gebhart/patrepeval huggingface dataset:
Limited Infiltration of Exogenous Dendritic Cells and Naive T Cells Restricts Immune Responses in Peripheral Lymph Nodes (2006)

Primary CD8 T cell responses in lymph nodes (LN) and protective immunological tumor control are quantitatively limited following immunization with exogenous peptide-pulsed dendritic cells (DC). This arises from two constraints. First, LN are saturated by relatively small quantities of exogenous DC. Second, circulation of new naive T cells into DC-infiltrated LN during the functional lifespan of the DC is negligible. Limits on DC and T cellularity in, and flux through, LN constrain the magnitude of both primary and subsequent recall responses. Enhanced immune responses and tumor control can be achieved using maneuvers to augment LN retention of DC or availability of naive T cells to Ag-presenting DC. These data offer an increased understanding of LN function in general and provide a practical basis for improvements in tumor immunotherapy.
The phase behavior of hydrated cholesterol. (1979)

The thermotropic phase behavior of cholesterol monohydrate in water was investigated by differential scanning calorimetry, polarizing light microscopy, and x-ray diffraction. In contrast to anhydrous cholesterol which undergoes a polymorphic crystalline transition at 39 degrees C and a crystalline to liquid transition at 151 degrees C, the closed system of cholesterol monohydrate and water exhibited three reversible endothermic transitions at 86, 123, and 157 degrees C. At 86 degrees C, cholesterol monohydrate loses its water of hydration, forming the high temperature polymorph of anhydrous cholesterol. At least 24 hours were required for re-hydration of cholesterol and the rate of hydration was dependent on the polymorphic crystalline form of anhydrous cholesterol. At 123 degrees C, anhydrous crystalline cholesterol in the presence of excess water undergoes a sharp transition to a birefringent liquid crystalline phase of smectic texture. The x-ray diffraction pattern obtained from this phase contained two sharp low-angle reflections at 37.4 and 18.7 A and a diffuse wide-angle reflection centered at 5.7 A, indicating a layered smectic type of liquid crystalline structure with each layer being two cholesterol molecules thick. The liquid crystalline phase is stable over the temperature range of 123 to 157 degrees C before melting to a liquid dispersed in water. The observation of a smectic liquid crystalline phase for hydrated cholesterol correlates with its high surface activity and helps to explain its ability to exist in high concentrations in biological membranes.
High-power constant-index lens antennas (1974)

The results of a study to develop a high temperature dielectric lens antenna for use in the microwave frequency range are presented. The design and fabrication of spherical and hemispherical constant-index lenses are described. Radiation patterns, gain, polarization, and VSWR characteristics of spherical and hemispherical constant-index dielectric lens antennas over the frequency range from 2 to 11 GHz are presented. The results from high-power testing of both spherical and hemispherical constant-index lenses at a 2 kW average power level indicate that this power level causes no degradation in the performance of the lenses.
Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE) (2018)

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent lipid mediator that induces tissue eosinophilia via the selective OXE receptor (OXE-R), which is an attractive therapeutic target in eosinophilic diseases. We previously identified indole OXE-R antagonists that block 5-oxo-ETE-induced primate eosinophil activation. Although these compounds possess good oral absorption, their plasma levels decline rapidly due to extensive oxidation of their hexyl side chain. We have now succeeded in dramatically increasing antagonist potency and resistance to metabolism by replacing the hexyl group with phenylpentyl or phenylhexyl side chains. Compared with our previous lead compound S-230, our most potent antagonist, S-C025, has an IC<sub>50</sub> (120 pM) over 80 times lower and a substantially longer plasma half-life. A single major metabolite, which retains antagonist activity (IC<sub>50</sub>, 690 pM) and has a prolonged lifetime in plasma was observed. These new highly potent OXE-R antagonists may provide a novel strategy for the treatment of eosinophilic disorders like asthma.
The Chemokine Receptor CX<sub>3</sub>CR1 Mediates Homing of MHC class II-Positive Cells to the Normal Mouse Corneal Epithelium (2007)

