gebhart/patrepeval huggingface dataset:
Spectrum monitoring scheme for filter bank based cognitive radios (2010)

This paper focuses on the spectrum monitoring problem, i.e., detecting reappearing primary users during secondary transmissions in cognitive radio systems. The filter bank multicarrier (FBMC) concept is used as the basis as it facilitates simultaneous spectrum sensing and reception of secondary transmissions using the same device. With FBMC it is possible to support, in a spectrally efficient manner, narrow subcarrier-wide gaps in the spectrum of the transmitted signal for monitoring purposes. Such scheme allows fast reaction to reappearing primary users and it needs minimum amount of coordination between independent secondary systems operating in the same frequency band. We analyze the effect of the filter bank frequency response on energy detection based spectrum sensing. We also evaluate the impact of spectral regrowth due to transmitter power amplifiers, which is a critical issue in the proposed scheme.1
Assessing the risks and opportunities of Cloud Computing &#x2014; Defining identity management systems and maturity models (2010)

Despite the potential that Cloud Computing has for revolutionizing every aspect of the software industry, there are significant shortcomings in the area of security and risk assessment and mitigation. The basic value proposition of Cloud Computing is that by leasing applications online, companies have the potential to significantly reduce their operating costs. What is not often pointed out however is the fact that identity management on Cloud Computing platforms is still in its nascent or very embryonic stages. Often identity management systems fail to fully protect all assets of a given Cloud Computing platform as role-based access has yet to be defined and implemented. Lacking is a protocol stack of Cloud Computing Identity Management and a maturity model to assist organizations in assessing their relative levels of risk. The intent of this analysis is to provide the frameworks for both the protocol stack and maturity model for Cloud Computing platforms.
Hospitalizations for Endemic Mycoses: A Population-Based National Study (2006)

We performed a retrospective cohort study, using the 2002 Nationwide Inpatient Sample, a national database of hospital inpatient stays, to describe the incidence and epidemiology of endemic mycoses requiring hospitalization. An estimated 332 pediatric and 6003 adult patients with endemic mycoses required hospitalization (4.6 and 28.7 cases per 1 million children and adults, respectively). Crude mortality rates were 5% and 7% among children and adults, respectively.
Persistent HPV infection in postmenopausal age women (2004)

Postmenopausal women are infected with persistent oncogenic HPV at a substantial rate, supporting the need for continued screening in postmenopausal women to detect preneoplastic genital lesions.
Color and Chemical Stability of a Variety of Anthocyanins and Ascorbic Acid in Solution and Powder Forms (2013)

The color and chemical stabilities of six anthocyanins, including cyanidin 3-glucoside, highly purified and present in semipurified extracts (also containing other anthocyanins) from grape pomace, purple corn, and black rice, were determined in combination with ascorbic acid in solutions at differing pH values (3.0 and 4.0) and temperatures (6-40 °C) and lyophilized powders at different relative humidities (43-98% RH). Color and chemical changes were analyzed using CIELAB measurements and HPLC, respectively. In liquids, stability was inversely related to increasing pH and temperature; for powders, stability was inversely related to RH. The mutual destruction of anthocyanins and ascorbic acid in solution was confirmed, with unexpected new findings showing no significant stabilizing/destabilizing effect based upon anthocyanin structure, including differing flavylium core (three types) and type of acylation (two aliphatic, one cinnamic acid), or final extract purity.
Prospects for mucosal vaccine: shutting the door on SARS-CoV-2 (2020)

The sudden emergence of a highly transmissible and pathogenic coronavirus SARS-CoV-2 in December 2019 from China and its rapid global spread has posed an international health emergency. The rapid development of an effective vaccine is imperative to control the spread of SARS-CoV-2. A number of concurrent efforts to find an effective therapeutic agent or vaccine for COVID-19 (coronavirus disease 2019) are being undertaken globally. Oral and nasal mucosal surfaces serve as the primary portal of entry for pathogens like coronaviruses in the human body. As evidenced by studies on similar coronaviruses (SARS-CoV and MERS-CoV), mucosal vaccination can provide a safe and effective means for the induction of long-lasting systemic and mucosal immunity to confer protection against SARS-CoV-2. This article summarizes the approaches to an effective mucosal vaccine formulation which can be a rewarding approach to combat the unprecedented threat posed by this emerging global pandemic.
A characteristic biosignature for discrimination of gastric cancer from healthy population by high throughput GC-MS analysis (2016)

