gebhart/patrepeval huggingface dataset:
[Therapy of endometriosis with dienogest]. (1987)

Dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one, VEB Jenapharm, Jena, GDR), an orally active 19-nortestosterone derivative, was used firstly in the treatment of endometriosis. 57 patients (age 17-45 years) have been entered into the study. The diagnosis was confirmed by laparoscopy or laparotomy in 56 cases and in one case clinically. All patients have been treated with 2 mg dienogest per day in a progestin only regimen over a period of 6 month. The day after completing the course of dienogest therapy 51 patients underwent laparoscopy for control. On this basis endometriotic lesions had completely disappeared in 66.7%; in 80.4% a marked improvement was noted, but no effect was visible in 19.6% of the implants. Eighty-four per cent of the women reported symptomatic improvement. The efficacy of dienogest was correlated negative with the age of the treated women. The major side effects were spottings and decrease of libido. Blood pressure as well as mean body weight remained unaltered. No patient discontinued dienogest therapy due to side effects.
Dual-gate pentacene organic field-effect transistors based on a nanoassembled SiO2 nanoparticle thin film as the gate dielectric layer (2005)

In this paper, we report the fabrication of dual-gate organic field-effect transistors (OFETs) using self-assembled SiO2 and thermal oxide as gate dielectric materials and pentacene as a semiconductor. The top dielectric layer was formed by the low-cost and low-temperature self-assembly with SiO2 nanoparticles 45nm in diameter. The fabricated dual-gate pentacene field-effect transistor (FET) has a threshold voltage of −2.2V, a field-effect mobility of 0.1cm2∕Vs, an Ion∕off ratio of 3.8×103, and a slope of 1.3V∕decade. Compared to a single gate OFET, dual-gate FET has better performance with higher drain output current at the relatively low operating voltage, larger field-effect mobility, and better channel controllability by separately adjusting two gate biases.
Neutrophil Fate in Gingival Crevicular Fluid (2010)

The fate of the neutrophils within the inflammatory exudate in the periodontal crevice and their possible participation in the formation of neutrophil extracellular traps (NETs) are of clinical interest. However, the cytological analysis of clinical samples of inflammatory exudate is restricted by the obtainable quantities, which do not enable employing the routine approaches. Clinical examinations, ACLAR strip sampling, scanning electron microscopy, and confocal laser scanning microscopy were employed to analyze purulent crevicular exudate and gingival crevicular fluid in periodontitis. Bacteria, neutrophil activation, NETosis stages, and NETs were identified by molecular probe, expression of citrullinated histone H3, enzymatic digestion, and ultrastructurally. Crevicular neutrophils, all in diverse NETosis stages marked by the histone citrullination, and an abundance of NETs were found in both purulent crevicular exudate and gingival crevicular fluid. Largely varying quantities of dispersed crevicular bacteria were entrapped by NETs, but no phagocytized bacteria were evident in gingival crevicular fluid. The offered method enables for the first time the demonstration NETs in gingival crevicular fluid. The histone citrullination of all the floating crevicular neutrophils indicates that they all undergo NETosis.
High-Density Peptide Microarray Analysis of IgG Autoantibody Reactivities in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients (2016)

Intrathecal immunoglobulin G (IgG) synthesis and oligoclonal IgG bands in cerebrospinal fluid (CSF) are hallmarks of multiple sclerosis (MS), but the antigen specificities remain enigmatic. Our study is the first investigating the autoantibody repertoire in paired serum and CSF samples from patients with relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and other neurological diseases by the use of high-density peptide microarrays. Protein sequences of 45 presumed MS autoantigens (e.g.MOG, MBP, and MAG) were represented on the microarrays by overlapping 15mer peptides. IgG reactivities were screened against a total of 3991 peptides, including also selected viral epitopes. The measured antibody reactivities were highly individual but correlated for matched serum and CSF samples. We found 54 peptides to be recognized significantly more often by serum or CSF antibodies from MS patients compared with controls (pvalues <0.05). The results for RRMS and PPMS clearly overlapped. However, PPMS patients presented a broader peptide-antibody signature. The highest signals were detected for a peptide mapping to a region of the Epstein-Barr virus protein EBNA1 (amino acids 392-411), which is homologous to the N-terminal part of human crystallin alpha-B. Our data confirmed several known MS-associated antigens and epitopes, and they delivered additional potential linear epitopes, which await further validation. The peripheral and intrathecal humoral immune response in MS is polyspecific and includes antibodies that are also found in serum of patients with other diseases. Further studies are required to assess the pathogenic relevance of autoreactive and anti-EBNA1 antibodies as well as their combinatorial value as biomarkers for MS.
Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs (2019)

