gebhart/patrepeval huggingface dataset:
Photoactivated Bioconjugation Between <i>ortho</i>-Azidophenols and Anilines: A Facile Approach to Biomolecular Photopatterning (2014)

Methods for the surface patterning of small molecules and biomolecules can yield useful platforms for drug screening, synthetic biology applications, diagnostics, and the immobilization of live cells. However, new techniques are needed to achieve the ease, feature sizes, reliability, and patterning speed necessary for widespread adoption. Herein, we report an easily accessible and operationally simple photoinitiated reaction that can achieve patterned bioconjugation in a highly chemoselective manner. The reaction involves the photolysis of 2-azidophenols to generate iminoquinone intermediates that couple rapidly to aniline groups. We demonstrate the broad functional group compatibility of this reaction for the modification of proteins, polymers, oligonucleotides, peptides, and small molecules. As a specific application, the reaction was adapted for the photolithographic patterning of azidophenol DNA on aniline glass substrates. The presence of the DNA was confirmed by the ability of the surface to capture living cells bearing the sequence complement on their cell walls or cytoplasmic membranes. Compared to other light-based DNA patterning methods, this reaction offers higher speed and does not require the use of a photoresist or other blocking material.
Uncertainty management in intelligent task planning of mobile robots (1990)

Abstract This paper focuses on uncertainty associated with intelligent task planning. The proposed framework combines the theory of fuzzy reasoning and decision analysis in order to deal with the uncertainties and redundant degrees of freedom in the generation of an optimal task plan. The method applies particularly to, but is not limited to, robotic task control in a dynamic environment. First, the paper discusses the various sources of uncertainty associated with task planning. These uncertainties lead to multiple candidate task sequences with varying degrees of confidence. Redundant degrees of freedom of the machine also lead to multiple candidate task plans and thus is considered as one type of uncertainty. In order to find the optima] plan, our model first deduces the likelihood of success of each candidate plan using fuzzy reasoning. Next, we use the decision analysis technique to determine which task sequence is optimal. The paper demonstrates this idea with two examples: (1) a robot that spots a golf ball out of several candidate targets and (2) an autonomous guided vehicle (AGV) that seeks the fastest route. The AGV example introduces multiple levels of success at the chance nodes.
Determination of glycodelin-A expression correlated to grading and staging in ovarian carcinoma tissue. (2010)

Glycodelin is a glycoprotein with immunosuppressive function. In particular, serous and endometrioid tumor tissue showed strong glycodelin-A expression. In addition, glycodelin expression is reduced in G2 and FIGO III-IV stages. Therefore, glycodelin also seems to be an important marker of morphological differentiation in ovarian cancer. The use of glycodelin as a tumor marker in ovarian carcinomas is currently under investigation.
Resource Scheduling for Postdisaster Management in IoT Environment (2019)

For postdisaster management, rescue and recovery operations are very critical. It is desired that the rescue and recovery operation should be handled through efficient resource management to minimize the postdisaster effects in terms of human loss and other types of damage. Resource management requires addressing various challenging issues like scheduling and monitoring of the resources which need real time information of various activities or events occurring anytime, anywhere, and anyplace. To satisfy such requirements, Internet of Things, an advanced upcoming technology, can be utilized for resource monitoring and scheduling. In this context, we propose resource scheduling algorithm for the postdisaster management. As mentioned above various tasks of rescue and recovery operation should be carried out with different priority and there should not be deadlock while availing the resources. In our approach, we estimate the waiting time using queuing theory for the availability of the resources for different activities that are to be performed at various locations. The simulation results of the proposed method are analyzed using different standard parameters like resource utilization and the waiting time for different activities. The proposed method is further visualized through real time annotation of resources and activities represented with the help of Google maps using android based application on the smartphone. The proposed algorithm is further compared in terms of computational complexity and fairness analysis for the effective utilization of the available resources.
Dietary lipids modify the fatty acid composition of cartilage, isolated chondrocytes and matrix vesicles (1994)

