gebhart/patrepeval huggingface dataset:
VIP Inhibits <i>Porphyromonas gingivalis</i> LPS-induced Immune Responses in Human Monocytes (2005)

Lipopolysaccharide (LPS) from the Gram-negative pathogen Porphyromonas gingivalis (Pg) stimulates cytokine secretion in immune cells, and thereby initiates the inflammation associated with periodontitis. Modulation of pro-inflammatory cytokine activity is a plausible therapeutic target in periodontal disease. Vasoactive intestinal peptide (VIP) has a role in immunoregulation, and has been identified as a molecule with therapeutically beneficial immunosuppressive effects in inflammatory and autoimmune conditions. We aimed to investigate the effect of VIP on immune responses induced by Pg LPS in vitro. VIP (10(-8) M) significantly (P < 0.05) inhibits TNF-alpha production by human monocytic THP1 cells stimulated with Pg LPS. In parallel, we showed that VIP inhibits nuclear translocation of NFkappaB and c-Jun in a time-dependent manner, but does not decrease the expression of CD14 receptors. This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes.
Identification of humanoid robots dynamics using floating-base motion dynamics (2008)

When simulating and controlling robot dynamics it is necessary to know the inertial parameters and the joint dynamics accurately. As these parameters are usually not provided by manufacturers, identification is then an essential step in robotics. In addition with the up coming wide-spreading of humanoid robots in the society the identification of humanoid dynamics has became mandatory to insure safety. This paper proposes a method to estimate humanoid robots inertial parameters using a minimal set of sensors. Only joint angles and external forces information are required. Simulations have provided exciting trajectories that are reproduced on a small-size humanoid robot. Experimental results are given.
Inhibition of Complement Activation Decreases Airway Inflammation and Hyperresponsiveness (2003)

Abstract Studies in murine models have suggested the involvement of the complement anaphylatoxins (C3a and C5a) in the development of allergic asthma. We investigated the effects of inhibiting complement activation after sensitization but before allergen challenge on the development of allergic airway inflammation and airway hyperresponsiveness. To prevent complement activation, we used a recombinant soluble form of the mouse membrane complement inhibitor complement receptor-related gene y (Crry) fused to the IgG1 hinge, CH2 and CH3 domains (Crry-Ig), which has decay-accelerating activity for both the classic and alternative pathways of complement as well as cofactor activity for factor I-mediated cleavage of C3b and C4b. C57BL/6 mice were sensitized (Days 1 and 14) and challenged (Days 24–26) with ovalbumin. Crry-Ig was administered after allergen sensitization either as an intraperitoneal injection or by nebulization before allergen challenge. Crry-Ig significantly prevented the development of airway hyperresponsiveness, decreased airway and lung eosinophilia as well as the numbers of lung lymphocytes, decreased levels of interleukin (IL)-4, IL-5, and IL-13 in bronchoalveolar lavage fluid and decreased serum ovalbumin-specific IgE and IgG1. These results suggest that prevention of complement activation may have a therapeutic role in the treatment of allergic airway inflammation and asthma in sensitized individuals.
Reduction Behavior of the Mixture of Iron Ore and Carbonaceous Material at High Temperatures (2001)

Reduction and gasification rates of mixtures of fine iron are and coal char were measured for some types of coal char and ore at temperature from 940°C to 1340°C. Experiments were carried out with an electric furnace by measuring weight losses of samples and gas composition during reaction. The reduction rates were obtained by separating the weight loss of the fine iron ore reduction from that of the coal char gasification. The overall reduction rate of the mixture was controlled by the coal char gasification at 940°C and by the iron ore reduction at 1340°C. The reduction rate of fine iron ore and the gasification rate of coal char were formulated as functions of the particle size, type of raw material, and temperature.
Optimal power allocation in CDMA forward link using dependency between pilot and traffic channels (1999)

