gebhart/patrepeval huggingface dataset:
Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer (2007)

Conditionally replicating oncolytic adenoviruses represent a promising developmental strategy for the treatment of cancer refractory to current treatments, such as hormone refractory metastatic breast cancer. In clinical cancer trials, adenoviral agents have been well tolerated, but gene transfer has been insufficient for clinical benefit. One of the main reasons may be the deficiency of the primary adenovirus receptor, and therefore viral capsid modifications have been employed. Another obstacle to systemic delivery is rapid clearance of virus by hepatic Kupffer cells and subsequent inadequate bioavailability. In this study, we compared several capsid-modified oncolytic adenoviruses for the treatment of breast cancer with and without Kupffer cell inactivation. Replication deficient capsid-modified viruses were analyzed for their gene transfer efficacy in vitro in breast cancer cell lines and clinical samples and in vivo in orthotopic models of breast cancer. The effect of Kupffer cell depleting agents on gene transfer efficacy in vivo was evaluated. An aggressive lung metastatic model was developed to study the effect of capsid-modified oncolytic adenoviruses on survival. Capsid-modified viruses displayed increased gene transfer and cancer cell killing in vitro and resulted in increased survival in an orthotopic model of lung metastatic breast cancer in mice. Biodistribution of viruses was favorable, tumor burden and treatment response could be monitored repeatedly. Kuppfer cell inactivation led to enhanced systemic gene delivery, but did not increase the survival of mice. These results facilitate clinical translation of oncolytic adenoviruses for the treatment of hormone refractory metastatic breast cancer.
Nanoengineered Stent Surface to Reduce In-Stent Restenosis <i>in Vivo</i> (2017)

In-stent restenosis (ISR) is the leading cause of stent failure and is a direct result of a dysfunctional vascular endothelium and subsequent overgrowth of vascular smooth muscle tissue. TiO<sub>2</sub> nanotubular (NT) arrays have been shown to affect vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs) in vitro by accelerating VEC cell proliferation and migration while suppressing VSMCs. This study investigates for the first time the potentially beneficial effects of TiO<sub>2</sub> NT arrays on vascular tissue in vivo. TiO<sub>2</sub> NT arrays (NT diameter: 90 ± 5 nm, height: 1800 ± 300 nm) were grown on the surface of titanium stents and characterized in terms of surface morphology and stability. Stents were implanted into the iliofemoral artery using an overinflation model (rabbit). After 28 days, stenosis rates were determined. The data show a statistically significant reduction of stenosis by 30% compared to the control. Tissue in the presence of TiO<sub>2</sub> NTs appears more mature, and less neointima is present between struts. In addition, the extra cellular matrix secreted by cells at the interface of the NT arrays shows complete integration into the nanostructured surface. These results document the accelerated restoration of a functional endothelium in the presence of TiO<sub>2</sub> NT arrays and substantiate their beneficial impact on vascular tissue in vivo. Our findings suggest that TiO<sub>2</sub> NT arrays can be used as a drug-free approach for keeping stents patent long-term and have the potential to address ISR.
Regulation of pyruvate dehydrogenase kinase activity by protein thiol-disulfide exchange. (1982)

Endogenous kinase activity of highly purified pyruvate dehydrogenase complex from bovine kidney is markedly inhibited by N-ethylmaleimide and by certain disulfides. Inhibition by disulfides is highly specific and is reversed by thiols. 5,5'-Dithiobis(2-nitrobenzoate) is the most potent inhibitor, showing significant inhibition at a concentration as low as 1 microM. Cystamine, oxidized glutathione, pantethine, lipoic acid, lipoamide, ergothionine, insulin, oxytocin, and vasopressin were ineffective. Hydrogen peroxide and t-butyl hydroperoxide were inactive. The data indicate pyruvate dehydrogenase kinase (EC 2.7.1.99) contains a thiol group (or groups) that is involved in maintaining a conformation of the enzyme that facilitates phosphorylation and inactivation of its protein substrate, pyruvate dehydrogenase (EC 1.2.4.1). These findings suggest that modulation of pyruvate dehydrogenase kinase activity by thiol-disulfide exchange may be an important physiological mechanism for regulation of kinase activity and, hence, activity of the pyruvate dehydrogenase complex.
AlN and GaN layers deposited on sapphire or silicon substrates: theory and experiment (2002)

