gebhart/patrepeval huggingface dataset:
A convenient solvothermal route to ruthenium nanoparticles (2000)

A convenient solvothermal route has been developed to prepare ruthenium nanoparticles, which have been characterized by X-ray diffraction, transmission electron microscopy and other techniques.
Automated Damage Assessment from High Resolution Remote Sensing Imagery (2022)

Estimating the extent of damage caused by natural disasters is necessary for implementing effective recovery measures. Damage detection from high-resolution satellite or aerial imagery for post-disaster analysis has been a major research effort in the past decade. A careful analysis of images from before and after an event facilitates rapid detection and assessment of building damage. This work presents a first-of-its-kind system for automatic damage assessment. The proposed framework for damage estimation consists of three steps. First the pre-event and post-event images are registered automatically. A SURF-based feature extraction and matching technique is used for automatic image registration. Next, the objects of interests such as buildings are extracted from pre-storm images. A novel robust algorithm for building detection is proposed and evaluated. Lastly, change detection is performed and damage is classified using supervised learning algorithms. Relevant features that reflect the spectral properties of damaged buildings are identified and used to classify the damage level into various states.
Tumour Necrosis Factor Enhances induction by beta-Interferon of a Ubiquitin Cross-reactive Protein (1990)

Tumour necrosis factor alpha (TNF-alpha) elicited an antiviral response in some cell lines (MG-63 and HEp-2) but not in others (MDBK). Cell lines that generated an antiviral response to TNF-alpha also showed induction of a 15K protein which shared sequence homology with ubiquitin and reacted with an antibody to ubiquitin. This ubiquitin cross-reactive protein (UCRP) had been demonstrated previously to be induced by interferon. The TNF-alpha induction of UCRP occurred at the level of transcription. TNF-alpha induction of both the antiviral state and the 15K protein was blocked by either monoclonal or polyclonal anti-beta-interferon (IFN-beta) antibody. However no measurable increase in the mRNA specific for IFN-beta was detected after TNF-alpha treatment. Nonetheless, in supernatants from cell cultures, the presence of an antiviral activity inhibitable by anti-IFN-beta antibody indicates that these cells are making IFN-beta already. We conclude that the TNF-alpha induction of antiviral activity and UCRP in cells is dependent upon the presence of constitutive low levels of IFN-beta in the responding cells. Furthermore TNF functions to enhance the existing IFN-beta activity.
On the complexity of some coding problems (Corresp.) (1981)

It is shown that the problem of finding a codeword with least weight and whose weight is not a multiple of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</tex> in a binary linear code belongs to the class of "nondeterministic polynomial (NP)-hard" problems for any <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k\geq 2</tex> . Some other related problems are shown to belong to the same class. These results were motivated by a conjecture due to Berlekamp, McEliece, and van Tilborg that the problem of finding the Hamming distance of a code is NP-hard.
Prevention of Lyme Disease (2000)

This Policy Statement was retired October 2003. Lyme disease is currently the most frequently reported vector-borne illness in the United States, accounting for more than 95% of such cases. The purpose of this report is to provide recommendations for preventing Lyme disease, including the use of Lyme disease vaccine. Individuals can reduce their risk of Lyme disease by avoiding tick-infested habitats when in endemic areas. If exposure to tick-infested habitats cannot be avoided, individuals may reduce their risk of infection by using repellents, wearing protective clothing, and regularly checking for and removing attached ticks. Morbidity from Lyme disease can be reduced significantly by detecting and treating the infection in its early stages; early and appropriate treatment almost always results in a prompt and uncomplicated cure. A Lyme disease vaccine (LYMErix, SmithKline Beecham, Collegeville, PA) was licensed by the US Food and Drug Administration on December 21, 1998, for persons 15 to 70 years of age. This vaccine seems to be safe and effective, but whether its use is cost-effective has yet to be clearly established. Use of this vaccine causes false-positive enzyme immunoassay results for Lyme disease. Lyme disease can be diagnosed in vaccinated persons by immunoblot testing. Decisions about the use of this vaccine should be based on an assessment of a person's risk as determined by activities and behaviors relating to tick exposure in endemic areas. This vaccine should be considered an adjunct to, not a replacement for, the practice of personal protective measures against tick exposure and the early diagnosis and treatment of Lyme disease.
Recent progress in the development of selective S1P1 receptor agonists for the treatment of inflammatory and autoimmune disorders (2008)

Background: The sphingosine-1-phosphate receptor 1 (S1P1) belongs to the endothelial differentiation gene family of G-protein-coupled receptors involved in embryonic development, cellular different...
A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel (2014)

