gebhart/patrepeval huggingface dataset:
Accurate 3D pose estimation from a single depth image (2011)

This paper presents a novel system to estimate body pose configuration from a single depth map. It combines both pose detection and pose refinement. The input depth map is matched with a set of pre-captured motion exemplars to generate a body configuration estimation, as well as semantic labeling of the input point cloud. The initial estimation is then refined by directly fitting the body configuration with the observation (e.g., the input depth). In addition to the new system architecture, our other contributions include modifying a point cloud smoothing technique to deal with very noisy input depth maps, a point cloud alignment and pose search algorithm that is view-independent and efficient. Experiments on a public dataset show that our approach achieves significantly higher accuracy than previous state-of-art methods.
Synthesis of Filibuvir. Part I. Diastereoselective Preparation of a β-Hydroxy Alkynyl Oxazolidinone and Conversion to a 6,6-Disubstituted 2<i>H</i>-Pyranone (2013)

This is the first in a series of three papers describing the identification and development of a commercial synthesis of filibuvir (1). This contribution describes development of an Evans aldol reaction to control the tertiary alcohol stereocenter, a challenging variant of that strategy in that both reacting partners were nonstandard (acetate enolate and ketone electrophile). A sequence consisting of Sonogashira coupling, acylation and hydrogenation delivered acetate 24, and Dieckmann cyclization provided β-keto lactone 2.
Stereochemical evidence for pseudorotation in the reaction of a phosphoric monoester (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical evidence for pseudorotation in the reaction of a phosphoric monoesterStephen L. Buchwald, Diana H. Pliura, and Jeremy R. KnowlesCite this: J. Am. Chem. Soc. 1984, 106, 17, 4916–4922Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/ja00329a048https://doi.org/10.1021/ja00329a048research-articleACS PublicationsRequest reuse permissionsArticle Views624Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Research on Human-Computer Interaction of English Teaching at Local Area Network (2010)

In view of China's one-child policy, as a learner, each only child in the family has his or her personality. This article built a learner's personality-centered model of Human-Computer Interaction System, then analyzed its key techniques and methods, and established the theory on this basis through analyzing the features of this system and making research on English Teaching by such system at Local Area Network. The system software can also be applied to Human-Computer Interaction of following situations like teaching of other curriculums, industry automatic control, unmaned control and so on if slightly changed.
Design, calibration and characterization of a low-cost spatial Fourier transform LWIR hyperspectral imaging camera with spatial and temporal scanning modes (2018)

Hyperspectral imaging in the longwave infrared region (LWIR) offers a unique day and night sensor capability currently not available in other spectral ranges. Current proliferation of the technology is however often limited by the size, weight, power and cost (SWaP-C) requirements of the available instruments. This paper presents a low-cost spatial Fourier Transform LWIR hyperspectral imaging camera, based on a corner cube Michelson interferometer and an uncooled microbolometer. In addition to conventional spatial pushbroom scanning, e.g. provided by a moving platform, the current interferometric setup can use temporal scanning of a stationary field-of-view due to a spatially offset stepper motor controlled corner cube retroreflector. The design and calibration and a characterization of the instrument are presented. Applications and future modifications are also discussed.
Active, uncalibrated visual servoing (2002)

Proposes a method for visual control of a robotic system which does not require the formulation of an explicit calibration between image space and the world coordinate system. Calibration is known to be a difficult and error prone process. By extracting control information directly from the image, the authors free their technique from the errors normally associated with a fixed calibration. The authors demonstrate this by performing a peg-in-hole alignment using an uncalibrated camera to control the positioning of the peg. The algorithm utilizes feedback from a simple geometric effect, rotational invariance, to control the positioning servo loop. The method uses an approximation to the image Jacobian to provide smooth, near-continuous control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In-Phase and Anti-Phase Power Dividers for UWB Differentially Fed Antenna Arrays (2010)

