gebhart/patrepeval huggingface dataset:
Phase II trial of the anti-prostate specific membrane antigen (PSMA) monoclonal antibody (mAb) J591 plus low-dose interleukin-2 (IL-2) in patients (pts) with recurrent prostate cancer (PC) (2007)

15558 Background: The de-immunized mAb J591 recognizes the extracellular domain of PSMA and was engineered to induce antibody-dependent cellular cytotoxicity (ADCC). Low-dose IL-2 results in the clonal expansion of NK cells and may enhance ADCC. We conducted a phase 2 trial to determine the efficacy and toxicity of mAb J591 plus low-dose subcutaneous (SC) IL-2 in pts with recurrent PC. Methods: 17 pts with recurrent PC (2 groups: 11 with PSA relapse only; and 6 with progressive castrate metastatic disease) received continuous low-dose SC IL-2 (1.2 x 10 6 IU/m2/day) daily for 8 weeks with mAb J591 (25 mg/m 2 IV) weekly on weeks 4, 5 and 6 (1 cycle). Pts could receive a maximum of 3 cycles. Results: 16 evaluable pts received up to 3 cycles of therapy (16 pts, one cycle, 9 two cycles and 2 three cycles). Toxicity was mild and limited to fatigue and injection site reactions. At the end of cycle 1, PSA was stable (-50%<change in PSA<25%) in 9 of 16 patients, with PSA declines up to 34%. No PSA decline >50% was observed. A post-hoc analysis of PSA kinetics showed 5 patients had a reduction in their PSA slope of =25%; 8 of the remaining 11 patients demonstrated PSA stabilization (- 25%<change in PSA slope<25%). PSA response was most commonly observed during weeks 4–6 of the cycle correlating with mAb administration. Flow cytometric analysis of peripheral blood mononuclear cells revealed an average increase in absolute NK cell count of 107% at week 4 and 117% at the end of cycle 1. Conclusions: The combination of mAb J591 with low-dose IL-2 was well tolerated and inhibited PSA kinetics in some patients, however no responses were seen. Repetitive dosed mAb J591 is a viable strategy for use in combination with immune modulatory or other therapies in recurrent prostate cancer. No significant financial relationships to disclose.
Detection of inflamed atherosclerotic lesions with diadenosine-5′,5‴- <i>P</i> <sup>1</sup> , <i>P</i> <sup>4</sup> -tetraphosphate (Ap <sub>4</sub> A) and positron-emission tomography (2006)

Diadenosine-5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) and its analog P(2),P(3)-monochloromethylene diadenosine-5',5'''-P(1),P(4)-tetraphosphate (AppCHClppA) are competitive inhibitors of adenosine diphosphate-induced platelet aggregation, which plays a central role in arterial thrombosis and plaque formation. In this study, we evaluate the imaging capabilities of positron-emission tomography (PET) with P(2),P(3)-[(18)F]monofluoromethylene diadenosine-5',5'''-P(1),P(4)-tetraphosphate ([(18)F]AppCHFppA) to detect atherosclerotic lesions in male New Zealand White rabbits. Three to six months after balloon injury to the aorta, the rabbits were injected with [(18)F]AppCHFppA, and microPET imaging showed rapid accumulation of this radiopharmaceutical in the atherosclerotic abdominal aorta, with lesions clearly visible 30 min after injection. Computed tomographic images were coregistered with PET images to improve delineation of aortoiliac tracer activity. Plaque macrophage density, quantified by immunostaining with RAM11 against rabbit macrophages, correlated with PET measurements of [(18)F]AppCHFppA uptake (r = 0.87, P < 0.0001), whereas smooth-muscle cell density, quantified by immunostaining with 1A4 against smooth muscle actin, did not. Biodistribution studies of [(18)F]AppCHFppA in normal rats indicated typical adenosine dinucleotide behavior with insignificant myocardial uptake and fast kidney clearance. The accumulation of [(18)F]AppCHFppA in macrophage-rich atherosclerotic plaques can be quantified noninvasively with PET. Hence, [(18)F]AppCHFppA holds promise for the noninvasive characterization of vascular inflammation.
Rule Restriction in Event Descriptive Unit Identify (2010)

