gebhart/patrepeval huggingface dataset:
Thermo-optical characterization of fluorescent rhodamine B based temperature-sensitive nanosensors using a CMOS MEMS micro-hotplate (2013)

A custom designed microelectromechanical systems (MEMS) micro-hotplate, capable of operating at high temperatures (up to 700 °C), was used to thermo-optically characterize fluorescent temperature-sensitive nanosensors. The nanosensors, 550 nm in diameter, are composed of temperature-sensitive rhodamine B (RhB) fluorophore which was conjugated to an inert silica sol-gel matrix. Temperature-sensitive nanosensors were dispersed and dried across the surface of the MEMS micro-hotplate, which was mounted in the slide holder of a fluorescence confocal microscope. Through electrical control of the MEMS micro-hotplate, temperature induced changes in fluorescence intensity of the nanosensors was measured over a wide temperature range. The fluorescence response of all nanosensors dispersed across the surface of the MEMS device was found to decrease in an exponential manner by 94%, when the temperature was increased from 25 °C to 145 °C. The fluorescence response of all dispersed nanosensors across the whole surface of the MEMS device and individual nanosensors, using line profile analysis, were not statistically different (<i>p</i> < 0.05). The MEMS device used for this study could prove to be a reliable, low cost, low power and high temperature micro-hotplate for the thermo-optical characterisation of sub-micron sized particles. The temperature-sensitive nanosensors could find potential application in the measurement of temperature in biological and micro-electrical systems.
Behavior of a Model Bipolar Cell with Cylindrical Electrodes (2023)

A type of bipolar cell, which consisted of graphite rods as bipolar electrodes, was constructed as a model of the packed bipolar cell. Behavior of this cell was investigated in the electro-deposition of copper from dilute solutions of copper ( II ) sulfate. The effective cathode area on each electrode was dependent on the applied voltage. The maximum energy efficiency was attained at a certain voltage. These results are discussed on the basis of the concept of threshold voltage and linear potential gradient in solution.
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation (2004)

Claspin is a homolog of Mrc1, a checkpoint protein required for the DNA replication checkpoint in yeast. In Xenopus , phosphorylated Claspin binds to xChk1 and regulates xChk1 activation in response to replication stress. In this study, we have shown that the human homolog of Claspin is required for resistance to multiple forms of genotoxic stress including UV, IR, and hydroxyurea. Phosphorylation of Claspin was found to depend on the ataxia telangiectasia mutated-Rad3 related (ATR) pathway. DNA damage induces the formation of a complex between Claspin and BRCA1, a second regulator of Chk1 activation. Claspin was found to control BRCA1 phosphorylation on serine 1524, a site whose phosphorylation is controlled by the ATR pathway. These results are consistent with a model in which ATR regulates Claspin phosphorylation in response to DNA damage and replication stress resulting in recruitment and phosphorylation of BRCA1. BRCA1 and Claspin then function to activate the tumor suppressor Chk1. Unexpectedly, we found that Claspin has a second, positive role in control of the cell cycle as Claspin overexpression increased cell proliferation. These results suggest that Claspin has properties of both a tumor suppressor and an oncogene.
Voltage Vector Analysis for Corona Location in Transformers (1971)

Location of corona or "partial discharges" in transformers can be an extremely difficult, costly and time-consuming process, especially if disassembly is required. The present state-of-the-art is such that a variety of sonic and electrical corona location techniques are employed, none of which is completely adequate, but with experience and patience, corona sources can be found.
A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design (2012)

