gebhart/patrepeval huggingface dataset:
RELATIONSHIP BETWEEN ACCELERATED PLETHYSMOGRAM, BLOOD PRESSURE AND ARTERIOLAR ELASTICITY (1992)

The relationship between arterial blood pressure and accelerated plethysmogram (APG) obtained by differentiating two times digital plethysmogram was studied in five healthy male university students. Finger arterial blood pressure was found to change by inflating the cuff of a sphygmomanometer placed on the upper arm followed by gradual deflation. APG and blood pressure were analyzed in the beat by beat mode. Room temperature was maintained at 23-24°C.The following results were obtained :1) Component“a”of APG became higher, and“b”and“e”components became increased with systolic blood pressure (SBP) .2) Component“a”of APG decreased, as did also“b”and“e”components with increase in diastolic blood pressure (DBP) and arteriolar elasticity.3) The two mechanisms for increase in SBP were increase in blood volume, and increase in peripheral resistance. The wave pattern of APG (A-G) changed from G to A by the former, and A to G by the latter.These findings clearly show the relationship between APG and arterial blood pressure depend on the particular mechanism involved. The simultaneous mesurement of APG and blood pressure may serve as a useful means for measuring peripheral hemodynamics.
[Study of resonance exchange collisions in cesium vapour by optical-optical double resonance spectroscopy]. (2006)

An experimental study of cesium resonance exchange collision, Cs(6P(3/2), v) + Cs(6S(1/2), v')-->Cs(6S(1/2), v) + Cs (6P(3/2), v'), was carried out. Populations of excited atoms that all have the same z component of velocity were produced by pumping a vapor with a narrow-band laser. A counterpropagating single-mode diode laser was used to probe the excited atom velocity distribution in the 6P(3/2)-->8S(1/2) transition. Fluorescence was monitored in the 8S(1/2)-->6P(3/2) transition. The magnitude of the thermalizinng effect of resonance exchange collisions was estimated by measuring the ratio of the intensity in the narrow features to that associated with the Doppler pedestals. The rate coefficient of 9.62 x 10(-7) cm3 x s(-1) for the resonance exchange collisions was yielded. This work demonstrates that, in a pure metal vapor, the thermalization of velocity-selected excited-atom distribution by the mechanism of resonance exchange can be three orders of magnitude greater than that from velocity-changing collisions.
Joint Topic Modeling and Factor Analysis of Textual Information and Graded Response Data (2013)

Modern machine learning methods are critical to the de-velopment of large-scale personalized learning systems that cater directly to the needs of individual learners. The re-cently developed SPARse Factor Analysis (SPARFA) frame-work provides a new statistical model and algorithms for machine learning-based learning analytics, which estimate a learner’s knowledge of the latent concepts underlying a domain, and content analytics, which estimate the relation-ships among a collection of questions and the latent con-cepts. SPARFA estimates these quantities given only the binary-valued graded responses to a collection of questions. In order to better interpret the estimated latent concepts, SPARFA relies on a post-processing step that utilizes user-defined tags (e.g., topics or keywords) available for each question. In this paper, we relax the need for user-defined tags by extending SPARFA to jointly process both graded learner responses and the text of each question and its asso-ciated answer(s) or other feedback. Our purely data-driven approach (i) enhances the interpretability of the estimated latent concepts without the need of explicitly generating a set of tags or performing a post-processing step, (ii) improves the prediction performance of SPARFA, and (iii) scales to large test/assessments where human annotation would prove burdensome. We demonstrate the efficacy of the proposed approach on two real educational datasets.
Makeup Creativity Enhancement with an Augmented Reality Face Makeup System (2018)

This study presents a novel interactive face makeup system that aims to support users to improve makeup creativity. In this system, facial feature points were tracked by Kinect and mapped to the 3D face model. The makeup tools were developed for providing a tangible interaction. A face painting application was developed based on the Unity 3D framework. While users apply makeup, the program will generate color on the model, which synchronizes with the user's movement. The results will be mapped to the user's face in real time by using a projection mapping technique that allows users to see which color is suitable for their skin tone. Users can perceive a realistic makeup feeling from our touch detectable makeup tools. Moreover, by using a computer-based drawing system, users can undo, save, and load their makeup image and compare with other styles. A subjective evaluation was conducted to evaluate the users’ satisfaction. The results indicated that by using this system, users can find a suitable makeup style for themselves and get help increasing their makeup creativity.
Chronic hepatitis B virus infection and risk of chronic kidney disease: a population-based prospective cohort study of 0.5 million Chinese adults (2018)

