gebhart/patrepeval huggingface dataset:
Evidence of a quinoprotein glucose dehydrogenase apoenzyme in several strains of Escherichia coli (1984)

When grown on glucose in K+-limited chemostat culture, or in batch culture with or without 2,4-dinitrophenol, several strains of Escherichia coli (including the type strain) were found to synthesize a quinoprotein glucose dehydrogenase apoenzyme. The pyridine nucleotides, NAD+ and NADP+, would not serve as cofactor, but activity could be demonstrated upon addition of 2,7,9-tricarboxy-1 H-pyrrolo(2,3-f)quinoline-4,5-dione (PQQ). Thus, in the presence of PQQ, but not in its absence, glucose was oxidized to gluconic acid. A mutant of E. coli PC 1000 was isolated that lacked Enzyme I of the phosphoenolpyruvate phosphotransferase system (PTS) but still synthesized the glucose dehydrogenase apoenzyme. Whereas this mutant would not grow on glucose in the absence of PQQ, it would do so in the presence of low concentrations (1 µM) of this cofactor. On the basis of these observations, it is concluded that the protein (apoenzyme) formed is a genuine glucose dehydrogenase, but that it is not functional in growing cells due to their inability to synthesize the appropriate cofactor (PQQ), at least under these conditions.
A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Acute Pulmonary Embolism (1997)

Under the conditions of this study, initial subcutaneous therapy with the low-molecular-weight heparin tinzaparin appeared to be as effective and safe as intravenous unfractionated heparin in patients with acute pulmonary embolism.
‘Forever chemicals’ no more? (2019)

At the Sweeney Water Treatment Plant in North Carolina, engineers are finalizing designs for a new system aimed at removing a mix of persistent industrial chemicals from their drinking water. These molecules are troublemakers—wily foes that have evaded capture by traditional water treatment methods. They’re known collectively as PFAS, the family of nonpolymer per- and polyfluoroalkyl substances nicknamed “forever chemicals.” The plant has been paying special attention to PFAS. The facility supplies water to roughly 200,000 customers, drawing the bulk of that water from the lower part of the Cape Fear River, which researchers in 2016 found to be contaminated with PFAS downstream from a fluorochemical-producing Chemours plant. The new facility will house four 12 m long beds of granular activated carbon, about 7 m wide and 3.7 m deep, to suck PFAS from the water. These beds are three times as deep as the plant’s existing ones, which it
Unusual <i>ipso</i> Substitution of Diaryliodonium Bromides Initiated by a Single‐Electron‐Transfer Oxidizing Process (2010)

Aromatic substitution: The treatment of diaryliodonium bromides 1 with aromatic nucleophiles 2, afforded a variety of heteroaryl-containing biaryls 3 in good yields. The ipso-substitution process at the heteroaryl ring in 1 occurs through the formation of aromatic cation radicals, which are initiated by the single-electron-transfer (SET) oxidation of 2. (HFIP= hexafluoroisopropanol)
Effect of Surface Water and Base Catalysis on the Silanization of Silica by (Aminopropyl)alkoxysilanes Studied by X-ray Photoelectron Spectroscopy and 13C Cross-Polarization/Magic Angle Spinning Nuclear Magnetic Resonance (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of Surface Water and Base Catalysis on the Silanization of Silica by (Aminopropyl)alkoxysilanes Studied by X-ray Photoelectron Spectroscopy and 13C Cross-Polarization/Magic Angle Spinning Nuclear Magnetic ResonanceKrishna M. R. Kallury, Peter M. Macdonald, and Michael ThompsonCite this: Langmuir 1994, 10, 2, 492–499Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/la00014a025https://doi.org/10.1021/la00014a025research-articleACS PublicationsRequest reuse permissionsArticle Views2742Altmetric-Citations204LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Applications of affinity interactions in capillary electrophoresis (2003)

