gebhart/patrepeval huggingface dataset:
An Analog-Assisted Tri-Loop Digital Low-Dropout Regulator (2017)

This paper presents an analog-assisted (AA) output-capacitor-free digital low-dropout (D-LDO) regulator with tri-loop control. For responding to instant load transients, the proposed high-pass AA loop momentarily adjusts the unit current of the power switch array, and significantly reduces the voltage spikes. In the proposed D-LDO, the overall 512 output current steps are divided into three sub-sections controlled by coarse/fine loops with carry-in/out operations. Therefore, the required shift register (SR) length is reduced, and a 9-bit output current resolution is realized by using only 28-SR bits. Besides, the coarse-tuning loop helps to reduce the recovery time, while the fine-tuning loop improves the output accuracy. To eliminate the limit cycle oscillation and reduce the quiescent current, a freeze mode is added after the fine-tuning operation. To reduce the output glitches and the recovery time, a nonlinear coarse word control is designed for the carry-in/out operations. The D-LDO is fabricated in a 65-nm general purpose CMOS process. A maximum voltage undershoot/overshoot of 105 mV is measured with a 10-mA/1-ns load step and a total capacitor of only 100 pF. Thus, the resulting figure-of-merit is 0.23 ps.
Frequency-modulation-polarization spectroscopy (1983)

We have combined frequency-modulation and polarization spectroscopy to detect anisotropic spectral features with high sensitivity. The many line shapes possible with this technique and the potential for laser noise suppression were demonstrated by using saturation holes in iodine vapor.
Modeling of integrated EMI filter with flexible multi-layer (FML) foils (2009)

A model of Distributed Electromagnetic Component (DEMC) for integrated EMI filter based on FML foil is proposed in this paper. The model is used for estimating the insertion loss of integrated EMI filter with FML foils. In this model, distributed parameters such as parasitic capacitance, magnetic coupling between conductors, core loss, copper loss, dielectric loss of the magnetic core are all included. Prototype was built. The model is verified by the experiment.
Multimedia Data Hiding and Authentication via Halftoning and Coordinate Projection (2002)

We present image data hiding and authentication schemes based on halftoning and coordinate projection. The proposed data hiding scheme can embed images of the same size and similar bit depth into the cover image and robustness against compression is demonstrated. The image authentication scheme is based on the data hiding scheme and can detect, localize, and repair the tampered area of the image. Furthermore, the self-repairing feature of the authentication scheme has a hologram-like quality; any portion of the image can be used to reconstruct the entire image, with a greater quality of reconstruction as the portion size increases.
Deposited silicon high-speed integrated electro-optic modulator (2009)

We demonstrate a micrometer-scale electro-optic modulator operating at 2.5 Gbps and 10 dB extinction ratio that is fabricated entirely from deposited silicon. The polycrystalline silicon material exhibits properties that simultaneously enable high quality factor optical resonators and sub-nanosecond electrical carrier injection. We use an embedded p(+)n(-)n(+) diode to achieve optical modulation using the free carrier plasma dispersion effect. Active optical devices in a deposited microelectronic material can break the dependence on the traditional single layer silicon-on-insulator platform and help lead to monolithic large-scale integration of photonic networks on a microprocessor chip.
<i>N</i>-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1<i>H</i>)-yl)carboxamides:  Identification of Novel Orthopoxvirus Egress Inhibitors (2007)

A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using structure--activity relationship information inferred from early hits, several compounds were synthesized, and compound 14 was identified as a potent, orally bioavailable first-in-class inhibitor of orthopoxvirus egress from infected cells. Compound 14 has shown comparable efficaciousness in three murine orthopoxvirus models and has entered Phase I clinical trials.
Transducer drive and control (1982)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Bayard G. Gardineer, George W. Leber; Transducer drive and control. J. Acoust. Soc. Am. 1 June 1982; 71 (6): 1627. https://doi.org/10.1121/1.387877 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
MR angiography using velocity‐selective preparation pulses and segmented gradient‐echo acquisition (1993)

