gebhart/patrepeval huggingface dataset:
<i>N</i>-Tritioacetoxyphthalimide:  A New High Specific Activity Tritioacetylating Reagent (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTN-Tritioacetoxyphthalimide: A New High Specific Activity Tritioacetylating ReagentManouchehr Saljoughian, Hiromi Morimoto, Philip G. Williams, Chit Than, and Stephen J. SeligmanView Author Information National Tritium Labelling Facility, Structural Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, and Department of Medicine and Department of Anatomy and Cell Biology, Box 77, SUNY/Health Science Center, 450 Clarkson Avenue, Brooklyn, New York 11203 Cite this: J. Org. Chem. 1996, 61, 26, 9625–9628Publication Date (Web):December 27, 1996Publication History Received27 August 1996Published online27 December 1996Published inissue 1 January 1996https://doi.org/10.1021/jo9616522Copyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1057Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (124 KB) Get e-AlertscloseSUBJECTS:Chemical reactions,Hydrogen isotopes,Organic reactions,Peptides and proteins,Reagents Get e-Alerts
Development of a Hydrogen-Fueled Combustion Turbine Cycle for Power Generation (1997)

Consideration of a hydrogen based economy is attractive because it allows energy to be transported and stored at high densities and then transformed into useful work in pollution-free turbine or fuel cell conversion systems. Through its New Energy and Industrial Technology Development Organization (NEDO) the Japanese government is sponsoring the World Energy Network (WE-NET) Program. The program is a 28-year global effort to define and implement technologies needed for a hydrogen-based energy system. A critical part of this effort is the development of a hydrogen-fueled combustion turbine system to efficiently convert the chemical energy stored in hydrogen to electricity when the hydrogen is combusted with pure oxygen. The full-scale demonstration will be a greenfield power plant located sea-side. Hydrogen will be delivered to the site as a cryogenic liquid, and its cryogenic energy will be used to power an air liquefaction unit to produce pure oxygen. To meet the NEDO plant thermal cycle requirement of a minimum of 70.9%, low heating value (LHV), a variety of possible cycle configurations and working fluids have been investigated. This paper reports on the selection of the best cycle (a Rankine cycle), and the two levels of technology needed to support a near-term plant and a long-term plant. The combustion of pure hydrogen with pure hydrogen with pure oxygen results only in steam, thereby allowing for a direct-fired Rankine steam cycle. A near-term plant would require only moderate development to support the design of an advanced high pressure steam turbine and an advanced intermediate pressure steam turbine.
Comparison of single 1-day-old chick vaccination using a Newcastle disease virus vector with a prime/boost vaccination scheme against a highly pathogenic avian influenza H5N1 challenge (2013)

Avian influenza (AI) vaccines should be used as part of a whole comprehensive AI control programme. Vectored vaccines based on Newcastle disease virus (NDV) are very promising, but are so far licensed in only a few countries. In the present study, the immunogenicity and protection against a highly pathogenic H5N1 influenza challenge were evaluated after vaccination with an enterotropic NDV vector expressing an H5 haemagglutinin (rNDV-H5) in 1-day-old specific pathogen free chickens inoculated once, twice or once followed by a heterologous boost with an inactivated H5N9 vaccine (iH5N9). The heterologous prime/boost rNDV-H5/iH5N9 combination afforded the best level of protection against the H5N1 challenge performed at 6 weeks of age. Two rNDV-H5 administrations conferred a good level of protection after challenge, although only a cellular H5-specific response could be detected. Interestingly, a single administration of rNDV-H5 gave the same level of protection as the double administration but without any detectable H5-specific immune response. In contrast to AI immunity, a high humoral, mucosal and cellular NDV-specific immunity could be detected up to 6 weeks post vaccination after using the three different vaccination schedules. NDV-specific mucosal and cellular immune responses were slightly higher after double rNDV-H5 vaccination when compared with single inoculation. Finally, the heterologous prime/boost rNDV-H5/iH5N9 combination induced a broader detectable immunity including systemic, mucosal and cellular AI and NDV-specific responses.
Photoluminescence stabilization of anodically-oxidized porous silicon layers by chemical functionalization (2002)

