gebhart/patrepeval huggingface dataset:
Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failureJames A. Bristol, Ila Sircar, Walter H. Moos, Dale B. Evans, and Ronald E. WeishaarCite this: J. Med. Chem. 1984, 27, 9, 1099–1101Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/jm00375a001https://doi.org/10.1021/jm00375a001research-articleACS PublicationsRequest reuse permissionsArticle Views313Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recent Advances in the Chemistry and Immunochemistry of Human Chorionic Gonadotropin: Impact on Clinical Measurements* (1994)

SINCE the discovery of human chorionic gonadotropin (hCG) by Hirose (1) and Ascheim and Zondek (2) nearly three quarters of a century ago, its measurement has been the basis of pregnancy diagnosis and, coincidentally, a marker for many trophoblastic and nontrophoblastic tumors, including some tumors of the testes (3). The first measurements of hCG were by biological activity, which restricted detection to the intact, heterodimeric molecule. The advent of immunoassays in the 1960s (4) permitted not only quantification of the parent molecule but also differential estimation of gonadotropin free subunits and fragments. Since then the isolation and characterization of an ever expanding spectrum of hCG-related molecular forms in blood and urine have begun to enlarge the scope of clinical applications served by their measurement. Variations in the hCG molecule isolated from biological fluids include the following: those affecting sialic acid content (5–7) or carbohydrate structure and composition (8–11), those influencing unusual free subunit concentrations in both pregnancy (12–16) and malignancy (17–22), and those reflecting β-subunit peptide bond cleavages (23–26) and fragmentation (27, 28). Some of these diverse hCG-associated molecular variants have potential clinical relevance.
Porous‐Organic‐Framework‐Templated Nitrogen‐Rich Porous Carbon as a More Proficient Electrocatalyst than Pt/C for the Electrochemical Reduction of Oxygen (2012)

Porous nitrogen-rich carbon (POF-C-1000) that was synthesized by using a porous organic framework (POF) as a self-sacrificing host template in a nanocasting process possessed a high degree of graphitization in an ordered structural arrangement with large domains and well-ordered arrays of carbon sheets. POF-C-1000 exhibits favorable electrocatalytic activity for the oxygen-reduction reaction (ORR) with a clear positive shift of about 40 mV in the onset potential compared to that of a traditional, commercially available Pt/C catalyst. In addition, irrespective of its moderate surface area (785 m(2) g(-1)), POF-C-1000 showed a reasonable H(2) adsorption of 1.6 wt % (77 K) and a CO(2) uptake of 3.5 mmol g(-1) (273 K).
Generalized Frequency Division Multiplexing With Flexible Index Modulation Numerology (2018)

In this letter, generalized frequency division multiplexing (GFDM) is combined with index modulation (IM) exploiting the block-based structure of GFDM in an innovative way. The proposed GFDM-IM scheme uses flexible IM numerology to reduce out-of-band (OOB) emission and provides a novel multilayer system model to further benefit from the enhanced distance spectrum of IM. The proposed scheme adapts maximum likelihood successive interference cancellation based near-optimum detector to improve the error performance and reduce the computational complexity. It has been shown that the proposed GFDM-IM scheme achieves better error performance than classical and IM-based orthogonal frequency division multiplexing and GFDM schemes at the same spectral efficiency, and provides an interesting tradeoff among OOB emission, spectral efficiency, and latency.
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units (2006)

Combinatorial biosynthesis of type I polyketide synthases is a promising approach for the generation of new structural derivatives of polyketide-containing natural products. A target of this approach has been to change the extender units incorporated into a polyketide backbone to alter the structure and activity of the natural product. One limitation to these efforts is that only four extender units were known: malonyl-CoA, methylmalonyl-CoA, ethylmalonyl-CoA, and methoxymalonyl-acyl carrier protein (ACP). The chemical attributes of these extender units are quite similar, with the exception of the potential hydrogen bonding interactions by the oxygen of the methoxy moiety. Furthermore, the incorporated extender units are not easily modified by using simple chemical approaches when combinatorial biosynthesis is coupled to semisynthetic chemistry. We recently proposed the existence of two additional extender units, hydroxymalonyl-ACP and aminomalonyl-ACP, involved in the biosynthesis of zwittermicin A. These extender units offer unique possibilities for combinatorial biosynthesis and semisynthetic chemistry because of the introduction of free hydroxyl and amino moieties into a polyketide structure. Here, we present the biochemical and mass spectral evidence for the formation of these extender units. This evidence shows the formation of ACP-linked extender units for polyketide synthesis. Interestingly, aminomalonyl-ACP formation involves enzymology typically found in nonribosomal peptide synthesis.
Detecting Blood Laboratory Errors Using a Bayesian Network (2010)

