gebhart/patrepeval huggingface dataset:
Regional Chemotherapy of the Lung: Transpulmonary Chemoembolization in Malignant Lung Tumors (2013)

Standard treatment options in patients with lung cancer and pulmonary metastases are surgery, radiotherapy, chemotherapy, and immunotherapy. For reducing clinical complications of surgery and achieving a better local response, transpulmonary chemoembolization of the lungs is a possible interventional technique in which anticancer drugs are administered directly into a tumor through its feeding vessels followed by occlusive agents that are injected through the delivery catheter for blocking the vessel. This allows a longer contact period in the tumor with a higher cytostatic drug concentration. The technique is safe and results present promising local response rates, but the influence on survival is still questionable. This article describes the current role of intravascular therapies in the treatment of pulmonary malignancies.
Demand Forecasting for Server Manufacturing Using Neural Networks (2014)

Within the global market, server manufacturers face the challenges associated with competition, customer service costs, and a large variety of components that are expensive and carry a high inventory cost. Additional challenges arise from the extensive testing of components required for quality assurance, the complex product configurations, and the potential long lead time from suppliers. The unique nature of server manufacturing makes an accurate forecasting model imperative to developing a quick response to face these challenges. Currently at the operational level, demand forecasting in server systems is reliant on a discrete event simulation approach. This model relies on the demand data obtained from the planning department. Under certain conditions the model may be able to forecast inventory costs with up to an 80% accuracy level. This research proposes a neural network approach to forecasting the demands of server systems. Trends and seasonality patterns in historical demand data are extracted and modeled. Then a design of experiment is used to create the appropriate parameters for the network. The developed forecasting model is trained, tested, and validated using 52 weeks of demand data. The neural-network-based model can predict future demand with an average of 89% and 84% accuracy level for server models 1 and 2, respectively.
4D Visualization of Dynamic Events From Unconstrained Multi-View Videos (2020)

We present a data-driven approach for 4D space-time visualization of dynamic events from videos captured by hand-held multiple cameras. Key to our approach is the use of self-supervised neural networks specific to the scene to compose static and dynamic aspects of an event. Though captured from discrete viewpoints, this model enables us to move around the space-time of the event continuously. This model allows us to create virtual cameras that facilitate: (1) freezing the time and exploring views; (2) freezing a view and moving through time; and (3) simultaneously changing both time and view. We can also edit the videos and reveal occluded objects for a given view if it is visible in any of the other views. We validate our approach on challenging in-the-wild events captured using up to 15 mobile cameras.
Sensitivity of Streptococcus Bovis to Various Antibiotics (1979)

Ruminal lactic acidosis is thought to be initiated by a proliferation of Streptococcus bovis following the overeating of readily fermentable carbohydrate. The purpose of this work was to identify those antibiotics that are most active against this microbe for later evaluation in vivo as a prophylactic treatment for lactic acidosis. Studies were conducted to develop a sensitive microbiological assay for activity against Streptococcus bovis and to use this assay to evaluate available antibiotics. A procedure for a large capacity disc assay is described. The assay produces a linear relationship between the log of the concentration of the antibiotic and the diameter of the zone of inihibition squared. The assay is sensitive to the reference antibiotic, thiopeptin, at .3 μg/ml and provides an assay range from .3 to 5.0 μg/ml. Of the antibiotics evaluated, the penicillins, including penicillin G and ampicillin, and the sulfur-containing peptide antibiotics, including thiopeptin, sulfo-mycin, thiostrepton, siomycin, sporangiomycin and taitomycin, were the most active. Although the penicillins were the most active in vitro, previous work by others has demonstrated that the rumen contains an active penicillinase which destroys penicillin and renders it relatively ineffective in vivo. The sulfur-containing peptide antibiotics, especially thiopeptin, sulfomycin and thiostrepton, are highly active against Streptococcus bovis and appear to be excellent candidates for the control of ruminal Streptococcus bovis.
Dissolution (2017)

Research Article| August 01 2017 Dissolution Ember Johnson Ember Johnson Ember Johnson lives and writes in Center City, Minnesota. She was a winner of the 2013–14 Loft Mentor Series in nonfiction, and previous work has appeared in Georgetown Review. She is currently working on a collection of essays that describe the experience of the Iraq War as told by the spouse left behind. Recently she began pursuing an MFA degree at the University of Minnesota. Search for other works by this author on: This Site Google Fourth Genre: Explorations in Nonfiction (2017) 19 (2): 15–20. https://doi.org/10.14321/fourthgenre.19.2.0015 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Ember Johnson; Dissolution. Fourth Genre: Explorations in Nonfiction 1 August 2017; 19 (2): 15–20. doi: https://doi.org/10.14321/fourthgenre.19.2.0015 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveMichigan State University PressFourth Genre: Explorations in Nonfiction Search Advanced Search The text of this article is only available as a PDF. © 2017 Michigan State University Press2017 Article PDF first page preview Close Modal You do not currently have access to this content.
Urea-to-Albumin Ratio and In-Hospital Mortality in Severe Pneumonia Patients (2021)

