gebhart/patrepeval huggingface dataset:
Genipin‐crosslinked gelatin microspheres as a drug carrier for intramuscular administration: <i>In vitro</i> and <i>in vivo</i> studies (2003)

Gelatin microspheres have been widely evaluated as a drug carrier. Nevertheless, gelatin dissolves rather rapidly in aqueous environments, making the use of the polymer difficult for the production of long-term delivery systems. This adverse aspect requires the use of a crosslinking agent in forming nonsoluble networks in microspheres. However, the use of crosslinking agents such as formaldehyde and glutaraldehyde can lead to toxic side effects owing to residual crosslinkers. In an attempt to overcome this problem, a naturally occurring crosslinking agent (genipin) was used to crosslink gelatin microspheres as a biodegradable drug-delivery system for intramuscular administration. Glutaraldehyde was used as a control. In the in vitro study, the morphology, dynamic swelling, and antienzymatic degradation of test microspheres were evaluated. In the in vivo study, the biocompatibility and degradability of test microspheres were implanted in the skeletal muscle of a rat model via intramuscular injection. The results obtained in the study suggested that crosslinking of gelatin microspheres with glutaraldehyde or genipin may produce distinct crosslinking structures. The water transport mechanism in both the glutaraldehyde- and genipin-crosslinked gelatin microspheres exhibit anomalous behavior ranging from Fickian to Case-II extremes. The increase of the swelling diameter for the genipin-crosslinked microspheres was significantly less than that observed for the glutaraldehyde-crosslinked microspheres. In the animal study, it was found that the degree in inflammatory reaction for tissues implanted with the genipin-crosslinked microspheres was significantly less than that implanted with the glutaraldehyde-crosslinked microspheres. Additionally, the degradation rate of the genipin-crosslinked microspheres was significantly slower than their glutaraldehyde-crosslinked counterparts. These results indicated that the genipin-crosslinked gelatin microspheres may be used as a long-acting drug carrier for intramuscular administration.
CrowdStudy (2013)

While traditional usability testing methods can be both time consuming and expensive, tools for automated usability evaluation tend to oversimplify the problem by limiting themselves to supporting only certain evaluation criteria, settings, tasks and scenarios. We present CrowdStudy, a general web toolkit that combines support for automated usability testing with crowdsourcing to facilitate large-scale online user testing. CrowdStudy is based on existing crowdsourcing techniques for recruiting workers and guiding them through complex tasks, but implements mechanisms specifically designed for usability studies, allowing testers to control user sampling and conduct evaluations for particular contexts of use. Our toolkit provides support for context-aware data collection and analysis based on an extensible set of metrics, as well as tools for managing, reviewing and analysing any collected data. The paper demonstrates several useful features of CrowdStudy for two different scenarios, and discusses the benefits and tradeoffs of using crowdsourced evaluation.
MUSIC, maximum likelihood and Cramer-Rao bound: further results and comparisons (2003)

A number of results have been presented recently on the statistical performance of the multiple signal characterization (MUSIC) and the maximum-likelihood (ML) estimators for determining the direction of arrival of narrowband plane waves using sensor arrays and the related problem of estimating the parameters of superimposed signals from noisy measurements. It is shown that in the class of weighted MUSIC estimators, the unweighted MUSIC achieves the best performance (i.e. the minimum variance of estimation errors) in large samples. The covariance matrix of the ML estimator is derived, and detailed analytic studies of the statistical efficiency of MUSIC and ML estimators are presented. These studies include performance comparisons of MUSIC and MLE with each other as well as with the ultimate performance corresponding to the Cramer-Rao bound (CRB).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Computation Offloading for Frame-Based Real-Time Tasks under Given Server Response Time Guarantees (2014)