Capillary electrophoresis (CE) has proven useful for the study of reversible molecular interactions. This is because highly efficient and reproducible separations take place in an environment where molecular interactions may contribute to selectivity without being inhibited by adverse buffer conditions. Affinity CE may be used to estimate quantitative binding data (binding constants and in some cases binding stoichiometries and rate constants) for various molecular interactions. Specific binding interactions (e.g., based on antibodies or aptamers) may also be utilized to quantitatively measure specific analytes using CE. Applications within these areas are here reviewed with focus on the last three years and with emphasis on novel concepts as well as innovative methodology and technology. It is concluded that the affinity CE approach is of growing versatility and will continue to play an integral role in discovering, characterizing, and exploiting biomolecular interactions.
Robust face presentation attack detection on smartphones : An approach based on variable focus (2017)

Smartphone based facial biometric systems have been well used in many of the security applications starting from simple phone unlocking to secure banking applications. This work presents a new approach of exploring the intrinsic characteristics of the smartphone camera to capture a number of stack images in the depth-of-field. With the set of stack images obtained, we present a new feature-free and classifier-free approach to provide the presentation attack resistant face biometric system. With the entire system implemented on the smartphone, we demonstrate the applicability of the proposed scheme in obtaining a stack of images with varying focus to effectively determine the presentation attacks. We create a new database of 13250 images at different focal length to present a detailed analysis of vulnerability together with the evaluation of proposed scheme. An extensive evaluation of the newly created database comprising of 5 different Presentation Attack Instruments (PAI) has demonstrated an outstanding performance on all 5 PAI through proposed approach. With the set ofcomplementary benefits of proposed approach illustrated in this work, we deduce the robustness towards unseen 2D attacks.
Synthesis and Structure–Activity Relationships of Lapacho Analogues. 2. Modification of the Basic Naphtho[2,3-<i>b</i>]furan-4,9-dione, Redox Activation, and Suppression of Human Keratinocyte Hyperproliferation by 8-Hydroxynaphtho[2,3-<i>b</i>]thiophene-4,9-diones (2014)

The basic structure of linearly anellated lapacho quinones, naphtho[2,3-b]furan-4,9-dione (7), was modified in the search for novel agents against keratinocyte hyperproliferation. The synthesis and structure-activity relationships of several heterocycle-fused naphthoquinones as well as a full range of 2- and 7-substituted derivatives of one of these, 8-hydroxynaphtho[2,3-b]thiophene-4,9-dione (8a), are described. Out of a total of 71 analogues, particularly 2-thenoyl-substituted 26l, 2-nicotinoyl-substituted 26m, and 2-oxadiazole-substituted 35a compared favorably with the antipsoriatic agent anthralin. Their potency for suppression of keratinocyte hyperproliferation, which was evaluated using HaCaT cells as a model, was combined with comparably low membrane-damaging effects toward keratinocytes, as established by the release of lactate dehydrogenase activity from the cytoplasm of the cells. With respect to the mechanism of action, redox activation of lapacho quinones by one- and two-electron reduction in isolated enzymatic assays was studied, and their potential to generate superoxide was confirmed in the keratinocyte-based hyperproliferation assay.
El aprendizaje cooperativo como estrategia para la inclusión del alumnado con tea/as en el aula ordinaria (2017)

Este estudio pretende indagar y examinar el trabajo realizado en las aulas con alumnos/as que presentan Trastorno del Espectro Autista y/o sindrome Asperger. El objetivo es orientar a los docentes que trabajan por la inclusion de este alumnado acerca de algunas estrategias educativas de caracter cooperativo para que la intervencion educativa con estos ninos/as sea satisfactoria. Se ha realizado un analisis de necesidades para disenar un plan de apoyo dirigido a favorecer la inclusion del alumnado con TEA/AS en el aula ordinaria mediante estrategias de aprendizaje cooperativo. Para la recogida de datos se han utilizado estrategias tanto cualitativas y cuantitativas: entrevistas individuales, cuestionarios cerrados y escala de observacion. En la muestra han participado profesorado de educacion Infantil y Primaria, alumnado, orientadora, educadora especial, monitora de apoyo especifico, pedagoga terapeutica y profesional de Audicion y Lenguaje. Los resultados muestran las barreras que hallan los educadores para trasladar el concepto de «inclusion» a la realidad del aula del alumnado que presenta estas caracteristicas
The oxygenation of murine tumor isografts and human tumor xenografts by nicotinamide. (1992)

