gebhart/patrepeval huggingface dataset:
Building thermal network model and application to temperature regulation (2010)

Residential and commercial facilities account for over 40% of energy consumption in the US. Our work shows how fine grain modeling and sensing of this consumption can lead to substantial savings. We construct a thermal network model of a building with the temperatures of the various rooms as states; with the room thermal capacitances and thermal resistances between the rooms as parameters; the external or ambient temperatures as uncontrolled input and heating and cooling loads as control inputs. We show the effects on energy consumption of the random opening and closing of doors or windows. We show that active management of room temperature set points saves up to 20% of energy costs . We also demonstrate the substantial savings-up to 30%-through strategies of keeping certain doors and windows closed.
Automatic Model Conversion to Modelica for Dymola-based Mechatronic Simulation (2008)

Virtual product development allows us to recognize and evaluate the characteristics of a new product on the basis of simulation at an early stage without hav-ing to build a physical model. Currently the most, widely spread commercial CAE systems do not offer direct support to external dynamic simulation appli-cations. Conversely, dynamic simulation of a de-tailed model is required to maintain good correlation between the behaviour of the real product and its virtual counterpart. In this paper it will be presented, that using a partially automated workflow a conven-ient Modelica model translation can be achieved from the output of a mechanical CAD system, allow-ing the final model to be extended independently with new elements from other simulation domains, considering Dymola-based multi-domain simulation. A.NET-based integrated tool for mechatronic model editing and online / offline visualization support us-ing advanced 3D (and stereo) techniques will also be emphasized in this article.
Virulence-Related Transcriptional Regulators of Streptococcus pyogenes (2016)

Control of virulence gene expression in S. pyogenes is under the charge of 13 two-component regulatory systems and at least 30 transcriptional regulators known thus far. These virulence-related regulators are tasked with integrating environmental host cues with the pathogen’s own metabolic state, as well as feedback signals from the expressed genome, into a coordinated response. This overview of the current understanding of S. pyogenes virulence-related regulators describes their roles in one or multiple of the following categories: Master regulators, such as CovR/S and RofA-like proteins (RALPs), that control the activity of multiple virulence-related regulators; Metabolite-responsive regulators, which sense and respond to changes in availability of sources of energy; carbohydrates (CcpA, Mga), amino acid/nitrogen supplies (Rsh, CodY), and other metabolites S. pyogenes must monitor in the host; Metabolic-control regulators, such as VicR/S, MtsR, CiaH/R, that influence expression of metabolism-related genes to maintain the necessary homeostasis to promote colonization; and Environmental/host immunity-responsive regulators, which control responses to a variety of cues, like oxidative stress (PerR), quorum sensing (Rgg2/3), saliva (SalK/R), and neutrophils (Ihk/Irr). Emphasis is made on the interdependence among regulators and the ways in which variation in their connectivity depends on their genotypic background, likely due to coevolution with its human host.
Indications and positioning of temporary pacing wires (2006)

Atrial and/or ventricular pacing wires are frequently inserted at the end of a cardiac surgical procedure. Their main use is to improve haemodynamic function in the presence of arrhythmias as well as to suppress atrial and ventricular tachyarrhythmias. Their use is generally safe and simple, but infrequent, and rarely catastrophic, complications have been reported.
Silencing of Mouse Hepatic Lanosterol 14-.ALPHA. Demethylase Down-Regulated Plasma Low-Density Lipoprotein Cholesterol Levels by Short-Term Treatment of siRNA (2008)

