gebhart/patrepeval huggingface dataset:
Time Delay Compensation for Closed-Loop Insulin Delivery Systems: A Simulation Study (1991)

Closed loop insulin therapy certainly represents the best possible approach to insulin replacement. However, present limitations preclude wider application of the so-called artificial pancreas. Therefore, a thorough understanding of these limitations is needed to design better systems for future long-term use. The present simulation study was design: to obtain better information on the impact of the measurement delay of currently available closed-loop devices both during closed-loop insulin delivery and blood glucose clamp studies, and to design and test a time delay compensator based on the method originally described by O.J. Smith. Simulations were performed on a Compaq Deskpro 486/25 personal computer under MS-DOS operating system using Simnon rel. 3.00 software. There was a direct relationship between measurement delay and amount of insulin delivered, i.e., the longer the delay the higher the insulin dose needed to control a rise in blood glucose; the closed-loop response in presence of a time delay was qualitatively impaired both during insulin delivery and blood glucose clamp studies; time delay compensation was effective in reducing the insulin dose and improving controller stability during the early phase of clamp studies. However, the robustness of a Smith's predictor-based controller should be carefully evaluated before implementation in closed-loop systems can be considered.
Reliability characteristics of 150GHz fT/fmax Heterojunction Bipolar Transistors under reverse, forward and mixed-mode stress (2006)

International audience
Low-divergence coherent soft x-ray source at 13 nm by high-order harmonics (2003)

We have generated a few tens of nanojoules of coherent soft x-ray pulses at a wavelength around 13 nm with high-order harmonics. Output energy was estimated to be 25 nJ/pulse at the 59th harmonic (13.5 nm), and the beam divergence was measured to be 0.35 mrad full width at half maximum. Since a Mo/Si mirror covers two harmonics in the high reflectivity region, we can use ∼50 nJ harmonic energy per pulse in the 13 nm wavelength. This high-coherent low-emittance x-ray source is useful for the characterization and inspection of an optical system for extreme-ultraviolet lithography.
Aspirin activates the NF- B signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer (2006)

Substantial evidence indicates that aspirin has antitumour activity against large bowel cancer and modulation of the NF-kappaB (NF-kappaB) signalling pathway has been identified as a key mechanism in this effect. However, studies examining how aspirin affects the NF-kappaB pathway to promote apoptosis have been restricted to in vitro analysis in tissue culture systems and have produced contrasting results. Here, we employed two animal models of human colorectal cancer to determine aspirin effects on the NF-kappaB pathway in colorectal neoplasia in vivo, and the relationship of such effects to the induction of apoptosis. We demonstrate that aspirin induces phosphorylation and degradation of cytoplasmic IkappaBalpha in xenografted HT-29 tumours and in adenomas from APC(Min+/-) mice. Furthermore, we show that this response occurs in a time-dependent manner and is paralleled by nuclear translocation of p65 and caspase activation. Using high performance liquid chromatography analysis, we demonstrate that >0.5 mM salicylate levels are achievable in xenografted tumours after low-dose aspirin (40 mg/kg) treatment and that these levels, which are pharmacologically relevant to humans, are sufficient to stimulate an NF-kappaB and apoptotic response. We demonstrate that activation of the NF-kappaB pathway is associated with increased apoptosis in neoplastic epithelial cells, but found that aspirin has a minimal effect on nuclear p65 and apoptosis in normal intestinal mucosa from APC(Min+/-) mice. These in vivo findings further establish that aspirin induces activation of the NF-kappaB pathway in neoplastic epithelial cells and provide further support that this effect is important for the antitumour activity of the agent. These data have considerable relevance to cancer prevention and therapy.
ModiFiber (2019)

Despite thin-line actuators becoming widely adopted in different Human-Computer Interaction (HCI) contexts, including integration into fabrics, paper art, hinges, soft robotics, and human hair, accessible line-based actuators are very limited beyond shape memory alloy (SMA) wire and motor-driven passive tendons. In this paper, we introduce a novel, yet simple and accessible, line-based actuator. ModiFiber is a twisted-then-coiled nylon thread actuator with a silicone coating. This composite thread actuator exhibits unique two-way reversible shrinking or twisting behaviors triggered by heat or electrical current (i.e., Joule heating). ModiFiber is soft, flexible, safe to operate and easily woven or sewn, hence it has a great potential as an embedded line-based actuator for HCI purposes. In this paper, we explain the material mechanisms and manufacturing approaches, followed by some performance tests and application demonstrations.
The Tribolium castaneum cell line TcA: a new tool kit for cell biology (2014)

