gebhart/patrepeval huggingface dataset:
Comparing Similarity Combination Methods for Schema Matching. (2010)

Abstract: A recurring manual task in data integration or ontology alignment is finding mappings between complex schemas. In order to reduce the manual effort, many matching algorithms for semi-automatically computing mappings were introduced. In the last decade it turned out that a combination of matching algorithms often improves mapping quality. Many possible combination methods can be found in literature, each promising good result quality for a specific domain of schemas. We introduce the rationale of each strategy shortly. Then we evaluate the most commonly used methods on a number of mapping tasks and try to find the most robust strategy that behaves well across all given tasks. 1
Sulfur‐Limonene Polysulfide: A Material Synthesized Entirely from Industrial By‐Products and Its Use in Removing Toxic Metals from Water and Soil (2015)

A polysulfide material was synthesized by the direct reaction of sulfur and d-limonene, by-products of the petroleum and citrus industries, respectively. The resulting material was processed into functional coatings or molded into solid devices for the removal of palladium and mercury salts from water and soil. The binding of mercury(II) to the sulfur-limonene polysulfide resulted in a color change. These properties motivate application in next-generation environmental remediation and mercury sensing.
Designing Estimator/Predictor Digital Phase-Locked Loops (1988)

Signal delays in equipment compensated automatically. New approach to design of digital phase-locked loop (DPLL) incorporates concepts from estimation theory and involves decomposition of closed-loop transfer function into estimator and predictor. Estimator provides recursive estimates of phase, frequency, and higher order derivatives of phase with respect to time, while predictor compensates for delay, called transport lag, caused by PLL equipment and by DPLL computations.
Novel pathway for bacterial metabolism of bisphenol A. Rearrangements and stilbene cleavage in bisphenol A metabolism. (1994)

Bisphenol A (BPA) is metabolized by a Gram-negative aerobic bacterium via a novel pathway involving oxidative skeletal rearrangement of the BPA. Oxidation of the aliphatic methyl group of BPA leads to coproduction of the methyl-hyroxylated 2,2-bis(4-hydroxyphenyl)-1-propanol and a skeletally rearranged triol 1,2-bis(4-hydroxyphenyl)-2-propanol. The major route of metabolism (> 80%) is through the rearrangement. The 1,2-bis(4-hydroxyphenyl)-2-propanol is dehydrated to 4,4'-dihydroxy-alpha-methylstilbene, which is rapidly cleaved by oxidation to 4-hydroxybenzaldehyde and 4-hydroxyacetophenone. 4-Hydroxybenzaldehyde is oxidized to 4-hydroxybenzoic acid. Both 4-hydroxybenzoic acid and 4-hydroxyacetophenone are mineralized. The minor product of BPA hydroxylation, 2,2-bis(4-hydroxyphenyl)-1-propanol, is further oxidized to form both 2,2-bis(4-hydroxyphenyl)propanoic acid and a skeletally rearranged tetraol, 2,3-bis(4-hydroxyphenyl)-1,2-propanediol. As is the case in the hydroxylation of BPA, the major product is skeletally rearranged. 2,3-Bis(4-hydroxyphenyl)-1,2-propanediol is slowly transformed to 4-hydroxyphenacyl alcohol.
Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. (1983)

We have developed a procedure for simultaneous flow cytometric measurement of cellular DNA content and amount of BrdUrd incorporated into cellular DNA. Propidium iodide was used as a fluorescent probe for total cellular DNA and a monoclonal antibody against BrdUrd was used as a probe for BrdUrd incorporated into DNA. Fluorescein-labeled goat anti-mouse antibody was used to fluorescently label the bound anti-BrdUrd probe. Bivariate DNA/BrdUrd distributions measured for Chinese hamster ovary cells labeled for 30 min with BrdUrd clearly show the G1-and G2M-phase cells to have low BrdUrd-linked fluorescence and the S-phase cells to have high BrdUrd-linked fluorescence. Cell cycle traverse rates were estimated for Chinese hamster ovary cells from bivariate distributions measured for samples taken periodically after pulse labeling with BrdUrd. Bivariate DNA/BrdUrd distributions were also applied in the analysis of the response of C3H murine bone marrow cells to treatment in vivo with 1-beta-D-arabinofuranosylcytosine (araC). Bivariate distributions were measured for bone marrow cells taken from mice that were pulse labeled with BrdUrd at various times after treatment with araC. The resulting DNA/BrdUrd sequences show the kinetics of recovery from araC and allow discrimination of the araC sterilized cells.
Synthesis, Characterization, and Antimicrobial Investigation of a Novel Chlorhexidine Cyclamate Complex (2020)

