gebhart/patrepeval huggingface dataset:
Multi-GHz Frequency Synthesis & Division: Frequency Synthesizer Design for 5 GHz Wireless LAN Systems (2001)

There has been an increasing demand for Wireless Local Area Network (WLAN) systems in the past few years. New frequency bands are allocated and new standards are being developed to accommodate higher data rates. The fast trend of CMOS scaling has provided an opportunity for the development of low cost integrated WLAN systems. Frequency synthesizers are one of the main building blocks of wireless transceivers. The high frequency digital frequency dividers in a phase-locked loop (PLL) based frequency synthesizer are among the most challenging blocks to design and usually account for a large percentage of the synthesizer total power dissipation. The successful design and integration of a high frequency PLL demands a comprehensive understanding of wireless systems, RF circuits, and loop stability issues. Multi-GHz Frequency Synthesis & Division starts with an overview of WLAN systems and reviews the WLAN market and standards. It then studies PLLs as an essential building block of WLAN receivers, and provides guidelines and engineering recipes for the design of loop filters in high frequency PLLs. Additionally, the book investigates different analog and digital frequency division techniques and introduces injection-locked frequency dividers (ILFDs) as an alternative for conventional frequency dividers. Finally, the book demonstrates a successful design of a fully integrated CMOS frequency synthesizer for a 5 GHz WLAN receiver. Multi-GHz Frequency Synthesis & Division will be of interest to RF and high-speed analog circuit designers and students as well as wireless engineers.
Blue fluorescent emitters: design tactics and applications in organic light-emitting diodes (2013)

Organic light-emitting diodes (OLEDs) are competitive candidates for the next generation flat-panel displays and solid state lighting sources. Efficient blue-emitting materials have been one of the most important prerequisites to kick off the commercialization of OLEDs. This tutorial review focuses on the design of blue fluorescent emitters and their applications in OLEDs. At first, some typical blue fluorescent materials as dopants are briefly introduced. Then nondoped blue emitters of hydrocarbon compounds are presented. Finally, the nondoped blue emitters endowed with hole-, electron- and bipolar-transporting abilities are comprehensively reviewed. The key issues on suppressing close-packing, achieving pure blue chromaticity, improving thermal and morphological stabilities, manipulating charge transporting abilities, simplifying device structures and the applications in panchromatic OLEDs are discussed.
[The effects of cytokines mediated ex vivo expansion on the cell adhesion molecule expression of cord blood hematopoietic stem and progenitor cells]. (2002)

Our short-term culture system can not merely support the simultaneous expansion of CB derived AC133+ cells, but the expanded hematopoietic progenitors may well sustained the expression of homing-related adhesion molecules.
Experimental and Computational Investigations of Oxygen Reactivity in a Heme and Tyrosyl Radical-Containing Fatty Acid α-(Di)oxygenase (2011)

Rice α-(di)oxygenase mediates the regio- and stereospecific oxidation of fatty acids using a persistent catalytic tyrosyl radical. Experiments conducted in the physiological O(2) concentration range, where initial hydrogen atom abstraction from the fatty acid occurs in a kinetically reversible manner, are described. Our findings indicate that O(2)-trapping of an α-carbon radical is likely to reversibly precede reduction of a 2-(R)-peroxyl radical intermediate in the first irreversible step. A mechanism of concerted proton-coupled electron transfer is proposed on the basis of natural abundance oxygen-18 kinetic isotope effects, deuterium kinetic isotope effects, and calculations at the density functional level of theory, which predict a polarized transition state in which electron transfer is advanced to a greater extent than proton transfer. The approach outlined should be useful for identifying mechanisms of concerted proton-coupled electron transfer in a variety of oxygen-utilizing enzymes.
Liquid-crystalline polyethers based on conformational isomerism. 10. Synthesis and determination of the virtual mesophases of polyethers based on 1-(4-hydroxyphenyl)-2-(2-methyl-4-hydroxyphenyl)ethane and .alpha.,.omega.-dibromoalkanes containing from 17 to 20 methylene units (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid-crystalline polyethers based on conformational isomerism. 10. Synthesis and determination of the virtual mesophases of polyethers based on 1-(4-hydroxyphenyl)-2-(2-methyl-4-hydroxyphenyl)ethane and .alpha.,.omega.-dibromoalkanes containing from 17 to 20 methylene unitsVirgil Percec and Y. TsudaCite this: Macromolecules 1990, 23, 14, 3509–3520Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ma00216a020https://doi.org/10.1021/ma00216a020research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A fast 35-GHz time-resolved EPR apparatus (1993)

