gebhart/patrepeval huggingface dataset:
Managing Employee Compliance with Information Security Policies: The Critical Role of Top Management and Organizational Culture* (2012)

ABSTRACT We develop an individual behavioral model that integrates the role of top management and organizational culture into the theory of planned behavior in an attempt to better understand how top management can influence security compliance behavior of employees. Using survey data and structural equation modeling, we test hypotheses on the relationships among top management participation, organizational culture, and key determinants of employee compliance with information security policies. We find that top management participation in information security initiatives has significant direct and indirect influences on employees’ attitudes towards, subjective norm of, and perceived behavioral control over compliance with information security policies. We also find that the top management participation strongly influences organizational culture which in turn impacts employees’ attitudes towards and perceived behavioral control over compliance with information security policies. Furthermore, we find that the effects of top management participation and organizational culture on employee behavioral intentions are fully mediated by employee cognitive beliefs about compliance with information security policies. Our findings extend information security research literature by showing how top management can play a proactive role in shaping employee compliance behavior in addition to the deterrence oriented remedies advocated in the extant literature. Our findings also refine the theories about the role of organizational culture in shaping employee compliance behavior. Significant theoretical and practical implications of these findings are discussed.
Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (2005)

The native and posttranslationally modified globin chains in minor and major Hbs are unambiguously identified by MALDI-TOF MS. A minor Hb containing the carbamylated alpha- and the betaS-chain elutes at the same time as normal HbA2 (alpha2delta2) and thus leads to falsely increased HbA2 values in patients with HbS when blood is analyzed with PolyCAT A chromatography.
Targeting Chemokine Receptor CCR1 as a Potential Therapeutic Approach for Multiple Myeloma (2022)

Multiple myeloma is an incurable plasma B-cell malignancy with 5-year survival rates approximately 10-30% lower than other hematologic cancers. Treatment options include combination chemotherapy followed by autologous stem cell transplantation. However, not all patients are eligible for autologous stem cell transplantation, and current pharmacological agents are limited in their ability to reduce tumor burden and extend multiple myeloma remission times. The "chemokine network" is comprised of chemokines and their cognate receptors, and is a critical component of the normal bone microenvironment as well as the tumor microenvironment of multiple myeloma. Antagonists targeting chemokine-receptor 1 (CCR1) may provide a novel approach for treating multiple myeloma. <i>In vitro</i> CCR1 antagonists display a high degree of specificity, and in some cases signaling bias. <i>In vivo</i> studies have shown they can reduce tumor burden, minimize osteolytic bone damage, deter metastasis, and limit disease progression in multiple myeloma models. While multiple CCR1 antagonists have entered the drug pipeline, none have entered clinical trials for treatment of multiple myeloma. This review will discuss whether current CCR1 antagonists are a viable treatment option for multiple myeloma, and studies aimed at identifying which CCR1 antagonist(s) are most appropriate for this disease.
One-Dimensional Constitutive Behavior of Shape Memory Alloys: Thermomechanical Derivation with Non-Constant Material Functions and Redefined Martensite Internal Variable (1993)

A one-dimensional constitutive model for the thermomechanical behavior of shape memory alloys is developed based on previous work by Liang and Tanaka. An internal variable ap proach is used to derive a comprehensive constitutive law for shape memory alloy materials from first principles without the assumption of constant material functions. This constitutive law is of such a form that it is well suited to further practical engineering applications and calculations. A separation of the martensite fraction internal variable into temperature-induced and stress- induced parts is presented and justified, which then allows the derived constitutive law to accurately represent both the pseudoelastic and shape memory effects at all temperatures. Several numerical ex amples are given that illustrate the ability of the constitutive law to capture the unique thermome chanical behavior of shape memory alloys due to their internal phase transformations with stress and temperature.
Hepatitis C virus NS5A protein interacts with 2′,5′-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner (2004)

