gebhart/patrepeval huggingface dataset:
Progress in and Technology of Low-Cost Silver Containing Thick-Film Conductors (1980)

Thick-film materials have been proved to possess economic, processing, and functional advantages over other technologies in the high-volume production of miniaturized circuits. Inherent in the adoption of thick-film technology for increasingly diverse applications has been the ability of thick-film materials suppliers to provide progressive performance improvements at lower cost concurrent with circuit manufacturer's needs. Since the first major commercial thick-film adoption in the early sixties when IBM adopted platinum-gold conductors and palladium-silver resistors in their 360 computers, rapid technological advances over the last decade have produced an increasing variety of hybrid circuits and networks. The wide adoption of thick-film technology in all segments of the electronic industry has placed increasing demands on performance and processing latitude. The development of low-cost silverbearing conductors is outlined and the evolution of technology improvements to present day systems is described. Initially the deficiencies of early Pd/Ag conductors are reviewed, particularly solder leach resistance and degradation of soldered adhesion following hightemperature storage, and focus is placed on the first Pd/Ag system which overcame these problems. Extension of this technology and subsequent improvements in both binders and vehicles to fulfill adhesion requirements to AI <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> substrates of Varying chemistries and to meet demands for high-speed printing are described also. In the second segment an overview of the present understanding of thickfilm conductor composites from a mechanistic point of view is given. The various types of binder systems commonly employed in conductors are discussed in terms of how they effect a bond between the sintered metal and the substrate, and the advantages and disadvantages of each type. Metallurgical aspects of conductor/solder connections are considered and their effects on bond reliability following exposure to high temperature are discussed. Rbeological considerations of paste design are presented and related to printing performance. In the final segment newer low-cost high-performance materials systems that have evolved over the past two years are considered. The technologies of each system are reviewed in terms of metallurgy, binder, and vehicle. Important functional properties are presented to illustrate cost/performance trade-offs. Special emphasis is given to a recently developed Ag conductor which has outstanding soldered adhesion even after 1000 h of storage at 150°C.
Candida albicans Cell Wall Ssa Proteins Bind and Facilitate Import of Salivary Histatin 5 Required for Toxicity (2006)

Fungicidal activity of Hst 5 is initiated by binding to cell surface proteins on Candida albicans, followed by intracellular transport to cytoplasmic effectors leading to cell death. As we identified heat shock 70 proteins (Ssa1p and/or Ssa2p) from C. albicans lysates that bind Hst 5, direct interactions between purified recombinant Ssa proteins and Hst 5 were tested by pull-down and yeast two-hybrid assays. Pulldown of both native complexes and those stabilized by cross-linking demonstrated higher affinity of Hst 5 for Ssa2p than for Ssa1p, in agreement with higher levels of interactions between Ssa2p and Hst 5 measured by yeast two-hybrid analyses. C. albicans ssa1Delta and ssa2Delta mutants were constructed to examine Hst 5 binding, translocation, and candidacidal activities. Both ssa1Delta and ssa2Delta mutants were indistinguishable from wild-type cells in growth and hyphal formation. However, C. albicans ssa2Delta mutants were highly resistant to the candidacidal activity of Hst 5, although the ssa1Delta mutant did not have any significant reduction in killing by Hst 5. Total cellular binding of 125I-Hst 5 in the ssa2Delta mutant was reduced to one-third that of wild-type cells, in contrast to the ssa1Delta mutant whose total cellular binding of Hst 5 was similar to the wild-type strain. Intracellular transport of Hst 5 was significantly impaired in the ssa2Delta mutant strain, but only mildly so in the ssa1Delta mutant. Thus, C. albicans Ssa2p facilitates fungicidal activity of Hst 5 in binding and intracellular translocation, whereas Ssa1p appears to have a lesser functional role in Hst 5 toxicity.
Incremental Parsing (1979)

