gebhart/patrepeval huggingface dataset:
Second-harmonic generation from a single wurtzite GaAs nanoneedle (2010)

We report and characterize second-harmonic generation from a single wurtzite GaAs nanoneedle. The wurtzite crystal structure of the nanoneedle relaxes the strict nonlinear selection rules of normal zincblende GaAs while maintaining its strong nonlinear optical coefficients. The ability to grow GaAs nanoneedles without catalysts on (111) Si makes them particularly attractive as nonlinear optoelectronic media compatible with complementary metal-oxide-semiconductor technology.
Saliency model based head pose estimation by sparse optical flow (2011)

Head pose plays an important role in Human-Computer interaction, and its estimation is a challenge problem compared to face detection and recognition in computer vision. In this paper, a novel and efficient method is proposed to estimate head pose in real-time video sequences. A saliency model based segmentation method is used not only to extract feature points of face, but also to update and rectify the location of feature points when missing happened. This step also gives a benchmark for vector generation in pose estimation. In subsequent frames feature points will be tracked by sparse optical flow method and head pose can be determined from vectors generated by feature points between successive frames. Via a voting scheme, these vectors with angle and length can give a robust estimation of the head pose. Compared with other methods, annotated training data set and training procedure is not essential in our method. Initialization and re-initialization can be done automatically and are robust for profile head pose. Experimental results show an efficient and robust estimation of the head pose.
Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C (2002)

We examined the effect of fibroblast growth factor (FGF)-2 on myocardial resistance to injury when administered after the onset of ischemia, in vivo and ex vivo, and the role of FGF-2 receptors and protein kinase C (PKC). FGF-2 was injected into the left ventricle of rats undergoing permanent surgical coronary occlusion leading to myocardial infarction (MI). After 24 h, FGF-2-treated hearts displayed significantly reduced injury, determined by histological staining and troponin T release, and improved developed pressure compared with untreated controls. An FGF-2 mutant with diminished affinity for the tyrosine kinase FGF-2 receptor 1 (FGFR1) was not cardioprotective. FGF-2-treated hearts retained improved function and decreased damage at 6 wk after MI. In the ex vivo heart, FGF-2 administration during reperfusion after 30-min ischemia improved functional recovery and increased relative levels of PKC subtypes alpha, epsilon, and zeta in the particulate fraction, in a chelerythrine-preventable mode; it also decreased loss of energy metabolites. We conclude that intramyocardial FGF-2 administration shortly after the onset of ischemia confers protection from acute and chronic cardiac dysfunction and damage; FGF-2 delivered during reperfusion protects from ischemia-reperfusion injury; and protection by FGF-2 requires intact binding to FGFR1 and is likely mediated by PKC.
The Influence of Provider Behavior, Parental Characteristics, and a Public Policy Initiative on the Immunization Status of Children Followed by Private Pediatricians: A Study From Pediatric Research in Office Settings (1997)

Individual provider behavior may be the most important determinant of the immunization status of children followed by private pediatricians. In our samples, the effect of parental characteristics was limited. State-sponsored VVPs were not associated with higher immunization rates, perhaps because cost of vaccines did not seem to be a significant barrier to immunization in this population.
First Phase Insulin Secretion and Type 2 Diabetes (2012)

Type 2 diabetes (T2D) is a metabolic disorder characterised by the inability of β-cells to secrete enough insulin to maintain glucose homeostasis. Pancreatic β-cells secrete insulin in a biphasic manner, first and second phase insulin secretion, and loss of first phase insulin secretion is an independent predictor of T2D onset. Restoration of first phase insulin secretion has been shown to improve blood glucose in T2D by suppressing hepatic glucose production and priming insulin sensitive tissue to more readily take up glucose and has thus prompted numerous studies into its regulation. First phase insulin secretion is initiated primarily by the classical triggering pathway, a complex system comprised of multiple stimulatory signals. Recent studies have identified a number of novel regulatory factors that are crucial for first phase insulin secretion and glucose homeostasis. These include, among others, hypoxia inducible factor 1α, von Hippel-Lindau, factor inhibiting HIF, nicotinamide phospho-ribosyl-transferase, and the sirtuin family. This review will outline how first phase insulin secretion is initiated and detail some of the recent findings in its regulation.
Towards Practical ABox Abduction in Large Description Logic Ontologies (2012)