We present the systematic prospective evaluation of a protein-based and a ligand-based virtual screening platform against a set of three G-protein-coupled receptors (GPCRs): the β-2 adrenoreceptor (ADRB2), the adenosine A(2A) receptor (AA2AR), and the sphingosine 1-phosphate receptor (S1PR1). Novel bioactive compounds were identified using a consensus scoring procedure combining ligand-based (frequent substructure ranking) and structure-based (Snooker) tools, and all 900 selected compounds were screened against all three receptors. A striking number of ligands showed affinity/activity for GPCRs other than the intended target, which could be partly attributed to the fuzziness and overlap of protein-based pharmacophore models. Surprisingly, the phosphodiesterase 5 (PDE5) inhibitor sildenafil was found to possess submicromolar affinity for AA2AR. Overall, this is one of the first published prospective chemogenomics studies that demonstrate the identification of novel cross-pharmacology between unrelated protein targets. The lessons learned from this study can be used to guide future virtual ligand design efforts.
Phase I/II Study of HSP90 Inhibitor AUY922 and Erlotinib for <i>EGFR</i>-Mutant Lung Cancer With Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (2015)

Partial responses were observed, but the duration of treatment with AUY922 and erlotinib was limited by toxicities, especially night blindness. This phase II study of AUY922 and erlotinib did not meet its primary end point.
Evaluation of Abbott BinaxNOW Rapid Antigen Test for SARS-CoV-2 Infection at Two Community-Based Testing Sites — Pima County, Arizona, November 3–17, 2020 (2021)

Rapid antigen tests, such as the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW), offer results more rapidly (approximately 15-30 minutes) and at a lower cost than do highly sensitive nucleic acid amplification tests (NAATs) (1). Rapid antigen tests have received Food and Drug Administration (FDA) Emergency Use Authorization (EUA) for use in symptomatic persons (2), but data are lacking on test performance in asymptomatic persons to inform expanded screening testing to rapidly identify and isolate infected persons (3). To evaluate the performance of the BinaxNOW rapid antigen test, it was used along with real-time reverse transcription-polymerase chain reaction (RT-PCR) testing to analyze 3,419 paired specimens collected from persons aged ≥10 years at two community testing sites in Pima County, Arizona, during November 3-17, 2020. Viral culture was performed on 274 of 303 residual real-time RT-PCR specimens with positive results by either test (29 were not available for culture). Compared with real-time RT-PCR testing, the BinaxNOW antigen test had a sensitivity of 64.2% for specimens from symptomatic persons and 35.8% for specimens from asymptomatic persons, with near 100% specificity in specimens from both groups. Virus was cultured from 96 of 274 (35.0%) specimens, including 85 (57.8%) of 147 with concordant antigen and real-time RT-PCR positive results, 11 (8.9%) of 124 with false-negative antigen test results, and none of three with false-positive antigen test results. Among specimens positive for viral culture, sensitivity was 92.6% for symptomatic and 78.6% for asymptomatic individuals. When the pretest probability for receiving positive test results for SARS-CoV-2 is elevated (e.g., in symptomatic persons or in persons with a known COVID-19 exposure), a negative antigen test result should be confirmed by NAAT (1). Despite a lower sensitivity to detect infection, rapid antigen tests can be an important tool for screening because of their quick turnaround time, lower costs and resource needs, high specificity, and high positive predictive value (PPV) in settings of high pretest probability. The faster turnaround time of the antigen test can help limit transmission by more rapidly identifying infectious persons for isolation, particularly when used as a component of serial testing strategies.
Structures of human nucleosomes containing major histone H3 variants (2011)

The nucleosome is the fundamental repeating unit of chromatin, via which genomic DNA is packaged into the nucleus in eukaryotes. In the nucleosome, two copies of each core histone, H2A, H2B, H3 and H4, form a histone octamer which wraps 146 base pairs of DNA around itself. All of the core histones except for histone H4 have nonallelic isoforms called histone variants. In humans, eight histone H3 variants, H3.1, H3.2, H3.3, H3T, H3.5, H3.X, H3.Y and CENP-A, have been reported to date. Previous studies have suggested that histone H3 variants possess distinct functions in the formation of specific chromosome regions and/or in the regulation of transcription and replication. H3.1, H3.2 and H3.3 are the most abundant H3 variants. Here, crystal structures of human nucleosomes containing either H3.2 or H3.3 have been solved. The structures were essentially the same as that of the H3.1 nucleosome. Since the amino-acid residues specific for H3.2 and H3.3 are located on the accessible surface of the H3/H4 tetramer, they may be potential interaction sites for H3.2- and H3.3-specific chaperones.
Intentions and attention in exploratory health search (2011)

