gebhart/patrepeval huggingface dataset:
Lysates of a Probiotic, Lactobacillus rhamnosus, Can Improve Skin Barrier Function in a Reconstructed Human Epidermis Model (2019)

The main function of the skin is to protect the body from the external environment. The barrier function of the skin is mainly provided by the stratum corneum, which consists of corneocytes bound with the corneodesmosomes and lamellar lipids. Skin barrier proteins like loricrin and filaggrin also contribute to the skin barrier function. In various skin diseases, skin barrier dysfunction is a common symptom, and skin irritants like detergents or surfactants could also perturb skin barrier function. Many efforts have been made to develop strategies to improve skin barrier function. Here, we investigated whether the microfluidized lysates of <i>Lactobacillus rhamnosus</i> (LR), one of the most widely used probiotic species for various health benefits, may improve the skin barrier function in a reconstructed human epidermis, Keraskin™. Application of LR lysate on Keraskin™ increased the expression of tight junction proteins; claudin 1 and occludin as determined by immunofluorescence analysis, and skin barrier proteins; loricrin and filaggrin as determined by immunohistochemistry and immunofluorescence analysis and qPCR. Also, the cytotoxicity of a skin irritant, sodium lauryl sulfate (SLS), was alleviated by the pretreatment of LR lysate. The skin barrier protective effects of LR lysate could be further demonstrated by the attenuation of SLS-enhanced dye-penetration. LR lysate also attenuated the destruction of desmosomes after SLS treatment. Collectively, we demonstrated that LR lysate has protective effects on the skin barrier, which could expand the utility of probiotics to skin-moisturization ingredients.
Aliphatic Diazirines as Photoaffinity Probes for Proteins: Recent Developments (2011)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTAliphatic Diazirines as Photoaffinity Probes for Proteins: Recent DevelopmentsJoydip Das*View Author Information Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204, United StatesTel: 713-743-1708. Fax: 713-743-1884. E-mail: [email protected]Cite this: Chem. Rev. 2011, 111, 8, 4405–4417Publication Date (Web):April 5, 2011Publication History Received19 August 2010Published online5 April 2011Published inissue 10 August 2011https://doi.org/10.1021/cr1002722Copyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views8673Altmetric-Citations200LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (2 MB) Get e-AlertscloseSUBJECTS:Ions,Labeling,Monomers,Peptides and proteins,Receptors Get e-Alerts
Growth, microstructure, and luminescent properties of direct-bandgap InAlP on relaxed InGaAs on GaAs substrates (2013)

Direct-bandgap InAlP alloy has the potential to be an active material in nitride-free yellow-green and amber optoelectronics with applications in solid-state lighting, display devices, and multi-junction solar cells. We report on the growth of high-quality direct-bandgap InAlP on relaxed InGaAs graded buffers with low threading dislocation densities. Structural characterization reveals phase-separated microstructures in these films which have an impact on the luminescence spectrum. While similar to InGaP in many ways, the greater tendency for phase separation in InAlP leads to the simultaneous occurrence of compositional inhomogeneity and CuPt-B ordering. Mechanisms connecting these two structural parameters are presented as well as results on the effect of silicon and zinc dopants on homogenizing the microstructure. Spontaneous formation of tilted planes of phase-separated material, with alternating degrees of ordering, is observed when InAlP is grown on vicinal substrates. The photoluminescence peak-widths of these films are actually narrower than those grown on exact (001) substrates. We find that, despite phase-separation, ordered direct-bandgap InAlP is a suitable material for optoelectronics.
<i>Thermoflavimicrobium</i> (2015)

