gebhart/patrepeval huggingface dataset:
Multicore Fiber Technology (2015)

Multicore fibers (MCFs) are expected as a good candidate for overcoming the capacity limit of a current optical communication system. This paper describes the recent progress on the MCFs for space-division multiplexing to be utilized in future large capacity long-distance transmission systems. Tradeoff issue between low crosstalk and high core density in MCFs is presented and prospect of large-space multiplicity of MCFs is discussed.
In-Flight Off-Surface Flow Visualization Using Infrared Imaging (1991)

<div class="htmlview paragraph">A flight test investigation was conducted to evaluate an infrared (IR) imaging technique to visualize off-surface flow phenomena. A single-engine, general-aviation airplane was equipped with an IR imaging system that viewed the region around the left wingtip. Vortical flow at the wingtip was seeded with sulfur hexafluoride, a gas with strong infrared absorbing and emitting characteristics. Different terrain and sky backgrounds were evaluated for their effect on IR images of vortical flow. The best IR images were obtained with a clear sky background. The results of the investigation indicate that IR flow visualization compliments existing smoke generator methods for off-surface flow visualization.</div>
New Synthetic Techniques for Advanced Propellant Ingredients: Trifluoromethanesulfonate Derivitive Intermediates (1987)

Abstract : The metathesis reaction between silver triflate and bromoalkanes potentially offers an attractive synthetic complement to the well known alcohol condensation with triflic anhydride for organic triflate esters. Dibromoalkanes can further give difunctional triflate intermediates and could provide convenient routes to asymmetrically substituted derivatives. Certain shorter members of the alpha,omega-dibromoalkane homologous series display a unique reactivity and product selectivity over higher homologues and corresponding 1 monobromoalknaes. Triflate products from monobromoalkanes and alpha,omega- dibromoalkanes greater than 1,4-dibromobutane can lead to benzene solvent alkylation or polymerization in CC14, but the lower 1,2- through 1,4- dibromoalkanes produce desired monobromoalkyl triflate and akanediyl ditriflate products under the same reaction conditions. Keywords: Trifluoromethanesulfonate; Energetic materials; Propellants; Ingredients; Synthesis(Chemistry); Fluorodintroethyl; Nitrogen compounds.
High-power microwave plasma pulse compression (1986)

It is shown that a plasma-loaded waveguide is sufficiently dispersive that very high-power microwave pulse compression is possible. The input microwave pulse can be either chirped or fixed frequency, if the waveguide plasma parameters are steady or variable in time, respectively. The initial calculations presented here are for a one-dimensional plasma.
Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure (2013)

Chronic cannabis exposure can lead to cerebellar dysfunction in humans, but the neurobiological mechanisms involved remain incompletely understood. Here, we found that in mice, subchronic administration of the psychoactive component of cannabis, delta9-tetrahydrocannabinol (THC), activated cerebellar microglia and increased the expression of neuroinflammatory markers, including IL-1β. This neuroinflammatory phenotype correlated with deficits in cerebellar conditioned learning and fine motor coordination. The neuroinflammatory phenotype was readily detectable in the cerebellum of mice with global loss of the CB1 cannabinoid receptor (CB1R, Cb1(-/-) mice) and in mice lacking CB1R in the cerebellar parallel fibers, suggesting that CB1R downregulation in the cerebellar molecular layer plays a key role in THC-induced cerebellar deficits. Expression of CB2 cannabinoid receptor (CB2R) and Il1b mRNA was increased under neuroinflammatory conditions in activated CD11b-positive microglial cells. Furthermore, administration of the immunosuppressant minocycline or an inhibitor of IL-1β receptor signaling prevented the deficits in cerebellar function in Cb1(-/-) and THC-withdrawn mice. Our results suggest that cerebellar microglial activation plays a crucial role in the cerebellar deficits induced by repeated cannabis exposure.
Optical beam position active sensing and control using acoustooptic satellite beams (2004)

