gebhart/patrepeval huggingface dataset:
Modeling and simulation of asymmetric stripline for multichip module applications (1997)

Modeling and simulation of interconnect materials has become critical to the success of high performance ULSI, packaging, and multilayer schemes for multichip modules. Computer simulation of the characteristic impedance Z (Ohms), capacitance C (pF), working frequency f (MHz) of Al asymmetric stripline filled with anodic Al oxide with dielectric constants 4 and 6.6 for multilayer schemes in a hybrid multichip module were conducted. A RLC-model of the frequency of Al transmission lines was successfully used. Using conformal mapping, the functional dependence of the characteristic impedance and working frequency on the capacitance of the Al stripline filled by anodic Al oxide can be determined. The results are valid for high frequencies. To evaluate this model and characterize its performance with high speed electrical multichip module design, a test cell using a multilayer interconnect structure Al/anodic al oxide on an Al substrate was developed.
Smart Buildings and Demand Response (2011)

Advances in communications and control technology, the strengthening of the Internet, and the growing appreciation of the urgency to reduce demand side energy use are motivating the development of improvements in both energy efficiency and demand response (DR) systems in buildings. This paper provides a framework linking continuous energy management and continuous communications for automated demand response (Auto‐DR) in various times scales. We provide a set of concepts for monitoring and controls linked to standards and procedures such as Open Automation Demand Response Communication Standards (OpenADR). Basic building energy science and control issues in this approach begin with key building components, systems, end‐uses and whole building energy performance metrics. The paper presents a framework about when energy is used, levels of services by energy using systems, granularity of control, and speed of telemetry. DR, when defined as a discrete event, requires a different set of building service levels than daily operations. We provide examples of lessons from DR case studies and links to energy efficiency.
Elevated FDG Activity in the Spinal Cord and the Sciatic Nerves Due to Neuropathy (2009)

A 78-year-old man presented with progressive difficulty walking, and changes in mental status. However, his brain magnetic resonance imaging was unremarkable. The possibility of paraneoplastic syndrome was raised, and an FDG-PET/CT of the body was performed to search for potential malignancy. Interestingly, there was diffusely increased FDG uptake along the lower spinal cord and sciatic nerves, which was subsequently confirmed to be due to neuropathy following nerve biopsy.
mGluR1‐β‐arrestin 2 Signaling Mediates Induction of Excitatory Synaptic Plasticity (2015)

A subset of seven‐transmembrane receptors (7TMRs) couple to both G protein‐ and β‐arrestin (βarr)‐mediated signaling pathways. Our objective is to determine if group I metabotropic glutamate receptors (mGluR1 and mGluR5) engage βarr signaling during the induction of synaptic plasticity in the CNS. In these experiments we tested the role of βarr‐Src‐MAPK signaling in the induction of plasticity at the hippocampal mossy fiber‐CA3 synapse. We compared mGluR1‐dependent synaptic plasticity in patch clamp recordings from CA3 pyramidal neurons in hippocampal slices prepared from wildtype, βarr 1 and βarr 2 knockout mice. Potentiation of EPSCs induced by low frequency, paired stimulation of mossy fiber inputs to CA3 pyramidal neurons was absent in mice lacking βarr 2 (91 ± 7% n=9 for βarr 2 ‐/‐ , 125 ± 9% n=18 for wildtype, p=0.01) but intact in mice lacking βarr 1 (128 ± 11% n=8 for βarr 1 ‐/‐ , 122 ± 13% n=17 for wildtype, p=0.74). In contrast, high‐frequency stimulation that induced long‐term potentiation was unaffected by gene targeting of either βarr isoform (190 ± 23% n=9 for βarr 1 ‐/‐ , 153 ± 18% n=6 for wildtype, p=0.22; 163 ± 18% n=7 for βarr 2 ‐/‐ , 167 ± 14% n=6 for wildtype, p=0.89). Pharmacological dissection implicated ERK1/2 of the MAPK pathway (104 ± 8% n=6 for u0126‐treated slices, 139 ± 9% n=15 for vehicle slices, p=0.01), whereas the role of Src tyrosine kinases was equivocal (114 ± 8% n=9 for PP2‐treated slices, 139 ± 9% n=15 for vehicle slices, p=0.06). These data reveal a novel signaling function for βarrs when coupled to mGluR1 and therefore yield insight into new strategies for therapeutic targeting of group I mGluRs, which in recent years has been pursued for a number of neuropathologies. Research supported by R21 NS088916‐01 from NINDS to GTS.
Antistaphylococcal Activities of Telavancin Tested Alone and in Combination by Time-Kill Assay (2010)

