gebhart/patrepeval huggingface dataset:
8.1 nJ/b 2.4 GHz Short-Range Communication Receiver in 65 nm CMOS (2015)

An 8.1 nJ/bit 2.4 GHz receiver with integrated digital baseband supporting O-QPSK DSSS modulation compliant with the IEEE 802.15.4 standard is presented that targets short-range, Internet of Things applications (IoTs). The sensitivity of a wireless communication receiver in general trades with power consumption. This receiver exploits this tradeoff to achieve a total power consumption of 2.02 mW including ADCs and digital baseband processing, at a sensitivity of -52.5 dBm at 250 Kbps. The energy-efficiency of the radio frequency (RF) front-end alone is nearly 2x better than the prior art. The receiver was fabricated in 65 nm CMOS with an area of 0.86 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Universal Cloud Classification (UCC) and its Evaluation in a Data Center Environment (2014)

Classification ambiguity in Cloud Computing has a catastrophic impact on cloud providers, their services and tenants. It limits the application of various network services to traffic either inside or outside a cloud. This is because IP addresses, VLANs and other transport-level technologies lack the functionality to cope with the highly dynamic, scalable and virtualized environment of cloud-enabled data centers. In this paper, we present the prototype design and discuss its features. We also evaluate the UCC proposal in a cloud-enabled data center environment. Our examination of the compatibility, performance and usability of UCC shows that this scheme is not only feasible, easy to implement, but also has significant advantages over other classification techniques. For example, it enables highly desirable functionality such as traffic volume-based data center billing. Imminent follow-up efforts include scalability testing of UCC on the open Internet. We are confident the UCC scheme can provide a long-term, practical and flexible solution for cloud classification with significant benefits.
Filtered backprojection using algebraic filters; application to biomedical micro-CT data (2015)

For computerized tomography (CT) imaging in (bio)medical applications, radiation dose reduction is extremely important. This can be achieved simply by reducing the number of projection images taken. In order to obtain accurate reconstructions from few projections, however, common reconstruction techniques are not sufficient. Algebraic reconstruction methods (ARMs) are often more suited, but inflict a much higher computational burden. In this work, a recently proposed method is applied to biomedical μCT, in which the benefits of ARMs are combined with the computational efficiency of the common Filtered Backprojection (FBP) algorithm. Our experimental results demonstrate that this approach yields reconstructed images highly similar to those obtained by an ARM, while maintaining the favorable computational efficiency of FBP.
Realizing Wireless Cooperative Communications with the One-Bit Soft Forwarding Technique (2009)

To improve the efficiency and simplify the complexity of the relay in cooperative communication systems, an one-bit soft forwarding (SF) scheme is proposed to exploit the erroneously decoded packets that are normally abandoned by the selection decode-and-forward (DF) scheme at the relay, as side information to assist decoding of the direct-link packet at the base station. As this side information from relay is encoded and transmitted in the same format as the usual data packet, the proposed SF scheme can be implemented with the same coding scheme and same encoder/decoder as the DF scheme. It only requires the additional transmission of a packet reliability value from the relay to the basestation, unlike the previous soft relaying schemes which require more complicated soft output decoding and signaling format. The new scheme not only allows low complexity implementation, but also offers considerable error performance gain. Simulation results demonstrate that our SF scheme outperforms the selection DF by up to 2 dB, especially when the inter-link channel is poor.
Unsupervised learning for reranking-based patent retrieval (2010)

We present a reranking-based patent retrieval system where the query text is a patent claim, which may be from an existing patent. The novelty of our approach is the automatic generating of training data for learning the ranker. The ranking is based on several features of the candidate patent, such as the text similarity to the claim, international patent code overlap, and internal citation structure of the candidates. Our approach more than doubles the average number of relevant patents in the top 5 over a strong baseline retrieval system.
An edge‐readout, multilayer detector for positron emission tomography (2018)

