gebhart/patrepeval huggingface dataset:
Effect of Calcium Sulfate-Chitosan Composite: Pellet on Bone Formation in Bone Defect (2005)

The purpose of this experiment was to study the effects of chitosan, calcium sulfate, and calcium sulfate-chitosan composite pellet on the osteogenesis of defective tibia in rabbits. Eighty New Zealand white rabbits, each weighing approximately 3 to 3.5 kg, were used for this study. A 1-cm ostectomy was made on the middle of the tibia of each rabbit with the periosteum preserved. Nothing was implanted in the control group (group 1), and five chitosan pellets (60 mg/pellet) were implanted in group 1, three OsteoSet pellets (100 mg/pellet) in group 3, and four calcium sulfate-chitosan composite pellets (1 pellet, 80 mg; calcium sulfate 40 mg/pellet, chitosan 40 mg/pellet) in group 4. For each group, a radiographic study, bone mineral density test, three-point bending test, and histologic examination were performed in the second, fourth, and sixth weeks. In the radiologic study, in group 1, cortical bone was not formed even at 6 weeks. In group 2, it was observed at 6 weeks. In groups 3 and 4, cortical bone was partially seen around the fourth week. At 6 weeks, it was clearly observed on both sides, and the projection of the marrow cavity became distinctive, so bone consolidation was considered to be much progressed. The bone mineral density test and three-point bending test results appeared to be highly similar in groups 3 and 4 and in groups 2 and 1. Particularly at 6 weeks, the measures for groups 3 and 4 were statistically significant compared with those for groups 1 and 2 (P < 0.05). In histologic examination, new bone formation began to be seen at 2 weeks in all groups, but it was more active and faster in groups 3 and 4. At 6 weeks, fibrous connective tissue still remained at the center in groups 1 and 2; however, the fibrous connective tissue at the center was replaced with callus, the bony bridge was obvious, and lamellation of callus was observed more in groups 3 and 4. The results indicate that chitosan pellets, OsteoSet, and chitosan-calcium sulfate composite pellets facilitate new bone formation on defected bone, and that particularly OsteoSet and chitosan-calcium sulfate composite pellets are more effective than chitosan.
Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation (2011)

Findings from this paper demonstrate that patient LQT2-hiPSC cardiomyocytes respond appropriately to clinically relevant pharmacology and will be a valuable human in vitro model for testing experimental drug combinations.
Bacillus subtilis CheC and FliY Are Members of a Novel Class of CheY-P-hydrolyzing Proteins in the Chemotactic Signal Transduction Cascade (2004)

Rapid restoration of prestimulus levels of the chemotactic response regulator, CheY-P, is important for preparing bacteria and archaea to respond sensitively to new stimuli. In an extension of previous work (Szurmant, H., Bunn, M. W., Cannistraro, V. J., and Ordal, G. W. (2003) J. Biol. Chem. 278, 48611-48616), we describe a new family of CheY-P phosphatases, the CYX family, that is widespread among the bacteria and archaea. These proteins provide another pathway, in addition to the ones involving CheZ of the gamma- and beta-proteobacteria (e.g. Escherichia coli) or the alternative CheY that serves as a "phosphate sink" among the alpha-proteobacteria (e.g. Sinorhizobium meliloti), for dephosphorylating CheY-P. In particular, we identify CheC, known previously to be involved in adaptation to stimuli in Bacillus subtilis, as a CheY-P phosphatase. Using an in vitro assay used previously to demonstrate that the switch protein FliY is a CheY-P phosphatase, we have shown that increasing amounts of CheC accelerate the hydrolysis of CheY-P. In vivo, a double mutant lacking cheC and the region of fliY that encodes the CheY-P binding domain is almost completely smooth swimming, implying that these cells contain very high levels of CheY-P. CheC appears to be primarily involved in restoring normal CheY-P levels following the addition of attractant, whereas FliY seems to act on CheY-P constitutively. The activity of CheC is relatively low compared to that of FliY, but we have shown that the chemotaxis protein CheD enhances the activity of CheC 5-fold. We suggest a model for how FliY, CheC, and CheD work together to regulate CheY-P levels in the bacterium.
Suitability of epitaxial GaAs for x-ray imaging (2004)

