gebhart/patrepeval huggingface dataset:
δ-crystallin enhancer binding protein δEF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis (1993)

We investigated nuclear factors that bind to delta 1-crystallin enhancer core and regulate lens-specific transcription. A nuclear factor delta EF1, which binds to the essential element of the delta 1-crystallin enhancer core, was molecularly cloned from the chicken by a southwestern method. The protein organization of delta EF1 deduced from the cDNA sequence indicated that it has heterogeneous domains for DNA-binding, two widely separated zinc fingers and a homeodomain, analogous to Drosophila ZFH-1 protein. The C-terminal zinc fingers were found to be responsible for binding to the delta 1-crystallin enhancer core sequence. delta EF1 had proline-rich and acidic domains common to various transcriptional activators. During embryogenesis, delta EF1 expression was observed in the postgastrulation period in mesodermal tissues; initially, in the notochord, followed by somites, nephrotomes and other components. The expression level changed dynamically in a tissue, possibly reflecting the differentiation states of the constituent cells. Besides mesoderm, delta EF1 was expressed in the nervous system and the lens, but other ectodermal tissues and endoderm remained very low in delta EF1 expression. Cotransfection experiments indicated that this factor acts as a repressor of delta 1-crystallin enhancer. Possession of heterogeneous DNA-binding domains and its dynamic change of expression in embryogenesis strongly suggest that delta EF1 acts in multiple ways depending on the cell type and the gene under its regulation.
Affective Haptics: Current Research and Future Directions (2015)

Touch plays a prominent role in communicating emotions and intensifying interpersonal communication. Affective haptics is an emerging field, which focuses on the analysis, design, and evaluation of systems that can capture, process, or display emotions through the sense of touch. The objective of this paper is to present an overview of the recent achievements in affective haptics and to discuss how the sense of touch can elicit or influence human emotions. We first introduce a definition to the term affective haptics and describe its multidisciplinary nature-as a field that integrates ideas from affective computing, haptic technology, and user experience. Second, we provide a thorough discussion about the effectiveness of using the haptic channel to communicate affective information through direct and mediated means. Third, we present a variety of applications in the area ranging from interhuman social interaction systems to human robot interaction applications. Finally, we discuss some of the key findings discerned from the various surveyed papers, and present some of the challenges and trends in this field. We extract the following conclusions pertaining to affective haptics: 1) haptic stimulation can be successfully used to achieve a higher level of emotional immersion during media consumption or emotional telepresence; 2) existing research has demonstrated that haptics is effective in communicating valence and arousal, and the emotions of happiness, sadness, anger and fear, and less focus have been given to the communication of disgust and surprise; 3) the haptic-based affect detection remains an understudied topic, whereas the haptic-based affect display is a well-established subject; and 4) the interpretation of the haptic stimulation by human beings is highly contextual.
Implementation of a window-based scheduler in an ATM switch (2002)

ATM networks have to handle a wide range of traffic characteristics and performance requirements. The transmission control scheme should regulate the flow of packets from the switching queues to the outgoing links. The quality of service (QoS) requirements can be provided by delivering the cell within a maximum predetermined delay and without exceeding the maximum limit of allowable cell loss. We propose a switching scheme to satisfy different QoS requirements. The basic buffering component of the switch is a virtual dual-ported memory shared by all input and output lines. Cells arriving on input lines are stored to the common memory. The memory is divided into multiple priority queues to handle different classes of services. Cells are simultaneously retrieved from the priority queues and transmitted over the output lines. The higher priority queues can send a predefined number of cells before the lower priority queues are serviced in order to maintain the Qos of each class. The architecture of the switch is described. A simulation for the switch is run to show the effect of the scheduling protocol on the performance metrics.
Bases Defining an Ammonium and Magnesium Ion-Dependent Tertiary Structure Within the Large Subunit Ribosomal RNA (1994)