The changes in pO2 caused by nicotinamide in the FSaII mouse tumor and three different xenografts of human tumors, HP-56, FaDu, and EO1, grown subcutaneously in the legs of mice were studied. The tumor pO2, as measured with microelectrodes, began to rise soon after the host mice were injected intraperitoneally with 500 mg/kg nicotinamide, and it increased continuously for 100-120 min. The rate and magnitude of the increase in tumor pO2 was dependent on the tumor line and also on the tumor size. In FSaII tumors, the increase in pO2 caused by nicotinamide was relatively small in the well-oxygenated small tumors (173 +/- 5 mm3) compared with that in the larger tumors (515 +/- 25 mm3). The blood perfusion in FSaII tumors as measured with the laser Doppler method was also increased by nicotinamide. The growth delay in FSaII tumors induced by X irradiation was enhanced significantly by nicotinamide. It was concluded that the enhancement of radiation damage in the experimental tumors in mice by nicotinamide, as observed in the present study and reported by others, is due to an increase in intratumor pO2, possibly as a result of an increase in blood perfusion.
Catalyst-free site-specific surface modifications of nanocrystalline diamond films via microchannel cantilever spotting (2016)

Microchannel cantilever spotting is combined with a copper-free click chemistry ligation to achieve the patterning of nanocrystalline diamond films.
<title>Model selection based on robustness criterion with measurement application</title> (1999)

Huber's approach to robust estimation is highly fruitful for solving estimation problems with contaminated data or under incomplete information according to the error structure. A simple selection procedure based on robustness to variations of the errors distribution from the assumed one, is proposed. Minimax M-estimator is used to estimate efficiently the parameters and the measurement quantity. A performance deviation criterion is computed by the mean of the Monte Carlo method improved by the Latin Hypercube Sampling. The selection produced is applied to a real measurement problem, grooves dimensioning using Remote Field Eddy Current inspection.
Sequence-to-Sequence Automatic Speech Recognition with Word Embedding Regularization and Fused Decoding (2020)

In this paper, we investigate the benefit that off-the-shelf word embedding can bring to the sequence-to-sequence (seq-to-seq) automatic speech recognition (ASR). We first introduced the word embedding regularization by maximizing the cosine similarity between a transformed decoder feature and the target word embedding. Based on the regularized decoder, we further proposed the fused decoding mechanism. This allows the decoder to consider the semantic consistency during decoding by absorbing the information carried by the transformed decoder feature, which is learned to be close to the target word embedding. Initial results on LibriSpeech demonstrated that pre-trained word embedding can significantly lower ASR recognition error with a negligible cost, and the choice of word embedding algorithms among Skip-gram, CBOW and BERT is important.
Immunoassays for carbodiimide modified DNA-detection of unpairing transitions in supercoiled ColE1 DNA (1989)

The water soluble reagent N-cyclohexyl-N'-beta-(4-methylmorpholinium) ethyl carbodiimide-p-toluene sulphonate (CMC) can be used to probe for unpaired and mismatched sites in DNA. Polyclonal antibodies for CMC modified DNA were produced in order to develop immunological assays for the localization and quantitation of CMC adducts. Immunoslot blot analysis of modified DNA exhibited antibody binding proportional to the extent of CMC modification with adduct detection in the femtamole range. Unmodified DNA did not cross react under the conditions of the assay. The distribution of CMC reactivity for supercoiled ColE1 DNA modified at 100, 200 and 300 mM NaCl was determined by immunoanalysis of EcoRI-Hae2-NruI restriction fragments Southern transferred to nylon membranes. Reactivity above random expectation occurred in the A2-II fragment which can be accounted for by its high A-T content of 71.3%. Reactivity below random expectation occurred in the C fragment which can be accounted for by its low AT content of 43%. CMC modification for the other restriction fragments appeared random.
Dependence on Fermi surface dimensions of oscillatory exchange coupling in Co/<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mi mathvariant="normal">−</mml:mi><mml:mi mathvariant="italic">x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ni</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="italic">x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>(110) multilayers (1993)

