gebhart/patrepeval huggingface dataset:
Insect cytochrome <i>P</i>-450: metabolism and resistance to insecticides (1993)

Conference Article| November 01 1993 Insect cytochrome P-450: metabolism and resistance to insecticides Ernest Hodgson; Ernest Hodgson *Department of Toxicology, Box 7633, North Carolina State University, Raleigh, NC 27695, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Randy L. Rose; Randy L. Rose *Department of Toxicology, Box 7633, North Carolina State University, Raleigh, NC 27695, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Doreen K. S. Goh; Doreen K. S. Goh †Department of Entomology, Box 7633, North Carolina State University, Raleigh, NC 27695, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar George C. Rock; George C. Rock †Department of Entomology, Box 7633, North Carolina State University, Raleigh, NC 27695, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar R. Michael Roe R. Michael Roe †Department of Entomology, Box 7633, North Carolina State University, Raleigh, NC 27695, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (4): 1060–1065. https://doi.org/10.1042/bst0211060 Article history Received: August 13 1993 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Ernest Hodgson, Randy L. Rose, Doreen K. S. Goh, George C. Rock, R. Michael Roe; Insect cytochrome P-450: metabolism and resistance to insecticides. Biochem Soc Trans 1 November 1993; 21 (4): 1060–1065. doi: https://doi.org/10.1042/bst0211060 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
ChemInform Abstract: Regioselective Silyl/Acetate Exchange of Disaccharides Yields Advanced Glycosyl Donor and Acceptor Precursors. (2014)

Abstract Acid concentration, thermal conditions, and microwave assistance mediate the silyl/acetate exchange reaction.
Molten salt destruction of energetic material wastes as an alternative to open burning. Revision 1 (1994)

As a result of the end of the Cold War and the shift in emphasis to a smaller stockpile, many munitions, both conventional and nuclear, are scheduled for retirement and rapid dismantlement and demilitarization. Major components of these munitions are the explosives and propellants, or energetic materials. The Molten Salt Destruction (MSD) Process has been demonstrated for the destruction of HE and HE-containing wastes. MSD converts the organic constituents of the waste into non-hazardous substances such as carbon dioxide, nitrogen and water. Any inorganic constituents of the waste, such as binders and metallic particles, are retained in the molten salt. LLNL has built a small-scale (about 1 kg/hr throughput) unit to test the destruction of HE using the MSD process. The authors have demonstrated that HE`s and liquid propellants can be safely and fully destroyed using the molten salt destruction process. The authors are currently working on a number of improvements to the process. They are modifying the design of unit to obtain more throughput without any increase in salt entrainment. They are implementing an advanced nozzle design for injection of larger particles. They are defining operating envelopes for a number of high explosives and formulations. They are developing models to study the temperature profile of a top-feed nozzle for feeding larger particles into the unit.
A Uve1p-Mediated Mismatch Repair Pathway in<i>Schizosaccharomyces pombe</i> (1999)

UV damage endonuclease (Uve1p) from Schizosaccharomyces pombe was initially described as a DNA repair enzyme specific for the repair of UV light-induced photoproducts and proposed as the initial step in an alternative excision repair pathway. Here we present biochemical and genetic evidence demonstrating that Uve1p is also a mismatch repair endonuclease which recognizes and cleaves DNA 5' to the mispaired base in a strand-specific manner. The biochemical properties of the Uve1p-mediated mismatch endonuclease activity are similar to those of the Uve1p-mediated UV photoproduct endonuclease. Mutants lacking Uve1p display a spontaneous mutator phenotype, further confirming the notion that Uve1p plays a role in mismatch repair. These results suggest that Uve1p has a surprisingly broad substrate specificity and may function as a general type of DNA repair protein with the capacity to initiate mismatch repair in certain organisms.
Ultrasensitive excitation/relaxation calorimeter for simultaneous measurement of thermal conductivity and heat capacity in fluids (1998)

