gebhart/patrepeval huggingface dataset:
The Impact of Time-Shift TV on TV Viewership and Ad Consumption (2017)

We partner with a large telecommunications provider to study the impact of Time-Shift Television (TSTV) on TV and advertisement consumption. TSTV automatically records the programs broadcasted on TV and makes them available to users for 7 days. We investigate the outcomes of a randomized experiment ran by our industry partner in which subscribers were gifted a new set of entertainment channels. A random subset of households were gifted these channels with TSTV. Another random subset received the channels without TSTV. This design allows us to attribute any observed differences in the behavior of these two groups to TSTV. Using difference-in-differences, we find that, on average, receiving TSTV increased daily TV time, did not reduce live TV viewership, and increased viewership concentration. Finally, we find that receiving TSTV did not impact the probability of ad exit from the pre-existing channels, suggesting that households did not use TSTV to strategically avoid advertisements.
Acquired perforating dermatosis. Evidence for combined transepidermal elimination of both collagen and elastic fibers (1989)

• Patients with renal disease or diabetes mellitus often have an acquired perforating disease of the skin develop that is characterized by hyperkeratotic papules with transepidermal elimination of degenerated material, including collagen or elastic fibers. There is disagreement regarding the most appropriate name for this disease. The pathologic process has been identified by various authors as reactive perforating collagenosis, elastosis perforans serpiginosa, perforating folliculitis, or Kyrle's disease. We have seen four patients with renal disease and/or diabetes whose skin biopsy specimens demonstrated combined transepidermal elimination of both collagen and elastic fibers. This finding is not characteristically seen in any of the previously defined perforating diseases. Since the histologic findings vary greatly in different lesions from different patients with renal disease, we recommend referring to this process as "acquired perforating dermatosis." It is best not to create a new category of perforating disease or to say that a given patient has one of the other four diseases based on random sampling of only a few lesions. (<i>Arch Dermatol.</i>1989;125:1074-1078)
Reaction of Pentafluoropropionic Anhydride Vapor on Polypeptide as Revealed by Mass Spectrometry. A Carboxypeptidase Mimetic Degradation (1992)

Abstract Pentafluoropropionic anhydride vapor at −18 °C degraded a dodecapeptide, AlaArgGlyIleLysGlyIleArgGlyPheSerGly to the peptides which are successively lacking from the C-terminus. The mass spectrum of the reaction mixture for 10 minutes indicated each molecular ions from the intact peptide up to the N-terminal dipeptide clearly, together with two types of successively degraded molecular ions, minus 18 and minus 45 M/Z respectively.
Performance assessment of pulse wave imaging using conventional ultrasound in canine aortas ex vivo and normal human arteries in vivo (2015)

The propagation behavior of the arterial pulse wave may provide valuable diagnostic information for cardiovascular pathology. Pulse Wave Imaging (PWI) is a noninvasive, ultrasound imaging-based technique capable of mapping multiple wall motion waveforms along a short arterial segment over a single cardiac cycle, allowing for the regional pulse wave velocity (PWV) and propagation uniformity to be evaluated. The purpose of this study was to improve the clinical utility of PWI using a conventional ultrasound system. The tradeoff between PWI spatial and temporal resolution was evaluated using an <i>ex vivo</i> canine aorta (n = 2) setup to assess the effects of varying image acquisition and signal processing parameters on the measurement of the PWV and the pulse wave propagation uniformity r<sup>2</sup>. PWI was also performed on the carotid arteries and abdominal aortas of 10 healthy volunteers (24.8 ± 3.3 y.o.) to determine the waveform tracking feature that would yield the most precise PWV measurements and highest r<sup>2</sup> values <i>in vivo</i>. The <i>ex vivo</i> results indicated that the highest precision for measuring PWVs ~ 2.5 - 3.5 m/s was achieved using 24-48 scan lines within a 38 mm image plane width (i.e. 0.63 - 1.26 lines/mm). The <i>in vivo</i> results indicated that tracking the 50% upstroke of the waveform would consistently yield the most precise PWV measurements and minimize the error in the propagation uniformity measurement. Such findings may help establish the optimal image acquisition and signal processing parameters that may improve the reliability of PWI as a clinical measurement tool.
Comparative Assessment of the Antimicrobial Susceptibility of<i>Staphylococcus aureus</i>Isolates from Bovine Mastitis in Biofilm Versus Planktonic Culture (2006)

