gebhart/patrepeval huggingface dataset:
Expression of human plasminogen activator inhibitor-2 in the baculovirus expression system. (1995)

A cDNA coding for human plasminogen activator inhibitor-2 (PAI-2) was transferred into the genome of Autographa californica nuclear polyhedrosis virus adjacent to the polyhedrin promoter. Cells infected with recombinant virus synthesized a 43-kDa PAI-2 protein, the majority of which was secreted. The recombinant PAI-2 was identical to native PAI-2 purified from human placenta with respect to interaction with polyclonal antibody and inhibition of urokinase-type plasminogen activator.
Genetic comparisons reveal the same unknown bacterial lineages in Atlantic and Pacific bacterioplankton communities (1995)

The phylogenetic diversity of oligotrophic bacterioplankton communities was compared with 16S ribosomal RNA genes cloned from natural populations. The data reported here extend a previous analysis of a bacterioplankton 16S rRNA clone library with 15 additional nucleic acid clone sequences, to provide information on 60 16S rDNA clones from hydrostation S in the Sargasso Sea. The data were compared to partial sequences of 37 Bacterial 16S rDNA clones reported from a surface picoplankton population collected at the Aloha station in the North Pacific gyre, and partial sequences of 29 Bacterial 1 6S rRNA clones obtained from sites near Bermuda and the western California Current. The results support reports of diverse groups of previously unknown a‐proteobacteria, γ‐proteobacteria, and cyanobacteria in oceanic surface samples. Three novel lineages (SAR 121, 125, 145) of proteobacteria were found. Several genes cloned from the Sargasso Sea were nearly identical to genes cloned from the Pacific samples, suggesting that these previously unrecognized bacteria groups (SAR11, SAR122, SAR86) are distributed widely in the surface waters of subtropical oceans. Two gene clones closely matched nucleotide sequences from the cultivated bacterial species Photobacterium phosphoreum and A lteromonas haloplanktis.
Fiber-format stimulated-Raman-scattering microscopy from a single laser oscillator (2010)

A highly simplified architecture for stimulated-Raman-scattering microscopy is demonstrated, where multiple tunable narrowband picosecond pulses are generated by spectral compression of femtosecond pulses emitted by a single compact Er-fiber oscillator. The system provides high sensitivity (2x10(-7)) and spectral resolution (sub-15 cm(-1)), and it offers an unprecedented flexibility for multicolor imaging.
KBT: Operating System Kernel Level Binary Translation System (2013)

with the diversification of hardware platforms, software compatibility issue has become increasingly prominent. Virtual machine with dynamic binary translation system is the key technology to solve this problem. This paper designs an operating system kernel level virtual machine with binary translation systems (KBT) which is embedded into kernel space as a kernel module. KBT reduces the number of virtual layers of the computer system, and introduces further optimization strategies using kernel mode advantages. Experiment results improves that, KBT’s efficiency is higher than existing binary translation systems about 25%. KBT also has some interfaces to support kernel module translation systems to run complex software, which are hard to run upon existing user space virtual machines.
Fecal microbiota transplantation for the improvement of metabolism in obesity: The FMT-TRIM double-blind placebo-controlled pilot trial (2020)

ClinicalTrials.gov NCT02530385.
Pressureless sintering of silicon nitride with addition of MgO, Al2O3 and/or spinel. (1976)

[in Japanese]
One-cycle control of switching converters (2002)

A pulsed nonlinear control technique, one-cycle control, is introduced. This technique takes advantage of the pulsed and nonlinear nature of switching converters and achieves instantaneous control of the average value of the chopped voltage or current. This technique provides fast dynamic response and good input-perturbation rejection. It is suitable for the control of pulsewidth-modulated (PWM) converters and quasi-resonant converters. The one-cycle control theory is developed based on the analysis of the basic buck converter with conventional feedback control and current-mode control. Experiments were conducted to verify the feasibility of one-cycle control of the buck converter. The dynamic behavior of one-cycle controlled switching converters is studied. The Cuk converter is used as an example for the analysis and experiments. The one-cycle control theory is generalized to control all types of switching converters: constant frequency, constant turn-on time, constant turn-off time, and variable switches.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Own experience with internal iliac and ovarian artery ligation in gynecological and oncological surgeries]. (1998)