An incremental parser is a device which is able to perform syntax analysis in an incremental way, avoiding complete reparsing of a program after each modification. The incremental parser presented extends the conventional LR parsing algorithm and its performance is compared with that of a conventional parser. Suggestions for an implementation and possible extensions to other parsing methods are also discussed.
Towards Understanding the Fundamentals of Mobility in Cellular Networks (2013)

Despite the central role of mobility in wireless networks, analytical study on its impact on network performance is notoriously difficult. This paper aims to address this gap by proposing a random waypoint (RWP) mobility model defined on the entire plane and applying it to analyze two key cellular network parameters: handover rate and sojourn time. We first analyze the stochastic properties of the proposed model and compare it to two other models: the classical RWP mobility model and a synthetic truncated Levy walk model which is constructed from real mobility trajectories. The comparison shows that the proposed RWP mobility model is more appropriate for the mobility simulation in emerging cellular networks, which have ever-smaller cells. Then we apply the proposed model to cellular networks under both deterministic (hexagonal) and random (Poisson) base station (BS) models. We present analytic expressions for both handover rate and sojourn time, which have the expected property that the handover rate is proportional to the square root of BS density. Compared to an actual BS distribution, we find that the Poisson-Voronoi model is about as accurate in terms of mobility evaluation as hexagonal model, though being more pessimistic in that it predicts a higher handover rate and lower sojourn time.
Results of the citalopram to enhance cognition in Huntington disease trial (2013)

There was no evidence that short-term treatment with citalopram improved executive functions in HD. Despite excluding patients with active depression, participants on citalopram showed improved mood, raising the possibility of efficacy for subsyndromal depression in HD.
Activation of a Biocatalytic Electrode by Removing Glucose Oxidase from the Surface—Application to Signal Triggered Drug Release (2014)

A biocatalytic electrode activated by pH signals was prepared with a multilayered nanostructured interface including PQQ-dependent glucose dehydrogenase (PQQ-GDH) directly associated with the conducting support and glucose oxidase (GOx) located on the external interface. GOx was immobilized through a pH-signal-cleavable linker composed of an iminobiotin/avidin complex. In the presence of GOx, glucose was intercepted at the external interface and biocatalytically oxidized without current generation, thus keeping the electrode in its nonactive state. When the pH value was lowered from pH 7.5 to 4.5 the iminobiotin/avidin complex was cleaved and GOx was removed from the interface allowing glucose penetration to the electrode surface where it was oxidized by PQQ-GDH yielding a bioelectrocatalytic current, thus switching the electrode to its active state. This process was used to trigger a drug-mimicking release process from another connected electrode. Furthermore, the pH-switchable electrode can be activated by biochemical signals logically processed by biocatalytic systems mimicking various Boolean gates. Therefore, the developed switchable electrode can interface biomolecular computing/sensing systems with drug-release processes.
Synthesis and Properties of a Selective Inhibitor of Homeodomain–Interacting Protein Kinase 2 (HIPK2) (2014)

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival, whose investigation has been hampered by the lack of specific inhibitors able to dissect its cellular functions. SB203580, a p38 MAP kinase inhibitor, has been used as a tool to inhibit HIPK2 in cells, but here we show that its efficacy as HIPK2 inhibitor is negligible (IC₅₀>40 µM). In contrast by altering the scaffold of the promiscuous CK2 inhibitor TBI a new class of HIPK2 inhibitors has been generated. One of these, TBID, displays toward HIPK2 unprecedented efficacy (IC₅₀ = 0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. We also provide evidence that TBID is cell permeable by showing that HIPK2 activity is reduced in cells treated with TBID, although with an IC₅₀ two orders of magnitude higher (about 50 µM) than in vitro.
Handling Unstructured Data Type in DB2 and Oracle (2014)