Computation offloading has been adopted to improve the performance of embedded systems by offloading the computation of some tasks, especially computation-intensive tasks, to servers or clouds. This paper explores computation offloading for real-time tasks in embedded systems, provided given response time guarantees from the servers, to decide which tasks should be offloaded to get the results in time. We consider frame-based real-time tasks with the same period and relative deadline. When the execution order of the tasks is given, the problem can be solved in linear time. However, when the execution order is not specified, we prove that the problem is NP-complete. We develop a pseudo-polynomial-time algorithm for deriving feasible schedules, if they exist. An approximation scheme is also developed to trade the error made from the algorithm and the complexity. Our algorithms are extended to minimize the period/relative deadline of the tasks for performance maximization. The algorithms are evaluated with a case study for a surveillance system and synthesized benchmarks.
Electrochemical CO<sub>2</sub> reduction on Cu<sub>2</sub>O-derived copper nanoparticles: controlling the catalytic selectivity of hydrocarbons (2014)

The catalytic activity and hydrocarbon selectivity in electrochemical carbon dioxide (CO2) reduction on cuprous oxide (Cu2O) derived copper nanoparticles is discussed. Cuprous oxide films with [100], [110] and [111] orientation and variable thickness were electrodeposited by reduction of copper(ii) lactate on commercially available copper plates. After initiation of the electrochemical CO2 reduction by these oxide structures, the selectivity of the process was found to largely depend on the parent Cu2O film thickness, rather than on the initial crystal orientation. Starting with thin Cu2O films, besides CO and hydrogen, selective formation of ethylene is observed with very high ethylene-to-methane ratios (∼8 to 12). In addition to these products, thicker Cu2O films yield a remarkably large amount of ethane. Long term Faradaic efficiency analysis of hydrocarbons shows no sign of deactivation of the electrodes after 5 hours of continuous experiment. Online mass spectroscopy studies combined with X-ray diffraction data suggest the reduction of the Cu2O films in the presence of CO2, generating a nanoparticulate Cu morphology, prior to the production of hydrogen, CO, and hydrocarbons. Optimizing coverage, number density and size of the copper nanoparticles, as well as local surface pH, may allow highly selective formation of the industrially important product ethylene.
Hormonal control of muscle growth (1987)

In muscle of whole animals, pituitary growth hormone, the thyroid hormones, and insulin are major growth-promoting hormones, and the glucocorticoids have significant catabolic actions. At the cellular level the primary anabolic hormones for cultured myoblasts are the somatomedins (insulin-like growth factors) and fibroblast growth factor. In these cells physiological concentrations of growth hormone, thyroid hormones, and insulin have no growth-promoting effect; some of the reported actions of insulin probably result from cross-reaction with the somatomedin receptor. Results with purified proteins do not support the view that mitogens block myoblast differentiation; transforming growth factor-beta and interferon are nonmitogenic proteins that inhibit differentiation, insulin-like growth factors are mitogens that stimulate differentiation, and fibroblast growth factor is the only purified mitogen that inhibits differentiation. At least six serum-free media have now been devised for the growth of various kinds of muscle cells under closely defined conditions.
Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease (2017)

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that includes Crohn's disease (CD) and ulcerative colitis (UC). Homeostasis of various regulatory factors involved with intestinal immunity is disrupted in IBD, including the intestinal epithelial barrier, macrophages, and cellular mediators such as cytokines and chemokines. No successful treatment is currently available for the management of IBD. Natural products and herbal medicines have exhibited efficacy for UC and CD in experimental models and clinical trials with the following activities: (1) maintenance of integrity of the intestinal epithelial barrier, (2) regulation of macrophage activation, (3) modulation of innate and adaptive immune response, and (4) inhibition of TNF-α activity. Here, we discuss the major factors involved in the pathogenesis of IBD and the current development of natural products and herbs for the treatment of IBD.
Hypoxia Inducible Factor-1&#945;, Endothelial Progenitor Cells, Monocytes,Cardiovascular Risk, Wound Healing, Cobalt and Hydralazine:A Unifying Hypothesis (2008)

