gebhart/patrepeval huggingface dataset:
Conjugated polymer composites for use in electrophosphorescent light-emitting diodes (2004)

High performance electrophosphorescent light emitting diodes (LEDs) were demonstrated by using conjugated polymers, poly(9,9-dioctylfluorenyl-2,7-diyl) (PFO), PFO end-capped with hole-transporting moieties (HTM), PFO-HTM, and PFO end-capped with electron-transporting moieties (ETM), PFO-ETM, as the hosts and the organometallic emitter, tris-[2,5-bis-2'-(9,9'-dihexylfluorene) iridium] [Ir(HFP)<sub>3</sub>] as the guest. Electrophosphorescent LEDs fabricated from PFO, PFO-HTM, and PFO-ETM as the hosts emit red light with turn-on voltage around 5V, luminances (L) of 2040 cd/m<sup>2</sup>, 1937 cd/m<sup>2</sup> and 2487 cd/m<sup>2</sup> at 290 mA/cm<sup>2</sup> (16 V), and luminance efficiencies (LE) of 1.40 cd/A, 1.38 cd/A and 1.80 cd/A at 4.5 mA/cm<sup>2</sup> for PFO, PFO-HTM, and PFO-ETM, respectively. The results demonstrate that high performance electrophosphorescence can be obtained from conjugated polymer-based LEDs that are fabricated by processing the active materials directly from solution.
O(N/sup 3/ log N) backprojection algorithm for the 3-D Radon transform (2002)

We present a novel backprojection algorithm for three-dimensional (3-D) radon transform data that requires O(N3 log2 N) operations for reconstruction of an N x N x N volume from O(N2) plane-integral projections. Our algorithm uses a hierarchical decomposition of the 3-D radon transform to recursively decompose the backprojection operation. Simulations are presented demonstrating reconstruction quality comparable to the standard filtered backprojection, which requires O(N5) computations under the same circumstances.
HDSampler (2009)

A large number of online databases are hidden behind the web. Users to these systems can form queries through web forms to retrieve a small sample of the database. Sampling such hidden databases is widely desired for understanding the nature and quality of data stored in them. We have developed HDSampler, which to the best of our knowledge is the first practical system for sampling structured hidden web databases. It enables efficient sampling of the databases and accurate answering of aggregate queries, to provide analysts with valuable information for data analytics, as well as help power a multitude of third-party applications such as web-mashups and meta-search engines. For the purpose of this demo, we present an instance of HDSampler on Google Base - a content-rich hidden web database maintained by Google. By using HDSampler, the demo reveals a snapshot of the marginal distribution of various attributes of Google Base in a matter of minutes.
Programmable Multistable Mechanisms for Safe Surgical Puncturing (2019)

We present novel medical devices for safe surgical puncturing, in particular a cannula for the treatment of retinal vein occlusion (RVO). This passive mechanical device has an adjustable stroke and exerts a puncturing force independent of operator applied displacement. The innovative feature of this tool is that puncturing stroke is decoupled from operator input thereby minimizing the possibility of overpuncturing. This is achieved using our concept of stability programming, where the user modifies the mechanism strain energy as opposed to imposing direct displacement which is the case for standard bistable mechanisms. Ultra-fast laser three-dimensional (3D) printing is used to manufacture the needle in glass. A microfluidic channel is integrated into the needle tip for drug injection. Numerical simulations and experimental measurements validate the mechanical stability behavior of the puncture mechanism and characterize its puncturing stroke and force.
Identification of a MAGE‐1 peptide recognized by cytolytic T lymphocytes on HLA‐B*5701 tumors (2004)

"Cancer germline" genes such as those of the MAGE family are expressed in many tumors and in male germline cells but are silent in normal tissues. They encode shared tumor-specific antigens that have been used in therapeutic vaccination trials of cancer patients. We report the identification of a new MAGE-1-encoded peptide that is recognized by a cytolytic T-lymphocyte (CTL) clone on human leukocyte antigen (HLA)-B*5701. The sequence of the peptide, corresponding to position 102-112 of the MAGE-1 protein sequence, is ITKKVADLVGF. When tumor cells expressing MAGE-1 were transfected with HLA-B*5701, they were lyzed by the CTL clone, indicating that the peptide is processed in tumor cells and can, therefore, be used as a target for anti-tumoral vaccination.
A novel synthesis of trimethyl-p-benzoquinone: copper(<scp>II</scp>)–hydroxylamine catalysed oxygenation of 2,3,6-trimethylphenol with dioxygen (1989)