This paper presents novel techniques and experimental results for precision active sensing and control of the position of a laser beam using dynamic acoustooptic diffraction patterns. Sensing of the acoustooptic (AO) diffraction pattern higher order beams is used to determine the position of the main optical beam (i.e., zero order beam) while minimally perturbing the main beam. In the experimental system a reduced Q acoustooptic modulator was used in the axial mode to generate symmetrically deviated +1 and -1 diffraction order satellite beams with a small fraction of the zero order power. Sensing the crossing time of scanned satellite beams past differential split bicell detectors to derive precise zero-crossing signals was used to precisely locate them and infer the main beam position. The symmetric configuration is particularly effective for accurately determining and calibrating the main beam position. A Bragg regime acoustooptic deflector was used to steer the position of the main beam over a range of angles, controlling it to a desired position, as well as stabilizing it by means of control of Bragg deflector RF frequency derived from the sensing signals. Experimentally, a 1 milli-radian angular divergence laser beam at 632.8 nm optical wavelength was controlled and settled to within (/spl plusmn/1/60) beam diameter in 1 sense/control feedback cycle of 80 msec. The cycle time was limited by the present control electronics; however, it could be much faster: fundamentally response time is limited by the acoustooptic beam transit time on the order of a microsecond. The general method of this paper could be applied at any optical wavelength where suitable acoustooptic modulators and photosensors can be obtained. The method can also be readily extended to operation in two axes, providing two-dimensional position sensing and control.
Fiber-based Doppler Lidar for Vector Velocity and Altitude Measurements (2015)

A coherent Doppler lidar which provides accurate velocity and altitude data was developed and demonstrated. The sensor is designed to address future NASA missions that require precision navigation and controlled soft landing on planetary bodies.
Spatial resolution enhancement in coaxial light scattering geometries (1977)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Alan C. Eckbreth and Jack W. Davis, "Spatial resolution enhancement in coaxial light scattering geometries," Appl. Opt. 16, 804-806 (1977) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase (1997)

Activation of the c-Abl protein tyrosine kinase by certain DNA-damaging agents contributes to downregulation of Cdk2 and G1 arrest by a p53-dependent mechanism. The present work investigates the potential role of c-Abl in apoptosis induced by DNA damage. Transient transfection studies with wild-type, but not kinase-inactive, c-Abl demonstrate induction of apoptosis. Cells that stably express inactive c-Abl exhibit resistance to ionizing radiation-induced loss of clonogenic survival and apoptosis. Cells null for c-abl are also impaired in the apoptotic response to ionizing radiation. We further show that cells deficient in p53 undergo apoptosis in response to expression of c-Abl and exhibit decreases in radiation-induced apoptosis when expressing inactive c-Abl. These findings suggest that c-Abl kinase regulates DNA damage-induced apoptosis.
Determination of <i>N</i>‐nitrosamines by automated dispersive liquid–liquid microextraction integrated with gas chromatography and mass spectrometry (2015)

An automated dispersive liquid-liquid microextraction integrated with gas chromatography and mass spectrometric procedure was developed for the determination of three N-nitrosamines (N-nitroso-di-n-propylamine, N-nitrosopiperidine, and N-nitroso di-n-butylamine) in water samples. Response surface methodology was employed to optimize relevant extraction parameters including extraction time, dispersive solvent volume, water sample pH, sodium chloride concentration, and agitation (stirring) speed. The optimal dispersive liquid-liquid microextraction conditions were 28 min of extraction time, 33 μL of methanol as dispersive solvent, 722 rotations per minute of agitation speed, 23% w/v sodium chloride concentration, and pH of 10.5. Under these conditions, good linearity for the analytes in the range from 0.1 to 100 μg/L with coefficients of determination (r(2) ) from 0.988 to 0.998 were obtained. The limits of detection based on a signal-to-noise ratio of 3 were between 5.7 and 124 ng/L with corresponding relative standard deviations from 3.4 to 5.9% (n = 4). The relative recoveries of N-nitroso-di-n-propylamine, N-nitrosopiperidine, and N-nitroso di-n-butylamine from spiked groundwater and tap water samples at concentrations of 2 μg/L of each analyte (mean ± standard deviation, n = 3) were (93.9 ± 8.7), (90.6 ± 10.7), and (103.7 ± 8.0)%, respectively. The method was applied to determine the N-nitrosamines in water samples of different complexities, such as tap water, and groundwater, before and after treatment, in a local water treatment plant.
Anthocyanin-Rich Extracts Inhibit Multiple Biomarkers of Colon Cancer in Rats (2006)

