gebhart/patrepeval huggingface dataset:
A Click Chemistry‐Based Proteomic Approach Reveals that 1,2,4‐Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile (2016)

In spite of the recent increase in endoperoxide antimalarials under development, it remains unclear if all these chemotypes share a common mechanism of action. This is important since it will influence cross-resistance risks between the different classes. Here we investigate this proposition using novel clickable 1,2,4-trioxolane activity based protein-profiling probes (ABPPs). ABPPs with potent antimalarial activity were able to alkylate protein target(s) within the asexual erythrocytic stage of Plasmodium falciparum (3D7). Importantly, comparison of the alkylation fingerprint with that generated from an artemisinin ABPP equivalent confirms a highly conserved alkylation profile, with both endoperoxide classes targeting proteins in the glycolytic, hemoglobin degradation, antioxidant defence, protein synthesis and protein stress pathways, essential biological processes for plasmodial survival. The alkylation signatures of the two chemotypes show significant overlap (ca. 90 %) both qualitatively and semi-quantitatively, suggesting a common mechanism of action that raises concerns about potential cross-resistance liabilities.
Tandem accelerators in Romania: Multi-tools for science, education and technology (2017)

An educated selection of the main beam parameters - particle type, velocity and intensity, can result in a cutting-edge scalpel to remove tumors, sanitize sewage, act as a nuclear forensics detective, date an artefact, clean up air, improve a microprocessor, transmute nuclear waste, detect a counterfeit or even look into the stars. Nowadays more than particle accelerators operate worldwide in medicine, industry and basic research. For example the proton therapy market is expected to attain 1 billion US$ per year in 2019 with almost 330 proton therapy rooms, while the annual market for the ion implantation industry already reached 1.5 G$ in revenue [1,2]. A brief history of the Tandem Accelerators Complex at IFIN-HH [3] emphasizing on their applications and the physics behind the scenes, is also presented [4-6].
Long Term Improvements in Patients with Chronic Fatigue Syndrome Treated with Ampligen (1995)

Fifteen patients who fit the CDC definition of chronic fatigue syndrome (CFS) and had evidence of severe reduction in performance levels by low Kamofsky performance scores (KPS) of 20-60 were treated with Ampligen. At baseline most patients showed evidence of cerebral dysfunction by neuropsychological testing, were antigen positive by cell culture assay for human herpesvirus-6 (HHV-6), and displayed reduced performance during exercise tolerance testing, as measured by oxygen consumption. These patients represented a subset of CFS patients with especially severe and sustained symptomatology. Following 1248 weeks of Ampligen therapy, sustained improvements were noted in KPS (p < 0.01). Cognitive function improved including IQ and memory. Oxygen uptake and treadmill duration during exercise tolerance testing was also improved after 24 weeks of treatment (p < 0.01). Reduction in HHV-6 expression as measured by the giant cell assay was significant (p < 0.001). Patients continued to show significant improvement late in therapy, taking 8 to 12 weeks as baseline. It was concluded that while receiving Ampligen, the severely afflicted patients studied here derived long-lasting clinical benefit from the Ampligen therapy.
Measurement of Insulation Resistance with Megohmmeter and its Application (2000)

The measurement of insulation resistance is necessary for electrical engineering.The breakdowns can be found out in advance and avoided in electrical system.Special attention must be paid by the persons for installation,measurement and operational maintenance of electrical equipment.The paper points out some factors affecting the measurement of insulation resistance with megohmmeter as well as cautions during measurement.
[Mercury emission characteristics from coal-fired power plants based on actual measurement]. (2011)