An ultrasensitive heat conduction microcalorimeter for fluids with a novel method of data analysis is described. The instrument measures the thermal conductivity (λ) and heat capacity (Cp) simultaneously on the same sample with a resolution of 1 part in 105 for each of these properties. Baseline and sample filling errors are below the instrument resolution. The accuracies for λ and Cp are approximately 1 part in 104, limited primarily by the uncertainty in the properties of the standards used for calibration. The instrument operates essentially isothermally, and is capable of automated temperature stepping between 5 and 55 °C.
Synthesis and Biological Activity of Potent HIV-1 Protease Inhibitors Based on Phe-Pro Dihydroxyethylene Isosteres (2012)

Peptidomimetic inhibitors of HIV-1 PR are still a key resource in the fight against AIDS. Here we describe the synthesis and biological activity of HIV-1 PR inhibitors based on four novel dihydroxyethylene isosteres of the Phe-Pro and Pro-Pro dipeptides. The isosteres, containing four stereogenic centers, were synthesized in high yield and excellent stereoselectivity via the cyclization of epoxy amines derived from α-amino acids. The inhibitors were assembled by coupling the isosteres with suitable flanking groups and were screened against recombinant HIV PR showing activities in the subnanomolar to micromolar range. Two Phe-Pro-based inhibitors active at the nanomolar level were further investigated: both inhibitors combine the ability to suppress HIV-1 replication in infected MT-2 cells with low cytotoxicity against the same cells, thereby displaying a high therapeutic index. These results demonstrate the potential of the new Phe-Pro dihydroxyethylene isostere as a core unit of powerful HIV-1 PR inhibitors.
Optical polarization of <i>m</i> ‐plane In‐GaN/GaN light‐emitting diodes characterized via confocal microscope (2008)

Abstract A confocal microscope was applied to characterize near‐field optical polarization of light emission from InGaN‐based light‐emitting diodes prepared on a nonpolar orientation. Detection of stray light was significantly reduced as a result of the confocal technique compared to broad‐area measurements. The confocal measurement required no special sample preparation and obtained data was directly interpretable. A polarization ratio of 0.83 was measured on long‐wavelength emitting devices and was sustained over two orders of magnitude of low current range. Energy shifts and separation of emission peaks for the two polarization components were evaluated to discuss the valence‐band structure. Energy shifts indicated that the topmost band | X 〉 had a heavier effective mass than the lower band | Z 〉. Splitting energy of InGaN was estimated to be 30 meV. Results were consistent with the past reports, thus it was confirmed that the confocal microscope is a valid technique to characterize near‐field optical polarization. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Germacrene C synthase from<i>Lycopersicon esculentum</i>cv. VFNT Cherry tomato: cDNA isolation, characterization, and bacterial expression of the multiple product sesquiterpene cyclase (1998)

Germacrene C was found by GC-MS and NMR analysis to be the most abundant sesquiterpene in the leaf oil of Lycopersicon esculentum cv. VFNT Cherry, with lesser amounts of germacrene A, guaia-6,9-diene, germacrene B, beta-caryophyllene, alpha-humulene, and germacrene D. Soluble enzyme preparations from leaves catalyzed the divalent metal ion-dependent cyclization of [1-3H]farnesyl diphosphate to these same sesquiterpene olefins, as determined by radio-GC. To obtain a germacrene synthase cDNA, a set of degenerate primers was constructed based on conserved amino acid sequences of related terpenoid cyclases. With cDNA prepared from leaf epidermis-enriched mRNA, these primers amplified a 767-bp fragment that was used as a hybridization probe to screen the cDNA library. Thirty-one clones were evaluated for functional expression of terpenoid cyclase activity in Escherichia coli by using labeled geranyl, farnesyl, and geranylgeranyl diphosphates as substrates. Nine cDNA isolates expressed sesquiterpene synthase activity, and GC-MS analysis of the products identified germacrene C with smaller amounts of germacrene A, B, and D. None of the expressed proteins was active with geranylgeranyl diphosphate; however, one truncated protein converted geranyl diphosphate to the monoterpene limonene. The cDNA inserts specify a deduced polypeptide of 548 amino acids (Mr = 64,114), and sequence comparison with other plant sesquiterpene cyclases indicates that germacrene C synthase most closely resembles cotton delta-cadinene synthase (50% identity).
Statistical learning techniques for costing XML queries (2005)

