gebhart/patrepeval huggingface dataset:
Dual-Mode Free-Jet Combustor (2017)

The dual-mode free-jet combustor concept, pictured in figure 1, is described. It was introduced in 2010 as a wide- operating-range propulsion device using a novel supersonic free-jet combustion process. The unique feature of the free-jet combustor pictured in figure 1a, is supersonic combustion in an unconfined free-jet that traverses a larger subsonic combustion chamber to a variable nozzle. During this mode of operation, the propulsive stream is not in contact with the combustor walls, and equilibrates to the combustion chamber pressure. To a first order, thermodynamic efficiency is similar to that of a traditional scramjet under the assumption of constant-pressure combustion. Qualitatively, a number of possible benefits to this approach are obvious.
A Rice Functional Transcriptional Activator, RISBZ1, Responsible for Endosperm-specific Expression of Storage Protein Genes through GCN4 Motif (2001)

The GCN4 motif, a cis-element that is highly conserved in the promoters of cereal seed storage protein genes, plays a central role in controlling endosperm-specific expression. This motif is the recognition site for a basic leucine zipper transcriptional factor that belongs to the group of maize Opaque-2 (O2)-like proteins. Five different basic leucine zipper cDNA clones, designated RISBZ1-5, have been isolated from a rice seed cDNA library. The predicted gene products can be divided into two groups based on their amino acid sequences. Although all the RISBZ proteins are able to interact with the GCN4 motif, only RISBZ1 is capable of activating (more than 100-fold expression) the expression of a reporter gene under a minimal promoter fused to a pentamer of the GCN4 motif. Loss-of-function and gain-of-function experiments using the yeast GAL4 DNA binding domain revealed that the proline-rich N-terminal domain (27 amino acids in length) is responsible for transactivation. The RISBZ1 protein is capable of forming homodimers as well as heterodimers with other RISBZ subunit proteins. RISBZ1 gene expression is restricted to the seed, where it precedes the expression of storage protein genes. When the RISBZ1 promoter was transcriptionally fused to the beta-glucuronidase reporter gene and the chimeric gene was introduced into rice, the beta-glucuronidase gene is specifically expressed in aleurone and subaleurone layer of the developing endosperm. These findings suggest that the specific expression of transcriptional activator RISBZ1 gene may determine the endosperm specificity of the storage protein genes.
Electronic Wound Monitoring Using Fabric-Integrated Data Modulation (2020)

We propose a cost-efficient smart textile electronic (textronic) for wound healing assessment. This assessment is done by reflection of the modulated wound-data to the interrogator. The RF modulation of the data is done by a textile-based voltage-controlled oscillator (VCO) that takes the electric signal provided by electrochemical sensing of the uric acid found in the wound fluid. The assessment was done based on a threshold found to be 0.4 mM respect to which the severity or restoration of the damage wound is evaluated. The average sensitivity of this system is 44.67 MHz/mM and the maximum power consumption 0.38 mW. It uses low-cost materials and it is easy to manufacture and use by any patient or medical professional.
Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase (2007)

The design and synthesis of a novel series of potent and cell permeable peptidomimetic inhibitors of the human beta-secretase (BACE) are described. These inhibitors feature a hydroxyethyl secondary amine isostere and a novel aromatic ring replacement for the C-terminus. The crystal structure of BACE in complex with this hydroxyethyl secondary amine isostere inhibitor is also presented.
High Contrast Thermal Conductivity Change in Ni–Mn–In Heusler Alloys near Room Temperature (2019)

Materials with an abrupt transition between a low and a high thermal conductance state at a critical temperature would be useful for thermal regulation applications. Here, the authors report a high contrast reversible thermal conductivity change through the thermally‐induced martensitic transition (MT) in Ni–Mn–In alloys. The authors measure the thermal conductivity of a wide temperature range 130 < T < 530 K using time‐domain thermoreflectance (TDTR). The thermal conductivity of these alloys increases from ≈7.0–8.5 W m −1 K −1 to ≈11.5–13.0 W m −1 K −1 through the MT near 300 K as temperature rises, with a rate of change among the highest yet reported in solid‐state materials with thermally‐induced phase transitions. Based on Hall resistivity measurements, the authors further show that the change of thermal conductivity is dominated by the electronic contribution, which results from a unique carrier mobility change through the MT. Their findings highlight the interplay between the structural disorders and the thermal transport in alloys through solid‐state phase transitions and open a new avenue in the search of high‐performance materials for thermal regulation.
Strapping techniques for permanent magnets (1996)

