gebhart/patrepeval huggingface dataset:
Cluster-based Multihop Synchronization Scheme for Femtocell Network (2012)

ABSTRACT: FemtocellÂ technology has been drawing considerable attentionÂ as a cost-effective means of improving cellular coverage andÂ capacity. It is connected to the core network through an IP backhaul and can only use timing protocols such as IEEE1588 or Network Time Protocol (NTP). Furthermore, the femtocell is installed indoor, and cannot use a GPS antenna for time synchronization.Â High-precision crystal oscillators can solve the timing problem, but they are often too expensive for consumer grade devices. Therefore, femtocell Base Station (fBS) synchronization is one of the principle technical trends in femtocell deployment. Since fBSand macrocell Base Station (mBS) network operates on the same frequency under a licensed spectrum, fBS network can interfere with the macrocell network. In addition, fBSs can also interfere with each other if multiple units are in close proximity. Furthermore, in a flat fBS structured network using IEEE 1588 synchronization algorithm and fBS-fBS synchronization scheme creates offset and frequency error which results inaccurate synchronization. In order to reduce offset and frequency error (skew), this paper proposed a cluster-based multihop synchronization scheme to achieve precise in fBS neighbor nodes. The proposed scheme is able to reduce the offset and skew significantly.ABSTRAK: Teknologi Femtocell telah menjadi tumpuan sebagai alat yang kos-efektif dalam memperbaiki liputan mudahalih dan kapasiti. Ia menghubungkan jaringan teras melalui IP backhaul dan hanya boleh menggunakan protokol masa seperti IEEE1588 atau Protokol Jaringan Masa (NTP). Seterusnya, femtocell dipasang di dalam, dan tidak boleh menggunakan antena GPS untuk sinkronisasi masa. Osilator Kristal yang tinggi kejituannya boleh menyelesaikan masalah masa, tetapi ianya mahal bagi gred peranti consumer. Oleh itu, sinkronisasi Stesen Asas femtocell (fBS) adalah salah satu tren teknikal prinsip dalam deployment femtocell. Memandangkan fBS dan jaringan Stesen Asas makrosel (mBS) beroperasi pada frekuensi yang sama di bawah spektrum lesen jaringan fBS boleh mengganggu jaringan makrosel. Tambahan pula, fBS juga boleh mengganggu antara satu sama lain jika unit pelbagai adalah close proximity. Tambahan lagi, bagi struktur jaringan rata fBS menggunakan algorisma sinkronisasi IEEE 1588 dan skema sinkronisasi fBS-fBS mencipta offset dan ralat frekuensi yang menyebabkan ketidaktepatansinkronisasi. Bagi mengurangkan offset dan ralat frekuensi (skew), kajian ini mencadangkan multihop berasaskan kluster skema sinkronisasi bagi mencapai kejituan dalam mod kejiranan fBS. Skema yang dicadangkan boleh mengurangkan offset dan skew dengan berkesan.KEYWORDS:Â femtocell base satationt (FBS); synchronization; frequency division multiple access (OFDMA); inter-cluster, intra-cluster
In silico genome‐scale reconstruction and validation of the <i>Staphylococcus aureus</i> metabolic network (2005)

A genome-scale metabolic model of the Gram-positive, facultative anaerobic opportunistic pathogen Staphylococcus aureus N315 was constructed based on current genomic data, literature, and physiological information. The model comprises 774 metabolic processes representing approximately 23% of all protein-coding regions. The model was extensively validated against experimental observations and it correctly predicted main physiological properties of the wild-type strain, such as aerobic and anaerobic respiration and fermentation. Due to the frequent involvement of S. aureus in hospital-acquired bacterial infections combined with its increasing antibiotic resistance, we also investigated the clinically relevant phenotype of small colony variants and found that the model predictions agreed with recent findings of proteome analyses. This indicates that the model is useful in assisting future experiments to elucidate the interrelationship of bacterial metabolism and resistance. To help directing future studies for novel chemotherapeutic targets, we conducted a large-scale in silico gene deletion study that identified 158 essential intracellular reactions. A more detailed analysis showed that the biosynthesis of glycans and lipids is rather rigid with respect to circumventing gene deletions, which should make these areas particularly interesting for antibiotic development. The combination of this stoichiometric model with transcriptomic and proteomic data should allow a new quality in the analysis of clinically relevant organisms and a more rationalized system-level search for novel drug targets.
Wideband TDOA/FDOA processing using summation of short-time CAF's (1999)

