gebhart/patrepeval huggingface dataset:
<title>Computer-Originated Hologram Lenses</title> (1980)

The capability of analyzing hologram lenses recorded with arbitrary wavefronts has been added to a holographic raytracing design program. The recording wavefronts are defined by analytical phase functions, for example, a two-dimensional polynominal expansion. The coefficients of the functional representations of the recording wavefronts are used as parameters to optimize the performance of an optical system containing the hologram lens. The optimum recording wavefronts are then produced with the help of computer-generated holo-grams. Several useful arbitrary wavefront phase functions are discussed. Design predictions and experimental results will be shown for a holographic Fourier transform lens recorded with the aid of a computer-generated hologram.
Characterisation of single-mode fibres by near-field measurement (1983)

A new technique for the determination of the refractive-index profile of single-mode optical fibres from a simple near-field measurement is proposed. This permits one to deduce accurately all the important parameters of the fibre.
Alpha seeding for support vector machines (2000)

Article Alpha seeding for support vector machines Share on Authors: Dennis DeCoste Machine Learning Systems Group, Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA Machine Learning Systems Group, Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CAView Profile , Kiri Wagstaff Department of Computer Science, Cornell University, 4156 Upson Hall, Ithaca, NY Department of Computer Science, Cornell University, 4156 Upson Hall, Ithaca, NYView Profile Authors Info & Claims KDD '00: Proceedings of the sixth ACM SIGKDD international conference on Knowledge discovery and data miningAugust 2000 Pages 345–349https://doi.org/10.1145/347090.347165Online:01 August 2000Publication History 42citation550DownloadsMetricsTotal Citations42Total Downloads550Last 12 Months7Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A novel method for the isolation of carboxypeptidase B. (1986)

Carboxypeptidase B was isolated from porcine pancreas by selective heat treatment of the autolyzed tissue at 60 degrees C and pH 6.0 the presence of phosphate ions. The heat treatment was followed by ammonium sulfate fractionation and ion-exchange in a batch system. The method could also be used for the isolation of carboxypeptidase B from beef pancreas.
Adaptive image segmentation using genetic and hybrid search methods (1995)

This paper describes an adaptive approach for the important image processing problem of image segmentation that relies on learning from experience to adapt and improve the segmentation performance. The adaptive image segmentation system incorporates a feedback loop consisting of a machine learning subsystem, an image segmentation algorithm, and an evaluation component which determines segmentation quality. The machine learning component is based on genetic adaptation and uses (separately) a pure genetic algorithm (GA) and a hybrid of GA and hill climbing (HC). When the learning subsystem is based on pure genetics, the corresponding evaluation component is based on a vector of evaluation criteria. For the hybrid case, the system employs a scalar evaluation measure which is a weighted combination of the different criteria. Experimental results for pure genetic and hybrid search methods are presented using a representative database of outdoor TV imagery. The multiobjective optimization demonstrates the ability of the adaptive image segmentation system to provide high quality segmentation results in a minimal number of generations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optimization methodology of composite panels (2006)

Two cases of biliary cholangiocarcinomas simulating an ovarian neoplasia are reported.
Multiple-Input Multiple-Output OFDM with Index Modulation (2015)

Orthogonal frequency division multiplexing with index modulation (OFDM-IM) is a novel multicarrier transmission technique which has been proposed as an alternative to classical OFDM. The main idea of OFDM-IM is the use of the indices of the active subcarriers in an OFDM system as an additional source of information. In this work, we propose multiple-input multiple-output OFDM-IM (MIMO-OFDM-IM) scheme by combining OFDM-IM and MIMO transmission techniques. The low complexity transceiver structure of the MIMO-OFDM-IM scheme is developed and it is shown via computer simulations that the proposed MIMO-OFDM-IM scheme achieves significantly better error performance than classical MIMO-OFDM for several different system configurations.
Protection against <i>Plasmodium falciparum</i> challenge induced in <i>Aotus</i> monkeys by liver‐stage antigen‐3‐derived long synthetic peptides (2008)