The magnetic field distortion due to magnetization tolerances, fabrication imperfections, and design alterations can be reduced by inserting into a permanent magnet structure thin straps of high permeability ferromagnetic material that lie along equipotential surfaces of the ideal field of a theoretical design. Numerical results are given for a simple model showing quantitatively the beneficial effect of strapping in improving the quality of the field.
Gene Expression and Cell Cycle Arrest Mediated by Transcription Factor DMP1 Is Antagonized by D-Type Cyclins through a Cyclin-Dependent-Kinase-Independent Mechanism (1998)

A novel 761-amino-acid transcription factor, DMP1, contains a central DNA binding domain that includes three imperfect myb repeats flanked by acidic transactivating domains at the amino and carboxyl termini. D-type cyclins associate with a region of the DMP1 DNA binding domain immediately adjacent to the myb repeats to form heteromeric complexes which detectably interact neither with cyclin-dependent kinase 4 (CDK4) nor with DNA. The segment of D-type cyclins required for its interaction with DMP1 falls outside the "cyclin box," which contains the residues predicted to contact CDK4. Hence, D-type cyclin point mutants that do not interact with CDK4 can still bind to DMP1. Enforced coexpression of either of three D-type cyclins (D1, D2, or D3) with DMP1 in mammalian cells canceled its ability to activate gene expression. This property was not shared by cyclins A, B, C, or H; did not depend upon CDK4 or CDK2 coexpression; was not subverted by a mutation in cyclin D1 that prevents its interaction with CDK4; and was unaffected by inhibitors of CDK4 catalytic activity. Introduction of DMP1 into mouse NIH 3T3 fibroblasts inhibited entry into S phase. Cell cycle arrest depended upon the ability of DMP1 to bind to DNA and to transactivate gene expression and was specifically antagonized by coexpression of D-type cyclins, including a D1 point mutant that does not bind to CDK4. Taken together, these findings suggest that DMP1 induces genes that inhibit S phase entry and that D-type cyclins can override DMP1-mediated growth arrest in a CDK-independent manner.
A comprehensive approach to DRAM power management (2008)

This paper describes a comprehensive approach for using the memory controller to improve DRAM energy efficiency and manage DRAM power. We make three contributions: (1) we describe a simple power-down policy for exploiting low power modes of modern DRAMs; (2) we show how the idea of adaptive history-based memory schedulers can be naturally extended to manage power and energy; and (3) for situations in which additional DRAM power reduction is needed, we present a throttling approach that arbitrarily reduces DRAM activity by delaying the issuance of memory commands. Using detailed microarchitectural simulators of the IBM Power5+ and a DDR2-533 SDRAM, we show that our first two techniques combine to increase DRAM energy efficiency by an average of 18.2%, 21.7%, 46.1%, and 37.1% for the Stream, NAS, SPEC2006fp, and commercial benchmarks, respectively. We also show that our throttling approach provides performance that is within 4.4% of an idealized oracular approach.
Polymerization of lactams, 40. Acceleration of the anionic polymerization of 2‐pyrrolidone (1981)

Abstract The effect of transient cooling of the polymerization mixture on the anionic polymerization of 2‐pyrrolidone initiated with potassium 2‐pyrrolidonate (2‐oxo‐1‐pyrrolidinylpotassium) prepared in situ and activated with N ‐acetyl‐2‐pyrrolidone was investigated. It was found that an increase in conversion and molecular weight is controlled by the time interval between the onset of polymerization and transient cooling of the mixture, unlike an isothermal arrangement of the experiment. The possible mechanism by which the polymerization process is affected is discussed.
Development of a Wireless Coiled Tubing Collar Locator (1999)