The objective of our work is to determine which mainstream object-relational database management systems (ORDMS) provide convenient facilities for the storage and manipulation of unstructured data objects. These objects, which consist of video, audio, photographs, and even executable code such as Java applets, are becoming readily employed by desktop, network, and Internet applications. Typically, these ORDMSs must store the objects in a manner by which they can be easily accessed, but more importantly, easily processed during either storage or retrieval. Our focus is on two of the ORDMS market leaders: IBM’s DB2 and Oracle. The salient facilities of DB2 and Oracle in handling object types are analyzed, considering their advantages and disadvantages.
Evaluation of Automated Reticulocyte Counts and Their Reliability in the Presence of Howell-Jolly Bodies (1994)

An automated reticulocyte procedure using a flow cytometer and the fluorescent dye thiazole orange was evaluated for clinical use. The mean reticulocyte count on 118 hematologically healthy adults was 1.56% (standard deviation [SD] 0.54), with virtually no difference in percentage between women and men. The mean absolute values were 68.4 x 10(9)/L (SD 24.6) and 75.7 x 10(9)/L (SD 27.2), respectively. When compared with the standard microscopic technique, the automated method showed excellent correlation (r = 0.98) and greatly improved precision (coefficient of variation [CV] 4.1%) over the manual method (CV 22.8%). Preanalytic storage of blood samples at 4 degrees C for up to 48 hours did not significantly affect results, nor did varying the incubation time of diluted samples from 1/2 to 2 hours. In a group of patients with appreciable numbers of Howell-Jolly bodies, automated reticulocyte counts were spuriously elevated. The difference between the manual and automated counts on these patients approximated the percentage of Howell-Jolly bodies observed on their Wright-Giemsa stained blood smears.
Interpreting Multiple Linear Regression: A Guidebook of Variable Importance (2020)

Multiple regression (MR) analyses are commonly employed in social science fields. It is also common for interpretation of results to typically reflect overreliance on beta weights (cf. Courville & Thompson, 2001; Nimon, Roberts, & Gavrilova, 2010; Zientek, Capraro, & Capraro, 2008), often resulting in very limited interpretations of variable importance. It appears that few researchers employ other methods to obtain a fuller understanding of what and how independent variables contribute to a regression equation. Thus, this paper presents a guidebook of variable importance measures that inform MR results, linking measures to a theoretical framework that demonstrates the complementary roles they play when interpreting regression findings. We also provide a data-driven example of how to publish MR results that demonstrates how to present a more complete picture of the contributions variables make to a regression equation. We end with several recommendations for practice regarding how to integrate multiple variable importance measures into MR analyses. Accessed 103,722 times on https://pareonline.net from April 29, 2012 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
REACTIVITY AND CRYOENZYMOLOGY OF ENZYMES IN THE CRYSTALLINE STATE (1977)

tional properties, and the analysis of spectroscopic properties in terms of molecular structure, were generally carried out for molecules in dilute solutions. Consequently, the application of X-ray diffraction techniques to determine the molecular structure
PPARs as determinants of the estrogen receptor lineage: use of synthetic lethality for the treatment of estrogen receptor-negative breast cancer (2017)

The nuclear receptor superfamily members PPARγ and PPARδ regulate gene expression associated with a multitude of pathways, including intermediary metabolism, angiogenesis, proliferation and inflammation (see reviews [1-3]). Recent developments using transgenic and knockout mice, as well as pharmacologic intervention with PPARγ and PPARδ agonists, have revealed a previously unknown relationship between PPARγ suppression and PPARδ activation that leads to the appearance of ER+ tumors, enabling a synthetic lethality approach by anti-ER therapy. The ability to selectively affect the ER+ lineage by modulating PPARγ and PPARδ activity represents a new clinical paradigm and opportunity to treat ER- cancer with PPARγ and PPARδ modulating agents, ultimately rendering them more responsive to adjuvant therapy.
An Overview of Device-to-Device Communications Technology Components in METIS (2016)

