gebhart/patrepeval huggingface dataset:
Charting a Manifold (2002)

this paper we use m i ( j ) N ( j ; i , s ), with the scale parameter s specifying the expected size of a neighborhood on the manifold in sample space. A reasonable choice is s = r/2, so that 2erf(2) &gt; 99.5% of the density of m i ( j ) is contained in the area around y i where the manifold is expected to be locally linear. With uniform p i and i , m i ( j ) and fixed, the MAP estimates of the GMM covariances are S i = m i ( j ) (y j i )(y j i ) # + ( j i )( j i ) # +S j m i ( j ) . (3) Note that each covariance S i is dependent on all other S j . The MAP estimators for all covariances can be arranged into a set of fully constrained linear equations and solved exactly for their mutually optimal values. This key step brings nonlocal information about the manifold&apos;s shape into the local description of each neighborhood, ensuring that adjoining neighborhoods have similar covariances and small angles between their respective subspaces. Even if a local subset of data points are dense in a direction perpendicular to the manifold, the prior encourages the local chart to orient parallel to the manifold as part of a globally optimal solution, protecting against a pathology noted in [8]. Equation (3) is easily adapted to give a reduced number of charts and/or charts centered on local centroids. 4 Connecting the charts We now build a connection for set of charts specified as an arbitrary nondegenerate GMM. A GMM gives a soft partitioning of the dataset into neighborhoods of mean k and covariance S k . The optimal variance-preserving low-dimensional coordinate system for each neighborhood derives from its weighted principal component analysis, which is exactly specified by the eigenvectors of its covariance matrix: Eigendecompose V k L k V # k S k with...
A New Structure of Universal Motor Using Soft Magnetic Composites (2004)

The universal or ac commutator motor, widely used in hand tools and domestic appliances generally uses a two-pole stator with a concentrated winding and an armature with interlocked coils elements. The copper volume and the axial length of the end windings of such conventional structures are then usually very important. In this paper, the authors present a new universal motor structure based on an efficient use of the isotropic magnetic properties of the soft magnetic composites and on the concentrated winding technique. The stator core presents a claw-pole structure and the armature has a concentrated winding with several coils wound around the same tooth. With this new ac commutator motor structure, a reduction of the total volume by a ratio equal to 200% is obtained when compared to a classical universal motor structure with nearly identical performance.
5PM: Secure Pattern Matching. (2012)

Abstract. In this paper we consider the problem of secure pattern matching that allows singlecharacter wildcards and substring matching in the malicious (stand-alone) setting. Our protocol, called 5PM, is executed between two parties: Server, holding a text of length n, and Client, holding a pattern of length m to be matched against the text, where our notion of matching is more general and includes non-binary alphabets, non-binary Hamming distance and non-binary substring matching. 5PM is the first secure expressive pattern matching protocol designed to optimize round complexity by carefully specifying the entire protocol round by round. In the malicious model, 5PM requires O((m + n)k 2) bandwidth and O(m + n) encryptions, where m is the pattern length and n is the text length. Further, 5PM can hide pattern size with no asymptotic additional costs in either computation or bandwidth. Finally, 5PM requires only two rounds of communication in the honest-but-curious model and eight rounds in the malicious model. Our techniques reduce pattern matching and generalized Hamming distance problems to a novel linear algebra formulation that allows for generic solutions based on any additively homomorphic encryption. We believe our efficient algebraic techniques are of independent interest. 1
High- reliability nonconductive adhesives for flip chip interconnections (2002)

