gebhart/patrepeval huggingface dataset:
Profile detection in multiuser digital subscriber line systems (2002)

Multiuser transmission methods for digital subscriber line (DSL) systems have become of interest with the potential for increased data rate and loop reach. These methods often assume that the set of crosstalk interferers, called the crosstalk profile, and their associated channel responses are known. For DSL systems, the interferers are often uncoordinated, so that in a dynamic environment where DSL transmitters can energize and deenergize, the crosstalk profile cannot be transmitted to the user of interest. While the crosstalk channel estimation problem in a dynamic environment can be intractable for general transmission systems, channel and crosstalk analysis can make use of the specific DSL environment. Namely, the physical channels in a DSL system do not change rapidly, and hence estimates of the crosstalk channel can be saved for future reference. For this reason, we introduce the concept of a channel profile. We develop several algorithms to detect the crosstalk profile and investigate the asymptotic behavior of the new algorithms. Simulations show that for typical crosstalk interference scenarios, the observation time to determine the correct crosstalk profile at probability of error less than 10/sup -3/ can be less than 2 ms.
Pyrrole‐Imidazole Polyamides: Automated Solid‐Phase Synthesis (2015)

In this unit, the fully automated solid-phase synthetic strategy of hairpin Py-Im polyamides is described using triphosgene (BTC) as a coupling agent. This automated methodology is compatible with all the typical building blocks, enabling the facile synthesis of polyamide libraries in 9% to 20% yield in 3 days.
Multifunctional logic circuit using ambipolar carbon nanotube transistor (2009)

We demonstrate doping-free and adaptive inverter to verify that the single ambipolar SWCNT transistors can be utilized both p- and n-type. Furthermore, we fabricate an adaptive logic circuit that can reveal multifunctions such as NOR and NAND gate using four ambipolar transistors. This new approach is innovative in several aspects, for instance, in improving integration density, simplicity without intentional doping, and its multifunctionality and ensures multidisciplinary interests in materials, physics, mechanics, and electronics areas.
Abstract 750: Modular coiled-coil masking domains for tumor-specific antibody activation (2018)

Abstract The power of monoclonal antibody therapeutics arises from their remarkable selectivity for a particular antigen. However, antibody therapies can still be limited by serious side effects that result from target-mediated toxicity when the antigen is also expressed on non-diseased tissue. An emerging concept in the field of therapeutic antibodies is to restrict antibody binding in healthy tissues while empowering the antibody at sites of disease. This has previously been accomplished by fusing masking groups to the antibody through cleavable sequences that can be activated upon hydrolysis by disease-associated proteases. Here, we present a novel approach to mask antibodies utilizing a variety of leucine zipper coiled-coil peptides fused to the N-termini of antibody heavy and light chains. An optimized heterodimeric coiled-coil masking domain was identified that significantly impaired the binding of multiple antibodies to their cognate receptors with no antibody-specific optimization required. Protease-cleavable linkers were introduced between the coiled-coil peptides and antibody termini, and protease-catalyzed removal of the coiled-coil domains restored antibody binding affinity to that of the unmasked parent antibody. The coiled-coil mask did not impair production of antibody-drug conjugates (ADCs) of varying drug-to-antibody ratios, and masked antibodies and ADCs had similar stability and pharmacokinetic profiles to unmasked counterparts. However, coiled-coil masked ADCs and antibodies displayed decreased functional activity in biological assays, commensurate with the decrease in affinity afforded by masking, and this activity could be restored upon cleavage of the mask. Lastly, coiled-coil masked antibodies and ADCs had been tested in vivo and had demonstrated improved safety benefits as well as equivalent antitumor activity compared to the unmasked counterparts. Coiled-coil masked antibodies represent an advance in the field of antibody pro-drugging, as this modular domain can be rapidly applied to an array of therapeutic antibodies and ADCs. Citation Format: Vivian H. Trang, Xinqun Zhang, Melissa M. Dominguez, Weiping Zeng, Julia H. Cochran, Ivan J. Stone, Peter D. Senter, Matthew R. Levengood. Modular coiled-coil masking domains for tumor-specific antibody activation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 750.
<title>Image paradigm for semiconductor defect data reduction</title> (1996)

Automation tools for semiconductor defect data analysis are becoming necessary as device density and wafer sizes continue to increase. These tools are needed to efficiently and robustly process the increasing amounts of data to quickly characterize manufacturing processes and accelerate yield learning. An image-based method is presented for analyzing process 'signatures' from defect data distributions. This paper describes the statistical and morphological image processing methods used to achieve an automated segmentation of signature events into high-level process-oriented categories. Applications are presented for enhanced statistical process control, automatic process characterization, and intelligent subsampling of event distributions for off-line, high-resolution defect review.
Aligned Macroscopic Domains of Optoelectronic Nanostructures Prepared via Shear‐Flow Assembly of Peptide Hydrogels (2011)