Abstract Background Existing evidence remains inconclusive as to the association between chronic hepatitis B virus (HBV) infection and the risk of chronic kidney disease (CKD). We prospectively examined the association between chronic HBV infection and CKD risk, and the joint associations of HBV infection with established risk factors of several lifestyle factors and prevalent diseases on CKD risk. Methods Participants from the China Kadoorie Biobank were enrolled during 2004–2008 and followed up until 31 December 2015. After excluding participants with previously diagnosed CKD, cancer, heart disease, and stroke at baseline, the present study included 469,459 participants. Hepatitis B surface antigen (HBsAg) was qualitatively tested at baseline. Incident CKD cases were identified mainly through the health insurance system and disease and death registries. Results During a median follow-up of 9.1 years (4.2 million person-years), we documented 4555 incident cases of CKD. Cox regression yielded multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Compared with HBsAg-negative participants, the multivariable-adjusted HR (95% CI) for CKD was 1.37 (1.18, 1.60) for HBsAg-positive participants. The association was stronger in men (HR = 1.77; 95% CI: 1.43, 2.20) than in women (HR = 1.10; 95% CI: 0.88, 1.36). HBsAg-positive participants, with or without hepatitis or cirrhosis, whether or not under treatment, all showed increased risk of developing CKD. We observed positive additive interactions of HBsAg positivity with smoking, physical inactivity, or diabetes on CKD risk. Compared with HBsAg-negative participants who were nonsmokers, more physically active, or did not have diabetes at baseline, the greatest CKD risk for HBsAg-positive participants was for those who were smokers (HR = 1.85; 95% CI: 1.44, 2.38), physically inactive (HR = 1.91; 95% CI: 1.52, 2.40), or diabetic (HR = 6.11; 95% CI: 4.47, 8.36). Conclusions In countries with a high endemicity of HBV infection, kidney damage associated with chronic HBV infection should be a non-negligible concern. Our findings also highlight the importance of health advice on quitting smoking, increasing physical activity, improving glucose control, and early screening for CKD in people with chronic HBV infection.
Mutations in haemophilia A (1993)

In the present study DNA from 281 unrelated haemophilia A patients including 15 inhibitor patients has been analysed by Southern blotting technique. Using various restriction enzymes, cloned factor VIII cDNA probes and genomic fragments we have identified 14 mutations. Six of the mutations are novel partial factor VIII gene deletions. One deletion affects exon 1, two deletions concern exon 6, another deletion, of which breakpoints are sequenced, takes part of exon 16 and two deletions affect exon 26. Besides the deletions, eight point mutations have been found at the TaqI restriction sites of exons 18, 24 and 26. Five C-->T mutations resulted in nonsense mutations, one in exon 18, one in exon 26 and three in exon 24. Two G-->A mutations caused a missense mutation in exon 24 leading to an arginine/glutamine exchange. Although two patients showed this mutation, their clinical phenotypes were different, possibly due to an additional unidentified sequence polymorphism. A G-->T mutation in exon 26 substituted the arginine with leucine. All deletions and seven of the point mutations are associated with severe disease with a detectable inhibitor in the patient with the TaqI-point mutation in exon 18. One of the G-->A mutations is associated with mild haemophilia but the patient also has developed an inhibitor. Amongst these mutations the origin of the mutation could be determined in four kindred, one of which showed maternal mosaicism.
Effects of climate data aggregation on regional NPP modelling (2016)

Stream B: Methods in Environmental Modelling including optimization, sensitivity, uncertainty issues, model development and modelling frameworks<br/>Stream B: Methods in Environmental Modelling including optimization, sensitivity, uncertainty issues, model development and modelling frameworks
Wertorientiertes Controlling für forschende Pharmaunternehmen (2001)

