gebhart/patrepeval huggingface dataset:
Ammonia as an Attractive Component of Host Odour for the Yellow Fever Mosquito, Aedes aegypti (1999)

Behavioural responses of Aedes aegypti mosquitoes to ammonia were investigated in a modified Y-tube olfactometer. Ammonia was attractive in concentrations from 17 ppb to 17 ppm in air when presented together with lactic acid. Aqueous solutions of ammonia salts in concentrations comparable to those found in human sweat also increased the attractiveness of lactic acid. The role of lactic acid as an essential synergist for ammonia became further apparent by the fact that ammonia alone or in combination with carbon dioxide was not effective, even though the synergistic effect of carbon dioxide and lactic acid was corroborated. An extract from human skin residues, which attracts approximately 80% of the tested mosquitoes, contains both lactic acid and ammonia. The combination of these compounds, however, attracts no more than 45%, indicating that other components on human skin also play a role in host finding. Preparative liquid chromatography of the skin extract yielded three behaviourally active fractions which work together synergistically. Fraction III contains lactic acid as the effective principle; the compositions of the other two have not been clarified yet. The attractiveness of fraction I was augmented considerably when ammonia was added, whereas the effect of fraction II was not influenced by ammonia. These results suggests that ammonia is part of the effective principle of fraction II and contributes to the attractive effect of host odours.
Reduced Representation Strategies and Their Application to Plant Genomes (2005)

This chapter contains sections titled: Introduction Reduced Representation Techniques EST Sequencing Methylation Filtration Cot-based Cloning and Sequencing De Novo Polymorphism Discovery Reduced Representation Shotgun (RRS) Sequencing DOP-PCR SSR Capture Other Reduced Representation Techniques Discussion Repeat Sequence Enrichment Sequencing Gene space EST Sequencing Methylation Filtration Cot-based Cloning and Sequencing Integration of Reduced Representation Strategies Polymorphism Discovery RRS Sequencing and DOP-PCR Microsatellite Isolation Conclusions Acknowledgments References
Dynamics and nonlinear adaptive control of an autonomous unicycle: theory and experiment (1990)

Equations of motion for an autonomous unicycle are given as derived using Kane's formalism, and the unstable nonminimum-phase behavior of the linearized system is illustrated. Lateral and longitudinal dynamics nominally decouple for low yaw rates but couple nonlinearly for large yaw rates and yaw accelerations. Time scale separation is employed to reduce the model order for inner loop controller design, where an unusual LQG (linear quadratic Gaussian) structure is proposed. Strong dependence of the lateral dynamics on wheel speed necessitates continuous gain scheduling of the lateral controller. A significant nonlinearity exists due to dry friction in yaw between the wheel and floor. Bang-bang control is employed to overcome this. The proposed unicycle has been built and the implemented controller structures and test results are indicated in the paper.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension (2001)

Hyperplasia of pulmonary artery smooth muscle cells (PA-SMCs) is a hallmark pathological feature of primary pulmonary hypertension (PPH). Here we found that PA-SMCs from patients with PPH grow faster than PA-SMCs from controls when stimulated by serotonin or serum and that these effects are due to increased expression of the serotonin transporter (5-HTT), which mediates internalization of indoleamine. In the presence of 5-HTT inhibitors, the growth stimulatory effects of serum and serotonin were markedly reduced and the difference between growth of PA-SMCs from patients and controls was no longer observed. As compared with controls, the expression of 5-HTT was increased in cultured PA-SMCs as well as in platelets and lungs from patients with PPH where it predominated in the media of thickened pulmonary arteries and in onion-bulb lesions. The L-allelic variant of the 5HTT gene promoter, which is associated with 5-HTT overexpression and increased PA-SMC growth, was present in homozygous form in 65% of patients but in only 27% of controls. We conclude that 5-HTT activity plays a key role in the pathogenesis of PA-SMC proliferation in PPH and that a 5HTT polymorphism confers susceptibility to PPH.
An In-Depth Look at Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Clinical Implications from Recent Molecular Findings (2019)

