gebhart/patrepeval huggingface dataset:
Lumped-Element Realization of Absorptive Bandstop Filter With Anomalously High Spectral Isolation (2012)

In this paper, we show a new absorptive banstop filter topology that is capable of creating large attenuation using low- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> small-size resonators. In addition, the implementation of a lumped-element absorptive bandstop filter is shown for the first time. Compared with the conventional absorptive filter structure, the new absorptive filter structure is smaller in size because there is no quarter-wavelength transmission line between two resonators and the resonators are lumped elements. For verification of the new topology, a lumped-element low-temperature co-fired ceramic (LTCC) bandstop filter with low-Q resonators has been designed and measured. Theory, simulation, and measurement showed good agreement between them, and the measurement showed 60-dB attenuation level at the center frequency. This attenuation level of the absorptive bandstop filter is 50 dB larger than the one obtained from the reflective bandstop filter with the same Q-factor and bandwidth. The small size and absorptive nature of the filter allow us to cascade the filters to create many different filter responses. It is shown that the lumped-element implementation makes the filter very amenable to realization of higher order responses in small form factors.
Clinical characterization of patients with metastatic colorectal cancer depending on the KRAS status (2011)

This retrospective study investigated the clinical characteristics of patients with metastatic colorectal cancer (mCRC) depending on the KRAS status, thereby differentiating KRAS exon 2 mutations in codon 12 versus codon 13. In total, 273 patients with mCRC receiving first-line therapy were analyzed. One hundred patients were treated within the FIRE-3 trial (FOLFIRI plus cetuximab or bevacizumab), 147 patients within the AIO KRK-0104 trial (cetuximab plus CAPIRI or CAPOX), and further 26 patients received therapy outside the study. Thirty-eight tumors with KRAS mutation in codon 13, 140 tumors with mutation in codon 12, and 95 tumors with KRAS wild type as a comparison were included in this analysis. Bivariate analyses demonstrated significant differences between KRAS wild-type, codon 12-mutated, and codon 13-mutated tumors with regard to synchronous lymph node metastasis (P=0.018), organ metastasis (76.8% vs. 65.9% vs. 89.5%, P=0.009), liver metastasis (89.5% vs. 78.2% vs. 92.1%, P=0.025), lung metastasis (29.5% vs. 42.9% vs. 50%, P=0.041), liver-only metastasis (48.4% vs. 28.8% vs. 28.9%, P=0.006), and metastases in two or more organs (49.5, 61.4, 71.1, P=0.047). Regression models indicated a significant impact of KRAS mutations in codon 12 versus codon 13 for synchronous organ and nodal metastasis (P=0.01, 0.03). This pooled analysis indicates that mCRC is a heterogeneous disease, which seems to be defined by KRAS mutations of the tumor. Compared with KRAS codon 12 mutations, codon 13-mutated mCRC presents as a more aggressive disease frequently associated with local and distant metastases at first diagnosis.
A system-level overview and comparison of three High-Speed Serial Links: USB 3.0, PCI Express 2.0 and LLI 1.0 (2013)

High Speed Serial Links (HSSL) are found in almost all today's System-on-Chip (SoC) connecting different components: the main chip and its I/Os, chip to chip (the main chip to a companion chip, memory sharing between two chips), etc... A variety of standards exist, each of which is used for a specific application, and many parameters affect their performance. In this paper we make a comparison of three high-speed protocols, the USB 3.0, PCI Express 2.0 (PCIe) and LLI 1.0. We analyze their different parameters, mainly the data exchange protocol, errors management, the Bit Error Rate (BER), data efficiency and the quality of service (QoS) for each of the protocols. We also show the relation between these parameters and how improving one parameter could result in a degradation of another, and based on this analysis, we finish by concluding the reason why USB is used for I/Os, PCIe is used for data hungry devices and LLI for memory sharing.
The occurrence of leg ulcers in Auckland: results of a population-based study. (2002)

