gebhart/patrepeval huggingface dataset:
Protección al medio ambiente y solución de controversias en materia de inversiones en el TLCAN (2004)

The need to adhere to a com- petitive plan in the struggle to attract direct foreign investment and, at the same time, to preserve the direction of the strategic areas of the economy, we- re the two salient elements of the nego- tiating strategy of the Mexican Govern- ment in the investment chapter in the TLCAN. The practice developed during ten years of experience, has manifested salient connections between the environ- ment and the resolution of controversies in the subject of foreign investment, which makes it necessary to now review what cases have been posed and the de- cisions made on the subject.
Synthesis of Group 6 metal carbonyls with hybrid P-donor crown ether and aza-crown ether ligands and the effect of phosphorus substituents on their reaction with RLi reagents (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Group 6 metal carbonyls with hybrid P-donor crown ether and aza-crown ether ligands and the effect of phosphorus substituents on their reaction with RLi reagentsJohn. Powell, Anda. Kuksis, Christopher J. May, Patricia E. Meindl, and Stuart J. SmithCite this: Organometallics 1989, 8, 12, 2933–2941Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/om00114a030https://doi.org/10.1021/om00114a030research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Endocrine hypertension: An overview on the current etiopathogenesis and management options (2015)

Endocrine causes of secondary hypertension include primary aldosteronism, pheochromocytoma, cushing's syndrome, hyperparathyroidism and hypo- and hyperthyroidism. They comprise of the 5%-10% of the causes of secondary hypertension. Primary hyperaldosteronism, the most common of the endocrine cause of hypertension often presents with resistant or difficult to control hypertension associated with either normo-or hypokalemia. Pheochromocytoma, the great mimicker of many conditions, is associated with high morbidity and mortality if left untreated. A complete history including pertinent family history, physical examination along with a high index of suspicion with focused biochemical and radiological evaluation is important to diagnose and effectively treat these conditions. The cost effective targeted genetic screening for current known mutations associated with pheochromocytoma are important for early diagnosis and management in family members. The current review focuses on the most recent evidence regarding causes, clinical features, methods of diagnosis, and management of these conditions. A multidisciplinary approach involving internists, endocrinologists and surgeons is recommended in optimal management of these conditions.
The Role of Colloidal Stability and Charge in Functionalization of Aqueous Quantum Dots (2018)

Semiconductor quantum dots (QDs), also known as nanocrystals, have unique photophysical properties that have allowed them to find utility in many applications, including television and display technologies. They also have significant potential as imaging agents in the biomedical field. To gain the most value from the use of QDs as health-related fluorescent probes, they must be biologically targetable and sensitive to metabolic analytes such as pH and O<sub>2</sub>, and the resulting signal must be quantifiable. To achieve these goals, QDs need to be conjugated to vectors such as antibodies or environmentally sensitive chromophores. Until recently, the functionalization of these nanomaterials required a complex fully "bottom-up" approach beginning with the synthesis of the QDs and subsequent manipulations. To simplify this process, our group set out to develop straightforward methods to prepare functionalized nanomaterials for biological imaging and sensing using low-cost, commercially available aqueous QD dispersions. In this Account, we review the common problems and likely solutions related to functionalization of QDs in water with chemical and biological vectors. Early in our investigations, we found that established protocols using a commercially available activating reagent resulted in either low reaction yields or QD precipitation. This was a consequence of the perturbation of the QDs' surface charges by the activating reagent and the conjugation substrate. These surface charges are derived from the anionic surfactants that are commonly employed for encapsulating water-soluble nanomaterials. Thus, cancellation of the surface charges by reagents or substrates results in colloidal instability. To address this problem, we devised conjugation methods that do not alter the overall charge balance of the system. Incorporating reactive moieties directly into the QD's water-solubilizing polymer encapsulants negates the need for destabilizing activators, allowing for functionalization of aqueous samples without precipitation. The most successful approach was realized using neutral activating reagents, such as poly(ethylene glycol) carbodiimide (PEG-CD). PEG-CD binds to the carboxylic acid coating of water-soluble QDs, which primes them for amide bond formation with amine-functionalized substrates. Most importantly, this method can be applied to commercially available aqueous QDs. Using this method, we achieved reaction yields as high as 95%, allowing us to demonstrate a wide-range of QD functionalities and applications for chemical and biological sensing. Conjugation of environmentally sensitive dyes to water-soluble QDs results in reversible and ratiometrically reporting fluorescent probes for metabolic analytes such as pH, bisulfide, and O<sub>2</sub>. QDs can also be functionalized with proteins for passive cell delivery or coated with poly(ethylene glycol) to enhance biocompatibility for in vivo studies. In the future, these capabilities may be combined to realize the full potential of quantum dot nanotechnology for biological discovery.
Next-Generation Sequencing (2016)

