gebhart/patrepeval huggingface dataset:
Performance analysis of MVDR algorithm in the presence of amplitude and phase errors (2002)

The sensitivity of a spectrum estimation approach, the minimum variance distortionless response spectrum estimator, to random perturbations in the amplitude and phase of array sensors and channels is studied. Analytical expressions for the mean and variance of the spatial spectrum are derived. The effects of the amplitude error on the spectrum is greater relatively than that of the phase error. Theoretical results are validated by computer simulation. These expressions are then used to study the characteristics of the estimator.
Double-Stranded RNA Induces the Synthesis of Specific Chemokines by Bronchial Epithelial Cells (2003)

Virus-induced secretion of proinflammatory chemokines (e.g., regulated on activation, normal T cells expressed and secreted [RANTES], interleukin [IL]-8) by airway epithelial cells helps to initiate antiviral responses and airway inflammation by enhancing inflammatory cell recruitment. To define mechanisms for virus-induced chemokine secretion, monolayers of nontransformed bronchial epithelial cells were transfected or incubated with polydeoxyinosinic-deoxycytidylic acid (synthetic double-stranded [ds] RNA), rhinovirus dsRNA, or single-stranded RNA (ssRNA), and the secretion of selected chemokines was determined. Transfection or incubation with dsRNA, but not ssRNA, significantly enhanced secretion of RANTES and IL-8, but not eotaxin or macrophage inflammatory protein-1alpha. Mechanistically, dsRNA induced and activated dsRNA-dependent protein kinase (PKR), and activated nuclear factor-kappaB and p38 mitogen-activated protein kinase. Furthermore, the PKR inhibitor 2-aminopurine significantly blocked dsRNA-induced RANTES and IL-8 secretion, whereas the p38 mitogen-activated protein kinase inhibitor SB203580 suppressed dsRNA-induced IL-8, but not RANTES. These findings indicate that dsRNA selectively induce the secretion of chemokines such as IL-8 and RANTES, and implicate dsRNA-sensitive signaling proteins in this process. Moreover, these data suggest that this may be an important mechanism for the selective secretion of chemokines by viruses (e.g., rhinovirus, respiratory syncytial virus, influenza) that synthesize dsRNA during replication.
El prácticum de implicación: un espacio de conexión entre la Universidad y la realidad profesional. Una propuesta concreta (2001)

En todos los planes de estudio siempre se ha manifestado una preocupacion por establecer relaciones entre la educacion y el mundo del trabajo, intentando facilitar a los alumnos un conocimiento experiencial, tratando de equipar a las personas con las habilidades ocupacionales concretas requeridas para triunfar en profesiones especificas, es decir, la Universidad pretende cumplir la funcion social que, en la actualidad se le ha encomendado: preparar profesionales que puedan insertarse en el mundo laboral.
Accurate methods for estimating transmission line parameters using synchronized and unsynchronized data (2017)

There is an increasing deployment of renewable energy sources in electrical power system. Designing efficient control of power system is essential in maintaining safety and reliability of the power system. Modeling of power systems plays a key role in power system analysis and designing protection and control algorithms and diverse smart grid applications. Among various power system model parameters, line parameters are key parameters, and accurate value of line parameters will ensure the reliability and accuracy of the algorithms and applications that rely on line parameters. This paper is devoted to estimating transmission line positive-sequence parameters from unsynchronized measurements of voltage and current phasors that are obtained at both terminals of the line. The series impedance and shunt admittance line parameters can be linearly estimated using the algorithm developed in this paper. The algorithm is developed based on the distributed parameter line model, and the line is assumed to be transposed. The approach developed in this paper is considered as a linear method, and the linear least square method is used to estimate the positive-sequence line parameters. The method is also applicable to synchronized measurements obtained by Phasor Measurement Unit and is able to deal with potential synchronization errors by explicitly modeling the synchronization angle. Sample results are reported to demonstrate the effectiveness of the proposed method.
Back‐channel‐etched thin‐film transistor using <i>c</i>‐axis‐aligned crystal In–Ga–Zn oxide (2014)

