gebhart/patrepeval huggingface dataset:
Assessment of menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders (1999)

Menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders were assessed in this study. One hundred and sixteen women, including 66 with von Willebrand's disease (vWD), 30 carriers of haemophilia and 20 with factor XI (FXI) deficiency were interviewed and their gynaecological history obtained. Their case records were also reviewed and menstrual loss was objectively assessed using a pictorial blood assessment chart (PBAC). Comparison with an age-matched control group (69 women) was performed. Menorrhagia (PBAC score> 100) was confirmed in 74%, 57% and 59% of women with vWD, carriers of haemophilia and FXI deficiency, respectively, in comparison with 29% in the control group (P = 0.001). PBAC scores were higher in vWD patients with a von Willebrand factor activity (vWF:Ac) of </= 30 IU dL-1 compared to those with higher levels, but the difference was not statistically significant. However, there was no relation between PBAC score and the severity of the disease in FXI deficient patients and carriers of haemophilia. Duration of menstruation was significantly longer (P = 0.001) and episodes of flooding was significantly more common (P = 0.001) in patients with inherited bleeding disorders compared to the control group. However, there was no difference in the passage of clots during menstruation. Forty-seven per cent of patients with inherited bleeding disorders had consultations with their family practitioner or gynaecologist for menorrhagia, 36% had medical treatment and 27% had surgical procedures, including 10 hysterectomies. Post-operative bleeding followed in four out of 28 cases of hysteroscopy and/or dilatation and curettage. Bleeding complications following hysterectomy were reported in five out of 10 patients. In conclusion, menorrhagia is a common and major problem in patients with inherited bleeding disorders, especially vWD. Increased awareness among gynaecologists and haematologists of the high prevalence of menorrhagia and the treatment options available is necessary for optimal management of these patients. Appropriate preoperative assessment and haemostatic control during any gynaecological procedure, however minor, and in collaboration with the local haemophilia centre is essential to minimize risks of haemorrhagic complications.
Three-Dimensional Pattern Drafting (1990)

An algorithm for computationally drafting garment patterns from three-dimensional data is presented. A functional relationship for the garment definition step of an earlier theoretical framework is developed for a basic skirt. The three-dimensional form of an individually fitted skirt is modeled using this relationship and then projected, using the method developed in Part I, to produce a two-dimensional pattern. Previously reported methods for drafting garment patterns from three-dimensional data have combined the garment definition and projection steps; this has restricted the form of the garment that can be produced. In our method, the only factors that place restrictions on the form of the garment are the physical characteristics of the fabric from which the garment will be sewn, the figuration of the body, and the cultural definition of the garment.
A 512Mb phase-change memory (PCM) in 90nm CMOS achieving 2b/cell (2011)

The PCM memory chip demonstrates the key features for MLC on a relevant scale (256Mcells). Given its versatility in terms of programming pulse shape and timing, closed?loop algorithms, and the wide cell resistance range that the ADC can accommodate, the chip also appears as an ideal characterization tool in the development of PCM technology for nonvolatile MLC. For example, the flexibility allows the on-chip exploration of drift?resilient schemes, critical for MLC. In addition to its capability for technology benchmarking, the chip also serves as a template for future PCM memory chips targeting more than 2b/cell by introducing key circuit blocks such as fast BL voltage regulator and ADC auto range. We acknowledge the support of the entire PCM team at IBM.[1]C. Villa, ISSCC 2010. [2]G. De Sandre, ISSCC 2010. [3]I.S. Kim, Symp. VLSI Tech. 2010. [4]D.H. Kang, Symp. VLSI Tech. 2008. [5]R.F. Freitas, et al., IBM J. Res. & Dev. 2008. [6]A. Pantazi , EPCOS 2009. [7]G.F. Close, IEDM 2010. 19–4
Impact of barrier integrity on liner reliability in 3D through silicon vias (2013)

For 3D chip stacking using Cu through silicon vias (TSV's), dielectric liner reliability is crucial and is closely related to the barrier integrity. In this study, two different Cu barriers are compared in terms of dielectric liner reliability. By using two stress modes, where different voltage polarities are applied to the TSV, the impact of barrier integrity on liner reliability is segregated and PVD Ti is shown to be superior to PVD Ta for our particular liner. The field acceleration factors are extracted using classical TDDB and from controlled ramp rates, where a good match is found between the two methods. When applying a positive voltage to the TSV during stress, a bimodal distribution of the TDDB lifetime is observed for the PVD Ta barrier. This is linked to a competition between Cu induced dielectric breakdown and intrinsic dielectric breakdown.
Metal stents placement for refractory pancreatic duct stricture in children (2018)

This initial experience showed that temporary FCSEMS placement is feasible and safe for the management of refractory benign MPD stricture in children.
Electronically reconfigurable complex oxide heterostructure freestanding membranes (2021)

