gebhart/patrepeval huggingface dataset:
New Approaches to the Development of Live Attenuated Rabies Vaccines (2002)

In the United States, extensive reservoirs of the rabies virus exist in many diverse wild animal species, which continue to pose a serious risk of lethal infection of humans and cause an economic burden exceeding $1 billion annually. Previous experience with rabies control in foxes in Europe has clearly demonstrated that oral immunization with live vaccines is the only practical approach to eradicate rabies in free-ranging animals. However, unlike Europe where vulpine rabies was the only major reservoir, the Americas harbor a variety of species including raccoons, skunks, coyotes, and bats that serve as the primary reservoirs of rabies. Each of these animal reservoirs carries an antigenically distinct virus variant. The currently available modified-live rabies virus vaccines have either safety problems or do not induce sufficient protective immunity in particular wildlife species. Therefore, there is a need for the development of new live rabies virus vaccines that are very safe and highly effective in particular wildlife species. Based on previous observations indicating that the potency of a vaccine is significantly increased if the G protein of the vaccine strain is identical to that of the target virus, we have used a reverse genetics approach to engineer viruses that contain G proteins from virus strains associated with relevant wildlife species. Furthermore, because our recent data also indicate that the pathogenicity of a particular rabies virus strain is inversely proportional to its ability to induce apoptosis and that low-level apoptosis-inducing ability is associated with low anti-viral immune responses, we inserted genes encoding pro-apoptotic proteins to stimulate immunity or otherwise interfere with viral pathogenesis into these recombinant viruses to enhance their efficacy and safety.
The Reliability of Puff Topography and Subjective Responses During Ad lib Smoking of a Single Cigarette (2011)

Puff topography and subjective measures during the ad lib smoking of a single cigarette are highly reliable. Smoking responses during a single ad lib smoking session may be useful in identifying stable individual differences in smoking reinforcement and reward.
Immunohistochemistry for Pathologists: Protocols, Pitfalls, and Tips (2016)

Immunohistochemistry (IHC) is an important auxiliary method for pathologists in routine diagnostic work as well as in basic and clinical research including exploration of biomarkers, as IHC allows confirmation of target molecule expressions in the context of microenvironment. Although there has been a considerable progress in automation and standardization of IHC, there are still many things to be considered in proper optimization and appropriate interpretation. In this review, we aim to provide possible pitfalls and useful tips for practicing pathologists and residents in pathology training. First, general procedure of IHC is summarized, followed by pitfalls and tips in each step and a summary of troubleshooting. Second, ways to an accurate interpretation of IHC are discussed, with introduction to general quantification and analysis methods. This review is not intended to provide complete information on IHC, but to be used as a basic reference for practice and publication.
Taxonomic positioning of two biological control agents for plant diseases as Lysobacter enzymogenes based on phylogenetic analysis of 16S rDNA, fatty acid composition and phenotypic characteristics (2003)

Inclusion of N4-7 and C3 as strains of L. enzymogenes is among the first description of members of this genus as biocontrol agents of plant diseases. These results suggest that members of the Lysobacter group might provide a new source as plant-associated microbes that display biocontrol activity.
Megahertz linewidth from a 1.5 μm semiconductor laser with HeNe laser injection (1982)

The linewidth of a 1.5 μm semiconductor laser has been reduced from > 1 GHz to < 1.5 MHz by injection locking the laser to the low-power narrow-linewidth output from an HeNe laser operating at 1.523 μm. A collimated-beam power of 750 μW was obtained in the injection-locked semiconductor laser mode.
Iris recognition using histogram analysis (2005)

Iris recognition is perhaps the most accurate means of personnel identification due to the uniqueness of the patterns contained in each iris. Most commercial iris recognition systems use a patented algorithm based on two-dimensional Gabor wavelets developed by Daugman. This paper describes an alternate means to identify individuals using images of their iris. Here, we simplify the process by using preprocessed one-dimensional histograms. The methodology in forming these histograms, how they are used in enrollment and identification and performance in terms of false positives and false negatives are presented.
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma (2013)

Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were determined according to subgroup affiliation, demographics, and clinical, prognostic, and molecular features. Integrated genomics approaches were used to identify specific somatic copy number alterations in TERT promoter-mutated and wild-type tumors. Overall, TERT promoter mutations were identified in 21 % of medulloblastomas. Strikingly, the highest frequencies of TERT mutations were observed in SHH (83 %; 55/66) and WNT (31 %; 4/13) medulloblastomas derived from adult patients. Group 3 and Group 4 harbored this alteration in <5 % of cases and showed no association with increased patient age. The prognostic implications of these mutations were highly subgroup-specific. TERT mutations identified a subset with good and poor prognosis in SHH and Group 4 tumors, respectively. Monosomy 6 was mostly restricted to WNT tumors without TERT mutations. Hallmark SHH focal copy number aberrations and chromosome 10q deletion were mutually exclusive with TERT mutations within SHH tumors. TERT promoter mutations are the most common recurrent somatic point mutation in medulloblastoma, and are very highly enriched in adult SHH and WNT tumors. TERT mutations define a subset of SHH medulloblastoma with distinct demographics, cytogenetics, and outcomes.
Application of Accident Prediction Models for Computation of Accident Risk on Transportation Networks (2002)

Accident risk has been applied extensively in transportation safety analysis. Risk is often used to describe the level of safety in transportation systems by incorporating a measure of exposure, such as traffic flow or kilometers driven. The most commonly applied definition of accident risk states that risk is a linear function of accidents and traffic flow. This definition, however, creates problems for transportation systems that are characterized by a nonlinear relationship between these variables. The primary objective of the original research was to illustrate the application of accident prediction models (APMs) to estimate accident risk on transportation networks. (APMs are useful tools for establishing the proper relationship between accidents and traffic flow.) The secondary objective was to describe important issues and limitations surrounding the application of APMs for this purpose. To accomplish these objectives, APMs were applied to a computerized transportation network with the help of EMME/2. The accident risk was computed with the traffic flow output of the computer program. The results were dramatic and unexpected: in essence, the individual risk of being involved in a collision decreases as traffic flow increases. The current and most common model form of APMs explains this outcome. The application of these results may have significant effects on transportation policy and intelligent transportation system strategies.
A VLSI implementation of the VAX vector architecture (2002)

A single-board implementation of the VAX vector architecture is described. The vector processor can be divided into three separate function units: the vector controller, implemented as a single chip; the arithmetic pipelines, implemented by four pairs of chips; and the load/store unit, implemented by one chip. In addition, the load/store chip controls a 1-MB cache. All three function units can operate independently. The vector coprocessor is designed for use in the VAX 6000 model 400 system. It was implemented using 1.5- mu m custom CMOS and LSI logics sea-of-gates gate array. Peak performance is 90 MFLOPS single precision and 45 MFLOPS double precision. The vector coprocessor achieves speedups between 3 and 40 times the scalar CPU across a range of benchmarks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
여성 새터민의 자녀 돌봄과 일: 실태와 지원방안 (2009)

여성 새터민들의 입국이 남성에 비해 급증하게 되면서, 이들에 대한 성인지적 관점에서의 지원이 요구되고 있다. 본 글에서 특히 관심을 갖는 부분은 여성 새터민들이 자녀돌봄 문제로 노동시장 진입이 남성에 비해 제약될 수 있다는 점이다. 여성 새터민들은 남성과 달이 탈북 후 제2국에서 장기간 체류하면서 결혼, 출산 과정을 거치게 되는 경우가 많이 나타나고 있으며, 남한 입국 이후 또 다시 자녀를 출산한 경우 이중, 삼중의 자녀 부양과 돌봄에 대한 책임을 안게 되는 것을 볼 수 있다. 또한, 여성 새터민들이 단독 입국 내지는 배우자 없이 자녀와 입국 하는 비율이 최근 들어 늘어나면서, 이들의 경우 부모나 친지 등의 가족 관계를 통해 자녀 양육 문제를 해결할 수 없는 상황이다. 따라서, 신뢰할 만한 공적 자녀 돌봄 지원 서비스가 뒷받침 되지 않을 경우 노동시장 진입이 제약될 수밖에 없는 상황이다. 이상과 같은 상황으로 여성 새터민, 특히 모자가정의 빈곤화 가능성을 간과할 수 없으며, 이는 나아가 새터민 가족 갈등과 해체, 빈곤의 세대 전이로 이어질 수 있다는 점에서 관심을 기울여야 할 부분이다. 본 글은 이러한 문제의식을 토대로 여성 새터민들이 탈북 후 제2국 체류 중 형성된모-자 관계로 인한 돌봄 문제와 남한 입국 이후 자녀 돌봄이 직업훈련과 취업, 직장생활 유지에 어떠한 영향을 미치고 있는 가를 선행 연구의 통계 자료를토대로 분석하고, 이들의 노동시장 진입을 위한 취업 지원 방안을 제시하고자 한다.
Exploring learner acceptance of the use of virtual reality in medical education: a case study of desktop and projection-based display systems (2013)

