gebhart/patrepeval huggingface dataset:
Rough surfaces (1985)

It has been tacitly assumed so far in this book that the surfaces of contacting bodies are topographically smooth; that the actual surfaces follow precisely the gently curving nominal profiles discussed in Chapters 1 and 4. In consequence contact between them is continuous within the nominal contact area and absent outside it. In reality such circumstances are extremely rare. Mica can be cleaved along atomic planes to give an atomically smooth surface and two such surfaces have been used to obtain perfect contact under laboratory conditions. The asperities on the surface of very compliant solids such as soft rubber, if sufficiently small, may be squashed flat elastically by the contact pressure, so that perfect contact is obtained throughout the nominal contact area. In general, however, contact between solid surfaces is discontinuous and the real area of contact is a small fraction of the nominal contact area. Nor is it easy to flatten initially rough surfaces by plastic deformation of the asperities. For example the serrations produced by a lathe tool in the nominally flat ends of a ductile compression specimen will be crushed plastically by the hard flat platens of the testing machine. They will behave like plastic wedges (§6.2(c)) and deform plastically at a contact pressure ≈3Y where Y is the yield strength of the material. The specimen as a whole will yield in bulk at a nominal pressure of Y.
<i>Mahogany</i> ( <i>mg</i> ) stimulates feeding and increases basal metabolic rate independent of its suppression of <i>agouti</i> (1998)

The mahogany (mg) locus originally was identified as a recessive suppressor of agouti, a locus encoding a skin peptide that modifies coat color by antagonizing the melanocyte-stimulating hormone receptor or MC1-R. Certain dominant alleles of agouti cause an obesity syndrome when ectopic expression of the peptide aberrantly antagonizes the MC4-R, a related melanocyte-stimulating hormone receptor expressed in hypothalamic circuitry and involved in the regulation of feeding behavior and metabolism. Recent work has demonstrated that mg, when homozygous, blocks not only the ability of agouti to induce a yellow coat color when expressed in the skin of the lethal yellow mouse (AY), but also the obesity resulting from ectopic expression of agouti in the brain. Detailed analysis of mg/mg AY/a animals, presented here, demonstrates that mg/mg blocks the obesity, hyperinsulinemia, and increased linear growth induced by ectopic expression of the agouti peptide. Remarkably, however, mg/mg did not reduce hyperphagia in the AY/a mouse. Furthermore, mg/mg induced hyperphagia and an increase in basal metabolic rate in the C57BL/6J mouse in the absence of AY. Consequently, although mahogany is broadly required for agouti peptide action, it also appears to be involved in the control of metabolic rate and feeding behavior independent of its suppression of agouti.
Kinetics of insulin receptor transit to and removal from the plasma membrane. (1983)

The heavy isotope density shift method, in combination with a procedure for labeling cell surface insulin receptors, was used to determine the rate of transit of receptor to the cell surface from their site of synthesis and to follow the net rate of receptor removal from the plasma membrane in 3T3-L1 adipocytes. To label surface receptors, 125I-insulin was bound to cells at 4 degrees C and then covalently cross-linked to the receptors with disuccinimidyl suberate. The identity of the surface-labeled product as insulin receptor was established by immunoprecipitation with antireceptor antibody and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Fully differentiated 3T3-L1 adipocytes were shifted to medium containing heavy (greater than 95% 15N, 13C and 2H) amino acids. The rates of appearance of newly synthesized heavy receptor at the cell surface and the loss of previously synthesized light receptor from the cell surface were followed by resolving labeled heavy and light surface receptors in CsCl density gradients and quantitating labeled receptor subunits by gel electrophoresis. It was shown that 2.5-3.0 h are required for newly synthesized insulin receptor to reach and become functional in the plasma membrane. Insulin-induced down-regulation of cellular insulin receptor level had no effect on the time required for the newly synthesized receptors to reach the cell surface. Down-regulation, however, increased the first order rate constants for the inactivation of cell surface insulin receptors from 0.046 to 0.10 h-1. The fact that the rate constants for inactivation of cell surface and total cellular insulin receptors were identical in the up-regulated state (0.046 and 0.044 h-1, respectively) or in the down-regulated state (0.10 and 0.096 h-1, respectively) suggests that the rate-limiting step in the receptor inactivation pathway occurs at the cell surface.
Modelling and forecasting electricity consumption of Malaysian large steel mills (2011)