Internal illiac and ovarian artery ligation was performed in 7 patients as a life saving measure (group I) and in 12 patients as a prophylactic procedure (group II) in 116 pelvic operations for gynaecological malignancy. The author presents own surgical technique for internal iliac and ovarian arteries ligation. The purpose of analysis was to identify a surgical complications after the ligation in the study groups. Surgical complications in the group of prophylactic ligation were statistically significant low. It is advisable to adopt this procedure as a routine in all difficult pelvic operations, particularly radical operations for gynaecological malignancy.
Drying Eucalypts for Quality: Material Characteristics, Pre-drying Treatments, Drying Methods, Schedules and Optimisation of Drying Quality (1995)

SYNOPSIS Drying today is recognised as a vital element in the value-added processing of solid wood products and there is currently a strong emphasis on improving drying quality and reducing drying costs. Eucalypts with their characteristically high shrinkage and low mass diffusivity values are notoriously difficult to season without degrade, especially backsawn boards. Considering the premium price which can be fetched for appearance-grade timber, this publication reviews the drying characteristics of eucalypts, various possible pre-drying treatments to enhance ultimate quality and drying rate, the most prevalent drying methods/kilns used, drying schedules to achieve optimum drying conditions, and various measures which can be applied to improve drying quality. The major problem in hardwood drying remains the development of economical ways of drying appearance-grade backsawn timber, free of degrade and in various thicknesses.
Tumour-infiltrating bystander CD8<sup>+</sup>T cells activated by IL-15 contribute to tumour control in non-small cell lung cancer (2021)

Thus, the study demonstrates that bystander CD8<sup>+</sup> TILs can be repurposed by IL-15 for tumour immunotherapy.
In Vitro Metabolism of Plant Lignans:  New Precursors of Mammalian Lignans Enterolactone and Enterodiol (2001)

The metabolism of the plant lignans matairesinol, secoisolariciresinol, pinoresinol, syringaresinol, arctigenin, 7-hydroxymatairesinol, isolariciresinol, and lariciresinol by human fecal microflora was investigated to study their properties as mammalian lignan precursors. The quantitative analyses of lignan precursors and the mammalian lignans enterolactone and enterodiol were performed by HPLC with coulometric electrode array detector. The metabolic products, including mammalian lignans, were characterized as trimethylsilyl derivatives by gas chromatography−mass spectrometry. Matairesinol, secoisolariciresinol, lariciresinol, and pinoresinol were converted to mammalian lignans only. Several metabolites were isolated and tentatively identified as for syringaresinol and arctigenin in addition to the mammalian lignans. Metabolites of 7-hydroxymatairesinol were characterized as enterolactone and 7-hydroxyenterolactone by comparison with authentic reference compounds. A metabolic scheme describing the conversion of the most abundant new mammalian lignan precursors, pinoresinol and lariciresinol, is presented. Keywords: Phytoestrogens; lignans; matairesinol; secoisolariciresinol; lariciresinol; pinoresinol; syringaresinol; isolariciresinol; arctigenin; 7-hydroxymatairesinol; mammalian lignans; enterolactone; enterodiol
A correlation between ploidy levels and characters of leaf and flower in Phalaenopsis. (2014)

【Objective】To research the correlation between ploidy levels and main characters in Phalaenopsis. 【Method】Ploidy levels of 85 Phalaenopsis accessions were identified by using squash method,and the length and density of stoma,the length,width and thickness of leaf,the diameter and the number of flowers were also measured. 【Result and conclusion】The results showed that in the 85 accessions there were three diploids(3. 5%),nine triploids(10. 6%) and 73 tetraploids(85. 9%). Stomatal lengths and the length of tetraploid flower were obviously longer than those of diploid and triploid flower,while the density of stoma and the number of flowers were fewer than that of diploid and triploid(P 0. 05). The differences of the stomatal cell length and diameter and the number of flower between diploid and triploid were not significant at 5% level,however,the stomatal density of triploid was less than that of diploid(P 0. 05). The leaf length of tetraploid was significantly longer than that of diploid(P 0. 05),while the difference of leaf length between diploid and triploid or between triploid and tetraploid was not significant(P 0. 05). The difference of leaf width and thickness among diploid,triploid and teraploid were also not significant either(P 0.05).The ploidy levels were,to a large extant,positively associated to stomata length,leaf lengthand flower diameter,but negatively correlated with stomatal density and the number of flowers.
Interleukin 33 as a Mechanically Responsive Cytokine Secreted by Living Cells (2012)

