gebhart/patrepeval huggingface dataset:
<i>PIM1</i> gene cooperates with human <i>BCL6</i> gene to promote the development of lymphomas (2012)

Diffuse large B-cell lymphomas in humans are associated with chromosomal rearrangements (∼40%) and/or mutations disrupting autoregulation (∼16%) involving the BCL6 gene. Studies of lymphoma development in humans and mouse models have indicated that lymphomagenesis evolves through the accumulation of multiple genetic alterations. Based on our prior studies, which indicated that carcinogen-induced DNA mutations enhance the incidence of lymphomas in our mouse model expressing a human BCL6 transgene, we hypothesized that mutated genes are likely to play an important cooperative role in BCL6-associated lymphoma development. We used retroviral insertional mutagenesis in an effort to identify which genes cooperate with BCL6 in lymphomagenesis in our BCL6 transgenic mice. We identified PIM1 as the most frequently recurring cooperating gene in our murine BCL6-associated lymphomas (T- and B-cell types), and we observed elevated levels of PIM1 mRNA and protein expression in these neoplasms. Further, immunohistochemical staining, which was performed in 20 randomly selected BCL6-positive human B- and T-cell lymphomas, revealed concurrent expression of BCL6 and PIM1 in these neoplasms. As PIM1 encodes a serine/threonine kinase, PIM1 kinase inhibition may be a promising therapy for BCL6/PIM1-positive human lymphomas.
Modeling and characterization of the CEJ for optimization of esthetic implant design. (2004)

This study evaluated the dimensions and characteristics of the cementoenamel junction (CEJ) of maxillary anterior teeth; the natural CEJ was compared to current implant design and used for design optimization. Standardized digital images of 137 extracted human teeth (45 central incisors, 46 lateral incisors, and 46 canines) were used to measure cervical dimensions, CEJ curvature, and distance from zenith of CEJ to interdental contact on proximal views. The x- and y-coordinates of the CEJ contour were digitized before mathematic processing to allow the representation of a single average curve for buccal, palatal, mesial, and distal surfaces for each tooth type. These measurements were combined to existing data related to dentogingival and "implantomucosal" junction to extrapolate specific biologic landmarks around teeth and implants. Mean cervical dimensions, distance from zenith of CEJ to interdental contact, and CEJ curvature were compared. Cervical dimensions significantly differed, with a more symmetric cervical cross-section for central incisors, slightly more rectangular shape for lateral incisors, and distinctly rectangular shape for canines. CEJ curvature was statistically different between all tooth groups (centrals > laterals > canines); within groups, curvature value was always superior at the mesial aspect compared to distally (3.46 mm vs 3.13 mm for centrals, 2.97 mm vs 2.38 mm for laterals, and 2.55 mm vs 1.60 mm for canines). Tooth-implant biologic width discrepancies ranged from 4.10 to 5.96 mm and were different between all groups of teeth (centrals > laterals > canines); within groups, the discrepancy was always superior at the mesial aspect compared to distally. Current implant design featuring a flat, rotation-symmetric shoulder should be reconsidered in view of natural CEJ contour to improve biologic considerations and related esthetics.
A New Treatment for Urethral Strictures: A Permanently Implanted Urethral Stent (1989)

We describe a new urethral stent, originally developed for endovascular use, that we have implanted into 8 patients with urethral strictures. The stent is woven in the form of a tubular mesh from surgical grade stainless steel wire and is self-expanding when released from its small diameter delivery catheter. All patients have been treated successfully with a good caliber urethra visible on urethrography and direct endoscopy, and with improved urine flow rates. Mean followup of these patients is 8 months (range 6 months to 1 year). Urethroscopy had demonstrated complete epithelial covering of the implant at 4 to 6 months. Although the followup is short it seems that this simple technique may offer a lasting treatment for many urethral strictures.
Effect of condensed tannins upon body growth, wool growth and rumen metabolism in sheep grazing sulla (<i>Hedysarum coronarium</i>) and perennial pasture (1992)

SUMMARY Areas of sulla ( Hedysarum coronarium ) and pasture ( Lolium perenne/Trifolium repens/Holcus lanatus ) were grazed by young sheep (29·5–34·8 kg initial liveweight) in four experiments, and effects upon body growth, wool growth and rumen metabolism were measured. Sulla contained 40–50 g condensed tannins (CT)/kg DM, whilst the pasture contained small amounts of CT (2–6 g/kg DM). After chewing during eating, a lower proportion of total CT was readily extractable and greater proportions were protein-bound and fibre-bound. Nutritional effects attributable to CT were assessed by oral administration of polyethylene glycol (PEG), which binds and inactivates CT, to half the animals grazing each forage. Rates of body growth were consistently higher for lambs grazing sulla than those grazing pasture, with the CT concentration in sulla being neither stimulatory or inhibitory to body growth or voluntary feed intake (VFI). The action of CT reduced carcass fatness in sheep fed both diets, in the one experiment where this was measured. CT present in both sulla and pasture decreased rumen ammonia concentration and decreased molar proportions of iso-butyrate and iso and n -valerate. During spring and early summer, when wool growth rates were highest, CT present in both pasture and sulla increased wool growth rate; when wool growth rates were low during winter, CT had no effect upon the wool growth of sheep grazing either forage. Numbers of protozoa and molar proportions of n -butyrate in rumen fluid were increased by CT in sheep grazing sulla but not pasture. It was concluded that the higher rates of body growth and VFI in lambs grazing sulla was most likely to be due to its very high ratio of readily fermentable: structural carbohydrate.
Experimental Candida albicans infection in conventional mice and germfree rats (1976)

