gebhart/patrepeval huggingface dataset:
Growth of SiO <sub>2</sub> at Room Temperature with the Use of Catalyzed Sequential Half-Reactions (1997)

Films of silicon dioxide (SiO2) were deposited at room temperature by means of catalyzed binary reaction sequence chemistry. The binary reaction SiCl4 + 2H2O --> SiO2 + 4HCl was separated into SiCl4 and H2O half-reactions, and the half-reactions were then performed in an ABAB ellipsis sequence and catalyzed with pyridine. The pyridine catalyst lowered the deposition temperature from >600 to 300 kelvin and reduced the reactant flux required for complete reactions from approximately 10(9) to approximately 10(4) Langmuirs. Growth rates of approximately 2.1 angstroms per AB reaction cycle were obtained at room temperature for reactant pressures of 15 millitorr and 60-second exposure times with 200 millitorr of pyridine. This catalytic technique may be general and should facilitate the chemical vapor deposition of other oxide and nitride materials.
Multipath communications using a phase-conjugate array (2003)

A new microwave wireless communications scheme based on a phase-conjugating retrodirective antenna is introduced for maintaining a reliable radio link in a severe multipath environment. The method does not eliminate multipath, but uses it advantageously and is better suited to cope with mobile receivers than other methods. In the ideal case, the negative effects of multipath propagation can be completely avoided and multipath propagation only improves reliability of the radio channel. The principle is experimentally verified at 5.35 GHz and demonstrates that severe fading can be avoided and variation of received signal power can be reduced.
Design and Operational Aspects of Gas and Steam Turbines for the Novel Solar Hybrid Combined Cycle SHCC® (2010)

Solar hybrid power plants are characterized by a combination of heat input both of high temperature solar heat and heat from combustion of gaseous or liquid fuel which enables to supply the electricity market according to its requirements and to utilize the limited and high grade natural resources economically. The SHCC® power plant concept integrates the high temperature solar heat into the gas turbine process and in addition — depending on the scheme of the process cycle — downstream into the steam cycle. The feed-in of solar heat into the gas turbine is carried out between compressor outlet and combustor inlet either by direct solar thermal heating of the pressurized air inside the receivers of the solar tower or by indirectly heating via interconnection of a heat transfer fluid. Thus, high shares of solar heat input referring to the total heat input of more than 60% in design point can be achieved. Besides low consumption of fossil fuels and high efficiency, the SHCC® concept is aimed for a permanent availability of the power plant capacity due to the possible substitution of solar heat by combustion heat during periods without sufficient solar irradiation. In consequence, no additional standby capacity is necessary. SHCC® can be conducted with today’s power plant and solar technology. One of the possible variants has already been demonstrated in the test field PSA in Spain using a small capacity gas turbine with location in the head of the solar tower for direct heating of the combustion air. However, the authors present and analyze also alternative concepts for power plants of higher capacity. Of course, the gas turbine needs a design which enables the external heating of the combustion air. Today only a few types of gas turbines are available for SHCC® demonstration. But these gas turbines were not designed for solar hybrid application at all. Thus, the autors present finally some reflections on gas turbine parameters and their consequences for SHCC® as basis for evaluation of potentials of SHCC®.
Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: Drug-discovery strategies (2009)

Medicinal chemistry has produced small-molecule agents with drug-like character that potently and safely modulate the activity of discrete endocannabinoid system components as potential treatments for medical disorders, including various psychiatric conditions. Two cannabinoid (CB) receptors (CB1 and CB2) currently represent prime endocannabinoid-system therapeutic targets for ligands that either mimic endocannabinoid signalling processes and/or potentiate endocannabinoid-system activity (agonists) or attenuate pathologically heightened endocannabinoid-system transmission (antagonists). Two endocannabinoid deactivating enzymes, fatty acid amide hydrolase (FAAH) and soluble monoacylglycerol lipase (MGL), are increasingly prominent targets for inhibitors that indirectly potentiate endocannabinoid-system signalling. Continued profiling of drug candidates in relevant disease models, identification of additional cannabinoid-related therapeutic targets, and validation of new pharmacological modes of endocannabinoid system modulation will undoubtedly invite further translational efforts in the cannabinoid field for treating psychiatric disorders and other medical conditions.
Solving constrained quadratic binary problems via quantum adiabatic evolution (2016)

