gebhart/patrepeval huggingface dataset:
Multi-modal sensor fusion algorithm for ubiquitous infrastructure-free localization in vision-impaired environments (2010)

In this paper, we present a unified approach for a camera tracking system based on an error-state Kalman filter algorithm. The filter uses relative (local) measurements obtained from image based motion estimation through visual odometry, as well as global measurements produced by landmark matching through a pre-built visual landmark database and range measurements obtained from radio frequency (RF) ranging radios. We show our results by using the camera poses output by our system to render views from a 3D graphical model built upon the same coordinate frame as the landmark database which also forms the global coordinate system and compare them to the actual video images. These results help demonstrate both the long term stability and the overall accuracy of our algorithm as intended to provide a solution to the GPS denied ubiquitous camera tracking problem under both vision-aided and vision-impaired conditions.
Topological relationship query processing for complex regions in Oracle Spatial (2012)

Although geographic information systems (GIS) and spatial database communities have extensively studied topological relationships for more than two decades, there is little literature describing how to efficiently implement them in GIS and spatial database systems. This is rather surprising considering that topological relationship queries are supported in many GIS and spatial database systems including IBM Informix Spatial and Geodetic DataBlades, ESRI SDE, Microsoft SQL server 2008, Oracle Spatial and PostGIS. In order to bridge this gap, we report our experience with implementing several optimization techniques in Oracle Spatial to speed up topological relationship query processing for query windows represented by complex regions (such as polygons or multi-polygons). Our experiments, utilizing real-world data sets, demonstrate that topological relationship query performance can be significantly improved using the proposed techniques.
Piezoelectric micromachined ultrasonic transducers with increased coupling coefficient via series transduction (2015)

This work demonstrates a new electrode configuration for piezoelectric micromachined ultrasonic transducers (PMUTs) with increased electromechanical coupling coefficient (k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). The electrodes, a center electrode surrounded by a ring electrode, are identical to those used in differential PMUTs. Unlike a differential PMUT, where the two top electrodes (TEs) are referenced to a common ground electrode, here only the two TEs are used, effectively putting the two piezoelectric transducers in series. The benefit of series readout is that the transducer's electrical capacitance is halved, doubling the receive sensitivity and electromechanical coupling coefficient k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Using multidimensional databases for problem determination and planning of a networked application (2002)

Systems management accounts for 60% to 80% of the cost of LAN-connected personal computers. This paper describes a decision support application to reduce systems management costs in the area of problem determination and capacity planning for the Legato Backup System as it is used at Columbia University. Central to the system management tasks addressed is the use of data navigation, especially drill-down, roll-up, and pivot. These operations are provided by multidimensional databases (MDDB). As such, our application includes an MDDB layer. We discuss the application's architecture, the design of the MDDB schema, and outline the operation of the MDDB engine.
An integrated approach to battery health monitoring using bayesian regression and state estimation (2007)

The application of the Bayesian theory of managing uncertainty and complexity to regression and classification in the form of relevance vector machine (RVM), and to state estimation via particle filters (PF), proves to be a powerful tool to integrate the diagnosis and prognosis of battery health. Accurate estimates of the state-of-charge (SOC), the state-of-health (SOH) and state-of-life (SOL) for batteries provide a significant value addition to the management of any operation involving electrical systems. This is especially true for aerospace systems, where unanticipated battery performance may lead to catastrophic failures. Batteries, composed of multiple electrochemical cells, are complex systems whose internal state variables are either inaccessible to sensors or hard to measure under operational conditions. In addition, battery performance is strongly influenced by ambient environmental and load conditions. Consequently, inference and estimation techniques need to be applied on indirect measurements, anticipated operational conditions and historical data, for which a Bayesian statistical approach is suitable. Accurate models of electro-chemical processes in the form of equivalent electric circuit parameters need to be combined with statistical models of state transitions, aging processes and measurement fidelity, need to be combined in a formal framework to make the approach viable. The RVM, which is a Bayesian treatment of the support vector machine (SVM), is used for diagnosis as well as for model development. The PF framework uses this model and statistical estimates of the noise in the system and anticipated operational conditions to provide estimates of SOC, SOH and SOL. Validation of this approach on experimental data from Li-ion batteries is presented.
Bcl-B expression in human epithelial and non-epithelial malignancies. (2008)