The non-structural protein 5A (NS5A) of hepatitis C virus (HCV) has been implicated in inhibition of antiviral activity of IFN. While previous studies have suggested an interaction between NS5A and the double-stranded RNA-dependent protein kinase (PKR), the possibility still remains that interaction with another molecule(s) is involved in the NS5A-mediated inhibition of IFN. In the present study, we investigated a possible interaction between NS5A and 2',5'-oligoadenylate synthetase (2-5AS), another key molecule in antiviral activity. We observed that NS5A physically interacted with 2-5AS in cultured cells, with an N-terminal portion of NS5A [aa 1-148; NS5A(1-148)] and two separate portions of 2-5AS (aa 52-104 and 184-275) being involved in the interaction. Single point mutations at residue 37 of NS5A affected the degree of the interaction with 2-5AS, with a Phe-to-Leu mutation (F37L) augmenting and a Phe-to-Asn mutation (F37N) diminishing it. Virus rescue assay revealed that the full-length NS5A (NS5A-F) and NS5A(1-148), the latter of which contains neither the IFN sensitivity-determining region (ISDR) nor the PKR-binding domain, significantly counteracted the antiviral activity of IFN. Introduction of a F37N mutation into NS5A(1-148) impaired the otherwise more significant IFN-inhibitory activity of NS5A(1-148). It was also found that the F37N mutation was highly disadvantageous for the replication of an HCV RNA replicon. Taken together, our results suggest the possibility that NS5A interacts with 2-5AS and inhibits the antiviral activity of IFN in an ISDR-independent manner.
Two Turntables and a Mobile Phone (2011)

A novel method of digital scratching is presented as an alternative to currently available digital hardware interfaces and time-coded vinyl (TCV). Similar to TCV, the proposed method leverages existing analog turntables as a physical interface to manipulate the playback of digital audio. To doso, however, an accelerometer/gyroscope–equipped smartphone is firmly attached to a modified record, placed on a turntable, and used to sense a performers movement, resulting in a wireless sensing-based scratching method. The accelerometer and gyroscope data is wirelessly transmitted to a computer to manipulate the digital audio playback in real-time. The method provides the benefit of digital audio and storage, requires minimal additional hardware, accommodates familiar proprioceptive feedback, and allows a single interface to control both digital and analog audio. In addition, the proposed method provides numerous additional benefits including real-time graphical display,multi-touch interaction, and untethered performance (e.g“air-scratching”). Such a method turns a vinyl record into an interactive surface and enhances traditional scratching performance by affording new and creative musical interactions. Informal testing show this approach to be viable,responsive, and robust.
Novel Protein Kinases Associated with Calcineurin B-Like Calcium Sensors in Arabidopsis (1999)

Jinrui Shi, Kyung-Nam Kim, Olga Ritz, Veronica Albrecht, Rajeev Gupta, Klaus Harter, Sheng Luan, , Novel Protein Kinases Associated with Calcineurin B-Like Calcium Sensors in Arabidopsis, The Plant Cell, Vol. 11, No. 12 (Dec., 1999), pp. 2393-2405
Prognostic Factors for Cutaneous and Subcutaneous Soft Tissue Sarcomas in Dogs (2010)

Soft tissue sarcomas (STSs) develop from mesenchymal cells of soft tissues, and they commonly occur in the skin and subcutis of the dog. Although phenotypically diverse with frequently controversial histogenesis, STSs are considered as a group because they have similar features microscopically and clinically. Following resection, local recurrence rates are low in general but vary according to histologic grade and completeness of surgical margins. Complete margins predict nonrecurrence. Even most grade I STSs with "close" margins will not recur, but propensity for recurrence increases with grade. The frequency of metastasis has not been accurately estimated, but it is believed to be rare for grade I STSs and most likely to occur with grade III STSs. However, metastasis does not necessarily equate with poor survival. High mitotic index is prognostic for reduced survival time. Further research is needed to determine more precise estimates for recurrence rates and survival as related to completeness of surgical margins and to delineate potential differences in metastatic rate and median survival time between grades. Other potential indicators of prognosis that presently require further investigation include histologic type, tumor dimension, location, invasiveness, stage, markers of cellular proliferation, and cytogenetic profiles. Common issues limiting prognostic factor evaluation include biases from retrospective studies, small sample sizes, poor verification of metastasis, inconsistent STS classification and use of nomenclature, difficulties in differentiating STS phenotype, and diversity of the study population (stage of disease and treatment status).
A multi-feature description scheme for image and video database retrieval (1999)

