus symptomatic uncomplicated ulcers) is approximately 2.5% to 4.5%. Upper GI symptoms such as dyspepsia also occur in many patients taking NSAIDs--at a relative risk of about 1.5 to 2 compared with that in patients without NSAID use. Important risk factors for upper GI clinical events include older age, prior history of upper GI events, use of corticosteroids or anticoagulants, and high-dose or multiple NSAIDs (including NSAID plus low-dose aspirin). Lower GI clinical events such as bleeding may also occur with NSAIDs, although they are less common and less well studied than upper GI events. The decision to employ a protective strategy to decrease NSAID-associated GI clinical events is based on risk stratification. Strategies employed include the use of non-NSAID analgesics, use of lowest effective dose of NSAID, use of medical cotherapy (eg, proton pump inhibitor, misoprostol), or use of coxibs.
NONLINEAR WAVES AND DYNAMIC PRESSURES IN RECTANGULAR TUNED LIQUID DAMPER (TLD) (1989)

Tuned Liquid Damper (TLD) utilizing the motion of shallow liquid for absorbing and dissipating the vibrational energy is studied with emphasis on liquid motion. A mathematical model based on the nonlinear shallow water wave theory is presented to describe the liquid motion in a rectangular tank. Liquid damping is evaluated semianalytically and is included in the formulation. Mechanical properties of TLD are also experimentally investigated using the shaking table. It is found that the liquid motion in TLD is strongly nonlinear and reveals a hardening-spring property even under small excitation. Good agreements between the simulation and the experimental results are shown when no breaking wave occurs. The model presented in this study is expected to serve as a tool for TLD design.
ELISA detection of SARS-CoV-2 antibodies in saliva (2020)

To facilitate containment of the COVID-19 pandemic currently active in the United States and across the world, options for easy, non-invasive antibody testing are required. Here we have adapted a commercially available, serum-based enzyme-linked immunosorbent assay (ELISA) for use with saliva samples, achieving 84.2% sensitivity and 100% specificity in a set of 149 clinical samples. This strategy will enable widespread, affordable testing for patients who experienced this disease, whilst minimizing exposure risk for healthcare workers.
Initial results from the Sherbrooke avalanche photodiode PET scanner (2002)

The design features and engineering constraints of a PET system based on avalanche photodiode (APD) detectors have been described in a previous report. Here, the authors present the initial results obtained with the Sherbrooke APD-PET scanner, a very high spatial resolution device designed for dynamic imaging of small and medium-sized laboratory animals such as rats, cats, rabbits and small monkeys. Its physical performance have been evaluated in terms of resolution, sensitivity, count rate, random and scatter fractions, and activity recovery as a function of object size. The capabilities of the scanner for biomedical research applications have been demonstrated using phantom and animal studies.
Adaptively Biased Output Cap-Less NMOS LDO With 19 ns Settling Time (2018)

This paper presents an output external capacitor-less, fully integrated, fast settling NMOS low-dropout (LDO) regulator with adaptively biased error amplifier (EA) for system-on-chip core applications. The adaptive biasing technique increases both loop bandwidth and slew-rate of the LDO by 100% at full load condition without changing no-load quiescent current. Direct feedback to gate-to-source voltage of the NMOS regulation FET provides fast load transient response. The proposed LDO employs a cross-coupled common-gate input based EA, with transconductance boosting, achieving twice unity-gain bandwidth in comparison to a typical folded-cascode common-source input stage. Low output impedance of NMOS regulation stage and low input impedance of the EA reduce load dependent stability issue. The proposed regulator is designed and fabricated in a 0.18-μm CMOS technology with die-area of 0.21 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The LDO generates a regulated output voltage of 1.4-1.6 V from an input voltage of 1.6-1.8 V, consumes 133 μA quiescent current, and supports 0 pF to 50 pF load capacitance. Measured results show 166 mV undershoot with 19 ns settling time for a load step from 9 mA to 40 mA in 350 ps edge-time for zero-load capacitance. After using adaptive biasing, the settling time is reduced by 37% and 36% for 0 pF and 50 pF load, respectively.
Ceftriaxone Ameliorates Motor Deficits and Protects Dopaminergic Neurons in 6-Hydroxydopamine-Lesioned Rats (2011)

Parkinson's disease is caused by the degeneration of dopaminergic neurons in substantia nigra. There is no current promising treatment for neuroprotection of dopaminergic neurons. Ceftriaxone is a beta-lactam antibiotic and has been reported to offer neuroprotective effects (Rothstein, J.-D., Patel, S., Regan, M.-R., Haenggeli, C., Huang, Y.-H., Bergles, D.-E., Jin, L., Dykes, H.-M., Vidensky, S., Chung, D.-S., Toan, S.-V., Bruijn, L.-I., Su, Z.-Z., Gupta, P., and Fisher, P.-B. (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression Nature433, 73-77). In the present study, efficacy of ceftriaxone in neuroprotection of dopaminergic neurons and amelioration of motor deficits in a rat model of Parkinson's disease were investigated. Ceftriaxone was administrated in 6-hydroxydopamine-lesioned rats. Using behavioral tests, grip strength and numbers of apomorphine-induced contralateral rotation were declined in the ceftriaxone-treated group. More importantly, cell death of dopaminergic neurons was found to decrease. In addition, both the protein expression and immunoreactivity for GLT-1 were up-regulated. The present results strongly indicate that ceftriaxone is a potential agent in the treatment of Parkinson's disease.
Molecular Controls of Arterial Morphogenesis (2015)

