gebhart/patrepeval huggingface dataset:
An experimental validation of a statistical based damage detection approach (2010)

In this work, a previously-developed, statistical-based, damage-detection approach was validated for its ability to autonomously detect damage in bridges. The damage-detection approach uses statistical differences in the actual and predicted behavior of the bridge caused under a subset of ambient trucks. The predicted behavior is derived from a statistics-based model trained with field data from the undamaged bridge (not a finite element model). The differences between actual and predicted responses, called residuals, are then used to construct control charts, which compare undamaged and damaged structure data. Validation of the damage-detection approach was achieved by using sacrificial specimens that were mounted to the bridge and exposed to ambient traffic loads and which simulated actual damage-sensitive locations. Different damage types and levels were introduced to the sacrificial specimens to study the sensitivity and applicability. The damage-detection algorithm was able to identify damage, but it also had a high false-positive rate. An evaluation of the sub-components of the damage-detection methodology and methods was completed for the purpose of improving the approach. Several of the underlying assumptions within the algorithm were being violated, which was the source of the false-positives. Furthermore, the lack of an automatic evaluation process was thought to potentially be an impediment to widespread use. Recommendations for the improvement of the methodology were developed and preliminarily evaluated. These recommendations are believed to improve the efficacy of the damage-detection approach.
The effect of relaxed functional constraints on the photosynthetic gene rbcL in photosynthetic and nonphotosynthetic parasitic plants (1998)

The photosynthetic gene rbcL has been lost or dramatically altered in some lineages of nonphotosynthetic parasitic plants, but the dynamics of these events following loss of photosynthesis and whether rbcL has sustained functionally significant changes in photosynthetic parasitic plants are unknown. To assess the changes to rbcL associated with the loss of functional constraints for photosynthesis, nucleotide sequences from nonparasitic and parasitic plants of Scrophulariales were used for phylogeny reconstruction and character analysis. Plants in this group display a broad range of parasitic abilities, from photosynthetic ("hemiparasites") to nonphotosynthetic ("holoparasites"). With the exception of Conopholis (Orobanchaceae), the rbcL locus is present in all parasitic plants of Scrophulariales examined. Several holoparasitic genera included in this study, including Boschniakia, Epifagus, Orobanche, and Hyobanche, have rbcL pseudogenes. However, the holoparasites Alectra orobanchoides, Harveya capensis, Harveya purpurea, Lathraea clandestina, Orobanche corymbosa, O. fasciculata, and Striga gesnerioides have intact open reading frames (ORFs) for the rbcL gene. Phylogenetic hypotheses based on rbcL are largely in agreement with those based on sequences of the nonphotosynthetic genes rps2 and matK and show a single origin of parasitism, and loss of photosynthesis and pseudogene formation have been independently derived several times in Scrophulariales. The mutations in rbcL in nonparasitic and hemiparasitic plants would result in largely conservative amino acid substitutions, supporting the hypothesis that functional proteins can experience only a limited range of changes, even in minimally photosynthetic plants. In contrast, ORFs in some holoparasites had many previously unobserved missense substitutions at functionally important amino acid residues, suggesting that rbcL genes in these plants have evolved under relaxed or altered functional constraints.
Layered Halide Double Perovskites: Dimensional Reduction of Cs<sub>2</sub>AgBiBr<sub>6</sub> (2018)

We investigate the consequences of dimensional confinement on halide double perovskites by synthesizing two-dimensional analogues of the recently reported three-dimensional double perovskite Cs<sub>2</sub>AgBiBr<sub>6</sub>. The layered perovskites (BA)<sub>4</sub>AgBiBr<sub>8</sub> (1) and (BA)<sub>2</sub>CsAgBiBr<sub>7</sub> (2) (BA = CH<sub>3</sub>(CH<sub>2</sub>)<sub>3</sub>NH<sub>3</sub><sup>+</sup>) feature metal-halide sheets of mono and bilayer thickness, respectively, where the ordered double-perovskite lattice is partitioned by organic cations. Electronic structure calculations indicate that the indirect bandgap of Cs<sub>2</sub>AgBiBr<sub>6</sub> becomes direct when the infinitely thick inorganic lattice is reduced to monolayer thickness. Calculations on model systems allow us to separate the effects of dimensional reduction from those of the accompanying structural distortions in the inorganic sublattice. Detailed optical characterization shows that the photophysical properties of 1 and 2 are markedly different than those of their well-studied lead-halide analogs. Hybrid layered derivatives of double perovskites substantially expand on the substitutional flexibility of halide perovskites to encompass greater compositional and electronic diversity.
Endcapping of high-power 3 µm fiber lasers (2019)

