gebhart/patrepeval huggingface dataset:
A Novel Multiobjective Cell Switch-Off Method with Low Complexity for Realistic Cellular Deployments. (2015)

Cell Switch-Off (CSO) is recognized as a promising approach to reduce the energy consumption in next-generation cellular networks. However, CSO poses serious challenges not only from the resource allocation perspective but also from the implementation point of view. Indeed, CSO represents a difficult optimization problem due to its NP-complete nature. Moreover, there are a number of important practical limitations in the implementation of CSO schemes such as the need for minimizing the real-time complexity and the number of transitions as well as handovers. This article introduces a novel approach to CSO based on multiobjective optimization that makes use of the statistical description of the service demand (known by operators). In addition, downlink and uplink coverage criteria are included and a comparative analysis between different models to characterize intercell interference is also presented to shed light on their impact on CSO. The method distinguishes itself from the other proposals in two ways: 1) The number of cell switch on/off transitions as well as handovers are minimized, and 2) the computationally-heavy part of the algorithm is executed offline, which makes its implementation feasible. The results show that the proposed scheme achieves substantial energy savings in small cell deployments where traffic is highly unbalanced, with neither compromising the Quality-of-Service (QoS) nor requiring heavy real-time processing.
Leptin Receptor Activation Depends on Critical Cysteine Residues in Its Fibronectin Type III Subdomains (2005)

The leptin receptor (LR) complex is composed of a single subunit belonging to the class I cytokine receptor family and exists as a preformed complex. The extracellular portion contains two cytokine receptor homology (CRH) domains, separated by an Ig-like domain and followed by two membrane-proximal fibronectin type III (FNIII) domains. The mechanisms underlying ligand-induced receptor activation are still poorly understood. LRs can exist as disulfide-linked dimers at the cell surface, even in the absence of leptin. We evaluated the role of the two unpaired cysteine residues (Cys-672 and Cys-751) in the FNIII domains in receptor clustering, leptin binding, and biological activity. Although mutation of cysteine on position 751 to serine has hardly any effect on ligand binding and receptor activation, the C672S mutant exhibits a marked reduction in STAT3-dependent signaling. The double mutant was completely devoid of biological activity, although leptin binding remained unaffected. Mutation of both residues resulted in complete loss of disulfide bridge formation of FNIII domains in solution. In contrast, no difference was observed in ligand-independent oligomerization of the membrane-bound receptor, suggesting a role for cysteines in the CRH2 domain in formation of the preformed LR complex. We propose a model wherein leptin-induced clustering of two preformed dimers forms the activated LR complex. Disulfide bridge formation involving Cys-672 and Cys-751 may be necessary for JAK activation and hence signaling.
Technique for in-situ measurements of polarization mode dispersion (2004)

A nondisruptive PMD measurement technique (utilizing the sidebands of working channels) is demonstrated, compared to the Mueller matrix method, and applied to a 43Gb/s field-installed system. Correlation between differential group delay and bit-error rate is observed.
SWAG: Item Recommendations using Convolutions on Weighted Graphs (2019)

Recent advancements in deep neural networks for graph-structured data have led to state-of-the-art performance on recommender system benchmarks. In this work, we present a Graph Convolutional Network (GCN) algorithm SWAG (Sample Weight and AGgregate), which combines efficient random walks and graph convolutions on weighted graphs to generate embeddings for nodes (items) that incorporate both graph structure as well as node feature information such as item-descriptions and item-images. The three important SWAG operations that enable us to efficiently generate node embeddings based on graph structures are (a) Sampling of graph to homogeneous structure, (b) Weighting the sampling, walks and convolution operations, and (c) using AGgregation functions for generating convolutions. The work is an adaptation of graphSAGE over weighted graphs. We deploy SWAG at Target and train it on a graph of more than 500K products sold online with over 50M edges. Offline and online evaluations reveal the benefit of using a graph-based approach and the benefits of weighing to produce high quality embeddings and product recommendations.
Nonmaximally Entangled States: Production, Characterization, and Utilization (1999)

