gebhart/patrepeval huggingface dataset:
Design of an improved land/air miniature robot (2010)

Small ground robots remain limited in their locomotion capabilities, often prevented from accessing areas restricted by tall obstacles or rough terrain. This paper presents the improved design of a hybrid-locomotion robot made to address this issue. It uses wheels for ground travel and rotary-wing flight for scaling obstacles and flying over rough terrain. The robot's initial design suffered from a number of issues that prevented it from functioning fully, such as overheating motors, inadequate control electronics, and insufficient landing gear. Several improvements have been made to the robot's design to correct these problems. These obstacles, and the solutions implemented in the improved design, have enabled several design principles to be formulated for miniature hybrid-locomotion robots. It is found that hybrid-locomotion vehicles utilizing rotary-wing flight are most useful when the design is optimized for ground mode performance. Collapsibility is necessary in such vehicles to reduce the impact of the helicopter rotor on the size of the ground mode. Finally, since a large number of actions are necessary to propel and transform the robot, integrating multiple functions into each mechanism can reduce the mass of the robot.
Optimization Of Crossover Frequency And Crossover Region Response For Multichannel Acoustic Applications (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
Involvement of Protease Inhibitors in Staphylokinase-Induced Fibrin-Specific Fibrinolysis. (1994)

We compared the fibrinolytic properties of recombinant staphylokinase (SAK), a fibrin-specific plasminogen activator, with those of streptokinase and tissue-type plasminogen activator (t-PA) by means of the amidolytic method. We also investigated the involvement of alpha 2-macroglobulin, C1-inactivator and alpha 1-antitrypsin in SAK-induced fibrin-specific fibrinolysis. Both SAK and t-PA activated plasminogen efficiently in the presence of fibrin in human plasma. Although t-PA activated plasminogen dependently on fibrin in the reconstituted plasma system, SAK activated plasminogen independently of fibrin without alpha 2-plasmin inhibitor (alpha 2-antiplasmin, alpha 2-PI). These findings suggest that fibrin and alpha 2-PI play important roles in plasminogen activation by SAK but not by t-PA. Furthermore, protease inhibitors such as alpha 2-PI, alpha 2-macroglobulin, C1-inactivator and alpha 1-antitrypsin inhibited plasminogen activation by SAK and the inhibitory actions of these protease inhibitors disappeared in the presence of fibrin. This shows that alpha 2-macroglobulin, C1-inactivator and alpha 1-antitrypsin, other than alpha 2-PI, contribute to the fibrin-specificity of SAK.
Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity (2020)

G-quadruplexes (G4) are non-canonical nucleic acid structures with important implications in biology. Based on an α-helical fragment of the RHAU helicase that displays high specificity for parallel-stranded G-quadrplexes, herein we demonstrate its head-to-tail cyclization by a high-efficiency ligase. The cyclic peptide exhibits superior stability and binding affinity to a G-quadruplex, and can serve as an excellent investigational tool for chemical biology applications.
A New Stilbene Synthase Gene from Muscadine (Vitis rotundifolia) Grape Berry (2007)

Muscadine grapes contain high concentration of polyphenols that are known to be involved in plant defense. Resveratrol encoded by stilbene synthase (STS) is one of the important phenolic compounds found in muscadine grape that has antimicrobial activity as well as health benefit. Cloning and sequencing of STS from muscadine revealed six isoforms of stilbene synthase genes, of which four were found to be different from that of V. vinifera STS sequence (BS). Rapid Amplification of cDNA Ends (RACE) to one of the muscadine stilbene synthase cDNA (MSB1) sequence also showed sequence variation with V. vinifera STS. The expression level ofMSBl and BS gene in anthracnose- tolerant muscadine cultivar was analyzed and confirmed through real time PCR after challenging the grape plants with the fungus Elsinoe ampelina. The expression of MSBl was found to be higher in muscadine compared to V. vinifera confirming that the muscadine genotypes may possibly have the potential to synthesize sufficient amount and type of stilbene phy to alexins to defend against pathogen attack.
Two-dimensional poling of organic and polymer films for improved nonlinear-optical properties (1990)

