gebhart/patrepeval huggingface dataset:
Arabidopsis NF‐YB subunits LEC1 and LEC1‐LIKE activate transcription by interacting with seed‐specific ABRE‐binding factors (2009)

LEAFY COTYLEDON 1 (LEC1) plays vital roles in the regulation of seed maturation in Arabidopsis. LEC1 encodes a homolog of yeast HAP3 or mammalian NF-YB/CBF-A subunit of trimeric CCAAT binding factor (CBF). Among the nine paralogs of NF-YB in Arabidopsis, LEC1-LIKE (L1L) is most closely related to LEC1, and can complement the lec1 mutation when expressed under the control of the LEC1 promoter. Although the nature of the B3-type seed maturation regulators as transcription factors have been investigated, knowledge of the molecular action of LEC1 is limited. When co-expressed with NF-YC2 in the presence of ABA, we found that LEC1 or L1L, but not other NF-YBs, activated the promoter of CRUCIFERIN C (CRC), which encodes a seed storage protein. However, additional expression of an NF-YA subunit interfered with the activation. The LEC1/L1L-[NF-YC2] activation depended on ABA-response elements present in the promoter, which led to the finding that LEC1/L1L-[NF-YC2] can strongly activate the CRC promoter in the absence of ABA when co-expressed with a seed-specific ABA-response element (ABRE)-binding factor, bZIP67. Functional coupling of LEC1/L1L-[AtNF-YC2] and bZIP67 was also observed in the regulation of sucrose synthase 2 (SUS2). Immunoprecipitation experiments revealed that L1L and bZIP67 formed a protein complex in vivo. These results demonstrate a novel plant-specific mechanism for NF-Y subunit function that enables LEC1 and L1L to regulate a defined developmental network.
Probing the relationship between .alpha.-helix formation and calcium affinity in troponin C: proton NMR studies of calcium binding to synthetic and variant site III helix-loop-helix peptides (1991)

Three 34-residue peptides corresponding to the high-affinity calcium-binding site III and two variant sequences from the muscle protein troponin C (TnC) were synthesized by solid-phase techniques. The two variant 34-residue peptides had amino acid modifications at either the coordinating positions or both the coordinating and noncoordinating positions, which corresponded to the residues found in the low-affinity calcium-binding site II of TnC. High-field 1H NMR spectroscopy was used to monitor calcium binding to each peptide to determine the effect these amino acid substitutions had on calcium affinity. The dissociation constant of the native site III peptide (SCIII) was 3 x 10(-6) M, smaller than that of the peptide incorporating the ligands from site II (LIIL), 8 x 10(-6) M, and that with the entire site II loop (LII), 3 x 10(-3) M, which bound calcium very weakly. These calcium dissociation constants demonstrate that very minor amino acid substitutions have a significant effect on the dissociation constant and give some insight into why the dissociation constants for site III and IV in TnC are 100-fold smaller than those for sites I and II. The results suggest that the differences in coordinating ligands between sites II and III have very little effect on Ca2+ affinity and that the noncoordinating residues in the site II loop are responsible for the low affinity of site II compared to the high affinity of site III in TnC.
Case 4-1987 (1987)

Presentation of Case First admission. A 48-year-old man was admitted to the hospital because of a pleural effusion.He was well until 16 months earlier, when a routine x-ray film of the chest (Fig. 1) showed a nodule in the right lung and right pleural thickening or effusion; the patient was asymptomatic. Four months later tomographic examination of the lungs revealed that the nodule had an irregular border. He entered another hospital, where a right thoracotomy disclosed a fibrotic lesion, which was removed. He was discharged feeling well, with small bilateral pleural effusions. Three months before admission pleuritic pain developed . . .
[The terminal ileum as a co-regulator of cyclic interdigestive pancreatic secretion in man]. (1993)

