gebhart/patrepeval huggingface dataset:
Phase steering for modified dodecahedral array for mobile satcoms (1998)

Satellite communication to a mobile unit such as a Landrover, which may be moving over quite rough terrain, represents a challenge to the antenna designer. The signal has to be received over the full upper hemisphere, with allowance for the fact that the antenna platform may be tilted at any time by up to 20 u in any direction. The signal should be received with much the same strength whatever the orientation, and also a substantial antenna gain (of the order of 20 dB) is also desirable, at a carrier frequency of about 8 GHz. A spherical array antenna seems a good starting point for the design, though not quite the whole sphere would be needed, but this would not lend itself conveniently to an advantage that planar arrays, for example, have of allowing modular design, including the use of printed circuit technology. This permits a useful number of elements to be combined on a module (or tile) reducing the array cost substantially. A close approximation to a sphere is given by the regular solids of the icosahedron (20 triangular faces) or the dodecahedron (12 pentagonal faces). The full array would then consist of 60 identical triangles each carrying six elements, but in fact the lowest faces are not required and only 40 are used. We consider how the relative phase of the signal at each element can be determined systematically for this relatively complex array, in order to steer it, for transmission or reception. The link uses circular polarization, and this is a further complication in the steering phase computation. (6 pages)
Direct coupling of a liquid chromatograph to a continuous flow hydrogen nuclear magnetic resonance detector for analysis of petroleum and synthetic fuels (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect coupling of a liquid chromatograph to a continuous flow hydrogen nuclear magnetic resonance detector for analysis of petroleum and synthetic fuelsJames F. Haw, T. E. Glass, D. W. Hausler, Edwin. Motell, and H. C. DornCite this: Anal. Chem. 1980, 52, 7, 1135–1140Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/ac50057a032https://doi.org/10.1021/ac50057a032research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
THE CALCIUM ANTAGONISTIC EFFECTS OF CYPROHEPTADINE ON CONTRACTION, MEMBRANE ELECTRICAL EVENTS AND CALCIUM INFLUX IN THE GUINEA‐PIG TAENIA COLI (1981)

1 The ability of cyproheptadine (Cph) to inhibit membrane translocation of calcium in smooth muscle was investigated by studying the drug's action on contraction, electrical activity and calcium influx in the guinea-pig taenia coli.2 Cph >/= 10(-6)M reduced the amplitude of normal spontaneous contractions and concurrently decreased the number of action potentials occurring with each slow-wave of depolarization (sucrose-gap recordings). These inhibitory effects of Cph were antagonized by increasing the medium [Ca] three fold to 7.68 mM.3 Intracellular recordings showed that Cph >/= 2 x 10(-6)M decreased the amplitude and extended the duration of the action potential. These effects were only partially reversible in normal medium whereas large overshooting action potentials were again seen in 7.68 mM Ca medium.4 High frequency mechanical activity was produced by inclusion of veratridine 5 x 10(-6)M in the perfusate. Low concentrations of Cph (>/= 10(-7)M) reduced the amplitude of such contractions at a faster rate than they did normal spontaneous contractions.5 At concentrations between 10(-7) and 10(-6)M, Cph fully reduced the tonic component of contractions elicited in 112 mM isotonic KCl whilst having little or no effect on either (i) the initial phasic KCl contraction or (ii) the ;repolarization contracture' normally produced on wash-out of the KCl or (iii) the spontaneous contractions before and after KCl treatment. In contrast, at Cph 2 x 10(-6)M, the repolarization contracture, as well as the isotonic KCl contraction, was totally blocked whereas spontaneous contractions were still unaffected. Progressively higher Cph concentrations inhibited all components of this contractile cycle.6 Dose-response curves for the rate of drug-induced relaxation of tonic contractures produced in hypertonic 42.7 mM high-potassium medium, showed the calcium antagonistic potency of Cph to be intermediate between that of chlorpromazine and D600. The minimum Cph concentration for effect lay between 1 and 5 x 10(-7)M, and the effects of Cph 2 x 10(-6)M (approximately the ID(50)) were totally antagonized by 12.8 mM Ca.7 By means of a lanthanum wash procedure, Cph >/= 2 x 10(-6)M was found to decrease the (45)Ca uptake occurring into strips of taenia coli in normal medium, although the maximum effect (at Cph 10(-5)M) amounted to only 25% inhibition of the uptake occurring into control strips (also found with D600). The increased uptake occurring in hypertonic 44.7 mM high-potassium medium was inhibited in a dose-dependent manner by Cph 1 x 10(-7)M.8 The results are consistent with an action of Cph in reducing the flow of Ca(2+) through voltage-dependent Ca channels in the smooth muscle cell membrane. It is suggested that the interaction of Cph molecules with such sites is dependent upon membrane potential as well as drug concentration.
The antinociceptive effect and adverse drug reactions of oxycodone in human experimental pain in relation to genetic variations in the <i>OPRM1</i> and <i>ABCB1</i> genes (2009)

