gebhart/patrepeval huggingface dataset:
Dynamic superimposition of synthetic objects on rigid and simple-deformable real objects (2002)

A current challenge in augmented reality applications is the accurate superimposition of synthetic objects on real objects within the environment. This challenge is heightened when the real objects are in motion and/or are nonrigid. In this article, we present a robust method for realtime, optical superimposition of synthetic objects on dynamic rigid and simple-deformable real objects. Moreover, we illustrate this general method with the VRDA Tool, a medical education application related to the visualization of internal human knee joint anatomy on a real human knee.
Magnetic properties and read-write characteristics of multilayer films on a glass substrate (1988)

Magnetic properties in read-write characteristics of a magnetic medium deposited on a soda-lime silicate glass substrate by DC magnetron sputtering at 10 mTorr partial pressure were studied. Two CoNiCr alloy films (each 35 nm in thickness) separated by a chromium film (12.5 nm in thickness) were sputtered onto a chromium underlayer, and a carbon film was deposited on the top of the cobalt alloy film for surface protection. The coercivity and remanence-thickness product were controlled independently. Higher coercivity was obtained as the film thickness of the chromium underlayer increased; 1000 Oe and 1400 Oe of coercivity were attained at 75 nm and 350 nm of underlayer thickness, respectively, while the remanence-thickness product stayed constant at 0.05 G-cm. Read-write characteristics of this five-layer system (double magnetic layers) deposited on a 5-1/4-in glass substrate with 950 Oe of a coercivity showed little difference in its parametric values compared with a three-layer system (single magnetic layer).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reconstruction of 3-D horizons from 3-D seismic datasets (2005)

We propose a method for extracting automatically and simultaneously the quasi-horizontal surfaces in three-dimensional (3-D) seismic data. The proposed algorithm identifies connected sets of points which form surfaces in 3-D space. To improve reliability, this algorithm takes into consideration the relative positions of all horizons, and uses globally self-consistent connectivity criteria which respect the temporal order of horizon creation. The first stage of the algorithm consists of the preliminary estimation of the local direction of each horizon at each point of the 3-D space. The second stage consists of smoothing the signal along the detected layer structure to reduce noise. The last stage consists of the simultaneous building of all 3-D horizons. The output of the processing is a set of 3-D horizons represented by a series of triangulated surfaces.
BindingDB Entry 5076: Affinity and selectivity of PD156707, a novel nonpeptide endothelin antagonist, for human ET(A) and ET(B) receptors. (2012)

We have determined the affinity and selectivity of a new nonpeptide antagonist PD156707 (sodium 2-benzo(1,3ioxol-5-yl-4-(4-methoxy-pheny l)-4-oxo-3-(3,4,5-trime tho xybenzyl)-but-2-enoate) for human endothelin (ET)(A) and ET(B) receptors. In human coronary artery and saphenous vein the affinity of the ET(A) receptor for PD156707 was 0.15 +/- 0.06 nM and 0.5 +/- 0.13 nM, respectively. Competition experiments in human left ventricle and kidney revealed that PD156707 had 1,000- to 15,000-fold selectivity for the ET(A) receptor over the ET(B) receptor. This selectivity was confirmed autoradiographically. In human coronary artery, mammary artery and saphenous vein PD156707 (3-300 nM) potently antagonized the vasoconstrictor responses to ET-1. The pA2 values estimated from the Gaddum-Schild equation were 8.07 +/- 0.09, 8.45 +/- 0.11 and 8.70 +/- 0.13, respectively. The concentration-response curves to ET-1 were shifted to the right in parallel fashion, without reduction of the maximum response. However, the regression lines fitted to the resulting Schild data deviated significantly from one. PD156707 appeared to be a more effective antagonist at lower concentrations than at the higher ones. It is possible that PD156707, a sodium salt, was reverting to a less soluble form which results in underestimation of its potency. These data show that PD156707 is a potent and selective antagonist at human ET(A) receptors and will be useful in clarifying the role of the endothelin peptides in human cardiovascular disease.
A Single Dose, Three-Arm, Placebo-Controlled, Phase I Study of the Bradykinin B2 Receptor Antagonist Anatibant (LF16-0687Ms) in Patients with Severe Traumatic Brain Injury (2005)