To sample and test mercury emission characteristics in different power plants, six representative coal-fired power plants were selected. And based on the data of mercury emission concentration from actual measurement, mercury removal rate and mercury average emission factor of every plant can be calculated, and mercury emission characteristics about every level capacity can be given, so as to provide support and foundation for the mercury control in China. The mercury emission concentration is about 4.72-14.54 microg/m3, mercury removal rate is about 20.89%-70.63%, and mercury average emission factor is about 14.09-56.08 microg/(kW x h). To compare the mercury emission characteristics with mercury emission characteristics from coal-fired power plants in USA, it is shown that the concentration of mercury emission from coal-fired power plants in China is far higher than those in USA, and the mercury removal rate is much lower than removal rate required by American national standard. To get conclusion that mercury average emission factor can come down with installed capacity and power generation load went up. And the function relation have been provided through comprehensive simulation between mercury average emission factor and installed capacity, generation load, mercury content in coal, the environmental protection equipment running level, and so on.
Time-dependent Photomodulation of a Single Atom Tungsten Tip Tunnelling Barrier (2010)

There has been much work on electron emission. It has lead to the concept of the photon and new electron sources for imaging\nsuch as electron microscopes and the rst formulation of holographic reconstructions [1-6]. Analytical derivations are important\nto gain physical insight into the problem of developing better electron sources. However, to date, such formulations have su ered\nby a number of approximations that have masked important physics. In this thesis, a new approach is provided that solves the\nSchrodinger wave equation for photoemission from a single atom tungsten tip barrier or more generally, for photoemission from\na Schottky triangular barrier potential, with or without image potential e ects. We describe the system, then introduce the\nmathematical derivation. We conclude with the applications of the theory.
对执法造成名誉损害的救济——源自李文和案、史蒂文·哈特费尔案以及布兰顿·梅菲尔德案的思考 (2012)

保罗诉戴维斯案作出裁决后,在相当长的一段时间内,由执法行为造成的名誉侵权损害都无法得到救济。而最近的李文和、史蒂文·哈特费尔以及布兰顿·梅菲尔德隐私诉讼案中原告依据联邦隐私法获得了经济赔偿,使得人们重新思考执法行为造成的名誉损害的救济途径。而联邦隐私法不能作为执法造成的名誉损害的救济措施。本文主张建立一方面威慑罪犯另一方面又能赔偿被错当做罪犯的受害者的新的立法救济模式。要建立这种新的立法救济模式,完善对执法中侵犯公民名誉的救济制度还有许多工作要做。
The Foundation of Our Religion (2006)

Research Article| January 01 2006 The Foundation of Our Religion Review of John W. Welch and Erick B. Carlson, eds. Opening the Heavens: Accounts of Divine Manifestations, 1820–1844. Salt Lake City: Brigham Young University Press and Deseret Book, 2005. xii + 500 pp., with index. $32.95. Kevin L. Barney Kevin L. Barney Kevin L. Barney earned his JD at the University of Illinois. He is a partner with Kutak Rock LLP in Chicago. Search for other works by this author on: This Site Google The FARMS Review (2006) 18 (2006) (2): 179–187. https://doi.org/10.5406/farmsreview.18.2.0179 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Kevin L. Barney; The Foundation of Our Religion. The FARMS Review 1 January 2006; 18 (2006) (2): 179–187. doi: https://doi.org/10.5406/farmsreview.18.2.0179 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressMormon Studies Review Search Advanced Search The text of this article is only available as a PDF. Copyright 2006 by the Board of Trustees of the University of Illinois2006 Article PDF first page preview Close Modal You do not currently have access to this content.
The Eosinophil As An Effector Cell of the Immune Response During Hepatic Allograft Rejection (1994)

Patients with severe rejection in the first month after liver transplantation often have blood eosinophilia and marked infiltration of portal tracts with eosinophils or evidence of eosinophil degranulation. The presence of major basic protein likely is direct evidence of tissue destruction and may indicate active rejection (major basic protein in eosinophils and extracellular major basic protein, presence of portal infiltrate) or the immediate postinflammatory rejection state (extracellular major basic protein and major basic protein inside littoral cells, absence of portal infiltrate and eosinophils, bile ducts damaged or vanished). These findings underline the importance of the eosinophil as an integral part of the rejection process. We conclude that the presence of eosinophils or their secretion products in the first month after liver transplantation is an indicator of ongoing or recent allograft rejection.
Assistive/Socially Assistive Robotic Platform for Therapy and Recovery: Patient Perspectives (2013)