Bone marrow-derived mononuclear cells differentiate into endothelial cells in adult animals, including humans. These cells, endothelial progenitor cells (EPCs), play central roles in neovascularization in a variety of physiological and pathological processes. EPCs numbers are clinically relevant; in patients with vascular disease, EPC numbers are predictive of hard clinical endpoints and correlate with vascular health in patients without manifest atherosclerosis. EPCs express CXCR4 which allows homing to sites of neovascularization. The homing signal released by the target tissues is SDF-1 which is the ligand for CXCR4. With release of SDF-1 and reversal of the marrow/periphery gradient, EPCs are mobilized to the periphery where they are recruited to SDF-1 expressing tissues. The SDF-1/CXCR4 axis is the final common pathway for EPC mobilization by hypoxia, angiogenic peptides and G-CSF. Expression of SDF-1 in target tissues and CXCR4 in EPCs as well as angiogenic cytokines such as VEGF are regulated by hypoxia inducible factor-1 alpha (HIF-1 alpha). This paper discusses evidence suggesting that depressed HIF-1 alpha-mediated gene programming is the most fundamental of all cardiovascular risk factors and discusses the manipulation of this system with existing drugs such as cobalt or hydralazine. By stabilizing HIF-1 alpha protein, these compounds will enhance EPC mobilization and function, thereby improving cardiovascular health overall. This paper discusses why previous studies with EPC transplantation or mobilization with G-CSF have had negative results and proposes the use of Cobalt and Hydralazine to enhance EPC function to overcome the dysfunctional EPC phenotype that is seen in patients with vascular disease or cardiovascular risk factors.
Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. (1996)

The ability of neurotrophins to modulate the survival and differentiation of neuronal populations involves the Trk/MAP (mitogen-activated protein kinase) kinase signaling pathway. More recently, neurotrophins have also been shown to regulate synaptic transmission. The synapsins are a family of neuron-specific phosphoproteins that play a role in regulation of neurotransmitter release, in axonal elongation, and in formation and maintenance of synaptic contacts. We report here that synapsin I is a downstream effector for the neurotrophin/Trk/MAP kinase cascade. Using purified components, we show that MAP kinase stoichiometrically phosphorylated synapsin I at three sites (Ser-62, Ser-67, and Ser-549). Phosphorylation of these sites was detected in rat brain homogenates, in cultured cerebrocortical neurons, and in isolated presynaptic terminals. Brain-derived neurotrophic factor and nerve growth factor upregulated phosphorylation of synapsin I at MAP kinase-dependent sites in intact cerebrocortical neurons and PC12 cells, respectively, while KCl- induced depolarization of cultured neurons decreased the phosphorylation state at these sites. MAP kinase-dependent phosphorylation of synapsin I significantly reduced its ability to promote G-actin polymerization and to bundle actin filaments. The results suggest that MAP kinase-dependent phosphorylation of synapsin I may contribute to the modulation of synaptic plasticity by neurotrophins and by other signaling pathways that converge at the level of MAP kinase activation.
A novel herpes simplex virus 1 gene, UL43.5, maps antisense to the UL43 gene and encodes a protein which colocalizes in nuclear structures with capsid proteins (1996)

An open reading frame mapping antisense to the UL43 gene of herpes simplex virus 1 encodes a protein with an apparent Mr of 38,000. The protein was detected in wild-type-infected cells with rabbit monospecific polyclonal antibody directed against a fusion protein containing all of the sequences encoded by the open reading frame. The antibody did not react with mutants from which the open reading frame was deleted. Expression of this gene, designated UL43.5, was grossly decreased or abolished in infected cells incubated in medium containing inhibitory concentrations of phosphonoacetic acid, suggesting that it is regulated as a gamma gene. UL43.5 is dispensable in cell culture. UL43.5 protein colocalized with the major capsid protein (infected cell protein 5) and the capsid scaffolding proteins (infected cell protein 35) in nuclear structures situated at the periphery of the nucleus. The predicted amino acid sequence indicates that the UL43.5 protein is a highly hydrophilic protein. The colocalization of UL43.5 protein with capsid proteins in discrete nuclear structures suggests that the former may be involved in assembly of viral particles in an accessory role in cells in culture.
Machine Learning Refined (2020)

