gebhart/patrepeval huggingface dataset:
Neuronal Loss in the Rostral Ventromedial Medulla in a Rat Model of Neuropathic Pain (2011)

Cell death has been reported in the CNS in models of neuropathic pain (Sugimoto et al., 1990; Whiteside and Munglani, 2001; Scholz et al., 2005; Fuccio et al., 2009). In our present study, we examined the effects of spinal nerve ligation (SNL) on the number of neurons in the rostral ventromedial medulla (RVM), a brainstem region involved in modulation of nociception. In rats receiving SNL, we found that the number of RVM neurons decreased by 23% in the side ipsilateral to the surgery. The loss of RVM neurons was also associated with a bilateral increase in the number of glia as well as bilateral activation of both astrocytes and microglia. Administration of tauroursodeoxycholic acid (TUDCA), which reportedly inhibits apoptosis, significantly reduced the loss of neurons, the increase in glia, and the mechanical hypersensitivity induced by SNL. Among RVM neurons, we found that serotonergic (5-hydroxytryptamine, 5-HT) neurons decreased by 35% ipsilateral to SNL. Consistent with these findings, the density of 5-HT-immunoreactive varicosities in the superficial dorsal horn of the spinal cord was 15-30% lower, ipsilateral to SNL. To test the function of the remaining 5-HT neurons, we administered the 5-HT neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT). Interestingly, after 5,7-DHT, mechanical withdrawal thresholds increased significantly. We conclude that nerve injury induces death of antinociceptive RVM neurons that can be reduced or abolished by TUDCA. We propose that the loss of RVM neurons shifts the balance of descending control from pain inhibition to pain facilitation.
Opportunistic relay selection for wireless network coding (2009)

Owing to its potential of enhancing the network performance and to the large number of applications it can be suited for, wireless network coding is attracting a lot of interest from both the academic and the industrial communities. A common assumption in most of the literature is the presence of a single intermediate relay node where the network coding operation takes place. However, in an actual wireless system, a multitude of relaying nodes would exist, thus potentially further improving the performance; but with this the issue of relay selection arises. In this paper we study the performance of network coding in presence of opportunistic relay selection. We conjecture that relay selection schemes should be aware of, and account for, the network coding operation in case of its presence. Based on system level simulation results, it is demonstrated that such an awareness provides considerable capacity gains as compared to its traditional opportunistic counterparts, in addition to increased fairness among the encoded sources.
Intense Pulsed Light Sintering of CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> Solar Cells (2016)

Perovskite solar cells utilizing a two-step deposited CH3NH3PbI3 thin film were rapidly sintered using an intense pulsed light source. For the first time, a heat treatment has shown the capability of sintering methylammonium lead iodide perovskite and creating large crystal sizes approaching 1 μm without sacrificing surface coverage. Solar cells with an average efficiency of 11.5% and a champion device of 12.3% are reported. The methylammonium lead iodide perovskite was subjected to 2000 J of energy in a 2 ms pulse of light generated by a xenon lamp, resulting in temperatures significantly exceeding the degradation temperature of 150 °C. The process opens up new opportunities in the manufacturability of perovskite solar cells by eliminating the rate-limiting annealing step, and makes it possible to envision a continuous roll-to-roll process similar to the printing press used in the newspaper industry.
Wireless Vectorcardiogram system optimization using adaptive signal processing (2014)

We are designing an integrated wireless Vectorcardiogram (iVCG) that is of diagnostic quality, extremely small form factor, and is placed on the chest of the patient. In this paper, we consider the problem of transforming the three VCG component signals to the familiar 12-lead ECG for the convenience of cardiologists. We used an adaptive signal processing technique to obtain an ECG signal from the VCG measurements. The least mean-square (LMS) adaptive algorithm is employed to obtain the optimum 12×3 transformation matrix by minimizing the overall mean-square-error between the reference ECG (that is present during VCG configuration) signal and the ECG signal derived from the VCG. With this capability, the iVCG may become a truly transformative wireless medical device enabling continuous cardiac diagnosis.
Order-Disorder Transitions In Strained Semiconductor Systems (1986)