There is wide variation in response to antiplatelet therapy and high on-treatment platelet reactivity is associated with adverse cardiovascular events. The objective here was to determine whether the results of a novel strategy for assessing platelet reactivity (based on P-selectin measurement) are associated with clinical outcomes in patients with acute coronary syndromes (ACS). This was a prospective cohort study of 100 ACS patients taking aspirin and clopidogrel. P-selectin tests designed to assess response to P2Y12 antagonists or aspirin were performed alongside light transmission aggregometry. For the P2Y12 P-selectin test, an optimal cutoff for high platelet reactivity was determined by receiver operating characteristic (ROC) curve analysis. Patients were divided into two cohorts based on this value: patients with (n = 42) or without (n = 58) high platelet reactivity. The primary endpoint was defined as the composite of cardiovascular death, myocardial infarction and stent thrombosis. After 12 months, the primary endpoint occurred in 12 patients. ROC curve analysis determined that the P2Y12 P-selectin test results were predictive of the primary endpoint (area under curve = 0.69, p = 0.046). The primary endpoint occurred more frequently in patients with high on-treatment platelet reactivity compared to those without (21.4% vs. 5.2%; hazard ratio (HR) 4.14; p = 0.026). The P2Y12 P-selectin test results correlated with light transmission aggregometry (Spearman p < 0.0001). Using the Aspirin P-selectin test, only two patients demonstrated high on-treatment platelet reactivity. This study suggests that a P2Y12 P-selectin test is capable of detecting high on-treatment platelet reactivity, which is associated with subsequent cardiovascular events.
Mechanical, chemical, biological: Moving towards closed-loop bio-based recycling in a circular economy of sustainable textiles (2021)

The textile industry is facing increasing criticism because of its intensive use of resources –both natural and fossil derived– and the negative environmental and societal impacts associated with the manufacturing, use and disposal of clothes. This has led to a desire to move towards a circular economy for textiles that will implement recycling concepts and technologies to protect resources, the environment and people. So far, recycling processes have been focused on the chemical and mechanical reuse of textile fibres. In contrast, bio-based processes for textile production and recycling have received little attention, beyond end-of-life composting. However, the selectivity and benign processing conditions associated with bio-based technologies hold great promise for circularising the textile life cycle and reducing the environmental impacts of textile production and processing. Developing circular and sustainable systems for textile production requires a revolutionary system approach that encompasses the choice of material and finishes being designed for recycling at the end of life, and in this context bio-based processes can help provide the means to maintain materials in a closed loop. This paper reviews established methods in mechanical and chemical recycling processes in closed-loop textile recycling of all fibre types, as well as bio-based processes that demonstrate open-loop textile recycling. Fermentation and enzymatic processes have been demonstrated for the production of all types of textiles, which in combination with enzymatic deconstruction of end of life cellulosic textiles could allow them to be recycled indefinitely. Within the context of the circular economy, bio-based processes could extend mechanical and chemical textile recycling mechanisms in the technical cycle, enabling greater circularity of textiles in the biological cycle before composting takes place.
Complete Guide to Semiconductor Devices (2010)

A definitive and up-to-date handbook of semiconductor devices Semiconductor devices, the basic components of integrated circuits, are responsible for the rapid growth of the electronics industry over the past fifty years. Because there is a growing need for faster and more complex systems for the information age, existing semiconductor devices are constantly being studied for improvement, and new ones are being continually invented. As a result, a large number of types and variations of devices are available in the literature. The Second Edition of this unique engineering guide continues to be the only available complete collection of semiconductor devices, identifying 74 major devices and more than 200 variations of these devices. As in the First Edition, the value of this text lies in its comprehensive, yet highly readable presentation and its easy-to-use format, making it suitable for a wide range of audiences. . Essential information is presented for a quick, balanced overview. Each chapter is designed to cover only one specific device, for easy and focused reference. Each device is discussed in detail, always including its history, its structure, its characteristics, and its applications The Second Edition has been significantly updated with eight new chapters, and the material rearranged to reflect recent developments in the field. As such, it remains an ideal reference source for graduate students who want a quick survey of the field, as well as for practitioners and researchers who need quick access to basic information, and a valuable pragmatic handbook for salespeople, lawyers, and anyone associated with the semiconductor industry
Potent Agonists of the Protease Activated Receptor 2 (PAR<sub>2</sub>) (2011)

