gebhart/patrepeval huggingface dataset:
Antimicrobial Isothiocyanates from the Seeds of Moringa oleifera Lam. (2012)

4-(alpha-L-Rhamnosyloxy)benzyl isothiocyanate (1) and 4-(4'-O-acetyl-alpha-L-rhamnosyloxy)-benzyl isothiocyanate (2) isolated from Moringa oleifera seeds were screened for their antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, and Pseudomonas aeruginosa, and for their antifungal activities against Candida albicans, Trichophyton rubrum, and Epidermophyton floccosum using the disk diffusion method. Isothiocyanates 1 and 2 were found active at the lowest inhibitory concentration of 1 mg/ml against all Gram-positive bacteria tested (S. aureus, S. epidermidis, B. subtilis) and against the dermatophytic fungi E. floccosum and T. rubrum. Statistically significant differences were found between the mean inhibition zones (IZ) of 1 and 2 and the standard drugs, ofloxacin and clotrimazole. The minimum inhibitory concentration (MIC) values confirmed the good antimicrobial activity of 1 and 2 against S. aureus, good to moderate activity against S. epidermidis, moderate activity against B. subtilis, and weak activity against E. floccosum and T. rubrum. The in vitro bactericidal effect of 1 and 2 against the Gram-positive bacterial strains tested is suggested by MBC:MIC ratios of 2:1.
Mobile ionophores are a novel class of P‐glycoprotein inhibitors (1994)

The decrease of the intracellular concentration of drug in resistant cells compared to sensitive cells is, in most cases, correlated with the presence, in the membrane of resistant cells, of a 170‐kDa P‐glycoprotein responsible for an active efflux of the drug. In an attempt to identify mechanism(s) by which multidrug resistance can be circumvented, we have examined the cellular accumulation of 4′‐ O ‐tetrahydropyranyl‐adriamycin, alone and in conjunction with various ionophores on the one hand and with cyclosporin A on the other hand. The present study was performed using a spectrofluorometric method with which it is possible to follow continuously the uptake and release of fluorescent molecules by living cells, as the incubation of the cells with the drug proceeds. Erythroleukemia K562 cell lines were used. Using experimental conditions in which these ionophores were unable to modify either the intracellular pH, or the transmembrane potential, or to induce an intracellular ATP depletion, we have shown that mobile ionophores as well as cyclosporin inhibit the P‐glycoprotein‐mediated efflux of 4′‐ O ‐tetrahydropyranyl‐adriamycin in K562 resistant cells, whereas gramicidin, a channel‐forming ionophore, does not. The concentration that must be used to inhibit 50% of the efflux was 0.7 μM for valinomycin, 0.4 μM for nonactin, 0.2 μM for nigericin, 1.1 μM for monensin, 0.4 μM for lasalocid, 1.2 μM for calcimycin and 0.4 μM for cyclosporin. Due to the high toxicity of the ionophores, the observation that they increased 4′‐ O ‐tetrahydropyranyl‐adriamycin accumulation in the multidrug‐resistant cells is not correlated with an effect of these compounds on drug resistance. However, the correlation exists in the case of cyclosporin. From our data showing that lipophilic neutral complexes, formed between carboxylic ionophores and metal ions, as well as lipophilic cationic complexes, formed between neutral ionophores and metal ions, are both able to inhibit the P‐glycoprotein‐mediated efflux of anthracycline we can infer that the lipophilicity but not the cationic charge is an important physical property.
Abstract: How Much of the Budget will be for you? — Offshore Expenditure in the Asia-Pacific Region (2005)