The vaccine potential of Plasmodium falciparum liver stage antigen-3 (LSA3) was investigated in Aotus monkeys using two long synthetic peptides corresponding respectively to an N-terminal non-repeat peptide (NRP) and repeat 2 (R2) region of the LSA3, adjuvanted by ASO2. Both 100-222 (NRP) and 501-596 repeat peptides induced effector B- and T-cell responses in terms of antigen-driven antibodies and/or specific IFN-gamma secretion. Animals challenged with P. falciparum sporozoites were protected following immunization with either the NRP region alone or the NRP combined with the R2 repeat region, as compared with controls receiving the adjuvant alone. These results indicate that the NRP may be sufficient to induce full, sterile protection and confirm the vaccine potential of LSA3 previously demonstrated in chimpanzees and in Aotus.
Cell proliferation following non-thermal plasma is related to reactive oxygen species induced fibroblast growth factor-2 release (2009)

Non-thermal dielectric barrier discharge plasma is currently being developed for a wide range of medical applications, including blood coagulation, malignant cell apoptosis, and wound healing. However, the effect of non-thermal plasma on the vasculature is unclear. Blood vessels are affected during plasma treatment of many tissues, and vessels themselves may be an important clinical plasma therapy target. We investigated the effect of non-thermal plasma treatment on endothelial cells, which line the inner surface of blood vessels. Non-thermal plasma treatment at short exposures (up to 30 seconds; 4 J/cm(2)) was relatively non-toxic to endothelial cells. Endothelial cells treated with plasma for 30 seconds demonstrated twice as much proliferation as untreated cells five days after plasma treatment. Proliferation was abrogated by a fibroblast growth factor-2 neutralizing antibody and reactive oxygen species inhibitors. This suggests that plasma-induced endothelial cell proliferation is caused by growth factor release following reactive oxygen species cell membrane damage. These data suggest that low power non-thermal plasma treatment is a potential novel therapy for promotion of endothelial cell mediated angiogenesis.
Surfactant‐Templated Mesostructuring of Zeolites: From Discovery to Commercialization (2015)

Slow diffusion of large reactant molecules through the micropores of zeolites has long been considered a major limitation to their performance in catalysis and separations. Syntheses of zeolites with larger micropores, reducing the size of zeolite crystals to nanometer scales, or introducing meso-sized (2–50 nm) or macro-sized (>50 nm) pores into zeolite crystals are three main approaches to alleviate the diffusional limitation. In the past 10–15 years, the third approach that introduces a hierarchy of porosity into traditionally microporous zeolite crystals saw significant progress. The surfactant-templated zeolite mesostructuring process described in this chapter produces hierarchical zeolites that contain the original micropores of the starting zeolite and newly introduced intracrystalline mesopores of well-controlled volumes and sizes that correspond to the size of the surfactant micelles. The mesoporous zeolites prepared by the simple postsynthetic modification approach has shown significant performance uplift in catalysis such as fluid catalytic cracking (FCC) and in chemical separations, for example, simulated moving bed separation of propane and propylene. Through the intensive development and commercialization work at Rive Technology, this technology has become a commercial reality, first in FCC applications, promoting significantly higher production of higher-valued liquid fuels (diesel and gasoline) while suppressing the formation of undesired side-products such as coke and gases in FCC units and allowing refiners to further optimize their operations throughout the refinery.
Transcriptional Analysis of Latent and Inducible Kaposi's Sarcoma-Associated Herpesvirus Transcripts in the K4 to K7 Region (2005)

