gebhart/patrepeval huggingface dataset:
Smart fast blood counting of trace volumes of body fluids from various mammalian species using a compact custom-built microscope cytometer(Conference Presentation) (2016)

Cell counting in human body fluids such as blood, urine, and CSF is a critical step in the diagnostic process for many diseases. Current automated methods for cell counting are based on flow cytometry systems. However, these automated methods are bulky, costly, require significant user expertise, and are not well suited to counting cells in fluids other than blood. Therefore, their use is limited to large central laboratories that process enough volume of blood to recoup the significant capital investment these instruments require. We present in this talk a combination of a (1) low-cost microscope system, (2) simple sample preparation method, and (3) fully automated analysis designed for providing cell counts in blood and body fluids. We show results on both humans and companion and farm animals, showing that accurate red cell, white cell, and platelet counts, as well as hemoglobin concentration, can be accurately obtained in blood, as well as a 3-part white cell differential in human samples. We can also accurately count red and white cells in body fluids with a limit of detection ~3 orders of magnitude smaller than current automated instruments. This method uses less than 1 microliter of blood, and less than 5 microliters of body fluids to make its measurements, making it highly compatible with finger-stick style collections, as well as appropriate for small animals such as laboratory mice where larger volume blood collections are dangerous to the animal’s health.
Variation of the orientational order parameter in a nematic liquid crystal-COANP-C70 composite structure (2005)

Behavior of the orientational order parameter in structures of the nematic liquid crystal (NLC)-organic donor-fullerene type was studied by pulsed 1H NMR techniques. In the NLC sensitized by a fullerenecontaining charge transfer complex, the order parameter at temperatures 10 K below the nematic-isotropic phase transition exhibits an increase and exceeds the value for the initial liquid crystal. This effect is not typical of nonmesogenic additives.
Discovery of 5-Amino- <i>N</i> -(1 <i>H</i> -pyrazol-4-yl)pyrazolo[1,5- <i>a</i> ]pyrimidine-3-carboxamide Inhibitors of IRAK4 (2015)

Interleukin-1 receptor associated kinase 4 (IRAK4) is an essential signal transducer downstream of the IL-1R and TLR superfamily, and selective inhibition of the kinase activity of the protein represents an attractive target for the treatment of inflammatory diseases. A series of 5-amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamides was developed via sequential modifications to the 5-position of the pyrazolopyrimidine ring and the 3-position of the pyrazole ring. Replacement of substituents responsible for poor permeability and improvement of physical properties guided by cLogD led to the identification of IRAK4 inhibitors with excellent potency, kinase selectivity, and pharmacokinetic properties suitable for oral dosing.
Implicit enumeration of strongly connected components and an application to formal verification (2000)

This paper first presents a binary decision diagram-based implicit algorithm to compute all maximal strongly connected components (SCCs) of directed graphs. The algorithm iteratively applies reachability analysis and sequentially identifies SCCs. Experimental results suggest that the algorithm dramatically outperforms the only existing implicit method which must compute the transitive closure of the adjacency-matrix of the graphs. This paper then applies this SCC algorithm to solve the bad cycle detection problem encountered in formal verification. Experimental results show that our new bad cycle detection algorithm is typically significantly faster than the state-of-the-art, sometimes by more than a factor of ten.
Cloning and Expression of cDNA Coding for the Major House Dust Mite Allergen<i>Der f</i>II in<i>Escherichia coli</i> (1991)

A cDNA library corresponding to mite protein was screened using anti-Der f II, a major allergen from the house dust mite Dermatophagoides farinae, antibody. Three possible clones were obtained that contained cDNA fragments coding for Der f II, and the nucleotide sequences of the fragments were determined. There were minor differences observed affecting the deduced amino acid sequence among the three cDNA fragments. The amino acid sequence of the purified native Der f II protein could be analyzed to 45 residues from the N-terminus. As a result of comparison, all the three cDNA fragments code for a mature protein with a derived molecular weight of about 14,000. The amino acid sequence was not homologous to any known protein sequences and it contained six cysteine residues and no N-glycosylation sites.
Sulfur derivatives of N,N‐Disubstituted amides of long chain fatty acids and their antimicrobial activities (1975)

Abstract Mercaptoacetic acid was added to the internal double bond of N,N‐disubstituted oleamides and the terminal double bond of 11‐undecenoylmorpholine. Unreacted starting materials were removed by distillation and as urea complexes. The internal carboxyl group of N,N‐disubstituted‐9(10)‐(carboxymethylthio)stearamides and the terminal carboxyl group of 11‐(carboxymethylthio)undecanamide were esterified. Screening for broad range antimicrobial activity against Candida albicans, Staphylococcus aureus, Escherichia coli , and Aspergillus species indicated that all compounds tested were active. However, 9(10)‐(carbomethoxymethylthio)stearoylmorpholine and 9(10)‐carbethoxymethylthio)stearoyl‐4‐methylpiperidine were the most effective and strongly inhibited the growth of all organisms tested.
Substitution and Condensation Reactions with Poly(anilineboronic acid):  Reactivity and Characterization of Thin Films (2005)