Development of a Wireless Coiled Tubing Collar Locator Michael L. Connell; Michael L. Connell Halliburton Energy Services, Inc. Search for other works by this author on: This Site Google Scholar Robert G. Howard; Robert G. Howard Halliburton Energy Services, Inc. Search for other works by this author on: This Site Google Scholar Darrell W. Moore Darrell W. Moore Halliburton Energy Services, Inc. Search for other works by this author on: This Site Google Scholar Paper presented at the SPE Asia Pacific Oil and Gas Conference and Exhibition, Jakarta, Indonesia, April 1999. Paper Number: SPE-54327-MS https://doi.org/10.2118/54327-MS Published: April 20 1999 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Connell, Michael L., Howard, Robert G., and Darrell W. Moore. "Development of a Wireless Coiled Tubing Collar Locator." Paper presented at the SPE Asia Pacific Oil and Gas Conference and Exhibition, Jakarta, Indonesia, April 1999. doi: https://doi.org/10.2118/54327-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Asia Pacific Oil and Gas Conference and Exhibition Search Advanced Search Abstract Achieving proper depth control with coiled tubing has been a problem since the service was introduced, and several improvements have been attempted with limited success. A newly developed tool overcomes depth-control problems by providing accurate depth locations of downhole devices. This tool allows real-time depth indication with standard coiled tubing, and requires no logging cable. Keywords: log output, spe 54327, howard, coiled tubing operations, halliburton energy service, solenoid valve, completion installation and operations, connell, depth control, upstream oil & gas Subjects: Formation Evaluation & Management, Perforating, Open hole/cased hole log analysis, Completion Installation and Operations, Coiled tubing operations, Completion Operations Copyright 1999, Society of Petroleum Engineers You can access this article if you purchase or spend a download.
EZ Encoding: A Class of Irredundant Low Power Codes for Data Address and Multiplexed Address Buses (2002)

In this paper, we introduce a class of irredundant low power encoding techniques for memory address buses. For a data address bus, the proposed encoding techniques make use of two working zones in the memory address space, whereas for a multiplexed data and instruction address bus, up to four working zones can be supported The zones are dynamically updated to increase the saving in switching activity. Our techniques decrease the switching activity of data address and multiplexed address buses by an average of 55% and 77%, respectively, up from 25% and 64% achieved by previous methods.
Abnormal calcium handling by platelets in thrombotic disorders. (1987)

This study presents a quantitative comparison of the free cytoplasmic calcium concentration ([Ca2+]cyt) and the free concentration in the lumen of the dense tubules of the human platelet. The former was measured by the fluorescence of the high affinity indicator quin2 and latter by the fluorescence of chlorotetracycline (CTC). The CTC technique monitors calcium-CTC complex accumulation in the lumen of dense tubules and mitochondria when washed platelets were incubated in 2 mM Ca2+. Resting cytoplasmic and dense tubular Ca2+ concentrations were studied in platelets from patients suffering from venous and arterial thrombosis. Compared with normal controls (0.40 +/- 0.10, n = 54), the values of the calcium-CTC ratios were 0.68 +/- 0.19 (n = 16, p less than 0.005) in venous thrombosis; 0.75 +/- 0.18 (n = 14, p less than 0.005) in cardiovascular accident; 0.84 +/- 0.18 (n = 6, p less than 0.005) in occlusive peripheral vascular diseases; and 0.42 +/- 0.10 (n = 21, p greater than 0.1) in patient controls. The dense tubular Ca2+ levels for both patients and controls were perfectly correlated with the cytoplasmic levels using an equation that assumes that the dense tubular free calcium concentration ([Ca2+]dt) has a second power dependence on [Ca2+]cyt. The abnormal Ca2+ handling of platelets obtained from thrombotic patients could be completely reversed by preincubation with the calcium channel blocker verapamil. These observations suggest that the primary Ca2+ handling defect is the leakage through activated channels in the plasma membrane. The defect and the elevated resting [Ca2+]cyt and [Ca2+]dt are adequate to explain the observation of increased rates of collagen-activated aggregation in the above-mentioned group of patients. The results can be explained by platelets from thrombosis patients being exposed to activating factors in the circulation, resulting in Ca2+ channel activation. Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state." This would bring the platelet closer to its aggregation when aggregation-inducing agents are added. The CTC test is shown to be a useful and convenient means of detecting this abnormality.
ChemInform Abstract: HYDRAZONES OF 3‐FORMYLRIFAMYCIN SV PART 1, HYDRAZONES WITH N‐AMINO‐N′‐SUBSTITUTED PIPERAZINES, SYNTHESIS, ANTIBACTERIAL ACTIVITY AND OTHER BIOLOGICAL PROPERTIES (1975)

