gebhart/patrepeval huggingface dataset:
Wideband Dual-Frequency Dual-Polarized Dipole-Like Antenna (2011)

A wideband dual-frequency dual-polarized printed antenna is proposed for LTE, WLAN, and UWB systems. The dual-band antenna provides wide impedance bandwidths of 74% with respect to the center frequency of 2.725 GHz, and 39% with respect to the center frequency of 7.15 GHz. An open slot in the ground plane between the feed arms provides an orthogonal path to realize an embedded circularly polarized band at 2.35 GHz with an axial-ratio bandwidth of 16%. Dual-band characteristics are achieved by an asymmetrical dipole-like element and the coupling configuration between the T-shaped feed line and the wide ground-plane slot.
Genome-Wide Fitness Test and Mechanism-of-Action Studies of Inhibitory Compounds in Candida albicans (2007)

Candida albicans is a prevalent fungal pathogen amongst the immunocompromised population, causing both superficial and life-threatening infections. Since C. albicans is diploid, classical transmission genetics can not be performed to study specific aspects of its biology and pathogenesis. Here, we exploit the diploid status of C. albicans by constructing a library of 2,868 heterozygous deletion mutants and screening this collection using 35 known or novel compounds to survey chemically induced haploinsufficiency in the pathogen. In this reverse genetic assay termed the fitness test, genes related to the mechanism of action of the probe compounds are clearly identified, supporting their functional roles and genetic interactions. In this report, chemical-genetic relationships are provided for multiple FDA-approved antifungal drugs (fluconazole, voriconazole, caspofungin, 5-fluorocytosine, and amphotericin B) as well as additional compounds targeting ergosterol, fatty acid and sphingolipid biosynthesis, microtubules, actin, secretion, rRNA processing, translation, glycosylation, and protein folding mechanisms. We also demonstrate how chemically induced haploinsufficiency profiles can be used to identify the mechanism of action of novel antifungal agents, thereby illustrating the potential utility of this approach to antifungal drug discovery.
Prenatal molecular diagnosis of gaucher disease (1995)

Prenatal diagnosis of Gaucher disease, the most prevalent glycolipid storage disease, is based on a reliable enzyme assay of cells from amniocentesis or chorionic villous samples. However, this method cannot differentiate among the various forms of the disease. This report details four cases of prenatal diagnosis of Gaucher disease, three of which predate the use of molecular diagnosis. DNA mutation analysis to determine the genotype was predictive of the phenotypic status of the fetus and conformed to the genotype of an affected proband where available.
Cationic Antimicrobial Peptides and Their Multifunctional Role in the Immune System (2000)

Many species of life contain cationic antimicrobial peptides as components of their immune systems. The antimicrobial activity of these peptides has been studied extensively, and many peptides have a broad spectrum of activity not only against gram-negative and gram-positive bacteria but also against antibiotic-resistant bacteria, fungi, viruses, and parasites. Such cationic antimicrobial peptides can also act in synergy with host molecules, such as other cationic peptides and proteins, lysozyme, and also conventional antibiotics, to kill microbes. It has been found that certain peptides are produced in large quantities at sites of infection/inflammation, and their expression can be induced by bacterial products such as endotoxic lipopolysaccharide (LPS) and proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha). These peptides often have a high affinity for bacterial products, such as LPS, allowing them to modulate the host response and reduce the inflammatory response in sepsis. More recently, they have been found to interact directly with host cells to modulate the inflammatory process and innate defenses.
Strong Bandwidth and Efficiency Improvement by Passive Pulse Shaping in Cavity-Enhanced OPCPA (2009)

An enhancement cavity can optimally reshape the small-signal gain across the interacting pulses of a chirped-pulse parametric amplifier, increasing the gain bandwidth dramatically while simultaneously boosting the conversion efficiency.
Hybrid Organic—Inorganic Solids for Heterogeneous Asymmetric Catalysis (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of an implantable networked neuroprosthesis (2005)

