gebhart/patrepeval huggingface dataset:
Enhancing Magnetic Immunity of STT-MRAM with Magnetic Shielding (2018)

We present the first magnetic shielding study including design, modeling, fabrication and characterization of package level magnetic shield for perpendicular spin-transfer torque magneto resistive random-access memory (STT-MRAM). Magnetic shielding improves the magnetic immunity of STT-MRAM against the applied external perpendicular magnetic field by three times. It improves the bit error rate by more than four orders at an applied external perpendicular magnetic field of 500 Oe and without ECC turned on. Modeled a keep out zone of 1mm for MTJ, corresponding to wire-bond window opening of 0.7mm.
A systolic architecture for discrete wavelet transforms (2002)

We present an integrated systolic architecture for computation of the one-dimensional discrete wavelet transform (DWT) of signals. This integrated architecture is useful for both decomposition (forward DWT) and reconstruction (inverse DWT) of signals. The architecture has been designed based on an efficient systolic algorithm suitable for high speed VLSI implementation. This integrated systolic architecture is very unique in the sense that the same architecture is used for forward DWT and inverse DWT by selecting some suitable control signals and this systolic architecture yields 100% utilization unlike many other existing architectures in the literature. The two-dimensional DWT architecture can easily be designed by extending this one-dimensional solution.
Diagnosis of cardiac allograft vasculopathy Challenges and opportunities (2016)

Cardiac allograft vasculopathy (CAV) is one of the most common long-term complications in patients following heart transplantation. Because of its irreversible nature, early detection is essential to impact progression. Thus, imaging techniques play a crucial role in the diagnosis and subsequent treatment. Major advancements in imaging and analysis are required to overcome the limitations of current techniques. Coronary angiography which is the standard method, presents low sensitivity in detection, especially at an early stage. Intravascular ultrasonography is a more reliable alternative but is limited to the epicardial vessels. Novel non-invasive techniques, such as stress echocardiography and nuclear imaging, have been introduced but not without limitations. Here, we review various imaging methods and associated analyses to improve diagnostic predictions. We discuss recent advances in the diagnosis of coronary artery disease and their potential translation in the diagnosis of CAV. Additionally, we present potential biomarkers that have been identified for CAV. Finally, we provide a discussion on microvessels with novel anticoagulant properties that are mostly identified in patients with severe CAV.
Influence of Nb/Al Composition on the Microstructure and Superconducting Properties of RHQT-processed Nb3Al Wire. (2003)

Nb/Al precursor wire with a composition of Nb-25at%Al is converted into a bcc supersaturated solid solution (Nb(Al)SS) through RHQ treatment, of which the maximum heating temperature is around 2,000°C. However, the solubility limit of the bcc phase is 21.5at%Al. Therefore, the solid solution phase does not exist in a state of equilibrium at 25at%Al. Why 25at%Al bcc Nb(Al)SS forms is not clear. Accordingly, we studied the high-temperature state of the solid solution phase at around 2,000°C. We have made four kinds of samples with different Al compositions, ranging from 22.6at% to 30.0at%, and subjected them to RHQ treatment at temperatures from 1,900°C to 2,400°C. We measured variations in the microstructure and superconducting properties at the maximum heating temperature for each composition. We found that the temperature range where only the solid solution phase forms decreases as Al concentration increase. This clearly indicates that the solid solution phase extends to at least 27at%Al.
Antineoplastic Agents. 509. Synthesis of Fluorcombstatin Phosphate and Related 3-Halostilbenes<sup>,1</sup> (2005)