Quantum adiabatic evolution is perceived as useful for binary quadratic programming problems that are a priori unconstrained. For constrained problems, it is a common practice to relax linear equality constraints as penalty terms in the objective function. However, there has not yet been proposed a method for efficiently dealing with inequality constraints using the quantum adiabatic approach. In this paper, we give a method for solving the Lagrangian dual of a binary quadratic programming (BQP) problem in the presence of inequality constraints and employ this procedure within a branch-and-bound framework for constrained BQP (CBQP) problems.
MEMS loop heat pipe based on coherent porous silicon technology (2002)

This paper discusses the theory, modeling, design, fabrication and preliminary test results of the MEMS loop heat pipe being developed at the Center for Microelectronic Sensors and MEMS at the University of Cincinnati. The emphasis is placed upon the silicon micro wick and its production through a novel technique known as Coherent Porous Silicon (CPS) Technology.
Quantitative protein determination for CYP induction via LC‐MS/MS (2010)

The Cytochrome P450 (CYP) proteins are a family of membrane bound proteins that function as a major metabolizing enzyme in the human body. Quantification of CYP induction is critical in determining the disposition, safety and efficacy of drugs in humans. Described is a gel-free, high-throughput LC-MS approach to quantitate the CYP isoforms 1A2, 2B6, 3A4 and 3A5 by measuring isoform specific peptides released by enzymatic digestion of the hepatocyte incubations. The method uses synthetic stable isotope-labeled peptides as internal standards and allows both relative and absolute quantification to be performed from hepatic microsomal preparations. CYP protein determined by this LC-MS method correlated well with the mRNA and activity for induced levels of CYP1A2, CYP2B6 and CYP3A4. Interestingly, a small fold change was observed for the induction of 3A5 with phenobarbital. The results were reproducible with an average CV less then 10% for repeat analysis of the sample. This LC-MS method offers a robust assay for CYP protein quantitation for use in CYP induction assays.
Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration (1991)

The leukocyte adhesion molecule-1 (LAM-1, TQ=1, Leu-8) in humans, like its murine homologue, MEL-14, is the principal receptor that mediates the binding of leukocytes to high endothelial venules (HEV) of peripheral lymph nodes. In this study, several regions of the protein which mediate receptor function were identified by using a large panel of murine mAb reactive with LAM-1. Individual mAb reacted with LAM-1+ cells with characteristic intensities of immunofluorescence staining, and each bound both lymphocytes and neutrophils. Lymphocyte attachment to HEV was significantly inhibited by the binding of five mAb. In contrast, only two of these mAb were able to completely block the binding of phosphomannan monoester core complex from the yeast Hansenula holstii cell wall (PPME), a phosphomannan monoester core polysaccharide that serves as a soluble model of the natural ligand of LAM-1. Interestingly, the binding of two anti-LAM-1 mAb to cells induced a significant increase in PPME binding, reminiscent of the increase in receptor affinity observed after leukocyte activation. Antibody cross-blocking studies indicated that many of the functionally important epitopes were spatially distinct, and domain mapping indicated that they recognized distinct domains of LAM-1. The expression and function of these epitopes were further assessed by using a variety of animal species to further characterize the functionally relevant epitopes defined in these studies. At least some anti-LAM-1 mAb reacted with leukocytes from monkey, cow, rabbit, sheep, dog, cat, pig, and goat, but not from chicken, rat, or mouse. The reactivity of anti-LAM-1 mAb in several animal species correlated with the ability of leukocytes to bind PPME, and mAb that inhibited lymphocyte binding to HEV in man could also inhibit this function in rhesus monkey and dog. Thus, several LAM-1 epitopes are structurally and functionally well conserved throughout recent mammalian evolution, emphasizing an important role for LAM-1 in the regulation of leukocyte traffic.
Transdermal nicotine for Tourette's syndrome (1996)