Neuroprosthetic devices are powerful tools providing functional enhancement for individuals with central nervous system disorders, such as spinal cord injury and stroke. Life sustaining and enhancing independent functions such as breathing, standing, walking, grasping, reaching, micturition, and defecation have all been clinically demonstrated using neuroprostheses. Existing implanted neuroprosthetic systems utilize considerable external powering and signal processing, and each system must be customized to the specific application for which it is intended, severely limiting progress in the field and delaying the introduction of new technology to the end user. The networked neuroprosthetic system (NNPS) is based on a network of small implanted modules, distributed throughout the body, and linked to a centralized power source. The modules are connected through a network cable that distributes power to each module from a central rechargeable lithium-ion battery. Each module contains processing capabilities, communicates with other modules via the network cable, and is reprogrammable over the network using a central wireless transcutaneous link. The NNPS is extremely flexible and can be scaled to meet the technical needs of a broad range of neuroprosthetic applications through the selection of the appropriate modules providing the means for broader clinical application of neuroprostheses
A covariance-based algorithm: A novel technique for rhythm discrimination in ICDs (2008)

Inappropriate shocks due to misclassification of supraventricular and ventricular arrhythmias remain a major problem in the care of patients with Implantable Cardioverter defibrillators (ICDs). In this study we have investigated the ability of a new covariance-based algorithm, to distinguish Ventricular Tachycardia from other rhythms such as Supraventricular Tachycardia. The proposed algorithm has a low computational demand and with a small adjustment is applicable on both single-chamber and dual-chamber ICDs. The results are promising and suggest that the new covariance-based algorithm may be an effective method for ICD rhythm classification and may decrease inappropriate shocks.
Information Theory Based Radar Signature Analysis (2007)

The ability to make radar signature databases portable for use within similar sensor systems is critical to the affordability of airborne signature exploitation systems. The capability to hybridize measured and synthetic signature database components will maximize the investment required to build complex radar signature databases. Radar target scattering response signatures and sensor related effects can be modeled and analyzed as a random process to enable sensor optimization. Information theory based methods are proposed as a means to identify those components within the signal subspace that are highly linked to target separability. Mutual information is developed as a measure of similarity to compare measured field data to modeled synthetic data. The approach is demonstrated using synthetic signature sets comprised of both "similar targets" and "dissimilar targets".
Topology Discovery for Linear Wireless Networks With Application to Train Backbone Inauguration (2016)

A train backbone network consists of a sequence of nodes arranged in a linear topology. A key step that enables communication in such a network is that of topology discovery (TD), or train inauguration, whereby nodes learn in a distributed fashion the physical topology of the backbone network. While the current standard for train inauguration assumes wired links between adjacent backbone nodes, this work investigates the more challenging scenario in which the nodes communicate wirelessly. The key motivations for this desired switch from wired TD to wireless one are the flexibility and capability for expansion and upgrading of a wireless backbone. The implementation of TD over wireless channels is made difficult by the broadcast nature of the wireless medium, as well as by fading and interference. A novel TD protocol is proposed, which overcomes these issues and requires relatively minor changes to the wired standard. The protocol is shown via analysis and numerical results to be robust to the impairments caused by the wireless channel, including interference from other trains.
A single controller for inductive power transfer systems (2009)

Contactless or inductive power transfer (IPT) is preferred for numerous applications, ranging from microwatt bio-engineering devices to high power battery charging systems. Typical IPT systems invariably require a separate controller on both powering and receiving sides of the system to facilitate contactless power transfer in an efficient and controllable way. This paper presents a new IPT control technique, which requires only a single controller located on the powering side to effectively control the amount of `contactless' power delivery to the receiving side. Both theoretical analysis and simulated results are presented to validate the viability of the proposed technique, which is unique in contrast to the existing IPT technology, and low in cost with only one controller.
Cross-Reaction between Gliadin and Different Food and Tissue Antigens (2013)

A subgroup of coeliac disease patients continues to experience symptoms even on a gluten-free diet (GFD). We attempted to determine whether these symptoms could be due to either cross-contamination with gluten-containing foods or cross-reactivity between α-gliadin and non-gluten foods consumed on a GFD. We measured the reactivity of affinity-purified polyclonal and monoclonal α-gliadin 33-mer peptide antibodies against gliadin and additional food antigens commonly consumed by patients on a GFD using ELISA and dot-blot. We also examined the immune reactivity of these antibodies with various tissue antigens. We observed significant immune reactivity when these antibodies were applied to cow’s milk, milk chocolate, milk butyrophilin, whey protein, casein, yeast, oats, corn, millet, instant coffee and rice. To investigate whether there was cross-reactivity between α-gliadin antibody and different tissue antigens, we measured the degree to which this antibody bound to these antigens. The most significant binding occurred with asialoganglioside, hepatocyte, glutamic acid decarboxylase 65, adrenal 21-hydroxylase, and various neural antigens. The specificity of anti-α-gliadin binding to different food and tissue antigens was demonstrated by absorption and inhibition studies. We also observed significant cross-reactivity between α-gliadin 33-mer and various food antigens, but some of these reactions were associated with the contamination of non-gluten foods with traces of gluten. The consumption of cross-reactive foods as well as gluten-contaminated foods may be responsible for the continuing symptoms presented by a subgroup of patients with coeliac disease. The lack of response of some CD patients may also be due to antibody cross-reactivity with non-gliadin foods. These should then be treated as gluten-like peptides and should also be excluded from the diet when the GFD seems to fail.
Randomized modulation of power converters via Markov chains (1997)