Abstract Ther'mo.fla.vi.mi.cro'bi.um. Gr. adj. thermos hot; L. adj. flavus yellow; Gr. adj. mikros small; Gr. n. bios life; N.L. neut. n. Thermoflavimicrobium a thermophilic yellow‐colored microbe. Aerobic, Gram‐stain‐positive, non‐acid‐fast chemo‐organotroph. Aerial and substrate mycelia are formed. Aerial mycelium is abundant and yellow. Sessile endospores are produced on dichotomously branched sporophores. Thermophilic . Growth occurs at 55°C but not at 30°C. The wall peptidoglycan contains meso ‐diaminopimelic acid but no characteristic sugars. Predominant menaquinone is MK‐7. Major fatty acids are C 15:0 iso , C 15:0 ante , and C 16:0 iso . The phylogenetically nearest neighbor is the genus Planofilum . DNA G + C content ( mol %): 43. Type species : Thermoflavimicrobium dichotomicum (Krasil' nikov and Agre, 1964) Yoon, Kim, Shin and Park 2005, 399 VP ( Actinobifida dichotomica Krasil'nikov and Agre 1964, 939; Thermoactinomyces dichotomicus corrig. Cross and Goodfellow 1973, 77.). Taxonomic and Nomenclature Notes According to the List of Prokaryotic names with Standing in Nomenclature (LPSN), the taxonomic status of the genus Thermoflavimicrobium is: correct name (last update, February 2025) * . LPSN classification: Bacteria / Bacillati / Bacillota / Bacilli / Caryophanales / Thermoactinomycetaceae / Thermoflavimicrobium The genus Thermoflavimicrobium can also be recovered in the Genome Taxonomy Database (GTDB) as g__Thermoflavimicrobium (version v220) ** . GTDB classification: d__Bacteria / p__Bacillota / c__Bacilli / o__Thermoactinomycetales / f__Thermoactinomycetaceae / g__Thermoflavimicrobium * Meier‐Kolthoff et al. ( 2022 ). Nucleic Acids Res , 50 , D801 – D807 ; DOI: 10.1093/nar/gkab902 ** Parks et al. ( 2022 ). Nucleic Acids Res , 50 , D785 – D794 ; DOI: 10.1093/nar/gkab776
Nonnegative least-squares truncated singular value decomposition to particle size distribution inversion from dynamic light scattering data (2010)

The weak symmetry relationship between the relative error and solution norm holds in our developed nonnegative least-squares truncated singular value decomposition method. By using this relationship to specify the optimal regularization parameters, we applied the proposed algorithm to recover particle size distribution from dynamic light scattering (DLS) data. Simulated results and experimental validity demonstrate that the proposed method, which compliments the CONTIN algorithm, might serve as a powerful and simple approach to the inverse problem in DLS.
Mapping genomic hotspots of DNA damage by a single-strand-DNA-compatible and strand-specific ChIP-seq method (2012)

Spontaneous DNA damage may occur nonrandomly in the genome, especially when genome maintenance mechanisms are undermined. We developed single-strand DNA (ssDNA)-associated protein immunoprecipitation followed by sequencing (SPI-seq) to map genomic hotspots of DNA damage. We demonstrated this method with Rad52, a homologous recombination repair protein, which binds to ssDNA formed at DNA lesions. SPI-seq faithfully detected, in fission yeast, Rad52 enrichment at artificially induced double-strand breaks (DSBs) as well as endogenously programmed DSBs for mating-type switching. Applying Rad52 SPI-seq to fission yeast mutants defective in DNA helicase Pfh1 or histone H3K56 deacetylase Hst4, led to global views of DNA lesion hotspots emerging in these mutants. We also found serendipitously that histone dosage aberration can activate retrotransposon Tf2 and cause the accumulation of a Tf2 cDNA species bound by Rad52. SPI-seq should be widely applicable for mapping sites of DNA damage and uncovering the causes of genome instability.
Privacy-Preserving Machine Learning With Fully Homomorphic Encryption for Deep Neural Network (2022)