This study has identified a role for CX(3)CR1 in the normal recruitment of MHC class II(+) putative DCs into the corneal epithelium and establishes a model for investigating monocyte-derived cells and fractalkine/CX(3)CR1 interactions during corneal disease.
LASER INDUCED BREAKDOWN SPECTROSCOPY OF LIQUID AND SOLID SAMPLES IN THE PRESENCE OF MAGNETIC FIELD (2002)

Investigation of optical emission from laser-produced plasma expanding across an external magnetic field is the subject of current interest and has its application in various field of research[1-2]. It is well known that various external parameters such as energy and wavelength of the laser, electric and magnetic field, and ambient condition, affects the plasma parameters and emission properties. The effects of magnetic field on the emission properties of laser-produced plasma have been studied earlier [1-2]. During the process of plasma expansion (deceleration in the presence of magnetic field), the kinetic energy of the plasma is totally transformed into thermal energy of the plasma as well as in the energy of the magnetic field. In this situation, the plasmas emission as well as its various other physical properties change. Effect of magnetic field on the emission from the laser-produced plasma has been studied by many authors from X-ray to visible wavelength range at different experimental conditions. Laser Induced Breakdown Spectroscopy (LIBS) is a laser based diagnostics technique, which has been used to study the atomic emission from various samples such as solid, liquid or gas [3]. In the light of the above discussion, it will be interesting to study the effect of a low intensity steady magnetic field on the LIBS signal from liquid as well as solid samples, which will be important for trace element analysis. In the present experiment we have studied the emission properties of the laser-produced plasma from the metal seeded liquid samples as well as aluminum alloy in the presence of magnetic field.
Comparison of BISAP, Ranson's, APACHE-II, and CTSI Scores in Predicting Organ Failure, Complications, and Mortality in Acute Pancreatitis (2009)

We confirmed that the BISAP score is an accurate means for risk stratification in patients with AP. Its components are clinically relevant and easy to obtain. The prognostic accuracy of BISAP is similar to those of the other scoring systems. We conclude that simple scoring systems may have reached their maximal utility and novel models are needed to further improve predictive accuracy.
Methods of analysis by the U.S. Geological Survey Organic Geochemistry Research Group; determination of chloroacetanilide herbicide metabolites in water using high-performance liquid chromatography-diode array detection and high-performance liquid chromatography/mass spectrometry (2000)

Analytical methods using high-performance liquid chromatography-diode array detection (HPLC-DAD) and high-performance liquid chromatography/mass spectrometry (HPLC/MS) were developed for the analysis of the following chloroacetanilide herbicide metabolites in water: acetochlor ethanesulfonic acid (ESA), acetochlor oxanilic acid (OXA), alachlor ESA, alachlor OXA, metolachlor ESA, and metolachlor OXA. Good precision and accuracy were demonstrated for both the HPLC-DAD and HPLC/MS methods in reagent water, surface water, and ground water. The mean HPLC-DAD recoveries of the chloroacetanilide herbicide metabolites from water samples spiked at 0.25, 0.50, and 2.0 mg/L (micrograms per liter) ranged from 84 to 112 percent, with relative standard deviations of 18 percent or less. The mean HPLC/MS recoveries of the metabolites from water samples spiked at 0.05, 0.20, and 2.0 mg/L ranged from 81 to 125 percent, with relative standard deviations of 20 percent or less. The limit of quantitation (LOQ) for all metabolites using the HPLC-DAD method was 0.20 mg/L, whereas the LOQ using the HPLC/MS method was 0.05 mg/L. These metabolite-determination methods are valuable for acquiring information about water quality and the fate and transport of the parent chloroacetanilide herbicides in water.
Multiplexing scheme of helper signals on bars in EDTV-II (1994)

Wide-aspect-ratio TV with improved video and audio is being studied worldwide. In Japan, EDTV (extended definition TV) systems that are compatible with current TV systems, are being studied by the BTA (Broadcasting Technology Association), and are called EDTV-II. This paper deals with a multiplexing scheme of helper signals in EDTV-II. We briefly introduce the background of EDTV-II to aid in understanding the proposed scheme, which is based on BTA suggestions. In EDTV-II, a letterbox format is chosen for the wide aspect ratio, and HH (horizontal high), VH (vertical high) and VT (vertical-temporal) signals are transmitted as helper signals. We propose a scheme in which both VT and VH signals are multiplexed on different spaces in the vertical-temporal frequency domain, and we subjectively assess the proposed scheme from the viewpoint of the visibility of the bars. As a result, the optimal multiplexing method is clarified.
EGEON: Software-Defined Data Protection for Object Storage (2022)