Nutrients present in the ileum of humans can modulate endogenously stimulated pancreatic secretion. To determine whether cyclic interdigestive pancreatic secretion can also be influenced by nutrients in the ileum, six fasting volunteers were intubated with an oro-ileal multi-lumen tube for perfusing test and marker solutions, aspiration of duodenal contents and recording of motility. At the beginning of the interdigestive cycle, the ileum was perfused intermittently with solutions of carbohydrates, proteins or lipids in the physiological amounts observed in the ileum after a meal; saline solution was perfused as a control. After saline, protein and calcium perfusion, the expected periodic increase in chymotrypsin secretion was observed during phase II of the interdigestive cycle (p < 0.05 vs phase I). In contrast, carbohydrates and lipids inhibited the phase-II-associated increase in pancreatic secretion. These findings indicate that the ileum may be involved in the regulation of human interdigestive pancreatic secretion.
MINIMALIST: An Environment for the Synthesis, Verification and Testability of Burst-Mode Asynchronous Machines (1999)

MINIMALIST is a new extensible environment for the synthesis and verification of burst-mode asynchronous finite-state machines. MINIMALIST embodies a complete technology-independent synthesis path, with state-of-the-art exact and heuristic asynchronous synthesis algorithms, e.g.optimal state assignment (CHASM), two-level hazard-free logic minimization (HFMIN, ESPRESSO-HF, and IMPYMIN), and synthesis-for-testability. Unlike other asynchronous synthesis packages, MINIMALIST also offers many options:literal vs. product optimization, single- vs. multi-output logic minimization, using vs. not using fed-back outputs as state variables, and exploring varied code lengths during state assignment, thus allowing the designer to explore trade-offs and select the implementation style which best suits the application. MINIMALIST benchmark results demonstrate its ability to produce implementations with an average of 34% and up to 48% less area, and an average of 11% and up to 37% better performance, than the best existing package. Our synthesis-for-testability method guarantees 100% testability under both stuck-at and robust path delay fault models,requiring little or no overhead. MINIMALIST also features both command-line and graphic user interfaces, and supports extension via well-defined interfaces for adding new tools. As such, it is easily augmented to form a complete path to technology-dependent logic.
Design of Experiments and Numerical Simulation of Deteriorated High Pressure Compressor Airfoils (2016)

During the operation of a jet engine, deterioration occurs. This constantly affects the engine performance parameters like exhaust gas temperature (EGT) and thrust specific fuel consumption (TSFC). If the EGT reaches a given limit, the engine has to be overhauled during a shop visit at a MRO company (Maintenance, Repair and Overhaul). Using the example of the high pressure compressor (HPC), the airfoils get analyzed for a few geometric properties and classified as serviceable, repairable and non-repairable. The repairable airfoils go through a repair process without in detail considering the actual geometry. To improve the repair process, tailored maintenance actions are desirable. For this purpose, the aerodynamic properties of the airfoil shall be the key factor for defining the repair actions. Therefore, geometric properties with high influence on the aerodynamic performance have to be known to reduce the amount of measuring time. This paper will present a Design of Experiments (DoE) for HPC-airfoil geometry variations. Therefore, 550 different stage setups will be generated, simulated and analyzed. The database will be imported to a Kriging Method to generate a meta-model. Afterwards, the impact of the different geometric properties on the aerodynamic performance, like pressure-, work- and loss coefficients, will be analyzed by using the meta-model. The most important parameters will be determined and their impact on the flow will be explained.
<title>Statis omnidirectional stereoscopic display system</title> (1999)

A unique three camera stereoscopic omnidirectional viewing system based on the periscopic panoramic camera described in the 11/98 SPIE proceedings (AM13). The 3 panoramic cameras are equilaterally combined so each leg of the triangle approximates the human inter-ocular spacing allowing each panoramic camera to view 240 degree(s) of the panoramic scene, the most counter clockwise 120 degree(s) being the left eye field and the other 120 degree(s) segment being the right eye field. Field definition may be by green/red filtration or time discrimination of the video signal. In the first instance a 2 color spectacle is used in viewing the display or in the 2nd instance LCD goggles are used to differentiate the R/L fields. Radially scanned vidicons or re-mapped CCDs may be used. The display consists of three vertically stacked 120 degree(s) segments of the panoramic field of view with 2 fields/frame. Field A being the left eye display and Field B the right eye display.
The Interactive Video Network: An Overview of the Video Manager and the V Protocol (1995)

