gebhart/patrepeval huggingface dataset:
Inhibition of 12-O-Tetradecanoylphorbol-13-Acetate-Induced Epidermal Ornithine Decarboxylase Activity and Tumor Promotion by N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide (W-7) in Mouse Skin (1986)

N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice. Inhibitory effect of W-7 on TPA-caused ODC induction was also observed in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated skin and even after repetitive TPA treatment. TPA-induced skin tumor promotion was also suppressed by W-7. Meanwhile, W-7 showed only slight inhibitory effects on calcium-activated, phospholipid-dependent protein kinase (protein kinase C) activity of mouse epidermis stimulated either by Ca2+ or TPA in the presence of phosphatidylserine. Thus, it is unlikely that the anti-ODC-inducing and anti-tumor-promoting actions of W-7 are due to its inhibitory effect on protein kinase C. It may be possible that a calmodulin-mediating process is involved in the mechanism of epidermal ODC induction and tumor promotion caused by tumor promoters such as TPA and teleocidin.
Maturity and thermal evolution differences between two sets of Lower Palaeozoic shales and its significance for shale gas formation in south‐western Sichuan Basin, China (2021)

Abtract The Lower Cambrian Qiongzhusi shale and the Upper Ordovician–Lower Silurian Wufeng‐Longmaxi shale are major source rocks and important shale gas exploration targets in the Sichuan Basin. Cutting and core samples from two shale gas wells in south‐western Sichuan Basin have been selected for organic matter (OM) reflectance measurement and Raman spectra analysis with the aim to determine maturity. The results were incorporated for basin modelling to construct the thermal evolution of this area. Graptolite fragments and pyrobitumens are the dominant form of OM in Wufeng‐Longmaxi shale. A limited number of the OM as pyrobitumens and vitrinite‐like particles is presented in Qiongzhusi shale. According to the measured reflectance of OM in conjunction with the maturity calculated using Raman spectra, the equivalent vitrinite reflectance (EqVRo) values based on solid bitumen and graptolite is 2.53–2.81% for the Wufeng‐Longmaxi shale. The EqVRo value is 2.85–3.53% within 300 m depth intervals for the Qiongzhusi shale. A significant difference in oil generation occurred before the Late Permian between Qiongzhusi shale and Wufeng‐Longmaxi shale based on basin modelling and reassessment of previous published data. Compared with the Qiongzhusi shale, the Wufeng‐Longmaxi shale would have lower maturities before Late Permian and less hydrocarbon could be generated/expelled at that time, therefore, this shale remained with a large amount of oil, which could crack into gas. This difference had shown a favourable time relationship for generation and accumulation of shale gas in Wufeng‐Longmaxi shale.
A Hexameric Peptide Barrel as Building Block of Amyloid‐β Protofibrils (2014)

Abstract Oligomeric and protofibrillar aggregates formed by the amyloid‐β peptide (Aβ) are believed to be involved in the pathology of Alzheimer’s disease. Central to Alzheimer pathology is also the fact that the longer Aβ 42 peptide is more prone to aggregation than the more prevalent Aβ 40 . Detailed structural studies of Aβ oligomers and protofibrils have been impeded by aggregate heterogeneity and instability. We previously engineered a variant of Aβ that forms stable protofibrils and here we use solid‐state NMR spectroscopy and molecular modeling to derive a structural model of these. NMR data are consistent with packing of residues 16 to 42 of Aβ protomers into hexameric barrel‐like oligomers within the protofibril. The core of the oligomers consists of all residues of the central and C‐terminal hydrophobic regions of Aβ, and hairpin loops extend from the core. The model accounts for why Aβ 42 forms oligomers and protofibrils more easily than Aβ 40 .
Large-Scale Carbon Nanotube Synthesis (2008)