The aim of the present study was to investigate the chemoprotective activity of anthocyanin-rich extracts (AREs) from bilberry (Vaccinium myrtillus L.), chokeberry (Aronia meloncarpa E.), and grape (Vitis vinifera) by assessing multiple biomarkers of colon cancer in male rats treated with a colon carcinogen, azoxymethane. Fischer 344 male rats were fed the AIN-93 diet (control) or AIN-93 diet supplemented with AREs for 14 wk. Biomarkers that were evaluated included the number and multiplicity of colonic aberrant crypt foci (ACF), colonic cell proliferation, urinary levels of oxidative DNA damage, and expression of cyclooxygenase (COX) genes. To assess the bioavailability, levels of anthocyanins in serum, urine, and feces were evaluated. Total ACF were reduced (P<0.05) in bilberry, chokeberry, and grape diet groups compared with the control group. The number of large ACF was also reduced (P<0.05) in bilberry and chokeberry ARE-fed rats. Colonic cellular proliferation was decreased in rats fed bilberry ARE and chokeberry ARE diets. Rats fed bilberry and grape ARE diets had lower COX-2 mRNA expression of gene. High levels of fecal anthocyanins and increased fecal mass and fecal moisture occurred in ARE-fed rats. There was also a significant reduction (P<0.05) in fecal bile acids in ARE-fed rats. The levels of urinary 8-hydroxyguanosine were similar among rats fed different diets. These results support our previous in vitro studies suggesting a protective role of AREs in colon carcinogenesis and indicate multiple mechanisms of action.
Highly Efficient Secrecy-Preserving Proofs of Correctness of Computations and Applications (2007)

We present a highly efficient method for proving correctness of computations while preserving secrecy of the input values. This is done in an Evaluator-Prover model which can also be realized by a secure processor. We describe an application to secure auctions.
Elastomer-Modified Vinyl Esters as Structural Adhesives (1995)

Abstract Vinyl esters (epoxy-methacrylates) are preeminent chemical-and corrosion-resistant materials. Based primarily on addition-esterified cpoxy resins with methacrylic acid and diluted with styrene monomer, several products are available based on dicpoxide structure, molecular weight, modifier type (nitrile rubber, urethane. elycol, e.g.) and blends with styrenated polyester resins. A new dass of vinyl ester urethanes has also become commercially available. Elastomer modification of both types has shown that the fracture energy of epoxv vinyl esters can be enhanced to have a four-fold improvement Despite this, the elastomer-modified vinyl esters have not found use as a basis for free-radical curing structural adhesives. Addition of an epoxy-terminated rubber (ETBN) or a methacrylated-vinyl terminated rubber (VTBNX) to previously elastomermodified vinyl ester resin significantly improves overlap shear, T-peel, and bulk fracture propertics. This suggests potential application in structural adhesive development The cured specimen morphology of the combined rubber system provides clues for toughness enhancement
State of the Art in Computer Monitoring and Analysis of Grouting (2003)

Computer monitoring and analysis of grouting has come of age as a reliable and effective tool for better, faster, and less expensive grouting. This paper traces the development of computer monitoring and control systems, summarizes the benefits that can be realized from use of the systems, and presents the latest developments in specialized technology developed specifically for permeation grouting. Several case history applications of successful use of computer monitoring and analysis are presented. The Penn Forest Project, a new dam construction project in Pennsylvania, was a landmark project in the utilization of computer monitoring technology and is the only large project where full scale, side by side comparison of conventional monitoring techniques and computer monitoring systems is available This project provided clear, quantitative illustration of the many technical and cost benefits that result from computer monitoring. The Patoka Lake Seepage Remediation Project, located in southwestern Indiana, was another vital project in that it was the first grouting project requiring the use of computer monitoring undertaken by the U.S. Army Corps of Engineers (USACE), and in that it has helped set the standards for contracting methods and field application.
Synthesis Of Benzoxazole Monomers And Polymers (1994)