Electrochemical oxidation of porous silicon (PSi) produces a surface that is covered with native silicon–hydrogen (Si–Hx) bonds and regions with oxidized Si–Si back-bonds (OSi–Hx). Such anodically oxidized PSi layers were chemically modified using 1-decene under thermal conditions. The hydrosilylation reaction consumes mainly the nonoxidized Si–Hx bonds and yields a surface with oxidized and alkylated regions that were characterized using transmission IR and Raman spectroscopies. The brightest photoluminescence (PL) was obtained when the PSi sample was anodized in 1 M sulfuric acid (H2SO4) at 3 mA/cm2 for 5 min. The chemical process preserves the PL and the physical properties of the porous layer. The derivatized PSi surfaces are stable in boiling CCl4 and in water.
Selective Ring Opening Cross Metathesis of Cyclooctadiene and Trisubstituted Cycloolefins (2001)

[reaction: see text] The selective ring opening cross metathesis of 1,5-cyclooctadiene and trisubstituted cycloolefins with acroyl species is described. The ring-opened products contain electronically differentiated olefins suitable for additional metathesis reactions. Trisubstituted cycloolefins open regioselectively, placing the acroyl cap on the less-substituted terminus.
Novel monolithic phase shifter combining ferroelectrics and high temperature superconductors (1994)

Abstract We describe a monolithic phase shifter which combines the low loss of high temperature superconductivity (HTS) with the variable dielectric properties of a ferroelectric material SrTiO3. Phase shifts greater than 28 degrees per wavelength were observed around 30 K. Benefits of the combination of HTS and ferroelectric materials are described. The compatibility of YBa2Cu3O7-x and other ferroelectric materials is discussed.
Molecular Mechanism of the Affinity Interactions between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations (2011)

Protein A (SpA) affinity chromatography has been widely used for the purification of immunoglobulin G (IgG). However, the molecular mechanism of the affinity between IgG and SpA remains unclear. In this work, molecular dynamics simulations and molecular mechanics-Poisson-Boltzmann surface area analysis were performed to investigate the molecular mechanism of the affinity interactions. It is found that hydrophobic interaction contributes more than 80% to the binding free energy, while electrostatic interaction plays a minor role (<20%). Through free energy decomposition and pair interaction analysis, the hot spots of the SpA-hIgG1 complex are identified. For hIgG1, the hot spots include the residues of I253, H310, Q311, D315, K317, E430, and N434. For SpA, residues F132, Y133, H137, E143, R146, and K154 contribute significantly. Furthermore, helix I of SpA binds Fc through hydrophobic interaction, while helix II mainly provides electrostatic interaction that determines the binding selectivity to different Igs. Finally, the binding motif of SpA is constructed, which would help design novel high-affinity ligands of IgG.
Combining Data Mining and Machine Learning for Effective Fraud Detection (1997)

This paper describes the automatic design of methods for detecting fraudulent behavior. Much of the design is accomplished using a series of machine learning methods. In particular, we combine data mining and constructive induction with more standard machine learning techniques to design methods for detecting fraudulent usage of cellular telephones based on profiling customer behavior. Specifically, we use a rulelearning program to uncover indicators of fraudulent behavior from a large database of cellular calls. These indicators are used to create profilers, which then serve as features to a system that combines evidence from multiple profilers to generate high-confidence alarms. Experiments indicate that this automatic approach performs nearly as well as the best hand-tuned methods for detecting fraud.
A New Assay Using Surface Plasmon Resonance (SPR) to Determine Binding of the<i>Lactobacillus acidophilus</i>Group to Human Colonic Mucin (2004)

