gebhart/patrepeval huggingface dataset:
24-Way Radial Power Combiner/Divider for 31 to 36 GHz (2008)

The figure shows a prototype radial power-combining waveguide structure, capable of operation at frequencies from 31 to 36 GHz, that features an unusually large number (N = 24) of combining (input) ports. The combination of wide-band operation and large N is achieved by incorporating several enhancements over a basic radial power-combiner design. In addition, the structure can be operated as a power divider by reversing the roles of the input and output ports. In this structure, full-height waveguides at the combining ports are matched in impedance to reduced-height radial waveguides inside the combiner base. This match is effected by impedance-transforming stepped waveguide sections. This matching scheme is essential to achievement of large N because N is limited by the height of the waveguides in the base. Power is coupled from the 24 reduced- height radial waveguides into the TE01 mode of a circular waveguide in the base with the help of a matching post at the bottom of the base. ( TE signifies transverse electric, the first subscript is the azimuthal mode number, and the second subscript is the radial mode number.) More specifically, the matching post matches the reflections from the walls of the 24 reduced-height waveguides and enables the base design to exceed the bandwidth requirement. After propagating along the circular waveguide, the combined power is coupled, via a mode transducer, to a rectangular waveguide output port. The mode transducer is divided into three sections, each sized and shaped as part of an overall design to satisfy the mode-conversion and output-coupling requirements while enabling the circular waveguide to be wide enough for combining the 24 inputs over the frequency range of 31 to 36 GHz. During the design process, it was found that two different rectangular waveguide outputs could be accommodated through modification of only the first section of the mode converter, thereby enabling operation in multiple frequency ranges.
Robust 3-D Airway Tree Segmentation for Image-Guided Peripheral Bronchoscopy (2010)

A vital task in the planning of peripheral bronchoscopy is the segmentation of the airway tree from a 3-D multidetector computed tomography chest scan. Unfortunately, existing methods typically do not sufficiently extract the necessary peripheral airways needed to plan a procedure. We present a robust method that draws upon both local and global information. The method begins with a conservative segmentation of the major airways. Follow-on stages then exhaustively search for additional candidate airway locations. Finally, a graph-based optimization method counterbalances both the benefit and cost of retaining candidate airway locations for the final segmentation. Results demonstrate that the proposed method typically extracts 2-3 more generations of airways than several other methods, and that the extracted airway trees enable image-guided bronchoscopy deeper into the human lung periphery than past studies.
Development of an intelligent air brake warning system for commercial vehicles (1996)

Air-brake-equipped vehicles are prone to serious problems peculiar to their design that can result in loss of braking effectiveness with little warning to the driver. Research is presented that leads to the design of an intelligent air brake warning device (IBWD) that, through various sensors and an analytical algorithm, will provide drivers and authorities with critical information about brake condition. The IBWD performs an inferential, on-board, real-time assessment of vehicle brake performance through measurement of only a few parameters, namely deceleration, application air pressure, vehicle weight, speed, and response pressures at various axles. It will not involve wheel-to-wheel measurements of brake adjustment or temperature, though it will be sensitive to loss of performance from excesses in either.
Full scale testing of various heavy truck configurations was performed in two sessions. Data analysis from the first session assessed the significance of the various measurable parameters and provided a foundation for a software mock-up of an IBWD. The second test session demonstrated the feasibility of the IBWD software and gathered data under more realistic conditions. Data were then extensively analyzed for traits that portend loss of brake efficiency. Multiple regression model optimization techniques were used to develop several robust models that accurately describe vehicle braking propensity. Models of three response variables were found to hold promise for the IBWD algorithm: deceleration, air transmission lag time, and brake response pressure decay time.
A framework for an IBWD algorithm is presented. A two-mode system is proposed: vehicles will first be trained with brakes that are cool and properly maintained; once trained, brake performance data acquired while the vehicle is in normal operation will be compared with the model. Deviations from the model will be analyzed; if warranted, a warning of impending brake degradation will be issued.
A novel immunization approach for dengue infection based on conserved T cell epitopes formulated in calcium phosphate nanoparticles (2017)