Early diagnosis of gastric cancer is crucial to improve patient' outcome. A good biomarker will function in early diagnosis for gastric cancer. In order to find practical and cost-effective biomarkers, we used gas chromatography combined mass spectrometer (GC-MS) to profile urinary metabolites on 293 urine samples. Ninety-four samples are taken as training set, others for validating study. Orthogonal partial least squares discriminant analysis (OPLS-DA), significance analysis of microarray (SAM) and Mann-Whitney U test are used for data analysis. The diagnostic value of urinary metabolites was evaluated by ROC curve. As results, Seventeen metabolites are significantly different between patients and healthy controls in training set. Among them, 14 metabolites show diagnostic value better than classic blood biomarkers by quantitative assay on validation set. Ten of them are amino acids and four are organic metabolites. Importantly, proline, p-cresol and 4-hydroxybenzoic acid disclose outcome-prediction value by means of survival analysis. Therefore, the examination of urinary metabolites is a promising noninvasive strategy for gastric cancer screening.
Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites (2017)

εPKC phosphorylation and its coevolution with ALDH2 play an important role in the regulation and protection of ALDH2 enzyme activity.
SPECIES DIVERSITY GRADIENT TO DARKNESS STRESS IN BLUE-GREEN ALGAE/CYANOBACTERIA: A MICROSCALE TEST IN A PREHISTORIC CAVE, MOUNT CARMEL, ISRAEL (1998)

Species diversity of epilithic cyanobacteria was studied in a 90 m deep prehistoric el-Wad cave eroded in Cenomanian limestones of Mount Carmel, Israel. The degree of illumination is the most variable index throughout the cave, whereas humidity and temperature vary moderately. In a number of sites inside the cave dripping water occurs due to filtration of rain water. In el-Wad cave 42 species from 20 genera of blue-green algae were found. The share of coccoid forms decreased and filamentous (especially oscillatorial) ones increased from the entrance to the end of the cave. Intensity of light was the governing factor for distribution of cyanobacteria in el-Wad cave; the availability of dripping affected it to a lesser extent due to the constantly high humidity of the air. Diversity of species composition and taxonomic spectrum of cyanophytes was reduced from the entrance to the end of the cave, covarying positively with darkness stress.
Thin-film lumped-element microwave filters (2003)

A method for the design and construction of thin-film lumped-element microwave filters is presented. The resulting filters exhibit broad spurious-free stopbands, small physical size, excellent amplitude and phase match, and high reliability due to their thin film construction. The necessary models for inductors and capacitors are discussed. Multilayer thin-film techniques make the construction of these filters efficient and cost-effective. Experimental results on several filters are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cholecystokinin Decreases Intestinal Hexose Absorption by a Parallel Reduction in SGLT1 Abundance in the Brush-Border Membrane (1998)

The dual lumenaly and vascularly perfused small intestine was used to determine the mechanism by which cholecystokinin octapeptide (CCK-8) decreases the rate of glucose absorption. With CCK-8 in the vascular perfusate the rate of 3-O-methyl-D-glucose absorption decreased, whereas the rate of D-fructose absorption was unaffected. The substrate pool size within the tissue during steady-state transport, in the presence and absence of CCK-8, was estimated by compartmental analysis of the 3-O-methyl-D-glucose washout into the vascular bed. When CCK-8 was included in the vascular perfusate, the absorptive cell pool size decreased when compared with untreated tissue. Both the steady-state hexose absorption data and the washout studies indicated that the locus of action of CCK-8 was the SGLT1 transporter located in the brush-border membrane. The SGLT1 protein abundance in isolated brush-border membranes, as quantified by Western blotting, showed a decrease that paralleled the decrease in the steady-state transport rate induced by CCK-8. These results indicate that CCK-8 diminishes the rate of intestinal hexose absorption by decreasing SGLT1 protein abundance in the brush-border membrane of the rat jejunum and therefore provides evidence for acute enteric hormonal regulation of the rate of glucose absorption across the small intestine.
Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains (2016)