Randomized modulation of switching in power converters holds promise for reducing filtering requirements and reducing acoustic noise in motor drive applications. This paper is devoted to issues in analysis and synthesis of randomized modulation schemes based on finite Markov chains. The main advantage of this novel type of randomized modulation is the availability of an explicit control of time-domain performance, in addition to the possibility of shaping the power spectra of signals of interest. We focus on the power spectra of the switching functions that govern converter operation, and on the power spectra of certain associated waveforms, numerical (Monte Carlo) and experimental verifications for our power spectral formulas are presented. We also formulate representative narrow- and wide-band synthesis problems in randomized modulation, and solve them numerically. Our results suggest that randomized modulation is very effective in satisfying narrow-band constraints, but has limited effectiveness in meeting wide-band signal power constraints.
Extending Service Life and Detecting Degradation of Poly(p-phenylene-2,6-benzobisoxazole) (PBO) Fiber (2015)

Poly(p-phenylene-2,6-benzobisoxazole) (PBO) fiber has a high strength, a high modulus, and is light weight, which makes it a leading candidate for soft body armor and fiber reinforced plastic composites. The use of PBO fiber in protective applications is limited by its mechanical degradation during service. Battelle has developed a supercritical (sc)CO2 chemical diffusion post processing method to treat PBO fiber that decreases the rate of mechanical properties degradation and increases its useable service life. The tensile data show that this treatment yields a 14 % increase for tenacity over untreated fibers after 120 days of accelerated aging (70 oC, 90 %RH) when using 3- glycidoxypropyldimethoxymethylsilane (GPDMS) epoxy silane as the chemical infused into PBO fibers. The epoxy silane chosen demonstrated an incremental increase in fiber life; with optimization, greater gains could be realized. Additionally, fluorescent spectroscopy was performed on methanol rinses of aged PBO fibers as an analytical method for determining extent of fiber degradation. Initial testing has indicated that the intensity of fluorescence peak emission have a correlation to the degradation level of the PBO fiber. There is potential for an analytical technique to be developed to test fibers from deployed soft armor to determine if the material still possesses ballistic protection, or if it should be removed from service.
Antagonists of LHRH with Histidine in the Priority Position 8 (1993)

Sixteen new designs of antagonists of the luteinizing hormone releasing hormone (LHRH) with histidine in position 8 were synthesized, because this position is critical both for antiovulatory activity and the side effect of histamine release. The most potent antagonist was NAcDQal-DpClPhe–D 3 Pal– Ser–cPzACAla–DPicLys– Leu– His – Pro –DAlaNH 2 , which showed 33% AOA at 0.25 μg. The histamine release was remarkably negligible by an ED 50 of 308 μg/ml which is superior to 186 μg/ml for LHRH and comparable to 300 for Antide. The relative basicities of His, Arg, and ILys in position 8 of antagonists appear to influence both the level of potency of AOA and a negligible to a significant release of histamine. The least basic His 8 -analogs can have the lowest AOA and the highest ED 50 . The very basic Arg 8 -analogs can have the highest AOA and the lowest ED 50 . The moderately basic ILys 8 -analogs can be a compromise for acceptable levels of potency and safety.
Water-free dyeing of textile accessories using supercritical carbon dioxide (1997)