A time-resolved Q-band (35-GHz) electron paramagnetic resonance (EPR) apparatus with a 25-ns rise time and 10-ns time resolution is described. Built around the Varian E110 microwave bridge, a detailed description of the resonator, flow system, optical alignment, and preamplifier electronics is given. The resonator is a TE103 rectangular cavity with front and back cutoff flanges attached to allow maximum laser light access. An adjustable Gordon coupler was constructed to achieve critical coupling to the cavity. Two separate designs of quartz sample flow cell are described, one for low dielectric organic solvents and one for aqueous samples. The standard diode detection system as shipped by Varian was used, but the signal from the detector diode was branched into two separate amplifiers, one the standard preamplifier for automatic frequency control lock-in operation, the other based on a Comlinear op-amp which gave fast rise times (9 ns) before the signal was trapped by a boxcar signal averager. Test systems clearly showed that the instrument response is no longer limited by the quality factor of the cavity but by the laser pulse width and jitter. Strong, spin-polarized EPR signals from the photolysis of dimethoxyphenylacetophenone, which were well separated due to their large g-factor difference, were distinguished at sampling delay times as early as 10 ns after the laser flash producing the radicals. A sensitivity comparison to X-band is made using the acetone/2-propanol system.
Expression of Nestin by Neural Cells in the Adult Rat and Human Brain (2011)

Neurons and glial cells in the developing brain arise from neural progenitor cells (NPCs). Nestin, an intermediate filament protein, is thought to be expressed exclusively by NPCs in the normal brain, and is replaced by the expression of proteins specific for neurons or glia in differentiated cells. Nestin expressing NPCs are found in the adult brain in the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus. While significant attention has been paid to studying NPCs in the SVZ and SGZ in the adult brain, relatively little attention has been paid to determining whether nestin-expressing neural cells (NECs) exist outside of the SVZ and SGZ. We therefore stained sections immunocytochemically from the adult rat and human brain for NECs, observed four distinct classes of these cells, and present here the first comprehensive report on these cells. Class I cells are among the smallest neural cells in the brain and are widely distributed. Class II cells are located in the walls of the aqueduct and third ventricle. Class IV cells are found throughout the forebrain and typically reside immediately adjacent to a neuron. Class III cells are observed only in the basal forebrain and closely related areas such as the hippocampus and corpus striatum. Class III cells resemble neurons structurally and co-express markers associated exclusively with neurons. Cell proliferation experiments demonstrate that Class III cells are not recently born. Instead, these cells appear to be mature neurons in the adult brain that express nestin. Neurons that express nestin are not supposed to exist in the brain at any stage of development. That these unique neurons are found only in brain regions involved in higher order cognitive function suggests that they may be remodeling their cytoskeleton in supporting the neural plasticity required for these functions.
Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase. (1979)

A fragment of glucagon encompassing its first six NH2-terminal residues (His-Ser-Gln-Gly-Thr-Phe) binds to the glucagon receptor and stimulates adenylate cyclase activity in rat liver plasma membranes. Glucagon1-6 is a partial agonist since it stimulates, at saturating concentrations, to the extent of 75% of the maximal activity given by the native hormone. The binding affinity and potency of glucagon1-6 are 0.001% the native hormone. Discussed are the implications of these findings on the structure-function relationships required for the action of glucagon and for preparing clinically useful analogs of the hormone.
Biology of Dairy Cows During the Transition Period: the Final Frontier? (1999)

