gebhart/patrepeval huggingface dataset:
A CoAP-Based Network Access Authentication Service for Low-Power Wide Area Networks: LO-CoAP-EAP (2017)

The Internet-of-Things (IoT) landscape is expanding with new radio technologies. In addition to the Low-Rate Wireless Personal Area Network (LR-WPAN), the recent set of technologies conforming the so-called Low-Power Wide Area Networks (LP-WAN) offers long-range communications, allowing one to send small pieces of information at a reduced energy cost, which promotes the creation of new IoT applications and services. However, LP-WAN technologies pose new challenges since they have strong limitations in the available bandwidth. In general, a first step prior to a smart object being able to gain access to the network is the process of network access authentication. It involves authentication, authorization and key management operations. This process is of vital importance for operators to control network resources. However, proposals for managing network access authentication in LP-WAN are tailored to the specifics of each technology, which could introduce interoperability problems in the future. In this sense, little effort has been put so far into providing a wireless-independent solution for network access authentication in the area of LP-WAN. To fill this gap, we propose a service named Low-Overhead CoAP-EAP (LO-CoAP-EAP), which is based on previous work designed for LR-WPAN. LO-CoAP-EAP integrates the use of Authentication, Authorization and Accounting (AAA) infrastructures and the Extensible Authentication Protocol (EAP) protocol. For this integration, we use the Constrained Application Protocol (CoAP) to design a network authentication service independent of the type of LP-WAN technology. LO-CoAP-EAP represents a trade-off between flexibility, wireless technology independence, scalability and performance in LP-WAN.
Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy (2007)

Progesterone-antagonist long-term therapy reduces [corrected] Pmp22 overexpression to a degree at which the axonal support function of Schwann cells is better maintained than myelination. This suggests that axonal loss in CMT1A is not caused by demyelination, but rather by a Schwann cell defect that has been partially uncoupled by anti-progesterone treatment. Pmp22 expression analysis in skin may provide a prognostic marker for disease severity and for monitoring future clinical trials.
Autoencoder and Its Various Variants (2018)

The concept of autoencoder was originally proposed by LeCun in 1987, early works on autoencoder were used for dimensionality reduction or feature learning. Recently, with the popularity of deep learning research, autoencoder has been brought to the forefront of generative modeling. Many variants of autoencoder have been proposed by different researchers and have been successfully applied in many fields, such as computer vision, speech recognition and natural language processing. In this paper, we present a comprehensive survey on autoencoder and its various variants. Furthermore, we also present the lineage of the surveyed autoencoders. This paper can provide researchers engaged in related works with very valuable help.
Negative Feedback Regulation of HIV-1 by Gene Editing Strategy (2016)

The CRISPR/Cas9 gene editing method is comprised of the guide RNA (gRNA) to target a specific DNA sequence for cleavage and the Cas9 endonuclease for introducing breaks in the double-stranded DNA identified by the gRNA. Co-expression of both a multiplex of HIV-1-specific gRNAs and Cas9 in cells results in the modification and/or excision of the segment of viral DNA, leading to replication-defective virus. In this study, we have personalized the activity of CRISPR/Cas9 by placing the gene encoding Cas9 under the control of a minimal promoter of HIV-1 that is activated by the HIV-1 Tat protein. We demonstrate that functional activation of CRISPR/Cas9 by Tat during the course of viral infection excises the designated segment of the integrated viral DNA and consequently suppresses viral expression. This strategy was also used in a latently infected CD4+ T-cell model after treatment with a variety of HIV-1 stimulating agents including PMA and TSA. Controlled expression of Cas9 by Tat offers a new strategy for safe implementation of the Cas9 technology for ablation of HIV-1 at a very early stage of HIV-1 replication during the course of the acute phase of infection and the reactivation of silent proviral DNA in latently infected cells.
Data on docking of phytoconstituents of Actinidia deliciosa on dengue viral targets (2019)