The AT&T Interactive Video Network (IVN) offering consists of the network elements and signaling protocol necessary to provide interactive services such as video on demand, home shopping, and interactive games, while establishing a framework for evolution to support future services. This paper introduces the network architecture being developed and the two most frequently deployed access technologies — switched digital video (SDV) and hybrid fiber-coax (HFC). It then focuses on two major AT&T Network Systems offerings that support the interactive video network — the AT&T Video Manager and the V Protocol.
In-Process Ultrasonic Inspection of Additive Manufactured Parts (2016)

This project introduces an in-situ application of ultrasonic inspection techniques to fused deposition modeling (FDM) in order to detect defects as they are produced in a 3D printed plastic part. The growth of additive manufacturing into performance critical applications has revealed the need for precise quantitative evaluation of printed parts. Ultrasonic testing has been extensively demonstrated as a means of detecting small geometric defects in materials, but has not previously been applied in-process to thermoplastic FDM. This experiment used four piezoelectric transducers bonded to the build plate of an FDM machine printing Acrylonitrile Butadiene Styrene (ABS) to ultrasonically inspect parts periodically during the printing process. Every 30 s, the partially formed model is interrogated with an ultrasonic chirp signal and the response recorded. The normalized frequency response is then compared to an experimentally determined ideal response in order to detect faults in the most recently deposited layers. This analysis is based on the hypothesis that the frequency response of the part will be substantially altered if unexpected (defective) geometries are present. Due to the complexity added by low-density internal structures, this work investigates only parts with a solid fill and simple external geometries. However, with sufficient signal processing capabilities, it is feasible to extend this technique to more complicated part shapes and low-density fill patterns, as might be expected in a manufacturing setting.
Ribonuclease L and metal-ion–independent endoribonuclease cleavage sites in host and viral RNAs (2014)

Ribonuclease L (RNase L) is a metal-ion-independent endoribonuclease associated with antiviral and antibacterial defense, cancer and lifespan. Despite the biological significance of RNase L, the RNAs cleaved by this enzyme are poorly defined. In this study, we used deep sequencing methods to reveal the frequency and location of RNase L cleavage sites within host and viral RNAs. To make cDNA libraries, we exploited the 2', 3'-cyclic phosphate at the end of RNA fragments produced by RNase L and other metal-ion-independent endoribonucleases. We optimized and validated 2', 3'-cyclic phosphate cDNA synthesis and Illumina sequencing methods using viral RNAs cleaved with purified RNase L, viral RNAs cleaved with purified RNase A and RNA from uninfected and poliovirus-infected HeLa cells. Using these methods, we identified (i) discrete regions of hepatitis C virus and poliovirus RNA genomes that were profoundly susceptible to RNase L and other single-strand specific endoribonucleases, (ii) RNase L-dependent and RNase L-independent cleavage sites within ribosomal RNAs (rRNAs) and (iii) 2', 3'-cyclic phosphates at the ends of 5S rRNA and U6 snRNA. Monitoring the frequency and location of metal-ion-independent endoribonuclease cleavage sites within host and viral RNAs reveals, in part, how these enzymes contribute to health and disease.
Trajectory generation for camless internal combustion engine valve control (2004)

Camless internal combustion engines offer major improvements over traditional engines in terms of efficiency, maximum torque and power, pollutant emissions. Electromechanical valve actuators are very promising in this context, but still present significant control problems. Low valve seating velocity, small transition time for valve opening and closing, unavailability of position sensor are the main objectives to be considered in the design of the valve control system. Actuator physical limitations strongly influence the feasible trajectory when low valve seating velocity is required, thus affecting valve transition time. One key point for the control is the design of the reference trajectory to be tracked by the closed loop controller. In this paper, the trajectory design is addressed, solving an optimization parametric problem that explicitly considers the physical constraints and the trade-off between fast dynamic performance and system robustness.
Network impacts of privacy and authentication protocols for PCS (2002)

