gebhart/patrepeval huggingface dataset:
Substitution-induced phase transition and enhanced multiferroic properties of Bi1−xLaxFeO3 ceramics (2006)

Single-phase, insulating Bi1−xLaxFeO3 (BLFOx, x=0.05, 0.10, 0.15, 0.20, 0.30, and 0.40) ceramics were prepared. An obvious phase transition from rhombohedral to orthorhombic phase was observed near x=0.30. It is found that the phase transition destructs the spin cycloid of BiFeO3 (BFO), and therefore, releases the locked magnetization and enhances magnetoelectric interaction. As a result, improved multiferroic properties of the BLFO0.30 ceramics with remnant polarization and magnetization (2Pr and 2Mr) of 22.4μC∕cm2 and 0.041emu∕g, respectively, were established.
Degradation of AlGaN during high-temperature annealing monitored by ultraviolet Raman scattering (1999)

We have illustrated the use of ultraviolet (UV) Raman scattering to investigate the thermal stability of AlGaN layers with high-aluminum content. The degradation pathway of Al0.72Ga0.28N was monitored for high-temperature treatments up to 1200 °C. For annealing temperatures higher than 1150 °C, the Al0.72Ga0.28N film decomposes: a low- and a high-aluminum composition AlxGa1−xN phase emerge. At 1100 °C, prior to the Al0.72Ga0.28N decomposition, UV Raman scattering detects the buildup of a large strain in the Al0.72Ga0.28N film. The crystalline quality of Al0.72Ga0.28N is unaffected up to 1000 °C.
[Angiogenesis in vitro]. (1999)

A quantitative angiogenesis in vitro was investigated by culturing bovine carotid artery endothelial cells between two layers of type I collagen gel. Cells become organized into tube-like structures within few days. Ultrastructurally, tubular structures were composed of one to several endothelial cells containing pinocytotic vesicles and cytoplasmic projections, and linked by junctional complexes. A basal lamina-like structure surrounded the abluminal surface. Glucose, insulin, insulin-like growth factor I at pathophysiological high concentrations significantly stimulated tube-forming activity of endothelial cells by stimulating cell migration.
Adenosine enhances analgesic effect of tricyclic antidepressants (1994)

lntraperitoneal administration of adenosine (10 mg/kg) enhanced the analgesic effect of tricyclic antidepressant (TCA) imipramine or amitriptyline in the tail flick test. Theophylline (50 mg/kg) or caffeine (50 mg/kg), purinoceptor antagonists, attenuated the analgesic response not only of TCA alone but also of adenosine and TCA combination. These results indicate that TCA induced analgesia may be mediated through adenosinergic system and thus provide new evidence for their interaction.
Closed-Loop Control of Direct Ink Writing via Reinforcement Learning (2022)

Enabling additive manufacturing to employ a wide range of novel, functional materials can be a major boost to this technology. However, making such materials printable requires painstaking trial-and-error by an expert operator, as they typically tend to exhibit peculiar rheological or hysteresis properties. Even in the case of successfully finding the process parameters, there is no guarantee of print-to-print consistency due to material differences between batches. These challenges make closed-loop feedback an attractive option where the process parameters are adjusted on-the-fly. There are several challenges for designing an efficient controller: the deposition parameters are complex and highly coupled, artifacts occur after long time horizons, simulating the deposition is computationally costly, and learning on hardware is intractable. In this work, we demonstrate the feasibility of learning a closed-loop control policy for additive manufacturing using reinforcement learning. We show that approximate, but efficient, numerical simulation is sufficient as long as it allows learning the behavioral patterns of deposition that translate to real-world experiences. In combination with reinforcement learning, our model can be used to discover control policies that outperform baseline controllers. Furthermore, the recovered policies have a minimal sim-to-real gap. We showcase this by applying our control policy in-vivo on a single-layer, direct ink writing printer.
Activation Tagging Using the <i>En-I</i> Maize Transposon System in Arabidopsis (2002)