A Bayesian network is better at detection and can detect errors with less information than existing automated models, suggesting that Bayesian model may be an effective means for reducing medical costs and improving patient safety.
Performance of high-rate adaptive equalization on a shallow water acoustic channel (1996)

Multipath propagation in underwater acoustic channels causes intersymbol interference in the transmission of digital communication signals. An increase of the transmission rate on a multipath channel results in longer intersymbol interference, which ultimately limits the performance of a phase-coherent digital communication system. Recent experimental results, however, show a seemingly surprising result: an increase in transmission rate resulted in improved system performance. An explanation for this phenomenon is found in the time variation of the ocean multipath. In strongly fluctuating shallow water channels, higher transmission rates allow for more frequent sampling of the rapidly varying channel, thus resulting in a better tracking capability of the receiver. Experimental results obtained in shallow water show a substantial improvement in performance of QPSK coherent detection over a 1-mile range, as the data rate is increased from 5 to 20 kilobits per second. A theoretical analysis based on stochastic channel modeling supports the experimental observations.
320-channel dual phase lock-in optical spectrometer (2004)

The development of a multiple-channel lock-in optical spectrometer (LIOS) is presented, which enables parallel phase-sensitive detection at the output of an optical spectrometer. The light intensity from a spectrally broad source is modulated at the reference frequency, and focused into a high-resolution imaging spectrometer. The height at which the light enters the spectrometer is controlled by an acousto-optic deflector, and the height information is preserved at the output focal plane. A two-dimensional InGaAs focal plane array collects light that has been dispersed in wavelength along the horizontal direction, and in time along the vertical direction. The data is demodulated using a high performance computer-based digital signal processor. This parallel approach greatly enhances (by more than 100x) the speed at which spectrally resolved lock-in data can be acquired. The noise performance of a working system optimized for the 1.3 μm wavelength range is analyzed using a laser diode light source. Time-resolved absorption traces are obtained for InAs quantum dots embedded in a GaAs matrix, and for dispersed films of PbSe nanocrystals.
TRACKING SUSTAINED CHAOS (2000)

Tracking unstable periodic states first introduced in [Schwartz & Triandaf, 1992] is the process of continuing unstable solutions as a systems parameter is varied in experiments. The tracked dynamical objects have been periodic saddles of well-defined finite periods. However, other saddles, such as chaotic saddles, have not been successfully "tracked," or continued. In this paper, we introduce a new yet simple method which can be used to track chaotic saddles in dynamical systems, which allows an experimentalist to sustain chaotic transients far away from crisis parameter values. The method is illustrated on a periodically driven CO 2 laser.
In vitro inhibition of the infectivity and replication of human immunodeficiency virus type 1 by combination of antiretroviral 2',3'-dideoxynucleosides and virus-binding inhibitors (1990)

We tested the in vitro inhibitory activities of three 2',3'-dideoxynucleosides and two inhibitors of viral binding in combinations against the infectivity and cytopathic effect of human immunodeficiency virus type 1. 3'-Azido-2',3'-dideoxythymidine, 2',3'-dideoxyinosine, or 2',3'-dideoxycytidine, combined with recombinant soluble CD4 (sCD4), brought about synergistic antiretroviral activity without toxicity at clinically achievable concentrations. Combinations of 2',3'-dideoxynucleosides plus dextran sulfate exerted similar synergistic antiviral effects without concomitant increases in toxicities. When sCD4 and dextran sulfate were combined, apparent antagonism was observed. We confirmed that no combination of sCD4 plus 3'-azido-2',3'-dideoxythymidine, 2',3'-dideoxyinosine, or 2',3'-dideoxycytidine significantly increased the inhibitory effect on colony formation of human myeloid-monocytic bone marrow cells in vitro at the concentrations used in this study. These data might have clinical relevance for the treatment of patients infected with human immunodeficiency virus.
Learning-Based Sampling for Natural Image Matting (2019)

The goal of natural image matting is the estimation of opacities of a user-defined foreground object that is essential in creating realistic composite imagery. Natural matting is a challenging process due to the high number of unknowns in the mathematical modeling of the problem, namely the opacities as well as the foreground and background layer colors, while the original image serves as the single observation. In this paper, we propose the estimation of the layer colors through the use of deep neural networks prior to the opacity estimation. The layer color estimation is a better match for the capabilities of neural networks, and the availability of these colors substantially increase the performance of opacity estimation due to the reduced number of unknowns in the compositing equation. A prominent approach to matting in parallel to ours is called sampling-based matting, which involves gathering color samples from known-opacity regions to predict the layer colors. Our approach outperforms not only the previous hand-crafted sampling algorithms, but also current data-driven methods. We hence classify our method as a hybrid sampling- and learning-based approach to matting, and demonstrate the effectiveness of our approach through detailed ablation studies using alternative network architectures.
Detection of <i>Porphyromonas gingivalis</i> in Gingival Exudate by a Dipeptide‐Enhanced Trypsin‐Like Activity (1994)