2180 Purpose:Apoptosis plays an important role in neoplastic processes. Bcl-B is an anti-apoptotic Bcl-2 family member, which is known to change its phenotype upon binding to Nur77/TR3. The expression pattern of this protein in human malignancies has not been reported.  Experimental Design: We investigated Bcl-B expression in normal human tissues and several types of human epithelial and non-epithelial malignancy by immunohistochemistry and immunoblotting, correlating results with tumor stage, histologic grade, and patient survival.  Results: Bcl-B protein was strongly expressed in all normal plasma cells but found in only 18% of multiple myelomas (n = 133). Bcl-B immunostaining was also present in normal germinal center centroblasts and centrocytes, but follicular lymphomas (n =57) did not contain Bcl-B, while 52% of diffuse large B-cell lymphomas (DLBCLs) (n =48) were immunopositive. In breast (n=119), prostate (n=66), gastric (n=180), and colorectal (n=106) adenocarcinomas, as well as in non-small cell lung cancers (NSCLCs) (n=82), tumor-specific over-expression of Bcl-B was observed. Bcl-B expression was associated with parameters of poor prognosis, such as high tumor grade in breast cancer (p=0.009), microsatellite stability (p=0.0002) and left-sided anatomic location (p=0.02) of colorectal cancers, as well as with greater incidence of death from prostate cancer (p=0.005), and shorter survival and increased relative risk of death from small cell lung cancer (SCLC) (p=0.009). Conversely, although over-expressed in many gastric cancers, Bcl-B tended to correlate with better outcome (p=0.01) and more differentiated tumor histology (p
Compact waveguide orthomode transducer without crossings (2009)

In this paper we propose a new concept of waveguide orthomode transducer that leads to a design without RF-path crossings. The proposed compact design requires only two layers with standard waveguide cross section for the full power combination network. The design is based on a non-conventional use of the turnstile junction combined with two magic tees to separate two orthogonal polarizations. A preliminary design is presented in Ku-band to demonstrate the concept. Good performances are achieved over a large bandwidth.
Ascending-dose study of noribogaine in healthy volunteers: Pharmacokinetics, pharmacodynamics, safety, and tolerability (2014)

Noribogaine is the active metabolite of the naturally occurring psychoactive substance ibogaine, and may help suppress withdrawal symptoms in opioid-dependent subjects. The objectives of this Phase I study were to assess the safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of noribogaine. In this ascending single-dose, placebo-controlled, randomized, double-blind, parallel-group study in 36 healthy drug-free male volunteers, 4 cohorts (n = 9) received oral doses of 3, 10, 30, or 60 mg or matching placebo, with intensive safety and pharmacokinetic assessments out to 216 hours, along with pharmacodynamic assessments sensitive to the effects of mu-opioid agonists. Noribogaine was rapidly absorbed, with peak concentrations occurring 2-3 hours after oral dosing, and showed dose-linear increases of area under the concentration-time curve (AUC) and Cmax between 3 and 60 mg. The drug was slowly eliminated, with mean half-life estimates of 28-49 hours across dose groups. Apparent volume of distribution was high (mean 1417-3086 L across dose groups). No safety or tolerability issues were identified in any cohort. No mu-opioid agonist pharmacodynamic effects were noted in pupillometry or cold-pressor testing. Single oral doses of noribogaine 3-60 mg were safe and well tolerated in healthy volunteers.
Habituation of steady-state visual evoked potentials in response to high-frequency polychromatic foveal visual stimulation (2013)