A new binding assay to investigate the mechanism of adhesion of lactic acid bacteria to the human intestine was established by the surface plasmon resonance technique using a biosensor BIACORE1000. Cells of 26 strains of the Lactobacillus acidophilus group as analytes were eluted onto a sensor chip on which were immobilized biotinylated A-trisaccharide polymer probes having human A-type antigen [(GalNAcalpha1-3(Fucalpha1-2)Gal)-] or human colonic mucin of blood type A (HCM-A) as ligands. In the first screening, high adhesive affinity to the A-trisaccharide BP-probe was observed in L. acidophilus OLL2769, L. crispatus JCM8778, LA205 and LA206. In the second screening, which used HCM-A, only L. acidophilus OLL2769 and L. crispatus JCM8778 were selected as adhesive strains with specific binding ability to human A-antigen. The results indicated that some strains of the L. acidophilus group could recognize and bind the sugar chain of A-antigen structure on HCM.
Contactless Electrodeposition and Micropatterning Via Bipolar Electrochemical Printing (2013)

Abstract not Available.
Adhesive Properties of Cured Phenylethynyl-Terminated Imide Oligomers (1995)

Abstract As part of a program to develop structural adhesives for high performance aerospace applications, phenylethynyl-terminated imide oligomers are under evaluation. Imide oligomers with different molecular weights and compositions endcapped with either 4-(3-aminophenoxy)-4′-phenylethynylbenzophenone (3-APEB) or 4-phenylethynylphthalic anhydride (PEPA) have been prepared and characterized. These oligomers exhibit excellent processability. After heating to 350°C for 1 hour, the terminal phenylethynyl groups have reacted to provide chain extension, branching and crosslinking. The cured polymers exhibit excellent solvent resistance and high mechanical properties as neat resins and in various adhesive forms (tensile shear, sandwich flatwise tension and climbing drum peel specimens). The chemistry and properties of these phenylethynyl-terminated imide oligomers are discussed.
Tumor Necrosis Factor- α Negatively Regulates Airway Hyperresponsiveness through γδ T Cells (2001)

Abstract Tumor necrosis factor (TNF)- α is a potent cytokine with immunomodulatory, proinflammatory, and pathobiologic activities. Although TNF- α is thought to play a role in mediating airway inflammation and airway hyperresponsiveness (AHR), its function is not well defined. TNF- α –deficient mice and mice expressing TNF- α in their lungs because of a TNF- α transgene placed under the control of the surfactant protein (SP)-C promoter (SP-C/TNF- α –transgenic mice) were sensitized to ovalbumin (OVA) and subsequently challenged with OVA via the airways; airway function in response to inhaled methacholine was monitored. In the TNF- α –deficient mice, AHR was significantly increased over that in controls. In contrast, the transgenic mice failed to develop AHR. In addition, sensitized/ challenged TNF- α –deficient mice had significantly increased numbers of eosinophils and higher levels of interleukin (IL)-5 and IL-10 in their bronchoalveolar lavage fluid than were found for control mice. However, in SP-C/TNF- α –transgenic mice, both the numbers of eosinophils and levels of IL-5 and IL-10 were significantly lower than in sensitized/challenged transgene-negative mice. γδ T cells have been shown to be activated by TNF- α and to negatively regulate AHR. Depletion of γδ T cells in the TNF- α –transgenic mice in the present study increased AHR, whereas depletion of these cells had no significant effect in TNF- α –deficient mice. These data indicate that TNF- α can negatively modulate airway responsiveness, controlling airway function in allergen-induced AHR through the activation of γδ T cells.
Diffractive imaging micro-spectrometer (2006)

Optical multiplexers/demultiplexers developed for the telecommunication industry, at the level of the basic principles, 
perform essentially the same functions as general-use optical spectrometers. The spectrometer design inspired by the 
telecom devices would represent an extremely compact device compatible with the manufacturing procedures in 
integrated optoelectronics and micro-optics. In this paper we summarize our recent results on development of a 
miniature optical spectrometer. The spectrometer uses a diffractive optical element integrated with a planar optical 
waveguide. It is designed to provide spectral resolution of at least 2nm in the entire visible spectral range from 400nm-
700nm, and simultaneously resolve spectra from up to 35 independent optical inputs. The optical part of the 
spectrometer fits volume below 10mm3. The spectrometer is designed for on-chip diagnostic systems, in particular for 
fluorescence detection of hazardous materials. A device prototype with diffractive optical element fabricated using 
electron beam lithography is manufactured and tested.
Capacitive wireless powering for electric vehicles with near-field phased arrays (2017)

