gebhart/patrepeval huggingface dataset:
The Effect of Age on the Association between Body-Mass Index and Mortality (1998)

Excess body weight increases the risk of death from any cause and from cardiovascular disease in adults between 30 and 74 years of age. The relative risk associated with greater body weight is higher among younger subjects.
Maximum leakage power estimation for CMOS circuits (1999)

Low supply voltage requires the device threshold to be reduced in order to maintain performance. As the device threshold voltage is reduced, it results in an exponential increase of leakage current in the subthreshold region. The leakage power is no longer negligible in such low voltage circuits. Estimates of maximum leakage power can be used in the design of the circuit to minimize the leakage power. The leakage power is dependent on the input vector. This input pattern dependence of the leakage power makes the problem of estimating the maximum leakage power a hard problem. In this paper, we present graph based algorithms for estimating the maximum leakage power. These algorithms are pattern-independent and do not require simulation of the circuit. Instead the circuit structure and the logic functionality of the components in the circuit are used to create a constraint graph. The problem of estimating the maximum leakage power is then transformed to an optimization problem on the constraint graph. Efficient algorithms on the graph are used to estimate the maximum leakage power dissipated by a circuit. We also present comparisons with exhaustive/long simulations for MCNC/ISCAS-85 benchmark circuits to verify the accuracy of the method.
A Novel Linear Titanium(IV)-POSS Coordination Polymer (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTA Novel Linear Titanium(IV)-POSS Coordination PolymerMichael T. Hay*†, Bradley Seurer‡, Daniel Holmes§, and Andre Lee‡View Author Information† Penn State Beaver, 100 University Drive, Monaca, Pennsylvania 15061‡ Chemical Engineering and Material Science § Department of Chemistry Michigan State University, East Lansing, Michigan 48824*Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2010, 43, 5, 2108–2110Publication Date (Web):February 9, 2010Publication History Received3 December 2009Revised27 January 2010Published online9 February 2010Published inissue 9 March 2010https://doi.org/10.1021/ma9026756Copyright © 2010 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1340Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (830 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Coordination polymers,Infrared light,Oxygen,Phenyls,Silicon Get e-Alerts
Protection-Free One-Pot Synthesis of 2′-Deoxynucleoside 5′-Triphosphates and DNA Polymerization (2011)

By differentiating the functional groups on nucleosides, we have designed and developed a one-pot synthesis of deoxyribonucleoside 5'-triphosphates without any protection on the nucleosides. A facile synthesis is achieved by generating an in situ phosphitylating reagent that reacts selectively with the 5'-hydroxyl groups of the unprotected nucleosides. The synthesized triphosphates are of high quality and can be effectively incorporated into DNAs by DNA polymerase. This novel approach is straightforward and cost-effective for triphosphate synthesis.
Dual Specificity of Src Homology 2 Domains for Phosphotyrosine Peptide Ligands (1997)

SH2 domains mediate protein-protein interactions and are involved in a wide range of intracellular signaling events. SH2 domains are 100-amino acid stretches of protein that bind to other proteins containing phosphotyrosine residues. A current major research goal is formulation of the structural principles which govern peptide-binding specificity in SH2 domains. Several structures (both X-ray and NMR) of SH2 domains have now been determined. Short peptide fragments on the carboxyl-terminal side of the phosphotyrosine residue carry the sequence specific information for SH2 recognition. The bound peptides are held in an extended conformation. However, for the GRB2 SH2 domain, the peptide adopts a beta-turn as the motif for recognition [Rahuel, J., et al. (1996) Nat. Struct. Biol. 3, 586-589]. Our SAR data and molecular modeling studies suggest that many SH2 domains, such as the SH2 domains of Lck, Src, and p85, can interact with high affinity with short peptide sequences at least in two ways which are sequence-dependent. The peptide forms either an extended chain across the D-strand of SH2 domains with anchors at pY and pY+3 or, as in the case of GRB2 SH2, a beta-turn with anchors at pY and pY+2. Due to a bulky tryptophan in its EF1 loop, GRB2 SH2 cannot bind peptide conformations such as the extended chain and thus has a unique specificity.
Analytical modeling of quantization and volume inversion in thin Si-film DG MOSFETs (2002)

A compact physics-based quantum-effects model for symmetrical double-gate (DG) MOSFETs of arbitrary Si-film thickness is developed and demonstrated. The model, based on the quantum-mechanical variational approach, not only accounts for the thin Si-film thickness dependence but also takes into account the gate-gate charge coupling and the electric field dependence; it can be used for FDSOI MOSFETs as well. The analytical solutions, verified via results obtained from self-consistent numerical solutions of the Poisson and Schrodinger equations, provide good physical insight with regard to the quantization and volume inversion due to carrier confinement, which is governed by the Si-film thickness and/or the transverse electric field. A design criterion for achieving beneficial volume-inversion operation in DG devices is quantitatively defined for the first time. Furthermore, the utility of the model for aiding optimal DG device design, including exploitation of the volume-inversion benefit to carrier mobility, is exemplified.
Spore differentiation in a clinical strain of Trichophyton mentagrophytes. (1984)