Because the rate of indirect photon-electron conversion for scintillator materials coupled with arrays of photodiodes is at least 25 times smaller than the rate of direct conversion, we examine the conditions to be fulfilled by semiconductors undergoing such direct conversion to be applied to x-ray imaging. Bulk grown materials are not well suited to this application, because large defect concentrations give rise to strongly nonuniform electronic properties. We argue that only epitaxial layers are suitable for use as imaging devices and we illustrate our argument using the case of thick epitaxial GaAs layers. Detectors made with such layers exhibit a good energy resolution, a charge collection efficiency which approaches 1, linearity over more than three orders of amplitude, no afterglow (a response time shorter than 20 μs), and no charge-induced polarization effects.
Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers (2015)

Clinically defined AVPC share molecular features with SCPC and are characterized by combined alterations in RB1, Tp53, and/or PTEN.
Symptom Reduction and Suicide Risk in Patients Treated With Placebo in Antidepressant Clinical Trials (2000)

The assumption that depressed patients who are assigned to placebo in antidepressant clinical trials are exposed to substantial morbidity and mortality is not based on research data. We assessed suicides, suicide attempts, and depressive symptom reduction in studies of 7 new antidepressants using the Food and Drug Administration database. Among 19,639 participating patients, 34 committed suicide (0.8% per year), and 130 attempted suicide (2.9% per year). Rates of suicide and attempted suicide did not differ significantly among the placebo- and drug-treated groups. Annual rates of suicide and attempted suicide were 0.4% and 2.7% with placebo, 0.7% and 3.4% with active comparators, and 0.8% and 2.8% with investigational antidepressants, respectively. Symptom reduction was 40.7% with investigational drugs (n = 4,510), 41.7% with active comparators (n = 1,416), and 30.9% with placebo (n = 2,805). These data may help inform discussions about the use of placebo in antidepressant clinical trials.
Could We Spare a Moment of the Spotlight for Persistent, Water-Soluble Polymers? (2019)

RETURN TO ISSUEPREVViewpointNEXTCould We Spare a Moment of the Spotlight for Persistent, Water-Soluble Polymers?Hans Peter H. Arp*Hans Peter H. ArpNorwegian Geotechnical Institute (NGI), P.O. Box 3930 Ullevål Stadion, N-0806 Oslo, NorwayNorwegian University of Science and Technology (NTNU), NO-7491 Trondheim, Norway*Phone: +47 9502 0667; e-mail: [email protected]More by Hans Peter H. Arphttp://orcid.org/0000-0002-0747-8838 and Heidi KnutsenHeidi KnutsenNorwegian Geotechnical Institute (NGI), P.O. Box 3930 Ullevål Stadion, N-0806 Oslo, NorwayMore by Heidi KnutsenCite this: Environ. Sci. Technol. 2020, 54, 1, 3–5Publication Date (Web):December 17, 2019Publication History Received22 November 2019Published online17 December 2019Published inissue 7 January 2020https://doi.org/10.1021/acs.est.9b07089Copyright © 2019 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views4193Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSUBJECTS:Soils,Polyacrylamide,Colloids,Scanning probe microscopy,Polymers Get e-Alerts
Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures (2018)

Imaging analysis of cell morphology is a useful tool for evaluating aging in cell cultures throughout the lifespan of MSCs. Our findings suggest that imaging analysis can reproducibly detect aging-related changes in cell morphology in MSC cultures. These findings suggest that cell morphology is still a supreme measure of cell quality and may be utilized to develop new noninvasive imaging-based methods to screen and quantitate aging in clinical-grade cell cultures.
DUP: Dynamic-Tree Based Update Propagation in Peer-to-Peer Networks (2005)