Kaposi's sarcoma-associated herpesvirus (KSHV) is a gamma-2 herpesvirus with a genome containing a long unique coding region (LUR) flanked by GC-rich terminal repeat sequences. The LUR encodes approximately 90 annotated open reading frames (ORFs) with complex patterns of gene expression during viral latency, reactivation, and de novo infection. To identify unannotated KSHV genes, we examined the region between 21,500 and 30,000 bp of the KSHV LUR, representing approximately 8.5 kb of sequence. This region encodes seven known single-exon ORFs (K4, K4.1, K4.2, K5, K6, K7, and PAN), but previous computer analyses have failed to identify additional likely genes in the remaining 5.2 kb. We identified four novel transcripts using Northern blotting, phage library screening, and 5' rapid amplification of cDNA ends analysis in the region between ORFs K4.2 and K7. In vitro analysis of KSHV-infected primary effusion lymphoma cell lines in the presence of 12-O-tetradecanoylphorbol-13-acetate and phosphonoformic acid suggests that one latent transcript is coterminal with the previously annotated K3 gene encoding an ubiquitin-ligase known to downregulate major histocompatibility complex class I expression. This alternatively spliced transcript may contribute to KSHV adaptive immune evasion during latent infection. Other transcripts are inducible, including a 6.1-kb transcript that is the largest transcript found in the KSHV genome to date.
Design of Robust Differential Microphone Arrays (2014)

Differential microphone arrays (DMAs), due to their small size and enhanced directivity, are quite promising in speech enhancement applications. However, it is well known that differential beamformers have the drawback of white noise amplification, which is a major issue in the processing of wideband signals such as speech. In this paper, we focus on the design of robust DMAs. Based on the Maclaurin’s series approximation and frequency-independent beampatterns, the robust first-, second-, and third-order DMAs are proposed by using more microphones than the order plus one, and the corresponding minimum-norm filters are derived. Compared to the traditional DMAs, the proposed designs are more robust with respect to white noise amplification while they are capable of achieving similar directional gains.
Longevity improvement of optically activated, high gain GaAs photoconductive semiconductor switches (2000)

The longevity of high gain GaAs photoconductive semiconductor switches (PCSS) has been extended to over 100 million pulses. This was achieved by improving the ohmic contacts through the incorporation of a doped layer that is very effective in the suppression of filament formation, alleviating current crowding. Damage-free operation is now possible at much higher current levels than before. The inherent damage-free current capacity of the bulk GaAs itself depends on the thickness of the doped layers and is at least 100 A for a dopant diffusion depth of 4 /spl mu/m. This current could be increased by connecting and triggering parallel switches. The contact metal has a different damage mechanism and the threshold for damage (/spl sim/40 A) is not further improved beyond a dopant diffusion depth of about 2 /spl mu/m. In a diffusion-doped contact switch, the switching performance is not degraded at the onset of contact metal erosion, unlike a switch with conventional contacts. For fireset applications operating at a 1 kV/1 kA levels and higher, doped contacts have not yet resulted in improved longevity. The authors employ multi-filament operation and InPb solder/Au ribbon wirebonding to demonstrate >100 shot lifetime at 1 kV/1 kA.
CAR-T Cells Based on Novel BCMA Monoclonal Antibody Block Multiple Myeloma Cell Growth (2018)

The cell-surface protein B cell maturation antigen (BCMA, CD269) has emerged as a promising target for CAR-T cell therapy for multiple myeloma. In order to create a novel BCMA CAR, we generated a new BCMA monoclonal antibody, clone 4C8A. This antibody exhibited strong and selective binding to human BCMA. BCMA CAR-T cells containing the 4C8A scFv were readily detected with recombinant BCMA protein by flow cytometry. The cells were cytolytic for RPMI8226, H929, and MM1S multiple myeloma cells and secreted high levels of IFN-γ in vitro. BCMA-dependent cytotoxicity and IFN-γ secretion were also observed in response to CHO (Chinese Hamster Ovary)-BCMA cells but not to parental CHO cells. In a mouse subcutaneous tumor model, BCMA CAR-T cells significantly blocked RPMI8226 tumor formation. When BCMA CAR-T cells were given to mice with established RPMI8226 tumors, the tumors experienced significant shrinkage due to CAR-T cell activity and tumor cell apoptosis. The same effect was observed with 3 humanized BCMA-CAR-T cells in vivo. These data indicate that novel CAR-T cells utilizing the BCMA 4C8A scFv are effective against multiple myeloma and warrant future clinical development.
Ultrafast Detection of SARS-CoV-2 Spike Protein (S) and Receptor-Binding Domain (RBD) in Saliva Using Surface-Enhanced Raman Spectroscopy (2022)

