gebhart/patrepeval huggingface dataset:
Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children (2015)

Poorly managed diet and genetic mutations are the two primary driving forces behind the devastating epidemic of obesity-related diseases. Lack of understanding of the molecular chain of causation between the driving forces and the disease endpoints retards progress in prevention and treatment of the diseases. We found that children genetically obese with Prader-Willi syndrome shared a similar dysbiosis in their gut microbiota with those having diet-related obesity. A diet rich in non-digestible but fermentable carbohydrates significantly promoted beneficial groups of bacteria and reduced toxin-producers, which contributes to the alleviation of metabolic deteriorations in obesity regardless of the primary driving forces.
Sub-polyhedral scheduling using (unit-)two-variable-per-inequality polyhedra (2013)

Polyhedral compilation has been successful in the design and implementation of complex loop nest optimizers and parallelizing compilers. The algorithmic complexity and scalability limitations remain one important weakness. We address it using sub-polyhedral under-aproximations of the systems of constraints resulting from affine scheduling problems. We propose a sub-polyhedral scheduling technique using (Unit-)Two-Variable-Per-Inequality or (U)TVPI Polyhedra. This technique relies on simple polynomial time algorithms to under-approximate a general polyhedron into (U)TVPI polyhedra. We modify the state-of-the-art PLuTo compiler using our scheduling technique, and show that for a majority of the Polybench (2.0) kernels, the above under-approximations yield polyhedra that are non-empty. Solving the under-approximated system leads to asymptotic gains in complexity, and shows practically significant improvements when compared to a traditional LP solver. We also verify that code generated by our sub-polyhedral parallelization prototype matches the performance of PLuTo-optimized code when the under-approximation preserves feasibility.
Clinical validation of S100B use in management of mild head injury (2012)

The clinical use of S100B within our existing guidelines for management of MHI is safe and effective. Adult MHI patients, without additional risk factors and with normal S100B levels within 3 hours of injury, can safely be discharged from the hospital.
<em>In vivo</em> Imaging Method to Distinguish Acute and Chronic Inflammation (2013)

Inflammation is a fundamental aspect of many human diseases. In this video report, we demonstrate non-invasive bioluminescence imaging techniques that distinguish acute and chronic inflammation in mouse models. With tissue damage or pathogen invasion, neutrophils are the first line of defense, playing a major role in mediating the acute inflammatory response. As the inflammatory reaction progresses, circulating monocytes gradually migrate into the site of injury and differentiate into mature macrophages, which mediate chronic inflammation and promote tissue repair by removing tissue debris and producing anti-inflammatory cytokines. Intraperitoneal injection of luminol (5-amino-2,3-dihydro-1,4-phthalazinedione, sodium salt) enables detection of acute inflammation largely mediated by tissue-infiltrating neutrophils. Luminol specifically reacts with the superoxide generated within the phagosomes of neutrophils since bioluminescence results from a myeloperoxidase (MPO) mediated reaction. Lucigenin (bis-N-methylacridinium nitrate) also reacts with superoxide in order to generate bioluminescence. However, lucigenin bioluminescence is independent of MPO and it solely relies on phagocyte NADPH oxidase (Phox) in macrophages during chronic inflammation. Together, luminol and lucigenin allow non-invasive visualization and longitudinal assessment of different phagocyte populations across both acute and chronic inflammatory phases. Given the important role of inflammation in a variety of human diseases, we believe this non-invasive imaging method can help investigate the differential roles of neutrophils and macrophages in a variety of pathological conditions.
Diverse Essential Functions Revealed by Complementing Yeast Calmodulin Mutants (1994)

Calmodulin, a cytoplasmic calcium-binding protein, is indispensable for eukaryotic cell growth. Examination of 14 temperature-sensitive yeast mutants bearing one or more phenylalanine to alanine substitutions in the single essential calmodulin gene of yeast (CMD1) revealed diverse essential functions. Mutations could be classified into four intragenic complementation groups. Each group showed different characteristic functional defects in actin organization, calmodulin localization, nuclear division, or bud emergence. Phenylalanine residues implicated in calmodulin localization and nuclear division are located in the amino-terminal half of the protein, whereas those implicated in actin organization and bud emergence are located in the carboxyl-terminal half.
Høyesterett eller Efta-domstolen?Öppet gräl om vem som bestämmer (2013)

Ett oppet gral har brutit ut mellan Efta-domstolen och Norges Hoyesterett efter domen i det sa kallade varvsmalet i borjan av aret. Ordvaxlingen pagar i saval domskal som debatt-artiklar och handla ...
Resolving Bipolar Electrogram Voltages During Atrial Fibrillation Using Omnipolar Mapping (2017)

