gebhart/patrepeval huggingface dataset:
Antibodies from Chagas patients serum bind to the gut epithelial cell surface of Triatoma infestans. (1991)

Serum of chagasic patients with a high title of specific antibodies against T. cruzi antigens, binds epitopes in the midgut and hindgut of the insect vector Triatoma infestans free of parasites. These antigens were recognized at ultrastructural level by immunocytochemistry with serum of chagasic patients as first antibody and protein "A"-gold as marker. Controls with normal human serum were negative. The positive reaction occurs principally in the apical epithelial portion (microvilli and peritrophic membrane) of the midgut and in the cuticular layer and adjacent cytoplasm of the hindgut. In vectors infected with trypanosomes, the antigen-antibody reaction occurs similarly in the epithelium and also in the trypanosomes present in the lumen. These results suggest that there are antigenic factors in the vector gut that are incorporated by the parasite and are recognized by the immunitary system of the human patient with production of specific antibodies.
Reducing anchor loss in micromechanical extensional mode resonators (2010)

In this work, we propose a novel method to increase the quality factor of extensional mode micromechanical resonators. The proposed resonator topology is suitable for integration in a silicon-based process to fabricate micromechanical filters and oscillators. It is a half-wavelength-long strip excited longitudinally by electrostatic forces, and it is isolated from the substrate by alternating with bars of a quarter wavelength long. This structure causes a large impedance mismatch between the resonator and the substrate and hence reduces the anchor loss considerably. The performance of the resonator is determined by finite element simulations. We introduce an equivalent electrical circuit to predict the performance of the resonator. The electrical model gives results consistent with the finite element simulations. The proposed resonator is expected to have a very small anchor loss resulting in a very high Q.
Zoom Fatigue in the Age of COVID-19 (2022)

As the COVID-19 pandemic has impacted how institutions of higher education function, colleges and universities have shifted to remote learning and now rely heavily on the use of web conferencing tools, such as Zoom, WebEx, Adobe Connect, and others. As a result, educators are increasingly experiencing the effects of Zoom fatigue. The purpose of this article is to explore the videoconferencing fatigue that has emerged during the COVID-19 pandemic. The technostress model is used as the framework to provide strategies for recognizing and addressing videoconferencing fatigue.
The lives of hidden figures matter in computer science education (2022)

"I cannot work on what I cannot see…" ---Katherine Goble, Hidden Figures
Synthesis, Optical Resolution, and Stereochemical Properties of a Rationally Designed Chiral C–N Palladacycle (2014)

A novel racemic tertiary amine, 1-(2,5-diisopropylphenyl)-N,N-dimethylethanamine, was synthesized from 2,5-diisopropylbenzaldehyde via a multistep approach in high overall yield. The ortho palladation of this ligand was found to be sensitive to the reaction conditions and the palladating reagents employed. The metal complexation process could thus generate a cyclopalladated complex in high yield, lead to an unexpected N-demethylated amine palladium(II) complex, or both. Both products have been isolated and characterized crystallographically in the solid state and spectroscopically in solution. The racemic cyclopalladated complex could be efficiently resolved via the formation of (S)-prolinato derivatives. The absolute stereochemistries of the resolved diastereomeric complexes were determined by single-crystal X-ray crystallography in the solid state and by 1H–1H rotating frame Overhauser effect (ROESY) NMR spectroscopy in solution. An evaluation of the sterically hindered resolved cyclopalladated units as chiral auxiliaries was conducted in the endo-cycloaddition reaction between 3,4-dimethyl-1-phenylphosphole (DMPP) and ethyl vinyl ketone. The two expected phosphanorbornene adducts were generated with moderate stereoselectivity.
Design and fabrication of photonic crystal thin film photovoltaic cells (2010)

We present the integration of an absorbing planar photonic crystal within a thin film photovoltaic cell. The devices are based on a stack including a hydrogenated amorphous silicon P-i-N junction surrounded by TCO layers, with a back metallic contact. Optical simulations exhibit a significant increase of the integrated absorption in the 300-720nm wavelength range. The global electro-optical characteristics of such a new solar cell, and the impact of surface passivation, are also discussed. Carrier generation rate maps calculated by optical simulations are introduced as input data in a commercial electrical simulation software. The fabrication of such a device is finally addressed, with a specific focus on the use of low cost nanopatterning processes compatible with large areas.
ChemInform Abstract: Synthesis of Native Proteins by Chemical Ligation (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Efficient field emission from ZnO nanoneedle arrays (2003)