This work demonstrates a simple approach for mitigating the high fringing electromagnetic fields produced by high-frequency capacitive wireless powering of electric vehicles. A 6.78 MHz (ISM band) single module Capacitive Wireless Power Transfer (CWPT) system based on GaN on Si inverters and rectifiers provides an output power of 110W with an efficiency of 90%. The electric field produced by the single module is measured to be above the safety exposure limits provided by ICNIRP, consistent with previously reported CWPT. To reduce the E-field produced, while maintaining the required power transfer, a multimodule approach is introduced in which the separate modules are phased to provide a measured field reduction of over 24% and 43% for two and four module systems, respectively.
Lithium Ion Battery Materials as Tunable, Redox Non-Innocent Catalyst Supports (2021)

The development of general strategies for the electronic tuning of a catalyst’s active site is an ongoing challenge in heterogeneous catalysis. To this end we report the application of cathode and anode materials as redox non-innocent catalyst supports that can be continuously modulated as a function of lithium intercalation. A zero valent nickel complex was oxidatively grafted onto the surface of lithium manganese oxide (LixMn2O4) to yield single-sites of Ni2­+ (Ni/LixMn2O4). Its activity for olefin hydrogenation was found to be a function of the redox state of the support material, with the most lithiated variant showing the most activity. X-ray absorption, X-ray photoelectron, solid-state nuclear magnetic resonance and electron paramagnetic resonance spectroscopies, and electron microscopy techniques established the nature of the nickel species on LixMn2O4. Catalyst control through support redox non-innocence was extended to an organotantalum complex on lithium titanium oxide (LixTiO2), demonstrating the generality of this phenomenon.
Chemically Stable Multilayered Covalent Organic Nanosheets from Covalent Organic Frameworks via Mechanical Delamination (2013)

A series of five thermally and chemically stable functionalized covalent organic frameworks (COFs), namely, TpPa-NO2, TpPa-F4, TpBD-(NO2)2, TpBD-Me2, and TpBD-(OMe)2 were synthesized by employing the solvothermal aldehyde-amine Schiff base condensation reaction. In order to complete the series, previously reported TpPa-1, TpPa-2, and TpBD have also been synthesized, and altogether, eight COFs were fully characterized through powder X-ray diffraction (PXRD), Fourier transform IR (FT-IR) spectroscopy, (13)C solid-state NMR spectroscopy, and thermogravimetric analysis. These COFs are crystalline, permanently porous, and stable in boiling water, acid (9 N HCl), and base (3 N NaOH). The synthesized COFs (all eight) were successfully delaminated using a simple, safe, and environmentally friendly mechanical grinding route to transform into covalent organic nanosheets (CONs) and were well characterized via transmission electron microscopy and atomic force microscopy. Further PXRD and FT-IR analyses confirm that these CONs retain their structural integrity throughout the delamination process and also remain stable in aqueous, acidic, and basic media like the parent COFs. These exfoliated CONs have graphene-like layered morphology (delaminated layers), unlike the COFs from which they were synthesized.
Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II (2020)