These data indicate that the risk of developing leg ulcers increases dramatically with age, with individuals aged 60 years and over particularly at risk. Given New Zealand's rapidly ageing population, the number of older people with leg ulcers each year is expected to double in the next 25 years.
Nanoelectromechanical resonator for logic operations (2017)

We report an electro-thermally tunable in-plane doubly-clamped nanoelectromechanical resonator capable of dynamically performing NOR, NOT, XNOR, XOR, and AND logic operations. Toward this, a silicon based resonator is fabricated using standard e-beam lithography and surface nanomachining of a highly conductive device layer of a silicon-on-insulator (SOI) wafer. The performance of this logic device is examined at elevated temperatures, ranging from 25 °C to 85 °C, demonstrating its resilience for most of the logic operations; thereby paving the way towards nano-elements-based mechanical computing.
RainFlow: Optical Flow Under Rain Streaks and Rain Veiling Effect (2019)

Optical flow in heavy rainy scenes is challenging due to the presence of both rain steaks and rain veiling effect, which break the existing optical flow constraints. Concerning this, we propose a deep-learning based optical flow method designed to handle heavy rain. We introduce a feature multiplier in our network that transforms the features of an image affected by the rain veiling effect into features that are less affected by it, which we call veiling-invariant features. We establish a new mapping operation in the feature space to produce streak-invariant features. The operation is based on a feature pyramid structure of the input images, and the basic idea is to preserve the chromatic features of the background scenes while canceling the rain-streak patterns. Both the veiling-invariant and streak-invariant features are computed and optimized automatically based on the the accuracy of our optical flow estimation. Our network is end-to-end, and handles both rain streaks and the veiling effect in an integrated framework. Extensive experiments show the effectiveness of our method, which outperforms the state of the art method and other baseline methods. We also show that our network can robustly maintain good performance on clean (no rain) images even though it is trained under rain image data.
Effect of phase compensation and damping on the open loop transfer function of a vented hearing aid worn <i>in situ</i> (1984)

An in-the-ear hearing aid having 120-dB peak SPL, 50-dB peak gain, and a 3-mm-diam vent mounted on Kemar was treated as a feedback control system. The feedback loop was broken between microphone and amplifier to obtain the magnitude and phase of the open loop transfer function and hence the proximity of the fitting to onset of acoustical feedback oscillation. With the loop closed, as the gain control was adjusted, the hearing aid generally oscillated if the open loop magnitude exceeded 0 dB. The frequency of acoustic feedback oscillation correlated fairly well to the frequency at which the open loop magnitude crossed 0 dB with gain decreasing. The same measurements were repeated with a phase compensator added between the hearing aid microphone and amplifier and with an acoustic resistance damper added in the tubing of the hearing aid receiver. Both the phase compensator and damper improved phase margin and hence rendered the hearing aid fitting less likely to oscillate.
Nitrile oxides in medicinal chemistry. 4. Chemoenzymic synthesis of chiral heterocyclic derivatives (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrile oxides in medicinal chemistry. 4. Chemoenzymic synthesis of chiral heterocyclic derivativesMarco De Amici, Paolo Magri, Carlo De Micheli, Francesca Cateni, Roberto Bovara, Giacomo Carrea, Sergio Riva, and Gianluigi CasaloneCite this: J. Org. Chem. 1992, 57, 10, 2825–2829Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/jo00036a013https://doi.org/10.1021/jo00036a013research-articleACS PublicationsRequest reuse permissionsArticle Views295Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A survey on inpainting techniques (2016)

Image inpainting is one of the image restoration technique used for reconstruction of lost or damaged region in an image. Images may contain distorted and undesired regions which are to be removed. The main objective of the inpainting algorithm is to replace these regions and fill up the holes in a natural way. The methods used for inpainting includes diffusion based, exemplar-based, hierarchical super-resolution-based and spatial patch blending methods. This paper aims at comparing the various techniques used for inpainting. These methods aim at hole filling and removing the artefacts such as texture garbage, blur effects and unconnected edges.
Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent (2002)