We describe a cardiac-gated MR angiographic imaging method that employs velocity-selective preparation (VSP) pulses in conjunction with segmented gradient-echo acquisition and subtraction to produce images that, ideally, contain no signal from stationary tissues and display vessels with a signal intensity that is dependent on the velocity of the blood in the vessels. The novel features of this method are a) it acquires several phase-encoding values/application of a single VSP pulse, b) it uses subtraction to eliminate signal that is not sufficiently suppressed by the VSP pulses, and c) it uses VSP pulses that are synchronized with the cardiac cycle so it can be used to produce ghost-free images of pulsatile blood. An advantage of this sequence is that it detects a signal that, after preparation, is relatively unaffected by changes in blood velocity. This leads to a large signal-to-noise ratio for all the phase-encoding values, a reduction of ghosting artifacts, and the ability to visualize blood that is in motion for only a short time during the cardiac cycle. Because the signal is prepared during peak flow, venous signal can be suppressed by making the sequence sensitive to high velocities. An additional advantage of this sequence is that it permits sampling with a short TE because the velocity-encoding gradient can be applied in a preparatory interval. Signal loss that results from dephasing during the longer TE preparation interval can be reduced or eliminated by allowing the dephased spins to flow out of the region of complex flow, and perhaps out of the field-of-view, by introducing a delay between the finish of the VSP pulse and the beginning of data acquisition.
Signature of near dipole-dipole interaction in a dense medium of two-level systems (1992)

We performed a numerical investigation of the dynamics of the optical Bloch equations, extended for near dipole-dipole (NDD) interactions in dense collections of two-level systems. As a function of peak field strength, the inversion that remains in the medium following excitation by an ultrashort optical pulse has step-like transitions between the ground state and the excited state. The medium is left fully inverted if the peak Rabi frequency (peak field strength written in units of frequency) is equal to the NDD interaction strength. Remarkably, this result is independent of pulse area. About this point is a region of peak field strength for which the dense medium is left fully, or nearly fully, inverted. On the weak side of this region, the dense medium is left in the ground state. On the strong side of this region, the medium alternates between absorbing (ground state) and amplifying (inverted) as a function of peak field strength. This response can be used to measure the strength of the NDD interaction, for coherent optical pumping, and also constitutes a new and unique intrinsic optical switch, which, unlike optical bistability, does not have hysteresis and is independent of dissipation from incoherent effects.
Optimal Implementation of Miniature Piezoelectric Panel Speakers Using the Taguchi Method and Genetic Algorithm (2004)

A thin and miniature piezoelectric panel speaker has been developed in this paper. The system is modeled using the energy method in conjunction with the finite element method. The electrical system, mechanical system and acoustic loading are considered in combined fashion. The genetic algorithm (GA) and the Taguchi method are employed to achieve optimal designs with low fundamental frequency and high acoustic output. The designs resulting from the optimization are then implemented and evaluated by experiments. These experiments were carried out on the basis of quantitative and subjective performance measures. The experimental results indicate that the piezoelectric panel speakers are capable of producing comparable acoustic output with significantly less electrical power than the conventional voice-coil panel speakers.
Room-temperature in situ nuclear spin hyperpolarization from optically pumped nitrogen vacancy centres in diamond (2015)

Low detection sensitivity stemming from the weak polarization of nuclear spins is a primary limitation of magnetic resonance spectroscopy and imaging. Methods have been developed to enhance nuclear spin polarization but they typically require high magnetic fields, cryogenic temperatures or sample transfer between magnets. Here we report bulk, room-temperature hyperpolarization of (13)C nuclear spins observed via high-field magnetic resonance. The technique harnesses the high optically induced spin polarization of diamond nitrogen vacancy centres at room temperature in combination with dynamic nuclear polarization. We observe bulk nuclear spin polarization of 6%, an enhancement of ∼170,000 over thermal equilibrium. The signal of the hyperpolarized spins was detected in situ with a standard nuclear magnetic resonance probe without the need for sample shuttling or precise crystal orientation. Hyperpolarization via optical pumping/dynamic nuclear polarization should function at arbitrary magnetic fields enabling orders of magnitude sensitivity enhancement for nuclear magnetic resonance of solids and liquids under ambient conditions.
Distributed Adaptive Beamforming and Nullforming for Covert Wireless Communications (2019)