The present SAR study of combretastatin A-3 (3a) focused on replacement of the 3-hydroxyl group by a series of halogens. That approach with Z-stilbenes resulted in greatly enhanced (>10-100-fold) cancer cell growth inhibition against a panel of human cancer cell lines and the murine P388 lymphocytic leukemia cell line. Synthesis of the 3-fluoro-Z-stilbene designated fluorcombstatin (11a) and its potassium 3'-O-phosphate derivative (16c) by the route 7 --> 8a --> 11a --> 14 --> 16c illustrates the general synthetic pathway. The 3'-O-phosphoric acid ester (15) of 3-bromo-Z-stilbene 13a was also converted to representative cation salts to evaluate the potential for improved aqueous solubility, and the potassium salt (16 mg/mL in water) proved most useful. The fluoro (11a), chloro (12a), and bromo (13a) halocombstatins were nearly equivalent to combretastatin A-4 (1a) as inhibitors of tubulin polymerization and of the binding of colchicine to tubulin. The tubulin binding in cell-free systems was also retained in human umbilical vein endothelial cells. All three halocombstatins retained the powerful human cancer cell line inhibitory activity of combretastatin A-4 (1a) and proved superior to combretastatin A-3 (3a). In addition, the halocombstatins targeted Gram-positive bacteria and Cryptococcus neoformans.
Anti-miRNA Oligonucleotide Therapy for Chondrosarcoma (2019)

Chondrosarcoma is a highly aggressive primary malignant bone tumor mostly occurring in adults. There are no effective systemic treatments, and patients with this disease have poor survival. miR-181a is an oncomiR that is overexpressed in high-grade chondrosarcoma and promotes tumor progression. Regulator of G-protein signaling 16 (RGS16) is a target of miR-181a. Inhibition of RGS16 expression by miR-181a enhances CXC chemokine receptor 4 signaling, which in turn increases MMP1 and VEGF expression, angiogenesis, and metastasis. Here, we report the results of systemic treatment with anti-miRNA oligonucleotides (AMO) directed against miR-181a utilizing a nanopiece delivery platform (NPs). NPs were combined with a molecular beacon or anti-miR-181a oligonucleotides and are shown to transfect chondrosarcoma cells <i>in vitro</i> and <i>in vivo</i> Intratumoral injection and systemic delivery had similar effects on miR-181a expression in nude mice bearing chondrosarcoma xenografts. Systemic delivery of NPs carrying anti-miR-181a also restored <i>RGS16</i> expression, decreased expression of VEGF and MMP1, MMP activity, and tumor volume by 32% at day 38, and prolonged survival from 23% to 45%. In conclusion, these data support that systemic delivery of AMO shows promise for chondrosarcoma treatment.
The Endothelial Cell Protein C Receptor (1996)

Expression of the endothelial cell protein C receptor (EPCR) gene in mammalian cells imparts the capacity to bind activated protein C (APC) or protein C. Immunochemical analysis of CCD41, apparently the murine homologue of EPCR, suggested centrosomal localization, raising questions about the location of the EPCR gene product and its role in protein C binding. In this study, we express a soluble form of EPCR, demonstrate EPCR expression on the cell surface, and direct binding between soluble EPCR and protein C/APC. Affinity purified polyclonal and a monoclonal antibody against EPCR bound to the cell surface of EPCR-transfected cells but not to control cells. A 49-kDa protein, a mass similar to soluble EPCR, was immunoprecipitated from the cell surface of endothelium and cells transfected with human EPCR but not from control cells. The FLAGtrade mark antibody and APC bound to cells expressing an EPCR construct containing the FLAGtrade mark epitope located in a putative extracellular domain, whereas an EPCR construct truncated just before the putative transmembrane domain produced only soluble EPCR antigen. Soluble EPCR inhibited APC binding to EPCR expressing cells in a concentration-dependent fashion, Kd (app) = 29 nM and bound to immobilized protein C in a Ca2+-dependent fashion. Thus, EPCR is a type 1 transmembrane protein that binds directly to APC.
ChemInform Abstract: THE SELECTIVE PRODUCTION OF C2‐C4‐OLEFINS FROM METHANOL (1983)

Abstract Die Verwendung von Zeolithen als Katalysatoren fur die Umwandlung von Methanol in lithylen und Prupylen enthaltende Cxasgennsehe wird beschrieben.
Joint source/channel coding using arithmetic codes (2001)

