gebhart/patrepeval huggingface dataset:
Characterization of a human chorionic gonadotropin-like protein from Candida albicans (1993)

Studies from our laboratory have demonstrated that human CG (hCG), human LH, (hLH), and an hCG-like protein extracted from Xanthomonas maltophilia were able to induce Candida albicans transition from the blastospore to the germ tube stage. In the present study, we describe the characterization of an hCG-like material extracted from Candida albicans blastospores (CaCGLP), which is potent in inducing transition and presumably represents the endogenous transition-inducing substance. This material was extracted from Candida albicans blastospores with glacial acetic acid and purified by affinity chromatography using a polyclonal rabbit anti-hCG antibody. The product obtained is a 68-kilodalton single band protein, as analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis. Under reduced conditions a protein smear is seen. Amino acid analysis showed a predominance of glycine (22%), followed by serine (12%), and glutamate (12%). This protein reacted in the following hCG immunoassays: 1) a polyclonal rabbit anti-hCG equilibrium assay, 2) a carboxyl-tail hCG equilibrium assay, 3) two hCG equilibrium assays using monoclonal antibodies (CG no. 4 and CG no. 9), 4) a free alpha-subunit equilibrium assay using a monoclonal antibody, and 5) an ultrasensitive immunoradiometric assay for hCG which does not cross-react with hLH, nor the free beta-subunit of hCG. The CaCGLP showed no reaction in a specific hLH immunoradiometric assay. When CaCGLP was tested in the transition assay, in the presence of 4% rat serum, it was found that this protein was 100 times more potent than hCG in producing Candida albicans transition. We conclude that Candida albicans produces a protein that has certain tertiary structure similarities to hCG and that this material is able to induce germ tube formation. We postulate that CaCGLP has an autocrine/paracrine effect in Candida albicans as a transition factor to control its own pathogenicity.
ChemInform Abstract: SYNTHESIS OF N‐(3‐AMINO‐2‐HYDROXY PROPYL)‐N‐SULFONYLANILINES DERIVATIVES. POTENTIAL ANTIANGINAL ACTIVITIES (1981)

Abstract Titelverbindungen vom Typ (I)‐(IV) wurden nach Literatur‐Metho‐ den synthetisiert und auf ihre β‐ und /oder α‐antiadrenergischen Eigenschaften ‐ in Beziehung zu den Strukturen ‐ untersucht.
Cost-based variable-length-gram selection for string collections to support approximate queries efficiently (2008)

Approximate queries on a collection of strings are important in many applications such as record linkage, spell checking, and Web search, where inconsistencies and errors exist in data as well as queries. Several existing algorithms use the concept of "grams," which are substrings of strings used as signatures for the strings to build index structures. A recently proposed technique, called VGRAM, improves the performance of these algorithms by using a carefully chosen dictionary of variable-length grams based on their requencies in the string collection. Since an index structure using fixed-length grams can be viewed as a special case of VGRAM, a fundamental problem arises naturally: what is the relationship between the gram dictionary and the performance of queries? We study this problem in this paper. We propose a dynamic programming algorithm for computing a tight lower bound on the number of common grams shared by two similar strings in order to improve query performance. We analyze how a gram dictionary affects the index structure of the string collection and ultimately the performance of queries. We also propose an algorithm for automatically computing a dictionary of high-quality grams for a workload of queries. Our experiments on real data sets show the improvement on query performance achieved by these techniques. To our best knowledge, this study is the first cost-based quantitative approach to deciding good grams for approximate string queries.
Short Video Datasets Show Potential for Outfits in Augmented Reality (2019)

