gebhart/patrepeval huggingface dataset:
A routing model for the NCR GAPP (2003)

A routing model for the NCR Geometric Arithmetic Parallel Processor (GAPP) is described. The objective is to permit virtual reconfigurations of the array of processing elements (PEs) and nonlocal connections between arbitrarily distant PEs. The main feature of the model is the multiplexing of two instruction sets, over an additional pin, controlling either the SIMD (single-instruction, multiple-data-stream) machine or the set of router-cells organized as a hypercube network. A description is given of which structural changes are applied to the GAPP SIMD machine to support the routing scheme, and the operations concurrently executed by the router-cells for receiving, delivering or forwarding messages. A functional description of a semantic network which was designed expressly to test the routing model is given together with examples of its use.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Complete Idiot's Guide to Etiquette (1996)

This guide offers advice on everything from table manners to business etiquette. Included are tips for dealing with all kinds of social occasion including weddings, funerals and anniversaries. Advice is also provided on electronic etiquette, from voice mail and call waiting to beepers and e-mail.
Variation of the relaxographic “shutter‐speed” for transcytolemmal water exchange affects the CR bolus‐tracking curve shape (2003)

Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T(-1)) for the equilibrium transcytolemmal water exchange process increases. The quantity T(-1) is given by |r(1o)[CR(o)] + R(1o0) - R(1i)| (where r(1o) and [CR(o)] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R(1o0) and R(1i) are the extra- and intracellular (1)H(2)O relaxation rate constants, respectively, in the absence of exchange). The increase of T(-1) with [CR(o)] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO(Copyright )). The shutter-speed effect alters the shape of the bolus-tracking (B-T) time-course. It is shown that this is mostly accounted for by the inclusion of only one additional parameter, which measures the mean intracellular lifetime of a water molecule. Simulated and real data demonstrate that the effect of shutter-speed variation on pharmacokinetic parameters can be very significant: neglecting this effect can lead to an underestimation of the parameter values by 50%. This phenomenon can be heterogeneous. Within a tiny gliosarcoma implanted in the rat brain, the interstitial CR in the tumor core never rises to a level sufficient to cause apparent slowing of the exchange process. However, within the few microns needed to reach the proliferating rim, this occurs to a significant degree. Thus, even relative pharmacokinetic quantities can be incorrectly represented in a parametric map that neglects this effect. The BOLERO analysis shows promise for in vivo vascular phenotyping in pathophysiology. It also includes a provision for approximating the separation of the perfusion and permeability contributions to CR extravasation.
In vitro stimulatory effect of substance P on hematopoiesis (1993)

The neuropeptide Substance P (SP) is widely distributed in the peripheral nervous system. Its biologic effects have been extensively studied in the immune system. However, even though the bone marrow (BM) is innervated with SP-immunoreactive fibers and some of its cells not only express SP receptors (T and B cells, endothelial cells, and macrophages) but also produce SP (macrophages, eosinophils, and endothelial cells), the effects of SP on hematopoiesis are scanty. Furthermore, SP induces the production of hematopoietic growth factors (HGFs) (interleukin-1 [IL-1], IL-6, and tumor necrosis factor alpha) from human monocytes. In this study, we have found a potent in vitro stimulatory effect of SP (10(-8) to 10(-12) mol/L) on hematopoiesis for both erythroid and granulocytic progenitors in short-term methyl-cellulose BM cultures. SP alone, in the absence of exogenous HGFs, is able to sustain hematopoiesis in vitro. This stimulatory effect of SP is: (1) mostly mediated by the adherent cells; (2) completely abrogated by two SP receptor (SP-R) antagonists; and (3) partially reduced by anti-IL-1, IL-3, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF). Furthermore, it appears that the stimulatory effect of SP may be mediated by IL-3 and GM-CSF because we have also found that SP induces the release of these two cytokines from BM mononuclear cells. Considering that the SP effect occurs at concentrations as low as 10(-11) mol/L, and via a specific receptor, it appears that SP may play a physiologic role in regulating hematopoiesis, at least partially through the adherent BM cells and the release of HGFs, and may place SP, a neuropeptide, in a new category of hematopoietic regulators.
Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions (2017)