Advanced technologies have been widely applied in medical education, including human-patient simulators, immersive virtual reality Cave Automatic Virtual Environment systems, and video conferencing. Evaluating learner acceptance of such virtual reality (VR) learning environments is a critical issue for ensuring that such technologies are used to greatest effect. This research describes the use of high performance real-time interactive software (VR4MAX) to build a prototype 3D VR learning system. A questionnaire survey was distributed to 167 university students to investigate learner attitudes toward learning via VR applications. Experimental results show that immersion and imagination features of VR-mediated course contents have a positive impact on perceived usefulness, and can also predict perceived ease of use, both of which contributors to behavioral intention of learners to use VR learning systems. Overall, this research validates the relationship between three features of VR and learners' behavioral intention to use VR learning. The results could prove helpful in guiding future research related to VR learning.
Oxyfunctionalization of aliphatic compounds by a recombinant peroxygenase from <i>Coprinopsis cinerea</i> (2013)

The goal of this study is the selective oxyfunctionalization of aliphatic compounds under mild and environmentally friendly conditions using a low-cost enzymatic biocatalyst. This could be possible taking advantage from a new peroxidase type that catalyzes monooxygenase reactions with H2 O2 as the only cosubstrate (peroxygenase). With this purpose, recombinant peroxygenase, from gene mining in the sequenced genome of Coprinopsis cinerea and heterologous expression using an industrial fungal host, is tested for the first time on aliphatic substrates. The reaction on free and esterified fatty acids and alcohols, and long-chain alkanes was followed by gas chromatography, and the different reaction products were identified by mass spectrometry. Regioselective hydroxylation of saturated/unsaturated fatty acids was observed at the ω-1 and ω-2 positions (only at the ω-2 position in myristoleic acid). Alkyl esters of fatty acids and monoglycerides were also ω-1 or ω-2 hydroxylated, but di- and tri-glycerides were not modified. Fatty alcohols yielded hydroxy derivatives at the ω-1 or ω-2 positions (diols) but also fatty acids and their hydroxy derivatives. Interestingly, the peroxygenase was able to oxyfunctionalize alkanes giving, in addition to alcohols at positions 2 or 3, dihydroxylated derivatives at both sides of the molecule. The predominance of mono- or di-hydroxylated derivatives seems related to the higher or lower proportion of acetone, respectively, in the reaction medium. The recombinant C. cinerea peroxygenase appears as a promising biocatalyst for alkane activation and production of aliphatic oxygenated derivatives, with better properties than the previously reported peroxygenase from Agrocybe aegerita, and advantages related to its recombinant nature for enzyme engineering and industrial production.
The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina. (2000)

International audience
Oral fluid based biomarkers in periodontal disease: part 1. Saliva. (2014)

Traditional clinical measurements such as probing pocket depth, bleeding on probing, clinical attachment loss; plaque index and radiographs used for periodontal diagnosis are often of limited usefulness as they are indicators of previous periodontal disease rather than present disease activity. A literature search was carried out to find out all the available tests that indicate periodontal disease markers in saliva. All major databases were searched to compile the information on published reports between 1999 and 2014. The list of biomarkers available to date is compiled and presented in a table format. Each biomarker is discussed separately based on the available evidence. Based on the evidence, it can be concluded that several sensitive salivary indicators of periodontitis are available to detect the presence, severity and response to treatment. Further studies are warranted to analyze the sensitivity and reliability of these indicators that might help in developing non-invasive tests that could help in the diagnosis of periodontal disease.
Analysis of asymmetric out-of-band overshoot in narrowband active noise control systems (1999)

This work presents an analysis of a narrowband active noise control (ANC) system using the filtered-X least mean-square (LMS) algorithm. The origin and characteristics of asymmetric out-of-band overshoot are investigated. A perturbation technique is used to quantify the pole displacements of the system transfer function due to the secondary path delay.
MALURLs: Malicious URLs Classification System (2011)