Mastitis is one of the most important diseases in dairy cattle of which Staphylococcus aureus is a major pathogen. Despite an apparently good antimicrobial susceptibility in vitro, the cure of diseased animals from this bacteriological infection is often disappointing, which results in cases of recurrent clinical- and chronic subclinical infections. It has been suggested that these recurrent and chronic Staphylococcus infections can be attributed to the growth of bacteria in biofilm. The objective of this study was to compare the susceptibility for antimicrobial agents of S. aureus isolates obtained from bovine mastitis growing under different conditions. These conditions include a conventional conventional microbroth dilution assay in which minimal inhibitory concentration values are determined, the MBEC assay which measures both the susceptibility in biofilm and the susceptibility of sequester cells released from the biofilm. A comparison of the susceptibility for antimicrobial agents of a number of representative S. aureus isolates grown in broth (representing in vitro growth conditions) or milk (representing in vivo growth conditions) is also made. The results indicate that S. aureus isolates obtained from bovine mastitis are highly resistant to antimicrobial agents when growing in biofilms.
A Pre-processor for Numerical Analysis of Cross-Laminated Timber Structures (2015)

The thesis focuses on the development of a software for numerical modelling of X-Lam structures. La tesi si concentra sullo sviluppo di un software per la modellazione numerica di strutture in X-Lam
POIS, a Low Cost Tilt and Position Sensor: Design and First Tests (2015)

An integrated sensor for the measurement and monitoring of position and inclination, characterized by low cost, small size and low weight, has been designed, realized and calibrated at the Geomatics Lab of the University of Calabria. The design of the prototype, devoted to the monitoring of landslides and structures, was aiming at realizing a fully automated monitoring instrument, able to send the data acquired periodically or upon request by a control center through a bidirectional transmission protocol. The sensor can be released with different accuracy and range of measurement, by choosing bubble vials with different characteristics. The instrument is provided with a computer, which can be programmed so as to independently perform the processing of the data collected by a single sensor or a by a sensor network, and to transmit, consequently, alert signals if the thresholds determined by the monitoring center are exceeded. The bidirectional transmission also allows the users to vary the set of the monitoring parameters (time of acquisition, duration of satellite acquisitions, thresholds for the observed data). In the paper, hardware and software of the sensor are described, along with the calibration, the results of laboratory tests and of the first in field acquisitions.
Molecular Events that Control the Protein C Anticoagulant Pathway (1993)

Despite its rather recent identification, the protein C activation system has afforded many investigators with unique opportunities to probe the molecular basis by which cofactors function. Thrombomodulin clearly exerts its specificity switch both by interacting directly with the fibrinogen binding site on thrombin (exosite 1) and by altering the conformation within the enzyme center. At least in the case of thrombomodulin, these conformational changes appear to overcome repulsive interactions between acidic residues in the substrate and the enzyme. To determine whether the models derived from attempts at the molecular analysis of the protein C activation complex are at all relevant to the other coagulation complexes will require further examination, but the concept that residues near the cleavage site contact residues in the free enzyme in an unfavorable fashion, and that the cofactors overcome these inhibitory interactions is a hypothesis that is directly testable for all of the complexes. The availability of crystal structures for the coagulation enzymes, coupled with the capacity to mutagenize both the substrate and the enzyme, promises to provide new insights into molecular events that control coagulation.
Intensive intravenous methotrexate and mercaptopurine treatment of higher-risk non-T, non-B acute lymphocytic leukemia: A Pediatric Oncology Group study. (1994)

Combined data from this and our previous trial suggest that intensive MTX/MP may produce long-term disease-free survival in 70 to 75% of children with B-lineage ALL. In comparison to other intensive regimens, intensive MTX/MP is easy to administer, effective, and relatively nontoxic. If patients at risk for failure of MTX/MP can be identified prospectively, more aggressive regimens could be restricted to this smaller (25% to 30%) cohort.
Automated treatment planning for a dedicated multi‐source intracranial radiosurgery treatment unit using projected gradient and grassfire algorithms (2012)

PFX inverse planning can be performed using geometric isocenter selection and mathematical modeling and optimization techniques. The obtained treatment plans all meet or exceed clinical guidelines while displaying high conformity.
Multidirectional Hierarchical Nanocomposites Made by Carbon Nanotube Growth within Layer-by-Layer-Assembled Films (2011)

We demonstrate fabrication of multidirectional and hierarchical carbon nanotube (CNT) films on diverse substrates, using nanocomposite catalyst films prepared by layer-by-layer (LBL) assembly. CNT density and yield are controlled by the thickness of a montmorillonite clay/poly(dyallyldimethyl ammonium chloride (MTM/PDDA) support film. Using identical methods, few-walled CNTs are grown on flat silicon substrates, carbon fibers, and titanium wire mesh. On flat substrates, unique bilayer CNT forests, reminiscent of microscale “accordions”, form because of diffusion of the Fe catalyst through the support which is then split because of mechanical forces exerted by the growing CNTs. Electrochemical measurements of CNT-coated Ti wires demonstrate an 85-fold enhancement in specific capacitance, and 7.1 F/g for the CNTs alone. This novel approach to substrate engineering for CNT growth can create materials with unique and nonlinear properties by hierarchical ordering of CNTs at multiple length scales, and is scalable to large-area foils and fabrics.
Atypical Haemolytic Uraemic Syndrome Associated with a Hybrid Complement Gene (2006)