In peer-to-peer networks, indices are used to map data id to nodes that host the data. The performance of data access can be improved by actively pushing indices to interested nodes. This paper proposes the Dynamic-tree based Update Propagation (DUP) scheme, which builds the update propagation tree to facilitate the propagation of indices. Because the update propagation tree only involves nodes that are essential for update propagation, the overhead of DUP is very small and the query latency is significantly reduced.
A methodological proposal concerning to the management of information security in Industrial Control Systems (2016)

The most recent international reports of security issues documented a growing number of cybernetic attacks to Industrial Control Systems. Therefore, an increase of information technology implementations in manufacturing processes arose offering solutions in Information Security of the involved manufacturers and professionals. In this respect, a notable tendency emerges in which information security has been particularly intended to be used in businesses' administrative areas, where ISO-27000 is the most favored standard. Nonetheless, it has been determined that ISO is not yet an ideal standard for an industrial approach, due to the fact that it has not been created for these systems. We designed and implemented a methodology for the management of information security of the Industrial Control Systems of industrial businesses, based on standards issued by NIST. Such methodology presents the development of a series of phases, which provide two main contributions: firstly a group of strategies to reduce risks and secondly a Guide for standards-based instructions as well as security policies for the effective management of information security.
Lattice-based search strategies for large vocabulary speech recognition (2002)

The design of search algorithms is an important issue in large vocabulary speech recognition, especially as more complex models are developed for improving recognition accuracy. Multi-pass search strategies have been used as a means of applying simple models early on to prune the search space for subsequent passes using more expensive knowledge sources. The pruned search space is typically represented by an N-best sentence list or a word lattice. Here, we investigate three alternatives for lattice search: N-best rescoring, a lattice dynamic programming search algorithm and a lattice local search algorithm. Both the lattice dynamic programming and lattice local search algorithms are shown to achieve comparable performance to the N-best search algorithm while running as much as 10 times faster on a 20 k word lexicon; the local search algorithm has the additional advantage of accommodating sentence-level knowledge sources.
Numerical loss analysis on slot-type casing treatment in a transonic compressor stage (2017)

To understand the loss mechanism of slot-type casing treatment, a numerical loss analysis has been carried out in a 1.5 axial transonic compressor stage with various slots. Spanwise and streamwise distribution curves of pitch-averaged entropy have been presented to survey the development of loss generation. Further, detailed entropy distributions at eight axial cuts, which have been taken through the blade row and slots, have been further analyzed to interpret the loss mechanism. The most dramatic loss growth occurred above 95% span, which directly resulted from slots injection flow upstream the leading edge. Loss generations with smooth casing have been primarily ascribed to low-momentum tip leakage flow/vortex and suction surface separation at the leading edge. CU0 slot, the arc-curved slots with 50% rotor tip exposure, has been capable of suppressing the suction surface separation loss. Meanwhile, accelerated tip leakage flow brought about additional loss near the casing and pressure surface. Upstream high entropy flow would be absorbed into the rear portion of slots repeatedly, which resulted in further loss.
Biochemical and Immunochemical Properties of Modified Human Neuron-Specific Enolase. (1997)

125I-Labeled recombinant human neuron-specific enolase (R-NSE) was inadequate for RIA as a labeled antigen. The binding activity of labeled R-NSE to the antibody was markedly decreased. To supplement this defect and facilitate purification, we constructed two R-NSE derivatives, Y-NSE (one tyrosine residue was added at the N-terminal of R-NSE) and Y-NSE.H6 (six histidine residues were further added at the C-terminal of Y-NSE). The biochemical and immunochemical characteristics of these R-NSE derivatives were essentially the same to those of R-NSE. These derivatives were useful not only as standards for enzyme immunoassay (EIA), but also as labeled antigens for RIA. These results clearly indicate that the reactivity of these modified NSEs to anti-NSE antibody is almost equivalent to that of human brain gammagamma-enolase (B-NSE), and that even if the modified NSEs are labeled, they retain their binding affinities to antibodies in contrast to R-NSE.
Automatic 3D Image Registration for Medical Change Detection Applications (1994)

