gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Unexpected Role of Anionic Ligands in the Ruthenium‐Catalyzed Base‐Free Selective Hydrogenation of Aldehydes. (2014)

Abstract (Diamine)(diphosphine)ruthenium‐type complexes act as unprecedented catalysts for the hydrogenation of aldehydes by using sterically hindered carboxylates as anionic ligands.
Local Heat Transfer and Pressure Drop for Finned-Tube Heat Exchangers Using Oval Tubes and Vortex Generators (2001)

Abstract This paper presents the results of an experimental study of forced convection heat transfer in a narrow rectangular duct fitted with an elliptical tube and one or two a delta-winglet pairs. The duct was designed to simulate a single passage in a fin-tube heat exchanger. Heat transfer measurements were obtained using a transient technique in which a heated airflow is suddenly introduced to the test section. High-resolution local fin-surface temperature distributions were obtained at several times after initiation of the transient using an imaging infrared camera. Corresponding local fin-surface heat transfer coefficients were then calculated from a locally applied one-dimensional semi-infinite inverse heat conduction model. Heat transfer results were obtained over a Reynolds number range based on duct height of 670–6300. Pressure drop measurements have also been obtained for similar elliptical-tube and winglet geometries using a separate single-channel, multiple-tube-row pressure-drop apparatus. The pressure-drop apparatus includes four tube rows in a staggered array. Comparisons of heat transfer and pressure drop results for the elliptical tube versus a circular tube with and without winglets are provided. Mean heat transfer results indicated that the addition of the single winglet pair to the oval-tube geometry yielded significant heat transfer enhancement, averaging 38% higher than the oval-tube, no-winglet case. The corresponding increase in friction factor associated with the addition of the single winglet pair to the oval-tube geometry was very modest, less than 10% at ReDh = 500 and less than 5% at ReDh = 5000.
Cycline-A et Cancer (1993)

M du cycle.Elle s'asso cie au ssi à la protéine kinase p33 cdk2
Novel automated morphometric and kinematic handwriting assessment: A validity study in children with ASD and ADHD (2017)

This study presents construct validity for a novel automated morphometric and kinematic handwriting assessment, including (1) convergent validity, establishing reliability of automated measures with traditional manual-derived Minnesota Handwriting Assessment (MHA), and (2) discriminant validity, establishing that the automated methods distinguish populations of children with previously reported impairments in handwriting. Results revealed standard (manual derived) MHA, and comparable automated handwriting scores were highly correlated, providing evidence for convergent validity. Participants in the discriminant validity study included 167 children (ages 7–12 years old; 65 typically developing [TD], 45 attention-deficit/hyperactivity disorder [ADHD], and 57 autism spectrum disorder [ASD]). Repeated measures ANOVAs were employed to test for diagnostic differences across conditions and groups; follow-up correlations using letter form were conducted to identify associations between handwriting and neuropsychological performance. Diagnostic group comparisons provided evidence of discriminant validity, revealing elevated letter-form scores (worse performance) in children with ASD and ADHD groups compared to TD children; children with ASD showed the greatest letter-form impairment. These results provide strong evidence of construct validity for this novel automated handwriting assessment.
Magnetic bubbles—An emerging new memory technology (1975)

Magnetic bubbles-an emerging storage technique-promise to bridge the capacity-data retrieval time gap left vacant by magnetic core and semiconductor devices on one side and the electromechanical magnetic tape and disk on the other. Improvements in bubble materials, circuit processing, and device design have advanced bubble technology to where it is a solid candidate for applications requiring 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> -10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> bits and retrieval times less than 0.005 s. Bubble chips as large as 65 kbits are currently under development. In this paper, the reader is first introduced to the topics of bubble statics and bubble dynamics, including a discussion of hard bubbles. Next, the operation of bubble devices such as propagation, generation, detection, and replication is described, as well as chip organizations using these functions. Temperature plays an important role and its effect on domain generation and data longevity is described. Fabrication techniques for bubble chips used in prototype mass memory modules and an experimental memory for a repertory telephone are given as are the overall systems' performance. Details of a 32-pin dual in-line bubble package are described. Finally, some predictions into the future are attempted for this technology. This discussion includes self-structuring propagation of bubbles and the bubble lattice file memory concept.
Responses to Synthetic Aggregation Pheromones, Host-Related Volatiles, and Their Combinations byCarpophilusspp. (Coleoptera: Nitidulidae) in Laboratory and Field Tests (1993)