Well-aligned arrays of ZnO nanoneedles were fabricated using a simple vapor phase growth. The diameters of the nanoneedle tips are as small as several nanometers, which is highly in favor of the field emission. Field-emission measurements using the nanoneedle arrays as cathode showed emission current density as high as 2.4 mA/cm2 under the field of 7 V/μm, and a very low turn-on field of 2.4 V/μm. Such a high emission current density is attributed to the high aspect ratio of the nanoneedles. The high emission current density, high stability, and low turn-on field make the ZnO nanoneedle arrays one of the promising candidates for field-emission displays.
Phase I Study of Chimeric Antigen Receptor–Modified T Cells in Patients with EGFR-Positive Advanced Biliary Tract Cancers (2017)

<b>Purpose:</b> This study is an expanded and parallel clinical trial of EGFR-specific chimeric antigen receptor-engineered autologous T (CART) cell immunotherapy (NCT01869166) to assess the safety and activity of CART-EGFR cell therapy in EGFR-positive advanced unresectable, relapsed/metastatic biliary tract cancers (BTC).<b>Experimental Design:</b> Patients with EGFR-positive (>50%) advanced unresectable, relapsed/metastatic BTCs were enrolled. Well-produced CART-EGFR cells were infused in a manner of dose escalation after the conditioning treatment with nab-paclitaxel (100-250 mg/m<sup>2</sup>) and cyclophosphamide (15-35 mg/kg).<b>Results:</b> A total of 19 patients (14 cholangiocarcinomas and 5 gallbladder carcinomas) received one to three cycles of CART-EGFR cell infusion (median CART cell dose, 2.65 × 10<sup>6</sup>/kg; range, 0.8-4.1 × 10<sup>6</sup>/kg) within 6 months. The CART-EGFR cell infusion was tolerated, but 3 patients suffered grade ≥3 acute fever/chill. Grade 1/2 target-mediated toxicities including mucosal/cutaneous toxicities and acute pulmonary edema and grade ≥3 lymphopenia and thrombocytopenia related to the conditioning treatment were observed. Of 17 evaluable patients, 1 achieved complete response and 10 achieved stable disease. The median progression-free survival was 4 months (range, 2.5-22 months) from the first cycle of treatment. Analysis of data indicated that the enrichment of central memory T cells (Tcm) in the infused CART-EGFR cells improved the clinical outcome.<b>Conclusions:</b> The CART-EGFR cell immunotherapy was a safe and active strategy for EGFR-positive advanced BTCs. The enrichment of Tcm in the infused CART-EGFR cells could predict clinical response. <i>Clin Cancer Res; 24(6); 1277-86. ©2017 AACR</i><i>See related commentary by Kalos, p. 1246</i>.
TH‐C‐303A‐03: Real‐Time Motion Detection of Prostate Target During Volumetric Arc Therapy Using Onboard Imaging Devices (2009)

Purpose: To develop a real‐time prostate position monitoring technique for modern arc radiation therapy through novel usage of cine‐MV imaging together with as‐needed kV imaging. Methods and Materials: We divide the task of monitoring intrafraction prostate motion into two separate but related parts: (1) to detect potential target motion beyond a pre‐defined threshold and (2) to confirm whether it is beyond the threshold and how large the displacement is. By taking advantage of the gantry rotation during arc therapy, MV images from different viewing angles were used to stereoscopically evaluate the motion status of the prostate/marker and to allow us to detect potential over‐threshold displacement. If a potential over‐threshold event is detected by MV images, the onboard kV imager is turned on to confirm this through combined data from MV‐kV imaging. The position information acquired from combined MV‐kV data can be used as input for further motion management techniques. A Varian Trilogy linac with onboard kV imager was used to examine selected typical trajectories using a 4D motion phantom capable of moving in accordance with a pre‐programmed trajectory. Performance analysis of the proposed method has been done using 536 patient‐measured trajectories from 17 patients. Results: Prostate displacement beyond a set threshold (3mm) was detected for over 99.8% of the time with better than 1mm detection accuracy. Compared to other fluoroscopy‐based tracking techniques, kV usage is significantly reduced to on average of ∼15 times per arc delivery. Conclusions: Cine MV imaging during arc therapy provides a valuable tool for detecting non‐negligible intrafraction prostate motion with as‐needed low kV usage. Our motion detection method is distinguished from current motion monitoring techniques which seek to continuously and accurately localize a moving target. The proposed technique can be readily implemented with linacs equipped with EPID and onboard kV imaging devices.
Lumbar interbody fusion: techniques, indications and comparison of interbody fusion options including PLIF, TLIF, MI-TLIF, OLIF/ATP, LLIF and ALIF. (2015)