Major Phytoconstituents of <i>Actinidia deliciosa</i> were explored for their anti-viral potential against dengue virus (DENV). The docking of these phytoconstituents was performed on 7 viral targets- 4 DENV non structural protein (NS5-SAM binding domain, NS5 RdRp domain, NS3 helicase & NS2B-NS3 protease) and 3 DENV structural proteins (Envelope protein-β-OD domain, stem domain & Domain III). The analysis was done on the basis of binding affinity, type of interactions (bond type and distance) and interaction with amino acids significant in viral replication. The top 5 phytoconstituents with best docking score have been reported.
Extrapolation range measurements for determining antenna gain and polarization (1987)

The extrapolation range measurement technique for determining the power gain and polarization of antennas at reduced range dis- tances is described.
A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours (2018)

The safety profile of SAR405838 and pimasertib combined was consistent with the safety profiles of both drugs. Preliminary antitumour activity was observed.
Parameter and Return-value Analysis of Binary Executables (2007)

The recovery of parameter and return-value plays an important role in decompilation, reverse engineering, binary translation and software maintenance etc. Furthermore, related approaches are very useful to inter- procedural analyzing and slicing of binary executable. However, the operations on parameters and return- values always appear obscure after the optimizing phases of a compiler, which will make the recovery hard to realize. In this paper, we present a flow-insensitive but context-sensitive algorithm based on data dependence analysis to get back parameters and return- values. In addition, we discuss our experimental results obtained by applying our techniques to a static binary translation framework. Evidence shows that our method performs well in analyzing the parameters and return-values of executables. We use an IA-64 executable for demonstration, but our techniques are not limited to any particular architecture.
On the effect of swarm collective behavior on human perception: Towards brain-swarm interfaces (2015)

Swarms of autonomous robots consist of a large number of simple and inexpensive units that use local communication and sensing in order to achieve a common goal. They provide improved robustness and efficiency characteristics over single agent solutions due to their interchangeability and inherent redundancy. Human-Swarm Interaction (HSI) is a relatively new field that has captured the attention of many researchers over the last decade. Efforts have mainly focused on the design of human-swarm control interfaces, neglecting significant aspects like the human perception of the swarm behavior. In this work, we attempt to address this issue by examining the perception and representation of collective behaviors of swarms at the brain level of human supervisors. More specifically, the effect of swarm cohesion on the ElectroEncephaloGraphic (EEG) activity of the human supervisor is investigated. We show that brain activity is correlated to swarm cohesion levels, which refers to spreading in the motion of the swarm agents. Moreover, we show that as the cohesion of the swarm becomes lower, the subjects are less able to discern changes in the direction of its motion. This work provides the first evidence of representation of swarm collective behaviors at the brain level, which can lead to the design of a new generation of brain-swarm control and perception interfaces.
Multicolor IR emissive pixels (2007)

We have evaluated several methods for generating multi-color emission for IR scene projector applications. The baseline requirements we employed were the ability to simulate color temperatures in the range 300-3000 K, minimum radiance levels consistent with existing IR sensor requirements, 1000 Hz frame rates and manufacturability. The analysis led us to down select two independent approaches that are capable of meeting HWIL multicolor requirements. We describe and discuss each of the approaches, their expected performance as well as their limitations.
Patch Antenna Using Synthesized Polyimide for RFID Sensing (2006)

A new type of component, the patch antenna with the relative humidity sensing function using a modified polyimide is proposed for RFID. The proposed structure can be applied for RFID sensor tag as a physically and functionally combined antenna with the RH sensor. For high sensitivity, a polyimide film was synthesized from aromatic monomers where no hydrophobic element is included. The fabricated patch antenna with RH sensing function was characterized in view point of sensitivity. Furthermore, to enhance the resolution of the sensing function, the patch antenna was designed to have a narrower bandwidth by meandering structure. From the measured results, the sensitivity of the proposed structure was -108 kHz/%RH under 25%RH ~90%RH. This means that the proposed component provides the humidity sensing function as well as the radiation. Therefore, it is apparent that the proposed RH sensing antenna using a modified polyimide can be applicable and useful for the implementation of the compact RFID sensor tag
Road Vehicle Alert System Using IOT (2017)