We describe the observation of a strain-induced order-disorder transition in the alloy layers of a GeSi/Si superlattice and discuss the possible implications of the transition for the opto-electronic properties of this important system.
Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels (2014)

Glutathione (GSH) is a key antioxidant that plays an important neuroprotective role in the brain. Decreased GSH levels are associated with neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Here we show that a diurnal fluctuation of GSH levels is correlated with neuroprotective activity against oxidative stress in dopaminergic cells. In addition, we found that the cysteine transporter excitatory amino acid carrier 1 (EAAC1), which is involved in neuronal GSH synthesis, is negatively regulated by the microRNA miR-96-5p, which exhibits a diurnal rhythm. Blocking miR-96-5p by intracerebroventricular administration of an inhibitor increased the level of EAAC1 as well as that of GSH and had a neuroprotective effect against oxidative stress in the mouse substantia nigra. Our results suggest that the diurnal rhythm of miR-96-5p may play a role in neuroprotection by regulating neuronal GSH levels via EAAC1.
Power Optimizing Control of Multi-Zone Heat Pumps (2018)

We derive a power-optimizing output feedback controller for a multi-zone heat pump that (1) regulates individual zone temperatures, rejecting unknown heat load disturbances, (2) regulates condenser subcooling and (3) the compressor discharge temperature, and (4) minimizes electrical power consumption at steady-state operating conditions. The design is a cascade of a linear inner-loop and a nonlinear outer-loop. The inner-loop is designed for robust disturbance rejection using H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> loop-shaping methods. The outer-loop uses a model of compressor and fan power consumption and a gradient descent feedback to drive the system to its power-minimizing equilibrium for constant values of references and disturbances. The controller uses only temperature measurements for feedback; refrigerant pressure sensors, which are not present in many products for cost reasons, are not required. A proof of exponential stability is provided and preliminary experimental tests demonstrate satisfactory transient responses for a commercial multi-zone heat pump.
Temperature-Sensitive Mutants of Influenza Virus. II. Attenuation of ts Recombinants for Man (1972)

Recombinant viruses were produced that contained the surface H3 antigen of influenza A/Hong Kong/1968 (H3N2) virus and a temperature-sensitive (ts) lesion derived from a ts mutant of influenza A/Great Lakes/1965 (H2N2) virus. Three recombinants, each bearing a genetically distinct ts lesion, were administered intranasally to volunteers who lacked serum neutralizing antibody for the H3 hemagglutinin. The ts recombinants exhibited a decreased virulence for man, but the level of attenuation varied. One of the recombinants, ts-l [E], appeared to possess the degree of attenuation desirable for a virus to be used in a live vaccine. The majority of men who were infected by the ts-l [E] recombinant did not develop symptoms. Those symptoms that did occur were mild. Infection with the ts-l [E]recombinant was extensive enough, however, to stimulate moderate levels of serum and nasal neutralizing antibodies and to induce complete resistance to influenzal disease produced by challenge with a virulent wild-type virus. The ts-l [E] recombinant was genetically stable in man and failed to spread from infected individuals to susceptible cohorts who were in close contact. The use of a ts lesion that imposes a defined and desirable degree of attenuation upon influenza A virus and the transfer of this lesion to new antigenic variants of the virus offer some hope for the rapid development of a live vaccine for containment of pandemic disease.
Polypeptide Multilayer Films (2005)