Improving adherence to therapy is a critical component of advancing outcomes and reducing the cost of rehabilitation. A robotic platform was previously developed to explore how robotics could be applied to the social dimension of rehabilitation to improve adherence. This paper aims to report on feedback given by end users of the robotic platform as well as the practical applications that socially assistive robotics could have in the daily life activities of a patient. A group of 10 former and current patients interacted with the developed robotic platform during a simulated exercise session before taking an experience-based survey. A portion of these participants later provided verbal feedback as part of a focus group on the potential utility of such a platform. Identified applications included assistance with reaching exercise goals, managing to-do lists, and supporting participation in social and recreational activities. The study participants expressed that the personality characteristics of the robotic system should be adapted to individual preferences and that the assistance provided over time should align with the progress of their recovery. The results from this study are encouraging and will be useful for further development of socially assistive robotics.
Combinatorial Approaches for the Identification of Brain Drug Delivery Targets (2014)

The blood-brain barrier (BBB) represents a large obstacle for the treatment of central nervous system diseases. Targeting endogenous nutrient transporters that transcytose the BBB is one promising approach to selectively and noninvasively deliver a drug payload to the brain. The main limitations of the currently employed transcytosing receptors are their ubiquitous expression in the peripheral vasculature and the inherent low levels of transcytosis mediated by such systems. In this review, approaches designed to increase the repertoire of transcytosing receptors which can be targeted for the purpose of drug delivery are discussed. In particular, combinatorial protein libraries can be screened on BBB cells in vitro or in vivo to isolate targeting peptides or antibodies that can trigger transcytosis. Once these targeting reagents are discovered, the cognate BBB transcytosis system can be identified using techniques such as expression cloning or immunoprecipitation coupled with mass spectrometry. Continued technological advances in BBB genomics and proteomics, membrane protein manipulation, and in vitro BBB technology promise to further advance the capability to identify and optimize peptides and antibodies capable of mediating drug transport across the BBB.
Distributed implementation of real-time resource counters (1991)

The problem of managing telephone network resources for private virtual networks is discussed. Implementing a real-time resource counter on a distributed system is investigated. A correctness condition is developed for a real-time resource counter, and several approaches to implementing it are described. The various approaches are evaluated on a model that accounts for load-dependent message-processing delays, using both analytic and simulation techniques. The results of the performance studies also suggest heuristics for configuring a resource counter on a distributed system. A very simple approach, in which requests that cannot be satisfied locally are randomly forwarded to other processors, works well over a wide range of loads and system sizes. Unless a very large number of processors is required to handle the requests for resources or heavy overloads are expected, this may be the best algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
First application of core-shell Ag@Ni magnetic nanocatalyst for transfer hydrogenation reactions of aromatic nitro and carbonyl compounds (2012)

A magnetically separable core-shell Ag@Ni nanocatalyst was prepared by a simple one-pot synthetic route using oleylamine both as solvent and reducing agent and triphenylphosphine as surfactant. The synthesized nanoparticles were characterized by several techniques such as X-ray diffraction pattern (XRD), high resolution transmission electron microscopy (HR-TEM), selected area electron diffraction (SAED) pattern, and energy dispersive X-ray spectroscopy (EDS). The core-shell Ag@Ni nanocatalyst was found to have very excellent activity for the transfer hydrogenation reactions of aromatic nitro and carbonyl compounds under mild conditions using isopropyl alcohol as hydrogen donor. Excellent chemoselectivity and regioselectivity for the nitro group reduction was demonstrated.
Performances of the Obelix event builder and producer (1993)

The Obelix data-acquisition system is designed to collect data coming from four major subdetectors. It reduces and formats them into a structure suitable for the online monitoring and the data analysis. The event builder and producer is the kernel of the Obelix online system. The data from each subdetector flow in parallel into the global event builder memory. Then they are sent to the host computer where the producer injects them into the buffer manager for recording and monitoring. The event builder and producer tasks are integrated within the overall run control system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Novel Aluminum‐Ion Battery: Al/AlCl<sub>3</sub>‐[EMIm]Cl/Ni<sub>3</sub>S<sub>2</sub>@Graphene (2016)

