gebhart/patrepeval huggingface dataset:
Localization and conditional redundancy of regulatory elements in rbcS-3A, a pea gene encoding the small subunit of ribulose-bisphosphate carboxylase. (1988)

Expression of the pea rbcS-3A gene, one of a family of genes encoding the small subunit of ribulose-bisphosphate carboxylase [EC 4.1.1.39], is regulated by light and is restricted to chloroplast-containing cells. We analyzed the effects of light and development on rbcS-3A expression in transgenic plants. Two highly conserved sequences ("boxes" II and III) around nucleotide position -150 (relative to the transcription initiation site, +1) are required for rbcS-3A expression. The so-defined positive elements overlap with previously identified negative light-regulatory elements. In the case of box II, which has sequence similarity to the core enhancer motif of simian virus 40, a GG----CC transversion is sufficient to abolish expression. The effect of mutations in boxes II and III can only be measured when sequences upstream of -170 are removed, and because sequences both 5' and 3' of -170 can direct light-regulated and organ-specific expression. This implies that there is a redundancy of cis-acting elements in the 5' noncoding region of rbcS-3A. However, we show that the sequences upstream of -170 are dispensable only in the mature leaves of a green plant. In contrast, in the young, expanding leaves at the top of a green plant, as well as in seedlings, the distal elements are required for high-level expression. Therefore, redundancy is not absolute, and the requirements for rbcS-3A expression change during plant development.
P‐15 Cell‐Binding Domain Derived from Collagen: Analysis of MG63 Osteoblastic‐Cell Response by Means of a Microarray Technology (2004)

The data reported are, to our knowledge, the first genetic portrait of P-15 effects. They can help us to better understand the molecular mechanism of osteogenesis and can serve as a model for comparing different cell cultures and/or other materials with similar effect.
Motion and Space Sickness (1990)

Motion Sickness. and Evolution. Kenneth E. Money. The Central Nervous Connections Involved in Motion Induced Emesis. Kenneth R. Brizzee. Neurophysiology of Motion Sickness. George H. Crampton. Role of the Vestibular Endorgans in Experimental Motion Sickness: A Primate Model. Makoto Igarashi. Neurochemistry and Pharmacology of Motion Sickness in Nonhuman Species. James B. Lucot. Endocrinology of Space?Motion Sickness. Randall L. Kohl. Animal Models in Motion Sickness Research. Nancy G. Daunton. Investigating Motion Sickness Using the Conditioned Taste Aversion Paradigm. Robert A. Fox. The Accelerative Stimulus for Motion Sickness. John C. Guignard and Michael E. McCauley. Physiology of Motion Sickness Symptoms. Deborah L. Harm. Prediction of Motion Sickness Susceptibility. Robert S. Kennedy, William Dunlap, and Jennifer E. Fowlkes. Symptoms and Signs of Space Motion Sickness on SPACELAB-1. Charles M. Oman, Byron K. Lichtenberg, and Kenneth E. Money. Adaptation to the Simulated St imulus Rearrangement of Weightlessness. Donald E. Parker and Katherine L. Parker. Statistical Prediction of Space Motion Sickness. Millard F. Reschke. Simulator Sickness. Robert S. Kennedy, Lawrence J. Hettinger, and Michael G. Lilienthal. Pharmacological Countermeasures Against Motion Sickness. Charles D. Wood. Autogenic Feedback Training: A Treatment for Motion Sickness. Patricia S. Cowings. Adaptation to Nauseogenic Motion Stimuli and Its Application in the Treatment of Airsickness. J.R.R. Stott. Motion Sickness Susceptibility and Behavior. Charles S. Mirabili Jr. Motion Sickness and Human Performance. Lawrence J. Hettinger, Robert S. Kennedy, and Michael E. McCauley. Index.
Enhancement of Nab-Paclitaxel Antitumor Activity through Addition of Multitargeting Antiangiogenic Agents in Experimental Pancreatic Cancer (2014)