Using a spontaneous-down-conversion photon source, we produce true nonmaximally entangled states, i.e., without the need for postselection. The degree and phase of entanglement are readily tunable, and are characterized both by a standard analysis using coincidence minima, and by quantum state tomography of the two-photon state. Using the latter, we experimentally reconstruct the reduced density matrix for the polarization. Finally, we use these states to measure the Hardy fraction, obtaining a result that is $122\ensuremath{\sigma}$ from any local-realistic result.
Study of Free Piston Vuilleumier Heat Pump. Basic Performance Analysis. (1997)

A linear analysis model for a free piston Vuilleumier heat pump(FPVM)was constructed to derive closed from solutions for the operating frequency, phase angle and displacer strokes during self-excited operation and forced oscillation. Using the linear analysis, conditions for self-excited operation and the effects of connecting the hot and the cold displacers by a spring on the dynamic motion of the displacers and the FPVM performance were investigated. Energy flow in the FPVM was also pbtained. A simple 2nd order isothermal simulation combined with the linear analysis was developed which enabled calculation of the FPVM performance characteristics. It was found that the simulation results were qualitatively in good agreement with the experimental results during self-excited operation. Simulation was used to calculate the dependence of the dynamic motion of the displacers and the FPVM performance on the spring constants, displacer masses and damping coefficients.
The Growth Response of Erythrocyte Production to Increased Dense Condition (2011)

Abstract Abstract 4812 Erythroid precursors proliferate, differentiate, and enucleate in the bone marrow niches called erythroblastic islands in contact with macrophages. However, the cell-to-cell communication between erythroblasts which are undergoing terminal maturation leading to enucleation is not well known. Moreover, the cell-to-cell interaction at a terminal erythroblast maturation stage was hardly detected in conventional suspension culture systems due to cell surface characteristics of electrostatic repulsion. To elucidate the communication between late maturing erythroblasts, erythroid cells, which were derived from human CD34+ cells, were cultured at conventional or supra-optimal densities. Surprisingly, the final yields of red blood cells (RBCs) were significantly increased in supra-optimal culture density, even in the absence of feeder stromal cells and serum or plasma. Also observed were increases in the rates of cell survival, expansion, and enucleation. Contact between cells observed in these supra-optimal cultures was associated with increases in adhesion-related signaling proteins (150 kDa and 123 kDa), the latter of which was previously unknown to be involved in erythropoiesis. The cultured erythroid cells showed erythropoiesis specific markers such as CD71, GPA, GATA-1 and b-globin. Therefore, we firstly elucidated that the erythroid cells which were in the final maturation step can communicate each other and affect their survival and maturation including enucleation without the help of macrophages. Also, the increased attachments between erythroid cells evoked adhesion-related signals. We anticipate that the culture of these cells at supra-optimal density may enhance in vitro RBC production for human transfusion. Disclosures: No relevant conflicts of interest to declare.
Reinventing Butyl Rubber for Stretchable Electronics (2016)

The development of stretchable electronic devices that are soft and conformable has relied heavily on a single material—polydimethylsiloxane—as the elastomeric substrate. Although polydimethylsiloxane has a number of advantageous characteristics, its high gas permeability is detrimental to stretchable devices that use materials sensitive to oxygen and water vapor, such as organic semiconductors and oxidizable metals. Failing to protect these materials from atmosphere‐induced decomposition leads to premature device failure; therefore, it is imperative to develop elastomers with gas barrier properties that enable stretchable electronics with practical lifetimes. Here, butyl rubber—a material with an intrinsically low gas permeability traditionally used in the innerliners of tires to maintain air pressure—is reinvented for stretchable electronics. This new material is smooth and optically transparent, possesses the low gas permeability typical of butyl rubber, and vastly outperforms polydimethylsiloxane as an encapsulating barrier to prevent the atmospheric degradation of sensitive electronic materials and the premature failure of functioning organic devices. The merits of transparent butyl rubber presented here position this material as an important counterpart to polydimethylsiloxane that will enable future generation stretchable electronics.
Propagation of a Human Herpesvirus from AIDS-Associated Kaposi's Sarcoma (1997)

