gebhart/patrepeval huggingface dataset:
Hemophilia trials in the twenty‐first century: Defining patient important outcomes (2019)

Treatment for hemophilia has advanced dramatically over the past 5 decades. Success of prophylactic therapy in preventing bleeding and decreasing associated complications has established a new standard of care. However, with the advent of gene therapy and treatments that effectively mimic sustained coagulation factor replacement, outcome measures that worked well for assessing factor replacement therapies in past clinical trials need to be reassessed. In addition, while therapies have advanced, so has the science of outcome assessment, including recognition of the importance of patient important and patient reported outcomes. This manuscript reviews strengths and limitations of outcome measures used in hemophilia from both a provider and patient perspective.
Black Level Compensation for TVs Using HDR Dynamic Metadata (2022)

This paper proposes a high dynamic range (HDR) tone mastering system which dynamically corrects the picture quality based on dynamic metadata in various black level conditions to preserve the content providers' creative intent. It permits compensating for the TV panel black level difference and preserving black and shadow details created by studios even though black levels vary across TV panels. The paper also describes a novel HDR image creative intent tuning system to match the content shown on target TV and reference TV. The results show that the proposed method can effectively compensate the black detail for different black levels.
Preparation of Mn‐Zn Ferrites Having a Low Temperature Coefficient of Permeability (1983)

Substitutions of Ge, and to a lesser extent Ga, for Zn in manganese‐zinc ferrite were found to increase the initial permeability (μ) from ∼200 to ∼1000. The relative temperature coefficient of permeability is very low (<0.02%) over the range ‐40° to +80°C. These desired properties are achieved without controlling the atmosphere during sintering und subsequent cooling provided rhat the utmo sphere contains ≥1 vol% 0 2 .
ATNT-21PRECLINICAL AND INITIAL PHASE 1 EXPERIENCE FOR USE OF MEBENDAZOLE AS UP FRONT THERAPY FOR HIGH GRADE GLIOMA (2015)

INTRODUCTION: Identifying drugs that can reach brain cancers in effective concentrations has been a serious challenge. There has been a body of evidence implicating anti-cancer mechanisms and utility for antihelminthics benzimidazoles, and preclinical and clinical development of repurposed mebendazole is gaining momentum. Mebendazole has been used safely as an anti-parasitic drug, and in high doses, in humans starting in 1972. METHODS: Multiple intracranial models of glioblastoma and medulloblastoma have been used for efficacy studies on intracranial tumors. Studies with orally administered mebendazole demonstrate favorable pharmacokinetics with 70 to 80% of mebendazole serum levels measured in the in the mouse brain and brain tumors. RESULTS: Our laboratory serendipitously identified benzimidazole anti-cancer activity in brain cancers and found that of the approved benzimidazoles, mebendazole showed the best survival benefit. We observe in preclinical testing it reaches effective concentrations in intracranial tumors, acts to prevent tubulin polymerization, has an additional anti-VEGR2 and anti-angiogenesis mechanisms and significantly improves survival in a variety of intracranial malignancy models. We have translated our preclinical findings into a Phase I trial, using mebendazole for upfront therapy, concurrent with temozolomide therapy for newly diagnosed patients with a high grade glioma. We have further improved mebendazole with drug combinations. CONCLUSION: The preclinical and phase 1 clinical findings are consistent with safe and possibly effective use of an improved formulation of oral mebendazole. We provide evidence that continued optimization of mebendazole based oral therapy and planning of future clinical trials may yield an additional tool for therapy of GBM and other intracranial tumors.
Reduction of Adhesion Formation by Intraperitoneal Administration of Various Anti-Inflammatory Agents (1998)

Adhesion formation is a major source of postoperative morbidity and mortality. Therefore, the reduction of postoperative adhesion formation would be of clinical benefit. Various modalities have been shown to reduce adhesion formation, including fibrinolytic enzymes, nonsteroidal anti-inflammatory drugs, and barriers that reduce the apposition of sites of potential adhesion formation. In this report, the ability of three compounds with different mechanisms of action, all-trans-retinoic acid, quinacrine, and dipyridamole, to reduce the formation of intraperitoneal adhesions was examined in two rabbit models. In the sidewall model, the medicaments were administered via an Alzet miniosmotic pump for the entire postoperative interval. With all three agents, there was a reduction in the area of the sidewall injury that was involved in adhesions to the cecum and the bowel at both doses tested. In the same model, quinacrine also reduced the area of the sidewall injury that was involved in adhesions to the cecum and the bowel. At the higher concentrations of quinacrine, there was a deposition and walling off of the quinacrine at the site of delivery. In the double uterine horn model (DUH), the medicaments were administered via an Alzet miniosmotic pump to the area of injury for either 1, 2, 3, or 7 days. Administration of all three compounds for as little as 24 h after surgery significantly reduced the extent of adhesion formation. However, there was a further reduction in the amount of adhesion when the retinoic acid or dipyridamole was administered for 72 h postoperatively. However, when the quinacrine was administered for longer times postoperatively, the amount of adhesion reduction observed was less. These studies demonstrate that postoperative administration of retinoic acid, quinacrine, or dipyridamole to the site of injury reduced the formation of postoperative adhesions in two animal models.
The Phosphatidylethanolamine-binding Protein Is the Prototype of a Novel Family of Serine Protease Inhibitors (2001)

