gebhart/patrepeval huggingface dataset:
Empirical Study of E-logistics System Based on Tibet Logistics Industry (2013)

With the rapid growth of E-logistics in the global logistics industry, it is important to get insight into E-logistics system in Chinese logistics industry. Regarding the current situation of E-logistics of Chinese logistics industry, there are still many problems to be concerned and resolved. This paper will review the concepts and theoretical background of E-logistics System from previous researches. After acknowledging the essential issues on E-logistics System, a research model is designed and tested based on the Theory Acceptance Model. This research aims to provide theoretical and practical contributions for Chinese logistics companies to enhance understanding on E-logistics System. It also provides some useful theoretical implication and practical guidelines for the development of E-logistics System in Chinese logistics industry.
Wireless Hand Gesture Controlled Robotic Arm Via NRF24L01 Transceiver (2019)

The wireless hand gesture controlled robotic arm is a wireless system that can convey the information between two or more points and it is not physically connected by any electrical conductors. It will convey movement information from a real person's hand to the robotic arm wirelessly. Some common controllers used to control a robotic arm system include mouse controllers, keyboard controllers, joystick controllers, keypad controllers and so on. Although all of these controllers are the most common controller to control a robotic arm system, there are still some difficulties to use these controllers. The objective is to ease the control of the robotic arm with hand gesture by using flex bend sensors and servo motors for humanitarian aid purposes. Two Arduino NANO is used, one on the real person's hand and the other on the robotic arm as the microcontroller in this project since it is easy to change and the programming language of this microcontroller is more familiar rather than other microcontrollers. A pair of NRF24L01 transceiver module is used for the wireless communication between both Arduino NANO microcontrollers. This project results in a much easier and reliable controlling method of the robotic arm.
CoAP over ICN (2017)

The Constrained Application Protocol (CoAP) is a specialized Web transfer protocol for resource-oriented applications intended to run on constrained devices, typically part of the Internet of Things. In this paper we leverage Information-Centric Networking (ICN), deployed within the domain of a network provider that interconnects, in addition to other terminals, CoAP endpoints in order to provide enhanced CoAP services. We present various CoAP-specific communication scenarios and discuss how ICN can provide benefits to both network providers and CoAP applications, even though the latter are not aware of the existence of ICN. In particular, the use of ICN results in smaller state management complexity at CoAP endpoints, simpler implementation at CoAP endpoints, and less communication overhead in the network.
Forecasting and operational research: a review (2008)

From its foundation, operational research (OR) has made many substantial contributions to practical forecasting in organizations. Equally, researchers in other disciplines have influenced forecasting practice. Since the last survey articles in JORS, forecasting has developed as a discipline with its own journals. While the effect of this increased specialization has been a narrowing of the scope of OR's interest in forecasting, research from an OR perspective remains vigorous. OR has been more receptive than other disciplines to the specialist research published in the forecasting journals, capitalizing on some of their key findings. In this paper, we identify the particular topics of OR interest over the past 25 years. After a brief summary of the current research in forecasting methods, we examine those topic areas that have grabbed the attention of OR researchers: computationally intensive methods and applications in operations and marketing. Applications in operations have proved particularly important, including the management of inventories and the effects of sharing forecast information across the supply chain. The second area of application is marketing, including customer relationship management using data mining and computer-intensive methods. The paper concludes by arguing that the unique contribution that OR can continue to make to forecasting is through developing models that link the effectiveness of new forecasting methods to the organizational context in which the models will be applied. The benefits of examining the system rather than its separate components are likely to be substantial.
Evidence for gene flow via seed dispersal from crop to wild relatives in<i>Beta vulgaris</i>(Chenopodiaceae): consequences for the release of genetically modified crop species with weedy lineages (2003)

