gebhart/patrepeval huggingface dataset:
Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa (1987)

Different types of platelets in various types of plasma were subjected to levels of shear stress that produce irreversible platelet aggregation in normal platelet-rich plasma (PRP). At shear stresses of 90 or 180 dyne/cm2 applied for 30 seconds or five minutes, aggregation was either absent or only transient and reversible using severe von Willebrand's disease (vWD) PRP (less than 1% von Willebrand factor, vWF); Bernard-Soulier syndrome (BSS) PRP (platelets deficient in the membrane glycoprotein Ib, GPIb); normal PRP plus monoclonal antibody (MoAb) to GPIb; thrombasthenic PRP (platelets deficient in membrane glycoprotein IIb-IIIa complex, GPIIb-IIIa); and normal PRP plus MoAb to GPIIb-IIIa. Shear-induced aggregation was inhibited under the above conditions, even though the platelets were activated to release their granular contents. Sheared normal platelets in vWD plasma aggregated in response to added vWF. These studies demonstrate that the formation of stable platelet aggregates under conditions of high shear requires vWF and the availability of both GPIb and GPIIb-IIIa on platelet membranes. The experiments demonstrate that vWF-platelet interactions can occur in the absence of artificial agonists or chemical modification of vWF. They suggest a possible mechanism for platelet aggregation in stenosed or partially obstructed arterial vessels in which the platelets are subjected to relatively high levels of shear stress.
Application of ZSM-5/Aluminophosphates Composite Zeolite for Methanol to Olefins (2011)

ZSM-5/Aluminophosphates composite zeolite was hydrothermally synthesized by adding ZSM-5 powder into the synthesis solution of aluminophosphates,and was characterized by XRD, SEM,FT-IR,BET,NH_3-TPD and so on.The catalytic activity of composite zeolite was evaluated for methanol to olefins reaction.It was confirmed that composite zeolite had typical ZSM-5 and aluminophosphates structure.Both AlPO_4-5 and AlPO_4-18 phases were found in aluminophosphates.Compared with the ZSM-5,the acid strength and acid amount of composite zeolite were significantly decreased.The selectivities of light olefins(83.5%),ethylene(36.5%) propylene(36%) were higher and the selectivities of C_2—C_4 alkyl and C_(5+) were much lower in methanol to olefins reaction over the composite zeolite than that over pure ZSM-5,the mechanical mixture of ZSM-5 and aluminophosphates.
Compressive depth map acquisition using a single photon-counting detector: Parametric signal processing meets sparsity (2012)

Active range acquisition systems such as light detection and ranging (LIDAR) and time-of-flight (TOF) cameras achieve high depth resolution but suffer from poor spatial resolution. In this paper we introduce a new range acquisition architecture that does not rely on scene raster scanning as in LIDAR or on a two-dimensional array of sensors as used in TOF cameras. Instead, we achieve spatial resolution through patterned sensing of the scene using a digital micromirror device (DMD) array. Our depth map reconstruction uses parametric signal modeling to recover the set of distinct depth ranges present in the scene. Then, using a convex program that exploits the sparsity of the Laplacian of the depth map, we recover the spatial content at the estimated depth ranges. In our experiments we acquired 64×64-pixel depth maps of fronto-parallel scenes at ranges up to 2.1 M using a pulsed laser, a DMD array and a single photon-counting detector. We also demonstrated imaging in the presence of unknown partially-transmissive occluders. The prototype and results provide promising directions for non-scanning, low-complexity range acquisition devices for various computer vision applications.
A ‘microfluidic pinball’ for on-chip generation of Layer-by-Layer polyelectrolyte microcapsules (2011)