This paper describes the message flow due to authentication, voice privacy, and signaling message encryption of two schemes that are expected to be incorporated in the EIA/TIA's cellular industry Interim Standard IS 41 Revision C. We compare the two schemes with the use of a simple mobility model for users and study their impact on the traffic to network databases. Defining user mobility rate as the number of registrations per hour per user, we show that as the user mobility rate increases from roughly 0.5 to 15, the effectiveness of one of the schemes (the one that shares the shared secret data or SSD with the visited system) as compared to the other (the one that does not share it with the visited system) varies from about 66% improvement to about 30% degradation, clearly implying that the mobility characteristics of the user population dictate the choice of the authentication scheme.
Development of high performance solid polymer electrolyte water electrolyzer in WE-NET (2002)

Fuji Electric Corporate Research and Development, Ltd. has been developing technologies for high performance solid polymer electrolyte water electrolyzers. In term of technical features, Fuji Electric's technological approach call for membrane-electrode assemblies to be formed by a hot-press method. In the development activities, diverse types of current collectors were test-produced by changing coating materials and methods and various types of 50 cm/sup 2/ membrane-electrode assemblies were fabricated by changing anode catalyst species, membrane species and catalyst loading amount. Based on the results of the performance evaluations of those samples, the authors have obtained a test-produced high performance electrolyzer with platinum-plated titanium fiber plate, gold-plated stainless steel fiber plate and a membrane-electrode assembly composed of iridium dioxide, platinum black and perfluorocarbon sulfonic acid membrane, which registered 1.53 V of cell voltage and 99.2% of current efficiency and 95.8% of energy efficiency for a current density of 1A/cm/sup 2/ at a temperature of 80/spl deg/C, under atmospheric pressure.
Deployable antennas for CubeSat and space communications (2012)

In this paper we propose two UHF antenna concepts to be deployed on a CubeSat platform. Both antennas display logarithmic periodicity in their structure. The first antenna proposed is the conical log spiral antenna while the second is the log periodic crossed dipole antenna array. The design of these antennas as well as their deployment mechanisms are also discussed and presented.
Comparison of the MHC I Immunopeptidome Repertoire of B‐Cell Lymphoblasts Using Two Isolation Methods (2018)

Significant technological advances in both affinity chromatography and mass spectrometry have facilitated the identification of peptides associated with the major histocompatibility complex class I (MHC I) molecules, and enabled a greater understanding of the dynamic nature of the immunopeptidome of normal and neoplastic cells. While the isolation of MHC I-associated peptides (MIPs) typically used mild acid elution (MAE) or immunoprecipitation (IP), limited information currently exists regarding their respective analytical merits. Here, a comparison of these approaches for the isolation of two different B-cell lymphoblast cell models is presented, and it is reported on the recovery, reproducibility, scalability, and complementarity of identification from each method. Both approaches yielded reproducible datasets for peptide extracts obtained from 2 to 100 million cells, with 2016 to 5093 MIPs, respectively. The IP typically provides up to 6.4-fold increase in MIPs compared to the MAE. The comprehensiveness of these immunopeptidome analyses is extended using personalized genomic database of B-cell lymphoblasts, and it is discovered that 0.4% of their respective MIP repertoire harbored nonsynonymous single nucleotide variations (also known as minor histocompatibility antigens, MiHAs).
Comprehensive analysis of drive performance when using a dc link choke vs. an input line reactor (2015)

Differences between a dc link choke versus an input line reactor in an adjustable speed drive can be examined based on several different aspects of drive performance, including harmonic mitigation, dc bus voltage drop, operation during voltage imbalance, cost of the reactor, electric surge protection, and operation for different types of system grounding. Of these performance aspects, harmonic mitigation, bus voltage drop, operation during voltage imbalance, and cost are well understood in prior art. In this paper, the effectiveness of dc link chokes and input line reactors for both surge protection and common mode (CM) issues on different types of system grounding is examined. The harmonic performance of each reactor type as well as the relative dc bus voltage drop are also reviewed for completeness.
Controlling and monitoring Singapore's underground grid (1999)