Research on polypeptide multilayer films, coatings, and microcapsules is located at the intersection of several disciplines: synthetic polymer chemistry and physics, biomaterials science, and nanoscale engineering. The past few years have witnessed considerable growth in each of these areas. Unexplored territory has been found at the borders, and new possibilities for technology development are taking form from technological advances in polypeptide production, sequencing of the human genome, and the nature of peptides themselves. Most envisioned applications of polypeptide multilayers have a biomedical bent. Prospects seem no less positive, however, in fields ranging from food technology to environmental science. This review of the present state of polypeptide multilayer film research covers key points of polypeptides as materials, means of polymer production and film preparation, film characterization methods, focal points of current research in basic science, and the outlook for a few specific applications. In addition, it discusses how the study of polypeptide multilayer films could help to clarify the physical basis of assembly and stability of polyelectrolyte multilayers, and mention is made of similarities to protein folding studies.
Design and Characterization of Heteroleptic Ruthenium Complexes Containing Benzimidazole Ligands for Dye-Sensitized Solar Cells: The Effect of Fluorine Substituents on Photovoltaic Performance (2012)

We designed heteroleptic ruthenium complexes (RD12-RD15) containing fluoro-substituted benzimidazole ligands for dye-sensitized solar cells (DSSCs). These dyes were synthesized according to a typical one-pot procedure with the corresponding ancillary ligands produced in two simple steps; they were prepared into DSSC devices according to the same conditions of fabrication. The eventual devices show a systematic trend of increasing VOC and decreasing JSC with fluorine atoms of increasing number substituted on the ligand. The charge-extraction results show that upward shifts of the TiO2 potential occurred when the fluoro-substituted dyes were sensitized on TiO2 with a systematic trend of shift N719 > RD15 (with 5 F) > RD12 (with 2 F) >RD5 (no F); the intensity-modulated photovoltage spectra indicate that those fluoro substituents retard charge recombination with the electron lifetimes (τR) in the order RD15 > RD12 > RD5 > N719, consistent with the variation of VOC for the systems.
A highly parallel Turbo Product Code decoder without interleaving resource (2008)

This article presents an innovative turbo product code (TPC) decoder architecture without any interleaving resource. This architecture includes a full-parallel SISO decoder able to process n symbols in one clock period. Syntheses show the better efficiency of such an architecture compared with existing previous solutions. Considering a 6-iteration turbo decoder of a (32,26) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> BCH product code, synthetized in a 90 nm CMOS technology, the resulting information throughput is 2.5 Gb/s with an area of 233 Kgates. Finally a second architecture enhancing parallelism rate is described. The information throughput is 33.7 Gb/s while an area estimation gives A=10 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Balanced optical-microwave phase detectors for optoelectronic phase-locked loops (2006)

A balanced optical-microwave phase detector for the extraction of low-jitter, high-power, and drift-free microwave signals from optical pulse trains is presented. The phase detection is based on electro-optic sampling with a differentially biased Sagnac loop. Because the timing information is transferred in the optical domain, the regenerated microwave signal is robust against drifts and photodetector nonlinearities. In a first experimental implementation, 3 fs in-loop relative timing jitter (integrated from 1 Hz to 10 MHz) between a 44 MHz optical pulse train and a 10.225 GHz microwave signal is demonstrated.
Relaxed Half-Stochastic Belief Propagation (2013)

Low-density parity-check codes are attractive for high throughput applications because of their low decoding complexity per bit, but also because all the codeword bits can be decoded in parallel. However, achieving this in a circuit implementation is complicated by the number of wires required to exchange messages between processing nodes. Decoding algorithms that exchange binary messages are interesting for fully-parallel implementations because they can reduce the number and the length of the wires, and increase logic density. This paper introduces the Relaxed Half-Stochastic (RHS) decoding algorithm, a binary message belief propagation (BP) algorithm that achieves a coding gain comparable to the best known BP algorithms that use real-valued messages. We derive the RHS algorithm by starting from the well-known Sum-Product algorithm, and then derive a low-complexity version suitable for circuit implementation. We present extensive simulation results on two standardized codes having different rates and constructions, including low bit error rate results. These simulations show that RHS can converge faster on average than existing state-of-the-art decoding algorithms, leading to improvements in throughput and energy efficiency.
Susceptibility of Human Th17 Cells to Human Immunodeficiency Virus and Their Perturbation during Infection (2010)