Applying artificial intelligence to the ECG allows prediction of patient sex and estimation of age. The ability of an artificial intelligence algorithm to determine physiological age, with further validation, may serve as a measure of overall health.
Superimposed Training for Channel Shortening Equalization in OFDM (2006)

In orthogonal frequency division multiplexing (OFDM) systems, the cyclic prefix (CP) is required to be greater than the length of the channel impulse response to avoid inter-block interference. However, a long CP decreases power and bandwidth efficiences. Recently channel shortening equalizers (CSEs) have been introduced to enable the use of a shorter CP, but they either require perfect channel knowledge, or demand high complexity and long decoding delay when the channel is unknown. In this paper, we propose a low complexity CSE for OFDM with unknown channels by using superimposed training. Our unique design achieves bandwidth efficient channel estimation, and low complexity channel shortening equalization as well as symbol decoding. Simulation results demonstrate the effectiveness of the proposed scheme.
[The hearing and vestibular evoked myogenic potentials test in patients with primary benign paroxysmal positional vertigo]. (2015)

oVEMP detection positive rate of primary BPPV is higher than cVEMP,which may be due to otolithic particles falling from the utricle; positive rate of cVEMP in primary BPPV with hearing loss is higher than that of oVEMP, which may related to the cochlear and sacculus occured in the same embryonic tissue structure.
Immune checkpoint blockade therapy for bladder cancer treatment (2016)

Bladder cancer remains the most immunogenic and expensive malignant tumor in the United States today. As the 4th leading cause of death from cancer in United States, Immunotherapy blocking immune checkpoints have been recently been applied to many aggressive cancers and changed interventions of urological cancers including advanced bladder cancer. The applied inhibition of PD-1-PD-L1 interactions can restore antitumor T-cell activity and enhance the cellular immune attack on antigens. The overall goals of this short review article are to introduce current cancer immunotherapy and immune checkpoint inhibitors, and to provide new insight into the underlying mechanisms that block immune checkpoints in tumor microenvironment. Furthermore, this review will address the preclinical and clinical trials to determine whether bladder cancer patients could benefit from this new cancer therapy in near future.
Murine macrophage scavenger receptor: <i>in vivo</i> expression and function as receptor for macrophage adhesion in lymphoid and non‐lymphoid organs (1995)

Abstract Macrophage scavenger receptors are trimeric integral membrane glycoproteins which have been implicated in various macrophage functions including uptake of oxidized lipoprotein and the serum‐dependent, divalent cation‐independent adhesion of macrophages to tissue culture‐treated plastic. In this study we have used a recently defined monoclonal antibody (2F8) which recognizes murine macrophage scavenger receptor, to explore its expression in lymphoid and non‐lymphoid organs of the normal adult. Scavenger receptor was detected in the red pulp and marginal zone of normal adult mouse spleen, medulla of the thymus and subcapsular region of lymph nodes. Kupffer cells in the liver, alveolar macrophages in the lung and lamina propria macrophages in the gut all reacted with 2F8 monoclonal antibody. The antigen was not detected on any nonmacrophage cells, with the exception of sinusoidal endothelial cells in the liver. In the spleen, lymph node and liver, scavenger receptor antigen expression was associated specifically with phagocytic cells which had taken up colloidal carbon. To examine macrophage adhesion in a context relevant to the interactions occurring within lymphoid and non‐lymphoid organs, and the contribution of macrophage scavenger receptor to this adhesion, we designed an assay of macrophage adhesion to frozen tissue sections. Adhesion to most tissues was high and uniform in the absence of any chelating agents. The chelation of Ca 2+ and Mg 2+ revealed specific patterns of macrophage adhesion in lymphoid and non‐lymphoid organs which was completely inhibited by 2F8. The ability of this antibody to block the EDTA‐resistant adhesion correlated with tissue expression of the antigen in some tissues. Unlike adhesion to tissue culture‐treated plastic, macrophage scavenger receptor‐dependent adhesion of macrophages to frozen tissue sections did not exhibit an absolute requirement for exogenous fetal bovine serum indicating the presence of an endogenous ligand for scavenger receptor within the tissues. We propose that macrophage scavenger receptor is a candidate homing or retention molecule for macrophage localization within ligand‐rich tissues.
Alkene reactivities in trifluoroacetic acid. A comparison of norbornene and protoadamantene in trifluoroacetic acid and aqueous acid (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkene reactivities in trifluoroacetic acid. A comparison of norbornene and protoadamantene in trifluoroacetic acid and aqueous acidAnnette D. Allen and Thomas T. TidwellCite this: J. Am. Chem. Soc. 1982, 104, 11, 3145–3149Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ja00375a034https://doi.org/10.1021/ja00375a034research-articleACS PublicationsRequest reuse permissionsArticle Views718Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Three-Compartment Model for Contaminant Accumulation by Semipermeable Membrane Devices (1998)