Omnipolar EGMs can extract maximal voltages from AF signals which are not influenced by directional factors, collision or fractionation, compared with contemporary bipolar techniques.
Fabrication of two-dimensional staggered silver nanosheets on an aluminium foil (2005)

Two-dimensional staggered silver nanosheets (NSs) immobilized on a flat aluminium foil have been synthesized by keeping the underside surface of the foil in contact with the solution of normal silver mirror reaction. The NSs are hundreds of nanometres to several micrometres in dimensions and tens of nanometres in thickness. The effects of the aluminium foil, a chemically active substrate, on the orientation growth of silver nanosheets has been revealed. The results demonstrated that the growth and the morphology control of the silver nanostructure were simply realized in one process by the introduction of a chemically active substrate.
Formulating Spatially Varying Performance in the Statistical Fusion Framework (2012)

To date, label fusion methods have primarily relied either on global [e.g., simultaneous truth and performance level estimation (STAPLE), globally weighted vote] or voxelwise (e.g., locally weighted vote) performance models. Optimality of the statistical fusion framework hinges upon the validity of the stochastic model of how a rater errs (i.e., the labeling process model). Hitherto, approaches have tended to focus on the extremes of potential models. Herein, we propose an extension to the STAPLE approach to seamlessly account for spatially varying performance by extending the performance level parameters to account for a smooth, voxelwise performance level field that is unique to each rater. This approach, Spatial STAPLE, provides significant improvements over state-of-the-art label fusion algorithms in both simulated and empirical data sets.
Koda-Kimble and Young's Applied Therapeutics: The Clinical Use of Drugs (2012)

koda-kimble and young's applied therapeutics:the clinical use of drugs , koda-kimble and young's applied therapeutics:the clinical use of drugs , کتابخانه الکترونیک و دیجیتال - آذرسا
A decade of dynamic web content: a structured survey on past and present practices and future trends (2006)

The shift from static to dynamic Web content has been dramatic. Dynamic Web content is facilitated by specialized cooperating component systems better known as content middlewares. Unlike static content, the generation and delivery of dynamic Web content introduce heavy a workload on content middlewares. To address this problem, numerous research approaches have been proposed in the literature, some of which are the driving force behind popular commercial systems, a fact that stresses the importance and applicability of this research area. This article surveys the literature during the period of 1995‐2005 on accelerating the generation and delivery of dynamic Web content. It classifies the proposed approaches into taxonomies based on their underlying methodologies and practices. In order to illustrate the evolution of research, we introduce a research-charting semi-formal framework called the Caching Fragmentation Polymorphism (CFP) framework, within which we relate the surveyed approaches and depict their relationships.
Studies of organosilicon chemistry. 107. N-(silylmethyl)-substituted ketene N,S-acetals as a synthetic equivalent of a novel 1,3-dipolar reagent, alkylideneazomethine ylides: synthesis and [3 + 2] cycloadditions (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of organosilicon chemistry. 107. N-(silylmethyl)-substituted ketene N,S-acetals as a synthetic equivalent of a novel 1,3-dipolar reagent, alkylideneazomethine ylides: synthesis and [3 + 2] cycloadditionsAkira Hosomi, Yuji Miyashiro, Ryoji Yoshida, Yoshinori Tominaga, Toshiharu Yanagi, and Makoto HojoCite this: J. Org. Chem. 1990, 55, 19, 5308–5310Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/jo00306a004https://doi.org/10.1021/jo00306a004research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Finite element analysis of ladle turret (2008)

The paper built the 3D model of 320 t ladle turret using Inventor software and carried out finite element analysis by ABAQUS.The results of finite element analysis have role in technical guidance for turret design,improvement and the final scheme determination.The largest vertical displacement of ladle turret is consistent with the finite element analysis,which showed the model is reasonable,and demonstrates the importance of the CAE and finite element analysis in the design of ladle turret.
Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-Containing Analogues of RA-VII, an Antitumor Bicyclic Hexapeptide from <i>Rubia</i> Plants (2004)

Three analogues of RA-VII (1), an antitumor bicyclic hexapeptide from Rubia plants, were synthesized. Three analogues, [Gly-1]RA-VII (4), [Gly-2]RA-VII (5), and [Gly-4]RA-VII (6), in which one of the three alanine residues in 1 was replaced by a glycine residue, were prepared by linking of the cycloisodityrosine unit, obtained by degradation of 1, to three different glycine-containing tetrapeptides followed by macrocyclization. Of these three analogues, analogue 4 showed the highest cytotoxic activity. The NMR study revealed that in solution the conformer structures and their ratios of analogue 4 were very similar to those of natural peptide 1, suggesting that the methyl groups at Ala-2 and Ala-4 should be essential for producing the bioactive conformation, whereas that at D-Ala-1 is not essential.
Diagnostic tests in neonatal sepsis (2008)