We are developing an automated 3D change detection system which accurately registers medical imagery (e.g., MRI or CT) of the same patient from different times for diagnosing pathologies, monitoring treatment, and tracking tissue changes. The system employs a combination of energyminimization registration techniques to achieve ac~ curate and robust alignment of 3D data sets. The bases for the registration are 3D surfaces extracted from the 3D imagery. Resultant changes in the data are identified by differencing registered normalized intensity images or comparing measurements of the same segmented tissue over time. The contributions of this work are (1) automation the registration process, (2) high registration accuracy, and (3) registration stability in the presence of noise, outliers, and data deviations. We have applied this system to a rigid registration problem, namely head registration for multiple sclerosis change detection, and are exploring other rigid and flexible registration applications.
Model based hybrid proximity effect correction scheme combining dose modulation and shape adjustments (2011)

The authors present a general approach to combine model-based dose modulations and shape modifications into a hybrid proximity effects correction (PEC) scheme for electron beam lithography. The authors simplify this scheme significantly by using an appropriate dose correction strategy. This allows us to use an existing optical proximity correction tool for the shape adjustments. This hybrid PEC scheme is demonstrated by computing corrections for simple test patterns as well as a more complex pattern. The model used corresponds to an electron multibeam tool with an acceleration voltage of 50 kV. It predicts resist contours from a written dose distribution. The authors evaluate the quality of the results both for nominal process conditions and in the presence of process variations. The results are compared against the corresponding results for a correction using only dose modulation. The authors also use the hybrid scheme to compensate intentional overexposure by shape adjustments and include these results in the comparison so that the impact of overexposure on robustness against process variations can be determined.
Staggered Metallization with Air gaps for Independently Tuned Interconnect Resistance and Capacitance (2020)

An innovative 300mm process architecture that improves interconnect resistance and capacitance is presented. Test structures patterned in novel geometries that lower wiring RC are fabricated, and electrical measurements are compared to simulated values from material and geometrical parameters. Circuit studies with representative examples of such interconnects were performed to quantify the benefit in microprocessor performance and power.
Functional and Structural Features of Cholangiocytes in Health and Disease (2015)

Cholangiocytes are the epithelial cells that line the bile ducts. Along the biliary tree, two different kinds of cholangiocytes exist; small and large cholangiocytes. Each type has important differences in their biological role in physiological and pathological conditions. In response to injury, cholangiocytes become reactive and acquire a neuroendocrine-like phenotype with the secretion of a number of peptides. These molecules act in an autocrine/paracrine fashion to modulate cholangiocyte biology and determine the evolution of biliary damage. The failure of such mechanisms is believed to influence the progression of cholangiopathies, a group of diseases that selectively target biliary cells. Therefore, the understanding of mechanisms regulating cholangiocyte response to injury is expected to foster the development of new therapeutic options to treat biliary diseases. In the present review, we will discuss the most recent findings in the mechanisms driving cholangiocyte adaptation to damage, with particular emphasis on molecular pathways that are susceptible of therapeutic intervention. Morphogenic pathways (Hippo, Notch, Hedgehog), which have been recently shown to regulate biliary ontogenesis and response to injury, will also be reviewed. In addition, the results of ongoing clinical trials evaluating new drugs for the treatment of cholangiopathies will be discussed.
Almost-Binomial Random Variables (2002)

The parameter n in the binomial distribution is a positive integer. What happens if we allow it to be any positive number? The new distribution we get is not only easy to work with but is useful in approximation situations that beginning statistics students could encounter. In addition, applications involving the distribution provide a good source for undergraduate research problems. We begin by setting g(x) = ()pX(l p)n-x, where (n) = n(n-1)(n-x+l) When p < 0.5, we observe that many of the features of the binomial distribution still hold. In particular, -Ex= o g(x) = 1, which follows from the binomial series,
Observer Agreement in the Scoring of the Activity and Chronicity Indexes of Lupus Nephritis (1991)