Next-generation sequencing (NGS), otherwise known as deep or massively parallel sequencing, refers to the technological advances in DNA sequencing instrumentation that enable the generation of hundreds of thousands to millions of sequence reads per run. Sequencing of the human genome, which was once a >10-year endeavor by the NIH at the cost of approximately $3 billion (1), can now be done routinely on a single instrument. Rapid advances in technology led to the first-ever FDA clearance of an NGS instrument, the Illumina MiSeq, in 2014 (2), and the development of rapid, miniaturized sequencing devices such as the Oxford Nanopore are ongoing (3). The applications of NGS are wide-ranging and include (i) whole-genome sequencing, (ii) pathogen discovery, (iii) metagenomic/microbiome analyses, (iv) transcriptome profiling, and (vi) infectious disease diagnosis. Here we will focus on NGS technology and the last three applications, because the first two topics are described in detail elsewhere.
Demystifying acid-base regulation. (1998)

Acid-base imbalances may have serious clinical implications for all patients. The maintenance of homeostasis within the body is intimately linked to the balance of acids and bases within the body. Any disturbance in this balance will adversely effect all cellular metabolism and ultimately the functioning of vital body systems. Figure 3 may help you to understand the integration of the mechanisms which regulate acid-base balance in the body.
Microwave and RF Circuits: Analysis, Synthesis, and Design (1992)

Network characterization network analysis mapping and optimization modern network synthesis distributed network synthesis impedance-matching and modeling practical applications.
Muscle ring finger protein-1 inhibits PKCε activation and prevents cardiomyocyte hypertrophy (2004)

Much effort has focused on characterizing the signal transduction cascades that are associated with cardiac hypertrophy. In spite of this, we still know little about the mechanisms that inhibit hypertrophic growth. We define a novel anti-hypertrophic signaling pathway regulated by muscle ring finger protein-1 (MURF1) that inhibits the agonist-stimulated PKC-mediated signaling response in neonatal rat ventricular myocytes. MURF1 interacts with receptor for activated protein kinase C (RACK1) and colocalizes with RACK1 after activation with phenylephrine or PMA. Coincident with this agonist-stimulated interaction, MURF1 blocks PKCepsilon translocation to focal adhesions, which is a critical event in the hypertrophic signaling cascade. MURF1 inhibits focal adhesion formation, and the activity of downstream effector ERK1/2 is also inhibited in the presence of MURF1. MURF1 inhibits phenylephrine-induced (but not IGF-1-induced) increases in cell size. These findings establish that MURF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy.
Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic <i>op/op</i> mice (2012)

Osteoclasts are generated from monocyte/macrophage-lineage precursors in response to colony-stimulating factor 1 (CSF-1) and receptor activator of nuclear factor-κB ligand (RANKL). CSF-1-mutated CSF-1(op/op) mice as well as RANKL(-/-) mice exhibit osteopetrosis (OP) caused by osteoclast deficiency. We previously identified RANKL receptor (RANK)/CSF-1 receptor (CSF-1R) double-positive cells as osteoclast precursors (OCPs), which existed in bone in RANKL(-/-) mice. Here we show that OCPs do not exist in bone but in spleen in CSF-1(op/op) mice, and spleen acts as their reservoir. IL-34, a newly discovered CSF-1R ligand, was highly expressed in vascular endothelial cells in spleen in CSF-1(op/op) mice. Vascular endothelial cells in bone also expressed IL-34, but its expression level was much lower than in spleen, suggesting a role of IL-34 in the splenic generation of OCPs. Splenectomy (SPX) blocked CSF-1-induced osteoclastogenesis in CSF-1(op/op) mice. Osteoclasts appeared in aged CSF-1(op/op) mice with up-regulation of IL-34 expression in spleen and bone. Splenectomy blocked the age-associated appearance of osteoclasts. The injection of 2-methylene-19-nor-(20S)-1α,25(OH)(2)D(3) (2MD), a potent analog of 1α,25-dihidroxyvitamin D(3), into CSF-1(op/op) mice induced both hypercalcemia and osteoclastogenesis. Administration of 2MD enhanced IL-34 expression not only in spleen but also in bone through a vitamin D receptor-mediated mechanism. Either splenectomy or siRNA-mediated knockdown of IL-34 suppressed 2MD-induced osteoclastogenesis. These results suggest that IL-34 plays a pivotal role in maintaining the splenic reservoir of OCPs, which are transferred to bone in response to diverse stimuli, in CSF-1(op/op) mice. The present study also suggests that the IL-34 gene in vascular endothelial cells is a unique target of vitamin D.
A Prospective, Randomized Comparison of three different types of Valved and Non-Valved Peripherally inserted Central Catheters (2014)

We found no clinical advantages of valved vs. non-valved PICCs.
Experimental Study of Pulsed Discharge Underwater Shock‐Related Properties in Pressurized Liquid Water (2018)