Porphyromonas gingivalis in subgingival plaque is an important risk factor for future periodontal attachment loss in susceptible adults. The elimination of P. gingivalis is usually concomitant with a healing process. Therefore, it should be valuable to have an easy chairside method to follow the effect of periodontal treatment on P. gingivalis detection as well as on its eventual reappearance during the maintenance period. We have previously reported the stimulation of amidolytic activity of P. gingivalis by the addition of glycyl-glycine to the assay buffer. In this study we determined the proportions of P. gingivalis, Prevotella intermedia, Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga spp, Campylobacter rectus, and Eikenella corrodens by cultivation technique and the amidolytic activity, using N-benzoyl-L-arginine-p-nitroanilide (BAPNA) as substrate, in gingival exudate before and during a 3-year treatment and maintenance period. P. gingivalis was the only species yielding a high and persistent correlation to stimulated amidolytic activity (P values < or = 0.0001) on both site (r = 0.5) and subject (r = 0.8) level. Testing pure cultures of suggested periodontal pathogens for effect of glycyl-glycine on amidolytic activity, we found that of P. gingivalis to be 5.9-fold increased. The amidolytic activity of Treponema denticola was only slightly stimulated (ratio with/without glycyl-glycine = 1.2) and that of Capnocytophaga slightly inhibited (ratio with/without glycyl-glycine = 0.8). The outcome of this study has the potential to be used for the development of a simple, rapid, and inexpensive assay for a qualitative and quantitative determination of P. gingivalis in gingival crevicular fluid.
A 2.5-mW SOS CMOS Optical Receiver for Chip-to-Chip Interconnect (2004)

This paper reports on the design of a differential optical receiver in silicon-on-sapphire (SOS) complementary metal-oxide-semiconductor (CMOS). The low-power characteristics (2.5 mW) and small footprint make it a good candidate for two-dimensional optoelectronic interchip interconnects where the transparency of the substrate facilitates system integration and packaging. A differential transimpedance amplifier (TIA) with positive feedback at the front end extends the bandwidth of traditional differential TIAs when the capacitance of the photodetector is smaller than the capacitance of the gates in the differential pair. The full receiver tested in the 0.5-/spl mu/m ultrathin silicon (UTSi) SOS-CMOS Peregrine process consumes 2.5 mW when operated at or near gigabit rates, with bit-error rates of better than 10/sup -12/ taken at 750 Mb/s.
Semi-preemptible locks for a distributed file system (2002)

Many applications require the ability to obtain exclusive access to data, where an application is granted privileges to an object that cannot be preempted and limits the actions of other processes. Local file systems support exclusive access to files by maintaining information about the access rights of current open file instances, and checking subsequent opens for compatibility. Implementing exclusive access in this manner for distributed file systems degrades performance by requiring every open file to be registered with a server that maintains global open state. We introduce a distributed lock for managing file access, called a semi-preemptible lock, that avoids this performance limitation. Clients locally grant open requests for files that are consistent with a distributed semipreemptible lock that they hold. File system clients retain or cache distributed locks, even in the absence of open file instances. When a file access lock is already cached, a client services open requests. Without a server message, improving performance by exploiting locality, the affinity of files to clients.
Direct estimation of tracer‐kinetic parameter maps from highly undersampled brain dynamic contrast enhanced MRI (2016)

Model-based direct estimation of TK maps from k,t-space DCE-MRI data is feasible and is compatible up to 100-fold undersampling. Magn Reson Med 78:1566-1578, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Synthesis of Spherical Core‐Shell PVAc‐<i>co</i>‐PMMA/PVA Particles for Use in Vascular Embolization (2011)

Abstract Previous published works described suspension polymerization processes for the production of spherical core‐shell poly(vinyl acetate)/poly(vinyl alcohol) (PVAc/PVA) particles with regular morphology for use as embolic agents in vascular embolization procedures. Although the clinical performance of the produced particles was regarded as excellent, the produced PVAc/PVA particles were prone to agglomeration during storage. For this reason, methyl methacrylate is now used as comonomer in order to increase the glass transition temperature of the final product and prevent agglomeration of polymer particles. The final expansion of particles, intended to control the density of the polymer beads, also exerts a beneficial effect on the rate of particle agglomeration. Therefore, a methodology to obtain spherical poly(vinyl acetate)‐co‐poly(methyl methacrylate)/poly(vinyl alcohol) (PVAc‐co‐PMMA/PVA) particles with core‐shell structure is presented in this work.
Analysis of Antigenic Structure and Human Immune Response to Outer Membrane Protein CD of <i>Moraxella catarrhalis</i> (1999)