Developing cost models for query optimization is significantly harder for XML queries than for traditional relational queries. The reason is that XML query operators are much more complex than relational operators such as table scans and joins. In this paper, we propose a new approach, called Comet, to modeling the cost of XML operators; to our knowledge, Comet is the first method ever proposed for addressing the XML query costing problem. As in relational cost estimation, Comet exploits a set of system catalog statistics that summarizes the XML data; the set of &quot;simple path&quot; statistics that we propose is new, and is well suited to the XML setting.
<title>Comparison of different imaging modes for scanning laser ophthalmoscopes</title> (2000)

We describe a bench top system for digital scanning laser ophthalmoscopy. This system is used for both regular patient screening and experimental imaging studies. The complete set- up is assembled from a number of modules (e.g. launching, detection, scanning, focusing unit) which may be altered readily to offer a high degree of flexibility in the imaging conditions. Both the launching and the detection unit can be used in a simultaneous, multiple channel configuration. This allows the acquisition of true color and false color images of the back of the eye. In particular, the use of infrared lines permits the investigation of deeper retinal structures. Digital image processing methods can then be used to generate differential images of frames taken with different wavelengths, such as red and infrared. Furthermore, the separate detection channels can also be used to obtain recordings in other imaging modes, such as tightly confocal, loosely confocal, indirect or polarization dependent contrast. We discuss the merits and problems of different imaging modes. Cases are presented where the differential imaging shows clear advantages over the standard (monochromatic) confocal method in the perceptibility of deeper laying structures (choriod).
Gaze-Contingent Music Reward Therapy for Social Anxiety Disorder: A Randomized Controlled Trial (2017)

This is the first randomized controlled trial to examine a gaze-contingent intervention in social anxiety disorder. The results demonstrate target engagement and clinical effects. This study sets the stage for larger randomized controlled trials and testing in other emotional disorders.
A Water-Soluble Luminescence Oxygen Sensor (1998)

We developed a water-soluble luminescent probe for dissolved oxygen. This probe is based on (Ru[dpp(SO3Na)2]3) cl2, which is a sulfonated analogue of the well-known oxygen probe (Ru[dpp]3)cl2. The compound dpp is 4,7-diphenyl-1,10-phenanthroline and dpp(SO3Na)2 is a disulfonated derivative of the same ligand. In aqueous solution in the absence of oxygen (Ru[dpp(SO3Na)2]3)cl2 displays a lifetime of 3.7 microseconds that decreases to 930 ns on equilibrium with air and 227 ns on equilibrium with 100% oxygen. The Stern-Volmer quenching constant is 11,330 M-1. This high oxygen-quenching constant means that the photoluminescence of Ru(dpp[SO3Na]2)3cl2 is 10% quenched at an oxygen concentration of 8.8 x 10(-6) M, or equilibration with 5.4 torr of oxygen. The oxygen probe dissolved in water displays minimal interactions with lipid vesicles composed of dipalmityl-L-alpha-phosphatidyl glycerol but does appear to interact with human serum albumin. The absorption maximum near 480 nm, long lifetime and large Stokes' shift allow this probe to be used with simple instrumentation based on a light-emitting diode light source, allowing low-cost oxygen sensing in aqueous solutions. To the best of our knowledge this is the first practical water-soluble oxygen sensor.
Coherent resonant Ka-band photonic microwave receiver (2008)