A detector design based on a stack of monolithic scintillator layers that uses edge readouts offers several advantages over current block detectors for PET. For example, there is no tradeoff between spatial resolution and detection sensitivity since no reflector material displaces scintillator crystal, and submillimeter resolution can be achieved. DOI information is readily available, and excellent timing and energy resolutions are possible.
A low-complexity modeling approach for embedded coding of wavelet coefficients (2002)

We present a new low-complexity method for modeling and coding the bitplanes of a wavelet-transformed image in a fully embedded fashion. The scheme uses a simple ordering model for embedding, based on the principle that coefficient bits that are likely to reduce the distortion the most should be described first in the encoded bitstream. The ordering model is tied to a conditioning model in a way that deinterleaves the conditioned subsequences of coefficient bits, making them amenable to coding with a very simple, adaptive elementary Golomb (1966) code. The proposed scheme, without relying on zerotrees or arithmetic coding, attains PSNR vs. bit rate performance superior to that of SPIHT, and competitive with its arithmetic coding variant, SPIHT-AC.
RGB Emission through Controlled Donor Self‐Assembly and Modulation of Excitation Energy Transfer: A Novel Strategy to White‐Light‐Emitting Organogels (2009)

A white-light-emitting organogel is designed by the controlled self-assembly of a bischolesterol-functionalized OPV donor that allows slow energy migration and partial energy transfer in the gel state to an encapsulated acceptor. The white-light emission occurs because of the combination of blue-light emission from the OPV monomers, green-light emission from the OPV self-assembly, and red-light emission from the acceptor.
Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (2020)

Human T-cell leukemia virus type 1 (HTLV-1) causes incurable adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Patients with HAM/TSP have increased levels of HTLV-1-infected cells compared with asymptomatic HTLV-1 carriers. However, the roles of cellular genes in HTLV-1-infected CD4+ T cells await discovery. We performed microarray analysis of CD4+ T cells from HAM/TSP patients and found that the ABL1 is an important gene in HAM/TSP. ABL1 is a known survival factor for T- and B-lymphocytes and is part of the fused gene (BCR-ABL) known to be responsible for chronic myelogenous leukemia (CML). ABL1 tyrosine kinase inhibitors (TKIs), including imatinib, nilotinib, and dasatinib, are used clinically for treating CML. To evaluate whether ABL1 is indeed important for HAM/TSP, we investigated the effect of TKIs on HTLV-1-infected cells. We developed a propidium monoazide-HTLV-1 viability quantitative PCR assay, which distinguishes DNA from live cells and dead cells. Using this method, we were able to measure the HTLV-1 proviral load (PVL) in live cells alone when peripheral blood mononuclear cells (PBMCs) from HAM/TSP cases were treated with TKIs. Treating the PBMCs with nilotinib or dasatinib induced significant reductions in PVL (21.0% and 17.5%, respectively) in live cells. Furthermore, ABL1 siRNA transfection reduced cell viability in HTLV-1-infected cell lines, but not in uninfected cell lines. A retrospective survey based on our clinical records found a rare case of HAM/TSP who also suffered from CML. The patient showed an 84.2% PVL reduction after CML treatment with imatinib. We conclude that inhibiting the ABL1 tyrosine kinase specifically reduced the PVL in PBMCs from patients with HAM/TSP, suggesting that ABL1 is an important gene for the survival of HTLV-1-infected cells and that TKIs may be potential therapeutic agents for HAM/TSP.
Nonlinear Self-Filtering via Dynamical Stochastic Resonance (2008)

We experimentally demonstrate nonlinear self-filtering and amplification of low-light- level images hidden in noise. The observed effect strongly depends on the nonlinear coupling strength and properties of the noise, indicative of a dynamical stochastic resonance.
Thermal biosensors from micromachined bulk acoustic wave resonators (2011)

