gebhart/patrepeval huggingface dataset:
Probabilistic fusion and analysis of multimodal image features (2017)

In this paper, an approach for identifying corresponding image features across different imaging modalities is presented. The method includes spatial alignment of sensor images on short and long distance as well as a probabilistic fusion approach for combining multiple unimodal to multimodal image features. An experimental statistical comparison of uni- and multimodal image features is performed using RGB, IR and thermal cameras. Therefore, the sensors are mounted on an Ackermann steering platform in a typical industrial environment. The multimodal features are examined regarding repetitive characteristics, quantity and spatial distribution.
Chemical and immunological properties of lipophorins from seven insect orders (1984)

Abstract The major insect hemolymph lipoprotein, lipophorin, was isolated from adults of eight insect species representing seven insect orders. Sodium dodecyl sulfate polyacrylamide gel electrophoresis was used to compare their respective apoprotein components. In all species examined lipophorin was composed of at least two apoproteins, apolipophorin I (M r ∼ 250,000) and apolipophorin II (M r ∼ 78,000), and two species had a third apoprotein, apolipophorin III (M r ∼ 17,000). The density of each isolated lipophorin was determined from the refractive index of KBr following density gradient centrifugation. Immunoblotting with anti‐larval Manduca sexta apolipophorin I and II of the apoproteins separated by SDS‐PACE indicated cross reactivity between anti‐ M sexta apoLp‐ll and apoLp‐ll in all species tested. Anti‐ M sexta apoLp‐l exhibited no cross reactivity for any species tested. Fluorescent lectin staining of the apoproteins separated on SDS‐PAGE gels revealed the presence of covalently bound carbohydrate residues.
Second- and Third-Order Signal Predistortion for Nonlinear Distortion Suppression in a TWT (2005)

The nonlinearity inherent in the traveling wave tube (TWT) amplifier distorts amplified signals and results in reduced efficiency and bandwidth, limiting its use in communication and electronic countermeasure applications. Signal predistortion is an effective technique for suppressing nonlinear distortion in TWTs that provides high suppression and requires simple circuits for implementation. While conventional predistortion linearizers are based on third-order intermodulation (3IM) injection, this paper proposes using second-order (second-harmonic) signal injection in predistortion circuits. A detailed experimental investigation and comparison of second-order versus third-order signal predistortion is presented. It is observed that both schemes result in suppression of up to 30 dB (55 dBc) for the 3IM distortion products. However, experimental results indicate that second-harmonic signal injection performs better than 3IM in suppressing higher order products. The paper also investigates spatial evolution of the wave spectrum along the TWT axis with and without injection, and sensitivity of the suppression to injected signals amplitude, phase and the fundamental frequency.
NETIVAR: NETwork Information Visualization based on Augmented Reality (2018)

Connecting network cables to network switches is a time-consuming and inefficient task, and requires extensive documentation and preparation beforehand to ensure no service faults are encountered by the users. In this paper, a new AR smartphone application that overlays network switch information over the user's vision is designed and developed for real working environment to increase user's efficiency in working with a network switch. Specifically, the prototype of the AR App is developed on the Android platform using both the Unity game engine and Vuforia AR library and connecting to the network switch to retrieve network information through telnet. By using the camera on the smartphone for capturing the visual information from the working environment, i.e. the network switch in this App, the network switch information such as speed, types, etc. will be overlaid on each port on the smartphone screen. A user study was conducted to evaluate the effectiveness of the AR App to assist users in performing network tasks. In particular, participants were tasked with connecting switchports to a patch panel to match up corresponding configurations. After three tests, it was found that the times for completion and mistakes made were reduced in the final test when compared to the first. This highlights the positive effects of the application in improving the user's efficiency.
Clostridium difficile Toxin Associated with Chronic Diarrhea and Failure to Gain Weight (1983)

Two young children are described in whom chronic diarrhea associated with the presence of Clostridium difficile toxin responded to treatment with oral vancomycin. C. difficile infection should be considered in the evaluation of young children with diarrhea who fail to gain weight, even in the absence of prior antibiotic treatment.
Radiation Effects on Membranes: III. The Effect of X Irradiation on Survival of Mammalian Cells Substituted by Polyunsaturated Fatty Acids (1982)

H. Wolters, A. W. T. Konings, Radiation Effects on Membranes: III. The Effect of X Irradiation on Survival of Mammalian Cells Substituted by Polyunsaturated Fatty Acids, Radiation Research, Vol. 92, No. 3 (Dec., 1982), pp. 474-482
Automating the deployment of 5G Network Slices using ONAP (2019)

