gebhart/patrepeval huggingface dataset:
Chromium(VI) forms a thiolate complex with glutathione (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromium(VI) forms a thiolate complex with glutathioneSamuel L. Brauer and Karen E. WetterhahnCite this: J. Am. Chem. Soc. 1991, 113, 8, 3001–3007Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ja00008a031https://doi.org/10.1021/ja00008a031research-articleACS PublicationsRequest reuse permissionsArticle Views469Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA (2017)

We demonstrate that the CRISPRa SAM system can be easily adopted and used to efficiently manipulate gene expression in pre- and mature adipocytes in vitro. Moreover, we describe a novel methodological approach combining the activation of endogenous genes and siRNA-mediated gene silencing, thus providing a powerful tool to functionally decipher genetic factors controlling adipogenesis and adipocyte functions.
Improved Low Reflection Transition From Microstrip Line to Empty Substrate-Integrated Waveguide (2017)

Substrate-integrated waveguides (SIWs) maintain the advantages of planar circuits (low loss, low profile, easy manufacturing, and integration in a planar circuit board) and improve the quality factor of filter resonators. Empty substrate-integrated waveguides (ESIWs) substantially reduce the insertion losses, because waves propagate through air instead of a lossy dielectric. The first ESIW used a simple tapering transition that cannot be used for thin substrates. A new transition has recently been proposed, which includes a taper also in the microstrip line, not only inside the ESIW, and so it can be used for all substrates, although measured return losses are only 13 dB. In this letter, the cited transition is improved by placing via holes that prevent undesired radiation, as well as two holes that help to ensure good accuracy in the mechanization of the input iris, thus allowing very good return losses (over 20 dB) in the measured results. A design procedure that allows the successful design of the proposed new transition is also provided. A back-to-back configuration of the improved new transition has been successfully manufactured and measured.
Solar Hydrogen Generation from Ambient Humidity Using Functionalized Porous Photoanodes (2019)

Solar hydrogen is a promising sustainable energy vector, and steady progress has been made in the development of photoelectrochemical (PEC) cells. Most research in this field has focused on using acidic or alkaline liquid electrolytes for ionic transfer. However, the performance is limited by (i) scattering of light and blocking of catalytic sites by gas bubbles and (ii) mass transport limitations. An attractive alternative to a liquid water feedstock is to use the water vapor present as humidity in ambient air, which has been demonstrated to mitigate the above problems and can expand the geographical range where these devices can be utilized. Here, we show how the functionalization of porous TiO<sub>2</sub> and WO<sub>3</sub> photoanodes with solid electrolytes-proton conducting Aquivion and Nafion ionomers-enables the capture of water from ambient air and allows subsequent PEC hydrogen production. The optimization strategy of photoanode functionalization was examined through testing the effect of ionomer loading and the ionomer composition. Optimized functionalized photoanodes operating at 60% relative humidity (RH) and <i>T</i><sub>cell</sub> = 30-70 °C were able to recover up to 90% of the performance obtained at 1.23 V versus reverse hydrogen electrode (RHE) when water is introduced in the liquid phase (i.e., conventional PEC operation). Full performance recovery is achieved at a higher applied potential. In addition, long-term experiments have shown remarkable stability at 60% RH for 64 h of cycling (8 h continuous illumination-8 h dark), demonstrating that the concept can be applicable outdoors.
Knowledge base views (2008)

The paper introduces an extension to the NeeK language [2, 5]. In the current shape NeeK allows for selection of fragments of a given ontology. The selected part is automatically mapped to a database schema by data views implementation [7]. Experience with a real system using data views has shown that the resulting database schema does not necessarily reflect the needs of the business logic of an application that uses a specific data view. As a work around database views were used on top of data views to modify the schema. Analogous experience with object views, an ontology-object mapping similar to object-relational mappings like Java Persistence API [1], has shown that straight forward mapping of a given ontology is not always sufficient. The modification of NeeK language proposed in the paper allows for minimizing the need of using database views for data views and additional code for of object views. This extension can be seen as a special case of ontology mapping, but focuses on solving particular problems of NeeK rather than being a complete ontology mapping language.
Co-design tool construction using APICES (1999)

Article Free Access Share on Co-design tool construction using APICES Author: Ansgar Bredenfeld Institute for Autonomous Intelligent Systems (AiS), Sankt Augustin, Germany Institute for Autonomous Intelligent Systems (AiS), Sankt Augustin, GermanyView Profile Authors Info & Claims CODES '99: Proceedings of the seventh international workshop on Hardware/software codesignMarch 1999 Pages 126–130https://doi.org/10.1145/301177.301506Published:01 March 1999Publication History 8citation168DownloadsMetricsTotal Citations8Total Downloads168Last 12 Months8Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A cryptographic primitive based authentication scheme for run-time software of embedded systems (2010)