A micromachined Y-cut quartz resonator based thermal biosensor – configured with a reaction chamber that is physically separated but located in close proximity to the resonator for sensitive calorimetric biosensing applications is presented. The coupling of heat from the reaction chamber to the quartz resonator is achieved via radiation and conduction through ambient gas. This configuration of the sensor allows for a very robust sensing platform with no fouling of the sensor surface or degradation in its performance metrics. Frequency based and Impedance-based tracking of resonance frequency was used for chemical and enzymatic activity measurements and compared here. An impedance sensitivity of 852 Ω/°C (frequency sensitivity of 7.32 kHz/°C) was obtained for the 91 MHz.
New Geophysical Technique for Mineral Exploration and Mineral Discrimination Based on Electromagnetic Methods (2005)

The research during the first year of the project was focused on developing the foundations of a new geophysical technique for mineral exploration and mineral discrimination, based on electromagnetic (EM) methods. The proposed new technique is based on examining the spectral induced polarization effects in electromagnetic data using modern distributed acquisition systems and advanced methods of 3-D inversion. The analysis of IP phenomena is usually based on models with frequency dependent complex conductivity distribution. One of the most popular is the Cole-Cole relaxation model. In this progress report we have constructed and analyzed a different physical and mathematical model of the IP effect based on the effective-medium theory. We have developed a rigorous mathematical model of multi-phase conductive media, which can provide a quantitative tool for evaluation of the type of mineralization, using the conductivity relaxation model parameters. The parameters of the new conductivity relaxation model can be used for discrimination of the different types of rock formations, which is an important goal in mineral exploration. The solution of this problem requires development of an effective numerical method for EM forward modeling in 3-D inhomogeneous media. During the first year of the project we have developed a prototype 3-D IP modeling algorithm using the integral equation (IP) method. Our IE forward modeling code INTEM3DIP is based on the contraction IE method, which improves the convergence rate of the iterative solvers. This code can handle various types of sources and receivers to compute the effect of a complex resistivity model. We have tested the working version of the INTEM3DIP code for computer simulation of the IP data for several models including a southwest US porphyry model and a Kambalda-style nickel sulfide deposit. The numerical modeling study clearly demonstrates how the various complex resistivity models manifest differently in the observed EM data. These modeling studies lay a background for future development of the IP inversion method, directed at determining the electrical conductivity and the intrinsic chargeability distributions, as well as the other parameters of the relaxation model simultaneously. The new technology envisioned in this proposal, will be used for the discrimination of different rocks, and in this way will provide an ability to distinguish between uneconomic mineral deposits and the location of zones of economic mineralization and geothermal resources.
Driving method for gate-delay compensation of TFT/LCD (1998)

