gebhart/patrepeval huggingface dataset:
Proton and Carbon Linacs for Hadron Therapy (2014)

Beams of 200 MeV protons and 400 MeV/u fully stripped carbon ions are used for the treatment of solid tumours seated at a maximum depth of 27 cm. More than 100’000 patients have been treated with proton beams and more than 10’000 with carbon ions. Very low proton currents - of the order of 1 nA - are enough to deliver the typical dose of 2 Gy/l in one minute. In the case of carbon ions the currents are of the order of 0.1-0.2 nA. For this reason 3 GHz linacs are well suited in spite of the small apertures and low duty cycle. The main advantage of linacs, pulsing at 200-400 Hz, is that the output energy can be continuously varied pulse-by-pulse and in 2-3 min a moving tumour target can be covered about 10 times by deposing the dose in many thousands of ‘spots’. High frequency hadron therapy linacs have been studied in the last 20 years and are now being built as hearts of proton therapy centres, while carbon ion linacs are still in the designing stage. At present the main challenges are the reduction of the footprint of compact ‘single-room’ proton machines and the power efficiency of dual proton and carbon ions ‘multi-room’ facilities.
La STS de 11 de septiembre de 2019: vencimiento anticipado y seguridad jurídica. ¿Ordenando el caos? Luces y sombras (2019)

espanoln el presente articulo se analizaran los antecedentes de la sentencia del Tribunal Supremo, Sala I, de 11 de septiembre de 2019 sobre los efectos de la nulidad de la clausula de vencimiento anticipado por abusiva, asi como si el Tribunal Supremo ha logrado la seguridad juridica en esta materia, y las sombras y luces en cuanto a la adecuacion de su pronunciamiento con respecto a la Jurisprudencia del Tribunal de Justicia de la Union Europea EnglishThis article analyses the background to the Tribunal Supremo (Supreme Court) ruling, Chamber I, of 11 September 2019 on the effects of the nullity of the early expiration clause as abusive, as well as whether the Supreme Court has achieved legal certainty in this matter and the shadows and lights as to the adequacy of its ruling with respect to the case law of the Court of Justice of the European Union.
Lower Bounds on Crosspoints in Concentrators (1982)

Lower bounds on the required number of crosspoints in concentrators, a class of interconnection networks, are given. The lower bounds are obtained from a straightforward necessary condition on the number of crosspoints in sparse crossbar full capacity concentrators. Because this condition must be satisfied by all full capacity concentrators embedded in more general concentrators, the general necessary condition is established. Several sparse crossbar designs that contain the minimum number of crosspoints are presented. An extension of the results to a more general class of interconnection networks is described.
Quantitative Analysis of Culture Using Millions of Digitized Books (2010)

We constructed a corpus of digitized texts containing about 4% of all books ever printed. Analysis of this corpus enables us to investigate cultural trends quantitatively. We survey the vast terrain of 'culturomics,' focusing on linguistic and cultural phenomena that were reflected in the English language between 1800 and 2000. We show how this approach can provide insights about fields as diverse as lexicography, the evolution of grammar, collective memory, the adoption of technology, the pursuit of fame, censorship, and historical epidemiology. Culturomics extends the boundaries of rigorous quantitative inquiry to a wide array of new phenomena spanning the social sciences and the humanities.
A proposal for a tunable light storage method based on Quasi-Light-Storage and frequency-to-time-conversion (2010)

We propose a quasi-light-storage method which is based on frequency-to-time conversion and capable of being integrated with a delay-bitrate product of 50 bits. The delay can be tuned in fine and coarse range easily.
Clinical Implications of Imipramine Plasma Levels for Depressive Illness (1977)

Sixty depressed nonschizophrenic patients were admitted to a research unit. Following one drug-free week and one week of placebo, patients received 3.5 mg/kg of imipramine hydrochloride for 28 days. Plasma levels of imipramine and its metabolite desipramine hydrochloride (desmethylimipramine) were measured three times weekly and the relationship between plasma steady-state levels and clinical outcome was examined. Steady-state levels ranged from 50 to 1,050 ng/ml. There was a statistically and clinically significant relationship between plasma levels and response. The relationship existed across the entire sample, and was accentuated when the bipolar and unipolar nondelusional populations were examined. Because a strong relationship between sex and outcome was observed, the unipolar nondelusional patients were stratified by sex and a significant relationship still persisted. Only the unipolar delusional patients failed to demonstrate an association between blood level and clinical response.
Structures of two molluscan hemocyanin genes: Significance for gene evolution (2001)