Because both HIV-1 virions and HIV-infected cells are present in the semen and cervical mucus of infected individuals, HIV-1 prevention strategies must consider both cell-free and cell-associated virus. Antibodies that target HIV-1 virions have been shown to prevent vaginal transmission of cell-free virus in macaques, but since cell-associated transmission has not been reliably demonstrated in this model system, no strategies to prevent such transmission have been tested. We have employed a mouse model in which SCID mice carry human peripheral blood leukocytes (HuPBLs). In these mice, vaginal transmission of cell-associated, but not cell-free, HIV-1 transmission occurs, mediated by transepithelial migration of HIV-infected cells. Topical application of beta-cyclodextrin (beta-CD), a cholesterol-sequestering agent that interferes with cell migration and budding of virus from lipid rafts, blocks transmission of cell-associated HIV-1. The HuPBL-SCID model of vaginal HIV-1 transmission should prove useful for investigating cell-associated HIV-1 transmucosal HIV-1 transmission, as well as for screening reagents for their potential efficacy in preventing sexual HIV-1 transmission.
Mostly-optimistic concurrency control for highly contended dynamic workloads on a thousand cores (2016)

Future servers will be equipped with thousands of CPU cores and deep memory hierarchies. Traditional concurrency control (CC) schemes---both optimistic and pessimistic---slow down orders of magnitude in such environments for highly contended workloads. Optimistic CC (OCC) scales the best for workloads with few conflicts, but suffers from clobbered reads for high conflict workloads. Although pessimistic locking can protect reads, it floods cache-coherence backbones in deep memory hierarchies and can also cause numerous deadlock aborts. This paper proposes a new CC scheme, mostly-optimistic concurrency control (MOCC), to address these problems. MOCC achieves orders of magnitude higher performance for dynamic workloads on modern servers. The key objective of MOCC is to avoid clobbered reads for high conflict workloads, without any centralized mechanisms or heavyweight interthread communication. To satisfy such needs, we devise a native, cancellable reader-writer spinlock and a serializable protocol that can acquire, release and re-acquire locks in any order without expensive interthread communication. For low conflict workloads, MOCC maintains OCC's high performance without taking read locks. Our experiments with high conflict YCSB workloads on a 288-core server reveal that MOCC performs 8× and 23× faster than OCC and pessimistic locking, respectively. It achieves 17 million TPS for TPC-C and more than 110 million TPS for YCSB without conflicts, 170× faster than pessimistic methods.
A framework for (re)deploying components in distributed real-time and embedded systems (2006)

This paper describes the Resource Allocation and Control Engine (RACE) that integrates multiple resource management algorithms for (re) deploying and managing performance of application components in distributed real-time and embedded (DRE) systems. RACE enables DRE systems to (re) configure allocation and control algorithms depending on application characteristics and environmental conditions. It also enables developers to focus on algorithm logic, while reusing many mechanisms used to (re)configure and (re)deploy the algorithms on distributed computing nodes.
LaAlO3/Si capacitors: Comparison of different molecular beam deposition conditions and their impact on electrical properties (2013)