The effects of dietary lipids on the fatty acid composition of hyaline cartilage, epiphyseal chondrocytes (EC) and matrix vesicles (MV) were evaluated in chicks. A basal semipurified diet was fed to chicks containing one of the following lipid sources at 70 g/kg: soybean oil, butter+corn oil, margarine+corn oil or menhaden oil+corn oil (MEC). Articular and epiphyseal growth cartilage were isolated from the proximal tibiotarsus; EC and MV were subsequently released by trypsin (EC 3.4.21.4) and collagenase (EC 3.4.24.3) digestion followed by ultracentrifugation. The fatty acid composition of polar lipids in chick epiphyseal cartilage at three and six weeks, as well as articular cartilage, EC and MV at eight weeks of age revealed the presence of high levels of saturated and monounsaturated fatty acids (up to 85.5%) but low levels of n-6 polyunsaturated fatty acids (PUFA) (2.6-10.2%). Mead acid (20:3n-9, > 3%) was also present in cartilage, EC and MV lipids, and was unaffected by the dietary lipid treatments. Total n-3 PUFA concentrations were the highest in cartilage, EC and MV of chicks consuming MEC. Feeding MEC lowered the levels of 20:4n-6 in cartilage, but increased 20:5n-3 levels. The data are consistent with those reported previously which showed that cartilage tissues are low in n-6 PUFA and that they contain 20:3n-9. We furthermore demonstrated that the PUFA composition of cartilage can be modified by dietary lipids.
Engineering graded tissue interfaces (2008)

Interfacial zones between tissues provide specialized, transitional junctions central to normal tissue function. Regenerative medicine strategies focused on multiple cell types and/or bi/tri-layered scaffolds do not provide continuously graded interfaces, severely limiting the integration and biological performance of engineered tissue substitutes. Inspired by the bone-soft tissue interface, we describe a biomaterial-mediated gene transfer strategy for spatially regulated genetic modification and differentiation of primary dermal fibroblasts within tissue-engineered constructs. We demonstrate that zonal organization of osteoblastic and fibroblastic cellular phenotypes can be engineered by a simple, one-step seeding of fibroblasts onto scaffolds containing a spatial distribution of retrovirus encoding the osteogenic transcription factor Runx2/Cbfa1. Gradients of immobilized retrovirus, achieved via deposition of controlled poly(L-lysine) densities, resulted in spatial patterns of transcription factor expression, osteoblastic differentiation, and mineralized matrix deposition. Notably, this graded distribution of mineral deposition and mechanical properties was maintained when implanted in vivo in an ectopic site. Development of this facile and robust strategy is significant toward the regeneration of continuous interfacial zones that mimic the cellular and microstructural characteristics of native tissue.
Le paysage en question (2003)

Orange Gérald. Le paysage en question. In: Études Normandes, 52e année, n°3, 2003. Paysage et Patrimoine. p. 5.
Strapped Calix[4]pyrroles Bearing a 1,3-Indanedione at a β-Pyrrolic Position: Chemodosimeters for the Cyanide Anion (2009)

A strapped calix[4]pyrrole bearing a 1,3-indanedione group at a beta-pyrrolic position has been synthesized and studied as a ratiometric cyanide-selective chemosensor. A concentration-dependent bleaching of the initial yellow color was observed upon addition of the cyanide anion. The bleaching, which was observed exclusively with the cyanide anion, occurred even in the presence of other anions. Spectroscopic studies provide support for a mechanistic interpretation wherein the cyanide anion forms a complex with the receptor (K = 2.78 x 10(4) M(-1)) through a fast equilibrium, which is followed by slow nucleophilic addition to the beta-position of the 1,3-indanedione group. A minimum inhibitory effect from other anions was observed, a feature that could be beneficial in the selective sensing of the cyanide anion.
Liquid Tin Anode Solid Oxide Fuel Cell for Direct Carbonaceous Fuel Conversion (2007)