Spore differentiation and, in particular, arthrosporogenesis in a clinical strain of T. mentagrophytes was investigated using a variety of methods and by altering environmental conditions. Results are discussed with reference to the in vivo situation. Arthrospores were obtained in the presence of increased CO2 tension but not increased N2 tension. High humidity was necessary for arthrospore formation but maturity (i.e. crops of single spores) was associated with conditions of reduced humidity. Desiccation reduced arthrospore viability. Glucose and peptone based media were suitable for arthrospore formation. Arthrospores were produced at 30 degrees C and 37 degrees C, but 30 degrees C is preferred since chlamydospores were prevalent at 37 degrees C. Conditions for production of arthrospore, microconidial and mycelial suspensions are presented.
Extracting evolution of web communities from a series of web archives (2003)

Recent advances in storage technology make it possible to store a series of large Web archives. It is now an exciting challenge for us to observe evolution of the Web. In this paper, we propose a method for observing evolution of web communities. A web community is a set of web pages created by individuals or associations with a common interest on a topic. So far, various link analysis techniques have been developed to extract web communities. We analyze evolution of web communities by comparing four Japanese web archives crawled from 1999 to 2002. Statistics of these archives and community evolution are examined, and the global behavior of evolution is described. Several metrics are introduced to measure the degree of web community evolution, such as growth rate, novelty, and stability. We developed a system for extracting detailed evolution of communities using these metrics. It allows us to understand when and how communities emerged and evolved. Some evolution examples are shown using our system.
Role of Ureaplasma urealyticum in amnionitis (1986)

Ureaplasma urealyticum is commonly isolated from the amniotic fluid of unselected individuals with intact membranes at the time of cesarean section even prior to onset of labor. The risk of placental infection increases with onset of labor, rupture of membranes and number of vaginal examinations. Qualitative cultures of women with clinical signs of intraamniotic infection and matched controls indicate that U. urealyticum can be found in 50% of amniotic fluid samples of both groups thus suggesting that it may not be a cause of clinical amnionitis. To gain further understanding of the potential role of this organism, we performed amniotic fluid and blood cultures and measured serologic responses by enzyme-linked immunosorbent assay in women with clinical intraamniotic infection and matched controls. U. urealyticum was the single most common bacterial species isolated from maternal blood and amniotic fluid but the isolation rate did not differ between symptomatic and asymptomatic women. Also other known pathogenic bacteria were often isolated from amniotic fluids containing ureaplasmas. However, the marked difference in serologic response between symptomatic and asymptomatic women and the occurrence of ureaplasmemia in some suggest that in certain individuals U. urealyticum may be a cause of clinical amnionitis. Serologic responsiveness, ureaplasmemia and isolation of ureaplasmas in pure culture from amniotic fluid of some asymptomatic women suggest that U. urealyticum may also be a cause of clinically silent amnionitis. Previous studies have shown a significant association between chorioamnionitis documented by histopathology and isolation of U. urealyticum from the placenta or infant but not the maternal cervix.(ABSTRACT TRUNCATED AT 250 WORDS)
Attention Augmented Convolutional Networks (2019)

Convolutional networks have enjoyed much success in many computer vision applications. The convolution operation however has a significant weakness in that it only operates on a local neighbourhood, thus missing global information. Self-attention, on the other hand, has emerged as a recent advance to capture long range interactions, but has mostly been applied to sequence modeling and generative modeling tasks. In this paper, we propose to augment convolutional networks with self-attention by concatenating convolutional feature maps with a set of feature maps produced via a novel relative self-attention mechanism. In particular, we extend previous work on relative self-attention over sequences to images and discuss a memory efficient implementation. Unlike Squeeze-and-Excitation, which performs attention over the channels and ignores spatial information, our self-attention mechanism attends jointly to both features and spatial locations while preserving translation equivariance. We find that Attention Augmentation leads to consistent improvements in image classification on ImageNet and object detection on COCO across many different models and scales, including ResNets and a state-of-the art mobile constrained network, while keeping the number of parameters similar. In particular, our method achieves a 1.3% top-1 accuracy improvement on ImageNet classification over a ResNet50 baseline and outperforms other attention mechanisms for images such as Squeeze-and-Excitation. It also achieves an improvement of 1.4 AP in COCO Object Detection on top of a RetinaNet baseline.
Vasopressin receptor expression and mutation analysis in corticotropin-secreting tumors. (1996)