Claudin-6 (CLDN6) is an integral component of the tight junction proteins in polarized epithelial and endothelial cells and plays a crucial role in maintaining cell integrity. Deregulation of CLDN6 expression and distribution in tumor tissues have been widely documented and correlated with cancer progression and metastasis. However, a complete mechanistic understanding of CLDN6 regulation and function remains to be studied. Herein, we show new potential properties of CLDN6 regulation and functions from bioinformatics analysis. Using numerous algorithms to characterize the CLDN6 gene promoter elements and the CLDN6 protein structure, physio-chemical and localization properties, and its evolutionary relationships. CLDN6 is regulated by a diverse set of transcription factors (SP1, SPR, AML-1a, CdxA, CRE-BP and CREB) and associated with the levels of methylation of CpG islands in promoters. The structural properties of CLDN6 indicate that it promotes cancer cell behavior via the ASK1-p38/JNK MAPK secretory signaling pathway. In conclusion, this information from bioinformatics analysis will help future attempts to better understand CLDN6 regulation and functions.
Decrease of HIV-1 RNA levels in lymphoid tissue and peripheral blood during treatment with ritonavir, lamivudine and zidovudine (1998)

Treatment with this triple antiretroviral drug combination produced a durable and strong decrease of HIV-1 RNA burden in both plasma and lymphoid tissue.
Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment (2016)

CD40 is an interesting target in cancer immunotherapy due to its ability to stimulate T-helper 1 immunity via maturation of dendritic cells and to drive M2 to M1 macrophage differentiation. Pancreatic cancer has a high M2 content that has shown responsive to anti-CD40 agonist therapy and CD40 may thus be a suitable target for immune activation in these patients. In this study, a novel oncolytic adenovirus armed with a trimerized membrane-bound extracellular CD40L (TMZ-CD40L) was evaluated as a treatment of pancreatic cancer. Further, the CD40L mechanisms of action were elucidated in cancer models. The results demonstrated that the virus transferring TMZ-CD40L had oncolytic capacity in pancreatic cancer cells and could control tumor progression. TMZ-CD40L was a potent stimulator of human myeloid cells and T-cell responses. Further, CD40L-mediated stimulation increased tumor-infiltrating T cells in vivo, which may be due to a direct activation of endothelial cells to upregulate receptors for lymphocyte attachment and transmigration. In conclusion, CD40L-mediated gene therapy is an interesting concept for the treatment of tumors with high levels of M2 macrophages, such as pancreatic cancer, and an oncolytic virus as carrier of CD40L may further boost tumor killing and immune activation.
A microservice based reference architecture model in the context of enterprise architecture (2016)

In the service oriented, customer experience centric and customer changing demand driven market environment, ICT is becoming the leading enabler and partner of the modern enterprise business. More and more companies are transformed into more or pure digital style and virtual organized enterprises that are enabled and supported by a group of business oriented and microservice based applications and modules that are new to most of the companies and enterprises, both business and technical solution staff. This paper presents a microservice based reference architecture model with clear understanding and definition of the concept of microservice and key architectural components and building blocks for implementing and managing enterprise microservices in the context of enterprise architecture. This reference architecture model can be used as the pragmatic guidance for both business and IT professionals when they develop the enterprise IT transformation architecture solutions so that the API and microservice relevant technologies could be used properly at enterprise level without confusion. This paper also highlights a set of key architectural issues and provides corresponding recommendations when APIs and microsevices are leveraged within a company at enterprise level.
Why a <scp>d</scp>-β-hydroxybutyrate monoester? (2020)

