gebhart/patrepeval huggingface dataset:
Development of concave-convex imaging mirror system for a compact and achromatic full-field x-ray microscope (2017)

A full-field X-ray microscope utilizing advanced Kirkpatrick–Baez optics, which comprises four concave mirrors, provides high-resolution X-ray images without chromatic aberration. However, a large distance is required between the mirrors and the detector to obtain sufficiently high magnification factor. To achieve reduce this distance, this paper proposes a novel X-ray imaging mirror system consisting of two pairs of concave and convex mirrors, which enables the effective focal length to be decreased by shifting the principal surface. For developing the proposed optics, the mirrors were fabricated with an ion beam figuring system and stitching interferometer, developed by our group, with a peak-to-valley accuracy of ~2 nm. Analysis results indicate that the fabricated mirrors can achieve nearly diffraction-limited imaging performance. We report the mirror fabrication results and the characteristics of the fabricated mirrors.
Topical suplatast tosilate (IPD) ameliorates Th2 cytokine-mediated dermatitis in caspase-1 transgenic mice by downregulating interleukin-4 and interleukin-5 (2006)

This study shows that topical therapy with IPD inhibits the expression of IL-4 and IL-5 and ameliorates skin manifestations in an AD mouse model, suggesting the potential usefulness of topical IPD for the treatment of AD.
On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity. (1986)

Membrane assembly of complement proteins C5b-9 on human platelets results in a dose-dependent increase in the binding of coagulation factors Va and Xa to the plasma membrane, concomitant with a marked increase in platelet prothrombinase activity. Factor Va binding increased by 6-15-fold in platelets treated with the C5b-9 proteins as compared to controls. In the presence of near-saturating concentrations of factor Xa, factor Va binding to C5b-9-treated platelets approximately doubled. In the absence of added factor Va, C5b-9-treated platelets bound 1700 molecules of factor Xa versus 50 molecules/cell bound to controls, suggesting that C5b-9 assembly on the platelet surface initiates the release of platelet factor V from the alpha-granules. The capacity of the C5b-9 proteins to initiate the nonlytic release of the platelet alpha-granule storage pool was confirmed by assay for platelet factor 4. When measured in the presence of exogenous factor Va (2 micrograms/ml), factor Xa uptake by C5b-9 platelets increased to approximately 5500 molecules/cell (versus 330 molecules/cell for controls). Removal of external Ca2+ inhibited the C5b-9-initiated release of the alpha-granule storage pool and reduced by approximately 50% the expression of new factor Va binding sites, suggesting that these two events contributing to increased platelet prothrombinase activity are mediated in part by the influx of Ca2+ across the C5b-9 pore.
Small molecule organic light-emitting diodes can exhibit high performance without conventional hole transport layers (2002)

It is generally accepted that hole transport layers (HTLs) with thicknesses on the order of tens of nm are indispensable to the function of small molecule organic light-emitting diodes (OLEDs) if high electroluminescence and quantum efficiencies are to be achieved. In the present letter, small molecule OLEDs with high luminance and external quantum efficiencies are fabricated in which the HTL is replaced solely by an ultrathin (1–2 nm) self–assembled, saturated hydrocarbon organosiloxane monolayer. These results require some reconsideration of conventional design criteria regarding the necessity of HTLs and argue that the role of the self-assembled monolayer here is to enhance hole injection and charge recombination efficiency, while blocking electron transport to the anode. These results therefore offer significantly simplified device fabrication.
ELECTROMAGNETIC COMPOSITE-BASED REFLECTING TERAHERTZ WAVEPLATES (2011)

We have created a low profile, high efficiency half waveplate for operation at terahertz (THz) frequencies. The waveplate is a periodic gold/polyimide composite with a physical thickness of λ/10. Our reflection based waveplate has an intensity throughput of 80% at the design frequency of 350 GHz. This is quite high in comparison to transmissive THz components which typically suffer a large insertion loss due to Fresnel reflections. Simulations suggest a halfwave rotation of over 99% of the reflected THz radiation from 320 – 372 GHz. Experiments at 350 GHz confirm the basic operation of our electromagnetic composite as a functional half waveplate.
High Gain and High Power Organic Dye-Doped Polymer Optical Fiber Amplifiers: Absorption and Emission Cross Sections and Gain Characteristics (1997)

