gebhart/patrepeval huggingface dataset:
Dengue seroprevalence: data from the clinical development of a tetravalent dengue vaccine in 14 countries (2005–2014) (2018)

Dengue seroprevalence data in the literature is limited and the available information is difficult to compare between studies because of the varying survey designs and methods used. We assessed dengue seropositivity across 14 countries using data from 15 trials conducted during the development of a tetravalent dengue vaccine between October 2005 and February 2014. Participants' dengue seropositivity (n=8592) was determined from baseline (before vaccination) serum samples at two centralized laboratories with the plaque reduction neutralization test (PRNT50). Seropositivity rates generally increased with age in endemic settings. Although seropositivity rates varied across geographical areas, between countries, and within countries by region, no major differences were observed for given age groups between the two endemic regions, Latin America and Asia-Pacific. Seropositivity rates were generally stable over time. The proportion of participants who had only experienced primary infection tended to be higher in younger children than adolescents/adults. These results will help inform and guide dengue control strategies in the participating countries.
Discharge physics and chemistry of a novel atmospheric pressure plasma source (1999)

Summary form only given, as follows. The atmospheric pressure plasma jet (APPJ) is a unique plasma source operating at atmospheric pressure. The APPJ operates with RF power and produces a stable non-thermal discharge in capacitively-coupled configuration. The discharge is spatially and temporally homogeneous and provides a unique gas phase chemistry that is well suited for various applications including etching, film deposition, surface treatment and decontamination of chemical and biological warfare (CBW) agents. A theoretical model shows electron densities of 0.2-2/spl times/10/sup 11/ cm/sup -3/ for a helium discharge at a power level of 3-30 W cm/sup -3/. The APPJ also produces a large flux, equivalent of up to 10000 monolayer s/sup -1/, of chemically-active, atomic and metastable molecular species which can impinge surfaces several cm downstream of the confined source. In addition, the efforts are in progress to measure the electron density using microwave diagnostics and to benchmark the gas phase chemical model by using LIF and titration.
Improved Color Coding For Scalable 3D Wavelet Video Compression (2015)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
An efficient hardware implementation of sequential stack decoding of binary block codes (2015)

This work proposes an efficient hardware Implementation of sequential stack decoding of binary block codes. The decoder can be applied for soft input decoding for generalized concatenated (GC) codes. The GC codes are constructed from inner nested binary Bose-Chaudhuri-Hocquenghem (BCH) codes and outer Reed-Solomon (RS) codes. In order to enable soft input decoding for the inner BCH block codes, a sequential stack decoding algorithm is used.
Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response (2013)

Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These materials provide robust mechanical strength and are quickly incorporated into host tissue; factors that contribute to reduced hernia recurrence rates. However, such mesh devices cause a foreign body response with the associated complications of fibrosis and patient discomfort. In contrast, surgical mesh devices composed of naturally occurring extracellular matrix (ECM) are associated with constructive tissue remodeling, but lack the mechanical strength of synthetic materials. A method for applying a porcine dermal ECM hydrogel coating to a polypropylene mesh is described herein with the associated effects upon the host tissue response and biaxial mechanical behavior. Uncoated and ECM coated heavy-weight BARD™ Mesh were compared to the light-weight ULTRAPRO™ and BARD™ Soft Mesh devices in a rat partial thickness abdominal defect overlay model. The ECM coated mesh attenuated the pro-inflammatory response compared to all other devices, with a reduced cell accumulation and fewer foreign body giant cells. The ECM coating degraded by 35 days, and was replaced with loose connective tissue compared to the dense collagenous tissue associated with the uncoated polypropylene mesh device. Biaxial mechanical characterization showed that all of the mesh devices were of similar isotropic stiffness. Upon explanation, the light-weight mesh devices were more compliant than the coated or uncoated heavy-weight devices. This study shows that an ECM coating alters the default host response to a polypropylene mesh, but not the mechanical properties in an acute in vivo abdominal repair model.
Peak-seeking control using gradient and Hessian estimates (2010)

A peak-seeking control method is presented which utilizes a linear time-varying Kalman filter. Performance function coordinate and magnitude measurements are used by the Kalman filter to estimate the gradient and Hessian of the performance function. The gradient and Hessian are used to command the system toward a local extremum. The method is naturally applied to multiple-input multiple-output systems. Applications of this technique to a single-input single-output example and a two-input one-output example are presented.
Filter Architecture Operating Beyond the Q Limit and With Real-Time Bandwidth Tunability (2021)