ABox abduction is an important reasoning facility in Description Logics (DLs). It finds all minimal sets of ABox axioms, called abductive solutions, which should be added to a background ontology to enforce entailment of an observation which is a specified set of ABox axioms. However, ABox abduction is far from practical by now because there lack feasible methods working in finite time for expressive DLs. To pave a way to practical ABox abduction, this paper proposes a new problem for ABox abduction and a new method for computing abductive solutions accordingly. The proposed problem guarantees finite number of abductive solutions. The proposed method works in finite time for a very expressive DL, , which underpins the W3C standard language OWL 2, and guarantees soundness and conditional completeness of computed results. Experimental results on benchmark ontologies show that the method is feasible and can scale to large ABoxes.
Field deployment and evaluation of 1510 nm data communication network for MONET Washington DC network trial (2003)

We report on the design and field performance evaluation of an embedded, out-of-band, 1510-nm data communication network (DCN) at OC-3c data rate for the eight-wavelength, reconfigurable MONET washington D.C. testbed. The results of this field trial demonstrate that a multinode control and management system can depend on such a highly reliable DCN.
Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions (2013)

The antiviral activity of KR13 and its ability to inactivate virions prior to target cell engagement suggest that peptide triazole thiols could be highly effective in inhibiting HIV transmission across mucosal barriers and provide a novel probe to understand biochemical signals within envelope that are involved in membrane fusion.
Deep-AmPEP30: Improve Short Antimicrobial Peptides Prediction with Deep Learning (2020)

Antimicrobial peptides (AMPs) are a valuable source of antimicrobial agents and a potential solution to the multi-drug resistance problem. In particular, short-length AMPs have been shown to have enhanced antimicrobial activities, higher stability, and lower toxicity to human cells. We present a short-length (≤30 aa) AMP prediction method, Deep-AmPEP30, developed based on an optimal feature set of PseKRAAC reduced amino acids composition and convolutional neural network. On a balanced benchmark dataset of 188 samples, Deep-AmPEP30 yields an improved performance of 77% in accuracy, 85% in the area under the receiver operating characteristic curve (AUC-ROC), and 85% in area under the precision-recall curve (AUC-PR) over existing machine learning-based methods. To demonstrate its power, we screened the genome sequence of Candida glabrata-a gut commensal fungus expected to interact with and/or inhibit other microbes in the gut-for potential AMPs and identified a peptide of 20 aa (P3, FWELWKFLKSLWSIFPRRRP) with strong anti-bacteria activity against Bacillus subtilis and Vibrio parahaemolyticus. The potency of the peptide is remarkably comparable to that of ampicillin. Therefore, Deep-AmPEP30 is a promising prediction tool to identify short-length AMPs from genomic sequences for drug discovery. Our method is available at https://cbbio.cis.um.edu.mo/AxPEP for both individual sequence prediction and genome screening for AMPs.
Preparation and characterization of atomically clean, stoichiometric surfaces of AIN(0001) (2004)

In situ exposure of the (0001) surface of AlN thin films to flowing ammonia at 1120 °C and 10−4Torr removes oxygen∕hydroxide and hydrocarbon species below the detectable limits of x-ray photoelectron spectroscopy and decreases the Al∕N ratio from 1.3 to 1.0. The positions of the Al2p and the N1s core level peaks acquired from the cleaned surfaces were 75.0±0.1eV and 398.2±0.1eV, respectively, which were similar to the values determined for the as-loaded samples. The cleaning process left unchanged the (1×1) low energy electron diffraction pattern, the step-and-terrace microstructure, and the root mean square roughness values observed for the surfaces of the as-loaded samples; i.e., the surface structure and microstructure were not changed by the high-temperature exposure to ammonia at low pressures. Vacuum annealing under 10−7Torr at 1175 °C for 15 min removed all detectable hydrocarbons; however, it did not remove the oxygen∕hydroxide species.
Thin Film Permeability Evaluation Based on Skin Effect Using Meander-Type Probe Up to 10.6 GHz (2011)