CFH mutation screening is recommended in all aHUS patients prior to renal transplantation because of the high risk of disease recurrence post-transplant in those known to have a CFH mutation. Because of our finding it will be necessary to implement additional screening strategies that will detect a hybrid CFH/CFHL1 gene.
Corneal Transduction to Inhibit Angiogenesis and Graft Failure (2003)

Corneas transduced with a lentivirus containing an endostatin::kringle-5 fusion gene demonstrated an inhibition of neovascularization and graft failure. E::K-5 gene transduction through a lentiviral vector system may be a useful adjunct to prevent graft neovascularization and corneal graft rejection in high-risk corneal transplants with antecedent rejection or neovascularization.
Meta-analysis of trials comparing anastrozole and tamoxifen for adjuvant treatment of postmenopausal women with early breast cancer (2008)

Anastrozole appears to have superior efficacy than tamoxifen in the adjuvant hormonal treatment of early breast cancer. Until further clinical evidence comes up, aromatase inhibitors should be the initial hormonal therapy in postmenopausal early breast cancer patients and switching should only be considered for patients who are currently receiving tamoxifen.
Large-Agglomerate-Size Lithium Manganese Oxide Spinel with High Rate Capability for Lithium-Ion Batteries (2000)

Lithium manganese oxide spinel (LiMn<sub>2</sub>O<sub>4</sub>) with a high rate capability was synthesized for rechargeable lithium-ion batteries. This material consisted of agglomerates (15 μm on an average) formed from smaller primary particles (ca. 0.5-3 μm). The rate performance of the spinel was examined in an electrochemical test cell where the spinel was the positive electrode and metallic lithium was the (negative) counter electrode. The specific power output of the cell was found to be more than 8000 W per kilogram of spinel during about 100 s at a discharge rate of 20 C, or more than 400 W per kilogram of spinel during about 1 h at a discharge rate of C/l.
Spinal Cord Injury Pain Classification: History, Current Trends, and Commentary (2007)

Pain following spinal cord injury (SCI) has been well described in the literature over the years, but both SCI pain research and clinical care have been hampered by the lack of a uniform method for assessing pain. There have been a large number of proposed classification systems published, but no consensus to date on what criteria are required for each subtype of pain or the procedures to be used to make that determination. Accordingly, the literature is filled with descriptions of clinical series and some controlled trials of the treatment of SCI pain with no clear idea as to what percentage of the sample experienced neuropathic pain, musculoskeletal pain, or both. The more recent literature has been more specific with trials directed at specific subtypes of SCI pain. In this article, we review the history of SCI classification schemes, describe current efforts to develop a unified classification scheme and an accompanying set of diagnostic procedures, and describe international efforts along these lines. We also describe translational work related to SCI pain and the benefits and shortcomings of current animal models of SCI pain. Finally, several of the authors provide comments on the direction they think the field needs to take to continue to move this line of inquiry further.
ChemInform Abstract: Palladium Nanoparticles on Graphite Oxide and Its Functionalized Graphene Derivatives as Highly Active Catalysts for the Suzuki—Miyaura Coupling Reaction. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Potential neuroleptic agents, N-((2-pyrrolidinyl)methyl)-2,3-dihydrobenzofuran-7-carboxamide derivatives. (1990)

A series of 2,3-dihydrobenzofuran-7-carboxamides, presenting a stabilized intramolecular hydrogen bond, was synthesized and evaluated in pharmacological models for antipsychotic activity. Among them, N-[(1-butyl-2-pyrrolidinyl)methyl]-2-methyl-5-sulfamoyl-2, 3-dihydrobenzofuran-7-carboxamide (15) showed an atypical neuroleptic profile similar to that of sulpiride (1) and more lipophilic properties than 1. Compound 15 was 11 times more potent in antagonistic activity on apomorphine-induced hyperactivity in mice (ED50 = 30 mg/kg, p.o.) and stronger in potentiation of methamphetamine lethality in rats than 1, while it was as weak in inhibitory activity of apomorphine-induced stereotype in rats (ED50 greater than 500 mg/kg, p.o.) as 1. On the other hand, N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methyl-5-methylthio-2, 3-dihydrobenzofuran-7-carboxamide (30) showed a classical neuroleptic profile with a potency comparable to haloperidol in antagonistic activity on apomorphine-induced hyperactivity in mice (ED50 = 0.65 mg/kg, p.o.). The structure-activity relationships were also discussed.
Algorithms for coherent diversity combining of M-ary orthogonal signals (1999)