A significant change in the oscillatory exchange coupling corresponding to the contraction of the Fermi surface in spacer layers is found in the Co/${\mathrm{Cu}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{Ni}}_{\mathit{x}}$(110) system. The oscillation period becomes longer with increasing Ni concentration: from 12 \AA{} (0% Ni) to 23 \AA{} (35% Ni). This change manifests that the long-period oscillation across Cu-Ni(110) arises from the singularity at the neck orbit of the spacer Fermi surface. The neck diameters estimated from the measured periods are in good agreement with those of bulk Cu-Ni Fermi surfaces.
Synthesis and applications of isotopically labelled compounds 1994 : proceedings of the Fifth International Symposium, Strasbourg, France, 20-24 June 1994 (1995)

Stereoselective Procedures in the Synthesis of Enantiomerically Pure Isotopically Labelled Compounds Stereospecifically Labelled Compounds as Tools for Investigating Metabolic Processes Applications of Stable Isotope Labelling Techniques to Mechanistic Studies on the Metabolism and Toxicity of Valproic Acid A Half Century of Particle Physics.
Complete analysis of a two-mirror unit magnification system Part 1 (1983)

The characteristics of a two-mirror unit magnification system are investigated. This system consists of a concave mirror and a convex mirror and is optimized off-axis. In a concentric system, sagittal imagery has no aberration, whereas meridional imagery has higher-order field curvature and residual aberration. It is shown that the inclination is proportional to 1/Fe3 and the residual aberration to 1/Fe7 The limits of this system are also discussed.
Incremental Support Vector Learning: Analysis, Implementation and Applications (2006)

Incremental Support Vector Machines (SVM) are instrumental in practical applications of online learning. This work focuses on the design and analysis of efficient incremental SVM learning, with the aim of providing a fast, numerically stable and robust implementation. A detailed analysis of convergence and of algorithmic complexity of incremental SVM learning is carried out. Based on this analysis, a new design of storage and numerical operations is proposed, which speeds up the training of an incremental SVM by a factor of 5 to 20. The performance of the new algorithm is demonstrated in two scenarios: learning with limited resources and active learning. Various applications of the algorithm, such as in drug discovery, online monitoring of industrial devices and and surveillance of network traffic, can be foreseen.
Chronic Traumatic Encephalopathy: A Review (2012)

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that is a long-term consequence of single or repetitive closed head injuries for which there is no treatment and no definitive pre-mortem diagnosis. It has been closely tied to athletes who participate in contact sports like boxing, American football, soccer, professional wrestling and hockey. Risk factors include head trauma, presence of ApoE3 or ApoE4 allele, military service, and old age. It is histologically identified by the presence of tau-immunoreactive NFTs and NTs with some cases having a TDP-43 proteinopathy or beta-amyloid plaques. It has an insidious clinical presentation that begins with cognitive and emotional disturbances and can progress to Parkinsonian symptoms. The exact mechanism for CTE has not been precisely defined however, research suggest it is due to an ongoing metabolic and immunologic cascade called immunoexcitiotoxicity. Prevention and education are currently the most compelling way to combat CTE and will be an emphasis of both physicians and athletes. Further research is needed to aid in pre-mortem diagnosis, therapies, and support for individuals and their families living with CTE.
评《道德教育:品德、社团与理想》 (1990)

B.西克尔的《道德教育》一书努力探索各种道德理论和道德教育的方式,从历史上分析其作用与不足,总结出一套适于当前环境下道德教育的新理论。这本书提醒我们,在教师的自身教育方面存在着艰巨复杂的任务。如果道德教育是教师的中心任务,那么对于与该任务有关的所有问题必须进行全面考查。根据西克尔的观点,道德教育并不是能从教学过程中分割开来的小课题,对心理学研究或对学生的管理方法的研究等都是不可缺少的。如果教师能以各种形式从事道德教育,他们则不得进行漫长而艰难的探索。在学生中是否进行道
Addition-Type Polynorbornenes with Si(CH<sub>3</sub>)<sub>3</sub> Side Groups:  Synthesis, Gas Permeability, and Free Volume (2006)

