gebhart/patrepeval huggingface dataset:
Principal component filter banks for optimal multiresolution analysis (1995)

An important issue in multiresolution analysis is that of optimal basis selection. An optimal P-band perfect reconstruction filter bank (PRFB) is derived in this paper, which minimizes the approximation error (in the mean-square sense) between the original signal and its low-resolution version. The resulting PRFB decomposes the input signal into uncorrelated, low-resolution principal components with decreasing variance. Optimality issues are further analyzed in the special case of stationary and cyclostationary processes. By exploiting the connection between discrete-time filter banks and continuous wavelets, an optimal multiresolution decomposition of L/sub 2/(R) is obtained. Analogous results are also derived for deterministic signals. Some illustrative examples and simulations are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Performance Evaluation of Cellular Networks with Mobile and Fixed Relay Station (2006)

It is foreseen that the next generation of cellular network would integrate the relaying or multihop scheme. In a multihop cellular architecture, the users are not only able to communicate directly to the base station (BS) but can also use some relay stations to relay their data to the BS. These relay stations can either be the users' mobile station (i.e. mobile relay station) or some low cost station placed at specific location (i.e. fixed relay station). The main objective of this paper is to compare the difference between the relaying network architecture with mobile or fixed relay station as well as their performance gain. At first, the different advantages and disadvantages for each relay station method are given. Then, the capacity gains of the two methods are compared with a dynamic system level simulator. For this we integrate the relay station into conventional cellular networks using the UMTS FDD air interface. The results show that under certain conditions the uplink capacity gain of 35% is readily achievable for both form of relay station.
Ethylenediamine Tetraacetato Trioxomolybdate(VI) and Tungstate(VI) and their Reactions with Hydrogen Peroxide (2006)

Investigation of the reactions between ethylenediamine tetraacetic acid with molybdate(VI) and tungstate(VI) resulted in the isolations of dimeric complexes Na2K2[Mo2O6(Edta)] · 10H2O (1) and Na4[W2O6(Edta)] · 8H2O (2) (H4Edta=ethylenediamine tetraacetic acid) in a wide range of pH values 5–10. The new tungstate complex is resistant for the reaction of hydrogen peroxide, while the reaction of its molybdate homolog results in the isolation of peroxo tetramolybdate(VI) K8[Mo4O12(O2)2] (3). The three complexes have been characterized by elemental analyses, IR, NMR and X‐ray structural analyses. The anions of the complexes 1 and 2 contain two metal atoms and one Edta ligand. Each metal atom is tridentately coordinated by nitrogen and carboxyl groups of Edta ligand, making metal atom six‐coordinate.
An iterative diffusion algorithm for part disassembly (2004)

The paper presents an efficient collision-free path planner for mechanical part disassembly simulation. The principle of the algorithm involves computing a first path while allowing some penetration within the obstacles. Then the current paths are iteratively re-shaped by decreasing the allowed penetration threshold. The process is controlled by a dynamic collision checker. The cases of failure of the iterative process are automatically detected and solved.
A Fully Integrated Spread Spectrum Clock Generator (2006)

This paper presents a fully-integrated spread-spectrum clock generator (SSCG) with triangular modulation. This SSCG with spread ratios of 0.5% and 1% has been fabricated in 0.35mum double-poly quadruple-metal CMOS process. It consumes 140mW at 400MHz output from the supply of 3.3V. The required capacitance is equivalently reduced by a factor of 10 compared with the conventional one
An Efficient Algorithm for Segmenting Warped Text-Lines in Document Images (2013)

Warped text-lines often appear whenever one performs the digitalization of bound documents using flatbed scanners or digital cameras. Compensating such distortion is an important pre-processing step in document transcription via OCR, for instance. This paper presents an efficient algorithm for text-line segmentation for document images. A typographic study and parameter tuning are done yielding into high values for precision, recall and f-measure metrics. The method presented outperforms the competing algorithms using a public available dataset.
Prediction of Forming Limit Diagram (FLD) and Effect of Work Hardening Property on FLD of Sheet Metals (2002)

The necking limit diagram NLD and the forming limit diagram FLD under the wide-range bi-axial tensile stress conditions were obtained by using various sheet metals of steels, Al-alloys and a copper. The good correlation between the limited strain values of NLD and FLD and the mechanical properties of total elongation and r-value etc. were obtained. Moreover, the strain dependency of the work hardening coefficient n-value in higher strain area was different according to each material. The complex value of n-value and r-value was defined as the equivalent work hardening coefficient neq-value in higher strain area. And when the neq-value was substituted to Gotoh's modeling of localized necking limited strain, FLD that accuracy is high was able to be predicted.
Ru(<scp>ii</scp>)-Catalyzed C–H activation and annulation of salicylaldehydes with monosubstituted and disubstituted alkynes (2016)