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a highly aggressive cancer in young women. The histogenesis remains unclear although a potential origin of germ cells has been suggested recently. The high throughput next generation sequencing techniques have facilitated the identification of inactivating SMARCA4 mutations as the driver of SCCOHT. These findings may greatly impact on the prevention, diagnosis, molecular classification and treatment of SCCOHTs. The SMARCA4 mutations, typically associated with dual loss of BRG1 and BRM expression, are highly sensitive and specific for the diagnosis of SCCOHT. Germline mutations of SMARCA4 support familial SCCOHT with a critical requirement of genetic counseling and possible prophylactic surgery for carriers. SCCOHT, malignant atypical teratoid/rhabdoid tumors, thoracic sarcomas and some undifferentiated carcinomas harbor rhabdoid morphology and mutations in the SMARC genes, generating an emerging molecular classification of SMARC-mutated tumors. A multi-modality treatment approach consisting of surgery and high dose multi-agent chemotherapy in atypical teratoid/rhabdoid tumors may have potential benefits for SCCOHT patients. Preliminary studies have implicated that the inhibitors targeting EZH2 and the receptor tyrosine kinase, and anti-PD-L1 immunotherapy might be potentially effective for SCCOHT patients. These recent advances on molecular genetics, diagnosis and treatment of SCCOHT address the necessity of multiple institutional collaboration work among oncologist, pathologist, genomic scientist, geneticist, molecular biologist, and pharmacologist.
The enteric nervous system promotes intestinal health by constraining microbiota composition (2017)

Sustaining a balanced intestinal microbial community is critical for maintaining intestinal health and preventing chronic inflammation. The gut is a highly dynamic environment, subject to periodic waves of peristaltic activity. We hypothesized that this dynamic environment is a prerequisite for a balanced microbial community and that the enteric nervous system (ENS), a chief regulator of physiological processes within the gut, profoundly influences gut microbiota composition. We found that zebrafish lacking an ENS due to a mutation in the Hirschsprung disease gene, sox10, develop microbiota-dependent inflammation that is transmissible between hosts. Profiling microbial communities across a spectrum of inflammatory phenotypes revealed that increased levels of inflammation were linked to an overabundance of pro-inflammatory bacterial lineages and a lack of anti-inflammatory bacterial lineages. Moreover, either administering a representative anti-inflammatory strain or restoring ENS function corrected the pathology. Thus, we demonstrate that the ENS modulates gut microbiota community membership to maintain intestinal health.
A novel technique for fabricating high reliable trench dmosfets using self-align technique and hydrogen annealing (2003)

A novel technique for fabricating high reliability trench DMOSFETs using three mask layers is realized to obtain cost-effective production capability, higher cell density and current driving capability, and higher reliability. This technique provides a unit cell with 2.3/spl sim/2.4 /spl mu/m pitch and a channel density of 100 Mcell/in/sup 2/. Specific on-resistance is 0.36 m/spl Omega//spl middot/cm/sup 2/ with a blocking voltage of 43 V at a gate voltage of 10 V and 5 A source-to-drain current. The time to breakdown of gate oxide grown on the hydrogen annealed trench surface is much longer than that of oxide grown on a nonhydrogen annealed trench surface.
Material Characterization by Line-Focus-Beam Acoustic Microscope (1985)

On propose une nouvelle methode de caracterisation tres precise des materiaux. On mesure les caracteristiques de propagation des ondes de fuite a la limite entre l'eau et l'echantillon; la vitesse de phase et l'attenuation sont determinees a travers des mesures de la courbe V(z). On presente une methode d'analyse spectrale pour obtenir les proprietes acoustiques a partir des courbes V(z). Description des mesures effectuees en utilisant des materiaux isotropes ou anisotropes pour lesquels les vitesses s'etendent de 2000 a 11000 m/s. On examine tous les modes d'ondes de fuite impliques dans les phenomenes d'interferences dans les courbes V(z). Resultats experimentaux confirmant les resultats theoriques. Application a l'analyse de la structure des materiaux polycristallins
Induction and activation of tissue transglutaminase during programmed cell death (1987)