The red flour beetle, Tribolium castaneum, is an agriculturally important insect pest that has been widely used as a model organism. Recently, an adherent cell line (BCIRL-TcA-CLG1 or TcA) was developed from late pupae of the red flour beetle. Next generation transcriptome sequencing of TcA cells demonstrated expression of a wide variety of genes associated with specialized functions in chitin metabolism, immune responses and cellular and systemic RNAi pathways. Accordingly, we evaluated the sensitivity of TcA cells to dsRNA to initiate an RNAi response. TcA cells were highly sensitive to minute amounts of dsRNA, with a minimum effective dose of 100 pg/mL resulting in significant suppression of gene expression. We have also developed a plasmid containing two TcA-specific promoters, the promoter from the 40S ribosomal protein subunit (TC006550) and a bi-directional heat shock promoter (TcHS70) from the intergenic space between heat shock proteins 68a and b. These promoters have been employed to provide high levels of either constitutive (TC006550) or inducible (TcHS70) gene expression of the reporter proteins. Our results show that the TcA cell line, with its sensitivity to RNAi and functional TcA-specific promoters, is an invaluable resource for studying basic molecular and physiological questions.
Supplying Local Microphysics Parameterizations with Information about Subgrid Variability: Latin Hypercube Sampling (2005)

Abstract One problem in computing cloud microphysical processes in coarse-resolution numerical models is that many microphysical processes are nonlinear and small in scale. Consequently, there are inaccuracies if microphysics parameterizations are forced with grid box averages of model fields, such as liquid water content. Rather, the model needs to determine information about subgrid variability and input it into the microphysics parameterization. One possible solution is to assume the shape of the family of probability density functions (PDFs) associated with a grid box and sample it using the Monte Carlo method. In this method, the microphysics subroutine is called repeatedly, once with each sample point. In this way, the Monte Carlo method acts as an interface between the host model’s dynamics and the microphysical parameterization. This avoids the need to rewrite the microphysics subroutines. A difficulty with the Monte Carlo method is that it introduces into the simulation statistical noise or variance, associated with the finite sample size. If the family of PDFs is tractable, one can sample solely from cloud, thereby improving estimates of in-cloud processes. If one wishes to mitigate the noise further, one needs a method for reduction of variance. One such method is Latin hypercube sampling, which reduces noise by spreading out the sample points in a quasi-random fashion. This paper formulates a sampling interface based on the Latin hypercube method. The associated family of PDFs is assumed to be a joint normal/lognormal (i.e., Gaussian/lognormal) mixture. This method of variance reduction has a couple of advantages. First, the method is general: the same interface can be used with a wide variety of microphysical parameterizations for various processes. Second, the method is flexible: one can arbitrarily specify the number of hydrometeor categories and the number of calls to the microphysics parameterization per grid box per time step. This paper performs a preliminary test of Latin hypercube sampling. As a prototypical microphysical formula, this paper uses the Kessler autoconversion formula. The PDFs that are sampled are extracted diagnostically from large-eddy simulations (LES). Both stratocumulus and cumulus boundary layer cases are tested. In this diagnostic test, the Latin hypercube can produce somewhat less noisy time-averaged estimates of Kessler autoconversion than a traditional Monte Carlo estimate, with no additional calls to the microphysics parameterization. However, the instantaneous estimates are no less noisy. This paper leaves unanswered the question of whether the Latin hypercube method will work well in a prognostic, interactive cloud model, but this question will be addressed in a future manuscript.
Optical properties of hair: effect of treatments on luster as quantified by image analysis. (2003)

Image analysis has been employed to measure the luster of hair simulated by light reflected from a curved hair tress. Hair samples (up to four) were mounted side-by-side in a special sample holder in the form of a cylinder and illuminated by a uniform beam of white light. Digital images of hair tresses were captured with a high-resolution camera and were analyzed by scanning across highlighted and dark areas of the resultant image using image analysis software with developed macros. Plots, similar to goniophotometric scattering curves, were used to calculate luster values according to previously published work by Nickerson, Stamm, and Reich-Robbins. Both the Stamm and Reich-Robbins approaches were found to give similar results, while the Nickerson gloss parameter exhibited less sensitivity to hair modification with cosmetic ingredients. The procedure was employed to assess the luster of natural white, light blonde, light brown, medium brown, and dark brown hair, and revealed an increase in luster indices in proportion to an increase in fiber pigmentation. Cosmetic oils such as phenyl trimethicone, amodimethicone, and castor oil were also found to increase the luster of hair as a result of the change in contrast between specular and diffuse reflection. Styling resins such as butyl ester of PVM/MA copolymer, vinyl caprolactam/PVP/dimethylaminoethyl methacrylate copolymer, and isobutylene/ethylmaleimide/hydroxyethylmaleimide copolymer were shown to increase hair gloss by a similar mechanism, as evidenced by calculated higher values of the Stamm and Reich-Robbins luster parameters. An effect of hair dulling by deposition of micronized ZnO at various concentrations, as well as by synthetic sebum, is also discussed.
Antibody interference in thyroid assays: a potential for clinical misinformation (1998)