Abstract The Asia-Pacific is dominated by offshore production. In 1936 the first offshore wells to be drilled in the open sea were located in Brunei. However, real growth in global offshore drilling did not occur until the 1960s, after opportunities on land had begun to decline. Well numbers then peaked in 1981 following a decade of fluctuating and rising oil prices. After a steep drop, exploration drilling levels have now stabilised, boosted by higher oil prices and the appearance of new opportunities through improved technology, but limited by the disappearance of drilling prospects in mature regions. On average just under 1000 exploratory offshore wells are drilled globally each year of which a quarter are located in this region. Around 20% of global exploratory wells are now in deepwater. In the last decade reductions in available targets in shallow waters have been counter-balanced by moves towards increasing water depths. What is the future for the Asia-Pacific; how has drilling activity and expenditure moved here and how will it move? In particular what do changes in activity mean for geoscientists engaged in exploring for and developing the region's oil and gas? Estimated offshore well expenditure in the region is shown in the below. Drilling costs vary enormously but the cost of the rig is usually between 25% and 30% of the well cost. The engineering programme makes up between 35% and 45%, depending on the total depth of the well and whether drilling problems are encountered. Support services, including transport such as boats and helicopters, make up between 20% and 30% of total costs which leaves the cost of the geological programme, depending on well objectives, at just 5% to 10% of the total. Seismic expenditure on a project, including acquisition, processing and interpretation, is roughly a third of that allocated to drilling exploratory wells. Thus it attracts around four times as much spending on an exploratory project as the geological part of a drilling programme. It is forecast that around US$22 bln will be spent over the next 5 years on all offshore drilling in the Asia-Pacific region and an additional $7bn will be spent on seismic data. Thus around $8.5 bln will be allocated to geologists and geophysicists. This paper will consider regional exploratory activity and determine what share in the global money pot geoscientists working in different parts of the region can really look forward to. Presented at: 2005 South East Asia Petroleum Exploration Society (SEAPEX) Conference, Singapore, 2005
INVESTIGATION OF JOB SATISFACTION FACTORS AFFECTING EMPLOYEES (2017)

In a globalized world where competition is rising and technology is developing rapidly, businesses have to change and improve. The transition from the industrial society to the information society leads to the developments in information technology, competition, and human rights. Thus, businesses perform a new organization structure by applications of needed to pay attention during and after of supplying employee. Businesses in the environment where technology and economy has been changing and developing have to develop management strategies. Human resources management is a strategic and detailed approach as an important resource of human management to perform its activities. Besides, it deals with human relations, the information and principles of management and employee management as a whole and with a different point of view. Since human resources are the primary source for businesses, it is essential to use human potential most effectively. The concept that supports and performs of this idea is human resources management; the main aim of it is to obtain job satisfaction by reaching the institution&#039;s goals efficiently. This research was examined the effects of employees working human resource management on job satisfaction. The data obtained from a questionnaire survey of 427 randomly selected employees from different sectors were analysed by statistical methods. Moreover, the effects of various demographic characteristics on the job satisfaction of employees were studied in the research. The effects of working environment, colleagues and managers&#039; attitudes and behaviours on job satisfaction were analysed by various statistical methods
STRATEGI PENGEMBANGAN PEMENUHAN CAPAIAN PEMBELAJARAN LULUSAN (CPL) MATA KULIAH ASAS DAN STUDIO PERANCANGAN ARSITEKTUR 1 BERBASIS KURIKULUM INTERNASIONAL KOREAN ARCHITECTURAL ACCREDITING BOARD (KAAB) (2022)

Strategi pengembangan Capaian Pembelajaran Lulusan (CPL) mata kuliah Asas dan Studio Perancangan Arsitektur 1 berbasis International Korean Architectural Accrediting Board (KAAB) merupakan kriteria acuan penilaian prestasi belajar mahasiswa dalam meningkatkan kualitas kurikulum dan perkuliahan di Jurusan Arsitektur. Metode penelitian dilakukan dengan mengembangkan model ADDIE, seperti menganalisis, merancang, mengembangkan, mengimplementasikan, dan mengevaluasi. Pengumpulan data dilakukan dengan cara observasi, angket dan wawancara kepada mahasiswa yang telah selesai mengambil mata kuliah Asas dan Studio Perancangan Arsitektur 1. Hasil yang diperoleh dari penelitian ini adalah pengembangan strategi capaian pembelajaran lulusan pada mata kuliah Asas dan Studio Perancangan Arsitektur 1 menghasilkan metode pembelajaran, penataan ulang capaian pembelajaran dan penyusunan materi buku pegangan. Capaian hasil belajar dirumuskan dengan kriteria berpikir kritis dalam arsitektur, desain, rekayasa, dan teknologi, dengan menekankan pada material dan metode bangunan.
Recognition of hand-gestures using improved local binary pattern (2011)