In the research of events description in the identification unit based on rules, formulation of rules becomes a core issue. This thesis selects 3751 information corpus of TCT corpus for the study, summarizes 9 predicate identification rules and 14 phrases merger rules, and quantify the importance of the rules by the contribution. Furthermore, the relationship between the binding rules is studied by a large number of experiments. Experimental results show that the binding between the different rules has different influence on event description unit. The paper is supported by Science and Technology Department of Shanxi Province international cooperation and exchange project ”China-Japan Cooperation Research on Chinese Intelligent Interactive Question and Answer System Based on Web ”(Grant No.2009g18).
Barbed sutures: Rationale and technique (2006)

The author provides a comprehensive overview of barbed suture technology, explaining the hypothesized underlying cellular mechanism. He then describes the procedure, including patient selection, materials, and technique.
β-Glycosidase inhibitors mimicking the pyranoside boat conformation (2000)

Polyhydroxylated isoquinuclidines mimicking the boat conformation of pyranosides are strong and selective inhibitors of a retaining β-mannosidase.
Automated suppression of howling noise using sinusoidal model based analysis/synthesis (2014)

Automated suppression of howling noise in public address systems is of utmost importance as howling noise is very annoying to the speaker and audience. It adversely affects speech intelligibility. Howling is built up by a positive feedback loop set up between microphone, amplifier, and the speaker system. An automated method for detection and suppression of howling noise is proposed using sinusoidal model based analysis/synthesis. The method automatically adapts to the properties of howling noise and has the advantage of suppressing the noise, without degrading speech intelligibility. The system has been tested for satisfactory operation using a computer-based setup.
Autism‐like behavioral phenotypes in BTBR T+tf/J mice (2007)

Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse models with face validity to the core symptoms offer an experimental approach to test hypotheses about the causes of autism and translational tools to evaluate potential treatments. We discovered that the inbred mouse strain BTBR T+tf/J (BTBR) incorporates multiple behavioral phenotypes relevant to all three diagnostic symptoms of autism. BTBR displayed selectively reduced social approach, low reciprocal social interactions and impaired juvenile play, as compared with C57BL/6J (B6) controls. Impaired social transmission of food preference in BTBR suggests communication deficits. Repetitive behaviors appeared as high levels of self-grooming by juvenile and adult BTBR mice. Comprehensive analyses of procedural abilities confirmed that social recognition and olfactory abilities were normal in BTBR, with no evidence for high anxiety-like traits or motor impairments, supporting an interpretation of highly specific social deficits. Database comparisons between BTBR and B6 on 124 putative autism candidate genes showed several interesting single nucleotide polymorphisms (SNPs) in the BTBR genetic background, including a nonsynonymous coding region polymorphism in Kmo. The Kmo gene encodes kynurenine 3-hydroxylase, an enzyme-regulating metabolism of kynurenic acid, a glutamate antagonist with neuroprotective actions. Sequencing confirmed this coding SNP in Kmo, supporting further investigation into the contribution of this polymorphism to autism-like behavioral phenotypes. Robust and selective social deficits, repetitive self-grooming, genetic stability and commercial availability of the BTBR inbred strain encourage its use as a research tool to search for background genes relevant to the etiology of autism, and to explore therapeutics to treat the core symptoms.
Recent advances in variable speed electrical generator systems for large wind turbines (1983)

Major variable speed electrical generator system design objectives have been verified through large-scale experiment. Full exploitation of variable speed generator benefits can revolutionize large wind turbine design. The greatest advantages come not only from the improved aerodynamic efficiency of keeping tip speed proportional to wind speed, but from dramatic reduction in drive train resonances, elimination of dissipative damping losses, easy motorized turbine start, and isolation of turbine dynamics from the electrical network. Experimental verification proceeded by two steps: first, actual control hardware and software were verified with a hybrid simulation of a full wind turbine system; then the controls were combined with power thyristor bridges configured as a cycloconverter and motor-generator test train to implement a variable speed generator and a simulated wind-turbine/drive train. Although the existing equipment presented several constraints on testing latitude, major features demonstrated include: (1) variable frequency motoring to 50% speed for quick, efficient turbine start-up; (2) synchronization below, at, and above synchronous speeds, both steady state and transient; (3) net power output up to 120 kW with stable response to 50 kW step changes in demand within one second and similarly responsive control of VARs; (4) steady power and VAR output throughout speed transients frommore » ten percent below to ten percent above synchronous speed; (5) output voltage waveform with less than five percent total harmonic distortion; and (6) damping of simulated drive train resonance at 0.2 Hz.« less
Opioid overdose prevention and naloxone distribution in Rhode Island. (2011)