Di(hydroxyphenyl)benzoxazoles synthesized, then polymerized with aromatic dihalides. In comparison with previous routes to synthesis of polybenzoxazoles, this is simpler and more economical. New polybenzoxazoles may prove useful as adhesives, coatings, films, membranes, molding compounds, and composite matrices.
Streptococcal Fc receptors. II. Comparison of the reactivity of a receptor from a group C streptococcus with staphylococcal protein A. (1984)

The reactivity of a soluble Fc receptor from a group C streptococcus ( FcRc ) was compared antigenically and functionally with the staphylococcal Fc receptor, protein A. Protein A and FcRc were found to inhibit each others' binding to the Fc region of human IgG, indicating that they bind to sites that are in close proximity on the Fc region of human IgG. The two bacterial Fc receptors were antigenically unrelated. Differences were observed in the species and subclass reactivity of the two receptors. The patterns of binding of protein A and FcRc under various conditions suggested that these receptors reacted with distinct regions on the Fc region of immunoglobulins. FcRc bound more efficiently to goat, sheep, and cow IgG, protein A bound more efficiently to dog IgG, and neither receptor bound to rat IgG. Differences were also observed in the reactivity towards human IgG subclasses. The FcRc bound to all samples of the four human IgG subclass standards. Protein A bound to IgG1, IgG2, and IgG4, and to one of two IgG3 myeloma proteins tested. The reactivity of our soluble FcRc corresponds to a type III streptococcal Fc receptor classified by the reactivity of intact bacteria.
Molecular Characterization, Compositional Analysis, and Germination Evaluation of a High‐Oleic Soybean Generated by the Suppression of <i>FAD2‐1</i> Expression (2014)

ABSTRACT Soybean [ Glycine max (L.) Merr.] oil is one of the most consumed and highest produced vegetable oils. However, the high percentage of polyunsaturated fatty acids in soybean oil limits its stability and shelf life. Here we report the generation and characterization of a high oleic acid soybean event (305423 soybean) that has an elevated content of monounsaturated oleic acid and reduced presence of polyunsaturated linoleic acid and linolenic acid. This transgenic event was generated by the insertion of a soybean ω‐6 desaturase ( FAD2 ) gene fragment ( gm‐fad2‐1 ), resulting in the suppression of endogenous FAD2‐1 expression, and a modified version of the soybean acetolactate synthase ( ALS ) gene ( gm‐hra ), used as a selectable marker. Molecular characterization revealed that 305423 soybean harbors four DNA inserts containing multiple copies of complete and partial gm‐fad2‐1 gene cassettes and a single copy of the intact gm‐hra gene cassette. However, these DNA inserts seemed to be inherited together without segregation. The suppression of endogenous FAD2‐1 led to an increase of oleic acid (18:1) from 211 to 765 g kg –1 along with concurrent reduction of both linoleic acid (18:2) from 525 to 36.2 g kg –1 and linolenic acid (18:3) from 93.5 to 53.9 g kg –1 out of total fatty acyl groups. The 305423 soybean was also subjected to nutrient composition analyses and phenotypic and agronomic performance evaluations and found to be comparable to the control soybean except for the expected traits.
Heterocycle‐Fused Cyclohexylglycine Derivatives as Novel Dipeptidyl Peptidase‐IV Inhibitors. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Congestion Exposure in Mobile Wireless Communications (2010)

This paper presents an approach to apply congestion exposure concepts to mobile wireless communication, with a particular focus on LTE's E-UTRAN. Assuming Re-ECN as the congestion exposure mechanism, we show how the different functional Re-ECN components can be mapped to logical elements in the E-UTRAN architecture. Moreover we present a novel concept of Wireless ECN, which allows for generating congestion (cost) indication taking wireless resource consumption into account. We show how such a mechanism can be used to enhance throughput and reduce buffering delays in wireless networks with heterogeneous Modulation and Coding Scheme configurations for different users.
DAcc: Decentralized Ledger based Access Control for Enterprise Applications (2019)