We present here the description of genes coding for molluscan hemocyanins. Two distantly related mollusks, Haliotis tuberculata and Octopus dofleini, were studied. The typical architecture of a molluscan hemocyanin subunit, which is a string of seven or eight globular functional units (FUs, designated a to h, about 50 kDa each), is reflected by the gene organization: a series of eight structurally related coding regions in Haliotis, corresponding to FU-a to FU-h, with seven highly variable linker introns of 174 to 3,198 bp length (all in phase 1). In Octopus seven coding regions (FU-a to FU-g) are found, separated by phase 1 introns varying in length from 100 bp to 910 bp. Both genes exhibit typical signal (export) sequences, and in both cases these are interrupted by an additional intron. Each gene also contains an intron between signal peptide and FU-a and in the 3' untranslated region. Of special relevance for evolutionary considerations are introns interrupting those regions that encode a discrete functional unit. We found that five of the eight FUs in Haliotis each are encoded by a single exon, whereas FU-f, FU-g, and FU-a are encoded by two, three and four exons, respectively. Similarly, in Octopus four of the FUs each correspond to an uninterrupted exon, whereas FU-b, FU-e, and FU-f each contain a single intron. Although the positioning of the introns between FUs is highly conserved in the two mollusks, the introns within FUs show no relationship either in location nor phase. It is proposed that the introns between FUs were generated as the eight-unit polypeptide evolved from a monomeric precursor, and that the internal introns have been added later. A hypothesis for evolution of the ring-like quaternary structure of molluscan hemocyanins is presented.
Pneumonia rebound after stopping steroid in a patient with <scp>COVID</scp>‐19: A case report (2021)

Patients with severe coronavirus disease 2019 (COVID-19) can develop a systemic inflammatory response that can lead to lung injury and multisystem organ dysfunction. The current treatment guideline recommends the use of corticosteroids in patients who require supplemental oxygen or are mechanically ventilated. This study reports a patient with severe COVID-19 pneumonia. Initially, the patient was treated with dexamethasone for 10 days and remdesivir for 5 days. There was clinical improvement following the treatments. However, on day 15, the patient experienced rebound pneumonia and clinical deterioration. His clinical condition improved until dexamethasone was re-administered. This case demonstrates the rebound phenomenon after the steroid was discontinued. The duration and timing of steroids are crucial to reduce the risk of prolonged systemic inflammation and rebound pneumonia.
Person tracking for ambient camera selection in complex sports environments (2008)

As pervasive computing technologies are gradually penetrating sport, we are witnessing a proliferating number of research systems that can track athletes during training and/or in competition. Indeed, athlete tracking is a particularly challenging research tasks, which is also a key enabler for a wide range of applications such as ambient personalized broadcasting. In this paper we survey person tracking systems for sport applications and illustrate their limitations for realistic sports environments. As a real-life example we present the robust and high-performance person tracking system developed at the Athens Information Technology, and explain its inability to deal with occlusions, interlacing, adverse and changing light conditions and mostly the strain of the athletes, which are very common in high activity athletic scenes. We also present techniques for dealing with these challenges, along with an architecture for building ambient camera selection environments for broadcasting purposes. These techniques form the basis for the person tracking and ambient camera selection systems that are developed in the scope of the my-e-Director 2012 EC project, which is working towards a realistic prototype system for the London 2012 Olympics.
Temperature and metal vapor near the cathode in copper breaking arcs according to spectroscopic measurement (2000)

The spatial distribution of the intensities of two spectra are measured using the optical filtering spectroscopic method for breaking arcs in air between copper electrodes interrupting circuits of DC 50 V and 2.5 to 5.0 A, and the temperature and the metal-vapor quantity in the cross section of the arc column near the cathode are calculated from these intensities. Results show the distribution of spectral intensities in the cross section of the arc column is nearly symmetrical from the ignition to the extinction of the breaking arc. The total measured spectral intensities and the peak values of spectral intensities in the cross section of the arc column increase at the beginning and thereafter decrease gradually with the development of the breaking arc. At the fluctuation of the arc voltage wave, which occurs in a copper breaking arc, the total values of the measured spectral intensity and the peak intensity increase rapidly and the metal-vapor quantity also increases by a large amount, but change in temperature is slight.
Association of ATG16L1 gene haplotype with inflammatory bowel disease in Indians (2017)

