gebhart/patrepeval huggingface dataset:
Modeling shear behavior of reinforced concrete beams strengthened with externally bonded CFRP sheets (2017)

Extensive research work has been performed on shear strengthening of reinforced concrete (RC) beams retrofitted with externally bonded carbon fiber reinforced polymer (CFRP) in form of strips. However, most of this research work is experimental and very scarce studies are available on numerical modelling of such beams due to truly challenging nature of modelling concrete shear cracking and interfacial interaction between components of such beams. This paper presents an appropriate model for RC beam and to simulate its cracking without numerical computational difficulties, convergence and solution degradation problems. Modelling of steel and CFRP and their interfacial interaction with concrete are discussed. Finally, commercially available non-linear finite element software ABAQUS is used to validate the developed finite element model with key tests performed on full scale T-beams with and without CFRP retrofitting, taken from previous extensive research work. The modelling parameters for bonding behavior of CFRP with special anchors are also proposed. The results presented in this research work illustrate that appropriate modelling of bond behavior of all the three types of interfaces is important in order to correctly simulate the shear behavior of RC beams strengthened with CFRP.
Big Data Processing for Prediction of Traffic Time Based on Vertical Data Arrangement (2014)

To predict future traffic conditions in each road with unique spatiotemporal pattern, it is necessary to analyze the conditions based on historical traffic data and select time series forecasting methods which can be predicting next pattern for each road according to the analyzed results. Our goal is to create a new statistical model and a new system for predictive graphs of traffic times based on big data processing tools. First, we suggest a vertical data arrangement, gathering past traffic times in the same time slot for long-term prediction. Second, we analyze each traffic pattern to select time-series variables because a time-series forecasting method for a location and a time will be selected according to the variables that are available. Third, we suggest a spatiotemporal prediction map, which is a two-dimensional map with time and location. Each element in the map represents a time-series forecasting method and an R-squared value as indicator of prediction accuracy. Finally, we introduce a new system including RHive as a middle point between R and Hadoop clusters for generating predicted data efficiently from big historical data.
By the Laying on of Hands and by Prayer: An Analysis of Power in the Rite of Ordination (1994)

Medieval pilgrims walked the labyrinth in the cathedral at Chartres in place of a journey to the Holy Land.It was safer than pilgrimage; it was also more certain.All paths led to the center.Theseus would have wandered for days in the maze on Crete, stumbling only onto paths that ended in empty corners;
DecentID: Decentralized and Privacy-Preserving Identity Storage System Using Smart Contracts (2018)

Many Internet services require the registration of an account before permitting use of their services. Over time, many Internet users end up with a multitude of accounts with separated identities. A solution to this problem is offered by single-sign-on (SSO) providers, where a user can create a single identity and use this identity for multiple services. However it requires the user to trust the SSO provider. When the provider blocks access to the identities the users lose access to their subscribed services. To avoid this problem, we propose DecentID, a completely decentralized identity storage system that does not require a centralized trusted third party. Instead, a public blockchain is used as trust anchor. Identities can be created and used for different services. Each service can only read the identity attributes disclosed for it without being able to read attributes the user wants to keep secret.
Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter. (1990)

A genomic clone for human carboxypeptidase has been isolated with a probe for rat CPA1 cDNA. A 1.7-kb HindIII/EcoRI fragment from the 3' flanking region of human carboxypeptidase detects a DNA polymorphism with BglIII. Multipoint linkage analysis with an established map of chromosome 7 markers shows that the most likely location of carboxypeptidase is at 7q31-qter, between D7S87 and D7S93. All other placements can be excluded with odds greater than 100:1. These and other markers confirm that carboxypeptidase lies distal to the locus for cystic fibrosis, at a distance of approximately 12 centimorgans. The regions containing identity to the rat gene were sequenced and shown to be 82% identical to exons 9 and 10 of the rat gene. The presence of a codon for isoleucine at the residues corresponding to codon 255 of rat CPA1 cDNA strongly suggests that the A form of human carboxypeptidase has been isolated.
Immortal mouse dendritic cell lines : new models to investigate the immunobiology of dendritic cells (1995)

