gebhart/patrepeval huggingface dataset:
(3<i>R</i>,5<i>S</i>,7a<i>s</i>)-(3,5-Bis(4-fluorophenyl)tetrahydro-1<i>H</i>-oxazolo[3,4-<i>c</i>]oxazol-7a-yl)methanol, a Novel Neuroprotective Agent (2009)

Compounds that interact with microtubules, such as paclitaxel, have been shown to possess protective properties against beta-amyloid (Abeta) induced neurodegeneration associated with Alzheimer's disease. In this work, the novel agent (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol was investigated for effectiveness in protecting neurons against several toxic stimuli and its interaction with the microtubule network. Exposure of neuronal cultures to Abeta peptide in the presence of 5 nM (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol resulted in a 50% increase in survival. Neuronal cultures treated with other toxic stimuli such as staurosporine, thapsigargin, paraquat, and H(2)O(2) showed significantly enhanced survival in the presence of (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol. Microtubule binding and tubulin assembly studies revealed differences compared to paclitaxel but confirmed the interaction of (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol with microtubules. Furthermore, in vitro studies using bovine brain microvessel endothelial cells experiments suggest that (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol can readily cross the blood-brain barrier in a passive manner.
Realistic talking face animation with speech-induced head motion (2021)

The recent advancements on talking face generation from speech have mostly focused on lip synchronization, realistic facial movements like eye blinks, eye brow motions but do not generate meaningful head motions according to the speech. This results in a lack of realism, especially in long speech. A very few recent methods try to animate the head motions, but they mostly rely on a short driving head motion video. In general, the prediction of head motion is largely dependent upon the prosodic information of the speech at a current time window. In this paper, we propose a method for generating speech-driven realistic talking face animation which has speech-coherent head motions with accurate lip sync, natural eye-blink, and high fidelity texture. In particular, we propose an attention-based GAN network to identify the highly correlated audio with the speaker's head motion and learn the relationship between the prosodic information of the speech and the corresponding head motions. Experimental results show that our animations are significantly better in terms of output video quality, realism of head movements, lip sync, and eye-blinks when compared to state-of-the-art methods, both qualitatively and quantitatively. Moreover, our user study shows that our speech-coherent head motions make the animation more appealing to the users.
A camera-based system for tracking people in real time (1996)

This paper describes a system for real-time tracking of people in video sequences. The input to the system is live or recorded video data acquired by a stationary camera in an environment where the primary moving objects are people. The output consists of trajectories which give the spatio-temporal coordinates of individual persons as they move in the environment. The system uses a new model-based approach to object tracking. It identifies feature points in each video frame, matches feature points across frames to produce feature "paths", then groups short-lived and partially overlapping feature paths into longer living trajectories representing motion of individual persons. The path grouping is based on a novel model-based algorithm for motion clustering. The system runs on an SGI Indy workstation at an average rate of 14 frames a second. The system has numerous applications since various statistics and indicators of human activity can be derived from the motion trajectories. Examples of these indicators described in the paper include people counts, presence and time spent in a region, traffic density maps and directional traffic statistics.
Silicon-chip single and coupled coplanar transmission line measurements and model verification up to 50GHz (2007)

Silicon technology on-chip single and coupled coplanar transmission lines have been measured on wafer up to 50 GHz. De-embedding was performed using various methods including the L-2L technique [1,2] by measuring two transmission lines of original and double length. A novel approach has been used for the measurement of the coupled structures using conventional two port VNA. Results are investigated both in S-parameter format and in gamma-Zo format, and compared with EM solver and the parametric IBM coplanar T-line device models discussed elsewhere [3,4] which are available in IBM CMOS and SiGe technology design kits. A comparison with RC model shows the limits of RC model validity, in frequency domain.
Monolithic silicon optoelectronic devices for protein and DNA detection (2006)