Journal Article Responses to Synthetic Aggregation Pheromones, Host-Related Volatiles, and Their Combinations by Carpophilus spp. (Coleoptera: Nitidulidae) in Laboratory and Field Tests Get access D. Blumberg, D. Blumberg 1 Department of Entomology, The Volcani Institute, Agricultural Research Organization, Bet Dagan 50250, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Kerat, M. Kerat 1 Department of Entomology, The Volcani Institute, Agricultural Research Organization, Bet Dagan 50250, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Goldenberg, S. Goldenberg 1 Department of Entomology, The Volcani Institute, Agricultural Research Organization, Bet Dagan 50250, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar R. J. Bartelt, R. J. Bartelt 2 National Center for Agricultural Utilization Research, USDA-ARS, 1815 University St., Peoria, IL 61604 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. N. Williams R. N. Williams 3 Department of Entomology, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 22, Issue 4, 1 August 1993, Pages 837–842, https://doi.org/10.1093/ee/22.4.837 Published: 01 August 1993 Article history Received: 07 January 1993 Accepted: 06 April 1993 Published: 01 August 1993
Liposome-Encapsulated Hemoglobin Processing Methods (1992)

An effective and safe red blood cell substitute is being developed based on double emulsion/evaporation techniques followed by high pressure homogenization to form liposome-encapsulated hemoglobin (LEH). Formulations are made up of hydrogenated phosphatidylcholine (PC, soy or egg), cholesterol, phosphatidylinositol (PI), and alpha-tocopherol in a molar ratio of 1:1:0.2:0.02, respectively. Resulting LEH-encapsulated hemoglobin (Hb) concentrations are greater than 80% of precursor Hb solutions. Met-Hb generation accompanying LEH processing appears to be small with only a 3% increase for encapsulated over precursor. These results correspond to an oxygen content for an LEH suspension sample (50% by volume LEH) of 15 volume% oxygen. Oxygen affinity and cooperativity values for LEH suspensions appear to be near the normal values expected for whole blood. The viscosity of LEH suspension samples (50% by volume LEH in phosphate-buffered saline containing 7.5 wt% albumin) were slightly higher than that of whole blood. The effect of shear rate on leakage of encapsulated Hb from LEH was small, i.e. 0.5% or less. Nearly total isovolemic exchange transfusion using a cannulated rat model demonstrates efficacy of LEH suspension samples. There appears to be no difference in rat internal organ weights between rats exchanged with control compared to rats exchanged with LEH. Circulation half-life following 50% isovolemic exchange-transfusion is about 15 to 18 hours.
Gases for possible use in diffuse-discharge switches (1982)

Desirable electron attachment and electron drift characteristics of gases for possible use in diffuse-discharge switches are indicated. Gas mixtures for possible use in externally sustained (e- beam) diffuse-discharge switches are suggested on the basis of electron attachment rate constants and electron drift velocities measured as a function of the density-normalized electric field E/N. Of particular promise are mixtures of Ar and C3F8.
Overexpression of Gs alpha protein in the hearts of transgenic mice. (1995)

Alterations in beta-adrenergic receptor-Gs-adenylyl cyclase coupling underlie the reduced catecholamine responsiveness that is a hallmark of human and animal models of heart failure. To study the effect of altered expression of Gs alpha, we overexpressed the short isoform of Gs alpha in the hearts of transgenic mice, using a rat alpha-myosin heavy chain promoter. Gs alpha mRNA levels were increased selectively in the hearts of transgenic mice, with a level 38 times the control. Despite this marked increase in mRNA, Western blotting identified only a 2.8-fold increase in the content of the Gs alpha short isoform, whereas Gs activity was increased by 88%. The discrepancy between Gs alpha mRNA and Gs alpha protein levels suggests that the membrane content of Gs alpha is posttranscriptionally regulated. The steady-state adenylyl cyclase catalytic activity was not altered under either basal or stimulated conditions (GTP + isoproterenol, GTP gamma S, NaF, or forskolin). However, progress curve studies did show a significant decrease in the lag period necessary for GppNHp to stimulate adenylyl cyclase activity. Furthermore, the relative number of beta-adrenergic receptors binding agonist with high affinity was significantly increased. Our data demonstrate that a relatively small increase in the amount of the coupling protein Gs alpha can modify the rate of catalyst activation and the formation of agonist high affinity receptors.
peerTalk: A Peer-to-Peer Multiparty Voice-over-IP System (2008)

Multiparty voice-over-IP (MVolP) services allow a group of people to freely communicate with each other via the Internet, which have many important applications such as online gaming and teleconferencing. In this paper, we present a peer-to-peer MVolP system called peerTalk. Compared to traditional approaches such as server-based mixing, peerTalk achieves better scalability and failure resilience by dynamically distributing the stream processing workload among different peers. Particularly, peerTalk decouples the MVolP service delivery into two phases: mixing phase and distribution phase. The decoupled model allows us to explore the asymmetric property of MVolP services (for example, distinct speaking/listening activities and unequal inbound/outbound bandwidths) so that the system can better adapt to distinct stream mixing and distribution requirements. To overcome arbitrary peer departures/ failures, peerTalk provides lightweight backup schemes to achieve fast failure recovery. We have implemented a prototype of the peerTalk system and evaluated its performance using both a large-scale simulation testbed and a real Internet environment. Our initial implementation demonstrates the feasibility of our approach and shows promising results: peerTalk can outperform existing approaches such as P2P overlay multicast and coupled distributed processing for providing MVolP services.
Optical slot synchronisation scheme (1992)