Gene flow and introgression from cultivated to wild plant populations have important evolutionary and ecological consequences and require detailed investigations for risk assessments of transgene escape into natural ecosystems. Sugar beets (Beta vulgaris ssp. vulgaris) are of particular concern because: (i) they are cross-compatible with their wild relatives (the sea beet, B. vulgaris ssp. maritima); (ii) crop-to-wild gene flow is likely to occur via weedy lineages resulting from hybridization events and locally infesting fields. Using a chloroplastic marker and a set of nuclear microsatellite loci, the occurrence of crop-to-wild gene flow was investigated in the French sugar beet production area within a 'contact-zone' in between coastal wild populations and sugar beet fields. The results did not reveal large pollen dispersal from weed to wild beets. However, several pieces of evidence clearly show an escape of weedy lineages from fields via seed flow. Since most studies involving the assessment of transgene escape from crops to wild outcrossing relatives generally focused only on pollen dispersal, this last result was unexpected: it points out the key role of a long-lived seed bank and highlights support for transgene escape via man-mediated long-distance dispersal events.
Patterns of Baptist Ministry in the Twentieth Century (1989)

(1989). Patterns of Baptist Ministry in the Twentieth Century. Baptist Quarterly: Vol. 33, No. 2, pp. 81-93.
Conversion of a cyclooxygenase (CO) inhibitor into a 5-lipoxygenase (LO) inhibitor: a general route to novel orally active anti-inflammatory and anti-allergy drugs. (1991)

Previously, the conversion of a CO inhibitor, naproxen, into an orally active 5-LO inhibitor, Wy-50,295, by covalent attachment of a quinoline group was reported. The authors now report the extension of this transformation to other CO inhibitors. Replacement of an existing substituent or a hydrogen in sulindac, etodolac, carprofen, diclofenac, oxaprozin, des-alpha-methyl-ketoprofen, or des-alpha-methyl-flurbiprofen by a methoxyquinoline group afforded new hybrid structures which were orally active 5-LO inhibitors in the rat RPAR (reverse passive Arthus reaction) assay. In contrast to Wy-50,295 which is a selective 5-LO inhibitor, some of these new hybrids were dual inhibitors of 5-LO and CO. For example, the quinoline-etodolac hybrid WAY-120,739, (1,8-diethyl-1,3,4,9-tetrahydro-6-(2-quinolinylmethoxy)pyrano [3,4-b]indole-1-acetic acid) was a dual inhibitor of 5-LO and CO (91% and 47% inhibition, respectively at 10 microM, rat PMN). In contrast, the quinoline-flurbiprofen hybrid WAY-121,006, (3-fluoro-4'-(2-quinolinylmethoxy)-[1,1'-biphenyl]-4-acetic acid), the quinoline-oxaprozin hybrid, WAY-120,460, (5-phenyl-4-[4-(2- quinolinylmethoxy)phenyl]-2-oxazolepropanoic acid) and the quinoline-carprofen hybrid WAY-120,429 (alpha-methyl-6-(2-quinolinylmethoxy)-9-(2-quinolinylmethoxy)-9H- carbazole-2-acetic acid) were purely 5-LO inhibitors (100%, 96% and 92% inhibition of 5-LO at 10 microM, rat PMN, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Functional Rare Earth-Based Micro/Nanomaterials (2018)

This chapter reviews microwave (MW) preparation of functional rare earth (RE)-based micro/nanomaterials including inorganic compounds, coordination polymers (CP), and composite materials. It introduces the properties of functional RE-based micro/nanomaterials and was compared with their corresponding bulk materials. The chapter shows that CPs and the characteristics of RE-based CPs and classifications. It reviews the MW preparation of RE-based coordination polymer and discusses their applications. The chapter also reviews the MW preparation of RE-based composite materials. It summarizes the MW synthesis of RE-based micro/nanomaterials. RE elements contain lanthanide (Ln) elements with atomic number from 57 to 71, and scandium and yttrium, which have similar electronic structures and chemical properties to Ln elements. The typical RE nanomaterials exhibit certain size-insensitive luminescence behaviors, which is different from quantum dots.
CRISPR/Cas9 Mutagenesis and Expression of Dominant Mutant Transgenes as Functional Genomic Approaches in Parasitic Nematodes (2019)