Formation of arterial vasculature, here termed arteriogenesis, is a central process in embryonic vascular development as well as in adult tissues. Although the process of capillary formation, angiogenesis, is relatively well understood, much remains to be learned about arteriogenesis. Recent discoveries point to the key role played by vascular endothelial growth factor receptor 2 in control of this process and to newly identified control circuits that dramatically influence its activity. The latter can present particularly attractive targets for a new class of therapeutic agents capable of activation of this signaling cascade in a ligand-independent manner, thereby promoting arteriogenesis in diseased tissues.
A TRANSDISCIPLINARY JOURNEY: COURSE CREATION AT A SOUTH AFRICAN UNIVERSITY (2015)

The paper reviews the process involved in developing a transdisciplinary Master’s degree in Global Change. It first considers the meaning of the various disciplinarities before reviewing the team selection and development process. It provides an overview of the research behind and development of the curriculum, and discusses dealing with academic administration. It finally provides an overview of the teaching experience. Lessons learned cover teams, their selection and development; structures and the work required to address administrative challenges; course design and the issue of transdisciplinarity; and teaching, including the use of various alternative teaching and learning methods are presented. This is followed by a postscript - an overview of a course module and students’ responses.
Primary Tumors of the Spine in Children (1997)

Our current approach to treatment of spinal neoplasms varies from that used in the earlier part of the series and reflects the need for single stage complete resection and stabilization.
Si–H bond activation at {(NHC)2Ni0} leading to hydrido silyl and bis(silyl) complexes: a versatile tool for catalytic Si–H/D exchange, acceptorless dehydrogenative coupling of hydrosilanes, and hydrogenation of disilanes to hydrosilanes (2014)

The unique reactivity of the nickel(0) complex [Ni2(iPr2Im)4(COD)] (1) (iPr2Im = 1,3-di-isopropyl-imidazolin-2-ylidene) towards hydrosilanes in stoichiometric and catalytic reactions is reported. A series of nickel hydrido silyl complexes cis-[Ni(iPr2Im)2(H)(SiH(n-1)R(4-n))] (n = 1, 2) and nickel bis(silyl) complexes cis-[Ni(iPr2Im)2(SiH(n-1)R(4-n))2] (n = 1, 2, 3) were synthesized by stoichiometric reactions of 1 with hydrosilanes H(n)SiR(4-n), and fully characterized by X-ray diffraction and spectroscopic methods. These hydrido silyl complexes are examples where the full oxidative addition step is hindered. They have, as a result of the remaining Si-H interactions, remarkably short Si-H distances and feature a unique dynamic behavior in solution. Cis-[Ni(iPr2Im)2(H)(SiMePh2)] (cis-5) shows in solution at room temperature a dynamic site exchange of the NHC ligands, H-D exchange with C6D6 to give the deuteride complex cis-[Ni(iPr2Im)2(D)(SiMePh2)] (cis-5-D), and at elevated temperatures an irreversible isomerization to trans-[Ni(iPr2Im)2(D)(SiMePh2)] (trans-5-D). Reactions with sterically less demanding silanes give cis-configured bis(silyl) complexes accompanied by the release of dihydrogen. These complexes display, similarly to the hydrido silyl complexes, interestingly short Si-Si distances. Complex 1 reacts with 4 eq. HSi(OEt)3, in contrast to all the other silanes used in this study, to give the trans-configured bis(silyl) complex trans-[Ni(iPr2Im)2Ni(Si(OEt)3)2] (trans-12). The addition of two equivalents of Ph2SiH2 to 1 results, at elevated temperatures, in the formation of the dinuclear complex [{(iPr2Im)Ni-μ(2)-(HSiPh2)}2] (6). This diamagnetic, formal Ni(I) complex exhibits a long Ni-Ni bond in the solid state, as established by X-ray diffraction. The capability of the electron rich {Ni(iPr2Im)2} complex fragment to activate Si-H bonds was applied catalytically in the deuteration of Et3Si-H to Et3Si-D employing C6D6 as a convenient deuterium source. Furthermore, we show that 1 serves as a catalyst for the acceptorless dehydrogenative coupling of Ph2SiH2 to the corresponding disilane Ph2HSi-SiHPh2 and trisilane Ph2HSi-Si(Ph)2-SiHPh2, and the coupling of PhSiH3 to give a mixture of cyclic and linear polysilanes with high polydispersity (M(w) = 1119; M(n) = 924; M(w)/M(n) = 1.2). The capability of 1 to catalyze the formal reverse reaction as well is demonstrated by the hydrogenation of disilanes. The hydrogenation of the disilanes Ph2MeSi-SiMePh2 and PhMe2Si-SiMe2Ph to the corresponding hydrosilanes Ph2MeSi-H and PhMe2Si-H, respectively, proceeds effectively in the presence of 1 under very mild conditions (room temperature, 1.8 bar H2 pressure).
Exogenous Nerve Growth Factor Increases the Activity of High‐Affinity Choline Uptake and Choline Acetyltransferase in Brain of Fisher 344 Male Rats (1990)