Nanoparticle albumin-bound paclitaxel (nab-paclitaxel, NPT) has recently shown efficacy in pancreatic ductal adenocarcinoma (PDAC). Targeting tumor angiogenesis is a sensible combination therapeutic strategy for cancer, including PDAC. We tested the hypothesis that NPT response in PDAC can be enhanced by the mechanistically different antiangiogenic agents bevacizumab (Bev) or sunitinib (Su), despite its inherently increased tumor penetration and drug delivery. Compared with controls (19 days), median animal survival was increased after NPT therapy (32 days, a 68% increase, P = 0.0008); other regimens with enhanced survival were NPT+Bev (38 days, a 100% increase, P = 0.0004), NPT+Su (37 days, a 95% increase, P = 0.0004), and NPT+Bev+Su (49 days, a 158% increase, P = 0.0001) but not bevacizumab, sunitinib, or Bev+Su therapy. Relative to controls (100 ± 22.8), percentage net local tumor growth was 28.2 ± 23.4 with NPT, 55.6 ± 18 (Bev), 38.8 ± 30.2 (Su), 11 ± 7.2 (Bev+Su), 32.8 ± 29.2 (NPT+Bev), 6.6 ± 10.4 (NPT+Su), and 13.8 ± 12.5 (NPT+Bev+Su). Therapeutic effects on intratumoral proliferation, apoptosis, microvessel density, and stromal density corresponded with tumor growth inhibition data. In AsPC-1 PDAC cells, NPT IC(50) was reduced >6-fold by the addition of sunitinib (IC(25)) but not by bevacizumab. In human umbilical vein endothelial cells (HUVEC), NPT IC(50) (82 nmol/L) was decreased to 41 nmol/L by bevacizumab and to 63 nmol/L by sunitinib. In fibroblast WI-38 cells, NPT IC(50) (7.2 μmol/L) was decreased to 7.8 nmol/L by sunitinib, but not by bevacizumab. These findings suggest that the effects of one of the most active cytotoxic agents against PDAC, NPT, can be enhanced with antiangiogenic agents, which clinically could relate to greater responses and improved antitumor results.
O Desenvolvimento Moral da Criança (2014)

Em Pediatria é usual abordar o desenvolvimento psicomotor e cognitivo da criança como um índice de saúde e bem estar. O mesmo não se passa com o desenvolvimento da moral que é relativamente desconhecido.A autora identifica e descreve as principais teorias referentes ao desenvolvimento moral, nomeadamente os aspectos cronológicos e sequenciais do processo de aquisição da moralidade, sublinhando a importância da modelação de comportamentos pró-sociais e de alerta para comportamentos de risco através de dinâmicas familiares que privilegiam estilos de comunicação como o discurso empático e de suporte.Conclui que o conhecimento do desenvolvimento da cognição moral é fundamental para os educadores complementarem e aperfeiçoarem a modelação comportamental parental.
The effects of fibronectin on the migration of human foreskin fibroblasts and syrian hamster melanoma cells into three-dimensional gels of native collagen fibres (1981)

The effects of fibronectin on the migration of human skin fibroblasts and Syrian hamster melanoma cells into 3-dimensional gels of native collagen fibres have been examined. Cell migration into the 3-dimensional gel was measured by plating cells on the gel surface and then determining the percentage of cells within the gel at various times thereafter by direct microscopic examination. We find that fibronectin bound to collagen inhibits the migration of human skin fibroblasts and stimulates the migration of melanoma cells into the gel matrix. Fibronectin had no apparent effect on cell adhesion to the collagen gels, proliferation or morphology under the conditions studied.
Quantifying the Carbon Emissions of Machine Learning (2019)

From an environmental standpoint, there are a few crucial aspects of training a neural network that have a major impact on the quantity of carbon that it emits. These factors include: the location of the server used for training and the energy grid that it uses, the length of the training procedure, and even the make and model of hardware on which the training takes place. In order to approximate these emissions, we present our Machine Learning Emissions Calculator, a tool for our community to better understand the environmental impact of training ML models. We accompany this tool with an explanation of the factors cited above, as well as concrete actions that individual practitioners and organizations can take to mitigate their carbon emissions.
Independent association of uric acid levels with peripheral arterial disease in Taiwanese patients with Type 2 diabetes (2004)