The Ru(ii)-catalyzed C-H activation and annulation reaction of salicylaldehydes and disubstituted alkynes affords chromones in high yields. This reaction also works with terminal alkynes and tolerates a wide range of sensitive functional groups. The selectivity pattern of this Ru(ii)-catalyzed annulation reaction is different from the known Au(i), Rh(iii)-catalyzed annulation reactions of salicylaldehydes and terminal alkynes.
Mode-division multiplexing in fibre-optic communications based on orbital angular momentum (2013)

The possibility of using optical vortices with different values of topological charge l, and hence with different values of the orbital angular momentum (OAM), for mode-division multiplexing in optical fibres is here investigated. Two OAM modes with l equal to 0 and 1, respectively, are multiplexed in a few-mode fibre and then demultiplexed after a fibre propagation of 200 m. Such modes are spatially separated at the two output ports of a Mach–Zehnder interferometer with mutually 90°-rotated Dove prisms in the two arms. It is also shown how to generalize this demultiplexing scheme, which is all-optical, passive and in principle without splitting losses, in order to deal with a higher number of vortices propagating in the fibre. Therefore the proposed mode-division multiplexing technique based on OAM modes is very promising for increasing the capacity of fibre-optic transmission systems in an energy-saving efficient way, without the high power consumption of modal demultiplexing exploiting real-time electronic post-processing.
Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase. (2003)

Expression of drug-resistant forms of dihydrofolate reductase (DHFR) in hematopoietic cells confers substantial resistance of animals to antifolate administration. In this study, we tested whether the chemoprotection conferred by expression of the tyrosine-22 variant DHFR could be used for more effective therapy of the 32Dp210 murine model of chronic myeloid leukemia (CML). Administration of the maximum tolerated dose of trimetrexate (TMTX) with the nucleoside transport inhibitor prodrug nitrobenzylmercaptopurine ribose-5'-monophosphate (NBMPR-P) inhibited 32Dp210 tumor progression in mice engrafted with transgenic tyrosine-22 DHFR marrow and improved survival of tumor-bearing animals as long as drug administration was continued. NBMPR-P coadministration was necessary for maximal tumor inhibition, as administration of TMTX alone delayed but did not prevent tumor progression. The chemoprotection afforded by engraftment with transgenic tyrosine-22 DHFR marrow was necessary for effective chemotherapy, as normal mice lacking transgenic marrow could not tolerate the higher TMTX dose (60 mg/kg/day) administered to mice with transgenic marrow, and the decreased dose of TMTX with NBMPR-P tolerated by normal tumor-bearing animals did not inhibit tumor progression or improve animal survival. We conclude that TMTX with NBMPR-P inhibits tumor progression in the 32Dp210 model of CML in animals engrafted with drug-resistant tyrosine-22 DHFR transgenic marrow, and that based on this model the introduction of a drug-resistant DHFR gene into marrow combined with TMTX and NBMPR-P administration may provide an effective treatment for CML.
Self-Assembly Aggregation of Highly Stable Copolynorbornenes with Amphiphilic Architecture via Ring-Opening Metathesis Polymerization (2005)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSelf-Assembly Aggregation of Highly Stable Copolynorbornenes with Amphiphilic Architecture via Ring-Opening Metathesis PolymerizationDer-Jang Liaw, Tsang-Pin Chen, and Ching-Cheng HuangView Author Information Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan 106 Cite this: Macromolecules 2005, 38, 8, 3533–3538Publication Date (Web):March 25, 2005Publication History Received26 September 2004Revised3 February 2005Published online25 March 2005Published inissue 1 April 2005https://pubs.acs.org/doi/10.1021/ma048015vhttps://doi.org/10.1021/ma048015vbrief-reportACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views571Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon,Cations,Copolymers,Polymers,Resonance structures Get e-Alerts
Targeting the endothelin system: novel therapeutic options in gynecological, urological and breast cancers (2008)

The endothelin system comprises the three peptide hormones endothelin (ET)-1, -2, -3, their G protein-coupled receptors, endothelin-A-receptor (ETAR) and endothelin-B-receptor (ETBR), and the enzymes of endothelin biosynthesis and degradation. In the past two decades, an impressive amount of data has been accumulated investigating the role of the endothelin system in a variety of malignancies. In many cancers, ET-1/ETAR interaction induces proliferation, angiogenesis, antiapoptosis and resistance to chemotherapy. Data indicate a pivotal role of the endothelin system in tumorigenesis, local progression and metastasis. Subsequently, novel drugs have been designed inhibiting ET-1 biosynthesis or ETAR interaction. A wide range of preclinical data is available on the role of ETAR antagonists in gynecological, urological and breast cancers providing evidence for their antiangiogenic, proapoptotic and growth inhibitory effects. Of particular interest is the anti-invasive and antimetastatic efficacy of ETAR antagonists and synergism when co-administered with established cancer therapies. Data indicate a future role of ETAR antagonists in oncologic therapies.
Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network (2014)

Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S‐QA‐PEI). The synthesized S‐QA‐PEI particles were identified with a slight particle size increase of 2–3 µm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, −16.7 ± 5.11 mV, the prepared S‐QA‐PEI particles are positively charged, +50–60 mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity. Copyright © 2014 John Wiley & Sons, Ltd.
Beyond MLS-Occupied Hall Measurement with FFT Techniques (1996)

The study of hall acoustics continues to suffer from the difficulties of obtaining accurate measurements of halls in the presence of audience and musicians. An effective measurement technique must be fast, accurate, pleasant, and entertaining. It has become routine to measure unoccupied halls using a Maximum Length Sequence (MLS) as a stimulus. Originally chosen because MLS stimuli can be deconvolved without multiplication, there are a number of disadvantages of MLS in occupied hall measurement. Current computers provide fast and efficient deconvolution of arbitrary stimuli, which allows us to design a stimulus specifically for occupied halls. This paper will review currently available measurement methods, present MATLAB routines for generating and deconvolving effective stimuli, and show the results in occupied halls. The routines allow a complete series of binaural hall measurements with three source positions to be completed in less than 1.5 minutes while entertaining the musicians and audience. Good results can be obtained with time-variant enhancement systems, and results can be recorded with ordinary cassette recorders. A laptop computer equipped with a 16 bit sound card can be used for signal generation and analysis.
Prediction of anaphylaxis during peanut food challenge: usefulness of the peanut skin prick test (SPT) and specific IgE level (2010)

Cutoffs (decision points) of the peanut skin prick test (SPT) and specific IgE level for predicting peanut allergy have been proposed. It is not known whether decision points indicating a significant risk of severe reactions on challenge differ from those indicating probable allergy. We aimed at determining the usefulness of allergy tests for predicting the risk of anaphylaxis on challenge following the ingestion of up to 12 g of peanut in peanut-sensitized children. Children attending the Allergy Clinic who had a positive peanut SPT and completed open-label in-hospital peanut challenges were included. The challenge protocol provided for challenges to be continued beyond initial mild reactions. Eighty-nine in-hospital peanut challenges were performed. Thirty-four were excluded as the challenge was not completed, leaving 55 for analysis. Children who completed the challenge and did not react (n = 28) or reacted without anaphylaxis (n = 6) represented the comparison group (n = 34). The study group comprised 21 children whose challenge resulted in anaphylaxis. The mean peanut SPT wheal size and specific IgE level were associated with the severity of reactions on challenge. Among the 21 children, who developed anaphylaxis, in only 3 cases was anaphylaxis the initial reaction. Unexpectedly, a history of anaphylaxis was not predictive of anaphylaxis on challenge. Anaphylaxis developed at cumulative doses of peanut ranging from 0.02 to 11.7 g. Provided that a fixed amount of peanut is ingested, available tests for peanut allergy may assist in predicting the risk of anaphylaxis during challenge in peanut-sensitized children.
Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation (2017)

We recently proved that exosomes engineered in vitro to deliver high amounts of HPV E7 upon fusion with the Nef<sup>mut</sup> exosome-anchoring protein elicit an efficient anti-E7 cytotoxic T lymphocyte immune response. However, in view of a potential clinic application of this finding, our exosome-based immunization strategy was faced with possible technical difficulties including industrial manufacturing, cost of production, and storage. To overcome these hurdles, we designed an as yet unproven exosome-based immunization strategy relying on delivery by intramuscular inoculation of a DNA vector expressing Nef<sup>mut</sup> fused with HPV E7. In this way, we predicted that the expression of the Nef<sup>mut</sup>/E7 vector in muscle cells would result in a continuous source of endogenous (ie, produced by the inoculated host) engineered exosomes able to induce an E7-specific immune response. To assess this hypothesis, we first demonstrated that the injection of a Nef<sup>mut</sup>/green fluorescent protein-expressing vector led to the release of fluorescent exosomes, as detected in plasma of inoculated mice. Then, we observed that mice inoculated intramuscularly with a vector expressing Nef<sup>mut</sup>/E7 developed a CD8<sup>+</sup> T-cell immune response against both Nef and E7. Conversely, no CD8<sup>+</sup> T-cell responses were detected upon injection of vectors expressing either the wild-type Nef isoform of E7 alone, most likely a consequence of their inefficient exosome incorporation. The production of immunogenic exosomes in the DNA-injected mice was formally demonstrated by the E7-specific CD8<sup>+</sup> T-cell immune response we detected in mice inoculated with exosomes isolated from plasma of mice inoculated with the Nef<sup>mut</sup>/E7 vector. Finally, we provide evidence that the injection of Nef<sup>mut</sup>/E7 DNA led to the generation of effective antigen-specific cytotoxic T lymphocytes whose activity was likely part of the potent, therapeutic antitumor effect we observed in mice implanted with TC-1 tumor cells. In summary, we established a novel method to generate immunogenic exosomes in vivo by the intramuscular inoculation of DNA vectors expressing the exosome-anchoring protein Nef<sup>mut</sup> and its derivatives.
The Development and Application of Computational Methods for the Prediction of G Protein-Coupled Receptor Structures (2010)