Serine proteases are involved in many processes in the nervous system and specific inhibitors tightly control their proteolytic activity. Thrombin is thought to play a role in tissue development and homeostasis. To date, protease nexin-1 is the only known endogenous protease inhibitor that specifically interferes with thrombotic activity and is expressed in the brain. In this study, we report the detection of a novel thrombin inhibitory activity in the brain of protease nexin-1(-/-) mice. Purification and subsequent analysis by tandem mass spectrometry identified this protein as the phosphatidylethanolamine-binding protein (PEBP). We demonstrate that PEBP exerts inhibitory activity against several serine proteases including thrombin, neuropsin, and chymotrypsin, whereas trypsin, tissue type plasminogen activator, and elastase are not affected. Since PEBP does not share significant homology with other serine protease inhibitors, our results define it as the prototype of a novel class of serine protease inhibitors. PEBP immunoreactivity is found on the surface of Rat-1 fibroblast cells and although its sequence contains no secretion signal, PEBP-H(6) can be purified from the conditioned medium upon recombinant expression.
First-in-human uPAR PET: Imaging of Cancer Aggres- (2015)

A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with 64 Cu for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of 64 Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment with laboratory blood screening tests was performed before and after PET ligand injection. In a subgroup of the patients, the in vivo stability of our targeted PET ligand was determined in collected blood and urine. No adverse or clinically detectable side effects in any of the 10 patients were found. The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human study therefore provides promising evidence for safe use of 64 Cu-DOTA-AE105 for uPAR PET imaging in cancer patients.
Microfluidic tuning of distributed feedback quantum cascade lasers (2006)

In this Letter, we report the tuning of the emission wavelength of a single mode distributed feedback quantum cascade laser by modifying the mode effective refractive index using fluids. A fabrication procedure to encapsulate the devices in polymers for microfluidic delivery is also presented. The integration of microfluidics with semiconductor laser (optofluidics) is promising for new compact and portable lab-on-a-chip applications.
Identification of Novel Transcriptional Consequences of Activation and Inactivation of TP53 in Multiple Myeloma. (2007)

Abstract The genetic lesions important in the pathogenesis and prognosis of multiple myeloma (MM) continue to be elucidated. TP53 is deleted in approximately 10% of cases and is associated with a poor prognosis in MM. As a transcription factor, TP53 regulates the expression of genes involved in a variety of cellular functions, including cell-cycle arrest, DNA repair, and apoptosis. In the current study, we identified novel TP53 target genes and demonstrated the clinical relevance of alterations in this signaling pathway in disease progression. First, we examined the expression of 122 genes that were identified as direct TP53 target genes by paired-end diTags (PET) analysis and whose p53-dependent expression had been validated. The target genes were profiled in a collection of 351 newly diagnosed MM samples using the Affymetrix U133Plus2.0 microarrays. In this set of tumors, TP53 expression in the lowest 10th percentile was associated with a significantly shorter event-free (P = 0.0004) and overall survival (P = 0.0001). However, expression of only a few of the previously identified TP53 target genes correlated with TP53 expression in MM cells. This suggested that TP53 may regulate a distinct set of genes in MM. To elucidate the TP53 regulatory networks in MM, we used lentiviral transduction to over express TP53 in four MM cell lines (OCI-MY5, JJN3, ARP-1 and Delta 47). An increase in steady-state TP53 level was confirmed by Western blot analysis 24 hours post lentiviral transduction and massive cell death occurred within 36 hours. Gene expression profiling revealed that a total of 85 genes were affected by TP53 expression: 50 were up-regulated and 35 were down-regulated 1.5-fold or greater in at least 3 of 4 MM cell lines. Expression analysis of primary MM revealed that the 85 genes also exhibited differential expression in comparison of those with the lowest relative to the highest TP53 expression, suggesting that TP53 may directly or indirectly regulate the expression of these genes. Of the 85 genes, 4 genes (ZMAT3, TNFRSF10B, TRIM22, and NOTCH1) were in the group of 122 P53 target genes identified by PET analysis. Consistent with known TP53 cellular functions, we found 69 of the 85 TP53 regulated genes in MM to be involved in apoptosis, cell cycle regulation, cell growth and differentiation, DNA repair and chromatin modification, and transcription regulation. Unsupervised hierarchical clustering of 351 newly diagnosed MM and 90 relapsed MM with the 85 TP53 associated genes identified 2 subgroups in each analysis. The subtype associated with lower TP53 expression had a significantly shorter EFS (P = 0.0006) and OS (P = 0.0010) in newly diagnosed MM and shorter post-relapse survival in relapsed disease (P &lt; 0.0001). Thus we have identified MM-specific TP53 target genes by expression profiling in both cultured myeloma cells and primary tumors that correlate with clinical outcome. The identification and characterization of these pathways may lead to a better understanding of the critical role of TP53 loss in cancer.
Custom local search (2009)