Passive sampling of dissolved hydrophobic contaminants with lipid (triolein)-containing semipermeable membrane devices (SPMDs) has been gaining acceptance for environmental monitoring. Understanding of the accumulation process has employed a simple polymer film-control model of uptake by the polymer-enclosed lipid, while aqueous film control has been only briefly discussed. A more complete three-compartment model incorporating both aqueous film (turbulent-diffusive) and polymer film (diffusive) mass transfer is developed here and is fit to data from accumulation studies conducted in constant-concentration, flow-through dilutors. This model predicts aqueous film control of the whole device for moderate to high Kow compounds, rather than polymer film control. Uptake rates for phenanthrene and 2,2‘,5,5‘-tetrachlorobiphenyl were about 4.8 and 4.2 L/day/standard SPMD, respectively. Maximum 28 day SPMD concentration factors of 30 000 are predicted for solutes with log Kow values of >5.5. Effects of varying aqueous and polymer film thicknesses and solute diffusivities in the polymer film are modeled, and overall accumulation by the whole device is predicted to remain under aqueous film control, although accumulation in the triolein may be subject to polymer film control. The predicted half-life and integrative response of SPMDs to pulsed concentration events is proportional to log KSPMD.
Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease (2015)

The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. In the past year, CHIKV has expanded into the Americas, with approximately 1 million cases reported to date, whereas RRV continues to circulate in the South Pacific. Currently, there is no licensed specific treatment for alphavirus disease, and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. Pentosan polysulfate (PPS) is a glycan derivative that is orally bioavailable, has few toxic side effects, and is currently licensed under the name Elmiron for the treatment of cystitis in the United States. Our findings show that RRV infection damages the articular cartilage, including a loss of proteoglycans within the joint. Furthermore, treatment with PPS reduced the severity of both RRV- and CHIKV-induced musculoskeletal disease, including a reduction in inflammation and joint swelling, suggesting that PPS is a promising candidate for drug repurposing for the treatment of alphavirus-induced arthritis.
Signaling System No. 7 (SS7/C7): Protocol, Architecture, and Applications (2003)

A complete, practical guide to the world's most popular signaling system, including SIGTRAN, GSM-MAP, and Intelligent Networks. Provides in-depth coverage of the SS7 protocols, including implementation details Covers SS7 over IP (SIGTRAN) using real-world examples Covers SS7/C7 from both a North American and European perspective, providing a broad international understanding of the technology and associated standards Explains mobile wireless concepts and signaling, including mobile application part (MAP) Provides a thorough explanation of the Intelligent Network (IN) and associated protocols (INAP/AIN)Signaling System No. 7 (SS7) is a signaling network and protocol that is used globally to bring telecommunications networks, both fixed-line and cellular, to life. SS7 has numerous applications and is at the very heart of telecommunications. Setting up phone calls, providing cellular roaming and messaging, and supplying converged voice and data services are only a few of the ways that SS7 is used in the communications network. SS7 also provides the point of interconnection between converging voice and data networks. This transition, which affects everyone who works with the data network, has bolstered the need for practical and applied information on SS7. In short, anyone who is interested in telecommunications should have a solid understanding of SS7.Signaling System No. 7 (SS7/C7): Protocol, Architecture, and Services will help you understand SS7 from several perspectives. It examines the framework and architecture of SS7, as well as how it is used to provide today's telecommunications services. It also examines each level of the SS7 protocol-all the way down to the bit level of messages. In addition, the SIGTRAN standards are discussed in detail, showing the migration from SS7 to IP and explaining how SS7 information is transported over IP.
Faster arbitrary-precision dot product and matrix multiplication (2019)