Vasopressin is an important regulator of hypothalamo-pituitary-adrenal axis activation, primarily acting through the V3 receptor (V3R). Many patients with ACTH-secreting pituitary adenomas, but not normal individuals, respond to desmopressin, a relatively V2-specific vasopressin agonist, with increased ACTH and cortisol levels. We have searched for mutations of the V3R gene in ACTH-secreting pituitary adenomas and one ectopic ACTH-secreting tumor. No abnormalities were found in 12 tumors studied by PCR-single strand conformation polymorphism (PCR-SSCP) analysis. We then verified by RT-PCR whether the response to desmopressin was due to overexpression of the V3R or abnormal expression of the V2R in the pituitary tumor. We found that the V2R gene was expressed in a number of corticotroph tumors and in the ACTH-secreting ectopic tumor, and that the V3R gene appears to be overexpressed in these tumors. We conclude that V3R mutations are unlikely to be present in the ACTH-secreting tumors we examined, but that the V2R gene is expressed in the majority of the samples tested, and the V3R is expressed in all of these tumors. We speculate that the response to the desmopressin test observed in patients with Cushing's disease may be due to abnormal expression of V3R or V2R in ACTH-secreting tumors.
Arbitrary-detuning asynchronous optical sampling with amplified laser systems (2015)

We demonstrate that Arbitrary-Detuning ASynchronous OPtical Sampling (AD-ASOPS) makes possible multiscale pump-probe spectroscopy with time delays spanning from picosecond to millisecond. The implementation on pre-existing femtosecond amplifiers seeded by independent free-running oscillators is shown to be straightforward. The accuracy of the method is determined by comparison with spectral interferometry, providing a distribution with a standard deviation ranging from 0.31 to 1.7 ps depending on experimental conditions and on the method used to compute the AD-ASOPS delays.
Modulation of Capacitance Magnitude by Charging/Discharging in Silicon Nanocrystals Distributed Throughout the Gate Oxide in MOS Structures (2004)

In this work, charge trapping in silicon nanocrystals nc-Si distributed throughout the gate oxide in a metal oxide semiconductor MOS structure has been studied. This situation is different from the conventional one with nc-Si confined in a narrow layer embedded in the gate oxide. In the latter, charge trapping in nc-Si leads to a shift in capacitance-voltage characteristic i.e., a change in the flat-band voltage. In contrast, in the former the charge trapping leads to a dramatic reduction in the MOS capacitance. The original capacitance could be recovered after the release of the trapped charges by a small bias, UV light illumination, or low-temperature thermal annealing.
Review (1998)

The classification of amyotrophic lateral sclerosis (ALS) is reconsidered in the light of developments in the molecular pathogenesis and histopathology of the condition. A current view is encapsulated in the El Escorial World Federation of Neurology criteria for the diagnosis of ALS. While intended for research purposes, use of these criteria for entry into clinical trials may result in the exclusion of some patient groups with related disorders that are likely to share aetiological mechanisms but which are not classified as 'definite ALS' or 'probable ALS'. The relationship between ALS and the more restricted motor disorders of progressive lateral sclerosis and progressive muscular atrophy, together with cerebral degenerations including ALS-dementia and ALS-related frontal lobe dementia, are reviewed. The possibility is raised that they all represent syndromic manifestations of a similar pathogenetic cascade whose clinical phenotype depends upon the anatomical selectivity of involvement in each individual. The new evidence regarding the central role of oxidative stress and abnormal glutamatergic neurotransmission in familial and sporadic ALS seem applicable across these disorders. New evidence regarding the molecular pathology of inclusion bodies in these various syndromes, including ubiquitinated inclusions and hyaline conglomerate inclusions, shows striking similarities between them. Marked differences in the anatomical distribution of lesions determine the predominance and type of motor and cognitive features in each syndrome. This concept of a clinicopathological spectrum is potentially of equal relevance to other late onset neurodegenerative disorders including multisystem atrophies, the Lewy body disorders and various manifestations of Alzheimer's disease. It will gain increasing importance as therapies evolve from the symptomatic to those directed at underlying pathogenetic events.
T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 Peroxidase Activity (2010)