Many popular online services provide "local" or "yellow-pages" search, but none of them allow users to customize the search over user-specified data. This paper describes a novel system for providing custom local search over user-provided spatial datasets logically combined with detailed street-level vector data. We present the algorithms and architecture underlying our prototype system, which handles complex queries and elegantly solves the problem of parsing terms from multiple datasets in the presence of ambiguity and misspellings. We show that the system provides custom local search with precision and recall figures that often exceed that of a commercial local search service. Further, we show that our system scales gracefully with the number of individual custom data sets being served simultaneously.
X-ray ring-focusing mirror (2019)

Mirrors used in synchrotron radiation facilities can reflect X-ray beams ideally owing to recent advancements in ultraprecise fabrication technologies. Flat mirrors can change the direction of an X-ray beam without distorting its wavefront. Elliptically figured mirrors can focus X-rays onto a spot with nanometer dimensions. The intensity distribution of a reflected X-ray beam is determined, and thus can be controlled, by the shape of the employed mirror. This study proposes, fabricates, and evaluates a ring-focusing mirror that can produce an X-ray beam with a ring-shaped intensity profile. This ring-shaped X-ray beam could be created and observed at the soft X-ray beamline BL25SU at the SPring-8 synchrotron radiation facility, Japan. The increase in the freedom of X-ray mirror shapes will lead to the development of various analytical methods and optical systems in the X-ray region.
Asymmetric zonal shim coils for magnetic resonance applications (2001)

A method is presented for the systematic design of asymmetric zonal shim coils for magnetic resonance applications. Fourier-series methods are used to represent the magnetic field inside and outside a circular cylinder of length 2L and radius a. The current density on the cylinder is also represented using Fourier series. Any desired field can be specified in advance on the cylinder's radius, over some nonsymmetric portion pL<z<qL of the coil's length (-1<p<q<1). Periodic extension of the field is used, in a way that guarantees the continuity of the field, and therefore gives good convergence of the Fourier series. All that is required is to calculate the Fourier coefficients associated with the specified desired field, and from these, the current density on the coil and the magnetic field components then follow automatically. The method is illustrated by applying it to three sample zonal coil designs, namely, linear, quadratic, and cubic fields located asymmetrically in the coil. Current densities and corresponding coil winding patterns are shown for these three illustrative cases. Field calculations directly from the coil patterns and spherical harmonic deconvolutions of these fields indicate that the example designs match the theory well. Asymmetric shim coils can be used in conventional symmetric MRI magnets, particularly those architected for "head-only" studies. One of their major applications is expected to be in the newly developed asymmetric magnet systems.
Designing Next Generation of Persistent Luminescence: Recent Advances in Uniform Persistent Luminescence Nanoparticles (2021)

Persistent luminescence is a unique optical process where long-lasting afterglow persists after the cessation of excitation. Nanoscale persistent luminescent materials are getting increased research interest from various fields due to their unique optical property. In recent years, inspiring achievements have been made to produce uniform persistent luminescence nanoparticles (PLNPs) in a controllable manner, unleashing their fascinating potential, surpassing other types of luminescent materials in a wide variety of application such as high-contrast bioimaging and high-resolution X-ray detection. In this review, the evolution of uniform PLNPs, from their bulk phosphor counterparts, to the "top-down" preparation of nanoscale persistent luminescent materials, to the recent "bottom-up" synthesis of uniform PLNPs is first summarized. The respective milestones of uniform PLNPs prepared by templated synthesis, aqueous synthesis, and colloidal synthesis are highlighted. The key optical properties that can be enhanced in uniform PLNPs, including increasing the persistent luminescence intensity, tuning the excitation irradiance, as well as the emission wavelengths are then analyzed. Detailed strategies to enhance each optical property are also discussed in various sections. Finally, future challenges are highlighted with respect to the perspectives on the development of next-generation PLNPs with novel applications.
Utility-driven evolution recommender for a constrained ontology (2013)