In this paper, we focus on the problem of distributed coherent beamforming in wireless networks where multiple distributed transmitters adjust the phases of their signals to form a directional and targeted communication link to a client receiver. The quality-of-service (QoS) and security are key aspects of robust and covert wireless networks. Although the security can be enhanced by exploiting information about the locations of adversaries, such information may not be available in practical networks since the adversaries are often passive. Therefore, we propose transmission strategies which divide transmitters into two groups where one group forms a beam towards the client and the other group broadcasts interference in order to obfuscate adversaries. As the interference may degrade the QoS of the client, the latter group steers a null to the client to alleviate the interference at the client. The proposed scheme can be performed in a fully distributed manner with only two bits of feedback information from the client and without any knowledge about the locations of potential adversaries.
Joining of Advanced Structural Materials by Plastic Deformation (2008)

Superplastic deformation has been employed to join nickel aluminide (Ni3Al) at temperatures of 1000–1200°C and strain rates ranging from 1 × 10−5/s to 5 × 10−3/s. Optimum joining was achieved at 1100°C for strain rates ranging from 1 × 10−4/s to 9 × 10−4/s. Corresponding flow stresses were 47–123 MPa with permanent strains ≈10%. the room-temperature stress-strain of the joined flexure bars made at 1100°C was similar to that of monolithic samples. the role of surface oxidation conducted at 1100–1200°C on the joint quality was also investigated.
Test generator with preselected toggling for low power built-in self-test (2012)

This paper presents a new pseudorandom test pattern generator with preselected toggling (PRESTO) activity. It is comprised of a linear finite state machine (a linear feedback shift register or a ring generator) driving an appropriate phase shifter and armed with a number of features that allows this device to produce binary sequences with low toggling (switching) rates while preserving test coverage achievable by the best-to-date conventional BIST-based PRPGs with negligible impact on test application time.
Studies in Chimpanzees of Live, Attenuated Hepatitis A Vaccine Candidates (1983)

Human hepatitis A virus was attenuated in virulence for chimpanzees by passage in FRhK6 and human diploid lung fibroblast cell cultures. A number of variants were developed by passage in cell cultures which showed different levels of virulence/attenuation for chimpanzees. These results were compared to those obtained with marmosets and reported previously. In general, most variants behaved similarly in the two animal types. Two chimpanzees which gave vaccine-like responses following inoculation with HAV cell culture variants were challenged with virulent HAV. Both animals were immune to HAV infection. These findings provide further evidence for the feasibility of developing live, attenuated vaccines against human hepatitis A.
High-throughput Identification of FLT3 Wild-type and Mutant Kinase Substrate Preferences and Application to Design of Sensitive In Vitro Kinase Assay Substrates (2018)

Acute myeloid leukemia (AML) is an aggressive disease that is characterized by abnormal increase of immature myeloblasts in blood and bone marrow. The FLT3 receptor tyrosine kinase plays an integral role in hematopoiesis, and one third of AML diagnoses exhibit gain-of-function mutations in FLT3, with the juxtamembrane domain internal tandem duplication (ITD) and the kinase domain D835Y variants observed most frequently. Few FLT3 substrates or phosphorylation sites are known, which limits insight into FLT3's substrate preferences and makes assay design particularly challenging. We applied <i>in vitro</i> phosphorylation of a cell lysate digest (adaptation of the Kinase Assay Linked with Phosphoproteomics (KALIP) technique and similar methods) for high-throughput identification of substrates for three FLT3 variants (wild-type, ITD mutant, and D835Y mutant). Incorporation of identified substrate sequences as input into the KINATEST-ID substrate preference analysis and assay development pipeline facilitated the design of several peptide substrates that are phosphorylated efficiently by all three FLT3 kinase variants. These substrates could be used in assays to identify new FLT3 inhibitors that overcome resistant mutations to improve FLT3-positive AML treatment.
Development of a Two-Axis Robotic Platform for the Characterization of Two-Dimensional Ankle Mechanics (2019)