Inspired by the game of "pinball" where rolling metal balls are guided by obstacles, here we describe a novel microfluidic technique which utilizes micropillars in a flow channel to continuously generate, encapsulate and guide Layer-by-Layer (LbL) polyelectrolyte microcapsules. Droplet-based microfluidic techniques were exploited to generate oil droplets which were smoothly guided along a row of micropillars to repeatedly travel through three parallel laminar streams consisting of two polymers and a washing solution. Devices were prototyped in PDMS and generated highly monodisperse and stable 45±2 µm sized polyelectrolyte microcapsules. A total of six layers of hydrogen bonded polyelectrolytes (3 bi-layers) were adsorbed on each droplet within <3 minutes and a fluorescent intensity measurement confirmed polymer film deposition. AFM analysis revealed the thickness of each polymer layer to be approx. 2.8 nm. Our design approach not only provides a faster and more efficient alternative to conventional LbL deposition techniques, but also achieves the highest number of polyelectrolyte multilayers (PEMs) reported thus far using microfluidics. Additionally, with our design, a larger number of PEMs can be deposited without adding any extra operational or interfacial complexities (e.g. syringe pumps) which are a necessity in most other designs. Based on the aforementioned advantages of our device, it may be developed into a great tool for drug encapsulation, or to create capsules for biosensing where deposition of thin nanofilms with controlled interfacial properties is highly required.
Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration (2020)

Implantation of the PRIMA did not decrease the residual natural acuity, and it restored visual sensitivity in the former scotoma in each of the 5 patients. In 3 patients with the proper placement of the chip, prosthetic visual acuity was only 10% to 30% less than the level expected from the pixel pitch (20/420). Therefore, the use of optical or electronic magnification in the glasses as well as smaller pixels in future implants may improve visual acuity even further.
Systematic identification of non-coding pharmacogenomic landscape in cancer (2018)

Emerging evidence has shown long non-coding RNAs (lncRNAs) play important roles in cancer drug response. Here we report a lncRNA pharmacogenomic landscape by integrating multi-dimensional genomic data of 1005 cancer cell lines and drug response data of 265 anti-cancer compounds. Using Elastic Net (EN) regression, our analysis identifies 27,341 lncRNA-drug predictive pairs. We validate the robustness of the lncRNA EN-models using two independent cancer pharmacogenomic datasets. By applying lncRNA EN-models of 49 FDA approved drugs to the 5605 tumor samples from 21 cancer types, we show that cancer cell line based lncRNA EN-models can predict therapeutic outcome in cancer patients. Further lncRNA-pathway co-expression analysis suggests lncRNAs may regulate drug response through drug-metabolism or drug-target pathways. Finally, we experimentally validate that EPIC1, the top predictive lncRNA for the Bromodomain and Extra-Terminal motif (BET) inhibitors, strongly promotes iBET762 and JQ-1 resistance through activating MYC transcriptional activity.
Field emission current investigation of p-type and metallized silicon emitters in the frequency domain (2018)

We investigated two different field emitter arrays consisting of 10×10 p-type and 10×10 undoped Au-coated high aspect ratio silicon tips. The I-V characterization of the p-type sample showed a pronounced saturation for voltages higher than 500 V and a maximum emission current of 39 nA. The metallized sample revealed a FN-like emission up to several μA. The metallized and the p-type sample operating below the saturation region showed high current fluctuations of ±16%. Whereas, the metallized sample with current regulation and the p-type sample in the saturation yielded a current stability of ±0.4% and ±0.3%, respectively. Investigations in the frequency domain revealed the for field emission typical 1/f-noise. By operating in the saturation region (p-type sample) or using an emission current regulation (metallized sample) the noise level was reduced by at least 20 dB. Finally, the p-type sample was illuminated by a light emitting diode to increase and modulate the emission current in the saturation region. The emission current was increased by a factor of 3.7 to 145 nA. With this configuration we emulated an unstable emission behavior and evaluated the performance of our emission current regulation circuit.
Degradation of CT Low-Contrast Spatial Resolution Due to the Use of Iterative Reconstruction and Reduced Dose Levels (2015)

