gebhart/patrepeval huggingface dataset:
Heme oxygenase-1 and acute kidney injury (2013)

Recent contributions support, and elucidate the basis for, the induction of HO-1 as a protectant against AKI. Translating such therapeutic potential into a therapeutic reality requires well tolerated and effective modalities for upregulating HO-1 and/or administering its products, which, optimally, should be salutary even when AKI is already established.
Association of lipid peroxidation and polymerization of membrane proteins with erythrocyte aging. (1981)

The addition of malondialdehyde to erythrocytes in vitro causes a decrease in bands 1 and 2 of spectrin and an increase in high molecular weight protein polymers. Additionally, this agent causes the formation of fluorscent chromolipids characteristic of those produced during the peroxidation of endogenous membrane phospholipids. These same alterations in proteins and lipids are observed in the membranes of older cells fractionated from freshly drawn blood and in the membranes of reticulocytes induced by treatment of animals with phenylhydrazine, but not in reticulocytes induced by bleeding. The former reticulocytes have a much shorter half-life in the circulation than do either normal erythrocytes or reticulocytes produced consequent to bleeding. These experiments and the apparent paradox of "young" reticulocytes with short half-lives suggest that the in vivo polymerization of membrane proteins consequent to radical-induced peroxidation of membrane lipids may contribute to the altered rheological behavior and hence to the splenic sequestration of cells. They also suggest that increases in intrinsic membrane rigidity due to lipid peroxidation, malondialdehyde, and protein polymerization may be a common feature of both aging in normal erythrocytes and in the accelerated aging that accompanies the administration of radical-generating, hemolytic agents. However, it is cautioned that other polymerization reactions involving disulfides, calcium, or direct radical attack on protein monomers may also be important determinants of the visco-elastic properties of erythrocyte membranes.
CAD-compatible high-speed CMOS/SIMOX gate array using field-shield isolation (1995)

A specific 0.5 /spl mu/m CMOS/SIMOX technology was developed for a gate array/sea of gate (SOG) using field-shield (FS) isolation to overcome a pending problem of source-to-drain breakdown voltage (BV/sub ds/) lowering. FS isolation is capable of improving BV/sub ds/ because surplus holes generated by impact ionization at the drain region are collected through the body region under the FS gate. BV/sub ds/ was maintained at a level of junction breakdown before reaching the punchthrough limitation at a gate length of around 0.3 /spl mu/m using the FS isolation. The FS isolation technique was successfully applied to an SOG gate array on a SIMOX substrate. The gate array has the same area as that on the bulk-Si and is compatible to a conventional bulk-Si CAD system because the layout is basically the same. A 53-stage ring oscillator fabricated on the FS isolated SOG gate array exhibited 1.7 times higher speed operation than that on a bulk-Si counterpart, keeping low power consumption characteristics up to a drain voltage of 3 V.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adsorption and Desorption of CO2 on Solid Sorbents (2001)

Fossil fuels supply more than 98 % of the world’s energy needs. However, the combustion of fossil fuels is one of the major sources of the green house gas CO 2. It is necessary to develop technologies that will allow us to utilize the fossil fuels while reducing the emissions of green
Big Data Analytics And Data Security In The Cloud Via Fully Homomorphic Encryption (2015)

This paper describes the problem of building secure<br> computational services for encrypted information in the Cloud<br> Computing without decrypting the encrypted data; therefore, it meets<br> the yearning of computational encryption algorithmic aspiration<br> model that could enhance the security of big data for privacy,<br> confidentiality, availability of the users. The cryptographic model<br> applied for the computational process of the encrypted data is the<br> Fully Homomorphic Encryption Scheme. We contribute a theoretical<br> presentations in a high-level computational processes that are based<br> on number theory and algebra that can easily be integrated and<br> leveraged in the Cloud computing with detail theoretic mathematical<br> concepts to the fully homomorphic encryption models. This<br> contribution enhances the full implementation of big data analytics<br> based cryptographic security algorithm.
Effects of High-Pressure CO<sub>2</sub>Processing on Flavor, Texture, and Color of Foods (2013)