Dendritic cells (DC), including epidermal Langerhans cells play a primary role in the initiation of T cell-mediated immune responses. A number of studies has detailed the surface immunophenotype and has demonstrated the potent antigen presenting function of DC obtained from different tissues. However, the molecular basis of the unique immunostimulatory properties of DC, the biochemical pathways of signal transduction and the fine mechanisms of antigen processing remain to be identified. This lack of knowledge is mostly due to the small numbers of DC that can be obtained from any tissue and the difficulties in DC purification. Recently, long-term DC lines have been established from mouse spleen and skin. We have generated immortal DC lines from mouse tissues using a novel retroviral vector carrying a myc-env fusion gene. These DC lines display most of the morphologic, immunophenotypic and functional attributes of DC including the ability to initiate T cell responses in vivo, and could prove to be a very useful model for investigating the immunobiology of mouse DC
Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5 (2012)

Carba-NAD is a synthetic compound identical to NAD except for one substitution, where an oxygen atom adjacent to the anomeric linkage bearing nicotinamide is replaced with a methylene group. Because it is inert in nicotinamide displacement reactions, carba-NAD is an unreactive substrate analogue for NAD-consuming enzymes. SIRT3 and SIRT5 are NAD-consuming enzymes that are potential therapeutic targets for the treatment of metabolic diseases and cancers. We report an improved carba-NAD synthesis, including a pyrophosphate coupling method that proceeds in approximately 60% yield. We also disclose the X-ray crystal structures of the ternary complexes of SIRT3 and SIRT5 bound to a peptide substrate and carba-NAD. These X-ray crystal structures provide critical snapshots of the mechanism by which human sirtuins function as protein deacylation catalysts.
Towards viable certificate-based authentication for the internet of things (2013)

The vision of the Internet of Things considers smart objects in the physical world as first-class citizens of the digital world. Especially IP technology and RESTful web services on smart objects promise simple interactions with Internet services in the Web of Things, e.g., for building automation or in e-health scenarios. Peer authentication and secure data transmission are vital aspects in many of these scenarios to prevent leakage of personal information and harmful actuating tasks. While standard security solutions exist for traditional IP networks, the constraints of smart objects demand for more lightweight security mechanisms. Thus, the use of certificates for peer authentication is predominantly considered impracticable. In this paper, we investigate if this assumption is valid. To this end, we present preliminary overhead estimates for the certificate-based DTLS handshake and argue that certificates - with improvements to the handshake - are a viable method of authentication in many network scenarios. We propose three design ideas to reduce the overheads of the DTLS handshake. These ideas are based on (i) pre-validation, (ii) session resumption, and (iii) handshake delegation. We qualitatively analyze the expected overhead reductions and discuss their applicability.
Exploratory study on photoinduced single electron transfer reactions of .alpha.,.beta.-epoxy ketones with amines (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExploratory study on photoinduced single electron transfer reactions of .alpha.,.beta.-epoxy ketones with aminesEietsu Hasegawa, Kenyuki Ishiyama, Takaaki Horaguchi, and Takahachi ShimizuCite this: J. Org. Chem. 1991, 56, 4, 1631–1635Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/jo00004a052https://doi.org/10.1021/jo00004a052research-articleACS PublicationsRequest reuse permissionsArticle Views2033Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High thermal stability of cross-linked aromatic self-assembled monolayers: Nanopatterning via selective thermal desorption (2007)