Amplification of high signal gain (36 dB, approximately 4000 times) and high output power (1200 W) was achieved in a Rhodamine B (RB)-doped graded-index (GI) polymer optical fiber amplifier (POFA) based on a prediction in which absorption and emission cross section data were used. The absorption and emission cross section spectra of RB, Rhodamine 6G, and 4-Dicyanmethylene-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (DCM) in poly(methyl methacrylate) (PMMA) bulk were determined. The cross section data enable us to predict gain characteristics of RB, R6G, and DCM-doped GI POFA. The wide spectral coverage in the visible is achievable with the GI POFAs doped with several selected dyes.
Bioactive Cyanoacrylate-Based Filling Material for Bone Defects in Dental Applications (2005)

We tried to prepare a new filling material for bone defects using β-Tricalcium phosphate (β-TCP) particles and Histoacryl®. The aim of this study was to evaluate physical and bioactive properties of cyanoacrylate-based filling materials for bone defects in the dental field. The shear bond strength values of the Histoacryl® and β-TCP/ Histoacryl® compounds stored in double-distilled water decreased with the increase of the amount of added β-TCP. The temperature change of the β-TCP/ Histoacryl® compounds during polymerization decreased compared to that of the Histoacryl®. The cytotoxicity of the filling materials decreased when the amount of added β-TCP was increased. In the evaluation of bioactivity, hydroxyapatite (HA) was precipitated on the surface and inner space of the porous filling material 4 weeks after immersion in SBF. This precipitation of HA on the surface of the filling material was also confirmed in the XRD result. These results indicate that our novel β-TCP/Histoacryl® compounds have the potential to serve as filling materials for bone defects in the dental field.
Room-temperature catalyst-free methane chlorination (2021)

The chlorination of methane presents a route for the upgrading of natural gas to value-added products. However, due to the low reactivity of methane, existing chlorination processes require the use of elevated temperatures and catalysts. Here, we report a simple process for the chlorination of methane at near-ambient temperatures using minimal reagents and no catalysts or external sources of energy. The reaction is carried out in an aqueous medium with trichloroisocyanuric acid as a chlorinating agent. The dissolution of trichloroisocyanuric acid in water leads to the sustained and buffered release of hypochlorous acid, which triggers the chlorination of methane by a free-radical mechanism. The process is also general to other alkanes, as shown by a similar chlorination of ethane. Further developments are required for this process to be deployed as a practical method of chloromethane production.
High-Resolution Enabled 5-plex Mass Defect-Based <i>N</i>,<i>N</i>-Dimethyl Leucine Tags for Quantitative Proteomics (2019)

A mass defect-based labeling strategy provides high accuracy as an MS<sup>1</sup>-centric quantification method, avoiding the ratio compression that affects isobaric label-based reporter ion quantification. We have developed cost-effective 5-plex mass defect N, N-dimethyl leucine (mdDiLeu) tags for quantification of various biological samples with increased multiplexing at a given resolving power afforded by the addition of mass difference isotopologues. The combination of mass difference and mass defect produces two labeled peak clusters separated by 5 Da in MS<sup>1</sup> spectra that are detected as five isotopic peaks at high resolution with mass differences of 15, 17, and 18 mDa per tag. Synthesis of each of the 5-plex mdDiLeu tags is accomplished by a single straightforward reaction step, making it accessible to any lab. To demonstrate 5-plex mdDiLeu for quantitative proteomics, we perform proof-of-principle experiments of mdDiLeu-labeled Saccharomyces cerevisiae lysate digest on an Orbitrap Fusion Lumos mass spectrometer.
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor (2018)

The Hippo signaling pathway is a conserved regulator of organ size and has important roles in the development and cancer biology. Due to technical challenges, it remains difficult to assess the activity of this signaling pathway and interpret it within a biological context. The existing literature on large tumor suppressor (LATS) relies on methods that are qualitative and cannot easily be scaled-up for screening. Recently, we have developed a bioluminescence-based biosensor to monitor the kinase activity of LATS-a core component of the Hippo kinase cascade. Here, we describe procedures for how this LATS biosensor (LATS-BS) can be used to characterize Hippo pathway regulators. First, we provide a detailed protocol for investigating the effect of an overexpressed protein candidate (e.g., VEGFR2) on LATS activity using the LATS-BS. Then, we show how the LATS-BS can be used for a small-scale kinase inhibitor screen. This protocol can feasibly be scaled-up to perform larger screens, which undoubtedly will identify novel regulators of the Hippo pathway.
A mixed-mode esd protection circuit simulation-design methodology (2003)