This paper describes a model to forecast the daily maximum demand of Malaysian large steel mills and the annual maximum demand contributed by these steel mills. This study attempts to combine both the top-down and bottom-up approaches to forecast the daily and annual maximum demand of the steel mills. The top-down approach uses regression analysis to forecast the annual amount of electricity consumption of the steel mills. The bottom-up approach uses the Model for Analysis of Electric Demand_Electric Load (MAED_EL) to convert the annual steel mills electricity consumption (which was earlier obtained from the regression model) into hourly load of the steel mills. The proposed method shows good forecasting accuracy, with weekly Mean Absolute Percentage Error (MAPE) of 2.3%.
Design and Optimization of Electrically Injected InP-Based Microdisk Lasers Integrated on and Coupled to a SOI Waveguide Circuit (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We have performed a numerical study involving the design and optimization of InP-based microdisk lasers integrated on and coupled to a nanophotonic silicon-on-insulator (SOI) waveguide circuit, fabricated through bonding technology. The theoretical model was tested by fitting it to the lasing characteristics obtained for fabricated devices, which we presented previously. A good fit was obtained using parameter values that are consistent with numerical simulation. To obtain optimized laser performance, the composition of the InP-based epitaxial layer structure was optimized to minimize internal optical loss for a structure compatible with efficient current injection. Specific attention was paid to a tunnel-junction based approach. Bending loss was quantified to estimate the minimum microdisk diameter. The coupling between the InP microdisk and Si waveguide was calculated as function of the bonding layer thickness, waveguide offset and waveguide width. To study the lateral injection efficiency, an equivalent electrical network was solved and the voltage-current characteristic was calculated. Based on these results, the dominant device parameters were identified, including microdisk thickness and radius, coupling loss and tunnel-junction p-type doping. These parameters were optimized to obtain maximum wall-plug efficiency, for output powers in the range 1–100 <formula formulatype="inline"> <tex>$\mu$</tex></formula>W. The results of this optimization illustrate the potential for substantial improvement in laser performance. </para>
Electrical Impedance Spectroscopy of Benign and Malignant Prostatic Tissues (2008)

The electrical properties of benign and malignant prostate tissues differ significantly. This should be considered for use as a diagnostic tool. The differences observed between cancer and benign prostatic hyperplasia are especially important since current screening methods do not reliably differentiate between the 2 conditions.
Clinical Usefulness of Red Cells Preserved in Protein-Poor Mediums (1978)

Blood is normally collected into a combined anticoagulating and preserving medium. We performed a study to ascertain whether improvements could be made by separation of these two functions. Addition of saline-adenine-glucose solutions (40 to 100 ml per blood unit) to buffy-coat-poor red-cell concentrates allowed storage for as long as 35 days with 24-hour erythrocyte post-transfusion survival of 83 +/- 6.8 per cent (+/0 S.D.). Potassium leakage was lower, and in vitro hemolysis somewhat higher than that of whole blood. The microaggregate content after 21 days was 16 per cent of that in whole blood. In over-pressure transfusions the flow rate of red cells was the same with red-cell concentrates to which 80 to 100 ml of suspension medium had been added (hematocrit less than or equal to 60 per cent) as with whole blood. Removal of the buffy coat was essential to reduce hemolysis. We conclude that red cells can be successfully stored in a simple protein-poor medium.
A short-term sublethal in situ toxicity assay with <i>hediste diversicolor</i> (polychaeta) for estuarine sediments based on postexposure feeding (2005)