We study information goals and patterns of attention in explorato-ry search for health information on the Web, reporting results of a large-scale log-based study. We examine search activity associated with the goal of diagnosing illness from symptoms versus more general information-seeking about health and illness. We decom-pose exploratory health search into evidence-based and hypothe-sis-directed information seeking. Evidence-based search centers on the pursuit of details and relevance of signs and symptoms. Hypothesis-directed search includes the pursuit of content on one or more illnesses, including risk factors, treatments, and therapies for illnesses, and on the discrimination among different diseases under the uncertainty that exists in advance of a confirmed diag-nosis. These different goals of exploratory health search are not independent, and transitions can occur between them within or across search sessions. We construct a classifier that identifies medically-related search sessions in log data. Given a set of search sessions flagged as health-related, we show how we can identify different intentions persisting as foci of attention within those sessions. Finally, we discuss how insights about foci dynamics can help us better understand exploratory health search behavior and better support health search on the Web.
A Magnetostatic Delay Line Oscillator (2005)

A single mode X-band oscillator has been built using a magnetostatic delay line as the frequency stabilization element. Experimental data are presented.
A 250-MHz Pipelined ADC-Based <inline-formula> <tex-math notation="LaTeX">$f_{S}/4$ </tex-math> </inline-formula> Noise-Shaping Bandpass ADC (2017)

A new f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S</sub> /4 bandpass ΔΣ-analog-to-digital converter (ADC) architecture is realized by feeding back the delayed quantization noise inherently produced by a pipelined ADC. Designed in a 55-nm global foundry (GF) LP-CMOS process, the prototype ADC sampling at 250 MHz achieves an Signal-to-Noise+Distortion Ratio of 72, 75.8, 80.1, and 85.3 dB in a 15.64-, 7.82-, 3.91-, and 1.953-MHz band, respectively, around a center frequency of 62.5 MHz with only first-order noise shaping, while consuming 103 mW of power, and achieving a maximum figure-of-merit of 158 dB.
Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons (2002)

Many behavioral effects of nicotine result from activation of nigrostriatal and mesolimbic dopaminergic systems. Nicotine regulates dopamine release not only by stimulation of nicotinic acetylcholine receptors (nAChRs) on dopamine cell bodies within the substantia nigra and ventral tegmental area (SN/VTA), but also on presynaptic nAChRs located on striatal terminals. The nAChR subtype(s) present on both cell bodies and terminals is still a matter of controversy. The purpose of this study was to use double-labeling in situ hybridization to identify nAChR subunit mRNAs expressed within dopamine neurons of the SN/VTA, by using a digoxigenin-labeled riboprobe for tyrosine hydroxylase as the dopamine cell marker and (35)S-labeled riboprobes for nAChR subunits. The results reveal a heterogeneous population of nAChR subunit mRNAs within midbrain dopamine neurons. Within the SN, almost all dopamine neurons express alpha2, alpha4, alpha5, alpha6, beta2, and beta3 nAChR mRNAs, with more than half also expressing alpha3 and alpha7 mRNAs. In contrast, less than 10% express beta4 mRNA. Within the VTA, a similar pattern of nAChR subunit mRNA expression is observed except that most subunits are expressed in a slightly lower percentage of dopamine neurons than in the SN. Within the SN, alpha4, beta2, alpha7, and beta4 mRNAs are also expressed in a significant number of nondopaminergic neurons, whereas within the VTA this only occurs for beta4. The heterogeneity in the expression of nAChR subunits within the SN/VTA may indicate the formation of a variety of different nAChR subtypes on cell bodies and terminals of the nigrostriatal and mesolimbic pathways.
Structure of Three-Way DNA Junctions. 2. Effects of Extra Bases and Mismatches (1994)