Nematic films doped with molecules of high nonlinear polarizability can exhibit two-dimensional asymmetry after electric-field poling along one direction only. Consequently, these films exhibit more nonzero components of the second-order susceptibility tensor than are obtained through usual poling techniques. These films can exhibit very high nonlinear optical coefficients (close to 10(-7) esu/cm(3)) and retain most of their nonlinearity one week after removal of the poling field.
Image Processing Techniques in Engineering Geology. Image Processing Technique for Borehole Walls and Its Image Recognition. (1994)

Borehole television, as one of investigation techniques with visual image, is used to investigate borehole walls as a continuous man-made outcrop, and to recognize in-situ rock mass conditions. It has been utilized as an useful method to analysis slope stability and to predict behavior of large rock cavern. Borehole image processing system (BIP System), as of the borehole television method, has been developed owing to the rapid advancement of microprocessors and other electronic devices, which can present images of borehole walls directly as digitized color signals at sites.This paper describes an unique technique of image processing in BIP System, and presents some case histories of detecting discontinuities in rock masses automatically using common method for image recognition.Future view of image processing technique for geological informations are also discussed
Isolation of a cDNA encoding a novel subtilisin-like protease (Pr1B) from the entomopathogenic fungus, Metarhizium anisopliae using differential display-RT-PCR (1997)

Reverse transcription differential display PCR (RT-DD-PCR) was used to identify genes that are specifically expressed by Metarhizium anisopliae when it contacts the host insect cuticle. Using a homology-based subtilisin-like protease primer we identified a hitherto unsuspected differentially expressed subtilisin-like protease (Pr1B) encoding gene. The deduced amino acid sequence shows 54% similarity to the well characterized Pr1A subtilisin of M. anisopliae and karyotype analysis revealed that Pr1A and Pr1B are located on separate chromosomes. Like Pr1A, Pr1B is synthesized as a large precursor (1158 nucleotides; deduced molecular mass = 40031 Da) containing a signal peptide, a propeptide and the mature protease (283 aa; deduced molecular mass = 28714 Da). However, Pr1B possesses several substitutions in the highly conserved sequences comprising the active sites of subtilisins. In particular, the substitution of Thr220 by serine is unique to Pr1B. Substitution of Asn155 by glycine is also very unusual, and we discuss the likely effects these changes will have on the catalytic efficiency of Pr1B.
Identification of tumor vascular antigens by monoclonal antibodies prepared from rat-tumor-derived endothelial cells (1998)

We have reported the isolation and specific in vitro properties of tumor-derived endothelial cells (TEC) from rat KMT-17 fibrosarcomas transplanted into rats. To develop antibody-based tumor vascular targeting therapy for solid tumors, we have generated monoclonal antibodies (MAbs) using passive immunization of outside-out membrane vesicles of rat epididymal-fat-pad-derived capillary endothelial cells (FCEC) followed by active immunization of those of rat TEC. The MAbs produced were screened against TEC and FCEC. Of all cultured hybridomas, 75 (3.3%) of the secreted MAbs preferentially recognized TEC. We selected a total of 7 MAbs which detected antigens highly abundant in TEC, although 5 of the 7 MAbs were weakly positive for FCEC in cell-ELISA and FACS analyses. The antigens recognized by these MAbs, with the exception of MAb TES-7, were present on endothelial cells of tumor blood vessels in KMT-17 fibrosarcoma tissues, as shown by immunohistochemical analysis. Antigens of 40- and 80-kDa were recognized by MAbs TES-1, 7, 17, 21 and 26 and by MAbs TES-23 and 27 respectively. Although the function of these antigens, which are preferentially expressed on rat tumor-derived endothelial cells, is still unknown, we believe that future studies of such antigens will help elucidate the role of endothelial cells in tumor vasculature. Our results indicate that MAbs may provide a novel tool for the development of antibody-based therapy targeting tumor vasculature.
Multiple effects of the starch synthase II mutation in developing wheat endosperm (2007)