A herpesvirus with DNA sequences identical to those of KSHV can be propagated from skin lesions of patients with AIDS-associated Kaposi's sarcoma.
Safe extension of red blood cell storage life at 4{degree}C (1996)

The project sought to develop methods to extend the storage life of red blood cells. Extended storage would allow donor to self or autologous transfusion, expand and stabilize the blood supply, reduce the cost of medical care and eliminate the risk of transfusion related infections, including a spectrum of hepatitides (A, B and C) and HIV. The putative cause of red blood cell spoilage at 4 C has been identified as oxidative membrane damage resulting from deoxyhemoglobin and its denaturation products including hemichrome, hemin and Fe{sup 3+}. Trials with carbon monoxide, which is a stabilizer of hemoglobin, have produced striking improvement of red blood cell diagnostics for cells stored at 4 C. Carbonmonoxy hemoglobin is readily converted to oxyhemoglobin by light in the presence of oxygen. These findings have generated a working model and an approach to identify the best protocols for optimal red cell storage and hemoglobin regeneration.
Preparation of Cardiac Extracellular Matrix from an Intact Porcine Heart (2009)

Whole organ engineering would benefit from a three-dimensional scaffold produced from intact organ-specific extracellular matrix (ECM). The microenvironment and architecture provided by such a scaffold would likely support site-appropriate cell differentiation and spatial organization. The methods to produce such scaffolds from intact organs require customized decellularization protocols. In the present study, intact adult porcine hearts were successfully decellularized in less than 10 h using pulsatile retrograde aortic perfusion. Serial perfusion of an enzymatic, nonionic detergent, ionic detergent, and acid solution with hypotonic and hypertonic rinses was used to systematically remove cellular content. The resultant cardiac ECM retained collagen, elastin, and glycosaminoglycans, and mechanical integrity. Cardiac ECM supported the formation of organized chicken cardiomyocyte sarcomere structure in vitro. The intact decellularized porcine heart provides a tissue engineering template that may be beneficial for future preclinical studies and eventual clinical applications.
Advanced Drilling Simulation Environment for Testing New Drilling Automation Techniques and Practices (2012)

Summary Newly developed drilling automation systems locate a computer interface between commands issued by the driller and instructions transmitted to the drilling machinery. Such functions are capable of faster and more precise control than can be achieved by an unaided operator and thus can help drilling within narrow margins. To ensure that these systems work properly in all circumstances, an advanced drilling simulator has been developed to enable testing under a wide range of simulated conditions. The environment described in this paper uses hardware in the loop (HIL) simulation to verify that the automation techniques being tested respond correctly in real time. Rigorously validated physical models of the drilling process simulate the response of the well to the commands given to the drilling machines. Abnormal drilling conditions (e.g., packoffs, kicks) and equipment or machine-related problems (e.g., plugged nozzles, power shortage) are convincingly recreated. The drilling simulator models the behavior of surface equipment such as the activation of gate valves to line up different pits or the flow in the mud return. It simulates changes in the drilling fluid properties when mixing additives to the mud. It is therefore possible to focus training sessions on cooperation between different groups at the wellsite. This is particularly useful when planning the introduction of drilling automation that involves new work procedures as a result of automation and adaptation of the drilling team to a new operational environment. Drilling operations are becoming more and more complex. Automation has the potential to provide large improvements in efficiency and safety, but automation technologies must be implemented correctly at the workplace. Just as the aviation industry has used simulated environments for decades, drilling simulation environments are the key to the safe and successful implementation of drilling automation and the development of crew skills to face future challenges.
Discovery and Validation of Plasma-Protein Biomarker Panels for the Detection of Colorectal Cancer and Advanced Adenoma in a Danish Collection of Samples from Patients Referred for Diagnostic Colonoscopy (2016)