A commonly used method of calculating TDOA and FDOA is the cross ambiguity function (CAF). The narrowband model assumes that the Doppler is constant over the bandwidth of the signal. When time companding, caused by relative motion, becomes large enough, the CAF performance is degraded. One method of compensation is to resample the signal, but this can be computationally intensive, especially if there is a wide range of time companding. A second method is to reduce the time the CAF is computed over, but the processing gain is reduced. If the short-term CAFs are recombined after the time companding has been compensated, much of the processing gain can be recovered. In this paper, three novel methods of recombining short-time CAFs are developed and analyzed. The first method is to estimate the TDOA and FDOA for each short-time CAF. The second method is to compensate and noncoherently add the CAFs together. This improves the peak detection over the first method but not the TDOA and FDOA accuracy. The third method is to compensate for both time and phase and then coherently add the short-time CAFs together. This last method improves the FDOA accuracy over the first two methods. The effects of sampled data and frequency dual are analyzed. Simulation results are provided to verify analytical results.
Flood Management in California (2012)

California’s development and success have been shaped by its ability to manage floods. This management has varied over the history of California’s economic and political development and continues in various forms today. California will always have flood problems. A range of options are available to aid in flood management problems and have been used over time. These options can be contrasted with flood management elsewhere and the types of options used to manage other types of hazards in California, such as earthquakes, wildfires, and droughts. In the future, flood management in California will require greater reliance on local funding and leadership, reflecting diminished federal and state funding, with more effective state and federal guidance. Effective flood management will also tend to integrate flood management with actions to achieve environmental and other water supply objectives, both to gain revenues from a broader range of beneficiaries as well as to make more efficient use of land and water in a state where both are often scarce.
Design of consumption management system based on RFID (2014)

Welcome to the WIT Press eLibrary - the home of the Transactions of the Wessex Institute collection, providing on-line access to papers presented at the Institute's prestigious international conferences and from its State-of-the-Art in Science & Engineering publications.
Detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling (2005)

Although the micro-organisms forming the cutaneous microbiota are considered to play important roles in the modification and prevention of skin diseases, a comprehensive analysis of their composition has not yet been carried out because of difficulties in determining yet-to-be-cultured micro-organisms in the samples. Swab-scrubbed forehead skin samples of five healthy volunteers were analysed by profiling 16S rRNA genes, as well as by conventional culture methods, to provide a profile of the cutaneous microbiota that included yet-to-be-cultured bacteria from normal human skin. Cluster analyses of the 16S rRNA gene sequences indicated a marked increase in diversity compared with that derived from the culture methods. Nineteen previously recognized species and 13 novel phylotypes were obtained from the analysis of 416 clones. In addition to well-known bacteria such as Staphylococcus epidermidis and Propionibacterium acnes, phylotype A, the 16S rRNA gene of which is 97 % similar to that of Methylophilus methylotrophus, was detected in three of the five samples, in one of which it was the predominant clone. Culture-independent genetic profiling of 16S rRNA genes for detecting human cutaneous microbiota has allowed us to detect potentially novel components of the cutaneous microbiota in humans.
Development of Coatings for Environments with High Sulfur And/or Carbon Activities at Low Oxygen Potentials (2002)

Abstract High velocity oxy-fuel (HVOF) thermal spray coatings of TiAl and several Al- as well as Al-Ti-cementation coatings were applied on ferritic and austenitic stainless steels and tested in a reducing sulfidizing atmosphere, under metal dusting conditions and in a sulfidizing carburizing atmosphere at a temperature of 700°C. The tests were run isothermally for up to 1000 h. The thermal spray coatings and the Al-diffusion coatings were corrosion resistant in purely sulfidizing and in metal dusting atmospheres. If a sulfidizing and carburizing environment is present only the Al-Ti-codiffusion coating can provide protection over the whole test duration.
Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex (2003)