A scheme is presented that allows the synchronisation of packets at the input to an optical, synchronously-operated packet switch. The scheme requires only two delay modules and carries a penalty of 50% of the switch capacity.
KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma (2016)

These functional data implicating KCa1.1 in MPM cell migration support our integrative approach using MPM gene expression datasets to identify novel and potentially druggable targets.
Investigation of LaBr/sub 3/ Detector Timing Resolution (2006)

Lanthanum bromide (LaBr/sub 3/) scintillation detectors are currently being developed for use in time-of-flight (TOF) PET. In recent years, studies have been aimed at the parameterization of the LaBr/sub 3/ scintillation properties. We have utilized the findings of these studies in the development of simulation tools to investigate and predict the performance of TOF PET detectors of realistic geometries. Here, we present a model to simulate the combined scintillator and photomultiplier tube (PMT) response to incident photons. This model allows us to study the effects of crystal response, geometry, and surface finish, PMT response, transit time spread, and noise, as well as discrimination techniques on the coincidence resolving time achievable in various detector configurations. Results from the simulations are benchmarked against several experimental measurements with two different PMTs and LaBr/sub 3/ crystals of varying cerium concentration and geometry. A comparison is also made to the time resolution achievable with LYSO. Good agreement between measurement and simulation has been achieved with detectors consisting of 4/spl times/4/spl times/30 mm/sup 3/ crystals suitable for use in a TOF PET scanner. Ultimately, this guides the improvement of TOF detectors by identifying the individual contribution of each detector component on the time resolution that can be achieved.
Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products. (1997)

Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric multifunctional enzyme that is expressed only in subanatomical portions of the brain, T lymphocytes, and postmeiotic male germ cells. It is present in the nucleus of the cells in which it is expressed and can phosphorylate and activate the cyclic AMP response element binding proteins CREB and CREM tau in a manner analogous to protein kinase A. In the absence of Ca2+/calmodulin, CaMKIV is inactive. Activation requires three events: 1) binding of Ca2+/calmodulin; 2) phosphorylation of a single threonine residue present in the activation loop by a separate protein kinase that is also Ca2+/calmodulin-dependent; and 3) autophosphorylation of serine residues present in the extreme N-terminus that is required to relieve a novel form of autoinhibition. The gene for rat CaMKIV has been cloned and found to span 42 kb of DNA. The gene encodes three proteins: namely, the alpha and beta forms of CaMKIV that differ only in that the beta form contains a 28 amino acid N-terminal extension as well as calspermin. Calspermin is the C-terminal 169 amino acids of CaMKIV that binds Ca2+/calmodulin and is expressed only in postmeiotic male germ cells. The promoter for calspermin resides in the penultimate intron of the CaMKIV gene and is regulated by two CREs. This promoter is sufficient to faithfully target expression of a reporter gene to the postmeiotic male germ cells of transgenic mice. Transgene expression can be induced in cells from the transgenic mice that do not normally express it by transfection of CREM tau and CaMKIV. These data suggest that rearrangement of chromatin during meiosis together with the expression of CREM tau at high levels are sufficient to control expression of the calspermin promoter during spermatogenesis. On the other hand, the developmental expression of CaMKIV in brain and thymus appears to be controlled by thyroid hormone mediated via the thyroid hormone receptor alpha. In T lymphocytes, CaMKIV will phosphorylate CREB in response to signals that result in T cell activation. Transgenic mice that express a kinase minus mutant of CaMKIV specifically in thymic T cells show a marked reduction of total thymic cellularity. The remaining T cells undergo a much greater than normal rate of spontaneous apoptosis when placed in culture. These cells fail to generate the signals to phosphorylate CREB and produce significantly less of the cytokine Interleukin-2 (IL-2) in response to agents that either increase intracellular Ca2+ and/or activate protein kinase C. Collectively, the data suggest that CaMKIV may be involved both in preventing apoptosis during T cell development and also in the early cascade of events that is required to activate the mature T cells in response to a mitogenic stimulus.
Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia (2011)