As the operating frequencies of telecommunication systems increase, surface acoustic wave (SAW) devices would benefit from the propagation on "high velocity" substrates such as sapphire or [100] silicon. However, the excitation of SAW on such materials requires additional piezoelectric layers, such as AlN or GaN, deposited atop their surface. This paper reports on first theoretical and experimental results with such material combinations.
Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus (1990)

The multidrug resistance (mdr) gene family has been shown to encode a membrane glycoprotein, termed the P-glycoprotein, which functions as a drug efflux pump with broad substrate specificity. This multigene family is expressed in a tissue-specific fashion in a wide variety of normal and neoplastic tissues. The regulation of mdr gene expression in normal tissues is not understood. We have recently shown that mdr mRNA and the P-glycoprotein increases dramatically in the secretory luminal and glandular epithelium of the gravid murine uterus. This observation has suggested that mdr gene expression in the uterus is controlled by the physiologic changes associated with pregnancy. This report now demonstrates that mdr mRNA and P-glycoprotein are induced at high levels in the uterine secretory epithelium by the combination of estrogen and progesterone, the major steroid hormones of pregnancy. This regulation of mdr gene expression in the uterus does not require any other contribution from the fetus or placenta. The data indicate that this gene locus is hormonally responsive to estrogen and progesterone in the uterine secretory epithelium, suggesting an important and physiologically regulated role during pregnancy.
ENTRE O SAGRADO E O PROFANO: NOTAS DE CULTURA PORTUGUESA (2017)

A cultura portuguesa, entre outros aspetos, é fortemente marcada pelo período da expansão marítima e pela construção do império colonial, toda uma época em que a simbiose profanoreligiosa se manifesta em todo o seu esplendor civilizacional bem patente no património material e imaterial de influência lusa espalhado pelo mundo. Fruto de uma estratégia que encontra as primeiras decisões estruturantes no início do século XIV com D. Dinis, o sucesso imperial português foi vítima da sua própria grandeza e dessa relação umbilical entre a Igreja e o poder político cujos pecados seriam fatais e facilitariam um rápido declínio já no século XVI, cujas causas e consequências foram apontadas por vozes contemporâneas. As marcas culturais portuguesas sobreviveram ao império e encontram a sua melhor expressão no Brasil, exemplo máximo de uma expressão cultural construída de sagrado e de profano.
Prospective Study of Sunburn and Sun Behavior Patterns During Adolescence (2012)

With at least 50% of children experiencing sunburns before age 11 and again 3 years later, targeting children in pediatric offices and community settings regarding unprotected UV exposure may be a practical approach. Because periadolescence is a time of volatility with regard to sun behaviors, learning more about children who receive sunburns versus those who avoid them is a critical research task.
Ultra-compact optical true time delay device for wideband phased array radars (2010)

An ultra-compact optical true time delay device is demonstrated that can support 112 antenna elements with better than six bits of delay in a volume 16"×5"×4" including the box and electronics. Free-space beams circulate in a White cell, overlapping in space to minimize volume. The 18 mirrors are slow-tool diamond turned on two substrates, one at each end, to streamline alignment. Pointing accuracy of better than 10μrad is achieved, with surface roughness ~45 nm rms. A MEMS tip-style mirror array selects among the paths for each beam independently, requiring ~100 μs to switch the whole array. The micromirrors have 1.4° tip angle and three stable states (east, west, and flat). The input is a fiber-and-microlens array, whose output spots are re-imaged multiple times in the White cell, striking a different area of the single MEMS chip in each of 10 bounces. The output is converted to RF by an integrated InP wideband optical combiner detector array. Delays were accurate to within 4% (shortest delay) to 0.03% (longest mirror train). The fiber-to-detector insertion loss is 7.82 dB for the shortest delay path.
Chemical sputtering of nickel oxide and carbide by low energy (5–200 eV) C+ and O+ beams (1987)

