gebhart/patrepeval huggingface dataset:
β-Primeverosidase Relationship with Floral Tea Aroma Formation during Processing of Oolong Tea and Black Tea (2000)

Flavor is one the most important factors to determine the quality of beverages. Tea aroma, especially floral aroma liberated from brewed oolong tea and black tea, is so attractive. This study covers the molecular basis of the floral aroma formation during the tea processing. Previous work demonstrated the tea aroma precursors of geraniol, linalool, etc. as β-primeverosides (6-O-β-D-xylopyranosyl-β-D-glucopyranosides) from the tea leaves (Camellia sinensis var. sinensis cvs. Shuixian and Maoxie) which can be processed to oolong tea. We have also purified β-primeverosidases from fresh leaves of cv. Yabukita for Japanese green tea, cv. Shuixian for oolong tea and a cultivar of C. s. var. assamica for black tea. The molecular weight of each enzyme was shown to be 60,500, 60,200 and 60,300 by TOFMS, respectively. The enzymatic characteristics (optimum temperature, 45 °C; stable temp., 40-45 °C; optimum pH, 4; pH stability, pH 3-5; specific activity, 0.90-0.99 unit/mg) were very similar to each other. The enzyme was confirmed to effectively hydrolyze the aroma precursors, β-primeverosides as well as 6-O-β-D-apiofuranosyl-β-D-glucopyranoside, into disaccharides and each aglycon without further hydrolysis. Most of the alcoholic tea aroma, which contribute to the floral tea aroma, are primarily stored as disaccharide glycosides (β-primeverosides and 6-O-β-D-apiofuranosyl-β-D-glucopyranosides) and generated by the action of a specific enzyme, β-primeverosidase, during the fermentation process of tea manufacturing.
64.4: Smart Algorithms for Local Dimming LED Backlight (2008)

Abstract To reduce power consumption and improve image quality including contrast ratio and color gamut, LED backlight units (BLUs) consisting of many small blocks in 2‐dimensional space are implemented. Either white‐gray‐level luminance or color is controlled by the local dimming LED BLU. However, such a BLU can induce various recognizable artifacts. A method is proposed for exact block luminance calculation along with a new algorithm to correct local dimming artifacts. A new concept of color classes has also been developed to achieve extremely wide color gamut and to minimize color related artifacts.
PTD4‐apoptin protein therapy inhibits tumor growth <i>in vivo</i> (2009)

Apoptin protein harbors tumor-selective cell death activity, which makes it a potential anticancer therapy candidate. This study reports an apoptin therapy approach based on protein transduction domain 4 (PTD4)-mediated transduction of recombinant apoptin protein. In vitro, the PTD4-apoptin fusion protein is located in the nucleus and induces cell death in, e.g., human hepatocarcinoma HepG2 cells. In normal human L-02 hepatocytes, PTD4-apoptin protein retained mainly cytoplasmic and did not induce detectable levels of cell death, illustrating that the PTD4 domain does not affect apoptin's tumor-selective characteristics. In vivo, liver, cervix and gastric carcinoma xenografts treated with PTD4-apoptin protein for 6 days via the tumor epidermis exhibited a significant tumor growth inhibition because of apoptin-mediated cell death. In addition, treatment of human hepatocarcinoma xenografts during 3 weeks showed that PTD4-apoptin protein has significant anticancer activity, whereas control treatment with PTD4-enhanced green fluorescence protein or saline did not. Cell death and disruption of the tumor integrity were apparent in the PTD4-apoptin transduced xenografted tumors. As important, although PTD4-apoptin protein could be detected in the epidermal tissue covering the subcutaneous tumor tissue and in several organs, such as liver and brain, of the treated mice, no tissue disruption or signs of cell death could be detected. Our in vivo data reveal that apoptin protein delivery constitutes a novel powerful and safe anticancer therapy.
ACK1 Tyrosine Kinase Interacts with Histone Demethylase KDM3A to Regulate the Mammary Tumor Oncogene HOXA1 (2014)

