gebhart/patrepeval huggingface dataset:
The role of CRMP4 in nerve regenerations (2007)

The inability of CNS neurons to regenerate and reform functional connections following spinal cord injury has devastating clinical consequences. The failure of CNS neurons to spontaneously regenerate following injury can be partially attributed to the expression of neurite outgrowth inhibitory myelin associated inhibitors (MAIs). MAIs signal through a tripartite receptor complex to activate the cytosolic protein RhoA and influence cytoskeletal dynamics. RhoA antagonists promote neuronal survival and regeneration in animal models of nerve injury. However, RhoA's potential as a therapeutic target may be limited by its widespread roles in multiples cellular processes and cell types. In an attempt to discover more specific therapeutic targets to promote nerve regeneration, our lab identified the cytosolic phosphoprotein CRMP4b (Collapsin Response Mediator Protein 4b) as a protein that functionally interacts with RhoA to mediate neurite outgrowth inhibition. siRNA-mediated knockdown of CRMP4 and blockade of the RhoA-CRMP4b interaction with a competitive peptide (C4RIP) attenuates myelin-dependent neurite outgrowth inhibition. Analysis of the proximal tip of extending axons (growth cones) by time lapse video microscopy reveals that C4RIP regulates filopodial dynamics indicating that C4RIP modulates the actin cytoskeleton. We are currently investigating the in vivo roles of CRMP4 in regeneration in an optic nerve injury model by developing readily deliverable C4RIP and a CRMP4 knockout mouse. Elucidating the role of CRMP4 in nerve regeneration may provide insight into the molecular mechanisms following nervous system injury.
Multilayer and Multimodal Fusion of Deep Neural Networks for Video Classification (2016)

This paper presents a novel framework to combine multiple layers and modalities of deep neural networks for video classification. We first propose a multilayer strategy to simultaneously capture a variety of levels of abstraction and invariance in a network, where the convolutional and fully connected layers are effectively represented by our proposed feature aggregation methods. We further introduce a multimodal scheme that includes four highly complementary modalities to extract diverse static and dynamic cues at multiple temporal scales. In particular, for modeling the long-term temporal information, we propose a new structure, FC-RNN, to effectively transform pre-trained fully connected layers into recurrent layers. A robust boosting model is then introduced to optimize the fusion of multiple layers and modalities in a unified way. In the extensive experiments, we achieve state-of-the-art results on two public benchmark datasets: UCF101 and HMDB51.
Network of Dividing Wall Columns in Complex Process Units (2018)

The majority of dividing wall column (DWC) applications in the refining industry consists of stand-alone columns, whether a retrofit or a grassroots column. Functional DWCs, first commercialized in the 1980s, are encountered in naphtha splitters or reformate splitters. Agrawal, 2001 and Asprion et al., 2011 talk about DWC columns for multicomponent separations. Additionally, Yildirim et al., 2011 reviews several DWCs implementations in the industry. In spite of successful stand-alone column implementation, this technology has not been applied on a larger industrial scale to complex refinery units consisting of a network of columns. This paper discusses the application of DWC technology to naphtha hydrotreating (NHT) and isomerization (ISOM) units (Kalita et al., 2018). Most of the columns in these units often operate at high pressures and temperatures that result in a costly and energy-intensive operation. A comparison between conventional NHT/ISOM schemes and DWC integrated NHT/ISOM schemes is presented. The DWC integrated configuration presented is a licensed grassroots unit for a Middle East refinery. With the demand for such units ramping up in the refining industry, DWCs can revolutionize these process schemes. The benefits of combining the operation of two (or more) columns in such units to create a network of DWCs include lower capital cost due to the lesser number of equipment required. Additionally, DWCs have been shown to lower energy consumption of units by about 20-30% as compared to conventional columns (Dejanovic et al., 2010 and Kiss, 2009). Hence, integrating DWC technology in conventional NHT and ISOM units has the potential to lower the carbon footprint of these units while improving their efficiency and profitability as well.
Assessment of Vitamin B12 Absorption Based on the Accumulation of Orally Administered Cyanocobalamin on Transcobalamin (2009)