The consequence of road accidents that involves a motorcycle is far more fatal for the rider than the other drivers. Yet, there has not been an effective vehicle alert system that can eliminate these avoidable motorcycle accidents caused by other drivers where they fail to notice the motorcycles. One of the major flaws with the existing vehicle alert systems is that it should not treat motorcycles as same as other vehicles as they take much longer time to brake than a cars do. Therefore, this project aimed to find an effective method to identify motorcycles and alert the other drivers when motorcyclists are around them in 20-meter radius. After extensive literature review, the best method to solve the problem is to use road side infrastructure based Internet of Things (IOT) that divides the network into a set of clusters. In this method to identify a vehicle, it is identifying the driver and the rider from their smartphone application that beacons custom, unique Media Access Control (MAC) addresses via Bluetooth or Wi-Fi to the IOT probes. The probe differentiates the users, registers them when they arrive into the network, alerts the driver about motorcycles around them and removes them from the database when they move to other cluster. The whole scenario is simulated using the OMNET++ simulator and INET framework to demonstrate how the methodology works. If the concept is implemented in real-life, many valuable lives of motorists will be much safer on the road.
Ex Vivo Technical Skills Training Transfers to the Operating Room and Enhances Cognitive Learning (2011)

Technical skills training using a low fidelity synthetic simulator resulted in improved technical performance in the operating room, and enhanced the ability of residents to attend to cognitive components of surgical expertise.
Enhanced transmission characteristics of on-chip interconnects with orthogonal gridded shield (2001)

On-chip interconnects over an orthogonal grid of grounded shielding lines on the silicon substrate are characterized by full-wave electromagnetic simulation. The analysis is based on a unit cell of the periodic shielded interconnect structure. It is demonstrated that the shielding structure may help to significantly enhance the transmission characteristics of on-chip interconnects particularly in analog and mixed-signal integrated circuits with bulk substrate resistivity on the order of 10 /spl Omega/-cm. Simulation results for the extracted R, L, G, C transmission line parameters show a significant decrease in the frequency-dependence of the distributed shunt capacitance as well as decrease in shunt conductance with the shielding structure present, while the series inductance and series resistance parameters are nearly unaffected. An extension of the equivalent circuit model for the shunt admittance of unshielded on-chip interconnects to include the effects of shielding is also presented.
N-3 Polyunsaturated Fatty Acids and Bone Metabolism (2000)

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), n-3 polyunsaturated fatty acid (n-3PUFA), have been shown to have beneficial effects on what? The beneficial effects of n-3PUFA, especially EPA on bone metabolism in vitro and in vivo were examined in this study.Osteoblasts are bone forming cells, that produce prostaglandin E2, an endogenous potent bone resorbing factor. To clarify the effects of EPA on bone metabolism, the effects of EPA on MC3T3-E1 cells, osteoblast-like cells were studied. The addition of MC3T3-E1 cells to EPA, but not DHA, caused increased calcium accumulation and Von-Kossa staining. In vivo experiments, the effect of EPA on strength of the femur in ovariectomized and low calcium/vitamin D3 fed rats were studied. EPA abolished the effects of ovariectomy with consequent recovery of the bone strength.Preliminary epidemiology studies indicate EPA ingestion possibly useful for preventing loss of bone weight and strength with aging. These findings and epidemiological studies, demonstrate EPA and marine oil to possibly have beneficial effects for preventing and improving age-related osteoporosis
Sequence specific visual detection of LAMP reactions by addition of cationic polymers (2006)

The presence or absence of minute amount of nucleic acid templates could be detected in a simple manner through visual assessment for the color of the LAMP amplicon-PEI complex precipitate. We conclude that this detection method may facilitate development of small and simple g-POCT device.
Vaccine therapy for renal cell carcinoma. (2003)

Several potential vaccines have been evaluated for the treatment of patients with renal cell carcinoma (RCC). They include dendritic cells pulsed with tumor lysate, a dendritic cell-tumor cell hybrid, irradiated tumor cells admixed with adjuvants, and a heat shock protein-peptide complex. Promising results have been obtained in several early clinical trials, but issues of tumor immunosuppression and lack of identified tumor-associated antigens must be addressed before vaccine therapy can be applied successfully in advanced RCC. In this patient population, vaccine therapy will likely be required in combination with other forms of immunotherapy, such as interleukin-2 and thalidomide. In contrast, vaccine therapy alone may be sufficient for high-risk patients in the adjuvant setting.
Throughput-Delay Performance of Half-Duplex Hybrid-ARQ Relay Channels (2008)