The Liquid Tin Anode Solid Oxide Fuel Cell (LTA-SOFC) is a modified version of SOFC that allows the direct oxidation of carbonaceous fuels. The LTA-SOFC uses many conventional SOFC components but differs from conventional SOFC because its anode is liquid tin allowing directly oxidization of fuel without fuel reforming or other fuel processing. In addition, the anode stores energy, allowing the cell to deliver power in case fuel flow has been interrupted. As a result, the LTA-SOFC requires less components resulting in simpler and more efficient system. This paper describes the basic LTA-SOFC cell architecture and cell/stack test results using carbonaceous fuels such as JP-8, natural gas, coal, bio-mass and plastic feedstock.
Assessment of Similarity Indices for Undesirable Properties and a new Tripartite Similarity Index Based on Cost Functions (1997)

Comparison of lists is a common element of many studies including ethnomycological, ecological, and mycological investigations. The items on the lists might be species in a habitat, uses of a given organism by indigenous people, character states present in an individual fungus, or lists of unusual spellings in segments of the Dead Sea Scrolls. Often, it is desirable to express the similarity of two related lists by some formula (a similarity index). Such an index might be used in summarizing data otherwise presented or as input to further numerical processing, such as the creation of a dendrogram (Pankhurst, 1991:54). In examining several works using formulae to provide a single number expressing the similarity of the contents of two lists, a number of difficulties with the formulae were noted. For example, for some indices the same value was generated for two or more quite different situations, e.g., one in which a pair of lists were nearly identical, and another in which one list was much larger than the other. This problem came up during review of material for the present book, thus motivating the present chapter. The purpose of this chapter is to motivate, describe, and offer an
Data security in location-aware applications: an approach based on RBAC (2007)

Data security in a mobile context is a critical issue. Over the last few years a new category of location-based services, the Enterprise LBS (ELBS), has emerged focusing on the demands of mobility in organisations. These applications pose challenging requirements, including the need of selective access to ELBS based on the position of mobile users and spatially bounded organisational roles. To deal with these requirements a novel access control system, named GEO-RBAC, has been developed. GEO-RBAC extends the NIST RBAC (Role-Based Access Control) standard with the notions of spatial role, role-dependent position, role schema and role instance. Further, roles become enabled/disabled based on the position of the user. In the paper we present GEO-RBAC, a full-fledged RBAC-based model, consisting, like RBAC, of three distinct components: the Core GEO-RBAC, the Hierarchical GEO-RBAC and the Constrained GEO-RBAC. The paper focuses on the innovative aspects that have been introduced in the model to account for the spatial dimension. Further, a rigorous specification of the model (reference model) is presented.
The Concept of Sasang Health Index and Constitution-Based Health Assessment: An Integrative Model with Computerized Four Diagnosis Methods (2013)

SASANG CONSTITUTIONAL MEDICINE (SCM) SHARES ITS PHILOSOPHY WITH THAT OF PERSONALIZED MEDICINE: it provides constitution-specific treatment and healthcare individualized for each patient. In this work, we propose the concept of the Sasang Health Index (SHI) as an attempt to assess the individualized health status in the framework of SCM. From the target population of females in their fifties and older, we recruited 298 subjects and collected their physiological data, including complexion, radial pulse, and voice, and their questionnaire responses. The health status of each subject was evaluated by two Korean medical doctors independently, and the SHI model was obtained by combining all the integrative features of the phenotype data using a regression technique. As a result, most subjects belonged to either the healthy, subhealthy, or slightly diseased group, and the intraclass correlation coefficient between the two doctors' health scoring reached 0.95. We obtained an SHI model for each constitution type with adjusted R-squares of 0.50, 0.56, and 0.30, for the TE, SE, and SY constitution types, respectively. In the proposed SHI model, the significant characteristics used in the health assessment consisted of constitution-specific features in accordance with the classic literature and features common to all the constitution types.
Assembly of Substituted 3-Aminoindazoles from 2-Bromobenzonitrile via a CuBr-Catalyzed Coupling/Condensation Cascade Process (2013)

CuBr-catalyzed coupling reaction of 2-halobenzonitriles with hydrazine carboxylic esters and CuBr/4-hydroxy-l-proline-catalyzed coupling reaction of 2-bromobenzonitriles with N'-arylbenzohydrazides proceed smoothly at 60-90 °C to provide substituted 3-aminoindazoles through a cascade coupling/condensation (or coupling/deacylation/condensation) process. A wide range of 3-aminoindazoles with substituents at both the 1-position and the phenyl ring part can be prepared from the corresponding coupling partners.
Genetic Analysis of hook, a Gene Required for Endocytic Trafficking in Drosophila (1999)