Cytochrome P450 lanosterol 14-alpha demethylase (CYP51), participated in keeping serum cholesterol homeostasis, is a key enzyme to synthesize cholesterol from lanosterol. Here we focused on investigating the mechanism of CYP51 in modulating serum cholesterol levels in mouse through RNA interference (RNAi). Mice fed on normal or high fat high cholesterol (HFHC) diets were individually treated with small interference RNA (siRNA) of CYP51 gene by tail vein injection. The results showed that administrated single dose of 10 microg CYP51-siRNAs for 48 h resulted in significantly depletion of CYP51 mRNA in liver of mice fed on normal diet (from 40 to 60%, p<0.05). CYP51-siRNAs exerted the inhibition in a dose dependent manner (from 26% in 5 microg to 40% in 20 microg, p<0.05) and most inhibitive effect from day 3 to day 6 (over 50%, p<0.05) after the treatment. Six days after administration of 30 microg CYP51-siRNAs (20 microg on day 0 and 10 microg on day 3), CYP51 mRNA (normal: 50%; HFHC: 70%, p<0.05) and protein levels (normal and HFHC: over 40%, p<0.05) were significantly knocked down in mice liver. Interestingly, low-density lipoprotein receptor (LDLR) expression was significantly elevated compared with controls in hepatic cells after CYP51-siRNAs (mRNA: about 2 times; protein: about 1.6 times, p<0.05). As a consequence, about 50% of sera low-density lipoprotein cholesterol (LDL-ch) were significantly reduced (p<0.05). The effect on LDLR increase and LDL-ch reduction lasted 8 d after a single 20 microg CYP51-siRNAs injection. In addition, CYP51-siRNAs could not cause any fatty liver compared with Buffer-group and did not interfere with mice ovulation. In conclusion, these data demonstrated that CYP51-siRNAs silenced CYP51 in mouse liver and down-regulated plasma LDL-ch levels. The potential mechanism of LDL-ch reduction may be related to up-regulated LDLR expression of hepatic cells. It indicated that there was a cholesterol levels link-modulation system between cholesterol synthetic pathway through CYP51 and cholesterol transport pathway through LDLR in vivo.
Comparison of Systemic Resistance Induced by Avirulent and Nonpathogenic<i>Pseudomonas</i>Species (1996)

The plant growth-promoting rhizobacterium (PGPR) Pseudomonas fluorescens strain WCS417 has been shown to induce systemic resistance against Fusarium oxysporum in several plant species without inducing synthesis of pathogenesis-related proteins (PR). The aim of this study was to establish the spectrum of protection achieved by P fluorescens-mediated induced resistance and to compare its effectiveness with pathogen-mediated systemic acquired resistance, which is associated with necrosis and induction of PR synthesis. We demonstrated that pretreatment with P. fluorescens protects radish (Raphanus sativus) through induction of systemic resistance not only against the fungal root pathogen F. oxysporum f. sp. raphani, but also against the avirulent bacterial leaf pathogen P syringae pv. tomato and the fungal leaf pathogens Alternaria brassicicola and F. oxysporum. We thus demonstrated, for the first time, that one PGPR strain can induce resistance against multiple pathogens. The level of protection was at least as high as that achieved by the necrotizing, PR-inducing P. syringae pv. tomato, and the spectrum was even broader indicating that i) necrosis is not a prerequisite for effective, biological induction of resistance and ii) the absence of PR after induction by P. fluorescens does not lower the level of protection.
Motion-consistent video inpainting (2017)

We propose a fast and automatic inpainting technique for high-definition videos which works under many challenging conditions such as a moving camera, a dynamic background or a long lasting occlusion. Built upon the previous work by Newson et al. [1] which optimizes a global patch-based function, our method makes a significant improvement, especially in motion preservation, by incorporating the optical flow in several stages of the algorithm. Moreover, code parallelization and a modification in the process of patches pairwise matching yield a significant reduction of computation time. Experimental results on both classical and challenging datasets show that our algorithm outperforms other state-of-the-art approaches.
A leverage theory of reputation building with co-branding: Complementarity in reputation building (2007)

We present a leverage theory of reputation building with co-branding. We show\nthat under certain conditions, co-branding that links unknown firms in a new sector\nwith established firms in a mature sector allows the unknown firms to signal a high\nproduct quality and establish their own reputation. We compare this situation\nwith a benchmark in which both sectors are new and firms signal their quality\nonly with prices. We investigate how this comparison is affected by the nature of\nthe technology linking the two sectors and a cross-sector inference problem that\nconsumers might face in identifying the true cause of product failure. We find that\nco-branding facilitates the process in which a Þrm in the new sector to signal its\nproduct quality only if the co-branding sectors produce complementary inputs and\nconsumers face a cross-sector inference problem. We apply our insight to economics\nof superstars, multinational firms and co-authorship.
Digital innovation strategy: A framework for diagnosing and improving digital product and service innovation (2014)

