gebhart/patrepeval huggingface dataset:
[Prolactin receptor: characterization by monoclonal antibodies and cloning of complementary DNA]. (1989)

Rat liver prolactin receptor has been partially characterized and purified to homogeneity using monoclonal antibodies. Pure receptor was digested with trypsin and amino acid sequence of receptor fragments determined. This allowed us to clone the prolactin receptor cDNA. Our approach to clone the receptor cDNA consisted of synthesizing oligonucleotides corresponding to the amino acid sequence of receptor fragments, and to screen a cDNA library. Sequencing reveals that prolactin receptor is a 291 amino acid protein, containing an extracellular domain of 210 residues, a single transmembrane segment of 24 amino acids and a cytoplasmic domain of 57 amino acids. Introduction of the prolactin receptor cDNA into various cell types demonstrates that the single protein is sufficient to bind prolactin with the same affinity and specificity reported for the prolactin receptor.
Purely numerical compensation for microscope objective phase curvature in digital holographic microscopy: influence of digital phase mask position (2006)

Introducing a microscope objective in an interferometric setup induces a phase curvature on the resulting wavefront. In digital holography, the compensation of this curvature is often done by introducing an identical curvature in the reference arm and the hologram is then processed using a plane wave in the reconstruction. This physical compensation can be avoided, and several numerical methods exist to retrieve phase contrast images in which the microscope curvature is compensated. Usually, a digital array of complex numbers is introduced in the reconstruction process to perform this curvature correction. Different corrections are discussed in terms of their influence on the reconstructed image size and location in space. The results are presented according to two different expressions of the Fresnel transform, the single Fourier transform and convolution approaches, used to propagate the reconstructed wavefront from the hologram plane to the final image plane.
A semiconductor optical amplifier with high saturation power, low noise figure and low polarization dependent gain over the C-band (2004)

A semiconductor optical amplifier (SOA) is demonstrated with greater than 14.6-dBm saturation power, less than 5.6-dB noise figure and less than 0.8-dB polarization dependent gain over the C-band (1530-1565 nm). The SOA consists of a tensile strained bulk active region and a multi-section contact layer.
Development of an Integrated Near-Field Acoustic Holography (NFAH) System on a Scanning Probe Microscopy Platform (2004)

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
Thermoelectrics: p‐Type Plastic Inorganic Thermoelectric Materials (Adv. Energy Mater. 23/2021) (2021)

In article number 2100883, Pengfei Qiu, Tian-Ran Wei, Xun Shi, and co-workers develop the first p-type plastic inorganic thermoelectric material. It can withstand up to 10% bending strain and 30% compressive strain before rupture. After optimization, the figure of merit of this p-type thermoelectric material reaches 0.95 at 800 K.
Dual Core Optical Fiber for Distributed Brillouin Fiber Sensors (2014)

A dual core optical fiber is designed and fabricated for simultaneous measurements of strain and temperature in distributed Brillouin sensors. Brillouin frequency shift difference of 120 MHz between the two cores is demonstrated.
System G Distributed Graph Database (2018)

Motivated by the need to extract knowledge and value from interconnected data, graph analytics on big data is a very active area of research in both industry and academia. To support graph analytics efficiently a large number of in memory graph libraries, graph processing systems and graph databases have emerged. Projects in each of these categories focus on particular aspects such as static versus dynamic graphs, off line versus on line processing, small versus large graphs, etc. While there has been much advance in graph processing in the past decades, there is still a need for a fast graph processing, using a cluster of machines with distributed storage. In this paper, we discuss a novel distributed graph database called System G designed for efficient graph data storage and processing on modern computing architectures. In particular we describe a single node graph database and a runtime and communication layer that allows us to compose a distributed graph database from multiple single node instances. From various industry requirements, we find that fast insertions and large volume concurrent queries are critical parts of the graph databases and we optimize our database for such features. We experimentally show the efficiency of System G for storing data and processing graph queries on state-of-the-art platforms.
Direct Measurement of the Josephson Supercurrent in an Ultrasmall Josephson Junction (2001)