A method for the generation of stable activation tag inserts was developed in Arabidopsis using the maize (Zea mays) En-I transposon system. The method employs greenhouse selectable marker genes that are useful to efficiently generate large populations of insertions. A population of about 8,300 independent stable activation tag inserts has been produced. Greenhouse-based screens for mutants in a group of plants containing about 2,900 insertions revealed about 31 dominant mutants, suggesting a dominant mutant frequency of about 1%. From the first batch of about 400 stable insertions screened in the greenhouse, four gain-in-function, dominant activation-tagged, morphological mutants were identified. A novel gain-in-function mutant called thread is described, in which the target gene belongs to the same family as the YUCCA flavin-mono-oxygenase that was identified by T-DNA activation tagging. The high frequency of identified gain-in-function mutants in the population suggests that the En-I system described here is an efficient strategy to saturate plant genomes with activation tag inserts. Because only a small number of primary transformants are required to generate an activation tag population, the En-I system appears to be an attractive alternative to study plant species where the present transformation methods have low efficiencies.
Spring-Clutch: A safe torque limiter based on a spring and CAM mechanism with the ability to reinitialize its position (2009)

Service robots are anticipated to be used in unstructured areas such as homes, hospitals, and public areas in the near future. However, safety issues need to be addressed before this can occur. In particular, robot manipulators that handle objects by physical contact run the risk of colliding with people or objects. Thus, it is important to prevent collisions that could injure people and damage robot manipulators. In this study, a safe joint mechanism is developed to ensure the safe use of a manipulator. This mechanism, termed `Spring-Clutch,' is a simple passive mechanism that consists of a coil spring and a CAM mechanism. When a torque is applied that is less than a threshold value, Spring-Clutch functions as a rigid joint between the input and the output. However, when an applied torque exceeds the threshold, angular displacement occurs between the input and output to reduce the collision force. If the applied torque is removed, Spring-Clutch immediately returns to its nominal position without the need for additional operations. This paper describes the design principles and performance of Spring-Clutch, and discusses the possibility of its practical use as a joint mechanism for safe manipulation.
Impact of controlled sprouting of wheat kernels on bread baking performance (2017)

A laboratory-scale method for wheat germination was developed and used to compare hard red winter wheat varieties for sprout related attributes, activity, and whole wheat bread baking performance.WB 4458, WB Grainfield, LCS Mint, LCS Wizard, SY Monument, and T158 wheat varieties grown in three Kansas locations were germinated with the developed small-scale germination method and falling number values were compared.Byrd, Tam 204, and T158 were germinated with a scaled-up germination method aimed at generating samples in three falling number ranges of less than 120 seconds (low falling number and highly sprouted), 25040 seconds (medium falling number), and 35040 seconds (high falling number and low sprouting).Controls were un-germinated, sound (>400 seconds falling number), samples of each variety.The control whole grain and sprouted wheat was ground into flour.A mixograph was used to determine dough water absorption and mixing time.Whole wheat bread was made to determine bread volume, crumb characteristics, and bread texture.Overall there were few significant differences within each wheat variety for the different levels of germination.The only significant difference observed in all three varieties was that each highly sprouted grain (<120 seconds falling number) produced bread with significantly lower elasticity than the control within each variety, indicating that this level of germination produced a gummier bread.Elasticity was positively correlated with falling number (r=+0.71).A focused analysis on the Byrd variety compared the germinated samples to samples generated with added malted barley to the same falling number ranges.RVA analysis showed the gelatinization profiles for germinated and malted samples were similar within each falling number range.The highly and medium sprouted grain had significantly lower dough water absorption than the malted counterparts for those levels and the medium sprouted grain also had a lower mix time then the malted sample.
Tetrathiomolybdate as an antiangiogenesis therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration. (2002)

At the dosages used in this study, tetrathiomolybdate was ineffective in preventing the progression of CNV secondary to age-related macular degeneration.
Adverse Effects of COX-2 Inhibitors (2005)