Ontology evolution continues to be an important problem that needs further research. Key challenges in ontology evolution and creation of a highly consumable ontology include accomodating: (a) the subtle changes in the meaning of a model element over time, (b) the changing relevance of various parts of the model to the user, and (c) the complexity in representing time-varying semantics of model elements in a dynamic domain.
Pipe support for use in a nuclear system. [LMFBR] (1977)

Disclosed is a pipe support for high temperature, thin-walled vertical piping runs used in a nuclear system. A cylindrical pipe transition member, having the same inside diameter as the thin-walled piping, replaces a portion of the piping where support is desired. The outside diameter of the pipe transition member varies axially along its vertical dimension. For a section of the axial length adjacent the upper and lower terminations of the pipe transition member, the outside diameter is the same as the outside diameter of the thin-walled piping to which it is affixed. Intermediate of the termination sections, the outside diameter increases from the top of the member to the bottom. Adjacent the lower termination section, the diameter abruptly becomes the same as the piping. Thus, the cylindrical transition member is formed to have a generally triangular shaped cross-section along the axial dimension. Load-bearing insulation is installed next to the periphery of the member and is kept in place by an outer ring clamp. The outer ring clamp is connected to pipe hangers, which provide the desired support for the vertical thin-walled piping runs.
<title>Optical method of penetration sensing for pulsed Nd:YAG laser welding</title> (1997)

The ability to monitor and control the depth of a laser weld in real-time is critical in many laser welding applications. Consequently, we have investigated the use of an optical method to sense weld depth. Welds were generated on kovar samples, using a pulsed Nd:YAG laser. The sensing method uses digital high-speed photography to measure the velocity of the plume of vaporized metal atoms ejected from the metal surface. An energy balance equation is then used to relate the plume velocity to the size of the weld. Numerical solution of the energy balance equation yielded values for weld depth that were within 8% of the actual measured values.
Business process simulation with IT depth (2005)

We propose a framework for modeling and simulating business processes with IT depth. This enables both business level and IT level users to be supported by a common approach, by developing the models at different levels of granularity. We believe that such a common approach also progress us toward reducing the gap between business and IT. This approach can be used by business users to analyze a business process to gain insight into the business process and analyze the tradeoffs between different key performance indicators. It can also be used by IT users to analyze the business process at an IT level to gain insight to the tradeoffs between performance and cost and analyze the infrastructure for sizing and capacity planning
Measuring bladder viscoelasticity using ultrasound (2012)

Increase in bladder stiffness is associated with various pathological conditions. Measuring bladder viscoelasticity could be an important step towards understanding various disease processes and improving patient care. Here, we introduce Ultrasound Bladder Vibrometry (UBV), a novel method for rapid and noninvasive measurement of bladder wall viscoelasticity. UBV uses acoustic radiation force to excite Lamb waves in the bladder wall and track the motion using ultrasound pulse-echo techniques. Fourier space analysis of the tissue motion is used to calculate the Lamb wave velocity dispersion (change of phase velocity as a function of frequency). The measured phase velocity dispersion is fit with the antisymmetric Lamb wave model to estimate tissue elasticity and viscosity. Finite element analysis of viscoelastic plates was used to study the effect of curvature on Lamb wave dispersion. The feasibility of the UBV technique was demonstrated in ex vivo and in vivo settings.
Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials (2013)

In this longitudinal study, MRI-PDFF correlated well with MRS-PDFF and was more sensitive than the histology-determined steatosis grade in quantifying increases or decreases in the liver fat content. Therefore, it could be used to quantify changes in liver fat in future clinical trials.
Coupling and Attenuation: A New Measurement Pair in Cement Bond Logging (1987)

ABSTRACT Acoustical coupling is proposed as a new measurement to complement the attenuation rate measurement now available with multispacing cement bond logging tools. Coupling responds principally to the mechanical impedance and distribution of material outside the casing, but is largely insensitive to bonding. Estimates of cement strength may be obtained even in the presence of microannulus.
Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis (2002)

In order to examine the relationship between corneodesmosin (CDSN) and psoriasis we have determined the presence of CDSN polymorphisms by DNA sequencing in (a) nine B-LCL cell lines of major histocompatibility complex ancestral haplotypes known to be associated with psoriasis vulgaris including 13.1AH, 46.1AH, 46.2 and 57.1AH, and in (b) a group of 267 unrelated individuals comprising Japanese psoriasis patients (n = 101) and Japanese subjects without the disease (n = 166). Three novel CDSN gene sequences were identified. In addition, we have classified the 18 alleles into seven main groups based on phylogeny of non-synonymous substitutions. However, we have found no statistically significant differences between the patients and the unaffected individuals in any of these groups. These findings indicate that CDSN is not a major psoriasis susceptibility gene.