Abstract Our crystalline In–Ga–Zn oxide (IGZO) thin film has a c ‐axis‐aligned crystal (CAAC) structure and maintains crystallinity even on an amorphous base layer. Although the crystal has c ‐axis alignment, its a ‐axis and b ‐axis have random arrangement; moreover, a clear grain boundary is not observed. We fabricated a back‐channel‐etched thin‐film transistor (TFT) using the CAAC‐IGZO film. Using the CAAC‐IGZO film, more stable TFT characteristics, even with a short channel length, can be obtained, and the instability of the back channel, which is one of the biggest problems of IGZO TFTs, is solved. As a result, we improved the process of manufacturing back‐channel‐etched TFTs.
Ultra-Wideband Digital-to-Analog Conversion Technologies for Tbit/s channel transmission (2017)

We review technologies to extend the analog bandwidth of electronic digital-to-analog converters (DACs) using an analog multiplexer for advanced optical transmission systems. Arbitrary signals with electronic bandwidth of up to ~60 GHz can be generated with two CMOS DACs.
Surface expression of gp165/95, the complement receptor CR3, as a marker of disease activity in systemic lupus erythematosus (1988)

Complement-derived peptides capable of activating neutrophils appear in plasma during flares of systemic lupus erythematosus (SLE). One possible consequence of such activation is an increased expression of the surface adhesion promoting heterodimer gp165/95 (the complement receptor CR3). The quantity of gp165/95 was measured by indirect immunofluorescence using a monoclonal antibody of the CD11b group. Mol, directed to the alpha chain. Eighty-three percent of 26 patients with SLE expressed gp165/95 on their neutrophil surface to a greater extent than normals. The highest levels of surface gp165/95 were found in patients with the most severe disease, who also had the highest levels of the circulating anaphylatoxin C3a (mean = 560 ng/ml versus 147 ng/ml in controls). There was a negative correlation between expression of gp165/95 and absolute neutrophil count. Five individuals followed serially demonstrated an increase in surface gp165/95 during disease flares which returned to normal with clinical improvement. These data support the hypothesis that the neutrophils of patients with active SLE recruit increased numbers of gp165/95 molecules to their surface in respose to complement activation; these activated neutrophils bearing increased numbers of adhesion promoting gp165/95 may contribute to endothelial injury in SLE.
Thermal Hydraulic Analysis Using GIS on Application of HTR to Thermal Recovery of Heavy Oil Reservoirs (2012)

At present, large water demand and carbon dioxide (CO 2 ) emissions have emerged as challenges of steam injection for oil thermal recovery. This paper proposed a strategy of superheated steam injection by the high-temperature gas-cooled reactor (HTR) for thermal recovery of heavy oil, which has less demand of water and emission of CO 2 . The paper outlines the problems of conventional steam injection and addresses the advantages of superheated steam injection by HTR from the aspects of technology, economy, and environment. A Geographic Information System (GIS) embedded with a thermal hydraulic analysis function is designed and developed to analyze the strategy, which can make the analysis work more practical and credible. Thermal hydraulic analysis using this GIS is carried out by applying this strategy to a reference heavy oil field. Two kinds of injection are considered and compared: wet steam injection by conventional boilers and superheated steam injection by HTR. The heat loss, pressure drop, and possible phase transformation are calculated and analyzed when the steam flows through the pipeline and well tube and is finally injected into the oil reservoir. The result shows that the superheated steam injection from HTR is applicable and promising for thermal recovery of heavy oil reservoirs.
Surgical Versus Nonoperative Treatment for Lumbar Disc Herniation (2013)