Degenerative disc and facet joint disease of the lumbar spine is common in the ageing population, and is one of the most frequent causes of disability. Lumbar spondylosis may result in mechanical back pain, radicular and claudicant symptoms, reduced mobility and poor quality of life. Surgical interbody fusion of degenerative levels is an effective treatment option to stabilize the painful motion segment, and may provide indirect decompression of the neural elements, restore lordosis and correct deformity. The surgical options for interbody fusion of the lumbar spine include: posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), minimally invasive transforaminal lumbar interbody fusion (MI-TLIF), oblique lumbar interbody fusion/anterior to psoas (OLIF/ATP), lateral lumbar interbody fusion (LLIF) and anterior lumbar interbody fusion (ALIF). The indications may include: discogenic/facetogenic low back pain, neurogenic claudication, radiculopathy due to foraminal stenosis, lumbar degenerative spinal deformity including symptomatic spondylolisthesis and degenerative scoliosis. In general, traditional posterior approaches are frequently used with acceptable fusion rates and low complication rates, however they are limited by thecal sac and nerve root retraction, along with iatrogenic injury to the paraspinal musculature and disruption of the posterior tension band. Minimally invasive (MIS) posterior approaches have evolved in an attempt to reduce approach related complications. Anterior approaches avoid the spinal canal, cauda equina and nerve roots, however have issues with approach related abdominal and vascular complications. In addition, lateral and OLIF techniques have potential risks to the lumbar plexus and psoas muscle. The present study aims firstly to comprehensively review the available literature and evidence for different lumbar interbody fusion (LIF) techniques. Secondly, we propose a set of recommendations and guidelines for the indications for interbody fusion options. Thirdly, this article provides a description of each approach, and illustrates the potential benefits and disadvantages of each technique with reference to indication and spine level performed.
Three-dimensional reconstruction of specular reflecting technical surfaces using structured light microscopy (2014)

In computer assisted quality control the three-dimensional reconstruction of technical surfaces is playing an ever more important role. Due to the demand on high measurement accuracy and data acquisition rates, structured light optical microscopy has become a valuable solution for the three-dimensional measurement of technical surfaces with high vertical and lateral resolution. However, the three-dimensional reconstruction of specular reflecting technical surfaces with very low surface-roughness and local slopes still remains a challenge to optical measurement principles. Furthermore the high data acquisition rates of current optical measurement systems depend on highly complex and expensive scanning-techniques making them impractical for inline quality control. In this paper we present a novel measurement principle based on a multi-pinhole structured light solution without moving parts which enables the threedimensional reconstruction of specular and diffuse reflecting technical surfaces. This measurement principle is based on multiple and parallel processed point-measurements. These point measurements are realized by spatially locating and analyzing the resulting Point Spread Function (PSF) in parallel for each point measurement. Analysis of the PSF is realized by pattern recognition and model-fitting algorithms accelerated by current Graphics-Processing-Unit (GPU) hardware to reach suitable measurement rates. Using the example of optical surfaces with very low surface-roughness we demonstrate the three-dimensional reconstruction of these surfaces by applying our measurement principle. Thereby we show that the resulting high measurement accuracy enables cost-efficient three-dimensional surface reconstruction suitable for inline quality control.
Optically pumped Ce:LaF_3 laser at 286 nm (1980)

Ultraviolet laser action has been obtained from a 5d–4f transition in Ce3+-doped LaF3. The 286-nm wavelength obtained is the shortest of any solid-state laser. The approximate potential tuning range is from 275 to 315 nm.
Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of <i>ASCL1</i> Gene Expression (2015)

The BET (bromodomain and extra-terminal) proteins bind acetylated histones and recruit protein complexes to promote transcription elongation. In hematologic cancers, BET proteins have been shown to regulate expression of MYC and other genes that are important to disease pathology. Pharmacologic inhibition of BET protein binding has been shown to inhibit tumor growth in MYC-dependent cancers, such as multiple myeloma. In this study, we demonstrate that small cell lung cancer (SCLC) cells are exquisitely sensitive to growth inhibition by the BET inhibitor JQ1. JQ1 treatment has no impact on MYC protein expression, but results in downregulation of the lineage-specific transcription factor ASCL1. SCLC cells that are sensitive to JQ1 are also sensitive to ASCL1 depletion by RNAi. Chromatin immunoprecipitation studies confirmed the binding of the BET protein BRD4 to the ASCL1 enhancer, and the ability of JQ1 to disrupt the interaction. The importance of ASCL1 as a potential driver oncogene in SCLC is further underscored by the observation that ASCL1 is overexpressed in >50% of SCLC specimens, an extent greater than that observed for other putative oncogenes (MYC, MYCN, and SOX2) previously implicated in SCLC. Our studies have provided a mechanistic basis for the sensitivity of SCLC to BET inhibition and a rationale for the clinical development of BET inhibitors in this disease with high unmet medical need.
A Highly Ordered Self-Assembled Monolayer Film of an Azobenzenealkanethiol on Au(111): Electrochemical Properties and Structural Characterization by Synchrotron in-Plane X-ray Diffraction, Atomic Force Microscopy, and Surface-Enhanced Raman Spectroscopy (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Highly Ordered Self-Assembled Monolayer Film of an Azobenzenealkanethiol on Au(111): Electrochemical Properties and Structural Characterization by Synchrotron in-Plane X-ray Diffraction, Atomic Force Microscopy, and Surface-Enhanced Raman SpectroscopyW. Brett Caldwell, Dean J. Campbell, Kaimin Chen, Brian R. Herr, Chad A. Mirkin, A. Malik, M. K. Durbin, P. Dutta, and K. G. HuangCite this: J. Am. Chem. Soc. 1995, 117, 22, 6071–6082Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/ja00127a021https://doi.org/10.1021/ja00127a021research-articleACS PublicationsRequest reuse permissionsArticle Views2609Altmetric-Citations204LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
A spectrally efficient CDMA overlay (2002)