Carbon nanotubes (CNTs) are a form of crystalline carbon with extraordinary chemical, physical, electrical and mechanical properties, making them potentially valuable in a broad range of applications. These properties have resulted in an unprecedented level of interest in the development of techniques to manufacture CNTs, and consequently a raft of competing patents have been issued, with universities and commercial entities alike looking to obtain patent protection for their inventions. In this paper we review relevant aspects of international patent law, summarize CNT definitions and discuss patent irregularities, and discuss the implications of the widening gap between nanotechnology practice and the underlying patent law. This is followed by a review of the chemical vapour deposition technique of CNT synthesis, in particular using a fluidised bed, identified as the most promising method to date for the large-scale, low cost production of CNTs. We further examine the carbon nanotube patent space, focusing primarily on patents for CNTs produced via CVD and FBCVD techniques. This patent space is both convoluted and uncertain, and it appears likely that some form of litigation will ensue in future to ultimately determine intellectual property ownership in various regions. We also discuss the likely effect of this 'patent thicket' on the commercialisation of large-scale CNT synthesis processes.
Involvement of FMN and phenobarbital cytochrome P-450 in stimulating a one-electron reductive denitrosation of 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea catalyzed by NADPH-cytochrome P-450 reductase. (1983)

Purified hepatic NADPH-cytochrome P-450 reductase, which was reconstituted with dilauroylphosphatidylcholine, catalyzed a one-electron reductive denitrosation of 1-(2-[14C]-chloroethyl)-3-(cyclohexyl)-1-nitrosourea ([14C]CCNU) to give 1-(2-[14C]-chloroethyl)-3-(cyclohexyl)urea at the expense of NADPH. Ambient oxygen or anoxic conditions did not alter the rates of [14C]CCNU denitrosation catalyzed by NADPH-cytochrome P-450 reductase with NADPH. Electron equivalents for reduction could be supplied by NADPH or sodium dithionite. However, the turnover number with NADPH was slightly greater than with sodium dithionite. Enzymatic denitrosation with sodium dithionite or NADPH was observed in anaerobic incubation mixtures which contained NADPH-cytochrome P-450 reductase with or without cytochrome P-450 purified from livers of phenobarbital (PB)-treated rats; PB cytochrome P-450 alone did not support catalysis. PB cytochrome P-450 stimulated reductase activity at molar concentrations approximately equal to or less than NADPH-cytochrome P-450 reductase concentration, but PB cytochrome P-450 concentrations greater than NADPH-cytochrome P-450 reductase inhibited catalytic denitrosation. Cytochrome c, FMN, and riboflavin demonstrated different degrees of stimulation of NADPH-cytochrome P-450 reductase-dependent denitrosation. Of the flavins tested, FMN demonstrated greater stimulation than riboflavin and FAD had no observable effect. A 3-fold stimulation by FMN was not observed in the absence of NADPH-cytochrome P-450 reductase. These studies provided evidence which establish NADPH-cytochrome P-450 reductase rather than PB cytochrome P-450 as the enzyme in the hepatic endoplasmic reticulum responsible for CCNU reductive metabolism.
Battery Technology Handbook (2003)

Fundamentals and theory, running techniques, applications, outlook-traction-batteries, stationary batteries and charging methods: electrochemical energy storage, D. Berndt batteries for electrical powered trucks, H.A. Kiehne power supply conceptsfor driverless industrial trucks, P. Preuss batteries for electric road vehicles, H.A. Kiehne battery-powered traction - the user's point of view, W. Konig safety standards for stationary batteries and battery installations, H. Willmes batteries forstationary power supply, H. Franke the operation of batteries from the view of the user, U.-C. Stahl automobile - starterbatteries, G. Sassmannhausen and E. Nann high energy batteries, C.-H. Dustmann (W. Fischer) solarelectric power supply withbatteries, H.K. Kothe charging methods and techniques - general demand and directions for selection of chargers, E. Wehrle technical aspects of chargers and current transformers - methods for supervision, G. Will standards and regulations for batteriesand battery - plants, H.A. Kiehne. Portable batteries modern portable batteries, an overview and outlook, H.A. Kiehne guidelines for selection, dimensioning and use of portable batteries, H.A. Kiehne (W. Raudzsus). Maintenance-free lead batteries withimmobilized electrolyte, H. Tuphorn lithium batteries - the latest variant of portable electrical energy, W. Jacobi the disposal of portable batteries, J.L. Fricke, N. Knudsen history, H.A.Kiehne.
Negative vergence training and its effect on the divergence range and heterophoria size (2000)