The structure of three-way DNA junctions, containing two linear double helices (arms) and a hairpin as a third arm, was studied by means of a cyclization technique. In addition to branched molecules containing perfect base-pairing in helical parts, three-way junctions with mismatches and extra non-complementary nucleotides (bulges) at junction points were studied. Molecules thus designed were ligated at identical conditions and their geometry was compared through the analysis of the efficiency of circle formation. The analysis showed that irregularities in base pairing listed above dramatically change the static and dynamic structural characteristics of the three-way junctions. All mismatches facilitate the kink between linear arms, but quantitatively, the effect depends on the position of the mismatch. The effect is maximal for GG-mismatch placed at the hairpin junction point. The results for bulges are of different kind, and they lead us to conclude that the three-way DNA junction with unpaired nucleotides adopts a T-like geometry with an angle around 90 degrees between arms containing the bulge and two other arms coaxially stacked. Broad distribution of circles indicates that this T-form geometry of bulge-containing junction is more flexible than initial pyramidal structure predominantly due to high mobility of the third arm.
The World Wide Telescope: An Archetype for Online Science (2004)

Most scientific data will never be directly examined by scientists; rather it will be put into online databases where it will be analyzed and summarized by computer programs. Scientists increasingly see their instruments through online scientific archives and analysis tools, rather than examining the raw data. Today this analysis is primarily driven by scientists asking queries, but scientific archives are becoming active databases that self-organize and recognize interesting and anomalous facts as data arrives. In some fields, data from many different archives can be cross-correlated to produce new insights. Astronomy presents an excellent example of these trends; and, federating Astronomy archives presents interesting challenges for computer scientists.
Walking, Cycling, and Swimming for Nonspecific Low Back Pain: A Systematic Review With Meta-analysis (2021)

Although less effective than alternate interventions, walking/running was slightly more effective than minimal/no intervention for treating chronic/recurrent LBP. <i>J Orthop Sports Phys Ther 2022;52(2):85-99. Epub 16 Nov 2021. doi:10.2519/jospt.2022.10612</i>.
Experimental Study of C-band EML based ONU Burst-mode Transmitter for 40 Gbit/s TWDM-PON (2015)

Using single 10Gbit/s EML with a wide operating temperature range, we achieved 40km transmission with a low dispersion penalty of less than 0.8dB over a wavelength range of 2.7nm covering 4-channel at 100GHz grid spacing.
The role of CD44 in HNSCC (2007)

Commentary to:Characterization of CD44v3 Containing Isoforms in Head and Neck CancerErika P. Reategui, Adriana Antúnez de Mayolo, Parpha M. Das, Frank C. Astor, Rakesh Singal, Kara L. Hamilton, W. Jarrard Goodwin, Kermit L. Carraway and Elizabeth J. FranzmannVolume: 5 | Issue: 9
Quantitative Design of Glassy Materials Using Temperature-Dependent Constraint Theory (2010)

The computational design of new materials has long been a “holy grail” within the materials chemistry community. However, accurate prediction of glass properties from first principles is often impossible, because of computational restrictions. Here, we present an alternative analytical modeling approach that focuses on the topology of the glass network. Specifically, we demonstrate the use of a temperature-dependent constraint model to enable accurate prediction of dynamic properties, taking the ternary soda−lime−borate glassy system as an example. Borate glasses have posed a particular challenge for traditional molecular dynamics simulations, because of the change in boron coordination that occurs in the presence of network modifiers. Focusing on topological constraints instead of interatomic force fields, the calculated compositional trends with our model are in quantitative agreement with experimental measurements. Our modeling approach enables the exploration of new composition spaces of glassy materials and is proving to be a valuable tool for revealing the topological source of properties such as liquid fragility, which has been a longstanding problem in condensed matter science.
Hybrid optoelectronic correlator architecture for shift-invariant target recognition (2013)