With its intuitive yet rigorous approach to machine learning, this text provides students with the fundamental knowledge and practical tools needed to conduct research and build data-driven products. The authors prioritize geometric intuition and algorithmic thinking, and include detail on all the essential mathematical prerequisites, to offer a fresh and accessible way to learn. Practical applications are emphasized, with examples from disciplines including computer vision, natural language processing, economics, neuroscience, recommender systems, physics, and biology. Over 300 color illustrations are included and have been meticulously designed to enable an intuitive grasp of technical concepts, and over 100 in-depth coding exercises (in Python) provide a real understanding of crucial machine learning algorithms. A suite of online resources including sample code, data sets, interactive lecture slides, and a solutions manual are provided online, making this an ideal text both for graduate courses on machine learning and for individual reference and self-study.
Human  -defensin 3 promotes NF- B-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck (2010)

The microenvironment of aerodigestive cancers contains tumor-promoting inflammatory signals often involved in innate immunity. The epithelial malignancy, squamous cell carcinoma of the head and neck (SCCHN), is characterized by secretion of inflammatory mediators that can promote tumorigenesis and lymph node metastasis. Human β-defensin (hBD) 3 is one such antimicrobial mediator of innate immunity produced by squamous epithelial cells in response to tissue damage and inflammation. Here, we hypothesized that the observed overexpression of hBD3 in SCCHN may have a tumor-promoting effect or contribute to nodal metastasis, which has previously been linked to chemokine receptor (CCR) 7 overexpression. Indeed, treatment of non-metastatic SCCHN cells with hBD3 induced surface CCR7 expression and migration toward its ligand, CCL19. The hBD3-induced CCR7 upregulation in SCCHN cells was significantly reduced by inhibition of nuclear factor (NF)-κB, an inflammatory transcription factor known to influence CCR7 expression. Moreover, hBD3 stimulation provided anti-apoptotic signals to SCCHN cells, as evidenced by tumor resistance to cisplatin-induced cell death, which was regulated by phosphoinositide-3-kinase/Akt activation. Interestingly, the observed hBD3-mediated effects were not dependent on G-protein coupled receptors or toll-like receptors, as has been previously published, but hBD3 was internalized through endocytosis, allowing intracellular signal transduction. Our findings suggest that hBD3 represents a novel NF-κB-regulated mediator of CCR7 expression and anti-apoptotic pathways, which may be exploited by developing SCCHN tumors to enhance their survival and metastasis.
Immunohistochemical analysis of brainstem lesions in infantile spasms (2000)

Whether the cerebral or subcortical lesions are involved in the pathogenesis in infantile spasms (IS) remains to be determined. To investigate the functional lesions of the subcortical structures in IS, the brainstem expression of neurotransmitters, neuropeptides and calcium-binding proteins in IS autopsy cases of lissencephaly and of perinatal hypoxic ischemic encephalopathy (HIE/IS) was investigated. The IS patients consisted of four subjects each of lissencephaly and HIE. They suffered from both West and Lennox-Gastaut syndromes. The healthy and disease controls were composed of four subjects without neuromuscular disorders and six cases of HIE (HIE/C), neither of whom had the epileptic syndrome. In these subjects the expressions of tryptophan hydroxylase (TrH), tyrosine hydroxylase (TH), parvalbumin (PV), methionine-enkephalin (ME) and substance P (SP) were immunohistochemically determined in serial sections of the midbrain, pons and medulla oblongata. The immunoreactivity of neurons and neuronal processes for TH was altered in the mesencephalic periaqueductal gray matter, locus ceruleus, and dorsal vagal nucleus in the patients. The HIE/IS cases showed reduced TrH-immunoreactivity in the medullary raphe nuclei. The brainstem auditory tract was poorly discernible on anti-PV immunostaining in the IS patients. The immunoreactivity for ME in the spinal trigeminal nucleus was severely affected in the IS patients, while that for SP was comparatively well preserved. It is suggested that the presence of common brainstem lesions in IS is irrespective of etiologies. It is intriguing that some of the changes seemed to be interrelated with the neurophysiological abnormalities being reported in IS patients.
A survey on the application of Neural Networks in the safety assessment of oil and gas pipelines (2014)

Pipeline systems are an essential component of the oil and gas supply chain today. Although considered among the safest transportation methods, pipelines are still prone to failure due to corrosion and other types of defects. Such failures can lead to serious accidents resulting in big losses to life and the environment. It is therefore crucial for pipeline operators to reliably detect pipeline defects in an accurate and timely manner. Because of the size and complexity of pipeline systems, however, relying on human operators to perform the inspection is not possible. Automating the inspection process has been an important goal for the pipeline industry for a number of years. Significant progress has been made in that regard, and available techniques combine analytical modeling, numerical computations, and machine learning. This paper presents a survey of state-of-the-art methods used to assess the safety of the oil and gas pipelines. The paper explains the principles behind each method, highlights the setting where each method is most effective, and shows how several methods can be combined to achieve a higher level of accuracy.
Ammonolysis of esters of hydroxybenzoic acids on a boron phosphate catalyst (1987)

In this investigation boron phosphate catalyst was used for ammonolysis of methyl and ethyl esters of salicylic and 4-hydroxybenzoic acids. It was shown that ammonolysis of methyl and ethyl esters of salicylic and 4-hydroxybenzoic acids in presence of boron phosphate catalyst at a ratio of 3-7 moles of ammonia per mole of ester in a contact time of 1-5 sec at 380-400/sub 0/ can be used for obtaining o- and p- hydroxybenzonitriles in yields of over 90% of the theoretical.
Coulomb force virtual space structures (2006)

Recently, several uses for intercraft Coulomb forces have been explored. Proposed applications have ranged from creating static formations of many spacecraft to steerable nanosat deployment systems. This paper considers the use of Coulomb forces for creating space structures. Un-like conventional space structures, these ”virtual space structures ” have no physical connections. Instead, they are held together by maintaining specific charges at their node points. This form of structure is thus readily ex-pandable, can be reconfigured to different shapes, and is easily deployed. Fundamental concepts are covered in conjunction with a control law illustrating the ability to form a structure with conventional stiffness and damping coefficients that can be actively modified.
10-GHz return-to-zero pulse source tunable in wavelength with a single- or multiwavelength output based on four-wave mixing in a newly developed highly nonlinear fiber (2001)

In this letter, a novel scheme for a wavelength-tunable pulse source (WTPS) is proposed and characterized. It is based on four-wave mixing (FWM) in a newly developed highly nonlinear fiber between a return-to-zero (RZ) pulsed signal at a fixed wavelength and a continuous wave probe tunable in wavelength. The corresponding FWM product acts as the WTPS, and is implemented in a 10-Gb/s, 160-km transmission experiment and in a 40-Gb/s multiplexing/demultiplexing experiment. The scheme can be expanded to a multiwavelength WTPS, which is demonstrated for two wavelengths. The introduced penalty using the WTPS compared to the original RZ pulses is negligible.
Improved hydrolysis kinetic model for batch anaerobic digestion of organic solid waste (2007)

In this paper, improved first-order hydrolysis models of flat, cylindrical and spherical organic solid waste were formulated and established by adding the idea of surface area to the traditional first-order model. Comparison of the results shows that the flat particulate model is the same as the traditional first-order model. However, the relationships between the hydrolytic rates of the cylindrical and spherical particulate models with no hydrolyzed particulate organic matter concentration do not comply with first-order reaction dynamics, but are in direct proportion with the power of 3/2 and 5/3 of the particulate organic matter concentration, respectively, and are related to the initial particulate organic matter concentration. The hydrolytic rate constants of the traditional first-order model, the cylindrical model and the spherical model are 0.2493, 0.5378 and 0.6741d-1 based on experimental data. The results of model prediction and deviation analysis indicate that the shapes of organic solid waste are close to cylinders or spheres. Compared with the traditional first-order model, the improved first-order hydrolytic model can better predict the concentration of organic substances in the reactor.