Novel radio paradigms such as software-defined radios and 5G pose stringent challenges for RF filter designers, as compact footprint, narrow-band operation, and real-time reconfigurability are required simultaneously. To address some of these challenges, we introduce a novel filter architecture based on spatio-temporal commutation of identical resonators that surpasses the limits dictated by resonator quality factor in narrow-band applications. This novel topology achieves outstanding real-time bandwidth control by tuning the commutation strategy. With a working point significantly different than conventional N-path networks, modulation frequencies which are a small fraction of the filter center frequency are demonstrated, relaxing electronics requirements. A compact PCB demonstration of such a filter operating at 100MHz is designed and measured, validating the simulated performance, with an insertion loss of 3dB and fractional bandwidths ranging from 50% to 100%, switching between four identical LC tanks.
Inhibition of Influenza A Virus Replication by Resveratrol (2005)

We have previously shown that the life cycles of several viruses are influenced by host-cell redox states. Reports of the antioxidant activities of the plant polyphenol resveratrol (RV) prompted us to investigate its effects on influenza virus replication in vitro and in vivo. We found that RV strongly inhibited the replication of influenza virus in MDCK cells but that this activity was not directly related to glutathione-mediated antioxidant activity. Rather, it involved the blockade of the nuclear-cytoplasmic translocation of viral ribonucleoproteins and reduced expression of late viral proteins seemingly related to the inhibition of protein kinase C activity and its dependent pathways. RV also significantly improved survival and decreased pulmonary viral titers in influenza virus-infected mice. No toxic effects were observed in vitro or in vivo. That RV acts by inhibiting a cellular, rather than a viral, function suggests that it could be a particularly valuable anti-influenza drug.
Least Squares Superposition Codes of Moderate Dictionary Size, Reliable\n at Rates up to Capacity (2010)

For the additive white Gaussian noise channel with average codeword power\nconstraint, new coding methods are devised in which the codewords are sparse\nsuperpositions, that is, linear combinations of subsets of vectors from a given\ndesign, with the possible messages indexed by the choice of subset. Decoding is\nby least squares, tailored to the assumed form of linear combination.\nCommunication is shown to be reliable with error probability exponentially\nsmall for all rates up to the Shannon capacity.\n
Three‐dimensional magnetic resonance myocardial motion tracking from a single image plane (2007)

Three-dimensional imaging for the quantification of myocardial motion is a key step in the evaluation of cardiac disease. A tagged magnetic resonance imaging method that automatically tracks myocardial displacement in three dimensions is presented. Unlike other techniques, this method tracks both in-plane and through-plane motion from a single image plane without affecting the duration of image acquisition. A small z-encoding gradient is subsequently added to the refocusing lobe of the slice-selection gradient pulse in a slice following CSPAMM acquisition. An opposite polarity z-encoding gradient is added to the orthogonal tag direction. The additional z-gradients encode the instantaneous through plane position of the slice. The vertical and horizontal tags are used to resolve in-plane motion, while the added z-gradients is used to resolve through-plane motion. Postprocessing automatically decodes the acquired data and tracks the three-dimensional displacement of every material point within the image plane for each cine frame. Experiments include both a phantom and in vivo human validation. These studies demonstrate that the simultaneous extraction of both in-plane and through-plane displacements and pathlines from tagged images is achievable. This capability should open up new avenues for the automatic quantification of cardiac motion and strain for scientific and clinical purposes.
Conjugates of Catecholamines. 6. Synthesis and β-Adrenergic Activity of N - (Hydroxyalkyl)catecholamine Derivatives (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConjugates of Catecholamines. 6. Synthesis and β-Adrenergic Activity of N - (Hydroxyalkyl)catecholamine DerivativesAllen B. Reitz, Mitchell A. Avery, Roberto P. Rosenkranz, Michael S. Verlander, Kenneth L. Melmon, Brian B. Hoffman, Yasio Akita, Neal Castagnoli, and Murry GoodmanCite this: J. Med. Chem. 1985, 28, 5, 642–647Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/jm50001a018https://doi.org/10.1021/jm50001a018research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Virtual machines (2009)