Elevated uric acid level is a significant and independent risk factor for PAD in Taiwanese patients with Type 2 diabetes.
Electronic Commerce and the Sociologyof Money (2000)

There is seemingly little
connection between conversations about electronic commerce at an OECD
workshop in San Francisco and talk of ritual cash payments at a Maori
funeral in New Zealand. Yet money is at the centre of both
conversations. There is a hesitant acceptance in regional policy
dialogues that the cultural meanings of money have to be taken into
account before any consensus is possible on issues of electronic
commerce. Recent sociological work on money is also questioning the
duality of the market and society. In the last five years, there has
also been interesting sociological work showing how social relations
and cultural values shape different kinds of market, domestic and
personal monies. It is also revealing the cultural distinctiveness of
the media and forms of transfers. Sociologists of money, particularly
in the United Kingdom, have addressed the management and control of
money in the household and how these relate to social welfare payments.
Sociologists are also addressing the use and non-use of electronic
money in the home, relating it to social inclusion and exclusion.
Policy makers and sociologists of money have areas of common interest.
However, sociologists are mostly absent from this policy debate on
electronic commerce. The challenge for sociologists is to first connect
the new information and communication technologies to changes in the
medium, form, meaning and relationships of money. We can then begin to
forge a language that can address issues of electronic commerce and
culture.
Vortex beams and radiation torque for kidney stone management (2016)

Our team previously developed an instrument to reposition kidney stones with acoustic radiation force. In a clinical trial, the technology was used to transcutaneously facilitate passage of small stones and to relieve pain by dislodging obstructing large stones. Acoustic trapping and manipulation of kidney stones in water has recently been investigated using both single element and sector arrays in the range of 0.3–1.5 MHz. Experimental holographic reconstruction of the transducer surface velocity confirmed the proper operation of each transducer. Human stones approximately 5 mm, as well as glass and aluminum beads, were placed on a flat tissue phantom in a water bath. During exposure, stones were drawn to the beam axis, and then controllably translated along the surface in any direction transverse to the beam. The phase between sector elements could be used to control the vortex size, as well as rate and direction of rotation of the trapped object. The trapping effect was disrupted at increased transducer output, possibly by generation of acoustic streaming. In conclusion, a method was tested for transverse acoustic trapping of kidney stones with vortex beams. [This work was supported by RBBR 14-02-00426, NIH NIDDK DK43881, DK104854, and DK092197, and NSBRI through NASA NCC 9-58.]
Dynamic Monitoring of Ongoing Clinical Trials (2021)

In late 2019, the U.S. FDA updated a new Guidance for Industry on Adaptive Designs for Clinical Trials of Drugs and Biologics. The guideline encourages developing and implementing innovative trial designs for future clinical trials. Group sequential, sample size re-estimation, and adaptive group sequential procedures have been very useful for improving the efficiency of conducting trials for decades. However, they face some challenges in operational aspects which limited their potentials. In this article, we introduce a procedure that addresses these issues. Our proposed procedure has the capability of providing anytime accessibility of the whole up-to-date data history. The procedure is largely built on the proven adaptive group sequential design theories and combined with advanced eClinical technologies in trial management to elevate the trial design and monitoring to a more dynamic level. The construct of a new trial monitoring screen is illustrated with real trial examples. The advantages of anytime accessibility of data and the monitoring a trial with the whole data history and trend are delineated. Data monitoring committees, sponsors and regulatory authorities are important stakeholders in the discussion of how future clinical trials should be monitored with respect to timing and frequency.
Volatile Constituents of<i>Origanum vulgare</i>ssp.<i>viride</i>(syn.<i>O. heracleoticum</i>) from Iran (1997)

Constituents of the volatile oil of Origanum vulgare ssp. viride growing wild in Kodjour (N. Iran) were studied using TLC, GC, GC/MS, and 1H-NMR methods. The oil was composed of monoterpenes and sesquiterpenes. The main components of the monoterpene fraction were linalyl acetate, sabinene, gamma-terpinene, trans-ocimene, and cis-ocimene. Low percentages of the phenolic monoterpenoids (thymol and carvacrol) were detected in the oil. The percentage of the identified sesquiterpenoid components was relatively high (44%). The main components of this fraction were beta-caryophyllene, caryophyllene oxide, germacrene D, and gamma-elemene.
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis (2016)

Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To determine if senescent stromal cells influence tumorigenesis, we develop a mouse model that mimics the aged skin microenvironment. Using this model, here we find that senescent stromal cells are sufficient to drive localized increases in suppressive myeloid cells that contributed to tumour promotion. Further, we find that the stromal-derived senescence-associated secretory phenotype factor interleukin-6 orchestrates both increases in suppressive myeloid cells and their ability to inhibit anti-tumour T-cell responses. Significantly, in aged, cancer-free individuals, we find similar increases in immune cells that also localize near senescent stromal cells. This work provides evidence that the accumulation of senescent stromal cells is sufficient to establish a tumour-permissive, chronic inflammatory microenvironment that can shelter incipient tumour cells, thus allowing them to proliferate and progress unabated by the immune system.
<title>Gradient-index (GRIN) lens multimode fiber probe for laser-induced breakdown in the eye</title> (1994)

A model laser surgical probe was designed and built to employ laser induced breakdown (LIB) in cutting fibrovascular membranes within the vitreous cavity of the eye. The probe is a simple design of a gradient index (GRIN) lens attached to the tip of a multimode fiber. It is designed to fit through a sclerotomy incision and enter the vitreaous cavity for work anterior to the retina. The laser light is focused close to the tip of the probe without causing GRIN lens damage. Thus a widely divergent beam behind the focus will diminish potential laser damage posterior to the target tissue. A Nd:YAG 1064-nm 10-ns pulsed laser was used with the probe inserted into a cell of tap water. Threshold data for laser induced breakdown was taken ad fit to a probit curve. The data was compared with past LIB threshold data. The radiant exposure versus distance from the probe was plotted via spot size measurements. This measurement gave a rough indication of the distance the probe must remain from the retina to be well below retinal maximum permissible exposure (MPE) levels. In-vitro threshold measurements of bovine vitreous were taken and compared to the water threshold. Finally, collagen membranes were lased with the probe to demonstrate its functional application.
Fire Detection by Surface Acoustic Wave Chemical Sensor Systems (1993)

Surface Acoustic Wave (SAW) Chemical Sensor systems have been developed to detect and identify fire threats for shipboard materials. The SAW sensor system is an electronic device that employs an array of SAW devices as a "nose" for chemical vapor detection. Each SAW device in an array is coated with a different polymeric material that selectively absorbs different chemical vapors. Chemical vapors released by thermal decomposition of fire fields (e.g. insulation on electrical cable and thermal insulation foam) provide fingerprint patterns from the sensor array that allow identification of the source material associated with a flaming fire, smoldering fire or the threat of a fire (prior to release of smoke). A neural network routine that was trained with over 500 patterns from fire vapor tests correctly identified the source material for all fire threats tested and distinguished them from possible interference (e.g. AFFF and hydraulic fluid). The SAW sensor system has the potential to give an early warning prior to a flaming fire and, unlike a conventional fire detector in heavy smoke, identify the primary source material in the fire. This information will greatly assist in determining appropriate steps to take in preventing a flaming fire developing from smoldering material, and in taking the proper action in fighting flaming fires. In addition, the SAW sensor system can be used as a multitasking detector searching simultaneously for vapors associated with fires or potential fires, and hazardous chemical vapors from spills, leaks or chemical agent attack. Sensor responses are reversible, so an area exposed to toxic fumes can be monitored in real times as a decontaminating procedure progresses to a safe condition for personnel to enter the area.
An Efficient Synthesis of Valienamine via Ring-Closing Metathesis (2005)

An efficient synthesis of valienamine is described. Valienamine was synthesized starting from commercially available 2,3,4,6-tetra-O-benzyl-D-glucose in nine steps, using ring-closing metathesis of (4S,5S,6S)-4,5,6-tribenzyloxy-7-(benzyloxymethyl)octa-1,7-dien-3-ol as a key step.
Evaluation techniques of metallic biomaterials in vitro (2002)

