gebhart/patrepeval huggingface dataset:
Crawler Technology Based on Scrapy Framework (2019)

Abstract With the development of the times and the popularization of scientific and technological products, the Internet has become inseparable from our lives, and search engines have become a daily necessity of people.In view of the growing needs 。This topic requires the design of a prototype crawler system based on Scrapy framework. The specific requirements and contents are as follows: analyzing the structure and rules of the target website, looking for data items that need to be crawled. Based on Scrappy framework, a crawler prototype program is implemented by customizing crawling rules.Select the appropriate database for data access and analysis.
A measurement-based analysis of multihoming (2003)

Multihoming has traditionally been employed by stub networks to enhance the reliability of their network connectivity. With the advent of commercial "intelligent route control" products, stubs now leverage multihoming to improve performance. Although multihoming is widely used for reliability and, increasingly for performance, not much is known about the tangible benefits that multihoming can offer, or how these benefits can be fully exploited. In this paper, we aim to quantify the extent to which multihomed networks can leverage performance and reliability benefits from connections to multiple providers. We use data collected from servers belonging to the Akamai content distribution network to evaluate performance benefits from two distinct perspectives of multihoming: high-volume content-providers which transmit large volumes of data to many distributed clients, and enterprises which primarily receive data from the network. In both cases, we find that multihoming can improve performance significantly and that not choosing the right set of providers could result in a performance penalty as high as 40%. We also find evidence of diminishing returns in performance when more than four providers are considered for multihoming. In addition, using a large collection of measurements, we provide an analysis of the reliability benefits of multihoming. Finally, we provide guidelines on how multihomed networks can choose ISPs, and discuss practical strategies of using multiple upstream connections to achieve optimal performance benefits.
A neoadjuvant clinical trial in colorectal cancer patients of the human anti-idiotypic antibody 105AD7, which mimics CD55. (2000)

Thirty-five patients received 105AD7 human anti-idiotype vaccination prior to surgery for colorectal carcinoma. Patients were immunized before and also received one to two immunizations after surgical resection of their colorectal cancer. The vaccine was well tolerated with no associated toxicity. Lymphocytic infiltration within the resected tumors was quantified by immunohistochemistry and image analysis. Enhanced infiltration of helper T cells (CD4) and natural killer (NK) cells (CD56) were observed in the tumors from immunized patients when compared with tumors from stage, grade, site, age, and sex matched unimmunized patients. NK activity was increased in the blood, peaking 7-10 days post immunization and then dropping rapidly and correlating with NK extravasation within the tumor. Comparison of the amino acid sequences of 105AD7 anti-idiotype and the antigen it mimics, CD55, has predicted that patients with HLA-DR1, HLA-DR3, and HLA-DR7 haplotypes should show helper T cell responses following 105AD7 vaccination. Eighty-three percent of patients expressing these haplotypes responded to 105AD7, whereas 88% of patients who failed to express these haplotypes were nonresponders. With a median follow-up of 4 years (range, 2.5-6 years) 65% of patients remained disease free. This trial shows that 105AD7 stimulates antitumor inflammatory responses allowing extravasation within tumor deposits of both helper T cells and NK cells. This represents a way of evaluating immune responses in patients both within the blood and at the tumor site. The study confirms that immunization with a human anti-idiotypic antibody results in immune responses in 83% of patients with a permissive haplotype.
Enabling Cell-Free Massive MIMO Systems With Wireless Millimeter Wave Fronthaul (2022)

Cell-free massive MIMO systems have promising data rate and coverage gains. These systems, however, typically rely on fiber based fronthaul for the communication between the central processing unit and the distributed access points (APs), which increases the infrastructure cost and installation complexity. To address these challenges, this paper proposes two architectures for cell-free massive MIMO systems based on wireless fronthaul that is operating at a higher-band compared to the access links. These dual-band architectures ensure high data rate fronthaul while reducing the infrastructure cost and enhancing the deployment flexibility and adaptability. To investigate the achievable data rates with the proposed architectures, we formulate the end-to-end data rate optimization problem accounting for the various practical aspects of the fronthaul and access links. Then, we develop a low-complexity yet efficient joint beamforming and resource allocation solution for the proposed architectures based on user-centric AP grouping. With this solution, we show that the proposed architectures can achieve comparable data rates to those obtained with optical fiber-based fronthaul under realistic assumptions on the fronthaul bandwidth, hardware constraints, and deployment scenarios. This highlights a promising path for realizing the cell-free massive MIMO gains in practice while reducing the infrastructure and deployment overhead.
Development of a 128-channel multi-water-sampling system for underwater platforms and its application to chemical and biological monitoring (2013)