Novel peptidomimetic pharmacophores to PAR(2) were designed based on the known activating peptide SLIGRL-NH(2). A set of 15 analogues was evaluated with a model cell line (16HBE14o-) that highly expresses PAR(2). Cells exposed to the PAR(2) activating peptide with N-terminal 2-furoyl modification (2-furoyl-LIGRLO-NH(2)) initiated increases in intracellular calcium concentration ([Ca(2+)](i) EC(50) = 0.84 μM) and in vitro physiological responses as measured by the xCELLigence real time cell analyzer (RTCA EC(50) = 138 nM). We discovered two selective PAR(2) agonists with comparable potency: compound 1 (2-aminothiazol-4-yl; Ca(2+) EC(50) = 1.77 μM, RTCA EC(50) = 142 nM) and compound 2 (6-aminonicotinyl; Ca(2+) EC(50) = 2.60 μM, RTCA EC(50) = 311 nM). Unlike the previously described agonist, these novel agonists are devoid of the metabolically unstable 2-furoyl modification and thus provide potential advantages for PAR(2) peptide design for in vitro and in vivo studies. The novel compounds described herein also serve as a starting point for structure-activity relationship (SAR) design and are, for the first time, evaluated via a unique high throughput in vitro physiological assay. Together these will lead to discovery of more potent agonists and antagonists of PAR(2).
Sharpen the Correlation Peak: A Novel GNSS Receiver Architecture with Variable IF Correlation (2016)

Correlation plays a critical role in the operation of a GNSS receiver. However, correlator design faces a dilemma. Fast acquisition favors a wider correlation peak for fewer search grid points while accurate tracking needs a narrower one. With a narrower peak, a receiver can better reduce the detrimental effect of multipath and spoofing signals. A code with a wider bandwidth produces a sharper peak, e.g., GPS P(Y)-code (10.23 MHz) vs. C/A-code (1.023 MHz). A code with more energy toward the band edges also has a sharper peak, e.g., GPS M-code (BOC) vs. P(Y)-code (BPSK). However, a BOC code develops secondary peaks with significant strength, which are ambiguous and may lead to false lock. In this paper, we propose a new receiver architecture that performs correlation at a variable intermediate frequency (IF). By up-converting the code replica to a suitable IF, we effectively perform a joint code and carrier correlation, which has the ability to afford a correlation peak as sharp as the upper IF allows. By progressively varying the IF, we not only sharpen the correlation peak but also provide an easy and reliable means to lock onto the main peak among secondary peaks without ambiguity and false lock. The principle of correlation at variable IF is described in this paper together with implementation options. Simulation results are presented to demonstrate the viability of the new receiver architecture. Copyright © 2016 Institute of Navigation
Gigahorse: Thorough, Declarative Decompilation of Smart Contracts (2019)

The rise of smart contracts - autonomous applications running on blockchains - has led to a growing number of threats, necessitating sophisticated program analysis. However, smart contracts, which transact valuable tokens and cryptocurrencies, are compiled to very low-level bytecode. This bytecode is the ultimate semantics and means of enforcement of the contract. We present the Gigahorse toolchain. At its core is a reverse compiler (i.e., a decompiler) that decompiles smart contracts from Ethereum Virtual Machine (EVM) bytecode into a highlevel 3-address code representation. The new intermediate representation of smart contracts makes implicit data- and control-flow dependencies of the EVM bytecode explicit. Decompilation obviates the need for a contract's source and allows the analysis of both new and deployed contracts. Gigahorse advances the state of the art on several fronts. It gives the highest analysis precision and completeness among decompilers for Ethereum smart contracts - e.g., Gigahorse can decompile over 99.98% of deployed contracts, compared to 88% for the recently-published Vandal decompiler and under 50% for the state-of-the-practice Porosity decompiler. Importantly, Gigahorse offers a full-featured toolchain for further analyses (and a “batteries included” approach, with multiple clients already implemented), together with the highest performance and scalability. Key to these improvements is Gigahorse's use of a declarative, logic-based specification, which allows high-level insights to inform low-level decompilation.
Standoff explosives trace detection and imaging by selective stimulated Raman scattering (2013)

We introduce a sensitive method for laser based standoff detection of chemicals based on stimulated Raman scattering. Selective excitation of a particular Raman transition is detected by measuring the diffusely reflected laser light from a distant surface. The method simultaneously measures stimulated Raman loss and gain within a single laser shot and is insensitive to the optical properties (reflectivity/absorptivity) of the substrate. We demonstrate the specificity and sensitivity by detecting and imaging nanogram analyte micro-crystals on paper, fabric, and plastic substrates at 1 to 10 m standoff distance using only 10 mW of laser power from a single femtosecond laser.
Novel thin film polymer foaming technique for low and ultra low-k dielectrics (2002)

The results presented show a novel route for the preparation of thin ultra-low-k polymer films based on commercial and "non-exotic" (non-expensive) polyimide by a foaming technique. Dependent on the glass transition temperature of the polyimide mechanically and thermally stable (> 300 /spl deg/C) films having porosities of ca. 40 % and k-values below 2.0 are formed. A further reduction into the ultra low k region may be accomplished by tailoring the shape of the pores from spherical into disc-like voids.
The IGF system in in-vitro human decidualization (2008)