Controlling contagious diseases necessitates using diagnostic techniques that can detect infection in the early stages. Although different diagnostic tools exist, there are still challenges related to accuracy, rapidity, cost-effectiveness, and ease of use. Surface-enhanced Raman spectroscopy (SERS) is a rapid, simple, less expensive, and accurate method. We continue our previous work published on SERS detection of the SARS-CoV-2 receptor-binding domain (RBD) in water. In this work, we replace water with saliva to detect SARS-CoV-2 proteins at very low concentrations and during a very short time. We prepared a very low concentration of 10−9 M SARS-CoV-2 spike protein (S) and SARS-CoV-2 receptor-binding domain (RBD) in saliva to mimic a real case scenario. Then, we drop them on a SERS substrate. Using modified SERS measurements on the control and the sample containing the biomolecules, confirmed the sensitivity of the target identification. This technique provides different diagnostic solutions that are fast, simple, non-destructive and ultrasensitive. Simulation of the real-world of silicon wire covered with silver and gold, were performed using an effective and accurate tool, COMSOL Multiphysics software, for the enhancement properties study.
Identification of a Novel, Selective GABA<sub>A</sub>α5 Receptor Inverse Agonist Which Enhances Cognition (2003)

In pursuit of a GABA(A) alpha5-subtype-selective inverse agonist to enhance cognition, a series of 6,7-dihydro-2-benzothiophen-4(5H)-ones has been identified as a novel class of GABA(A) receptor ligands. These thiophenes have higher binding affinity for the GABA(A) alpha5 receptor subtype compared to the GABA(A) alpha1, alpha2, and alpha3 subtypes, and several analogues exhibit high GABA(A) alpha5 receptor inverse agonism. 6,6-Dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one (43) has been identified as a full inverse agonist at the GABA(A) alpha5 receptor and is functionally selective over the other major GABA(A) receptor subtypes. 43 readily penetrates into the CNS to give selective occupancy of GABA(A) alpha5 receptors. In addition, 43 enhances cognitive performance in rats in the delayed 'matching-to-place' Morris water maze test-a hippocampal-dependent memory task-without the convulsant or proconvulsant activity associated with nonselective, GABA(A) receptor inverse agonists.
Genomics via Optical Mapping II: Ordered Restriction Maps (1997)

In this paper, we describe our algorithmic approach to constructing ordered restriction maps based on the data created from the images of population of individual DNA molecules (clones) digested by restriction enzymes. The goal is to devise map-making algorithms capable of producing high-resolution, high-accuracy maps rapidly and in a scalable manner. The resulting software is a key component of our optical mapping automation tools and has been used routinely to map cosmid, lambda and BAC clones. The experimental results appear highly promising.
Field emission from reconstructed heavily phosphorus-doped homoepitaxial diamond (111) (2006)

We report about field emission from reconstructed phosphorus-doped diamond surfaces. In order to reconstruct the surface, annealing at 950°C for 60min in a high vacuum system has been applied. Field emission shows the lowest threshold field for the reconstructed surface of 16V∕μm, while the threshold fields for oxidized and hydrogen-terminated surface are 28 and 44V∕μm, respectively. A model is introduced to discuss these results, which takes into account effective electron affinities and tunneling of electrons from conduction band and donor levels.
A novel multi-level IC-compatible surface microfabrication technology for MEMS with independently controlled lateral and vertical submicron transduction gaps (2017)

