gebhart/patrepeval huggingface dataset:
A scalable pattern mining approach to web graph compression with communities (2008)

A link server is a system designed to support efficient implementations of graph computations on the web graph. In this work, we present a compression scheme for the web graph specifically designed to accommodate community queries and other random access algorithms on link servers. We use a frequent pattern mining approach to extract meaningful connectivity formations. Our Virtual Node Miner achieves graph compression without sacrificing random access by generating virtual nodes from frequent itemsets in vertex adjacency lists. The mining phase guarantees scalability by bounding the pattern mining complexity to O(E log E). We facilitate global mining, relaxing the requirement for the graph to be sorted by URL, enabling discovery for both inter-domain as well as intra-domain patterns. As a consequence, the approach allows incremental graph updates. Further, it not only facilitates but can also expedite graph computations such as PageRank and local random walks by implementing them directly on the compressed graph. We demonstrate the effectiveness of the proposed approach on several publicly available large web graph data sets. Experimental results indicate that the proposed algorithm achieves a 10- to 15-fold compression on most real word web graph data sets
Synthese von nichtsymmetrisch substituierten Perylen‐Fluoreszenzfarbstoffen (1991)

Synthesis of Nonsymmetrically Substituted Perylene Fluorescent Dyes A general method for the preparation of perylene‐3,4:9,10‐tetracarboxdiimides 1 with two different substituents at the nitrogen atoms is described: The easily prepared symmetrical tetracarboxdiimides 1 (R 1 =R 2 ) are transformed into carboxdiimide anhydrides 2 and condensed with primary amines to the corresponding tetracarboxdiimides 1 (R 1 ≢ R 2 ). Applications as fluorescent tracers in biochemistry and polymer chemistry are discussed.
Automating Skeletal Expansion: An Implant for Distraction Osteogenesis of the Mandible (2009)

BACKGROUND: Distraction osteogenesis (DO) is a technique of bone lengthening that makes use of the body's natural healing capacity. An osteotomy is created and a rigid distraction device is attached to the bone. After a latency period, the device is activated 2-4 times per day for a total of 1 mm/day of bone lengthening. This technique is used to correct a variety of congenital and acquired deformities of the mandible, midface and long bones. To shorten the treatment period and to eliminate the complications of patient activation of the device, an automated continuous distraction device would be desirable. It has been reported that continuous distraction generates adequate bone with lengthening at a rate of 2 mm/day, thereby reducing the treatment time. METHOD OF APPROACH: The device we describe here uses miniature high-pressure hydraulics, position feedback, and a digital controller to achieve closed-loop control of the distraction process. The implanted actuator can produce up to 40N of distraction force on linear trajectories as well as curved distraction paths. In the paper we detail the spring-powered hydraulic reservoir, controller, and user interface. RESULTS: Experiments to test the new device design were performed in a porcine cadaver head and in live pigs. In the cadaver head, the device performed an 11-day/11 mm distraction with a root-mean-squared position error of 0.09 mm. The device functioned for periods of several days in each of five live animals, though some component failures occurred, leading to design revisions. CONCLUSIONS: The test series showed that the novel design of this system provides the capabilities necessary to automate distraction of the mandible. Further developments will focus on making the implanted position sensor more robust and then carrying out clinical trials.
Cross-Modulation Interference for Pulse Position Modulated UWB Signals (2006)

The detection issues of UWB signals depend on the type of modulation scheme used during the transmission. The cross-modulation interference (CMI) for pulse position modulated (PPM) UWB signaling is introduced. The effects of CMI on the detection mechanism of selective-Rake (SRake), transmitted-reference (TR) and energy detector (ED) receivers are analyzed. The bit-error-rate (BER) performance of all three receivers in the presence and absence of CMI are studied through computer simulations. The results show that the CMI amount varies according to the modulation index and the performance degradation due to CMI can be extremely severe depending on the modulation index for all three receivers. The validity of the conventional optimal and orthogonal PPM criteria are checked considering the CMI effects. The results demonstrate that the conventional orthogonal PPM for all three receivers and the conventional optimal PPM criterion for N-SRake and TR receivers can be used in the presence of CMI. On the other hand, the BER performance of ED receivers using the conventional optimal PPM criterion result in error floor and this criterion is not valid to be used for ED receivers
A linearly polarized radial line slot antenna (1988)

A design for linearly polarized radial line slot antenna (RLSA) is proposed. A novel slot arrangement is presented which couples to the rotationally symmetric guided waves to produce a uniform aperture distribution with linear polarization. Basic characteristics were measured in the 12-GHz band on a model antenna. The radiation patterns indicate a reasonable cross-polarization level more than 15 dB below the copolarization. The poor VSWR response is typical for waveguide broadside arrays. A technique to suppress this reflection is to tilt the beam from the boresight.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Estimating unseen deduplication-from theory to practice (2016)