Synergy time-kill studies against 40 methicillin-resistant Staphylococcus aureus (MRSA) strains of differing resistance phenotypes were conducted. Subinhibitory concentrations of telavancin were combined with sub-MIC concentrations of other antimicrobial agents that might be used in combination with telavancin to provide Gram-negative coverage. The highest incidence of synergy was found after 24 h with gentamicin (90% of strains), followed by ceftriaxone (88%), rifampin and meropenem (each 65%), cefepime (45%), and ciprofloxacin (38%) for combinations tested at or below the intermediate breakpoint for each agent.
The dermal lymphatics in lymphoedema visualized by indirect lymphography (1984)

Iotasul, a new water-soluble contrast medium, is very suitable for subepidermal infusion (indirect lymphography) for the demonstration of small (initial) dermal lymphatics in the macro-range (precollectors). By this method normal lymph vessels can be demonstrated in the healthy skin of hands and feet which are so fine that they cannot be punctured for direct lymphography. We studied thirty-eight patients with various forms of lymphoedema by indirect lymphography. In patients with congenital lymphoedema (particularly Milroy's disease) the initial dermal lymphatics in the lymphoedematous region were absent but large lymph collectors were present. Hyperplasia of dermal lymphatics in the form of an extremely fine net was seen in most patients with lymphoedema praecox and tardum. In some forms of primary lymphoedema the defect may be in the initial dermal lymphatics. In secondary lymphoedema, the changes in the peripheral lymphatics (mainly distension and congestion) are apparently a consequence of the primary lesion in the lymph nodes and large collectors. Indirect lymphography might be useful for the early diagnosis of mild lymphoedema and for excluding patients with hypoplasia of initial lymph vessels from surgery.
CLINICAL CORRELATES OF ACOUSTIC NEUROMA VOLUME (1993)

A computer-assisted, MRI-based technique of tumor volume determination was used to correlate preoperative hearing levels and long-term postoperative facial function with acoustic neuroma volume. Preoperative hearing was studied in a group of 41 patients subjected to direct tumor volume calculations and in another group of 131 patients in whom volume was extrapolated from the acoustic neuroma volume-diameter relation. Similarly postoperative facial function was correlated with acoustic neuroma volume in another 864 patients in whom long-term follow-up was available. Preoperative hearing levels were found not to be significantly related to tumor volume. However, postoperative facial function was significantly associated with tumor volume and was best predicted as a nonlinear function of diameter. Thus, tumor volume changes are important considerations in the clinical management of acoustic neuromas. Patients should be advised that even small changes in tumor diameter (especially in larger tumors) can result in tumor volume changes that may be associated with significant changes in postoperative facial function.
Inclined slot coupled hemispherical dielectric resonator antenna (2008)

Abstract A microstrip line coupled dielectric resonator antenna with an inclined and offset slot in the common ground plane has been analyzed. Excitation of the TE 111 mode in this configuration is studied. It is also seen that the slot geometry and offset can be optimized to excite the higher order TM 101 mode. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 1527–1530, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23414
Ku protein and DNA repair (2008)

Ionizing radiation can cause double strand break(DSB),Ku protein as a heterologous dimmer;mainly join in non-homologous end-joining repair pathway.Ku protein plays a crucial role in maintaining telomem structure.There is an abnormal expression of Ku protein in human different tumors.The expression and function of Ku protein is relate to resistance of tumor radiotherapy and chemotherapy.Inhibition of Ku protein can enhance the sensitivity of radiotherapy and chemotherapy.Therefore,Ku protein can be used as target of enhancement of radiotherapy and chemotherapy.