Recombination of carbon and oxygen on a Ni(111) surface has been studied by low energy (5–200 eV) reactive ion bombardment (RIB). The reactions O++NiC(s) and C++NiO(s) both result in efficient removal of the surface carbon and oxygen, respectively. Removal of the adspecies occurs most efficiently at low kinetic energies and the rate of sputtering decreases with increasing kinetic energy. Energy dissipation into the solid appears to be insufficient for stabilization of the molecular CO product as a surface adsorbate.
The use of scalp hypothermia in the prevention of doxorubicin-induced hair loss (1984)

A randomized clinical trial was performed to determine the effectiveness of scalp hypothermia in the prevention of hair loss associated with doxorubicin. Twenty-six patients were randomized to receive scalp hypothermia or chemotherapy alone. Data were analyzed on 25 patients: 12 in the treatment group and 13 in the control group. There was acceptable hair preservation in 75% of the patients who received the scalp hypothermia; only 8% of the patients in the control group had acceptable hair preservation (P = 0.0009). The data were further broken down into patients receiving low-dose doxorubicin and high-dose doxorubicin. Side effects were minimal. The results support the use of scalp hypothermia in reducing doxorubicin-induced alopecia.
The efficient export of NADP‐containing glucose‐fructose oxidoreductase to the periplasm of <i>Zymomonas mobilis</i> depends both on an intact twin‐arginine motif in the signal peptide and on the generation of a structural export signal induced by cofactor binding (1999)

The periplasmic, NADP-containing glucose-fructose oxidoreductase of the gram-negative bacterium Zymomonas mobilis belongs to a class of redox cofactor-dependent enzymes which are exported with the aid of a signal peptide containing a so-called twin-arginine motif. In this paper we show that the replacement of one or both arginine residues results in drastically reduced translocation of glucose-fructose oxidoreductase to the periplasm, showing that this motif is essential. Mutant proteins which, in contrast to wild-type glucose-fructose oxidoreductase, bind NADP in a looser and dissociable manner, were severely affected in the kinetics of plasma membrane translocation. These results strongly suggest that the translocation of glucose-fructose oxidoreductase into the periplasm uses a Sec-independent apparatus which recognizes, as an additional signal, a conformational change in the structure of the protein, most likely triggered by cofactor binding. Furthermore, these results suggest that glucose-fructose oxidoreductase is exported in a folded form. A glucose-fructose oxidoreductase:beta-galactosidase fusion protein is not lethal to Z. mobilis cells and leads to the accumulation of the cytosolic preform of wild-type glucose-fructose oxidoreductase expressed in trans but not of a typical Sec-substrate (OmpA), indicating that the glucose-fructose oxidoreductase translocation apparatus can be blocked without interfering with the export of essential proteins via the Sec pathway.
MapReduce scheduling in hybrid cloud with multi-level privacy (2015)

MapReduce is a popular programming model for analyzing large datasets. It allows for parallel processing of large amounts of data over commodity computers or cloud computing resources. Hadoop is an open-source implementation of MapReduce and uses the Capacity or Fair scheduler to assign map and reduce tasks to the various computing nodes. They both address fair share of resources between the users but do not consider any privacy constraint, an important concern when using cloud resources due to clouds generally having a different risk of exposure. Jobs are currently sent to cloud resources disregarding the different privacy implementations of each cloud involved. This paper suggest a multi-level privacy scheduler with data clearance levels and cloud authorization levels so the mapping of map and reduce tasks to cloud resources can satisfy the organization's privacy constraints.
Fully integrated triple-mode sigma-delta modulator for speech codec (2016)

Mixed-signal speech processing system has been used in microphone-embedded portable electronics. Speech codec is the core of such a system. In speech codecs, sigma-delta modulator is one key block which converts analog voice signal into pulse density modulation (PDM) output for further digital signal processing. This paper shows the design of a triple-mode switched-capacitor sigma-delta modulator for speech codec. High mode (20 kHz signal bandwidth), low mode (4 kHz signal bandwidth), and sleep mode are implemented by addressing a flexible operation current. In order to realize a fully integrated solution, power management circuits dedicated to the modulator are also implemented, which includes frequency detector, LDO, bandgap and reference voltage buffers. The ASIC is fabricated in a 0.18-um CMOS process. In high mode measurement, an A-weighted signal-to-noise ratio (SNR) of 78 dB with -2.5 dBFS input is achieved under 138 uA. In low mode measurement, an SNR of 78 dB with -2 dBFS is achieved under 100 uA. In the standby condition, a sleep mode with current less than 10 uA is realized, so that the battery life is extended.
Adjuvant Immunotherapy With Tumor Infiltrating Lymphocytes and Interleukin-2 in Patients With Resected Stage III and IV Melanoma (2003)