This study evaluated a short-term sublethal endpoint for in situ toxicity assays for estuarine sediments, based on postexposure feeding of the polychaete Hediste (Nereis) diversicolor Müller. A method for precisely quantifying postexposure feeding rates of H. diversicolor was established under laboratory conditions using Artemia franciscana Kellog nauplii. The sensitivity of the postexposure feeding response to copper was investigated by comparing postexposure feeding rates to growth and lethality. The 48-h and 96-h median lethal concentration (LC50) of copper were 241 and 125 microg/L, respectively, whereas the 48-h median inhibitory concentration (IC50) for postexposure feeding and the 20-d IC50 for growth were 52 and 25 microg/L of copper, respectively. The influence of different exposure conditions (substrate, temperature, salinity, food availability, and light) on H. diversicolor postexposure feeding was assessed; temperature and salinity were found to influence significantly postexposure feeding. The effectiveness of the proposed in situ assay was investigated by deploying it at two reference and six contaminated Portuguese estuaries. A 48-h exposure period was followed by a 1-h postexposure feeding period. High organism recoveries (89-100%) were obtained. Postexposure feeding was depressed significantly (17-90%) at all contaminated sites relatively to reference sites. The proposed in situ assay with H. diversicolor was shown to be a potential useful tool for estuarine sediment toxicity testing.
Synthesis and characterization of hydroxyethyl methacrylate/acrylamide responsive hydrogels (2005)

Abstract Hydrogels based on an aqueous solution of hydroxyethyl methacrylate (HEMA) and acrylamide (AM) in the presence of trithioglycolic acid (TTGA) were prepared under the effect of gamma irradiation. These hydrogels were characterized by IR spectroscopy and thermogravimetric analysis and investigated for temperature‐ and pH‐responsive materials. It was found that TTGA is essential for the formation of HEMA/AM hydrogels at different compositions, in which the gel fraction depends on composition. A binary mixture of HEMA and AM at equal ratios was the critical composition that forms hydrogels, even in the presence of TTGA. The IR spectroscopic analysis showed that the formation of hydrogels depends on hydrogen bonding and crosslinking. The TGA investigations with respect to mass loss and the temperatures of the maximum value of the rate of reaction showed that HEMA/AM hydrogels possess higher thermal stability than that of pure HEMA and this stability increases with increasing ratio of the AM component. Also, it was observed that the temperature of the maximum value of the rate of thermal decomposition reaction depends on hydrogel composition. However, calculations of the activation energy showed that the hydrogel composed of 90% HEMA and 10% AM exhibits the highest thermal stability during the increasing or decreasing rate of reaction. Kinetic studies of swelling in water showed that HEMA/AM hydrogels displayed a temperature‐responsive character within the temperature range 25–30°C, and showed a stepwise swelling behavior in the pH range 2–10, depending on composition. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 95: 1105–1115, 2005
Abstract 6371: Gaseous nitric oxide at high concentration is a powerful anti-tumor agent both in-vitro and in-vivo (2020)

Abstract Nitric Oxide (NO) acts as a signaling molecule in the body in different pathologic conditions, including cancer. Beyond Air is developing an innovative gaseous Nitric Oxide (gNO) based tumor ablation method. The highly diffusible nature of NO may ease its spreading inside the tumor, while its short half-life may limit its effect to the tumor site and not affect the surrounding area. According to our preliminary data, exposure of gNO at 10,000-50,000ppm for a very short time (in some cases one minute or less) efficiently eradicates breast, colon, lung and prostate cancers and shows a potent mouse tumor's destruction in-vivo. Methods: Mouse colon and breast cancer cell lines were exposed to gNO at 150-50,000 ppm for 10 seconds - 180 seconds. Cell viability was examined 24hrs later by XTT assay. Mouse colon tumors were treated by gNO at 10,000ppm - 50,000ppm intratumorally by hypodermic needles or local exposure of the tumor using a plastic box or tube. Results: To test if gNO at 150-50,000ppm can decrease cancer cell viability, cells were exposed (I) directly to NO in a 96 well plate or (II) in an acrylic glass box. Cell viability was tested 24hrs later by XTT. According to our findings, less than 3% of 4T1 cells remain viable when exposed to 10,000ppm NO for 3 minutes or 50,000ppm NO for 1 minute in a 96-well plate. ~1% of CT26 cells remain viable after exposure to 50,000ppm NO for 10 seconds in a 96 well plate; while less than 10% remain viable after 1 minute of exposure of 50,000ppm NO in a box. To test if gNO at 10,000-50,000ppm can destroy mouse colon cancer tumors in-vivo, tumors were exposed to gNO locally by hypodermic needles or a plastic cover. Air treated tumor bearing mice served as the control group. A complete tumor destruction was observed when the skin was removed from the tumor and the entire tumor was exposed to 10,000ppm gNO for 10 minutes. Conclusion: In the current work, gNO at high concentration showed a substantial cytotoxic effect on cancer cells in-vitro and in-vivo. The proposed project represents development of a novel treatment for cancer. Our innovative gNO based treatment may serve to treat solid tumors locally or be used as an adjunctive therapy for surgery and can be synergized with common anticancer therapies, such as chemotherapy and radiotherapy, to further enhance the effect. Citation Format: Hila Confino, Steve Lisi, Rinat Kalaora, Matan Goldshtein, Amir Avniel. Gaseous nitric oxide at high concentration is a powerful anti-tumor agent both in-vitro and in-vivo [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 6371.
Online Semiparametric Identification of Lithium-Ion Batteries Using the Wavelet-Based Partially Linear Battery Model (2013)