A facile technique is reported to prepare globally aligned arrays of self-assembled peptide nanostructures within macroscopic hydrogels starting from a solution of peptide molecules with embedded π-conjugated oligomers. The alignment of the π-stacked conduits within these macrostructures is verified with polarized optical microscopy and leads to anisotropic photophysical and electrical properties.
Composite approach for layered hybrid perovskites: band alignment, quantum and dielectric confinements (2018)

This work was granted access to the HPC resources of [TGCC/CINES/IDRIS] under the allocation 2017-A0010907682 made by GENCI.
Switched Capacitor dc-dc converter based maximum power point tracking of a PV source for nano satellite application (2010)

The power yield of a PV array depends on solar radiation and temperature. Maximum power point (MPP) tracking techniques are employed to maximize the output power of a PV source. The solar panel is the primary power source of a nano satellite. To optimize the panel design, an electrical MPP tracking scheme is very vital to extract maximum power from the panel at all instances. MPP tracking schemes known thus far employ conventional DC-DC power converters using inductors which hinder miniaturization. This paper demonstrates the use of a buck type Switched Capacitor (SC) dc-dc converter for MPP tracking for an 8Kg remote sensing nano satellite. Since SC converters do not use inductors, they have a large power density and are amenable to miniaturization. A novel method of MPP tracking is presented which involves the measurement of the panel voltage, panel temperature and computing the sun incidence angle with the knowledge of the space craft position. The closed loop control of the fixed frequency SC converter is achieved by pulse-width modulating the gate drive of the MOSFET switches of the MPP tracking SC converter. The weight of the entire power system is approximately 750 grams.
Integration of Solid-State Nanopores in Microfluidic Networks via Transfer Printing of Suspended Membranes (2013)

Solid-state nanopores have emerged as versatile single-molecule sensors for applications including DNA sequencing, protein unfolding, micro-RNA detection, label-free detection of single nucleotide polymorphisms, and mapping of DNA-binding proteins involved in homologous recombination. While machining nanopores in dielectric membranes provides nanometer-scale precision, the rigid silicon support for the membrane contributes capacitive noise and limits integration with microfluidic networks for sample preprocessing. Herein, we demonstrate a technique to directly transfer solid-state nanopores machined in dielectric membranes from a silicon support into a microfluidic network. The resulting microfluidic-addressable nanopores can sense single DNA molecules at high bandwidths and with low noise, owing to significant reductions in membrane capacitance. This strategy will enable large-scale integration of solid-state nanopores with microfluidic upstream and downstream processing and permit new functions with nanopores such as complex manipulations for multidimensional analysis and parallel sensing in two and three-dimensional architectures.
Synthesis of β‐ and γ‐Carbolines by the Palladium‐Catalyzed Iminoannulation of Alkynes. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Reflection holograms recorded on poly-(N-vinylcarbazole) holographic material (1989)

We present preliminary results concerning reflection type hologramsi n poly(N-vinylcarbazole)(P VCz) that appear to confirm that PVCz is comparable to dichromated gelatin for thick reflection holograms.
Accessible glyco-tripod amphiphiles for membrane protein analysis (2015)

A new TPA (TPA-18) with high accessibility showed enhanced membrane protein stabilization, thereby being useful in membrane protein analysis.
Operation characteristics of three-terminal hybrid structure with multiple-quantum-well reflection modulator and heterojunction phototransistor (1991)

The operation characteristics of optically controlled three-terminal gates consisting of a multiple quantum well (MQW) reflection modulator and a heterojunction phototransistor (HPT) are discussed. It is found that the photonic gates, in which both components are electrically connected in series and parallel, operate as NOR and OR gates, respectively. The photonic gates exhibit a high contrast ratio of more than 20 dB as well as optical gain.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma (2015)

Peripheral T-cell lymphomas (PTCLs) are generally aggressive non-Hodgkin lymphomas with poor overall survival rates following standard therapy. One-third of PTCLs express interferon regulatory factor-4 (IRF4), a tightly regulated transcription factor involved in lymphocyte growth and differentiation. IRF4 drives tumor growth in several lymphoid malignancies and has been proposed as a candidate therapeutic target. Because direct IRF4 inhibitors are not clinically available, we sought to characterize the mechanism by which IRF4 expression is regulated in PTCLs. We demonstrated that IRF4 is constitutively expressed in PTCL cells and drives Myc expression and proliferation. Using an inhibitor screen, we identified nuclear factor κB (NF-κB) as a candidate regulator of IRF4 expression and cell proliferation. We then demonstrated that the NF-κB subunits p52 and RelB were transcriptional activators of IRF4. Further analysis showed that activation of CD30 promotes p52 and RelB activity and subsequent IRF4 expression. Finally, we showed that IRF4 transcriptionally regulates CD30 expression. Taken together, these data demonstrate a novel positive feedback loop involving CD30, NF-κB, and IRF4; further evidence for this mechanism was demonstrated in human PTCL tissue samples. Accordingly, NF-κB inhibitors may represent a clinical means to disrupt this feedback loop in IRF4-positive PTCLs.
Inhibition of Fibroblast Proliferation In Vitro Using Low-Level Infrared Light-Emitting Diodes (2012)