Fiber tip photodegradation through OH diffusion currently limits the long term operation of high-power fiber lasers and amplifiers operating near 3 µm. To address this issue, we investigate the resistance to OH diffusion of fluoride and oxide endcaps manufactured out of ZrF$_4$<sub>4</sub>, AlF$_3$<sub>3</sub>, GeO$_2$<sub>2</sub>, SiO$_2$<sub>2</sub> and Al$_2$<sub>2</sub>O$_3$<sub>3</sub> fibers. To this extent, the endcaps are spliced at the output of a 20 W continuous-wave fiber laser operating at 2.8 µm and their degradation over a 100 h time period is monitored. While the fluoride-based endcaps underwent failure during the first 10 h, their oxide counterparts survived the experiment, although showcasing degradation which was reflected as an increase of the endface temperature over time. To overcome this issue, we propose a novel method to completely suppress OH diffusion which consists in sputtering a nanoscopic diffusion barrier film made of silicon nitride (Si$_3$<sub>3</sub>N$_4$<sub>4</sub>) on the output face of the endcap. The effectiveness of the approach is validated on Al$_2$<sub>2</sub>O$_3$<sub>3</sub>, ZrF$_4$<sub>4</sub> and AlF$_3$<sub>3</sub> endcaps which show no sign of degradation after being used for more than a 100 h at the output of a 3 µm high-power fiber laser.
Cognitive task analysis, interface design, and technical troubleshooting (1993)

We propose a model of interface design that makes use of two interdependent levels of cognitive analysis: 1) the study of the criterion task through an analysis of expert/novice differences and; 2) the application of a GOMS analysis to a working interface design. We review this dual analysis in the context of HYDRIVE, a video-disc based intelligent tutoring system designed to facilitate the development of troubleshooting skills for aircraft hydraulics systems. The initial cognitive task analysis enabled the identification of criticat troubleshooting skills and troubleshooting procedures. We find, though, that even with an in-depth initial cognitive task analysis, the GOMS interface analysis resulted in significant and beneficial design changes.
Benz-amidinato calcium iodide catalyzed aldehyde and ketone hydroboration with unprecedented functional group tolerance (2017)

A benz-amidinato calcium compound, [PhC(NiPr)<sub>2</sub>CaI] (1), catalyzed hydroboration of a wide range of aldehydes and ketones using pinacolborane (HBpin) at room temperature is reported. The catalyst shows functional group tolerance even towards OH and NH groups. The strategy was further extended to imines.
Detection of autoimmune cells proliferating to myelin basic protein and selection of T cell lines that mediate experimental autoimmune encephalomyelitis (EAE) in mice. (1983)

A procedure is described for the detection of an in vitro proliferative response to the autologous mouse myelin basic protein in mice injected with mouse spinal cord homogenate (MSCH) or with myelin basic proteins (BP) of mouse (MBP) or rat (RBP) origin. The administration of MSCH, but not of MBP or RBP, in a suitable adjuvant could produce a reproducible clinical disease. Nevertheless, a proliferative response to the autologous MBP could not be detected after either inoculation. Only the removal of the adherent cell fraction from the immunized cell population and its replacement with fresh naive accessory cells could reveal a proliferative response to the autologous MBP and to the heterologous RBP. A heteroclitic cross-reactivity between MBP and RBP is demonstrated. The possibility of detecting an in vitro proliferative response to BP allowed the selection and propagation in vitro of cells specific to BP. T cell lines were established that specifically proliferated in response to BP and mediated EAE in normal mice. Intravenous inoculation of as few as 10(6) line cells was capable of producing clinical signs of EAE in normal recipients within 5 to 6 days. Thus, although an inoculation of MSCH was required for active induction of the disease, T cells specifically reactive against BP are sufficient for mediation of EAE in mice.
Novel dual Marx Generator for microplasma applications (2005)