Protein kinases are potential targets for the prevention and control of UV-induced skin cancer. T-cell-originated protein kinase (TOPK) is highly expressed in skin cancer cells, but its specific function is still unknown. We investigated the role of TOPK in UVB-induced apoptosis in RPMI7951 human melanoma cells. Liquid chromatography-tandem mass spectrometry analysis was used to identify proteins that bind with TOPK. Immunofluorescence, Western blot, and flow cytometry were used to assess the effect of UVB on TOPK, peroxiredoxin 1 (Prx1), and apoptosis in RPMI7951 cells. TOPK binds with Prx1 and its phosphorylation of Prx1 at Ser-32 is important for regulation of H(2)O(2)-mediated signal transduction. Analysis of the CD spectra of Prx1 and mutant Prx1 (S32A) proteins showed that the secondary structure of Prx1 was significantly altered by phosphorylation of Prx1 at Ser-32. UVB irradiation induced phosphorylation of TOPK in RPMI7951 human melanoma cells and phosphorylated TOPK co-localized with Prx1 in the nucleus. UVB induced the peroxidase activity of Prx1 in vitro and ex vivo. Following treatment with UVB, H(2)O(2) levels and apoptosis were increased in RPMI7951 cells stably expressing TOPK siRNA or stably mutant Prx1 (S32A). Phosphorylation of Prx1 (Ser-32) by TOPK prevents UVB-induced apoptosis in RPMI7951 melanoma cells through regulation of Prx1 peroxidase activity and blockade of intracellular H(2)O(2) accumulation.
Variable‐angle total internal reflection fluorescence microscopy (VA‐TIRFM): realization and application of a compact illumination device (2003)

Summary A novel compact illumination device in variable‐angle total internal reflection fluorescence microscopy (VA‐TIRFM) is described. This device replaces the standard condensor of an upright microscope. Light from different laser sources is delivered via a monomode fibre and focused onto identical parts of a sample under variable angles of total internal reflection. Thus, fluorophores in close proximity to a cell–substrate interface are excited by an evanescent wave with variable penetration depth, and localized with high (nanometre) axial resolution. In addition to quantitative measurements in solution, fluorescence markers of the cytoplasm and the plasma membrane, i.e. calcein and laurdan, were examined using cultivated endothelial cells. Distances between the glass substrate and the plasma membrane were determined using the mathematical algorithm of a four‐layer model, as well as a Gaussian‐shaped intensity profile of the illumination spot on the samples. Distances between 0 and 30 nm in focal contacts and between 100 and 300 nm in other parts of the cell were thus determined. In addition to measurements of cell–substrate topology, the illumination device appears appropriate for numerous applications in which high axial resolution is required, e.g. experiments on endocytosis or exocytosis, as well as measurements of ion concentrations proximal to the plasma membrane. The compact illumination device is also suitable for combining TIRFM with further innovative techniques, e.g. time‐resolved fluorescence spectroscopy, fluorescence lifetime imaging (FLIM) or fluorescence resonance energy transfer (FRET).
Survey on vehicular attacks - building a vulnerability database (2015)

Modern cars are significantly linked to the outside world because of rising number of connections in the vehicle, connections between the vehicle and the exterior environment , e.g. diagnostics and flash interfaces or the numerous amounts of bus systems for data exchange. All these connections are potential security breaches. Previous papers and this research work show that there are a lot of security vulnerabilities in modern car connections. The aim of this paper is to merge the found vulnerabilities and the available results in literature, categorise them in the same way as in Information Technology (IT) and give an outlook on how most problems can be solved. This paper also aims to introduce an example database for automotive IT vulnerabilities.
Superhigh‐Throughput Needleless Electrospinning Using a Rotary Cone as Spinneret (2010)

An electriferous rotating cone is used as spinneret for the production of nanofibers (see image). It is demonstrated that the production rate by this novel approach is several thousand times higher than that by the single-needle electrospinning technique. This novel technique may attract interest for other applications such as recycling expanded polystyrene, textiles, and filtration meshes. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Akerlof, George Arthur (Born 1940) (2008)

George Akerlof is forever associated with his landmark 1970 paper, ‘The market for “lemons”’, which transformed the way economists approach markets where there is a difference between the transacting agents in the information they possess. This concept of asymmetric information, with its major impact on many fields of economics, was singled out when, in 2001, he was awarded the Nobel Memorial Prize in Economics (along with Michael Spence and Joseph Stiglitz). A more comprehensive assessment of his contribution to economics would be as providing a better behavioural underpinning for macroeconomics as a major figure in the New Keynesian movement.
Substance P Actions on Sensory Neurons (1991)

SP is involved in sensory transmission as a mediator of excitation at target tissues following its release from the terminals of certain primary afferent fibers. In view of the pronounced SP effects on the perikarya of sensory neurons, it seems reasonable to suggest that its actions may extend to autoreceptors and to the enhancement of the excitabilities of sensory neurons that do not synthesize the peptide. This hypothesis would be strengthened by the demonstration of nonsynaptic release of SP within sensory ganglia, which would provide another site for interaction of SP with the various component cells of the sensory system.
Single-mode plane-polarized ytterbium-doped large-core fiber laser with 633-W continuous-wave output power (2005)

We demonstrate a cladding-pumped single-mode plane-polarized ytterbium-doped fiber laser generating 633 W of continuous-wave output power at 1.1 microm with 67% slope efficiency and a polarization extinction ratio better than 16 dB. The laser is end pumped through both fiber ends and shows no evidence of roll-over, even at the highest output power, which is limited only by the available pump power.