A new class of miniaturized monolithic silicon optoelectronic transducers properly functionalized to biosensors is outlined. The devices are based on biofunctionalized optocoupler arrays made on silicon by employing mainstream silicon integrated circuit technology. The optocouplers consist of silicon avalanche diodes operating as light emitting devices self aligned to thin silicon nitride waveguides and silicon detectors. Bioanalytical results that demonstrate the efficiency of the device are provided and include protein and DNA detection. Label free determinations are also demonstrated. The optical microdevices are suitable for multianalyte portable bioanalytical microsystems and present unique advantages due to their monolithic optical detection and small size.
Development of DSP Based Network Echo Cancellers (2009)

Adaptive filtering is an important area of digital signal processing and is one of the main topics in the digital signal processing classrooms. Echo cancellation is a typical example used to introduce adaptive filtering algorithms. In this paper, filling the gap between the understanding of adaptive filtering theory and the knowledge and skills needed to build a practical echo canceller is attempted. The necessary knowledge and skills (such as algorithm design, implementation on DSP platforms, debugging, performance analysis and testing) for developing a high-performance network echo cancellers are covered.
Development of cryogenic prototyping for tissue engineering (2008)

A major challenge in tissue engineering has been the creation of scaffolds with controlled complex geometries. Rapid prototyping (RP) has the ability to produce complex three-dimensional structures with precise control of pore size, geometry and connectivity. In this paper, a novel technique utilising RP technology for the fabrication of tissue engineering scaffolds is presented. The main advantage of this cryogenic prototyping (CP) technique is the low operating temperatures which will allow the processing of temperature sensitive and bioactive components. Microstructure of CP Chitosan scaffolds fabricated can be controlled by processing parameters, such as the processing temperature. The macrostructure of the scaffolds is controlled by 3D computer aided design (CAD). In addition, in vitro studies with Chitosan CP scaffolds have shown that the scaffold designs are useful in promoting cell infiltration and alignment. Preliminary in vivo studies show encouraging results of cellular infiltration as well as vascularisation.
Magnetic Resonance Nanoparticle Probes for Cancer Imaging (2003)

Abstract The sections in this article are Introduction Magnetic Nanoparticle Contrast Agents Silica‐ or Dextran‐coated Iron Oxide Contrast Agents Magnetoferritin Magnetodendrimers and Magnetoliposomes New Type of Contrast Agent: Non‐hydrolytically Synthesized High Quality Iron Oxide Nanoparticles Iron Oxide Nanoparticles in Molecular MR Imaging Infarct and Inflammation Angiogenesis Apoptosis Gene Expression Cancer Imaging Summary and Outlook
Swirl Effects on Distributed Combustion for Near Zero Emission Gas Turbine Application (2010)

Previous investigations of Colorless Distributed Combustion (CDC) demonstrated significant improvement in combustor’s performance. CDC is characterized by high recirculation of product gases, fast mixing, spontaneous ignition and distributed reaction, leading to avoidance of hotspots and much lower NOx emissions. In this investigation, CDC is sought with focus on tailored mixture preparation before ignition using swirl and achieving distributed combustion for developing near zero emission combustion under gas turbine combustion conditions. Numerical and experimental investigations have been performed on a cylindrical combustor. Different fuel injection and hot gases exit arrangements have been considered. Air was injected tangentially to produce vortical structure in the flow and produce high swirl intensity. Results obtained show ultra low NO emissions (∼3 PPM) at high heat release intensity of 36 MW/m3-atm at an equivalence ratio (Φ) of 0.6. The role of premixed and diffusion combustion is also examined.
A ZVT-PWM single-stage PFC converter with an active snubber (2002)

A single-stage power factor correction converter with soft-switching is proposed in this paper. Besides the ZVT turn-on performance of the main switch, the converter has ZCS for the auxiliary switch with an active snubber. High frequency operation of the proposed converter makes the ac-dc power supply possible to be minimized in size and weight. A 50-W 500-kHz prototype has been built in the laboratory to experimentally verify the analysis.
Raccoon Poxvirus as a Mucosal Vaccine Vector for Domestic Cats (2003)