We have measured the supercurrent flowing through a nonhysteretic, ultrasmall, voltage-biased Josephson junction. In contrast with experiments performed so far on hysteretic Josephson junctions, we find a supercurrent peak whose maximum I(s max) increases as the temperature T decreases. The asymptotic T = 0 value of I(s max) agrees with the junction Ambegaokar-Baratoff critical current, as predicted by theory.
Enhancing Visual Fashion Recommendations with Users in the Loop (2014)

We describe a completely automated large scale visual recommendation system for fashion. Existing approaches have primarily relied on purely computational models to solving this problem that ignore the role of users in the system. In this paper, we propose to overcome this limitation by incorporating a user-centric design of visual fashion recommendations. Specifically, we propose a technique that augments 'user preferences' in models by exploiting elasticity in fashion choices. We further design a user study on these choices and gather results from the 'wisdom of crowd' for deeper analysis. Our key insights learnt through these results suggest that fashion preferences when constrained to a particular class, contain important behavioral signals that are often ignored in recommendation design. Further, presence of such classes also reflect strong correlations to visual perception which can be utilized to provide aesthetically pleasing user experiences. Finally, we illustrate that user approval of visual fashion recommendations can be substantially improved by carefully incorporating these user-centric feedback into the system framework.
Transmetallation from CCC-NHC pincer Zr complexes in the synthesis of air-stable CCC-NHC pincer Co(<scp>iii</scp>) complexes and initial hydroboration trials (2016)

Development of CCC-NHC pincer Co complexes via transmetalation from Zr is reported. Formation of these air-stable Co(iii) complexes was achieved through use of a CoCl2 or Co(acac)3in situ or with a discrete CCC-NHC pincer Zr transmetallating agent. Preliminary activity in the hydroboration of styrene is reported. This facile methodology will further the development of CCC-NHC pincer first-row transition metal complexes.
Radius-adaptive sphere decoding via probabilistic tree pruning (2007)

In this paper, we propose a radius-adaptive sphere decoding algorithm that reduces the number of operations in sphere- constrained search while achieving performance close to ML decoding. Specifically, by adding a probabilistic noise constraint on top of sphere constraint, a more stringent necessary condition is provided, particularly at an early stage, and hence many branches that are unlikely to be selected are removed in the early stage of sphere search. From the simulation in a frequency selective channels with pruning probability epsiv = 0.03, it is shown that the computational complexity of proposed strategy reduces significantly (30~76%) over the original algorithm with negligible performance loss.
<title>Diffractive color separation for high-efficiency LCDs</title> (1997)

At the Cockpit Displays III conference, diffractive color separation was proposed as a means for improving both the performance and efficiency of liquid crystal displays. This paper discusses that approach in further detail as well as the progress made in attempting to develop the necessary technology. Specifically, progress has been made on two fronts: the development of the color separation element and the development of a low divergence backlight suitable for avionics direct view applications. The approach taken in these two developments is described as well as the current state of the development.
Metasurface Polarization Optics: Independent Phase Control of Arbitrary Orthogonal States of Polarization (2017)

We present a method allowing for the imposition of two independent and arbitrary phase profiles on any pair of orthogonal states of polarization-linear, circular, or elliptical-relying only on simple, linearly birefringent wave plate elements arranged into metasurfaces. This stands in contrast to previous designs which could only address orthogonal linear, and to a limited extent, circular polarizations. Using this approach, we demonstrate chiral holograms characterized by fully independent far fields for each circular polarization and elliptical polarization beam splitters, both in the visible. This approach significantly expands the scope of metasurface polarization optics.
Identification of the GalNAc Kinase Amino Acid Sequence (1996)