DNA transformation of parasitic nematodes enables novel approaches to validating predictions from genomic and transcriptomic studies of these important pathogens. Notably, proof of principle for CRISPR/Cas9 mutagenesis has been achieved in Strongyloides spp. allowing identification of molecules essential to the functions of sensory neurons that mediate behaviors comprising host finding, invasion and location of predilection sites by parasitic nematodes. Likewise, CRISPR/Cas9 knockout of the developmental regulatory transcription factor Ss-daf-16 has validated its function in regulating morphogenesis of infective third-stage larvae in Strongyloides stercoralis. While encouraging, these studies underscore challenges that remain in achieving straightforward validation of essential intervention targets in parasitic nematodes. Chief among these is the likelihood that knockout of multifunctional regulators like Ss-DAF-16 or its downstream mediator, the nuclear receptor Ss-DAF-12, will produce phenotypes so complex as to defy interpretation and will render affected worms incapable of infecting their hosts, thus preventing establishment of stable mutant lines. Approaches to overcoming these impediments could involve refinements to current CRISPR/Cas9 methods in Strongyloides including regulatable Cas9 expression from integrated transgenes and CRISPR/Cas9 editing to ablate specific functional motifs in regulatory molecules without complete knockout. Another approach would express transgenes encoding regulatory molecules of interest with mutations designed to similarly ablate or degrade specific functional motifs such as the ligand binding domain of Ss-DAF-12, while preserving core functions such as DNA binding. Such mutant transgenes would be expected to exert a dominant interfering effect on their endogenous counterparts. Published reports validate the utility of such dominant-negative approaches in Strongyloides.
A Three‐Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous‐Flow Processing (2014)

In a total residence time of three minutes, ibuprofen was assembled from its elementary building blocks with an average yield of above 90% for each step. A scale-up of this five-stage process (3 bond-forming steps, one work-up, and one in-line liquid-liquid separation) provided ibuprofen at a rate of 8.09 g h(-1) (equivalent to 70.8 kg y(-1)) using a system with an overall footprint of half the size of a standard laboratory fume hood. Aside from the high throughput, several other aspects of this synthesis expand the capabilities of continuous-flow processing, including a Friedel-Crafts acylation run under neat conditions and promoted by AlCl3, an exothermic in-line quench of high concentrations of precipitation-prone AlCl3, liquid-liquid separations run at or above 200 psi to provide solvent-free product, and the use of highly aggressive oxidants, such as iodine monochloride. The use of simple, inexpensive, and readily available reagents thus affords a practical synthesis of this important generic pharmaceutical.
PEG-rIL-10 treatment decreases FoxP3<sup>+</sup>Tregs despite upregulation of intratumoral IDO (2016)

IL-10 has been classically defined as a broad-spectrum immunosuppressant and is thought to facilitate the development of regulatory CD4(+) T cells. IL-10 is believed to represent one of the major suppressive factors secreted by IDO(+)FoxP3(+)CD4(+) Tregs. Contrary to this view, we have previously reported that PEGylated recombinant IL-10 (PEG-rIL-10) treatment of mice induces potent IFNγ and CD8(+) T-cell-dependent antitumor immunity. This hypothesis is currently being tested in clinical trials and we have reported that treatment of cancer patients with PEG-rHuIL-10 results in inhibition and regression of tumor growth as well as increased serum IFNγ. We have continued to assess PEG-rIL-10's pleiotropic effects and report that treatment of tumor-bearing mice and humans with PEG-rIL-10 increases intratumoral indoleamine 2, 3-dioxygenase (IDO) in an IFNγ-dependent manner. This should result in an increase in Tregs, but paradoxically our data illustrate that PEG-rIL-10 treatment of mice reduces intratumoral FoxP3(+)CD4(+) T cells in an IDO-independent manner. Additional investigation indicates that PEG-rIL-10 inhibits TGFβ/IL-2-dependent in vitro polarization of FoxP3(+)CD4(+) Tregs and potentiates IFNγ(+)T-bet(+)CD4(+) T cells. These data suggest that rather than acting as an immunosuppressant, PEG-rIL-10 may counteract the FoxP3(+)CD4(+) Treg suppressive milieu in tumor-bearing mice and humans, thereby further facilitating PEG-rIL-10's potent antitumor immunity.
Electrolytic Partial Fluorination of Organic Compounds. 79. Anodic Fluorination of Spiropyrazoline-5,3‘-chroman-4-ones and Thiochromanone Analogues. A Route to Aroyl Fluoride Derivatives (2005)