This paper presents an improved LBP (local binary pattern) texture descriptor, which is used to classify static hand-gesture images. The descriptor makes full use of the correlation and the differences of pixel gray value in the local regions, simple and fast coding; the descriptor is a highly discriminative texture operator, and can represent different characteristics of static hand-gesture images. Initial, we introduced the texture descriptor of improved LBP. Then, we extracted features of hand-gesture images by using improved LBP descriptor and uniform patterns encoding. At last, an Adaboost classifier performed the hand-gesture recognition task. A dataset with many hand-gestures (12 types, 600 hand-gesture images) was built, including some large pose-angle hand-gesture images. The experiment results show that the prominent performance of improved LBP descriptor; the capability of is close to LBP, superior to LAP (local angular phase). Meanwhile, the descriptor is robust to nonlinear illumination, scaling.
Preparation of Strong Antidandruff Shampoo Using Medicinal Plant Extracts: A Clinical Trial and Chronic Dandruff Treatment (2015)

Background: Nowadays more than half of the populations in the world are suffering from dandruff. Malassezia fungus is an important factor in causing dandruff as it may stimulate cytokine production by keratinocytes (epidermal cells that synthesize keratin) and inflammatory pathways. As dandruff is a hurting issue for people, a lot of efforts are being done for treatment. Many reports based on medicinal plants, seem to be more effective in curing mentioned concern. Objectives: The aim of this research was to investigate a clinical trial for dandruff therapy by Zinc L-pyrrolidone carboxylic acid (Zinc-PCA) and pirocton olamine in combination with six medicinal plant extracts. Patients and Methods: In this study, the combination of Punica granatum L, Rosmarinus officinalis L, Matricaria chamomilla L, Urtica dioica L, Mentha piperita L., and Salvia officinalis L. methanolic extracts with Pirocton Olamine and Zinc-PCA in the shampoo form were tested on 30 patients with dandruff on hair within a period of two months. Chronic dandruff of 15 patients were highly removed in the second week, 12 other patients suffering from dandruff were seen with dandruff removal after 28 days, while remaining sufferers expressed satisfaction at the end of the fifth week. Results: Based on the results, medicinal plant extracts have marvelous effects on dandruff removal with fewer side effects, though it takes long time to treat the mentioned concern.
Dynamic Prefetching of Data Tiles for Interactive Visualization (2016)

In this paper, we present ForeCache, a general-purpose tool for exploratory browsing of large datasets. ForeCache utilizes a client-server architecture, where the user interacts with a lightweight client-side interface to browse datasets, and the data to be browsed is retrieved from a DBMS running on a back-end server. We assume a detail-on-demand browsing paradigm, and optimize the back-end support for this paradigm by inserting a separate middleware layer in front of the DBMS. To improve response times, the middleware layer fetches data ahead of the user as she explores a dataset.
Retraining for a graduate program in computer science (1985)

article Free Access Share on Retraining for a graduate program in computer science Authors: Onkar P. Sharma Computer Science Dept., Moorhead State University, Moorhead, MN Computer Science Dept., Moorhead State University, Moorhead, MNView Profile , Ali Behforooz Computer Science Dept., Moorhead State University, Moorhead, MN Computer Science Dept., Moorhead State University, Moorhead, MNView Profile Authors Info & Claims ACM SIGCSE BulletinVolume 17Issue 1Mar. 1985 pp 282–288https://doi.org/10.1145/323275.323391Published:01 March 1985Publication History 0citation161DownloadsMetricsTotal Citations0Total Downloads161Last 12 Months11Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Particle Filtering and Posterior Cramér-Rao Bound for 2-D Direction of Arrival Tracking Using an Acoustic Vector Sensor (2011)