A study of the structural and electrical properties of amorphous LaAlO3 (LAO)/Si thin films fabricated by molecular beam deposition (MBD) is presented. Two substrate preparation procedures have been explored namely a high temperature substrate preparation technique—leading to a step and terraces surface morphology—and a chemical HF-based surface cleaning. The LAO deposition conditions were improved by introducing atomic plasma-prepared oxygen instead of classical molecular O2 in the chamber. An Au/Ni stack was used as the top electrode for its electrical characteristics. The physico-chemical properties (surface topography, thickness homogeneity, LAO/Si interface quality) and electrical performance (capacitance and current versus voltage and TunA current topography) of the samples were systematically evaluated. Deposition conditions (substrate temperature of 550 °C, oxygen partial pressure settled at 10−6 Torr, and 550 W of power applied to the O2 plasma) and post-depositions treatments were investigated to optimize the dielectric constant (κ) and leakage currents density (JGate at |VGate| = |VFB − 1|). In the best reproducible conditions, we obtained a LAO/Si layer with a dielectric constant of 16, an equivalent oxide thickness of 8.7 Å, and JGate ≈ 10−2A/cm2. This confirms the importance of LaAlO3 as an alternative high-κ for ITRS sub-22 nm technology node.
Concept of an upright wearable positron emission tomography imager in humans (2016)

To our knowledge, this is the first demonstration of imaging a human subject with a novel wearable PET imager that moves with robust head movements. We discuss potential research and clinical applications that will drive the design of a fully functional device. Designs will need to consider trade-offs between a low weight device with high mobility and a heavier device with greater sensitivity and larger field of view.
Polymeric Tissue Adhesives (2021)

Polymeric tissue adhesives provide versatile materials for wound management and are widely used in a variety of medical settings ranging from minor to life-threatening tissue injuries. Compared to the traditional methods of wound closure (i.e., suturing and stapling), they are relatively easy to use, enable rapid application, and introduce minimal tissue damage. Furthermore, they can act as hemostats to control bleeding and provide a tissue-healing environment at the wound site. Despite their numerous current applications, tissue adhesives still face several limitations and unresolved challenges (e.g., weak adhesion strength and poor mechanical properties) that limit their use, leaving ample room for future improvements. Successful development of next-generation adhesives will likely require a holistic understanding of the chemical and physical properties of the tissue-adhesive interface, fundamental mechanisms of tissue adhesion, and requirements for specific clinical applications. In this review, we discuss a set of rational guidelines for design of adhesives, recent progress in the field along with examples of commercially available adhesives and those under development, tissue-specific considerations, and finally potential functions for future adhesives. Advances in tissue adhesives will open new avenues for wound care and potentially provide potent therapeutics for various medical applications.
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity (2002)

IL-1F7 was discovered in expressed sequence tag databases as a member of the increasing family of proteins sharing sequence homology to IL-1alpha/beta, IL-1Ra, and IL-18. In the present study using immunohistochemical staining, IL-1F7 was localized in human peripheral monocytic cells, suggesting its role in immune regulation. Recombinant human IL-1F7b was shown to bind to the IL-18Ralpha but without IL-18 agonistic or antagonistic function. Using chemical cross-linking, we observed that, unlike IL-18, IL-1F7b fails to recruit the IL-18Rbeta chain to form a functionally active, ternary complex with the IL-18Ralpha chain. IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity. In testing whether IL-1F7b interacts with IL-18BP, we unexpectedly observed that IL-1F7b enhanced the ability of IL-18BP to inhibit IL-18-induced IFNgamma by 25-30% in a human natural killer cell line. This effect was observed primarily at limiting concentrations of IL-18BP (3.12-12.5 ng/ml) and at a 50- to 100-fold molar excess of IL-1F7b. Similar results were obtained by using isolated human peripheral blood mononuclear cells. To study the molecular basis of this effect we performed binding studies of IL-1F7b and IL-18BP. After cross-linking, a high molecular weight complex consisting of IL-1F7b and IL-18BP was observed on SDS/PAGE. We propose that after binding to IL-18BP, IL-1F7b forms a complex with IL-18Rbeta, depriving the beta-chain of forming a functional receptor complex with IL-18Ralpha and thus inhibiting IL-18 activity.
Proatrial natriuretic polypeptide (31-67) in healthy individuals: day-to-day variation and influence of sex and age (1995)