An above-IC compatible multi-level MEMS surface microfabrication technology based on a silicon carbide structural layer is presented. The fabrication process flow provides optimal electrostatic transduction by allowing the creation of independently controlled submicron vertical and lateral gaps without the need for high resolution lithography. Adopting silicon carbide as the structural material, the technology ensures material, chemical and thermal compatibility with modern semiconductor nodes, reporting the lowest peak processing temperature (i.e. 200 °C) of all comparable works. This makes this process ideally suited for integrating capacitive-based MEMS directly above standard CMOS substrates. Process flow design and optimization are presented in the context of bulk-mode disk resonators, devices that are shown to exhibit improved performance with respect to previous generation flexural beam resonators, and that represent relatively complex MEMS structures. The impact of impending improvements to the fabrication technology is discussed.
Comparison of effectiveness of cefovecin, doxycycline, and amoxicillin for the treatment of experimentally induced early Lyme borreliosis in dogs (2015)

Convenia was efficacious against B. burgdorferi sensu stricto infection in dogs as determined by serological testing, PCR and histopathology results. Convenia provides an additional and effective treatment option for Lyme Disease in dogs.
Enterprise Digital Rights Management for Document Protection (2017)

An insider contributes maximum to the leakage ofsensitive information knowingly or unknowingly in an enterprise. Therefore, the need for persistent protection of such informationis critical. At the same time, enterprise friendly features forrights and ownership management are of great importance to adigital rights management (DRM) system considering thedynamism of enterprise workforce in a large enterprise. Thecurrent enterprise DRM systems have emphasized on offeringpersistent protection but do not support integration into existingenterprise infrastructure and workflows. In this paper, wepresent the enterprise digital rights management (eDRM) systemthat provides persistent protection to documents usingcryptographic methods, and also includes enterprise friendly features.
Segmented Electrode Hall Thruster (2006)

Thrust, thrust efficiency, and plume divergence were measured for a 9 cm diam laboratory model Hall thruster with segmented electrodes in the discharge channel. Several geometries with graphite nonemissive electrodes, and one with a tungsten emissive electrode were tested and compared to a baseline configuration with all electrodes replaced by boron nitride segments. To within measurement uncertainty, thrust and thrust efficiency were unaffected by insertion of electrodes, with the exception of reduced efficiency for a configuration which resulted in a 20% increase in discharge current. Maximum plume half-angle reductions of 4 deg were obtained with emissive and nonemissive electrodes.
SUBMARINE: an architecture for IP routing over large NBMA networks (1999)

As communications networks grow in both speed and scale, there is a need to switch packets at higher speeds. One approach is to use fast switches that operate at the datalink layer (layer 2) to build a high-performance "cloud" for interconnecting network layer routers. The use of ATM for the layer 2 network provides a number of advantages when the network is shared among multiple services and when additional capabilities that are supported well at layer 2, such as fine-grained per-flow QoS, are needed. This paper describes a robust and efficient solution to the problem of supporting IP over a large non-broadcast multiple-access (NBMA) network, such as ATM. The solution, known as SUBMARINE, calculates loop-free shortcut routes across the NBMA network. SUBMARINE builds on existing IP routing protocols, is designed to scale to multiple areas within a single autonomous system, and makes minimal changes to the IP forwarding process.
Real-time adaptation of mobile antenna impedance matching (2010)

This paper presents a simple, low cost adaptive antenna tuning module that is used in conjunction with a small, simplified mobile phone antenna. It is shown that the transmit and receive VSWR can be kept below 3:1 over the frequency ranges 824-960 and 1710-2170 MHz with and without the effect of the user's head and hand.
High-Resolution Mapping of the Physical Location of the Tomato Cf<i>-</i>2<i />Gene (1995)

To isolate the tomato Cf-2 resistance gene by map-based cloning, plants recombinant for RFLP markers close to Cf-2 were selected by exploiting the flanking morphological markers yv (yellow virescent) and tl (thiaminless). Using these recombinants, a high-resolution linkage map of the region encompassing the Cf-2 gene has been generated containing several new RFLP markers. Mapping of two YAC clones carrying Lycopersicon esculentum and L. peruvianum DNA, indicates that in both genotypes the physical distance between the two closet flanking markers is less than 40 kb. This study also positions Cf-2 relative to the Mi gene, which confers resistance to root-knot nematodes.