Dengue virus (DV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Most DV vaccine approaches are focused on generating antibody mediated responses; one such DV vaccine is approved for use in humans but its efficacy is limited. While it is clear that T cell responses play important role in DV infection and subsequent disease manifestations, fewer studies are aimed at developing vaccines that induce robust T cells responses. Potent T cell based vaccines require 2 critical components: the identification of specific T cell stimulating MHC associated peptides, and an optimized vaccine delivery vehicle capable of simultaneously delivering the antigens and any required adjuvants. We have previously identified and characterized DV specific HLA-A2 and -A24 binding DV serotypes conserved epitopes, and the feasibility of an epitope based vaccine for DV infection. In this study, we build on those previous studies and describe an investigational DV vaccine using T cell epitopes incorporated into a calcium phosphate nanoparticle (CaPNP) delivery system. This study presents a comprehensive analysis of functional immunogenicity of DV CaPNP/multipeptide formulations in vitro and in vivo and demonstrates the CaPNP/multipeptide vaccine is capable of inducing T cell responses against all 4 serotypes of DV. This synthetic vaccine is also cost effective, straightforward to manufacture, and stable at room temperature in a lyophilized form. This formulation may serve as an effective candidate DV vaccine that protects against all 4 serotypes as either a prophylactic or therapeutic vaccine.
Three-dimensional motion correction using speckle and phase for in vivo computed optical interferometric tomography (2014)

Over the years, many computed optical interferometric techniques have been developed to perform high-resolution volumetric tomography. By utilizing the phase and amplitude information provided with interferometric detection, post-acquisition corrections for defocus and optical aberrations can be performed. The introduction of the phase, though, can dramatically increase the sensitivity to motion (most prominently along the optical axis). In this paper, we present two algorithms which, together, can correct for motion in all three dimensions with enough accuracy for defocus and aberration correction in computed optical interferometric tomography. The first algorithm utilizes phase differences within the acquired data to correct for motion along the optical axis. The second algorithm utilizes the addition of a speckle tracking system using temporally- and spatially-coherent illumination to measure motion orthogonal to the optical axis. The use of coherent illumination allows for high-contrast speckle patterns even when imaging apparently uniform samples or when highly aberrated beams cannot be avoided.
New Stains for Blood and Bone Marrow Cells (1990)

Traditionally, blood and bone marrow cells have been identified based on their characteristic shapes and colors when stained with one of several panoptic stains including Wright's or Giemsa's. As questions arose regarding the origin of normal and leukemic cells, cytochemical stains were developed. These stains help identify cells on the basis of a distinctive metabolite or enzyme. As part of an ongoing tradition in which textile dyes are used for biological staining, several new stains have been applied to hematologic staining. These include C.I. basic blue 41, basic blue 141, basic blue 93, and an asymmetrical polymethine dye. As additional cell-selective stains are developed, we can anticipate further improvements in our ability to identify normal and malignant hematopoietic cells.
High-Performance Flexible Solid-State Supercapacitor with an Extended Nanoregime Interface through in Situ Polymer Electrolyte Generation (2015)

Here, we report an efficient strategy by which a significantly enhanced electrode-electrolyte interface in an electrode for supercapacitor application could be accomplished by allowing in situ polymer gel electrolyte generation inside the nanopores of the electrodes. This unique and highly efficient strategy could be conceived by judiciously maintaining ultraviolet-triggered polymerization of a monomer mixture in the presence of a high-surface-area porous carbon. The method is very simple and scalable, and a prototype, flexible solid-state supercapacitor could even be demonstrated in an encapsulation-free condition by using the commercial-grade electrodes (thickness = 150 μm, area = 12 cm(2), and mass loading = 7.3 mg/cm(2)). This prototype device shows a capacitance of 130 F/g at a substantially reduced internal resistance of 0.5 Ω and a high capacitance retention of 84% after 32000 cycles. The present system is found to be clearly outperforming a similar system derived by using the conventional polymer electrolyte (PVA-H3PO4 as the electrolyte), which could display a capacitance of only 95 F/g, and this value falls to nearly 50% in just 5000 cycles. The superior performance in the present case is credited primarily to the excellent interface formation of the in situ generated polymer electrolyte inside the nanopores of the electrode. Further, the interpenetrated nature of the polymer also helps the device to show a low electron spin resonance and power rate and, most importantly, excellent shelf-life in the unsealed flexible conditions. Because the nature of the electrode-electrolyte interface is the major performance-determining factor in the case of many electrochemical energy storage/conversion systems, along with the supercapacitors, the developed process can also find applications in preparing electrodes for the devices such as lithium-ion batteries, metal-air batteries, polymer electrolyte membrane fuel cells, etc.
Masking Technique for Ion-Beam Sputter Etching (1986)

Improved process for fabrication of integrated circuits developed. Technique utilizes simultaneous ion-beam sputter etching and carbon sputter deposition in conjunction with carbon sputter mask or organic mask decomposed to produce carbon-rich sputter-mask surface. Sputter etching process replenishes sputter mask with carbon to prevent premature mask loss.
Evaluation of methyl iodide as a soil fumigant in container and small field plot studies (1998)