This paper shows a new method for minimizing the transmit power on CDMA forward link channels. Different from previous works, the proposed method uses the dependency that exists between the respective signal qualities of the pilot channel and traffic channels. Since present CDMA forward link exploits coherent demodulation with continuously transmitting pilot signals, the stronger the pilot channel is, the less traffic power may be required while the same transmission quality is maintained. With laboratory tests, the dependency is graphed. And then an optimal pilot signal quality is found, which minimizes the total transmit power. Considering various mobile environments, -10 dB is an outstanding choice for the pilot signal quality. This solution can be directly applied to maximize the capacity of CDMA cellular and PCS systems or improve the service quality at the cell edge.
Rapid identification of female carriers of DMD/BMD by quantitative real-time PCR (2004)

Recently developed PCR systems offer online-monitoring of amplification and allow simple and reliable DNA quantification. We have used the LightCycler system to develop a simple and rapid method for direct identification of female carriers of deletions and duplications in the dystrophin gene. The challenge resides in the ability to identify the presence of a deleted or duplicated allele over the background contributed by the normal allele. Quantification is based on the determination of the ratio between potentially deleted/duplicated dystrophin exons and non-deleted/-duplicated reference exons using the unspecific dsDNA-dye SYBRgreen I. In a retrospective study, we evaluated our method in female relatives of DMD/BMD patients with known carrier status by comparative analysis of deleted or duplicated versus non-deleted/-duplicated exons. Carrier status was accurately attributed in 100% of cases, the mean ratios being 0.52+/-0.12 for deletion carriers (expected value: 0.5) and 1.56+/-0.18 for duplication carriers (expected value: 1.5) vs. 1.022+/-0.17 for non-carriers (expected value: 1.0). The method proved to be simple, rapid, reliable, and cost-effective. It may be used for direct determination of deletions/duplications in potential DMD/BMD carriers and may easily be adapted for other genetic conditions involving deletions and duplications.
PP.02.03 (2015)

Objective: It has been reported that persons with prehypertension have increased risk of developing hypertension and prehypertension is associated with an increase in cardiovascular morbidity and mortality compared with normal BP. The aim of our study was to assess the risk factors for prehypertension in Xinjiang uygur population. Design and method: Across-section study was conducted in a Xinjiang Uygur population (438 males and 716 females, aged 30 to 70 years). The fasting lipid profiles, serumglucose, insulin, and uric acid were determined. Homeostasis model assessment insulin resistance index (HOMA-IR) was used to assess insulin resistance (IR). Binary logistic regression analysis was performed to determine risk factors for prehypertension. Blood pressure levels of normotensives and prehypertensives in different body mass index (BMI) categories were compared. Results: Binary logistic regression analysis performed after adjustment for gender, lipids profiles, waist-to-hipratio, uric acid, HOMA-IR, and lifestyle (alcohol drinking and smoking) showed a significantly increasing prevalence of prehypertension with BMI. The odds ratios for prehypertension against the lowest BMI group (separated by 24and 28) were 1.934 and 2.490 (95% confidence interval:1.435∼2.606 and1.825∼3.399, respectively). Age was independently correlated to the increasing prevalence of prehypertension. HOMA-IR was not associated with prehypertensive. The mean diastolic blood pressure (DBP) were significantly increased with BMI categories in either normotensives or prehypertensives (P < 0.001) while the mean systolic blood pressure (SBP) was significantly increased with BMI only in normotensives (P < 0.001). Conclusions: In Xinjiang Uygurs, BMI and age were the risk factors for prehypertension. DBP was significantly increased with BMI. IR was not associated with prehypertension. These findings emphasize the importance of management of obesity for the control of blood pressure and other cardiovascular complications.
Penetration of cefuroxime into the cerebrospinal fluid of patients with traumatic brain injury (1996)

Cefuroxime levels were measured in cerebrospinal fluid (CSF) and serum of four patients with traumatic brain injury following the implantation of intraventricular catheters. The levels ranged from 0.15 to 2.03 micrograms/mL in CSF and from 1.8 to 66.9 micrograms/mL in serum. No ventriculostomy related infections were detected.
Coding and Information Theory (1980)

Coding and information theory , Coding and information theory , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
A complete guide to Linux process scheduling (2015)