Soluble amyloid-beta (Aβ) aggregates likely contribute substantially to the dementia that characterizes Alzheimer's disease. However, despite intensive study of in vitro preparations and animal models, little is known about the characteristics of soluble Aβ aggregates in the human Alzheimer's disease brain. Here we present a new method for extracting soluble Aβ aggregates from human brains, separating them from insoluble aggregates and Aβ monomers using differential ultracentrifugation, and purifying them >6000 fold by dual antibody immunoprecipitation. The method resulted in <40% loss of starting material, no detectible ex vivo aggregation of monomeric Aβ, and no apparent ex vivo alterations in soluble aggregate sizes. By immunoelectron microscopy, soluble Aβ aggregates typically appear as clusters of 10-20 nanometer diameter ovoid structures with 2-3 amino-terminal Aβ antibody binding sites, distinct from previously characterized structures. This approach may facilitate investigation into the characteristics of native soluble Aβ aggregates, and deepen our understanding of Alzheimer's dementia.
Study on the problem of routing, wavelength and time-slot assignment toward optical time-slot switching technology (2010)

In this paper, we propose and evaluate the optical time-slot switching (OTS) technology, in which the fixed size time-slot is adopted as the basic switching granularity, and switching is done in the time domain, rather than wavelength domain. Subsequently, the routing, wavelength and time-slot assignment (RWTA) problem is studied. An adaptive weight function is introduced to the routing and wavelength selection algorithm, and several useful approaches, such as the train approach, wagon approach and p-distribution approach, are presented for the time-slot assignment and scheduling. The results show that our scheme can perform better than conventional OBS in the aspect of blocking performance, quality of service and class of service.
Ceramides from Urtica dioica roots (1991)

Abstract In methanolic extracts of stinging nettle roots (Urtica dioica) a special class of ceramides was detected. These ceramides contain a double bond in position 8 of the sphingoid base. With the typical amidic linkage the amino group of the sphingoid base (2‐amino‐1,3,4‐trihydroxy‐8‐octadecene) is either connected to an unbranched fatty acid with 20 – 25 carbon atoms or to a 2‐hydroxy fatty acid with the same chain length. Both classes of ceramides were separated from each other by thinlayer chromatoraphy. The members of each class were further separated as trimethylsilyl derivatives by gas chromatography. The structures of the ceramides were determined by mass, NMR and IR spectroscopy combined with hydrolysis experiments.
Adaptive Aberration Correction of Abdominal Images Using PARCA (1997)

Clinical images of the abdomen may be degraded by aberrations due to propagation through the abdominal wall, resulting in loss of contrast and reduction in overall image quality. The Parallel Adaptive Receive Compensation Algorithm (PARCA) uses multiple receive beams to compensate for these aberrations. Previous studies have demonstrated that PARCA can restore image quality in tissue-equivalent phantoms scanned with controlled phase and amplitude fluctuations. In this study, PARCA is used to improve clinical images of the abdomen. PARCA processed images show both improved contrast of structures and improved overall image quality.
The 59 kDa FK506-binding protein, a 90 kDa heat shock protein binding immunophilin (FKBP59-HBI), is associated with the nucleus, the cytoskeleton and mitotic apparatus (1995)