Results are given about a new dyeing process for dyeing synthetic fibre material with disperse dyes. The use of supercritical carbon dioxide as dyeing medium completely avoids water pollution and the need of drying. Laboratory results show excellent levelness and fastnesses on the dyeing of poly(ethylene terephthalate) and polyamides. Especially, the good results are achievable for small lots like textile accessories. The state of technical development is briefly described.
Corrections to Design, Synthesis, and Biological Evaluation of 6α- and 6β-<i>N</i>-Heterocyclic Substituted Naltrexamine Derivatives as μ Opioid Receptor Selective Antagonists (2009)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrections to Design, Synthesis, and Biological Evaluation of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as μ Opioid Receptor Selective AntagonistsGuo Li, Lindsey C. Aschenbach, Jianyang Chen, Michael P. Cassidy, David L. Stevens, Bichoy H. Gabra, Dana E. Selley, William L. Dewey, Richard B. Westkaemper, and Yan Zhang*Cite this: J. Med. Chem. 2009, 52, 24, 8057Publication Date (Web):November 10, 2009Publication History Published online10 November 2009Published inissue 24 December 2009https://pubs.acs.org/doi/10.1021/jm9016224https://doi.org/10.1021/jm9016224correctionACS PublicationsCopyright © 2009 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views893Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (563 KB) Get e-AlertscloseSUBJECTS:Antagonists,Ligands,Molecular design,Reaction products,Receptors Get e-Alerts
Damage monitoring in fiber-reinforced composites under fatigue loading using carbon nanotube networks (2010)

The formation of carbon nanotube networks around the structural reinforcement in fiber composites has enabled in situ monitoring of matrix damage accumulation. Real-time monitoring of damage development under fatigue loading was studied. The electrical response of the fatigue specimens change synchronously with the applied fatigue loading and enable a quantitative measure of the damage state. The fatigue response of the nanotube network was examined and the damage accumulation validated using microscopic technique. Various damage stages in composite cross-ply laminates under fatigue loading can be clearly detected by adopting the quantitative parameter, damaged resistance change. The sensitivity of the technique to the onset and accumulation of damage may enable future life prediction methodologies.
Smart freeform optics solution for an extremely thin direct-lit application (2016)

Light-emitting diodes (LEDs) based lighting solutions offer many advantages like the huge potential for energy saving, long lifetime, high reliability and the compact size compared to incandescent light bulbs. Especially the last-mentioned aspect favors new concepts for the design and integration of light points and luminaires. In case of a direct-lit system for general lighting applications the LEDs are separated by a certain distance, arranged in a regular array and illuminate an out-coupling surface which is placed in a certain height above the LED array. One approach to fulfill the demand of a uniform luminance of the out-coupling surface is to replace the surface by a diffuser sheet. In order to allow for a flat luminaire design the distance of the out-coupling surface has to be modified synchronously with a variation of the distance between the LEDs. This means, in order to maintain the uniformity of the luminance the distance to height ratio (DHR) of the optical arrangement has to be kept constant. A (from the viewpoint of costs desirable) reduction of the number of the LEDs and as a consequence thereof an increase of the DHR value can be achieved by using additional optical elements like, e.g., freeform optics. However, this can cause additional design problems due to the size of such optical elements. In this contribution we discuss a smart design of an extremely flat direct-lit luminaire for general lighting applications. The main advantage of this concept is the increased DHR ratio compared to diffuser sheet only-approaches and a smaller thickness of the whole set-up compared to common freeform approaches. For this demand we have designed very thin freeform optical elements with a maximal height of 75 μm that allow to maintain a uniform illumination in direct-lit applications using an LED-array with a comparably large distance between the individual LEDs. The presented design concept in addition emphasizes the use of cost-effective manufacturing methods like grey scale laser lithography for mastering and roll-to-roll processing for large area manufacturing of these optical elements.
Amplified responses in materials using linear polymers that depolymerize from end‐to‐end when exposed to specific stimuli (2014)

ABSTRACT This review describes new types of smart materials that have the dual capabilities of responding to selective signals and providing an amplified response. Amplification arises from a signal‐induced depolymerization reaction, where a single signaling event causes an entire polymer to convert to small molecules. When incorporated into a material, depolymerization of these polymers causes a change in shape, internal structure, or surfaces properties of the material. Moreover, the small molecules arising from depolymerization can play a role in the amplified response, particularly when they provide a secondary function (e.g., production of color or fluorescence). A brief overview of the current examples of linear depolymerizable polymers is provided, as are representative proof‐of‐concept applications of these polymers in the context of diagnostics and materials that remodel themselves and/or their surroundings. Together, these examples highlight the potential of this new class of polymers to provide unique and dramatic function to stimuli‐responsive materials. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40992.