This paper discusses the use of coherent demodulation for antenna array receivers employing direct sequence spread spectrum techniques and M-ary orthogonal modulation. Three different approaches are discussed. The first is a conventional receiver using training sequences and decision feedback for channel estimation. The other two techniques employ decisions from a simple noncoherent combining (O) receiver to circumvent the need for training sequences. The bit error ratio (BER) performance of coherent M-ary orthogonal modulation is derived. Some qualitative analysis is also presented for the algorithms, and simulation results are used to compare their performance in different scenarios.
In Vitro Study of Electroactive Tetraaniline-Containing Thermosensitive Hydrogels for Cardiac Tissue Engineering (2014)

Injectable hydrogels made of degradable biomaterials can function as both physical support and cell scaffold in preventing infarct expansion and promoting cardiac repair in myocardial infarction therapy. Here, we report in situ hydrogels consisting of thermosensitive PolyNIPAM-based copolymers and electroactive tetraaniline (TA). Studies showed that the addition of 2-methylene-1,3-dioxepane (MDO) provided the PolyNIPAM-based gel with biodegradability, and the introduction of tetraaniline endowed these copolymers with desirable electrical properties and antioxidant activities. The encapsulated H9c2 cells (rat cardiac myoblast) remained highly viable in the gel matrices. In vivo gel formation and histological analyses were performed in rats by subcutaneous injection and excellent biocompatibility was observed. Furthermore, the proliferation and intracellular calcium transients of H9c2 cells were also studied with (and without) electrical stimuli. Both in vitro and in vivo results demonstrated that electroactive hydrogel may be used as a promising injectable biomaterial for cardiac tissue engineering.
A portable time-domain LED fluorimeter for nanosecond fluorescence lifetime measurements (2014)

Fluorescence lifetime measurements are becoming increasingly important in chemical and biological research. Time-domain lifetime measurements offer fluorescence multiplexing and improved handling of interferers compared with the frequency-domain technique. In this paper, an all solid-state, filterless, and highly portable light-emitting-diode based time-domain fluorimeter (LED TDF) is reported for the measurement of nanosecond fluorescence lifetimes. LED based excitation provides more wavelengths options compared to laser diode based excitation, but the excitation is less effective due to the uncollimated beam, less optical power, and longer latency in state transition. Pulse triggering and pre-bias techniques were implemented in our LED TDF to improve the peak optical power to over 100 mW. The proposed pulsing circuit achieved an excitation light fall time of less than 2 ns. Electrical resetting technique realized a time-gated photo-detector to remove the interference of the excitation light with fluorescence. These techniques allow the LED fluorimeter to accurately measure the fluorescence lifetime of fluorescein down to concentration of 0.5 μM. In addition, all filters required in traditional instruments are eliminated for the non-attenuated excitation/emission light power. These achievements make the reported device attractive to biochemical laboratories seeking for highly portable lifetime detection devices for developing sensors based on fluorescence lifetime changes. The device was initially validated by measuring the lifetimes of three commercial fluorophores and comparing them with reported lifetime data. It was subsequently used to characterize a ZnSe quantum dot based DNA sensor.
Review Article: Quantum-based vacuum metrology at the National Institute of Standards and Technology (2018)

The measurement science in realizing and disseminating the unit for pressure in the International System of Units (SI), the pascal (Pa), has been the subject of much interest at NIST. Modern optical-based techniques for pascal metrology have been investigated, including multi-photon ionization and cavity ringdown spectroscopy. Work is ongoing to recast the pascal in terms of quantum properties and fundamental constants and in so doing, make vacuum metrology consistent with the global trend toward quantum-based metrology. NIST has ongoing projects that interrogate the index of refraction of a gas using an optical cavity for low vacuum, and count background particles in high vacuum to extreme high vacuum using trapped laser-cooled atoms.
Population pharmacokinetics–pharmacodynamics of alemtuzumab (Campath<sup>®</sup>) in patients with chronic lymphocytic leukaemia and its link to treatment response (2007)

Alemtuzumab displayed time- and concentration-dependent pharmacokinetics with large interpatient variability, both in pharmacokinetics and pharmacodynamics, which was probably reflective of differences in tumour burden among patients. A direct relationship between maximal trough concentrations and clinical outcomes was observed, with increasing alemtuzumab exposure resulting in a greater probability of positive tumour response.
Methodology for the preparation of N-guanidino-modified arginines and related derivatives (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethodology for the preparation of N-guanidino-modified arginines and related derivativesFrank L. Wagenaar and James F. Kerwin Jr.Cite this: J. Org. Chem. 1993, 58, 16, 4331–4338Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/jo00068a031https://doi.org/10.1021/jo00068a031research-articleACS PublicationsRequest reuse permissionsArticle Views711Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts