gebhart/patrepeval huggingface dataset:
Cannabidiol inhibits lung cancer cell invasion and metastasis <i>via</i> intercellular adhesion molecule‐1 (2011)

Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell lines A549, H358, and H460, cannabidiol (CBD; 0.001-3 μM) elicited concentration-dependent ICAM-1 up-regulation compared to vehicle via cannabinoid receptors, transient receptor potential vanilloid 1, and p42/44 mitogen-activated protein kinase. Up-regulation of ICAM-1 mRNA by CBD in A549 was 4-fold at 3 μM, with significant effects already evident at 0.01 μM. ICAM-1 induction became significant after 2 h, whereas significant TIMP-1 mRNA increases were observed only after 48 h. Inhibition of ICAM-1 by antibody or siRNA approaches reversed the anti-invasive and TIMP-1-upregulating action of CBD and the likewise ICAM-1-inducing cannabinoids Δ(9)-tetrahydrocannabinol and R(+)-methanandamide when compared to isotype or nonsilencing siRNA controls. ICAM-1-dependent anti-invasive cannabinoid effects were confirmed in primary tumor cells from a lung cancer patient. In athymic nude mice, CBD elicited a 2.6- and 3.0-fold increase of ICAM-1 and TIMP-1 protein in A549 xenografts, as compared to vehicle-treated animals, and an antimetastatic effect that was fully reversed by a neutralizing antibody against ICAM-1 [% metastatic lung nodules vs. isotype control (100%): 47.7% for CBD + isotype antibody and 106.6% for CBD + ICAM-1 antibody]. Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness.
Sputum matrix metalloproteinase‐8 and ‐9 and tissue inhibitor of metalloproteinase‐1 in bronchiectasis: Clinical correlates and prognostic implications (2015)

Sputum MMP might be useful biomarkers for the assessment of bronchiectasis severity and the prediction of future risks of BE. Our results provide the rationales for the future clinical application of MMP inhibitors.
Third-order nonlinearities in silicon at telecom wavelengths (2003)

The two-photon absorption coefficient and Kerr coefficient of bulk crystalline silicon are determined near the telecommunication wavelengths of 1.3 and 1.55 μm using femtosecond pulses and a balanced Z-scan technique. A phase shift sensitivity of the order of 1 mrad is achieved, enabling the accurate measurement of third-order nonlinear coefficients at fluences smaller than 100 μJ/cm2. From the two-photon absorption coefficient (β∼0.8 cm/GW) and the Kerr coefficient (n2∼4×10−14 cm2/W) at a wavelength λ=1.54 μm, a value F∼0.35 for the nonlinear figure of merit for all-optical switching is determined.
Effective race detection for event-driven programs (2013)

Like shared-memory multi-threaded programs, event-driven programs such as client-side web applications are susceptible to data races that are hard to reproduce and debug. Race detection for such programs is hampered by their pervasive use of ad hoc synchronization, which can lead to a prohibitive number of false positives. Race detection also faces a scalability challenge, as a large number of short-running event handlers can quickly overwhelm standard vector-clock-based techniques.
Video retargeting (2006)

When a video is displayed on a smaller display than originally intended, some of the information in the video is necessarily lost. In this paper, we introduce Video Retargeting that adapts video to better suit the target display, minimizing the important information lost. We define a framework that measures the preservation of the source material, and methods for estimating the important information in the video. Video retargeting crops each frame and scales it to fit the target display. An optimization process minimizes information loss by balancing the loss of detail due to scaling with the loss of content and composition due to cropping. The cropping window can be moved during a shot to introduce virtual pans and cuts, subject to constraints that ensure cinematic plausibility. We demonstrate results of adapting a variety of source videos to small display sizes.
Chemical Modification of <i>n</i>-Type-Material Naphthalene Diimide on ITO for Efficient and Stable Inverted Polymer Solar Cells (2017)

To provide orthogonal solvent processable surface modification and improve the device stability of bulk-heterojunction polymer solar cells (PSCs), n-type semiconducting material naphthalene diimide (NDI) was chemically introduced onto the ITO surface as a cathode interlayer (CIL) using 3-bromopropyltrimethoxysilane (BrTMS) as a coupling agent. After modification, the work function of ITO can be decreased from 4.70 to 4.23 eV. The modified ITO cathode was applied in inverted PSCs based on PTB7-Th:PC<sub>71</sub>BM. With the CIL modification, a champion power conversion efficiency (PCE) of 5.87% was achieved, showing a dramatic improvement compared to that of devices (PCE = 3.58%) without CIL. More importantly, with these chemical bonded interlayers, the stability of inverted PSCs was greatly enhanced. The improved PCE and stability can be attributed to the increased open-circuit voltage and the formation of robust chemical bonds in NDI-TMS films, respectively. This study demonstrated that chemical modification of ITO with n-type semiconducting materials provides an avenue for not only solving the solvent orthogonal problem but also improving the device performance in terms of the PCE and the stability.
Wear and Friction of Ni-P Electroless Composite Coating Including Inorganic Fullerene-WS2 Nanoparticles (2002)

It was proposed that nanoparticles of layered compounds are not stable in the planar form and they spontaneously fold into fullerene-like structures and nanotubes (IF phases). Considering the spherical topology of the IF nanoparticles, it was proposed that they could ideally suit tribological applications. In this paper the authors demonstrate the preparation of a metal matrix IF-nanoparticles composite coating by electroless codeposition. It was found that the IF-nanoparticle was able to significantly improve the tribological characteristics of the electroless composite coatings. Moreover, the spherical IF nanoparticles can promote easier sliding between the two mating metal surface.
Rheological profiles of blends of the new and used motor oils (2013)

The objective of this paper is to find changes of a rheological profile of the new engine oil if the used engine oil will be add. And also find changes of a rheological profile of the used engine oil if the new engine oil will be add. For these experiments has been created the blends of the new and the used engine oil. The temperature dependence of the density [kg.m-3] has been measured in the range of -10 Â°C and +60 Â°C. The instrument Densito 30PX with the scale for measuring engine oils has been used. The dynamic viscosity [mPa.s] has been measured in the range of -10 Â°C and +100 Â°C. The Anton Paar digital viscometer with the concentric cylinders geometry has been used. In the accordance with the expected behaviour, the density and the kinematic viscosity of all oils was decreasing with the increasing temperature. To the physical properties has been the mathematical models created. For the temperature dependence of the density has been used the linearly mathematical model and the exponentially mathematical model. For the temperature dependence of the dynamic viscosity has been used the polynomial 6th degree. The knowledge of density and viscosity behaviour of an engine oil as a function of its temperature is of great importance, especially when considering running efficiency and performance of combustion engines. Proposed models can be used for description and prediction of rheological behaviour of engine oils.
Anchor Box Optimization for Object Detection (2020)

In this paper, we propose a general approach to optimize anchor boxes for object detection. Nowadays, anchor boxes are widely adopted in state-of-the-art detection frameworks. However, these frameworks usually pre-define anchor box shapes in heuristic ways and fix the sizes during training. To improve the accuracy and reduce the effort of designing anchor boxes, we propose to dynamically learn the anchor shapes, which allows the anchors to automatically adapt to the data distribution and the network learning capability. The learning approach can be easily implemented with stochastic gradient descent and can be plugged into any anchor box-based detection framework. The extra training cost is almost negligible and it has no impact on the inference time or memory cost. Exhaustive experiments demonstrate that the proposed anchor optimization method consistently achieves significant improvement (≥ 1% mAP absolute gain) over the baseline methods on several benchmark datasets including Pascal VOC 07+12, MS COCO and Brainwash. Meanwhile, the robustness is also verified towards different anchor initialization methods and the number of anchor shapes, which greatly simplifies the problem of anchor box design.
Direct Synthesis of 2,2-Diaryl-3-methyl-2,3-dihydrobenzothiazoles from 3-Methyl-2,3-dihydrobenzothiazole-2-thione and Some Mechanistic Aspects (1979)

