gebhart/patrepeval huggingface dataset:
A Simple Conversion of Artemisinic Acid into Artemisinin (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Simple Conversion of Artemisinic Acid into ArtemisininRonald J. Roth and Nancy ActonCite this: J. Nat. Prod. 1989, 52, 5, 1183–1185Publication Date (Print):September 1, 1989Publication History Published online1 July 2004Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/np50065a050https://doi.org/10.1021/np50065a050research-articleACS PublicationsRequest reuse permissionsArticle Views1372Altmetric-Citations129LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Methodology for SIP and SOAP Integration Using Application-Specific Protocol Conversion (2012)

In recent years, the ubiquitous demands for cross-protocol application access are driving the need for deeper integration between SIP and SOAP. In this article we present a novel methodology for integrating these two protocols. Through an analysis of properties of SIP and SOAP we show that integration between these protocols should be based on application-specific converters. We describe a generic SIP/SOAP gateway that implements message handling and network and storage management while relying on application-specific converters to define session management and message mapping for a specific set of SIP and SOAP communication nodes. In order to ease development of these converters, we introduce an XML-based domain-specific language for describing application-specific conversion processes. We show how conversion processes can be easily specified in the language using message sequence diagrams of the desired interaction. We evaluate the presented methodology through performance analysis of the developed prototype gateway and high-level comparison with other solutions.
Auto-aligning stimulated emission depletion microscope using adaptive optics (2013)

Stimulated emission depletion (STED) microscopy provides diffraction-unlimited resolution in fluorescence microscopy. Imaging at the nanoscale, however, requires precise alignment of the depletion and excitation laser foci of the STED microscope. We demonstrate here that adaptive optics can be implemented to automatically align STED and confocal images with a precision of 4.3 ± 2.3 nm.
Interference techniques in digital holography (2006)

Interference techniques in digital holography are discussed and experimental results from each technique are presented. Numerical reconstruction algorithms for digital holography are reviewed. The angular spectrum method is seen to be particularly advantageous, with the ability to remove noise and unwanted holographic terms. The dual wavelength optical unwrapping technique offers an unambiguous method of removing 2π phase discontinuity. Application of wavelength-scanning digital interference holography is used to obtain tomographic images with synthesized short coherence length.
N-Glycan Modification in <i>Aspergillus</i> Species (2007)

The production by filamentous fungi of therapeutic glycoproteins intended for use in mammals is held back by the inherent difference in protein N-glycosylation and by the inability of the fungal cell to modify proteins with mammalian glycosylation structures. Here, we report protein N-glycan engineering in two Aspergillus species. We functionally expressed in the fungal hosts heterologous chimeric fusion proteins containing different localization peptides and catalytic domains. This strategy allowed the isolation of a strain with a functional alpha-1,2-mannosidase producing increased amounts of N-glycans of the Man5GlcNAc2 type. This strain was further engineered by the introduction of a functional GlcNAc transferase I construct yielding GlcNAcMan5GlcNac2 N-glycans. Additionally, we deleted algC genes coding for an enzyme involved in an early step of the fungal glycosylation pathway yielding Man3GlcNAc2 N-glycans. This modification of fungal glycosylation is a step toward the ability to produce humanized complex N-glycans on therapeutic proteins in filamentous fungi.
Improvement of predictive models of risk of disease progression in chronic hepatitis C by incorporating longitudinal data (2015)

Prediction models that incorporate longitudinal data can capture nonlinear disease progression in chronic hepatitis C and thus outperform baseline models. Machine learning methods can capture complex relationships between predictors and outcomes, yielding more accurate predictions; our models can help target costly therapies to patients with the most urgent need, guide the intensity of clinical monitoring required, and provide prognostic information to patients.
Dynamic-sleep transistor and body bias for active leakage power control of microprocessors (2003)

Sleep transistors and body bias are used to control active leakage for a 32b integer execution core implemented in a 100nm dual V, CMOS technology. A PMOS sleep transistor degrades performance by 4% but offers 20/spl times/ leakage reduction which is further improved with body bias. Time constants for leakage convergence range from 30ns to 300ns allowing 9-44% power savings for idle periods greater than 100 clock cycles.
Role of Enterococci in Cheddar Cheese: Proteolytic Activity and Lactic Acid Development1 (1975)