Fully homomorphic encryption (FHE) is a prospective tool for privacy-preserving machine learning (PPML). Several PPML models have been proposed based on various FHE schemes and approaches. Although FHE schemes are suitable as tools for implementing PPML models, previous PPML models based on FHE, such as CryptoNet, SEALion, and CryptoDL, are limited to simple and nonstandard types of machine learning models; they have not proven to be efficient and accurate with more practical and advanced datasets. Previous PPML schemes replaced non-arithmetic activation functions with simple arithmetic functions instead of adopting approximation methods and did not use bootstrapping, which enables continuous homomorphic evaluations. Thus, they could neither use standard activation functions nor employ large numbers of layers. In this work, we first implement the standard ResNet-20 model with the RNS-CKKS FHE with bootstrapping and verify the implemented model with the CIFAR-10 dataset and plaintext model parameters. Instead of replacing the non-arithmetic functions with simple arithmetic functions, we use state-of-the-art approximation methods to evaluate these non-arithmetic functions, such as ReLU and Softmax, with sufficient precision. Further, for the first time, we use the bootstrapping technique of the RNS-CKKS scheme in the proposed model, which enables us to evaluate an arbitrary deep learning model on encrypted data. We numerically verify that the proposed model with the CIFAR-10 dataset shows 98.43% identical results to the original ResNet-20 model with non-encrypted data. The classification accuracy of the proposed model is 92.43%±2.65%, which is quite close to that of the original ResNet-20 CNN model (91.89%). It takes approximately 3 h for inference on a dual Intel Xeon Platinum 8280 CPU (112 cores) with 172 GB of memory. We believe that this opens the possibility of applying FHE to an advanced deep PPML model.
SIR10US: A tightly coupled elliptic-curve cryptography co-processor for the OpenRISC (2014)

Today's embedded systems require resource-aware acceleration engines, which support advanced cryptographic algorithms such as elliptic-curve cryptography (ECC). The authors present an application-specific co-processor for digital signature verification according to the Elliptic Curve Digital Signature Algorithm (ECDSA) based on the NIST B-233 standard. A novel OpenRISC-ISA (instruction-set architecture) core featuring a high IPC rate and balanced pipeline stages has been developed to act as the main controlling unit of the accelerator. The redesigned OpenRISC core processes 67% more instructions per second than the reference architecture and ties with a micro-controllable ECC datapath through a highly optimized interface. An ECDSA signature is verified in 11 ms, which is equal to a speedup of 15× and 3.3× with respect to a portable C implementation on the OpenRISC and an assembler-optimized implementation on an ARM7, respectively. Moreover, thanks to a tightly coupled data memory, the proposed co-processor does not block the OpenRISC during its ECC-specific operations, thereby enabling it to also support concurrent execution of other workloads and/or software-based cryptographic extension functions.
Combining Aurophilic Interactions and Halogen Bonding To Control the Luminescence from Bimetallic Gold−Silver Clusters (2009)

The luminescence in a series of new bimetallic gold-silver vapochromic structures can be efficiently switched among different colors simply by exposure to solvent vapors. The emission color in these systems is controlled by both aurophilic interactions and halogen bonding, which affect the emission energy through different orbitals.
A numerical algorithm for the ITZ area fraction in concrete with elliptical aggregate particles (2008)

In view of the importance of the interfacial transition zone (ITZ) to the macro-properties of concrete, it is essential to determine the ITZ area fraction in concrete. Once the ITZ area fraction is known, the physico-mechanical properties of concrete can be predicted based on the three-phase composite model. The intention of the present paper is to develop a numerical algorithm for the ITZ area fraction in concrete with elliptical aggregate particles. By introducing a contact function for two ellipses, the elliptical aggregate particles with various sizes are distributed within a square element with periodic boundary conditions. The Monte Carlo method is then adopted to evaluate the ITZ area fraction. After verifying the developed numerical algorithm with the analytical solution for the ITZ area fraction in concrete with circular aggregate particles, the effects of key factors that affect the ITZ area fraction are examined in a quantitative manner. It is found in the paper that the ITZ area fraction increases with the increase of the ITZ thickness, but decreases with the increase of the maximum aggregate diameter and the ratio between the major and minor axes of elliptical aggregate particles. It is also found that the aggregate gradation has a significant influence on the ITZ area fraction. The paper concludes that the numerical algorithm presented in the paper can predict the ITZ area fraction with reasonable accuracy.
Liquid biopsies (2018)