This paper reports about a description scheme for visual information content, which has been developed in the context of the forthcoming MPEG-7 standard. The system supports similarity-based retrieval of visual (image and video) data along feature axes like color, texture, shape/geometry and motion. The descriptors for these features have been developed in a way such that invariance against common transformations of visual material, e.g. filtering, contrast/color manipulation, resizing etc. is achieved, and that they are fitted to human perception properties. Furthermore, descriptors have been designed that allow a fast, hierarchical search procedure. A search engine has been developed on the basis of this description scheme, which allows similarity-based retrieval from an image or video database. The results show that efficient search and retrieval in visual database systems is possible based on a normative feature description such as MPEG-7.
Moment-tensor invariants: Searching for non-double-couple earthquakes (1990)

A method for assessing the presence of a non-double-couple component in seismic sources is presented. The equation for the principal values of the moment tensor is a cubic equation with coefficients which are polynomial combinations of the tensor components. These coefficients are invariants of the tensor that relate to its symmetry and do not depend on the coordinate system used to describe the source. Each coefficient has a physical interpretation: The constant coefficient is determined by how well one or two double-couples describe the source, and the quadratic coefficient is the volume change associated with the source. If volume change is assumed to be absent, the constant term represents a measure of the double-couple nature of the source. A seismic waveform inversion method is presented which exactly explores the range of values of these properties. The method of extremal models is used to determine minimum and maximum values of the invariants subject to the constraint that the data must be satisfied within prescribed errors. For the invariant associated with the source volume change, this constraint results in a linear programming problem and a global solution may be found. For the other invariants a nonlinear programming problem results which may be solved by a reduced gradient algorithm. Two events were examined: A deep earthquake from the Bonin Islands and the Harzer nuclear explosion. A double-couple mechanism is essentially compatible with the Bonin Islands waveforms. Models with a positive volume change were required to fit the Harzer data. Some variation in the mechanism is possible due to gaps in the station distribution and possibly due to significant scattering from lateral heterogeneities. However, in spite of a range in the isotropic component, the event could not be fit with a double-couple mechanism.
New tilted-poles Wien filter with enhanced performance (1989)

The Wien filter is an E×B deflecting analyzer with the electrostatic field perpendicular to the magnetostatic field. The twofold functions of the Wien filter are as an energy analyzer as well as a mass analyzer. It has very high resolution for paraxial charged-particle beams with V=E/B, the Wien velocity. Two Wien filters, a tilted-poles Wien filter, and a classical parallel-rectangular-poles Wien filter were built and tested for electrons up to 3.5 keV and protons beams of 200 eV. (The tilted-poles Wien filter is a new diagnostic developed by the authors.) The performance of the two is compared, and the tilted-poles Wien filter has superior resolution to the classical Wien filter. Both Wien filters appear to have features useful for high-temperature plasma diagnostics, including simultaneous measurement of energy and mass spectra, and high resolution.
Avalanche breakdown in <i>A</i> <i>l</i> <i>x</i> <i>G</i> <i>a</i>1−<i>x</i> <i>A</i> <i>s</i> alloys and <i>A</i> <i>l</i>0.3<i>G</i> <i>a</i> <b>0.7</b> <i>A</i> <i>s</i> <b>/</b> <i>G</i> <i>a</i> <i>A</i> <i>s</i> multilayers (1995)