Key words: 
DNA repair; Radiation tolerance; Neoplasm
The ClpP serine protease is essential for the intracellular parasitism and virulence of <i>Listeria monocytogenes</i> (2000)

We identified the stress-induced ClpP of Listeria monocytogenes and demonstrated its crucial role in intracellular survival of this pathogen. ClpP is a 21.6 kDa protein belonging to a family of proteases highly conserved in prokaryotes and eukaryotes. A clpP-deleted mutant enabled us to demonstrate that ClpP is involved in proteolysis and is required for growth under stress conditions. Intramacrophage survival of this mutant was strongly restricted, thus resulting in loss of virulence for the mouse. The activity of listeriolysin O, a major virulence factor implicated in bacterial escape from phagosomes of macrophages, was much reduced in the clpP mutant under stress conditions. Direct evidence for the role of ClpP in the intracellular parasitism was obtained by showing that virulence and haemolytic activity were fully restored by complementation of the mutant. These results suggest that ClpP is involved in the rapid adaptive response of intracellular pathogens during the infectious process.
Synergetic Dispersion Effect of Graphene Nanohybrid on the Thermal Stability and Mechanical Properties of Ethylene Vinyl Acetate Copolymer Nanocomposite (2013)

This study provides a facile approach to improving the dispersion of graphene in polymer matrix through a synergetic effect between two kinds of two-dimensional (2D) nanofillers. The nanohybrid based on graphene and boehmite (AlOOH) was synthesized by decorating AlOOH nanoplatelets on the graphene nanosheets. The graphene nanohybrid/ethylene vinyl acetate copolymer (EVA) nanocomposite showed a more homogeneous dispersion than those of composites containing only a single nanomaterial. The obtained nanocomposite exhibited significant enhancements in thermal stability and mechanical properties, compared with those of neat EVA and composites with only graphene or AlOOH. The temperature at 80 wt % degradation for the nanohybrid-based nanocomposite was increased by 27 °C in comparison with that of neat EVA. Nevertheless, only a 14 °C improvement and no enhancement were observed for the AlOOH- and graphene-based composites, respectively. Additionally, after the incorporation of nanohybrid in EVA, the tensile strength increased by 37.1%, from 12.4 to 17.0 MPa.
A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases (2011)

Histone methylations are important chromatin marks that regulate gene expression, genomic stability, DNA repair, and genomic imprinting. Histone demethylases are the most recent family of histone-modifying enzymes discovered. Here, we report the characterization of a small-molecule inhibitor of Jumonji C domain-containing histone demethylases. The inhibitor derives from a structure-based design and preferentially inhibits the subfamily of trimethyl lysine demethylases. Its methyl ester prodrug, methylstat, selectively inhibits Jumonji C domain-containing his-tone demethylases in cells and may be a useful small-molecule probe of chromatin and its role in epigenetics.
Characterization of hepatitis B virus surface antigen‐specific CD4+ T cells in hepatitis B vaccine non‐responders (2001)

The present results have also shown that at least four distinct HBsAg-reactive CD4+ clones existed (variable gene of T cell receptor beta (V beta) 17 + clone restricted with HLA-DR locus (DR4), V beta 8 + clone restricted with HLA-DQ locust (DQ7), and both V beta 5.1 + clone and V beta 20 + clone restricted with either DR9 or DQ3) in NRs. The results demonstrated that heterogeneous HBsAg-reactive CD4 clones existed in some HB vaccine NRs.
H3K9 acetylation and radial chromatin positioning (2009)

Histone variants and their epigenetic modifications determine genome function, particularly transcription. However, whether regulation of gene expression can be influenced by nuclear organization or vice versa is not completely clear. Here, we analyzed the effect of epigenetic changes induced by a histone deacetylase inhibitor (HDACi) on the nuclear radial rearrangement of select genomic regions and chromosomes. The HDACi, sodium butyrate (NaBt), induced differentiation of human adenocarcinoma HT29 cells as well as a genome-wide increase in H3K9 acetylation. Three-dimensional analysis of nuclear radial distributions revealed that this increase in H3K9 acetylation was often associated with a repositioning of select loci and chromosomes toward the nuclear center. On the other hand, many centromeres resided sites more toward the nuclear periphery, similar to sites occupied by chromosome X. In more than two-thirds of events analyzed, central nuclear positioning correlated with a high level of H3K9 acetylation, while more peripheral positioning within interphase nuclei correlated with a lower level of acetylation. This was observed for the gene-rich chromosomes 17 and 19, TP53, and CCND1 genes as well as for gene-poor chromosome 18, APC gene, regions of low transcriptional activity (anti-RIDGEs), and the relatively transcriptionally less active chromosome X. These results are consistent with a role for epigenetic histone modifications in governing the nuclear radial positioning of genomic regions during differentiation.
Review of strobilurin fungicide chemicals (2007)