We investigate the usage of short video datasets in place of large image datasets for outfit transfer. We replicate the warp stage of prior work, SwapNet, while swapping out the 800K-image DeepFashion dataset for two 5-minute videos. By successfully training the warp stage on video, we show that the previously proposed transfer technique for images has potential to apply to subjects in motion. In addition, specifically for video applications, we show the model need not be trained on a comprehensive dataset; instead the model only needs videos for the source outfit and target subject. Our results show promise for the usage of video datasets in future work to achieve fully-textured outfit transfer. We expect the implications of convenient-to-collect video datasets to appeal to small companies that lack resources to collect and annotate big data. If combined with high performance computing, faster training times in the cloud could lead to frictionless user experiences.
Suppressing the Chills: Effects of Musical Manipulation on the Chills Response (2018)

Research on musical chills has linked the response to multiple musical features; however, there exists no study that has attempted to manipulate musical stimuli to enable causal inferences, meaning current understanding is based mainly on correlational evidence. In the current study, participants who regularly experience chills (<i>N</i> = 24) listened to an original and manipulated version of three pieces reported to elicit chills in a previous survey. Predefined chills sections were removed to create manipulated conditions. The effects of these manipulations on the chills response were assessed through continuous self-reports, and skin conductance measurements. Results show that chills were significantly less frequent following stimulus manipulation across all three pieces. Continuous measurements of chills intensity were significantly higher in the chills sections compared with control sections in the pieces; similar patterns were found for phasic skin conductance, although some differences emerged. Continuous measurements also correlated with psychoacoustic features such as loudness, brightness and roughness in two of the three pieces. Findings are discussed in terms of understanding structural and acoustic features and chills experiences within their local music contexts, the necessity of experimental approaches to musical chills, and the possibility of different features activating different underlying mechanisms.
Functional, endogenously expressed 5‐hydroxytryptamine 5‐ht<sub>7</sub> receptors in human vascular smooth muscle cells (1996)

Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50 values of 7.12 and 6.25, sumatriptan being very weakly active. Both methiothepin (0.1 microM) and clozapine (1 microM), but not the 5-HT4-receptor antagonist, SDZ 205-557 (10 microM) antagonized the effects of 5-CT. In reverse transcriptase-polymerase chain reaction analysis, the mRNA for 5-ht7, but not for 5-HT4 or 5-ht6 receptors was found to be strongly expressed in the same cells. These findings represent a further step toward the recognition of 5-ht7 receptors as real, functional receptors.
The research on Outlook password recovery (2013)

Outlook is the email client in the Microsoft office package, which has become one of the most widely applied email processing systems in the personal and commercial office environment. This paper studies the password recovery for various accounts in Outlook and we find the method of online recovery by exploiting the Windows cryptographic interface DPAPI for sensitive data. This recovery method enables one to retrieve his password very conveniently. Furthermore, we investigate the inner workings of encryption and decryption functions in DPAPI and present a detailed analysis on the encrypted data type, storage structure, cryptographic algorithm and key generation. To the best of our knowledge, for the first time we give the way of offline password recovery which could be remarkably helpful in the computer forensics.
Modeling of the Sagittal Cervical Spine as a Method to Discriminate Hypolordosis (2004)

The mean cervical lordosis for all groups could be closely modeled with a circle. Pain groups had hypolordosis and larger radiuses of curvature compared with the normal group. Circular modeling may be a valuable tool in the discrimination between normal lordosis and hypolordosis in normal and pain subjects.
Complementary hemispheric specialization for language production and visuospatial attention (2013)

Language production and spatial attention are the most salient lateralized cerebral functions, and their complementary specialization has been observed in the majority of the population. To investigate whether the complementary specialization has a causal origin (the lateralization of one function causes the opposite lateralization of the other) or rather is a statistical phenomenon (different functions lateralize independently), we determined the lateralization for spatial attention in a group of individuals with known atypical right hemispheric (RH) lateralization for speech production, based on a previous large-scale screening of left-handers. We show that all 13 participants with RH language dominance have left-hemispheric dominance for spatial attention, and all but one of 16 participants with left-hemispheric language dominance are RH dominant for spatial attention. Activity was observed in the dorsal fronto-parietal pathway of attention, including the inferior parietal sulcus and superior parietal lobule, the frontal eye-movement field, and the inferior frontal sulcus/gyrus, and these regions functionally colateralized in the hemisphere dominant for attention, independently of the side of lateralization. Our results clearly support the Causal hypothesis about the complementary specialization, and we speculate that it derives from a longstanding evolutionary origin. We also suggest that the conclusions about lateralization based on an unselected sample of the population and laterality assessment using coarse functional transcranial Doppler sonography should be interpreted with more caution.
Engineering near-infrared single-photon emitters with optically active spins in ultrapure silicon carbide (2015)