Battery model identification is very important for reliable battery management as well as for battery system design process. The common problem in identifying battery models is how to determine the most appropriate mathematical model structure and parameterized coefficients based on the measured terminal voltage and current. This paper proposes a novel semiparametric approach using the wavelet-based partially linear battery model (PLBM) and a recursive penalized wavelet estimator for online battery model identification. Three main contributions are presented. First, the semiparametric PLBM is proposed to simulate the battery dynamics. Compared with conventional electrical models of a battery, the proposed PLBM is equipped with a semiparametric partially linear structure, which includes a parametric part (involving the linear equivalent circuit parameters) and a nonparametric part [involving the open-circuit voltage (OCV)]. Thus, even with little prior knowledge about the OCV, the PLBM can be identified using a semiparametric identification framework. Second, we model the nonparametric part of the PLBM using the truncated wavelet multiresolution analysis (MRA) expansion, which leads to a parsimonious model structure that is highly desirable for model identification; using this model, the PLBM could be represented in a linear-in-parameter manner. Finally, to exploit the sparsity of the wavelet MRA representation and allow for online implementation, a penalized wavelet estimator that uses a modified online cyclic coordinate descent algorithm is proposed to identify the PLBM in a recursive fashion. The simulation and experimental results demonstrate that the proposed PLBM with the corresponding identification algorithm can accurately simulate the dynamic behavior of a lithium-ion battery in the Federal Urban Driving Schedule tests.
Biomechanical Analysis of Knee Laxity With Isolated Anteromedial or Posterolateral Bundle–Deficient Anterior Cruciate Ligament (2014)

If there is a clinically identifiable increase in laxity, then--in addition to the isolated tear of the AM or PL bundle--there must also be a tear of the other bundle of the ACL, or at least a partial tear.
Kinetic Study of the Acid Hydrolysis of Various Oligofructose Samples (2002)

The kinetic of acid hydrolysis of five commercially available oligofructose samples used as food ingredients has been investigated as a function of the dry matter concentration, reaction pH, and temperature. The initial fructose release rate is found to be roughly proportional to the inverse of the average polymerization degree in number. A pseudo first order kinetic is found with respect to the fructosyl chain end concentration and to the proton concentration. Arrhenius plot is found to reasonably fit the data in a relatively wide temperature range (7-130 degrees C). The results allow the estimation of the fructose release rate in many foodstuff processing conditions.
A novel extracellular esterase from <i>Bacillus subtilis</i> and its conversion to a monoacylglycerol hydrolase (2000)