Micrometer size plasmas, or microplasmas, find applications in pollution control, reduction, and prevention. The required nonthermal plasmas can be generated by either an electron beam or an electric discharge. The pulse widths and voltages necessary to generate these nonthermal plasmas are 10/sup -10/-10/sup -8/ s, and 10/sup 3/-10/sup 4/ V, respectively, depending on the application. The required energy is typically in the low 10/sup -3/ J range. This paper presents a novel circuit design to generate high-voltage pulses with variable pulse widths and pulse rise and fall times in the low 10/sup -9/ s regime. The circuit employs two parallel Marx Generators utilizing bipolar junction transistors (BJTs) as closing switches. The BJTs are operated in the avalanche mode to yield fast rise times. The design allows for positive or negative polarity pulses, and can easily be changed to yield higher or lower output voltage.
Highly efficient high temperature electrolysis (2008)

High temperature electrolysis of water and steam may provide an efficient, cost effective and environmentally friendly production of H2 using electricity produced from sustainable, non-fossil energy sources. To achieve cost competitive electrolysis cells that are both high performing i.e. minimum internal resistance of the cell, and long-term stable, it is critical to develop electrode materials that are optimal for steam electrolysis. In this article electrolysis cells for electrolysis of water or steam at temperatures above 200 °C for production of H2 are reviewed. High temperature electrolysis is favourable from a thermodynamic point of view, because a part of the required energy can be supplied as thermal heat, and the activation barrier is lowered increasing the H2 production rate. Only two types of cells operating at high temperature (above 200 °C) have been described in the literature, namely alkaline electrolysis cells (AEC) and solid oxide electrolysis cells (SOEC). In the present review emphasis is on state-of-the art electrode materials and development of new materials for SOECs. Based on the state-of-the-art performance for SOECs H2 production by high temperature steam electrolysis using SOECs is competitive to H2 production from fossil fuels at electricity prices below 0.02–0.03 € per kWh. Though promising SOEC results on H2 production have been reported a substantial R&D is still required to obtain inexpensive, high performing and long-term stable electrolysis cells.
Fast K-Means Clustering with Anderson Acceleration (2018)

We propose a novel method to accelerate Lloyd's algorithm for K-Means clustering. Unlike previous acceleration approaches that reduce computational cost per iterations or improve initialization, our approach is focused on reducing the number of iterations required for convergence. This is achieved by treating the assignment step and the update step of Lloyd's algorithm as a fixed-point iteration, and applying Anderson acceleration, a well-established technique for accelerating fixed-point solvers. Classical Anderson acceleration utilizes m previous iterates to find an accelerated iterate, and its performance on K-Means clustering can be sensitive to choice of m and the distribution of samples. We propose a new strategy to dynamically adjust the value of m, which achieves robust and consistent speedups across different problem instances. Our method complements existing acceleration techniques, and can be combined with them to achieve state-of-the-art performance. We perform extensive experiments to evaluate the performance of the proposed method, where it outperforms other algorithms in 106 out of 120 test cases, and the mean decrease ratio of computational time is more than 33%.
IGES and PDES, the current status of product data exchange standard (2003)

Currently, IGES (Initial Graphic Exchange Specification) is the international standard for exchange product definition data between CAD (computer-aided design) systems. However, due to its efficiencies, a new standard is in the process of development and will gradually replace IGES. It is believed that PDES will be less error-prone than IGES. Its improvements include free-form format representation of objects, a three-level database architecture, and reduced memory and time requirements. Future IGES developments will be suspended when PDES is introduced to general use. But though PDES will contain all functions of IGES, IGES will remain in use for some time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Testing decisions in the pandemic: how do we use imperfect tests for COVID-19 (SARS-CoV-2) to make clinical decisions? (2020)