[reaction: see text] Anodic fluorination of spiropyrazole-5,3'-chroman-4-ones and their thiochromanone analogues in dimethoxyethane containing Et4NF x 4HF resulted in ring opening of spiroheterocycles, which led to the formation of (5-pyrazolyl)methyl o-carbomethoxyphenyl ethers and their thioether analogues via benzoyl fluoride derivatives.
Chinese text segmentation for text retrieval: Achievements and problems (1993)

Present text retrieval systems are generally built on the reductionist basis that words in texts (keywords) are used as indexing terms to represent the texts. A necessary precursor to these systems is word extraction which, for English texts, can be achieved automatically by using spaces and punctuations as word delimiters. This cannot be readily applied to Chinese texts because they do not have obvious word boundaries. A Chinese text consists of a linear sequence of nonspaced or equally spaced ideographic characters, which are similar to morphemes in English. Researchers of Chinese text retrieval have been seeking methods of text segmentation to divide Chinese texts automatically into words. First, a review of these methods is provided in which the various different approaches to Chinese text segmentation have been classified in order to provide a general picture of the research activity in this area. Some of the most important work is described. There follows a discussion of the problems of Chinese text segmentation with examples to illustrate. These problems include morphological complexities, segmentation ambiguity, and parsing problems, and demonstrate that text segmentation remains one of the most challenging and interesting areas for Chinese text retrieval. © 1993 John Wiley & Sons, Inc.
Tree-based parallel load-balancing methods for solution-adaptive finite element graphs on distributed memory multicomputers (1999)

To solve the load imbalance problem of a solution-adaptive finite element application program on a distributed memory multicomputer, nodes of a refined finite element graph can be remapped to processors or load of a refined finite element graph can be redistributed based on the current load of each processor. For the former case, remapping can be performed by some fast mapping algorithms. For the latter case, a load-balancing algorithm can be applied to balance the computational load of each processor. In this paper, three tree-based parallel load-balancing methods, the MCSTLB method, the BTLB method, and the CBTLB method, were proposed to deal with the load imbalance problems of solution-adaptive finite element application programs. To evaluate the performance of the proposed methods, we have implemented those methods along with three mapping methods, the AE/ORB method, the AE/MC method, and the MLkP method, on an SP2 parallel machine. Three criteria, the execution time of mapping/load-balancing methods, the execution time of a solution-adaptive finite element application program under different mapping/load-balancing methods, and the speedups achieved by mapping/load-balancing methods for a solution-adaptive finite element application program, are used for the performance evaluation. The experimental results show that 1) if the initial mapping is performed by a mapping method and the same mapping method and load-balancing methods were used in each refinement to balance the load of processors, the execution time of an application program under a load-balancing method is always shorter than that of the mapping method, and 2) the execution time of an application program under the CBTLB method is shorter than that of the BTLB method and the MCSTLB method.
Security Challenge and Defense in VoIP Infrastructures (2007)

Voice over Internet protocol (VoIP) has become a popular alternative to traditional public-switched telephone network (PSTN) networks that provides advantages of low cost and flexible advanced ldquodigitalrdquo features. The flexibility of the VoIP system and the convergence of voice and data networks brings with it additional security risks. These are in addition to the common security concerns faced by the underlying IP data network facilities that a VoIP system relies on. The result being that the VoIP network further complicates the security assurance mission faced by enterprises employing this technology. It is time to document various security issues that a VoIP infrastructure may face and analyze the challenges and solutions that may guide future research and development efforts. In this paper, we examine and investigate the concerns and requirements of VoIP security. After a thorough review of security issues and defense mechanisms, we focus on attacks and countermeasures unique to VoIP systems that are essential for current and future VoIP implantations. Then, we analyze two popular industry best practices for securing VoIP networks and conclude this paper with further discussion on future research directions. This paper aims to direct future research efforts and to offer helpful guidelines for practitioners.
Genomic Evolution of Hox Gene Clusters (2006)