Reserving space fur a symbol that is not in the source alphabet has been shown to provide excellent error detection. In this paper, we show how to exploit this capability using two sequential decoder structures to provide powerful error correction capability. This joint source/channel coder design provides significant packet loss recovery with minimal rate overhead, and compares favorably with conventional schemes.
A New Energy Efficient Fluorescent Lamp Ballast (1980)

A solid-state controlled ballast is described that utilizes a custom integrated circuit to provide lamp current and power regulation. The ballast provides a total energy savings over the life of a lamp of 40 percent, the combined result of improved lamp power regulation, lower ballast losses, and part-of-night dimming.
A Dry Platform for Separation of Proteins from Biomass‐Containing Polysaccharides, Lignin, and Polyphenols (2015)

License to mill: Proteins were continuously extracted from polysaccharides, lignin, and polyphenol by combining ultrafine milling with electrostatic separation. Such a fractionation process does not involve any solvent, catalyst, or external source of heating. In addition, this dry process is compatible with downstream enzymatic reactions, thus opening an attractive route for producing valuable chemicals from biomass.
Transposition and transduction of plasmid DNA inStreptomyces spp. (1991)

To expand the application of molecular genetics to many different streptomycete species, we have been developing two potentially widely applicable methodologies: transposon mutagenesis and plasmid transduction. We constructed three transposons from the Streptomyces lividans insertion sequence IS493. Tn5096 and Tn5097 contain an apramycin resistance gene inserted in different orientations between the two open reading frames of IS493. These transposons transpose from different plasmids into many different sites in the Streptomyces griseofuscus chromosome and into its resident linear plasmids. Tn5099 contains a promoterless xylE gene and a hygromycin-resistance gene inserted in IS493 close to one end. Tn5099 transposes in S. griseofuscus giving operon fusions in some cases that drive expression of the xylE gene product, catechol deoxygenase, giving yellow colonies in the presence of catechol. We have also developed plasmid vectors that can be transduced into many streptomycete species by bacteriophage FP43. We describe the characterization of FP43 and mapping of several bacteriophage functions. The region of cloned FP43 DNA essential for plasmid transduction includes the origin for headful packaging.
Mobile multi-hop relay system using AMC for multicast broadcast service over mobile WiMAX (2008)

Mobile WiMAX based on IEEE802.16e standard supports various kinds of broadband data services such as VOD, VoIP, and MBS (multicast broadcast service). Unlike wired networks, however, wireless networks have limited bandwidth. MBS overcomes this problem using a shared downlink channel for efficiently supporting a number of users. However, its coverage and throughput are significantly affected by the operational condition. In this paper we propose to employ mobile multi-hop relay (MMR) along with an adaptive modulation and coding (AMC) scheme to increase the performance of MBS. The result of computer simulation with NS-2 shows that the throughput and transmission time are substantially improved by using the proposed approach compared to the existing MBS system.
Interactive physical design tuning (2010)

In the last decade, automated physical design tuning became a relevant area of research. The process of tuning a workload became more flexible but also more complex, and getting the best design upfront became difficult. We propose a paradigm shift for physical design tuning, in which sessions are highly interactive, allowing DBAs to quickly try different options, identify problems, and obtain physical designs in an agile manner.
Isolating the Role of the Node-Linker Bond in the Compression of UiO-66 Metal–Organic Frameworks (2020)