Our data demonstrate that CNCbl is absorbed unchanged and accumulates on circulating TC. We suggest that measuring TC-CNCbl will improve the assessment of vitamin B(12) absorption.
Cell type‐dependent recruitment of trichostatin A‐sensitive repression of the human 5‐HT1A receptor gene (2004)

Regulation of serotonin (5-HT)1A receptor expression in brain is implicated in mood disorders such as depression and anxiety. Transcriptional activity of the human 5-HT1A receptor gene was strongly repressed by a negative regulatory region containing a consensus repressor element-1 (RE-1) and two copies of the dual repressor element (DRE) identified in the rat 5-HT1A receptor gene. REST/NRSF, a silencer of neuronal genes, bound the 5-HT1A RE-1 and repressed the 5-HT1A promoter. Inactivation of RE-1 completely abolished REST-mediated repression, but resulted in only partial (15-50%) de-repression of basal 5-HT1A promoter activity. The human 5-HT1A DRE sequences bound specifically to the novel repressor Freud-1 (5'repressor element under dual repression binding protein-1) and conferred repressor activity at 5-HT1A or SV40 promoters. In 5-HT1A-negative cells [L6, human embryonic kidney (HEK) 293], the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) abolished repression mediated by both RE-1/REST and DRE/Freud-1, and induced almost complete de-repression of the 5-HT1A gene. By contrast, in 5-HT1A-expressing neuronal cells (RN46A, SN-48) TSA blocked RE-1/REST repression, but did not affect DRE/Freud-1-mediated repression. Thus in contrast to REST, Freud-1 mediates HDAC-independent repression of the 5-HT1A receptor promoter in neuronal 5-HT1A-positive cells, suggesting that HDAC recruitment might influence neuron-specific gene expression by further silencing expression in non-neuronal tissue.
Analytics-Modulated coding of surveillance video (2010)

Video surveillance systems increasingly use H.264 coding to achieve 24×7 recording and streaming. However, with the proliferation of security cameras, and the need to store several months of video, bandwidth and storage costs can be significant. We propose a new compression technique to significantly improve the coding efficiency of H.264 for surveillance video. Video content is analyzed and video semantics are extracted using video analytics algorithms such as segmentation, classification and tracking. In contrast to existing approaches, our Analytics-Modulated Compression (AMC) scheme does not require coding of object shape information and produces bit-streams that are standards-compliant and not limited to specific H.264 profiles. Extensive experiments were conducted involving real surveillance scenes. Results show that our technique achieves compression gains of 67% over JM. We also introduced AMC Rate Control (AMC RC) which allocates bits in response to scene dynamics. AMC RC is shown to significantly reduce artifacts in constant-bitrate video at low bitrates.
Hydrogen by thermochemical reactions (1978)

The production of hydrogen by thermochemical reactions is briefly reviewed. Specific cycles discussed are: S/S, I/S, Br/S, Fe/Fe. The first element represents the one which is oxidized in the hydrogen evolution reaction, the second that which is reduced in the oxygen evolution reaction. The use of solar energy as the primary energy source to decompose water is considered. (LK)
Acoustic fiber sensor arrays (2004)

The acoustic fiber sensor arrays that have been developed over the past two decades for oil exploration and other applications can support hundreds of fiber hydrophones per fiber pair and exhibit exceptional properties, including shot-noise-limited sensitivities better than 1 μrad/√Hz, high stability, and dynamic ranges well in excess of 130 dB. This article reviews the main configurations reported to date, which are based on ladder architectures utilizing either Mach-Zehnder or Sagnac interferometric sensors and time-domain multiplexing. The emphasis is placed on their principles, performance characteristics, and relative advantages regarding such key issues as signal fading, polarization-induced fading, frequency response, sensitivity, and the number of sensors that can be multiplexed on a given pair of fibers.
Antibody Detection of Venom Protein Variation within a Population of the Rattlesnake Crotalus v. viridis (1992)