A better understanding of the neonatal inflammatory response to sepsis and identification of sensitive and specific markers of inflammation or rapid microbe-specific diagnostic tests would assist in the early detection of neonatal sepsis and in safely withholding antibiotics for patients in whom sepsis is unlikely.
A microporous six-fold interpenetrated hydrogen-bonded organic framework for highly selective separation of C<sub>2</sub>H<sub>4</sub>/C<sub>2</sub>H<sub>6</sub> (2014)

A unique six-fold interpenetrated hydrogen-bonded organic framework (HOF) has been developed, for the first time, for highly selective separation of C2H4/C2H6 at room temperature and normal pressure.
Bacteriological composition and structure of granular sludge adapted to different substrates (1991)

The bacteriological composition and ultrastructure of mesophilic granular methanogenic sludge from a large-scale Upflow Anaerobic Sludge Blanket reactor treating wastewater from a sugar plant and of sludge granules adapted to ethanol and propionate were studied by counting different bacterial groups and by immunocytochemical methods. Propionate-grown granular sludge consisted of two types of clusters, those of a rod-shaped bacterium immunologically related to Methanothrix soehngenii and those consisting of two different types of bacteria with a specific spatial orientation. One of these bacteria reacted with antiserum against Methanobrevibacter arboriphilus AZ, whereas the other is most likely a propionate-oxidizing bacterium immunologically unrelated to Syntrophobacter wolinii. Sludge granules obtained from the large-scale Upflow Anaerobic Sludge Blanket reactor and granules cultivated on ethanol did not show the typical spatial orientation of bacteria. Examination of the bacterial composition of the three types of granules by light and electron microscopy, the most-probable-number method, and by isolations showed that M. arboriphilus and M. soehngenii were the most abundant hydrogenotrophic and acetoclastic methanogens in propionate-grown sludge. Methanospirillum hungatei and Methanosarcina barkeri predominated in ethanol-grown granules, whereas many morphotypes of methanogens were abundant in granules from the full-scale reactor.
Application of JVD nitride gate dielectric to a 0.35 micron CMOS process for reduction of gate leakage current and boron penetration (2002)

The increase in gate leakage current and boron penetration are major problems for scaled gate dielectrics in advanced device technology. We have demonstrated, for the first time, reduction in gate leakage current and strong resistance to boron penetration when Jet Vapor Deposition (JVD) nitride is used as a gate dielectric in an advanced CMOS process. JVD nitride provides a robust interface and well behaved bulk properties, MOSFET characteristics, and ring oscillator performance. Process optimization and manufacturing issues remain to be addressed.
ChemInform Abstract: Aquathermolysis: Reactions of Organic Compounds with Superheated Water (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
PMMA polymer film characterization using thickness-shear mode (TSM) quartz resonator (2003)

Poly(methyl methacrylate) (PMMA) polymer films can be used either as a chemically sensitive coating material in implementing biochemical sensors or as a waveguiding layer in guided shear-horizontal surface acoustic wave (SH-SAW) sensor platforms. Characteristic information about the viscoelastic properties of the polymer film and subsequent changes upon exposure to environmental factors is critical for the design, implementation, and analysis of these sensors. The use of the thickness shear mode (TSM) quartz resonator is proposed here to rapidly determine the mechanical properties, primarily the complex shear modulus (G=G'+G") of relatively thin organic polymer films because of its simplicity and ability to support shear horizontal waves, which are ideal for the characterization of the complex shear modulus of thin films. Using the near-resonant electrical characteristics of the coated device, the impedance/admittance characteristics of the equivalent circuit models of both the bare and coated resonators are related to the film properties and subsequent changes in film properties, particularly the storage and loss moduli (G', G"). Both cured and uncured polymer films were studied under different conditions. Measurements and analyses were also performed at higher harmonics for the TSM resonance, in addition to the fundamental frequency, to inspect any frequency-dependent effects and increase the "effective" thickness of the PMMA films.
Combination of Transient Lymphodepletion With Busulfan and Fludarabine and Peptide Vaccination in a Phase I Clinical Trial for Patients With Advanced Melanoma (2007)