Computational methods for the prediction of G protein-coupled receptor (GPCR) structures were applied to serotonin receptors, and new methods were developed to predict an orphan GPCR structure. First, the MembStruk procedure was used to predict the structures of the serotonin 2b and 2c receptors. Ligand binding sites for agonists and antagonists were predicted for both receptors. In addition, the SAR data for a series of psilocybin analogs bound to serotonin 2c were predicted. There was good agreement with binding and mutagenesis experiments. A new structure prediction procedure called SuperBiHelix was developed to predict an ensemble of low-lying structures. SuperBiHelix samples the tilt and sweep angles of the transmembrane helices along with the rotation of the helices along the helical axes. The procedure was validated on the β2-adrenergic receptor and A2A adenosine receptor crystal structures. This procedure was then used to predict the structure of GPR88, an orphan receptor. GPR88 has been identified as a novel target for psychiatric disorders. Three lipids were predicted to bind to GPR88. The head group of a lipid would bind to R113(3) and R116(3) at the extracellular side of the receptor. The lipid tail would bind in an aliphatic pocket in the TM2-TM3-TM6-TM7 region. The predicted bound complexes offer good suggestions for binding and mutagenesis experiments that could help validate the proposed structures.
The effect of fastigial nucleus electrical stimulation on proteins regulating apoptosis in patients with cerebral infarction (2003)

Objective: To observe the effect of fastigial nucleus electrical stimulation on sAPO-1/Fas and Bcl-2 in patients with cerebral infarction. Methods: 40 patients (within 3days after onset) were divided into stimulation group and control group. The neurological score and the levels of sAPO-1/Fas and Bcl-2 in CSF and serum were estimated by SNSS and ELISA respectively. Results; Significantly increased CSF levels of sAPO-1/Fas and serum levels of Bcl-2 were observed after fastigial nucleus electrical stimulation for 10 days; the neurological score was also significantly increased ofter stimulation compare with control. Conclusions: Fastigial nucleus electrical stimulation can increase the neurological score and the levels of sAPO-1/Fas and Bcl-2 in acute stroke,this may play a role in treating cerebral infarction.
TACE inhibition: a new approach to treating inflammation (2002)

Clinical trials showing the benefits of reducing the effects of TNF- alpha in rheumatoid arthritis have highlighted the key role of the cytokine TNF- alpha in this inflammatory condition. A new approach to reducing the effects of TNF- alpha is to decrease its synthesis by inhibiting TNF- alpha converting enzyme with GW3333. In rat models of arthritis, GW3333 has some beneficial effects. Further longer-term studies of GW3333 in animal models are required to determine whether its benefit is maintained. TACE inhibition may represent a new approach to treating inflammation.
Deficient C-oxidation of nicotine* (1995)

In most people, nicotine is extensively (70% to 80%) metabolized to cotinine by C-oxidation. In a clinical trial, a 57-year-old woman was found to have the expected plasma levels of nicotine but unusually low plasma levels of cotinine both when smoking cigarettes and while receiving transdermal nicotine. To characterize her metabolism, simultaneous infusions of deuterium-labeled nicotine (d2) and cotinine (d4) were administered, with comparison to 20 other control smokers. The clearance of nicotine was unusually low (6.5 ml/min/kg versus 17.2 ml/min/kg), and the half-life of nicotine significantly longer (348 minutes versus 138 minutes) in the index case subject compared with the control subjects. The clearance of cotinine was normal. The index case subject converted only 9% of nicotine to cotinine, compared with 72% for the control subjects. As far as we know, this is the first person with deficient C-oxidation of nicotine to be characterized. Deficient C-oxidation of nicotine is associated with a long half-life of nicotine and deficient generation of cotinine, both of which could influence the risks and addictiveness of tobacco use in affected individuals.