The authors describe a scenario in which a direct-sequence spread-spectrum personal communications network is overlaid on top of an existing set of narrowband microwave users. An overlay of this type results in very efficient use of the RF spectrum, and is indicative of what needs to be done to relieve the spectral congestion at radio frequencies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Colloidal crystals formed by polymer brush-afforded fine particles (2010)

This review highlights the recent development of a new family of colloidal crystals. In this system, monodisperse fine particles grafted with a concentrated polymer brush layer are used as a building block for the crystallization. Unlike the previously known (soft and hard) colloidal crystals, the driving force of crystallization in the new system is a long-range repulsive (non-interpenetrating) interaction between the highly swollen concentrated brush layers. The crystallization concentration is situated between those of typical soft and hard systems. Hence this is termed a semisoft system. Advantages of semisoft colloidal crystal include controllability of interparticle distance and crystal structure by controlling the graft chain length and density, applicability of various particles, applicability of various monomers, and usability of various solvents and solvent mixtures.
DESIGN OF THE PROPOSED 250 MEV SUPERCONDUCTING CYCLOTRON MAGNET (2007)

VECC has proposed a project for the design and development of a 250 MeV superconducting proton cyclotron, which may be used in therapy. In this paper we describe the preliminary design calculations for the superconducting cyclotron magnet. Hard-edge approximation method has been adopted for finding the poletip geometry to meet the basic focusing requirements of the beam. The uniform-magnetization method has been applied to calculate the 3D magnetic field distribution due to saturated iron poletips, to verify the beam dynamical issues and optimize the poletip geometry. GM type closed cycle cryo-cooler technology is being considered for steady state liquefaction of evaporated helium gas from magnet cryostat.
Comparative analysis of the genomes of Rachiplusia ou and Autographa californica multiple nucleopolyhedroviruses (2003)

The Rachiplusia ou multiple nucleopolyhedrovirus (RoMNPV) is a variant of Autographa californica MNPV (AcMNPV) but is significantly more virulent against several major agricultural pests. The genome sequence of the R1 strain of RoMNPV was determined and compared to that of AcMNPV strain C6. The RoMNPV genome is approximately 131.5 kbp with a G+C content of 39.1 %. The homologous repeat regions (hrs) described for AcMNPV-C6 are present in RoMNPV-R1 but the hrs of RoMNPV have fewer palindromic repeats. The RoMNPV-R1 nucleotide sequence is almost completely collinear with the sequence of AcMNPV-C6 and contains homologues of 150 of the 155 ORFs described for AcMNPV-C6. Deletions, insertions and substitutions have resulted in the loss of homologues for AcMNPV ORFs ac2 (bro), ac3 (ctl), ac97, ac121 and ac140 from the RoMNPV genome. The average amino acid sequence identity between RoMNPV and AcMNPV ORFs is 96.1 % and there are differences in promoter motif composition for 23 of these ORFs. Maximum-likelihood analysis of selection pressures on AcMNPV and RoMNPV ORFs indicate that ORFs ro18/ac20-ac21 (arif-1) and ro135/ac143 (odv-e18) have undergone positive selection.
Characteristic of p-Type Junctionless Gate-All-Around Nanowire Transistor and Sensitivity Analysis (2013)

The characteristics and sensitivities of p-type junctionless (JL) gate-all-around (GAA) (JLGAA) nanowire transistors are demonstrated by simulating a 3-D quantum transport device with a view to their use in CMOS technology. The concentration of dopants in a p-type JL nanowire transistor is not as high as that in an n-type device owing to solid solubility of boron in silicon. However, we can use a midgap material as gate electrode to design an appropriate device threshold voltage. The p-type JLGAA transistor exhibits a favorable on/off current ratio and better short-channel characteristics than a conventional inversion-mode transistor with a GAA structure. Sensitivity analyses reveal that the channel thickness and random dopant fluctuation substantially affect the device performance in terms of threshold voltage ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> ), on current ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> ), and subthreshold slope because of the full depletion condition of the channel. The channel length and oxide thickness have less impact because the short-channel effect is well controlled.