IR LLLT can effectively inhibit fibroblast proliferation in vitro without altering viability and holds promise for the treatment of scars.
Children with Invasive Staphylococcus aureus Disease Exhibit a Potently Neutralizing Antibody Response to the Cytotoxin LukAB (2013)

Despite the importance of Staphylococcus aureus as a common invasive bacterial pathogen, the humoral response to infection remains inadequately defined, particularly in children. The purpose of this study was to assess the humoral response to extracellular staphylococcal virulence factors, including the bicomponent leukotoxins, which are critical for the cytotoxicity of S. aureus toward human neutrophils. Children with culture-proven S. aureus infection were prospectively enrolled and stratified by disease type. Fifty-three children were enrolled in the study, of which 90% had invasive disease. Serum samples were obtained during the acute (within 48 h) and convalescent (4 to 6 weeks postinfection) phases, at which point both IgG titers against S. aureus exotoxins were determined, and the functionality of the generated antibodies was evaluated. Molecular characterization of clinical isolates was also performed. We observed a marked rise in antibody titer from acute-phase to convalescent-phase sera for LukAB, the most recently described S. aureus bicomponent leukotoxin. LukAB production by the isolates was strongly correlated with cytotoxicity in vitro, and sera containing anti-LukAB antibodies potently neutralized cytotoxicity. Antibodies to S. aureus antigens were detectable in healthy pediatric controls but at much lower titers than in sera from infected subjects. The discovery of a high-titer, neutralizing antibody response to LukAB during invasive infections suggests that this toxin is produced in vivo and that it elicits a functional humoral response.
Intra-arterial analysis of the best calibration methods to estimate aortic blood pressure (2018)

Brachial and aortic MAP/DBP were confirmed as the best calibration methods to estimate aortic SBP, but irrespective of calibration method, accuracy was significantly influenced by the level of SBP amplification. Thus, improved accuracy of estimated aortic SBP should be possible by closer consideration of SBP amplification or individual waveform characteristics that differ according to the level of SBP amplification.
Development of a Selective Inhibitor of Protein Arginine Deiminase 2 (2017)

Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidating the biological roles of this isozyme and may ultimately be useful for treating specific diseases in which PAD2 activity is dysregulated. To achieve this goal, we synthesized a series of benzimidazole-based derivatives of Cl-amidine, hypothesizing that this scaffold would allow access to a series of PAD2-selective inhibitors with enhanced cellular efficacy. Herein, we demonstrate that substitutions at both the N-terminus and C-terminus of Cl-amidine result in >100-fold increases in PAD2 potency and selectivity (30a, 41a, and 49a) as well as cellular efficacy (30a). Notably, these compounds use the far less reactive fluoroacetamidine warhead. In total, we predict that 30a will be a critical tool for understanding cellular PAD2 function and sets the stage for treating diseases in which PAD2 activity is dysregulated.
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes (2017)

Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges. In mice, a 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, followed by Ngn3-driven generation of insulin-producing β&nbsp;cells, resembling that observed during pancreatic development. FMD cycles restore insulin secretion and glucose homeostasis in both type 2 and type 1 diabetes mouse models. In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTOR activity and induce Sox2 and Ngn3 expression and insulin production. The effects of the FMD are reversed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition. These results indicate that a FMD promotes the reprogramming of&nbsp;pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D and T2D phenotypes in mouse models. PAPERCLIP.
Redox flow cell energy storage systems (1979)

NASA-Redox energy storage systems are being developed for ultimate use in stand-alone village power applications and distributed energy storage installations for electric utility service. In the former application, either solar photovoltaic arrays or wind turbines supply the primary power and an electrochemical storage system stores energy during times of excess power generation capability and delivers energy during times of insufficient power generation. Various electrochemical and non-electrochemical storage concepts are under consideration for these applications. Life cycle costs, simplicity of operation, complexity and state of technology are all determining factors in selecting systems for these important storage applications. NASA--Redox systems are electrochemical storage devices that use two fully soluble Redox couples, anode and cathode fluids, as active electrode materials separated by a highly selective ion exchange membrane. The reactants are contained in large storage tanks and pumped through a stack of Redox flow cells where the electrochemical reactions (reduction and oxidation) take place at porous carbon felt electrodes. A string or stack of these power producing cells is connected in series in a bipolar manner. Redox energy storage systems promise to be inexpensive and possess many features that provide for flexible design, long life, high reliability and minimal operation and maintenance costs. These features include independent sizing of power and storage capacity requirements and inclusion within the cell stack of a cell that monitors the state of charge of the system as a whole, and a rebalance cell which permits continuous correction to be made for minor side reactions that would tend to result in the anode fluid and cathode fluids becoming electrochemically out of balance.
A Blind Anti-Jammer Pre-Processor for GPS Receiver (2005)