A 58 nucleotide RNA derived from a highly conserved domain of the large subunit ribosomal RNA (Escherichia coli 1051 to 1108) has a set of tertiary interactions that is stabilized by NH4+ and Mg2+ in preference to other ions. We have mapped the nucleotides contributing to this structure by examining the thermal denaturation of 25 sequence variants. Where necessary compensatory mutations were made to preserve the phylogenetically conserved secondary structure. Substitutions of bases or base-pairs at eight positions specifically eliminate the ion-dependent tertiary structure without affecting the secondary structure stability; most of these positions are conserved among all large subunit RNA sequences. At two positions, substitutions of bases found in other organisms stabilize the E. coli tertiary structure by substantial amounts (delta G 37 degrees becomes more favorable by -1.8 to -4.5 kcal/mol). One of these variants disrupts a potential A.U base-pair within a helix, suggesting that the tertiary structure competes with alternative structures. The results show that this rRNA domain contains an extensive, highly conserved, and very stable set of tertiary interactions. The sequence in E. coli, and probably most other organisms, has not evolved to maximum stability. It is possible that natural selection has "tuned" the tertiary structure to an optimum stability, perhaps because the structure must open and close during the ribosome cycle.
Asocial and afraid: An examination of shyness and anxiety in emerging adulthood (2013)

Shy emerging adults report greater internalizing behaviors and lower quality close relationships, but fewer externalizing behaviors (Nelson et al., 2008). Although multiple forms of children’s and adolescents' social withdrawal have been identified, such as social fearfulness and social disinterest (withdrawal, but no fear; e.g., Coplan & Rubin, 2010), less work has been done to examine emerging adults’ multiple forms of withdrawal. Therefore, we conducted an online study of emerging adults (N = 813) at five American colleges and universities (57% women; 73% European American), and identified 29 asocial, 57 shy, and a comparison group of 314 emerging adults. Results indicated that shy- anxious emerging adults experienced the worst levels of adjustment; thus, being shy and anxious may impede important developmental tasks ofemerging adulthood, such as settling on one’s religious beliefs, developing an identity, and developing quality relationships with others (peers and parents).
Reuse of Neural Modules for General Video Game Playing (2016)

A general approach to knowledge transfer is introduced in which an agent controlled by a neural network adapts how it reuses existing networks as it learns in a new domain. Networks trained for a new domain can improve their performance by routing activation selectively through previously learned neural structure, regardless of how or for what it was learned. A neuroevolution implementation of this approach is presented with application to high-dimensional sequential decision-making domains. This approach is more general than previous approaches to neural transfer for reinforcement learning. It is domain-agnostic and requires no prior assumptions about the nature of task relatedness or mappings. The method is analyzed in a stochastic version of the Arcade Learning Environment, demonstrating that it improves performance in some of the more complex Atari 2600 games, and that the success of transfer can be predicted based on a high-level characterization of game dynamics.
Induction of experimental autoimmune thyroiditis by heat-denatured porcine thyroglobulin: a Tc1-mediated disease (1999)

Recent studies have shown that denatured exogenous antigens can prime cytotoxic T lymphocytes (CTL). To assess the contribution of CTL to experimental autoimmune thyroiditis (EAT), porcine thyroglobulin (pTg) was heat-denatured (hdpTg) and injected i.v. into CBA/J mice, without the aid of adjuvants. Both lymphocytic infiltrations of the thyroid glands and levels of Tg-specific CTL were similar to those found in conventional EAT induced by Tg and adjuvants. In contrast, proliferative responses could not be detected, and titers of antibodies to pTg were 20 times lower. These EAT-inducer CTL belong to the CD8+ cell subset and exerted their thyroiditogenic potential through release of IFN-gamma. We conclude that hdpTg-induced EAT is mediated by type 1 cytotoxic T cells (Tc1).
RC-triggered pnp and NPN simultaneously switched silicon controlled rectifier ESD networks for sub-0.18μm technology (2005)

Silicon controlled rectifiers (SCRs) have superior ESD performance and are expected to play a major role in sub-/spl mu/m technologies replacing MOSFET-based ESD networks due to MOSFET dielectric scaling. In this paper, novel polysilicon-bound SCR-based clamp circuit is explored that provide simultaneous triggering of NPN and PNP bipolar transistors by means of RC discriminator network and a triggering circuit stages coupled into the regenerative feedback loop of the SCR. This network demonstrates good ESD performance, low on-resistance, high I/sub t2/ and low holding voltage.
Evaluation of a disposable, nonelectronic, patient-controlled-analgesia device for postoperative pain. (1987)