2,3,6-Trimethylphenol was efficiently oxygenated to trimethyl-p-benzoquinone with molecular oxygen in the presence of a catalytic amount of copper(II) chloride–hydroxylamine in an alcoholic solvent at ambient temperature.
Monoclonal Antibodies for Drug Targeting in Cancer Therapy (1988)

Monoclonal antibodies have been produced which recognise antigens associated with most types of cancer including cancer of colon, breast and lung as well as malignant melanoma of the skin and bone and soft tissue sarcomas. Originally it was anticipated that antibodies to cancer-specific markers would be obtained. This has not proved to be the case and monoclonal antibodies currently being used in clinical trials recognise tissue antigens which are preferentially, but not exclusively, associated with cancer cells. Nevertheless these antibodies are considered to have potential for the design of antibody targeting therapy in cancer by linking cytotoxic drugs to antibodies.
A bootstrap data methodology for sequential hybrid engine model building (2005)

The current evolution in on-board Propulsion Health Management (PHM) systems aimed at performing real-time engine diagnostics and prognostics has placed a greater demand on model accuracy and implementation speed. The complexities in assembling accurate physics based models for real-time operation has placed greater focus on the use of hybrid engine models employing some form of empirical modeling. A practical consideration for implementing a hybrid engine model that incorporates both physics-based and empirical components, involves the application of sequential model building for the construction of the empirical elements. This arises for the reason that sufficient engine data required to model the entire flight regime for a given engine/aircraft application is never available from one flight alone and may takes days or weeks to assemble. This paper discusses a methodology for constructing the empirical model in a sequential manner without the requirement for storing all of the original data. The method involves sequentially developing and storing a compact statistical and parametric representation of the data, as it is collected and generating representative pseudo-data samples from these models to be used in a piecewise model building process to bootstrap the model building process.
PWM inverter harmonic correction topologies for three-phase diode rectifiers (2000)

The functional operation of a range of harmonic correction topologies are described that draw sinusoidal AC supply currents using filter inductor sizes typically in the range 0.02 to 0.06 pu. The PWM inverter cell used in each of the various topologies can be operated with current ratings around 0.3 to 0.5 pu as compared with 1 pu for a standard PWM rectifier. The various topologies described have a range of potential advantages, such as: (a) low per-unit current ratings, (b) low dv/dt stresses between the rectifier DC link and the AC supply, (c) control of the rectifier output voltage and rectifier DC-link currents, (d) can be placed on top of a standard diode rectifier configuration, (e) balanced supply currents when the supply voltage is unbalanced, (f) bidirectional power flow, and (g) functionally equivalent structures using either AC or DC diode rectifier inductors. The features of the various topologies are illustrated using both circuit waveforms and performance curves.
The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings (2011)

Chronic liver diseases represent a major health problem due to cirrhosis and its complications. During the last decade, endocannabinoids and their receptors have emerged as major regulators of several pathophysiological aspects associated with chronic liver disease progression. Hence, hepatic cannabinoid receptor 2 (CB(2)) receptors display beneficial effects on alcoholic fatty liver, hepatic inflammation, liver injury, regeneration and fibrosis. Cannabinoid receptor 1 (CB(1)) receptors have been implicated in the pathogenesis of several lesions such as alcoholic and metabolic steatosis, liver fibrogenesis, or circulatory failure associated with cirrhosis. Although the development of CB(1) antagonists has recently been suspended due to the high incidence of central side effects, preliminary preclinical data obtained with peripherally restricted CB(1) antagonists give real hopes in the development of active CB(1) molecules devoid of central adverse effects. CB(2) -selective molecules may also offer novel perspectives for the treatment of liver diseases, and their clinical development is clearly awaited. Whether combined treatment with a peripherally restricted CB(1) antagonist and a CB(2) agonist might result in an increased therapeutic potential will warrant further investigation.
Free-Breathing Liver Perfusion Imaging Using 3-Dimensional Through-Time Spiral Generalized Autocalibrating Partially Parallel Acquisition Acceleration (2015)