With the growth in popularity of cloud computing, object storage systems (e.g., Amazon S3, OpenStack Swift, Ceph) have gained momentum for their relatively low per-GB costs and high availability. However, as increasingly more sensitive data is being accrued, the need to natively integrate privacy controls into the storage is growing in relevance. Today, due to the poor object storage interface, privacy controls are enforced by data curators with full access to data in the clear. This motivates the need for a new approach to data privacy that can provide strong assurance and control to data owners. To fulfill this need, this paper presents EGEON, a novel software-defined data protection framework for object storage. EGEON enables users to declaratively set privacy policies on how their data can be shared. In the privacy policies, the users can build complex data protection services through the composition of data transformations, which are invoked inline by EGEON upon a read request. As a result, data owners can trivially display multiple views from the same data piece, and modify these views by only updating the policies. And all without restructuring the internals of the underlying object storage system. The EGEON prototype has been built atop OpenStack Swift. Evaluation results shows promise in developing data protection services with little overhead directly into the object store. Further, depending on the amount of data filtered out in the transformed views, end-to-end latency can be low due to the savings in network communication.
Effects of diet and chemical form of selenium on selenium metabolism in sheep. (1997)

The effects of diet composition and chemical form of Se on intestinal flow, absorption, and retention of Se were determined in sheep by the balance technique and by disappearance of Se from sites along the gastrointestinal tract with reference to dual-phase digesta markers. Six sheep with ruminal and duodenal cannulas were used in a crossover design with a split-plot arrangement of the Se isotope treatments. Sheep were fed a forage (alfalfa hay)-based (.37 mg Se/kg) or concentrate (barley)-based (.27 mg Se/kg) diet at 90% of ad libitum intake. Selenium stable isotopes (enriched [77Se]yeast, enriched [82Se]selenite) and fluid (Co-EDTA) and particulate (Cr-mordanted fiber) markers were administered simultaneously into the rumen four times daily for 7 d, and total collections of feces and urine were made every 24 h for these and the following 7 d. A larger proportion (51 to 61%) of the Se tracers flowing to the duodenum was associated with the particulate fraction, mainly as bacteria-associated Se, than with the fluid fraction. The [82Se]selenite was more available (P < .05) for absorption and retention than [77Se]yeast, indicating that inorganic chemical forms of Se are as available to the ruminant as organic forms of Se commonly found in feedstuffs. Selenium absorption and retention were greater (P < .05) in sheep receiving the concentrate-based diet than in sheep receiving the forage-based diet. Thus, the availability of Se from inorganic and organic sources in sheep seems to be influenced by diet composition.
Self-splitting modular neural network - domain partitioning at boundaries of trained regions (2008)

A modular neural network works by dividing the input domain into segments, assigning a separate neural network to each sub-domain. This paper introduces the self-splitting modular neural network, in which the partitioning of the input domain occurs during training. It works by first attempting to solve a problem with a single network. If that fails, it finds the largest chunk of the input domain that was successfully solved, and sets that aside. The remaining unsolved portion(s) of the input domain are then recursively solved according to the same strategy. Using standard backpropagation, several large problems are shown to be solved quickly and with excellent generalization, with very little tuning, using this divide-and-conquer approach.
Forward-Looking Element Recognition Based on the LSTM-CRF Model with the Integrity Algorithm (2019)

A state-of-the-art entity recognition system relies on deep learning under data-driven conditions. In this paper, we combine deep learning with linguistic features and propose the long short-term memory-conditional random field model (LSTM-CRF model) with the integrity algorithm. This approach is primarily based on the use of part-of-speech (POS) syntactic rules to correct the boundaries of LSTM-CRF model annotations and improve its performance by raising the integrity of the elements. The method incorporates the advantages of the data-driven method and dependency syntax, and improves the precision rate of the elements without losing recall rate. Experiments show that the integrity algorithm is not only easy to combine with the other neural network model, but the overall effect is better than several advanced methods. In addition, we conducted cross-domain experiments based on a multi-industry corpus in the financial field. The results indicate that the method can be applied to other industries.
Lithium ion conduction in rapidly quenched Li2O-Al2O3, Li2O-Ga2O3, and Li2O-Bi2O3 glasses (1980)