Ensuring integrity of run time software of the safety and safety related embedded systems used for protection, control and monitoring of nuclear power plants is an important issue. In this paper, we discuss the scheme being implemented on the in-house developed CPU board, to check integrity of run time software using cryptographic primitive. Our scheme uses off-line SHA-1 (Secure Hash Algorithm) software implementation running on CPU of the in-house board and a hardware implementation of the same algorithm on a dedicated FPGA(Field Programmable Gate Array) of the same board. This paper discusses the details of the design, issues with respect to the device resources and performance parameters.
3 Role of Solution Conductivity in Reaction Induced Charge Auto-Electrophoresis (2016)

Catalytic bimetallic Janus particles swim by a bipolar electrochemical propulsion mechanism that results from electroosmotic fluid slip around the particle surface. The flow is driven by electrical body forces which are generated from a coupling of a reaction-induced electric field and net charge in the diffuse layer surrounding the particle. This paper presents simulations, scaling, and physical descriptions of the experimentally observed trend that the swimming speed decays rapidly with increasing solution conductivity. The simulations solve the full Poisson-Nernst-Planck-Stokes equations with multiple ionic species, a cylindrical particle in an infinite fluid, and nonlinear Butler-Volmer boundary conditions to represent the electrochemical surface reactions. The speed of bimetallic particles is reduced in high-conductivity solutions because of reductions in the induced electric field in the diffuse layer near the rod, the total reaction rate, and the magnitude of the rod zeta potential. The results in this work suggest that the auto-electrophoretic mechanism is inherently susceptible to speed reductions in higher ionic strength solutions.
Integrin Regulated Autoimmune Disorders: Understanding the Role of Mechanical Force in Autoimmunity (2022)

The pathophysiology of autoimmune disorders is multifactorial, where immune cell migration, adhesion, and lymphocyte activation play crucial roles in its progression. These immune processes are majorly regulated by adhesion molecules at cell-extracellular matrix (ECM) and cell-cell junctions. Integrin, a transmembrane focal adhesion protein, plays an indispensable role in these immune cell mechanisms. Notably, integrin is regulated by mechanical force and exhibit bidirectional force transmission from both the ECM and cytosol, regulating the immune processes. Recently, integrin mechanosensitivity has been reported in different immune cell processes; however, the underlying mechanics of these integrin-mediated mechanical processes in autoimmunity still remains elusive. In this review, we have discussed how integrin-mediated mechanotransduction could be a linchpin factor in the causation and progression of autoimmune disorders. We have provided an insight into how tissue stiffness exhibits a positive correlation with the autoimmune diseases' prevalence. This provides a plausible connection between mechanical load and autoimmunity. Overall, gaining insight into the role of mechanical force in diverse immune cell processes and their dysregulation during autoimmune disorders will open a new horizon to understand this physiological anomaly.
Lanthanum halide nanoparticle scintillators for nuclear radiation detection (2013)

Nanoparticles with sizes &lt;10 nm were fabricated and characterized for their nanocomposite radiation detector properties. This work investigated the properties of several nanostructured radiation scintillators, in order to determine the viability of using scintillators employing nanostructured lanthanum trifluoride. Preliminary results of this investigation are consistent with the idea that these materials have an intrinsic response to nuclear radiation that may be correlated to the energy of the incident radiation.
Digital circuit testing and testability (1997)

Faults in Digital Circuits: Failures and Faults. Modeling of Faults. Temporary Faults. Test Generation for Combinational Logic Circuits: Fault Diagnosis of Digital Circuits. Test Generation Techniques for Combinatorial Circuits. Multiple Fault Detection in Combinational Logic Circuits. Testable Combinational Logic Circuit Design: The Reed-Muller Expansion Technique. Three Level OR-AND-OR Design. Automatic Synthesis of Testable Logic. Testable Design of Multi-Level Combinational Circuits. Synthesis of Random Pattern Testable Combinational Circuits. Path Delay Fault Testable Combinational Logic Design. Testable PLA Design. Test Generation for Sequential Circuits: Testing of Sequential Circuits as IterativeCombinational Circuits. State Table Verification. Test Generation Based on Circuit Structure. Functional Fault Models. Test Generation Based on Functional Fault Models. Design of Testable Sequential Circuits: Controllability and Observability. Ad hoc Design Rules for Improving Testability. Design of Diagnosable Sequential Circuits. The Scan-Path Technique for Testable Sequential Circuit Design. Level-Sensitive Scan Design (LSSD). Random Access Scan Technique. Partial Scan. Testable Sequential Circuit Design Using Non-Scan Techniques. Cross Check. Boundary Scan. Built-In Self Test: Test Pattern for BIST. Output Response Analysis. Circular BIST. BIST Architecture. Testable Memory Design: RAM Fault Models. Test Algorithms for RAMs. Detection of Pattern Sensitive Faults. BIST Techniques for RAM Chips. Test Generation and BIST for Embedded RAMs. Subject Index.
Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes (2015)