Inflammatory bowel disease (IBD) is characterized by multigenic inheritance. Defects in autophagy related genes are considered to show genetic heterogeneity between populations. We evaluated the association of several single nucleotide polymorphisms (SNPs) in the autophagy related 16 like 1 (ATG16L1) gene with IBD in Indians. The ATG16L1 gene was genotyped for ten different SNPs using DNA extracted from peripheral blood of 234 patients with Crohn's disease (CD), 249 patients with ulcerative colitis (UC) and 393 healthy controls The SNPs rs2241880, rs4663396, rs3792106, rs10210302, rs3792109, rs2241877, rs6737398, rs11682898, rs4663402 and rs4663421 were genotyped using the Sequenom MassArray platform. PLINK was used for the association analysis and pairwise linkage disequilibrium (LD) values. Haplotype analysis was done using Haploview. All SNPs were in Hardy Weinberg equilibrium in cases and controls. The G allele at rs6737398 exhibited a protective association with both CD and UC. The T allele at rs4663402 and C allele at rs4663421 were positively associated with CD and UC. The T allele at rs2241877 exhibited protective association with UC only. The AA genotype at rs4663402 and the GG genotype at rs4663421 were protectively associated with both CD and UC. Haplotype analysis revealed that all the SNPs in tight LD (D' = 0.76-1.0) and organized in a single haplotype block. Haplotype D was positively associated with IBD (P = 5.8 x 10-6 for CD and 0.002 for UC). SNPs in ATG16L1 were associated with IBD in Indian patients. The relevance to management of individual patients requires further study.
N-methylacetamide as an Electrolyte Solvent for Rechargeable Li-O2 Batteries: Unexpected Stability at the O2 electrode (2013)

We report on the use of N-methylacetamide (NMA) as an electrolyte solvent in a rechargeable Li-O2 battery. Despite a relatively high acidity of the secondary amide N-H group, NMA shows unexpected stability toward superoxide. Quantum chemical calculations are used to rationalize this behavior. A Li-O2 cell using a novel NMA/LiNO3 electrolyte is shown to have good cycling performance with a consistent charging profile, Li2O2 formed during discharge, and O2 detected as the primary gaseous product during charge. Resistance of secondary amides to chemical degradation in the O2 electrode makes them attractive candidates as electrolyte solvents for rechargeable Li-O2 batteries.
Sialorrhea: a review of a vexing, often unrecognized sign of oropharyngeal and esophageal disease. (2005)

Saliva is produced by the major salivary glands (parotid, submandibular, and sublingual), as well as several smaller glands. Salivary flow can be altered by multiple entities. There is much written regarding xerostomia ("dry mouth"), the condition related to inhibited or decreased salivary flow. This condition is widely recognized in certain systemic diseases, particularly Sjögren syndrome, diabetes mellitus, after anticholinergic, antihistamine, and decongestant medications, as well as states of enhanced sympathetic drive, such as anxiety or emotional disturbances and various other psychosocial conditions. On the other hand, sialorrhea or ptyalism, the condition of increased salivary flow, is rarely discussed in the clinical literature. Sialorrhea can occur with various neurologic disorders, infections, the secretory phase of the menstrual cycle, heavy metal poisoning, Wilson disease, Angelman syndrome, as well as a relatively unknown condition called idiopathic paroxysmal sialorrhea. Normal salivation may be altered by drugs (such as clozapine, risperidone, nitrazepam, lithium, and bethanecol) that have a cholinergic effect that induces sialorrhea. This report focuses on sialorrhea as it relates to disorders of the oropharynx and esophagus. The patient typically recognizes a problem with excessive "foamy mucus" but does not understand its origin. Infections and obstruction are the most common oropharyngeal causes. Increased salivary flow occurs as a typically subtle manifestation of gastroesophageal reflux disease. This occurrence is referred to as water brash. Idiopathic achalasia and megaesophagus due to the parasite Trypanosoma cruzi are regularly associated with sialorrhea. Esophageal obstruction (foreign body, cancer, or stricture formation), infection, and nasogastric intubation are the more common conditions associated with the symptomatic sequelae of sialorrhea. Sialorrhea-related respiratory and pulmonary complications are greatest in those with a diminished sensation of salivary flow and hypopharyngeal retention. Extremes of age, the chronically debilitated, or those in chronic care facilities, especially associated with cerebrovascular accidents and esophageal cancer, typically comprise this population. For the patient with an intact awareness of saliva, sialorrhea can present with significant social stigmas. Occult drooling or regular oral evacuation into a tissue or "spit cup" is socially incapacitating. This report provides a review of the physiology, pathogenesis, clinical manifestations, and therapeutic options for sialorrhea. Physicians and other healthcare professionals should recognize the importance of sialorrhea as a possible indicator or complication of a variety of disease states of the oropharynx and esophagus as well as its impact on the patient's physical and social quality of life.
Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. (1995)