In Brief Study Design. Concurrent prospective randomized and observational cohort studies. Objective. To assess the 8-year outcomes of surgery versus nonoperative care. Summary of Background Data. Although randomized trials have demonstrated small short-term differences in favor of surgery, long-term outcomes comparing surgical with nonoperative treatment remain controversial. Methods. Surgical candidates with imaging-confirmed lumbar intervertebral disc herniation meeting Spine Patient Outcomes Research Trial eligibility criteria enrolled into prospective randomized (501 participants) and observational cohorts (743 participants) at 13 spine clinics in 11 US states. Interventions were standard open discectomy versus usual nonoperative care. Main outcome measures were changes from baseline in the SF-36 Bodily Pain and Physical Function scales and the modified Oswestry Disability Index-AAOS/Modems version assessed at 6 weeks, 3 months, and 6 months, and annually thereafter. Results. Advantages were seen for surgery in intent-to-treat analyses for the randomized cohort for all primary and secondary outcomes other than work status; however, with extensive nonadherence to treatment assignment (49% patients assigned to nonoperative therapy receiving surgery versus 60% of patients assigned to surgery) these observed effects were relatively small and not statistically significant for primary outcomes (bodily pain, physical function, Oswestry Disability Index). Importantly, the overall comparison of secondary outcomes was significantly greater with surgery in the intent-to-treat analysis (sciatica bothersomeness [P > 0.005], satisfaction with symptoms [P > 0.013], and self-rated improvement [P > 0.013]) in long-term follow-up. An as-treated analysis showed significant surgical treatment effects for primary outcome measures (mean change, surgery vs. nonoperative care; treatment effect; 95% confidence interval): bodily pain (45.3 vs. 34.4; 10.9; 7.7 to 14); PF (42.2 vs. 31.5; 10.6; 7.7 to 13.5); and Oswestry Disability Index (−36.2 vs. −24.8; −11.3; −13.6 to −9.1). Conclusion. Carefully selected patients who underwent surgery for a lumbar disc herniation achieved greater improvement than nonoperatively treated patients; there was little to no degradation of outcomes in either group (operative and nonoperative) from 4 to 8 years. Level of Evidence: 2 Eight-year results of the Spine Patient Outcomes Research Trial (SPORT) are detailed, including discussion of crossover and comparisons to similar trials. At 8 years, patients who had surgery for intervertebral disc herniation maintained greater improvement than those who remained nonoperative.
Training-Based MIMO Systems—Part I: Performance Comparison (2007)

In this paper, we make a performance comparison between two different training-based schemes for multiple-input multiple-output (MIMO) channel estimation. The two schemes are the conventional time-multiplexed pilot (CP) scheme and the more recently suggested superimposed pilot (SIP) scheme. Unlike previous comparisons found in the literature, which are mostly based on estimation error performances, the performance comparison in this paper is made by deriving and comparing the maximum data rate (or rather a tight lower bound on the maximum mutual information) achieved by each scheme. By using the maximum mutual information criterion, for each training scheme, we can optimally allocate the time and power spent on transmission of training and data sequences. Once the system parameters (time and power) are tuned to give optimal performance, we can compare their respective maximum data rate. The theory is applied to a blockwise flat-fading MIMO channel, and it is found that in certain scenarios (such as many receive antennas and/or short channel coherence times), it is beneficial to use the SIP. In other scenarios, the SIP scheme suffers from a higher estimation error, and its gain over the CP scheme is often lost.
Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity (2012)