Poly(anilineboronic acid) thin films are treated under various conditions to achieve substitution or condensation reactions involving the boronic acid moiety. These reactions are studied with polarization modulated infrared reflection absorption spectroscopy, cyclic voltammetry, and UV-vis spectroscopy. The results suggest the single-step formation of substituted polyanilines, such as poly(hydroxyaniline), halogenated polyanilines, and mercury chloride-substituted polyaniline. A condensation reaction of poly(anilineboronic acid) with cis-diol compounds in aqueous solution, as well as with phenylenebisboronic acid and salycilamide in THF, indicates the formation of boronic esters. The latter reactions appear to be a good entry point for the formation of complex or supramolecular polymer structures.
Discovering spatio-temporal causal interactions in traffic data streams (2011)

The detection of outliers in spatio-temporal traffic data is an important research problem in the data mining and knowledge discovery community. However to the best of our knowledge, the discovery of relationships, especially causal interactions, among detected traffic outliers has not been investigated before. In this paper we propose algorithms which construct outlier causality trees based on temporal and spatial properties of detected outliers. Frequent substructures of these causality trees reveal not only recurring interactions among spatio-temporal outliers, but potential flaws in the design of existing traffic networks. The effectiveness and strength of our algorithms are validated by experiments on a very large volume of real taxi trajectories in an urban road network.
A sample-in-answer-out instrument for the detection of multiple respiratory pathogens in unprepared nasopharyngeal swab samples (2010)

Multiplex RT-PCR suspension array assays provide a powerful tool for identifying the causative agent(s) of respiratory infections. These assays are time consuming and laborious on a time-per-sample basis if only a few samples require processing. To address this shortcoming and provide an automated solution for fast detection and identification of viral pathogens, we developed the first automated multiplex RT-PCR suspension array instrument capable of handling unprepared clinical samples. The instrument requires less than 3 minutes of hands-on time for a result generated in approximately 2.5 hours. In analytical studies, the instrument performed as well as manually performed assays. The performance of the instrument and loaded multiplex viral detection assay was then tested using unprepared nasopharyngeal samples. The instrument-performed assay detected 61 of 71 RSV positive samples, for a sensitivity of 85.9%. Adenovirus (n = 5) and influenza B (n = 3) were less prevalent in the sample set, but detected to similar levels, 80% and 75%, respectively. The same sample set was also tested using FDA approved immuno-assay rapid tests, and the instrument was found to be more sensitive than the rapid tests with the sole exception being influenza A (n = 16), which was poorly detected due to significant sequence mismatches between the influenza A primer/probe set included in the multiplex mixture and the circulating influenza A strains. Overall, these data demonstrate the developed prototype platform performs multiplex array assays as well as hand-performed assays, and that the instrument's sensitivity and specificity are dictated by the quality of the loaded multiplex assay.
Accuracy of cardiac‐induced brain motion measurement using displacement‐encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI): A phantom study (2020)

Using a tissue phantom undergoing cyclical motion, we demonstrated the percent accuracy of DENSE MRI to measure displacement similar to that observed for in vivo cardiac-induced brain tissue.
Optical fibers with reduced pressure sensitivity (1981)

The pressure sensitivity of the phase of light propagating in aluminum-coated fibers is studied both analytically and experimentally. The analytically predicted reduction in fiber sensitivity that is due to the balancing of pressure-induced length changes with strain-induced index changes is demonstrated experimentally.
2413 Development of Insulation Distance Check Technique Using 3D Shape Data (2014)

In structural design for electronic equipments, it is difficult to check the insulation distance. Therefore, we are developing an insulation distance check technique using 3D shape data. Conventionally, structure designers visually inspected insulation distance or checked it by functions of CAD software. However, unintentional omissions and excessive detections of inspection objects were problems. In this research, we developed a distance map calculation technique and a shortest path extraction technique using voxel mesh. We compared the number of omissions and detections of this technique with the clearance check function of a CAD software. As a result, we confirmed that the number of omissions is zero and the number of excessive detections is less than that of the clearance check function of the CAD software. Accordingly, working time could be reduced by almost 60% of the conventional process.
Transverse-flux permanent magnet (TFPM) machine with toothed rotor (2002)

The geometry of the transverse flux permanent magnet machine with toothed rotor is derived. This new machine geometry allows easy production and low mass of active material. Experiments on a linear actuator are presented in the paper.
Wavelength Shifting in InP based Ultra-thin Quantum Well Infrared Photodetectors (1998)