Decidualization of endometrial stromal cells (ESCs) is critical for a successful pregnancy but the molecular mechanisms of the process are poorly understood. In this study, we investigated whether the insulin-like growth factor (IGF) network is involved in this cellular process. Expression kinetics of members of the IGF system was examined at both mRNA and protein levels during in-vitro decidualization of cultured human ESCs. We found a significant up-regulation of IGF-II as well as of IGF-I receptor and the A and B insulin receptor (InsR) isoforms. In addition, levels of the key adaptor proteins insulin receptor substrate 1 (IRS-1) and IRS-2 increased, suggesting a potential involvement of the IGF signalling pathway in the decidualization process. Expression of two IGF binding proteins, IGFBP-1 and IGFBP-4, which can inhibit IGF action, also increased. In order to determine whether IGF signalling was activated during decidualization, the phosphorylation status of the receptors and the adaptor proteins was estimated. Only IRS-2 was slightly phosphorylated in decidualized cells and was further activated by the addition of exogenous IGF-II. These results suggest that the IGF signalling pathway could play a crucial role in the functions of decidualized endometrial cells.
Effect of carrier system on the yield of human oocytes and embryos as assessed by survival and developmental potential after vitrification (2002)

The present study was undertaken to examine the effect of a cooling regimen during vitrification on survival and morphological appearance of human oocytes after warming and the developmental potential of day 3 embryos. Aged human oocytes that had failed to fertilize and human embryos derived from abnormally fertilized zygotes that showed one pronucleus or three or more pronuclei were used as models in this study. In the first part of the study, 928 aged human oocytes that had failed to fertilize were vitrified. The viability of oocytes after vitrification using the hemi-straw system was slightly higher than it was using the cryoloop after warming (85.4% (410 of 480) versus 80.6% (361 of 448)), but the difference was not significant. In the second part of the study, 266 embryos were vitrified. The survival of day 3 embryos after vitrification was improved by using a mixture of ethylene glycol and dimethyl sulphoxide in combination with the hemi-straw system method rather than the cryoloop method (89.7% (122 of 136) versus 83.8% (109 of 130)), but the difference was again not significant. The potential for development up to compaction on day 4 in embryos vitrified using the hemi-straw system method was significantly higher (37.7%) than it was in embryos vitrified using the cryoloop (29.4%; chi(2), P = 0.002). The hemi-straw system and cryoloop methods of vitrification are both successful, easy to perform, and demonstrate the ability of both carriers to vitrify different stages of development (oocytes and day 3 embryos). In addition, the success of both methods appears to be related to the rate of cooling and the lower concentration of cryoprotectant used.
Hemispherically Aggregated BaTiO<sub>3</sub> Nanoparticle Composite Thin Film for High-Performance Flexible Piezoelectric Nanogenerator (2014)

We report high-performance flexible nanogenerators (NGs) based on a composite thin film, composed of hemispherically aggregated BaTiO3 nanoparticles (NPs) and poly(vinylidene fluoride-co-hexafluoropropene) P(VDF-HFP). The hemispherical BTO-P(VDF-HFP) clusters were realized by a solvent evaporation method, which greatly enhanced piezoelectric power generation. The flexible NGs exhibit high electrical output up to ∼75 V and ∼15 μA at the applied force normal to the surface, indicating the important role of hemispherical BTO clusters. Besides, the durability and reproducibility of the NGs were tested by cyclic measurement under bending stage, generating the output of ∼5 V and ∼750 nA. The approach we introduce here is simple, cost-effective, and well-suited for large-scale high-performance flexible NG fabrication.
Isolation of Foreign Material-Free Endothelial Progenitor Cells Using CD31 Aptamer and Therapeutic Application for Ischemic Injury (2015)

Endothelial progenitor cells (EPCs) can be isolated from human bone marrow or peripheral blood and reportedly contribute to neovascularization. Aptamers are 40-120-mer nucleotides that bind to a specific target molecule, as antibodies do. To utilize apatmers for isolation of EPCs, in the present study, we successfully generated aptamers that recognize human CD31, an endothelial cell marker. CD31 aptamers bound to human umbilical cord blood-derived EPCs and showed specific interaction with human CD31, but not with mouse CD31. However, CD31 aptamers showed non-specific interaction with CD31-negative 293FT cells and addition of polyanionic competitor dextran sulfate eliminated non-specific interaction without affecting cell viability. From the mixture of EPCs and 293FT cells, CD31 aptamers successfully isolated EPCs with 97.6% purity and 94.2% yield, comparable to those from antibody isolation. In addition, isolated EPCs were decoupled from CD31 aptamers with a brief treatment of high concentration dextran sulfate. EPCs isolated with CD31 aptamers and subsequently decoupled from CD31 aptamers were functional and enhanced the restoration of blood flow when transplanted into a murine hindlimb ischemia model. In this study, we demonstrated isolation of foreign material-free EPCs, which can be utilized as a universal protocol in preparation of cells for therapeutic transplantation.