N-terminal parts of proatrial natriuretic polypeptide have been proposed to be sensitive and specific markers of congestive heart failure (CHF). A prerequisite for use of a clinical marker is knowledge of day-to-day variation and dependence on age and sex. Immunoreactive N-terminal proatrial natriuretic polypeptide (31-67) (ir-N-ANP(31-67)) was measured in a clinically relevant population of healthy individuals. A total of 21 females (mean age 52 years, range 42-76) and 26 males (mean age 54 years, range 42-73), without cardiovascular disease, were included in the study. No correlation was found between ir-N-ANP(31-67) and sex. A statistically significant positive linear correlation (ir-N-ANP pmol 1(-1) = 182+ (8.2 x age in years) (p = 0.004) was found between age and ir-N-ANP(31-67). For the youngest subjects (42 years) the expected mean ir-N-ANP(31-67) was 530 pmol 1(-1), and for the oldest subjects (76 years) it was 800 pmol 1(-1). For all the subjects, the median ir-N-ANP(31-67) was found to be 626 pmol 1(-1) (range 300-1151). The day-to-day variation was studied and no significant difference was found in the plasma concentration of two samples taken 2-5 days apart. Of the individual day-to-day variation, 95% would be expected to be in the interval from -244 to 188 pmol 1(-1) (mean +/- 2 x SD). We conclude that ir-N-ANP(31-67) rises with age. The age-dependent rise in ir-N-ANP(31-67) is modest, but should be taken into consideration in order to use ir-N-ANP(31-67) as a diagnostic marker of CHF. The day-to-day variation is found to be rather high and cannot be neglected if N-ANP(31-67) is to be used as a marker of asymptomatic heart failure.
More applications of uncooled microbolometer sensors (1998)

Lockheed Martin IR Imaging Systems is developing low cost, high performance, uncooled infrared imaging products for both military and commercial applications. These products are based on microbolometer technology, a silicon micromachined sensor that combines wafer level silicon processing with a device structure capable of yielding excellent imaging performance. Here, in the first of a series of papers, we report on several applications that are utilizing the Lockheed Martin microbolometer sensor. The performance of our basic uncooled sensor has been measured (and reported in multiple papers) to determine sensor capabilities for insertion into both military and commercial products. Non-linearity of the sensor over a scene temperature range of 95 degrees Celsius is less than 0.5%. Our sensors typically have temporal NETDs of less than 70 mK as well as spatial NETDs of less than 50 mK. MRTD performance is less than 0.4 degrees Celsius at spatial frequencies more than 20% beyond Nyquist. Spatial noise variation over time has been measured and found to meet both commercial and military requirements with excellent spatial noise over wide scene and ambient temperature ranges. Some of the multiple applications in which our uncooled sensors have been used have just recently been described in one report demonstrating the varied and unique uses of this product. Our sensor is now used by dozens of partners and customers for applications ranging from hand-held radiometric cameras to driving aids; from driver's aids to miniature cameras from rifle sights to radiometers. These applications will be discussed along with their unique system level performance parameters. Video will be used to demonstrate the various applications discussed.
A fast detection algorithm suitable for mitigation of numerous power quality disturbances (2005)

In this paper, a fast detection method for voltage disturbances is explored. The proposed method provides reliable and fast detection for either single-phase or polyphase voltage disturbances such as voltage sags, voltage swells, flicker, frequency change in the utility voltage, and harmonic distortion. The algorithm is based on the theory that allows a set of three-phase voltages be represented as dc voltages in a d-q synchronous rotating frame. In this case, the utility input voltages are sensed and then converted to dc quantities in the d-q reference frame. Thus, any disturbance at the utility input voltages will be promptly reflected as disturbances in the d-q values. Further processing of the signals minimizes the point-on-wave effect and yields a trip signal indicating if the disturbance is a voltage sag or a voltage swell. Analysis, simulation, and experimental results are presented for a three-phase system. The proposed algorithm is implemented on a digital signal processor (DSP)-based system to provide ride-through for critical loads.