Movement through the endocytic pathway occurs principally via a series of membrane fusion and fission reactions that allow sorting of molecules to be recycled from those to be degraded. Endosome fusion is dependent on SNARE proteins, although the nature of the proteins involved and their regulation has not been fully elucidated. We found that the endosome-associated hepatocyte responsive serum phosphoprotein (Hrs) inhibited the homotypic fusion of early endosomes. A region of Hrs predicted to form a coiled coil required for binding the Q-SNARE, SNAP-25, mimicked the inhibition of endosome fusion produced by full-length Hrs, and was sufficient for endosome binding. SNAP-25, syntaxin 13, and VAMP2 were bound from rat brain membranes to the Hrs coiled-coil domain. Syntaxin 13 inhibited early endosomal fusion and botulinum toxin/E inhibition of early endosomal fusion was reversed by addition of SNAP-25(150-206), confirming a role for syntaxin 13, and establishing a role for SNAP-25 in endosomal fusion. Hrs inhibited formation of the syntaxin 13-SNAP-25-VAMP2 complex by displacing VAMP2 from the complex. These data suggest that SNAP-25 is a receptor for Hrs on early endosomal membranes and that the binding of Hrs to SNAP-25 on endosomal membranes inhibits formation of a SNARE complex required for homotypic endosome fusion.
Treatment of Helicobacter pylori (1999)

Over the 14 years since Helicobacter pylori came to the attention of the medical community, we have reached the position that the organism is generally believed to be a serious pathogen. It causes a chronic infection with complications that include gastric and duodenal ulcer, gastric mucosaassociated lymphoid tissue lymphoma and gastric cancer. It is therefore an important cause of morbidity and mortality. We still do not have a perfect treatment for the infection, but enormous strides have been made since its discovery and acceptable treatments are now available. The best of these are the acid pump inhibitor- and ranitidine bismuth citrate-based triple therapies that provide 85–95% eradication in most studies. Better treatments and vaccination programmes may become available now that the Helicobacter genome has been decoded, raising the possibility of ‘designer’ antibiotics and vaccines. In the meantime, the current key questions are: How can our current therapies be improved? Who should be treated? What, if any, are the potential risks of widespread H. pylori eradication? And how is the organism transmitted? Without doubt, many of these questions will be addressed in the succeeding years. The papers presented in these proceedings represent an up-to-date analysis (much of it based on new data) by recognized experts. The views expressed are often provocative, but are backed by scientific data.
GAD67-GFP knock-in mice have normal sleep–wake patterns and sleep homeostasis (2010)

Gamma-aminobutyric acid (GABA) ergic neurons are important for controlling sleep and wakefulness but are difficult to identify, limiting their study. Knock-in mice with GABAergic neurons labeled by expression of green fluorescent protein (GFP) under control of the glutamate decarboxylase 67 (GAD67) promoter are now extensively used in neuroscience. However, it is unknown whether these mice have a normal sleep phenotype. Compared with wild-type control mice, GAD67-GFP knock-in mice had the same amount of non-rapid eye movement (NREM) sleep and rapid-eye movement (REM) sleep, a similar diurnal distribution of sleep, no NREM or REM sleep differences in electroencephalogram power, and normal sleep rebound following 6-h sleep deprivation. Our results suggest GAD67-GFP knock-in mice are an excellent tool for study of GABAergic neurons involved in sleep-wake regulation.
Room‐temperature plastic inorganic semiconductors for flexible and deformable electronics (2020)