FKBP59-HBI, a 59 kDa FK506 binding protein which binds the 90 kDa heat shock protein hsp90 and thus is a heat shock protein binding immunophilin (HBI), was originally discovered in association with unliganded steroid receptors in their heat shock protein containing heterooligomer form. It belongs to a growing family including other FKBPs which bind the immunosuppressants FK506 and rapamycin, and cyclophilins which bind cyclosporin A, all having rotamase (peptidyl-prolyl cis-trans isomerase) activity which may be involved in protein folding. Targets for drug-immunophilin complexes have been mostly studied in vivo in T lymphocytes; however, immunophilins are present in all cell types, where their role and distribution are still unknown. Here we report the localization of FKBP59-HBI in various non lymphoid cells (mouse fibroblasts (L-929), monkey kidney cells (Cos-7), Madin-Darby canine kidney epithelial cells (MDCK), and mouse neuronal cells (GT1)). Two polyclonal antipeptide antibodies directed against the C-terminal end (amino acids 441-458) (Ab 173) or the sequence 182-201 (Ab 790) of the FKBP59-HBI were used in light and confocal laser immunofluorescence. FKBP59-HBI was found in the cytoplasm and nucleus of interphase cells. Specific immunofluorescence was much stronger in the cytoplasm than in the nucleus when using Ab 173, and stronger in the nucleus than in the cytoplasm with Ab 790. Detailed observations of L-cells, which have a particularly flat morphology, showed a punctate as well as a fibrous cytoskeletal staining in the cytoplasm using antibody 173, a result which suggests interactions of FKBP59-HBI with an organized network. Colocalization experiments (using antibodies against tubulin, vimentin or actin) and use of cytoskeletal-disrupting drugs revealed partial association of FKBP59-HBI with the microtubules. Western blot experiments confirmed that the protein was present in the subcellular fractions containing either 'soluble' proteins released from cells exposed to NP40 detergent, or proteins released from the cytoskeleton exposed to calcium ions (i.e. in microtubule depolymerizing conditions). Exposure of cells to 1 microM FK506 and rapamycin for 1 hour did not modify significantly the staining, although rapamycin treatment rendered the network stained by 173 clearly visible. Interestingly, during mitosis FKBP59-HBI segregated from the region of the chromosomes; it mainly localized with the mitotic apparatus (centrosome, spindle and interzone separating the chromosomes), the cleavage furrow and the midbodies during cytokinesis. It appeared again as a fibrous network in the cytoplasm of the two daughters cells.(ABSTRACT TRUNCATED AT 400 WORDS)
Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. (1998)

The homeodomain transcription factor insulin promoter factor-1 (IPF-1) is required for development of the pancreas and also mediates glucose-responsive stimulation of insulin gene transcription. Earlier we described a human subject with pancreatic agenesis attributable to homozygosity for a cytosine deletion in codon 63 of the IPF-1 gene (Pro63fsdelC). Pro63fsdelC resulted in the premature truncation of an IPF-1 protein which lacked the homeodomain required for DNA binding and nuclear localization. Subsequently, we linked the heterozygous state of this mutation with type 2 diabetes mellitus in the extended family of the pancreatic agenesis proband. In the course of expressing the mutant IPF-1 protein in eukaryotic cells, we detected a second IPF-1 isoform, recognized by COOH- but not NH2-terminal-specific antisera. This isoform localizes to the nucleus and retains DNA-binding functions. We provide evidence that internal translation initiating at an out-of-frame AUG accounts for the appearance of this protein. The reading frame crosses over to the wild-type IPF-1 reading frame at the site of the point deletion just carboxy proximal to the transactivation domain. Thus, the single mutated allele results in the translation of two IPF-1 isoproteins, one of which consists of the NH2-terminal transactivation domain and is sequestered in the cytoplasm and the second of which contains the COOH-terminal DNA-binding domain, but lacks the transactivation domain. Further, the COOH-terminal mutant IPF-1 isoform does not activate transcription and inhibits the transactivation functions of wild-type IPF-1. This circumstance suggests that the mechanism of diabetes in these individuals may be due not only to reduced gene dosage, but also to a dominant negative inhibition of transcription of the insulin gene and other beta cell-specific genes regulated by the mutant IPF-1.
Low complexity, real-time adjusted power management policy using Golden Section Search (2013)