In an attempt to develop safe and robust methods for monitoring migraineurs' brain states, we explores the feasibility of using white, red, green and blue LED lights flickering around their critical flicker fusion (CFF) frequencies as foveal visual stimuli for inducing steady-state visual evoked potentials (SSVEP) and causing discernible habituation trends. After comparing the habituation indices, the multi-scale entropies and the time dependent intrinsic correlations of their SSVEP signals, we reached a tentative conclusion that sharp red and white light pulses flickering barely above their CFF frequencies can replace commonly used 13Hz stimuli to effectively cause SSVEP habituation among normal subjects. Empirical results showed that consecutive short bursts of light can produce more consistent responses than a single prolonged stimulation. Since these high frequency stimuli do not run the risk of triggering migraine or seizure attacks, further tests of these stimuli on migraine patients are warranted in order to verify their effectiveness.
Stereocontrolled Total Synthesis of (+)-Vinblastine (2002)

A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.
MN and IIIB Recombinant Glycoprotein 120 Vaccine-Induced Binding Antibodies to Native Envelope Glycoprotein of Human Immunodeficiency Virus Type 1 Primary Isolates (1999)

The ability of antibody induced by MN and IIIB recombinant gp120 (rgp120) human immunodeficiency virus type 1 (HIV-1) vaccines to bind to oligomeric native HIV-1 envelope glycoproteins of primary isolates of HIV-1 was measured by flow cytometric indirect immunofluorescence assay (FIFA) in 25 uninfected, healthy adults. After three immunizations, MN rgp120 HIV-1 vaccine given alone and coadministered with IIIB rgp120 HIV-1 vaccine elicited antibody that bound to cells infected with each of a panel of six subtype B strains of HIV-1. Lower levels of vaccine-induced binding antibody were detected against envelope subtype A, D, and (EA) strains of HIV-1 than against subtype B strains. Priming immunization with IIIB rgp120 HIV-1 vaccine alone induced low levels of antibody capable of binding to envelope glycoprotein of primary isolate strains of HIV-1, and booster immunizations with MN rgp120 HIV-1 vaccine resulted in much higher antibody levels. We conclude that MN rgp120 HIV-1 vaccine was an effective inducer of antibody to native envelope glycoproteins of antigenically diverse primary isolates of HIV-1.
Prostate cancer detection and gleason grading of histological images using shearlet transform (2013)

In this paper we propose a method for feature representation and classification of prostate tissue images using the shearlet transform. The objective is to automatically process biopsy tissue images and assist pathologists in analysing carcinoma cells. Furthermore, we will automatically grade the cancer using the Gleason grading system. The main contribution of this paper is the use of a holistic based method instead of going through the tedious task of image segmentation, and the use of the shearlet method instead of traditional signal processing methods. Compared with wavelet filters such as the Gabor filter, shearlet has inherent directional sensitivity which makes it suitable for characterizing small contours of carcinoma cells. By applying a multi-scale decomposition, the shearlet transform captures visual information provided by edges detected at different orientations and multiple scales. Each image is represented using histogram of shearlet coefficients and then used for classification of benign and malignant tissues and also Gleason grading of cancer using support vector machines. Our results show that we can achieve a classification rate of 100% for distinguishing benign from cancer cells and an accuracy of 89% for Gleason grading while we maintain low complexity comparing to other methods.
Fabrication of a Flexible Graphene Pressure Sensor (2015)

The electromechanical properties of single-layer graphene have inspired specific application to force sensors, sinceit is capable of sensing within the range of human pressure perception. In this study, we present a pressure sensor for vertical force that is flexible and transparent by introducing a single graphene layer on a polyethylene naphthalate substrate. This substrate is commonly used as a force absorber in sensors. By employing it with a pressure amplifying structure, the performance of the sensor shows a reliable resistance change of 0.15% per 1 kPa of applied vertical pressure. Detection for the motion of the finger joint and touching are demonstrated with the sensor equipped on the human body.
Clinical significance of low levels of minimal residual disease at the end of remission induction therapy in childhood acute lymphoblastic leukemia (2010)