Abstract Flexible electronics ushers in a revolution to the electronics industry in the 21st century. Ideally, all components of a flexible electronic device including the functional component shall comply with the deformation to ensure the structural and functional integrity, imposing a pressing need for developing room‐temperature strain‐tolerant semiconductors. To this end, there is a long‐standing material dilemma: inorganic semiconductors are typically brittle at room temperature except for size‐induced flexibility; by contrast, organic semiconductors are intrinsically soft and flexible but the electrical performance is poor. This is why the discovery of bulk plasticity in Ag 2 S at room temperature and ZnS in darkness is groundbreaking in solving this long‐standing material dilemma between the mechanical deformability and the electrical performance. The present review summarizes the background knowledge and latest advances in the emerging field of plastic inorganic semiconductors. At the outset, we argue that the plasticity of inorganic semiconductors is vital to strain tolerance of electronic devices, which has not been adequately emphasized. The mechanisms of plasticity are illustrated from the perspective of chemical bonding and dislocations. Plastic inorganic materials, for example, ionic crystals (insulators), ZnS in darkness, and Ag 2 S, are discussed in detail in terms of their prominent mechanical properties and potential applications. We conclude the article with several key scientific and technological questions to address in the future study.
Using one-class and two-class SVMs for multiclass image annotation (2005)

We propose using one-class, two-class, and multiclass SVMs to annotate images for supporting keyword retrieval of images. Providing automatic annotation requires an accurate mapping of images' low-level perceptual features (e.g., color and texture) to some high-level semantic labels (e.g., landscape, architecture, and animals). Much work has been performed in this area; however, there is a lack of ability to assess the quality of annotation. In this paper, we propose a confidence-based dynamic ensemble (CDE), which employs a three-level classification scheme. At the base-level, CDE uses one-class support vector machines (SVMs) to characterize a confidence factor for ascertaining the correctness of an annotation (or a class prediction) made by a binary SVM classifier. The confidence factor is then propagated to the multiclass classifiers at subsequent levels. CDE uses the confidence factor to make dynamic adjustments to its member classifiers so as to improve class-prediction accuracy, to accommodate new semantics, and to assist in the discovery of useful low-level features. Our empirical studies on a large real-world data set demonstrate CDE to be very effective.
Time-dependent crack growth in brittle rocks and field applications to geologic hazards (2007)

The primary focus of this research is to evaluate the time-dependent crack growth in rocks using lab tests and numerical modeling and its application to geologic hazard problems. This research utilized Coconino sandstone and Columbia granite as the study materials and produced the subcritical crack growth parameters in both mode I and II loadings using the rock materials. The mode I loading test employs three different types of fracture mechanics tests: the Double Torsion (DT), the Wedge Splitting (WS), and the Double Cantilever Beam (DCB) test. Each test measured the mode I crack velocity. The DT test indirectly measured the crack velocity using the load relaxation method. The WS and DCB tests directly measured the crack velocity by monitoring using a video recording. The different mode I subcritical crack growth parameters obtained from the three tests are discussed. For the mode II loading test, this study developed a new shear fracture toughness test called the modified Punch-Through Shear (MPTS). The MPTS test conducted at different loading rates produced the mode II subcritical crack growth parameters. These fracture mechanics tests were calibrated and simulated using the distinct element method (DEM) and the finite element method (FEM). DEM analysis employed the particle flow code (PFC) to simulate the mixed mode crack growth and to match with the failure strength envelop of the triaxial compressive tests. FEM analysis employed the Phase2 program to analyze the crack tip stress distribution and the FRANC2D program to calculate the modes I and II stress intensity factors. The fracture mechanics tests and numerical modeling showed well the dependency of the mode II subcritical crack growth parameters according to confining pressure, loading rate, and the mode II fracture toughness. Finally, the UDEC modeling based on DEM is utilized in this study to forecast the long-term stability of the Coconino rock slope, as one of geologic hazards. The fracture mechanics approach is implemented in the program using the modes I and II subcritical crack growth parameters obtained from the lab tests and numerical modeling. Considering the progressive failure of rock bridges due to subcritical crack growth, the UDEC results predicted the stable condition of the Coconino rock cliff over 10,000 years. This result was validated by comparing it with the previous planar failure case.
Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates. (2017)