Traumatic brain injury (TBI) mortality and morbidity remains a public health challenge. Because experimental studies support an important role of bradykinin (BK) in the neurological deterioration that follows TBI, a double-blind, randomized, placebo-controlled study of Anatibant (LF16- 0687Ms), a selective and potent antagonist of the BK B(2) receptor, was conducted in severe (Glasgow Coma Scale [GCS] < 8) TBI patients (n = 25) at six sites in the United States. At 8-12 h after injury (9.9 +/- 2.8 h), patients received a single subcutaneous injection of Anatibant (3.75 mg or 22.5 mg, n = 10 each) or placebo (n = 5). The primary objective was to investigate the pharmacokinetics of Anatibant; general safety, local tolerability, levels of the bradykinin metabolite BK1-5 in plasma and cerebrospinal fluid (CSF), intracranial pressure (ICP), and cerebral perfusion pressure were also assessed. We observed a dose-proportionality of the pharmacokinetics, Cmax, and AUC of Anatibant. V(d)/F, Cl/F, and t(1/2) were independent on the dose and protein binding was >97.7%. Anatibant, administered as single subcutaneous injections of 3.75 g and 22.5 mg, was well tolerated in severe TBI patients with no unexpected clinical adverse events or biological abnormalities observed. Interestingly, plasma and CSF levels of BK1-5 were significantly and markedly increased after trauma (e.g., 34,700 +/- 35,300 fmol/mL in plasma vs. 34.9 +/- 5.6 fmol/mL previously reported for normal volunteers), supporting the use of Anatibant as a treatment of secondary brain damage. To address this issue, a dose-response trial that would investigate the effects of Anatibant on the incidence of raised ICP and on functional outcome in severe TBI patients is needed.
<i>Clostridium difficile</i>in Long-Term–Care Facilities for the Elderly (2002)

Antimicrobial agents are among the most frequently prescribed medications in long-term-care facilities (LTCFs). Therefore, it is not surprising that Clostridium difficile colonization and C. difficile-associated diarrhea (CDAD) occur commonly in elderly LTCF residents. C. difficile has been identified as the most common cause of non-epidemic acute diarrheal illness in nursing homes, and outbreaks of CDAD in LTCFs have also been recognized. This position paper reviews the epidemiology and clinical features of CDAD in elderly residents of LTCFs and, using available evidence, provides recommendations for the management of C. difficile in this setting.
Differential Expression and Turnover of the Tomato Polyphenol Oxidase Gene Family during Vegetative and Reproductive Development (1997)

Polyphenol oxidases (PPOs) are encoded by a highly conserved, seven-member gene family clustered within a 165-kb locus on chromosome 8 of tomato (Lycopersicon esculentum). Using gene-specific probes capable of differentiating between PPO A/C, PPO B, PPO D, and PPO E/F, we examined the spatial and temporal expression of this gene family during vegetative and reproductive development. RNA blots and in situ hybridization using these probes showed that although PPO expression is primarily confined to early stages of development, the steady-state mRNA levels of these genes are subject to complex patterns of spatial and temporal regulation in vegetative and reproductive organs. Young tomato leaves and flowers possess the most abundant PPO transcripts. PPO B is the most abundant in young leaves, whereas in the inflorescence PPO B and E/F transcripts are dominant. Differential expression of PPOs is also observed in various trichome types. PPO A/C are specifically expressed in type I and type IV trichomes. In contrast, PPO D is only expressed in type VI trichomes. Type I, IV, and VI trichomes possess PPO E/F transcripts. Immunolocalization verified the translational activity of PPOs identified by in situ hybridization and suggested cell-type-specific, developmentally programmed PPO turnover. In addition, immunolocalization demonstrated the accumulation of PPO in specific idioblast cells of stems, leaves, and fruits.
Meeting report on the Alzheimer’s Drug Discovery Foundation 14th International Conference on Alzheimer’s Drug Discovery (2014)