Abstract Tipifarnib (T) exhibits modest activity in elderly adults with newly diagnosed acute myelogenous leukemia (AML). Based on preclinical synergy, a phase 1 trial of T plus etoposide (E) yielded 25% complete remission (CR). We selected 2 comparable dose levels for a randomized phase 2 trial in 84 adults (age range, 70-90 years; median, 76 years) who were not candidates for conventional chemotherapy. Arm A (T 600 mg twice a day × 14 days, E 100 mg days 1-3 and 8-10) and arm B (T 400 mg twice a day × 14 days, E 200 mg days 1-3 and 8-10) yielded similar CR, but arm B had greater toxicity. Total CR was 25%, day 30 death rate 7%. A 2-gene signature of high RASGRP1 and low aprataxin (APTX) expression previously predicted for T response. Assays using blasts from a subset of 40 patients treated with T plus E on this study showed that AMLs with a RASGRP1/APTX ratio of more than 5.2 had a 78% CR rate and negative predictive value 87%. This ratio did not correlate with outcome in 41 patients treated with conventional chemotherapies. The next T-based clinical trials will test the ability of the 2-gene signature to enrich for T responders prospectively. This study is registered at www.clinicaltrials.gov as #NCT00602771.
Mobile App Retrieval for Social Media Users via Inference of Implicit Intent in Social Media Text (2016)

People often implicitly or explicitly express their needs in social media in the form of "user status text". Such text can be very useful for service providers and product manufacturers to proactively provide relevant services or products that satisfy people's immediate needs. In this paper, we study how to infer a user's intent based on the user's "status text" and retrieve relevant mobile apps that may satisfy the user's needs. We address this problem by framing it as a new entity retrieval task where the query is a user's status text and the entities to be retrieved are mobile apps. We first propose a novel approach that generates a new representation for each query. Our key idea is to leverage social media to build parallel corpora that contain implicit intention text and the corresponding explicit intention text. Specifically, we model various user intentions in social media text using topic models, and we predict user intention in a query that contains implicit intention. Then, we retrieve relevant mobile apps with the predicted user intention. We evaluate the mobile app retrieval task using a new data set we create. Experiment results indicate that the proposed model is effective and outperforms the state-of-the-art retrieval models.
57.1: <i>Invited Paper</i>: Flexible OLEDs for Lighting Applications (2012)

Abstract In this paper we will discuss the key technologies needed for fabricating flexible OLED lighting panels with specific focuses on flexible substrates, high efficacy phosphorescent materials and thin film encapsulation technologies. We will report results of 15 cm × 15 cm phosphorescent OLED (PHOLED™) flexible lighting panels using flexible substrates.
Low-band extension of telephone-band speech (2002)

This paper describes a system that generates a low-band signal (100-300 Hz) from a telephone-band (300-3400 Hz) speech signal to obtain an extended-band speech signal (100-3400 Hz). The low-band increases signal naturalness and listening comfort. This system is applied at the receiving end such that compatibility with all current telephone networks is maintained. The described technique splits the telephone-band speech signal into a spectral envelope and a short-term residual. The spectral envelope and the residual are extended separately and recombined to create an extended band signal. This system is evaluated by listening tests and distortion measurement.
High temperature mechanical properties of a zirconium-modified, precipitation- strengthened nickel, 30 percent copper alloy (1974)

A precipitation-strengthened Monel-type alloy has been developed through minor alloying additions of zirconium to a base Ni-30Cu alloy. The results of this exploratory study indicate that thermomechanical processing of a solution-treated Ni-30Cu-0.2Zr alloy produced a dispersion of precipitates. The precipitates have been tentatively identified as a Ni5Zr compound. A comparison of the mechanical properties, as determined by testing in air, of the zirconium-modified alloy to those of a Ni-30Cu alloy reveals that the precipitation-strengthened alloy has improved tensile properties to 1200 K and improved stress-rupture properties to 1100 K. The oxidation characteristics of the modified alloy appeared to be equivalent to those of the base Ni-30Cu alloy.
In Situ Measurement of pH Under High Pressure (2010)

In situ measurement of pH under high pressure is complicated by the need to remain functional under extreme pressures, electrically noisy environments, and the difficulty in inferring chemical equilibrium conditions under pressure. We describe a pH sensor wherein the current flowing at a given input voltage is directly related to hydrogen ion concentration and can be operated within extreme environments. The sensor was tested at 25 °C for in situ pH measurement of several buffer solutions under high pressure up to 784.6 MPa. We found generally an increase in the acidity of the buffer solutions with increasing pressure. In all cases, pH changes were found to be less than predicted using inferred reaction volume data from the literature. Sensor response and pH changes were found to be completely reversible upon depressurization at the same temperature.
Erbium-doped phosphate glass fibre amplifiers withgain per unit length of 2.1 dB/cm (1999)

Singlemode high erbium-doped phosphate glass fibres have been designed and fabricated. Gain measurements in a 2.15 cm fibre with an Er3+ concentration of 3.7 × 1020 cm–3 were performed. A net gain of 2.1 dB/cm at 1537 nm was demonstrated with a pump diode power of 110 mW at 980 nm.