As the standardization of network-assisted device-to-device (D2D) communications by the Third Generation Partnership Project progresses, the research community has started to explore the technology potential of new advanced features that will largely impact the performance of 5G networks. For 5G, D2D is becoming an integrative term of emerging technologies that take an advantage of the proximity of communicating entities in licensed and unlicensed spectra. The European 5G research project Mobile and Wireless Communication Enablers for the 2020 Information Society (METIS) has identified advanced D2D as a key enabler for a variety of 5G services, including cellular coverage extension, social proximity, and communicating vehicles. In this paper, we review the METIS D2D technology components in three key areas of proximal communications—network-assisted multi-hop, full-duplex, and multi-antenna D2D communications—and argue that the advantages of properly combining cellular and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ad hoc</i> technologies help to meet the challenges of the information society beyond 2020.
Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys (1991)

Genetic and antigenic variation may be one means by which lentiviruses that cause AIDS avoid elimination by host immune responses. Genetic variation in the envelope gene (env) was studied by comparing the nucleotide sequences of 27 clones obtained from two rhesus monkeys infected with molecularly cloned simian immunodeficiency virus. All 27 clones differed from each other and differed from the input clone in the gp120 (SU) portion of the envelope gene. Nucleotide substitutions were shown to accumulate with time at an average rate of 8.5 per 1,000 per year in SU. Surprisingly, the majority of nucleotide substitutions (81%) resulted in amino acid changes. Variation in SU was not random but occurred predominantly in five discrete regions. Within these variable regions, a remarkable 98% of the nucleotide substitutions changed the amino acid. These results demonstrate that extensive sequence variability accumulates in vivo after infection with molecularly cloned virus and that selection occurs in vivo for changes in distinct variable regions in env.
Temperature-dependent characteristics of Teflon membranes used in mass spectrometry. (1975)

In vitro information is provided on the gas partial pressure/temperature relationship and on the membrane permeability/temperature relationship, when a special type of Teflon membrane is used with a mass spectrometer. Monitored pressures of oxygen, nitrogen, and carbon dioxide in an equilibrating gas mixture decreased with stepwise decreases in temperature from 37 to 18 degrees C. Permeability of membranes to all gases also decreased with decreasing temperature. Observed partial pressure changes were apparently due to temperature-induced changes in Teflon membrane permeability characteristics.
Structure and Chemical Synthesis of Amastatin (1979)

The structure of amastatin was elucidated to be [(2S,3R)-3-amino-2-hydroxy-5-methyl-hexanoyl]-l-valyl-l-valyl-l-aspartic acid, and was confirmed by chemical synthesis.
Effect of superplasticisers on the behaviour and properties of alkaline cements (2003)

This paper examines the effect of the latest generation of superplasticiser admixtures (based upon vinyl and polyacrylate copolymers) on certain properties and characteristics of alkaline cement pastes and mortars obtained by the alkaline activation of a blast-furnace slag and by the activation of a Class F fly ash. In the case of pastes and mortars derived from the slag subjected to an alkaline activation process, the nature of the admixture affects the activation process and the way in which the strength develops. However, this effect is much less marked in materials that have been obtained from the alkaline activation of fly ash.
<i>Self-Organized Criticality: Emergent Complex Behavior in Physical and Biological Systems</i> (1999)

Preface 1. Introduction 2. Characterization of the SOC state 3. Systems exhibiting SOC 4. Computer models 5. The search for a formalism 6. Is it SOC or is it not? Appendices.
Points-of-Interest Mining from People's Photo-Taking Behavior (2013)

Millions of geo-tagged photos are becoming available due to the widespread of photo-sharing websites. These social medias capture attractive points-of-interest and contain interesting photo-taking patterns. Massive amount of these user-oriented data produces new challenges and understanding people's photo-taking behavior is of great importance for local tourism-related businesses. This paper analyzes geotagged photos from Flickr for Queensland, a tourismintensive and the second largest state in Australia. We report interesting points-of-interest patterns and discuss these findings.
Binding of the EcoRII methyltransferase to 5-fluorocytosine-containing DNA. Isolation of a bound peptide (1992)