Estimating the deduplication ratio of a very large dataset is both extremely useful, but genuinely very hard to perform. In this work we present a new method for accurately estimating deduplication benefits that runs 3X to 15X faster than the state of the art to date. The level of improvement depends on the data itself and on the storage media that it resides on. The technique is based on breakthrough theoretical work by Valiant and Valiant from 2011, that give a provably accurate method for estimating various measures while seeing only a fraction of the data. However, for the use case of deduplication estimation, putting this theory into practice runs into significant obstacles. In this work, we find solutions and novel techniques to enable the use of this new and exciting approach. Our contributions include a novel approach for gauging the estimation accuracy, techniques to run it with low memory consumption, a method to evaluate the combined compression and deduplication ratio, and ways to perform the actual sampling in real storage systems in order to actually reap benefits from these algorithms. We evaluated our work on a number of real world datasets.
Low-loss single-mode terahertz waveguiding using Cytop (2006)

A polymer-based, Cytop planar photonic crystal waveguide (PPCW) was designed for guiding terahertz radiation. Results indicate that the propagation and coupling losses in the 0.2–1.1THz range are relatively small for a sheetlike thickness design. Spectral analysis of the transmission data reveals frequency selectivity of the PPCW. Calculations of the spatial distribution of the terahertz electric field through the waveguide show evidence of single-mode propagation at a 0.45THz central frequency. The highly transparent nature of Cytop from deep ultraviolet to the far infrared region indicates its potential use as an integral component in hybrid optics.
Staged concurrent program analysis (2010)

Concurrent program verification is challenging because it involves exploring a large number of possible thread interleavings together with complex sequential reasoning. As a result, concurrent program verifiers resort to bi-modal reasoning, which alternates between reasoning over intra-thread (sequential) semantics and inter-thread (concurrent) semantics. Such reasoning often involves repeated intra-thread reasoning for exploring each interleaving (inter-thread reasoning) and leads to inefficiency. In this paper, we present a new two-stage analysis which completely separates intra- and inter-thread reasoning. The first stage uses sequential program semantics to obtain a precise summary of each thread in terms of the global accesses made by the thread. The second stage performs inter-thread reasoning by composing these thread-modular summaries using the notion of sequential consistency. Assertion violations and other concurrency errors are then checked in this composition with the help of an off-the-shelf SMT solver. We have implemented our approach in the FUSION framework for checking concurrent C programs shows that avoiding redundant bi-modal reasoning makes the analysis more scalable.
Demonstration of Automatic, Simultaneous Compensation of PMD and Chromatic Dispersion in a 44×43Gbit/s Transmission over 6×100km High-PMD SMF (2002)

Automatic, simultaneous compensation of both PMD and chromatic dispersion in a 44times43 Gbit/s transmission experiment over 6times100 km high-PMD SMF is demonstrated for the first time. Longer-term experiments as well as WDM channel evaluations show effective compensation performance
Autophagy failure in <scp>A</scp>lzheimer's disease and the role of defective lysosomal acidification (2013)

Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates potentially toxic damaged organelles and protein aggregates. The important cytoprotective functions of autophagy are demonstrated by the diverse pathogenic consequences that may stem from autophagy dysregulation in a growing number of neurodegenerative disorders. In many of the diseases associated with autophagy anomalies, it is the final stage of autophagy-lysosomal degradation that is disrupted. In several disorders, including Alzheimer's disease (AD), defective lysosomal acidification contributes to this proteolytic failure. The complex regulation of lysosomal pH makes this process vulnerable to disruption by many factors, and reliable lysosomal pH measurements have become increasingly important in investigations of disease mechanisms. Although various reagents for pH quantification have been developed over several decades, they are not all equally well suited for measuring the pH of lysosomes. Here, we evaluate the most commonly used pH probes for sensitivity and localisation, and identify LysoSensor yellow/blue-dextran, among currently used probes, as having the optimal profile of properties for measuring lysosomal pH. In addition, we review evidence that lysosomal acidification is defective in AD and extend our original findings, of elevated lysosomal pH in presenilin 1 (PS1)-deficient blastocysts and neurons, to additional cell models of PS1 and PS1/2 deficiency, to fibroblasts from AD patients with PS1 mutations, and to neurons in the PS/APP mouse model of AD.
Ammonia Synthesis at Low Pressure (2017)