This high-spatiotemporal resolution free-breathing 3D liver imaging technique allows voxelwise quantification of liver perfusion.
Marinisporolides, Polyene-Polyol Macrolides from a Marine Actinomycete of the New Genus <i>Marinispora</i> (2008)

Two new polyene macrolides, marinisporolides A and B (1, 2), were isolated from the saline culture of the marine actinomycete, strain CNQ-140, identified as a member of the new marine genus Marinispora. The marinisporolides are 34-membered macrolides composed of a conjugated pentaene and several pairs of 1,3-dihydroxyl functionalities. Marinisporolide A (1) contains a bicyclic spiro-bis-tetrahydropyran ketal functionality, while marinisporolide B (2) is the corresponding hemiketal. The structures of these new compounds were assigned by combined spectral and chemical methods including extensive 2D NMR experiments and correlations of (13)C NMR data with Kishi's Universal NMR Database. Chemical modifications, including methanolysis, acetonide formation, and application of the modified Mosher method, provided the full stereostructures of these molecules. Three additional macrolides, marinisporolides C-E (3-5), which are olefin geometric isomers of marinisporolide A (1), were also isolated and their structures defined. Under room light, marinisporolides A and B readily photoisomerize to C-E indicating that they are most likely produced by photochemical conversion during the cultivation or isolation procedures. Although polyenes, marinisporolides A (1) and B (2) showed weak to no antifungal activity against Candida albicans.
HMM-based speech recognition using state-dependent, discriminatively derived transforms on mel-warped DFT features (1997)

In the study reported in this paper, we investigate interactions of front-end feature extraction and back-end classification techniques in hidden Markov model-based (HMM-based) speech recognition. The proposed model focuses on dimensionality reduction of the mel-warped discrete Fourier transform (DFT) feature space subject to maximal preservation of speech classification information, and aims at finding an optimal linear transformation on the mel-warped DFT according to the minimum classification error (MCE) criterion. This linear transformation, along with the HMM parameters, are automatically trained using the gradient descent method to minimize a measure of overall empirical error counts. A further generalization of the model allows integration of the discriminatively derived state-dependent transformation with the construction of dynamic feature parameters. Experimental results show that state-dependent transformation on mel-warped DFT features is superior in performance to the mel-frequency cepstral coefficients (MFCC's). An error rate reduction of 15% is obtained on a standard 39-class TIMIT phone classification task, in comparison with the conventional MCE-trained HMM using MFCC's that have not been subject to optimization during training.
Spatial heterodyne planar waveguide spectrometer: theory and design (2008)

We review the theory and design of a novel type of stationary spectrometer in planar optical waveguides. These spatial heterodyne spectrometers are based on arrayed Mach-Zehnder interferometers and offer high resolution and increased optical throughput (etendue). A stationary Fourier technique is employed to reconstruct the input spectrum from the Mach-Zehnder outputs. Calibration mitigates waveguide fabrication errors and can be readily implemented in the spectra retrieval algorithm. Sensitivity to errors calibration measurements is numerically simulated.
The generation and analysis of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic (2015)

Meeting abstracts We have reported on a novel adenovirus serotype 5 (Ad5) vector gene delivery platform (Ad5 [E1-, E2b-]), in which regions of the early 1 (E1), early 2 (E2b), and early 3 (E3) genes have been deleted. The unique deletions in this platform result in a dramatic decrease in late gene
Development of 12Cr Steel Casing Castings for Advanced Steam Turbines (1990)