Methyl iodide was evaluated as a soil fumigant as a potential replacement for the widely used soil fumigant methyl bromide. In container trials, methyl iodide was significantly more effective than methyl bromide against the plant parasitic nematodes Meloidogyne incognita, Heterodera schachtii and Tylenchulus semipenetrans and the plant pathogenic fungus Rhizoctonia solani. In small field plots, soil populations of root-knot nematodes were no longer detected after methyl iodide fumigation at an application rate of 112 kg ha-1. However, after growing a susceptible lima bean host for two months, substantial root-knot galling occurred, while Rhizobium nodulation was absent. At 168 kg ha-1 of methyl iodide, root-knot galling was reduced to less than 1%, and no Pythium propagules were recovered on selective detection media. These efficacy data support the conclusion that methyl iodide is a likely candidate for replacing methyl bromide as a soil fumigant. © 1998 SCI.
Discrete Event Command and Control for Formation Flying of Distributed Small Spacecraft Systems (1999)

Abstract. A distributed, multi-vehicle concept for future space missions has been conceived as a solution to the problem of advancing space-based operations within budgetary constraints. Broadly named formation flying, this approach to designing distributed systems across multiple, spatially disbursed platforms is enabled by collectively coordinating a fleet of autonomous spacecraft to function as a unified system. Formation flying offers potential advantages of improved robustness, capability, and cost relative to complicated, single platform systems by using multiple, often small, spacecraft to perform complex multi-sensor tasks. A necessary element in the realization of formation flying systems is the development of methods and technologies that facilitate the transition from treating a distributed spacecraft system as individual elements, to viewing a formation as a coordinated system unified by common objectives. This paper describes the results of research performed to identify fundamental issues that affect the development of command and control (C2) methods applicable to coordinating distributed small spacecraft systems. A discrete event method of distributed command and control is described that is particularly well suited to small spacecraft formation flying. Utilized in many complex terrestrial systems, discrete event systems (DES) concepts facilitate coordination of distributed systems at multiple levels of resolution in an efficient manner. DES also provide a means to integrate intelligent planning and processing operations while interfacing with more traditional subsystem controllers. The basic principals and applicability of DES are described within the context of formation flying and example distributed spacecraft C2 operations are defined.
Lubricant-Derived Ash Properties and Their Effects on Diesel Particulate Filter Pressure Drop Performance (2009)

Diesel particulate filters (DPF) have seen widespread use in on- and off-road applications as an effective means for meeting increasingly stringent particle emissions regulations. Over time, incombustible material or ash, primarily derived from metallic additives in the engine lubricant, accumulates in the DPF. Ash accumulation leads to increased flow restriction and an associated increase in pressure drop across the particulate filter, negatively impacting engine performance and fuel economy, and eventually requiring periodic filter service or replacement. While the adverse effects of ash accumulation on DPF performance are well known, the underlying mechanisms controlling these effects are not. The results of this work show ash accumulation and distribution in the DPF as a dynamic process with each stage of ash accumulation altering the filter’s pressure drop response. Through a combined approach employing targeted experiments and comparison with the existing knowledge base, this work further demonstrates the significant effect ash deposits have on DPF pressure drop sensitivity to soot accumulation. Ash deposits reduce the available filtration area, resulting in locally elevated soot loads and higher exhaust gas velocities through the filter, altering the conditions under which the soot is deposited and ultimately control the filter’s pressure drop characteristics. In this study, a novel accelerated ash loading system was employed to generate the ash and load the DPFs under carefully-controlled exhaust conditions. The ash loading system was coupled to the exhaust of a Cummins ISB diesel engine, allowing for accelerated ash loading and DPF performance evaluation with realistic exhaust conditions. Following DPF performance evaluation, the filters were subjected to a detailed post-mortem analysis in which key ash properties were measured and quantified. The experimental results, coupled with the ash property measurements, provide additional insight into the underlying physical mechanisms controlling ash properties, ash/soot interactions, and their effects on DPF performance.
A Repertoire of Novel Antibacterial Diastereomeric Peptides with Selective Cytolytic Activity (1997)

The increase in infectious diseases and bacterial resistance to antibiotics has resulted in intensive studies focusing on the use of linear, alpha-helical, cytolytic peptides from insects and mammals as potential drugs for new target sites in bacteria. Recent studies with diastereomers of the highly potent cytolytic peptides, pardaxin and melittin, indicate that alpha-helical structure is required for mammalian cells lysis but is not necessary for antibacterial activity. Thus, hydrophobicity and net positive charge of the polypeptide might confer selective antibacterial lytic activity. To test this hypothesis, a series of diastereomeric model peptides (12 amino acids long) composed of varying ratios of leucine and lysine were synthesized, and their structure and biological function were investigated. Peptide length and the position of D-amino acids were such that short peptides with stretches of only 1-3 consecutive L-amino acids that cannot form an alpha-helical structure were constructed. Circular dichroism spectroscopy showed that the peptides do not retain any detectable secondary structure in a hydrophobic environment. This enabled examination of the sole effect of hydrophobicity and positive charge on activity. The data reveal that modulating hydrophobicity and positive charge is sufficient to confer antibacterial activity and cell selectivity. A highly hydrophobic diastereomer that permeated both zwitterionic and negatively charged phospholipid vesicles, lysed eukaryotic and prokaryotic cells. In contrast, a highly positively charged diastereomer that only permeated slightly negatively charged phospholipid vesicles had low antibacterial activity and could not lyse eukaryotic cells. In the boundary between high hydrophobicity and high positive charge, the diastereomers acquired selective and potent antibacterial activity. Furthermore, they were completely resistant to human serum inactivation, which dramatically reduces the activity of native antibacterial peptides. In addition, a strong synergistic effect was observed at nonlethal concentrations of the peptides with the antibiotic tetracycline on resistant bacteria. The results are discussed in terms of proposed mechanisms of antibacterial activity, as well as a new strategy for the design of a repertoire of short, simple, and easily manipulated antibacterial peptides as potential drugs in the treatment of infectious diseases.
Rewriting flash memories by message passing (2015)