Digital technology is increasingly important in achieving business goals, and its pervasive effects have resulted in the radical restructuring of entire industries. Consequently, managers’ extensive interest in handling digital innovation is not surprising. Recent research has illustrated how digital technologies give rise to a vast potential for product and service innovation that is difficult to control and predict. Therefore, firms need dynamic tools to support themselves in managing the new types of digital innovation processes that emerge. The nature of these processes forces firms to challenge prior assumptions about their product and service portfolio, their digital environment, and ways of organizing innovation work. In this article, we present a managerial framework that supports firms in this undertaking. The framework, geared at supporting ongoing improvements in digital innovation management, covers five key areas: user experience, value proposition, digital evolution scanning, skills, and improvisation. We also present a diagnostic tool that can be utilized as firms begin the process of implementing the framework. Finally, we conclude with our thoughts on the managerial implications of the framework when going forward in a rapidly changing digital innovation landscape.
Identification and growth characteristics of alkalophilic Corynebacterium sp. which produces NAD(P)-dependent maltose dehydrogenase and glucose dehydrogenase. (1980)

An alkalophilic bacterium, strain No. 93-1, was isolated from soil. On the basis of the morphological and biochemical characteristics, this strain was identified to belong to the genus Corynebacterium. A crude extract of this strain showed NAD-dependent dehydro-genase activity on maltose (NAD-MalDH) and glucose (GlcDH). The ratio between these two dehydrogenase activities varied by cultural conditions. And NADP was also a suitable co-factor for dehydrogenase activity on maltose (NADP-MalDH). There were remarkable differences in an optimal temperature and pH stability among these three activities. According to these experimental results, we expected that, at least, three kinds of NAD (P)-dependent dehydrogenase acted on maltose and glucose in the crude extract of this microorganism.
Design of strain-free-fiber with nonuniform dopant concentration for stimulated Brillouin scattering suppression (1993)

The loss and dispersion properties of fibers with a nonuniform dopant concentration along their length are investigated theoretically and simple equations are obtained for loss and dispersion estimation. These equations are used to discuss fiber properties and a design procedure by which to achieve SBS suppression. The loss increases by 0.02-0.03 dB/km/% and the dispersion decreases by -2.4 ps/km/nm/% as the relative-index change due to dopant increases longitudinally. It is found that a large change in the dopant concentration along a fiber is effective in suppressing SBS.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Gang membership: Opportunity, poverty and rebelliousness (1997)

Criminal gangs continue to puzzle our elected officials and society seems powerless to do anything about them. Most efforts to combat gangs are directed at hiring more police officers and pass more laws that allow prosecutors and judges to send gangsters off to prison for longer periods of time.
Bulk Superconductivity up to 122 K in the Tl-Pb-Sr-Ca-Cu-O System (1988)

New high-temperature superconductors based on oxides of thallium and copper, but not containing barium, have been prepared. A transition temperature (T(c)) of about 85 K is found for (Tl(0.5)Pb(0.5)) Sr(2)CaCu(2)O(7) whereas (Tl(0.5)Pb(0.5))Sr(2)Ca(2)Cu(3)O(9) has a T(c) of about 120 K. Both materials possess tetragonal symmetry with a = 3.80 A, c = 12.05 A for (Tl(0.5)Pb(0.5))Sr(2)CaCu(2)O(7), and a = 3.81 A, c = 15.23 A for (Tl(0.5)Pb(0.5))Sr(2)Ca(2)Cu(3)O(9). A structure refinement of the latter phase has been carried out with single-crystal x-ray diffraction data.
Feasible evaluations of coupled multilayer chip inductor for POL converter (2014)

Point of load (POL) converters are required smaller size and high efficiency performance in IT industrial applications, etc. Interleaved technique, magnetic integration techniques and application of GaNFETs are well known as good approaches to satisfy these demands. Although coupled inductors for POL converters have been proposed in several studies, a coupled multilayer chip inductor has not examined because of the difficulty of its construction. In this paper, a novel coupled multilayer chip inductor for interleaved POL converters is proposed. This novel coupled inductor has a winding pair with inversely coupled in the magnetic core. Further, magnetic material of the coupled inductor is Fe-based metal composite powder (Fe-Si-Cr). In addition, Fe-based powder in the magnetic core has been processed electrical insulation by highly crystallized oxide nano-layer in order to reduce eddy-current losses. Its high efficiency performance is evaluated by interleaved step down chopper circuit prototype using normally off typed GaNFETs with 1MHz switching frequency.
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies (2022)