The Alzheimer’s Drug Discovery Foundation’s 14th International Conference on Alzheimer’s Drug Discovery was held on 9 and 10 September in Jersey City, NJ, USA. This annual meeting highlights novel therapeutic approaches supported by the Alzheimer’s Drug Discovery Foundation in development for Alzheimer’s disease and related dementias.
REVIEWS OF BOOKS (1987)

Journal Article REVIEWS OF BOOKS Get access Beethoven's Critics: Aesthetic Dilemmas and Resolutions during the Composer's Lifetime. By Robin Wallace. pp. viii + 184. ( Cambridge University Press, 1986, £22.50.) KATHARINE ELLIS KATHARINE ELLIS Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 68, Issue 3, July 1987, Pages 293–294, https://doi.org/10.1093/ml/68.3.293 Published: 01 July 1987
Index of Suspicion (2013)

The reader is encouraged to write possible diagnoses for each case before turning to the discussion. We invite readers to contribute case presentations and discussions. Please inquire first by contacting Dr Deepak Kamat at DKamat@med.wayne.edu. 

A 5-week-old, healthy, full-term, female infant, delivered via uncomplicated cesarean section, presents to the emergency department with a gradual decrease of right arm movement during the last 5 days. Although initially calm and comfortable, she now keeps her arm at her side and cries when the parents try to move her arm over her head. She has no history of fever, trauma, swelling, rash, or recent upper respiratory tract illness. The mother’s prenatal laboratory study results, including screening for human immunodeficiency virus, syphilis, hepatitis B, and group B streptococci (at 36 weeks), are negative.

Physical examination reveals a well-appearing infant with normal vital signs, who keeps her right arm in a neutral position at her side. There is no swelling or erythema. She cries with palpation of the lateral aspect of her right upper arm and with flexion and abduction of the shoulder.

Results of her laboratory studies include the following: white blood cell (WBC) count, 13,800/μL (13.8 × 109/L) with 63% neutrophils, 27% lymphocytes, and 10% monocytes; hemoglobin, 10.2 g/dL (102 g/L); platelet count, 548 × 103/μL(548 × 109/L); erythrocyte sedimentation rate (ESR), 93 mm/h; and C-reactive protein (CRP), 6.4 mg/dL (64 mg/L). Shoulder radiography reveals a lytic lesion of the proximal right humerus (Fig 1). An additional imaging study and surgical procedure establish the diagnosis.



Figure 1. 
Shoulder radiograph showing a lytic lesion of the proximal humerus.



A previously healthy 5-year-old girl presents with severe fatigue, dysphagia, and swelling of the face and neck. Two weeks earlier she developed symptoms of upper respiratory tract infection, halitosis, and fever. …
Review of aircraft electric power systems and architectures (2014)

In recent years, the electrical power capacity is increasing rapidly in more electric aircraft (MEA), since the conventional mechanical, hydraulic and pneumatic energy systems are partly replaced by electrical power system. As a consequence, capacity and complexity of aircraft electric power systems (EPS) will increase dramatically and more advanced aircraft EPSs need to be developed. This paper gives a brief description of the constant frequency (CF) EPS, variable frequency (VF) EPS and advanced high voltage (HV) EPS. Power electronics in the three EPS is overviewed.
Effect of Ligand Structure on the Zinc-Catalyzed Henry Reaction. Asymmetric Syntheses of (−)-Denopamine and (−)-Arbutamine (2002)

[reaction: see text] Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the beta-receptor agonists (-)-denopamine and (-)-arbutamine.
Popular culture and politics in imperial Vienna (2019)

The origins of Vienna’s modern popular culture are to be found in the late eighteenth century. Culture as a commodity could provide a focus for workers’ leisure time as well as giving access to the privilege and power available to the educated. From the outset Social-Democratic cultural policy was caught between challenging the workers’ exclusion from high culture and steering them away from the temptations of passive consumption. Except in so far as popular participation in culture was the consequence of government educational and social policy, the governments of the late nineteenth century did not yet have cultural or arts policies as such. The culture of Vienna at the turn of the century was caught between a numbers of competing claims. The politicization of culture in the years between the wars was of a different order to the initiatives of the turn of the century but the foundations for those developments were laid before 1914.
Harmine stimulates proliferation of human neural progenitors (2016)

