gebhart/patrepeval huggingface dataset:
A Table Look-Up Parser in Online ILTS Applications (2005)

A simple table look-up parser (TLUP) has been developed for parsing and consequently diagnosing syntactic errors in semi-free formatted learners' input sentences of an intelligent language tutoring system (ILTS). The TLUP finds a parse tree for a correct version of an input sentence, diagnoses syntactic errors of the learner by tracing and regarding the deviations of the input from the identified correct sentences as errors of the learner. The TLUP can now display the parse tree as well as diagnosed errors at leaves' level. This simple super-rule based TLUP turns out to be a powerful pedagogic tool coaching L2 (second language) learners on the grammar structures in L2, saving the computing time and running space requirements, improving the parsing accuracy and allowing the real time online running environments to be applicable. The TLUP is effective as long as the input does not deviate too much from anticipated embedded patterns of model answers with committed errors remaining within the framework of anticipation for the level of the ITLS designed. We establish the validity of a TLUP by an (n, c) lot acceptance – sampling plan.
Ontology Mining for Personalized Web Information Gathering (2007)

It is well accepted that ontology is useful for personalized Web information gathering. However, it is challenging to use semantic relations of "kind-of", "part-of", and "related-to" and synthesize commonsense and expert knowledge in a single computational model. In this paper, a personalized ontology model is proposed attempting to answer this challenge. A two-dimensional (Exhaustivity and Specificity) method is also presented to quantitatively analyze these semantic relations in a single framework. The proposals are successfully evaluated by applying the model to a Web information gathering system. The model is a significant contribution to personalized ontology engineering and concept-based Web information gathering in Web Intelligence.
Establishing the Framework to Support Bioartificial Heart Fabrication Using Fibrin‐Based Three‐Dimensional Artificial Heart Muscle (2014)

Only 3000 heart transplants are performed in the USA every year, leaving some 30 000-70 000 Americans without proper care. Current treatment modalities for heart failure have saved many lives yet still do not correct the underlying problems of congestive heart failure. Tissue engineering represents a potential field of study wherein a combination of cells, scaffolds, and/or bioreactors can be utilized to create constructs to mimic, replace, and/or repair defective tissue. The focus of this study was to generate a bioartificial heart (BAH) model using artificial heart muscle (AHM), composed of fibrin gel and neonatal rat cardiac myocytes, and a decellularized scaffold, formed by subjecting an adult rat heart to a series of decellularization solutions. By suturing the AHM around the outside of the decellularized heart and culturing while suspended in media, we were able to retain functional cardiac cells on the scaffold as evinced by visible contractility. Observed contractility rate was correlated with biopotential measurements to confirm essential functionality of cardiac constructs. Cross-sections of the BAH show successful decellularization of the scaffold and contiguous cell-rich AHM around the perimeter of the heart.
Involvement of Human Estrogen Related Receptor Alpha 1 (hERR 1) in Breast Cancer and Hormonally Insensitive Disease (2000)

A plausible candidate for a novel breast cancer prognosticator and target for therapy is the estrogen-related receptor a (ERRalpha), an orphan nuclear receptor that shares significant sequence identity with estrogen receptors (ERs) but does not bind estrogens. The goals of these studies are to asses ERRalpha 5 utility as a novel breast cancer prognosticator and to elucidate ERRalpha's role in modulating estrogen-responsive gene transcription. The data obtained to date indicate that: (i) ERRalpha is itself an estrogen-responsive gene (ii) ERRalpha express ion levels are significantly lower in a small panel of breast carcinomas relative to normal mammary tissues, (iii) the ERRalpha /ERalpha ratio significantly correlates with S-phase fraction and DNA ploidy within the tumors, (iv) ERRalpha represses estrogen-stimulated transcription in MCE-7 cells, (v) ERRalpha may modulate expression of numerous estrogen- responsive genes whose promoters contain identified ERRalpha -binding sites, and (vi) ERRalpha - dependent transcription can be activated through increased c-erbB2 signaling, a gene implicated in tamoxifen resistance. These findings may provide the basis for future studies to determine whether ERRalpha status may indicate sensitivity to hormonal therapies, progression to tamoxifen resistance, and disease outcome.
Molecular investigation of a gene encoding organic solvent‐tolerant alkaline protease from <i>Pseudomonas aeruginosa</i> strain K (2010)