In order to determine the suitable manufacturing condition of 12%Cr alloy steel casing castings for advanced steam turbines, which improve efficiency for fossil fuel power plant by increasing steam condition, the research into chemistry, heat treatment and welding was carried out, and a partial model casting manufactured by this steel was evaluated.The laboratory test results indicated that the elevated temperature tensile strength and the room-temperature toughness were directly related to the room-temperature tensile strength. The stress rupture strength was found to be proportional to the tensile strength as well as the tendency toward increasing number of precipitates. The weldability of 12%Cr cast steel was likely to be the same as that of ordinary 1%CrMoV cast steels.On the base of laboratory studies and the evaluation of a partial model casing, 12%Cr alloy steel casing casting were successfully manufactured offering the integrity and the excellent creep rupture strength.
A new articulated elbow external fixation technique for difficult elbow trauma. (2001)

Articulated external fixation of the elbow allows aggressive elbow range of motion while protecting the joint and periarticular structures from excessive forces. A technique for aligning a monolateral-hinged fixator to the rotational axis of the elbow without the use of an invasive axis pin has been developed. Thirteen patients with acute and chronic post-traumatic elbow problems were treated over a four year period with this technique. An average arc of motion of 84 degrees was achieved in the frame. Frames were removed at an average of 7.6 weeks. Complications were confined to pin tract infections. In 11 patients followed for an average of 35 weeks the average arc of motion was 81 degrees. Further experience is required to determine the role of this device and to identify which elbows achieve the most benefit compared to conventional techniques.
Genomic and cDNA clones for maize phospho <i>enol</i> pyruvate carboxylase and pyruvate,orthophosphate dikinase: Expression of different gene-family members in leaves and roots (1986)

We have isolated cDNA clones for the maize leaf enzymes phosphoenolpyruvate (P-ePrv) carboxylase [orthophosphate:oxaloacetate carboxy-lyase (phosphorylating) EC 4.1.1.31] and pyruvate,orthophosphate (Prv,P(i)) dikinase (ATP:pyruvate,orthophosphate phosphotransferase, EC 2.7.9.1) by exploiting the light-inducibility and large size of the mRNAs (3.5 kilobases) that encode the two enzymes. The clones were identified by hybrid-selection and immunoprecipitation assays. From a maize genomic library, two different types of genomic clones were screened with both the P-ePrv carboxylase and the Prv,P(i) dikinase cDNA clones. Information from these genomic clones and genome blots indicates that the P-ePrv carboxylase gene family has at least three members and the Prv,P(i) dikinase family at least two. Transcripts for both enzymes were detected in green leaves, etiolated leaves, and roots. The results show that the P-ePrv carboxylase mRNAs in green leaves and roots are encoded by different genes. Whereas the P-ePrv carboxylase mRNAs in all three tissues appear to be the same size, the Prv,P(i) dikinase mRNA in green leaves is about 0.5 kilobases longer than the Prv,P(i) dikinase mRNAs in etiolated leaves and roots. It is possible that all these Prv,P(i) dikinase transcripts are encoded by one gene, and the size differences may correspond to the presence or absence of a sequence encoding a chloroplast transit peptide.
Low Loss Optical Waveguides By Direct Ti Ion Implantation In LiNbO 3 (1988)

The maximum Ti concentration and corresponding An as well as the minimum waveguide size is limited in diffused waveguides by the diffusion coefficient. Ion implantation offers an interesting alternative with a clear advantage at larger wavelengths for smaller waveguide cross-sections. Both planar and channel waveguides have been fabricated by ion implantation of Ti into a LiNb0<sub>3</sub> substrate. A solid phase epitaxial regrowth of the implant induced crystal damage resulted in excellent waveguides with propagation losses of< 1 db/cm. Guide depth of <1 micron and An of 0.04 have been achieved. Fabrication techniques and optical properties of the waveguides are presented.
Brush seals in industrial gas turbines (1997)