Hormone therapy with the selective estrogen-receptor modulator tamoxifen provides a temporary relief for patients with estrogen receptor α (ER)-positive breast cancers. However, a subset of patients exhibiting overexpression of the HER2 receptor tyrosine kinase displays intrinsic resistance to tamoxifen therapy. Therefore, elucidating the mechanisms promoting the estrogen (E2)-independent ER-regulated gene transcription in tamoxifen-resistant breast tumors is essential to identify new therapeutic avenues to overcome drug resistance and ameliorate poor prognosis. The non-receptor tyrosine kinase, ACK1 (also known as TNK2), has emerged as a major integrator of signaling from various receptor tyrosine kinases including HER2. We have uncovered that heregulin-mediated ACK1 activation promoted ER activity in the presence of tamoxifen, which was significantly down-regulated upon ACK1 knockdown or inhibition of ACK1 by small molecule inhibitors, AIM-100 or Dasatinib. We report that ACK1 phosphorylates the ER co-activator, KDM3A, a H3K9 demethylase, at an evolutionary conserved tyrosine 1114 site in a heregulin-dependent manner, even in the presence of tamoxifen. Consistent with this finding, ACK1 activation resulted in a significant decrease in the deposition of dimethyl H3K9 epigenetic marks. Conversely, inhibition of ACK1 by AIM-100 or Dasatinib restored dimethyl H3K9 methylation marks and caused transcriptional suppression of the ER-regulated gene HOXA1. Thus, by its ability to regulate the epigenetic activity of an ER co-activator KDM3A, ACK1 modulates HOXA1 expression in the absence of E2, conferring tamoxifen resistance. These data reveal a novel therapeutic option, suppression of ACK1 signaling by AIM-100 or Dasatinib, to mitigate HOXA1 up-regulation in breast cancer patients displaying tamoxifen resistance.
Detecting Camouflaged Content Polluters (2017)

The connectivity and openness of the Internet have cultivated a blistering expansion of online media websites. However, the culture of openness also makes the emerging platforms an effective channel for content pollution, such as fraud, phishing, and other online abuses. To complicate the problem, content polluters actively manipulate the characteristics of the Internet through establishing links with normal users and blending the malicious information with legitimate content. The manipulated links and content, being used as camouflage, make it very intricate to detect content polluters. Recent work has investigated camouflaged fraud in networks. However, due to the lack of availability of label information for camouflaged content, it is challenging to detect content polluters with traditional approaches. In this paper, we make the first attempt on detecting camouflaged content polluters. In order to evaluate the proposed approach, we conduct experiments on real-world data. The results show that our method achieves better results than existing approaches.
Il viaggio di Meshullam ben Menachem da Volterra (1992)

Nel contributo si analizza il diario di viaggio (redatto in ebraico) di Meshullam da Volterra, cercando di evidenziare quali fossero le modalità di rapporto con il mondo non cristiano e l'atteggiamento del viaggiatore nei confronti dell'esotico.
Elevated plasma phenylalanine concentrations may adversely affect bone status of phenylketonuric mice (2002)

Children with phenylketonuric (PKU) are at risk for fractures. This study used a PKU murine model (PAH(enu-2)) to evaluate effects of moderate dietary protein restriction and elevated plasma phenylalanine concentration impact upon bone status. Fifty-four male weanling PKU and control mice were assigned to either an elemental phenylalanine (Phe)-restricted diet (treated) or Phe-unrestricted diet (untreated) with low or normal protein levels for 56 days. Untreated mice and control mice received equal amounts of dietary Phe; treated mice consumed prescribed dietary Phe to maintain plasma Phe concentrations between 120 and 480micromol/L. Plasma Phe, osteocalcin, and urine deoxypyridinoline (DPD)/creatinine were analysed at baseline and at days 28 and 56. Femur strength, bone mineral density (BMD) and bone mineral content (BMC) were analysed at day 56. Moderate protein restriction did not significantly affect bone status. Mean plasma Phe concentrations were significantly greater in untreated vs treated and control mice (p < 0.0001). Total body weight was significantly less in untreated vs control mice (p < 0.01). Mean femur weight was reduced in untreated mice vs both treated and control mice (p < 0.03). Untreated mice had smaller mean femur length than control mice (p < 0.002). Femur strength was greater in treated mice compared to control mice (p < 0.01) but not compared to untreated mice. No significant difference among groups was found in BMD and BMC. At day 56 there was a statistical trend (p < 0.056) towards higher urine DPD/creatinine excretion in untreated mice than in treated mice. Plasma Phe concentration was positively correlated with urine DPD/creatinine. These data suggested that hyperphenylalaninaemia may adversely affect bone status in PKU mice.
Epigenetic silencing of ARRDC3 expression in basal-like breast cancer cells (2014)

