gebhart/patrepeval huggingface dataset:
Association of autologous AdHER2 dendritic cell vaccination with antitumor activity and number of circulating tumor cells. (2017)

3089 Background: We achieved cure of large established tumors in syngeneic BALB/c mice using an adenoviral vector vaccine expressing rodent HER2 extracellular (EC) and transmembrane (TM) domains mediated by the induction of anti-HER2 antibodies. We report clinical translation utilizing an autologous adenoviral- transduced dendritic cell (DC) vaccine expressing human HER2 EC and TM domains (AdHER2ECTM) in adults with advanced metastatic tumors with 1-3+ HER2 expression. Methods: In this two-part phase I study (NCT01730118) subjects with HER2+ metastatic solid tumors naïve to HER2-targeted therapies (Part 1) or HER2+ treatment-experienced breast cancer (Part 2) received 5 doses of vaccine at Weeks 0, 4, 8, 16 and 24. Part 1 dose escalation involved 3 cohorts of 6 patients utilizing 5x10 6 , 10x10 6 and 20x10 6 viable DCs per dose, respectively. With no DLTs or evidence of cardiac toxicity, dose escalation to 40x10 6 viable DCs per dose was allowed in the Part 1 Expansion Cohort and Part 2 treatment was begun at a starting dose of 20x10 6 viable DCs per vaccine. Adjuvant muscle-invasive bladder cancer patients were allowed to enroll with safety documented out to 12 weeks in > 10 treated patients. Re-staging was assessed using immune-related response criteria (irRC). Remaining study accrual: Part 1 (N = 9), Part 2 (N = 24). Results: A total of 27 cancer patients (7 colon, 6 breast, 5 ovarian, 3 bladder, 6 other) have received > 2 vaccine doses (median 4): 19F, 8M, median age 60 yrs, median 3 prior treatment regimens (range 1-11); HER2 IHC 1+ N = 6, 2+ N = 9, 3+ N = 12. Of metastatic patients receiving 10x10 6 viable DCs per dose or higher, 7 of 19 (37%) had evidence of response by irRC: 1 CR (ongoing at 100 weeks), 1 PR (-71% lasting 44 weeks) and 5 SD (median duration 24 weeks, range 8 to 48 weeks). Two adjuvant bladder cancer patients remain without disease at 100 weeks. Adverse events were limited to local injection site reactions < G2. Of patients with paired baseline samples, 40% (8/20), 83% (5/6) and 100% (2/2) exhibited decreases in circulating tumor cells at 12, 28 and 48 weeks, respectively. Conclusions: AdHER2 DC vaccination is safe and is associated with evidence of clinical benefit and anti-tumor activity. Clinical trial information: NCT01730118.
Coordinated linear beamforming in downlink multi-cell wireless networks (2008)

We consider the problem of co-channel interference mitigation in a downlink multi-cell wireless network. Assuming that each access point serves multiple single-antenna mobiles via space division multiple access (SDMA), we jointly optimize the linear beam-vectors across a set of coordinated cells and resource slots: the objective function to be maximized is the weighted system sum-rate subject to per-base-station power constraints. After deriving the general structure of the optimal beam-vectors, a novel iterative algorithm is presented which attempts to solve the Karush-Kuhn-Tucker (KKT) conditions of the non-convex primal problem at hand. Simulation results are provided to assess the performance of the proposed algorithm.
Dynamic accommodation measurements for objective assessment of eyestrain and visual fatigue. (1988)

A high-precision optometer system has been developed for dynamic measurement of the refractive power of the eye. With the use of individually chosen stimulus steps, a subject's accommodation performance can be unobtrusively assessed in about 3 min. The area under the plotted response curve is used as an integrated measure of dynamic accommodation performance
The role of the surface in transient enhanced diffusion (1995)