The synthesis, crystal structure, and antimicrobial efficacy are reported for a novel material comprising a 1:2 ratio of chlorhexidine (CHX) to N-cyclohexylsulfamate (<i>i.e.</i>, artificial sweetener known as cyclamate). The chemical structure is unambiguously identified by incorporating a combination of single-crystal X-ray diffraction (SC-XRD), electrospray ionization mass spectrometry (ESI-MS), <sup>1</sup>H nuclear magnetic resonance (NMR) spectroscopy, correlation spectroscopy (COSY), and attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR). The new material: 1) is amongst only several reported structures identified to date incorporating the vital chlorhexidine antimicrobial drug; 2) exhibits broad spectrum antimicrobial activity at concentrations less than 15 μg/mL; and 3) provides a unique delivery method for the essential active pharmaceutical ingredient (API). Furthermore, substitution of inactive gluconate with bioactive cyclamate counterion potentially provides the additional benefit of improving the taste profile of chlorhexidine.
Real-Time Wildfire Detection Using Correlation Descriptors (2011)

Publication in the conference proceedings of EUSIPCO, Barcelona, Spain, 2011
A Two‐Photon Fluorescent Probe for Lipid Raft Imaging: C‐Laurdan (2007)

The lipid-rafts hypothesis proposes that naturally occurring lipid aggregates exist in the plane of membrane that are involved in signal transduction, protein sorting, and membrane transport. To understand their roles in cell biology, a direct visualization of such domains in living cells is essential. For this purpose, 6-dodecanoyl-2-(dimethylamino)naphthalene (laurdan), a membrane probe that is sensitive to the polarity of the membrane, has often been used. We have synthesized and characterized 6-dodecanoyl-2-[N-methyl-N-(carboxymethyl)amino]naphthalene (C-laurdan), which has the advantages of greater sensitivity to the membrane polarity, a brighter two-photon fluorescence image, and reflecting the cell environment more accurately than laurdan. Lipid rafts can be visualized by two-photon microscopy by using C-laurdan as a probe. Our results show that the lipid rafts cover 38 % of the cell surface.
Thermal Energy Storage Using Solid Particles for Long-Duration Energy Storage (2020)

Abstract The rapid growth of renewable energy increases the importance of economically firming the electricity supply from variable solar photovoltaic- and wind-power generators. Energy storage will be the key to manage variability and to bridge the generation gap over time scales of hours or days for high renewable grid integration. The integration of renewable power and storage of excess electricity has several significant and positive impacts including: 1) expanding the renewable energy portion of total electricity generation, 2) improving the peak-load response, and 3) coordinating the electricity supply and demand over the grid. Long-duration energy storage can potentially complement the reduction of fossil-fuel baseload generation that otherwise would risk grid security when a large portion of grid power comes from variable renewable sources. Several energy storage methods are deployed or under development, including mechanical, chemical or electrochemical, and thermal energy storage (TES). Comparing their economic potential for different scales and applications helps identify suitable technology to support high renewable grid integration. Despite the progress of TES technologies developed and deployed with concentrating solar power (CSP) systems, TES has been undervalued for its potential role in electric energy storage. This paper introduces TES methods applicable to grid energy storage and particularly focuses on solid-particle-based TES to serve the purpose of long-duration energy storage (LDES). The objective of this paper is to present a standalone particle-based TES system for electric storage and to show the potential of TES systems for LDES applications over other energy storage methods such as batteries, compressed-air energy storage, or pumped-storage hydropower.
N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine in combination with cyclophosphamide: an active, low-toxicity regimen for metastatic hormonally unresponsive prostate cancer. (1995)