During the involution of lead nitrate-induced hyperplasia in rat liver a significant increase of transglutaminase activity, enzyme concentration, transglutaminase messenger RNA and protein-bound epsilon-(gamma-glutamyl)lysine (product of transglutaminase action) coincided with programmed death (apoptosis) of hepatocytes. Immunohistochemical examination showed the appearance of transglutaminase in apoptotic hepatocytes. An increased transglutaminase level was also detected during glucocorticoid-induced apoptosis of rat thymocytes.
Heart transplantation in an 8-month-old girl. 10th anniversary report. (1995)

In 1984, Dr. Denton A. Cooley led a surgical team that implanted a cardiac allograft in an 8-month-old girl who had end-stage cardiac disease secondary to endocardial fibroelastosis. At that time, experience with cardiac transplantation in infants was limited, and the long-term effects of the procedure were cause for concern. Ten years later, our patient is a healthy 4th-grade student who enjoys a remarkably normal life. She has grown and developed quite satisfactorily, and her heart has enlarged in proportion to her overall somatic growth. Long-term immunosuppression has produced no adverse effects, and the child's medical problems have differed little from those of her peers. This landmark case has yielded preliminary answers to a number of important questions about cardiac transplantation in infants and has confirmed our original opinion that the procedure is well warranted in selected patients.
The standardized 12-lead fetal electrocardiogram of the healthy fetus in mid-pregnancy: A cross-sectional study (2020)

We have presented a method for estimating a standardized 12-lead fetal ECG. In mid-pregnancy, the median electrical heart axis is right inferiorly oriented in healthy fetuses. Future research should focus on fetuses with congenital heart disease.
Dynamic precipitation during multi-axial forging of an Mg–7Gd–5Y–1Nd–0.5Zr alloy (2013)

The dynamic precipitation behavior during multi-axial forging in an Mg–7Gd–5Y–1Nd–0.5Zr alloy has been investigated and compared with that in static precipitation treatment. The results indicated that dynamic precipitation does occur during multi-axial forging. The dynamic precipitate can be deduced as β phase with face-centered cubic crystal structure (a = 2.22 nm). Most of the β precipitates locate at the dynamic recrystallization grain boundaries. The morphology and orientation relationship is different from that of the β phase formed in the static precipitation treated alloys, although the crystal structure is the same. The precipitation temperature of β phase during MAF is higher than that in the static precipitation treatment.
Capping with Multivalent Surfactants for Zeolite Nanocrystal Synthesis (2013)

Multiammonium surfactants exhibited a remarkable capping effect for zeolite synthesis in the forms of nanoparticles, nanorods, and nanosponges in cases where common monovalent surfactants failed. A nanorod-shaped mordenite zeolite synthesized in this manner showed significantly enhanced catalytic lifetimes in acid-catalyzed cumene synthesis reactions.
Pharmacokinetics of Nitroxide NMR Contrast Agents (1984)

Pharmacokinetics of the nitroxide stable free radical functionality of compounds containing this moiety were evaluated in the rat. The agents were injected i.v. at either high (1.75 mmoles/kg) or low (10 mumoles/kg) dose, and timed blood samples were drawn and assayed for nitroxide concentration by EPR spectrometry. Similarly, various organs and tissues were removed at specified times after injection and homogenized for determination of nitroxide concentration. Urine was collected by catheter for estimation of urinary excretion of the intact nitroxide free radical. At high doses, the various nitroxides exhibited an initial rapid disposition phase, followed by a terminal disposition phase with disappearance from the blood showing apparent log-linear half-lives of about 5 to 30 minutes. Generally, 20 to 60% of the dose was recovered in the urine. At low doses, dissimilar results were obtained. Blood levels again showed biphasic decay; however, blood concentrations at all times were much lower than those predicted by the high dose kinetics, indicating probably nonlinear pharmacokinetic behavior. Tissue homogenate studies showed low or nondetectable levels of nitroxide signal, demonstrating that the low blood concentrations could not be accounted for by a rapid uptake into specific tissues. Moreover, only 2 to 6% of the nitroxide could be recovered in the urine. Additional studies demonstrated that at the low dose a rapid in vivo bioreduction occurred which appeared to be saturable at the higher dose.
Silicon microstructures and microactuators for compact computer disk drives (1994)