In recent years, lanthanum aluminate/strontium titanate (LAO/STO) heterointerfaces have been used to create a growing family of nanoelectronic devices based on nanoscale control of LAO/STO metal-to-insulator transition. The properties of these devices are wide-ranging, but they are restricted by nature of the underlying thick STO substrate. Here, single-crystal freestanding membranes based on LAO/STO heterostructures were fabricated, which can be directly integrated with other materials via van der Waals stacking. The key properties of LAO/STO are preserved when LAO/STO membranes are formed. Conductive atomic force microscope lithography is shown to successfully create reversible patterns of nanoscale conducting regions, which survive to millikelvin temperatures. The ability to form reconfigurable conducting nanostructures on LAO/STO membranes opens opportunities to integrate a variety of nanoelectronics with silicon-based architectures and flexible, magnetic, or superconducting materials.
Comparison of scoring methods used in speaker recognition with Joint Factor Analysis (2009)

The aim of this paper is to compare different log-likelihood scoring methods, that different sites used in the latest state-of-the-art Joint Factor Analysis (JFA) Speaker Recognition systems. The algorithms use various assumptions and have been derived from various approximations of the objective functions of JFA. We compare the techniques in terms of speed and performance. We show, that approximations of the true log-likelihood ratio (LLR) may lead to significant speedup without any loss in performance.
Identification of the bombesin receptor on murine and human cells by cross-linking experiments. (1987)

The bombesin receptor present on the surface of murine and human cells was identified using 125I-labeled gastrin-releasing peptide as a probe, the cross-linking agent disuccinimidyl suberate, and sodium dodecyl sulfate gels. A clone of NIH-3T3 cells which possesses approximately 80,000 bombesin receptors/cell with a single binding constant of approximately 1.9 X 10(-9) M was used in these studies. In addition, we used Swiss 3T3 cells and a human glioma cell line which possesses approximately 100,000 and approximately 55,000 bombesin receptors/cell, respectively. Under conditions found optimal for binding, it is demonstrated that 125I-labeled gastrin-releasing peptide can be cross-linked specifically to a glycoprotein of apparent molecular mass of 65,000 daltons on the surface of the NIH-3T3 cells. Similar results were obtained when the cross-linked product was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing or non-reducing conditions. Moreover, the cross-linking reaction is specific and saturable and the 65,000-dalton polypeptide is not observed when the cross-linking experiments were performed with a NIH-3T3 cell line which is devoid of bombesin receptors. Interestingly, glycoproteins with apparent molecular weights of 75,000 were labeled specifically by 125I-labeled gastrin-releasing peptide when similar experiments were performed with Swiss 3T3 cells and with human glioma cell line GM-340. These different molecular weights may indicate differential glycosylation as treatment with the enzyme N-glycanase reduced the apparent molecular weight of the cross-linked polypeptide to 45,000. On the basis of these results it is concluded that the cross-linked polypeptides represent the bombesin receptor or the ligand-binding subunit of a putative larger bombesin receptor expressed on the surface of these cells.
Spinal intradural, extramedullary anaplastic ependymoma with an extradural component: Case report and review of the literature (2011)

Even though spinal intradural extramedullary ependymomas are very rare, surgeons must be aware that on MRI, they can be mistaken for meningiomas or nerve sheath tumors especially if there is an extradural component. Our case report is the first intradural, extramedullary ependymoma that is anaplastic and has an extradural component. A review of the literature provides little information on the treatment and prognosis for these tumors especially if they are anaplastic. We propose that the treatment, as done in our case, should be complete resection of the tumor with spinal radiotherapy to the tumor level.
Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo (2010)

We have developed a dual bioluminescent reporter system allowing noninvasive, concomitant imaging of T-cell trafficking, expansion, and activation of nuclear factor of activated T cells (NFAT) in vivo. NFAT activation plays an important role in T-cell activation and T-cell development. Therefore we used this system to determine spatial-temporal activation patterns of (1) proliferating T lymphocytes during graft-versus-host disease (GVHD) and (2) T-cell precursors during T-cell development after allogeneic hematopoietic stem cell transplantation (HSCT). In the first days after HSCT, donor T cells migrated to the peripheral lymph nodes and the intestines, whereas the NFAT activation was dominant in the intestines, suggesting an important role for the intestines in the early stages of alloactivation during development of GVHD. After adoptive transfer of in vitro-derived T-cell receptor (TCR) H-Y transgenic T-cell precursors into B6 (H-2(b)) hosts of both sexes, NFAT signaling and development into CD4(+) or CD8(+) single-positive cells could only be detected in the thymus of female recipients indicating either absence of positive selection or prompt depletion of double-positive thymocytes in the male recipients. Because NFAT plays an important role in a wide range of cell types, our system could provide new insights into a variety of biologic processes.
Use of the directigen latex agglutination test for detection of Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis antigens in cerebrospinal fluid from meningitis patients (1984)