Taking advantage of homeostatic mechanisms to boost tumor-specific cellular immunity is raising increasing interest in the development of therapeutic strategies in the treatment of melanoma. Here, we have explored the potential of combining homeostatic proliferation, after transient immunosuppression, and antigenic stimulation of Melan-A/Mart-1 specific CD8 T-cells. In an effort to develop protocols that could be readily applicable to the clinic, we have designed a phase I clinical trial, involving lymphodepleting chemotherapy with Busulfan and Fludarabine, reinfusion of Melan-A specific CD8 T-cell containing peripheral blood mononuclear cells (exempt of growth factors), and Melan-A peptide vaccination. Six patients with advanced melanoma were enrolled in this outpatient regimen that demonstrated good feasibility combined with low toxicity. Consistent depletion of lymphocytes with persistent increased CD4/CD8 ratios was induced, although the proportion of circulating CD4 regulatory T-cells remained mostly unchanged. The study of the immune reconstitution period showed a steady recovery of whole T-cell numbers overtime. However, expansion of Melan-A specific CD8 T-cells, as measured in peripheral blood, was mostly inconsistent, accompanied with marginal phenotypic changes, despite vaccination with Melan-A/Mart-1 peptide. On the clinical level, 1 patient presented a partial but objective antitumor response following the beginning of the protocol, even though a direct effect of Busulfan/Fludarabine cannot be completely ruled out. Overall, these data provide further ground for the development of immunotherapeutic approaches to be both effective against melanoma and applicable in clinic.
A pattern matching and clustering based approach for supporting requirements transformation (2002)

One problem in requirements transformation from informal prose requirements to formal specifications is natural language processing. Although natural language understanding is still not practical for general requirements processing, syntactical information is useful for concept extraction. This paper discusses the correspondence between requirements sentence structure patterns and the events/transition concepts. It addresses how this correspondence might be utilized to extract events and transitions from conditional sentences. A pattern matching and clustering based approach is proposed to support event and transition extraction. The approach first selects requirements that are likely to contain event/transition information and then groups similar requirements to extract events. Once events are identified, the original requirements are clustered based on events to identify, related transition information. The approach is simple and does not require a parser.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ReClick - A Modular Dataplane Design Framework for FPGA-Based Network Virtualization (2011)

Network virtualization has emerged as a powerful technique to deploy novel services and experimental protocols over shared network infrastructures. Although recent research has highlighted field programmable gate arrays (FPGAs) as attractive platforms for high performance network virtualization, these devices remain inaccessible to the larger networking research community due to the absence of user-friendly programming models. A programming model that can abstract the intricacies of the hardware platform while being aware of the underlying resource constraints is highly desirable. In this paper, we present ReClick, a framework to efficiently design and deploy reconfigurable data planes for FPGA-based network virtualization systems. A hardware-agnostic programming model is described that allows developers to focus on the virtual data plane semantics rather than the implementation details. The framework exposes interfaces similar to the popular software router development framework, Click, and promotes design reuse. Optimization strategies are included in ReClick which use similarities between virtual data plane configurations to implement multiple planes in an area-efficient manner. Data planes exhibiting up to 1 Gbps data rate have been automatically compiled and tested in hardware in a Net FPGA platform.
Iron-Based Layered Superconductor:  LaOFeP (2006)

We report superconductivity in an iron-based layered oxy-pnictide LaOFeP. LaOFeP is composed of an alternate stack of lanthanum oxide (La3+O2-) and iron pnictide (Fe2+P3-) layers. Magnetic and electrical resistivity measurements verify the occurrence of the superconducting transition at approximately 4 K.
Downstream Activation of a TATA-less Promoter by Oct-2, Bob1, and NF-κB Directs Expression of the Homing Receptor BLR1 to Mature B Cells (1998)

The chemokine receptor, BLR1, is a major regulator of the microenvironmental homing of B cells in lymphoid organs. In vitro studies identify three essential elements of the TATA-less blr1 core promoter that confer cell type- and differentiation-specific expression in the B cells of both humans and mice, a functional promoter region (-36 with respect to the transcription start site), a NF-kappaB motif (+44), and a noncanonical octamer motif (+157). The importance of these sites was confirmed by in vivo studies in gene-targeted mice deficient of either Oct-2, Bob1, or both NF-kappaB subunits p50 and p52. In all of these animals, the expression of BLR1 was reduced or absent. In mice deficient only of p52/NF-kappaB, BLR1 expression was unaffected. Thus our data demonstrate that BLR1 is a target gene for Oct-2, Bob1, and members of the NF-kappaB/Rel family and provides a link to the impaired B cell functions in mice deficient for these factors.
Regulation of microRNA Expression: the Hypoxic Component (2007)

microRNAs are involved in a wide variety of normal and pathological cellular processes, including tumorigenic transformation. Despite significant progress made towards understanding their mechanisms of action, much less is known about the regulation of expression of specific microRNAs. Recent reports have established a link between hypoxia, a key feature of the tumor microenvironment, and a group of microRNAs. Select members of this group seem to affect apoptotic signaling in a hypoxic environment and are also predicted to target genes of critical importance for tumor biology. Interestingly, most hypoxia-induced microRNAs are also overexpressed in human cancers, suggesting a role in tumorigenesis. We hereby discuss the known and predicted regulators of microRNA expression and approaches for expanding this fledgling research area.