Epithelial ovarian carcinoma (EOC) is the most prevalent and lethal form of ovarian cancer. The low five-year overall survival after EOC diagnosis indicates an urgent need for more effective ways to control this disease. Anti-Müllerian hormone receptor 2 (AMHR2) is an ovarian protein overexpressed in the majority of human EOCs. We have previously found that vaccination against the ovarian-specific extracellular domain of AMHR2 (AMHR2-ED) significantly inhibits growth of murine EOCs through an IgG-mediated mechanism that agonizes receptor signaling of a Bax/caspase-3 dependent proapoptotic cascade. To determine if a single monoclonal antibody (mAb) could inhibit growth of human EOC, we generated a panel of mAbs specific for recombinant human AMHR2-ED and characterized a candidate mAb for humanization and use in clinical trials. We found that our candidate 4D12G1 mAb is an IgG<sub>1</sub> that shows high affinity antigen-specific binding to the 7-mer <sup>20</sup>KTLGELL<sup>26</sup> sequence of AMHR2-ED that facilitates induction of programmed cell death in EOC cells. Most importantly, the 4D12G1 mAb significantly inhibits growth of primary human EOCs in patient-derived xenografts (PDXs) by inducing direct apoptosis of EOC tumors. Our results support the view that a humanized 4D12G1 mAb may be a much needed and effective reagent for passive immunotherapy of human EOC.
Use of 2-dimensional arrays to determine the uniformity of Josephson junctions (1993)

The linewidths of phase-locked, oscillating arrays of high temperature superconducting Josephson junctions have been used to estimate such statistical information for several junction processes using a fitting process to simulate results. Statistical data from arrays consisting of several hundred to many thousand junctions operating, and at least partially phase locked, at 77K are being used to characterize and improve junction processes. Spreads on critical currents for three different processes; step edge, edge SNS and electron-beam defined nanobridges, have ranged from +or-3% to 15% (l sigma ) and on normal state resistances from +or-2% to 11%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
First‐in‐human study with intratumoral administration of a CD40 agonistic antibody, ADC‐1013, in advanced solid malignancies (2019)

Agonistic CD40 antibodies activate dendritic cells and can expand and activate tumor-specific T cells. Our purpose was to assess the CD40 agonistic antibody ADC-1013 in the clinical setting including intratumoral administration since preclinical studies have indicated that intratumoral is better than intravenous administration. A Phase I, open label, multicenter study was conducted in patients with advanced solid tumors who had received established treatments. A modified 3 + 3 dose-escalation was applied (every other week dosing). Twenty-three patients were treated with ADC-1013 intratumorally (dosing from 22.5 μg/kg up to 400 μg/kg) or intravenously (dosing at 75 μg/kg). The pharmacodynamic effects observed in the patients were further verified in an hCD40tg mouse model. Adverse events were mostly Common Terminology Criteria for Adverse Events (CTCAE) Grades 1 or 2 and transient. The serum concentration ADC-1013 and cytokine release (MCP-1, TNFα and IL-6) were more pronounced in patients receiving injections in deep metastases compared to patients receiving injections in superficial metastases. Treatment with ADC-1013 resulted in a marked decrease in B cell levels in peripheral blood after 24 h while remaining B cells significantly increased their expression of the cell surface activation marker CD86. Activation of antigen-presenting cells and subsequent activation of T cells were demonstrated in hCD40tg mice. Moreover, ADC-1013 treatment in this mouse model acted synergistically with a PD-1 inhibitor. The results from the first-in-human study of ADC-1013 indicate that intratumoral administration of ADC-1013 into superficial lesions is well tolerated at clinically relevant doses and associated with pharmacodynamic responses.
Experimental Demonstration of Multi Moiré Structured Illumination Microscopy (2018)

Structured illumination microscopy (SIM) improves spatial resolution by folding high-frequency spectral components into the optical system’s passband. While linear SIM is superior in terms of temporal resolution, living-cells imaging compatibility, and overall optical setup simplicity relative to other super-resolution techniques, it is, however, inferior when it comes to spatial resolution enhancement capability. In this letter, we present experimental demonstration of a novel Multi Moiré SIM (MM-SIM) scheme achieving improved lateral resolution enhancement while preserving the inherent advantages of linear SIM. Using MM-SIM, an approximately 4-fold lateral resolution enhancement was achieved, effectively increasing the optical system’s NA from 0.4 to 1.6. The MM-SIM scheme is a simple and robust realization of 4-fold resolution enhancement capable of unleashing the full potential of standing-wave total internal reflection fluorescence structured illumination microscopy (TIRF-SIM) while preserving the inherent advantages of SIM.