This study aimed to investigate the extent to which negative vergence training can influence the divergence range and the associated heterophoria size. Forty ocularly healthy participants (11 males and 29 females) with an age range between 17-64 years (mean age=26.6 years; SD=12.1 years) were included in the study. The participants were randomly allocated into four groups (n=10/Gp). The first group was trained using the diploscope treatment only, the second group was trained using the cat-stereograms card with additional modifications applied to it, the third group was trained using a standard cat- stereograms card without any modifications. Participants in these groups underwent training for 5 minutes, 3 times a day for 2 weeks. Lastly the control group did not undergo any training. Results indicated that there was a significant change in the mean near heterophoria size post training in all groups. This significant change was attributed to chance occurrence and may not yield any clinical relevance. A close to significant interaction between the groups training the cat-stereograms card with modifications and the group training with the standard cat-stereograms card was also found, signifying a better treatment success with modifications applied to the standard cat-stereograms card. Single case analysis of three esophoric participants, pointed to a possible future study to examine the impact of treatment on this group. (author abstract)
Evaluating Public Policies with High Frequency Data: Evidence for Driving Restrictions in Mexico City Revisited (2010)

The evaluation of public policies is on the heart of the e cient management of public resources. As complex as it generally is, any reform should be assessed on its ability to achieve its preconceived goals. This research paper attempts to show the importance of the design of a public policy's empirical evaluation, considering the susceptibility that its conclusions might have to changes in the approach to the data. The work of Davis (2008), which nds that a driving restrictions program had no impact on air quality in Mexico City, is revisited showing that reasonable changes in the methodology used can dramatically alter its conclusions. Additionally, evidence is presented that shows the success of the restrictions program in reducing air pollution by 12 to 18% during the first months of its implementation followed by a gradual increase in pollutants concentration, consistent with more limited opportunities for adaptation to the policy in the short-run. Finally, an alternative and robust framework is proposed to carry out the policy evaluation con rming the reduction of pollution right after the program's implementation.
An intelligent solar powered battery buffered EV charging station with solar electricity forecasting and EV charging load projection functions (2014)

An intelligent energy management approach for a solar powered EV charging station with energy storage has been studied and demonstrated for a level 2 charger at the University of California-Davis West Village. The approach introduces solar PV electrical energy forecasting and EV charging demand projection to optimize the energy management of the charging station. The percentage of cloud cover is extracted from a weather forecast website for estimating the available PV electrical energy. A linear fit of the historical EV charging load from the same day of the week over the previous six weeks is employed for extracting the charging pattern of the workplace EV charging station. Both simulations and actual operation show that intelligent energy management for a charging station with a buffer battery can reduce impacts of the EV charging system on utility grids in terms of peak power demand and energy exchange, reduce grid system losses, and benefit the charging station owner through the Time-of-Use rate plans.
AlphaScreen-based homogeneous assay using a pair of 25-residue artificial proteins for high-throughput analysis of non-native IgG (2017)