Month by month, Controlling - Zeitschrift für erfolgsorientierte Unternehmenssteuerung publishes peer-reviewed, applied research contributions for business management, accounting and reporting. Key elements of succesful corporate controlling are presented in an analytic, well-structured manner.
Dating Texts without Explicit Temporal Cues (2012)

This paper tackles temporal resolution of documents, such as determining when a document is about or when it was written, based only on its text. We apply techniques from information retrieval that predict dates via language models over a discretized timeline. Unlike most previous works, we rely {\it solely} on temporal cues implicit in the text. We consider both document-likelihood and divergence based techniques and several smoothing methods for both of them. Our best model predicts the mid-point of individuals' lives with a median of 22 and mean error of 36 years for Wikipedia biographies from 3800 B.C. to the present day. We also show that this approach works well when training on such biographies and predicting dates both for non-biographical Wikipedia pages about specific years (500 B.C. to 2010 A.D.) and for publication dates of short stories (1798 to 2008). Together, our work shows that, even in absence of temporal extraction resources, it is possible to achieve remarkable temporal locality across a diverse set of texts.
Pure and Nd3+-, Pr3+-Ion Doped Trigonal Acentric LaBGeO5 Single Crystals Nonlinear Optical Properties, Raman Scattering, Spectroscopy, Crystal-Field Analysis, and Simulated Emission of Their Activators (1991)

Complex spectral investigations are made on new Nd3+- and Pr3+-doped and pure nonlinear-laser trigonal LaBGeO5 crystals. Raman spectra and nonlinear optical properties are studied including second harmonic generation, absorption, and luminescence spectra, which allow to determine the energy of Stark levels of the activator ions, luminescence-intensity characteristics, and pulse stimulated-emission parameters of Nd3+ ions at two intermanifold 4F3/2 → 4I11/2 and 4F3/2 →4I13/2 channels as well as of Pr3+ ions at the visible 3P0 → 3H6 transition. A preliminary theoretical analysis is made of the crystal field at activator ions using a new many-electron semiempirical method. All registered induced transitions are identified. LaBGeO5:Nd3+ is shown as a promising material for self-frequency doubled laser. [Russian Text Ignored.]
Brownian friction of gas molecules on the graphite surface (1999)

A calculation of the Brownian phononic friction coefficient of an isolated adatom on a crystal surface is formulated and then performed for Kr and ${\mathrm{N}}_{2}$ molecules on the {0001} graphite surface. The fluctuating forces on the adatom are expressed in terms of the normal modes of vibration of the substrate atoms. Then, the force autocorrelation functions and friction coefficients are calculated. The graphite phonon frequencies and polarization vectors are calculated for a thick slab using a generalized bond-charge model. There is a strong spatial dependence of the friction coefficient.
Templated Self-Assembly of Square Symmetry Arrays from an ABC Triblock Terpolymer (2009)

Self-assembly provides the ability to create well-controlled nanostructures with electronic or chemical functionality and enables the synthesis of a wide range of useful devices. Diblock copolymers self-assemble into periodic arrays of microdomains with feature sizes of typically 10-50 nm, and have been used to make a wide range of devices such as silicon capacitors and transistors, photonic crystals, and patterned magnetic media(1-3). However, the cylindrical or spherical microdomains in diblock copolymers generally form close-packed structures with hexagonal symmetry, limiting their device applications. Here we demonstrate self-assembly of square-symmetry patterns from a triblock terpolymer in which one organometallic block imparts high etch selectivity and etch resistance. Long-range order is imposed on the microdomain arrays by self-assembly on topographical substrates, and the orientation of both square lattices and in-plane cylinders is controlled by the substrate chemistry. Pattern transfer is demonstrated by making an array of square-packed 30 nm tall, 20 nm diameter silica pillars. Templated self-assembly of triblock terpolymers can generate nanostructures with geometries that are unattainable from diblock copolymers, significantly enhancing the capabilities of block copolymer lithography.
Efficacy of milciclib (PHA-848125AC), a pan-cyclin d-dependent kinase inhibitor, in two phase II studies with thymic carcinoma (TC) and B3 thymoma (B3T) patients. (2018)