Polymerization of norbornene bearing Si(CH3)3 groups in the 5-position with the opening of double bonds and its copolymerization with 5-(n-hexyl)norbornene were realized in the presence of nickel(II) naphthenate/methylaluminoxane catalyst system. The completely saturated homopolymer containing Si(CH3)3 group (APNSi) and a copolymer containing both Si(CH3)3 and n-hexyl side groups (ACPNHSi) were prepared. The polymers have molecular mass of about 300 000 and a high glass transition temperature (Tg > 340 °C). Gas permeation properties of the polymers obtained were studied. APNSi reveals unusually high gas permeation parameters, e.g., P(O2) of about 800 Barrer for different samples. This polymer also exhibits solubility controlled gas permeation: the permeability coefficients increase in the series of n-alkanes C1−C4 when the size of the penetrant increases. Free volume in addition type substituted polynorbornenes was studied using positron annihilation lifetime spectroscopy (PALS). This method indicated that very large sizes of free volume elements are characteristic for APNSi what explains its great gas permeability. Another interesting feature of this polymer is an independence of the annihilation parameters (lifetimes τi and intensities Ii) of temperature in a wide range of its variation. Thus, APNSi is a novel representative of high free volume, high permeability glassy polymers, and it is a potential material for gas separation membranes.
Epigenetics in liver disease (2014)

The aim of the review is to inform hepatologists of the emerging key epigenetic ideas of relevance to liver diseases that are highly likely to form a component of patient management and care in the next decade.
Data Center Cooling (2013)

The article discusses available technologies for reducing energy use for cooling data center facilities. This article addresses the energy savings and market potential of these strategies as well.
Micro<scp>RNA</scp>‐9 inhibits the gastric cancer cell proliferation by targeting <scp>TNFAIP</scp>8 (2017)

Abstract Background and objectives Micro RNA ‐9 is frequently dysregulated in many human carcinoma types, including gastric cancer (GC). Previous studies demonstrated that the expression of TNFAIP 8 in GC is correlated with tumour occurrence, development, invasion, metastasis and prognosis. However, till now, the relationship between Micro RNA ‐9 and TNFAIP 8 in GC has not been reported. Materials and methods Levels of miR‐9 and TNFAIP 8 expression in GC tissues and in human GC cell lines were studied using qualitative real‐time PCR ( qRT ‐ PCR ) and Western blotting. Cell viability was detected using the CCK ‐8 and clone formation assays. A dual‐luciferase reporter system was used to confirm the target gene of miR‐9. Results We found that the expression level of Micro RNA ‐9 in GC tissues and cell lines was significantly lower than that in adjacent non‐cancerous tissues and human immortalized gastric epithelial cell (GES) line, respectively. In addition, overexpression of Micro RNA ‐9 markedly inhibited GC cell proliferation in vitro and tumour growth in vivo. Further experiments revealed that TNFAIP 8 was a direct and functional target of Micro RNA ‐9 in GC and overexpression of Micro RNA ‐9 obviously down‐regulated the expression of TNFAIP 8, which was involved in the gastric carcinogenesis and cancer progression. Conclusion Our results suggested that Micro RNA ‐9‐ TNFAIP 8 might represent a promising diagnostic biomarker for GC patients and could be a potential therapeutic target in the prevention and treatment of GC.
A STUDY ON ENERGY SAVING POTENTIAL OF HYDRAULIC CONTROL SYSTEM USING SWITCHING TYPE CLOSED LOOP CONSTANT PRESSURE SYSTEM (2008)

Up to now, several types of hybrid systems have been developed to deduce energy consumption. Switching type closed loop constant pressure system (SCL-CPS) was proposed as one of feasible hybrid systems. SCL-CPS also uses flywheel, hydraulic accumulator and hydraulic power transmission as a traditional CPS but it has two alternatively high pressure lines. At a same time, one is used as the high pressure line and the other is the low one. Switching between them to overcome large hydraulic shock and noise considered as serious problems in traditional CPS. In this paper, energy saving potential of system is evaluated by considering effect of component efficiencies in system. Recovery efficiency during deceleration the wheel is estimated by simulation. The results indicate that proper determination of recovery time and operating pressure improves significantly energy recovery potential of the system.