Strobilurins are natural products isolated and identified from specific fungi. Natural strobilurins were named in the order of their discovery as strobilurin-A followed by strobilurin-B, C, D etc. Their discovery opened the door for new chemistry of synthetic fungicides. Applying Quantitative Structural Activity Relationship (QSAR) on the structures of the natural strobilurins, many pesticide companies were able to discover many synthetic analogues that are more efficacious and more stable fungicides. At present there are about eight synthetic strobilurins in the fungicides worldwide market. Some of these products are worldwide registered for use as agrochemical and some are in the process of registration. This class of fungicides is relatively new, as crop protection products and information about them is still fairly scarce. In this review, syntheses and chemistry of natural and synthetic strobilurins are discussed. Also, the mode of action, efficacy, biotic/abiotic degradation, analytical methods, and agricultural uses are discussed.
EVOLUTION THROUGH GROUP SELECTION (1988)

In this carefully argued book, Wynne-Edwards develops in further detail his hypothesis that intergroup selection has played an important role in evolution, His thesis, put forward 25 years ago in Animal Dispersion in Relation to Social Behavior, begins with the observation that some of the attributes of organisms cannot be convincingly accounted for by natural selection operating among individuals.In particular, the ecological finding that organisms rarely, if ever, overexploit their food resources is central to Wynne-Edwards' evolutionary arguments.His own research into
A low-noise instrumentation amplifier with DC suppression for recording ENG signals (2015)

This paper presents an AC-coupled instrumentation amplifier for electroneurogram (ENG) activity recording. For this design, we evaluate gain and noise requirements based on interference sources (electrodes, power line, EMG). The circuit has been implemented in a commercially-available 0.35μm CMOS technology with total power consumption 460μW. The amplifier achieves CMRR 107 dB and integrated input referred noise 940 nV. The gain is 63 dB and the bandwidth is 0.5 Hz- 13 kHz. The chosen topology enables to minimise on-chip capacitance (only 27 pF), with a total chip area of 0.4mm2.
Augmented Reality and Mobile Learning: the State of the Art. (2012)

In this paper, we examine the state of the art in augmented reality (AR) for mobile learning. Previous work in the field of mobile learning has included AR as a component of a wider toolkit but little has been done to discuss the phenomenon in detail or to examine in a balanced fashion its potential for learning, identifying both positive and negative aspects. We seek to provide a working definition of AR and to examine how it can be embedded within situated learning in outdoor settings. We classify it according to key aspects (device/technology, mode of interaction/learning design, type of media, personal or shared experiences, whether the experience is portable or static, and the learning activities/outcomes). We discuss the technical and pedagogical challenges presented by AR, before looking at ways in which it can be used for learning. Finally, the paper looks ahead to AR technologies that may be employed in the future.
Saccharification of Algae Biomass for Bioethanol Production (2010)

Carbohydrate content in algae is one of the present feedstock for bioethanol. The doubling time of microalgae could be range from 3.5 to 6 hours which is short time. Very fast growing microalgae with high content of carbohydrate is a potential feedstock which is renewable and environmental friendly. The present study is carried out for saccharification of Laminaria japonica and Spirulina platensis with acid hydrolysis which is essential to get fermentable sugars. Powder of Laminaria japonica was purchased from Jeon-Won Foods Co where as Spiruilina was cultivated in photobioreactor with spirulina medium, temperature 30℃, light 60~70μmol/m²·s and 0.7 vvm air was provided.The biomass was hydrolysis with sulfuric and hydrochloric acid concentration range from 1, 3, and 5% with temperature 110℃ and 12 0℃ for 30 and 60 minutes. The increase in acid concentration during acid hydrolysis did not significantly affect the total sugar and glucose concentration. In case of biomass higher biomass 1% result higher total sugar yield. In this study, pre-experiment is reported for the most efficient conditions of saccharification using acid hydrolysis for bioethanol production.
Peripheral blood and jejunal intraepithelial immune cell phenotypes associated with body weight of newly weaned pigs (81.9) (2009)