The enhanced diffusion of impurities that is seen following ion implantation is rapidly quenched, hence, the name transient enhanced diffusion (TED). The quenching of TED is associated with the annealing of implant damage, either by the diffusion of point defects to the bulk or to the surface. It is variously assumed that either the surface or the bulk is the predominant annealing site. In this work, we explore these assumptions by observing the reduction of TED in a buried marker, when the surface is etched to bring it closer to implanted damage. The results show a considerable reduction in TED with surface etching, demonstrating that the surface plays a key role in annealing implant damage. Numerical modeling allows extraction of the surface recombination length of interstitials at 800 °C. Only a value of 0.1 μm is consistent with the data. All but a very small fraction of implanted interstitials are recombined at the surface with this value.
Optimized Design Method for Heterogeneous Trench-assisted Multi-core Fiber (2013)

By designing the cores, trench layers and core number, we propose a relative optimized design scheme for heterogeneous trench-assisted multi-core fiber (Hetero-TA-MCF), which is a bend-insensitive MCF with high density of cores and ultra-low crosstalk.
Co-Channel Interference Cancellation in Cellular OFDM Networks - PART I : Maximum-Likelihood Co-Channel Interference Cancellation with Power Control for Cellular OFDM Networks (2007)

In cellular orthogonal frequency division multiplexing (OFDM) networks, co-channel interference (CCI) leads to severe degradation in the BER performance. To solve this problem, maximum-likelihood estimation (MLE) CCI cancellation scheme has been proposed in the literature. MLE CCI cancellation scheme generates weighted replicas of the transmitted signals where weights represent the estimated channel transfer functions. The replica with the smallest Euclidean distance from the received signal is selected and data are detected. When the received power of the desired and interference signals are nearly the same, the BER performance is degraded. In this paper, we propose a closed-loop power control (PC) scheme capable of detecting the equal received power situation at the mobile station (MS) receiver by using the newly introduced parameter power ratio (PR). When this situation is detected, the MS sends a feedback to the desired base station (BS) which boosts the transmission power in the next frame. At cell edge where signal to interferer ratio (SIR) is considered to have average value between -5 dB and 10 dB, computer simulations show that the proposed CCI cancellation scheme has a gain of 7 dB at 28 Km/h.
Internal temperature measurements in response to cryogen spray cooling of a skin phantom (1999)

Cryogen spray cooling (CSC) can protect the epidermis from non-specific thermal injury during laser treatment of port wine stains and other hypervascular cutaneous malformations. Knowledge of skin internal temperatures in response to CSC is essential for optimization of this technique. We used an epoxy resin compound to construct a kind phantom and measured its internal temperatures in response to cooling with different cryogens at various spurt durations, spraying distances, and ambient humidity levels. The measured temperature distributions during CSC were fitted by a mathematical model based on thermal diffusion theory. For spurt durations up to 100 ms, temperature reduction within the phantom remained confined to the upper 200 μm, and was affected by spraying distance. Depending on the cryogen used, temperature reductions up to 45°C could be measured 20 μm below the surface at the end of a 100 ms spurt. However, the cryogen film temperature on the epoxy resin surface was up to 35°C lower, indicating lack of perfect thermal contact at the cryogen film-phantom interface. Theoretical predictions were within 10% of measured temperatures. Ice formation occurred following termination of the spurt and was influenced by the ambient humidity level.
Time reversal data communications on pipes using guided elastic waves: Part II. Experimental studies (2011)

Embedded sensors in large civil structures for structural health monitoring applications require data communication capabilities between sensor nodes. Conventional communication modalities include electromagnetic waves or acoustical waves. However, ultrasonic guided elastic waves that can propagate on solid structures such as pipes for a great distance have rarely been studied for data communication purposes. The multi-modal and dispersive characteristics of guided waves make it difficult to interpret the channel responses and to transfer useful information along pipes. Time reversal is an adaptive transmission method that can improve the spatial and temporal wave focusing. Based on the focusing effect of time reversal, we have developed a data communication technique using guided waves in a highly dispersive pipe environment. In this paper, we experimentally demonstrate the data communication using time reversal pulse position modulation (TR-PPM). Three-step laboratory tests have been performed using piezoelectric transducers in a pitch-catch mode. We first measure the channel responses between the transmitter and the receiver on a pipe. We then carry out the time reversal transmission by reversing the sounding signal and feeding it back to the same channel. Finally, we perform the time reversal communication experiment by sending the modulated time reversal signals as a stream of binary bits at a given data rate. A series of experiments are conducted on steel pipes. Experimental results demonstrate that time reversal pulse position modulation for data communications can be achieved successfully using guided elastic waves.
Reduction of Proximity Effects on UHF Passive RFID Systems by Using Tags With Polarization Diversity (2015)