The subject of this thesis is process scheduling in wide purpose operating systems. For many years kernel hackers all over the world tried to accomplish the seemingly infeasible task of achieving good interaction on desktop systems and low latencies on heavily loaded server machines. Some progress has been made in this area since the rise of free software, but, in opinion of many, it is still far from perfect. Lots of beginner operating system enthusiasts find the existing solutions too complex to understand and, in light of almost complete lack of documentation along with common hostility of active kernel developers towards rookies, impossible to get hands on.\n\nAnyone who has the courage to wade into the dragon infested layer that is the scheduler, should be aware of the ideas behind current implementations before making any contributions. That is what this thesis is about showing how things work under the hood and how they developed to be like this. Every decision behind each concept in a kernel of an OS has its history and meaning. Here I will guide you through process scheduling mechanisms in currently stable Linux kernel as an object lesson on the matter. \n\nThe work starts with an overview of the essentials of process abstraction in Linux, and continues with detailed code-level description of scheduling techniques involved in past and present kernels.
Low-cost inkjet-printed fully passive RFID tags using metamaterial-inspired antennas for capacitive sensing applications (2013)

A fully passive, compact, and low-cost capacitive wireless RFID-enabled sensing system for capacitive sensing and other Internet of Things applications is proposed. The proposed RFID tag antenna based sensor consists of a closely spaced two-element dipole RFID tag antenna array with a printed capacitive sensor connected to one of the tags. A metamaterial-inspired resonator is used to improve isolation among the two antennas and optimize the size of the antenna structure. When high permittivity materials, such as water or human fingers, are close to the on-tag meander line structure, only one of the RFID chips is able to respond due to the capacitance change, and consequently, detuning of the antenna structure. Therefore the system can distinguish capacitance change using just one fixed operation frequency. All components except from the RFID chips are inkjet-printed on photo-paper using a silver nano-particle ink. The tag dimensions are 84mm × 89mm and the tag is compatible with EPC Class 1 Gen 2 (UHF) standard reader at 915 MHz. Measurements using a commercial RFID reader are used to demonstrate the operation of the fabricated prototype.
Tax cuts, employment and asset prices: A real intertemporal model (2002)

We determine the effects of a delayed or immediate tax cut with or without a "sunset" feature in a real customer-market, non-Ricardian economy. Our model incorporates both the supply-sider channel as well as the Feldstein-Rubin-Summers channel. We show that a tax cut may depress both the real asset price and employment. The presence of the paradoxical result of employment contraction does not work through nor imply an immediate increase of the long real interest rate, contrary to financial commentators. A similar analysis applies to the huge pension problem burdening several continental European economies so part of their high unemployment of late may be ascribed to their looming pension outlays.
Facile and efficient synthesis of thiosemicarbazone derivatives with functionalized pendant amines. (2019)

Bis-thiosemicarbazones are an important class of ligands for the synthesis of transition metal complexes with applications in medicine and electrochemistry.1,2 Among the most studied of these complexation ligands is diacetyl-2,3-bis(N4-methyl-3-thiosemicarbazone) (denoted as ATSM, 1, Figure 1).2,3 Derivatives of 1 with various amines in place of the methylamine of ATSM have previously been reported, including diacetyl (N4-methylthiosemicarbazone-N4′-dimethylthio-semicarbazone) (denoted as ATSM/DM, 2).4 In this work, we pursue the development of a library of ATSM derivatives with a variety of functionalized pendant amines with a range of electronic and steric properties through the transamination of 2 with primary amines (molecules with an –NH2 group). The synthesis, yields, melting points, and 1H NMR spectra of a variety of new ATSM derivative ligands are reported.
An Egg Apparatus-Specific Enhancer of Arabidopsis, Identified by Enhancer Detection (2005)