Ammonia can be synthesized at low pressure by the use of an ammonia selective absorbent. The process can be driven with wind energy, available locally in areas requiring ammonia for synthetic fertilizer. Such wind energy is often called "stranded," because it is only available far from population centers where it can be directly used. In the proposed low pressure process, nitrogen is made from air using pressure swing absorption, and hydrogen is produced by electrolysis of water. While these gases can react at approximately 400 °C in the presence of a promoted conventional catalyst, the conversion is often limited by the reverse reaction, which makes this reaction only feasible at high pressures. This limitation can be removed by absorption on an ammine-like calcium or magnesium chloride. Such alkaline metal halides can effectively remove ammonia, thus suppressing the equilibrium constraints of the reaction. In the proposed absorption-enhanced ammonia synthesis process, the rate of reaction may then be controlled not by the chemical kinetics nor the absorption rates, but by the rate of the recycle of unreacted gases. The results compare favorably with ammonia made from a conventional small scale Haber-Bosch process.
Synthesis of perfluoropolyethers via hydrocarbon polyesters: a new general method (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of perfluoropolyethers via hydrocarbon polyesters: a new general methodD. F. Persico, G. E. Gerhardt, and R. J. LagowCite this: J. Am. Chem. Soc. 1985, 107, 5, 1197–1201Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ja00291a019https://doi.org/10.1021/ja00291a019research-articleACS PublicationsRequest reuse permissionsArticle Views313Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<scp>l</scp>-(+)-Lactic acid production by co-fermentation of cellobiose and xylose without carbon catabolite repression using Enterococcus mundtii QU 25 (2014)

We established an effective high<sc>l</sc>-lactic acid production system based on fed-batch bacterial cultures utilising lignocellulosic biomass-derived mixed sugars without carbon catabolite repression.
Depositional Characteristics of Charged and Uncharged Droplets Applied by an Orchard Air Carrier Sprayer (1988)

ABSTRACT MASS-TRANSFER of fluorescent tracer onto front-sides and backsides of targets deployed throughout a large-scale grid was determined for comparison between charged and uncharged spray from air-atomizing electrostatic nozzles and uncharged spray from conventional hydraulic nozzles. Depending on target location, electrostatically charged spray achieved deposition increases ranging from 1.5 to 2.4-fold over uncharged droplets from the same air-atomizing induction-charging nozzles. The highest electrodeposition benefit was achieved on target backsides. Deposition of charged droplets did not surpass that achieved with 370 jum VMD (volume median diameter) droplets from conventional hydraulic orchard spraying nozzles. Suggested improvements to the electrostatic system included lowering the per-nozzle liquid flowrate to 160 mL/min to facilitate a 4-fold increase in droplet charging.
Transverse-flow gas lens (1991)

The concept of a transverse-flow gas lens is described. In this device, gas flows between two parallel plates that are heated or cooled so as to generate a parabolic variation of index of refraction in the region between the plates. A laser beam, propagating normal to the gas flow, can then be diverged, converged, or focused. A single module acts like a cylindrical lens. The use of two or three modules, arranged in an orthogonal manner, provides a spherical lens. Equations and tables are provided for the design of one-, two-, and three-module configurations. The advantages of the transverse-flow gas lens (relative to a device with a flow along the optic axis) are 1) thermal blooming is minimized (due to short residence time of fluid in laser beam); 2) the index of refraction profile is the same throughout each module, leading to good beam quality; and 3) the system is readily scaleable. However, a longer distance along the optical axis may be needed by the transverse-flow lens.
Properties of Acid Ureases from<i>Lactobacillus</i>and<i>Streptococcus</i>Strains (1990)

Journal Article Properties of Acid Ureases from Lactobacillus and Streptococcus Strains Get access Shigeya Kakimoto, Shigeya Kakimoto Microbiology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd., 17-85, Juso-honmachi 2-chome, Yodogawa-ku, Osaka 532, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideaki Miyashita, Hideaki Miyashita Microbiology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd., 17-85, Juso-honmachi 2-chome, Yodogawa-ku, Osaka 532, Japan Search for other works by this author on: Oxford Academic Google Scholar Yasuhiro Sumino, Yasuhiro Sumino Microbiology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd., 17-85, Juso-honmachi 2-chome, Yodogawa-ku, Osaka 532, Japan Search for other works by this author on: Oxford Academic Google Scholar Shun-ichi Akiyama Shun-ichi Akiyama Microbiology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd., 17-85, Juso-honmachi 2-chome, Yodogawa-ku, Osaka 532, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 54, Issue 2, 1 February 1990, Pages 381–386, https://doi.org/10.1080/00021369.1990.10869974 Published: 01 February 1990 Article history Received: 20 July 1989 Published: 01 February 1990
Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region (2019)