Michael Anaya, Eppie D. Rael, Carl S. Lieb, John C. Perez, Richard J. Salo, Antibody Detection of Venom Protein Variation within a Population of the Rattlesnake Crotalus v. viridis, Journal of Herpetology, Vol. 26, No. 4 (Dec., 1992), pp. 473-482
Botulinum toxin detection using AlGaN∕GaN high electron mobility transistors (2008)

Antibody-functionalized, Au-gated AlGaN∕GaN high electron mobility transistors (HEMTs) were used to detect botulinum toxin. The antibody was anchored to the gate area through immobilized thioglycolic acid. The AlGaN∕GaN HEMT drain-source current showed a rapid response of less than 5s when the target toxin in a buffer was added to the antibody-immobilized surface. We could detect a range of concentrations from 1to10ng∕ml. These results clearly demonstrate the promise of field-deployable electronic biological sensors based on AlGaN∕GaN HEMTs for botulinum toxin detection.
Synchronization algorithms for wireless data transmission using orthogonal frequency division multiplexing (ofdm) (1997)

Orthogonal frequency division multiplexing (OFDM) is a multicarrier modulation method which provides efficient bandwidth utilization and robustness against multipath delay spread. In an OFDM system, finding the symbol timing, the carrier frequency offset, and the sampling rate offset at the receiver is important in the recovery of the signal. Synchronization methods are needed which will work well for signals passing through frequency selective channels with large delay spreads. This thesis presents methods to acquire synchronization for either a continuous stream of data as in a broadcast application or for a burst of data as in a wireless local area network. The ratio of the number of overhead bits for synchronization to the number of message bits must be kept to a minimum, and low-complexity algorithms and rapid acquisition are needed. The carrier frequency offset can be many subcarrier spacings, so a large carrier frequency acquisition range is necessary.
A general method using two training symbols is presented and analyzed. First the symbol/frame timing is found by searching for a symbol in which the first half is identical to the second half in the time domain. Then the carrier frequency offset is partially corrected, and a correlation with a second symbol is performed to find the carrier frequency offset. This carrier frequency offset estimate is shown to approach the Cramer-Rao lower bound for variance. The symbol timing estimate can be refined after the frequency correction by using matched filtering in the time domain to determine the channel impulse response. Simulations are presented over three types of channels to compare several symbol timing estimators. The maximum likelihood estimator for the sampling rate offset is presented. This can be used if there will be a large enough offset to cause a degradation in the received signal. Another contribution is a synchronization method requiring no training data. This could be useful for systems with simple constellations such as QPSK.
Synthesis of Silicon Nitride Powder from Silica Reduction (1982)

Silicon nitride powder synthesis was investigated via the silica reduction method. Adding Si 3 N 4 to the SiO 2 ‐C mixture increased the reaction rate and promoted the formation of homogeneous Si 3 N 4 grains. This effect could be explained on the basis that each Si 3 N 4 particle acts as a ‘seed’ for the reaction.
A New Design Approach to Mitigating the Effect of Parasitics in Capacitive Wireless Power Transfer Systems for Electric Vehicle Charging (2019)

This paper introduces a new design approach to mitigate the effect of parasitic capacitances and achieve high performance in large air-gap capacitive wireless power transfer (WPT) systems for electric vehicle (EV) charging. In a capacitive WPT system for EVs, the vehicle chassis and roadway introduce multiple parasitic capacitances that can overwhelm the coupling capacitance and severely degrade power transfer and efficiency. The proposed approach addresses this challenge by employing split-inductor matching networks, which allow the complex network of parasitic capacitances to be simplified into an equivalent four-capacitance model. The shunt capacitances of this model are directly utilized as the matching network capacitors, hence, absorbing the parasitic capacitances and eliminating the need for discrete high-voltage capacitors. A systematic procedure is developed to accurately measure the equivalent capacitances of the model, enabling the system's performance to be reliably predicted. The proposed approach is used to design two 6.78-MHz 12-cm air-gap prototype capacitive WPT systems with capacitor-free matching networks. The first system transfers up to 590 W using 150-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> square coupling plates and achieves an efficiency of 88.4%. The second prototype system transfers up to 1217 W using 118-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> circular coupling plates, achieving a power transfer density of 51.6 kW/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The measured output power profiles of the two systems match well with their predicted counterparts, validating the proposed design approach.
PixelTone (2013)

Photo editing can be a challenging task, and it becomes even more difficult on the small, portable screens of mobile devices that are now frequently used to capture and edit images. To address this problem we present PixelTone, a multimodal photo editing interface that combines speech and direct manipulation. In this video, we demonstrate how our system uses natural language for expressing users' desired changes to an image. We also demonstrate how we combine natural language and touch gestures for creating named references and sketching to localize image operations to specific regions.
Antibodies Reactive with the N-Terminal Domain of<i>Plasmodium falciparum</i>Serine Repeat Antigen Inhibit Cell Proliferation by Agglutinating Merozoites and Schizonts (1999)

The serine repeat antigen (SERA) is a vaccine candidate antigen of Plasmodium falciparum. Immunization of mice with Escherichia coli-produced recombinant protein of the SERA N-terminal domain (SE47') induced an antiserum that was inhibitory to parasite growth in vitro. Affinity-purified mouse antibodies specific to the recombinant protein inhibited parasite growth between the schizont and ring stages but not between the ring and schizont stages. When Percoll-purified schizonts were cultured with the affinity-purified SE47'-specific antibodies, schizonts and merozoites were agglutinated. Indirect-immunofluorescence assays with unfixed parasite cells showed that SE47'-specific immunoglobulin G (IgG) bound to SERA molecules on rupturing schizonts and merozoites but the IgG did not react with the schizont-infected erythrocytes (RBC). Furthermore, double-fluorescence staining against SE47'-specific IgG and anti-human RBC membrane IgG showed that the RBC membrane disappeared from SE47'-specific-IgG-bound schizonts after cultivation. These observations suggest that the SE47'-specific antibodies inhibit parasite growth by cross-linking SERA molecules that are associated with merozoites in rupturing schizonts with partly broken RBC and parasitophorous vacuole membranes, blocking merozoite release.
Real-time Sound Source Separation: Azimuth Discrimination and Resynthesis (2004)

Part of the Other Engineering Commons This Conference Paper is brought to you for free and open access by the Audio Research Group at
Binary eutectics formed between ammonium nitrate and amine salts of 5-nitrotetrazole I. preparation and initial characterization (1983)

Abstract We have found that both the ammonium salt of 5-nitrotetrazole (ANT) and the ethylenediamine salt of 5-nitrotetrazole (ENT) form eutectics with ammonium nitrate (AN). Initial characterization and small-scale sensitivity tests of CO2-balanced AN/ANT and AN/ENT formulations were performed; it was found that both eutectics were less sensitive in all tests than pure ANT or ENT, respectively. The phase diagrams of both mixtures were also determined. ANT forms a eutectic with AN that melts at 121°C; the eutectic composition of the AN/ANT system is 78.5 mol% AN. The eutectic temperature and composition of the AN/ENT system were found to be 110.5°C and 87.8 mol% AN, respectively. Thermal stability studies of the eutectics indicate that they are stable below 160°C and that thermal decomposition occurs slowly over a long period of time. The detonation velocities of both eutectics, measured unconfined at 2.54-cm diameter, were found to be within 95% of those predicted by the Kamlet-Jacobs method assuming ideal behavior.
A Ga<sub>1-x</sub>Al<sub>x</sub>As monolithic opto-isolator (1980)

The performance of a Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</inf> Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> As monolithic opto-isolator incorporating identical emitter and detector structures is described. The device is fabricated from graded bandgap Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</inf> Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> As grown by liquid phase epitaxy on a semi-insulating GaAs substrate. Three identical rectangular diode elements are fashioned on the chip; the center element acts as an edge-emitting LED and the outer two bars serve as edge-receiving photodiodes. Air-isolated prototype structures possess optical coupling nearly comparable to typical hybrid devices, and this coupling will be improved by dielectric isolation. Isolation voltages between the LED and the detector exceed 1400 volts. The devices achieve excellent performance in both digital and analog signalling tests.
Native and Fc Enhanced Therapeutic Human Monoclonal Antibodies Targeting the Intracellular WT1 Oncogene Product in Leukemia. (2012)

Abstract Abstract 2599 The Wilms' tumor oncogene protein (WT1) is an intracellular, oncogenic transcription factor that is over-expressed in leukemias and a wide range of cancers. WT1 may be expressed in leukemia stem cells. RMFPNAPYL, “RMF”, a WT1-derived CD8 T cell epitope presented by HLA-A0201, is a validated target for T cell-based immunotherapy, used in multiple clinical trials of vaccines and cellular therapies. Therefore, we hypothesized that a “TCR-like antibody” specific for the WT1 peptide/HLA-A0201 complex might be an effective therapeutic agent. Using phage display technology, we generated 2 lead, high avidity (Kd < 0.2nM), fully human monoclonal antibodies (mAb) specific for the WT1 RMF peptide/HLA-A0201 complex. One version, ESK1, is a native human IgG1. A second version, ESKM, with enhanced antibody dependent human effector cell cytotoxicity (ADCC) function due to altered Fc glycolsylation was also prepared. ESK mAb bind to leukemia lines and other cancer cell lines, as well as primary leukemia cells that are both WT1+ and HLA-A0201+. In vitro, both ESK mAb mediated ADCC against CML cells, at concentrations below 3 ug/ml, but ESKM was about 8–10 fold more potent and could kill targets with far fewer peptide/MHC complexes expressed on the cell surface. At therapeutic doses of ESKM, there was no difference in biodistribution between the 2 mAb in C57BL6 mice or in mice that were transgenic for HLA-A0201. Low doses of ESK (25–100ug twice) effectively treated an established disseminated, ALL or human bcr/abl + lymphoid leukemias in a NSG mouse model (T, B and NK deficient) and prolonged survival. In mice, ESKM was slightly more effective than ESK1. An F(Ab')2 version of the antibody had no anti-tumor effect, indicating that an Fc-mediated mechanism plays the major role in therapy. When combined with a single infusion of human CD34-, CD3-, human NK and monocyte effectors in the NSG mice, therapeutic effects of the mAb were more pronounced and more durable. There was no therapeutic effect of either mAb on WT1 low/A0201 negative disseminated Daudi ALL in mice. There was no observed toxicity in HLA-A0201 transgenic mice at the therapeutic mAb dose and schedule. ESK mAb are potential therapeutic agents for ALL, CML, other leukemias and cancers over-expressing the WT1 oncoprotein. Its expression in early leukemia cells may allow for elimination of the progenitors. The data also provide proof of concept for developing therapeutic mAb targeting important intracellular oncogenic proteins. Disclosures: Yan: Eureka: Employment, Equity Ownership. Liu:Eureka: Employment, Equity Ownership.
A three wavelength infrared focal plane array detector element (1994)

We have demonstrated a novel three wavelength InGaAs focal plane array pixel element for detection at wavelengths from 0.9-2.6 μm, where each of three wavelength sensitive detectors are individually addressable. This device consists of successively smaller bandgap layers of In/sub x/Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> spl minus/x/As (x/spl ges/0.53), separated by compositionally graded layers of InAs/sub y/P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> spl minus/y/ to decrease defects induced by lattice mismatch strain with the InP substrate. The various layers were selectively removed so that p-n junctions with different wavelength response are formed. The three detectors have quantum efficiencies between 55 and 95% for front illumination and 15 and 60% for back illumination, and dark currents from 0.01 to 10 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
<title>Three-dimensional imaging, compression, and reconstruction of digital holograms</title> (2003)

We create digital holograms of real-world objects using a process called phase-shift digital holography. This system has been used as the basis for a three-dimensional object reconstruction and recognition technique. We present the results of applying lossless and lossy data compression to individual holographic frames. The lossy techniques are based on quantization and amplitude equalization. We also present a novel technique that uses only phase information of the digital hologram for the real-time optical reconstruction of three-dimensional objects.