Engineering background of hydraulic fracturing is applied to improve the permeability of unconventional gas wells, such as coal seams and shale gas wells, by a pulsed discharge mechanism. We studied the general relations between water shock wave properties (the maximum pressure, wave velocity, and energy conversion efficiency), the discharge voltage, and hydrostatic pressure during high‐voltage pulsed discharge experiments in pressurized liquid water. The following observations were made: (1) when the discharge voltage increased from 7 kV to 13 kV, the maximum pressure increased from 12.6 MPa (hydrostatic pressure P H = 12 MPa) to 40 MPa ( P H = 6 MPa), wave velocity increased from 1418 m/s ( P H = 12 MPa) to 1454 m/s ( P H = 6 MPa), and energy conversion efficiency increased from 9% to 11%, and (2) when hydrostatic pressure increased from 0 MPa to 12 MPa, the maximum pressure and wave velocity augmented and then diminished slowly (the critical hydrostatic pressure occurs in the 3 to 6 MPa range), whereas the change of energy conversion efficiency was not obvious. Their properties are explained by the variation of electrical parameters during the pulsed discharge.
Needle path planning for digital breast tomosynthesis biopsy (2010)

This paper presents a new needle path planning method for digital breast tomosynthesis biopsy. Needle insertion planning into deformable tissue for breast biopsy procedure is a challenging task because of the infinite possibilities of insertion points. In addition, the lesion moves from its original position when the radiologist introduces the biopsy needle. The proposed approach couples Rapidly-exploring Random Trees with Finite Element Simulation in order to find an optimal path taking breast deformations into account. Simulation results show that this method reduces the error (i.e. the distance between the needle tip and the lesion) by 80%.
Self-Assembled Core–Shell Nanoparticles for Combined Chemotherapy and Photodynamic Therapy of Resistant Head and Neck Cancers (2015)

Combination therapy enhances anticancer efficacy of both drugs via synergistic effects. We report here nanoscale coordination polymer (NCP)-based core-shell nanoparticles carrying high payloads of cisplatin and the photosensitizer pyrolipid, NCP@pyrolipid, for combined chemotherapy and photodynamic therapy (PDT). NCP@pyrolipid releases cisplatin and pyrolipid in a triggered manner to synergistically induce cancer cell apoptosis and necrosis. In vivo pharmacokinetic and biodistribution studies in mice show prolonged blood circulation times, low uptake in normal organs, and high tumor accumulation of cisplatin and pyrolipid. Compared to monotherapy, NCP@pyrolipid shows superior potency and efficacy in tumor regression (83% reduction in tumor volume) at low drug doses in the cisplatin-resistant human head and neck cancer SQ20B xenograft murine model. We elucidated the in vitro/vivo fate of the lipid layer and its implications on the mechanisms of actions. This study suggests multifunctional NCP core-shell nanoparticles as a versatile and effective drug delivery system for potential translation to the clinic.
Using Gpu For Fast Block-Matching (2006)

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 2006
Acute Kidney Injury: Gateway to Chronic Kidney Disease (2014)

This review examines the evidence linking acute kidney injury (AKI) with the risk of subsequently developing chronic kidney disease (CKD). The discussion focuses on subjects that recover from an episode of AKI, most of whom do not receive follow-up nephrology care. Many recent studies have shown a strong association between AKI and the risk of developing CKD. Preclinical models provide evidence for a causal link between AKI and CKD while also proposing some of the potential mechanisms for this progression. Large observational studies have begun to quantify the risk for CKD following AKI recovery and identify risk factors for the development of CKD. In summary, there is an association between AKI with incomplete recovery or lack of recovery and CKD. Multiple studies now suggest that even AKI with apparent full recovery confers an independent risk for later development of CKD. Severity of AKI, baseline CKD, and multiple episodes of AKI remain consistent risk factors for CKD after AKI. The proposed risk prediction models that have been developed require further refinement and validation. The identification of patients with AKI recovery who are at high risk for later CKD development remains an important clinical and research goal.
Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice (2022)

Targeting the aryl hydrocarbon receptor (AhR) is an emerging therapeutic strategy for multiple diseases (e.g., inflammatory bowel disease). <i>Thermosporothrix hazakensis</i> microbial metabolite 2-(1'<i>H</i>-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) is a putative AhR endogenous ligand. To improve the chemical stability, we synthesized a series of ITE chemical mimics. Using a series of in vitro assays, we identified 2-(1<i>H</i>-indole-3-carbonyl)-<i>N</i>-methyl thiazole-4-carboxamide (ITE-CONHCH<sub>3</sub>) as a highly potent (EC<sub>50</sub> = 1.6 nM) AhR agonist with high affinity (<i>K</i><sub>i</sub> = 88 nM). ITE-CONHCH<sub>3</sub> triggered AhR nuclear translocation and dimerization of AhR-ARNT, enhanced AhR binding in the CYP1A1 promoter, and induced AhR-regulated genes in an AhR-dependent manner. The metabolic stability of ITE-CONHCH<sub>3</sub> in a cell culture was 10 times higher than that of ITE. Finally, we observed protective effects of ITE-CONHCH<sub>3</sub> in mice with DSS-induced colitis. Overall, we demonstrate and validate a concept of microbial metabolite mimicry in the therapeutic targeting of AhR.
A role for caleosin in degradation of oil‐body storage lipid during seed germination (2006)