Liquid biopsy is based on minimally invasive blood tests and has a high potential to significantly change the therapeutic strategy in cancer patients, providing an extremely powerful and reliable noninvasive clinical tool for the individual molecular profiling of patients in real time. Liquid biopsy approaches include the analysis of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating miRNAs, and tumor-derived extracellular vesicles (EVs) that are shed from primary tumors and their metastatic sites into peripheral blood. The major advantage of liquid biopsy analysis is that it is minimally invasive, and can be serially repeated, thus allowing extracting information from the tumor in real time. Moreover, the identification of predictive biomarkers in peripheral blood that can monitor response to therapy in real time holds a very strong potential for novel approaches in the therapeutic management of cancer patients. In this review, we summarize recent knowledge on CTCs and ctDNA and discuss future trends in the field.
A recursive extrapolation approach to intra prediction in video coding (2013)

A novel intra prediction scheme, based on recursive extrapolation filters, is introduced. Standard intra prediction largely consists of copying boundary pixels (or linear combinations thereof) along certain directions, which reflects an overly simplistic model for the underlying spatial correlations. As an alternative, we view the image signal as a 2-D non-separable Markov model, whose corresponding correlation model better captures the nuanced directionality effects within blocks. This viewpoint motivates the design of a set of prediction modes represented by three-tap extrapolation filters, which replace the standard “pixel-copying” prediction modes, and provide efficient prediction at modest complexity. The Markov property is exploited by recursive predictions from nearest neighbors without recourse to simplistic separability assumptions, and while effectively accounting for correlation decay with distance from available boundary pixels. Coefficients for the set of mode filters are first trained by an efficient “k-modes” iterative technique designed to monotonically decrease the mean squared prediction error, and are then adjusted to directly optimize the overall rate-distortion objective. This prediction scheme complements the hybrid (cosine and sine) transform coding approach developed by our group, to achieve consistent coding gains, as shown for standard and commercial intra coders such as H.264/AVC and VP8.
Oxidation of NO to NO2 on a Pt-MFI zeolite and subsequent reduction of NOx by C2H4 on an In-MFI zeolite: a novel de-NOx strategy in excess oxygen (1997)

Intermediate addition of reductant (C 2 H 4 ) into an NO+O 2 stream between an oxidation catalyst for NO to NO 2 (Pt-MFI) and a reduction catalyst for NO x to N 2 (In-MFI), a so-called IAR method, is shown to be very effective in selectively reducing NO to N 2 in the presence of excess oxygen.
Die pneumatische Dilatation zur Behandlung der Achalasie der Speiseröhre (1973)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Efficient speech enhancement by diffusive gain factors (DGF) (2001)

In this paper we propose a very simple but highly effective algorithm for single channel noise reduction of speech signals. One of the main objectives is to find a balanced tradeoff between noise reduction and speech distortion in the processed signal. This is accomplished by a system based on spectral minimum detection and diffusive gain factors. Our approach to speech enhancement is capable of distinguishing between speech and noise interference in the microphone signal, even when they are located in the same frequency band.
A fully compensated active pull-down ECL circuit with self-adjusting driving capability (1996)

A new active pull-down emitter-coupled logic (ECL) circuit having full compensation against fluctuations in supply voltage and temperature is proposed. This circuit needs no capacitors but a feed-back circuit to adjust its pull-down capability to its load capacitance. The speed performance is compared between the active pull-down ECL circuit and the conventional ECL circuit using 0.8 /spl mu/m SPICE parameters. The active pull-down ECL circuit is twice as fast as the conventional ECL circuit under the load capacitance of 0.8 pF with the same power dissipation. The relation between the power dissipation and the operating frequency is compared among the CMOS, the conventional ECL, and the active pull-down ECL circuits. The comparison adapts a new method in which the circuit parameters are optimized at each operating frequency. The SPICE simulation using this new method shows the conventional ECL circuit has a lower power dissipation than the CMOS circuit, even in the low operating frequency region of 100 MHz. The new active pull-down ECL circuit has the lowest power dissipation among the three circuits. The power dissipation of this circuit shows 47% lower than the CMOS circuit and 29% lower than the conventional ECL circuit at the operating frequency of 600 MHz and the load capacitance of 0.8 pF.
Prediction of metabolisable energy value of broiler diets and water excretion from dietary chemical analyses (2013)