A highly sensitive and broadband method of obtaining thin film permeability without limitations in sample size was developed based on the high-frequency impedance change because of skin effect. A meander-type probe (3.5 mm <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\,\times\,$</tex></formula> 2.5 mm, 2 turns) was placed in proximity of a (Co <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$_{25}$</tex></formula> Fe <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$_{75}$</tex></formula> ) <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$_{90}$</tex></formula> B <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$_{10}$</tex></formula> film (45 mm <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$\,\times\,$</tex></formula> 25 mm, 0.53 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$\mu$</tex></formula> m thick), and the permeability was optimized by Newton–Raphson method. The measured values are in good agreements with theoretical values based on the Landau–Lifshitz–Gilbert equation up to 10.6 GHz. The proposed method shows promise for measuring the permeability of wafer-sized samples in line because it is not restricted by size limitations.
tRNAMetf2 gene in the leader region of the nusA operon in Escherichia coli. (1984)

The promoter-proximal portion of the operon containing the Escherichia coli nusA gene has been cloned. Its nucleotide sequence shows that genes for tRNAMetf2 and a 15-kilodalton protein of unknown function precede the nusA protein gene. The sequence suggests that the three genes form a single transcription unit. Consistent with this hypothesis, purified RNA polymerase formed full-length transcripts on the cloned DNA in vitro, although transcription was frequently arrested at the intercistronic site(s) between the gene for tRNAMetf2 and the 15-kilodalton protein.
Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas. (1999)

Because programmed cell death (PCD) is an important mode of pericyte dropout in human diabetic retinopathy, whether increased oxidative stress in cells with diminished antioxidant defenses plays a causative role in the PCD process in diabetic pericytes has been studied. Ten diabetic and eight non-diabetic eye-bank eyes from 5 diabetic and 4 non-diabetic patients were included in this study. From individual neural retinas pericytes were isolated by a newly developed immunomagnetic technique. Total mRNA of the purified pericytes was isolated for quantitative reverse transcriptase (RT)-PCR assay. mRNA levels of a death protease (CPP32), the major enzyme that initiates the proteolytic cascade leading to cell death, were determined in association with the expression of antioxidative enzymes including glutathione peroxidase (GSH-Px), glutathione reductase, CuZn superoxide dismutase (SOD), MnSOD and catalase genes in pericytes. In comparison with pericytes from non-diabetic retinas, pericytes from diabetic retinas highly expressed CPP32 genes (4 +/- 0.6 fold increase, p < 0.01, n = 9). In diabetic pericytes, up-regulation of glutathione peroxidase (GSH-Px) (8.2 +/- 0.9 fold increase, p < 0.01, n = 9) and down-regulation of glutathione reductase (Gr) (4.1 +/- 0.4 fold decrease, p < 0.05, n = 9) and CuZnSOD (2.1 +/- 0.7 fold decrease, p < 0.05, n = 9) were observed. mRNA levels of MnSOD and catalase of diabetic pericytes did not differ significantly from those of non-diabetic pericytes. Overexpression of a member of interleukin-1 beta-converting enzyme (ICE) family, CPP32, indicated that the pericytes from diabetic retinas are in a "pre-PCD" state. This is the first evidence that the ICE family of death proteases is involved in pericyte dropout in diabetes. In these pre-PCD cells, the expression of antioxidant enzyme genes also was changed. Up-regulation of GSH-Px indicates a compensation mechanism to meet the demand of excessive glutathione in reduced form. Decreased levels of both glutathione reductase and CuZnSOD, despite the oxidative stress in the diabetic condition, suggest the breakdown of the antioxidant defense in pericytes. Most importantly, the altered gene profile of scavenging enzymes under diabetic conditions, correlating with overexpression of the cell death protease gene, together suggest increased oxidative stress as an etiological agent of pericyte dropout in diabetic retinopathy.
54.4: Adaptive Dual Pulse Backlight for LCD‐TV displays (2006)