The throughput-delay performance of a half-duplex relay channel with hybrid-automatic retransmission request (HARQ) is analyzed in this paper. The protocol uses a form of incremental redundancy HARQ transmission with assistance from the relay via space-time coding if the relay decodes the message before the destination. The packet delay constraint is represented by L, the maximum number of HARQ rounds. An outage is declared if the packet is unsuccessful after L HARQ rounds. A delay-limited throughput is defined in this paper to explicitly account for finite delay constraints and associated non-zero packet outage probabilities. For small outage probabilities, this delay-limited throughput is greater than the conventional long-term average throughput. An exact expression is obtained for the outage probability to compare the throughput-delay performance of this half-duplex relay protocol with direct transmission. The delay-limited throughput of the relay channel is significantly larger than that of direct transmission for a wide range of signal-to-noise ratios (SNRs), target outage probabilities, delay constraints and relay positions.
Multiplexed single-cell proteomics using SCoPE2 (2021)

Abstract Many biological systems are composed of diverse single cells. This diversity necessitates functional and molecular single-cell analysis. Single-cell protein analysis has long relied on affinity reagents, but emerging mass-spectrometry methods (either label-free or multiplexed) have enabled quantifying over 1,000 proteins per cell while simultaneously increasing the specificity of protein quantification. Isobaric carrier based multiplexed single-cell proteomics is a scalable, reliable, and cost-effective method that can be fully automated and implemented on widely available equipment. It uses inexpensive reagents and is applicable to any sample that can be processed to a single-cell suspension. Here we describe an automated Single Cell ProtEomics (SCoPE2) workflow that allows analyzing about 200 single cells per 24 hours using only standard commercial equipment. We emphasize experimental steps and benchmarks required for achieving quantitative protein analysis. SCoPE2 Protocol
On the speedup required for a multicast parallel packet switch (2001)

A parallel packet switch (PPS) is a switch in which the memories run slower than the line rate. Arriving packets are load-balanced packet-by-packet over multiple lower speed center stage packet switches. It is known that, for unicast traffic, a PPS can precisely emulate a FCFS output-queued (OQ) switch with a speedup of two and an OQ switch with delay guarantees with a speedup of three. In this paper we ask: is it possible for a PPS to emulate the behavior of an OQ multicast switch? The main result is that for multicast traffic an N-port PPS can precisely emulate a FIFO OQ switch with a speedup of S>2/spl radic/N+1, and a switch that provides delay guarantees with a speedup of S>2/spl radic/(2N)+2.
THE EFFECT OF DIETARY REGIMEN EDUCATION ON THE LABORATORY VARIABLES AND INTERDIALYTIC WEIGHT GAIN IN HEMODIALYTIC PATIENTS (2006)