A line of wheat (Triticum aestivum L.), sgp-1, that does not express starch synthase II (SSII, also known as SGP-1) has previously been reported. In this study, F1 derived doubled haploid lines with homozygous wild type or mutant alleles for SGP-1 genes were identified from a cross between the original mutant and a wild type Australian cultivar. Analysis of the starch granules showed that in the mutant lines they are markedly distorted from 15 days postanthesis during grain development. Starch branching patterns showed an increase in the proportion of short chains (DP 6-10) at an earlier stage, but this increase became much more pronounced at 15 days postanthesis and persisted until maturity. There was also a consistent and drastic reduction throughout seed development in the relative amounts of starch branching enzyme II (SBEII, comprising SBEIIa and SBEIIb) and starch synthase I (SSI) bound to the starch granules. In the soluble phase, however, there was relatively little change in the amount of SBEIIb, SBEIIa or SSI protein. Therefore loss of SSII specifically leads to the loss of SBEIIb, SBEIIa and SSI protein in the granule-bound phase and the effect of this mutation is clearly manifest from the mid-stage of endosperm development in wheat.
Targeted Protein Surface Sensors as a Tool for Analyzing Small Populations of Proteins in Biological Mixtures (2014)

Abstract Optical cross‐reactive sensor arrays (the so‐called chemical “noses/tongues”) have recently been demonstrated as a powerful tool for high‐throughput protein detecting and analysis. Nevertheless, applying this technology to biomarker detection is complicated by the difficulty of non‐selective sensors to operate in biological mixtures. Herein we demonstrate a step toward circumventing this limitation by using self‐assembled fluorescent receptors consisting of two distinct recognition motifs: specific and non‐specific. When combined in an array, binding cooperatively between the specific and non‐specific protein binders enables the system to discriminate among closely related isoform biomarkers even in the presence of serum proteins or within human urine.
Binomial Checkpointing for Arbitrary Programs with No User Annotation (2016)

Heretofore, automatic checkpointing at procedure-call boundaries, to reduce the space complexity of reverse mode, has been provided by systems like Tapenade. However, binomial checkpointing, or treeverse, has only been provided in Automatic Differentiation (AD) systems in special cases, e.g., through user-provided pragmas on DO loops in Tapenade, or as the nested taping mechanism in adol-c for time integration processes, which requires that user code be refactored. We present a framework for applying binomial checkpointing to arbitrary code with no special annotation or refactoring required. This is accomplished by applying binomial checkpointing directly to a program trace. This trace is produced by a general-purpose checkpointing mechanism that is orthogonal to AD.
Matrix Permittivity Measurements for Rock Powders (2016)

Summary Formation water content is one of the key petrophysical quantities provided by dielectric logging. However, to determine water content from formation permittivity measurements, the rock matrix permittivity must be known. Uncertainty in the rock matrix permittivity values translates into uncertainty in the water-content estimate, which is especially important in low-porosity formations or complex lithologies. Matrix permittivity values are not well-known for a number of minerals and can also vary for the same type of mineral in different formations. Thus, a laboratory methodology for the accurate determination of matrix permittivity at dielectric logging frequencies is required to facilitate accurate log interpretation. One can measure matrix permittivity values on solid plugs (Seleznev et al. 2011). However, the plug-based methodology can be challenging in very-low-permeability or unconventional reservoirs because of difficulties with plug drying. In addition, it is not readily applicable to unconsolidated formations. Finally, it may be impossible to cut solid plugs because of limited availability of rock material. Matrix permittivity measurements made on rock powders are capable of addressing all these issues. We introduce a methodology for laboratory measurements of matrix permittivity on rock powders at 1 GHz. The methodology is based on conducting dielectric measurements on mixtures of rock powders and liquids with variable permittivities in a dielectric resonator. The permittivity of the rock matrix is inverted from a series of measurements obtained on pure liquids and powder/liquid mixtures. The methodology was benchmarked on a collection of samples representing common oilfield lithologies with matrix-permittivity values between 4.6 and 8.6. The reference matrix-permittivity values were first measured on solid plugs. Then, the plugs were crushed into powders, and the matrix permittivity values were determined on powders following the proposed methodology. The values obtained on powders matched the ones measured on solid plugs within 0.2 dielectric units, resulting in accuracies better than 1% for the water-filled porosity and better than 1,000 ppm for water salinity. This new methodology was applied to a number of core samples from a carbonate reservoir offshore Sarawak, where dielectric logging was performed along with conventional core analysis. The resulting measured matrix permittivity values were then used to interpret the dielectric log measurement. Results showed a better estimation of water-filled porosity and of the textural MN parameter, equivalent to the Archie's cementation exponent in a water-bearing zone, than would have resulted from using “chartbook” values of matrix permittivity. A consistent and optimized interpretation was obtained in porosities ranging from 5% to more than 30%.
P‐192: Advanced Transflective Multi‐Domain Vertical Aligned Liquid Crystal Display (ATR‐MVA LCD) with Micro Bump Technology (2008)