4-anilino quinazolines have been identified as inhibitors of HCV replication. The target of this class of compounds was proposed to be the viral protein NS5A, although unequivocal proof has never been presented. A 4-anilino quinazoline moiety is often found in kinase inhibitors, leading us to formulate the hypothesis that the anti-HCV activity displayed by these compounds might be due to inhibition of a cellular kinase. Type III phosphatidylinositol 4-kinase α (PI4KIIIα) has recently been identified as a host factor for HCV replication. We therefore evaluated AL-9, a compound prototypical of the 4-anilino quinazoline class, on selected phosphatidylinositol kinases. AL-9 inhibited purified PI4KIIIα and, to a lesser extent, PI4KIIIβ. In Huh7.5 cells, PI4KIIIα is responsible for the phosphatidylinositol-4 phosphate (PI4P) pool present in the plasma membrane. Accordingly, we observed a gradual decrease of PI4P in the plasma membrane upon incubation with AL-9, indicating that this agent inhibits PI4KIIIα also in living cells. Conversely, AL-9 did not affect the level of PI4P in the Golgi membrane, suggesting that the PI4KIIIβ isoform was not significantly inhibited under our experimental conditions. Incubation of cells expressing HCV proteins with AL-9 induced abnormally large clusters of NS5A, a phenomenon previously observed upon silencing PI4KIIIα by RNA interference. In light of our findings, we propose that the antiviral effect of 4-anilino quinazoline compounds is mediated by the inhibition of PI4KIIIα and the consequent depletion of PI4P required for the HCV membranous web. In addition, we noted that HCV has a profound effect on cellular PI4P distribution, causing significant enrichment of PI4P in the HCV-membranous web and a concomitant depletion of PI4P in the plasma membrane. This observation implies that HCV--by recruiting PI4KIIIα in the RNA replication complex--hijacks PI4P metabolism, ultimately resulting in a markedly altered subcellular distribution of the PI4KIIIα product.
The Jak-STAT Pathway Stimulated by Interleukin 6 (2004)

Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by a variety of growth-regulating signals as well as diverse cytokines that use gp130 signaling receptors. STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune regulatory and homeostatic functions. The animation shows activation of STAT3 in response to interleukin 6 (IL6), a cytokine involved in triggering inflammation.
Binding specificities and affinities of <i>egf</i> domains for ErbB receptors (1999)

ErbB receptor activation is a complex process and is dependent upon the type and number of receptors expressed on a given cell. Previous studies with defined combinations of ErbB receptors expressed in mammalian cells have helped elucidate specific biological responses for many of the recognized gene products that serve as ligands for these receptors. However, no study has examined the binding of these ligands in a defined experimental system. To address this issue, the relative binding affinities of the egf domains of eleven ErbB ligands were measured on six ErbB receptor combinations using a soluble receptor-ligand binding format. The ErbB2/4 heterodimer was shown to bind all ligands tested with moderate to very high affinity. In contrast, ErbB3 showed much more restrictive ligand binding specificity and measurable binding was observed only with heregulin, neuregulin2beta, epiregulin and the synthetic heregulin/egf chimera, biregulin. These studies also revealed that ErbB2 preferentially enhances ligand binding to ErbB3 or ErbB4 and to a lesser degree to ErbB1.
Aeronautical channel modeling (2002)

A class of aeronautical wide-band channel models is proposed, featuring parking and taxi environments, takeoff and landing situations, and en-route scenarios for ground-air and air-air links. Typical and worst case parameter sets are suggested, based on published measurement results and empirical data. The models are suitable for channel emulators that can be easily implemented on digital computers or in hardware and thus are useful for the validation of digital aeronautical links. A time-domain and frequency-domain implementation of such a channel emulator are derived, and results for a typical multicarrier system are presented. It is shown that the scenarios have distinguishable performance results depending on the underlying maximum ranges and shapes of the Doppler and delay spectra and the presence of a line-of-sight path. Finally, the degrading effects of intersymbol interference and intersubcarrier interference on the multicarrier signal are explained.
Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA (2013)

In spite of the many developments in synthetic oligonucleotide (ON) chemistry and design, invasion into double-stranded DNA (DSI) under physiological salt and pH conditions remains a challenge. In this work, we provide a new ON tool based on locked nucleic acids (LNAs), designed for strand invasion into duplex DNA (DSI). We thus report on the development of a clamp type of LNA ON-bisLNA-with capacity to bind and invade into supercoiled double-stranded DNA. The bisLNA links a triplex-forming, Hoogsteen-binding, targeting arm with a strand-invading Watson-Crick binding arm. Optimization was carried out by varying the number and location of LNA nucleotides and the length of the triplex-forming versus strand-invading arms. Single-strand regions in target duplex DNA were mapped using chemical probing. By combining design and increase in LNA content, it was possible to achieve a 100-fold increase in potency with 30% DSI at 450 nM using a bisLNA to plasmid ratio of only 21:1. Although this first conceptual report does not address the utility of bisLNA for the targeting of DNA in a chromosomal context, it shows bisLNA as a promising candidate for interfering also with cellular genes.
Identification of genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses (2020)