Non-conductive adhesives (NCA) are one of the interconnection materials widely used in display packaging and flip chip packaging technology, especially for fine-pitch interconnection. NCA interconnection in flip chip assembly has many advantages such as easier processing, good electrical performance, lower cost, and low temperature processing. We have developed new NCA materials, film type, for flip chip assembly on organic substrate such as FR-4 printed circuit boards (PCBs). NCAs are generally mixture of epoxy polymer resin without any fillers. As a result, NCAs have higher CTE values than conventional underfill materials used to enhance thermal cycling reliability of solder flip chip assembly on FR-4 boards. In order to reduce thermal and mechanical stress and strain induced by CTE mismatch between a chip and organic substrate, the CTE of NCAs was lowered by filling of nonconductive fillers of diameter below 1 gm. The modified NCA in flip chip interconnection between gold stud bumps of a chip and metal pads of PCB substrates show highly reliable interconnection when exposed to various environmental tests, such as thermal cycling test (-55/spl deg/C/+160/spl deg/C, 1000 cycle), high temperature humidity test (85/spl deg/C/85%RH, 1000 hours) and high temperature storage test (125/spl deg/C, dry condition).
Self-Sustained Micromechanical Oscillator with Linear Feedback (2016)

Autonomous oscillators, such as clocks and lasers, produce periodic signals without any external frequency reference. In order to sustain stable periodic motion, there needs to be an external energy supply as well as nonlinearity built into the oscillator to regulate the amplitude. Usually, nonlinearity is provided by the sustaining feedback mechanism, which also supplies energy, whereas the constituent resonator that determines the output frequency stays linear. Here, we propose a new self-sustaining scheme that relies on the nonlinearity originating from the resonator itself to limit the oscillation amplitude, while the feedback remains linear. We introduce a model for describing the working principle of the self-sustained oscillations and validate it with experiments performed on a nonlinear microelectromechanical oscillator.
β-driven threshold elements (2002)

Circuits on threshold elements have aroused considerable interest in recent years. One of the possible approaches of their implementation is using output wired CMOS inverters. The model of such an element is a CMOS pair with variable /spl beta/ of fully open p- and n-transistors. This model is specified by the ratio form of threshold function. It has been proved that any threshold function can be rewritten in ratio form. This gives us an evident way of /spl beta/-driven implementation of threshold functions. It has the following differences from implementation on output wired CMOS invertors: -/spl beta/DTE requires one transistor per weight unit rather than two; -the implementability of /spl beta/DTE depends only on threshold value, not on the input weights sum. The analysis of /spl beta/DTE implementability, examples of circuits and results of their SPICE simulation are given.
Structure-activity relationships of novel 3-acylpyrrole derivatives: New inhibitors of platelet aggregation. (1980)

Several N-substituted-3-acyl-2, 5-dimethyl pyrrole derivatives were examined for their potency to inhibit aggregation of platelets in vitro and extra vivo in guinea pigs. A structure-activity relationship study showed that the substitution at 3 position of the pyrrole ring affected in vitro activity of inhibiting platelet aggregation. Compounds with 3-benzoyl or 3-thenoyl substituent had greater potency than those with 3-aliphatic acyl substituent. Modification of benzoyl, such as para substitution of phenyl group or reduction of carbonyl group, decreased the activity. There was no clear correlation between that N-substitution of the pyrrole ring and in vitro anti-platelet activity. However, compounds with a longer alkyl chain in the N-substituent had weaker activity. The in vitro inhibitory activity on prostaglandin synthetase of these compounds, though less potent compared with their antiplatelet activity, has a close correlation with the latter. N-substituents of the pyrrole ring had the effect on extra vivo activity. Compounds which have no N-alpha-methyl group and no hetero atoms such as oxygen or sulfur in the N-substituent diminished the extra vivo activity.
Connection splitting: an efficient way of reducing call blocking in ATM (2000)