This is the second article of a series on how to use diagnostic test accuracy evidence. In this article, we explain how diagnostic test accuracy estimates may be applied in clinical practice, using the example of coronavirus disease 2019 (COVID-19). Using clinical scenarios, we guide the reader through the process of applying estimates of diagnostic accuracy to change the pre-test probability of disease, and make clinical decisions about their patient.
Real‐time adaptive sequential design for optimal acquisition of arterial spin labeling MRI data (2010)

An optimal sampling schedule strategy based on the Fisher information matrix and the D-optimality criterion has previously been proposed as a formal framework for optimizing inversion time scheduling for multi-inversion-time arterial spin labeling experiments. Optimal sampling schedule possesses the primary advantage of improving parameter estimation precision but requires a priori estimation of plausible parameter distributions that may not be available in all situations. An adaptive sequential design approach addresses this issue by incorporating the optimal sampling schedule strategy into an adaptive process that iteratively updates the parameter estimates and adjusts the optimal sampling schedule accordingly as data are acquired. In this study, the adaptive sequential design method was experimentally implemented with a real-time feedback scheme on a clinical MRI scanner and was tested in six normal volunteers. Adapted schedules were found to accommodate the intrinsically prolonged arterial transit times in the occipital lobe of the brain. Simulation of applying the adaptive sequential design approach on subjects with pathologically reduced perfusion was also implemented. Simulation results show that the adaptive sequential design approach is capable of incorporating pathologic parameter information into an optimal arterial spin labeling scheduling design within a clinically useful experimental time.
Asymmetric Hydrogenation of Bicyclic Ketones Catalyzed by BINAP/IPHAN−Ru(II) Complex (2010)

Hydrogenation of 3-quinuclidinone and bicyclo[2.2.2]octan-2-one with a combined catalyst system of RuCl(2)[(S)-binap][(R)-iphan] and t-C(4)H(9)OK in 2-propanol afforded the chiral alcohols in 97-98% ee. 2-Diphenylmethyl-3-quinuclidinone was hydrogenated with the same catalyst to the cis alcohol with perfect diastereo- and enantioselectivity. The reaction of unsymmetrical ketones with a bicyclo[2.2.1] or -[2.2.2] skeleton gave the corresponding alcohols with high stereoselectivity.
<title>Image sequence processing for videowall visualization</title> (2000)

A new processing scheme for large high-resolution displays such as Videowalls is proposed in this paper. The scheme consists in a deinterlacing, an interpolation and an optional enhancement algorithm; its hardware implementation requires a low computational cost. The deinterlacing algorithm is motion- adaptive. A simple hierarchical three-level motion detector provides indications of static, slow and fast motion to activate a temporal FIR filter, a three-tap vertico-temporal median operator and a spatial FIR filter respectively. This simple algorithm limits the hardware requirements to three field memories plus a very reduced number of algebraic operations per interpolated pixel. Usually linear techniques such as pixel repetition or the bilinear method are employed for image interpolation, which however either introduce artifacts (e.g. blocking effects) or tend to smooth edges. A higher quality rendition of the image is obtained by the concept of the Warped Distance among the pixels of an image. The computational load of the proposed approach is very small if compared to that of state-of-the-art nonlinear interpolation operators. Finally the contrast enhancement algorithm is a modified Unsharp Masking technique: a polynomial function is added to modulate the sharpening signal, which allows to discriminate between noise and signal and, at the same time, provides an appropriate amplification to low-contrast image details.
Moveable interactive projected displays using projector based tracking (2005)

Video projectors have typically been used to display images on surfaces whose geometric relationship to the projector remains constant, such as walls or pre-calibrated surfaces. In this paper, we present a technique for projecting content onto moveable surfaces that adapts to the motion and location of the surface to simulate an active display. This is accomplished using a projector based location tracking techinque. We use light sensors embedded into the moveable surface and project low-perceptibility Gray-coded patterns to first discover the sensor locations, and then incrementally track them at interactive rates. We describe how to reduce the perceptibility of tracking patterns, achieve interactive tracking rates, use motion modeling to improve tracking performance, and respond to sensor occlusions. A group of tracked sensors can define quadrangles for simulating moveable displays while single sensors can be used as control inputs. By unifying the tracking and display technology into a single mechanism, we can substantially reduce the cost and complexity of implementing applications that combine motion tracking and projected imagery.
Analysis and Correlation of Application I/O Performance and System-Wide I/O Activity (2017)