Our mission is to be a premier Centre of Excellence by offering strategic management consulting services, a global forum for innovation, training and certifications, publication and collaboration at both regional and international levels through and by the effort of recognizing outstanding scholarly and professional contributions of both individuals and organizations.
EXAFS studies of rhodium- and rhodium-chromium-NaY zeolite catalysts: evidence for direct bonding between metal particles and anchoring ions (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEXAFS studies of rhodium- and rhodium-chromium-NaY zeolite catalysts: evidence for direct bonding between metal particles and anchoring ionsM. S. Tzou, B. K. Teo, and W. M. H. SachtlerCite this: Langmuir 1986, 2, 6, 773–776Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/la00072a018https://doi.org/10.1021/la00072a018research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Subsalt imaging with converted waves (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2000Subsalt imaging with converted wavesAuthors: Dimitri BevcVictor PereyraAlexander M. PopoviciDimitri Bevc3DGeo Development Inc., Victor PereyraWeidlinger Associates, and Alexander M. Popovici3DGeo Development Inc.https://doi.org/10.1190/1.1816098 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1816098FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2000ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION Dimitri Bevc, Victor Pereyra, and Alexander M. Popovici, (2000), "Subsalt imaging with converted waves," SEG Technical Program Expanded Abstracts : 469-472. https://doi.org/10.1190/1.1816098 Plain-Language Summary PDF DownloadLoading ...
Compact multiband planar antenna for mobile wireless terminals (2002)

A compact multiband planar antenna has been developed for mobile wireless terminals. This planar antenna, fabricated on rigid or flexible dielectric substrates, is capable of the multiband operation that is required in mobile wireless terminals such as telephones and personal digital assistants (PDAs). Multi-band operation is obtained by perturbing the shape of a conventional microstrip patch antenna in a prescribed manner. This highly reliable, low cost antenna offers a low profile with no moving parts and is ideally suited for installation within the terminal with no need for external parts. This paper presents the design, FM analysis and a complete set of measurements for the compact multiband antenna.
Switchable Ni–Mn–Ga Heusler nanocrystals (2008)

We examined bulklike Heusler nanocrystals using real-space pseudopotentials constructed within density functional theory. The nanocrystals were made of various compositions of Ni–Mn–Ga in the size range from 15 up to 169 atoms. Among these compositions, the closest to the stoichiometric Ni2MnGa were found to be the most stable. The Ni-based nanocrystals retained a tendency for tetragonal distortion, which is inherited from the bulk properties. Surface effects suppress the tetragonal structure in the smaller Ni-based nanocrystals, while bigger nanocrystals develop a bulklike tetragonal distortion. We suggest the possibility of switchable Ni–Mn–Ga nanocrystals, which could be utilized for magnetic nanoshape-memory applications.
Characterizing an Amorphous System Exhibiting Trace Crystallinity: A Case Study with Saquinavir (2007)

In this study, the ability of different analytical techniques to detect and characterize trace crystallinity in amorphous saquinavir was compared and the same techniques were used to investigate differences in the amorphous material before and after removal of the trace crystallinity by milling or heating. Saquinavir samples were analyzed for trace crystallinity and differences in the amorphous state by X-ray powder diffraction in combination with pair distribution function transforms, differential scanning calorimetry, modulated temperature differential scanning calorimetry, polarizing light microscopy, scanning electron microscopy, as well as Raman, near-infrared, and mid-infrared spectroscopy combined with multivariate analysis. X-ray powder diffraction and polarizing light microscopy were best suited to detecting small amounts of residual crystallinity and showed that these can easily be removed by heating or milling. Thermal analysis confirmed structural differences between amorphous saquinavir containing trace crystallinity and the milled and heated samples. Pair distribution function transforms of the X-ray powder diffraction data and the spectroscopic techniques in combination with multivariate analysis revealed differences in short-range and long-range order of the different samples. Raman spectroscopy was the most sensitive spectroscopic technique to detect structural changes induced by milling and heating saquinavir. Overall, the results suggest that the amorphous forms differ in their degree of disorder and molecular bonding arrangements. The study shows that significant insight into trace crystallinity and short-range order in amorphous material can be obtained by using a variety of physical characterization methods and data analysis techniques.
Supracondylar Fractures Following Total Knee Arthroplasty (1999)

Supracondylar fracture of the femur above a total knee arthroplasty (TKA) presents a challenging problem to orthopedic surgeons. Closed treatment has been associated with malunion, nonunion and loss of motion whereas early oper-
ative treatment has been associated with infection as well as nonunion. From1985 to 1996, 10 patients with ipsilateral supracondylar fracture of the femur after TKA were open reduction and internal fixation with screws and plates and 
bone grafting. All of the fractures were joined uneventfully except for one case with malunion. There were no post-operative infectios. Using the knee society rating system, the average post-operative knee score for those patients was 75 and the average function score was 68, respectively. All of the femoral compo- nents were well fixed at last follow-up.We look at records of the patients who experienced supracondylar fracture ipsilaterally after TKA, and analyze the incidence, Predisposing factors, fracture pattern, treatment and result. The best results were achieved through open treatment and early rehabilitation, with improving aseptic techniques and new modalities of fixation.