Opioid overdose is a major public health concern that affects a diverse group of individuals across all categories of race, class, and geography.1 Overdose is the leading cause of adult accidental death in Rhode Island, making our state one of only 16 where overdose mortality exceeds that of motor vehicle accidents.2 Drug-related deaths, of which overdose is the largest component, claimed the lives of 193 Rhode Islanders in 2008.3

Opioid overdose (OD) occurs when opioids bind receptors in the brain stem, diminishing sensitivity to carbon dioxide and ultimately resulting in respiratory failure. Naloxone Hydrochloride (brand name Narcan®) is an opioid antagonist capable of reversing overdose due to opioids, such as heroin or prescription opioids.4 Naloxone has no potential for abuse; its only major contraindication, allergic reaction to prior administration, is rare.5 For more than three decades, emergency medical personnel have administered naloxone as a standard pre-hospital treatment for opioid overdose.4 Naloxone has been available, by prescription, to at-risk drug users and their family/friends since 1999 through select programs across the country.

A common argument against the provision of naloxone to at-risk injection drug users (IDUs) is that the availability of naloxone will increase their risk behavior. To the contrary, Seal et al. observed a decline in heroin use in participants enrolled in their naloxone (and resuscitation) intervention in San Francisco, with a simultaneous increase in overdose prevention knowledge.6

In two different studies of drug users in Rhode Island, the majority expressed a willingness to administer naloxone to a peer in the event of an overdose.7–8 Evaluations of naloxone interventions in major US cities, including San Francisco, Baltimore, Chicago, and New York, have found a notable increase in overdose knowledge among drug users trained in opioid OD recognition and response, dissemination of this knowledge through peer networks, and successful usage of naloxone by study participants.9

Massachusetts instituted a statewide pilot OD prevention program in late 2007, which is operated by the Department of Public Health (DPH). The DPH purchases naloxone and distributes it to training centers, monitors the program, and tracks participant enrollment and naloxone use. The medical director has issued a standing order that allows non-medical personnel to distribute naloxone to trained lay responders in the community without a prescription. In Wilkes County, North Carolina, Project Lazarus began distributing naloxone through physicians in 2010, in collaboration with the state Medical Board. Naloxone is prescribed and distributed by physicians when patients with documented risk factors for overdose are prescribed opioid medications.

This paper presents an overview and pilot evaluation of PONI (Preventing Overdose and Naloxone Intervention), the opioid overdose prevention program in Rhode Island.
Resolution in QCM Sensors for the Viscosity and Density of Liquids: Application to Lead Acid Batteries (2012)

In battery applications, particularly in automobiles, submarines and remote communications, the state of charge (SoC) is needed in order to manage batteries efficiently. The most widely used physical parameter for this is electrolyte density. However, there is greater dependency between electrolyte viscosity and SoC than that seen for density and SoC. This paper presents a Quartz Crystal Microbalance (QCM) sensor for electrolyte density-viscosity product measurements in lead acid batteries. The sensor is calibrated in H(2)SO(4) solutions in the battery electrolyte range to obtain sensitivity, noise and resolution. Also, real-time tests of charge and discharge are conducted placing the quartz crystal inside the battery. At the same time, the present theoretical "resolution limit" to measure the square root of the density-viscosity product [Formula: see text] of a liquid medium or best resolution achievable with a QCM oscillator is determined. Findings show that the resolution limit only depends on the characteristics of the liquid to be studied and not on frequency. The QCM resolution limit for [Formula: see text] measurements worsens when the density-viscosity product of the liquid is increased, but it cannot be improved by elevating the work frequency.
Guest Editorial Introducing Perception, Planning, and Navigation for Intelligent Vehicles (2009)