Open Network Automation Platform (ONAP) is a carrier grade platform for automatically deploying and managing Virtualized Network Functions. In this paper, we address the deployment of network slices in order to come up with a model that is compatible with ONAP. We analyze various types of network slice ontology presented in the framework of 5G standardization bodies and we propose an ONAP-compatible model on the basis of which we illustrate the design, onboarding, instantiation and distribution of a network slice. We concretely define and deploy a network slice implementing a private and customized mobile core network. The achieved results not only make true NFV and 5G promises, notably those referring to on-demand networks, service customization and time-to-market acceleration, but they open the door to the deployment of private tailored cloud-native 5G networks.
ChemInform Abstract: PREPARATION OF 6‐(BROMOMETHYL)‐2,4‐PTERIDINEDIAMINE HYDROBROMIDE AND ITS USE IN IMPROVED SYNTHESES OF METHOTREXATE AND RELATED COMPOUNDS (1977)

Abstract Das durch Kondensation von 2,4,5,6‐Tetraamino‐pyrimidin mit 1,3‐Dihydroxy‐aceton hergestellte Pteridin (Ia) enthält 5% (Ib) sowie weniger als 1% der Verbindungen (IIa) und (IIb).
Toward Community Sensing (2008)

A great opportunity exists to fuse information from populations of privately-held sensors to create useful sensing applications. For example, GPS devices, embedded in cellphones and automobiles, might one day be employed as distributed networks of velocity sensors for traffic monitoring and routing. Unfortunately, privacy and resource considerations limit access to such data streams. We describe principles of community sensing that offer mechanisms for sharing data from privately held sensors. The methods take into account the likely availability of sensors, the context-sensitive value of sensor information, based on models of phenomena and demand, and sensor owners' preferences about privacy and resource usage. We present efficient and well-characterized approximations of optimal sensing policies. We provide details on key principles of community sensing and highlight their use within a case study for road traffic monitoring.
Aptamer-Modified Monolithic Capillary Chromatography for Protein Separation and Detection (2008)

A capillary chromatography technique was developed for the separation and detection of proteins, taking advantage of the specific affinity of aptamers and the porous property of the monolith. A biotinylated DNA aptamer targeting cytochrome c was successfully immobilized on a streptavidin-modified polymer monolithic capillary column. The aptamer, having a G-quartet structure, could bind to both cytochrome c and thrombin, enabling the separation of these proteins from each other and from the unretained proteins. Elution of strongly bound proteins was achieved by increasing the ionic strength of the mobile phase. The following proteins were tested using the aptamer affinity monolithic columns: human immunoglobulin G (IgG), hemoglobin, transferrin, human serum albumin, cytochrome c, and thrombin. Determination of cytochrome c and thrombin spiked into dilute serum samples showed no interference from the serum matrix. The benefit of porous properties of the affinity monolithic column was demonstrated by selective capture and preconcentration of thrombin at low ionic strength and subsequent rapid elution at high ionic strength. The combination of the polymer monolithic column and the aptamer affinities makes the aptamer-modified monolithic columns useful for protein detection and separation.
Systemic Antifungal Agents Against AIDS-Related Opportunistic Infections: Current Status and Emerging Drugs in Development (1999)

No effective drug was available for the treatment of systemic fungal infections until the discovery of Amphotericin B in 1953. Since then flucytosine, azoles and later the triazoles, have now become available. The current interest in the development of new antifungal agents can partially be explained by the dramatic rise in the number of AIDS cases and the subsequent suppression of the immune system in patients with the disease. For example, over 90% of those diagnosed to be HIV-positive contract a fungal infection during the course of their illness. Other conditions that have spurred the development of new systemic antifungal agents include the increase in the frequency of bone marrow and organ transplants, the use of antineoplastic agents, long-term use of corticosteroids and even the indiscriminate use of antibiotics. The emergence of fungi resistant to currently available agents, especially the azoles, has made the need for new and effective antifungal agents more urgent. This review article focuses on agents targeted against opportunistic fungal infections, i.e., fungal infections which, in contrast to immunocompetent individuals, may cause serious life-threatening illness in immunocompromised individuals. Agents currently on the market or undergoing clinical development, as well as potential new agents that have been discovered, are discussed.
Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions (2019)

In the CNS, perivascular cells ("pericytes") associate with endothelial cells to mediate the formation of tight junctions essential to the function of the blood-brain barrier (BBB). The BBB protects the CNS by regulating the flow of nutrients and toxins into and out of the brain. BBB dysfunction has been implicated in the progression of Alzheimer's disease (AD), but the role of pericytes in BBB dysfunction in AD is not well understood. In the developing embryo, CNS pericytes originate from two sources: mesoderm and neural crest. In this study, we report two protocols using mesoderm or neural crest intermediates, to generate brain-specific pericyte-like cells from induced pluripotent stem cell (iPSC) lines created from healthy and AD patients. iPSC-derived pericytes display stable expression of pericyte surface markers and brain-specific genes and are functionally capable of increasing vascular tube formation and endothelial barrier properties.
Pachinko allocation: dag-structured mixture models of topic correlations (2007)