The avalanche breakdown voltage (Vb) has been measured in a range of bulk AlxGa1−xAs alloys and Al0.3Ga0.7As/GaAs multilayer structures. The bulk alloys show a linear dependence of Vb on x up to at least x=0.6. Multilayers with thin (≤100 Å) dimensions follow this trend, with Vb being determined by the average Al fraction of the multilayer ‘‘pseudoalloy’’. For thicker (≥500 Å) layers Vb tends to a mean of the bulk values of the layers. The transition from pseudoalloy to bulklike behavior is interpreted in terms of the momentum and energy relaxation lengths, estimated for bulk GaAs using a Monte Carlo solution of the semiclassical transport equation.
Reproducing affective norms with lexical co-occurrence statistics: Predicting valence, arousal, and dominance (2014)

Human ratings of valence, arousal, and dominance are frequently used to study the cognitive mechanisms of emotional attention, word recognition, and numerous other phenomena in which emotions are hypothesized to play an important role. Collecting such norms from human raters is expensive and time consuming. As a result, affective norms are available for only a small number of English words, are not available for proper nouns in English, and are sparse in other languages. This paper investigated whether affective ratings can be predicted from length, contextual diversity, co-occurrences with words of known valence, and orthographic similarity to words of known valence, providing an algorithm for estimating affective ratings for larger and different datasets. Our bootstrapped ratings achieved correlations with human ratings on valence, arousal, and dominance that are on par with previously reported correlations across gender, age, education and language boundaries. We release these bootstrapped norms for 23,495 English words.
Targeting plasma membrane GRP78 for cancer growth inhibition (2010)

Commentary to:Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cellsUma K. Misra, and Salvatore V. Pizzo
Predicting the Thermodynamic Stability of Solids Combining Density Functional Theory and Machine Learning (2017)

We perform a large scale benchmark of machine learning methods for the prediction of the thermodynamic stability of solids. We start by constructing a data set that comprises density functional theory calculations of around 250000 cubic perovskite systems. This includes all possible perovskite and antiperovskite crystals that can be generated with elements from hydrogen to bismuth, excluding rare gases and lanthanides. Incidentally, these calculations already reveal a large number of systems (around 500) that are thermodynamically stable but that are not present in crystal structure databases. Moreover, some of these phases have unconventional compositions and define completely new families of perovskites. This data set is then used to train and test a series of machine learning algorithms to predict the energy distance to the convex hull of stability. In particular, we study the performance of ridge regression, random forests, extremely randomized trees (including adaptive boosting), and neural networks. We find that extremely randomized trees give the smallest mean absolute error of the distance to the convex hull (121 meV/atom) in the test set of 230000 perovskites, after being trained in 20000 samples. Surprisingly, the machine already works if we give it as sole input features the group and row in the periodic table of the three elements composing the perovskite. Moreover, we find that the prediction accuracy is not uniform across the periodic table, being worse for first-row elements and elements forming magnetic compounds. Our results suggest that machine learning can be used to speed up considerably (by at least a factor of 5) high-throughput DFT calculations, by restricting the space of relevant chemical compositions without degradation of the accuracy.
Multistage trellis coded quantisation (MS-TCQ) design and performance (1997)

Multistage trellis coded quantisation (MS-TCQ) is developed as a constrained trellis source coding technique for successive refinement of information. The authors study the performance of two-stage trellis coded quantisers for Gaussian and uniform memoryless sources. Problems of appropriate trellis selection, output alphabet selection, and stage-by-stage design of the codebooks are addressed. Stagewise optimisation is done using the generalised Lloyd algorithm. Comparisons with two-dimensional multistage vector quantisation (MSVQ) indicate that up to 1.6 dB performance improvement can be achieved by using MS-TCQ. Another algorithm is also presented for the joint design of the stage codebooks to optimise the overall performance. It is shown that another 0.5 dB improvement can be achieved by employing the joint design algorithm.
Iv administration of a water-insoluble antimitotic compound entrapped in liposomes. Preliminary report on infusion of large volumes of liposomes to man. (1983)