The aim of this study was to search for a possible association between the variant allele of the single nucleotide polymorphisms A118G in the OPRM1 gene and C3435T and G2677T/A in the ABCB1 gene and altered antinociceptive effect and adverse drug reactions of oxycodone. Thirty-three healthy subjects exposed to experimental pain including electrical stimulation and the cold pressor test were included. A118G: We found that the variant G allele was associated with reduced antinociceptive effect as measured by pain tolerance thresholds to single electrical nerve stimulation (8% increase vs. 25% for the wild-type carriers, P = 0.007). C3435T: The carriers of the variant T allele generally had less adverse drug reactions on oxycodone than the carriers of the wild-type genotype. G2677T/A: The carriers of the variant T allele had a better antinociceptive effect of oxycodone than the carriers of the wild-type genotype in the cold pressor test (25% reduction vs. 15%, P = 0.015 in the discomfort rating and 25% reduction vs. 12%, P = 0.007 in the pain time AUC) and less adverse drug reactions. The combined wild-type genotype 3435CC-2677GG was associated with less antinociceptive effect of oxycodone in the discomfort rating of the cold pressor test (13% reduction vs. 23%, P = 0.019) and more severe adverse drug reactions than the carriers of the variant alleles. We found a moderate association between less antinociceptive effect of oxycodone and the variant allele of A118G. There was strong association between less adverse drug reactions of oxycodone and the variant alleles of C3435T and G2677T/A.
Attenuating the Systemic Inflammatory Response to Adult Cardiopulmonary Bypass: A Critical Review of the Evidence Base (2014)

A wide range of pharmacological, surgical, and mechanical pump approaches have been studied to attenuate the systemic inflammatory response to cardiopulmonary bypass, yet no systematically based review exists to cover the scope of anti-inflammatory interventions deployed. We therefore conducted an evidence-based review to capture "self-identified" anti-inflammatory interventions among adult cardiopulmonary bypass procedures. To be included, trials had to measure at least one inflammatory mediator and one clinical outcome, specified in the "Outcomes 2010" consensus statement. Ninety-eight papers satisfied inclusion criteria and formed the basis of the review. The review identified 33 different interventions and approaches to attenuate the systemic inflammatory response. However, only a minority of papers (35 of 98 [35.7%]) demonstrated any clinical improvement to one or more of the predefined outcome measures (most frequently myocardial protection or length of intensive care unit stay). No single intervention was supported by strong level A evidence (multiple randomized controlled trials [RCTs] or meta-analysis) for clinical benefit. Interventions at level A evidence included off-pump surgery, minimized circuits, biocompatible circuit coatings, leukocyte filtration, complement C5 inhibition, preoperative aspirin, and corticosteroid prophylaxis. Interventions at level B evidence (single RCT) for minimizing inflammation included nitric oxide donors, C1 esterase inhibition, neutrophil elastase inhibition, propofol, propionyl-L-carnitine, and intensive insulin therapy. A secondary analysis revealed that suppression of at least one inflammatory marker was necessary but not sufficient to confer clinical benefit. The most effective interventions were those that targeted multiple inflammatory pathways. These observations are consistent with a "multiple hit" hypothesis, whereby clinically effective suppression of the systemic inflammatory response requires hitting multiple inflammatory targets simultaneously. Further research is warranted to evaluate if combinations of interventions that target multiple inflammatory pathways are capable of synergistically reducing inflammation and improving outcomes after cardiopulmonary bypass.
Software Bug Detection using Data Mining (2015)

The common software problems appear in a wide variety of applications and environments. Some software related problems arises in software project development i.e. software related problems are known as software defect in which Software bug is a major problem arises in the coding implementation .There are no satisfied result found by project development team. The software bug problems mentation in problem report and software engineer does not easily detect this software defect but by the help of data mining classification software engineers easily can classify software bug. This paper classified and detect software bug by J48, ID3 and Nave Bayes data mining algorithms. Comparison of these algorithms to detect accuracy and time taken to build model is also presented in this paper.
Deoxyribonucleic acids and related compounds. XXII Synthesis of genes for human nerve growth factor and its fused protein. (1986)

Gene I and II for human nerve growth factor β-subunit (hNGF) (118 amino acids) were synthesized by enzymatic joining of 45 oligodeoxynucleotides with chain lengths of ca. 17, which were obtained by the phosphotriester solid-phase synthesis. Gene I contained the methionine codon downstream of a restriction site, Cla I, for direct expression under the control of E. coli trp promoter, inserted in a plasmid pGH-L9 (M. Ikehara et al., Proc. Natl. Acad. Sci., 81, 5956 (1984)). Gene II coded for a fused protein containing two-thirds of human growth hormone as well as the sequence Ile-Glu-Gly-Arg, in front of the amino acid sequence of hNGF. Both genes were amplified in E. coli by ligation to restriction sites for Cla I and Sal I of pGH-L9 followed by transformation of E. coli. The molecular weight of the expressed products was estimated by electrophoresis on acrylamide gel. The structure of the gene was characterized by restriction analysis and sequencing.
Role of MicroRNA-155 at Early Stages of Hepatocarcinogenesis Induced by Choline-Deficient and Amino Acid–Defined Diet in C57BL/6 Mice† (2009)

Temporal changes in microRNA profile occur at early stages of CDAA diet-induced hepatocarcinogenesis. Reciprocal regulation of specific oncomirs and their tumor suppressor targets implicate their role in NASH-induced hepatocarcinogenesis and suggest their use in the diagnosis, prognosis, and therapy of liver cancer.
Explant Orientation and Polarity Determine the Morphogenic Response of Epicotyl Segments of Troyer Citrange (1999)

The morphogenic pathway of adventitious bud and shoot regeneration at the ends of Troyer citrange epicotyl cuttings is determined by polarity and explant orientation. In explants planted vertically with the basal end inserted in the medium, bud formation at the apical end occurs by direct organogenesis. Bud growth and subsequent shoot formation is markedly increased by the addition of 6-benzyladenine (BA) to the medium. This growth regulator also increases the number of buds formed. When they come into contact with the culture medium, both the apical end and the basal end of the cuttings form a vigorous callus with many xyllary elements, more numerous in the calli from the basal end. In these calli, buds differentiate by a process of indirect organogenesis. This indirect regeneration pathway requires the addition of 6-benzyladenine to the medium, and the number of buds formed is higher at the apical end than at the basal end of the cuttings. This pathway of regeneration is reduced as the position of the cuttings during incubation deviates from the normal upright vertical position. Thus, for the basal end of the cuttings, the number of buds and shoots formed is higher when the explants are placed vertically than when they lie on the surface of the medium. For the apical end, this number is higher in explants placed horizontally than when inserted vertically in the medium in an inverted position. Copyright 1999 Annals of Botany Company
Mitochondrial cytopathies (2011)