A new technique that enables passive ultra high frequency (UHF) radio frequency identification (RFID) tags to be read when they are placed in close proximity in an array is presented. This paper demonstrates that, in a linear tag array with a tag separation of 1 cm, the interaction between the backscattered waves and incident wave causes a significant degradation in tag sensitivity. It is found that the use of tags that have polarization diversity can improve the read performance when they are placed in close proximity to one another compared with conventional linear tags. Two ways of achieving polarization diversity are studied in this paper, namely: 1) using a circularly polarized tag and 2) using a cross-polarized tag pair. Both methods show an improvement in close proximity read performance and it is experimentally demonstrated that by using cross-polarized tag pairs in an array, one achieves on average a 2.6-dB increase in read power margin for a 57-tag array with 1 cm separation compared with using conventional linearly polarized tags.
B-mode blood flow (B-Flow) imaging (2001)

B-Flow is a new technique that extends the resolution, frame rate, and dynamic range of B-mode to simultaneously image blood flow and tissue. B-Flow relies on coded excitation to boost weak signals from blood scatterers and on tissue equalization to simultaneously display flowing blood and tissue without threshold decision and overlay. Various classes of codes such as Barker and Golay may be used. Clinical B-Flow cineloops demonstrate 3× resolution and frame rate improvement over color flow, which, together with over 60 dB of display dynamic range, is able to image hemodynamics and vessel walls with unprecedented clarity.
Social ties and their relevance to churn in mobile telecom networks (2008)

Social Network Analysis has emerged as a key paradigm in modern sociology, technology, and information sciences. The paradigm stems from the view that the attributes of an individual in a network are less important than their ties (relationships) with other individuals in the network. Exploring the nature and strength of these ties can help understand the structure and dynamics of social networks and explain real-world phenomena, ranging from organizational efficiency to the spread of information and disease.
Traumatic Pelvic Injury Outcome Prediction by Extracting Features from Relevant Medical Records and X-Ray Images (2009)

Traumatic pelvic injuries are complex and difficult to treat, due to the high risk of complications. Prompt and accurate medical treatment is therefore vital. Computer-aided decision-making systems can assist physicians in this task, but none of those proposed so far incorporate features extracted from medical images. The study in this paper uses demographic information, standard medical measurements, and features extracted from X-ray images to predict a patient's length of stay in ICU via rules extracted from decision trees generated by the CART algorithm. The X-ray features are extracted by using a spline/ASM segmentation technique to detect structure position, then calculating measures of displacement. The results are promising and compare well with SVM and C4.5 algorithms, indicating that the rules represent true data patterns. Significantly, an X-ray feature is selected as highly important to injury severity, indicating that medical image features are important in providing accurate recommendations and predictions.
Independent detection of vertical and lateral forces with a sidewall-implanted dual-axis piezoresistive cantilever (1998)

A dual-axis atomic force microscope (AFM) cantilever with independent piezoresistive sensors has been developed for simultaneous detection of vertical and lateral forces. The cantilever consists of a flat, triangular probe connected to a base by four tall, narrow ribs. The vertically compliant triangular probe and the laterally compliant ribs incorporate separate piezoresistors for vertical and lateral force sensing. In the fabrication process, a special oblique ion implant technique is used to produce electrical elements on vertical sidewalls and horizontal surfaces of the cantilever structure at the same time. The dual-axis cantilever has been used to perform microfriction measurements as well as obtain simultaneous vertical-force and lateral-force AFM images.
First Arrival Picking of Seismic Data Based on Trace Envelope (2019)