8519 Background: Thymic carcinoma (TC) and B3 thymoma (B3T) are rare malignant tumors of the thymus. While TC, a highly aggressive and easily metastasizing cancer, has a very poor prognosis, B3T is a slow-growing cancer. Milciclib, a pan inhibitor of cyclin D-dependent kinases, Src and other kinases, exhibits antitumor activity against a number of solid tumors. Objectives of these studies were to evaluate efficacy and safety of oral treatment with milciclib in TC/B3T patients (pts). Methods: Two separate phase 2 multi-centered clinical trials (CDKO-125A-006: 72 pts, previously treated with one chemotherapy and CDKO-125A-007: 30 pts, previously treated with multiple chemotherapies) were conducted in the USA, France, and Italy. The proportion of patients with B3T and TC were 27.8% and 72.2% (CDKO-125a-006) and 56.7% and 43.3% (CDKO-125a-007), respectively. Milciclib was orally administered (150 mg daily; 1 cycle is 7d on/7d off) for multiple cycles. Progression-Free Survival rate at 3 months (PFS-3) was the primary endpoint. Results: Oral treatment with milciclib met PFS-3 as primary endpoint and OS as a secondary endpoint in both phase 2 trials. Five pts in CDKO-125A-006 and 2 in CDKO-125A-007 continued with treatment over 2 years and 2 of them over 5 years. 46.1% of pts in both studies experienced at least one AE. Common Grade 3-4 hematological and other toxicities were neutropenia (8.4%), creatinine, amylase, lipase increase (5.6%), nausea and asthenia (8.3%). The AEs leading to discontinuation were 12.7% for both studies. Clinical trial information: NCT01011439 and NCT01301391. Conclusions: Oral treatment with milciclib was safe and well-tolerated and met primary and secondary endpoints, achieving disease stabilization in a majority of TC/B3T patients. Treatment Efficacy CDKO-125a-006 CDKO-125a-007 Primary endpoint: PFS-3 > 17% evaluable pts Primary endpoint: PFS-3 > 40% evaluable pts Evaluable (n = 54) Treated (N = 72) Evaluable (N = 24) Treated (N = 30) PFS-3 (%) 44.4 41.7 54.2 46.7 Median PFS (mos) 6.83 5.78 9.76 5.65 Median OS (mos) 24.18 24.44 Not reached 21.03 Stable Disease (SD) ((%) 72.2 68.1 79.2 66.7 DCR (CR+PR+SD) (%) 75.9 72.2 83.3 70.0 ORR (%) 3.7 4.2 4.2 3.3
Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice (2015)

A major etiological risk factor for hepatocellular carcinoma (HCC) is infection by Hepatitis viruses, especially hepatitis B virus and hepatitis C virus. Hepatitis B virus and hepatitis C virus do not cause aggressive activation of an oncogenic pathway, but they transactivate a broad array of genes, cause chronic inflammation, and, through interference with mitotic processes, lead to mitotic error-induced chromosome instability (ME-CIN). However, how ME-CIN is involved in the development of HCC remains unclear. Delineating the effect of ME-CIN on HCC development should help in identifying measures to combat HCC. In this study, we used ME-CIN model mice haploinsufficient in Shugoshin 1 (Sgo1−/+) to assess the role of ME-CIN in HCC development. Treatment with the carcinogen azoxymethane caused Sgo1−/+ ME-CIN model mice to develop HCCs within 6 months, whereas control mice developed no HCC (P < 0.003). The HCC development was associated with expression of early HCC markers (glutamine synthetase, glypican 3, heat shock protein 70, and the serum marker alpha fetoprotein), although without fibrosis. ME-CIN preceded the expression of HCC markers, suggesting that ME-CIN is an important early event in HCC development. In 12-month-old untreated Sgo1 mice, persistent DNA damage, altered gene expression, and spontaneous HCCs were observed. Sgo1 protein accumulated in response to DNA damage in vitro. Overall, Sgo1−/+-mediated ME-CIN strongly promoted/progressed development of HCC in the presence of an initiator carcinogen, and it had a mild initiator effect by itself. Use of the ME-CIN model mice should help in identifying drugs to counteract the effects of ME-CIN and should accelerate anti-HCC drug development.
Familial Occurrence of Epilepsy in Children with Newly Diagnosed Multiple Seizures: Dutch Study of Epilepsy in Childhood (1998)