Purpose To determine the dose reduction that could be achieved without degrading low-contrast spatial resolution (LCR) performance for two commercial iterative reconstruction (IR) techniques, each evaluated at two strengths with many repeated scans. Materials and Methods Two scanner models were used to image the American College of Radiology (ACR) CT accreditation phantom LCR section at volume CT dose indexes of 8, 12, and 16 mGy. Images were reconstructed by using filtered back projection (FBP) and two manufacturers’ IR techniques, each at two strengths (moderate and strong). Data acquisition and reconstruction were repeated 100 times for each, yielding 1800 images. Three diagnostic medical physicists reviewed the LCR images in a blinded fashion and graded the visibility of four 6-mm rods with a six-point scale. Noninferiority and inferiority-superiority analyses were used to interpret the differences in LCR relative to FBP images acquired at 16 mGy. Results LCR decreased with decreasing dose for all reconstructions. Relative to FBP and full dose, 25%–50% dose reductions resulted in inferior LCR for vendors 1 and 2 for FBP and 25% dose reductions resulted in inferior and equivalent performance for vendor 1 and equivalent and superior performance for vendor 2 at moderate and strong IR settings, respectively. When dose was reduced by 50%, both IR techniques resulted in inferior LCR at both strength settings. Conclusion For radiation dose reductions of 25% or more, the ability to resolve the four 6-mm rods in the ACR CT accreditation phantom can be lost. © RSNA, 2015
Evaluation of erythrocyte autoantibodies with flow cytometric phagocytosis assay (2018)

Aims: Cellular assays such as the monocyte monolayer assay have been used to evaluate the clinical significance of antibodies to red blood cells (RBCs). Flow cytometry (FCM) has also been applied to antibody screening and diagnosing autoimmune hemolytic anemia (AIHA). Methods: RBC eluate from 131 patients with positive direct antiglobulin tests, along with three human monoclonal antibodies (two anti-D and one anti-Dib) were used to evaluate a new FCM two-color phagocytosis assay using markers that bind RBCs and monocytes. Dual-positive event percentages were compared with antibody titers and trimmed mean fluorescence intensity (MFI) from the 131 eluates and three monoclonal antibodies. Results: Percent positive by the FCM phagocytosis assay correlated well (R2=0.755) with trimmed-MFI in serial dilutions of two human IgG1 monoclonal antibodies, anti-D and anti-Dib, and 131 clinical samples with titers ranging from 2 to 2048. IgG2 antibodies showed lower phagocytosis relative to titers and MFI associated with these antibodies. Conclusion: The FCM phagocytosis assay can be used to evaluate AIHA-associated antibodies, with great potential to standardize immunohematology testing, especially in regard to establishing the clinical significance of RBC alloantibodies.
Coherent Control of Chemical Reactions (1999)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoherent Control of Chemical ReactionsRobert J. Gordon, Langchi Zhu, and Tamar SeidemanView Author Information Department of Chemistry (m/c 111), University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061 The Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa K1A 0R6, Canada Cite this: Acc. Chem. Res. 1999, 32, 12, 1007–1016Publication Date (Web):November 3, 1999Publication History Received22 December 1998Published online3 November 1999Published inissue 1 December 1999https://pubs.acs.org/doi/10.1021/ar970119lhttps://doi.org/10.1021/ar970119lresearch-articleACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views983Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ionization,Lasers,Phase transitions,Resonance structures,Scattering Get e-Alerts
Texture Feature Analysis for Different Resolution Level of Kidney Ultrasound Images (2017)

Image feature extraction is a technique to identify the characteristic of the image. The objective of this work is to discover the texture features that best describe a tissue characteristic of a healthy kidney from ultrasound (US) image. Three ultrasound machines that have different specifications are used in order to get a different quality (different resolution) of the image. Initially, the acquired images are pre-processed to de-noise the speckle to ensure the image preserve the pixels in a region of interest (ROI) for further extraction. Gaussian Low- pass Filter is chosen as the filtering method in this work. 150 of enhanced images then are segmented by creating a foreground and background of image where the mask is created to eliminate some unwanted intensity values. Statistical based texture features method is used namely Intensity Histogram (IH), Gray-Level Co-Occurance Matrix (GLCM) and Gray-level run-length matrix (GLRLM).This method is depends on the spatial distribution of intensity values or gray levels in the kidney region. By using One-Way ANOVA in SPSS, the result indicated that three features (Contrast, Difference Variance and Inverse Difference Moment Normalized) from GLCM are not statistically significant; this concludes that these three features describe a healthy kidney characteristics regardless of the ultrasound image quality.
Immunizations during HIV infection (1998)