A new kinase that forms GalNAc-1-P was purified from pig kidney cytosol and identified on gels by labeling with N3-[32P]ATP (Pastuszak, I., Drake, R., and Elbein, A. D. (1996) J. Biol. Chem. 271, in press). A 50-kDa labeled protein was eluted, digested with trypsin, and the sequences of four peptides representing 49 amino acids showed 90% identity to sequence of human galactokinase reported to be on chromosome 15. To resolve this dilemma, activities and substrate specificities of galactokinase and GalNAc kinase from human and pig kidney, as well as of galactokinase from the yeast clone transfected with the cDNA from presumptive human galactokinase, were compared. The purified galactokinases phosphorylated galactose, but not GalNAc, whereas GalNAc kinase also phosphorylated galactose when this sugar was present at millimolar concentrations. Extracts of gal 1(-) yeast clone, transfected with presumptive human galactokinase cDNA, had very low galactokinase activity even when yeast were grown on galactose, but good activity with GalNAc. On the other hand, the wild type yeast phosphorylated galactose, but not GalNAc. These data indicate that the sequence reported for galactokinase on chromosome 15 is that of GalNAc kinase, which can phosphorylate galactose when this sugar is present at millimolar concentrations. This transfection thus allows the yeast mutant to grow slowly on galactose-containing media.
A galvanic isolated voltage probe for noise sources identification in EMI / EMC applications (2017)

In order to quickly identify the noise sources in power electronics converters for EMI/EMC applications, a galvanic isolated voltage probe is developed and optimized to achieve adequate measurement bandwidth and high common-mode rejection ratio (CMRR). Several structures of the voltage probes are proposed. The prototypes are built and the performances are evaluated through testing. The experimental result shows that the developed isolated voltage probe has an adequate measurement bandwidth up to 300MHz and CMRR is more than 40dB for the measurement frequency range.
Abstract 4510: RG7787 - a novel de-immunized PE based fusion protein for therapy of mesothelin-positive solid tumors (2014)

Abstract Attaching toxic payloads to antibodies has recently been established as a breakthrough in cancer therapy. Most of the currently developed antibody drug conjugate programs represent targeted chemotherapy with microtubule polymerization inhibiting drugs and hence share resistance mechanisms and side effects with classical chemotherapeutics like Taxol. Inhibition of protein synthesis by Pseudomonas Exotoxin (PE) is a more powerful mode of action that interferes with all hallmarks of cancer cells, not just with proliferation. However, its clinical use has been limited by immunogenicity as shown for SS1P, a mesothelin targeted immunotoxin. We have developed a novel de-immunized PE fusion protein (RG7787) for treatment of mesothelin-positive tumors. In order to de-immunize PE, point mutations have been introduced into domain III and the entire domain II has been deleted reducing the size of the effector moiety to approximately 24 kD. PE24 fusions with a disulfide-stabilized Fv fragment have previously been shown to be much better tolerated in rodents, but this could, at least in part, also be attributed to a much reduced serum half-life and exposure. In order to also de-immunize the targeting moiety of RG7787 and restore PK parameters similar to those of SS1P, we substituted the mouse dsFv moiety by a humanized Fab fragment. We show that RG7787 has indeed similar PK properties to SS1P in mouse and cyno. Cell viability assays show that RG7787 has similar cytotoxic potency as SS1P on different cell lines. In-vivo equipotency to SS1P in different xenograft models has been achieved at ∼3 fold higher doses indicating that tumor penetration of SS1P might be slightly better. However, RG7787 is up to tenfold better tolerated in rodents and cynomolgus monkeys, indicating that the therapeutic window is improved. RG7787 achieves potent tumor growth inhibition and even tumor regressions in several xenograft models. We also observed clearly synergistic efficacy with Taxol treatment in different tumor models making this a promising combination for clinical trials. Citation Format: Gerhard Niederfellner, Frieder Bauss, Sabine Imhof-Jung, Friederike Hesse, Sven Kronenberg, Roland Staak, Martin Lechmann, Ben Krippendorff, Wolfgang Richter, Rita Mateus, Gwendlyn Kollmorgen, Ulli Brinkmann, Masanori Onda, Ira Pastan, Klaus Bosslet. RG7787 - a novel de-immunized PE based fusion protein for therapy of mesothelin-positive solid tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4510. doi:10.1158/1538-7445.AM2014-4510
Asymmetric Electrode Configuration for Enhanced Membrane Capacitive Deionization (2014)