A gene encoding an organic solvent-stable protease was amplified from Pseudomonas aeruginosa strain K by polymerase chain reaction using consensus primers based on multiple sequence alignment of alkaline and metalloprotease genes from Pseudomonas species. The gene, which consisted of 1440 bp nucleotides and deduced 479 amino acid residues, was successfully expressed in pGEX-4T-1 expression system in the presence of 1.0 mM IPTG, after an incubation of 6 h at 37 degrees C. Under these conditions, the recombinant strain K protease was, subsequently, released into the periplasm of E. coli BL21 (DE3) with an optimum proteolytic activity detected at 1.0112 U/ml. To date, this is the first reported expression of alkaline protease (aprA) with such remarkable property in Escherichia coli.
A Room Temperature Method for the Preparation of Ultrathin SiOx Films from Langmuir-Blodgett Layers (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Room Temperature Method for the Preparation of Ultrathin SiOx Films from Langmuir-Blodgett LayersC. L. Mirley and J. T. KobersteinCite this: Langmuir 1995, 11, 4, 1049–1052Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/la00004a001https://doi.org/10.1021/la00004a001research-articleACS PublicationsRequest reuse permissionsArticle Views921Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Granzyme B Activity in Target Cells Detects Attack by Cytotoxic Lymphocytes (2007)

Lymphocyte-mediated cytotoxicity via granule exocytosis operates by the perforin-mediated transfer of granzymes from CTLs and NK cells into target cells where caspase activation and other death pathways are triggered. Granzyme B (GzB) is a major cytotoxic effector in this pathway, and its fate in target cells has been studied by several groups using immunodetection. In this study, we have used a newly developed cell-permeable fluorogenic GzB substrate to measure this protease activity in three different living targets following contact with cytotoxic effectors. Although no GzB activity is measurable in CTL or NK92 effector cells, this activity rapidly becomes detectable throughout the target cytoplasm after effector-target engagement. We have combined the GzB substrate with a second fluorogenic substrate selective for caspase 3 to allow both flow cytometry and fluorescence confocal microscopy studies of cytotoxicity. With both effectors, caspase 3 activity appears subsequent to that of GzB inside all three targets. Overexpression of Bcl-2 in target cells has minimal effects on lysis, NK- or CTL-delivered GzB activity, or activation of target caspase 3. Detection of target GzB activity followed by caspase 3 activation provides a unique readout of a potentially lethal injury delivered by cytotoxic lymphocytes.
The Kinase Activity of Kinase Suppressor of Ras1 (KSR1) Is Independent of Bound MEK (2004)

Kinase Suppressor of Ras1 (KSR1) functions as a positive modulator of Ras-dependent signaling either upstream of or parallel to Raf-1, and pharmacologic inactivation of KSR1 may serve as a treatment for Rasdriven malignancies such as pancreatic cancer (Xing, H. R., Cordon-Cardo, C., Deng, X., Tong, W., Campodonico, L., Fuks, Z., and Kolesnick, R. (2003) Nat. Med. 9, 1266-1268). Although some studies demonstrated a requirement for KSR1 kinase activity for its action, others suggested KSR1 acts primarily as a scaffold facilitating assembly of the c-Raf-1/MEK module. We recently established a two-stage in vitro reconstitution assay to measure KSR1 kinase activity (Xing, H. R., Lozano, J., and Kolesnick, R. (2000) J. Biol. Chem. 275, 17276-17280). In this assay, KSR1, immunopurified to apparent homogeneity, never comes in contact with recombinant kinases other than c-Raf-1. In the first assay stage, activated KSR1 is incubated with recombinant c-Raf-1 and ATP. In the second stage, activated c-Raf-1 is separated from KSR1, and incubated with unactivated MEK1, unactivated MAPK, Elk-1, and ATP. Elk-1 phosphorylation serves as a specific readout for MAPK activation. However, because KSR1 constitutively associates with MEK1 and this interaction appears critical for KSR1 scaffolding function, it has been argued that the kinase activity detected is an artifact of KSR1-bound MEK1. To address these concerns, we depleted as much as 90% of KSR1-bound MEK1 by high salt washing without altering KSR1 kinase activity. Further, a complete inactivation of KSR1-bound MEK1 by pretreating with the MEK inhibitor PD 98059 prior to the first assay stage did not alter KSR1 kinase activity. In addition, the omission of exogenous recombinant GST-MEK1 from the reaction mixture during the second assay stage abolished Elk-1 phosphorylation confirming KSR1-bound MEK1 does not support MAPK activation in our in vitro assay. Moreover, a kinase-inactive mutant, FLAG-Ki-KSR1(D683A/D700A), which efficiently interacts with endogenous MEK1, lacks kinase activity. These results collectively support our contention that the kinase activity of KSR1 is an intrinsic property of this protein independent of KSR1-bound endogenous MEK.
Microscopy characterization of doped fibers (2004)