The nine papers in this special section examine perception, planning, and navigation for intelligent vehicles.
Electrogastrography. (2006)

Electrogastrography (EGG) is the recording and the interpretation of gastric electrical activity. Recordings can be made from the gastrointestinal mucosa, serosa, or skin surface. Because of its ease of use, cutaneous EGG has gained wide acceptance. Many technical problems have been solved to obtain a good graph. The EGG is usually evaluated in terms of changes in the EGG waves amplitude and frequency. Deviations from the normal frequency of 3 cycles per minute may be referred to as brachy- or tachyarrhythmia. The clinical use of EGG has been most widely evaluated in patients with gastroparesis and functional dyspepsia. Scintigraphic gastric emptying is considered the gold standard test for evaluating gastroparesis and 13C-octanoate breath test an ideal alternative because does not use ionizing radiation. While gastric emptying evaluates the efficiency of gastric emptying, EGG focuses on the underlying myoelectrical activity. Using both EGG and 13C-octanoate breath test will be possible to detect many subset of dyspeptic patients and to understand the underlying problem.
SimplE Embedding for Link Prediction in Knowledge Graphs (2018)

Knowledge graphs contain knowledge about the world and provide a structured representation of this knowledge. Current knowledge graphs contain only a small subset of what is true in the world. Link prediction approaches aim at predicting new links for a knowledge graph given the existing links among the entities. Tensor factorization approaches have proved promising for such link prediction problems. Proposed in 1927, Canonical Polyadic (CP) decomposition is among the first tensor factorization approaches. CP generally performs poorly for link prediction as it learns two independent embedding vectors for each entity, whereas they are really tied. We present a simple enhancement of CP (which we call SimplE) to allow the two embeddings of each entity to be learned dependently. The complexity of SimplE grows linearly with the size of embeddings. The embeddings learned through SimplE are interpretable, and certain types of background knowledge can be incorporated into these embeddings through weight tying. We prove SimplE is fully expressive and derive a bound on the size of its embeddings for full expressivity. We show empirically that, despite its simplicity, SimplE outperforms several state-of-the-art tensor factorization techniques. SimplE's code is available on GitHub at https://github.com/Mehran-k/SimplE.
Sensor systems for lower limb functional electircal stimulation (FES) control (2000)

Two sensor systems comprising clusters of accelerometers, magnetic sensors, a rate gyroscope, and a strain gauge were designed. For one system, the clusters were located at the belt and AFO. In the other system, the clusters were located at the AFO and the thigh. The maximum cluster size was 14 cm(3) and 75 g. The clusters of each sensor system were interconnected by a single flexible wire bus, which minimized the effects of cabling. The sensors detected five phases of normal gait to a resolution of 40 ms in an able bodied test. Using a threshold method, the sensor system repeatedly predicted an incipient knee buckle in a paraplegic individual by a minimum of 30 ms. One system detected knee flexion angle analytically to an accuracy of 3.2 degrees during sit to stand trials. The second system determined knee and hip flexion angle to an accuracy of 3.8 degrees during sit to stand trials through neural networks. The signal processing of the acquired sensor signals in each system was performed on a MC68332 microcomputer in conjunction with the data sampling, and suggested the possibility for each sensor system to be used in real time control of FES.
Conversion of hydrogen-bonded manganese(<scp>II</scp>) and zinc(<scp>II</scp>) squarate (C<sub>4</sub>O<sub>4</sub><sup>2–</sup>) molecules, chains and sheets to three-dimensional cage networks (1995)