High-pressure CO2 (HPCD) is a pasteurization method that inactivates microorganism and enzymes through molecular effects of CO2 under pressures below 50 MPa without exposing foods to adverse effects of heat. Thermal pasteurization can impart undesirable changes on organoleptic and nutritional quality of the foods, which can reduce sensory perception and consumer acceptance of the foods. As a novel nonthermal processing technique, HPCD does avoid drawbacks such as loss of flavor, denaturation of nutrients, production of side toxic reactions, as well as changes in physical, mechanical, and optical properties of the food materials involved in the processing. This review gives a survey and analysis of recent publications regarding the effects of HPCD on the flavor, texture and color of processed foods, and possible mechanisms explaining HPCD technique on the flavor, texture, and color of the foods were discussed.
Building and Managing Enterprise-Wide Web Portals - Tutorial (2005)

This tutorial aims at taking the participants through the concept and architecture of Web services, their components such as servlets, and JSPs; concept and usage of WSDL, and JAX-RPC-based web services. Furthermore, we introduce the concept of portals, portal page and portlets. A small part of the tutorial is devoted to the deployment practices of both - Web services and portlets. Relevant deployment descriptors - portlet.xml, web.xml - and the structure of the deployment directories are discussed. The closing remarks concentrate on the development issues from the perspective of the development manager and developer (programmer). The tutorial is based on the book “Building and Managing Enterprise wide Web services and portals” published by Idea Group. The additional material is available from http://neptune .netcomp .monash.edu.au/cpe4004/index.html .
Alkylation of quinazoline‐2,4(1<i>H</i>,3<i>H</i>)‐diones with 1,4‐dibromo‐2‐methylbut‐2‐ene under phase‐transfer‐catalysis (1993)

Abstract Quinazoline‐2,4(1 H ,3 H )‐dione ( 1 ) was reacted with 1,4‐dibromo‐2‐methylbut‐2‐ene ( 2 ) to give two dialkylated products and two monoalkylated products. The reaction of 6,7‐dimethoxyquinazoline‐2,4(1 H ,3 H )‐dione ( 8 ) with 1,4‐dibromo‐2‐methylbut‐2‐ene ( 2 ) resulted in the formation of three dialkylated products.
Nonintrusive Biological Signal Monitoring in a Car to Evaluate a Driver’s Stress and Health State (2009)

Nonintrusive monitoring of a driver's physiological signals was introduced and evaluated in a car as a test of extending the concept of ubiquitous healthcare to vehicles. Electrocardiogram, photoplethysmogram, galvanic skin response, and respiration were measured in the ubiquitous healthcare car (U-car) using nonintrusively installed sensors on the steering wheel, driver's seat, and seat belt. Measured signals were transmitted to the embedded computer via Bluetooth(R) communication and processed. We collected and analyzed physiological signals during driving in order to estimate a driver's stress state while using this system. In order to compare the effect of stress on physical and mental conditions, two categories of stresses were defined. Experimental results show that a driver's physiological signals were measured with acceptable quality for analysis without interrupting driving, and they were changed meaningfully due to elicited stress. This nonintrusive monitoring can be used to evaluate a driver's state of health and stress.
2DEG-HEATED ALGAN/GAN MICRO-HOTPLATES FOR HIGH-TEMPERATURE CHEMICAL SENSING MICROSYSTEMS (2016)

Fully-suspended AlGaN/GaN micro-hotplates that leverage self-heating of the two-dimensional electron gas (2DEG) have been modeled, micro-fabricated, and characterized at elevated ambient temperatures (from 25C to 600C in air). An input power of ~75 mW heated the micro-hotplates to approximately 270C from 25C ambient conditions. In addition, finite element analysis (FEA) showed high-temperature uniformity across the micro-hotplate (<1% variation) and fast transient response times (~2 ms rise and fall times). These results support the use of the AlGaN/GaN-on-Si platform for high-temperature activation of chemical sensing catalysts and in-situ chemical sensing within high-temperature environments (e.g., combustion exhaust, industrial process, and downhole).
Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. (1995)