Interleukin 33 (IL-33), a member of the Interleukin 1 cytokine family, is implicated in numerous human inflammatory diseases such as asthma, atherosclerosis, and rheumatoid arthritis. Despite its pathophysiologic importance, fundamental questions regarding the basic biology of IL-33 remain. Nuclear localization and lack of an export signal sequence are consistent with the view of IL-33 as a nuclear factor with the ability to repress RNA transcription. However, signaling via the transmembrane receptor ST2 and documented caspase-dependent inactivation have suggested IL-33 is liberated during cellular necrosis to effect paracrine signaling. We determined the subcellular localization of IL-33 and tracked its intracellular mobility and extracellular release. In contrast to published data, IL-33 localized simultaneously to nuclear euchromatin and membrane-bound cytoplasmic vesicles. Fluorescent pulse-chase fate-tracking documented dynamic nucleo-cytoplasmic flux, which was dependent on nuclear pore complex function. In murine fibroblasts in vitro and in vivo, mechanical strain induced IL-33 secretion in the absence of cellular necrosis. These data document IL-33 dynamic inter-organelle trafficking and release during biomechanical overload. As such we recharacterize IL-33 as both an inflammatory as well as mechanically responsive cytokine secreted by living cells.
Semi-Supervised Super-Resolution (2022)

Super-Resolution is the technique to improve the quality of a low-resolution photo by boosting its plausible resolution. The computer vision community has extensively explored the area of Super-Resolution. However, previous Super-Resolution methods require vast amounts of data for training which becomes problematic in domains where very few low-resolution, high-resolution pairs might be available. One such area is statistical downscaling, where super-resolution is increasingly being used to obtain high-resolution climate information from low-resolution data. Acquiring high-resolution climate data is extremely expensive and challenging. To reduce the cost of generating high-resolution climate information, Super-Resolution algorithms should be able to train with a limited number of low-resolution, high-resolution pairs. This paper tries to solve the aforementioned problem by introducing a semi-supervised way to perform super-resolution that can generate sharp, high-resolution images with as few as 500 paired examples. The proposed semi-supervised technique can be used as a plug-and-play module with any supervised GAN-based Super-Resolution method to enhance its performance. We quantitatively and qualitatively analyze the performance of the proposed model and compare it with completely supervised methods as well as other unsupervised techniques. Comprehensive evaluations show the superiority of our method over other methods on different metrics. We also offer the applicability of our approach in statistical downscaling to obtain high-resolution climate images.
Semantic Event Extraction from Basketball Games using Multi-Modal Analysis (2007)

In this paper, we present a novel multi-modal framework for semantic event extraction from basketball games based on Webcasting text and broadcast video. We propose novel approaches to text analysis for event detection and semantics extraction, video analysis for event structure modeling and event moment detection, and text/video alignment for event boundary detection in the video. Compared with existing approaches to event detection in sports video which rely heavily on low-level features directly extracted from video itself, our approach aims to bridge the semantic gap between low-level features and high-level events and facilitates personalization of the sports video. Promising results are reported on real-world video clips by using text analysis, video analysis and text/video alignment.
Blue Emitting Cationic Iridium Complexes Containing Two Substituted 2-Phenylpyridine and One 2,2'-Biimidazole for Solution-Processed Organic Light-Emitting Diodes (OLEDs) (2012)

Two new blue emitting cationic iridium(III) complexes with two substituted 2-phenlypyridine ligands as main ligands and one 2,2'-biimidazole as an ancillary ligand, <TEX>$[(L1)_2Ir(biim)]Cl$</TEX> (1) and <TEX>$[(L2)_2Ir(biim)]Cl$</TEX> (2), where L1 = 2-(2',4'-difluorophenyl)-4-methylpyridine, L2 = 2-(2',4'-difluoro-3'-trifluoromethylphenyl)-4-methylpyridine and biim = 2,2'-biimidazole, were synthesized for applications in phosphorescent organic light-emitting diodes (PhOLEDs). Their photophysical, electrochemical and electroluminescent (EL) device performances were examined. The photoluminescent (PL) spectra revealed blue phosphorescence in the 450 to 485 nm range with a quantum yield of more than 10%. The iridium(III) compounds studied showed good solubility in organic solvents with no solvatochromism dependent on the solvent polarity. The solution-processed OLEDs were prepared with the configuration, ITO/PEDOT:PSS (40 nm)/mCP:Ir(III) (70 nm)/OXD-7 (20 nm)/LiF (1 nm)/Al (100 nm), by spin coating the emitting layer containing the mCP host doped with the iridium phosphors. The best performance of the fabricated OLEDs based on compound 1 showed an external quantum efficiency of 4.5%, luminance efficiency of 8.52 cd <TEX>$A^{-1}$</TEX> and blue emission with the CIE coordinates (x,y) of (0.16, 0.33).
Effects of Head and Extracranial Injuries on Serum Protein S100B Levels in Trauma Patients (2004)