An extremely high thermal stability of electron cross-linked biphenyl self-assembled monolayers (SAMs) is reported. The authors found that pristine biphenylthiol SAMs desorb at ∼400K from gold surfaces, which is induced by a breaking of C–S bonds. Despite of a similar bond cleavage in cross-linked SAMs, these remain on the surface up to 1000K, which is the highest temperature reported for a SAM. When patterns of pristine and cross-linked SAMs are heated, the pristine regions desorb, and the cross-linked regions remain on the surface. The authors show that this thermal desorption lithography can be utilized for the fabrication of molecular surface nanostructures.
Proteome-wide Profiling of Isoniazid Targets in <i>Mycobacterium tuberculosis</i> (2006)

Isoniazid (INH) is an essential drug used to treat tuberculosis. The mycobactericidal agents are INH adducts [INH-NAD(P)] of the pyridine nucleotide coenzymes, which are generated in vivo after INH activation and which bind to, and inhibit, essential enzymes. The NADH-dependent enoyl-ACP reductase (InhA) and the NADPH-dependent dihydrofolate reductase (DfrA) have both been shown to be inhibited by INH-NAD(P) adducts with nanomolar affinity. In this paper, we profiled the Mycobacterium tuberculosis proteome using both the INH-NAD and INH-NADP adducts coupled to solid supports and identified, in addition to InhA and DfrA, 16 other proteins that bind these adducts with high affinity. The majority of these are predicted to be pyridine nucleotide-dependent dehydrogenases/reductases. They are involved in many cellular processes, including S-adenosylmethionine-dependent methyl transfer reactions, pyrimidine and valine catabolism, the arginine degradative pathway, proton and potassium transport, stress response, lipid metabolism, and riboflavin biosynthesis. The targeting of multiple enzymes could, thus, account for the pleiotropic effects of, and powerful mycobactericidal properties of, INH.
Merocyanine 540-sensitized photoinactivation of enveloped viruses in blood products: site and mechanism of phototoxicity (1992)

The amphipathic dye, merocyanine 540 (MC540), which preferentially photosensitizes enveloped viruses and virus-infected cells, is currently being evaluated in preclinical models as a blood sterilizing agent. In this communication, we report on an initial analysis of the site and nature of MC540-mediated photodynamic damages to human herpes simplex virus type 1 and human cytomegalovirus. The comigration of dye molecules and virions on a gel filtration column, the red-shift of the fluorescence emission spectrum of virus-containing fractions, and the distribution of MC540-treated virions in an aqueous two-phase partition system were indicative of MC540 binding to the enveloped viruses and localizing in a lipophilic environment (most likely the viral envelope). Fluorescence quenching and fluorescence resonance energy transfer experiments suggested that both dye monomers and dimers were capable of partitioning into the lipid bilayer of the viral envelope. Adsorption and penetration assays and immunohistochemical analyses of viral antigen expression showed that MC540-sensitized irradiation interfered with early phases of the infectious process, the adhesion to the host cell, the penetration of the host cell, and the translocation of the virus into the nucleus of the host cell. The inactivation of viruses was inhibited if oxygen in the medium was displaced by argon, enhanced if air was displaced by pure oxygen or if water was replaced by deuterium oxide. This suggested that the MC540-sensitized photoinactivation of enveloped viruses is an oxygen-dependent process and that singlet oxygen is one but not necessarily the only mediator of the antiviral effects of MC540.
Design of a Broadband HEMT Mixer for UWB Applications (2016)

Background/Objectives: Microwave mixer is a crucial element in virtually all transmits and receives systems. Methods/ Statistical analysis: In this paper, a novel distributed HEMT mixer with three layers is designed for Ultrawide-Band (UWB) receivers. We employ external capacitors in the proposed circuit to adjust the output phase shift between stages to equal the input phase shift. Findings: The simulation results show that the proposed structure, achieves vary broadband performances in Converstion Gain, Power Consumption and LO-RF Isolation, comparable to the recent reported cascode or dual-gate distributed mixers. With a local oscillator power of 12 dBm and RF power of -20 dBm, our mixer has a Conversion Gain of 0 ~ 4 dB (without IF signal amplification), LO-to-RF isolation better than 32 dB and 130 mW DC power consumption over bandwith 5-25 GHz. Applications/Improvements: In our scheme, an intermediate layer is considered to increase LO-RF Isolation and improve the Converstion Gain criterion. Moreover, Microstrip lines are used to form the artificial gate and drain transmission lines as well as phase equalization of the signal on drain transmission line.Keywords: Distributed Mixer, HEMT Mixer, Millimeter-Wave (MMW), Ultra-Wideband, Wireless Communication
Fusion-fission hybrid as an alternative to the fast breeder reactor (1980)