Accurate characterization of ankle mechanics in lower extremity function is essential to advance the design and control of robots physically interacting with the human lower extremities, such as lower limb exoskeletons, active orthoses, and prostheses. This paper presents a two-axis robotic platform developed for the characterization of important neuromechanical properties of the human ankle, namely mechanical impedance and energetic passivity. This robotic platform is capable of simulating a wide range of mechanical (haptic) environments as well as applying precisely controlled perturbations to the ankle in 2 degrees-of-freedom (DOF) spanning both the sagittal and frontal planes. These features provide us with a unique way to characterize two-dimensional ankle mechanics while humans perform various lower extremity tasks in realistic physical environments. A series of validation experiments demonstrated that the platform can provide rapid perturbations up to an angular velocity of 100°/s with an error less than 0.1° even under excessive loading and simulate a wide range of haptic environments, from compliant to highly stiff environments, with an error less than 2.1% of the commanded values. A pilot human study demonstrated that the robotic platform could accurately quantify intrinsic ankle impedance in 2 DOFs with reliability higher than 97.5%. This study also confirmed that the platform could be utilized to quantify energetic passivity of the ankle in 2 DOFs. Implications for the design and control of lower extremity robots are discussed.
Learning the Latent Semantic Space for Ranking in Text Retrieval (2008)

Subspace learning techniques for text analysis, such as latent semantic indexing (LSI), have been widely studied in the past decade. However, to our best knowledge, no previous study has leveraged the rank information for subspace learning in ranking tasks. In this paper, we propose a novel algorithm, called learning latent semantics for ranking (LLSR), to seek the optimal latent semantic space tailored to the ranking tasks. We first present a dual explanation for the classical latent semantic indexing (LSI) algorithm, namely learning the so-called latent semantic space (LSS) to encode the data information. Then, to handle the increasing amount of training data for the practical ranking tasks, we propose a novel objective function to derive the optimal LSS for ranking. Experimental results on two SMART sub-collections and a TREC dataset show that LLSR effectively improves the ranking performance compared with the classical LSI algorithm and ranking without subspace learning.
Digital Holographic Adaptive Optics Techniques with Coherent or Incoherent Sources (2012)

We have recently proposed two distinct digital holographic adaptive optics techniques, one involving holography of coherent sources and the other incoherent digital holography. Progress on development of the two systems is described and compared.
Molecular nanoelectronics (2000)

Both molecular switching and nanoscale wires have been recently demonstrated. We discuss their possible applications in circuits with emphasis on cross-point memories and programmable logic arrays.
CRM1 knockdown by ratjadone C, leptomycin B, and siRNA to CRM1, enhance sensitivity of human multiple myeloma cells to topoisomerase II inhibitors. (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