Glasses containing Al2O3, Ga2O3, and Bi2O3 with Li2O have been prepared by twin roller quenching. These glasses are found to exhibit reasonably high ionic conductivities and low electronic conductivities for Li2O concentrations exceeding 50 mole %. The conductivity increases rapidly with increasing Li2O content but does not differ greatly from system to system despite the large difference in the ionic radii of the trivalent cations, Al3+, Ga3+, and Bi3+ . A simple model for the behavior is discussed.
Activation of the calcium-sensing receptor attenuates TRPV6-dependent intestinal calcium absorption (2019)

Plasma calcium (Ca2+) is maintained by amending the release of parathyroid hormone and through direct effects of the Ca2+ sensing receptor (CaSR) in the renal tubule. Combined, these mechanisms alter intestinal Ca2+ absorption by modulating 1,25-dihydroxy vitamin D3 production, bone resorption, and renal Ca2+ excretion. The CaSR is a therapeutic target in the treatment of secondary hyperparathyroidism and hypocalcemia a common complication of calcimimetic therapy. The CaSR is also expressed in intestinal epithelium, however, a direct role in regulating local intestinal Ca2+ absorption is unknown. Chronic CaSR activation decreased expression of genes involved in Ca2+ absorption. In Ussing chambers, increasing extracellular Ca2+ or basolateral application of the calcimimetic cinacalcet decreased net Ca2+ absorption across intestinal preparations acutely. Conversely, Ca2+ absorption increased with decreasing extracellular Ca2+ concentration. These responses were absent in mice expressing a non-functional TRPV6, TRPV6D541A. Cinacalcet also attenuated Ca2+ fluxes through TRPV6 in Xenopus oocytes when co-expressed with the CaSR. Moreover, the phospholipase C inhibitor, U73122, prevented cinacalcet-mediated inhibition of Ca2+ flux. These results reveal a regulatory pathway whereby activation of the CaSR in the basolateral membrane of the intestine directly attenuates local Ca2+ absorption via TRPV6 to prevent hypercalcemia and help explain how calcimimetics induce hypocalcemia.
Neurosteroids act on the GABAA receptor at sites on the N-terminal side of the middle of TM2 (1998)

Two sets of chimeras between alphaxalone-sensitive GABA(A) receptor alpha2 or beta1 subunits and the alphaxalone-insensitive glycine receptor alpha1 subunit were constructed to determine the structural domains important for the modulatory actions of neuroactive steroids. These data suggest that the site of action for neurosteroids on GABA(A) receptors is not the same as that for volatile anesthetics and ethanol, but is on the N-terminal side of the middle of TM2.
Applications of short-range radars on the base of ultrashort pulse single chip (2017)

Technologies of creation of ultrashort pulse systems of near-radar location are considered. Benefits and applications of single-crystal radar transceivers for radiation and reception of ultrashort impulses are described. Results of measurements of ultrashort impulse from an output of the generator of XeThru-Novelda radar microchip (Norway) and results of simulation of ultrawideband antennas are given. The features of the radiation of ultrashort pulses by ultrawideband Vivaldi antenna are considered. Developed applications of ultrashort pulse radar systems are described.
Skin biomedical optical imaging system using dual-wavelength polarimetric control with liquid crystals (2010)

Spectropolarimetric skin imaging is becoming an attractive technique for early detection of skin cancer. Using two liquid crystal retarders in combination with a dual-band passive spectral filter and two linear polarizers, we demonstrate the spectral and polarimetric imaging of skin tissue in the near infrared. Based on this concept, a compact prototype module has been built and is being used for clinical evaluation.
HDR Deghosting: How to Deal with Saturation? (2013)