Harmine is the <i>β</i>-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell cultures containing human neural progenitor cells (hNPCs, 97% nestin-positive) derived from pluripotent stem cells. After 4 days of treatment, the pool of proliferating hNPCs increased by 71.5%. Harmine has been reported as a potent inhibitor of the dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A), which regulates cell proliferation and brain development. We tested the effect of analogs of harmine, an inhibitor of DYRK1A (INDY), and an irreversible selective inhibitor of monoamine oxidase (MAO) but not DYRK1A (pargyline). INDY but not pargyline induced proliferation of hNPCs similarly to harmine, suggesting that inhibition of DYRK1A is a possible mechanism to explain harmine effects upon the proliferation of hNPCs. Our findings show that harmine enhances proliferation of hNPCs and suggest that inhibition of DYRK1A may explain its effects upon proliferation <i>in vitro</i> and antidepressant effects <i>in vivo</i>.
ClickBAIT: Click-based Accelerated Incremental Training of Convolutional Neural Networks (2017)

Today's general-purpose deep convolutional neural networks (CNN) for image classification and object detection are trained offline on large static datasets. Some applications, however, will require training in real-time on live video streams with a human-in-the-loop. We refer to this class of problem as Time-ordered Online Training (ToOT) - these problems will require a consideration of not only the quantity of incoming training data, but the human effort required to tag and use it. In this paper, we define training benefit as a metric to measure the effectiveness of a sequence in using each user interaction. We demonstrate and evaluate a system tailored to performing ToOT in the field, capable of training an image classifier on a live video stream through minimal input from a human operator. We show that by exploiting the time-ordered nature of the video stream through optical flow-based object tracking, we can increase the effectiveness of human actions by about 8 times.
Control of Bacterial Wilt of Geranium with Phosphorous Acid (2006)

Various bactericides were screened for efficacy in protecting geranium plants (Pelargonium hortorum) from Ralstonia solanacearum infection. Many of these bactericides were found to slow the disease progress; however, they were not able to protect the plants from infection and subsequent death. Potassium salts of phosphorous acid were found to be effective in protecting plants from infection when applied as a drench. The active portion of the potassium salts was found to be phosphorous acid (H<sub>3</sub>PO<sub>3</sub>). Phosphorous acid was found to inhibit in vitro growth of R. solanacearum. It is thought to be protecting plants from infection by acting as a bacteriostatic compound in the soil. The plants, however, are not protected from aboveground infection on wounded surfaces. Phosphorous acid drenches were shown to protect geranium plants from infection by either race 1 or 3 of R. solanacearum. Other phosphorous-containing products commonly used in the industry, such as phosphorus pentoxide (P<sub>2</sub>O<sub>5</sub>) and phosphoric acid (H<sub>3</sub>PO<sub>4</sub>), were not able to protect plants from bacterial wilt infection.
Strained <i>p</i> -channel InGaSb/AlGaSb modulation-doped field-effect transistors (1992)

Strained In0.25Ga0.75Sb p-channel modulation-doped field-effect transistors with Al0.75Ga0.25Sb Be-doped barrier layers are demonstrated. The extrinsic normalised transconductances for 1.2μm gate length devices range from 33 to 51mS/mm at 300K and from 132 to 161mS/mm at 77K. At 300K, the devices operated in depletion mode with a threshold voltage of ̃0.3V, a normalised output conductance of less than 3mS/mm, and maximum drain current densities of ̃20mA/mm. The devices show promise for complementary heterojunction field-effect transistor logic applications.
X-ray wavefront sensing and optics metrology using a microfocus x-ray grating interferometer with electromagnetic phase stepping (2022)

A metrology method of x-ray optical elements based on an electromagnetic phase stepping x-ray grating interferometer with high slope accuracy is presented in this study. The device consists of an x-ray tube, a phase grating G1 for modulating the incoming wavefront, and an absorption grating G2 as a transmission mask to produce a broader moiré pattern for the x-ray camera. The focal spot of the microfocus x-ray source is shifted by a magnetic field from a solenoid coil. Electromagnetic phase stepping analysis is used to obtain a pixel-wise map of the wavefront phase distortion to replace the traditional precision mechanical scanning system, improving stability, speed, accuracy, and flexibility. The x-ray grating interferometer can be used as a feedback tool for evaluating the quality of optical elements and detecting defects caused by the x-ray beam or the x-ray optical elements in ordinary laboratories and mirror-processing centers without the need of scheduling synchrotron beam time.
Dual Regulation Role of <i>GH3.5</i> in Salicylic Acid and Auxin Signaling during Arabidopsis-<i>Pseudomonas syringae</i> Interaction (2007)

