gebhart/patrepeval huggingface dataset:
Daidzin, an Antioxidant Isoflavonoid, Decreases Blood Alcohol Levels and Shortens Sleep Time Induced by Ethanol Intoxication (1994)

The extract from an edible vine, Pueraria lebata, has been reported to be efficacious in lessening alcohol intoxication. In this study, we have tested the efficacy of one of the major components, daidzin, from this plant extract. When ethanol (40% solution, 3 g/kg body weight) was given to fasted rats intragastrically, blood alcohol concentration (BAC) peaked at 30 min after alcohol ingestion and reached 1.77 +/- 0.14 mg/ml (mean values +/- SD, n = 6). If daidzin (30 mg/kg) was mixed with the ethanol solution and given to animals intragastrically, BAC was found to peak at 90 min after alcohol ingestion and reached only 1.20 +/- 0.30 mg/ml (n = 6) (p < 0.05 vs. controls). The ability of daidzin to delay and decrease peak BAC level after ethanol ingestion was also observed in fed animals. In both fasted and fed rats given alcohol without daidzin, BAC quickly declined after reaching its peak at 30 min. By contrast, BAC levels receded more slowly if daidzin was also fed to the animals. Daidzin showed a chronic effect. Rats fed daidzin for 7 days before ethanol challenge, but not on the day of challenge, also produced lower and later peak BAC levels. Interestingly, daidzin, whether fed to rats only once or chronically for 7 days, did not significantly alter activities of either alcohol dehydrogenase or mitochondrial aldehyde dehydrogenase in the liver. Further experiments demonstrated that daidzin shortened sleep time for rats receiving ethanol intragastrically (7 g/kg) but not intraperitoneally (2 g/kg). To test whether daidzin delayed stomach-emptying, [14C]polyethylene glycol was mixed with ethanol and fed to rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction <sup>1</sup> (1991)

The lipid A domain of lipopolysaccharide (LPS) is a unique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of most gram-negative bacteria. Because of its profound pharmacological effects on animal cells, especially those of the immune system, lipid A is also known as endotoxin. Despite decades of earlier work, the precise chemistry of endotoxins and the biochemical pathways for their enzymatic synthesis have been elucidated only within the past 5 years. In this review, we summarize the essentials of endotoxin biochemistry and also present recent experiments aimed at identifying surface receptors, signal-transducing elements, transcriptional factors, and key intracellular targets involved in the response of animal cells to endotoxins.
Diffuse large B-cell lymphoma in the elderly (2017)

Okolo 30% chorych na chloniaka rozlanego z duzych limfocytow B (DLBCL) to osoby > 70. roku zycia. Rytuksymab w skojarzeniu z CHOP pozostaje standardową metodą leczenia chorych w wieku podeszlym z wyjątkiem osob z istotnymi schorzeniami wspolistniejącymi. Stosowanie R-CHOP w tej grupie wiąze sie z ryzykiem mielotoksyczności oraz kardiotoksyczności indukowanej doksorubicyną. Istotne dla skuteczności chemioterapii jest leczenie wspomagające m.in. czynnikami stymulującymi granulopoeze (G-CSF). W pracy podsumowano mozliwości optymalizacji leczenia DLBCL u osob w wieku podeszlym.
<i>KCNJ11</i> knockout morula re-engineered by stem cell diploid aggregation (2008)

KCNJ11-encoded Kir6.2 assembles with ATP-binding cassette sulphonylurea receptors to generate ATP-sensitive K+ (KATP) channel complexes. Expressed in tissues with dynamic metabolic flux, these evolutionarily conserved yet structurally and functionally unique heteromultimers serve as high-fidelity rheostats that adjust membrane potential-dependent cell functions to match energetic demand. Genetic defects in channel subunits disrupt the cellular homeostatic response to environmental stress, compromising organ tolerance in the adult. As maladaptation characterizes malignant KATP channelopathies, establishment of platforms to examine progression of KATP channel-dependent adaptive behaviour is warranted. Chimeras provide a powerful tool to assay the contribution of genetic variance to stress intolerance during prenatal or post-natal development. Here, KCNJ11 KATP channel gene knockout<-->wild-type chimeras were engineered through diploid aggregation. Integration of wild-type embryonic stem cells into zona pellucida-denuded morula derived from knockout embryos achieved varying degrees of incorporation of stress-tolerant tissue within the KATP channel-deficient background. Despite the stress-vulnerable phenotype of the knockout, ex vivo derived mosaic blastocysts tolerated intrauterine transfer and implantation, followed by full-term embryonic development in pseudopregnant surrogates to produce live chimeric offspring. The development of adult chimerism from the knockout<-->wild-type mosaic embryo offers thereby a new paradigm to probe the ecogenetic control of the KATP channel-dependent stress response.
Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice. (1997)