Vacancy-related centres in silicon carbide are attracting growing attention because of their appealing optical and spin properties. These atomic-scale defects can be created using electron or neutron irradiation; however, their precise engineering has not been demonstrated yet. Here, silicon vacancies are generated in a nuclear reactor and their density is controlled over eight orders of magnitude within an accuracy down to a single vacancy level. An isolated silicon vacancy serves as a near-infrared photostable single-photon emitter, operating even at room temperature. The vacancy spins can be manipulated using an optically detected magnetic resonance technique, and we determine the transition rates and absorption cross-section, describing the intensity-dependent photophysics of these emitters. The on-demand engineering of optically active spins in technologically friendly materials is a crucial step toward implementation of both maser amplifiers, requiring high-density spin ensembles, and qubits based on single spins.
Noise-based monitoring and imaging of aseismic transient deformation induced by the 2006 Basel reservoir stimulation (2015)

ABSTRACT We have analyzed the time-dependent properties of the ambient seismic wavefield between 0.1 and 8 Hz to detect, resolve, monitor, and image the deformation induced by the water injection associated with the stimulation of the 2006 Deep Heat Mining Project in the city of Basel, Switzerland. The application of passive methods allowed the detection of an aseismic transient of approximately 35 days’ duration that began with the onset of the reservoir stimulation. Peak deformation was reached some 15 days after the bleed-off and after the induced seismicity ceased. We resolved a significant increase in seismic velocities and a simultaneous decorrelation of the noise correlation coda waveforms. The wavefield properties implied that the material response was monitored mainly in the sedimentary layer (&lt;2.5 km) above the stimulated volume that was approximately 4.5 km deep. We inverted the velocity-change and decorrelation data to estimate the spatial distribution of the medium changes. The resulting images showed that the strong velocity variations and medium perturbations were generally colocated with the lateral distribution of the induced seismicity. Positive velocity changes and damage around the injection site indicated subsidence, settling, and compaction of the material overlying the stimulated volume. Our results demonstrate that noise-based analysis tools can provide important observables that are complementary to results obtained with standard microseismicity tools. Passive monitoring and imaging have the potential to mature into routinely applied observation techniques that support reservoir management in a variety of geotechnical contexts, such as for mining, fluid injection, hydraulic fracturing, nuclear waste management, and CO2 storage.
80-Mb/s QPSK and 72-Mb/s 64-QAM flexible and scalable digital OFDM transceiver ASICs for wireless local area networks in the 5-GHz band (2001)

With the advent of mobile communications, voice telecommunications became wireless. Future applications, however, target multimedia, messaging, and high-speed Internet access, all expressing the need for a broadband high-speed wireless access technique. Both the domestic multimedia and the wireless local area network (WLANs) business markets are addressed. Established systems deliver 2-11 Mb/s based on spectrally inefficient spread-spectrum techniques, where scalability has reached a limit. The next generation of modems requires spectrally more efficient low-power and highly integrated solutions. We describe here the design of two digital baseband orthogonal frequency division multiplex (OFDM) signal processing ASICs, implementing respectively a quaternary phase-shift keying (QPSK)-based 80-Mb/s and a 64 quadrature amplitude modulation (QAM)-based 72-Mb/s digital inner transceiver. The latter partially matches the Hiperlan/2 and IEEE 802.11a standards. Joint development of signal processing algorithms and architectures along with on-chip data transfer, control, and partitioning leads to a low-power, yet flexible and scalable implementation. Both ASICs were designed in a unique object-oriented C++ design flow starting from algorithm level. The ASICs were successfully tested in a 5-GHz testbed both for file data transfer and web-cam multimedia transmission.
Synthesis of thermoplastic poly(ester-siloxane)s in the melt and in solution (2005)