Higher UAR levels at the commencement of admission to ICU may be independently associated with increased in-hospital mortality in SP patients.
Synthesis of Pullulan by Acetone-dried Cells and Cell-free Enzyme from Pullularia pullulans, and the Participation of Lipid Intermediate (1973)

It was demonstrated that the polysaccharide, pullulan, was synthesized from sucrose by acetone-dried cells of Pullularia pullulans or from UDPG by cell-free enzyme preparations prepared from the organism. The pullulan formed was estimated by precipitation with ethanol, and determining maltotriose produced after treating the precipitate with Aerobacter isoamylase (pullulanase). Acetone cells (5 g) shaken with 200 ml of 10% sucrose produced over 250 mg of pullulan per 100 ml after 90 hr at 30°C and pH 6.0. Cell-free enzyme produced pullulan from UDPG in the presence of ATP. ATP was essential for the biosynthesis, and ADPG could not replace for UDPG. In addition, it was observed that a lipid containing glucose residue was formed during, the reaction. The nature of this glucolipid was examined, and possible participation of a lipid intermediate was assumed in the pullulan biosynthesis.
Characterizing the tissue dielectric constant of skin basal cell cancer lesions (2018)

(1) Main results do not support using TDC measurements to differentiate in vivo skin cancer lesions from non-cancerous lesions. (2) TDC values strongly suggest reduced water content of both cancerous and non-cancerous lesions. (3) Lesion TDC measurements provide reference values for future studies.
Multi‐omic profiling of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production (2015)

Chinese hamster ovary (CHO) cells are the preferred production host for many therapeutic proteins. The production of heterologous proteins in CHO cells imposes a burden on the host cell metabolism and impact cellular physiology on a global scale. In this work, a multi-omics approach was applied to study the production of erythropoietin (EPO) in a panel of CHO-K1 cells under growth-limited and unlimited conditions in batch and chemostat cultures. Physiological characterization of the EPO-producing cells included global transcriptome analysis, targeted metabolome analysis, including intracellular pools of glycolytic intermediates, NAD(P)H/NAD(P)(+) , adenine nucleotide phosphates (ANP), and extracellular concentrations of sugars, organic acids, and amino acids. Potential impact of EPO expression on the protein secretory pathway was assessed at multiple stages using quantitative PCR (qPCR), reverse transcription PCR (qRT-PCR), Western blots (WB), and global gene expression analysis to assess EPO gene copy numbers, EPO gene expression, intracellular EPO retention, and differentially expressed genes functionally related to secretory protein processing, respectively. We found no evidence supporting the existence of production bottlenecks in energy metabolism (i.e., glycolytic metabolites, NAD(P)H/NAD(P)(+) and ANPs) in batch culture or in the secretory protein production pathway (i.e., gene dosage, transcription and post-translational processing of EPO) in chemostat culture at specific productivities up to 5 pg/cell/day. Time-course analysis of high- and low-producing clones in chemostat culture revealed rapid adaptation of transcription levels of amino acid catabolic genes in favor of EPO production within nine generations. Interestingly, the adaptation was followed by an increase in specific EPO productivity.
Effect of Thrombolytic Therapy on Platelet Expression and Plasma Concentration of PECAM-1 (CD31) in Patients With Acute Myocardial Infarction (1999)

Animal studies have shown that the administration of antibodies against platelet/endothelial cell adhesion molecule-1 (PECAM-1) before reperfusion can reduce infarct size. The purpose of the present study was to define the effects of thrombolytic therapy in acute myocardial infarction (AMI) patients on the platelet expression and plasma concentrations of PECAM-1 at prespecified time points after attempted reperfusion. The plasma concentration and platelet expression of PECAM-1 were determined in 23 AMI patients enrolled in the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO-III) trial before thrombolysis and at 3, 6, 12, and 24 hours thereafter and compared with 22 healthy controls. At baseline, PECAM-1 was expressed significantly more on the platelet surface in the AMI patients than in controls (P=0.027) while soluble PECAM-1 plasma levels were almost identical between groups. There were no significant diurnal variations in both plasma and platelet PECAM-1 levels in controls. A significant decrease in platelet PECAM-1 expression was observed 3 hours after thrombolysis (P=0.03) compared with baseline, followed by a significant increase (P=0.004) in fluorescence intensity later at 24 hours after thrombolysis. Conversely, a significant increase in soluble PECAM-1 was observed 3 hours after thrombolysis (P=0.02), followed by a significant decrease later at 24 hours after attempted reperfusion (P=0.03). The expression of platelet-bound PECAM-1 is increased in AMI patients. Discordantly directed changes in soluble and platelet PECAM-1 after the first 24 hours after thrombolytic therapy may represent redistribution of the whole PECAM-1 pool. Further investigation of the possible role of PECAM-1 and the relationship between its soluble and platelet fractions in AMI are warranted.
Design and Development of an Image Processing Based Adaptive Traffic Control System with GSM Interface (2009)