The use of the Soft X-ray Contact Microscopy technique is discussed as a possible new tool to get information on dopant distribution in the core of single-mode optical fibers with 50 nm spatial resolution.
Tracking human queues using single-point signal monitoring (2014)

We investigate using smartphone WiFi signals to track human queues, which are common in many business areas such as retail stores, airports, and theme parks. Real-time monitoring of such queues would enable a wealth of new applications, such as bottleneck analysis, shift assignments, and dynamic workflow scheduling. We take a minimum infrastructure approach and thus utilize a single monitor placed close to the service area along with transmitting phones. Our strategy extracts unique features embedded in signal traces to infer the critical time points when a person reaches the head of the queue and finishes service, and from these inferences we derive a person's waiting and service times. We develop two approaches in our system, one is directly feature-driven and the second uses a simple Bayesian network. Extensive experiments conducted both in the laboratory as well as in two public facilities demonstrate that our system is robust to real-world environments. We show that in spite of noisy signal readings, our methods can measure service and waiting times to within a $10$ second resolution.
Downlink scheduling in CDMA data networks (2003)

We identify properties of optimal scheduling schemes for downlink traffic in a code division multiple access (CDMA) data-only network. Under idealised assumptions, we show that it is optimal for each base station to transmit to at most one delay-tolerant user at a time. Moreover we prove that a base station, when on, should transmit at maximum power for optimality. For a linear network, we characterise the optimal schedule as the solution to a linear program. As a by-product, our analysis yields bounds on throughput gains obtainable from downlink scheduling.
ONCOLYTIC POLIOVIRUS IMMUNOTHERAPY OF GLIOBLASTOMA (2014)

BACKGROUND: With the exception of Burkitt lymphoma, almost all solid cancers are susceptible to infection with poliovirus, due to widespread ectopic expression of the poliovirus receptor, the onco-fetal cell adhesion molecule Necl5/CD155. We engineered a profoundly CNS-incompetent and genetically stable variant of polio through recombination of the cognate internal ribosomal entry site (IRES) with its counterpart from human rhinovirus type 2. The resulting PVSRIPO chimera is incapable of causing poliomyelitis or encephalitis in non-human primates or human subjects, even after high-dose intracerebral inoculation, but retains excellent cytotoxic properties in malignant cells. This is due to constitutively active signal transduction pathways via Raf-Erk MAPKs to the MAPK-interacting kinase, Mnk, and the translation apparatus. METHODS: Raf-Erk-Mnk signals favor translation of mRNAs with highly structured, encumbered 5' untranslated regions, typical for mRNAs encoding potent biological response modifiers, survival factors, growth factors or oncogenes. They afford an enormous advantage to PVSRIPO translation, causing irreversible lethal cytotoxicity as early as 60 min after infection. PVSRIPO infection of GBM produces drastic, violent cytotoxicity and a wide range of pro-inflammatory and immunogenic host responses. These are due to virally-induced ‘immunogenic cell death’, forceful activation of innate antiviral type 1 interferon responses, non-lethal infection and pro-inflammatory stimulation of tumor-associated macrophages/dendritic cells and stimulation of cytotoxic T-cell responses directed against the tumor. RESULTS: A currently accruing Phase-1 clinical trial of PVSRIPO with intratumoral, CED-mediated infusion in recurrent GBM is showing promise with the first patients experiencing durable complete clinical and near-complete radiographic responses >20 months post PVSRIPO infusion. The key to PVSRIPO oncolytic immunotherapy is the early acute phase of viral cytotoxicity after intratumoral infusion. Unhinged translation control, enabling unfettered viral, IRES-mediated initiation, is independent of the notorious intratumoral and inter-individual heterogeneity of advanced, treatment-refractory cancers. To define the molecular mechanism of PVSRIPO-mediated immunogenic cell death, we unraveled a signaling network centered on Raf-Erk-Mnk signals and their control over the Ser-Arg-rich protein kinase. CONCLUSIONS: Provided a solid mechanistic rationale exists for their use, oncolytic viruses such as PVSRIPO may induce tumor-cytotoxic, immune-modulatory and immune-stimulatory effects with an extent and biological range that are difficult to achieve with any other type of anti-cancer agent. SECONDARY CATEGORY: Preclinical Experimental Therapeutics.
A wide-range phosphor thermometry technique (1998)