Golden Section Search (GSS) is applied to optimize the time threshold in a time-out power management policy. To reduce power consumption, modern system on chips selectively turns off some of its idling parts. If an idling block is kept awake for too long, it is wasting power; if it fails to predict a request, it will reduce the system performance due to wake-up time. The request of each part depends on external random events. This problem is usually addressed with a time-out policy, where the time-out value must be optimized in real time to cope with the system usage characteristics. Without the aid of prior knowledge, the GSS driven power policy consumed 15% more power than the absolute lower bound and 7% more power than the best fixed time threshold with a priori knowledge. The proposed method was evaluated with interrupt data of a 2G modem, captured from a real device in use.
Production of active Serratia marcescens metalloprotease from Escherichia coli by alpha-hemolysin HlyB and HlyD (1992)

Serratia marcescens produces an abundant extracellular metalloprotease. The gene for this protease had previously been cloned and expressed in Escherichia coli, in which no functional protease could be found. However, the protease gene carries the LXGGXGND repeat motif found in alpha-hemolysin and other proteins secreted by homologous systems. Using a dual-plasmid complementation system, we show that the alpha-hemolysin hlyB and hlyD transport determinants are sufficient to allow secretion and activation of a functional metalloprotease species from E. coli, as are the comparable protease secretion functions of Erwinia chrysanthemi. However, strains expressing protease with the hlyBD transport system are unstable and rapidly lose the ability to produce functional protease.
Data partitioning schemes for the parallel implementation of the revised simplex algorithm for LP problems (2002)

The parallel implementation of the revised simplex algorithm (RSA) using eta-factorization holds the promise of significant improvement in the execution time by virtue of the existence of a high degree of parallelism in the computation within an iteration of the algorithm. However, the scheme employed to partition key data structures in a distributed memory parallel processor has a great impact on the achievable performance. The paper explores the trade-offs between block-row and block-column partitioning schemes for the matrix of constraint coefficients vis-a-vis the communication overheads and granularity of parallel computations. The results of an approximate analysis of the compute-communication balance are compared with measurements from practical implementation of the partitioning schemes on C-DAC's PARAM 8000 distributed memory parallel processor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Performance of 256ch flat panel PS-PMT with small crystals for a DOI PET detector (2004)

A 256ch flat panel position sensitive photomultiplier tube (256ch FP-PMT) was evaluated for application to a depth of interaction (DOI) PET detector composed of small crystal elements. The 256ch FP-PMT has 52 mm/spl times/52 mm opening area with 89% useful area. Its 256 anodes are placed at a 3.04 mm interval. To estimate the FP-PMT performance, light spread functions of anodes at central and peripheral regions of a prototype 256ch FP-PMT were measured with a Gd/sub 2/SiO/sub 5/ (GSO) crystal sized 1.42 mm/spl times/1.42 mm/spl times/4.5 mm, one quarter of the area of the FP-PMT anode area. It was found that light spread functions of peripheral anodes were similar to the functions of central anodes and also the functions measured with a 2.9 mm/spl times/2.9 mm/spl times/7.5 mm GSO crystal, almost the same size as the anode area. Transit time fluctuation among the 256ch FP-PMT anodes was estimated by measuring time resolutions of a LuYSiO/sub 5/ (LYSO) crystal at some central and peripheral positions. The LYSO crystal has the same dimensions as the smaller GSO crystal BaF/sub 2/ was used for a reference detector. The obtained distributions show about the same time resolution between the central and peripheral positions and the full width at half maximum is (366/spl plusmn/15) ps. The transit time fluctuation is /spl plusmn/106 ps. Two-dimensional position histograms of a 32/spl times/32 GSO crystal array and two layers of 9/spl times/9 GSO crystal arrays are obtained by uniform gamma-ray irradiation. The crystal dimensions are 1.42 mm/spl times/1.42 mm/spl times/4.5 mm. The 32/spl times/32 array covers all the useful area. The 9/spl times/9/spl times/2 array is coupled to peripheral region. The resultant histograms confirm that a 256ch FP-PMT has enough capability for identifying crystals of this size even on the periphery.