Statistical topic models are increasingly popular tools for summarization and manifold discovery in discrete data. However, the majority of existing approaches capture no or limited correlations between topics. We propose the pachinko allocation model (PAM), which captures arbitrary, nested, and possibly sparse correlations between topics using a directed acyclic graph (DAG). We present various structures within this framework, different parameterizations of topic distributions, and an extension to capture dynamic patterns of topic correlations. We also introduce a non-parametric Bayesian prior to automatically learn the topic structure from data. The model is evaluated on document classification, likelihood of held-out data, the ability to support fine-grained topics, and topical keyword coherence. With a highly-scalable approximation, PAM has also been applied to discover topic hierarchies in very large datasets.
Accelerating Cloud Storage System with Byte-Addressable Non-Volatile Memory (2015)

As building block for cloud storage, distributed file system uses underlying local file systems to manage objects. However, the underlying file system, which is limited by metadata and journaling I/O, significantly affects the performance of the distributed file system. This paper presents an NVM-based file system (referred to as NV-Booster) to accelerate object access for storage node. The NV-Booster leverages byte-addressability and persistency of nonvolatile memory (NVM) to speedup metadata accesses and file system journaling. With NV-Booster, metadata is kept in NVM and accessed in byte-addressable manner through memory bus, while object is stored on hard disk and accessed from I/O bus. In addition, proposed NV-Booster enables fast object search and mapping between object ID and on-disk location with an efficient in-memory namespace management. NV-Booster is implemented in kernel space with NVDIMM and has been extensively evaluated under various workloads. Our experiments show that NV-Booster improves Ceph performance up to 10X, compared to the Ceph with existing local file systems.
Heterogeneous CLICK reactions for biological conjugations (2009)

Common CLICK reactions, often used in labeling, require ascorbic acid and organic solvents. For wider opportunity and usage in biological conjugations, CLICK reactions were performed with zinc amalgam instead of the acid. This allows for CLICK reactions to take place in virtually aqueous solutions. A simple bench-top method was created using columns of anion or cation exchange resins loaded with a copper II bathophenanthroline or copper II phendione solution, potassium phosphate buffer, and zinc amalgam. A mixture of coumarin and glycine are run through the columns and the product collected without any purification process needed. Coumarin dye was found to provide proof of a successful CLICK when the product lit up blue under UV light. High Performance Liquid Chromatography (HPLC) showed the coumarin peak in a control reaction and UV-vis indicated where the product peak should occur.
A novel compilation approach for image processing graphs on a many-core platform with explicitly managed memory (2013)

Explicitly managed memory many-cores (EMM) have been a part of the industrial landscape for the last decade. The IBM CELL processor, general-purpose graphics processing units (GP-GPU) and the STHORM embedded many-core of STMicroelectronics are representative examples. This class of architecture is expected to scale well and to deliver good performance per watt and per mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of silicon. As such, it is appealing for application problems with regular data access patterns. However, this moves significant complexity to the programmer who must master parallelization and data movement. High level programming tools are therefore essential in order to allow the effective programming of EMM many-cores to a wide class of programmers. This paper presents a novel approach designed for simplifying the programming of EMM many-core architectures. It initially addresses the image processing application domain and has been targeted to the STHORM platform. It takes a high-level description of the computation kernel algorithm and generates an OpenCL kernel optimized for the target architecture, while managing the parallelization and data movements across the hierarchy in a transparent fashion. The goal is to provide both high productivity and high performance without requiring parallel computing expertise from the programmer, nor the need for application code specialization for the target architecture.
Full-Band Matching of Waveguide Discontinuities (2005)

Almost all waveguide components consist of transitions, either continuous or discontinuous, because they are either of modified structure or filled with some material. Such transitions vary from simple types, such as transitions from one waveguide to another (like a flange coupling, E- or H-plane shift, E- or H-plane bend, twist, window, or in-guide detector), to more complicated types, where a change in mode also occurs, as in transitions from rectangular to circular or square waveguide, coaxial or strip line, etc. Another example of this latter more complicated type is the Magic Tee.
Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives (2017)