Abstract Reactions of 3-methyl-2,3-dihydrobenzothiazole-2-thione (1) and 3-methyl-2-(methylthio)benzothiazoliumiodide with Grignard reagents gave 2,2-disubstituted 3-methyl-2,3-dihydrobenzothiazole (2) as a major product as well as 2,2′-disubstituted 3,3′-dimethyl-2,2′,3,3′-tetrahydrobi(2-benzothiazolyl) (3). Reactions of 1 with organolithiums gave 2 as a major product. The results demonstrate that the formation of 3 is due to the presence of transition metals as an impurity in magnesium.
Role and effective treatment of dispersive forces in materials: Polyethylene and graphite crystals as test cases (2008)

A semiempirical addition of dispersive forces to conventional density functionals (DFT-D) has been implemented into a pseudopotential plane-wave code. Test calculations on the benzene dimer reproduced the results obtained by using localized basis set, provided that the latter are corrected for the basis set superposition error. By applying the DFT-D/plane-wave approach a substantial agreement with experiments is found for the structure and energetics of polyethylene and graphite, two typical solids that are badly described by standard local and semilocal density functionals.
Synthesis and physical properties of liquid crystal compounds having an alkoxyalkyl moiety at the asymmetric center (1993)

Abstract Novel antiferroelectric liquid crystal compounds, having an alkoxyalkyl moiety at the asymmetric center, were synthesized and their properties were studied.
Affective multimodal human-computer interaction (2005)

Social and emotional intelligence are aspects of human intelligence that have been argued to be better predictors than IQ for measuring aspects of success in life, especially in social interactions, learning, and adapting to what is important. When it comes to machines, not all of them will need such skills. Yet to have machines like computers, broadcast systems, and cars, capable of adapting to their users and of anticipating their wishes, endowing them with the ability to recognize user's affective states is necessary. This article discusses the components of human affect, how they might be integrated into computers, and how far are we from realizing affective multimodal human-computer interaction.
Can GPCR, such as Kappa Opioid Receptor, be a Viable Therapeutic Target for Reducing or Preventing Neuroinflammation? (2014)

Copyright: © 2014 Park SW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. G protein-coupled receptors (GPCRs) are 7-transmembrane domain containing proteins that mediate a wide range of biological processes and are the most favored drug targets. Approximately 40% of modern drugs are designed to target specific GPCRs, directly as agonists or antagonists, or indirectly as modulators to intervene in the pathophysiological processes of diseases. For most neurological disorders where GPCR could contribute to disease progression, particularly those of chronic in nature, inflammation in the brain seems to be the culprit.
Acute secondhand smoke-induced pulmonary inflammation is diminished in RAGE knockout mice (2014)

The receptor for advanced glycation end-products (RAGE) has increasingly been demonstrated to be an important modulator of inflammation in cases of pulmonary disease. Published reports involving tobacco smoke exposure have demonstrated increased expression of RAGE, its participation in proinflammatory signaling, and its role in irreversible pulmonary remodeling. The current research evaluated the in vivo effects of short-term secondhand smoke (SHS) exposure in RAGE knockout and control mice compared with identical animals exposed to room air only. Quantitative PCR, immunoblotting, and immunohistochemistry revealed elevated RAGE expression in controls after 4 wk of SHS exposure and an anticipated absence of RAGE expression in RAGE knockout mice regardless of smoke exposure. Ras activation, NF-κB activity, and cytokine elaboration were assessed to characterize the molecular basis of SHS-induced inflammation in the mouse lung. Furthermore, bronchoalveolar lavage fluid was procured from RAGE knockout and control animals for the assessment of inflammatory cells and molecules. As a general theme, inflammation coincident with leukocyte recruitment was induced by SHS exposure and significantly influenced by the availability of RAGE. These data reveal captivating information suggesting a role for RAGE signaling in lungs exposed to SHS. However, ongoing research is still warranted to fully explain roles for RAGE and other receptors in cells coping with involuntary smoke exposure for prolonged periods of time.
Viscosity of aqueous solutions of polysaccharides and their carboxylate derivatives (1990)