The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion. Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that bind to all human-infecting coronavirus spike proteins from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune donors. These mAbs recognize the fusion peptide and acquire affinity and breadth through somatic mutations. Despite targeting a conserved motif, only some mAbs show broad neutralizing activity in vitro against alpha- and betacoronaviruses, including animal coronaviruses WIV-1 and PDF-2180. Two selected mAbs also neutralize Omicron BA.1 and BA.2 authentic viruses and reduce viral burden and pathology in vivo. Structural and functional analyses showed that the fusion peptide-specific mAbs bound with different modalities to a cryptic epitope hidden in prefusion stabilized spike, which became exposed upon binding of angiotensin-converting enzyme 2 (ACE2) or ACE2-mimicking mAbs.
Contributors, Jul. 1977 (1977)

Presents a biographical entry for each author and co-author included in this issue of the publication.
InAsSb/AlAsSb double-heterostructure and InAsSb/InAlAs quantum-well diode lasers emitting at ∼4 μm (2002)

Studies InAsSb/AlAsSb double-heterostructure lasers emitting at 3.9 /spl mu/m which operated pulsed up to 170 K and CW up to 105 K, with CW power of 30 mW at 70 K. InAsSb/InAlAs quantum-well lasers emitting at 4.5 /spl mu/m operated pulsed up to 85 K.
Un système multi-agent pour la simulation des dynamiques urbaines. (2010)

Simulating the evolution of cities suggests the ability to understand and model the laws governing urban dynamics. The approach presented in this paper uses a multi-agent system to model the self-organising properties of urban systems and aims at providing a tool to study the evolutions of the modelled system. The proposed multi-agent system is a hierarchy of topographic agents (e.g. buildings, roads, rivers or urban blocks) that are built, modified, merged, split, restructured and destroyed over time. Each agent’s behaviour is controlled by a set of evolution rules, constraints and associated ac-
An introduction to the IPEM Toolbox for Perception-Based Music Analysis. (2001)

The motivation for developing a toolbox for perception-based music analysis starts from the observation that much of the world music production (seen over different cultures and time periods) has no score representation, and that if a score representation is available, it still represents but a small percentage of what musical communication really is about. A sonological analysis of musical sounds may provide steps towards a better understanding of the components that contribute to musical information processing but is also insufficient in view of how humans deal with musical signals. Technology has revolutionized our conception of what kind of music research will be possible in the 21st Century. But it is the task of musicologists, in collaboration with other scientists, such as engineers, psychologists, and brain scientists, to make these dreams more concrete. Our basic motivation for developing this toolbox is a pragmatic one: if the musicology aims at understanding music as a social and cultural phenomenon embedded in the physical world and mediated through human faculties of perception, cognition, and processing of expressive communication, then new tools must be developed that allow a fully integrated approach. This paper introduces the main concepts and a state-of-the-art of the modules of the IPEM toolbox for perception-based music analysis. This toolbox represents a bottom-up approach to musical description taking human perception as the basis for musical feature extraction and higher-level conceptualization and representation. The IPEM toolbox provides a collection of MATLAB functions that allow dealing with different aspects of feature extraction as well as a global concept concerning perception-based music analysis. First we present the global internal representation framework. Then we sketch what we have in mind as a global picture and present the modules currently involved. Finally we describe some applications of the toolbox.
MODEL KOMUNIKASI DAKWAH DALAM KONSELING REALITAS BERBASIS A L - H I K M A H: Analisis Terhadap Dialog Verbal dalam Menangani Prilaku Tren LGBT Pada Remaja di Aceh Tamiang (2018)