We introduce a new method for first arrival traveltime picking based on the maximum difference between adjacent points of the envelope (MDPE) of a seismic trace. The method starts by calculating the Hilbert transform of the seismic trace to generate the complex seismic trace, which consists of the real and imaginary parts of a seismic trace. After generating the complex seismic trace, the instantaneous amplitude or envelope is extracted and used to pick the first arrival traveltime. We test the proposed method on synthetic shot records. When we compared the automatically picked first arrival traveltimes using our proposed method versus those picked manually by an experienced processor, we found that our proposed method estimated the first arrival traveltimes with more than 88% picking accuracy (within 0.1 s of manual picks). Furthermore, we perform the same test on real shot records and the proposed method estimated the first arrival traveltimes with a picking accuracy of 85% (within 0.1 s of manual picks). Finally, we apply the proposed method on 58 traces extracted from a real 2D land seismic data set from southeast Texas on which first arrival traveltime was difficult to pick automatically. We compare our proposed method and the P-phase picker method against manual picks. Results show that the proposed method has a picking accuracy of 99%, while the P-phase picker method gives 83% picking accuracy (within 0.1 s of manual picks).
Validation of Retinal Image Registration Algorithms by a Projective Imaging Distortion Model (2007)

Fundus camera imaging of the retina is widely used to document ophthalmologic disorders including diabetic retinopathy, glaucoma, and age-related macular degeneration. The retinal images typically have a limited field of view due mainly to the curvedness of human retina, so multiple images are to be joined together using image registration technique to form a montage with a larger field of view. A variety of methods for retinal image registration have been proposed, but evaluating such methods objectively is difficult due to the lack of a reference standard for the true alignment of the individual images that make up the montage. A method of generating simulated retinal image set by modeling geometric distortions due to the eye geometry and the image acquisition process is described in this paper. We also present the validation tool for any retinal image registration method by tracing back the distortion path and accessing the geometric misalignment from the coordinate system of reference standard. The quantitative comparison for different registration methods is given in the experiment, so the registration performance is evaluated in an objective manner.
Horizontal and Slant-Path Surveillance with Speckle Imaging (2002)

A fundamental problem in providing high-quality surveillance images recorded over long horizontal or slant paths is the blurring caused by atmospheric turbulence, which reduces both the resolution and contrast. The objective of the work reported here is to develop a capability for long-range imaging through the atmosphere that is not limited by the atmosphere but only by the fundamental diffraction limit of the optics. This paper describes our recent horizontal and slant-path imaging experiments of point targets and extended scenes as well as simulations of point targets in comparison to experiment. We show the near-diffraction limited resolution results obtained using bispectral speckle-imaging techniques. The experiments were performed with an 8-inch diameter telescope placed either in a field, on a rooftop, or on a hillside and cover ranges of interest from 100 meters up to 10 km. The scenery includes resolution targets, people, vehicles, and other structures.
A simple high capacity multiple service solution with controlled QoS for GERAN (2003)

Offering multiple services with high spectral efficiency is crucial for 3rd generation cellular systems. Further, for stable system behavior, controlling quality of service (QoS) for offered loads beyond the capacity limit of the systems is required. This paper describes and evaluates a simple, easy-to-plan concept that accomplishes this goal for the GSM/EDGE Radio Access Network (GERAN). Cornerstones of the concept are tight frequency reuse, service-based power setting and power-based admission control. Preliminary results indicate that the proposed solution manages to preserve targeted QoS for a mix of services at excessive traffic loads. Moreover, different operator QoS policies may be realized in a straightforward manner.
Managing the Dynamics of a Harmonic Potential Field-Guided Robot in a Cluttered Environment (2008)