We developed a new multi-water-sampling system, ANEMONE-11, for autonomous underwater vehicle and remotely operated underwater vehicle exploration. Water samples are continuously collected by the ANEMONE-11 sampler by an in situ water pump at 40 mL/min and are sent to a selection valve unit that consists of 128 valves connected to 40 mL sampling bottles (50 cm in length). Each valve in the unit is selected and opened at preprogrammed intervals. We also discuss the results of observations at a hydrothermal area in the Okinawa Trough.
Asymmetric epoxidation provides shortest routes to four chiral epoxy alcohols which are key intermediates in syntheses of methymycin, erythromycin, leukotriene C-1, and disparlure (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric epoxidation provides shortest routes to four chiral epoxy alcohols which are key intermediates in syntheses of methymycin, erythromycin, leukotriene C-1, and disparlureBryant E. Rossiter, Tsutomu Katsuki, and K. Barry SharplessCite this: J. Am. Chem. Soc. 1981, 103, 2, 464–465Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/ja00392a038https://doi.org/10.1021/ja00392a038research-articleACS PublicationsRequest reuse permissionsArticle Views3329Altmetric-Citations311LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Three-Way Conversion Catalysts: Effect of Closed-Loop Feed-Back Control and Other Parameters on Catalyst Efficiency (1980)

<div class="htmlview paragraph">Monolithic three-way conversion (TWC) catalysts, at different precious metal concentrations, were aged on an engine dynamometer with fuel doped with lead (0.012 g Pb/gal). These catalysts were subsequently evaluated on an engine dynamometer to examine the effects of air/fuel ratio set point, temperature, and air/fuel ratio amplitude and frequency on the conversion efficiencies for NO<sub>x</sub> CO and HC. In all evaluations, as the precious metal concentration increased from 5 g/ft<sup>3</sup> to 40 g/ft<sup>3</sup>, the NO<sub>x</sub> CO and HC conversions increased. Also, the smallest effect of precious metal loading on catalyst efficiency was found at the smallest air/fuel amplitude (±0.3 A/F). The highest overall conversions of NO<sub>x</sub> CO and HC were obtained at the stoichiometric control point for perturbations of ±0.3 A/F amplitude. Therefore, it appears that a considerable savings in precious metals can be realized if the A/F amplitude of a closed-loop feed-back control system is small (±0.3 A/F). On the other hand, the higher the oscillation frequency of the feed-back control system, the higher the NO<sub>x</sub> CO and HC conversions. Thus, an additional savings in precious metals may be achieved if the control frequency is increased. Since the A/F perturbation amplitude and frequency, catalyst temperature range, A/F control point, and catalyst precious metal concentration all combine to affect the NO<sub>x</sub> CO and HC conversion efficiency, the selection of the precious metal loading of the TWC catalyst, the catalyst strategy (single or dual-bed system), and the A/F set point largely depend on the characteristics of the feed-back control system and the concentration of NO<sub>x</sub> CO and HC emissions from the engine.</div>
Heading Estimation Based on Magnetic Markers for Intelligent Vehicles (2016)

This paper presents a new real-time heading estimation method for an all-wheel steered single-articulated autonomous vehicle guided by a magnetic marker system. To achieve good guidance control for the vehicle, precise estimation of the position and heading angle during travel is necessary. The main concept of this study is to estimate the heading angle from the relative orientations of the magnetic markers and the vehicle motion. To achieve this, a kinematic model of the all-wheel steered vehicle is derived and combined with the motion of a magnetic ruler mounted near each axle underneath the vehicle. The position coordinates and polarities of the magnetic markers, which are provided a priori, are used to determine the vehicle position at every detection instance. A gyroscope is employed to assist real-time heading estimation at sample times when there are no marker detection data. The proposed method was tested on a real vehicle and evaluated by comparing the experimental results with those of the differential global positioning system (DGPS) in real-time kinematics (RTK) mode. Experimental results show that the proposed method exhibits good performance for heading estimation.
Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing (2009)

Delta9-Tetrahydrocannabinol and CBD had clearly distinct effects on the neural, electrodermal, and symptomatic response to fearful faces. The effects of CBD on activation in limbic and paralimbic regions may contribute to its ability to reduce autonomic arousal and subjective anxiety, whereas the anxiogenic effects of Delta9-THC may be related to effects in other brain regions.
Electric Power Distribution Handbook (2003)

Of the ...big three... components of the electricity infrastructure, distribution typically gets the least attention, and no thorough, up-to-date treatment of the subject has been published in years. Filling that void, the Electric Power Distribution Handbook provides comprehensive information on the electrical aspects of power distribution systems
Synthesis and Antiproliferative Evaluation of Certain Indeno[1,2-<i>c</i>]quinoline Derivatives. Part 2 (2010)