This report compares the fusion-fission hybrid on the plutonium cycle with the classical fast breeder reactor (FBR) cycle as a long-term nuclear energy source. For the purpose of comparison, the current light-water reactor once-through (LWR-OT) cycle was also analyzed. The methods and models used in this study were developed for use in a comparative analysis of conventional nuclear fuel cycles. Assessment areas considered in this study include economics, energy balance, proliferation resistance, technological status, public safety, and commercial viability. In every case the characteristics of all fuel cycle facilities were accounted for, rather than just those of the reactor.
Transforming Growth Factor- β2 Induces Pleurodesis Significantly Faster than Talc (2001)

Transforming growth factor-beta2 (TGF-beta2) has recently been shown to produce effective pleurodesis in rabbits. Conventional pleurodesing agents such as talc act by inducing pleural injury, which results in acute inflammation and fibrosis. TGF-beta2 is a profibrotic cytokine capable of producing fibrosis without inducing significant pleural inflammation. We hypothesize that intrapleural administration of TGF-beta2 would (1) produce an effective pleurodesis faster; (2) stimulate more collagen deposition, and (3) induce less inflammation when compared with intrapleural injection of talc. Thirty rabbits were divided into two groups and given either TGF-beta(2) (1.7 microg) or talc slurry (400 mg/kg) via a chest tube. Five rabbits from each group were killed at Days 1, 4, and 7. Gross pleurodesis was graded from 1 (none) to 8 (complete symphysis). The microscopic pleural inflammation and fibrosis were graded from 0 to 4. Pleural thickening and the total area of collagen deposition were compared. Intrapleural injection of TGF-beta2 produced effective pleurodesis within 7 d (median pleurodesis score = 7 at Day 7). At Day 7, TGF-beta2 induced significantly more collagen deposition (19.4 +/- 19.6% versus 4.6 +/- 2.9% of total area of pleura at Day 7), higher pleural fibrosis score (3.0 +/- 1.0 versus 1.8 +/- 0.5), and pleural thickness (286 +/- 191 versus 85 +/- 37 microm) than did talc. There was no difference in the degree of pleural inflammation between the two groups at Day 7 (2.6 +/- 0.9 for TGF-beta2 versus 2.4 +/- 0.6 for talc) or at any other time points. In conclusion, the intrapleural administration of TGF-beta2 produced excellent pleurodesis in rabbits at a rate faster than talc slurry and all other pleurodesing agents investigated before. TGF-beta2 stimulated more collagen deposition without inducing excess inflammation when compared with talc slurry. TGF-beta2 may have advantages over talc slurry in the management of recurrent pleural effusion and pneumothorax.
Analytic control methods for high-fidelity unitary operations in a weakly nonlinear oscillator (2011)

In qubits made from a weakly anharmonic oscillator the leading source of error at short gate times is leakage of population out of the two dimensional Hilbert space that forms the qubit. In this article we develop a general scheme based on an adiabatic expansion to find pulse shapes that correct this type of error. We find a family of solutions that allows tailoring to what is practical to implement for a specific application. Our result contains and improves the previously developed derivative removal by adiabatic gate technique [F. Motzoi et al., Phys. Rev. Lett. 103, 110501 (2009)] and allows a generalization to other nonlinear oscillators with more than one leakage transition.
Constructing Distributed Hippocratic Video Databases for Privacy-Preserving Online Patient Training and Counseling (2009)