Swiss-Webster white mice were intravenously infected with various doses of Candida albicans, and the viable units in their spleens, livers, lungs, and kidneys were determined at various intervals after challenge. The results showed that C. albicans multiplied to a greater extent in the kidneys of mice than in their spleens, lungs, or livers. The infection in mice was chronic; increasing numbers of C. albicans were observed in their kidneys until about 17 to 24 days postchallenge. Clearance of C. albicans from infected kidneys was not symmetrical, since the number of viable C. albicans in one kidney did not coincide with the viable counts observed in the opposite kidney of that same animal. Male and female mice did not differ in their overall susceptibility (50% lethal dose test) or in the number of viable C. albicans in the kidneys at various time intervals after infection. C. albicans also multiplied in the kidneys of germfree rats; however, the peak of the C. albicans infection in their kidneys occurred earlier than in those of conventional mice.
Ezetimibe: a novel option for lowering cholesterol (2003)

Elevated low-density lipoprotein (LDL)-cholesterol is associated with a significantly increased risk of coronary heart disease but lowering LDL-cholesterol to levels established in current National Cholesterol Education Program (NCEP) guidelines provides significant risk reduction. Nevertheless, many patients receiving lipid-lowering therapy, particularly those at highest coronary heart disease risk, do not reach LDL-cholesterol goals with their current medications. Ezetimibe (Zetia, Merck Schering-Plough) is the first of a new class of lipid-lowering drugs known as cholesterol absorption inhibitors. Ezetimibe has a favorable pharmacokinetic profile, which allows it to be administered once daily and to be given in conjunction with statins. In a series of randomized, controlled, multicenter studies, ezetimibe produced significant improvements in levels of LDL-cholesterol and other lipid parameters when used as monotherapy, with a safety profile comparable with that of placebo. Furthermore, coadministration of ezetimibe with a statin (simvastatin, atorvastatin, lovastatin, or pravastatin) was more effective than statin monotherapy in lowering LDL-cholesterol and improving other lipid parameters. Moreover, coadministration of ezetimibe with a statin allowed a greater percentage of patients to achieve treatment goals established in NCEP guidelines. The safety and side-effect profile of ezetimibe plus statin coadministration therapy was generally comparable with that of statin monotherapy. These studies establish ezetimibe as an effective lipid-lowering agent, which will likely be useful in the management of a broad range of patients with hypercholesterolemia. Ezetimibe can be used in conjunction with a statin at the beginning of therapy, or it can be added if patients do not achieve their LDL-cholesterol goal with statins alone.
Lethal tuberculosis in interleukin-6-deficient mutant mice (1997)

Tuberculosis is a chronic infectious disease which causes major health problems globally. Acquired resistance is mediated by T lymphocytes and executed by activated macrophages. In vitro studies have emphasized the importance of macrophage activation for mycobacterial growth inhibition. In vivo, the protective host response is focused on granulomatous lesions in which Mycobacterium tuberculosis is contained. A cellular immune response of the T helper 1 (Th1) type is considered central for control of tuberculosis. Using interleukin-6 (IL-6)-deficient mice, we here demonstrate a crucial role of this pluripotent cytokine in protection against M. tuberculosis but not against Mycobacterium bovis BCG. Infection with M. tuberculosis was lethal for the IL-6-deficient mice at inocula that were still controlled by IL-6-competent mice. Spleen cells from M. tuberculosis-infected IL-6-/- mouse mutants produced elevated levels of IL-4 and reduced levels of gamma interferon compared to the control levels. Cytofluorometric analyses of spleen cells from M. tuberculosis-infected mice revealed more-profound alterations in T-cell ratios in IL-6-/- mice than in control mice. We assume that IL-6 contributes to host resistance by its proinflammatory activity and by its influence on cytokine secretion.
"Utterly content in each other's company" (2004)

In this paper I wish to examine the two related concepts of semantic prosody and semantic preference. I will begin the section on each with a definition, attempt a review of relevant current positions and then describe a number of corpus-based experiments I conducted to throw light on the two phenomena. Finally, I will try to draw some conclusions about the relationship between them.
Design of the roof for the Grandview Heights Aquatic Centre, Surrey, Canada (2017)