Mutation of the p53 tumor suppressor gene is one of the earliest identified genetic lesions during malignant progression of human astrocytomas. To assess the functional significance of these mutations, wild-type (WT) p53 genes were introduced into glioblastoma cell lines having mutant, WT, or null endogenous p53 alleles. Populations of cells with mutant or null endogenous p53 alleles and exogenous WT p53 were spontaneously selected in culture for cells expressing only mutant p53 or no p53, which then displayed a growth and tumorigenic phenotype identical to the parental cells. To determine the phenotypic consequences of WT p53 expression before the occurrence of mutations, we developed a single cell assay to monitor WT p53-dependent transcription activity. Transfer and expression of exogenous WT p53 genes to cells with endogenous mutant or deleted, but not WT, p53 alleles caused growth arrest and morphological changes, including increased cell size and acquisition of multiple nuclei. This supports the hypothesis that genetic lesions of the p53 gene play an important role in the genesis of astrocytomas. Furthermore, the high sensitivity of the episomal single cell reporter strategy developed here has potential clinical applications in the rapid screening of patients for germ-line mutations of the p53 gene or any other gene with known targets for transcriptional transactivation.
Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial (2016)

NCT01226992.
Noun Phrase Construction in Academic Research Articles (2017)

The study explored the syntactic complexity and semantic function of noun phrases in TESOL academic research articles. The corpus was comprised of 60 articles (572874 words) from three TESOL journals including TESOL Quarterly, TESOL Journal, and Journal of Second Language Writing. POS tagging was added to the corpus using TagAnt 1.2.0 (Anthony, 2015). A list of 20 highest-frequency nouns was generated using wordlist tool in AntConc 3.3.4 (Anthony, 2014). Based on the specific contexts of these nouns, the researcher analyzed the syntactic complexity of noun phrases in light of their pre-modifiers and post-modifiers. The semantic function of noun phrases was analyzed based on the excerpts generated by the Concordance tool. The results showed that the complexity of noun phrases was dependent on the complexity of their premodifiers and postmodifiers. A complex postmodifier usually contained more than one element, embedding prepositional phrases, nonfinite clauses, or relative clauses. The use of noun phrases enabled the writer to increase cohesion and coherence within and across the text. The findings were of value to both L2 learners and young scholars in developing their writing performance for the target journals in the field
Use of pseudoracemic nitrendipine to elucidate the metabolic steps responsible for stereoselective disposition of nitrendipine enantiomers. (1992)