With the increasing number of vehicles on the road, it has become difficult to properly control the flow of traffic especially in large cities like Lahore. The proposed system uses a digital camera mounted on a stepper motor to sense the traffic on the road. The decision to open the lane is done after monitoring the traffic load. The heavily loaded side is turned on for a longer time. Thus the system is intelligent because it is not using the fixed time frame. The system is also integrated with GSM, thus the signals can also be controlled with the help of mobile in case of an emergency. MATLAB <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> programming environment has been used in simulating and developing the system.
Physiology, pathophysiology, and anthropology/epidemiology of human earcanal secretions. (1997)

Two types of glands are found in the outer third of the human earcanal: sebaceous glands that produce sebum and modified apocrine glands that produce apocrine sweat. Together, these substances make up cerumen, which serves to clean, lubricate, and, to some extent, protect the earcanal from bacteria and fungus. Excessive/impacted cerumen can cause tinnitus, vertigo, itching, pain, external otitis, and hearing loss. Two populations are known to have a high incidence of excessive/impacted cerumen: individuals with mental retardation and the elderly. Anthropologists have used cerumen type to tract human migratory patterns and epidemiologists have related cerumen type to breast cancer.
The Investigation of the Waveguiding Properties of Silk Fibroin from the Visible to Near-Infrared Spectrum (2018)

Silk fibroin protein has been reinvented as a new optical material for biophotonic applications because of its optical transparency, biocompatibility, and easy fabrication process. It is used in various silk-based optical devices, which makes it desirable to investigate the optical properties of silk from diverse perspectives. This paper presents our investigation of the optical properties of silk fibroin, extracted from <i>Bombyx mori</i> cocoons. We have measured transmission spectra from the visible to near-infrared region and investigated waveguiding properties by the prism-coupling technique for five wavelengths (473.0, 632.8, 964.0, 1311, and 1552 nm). From the measurements, we determined the values of refractive indices. The measurements also proved waveguiding properties for all of the wavelengths. Optical scattering losses were measured by the fiber probe technique at 632.8 nm and were estimated to be 0.22 dB·cm<sup>-1</sup>.
Technical Note: SpekPy v2.0—a software toolkit for modeling x‐ray tube spectra (2021)

SpekPy v2 can reliably predict on- and off-axis spectra for tungsten and molybdenum targets. SpekPy's open-source MIT license allows users the freedom to incorporate this powerful toolkit into their own projects.
Evaluation of multiple frequency bioelectrical impedance and Cole-Cole analysis for the assessment of body water volumes in healthy humans. (1996)

This study has undertaken the most extensive analysis to date of relationships between TBW (and ECW) and individual impedances obtained at different frequencies ( > 400 frequencies), and has shown marginal advantages of using one frequency over another, even if values predicted from theoretical bioimpedance models are used in the estimations. However in situations where there are disturbances of fluid distribution, values predicted from the Cole-Cole analysis of swept frequency bioimpedance measurements could prove to be more useful.
A systematic review of the next‐day effects of heavy alcohol consumption on cognitive performance (2018)

The research literature suggests that alcohol hangovers may involve impaired cognitive functions and performance of everyday tasks such as driving.
Histone Methyltransferases as Therapeutic Targets for Kidney Diseases (2019)

Emerging evidence has demonstrated that epigenetic regulation plays a vital role in gene expression under normal and pathological conditions. Alterations in the expression and activation of histone methyltransferases (HMTs) have been reported in preclinical models of multiple kidney diseases, including acute kidney injury, chronic kidney disease, diabetic nephropathy, polycystic kidney disease, and renal cell carcinoma. Pharmacological inhibition of these enzymes has shown promise in preclinical models of those renal diseases. In this review, we summarize recent knowledge regarding expression and activation of various HMTs and their functional roles in some kidney diseases. The preclinical activity of currently available HMT inhibitors and the mechanisms of their actions are highlighted.
An InGaAs-GaAs strained layer single quantum-well ring laser with a reactive ion-etched tetragonal cavity (1995)

An InGaAs-GaAs-AlGaAs strained layer quantum-well ring laser with a tetragonal cavity consisting of one symmetric and one asymmetric corner reflector both fabricated by reactive ion etching is described. Two beams emit from one facet with inclined angles predicted by Snell's Law. An increase of the threshold with incident angle is observed. Longitudinal mode behavior and L-I characteristics, which indicate the presence of strong competition between clockwise and counter-clockwise traveling waves, are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reputation Based Access Point Selection in 802.11 Network (2008)