Cyclooxygenase-2 selective inhibitors (COXIBs) were developed with the prime object of minimizing gastrointestinal adverse effects, which are seen with the use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs). Their long-term use is limited by the development of hypertension, edema, and congestive heart failure in a significant proportion of patients. NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H2 (PGH2) and other prostaglandin (PG) metabolites. It is well established that the cardiovascular profile of COX-2 inhibitors can be accounted for by inhibition of COX-dependent PG synthesis. Following the COX-mediated synthesis of PGH2 from arachidonate, PGH2 is metabolized to one of at least five bioactive PGs, including PGE2, PGI2, PGF2, PGD2, or thromboxane A2 (TXA2). These prostanoids have pleiotropic cardiovascular effects, altering platelet function and renal function, and they are acting either as vasodilators or vasoconstrictors. Although COX-1 and COX-2 exhibit similar biochemical activity in converting arachidonate to PGH2 in vitro, the ultimate prostanoids they produce in vivo may be different due to differential regulation of COX-1 and COX-2, tissue distribution, and availability of the prostanoid synthases. PGs have been established as being critically involved in mitigating hypertension, helping to maintain medullary blood flow (MBF), promoting urinary salt excretion, and preserving the normal homeostasis of thrombosis, and the researchers found that the use of COX-2 inhibitors caused many serious complications in altering the normal body homeostasis. The purpose of the present research is to explain briefly the side effects of COX-2 inhibitors on the renal and cardiovascular system.
Critical review on where CRISPR meets molecular diagnostics (2020)

Abstract Simple yet powerful clustered regularly-interspaced short palindromic repeats (CRISPR) technology has led to the advent of numerous developments in life sciences, biotechnology, therapeutics, and molecular diagnostics, enabled by gene editing capability. By exploiting the CRISPR-Cas system’s nucleic acid sequence detection abilities, CRISPR-based molecular diagnostics have been developed. Here, we review the development of rapid, sensitive, and inexpensive CRISPR-based molecular diagnostics. We introduce the transition of CRISPR technology to precision molecular diagnostic devices from tube to device. Next, we discuss the various nucleic acid (NA) detection methods by CRISPR. We address the importance of significant sample preparation steps for a future sample-to-answer solution, which is lacking in current CRISPR-based molecular diagnostic technology. Lastly, we discuss the extension of CRISPR-based molecular diagnostics to various critical applications. We envision CRISPR technology holds great promise for widespread use in precision NA detection applications after particular technical challenges are overcome.
Seeding Techniques and Scaffolding Choice for Tissue Engineering of the Temporomandibular Joint Disk (2004)

Temporomandibular joint (TMJ) disk removal, or diskectomy, is a detrimental yet necessary surgery for patients with extremely displaced disks. Tissue engineering is an enticing methodology for improvement of the postoperative outcome of diskectomy. Unfortunately, the field of tissue engineering of the TMJ disk is only in the early stages of development. The initial objective of this investigation was to study the cellular response of TMJ disk cells in alginate culture. However, a marked decrease in cell population and the lack of detection of extracellular matrix (ECM) products did not support the use of alginate culture. The second objective was then to attempt TMJ disk cell culture in polyglycolic acid (PGA) nonwoven meshes. However, as suitable seeding methods for TMJ disk cells on PGA had not been determined, three techniques were selected for study: spinner flask, orbital shaker, and a novel pelleting technique. PGA constructs maintained cellularity throughout the culture period, and scaffolds seeded with the spinner flask produced about 35 microg of collagen per construct. Thus, as evidenced by the production of a major extracellular component, PGA nonwoven meshes seeded with TMJ disk cells, using a spinner flask, may be a first positive culturing step in tissue engineering the TMJ disk.
Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis (2014)

Arterial pulse pressure has been widely used as surrogate of stroke volume, for example, in the guidance of fluid therapy. However, recent experimental investigations suggest that arterial pulse pressure is not linearly proportional to stroke volume. However, mechanisms underlying the relation between the two have not been clearly understood. The goal of this study was to elucidate how arterial pulse pressure and stroke volume respond to a perturbation in the left ventricular blood volume based on a systematic mathematical analysis. Both our mathematical analysis and experimental data showed that the relative change in arterial pulse pressure due to a left ventricular blood volume perturbation was consistently smaller than the corresponding relative change in stroke volume, due to the nonlinear left ventricular pressure-volume relation during diastole that reduces the sensitivity of arterial pulse pressure to perturbations in the left ventricular blood volume. Therefore, arterial pulse pressure must be used with care when used as surrogate of stroke volume in guiding fluid therapy.
Acquired sideroblastic anaemia during treatment of Wilson's disease with triethylene tetramine dihydrochloride (1993)

