gebhart/patrepeval huggingface dataset:
Load/unload investigations on a rotary actuator disk drive (1992)

Head-disk contacts in a disk file with a rotary actuator are examined during load/unload using laser Doppler vibrometry and acoustic emission techniques. A novel scheme that allows tracking of the slider with the laser beam of a laser Doppler vibrometer during load/unload is implemented. Head-disk contacts are found to occur as a function of the velocity of the slider along the inclined ramp prior to loading, and it is shown that a low vertical loading velocity is less likely to introduce head-disk contacts than a high loading velocity. For the swing-arm actuated drive investigated, head-disk contacts start to appear at loading velocities as low as 25 mm/s. A careful design of the tip of the ramp is of utmost importance in ramp loading mechanisms to reduce the effective vertical component of the slider as it comes off the tip of the ramp during loading.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Preparation and characterization of polymeric solid electrolytes from poly(alkylene sulfides) and silver salts (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and characterization of polymeric solid electrolytes from poly(alkylene sulfides) and silver saltsS. Clancy, D. F. Shriver, and L. A. OchrymowyczCite this: Macromolecules 1986, 19, 3, 606–611Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/ma00157a020https://doi.org/10.1021/ma00157a020research-articleACS PublicationsRequest reuse permissionsArticle Views349Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Distribution System State Estimation Using an Artificial Neural Network Approach for Pseudo Measurement Modeling (2012)

This paper presents an alternative approach to pseudo measurement modeling in the context of distribution system state estimation (DSSE). In the proposed approach, pseudo measurements are generated from a few real measurements using artificial neural networks (ANNs) in conjunction with typical load profiles. The error associated with the generated pseudo measurements is made suitable for use in the weighted least squares (WLS) state estimation by decomposition into several components through the Gaussian mixture model (GMM). The effect of ANN-based pseudo measurement modeling on the quality of state estimation is demonstrated on a 95-bus section of the U.K. generic distribution system (UKGDS) model.
[Parallel analysis of c-Fos protein and interleukin-2 expression in hypothalamic cells under different influence]. (2007)

The objective of this work was to perform a parallel analysis of activation of the rat anterior hypothalamus cells as judged by c-Fos protein expression, and of the expression of interleukin-2 (IL-2) under different influences, i. e., mild stress (handling) and adaptation to it, and intranasal administration of saline and the peptides Vilon (Lys-Glu) and Epithalon (Ala-Glu-Asp-Gly). Changes in the counts of cells positive for c-Fos- and IL-2 proteins were studied in structures of the lateral (LHA) area, anterior (AHN), supraoptic (SO) and paraventricular (PVH) nuclei of Wistar rat hypothalamus. Quantity of the interleukin-2-positive and c-Fos-positive cells was calculated. The findings were: a negative correlation between the activation of cells and the amount of IL-2 in the cells in the hypothalamic structures under study, and the specific patterns of changes in the counts of cells positive for c-Fos and IL-2 under stress and adaptation to stress.
<title>Comparisons of deformable-mirror models and influence functions</title> (1991)

Modeling of deformable mirror (DM) surfaces is reviewed and two different types of DM models are compared. The first model creates the DM surface through the superposition of an influence function over the extended actuators. The second model uses a two-dimensional cubic spline fit over the extended actuators to create the DM surface. The ability of the predicted DM surface to correct for different spatial frequencies was investigated. It is shown that correctability may vary in both magnitude and shape over the applicable range of frequencies. Results indicate that the bi-cubic spline model is the easiest and fastest to use and it may be extended to incorporate more advanced features.
Design and characterization of evanescently-coupled photodiodes for 1.3 &#x03BC;m wavelength (2014)

The evanescently coupled waveguide photodiode (ECPD) has been fabricated and used for the generation of continuous-wave (CW) terahertz (THz) field at a 1.3 μm wavelength. We designed a matching layer to evanescently couple the optical beam from the base waveguide to the active region so as to get a high responsivity, 0.36 A/W. We also measured CW THz photocurrent at 350 GHz using log-periodic antenna-integrated ECPD as emitting photomixer. We get the signal-to-noise ratio of about 60dB.
Testing and Monitoring Model-based Generated Program (2003)

We propose an integrated framework to test and monitor code generated from hybrid models for embedded systems. The framework consists of the following elements: First, we create a testing automaton as a controlled environment to produce test traces achieving the desired testing criteria; Second, we synthesize a monitoring automaton from the behavior specification to check the run-time behavior of the tested system in response to the test traces; Finally, since both automata are encoded in the same language as the system model, the same code generator may be used to generate a tester and a monitor from the testing automaton and the monitoring automaton. The tester and the monitor may be linked as needed with the code generated from the system model. Our approach yields self-testing and self-monitoring code which may be run both on the simulation level and on the code level. We discuss our approach in its full details through an example on a SONY AIBO robotic dog.
A single-molecule assessment of the protective effect of DMSO against DNA double-strand breaks induced by photo-and γ-ray-irradiation, and freezing (2017)