In an 802.11 wireless network with multiple access points (APs), for a commercial user, a prime concern is how to discover the desired AP since the AP providers maybe selfish and owned by different organization. This paper presents a generic reputation based framework for AP selection for this case. An M/M/1 queuing model is introduced to get a quantitative insight into the performance of wireless AP. Analytical expression for the transmission attempt probability of packet in an 802.11 network is derived and used to calculate the reputation value. The model also shows how the reputation values can be updated based on the result of service to eliminate the impact of misbehavior AP providers. Finally results are validated via simulation with statistical analysis.
Metabolomics analysis for hydroxy-L-proline-induced calcium oxalate nephrolithiasis in rats based on ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (2016)

About 80% of kidney stones are composed of calcium oxalate (CaOx) with variable amounts of calcium phosphate, and hyperoxaluria is considered as an important factor of CaOx nephrolithiasis. However, the underlying metabolic mechanisms of CaOx nephrolithiasis remain undefined. In this study, we successfully developed a rat model with hydroxy-L-proline (HLP) -induced CaOx nephrolithiasis. Rats were continuously orally administrated with HLP for 28 days. Urine and blood samples were collected from the rats treated with or without HLP at four different time points. UPLC-Q-TOF/MS was applied to profile the abundances of metabolites. To obtain more comprehensive analysis of metabolic profiling spectrum, combination of RP-LC and HILIC were applied. We identify 42 significant differential metabolites in the urine, and 13 significant differential metabolites in the blood. Pathway analysis revealed that the pathways involved in amino acid metabolism, taurine metabolism, bile acid synthesis, energy metabolism, TCA cycle, purine metabolism, vitamin metabolism, nicotinic acid and nicotinamide metabolism have been modulated by HLP treatment. This study suggested that a number of metabolic pathways are dysfunctional in the HLP induced crystal kidney injury, and further studies on those pathways are warranted to better understand the metabolic mechanism of CaOx nephrolithiasis.
Some acoustical properties of the otic bones of a fin whale (1996)

The otic bones in this report are the tympanic bulla, the periotic, and the three ossicles (malleus, incus, and stapes) of an adult fin whale (Balaenoptera physalus). The purpose was to determine if the periotic was denser than the other otic bones. It was found in one male adult fin whale that the density of all the otic bones is approximately the same, 2.50 kg/m3 with a maximum of 2.58. The lowest density was observed in the stapes (2.36). The sonic velocity seems to vary as the density but there also seems to be a structural effect. The maximum sonic velocity was 4.89 km/s in the malleus. The specific acoustic impedance was as high as 12.5 megarayles in the periotic. These values compare with those for human femur of 1.95 for the density, 3.73 for the sonic velocity, and 7.33 for the specific acoustic impedance. The ossicles weigh as much as 200 times as much as human ossicles. The density of whale ossicles are about ten percent greater than human ossicles. The mechanical natural frequency of the whale ossicles must be very low. The approximate uniformity of the properties of this whale's otic bones may be characteristic of the middle ear. The density of the otic bones of land mammals is less than for whales. The density of the horse petrosal (2.29 g/cc) is essentially the same as the density of adult human ossicles (2.23-2.27 g/cc). The high density of the otic bones for all mammals suggests it may be related to hearing acuity perhaps by increasing the specific acoustic impedance, which increases the acoustic contrast with the other body tissues.
Understanding the Impact of Precision Quantization on the Accuracy and Energy of Neural Networks (2016)

Deep neural networks are gaining in popularity as they are used to generate state-of-the-art results for a variety of computer vision and machine learning applications. At the same time, these networks have grown in depth and complexity in order to solve harder problems. Given the limitations in power budgets dedicated to these networks, the importance of low-power, low-memory solutions has been stressed in recent years. While a large number of dedicated hardware using different precisions has recently been proposed, there exists no comprehensive study of different bit precisions and arithmetic in both inputs and network parameters. In this work, we address this issue and perform a study of different bit-precisions in neural networks (from floating-point to fixed-point, powers of two, and binary). In our evaluation, we consider and analyze the effect of precision scaling on both network accuracy and hardware metrics including memory footprint, power and energy consumption, and design area. We also investigate training-time methodologies to compensate for the reduction in accuracy due to limited bit precision and demonstrate that in most cases, precision scaling can deliver significant benefits in design metrics at the cost of very modest decreases in network accuracy. In addition, we propose that a small portion of the benefits achieved when using lower precisions can be forfeited to increase the network size and therefore the accuracy. We evaluate our experiments, using three well-recognized networks and datasets to show its generality. We investigate the trade-offs and highlight the benefits of using lower precisions in terms of energy and memory footprint.