Digital video now plays an important role in supporting more profitable online patient training and counseling, and integration of patient training videos from multiple competitive organizations in the health care network will result in better offerings for patients. However, privacy concerns often prevent multiple competitive organizations from sharing and integrating their patient training videos. In addition, patients with infectious or chronic diseases may not want the online patient training organizations to identify who they are or even which video clips they are interested in. Thus, there is an urgent need to develop more effective techniques to protect both video content privacy and access privacy . In this paper, we have developed a new approach to construct a distributed Hippocratic video database system for supporting more profitable online patient training and counseling. First, a new database modeling approach is developed to support concept-oriented video database organization and assign a degree of privacy of the video content for each database level automatically. Second, a new algorithm is developed to protect the video content privacy at the level of individual video clip by filtering out the privacy-sensitive human objects automatically. In order to integrate the patient training videos from multiple competitive organizations for constructing a centralized video database indexing structure, a privacy-preserving video sharing scheme is developed to support privacy-preserving distributed classifier training and prevent the statistical inferences from the videos that are shared for cross-validation of video classifiers. Our experiments on large-scale video databases have also provided very convincing results.
Modeling Phosphorus Concentrations in Irish Rivers Using Land Use, Soil Type, and Soil Phosphorus Data (2002)

Modeling diffuse phosphorus (P) loss may indicate management strategies to minimize P loss from agricultural sources. An empirical model predicting flow-weighted phosphorus concentrations (MRP) was derived using data collected from 35 Irish river catchments. Monitoring records of riverine P and stream flow data were used to calculate MRP values averaged for the years 1991–1994. These data were modeled using land use, soil type, and soil P data. Soil type in catchments was described using soil survey classifications weighted according to their P desorption properties from laboratory results. Soil test P concentrations for the studied watersheds were obtained from a national database. Soil P levels were weighted based on the results of field experiments measuring P losses in overland flow from fields at different soil test P levels. The 35 catchments were statistically clustered into two populations (A and B) based on differences in soil type, specifically, soil hydrology. Catchments in Cluster A had predominantly poorly drained soils and comparatively higher MRP concentrations (0.03–0.17 mgL−1) than Cluster B areas (0.01–0.7 mgL−1) with mostly well-drained soils. Regression equations derived for A and B type catchments predicted MRP values with 68 and 62% of the variation explained in the models, respectively. Data extracted for the rest of the country were applied to the models to delineate areas at risk on a national scale. While the models were only moderately accurate they highlighted the influence of land management, specifically, high production grassland receiving high P inputs, in conjunction with the effect of soil type and soil hydrology on the transport of P to surface waters.
Influences of Layering Process on Theophylline Pellet Characteristics (2004)

This study evaluated and compared theophylline pellets prepared by both suspension and powder layering processes using the bottom spray coater and the tangential rotary granulator, respectively. Hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) were employed as binders at various concentrations. The pellets were coated with Eudragit RS and RL to various levels. It was found that pellet sizes, true densities, and drug contents were comparable and independent of processes and binder levels. However, the increase in binder resulted in lower porosity and pore size, as well as smoother pellet surface. The powder layered pellets possessed higher pellet density and smoother surface than did the suspension layered pellets due to the greater consolidation resulted from tumbling and colliding of pellets. Powder x-ray diffraction pattern revealed that theophylline present in the suspension layered pellets was a mixture of anhydrous form II and hydrate, indicating that transformation could occur in aqueous medium. Drug release from uncoated pellets was found to be complete within 20 min. For coated pellets, the release was markedly decreased with the increase in Eudragit level. Both film thickness and anhydrous/hydrate form influenced the release of drug from the pellets. In general, two methods of layering produced the pellets of slightly differences in pellet properties; however, changes of drug characteristics could occur in suspension.