gebhart/patrepeval huggingface dataset:
Formation of BaSO4 Fibres with Morphological Complexity in Aqueous Polymer Solutions (2001)

BaSO4 fibres with morphological complexity were formed in aqueous solution with polyacrylate and partially monophosphonated poly(ethyleneoxide)-block-poly(methacrylic acid) additives by a simple precipitation reaction. For polyacrylate, formation of the fibrous deposits was strongly dependent on the level of supersaturation (S) and Ba2+:polymer molar ratio (R). At S = 60 to 80, and R = 3 to 14, highly anisotropic crystalline fibres consisting of bundles of BaSO4 nanofilaments were formed after several weeks, although the yield was low. The nanofilaments were also organized into cone-shaped aggregates at S = 80, and at lower R values these formed higher-order structures that consisted of multiple cone-on-cone assemblies with remarkable self-similarity. Increasing the supersaturation produced ovoid or cross-shaped dendritic particles for the range of molar ratios studied. In contrast, BaSO4 crystallisation in the presence of a partially phosphonated block copolymer gave a high yield of BaSO4 fibres up to 100 microm in length, and consisting of co-aligned bundles of 30 nm-diameter defect-free single-crystal nanofilaments with a uniform growth tip. A model for the defect-free growth of BaSO4 nanofilaments in aqueous polymer solutions based on amorphous precursor particles, vectorially directing forces and van der Waals attraction is proposed.
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2017)

NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD<sup>+)</sup> precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X). All subjects took their blinded supplement daily for eight weeks. Analysis of NAD<sup>+</sup> in whole blood demonstrated that NRPT significantly increases the concentration of NAD<sup>+</sup> in a dose-dependent manner. NAD<sup>+</sup> levels increased by approximately 40% in the NRPT 1X group and approximately 90% in the NRPT 2X group after 4 weeks as compared to placebo and baseline. Furthermore, this significant increase in NAD<sup>+</sup> levels was sustained throughout the entire 8-week trial. NAD<sup>+</sup> levels did not increase for the placebo group during the trial. No serious adverse events were reported in this study. This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD<sup>+</sup> levels sustainably.
The Serpin Protease-Nexin 1 Is Present in Rat Aortic Smooth Muscle Cells and Is Upregulated in <scp>l</scp> -NAME Hypertensive Rats (2003)

PN-1 may thus participate in the mechanisms that regulate thrombin activity in the vessel wall.
Enhanced temperature stability and exceptionally high electrical contrast of selenium substituted Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub> phase change materials (2017)

Compared to the pure telluride Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub>, Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>4</sub>Se (I) and Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>2</sub>Se<sub>3</sub> (II) thin films reveal an exceptionally large electrical contrast (increased by factor 100 for compound II) between the amorphous and crystalline phases.
Prediction of Reservoir Quality from Log-Core and Seismic Inversion Analysis with an Artificial Neural Network: A Case Study from the Sawan Gas Field, Pakistan (2020)

This paper presents a novel approach that aims to predict better reservoir quality regions from seismic inversion and spatial distribution of key reservoir properties from well logs. The reliable estimation of lithology and reservoir parameters at sparsely located wells in the Sawan gas field is still a considerable challenge. This is due to three main reasons: (a) the extreme heterogeneity in the depositional environments, (b) sand-shale intercalations, and (c) repetition of textural changes from fine to coarse sandstone and very coarse sandstone in the reservoir units. In this particular study, machine learning (ML) inversion algorithm was selected to predict the spatial variations of acoustic impedance (AI), porosity, and saturation. While trained in a supervised mode, the support vector machine (SVM) inversion algorithm performed effectively in identifying and mapping individual reservoir properties to delineate and quantify fluid-rich zones. Meanwhile, the Sequential Gaussian Simulation (SGS) and Gaussian Indicator Simulation (GIS) algorithms were employed to determine the spatial variability of lithofacies and porosity from well logs and core analyses data. The calibration of the detailed spatial variations from post-stack seismic inversion using SVM and wireline logs data indicated an appropriate agreement, i.e., variations in AI is related to the variations in reservoir facies and parameters. From the current study, it was concluded that in a highly heterogeneous reservoir, the integration of SVM and GIS algorithms is a reliable approach to achieve the best estimation of the spatial distribution of detailed reservoir characteristics. The results obtained in this study would also be helpful to minimize the uncertainty in drilling, production, and injection in the Sawan gas field of Pakistan as well as other reservoirs worldwide with similar geological settings.
Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon (2004)