Fluorescing materials exhibit a temperature dependence, which may be exploited for thermometry purposes. Solid state materials such as phosphors, glasses and crystals are examples of such and have been used in commercial instruments and various one-of-a- kind research and development applications. This area has been the subject of previous ISA papers. It is generally the case that fluorescence decay time or lifetime is the parameter that is measured in order to determine temperature for applications that do not require imaging. There are several good reasons for this. The decay time is a very sensitive function of temperature. Time- and rate-dependent methods are independent of amplitude fluctuations and are therefore not as susceptible to optical noise. In some applications, however, other aspects of the temperature-dependent fluorescence can also be useful. What follows is a description that concerns intensity-based methods and the types of applications to which they apply. The emphasis of the present work is the advantage for situations demanding a wide range and rapidly varying temperatures.
A Centrifugal Impacter for Damage Susceptibility Evaluation of Shelled Corn (1983)

ABSTRACT A centrifugal impacter for damage susceptibility evaluation of shelled corn was developed. The tester employs a specially designed impeller for accelerating corn kernels toward a smooth cylindrical impact surface. The effects of sample size, feed rate, kernel moisture, and impeller speed on the breakage results were studied using a V factorial experiment. The analysis of results showed that the effects of sample size and feed rate were insignificant in the ranges tested. Corn breakage increased as impeller speed increased or kernel moisture decreased. When compared to the Stein tester, the centrifugal impacter was able to detect damage susceptibility in corn highly resistant to breakage.
Automatic Grammar Augmentation for Robust Voice Command Recognition (2018)

This paper proposes a novel pipeline for automatic grammar augmentation that provides a significant improvement in the voice command recognition accuracy for systems with small footprint acoustic model (AM). The improvement is achieved by augmenting the user-defined voice command set, also called grammar set, with alternate grammar expressions. For a given grammar set, a set of potential grammar expressions (candidate set) for augmentation is constructed from an AM-specific statistical pronunciation dictionary that captures the consistent patterns and errors in the decoding of AM induced by variations in pronunciation, pitch, tempo, accent, ambiguous spellings, and noise conditions. Using this candidate set, greedy optimization based and cross-entropy-method (CEM) based algorithms are considered to search for an augmented grammar set with improved recognition accuracy utilizing a command-specific dataset. Our experiments show that the proposed pipeline along with algorithms considered in this paper significantly reduce the mis-detection and mis-classification rate without increasing the false-alarm rate. Experiments also demonstrate the consistent superior performance of CEM method over greedy-based algorithms.
Nanoparticle Assisted Ultrasound Imaging and Therapy (2019)

A novel idea in using nanoparticle to assist ultrasound for imaging and therapy was pursued. With this approach, both imaging and therapy can be achieved simultaneously. The imaging for tumor was improved and the therapy can have better efficiency in killing cancer cells more than normal cells. Since ultrasound can penetrate deep into human body, it can be used to treat most human cancers.
Mobility enhancement of SSOI devices fabricated with sacrificial thin relaxed SiGe (2005)