Abstract Due to the sample & hold nature of AM‐LCD panels, display systems using these panels will suffer from motion portrayal artifacts. As TV applications require proper motion portrayal, overdrive and impulse driving are both required. This paper describes a scanning and dimming backlight system, which is extended with an Adaptive Dual Pulse Backlight technology to reduce image flicker.
Uteroglobin Represses Allergen-induced Inflammatory Response by Blocking PGD2 Receptor–mediated Functions (2004)

Uteroglobin (UG) is an antiinflammatory protein secreted by the epithelial lining of all organs communicating with the external environment. We reported previously that UG-knockout mice manifest exaggerated inflammatory response to allergen, characterized by increased eotaxin and Th2 cytokine gene expression, and eosinophil infiltration in the lungs. In this study, we uncovered that the airway epithelia of these mice also express high levels of cyclooxygenase (COX)-2, a key enzyme for the production of proinflammatory lipid mediators, and the bronchoalveolar lavage fluid (BALF) contain elevated levels of prostaglandin D2. These effects are abrogated by recombinant UG treatment. Although it has been reported that prostaglandin D2 mediates allergic inflammation via its receptor, DP, neither the molecular mechanism(s) of DP signaling nor the mechanism by which UG suppresses DP-mediated inflammatory response are clearly understood. Here we report that DP signaling is mediated via p38 mitogen-activated protein kinase, p44/42 mitogen-activated protein kinase, and protein kinase C pathways in a cell type-specific manner leading to nuclear factor-kappaB activation stimulating COX-2 gene expression. Further, we found that recombinant UG blocks DP-mediated nuclear factor-kappaB activation and suppresses COX-2 gene expression. We propose that UG is an essential component of a novel innate homeostatic mechanism in the mammalian airways to repress allergen-induced inflammatory responses.
Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods (2018)

The concept that abnormal protein aggregates show prion-like propagation between cells has been considered to explain the onset and progression of many neurodegenerative diseases. Indeed, both synthetic amyloid-like fibrils and pathogenic proteins extracted from patients' brains induce self-templated amplification and cell-to-cell transmission in vitro and in vivo. However, it is unclear whether exposure to exogenous prion-like proteins can potentially cause these diseases in humans. Here, we investigated in detail the prion-like seeding activities of several kinds of pathogenic α-synuclein (α-syn), including synthetic fibrils and detergent-insoluble fractions extracted from brains of patients with α-synucleinopathies. Exposure to synthetic α-syn fibrils at concentrations above 100 pg/mL caused seeded aggregation of α-syn in SH-SY5Y cells, and seeded aggregation was also observed in C57BL/6 J mice after intracerebral inoculation of at least 0.1 μg/animal. α-Syn aggregates extracted from brains of multiple system atrophy (MSA) patients showed higher seeding activity than those extracted from patients with dementia with Lewy bodies (DLB), and their potency was similar to that of synthetic α-syn fibrils. We also examined the effects of various methods that have been reported to inactivate abnormal prion proteins (PrP<sup>Sc</sup>), including autoclaving at various temperatures, exposure to sodium dodecyl sulfate (SDS), and combined treatments. The combination of autoclaving and 1% SDS substantially reduced the seeding activities of synthetic α-syn fibrils and α-syn aggregates extracted from MSA brains. However, single treatment with 1% SDS or generally used sterilization conditions proved insufficient to prevent accumulation of pathological α-syn. In conclusion, α-syn aggregates derived from MSA patients showed a potent prion-like seeding activity, which could be efficiently reduced by combined use of SDS and autoclaving.
Substrate bonding using electroplated copper through silicon vias for VCSEL fabrication (2014)

We present a novel approach to bound any substrate on a silicon host platform, in the particular case of the realization of InP based vertical cavity surface emitting lasers (VCSEL). This process is based on a mechanical bonding, using electroplated copper through silicon vias. It enables a cost effective bonding with a low induced stress, and a significant improvement of the device thermal properties. Preliminary results are presented on the realization of light emitting diodes.
Jablesses, Sourcriants, Loups‐garous: Obeah as an alternative epistemology in the writing of Jean Rhys and Jamaica Kincaid (1997)