Minimal residual disease (MRD) at the end of remission-induction therapy predicts relapse in acute lymphoblastic leukemia (ALL). We examined the clinical significance of levels below the usual threshold value for MRD positivity (0.01%) in 455 children with B-lineage ALL, using polymerase chain reaction amplification of antigen-receptor genes capable of detecting at least 1 leukemic cell per 100 000 normal mononucleated cells (0.001%). Of the 455 clinical samples studied on day 46 of therapy, 139 (30.5%) had MRD 0.001% or more with 63 of these (45.3%) showing levels of 0.001% to less than 0.01%, whereas 316 (69.5%) had levels that were either less than 0.001% or undetectable. MRD measurements of 0.001% to less than 0.01% were not significantly related to presenting characteristics but were associated with a poorer leukemia cell clearance on day 19 of remission induction therapy. Patients with this low level of MRD had a 12.7% (+/- 5.1%; SE) cumulative risk of relapse at 5 years, compared with 5.0% (+/- 1.5%) for those with lower or undetectable MRD (P < .047). Thus, low levels of MRD (0.001%-< 0.01%) at the end of remission induction therapy have prognostic significance in childhood ALL, suggesting that patients with this finding should be monitored closely for adverse events.
The global Alzheimer's Association round robin study on plasma amyloid β methods (2021)

The poor correlations for Aβ42 in plasma might have several potential explanations, such as the high levels of plasma proteins (compared to CSF), sensitivity to pre-analytical sample handling and specificity, and cross-reactivity of different antibodies. Different methods might also measure different pools of plasma Aβ42. We, however, hypothesize that greater correlations might be seen in future studies because many of the methods have been refined during completion of this study.
Compressed Mints and Chewing Gum Containing Magnolia Bark Extract Are Effective against Bacteria Responsible for Oral Malodor (2007)

Flavors and natural botanic extracts are often used in chewing gum and compressed mints for breath freshening and relief of oral malodor. The oral malodor is a result of bacterial putrification of proteinaceous materials from food or saliva. In this study, magnolia bark extract (MBE) and its two main components, magnolol and honokiol, were evaluated by the minimum inhibition concentration (MIC) test. The inhibitory effect of MBE mint was further evaluated by a kill-time assay study. In addition, an in vivo study was performed on nine healthy volunteers postlunch. Saliva samples were taken before and after subjects consumed mints and gum, with and without MBE. Listerine mouthwash was included as a positive control. The testing results indicated that MBE and its two main constituents demonstrated a strong germ-kill effect against bacteria responsible for halitosis and also Streptococcus mutans, bacteria involved in dental caries formation. The MIC of magnolol, honokiol, and MBE on Porphyromonas gingivalis, Fusobacterium nucleatum, and S. mutans ranged from 8 to 31 microg/mL. Kill-time assay results indicated that mints containing 0.2% MBE reduced more than 99.9% of three oral bacteria within 5 min of treatment. The in vivo study demonstrated that MBE containing mints reduced total salivary bacteria by 61.6% at 30 min and 33.8% at 60 min postconsumption. In comparison, the flavorless mint reduced total salivary bacteria by 3.6% at 30 min and increased total bacteria by 47.9% at 60 min. The MBE containing chewing gum reduced total salivary bacteria by 43.0% at 40 min, while placebo gum reduced total salivary bacteria by 18.0%. In conclusion, MBE demonstrated a significant antibacterial activity against organisms responsible for oral malodor and can be incorporated in compressed mints and chewing gum for improved breath-freshening benefits.
Automatic, efficient, temporally-coherent video enhancement for large scale applications (2009)