NMOS and PMOS devices have been successfully fabricated on SSOI wafers with a 20 nm strained Si layer. The electron and hole mobility enhancements are 115% and 45%, respectively. The SSOI wafer was fabricated by direct wafer bonding with the strained Si on thin SiGe (300 nm) virtual substrate transferred to the oxidized handle wafer by splitting. Strained SiGe depositing H/sub 2//sup +/ implantation, and SiGe lattice relaxation annealing are sequentially performed for the thin SiGe virtual substrate fabrication.
Zone Clusters: A virtual cluster based upon solaris containers (2009)

Virtualization is a powerful technology used primarily for consolidating applications that must be isolated on the same hardware. There are multiple forms of virtualization including both Operating System Virtualization and Virtual Machines. This paper introduces the Zone Cluster, which is a virtual cluster that uses operating system virtualization. Each Zone Cluster node is an operating system virtualization environment on a separate machine, which can be a virtual machine or a physical machine. The paper explains the benefits of Zone Clusters and describes how Zone Clusters were implemented. The paper explores the performance implications of virtualization by reporting file system, network, and application benchmark results for a cluster with no virtualization, zone cluster on physical machines, a cluster on virtual machines, and a zone cluster on virtual machines.
Semantic Interior Mapology: A Toolbox For Indoor Scene Description From\n Architectural Floor Plans (2019)

We introduce the Semantic Interior Mapology (SIM) toolbox for the conversion\nof a floor plan and its room contents (such as furnitures) to a vectorized\nform. The toolbox is composed of the Map Conversion toolkit and the Map\nPopulation toolkit. The Map Conversion toolkit allows one to quickly trace the\nlayout of a floor plan, and to generate a GeoJSON file that can be rendered in\n3D using web applications such as Mapbox. The Map Population toolkit takes the\n3D scan of a room in the building (acquired from an RGB-D camera), and, through\na semi-automatic process, populates individual objects of interest with a\ncorrect dimension and position in the GeoJSON representation of the building.\nSIM is easy to use and produces accurate results even in the case of complex\nbuilding layouts.\n
A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy (2021)

Background The CXCR4 chemokine receptor promotes tumor survival through mechanisms that include suppressing antitumor immune responses. Mavorixafor (X4P-001) is an oral, selective, allosteric CXCR4 inhibitor that decreases the recruitment of immunosuppressive cells into the tumor microenvironment and increases activated cytotoxic Tcell infiltration. Methods Patients with metastatic clear cell renal cell carcinoma (ccRCC) unresponsive to nivolumab monotherapy received oral mavorixafor 400 mg daily plus 240 mg intravenous nivolumab every 2 weeks. Results Nine patients were enrolled, median age 65 years. At baseline 4 had progressive disease (PD) and 5 had stable disease (SD). One of 5 patients with SD at study entry on prior nivolumab monotherapy had a partial response (PR) on combination treatment; all 4 patients with PD at study entry had a best response of SD with the combination treatment (median duration: 6.7 months; range: 3.7-14.7). Four patients discontinued therapy due to treatment-related adverse events (AEs). Grade ≥ 3 drug-related AEs were elevated alanine and aspartate aminotransferase (2 patients each); and autoimmune hepatitis, chronic kidney disease, increased lipase, maculopapular rash, and mucosal inflammation (1 patient each). A robust increase in levels of chemokine (C-X-C motif) ligand 9 CXCL9 on mavorixafor appeared to correlate with clinical benefit. Conclusions The CXCR4 inhibition mediated by mavorixafor, in combination with PD-1 blockade to enhance antitumor immune responses in patients unresponsive to checkpoint inhibitor monotherapy, is worthy of further study. Mavorixafor and nivolumab combination therapy in patients with advanced ccRCC demonstrated potential antitumor activity and a manageable safety profile.Trial registration: ClinicalTrials.gov identifier: NCT02923531. Date of registration: October 04, 2016.