Dimethyl sulfoxide (DMSO) is widely used as a cryoprotectant for organs, tissues, and cell suspension in storage. In addition, DMSO is known to be a useful free radical scavenger and a radio-protectant. To date, many in vitro assays using cultured cells have been performed for analysing the protective effect of DMSO against genomic DNA damage; however, currently it has been rather difficult to detect DNA double strand breaks (DSBs) in a quantitative manner. In the present study, we aimed to observe the extent of DNA damage by use of single molecular observation with a fluorescence microscope to evaluate DSBs induced by photo- and γ-ray-irradiation, or freeze/thawing in variable concentrations of DMSO. As a result, we found that 2% DMSO conferred the maximum protective effect against all of the injury sources tested, and these effects were maintained at higher concentrations. Further, DMSO showed a significantly higher protective effect against freezing-induced damage than against photo- and γ-ray-irradiation-induced damage. Our study provides significant data for the optimization of DNA cryopreservation with DMSO, as well as for the usage of DNA as the protective agent against the injuries caused by active oxygen and radiations.
Comparative genomic analysis of prion genes (2007)

It is likely that the conserved genomic elements identified in this analysis represent bona fide cis-elements. However, this idea needs to be confirmed by functional assays in transgenic systems.
The Use of Technetium-99m Radiolabeled Human Antimicrobial Peptides for Infection Specific Imaging (2008)

Bacterial resistance to conventional antibiotics poses a challenge medicine to search for alternatives. Cationic antimicrobial peptides (AMPs) are promising for the development of a new class of antibiotics. This review focuses on the use of technetium-99m labeled synthetic AMPs, derived from human natural cationic AMPs, for target-delivery to and in vivo detection of infection sites caused by (drug-resistant) micro-organisms. The scintigraphic approach has proven to be a reliable method for evaluating AMPs in pharmacological studies and for optimizing target-delivery of radiolabeled AMPs to pathological sites in animals and humans. In addition, the effect of alterations in amphipathicity, amino acid substitution, and dimerization on the biological performance of AMPs is reported. Radiolabeled AMPs offer good perspectives for diagnosis of infections, for monitoring therapy, and, most importantly, for the ability to discriminate between infections and sterile inflammatory processes.
X‐ray diffraction analysis of myelin lipid/proteolipid protein multilayers (1989)

To examine the proposal that myelin proteolipid protein underlies the adhesion of neighboring membranes in central nervous system (CNS) myelin, we carried out X-ray diffraction studies on the structure and interactions of model bilayers composed of total myelin lipids plus proteolipid apoprotein (PLP). Total myelin lipids were used because their heterogeneity was expected to provide an appropriate environment for the integral membrane protein to achieve its native conformation and establish appropriate contacts with the apposed bilayer. We found that incorporation of PLP into myelin lipid bilayers, whether organized into multilamellar vesicles or oriented multilayers, did not appreciably affect the lamellar period, which ranged from 65-71 A. In oriented multilayers, the wide-angle spacing at approximately 4.8 A, which arises from the lateral packing of lipid chains and is perpendicular to the lamellar diffraction, was less oriented and weaker in bilayers containing the protein. These results indicate that PLP was incorporated into the bilayers and had a disordering effect on the hydrocarbon chains but did not extend into the spaces between bilayers. Bilayer profiles calculated from the lamellar diffraction to about 15 A spacing did not show any major changes in the distribution of electron density, suggesting that to moderate resolution, the protein was distributed uniformly across the width of the lipid bilayer. Periodicities measured from osmotically stressed multilamellar vesicles did not depend on the presence of PLP, indicating that the protein did not form stabilizing contacts between bilayers.(ABSTRACT TRUNCATED AT 250 WORDS)
Does Hydrophilic Polydopamine Coating Enhance Membrane Rejection of Hydrophobic Endocrine-Disrupting Compounds? (2016)