Salicylic acid (SA) plays a central role in plant disease resistance, and emerging evidence indicates that auxin, an essential plant hormone in regulating plant growth and development, is involved in plant disease susceptibility. GH3.5, a member of the GH3 family of early auxin-responsive genes in Arabidopsis (Arabidopsis thaliana), encodes a protein possessing in vitro adenylation activity on both indole-3-acetic acid (IAA) and SA. Here, we show that GH3.5 acts as a bifunctional modulator in both SA and auxin signaling during pathogen infection. Overexpression of the GH3.5 gene in an activation-tagged mutant gh3.5-1D led to elevated accumulation of SA and increased expression of PR-1 in local and systemic tissues in response to avirulent pathogens. In contrast, two T-DNA insertional mutations of GH3.5 partially compromised the systemic acquired resistance associated with diminished PR-1 expression in systemic tissues. The gh3.5-1D mutant also accumulated high levels of free IAA after pathogen infection and impaired different resistance-gene-mediated resistance, which was also observed in the GH3.6 activation-tagged mutant dfl1-D that impacted the auxin pathway, indicating an important role of GH3.5/GH3.6 in disease susceptibility. Furthermore, microarray analysis showed that the SA and auxin pathways were simultaneously augmented in gh3.5-1D after infection with an avirulent pathogen. The SA pathway was amplified by GH3.5 through inducing SA-responsive genes and basal defense components, whereas the auxin pathway was derepressed through up-regulating IAA biosynthesis and down-regulating auxin repressor genes. Taken together, our data reveal novel regulatory functions of GH3.5 in the plant-pathogen interaction.
GBM Volumetry using the 3D Slicer Medical Image Computing Platform (2013)

Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer - a free platform for biomedical research - provides an alternative to this manual slice-by-slice segmentation process, which is significantly faster and requires less user interaction. In this study, 4 physicians segmented GBMs in 10 patients, once using the competitive region-growing based GrowCut segmentation module of Slicer, and once purely by drawing boundaries completely manually on a slice-by-slice basis. Furthermore, we provide a variability analysis for three physicians for 12 GBMs. The time required for GrowCut segmentation was on an average 61% of the time required for a pure manual segmentation. A comparison of Slicer-based segmentation with manual slice-by-slice segmentation resulted in a Dice Similarity Coefficient of 88.43 ± 5.23% and a Hausdorff Distance of 2.32 ± 5.23 mm.
Stability of distributed power supply systems (1993)

A comprehensive stability analysis of a distributed power system (DPS) is performed. The possible performance degradation and stability problems caused by the loading effect of cascaded converters are analyzed. The effect of impedance overlap on the system and individual subsystems is examined. By applying the loop gain analysis technique, a forbidden region for the polar plot of the ratio of impedances at the interface between cascaded subsystems is determined. A method of transforming the forbidden region into a load impedance specification for a given source impedance is developed. The method guarantees system stability and minimal performance degradation of the DPS, while allowing impedance overlap at the interface.
Similar images compression based on DCT pyramid multi-level low frequency template (2012)

Medical imaging applications produce a huge amount of similar images. Instead of compressing each image individually, set redundancy compression (SRC) methods remove the inter image redundancy and reduce storage. However, in the previous SRC methods — -MMD, MMP and Centroid methods, the prediction templates for extracting set redundancy are not very efficient, especially when image sets are very large with several clusters. In this paper, inspired by face recognition techniques, a novel lossless SRC method is derived based onDCT pyramid multi-level low frequency template. The approximation subband is used as a prediction template for each image to calculate the residue. Intra prediction is also used to reduce the entropy of the residues. Experiments with 3 sets of MR brain images demonstrate the efficiency of our proposed algorithm in respect to bits/pixel (bpp).