The genetic epilepsy with febrile seizures plus (GEFS+) spectrum is a complex concept to understand and derives from clinical genetic studies. In GEFS+, the clinician needs to understand the presentations that form part of the phenotypic spectrum to consider a familial epilepsy syndrome diagnosis of GEFS+. The characteristic electroencephalograph (EEG) signature is of irregular generalized spike-wave activity; however, this is not present in all affected individuals. All individuals with GEFS+ have seizures, although some have simple febrile seizures whilst others have more severe phenotypes. The main risk factor is fever in infancy and early childhood, however, some family members also have afebrile seizures of various types. As with all forms of epilepsy, seizures are more likely if the patient is tired or stressed. In the more severe phenotypes, multiple antiepileptic agents may be necessary. Often valproate and lamotrigine are useful for myoclonic-astatic epilepsy (MAE).
FinFET based adiabatic logic design for low power applications (2017)

The circuit behaviour in Adiabatic logic and FinFET Technology is studied in detail in the literature so as to improve the ultralow power design. The energy saved by adiabatic logic using FinFET is significant compared to the CMOS. This way of designing a circuit is effective in low speed operations where power consumption is more important than performance. Fin-type field-effect transistors (FinFETs) are promising substitutes for bulk CMOS at the nanoscale. Finfet, a long channel device which improves electrostatic control over device. These low power requirements have emerged due to the advancement in technology where power is more important like medical, mobile phones, hand held devices etc. In subthreshold logic, the circuit operates with supply voltage less than that of the threshold voltage of the transistor and utilizes leakage current as the operating current. This is achieved as the dynamic power consumption is quadratic ally dependent on the supply voltage. To show the results we are implementing 4-bit adder in subthreshold adiabatic logic using FinFET technology which shows that the power consumed by FinFET adiabatic logic will be less than that of normal adiabatic operation operation. The analysis has been carried for 32nm FinFET models using HSPICE simulations. For performance analysis we also used industry standard Cadence® EDA tools.
Clinical Bronchiolitis Obliterans in Workers at a Microwave-Popcorn Plant (2002)

The excess rates of lung disease and lung-function abnormalities and the relation between exposure and outcomes in this working population indicate that they probably had occupational bronchiolitis obliterans caused by the inhalation of volatile butter-flavoring ingredients.
Structural analysis of the gene encoding human gastrin: the large intron contains an Alu sequence. (1984)

We have isolated a human gastrin gene from a genomic library by employing a human gastrin cDNA clone as a hybridization probe. The total length of the gene is approximately 4.0 kilobase pairs, and the gene is separated into three exons and two introns. A 130-base-pair intron interrupts the coding region and a 3.0-kilobase-pair intron is located in the 5' untranslated region. Nucleotide sequence analysis showed that all of the exon-intron boundaries follow the A-G/G-T consensus sequences. A putative transcription initiation site is assigned to the adenine 60 nucleotides upstream from the exon-intron junction on the basis of S1 nuclease protection mapping. A possible "TATA" equivalent sequence T-T-A-T-A-A is located 28 base pairs upstream from the transcription initiation site. A "CAT box" sequence, C-A-T-T, is located 99 nucleotides upstream of the transcription initiation site. A poly(A)-addition signal, A-A-U-A-A-A, is located 80 base pairs downstream from the termination codon. Comparison of the nucleotide sequences of the human cDNA and the genomic clone revealed that the aspartic acid codon at position 71 of preprogastrin is interrupted by the small intron (130 base pairs). The 3' region of the large intron contains a sequence of 300 nucleotides that is flanked by 15-nucleotide direct repeats. This sequence exhibits a striking homology to the human Alu-type sequence.
Interference Strategies (1992)

In addition to determining the legal strategies for an interference, the business strategies of a company must be considered at the earliest opportunity.KeywordsSubject MatterPatent ApplicationLegal StrategyEarly OpportunityFederal CircuitThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Persistence (2018)