Therapeutic IgG becomes unstable under various stresses in the manufacturing process. The resulting non-native IgG molecules tend to associate with each other and form aggregates. Because such aggregates not only decrease the pharmacological effect but also become a potential risk factor for immunogenicity, rapid analysis of aggregation is required for quality control of therapeutic IgG. In this study, we developed a homogeneous assay using AlphaScreen and AF.2A1. AF.2A1 is a 25-residue artificial protein that binds specifically to non-native IgG generated under chemical and physical stresses. This assay is performed in a short period of time. Our results show that AF.2A1-AlphaScreen may be used to evaluate the various types of IgG, as AF.2A1 recognizes the non-native structure in the constant region (Fc region) of IgG. The assay was effective for detection of non-native IgG, with particle size up to ca. 500 nm, generated under acid, heat, and stirring conditions. In addition, this technique is suitable for analyzing non-native IgG in CHO cell culture supernatant and mixed with large amounts of native IgG. These results indicate the potential of AF.2A1-AlphaScreen to be used as a high-throughput evaluation method for process monitoring as well as quality testing in the manufacturing of therapeutic IgG.
ChemInform Abstract: Intramolecular 1,3‐Dipolar Cycloaddition Chemistry (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Label-free imaging of Drosophila in vivo by coherent anti-Stokes Raman scattering and two-photon excitation autofluorescence microscopy (2011)

Drosophila is one of the most valuable model organisms for studying genetics and developmental biology. The fat body in Drosophila, which is analogous to the liver and adipose tissue in human, stores lipids that act as an energy source during its development. At the early stages of metamorphosis, the fat body remodeling occurs involving the dissociation of the fat body into individual fat cells. Here we introduce a combination of coherent anti-Stokes Raman scattering (CARS) and two-photon excitation autofluorescence (TPE-F) microscopy to achieve label-free imaging of Drosophila in vivo at larval and pupal stages. The strong CARS signal from lipids allows direct imaging of the larval fat body and pupal fat cells. In addition, the use of TPE-F microscopy allows the observation of other internal organs in the larva and autofluorescent globules in fat cells. During the dissociation of the fat body, the findings of the degradation of lipid droplets and an increase in autofluorescent globules indicate the consumption of lipids and the recruitment of proteins in fat cells. Through in vivo imaging and direct monitoring, CARS microscopy may help elucidate how metamorphosis is regulated and study the lipid metabolism in Drosophila.
Effective Delivery of Apomorphine in the Management of Parkinson Disease (2015)

The clinical utility of long-term oral levodopa therapy in Parkinson disease (PD) is often limited by the emergence of motor complications. Over time, many patients with PD experience regular and/or unpredictable "off" periods, despite taking optimized oral medication regimens, with a major negative impact on their ability to undertake routine activities of daily living and consequently on their overall quality of life. One established approach for treating patients experiencing off periods and controlling motor fluctuations refractory to conventional oral drug therapy is the subcutaneous administration of the dopaminergic agonist apomorphine. This article outlines how the pharmacokinetic properties of apomorphine underpin its efficacy for the treatment of PD and provides practical guidance for the 3 main approaches in which it is used: subcutaneous intermittent apomorphine injection as a "rescue" therapy for off states, subcutaneous continuous apomorphine infusion for PD patients with intractable motor fluctuations as an alternative to other dopaminergic treatment, and in the apomorphine response (or challenge) test for assessment of dopamine-induced motor response in patients thought to have PD, or in establishing the optimal tolerated dose of apomorphine in patients already known to have PD. Also discussed is the management of potential adverse events with subcutaneous administration of apomorphine, the majority of which are mild and easily managed in practice. The importance of a multidisciplinary PD team in the optimal management of PD patients is now recognized, in particular the role of the specialist PD nurse.
Posttraumatic Stress Disorder and Physical Illness: Results from Clinical and Epidemiologic Studies (2004)