In the present study, we evaluated both the immunogenicity and safety of recombinant raccoon poxvirus (RCN) as a mucosal vaccine vector for domestic cats. RCN is an orthopoxvirus that was isolated from healthy raccoons and has been used experimentally as a vaccine vector for rabies and other antigens in a variety of species, including raccoons, skunks, foxes, bobcats, rabbits, domestic cats, piglets, sheep and non-human primates. We evaluated the antibody response induced by a recombinant RCN vaccine expressing the rabies-G glycoprotein (RCN/rabies-G) administered to cats by the oral (PO), intranasal (IN), conjunctival (CO) or intranasal/conjunctival (IN/CO) route (dose: 10 plaque forming units or PFU). The IN route, either alone or combined with the CO route, induced the highest rabies virus neutralizing antibody (RVNA) titers. The RVNA titers remained high when measured at six months post-vaccination, demonstrating that the recombinant vaccine administered via these routes is very efficient at inducing long-lasting immunity. A dose-response was observed following IN vaccination in cats. Doses of 10 PFU induced strong antibody responses in 4 of 5 animals [geometric mean titer: 3.2 (log)]. None of the animals vaccinated with 10 PFU developed detectable RVNA titers. In this study, RCN/rabies-G viral shedding was below detectable levels. Nasal, oral and fecal swabs collected from these cats were negative for RCN by both virus isolation and by nested-PCR. In addition, no horizontal transmission of the virus could be detected. Gang-housed sentinel animals for each group did not develop detectable anti-RVNA or -RCN antibodies. To study tissue tropism of recombinant raccoon poxvirus vaccines, a RCN that can express the lacZ gene (RCN/lacZ) was constructed. Expression of beta-galactosidase (beta-gal) was validated in vitro and in mice in vivo. Cats were vaccinated IN with 10 PFU of RCN/lacZ. No histopathological lesions were detected in any of the tissues collected from these cats at 1, 4, 7 and 15 days post-vaccination. In addition, no virus or beta-gal expression was detected in any of these tissues. Controls demonstrated that virus could be reisolated from nasal swabs immediately after administration of 10 PFU to cats. These results suggest that recombinant RCN vaccines undergo limited replication after intranasal administration in cats that is sufficient to elicit strong, long-lasting systemic antibody responses.
Testing aspheric surfaces using two-wavelength phase-shifting interferometry (1985)

Two-wavelength holography and phase-shifting interferometry are combined to measure the phase contours of deep wave fronts and surfaces, like those produced by aspheres, with a variable sensitivity. When interference fringes are very closely spaced, the phase data contain high frequencies where 2 π ambiguities cannot be resolved, and many fringes are likely to fall on a single detector element. To reduce the problem of averaging fringes in a single pixel, an array of pinholes is used to mask the detector array enabling point sampling of the single-wavelength fringes. In this technique, the phase of the wave front is calculated modulo 27 π using phase-shifting techniques at each of two visible wavelengths. The difference between these two phase sets is the phase of the wave front as it would be measured at a synthesized equivalent wavelength λ eq = λ 1 λ 2 /| λ 1 − λ 2 |, assuming that 2π ambiguities can be removed. The integrated two-wavelength data are used to correct the 27 π ambiguities in the single-wavelength data, which increases the measurement range and keeps single wavelength precision. This technique enables aspheric surfaces with hundreds of waves of optical path difference to be measured to λ /100 in the visible.
Complementary DNA cloning and expression of a newly recognized high molecular mass allergen Phl p 13 from timothy grass pollen (<i>Phleum pratense</i>) (2000)

The newly characterized allergen Phl p 13, which shows homology with polygalacturonases, is clearly different from the allergen designated as Phl p 4 and therefore the high molecular mass fraction is composed of at least two different allergens. A possible reason why this important allergen has not been detected until now is that Phl p 13 and Phl p 4 are hardly separable by one dimensional SDS-PAGE.
Low Complexity Algebraic (2003)