The present study was designed to evaluate the observer reliability in the scoring of the activity and chronicity indexes, among three experienced pathologists, in renal biopsies from lupus nephritis (LN). Twenty-five renal biopsies of LN, were evaluated independently by three pathologists to assess the interobserver variability. For the intraobserver agreement, 5 biopsies were evaluated twice by each pathologist. The interobserver agreement for the scoring of the activity and chronicity indexes was 0.81 and 0.86, respectively. In the intraobserver agreement the same results were: for the pathologist 1, 0.95 and 0.70; for the pathologist 2, 0.91 and 0.55; for the pathologist 3, 0.89 and 0.82. In conclusion the agreement for the scoring of the activity and chronicity indexes in biopsies from LN was excellent.
Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling (2004)

In the European Organization for Research and Treatment of Cancer (EORTC) classification 2 types of primary cutaneous large B-cell lymphoma (PCLBCL) are distinguished: primary cutaneous follicle center cell lymphomas (PCFCCL) and PCLBCL of the leg (PCLBCL-leg). Distinction between both groups is considered important because of differences in prognosis (5-year survival > 95% and 52%, respectively) and the first choice of treatment (radiotherapy or systemic chemotherapy, respectively), but is not generally accepted. To establish a molecular basis for this subdivision in the EORTC classification, we investigated the gene expression profiles of 21 PCLBCLs by oligonucleotide microarray analysis. Hierarchical clustering based on a B-cell signature (7450 genes) classified PCLBCL into 2 distinct subgroups consisting of, respectively, 8 PCFCCLs and 13 PCLBCLsleg. PCLBCLs-leg showed increased expression of genes associated with cell proliferation; the proto-oncogenes Pim-1, Pim-2, and c-Myc; and the transcription factors Mum1/IRF4 and Oct-2. In the group of PCFCCL high expression of SPINK2 was observed. Further analysis suggested that PCFCCLs and PCLBCLs-leg have expression profiles similar to that of germinal center B-cell-like and activated B-cell-like diffuse large B-cell lymphoma, respectively. The results of this study suggest that different pathogenetic mechanisms are involved in the development of PCFCCLs and PCLBCLs-leg and provide molecular support for the subdivision used in the EORTC classification.
18F-Fluciclovine PET/CT for the Detection of Prostate Cancer Relapse (2015)

In our experimental conditions, (18)F-fluciclovine provided a statistically significant better performance in terms of lesion detection rate as compared with (11)C-choline. However, more studies are required to evaluate the clinical significance of these results in terms of sensitivity, specificity, and accuracy.
Quantitative imaging of gold nanoparticle distribution in a tumor-bearing mouse using benchtop x-ray fluorescence computed tomography (2016)

Abstract X-ray fluorescence computed tomography (XFCT) is a technique that can identify, quantify and locate elements within objects by detecting x-ray fluorescence (characteristic x-rays) stimulated by an excitation source, typically derived from a synchrotron. However, the use of a synchrotron limits practicality and accessibility of XFCT for routine biomedical imaging applications. Therefore, we have developed the ability to perform XFCT on a benchtop setting with ordinary polychromatic x-ray sources. Here, we report our postmortem study that demonstrates the use of benchtop XFCT to accurately image the distribution of gold nanoparticles (GNPs) injected into a tumor-bearing mouse. The distribution of GNPs as determined by benchtop XFCT was validated using inductively coupled plasma mass spectrometry. This investigation shows drastically enhanced sensitivity and specificity of GNP detection and quantification with benchtop XFCT, up to two orders of magnitude better than conventional x-ray CT. The results also reaffirm the unique capabilities of benchtop XFCT for simultaneous determination of the spatial distribution and concentration of nonradioactive metallic probes, such as GNPs, within the context of small animal imaging. Overall, this investigation identifies a clear path toward in vivo molecular imaging using benchtop XFCT techniques in conjunction with GNPs and other metallic probes.