This paper demonstrates the ability of the harmonic potential field (HPF) planning method to generate a well-behaved constrained path for a robot with second order dynamics in a cluttered environment. It is shown that HPF-based controllers may be developed for holonomic, as well as nonholonomic, robots to effectively suppress the effect of inertial forces on the robot's trajectory while maintaining all the attractive features of a purely kinematic HPF planner. The capabilities of the suggested navigation controller are demonstrated using simulation results for the holonomic and nonholonomic cases.
Real-time measurement of ultrashort optical pulses using SPIDER (2003)

Summary form only given. Real-time characterization of ultrashort optical pulses is critical for a number of important emerging applications: adaptive phase control for oscillator and amplifier optimization, quantum control with learning feedback, laser diagnostics, nonlinear pulse propagation and ultrafast spectroscopy. To date, however, most techniques that return quantitative, high resolution information about the pulse shapes do so at a sub-Hertz repetition rate. It is possible to increase the acquisition rate in certain cases by using a reduced resolution spectrogram and dedicated signal processing hardware, as has been demonstrated by Kane (1998). We present a real-time pulse measurement-device that has no moving components, requires only one-dimensional data collection, and uses a noniterative inversion algorithm. Our technique, spectral phase interferometry for direct electric-field reconstruction (SPIDER), retrieves the spectral phase of the input pulses at an update rate of greater than 15 Hz using an inexpensive linear CCD array and standard data acquisition hardware in a desktop computer that implements the simple and rapid inversion algorithm in LabView.
Production of high-brightness CW proton beams with very high proton fractions (1995)

This paper demonstrates a new technique to significantly enhance the proton fraction of an ion beam extracted from a plasma ion source. We employ a magnetically confined microwave driven source, though the technique is not source-specific and can probably be applied equally effectively to other plasma sources such as Penning and multicusp types. Specifically, we dope the plasma with about 1% H{sub 2}O, which increases the proton fraction of a 45 keV 45 mA beam from 75 to 90% with 375W 2.45 GHz power to the source and from 84% to 92% for 500W when the source is operated under nonresonant conditions. Much of the remaining fraction of the beam comprises a heavy mass ion we believe to be N{sup +} impurity ions resulting from the conditions under which the experiments were performed. If so, this impurity can be easily removed and much higher proton fractions could be expected. Preliminary measurements show the additive has no adverse effect on the emittance of the extracted beam, and source stability is greatly improved.
Automated red blood cell differential analysis on a multi‐angle light scatter/fluorescence hematology analyzer (2003)

The 3D RBC cytograms provide a wealth of morphologic information useful for diagnosis and treatment of patients. With powerful computer programs available today, it is evident that the rate of smear review can be significantly reduced as a result.
ProAlignNet : Unsupervised Learning for Progressively Aligning Noisy\n Contours (2020)

Contour shape alignment is a fundamental but challenging problem in computer\nvision, especially when the observations are partial, noisy, and largely\nmisaligned. Recent ConvNet-based architectures that were proposed to align\nimage structures tend to fail with contour representation of shapes, mostly due\nto the use of proximity-insensitive pixel-wise similarity measures as loss\nfunctions in their training processes. This work presents a novel ConvNet,\n"ProAlignNet" that accounts for large scale misalignments and complex\ntransformations between the contour shapes. It infers the warp parameters in a\nmulti-scale fashion with progressively increasing complex transformations over\nincreasing scales. It learns --without supervision-- to align contours,\nagnostic to noise and missing parts, by training with a novel loss function\nwhich is derived an upperbound of a proximity-sensitive and local\nshape-dependent similarity metric that uses classical Morphological Chamfer\nDistance Transform. We evaluate the reliability of these proposals on a\nsimulated MNIST noisy contours dataset via some basic sanity check experiments.\nNext, we demonstrate the effectiveness of the proposed models in two real-world\napplications of (i) aligning geo-parcel data to aerial image maps and (ii)\nrefining coarsely annotated segmentation labels. In both applications, the\nproposed models consistently perform superior to state-of-the-art methods.\n