Understanding the mechanical properties of metal–organic frameworks (MOFs) is essential to the fundamental advancement and practical implementations of porous materials. Recent computational and experimental efforts have revealed correlations between mechanical properties and pore size, topology, and defect density. These results demonstrate the important role of the organic linker in the response of these materials to physical stresses. However, the impact of the coordination bond between the inorganic node and organic linker on the mechanical stability of MOFs has not been thoroughly studied. Here, we isolate the role of this node–linker coordination bond to systematically study the effect it plays in the compression of a series of isostructural MOFs, M-UiO-66 (M = Zr, Hf, or Ce). The bulk modulus (i.e., the resistance to compression under hydrostatic pressure) of each MOF is determined by in situ diamond anvil cell (DAC) powder X-ray diffraction measurements and density functional theory (DFT) simulations. These experiments reveal the distinctive behavior of Ce-UiO-66 in response to pressures under 1 GPa. In situ DAC Raman spectroscopy and DFT calculations support the observed differences in compressibility between Zr-UiO-66 and the Ce analogue. Monitoring changes in bond lengths as a function of pressure through DFT simulations provides a clear picture of those which shorten more drastically under pressure and those which resist compression. We hypothesize that the presence of ∼10% Ce3+ in the nodes of Ce-UiO-66 may contribute to the weakening of the node–linker coordination, manifesting in the distinct behavior under pressure. This study demonstrates that changes to the node–linker bond can have significant ramifications on the mechanical properties of MOFs.
A Study on the Application of Tuned Vibration Absorbers to Nominally Cyclic Structures (2019)

Abstract The vibration absorber or tuned mass damper is a well-known mechanism, where a small mass connected to a larger structure is used to redirect vibration energy and provide reduction in vibration amplitudes at desired locations and frequencies. While tuned vibration absorbers have been widely applied for damping of mechanical systems, the concept remains largely unexplored in the design of dampers for bladed disks. This paper investigates whether such a vibration absorption mechanism is feasible for such nominally cyclic symmetric structures which are characterized by double modes, high modal density, and sensitivity to uncertainties such as mistuning. The single-degree of freedom vibration absorber concept is extended for application to this complex modal space, and lumped mass models are used for analysis. Trends in effectiveness of a vibration absorption based damper are explored by studying sensitivities to various parameters such as stiffness and damping at various locations. Effects of mistuning across sectors and locations of damper attachment are also considered. The results of the study establish the feasibility of the vibration absorption mechanism for application in blisks, and encourage further exploration of the concept, possibly in conjunction with other well-established damping mechanisms such as friction.
Baseline-free quantitative absorption spectroscopy based on cepstral analysis (2019)

The accuracy of quantitative absorption spectroscopy depends on correctly distinguishing molecular absorption signatures in a measured transmission spectrum from the varying intensity or 'baseline' of the light source. Baseline correction becomes particularly difficult when the measurement involves complex, broadly absorbing molecules or non-ideal transmission effects such as etalons. We demonstrate a technique that eliminates the need to account for the laser intensity in absorption spectroscopy by converting the measured transmission spectrum of a gas sample to a modified form of the time-domain molecular free induction decay (m-FID) using a cepstral analysis approach developed for audio signal processing. Much of the m-FID signal is temporally separated from and independent of the source intensity, and this portion can be fit directly with a model to determine sample gas properties without correcting for the light source intensity. We validate the new approach in several complex absorption spectroscopy scenarios and discuss its limitations. The technique is applicable to spectra obtained with any absorption spectrometer and provides a fast and accurate approach for analyzing complex spectra.
Image formation of volume holographic microscopy using point spread functions (2010)

We present a theoretical formulation to quantify the imaging properties of volume holographic microscopy (VHM). Volume holograms are formed by exposure of a photosensitive recording material to the interference of two mutually coherent optical fields. Recently, it has been shown that a volume holographic pupil has spatial and spectral sectioning capability for fluorescent samples. Here, we analyze the point spread function (PSF) to assess the imaging behavior of the VHM with a point source and detector. The coherent PSF of the VHM is derived, and the results are compared with those from conventional microscopy, and confocal microscopy with point and slit apertures. According to our analysis, the PSF of the VHM can be controlled in the lateral direction by adjusting the parameters of the VH. Compared with confocal microscopes, the performance of the VHM is comparable or even potentially better, and the VHM is also able to achieve real-time and three-dimensional (3D) imaging due to its multiplexing ability.
Techno-economic Analysis of Biogas Conversion to Liquid Hydrocarbon Fuels through Production of Lean-Hydrogen Syngas (2022)