We have demonstrated red-shifting of the wavelength response of a bound-to-continuum p-type ultra-thin InGaAs/Inp quantum well infrared photodetector after growth via rapid thermal annealing. Compared to the as-grown detector, the peak spectral response of the annealed detector was shifted to longer wavelength without any major degradation in responsivity characteristics.
Fast directional image interpolation with difference projection (2009)

This paper presents a new directional image interpolator, aiming to increase image resolution with high perceptual quality and low computational complexity. In our method, missing pixels in a magnified image are generated through linear interpolation on certain fixed supports to facilitate fast implementation, while local directional features are imposed on the adaptive interpolation weights which are determined by the gradients diffused from the low resolution image. Afterwards, a novel difference projection strategy is proposed to enforce the continuity of the magnified image by reusing the directional interpolator. Experimental results show that our method outperforms conventional bicubic and some existing adaptive interpolators, in terms of both the perceptual and quantitative quality.
Novel WDM-TDM semiconductor sources for optical communications and signal processing (2002)

Active modelocked diode lasers are used to generate a multiplicity of individual modelocked wavelengths (/spl sim/20) at single channel rates of 5 Gbit/s for data transmission and signal processing applications in hybrid WDM-TDM optical networks.
Controlled black liquor viscosity reduction through salting‐in (1996)

Abstract Black liquor viscosity increases exponentially with solids content and therefore causes processing problems for the paper industry by being a limiting factor in the Kraft pulp process. This study investigates a new approach for achieving viscosity reduction by “salting‐in” black liquor through the addition of thiocyanate salts. These salts generally increase the solubility of the polymer constituents in black liquor, leading to a decrease in its viscosity. Several thiocyanate salts capable of reducing liquor viscosity by more than two orders of magnitude have been identified, with viscosity reduction greatest at high solids content. Salting‐in of black liquor depends on the cation paired with the thiocyanate anion, as well as on solution pH and temperature. Comparative studies reveal that GuSCN is the most effective viscosity‐reducing agent of the series examined and that lignin plays an important role in the viscosity behavior of both unmodified and salted‐in black liquor at high solids concentrations. These experimental findings are interpreted in terms of the underlying principles that describe salting‐in and how it affects aqueous solution structure.
Amplification and molecular cloning of murine adenosine deaminase gene sequences. (1983)

A previously isolated mouse Cl-1D derived cell line (B-1/25) overproduces adenosine deaminase (EC 3.5.4.4) by 3200-fold. The present studies were undertaken to determine the molecular basis of this phenomenon. Rabbit reticulocyte lysate and Xenopus oocyte translation studies indicated that the B-1/25 cells also overproduced adenosine deaminase mRNA. Total poly(A+) RNA derived from B-1/25 was used to construct a cDNA library. After prehybridization with excess parental Cl-1D RNA to selectively prehybridize nonamplified sequences, 32P-labeled cDNA probe synthesized from B-1/25 total poly(A+) RNA was used to identify recombinant colonies containing amplified mRNA sequences. Positive clones containing adenosine deaminase gene sequences were identified by blot hybridization analysis and hybridization-selected translation in both rabbit reticulocyte lysate and Xenopus oocyte translation systems. Adenosine deaminase cDNA clones hybridized with three poly(A+) RNA species of 1.5, 1.7, and 5.2 kilobases in length, all of which were overproduced in the B-1/25 cell line. Dot blot hybridization analysis using an adenosine deaminase cDNA clone showed that the elevated adenosine deaminase level in the B-1/25 cells was fully accounted for by an increase in adenosine deaminase gene copy number. The adenosine deaminase cDNA probes and the cell lines with amplified adenosine deaminase genes should prove extremely useful in studying the structure and regulation of the adenosine deaminase gene.
Laser and Spectroscopic Properties of Yb-Doped Apatite Crystals (1993)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text L. D. DeLoach, S. A. Payne, W. F. Krupke, L. K. Smith, W. L. Kway, J. B. Tassano, and B. H. T. Chai, "Laser and Spectroscopic Properties of Yb-Doped Apatite Crystals," in Advanced Solid State Lasers, A. Pinto and T. Fan, eds., OSA Proceedings Series (Optica Publishing Group, 1993), paper LM3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Photoinduced Signal Amplification through Controlled Externally Sensitized Fragmentation in Masked Sensitizers (2006)

Addition of lithiated dithianes to diaryl ketones, potential electron-transfer sensitizers, disrupts conjugation between the two aromatic moieties, effectively masking the sensitizer. A novel photoamplification strategy is developed based on photosensitized cleavage in such adducts, where each fragmentation event releases more diaryl ketone, capable of sensitization. As a result, mass release of dithianes, triggered with a very small amount of the initiator, is observed. Such amplified release can be made contingent on a molecular recognition event, offering a promising methodology for high throughput bioanalytical applications. The concept is proved with the use of micro- and nanosized polymeric supports, including dendrimers.
The toner for low energy fusing by using crystalline polyester (2002)