Thirty various pelleted diets were given to broilers (8/diet) for in vivo measurements of dietary metabolisable energy (ME) value and digestibilities of proteins, lipids, starch and sugars from day 27 to day 31, with ad libitum feeding and total collection of excreta. Water excretion was also measured. Amino acid formulation of diets was done on the basis of ratios to crude proteins. Mean in vivo apparent ME values corrected to zero nitrogen retention (AMEn) were always lower than the AMEn values calculated for adult cockerels using predicting equations from literature based on the chemical analyses of diets. The difference between mean in vivo AMEn values and these calculated AMEn values increased linearly with increasing amount of wheat in diets (P = 0.0001). Mean digestibilities of proteins, lipids and starch were negatively related to wheat introduction (P = 0.0001). The correlations between mean in vivo AMEn values and diet analytical parameters were the highest with fibre-related parameters, such as water-insoluble cell-walls (WICW) (r = -0.91) or Real Applied Viscosity (RAV) (r = -0.77). Thirteen multiple regression equations relating mean in vivo AMEn values to dietary analytical data were calculated, with R² values ranging from 0.859 to 0.966 (P = 0.0001). The highest R² values were obtained when the RAV parameter was included in independent variables. The direct regression equations obtained with available components (proteins, lipids, starch, sucrose and oligosaccharides) and the indirect regression equations obtained with WICW and ash parameters showed similar R² values. Direct or indirect theoretical equations predicting AMEn values were established using the overall mean in vivo digestibility values. The principle of indirect equations was based on the assumption that WICW and ashes act as diluters. Addition of RAV or wheat content in variables improved the accuracy of theoretical equations. Efficiencies of theoretical equations for predicting AMEn values were almost the same as those of multiple regression equations. Water excretion was expressed either as the water content of excreta (EWC), the ratio of water excretion to feed intake (WIR) or the residual value from the regression equation relating water excretion to feed intake (RWE). The best regression predicting EWC was based on sucrose, fermentable sugars (lactose + oligosaccharides) and chloride variables, with positive coefficients. The best equations predicting WIR or RWE contained the sugar and chloride variables, with positive coefficients. Other variables appearing in these equations were AMEn or starch with negative coefficients, WICW, 'cell-wall-retained water', RAV or potassium with positive coefficients.
In defence of the nation‐state: securing the environment (1998)

The relationship between armed forces and the environment has been given greater attention in recent times. This paper seeks to develop a rationale for a positive relationship between the military and the environment. It seeks to make an holistic interpretation of military corporate goals such as ‘security’ of the nation and protecting the ‘people’ and national ‘interests’. In its examination of the environmental dimensions to these goals the paper highlights the understanding that the military's traditional contribution to society has been overly narrow, and that there is a pressing need to redefine the role of the military in the post cold war era. The paper will draw on Australian examples to illustrate its examination, and will conclude with an example of one way in which Australia's military can make a positive contribution to sustainable development. © 1998 John Wiley & Sons, Ltd and ERP Environment.
Handbook of Otoacoustic Emissions (1999)

Otoacoustic Emissions (OAE) Then and Now. Anatomy and Physiology. Spontaneous OAE (SOAE). Transient Evoked and Distortion Product OAE: Measurement an Analysis. Transient Evoked an Distortion Product OAE: Non-Pathologic Factors Influencing Measurement. Transient Evoked and Distortion Product OAE: Effect of Auditory Dysfunction. Clinical Applications of OAE in Children. Clinical Applications of OAE in Adults. Manufacturers Forum. Future Clinical Directions. References. Self-Test. Index.
Plan2Text: A framework for describing building floor plan images from first person perspective (2018)

We focus on synthesis of textual description from a given building floor plan image based on the first-person vision perspective. Tasks like symbol spotting, wall and decor segmentation, semantic and perceptual segmentation has been done in the past on floor plans. Here, for the first time, we propose an end-to-end framework for first person vision based textual description synthesis of building floor plans. We demonstrate (qualitative and quantitatively) that the proposed framework gives state of the art performance on challenging, real-world floor plan images. Potential application of this work could be understanding floor plans, stability analysis of buildings, and retrieval.