Heat-stable enterotoxins (STa), which cause an acute secretory diarrhea, have been suggested to mediate their actions through the guanylyl cyclase-C (GC-C) receptor. The GC-C gene was disrupted by insertion of neo into exon 1 and subsequent homologous recombination. GC-C null mice contained no detectable GC-C protein. Intestine mucosal guanylyl cyclase activity was approximately 16-fold higher in wild-type mice than in the GC-C null mice, and STa-stimulable guanylyl cyclase activity was absent in the null animals. Thus, GC-C is the major cyclase activity present in the intestine, and also completely accounts for the STa-induced elevations of cGMP. Gavage with STa resulted in marked fluid accumulation within the intestine of wild-type and heterozygous suckling mice, but GC-C null animals were resistant. In addition, infection with enterotoxigenic bacteria that produce STa led to diarrhea and death in wild-type and heterozygous mice, while the null mice were protected. Cholera toxin, in contrast, continued to cause diarrhea in GC-C null mice, demonstrating that the cAMP signaling pathway remained intact. Markedly different diets (high carbohydrate, fat, or protein) or the inclusion of high salt (K+, Na+) in the drinking water or diet also did not severely affect the null animals. Given that GC-C is a major intestinal receptor in all mammals, the pressure to retain a functional GC-C in the face of diarrhea-inflicted mortality remains unexplained. Therefore, GC-C likely provides a protective effect against stressors not yet tested, possibly pathogens other than noninvasive enterotoxigenic bacteria.
On capillary instability of jets of magneto‐rheological fluids (1996)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation V. M. Entov, M. Barsoum, L. E. Shmaryan; On capillary instability of jets of magneto‐rheological fluids. J. Rheol. 1 September 1996; 40 (5): 727–739. https://doi.org/10.1122/1.550761 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
Transformer and feeder load balancing using a heuristic search approach (1993)

Heuristic search algorithms based on some heuristic rules are proposed to reach the desired switching operations through which power transformer and distribution feeder load balancing can be achieved. The proposed method can be applied to changing load conditions as well as constant load conditions. The effectiveness of the approach is demonstrated by conducting feeder reconfiguration on a distribution system within the Taipei South District Office of the Taiwan Power Company. It is found that the desired switching operations can be reached in a very efficient manner by using the proposed algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Espacialidad, género y nación. La anti/elegía gay y la función social del discurso funerario en la poesía de guerra de Emilio Prados (2022)

Este trabajo describe un proceso de producción y transformación del espacio bélico y de la nación como formaciones ideológicas asociadas a la masculinidad heteronormativa. El foco principal del argumento es el análisis de la función social del discurso funerario en verso en dos romances de la Guerra Civil de España, originalmente publicados por Emilio Prados en 1937 en el furor de la batalla. Por un lado, el lamento por los camaradas muertos le proporciona a Prados la oportunidad de expresar en el poema el lazo afectivo entre hombres. Por otro lado, Prados introduce en su escritura un subtexto macabro anti-elegíaco asociado al golpe de estado de 1936, y a la resistencia antifascista que por contraposición a la destrucción y la muerte se incorpora a la representación del cuerpo masculino en el poema. En ambos casos, Prados incluye en estos textos un discurso funerario cuyo objetivo transciende la función pública del duelo y se instala en la expresión de la experiencia homoerótica. Una discusión del marco teórico sirve como introducción al argumento general del artículo. Esta sección introduce el concepto de «espacio social» de Henri Lefebvre, la dialéctica socio-espacial de Edward Soja, y la imbricación simbólica del paisaje en el proceso de formación social según explica Denis Cosgrove. Esta introducción viene seguida de unos apuntes con algunos de los aspectos formales del discurso anti/elegíaco sobre los que se asienta el análisis de los textos de Prados.
Rearrangement of the Angular Methyl Group in Dehydroabietic Acid Derivatives. (1993)

The rearrangement of the angular methyl group in dehydroabietic acid derivatives was examined. Treatment of 12-methoxy-5, 8, 11, 13-abietatetraene (25) with boron trifluoride etherate afforded 12-methoxy-5β-methyl-10-norabieta-1(10), 8, 11, 13-tetraene (26). On the other hand, 12-methoxy-7-oxo-5, 8, 11, 13-abietatetraene (27) provided three naphthalene derivatives, 28, 29 and 30, on treatment with sulfuric acid in acetic anhydride. Methyl 7-oxo-5, 8, 11, 13-abietatetraen-18-oate (5) was reduced with sodium borohydride in the presence of cerium(III) chloride heptahydrate and the resulting alcohol (32) was further treated with p-toluensulfonic acid monohydrate to give methyl 5β-methyl-10-norabieta-1(10), 6, 8, 11, 13-pentaen-18-oate (33). On the other hand, under similar conditions, 7-oxo-5, 8, 11, 13-abietatetraene (11) and its 12-methoxy derivative (27) were transformed into the naphthalene derivatives, 35 and 37, respectively, via the corresponding alcohols, 34 and 36.
Error rate performance of experimental gigabit per square inch recording components (1990)