Constructed to meet the diverse needs of one of Canada’s fastest-growing cities, Grandview Heights Aquatic Centre features an undulating roof structure with hanging timber 'cables' suspended between large concrete buttresses. It is believed to be the world's largest-spanning pure catenary timber roof, highlighting wood's potential as a cost-effective, structurally efficient and aesthetically pleasing building material for aquatic facilities.
Semistructured and structured data in the Web: going back and forth (1997)

Database systems offer efficient and reliable technology to query structured data. However, because of the explosion of the World Wide Web, an increasing amount of information is stored in repositories organized according to less rigid structures, usually as hypertextual documents, and data access is based on browsing and information retrieval techniques. Since browsing and search engines present important limitations, several query languages for the Web have been recently proposed. These approaches are mainly based on a loose notion of structure, and tend to see the Web as a huge collection of unstructured objects, organized as a graph Clearly, traditional database techniques are of little use in this field, and new techniques need to be developed. In this paper, we present the approach to the management of Web data as attacked in the ARANEUS project carried out by the database group at University Roma Tre Our approach is based on a generalization of the notion of view to the Web framework.
Evolution and Optimum Seeking: The Sixth Generation (1993)

From the Publisher:
With the publication of this book, Hans-Paul Schwefel has responded to rapidly growing interest in Evolutionary Computation, a field that originated, in part, with his pioneering work in the early 1970s. Evolution and Optimum Seeking offers a systematic overview of both new and classical approaches to computer-aided optimum system design methods, including the new class of Evolutionary Algorithms and other Parallel Problem Solving from Nature (PPSN) methods. It presents numerical optimization methods and algorithms to computer calculations which will be particularly useful for massively parallel computers. It is the only book in the field that offers in-depth comparisons between classical direct optimization methods and the newer methods. Dr. Schwefel's method consists essentially of the adaptation of simple evolutionary rules to a computer procedure in the search for optimal parameters within a simulation model of a technical device. In addition to its historical and practical value, Evolution and Optimum Seeking will stimulate further research into PPSN and interdisciplinary thinking about multi-agent self-organization in natural and artificial environments. These developments have been accelerated by fortunate changes in the computational environment, especially with respect to new architectures. MIMD (Multiple Instructions Multiple Data) machines with many processors working in parallel on one task seem to lend themselves to inherently parallel problem solving concepts like Evolution Strategies. The most comprehensive work of its kind, Evolution and Optimum Seeking offers a state-of-the-art perspective on the field for researchers in computer-aided design, planning, control, systems analysis, computational intelligence, and artificial life. Its range and depth make it a virtual handbook for practitioners: epistemological introduction to the concepts and strategies of optimum seeking; taxonomy of optimization tasks and solution principles (material found n
Network-based mobility and Host Identity Protocol (2012)

The current use of IP address in network application session identification cannot preserve the session when the IP address changes. Host Identity Protocol (HIP), which is an identity-location separation protocol, provides a better framework to build solutions for mobility, multihoming, and security by adding a host identity layer on top of the IP layer. Yet modifying the IP protocol stack and adding mobility as well as other solutions to all the hosts can be impractical to deploy and interoperate with existing IP hosts. This paper proposes a network-based HIP service as well as mobility solution at HIP layer to all mobile hosts. The network-based service includes tracking mobile hosts, assigning network prefix per host identifier, securely updating the binding of mobile hosts, and providing a HIP proxy function to ensure the delivery of the same IP prefix to the mobile host during handover in the same network domain. Better handover performance in terms of handover latency and signaling overheard is achieved, when compared with proxy mobile IP or existing purely HIP-based mobility protocol.
Preparation of a Cationic Azobenzene Derivative−Montmorillonite Intercalation Compound and the Photochemical Behavior (1996)

The intercalation of a cationic azobenzene derivative, p-(ω-(trimethylammonio)pentyloxy)-p‘-(dodecyloxy)azobenzene bromide, into montmorillonite and the photochemical reaction of the intercalated dye have been investigated. The adsorbed azo dye cations form the head-to-tail aggregates in the interlayer space of montmorillonite and exhibit reversible trans-to-cis photoisomerization by UV irradiation and the subsequent thermal treatment.
Experimental performance analysis of two-hop aerial 802.11 networks (2014)

Small-scale multicopters operating as autonomous teams in the air are envisioned for aerial monitoring and transport of goods in a variety of applications, including disaster management and environmental monitoring. For such applications to become reality, a high-throughput wireless network is needed. This paper presents experimental performance results with commercially available quadrocopters communicating via IEEE 802.11a. In particular, we compare the infrastructure and mesh modes of 802.11 for one-hop and two-hop communications, thus analyzing network layer versus MAC layer relaying. Results illustrate that changes are required in the mesh mode to support applications demanding high throughput with low jitter.
James H Nicoll: pioneer paediatric surgeon. (1997)