In this paper, we present theoretical details and the underlying architecture of a hybrid optoelectronic correlator (HOC) that correlates images using spatial light modulators (SLMs), detector arrays, and field programmable gate array (FPGA). The proposed architecture bypasses the need for nonlinear materials such as photorefractive polymer films by using detectors instead, and the phase information is yet conserved by the interference of plane waves with the images. However, the output of such an HOC has four terms: two convolution signals and two cross-correlation signals. By implementing a phase stabilization and scanning circuit, the convolution terms can be eliminated, so that the behavior of an HOC becomes essentially identical to that of a conventional holographic correlator (CHC). To achieve the ultimate speed of such a correlator, we also propose an integrated graphic processing unit, which would perform all the electrical processes in a parallel manner. The HOC architecture along with the phase stabilization technique would thus be as good as a CHC, capable of high-speed image recognition in a translation-invariant manner.
The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover (2002)

As in other adenine nucleotide binding cassette (ABC) proteins the nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator (CFTR) bind and hydrolyze ATP and in some manner regulate CFTR ion channel gating. Unlike some other ABC proteins, however, there are preliminary indications that the two domains of CFTR are nonequivalent in their nucleotide interactions (Szabo, K., Szakacs, G., Hegeds, T., and Sarkadi, B. (1999) J. Biol. Chem. 274, 12209-12212; Aleksandrov, L., Mengos, A., Chang, X., Aleksandrov, A., and Riordan, J. R. (2001) J. Biol. Chem. 276, 12918-12923). We have now characterized the interactions of the 8-azido-photoactive analogues of ATP, ADP, and 5'-adenyl-beta,gamma-imidodiphosphate (AMP-PNP) with the two domains of functional membrane-bound CFTR. The results show that the two domains appear to act independently in the binding and hydrolysis of 8-azido-ATP. At NBD1 binding does not require a divalent cation. This binding is followed by minimal Mg(2+)-dependent hydrolysis and retention of the hydrolysis product, 8-azido-ADP, but not as a vanadate stabilized post-hydrolysis transition state complex. In contrast, at NBD2, MgN(3)ATP is hydrolyzed as rapidly as it is bound and the nucleoside diphosphate hydrolysis product dissociates immediately. Confirming this characterization of NBD1 as a site of more stable nucleotide interaction and NBD2 as a site of fast turnover, the non-hydrolyzable N(3)AMP-PNP bound preferentially to NBD1. This demonstration of NBD2 as the rapid nucleotide turnover site is consistent with the strong effect on channel gating kinetics of inactivation of this domain by mutagenesis.
Efficient hybrid metrology for focus, CD, and overlay (2017)

In the advent of multiple patterning techniques in semiconductor industry, metrology has progressively become a burden. With multiple patterning techniques such as Litho-Etch-Litho-Etch and Sidewall Assisted Double Patterning, the number of processing step have increased significantly and therefore, so as the amount of metrology steps needed for both control and yield monitoring. The amount of metrology needed is increasing in each and every node as more layers needed multiple patterning steps, and more patterning steps per layer. In addition to this, there is that need for guided defect inspection, which in itself requires substantially denser focus, overlay, and CD metrology as before. Metrology efficiency will therefore be cruicial to the next semiconductor nodes. ASML's emulated wafer concept offers a highly efficient method for hybrid metrology for focus, CD, and overlay. In this concept metrology is combined with scanner's sensor data in order to predict the on-product performance. The principle underlying the method is to isolate and estimate individual root-causes which are then combined to compute the on-product performance. The goal is to use all the information available to avoid ever increasing amounts of metrology.
Intrusion detection system (2020)

IJET International Journal of Engineering and Techniques call for research papers international engineering science journal.IJET publishes is a peer reviewed,open access international scientific journal.IJET is rapid publication of high quality original research articles as well as review articles in engineering.IJET indexed Mendeley (developed by elsevier , scopus), worldCat, sjifactor, indexcopernicus, citefactor, google scholar, researchbib.