Designed and operated as a totally underground system for environmental and aesthetic reasons, underground cables are exclusively used in the Singapore transmission network at voltages up to 400 kV. Fully metal-clad sulphur hexaflouride (SF/sub 6/) gas insulated switchgear (GIS) is used at all transmission levels to circumvent land scarcity in the siting of substations. To maintain and ensure reliability and availability of transmission facilities, technologically advanced systems for protection, control, supervision, and online diagnostics are employed. These are: computer-based integrated substation protection and control monitoring systems, partial discharge measurement systems, and distributed temperature sensing systems. These systems are discussed in this paper.
Bringing Semantics in Word Image Retrieval (2013)

Performance of the recognition free approaches for document retrieval, heavily depends on the exact or approximate matching of images (in some feature space) to retrieve documents containing the same word. However, the harder problem in information retrieval is to effectively bring semantics into the retrieval pipeline. This is further challenging when the matching is based on visual features. In this work, we investigate this problem, and suggest a solution by directly transferring the semantics from the textual domain. Our retrieval framework uses (i) the language resources like Word Net and (ii) an annotated corpus of document images, to retrieve semantically relevant words from a large word image database. We demonstrate the method on two languages - English and Hindi, and quantitatively evaluate the performance on annotated word image databases of more than a Million images.
Novel Approach to the Synthesis of 6‐Substituted 5,6‐Dihydro‐2(2<i>H</i>)‐pyranones (1981)

Abstract Easily accessible dihydropyrans 9, 10, 12 and 19 are precursors for the synthesis of 6‐substituted 5,6‐dihydro‐2 (2 H )‐pyranones and 6‐substituted tetrahydro‐2‐pyranones. Syntheses of massoia lactone ( 3 ), argentilactone ( 5 ), tuberolactone ( 4 ) and jasmine lactone ( 2 ) from acrolein ( 6 ), acrolein dimer ( 7 ) or glutaraldehyde ( 16 ) are described.
Effective channel coding for DCT watermarks (2002)

We describe effective channel coding strategies which can be used in conjunction with linear programming optimization techniques for the embedding of robust perceptually adaptive DCT domain watermarks. The main contributions lie in the proposal of a coding strategy based on the magnitude of a DCT coefficient, the use of turbo codes for effective error correction, and finally the incorporation of JPEG quantization tables at embedding.
A Three-step Proteolytic Cascade Mediates the Activation of the Peptidoglycan-induced Toll Pathway in an Insect (2008)

The recognition of lysine-type peptidoglycans (PG) by the PG recognition complex has been suggested to cause activation of the serine protease cascade leading to the processing of Spätzle and subsequent activation of the Toll signaling pathway. So far, two serine proteases involved in the lysine-type PG Toll signaling pathway have been identified. One is a modular serine protease functioning as an initial enzyme to be recruited into the lysine-type PG recognition complex. The other is the Drosophila Spätzle processing enzyme (SPE), a terminal enzyme that converts Spätzle pro-protein to its processed form capable of binding to the Toll receptor. However, it remains unclear how the initial PG recognition signal is transferred to Spätzle resulting in Toll pathway activation. Also, the biochemical characteristics and mechanism of action of a serine protease linking the modular serine protease and SPE have not been investigated. Here, we purified and cloned a novel upstream serine protease of SPE that we named SAE, SPE-activating enzyme, from the hemolymph of a large beetle, Tenebrio molitor larvae. This enzyme was activated by Tenebrio modular serine protease and in turn activated the Tenebrio SPE. The biochemical ordered functions of these three serine proteases were determined in vitro, suggesting that the activation of a three-step proteolytic cascade is necessary and sufficient for lysine-type PG recognition signaling. The processed Spätzle by this cascade induced antibacterial activity in vivo. These results demonstrate that the three-step proteolytic cascade linking the PG recognition complex and Spätzle processing is essential for the PG-dependent Toll signaling pathway.