Much of the world's prominent and burdensome chronic diseases, such as diabetes, Alzheimer's, and heart disease, are caused by impaired metabolism. By acting as both an efficient fuel and a powerful signalling molecule, the natural ketone body, d-β-hydroxybutyrate (βHB), may help circumvent the metabolic malfunctions that aggravate some diseases. Historically, dietary interventions that elevate βHB production by the liver, such as high-fat diets and partial starvation, have been used to treat chronic disease with varying degrees of success, owing to the potential downsides of such diets. The recent development of an ingestible βHB monoester provides a new tool to quickly and accurately raise blood ketone concentration, opening a myriad of potential health applications. The βHB monoester is a salt-free βHB precursor that yields only the biologically active d-isoform of the metabolite, the pharmacokinetics of which have been studied, as has safety for human consumption in athletes and healthy volunteers. This review describes fundamental concepts of endogenous and exogenous ketone body metabolism, the differences between the βHB monoester and other exogenous ketones and summarises the disease-specific biochemical and physiological rationales behind its clinical use in diabetes, neurodegenerative diseases, heart failure, sepsis related muscle atrophy, migraine, and epilepsy. We also address the limitations of using the βHB monoester as an adjunctive nutritional therapy and areas of uncertainty that could guide future research.
Laser-based sample preparation for electronic package failure analysis (2002)

Failure analysis has come to play a key role in ensuring quality and reliability in semiconductor devices, associated packaging and printed wiring boards. Tools are increasingly available to those investigating high-density integrated circuits at the die level, particularly for edit and repair operations. Until recently however, this capability has been limited by the inherent low-resolution mechanical/manual processes used for destructive analysis on electronics packaging. A laser-based tool has been developed to selectively and locally enable access to traces and layers within packages and provide a way to perform edits to an area of interest.
Enhanced Life Prediction Technology for Engine Rotor Life Extension (ERLE) (2008)

Abstract : The Air Force Research Laboratory (AFRL) conceived of the Engine Rotor Life Extension (ERLE) program as a sound science and technology investment that offers the potential for significant cost avoidance. The strategy for meeting this goal is to extend the life of certain life-limiting components, without increasing risk, by systematically improving, and more effectively integrating, a number of life management technologies -- life prediction, nondestructive inspection, engine health monitoring, maintenance, and repair. The current program has developed physics-based, deterministic and probabilistic, fatigue life prediction models that support the objectives of ERLE, as well as the broader goals of Condition Based Maintenance Plus (CBM+). The new models incorporate small crack effects and enable enhanced fracture mechanics analysis of high stress radients associated with residual contact and thermal stresses. The importance of uncertainty in mission usage is highlighted, and a statistical method to automatically identify mission type from usage data is introduced. Probabilistic simulations incorporating input from an embedded sensor model are used to demonstrate the effectiveness of engine health monitoring. Mature technology from the program has been incorporated into the DARWIN probabilistic life prediction code to facilitate technology transfer to AFRL and the turbine engine community.
Die Therapie des akuten ischämischen Insultes (1997)

Zusammenfassung Der ischämische Insult ist ähnlich dem Herzinfarkt ein akuter Notfall, der unmittelbarer Diagnostik, Behandlung und Überwachung bedarf. Hierzu sind adäquate personelle, apparative und logistische Voraussetzungen zu schaffen. Überwacht werden sollten neben dem neurologischen Verlauf Blutdruck, EKG, Atmung, Temperatur und möglichst auch O2-Sättigung. Der meist situativ erhöhte Blutdruck bei Aufnahme darf (außer bei Komplikationen wie Angina pectoris) nicht sofort, sondern erst nach 15-20 Minuten und nicht um mehr als 20% gesenkt werden. Interventionsgrenzwerte müssen individuell bestimmt werden. Hypotone Werte sollten durch Volumengabe und in Ausnahmefällen durch Vasopressiva bekämpft werden. Eine Hämodilution (Verminderung der Sauerstofftransportkapazität) ist nicht indiziert, wohl aber eine moderate Volumensubstitution. Der Wert der Fibrinolyse ist z. Zt. nicht gesichert. Antiaggreganzien verbessern wahrscheinlich die Prognose eines Insultes, gleiches gilt für niedrigdosiertes Heparin. Der Einsatz PTT-wirksamer Heparindosen ist nicht gesichert und sollte auf Patienten mit hohem Frührezidiv-oder Verschlechterungsrisiko beschränkt bleiben. Zur Prophylaxe des Hirnödems sind 20-30° Hochlagerung des Oberkörpers, optimale Atmung und Normothermie wesentlich. Hyperosmolare Lösungen sind nur bei eingetretener intrakranieller Druckerhöhung (nicht prophylaktisch) anzuwenden. Bei ausgedehnten, raumfordernden Infarkten ist eine Dekompressionsoperation möglich. Physikalische Therapie in der Frühphase verringert das Risiko von Sekundärschäden und verbessert die Chancen einer funktionellen und emotionellen Restitution.
[Analyses of ultrasonographs of adrenal gland cysts in comparison with pathological findings]. (2004)