Cerebrospinal fluid specimens from 257 persons were tested for the presence of bacterial antigens by counterimmunoelectrophoresis and the Directigen meningitis test (Hynson, Westcott & Dunning, Div. Becton Dickinson & Co., Baltimore, Md.). The specimens were obtained from 162 patients with meningitis caused by Haemophilus influenzae type b, Streptococcus pneumoniae, or Neisseria meningitidis serogroups A and C and from 95 patients without bacterial meningitis or meningitis caused by other bacterial agents. Directigen detected H. influenzae type b antigen in 83% (69 of 83) of the specimens obtained from patients with H. influenzae disease, pneumococcal antigen in 77% (30 of 39) of the specimens from patients with pneumococcal disease, and N. meningitidis antigen in 93% (37 of 40) of the specimens from patients with disease caused by N. meningitidis serogroups A and C. The comparable figures for counterimmunoelectrophoresis were 66% (55 of 83), 79% (31 of 39), and 78% (31 of 40), respectively. No false-positive reactions were reported with the Directigen reagents. Nonspecific reactions (agglutination with more than one of the four Directigen latex reagents) were noted with five specimens. The nonspecific reactions were resolved in four of the five specimens by heating (100 degrees C for 3 min). The accumulated data demonstrate that the sensitivity of the Directigen meningitis test is better than or at least equivalent to the sensitivity of counterimmunoelectrophoresis for the detection of antigens in cerebrospinal fluid.
Curvelet based automatic segmentation of supraspinatus tendon from ultrasound image: a focused assistive diagnostic method (2014)

The segmentation of SSP tendon from ultrasound images helps in focused, accurate and more reliable diagnosis which has been verified with the help of two experienced radiologists. The specificity and sensitivity for accurate detection of partial and full thickness tears has been considerably increased after segmentation when compared with existing literature.
Dual pillar spin-transfer torque MRAMs for low power applications (2013)

Electron-spin based data storage for on-chip memories has the potential for ultra-high density, low power consumption, very high endurance, and reasonably low read/write latency. In this article, we discuss the design challenges associated with spin-transfer torque (STT) MRAM in its state-of-the-art configuration. We propose an alternative bit cell configuration and three new genres of magnetic tunnel junction (MTJ) structures to improve STT-MRAM bit cell stabilities, write endurance, and reduce write energy consumption. The proposed multi-port, multi-pillar MTJ structures offer the unique possibility of electrical and spatial isolation of memory read and write. In order to realize ultralow power under process variations, we propose device, bit-cell and architecture level design techniques. Such design alternatives at multiple levels of design abstraction has been found to achieve substantially enhanced robustness, density, reliability and low power as compared to their charge-based counterparts for future embedded applications.
Brain entropy, fractal dimensions and predictability: A review of complexity measures for EEG in healthy and neuropsychiatric populations (2022)

There has been an increasing trend towards the use of complexity analysis in quantifying neural activity measured by electroencephalography (EEG) signals. On top of revealing complex neuronal processes of the brain that may not be possible with linear approaches, EEG complexity measures have also demonstrated their potential as biomarkers of psychopathology such as depression and schizophrenia. Unfortunately, the opacity of algorithms and descriptions originating from mathematical concepts have made it difficult to understand what complexity is and how to draw consistent conclusions when applied within psychology and neuropsychiatry research. In this review, we provide an overview and entry-level explanation of existing EEG complexity measures, which can be broadly categorized as measures of predictability and regularity. We then synthesize complexity findings across different areas of psychological science, namely, in consciousness research, mood and anxiety disorders, schizophrenia, neurodevelopmental and neurodegenerative disorders, as well as changes across the lifespan, while addressing some theoretical and methodological issues underlying the discrepancies in the data. Finally, we present important considerations when choosing and interpreting these metrics.
Comparing frontal cranial profiles in archaic and modernHomo by morphometric analysis (1999)

Archaic and modern human frontal bones are known to be quite distinct externally, by both conventional visual and metric evaluation. Internally this area of the skull has been considerably less well-studied. Here we present results from a comparison of interior, as well as exterior, frontal bone profiles from CT scans of five mid-Pleistocene and Neanderthal crania and 16 modern humans. Analysis was by a new morphometric method, Procrustes analysis of semi-landmarks, that permits the statistical comparison of curves between landmarks. As expected, we found substantial external differences between archaic and modern samples, differences that are mainly confined to the region around the brow ridge. However, in the inner median-sagittal profile, the shape remained remarkably stable over all 21 specimens. This implies that no significant alteration in this region has taken place over a period of a half-million years or more of evolution, even as considerable external change occurred within the hominid clade spanning several species. This confirms that the forms of the inner and outer aspects of the human frontal bone are determined by entirely independent factors, and further indicates unexpected stability in anterior brain morphology over the period during which modern human cognitive capacities emerged. Anat Rec (New Anat): 257:217-224, 1999.
Hybrid secure random key pre-distribution scheme for wireless sensor networks (2007)

