Leprosy, Hypercalcemia, and Elevated Serum Calcitriol Levels (1986)

Brief Reports1 December 1986Leprosy, Hypercalcemia, and Elevated Serum Calcitriol LevelsVlCKl N. HOFFMAN, M.D., OKSANA M. KORZENIOWSKI, M.D.VlCKl N. HOFFMAN, M.D.Search for more papers by this author, OKSANA M. KORZENIOWSKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-6-890 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIncreased calcitriol levels have been reported in patients who have hypercalcemia with sarcoid and other granulomatous diseases, which suggests that calcidiol 1-alpha-hydroxylase is produced extrarenally (1, 2). Granulomatous tissue from patients with sarcoid diseases has been shown subsequently to secrete an active calcitriol-like metabolite in vitro (3, 4). Hypercalcemia recently was documented in a patient with leprosy and suppressed calcitriol levels (5). We report the case of a patient who had leprosy, hypercalcemia, and elevated calcitriol levels.A 53-year-old East-Indian woman had emigrated to the United States 4 years before hospitalization for repair of traumatic fractures of the right proximal...References1. BELLSTERNPANTZERSINHADELUCA NPETH. Evidence that increased circulating 1 alpha 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J Clin Invest. 1979;64:218-25. CrossrefMedlineGoogle Scholar2. BARBOURCOBURNSLATOPOLSKYNORMANHORST GJEAR. Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1, 25-dihydroxyvitamin D. N Engl J Med. 1981;305:440-3. CrossrefMedlineGoogle Scholar3. ADAMSSHARMAGACADSINGER JOMF. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest. 1983;72:1856-60. CrossrefMedlineGoogle Scholar4. MASONFRANKELCHANLISSNERPOSEN RTYDS. Vitamin D conversion of sarcoid lymph node homogenate. Ann Intern Med. 1984;100:59-61. LinkGoogle Scholar5. RYZENSINGER EF. Hypercalcemia in leprosy. Arch Intern Med. 1985;145:1305-6. CrossrefMedlineGoogle Scholar6. LEMANNGRAY JR. Calcitriol, calcium, and granulomatous disease [Editorial]. N Engl J Med. 1984;311:1115-7. CrossrefMedlineGoogle Scholar7. KENNEDYALLAMROONEY ARP. Hypercalcemia in rheumatoid arthritis: investigation of its causes and implications. Ann Rheum Dis. 1979;38:401-12. CrossrefMedlineGoogle Scholar8. Rheumatic manifestations in leprosy [Editorial], Lancet. 1981;1:648-9. MedlineGoogle Scholar9. MATTHEWSTRAUTMAN LJ. Clinical and serological profiles in leprosy. Lancet. 1965;2:915-7. CrossrefMedlineGoogle Scholar10. MARIGLIOHYDEO'HANLON JRE. Hypercalcemia following bone surgery in a patient with stable pulmonary sarcoidosis. Chest. 1983;84:299-300. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Medical College of Pennsylvania Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCase Report: Hypercalcemia in an Older Patient with Type I Lepra ReactionVDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian populationRegulation of Renal and Extrarenal 1α-HydroxylaseVitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and TreatmentHypercalcemia Associated with Local and Ectopic Hormone ProductionLeprosy, a neglected disease that causes a wide variety of clinical conditions in tropical countriesExtrarenal CYP27B1 and Vitamin D PhysiologyRole of the Vitamin D in LeprosyExtrarenal 1α-HydroxylaseRare Causes of Calcitriol-Mediated Hypercalcemia: A Case Report and Literature ReviewManagement of Parathyroid DisordersEndocrine dysfunction in leprosyAltered fluid, electrolyte and mineral status in tropical disease, with an emphasis on malaria and leptospirosisDisorders of Calcium MetabolismVitamin DAcute Renal Failure and HypercalcemiaExtra-renal 1α-Hydroxylase Activity and Human DiseaseHypercalcemia Secondary to LeprosyEvaluation of the Hypercalcemic PatientHypercalcemia Associated with Infection by Cryptococcus neoformans and Coccidioides immitisHypercalcemia Associated with Infection by Cryptococcus neoformans and Coccidioides immitisSarcoidosis and Related DisordersElevated 1,25-dihydroxyvitamin D serum concentrations in infants with subcutaneous fat necrosisCalcium and vitamin D metabolism in granulomatous diseasesBibliographyHypercalcemia and vitamin d metabolism in Hodgkin's disease. Is there an underlying immunoregulatory relationship?Unusual Causes of HypercalcemiaThe Role of the Vitamin D Endocrine System in Health and DiseaseMineral MetabolismINTERACTION BETWEEN THE HEMATOPOIETIC SYSTEM AND THE VITAMIN D ENDOCRINE SYSTEMHypercalcemia and abnormal 1,25-dihydroxyvitamin D concentrations in leprosy 1 December 1986Volume 105, Issue 6Page: 890-891KeywordsCalcitriolHospitalizationsHypercalcemiaLeprosyMetabolites Issue Published: 1 December 1986 PDF DownloadLoading ...