Long-term performance of capacitive deionization (CDI) and membrane-assisted capacitive deionization (MCDI) single cells equipped with the same pristine carbon xerogel (CX) electrodes configured as the anode and cathode was investigated. Unlike CDI, which was subject to performance degradation in a short period of time, MCDI showed performance preservation during the 50 h of operation due to its ability to mitigate charge leakage from parasitic electrochemical reactions that result in carbon oxidation. Differential capacitance measurements of the used CDI and MCDI electrodes revealed shifting of the potential of zero charge (EPZC) of the CDI anode from -0.1 to 0.4 V but only to 0.1 V for the MCDI anode. CDI and MCDI cells tested with electrodes having EPZCs at -0.1 and 0.5 V showed strongly contrasting results depending on the anode-cathode EPZC configuration. The MCDI cell configured with a 0.5 V EPZC cathode and -0.1 V EPZC anode displayed the best performance of all the tested cells, benefiting from increased counterion excess within the potential window, and the membrane was in-place to reject expelled co-ions from accessing the bulk.
Input impedance of an amplifier based on a dc superconducting quantum interference device (1984)

The measured input impedance of an amplifier involving a coil tightly coupled to a dc superconducting quantum interference device (SQUID) is found to depend on the current and flux biases of the SQUID. Variations in the input inductance arise from the reflected dynamic inductance of the SQUID, and are in reasonable agreement with the predictions of an analog simulator. Variations in the input resistance, on the other hand, arise from feedback between the output of the SQUID and the input circuit, and are in approximate agreement with the predictions of a simple model.
Subunits of luteinizing hormone-human chorionic gonodotropin receptor from bovine corpora lutea (1986)

A batch of 24 mg of luteinizing hormone-human chorionic gonadotropin (LH-hCG) receptor was isolated from bovine corpora lutea. The LH-hCG receptor showed specific binding with hCG. The receptor-hCG complex activated the regulatory Ns protein isolated from rabbit liver, which in turn stimulated adenylate cyclase to convert ATP into cAMP in vitro, attesting to the biological activity of the purified LH-hCG receptor. The LH-hCG receptor was treated with 2% sodium dodecyl sulfate (SDS) to prepare the molecular weight (Mr) 280K dimer and with 50 mM dithiothreitol (DTT) to prepare the Mr 120K monomer and subunits of Mr 85K and 38K. Oligomers of various molecular weights were recovered from gel filtration columns due to the reassociation of disulfide bonds between monomers and subunits. Hence, the receptor monomer was also dissociated into subunits of Mr 85K and 38K by reduction of -S-S-bonds with 50 mM DTT in 2% SDS and alkylation of sulfhydryl groups in the presence of 100 mM N-ethyl-maleimide. The subunits were separated by gel filtration through columns of Ultrogel AcA-44 and Sephadex G-75. The yields of the purified alkylated subunits of Mr 85K and 38K were 1.8 and 1.5 mg, respectively. Each subunit migrated as a single entity in SDS-polyacrylamide gel electrophoresis. The monomer of the receptor of Mr 120K showed specific binding with 125I-hCG, suggesting it to be the minimum molecular weight functional unit of the receptor. The Mr 85K and 38K subunits bound 125I-hCG, which could not be displaced with unlabeled hCG.(ABSTRACT TRUNCATED AT 250 WORDS)
Iridescent Chiral Nematic Mesoporous Organosilicas with Alkylene Spacers (2018)

Abstract Mesoporous organosilica films with chiral nematic structures are prepared with a bridging urea group and with alkylene bridges, where the length of the alkylene bridge varies from C 1 –C 6 . To synthesize these materials, cellulose nanocrystals (CNCs) are used as liquid crystal templates, which coassemble with the organosilica precursor to give composite materials with a chiral nematic structure of CNCs embedded within. Removal of the CNCs by acid hydrolysis results in free‐standing, mesoporous organosilica films with long‐range chiral nematic ordering of the porous network. It is found that increasing the length of the organosilica bridging groups causes phase separation between the organosilica precursors and the aqueous CNC suspension. This problem is solved through two distinct methods: combining the long alkylene‐bridged precursors with shorter precursors or by using a mixed solvent system of water and dimethylformamide during self‐assembly. The new chiral nematic mesoporous organosilica films display photonic properties, good thermal stabilities, and interconnected pore structures.
Dynamic bandwidth allocation and congestion control schemes for voice and data multiplexing in wideband packet technology (1990)