Due to an ever‐increasing demand for electronic devices, rechargeable batteries are attractive for energy storage systems. A novel rechargeable aluminum‐ion battery based on Al 3+ intercalation and deintercalation is fabricated with Ni 3 S 2 /graphene microflakes composite as cathode material and high‐purity Al foil as anode. This kind of aluminum‐ion battery comprises of an electrolyte containing AlCl 3 in an ionic liquid of 1‐ethyl‐3‐methylimidazolium chloride ([EMIm]Cl). Galvanostatic charge/discharge measurements have been performed in a voltage range of 0.1–2.0 V versus Al/AlCl 4 − . An initial discharge specific capacity of 350 mA h g −1 at a current density of 100 mA g −1 is achieved, and the discharge capacity remains over 60 mA h g −1 and coulombic efficiency of 99% after 100 cycles. Typically, for the current density at 200 mA g −1 , the initial charge and discharge capacities are 300 and 235 mA h g −1 , respectively. More importantly, it should be emphasized that the battery has a high discharge voltage plateau (≈1.0 V vs Al/AlCl 4 − ). These meaningful results represent a significant step forward in the development of aluminum‐ion batteries.
Phage-Based Electrochemical Biosensors for Detection of Pathogenic Bacteria (2015)

A new type of impedimetric biosensor has been developed for rapid and selective detection of bacteria using T2 bacteriophage (virus) as the bio-recognition element on carbon nanotube (CNT) modified screen-printed electrode (SPE). Successful functionalization of the CNT surface was confirmed by ATR-FTIR. The immobilization of bacteriophage on SPE was achieved via simultaneous covalent bonding and electrostatic interaction. The phage-modified electrodes were used for the detection of the bacterial strain E. coli B (ATCC 11303). The attachment of bacteria to the phage-modified electrodes was confirmed by scanning electron microscopy. Electrochemical impedance spectroscopy was used to detect the variation of impedance of the electrodes resulting from the binding of E. coli B to T2 phage. The detection was highly selective towards the B strain of E. coli as no signal was observed for the K strain of E. coli . The present achievable detection limit of the biosensor is 50 CFU/mL.
Reflowable Sn-Pb bump formation on Al pad by a solder bumping method (2002)

A new solder bump material for reflow soldering on an Al pad was developed by using a rapidly solidified 60 Sn-29 Pb-5 Sb-1 Zn-5 Ag(mass%) alloy wire. The balls made from the wire by arc discharge in Ar+10%H/sub 2/ gas were bonded on an Al-1mass%Si film by thermosonic bonding at 398 K using a wire bonding machine. The bonding to the Al-Si film was made by the interdiffusion of Sn, Sb, Ag and Al through microfissures which occurred on the film surface. The as-bonded bump can be spheroidized by heating at 473 K with an inactivated rosin base flux. The shear strength of the reflowed bump is 79 MPa and decreases with increasing reflow temperature. According to the thermal fatigue life test of the solder bump applied to the flip-chip bonding, the striations formed by the fatigue fracture were observed to generate at very fine intervals of 0.08-0.12 /spl mu/m. These results are good enough to expect practical application of the direct solder bump formation technique on Al pad.
Changes in Lipid Peroxidation and Antioxidant Trace Elements in Serum of Women With Cervical Intraepithelial Neoplasia and Invasive Cancer (2003)

This study investigated serum lipid peroxidation, antioxidant capacity, and trace element levels in Korean women as related to uterine cervical neoplasia. Twenty-eight subjects had cervical intraepithelial neoplasia (CIN), 36 had invasive cervical cancer, as determined by a colposcopically directed biopsy, and controls included 44 subjects with normal colposcopic findings. Significantly lower selenium (Se) and zinc (Zn) levels and higher copper/Zn ratios were found in both CIN and cancer patients compared with the controls. Serum malondialdehyde levels decreased significantly in the order CIN>cancer>control, implying the involvement of reactive oxygen species at the precancerous stage, that is, prior to progression into invasive cervical cancer. Serum glutathione peroxidase activity was significantly lower in patients with CIN or cancer than controls, and total antioxidant ability decreased from controls to CIN to cancer (P < 0.0001). This study demonstrated the involvement of lipid peroxidation, decreased Se and Zn levels, and an impaired serum antioxidant system in the pathogenesis of cervical dysplasia. Further research is needed to examine the possibility of an effective chemopreventive treatment in cervical cancer based on enhancing the endogenous antioxidant system.
Face Recognition by Applying Wavelet Subband Representation and Kernel Associative Memory (2004)