This paper constructs WOM codes that combine rewriting and error correction for mitigating the reliability and the endurance problems in flash memory.We consider a rewriting model that is of practical interest to flash applications where only the second write uses WOM codes. Our WOM code construction is based on binary erasure quantization with LDGM codes, where the rewriting uses message passing and has potential to share the efficient hardware implementations with LDPC codes in practice. We show that the coding scheme achieves the capacity of the rewriting model. Extensive simulations show that the rewriting performance of our scheme compares favorably with that of polar WOM code in the rate region where high rewriting success probability is desired. We further augment our coding schemes with error correction capability. By drawing a connection to the conjugate code pairs studied in the context of quantum error correction, we develop a general framework for constructing error-correction WOM codes. Under this framework, we give an explicit construction of WOM codes whose codewords are contained in BCH codes
Treatment of fecal matter by smoldering and catalytic oxidation (2020)

Abstract There is a strong need for transformative sanitation systems in the areas of the world where open defecation habits and/or inadequate sewage treatment methods and facilities exist. This paper describes an innovative thermally efficient solid waste treatment process as a basis for an off-the-grid, non-sewered toilet in order to address this need. Human feces are combusted in a continuous-cyclic manner using two stages of smoldering and catalytic oxidation. It has been shown that thermal coupling of the two stages creates a self-sustained reactor that can combust wet fecal material containing up to 3.2 parts water to 1 part dry matter – equivalent of water content in healthy human feces – without the need for external heating, known as the ultimate challenge in direct combustion of human feces. Furthermore, it has been shown that air flow rate can be reliably used as a controlling mechanism for fecal destruction rate which means the same reactor could be operated for various and varying input rates. The present work demonstrates the potential for manufacturing low-cost, low-energy consuming sanitation systems that are more easily accessible to communities in need of such systems.
Column: Polymeric Membranes (2004)

This is one of our continuing series of articles on polymeric membranes addressing pervaporation (PV) separation of organic-water mixtures. In PV, polymer membranes are used to selectively separate mixture components based on differences in partial vapor pressure or chemical potential between the liquid feed and the vapor permeate [1]. Two parameters that govern the PV process are flux, Jp and selectivity, _ defined as:
Unifying Question Answering, Text Classification, and Regression via Span Extraction (2019)

Even as pre-trained language encoders such as BERT are shared across many tasks, the output layers of question answering, text classification, and regression models are significantly different. Span decoders are frequently used for question answering, fixed-class, classification layers for text classification, and similarity-scoring layers for regression tasks, We show that this distinction is not necessary and that all three can be unified as span extraction. A unified, span-extraction approach leads to superior or comparable performance in supplementary supervised pre-trained, low-data, and multi-task learning experiments on several question answering, text classification, and regression benchmarks.
Anti-Hiv-1 Activity of 2′,3′-Dideoxinucleoside Analogues : Structure-Activity Relationship (1989)

Abstract Among the purine and pyrimidine 2′,3′-dideoxynucleosides, 2′,3′-didehydro-2′,3′-dideoxynucleosides, 3′-azido-2′,3′-dideoxynucleosides and 3′-fluoro-2′,3′-dideoxynucleosides, several congeners have been identified which achieve a potent and selective inhibition of HIV-1 replication in vitro.
Airborne testing of three antimotion sickness preparations (1976)

Thirteen human volunteers were exposed to weekly flights in which standardized, steep turns were used to produce motion sickness. A combination of promethazine hydrochloride (25 mg) plus ephedrine sulphate (25 mg) was found to be equally as effective as the combination of 1-scopolamine hydrobromide (0.35 mg) plus d-amphetamine sulphate (5 mg). Droperidol (2.5 mg) was indistinguishable from the placebo. It was concluded that the treatment of choice for motion sickness is promethazine plus ephedrine.