We call the phenomenon of objects existing through time, persistence. Theories of persistence aim to spell out the conditions under which objects persist. A useful way to think about this task is to see that in order for an object to persist from one time to another, it needs to be that in some good sense the object that is located at the earlier time, is the same object as the object located at the later time. Competing theories of persistence can be thought of as offering different ways of understanding the sense in which an object located at one time is the same object as an object located at some other time. These different accounts are, in part, motivated by the need to reconcile four apparent truisms: (a) an object persists iff it exists at different times, and at each of those times what exists is numerically identical with what exists at every other one of those times; (b) persisting objects change their intrinsic properties over time; (c) x = y only if x and y share all of the same properties; and (d) no object instantiates incompatible properties. The tension between these four plausible claims is known as the problem of temporary intrinsics, and different attempts to solve the problem lead to different theories of persistence. Historically, there have been two main theories of persistence. The articulation of these theories can be traced to David Lewis, who distinguishes endurance from perdurance. The theory that says that objects persist by enduring is known as endurantism, and the theory that says that objects persist by perduring is known as perdurantism. Put somewhat roughly for now, endurantism is the view that objects persist by being wholly present at more than one time. Perdurantism is the view that objects persist by being partially present at more than one time. Section 1 considers these two theories of persistence in more detail, and then introduces two more recent views: exdurantism (also known as stage theory) and transdurantism. Section 2 considers how these four theories respond to the problem of temporary intrinsics.
Functional complementation of nuclear targeting-defective mutants of simian virus 40 structural proteins (1994)

Structural proteins of simian virus 40 (SV40), Vp2 and Vp3 (Vp2/3) and Vp1, carry individual nuclear targeting signals, Vp3(198-206) (Vp2(316-324) and Vp1(1-8), respectively, which are encoded in different reading frames of an overlapping region of the genome. How signals coordinate nuclear targeting during virion morphogenesis was examined by using SV40 variants in which there is only one structural gene for Vp1 or Vp2/3, nuclear targeting-defective mutants thereof, Vp2/3(202T) and Vp1 delta N5, or nonoverlapping SV40 variants in which the genes for Vp1 and Vp2/3 are separated, and mutant derivatives of the gene carrying either one or both mutations. Nuclear targeting was assessed immunocytochemically following nuclear microinjection of the variant DNAs. When Vp2/3 and Vp1 mutants with defects in the nuclear targeting signals were expressed individually, the mutant proteins localized mostly to the cytoplasm. However, when mutant Vp2/3(202T) was coexpressed in the same cell along with wild-type Vp1, the mutant protein was effectively targeted to the nucleus. Likewise, the Vp1 delta N5 mutant protein was transported into the nucleus when wild-type Vp2/3 was expressed in the same cells. These results suggest that while Vp1 and Vp2/3 have independent nuclear targeting signals, additional signals, such as those defining protein-protein interactions, play a concerted role in nuclear localization along with the nuclear targeting signals of the individual proteins.
Synthesis of Some Peptides Corresponding to the Active Region of Rantes for Chemotaxis and Evaluation of Their Anti-human Immunodeficiency Virus-1 Activity. (1997)

Five peptides corresponding to the amino-terminal sequence of RANTES (regulated upon activation, normal T-cell expressed and secreted), which is known to be the critical region for chemotaxis, were synthesized, and their anti-human immunodeficiency virus (HIV)-1 activity was examined to obtain a lead compound useful for the development of chemokine receptor-directed anti-HIV-1 drugs. A decapeptide corresponding to positions 1-10 [Ac-(10Ala-RANTES 1-10)-NH2] showed significant anti-HIV-1 activity. Ac-(10Ala, 11Ala-RANTES 5-14)-NH2 was also active, but less potent than the former. Other peptides corresponding to the positions 6-14, 7-14, and 8-14 did not show anti-HIV-1 activity. These results indicate that the sequence 1-10 of RANTES is important for the anti-HIV-1 effect.