Our findings suggest a complex perturbation of Th17 subsets during the course of HIV disease potentially through both direct viral infection and virus indirect mechanisms, such as immune activation.
Deep ultraviolet light‐emitting diodes (2006)

Abstract We report on the development of AlGaN‐based deep UV light emitting diodes (LEDs) with emission wavelengths from 254 to 340 nm, focusing on the improvement of 280 nm LEDs efficiency. Under optimal device structure the UV LEDs efficiency was found to strongly depend on the AlGaN material quality. Milliwatt‐power level LEDs were demonstrated for the 254–340 nm spectral range, and for 280 nm LEDs powers reaching 2.5 mW was achieved at 20 mA DC. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Tissue Oxygenation Measurements using a Non-Contact, Smartphone-based Near-Infrared Optical Device (2020)

A non-contact smartphone based NIR imaging device has been developed to measure 2D spatio-temporal tissue oxygenation maps. Preliminary in-vivo studies demonstrated the ability of this device to observe oxygenation changes in response to occlusion.
Studies on a growth‐inhibitory peptide derived from alpha‐fetoprotein and some analogs (2001)

A 34-amino acid synthetic peptide was derived from the third domain of human alpha-fetoprotein, and the peptide was shown to inhibit estrogen-stimulated growth. Under certain conditions, however, the peptide lost growth-inhibitory activity. A biophysical study of the peptide was undertaken with a goal of obtaining completely reliable preparations. The peptide was studied using gel-filtration column chromatography as a function of peptide concentration and age of solution, and was found to exhibit complex aggregation behaviors. During the early period (0-3 h) after dissolving lyophilized peptide into pH 7.4 buffer, solutions were composed mostly of trimers. At higher peptide concentrations (> or = 3.0 g/L), the trimers aggregated extensively to a large aggregate (minimum size approximately 102 peptides). At 5.0-8.0 g/L, these large aggregates increased in size (up to approximately 146 peptides) until trimers were largely exhausted from solution. During the later times (>3 h) after sample preparation, the trimeric oligomer of the peptide dissociated slowly to form dimers for samples at 0.10-3.0 g/L. After their build-up, a very small number of dimers associated to form hexamers. Disulfide bonds stabilized the dimers as indicated by the conversion of dimers to trimers upon the addition of a reducing agent, and the failure of dimers to form in the presence of reducing agent. Reducing agent did not affect trimer or large aggregate formation. Trimers were found to be active in an assay monitoring inhibition of estrogen-stimulated growth, whereas dimers and large aggregates were inactive. The two cysteines in the peptide were modified to either S-methylcysteine or S-(2-aminoethyl)cysteine, and both derivatives showed significant growth-inhibition activity. A serine analog in which both cysteines were replaced had very different aggregation behavior than the cysteine peptide and lacked its growth inhibitory ability. Peptide aggregation is critically important in establishing the ability of the peptide to inhibit growth and have anticancer activity, but the state of its two cysteines is of little influence.
<i>Aqp1</i> expression in erythroleukemia cells: genetic regulation of glucocorticoid and chemical induction (1997)

The aquaporin-1 (AQP1) water channel protein is expressed in multiple mammalian tissues by several different developmental programs; however, the genetic regulation is undefined. The proximal promoter of mouse Aqp1 contains multiple putative cis-acting regulatory elements, and mouse erythroleukemia (MEL) cells are a well-characterized model for erythroid differentiation. Corticosteroid or dimethyl sulfoxide (DMSO) exposure induces AQP1 protein expression in MEL cells, and transcriptional regulation was investigated by transient transfections with Aqp1 promoter-reporter constructs. Dexamethasone induction is abrogated by deletion of two glucocorticoid response elements -0.5 kilobases (kb) from the transcription initiation site. Mutation of the GATA element at -0.62 kb has no effect, whereas mutation of the CACCC site at -37 bp significantly reduces DMSO-induced promoter activity. Hydroxyurea induces expression of AQP1 protein without acting through the proximal promoter. The MEL cell line is a reproducible erythroid model system for studying transcriptional regulation of the Aqp1 gene while determining the consequences on AQP1 protein biosynthesis.
Sub-Nyquist Radar via Doppler Focusing (2012)