Abstract We have developed a high performance but low cost advanced transflective multi‐domain vertical aligned liquid crystal display (ATR‐MVA LCD) by using micro bump technology. ATR‐MVA LCD does not need additional process of reflective mode by micro‐bump design. for example, 4.0 inches ATR‐MVA LCD's reflectance achieves 1.25% with 7% reflective aperture ratios.
Major role of collagen IIB in the elevation of total type II procollagen messenger RNA in the hypertrophic phase of experimental osteoarthritis (1997)

Although OA chondrocytes adapt to making immature forms of aggrecan proteoglycan, they do not revert to the prechondrocyte stage characterized by IIA mRNA expression.
The Effect of a Nutritional Supplement on Growth and Body Composition in Short and Lean Preadolescent Boys following One Year of Intervention (2022)

An intervention in healthy peripubertal boys suggests that 1-year consumption of a multi-nutrient, protein-rich nutritional supplement is efficacious and safe. The induced changes in growth and body composition, although modest, may be clinically significant. The effect of the formula on growth parameters was not mediated by enhancement of the pubertal tempo.
Piezoelectric Micromachined Ultrasonic Transducers for Range-Finding Applications (2021)

This paper presents the basic design equations and equivalent circuit model for piezoelectric micromachined ultrasonic transducers (PMUTs) used in time-of-flight range-finding applications. A model for acoustic propagation loss is shown and compared to experimental results for a commercially-available PMUT-based time-of-flight sensor operating to a maximum pulse-echo range of 5 m.
A novel slope detection technique for robust STTRAM sensing (2015)

Spin-Torque-Transfer RAM (STTRAM) is a promising technology for high density on-chip cache due to low standby power and high speed. However, the process variation of magnetic tunnel junction (MTJ) and access transistor poses serious challenge to sensing. Nondestructive sensing suffers from reference resistance variation whereas destructive sensing suffers from failures due to unoptimized selection of data and reference currents. We propose a novel slope detection technique to exploit MTJ resistance switching from high to low state using low-overhead sample-and-hold circuit. The proposed sensing technique is destructive in nature and can be combined with double sampling for improved robustness. Simulation results reveal <;0.12% failure under process variation using single sampling (at 0.2% area overhead) and <;0.08% failures with double sampling (at 0.6% area overhead). The overall sense time is found to be 6.8ns.
[Succinic acid production with Escherichia coli AFP111 recovered from fermentation]. (2013)

During the anaerobic fermentation by Escherichia coli AFP111 for succinic acid production, the viable cell concentration and productivity were decreased with the raising of succinic acid concentration. In order to restore cellular succinic acid productivity and prolong fermentation time, we collected strains and refreshed medium for repetitive succinic acid production. However, productivity is lower than that in the anaerobic fermentation before reusing strains. To enhance the productivity, strains were aerobically cultivated for 3 h in pure water before anaerobic fermentation. The activities of key enzymes were enhanced for better performance in producing succinic acid at anaerobic stage. After three rounds of repetitive fermentations, succinic acid concentration and yield reached to 56.50 g/L and 90% respectively. The succinic acid productivity was 0.81 g/(L x h), which was 13% higher than the repetitive fermentations without aerobic activation of the strains.
<title>Novel x-ray tube with a line filament</title> (2001)