Advances in VLSI and software technology have been the primary engines for the ongoing information revolution. But the steady stream of technical innovations in magnetic disk recording technology are also important factors contributing to the economic strengths of the computer and information industry. One important technology trend for the disk drive industry has been that of miniaturization. As this trend continues, future disk drives will have the same form factor as VLSIs, storing gigabytes of data. Silicon micromachining technology will play an important role in the fabrication of high-bandwidth servo-controlled microelectromechanical components for future super-compact disk drives. At UCLA and Caltech, for the past two years (1992-94) we have initiated a number of industry-supported joint research projects to develop microstructures and microactuators for future generation super compact magnetic recording rigid disk drives, including one to design and fabricate silicon read/write head microsuspensions with integrated electrical and mechanical interconnects, which target the next generation 30% form factor pico-sliders, and one for electromagnetic piggyback microactuators in super high-track-density applications, both of which utilize state-of-the-art silicon micromachining fabrication techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modeling, design and characterization of a new low jitter analog dual tuning LC-VCO PLL architecture (2004)

This paper describes the modeling, design and characterization of a low jitter 2.4 GHz LC-VCO PLL architecture realized in a standard 0.12 /spl mu/m CMOS technology. It features very low VCO gain for noise rejection and it is equipped with an automatic analog calibration of the VCO curve. Measurements show the integrated jitter to be 0.74 ps, that is 43% lower with respect to a standard PLL topology which has same bandwidth and same output frequency range, build for comparison on the same wafer. The circuit area is 0.7 mm/sup 2/ (less then 1% larger than the reference PLL) and the power consumption is 32 mW (1% higher).
Continuous inference of psychological stress from sensory measurements collected in the natural environment (2011)

Repeated exposures to psychological stress can lead to or worsen diseases of slow accumulation such as heart diseases and cancer. The main challenge in addressing the growing epidemic of stress is a lack of robust methods to measure a person's exposure to stress in the natural environment. Periodic self-reports collect only subjective aspects, often miss stress episodes, and impose significant burden on subjects. Physiological sensors provide objective and continuous measures of stress response, but exhibit wide between-person differences and are easily confounded by daily activities (e.g., speaking, physical movements, coffee intake, etc.). In this paper, we propose, train, and test two models for continuous prediction of stress from physiological measurements captured by unobtrusive, wearable sensors. The first model is a physiological classifier that predicts whether changes in physiology represent stress. Since the effect of stress may persist in the mind longer than its acute effect on physiology, we propose a perceived stress model to predict perception of stress. It uses the output of the physiological classifier to model the accumulation and gradual decay of stress in the mind. To account for wide between-person differences, both models self-calibrate to each subject. Both models were trained using data collected from 21 subjects in a lab study, where they were exposed to cognitive, physical, and social stressors representative of that experienced in the natural environment. Our physiological classifier achieves 90% accuracy and our perceived stress model achieves a median correlation of 0.72 with self-reported rating. We also evaluate the perceived stress model on data collected from 17 participants in a two-day field study, and find that the average rating of stress obtained from our model has a correlation of 0.71 with that obtained from periodic self-reports.
<title>Deposition of thin polymer films by pulsed excimer laser ablation</title> (1995)

Deposition of thin Polytetrafluorethylene (PTFE) film by laser ablation deposition (LAD) technique is briefly described. The method utilization, transport conditions, and optimal setup are presented. The paper also deals with the methods of prepared thin films characterization (scanning electron microscopy, x-ray diffraction, and Fourier transform infrared spectroscopy) and comments on all data achieved from all characterization measurements.
Sirolimus-eluting cobalt-chromium stents: two-year clinical results from first-in-man study on the Firebird 2 stent. (2008)