Very strong hydrogen-bonding interactions can be utilized to guide the assembly of the molecular building block [Mn(HC4O4)2(OH2)4](H2C4O4= squaric acid, 3,4-dihydroxycyclobut-3-ene-1,2-dione) in the crystal. X-Ray structural analysis of these crystals [triclinic, P, a= 5.1910(4), b= 7.4605(7), c= 8.9088(11)Å, α= 67.07(1), β= 77.23(1), γ= 74.49(1)°, Z= 1] revealed the presence of two very short hydrogen-bonding contacts, O–H ⋯ O = 2.464(1) and 2.481(1)Å, which are responsible for the formation of chains and sheets of manganese squarates(1–) in the crystal. Additional hydrogen-bonding contacts that are weaker but numerous are present and they lead to the formation of a strongly associated three-dimensional manganese squarate(1–) network. The complexity of this hydrogen-bonding pattern was simplified by substituting, in the zinc analogue, two water molecules with dmso (dmso = dimethyl sulfoxide) to give [Zn(C4O4)(OH2)2(dmso)2], which was characterized by single-crystal X-ray diffraction [monoclinic, P21/c, a= 15.697(6), b= 8.116(4), c= 12.211(5)Å, β= 115.83(3)°, Z= 4]. Here, extended chains of zinc squarate are present and found to be linked together by hydrogen bonds to form a layered solid. Further growth of this structure to produce a three-dimensional framework was prevented by virtue of the dmso ligands occupying axial positions at the zinc centre. The ability of the hydrogen bonds to act collectively over a large surface area of these solids adds to their overall crystal stability, as these compounds are insoluble at room temperature in aqueous and non-aqueous media. However, in aqueous media at 25–100°C they undergo conversion reactions leading to the known extended three-dimensional cage network M(C4O4)(OH2)2(M = Mn or Zn).
Fibrillarin: a new protein of the nucleolus identified by autoimmune sera (1985)

Autoimmune serum from a patient with scleroderma was shown by indirect immunofluorescence to label nucleoli in a variety of cells tested including: rat kangaroo PtK2, Xenopus A6, 3T3, HeLa, and human peripheral blood lymphocytes. Immunoblot analysis of nucleolar proteins with the scleroderma antibody resulted in the labeling of a single protein band of 34 kD molecular weight with a pI of 8.5. Electron microscopic immunocytochemistry demonstrated that the protein recognized by the scleroderma antiserum was localized exclusively in the fibrillar region of the nucleolus which included both dense fibrillar and fibrillar center regions. Therefore, we have named this protein "fibrillarin". Fibrillarin was found on putative chromosomal nucleolar organizer regions (NORs) in metaphase and anaphase, and during telophase fibrillarin was found to be an early marker for the site of formation of the newly forming nucleolus. Double label indirect immunofluorescence and immunoelectron microscopy on normal, actinomycin D-segregated, and DRB-treated nucleoli showed that fibrillarin and nucleolar protein B23 were predominantly localized to the fibrillar and granular regions of the nucleolus, respectively. RNase A and DNase I digestion of cells in situ demonstrated that fibrillarin was partially removed by RNase and completely removed by DNase. These results suggest that fibrillarin is a widely occurring basic nonhistone nucleolar protein whose location and nuclease sensitivity may indicate some structural and/or functional role in the rDNA-containing dense fibrillar and fibrillar center regions of the nucleolus.
Production of a nisin-like bacteriocin by Lactococcus lactis subsp. lactis A164 isolated from Kimchi (2000)

Lactococcus lactis subsp. lactis A164 was isolated from Kimchi (Korean traditional fermented vegetables). The bacteriocin produced by strain A164 was active against closely related lactic acid bacteria and some food-borne pathogens including Staphylococcus aureus, Listeria monocytogenes and Salmonella typhimurium. The antimicrobial spectrum was nearly identical to that of nisin. Bacteriocin activity was not destroyed by exposure to elevated temperatures at low pH values, but the activity was lost at high pH values. This bacteriocin was inactivated by pronase E and alpha, beta-chymotrypsin, but not by trypsin, pepsin, and alpha-amylase. Cultures of L. lactis subsp. lactis A164 maintained at a constant pH of 6.0 exhibited maximum production of the bacteriocin. It was purified to homogeneity by ammonium sulphate precipitation, sequential ion exchange chromatography, and ultrafiltration. Tricine-SDS-PAGE of purified bacteriocin gave the same molecular weight of 3.5 kDa as that of nisin. The gene encoding this bacteriocin was amplified by PCR with nisin gene-specific primers and sequenced. It showed identical sequences to the nisin gene. These results indicate that bacteriocin produced by Lactococcus lactis A164 is a nisin-like bacteriocin.