Eight lots of Cheddar cheese were manufactured by using two strains of Streptococcus faecalis and Streptococcus durans in combination with a commercial lactic culture. Each lot consisted of a control vat of cheese, manufactured with lactic starter only, and an experimental vat of cheese containing the lactic starter and one of the enterococcus strains. Combinations of two curing temperatures (7.2 and 12.8 C) and two early cooling treatments (air vs. brine cooling) were used for cheeses from each vat to determine the effects of these handling procedures, as well as of enterococcus addition, on proteolysis and lactic acid development. These characteristics were monitored from milling to up to 6 months of curing. Cheeses manufactured with S. faecalis exhibited more protein breakdown than did the control cheeses and those made with S. durans, the latter two being nearly identical in the extent of proteolysis. More proteolysis was consistently observed in those cheeses cured at 12.8 C. No statistical difference was observed inproteolytic activity between air- and brine-cooled cheeses. Cheeses made with S. durans had a higher final percentage of lactic acid than did controls and cheeses made with S. faecalis. Cheeses manufactured with enterococci exhibited a more rapid initial production of lactate. Cheeses cured at 12.8 C had greater percentages of lactic acid compared with those cured at 7.2 C. Air-cooled cheeses also developed significantly higher levels of lactic acid than did brine-cooled cheeses.
CSLM illumination for 1D and 2D encoded holographic 3D displays (2018)

To leave the path of classic holography and limit the space-bandwidth-product of the holographic reconstruction is one way to enable interactive real time holographic 3D displays. Thus, a couple of major problems - among several others - can be reduced to a practical level. This holds e.g. for the computation power, the data transfer rate and the pixel count of the spatial light modulator (SLM) used. Although this idea is almost twenty years old, the maximum time span of IP protection, displays based on space-bandwidth-limited CGH reconstruction, which also can be referred to as spacebandwidth- limited reconstruction of wave front segments, are still not on the market. There are several technological reasons for that. However, the technological barriers can be tackled gradually. One problem to be solved is the illumination of the entrance plane of the preferable complex valued spatial light modulator (CSLM). Here, CSLM means to modulate the phase and the amplitude of each pixel. The display diagonals of desktop and TV type CSLM might be e.g. 32 and 65 inch respectively. In other words, reasonable large collimated illumination wave fields are mandatory. In addition a small form factor is a must have in order to obtain commercial success. The solution is an optical system design, which is based on Bragg diffraction based volume gratings. Classic refractive optics fails here. In other words, Bragg diffraction based volume gratings are key components of illumination units of holographic 3D displays. They can be used within a parameter space, which cannot be addressed by surface relief type diffraction optics. But their layout depends on the parameters of the illumination wave field, which has to be tailored in regards to the optical system of the discrete, e.g. 1D or 2D encoded holographic 3D display. This will be described in more detail. The example used for the description is a double wedge type backlight unit. Furthermore, it will be explained why the use of complex valued secondary light sources is a must have in holographic 3D displays. For this, a short explanation of coherent retinal inter object point cross talk will be given too. Finally, the description of the wave field shaping (WFS), which is required in order to form the optimized complex valued light source planes, is provided. In other words, a description of a tailored coherence preparation is given, which is up to now not state of the art. The cause and effect relationship of the light propagating from the primary light sources, which are lasers, to the final receptor, which is the retina, will be pointed out. Although this tailored partial coherent illumination totally differs from the state of the art of information displays, it might help to understand a technology, which will come in the next decades.
Prelingual Deafness: High Prevalence of a 30delG Mutation in the Connexin 26 Gene (1997)

Prelingual non-syndromic (isolated) deafness is the most frequent hereditary sensory defect. In >80% of the cases, the mode of transmission is autosomal recessive. To date, 14 loci have been identified for the recessive forms (DFNB loci). For two of them, DFNB1 and DFNB2, the genes responsible have been characterized; they encode connexin 26 and myosin VIIA, respectively. In order to evaluate the extent to which the connexin 26 gene (Cx26) contributes to prelingual deafness, we searched for mutations in this gene in 65 affected Caucasian families originating from various countries, mainly tunisia, France, New Zealand and the UK. Six of these families are consanguineous, and deafness was shown to be linked to the DFNB1 locus, 10 are small non consanguineous families in which the segregation of the trait has been found to be compatible with the involvement of DFNB1, and in the remaining 49 families no linkage analysis has been performed. A total of 62 mutant alleles in 39 families were identified. Therefore, mutations in Cx26 represent a major cause of recessively inherited prelingual deafness since according to the present results they would underlie approximately half of the cases. In addition, one specific mutation, 30delG, accounts for the majority (approximately 70%) of the Cx26 mutant alleles. It is therefore one of the most frequent disease mutations so far identified. Several lines of evidence indicate that the high prevalence of the 30delG mutation arises from a mutation hot spot rather than from a founder effect. Genetic counseling for prelingual deafness has been so far considerably impaired by the difficulty in distinguishing genetic and non genetic deafness in families presenting with a single deaf child. Based on the results presented here, the development of a simple molecular test could be designed which should be of considerable help.
Performance of a New Biodegradable Ester Based Lubricant for Improving Drilling Operations with Water Based Muds (1997)