A fast and robust method for video contrast enhancement is presented. The method uses the histogram of each frame, along with upper and lower bounds computed per shot in order to enhance the current frame. This ensures that the artifacts introduced during the enhancement is reduced to a minimum. Traditional methods that do not compute per-shot estimates tend to over-enhance parts of the video such as fades and transitions. Our method does not suffer from this problem, which is essential for a fully automatic algorithm. We present the parameters for our methods which yielded the best human feedback, which showed that out of 208 videos, 203 were enhanced, while the remaining 5 were of too poor quality to be enhanced. Additionally, we present a visual comparison of our work with the recently-proposed Weighted Thresholded Histogram Equalization (WTHE) algorithm.
Functional Coverage Driven Test Generation for Validation of Pipelined Processors (2005)

Functional verification of microprocessors is one of the most complex and expensive tasks in the current system-on-chip design process. A significant bottleneck in the validation of such systems is the lack of a suitable functional coverage metric. The paper presents a functional coverage based test generation technique for pipelined architectures. The proposed methodology makes three important contributions. First, a general graph-theoretic model is developed that can capture the structure and behavior (instruction-set) of a wide variety of pipelined processors. Second, we propose a functional fault model that is used to define the functional coverage for pipelined architectures. Finally, test generation procedures are presented that accept the graph model of the architecture as input and generate test programs to detect all the faults in the functional fault model. Our experimental results on two pipelined processor models demonstrate that the number of test programs generated by our approach to obtain a fault coverage is an order of magnitude less than those generated by traditional random or constrained-random test generation techniques.
Microwatt-power InGaAs photogenerator for lightwave networks (1997)

A 3×3 array of series-connected InGaAs photodetectors was used as a photogenerator to optically power a remotely-located microwatt-power optical shutter intended for use in a lightwave network. The conversion efficiency of the photogenerator was 7×10/sup -3/ A/W when the device was illuminated at 1550 nm from the output of a single-mode fiber; the open-circuit voltage was 2 V with 300 μW of incident power.
Ultra-Low Viscosity and High Magnetic Susceptibility Magnetic Ionic Liquids Featuring Functionalized Diglycolic Acid Ester Rare-Earth and Transition Metal Chelates (2023)

Magnetic ionic liquids (MILs) comprise a subcategory of ionic liquids (ILs) and contain a paramagnetic metal center allowing them to be readily manipulated by an external magnetic field. While MILs are popularly employed as solvents in catalysis, separations, and organic synthesis, most low viscosity combinations possess a hydrophilic character that limits their use in aqueous matrices. To date, no study has reported the synthesis and characterization of hydrophobic MILs with viscosities similar to those of hydrophilic MILs and organic solvents while simultaneously exhibiting enhanced magnetic and thermal properties. In this study, diglycolic acid esters are employed as ligands to chelate with paramagnetic metals to produce cations that are paired with metal chelates composed of hexafluoroacetylacetonate ligands to form MILs incorporating multiple metal centers in the cation and anion. Viscosity values below 31.6 cP were obtained for these solvents, the lowest ever reported for hydrophobic MILs. Solubilities in nonpolar solvents such as benzene were observed to be as high as 50% (w/v) MIL-to-solvent ratio while being insoluble in water at concentrations as low as 0.01% (w/v). Effective paramagnetic moment values for these solvents ranged from 5.33 to 15.56 Bohr magnetons (μ<sub>B</sub>), with mixed metal MILs containing multiple lanthanides in the anion generally offering higher magnetic susceptibilities. MILs composed of ligands containing octyl substituents were found to possess thermal stabilities up to 190 °C. The synthetic strategies explored in this study exploit the highly tunable nature of the employed cation and anion pairs to design versatile ultra-low viscosity magnetoactive solvents that possess tremendous potential and applicability in liquid-liquid separation systems, catalysis, and microfluidics where the mechanical movement of the solvent can be easily facilitated using electromagnets.