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death. Gene therapy was established as a new strategy for treating HCC. To explore the potential delivery system to support the gene therapy of HCC, negatively charged liposomal delivery system was used to deliver miR-221 antisense oligonucleotide (anti-miR-221) to the transferrin (Tf) receptor over expressed HepG2 cells. The liposome exhibited a mean particle size of 122.5 nm, zeta potential of -15.74 mV, anti-miR-221 encapsulation efficiency of 70%, and excellent colloidal stability at 4°C. Anti-miR-221-encapsulated Tf-targeted liposome demonstrated a 15-fold higher delivery efficiency compared to nontargeted liposome in HepG2 cells in vitro. Anti-miR-221 Tf-targeted liposome effectively delivered anti-miR-221 to HepG2 cells, upregulated miR-221 target genes PTEN, P27(kip1), and TIMP3, and exhibited greater silencing efficiency over nontargeted anti-miR-221 liposome. After intravenous injection into HepG2 tumor-bearing xenografted mice with Cy3-labeled anti-miR-221 Tf-targeted liposome, Cy3-anti-miR-221 was successfully delivered to the tumor site and increased the expressions of PTEN, P27(kip1), and TIMP3. Our results demonstrate that the Tf-targeted negatively charged liposome could be a potential therapeutic modality in the gene therapy of human HCC.
Warfighting training R & D in the post cold war era: with a special emphasis on synthetic environments (1993)

Abstract : The article discusses warfighting training as an integral part of military missions and functions, and its impact on of the office of the Director for Research and Engineering's seven Scientific and Technology (S&T) Thrusts, i.e., Synthetic Environments, on future training strategies and technologies.
Adaptive Constraint Satisfaction (1996)

Many different approaches have been applied to constraint satisfaction. These range from complete backtracking algorithms to sophisticated distributed configurations. However, most research effort in the field of constraint satisfaction algorithms has concentrated on the use of a single algorithm for solving all problems. At the same time, a consensus appears to have developed to the effect that it is unlikely that any single algorithm is always the best choice for all classes of problem. In this paper we argue that an adaptive approach should play an important part in constraint satisfaction. This approach relaxes the commitment to using a single algorithm once search commences. As a result, we claim that it is possible to undertake a more focused approach to problem solving, allowing for the correction of bad algorithm choices and for capitalising on opportunities for gain by dynamically changing to more suitable candidates.
Reuse and upcycling of thermoset prepreg scrap: Case study with out-of-autoclave carbon fiber/epoxy prepreg (2017)

A large amount of uncured thermoset prepreg scrap is generated during manufacturing, including both ply cutter trim waste and out-of-spec material. While techniques to recycle end-of-life cured composite waste and reclaim carbon fiber are well established and commercialized, there is little effort made presently towards reusing uncured scrap prepreg. Here, we present a viable and scalable technique to process scrap prepreg into intermediate forms that can be readily manufactured into commercial end-products. Using out-of-autoclave carbon fiber/epoxy prepreg as an example, we report the mechanical properties, microstructure, and performance of composite laminates fabricated with scrap prepreg under various processing conditions. Demonstrator parts manufactured with scrap prepreg are also presented.
Cooperative disulfide bond formation in apamin (1992)

Apamin is being studied as a model for the folding mechanism of proteins whose structures are stabilized by disulfide bonds. Apamin consists of 18 amino acid residues and forms a stable structure consisting of a C-terminal alpha-helix and two reverse turns. This structure is stabilized by two disulfide bonds connecting Cys-1 to Cys-11 and Cys-3 to Cys-15. We used glutathione and dithiothreitol as reference thiols to measure the stabilities of the two disulfide bonds as a function of urea concentration and temperature in order to understand what contributes to the stability of the native structure. The results demonstrate modest contributions from secondary structure to the overall stability of the two disulfide bonds. The equilibrium constants for disulfide bond formation between the fully reduced peptide and the native structure with two disulfide bonds at 25 degrees C and pH 7.0 are 0.42 M2 using glutathione and 2.7 x 10(-5) using dithiothreitol. The equilibrium constant decreases by a factor of approximately 4 in 8 M urea and decreases by a factor of 3 between 0 and 60 degrees C. At least three one-disulfide intermediates are found at low concentrations in the equilibrium mixture. Using glutathione, the equilibrium constants for forming the one-disulfide intermediates with respect to the reduced peptide are approximately 0.025 M. The second disulfide bond forms with an equilibrium constant of approximately 17 M. Thus, apamin folding is very cooperative, but the native structure is only modestly stabilized by urea- or temperature-denaturable secondary structure.
Reaction-driven Ion Exchange of Copper into Zeolite SSZ-13 (2015)