DPPE/cyclophosphamide appears to be an active regimen for metastatic prostate cancer, with the added benefit of relatively low toxicity.
An Isoform of the Coactivator AIB1 That Increases Hormone and Growth Factor Sensitivity Is Overexpressed in Breast Cancer (2001)

The AIB1 (amplified in breast cancer 1) protein is a coactivator that potentiates the transcriptional activity of nuclear hormone receptors, and its gene is amplified in a subset of human breast cancers. Here we report a splice variant of AIB1 mRNA that lacks the exon 3 sequence. We determined that the AIB-Delta3 mRNA encoded a 130-kDa protein that lacks the NH(2)-terminal basic helix-loop-helix and a portion of the PAS (Per-Arnt-Sim homology) dimerization domain. The 130-kDa protein was detected in MCF-7 breast cancer cells at levels that were 5-10% of the full-length protein, whereas in non-transformed mammary epithelium lines, the AIB-Delta3 protein was present at significantly lower levels compared with the full-length AIB1. Consistent with this finding, the abundance of AIB1-Delta3 mRNA was increased in human breast cancer specimens relative to that in normal breast tissue. To determine whether there were phenotypic changes associated with the overexpression of the AIB-Delta3 isoform, we performed functional reporter gene assays. These revealed that the ability of AIB1-Delta3 to promote transcription mediated by the estrogen or progesterone receptors was significantly greater than that of the full-length protein. Surprisingly, the AIB1-Delta3 isoform was also more effective than AIB1 in promoting transcription induced by epidermal growth factor. Overexpression of AIB1-Delta3 may thus play an important role in sensitizing breast tumor cells to hormone or growth factor stimulation.
Development of an “Interferometric Quasi-Autocollimator” (2011)

We have developed a device that uses weak-value amplification to measure angular deflections of a target mirror while remaining insensitive to all translations of the target. We present demonstrated sensitivities and discuss practical implementation.
New sulfhydryl compounds with potent antihypertensive activities. (1978)

(4R)-3-(Mercaptoacyl)-4-thiazolidinecarboxylic acids (III) were synthesized and their inhibitory activities against angiotensin-converting enzyme (ACE) were examined in vitro and in vivo. (4R)-3-[(2S)-3-Mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (4a) was the most potent orally active inhibitor of ACE among the derivatives and its activity was almost same as that of (2S)-1-[(2S)-3-mercapto-2-methylpropanoyl] proline (8).
Analysis and Optimisation of Pulse Dynamics for Magnetic Stimulation (2011)

Magnetic stimulation is a standard tool in brain research and many fields of neurology, as well as psychiatry. From a physical perspective, one key aspect of this method is the inefficiency of available setups. Whereas the spatial field properties have been studied rather intensively with coil designs, the dynamics have been neglected almost completely for a long time. Instead, the devices and their technology defined the waveform. Here, an analysis of the waveform space is performed. Based on these data, an appropriate optimisation approach is outlined which makes use of a modern nonlinear axon description of a mammalian motor nerve. The approach is based on a hybrid global-local method; different coordinate systems for describing the continuous waveforms in a limited parameter space are defined for sufficient stability. The results of the numeric setup suggest that there is plenty of room for waveforms with higher efficiency than the traditional shapes. One class of such pulses is analysed further. Although the voltage profile of these waveforms is almost rectangular, the current shape presents distinct characteristics, such as a first phase which precedes the main pulse and decreases the losses. The single representatives, which differ in their maximum voltage shape, are linked by a nonlinear transformation. The main phase, however, seems to scale in time only.
Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young. (2000)