Large-scale biogas plants are a viable source of CH4 and CO2 to be converted efficiently into high-value products. Specifically, production of liquid hydrocarbons can enhance the availability of green fuels while achieving significant CO2 reductions on site. In this study, the production of liquid hydrocarbons is simulated by dry reforming of biogas into lean-hydrogen syngas, further converted in CO hydrogenation and oligomerization reactors. The process was modeled by using CHEMCAD based on published experimental results with the projected feed composition. A high molar feed ratio of CO2/CH4 (>1.7) was set for the reformer to minimize steam requirement while avoiding carbon formation and reaching an optimal H2 to CO molar ratio (0.7). Two options were techno-economically evaluated based on a biogas plant with a capacity of 5000 N m3/h that produces between 13.8 and 15.7 million liters per year of blending stock for transportation fuels. The economics of the process depends mainly on the cost and availability of the biogas. The minimum selling price of the liquid fuels is $1.47/L and $1.37/L for options 1 (once-through conversion of syngas to liquid fuels) and 2 (recycle of tail gas from oligomerization reactor), respectively, and can be significantly reduced in case the biogas throughput is increased to >20 000 N m3/h. Recycling of the tail gas (option 2) yielded higher productivity, resulting in higher carbon yield (77.9% on the basis of methane) and energy efficiency (67.1%). The economic viability of the process can be improved by implementing CO2 tax or other incentives to reduce capital investment. It provides a potential route for efficient conversion of biogas into liquid hydrocarbons to meet the increased demand for renewable fuels as blending stock in the transportation sector while improving the sustainability of the plant.
Enzymatic Generation of Highly Anticoagulant Bovine Intestinal Heparin (2017)

Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1, -3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.
Passive and active characterization of hybrid glass substrates for telecommunication applications (2002)

Phosphate glasses have become increasingly popular for planar waveguide devices owing in part to the development of a number of different commercial compositions with a wide range of optical, physical, chemical and laser properties. In addition, the recent development of low temperature bonding technology has made possible the fabrication of structures involving multiple glasses prepared as a single hybrid substrate. Combined, these new materials and technologies make possible the creation of devices with increasing integration and complexity. Here, we present passive characterization data collected on glass joints prepared with the low temperature bonding technology and active performance data of a hybrid DBR laser where the surface relief grating has been fabricated in the passive glass region of a hybrid substrate.
One-Pot Biocatalytic Transformation of Adipic Acid to 6-Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases (2019)

Production of platform chemicals from renewable feedstocks is becoming increasingly important due to concerns on environmental contamination, climate change, and depletion of fossil fuels. Adipic acid (AA), 6-aminocaproic acid (6-ACA) and 1,6-hexamethylenediamine (HMD) are key precursors for nylon synthesis, which are currently produced primarily from petroleum-based feedstocks. In recent years, the biosynthesis of adipic acid from renewable feedstocks has been demonstrated using both bacterial and yeast cells. Here we report the biocatalytic conversion/transformation of AA to 6-ACA and HMD by carboxylic acid reductases (CARs) and transaminases (TAs), which involves two rounds (cascades) of reduction/amination reactions (AA → 6-ACA → HMD). Using purified wild type CARs and TAs supplemented with cofactor regenerating systems for ATP, NADPH, and amine donor, we established a one-pot enzyme cascade catalyzing up to 95% conversion of AA to 6-ACA. To increase the cascade activity for the transformation of 6-ACA to HMD, we determined the crystal structure of the CAR substrate-binding domain in complex with AMP and succinate and engineered three mutant CARs with enhanced activity against 6-ACA. In combination with TAs, the CAR L342E protein showed 50-75% conversion of 6-ACA to HMD. For the transformation of AA to HMD (via 6-ACA), the wild type CAR was combined with the L342E variant and two different TAs resulting in up to 30% conversion to HMD and 70% to 6-ACA. Our results highlight the suitability of CARs and TAs for several rounds of reduction/amination reactions in one-pot cascade systems and their potential for the biobased synthesis of terminal amines.