In 10% of children with newly diagnosed epilepsy, the condition is familial. Relatively more often, these children have generalized epilepsy syndromes as compared with children with a negative family history. Most of the relatives with idiopathic or cryptogenic epilepsy had the same seizure type as the proband. These findings confirm the role of genetic factors in the pathogenesis of epilepsy.
Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies (2003)

Regional expression of cytokines (IL-1alpha, TNF-alpha), inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS) was immunohistochemically investigated in the brains of patients with dementia with Lewy bodies (DLB), compared with those of patients with Alzheimer's disease (AD) and non-demented elderly persons. It has been reported that inflammatory responses by cytokines and oxygen free radicals such as nitric oxide (NO) are associated with damaged neurons, degenerative neurites or amyloid deposits in AD brains. In the present study, overexpression of IL-1alpha, TNF-alpha and iNOS was demonstrated in the amygdala, hippocampus, entorhinal and insular cortices of DLB brains, which are pathologically the most vulnerable regions in DLB brains as well as AD brains. In addition, some Lewy body (LB)-bearing neurons were involved by the processes of IL-1alpha- and TNF-alpha-positive microglia, and most extracellular LB were associated with the processes of TNF-alpha- and iNOS-positive astroglia. Glial involvement was also found around neuritic plaques and extracellular neurofibrillary tangles. In contrast, the expression of nNOS was reduced in the amygdala of DLB brains showing severe Lewy pathology. These findings suggest that cytokines and NO are significantly implicated in neuronal damage and death including LB formation in DLB brains.
High-field mobility effects in reoxidized nitrided oxide (ONO) transistors (1992)

The high-field mobility behavior of silicon MOSFETs fabricated with reoxidized nitrided oxide (ONO) gate dielectrics has been investigated. Measurements have been performed at both room temperature and 77 K on both n- an p-channel FETs, for both ONO and conventional SiO/sub 2/ films. While the peak electron mobility is much higher for standard SiO/sub 2/, a crossover occurs in the high-field region beyond which ONO transistors exhibit higher mobility. The crossover voltage is reduced at 77 K. Measurements intended to gain further insight into this phenomenon suggest that differences in surface roughness scattering, or the buried-channel nature of an ONO NMOS transistor, are the most likely explanations for the high-field mobility behavior observed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thermomechanical Aspects of high frequency cycling in salt storage caverns . (2011)

International audience
Nrf2: A Potential Target for New Therapeutics in Liver Disease (2012)

Nuclear erythroid 2-related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases-nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug-induced liver injury-and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression.
Efficient MAP approximation for dense energy functions (2006)

We present an efficient method for maximizing energy functions with first and second order potentials, suitable for MAP labeling estimation problems that arise in undirected graphical models. Our approach is to relax the integer constraints on the solution in two steps. First we efficiently obtain the relaxed global optimum following a procedure similar to the iterative power method for finding the largest eigenvector of a matrix. Next, we map the relaxed optimum on a simplex and show that the new energy obtained has a certain optimal bound. Starting from this energy we follow an efficient coordinate ascent procedure that is guaranteed to increase the energy at every step and converge to a solution that obeys the initial integral constraints. We also present a sufficient condition for ascent procedures that guarantees the increase in energy at every step.
On Backoff Timer Scheduling for Smart-DCF and Performance Evaluation (2008)

In this work, we present a generic backoff-timer scheduling algorithm for the Smart-DCF scheme. In Smart-DCF, the master station schedules the backoff timer value for each client station, and the backoff timer information is sent to the client station via an acknowledgment frame. The proposed backoff-timer scheduling mechanism enables the Smart-DCF access point to provide differentiated services to different classes of wireless stations or traffic. The simulation results demonstrate that the proposed scheduling algorithm is effective. The results also show that the Smart-DCF scheme noticeably outperforms the existing DCF scheme. In addition, the throughput performance of Smart-DCF starts to reach the saturated level when each data burst is longer than 5 frames.