In animal cells there are several regulatory complexes which interact with 20S proteasomes and give rise to functionally distinct proteasome complexes. gamma-Interferon upregulates three immuno beta catalytic subunits of the 20S proteasome and the PA28 regulator, and decreases the level of 26S proteasomes. It also decreases the level of phosphorylation of two proteasome alpha subunits, C8 (alpha7) and C9 (alpha3). In the present study we have investigated the role of phosphorylation of C8 by protein kinase CK2 in the formation and stability of 26S proteasomes. An epitope-tagged C8 subunit expressed in mammalian cells was efficiently incorporated into both 20S proteasomes and 26S proteasomes. Investigation of mutants of C8 at the two known CK2 phosphorylation sites demonstrated that these are the two phosphorylation sites of C8 in animal cells. Although phosphorylation of C8 was not absolutely essential for the formation of 26S proteasomes, it did have a substantial effect on their stability. Also, when cells were treated with gamma-interferon, there was a marked decrease in phosphorylation of C8, a decrease in the level of 26S proteasomes, and an increase in immunoproteasomes and PA28 complexes. These results suggest that the down-regulation of 26S proteasomes after gamma-interferon treatment results from the destabilization that occurs after dephosphorylation of the C8 subunit.
Distribution and pattern of expression of villin, a gastrointestinal-associated cytoskeletal protein, in human carcinomas: a study employing paraffin-embedded tissue. (1991)

Villin is a 95-kilodalton gastrointestinal-related cytoskeletal protein associated with axial microfilament bundles of brush border microvilli. We tested the hypothesis that expression of this protein was restricted to adenocarcinomas of gastrointestinal origin in a retrospective study of 203 human neoplasm that had been fixed in Carnoy's or methacarn fixative and embedded in paraffin. Villin expression was restricted to a subset of epithelial tumors, with no expression noted in any cases of sarcoma, melanoma, or lymphoma. Villin proved to be a very sensitive and relatively specific marker of gastrointestinal adenocarcinomas: all colonic, gastric, and pancreatic carcinomas were positive, and none of the breast or lung carcinomas were positive, with the single exception of a bronchioalveolar adenocarcinoma. However, a subset of nongastrointestinal adenocarcinomas, including some adenocarcinomas of ovary, endometrium, and kidney, were also positive. Nonetheless, at least three distinct patterns of villin expression were discerned, some of which were quite specific for individual tumor types. Thus, an apical or brush border pattern of villin expression was seen in virtually all gastrointestinal adenocarcinomas, as well as in the occasional villin-positive endometrial or ovarian adenocarcinomas. A membranous distribution of carcinomas, mimicked the patterns of the normal counterpart tissue, e.g., delineation of bile canalicular structures. Finally, no relationship was found between the presence, or pattern of expression, of villin and the state of tumor differentiation. It is concluded that antibodies to villin may play an important role in immunocytochemical analyses of poorly differentiated malignant tumors in appropriately fixed, paraffin-embedded tissue and in cases where the primary site is indeterminant from clinical history and histology.
The blood brain barrier and the role of cytokines in neuropsychiatry. (2009)

Cytokines have emerged in the past two decades as some of the most extensively studied peptide molecules contributing to the pathophysiology of many diseases. As a result of these translational efforts, discovery of drugs aimed at reducing damage caused by cytokines has been accomplished for some conditions. The characterization of the role of cytokines in the pathophysiology of neuropsychiatric disorders is still in its infancy. This article highlights the growing correlation of brain cytokine levels with corresponding psychiatric symptoms, known as cytokine-induced sickness behavior, comprising increased sleep, decreased appetite, decreased sexual drive, and overwhelming fatigue frequently combined with fever.
Study on Disaster Prevention Countermeasures and Examples for Local Governments in Consideration of Regional Characteristics (2018)

Many researchers have highlighted the necessity of disaster prevention countermeasures based on regional characteristics. However, in situations wherein disaster prevention measures are executed, often, no index (data) objectively indicates the risk of disaster considering regional characteristics. Therefore, disaster prevention measures are sometimes implemented without considering regional characteristics. As such, a way to extract and present disaster prevention countermeasures and examples that consider regional characteristics, including the risk of disaster are now needed. In the present study, we search for indices of the regional characteristics necessary to implement disaster prevention countermeasures and study a method to extract these countermeasures and examples based on the indices. In addition, the appropriateness of the method to extract the disaster prevention countermeasures and examples considering regional characteristics is verified through a questionnaire survey and interview.
Multicast-based loss inference with missing data (2002)