Abstract- We present a low complexity algorithm for designing algebraic codes that achieve the infor-mation theoretic capacity for the multicast problem on directed acyclic networks. These codes operate over field sizes which are significantly smaller than those previously known, leading to significantly lower design and implementation complexity, and network link usage. These codes can be extended for networks with cycles and delays, and for robustness properties. A network is represented by a directed graph Ei = ( V, E) with a vertex set V and edge set E. Multiple edges are allowed between vertices, and 6 is acyclic. A source node s E V gen-erating information at rate R, and a set of N receiver nodes R = { T I, r2,..., T N} C V, axe specified. Nodes are allowed to transmit on outgoing edges any causal function of information
Successful Treatment of Bovine Retained Placenta by Umbilical Cord Injection of Collagenase (1991)

Collagen in the uterus is rapidly degraded during early postpartum by enzyme collagenase. However, during placenta retention there is a persistence of type III collagen in the bovine placentome (Biol Reprod 43:229, 1990; Theriogenology 32:485, 1989).
The Malarial Metabolite Hemozoin and Its Potential Use as a Vaccine Adjuvant (2010)

Hemozoin, a bio-crystalline substance, is a hemin detoxification by-product of malaria parasites. The role of hemozoin crystals in host immune system modulation by malaria parasites, and how they interact with the immune system has been enigmatic. Here, we summarize recent progress in our understanding of how hemozoin might be interacting with the host immune system. In particular, the potential application of hemozoin crystals as an adjuvant may provide insights into the molecular mechanisms involved in immune responses to malarial infection and provide a rationale for the design of vaccines against malaria as well as other immunological disorders such as allergies.
Comparative performance analysis of time–frequency distributions for spectroscopic optical coherence tomography (2005)

The analysis of spectroscopic optical coherence tomography (SOCT) signals suffers the trade-off between time resolution and frequency resolution. Various joint time–frequency distributions (TFDs) can optimize this trade-off. Synthesized signals were generated and experimentally acquired data were obtained to compare and validate several different TFDs under different SOCT imaging schemes. Specific criteria were designed to quantify the TFD performance. We found that different SOCT imaging schemes require different optimal TFDs. Cohen’s class TFDs generate the most compact time–frequency (TF) analysis, while linear TFDs offer the most reliable TF analysis. In both cases, if some prior information is known, model-based TF analysis can improve the performance.
Curse of digital polar transmission: Precise delay alignment in amplitude and phase modulation paths (2008)

Radio transmitters using the polar scheme utilize a CO-ORDInate Calculator (CORDIC) to transform the often interpolated baseband data in Cartesian format to its polar equivalent. This non-linear transmission typically results in an increased bandwidth for amplitude and phase modulated signals. In case of digital implementation, each of these amplitude and phase/frequency modulation paths are realized using segmented modulators, with fine resolution achieved by techniques such as sigma-delta modulation. This paper first describes the structure of a digital polar transmitter. This is followed by a study on the impact of the increased bandwidth in the polar domain on the timing alignment accuracy requirements between the amplitude and phase modulation paths. Furthermore, for each high-resolution modulation path the timing accuracy between the integer and the sigma-delta fractional path split is also analyzed.
Efficacy and Safety of Intravenous Meloxicam in Patients With Moderate-to-Severe Pain Following Bunionectomy (2018)

Meloxicam IV doses of 30 mg provided effective pain relief when administered once daily by bolus injection to patients with moderate-to-severe pain following bunionectomy, and had an acceptable safety profile.
SU-E-CAMPUS-T-05: Quality Evaluation of An Automatic VMAT Planning Method for Head and Neck Cancer Cases (2013)