We report one case of acquired sideroblastic anaemia in a patient treated for Wilson's disease with triethylene tetramine dihydrochloride (TTH). No other cause of acquired sideroblastic anaemia was found, and neither iron nor pyridoxine therapy could correct this anaemia. In contrast, decreasing the dose of TTH led to disappearance of ringed sideroblasts. Thus TTH should be added as a further cause of secondary acquired sideroblastic anaemia. The pathophysiology of this finding, probably linked to an abnormality of mitochondrial iron metabolism, is briefly discussed.
Attacin, an antibacterial protein from Hyalophora cecropia, inhibits synthesis of outer membrane proteins in Escherichia coli by interfering with omp gene transcription (1991)

Attacins are antibacterial proteins synthesized by pupae of the giant silk moth, Hyalophora cecropia, in response to a bacterial infection. In this report we show that the previously described, attacin-induced alteration in the structure and the permeability of the outer membrane of Escherichia coli is associated with a specific inhibition of the synthesis of several outer membrane proteins, including OmpC, OmpF, OmpA, and LamB. The inhibition is expressed as a reduction in the steady-state mRNA levels and is at least in part the results of a block in transcription of the corresponding genes. Transcription directed by the promoter of ompR, the positive regulator of ompC and ompF expression in response to environmental conditions, is also affected by attacin. The effects on mutant strains show that the primary activity of attacin is not mediated by the ompR-envZ regulatory system. Instead our data suggest the existence in E. coli of a previously unknown system for the transcriptional regulation of a large set of outer membrane proteins previously not known to be coordinately regulated. We propose that the activity of attacin is directed towards this system.
Glycosylation-dependent inactivation of the ecotropic murine leukemia virus receptor (1994)

The ecotropic murine leukemia virus (E-MuLV) receptor expressed on Mus dunni tail fibroblast (MDTF) cells is a receptor for all E-MuLVs with the notable of Moloney murine leukemia virus (Mo-MuLV). Substitution of isoleucine for valine at position 214 in the third extracellular region (the putative E-MuLV binding site) of the MDTF receptor molecule allows this molecule to function as a Mo-MuLV receptor (M.V. Eiden, K. Farrell, J. Warsowe, L. A. Mahan, and C. A. Wilson, J. Virol. 67:4056-4061, 1993). We have now determined that treating MDTF cells with tunicamycin, an inhibitor of N-linked glycosylation, also renders them susceptible to Mo-MuLV infection. Two potential N-linked glycosylation sites are present in the third extracellular regions of both the NIH 3T3 and MDTF ecotropic receptors. The glycosylation site at position 229 of the MDTF receptor cDNA was eliminated by substituting a threonine codon for the asparagine codon. Mo-MuLV-resistant human HOS cells, expressing this form of the receptor, are susceptible to Mo-MuLV infection. Thus, our studies suggest that without a glycan moiety at position 229, the valine residue at 214 is no longer restrictive for Mo-MuLV infection. BHK-21 and CHO K1 hamster cells also express glycosylation-inactivated forms of the ecotropic receptor. Sequence analysis of these receptors together with our analysis of MDTF receptor function suggests that a single asparagine-linked glycosylation site is responsible for glycosylation inactivation of these receptors.
Data mining approaches for life cycle assessment (2011)

To reduce the cost associated with screening lifecycle assessments (LCAs), we propose treating LCA as a data mining problem and automating the process of assigning impact factors to inventory components. We describe three sub-problems involved in automating LCA and provide illustrative case studies for each. The results from an automated data mining approach are comparable to those obtained from the more laborious manual LCA process.
Depth Estimation via Affinity Learned with Convolutional Spatial Propagation Network (2018)