The present review evaulates the therapeutic response to the transdermal nicotine patch (TNP) in Tourette's syndrome (TS) patients. Twenty TS patients (17 children and adolescents, 3 adults), in 18 of whom tic symptoms were not controlled with neuroleptics and 2 of whom were free of medication, were followed for various lenghts of time following the application of two TPs (each 7mg/24 hours). While there was a broad range in individual response, it was determined that each application of a single TNP produced a significant reduction in Yale Global Tic Severity Scale mean scores for an average duration of approximately 1 to 2 weeks post-application. Individual case reports are discusssed as well as the possible therapeutic mechanisms of transdermal nicotine in reducing the symptoms of TS. Although our data should be viewed as preliminary until controlled studies are completed, the present open-trial findings suggest that transdermal nicotine is an effective adjunct to neuroleptic theraphy of TS. Drug Dev. Res. 38:290–298. © 1996 Wiley-Liss, Inc.
Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues (1989)

Structure-activity investigation in the series of acyclic nucleotide analogs bearing a modified phosphoric acid residue at the side-chain revealed two novel classes of antivirals: N--(3-hydroxy-2-phosphonylmethoxypropyl)- (HPMP-) and N-(2-phosphonylmethoxyethyl) (PME-) derivatives of heterocyclic bases. Adenine, guanine, 2-aminoadenine and (in the HPMP-series) cytosine derivatives act specifically against DNA viruses (herpes viruses,adenoviruses,poxviruses). The PME-compounds are also active against retroviruses (MSV,HIV)and exhibit a cytostatic effect on L-1210 mouse leukemia cells.The drugs are converted by the action of cellular nucleotide kinases into their diphosphates and inhibit viral and, to a lesser extent, cellular DNA synthesis. These metabolites exert a comparatively low inhibitory effect on viral (HSV-1) DNA polymerase. The diphosphates derived from PME-compounds strongly inhibit viral (HSV-1) ribonucleotide reductase and AMV reverse transcriptase.
A non-uniform cache architecture for low power system design (2005)

This paper proposes a non-uniform cache architecture for reducing the power consumption of memory systems. The non-uniform cache allows having different associativity values (i.e., the number of cache-ways) for different cache-sets. An algorithm determines the optimum number of cache-ways for each cache-set and generates object code suitable for the non-uniform cache memory. The paper also proposes a compiler technique for reducing redundant cache-way accesses and cache-tag accesses. Experiments demonstrate that our technique can reduce the power consumption of memory systems by up to 76% compared to the best result achieved by the conventional method
Mapping and Removing the Ventricular Far Field Component in Unipolar Atrial Electrograms (2020)

Application of our novel, simple and computationally inexpensive methods allows immediate diagnostic assessment of uEGM data without prolonging data acquisition.
Lymphadenopathy associated virus and its etiological role in AIDS. (1984)

Lymphadenopathy associated virus (LAV) is a novel human retrovirus first reported in 1983. It was isolated from the lymph node lymphocytes of a French homosexual patient with generalized hyperplasic lymphadenopathy. Subsequently LAV was isolated from patients with frank acquired immune deficiency syndrome (AIDS) coming from all the different high-risk groups, while anti-LAV antibodies were detected equally in individuals from all "at-risk" groups. Such a profile is consistent with the virus being the major etiological agent of AIDS. Furthermore its biological properties, namely its cytopathic effect in vitro, its T4-cell tropism as well as the role of the T4 molecule in virus infection explain, at least in part, the pathophysiology of AIDS. The major core (gag) proteins are p18, p25, and p13 which are products of a Pr55 precursor. The major envelope (env) glycoprotein is unusually large (gp110) for a retrovirus and comparable to those of the lentiviruses. Recently the virus has been molecularly cloned. The genome is 9.2 kb long, longer than any other known replication competent retrovirus apart from the lentiviruses. The absence of molecular hybridization between cloned LAV and human T-cell leukemia/lymphoma virus (HTLV) genomes compounds the original and extensive differences noted between these viruses and demonstrates that LAV is a prototype of a new class of human retrovirus.
Constricted Tube System for Presumptive Identification and Differentiation of Group D Streptococci (1979)

A single, constricted tube containing two differential media to identify and differentiate group D streptococci was developed. Test results with a limited number of group D streptococcal isolates were in complete agreement with results of conventional procedures.
Map-based cloning of the Hd1 gene controlling photoperiod sensitivity in rice. (2003)