Abstract Early immune development has been purported to have ramifications on metabolic functions related to subsequent growth. To determine if specific immune cell populations were associated with pigs with heavy and light body weight (BW), piglets were weaned to an on-site conventional or a segregated weaning facility and immune cell phenotypes were characterized and correlated to piglet BW. Pig BW was measured and flow cytometry analyses were performed on PBMC and jejunal intraepithelial lymphocytes (IEL) on day 11, 18, and 25 after weaning. Ordination methods were performed to determine the relationship of specific immune cell phenotypes to piglet BW. Cell phenotypes consistent with γδ (CD4+γδ+CD8-, CD8+γδ+CD4-) and activated (CD25+) IEL were positively correlated to pig BW on day 11, whereas PBMC expressing MHC2 (MHC2+CD3-) resulted in a negative correlation. On day 18, CD25+CD8+CD4+ IEL were positively correlated and PBMC expressing CD8+CD4+ were negatively correlated to pig BW. CD25+ and CD4+CD8+ IEL populations were positively correlated to pig BW on day 25, whereas IEL γδ populations (γδ+CD8+CD4-, CD4+CD8+γδ+) and PBMC expressing MHC2 (MHC2+CD3-) were negatively correlated to BW. These data indicate that specific immune cell phenotypes correlate to pig BW after weaning. Specifically, IEL expressing CD25 are associated with pigs with heavier BW after weaning, whereas IEL expressing the γδ T cell receptor are associated with heavy BW pigs early after weaning but are correlated to low BW in older pigs.
Take Pride in America in Southern Nevada: Quarterly Progress Report, Period Ending December 31, 2005 (2005)

Messaging campaign proposal approved by the federal Land Managers. Invitations sent to potential Community Steering Committee members. Project Manager Doug Joslin appointed to new county-wide Southern Nevada Recycling Advisory Committee. Four public service announcements produced by UNLV students. Contract with the Nevada Division of Forestry (NDF) in progress for prison crew site clean-ups. Plan for agency requests for additional dumpsters and/or roll-offs approved by team.
Comparison of Horizontal and Vertical Unidirectional (Laminar) Air-flow Systems in Orthopedic Surgery (1977)

The microbiological evaluation of a horizontal walled unit, a horizontal wall-less unit and a vertical wall-less unidirectional airflow unit revealed a statistical reduction in the wound and back table air settle plate counts for the 2 horizontal systems as compared to the vertical system.
Progress on lead-free metal halide perovskites for photovoltaic applications: a review (2017)

Metal halide perovskites have revolutionized the field of solution-processable photovoltaics. Within just a few years, the power conversion efficiencies of perovskitebased solar cells have been improved significantly to over 20%, which makes them now already comparably efficient to silicon-based photovoltaics. This breakthrough in solution-based photovoltaics, however, has the drawback that these high efficiencies can only be obtained with leadbased perovskites and this will arguably be a substantial hurdle for various applications of perovskite-based photovoltaics and their acceptance in society, even though the amounts of lead in the solar cells are low. This fact opened up a new research field on lead-free metal halide perovskites, which is currently remarkably vivid. We took this as incentive to review this emerging research field and discuss possible alternative elements to replace lead in metal halide perovskites and the properties of the corresponding perovskite materials based on recent theoretical and experimental studies. Up to now, tin-based perovskites turned out to be most promising in terms of power conversion efficiency; however, also the toxicity of these tinbased perovskites is argued. In the focus of the research community are other elements as well including germanium, copper, antimony, or bismuth, and the corresponding perovskite compounds are already showing promising properties.
Exercise Is Medicine (1996)

In briefExercise is becoming more widely used to prevent and treat the diseases that are most prevalent in the United States: coronary artery disease, stroke, hypertension, diabetes, arthritis, osteoporosis, dyslipidemia, obesity, depression, cancer, and chronic obstructive pulmonary disease. However, physicians need more training in how to make best use of this powerful therapy. Physicians can successfully encourage activity by giving patients a written exercise prescription along with printed advice on how to design a safe, enjoyable routine.