The properties of the interaction of 5-fluorocytosine-containing DNA with the EcoRII methyltransferase were studied. The DNA used was either a polymer synthesized in vitro, or a 20-mer containing one CCA/TGG sequence. The DNA could be methylated by the enzyme. In the process the enzyme formed a tight binding adduct with the DNA that could be identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Enzyme activity was inhibited by this interaction. The 20-mer could be used to titrate the active site of the enzyme. The DNA polymer formed a tight binding complex that could be identified following digestion of the DNA with pancreatic deoxyribonuclease or micrococcal nuclease. A peptide-DNA adduct could be isolated after digestion of the EcoRII-DNA adduct with staphylococcal protease V8 by high pressure liquid chromatography and polyacrylamide gel electrophoresis. Sequencing of the peptide indicated the DNA bound to a region of the protein that is conserved in all procaryotic DNA(cytosine-5)-methyltransferases. We have previously shown that this region contains a cysteine that can be photomethylated with adenosylmethionine. This region, in addition to forming part of, or being adjacent to, the AdoMet binding site, also forms part of the DNA binding site.
Contained Neural Style Transfer for Decorated Logo Generation (2018)

Making decorated logos requires image editing skills, without sufficient skills, it could be a time-consuming task. While there are many on-line web services to make new logos, they have limited designs and duplicates can be made. We propose using neural style transfer with clip art and text for the creation of new and genuine logos. We introduce a new loss function based on distance transform of the input image, which allows the preservation of the silhouettes of text and objects. The proposed method contains style transfer to only a designated area. We demonstrate the characteristics of proposed method. Finally, we show the results of logo generation with various input images.
Assessing the Level of Knowledge about Ebola Virus Disease among College Students (2017)

Objective: Ebola virus disease is becoming a public health emergency of international concern, but the study of knowledge about Ebola virus disease among college students is limited. This study aimed to assess the level of knowledge about Ebola virus disease among college students for offering the strategies to health education of Ebola virus disease. Methods: The stratified cluster sampling method was used and the investigation with self-administration and anonymous questionnaire included knowledge of Ebola virus disease and HIV/AIDS was conducted among 1200 college students who were enrolled from three colleges in Wuhu, China from May to July in 2015. Results: The correct answer rate of epidemic area of Ebola virus disease was the highest (71.37 %), the transmitting vector was the lowest (13.14 %). The average awareness rate of Ebola virus disease (0.381 ± 0.256) was significantly lower than that of HIV/AIDS (0.810 ± 0.220) (P < 0.05). The awareness rate of Ebola virus disease were significantly different in specialties, grades and registered residences (P < 0.05). And in HIV/AIDS, there were also significant differences in specialties, grades (P < 0.05). The medical students’ awareness rate of Ebola virus disease was generally higher than non-medical students’, freshmen and junior and above were higher than sophomore, and there was a decline trend in students from urban, town to rural (P < 0.05). Conclusion: The awareness rate of Ebola virus disease was lower comparing to HIV/AIDS among colleges students. It should strengthen the health education about Ebola virus disease toward different characteristics of college student.
Fast fabrication of curved microlens array using DMD-based lithography (2016)

Curved microlens array is the core element of the biologically inspired artificial compound eye. Many existing fabrication processes remain expensive and complicated, which limits a broad range of application of the artificial compound eye. In this paper, we report a fast fabrication method for curved microlens array by using DMD-based maskless lithography. When a three-dimensional (3D) target curved profile is projected into a two-dimensional (2D) mask, arbitrary curved microlens array can be flexibly and efficiently obtained by utilizing DMD-based lithography. In order to verify the feasibility of this method, a curved PDMS microlens array with 90 micro lenslets has been fabricated. The physical and optical characteristics of the fabricated microlens array suggest that this method is potentially suitable for applications in artificial compound eye.