The safety and efficacy of immunizing HIV-infected persons for other diseases has been controversial. Transient increases in HIV viral load have been reported in some but not all studies of immunization, and are unlikely to have adverse clinical consequences, particularly in the era of more active antiretroviral therapy. Although the serological response to immunization is reduced in the HIV-infected host, recent data suggest that it has some clinical efficacy.
Status of HVCMOS developments for ATLAS (2017)

This paper describes the status of the developments made by ATLAS HVCMOS and HVMAPS collaborations. We have proposed two HVCMOS sensor concepts for ATLAS pixels—the capacitive coupled pixel detector (CCPD) and the monolithic detector. The sensors have been implemented in three semiconductor processes AMS H18, AMS H35 and LFoundry LFA15. Efficiency of 99.7% after neutron irradiation to 1015 neq/cm2W has been measured with the small area CCPD prototype in AMS H18 technology. About 84% of the particles are detected with a time resolution better than 25 ns. The sensor was implemented on a low resistivity substrate. The large area demonstrator sensor in AMS H35 process has been designed, produced and successfully tested. The sensor has been produced on different high resistivity substrates ranging from 80 Ωcm to more than 1 kΩ. Monolithic- and hybrid readout are both possible. In August 2016, six different monolithic pixel matrices for ATLAS with a total area of 1 cm2 have been submitted in LFoundry LFA15 process. The matrices implement column drain and triggered readout as well as waveform sampling capability on pixel level. Design details will be presented.
Multimedia processor architecture (2002)

The paper describes trends in the development of multimedia processor architecture that may be predicted on the basis of the availability of an ASIC with 10s of millions of gates. Multimedia processing based upon multi granular parallelism for diverse media needs supercomputing power for multi threaded, process level execution. Due to the appearance of large scale integration (LSI) for what has been termed system on silicon, a new scheme for building the multimedia centric processor will be realized. The paper proposes advanced implementation technologies for multimedia acceleration employing a reconfigurable architecture and using hundreds of processing elements embedded within an ASIC. Accelerated functions considered in this proposal include 3D graphic and 3D audio rendering, and implementation of video and audio codecs. Computational efficiency for advanced applications, such as walk through virtual reality (VR), is maximized by sharing the results of geometric calculations that are required both for graphics and audio rendering.
Synthesis and chemical properties of N- and O-phosphorylated derivatives of creatinol. (1979)

N-Methyl-N-(beta-hydroxyethyl)-guanidine O-phosphate (creatinol O-phosphate) was synthesized from creatinol by phosphorylation with partially hydrolyzed phosphoryl chloride or by dehydration of its phosphate salt. Creatinol N-phosphate was obtained by addition of N-methylamino ethanol to bis-p-nitrobenzylphosphocyanamide, followed by hydrogenolysis. The chemical properties of both compounds were investigated; creatinol N-phosphate was rearranged to creatinol O-phosphate by heating.
A 0.35-/spl mu/m CMOS analog turbo decoder for the 40-bit rate 1/3 UMTS channel code (2005)

This work presents the design and the test results of an analog decoder for the 40-bit block length, rate 1/3, Turbo Code defined in the UMTS standard. The prototype is fully integrated in a three-metal double-poly 0.35-/spl mu/m CMOS technology, and includes an I/O interface that maximizes the decoder throughput. After the successful implementation of proof-of-concept analog iterative decoders by different research groups in both bipolar and CMOS technologies, this is the first reported prototype of an analog decoder for a realistic error-correcting code. The decoder was successfully tested at the maximum data rate defined in the standard (2 Mb/s), with an overall power consumption of 10.3 mW at 3.3 V, going down to 7.6 mW with the decoder core operated at 2 V, and an extremely low energy per decoded bit and trellis state (0.85 nJ for the decoder core alone).
Polymer‐modified halloysite composite nanotubes (2008)

