gebhart/patrepeval huggingface dataset:
Analysis of a Simplified Hopping Robot (1991)

This article offers some analytical results concerning sim plified models of Raibert's hopper. We represent the task of achieving a recurring hopping height for an actuated "ball" robot as a stability problem in a nonlinear discrete dynamical control system. We model the properties of Raibert's control scheme in a simplified fashion and argue that his strategy leads to closed-loop dynamics governed by a well-known class of functions, the unimodal maps. The rich mathematical literature on this subject greatly advances our ability to determine the presence of an essentially globally attracting fixed point-the formal ren dering of what we intuitively mean by a "correct" strat egy. The motivation for this work is the hope that it will facilitate the development of general design principles for "dynamically dexterous" robots.
An Improved Model for Segmentation and Recognition of Fine-Grained Activities with Application to Surgical Training Tasks (2015)

Automated segmentation and recognition of fine-grained activities is important for enabling new applications in industrial automation, human-robot collaboration, and surgical training. Many existing approaches to activity recognition assume that a video has already been segmented and perform classification using an abstract representation based on spatio-temporal features. While some approaches perform joint activity segmentation and recognition, they typically suffer from a poor modeling of the transitions between actions and a representation that does not incorporate contextual information about the scene. In this paper, we propose a model for action segmentation and recognition that improves upon existing work in two directions. First, we develop a variation of the Skip-Chain Conditional Random Field that captures long-range state transitions between actions by using higher-order temporal relationships. Second, we argue that in constrained environments, where the relevant set of objects is known, it is better to develop features using high-level object relationships that have semantic meaning instead of relying on abstract features. We apply our approach to a set of tasks common for training in robotic surgery: suturing, knot tying, and needle passing, and show that our method increases micro and macro accuracy by 18.46% and 44.13% relative to the state of the art on a widely used robotic surgery dataset.
Large-Scale, Surfactant-Free, Hydrothermal Synthesis of Lithium Aluminate Nanorods:  Optimization of Parameters and Investigation of Growth Mechanism (2007)

Lithium aluminate nanorods were successfully synthesized from Al2O3 nanoparticles and lithium hydroxide by a simple, large-scale hydrothermal process without any surfactant or template. The various reaction parameters were optimized to achieve the maximum yield. The as-obtained nanorods had orthorhombic beta-lithium aluminate structure with edges in the range of 40-200 nm and lengths of 1-2 mum confirmed by SEM, TEM, XRD, and NMR. Upon calcination at 1273 K for 12 h it transformed to gamma-lithium aluminate, yet maintained the initial morphology, demonstrating the thermal stability. The ratio of lithium hydroxide to aluminum oxide showed a significant effect on the morphology as Li/Al = 1 gives "microroses", whereas Li/Al = 3 and Li/Al = 15 gave "microbricks" and "nanorods", respectively. Investigation of the mechanism showed that the nanorods were formed via a "rolling-up" mechanism. As we used all-inorganic raw materials and a simple synthetic procedure under mild conditions, the scale-up of this process for large-scale production should be very easy.
Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model (2008)

Mesenchymal stem cells (MSCs) secrete bioactive factors that exert diverse responses in vivo. In the present study, we explored mechanism how MSCs may lead to higher functional recovery in the animal stroke model. Bone marrow-derived MSCs were transplanted into the brain parenchyma 3 days after induction of stroke by occluding middle cerebral artery for 2 h. Stoke induced proliferation of resident neural stem cells in subventricular zone. However, most of new born cells underwent cell death and had a limited impact on functional recovery after stroke. Transplantation of MSCs enhanced proliferation of endogenous neural stem cells while suppressing the cell death of newly generated cells. Thereby, newborn cells migrated toward ischemic territory and differentiated in ischemic boundaries into doublecortin+ neuroblasts at higher rates in animals with MSCs compared to control group. The present study indicates that therapeutic effects of MSCs are at least partly ascribed to dual functions of MSCs by enhancing endogenous neurogenesis and protecting newborn cells from deleterious environment. The results reinforce the prospects of clinical application using MSCs in the treatment of neurological disorders.
Patterns of Fluorescent Protein Expression in Scleractinian Corals (2008)