Network tomography using multicast probes enables inference of loss characteristics of internal network links from reports of end-to-end loss seen at multicast receivers. We develop estimators for internal loss rates when reports are not available on all probes or from all receivers. This problem is motivated by the use of unreliable transport protocols, such as reliable transport protocol, to transmit loss reports to a collector for inference. We use a maximum-likelihood (ML) approach in which we apply the expectation maximization (EM) algorithm to provide an approximating solution to the the ML estimator for the incomplete data problem. We present a concrete realization of the algorithm that can be applied to measured data. For classes of models, we establish identifiability of the probe and report loss parameters, and convergence of the EM sequence to the maximum-likelihood estimator (MLE). Numerical results suggest that these properties hold more generally. We derive convergence rates for the EM iterates, and the estimation error of the MLE. Finally, we evaluate the accuracy and convergence rate through extensive simulations.
Monolithic and multi-GigaHertz mode-locked semiconductor lasers: Constructions, experiments, models and applications (2000)

Progress in technology, theory and applications of high-frequency mode-locked diode lasers is reviewed. We present a systematic overview of a wealth of experimental and theoretical results and approaches reported recently in the field of physics, technology and applications of monolithic mode-locked laser diodes.
Fundamentals of Geoenvironmental Engineering: Understanding Soil, Water, and Pollutant Interaction and Transport (2017)

Fundamentals of Geoenvironmental Engineering: Understanding Soil, Water, and Pollutant Interaction and Transport examines soil-water-pollutant interaction, including physico-chemical processes that occur when soil is exposed to various contaminants. Soil characteristics relevant to remedial techniques are explored, providing foundations for the correct process selection. Built upon the authors' extensive experience in research and practice, the book updates and expands the content to include current processes and pollutants. The book discusses propagation of soil pollution and soil characteristics relevant to remedial techniques. Practicing geotechnical and environmental engineers can apply the theory and case studies in the book directly to current projects. The book first discusses the stages of economic development and their connections to the sustainability of the environment. Subsequent chapters cover waste and its management, soil systems, soil-water and soil-pollutant interactions, subsurface transport of pollutants, role of groundwater, nano-, micro- and biologic pollutants, soil characteristics that impact pollution diffusion, and potential remediation processes like mechanical, electric, magnetic, hydraulic and dielectric permittivity of soils. Presents a clear understanding of the propagation of pollutants in soilsIdentifies the physico-chemical processes in soilsCovers emerging pollutants (nano-, micro- and biologic contaminants)Features in-depth coverage of hydraulic, electrical, magnetic and dielectric permittivity characteristics of soils and their impact on remedial technologies
A polarization-diversity wavelength duplexer circuit in silicon-on-insulator photonic wires (2007)

We present a wavelength duplexer based on a compact arrayed waveguide grating (AWG) in silicon-on-insulator photonic wire waveguides. Polarization insensitive operation is achieved through a special polarization diversity approach in which we use 2-D grating fiber couplers as integrated polarization splitters. To mitigate the effects of process variations, we propagated both polarizations in opposite directions through the same AWG with a mere 600x350microm(2) footprint. This resulted in an on-chip insertion loss between -2.1dB and -6.9dB, crosstalk of -15dB, and only 0.66dB polarization dependent loss. This is the first demonstration of a functional polarization-diversity circuit implemented in SOI nanophotonic waveguides, including interfaces to single-mode fiber.
Effects of interleukin-8 on nonspecific resistance to infection in neutropenic and normal mice (1993)

The effect of treatment with interleukin-8 (IL-8), a neutrophil-activating cytokine, was investigated in normal and neutropenic mice infected with a lethal dose of Pseudomonas aeruginosa, Klebsiella pneumoniae, or Plasmodium berghei. Intraperitoneal (i.p.) IL-8 treatment was associated with accelerated death when IL-8 was administered shortly before i.p. infection with P. aeruginosa or shortly after i.p. infection with P. aeruginosa and K. pneumoniae. Histopathological analyses demonstrated a tendency to more severe organ lesions in IL-8-treated mice. Only nonneutropenic mice that received IL-8 shortly before the infectious challenge and at the site of infection were protected by IL-8. Whether IL-8 is protective of or detrimental to the survival of infection appeared to depend on the presence of bacteria at the injection site and on the presence of neutropenia. IL-8 may be an important participant in the cascade of interacting cytokines that is induced by the lethal infectious challenge.
Multidimensional Measure of Display Clutter and Pilot Performance for Advanced Head-up Display (2011)

Measures and models of display clutter are expected to be applicable to the evaluation of a range of display concepts.
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[<i>b</i>][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease (2017)

Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes. We previously reported potent quinoline-based PDE5 inhibitors (PDE5Is) for the treatment of Alzheimer's disease (AD). However, the low aqueous solubility rendered them undesirable drug candidates. Here we report a series of novel PDE5Is with two new scaffolds, 1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine and 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one. Among them, compound 6c, 2-acetyl-10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile, the most potent compound, has an excellent in vitro IC<sub>50</sub> (0.056 nM) and improved aqueous solubility as well as good efficacy in a mouse model of AD. Furthermore, we are proposing two plausible binding modes obtained through in silico docking, which provide insights into the structural basis of the activity of the two series of compounds reported herein.
Robust gain-scheduled control in web winding systems (2002)

The plant is a web transport system with winder and unwinder. Due to a wide-range variation of the radius and inertia of the rollers the system dynamics change considerably. Two different control strategies for web tension and linear transport velocity are presented. The first is an H/sub /spl infin// robust control strategy with varying gains based on a particularity of the plant. The second is an LPV control strategy with smooth scheduling of controllers synthesized for different operating points. The quadratic stability and the quadratic performance of the closed loop system are analyzed. The LPV control strategy gives better results on an experimental setup, for the rejection of the disturbances introduced by velocity variations.
Dynamic Background Segmentation for Remote Reference Image Updating within Motion Detection JPEG2000 (2006)

We present in this paper a new system based on Motion JPEG2000 intended for road surveillance application. The system uses a reference image and consists in 4 processing steps, namely initialization phase where the first reference image is built, reference estimation, motion segmentation (foreground extraction, ROI mask), and JPEG2000 coding. A first order recursive filter is used to build a reference image that corresponds to the background image. The obtained background is sent to the decoder once for all. The reference image at the coder side is estimated according to a Gaussian mixture model. The remote reference image is updated when specific conditions are met. The updating remote reference is triggered according to the states of mobile objects in the scene (no, few or lot of mobiles). The motion detection given by classical background subtraction technique is performed in order to extract a binary mask. The motion mask gives the region of interest of the system. The JPEG2000 image coded with a ROI option is sent towards the decoder. The decoder receives, decodes the image and builds the implicit binary ROI mask. Then, the decoder builds the displayed image using the reference image, the current image and the mask.
Audiogenic Seizures Susceptibility in Transgenic Mice with Fragile X Syndrome (2000)

This study demonstrates that an increased susceptibility to audiogenic seizures is present in fragile X knockout mice at all the ages tested. These results support the validity of this animal model also for epilepsy and seizures in the human fragile X syndrome.
Analysis of nonlinear relation for skin hemoglobin imaging (2001)

This paper discusses the accuracy of the optical determination of the oxygenated and deoxygenated hemoglobin content of human skin under the influence of a melanin layer for a multi-wavelengths imager. The relation between the nonlinear results by Monte Carlo simulation (MCS) and the modified Lambert Beer's law (MLB) is also clarified, emphasizing the importance of the absolute values of skin pigments and their influence on the mean path-length used in MLB. The fitting procedure of the MCS data to the actual skin spectra is shown to obtain the absolute values. It is also shown that once the proper mean path-lengths have been determined, MLB can be used fairly well within an accuracy of 80% compared with MCS. Images of oxygenated hemoglobin with a newly-developed fourwavelength camera are presented to demonstrate the advantages of a multiwavelength system.
A Manifold Learning Approach for Personalizing HRTFs from Anthropometric Features (2016)

We present a new anthropometry-based method to personalize head-related transfer functions (HRTFs) using manifold learning in both azimuth and elevation angles with a single nonlinear regression model. The core element of our approach is a domain-specific nonlinear dimensionality reduction technique, denominated Isomap, over the intraconic component of HRTFs resulting from a spectral decomposition. HRTF intraconic components encode the most important cues for HRTF individualization, leaving out subject-independent cues. First, we modify the graph construction procedure of Isomap to integrate relevant prior knowledge of spatial audio into a single manifold for all subjects by exploiting the existing correlations among HRTFs across individuals, directions, and ears. Then, with the aim of preserving the multifactor nature of HRTFs (i.e. subject, direction and frequency), we train a single artificial neural network to predict low-dimensional HRTFs from anthropometric features. Finally, we reconstruct the HRTF from its estimated low-dimensional version using a neighborhood-based reconstruction approach. Our findings show that introducing prior knowledge in Isomap's manifold is a powerful way to capture the underlying factors of spatial hearing. Our experiments show, with p-values less than 0.05, that our approach outperforms using, either a PCA linear reduction, or the full HTRF, in its intermediate stages.