Mutations in the transcription factors hepatocyte nuclear factor (HNF)-4alpha and -1alpha, insulin promoter factor-1, and HNF-1beta are the causes of four forms of maturity-onset diabetes of the young (MODY1 and 3-5, respectively). The winged-helix transcription factor HNF-3beta has been implicated in the regulation of expression of each of these MODY genes, suggesting that mutations in the HNF-3beta gene (HNF3B) may also cause MODY. We have tested this hypothesis by screening a panel of 57 unrelated Japanese subjects with a clinical diagnosis of MODY for mutations in HNF3B. This analysis revealed four frequent polymorphisms that were not associated with MODY, including one in the promoter region (-213A/G), two silent mutations in the codons for Ala 97 (291C/T) and Gly 279 (837A/G), and one in the 3'-untranslated region (1424C/T). Two rare substitutions in the 5'-untranslated region, -156C/T and -67A/C, were found in a heterozygous state in two subjects, and two subjects were heterozygous for putative missense mutations, S109N (326G > A) and A328V (983C>T). The two missense mutations were not found in 106 normal chromosomes from nondiabetic subjects. It was not possible to test for co-segregation of these mutations with diabetes and thus, it is unclear whether or not these mutations can cause MODY. The results of our study suggest that mutations in HNF3B are not a common cause of MODY in Japanese subjects.
Suppression of Carbon Deposition in the Iron‐Catalyzed Production of Lower Olefins from Synthesis Gas (2012)

Pressure leverage: A tapered-element oscillating microbalance was used to evaluate carbon deposition on a highly selective and active supported iron catalyst for the production of lower olefins. With increasing pressure, the H(2)/CO ratio had a profound effect on the carbon deposition rate and accordingly, conditions leading to minimal carbon deposition, low methane selectivity, and high olefin selectivity were identified.
Investigation of impurities in type-II InAs/GaSb superlattices via capacitance-voltage measurement (2013)

Capacitance-voltage measurement was utilized to characterize impurities in the non-intentionally doped region of Type-II InAs/GaSb superlattice p-i-n photodiodes. Ionized carrier concentration versus temperature dependence revealed the presence of a kind of defects with activation energy below 6 meV and a total concentration of low 1015 cm−3. Correlation between defect characteristics and superlattice designs was studied. The defects exhibited a p-type behavior with decreasing activation energy as the InAs thickness increased from 7 to 11 monolayers, while maintaining the GaSb thickness of 7 monolayers. With 13 monolayers of InAs, the superlattice became n-type and the activation energy deviated from the p-type trend.
An automatic focusing and stigmating system for the SEM (1979)

A digital minicomputer has been interfaced with a scanning electron microscope, and programmed to control the excitations of the objective lens and the stigmator of the microscope. The electron beam is scanned by a digital scan generator and the digitised video signal is used for computations. To focus the microscope, a parameter related to the 'sharpness' of the image is maximised, and to set the stigmator, the directional information in the above- and below-focus images is used.
Ferroelectrics in Microwave Devices, Circuits and Systems: Physics, Modeling, Fabrication and Measurements (2009)

Today’s wireless communications and information systems are heavily based on microwave technology, as are an increasing number of other industry sectors. Extensive research has been carried out into the development of new technologies to meet the increasingly complex requirements of such systems. Among these new technologies agile (tuneable, reconfigurable, and adaptable) microwave components based on ferroelectric materials, have great potential and are already gaining ground.Ferroelectrics in Microwave Devices, Circuits and Systems is an introduction to the field. It explores the emergence of new functionalities and components with enhanced performance that can meet the agility and cost requirements of modern microwave-based systems. The book provides the reader with practical knowledge in a range of areas, including:• physics,• fabrication technology,• methods of design,• modeling, and• measurement of ferroelectric components and devices.Ferroelectrics in Microwave Devices, Circuits and Systems is a useful research tool for both graduate and undergraduate students, as well as designers of microwave devices, circuits, and systems.The Engineering Materials and Processes series focuses on all forms of materials and the processes used to synthesise and formulate them as they relate to the various engineering disciplines. The series deals with a diverse range of materials: ceramics; metals (ferrous and non-ferrous); semiconductors; composites, polymers, biomimetics etc. Each monograph in the series is written by a specialist and demonstrates how enhancements in materials and the processes associated with them can improve performance in the field of engineering in which they are used
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase (2022)

Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of BTK has been shown to be effective in treating hematological malignancies and is hypothesized to provide an effective strategy for the treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. We report the discovery and preclinical properties of JNJ-64264681 (<b>13</b>), a covalent, irreversible BTK inhibitor with potent whole blood activity and exceptional kinome selectivity. JNJ-64264681 demonstrated excellent oral efficacy in both cancer and autoimmune models with sustained in vivo target coverage amenable to once daily dosing and has advanced into human clinical studies to investigate safety and pharmacokinetics.
Capacity of closed-access femtocell networks with dynamic spectrum reuse (2010)