Biofluorescence exists in only a few classes of organisms, with Anthozoa possessing the majority of species known to express fluorescent proteins. Most species within the Anthozoan subgroup Scleractinia (reef-building corals) not only express green fluorescent proteins, they also localize the proteins in distinct anatomical patterns.We examined the distribution of biofluorescence in 33 coral species, representing 8 families, from study sites on Australia's Great Barrier Reef. For 28 of these species, we report the presence of biofluorescence for the first time. The dominant fluorescent emissions observed were green (480-520 nm) and red (580-600 nm). Fluorescent proteins were expressed in three distinct patterns (highlighted, uniform, and complementary) among specific anatomical structures of corals across a variety of families. We report no significant overlap between the distribution of fluorescent proteins and the distribution of zooxanthellae. Analysis of the patterns of fluorescent protein distribution provides evidence that the scheme in which fluorescent proteins are distributed among the anatomical structures of corals is nonrandom. This targeted expression of fluorescent proteins in corals produces contrast and may function as a signaling mechanism to organisms with sensitivity to specific wavelengths of light.
ATP depletion causes translational immobilization of cell surface transferrin receptors in K562 cells (1996)

We have used quantitative fluorescence microscopy and fluorescence photobleaching recovery to examine the role of metabolic energy in the translational movement of transferrin receptors in the plasma membrane of K562 erythroleukemia cells. Cellular ATP depletion caused a significant decrease in the translational mobility of cell surface transferrin receptors and a significant increase in the number of receptors on the cell surface. ATP repletion restored receptor translational mobility and cell surface expression to control values. Inhibition of ATP hydrolases by orthovanadate also immobilized cell surface transferrin receptors and altered cell surface receptor expression, in a concentration-dependent manner. Vanadate-induced changes in receptor mobility and cell surface expression were reversible upon washing out the drug. Cellular ATP depletion did not affect the translational mobility of plasma membrane glycophorins or a fluorescent phospholipid analogue. We conclude that the translational movement of cell surface transferrin receptors specifically requires metabolic energy and ATP hydrolysis.
Pharmacokinetics and distribution of 2‐hydroxypropyl‐β‐cyclodextrin following a single intrathecal dose to cats (2019)

2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is an experimental therapy for Niemann-Pick disease type C (NPC) that reduced neuronal cholesterol and ganglioside storage, reduced Purkinje cell death, and increased lifespan in npc1-/- mice and NPC1 cats. In this study, tissue distribution was investigated in normal cats that received a single 120-mg dose of [<sup>14</sup> C]-HP-β-CD (approximately 200 μCi/cat) via the cerebellomedullary cistern (CBMC) and lumbar cistern. One cat was euthanized at each of various time points up to 24 hours postdose for subsequent processing and quantitative whole-body autoradiographic analysis. HP-β-CD-derived radioactivity absorbed from the CBMC was widely distributed to cat tissues; most tissues were observed to have reached their highest concentration at 1 hour postdose. HP-β-CD-derived radioactivity penetrated into the deeper parts of the central nervous system with the highest concentration at 4 hours (403 μg Eq/g or 0.28 mM) and remained high (49.7 μg Eq/g or 0.03 mM) at 24 hours. The relatively long half-life (11-30 hours) in cerebral ventricles and the subarachnoid space surrounding the brain and spinal cord might contribute to the efficacy of HP-β-CD in NPC1 cats. Other tissues with high concentrations of radioactivity were nasal turbinates, pituitary gland, and urinary bladder, while relatively low concentrations were observed in blood and bile.
Suppression of Thromboxane A<sub>2</sub>but Not of Systemic Prostacyclin by Controlled-Release Aspirin (1991)

Maximal inhibition of platelet thromboxane A2 production was sustained during long-term dosing with controlled-release aspirin, whereas basal prostacyclin biosynthesis fell only slightly and systemic synthesis of prostacyclin stimulated by bradykinin was preserved. Controlled-release aspirin may facilitate determination of the clinical importance of preserving prostacyclin during platelet inhibition in humans.
Rate-Distortion Optimized Motion Estimation for Error Resilient Video Coding (2006)

Rate-distortion optimized motion compensation was originally proposed to improve the source coding efficiency of low bit-rate video coding. This paper investigates the potential benefits of extensions to explicitly handle transmission over lossy networks. The important impact of appropriate motion compensation on error resilience is identified and exploited to enhance performance. The expected end-to-end distortion, rather than the source coding distortion, is employed in the rate-distortion optimization criterion. The accuracy of the distortion estimate is crucial when optimizing over the motion vectors (as compared to the less sensitive inter/intra mode decision), and is ensured here by adopting the recursive optimal per-pixel estimate (ROPE) method. The main objective is to assess the gains achievable by such source-channel motion compensation, and this is given priority over complexity considerations. Significant performance gains in simulation demonstrate the potential of rate-distortion optimized motion compensation to improve the error resilience of video coding.
[The presence of bacteriophages in human feces and their potential importance]. (2006)