We present algorithms for real and complex dot product and matrix multiplication in arbitrary-precision floating-point and ball arithmetic. A low-overhead dot product is implemented on the level of GMP limb arrays; it is about twice as fast as previous code in MPFR and Arb at precision up to several hundred bits. Up to 128 bits, it is 3-4 times as fast, costing 20-30 cycles per term for floating-point evaluation and 40-50 cycles per term for balls. We handle large matrix multiplications even more efficiently via blocks of scaled integer matrices. The new methods are implemented in Arb and significantly speed up polynomial operations and linear algebra.
A machine learning approach for indirect human presence detection using IOT devices (2016)

This paper describes the construction of a system that uses information from several home automation devices, to detect the presence of a person in the space where the devices are located. The detection however doesn't rely on the information of devices that explicitly detect human presence, like motion detectors or smart cameras. The information used is the one available in the Muzzley system, which is a mobile application that allows the monitoring and control of several types of devices from a single program. The provided information was anonymized at the source. The first step was to extract adequate features for this problem. A labeling step is introduced using a combination of heuristics to assert the likelihood of anyone being home at a given time, based on all information available, including, but not limited to, direct presence detectors. The solution rests mainly on the use of supervised learning algorithms to train models that detect the presence without any information based on direct presence detectors. The model should be able to detect patterns of usage when the owner is at home rather than rely only on direct sensors. Results show that detection in this context is difficult, but we believe these results shed some light on possible paths to improve the system's accuracy.
Reconstruction of biomedical images and sparse stochastic modeling (2012)

We propose a novel statistical formulation of the image-reconstruction problem from noisy linear measurements. We derive an extended family of MAP estimators based on the theory of continuous-domain sparse stochastic processes. We highlight the crucial roles of the whitening operator and of the Lévy exponent of the innovations which controls the sparsity of the model. While our family of estimators includes the traditional methods of Tikhonov and total-variation (TV) regularization as particular cases, it opens the door to a much broader class of potential functions (associated with infinitely divisible priors) that are inherently sparse and typically nonconvex. We also provide an algorithmic scheme - naturally suggested by our framework - that can handle arbitrary potential functions. Further, we consider the reconstruction of simulated MRI data and illustrate that the designed estimators can bring significant improvement in reconstruction performance.
Copolymerization of Ethylene with Vinyl Acetate by Trialkylaluminum-Lewis Base-Peroxide Catalyst (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopolymerization of Ethylene with Vinyl Acetate by Trialkylaluminum-Lewis Base-Peroxide CatalystTadao Yatsu, Shuji Moriuchi, and Hiroyasu FujiiCite this: Macromolecules 1977, 10, 2, 249–253Publication Date (Print):March 1, 1977Publication History Published online1 May 2002Published inissue 1 March 1977https://pubs.acs.org/doi/10.1021/ma60056a007https://doi.org/10.1021/ma60056a007research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome (2014)

Cardio-facio-cutaneous (CFC) syndrome is one of the 'RASopathies', a group of phenotypically overlapping syndromes caused by germline mutations that encode components of the RAS-MAPK pathway. Germline mutations in BRAF cause CFC syndrome, which is characterized by heart defects, distinctive facial features and ectodermal abnormalities. To define the pathogenesis and to develop a potential therapeutic approach in CFC syndrome, we here generated new knockin mice (here Braf(Q241R/+)) expressing the Braf Q241R mutation, which corresponds to the most frequent mutation in CFC syndrome, Q257R. Braf(Q241R/+) mice manifested embryonic/neonatal lethality, showing liver necrosis, edema and craniofacial abnormalities. Histological analysis revealed multiple heart defects, including cardiomegaly, enlarged cardiac valves, ventricular noncompaction and ventricular septal defects. Braf(Q241R/+) embryos also showed massively distended jugular lymphatic sacs and subcutaneous lymphatic vessels, demonstrating lymphatic defects in RASopathy knockin mice for the first time. Prenatal treatment with a MEK inhibitor, PD0325901, rescued the embryonic lethality with amelioration of craniofacial abnormalities and edema in Braf(Q241R/+) embryos. Unexpectedly, one surviving pup was obtained after treatment with a histone 3 demethylase inhibitor, GSK-J4, or NCDM-32b. Combination treatment with PD0325901 and GSK-J4 further increased the rescue from embryonic lethality, ameliorating enlarged cardiac valves. These results suggest that our new Braf knockin mice recapitulate major features of RASopathies and that epigenetic modulation as well as the inhibition of the ERK pathway will be a potential therapeutic strategy for the treatment of CFC syndrome.