A major quantitative trait locus, Hd1, that controls response to photoperiod was identified by the use of a map-based cloning strategy. High-resolution mapping using 1,505 segregants permitted the definition of a genomic region of about 12 kb as a candidate for Hd1. Further analysis revealed that Hd1 is a homologue of CONSTANS in Arabidopsis and encodes a protein with the structure of a zinc finger domain and a nuclear localization signal. Sequencing analysis revealed a 43-bp deletion in the first exon of photoperiod-sensitivity (se1) mutant HS66 and a 433-bp insertion in the intron in mutant HS110. Structural analysis confirmed that the major gene controlling response to photoperiod, Se1, was allelic to Hd1. Genetic complementation analysis confirmed the function of the candidate gene. The level of Hd1 mRNA was not greatly affected by a change in daylength. The findings suggest that Hd1 promotes heading under short-day conditions and delays heading under long-day conditions.
Enhancing Low‐Grade Thermal Energy Recovery in a Thermally Regenerative Ammonia Battery Using Elevated Temperatures (2015)

A thermally regenerative ammonia battery (TRAB) is a new approach for converting low-grade thermal energy into electricity by using an ammonia electrolyte and copper electrodes. TRAB operation at 72 °C produced a power density of 236 ± 8 Wm(-2), with a linear decrease in power to 95 ± 5 Wm(-2) at 23 °C. The improved power at higher temperatures was due to reduced electrode overpotentials and more favorable thermodynamics for the anode reaction (copper oxidation). The energy density varied with temperature and discharge rates, with a maximum of 650 Wh m(-3) at a discharge energy efficiency of 54% and a temperature of 37 °C. The energy efficiency calculated with chemical process simulation software indicated a Carnot-based efficiency of up to 13% and an overall thermal energy recovery of 0.5%. It should be possible to substantially improve these energy recoveries through optimization of electrolyte concentrations and by using improved ion-selective membranes and energy recovery systems such as heat exchangers.
Concurrent round-robin dispatching scheme in a clos-network switch (2005)

A Clos-network switch architecture is attractive because of its scalability. Previously proposed implementable dispatching schemes from the first stage to the second stage, such as random dispatching, are not able to achieve a high throughput unless the internal bandwidth is expanded. This paper proposes a concurrent round-robin dispatching (CRRD) scheme for a Clos-network switch, to overcome the throughput limitation of the random dispatching scheme. The CRRD scheme provides high switch throughput without expanding internal bandwidth. CRRD implementation is very simple because only simple roundrobin arbiters are adopted. In CRRD, the round-robin arbiters concurrently perform the matching between requesting cells and output links in each first-stage module to dispatch the cells to available second-stage modules. We show that CRRD achieves 100% throughput under uniform traffic. When the offered load reaches 1.0, the pointers of roundrobin arbiters at the first-stage and second-stage modules are effectively desynchronized and contention is avoided. key words: Packet switch, Clos-network switch, dispatching, arbitration, throughput
Refining LNA safety profile by controlling phosphorothioate stereochemistry (2020)

Drug discovery with phosphorothioate oligonucleotides is an area of intensive research. In this study we have controlled the stereochemistry of the phosphorothioate backbone of LNA oligonucleotides to investigate the differences in safety profile, target mRNA knock down, and cellular uptake in vitro. The study reveals that controlling only four stereocenters in an isomeric phosphorothioate mixture can improve the therapeutic index significantly by improving safety without compromising activity.
Two-dimensional phased arrays for application in surgery: Scanning by several focuses (2000)

Numerical simulation and comparative analysis of acoustic fields formed by two-dimensional phased arrays designed for ultrasonic surgery are conducted for the case of scanning by several focuses (in particular, by nine focuses arranged in a line and also by an array of nine focuses forming a 3×3 square grid). Calculations are performed for arrays with elements positioned at the surface both regularly (in square, ring, or hexagonal patterns) and randomly. Criteria for evaluating the “quality” of the intensity distributions in the field formed by the array in the case of scanning by several focuses are proposed. The quality of the intensity distributions for arrays containing 255 and 256 elements 5 mm in diameter arranged in regular patterns on the array’s surface (in square, ring, or hexagonal patterns) is inferior to that for arrays containing 256 randomly positioned elements. Among the regular arrays, the highest quality of intensity distributions is obtained for ring arrays, and the lowest quality is obtained for arrays with elements arranged in square or hexagonal patterns. The irregularity in the element positioning the array’s surface improves the quality of intensity distributions by reducing the secondary intensity peaks in the field formed by the array and, primarily, in the focal plane.
Novel System for Potential Nondestructive Material Inspection Using Positron Annihilation Lifetime Spectroscopy (2011)