Measurements of thyrotropin and of total and free thyroxine and triiodothyronine are widely used diagnostic methods for thyroid function evaluation. However, some serum samples will demonstrate a nonspecific binding with assay reagents that can interfere with the measurement of these hormones. Several recent case reports have described the presence of such interferences resulting in reported abnormal concentrations of thyroid hormones inconsistent with the patient's thyroid state. Circulating thyroid hormone autoantibodies, described in thyroid and nonthyroid disorders, are an important class of interference factor and can bind to hormone tracers used in various immunoassays. Two additional categories of interfering antibodies may particularly interfere within two-site immunoassays for thyrotropin. These include heterophile antibodies, especially human anti-mouse antibodies, and rheumatoid factors, which can cause interferences by immunoglobulin aggregation and (or) cross-linking of both capture and signal antibodies. Here we review the nature of these disturbances; their occurrence, prevalence, and detection; and the clinical consequences of the failure to recognize such interference.
"Cooperative security": a model for the new enterprise (2002)

Enterprise security solutions no longer come "one-size-fits-all." The prospect of universal and virtually free connectivity via the Internet is driving a profound change in the business requirements for any enterprise-wide security architecture. The authors introduce the concept of "cooperative" security-an amalgam of shared and public key systems-and its application in the design of Windows NT 5. The core principle behind this new way of looking at security is that clients, servers, and administrators must adapt and play different roles in the evaluation of trust decisions based on changing security contexts.
Computer implementation in education: Hearing the educator's voice (2003)

Computer technology is pervasive in education systems around the world. Although computers are now available in almost every school, that presence has not guaranteed the use of computers as part of the instructional repertoire of educators. This thesis is an investigation of the factors that affect implementation of computers from the perspective of educators across a school board. Fifty-four randomly selected educators (37 elementary and 17 secondary) completed a written survey assessing computer access and use, predictors of integration, prevalence of barriers and supports, and, recommendations from the educators themselves. Results indicated that computers are indeed available and that educators are technology users who generally support the integration of computers. Those educators who are more comfortable with computers are more likely to integrate them in their teaching. Educators suggested that support is necessary in terms of computer hardware and software, technical assistance, classroom access, and human resources. Training, more specifically at the elementary level, was presented as a pressing need. Educators also participated in focus group discussions. The qualitative data supported and expanded on the results of the survey. A great deal of affect accompanied the comments during the focus groups. Additionally, thematic analysis of the qualitative data resulted in the construction of a framework for future investigation of computer implementation and recommendations for policy. Within this framework, the educator is key to successful implementation, affected by both individual characteristics (time, pedagogy, training, familiarity with computers, and affect) and environmental issues (context of computers, support, curriculum, teaching level and student characteristics). The interaction of these individual and environmental variables and how they affect computer implementation is the focus of future research.
Design and fabrication of high-performance diamond triple-gate field-effect transistors (2016)

The lack of large-area single-crystal diamond wafers has led us to downscale diamond electronic devices. Here, we design and fabricate a hydrogenated diamond (H-diamond) triple-gate metal-oxide-semiconductor field-effect transistor (MOSFET) to extend device downscaling and increase device output current. The device's electrical properties are compared with those of planar-type MOSFETs, which are fabricated simultaneously on the same substrate. The triple-gate MOSFET's output current (174.2 mA mm<sup>-1</sup>) is much higher than that of the planar-type device (45.2 mA mm<sup>-1</sup>), and the on/off ratio and subthreshold swing are more than 10<sup>8</sup> and as low as 110 mV dec<sup>-1</sup>, respectively. The fabrication of these H-diamond triple-gate MOSFETs will drive diamond electronic device development forward towards practical applications.
The Role of Proteolysis in Alzheimer’s Disease (2006)

Alzheimer's disease is characterised by the progressive deposition of the 4 kDa beta-amyloid peptide (A beta) in extracellular senile plaques in the brain. A beta is derived by proteolytic cleavage of the amyloid precursor protein (APP) by various proteinases termed secretases. alpha-Secretase is inhibited by hydroxamate-based zinc metalloproteinase inhibitors such as batimastat with I50 values in the low micromolar range, and displays many properties in common with the secretase that releases angiotensin converting enzyme. A cell impermeant biotinylated derivative of one such inhibitor completely blocked the release of APP from the surface of neuronal cells, indicating that alpha-secretase cleaves APP at the cell-surface. A range of hydroxamate-based compounds have been used to distinguish between alpha-secretase and tumour necrosis factor-alpha convertase, a member of the ADAMs (a disintegrin and metalloproteinase-like) family of zinc metalloproteinases. Recent data suggests that the presenilins may be aspartyl proteinases with the specificity of gamma-secretase. Although APP and the presenilins are present in detergent-insoluble, cholesterol- and glycosphingolipid-rich lipid rafts, they do not behave as typical lipid raft proteins, and thus it is unclear whether these membrane domains are the sites for proteolytic processing of APP.
Mutated cytochrome b as a determinant of a new monoclonal antibody (H8.98) on renal carcinoma cell lines recognized by a Vγ3Vδ1 T‐cell clone (1999)