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In previous studies we have shown that topoisomerase II alpha (topo IIa) is exported from the nucleus to the cytoplasm by a CRM1-associated mechanism at high cell densities, similar to those found in multiple myeloma patient (MM) bone marrow (Turner et al, J. Cell Science 117:3061-3071, 2004). Under such conditions, the cells are highly resistant to topo II poisons. We hypothesize that drug resistance depends on topo IIa trafficking to the cytoplasm where it would not be in contact with the DNA, and therefore unable to produce DNA cleavable complexes and subsequent cell death. Based on these findings, we have blocked topo IIa export to determine whether increased nuclear localization of this enzyme would sensitize the cells to VP-16 and doxorubicin. Several methods were used to block topo IIa nuclear export, including leptomycin B (LMB), ratjadone C (RDC), and a pooled siRNA targeted to the mRNA of the export molecule CRM1. RDC and LMB inhibit CRM1 by covalent modification that prevents CRM1 attachment to its cargo protein. The siRNA to CRM1 mRNA was used to deplete total cellular CRM1 protein. All three methods to block nuclear export were found to be effective, as shown by immunofluorescence microscopy, and Western blot of cytoplasmic extracts. CRM1 specific siRNA produced a 50 to 70% knockdown of CRM1 protein. Three human multiple myeloma cell lines, RPMI-8226, H929 and U266, were treated with RDC, LMB, or siRNA and then exposed to the topo II inhibitors, doxorubicin or VP-16 at high cell densities. Cells in which CRM1 was depleted or blocked were found to be four-fold more sensitive to these drugs as determined by caspase 3 apoptosis assays and mitochondrial membrane potential (flow cytometry). Mechanistic studies determined that cell death was due to increased DNA strand breaks, as shown by the comet assay. In addition, band depletion assays showed that the topo II inhibitors, in combination with CRM1 inhibitors, increased the amount of topo IIa that was covalently bound to DNA. This suggests that topo II inhibitor /CRM1 inhibitor treatment increased the level of cleavable complexes by retaining topo IIa in the nucleus, which would lead to more DNA strand breaks and cell death. Thus, blocking topo IIa nuclear export in high-density myeloma cells sensitizes these cells to topo II inhibitors. This may have clinical implications. Supported in part by NIH grant CA82533.
Bright-field imaging of lattice distortions using x rays (2006)

Can x rays yield bright-field images of crystalline systems similar to those of transmission electron microscopy? So far, the response was negative, but the authors present here a positive case: bright-field x-ray images carrying information both from diffraction/scattering phenomena and from absorption and phase contrast. Specifically, synchrotron x-ray transmission micrographs simultaneously yielded diffraction-based information on strain effects and information on structural inhomogeneities when (0001) 4H-SiC wafers were set for a strong reflection in the Laue geometry. This approach offers interesting advantages with respect to the separate study of strain and inhomogeneity effects for a variety of crystalline systems.
ChemInform Abstract: Cobalt‐Catalyzed Intermolecular C—H Amination with Bromamine‐T as Nitrene Source. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Aerodynamics of a Convex Bump on a Ground-Effect Diffuser (2018)

A ground-effect diffuser is an upward-sloping section of the underbody of a racing car that enhances aerodynamic performance by increasing the downforce, thus improving tire grip. The downforce generated by a diffuser can be increased by geometric modifications that facilitate passive flow control. Here, we modified a bluff body equipped with a 17deg diffuser ramp surface (the baseline/plane diffuser) to introduce a convex bump near the end of the ramp surface. The flow features, force, and surface pressure measurements determined in wind-tunnel experiments agreed with previous studies but the bump favorably altered the overall diffuser pressure recovery curve by increasing the flow velocity near the diffuser exit. This resulted in a static pressure drop near the diffuser exit followed by an increase to freestream static pressure, thus increasing the downforce across most of the ride heights we tested. We observed a maximum 4.9% increase in downforce when the modified diffuser was compared to the plane diffuser. The downforce increment declined as the ride height was gradually reduced to the low-downforce diffuser flow regime.
A multi-IDT input tunable surface acoustic wave filter (2001)

Tunable surface acoustic wave (SAW) filters (TSF) have been widely used in the wireless telecommunication systems. A prototype of a multi-IDT (interdigital transducer) input TSF has been developed. The device consists of 11 IDT paralleled in the SAW propagation path. Different SAW filter configurations are realized by selecting or combining various IDTs, resulting in the tunability of both center frequency and 3 dB bandwidth. The center frequencies of the SAW filter range from 126.8 to 199.1 MHz; the 3 dB bandwidths range from 15.2 to 58.9 MHz. Impedance weighting methods have been applied. The passband ripple has been reduced from 6.44 to 1.37 dB after resistance weighting.