Despite a central role in angiosperm reproduction, few gametophyte-specific genes and promoters have been isolated, particularly for the inaccessible female gametophyte (embryo sac). Using the Ds-based enhancer-detector line ET253, we have cloned an egg apparatus-specific enhancer (EASE) from Arabidopsis (Arabidopsis thaliana). The genomic region flanking the Ds insertion site was further analyzed by examining its capability to control gusA and GFP reporter gene expression in the embryo sac in a transgenic context. Through analysis of a 5' and 3' deletion series in transgenic Arabidopsis, the sequence responsible for egg apparatus-specific expression was delineated to 77 bp. Our data showed that this enhancer is unique in the Arabidopsis genome, is conserved among different accessions, and shows an unusual pattern of sequence variation. This EASE works independently of position and orientation in Arabidopsis but is probably not associated with any nearby gene, suggesting either that it acts over a large distance or that a cryptic element was detected. Embryo-specific ablation in Arabidopsis was achieved by transactivation of a diphtheria toxin gene under the control of the EASE. The potential application of the EASE element and similar control elements as part of an open-source biotechnology toolkit for apomixis is discussed.
Bone loss and the aromatase inhibitors (2005)

The increasing use of systemic adjuvant therapies has considerably improved the prognosis from early breast cancer. However, some of these therapies affect bone metabolism, resulting in osteoporosis. Aromatase inhibitors lower circulating oestrogen levels to almost unrecordable levels in postmenopausal women, predisposing them to bone loss with an increase in fracture risk. Ongoing clinical trials are favouring the use of the aromatase inhibitors over tamoxifen and this may advocate greater use of these drugs in the future. Strategies for the identification and management of treatment-induced bone loss are currently being defined.
Protecting Podocytes: A Key Target for Therapy of Focal Segmental Glomerulosclerosis (2018)

The podocyte is central to the glomerular filtration barrier and is particularly vulnerable because of its highly differentiated post-mitotic phenotype. The progressive structural changes involved in the pathology of FSGS include podocyte foot process effacement, death of podocytes and exposure of the glomerular basement membrane, filtration of nonspecific plasma proteins, expansion of capillaries, misdirected filtration at points of synechiae, and mesangial matrix proliferation. Although damage to and death of podocytes can result from single-gene disorders, evidence also suggests a role for soluble factors, such as soluble urokinase-type plasminogen activator receptor, cardiotrophin-like cytokine-1, and anti-CD40 antibodies, that promote FSGS recurrence post transplant. Several classes of medications, including corticosteroids, calcineurin inhibitors, endothelin receptor antagonists, adrenocorticotropic hormone, and rituximab, have been shown to be effective for the treatment of FSGS and have been demonstrated to have significant protective effects on podocytes. Key Messages: Greater understanding of podocyte biology is essential to the identification of new treatment targets and medications for the management of patients with FSGS.
GLYCOGEN SYNTHASE KINASE-3β INHIBITORS PROTECT AGAINST THE ORGAN INJURY AND DYSFUNCTION CAUSED BY HEMORRHAGE AND RESUSCITATION (2006)

Glycogen synthase kinase 3beta (GSK-3beta) is a serine/threonine protein kinase that has recently emerged as a key regulatory switch in the modulation of the inflammatory response. Dysregulation of GSK-3beta has been implicated in the pathogenesis of several diseases including sepsis. Here we investigate the effects of 2 chemically distinct inhibitors of GSK-3beta, TDZD-8 and SB216763, on the circulatory failure and the organ injury and dysfunction associated with hemorrhagic shock. Male Wistar rats were subjected to hemorrhage (sufficient to lower mean arterial blood pressure to 35 mmHg for 90 min) and subsequently resuscitated with shed blood for 4 h. Hemorrhage and resuscitation resulted in an increase in serum levels of (a) creatinine and, hence, renal dysfunction, and (b) alanine aminotransferase and aspartate aminotransferase and, hence, hepatic injury. Treatment of rats with either TDZD-8 (1 mg/kg, i.v.) or SB216763 (0.6 mg/kg, i.v.) 5 min before resuscitation abolished the renal dysfunction and liver injury caused by hemorrhagic shock. In addition, TDZD-8, but not SB216763, attenuated the increase caused by hemorrhage and resuscitation in plasma levels of the proinflammatory cytokine interleukin 6 and also of the anti-inflammatory cytokine interleukin 10. Neither of the GSK-3beta inhibitors however affected the delayed fall in blood pressure caused by hemorrhagic shock. Thus, we propose that inhibition of GSK-3beta may represent a novel therapeutic approach in the therapy of hemorrhagic shock.
Development of enzalutamide for metastatic castration‐resistant prostate cancer (2015)