The Drosophila hook gene encodes a novel component of the endocytic compartment. Previously identified hook alleles, which still expressed truncated Hook proteins, affected the accumulation of internalized transmembrane ligands into multivesicular bodies (MVBs). To determine the hook null phenotype, we isolated nine new hook alleles on the basis of their characteristic hooked-bristle phenotype. At least one of these alleles, hk11, is a complete loss-of-function allele. Flies carrying the hk11 allele are viable and fertile but neither transmembrane ligands nor soluble ligands accumulate in MVBs. This effect on endocytosed ligands can be mimicked by the expression of Hook proteins truncated for the N- and C-terminal domains flanking the central coiled-coil region. The importance of all three domains for Hook function was confirmed by their conservation between two Drosophila and two human Hook proteins.
Ground-fault protection — All you need to know (2018)

Industrial power systems, whether low voltage (LV) or medium voltage (MV) systems, are the backbone of any industrial facility. To keep production going and minimize downtimes, they are required to be very reliable. Therefore, it is important to deploy various protection systems to detect and react appropriately to any abnormal condition that can lead to a failure to deliver power or to a hazardous condition. Ground faults are the most common condition experienced by a power system. Hence the ability to detect and react as needed quickly is paramount. The goal of this paper is to help protection engineers, engineering consultants, and power system operators to apply ground-fault protection systems correctly while also complying with local electrical codes.
ChemInform Abstract: Effect of Ions on the Structure of Water: Structure Making and Breaking (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID 19, continues to evolve since its first emergence in December 2019. Using the complete sequences of 1,932 SARS-CoV-2 genomes, various clustering analyses consistently identified six types of the strains. Independent of the dendrogram construction, 13 signature variations in the form of single nucleotide variations (SNVs) in protein coding regions and one SNV in the 5' untranslated region (UTR) were identified and provided a direct interpretation for the six types (types I to VI). The six types of the strains and their underlying signature SNVs were validated in two subsequent analyses of 6,228 and 38,248 SARS-CoV-2 genomes which became available later. To date, type VI, characterized by the four signature SNVs C241T (5'UTR), C3037T (nsp3 F924F), C14408T (nsp12 P4715L), and A23403G (Spike D614G), with strong allelic associations, has become the dominant type. Since C241T is in the 5' UTR with uncertain significance and the characteristics can be captured by the other three strongly associated SNVs, we focus on the other three. The increasing frequency of the type VI haplotype 3037T-14408T-23403G in the majority of the submitted samples in various countries suggests a possible fitness gain conferred by the type VI signature SNVs. The fact that strains missing one or two of these signature SNVs fail to persist implies possible interactions among these SNVs. Later SNVs such as G28881A, G28882A, and G28883C have emerged with strong allelic associations, forming new subtypes. This study suggests that SNVs may become an important consideration in SARS-CoV-2 classification and surveillance.
1D09C3, an mAb specific for MHC-II. (2008)

GPC Biotech AG is developing 1D09C3, an anti-MHC class II (HLA-DR) fully human IgG4 antibody isolated by MorphoSys AG (from its HuCAL library of human antibodies), for the potential treatment of hematological malignancies. In December 2006, positive safety data from two phase I clinical trials were reported. Final phase I data were expected in mid-2007; however, no additional data have been released at the time of publication.
Studies on the growth inhibition and metabolism of 2'-deoxy-2'-fluorocytidine in cultured human lymphoblasts. (1974)

Summary The nucleoside 2′-deoxy-2′-fluorocytidine (FCdR) inhibits the growth of various human lymphoblastic cell lines in culture. FCdR is deaminated to 2′-deoxy-2′-fluorouridine and phosphorylated to the triphosphate level. Two additional FCdR-containing metabolites, comprising about 50% of the acid-soluble metabolites, were also detected. The FCdR incorporated into acid-insoluble material was primarily in DNA. Deoxycytidine protected these cell lines from growth inhibition by FCdR, but for only a limited time.
Technical note: Sinogram merging to compensate for truncation of projection data in tomotherapy imaging (2002)