Abstract The viscosities of aqueous solutions of methyl cellulose, dextran, and their carboxymethyl derivatives were measured as functions of molecular weight and concentration. Furthermore, effects of ionic group and added salt on the viscosity of aqueous solutions of carboxymethyl derivatives were investigated. The viscosities of dextran and carboxymethyl dextran solutions did not show any shear stress dependence, but those of methyl and carboxymethyl cellulose solutions strongly depended on shear stress even at low concentrations. The results were discussed on the basis of the points of molecular structure and hydration and ionic interaction of a polymer chain in solutions.
Genomic diversity of enterohemorrhagic <i>Escherichia coli</i> O157 revealed by whole genome PCR scanning (2002)

Enterohemorrhagic Escherichia coli O157 is one of the leading worldwide public health concerns, causing large outbreaks of hemorrhagic colitis as well as numerous small outbreaks and sporadic cases. The variability of restriction enzyme-digestion patterns of O157 genomes, which is widely used to distinguish strains in the molecular epidemiology of O157 infections, suggests the presence of some genomic diversity among the strains. Based on the complete genome sequence of O157 Sakai, we analyzed the whole genome structures of eight O157 strains displaying diverse XbaI-digestion patterns by a systematic PCR analysis that we have named whole genome PCR scanning. This analysis identified not only the O157-specific sequences that are highly conserved among the strains, but also revealed an unexpectedly high degree of genomic diversity. In particular, prophages, including Shiga toxin-transducing phages, exhibited extensive structural and positional diversity, implying that variation of bacteriophages is a major factor in generating genomic diversity among the O157 lineage.
Autofluorescence maps of atherosclerotic human arteries--A new technique in medical imaging (1987)

A new medical imaging technique for arterial walls based on laser-induced autoflnorescence spectroscopy is reported. The internal surface of isolated arteries with or without atherosclerosis is irradiated with an argon ion laser (458 nm) and the peak intensity of the excited autofluorescence spectrum is related to the composition of the arterial wall. The higher autofluorescence intensity in the range between approximately 480 and 630 nm for grossly calcified tissue compared to normal or noncalcified atherosclerotic tissue is used to produce maps of the arterial wall. These images delineate the calcified areas of the sample with good spatial resolution. If this technique can be adapted to the endoscopic visualization of arteries in vivo (angios, Copy), it could become an important tool for the diagnosis of atherosclerosis and for the monitoring of atheroma ablation during laser angioplasty.
Techniques for optimal DSSS code selection for SAW multi-sensor systems (2012)

Direct Sequence Spread Spectrum (DSSS) codes have a variety of applications, including implementing code diversity in wireless surface acoustic wave (SAW) multi-sensor systems. Such systems generally suffer from code collision problems, necessitating complex post-processing to avoid negatively impacting sensor calibration and system accuracy. Thus, development of groups of codes that exhibit very low cross-correlation is desirable to implement code diversity in passive wireless sensor systems. This paper discusses generation and analysis of Gold codes, a know class of codes with desirable cross-correlation properties. A logical criteria-based method for the `exhaustive' analysis of codes of a given length is also presented, applying a selected set of screening techniques to rapidly evaluate all possible candidate codes to a sufficient degree. Using this technique, sets of codes can be found that perform well in asynchronous correlation-based wireless sensor systems, reducing the need for complex post-processing.
MEMBRANE GAS SEPARATION. (1986)