Depth estimation from a single image is a fundamental problem in computer vision. In this paper, we propose a simple yet effective convolutional spatial propagation network (CSPN) to learn the affinity matrix for depth prediction. Specifically, we adopt an efficient linear propagation model, where the propagation is performed with a manner of recurrent convolutional operation, and the affinity among neighboring pixels is learned through a deep convolutional neural network (CNN). We apply the designed CSPN to two depth estimation tasks given a single image: (1) To refine the depth output from state-of-the-art (SOTA) existing methods; and (2) to convert sparse depth samples to a dense depth map by embedding the depth samples within the propagation procedure. The second task is inspired by the availability of LIDARs that provides sparse but accurate depth measurements. We experimented the proposed CSPN over two popular benchmarks for depth estimation, i.e. NYU v2 and KITTI, where we show that our proposed approach improves in not only quality (e.g., 30% more reduction in depth error), but also speed (e.g., 2 to 5 times faster) than prior SOTA methods.
The Rolling Contact of Two Elastic-Layer-Covered Cylinders Driving a Loaded Sheet in the Nip (1981)

A circular stress function is used for the steady rolling contact of two cylinders. Each cylinder has an elastic layer bonded to a hard core, and an elastic thin sheet is compressed in the contact arc and being driven by the system. An asymmetric stress distribution is caused by a pushing or pulling force acting at the tail end of the sheet. The effect of the normal load and the tail force on the speed ratios of the two cylinders and the sheet, and also the local slippage in the contact arc are studied by enforcing the exact conditions at the contact zone. The resulting equations are solved by the collocation method and an iterative procedure which stepwisely unlocked the nonslip contacting points whenever the calculated interface shear exceeds the local Coulomb friction.
Nodulation of Crotalaria podocarpa DC. by Methylobacterium nodulans displays very unusual features (2011)

Crotalaria are plants of the Fabaceae family whose nodulation characteristics have been little explored despite the recent discovery of their unexpected ability to be efficiently nodulated in symbiosis with bacteria of the genus Methylobacterium. It has been shown that methylotrophy plays a key role in this unusual symbiotic system, as it is expressed within the nodule and as non-methylotroph mutants had a depleting effect on plant growth response. Within the nodule, Methylobacterium is thus able to obtain carbon both from host plant photosynthesis and from methylotrophy. In this context, the aim of the present study was to show the histological and cytological impacts of both symbiotic and methylotrophic metabolism within Crotalaria podocarpa nodules. It was established that if Crotalaria nodules are multilobed, each lobe has the morphology of indeterminate nodules but with a different anatomy; that is, without root hair infection or infection threads. In the fixation zone, bacteroids display a spherical shape and there is no uninfected cell. Crotalaria nodulation by Methylobacterium displayed some very unusual characteristics such as starch storage within bacteroid-filled cells of the fixation zone and also the complete lysis of apical nodular tissues (where bacteria have a free-living shape and express methylotrophy). This lysis could possibly reflect the bacterial degradation of plant wall pectins through bacterial pectin methyl esterases, thus producing methanol as a substrate, allowing bacterial multiplication before release from the nodule.
A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women (2014)

N. sativa is thought to have multiple mechanisms of action and is cost-effective. Therefore, it could be used by menopausal women to remedy hypercholesterolemia, with likely more benefits than with single pharmacological agents that may cause side effects. The use of N. sativa as an alternative therapy for hypercholesterolemia could have profound impact on the management of CVD among menopausal women especially in countries where it is readily available.
Immunocytochemical localization of simian virus 40 T antigen with peroxidase-labeled antibody fragments (1976)

T antigen was localized in simian virus 40 lytically infected and transformed cells by Fab' antibody conjugates at the ultrastructural level. This virus-specific protein appeared in the cytoplasm of permissive cells as early as 3 h after infection. At later time intervals, the T antigen was localized in both the cytoplasm and nucleus and finally (24 h) in the nucleus. These results suggest a synthesis of T antigen on cytoplasmic ribosomes, with subsequent transfer to the nucleus.