Caleosin is a Ca(2+)-binding oil-body surface protein. To assess its role in the degradation of oil-bodies, two independent insertion mutants lacking caleosin were studied. Both mutants demonstrated significant delay of breakdown of the 20:1 storage lipid at 48 and 60 h of germination. Additionally, although germination rates for seeds were not affected by the mutations, mutant seedlings grew more slowly than wild type when measured at 48 h of germination, a defect that was corrected with continued growth for 72 and 96 h in the light. After 48 h of germination, wild-type central vacuoles had smooth contours and demonstrated internalization of oil bodies and of membrane containing alpha- and delta-tonoplast intrinsic proteins (TIPs), markers for protein storage vacuoles. In contrast, mutant central vacuoles had distorted limiting membranes displaying domains with clumps of the two TIPs, and they contained fewer oil bodies. Thus, during germination caleosin plays a role in the degradation of storage lipid in oil bodies. Its role involves both the normal modification of storage vacuole membrane and the interaction of oil bodies with vacuoles. The results indicate that interaction of oil bodies with vacuoles is one mechanism that contributes to the degradation of storage lipid.
<title>A Technique For Effectively Measuring MTF Of Image Intensifiers At Low Output Levels</title> (1974)

A unique instrumentation technique has been developed by industry and is in regular application at the Night Vision Laboratory to repeatably measure the modulation transfer function of image intensifiers operating at output light levels well below that visible. Two of the most severe problems associated with such measurements, very poor signal-to-noise ratio and difficulty of normalization, have been overcome while maintaining an instrument that may be set up, adjusted, and operated quickly by personnel with a skill level comparable to that needed for routine MTF measurements of lenses at high light levels. These advances were made possible by the inclusion of a digital signal averager, a unique film pattern, and innovative electronic interfacing and analization circuitry. Both the fundamental instrumentation concept and the details of how the practical instrument was realized are discussed in this paper.
ESE‐1 is a potent repressor of type II collagen gene ( <i>COL2A1</i> ) transcription in human chondrocytes (2007)

The epithelium-specific ETS (ESE)-1 transcription factor is induced in chondrocytes by interleukin-1beta (IL-1beta). We reported previously that early activation of EGR-1 by IL-1beta results in suppression of the proximal COL2A1 promoter activity by displacement of Sp1 from GC boxes. Here we report that ESE-1 is a potent transcriptional suppressor of COL2A1 promoter activity in chondrocytes and accounts for the sustained, NF-kappaB-dependent inhibition by IL-1beta. Of the ETS factors tested, this response was specific to ESE-1, since ESE-3, which was also induced by IL-1beta, suppressed COL2A1 promoter activity only weakly. In contrast, overexpression of ETS-1 increased COL2A1 promoter activity and blocked the inhibition by IL-1beta. These responses to ESE-1 and ETS-1 were confirmed using siRNA-ESE1 and siRNA-ETS1. In transient cotransfections, the inhibitory responses to ESE-1 and IL-1beta colocalized in the -577/-132 bp promoter region, ESE-1 bound specifically to tandem ETS sites at -403/-381 bp, and IL-1-induced binding of ESE-1 to the COL2A1 promoter was confirmed in vivo by ChIP. Our results indicate that ESE-1 serves a potent repressor function by interacting with at least two sites in the COL2A1 promoter. However, the endogenous response may depend upon the balance of other ETS factors such as ETS-1, and other IL-1-induced factors, including EGR-1 at any given time. Intracellular ESE-1 staining in chondrocytes in cartilage from patients with osteoarthritis (OA), but not in normal cartilage, further suggests a fundamental role for ESE-1 in cartilage degeneration and suppression of repair.
Remote Control of Catalytic Sites by Spillover Species: A Chemical Reaction Engineering Approach∗ (1996)

Introduction Evidence has accumulated in the last 20 years that spillover processes play a crucial role in many catalytic phenomena. Four symposia have highlighted the advances of knowledge in this area, and the progressive recognition that the phenomena have extremely important consequences (Delmon et al., 1973; Inui et al., 1993; Pajonk et al., 1983; Steinberg, 1989). In spite of this, very few kinetic models incorporating spillover have been presented. Little attention, if any, is given to these phenomena in the design of processes or in the definition of operating conditions.