In this paper, we propose an efficient face recognition scheme which has two features: 1) representation of face images by two-dimensional (2-D) wavelet subband coefficients and 2) recognition by a modular, personalised classification method based on kernel associative memory models. Compared to PCA projections and low resolution "thumb-nail" image representations, wavelet subband coefficients can efficiently capture substantial facial features while keeping computational complexity low. As there are usually very limited samples, we constructed an associative memory (AM) model for each person and proposed to improve the performance of AM models by kernel methods. Specifically, we first applied kernel transforms to each possible training pair of faces sample and then mapped the high-dimensional feature space back to input space. Our scheme using modular autoassociative memory for face recognition is inspired by the same motivation as using autoencoders for optical character recognition (OCR), for which the advantages has been proven. By associative memory, all the prototypical faces of one particular person are used to reconstruct themselves and the reconstruction error for a probe face image is used to decide if the probe face is from the corresponding person. We carried out extensive experiments on three standard face recognition datasets, the FERET data, the XM2VTS data, and the ORL data. Detailed comparisons with earlier published results are provided and our proposed scheme offers better recognition accuracy on all of the face datasets.
Synthesis and Proton Conductivity of Partially Sulfonated Poly([vinylidene difluoride-<i>c</i><i>o</i>-hexafluoropropylene]-<i>b</i>-styrene) Block Copolymers (2005)

A series of novel, amphiphilic block copolymers comprising of sulfonated poly([vinylidene difluoride-co-hexafluoropropylene]-b-styrene) [P(VDF-co-HFP)-b-SPS] were synthesized. The number-average molecular weights of the fluorous and polystyrene segments were 17 900 and 8100 g/mol, respectively. Sulfonation of the polystyrene segment to different extents provided a series of polymers which were cast into films to yield proton exchange membranes with varying ion exchange capacity (IEC). Proton conductivity of the membranes increased significantly when the IEC was increased from 0.5 to 1.2 mmol/g. For 0.9−1.2 mmol/g IEC membranes, the conductivity was similar to Nafion 117, significantly higher than random copolymers of polystyrene and sulfonated polystyrene, and twice that of nonfluorous block copolymer membranes based on sulfonated poly(styrene-b-[ethylene-co-butylene]-b-styrene) (S-SEBS) and sulfonated hydrogenated poly(butadiene-b-styrene) (S-HPBS) copolymers. TEM revealed a disruption in ordered morphology with increasing degree of sulfonation. Morphological structures of membranes having 0.6−1.2 mmol/g IEC comprised of interconnected networks of ion channels, each of 8−15 nm width.
Conformal prediction: A unified review of theory and new challenges (2022)

In this work we provide a review of basic ideas and novel developments about Conformal Prediction — an innovative distribution-free, non-parametric forecasting method, based on minimal assumptions — that is able to yield in a very straightforward way prediction sets that are valid in a statistical sense also in the finite sample case. The discussion provided in the paper covers the theoretical underpinnings of Conformal Prediction, and then proceeds to list the more advanced developments and adaptations of the original idea.
Efficient Enumeration of Minimal Unsafe States in Complex Resource Allocation Systems (2013)

An earlier work of ours has proposed a novel approach for the deployment of the maximally permissive deadlock avoidance policy for complex resource allocation systems (RAS), that is based on the identification and the efficient storage of a critical subset of states of the underlying RAS state space; the availability of this information enables an expedient one-step-lookahead scheme for the identification and blockage of transitions that will take the system behavior outside its safe region. This paper complements the aforementioned results by introducing a novel algorithm that provides those critical states while avoiding the complete enumeration of the RAS state space.