The safety and efficacy of a disposable, nonelectronic, patient-controlled-analgesia (PCA) device for alleviating postoperative pain were evaluated. Patients who were to undergo abdominal surgical procedures under general anesthesia were instructed in the use of the Travenol Infusor with Patient Control Module. Patients used the PCA device upon emerging from anesthesia in the recovery room. The PCA device delivered a 1-mg i.v. injection of morphine sulfate upon patient demand, with a relative delay of six minutes between allowable administrations. Nursing staff evaluated pain and sedation every four hours using a five-point scale. In the 50 patients evaluated, the highest analgesic use occurred during the first four to eight postoperative hours. After the immediate postoperative period, patients experienced either mild or no pain during approximately 90% of the evaluation periods. No patient suffered respiratory depression during self-dosing. Results of a poststudy self-assessment questionnaire showed that 90% of the patients reported experiencing mild to moderate pain overall, and 78% reported only mild discomfort throughout the postoperative period. Ninety-two percent of the patients strongly preferred PCA therapy over intramuscular injections. The Travenol Infusor with Patient Control Module represents a safe and effective device for PCA therapy of postoperative pain.
Sequence analysis of an 81 kb contig from Arabidopsis thaliana chromosome III (1996)

The nucleotide sequence of a 81 493 bp contig from Arabidopsis thaliana chromosome III has been determined together with 11 corresponding cognate cDNAs. Analysis of the finished sequence and comparison with public databases indicates a gene density of one gene per 4527 bp and identifies 17 novel genes, 10 of which are totally unknown or have no well-defined function. In addition, the contig contains part of a non-LTR retrotransposon and large direct and inverted repeats. Contig analysis also provides information on the structure and genomic organization of plant genes.
Wearable grain silo working environment sensing and safety alarm system (2022)

<p>A set of wearable granary working environment sensing and security alarm system is developed to ensure the safety of granary staff. The gas sensor, piezoelectric ceramic chip, infrared transmitting and receiving tube and photosensitive resistance are used as the core components of each circuit module to collect the gas concentration signal, human respiration intensity signal, pulse intensity signal and light signal in the granary. AD0809 module chip is used to convert analog data into digital data and send it to MCU for information processing to make alarm judgment. At the same time, PTR2000 module is used to transmit the sensor data to the upper computer. The upper computer determines whether to alarm through data comparison, and transmits the alarm signal to the mobile phone through Wi-Fi in real time. Each module cooperates with each other, information real-time transmission to complete the detection of granary environment and danger alarm. The test results show that the system can meet the safety operation requirements of large and medium-sized state-owned grain depot.</p>
Extracting Vehicle Sensor Signals from CAN Logs for Driver Re-identification (2019)

Data is the new oil for the car industry. Cars generate data about how they are used and who’s behind the wheel which gives rise to a novel way of profiling individuals. Several prior works have successfully demonstrated the feasibility of driver re-identification using the in-vehicle network data captured on the vehicle’s CAN (Controller Area Network) bus. However, all of them used signals (e.g., velocity, brake pedal or accelerator position) that have already been extracted from the CAN log which is itself not a straightforward process. Indeed, car manufacturers intentionally do not reveal the exact signal location within CAN logs. Nevertheless, we show that signals can be efficiently extracted from CAN logs using machine learning techniques. We exploit that signals have several distinguishing statistical features which can be learnt and effectively used to identify them across different vehicles, that is, to quasi ”reverse-engineer” the CAN protocol. We also demonstrate that the extracted signals can be successfully used to re-identify individuals in a dataset of 33 drivers. Therefore, not revealing signal locations in CAN logs per se does not prevent them to be regarded as personal data of drivers.
A/MS benchmark circuits for comparing fault simulation, DFT, and test generation methods (2017)

The ITC'97 analog and mixed-signal (A/MS) benchmark circuits have been available for two decades. This paper discusses why they were useful but not for comparing A/MS design-for-test (DFT) techniques, tests, or fault coverage. First, this paper discusses these and other benchmark circuits, and proposes objectives for better benchmark circuits. The paper then describes the first, publicly-available A/MS benchmark circuits that include realistic process models with corners, SPICE netlists for commonly used A/MS and digital cells, performance specifications, and testbenches. These facilitate publishable comparison of mixed-signal DFT, test, and fault simulation techniques to facilitate improvement for A/MS circuitry, hopefully faster than in the last two decades.
A High Power Density Integrated Charger for Electric Vehicles with Active Ripple Compensation (2015)