Bacteriophages are widely distributed throughout the environment as well as in the bodies of humans and animals (feces, urine, saliva, sputum). Higher presence of Escherichia coli phages compared with Bacteroides fragilis and Salmonella phages was noticed in the feces of healthy human individuals and patients, mainly those with gastro-intestinal tract diseases. A strict correlation exists between the number of bacteria and of phages in the feces of healthy individuals as well as of patients with different diseases. The presence of phages in human feces correlates with the character of the coexisting disease. The frequency of phages in the feces depends on the different indicator bacterial host strains and the numbers of indicator strains. The role of bacteriophages in protecting against pathogenic microorganisms and controlling bacterial flora in the human organism is of major significance.
MACsec Layer 2 Security in HSR Rings in Substation Automation Systems (2017)

The smart-grid concept takes the communications from the enclosed and protected environment of a substation to the wider city or nationwide area. In this environment, cyber security takes a key role in order to secure the communications. The challenge is to be able to secure the grid without impacting the latency while, at the same time, maintaining compatibility with older devices and non secure services. At the lower level, added security must not interfere with the redundancy and the latency required for the real-time substation automation communications. This paper studies how to integrate IEEE MAC Security standard (MACsec) in the substation environment, especially when used in substation system communications
Effects of environmental temperature and dietary zinc on egg production performance, egg quality and antioxidant status and expression of heat-shock proteins in tissues of broiler breeders (2018)

To investigate the effects of environmental temperature and dietary Zn on egg production performance, egg quality and antioxidant status, as well as expression of heat-shock proteins (HSP) in tissues, of laying broiler breeders, we used a completely randomised design with a 2×3 factorial arrangement of treatments. The two environmental temperatures were normal (21±1°C, NT) and high (32±1°C, HT). The three dietary Zn sources were a Zn-unsupplemented basal diet (CON), and the basal diet supplemented with 110 mg Zn/kg as either the inorganic Zn sulphate (iZn) or the organic Zn proteinate with a moderate chelation strength (oZn). HT decreased (P<0·002) egg weight, laying rate, eggshell strength, thickness and weight, but increased (P≤0·05) rectal temperature, broken egg rate, misshapen egg rate, feed:egg ratio, Cu Zn superoxide dismutase activities in liver and pancreas, as well as metallothionein (MT) level in pancreas, and HSP70 mRNA levels in liver and pancreas of laying broiler breeders. Broiler breeders fed the oZn diet had higher (P<0·04) Zn content in the liver, as well as MT levels in the liver and pancreas, compared with those fed the CON diet. Under HT, broiler breeders fed the oZn diet had higher (P<0·05) Zn content in the pancreas compared with those fed the iZn and CON diets. The results from this study indicated that HT impaired egg production performance and eggshell quality possibly because of the disturbed redox balance and HSP homoeostasis, whereas the oZn is more available than the iZn for pancreatic Zn of heat-stressed laying broiler breeders.
Replication and allocation of task modules in distributed real-time systems (2002)

This paper addresses the problem of replicating and allocating periodic task modules to processing nodes (PNs) in distributed real-time systems subject to task precedence and timing constraints. The probability that all tasks can be completed before their deadlines-termed as the probability of no dynamic failure (P/sub ND/)-is used as the performance-related reliability measure. Modules which are critical in meeting task deadlines are then selected using the critical path analysis. To provide the timing correctness embedded in P/sub ND/, both original and replicated task modules are not only assigned to PNs, but also scheduled on each PN so as to meet the deadlines of all tasks. The module allocation scheme uses (1) the branch-and-bound method to implicitly enumerate all possible allocations while effectively pruning unnecessary search paths; and (2) the module scheduling scheme to schedule the modules assigned to each PN. Several numerical examples are presented to illustrate the proposed scheme.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions (2018)

The quality control testing of chemical degradations in the bio-pharmaceutical industry is currently under controversial debate. Here we have systematically applied in vitro and in vivo stress conditions to investigate the influence of protein degradation on structure-function. Extensive purification and characterization enabled identification and functional assessment of the physiological degradation of chemical modification sites in the variable complementarity-determining regions (CDRs) and conserved region of trastuzumab. We demonstrate that the degradation of the solvent-accessible residues located in the CDR and the conserved fragment crystallizable region (Fc) occurs faster in vivo (within days) compared to the levels observed for bio-process and real-time storage conditions. These results hence question the rationality of extreme monitoring of low level alterations in such chemical modifications as critical patient safety parameters in product quality control testing, given that these modifications merely mirror the natural/physiological aging process of endogenous antibodies.
Automatic classification for vulnerability based on machine learning (2013)