Five patients with advanced multiresistant neoplasms were infused with NSC-251635 (a water-insoluble antimitotic agent) entrapped in egg yolk lecithin, cholesterol, and stearylamine liposomes. The maximum volume injected was 400 ml containing 8 g of lipids, ie, a dose of 135 mg/kg of body weight. Overall tolerance of the treatment was excellent. This study indicates that liposomes may be used safely as carriers for the iv administration of water-insoluble drugs to humans.
Track Membrane Mediated Electrostatic Introduction of Cluster Ions into TOF Mass Spectrometer (1998)

Glycerol-wetted track membranes (poly(ethylene terephthalate)) are suitable for interfacing between a typical TOF chamber (held at an operational pressure of less than 10-6 Torr) and an ambient pressure analyte. Solute concentration aspects of track membrane mediated electrostatic introduction of negative charged species into TOF mass spectrometer were investigated. Glycerol solutions of KCl, KBr, NH4I, and Na2S were used. High-field charge extraction conditions were routinely maintained between the liquid samples (held at ambient pressure) and a grounded grid collector. The latter was positioned just nearby the vacuum facing side of such membranes. Upon establishing a steady-state charge extraction regime, the collector currents were monitored and recorded at various solute concentration levels. Nonlinear, solute concentration dependent, collector currents were observed and found to correspond to our theoretical treatment. Our findings are accounted for and in support of a special, evaporation limited, mechanism for the track membrane mediated high-field extraction of cluster ions.
Extended Time Dependent Dielectric Breakdown Model Based on Anomalous Gate Area Dependence of Lifetime in Ultra Thin Silicon Dioxides (1997)

The conventional time dependent dielectric breakdown (TDDB) model is extended for ultra thin silicon dioxides on the basis of the four stage dielectric breakdown process model (FSM), in which the dielectric breakdown process consists of two individual processes: the “partial breakdown” and the “complete breakdown”. The lifetime measured under constant voltage stressing shows an anomalous gate area dependence as predicted by the extended TDDB model. This model can be adopted not only for the ultra thin oxides but also for oxides where the partial breakdown takes place. The conventional TDDB model is regarded as a case in which the time to complete breakdown after the partial breakdown is ignored compared to the time to partial breakdown. Furthermore, it is demonstrated that one cannot obtain an accurate lifetime without taking into account the extended TDDB model.
Fraction of Multiphase Flow Measurement System Design and Application (2011)

This paper introduced the application of pattern recognition in the measuring phase fraction of gas-powder mixed flow. Flow-through measurement system based on virtual instrument techniques; include the techniques of electrical capacitance tomography and cross-correlation velocity measurement technology. The module structure of the system is present. According the principle of the phase fraction based on pattern recognition technology, the arithmetic with C++ program is described in the paper. The experiment process for this flow-through measurement system and experiment results are described in this article.
Bladder cancer (2010)

Progress continues in bladder cancer diagnosis and management, and we anticipate that future work will further advance the care of patients with this disease.
Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. (1994)

Diesel exhaust particles (DEP) have been implicated in the increased incidence of allergic airway disorders. We investigated the effects of DEP on localized immunoglobulin production by performing nasal challenges with varying doses of DEP and analyzing the local immune response in nasal lavages obtained before and after. A significant rise in nasal IgE but not IgG, IgA, IgM, or albumin was observed in subjects 4 d after challenge with 0.30 mg DEP, equivalent to exposure on an average Los Angeles day. Direct evidence for DEP-enhanced local production of IgE was that challenge increased the number of IgE-secreting cells in lavage fluid from < 1 in 2,000,000 to > 1 in 100,000 but did not alter the number of IgA-secreting cells. There was a concomitant increase in epsilon mRNA production in the lavage cells. Additionally, DEP altered the relative amounts of five different epsilon mRNAs generated by alternative splicing, mRNAs that code for different IgE proteins. These results show that DEP exposure in vivo causes both quantitative and qualitative changes in local IgE production. The implication is that natural exposure to DEP may result in increased expression of respiratory allergic disease.