Adoptive immunotherapy with tumor infiltrating lymphocytes (TIL) and interleukin (IL)-2 is reasonably effective in the treatment of patients with advanced melanoma. However, theoretically it should be of greater benefit as adjuvant therapy, especially in high-risk stages (resected stages III and IV). In a preliminary study, 25 patients (aged 23-72 years) with stage III-IV melanoma who underwent resection of metachronous metastases were reinfused with TIL cultivated and expanded in vitro with IL-2 from surgically removed metastases. IL-2 (starting dose 12 x 10 IU/m ) was co-administered as a continuous infusion according to West's scheme. A total of 8/22 (36.3%) evaluable patients were disease-free (DF) at a median follow-up of 5 years. DF survival (DFS) and overall survival (OS) rates were 44% and 37%, respectively, at 2 years, and 52% and 45% at 3 years. The CNS was the only site of disease recurrence in 57% of patients who relapsed. DF patients received a higher median dose of IL-2 than those who progressed (total dose 110 x 10 versus 86 x 10 IU/m, respectively). The progressive reduction in IL-2 dosage allowed all patients to complete treatment without permanent grade 4 toxicity. Analysis of tumor immunosuppression factors in lymphocytes inside the tumor (TCR zeta and epsilon chains, p56, FAS, and FAS-ligand) confirmed that the immunologic potential of TIL, depressed at the time of metastasectomy, was significantly restored after in vitro culture with IL-2. Adoptive immunotherapy with TIL and IL-2 could improve DFS and OS, although further work is required to determine its role in the treatment of patients with high-risk melanoma.
UAV relay network to support WSN connectivity (2010)

An important problem in Wireless Sensor Networks (WSN) is the occurrence of failures that lead to the disconnection of parts of the network, compromising the final results achieved by the WSN operation. A way to overcome such problem is to provide a reliable connection to support the connectivity via other types of nodes that communicate with the sensor nodes. This paper proposes the usage of a network composed by Unmanned Aerial Vehicles (UAVs) as a relay network to guarantee the delivery of data produced by WSN nodes on the ground to the users. Results from simulations of the proposed technique are provided and discussed.
De-identifying government datasets: (2023)

De-identification is a general term for any process of removing the association between a set of identifying data and the data subject. This document describes the use of de-identification with the goal of preventing or limiting disclosure risks to individuals and establishments while still allowing for the production of meaningful statistical analysis. Government agencies can use de-identification to reduce the privacy risk associated with collecting, processing, archiving, distributing, or publishing government data. Previously, NIST IR 8053, De-Identification of Personal Information, provided a detailed survey of de-identification and re-identification techniques. This document provides specific guidance to government agencies that wish to use de-identification. Before using de-identification, agencies should evaluate their goals for using de-identification and the potential risks that releasing de-identified data might create. Agencies should decide upon a data-sharing model, such as publishing de-identified data, publishing synthetic data based on identified data, providing a query interface that incorporates de-identification, or sharing data in non-public protected enclaves. Agencies can create a Disclosure Review Board to oversee the process of de-identification. They can also adopt a de-identification standard with measurable performance levels and perform re-identification studies to gauge the risk associated with de-identification. Several specific techniques for de-identification are available, including de-identification by removing identifiers, transforming quasi-identifiers, and generating synthetic data using models. People who perform de-identification generally use special-purpose software tools to perform the data manipulation and calculate the likely risk of re-identification. However, not all tools that merely mask personal information provide sufficient functionality for performing de-identification. This document also includes an extensive list of references, a glossary, and a list of specific de-identification tools, which is only included to convey the range of tools currently available and is not intended to imply a recommendation or endorsement by NIST.
A 20-90 MHz 26-channel cochlear-based channelizer (2010)