This article addresses a problem of performance monitoring inside virtual machines (VMs). It advocates focused monitoring of particular virtualized programs, explains the need for and the importance of such an approach to performance monitoring in virtualized execution environments, and emphasizes its benefits for virtual machine manufacturers, virtual machine users (mostly, software developers) and hardware (processor) manufacturers. The article defines the problem of in-VM performance monitoring as the ability to employ modern methods and hardware performance monitoring capabilities inside virtual machines to an extent comparable with what is being done in real environments. Unfortunately, there are numerous reasons preventing us from achieving such an ambitious goal, one of those reasons being the lack of support from virtualization engines; that is why a novel method of 'cooperative' performance data collection is disclosed. The method implies collection of performance data at physical hardware and simultaneous tracking of software states inside a virtual machine. Each statistically visible execution point of the virtualized software may then be associated with information on real hardware events. The method effectively enables time-based sampling of virtualized workloads combined with hardware event counting, is applicable to unmodified, commercially available virtual machines, and has competitive precision and overhead. The practical significance and value of the method are further illustrated by studying a parallel workload and uncovering virtualization-specific performance issues of multithreaded programs.
Polarization independent isolator using spatial walkoff polarizers (1989)

A novel type of polarization-independent optical isolator is described which utilizes the polarization walkoff provided by birefringent crystals. Isolation of 44 dB is measured at a wavelength of 1.3 mu m with single-mode fiber insertion loss of 1.5 dB. A temperature-independent scheme is also described that provides at least 39 dB of isolation over the temperature range of 25-75 degrees C.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reduction of field of view in MRI using a surface‐spoiling local gradient insert (1998)

Herein is presented a method for suppressing the magnetic resonance signal to a controlled depth by applying a spatially heterogeneous spoiler field between the slice-select and readout pulses. Eliminating the signal from near-surface regions allows one to shrink the field of view without introducing aliasing artifacts, thereby decreasing imaging time over a smaller defined volume. A unique planar magnetic gradient coil was constructed to generate the spoiler field. Phantom and human subject studies showed that the signal can be suppressed to controlled distances of up to 90 mm from the coil, with modest requirements on power supplies, pulse sequences, and materials, and with no increase in imaging time.
Statistical Timing Analysis considering Multiple-Input Switching (2020)

Traditional statistical static timing analysis (SSTA) using available single-input switching (SIS) based gate delay libraries either ignore timing impact from multiple-input switching (MIS) or use single-corner (deterministic) models for MIS consideration. This paper presents a method for modeling the impact of MIS on statistical timing accurately using concepts of convolution and chain ruling. Experimental results in a commercial SSTA framework demonstrate negligible run-time overheads of modeling MIS while accurately exposing timing slack optimism in an SIS based flow of up to 17 pico-seconds on designs mapped to a 14 nanometer technology library. Prediction of timing critical paths due to MIS show excellent correlation to silicon hardware. Comparisons with prior work illustrate the accuracy improvements of the presented work.
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency (2015)

Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine. Clinical features of arginase deficiency include elevated plasma arginine levels, spastic diplegia, intellectual disability, seizures and growth deficiency. Unlike other urea cycle disorders, recurrent hyperammonemia is typically less severe in this disorder. Normalization of plasma arginine levels is the consensus treatment goal, because elevations of arginine and its metabolites are suspected to contribute to the neurologic features. Using data from patients enrolled in a natural history study conducted by the Urea Cycle Disorders Consortium, we found that 97% of plasma arginine levels in subjects with arginase deficiency were above the normal range despite conventional treatment. Recently, arginine-degrading enzymes have been used to deplete arginine as a therapeutic strategy in cancer. We tested whether one of these enzymes, a pegylated human recombinant arginase 1 (AEB1102), reduces plasma arginine in murine models of arginase deficiency. In neonatal and adult mice with arginase deficiency, AEB1102 reduced the plasma arginine after single and repeated doses. However, survival did not improve likely, because this pegylated enzyme does not enter hepatocytes and does not improve hyperammonemia that accounts for lethality. Although murine models required dosing every 48 h, studies in cynomolgus monkeys indicate that less frequent dosing may be possible in patients. Given that elevated plasma arginine rather than hyperammonemia is the major treatment challenge, we propose that AEB1102 may have therapeutic potential as an arginine-reducing agent in patients with arginase deficiency.
New device for percutaneous fragmentation of pulmonary emboli. (1991)

A new catheter system was designed for percutaneous fragmentation of large pulmonary emboli. The device consists of an impeller rotating at high speed at the center of a self-expandable basket at the tip of a 7-F catheter. The highly flexible catheter was able to reach all tested embolus sites in a glass model of the pulmonary arterial tree. Embolus fragmentation was quick and thorough. Particles in the effluent larger than 10 microns accounted for only about 9% of the treated embolus weight. Wall contact with the rotating impeller was not observed. The impeller-basket catheter promises to be a useful tool for percutaneous treatment of acute pulmonary embolism.
<title>Space processing of biopolymer/metal composites for NLO applications</title> (1996)