In this paper, we propose a technique for reducing asynchronous transfer mode (ATM) call blocking which is achieved by splitting wide-band connections into multiple low-bandwidth subconnections and routing them independently through the network. The essence of the mechanism is to use fragmented network bandwidth for supporting calls which are otherwise blocked by conventional routing. ATM bandwidth fragmentation may take place in a situation when a connection occupies a part of a link bandwidth and the rest of it is not sufficient for another connection. The unused bandwidth becomes fragmented. We provide a detailed cell-level design for the split-scheduling algorithms, which use a special type of ATM resource management cell for maintaining cell ordering. The analysis and simulation of the scheduling algorithms show that connection splitting is capable of delivering acceptable cell-level quality of service to multiple traffic classes. We also deliver a solution for implementing splitting without requiring any protocol changes within the network. We show that it is sufficient to modify the data and control plane protocols only within the end stations. Finally, a set of routing-level simulations for splitting demonstrates that splitting can reduce blocking by up to 45% for high-bandwidth calls in a moderately loaded network. Considering that it does not incur any network expenses or protocol changes, we propose splitting as an efficient means for reducing connection blocking.
The case in favour of probiotics before, during and after pregnancy: insights from the first 1,500 days (2016)

Successful human reproduction requires microbial homeostasis in the female reproductive tract, and colonisation of the newborn with beneficial microbes. In order to prevent several complications associated with dysbiosis, the administration of probiotics is more often being considered. The objective of the enclosed review was to examine the rationale for probiotic utility before and during pregnancy and in the early phase of infant life. The conclusions emerged from a panel of researchers who met during the International Scientific Association for Probiotics and Prebiotics (ISAPP) workshop held in Washington, DC, USA in 2015. The group concluded based upon the current literature, that a case can be made for the use of a specific sets of probiotic organisms during the first 1,500 days of life, with the goal of a healthy pregnancy to term, and a healthy start to life with lowered risk of infections and inflammatory events. The key to successfully translating these recommendations to practice is that products be made available and affordable to women in developed and developing countries.
An attempt for coloring multichannel MR imaging data (2001)

This is an elementary research into assigning color values to voxels of multi-channel magnetic resonance imaging (MRI) volume data. The MRI volume data sets obtained under different scanning conditions are transformed into components by independent component analysis (ICA), which enhances the physical characteristics of the tissue. The transfer functions for generating color values from the independent components are obtained by using a radial basis function network, a kind of neural net, by training the network with sample data chosen from the Visible Human female data set (VHF). The resultant color volume data sets correspond well with the full-color cross-sections of the Visible Human data sets.
Rhizobium japonicum USDA 191 has two nodD genes that differ in primary structure and function (1988)

Several Rhizobium genes (designated nod genes) are involved in early steps in nodule formation. Here we present the results of DNA sequence and functional analysis of two nodD genes from the symbiotic plasmid of USDA 191, a fast-growing strain that forms nitrogen-fixing nodules on soybeans. Both genes encoded full-length nodD-related polypeptides, which were 69% homologous to each other. One of these genes, nodD1, complemented a Rhizobium trifolii nodD::Tn5 mutant for clover nodulation; the other gene, nodD2, did not. The nodD1 coding region was preceded by a conserved DNA sequence previously noted in other rhizobia, but no such sequence was found in front of nodD2. Plants inoculated with a nodD1 insertion mutant appeared to be nitrogen starved and had a greatly reduced nodule number. Plants inoculated with a nodD2 mutant had a partially nitrogen-starved appearance and normal nodule number, were slightly delayed in nodule formation, and formed nodules that contained reduced levels of nodulin-35 and had fewer bacteroids per infected plant cell. Thus, both of these genes are involved in symbiosis. USDA 191 carrying extra copies of nodD2 on a plasmid vector had an altered colony morphology that suggested inhibition of exopolysaccharide synthesis. The predicted gene products of nodD1 and nodD2 both showed homology to LysR, an E. coli regulatory protein. We conclude that nodD1 probably has the same function as nodD in temperate rhizobia, namely, activation of nodABC transcription in the presence of plant signals. nodD2 may be involved in regulation of exopolysaccharide synthetic genes.
A service-oriented Cloud-based management system for the Internet-of-Drones (2017)