In a search for retinoid X receptor-like molecules in Drosophila, we have identified an additional member of the nuclear receptor superfamily, XR78E/F. In the DNA-binding domain, XR78E/F is closely related to the mammalian receptor TR2, as well as to the nuclear receptors Coup-TF and Seven-up. We demonstrate that XR78E/F binds as a homodimer to direct repeats of the sequence AGGTCA. In transient transfection assays, XR78E/F represses ecdysone signaling in a DNA-binding-dependent fashion. XR78E/F has its highest expression in third-instar larvae and prepupae. These experiments suggest that XR78E/F may play a regulatory role in the transcriptional cascade triggered by the hormone ecdysone in Drosophila.
TNF as Biomarker for Rapid Quantification of Active Staphylococcus Enterotoxin A in Food (2012)

Staphylococcus aureus is a major bacterial pathogen which causes clinical infections and food poisoning. This bacterium produces a group of twenty-one enterotoxins (SEs). These enterotoxins have two separate but related biological activities. They cause gastroenteritis and function as superantigens that activate large numbers of T cells. The current method for detection of enterotoxins activity is an in vivo monkey or kitten bioassay; however, this method is not practical to test on a large number of samples. Several immunological assays have been developed however, but these assays cannot distinguish between active toxin which causes food poisoning and inactive toxin, which can bind antibody, but shows no toxicity. The current study demonstrates that short term ex vivo exposure of primary naïve CD4(+) T-cells or splenocytes to SEA induces differential expression and secretion of tumor necrosis factor (TNF) protein. We used immunomagnetic beads coated with anti-SEA antibody to specifically isolate SEA from food. After the eluted toxin was added to the cells SEA biological activity was measured by quantifying TNF protein expression or secretion.
Joint audio-video object localization using a recursive multi-state multi-sensor estimator (2002)

Object localization based on audio and video information is important for the analysis of dynamic scenes, such as video conferences or traffic situations. In this paper, we view the the dynamic audio-video object localization problem as a joint recursive estimation problem. It is solved using a decentralized Kalman filter fusing both audio and video position estimates. To better take into account different object maneuvers, multiple state-space equations are also incorporated. The result is a recursive multi-state multi-sensor estimator. Experiments show that it yields significantly improved joint position estimates compared to results achieved by using either an audio or a video system only.
Tuning of Field-Oriented Induction Motor Controllers for High-Performance Applications (1986)

A tuning procedure for high-performance (e.g., axis feed type) applications of feedforward field-oriented controllers is developed and demonstrated. The theoretical basis of the procedure is explained via a novel form of dq vector diagram. This diagram displays both steady and transient states simultaneously. This format also provides substantial insight into the expected behavior of mistuned controllers, especially for analyzing transient torque performance. The procedure is unambiguous to implement, and it requires no additional sensors beyond those required for the feedforward controller.
Diagnosis and management of neuropathic pain (2009)

#### Summary points

Neuropathic pain arises from damage, or pathological change, in the peripheral or central nervous system. It is usually a chronic condition that can be difficult to treat because standard treatment with conventional analgesics does not typically provide effective relief of pain. Patients with neuropathic pain commonly present to primary care professionals, but making a diagnosis may be difficult. Neuropathic pain is usually associated with substantially greater impairment of quality of life compared with other types of chronic pain, and the disorder is a large cost burden on healthcare services. In this review, we provide an overview of published evidence to help clinicians recognise and manage patients with neuropathic pain.

A group of specialists of the International Association for the Study of Pain defines neuropathic pain as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system.”1 In contrast to inflammatory or nociceptive pain, which is caused by actual tissue damage or potentially tissue damaging stimuli, neuropathic pain is produced either by damage to, or pathological change in, the peripheral or central nervous system, the system that normally signals pain. As such, the term neuropathic pain represents a varying set of symptoms rather than a single diagnosis.