A new positron annihilation lifetime spectrometer consisting of a start γ-ray detector, a stop γ-ray detector, a digital oscilloscope, and a positron detector, which is a plastic scintillator coupled to a photomultiplier tube, is described. A 22 Na source is placed between the positron detector and a sample to be studied. γ-ray signals related to positrons annihilating in the positron detector are rejected by anti-coincidence processing. Comparison of the positron lifetime spectrum of a steel strip collected with the new system with that collected with a conventional system using two specimens sandwiching the 22 Na source shows that accurate positron lifetime measurements are possible with the new system. The new system does not require cutting of the samples and is potentially applicable to truly nondestructive onsite inspection of various materials such as those used in nuclear power plants, aircraft and cars, etc., by positron annihilation lifetime spectroscopy (PALS).
Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica (2019)

Neuromyelitis optica (NMO) is an autoimmune CNS disorder mediated by pathogenic aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG). Although AQP4-IgG-driven complement-dependent cytotoxicity (CDC) is critical for the formation of NMO lesions, the molecular mechanisms governing optimal classical pathway activation are unknown. We investigated the molecular determinants driving CDC in NMO using recombinant AQP4-specific autoantibodies (AQP4 rAbs) derived from affected patients. We identified a group of AQP4 rAbs targeting a distinct extracellular loop C epitope that demonstrated enhanced CDC on target cells. Targeted mutations of AQP4 rAb Fc domains that enhance or diminish C1q binding or antibody Fc-Fc interactions showed that optimal CDC was driven by the assembly of multimeric rAb platforms that increase multivalent C1q binding and facilitate C1q activation. A peptide that blocks antibody Fc-Fc interaction inhibited CDC induced by AQP4 rAbs and polyclonal NMO patient sera. Super-resolution microscopy revealed that AQP4 rAbs with enhanced CDC preferentially formed organized clusters on supramolecular AQP4 orthogonal arrays, linking epitope-dependent multimeric assembly with enhanced C1q binding and activation. The resulting model of AQP4-IgG CDC provides a framework for understanding classical complement activation in human autoantibody-mediated disorders and identifies a potential new therapeutic avenue for treating NMO.
Paddle‐based rotating‐shield brachytherapy (2015)

P-RSBT produces treatment plans that are dosimetrically and temporally superior to those of S-RSBT and D-RSBT, although P-RSBT systems may be more mechanically challenging to develop than S-RSBT or D-RSBT. A P-RSBT implementation with 4-6 shield paddles would be sufficient to outperform S-RSBT and D-RSBT if delivery times are constrained to less than 15 min/fx.
Caloxin: a novel plasma membrane Ca<sup>2+</sup>pump inhibitor (2001)

Plasma membrane (PM) Ca2+ pump is a Ca+-Mg2+-ATPase that expels Ca2+ from cells to help them maintain low concentrations of cytosolic Ca2+ . There are no known extracellularly acting PM Ca2+ pump inhibitors, as digoxin and ouabain are for Na+ pump. In analogy with digoxin, we define caloxins as extracellular PM Ca2+ pump inhibitors and describe caloxin 2A1. Caloxin 2A1 is a peptide obtained by screening a random peptide phage display library for binding to the second extracellular domain (residues 401-413) sequence of PM Ca2+ pump isoform 1b. Caloxin 2A1 inhibits Ca2+-Mg2+-ATPase in human erythrocyte leaky ghosts, but it does not affect basal Mg2+-ATPase or Na+-K+-ATPase in the ghosts or Ca2+-Mg2+-ATPase in the skeletal muscle sarcoplasmic reticulum. Caloxin 2A1 also inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate, which is a partial reaction of this enzyme. Consistent with inhibition of the PM Ca2+ pump in vascular endothelium, caloxin 2A1 produces an endothelium-dependent relaxation that is reversed by N(G)-nitro-L-arginine methyl ester. Thus caloxin 2A1 is a novel PM Ca2+ pump inhibitor selected for binding to an extracellular domain.