Ultrasonography and CDFI can be an accurate diagnostic modality for adrenal gland cysts.
Genetically Modified Maize Resistant to Corn Earworm (Lepidoptera: Noctuidae) in Sinaloa, Mexico (2015)

Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae), the corn earworm, is a key pest causing damage to corn Zea mays L. (Poales: Poaceae). The development of hybrids expressing Cry1Ab, Vip3Aa20, and mCry3A protein of Bacillus thuringiensis Berliner (Bt) (Bacillales: Bacillaceae) is an option to control this insect. Corn hybrids Agrisure TM 3000 GT, Agrisure Viptera TM 3110, and Agrisure Viptera TM 3111 were tested for corn earworm suppression in the agricultural region of Sinaloa during the 2011, 2012, and 2013 autumn-winter growing seasons, and compared with their respective isolines. Gallery length on the ear and the number of damaged ears were evaluated. The genetically modified hybrids demonstrated the effectiveness of inserted proteins to confer resistance to the corn earworm by killing the pest or reducing its growth and damage to the ear. Based on the results, Agrisure TM 3000 GT, Agrisure Viptera TM 3110, and Agrisure Viptera TM 3111 are useful elements for an integrated pest management program on corn in Sinaloa, Mexico.
Social interaction in particle swarm optimization, the ranked FIPS, and adaptive multi-swarms (2008)

The interaction among particles is a vital aspect of Particle Swarm Optimization. As such, it has a strong influence on the swarm's success. In this study various approaches regarding the particles' communication behavior and their relationship are examined, as well as possibilities to combine the approaches. A new variant of the popular FIPS algorithm, the so-called Ranked FIPS, is introduced, which resolves specific shortcomings of the traditional FIPS. As all tested PSO variants feature distinct strengths and weaknesses, a new adaptive strategy is proposed which operates on dissimiliarly configured subswarms. The exchange between these subswarms is solely based on particle migration. The combination of the Ranked FIPS and other strategies within the so called Particle Swarm Optimizer with Migration achieves a very good, yet remarkably reliable performance over a wide range of recognized benchmark problems.
Yield enhancement effects of boosted dual word-line (BDWL) scheme for high density DRAMs (1996)

This paper describes the yield enhancement effects of a boosted dual word-line (BDWL) scheme for the first Al wiring in high density DRAMs, with a defect density model and a yield model used for comparison with that of the commonly used word-shunt (WS) scheme. Additionally, the yield of first Al wiring with a step height between memory cell array and peripheral circuit regions is also estimated. The yield estimation demonstrated that the yield enhancement effect of the wide first Al wiring for the BDWL scheme was comparable with or surpassed that of the redundancy for the WS scheme yield, when the first Al wiring pitch over the memory cell array or a BDWL scheme was over 4 times wider than that of the WS scheme. The yield estimation with step height indicated that the first Al wiring yield of the BDWL scheme with the step height exceeded that of the WS scheme with the step height of zero, even if using some global planarization technology.
Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei (2018)

Excess DUX4c could disturb cytoskeletal organization and nuclear distribution in FSHD myotubes. We suggest that DUX4c up-regulation could contribute to DUX4 toxicity in the muscle fibers by favoring the clustering of myonuclei and therefore facilitating DUX4 diffusion among them. Defining DUX4c functions in the healthy skeletal muscle should help to design new targeted FSHD therapy by DUX4 or DUX4c inhibition without suppressing DUX4c normal function.
Architecture-driven software mobility in support of QoS requirements (2008)