We conclude that serum S100B is a sensitive marker of brain injury, which correlates with the severity of the injury. Large extracranial injuries also elevate S100B levels. However, S100B has a high negative predictive power, and the finding of a normal S100B value shortly after trauma should thus exclude significant brain injury with a high accuracy.
Hormonal Control of Plasminogen Activator Inhibitor-1 Gene Expression and Production in Human Adipose Tissue: Stimulation by Glucocorticoids and Inhibition by Catecholamines<sup>1</sup> (1999)

Plasma levels of type 1 plasminogen activator inhibitor (PAI-1), a risk factor for cardiovascular disease, are elevated in obese subjects, especially those with omental fat accumulation. We investigated the hormonal control of PAI-1 gene expression and secretion in cultured human adipose tissue. We more particularly focused on the effects of glucocorticoids, insulin, cAMP, and catecholamines in explants from the omental region. The addition of dexamethasone to the culture medium increased PAI-1 secretion in a time-dependent manner for up to 24 h. The stimulation by the glucocorticoid was preceded by a 2-fold rise in PAI-1 messenger ribonucleic acid levels between 4-8 h of culture. The effectiveness of the glucocorticoid was concentration dependent, with a half-maximal effect within a physiological range. This stimulation was also observed in sc fat, but dexamethasone-stimulated as well as basal PAI-1 secretion rates were always higher in omental fat. Unlike dexamethasone, 24-h insulin did not modify PAI-1 secretion while accelerating glucose consumption. In contrast, 24-h cAMP inhibited PAI-1 gene expression and protein production under basal conditions and in the presence of dexamethasone. This inhibition was already detectable after 1 h and was maximal after 4 h at the level of gene expression. It occurred in both omental and sc adipose tissues. Importantly, epinephrine dose dependently inhibited PAI-1 parameters, an effect that was reproduced by isoproterenol. Dexamethasone- and cAMP-induced changes in PAI-1 messenger ribonucleic acid abundance were similar in explants and isolated fat cells. In isolated stromal-vascular cells, only dexamethasone was effective. In conclusion, we provide evidence for a reciprocal regulation of PAI-1 by dexamethasone (positive effector) and cAMP/catecholamines (negative effectors) in cultured human adipose tissue. The stimulation by glucocorticoids could contribute to enhanced production of PAI-1 by adipose tissue and high plasma levels of PAI-1 associated with central obesity and thereby be a link between this disorder and cardiovascular disease. Impaired inhibition by catecholamines could also contribute, as in vivo adipose tissue responses to these hormones are usually blunted in obese individuals.
Western Classical Music in the Minor Mode Is Slower (Except in the Romantic Period) (2009)

Two studies are reported that examine the relationship between musical mode and tempo in Western classical music. In the first study, modes were determined for 331 works bearing the tempo markings largo, adagio, allegro, or presto. Slower tempo markings are significantly more likely to be associated with the minor mode in the case of music from the Baroque and Classical periods, whereas the reverse trend is observed in music from the Romantic period. In the second study, an analysis of 21 audio recordings of theme-and-variation keyboard movements (from all three style periods) shows that variations written in the minor mode are performed more slowly than neighboring variations in the major mode. These tempo-related observations are largely consistent with research in speech prosody, which has shown that sad speakers speak relatively slowly.
Improving outcomes through early diagnosis of Parkinson's disease. (2012)