The transition period, from 3 wk before to 3 wk after parturition, is critically important to health, production, and profitability of dairy cows. Most health disorders occur during this time. Compared with other stages of the lactation cycle, relatively little is known about fundamental biological processes during the transition period. The regulation and coordination of lipid metabolism among adipose tissue, liver, gut, and mammary gland are key components of the adaptations to lactation. Lipid accumulation in liver may contribute to health disorders and decreased milk production. Knowledge of key control points in hepatic metabolism of long-chain fatty acids is lacking, as is an understanding of the metabolic effects of hormones, growth factors, and cytokines that mediate stress. Recent evidence indicates that supplemental fats or restricted intakes before parturition can induce a coordinated set of metabolic changes in metabolism of long-chain fatty acids, including peroxisomal beta-oxidation, perhaps mediated by peroxisome proliferator-activated receptors. Estimates of the mixture of fuels constituting metabolizable energy in cows during the early postpartum period suggest that supply of amino acids and glucogenic compounds may be under proposed optima, whereas ketogenic and lipogenic compounds and long-chain fatty acids may be in excess. Because dietary fat does not suppress body lipid mobilization, during the early postpartum period supplemental fat may further imbalance the mixture of fuels and lead to decreased dry matter intake. Increased understanding of the biology of the transition period should decrease health problems and increase profitability of dairy cows.
Low power multimedia (2006)

Multimedia processing is becoming a critical requirement and a major driver of present day and future consumer electronics equipment such as game consoles, mobile handsets, home entertainment systems, etc. With the availability of increasing data bandwidth, there is a greater demand for much more advanced multimedia processing capabilities, which in turn translates to higher computational and storage requirements on these devices. Compounding this challenge is the ever increasing demand for mobility, dictating that these multimedia functions be performed at the lowest levels of power consumption.
Heterogeneous Expression of Drosophila Gustatory Receptors in Enteroendocrine Cells (2011)

The gastrointestinal tract is emerging as a major site of chemosensation in mammalian studies. Enteroendocrine cells are chemosensory cells in the gut which produce regulatory peptides in response to luminal contents to regulate gut physiology, food intake, and glucose homeostasis, among other possible functions. Increasing evidence shows that mammalian taste receptors and taste signaling molecules are expressed in enteroendocrine cells in the gut. Invertebrate models such as Drosophila can provide a simple and genetically tractable system to study the chemosensory functions of enteroendocrine cells in vivo. To establish Drosophila enteroendocrine cells as a model for studying gut chemosensation, we used the GAL4/UAS system to examine the expression of all 68 Gustatory receptors (Grs) in the intestine. We find that 12 Gr-GAL4 drivers label subsets of enteroendocrine cells in the midgut, and examine colocalization of these drivers with the regulatory peptides neuropeptide F (NPF), locustatachykinin (LTK), and diuretic hormone 31 (DH31). RT-PCR analysis provides additional evidence for the presence of Gr transcripts in the gut. Our results suggest that the Drosophila Grs have chemosensory roles in the intestine to regulate physiological functions such as food uptake, nutrient absorption, or sugar homeostasis.
A piezoelectric respiratory monitor for <i>in vivo</i> nmr (1992)

This report describes a simple electronic device employing a piezoelectric element which serves as a sensitive detector of motion. The device is useful as a monitor of respiratory motion for nuclear magnetic resonance animal experiments in vivo. It can also provide a trigger pulse for respiratory gating experiments.
Association Study of the <b><i>TREM2 </i></b>Gene and Identification of a Novel Variant in Exon 2 in Iranian Patients with Late-Onset Alzheimer's Disease (2015)

The rs75932628-T allele frequency in the elderly Iranian population (0.86%) was high.
A Parallel Synthesis Demonstration Library of Tri-Substituted Indazoles Containing New Antimutagenic / Antioxidant Hits Related to Benzydamine (2003)