The author describes a novel bandwidth allocation method called the (T/sub 1/, T/sub 2/) scheme. It efficiently integrates packetized voice and data traffic. Voice and data packets are queued separately, and the (T/sub 1/, T/sub 2/) scheme is used to facilitate dynamic bandwidth sharing and mutual overload protection between the two queues. T/sub 1/ and T/sub 2/ are time limits for transmitting voice and data packets continually while the voice and data queues are visited alternately. The scheme guarantees bandwidths to voice and data in the proportion of their respective time slice allocations, T/sub 1/ and T/sub 2/. However, the bandwidth allocations are flexible in the sense that whenever one queue is exhausted, the transmission is immediately moved over to the other queue if it has a packet waiting to be served. The system also implements a voice block dropping scheme in which the less significant bits in voice packets are dropped during periods of congestion. The author presents results based on a simulation model which illustrate that the two schemes together provide the desired performance in terms of very good voice quality, low delay and packet loss, efficient use of transmission bandwidth, and protection in overload.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Modified Leather Processing Method for Water and Pollution Reduction in Tannery (2008)

Current practice of leather manufacture subjects the hides/skins to repeated acid and alkali treatments. Conventional process protocol results in high total dissolved solid (TDS) and chemical oxygen demand (COD) in the wastewater. Further, the process employs huge amount of water and subsequently discharges the same as wastewater. The cost for the treatment of wastewater is directly proportional to the volume of wastewater generated. In this study, the leather processing sequence has been modified for water and pollution reductions as well as better quality leather production. The modified process treats the delimed pelt with post-tanning chemicals first followed by chrome tanning salt. This is possible due to appropriate choice of charge of the hide matrix and post tanning chemicals and pH profiles of leather processing. This process logic eventually eliminates several acid and alkali treatment and washing steps that are followed in the conventional process. The percentage offer of post tanning chemicals is determined based on pelt weight to split weight relation. The leather from modified process is characterized through stratigraphic distribution of chromium, percentage oils and fats, scanning electron microscopy, softness and physical testing. The performance of the leathers is found to be on par with that of conventionally processed leathers through hand and physical evaluation. The modified process significantly reduces the usage and discharge of water by 62 and 62%, respectively. It also enjoys the reduction in COD and TS loads by 49 and 70%, respectively. Further, the process reduces the usage of chemicals by 41% by avoiding acid and alkali treatment steps. The modified process appears to be technically feasible and economically viable.
Measurement of arterial plasma oxygenation in dynamic oxygen‐enhanced MRI (2010)

Inhaled oxygen can be used as a contrast agent for magnetic resonance imaging, due to the T(1) shortening effect of the oxygen dissolved in blood and tissue water. In this study, blood T(1) was measured dynamically in 14 volunteers (seven smokers, seven never-smokers) as the inhaled gas was switched from medical air to 100% oxygen and back to medical air. These T(1) values were converted to changes in partial pressure of oxygen, which were found to be in agreement with literature values. There were differences in curve shape and curve height between the smoker and never-smoker groups, suggesting differences in lung function due to smoking-related damage. These curves could be used as an input function for modeling of oxygen uptake in tissues. The differences between groups highlight the importance of measuring such an input function for each individual rather than relying on an assumed measurement.
Zinc-indium-oxide: A high conductivity transparent conducting oxide (1995)

We report the fabrication and characterization of zinc-indium-oxide films with similar electrical conductivity and better transparency in both the visible and infrared compared with indium–tin–oxide, a widely used transparent conductor in many technological applications. Dramatically superior transmission properties in the 1–1.5 μm range in particular make zinc–indium–oxide attractive for use in infrared devices, where transparent electrodes are required. Resisitivities as low as 400 μΩ cm result from doping with small quantities of Sn; Al, Ga, and Ge are also effective dopants. Deposition on glass and quartz substrates as amorphous films by pulsed laser deposition and dc reactive sputtering is described.