Komunikasi dakwah dalam konseling realitas berbasis al-hikmah merupakan suatu bentuk komunikasi konseling yang khas dimana seseorang konselor melakukan konseling realitas dengan memadukan nasehat-nasehat yang bersumber sesuai dengan ajaran Alquran dan Sunah dengan pendekatan al-hikmah. Di dalam konseling realitas berbasis al–hikmah ini tidak sekedar membantu individu atau kelompok menyelesaikan masalah kehidupan saja, namun di dalamnya juga memuat tujuan menguatkan dimensi pikiran, emosi dan spiritual-relijius agar terjadinya perubahan tingkah laku. Untuk itu, tulisan ini merupakan hasil analisis terhadap model komunikasi dakwah berbentuk dialog verbal dalam konseling realitas berbasis al-hikmah dalam menanggani prilaku tren LGBT pada remaja di kabupaten Aceh Tamiang. Penulis menemukan bahwa dalam tehnik konseling realitas berbasis al-hikmah ini konselor melakukan prosedur dan tahap-tahap konseling dengan mengunakan pendekatan model komunikasi dakwah dalam bentuk dialog verbal. Pendekatan model komunikasi dakwah yang dimaksud terutama dalam penggunaan bahasa verbal berbasis al-hikmah sebagai alat komunikasi ketika melakukan proses konseling. Hal tersebut karena kegiatan konseling melalui penggunaan bahasa verbal menjadi penentu dalam efektivitas terselesainya suatu permasalahan yang dialami konseli.
Synthesis and Grafting of Thioctic Acid−PEG−Folate Conjugates onto Au Nanoparticles for Selective Targeting of Folate Receptor-Positive Tumor Cells (2006)

This paper reports the creation of Au nanoparticles (AuNP) that are soluble in aqueous solution over a broad range of pH and ionic strength values and that are capable of selective uptake by folate receptor positive (FR+) cancer cells. A novel poly(ethylene glycol) (PEG) construct with thioctic acid and folic acid coupled on opposite ends of the polymer chain was synthesized for targeting the AuNP to FR+ tumor cells via receptor-mediated endocytosis. These folic acid-PEG-thioctic acid conjugates were grafted onto 10-nm-diameter Au particles in aqueous solution. The resulting folate-PEG-coated nanoparticles do not aggregate over a pH range of from 2 to 12 and at electrolyte concentrations of up to 0.5 M NaCl with particle concentrations as high as 1.5 x 10(13) particles/mL. Transmission electron microscopy was used to document the performance of these coated nanoparticles in cell culture. Selective uptake of folate-PEG grafted AuNPs by KB cells, a FR+ cell line that overexpress the folate receptor, was observed. AuNP uptake was minimal in cells that (1) do not overexpress the folate receptor, (2) were exposed to AuNP lacking the folate-PEG conjugate, or (3) were co-incubated with free folic acid in large excess relative to the folate-PEG grafted AuNP. Understanding this process is an important step in the development of methods that use targeted metal nanoparticles for tumor imaging and ablation.
Enhancement of liver-directed transgene expression at initial and repeat doses of AAV vectors admixed with ImmTOR nanoparticles (2021)

Systemic AAV (adeno-associated virus) gene therapy is a promising approach for the treatment of inborn errors of metabolism, but questions remain regarding its potency and durability. Tolerogenic ImmTOR nanoparticles encapsulating rapamycin have been shown to block the formation of neutralizing anti-capsid antibodies, thereby enabling vector re-administration. Here, we further demonstrate that ImmTOR admixed with AAV vectors also enhances hepatic transgene expression at the initial dose of AAV vector, independent of its effects on adaptive immunity. ImmTOR enhances AAV trafficking to the liver, resulting in increased hepatic vector copy numbers and transgene mRNA expression. Enhanced transgene expression occurs through a mechanism independent of the AAV receptor and cannot be replicated in vivo with free rapamycin or empty nanoparticles. The multipronged mechanism of ImmTOR action makes it an attractive candidate to enable more efficient transgene expression at first dose while simultaneously inhibiting adaptive responses against AAV to enable repeat dosing.
Risco de contaminação do corante azul de tripano após primeira utilização (2006)

Under this study's conditions there was no contamination of the bottles stored in cabinets and 1 bottle (10%) stored in the refrigerator showed contamination after opening and initial use. The source of contamination may possibly be the outer part of the product. TB does not show bactericidal and bacteriostatic properties against the tested bacteria and in the applied concentration.