Over the past decade researchers have shown that software architecture provides an appropriate level of granularity for assessing a system's Quality of Service (QoS) properties (e.g., latency). Similarly, many previous works have adopted an architecture-centric approach to reason about the runtime adaptation, including component mobility, of software systems. However, the relationship between software architecture, QoS, and mobility is not clearly understood. In this paper, we present a framework that takes an explicit software architecture perspective for assessing the system's QoS properties, and improving it through architectural mobility. We describe the implementation of the framework, as well as some of the remaining challenges that frame our ongoing work.
A sanctuary for mobile agents (1997)

ly, this is a circuit of the (complete) graph connecting the airline servers, and the originator may chose this circuit at the time of agent dispatch. At any honest server, the agent code and its read-only state is checked when the agent arrives, so if the malicious server tries to tamper with the agent code or the read-only state the malicious server can not successfully pass the modified agent to an honest server. (Alternatively, the agent code and the read-only state may be considered to be reloaded from the originator by every server.) Furthermore, we assume that the variable agent state is transmitted among servers using authenticated and encrypted channels, so that only the server that is the intended migration target can receive the agent, as long as the agent is starting from an honest server. Thus, the malicious server can not intercept an agent as it migrates from an honest server to another server. At any server, an agent may query the server&apos;s identity. At first glance, thi...
Magnetic Deformation of Self-Assembled Sexithiophene Spherical Nanocapsules (2005)

We report the experimental observation of magnetic field deformation of spherical nanocapsules, self-assembled from sexithiophene molecules, into oblate spheroids, confirming a long-standing theoretical prediction. The magnetically deformed objects can be trapped in a compatible organogel to make them suitable for further investigations and applications. Our results show that strong magnetic forces can be effectively used, in a contact-free manner, as a tool to control the self-organization of a whole class of functional organic molecules.
Regulation of Primary Metabolic Pathways in Oyster Mushroom Mycelia Induced by Blue Light Stimulation: Accumulation of Shikimic Acid (2015)

Shikimic acid is a key intermediate in the aromatic amino acid pathway as well as an important starting material for the synthesis of Tamiflu, a potent and selective inhibitor of the neuraminidase enzyme of influenza viruses A and B. Here we report that in oyster mushroom (Pleurotus ostreatus) mycelia cultivated in the dark, stimulation with blue light-emitting diodes induces the accumulation of shikimic acid. An integrated analysis of primary metabolites, gene expression and protein expression suggests that the accumulation of shikimic acid caused by blue light stimulation is due to an increase in 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase (DAHPS, EC2.5.1.54), the rate-determining enzyme in the shikimic acid pathway, as well as phosphofructokinase (PFK, EC2.7.1.11) and glucose-6-phosphate dehydrogenase (G6PD, EC1.1.1.49), the rate-determining enzymes in the glycolysis and pentose phosphate pathways, respectively. This stimulation results in increased levels of phosphoenolpyruvic acid (PEP) and erythrose-4-phosphate (E4P), the starting materials of shikimic acid biosynthesis.
Evidence for genetic heterogeneity in Best's vitelliform macular dystrophy. (1995)

Best's vitelliform macular dystrophy is an early onset, autosomal dominant macular degeneration. Linkage analysis has previously mapped a disease locus in this disorder to the pericentromeric region of chromosome 11. We examined two families, one of German and one of Irish origin, both affected with this disorder. The Irish family (BTMD1) showed strong evidence for linkage to the previously reported locus on chromosome 11. Linkage of the disease locus to the same region of chromosome 11 has been significantly excluded in the German family (Fam E), thereby providing evidence of locus heterogeneity in this clinically unique condition.
Breast cancer stem cell targets. (2011)

The publication of the landmark paper by Al-Hajj et al, which demonstrated that breast cancer cells capable of tumor outgrowth when transplanted into the cleared mammary fatpad of immunocompromised mice could be prospectively identified using cell surface markers,[1] galvanized the cancer stem cell debate among breast cancer researchers and launched an exponential increase in papers exploring “breast cancer stem cells.”