Moraxella catarrhalis is an important cause of otitis media in children and lower respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). Outer membrane protein CD (OMP CD) is a 45-kDa protein which is a potential vaccine antigen to prevent infections caused by M. catarrhalis. Eight monoclonal antibodies were used to study the antigenic structure of the OMP CD molecule by assaying recombinant peptides corresponding to the sequence of the protein. This approach identified two surface-exposed epitopes, including one near the amino terminus (amino acids 25 to 44) and one in the central region of the molecule (amino acids 261 to 331). Assays with serum and sputum supernatants of adults with COPD revealed variable levels of antibodies to OMP CD among individuals. To determine which portions of the OMP CD molecule were recognized by human antibodies, three human serum samples were studied with six recombinant peptides which span the sequence of OMP CD. All three sera contained immunoglobulin G antibodies which recognized exclusively the peptide corresponding to amino acids 203 to 260 by immunoblot assay. Adsorption experiments with whole bacteria established that some of the human antibodies are directed at surface-exposed epitopes on OMP CD. We conclude that OMP CD is a highly conserved molecule which contains at least two separate epitopes which are exposed on the bacterial surface. While individual adults with COPD show variability in the immune response to OMP CD, a specific region of the OMP CD molecule (amino acids 203 to 260) is important as a target of the human immune response.
Distinct genomic aberrations associated with <i>ERG</i> rearranged prostate cancer (2009)

Emerging molecular and clinical data suggest that ETS fusion prostate cancer represents a distinct molecular subclass, driven most commonly by a hormonally regulated promoter and characterized by an aggressive natural history. The study of the genomic landscape of prostate cancer in the light of ETS fusion events is required to understand the foundation of this molecularly and clinically distinct subtype. We performed genome-wide profiling of 49 primary prostate cancers and identified 20 recurrent chromosomal copy number aberrations, mainly occurring as genomic losses. Co-occurring events included losses at 19q13.32 and 1p22.1. We discovered three genomic events associated with ERG rearranged prostate cancer, affecting 6q, 7q, and 16q. 6q loss in nonrearranged prostate cancer is accompanied by gene expression deregulation in an independent dataset and by protein deregulation of MYO6. To analyze copy number alterations within the ETS genes, we performed a comprehensive analysis of all 27 ETS genes and of the 3 Mbp genomic area between ERG and TMPRSS2 (21q) with an unprecedented resolution (30 bp). We demonstrate that high-resolution tiling arrays can be used to pin-point breakpoints leading to fusion events. This study provides further support to define a distinct molecular subtype of prostate cancer based on the presence of ETS gene rearrangements.
Fluorescent DNA base replacements: reporters and sensors for biological systems (2006)

We describe the design, synthesis, and properties of nucleoside monomers in which the DNA base is replaced by fluorescent hydrocarbons and heterocycles, and the assembly of these monomers into DNA-like molecules in which the all bases are fluorescent. As monomers, such molecules have useful applications as reporters in the DNA context. The use of fluorescent DNA bases, rather than more traditional fluorophores tethered to the DNA strand, gives a more predictable location and orientation, and yields a more direct response to changes that occur within the helix. In addition to uses as monomers, such compounds can be assembled into polychromophoric oligomers ("oligodeoxyfluorosides" or ODFs). ODFs are water soluble, discrete molecules and are easily arranged into specific sequences by use of a DNA synthesizer. They have displayed a number of properties not readily available in commercial fluorophores, including large Stokes shifts, tunable excitation and emission wavelengths, and sensing responses to physical changes or molecular species in solution. We describe an approach to assembling and screening large sets of oligofluorosides for rapid identification of molecules with desirable properties. Such compounds show promise for applications in biochemistry, biology, environmental and materials applications.
Synthesis and Fungicidal Activity of Hydrated Geranylated Phenols against Botrytis cinerea (2021)

<i>Botrytis cinerea</i> is a ubiquitous fungus that affects hundreds of plants, resulting in economic losses to the horticulture and fruit industry. The search for new antifungal agents is a matter of current interest. Thus, in this work a series of geranylated phenols in which the side alkyl chain has been hydrated have been synthesized, and their activity against <i>B. cinerea</i> has been evaluated. The coupling of phenol and geraniol has been accomplished under microwave irradiation obtaining the highest reaction yields in the shortest reaction times. Hydration of the side chain was carried out in dioxane with <i>p</i>-toluenesulfonic acid polymer-bound as the catalyst. All synthesized compounds were tested against <i>B. cinerea</i> using the growth inhibition assay and EC<sub>50</sub> values were determined. The results show that activity depends on the number and nature of functional groups in the phenol ring and hydration degree of the geranyl chain. The most active compound is 1,4-dihydroquinone with one hydroxyl group attached at the end of the alkyl chain. Results from a molecular docking study suggest that hydroxyl groups in the phenol ring and alkyl chain are important in the binding of compounds to the active site, and that the experimental antifungal activity correlates with the number of H-bond that can be formed in the binding site.