Gate delay is one of the biggest limiting factors for large-screen-size, high-resolution thin-film transistor liquid crystal display (TFT/LCD) design. To solve this problem, we have developed a new driving method which can achieve high image quality and reliability and reduce the power consumption with conventional processes, even if gate-line resistance and load capacitance are increased. The new method uses gate-pulse waveforms that separate the functions of feedthrough compensation, with pulse edge timing that greatly reduces errors due to gate delay.
Abstract PO-048: A novel chromatin remodeling domain of keratin 17 regulates transcription and promotes tumor aggression in pancreatic cancer (2021)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by two molecular subtypes, of which the basal-like subtype is associated with the worst survival and is highly resistant to first-line chemotherapy. We previously reported that keratin 17 (K17), a component of the molecular signature of the basal-like subtype, is a negative prognostic and predictive biomarker, whose overexpression results in chemoresistance and shortened patient survival. Here, we aimed to uncover the mechanistic role of K17 in driving cancer aggression and explore the therapeutic opportunities in K17-expressing PDAC. Beyond its role as a cytoskeletal protein, K17 can solubilize from the filamentous form and translocate into the nucleus, where it impacts multiple cellular properties. Previous reports suggest that nuclear K17 regulates cell-cycle progression and gene expression. However, the detailed mechanisms through which K17 modulates gene expression remains unexplored. Through domain-prediction analyses, we identified a novel chromatin-remodeling (SANT) domain in K17 that may interact with histones to regulate chromatin structure. The assay for transposase-accessible chromatin using sequencing (ATAC-seq) revealed that K17 positive cells had comparably accessible regions relative to K17 negative cells. However, the deletion of the K17 SANT domain (dSANT) decreased chromatin accessibility, suggesting that nuclear K17 impacts chromatin structure via the SANT domain. With RNA sequencing (RNA-seq) pathway enrichment analysis, we found that K17 positive cells had differential expressed genes that are associated with cell signaling, immune regulation, and metabolic pathways. More specifically, by comparing wild type K17 and dSANT K17-expressing cells, we found that the SANT domain impacts a wide variety of immune regulatory pathways, many of which affect the tumor microenvironment. We are now performing chromatin immunoprecipitation sequencing (ChIP-seq) with acetylation of lysine 27 on histone H3 protein subunit (H3K27ac), to reveal differential bindings that are impacted by K17 and the SANT domain. Importantly, mice bearing orthotopic xenografts of PDACs with K17-SANT deletion showed survival comparable to those with K17 negative tumors and had significantly longer survival than those with wild-type K17. In summary, we identified a novel chromatin remodeling domain in K17 that could be explored as a target for the development of a biomarker-based treatment for PDAC. Citation Format: Chun-Hao Pan, Robert Tseng, Simon J. Hogg, Gabriella Baraks, Cindy V. Leiton, Lucia Roa-Peña, Natalia Marchenko, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos. A novel chromatin remodeling domain of keratin 17 regulates transcription and promotes tumor aggression in pancreatic cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-048.
Production of Light Hydrocarbons from Syngas Using a Hybrid Catalyst (2017)

A hybrid catalyst consisting of a Cu-ZnO/Al2O3 methanol synthesis catalyst and a SAPO-34 molecular sieve was shown to convert syngas into a narrow mixture of short chain paraffins centered at C2–C3 with little methane and C5+ made. This product mix is expected to be an excellent cracker feedstock for the production of olefins. The hybrid catalyst system closely couples sequential reactions on each of the two independent catalysts. The function of each of the components was unraveled by performing experiments in which the reactor was loaded with discrete layers of the individual catalysts. Methanol (MeOH) synthesis over Cu-ZnO/Al2O3 is followed by methanol conversion to dimethyl ether (DME) + steam over the acidic SAPO-34 or Cu-ZnO/Al2O3 component. Simultaneously, the so generated water feeds into the water gas shift (WGS) reaction over Cu-ZnO/Al2O3, producing H2 + CO2, and the DME/MeOH undergoes methanol to olefins (MTO) conversion over SAPO-34. The olefins are subsequently hydrogenated to paraffins over the Cu-ZnO/Al2O3 and SAPO-34 catalysts using hydrogen from the feed or hydrogen produced in the WGS reaction. Comparison of fully mixed vs layered catalyst bed systems indicated that a mixed catalyst bed is preferred to give a high CO conversion and selectivity to desired paraffin products. This scheme enables high single stage conversion by consuming methanol, thereby removing the thermodynamic constraint on that reaction step. The interactions between all the reactants and catalysts in this system create a complex relationship that is probed in this paper.
Polarization-Dependent Response of Single- and Bi-Metal Antenna-Coupled Thermopiles for Infrared Detection (2015)

Antenna-coupled single- and bi-metal nanothermocouples (ACNTCs) and thermopiles for IR detection are fabricated and tested. These devices comprise a dipole antenna and a nanoscale thermocouple with lead lines. Polarization-dependent responses of antenna-coupled thermopiles with various array sizes are investigated. The polarization ratios of the various ACNTC designs are found to be significantly different. We show that the NTC lead lines act as parasitic antennas, and discuss the implications of design parameter choices.
A Single-Cell-Gap Transflective Liquid Crystal Display With Complementary Common Electrodes and Reflectors (2007)