We investigate the problem of a monostatic pulse-Doppler radar transceiver trying to detect targets, sparsely populated in the radar's unambiguous time-frequency region. Several past works employ compressed sensing (CS) algorithms to this type of problem, but either do not address sample rate reduction, impose constraints on the radar transmitter, propose CS recovery methods with prohibitive dictionary size, or perform poorly in noisy conditions. Here we describe a sub-Nyquist sampling and recovery approach called Doppler focusing which addresses all of these problems: it performs low rate sampling and digital processing, imposes no restrictions on the transmitter, and uses a CS dictionary with size which does not increase with increasing number of pulses P. Furthermore, in the presence of noise, Doppler focusing enjoys an SNR increase which scales linearly with P, obtaining good detection performance even at SNRs as low as -25dB. The recovery is based on the Xampling framework, which allows reducing the number of samples needed to accurately represent the signal, directly in the analog-to-digital conversion process. After sampling, the entire digital recovery process is performed on the low rate samples without having to return to the Nyquist rate. Finally, our approach can be implemented in hardware using a previously suggested Xampling prototype.
Ultrashort pulse mode-locking from a normal-dispersion on-chip Kerr frequency comb (2014)

We demonstrate a broadband Kerr frequency comb and mode-locking in a globally-normal-dispersion microresonator. A record short on-chip pulse of 74-fs is directly measured. Supported by analytical theory and numerical modeling, we describe the mode-locking mechanism.
Identification of Bacteria Responsible for Ammonia Oxidation in Freshwater Aquaria (2001)

Culture enrichments and culture-independent molecular methods were employed to identify and confirm the presence of novel ammonia-oxidizing bacteria (AOB) in nitrifying freshwater aquaria. Reactors were seeded with biomass from freshwater nitrifying systems and enriched for AOB under various conditions of ammonia concentration. Surveys of cloned rRNA genes from the enrichments revealed four major strains of AOB which were phylogenetically related to the Nitrosomonas marina cluster, the Nitrosospira cluster, or the Nitrosomonas europaea-Nitrosococcus mobilis cluster of the beta subdivision of the class Proteobacteria. Ammonia concentration in the reactors determined which AOB strain dominated in an enrichment. Oligonucleotide probes and PCR primer sets specific for the four AOB strains were developed and used to confirm the presence of the AOB strains in the enrichments. Enrichments of the AOB strains were added to newly established aquaria to determine their ability to accelerate the establishment of ammonia oxidation. Enrichments containing the Nitrosomonas marina-like AOB strain were most efficient at accelerating ammonia oxidation in newly established aquaria. Furthermore, if the Nitrosomonas marina-like AOB strain was present in the original enrichment, even one with other AOB, only the Nitrosomonas marina-like AOB strain was present in aquaria after nitrification was established. Nitrosomonas marina-like AOB were 2% or less of the cells detected by fluorescence in situ hybridization analysis in aquaria in which nitrification was well established.
Fabrication of nanometer size gaps in a metallic wire (2000)

We present a simple shadow mask method to fabricate electrodes with nanometer scale separation. Metal wires with gaps are made by incorporating multiwall carbon nanotubes or single-wall carbon nanotube (SWNT) bundles into a trilayer electron beam lithography process. The simple, highly controllable, and scaleable method has been used to make gaps with widths between 20 and 100 nm and may be extended to gap sizes of 1 nm. We report electron transport measurements of individual SWNTs bridging nanogaps with electrode spacings of approximately 20 nm. Metallic SWNTs exhibit quantum dot behavior with an 80 meV charging energy and a 20 meV energy level splitting. We observe a strong field effect behavior in short semiconducting SWNT segments, evidence for diffusive electron transport in these samples.