Metals and alloys are widely used as biomedical materials and are important in medicine and they cannot be replaced with ceramics or polymers at present mainly because of their high strength and toughness. Since safety is the most important property of biomaterials, corrosion-resistant materials such as stainless steel, Co–Cr–Mo alloy, commercially pure titanium, and titanium alloys are employed as biomaterials. Evaluation techniques for corrosion with culturing cells, the characterization of reconstruction of surface oxide film, fretting fatigue, cytotoxicity, and biocompatibility are reviewed in this paper. These techniques are original and characteristics in the field of biomaterials that should contribute to the proper evaluations of biomaterials in vitro.
Squaraine Compounds: Tailored Design and Synthesis towards a Variety of Material Science Applications (2010)

Abstract The interest in squaraine compounds, a relatively old class of dyes, has been recently renewed due to their potential usefulness in a large number of technologically relevant fields such as two‐photon absorbing materials, field‐effect transistors, solar cells, NIR‐emitting fluorescent probes and sensitizers for photodynamic therapy. Aim of the present review is to summarize the most convenient strategies for squaraines and polysquaraines syntheses and to discuss the design strategies enabling for the preparation of squaraines having properties relevant for a given material application. In particular, in the first section of the review we will describe the various synthetic approaches for the preparation of squaraine and polysquaraine derivatives. The second section will focus on squaraines applications. We will describe in detail the use of squaraines in bioimaging and photodynamic therapy. Within the topic of bio‐related applications we will also discuss the applications of squaraines as histological probes. Within the NLO‐related applications, we will focus on squaraine‐based electro‐optic and two‐photon absorbing materials. Dealing with photoconduction related applications, we will discuss the most recent applications of squaraine compounds in various kinds of devices such as solar cells, hybrid solar cells and NIR‐responsive photodetectors. In all of the cases we will mainly focus on structure–property relationships highlighting the role of the active molecule design in the final device performances.
A Novel Clustering Algorithm for Wi-Fi Indoor Positioning (2019)

In recent years, the Wi-Fi-based indoor positioning technology has become a research hotspot. This technology mainly locates the indoor Wi-Fi based on the received signal strength indicator (RSSI) signals. The most popular Wi-Fi positioning algorithm is the k-nearest neighbors (KNN) algorithm. Due to the excessive amount of RSSI data, clustering algorithms are generally adopted to classify the data before KNN positioning. However, the traditional clustering algorithms cannot maintain data integrity after the classification. To solve the problem, this paper puts forward an improved public c-means (IPC) clustering algorithm with high accuracy in indoor environment, and uses the algorithm to optimize the fingerprint database. After being trained in the database, all fingerprint points were divided into several classes. Then, the range of each class was determined by comparing the cluster centers. To optimize the clustering effect, the points in the border area between two classes were allocated to these classes simultaneously, pushing up the positioning accuracy in this area. The experimental results show that the IPC clustering algorithm achieved better accuracy with lighter computing load than FCM clustering and k-means clustering, and could be coupled with KNN or FS-KNN to achieve good positioning effect.
Immunogenic potential of antigens isolated from trypsin pea protein hydrolysates (2008)

The study was undertaken to examine the immunogenic potential of pea protein of Polish cultivar Maraton and its trypsin hydrolysates differing in a degree of hydrolysis. The physicochemical characteristics of a pea protein extract and its hydrolysates, DH 2.0 and 5.0, was conducted by means of SDS-PAGE electrophoresis, chromatofocusing, affinity chromatography, and sequential analysis. The immunogenic properties of pea protein and its trypsin hydrolysates, DH 2.0 and 5.0, were investigated by direct and competitive ELISA methods. The results confirm that the protein extract is a stronger immunogene than the hydrolysates, while hydrolysate with DH 2.0 was a stronger immunogene than that with DH 5.0. The dominant antigen isolated from the pea protein extract and both trypsin hydrolysates had a molecular weight of about 20 kDa and was in glycoprotein fraction. The N-terminal sequence of this antigen was determined to be: Thr-Glu-Thr-Thr-Ser-Phe-Leu-Ile-Thr-Lys. Its precursor is probably pea lectin.