This paper suggests a high power density on-board integrated charger with active ripple compensation circuit for electric vehicles. To obtain a high power density and high efficiency, silicon carbide devices are reported to meet the requirement of high-switching-frequency operation. An integrated bidirectional converter is proposed to function as AC/DC battery charger and to transfer energy between battery pack and motor drive of the traction system. In addition, the conventional H-bridge circuit suffers from ripple power pulsating at second-order line frequency, and a scheme of active ripple compensation circuit has been explored to solve this second-order ripple problem, in which a pair of power switches shared traction mode, a ripple energy storage capacitor, and an energy transfer inductor. Simulation results in MATLAB/Simulink validated the eligibility of the proposed topology. The integrated charger can work as a 70 kW motor drive circuit or a converter with an active ripple compensation circuit for 3 kW charging the battery. The impact of the proposed topology and control strategy on the integrated charger power losses, efficiency, power density, and thermal performance has also been analysed and simulated.
Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein‐rich matrices for topical applications (2013)

The technology of combining and stably concentrating phytoactive polyphenols with proteins has potential use for cosmetic topical applications.
Antiviral activity of monoterpenes beta-pinene and limonene against herpes simplex virus in vitro. (2014)

These results suggest that monoterpenes in essential oils exhibit antiherpetic activity in the early phase of viral multiplication and might be used as potential antiviral agents.
Increased endothelial albumin permeability mediated by protein kinase C activation. (1990)

We examined the effects of activation of endothelial protein kinase C (PKC) of the endothelial barrier function. Exposure of confluent bovine pulmonary artery endothelial cell monolayers to phorbol 12-myristate 13-acetate (PMA) resulted in concentration-dependent (10(-8)-10(-6) M) increases in PKC activity and in the transendothelial flux of 125I-albumin. Exposure of the endothelium to 1-oleoyl 2-acetyl glycerol (OAG) also increased the transendothelial flux of 125I-albumin in a concentration-dependent manner. Neither 4 alpha-phorbol didecanoate nor 1-mono-oleoyl glycerol, which do not activate PKC, altered permeability. The increase in 125I-albumin permeability induced by PMA was inhibited by 25 microM H7 (a PKC inhibitor), but not by the control compound HA1004 (25 microM). After 16 h of exposure to PMA, 125I-albumin permeability returned to baseline and a significant reduction in cytosolic PKC activity was noted. Further challenge with PMA at this time resulted in no significant increase in PKC activity indicating downregulation of the enzyme; moreover, this PMA challenge did not increase endothelial permeability. Exposure of endothelial monolayers to phospholipase C (PLC), which increases membrane phosphatidylinositide turnover, or to alpha-thrombin also induced concentration-dependent activation of PKC and increases in 125I-albumin endothelial permeability. The thrombin- and PLC-induced permeability increases were inhibited by H7, but not by HA1004. The activation of endothelial PKC directly by PMA or OAG and by PLC and alpha-thrombin increases the transendothelial albumin permeability, indicating that PKC activation is an important signal transduction pathway by which extracellular mediators increase endothelial macromolecular transport.
Transcriptional analysis of the white spot syndrome virus major virion protein genes (2003)

White spot syndrome virus (WSSV) is a member of a new virus family (Nimaviridae) infecting crustaceans. The regulation of transcription of WSSV genes is largely unknown. Transcription of the major WSSV structural virion protein genes, vp28, vp26, vp24, vp19 and vp15, was studied to search for common promoter motifs for coordinate expression. The temporal expression of these genes and both 5' and 3' ends of the mRNA were determined, using infected crayfish gill tissue as a RNA source. RT-PCR showed that all five genes are expressed late in infection compared to the early ribonucleotide reductase large subunit gene. 5' RACE studies revealed a consensus late transcription initiation motif for only two of the five major virion protein genes. This motif was only found in one other upstream region of the putative translational start site of a gene with unknown function (ORF 158). No other conserved sequence motifs could be detected in the sequences surrounding the transcriptional start sites of the five major virion protein genes. All 5' ends were located about 25 nt downstream of an A/T rich sequence, including the consensus TATA-box sequence for vp15. The absence of a consensus motif is distinct from gene regulation of other large dsDNA viruses and suggests a unique regulation of WSSV transcription, in line with its unique taxonomic position.
Functionalisation of textiles by inorganic sol–gel coatings (2005)