Deploying drones over the Cloud is an emerging research area motivated by the emergence of Cloud Robotics and the Internet-of-Drones (IoD) paradigms. This paper contributes to IoD and to the deployment of drones over the cloud. It presents, Dronemap Planner, an innovative service-oriented cloud based drone management system that provides access to drones through web services (SOAP and REST), schedule missions and promotes collaboration between drones. A modular cloud proxy server was developed; it acts as a moderator between drones and users. Communication between drones, users and the Dronemap Planner cloud is provided through the MAVLink protocol, which is supported by commodity drones. To demonstrate the effectiveness of Dronemap Planner, we implemented and validated it using simulated and real MAVLink-enabled drones, and deployed it on a public cloud server. Experimental results show that Dronemap Planner is efficient in virtualizing the access to drones over the Internet, and provides developers with appropriate APIs to easily program drones' applications.
Improved therapeutic efficacy via magnetite nanoconjugates derived synchronization of hyperthermochemotherapy (2012)

A novel nanoconjugate enabled synchronization of localized hyperthermia and drug release was presented. The hyperthermia was induced by the radiofrequency (RF) at 1.3MHz to trigger the release of 5-fluouracil (5-FU) anti-cancer drugs from magnetite nanocrystals core by breaking their hydrogen bond with the polynucleotide polymer carrier. The anti-Human Epidermal Growth Factor Receptor 2 (anti-HER2) antibody was end-modified on the polyethylene glycol to achieve cancer cell specific targeting and biological stealth. The 22 nm-sized magnetites displayed high saturation magnetization (94 emu/g) comparable to bulk magnetite (92 emu/g). The local regional heat triggers synchronized drug release and physical thermal damage of the cancer cells and significantly improved the anti-cancer efficacy in both in vitro and in vivo models than hyperthermia or chemotherapy alone as evidenced by cell viability assays and pathological examines. Complete remission of the disease in vivo was achieved through radiofrequency synchronization of hyperthermia and chemotherapy after intravenous injection of the nanoconjugates.
Chromatic dispersion measurements using a virtually referenced interferometer (2012)

We present a technique for measuring the chromatic dispersion of short-length (<1 m) optical devices using unbalanced spectral interferometry and a virtual reference path. The technique combines the speed and ease of measurement of unbalanced spectral interferometry with the accuracy of balanced spectral interferometry. We demonstrate measurement accuracy for group delay and the dispersion-length product of ~10(-3) ps/m (<0.0001% relative error) and ~10(-5) ps/m (<0.5% relative error), respectively. Measurement precision is demonstrated to be ~10(-5) ps/m (<0.15% relative deviation). We validate the technique via measurement of well-known dispersion standards.
Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support (1983)

An efficient procedure is described for synthesizing deoxyribonucleoside methylphosphonates on polystyrene polymer supports which involves condensing 5'-dimethoxytrityldeoxynucleoside 3'-methylphosphonates. The oligomers are removed from the support and the base protecting groups hydrolyzed by treatment with ethylenediamine in ethanol, which avoids hydrolysis of the methylphosphonate linkages. Two types of oligomers were synthesized: those containing only methylphosphonate linkages, d-Np(Np)nN, and those which terminate with a 5' nucleotide residue, dNp (Np)nN. The latter oligomers can be phosphorylated by polynucleotide kinase, and are separated by polyacrylamide gel electrophoresis according to their chain length. Piperdine randomly cleaves the oligomer methylphosphonate linkages and generates a series of shorter oligomers whose number corresponds to the length of the original oligomer. Apurinic sites introduced by acid treatment spontaneously hydrolyze to give oligomers which terminate with free 3' and 5' OH groups. These reactions may be used to characterize the oligomers.
High Velocity Pulsed Plasma Thermal Spray (2000)