To achieve security in wireless sensor networks, it is important to be able to encrypt and authenticate messages sent among sensor nodes. Keys for encryption and authentication purposes must be agreed upon by communicating nodes. In this paper, we propose a new random pre-distribution key management scheme that meets the operational and security requirements of wireless sensor networks and provide authentication and key distribution in one set of protocols. Our scheme is substantially improves the resilience of the network compared to the existing schemes. The scheme is based a nice threshold property: when the number of compromised nodes is less than the threshold, the probability that any nodes other than these compromised nodes is affected is close to zero.
Tn<I>5</I> as a Molecular Genetics Tool: InVitro Transposition and the Coupling of In Vitro Technologies With In Vivo Transposition (2004)

The development of in vitro transposition technologies have provided many powerful tools for the molecular genetics research laboratory. In this chapter we describe some of these tools with a focus on the Tn5 transposition system. Tn5 technologies are particularly useful because the Tn5 transposition system has simple requirements, is efficient, random in target recognition, and robust. In particular we will describe the use of in vitro Tn5 transposition in transposon tagging and in the generation of nested deletions. We will also describe a unique in vitro/in vivo technology in which Tn5 inserts can be generated in a wide spectrum of bacterial species through the electroporation of preformed tranposase-transposon DNA complexes.
Effects of boron penetration and resultant limitations in ultra thin pure-oxide and nitrided-oxide gate-films (2002)

The boron penetration effect was compared for p/sup +/ poly gate PMOSFETs with pure oxide gates and nitrided oxide gates. For a gate thickness of 6.5 nm, reduced boron dosage and rapid thermal processing solve the problem of boron penetration in the pure oxide case. However, when the film thickness is less than 6.5 nm, only a nitrided oxide film can solve the problem. From the results of EDX analysis in nitrided oxide films, it was found that nitrogen build-up at the interface is small and that a nitrogen concentration of only a few percent leads to complete suppression of boron penetration down to the 2 nm range of film thickness. Excellent characteristics in 2.6 nm nitrided oxide gate p-MOSFETs, free from boron penetration effects, were demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Application of on-line inspection probe of machining center in free curve inspecting (2008)

This paper presents an on-line inspection system which integrates manufacturing together with inspection by equipping the machining center with touchable probe and corresponding inspection macro-programs. By this means, the machining center is provided with 3D measuring function, improved automatism and manufacturing quality. Although the on-line inspection system can implement some basic measuring tasks now, inspecting free curves is one of the significant applications for on-line inspection of machining center. For the inspection of free curves, this paper puts forward a new method that the curve inspecting and the path planning can be controlled with facility by manipulators using the on-line inspection technology for machining center aiming at the requirement of CAD modeling. Cube B-spline curve is adopted for inspecting path planning to acquire geometry information of the free curves. Through the method, a great deal of hits information about the curve is acquired and the manipulator can obtain idea points using few hits. It not only extends the function of the online inspection system for machining center, but also improves the product quality and the design efficiency simultaneously.
Characterization and Properties of Reactive Poly(lactic acid)/Polyamide 610 Biomass Blends (2013)

ABSTRACT A low molecular weight bisphenol‐A type epoxy resin was used as a reactive compatibilizer for poly(lactic acid) (PLA)/polyamide 610 (PA 610) biomass blends. To the best of our knowledge, this blend is the first biomass PA 610 blend in the literature. The epoxy functional groups could react with the terminal groups of both PLA and PA 610. An ester–amide interchange reaction led to a polyester–polyamide copolymer formation, and improved the compatibility of PLA and PA 610. The blends with epoxy resin showed an enhancement in the phase dispersion and interfacial adhesion compared with the blend without epoxy resin. The differential scanning calorimetry (DSC) analysis showed that the crystallization peak temperatures decreased with increasing epoxy content. The melting temperature of PA 610 decreased with the addition of PLA, but remained unchanged with increased compatibilizer dosages. The dynamic mechanical analysis (DMA) showed that the glass transition temperature ( T g ) of the blend, with the addition of 0.5 phr epoxy resin, slightly increased compared with that of neat PLA. However, the T g of the blends remained unchanged with increasing epoxy resin content, and the higher content of epoxy resin in the blends resulted in improved mechanical properties and higher melt viscosity. The unnotched impact test showed that PA 610 could toughen PLA with the addition of epoxy resin. Moreover, the no‐break unnotched impact behavior was observed with the medium content of the compatibilizer, improving the notch sensitivity of PLA. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 2563–2571, 2013