The maintenance and improvement of current properties and the creation of new material properties are the most important reasons for the functionalisation of textiles. The coating of textiles with chemically or physically modified silica sols with particle diameters smaller than 50 nm (“nanosols”) enables the manifold alteration of their physico-mechanical, optical, electrical and biological properties. Thus the protection of textiles against destruction and the creation of new advantageous functions can be realised. Prospective new products to be developed include textiles with water, oil and soil repellency and with antimicrobial properties. This article discusses recent results from applying modified silica nanosols to the functionalisation of textiles.
Molecular Signals in Plant-Microbe Communications (1991)

Regulation of Gene Expression and Signals in Fungal Development (Ralph A. Dean). Analysis of Transcription Control Sequences of Fungal Genes (Peter J. Punt and Cees A.M.J.J. van den Hondel). Gene Expression in Susceptibility and Resistance of Fungal Plant Diseases (Hachiro Oku). Plant-Fungal Communications that Trigger Genes for Breakdown and Reinforcement of Host Defensive Barriers (P.E. Kolattukudy). Nonhost Resistance in Plant-Fungal Interactions (Lee A. Hadwiger). A Model System for the Study of Plant-Fungal Interactions: Tomato Leaf Mold Caused by Cladosporium fulvum (Richard P. Oliver). Opines in Agrobacterium Biology (Yves Dessaux, Annik Petit, and Jacques Tempe). Chemical Signaling Between Agrobacterium and Its Plant Host (Stanton B. Gelvin). Agrobacterium - Plant Cell Interaction: Induction of Vir Genes and T-DNA Transfer (Vitaly Citovsky, B. Gail McLean, Elizabeth Greene, Elizabeth Howard, Gretchen Kuldau, Yvonne Thorstenson, John Zupan, and Patricia Zambryski). Chromosomal- and TI Plasmid-Mediated Regulation of Agrobacterium Virulence Genes: Molecular Intercommunication (Clarence I. Kado). Phytohormones and Olive Knot Disease (Giuseppe Surico and Nicola S. Iacobellis). Iron: A Modulator in Bacterial Virulence and Symbiotic Nitrogen-Fixation (Dominique Expert and Paul R. Gill, Jr.). Bacterial Phytotoxin Syringomycin and Its Interaction with Host Membranes (Jon Y. Takemoto). Bacterially Delivered Toxins for Studying Plant Metabolism (Thomas J. Knight and Pat J. Langston-Unkefer). Attachment, Lectin, and Initiation of Infection in (Brady) Rhizobium-Legume Interactions (Jan W. Kijne, Ben J.J. Lugtenberg, and Gerrit Smit). Rhizobium Nodulation Signals (Jean Denarie and Philippe Roche). Regulation of Nodulation Genes in Rhizobia (Adam Kondorosi). Rhizobial Polysaccharides Required in Symbioses with Legumes (K. Dale Noel). The Role of the Rhizobium Cell Surface During Symbiosis (James X. Gray, Ruud A. de Maagd, Barry G. Rolfe, Andrew W.B. Johnston, and Ben J.J. Lugtenberg). Rhizopines in the Legume-Rhizobium Symbiosis (Peter J. Murphy and Christopher P. Saint). Arabidopsis thaliana as a Model Host for Studying Plant-Pathogen Interactions (Keith R. Davis). Hydroxyproline-Rich Glycoproteins in Plant-Microbe Interactions and Development (Keith L. Wycoff, Richard A. Dixon, and Christopher J. Lamb). Molecular Determinants of Plant-Virus Interaction (Steve Daubert). Plants and Endomycorrhizal Fungi: The Cellular and Molecular Basis of Their Interaction (Paola Bonfante-Fasolo and Silvia Perotto). A Search for Signals in Endophytic Micro-Organisms (Anton Quispel). Signals and Regulation in the Development of Striga and Other Parasitic Angiosperms (James L. Riopel and Michael P. Timko).