We propose theoretically and demonstrate experimentally a coherent microwave photonic receiver operating at 35 GHz carrier frequency. The device is based on a lithium niobate or lithium tantalate optical whispering gallery mode resonator coupled to a microwave strip line resonator. Microwave local oscillator is fed into the microwave resonator along with the microwave signal. We show that the sensitivity of this receiver significantly exceeds the sensitivity of the incoherent quadratic receiver based on the same technology. The coherent receiver can possess a dynamic range in excess of 100 dB in 5 MHz band if a low noise laser is utilized.
Electrical Behavior of Phase-Change Memory Cells Based on GeTe (2010)

In this letter, we present a study on the electrical behavior of phase-change memories (PCMs) based on a GeTe active material. GeTe PCMs show, first, extremely rapid SET operation (yielding a gain of more than one decade in energy per bit with respect to standard GST PCMs), second, robust cycling, up to 1 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> , with 30-ns SET and RESET stress time, and third, a better retention behavior at high temperature with respect to GST PCMs. These results, obtained on single cells, suggest GeTe as a promising alternative material to standard GST to improve PCM performance and reliability.
Cathodoluminescence mapping of epitaxial lateral overgrowth in gallium nitride (1999)

The dislocation arrangements in gallium nitride (GaN) films prepared by lateral epitaxial overgrowth (LEO) have been studied by cathodoluminescence mapping and transmission electron microscopy. A very low density of electrically active defects (&lt;10−6 cm−2) in the laterally overgrown material is observed. Individual electrically active defects have been observed that propagate laterally from the line of stripe coalescence into the overgrown material. Additionally, by mapping wavelength-resolved luminescence in an InGaN quantum well grown on top of the overgrown material, these defects are shown to be limited to the underlying material and do not propagate normal to the surface, as in other GaN films. In the seed region, threading dislocation image widths are seen to be nearly identical in the quantum well and the underlying GaN, indicating a comparable upper limit (∼200 nm) for minority carrier diffusion length in InGaN and GaN. Additionally, it is shown that, through processing variation, these lateral defects can be avoided in LEO films and that wavelength-resolved cathodoluminescence is an excellent large-area method for rapidly and quantitatively observing variations in process development.
3D printed droplet generation devices for serial femtosecond crystallography enabled by surface coating (2019)

The role of surface wetting properties and their impact on the performance of 3D printed microfluidic droplet generation devices for serial femtosecond crystallography (SFX) are reported. SFX is a novel crystallography method enabling structure determination of proteins at room temperature with atomic resolution using X-ray free-electron lasers (XFELs). In SFX, protein crystals in their mother liquor are delivered and intersected with a pulsed X-ray beam using a liquid jet injector. Owing to the pulsed nature of the X-ray beam, liquid jets tend to waste the vast majority of injected crystals, which this work aims to overcome with the delivery of aqueous protein crystal suspension droplets segmented by an oil phase. For this purpose, 3D printed droplet generators that can be easily customized for a variety of XFEL measurements have been developed. The surface properties, in particular the wetting properties of the resist materials compatible with the employed two-photon printing technology, have so far not been characterized extensively, but are crucial for stable droplet generation. This work investigates experimentally the effectiveness and the long-term stability of three different surface treatments on photoresist films and glass as models for our 3D printed droplet generator and the fused silica capillaries employed in the other fluidic components of an SFX experiment. Finally, the droplet generation performance of an assembly consisting of the 3D printed device and fused silica capillaries is examined. Stable and reproducible droplet generation was achieved with a fluorinated surface coating which also allowed for robust downstream droplet delivery. Experimental XFEL diffraction data of crystals formed from the large membrane protein complex photosystem I demonstrate the full compatibility of the new injection method with very fragile membrane protein crystals and show that successful droplet generation of crystal-laden aqueous droplets intersected by an oil phase correlates with increased crystal hit rates.
Design and Evaluation of a Stand-Up Motorized Prone Cart (2007)