The virulence of influenza viruses is a complex multigenic trait. Previous studies about the virulence determinants of influenza viruses mainly focused on amino acid sites, ignoring the influence of nucleotide mutations. In this study, we collected >200 viral strains from 21 subtypes of influenza A viruses with virulence in mammals and obtained over 100 mammalian virulence-related nucleotide sites across the genome by computational analysis. Fifty of these nucleotide sites only experienced synonymous mutations. Experiments showed that synonymous mutations in three high-scoring nucleotide sites, i.e., PB1–2031, PB1–633, and PB1–720, enhanced the pathogenicity of the influenza A(H1N1) viruses in mice. Besides, machine-learning models with accepted accuracy for predicting mammalian virulence of influenza A viruses were built. Overall, this study highlighted the importance of nucleotide mutations, especially synonymous mutations in viral virulence, and provided rapid methods for evaluating the virulence of influenza A viruses. It could be helpful for early warning of newly emerging influenza A viruses.
A Monitorable Peer-to-Peer File Sharing Mechanism (2019)

With the rise of blockchain technology, peer-to-peer network system has once again caught people's attention. Peer-to-peer (P2P) is currently being implemented on various kind of decentralized systems such as InterPlanetary File System (IPFS). However, P2P file sharing network systems is not without its flaws. Data stored in the other nodes cannot be deleted by the owner and can only be deleted by other nodes themselves. Ensuring that personal data can be completely removed is an important issue to comply with the European Union's General Data Protection Regulation (GDPR) criteria. To improve P2Ps privacy and security, we propose a monitorable peer-to-peer file sharing mechanism that synchronizes with other nodes to perform file deletion and to generate the File Authentication Code (FAC) of each IPFS nodes in order to make sure the system synchronized correctly. The proposed mechanism can integrate with a consortium Blockchain to comply with GDPR.
Ionic Conductivity of Polyacid-Poly(Vinyl Alcohol)-Metal Ion Complex Membranes (1987)

Abstract Polymeric complex membranes with high ionic conductivity have been prepared from polyacid, poly(vinyl alcohol), and metal ions. It was found that the ionic conductivity of bipolymer-metal ion complexes is higher than that of single polymer-metal ion complexes. Their ionic conductivity is discussed in relation to the acid strength of the polyacid, the size of the metal ions, the dielectric constants of the additives, and the temperature.
Tunneling versus Hopping in Mixed-Valence Oligo-<i>p</i>-phenylenevinylene Polychlorinated Bis(triphenylmethyl) Radical Anions (2011)

Radical anions 1(-•)-5(-•), showing different lengths and incorporating up to five p-phenylenevinylene (PPV) bridges between two polychlorinated triphenylmethyl units, have been prepared by chemical or electrochemical reductions from the corresponding diradicals 1-5 which were prepared using Wittig-Horner-type chemistry. Such radical anions enabled us to study, by means of UV-vis-NIR and variable-temperature electron spin resonance spectroscopies, the long-range intramolecular electron transfer (IET) phenomena in their ground states, probing the influence of increasing the lengths of the bridges without the need of using an external bias to promote IET. The temperature dependence of the IET rate constants of mixed-valence species 1(-•)-5(-•) revealed the presence of two different regimes at low and high temperatures in which the mechanisms of electron tunneling via superexchange and thermally activated hopping are competing. Both mechanisms occur to different extents, depending on the sizes of the radical anions, since the lengths of the oligo-PPV bridges notably influence the tunneling efficiency and the activation energy barriers of the hopping processes, the barriers diminishing when the lengths are increased. The nature of solvents also modifies the IET rates by means of the interactions between the oligo-PPV bridges and the solvents. Finally, in the shortest compounds 1(-•) and 2(-•), the IET induced optically through the superexchange mechanism can also be observed by the exhibited intervalence bands, whose intensities decrease with the length of the PPV bridge.