On-chip electrostatic discharge (ESD) protection design becomes a major design challenge as IC technologies continue to migrate into very-deep-submicron (VDSM) regime. However, trial-and-error approaches still dominate in ESD protection circuit design. This paper discusses a new mixed-mode ESD protection simulation-design methodology, aiming to design prediction, which involves multiple-level coupling in ESD protection simulation by solving complex electrothermal equations self-consistently at process, device, and circuit levels in a coupled fashion to investigate ESD protection circuit details without any pre-assumption. Practical ESD protection design examples, implemented in commercial 0.18/0.35-μm CMOS and BiCMOS processes, are presented.
Transparent conductive metal-oxide contacts in vertical-injection top-emitting quantum well lasers (1991)

Optically transparent and electrically conductive cadmium tin oxide is employed in vertical cavity surface-emitting lasers for vertical current injection. Continuous wave lasing at room temperature is achieved in GaAs/AlGaAs quantum well lasers. Devices with a 10 μm optical window, which also serves as a vertical current injection inlet, give lasing threshold currents as low as 3.8 mA. The differential series resistance is 350–450 Ω with a diode voltage of 5.1–5.6 V at lasing threshold. Far-field pattern of the laser emission is Gaussian-like with a full width at half maximum of 7°.
Assessment of effects of packet loss on speech quality in VoIP (2004)

This paper investigates the effects of packet loss on speech quality in Voice over Internet Protocol (VoIP) applications by using ITU-T G.107, the E-model, whose parameters currently only cover limited VoIP scenarios. Several packet loss rates, packet sizes and error concealment techniques for codec G.729 are examined. Mean Opinion Score (MOS) is used as an index for speech quality and is measured by Perceptual Evaluation of Speech Quality (PESQ) algorithm. These effects on speech quality are assessed in the equipment impairment factor domain and then formulated into the E-model. The validation test shows good accuracy of the proposed formula, the prediction errors range between /spl mnplus/0.10 MOS for most cases with an absolute maximum of 0.14 MOS.
Extraction of Carrier Phase Delay for Nonlinear Errors Compensation of PGC Demodulation in an SPM Interferometer (2019)

Traditional phase generated carrier (PGC) schemes require that the carrier phase delay be kept zero and the phase modulation depth be maintained at a certain value; otherwise, serious nonlinear errors will be introduced into the phase demodulation of a sinusoidal phase modulation interferometer. Proposed herein is a robust carrier phase delay extraction method for nonlinear errors compensation of PGC demodulation that mitigates the effect of the interference phase shift. The carrier phase delay is directly extracted by adopting the first-, second-, and fourth-order in-phase and quadrature harmonic components generated by quadrature multi-harmonics frequency down conversion. Further, with the extracted phase delay, real-time compensations for the phase delay and phase demodulation depth are realized simultaneously in PGC demodulation. Theoretical analysis and derivation of the proposed method are given in detail. Simulation and displacement measurement experiments with different phase delays and phase modulation depths are performed to verify the effectiveness of the proposed method. The experimental results demonstrate that the proposed method is able to precisely extract the phase delay and efficiently eliminate the effects of the phase delay and modulation depth instability.
On generating near-optimal tableaux for conditional functional dependencies (2008)

Conditional functional dependencies (CFDs) have recently been proposed as a useful integrity constraint to summarize data semantics and identify data inconsistencies. A CFD augments a functional dependency (FD) with a pattern tableau that defines the context (i.e., the subset of tuples) in which the underlying FD holds. While many aspects of CFDs have been studied, including static analysis and detecting and repairing violations, there has not been prior work on generating pattern tableaux, which is critical to realize the full potential of CFDs. This paper is the first to formally characterize a "good" pattern tableau, based on naturally desirable properties of support, confidence and parsimony. We show that the problem of generating an optimal tableau for a given FD is NP-complete but can be approximated in polynomial time via a greedy algorithm. For large data sets, we propose an "on-demand" algorithm providing the same approximation bound, that outperforms the basic greedy algorithm in running time by an order of magnitude. For ordered attributes, we propose the range tableau as a generalization of a pattern tableau, which can achieve even more parsimony. The effectiveness and efficiency of our techniques are experimentally demonstrated on real data.
Multiplex LCMS Bioanalysis of Brentuximab Vedotin, Rituximab and Cetuximab towards Therapeutic Drug Monitoring Application by Combined Calibration Curve Using Fab-Selective Limited Proteolysis nSMOL (2016)