To achieve the low energy fusing, the application of the crystalline polyester is studied. To compare with usual polyester, the crystalline polyester melts very quickly when it comes to the melting point. To compare with wax, crystalline polyester is very hard. So the toner that contains crystalline polyester can be fused in low energy but has enough durability.It is not popular yet because of some problems (One of the problems is poor storage stability because this resin is plasticizated for mixing usual resin, the other one is low anti-offset property because of low elasticity.) though.This report shows the properties of the toner that contains crystalline polyester, or how well that toner works for low energy fusing. In this study, the way to overcome problems of toner that contains crystalline polyester, or the better way to use crystalline polyester for toner is reported. e.g.1) Which melting point's crystalline polyester is better for toner. 2) How to control the dispersion size of the crystalline polyester. 3) Which dispersion size of the crystalline polyester is better for low energy fusing and storage ability.
Multispectral image visualization through first-order fusion (2002)

We present a new formalism for the treatment and understanding of multispectral images and multisensor imagery based on first-order contrast information. Although little attention has been paid to the utility of multispectral contrast, we develop a theory for multispectral contrast that enables us to produce an optimal grayscale visualization of the first-order contrast of an image with an arbitrary number of bands. We demonstrate how our technique can reveal significantly more interpretive information to an image analyst, who can use it in a number of image understanding algorithms. Existing grayscale visualization strategies are reviewed. A variety of experimental results are presented to support the performance of the new method.
Simultaneous coherent pulse stacking amplification and spatial combining of ultrashort pulses at multi-mJ energies (2022)

We demonstrate, to our knowledge, the first operation of a simultaneous spatial combining and CPSA system that provides 9mJ from two amplifier channels and coherently stacks 81 pulses to a single pulse and compresses the output to ~515fs duration. This demonstrates that CPSA with spatial coherent combining enables energy scaling of ultrashort pulses with fewer parallel channels. Future work will involve increasing energy per channel, average power per channel, the number of fiber channels and reducing the pulse duration.
Paper-Based Quantification of Male Fertility Potential (2016)

Our device outperforms existing commercial paper-based assays by quantitatively measuring live and motile sperm concentrations and motility, in only 10 min. This approach is applicable to current clinical practices as well as self-diagnostic applications.
Multi-core MgB<sub>2</sub> wire with a Ti barrier and a reinforced Al+Al<sub>2</sub>O<sub>3</sub> sheath (2018)

MgB2 is the lightest superconducting compound, which in connection with lightweight metals like Ti, used for a diffusion barrier and Al, used for an outer sheath, results in a superconducting wire with a noticeably reduced mass compared to traditional wires. Multi-core MgB2/Ti/Al+Al2O3 superconducting wire was manufactured by internal magnesium diffusion into a boron process. Basic electrical and mechanical properties of the multi-core wire were studied at low temperatures and compared with a single-core wire and also with GlidCop sheathed multi-core wires. It was found that the lightweight multi-core MgB2 wire exhibited a high critical current density and also a good tolerance to mechanical stresses. This predetermines the potential use of such a superconducting wire for applications where a reduction of the mass of the system is required.
Testbed for security orchestration in a network function virtualization environment (2017)

We present a testbed implementation for the development, evaluation and demonstration of security orchestration in a network function virtualization environment. As a specific scenario, we demonstrate how an intelligent response to DDoS and various other kinds of targeted attacks can be formulated such that these attacks and future variations can be mitigated. We utilise machine learning to characterise normal network traffic, attacks and responses, then utilise this information to orchestrate virtualized network functions around affected components to isolate these components and to capture, redirect and filter traffic (e.g. honeypotting) for additional analysis. This allows us to maintain a high level of network quality of service to given network functions and components despite adverse network conditions.
Coated foams, preparation, uses and articles (1982)

Hydrophobic cellular material is coated with a thin hydrophilic polymer skin which stretches tightly over the foam but which does not fill the cells of the foam, thus resulting in a polymer-coated foam structure having a smoothness which was not possible in the prior art. In particular, when the hydrophobic cellular material is a specially chosen hydrophobic polymer foam and is formed into arbitrarily chosen shapes prior to the coating with hydrophilic polymer, inertial confinement fusion (ICF) targets of arbitrary shapes can be produced by subsequently coating the shapes with metal or with any other suitable material. New articles of manufacture are produced, including improved ICF targets, improved integrated circuits, and improved solar reflectors and solar collectors. In the coating method, the cell size of the hydrophobic cellular material, the viscosity of the polymer solution used to coat, and the surface tension of the polymer solution used to coat are all very important to the coating.