(1997). Jablesses, Sourcriants, Loups‐garous: Obeah as an alternative epistemology in the writing of Jean Rhys and Jamaica Kincaid. World Literature Written in English: Vol. 36, No. 1, pp. 3-29.
Nitric Oxide and Reactive Oxygen Species in Parkinson's Disease (2003)

Parkinson's disease is a neurodegenerative disorder of unknown pathogenesis. Oxidative stress has been proposed as one of several pathogenic hypotheses. Evidence for the participation of oxidative processes in the pathogenesis of Parkinson's disease have been obtained in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model by the use of genetically altered mice. MPTP administration has been shown to increase levels of superoxide both intracellularly, via the inhibition of mitochondrial respiration and other mechanisms and extracellularly, via the activation of NADPH-oxidase in microglia. In addition to superoxide, nitric oxide production by nNOS or by microglial iNOS also contributes to the MPTP neurotoxocity. Mice with endowed defences against superoxide or with deficiency in the nNOS and iNOS are protected from MPTP toxicity suggesting that formation of reactive oxygen and nitrogen intermediates both intracellularly and extracellularly contributes to the demise of dopaminergic neurons. Similar contribution of reactive nitrogen and oxygen species may well underlie the neurodegenerative processes in Parkinson's disease.
Synthesis, Evaluation and Preliminary Antibacterial Testing of Hybrid Composites Based on Urethane Oligodimethacrylates and Ag Nanoparticles (2012)

A series of urethane dimethacrylates differing structurally by the nature of the spacer (PTHF, PCL, PEG) and the presence or absence of the carboxylic acid groups was synthesized via an isocyanate route frequently encountered in ionomer chemistry. (1)H-NMR and FT-IR spectroscopy confirmed the structure of the macromers. Subsequently, the progress of photo-polymerization of all dimethacrylates under UV irradiation was investigated by FT-IR spectroscopy and photo-DSC with respect to conversion and polymerization rate using Irgacure as an initiator. The results of spectroscopic analysis suggested the lower reactivity of some non-carboxylic analogues during the formation of cross-linked polymers, the degree of conversion depending on the structure and viscosity. Photo-polymerization may provide many advantages for incorporating silver nanoparticles (2.5 wt%) into macromers in order to obtain hybrid nanocomposite films with controllable thickness and hydrophobicity. Combined analyses of UV spectroscopy and transmission electron microscopy confirmed the existence of nanosized silver (mean diameter 12 ± 0.7 nm) uniformly distributed in the polymer matrix. Preliminary results concerning the antibacterial activity of some composite films (thickness approx. 24 μm) showed that the obtained nanomaterial could have an excellent bactericidal effect and effectiveness in reducing bacterial growth (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923).
Metal–organic framework MIL-101 as a low background signal platform for label-free DNA detection (2013)

A label-free and sensitive fluorescence method for recognition of sequence-specific DNA using DNA-intercalating dye and metal-organic frameworks (MOFs) is developed. Here, MIL-101 (Cr3F(H2O)2O[(O2C)-C6H4-(CO2)]3·nH2O) is introduced as a quenching platform to decrease the high background fluorescence of SYBR Green I (SG)/probe DNA complex. Mechanism investigations show that MIL-101 can strongly adsorb the SG/probe DNA complex through π-π stacking and electrostatic interactions, and as a consequence, the fluorescence of the SG dye is greatly quenched. While in the presence of target DNA, the as-formed rigid double-stranded (ds) structure of DNA will be far away from the surface of MIL-101; meanwhile, the SG dye can be bound with the dsDNA in the mode of intercalation and minor groove binding, resulting in enhancement of the SG dye fluorescence. The increased signal-to-background ratio has a linear relationship with the concentration of target DNA in the range of 0.1-14 nM. It is confirmed that the detection limit is 73 pM (3σ), which is much lower than that based on the carbon nanotubes and graphene oxide platform. Moreover, one-base-mismatched target DNA can be discriminated effectively. With the introduction of MIL-101, the signal-to-background ratio has been improved ∼8-fold, demonstrating that MIL-101 is an efficient low-background signal platform.