Background: Recently, monoclonal antibody (mAb) bioanalysis using mass spectrometry has begun to be recognized as useful technology for mAbs measurement other than ELISA. We have recently exploited a high-precision method for bioanalysis of monoclonal antibody (mAb) using mass spectrometry. The method is nano-surface and molecular-orientation limited (nSMOL) proteolysis, which is useful for LCMS bioanalysis of many kinds of antibody drugs. Methods: nSMOL is Fab-selective limited proteolysis which consists of the difference of protease nanoparticle diameter (200 nm) and antibody resin pore diameter (100 nm). For limited proteolysis of antibody, Protein A resin (pore: 100 nm) slurry was added to plasma including monoclonal antibody, and the antibody Fc region was immobilized to the resin at 25°C for 10 min with gentle vortexing. Antibody-immobilized resin was washed with PBS, and limited proteolysis was performed with trypsin-conjugated FG beads (diameter: 200 nm). Limited proteolysis of Fab region on antibody was achieved by these two diameter difference. After nSMOL proteolysis, the generated peptides were collected by only simple filtration. Results: In this study, we have demonstrated that the first full validation dataset for bioanalysis using nSMOL of antibody-drug conjugate (ADC), Brentuximab vedotin, in human plasma using nSMOL proteolysis. Full validation using nSMOL proteolysis fulfilled criteria of guideline on bioanalytical method validation in pharmaceutical development for small molecule drug compounds. Conclusions: These results indicate that nSMOL is also significant method for precise quantification of ADC in plasma, such as Brentuximab vedotin. Furthermore, we report that nSMOL proteolysis is able to apply for not only single-analyte but also multi-analyte bioanalysis of each mAbs in plasma, so that, nSMOL proteolysis is feasible multiplex bioanalysis for many clinical pharmacokinetic study and therapeutic drug monitoring.
High‐Toughness Ce‐TZP/Al <sub>2</sub> O <sub>3</sub> Ceramics with Improved Hardness and Strength (1991)

Simulataneous additions of SrO and Al 2 O 3 to ZrO 2 (12 mol% CeO 2 ) lead to the in situ formation of strontium aluminate (SrO · 6Al 2 O 3 ) platelets (∼0.5 μm in width and 5 to 10 μm in length) within the Ce‐TZP matrix. These platelet‐containing Ce‐TZP ceramics have the strength (500 to 700 MPa) and hardness (13 to 14 GPa) of Ce‐TZP/Al 2 O 3 while maintaining the high toughness (14 to 15 MPa ± m 1/2 ) of Ce‐TZP. Optimum room‐temperature properties are obtained at SrO/Al 2 O 3 molar ratios between 0.025 and 0.1 for ZrO 2 (12 mol% CeO 2 ) with starting Al 2 O 3 contents ranging between 15 and 60 vol%. The role of various toughening mechanisms is discussed for these composite ceramics.
A methodology to help operators share the spectrum through an enhanced form of Carrier Aggregation (2014)

This paper analyses performance aspects and initial methodology for a form of spectrum sharing for cellular operators, based on an enhanced form of Carrier Aggregation. Our motivation is to provide the appropriate framework and encourage systematic spectrum sharing, taking into account Quality of Service (QoS) requirements that the cellular operators may have. The enhanced form of Carrier Aggregation combines statically assigned spectrum at 2 Ghz, with the spectrum resources from a shared spectrum pool. We also identify different forms of shared spectrum - the fee-paying, exclusively shared and free, commonly shared spectrum classes. In modelling the exclusively shared spectrum class, we broadly adopt approaches for the Licensed Shared Access and Priority Access, and focus on 2.3 GHz band. For the common band, we adopt the TV White Space model as a good fit and observe TV UHF channel 40 at 622-630 MHz. Our focus is a typical urban scenario, where macro cells at 2 GHz provide coverage and small cells are deployed to boost the capacity of the system while using the shared spectrum resources. Although the use of lower frequencies for low power nodes and higher frequencies for providing coverage and mobility may seem counter-intuitive, this may be a realistic case due to currently developed spectrum sharing models. To analyse system performance, we use 50%-ile and lowest 5%-ile user throughput as the metric, and define target capacities. The premise is that should free, commonly shared spectrum fail to meet the target capacities, the operator also resorts to the fee-paying, exclusively shared spectrum. Provided the availability of TV White Space channel, our results show that for a low number of users, the operator can meet target capacities by using maximum permitted power levels in that channel, without resorting to the fee-paying, exclusively shared band.
3‘-Chloro-3α-(diphenylmethoxy)tropane But Not 4‘-Chloro-3α- (diphenylmethoxy)tropane Produces a Cocaine-like Behavioral Profile (1997)