Abstract The quality and durability of coatings produced by virtually all thermal spray techniques could be improved by increasing the velocity with which coating particles impact the substrate. Additionally, better control of the chemical and thermal environment seen by the particles during flight is crucial to the quality of the coating. A high velocity thermal spray device is under development through a BMDO SBIR project which provides significantly higher impact velocity for accelerated particles than is currently available with existing thermal spray devices. This device utilizes a pulsed plasma as the accelerative medium for powders introduced into the barrel. Recent experiments using a Control-Vision diagnostic system showed that the device can accelerate stainless steel and WC-Co powders to velocities ranging from 1500 to 2200 m/s. These high velocities are accomplished without the use of combustible gases, and without the need of a vacuum chamber, while maintaining an inert atmosphere for the particles during acceleration. The high velocities corresponded well to modeling predictions, and these same models suggest that velocities as high as 3000 m/s or higher are possible.
Polymerization of lactams, 27. Effect of reaction conditions on the anionic polymerization of 2‐pyrrolidone (part 4) (1978)

Abstract The effect of initiator and activator concentration on the course of the activated anionic polymerization of 2‐pyrrolidone was investigated. Potassium tert‐butoxide and N‐benzoylpyrrolidone, respectively, were used as polymerization initiator and activator. The course of the polymerization process was discussed on the basis of the polymer yield, molecular weight, and the content of basic groups in the polymer. The conversion dependences were presented in the form of an empirical mathematical equation.
Structural Modifications to the Internal Oligoguanidinium Transporter Uncover Two Potent Analogues that Effectively Deliver the Proapoptotic Peptide in Multiple Cancer Cell Lines (2021)

Efficient cytosolic delivery with serum-independent kinetics and low toxicity are the ultimate challenges towards the transformation of an antisense oligonucleotide or a therapeutic peptide to a suitable drug candidate for clinical trials. Most delivery vehicles falter on at least one of the above requirements, which hinders their potential in <i>in vivo</i> models as well. Our previous reports on internal guanidinium transporters (IGTs) have established the diversity of this particular class of molecule with the efficient delivery of antisense phosphorodiamidate morpholino oligonucleotides. In this paper, we report twenty IGTs with different types of evidence-backed structural modifications with different types of head-group linkage <b>R</b>, which significantly change the transfection, toxicity, and endosomal escape. Based on these three criteria, the analogues were sorted systematically to find the more promising IGTs, which were then further examined by LysoTracker studies. Finally, two analogues, with cholesteryl linkage (<b>R = Chol</b>) and pentafluorobenzyl linkage (<b>R = PF Cbz</b>), were selected for a proapoptotic peptide delivery as the final validation using a long-chain di-acid linker conjugation. Detailed mechanistic studies also revealed that the primary pathway of endocytosis is macropinocytosis, and that other pathways play different roles depending on the head group of the IGT. Since endocytosis pathways for entry depend on the nature of the cell line, we have shown the mechanistic variations in two cell lines for validation.
Piezoresistive Ring-Shaped AFM Sensors with Pico-Newton Force Resolution (2013)

A new concept of Atomic Force Microscope (AFM) oscillating probes using electrostatic excitation and piezoresistive detection is presented. The probe is characterized by electrical methods in a vacuum chamber and by mechanical methods in air. The frequency-mixing measurement technique is developed to reduce the parasitic signal level. These probes resonant in the 1MHz range and the quality factor is measured about 53000 in vacuum and 3000 in air. The ring probe is mounted onto a commercial AFM set-up and the surface topography of PMMA sample (2 µm square) is obtained. The force resolution deduced from the measurements is about 10 pN/Hz0.5.
Recovering scalable spin locks (2002)

We present a mechanism for making a scalable spin lock protocol, the MCS lock recoverable, thereby ensuring that a lock never becomes permanently unavailable, even if one or more processes using the lock die. This is achieved by modifying the original protocol to write additional information to shared memory and introducing a cleanup process which returns locks to a usable state in case of process death(s). Our method does not require kernel or hardware support other than the swap instruction, and maintains performance comparable to the original protocol (one third as fast in the uncontested case). We have proven the correctness of our scheme in the face of the weak memory models provided by modern systems.
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases (2012)

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corneum (air-liquid barrier), tight junctions (liquid-liquid barrier), and the Langerhans cell network (immunological barrier). Clarification of the molecular events underpinning epidermal barrier function and dysfunction should lead to a better understanding of the pathophysiological mechanisms of atopic diseases.