Revue des travaux actuels, en particulier, analyse des permeateurs a membranes asymetriques: vitesses de transfert du gaz et separation a travers les membranes; compositions et configurations des membranes; analyse d'un permeateur pour la separation d'un binaire; schemas de separation pour la separation d'un binaire; separation d'un melange complexe de gaz; methode de conception; procedes de separation des gaz par membrane
Drug Repurposing: Far Beyond New Targets for Old Drugs (2012)

Repurposing drugs requires finding novel therapeutic indications compared to the ones for which they were already approved. This is an increasingly utilized strategy for finding novel medicines, one that capitalizes on previous investments while derisking clinical activities. This approach is of interest primarily because we continue to face significant gaps in the drug-target interactions matrix and to accumulate safety and efficacy data during clinical studies. Collecting and making publicly available as much data as possible on the target profile of drugs offer opportunities for drug repurposing, but may limit the commercial applications by patent applications. Certain clinical applications may be more feasible for repurposing than others because of marked differences in side effect tolerance. Other factors that ought to be considered when assessing drug repurposing opportunities include relevance to the disease in question and the intellectual property landscape. These activities go far beyond the identification of new targets for old drugs.
Synthesis of Block Polymers for Desalination Membranes. Preparation of Block Copolymers of 2-Vinylpyridine and Methacrylic Acid or Acrylic Acid (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Block Polymers for Desalination Membranes. Preparation of Block Copolymers of 2-Vinylpyridine and Methacrylic Acid or Acrylic AcidM. Kamachi, M. Kurihara, and J. K. StilleCite this: Macromolecules 1972, 5, 2, 161–167Publication Date (Print):March 1, 1972Publication History Published online1 May 2002Published inissue 1 March 1972https://pubs.acs.org/doi/10.1021/ma60026a013https://doi.org/10.1021/ma60026a013research-articleACS PublicationsRequest reuse permissionsArticle Views1138Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of blocking contacts on generation-recombination noise and responsivity in intrinsic photoconductors (1984)

A theory is presented of generation-recombination (g-r) noise, responsivity, and detectivity D* in intrinsic photoconductors, including for the first time the effects of recombination at the contacts as a variable parameter. The contacts are described using a contact recombination velocity. Increasing the blocking at the contacts can significantly increase the responsivity, and also push the detectivity toward the background limited value since blocking contacts increase responsivity and the background contribution to the noise voltage faster than the thermal contribution. Blocking contacts also cause both the responsivity and g-r noise voltage to roll off at lower frequencies. Numerical calculations are presented for X∼0.2 HgCdTe photoconductors. Blocking contacts are found to increase the range of material parameters which can be used to make detectors. For example, under typical conditions, to reach responsivities of 105 V/W and detectivities of 6×1010 cm(Hz)1/2/W at T=77 °K, blocking contacts can increase the maximum allowed carrier density from about 4×1014 to about 2×1015 cm−3, and enlarge the required composition window from about 0.200&lt;x&lt;0.212 to about 0.188&lt;x&lt;0.212 for typical device geometries.
Switchable counterion gradients around charged metallic nanoparticles enable reception of radio waves (2018)

Mechanically flexible, easy-to-process, and environmentally benign materials capable of current rectification are interesting alternatives to "hard" silicon-based devices. Among these materials are metallic/charged-organic nanoparticles in which electronic currents though metal cores are modulated by the gradients of counterions surrounding the organic ligands. Although layers of oppositely charged particles can respond to both electronic and chemical signals and can function even under significant mechanical deformation, the rectification ratios of these "chemoelectronic" elements have been, so far, low. This work shows that significantly steeper counterion gradients and significantly higher rectification ratios can be achieved with nanoparticles of only one polarity but in contact with a porous electrode serving as a counterion "sink." These composite structures act as rectifiers even at radio frequencies, providing a new means of interfacing counterions' dynamics with high-frequency electronic currents.