Two series of thermoplastic elastomers, based on poly(dimethylsiloxane) PDMS, as the soft segment and poly(butylene terephthalate), PBT, as the hard segment, were synthesized by catalyzed transesterification, from dimethyl terephthalate, DMT, silanol-terminated poly(dimethylsiloxane), PDMS-OH Mn=1750g/mol, and 1,4-butanediol, BD. The mole ratio of the starting comonomers was selected to result in a constant hard to soft weight ratio of 55:45. The first series was synthesized in order to determine the optimal mole ratio of BD and DMT for the synthesis of high molecular weight thermoplastic poly(ester-siloxane)s, TPESs. The second series was performed in the presence of the high-boiling solvent, 1,2,4-trichlorbenzene in order to increase the mixing between the extremely non-polar siloxane prepolymer and the polar reactants, DMT and BD, and, therefore, avoid phase separation during synthesis. The structure and composition of the synthesized poly(ester-siloxane)s were verified by 1H-NMR spectroscopy, while the melting temperatures and degree of crystallinity were determined by differential scanning calorimetry (DSC). The effectiveness of the incorporation of the silanol-terminated poly( dimethylsiloxane) into the polyester chains was verified by chloroform extraction. The rheological properties of the poly(ester-siloxane)s were investigated by dynamic mechanical spectroscopy (DMA).
A sustainable resistive switching memory device based on organic keratin extracted from hair (2019)

It is the consensus of researchers that the reuse of natural resources is an effective way to solve the problems of environmental pollution, waste and overcapacity. Moreover, compared with the case of inorganic materials, the renewability of natural biomaterials has great prominent advantages. In this study, keratin, which was first extracted from hair due to its high content in hair, was chosen as a functional layer for the fabrication of a resistance switching device with the Ag/keratin/ITO structure; in this device, a stable resistive switching memory behavior with good retention characteristic was observed. <i>Via</i> mechanism analysis, it is expected that there is hopping conduction at low biases, and the formation of a conductive filament occurs at high biases. Furthermore, our device exhibited a stable switching behavior with different conductive materials (Ti and FTO) as bottom electrodes, and the influence of Ag and graphite conductive nanoparticles (NPs) doped into the keratin layer on the switching performance of the device was also investigated. This study not only suggests that keratin is a potential biomaterial for the preparation of memory devices, but also provides a promising route for the fabrication of bio-electronic devices with non-toxicity, degradability, sustainability <i>etc.</i>
Qualitative evaluation of aromatic herbs by direct headspace GC analysis. Applications of the method and comparison with the traditional analysis of essential oils (1982)

Abstract GC headspace analyses of various aromatizing herbs have been compared with those relating to the essential oils, obtained by steam distillation, of the same plants. In this way it was possible to establish the most significant differences between the composition of a herb flavor and that of its essential oil. In particular, we observed some very volatile compounds in the headspace samples which were absent from the essential oil; these components may make an important contribution to the herb flavor. The identification of these substances is still in progress.
A stepped-plate bi-frequency source for generating a difference frequency sound with a parametric array (2010)