Certain indeno[1,2-c]quinoline derivatives were synthesized and evaluated for their antiproliferation, DNA binding affinity, and topoisomerases (topo I and topo II) inhibitory activities. The preliminary results are the following: (1) substituent of the aminoalkoxyimino side chain at C11 is important for antiproliferative activities in which the terminal amine preferred to be a tertiary or the cyclic five-membered pyrrolidino ring; (2) among the indeno[1,2-c]quinoline derivatives evaluated, (E)-6-hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-11-one O-2-(pyrrolidin-1-yl)ethyl oxime (8c) was found to be one of the most cytotoxic agents with a GI50 value of 0.84, 0.89, and 0.79 microM against SAS, A549, and BT483, respectively, which is more active than camptothecin; (3) substituent at C6 is crucial for the selective cytotoxicity in which the OH group is the most preferred while hydrogen or piperazine exhibited cytotoxicity on both cancer cells and Detroit-551; (4) a positive correlation of antiproliferative activity, DNA binding affinity, and topo I and topo II inhibitory activities has been observed for indeno[1,2-c]quinoline derivatives; (5) compound 8c induced DNA fragmentation may through caspase-3 activation, phosphorylation of the histone protein H2AX at Ser139 (gamma-H2AX), and PARP cleavage; (6) compound 8c demonstrated significant tumor regression in the human breast xenograft model; (7) indeno[1,2-c]quinoline derivatives are a new class of molecules that have the potential to be developed as dual topo I and topo II inhibitory agents.
Plasmon-based photosensors comprising a very thin semiconducting region (2009)

We theoretically investigate an elementary subwavelength plasmonic sensor comprising a very thin active region. High quantum efficiency (QE), broad spectral band and nearly no sensitivity to the incidence angle and polarization can be achieved. We particularly discuss different examples based on HgCdTe for infrared detection: QEs of 75% are obtained for active layers λ/(8n) thin, corresponding to a tenfold absorption enhancement.
Pre-Trained and Attention-Based Neural Networks for Building Noetic Task-Oriented Dialogue Systems (2020)

The NOESIS II challenge, as the Track 2 of the 8th Dialogue System Technology Challenges (DSTC 8), is the extension of DSTC 7. This track incorporates new elements that are vital for the creation of a deployed task-oriented dialogue system. This paper describes our systems that are evaluated on all subtasks under this challenge. We study the problem of employing pre-trained attention-based network for multi-turn dialogue systems. Meanwhile, several adaptation methods are proposed to adapt the pre-trained language models for multi-turn dialogue systems, in order to keep the intrinsic property of dialogue systems. In the released evaluation results of Track 2 of DSTC 8, our proposed models ranked fourth in subtask 1, third in subtask 2, and first in subtask 3 and subtask 4 respectively.
A framework for combined bayesian analysis and optimization for services delivery (2009)

One of the key challenges facing the professional services delivery business is the issue of optimally balancing competing demands from multiple, concurrent engagements on a limited supply of skill resources. In this paper, we present a framework for combining causal Bayesian analysis and optimization to address this challenge. Our framework integrates the identification and modeling of the impact of various staffing factors on the delivery quality of individual engagements, and the optimization of the collective adjustments of these staffing factors, to maximize overall delivery quality for a pool of engagements. We describe a prototype system built using this framework and actual services delivery data from IBM's IT consulting business. System evaluation under realistic scenarios constructed using historical delivery records provides encouraging evidence that this framework can lead to significant delivery quality improvements. These initial results further open up exciting opportunities of additional future work in this area, including the integration of temporal relationships for causal learning and multi-period optimization to address more complex business scenarios.
Treatment of polyomavirus infection with cidofovir in a renal-transplant recipient (2002)

60–70% ofhealthy adults are serologically positive) [1]. Recently,there has been an increased awareness of BK-virusnephropathy (BKN) as a new complication affectingrenal allografts and causing graft dysfunction. Mani-festations of the disease in renal-transplant recipientsinclude interstitial nephritis, ureteric stenosis, renaldysfunction, and in extreme cases graft loss [2–4].Distinction of polyomavirus infection from acute allo-graft rejection is of particular importance and mayrepresent a diagnostic challenge. Patients at risk ofBKN are diagnosed by the presence of intranuclearviral inclusion bodies in cells shed in urine and inrenal epithelial cells (‘decoy cells’). Molecular diag-nosis based on real-time quantitative polymerasechain reaction (Q-PCR) on urineublood strengthensthe suspicion. Final diagnosis is made by speciﬁcﬁndings in the allograft biopsy, in particular positiveimmunohistochemical staining for viral proteins.There is a possible association between the useof tacrolimus (Prograf
THE DECREASED BASAL AND STIMULATED PROLACTIN LEVELS IN ISOLATED GONADOTROPHIN DEFICIENCY: A CONSEQUENCE OF THE LOW OESTROGEN STATE (1982)