A solution phase strategy for the multiple parallel synthesis of a demonstration library of indazoles is described by which regio-selectivity problems inherent to previous syntheses of this nucleus are largely overcome. Synthesis of selected components proceeded satisfactorily indicating that a fully realized library of indazole analogs could readily be produced using this methodology. Simple modifications of the basic nucleophilic aromatic substitution route unambiguously produce a range of N-1 substitutions (alkyl, aryl and aralkyl) in 50-75% yields. Next a range of substituents was introduced at the C-3 position in 50-80% yields by O-alkylation. Careful choice of reagents and reaction conditions were required to prevent by-product formation due to competing alkylation at N-2 (trace to 15% yields). When present, these contaminants were readily removed by chromofiltration. A third diversity site was sketched in at C-5 in 75-90% yield by reductive alkylation or acylation. Screening of some of the demonstration library members in vitro revealed highly active antioxidants suggesting that producing a full library would be worthwhile.
Factors influencing pregnancy rates in intrauterine insemination cycles. (2008)

Other than clinical and laboratory characteristics, only the number of preovulatory follicles and the percentage of normal sperm morphology in processed sperm can be used in the prediction of a favorable IUI outcome.
An Overview of Micro- and Nanoemulsions as Vehicles for Essential Oils: Formulation, Preparation and Stability (2020)

The interest around essential oils is constantly increasing thanks to their biological properties exploitable in several fields, from pharmaceuticals to food and agriculture. However, their widespread use and marketing are still restricted due to their poor physico-chemical properties; i.e., high volatility, thermal decomposition, low water solubility, and stability issues. At the moment, the most suitable approach to overcome such limitations is based on the development of proper formulation strategies. One of the approaches suggested to achieve this goal is the so-called encapsulation process through the preparation of aqueous nano-dispersions. Among them, micro- and nanoemulsions are the most studied thanks to the ease of formulation, handling and to their manufacturing costs. In this direction, this review intends to offer an overview of the formulation, preparation and stability parameters of micro- and nanoemulsions. Specifically, recent literature has been examined in order to define the most common practices adopted (materials and fabrication methods), highlighting their suitability and effectiveness. Finally, relevant points related to formulations, such as optimization, characterization, stability and safety, not deeply studied or clarified yet, were discussed.
A 57-Year-Old African American Man with Severe COVID-19 Pneumonia Who Responded to Supportive Photobiomodulation Therapy (PBMT): First Use of PBMT in COVID-19 (2020)

BACKGROUND Coronavirus disease 2019 (COVID-19) is associated with lung inflammation and cytokine storm. Photobiomodulation therapy (PBMT) is a safe, non-invasive therapy with significant anti-inflammatory effects. Adjunct PBMT has been employed in treating patients with lung conditions. Human studies and experimental models of respiratory disease suggest PBMT reduces inflammation and promotes lung healing. This is the first time supportive PBMT was used in a severe case of COVID-19 pneumonia. CASE REPORT A 57-year-old African American man with severe COVID-19 received 4 once-daily PBMT sessions by a laser scanner with pulsed 808 nm and super-pulsed 905 nm modes for 28 min. The patient was evaluated before and after treatment via radiological assessment of lung edema (RALE) by CXR, pulmonary severity indices, blood tests, oxygen requirements, and patient questionnaires. Oxygen saturation (SpO₂) increased from 93-94% to 97-100%, while the oxygen requirement decreased from 2-4 L/min to 1 L/min. The RALE score improved from 8 to 5. The Pneumonia Severity Index improved from Class V (142) to Class II (67). Additional pulmonary indices (Brescia-COVID and SMART-COP) both decreased from 4 to 0. CRP normalized from 15.1 to 1.23. The patient reported substantial improvement in the Community-Acquired Pneumonia assessment tool. CONCLUSIONS This report has presented supportive PBMT in a patient with severe COVID-19 pneumonia. Respiratory indices, radiological findings, oxygen requirements, and patient outcomes improved over several days and without need for a ventilator. Future controlled clinical trials are required to evaluate the effects of PBMT on clinical outcomes in patients with COVID-19 pneumonia.
Multi-stage, isothermal CO preferential oxidation reactor (2001)