Acoustic vector sensor (AVS) measures acoustic pressure as well as particle velocity, and therefore AVS signal contains 2-D (azimuth and elevation) DOA information of an acoustic source. Existing DOA estimation techniques assume that the source is static and extensively rely on the localization methods. In this paper, a particle filtering (PF) tracking approach is developed to estimate the 2-D DOA from signals collected by an AVS. A constant velocity model is employed to model the source dynamics and the likelihood function is derived based on a maximum likelihood estimation of the source amplitude and the noise variance. The posterior Cramér-Rao bound (PCRB) is also derived to provide a lower performance bound for AVS signal based tracking problem. Since PCRB incorporates the information from the source dynamics and measurement models, it is usually lower than traditional Cramér-Rao bound which only employs measurement model information. Experiments show that the proposed PF tracking algorithm significantly outperforms Capon beamforming based localization method and is much closer to the PCRB even in a challenging environment (e.g., SNR = -10 dB).
Self-healing properties of optical Airy beams (2008)

We investigate both theoretically and experimentally the self-healing properties of accelerating Airy beams. We show that this class of waves tends to reform during propagation in spite of the severity of the imposed perturbations. In all occasions the reconstruction of these beams is interpreted through their internal transverse power flow. The robustness of these optical beams in scattering and turbulent environments is also studied experimentally. Our observations are in excellent agreement with numerical simulations.
A More Prospective Look at IGCT: Uncovering a Promising Choice for dc Grids (2018)

DC grids, including highvoltage dc (HVdc) transmissions, midvoltage dc (MVdc) distributions, and low-voltage dc (LVdc) supply systems, have elicited widespread concern and rapidly developed in recent years [1]-[6]. Voltage and power can be flexibly controlled because power electronic equipment is widely used in dc grids. Moreover, the conversion stage for energy storage and renewable energy systems in dc grids can be simplified. Such simplification can reduce cost, enhance power conversion efficiency, and improve power quality.
Space-variant optical correlator based on the fractional Fourier transform: implementation by the use of a photorefractive Bi_12GeO_2a (BGO) holographic filter (1996)

A space-variant optical correlator is proposed on the basis of the fractional Fourier transform. The optical device uses as a recording medium for the holographic filter a photorefractive Bi(12)GeO(2) (BGO) crystal. The experimental results confirm the shift-variance properties. Some limitations that arise from the volume diffraction are also considered.
Facial and vocal emotion expression of a personal computer assistant to engage, educate and motivate children (2009)

The general goal of our research is to develop a personal computer assistant that persuades children to adhere to a healthy lifestyle during daily activities at home. The assistant will be used in three different roles: as companion, educator and motivator. This study investigates whether the effectiveness of the computer assistant with an iCat robot embodiment, can be improved when it expresses emotions (tested for each of the three roles). It shows that emotion expressions can improve the effectiveness of the robot to achieve its role objectives. The improvements that we found are small, however, probably due to a ceiling effect: All subjective measures are rated very positively in the neutral condition, thus leaving little room for improvement. It also showed that the emotional speech was less intelligible, which may limit the robots' effectiveness.
NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition (2021)

Although histone deacetylase 8 (HDAC8) plays a role in glioblastoma multiforme (GBM), whether its inhibition facilitates the treatment of temozolomide (TMZ)-resistant GBM (GBM-R) remains unclear. By assessing the gene expression profiles from short hairpin RNA of HDAC8 in the new version of Connectivity Map (CLUE) and cells treated by NBM-BMX (BMX)-, an HDAC8 inhibitor, data analysis reveals that the Wnt signaling pathway and apoptosis might be the underlying mechanisms in BMX-elicited treatment. This study evaluated the efficacy of cotreatment with BMX and TMZ in GBM-R cells. We observed that cotreatment with BMX and TMZ could overcome resistance in GBM-R cells and inhibit cell viability, markedly inhibit cell proliferation, and then induce cell cycle arrest and apoptosis. In addition, the expression level of β-catenin was reversed by proteasome inhibitor via the β-catenin/ GSK3β signaling pathway to reduce the expression level of c-Myc and cyclin D1 in GBM-R cells. BMX and TMZ cotreatment also upregulated WT-p53 mediated MGMT inhibition, thereby triggering the activation of caspase-3 and eventually leading to apoptosis in GBM-R cells. Moreover, BMX and TMZ attenuated the expression of CD133, CD44, and SOX2 in GBM-R cells. In conclusion, BMX overcomes TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the β-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition. These findings indicate a promising drug combination for precision personal treating of TMZ-resistant WT-p53 GBM cells.
An Investigation of Students' Attitudes and Motivations Toward Online Learning (2007)