We generated a monoclonal antibody (MAb), H8.98, that recognizes an antigen shared by 50% of examined renal carcinoma cell (RCC) lines and is susceptible to lysis by a Vγ3Vδ1+ T-cell clone derived from RCC tumor-infiltrating lymphocytes. H8.98 inhibited Vγ3Vδ1+ T-cell clone–mediated lysis of RCC lines. It did not stain normal kidney lines, melanomas, fibroblasts, Burkitt's lymphoma or Epstein-Barr virus–transformed B-cell lines but it did stain 2 of 4 tested breast cancer lines. Through screening of a renal carcinoma cDNA library using H8.98, we isolated a cDNA clone which, upon sequencing, was found to be cytochrome b with 2 point mutations. Int. J. Cancer 82:562–568, 1999. © 1999 Wiley-Liss, Inc.
A war it was always going to lose: why Japan attacked America in 1941 (2011)

Jeffrey Record has specialised in investigating the causes of war. In Specter of Munich: Reconsidering the Lessons of Appeasing (Potomac Books, Inc., 2006), he contended that Hitler could not have been deterred from going to war by any action the Allies could plausibly have taken. In Beating Goliath: Why Insurgencies Win (Potomac Books, Inc., 2007), Record reviewed eleven insurgencies and evaluated the reasons for their success or failure, including the insurgents' stronger will to prevail. Wanting War: Why the Bush Administration Invaded Iraq (Potomac Books, Inc., 2009) includes one of Record's most cogent explanations of why an often uncritical belief in one's own victory is frequently (but not always) a critical component of the decision to make war. Record incorporates the lessons of these earlier books in his latest,A War It Was Always Going to Lose: Why Japan Attacked America in 1941. The attack on Pearl Harbour is one of the most perplexing cases in living memory of a weaker power seeming to believe that it could vanquish a clearly superior force. On closer inspection, however, Record finds that Japan did not believe it could win; yet, the Japanese imperial command decided to attack the United States anyway. Record finds conventional explanations that Japan's leaders were criminally stupid, wildly deluded, or just plumb crazy don't fully answer all our questions. Instead, he argues, the Japanese were driven by an insatiable appetite for national glory and economic security via the conquest of East Asia. The scope of their ambitions and their fear of economic destruction overwhelmed their knowledge that the likelihood of winning was slim and propelled them into a war they were always going to lose.
Zur Reaktivität elektronenreicher Olefine, 8.Reaktionen von Ethylentetraminen mit Sulfonamiden und phosphororganischen Verbindungen (1978)

Abstract Die Ethylentetramine 1a‐c reagieren mit den Sulfonsäure‐ oder Phosphorsäureamiden 5a‐c bzw. 10a‐d zu den Sulfonyl‐ bzw. Phosphorylformamidinen 6a‐e bzw. 11a‐h . Analog liefern die (Ethyl)thiophosphonsäureamide 12a, b die Phosphonylformamidine 13a, b . Die Dialkylphosphite 14a‐c liefern dagegen mit 1a die 2‐Imidazolidinylphosphonsäureester 15a‐c .
Insecticidal and antifeedant bioactivities of neem oils and their relationship to azadirachtin content (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInsecticidal and antifeedant bioactivities of neem oils and their relationship to azadirachtin contentMurray B. Isman, Opender Koul, Anna Luczynski, and Jerzy KaminskiCite this: J. Agric. Food Chem. 1990, 38, 6, 1406–1411Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/jf00096a024https://doi.org/10.1021/jf00096a024research-articleACS PublicationsRequest reuse permissionsArticle Views1325Altmetric-Citations317LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microbial Pathogenesis: Genomics and Beyond (1997)

The growing number of complete microbial genome sequences provides a powerful tool for studying the biology of microorganisms. In combination with assays for function, genomic-based approaches can facilitate efficient and directed research strategies to elucidate mechanisms of bacterial pathogenicity. As genomic information accrues, the challenge remains to construct a picture of the biology that accurately reflects how individual genes collaborate to create the complex world of microbial specialization.