Access configuration of femtocell networks carries critical importance due to the resulting interference scenarios. Especially in closed-access femtocell networks, there might be significant interference between the femtocell and the macrocell users. In this paper, we evaluate the capacity of closed access femtocell networks employing various dynamic spectrum reuse techniques. When there is a macrocell user in the vicinity of a femtocell, the femtocell may dynamically decide not to reuse the spectrum of the macrocell user to avoid interference. We discuss and evaluate the following three decision criteria for this purpose: maximum sum capacity, minimum macrocell loss, and minimum effective interference. Computer simulations in realistic settings are provided to demonstrate possible gains with the proposed methods.
<title>Optimally curved electrodes for a rotary microactuator</title> (2000)

The rotary electro-static micro actuators integrating optimally curved electrodes are proposed to enhance the actuating force-generation capability. The results show that the actuating force-generation capability. The results show that the actuating force generated by the prosed design is more than 5 times greater than the conventional shape for the application of hard disk drive device. Also, the results indicate that, as the smaller gap size is allowable, the force generation capability will be dramatically enhanced. In this design the uniformity in the capacitive gap size is the additional feature to be in favor of fabrication of a micro-actuator.
High speed and high gain-bandwidth-product resonant-cavity InGaAs/InAlAs avalanche photodiodes (2003)

An AlInAs/InGaAs resonant-cavity SACM avalanche photodiode with high external quantum efficiency (/spl sim/70%),low noise (k<0.3), a unity-gain bandwidth of 24 GHz, and a gain-bandwidth-product of 290 GHz is reported.
Portable Trench Barrier for Protecting Edges of Tomato Fields from Colorado Potato Beetle (Coleoptera: Chrysomelidae) (2001)

Experiments were conducted to test a portable trench barrier composed of an extruded, UV-retarded, PVC plastic trough, designed to allow Colorado potato beetles, Leptinotarsa decemlineata (Say), to enter and become trapped and killed inside. Tests demonstrated that the portable plastic trenches were effective as barriers to Colorado potato beetles as they walked into tomato, Lycopersicon esculentum Mill., fields from overwintering sites in the spring. In field tests, plots that were protected by portable trench barriers had significantly fewer beetles per tomato plant, and lower levels of defoliation. Tomato yields in plots that were protected by portable trench barriers were similar to yields in plots that were protected by insecticide sprays, and significantly higher than plots where beetles were not controlled.
Biological evaluation of substance P antagonists (1984)

Five undeca- and six C-terminal heptapeptide substance P (SP) analogues were tested for their capacity to block the contractile effect of SP on the guinea-pig isolated taenia coli. They had one feature in common, namely substitutions in positions 7 and 9 in the SP molecule. In the majority of analogues D-tryptophan was used for these substitutions. All analogues tested were found to be competitive antagonists to exogenous SP and to be capable of blocking the electrically induced non-cholinergic, non-adrenergic neuronal contraction of the taenia. Of the undecapeptides, (D-Arg1, D-Pro2, D-Trp7,9, Leu11) SP and (D-Arg1, D-Trp7,9, Leu11) SP (Spantide) had the highest pA2 value, 7.1-7.2, and the lowest IC50 value, 10(-6) M. The pA2 values of the heptapeptides were generally lower. Three of the most potent antagonists were tested for specificity and found to block the smooth muscle contraction induced by SP, physalaemin, eledoisin and bombesin but not that induced by bradykinin, carbachol, 5-hydroxytryptamine, histamine, prostaglandins and vasopressin. The SP antagonists were also tested for spasmogenic effect on the taenia and for their capacity to release histamine from rat isolated peritoneal mast cells. The spasmogenic activity displayed by most of the SP antagonists tested is likely to be related to their ability to release histamine since the contractile response was reduced by mepyramine, a histamine H1-receptor antagonist. (D-Arg1, D-Trp7,9, Leu11) SP was notable for combining a high antagonistic potency with a weak spasmogenic effect (and poor histamine releasing effect).