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) with a unique morphological appearance, associated coagulopathy and canonical balanced translocation of genetic material between chromosomes 15 and 17. APL was first described as a distinct subtype of AML in 1957 by Dr Leif Hillestad who recognized the pattern of an acute leukemia associated with fibrinolysis, hypofibrinogenemia and catastrophic hemorrhage. In the intervening years, the characteristic morphology of APL has been described fully with both classical hypergranular and variant microgranular forms. Both are characterized by a balanced translocation between the long arms of chromosomes 15 and 17, [t(15;17)(q24;q21)], giving rise to a unique fusion gene <i>PML-RARA</i> and an abnormal chimeric transcription factor (PML-RARA), which disrupts normal myeloid differentiation programs. The success of current treatments for APL is in marked contrast to the vast majority of patients with non-promyelocytic AML. The overall prognosis in non-promyelocytic AML is poor, and although there has been an improvement in overall survival in patients aged <60 years, only 30%-40% of younger patients are still alive 5 years after diagnosis. APL therapy has diverged from standard AML therapy through the empirical discovery of two agents that directly target the molecular basis of the disease. The evolution of treatment over the last 4 decades to include all-<i>trans</i> retinoic acid and arsenic trioxide, with chemotherapy limited to patients with high-risk disease, has led to complete remission in 90%-100% of patients in trials and rates of overall survival between 86% and 97%.
Uncertainty analysis of diffuse-gray radiation enclosure problems: A hypersensitive case study (1993)

An uncertainty analysis of diffuse-gray enclosure problems is presented. The genesis was a diffuse-gray enclosure problem which proved to be hypersensitive to the specification of view factors. This genesis is discussed in some detail. The uncertainty analysis is presented for the general diffuse-gray enclosure problem and applied to the hypersensitive case study. It was found that the hypersensitivity could be greatly reduced by enforcing both closure and reciprocity for the view factors. The effects of uncertainties in the surface emissivities and temperatures are also investigated.
Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase (2018)

The rise of antibiotic resistance has created a mounting crisis across the globe and an unmet medical need for new antibiotics. As part of our efforts to develop new antibiotics to target the uncharted surface bacterial transglycosylase, we report an affinity-based ligand screen method using penicillin-binding proteins immobilized on beads to selectively isolate the binders from complex natural products. In combination with mass spectrometry and assays with moenomycin A and salicylanilide analogues (1-10) as reference inhibitors, we isolated four potent antibacterials confirmed to be benastatin derivatives (11-13) and albofungin (14). Compounds 11 and 14 were effective antibiotics against a broad-spectrum of Gram-positive and Gram-negative bacteria, including Acinetobacter baumannii, Clostridium difficile, Staphylococcus aureus, and drug-resistant strains with minimum inhibitory concentrations in the submicromolar to nanomolar range.
Mobile Data Offloading: How Much Can WiFi Deliver? (2012)

This paper presents a quantitative study on the performance of 3G mobile data offloading through WiFi networks. We recruited 97 iPhone users from metropolitan areas and collected statistics on their WiFi connectivity during a two-and-a-half-week period in February 2010. Our trace-driven simulation using the acquired whole-day traces indicates that WiFi already offloads about 65% of the total mobile data traffic and saves 55% of battery power without using any delayed transmission. If data transfers can be delayed with some deadline until users enter a WiFi zone, substantial gains can be achieved only when the deadline is fairly larger than tens of minutes. With 100-s delays, the achievable gain is less than only 2%-3%, whereas with 1 h or longer deadlines, traffic and energy saving gains increase beyond 29% and 20%, respectively. These results are in contrast to the substantial gain (20%-33%) reported by the existing work even for 100-s delayed transmission using traces taken from transit buses or war-driving. In addition, a distribution model-based simulator and a theoretical framework that enable analytical studies of the average performance of offloading are proposed. These tools are useful for network providers to obtain a rough estimate on the average performance of offloading for a given WiFi deployment condition.
Improved Recovery and Identification of Membrane Proteins from Rat Hepatic Cells using a Centrifugal Proteomic Reactor (2011)

Despite their importance in many biological processes, membrane proteins are underrepresented in proteomic analysis because of their poor solubility (hydrophobicity) and often low abundance. We describe a novel approach for the identification of plasma membrane proteins and intracellular microsomal proteins that combines membrane fractionation, a centrifugal proteomic reactor for streamlined protein extraction, protein digestion and fractionation by centrifugation, and high performance liquid chromatography-electrospray ionization-tandem MS. The performance of this approach was illustrated for the study of the proteome of ER and Golgi microsomal membranes in rat hepatic cells. The centrifugal proteomic reactor identified 945 plasma membrane proteins and 955 microsomal membrane proteins, of which 63 and 47% were predicted as bona fide membrane proteins, respectively. Among these proteins, >800 proteins were undetectable by the conventional in-gel digestion approach. The majority of the membrane proteins only identified by the centrifugal proteomic reactor were proteins with ≥ 2 transmembrane segments or proteins with high molecular mass (e.g. >150 kDa) and hydrophobicity. The improved proteomic reactor allowed the detection of a group of endocytic and/or signaling receptor proteins on the plasma membrane, as well as apolipoproteins and glycerolipid synthesis enzymes that play a role in the assembly and secretion of apolipoprotein B100-containing very low density lipoproteins. Thus, the centrifugal proteomic reactor offers a new analytical tool for structure and function studies of membrane proteins involved in lipid and lipoprotein metabolism.