James H Nicoll is a little known figure in the history of surgery. Yet, this Glasgow surgeon was a pioneer, particularly in the care of the infant patient both in hospital and after discharge. A great teacher and innovator, he developed effective techniques for the surgical cure of pyloric stenosis of infancy and for the outpatient postoperative care of children with spina bifida.
COVID-19 as the Pied piper (2020)

Digital cartoon by Guy Body on political and social issues in New Zealand. 
Title supplied by Library. 
Quantity: 1 digital cartoon(s).
Minimum bit-error rate design for space-time equalization-based multiuser detection (2006)

A novel minimum bit-error rate (MBER) space-time-equalization (STE)-based multiuser detector (MUD) is proposed for multiple-receive-antenna-assisted space-division multiple-access systems. It is shown that the MBER-STE-aided MUD significantly outperforms the standard minimum mean-square error design in terms of the achievable bit-error rate (BER). Adaptive implementations of the MBER STE are considered, and both the block-data-based and sample-by-sample adaptive MBER algorithms are proposed. The latter, referred to as the least BER (LBER) algorithm, is compared with the most popular adaptive algorithm,known as the least mean square (LMS) algorithm. It is shown that in case of binary phase-shift keying, the computational complexity of the LBER-STE is about half of that required by the classic LMS-STE. Simulation results demonstrate that the LBER algorithm performs consistently better than the classic LM Salgorithm, both in terms of its convergence speed and steady-state BER performance.
Erythropoietin and Erythropoietin Receptor Expression after Experimental Spinal Cord Injury Encourages Therapy by Exogenous Erythropoietin (2005)

These observations suggest that the local EPO and EPO-R system is markedly engaged in the early stages after nervous tissue injury. The reduction in EPO immunoexpression and the increase in EPO-R staining strongly support the possible usefulness of a therapeutic approach based on exogenous EPO administration.
Design and optimization of a Permanent Magnet Transverse Flux Machine (2012)

This paper presents the design and optimization of a Permanent Magnet Transverse Flux Machine. The design procedure takes into account a script-based, 3D Finite Elements simulation and some additional analytical equations to obtain the full performance of the machine. A Genetic Algorithm optimization method is used in order to achieve the best possible relationship among mechanical power, efficiency and volume. The results will be compared to the actual machine.
Farnesol production in <i>Escherichia coli</i> through the construction of a farnesol biosynthesis pathway – application of PgpB and YbjG phosphatases (2016)

Farnesol is a sesquiterpenoid alcohol that has important industrial and medical potential. It is usually synthesized from farnesyl diphosphate (FPP) by farnesol synthase in plants. FPP accumulation can cause up-regulation of phosphatases capable of FPP hydrolysis, resulting in farnesol production in Escherichia coli. We found that PgpB and YbjG, two integral membrane phosphatases, can hydrolyze FPP into farnesol. Overexpression of FPP synthase (IspA) and PgpB, along with a heterologous mevalonate pathway, enabled recombinant E. coli to produce 526.1 mg/L of farnesol. This result indicates that the phosphatases PgpB and YbjG can be used to construct a novel farnesol synthesis pathway for mass production in E. coli.
Defective lysosomal arginine transport in juvenile Batten disease (2005)

Mutations in the CLN3 gene, which encodes a lysosomal membrane protein, are responsible for the neurodegenerative disorder juvenile Batten disease. A previous study on the yeast homolog to CLN3, designated Btn1p, revealed a potential role for CLN3 in the transport of arginine into the yeast vacuole, the equivalent organelle to the mammalian lysosome. Lysosomes isolated from lymphoblast cell lines, established from individuals with juvenile Batten disease-bearing mutations in CLN3, but not age-matched controls, demonstrate defective transport of arginine. Furthermore, we show that there is a depletion of arginine in cells derived from individuals with juvenile Batten disease. We have, therefore, characterized lysosomal arginine transport in normal lysosomes and show that it is ATP-, v-ATPase- and cationic-dependent. This and previous studies have shown that both arginine and lysine are transported by the same transport system, designated system c. However, we report that lysosomes isolated from juvenile Batten disease lymphoblasts are only defective for arginine transport. These results suggest that the CLN3 defect in juvenile Batten disease may affect how intracellular levels of arginine are regulated or distributed throughout the cell. This assertion is supported by two other experimental approaches. First, an antibody to CLN3 can block lysosomal arginine transport and second, expression of CLN3 in JNCL cells using a lentiviral vector can restore lysosomal arginine transport. CLN3 may have a role in regulating intracellular levels of arginine possibly through control of the transport of this amino acid into lysosomes.