Current diagnostic modalities in Parkinson's disease (PD) are limited by the fact that they identify PD by the presence of motor symptoms; by this point, over 60 percent of all dopamine neurons within specific regions of the basal ganglia may have been lost. Nonmotor symptoms manifest in PD long before motor symptoms, and the early presence of nonmotor symptoms offers an opportunity for early diagnosis and early treatment of PD, with consequent benefits to patient quality of life and potential treatment cost savings. Numerous different premotor symptoms have been identified; diminished olfactory function and REM behavioral sleep disorders (RBDs) may be particularly suitable for the purposes of early diagnosis. Olfactory testing, while in itself not specific for PD, has been shown to offer very high degrees of sensitivity and specificity in distinguishing PD from healthy controls and from other forms of parkinsonism, particularly when accompanied by other means of detection, such as sonography, motor symmetry evaluation, and magnetic resonance imaging (MRI)/diffusion tensor imaging. Biological biomarkers--including protein panels and autoantibody testing--have demonstrated excellent diagnostic capacity, and a recently identified 5-gene panel has been shown to have high specificity and sensitivity in distinguishing early PD from healthy controls and advanced PD. Increasingly sophisticated neuroimaging techniques are also proving capable of early PD detection and differentiation from other parkinsonian types. These recent developments in PD diagnosis underscore the necessity of rethinking what PD is and how, and when, it can be diagnosed.
The Thermophilic Yeast <i>Hansenula polymorpha</i> Does Not Require Trehalose Synthesis for Growth at High Temperatures but Does for Normal Acquisition of Thermotolerance (1999)

The TPS1 gene from Hansenula polymorpha, which encodes trehalose-6-phosphate (Tre6P) synthase, has been isolated and characterized. The deletion of TPS1 rendered H. polymorpha cells incapable of trehalose synthesis under conditions where wild-type cells normally accumulate high levels of trehalose. Interestingly, the loss of Tre6P synthase did not cause any obvious growth defects on a glucose-containing medium, even at high temperatures, but seriously compromised the cells' ability to acquire thermotolerance.
Simple synthesis method of Bi2S3/CdS quantum dots cosensitized TiO2 nanotubes array with enhanced photoelectrochemical and photocatalytic activity (2013)

A TiO2 nanotubes array film with nanowires directly formed on top (denoted as TiO2 NTWs) was prepared by an anodization method (potentiostatic anodization growth). Bi2S3 QDs were sensitized on the CdS/TiO2 NTWs array by a simple successive ionic layer adsorption and reaction (S-SILAR). A short-circuit photocurrent density of 2.16 mA cm−2 was obtained under an illumination of AM 1.5 G. The data of the photoelectrochemical performance test show that Bi2S3/CdS co-modification can boost the photocurrent density of the bare TiO2 NTWs by up to 308%. The photocatalytic activity was tested by treating rhodamine B (RhB) and methyl orange (MO) solutions, which were degraded completely after 240 min and 210 min, respectively. The present study shows the Bi2S3/CdS/TiO2 NTWs array can be applied in photocatalytic devices, and the greatest advantages are low-cost, easy reuse and recyclability.
Three types of postsynaptic glutamatergic receptors are activated in DMNX neurons upon stimulation of NTS (1996)

While it is widely accepted that parasympathetic activity plays a significant role in cardiovascular, bronchomotor, and gastrointestinal function, little is known about the synaptic control of parasympathetic vagal neurons. In this study, we identified the neurotransmitter(s) and postsynaptic responses in dorsal motor nucleus of the vagus (DMNX) neurons upon stimulation of the nucleus of the solitary tract (NTS). Neurons were visualized in rat brain stem slices, and perforated patch-clamp techniques were used to record postsynaptic currents. NTS stimulation activated glutamatergic currents in DMNX that were separated into N-methyl-D-aspartate (NMDA) and non-NMDA components using D-2-amino-5-phosphonovalerate and 6-cyano-7-nitroquinoxaline-2,3-dione, respectively. The non-NMDA component was further characterized using cyclothiazide and concanavalin A to block desensitization of DL-alpha-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA) and kainate receptors, respectively. Cyclothiazide increased the postsynaptic amplitude, whereas concanavalin A augmented duration, suggesting kainate, but not AMPA, currents are curtailed by desensitization. High frequency stimulations did not alter synaptic efficacy. In conclusion, this study demonstrates the existence of a monosynaptic glutamatergic pathway from NTS that activates NMDA, kainate, and AMPA postsynaptic receptors in DMNX neurons.