Abstract The development of new drilling technologies like extended reach drilling (ERD) or slimhole drilling and the reinforcement of environmental legislations require new adaptation of water based formulations. Good lubricating properties of the mud that would minimize any risk of differential pressure sticking of the pipe are of major impact on the efficiency of drilling operations. A biodegradable and non toxic ester based lubricating formulation has been developed that significantly reduces torque and pipe drag. Efficiency of the lubricant has been confirmed by an extensive testing under strictly controlled laboratory conditions simulating actual drilling conditions. The lubricant is very efficient on many different water based formulations, even containing high content of salts or solids, cases where classical lubricants are usually poorly efficient. The ester based lubricant is also very efficient for low solids formulations used for slimhole drilling. It is readily dispersible in water based muds and does not affect mud rheology nor filtration behavior nor any other mud property; in some cases its addition may even improve the filtrate loss reduction. Furthermore this highly efficient additive is completely biodegradable and non ecotoxic. Field tests carried out in Africa, north sea and US have largely confirmed the laboratory results presenting, for instance, a torque reduction of more than 40%. Introduction Environmental constraints concerning drilling fluids require new formulations that are non toxic for replacing mineral oil based muds. Water based muds are good candidates but new drilling conditions (deep drilling, slimhole drilling, extended reach drilling, multilateral drains) rise specific technical problems in particular concerning lubrication and risk of differential pressure sticking. When drilling long sections of highly deviated wells large friction between the drill pipe and the wall will increase torque and power required to rotate the drill pipe and the stress on the drill pipe. It could also interfere with running the pipe in and out of the hole. As a consequence good lubricating properties of the mud will improve greatly drilling operation efficiency. An joint research programme has been undertaken by IFP and FINA for developing a new performant and non toxic lubricant in order to increase drilling rates in operations using water based muds. The major goal set forward when starting the ester based lubricant R and D programme was to achieve superior performance combined with full ecological and human safety. This paper describes extensive laboratory tests and also results from field tests showing the performances of the ester based lubricant for reducing torque and pipe drag when using water based muds. P. 539^
Fast Compression of OFDM Channel State Information with Constant Frequency Sinusoidal Approximation (2017)

We propose CSIApx, a very fast and lightweight method to compress the Channel State Information (CSI) of Wi-Fi networks. CSIApx approximates the CSI vector as the linear combination of a small number of base sinusoids on constant frequencies, and uses the complex coefficients of the base sinusoids as the compressed CSI. While it is well- known that the CSI vector can be represented as the linear combination of sinusoids, fixing the frequencies of the base sinusoids is the key novelty of CSIApx, which is guided by our mathematical finding that almost any sinusoid can be approximated by the same set of base sinusoids with small bounded error. CSIApx enjoys very low computation complexity, because the key steps in the compression can be pre-computed. We extensively test CSIApx with both experimental and synthesized Wi-Fi channel data, and the results confirm that CSIApx can achieve very good compression ratio with little loss of accuracy.
Third-order optical autocorrelator for time-domain operationat telecommunication wavelengths (2004)

We report on amorphous organic thin films that exhibit efficient third-harmonic generation at telecommunication wavelengths. At 1550nm, micrometer-thick samples generate up to 17μW of green light with input power of 250mW delivered by an optical parametric oscillator. This high conversion efficiency is achieved without phase matching or cascading of quadratic nonlinear effects. With these films, we demonstrate a low-cost, sensitive third-order autocorrelator that can be used in the time-frequency domain.
Continuous Hydrogen Photoproduction by Chlamydomonas reinhardtii (2005)

This study demonstrates, for the first time, that it is possible to couple sulfate-limited Chlamydomonas reinhardtii growth to continuous H2 photoproduction for more than 4000 h. A two-stage chemostat system physically separates photosynthetic growth from H2 production, and it incorporates two automated photobioreactors (PhBRs). In the first PhBR, the algal cultures are grown aerobically in chemostat mode under limited sulfate to obtain photosynthetically competent cells. Active cells are then continuously delivered to the second PhBR, where H2 production occurs under anaerobic conditions. The dependence of the H2 production rate on sulfate concentration in the medium, dilution rates in the PhBRs, and incident light intensity is reported.
Layered Double Hydroxide Supported Nanopalladium Catalyst for Heck‐, Suzuki‐, Sonogashira‐, and Stille‐Type Coupling Reactions of Chloroarenes. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Study of a Novel Solvent System for CO2 Capture from Post-Combustion Flue Gas (2014)