Arrestin domain-containing 3 (ARRDC3) is a tumor suppressor whose expression is either lost or suppressed in basal-like breast cancer (BLBC). However, the mechanism by which BLBC suppresses ARRDC3 expression is not established. Here, we show that expression of ARRDC3 in BLBC cells is suppressed at the transcriptional level. Suppression of ARRDC3 expression in BLBC cells involves epigenetic silencing as inhibitors of class III histone deacetylases (HDACs) significantly restores ARRDC3 levels in BLBC cells. SIRT2, among class III HDACs, plays a major role in epigenetic silencing of ARRDC3 in MDA-MB-231 cells. Acetylation levels of the ARRDC3 promoter in BLBC cells is significantly lower than that of other sub-types of BC cells. Chromatin immunopreciptitation analysis established SIRT2 binding at ARRDC3 promoter in BLBC cells. Our studies indicate that SIRT2 dependent epigenetic silencing of ARRDC3 is one of the important events that may contribute to the aggressive nature of BLBC cells.
1,2,4-Triazines in the Synthesis of Bipyridine Bisphenolate ONNO Ligands and Their Highly Luminescent Tetradentate Pt(II) Complexes for Solution-Processable OLEDs (2018)

This article describes a convenient method for the synthesis of ONNO-type tetradentate 6,6'-bis(2-phenoxy)-2,2'-bipyridine (bipyridine bisphenolate, BpyBph) ligands and their platinum(II) complexes. The methodology includes the synthesis of 1,2,4-triazine precursors followed by their transformation to functionalized pyridines by the Boger reaction. Two complementary routes employing 3,3'- and 5,5'-bis-triazines allow a modification of the central pyridine rings in different positions, which was exemplified by the introduction of cyclopentene rings. The new ligands were used to prepare highly luminescent ONNO-type Pt(II) complexes. The position of the cyclopentene rings significantly influences the solubility and photophysical properties of these complexes. Derivatives with closely positioned cyclopentene rings are soluble in organic solvents and proved to be the best candidate for solution-processable organic light-emitting devices (OLEDs), showing efficient single-dopant candlelight electroluminescence.
Synthesis and reactivity of dinuclear copper complexes having a m-xylyl spacer between coordination units (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and reactivity of dinuclear copper complexes having a m-xylyl spacer between coordination unitsThomas N. Sorrell, Vivian A. Vankai, and Martha L. GarrityCite this: Inorg. Chem. 1991, 30, 2, 207–210Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ic00002a013https://doi.org/10.1021/ic00002a013research-articleACS PublicationsRequest reuse permissionsArticle Views315Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural diversity and domain composition of a unique collagenous fragment (intima collagen) obtained from human placenta (1983)