Purpose: To evaluate the dosimetric quality of an automatic volumetric-modulated arc therapy (VMAT) planning method for Head and Neck (HN) cancer cases. Methods: Eighteen HN cancer cases are planned automatically by 2-arc VMAT. An OAR DVH prediction model automatically generates OAR dose sparing objectives for each patient case based on the patient's anatomical features. The model is trained by prior clinical IMRT plans. In addition, a pre-determined planning template was used for all the cases which specify the arc angles, collimator angles, jaw setting, etc, as well as the optimization priority for each objective, based on past VMAT planning experience. The automatic VMAT planning process requires only one round of optimization for each case. The dosimetric parameters for each OAR and PTV from the VMAT plans are compared with those in clinical IMRT plans. Results: The means (standard deviation in parenthesis) of the dosimetric parameters in the automatically generated VMAT and the clinical IMRT plans are (in Gy): parotid D50%: VMAT: 25.8 (8.6), IMRT: 25.7 (12.8), oral cavity D50%: VMAT: 33.2 (8.5), IMRT: 31.6 (9.5), larynx D50%: VMAT: 27.6 (13.3), IMRT: 26.3 (14.5), spinal cord + 5mm D2%: VMAT: 34.9 (2.2), IMRT: 36.2 (4.5), Brainstem D2%: VMAT: 18.9 (5.9), IMRT: 20.7(5.9). The dosimetric parameters for the OARs in the VMAT and IMRT plans have no significant differences. The only statistically significant difference is the dose homogeneity of the boost PTV (p = 0.0006), which is 5.2 Gy in VMAT plans vs. 7.1 Gy in IMRT plans. Conclusion: The automatic VMAT planning method can generate plans with dosimetric quality comparable to clinical IMRT plans generated by an expert. This study suggests the DVH prediction models learned from IMRT planning experience can be utilized to generate dose sparing objectives for VMAT planning. Partly supported by NIH/NCI and a Varian master research grant.
Digital in-line holography of microspheres (2002)

We have used digital in-line holography (DIH) with numerical reconstruction to image micrometer-sized latex spheres as well as ferrimagnetic beads suspended in gelatin. We have examined in detail theoretically and experimentally the conditions necessary to achieve submicrometer resolution of holographic reconstructions. We found that both transparent and opaque particles could be imaged with a resolution that was limited only by the wavelength of the light used. Simple inspection of intensity profiles through a particle allowed an estimate to be made of the particle's three position coordinates within an accuracy of a few hundred nanometers. When the derivative of a second-order polynomial fitted to the intensity profiles was taken, the X, Y, Z position coordinates of particles could be determined within +/-50 nm. More-accurate positional resolution should be possible with the help of more-advanced computer averaging techniques. Because a single hologram can give information about a large collection of distributed particles, DIH offers the prospect of a powerful new tool for three-dimensional tracking of particles.
Textual Document Indexing and Retrieval via Knowledge Sources and Data Mining (2002)

We present a knowledge-based query expansion technique to improve document retrieval effectiveness. The general concept terms in a query are substituted by a set of specific concept terms used in the corpus that co-occur with the key query concept. Since the expanded query matches with the document index terms much better, experimental results reveal that such query expansion produces better retrieval effectiveness than the unexpanded ones.
River‐Bend Bank Protection by Submerged Vanes (1983)

It is shown, theoretically and by a physical model, that short, vertical, submerged vanes installed at incidence to the channel axis in the outer half of a river‐bend channel significantly reduce the secondary currents and the attendant undermining and high‐velocity attack of the outer bank. The effect of the vanes on the secondary flow is estimated by a simple torque calculation using the Kutta‐Joukowski theorem. A design relation for the vane spacing is derived by equating the torque, about the channel centroid, produced by the flow curvature to that resulting from the lateral force exerted on the vanes. The relation is verified in an idealized, physical model of a bend of the Sacramento River, California.
Clinical and Physiological Applications of Electrical Impedance Tomography (1994)

Biomedical applications of electrical impedance tomography: a critical review, D.S. Holder and B.H. Brown review of EIT systems available for medical use, Brian Brown an overview of image reconstruction, D.C. Barber in-vivo impedance images using sinusoidal current patterns, J.C. Newell, D. Isaacson, M. Cheney.