A novel gene lipB, which encodes an extracellular lipolytic enzyme, was identified in the Bacillus subtilis genomic DNA sequence. We have cloned and overexpressed lipB in B. subtilis and Escherichia coli and have also purified the enzyme from a B. subtilis culture supernatant to electrophoretic homogeneity. Four different lipase assays were used to determine its catalytic activity: pH-stat, spectrophotometry, fluorimetry and the monomolecular film technique. LipB preferentially hydrolysed triacylglycerol-esters and p-nitrophenyl-esters of fatty acids with short chain lengths of </= 10 carbon atoms. Triolein, which is a typical substrate for true lipases, was not hydrolysed at all. These results led us to classify LipB as an esterase rather than a lipase. The catalytic triad of LipB consists of residues Ser78, Asp134, and His157 as demonstrated by amino-acid sequence alignments and site-directed mutagenesis. The nucleophile Ser78 is located in a lipase-specific consensus sequence, which is Ala-X-Ser-X-Gly for most Bacillus lipases. All other bacterial lipases contain a glycine residue instead of the alanine at position-2 with respect to the catalytic serine. We have investigated the role of this alanine residue by constructing LipB variant A76G, thereby restoring the lipase-specific consensus motif. When compared with LipB this variant showed a markedly reduced thermostability but an increased stability at pH 5-7. Determination of the specific activities of wild-type LipB and variant A76G using a monomolecular film of the substrate monoolein revealed an interesting result: the A76G substitution had converted the esterase LipB into a monoacylglycerol hydrolase.
CT diagnosis of abdominal trauma and its clinical significance (2014)

Objective To investigate the CT diagnosis of abdominal trauma and its clinical significance.Methods From February 2011 to February 2013,120 patients with abdominal trauma were selected as study objects.All of the patients were given CT diagnosis,and the CT diagnosis results and surgical treatment results were compared.Results There were 55 cases(45.83％) of splenic injury,17 cases(14.17％) of liver injury,25 cases(20.83％) of gastrointestinal tract and mesenteric injuries,4 cases(3.33％) of bladder injury,4 cases(3.33％) of bile duct injury,6 patients(5.00％) of pancreatic injury,9 cases(7.50％) of renal contusion under CT diagnosis.The consistent rate was 95.33％ of CT diagnosis and surgical treatment results.In addition,among the 13 patients treated with conservative treatment,2 patients died,and the mortality rate was 15.38％.Conclusions CT in the diagnosis of abdominal trauma has high rate of accuracy,can be used as an important screening tool,and provides important basis for clinical treatment.

Key words: 
Abdominal trauma;  CT diagnosis ;  Surgery ;  Clinical significance
Impact of Regular or Extended Hemodialysis and Hemodialfiltration on Plasma Oxalate Concentrations in Patients With End-Stage Renal Disease (2017)

In contrast to earlier observations, our data did not support a benefit of HDF over HD for P<sub>Ox</sub> reduction. With new technologies evolving, our results emphasized the need to carefully reevaluate and update traditional therapeutic regimens for optimized uremic toxin removal, including those used for oxalate.
Infrared body temperature measurement of mice as an early predictor of death in experimental fungal infections (2003)

Temperatures of mice were measured using an infrared high performance non-contact thermometer, after the device had been calibrated using implantable microchips containing temperature transponders. Mice were infected with three species of Candida (isolates) and the resultant disseminated infections monitored. Mouse temperatures could be reliably measured using the infrared device and this measurement caused little distress to the mice. We were further able to demonstrate that mice rarely recovered if their body temperature dropped below 33.3 degrees C (sensitivity 68%, specificity 97%). Adoption of a 33.3 degrees C endpoint in fungal sepsis experiments measured by infrared non-contact thermometer would significantly reduce the suffering in the terminal stages of this type of infection model.
Role of Semantics in Question Answering (2010)

This chapter shows that various semantic data play important roles in the QA process. For this purpose, it first describes QA and the basic structure of a QA-automated system. The chapter introduces Lymba’s expressive knowledge representation of text, a layered representation with multiple levels of semantic information identified in text, and a representation that yields well for automated processing of natural language. Then, it describes in detail the architecture of PowerAnswer, Lymba’s state-of-the-art QA system, best performing system at the QA track of the TREC between 2000 and 2008. Semantic information is used in all PowerAnswer’s modules for accurate QA processing. The chapter summarizes the mapping of semantic functionalities and QA components. The following semantic modules are presented in detail: Word sense disambiguation, eXtended WordNet Knowledge, EventNet, Lexical chains, Semantic relations, Contexts, Events, and the natural language reasoning engine. Controlled Vocabulary Terms meta data; question answering (information retrieval); search engines