Intima collagen was obtained from pepsin digests of human placenta in two forms, which differ to some extent in the size of their constituent polypeptide chains (Mr 50 000-70 000). These chains are connected by disulphide bonds to large aggregates. The aggregates are arranged in a triple-helical conformation with a remarkably high thermal stability (Tm 41-62 degrees C) and are resistant to further proteolytic digestion. Reduction of as little as 5% of the disulphide bonds produces mainly monomeric triple helices (Mr about 160 000) with Tm 32 degrees C. Partially reduced material can be separated into triple-helical and non-collagenous domains by proteolysis. Pepsin releases a collagenous component with chains of Mr 38 000. Bacterial collagenase liberates two non-collagenous segments (Mr 15 000-30 000) rich in cystine. Treatment with collagenase before reduction separates intima collagen into a large fragment composed of collagenous (Tm 41 degrees C) and non-collagenous structures and a single non-collagenous segment. The data support the electron-microscopical model of intima collagen [Furthmayr, Wiedemann, Timpl, Odermatt & Engel (1983) Biochem. J. 211, 303-311], indicating that the basic unit of the fragment consists of a continuous triple helix joining two globular domains.
Connection admission control for differentiating priority traffic on public networks (2003)

The public network has traditionally been unable to adequately deal with defense and disaster recovery communications, because overloads that occur during crises cause degraded resource access to all users, no matter how important. For public broadband networks to be effective for defense and disaster recovery multimedia communications, they must dynamically recognize some connections as having greater importance than others and allocate resources accordingly. A new approach to connection admission control is proposed that uses an upper limit policy to optimize the admission of connections based on the weighted sum of blocking across traffic classes. This optimization approach can be used for arbitrarily large networks and numbers of traffic classes and results in a very simple algorithm that could be implemented on standard network hardware. This work is also the first to demonstrate that the use of an upper limit policy is superior to traditional approaches of adding extra capacity or partitioning capacity, both in the amount of resources required and in sensitivity to load variations. An upper limit policy is also shown to be much faster to implement where a large overload occurs from a disaster event.
Pain reduction realized with extracorporeal shock wave therapy for the treatment of symptoms associated with interstitial cystitis/bladder pain syndrome—A prospective, multicenter, randomized, double‐blind, placebo‐controlled study (2020)

A reduction in pain was discovered in this trial assessing ESWT in patients with IC/BPS but OSS, which was the primary outcome parameter, was not improved.
Fast data-driven learning of parallel MRI sampling patterns for large scale problems (2021)

In this study, a fast data-driven optimization approach, named bias-accelerated subset selection (BASS), is proposed for learning efficacious sampling patterns (SPs) with the purpose of reducing scan time in large-dimensional parallel MRI. BASS is applicable when Cartesian fully-sampled k-space measurements of specific anatomy are available for training and the reconstruction method for undersampled measurements is specified; such information is used to define the efficacy of any SP for recovering the values at the non-sampled k-space points. BASS produces a sequence of SPs with the aim of finding one of a specified size with (near) optimal efficacy. BASS was tested with five reconstruction methods for parallel MRI based on low-rankness and sparsity that allow a free choice of the SP. Three datasets were used for testing, two of high-resolution brain images ([Formula: see text]-weighted images and, respectively, [Formula: see text]-weighted images) and another of knee images for quantitative mapping of the cartilage. The proposed approach has low computational cost and fast convergence; in the tested cases it obtained SPs up to 50 times faster than the currently best greedy approach. Reconstruction quality increased by up to 45% over that provided by variable density and Poisson disk SPs, for the same scan time. Optionally, the scan time can be nearly halved without loss of reconstruction quality. Quantitative MRI and prospective accelerated MRI results show improvements. Compared with greedy approaches, BASS rapidly learns effective SPs for various reconstruction methods, using larger SPs and larger datasets; enabling better selection of sampling-reconstruction pairs for specific MRI problems.
Molecular sieving characteristics of the cultured endothelial monolayer (1987)

We examined the selectivity of the bovine pulmonary artery endothelial monolayer in vitro to molecules of different sizes. The cultured bovine pulmonary endothelial monolayer was grown on a gelatinized filter and the transendothelial transport was studied by determining the permeability of molecules ranging from 182 to 340,000 daltons under diffusion conditions. The permeabilities across the cultured bovine endothelium were modeled according to cylindrical pore theory. The data were best fit by a two-pore model with radii 65 A and 304 A and a ratio of small to large pores of 160:1. The results indicate that the cultured endothelial monolayer is a selective barrier to molecules of different sizes and that the molecular selectivity is consistent with a diffusional pathway through endothelial pore equivalents. The cultured endothelial monolayer is a useful system for studying the permeability characteristics of the endothelial barrier.
Java Modelling Tools: an Open Source Suite for Queueing Network Modelling andWorkload Analysis (2006)