Damage to the somatosensory system can provoke a range of responses; an absence of sensation and pain is probably a more common response than new onset of …
Comparision of the risk of cardiovascular events and death in patients treated with degarelix compared with LHRH agonists. (2013)

42 Background: LHRH agonists are used to treat patients (pts) with advanced prostate cancer and have been associated with an increased risk of cardiovascular (CV) events and related deaths. Degarelix is a GnRH antagonist that appears to mitigate this risk. Methods: Results were pooled from 2328 pts participating in 6 prospective randomised trials. Most pts (n=1,686) received 1 year of GnRH antagonist or LHRH agonist treatment; the remainder (n=642) had 3–7 months’ treatment. Data were classified based on the MedDRA system and analysed using Kaplan Meier plots and a Cox proportional hazard model. Event analysis was based on death from any cause or CV event defined as arterial embolic/thrombotic; haemorrhagic or ischemic cerebrovascular; myocardial infarction or other ischemic heart disease. High risk pts were defined as men with a baseline CV disease (CVD) history. Results: Treatment groups (GnRH antagonist, n=1,491 [degarelix]; LHRH agonist, n=837 [goserelin, n=458; leuprolide, n=379]) were balanced for baseline characteristics and CVD history (31% vs. 29%). Characteristics associated with CVD (e.g. statin medication, elevated blood pressure, diabetes, cholesterol >6.2 mmol/L) were similar between groups. The risk of a CV event or death was significantly lower in pts receiving degarelix during the first year of treatment (see Table). In pts with baseline CVD the findings remained significant. In pts with no baseline CVD, there was no difference in subsequent CVD events or death in either group. In analysis by time to CV event only in all pts and pts with baseline CVD (see Table), men receiving GnRH antagonist had a significantly lower risk of CV events. Conclusions: In all pts treated with a GnRH antagonist (degarelix) risk of a CV event or death was significantly lower than in pts receiving an LHRH agonist over a treatment period of up to 1 year. In pts with baseline CVD, risk reduction remained significant at ~50%. [Table: see text]
Nanosilver preform assisted die attach for high temperature applications (2015)

Using sintered silver as a high temperature die attach material has recently evoked much interest. The emergence of pressureless sintering using a silver nanoparticle based paste, however, has been of particular importance. Despite its numerous advantages and favorable properties, the die attach procedure using nanosilver paste has its share of problems. A reliable and repeatable process producing a strong and consistent bond is required, especially if a need arises to integrate this technology into high volume production. In this paper, a technique has been explored in which preforms made of nanosilver particles have been fabricated and used for die attachment. The preforms can be tailored to produce custom bond line thicknesses and can be cut to fit die spanning a range of different sizes. The die shear strength of a 1.5 mm x 1.5 mm Si die has been found to be 3.75 times larger using the proposed technique as compared to the conventional nanosilver process.
The pseudo-well technique - A Tool for statistical calibration of seismic data in a field with limited well control (1994)

New tools for 3D reservoir modelling, such as geostatistical simulations, are making integration of different types of data a practical possibility. Well data and a-priori geological information are always used for reservoir description. Seismic data can be integrated into reservoir modelling through 2 main approaches: either a semi-deterministic (Le seismic followed by lithological inversions), or a probabilistic one, also known as Statistical Calibration.
Opioids and the immune system (2006)

Opioid compounds such as morphine produce powerful analgesia that is effective in treating various types of pain. In addition to their therapeutic efficacy, opioids can produce several well known adverse events, and, as has recently been recognized, can interfere with the immune response. The immunomodulatory activities of morphine have been characterized in animal and human studies. Morphine can decrease the effectiveness of several functions of both natural and adaptive immunity, and significantly reduces cellular immunity. Indeed, in animal studies morphine is consistently associated with increased morbidity and mortality due to infection and worsening of cancer. However, from several animal studies it emerges that not all opioids induce the same immunosuppressive effects, and evaluating each opioid's profile is important for appropriate analgesic selection. Buprenorphine is a potent opioid that is frequently prescribed for chronic pain. Acute intracerebroventricular administration of buprenorphine has been shown in rats not to affect cellular immune responses, while a statistically significant inhibition of the immune response was observed with morphine. In mouse studies, chronic administration of buprenorphine led to immune parameters important for antimicrobial responses or for anti-tumour surveillance (lymphoproliferation, natural killer (NK)-lymphocyte activity, cytokine production, lymphocyte number) being unaffected. In contrast, levels of these immune markers were significantly reduced when the potent micro-agonist fentanyl was administered, but recovered after longer periods as tolerance developed. Because the intrinsic immunosuppressive activity varies between individual opioids, predicting the outcome on immunity can be difficult. To study this, the effects of morphine, fentanyl and buprenorphine on NK-lymphocyte activity depressed by experimental surgery were examined in rats. Treating animals immediately after surgery with equianalgesic doses of morphine and buprenorphine significantly reduced surgery-induced immunosuppression. However, buprenorphine reverted NK-lymphocyte activity to preoperative levels, while in morphine-treated rats NK-lymphocyte activity was ameliorated, although not completely. In contrast, fentanyl did not prevent immunosuppression induced by surgery. Overall, from several animal studies it emerges that buprenorphine has the more favourable profile, being a potent analgesic devoid of intrinsic immunosuppressive activity.
Do Functional Tests Predict Low Back Pain? (2000)