CAER-S2 solvent system developed in the Center for Applied Energy Center at the University of Kentucky has the advantages of fast CO2 removal rate, high thermal stability, low volatility, and commercial quantity available. Vapor liquid equilibrium measurement shows that the solvent has a lower partial pressure than that of MEA at scrubber temperatures. Such feature makes the solvent a promising candidate for carbon capture from natural gas-fired flue gas which has low CO2 concentration. Mass transfer coefficients of CO2 in the solvent system are tested using a wetted-wall column with simulated gases at the scrubber condition. Experimental results indicate that the mass transfer coefficient increases with the increasing of temperature over the studied range, which is different from the studies on MEA. Such results suggest that the solvent is preferable to be operated at elevated temperature in scrubber at which physical mass transfer limitation is minimized without sacrificing too much driving force.
Inactivation of p53 Function in Cultured Human Mammary Epithelial Cells Turns the Telomere-Length Dependent Senescence Barrier from Agonescence into Crisis (2007)

Cultured human mammary epithelial cells (HMEC) encounter two distinct barriers to indefinite growth. The first barrier, originally termed selection, can be overcome through loss of expression of the cyclin-dependent kinase inhibitor p16(INK4A). The resultant p16-, p53+ post-selection HMEC encounter a second barrier, termed agonescence, associated with critically shortened telomeres and widespread chromosomal aberrations. Although some cell death is present at agonescence, the majority of the population retains long-term viability. We now show that abrogation of p53 function in post-selection HMEC inactivates cell cycle checkpoints and changes the mostly viable agonescence barrier into a crisis-like barrier with massive cell death. In contrast, inactivation of p53 does not affect the ability of HMEC to overcome the first barrier. These data indicate that agonescence and crisis represent two different forms of a telomere-length dependent proliferation barrier. Altogether, our data suggest a modified model of HMEC senescence barriers. We propose that the first barrier is Rb-mediated and largely or completely independent of telomere length. This barrier is now being termed stasis, for stress-associated senescence. The second barrier (agonescence or crisis) results from ongoing telomere erosion leading to critically short telomeres and telomere dysfunction.
Synthesis and structure-activity relationships of new 7-[3-(fluoromethyl)piperazinyl]- and -(fluorohomopiperazinyl)quinolone antibacterials (1990)

Some novel 6-fluoro-7-substituted-1,4-dihydro-4-oxoquinoline-3-carboxylic acids have been prepared. At the N-1 position "standard" substitution was employed with the ethyl, cyclopropyl, and p-fluorophenyl groups being used. At C-7 the introduction of some novel piperazines was made. Most notably, 2-(fluoromethyl)piperazine (10) and hexahydro-6-fluoro-1H-1,4-diazepine (16, fluorohomopiperazine) at the quinolone C-7 position produced products with similar in vitro antibacterial activity as the ciprofloxacin reference. The in vivo efficacy of 1-cyclopropyl-6-fluoro-7-[3-(fluoromethyl)piperazinyl]-1,4-dihydro-4- oxoquinoline-3-carboxylic acid (20) was excellent with better oral absorption than ciprofloxacin (2).
Immediate and delayed transplantation of mesenchymal stem cells improve muscle force after skeletal muscle injury in rats (2012)

Mesenchymal stem cell (MSC) therapy is a promising approach for regaining muscle function after trauma. Prior to clinical application, the ideal time of transplantation has to be determined. We investigated the effects of immediate and delayed transplantation. Sprague-Dawley rats received a crush trauma to the left soleus muscle. Treatment groups were transplanted locally with 2 × 10(6) autologous MSCs, either immediately or 7 days after trauma. Saline was used as sham therapy. Contraction force tests and histological analyses were performed 4 weeks after injury. GFP-labelled MSCs were followed after transplantation. The traumatized soleus muscles of the sham group displayed a reduction of twitch forces to 36 ± 17% and of tetanic forces to 29 ± 11% of the non-injured right control side, respectively. Delayed MSC transplantation resulted in a significant improvement of contraction maxima in both stimulation modes (twitch, p = 0.011; tetany, p = 0.014). Immediate transplantation showed a significant increase in twitch forces to 59 ± 17% (p = 0.043). There was no significant difference in contraction forces between muscles treated by immediate and delayed cell transplantation. We were able to identify MSCs in the interstitium of the injured muscles up to 4 weeks after transplantation. Despite the fundamental differences of the local environment, which MSCs encounter after transplantation, similar results could be obtained with respect to functional muscle regeneration. We believe that transplanted MSCs residing in the interstitial compartment evolve their regenerative capabilities through paracrine pathways. Our data suggest a large time window of the therapeutical measures.