Access control is one of the fundamental security mechanisms of IT systems. Most existing access control schemes rely on a centralized party to manage and enforce access control policies. As decentralized ledger technologies, especially permissioned networks, find more applicability beyond cryptocurrencies in enterprise solutions is expected that the security requirements will increase. Therefore, it is necessary to develop an access control system that works in a decentralized environment without compromising the unique features of a decentralized ledger. Decentralized ledger based access control schemes have been proposed but have limitations such as lack of capability to protect the access history and detect/tolerate malicious participants. In order to address these concerns, we propose a novel decentralized ledger based access control system that utilizes cryptography. The newly proposed system is flexible and works with various storage system. The proposed system also provides verifiability for end users to detect compromised nodes in the decentralized ledger and high level privacy. We implement the scheme using Hyperledger Fabric and give detailed information of the prototype, and also assess its performance to show that it is practical for real world applications.
Streptococcal Antitumor Protein: Expression in<i>Escherichia coli</i>Cells and Properties of the Recombinant Protein (1991)

Streptococcal antitumor protein (SAGP) was produced by transformed E. coli JM103 carrying the SAGP gene downstream from the tac promoter. The purified recombinant SAGP had the same N-terminal amino acid sequence as that of the native SAGP isolated from Streptococcus pyogenes Su cells. Gel filtration analysis showed that the recombinant SAGP was a dimer, while the native SAGP was a tetramer. When the antitumor activity was tested against sarcoma 180 cells, the IC50 of the recombinant SAGP was 0.3 μg/ml, about a quarter as active as the native SAGP. These results suggest that the quaternary structure of SAGP is important for the antitumor activity.
Retiming gated-clocks and precharged circuit structures (1993)

This paper presents methods for retiming VLSI systems that contain precharged circuit structures and/or clock signals. Due to the tangible speed, power, and area benefits of circuit structures that utilize precharging techniques and/or gated clock signals, both are common in high-performance VLSI designs. Previous methods for performing retiming (i.e., optimizing the placement of latches) have not, however, addressed the pecularities of such circuit structures, and consequently, have not been applicable to many non-ASIC VLSI systems. The presented methods immediately lead to an algorithm which runs, to within a constant factor, in the same amount of time as previous retiming algorithms, yet is capable of handling precharged structures and gated clock signals. Using the algorithm, it is possible to apply retiming techniques to full custom VLSI designs. Though the paper focuses on the problem of retiming, the methods described are also applicable to the problem of verification. All results are based upon a general set of timing constraints which is directly applicable to circuits that contain precharged structures and gated clocks.
Thermal Management Using Synthetic Jet Ejectors (2004)

The utility of a synthetic jet ejector for thermal management at low flow rates is discussed. A synthetic jet ejector typically consists of a primary "zero-mass-flux" unsteady jet driving a secondary airflow through a low profile, high aspect ratio channel. A simple configuration of a nominally two-dimensional jet ejector in a rectangular channel is used to investigate the effects of channel width on the induced flow rate, power dissipated, heat transfer coefficient and thermal efficiency. An active heat sink for high power microprocessors is developed using the jet ejector concept and its performance is discussed.
Silver-clad nitride semiconductor laser diode (2009)

An edge-emitting laser diode is described in which the epitaxial upper cladding layer is replaced with a metal contact selected for its optical as well as electrical properties. The structure is demonstrated with an In0.1Ga0.9N multiple-quantum-well laser diode operating at 412 nm with silver rather than the typical p-type AlGaN for the upper cladding. Silver is effective as a cladding layer because of its very low index of refraction at the lasing wavelength, so that the guided optical mode exhibits minimal penetration into the silver. Eliminating the epitaxial upper cladding layer reduces thermal degradation of the InGaN multiple-quantum-well active layer.
A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents (2012)

PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency in vitro and efficacy in vivo for preventing neuroapoptosis. The novel chemotype could provide pharmacological probes and potential therapeutic agents for glutamatergic hypofunction and its related neurological and psychiatric disorders.