Storage resources in high-performance computing are shared across all user applications. Consequently, storage performance can vary markedly, depending not only on an application's workload but also on what other activity is concurrently running across the system. This variability in storage performance is directly reflected in overall execution time variability, thus confounding efforts to predict job performance for scheduling or capacity planning. I/O variability also complicates the seemingly straightforward process of performance measurement when evaluating application optimizations. In this work we present a methodology to measure I/O contention with more rigor than in prior work. We apply statistical techniques to gain insight from application-level statistics and storage-side logging. We examine different correlation metrics for relating system workload to job I/O performance and identify an effective and generally applicable metric for measuring job I/O performance. We further demonstrate that the system-wide monitoring granularity can directly affect the strength of correlation observed. Insufficient granularity and measurements can hide the correlations between application I/O performance and system-wide I/O activity.
The Serine Protease Inhibitors TLCK and TPCK React with the RB-Binding Core of HPV-18 E7 Protein and Abolish Its RB-Binding Capability (1996)

The human papillomaviruses associated with cervical cancer (e.g., HPV-16 and HPV-18) express an E7 oncoprotein which mediates the immortalization of primary genital keratinocytes and the transformation of rodent cells. The 105-amino-acid HPV-18 E7 protein contains two zinc fingers as well as a conserved amino-terminal motif (Rb-binding core) which binds and alters the interactions of the retinoblastoma susceptibility gene product (Rb). We report here that two serine protease inhibitors, tosyl-L-lysine chloromethyl ketone (TLCK) and tosyl-L-phenylalanine chloromethyl ketone (TPCK), reacted with and generated an altered form of the HPV-18 E7 protein. Chemical modification of the E7 protein was initially observed during its extraction and immunoprecipitation from mammalian cells but could also be detected using E7 protein expressed in vitro by reticulocyte lysates. More importantly, TLCK and TPCK were able to modify E7 protein in live keratinocytes following their addition to the culture medium. Site-specific mutagenesis demonstrated that the E7 Rb-binding core (Leu-X-Cys-X-Glu) contained a cysteine residue which was essential for this modification and that the TLCK/TPCK-dependent alteration of the E7 protein abolished its ability to bind Rb. These studies indicate that the E7 protein can be inactivated by a specific class of protease inhibitors and that such reagents may be useful for pharmacologically regulating E7 function in vivo. In addition, these results demonstrate that care must be taken when applying these commonly used protease inhibitors in experiments evaluating E7/cellular protein interactions.
20-km distributed temperature sensor based on spontaneous Brillouin scattering (2000)

We report on a novel experimental setup for distributed measurement of temperature, based on spontaneous Brillouin scattering in optical fiber. We have developed a mode-locked Brillouin fiber ring laser in order to generate the dual frequency source required for a heterodyne detection of the backscattered signal. This relatively simple system enables temperature measurements over 20 km with a spatial resolution of 7 m.
Influence of polymerization conditions on microstructure of norbornene-ethylene copolymers made using metallocene catalysts and MAO (1997)

When characterized with 13C-NMR, it was found that norbornene-ethylene copolymers had a more complicated microstructure when dimethylsilyl bis(indenyl) zirconium dichloride was used as the catalyst compared to ethylene bis(indenyl) zirconium dichloride. One could see more block sequences but less alternating sequences. For both catalysts the highest amounts of block sequences were obtained for high norbornene concentrations, medium to high Al/Zr ratios, and low polymerization temperatures. There were also more alternating sequences for high norbornene concentrations and high polymerization temperatures. The isolated norbornene units (separated by more than one ethylene unit) were all exoconfiguration. No unsaturation was seen. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 63: 1071–1076, 1997