These results suggest that the development of blood-based aids to colorectal cancer detection and diagnosis is feasible.
Human renin inhibitors (1985)

Conference Article| December 01 1985 Human renin inhibitors BRENDA J. LECKIE; BRENDA J. LECKIE *M.R.C. Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT, U.K. Search for other works by this author on: This Site PubMed Google Scholar MICHAEL SZELKE; MICHAEL SZELKE †Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS, U.K. Search for other works by this author on: This Site PubMed Google Scholar BUTRUS ATRASH; BUTRUS ATRASH †Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS, U.K. Search for other works by this author on: This Site PubMed Google Scholar SHEILA R. BEATTIE; SHEILA R. BEATTIE *M.R.C. Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT, U.K. Search for other works by this author on: This Site PubMed Google Scholar ALLAN HALLETT; ALLAN HALLETT †Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS, U.K. Search for other works by this author on: This Site PubMed Google Scholar DAVID M. JONES; DAVID M. JONES †Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS, U.K. Search for other works by this author on: This Site PubMed Google Scholar GORDON D. McINTYRE; GORDON D. McINTYRE *M.R.C. Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT, U.K. Search for other works by this author on: This Site PubMed Google Scholar JAVIER SUERIAS; JAVIER SUERIAS †Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS, U.K. Search for other works by this author on: This Site PubMed Google Scholar DAVID J. WEBB DAVID J. WEBB *M.R.C. Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1985) 13 (6): 1029–1032. https://doi.org/10.1042/bst0131029 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation BRENDA J. LECKIE, MICHAEL SZELKE, BUTRUS ATRASH, SHEILA R. BEATTIE, ALLAN HALLETT, DAVID M. JONES, GORDON D. McINTYRE, JAVIER SUERIAS, DAVID J. WEBB; Human renin inhibitors. Biochem Soc Trans 1 December 1985; 13 (6): 1029–1032. doi: https://doi.org/10.1042/bst0131029 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1985 Biochemical Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.
A New Fuzzless Seed Locus in an Upland Cotton (&lt;i&gt;Gossypium hirsutum&lt;/i&gt; L.) Mutant (2012)

Various fiber mutants of cotton have been reported since 1920. Two of the best characterized mutants are the naked seed loci, N1N1 and n2n2. Recently, a naked-tufted mutant called 9023 nt4 was developed from the cultivar SC 9023 through chemical mutagenesis. The mutant was tested to determine if it was allelic to either N1, or n2 or was a unique mutant in a new uncharacterized locus. In 1999, one M3 plant from SC 9023 with tufted partially naked seed coat (fuzzless) was identified. In 2004, 2006, and 2007 (Lubbock, TX), 2007 (College Station, TX), and 2011 (Stoneville, MS), the homozygous naked seed mutant was evaluated with the non-mutated wild type parent (SC 9023) in rep-licated trials for agronomic and fiber traits. Crosses between the mutant and the wild type was made at Stoneville, MS in 2009. The F2 of this cross segregated in a 3 fuzzy: 1 fuzzless ratio indicating that the fuzzless trait in the mutant is controlled by a recessive locus. Allelism tests with N1N1, n2n2 and n3n3, lint percent, and fiber trait data indicated that the new locus in the mutant differs from the previously characterized fuzzless seed alleles in that it does not appear to decrease lint percent. We have putatively designated this gene nt4nt4 .
An efficient HEVC to H.264/AVC transcoding system (2015)

The latest High Efficiency Video Coding (HEVC) achieves significant compression performance improvement over Advanced Video Coding (AVC). The high compression efficiency of HEVC together with the wide availabilities of H.264/AVC decoders necessitates transcoding between these two technologies. In this paper, we propose a novel algorithm for software-based HEVC to H.264/AVC transcoding. By utilizing the information extracted from the input HEVC stream, the transcoding process can be accelerated with relatively minor compression efficiency loss. Experiment results show that the proposed transcoding algorithm can save around 60% of the time cost of re-encoding process compared with x264, one of the most widely used H.264 encoders, with very small loss of compression performance.
Versatile and Scalable Method for Producing <i>N</i>-Functionalized Imidazoles (2011)