Some associations were found between the functional tests and future low back pain. The wide variation in the results questions the value of the tests in health examinations (e.g., in screening or surveillance of low back disorders).
Strained Tetragonal States and Bain Paths in Metals (1997)

Paths of tetragonal states between two phases of a material, such as bcc and fcc, are called Bain paths. Two simple Bain paths can be defined in terms of special imposed stresses, one of which applies directly to strained epitaxial films. Each path goes far into the range of nonlinear elasticity and reaches a range of structural parameters in which the structure is inherently unstable. In this Letter we identify and analyze the general properties of these paths by density functional theory. Special examples include vanadium, cobalt, and copper, and the epitaxial path is used to identify an epitaxial film as related uniquely to a bulk phase.
Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation (2015)

We identified and validated a specific T-cell polyfunctional response to CMV antigen stimulation that provides a clinically useful prediction of subsequent cytomegalovirus risk. This novel diagnostic approach could inform the optimal duration of individual prophylaxis.
Nutrition for the Eye: Different Susceptibility of the Retina and the Lacrimal Gland to Dietary Omega-6 and Omega-3 Polyunsaturated Fatty Acid Incorporation (2009)

The purpose of this study was to compare the susceptibility of the retina and the exorbital lacrimal gland to dietary supplies of long-chain omega-3 (omega3) and omega-6 (omega6) polyunsaturated fatty acids (LC-PUFAs). Male Wistar rats were fed a 5% lipid diet containing: (1) 10% eicosapentaenoic acid (EPA) and 7% docosahexaenoic acid (DHA), or (2) 10% gamma-linolenic acid (GLA), or (3) 10% EPA, 7% DHA and 10% GLA or (4) a balanced diet deprived of EPA, DHA and GLA for 3 months. Lipids were extracted from plasma phospholipids, retina and exorbital lacrimal gland, and fatty acid composition was determined by gas chromatography. Dietary supplementation with EPA and DHA increased omega3 PUFA levels in plasma phospholipids as well as in the retina and the exorbital lacrimal gland. By contrast, GLA supplementation favored omega6 PUFA incorporation, and particularly the incorporation of the end-chain omega6 product, docosapentaenoic acid (DPA), into all tissues. Supplementation with EPA, DHA and GLA increased the levels of DHA, EPA and dihomo-GLA (dGLA), whereas arachidonic acid (AA) was unchanged and DPA decreased in the retina and the lacrimal gland. The ability of both tissues to incorporate PUFAs from blood was evaluated. The results showed that the retina was more selective than the lacrimal gland for EPA. In spite of the different susceptibility of the retina and the lacrimal gland to dietary PUFAs, these results suggest that the concomitant use of dietary omega3 and omega6 PUFAs may be useful in modulating inflammation in both tissues.
Weil Sequences: A Family of Binary Sequences with Good Correlation Properties (2006)

We describe a family of binary sequences, called Weil sequences, which have prime length. The sequences are derived from the single quadratic-residue-based Legendre sequence using a "shift-and-add" construction. The Weil sequences have correlation sidelobes bounded by 2√p + 5, where p is the length. Thus they are asymptotically within a factor of two of the Welch bound. The sequences are optimally balanced when p is congruent to 3 modulo 4, and well-balanced otherwise. The family size is (p-1)/2