We have used several techniques to characterize Cu-SSZ-13 before and after exposure to reaction conditions relevant for NO reduction by NH3–SCR to address the increase in NH3–SCR activity observed as a function of time on stream. Specifically, we focus on characterizing copper species in samples prepared with solid state ion exchange (SSIE) having varying Cu loadings from 0.7 to 5.2 wt %. X-ray diffraction shows that CuO species that likely remain from the SSIE synthesis on the outside of the zeolite crystallites are significantly reduced by exposure to reaction conditions. High-resolution X-ray diffraction (HR-XRD) further reveals a corresponding increase of Cu2O species. X-ray photoelectron, Auger electron, and ultraviolet–visible spectroscopy show an increase in both Cu(II) and Cu(I) species inside the zeolite pores, with a preserved long-range order of the zeolite structure as revealed by HR-XRD.
SUPERCRITICAL SOLVOTHERMAL SYNTHESIS AND NEAR-INFRARED ABSORBING PROPERTIES OF <font>Cs</font><sub>x</sub><font>WO</font><sub>3</sub> (2012)

Cs x WO 3 nanoparticles in the range of 20–50 nm have been successfully synthesized by the supercritical solvothermal approach, where after dissolving WCl 6 and CsOH in a mixed solution of water, ethanol and oleic acid, the solution was heated at 300°C. The products were characterized by X-ray diffraction, TEM, HR-TEM, EDS, laser particle size analysis and thermographic measurements. Cs x WO 3 nanoparticles showed the high transparency in the visible region, excellent shielding performance of the near-infrared light and limited reflectance of light in the range of 200–2700 nm, indicating the strong absorption of NIR light on the nanosized Cs x WO 3 . Cs x WO 3 nanoparticles also exhibited quick conversion of photo-energy to local heat.
Advances in interactive digital multimedia systems (1991)

This paper introduces basic concepts in digital multimedia systems and surveys recent literature. Background is provided regarding developments in interactive videodiscs, which first made images and video accessible through computer systems. Digital storage media, including optical, magnetic, and network options, are addressed. The characteristics of audio and video and their digital representations are discussed. Because these media are so demanding of space and channel bandwidth, compression methods are reviewed. Standards for digital multimedia are considered. Current multimedia systems are described, and future prospects are indicated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Black-White Differences in Serum Sex Hormones and Bone Mineral Density (1994)

To determine if differences in serum sex hormones contribute to racial differences in bone mass, independent of obesity, the authors compared bone mass and sex steroid hormone levels in 273 white women and 86 black women aged 65 years or older. This study was ancillary to the Study of Osteoporotic Fractures. Black women were recruited at two clinical centers in Baltimore, Maryland, and the Monongahela Valley, near Pittsburgh, Pennsylvania. An age-stratified random sample of white women was chosen from the Pittsburgh clinic. Demographic and historical information and anthropometric measurements were obtained from a clinic questionnaire, interview, and examination. Single photon absorptiometry was obtained at three sites: the distal radius, the proximal radius, and the calcaneus. Serum estrone, androstenedione, and testosterone were measured using extraction, column chromatography, and radioimmunoassay. Serum estrone concentrations were significantly higher and androstenedione levels were significantly lower in black women compared with white women. Racial differences in estrone could be explained largely by differences in the degree of obesity. Bone mass was greater in black women compared with white women within age, body mass index, (kg/m2), and estrone strata. Androgens were not related to bone mass. Within each race, bone mass increased linearly with increasing concentration of serum estrone. There was no interaction between race and serum estrone on bone mass. Each factor contributed independently and significantly to the regression model predicting bone mass. There was no attenuation of the effect of race if estrone was included in the model. In conclusion, race and serum estrone were independent determinants of bone mass.
Learning Dynamic Generator Model by Alternating Back-Propagation through Time (2019)

This paper studies the dynamic generator model for spatialtemporal processes such as dynamic textures and action sequences in video data. In this model, each time frame of the video sequence is generated by a generator model, which is a non-linear transformation of a latent state vector, where the non-linear transformation is parametrized by a top-down neural network. The sequence of latent state vectors follows a non-linear auto-regressive model, where the state vector of the next frame is a non-linear transformation of the state vector of the current frame as well as an independent noise vector that provides randomness in the transition. The non-linear transformation of this transition model can be parametrized by a feedforward neural network. We show that this model can be learned by an alternating back-propagation through time algorithm that iteratively samples the noise vectors and updates the parameters in the transition model and the generator model. We show that our training method can learn realistic models for dynamic textures and action patterns.