Imidazolate salts are powerful and versatile starting materials that can be used to generate many useful compounds. To this end, a method for producing sodium imidazolate (NaIm) from only commodity starting materials has been developed. NaIm was directly produced at a scale of ∼400 g via the neutralization of molten imidazole by NaOH, followed by dehydration. The NaIm product was then utilized as a starting material to produce 20 different N-functionalized imidazole and bis(imidazole) compounds, with the application of a common procedure involving minimal solvent volumes and straightforward purification via flash chromatography and solvent evaporation. Generating N-functionalized imidazoles “on demand” from NaIm and alkyl halides (or similar compounds) can eliminate the need for hazardous starting materials such as NaH and anhydrous solvents that have typically been employed in their synthesis. This method may ultimately enhance the availability of N-functionalized imidazoles for a variety of research and commercial applications.
A 3D Feature Descriptor Recovered from a Single 2D Palmprint Image (2016)

Design and development of efficient and accurate feature descriptors is critical for the success of many computer vision applications. This paper proposes a new feature descriptor, referred to as DoN, for the 2D palmprint matching. The descriptor is extracted for each point on the palmprint. It is based on the ordinal measure which partially describes the difference of the neighboring points' normal vectors. DoN has at least two advantages: 1) it describes the 3D information, which is expected to be highly stable under commonly occurring illumination variations during contactless imaging; 2) the size of DoN for each point is only one bit, which is computationally simple to extract, easy to match, and efficient to storage. We show that such 3D information can be extracted from a single 2D palmprint image. The analysis for the effectiveness of ordinal measure for palmprint matching is also provided. Four publicly available 2D palmprint databases are used to evaluate the effectiveness of DoN, both for identification and the verification. Our method on all these databases achieves the state-of-the-art performance.
Mutational Analysis of the GB Virus B Internal Ribosome Entry Site (2000)

GB virus B (GBV-B) is a recently discovered hepatotropic flavivirus that is distantly related to hepatitis C virus (HCV). We show here that translation of its polyprotein is initiated by internal entry of ribosomes on GBV-B RNA. We analyzed the translational activity of dicistronic RNA transcripts containing wild-type or mutated 5' nontranslated GBV-B RNA (5'NTR) segments, placed between the coding sequences of two reporter proteins, in vitro in rabbit reticulocyte lysate and in vivo in transfected BT7-H cells. We related these results to a previously proposed model of the secondary structure of the GBV-B 5'NTR (M. Honda, et al. RNA 2:955-968, 1996). We identified an internal ribosome entry site (IRES) bounded at its 5' end by structural domain II, a location analogous to the 5' limit of the IRES in both the HCV and pestivirus 5'NTRs. Mutational analysis confirmed the structure proposed for domain II of GBV-B RNA, and demonstrated that optimal IRES-mediated translation is dependent on each of the putative RNA hairpins in this domain, including two stem-loops not present in the HCV or pestivirus structures. IRES activity was also absolutely dependent on (i) phylogenetically conserved, adenosine-containing bulge loops in domain III and (ii) the primary nucleotide sequence of stem-loop IIIe. IRES-directed translation was inhibited by a series of point mutations predicted to stabilize stem-loop IV, which contains the initiator AUG codon in its loop segment. A reporter gene was translated most efficiently when fused directly to the initiator AUG codon, with no intervening downstream GBV-B sequence. This finding indicates that the 3' limit of the GBV-B IRES is at the initiator AUG and that it does not require downstream polyprotein-coding sequence as suggested for the HCV IRES. These results show that the GBV-B IRES, while sharing a common general structure, differs both structurally and functionally from other flavivirus IRES elements.