Endocrine-disrupting compounds (EDCs), an important class of micropollutants with potent adverse health effects, are generally poorly rejected by traditional thin film composite polyamide membranes and thus pose significant risks in membrane-based water reclamation. We hypothesize that membrane rejection of hydrophobic EDCs can be enhanced by a hydrophilic surface coating. Using polydoamine (PDA) as a model hydrophilic coating layer, the PDA-coated NF90 membrane experienced an up to 75% reduction in the passage of bisphenol A compared to the control (NF90 without coating). Meanwhile, we also observed a systematic increase in the level of rejection of three hydrophobic parabens with an increase in PDA coating time. In contrast, there were no systematic changes in the rejection of neutral hydrophilic polyethylene glycol, which suggests that the enhanced rejection of EDCs was due to weakened EDC–membrane hydrophobic interaction. Further sorption tests revealed that the hydrophilic PDA coating could effectively decrease the rate of sorption of EDCs by the membrane, which is responsible for the improved rejection as predicted by the solution–diffusion theory. This study reveals an exciting opportunity for engineering membrane surface properties to enhance the rejection of targeted micropollutants, which has important implications in membrane-based water reclamation.
Tumor necrosis factor-<i>alpha</i> production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 <i>beta</i>. (1990)

Astrocytes have the capacity to secrete or respond to a variety of cytokines including IL-1, IL-6, IL-3, and TNF-alpha. In this study, we have examined the capacity of astrocytes to secrete TNF-alpha in response to a variety of biologic stimuli, particularly cytokines such as IL-1 and IFN-gamma, which are known to be present in the central nervous system during neurologic diseases associated with inflammation. Rat astrocytes do not constitutively produce TNF-alpha, but have the ability to secrete TNF-alpha in response to LPS, and can be primed by IFN-gamma to respond to a suboptimal dose of LPS. IFN-gamma and IL-1 beta alone do not induce TNF-alpha production, however, the combined treatment of IFN-gamma and IL-1 beta results in a striking synergistic effect on astrocyte TNF-alpha production. Astrocyte TNF-alpha protein production induced by a combined treatment of either IFN-gamma/LPS or IFN-gamma/IL-1 beta occurs in a dose- and time-dependent manner, and appears to require a "priming signal" initiated by IFN-gamma, which then renders the astrocyte responsive to either a suboptimal dose of LPS or IL-1 beta. Astrocyte TNF-alpha production by IFN-gamma/LPS stimulation can be inhibited by the addition of anti-rat IFN-gamma antibody, whereas IFN-gamma/IL-1-induced TNF-alpha production is inhibited by antibody to either IFN-gamma or IL-1 beta. Polyclonal antisera reactive with mouse macrophage-derived TNF-alpha neutralized the cytotoxicity of IFN-gamma/LPS and IFN-gamma/IL-1 beta-induced astrocyte TNF-alpha, demonstrating similarities between these two sources of TNF-alpha. We propose that astrocyte-produced TNF-alpha may have a pivotal role in augmenting intracerebral immune responses and inflammatory demyelination due to its diverse functional effects on glial cells such as oligodendrocytes and astrocytes themselves.
Drilling a Better Pair: New Technologies in SAGD Directional Drilling (2010)

Abstract The precise placement of well pairs is one of the most crucial factors in the successful execution of a steam assisted gravity drainage (SAGD) drilling program. A SAGD drilling program includes placing the producer well relative to the reservoir boundaries, as well as accurately twinning the producer with the injector well. Delivering on these high expectations in unconsolidated formations, such as the McMurray oil sands, requires a strong focus on technological innovation. A common practice in drilling SAGD wells in northeast Alberta is to drill lateral SAGD pairs with conventional steerable mud motors and logging-while-drilling (LWD) resistivity measurements. Although this combination has delivered success, certain limitations exist in terms of wellbore quality and placement. At the Statoil Leismer Demonstration Project, several industry firsts were successfully implemented, including a combination of the newest and most cutting-edge directional, measurement, and LWD technology. The keystone of these industry firsts was the application of a soft formation modified, point-the-bit rotary steerable system (RSS), used on 20 horizontal wells. Combined with an ultra deep azimuthal resistivity sensor, the RSS provided precise geosteering along the bottom bed boundary in the producer wells, resulting in improved reservoir capture and reservoir characterization. More on-bottom time enabled more efficient drilling and significantly reduced well costs. Smooth, almost effortless liner runs reflected the lack of tortuosity in the wellbore, made possible by the rotary bottom hole assembly (BHA). Improved directional control made uniform well separation possible between lateral pairs, thereby reducing the risk of hot spots and short-circuiting during SAGD operations. The use of an even-walled power section above the RSS increased the bit RPM for improved BHA responsiveness while minimizing casing and pipe wear. Overall, the results and lessons learned from the demonstration of these new techniques provide a clear indication of the progressive future of directional drilling in SAGD.
Schizophrenia – a Brain Disease? a Critical Review of Structural and Functional Cerebral Abnormality in the Disorder (1995)