In the search for novel influenza inhibitors we evaluated 7-fluoro-substituted indoles as bioisosteric replacements for the 7-azaindole scaffold of Pimodivir, a PB2 (polymerase basic protein 2) inhibitor currently in clinical development. Specifically, a 5,7-difluoroindole derivative <b>11a</b> was identified as a potent and metabolically stable influenza inhibitor. <b>11a</b> demonstrated a favorable oral pharmacokinetic profile and in vivo efficacy in mice. In addition, it was found that <b>11a</b> was not at risk of metabolism via aldehyde oxidase, an advantage over previously described inhibitors of this class. The crystal structure of <b>11a</b> bound to influenza A PB2 cap region is disclosed here and deposited to the PDB.
A NEW INTRAVENOUS INFUSION SET FOR USE IN ANESTHESIA PRACTICE (1998)

S207 INTRODUCTION: Administration of intravenous (IV) fluids is an essential component of anesthesia practice. Most commonly used IV infusion systems are gravity driven macro-drip systems (i.e., 15 drops/ml), in which the flow rate is controlled by a roller clamp and monitored by observing the rate of drop formation in the dripping chamber. These IV systems are capable of delivering high flow rates (>100 ml/min) and are therefore suitable for volume replacement and rapid administration of medications. However, an inherent danger associated with these sets is over-administration of fluids. Typically, this occurs after the roller clamp is opened widely to compensate for increased flow impedance (e.g., BP cuff inflation/deflation, patient position). While the micro-drip sets (i.e., 60 drops/ml) allow for better control of flow rates, they do not readily allow for rapid fluid administration. Newer powered infusion pumps, allow for good control and higher infusion rates, but are more costly and/or labor intensive. METHODS: In an attempt to overcome these limitations of commonly used IV infusion systems, we constructed an IV infusion set (AnesFlow[copyright sign])* which combines the 60 drops/ml and 15 drops/ml drip chambers into a single unit (Figure 1). The IV spike(A) is inserted into an IV bag (not shown) and the flow rate through the 60 drops/ml chamber(B) is adjusted using a standard roller clamp(C). The macro-drip path(E) is not opened unless higher flow rates, or fluid and/or medication boluses are required. When required, the on/off clamp(D) in the macro-drip path is opened and the roller clamp(F) is adjusted to obtain the desired flow rate. When the higher infusion rates are no longer needed, slow infusion through the micro-path will spontaneously resume at the previously set rate as soon as the macro-drip is clamped off.Figure 1* Patent pending; U.S. Serial No. 08/823,064; "Intravenous Infusion System" RESULTS: (Figure 2)Figure 2: Flow characteristics of the dual drip chamber (AnesFlow[copyright sign])* infusion system.DISCUSSION Discussion The described infusion set conveniently and economically combines the strengths of the two most commonly used infusion sets, while avoiding their inherent limitations. Its use would be indicated in many clinical situations in which administration of IV fluids is undesirable or contraindicated, but where the ability to rapidly fluid resuscitate must be immediately available.
External ear canal electrode to be placed proximate the tympanic membrane (1988)

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Heterotetrameric Composition of Aquaporin-4 Water Channels (1999)

Aquaporin (AQP) water channel proteins are tetrameric assemblies of individually active approximately 30 kDa subunits. AQP4 is the predominant water channel protein in brain, but immunoblotting of native tissues has previously yielded multiple poorly resolved bands. AQP4 is known to encode two distinct mRNAs with different translation initiating methionines, M1 or M23. Using SDS-PAGE urea gels and immunoblotting with anti-peptide antibodies, four polypeptides were identified in brain and multiple other rat tissues with the following levels of expression: 32 kDa > 34 kDa > 36 kDa > 38 kDa. The 34 and 38 kDa polypeptides react with an antibody specific for the N-terminus of the M1 isoform, and 32 and 36 kDa correspond to the shorter M23 isoform. Immunogold electron microscopic studies with rat cerebellum cryosections demonstrated that the 34 kDa polypeptide colocalizes in perivascular astrocyte endfeet where the 32 kDa polypeptide is abundantly expressed. Velocity sedimentation, cross-linking, and immunoprecipitation analyses of detergent-solubilized rat brain revealed that the 32 and 34 kDa polypeptides reside within heterotetramers. Immunoprecipitation of AQP4 expressed in Xenopus laevis oocytes demonstrated that heterotetramer formation reflects the relative expression levels of the 32 and 34 kDa polypeptides; however, tetramers containing different compositions of the two polypeptides exhibit similar water permeabilities. These studies demonstrate that AQP4 heterotetramers are formed from two overlapping polypeptides and indicate that the 22-amino acid sequence at the N-terminus of the 34 kDa polypeptide does not influence water permeability but may contribute to membrane trafficking or assembly of arrays.