In patients treated with oral and intravenous bisphosphonates without chemotherapy-associated osteonecrosis of the jaw, antibiotic prophylaxis prior to oral surgery is an important tool to avoid osteonecrosis and promote healing of the affected area. If the patient previously exhibited chemotherapy-associated osteonecrosis after tooth extraction, antibiotic prophylaxis is indicated to prevent recurrent osteonecrosis and promote healing of the extraction site. If chemotherapy-associated osteonecrosis is already present, antibiotic therapy is a vital part of conservative management to reduce the symptomatology of MRONJ and keep it from worsening. Finally, a lack of clinical data and randomized controlled trials makes it difficult to choose the most appropriate protocol for the various clinical situations studied. <b>Key words:</b>Bisphosphonates, antibiotic prophylaxis, maxillary osteonecrosis, antibiotic treatment.
Removal of Tattoos by CO<sub>2</sub> Laser (1980)

The physics, technique of use, and results obtained in removal of tattoos by a CO 2 laser are discussed and described.
Reduced Differentiation Potential of Primary <i>MyoD</i>−/− Myogenic Cells Derived from Adult Skeletal Muscle (1999)

To gain insight into the regeneration deficit of MyoD-/- muscle, we investigated the growth and differentiation of cultured MyoD-/- myogenic cells. Primary MyoD-/- myogenic cells exhibited a stellate morphology distinct from the compact morphology of wild-type myoblasts, and expressed c-met, a receptor tyrosine kinase expressed in satellite cells. However, MyoD-/- myogenic cells did not express desmin, an intermediate filament protein typically expressed in cultured myoblasts in vitro and myogenic precursor cells in vivo. Northern analysis indicated that proliferating MyoD-/- myogenic cells expressed fourfold higher levels of Myf-5 and sixfold higher levels of PEA3, an ETS-domain transcription factor expressed in newly activated satellite cells. Under conditions that normally induce differentiation, MyoD-/- cells continued to proliferate and with delayed kinetics yielded reduced numbers of predominantly mononuclear myocytes. Northern analysis revealed delayed induction of myogenin, MRF4, and other differentiation-specific markers although p21 was upregulated normally. Expression of M-cadherin mRNA was severely decreased whereas expression of IGF-1 was markedly increased in MyoD-/- myogenic cells. Mixing of lacZ-labeled MyoD-/- cells and wild-type myoblasts revealed a strict autonomy in differentiation potential. Transfection of a MyoD-expression cassette restored cytomorphology and rescued the differentiation deficit. We interpret these data to suggest that MyoD-/- myogenic cells represent an intermediate stage between a quiescent satellite cell and a myogenic precursor cell.
Netrin-1 Expression Is an Independent Prognostic Factor for Poor Patient Survival in Brain Metastases (2014)

The multifunctional molecule netrin-1 is upregulated in various malignancies and has recently been presented as a major general player in tumorigenesis leading to tumor progression and maintenance in various animal models. However, there is still a lack of clinico-epidemiological data related to netrin-1 expression. Therefore, the aim of our study was to elucidate the association of netrin-1 expression and patient survival in brain metastases since those constitute one of the most limiting factors for patient prognosis. We investigated 104 brain metastases cases for netrin-1 expression using in-situ hybridization and immunohistochemistry with regard to clinical parameters such as patient survival and MRI data. Our data show that netrin-1 is strongly upregulated in most cancer subtypes. Univariate analyses revealed netrin-1 expression as a significant factor associated with poor patient survival in the total cohort of brain metastasis patients and in sub-entities such as non-small cell lung carcinomas. Interestingly, many cancer samples showed a strong nuclear netrin-1 signal which was recently linked to a truncated netrin-1 variant that enhances tumor growth. Nuclear netrin-1 expression was associated with poor patient survival in univariate as well as in multivariate analyses. Our data indicate both total and nuclear netrin-1 expression as prognostic factors in brain metastases patients in contrast to other prognostic markers in oncology such as patient age, number of brain metastases or Ki67 proliferation index. Therefore, nuclear netrin-1 expression constitutes one of the first reported molecular biomarkers for patient survival in brain metastases. Furthermore, netrin-1 may constitute a promising target for future anti-cancer treatment approaches in brain metastases.