This prone cart design is an improvement over the standard, flat variety. However, further design changes will be necessary. This study provided valuable information that will be useful in the next-generation prone cart design project.
High-repetition-rate far-infrared p-Ge laser (1996)

FIR/sub-mm laser emission (70 to 250 micron) from p-Ge in E ⊥ B fields is enhanced when Voigt configuration is used. It was recently demonstrated that permanent magnets provide an easier realization of the Voigt configuration than do the traditional superconducting solenoids. This paper reports an additional advantage resulting from the relatively open permanent magnet architecture.
Oxidation process concept to produce lignin dispersants at a kraft pulp mill (2022)

Abstract This paper presents the concept of an alkali-O 2 oxidation process for producing lignin dispersants in a feasible manner at a kraft pulp mill. The oxidation process uses O 2 gas to increase the anionic charge of lignin and the final oxidised lignin can serve as a concrete plasticiser or versatile dispersant. The integrated process provides several benefits for lignin recovery, the following lignin oxidation, and recycling of chemicals. Firstly, CO 2 precipitated kraft lignin can be used without a sulphuric acid washing step. This simplifies the lignin recovery and no excess sulphur is introduced into mill cycle. As the unwashed lignin is alkaline in nature, the need for fresh alkali in the lignin oxidation is reduced. Moreover, oxidised white liquor, readily available in the mill, can be applied as a partial source of alkali. Finally, membrane filtration of the oxidised lignin solution enables the recirculation of sodium and sulphur back to the chemical cycle and provides a concentrated lignin product. Based on a simulation study, this novel concept significantly decreased the need for purging fly ash at the mill when compared to conventional lignin recovery. It was also demonstrated that the novel lignin dispersants can compete with the tested commercial oil-based plasticisers.
Genistein aglycone reverses glucocorticoid‐induced osteoporosis and increases bone breaking strength in rats: a comparative study with alendronate (2009)

The results strongly suggest that the genistein aglycone might be an alternative therapy for the management of secondary osteoporosis.
<title>Vibration analysis in simply supported cable using weighted optical fiber sensors</title> (1994)

This paper discusses a first step in the use of weighted optical fiber sensors to selectively determine the mode shape amplitudes of different vibration modes in a simply supported cable. A weighted fiber sensor has a sensitivity function that varies along the length of the fiber. To date, such weighted sensitivity fibers have been fabricated by either writing spatially chirped refractive index gratings in two-mode elliptical-core fiber or by geometrically tapering single mode or two-mode elliptical core fiber. The output signal from the fiber sensor system is proportional to the weighted integral of strain along the length of the fiber, and subsequent analysis indicates that this yields a measure of only one selected mode.
Computer verification of fluence map for intensity modulated radiation therapy (2000)

In a treatment planning system for intensity modulated radiation therapy (IMRT), the time sequence of multileaf collimator (MLC) settings are derived from an optimal fluence map as a postoptimization process using a software module called a "leaf sequencer." The dosimetric accuracy of the dynamic delivery depends on the functionality of the module and it is important to verify independently the correctness of the leaf sequences for each field of a patient treatment. This verification is unique to the IMRT treatment and has been done using radiographic film, electronic portal imaging device (EPID) or electronic imaging system (BIS). The measurement tests both the leaf sequencer and the dynamic multileaf collimator (MLC) delivery system, providing a reliable assurance of clinical IMRT treatment. However, this process is labor intensive and time consuming. In this paper, we propose to separate quality assurance (QA) of the leaf sequencer from the dynamic MLC delivery system. We describe a simple computer algorithm for the verification of the leaf sequences. The software reads in the leaf sequences and simulates the motion of the MLC leaves. The generated fluence map is then compared quantitatively with the reference map from the treatment planning system. A set of pre-defined QA indices is introduced to measure the "closeness" between the computed and the reference maps. The approach has been used to validate the CORVUS (NOMOS Co., Sewickley, PA) treatment plans. The results indicate that the proposed approach is robust and suitable to support the complex IMRT QA process.