This letter presents two novel power dividers operating in the FCC frequency range from 3.1 to 10.6 GHz. The two outputs of each power divider are coplanar striplines, while the input is a microstrip line. Hence, the power dividers act as baluns and are suited for differentially fed antennas. The in-phase version shows a return loss of better than 15 dB from 1 to 12.3 GHz, whereas for the anti-phase version the return loss is better than 10 dB from 1 to 12.3 GHz. Besides the characterization of the dividers, a linear antenna array fed by one of the dividers is shown, and measurement results in the time domain and frequency domain are presented. The mean gain of the realized four-element array is 9.7 dBi.
Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of the <i>Clostridium botulinum</i> Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility (2011)

Neurotoxins synthesized by Clostridium botulinum bacteria (BoNT), the etiological agent of human botulism, are extremely toxic proteins making them high-risk agents for bioterrorism. Small molecule inhibitor development has been focused on the light chain zinc-dependent metalloprotease domain of the neurotoxin, an effort that has been hampered by its relatively flexible active site. Developed in concert with structure--activity relationship studies, the X-ray crystal structures of the complex of BoNT serotype A light chain (BoNT/A LC) with three different micromolar-potency hydroxamate-based inhibitors are reported here. Comparison with an unliganded BoNT/A LC structure reveals significant changes in the active site as a result of binding by the unique inhibitor scaffolds. The 60/70 loop at the opening of the active site pocket undergoes the largest conformational change, presumably through an induced-fit mechanism, resulting in the most compact catalytic pocket observed in all known BoNT/A LC structures.
Global Anthropogenic Methane and Nitrous Oxide Emissions (2006)

Methane and Nitrous Oxide emissions contribute significantly to greenhouse gas emissions globally, with an estimated total of 1,618 and 950 million metric tons of carbon equivalent in 2000, respectively. The estimates of these gases are highly dependent on country specific activity data and emission factors. Most countries are presently or are in the process of developing greenhouse gas inventories and projections. Developed countries are using more in-depth, detailed methodologies, activity data, and emissions factors and are passing on this knowledge to other countries through bilateral and multilateral processes. In order to take advantage of this newly available information, we have incorporated the detailed country prepared inventories and projections into an overall global estimation framework. The source and country level estimation methodology presented in this study allows for more accurate anthropogenic emission level estimates at a global level. The results show a slow growth in the recent historical period with quicker growth to 2020, under a without measures scenario.
Human serum albumin and Tween 80 as stabilizers of allergen solutions (1978)

Abstract Intradermal skin testing may often give inaccurate results because of poor stability of allergens and loss of protein by adsorption to the walls of containers and syringes during the process of making the extreme dilutions required with potent extracts. To test the ability of stabilizers to prevent such losses of allergenic activity, three diluents for allergens were compared: standard phosphate-buffered saline (PBS), pH 7.4, containing 0.4% phenol and the same buffer containing either 0.03% human serum albumin (HSA) or 0.005% Tween 80. Tenfold dilution series of ragweed, grass, Altemaria , and dust allergens were tested by the intradermal threshold dilution technique in the same group of patients five times over six months, comparing stored dilutions with dilutions freshly made from the same batches of lyophilized extracts. Results with Tween 80 and HSA buffers were identical and highly reproducible; however, each new set of dilutions in standard buffers frequently showed within 24 to 48 hr after preparation a lower skin test potency which varied unpredictably between ten and one thousandfold. Furthermore, upon prolonged storage at 4 °C, dilutions in standard buffer lost further activity. Storage of radiolabeled antigen E (AgE) in ordinary glass tubes for 24 hr showed adsorption of about 5% of the labeled protein to glass in the absence of stabilizers but only 0.5% in the presence of stabilizers. We conclude that stabilizing agents should be added to diluting fluids in preparing allergens for skin testing or immunotherapy.
Optimal $C$-Type Passive Filter Based on Minimization of the Voltage Harmonic Distortion for Nonlinear Loads (2011)