In this letter, a new blind anti-jammer pre-processor is proposed for GPS receivers to alleviate performance degradation due to strong jammers. Since strong jammers have been successfully removed before despreading, the proposed scheme can effectively extract the signals-of-interest, leading to significant performance enhancement as compared with conventional methods.
Remote sensing space science enabled by the multiple instrument distributed aperture sensor (MIDAS) concept (2004)

The science capabilities and features of an innovative and revolutionary approach to remote sensing imaging systems aimed at increasing the return on future planetary science missions many fold are described. Our concept, called Multiple Instrument Distributed Aperture Sensor (MIDAS), provides a large-aperture, wide-field, diffraction-limited telescope at a fraction of the cost, mass and volume of conventional space telescopes, by integrating advanced optical imaging interferometer technologies into a multi-functional remote sensing science payload. MIDAS acts as a single front-end actively controlled telescope array for use on common missions, reducing the cost, resources, complexity, and risks of developing a set of back-end science instruments (SIs) tailored to each specific mission. By interfacing to multiple science instruments, MIDAS enables either sequential or concurrent SI operations in all functional modes. Passive imaging modes enable remote sensing at diffraction-limited resolution sequentially by each SI, as well as at somewhat lower resolution by multiple SIs acting concurrently on the image, such as in different wavebands. MIDAS inherently provides nanometer-resolution hyperspectral passive imaging without the need for any moving parts in the SI's. Our optical design features high-resolution imaging for long dwell times at high altitudes, <1m GSD from the 5000km extent of spiral orbits, thereby enabling regional remote sensing of dynamic planet surface processes, as well as ultra-high resolution of 2cm GSD from a 100km science orbit that enable orbital searches for signs of life processes on the planet surface. In its active remote sensing modes, using an integrated solid-state laser source, MIDAS enables LIDAR, vibrometry, surface illumination, ablation, laser spectroscopy and optical laser communications. The powerful combination of MIDAS passive and active modes, each with sequential or concurrent SI operations, increases potential science return for space science missions many fold. For example, on a mission to the icy moons of Jupiter, MIDAS enhances detailed imaging of the geology and glaciology of the surface, determining the geochemistry of surface materials, and conducting seismic and tidal studies.
Inhibition of Flower Induction by Some Inhibitors of Protease in the Short-day Plant <italic>Lemna paucicostata</italic> 6746 and the Long-day Plant <italic>Lemna gibba</italic> G3 (1990)

Four inhibitors of proteases, namely, bestatin, diisopropyl fluorophosphate, elastatinal and p-toluenesulfonyl-L-lysine chloromethyl ketone hydrochloride, were examined for their effects on flowering of a short-day plant Lemna paucicostata 6746 and a long-day plant Lemna gibba G3. Each of the inhibitors greatly inhibited the flowering of Lemna paucicostata 6746 that is normally induced by nitrogen deficiency. Bestatin or elastatinal given only during the first half of the culture period inhibited the flowering more clearly than when each was given during the latter half, suggesting that they inhibited the inductive process(es) involved in flowering rather than development of flower buds. Bestatin or elastatinal greatly inhibited the flowering of Lemna paucicostata 6746 induced by photoperiodic stimulus, ferricyanide and continuous far-red light. Simultaneous application of these two inhibitors was more effective in the inhibition of photoperiodically induced and ferricyanide-induced flowering than was each inhibitor alone. They also completely inhibited the photoperiodic flowering of Lemna gibba G3. These results suggest that the induction or activation of some proteases, probably followed by the degradation of some protein(s), is necessary for the induction of flowering in both these plants.
Active Front Steering Damping Control (2007)

This paper investigates the feasibility of steering-wheel damping enhancement control of an active front steer (AFS) system without the benefit of closed-loop feedback control and actuator control parameter adjustment. Through a comprehensive modeling and analysis of the AFS system, a simple, yet effective solution is reached to incorporate an additional control term to the actuator angular displacement command, which permits the fine-tuning of the steering wheel damping characteristics as a function of vehicle operation states beyond the pre-determined specification. Furthermore, the analysis also identifies a fundamental relationship between steering effort and the damping control, and thus leads to a proposed fine tuning of the Variable-Effort Steering for further development and implementation.