Crystals grown in space have been shown to be of higher quality than 'earth-grown' crystals because defect-free specimens are obtained in the absence of gravity-fueled convection. Defect-free organic crystals are of particular interest because they can exhibit high optical nonlinearities. However, as these are molecular crystals, they tend to be brittle and cannot be easily fabricated into thin films or fibers as can polymer analogs. Polymers having a controlled supramolecular structure and morphology are even more promising candidates as nonlinear optical materials (NLOM). We have previously demonstrated the rationale for orienting biopolymers, materials with known supramolecular structure, in an electric field under microgravity conditions in order to optimize the nonlinearity of the biopolymer. Now focusing on the feasibility of improving upon the NLO activity of the biopolymer system by using a metal dopant, we report on the morphological characterization of electric field aligned polymer/silver colloid composites. By analogy to the microgravity processing of metal/ceramic alloys (known as 'cermets'), the resulting 'polymet' should benefit from homogeneous orientation of the minor metal phase within the polymer phase and further contribute to the potential of polymeric NLOM.
Multiple description trellis-coded quantization (1999)

We present a construction of multiple description trellis-coded quantizers. We use the tensor product of trellises to build a trellis which is applicable to multiple description coding. The problems of index assignment and set partitioning for the resulting trellis are considered. The Viterbi algorithm provides the best path for encoding and the design procedure utilizes a generalized Lloyd algorithm. The encoding process simultaneously generates all the transmitted sequences. Furthermore, the complexity of the scheme is almost independent of the rate. The quantizer provides remarkable performance with little encoding complexity.
DEVELOPMENT OF CONTINUOUS SOLVENT EXTRACTION PROCESSES FOR COAL DERIVED CARBON PRODUCTS (2005)

The purpose of this DOE-funded effort is to develop continuous processes for solvent extraction of coal for the production of carbon products. These carbon products include materials used in metals smelting, especially in the aluminum and steel industries, as well as porous carbon structural material referred to as ''carbon foam'' and carbon fibers. The Hydrotreatment Facility is being prepared for trials with coal liquids. Raw coal tar distillate trials have been carried out by heating coal tar in the holding tank in the Hydrotreatment Facility. The liquids are centrifuged to warm the system up in preparation for the coal liquids. The coal tar distillate is then recycled to keep the centrifuge hot. In this way, the product has been distilled such that a softening point of approximately 110 C is reached. Then an ash test is conducted.
Convolutional neural networks automate detection for tracking of submicron-scale particles in 2D and 3D (2018)

Particle tracking is a powerful biophysical tool that requires conversion of large video files into position time series, i.e., traces of the species of interest for data analysis. Current tracking methods, based on a limited set of input parameters to identify bright objects, are ill-equipped to handle the spectrum of spatiotemporal heterogeneity and poor signal-to-noise ratios typically presented by submicron species in complex biological environments. Extensive user involvement is frequently necessary to optimize and execute tracking methods, which is not only inefficient but introduces user bias. To develop a fully automated tracking method, we developed a convolutional neural network for particle localization from image data, comprising over 6,000 parameters, and used machine learning techniques to train the network on a diverse portfolio of video conditions. The neural network tracker provides unprecedented automation and accuracy, with exceptionally low false positive and false negative rates on both 2D and 3D simulated videos and 2D experimental videos of difficult-to-track species.
The role of compressional pressure in the formation of dense bubble clouds in histotripsy (2009)

Histotripsy is a non-invasive ultrasound therapy which utilizes cavitation clouds to mechanically fractionate tissue. The mechanism by which bubble clouds form is important to understand the histotripsy process. We used high speed imaging with frame rates between 0.1 – 10 million fps to observe the progression of cloud formation. A 1 MHz spherically-focused transducer was used to apply single histotripsy pulses to optically-transparent gelatin tissue phantoms, with peak negative pressure of 19 MPa and 5–50 cycles. Dense bubble clouds were observed to first form at a distal position within the focus, and grow proximally towards the transducer, opposite the ultrasound propagation direction. Growth began from the site of single cavitation bubbles. Based on these observations, it was hypothesized that the shocked waveforms from histotripsy pulses scatter from single bubbles, which invert the shock and induce a large negative pressure in its vicinity. To test this hypothesis, the positive incident shock pressure was reduced without significantly affecting the negative pressure. When the peak positive pressure was lowered, the likelihood and size of bubble clouds initiating at the focus was greatly reduced. These results suggest that the positive pressure of the incident waveform is important for generating bubble clouds in histotripsy.