Research indicates that exposure to traumatic stressors and psychological trauma is widespread. The association of such exposures with posttraumatic stress disorder (PTSD) and other mental health conditions is well known. However, epidemiologic research increasingly suggests that exposure to these events is related to increased health care utilization, adverse health outcomes, the onset of specific diseases, and premature death. To date, studies have linked traumatic stress exposures and PTSD to such conditions as cardiovascular disease, diabetes, gastrointestinal disease, fibromyalgia, chronic fatigue syndrome, musculoskeletal disorders, and other diseases. Evidence linking cardiovascular disease and exposure to psychological trauma is particularly strong and has been found consistently across different populations and stressor events. In addition, clinical studies have suggested the biological pathways through which stressor-induced diseases may be pathologically expressed. In particular, recent studies have implicated the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal-medullary (SAM) stress axes as key in this pathogenic process, although genetic and behavioral/psychological risk factors cannot be ruled out. Recent findings, indicating that victims of PTSD have higher circulating T-cell lymphocytes and lower cortisol levels, are intriguing and suggest that chronic sufferers of PTSD may be at risk for autoimmune diseases. To test this hypothesis, we assessed the association between chronic PTSD in a national sample of 2,490 Vietnam veterans and the prevalence of common autoimmune diseases, including rheumatoid arthritis, psoriasis, insulin-dependent diabetes, and thyroid disease. Our analyses suggest that chronic PTSD, particularly comorbid PTSD or complex PTSD, is associated with all of these conditions. In addition, veterans with comorbid PTSD were more likely to have clinically higher T-cell counts, hyperreactive immune responses on standardized delayed cutaneous hypersensitivity tests, clinically higher immunoglobulin-M levels, and clinically lower dehydroepiandrosterone levels. The latter clinical evidence confirms the presence of biological markers consistent with a broad range of inflammatory disorders, including both cardiovascular and autoimmune diseases.
Optical fiber polarizer based on highly birefringent single-mode fiber (1995)

An in-line fiber polarizer is proposed and demonstrated. The attenuation of a single-mode fiber experiencing an axial periodic perturbation shows peaks at certain wavelengths, resulting from the power coupling between the guided mode and the cladding modes. When the fiber has significant linear birefringence, each of these peaks is split into two peaks. The fiber thus exhibits polarization-selective attenuation characteristics. An example of such a polarizer is demonstrated based on a highly birefringent fiber with a beat length of 1.3 mm. A 25-dB polarization extinction ratio is obtained, with an attenuation of 1.3 dB at an operating wavelength of 1177 nm.
Peripheral nerve regeneration with conduits：use of vein tubes (2015)

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.
Hyperthermia alone in the treatment of recurrences of malignant tumors: Experience with 60 lesions (1990)

Localized hyperthermia alone has been used for the treatment of cancer recurrences in which previous conventional therapies have failed. Since 1983 and 1988, 57 patients with 60 lesions have been heated by means of a microwave and radiofrequency system. Treatment protocol provided 45 minutes of heating at the intratumor temperature of at least 42 degrees C, twice a week, for a total number of six, eight, or ten heating sessions. Invasive intratumor thermometry was performed for all lesions. Complete response (CR) was obtained in ten cases (16.6%) and partial response (PR) in 14 (23.4%). Higher rates of CR were observed in the chest wall (38.5%) compared with the head and neck area (11.4%), trunk (10%), and limbs (none). Adenocarcinoma was the most responsive histologic type (40%). Squamous cells carcinoma had 7.7% CR. The only case of undifferentiated carcinoma showed CR; there were none on five sarcomas. Long-term local control (24 months) was approximately 7%. The multivariate analysis showed the statistical significance of the histologic variety (adenocarcinoma versus others, P less than 0.0001). Side effects and complications of the treatment were minimal.
Synthesis of Open-Cage Ketolactam Derivatives of Fullerene C<sub>60</sub> Encapsulating a Hydrogen Molecule (2014)

A novel open-cage fullerene C60 derivative having a bis(hemiketal) moiety was synthesized by the reaction of C60-N-MEM-ketolactam (MEM: 2-methoxyethoxymethyl) with N-methylmorpholine N-oxide in the presence of water. The structure was clearly determined by single crystal X-ray analysis. Further enlargement of the opening was performed by treatment with trifluoroacetic anhydride to give the tetraketo derivative having a 15-membered ring opening. For H2-insertion into the cage, the derivative was exposed to a high pressure of H2. After the encapsulation, the opening size was reduced to the original one while keeping the hydrogen molecule inside the cage. This compound can be a possible precursor for endohedral azafullerenes encapsulating a hydrogen molecule.