A series of 2'- and 3'-substituted and 3',3"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs were designed and synthesized as novel probes for the dopamine transporter. All the analogs were evaluated for displacement of [3H]WIN 35,428 binding at the dopamine transporter and for inhibition of [3H]dopamine uptake in rat caudate putamen. Compounds were observed to monophasically displace [3H]WIN 35,428 binding to the dopamine transporter with affinities of 21.6-1836 nM (Ki). Generally, meta-substituted compounds were more potent than benztropine and equipotent to or slightly less potent than their previously reported para-substituted homologs in inhibiting [3H]WIN 35,428 binding. However, these same meta-substituted analogs were typically less potent than the 4'-substituted analogs in inhibiting [3H]dopamine uptake. Ortho-substituted analogs were generally less potent in both binding and inhibition of uptake at the dopamine transporter than either benztropine or other aryl-substituted homologs. The analogs were also tested for binding at norepinephrine and serotonin transporters as well as muscarinic m1 receptors. None of the compounds in the present study bound with high affinity to either the norepinephrine or serotonin transporters, but all bound to muscarinic m1 receptors with high affinity (K1 = 0.41-2.52 nM). Interestingly, 3'-chloro-3 alpha-(diphenylmethoxy)tropane (5c) produced effects like cocaine in animals trained to discriminate 10 mg/kg cocaine from saline, unlike its 4'-Cl homolog and all of the previously evaluated benztropine analogs. Further evaluation of compound 5c and the other benztropine analogs will undoubtedly prove useful in the elucidation of the role of the dopamine transporter in the reinforcing effects of cocaine and the ultimate identification of a cocaine-abuse treatment.
Automated Diagnosis of Otitis Media: Vocabulary and Grammar (2013)

WE PROPOSE A NOVEL AUTOMATED ALGORITHM FOR CLASSIFYING DIAGNOSTIC CATEGORIES OF OTITIS MEDIA: acute otitis media, otitis media with effusion, and no effusion. Acute otitis media represents a bacterial superinfection of the middle ear fluid, while otitis media with effusion represents a sterile effusion that tends to subside spontaneously. Diagnosing children with acute otitis media is difficult, often leading to overprescription of antibiotics as they are beneficial only for children with acute otitis media. This underscores the need for an accurate and automated diagnostic algorithm. To that end, we design a feature set understood by both otoscopists and engineers based on the actual visual cues used by otoscopists; we term this the otitis media vocabulary. We also design a process to combine the vocabulary terms based on the decision process used by otoscopists; we term this the otitis media grammar. The algorithm achieves 89.9% classification accuracy, outperforming both clinicians who did not receive special training and state-of-the-art classifiers.
Development of smart transducer with embedded sensor for automatic process control of ultrasonic wire bonding (2005)

A ring-shaped lead zirconate titanate (PZT) piezoceramic sensor has been integrated with the Langevin-type piezoceramic driver of an ultrasonic wire-bonding transducer to form a smart transducer for in-situ measurement of three essential bonding parameters: namely, impact force, ultrasonic amplitude and bond time. This sensor has an inner diameter, an outer diameter and a thickness of 12.7 mm, 5.1 mm and 0.6 mm, respectively. It has a specifically designed electrode pattern on the two major surfaces perpendicular to its thickness along which polarization is induced. The process-test results have indicated that the sensor not only is sensitive to excessive impact forces exerted on the devices to be bonded but also can track changes in the ultrasonic amplitude proficiently during bonding. Good correlation between the sensor outputs and the bond quality has been established. This smart transducer has good potential to be used in automatic process-control systems for ultrasonic wire bonding.