1. The pharmacokinetics, protein binding, bioavailability and metabolism of (+)-R- and (-)-S-nitrendipine were studied in six healthy subjects following random oral administration of 20 mg (+)-R-, 20 mg (-)-S- and 20 mg R,S-nitrendipine (pseudoracemic mixture of 10 mg [13C4)-(+)-R- and 10 mg (-)-S-enantiomer). 2. After administration of the enantiomers pronounced differences in AUC (R: 29.9 +/- 20.1; S: 123.8 +/- 63.7 ng ml-1 h; P less than 0.05), bioavailability (R: 10.7 +/- 7.4%; S: 44.6 +/- 23.1%; P less than 0.05) and Cmax (R: 14.4 +/- 7.7; S: 72.5 +/- 40.5 ng ml-1; P less than 0.05) were observed between R- and S-nitrendipine. When racemic nitrendipine was given bioavailability and dose normalized AUC and Cmax values of the S-enantiomer were not different from the values after S-nitrendipine-administration. In contrast, bioavailability (R: 10.7% R,S: 22.1%) and dose normalized AUC (R: 15.0; R,S: 29.5 ng ml-1 h and Cmax (R: 7.2; R,S: 16.8 ng ml-1) of R-nitrendipine were doubled following R,S- as compared with R-nitrendipine administration. t1/2 (R: 9.8; S: 9.1 h) and tmax were not different between the enantiomers nor were the values different after administration of the enantiomers or racemate. The fraction unbound in serum of R-nitrendipine was 0.0098 +/- 0.0032 (s.d.) and that of S-nitrendipine was 0.0083 +/- 0.0015 (s.d.). 3. The AUC values of the major pyridine metabolite M1 were similar after administration of R- and S-nitrendipine (S: 114.7 +/- 48.5; R: 71.7 +/- 29.9 ng ml-1 h).(ABSTRACT TRUNCATED AT 250 WORDS)
Mechanical Behavior of Thin Films (1996)

▪ Abstract The phase-field method has recently emerged as a powerful computational approach to modeling and predicting mesoscale morphological and microstructure evolution in materials. It describes a microstructure using a set of conserved and ...Read More
Remote sensing of voids in large concrete structures: runways, taxiways, bridges, and building walls and roofs (1998)

Maintenance of our world's infrastructure presents many unique challenges. Engineering and maintenance personnel must maintain around the clock service to millions of people each year while maintaining millions of cubic meters of concrete distributed throughout facilities. This infrastructure includes runways, taxiways, roadways, walkways, bridges, building walls and roofs. Presently only a limited number of accurate and economical techniques exist to test this myriad of concrete structures for integrity and safety as well as insure that they meet original design specifications. Remote sensing, non-destructive testing techniques, such as Infrared Thermography, Ground Penetrating Radar, Magnetometer and Pachometer, measure physical properties affected by the various materials and conditions found within, and under, concrete infrastructure. These techniques have established reputations for accurate investigations of concrete anomalies. This paper will review the applications of different non- destructive testing techniques on many concrete infrastructure components.
Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential. (1991)

vav, a novel human oncogene, was originally generated in vitro by replacement of its normal 5' coding sequences with sequences from pSV2neo DNA, cotransfected as a selectable marker (S. Katzav, D. Martin-Zanca, and M. Barbacid, EMBO J. 8:2283-2290, 1989). The vav proto-oncogene is normally expressed in cells of hematopoietic origin. To determine whether the 5' rearrangement of vav or its ectopic expression in NIH 3T3 cells contributes to its transforming potential, we isolated murine and human proto-vav cDNA clones as well as human genomic clones corresponding to the 5' end of the gene. Normal proto-vav was poorly transforming in NIH 3T3 cells, whereas truncation of its 5' end greatly enhanced its transforming activity. The relative failure of full-length proto-vav cDNA clones to transform NIH 3T3 cells indicates that the transforming activity of vav is not simply due to ectopic expression. Analysis of the predicted amino terminus of the vav proto-oncogene shows that it contains a helix-loop-helix domain and a leucine zipper motif similar to that of myc family proteins, though it lacks a basic region that is usually found adjacent to helix-loop-helix domains. Loss of the helix-loop-helix domain of proto-vav, either by truncation or by rearrangement with pSV2neo sequences, activates its oncogenic potential.
Silent Film Killed the Clown: Recovering the Lost Life and Silent Film of Marceline Orbes, the Suicidal Clown of the New York Hippodrome, 1905-1915 (2014)

A reconstruction of the life and cultural significance of Marceline Orbes, the early 20th century performing artist who inspired Chaplin and Keaton but took his own life when his career failed. A trans-media article, this piece includes not only a historic inquiry into the role played by Orbes in establishing the 20th century's comedic canon, it includes a reconstruction of his only (and since lost) silent film from 1915.
BEM: Mining Coregulation Patterns in Transcriptomics via Boolean Matrix Factorization (2020)

Supplementary data are available at Bioinformatics online.