Abstract Durch Alkylierung verschiedener N‐Nitrosopiperazine und Reduktion der erhaltenen N‐Nitroso‐N′‐alkylpiperazine wird eine Reihe von N‐Amino‐N′‐alkylpiperazinen (I) hergestellt und mit 3‐Formylrifamycin (II) zu den Hydrazonen (III) umgesetzt.
Abstract 17323: Polyinosinic-Polycytidylic Acid Primes Cardiac Progenitors From Human Induced Pluripotent Stem Cells for Enhanced Cell Therapy and Cardiomyocyte Maturation (2018)

Cardiomyocytes derived from human induced pluripotent stem cells (hiPS-CMs) hold promise for disease modeling, drug discovery, and therapy, but the challenge remains to create mature cardiomyocytes like those found in the adult heart. While groups have increased the maturity of hiPS-CMs in extended culture with electrical, metabolic, and mechanical stimulation, we hypothesized that epigenetic modulation during the formation of cardiac progenitors (hiPS-CPCs) could enhance their capacity to form mature CMs. We found that priming with the innate immune agonist polyinosinic-polycytidylic acid (pIC) decreased cardiac lineage-HDAC expression during the formation of hiPS-CPCs in defined small molecule monolayer differentiation. While both untreated and primed day 5 hiPS-CPCs contained equivalent >80% purity of KDR+PDGRFα+ CPC populations, gene expression studies using RNAseq demonstrated that pIC priming enhanced the early cardiogenic and Notch signaling programs. When both groups were differentiated in basal media, primed hiPS-CPCs gave rise to more mature cardiomyocytes based on larger cell size, increased optical action potential upstroke velocity, greater oxidative metabolism, enhanced sarcomere maturation, and upregulated transcriptional markers of CM maturation including cTnI, cardiac actin, and αMHC. These maturation effects of pIC treatment were blocked by the Notch inhibitor DAPT. Most impressively, primed hiPS-CPCs improved survival as well as myocardial systolic/diastolic function in a mouse model of myocardial infarction (Figure). Conclusion: pIC-primed hiPS-CPCs with the capacity to give rise to hiPS-CMs of enhanced maturation hold promise for improved disease modeling, drug screening and cell therapy.
Quantification of Dormancy—Physiological and Biochemical Approaches (1995)

Quantification of seed dormancy has been achieved by measuring physiological, biochemical, and molecular changes accompanying dormancy release, as well as dormancy development. At the physiological level, dormancy is quantified in terms of stratification time, strength of embryo covering structures, embryo growth potential, responsiveness to light, and to temperatures and other changes. At the biochemical level, dormancy has been related to hormone (abscisic acid, gibberellin, etc.) levels, respiratory activity, and other metabolic functions. At the molecular and cellular level, dormancy has been associated with RNA and protein synthesizing ability and with gene expression. Our recent studies with lettuce seeds using gibberellin biosynthesis inhibitors indicate that the amount of gibberellin produced during seed soak may mediate dormancy release and is quantitatively related to the level of dormancy. Examples of quantifiable changes associated with dormancy will be described. Whether a quantifiable change reflects a causal relationship with dormancy release or development, or is a consequence thereof, will be discussed.
Hydrodynamically controlled Hull cell (1991)

A novel hydrodynamically controlled Hull cell (HCHC) apparatus has been developed. This instrument is a modified rotating cylinder which emulates the performance of a conventional Hull cell
P4-15: High current X-ray source technology for medical imaging (2010)

A novel compact rotating anode X-ray tube with high electron focusing capability of a paired magnetic quadrupole system is presented. The tube offers a high power density even at relatively low tube voltage, where the X-ray flux at a detector behind an object is very limited. Its various focal spot deflection capabilities help to reduce image artifacts, enhance the spatial resolution of the corresponding Computed Tomography system, and enable X-ray beam intensity control and compensation of mechanical distortions of the system.
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia (2011)