The family of Hox genes, which number 4 to 48 per genome depending on the animal, control morphologies on the main body axis of nearly all metazoans. The conventional wisdom is that Hox genes are arranged in chromosomal clusters in colinear order with their expression patterns on the body axis. However, recent evidence has shown that Hox gene clusters are fragmented, reduced, or expanded in many animals-findings that correlate with interesting morphological changes in evolution. Hox gene clusters also contain many noncoding RNAs, such as intergenic regulatory transcripts and evolutionarily conserved microRNAs, some of whose developmental functions have recently been explored.
Changes in the Prevalence of Cerebral Palsy for Children Born Very Prematurely Within a Population-Based Program Over 30 Years (2007)

Population-based CP prevalence rates for children whose gestational age was 20 to 27 weeks and whose birth weight ranged from 500 to 1249 g show steady reductions in the last decade with stable or reducing mortality, reversing trends prior to 1992-1994.
Selective oxidation of carbolide C–H bonds by an engineered macrolide P450 mono-oxygenase (2009)

Regio- and stereoselective oxidation of an unactivated C-H bond remains a central challenge in organic chemistry. Considerable effort has been devoted to identifying transition metal complexes, biological catalysts, or simplified mimics, but limited success has been achieved. Cytochrome P450 mono-oxygenases are involved in diverse types of regio- and stereoselective oxidations, and represent a promising biocatalyst to address this challenge. The application of this class of enzymes is particularly significant if their substrate spectra can be broadened, selectivity controlled, and reactions catalyzed in the absence of expensive heterologous redox partners. In this study, we engineered a macrolide biosynthetic P450 mono-oxygenase PikC (PikC(D50N)-RhFRED) with remarkable substrate flexibility, significantly increased activity compared to wild-type enzyme, and self-sufficiency. By harnessing its unique desosamine-anchoring functionality via a heretofore under-explored "substrate engineering" strategy, we demonstrated the ability of PikC to hydroxylate a series of carbocyclic rings linked to the desosamine glycoside via an acetal linkage (referred to as "carbolides") in a regioselective manner. Complementary analysis of a number of high-resolution enzyme-substrate cocrystal structures provided significant insights into the function of the aminosugar-derived anchoring group for control of reaction site selectivity. Moreover, unexpected biological activity of a select number of these carbolide systems revealed their potential as a previously unrecorded class of antibiotics.
Chameleon (2008)

As computing capabilities of embedded devices increase, services such as Internet and multimedia are comportably supported by such devices. Users may demand for migrating services from one machine to another that can provide better capabilities and convenience in terms of battery stock and input/output (I/O) method. However, I/O devices capabilities between embedded mobile devices and user interaction behavior are particulary different. So, heterogenous I/O capabilities and functions may make migration of computing states between embedded devices virtually impossible. To guarantee seamless I/O state migration between embedded mobile devices, we propose interface virtualization and capability adaptation. In this paper, we describe a system architecture based on Xen virtualization as well as design principles and performance.
Acute and Chronic Effects of Ammonia Burns of the Respiratory Tract (1980)

Exposure to anhydrous ammonia can result in substantial injury to the respiratory system, eyes, and integument. In this retrospective study, we present the acute and chronic respiratory manifestations in 12 patients exposed to anhydrous ammonia as a result of the same accident. Survivors suffering significant ill effects are separated into two groups according to history and clinical course. One group of patients sustained exposure to high concentrations of ammonia over a short period of time. They manifested upper airway obstruction and required early intubation or tracheostomy. These patients recovered with few pulmonary sequelae and are presently in good pulmonary health. The second group of patients were exposed to lower concentrations of gas over a prolonged period of time and did not manifest upper airway obstruction. In this group of patients, however, significant long-term pulmonary sequelae are manifested.