This paper presents a 26-channel channelizer based on the mammalian cochlea and covering the 20-90 MHz band. Each channel has a 6-pole frequency response with a constant absolute bandwidth of 1.40 MHz at 20-35 MHz, and a constant fractional bandwidth of 4.5% at 35-90 MHz, and is built entirely using lumped elements. Measurements show an S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> <; -12 dB at 20-90 MHz, a loss of 4-7 dB, > 40 dB isolation between the channels, and agree well with simulations. The applications areas are in communication systems with very high levels of interferes and in defense systems.
El interés como fuerza motivacional, una metodología para el control en la Educación Física (2006)

El trabajo nos muestra los resultados de una larga investigacion realizada en varios municipios cubanos, sobre el interes que presentan los alumnos del segundo ciclo primario por la educacion fisica ademas, nos propone algunos instrumentos que cualquier especialista en dicha asignatura puede manejar para recibir informacion importante sobre diferentes aspectos de la motivacion de sus alumnos hacia la educacion fisica, de esta forma tendria datos que le servirian para planificar su trabajo teniendo en cuenta las corrientes contemporaneas de las clases, para hacer de la signatura, una materia mas productiva en el orden cognoscitivo y dejar atras un poco lo fisico-recreativo como factor fundamental
CHANNELS AND VALLEYS (2022)

More than 200 channels and valleys have been identified on the Magellan images of Venus. These are classified, on the basis of morphology. as simple channels (including sinuous rilles, simple channels with flow margins. and canali), complex channels (with or without flow margins), compound channels, and valley networks (including rectangular, labyrinthic, and pitted or irregular networks). Sinuous rilles closely resemble their lunar counterparts. Canali are exceptional for their remarkably constant width along very extenuated flow paths, exceeding 500 km. One of the compound channels, the outflow complex of Kallistos Vallis. extends over 1200 km and is up to 30 km wide. Venusian channels are globally distributed, but each class has a preferential topographic association. The canali are developed on the volcanic plains. while sinuous rilles occur at higher elevations, associated with volcanic complexes and coronae. Both canali and sinuous rilles have been deformed by post-emplacement tectonism. Highly fluid lavas, erupted at sustained, high discharges seem best to explain many of the channel features, particularly for the canali and the compound channels. Explanation of the canali morphologies may also involve unusual low-viscosity lavas, perhaps of exotic composition.
CONTENT BASED MEDICAL IMAGE RETRIEVAL USING BINARY ASSOCIATION RULES (2013)

In this study, we propose a content-based medical image retrieval framework based on binary association rules to augment the results of medical image diagnosis, for supporting clinical decision making. Specifically, this work is employed on scanned Magnetic Resonance brain Images (MRI) and the proposed Content Based Image Retrieval (CBIR) process is for enhancing relevancy rate of retrieved images. The pertinent features of a query brain image are extracted by applying third order moment invariant functions, which are then examined with the selected feature indexes of large medical image database for appropriate image retrieval. Binary association rules are incorporated here for organizing and marking the significant features of database images, regarding a specific criterion. Trigonometric function distance similarity measurement algorithm is applied to improve the accuracy rate of results. Moreover, the performances of classification and retrieval methods are determined in terms of precision and recall rates. Experimental results reveal the efficacy of the adduced methodology as compared to the related works.
Observation of Hydrogen Permeation into Fresh Bearing Steel Surface by Thermal Desorption Spectroscopy (2011)

This paper describes an experimental study on permeation of hydrogen into bearing steel through fresh surface with thermal desorption spectroscopy. Sliding experiments using a lapping machine with and without lubricant were conducted to generate fresh surfaces. Desorption spectra were taken before and after sliding, and the surfaces were analyzed with X-ray photoelectron spectroscopy. It was found that oxide and/or hydroxide film was formed on the surface, whereby hydrogen was generated and diffused into the bulk steel. When heated, some of hydrogen in the steel reacted with the surface film to be desorbed as water, while some other hydrogen was desorbed in the form of hydrogen molecules. Hydrogen desorption spectra in combination with water desorption spectra thus provides information not only on hydrogen permeated but also on surface oxide/hydroxide film.