Prostate cancer is the most prevalent cancer among men in the Western world and a leading cause of cancer-related death among men. Within 5 years of initial diagnosis, approximately 10-20% of men will progress to metastatic castration-resistant prostate cancer (mCRPC). Often characterized by increased prostate-specific antigen and androgen receptor (AR) activity despite castrate levels of testosterone, mCRPC has a poor prognosis and causes significant deterioration in quality of life. Enzalutamide is an AR inhibitor approved to treat mCRPC in both post- and pre-chemotherapy settings on the basis of results from two phase III randomized, placebo-controlled trials, AFFIRM and PREVAIL, respectively. Enzalutamide significantly prolonged overall survival (hazard ratio (HR), AFFIRM 0.63, 95% confidence interval (CI) 0.53-0.75, P < 0.001; PREVAIL 0.71, 95% CI 0.60-0.84, P < 0.001) and radiographic progression (HR, AFFIRM 0.40, 95% CI 0.35-0.47, P < 0.001; PREVAIL 0.19, 95% CI 0.15-0.23, P < 0.001), and significantly improved quality of life. With an acceptable safety profile, enzalutamide is one of several emerging alternative options for men with mCRPC. Studies are ongoing to explore potential benefits of enzalutamide in earlier stages of prostate cancer and in breast cancer.
A Comparison Of Techniques For Color Gamut Mismatch Compensation (1989)

Motivated by an increase in aesthetic value and information content, an increasing number of daily activities once performed in monochrome are being converted to color. As a result, the display and printing of color images is becoming an increasingly important topic. An often overlooked limitation of the color display or printing process is that of color gamut mismatch. We investigate both clipping and compression techniques for compensation of one type of color gamut mismatch. Image independent and image dependent algorithms using both linear and nonlinear compression techniques are considered. The lightness, saturation, and hue attributes of color are varied among the techniques in order to better understand in which attributes gamut mismatch errors are least perceptible.
Switching a Replication-Defective Adenoviral Vector into a Replication-Competent, Oncolytic Adenovirus (2013)

The adenovirus immediate early gene E1A initiates the program of viral gene transcription and reprograms multiple aspects of cell function and behavior. For adenoviral (Ad) vector-mediated gene transfer and therapy approaches, where replication-defective (RD) gene transfer is required, E1A has thus been the primary target for deletions. For oncolytic gene therapy for cancer, where replication-competent (RC) Ad viral gene expression is needed, E1A has been either mutated or placed under tumor-specific transcriptional control. A novel Ad vector that initially infected target tumor cells in an RD manner for transgene expression but that could be "switched" into an RC, oncolytic state when needed might represent an advance in vector technology. Here, we report that we designed such an Ad vector (proAdΔ24.GFP), where initial Ad replication is silenced by a green fluorescent protein (GFP) transgene that blocks cytomegalovirus (CMV)-mediated transcription of E1A. This vector functions as a bona fide E1A-deleted RD vector in infected tumor cells. However, because the silencing GFP transgene is flanked by FLP recombination target (FRT) sites, we show that it can be efficiently excised by Flp recombinase site-specific recombination, either when Flp is expressed constitutively in cells or when it is provided in trans by coinfection with a second RD herpes simplex virus (HSV) amplicon vector. This switches the RD Ad, proAdΔ24.GFP, into a fully RC, oncolytic Ad (rAdΔ24) that lyses tumor cells in culture and generates oncolytic progeny virions. In vivo, coinfection of established flank tumors with the RD proAdΔ24.GFP and the RD Flp-bearing HSV1 amplicon leads to generation of RC, oncolytic rAdΔ24. In an orthotopic human glioma xenograft tumor model, coinjection of the RD proAdΔ24.GFP and the RD Flp-bearing HSV1 amplicon also led to a significant increase in animal survival, compared to controls. Therefore, Flp-FRT site-specific recombination can be applied to switch RD Ad into fully oncolytic RC Ad for tumor therapy and is potentially applicable to a variety of gene therapy approaches.