The objective of this study was to determine the effect of age and chronic intracerebral administration of nerve growth factor (NGF) on the activity of the presynaptic cholinergic neuronal markers hemicholinium-sensitive high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) in the brain of Fisher 344 male rats. In 24-month-old rats, a substantial decrease in ChAT activity (30%) was measured in striatum, and decreases in HACU were found in frontal cortex (28%) and hippocampus (23%) compared with 4-month-old controls. Cholinergic neurons in brain of both young adult and aged rats responded to administration of exogenous NGF by increased expression of both phenotypes. In 4-month-old animals, NGF treatment at 1.2 micron/day resulted in increased activities of both ChAT and HACU in striatum (175 and 170%, respectively), frontal cortex (133 and 125%), and hippocampus (137 and 125%) compared with untreated and vehicle-treated 4-month-old animals; vehicle treatment had no effect on the activity of either marker. In 24-month-old animals treated with NGF for 2 weeks, ChAT activity was increased in striatum (179%), frontal cortex (134%), and hippocampus (119%) compared with 24-month-old control animals. Synaptosomal HACU in 24-month-old rats was increased in striatum (151%) and frontal cortex (128%) after 2 weeks of NGF treatment, but hippocampal HACU was not significantly different from control values.(ABSTRACT TRUNCATED AT 250 WORDS)
A comparative study on the electroluminescence properties of some terbium β-diketonate complexes (2001)

By comparing the phosphorescence spectra of Gd(acac)3 (acac = acetylacetone), Gd(TFacac)3 (TFacac = 1,1,1-trifluoroacetylacetone), the effects of fluorine replacement of hydrogen on the triplet state energy of the ligands were revealed. Fluorine can lower the triplet state energy of Hacac and make it more suitable for energy transfer towards the 5D4 state of terbium. Organic electroluminescent devices (OELDs) with the corresponding trivalent terbium complexes as emissive layers were fabricated. Triple-layer-type devices with a structure of glass substrate/ITO (indium tin oxide)/PVK [poly(N-vinylcarbazole)]/PVK∶Tb complex: PBD [2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole]/PBD/Al exhibit bright green luminescence upon applying a dc voltage. The luminance of a device with Tb(TFacac)3phen (1,10-phenanthroline) and Tb(TFacac)3 as emissive layer is higher than that of the corresponding devices with Tb(acac)3(phen) and Tb(acac)3 as emissive layers. The EL device with Tb(TFacac)3(phen) as emitter exhibits characteristic emission of Tb3+ ions with a maximum luminance of 58 cd m−2 at 25 V.
The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size (2007)

Exendin-4 (Ex4), a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake and suppress gastric emptying in rodents and humans. In this study we investigated the effects of peripheral administration of Ex4 on food intake and meal patterns in adult male rhesus macaques. Rhesus macaques (n = 4) that had been trained to lever press for food pellets were injected intramuscularly 15 min before the start of their 6-h daily feeding period. Ex4 was given at doses of 0.10, 0.32, 0.56, 1.0, and 3.0 microg/kg. Ex4 suppressed food intake in a dose-dependent manner, with the 3.0 microg/kg dose completely preventing feeding during the 6-h period and the 0.10 microg/kg dose suppressing intake by 17%. Doses of 0.32, 0.56, 1.0, and 3.0 microg/kg caused significant reductions in cumulative intake at all six hourly time points. Ex4 inhibited food intake through a specific effect on meal size. Meal size was significantly reduced in a dose-dependent manner with significant reductions at the 0.32 and 1.0 microg/kg doses (P < 0.05). Day 2 and 3 intakes returned to baseline levels with no compensation for Ex4-induced feeding suppression. Administration of doses of 0.32 and 0.56 microg/kg Ex4 over 5 consecutive days led to sustained reductions in intake with no evidence of compensation. Again, these reductions were due to specific effects on meal size. These results demonstrate that activation of GLP-1 pathways has potent effects on the controls of meal size and overall food intake in a nonhuman primate model.
Seismic inversion at Pike's Peak, Saskatchewan (2000)

An acoustic impedance inversion of a 2-D seismic swath line from the Pikes Peak Heavy Oil field in Saskatchewan, Canada is presented in this report. The results indicate a low impedance zone where steam has been injected into the reservoir formation, the Waseca member of the Mannville Group. The very high impedance Devonian carbonates are also shown. One well located on the 2-D line was used to constrain the interpretation and impedance values for the model-based inversion. Several modules from the inversion software package, Jason Geoscience Workbench, are described as they pertain to the inversion process.