Prolactin secretion has been evaluated in seven male and six female patients with isolated gonadotrophin deficiency (IGD). The subjects were challenged with the dopaminergic antagonist, metoclopramide (10 mg) and TRH (200 μg) before, during and after cessation of hormonal treatment. Five females received three consecutive 21‐day courses of ethinyl oestradiol (0·1 mg daily) at monthly intervals and the remaining subject conjugated oestrogens (Premarin 0·625 mg daily) according to a similar protocol. Treatment of the males with hCG (pregnyl) 5000 iu twice weekly led to a rise in oestradiol and testosterone levels. Two males were receiving pergonal (human menopausal gonadotrophin) in addition. In the untreated state in both males and females, basal oestradiol and PRL levels were decreased as were the PRL responses to metoclopramide and TRH as compared with normal controls. During treatment in both groups, there was an increase in basal PRL levels as well as PRL response to the two stimuli, which became indistinguishable from the controls. Cessation of treatment was associated with a rapid decrease in basal PRL levels and PRL elevation following metoclopramide and TRH. In contrast to the effect of hCG, the administration of two non‐aromatizable androgens (mesterolone and fluoxymesterone) had no effect on basal and TRH‐induced PRL secretion. The administration of clomiphene citrate during hCG treatment in one male IGD patient produced a decrease in the basal and stimulated PRL response. It is concluded that the low basal PRL levels and impaired PRL responses to stimulation are not an inherent component of the syndrome of IGD, but a consequence of the abnormal steroid milieu.
Authorship clustering using multi-headed recurrent neural networks (2016)

A recurrent neural network that has been trained to separately model the language of several documents by unknown authors is used to measure similarity between the documents. It is able to find clues of common authorship even when the documents are very short and about disparate topics. While it is easy to make statistically significant predictions regarding authorship, it is difficult to group documents into definite clusters with high accuracy.
Does Vitamin E Supplementation Prevent Cardiovascular Events? (2003)

In recent years, vitamin E has been investigated as a cardioprotective agent. Experimental studies have identified potential mechanisms by which vitamin E may inhibit the development of atherosclerosis, and observational studies of individuals without coronary disease suggest that vitamin E intake may prevent future cardiovascular events. Secondary prevention trials to date have demonstrated little benefit from vitamin E supplementation. It remains possible, however, that supplementation may be useful among certain high-risk groups, including those with nutritional deficiencies. Limited data from completed primary prevention trials also indicate minimal cardioprotection from vitamin E, but large-scale trials now in progress may yet show benefit. Results from ongoing trials will contribute powerfully to the totality of evidence on which to formulate both appropriate clinical recommendations for individual patients and a rational public health policy for the population as a whole. At this time, there is insufficient evidence for issuing a public health recommendation to use vitamin E supplements to prevent cardiovascular disease (CVD). Rather, increased intake of fruits, vegetables, and other antioxidant-rich foods should be promoted as part of a healthy diet because they provide nutritional benefits beyond any potential antioxidant effect. Moreover, even if found to reduce CVD risk, vitamin supplement use should be considered an adjunct, not an alternative, to established cardioprotective measures, such as smoking abstention, avoidance of obesity, adequate physical activity, and control of high blood pressure and hyperlipidemia.
Efficient CRISPR-mediated base editing in <i>Agrobacterium</i> spp. (2020)

<i>Agrobacterium</i> spp. are important plant pathogens that are the causative agents of crown gall or hairy root disease. Their unique infection strategy depends on the delivery of part of their DNA to plant cells. Thanks to this capacity, these phytopathogens became a powerful and indispensable tool for plant genetic engineering and agricultural biotechnology. Although <i>Agrobacterium</i> spp. are standard tools for plant molecular biologists, current laboratory strains have remained unchanged for decades and functional gene analysis of <i>Agrobacterium</i> has been hampered by time-consuming mutation strategies. Here, we developed clustered regularly interspaced short palindromic repeats (CRISPR)-mediated base editing to enable the efficient introduction of targeted point mutations into the genomes of both <i>Agrobacterium tumefaciens</i> and <i>Agrobacterium rhizogenes</i> As an example, we generated EHA105 strains with loss-of-function mutations in <i>recA</i>, which were fully functional for maize (<i>Zea mays</i>) transformation and confirmed the importance of RolB and RolC for hairy root development by <i>A. rhizogenes</i> K599. Our method is highly effective in 9 of 10 colonies after transformation, with edits in at least 80% of the cells. The genomes of EHA105 and K599 were resequenced, and genome-wide off-target analysis was applied to investigate the edited strains after curing of the base editor plasmid. The off-targets present were characteristic of Cas9-independent off-targeting and point to TC motifs as activity hotspots of the cytidine deaminase used. We anticipate that CRISPR-mediated base editing is the start of "engineering the engineer," leading to improved <i>Agrobacterium</i> strains for more efficient plant transformation and gene editing.