An ultrasonic radiator is developed to generate a difference frequency sound from two frequencies of ultrasound in air with a parametric array. A design method is proposed for an ultrasonic radiator capable of generating highly directive, high-amplitude ultrasonic sound beams at two different frequencies in air based on a modification of the stepped-plate ultrasonic radiator. The stepped-plate ultrasonic radiator was introduced by Gallego-Juarez et al. [Ultrasonics 16, 267-271 (1978)] in their previous study and can effectively generate highly directive, large-amplitude ultrasonic sounds in air, but only at a single frequency. Because parametric array sources must be able to generate sounds at more than one frequency, a design modification is crucial to the application of a stepped-plate ultrasonic radiator as a parametric array source in air. The aforementioned method was employed to design a parametric radiator for use in air. A prototype of this design was constructed and tested to determine whether it could successfully generate a difference frequency sound with a parametric array. The results confirmed that the proposed single small-area transducer was suitable as a parametric radiator in air.
Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear<i> In Vivo</i> (2016)

Mammalian inner ear harbors diverse cell types that are essential for hearing and balance. Adenovirus is one of the major vectors to deliver genes into the inner ear for functional studies and hair cell regeneration. To identify adenovirus vectors that target specific cell subtypes in the inner ear, we studied three adenovirus vectors, carrying a reporter gene encoding green fluorescent protein <i>(GFP)</i> from two vendors or with a genome editing gene Cre recombinase <i>(Cre)</i>, by injection into postnatal days 0 (P0) and 4 (P4) mouse cochlea through scala media by cochleostomy <i>in vivo</i>. We found three adenovirus vectors transduced mouse inner ear cells with different specificities and expression levels, depending on the type of adenoviral vectors and the age of mice. The most frequently targeted region was the cochlear sensory epithelium, including auditory hair cells and supporting cells. Adenovirus with <i>GFP</i> transduced utricular supporting cells as well. This study shows that adenovirus vectors are capable of efficiently and specifically transducing different cell types in the mammalian inner ear and provides useful tools to study inner ear gene function and to evaluate gene therapy to treat hearing loss and vestibular dysfunction.
Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein (2015)

Filoviruses are among the most deadly human pathogens. The 2014-2015 outbreak of Ebola virus disease (EVD) led to more than 27,000 cases and 11,000 fatalities. While there are five species of Ebolavirus and several strains of marburgvirus, the current immunotherapeutics primarily target Ebola virus. Since the nature of future outbreaks cannot be predicted, there is an urgent need for therapeutics with broad protective efficacy against multiple filoviruses. Here we describe a set of monoclonal antibodies cross-reactive with multiple filovirus species. These antibodies target novel conserved epitopes within the envelope glycoprotein and exhibit protective efficacy in mice. We further present novel concepts for combination of cross-reactive antibodies against multiple epitopes that show enhanced efficacy compared to monotherapy and provide complete protection in mice. These findings set the stage for further evaluation of these antibodies in nonhuman primates and development of effective pan-filovirus immunotherapeutics for use in future outbreaks.
Panel: The Impact of the World Wide Web on Electronic Design and EDA (1995)

A review of the explosion of Internet-accessible World-Wide Web servers and their impact on Electronic Design and Design Automation. Also a discussion of how internal Web Servers, such as those run by CAE managers at Cisco, and Silicon Graphics, interact with vendor (e.g. Cadence, Marshall, and Synopsys) and university servers (e.g. SIGDA). The World-Wide Web is enabling the delivery of product documentation, software, software patches, demo software, newspaper articles, part information, magazine articles, quotations, and much more to the engineer's desktop. Panel members will briefly describe how their organization is using WWW technology and then give their observations and speculations on how it has affected and will affect electronic design methodology and business practices.
Designing and managing drilling fluid (1994)

Drilling fluid, or mud, can contribute to virtually any drilling problem. Stuck pipe, poor completion, inadequate logs and production difficulties may all be laid at mud's door. In recent years, oil-base mud (OBM) successfully eliminated many of these concerns, but environmental regulations increasingly limit its use. Attention is paid to the issues that must now be considered when designing a mud program without OBM. New types of drilling fluid are dealt with. It is examined how improved drilling fluids management can yield substantial efficiency benefits. 11 figs., 40 refs.