This study investigated students' attitudes and motivations toward online learning.
Cardiac sequelae of acute stroke. (1982)

The possibility that acute stroke produces an increase in sympathetic tone with resultant cardiac abnormalities was examined in 100 stroke patients admitted to a stroke ICU and in 50 controls found to have diagnoses other than stroke or TIA after admission to the Unit. Continuous 24 hour Holter ECG tapings were performed and serum cardiac enzymes and plasma norepinephrine concentrations were measured within 48 hours after admission. Significantly, (p less than .001) more serious arrhythmias were observed during 24 hour Holter ECG monitoring in stroke patients compared with controls and the difference remained (p less than .01) after matching for age and co-existing heart disease. Arrhythmias were more common in older stroke (p less than .001) and older control (p = .05) patients and with infarction of the cerebral hemispheres (p less than .05) as compared to brainstem lesions. Arrhythmia occurrence was independent of the presence of co-existing heart disease and the level of sympathetic activity. However, the 15 stroke patients with abnormally high CK values (mean 34.3 units) had a higher (p less than .02) mean plasma norepinephrine concentration (650.4 pg/ml) than stroke patients with normal CK (427.7 pg/ml). Acute stroke may cause cardiac arrhythmias and myocardial cell damage, the latter through stroke induced increases in sympathetic tone.
Superpixel-based 3D warping using view plus depth data from multiple viewpoints (2014)

This paper presents a method of virtual view synthesis using view plus depth data from multiple viewpoints. Intuitively, virtual view generation from those data can be easily achieved by simple 3D warping. However, 3D points reconstructed from those data are isolated, i.e. not connected with each other. Consequently, the images generated by existing methods have many holes that are very annoying due to occlusions and the limited sampling density. To tackle this problem, we propose two steps algorithm as follows. In the first step, view plus depth data from each viewpoint is 3D warped to the virtual viewpoint. In this process, we determine which neighboring pixels should be connected or kept isolated. For this determination, we use depth differences among neighboring pixels, and SLIC-based superpixel segmentation that considers both color and depth information. The pixel pairs that have small depth differences or reside in same superpixels are connected, and the polygons enclosed by the connected pixels are inpainted, which greatly reduces the holes. This warping process is performed individually for each viewpoint from which view plus depth data are provided, resulting in several images at the virtual viewpoint that are warped from different viewpoints. In the second step, we merge those warped images to obtain the final result. Thanks to the data provided from different viewpoints, the final result has less noises and holes compared to the result from single viewpoint information. Experimental results using publicly available view plus depth data are reported to validate our method.
Flash‐Aware Page Replacement Algorithm (2014)

Due to the limited main memory resource of consumer electronics equipped with NAND flash memory as storage device, an efficient page replacement algorithm called FAPRA is proposed for NAND flash memory in the light of its inherent characteristics. FAPRA introduces an efficient victim page selection scheme taking into account the benefit‐to‐cost ratio for evicting each victim page candidate and the combined recency and frequency value, as well as the erase count of the block to which each page belongs. Since the dirty victim page often contains clean data that exist in both the main memory and the NAND flash memory based storage device, FAPRA only writes the dirty data within the victim page back to the NAND flash memory based storage device in order to reduce the redundant write operations. We conduct a series of trace‐driven simulations and experimental results show that our proposed FAPRA algorithm outperforms the state‐of‐the‐art algorithms in terms of page hit ratio, the number of write operations, runtime, and the degree of wear leveling.
Microfluidic Amplification as a Tool for Massive Parallel Sequencing of the Familial Hypercholesterolemia Genes (2012)

Combining a microfluidic amplification system with massive parallel sequencing is an effective method for mutation scanning in FH patients, which can be implemented in diagnostics. For data analysis, we propose a minimum variant frequency threshold of 20% and a minimum coverage of 25-fold.