An advantage of helical tomotherapy radiation therapy systems is that on-line megavoltage computed tomography (CT) images can be reconstructed to verify patient positioning. One limitation of such systems is that the field-of-view (FOV) of the photon fan-beam is limited by the aperture size of the binary multileaf collimator (MLC) used to modulate treatment beams. For patients larger than the FOV the acquired sinograms will be truncated causing artifacts in the resultant megavoltage CT images. Computer simulations are used to demonstrate that such artifacts can be eliminated or at least reduced by merging appropriately acquired truncated fan-beam sinograms to form a nontruncated parallel-beam sinogram. The necessary fan-beam sinograms are acquired with the patient translated to different offset locations within the gantry. The parallel-beam sinogram is then used to reconstruct the final CT image. The increase in patient dose due to the acquisition of more than one fan-beam sinogram can be reduced by using properly designed binary MLC fields to block redundant projection rays.
In Vivo Activity of Evernimicin (SCH 27899) against Methicillin-Resistant <i>Staphylococcus aureus</i> in Experimental Infective Endocarditis (2001)

Currently, there exist few satisfactory alternatives to vancomycin for therapy of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. We employed a rat model of aortic valve endocarditis to assess the potential efficacy of evernimicin (SCH 27899) compared with vancomycin against infection with a strain susceptible to both agents (MICs of 0.25 and 0.50 microg/ml, respectively). Infected animals were assigned to one of three groups: controls (no treatment), evernimicin at 60 mg/kg of body weight by intravenous (i.v.) infusion once daily, or vancomycin at 150 mg/kg of body weight per day by continuous i.v. infusion. Therapy was administered for 5.5 days. At the start of therapy, colony counts in vegetations were 6.63 +/- 0.44 log(10) CFU/g. In both treatment groups, bacterial density within vegetations was significantly reduced in comparison with control animals that had not been treated. Final colony counts were as follows (mean +/- standard deviation): controls, 10.12 +/- 1.51 log(10) CFU/g of vegetation; evernimicin, 7.22 +/- 2.91 log(10) CFU/g of vegetation; vancomycin, 5.65 +/- 1.76 log(10) CFU/g of vegetation. The difference between the evernimicin and vancomycin groups was not significant. These results confirmed the bacteriostatic activity of evernimicin in vivo in an experimental model of severe MRSA infection.
Rollin' Justin - Mobile platform with variable base (2009)

Research on humanoid robots for use in servicing tasks, e.g. fetching and delivery, attracts steadily more interest. With “Rollin' Justin” a mobile robotic system and research platform is presented that allows sophisticated control algorithms and dexterous manipulation. This video gives an overview of the mobile humanoid robotic system “Rollin' Justin” with special emphasis on mechanical design features, control issues and high-level system capabilities such as human robot interaction.
Culture-Positive Allergic Fungal Sinusitis (1991)

Allergic Aspergillus sinusitis is a well-defined clinical and histologic entity, although surprisingly few reported cases have yielded any fungal growth on culture. Taking advantage of recent changes in the identification and classification of certain groups of fungi, we were able to identify a specific fungal organism in 19 of 22 consecutive patients with a histologic diagnosis of allergic fungal sinusitis over the past 2 1/2 years. Aspergillus was found in only one patient, while an organism in the family of dematiaceous fungi was found in 18 patients. Of these patients, the genus Bipolaris was the most commonly represented, while Exserohilum, Curvularia, and Alternaria species were seen with less frequency. Thus, it appears that Aspergillus may not be the most common etiologic agent in allergic "Aspergillus" sinusitis. Allergic fungal sinusitis is not unusual and its incidence may be increasing. On initial clinical evaluation it may be easily mistaken for malignancy or invasive fungal disease with the potential for overly aggressive treatment. Preoperative suspicion of allergic fungal sinusitis based on clinical and roentgenographic findings along with careful communication with the mycology laboratory about the possibility of dematiaceous fungal growth are necessary for proper diagnosis.