In its broadest sense, passive filters have been a very potent technique for power system harmonic suppression because of their possible different frequency response characteristics that can achieve a certain required harmonic filtering target, also due to their simplicity and economical cost. This paper presents an application of FORTRAN feasible sequential quadratic programming to find the optimal sizing of parameters of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</i> -type passive filters for minimizing the total voltage harmonic distortion of nonlinear loads, where maintaining a given power factor at a specified range is desired. The optimal design of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</i> -type passive filter as an alternative to the conventional passive filtering techniques is introduced, and a detailed comparison of the results between an uncompensated system and a <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</i> -type filter are discussed by means of different numerical examples, considering source and load nonlinearities, while taking into account compliance with the IEEE standards 519-1992 and 18-2002.
A Mechanism for the Oxidation of Glutathione to Glutathione Disulfide with Organotellurium(IV) and Organoselenium(IV) Compounds. A Stepwise Process with Implications for Photodynamic Therapy and Other Oxidative Chemotherapy (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Mechanism for the Oxidation of Glutathione to Glutathione Disulfide with Organotellurium(IV) and Organoselenium(IV) Compounds. A Stepwise Process with Implications for Photodynamic Therapy and Other Oxidative ChemotherapyMichael R. Detty, Alan E. Friedman, and Alan R. OseroffCite this: J. Org. Chem. 1994, 59, 26, 8245–8250Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jo00105a049https://doi.org/10.1021/jo00105a049research-articleACS PublicationsRequest reuse permissionsArticle Views511Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cooperative Multipoint Recognition of Sialic Acid by Benzoboroxole-Based Receptors Bearing Cationic Hydrogen-Bond Donors (2020)

Sialic acid recognition remains an interesting and challenging target in molecular receptor design. Herein, we report a series of benzoboroxole-based receptors in which cationic hydrogen-bond donors have been introduced and shown to promote multipoint sialic acid recognition. One striking feature revealed by these receptors is that the carboxylate sialic acid residue is the primary binding determinant for recognition by benzoboroxole, in which the presence of charge-reinforced hydrogen bonds results in enhanced selectivity for sialic acid over other carbohydrates and a 4.5-fold increase in affinity. These findings open up wide possibilities for benzoboroxole-based receptors use in life science research, biotechnology, and diagnostics.
A Study on the Implementation and Evaluation of a Semantic Search System (2008)

In this paper, we present an application called Semantic Search which is built on different supporting technologies and is designed to improve traditional web searching. The Semantic Search is becoming crucial challenges on semantic web. The assessment and the implementation of the research on Semantic Search is not full-fledged whereas its research is highly interested. Also there exists only little research that offers a commercial use Semantic Search System that should be taken into the account in measuring the effectiveness of a Semantic Search System. This paper proposes an implementation and evaluation for the Semantic Search System. Firstly, we built Semantic Search System which includes a case of development and it's procedure. Secondly, We presented the measurement of our Semantic Search System's effectiveness. Finally, the evaluation offers useful implications to the researchers and practitioners to improve the research level to the commercial use.
Current-Aware Flash Scheduling for Current Capping in Solid State Disks (2018)

Solid state disks (SSDs) employ internal parallelism to boost their input/output (I/O) performance, but a high degree of flash parallelism inevitably consumes a high level of current. To budget power or support multiple power sources, system software may force an SSD into a new power mode that has a specific current supply limit. This paper introduces a firmware approach to optimize SSD internal parallelism subject to a current supply limit. The proposed method involves two steps. First, we constructed current models of flash operations on the basis of real-world measurement results. Second, we designed a firmware scheduler to determine the actual starting time of each flash operation. The proposed scheduler accounted for flash aging, process variation, and internal resource contention, and it avoided any current cap violation by checking a few time points instead of every unit of time. Our experimental results indicated that the proposed approach outperformed existing methods with respect to I/O response time and throughput under realistic workloads.
Variation, innovation and dynamic quality (1998)

This paper discusses the concepts of static and dynamic quality enunciated by Robert Pirsig in relation to concepts of variation and statistical control enunciated by W. Edwards Deming. The relationship between static and dynamic is seen to reflect a fundamental truth present in many systems, and is posited to lead to approaches to foster innovation and dynamic change. Three dimensions for addressing dynamic change concern operational processes, organizations and the environment. Along all three dimensions, the challenge for organizations is how to foster, recognize and manage the variation necessary for dynamic change. Approaches are discussed for doing this and conclusions are presented.
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence (2019)

Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here we demonstrate that the known synthetic lethal interaction between poly(ADP-ribose) polymerase 1 inhibitors (PARPi) and DNA repair triggers p53-independent ovarian cancer cell senescence defined by senescence-associated phenotypic hallmarks including DNA-SCARS, inflammatory secretome, Bcl-XL-mediated apoptosis resistance, and proliferation restriction via Chk2 and p21 (CDKN1A). The concept of senescence as irreversible remains controversial and here we show that PARPi-senescent cells re-initiate proliferation upon drug withdrawal, potentially explaining the requirement for sustained PARPi therapy in the clinic. Importantly, PARPi-induced senescence renders ovarian and breast cancer cells transiently susceptible to second-phase synthetic lethal approaches targeting the senescence state using senolytic drugs. The combination of PARPi and a senolytic is effective in preclinical models of ovarian and breast cancer suggesting that coupling these synthetic lethalities provides a rational approach to their clinical use and may together be more effective in limiting resistance.
Yule-Nielsen effect in halftone prints: graphical analysis method and improvement of the Yule-Nielsen transform (2014)

The well-known Yule-Nielsen modified spectral Neugebauer model is one of the most accurate predictive models for the spectral reflectance of printed halftone colors which expresses the spectral reflectance of halftones raised to the power 1/<i>n</i> as a linear combination of the spectral reflectance of the fulltone colors (Neugebauer primaries) also raised to the power 1/<i>n</i>, where <i>n</i> is a tunable real number. The power 1/<i>n</i> transform, characteristic of the Yule-Nielsen transform, empirically models the nonlinear relationship between the spectral reflectances of halftones and fulltones due to the internal propagation of light by scattering into the printing support, a phenomenon known as “optical dot gain” or “Yule- Nielsen effect”. In this paper, we propose a graphical method permitting to observe this non-linear relationship in the case of single-ink halftones and to experimentally check the capacity of the Yule-Nielsen model to predict it accurately. In the case where the Yule-Nielsen transform is not well adapted to the considered type of prints, we propose alternative transforms in order to improve the prediction accuracy.
The molecular basis of IL-21–mediated proliferation (2007)

Interleukin-21 (IL-21) is a type I cytokine that modulates functions of T, B, natural killer (NK), and myeloid cells. The IL-21 receptor (IL-21R) is closely related to the IL-2 receptor beta chain and is capable of transducing signals through its dimerization with the common cytokine receptor gamma chain (gamma(c)), the protein whose expression is defective in humans with X-linked severe combined immunodeficiency. To clarify the molecular basis of IL-21 actions, we investigated the role of tyrosine residues in the IL-21R cytoplasmic domain. Simultaneous mutation of all 6 tyrosines greatly diminished IL-21-mediated proliferation, whereas retention of tyrosine 510 (Y510) allowed full proliferation. Y510 efficiently mediated IL-21-induced phosphorylation of Stat1 and Stat3, but not of Stat5, and CD8(+) T cells from Stat1/Stat3 double knock-out mice exhibited decreased proliferation in response to IL-21 + IL-15. In addition, IL-21 weakly induced phosphorylation of Shc and Akt, and consistent with this, specific inhibitors of the MAPK and PI3K pathways inhibited IL-21-mediated proliferation. Collectively, these data indicate the involvement of the Jak-STAT, MAPK, and PI3K pathways in IL-21 signaling.
Accounting of Financial Risk Hedging Tools (2015)

The article is devoted to improvement of representing of the operations with derivative financial instruments on the bookkeeping accounts. The existing methodological principles of accounting of operations with futures and option contracts by share market players are analyzed, and the proposals worked out as to their enhancement. Described in detail is procedure for accounting of operations with the futures for purchase and sales of assets, operations with various option types, operations with the derivative financial instruments (derivatives) for securities. It is proposed to represent the purchase of options on off-balance account 06 'Received guarantees and collaterals', and the collateral of the stock exchange derivatives execution â€“ using the account 379 'Settlements of operations with derivatives'. It is shown that it is not reasonable to represent the variation margin within other operational incomes and expenses because the financial incomes and expenses are meant. The methodological approach was substantiated to the accounting of the operations with derivatives for securities in accordance with the requirements of IFRS 32 'Financial Instruments: Presentation'.