In order to solve the problems of traditional machine learning methods for automatic classification of vulnerability, this paper presents a novel machine learning method based on LDA model and SVM. Firstly, word location information is introduced into LDA model called WL-LDA (Weighted Location LDA), which could acquire better effect through generating vector space on themes other than on words. Secondly, a multi-class classifier called HT-SVM (Huffman Tree SVM) is constructed, which could make a faster and more stable classification by making good use of the prior knowledge about distribution of the number of vulnerabilities. Experiments show that the method could obtain higher classification accuracy and efficiency.
A Sustainable Redox‐Flow Battery with an Aluminum‐Based, Deep‐Eutectic‐Solvent Anolyte (2017)

Nonaqueous redox-flow batteries are an emerging energy storage technology for grid storage systems, but the development of anolytes has lagged far behind that of catholytes due to the major limitations of the redox species, which exhibit relatively low solubility and inadequate redox potentials. Herein, an aluminum-based deep-eutectic-solvent is investigated as an anolyte for redox-flow batteries. The aluminum-based deep-eutectic solvent demonstrated a significantly enhanced concentration of circa 3.2 m in the anolyte and a relatively low redox potential of 2.2 V vs. Li<sup>+</sup> /Li. The electrochemical measurements highlight that a reversible volumetric capacity of 145 Ah L<sup>-1</sup> and an energy density of 189 Wh L<sup>-1</sup> or 165 Wh kg<sup>-1</sup> have been achieved when coupled with a I<sub>3</sub><sup>-</sup> /I<sup>-</sup> catholyte. The prototype cell has also been extended to the use of a Br<sub>2</sub> -based catholyte, exhibiting a higher cell voltage with a theoretical energy density of over 200 Wh L<sup>-1</sup> . The synergy of highly abundant, dendrite-free, multi-electron-reaction aluminum anodes and environmentally benign deep-eutectic-solvent anolytes reveals great potential towards cost-effective, sustainable redox-flow batteries.
Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events (2010)

A low RH signal detected by EndoPAT, consistent with endothelial dysfunction, was associated with higher AE rate during follow-up. L_RHI was an independent predictor of AE. Non-invasive assessment of peripheral vascular function may be useful for the identification of patients at risk for cardiac AEs.
Green water-based silver nanoplate conductive ink for flexible printed circuit (2015)

A green water-based silver nanoplate ink was developed for printed circuit board. The growth of the nanoplates was shown by the colour change of the solution. Silver nanoplates with the side length around 20–40 nm in the ink were identified by transmission electron microscope and X-ray diffractomer. The ink patterned on the flexible substrates (polyimide) turned into conductive pattern after sintered at 300°C for 1 hour. The morphology of the conductive patterns were characterised by scanning electron microscopy. After the sintering process, the resistivity of the conductive ink was 9.43μΩ.cm, while the adhesion to the substrate reached 4 B. Thermal gravity analysis was conducted to deduce the mechanism of the sintering process and the solid content of the ink. The application of the conductive ink was also discussed in this paper.
Cell culture methods for the establishment of the NCI series of lung cancer cell lines (1996)

More than 200 human small cell lung cancer and non-small cell lung cancer cell lines were established over 15 years mainly by utilizing the serum-free, hormone and growth factor supplemented, defined media HITES and ACL4. Use of modified, established cell culture techniques such as the mechanical spillout method for the releasing of cell aggregates from tumor tissue, ficoll gradient centrifugation for the separation of tumor cells from erythrocytes and tissue debris, and an apparatue consisting of a platinum tubing attached to a suction flask for removal of spent medium have greatly contributed to the success in culturing tumor cells. Characterization of these lung cancer cell lines have extended our knowledge of lung cell biology. Studies elucidating the nutritional requirements of lung cancer cell growth may be helpful for the manipulation of these tumors in patients.
Tailoring of Grain Boundary Structure and Chemistry of Cathode Particles for Enhanced Cycle Stability of Lithium Ion Battery (2017)

The biggest challenge for the commercialization of layered structured nickel rich lithium transition metal oxide cathode is the capacity and voltage fading. Resolving this problem over the years follows an incremental progress. In this work, we report our finding of totally a new approach to revolutionize the cycle stability of aggregated cathode particles for lithium ion battery at both room and elevated temperatures. We discover that infusion of a solid electrolyte into the grain boundaries of the cathode secondary particles can dramatically enhance the capacity retention and voltage stability of the battery. We find that the solid electrolyte infused in the boundaries not only acts as a fast channel for Li ion transport, but also most importantly prevents penetration of the liquid electrolyte into the boundaries, consequently eliminating the detrimental factors that include solid-liquid interfacial reaction, intergranular cracking, and layer to spinel phase transformation. The present work, for the first time, reveals unprecedented insight as how the cathode behaves in the case of not contacting with the liquid electrolyte, ultimately points toward a general new route, via grain boundary engineering, for designing of better batteries of both solid-liquid and solid state systems.