چکیده: زمینه و هدف: تغذیه یک فاکتور مهم در درمان بیماران مبتلا به بیماری مزمن کلیوی می باشد، به طوری که رژیم غذایی نامناسب باعث کاهش کیفیت زندگی و افزایش مشکلات و ناخوشی و مرگ و میر در این بیماران می شود. این پژوهش با هدف بررسی تأثیر آموزش رژیم غذایی بر شاخص های آزمایشگاهی و اضافه وزن بین دو جلسه دیالیز در بیماران تحت درمان با همودیالیز نگه دارنده انجام شد. روش بررسی: یک مطالعه قبل و بعد که در یک گروه به صورت پیش آزمون - پس آزمون در بیمارستان های آموزشی منتخب دانشگاه های علوم پزشکی تهران و ایران انجام گرفت. 32 بیمار تحت درمان با همودیالیز نگه دارنده بصورت غیر تصادفی و مبتنی بر هدف انتخاب گردیدند و با استفاده از پرسشنامه تعیین نیازهای آموزشی مورد بررسی قرار گرفتند. شاخص های آزمایشگاهی به صورت میانگین دو ماهه قبل از آموزش و اضافه وزن بین دو جلسه دیالیز در 4 نوبت در طی دو هفته قبل از آموزش اندازه گیری شد. سپس یک برنامه آموزشی بر اساس مشکلات تعیین شده و الگوی خود مراقبتی اورم تدوین و در طی چهار جلسه 20 دقیقه ای در روزهایی که بیماران دیالیز نمی شدند، به صورت پرسش و پاسخ بین بیماران و آموزش دهنده با کمک وسایل کمک آموزشی (اورهد و پاورپوینت) ارائه گردید. بعد از پایان آموزش، شاخص های آزمایشگاهی به صورت میانگین دو ماهه بعد از آموزش و اضافه وزن بیماران در 4 نوبت به فاصله دو هفته بعد از آموزش (هفته های سوم و پنجم) اندازه گیری و با استفاده از آزمون t زوجی تجزیه و تحلیل شدند. یافته ها: نتایج نشان دهنده کاهش قابل توجهی در میزان اوره (001/0p
Power supply current detectability of SRAM defects (2002)

We investigate correlations between SRAM cell defects and power supply current including I/sub DDQ/ (peak value of quiescent power supply current) and i/sub DDT/ (transient power supply current). Our results show that the power supply current can be used to detect cell shorts, cell opens, and disturb-type pattern sensitivity. We also investigate the effect of total current leakage in the power supply, which is proportional to SRAM size, on the power supply current detectability of SRAM cell defects. We present limits (obtained from simulation) on current detectability of SRAM cell defects as a function of normal power supply current leakage.
Studies on the Cytophilic Properties of Human β<sub>2</sub>‐Microglobulin (1979)

The mechanism by which exogenously added beta2m binds to lymphoid cells has been explored. In the mouse it has been shown that beta2m remains associated with plasma membrane macromolecules following solubilization with NP-40 and that approximately 25-30% of the binding could be accounted for by binding to H-2 antigens. No binding to mouse immunoglobulin or Ia antigens could be detected. The sites for binding of the remainder of the cell-bound beta2m were not determined. Whereas normal human lymphocytes showed little or no capacity to bind exogenously added beta2m, it was found that phytohaemagglutinin (PHA)-stimulated cells could bind beta2m. This binding occurred optimally 2 days after PHA stimulation. Approximately half of the binding could be accounted for by binding to HLA antigens. The possible significance of these findings with respect to cellular interactions involving major histocompatibility complex gene products in the immune response is discussed.
Cyclodextrins but not Compactin Inhibit the Lateral Diffusion of Membrane Proteins Independent of Cholesterol (2006)

Cholesterol and glycosphingolipid-enriched membrane domains, termed lipid rafts, were proposed to play important roles in trafficking and signaling events. These functions are inhibited following putative disruption of rafts by cholesterol depletion, commonly induced by treatment with methyl-beta-cyclodextrin (MbetaCD). However, several studies showed that the lateral diffusion of membrane proteins is inhibited by MbetaCD, suggesting that it may have additional effects on membrane organization unrelated to cholesterol removal. Here, we investigated this possibility by comparison of the effects of cholesterol depletion by MbetaCD and by metabolic inhibition (compactin), and of treatment with alpha-CD, which does not bind cholesterol. The studies employed two series of proteins (Ras and influenza hemagglutinin), each containing as internal controls related mutants that differ in raft association. Mild MbetaCD treatment retarded the lateral diffusion of both raft and non-raft mutants, whereas similar cholesterol reduction (30-33%) by metabolic inhibition enhanced selectively the diffusion of the raft-associated mutants. Moreover, alpha-CD also inhibited the diffusion of raft and non-raft mutants, despite its lack of effect on cholesterol content. These findings suggest that the widely used treatment with CD to reduce cholesterol has additional, cholesterol-independent effects on membrane protein mobility, which do not necessarily distinguish between raft and non-raft proteins.
Preamble (1986)

For more than 30 years, Polymer Engineering & Science has been one of the most highly regarded journals in the field, serving as a forum for authors of treatises on the cutting edge of polymer science and technology.