A multi-stage, isothermal, carbon monoxide preferential oxidation (PrOx) reactor comprising a plurality of serially arranged, catalyzed heat exchangers, each separated from the next by a mixing chamber for homogenizing the gases exiting one heat exchanger and entering the next. In a preferred embodiment, at least some of the air used in the PrOx reaction is injected directly into the mixing chamber between the catalyzed heat exchangers.
Effect of anodic growth temperature on native oxides of <i>n</i>-(Hg, Cd)Te (1983)

The insulating behavior of anodically grown native oxides on Cd0.23Hg0.77Te can be improved considerably by performing the anodic process at increased temperatures. For the first time, anodic oxides were grown at 50 °C in the standard ethylene glycol-KOH-electrolyte which show a reduction in the high-frequency (1 MHz) conductivity of the order of one magnitude respective to our room-temperature grown oxides. A high electrical breakdown voltage (1.5 MV/cm) and a decreased hysteresis shift (50 mV) underline these results. Other oxide parameters such as fixed oxide charges and fast surface states and the excellent dc resistivity remain practically unchanged. Subroom-temperature grown oxides, however, are extremely unstable.
Context and regulation of homeschooling: Issues, evidence, and assessment practices. (2020)

The article discusses salient factors that influence the current context within which homeschooling occurs. Individual states have applied various approaches to establish regulations that both preserve the rights of homeschooling parents and fulfill the state's obligation to ensure that its residents receive the education to which they are constitutionally entitled. Case and ethnographic studies or research involving small and selected samples often appear in outlets associated with homeschool advocacy groups or in outlets that are not mainstream. The paucity of empirical evidence derived from methodologically strong research paradigms has led to little certainty about many aspects of homeschooling, including its effectiveness in preparing an educated citizenry. From state to state, the understanding and definition of homeschooling vary widely, leading to equally wide variations in regulatory practices. The article documents and summarizes state-to-state variations in matters pertaining to homeschooling and offers recommendations to help school psychologists work more effectively with students who are educated at home. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
Post-Transcriptional Regulation of Transforming Growth Factor Beta-1 by MicroRNA-744 (2011)

Transforming Growth Factor Beta-1 (TGF-β1) is a pleiotropic cytokine that is of central importance in wound healing, inflammation, and in key pathological processes including cancer and progressive tissue fibrosis. TGF-β1 is post-transcriptionally regulated, but the underlying mechanisms remain incompletely defined. Previously, we have extensively delineated post-transcriptional regulation of TGF-β1 synthesis in the kidney, with evidence for relief of translational repression in proximal tubular cells in the context of diabetic nephropathy. In this study, we have investigated the role of the TGF-β1 3'Untranslated Region (3'UTR). Two different 3'UTR lengths have been reported for TGF-β1, of 543 and 137 nucleotides. Absolute quantification showed that, while both UTR lengths were detectable in various human cell types and in a broad range of tissues, the short form predominated in the kidney and elsewhere. Expression of both forms was up-regulated following auto-induction by TGF-β1, but the short:long UTR ratio remained constant. Incorporation of the short UTR into a luciferase reporter vector significantly reduced reporter protein synthesis without major effect on RNA amount, suggesting post-transcriptional inhibition. In silico approaches identified multiple binding sites for miR-744 located in the proximal TGF-β1 3'UTR. A screen in RNA from human tissues showed widespread miR-744 expression. miR-744 transfection inhibited endogenous TGF-β1 synthesis, while direct targeting of TGF-β1 was shown in separate experiments, in which miR-744 decreased TGF-β1 3'UTR reporter activity. This work identifies miR-744-directed post-transcriptional regulation of TGF-β1 which, given the pleiotropic nature of cellular responses to TGF-β1, is potentially widely significant.