Compared with the bare cobalt alloy stent, the Firebird 2 sirolimus-eluting cobalt-chromium stent is safe and effective in treating patients with CAD. The use of this stent was associated with a sustained clinical benefit and significantly lower rate of TLR and MACE up to 2 years post-stenting.
Design reuse in hypermedia applications development (1997)

Article Free Access Share on Design reuse in hypermedia applications development Authors: Gustavo Rossi LIFIA, Fac. Cs. Exactas, UNLP, Argentina and CONICET LIFIA, Fac. Cs. Exactas, UNLP, Argentina and CONICETView Profile , Daniel Schwabe Departamento de Informática, PUC-RIO, Brazil Departamento de Informática, PUC-RIO, BrazilView Profile , Alejandra Garrido LIFIA, Fac. Cs. Exactas, UNLP, Argentina LIFIA, Fac. Cs. Exactas, UNLP, ArgentinaView Profile Authors Info & Claims HYPERTEXT '97: Proceedings of the eighth ACM conference on HypertextApril 1997 Pages 57–66https://doi.org/10.1145/267437.267444Published:15 April 1997Publication History 59citation718DownloadsMetricsTotal Citations59Total Downloads718Last 12 Months33Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Proline‐Catalyzed Asymmetric α‐Amination of Aldehydes and Ketones—An Astonishingly Simple Access to Optically Active α‐Hydrazino Carbonyl Compounds (2003)

Simple, direct, and highly enantioselective α-amination of carbonyl compounds 1 with azodicarboxylates 2 no longer requires prior enolization of the substrate. The “magic” small-organic-molecule catalyst for this reaction in dichloromethane at room temperature is once again L-proline (3).
Continuously Tunable, Polarization Controlled, Colour Palette Produced from Nanoscale Plasmonic Pixels (2016)

Colour filters based on nano-apertures in thin metallic films have been widely studied due to their extraordinary optical transmission and small size. These properties make them prime candidates for use in high-resolution colour displays and high accuracy bio-sensors. The inclusion of polarization sensitive plasmonic features in such devices allow additional control over the electromagnetic field distribution, critical for investigations of polarization induced phenomena. Here we demonstrate that cross-shaped nano-apertures can be used for polarization controlled color tuning in the visible range and apply fundamental theoretical models to interpret key features of the transmitted spectrum. Full color transmission was achieved by fine-tuning the periodicity of the apertures, whilst keeping the geometry of individual apertures constant. We demonstrate this effect for both transverse electric and magnetic fields. Furthermore we have been able to demonstrate the same polarization sensitivity even for nano-size, sub-wavelength sets of arrays, which is paramount for ultra-high resolution compact colour displays.
Metabolism of [<sup>1</sup><sup>4</sup>C]Prometryn in Rats (1999)

[(1)(4)C]Prometryn, 2, 4-bis(isopropylamino)-6-(methylthio)-s-triazine, was orally administered to male and female rats at approximately 0.5 and 500 mg/kg; daily urine and feces were collected. After 3 or 7 days rats were sacrificed, and blood and selected tissues were isolated. The urine and feces extracts were characterized for metabolite similarity as well as for metabolite identification. Over 30 metabolites were observed, and of these, 28 were identified mostly by mass spectrometry and/or cochromatography with available reference standards. The metabolism of prometryn was shown to occur by N-demethylation, S-oxidation, S-S dimerization, OH substitution for NH(2) and SCH(3), and conjugation with glutathione or glucuronic acid. Rat liver microsomal incubations of prometryn were conducted and compared to the in vivo metabolism. Both in vivo and in vitro phase I metabolisms of prometryn were similar, with S-oxidation and N-dealkylation predominating. The involvement of cytochrome P-450 and flavin-containing monooxidase in the in vitro metabolism of prometryn was investigated.