A single-cell-gap transflective liquid crystal display with complementary common electrodes on the top substrate and reflectors on the bottom substrate is demonstrated. These slit-patterned common electrodes and reflectors generate a strong longitudinal electric field in the transmissive region (T-region) and a weak fringe field in the reflective region (R-region). Both transmissive and reflective display modes show high optical efficiency and well-matched grayscales.
NONINVASIVE CENTRAL VENOUS PRESSURE MONITORING. (2005)

Ward, Kevin; Tiba, M Hakam; Proffitt, Kate; Draucker, Jerry; Ivatury, Rao; Barbee, R Wayne; Spiess, Bruce; Arrowood, James Author Information
Polygalacturonase Isozymes and Pectin Depolymerization in Transgenic <i>rin</i> Tomato Fruit (1990)

We have previously described the construction and expression of a chimeric gene that allows developmentally regulated expression of tomato (Lycopersicon esculentum) polygalacturonase in ripening-impaired, mutant (rin) tomato fruit (JJ Giovannoni, D DellaPenna, AB Bennett, RL Fischer [1989] The Plant Cell 1: 53-63). We now show that expression of the chimeric polygalacturonase gene in rin tomato fruit resulted in the accumulation of all three polygalacturonase isozymes (PG1, PG2A, and PG2B). Polyuronide solubilization and polyuronide depolymerization both reached their maximal levels in transgenic rin fruit prior to the appearance of PG2 isozymes. These results demonstrate that PG1, PG2A, and PG2B all arise by differential processing of a single gene product and further suggest that the PG1 isozyme is sufficient to carry out both polyuronide solubilization and depolymerization in vivo.
Routing and Regenerator Planning in a Carrier’s Core Reconfigurable Optical Network (2018)

The introduction of colorless–directionless reconfigurable-optical-add-drop multiplexers (ROADMs) brings new capabilities to the physical network, including bandwidth pre-positioning, bandwidth-on-demand, optical layer mesh restoration, and wavelength defragmentation. In order to utilize these new capabilities, carriers need to pre-deploy transponders at endpoints as well as regenerators at intermediate locations when needed. Optimizing routing and regenerator planning in a carrier’s core ROADM network provides significant savings. In this paper, we describe our algorithms to minimize the total number of regenerator sites and the corresponding number of regenerators needed at each chosen site. We consider both bandwidth-on-demand wavelength services and multi-layer restoration needs to provide the upper layer with more efficient restoration. Portions of this work were presented at the Optical Fiber Communications Conference and Exhibition (OFC), March2017.
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design (2018)

Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, has emerged as an attractive target for cancer therapy. Mcl-1 upregulation is often found in many human cancers and is associated with high tumor grade, poor survival, and resistance to chemotherapy. Here, we describe a series of potent and selective tricyclic indole diazepinone Mcl-1 inhibitors that were discovered and further optimized using structure-based design. These compounds exhibit picomolar binding affinity and mechanism-based cellular efficacy, including growth inhibition and caspase induction in Mcl-1-sensitive cells. Thus, they represent useful compounds to study the implication of Mcl-1 inhibition in cancer and serve as potentially useful starting points toward the discovery of anti-Mcl-1 therapeutics.
Advances in Magnetic Current Imaging for Die-Level Fault Isolation (2006)

Abstract Recent improvements in giant magnetoresistance sensors have increased the achievable spatial resolution of magnetic current imaging on packaged devices without a significant compromise in magnetic field sensitivity. Front and backside current imaging examples show the utility of these new sensors for die-level failure analysis.
Architecture Design and Assessment with Design Matrix (2011)

Practices of developing applications based on SOA principles need to be renovated to meet new requirements for large-scale data processing and to adapt advancements in IT infrastructures in cloud computing. Resource planners will have a significant role as they bridge the development and operation phases in application development. To accomplish these tasks, this paper presents architecture design methods, which reinforce designing and assessing architecture with an applied Design Structure Matrix (DSM). This approach can embrace development of both business logics of applications and IT resources to run them in the cloud and the methods are established through consulting practices on a datacenter.