Structure-guided optimization of a series of C-5 alkyl substituents led to the discovery of a potent nicotinic acid receptor agonist SCH 900271 (33) with an EC50 of 2 nM in the hu-GPR109a assay. Compound 33 demonstrated good oral bioavailability in all species. Compound 33 exhibited dose-dependent inhibition of plasma free fatty acid (FFA) with 50% FFA reduction at 1.0 mg/kg in fasted male beagle dogs. Compound 33 had no overt signs of flushing at doses up to 10 mg/kg with an improved therapeutic window to flushing as compared to nicotinic acid. Compound 33 was evaluated in human clinical trials.
Fault Detection and Exclusion Using Normalized Solution Separation and Residual Monitoring Methods (2003)

ABSTRACT: To achieve the navigational integrity required for civil aviation use of GPS, the GPS fault detection and exclusion (FDE) function is of considerable importance. In this paper, we propose a new FDE approach for tightly integrated GPS/inertial sensors that combines a normalized solution separation for fault detection and a residual monitoring scheme for fault exclusion. The computation of the detection threshold, the horizontal protection level (HPL), and the horizontal uncertainty level (HUL) is discussed, and simulation results are presented. We also develop an FDE algorithm for snapshot navigation methods based on a normalized solution separation scheme. This topic is of interest not only as a limiting case for the general filter problem, but also from a purely technical perspective. The normalized solution separation method is shown to be equivalent to other snapshot FDE algorithms.
Heap data management for limited local memory (LLM) multi-core processors (2010)

This paper presents a scheme to manage heap data in the local memory present in each core of a limited local memory (LLM) multi-core processor. While it is possible to manage heap data semi-automatically using software cache, managing heap data of a core through software cache may require changing the code of the other threads. Cross thread modifications are difficult to code and debug, and only become more difficult as we scale the number of cores. We propose a semi-automatic, and scalable scheme for heap data management that hides this complexity in a library with a much natural programming interface. Furthermore, for embedded applications, where the maximum heap size can be known at compile time, we propose optimizations on the heap management to significantly improve the application performance. Experiments on several benchmarks of MiBench executing on the Sony Playstation 3 show that our scheme is easier to use, and if we know the maximum size of heap data, then our optimizations can improve application performance by an average of 14%.
STEPS: Predicting place attributes via spatio-temporal analysis (2016)

In recent years, a vast amount of research has been conducted on learning people's interests from their actions. Yet their collective actions also allow us to learn something about the world, in particular, infer attributes of places people visit or interact with. Imagine classifying whether a hotel has a gym or a swimming pool, or whether a restaurant has a romantic atmosphere without ever asking its patrons. Algorithms we present can do just that. Many web applications rely on knowing attributes of places, for instance, whether a particular restaurant has WiFi or offers outdoor seating. Such data can be used to support a range of user experiences, from explicit query-driven search to personalized place recommendations. However, obtaining these attributes is generally difficult, with existing approaches relying on crowdsourcing or parsing online reviews, both of which are noisy, biased, and have limited coverage. Here we present a novel approach to classifying place attributes, which learns from patrons' visit patterns based on anonymous observational data. Our method, STEPS, learns from aggregated sequences of place visits. For example, if many people visit the restaurant on a Saturday evening, coming from a luxury hotel or theater, and stay for a long time, then this restaurant is more likely to have a romantic atmosphere. On the other hand, if most people visit the restaurant on weekdays, coming from work or a grocery store, then the restaurant is less likely to be romantic. We show that such transition features are highly predictive of place attributes. In an extensive empirical evaluation, STEPS nearly doubled the coverage of a state of the art approach thanks to learning from observational location data, which allowed our method to reason about many more places.
Novel implementation of laser heated pedestal growth for the rapid drawing of sapphire fibers (1994)

A new version of laser heated pedestal growth system is described which is amenable for the rapid growth of single crystal fibers. The system incorporates a Gaussian reflector to reshape the radial intensity profile of the CO2 laser beam. When He is used as the growth atmosphere, high optical quality sapphire fibers can be produced at rates as high as 2 cm/min with this apparatus.
ChemInform Abstract: Synthesis of Bicyclic and Polycyclic Alkenes via Palladium‐Catalyzed Intramolecular Arylation and Vinylation. (1988)

Abstract The palladium diacetate‐catalyzed cyclization of vinylic or phenylic iodides containing cycloalkenyl groups is performed under various conditions.