Schizophrenia is characterised by minor structural abnormality which, in the case of lateral ventricular enlargement, may be better understood as a risk factor than a causative lesion. The functional imaging findings are not transparent but suggest that, as a disorder, schizophrenia shows complex alterations in regional patterns of activity rather than any simple deficit in prefrontal function.
Evaluation of local features for person re-identification in image sequences (2011)

In this paper we present a comparative study of local features for the task of person (re) identification. A combination of state of the art interest point detectors and descriptors is evaluated. The experiments are performed on a novel dataset which we make publicly available for future research in this area. The results indicate that there are significant differences between the evaluated descriptors, with GLOH and SIFT outperforming both Shape Context and SURF descriptors. The evaluated interest point descriptors perform equally well, with a slight advantage for the Hessian-Laplace detector. The Harris-Affine and Hessian-Affine affine invariant region detectors do not provide any performance advantage and therefore do not justify their additional computational expense.
Full Spectrum Millimeter-Wave Modulation in Thin-Film LiNbO<inf>3</inf> (2018)

We present a crystal ion sliced (CIS) LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> phase modulator that demonstrates functionality across the entire millimeter wave spectrum. A shallow rib waveguide supports a single transverse electric (TE) optical mode, and a Au coplanar waveguide (CPW) supports the modulating radio frequency (RF) mode.
Specific allergen immunotherapy: effect on immunologic markers and clinical parameters in asthmatic children. (2007)

SIT with D pteronyssinus improves immunological and clinical parameters in mite-allergic asthmatic children after 1 year of treatment. The skin prick test may be used as a marker of efficacy of therapy.
Immunostimulatory properties of phosphorothioate CpG DNA containing both 3'-5'- and 2'-5'-internucleotide linkages (2002)

Synthetic oligodeoxyribonucleotides containing CpG-dinucleotides (CpG DNA) in specific sequence contexts activate the vertebrate immune system. We have examined the effect of 3'-deoxy-2'-5'-ribonucleoside (3'-deoxynucleoside) incorporation into CpG DNA on the immunostimulatory activity. Incorporation of 3'-deoxynucleosides results in the formation of 2'-5'-internucleotide linkages in an otherwise 3'-5'-linked CpG DNA. In studies, both in vitro and in vivo, CpG DNA containing unnatural 3'-deoxynucleoside either within the CpG-dinucleotide or adjacent to the CpG-dinucleotide failed to induce immunostimulatory activity, suggesting that the modification was not recognized by the receptors. Incorporation of the same modification distal to the CpG-dinucleotide in the 5'-flanking sequence potentiated the immunostimulatory activity of the CpG DNA. The same modification when incorporated in the 3'-flanking sequence had an insignificant effect on immunostimulatory activity of CpG DNA. Interestingly, substitution of a 3'-deoxynucleoside in the 5'-flanking sequence distal to the CpG-dinucleotide resulted in increased IL-6 and IL-10 secretion with similar levels of IL-12 compared with parent CpG DNA. The incorporation of the same modification in the 3'-flanking sequence resulted in lower IL-6 and IL-10 secretion with similar levels of IL-12 compared with parent CpG DNA. These results suggest that site-specific incorporation of 3'-deoxynucleotides in CpG DNA modulates immunostimulatory properties.
Characterization of EvgAS-YdeO-GadE Branched Regulatory Circuit Governing Glutamate-Dependent Acid Resistance in<i>Escherichia coli</i> (2004)

Escherichia coli prefers growth in neutral pH environments but can withstand extremely acidic conditions (pH 2) for long periods. Of the four E. coli systems that contribute to acid resistance, one, the glutamate-dependent system, is remarkable in its efficacy and regulatory complexity. The resistance mechanism involves the intracellular consumption of protons by the glutamate decarboxylase isozymes GadA and GadB. The antiporter GadC then exports the product, gamma-aminobutyric acid, in exchange for fresh glutamate. A microarray study using overexpressed regulators uncovered evgAS and ydeO as potential regulators of gadE, now known to encode the essential activator of the gadA and gadBC genes. Examination of evgA and ydeO under normal expression conditions revealed that their products do activate gadE expression but only under specific conditions. They were important during exponential growth in acidified minimal medium containing glucose but were unnecessary for gadE expression in stationary-phase cells grown in complex medium. The response regulator EvgA activates gadE directly and indirectly via induction of the AraC-like regulator ydeO. Evidence obtained using gadE-lacZ operon fusions also revealed that GadE was autoinduced. Electrophoretic mobility shift assays indicated that EvgA, YdeO, and GadE bind to different regions upstream of gadE, indicating they all act directly at the gadE promoter. Since GadE controls the expression of numerous genes besides gadA and gadBC, the relevance of these regulatory circuits extends beyond acid resistance.