We present a novel method for aligning images in an HDR (high-dynamic-range) image stack to produce a new exposure stack where all the images are aligned and appear as if they were taken simultaneously, even in the case of highly dynamic scenes. Our method produces plausible results even where the image used as a reference is either too dark or bright to allow for an accurate registration.
Ice Anesthesia for Injection of Dermal Fillers (2010)

*Private Practice, Niagara Falls, Ontario, Canada Address correspondence and reprint requests to: Kevin C. Smith, MD, FRCPC (Dermatology), Suite 201 – 6453 Morrison St. Niagara Falls, Ontario, Canada L2E 7H1, or e-mail: [email protected] Kevin Smith, MD, FRCPC, has indicated no significant interest with commercial supporters.
A general framework for the analysis and design of tubular linear permanent magnet machines (1999)

A general framework for the analysis and design of a class of tubular linear permanent magnet machines is described. The open-circuit and armature reaction magnetic field distributions are established analytically in terms of a magnetic vector potential and cylindrical coordinate formulation, and the results are validated extensively by comparison with finite element analyses. The analytical field solutions allow the prediction of the thrust force, the winding emf, and the self- and mutual-winding inductances in closed forms. These facilitate the characterization of tubular machine topologies and provide a basis for comparative studies, design optimization, and machine dynamic modeling. Some practical issues, such as the effects of slotting and fringing, have also been accounted for and validated by measurements.
Decentralized WIP-oriented manufacturing control (DEWIP) (2003)

DEWIP is a manufacturing control system for job shop environments aiming at achieving short and reliable lead times by establishing WIP control loops between the manufacturing work centres. The paper describes the mode of function, the setting of parameters and simulation results of the new manufacturing control system. The setting of parameters is done with the aid of the funnel model and the theory of logistic operating curves, both developed at the Institute of Production Systems at the University of Hanover. The simulation is conducted using industrial data and makes it possible to assess DEWIP with regard to lead times, WIP level, performance and schedule reliability. DEWIP is compared both with an uncontrolled process and with the manufacturing control systems Load oriented order release (LOOR), Conwip and Polca. The results suggest that DEWIP and the models employed for the setting of parameters are suitable for job shop production and therefore offer a valuable alternative to prevailing centralized manufacturing control systems.
Synthesis and Properties of Esterification Products of Some Oxyethylated Alcohols and Alkylphenols with Fatty Acids (1980)

Abstract Some esterification products were prepared from oxyethylated alcohols and alkylphenols using stearic and oleic acids. The functional properties of the products were estimated. It was found that they displayed good emulsifying and dispersing ability and did not exhibit any foaming power, at all. In an alkaline medium they also show a washing power due to a gradually proceeding hydrolysis.
Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation (1975)

Adenosine is a possible mediator of myocardial and skeletal muscle blood flow regulation. Whether adenosine plays a similar role in modulating the pulmonary pressor response to acute alveolar hypoxia is not known. Adenosine levels (nmol/g tissue) in lung in six dogs ventilated with 95% N2, and 5% CO2 for a period of 3 min increased nearly 10-fold. Inosine and hypoxanthine, adenosine enzymatic degradation products, sustained a 10- and 7-fold increase, respectively. These degradative products are mainly formed in the capillary endothelial cells that contain the degradative enzyme nucleoside phosphorylase as demonstrated by histochemical techniques. To determine the effect of ATP, ADP, AMP, and adenosine on the pulmonary circulation, the in situ left lower lobe of 10 dogs was perfused at either free flow or constant flow via its pulmonary artery. ATP and ADP increased lobar vascular resistance; AMP and adenosine decreased the resistance. During hypoxic ventilation, adenosine infusions (100 nmol/ml blood) entirely abolished the increase in vascular resistance that was due solely to hypoxia. Dipyridamole produced similar responses. These data indicate that adenosine is a pulmonary vasodilator and that it may modulate the pulmonary pressor response to acute alveolar hypoxia. The findings suggest that the use of adenosine or dipyridamole may be beneficial in patients with pathologic elevations of the pulmonary vascular resistance which are a result of an exaggerated pulmonary pressor response to hypoxia, as seen in high-altitude pulmonary edema or that following cerebral injury.