A novel x-ray tube has been produced by using a line filament as a cathode. It is found that the electrons emitted form the filament arrive on the anode in a line perpendicular to the direction of the filament. The image of the x-ray emitting area on the anode obtained with a x-ray pinhole camera and a CCD detector shows a slightly curved line. The formation of this curved line is explained by Monte Carlo calculations, which include electric and magnetic fields in the x-ray tube as well as Joule heating, surface cooling, and thermal conduction in the cathode. The experimental result sand the result form the Monte Carlo calculations are presented.
A Generalized Formulation for Adaptive Pulse Compression of Multistatic Radar (2006)

For the return signal at a radar receiver comprised of radar returns from K illuminating radars operating in the same spectrum in near proximity, the multistatic adaptive pulse compression (MAPC) algorithm has been shown to effectively separate and subsequently pulse compress the multiple signals such that range sidelobes and cross-correlation sidelobes are minimized in the mean square-error (MSE) sense. This previous formulation implicitly assumed that the K radars possess very good control of sidelobe emissions. However, sidelobe control on transmit results in mainbeam spreading and loss, which is often unacceptable. In this paper, a generalized framework is developed which accounts for all of the inherent signals that are incident at a given radar receiver. In general, these signals collectively originate from the respective transmit mainbeams and sidelobes of the K illuminating radars and are then reflected into the receive mainbeam and sidelobes of the given radar receiver
Alzheimer’s Retinopathy: Seeing Disease in the Eyes (2020)

The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD) pathology. As a CNS extension of the brain, the neuro retina is easily accessible for noninvasive, high-resolution imaging. Studies have shown that along with cognitive decline, patients with mild cognitive impairment (MCI) and AD often suffer from visual impairments, abnormal electroretinogram patterns, and circadian rhythm disturbances that can, at least in part, be attributed to retinal damage. Over a decade ago, our group identified the main pathological hallmark of AD, amyloid β-protein (Aβ) plaques, in the retina of patients including early-stage clinical cases. Subsequent histological, biochemical and <i>in vivo</i> retinal imaging studies in animal models and in humans corroborated these findings and further revealed other signs of AD neuropathology in the retina. Among these signs, hyperphosphorylated tau, neuronal degeneration, retinal thinning, vascular abnormalities and gliosis were documented. Further, linear correlations between the severity of retinal and brain Aβ concentrations and plaque pathology were described. More recently, extensive retinal pericyte loss along with vascular platelet-derived growth factor receptor-β deficiency were discovered in postmortem retinas of MCI and AD patients. This progressive loss was closely associated with increased retinal vascular amyloidosis and predicted cerebral amyloid angiopathy scores. These studies brought excitement to the field of retinal exploration in AD. Indeed, many questions still remain open, such as queries related to the temporal progression of AD-related pathology in the retina compared to the brain, the relations between retinal and cerebral changes and whether retinal signs can predict cognitive decline. The extent to which AD affects the retina, including the susceptibility of certain topographical regions and cell types, is currently under intense investigation. Advances in retinal amyloid imaging, hyperspectral imaging, optical coherence tomography, and OCT-angiography encourage the use of such modalities to achieve more accurate, patient- and user-friendly, noninvasive detection and monitoring of AD. In this review, we summarize the current status in the field while addressing the many unknowns regarding Alzheimer's retinopathy.
The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis (1999)

Arthritis can be generated by systemic recognition of self-MHC-peptide complexes by autoreactive T cells. This triggers B lymphocytes to produce arthritogenic antibodies, without the involvement of joint-specific T cell targets.
T cells expressing CD123 chimeric antigen receptors for treatment of acute myeloid leukemia (2015)

CD123 is an attractive surface target for novel antileukemic therapies. CD123 CAR T-cell-based immunotherapy is a promising treatment for patients with relapsed or refractory acute myeloid leukemia.