The Java Modelling Tools (JMT) is an open source suite for performance evaluation, capacity planning and modelling of computer and communication systems. The suite implements numerous state-of-the-art algorithms for the exact, asymptotic and simulative analysis of queueing network models, either with or without product-form solution. Models can be described either through wizard dialogs or with a graphical user-friendly interface. The suite includes also a workload analysis tool based on clustering techniques.
Diabetes and Driving (2006)

The issue of traffic safety of patients with diabetes is rising on political as well as scientific levels. Driving by diabetic patients may be impaired by three factors: hyperglycemia, hypoglycemia, and diabetes complications. Management of diabetic patients is progressively aiming at near normoglycemia (1,2). Consequently, the rate of hypoglycemia and hypoglycemia unawareness has markedly increased (3–8). These factors could pose an increased threat to diabetic patients’ fitness to drive. Current legal restrictions regarding diabetes and driving privileges vary throughout the world, but laws are generally prompted by the impending danger of hypoglycemia during driving. To research the various aspects of diabetes and driving, several study methods have been applied. In consideration of dissenting opinions and laws, rules, and regulations, we will discuss in this article the currently available data on diabetes and driving, potential pitfalls in research, and give recommendations for future research.

In modern traffic, the increasing age of drivers (9) and their medical conditions can be risk factors for traffic incidents and accidents. The amounting prevalence of diabetes also leads to an increased number of diabetic drivers. Driving by diabetic patients may be impaired by three factors: hyperglycemia, hypoglycemia, and diabetes complications.

In recent years, it has become apparent that acute hyperglycemia, and possibly also chronic hyperglycemia, may be associated with cognitive function loss (10–15). However, the cognitive dysfunction occurring during hypoglycemia is most striking (16–18). After the Diabetes Control and Complications Trial (1) and the U.K. Prospective Diabetes Study (2), which showed that diabetes complications are reduced with tight glucose control, management of diabetic patients is progressively aiming at near normoglycemia. Consequently, the rate of hypoglycemia has increased. We now know that even a single episode of hypoglycemia leads to impaired hypoglycemia awareness (19). Hypoglycemia unawareness currently affects ∼25% …
Approach Toward Parametric Design of Typical Parts and Parts-Library Based on UG (2011)

With the basic tool of the powerful secondary development function of UG NX and based on the analysis of the characteristics of typical mechanical parts, put forward a digital method and system of parametric design for the parts, created the relavent parts-library for the system. In the parametric design, mechanical parts were divided roughly into four classes according to GT. The characteristic parameters were selected from the shared attributes of each class. By utilizing the secondary development tool of UG/Open, compiled, connected by means of Visual C++, and realized the integration of a mechanical-part orientated UG system for parametric design with user-friendly interface and counterpart dynamic-link library files. Taking characteristic parameters of typical parts as the variables, different models were established through man-computer interaction according to size constraint, and then created the parts-library. The system has worked successfully taking the inner gear as example of the typical part, and given expected result. It is shown from the execution of system that the current system with the virtual parts-library can respond the designer's demand fast, avoid repetition, save manpower and time, and improve the speed of new product development significantly.
On the Choice of Longitudinal Models for the Analysis of Antitumor Efficacy in Mouse Clinical Trials of Patient-derived Xenograft Models (2023)

This work brings new arguments to a controversy on the correct choice of statistical modeling methods for the analysis of MCTs. We conclude that mixed models are more robust than joint models.
Oxytocin Involvement in SSRI-Induced Delayed Ejaculation: A Review of Animal Studies (2007)

Preliminary data suggest that the severity of chronic SSRI treatment-induced delayed ejaculation and the differences between the various SSRIs in inducing ejaculation delay is related to gradual desensitization of 5-HT(1A) receptors on oxytocin neurons.