Abstract A natural clay halloysite, which is a kind of aluminosilicate with a predominantly nanosized hollow tubular structure, was modified by polymers achieving polymer‐halloysite composite nanotubes. Polymer chains can grow from both interior and exterior surfaces of the halloysite nanotubes by atom transfer radial polymerization (ATRP). Eventually, the composite nanotubes were evolved to a core‐shell coaxial structure after the interior cavity was fully covered by the polymer. After dissolution of the halloysite template, polymeric nanotubes and nanowires were derived. The composition could be controlled from polymer to carbon after being treated at high temperature. The idea can be extended to a cast halloysite fabric resulting nonwoven composites, which had some interesting wettability. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
The Angiopoietin-like Proteins ANGPTL3 and ANGPTL4 Inhibit Lipoprotein Lipase Activity through Distinct Mechanisms (2008)

Two members of the angiopoietin-like family of proteins, ANGPTL3 and ANGPTL4, have been shown to play important roles in modulating lipoprotein metabolism in the body. Both proteins were found to suppress lipoprotein lipase (LPL) activity in vitro as well as in vivo. However, their mechanisms of inhibition remained poorly understood. Using enzyme kinetic analysis with purified recombinant proteins, we have found key mechanistic differences between ANGPTL3 and ANGPTL4. ANGPTL3 reduced LPL catalytic activity but did not significantly alter its self-inactivation rate. In contrast, ANGPTL4 suppressed LPL by accelerating the irreversible inactivation of LPL. Furthermore, heparin was able to overcome the inhibitory effect of ANGPTL3 on LPL but not that of ANGPTL4. Site-directed mutagenesis demonstrated the critical function of Glu(40) in ANGPTL4. In contrast, when cysteine residues involved in disulfide bond formation were mutated to serines, ANGPTL4 retained its activity. Taken together, our data provide a more detailed view of the structure and mechanisms of these proteins. The finding that ANGPTL3 and ANGPTL4 inhibit LPL activity through distinct mechanisms indicates that the two proteins play unique roles in modulation of lipid metabolism in vivo.
<title>Human eye interfaced segmentation and multiple video object coding</title> (2003)

In the general multiple video object coder, more interesting objects such as a speaker or a moving object is consistently coded with higher priority. Since the priority of each object may not be fixed in the whole sequence and be variable on a frame by frame basis, it must be adjusted in a frame. In this paper, we analyze the independent rate control algorithm and the global algorithm that the QP value is controlled by static parameters, object importance or priority, the target PSNR and the weighted distortion. The priority among static parameters is analyzed and adjusted into dynamic parameters according to the visual interests or importance obtained by a camera interface. The target PSNR and the weighted distortion are proportional to magnitude, motion, and distortion. We apply these parameters for the weighted distortion control and the priority-based control leading to an efficient bit-rate distribution. As result, we have achieved that fewer bits are allocated for video objects which have less importance and more bits for those which have higher visual importance. The period to reach stability in the visual quality is reduced to less than 15 frames of the coded sequence. With respect to the PSNR, the proposed scheme shows higher quality of over 2dB than the conventional schemes. Thus the coding scheme interfaced to human-eyes proves to be an efficient video coder dealing with the multiple video objects.
Induction of c-fos by prostaglandin F2 alpha in human ciliary smooth muscle cells. (1994)

Exposure of ciliary smooth muscle cells to either PGF2 alpha or 17-phenyltrinor-PGF2 alpha induces an immediate early gene expression response that is similar to c-Fos induction in other cell systems. These results establish the basis for future investigations evaluating the potential role of c-fos induction in mediating the effects of PGF2 alpha on uveoscleral outflow.
Polyaniline: synthesis and characterization of pernigraniline base (1990)

The synthesis and characterization of free-standing flexible films and powder forms of pernigraniline base, the fully oxidized form of polyaniline, by the oxidation of emeraldine base with m-chloroperbenzoic acid is reported.