Brush seals have demonstrated reductions in parasitic leakage flow in aircraft engines. The same benefits in leakage reduction and performance improvement can be realised in industrial gas turbines. Moreover, as a baseload machine will typically run in excess of 8000 hours per year, the value of the resulting fuel savings and/or extra power generated is significant. While the application of brush seals to industrial gas turbines is conceptually similar to that to aircraft engines, there are some important differences. These include larger diameters and thicknesses, larger tolerance bands, split casings with the accompanying ellipticity and segmented seals, fewer transient excursions, constant synchronous speed, no landing or maneuver loads, longer operating life requirements, and, in the case of field retrofitting, the robustness to withstand field installation. Brush seals have been designed for and installed in the GE E Class turbine high pressure packing (compressor discharge) and middle bearing locations. The development included tribological tests, leakage tests, secondary flow path modelling, and field tests. Results from field installations to date and from the marketplace are very positive.
Coffee and tomato share common gene repertoires as revealed by deep sequencing of seed and cherry transcripts (2005)

An EST database has been generated for coffee based on sequences from approximately 47,000 cDNA clones derived from five different stages/tissues, with a special focus on developing seeds. When computationally assembled, these sequences correspond to 13,175 unigenes, which were analyzed with respect to functional annotation, expression profile and evolution. Compared with Arabidopsis, the coffee unigenes encode a higher proportion of proteins related to protein modification/turnover and metabolism-an observation that may explain the high diversity of metabolites found in coffee and related species. Several gene families were found to be either expanded or unique to coffee when compared with Arabidopsis. A high proportion of these families encode proteins assigned to functions related to disease resistance. Such families may have expanded and evolved rapidly under the intense pathogen pressure experienced by a tropical, perennial species like coffee. Finally, the coffee gene repertoire was compared with that of Arabidopsis and Solanaceous species (e.g. tomato). Unlike Arabidopsis, tomato has a nearly perfect gene-for-gene match with coffee. These results are consistent with the facts that coffee and tomato have a similar genome size, chromosome karyotype (tomato, n=12; coffee n=11) and chromosome architecture. Moreover, both belong to the Asterid I clade of dicot plant families. Thus, the biology of coffee (family Rubiacaeae) and tomato (family Solanaceae) may be united into one common network of shared discoveries, resources and information.
An Alternate Process for the Solid‐Phase Synthesis and Solid‐Phase Purification of Synthetic Nucleic Acid Sequences (2023)

The chemical synthesis of a riboside phosphoramidite has been achieved to provide a 5-O-capture linker and a 2-O-silyl ether protecting group with the intent of enabling an efficient solid-phase purification of synthetic DNA sequences. The riboside phosphoramidite has been incorporated into a DNA sequence while performing the penultimate automated solid-phase synthesis cycle of the sequence. The terminal 5-O-riboside moiety of the resulting DNA sequence is then conjugated to a capture linker to create an anchor for the solid-phase purification of the DNA sequence conjugate. Release of all DNA sequences from the synthesis support is achieved under standard basic conditions to yield a mixture of the desired DNA sequence conjugate along with unconjugated, shorter-than-full-length sequence contaminants. Upon exposure of all DNA sequences to a capture solid support, only the DNA sequence conjugate is chemoselectively captured, thereby allowing the unconjugated shorter-than-full-length DNA sequences to be efficiently washed away from the capture support. After 2-O-cleavage of the silyl ether protecting group from the terminal riboside ethylphosphate triester conjugate, the solid-phase-purified DNA sequence is efficiently released from the capture support through an innovative intramolecular cyclodeesterification of the ethylphosphate triester, prompted by the riboside's rigid cis-diol conformer, to provide a highly pure DNA sequence. Published 2023. This article is a U.S. Government work and is in the public domain in the USA. Basic Protocol 1: Preparation of 5-O-(4,4'-dimethoxytrityl)-2-O-tert-butyldimethylsilyl-1,4-anhydro-D-ribitol (3) Basic Protocol 2: Preparation of 5-O-(4,4'-dimethoxytrityl)-2-O-tert-butyldimethylsilyl-3-O-[(N,N-diisopropylamino)ethyloxyphosphinyl]-1,4-anhydro-D-ribitol (6). Basic Protocol 3: Automated synthesis of the chimeric solid-phase-linked DNA sequence 8. Support Protocol: Preparation of 2-cyanoethyl-(5-oxohexyl)-N,N-diisopropylphosphoramidite (9). Basic Protocol 4: Solid-phase purification of the chimeric DNA sequence 10.