The authors measured the ontrack and offtrack error-rate performance of several combinations of experimental heads and disks using a partial-response channel at approximately 1 Gb/in/sup 2/. The system components include a magnetoresistive head, a thin-film disk, and the partial response readback channel. Precompensation and equalization were used to tune the channel for best performance. Results indicate that these components can write and read data at 1 Gb/in/sup 2/ with good error rates and offtrack margins.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Avian Influenza – The Next Pandemic? (2004)

A vian influenza (AI) strains affecting humans were first reported in Hong Kong during the 1997 influenza season. These strains were shown to be derived from avian sources without genetic reassortment between avian and human influenza viruses (1-3). The first AI A strain (H5N1) affected 18 humans and was associated with six deaths during the 1997 to 1998 influenza season. A case-control study (4) identified recent exposure to live poultry as an important risk factor for infection with H5N1. Furthermore, cohort studies (5,6) suggested that human-to-human transmission of the H5N1 virus was limited. Three additional cases of confirmed H5N1 influenza occurred in Hong Kong in February 2003, causing two deaths (7). From late 2003 to February 2004, outbreaks of H5N1 infection in poultry were detected in a number of Asian countries, notably Vietnam, Thailand, Cambodia, China, Indonesia, Japan, Laos and the Republic of Korea (8). These poultry outbreaks have been unpredictable and unprecedented in their scope, with wide geographical spread and severe economic consequences for the affected countries. More than one-half of the aforementioned countries experienced highly pathogenic AI in fowl for the first time in their respective histories.
Unsupervised state clustering for stochastic dialog management (2007)

Following recent studies in stochastic dialog management, this paper introduces an unsupervised approach aiming at reducing the cost and complexity for the setup of a probabilistic POMDP-based dialog manager. The proposed method is based on a first decoding step deriving semantic basic constituents from user utterances. These isolated units and some relevant context features (as previous system actions, previous user utterances...) are combined to form vectors representing the on-going dialog states. After a clustering step, each partition of this space is intented to represent a particular dialog state. Then any new utterance can be classified according to these automatic states and the belief state can be updated before the POMDP-based dialog manager can take a decision on the best next action to perform. The proposed approach is applied to the French media task (tourist information and hotel booking). The media 10k-utterance training corpus is semantically rich (over 80 basic concepts) and is segmentally annotated in terms of basic concepts. Before user trials can be carried out, some insights on the method effectiveness are obtained by analysis of the convergence of the POMDP models.
Access to 2‐Aminopyridines – Compounds of Great Biological and Chemical Significance (2011)

Abstract 2‐Aminopyridines are key structural cores of bioactive natural products, medicinally important compounds, and organic materials and thus, extremely valuable synthetic targets. The few reported 6‐substituted 2‐aminopyridines and the lack of flexible, efficient and general applicable methods for their synthesis demonstrates the urgent need of new methods for their preparation. Reactions between 2,6‐dibromopyridine and primary or secondary, cyclic or acyclic, and aliphatic or aromatic amines were shown to selectively yield the respective 6‐bromopyridine‐2‐amines in very high yields which were successfully used as substrates for subsequent CC cross‐coupling reactions. The recently introduced dichloro‐bis[1‐(dicyclohexylphosphanyl)piperidine]palladium ( 1 ) was used as catalyst for the cross‐coupling of 6‐bromopyridine‐2‐amines with arylboronic acids, diaryl‐ and dialkylzinc reagents or olefins and hence, is also an excellent CC cross‐coupling catalyst for this type of substrate. Moreover, all the reaction protocols presented were in each of the catalyses uniformly applied. The scope of both the amination and the cross‐coupling reactions are well defined and allow one to simply adapt the reaction protocols directly to other amines and/or coupling partners and, thus, provide for the first time a very flexible and generally applicable reaction protocol to get access to 2‐aminopyridines.
Photosensitivity (2004)

A 30-year-old white woman has a 72-hour history of a pruritic rash on her arms and chest. This is the third episode of the rash this summer, and each episode began in the evening after she had spent less than 30 minutes by a swimming pool in the morning. She has no history of sensitivity to sunlight and is taking no medications. Both the rash and the pruritus are improving, but she still has discomfort. How should this woman be evaluated and treated?
A morphologic study of Venus Ridge belts (1989)

Ridge belts, first identified in the Venera 15/16 images are distinguished as linear regions of concentrated, parallel to anastomosing, ridges. They are tens to several hundreds of km wide, hundreds to over one thousand km long, and composed of individual ridges 5 to 20 km wide and up to 200 km long. The ridges appear symmetrical in the radar images and are either directly adjacent to each other or separated by mottled plains. Cross-strike lineaments, visible as dark or bright lines, are common within the ridge belts, and some truncate individual ridges. In places the ridge belt may be offset by these lineaments, but such offset is rarely consistent across the ridge belt. Once the mode of formation of these ridge belts is understood, their distribution and orientation will help to constrain the homogeneity and orientation of the stresses over the period of ridge belt formation. The look direction for the Venera system was to the west, so ridges appear as pairs of bright and dark lineaments, with the bright line to the east of the dark. The term ridge was used in a general sense to refer to a linear rise. The use of this term is restricted to rises which have a sharp transition from bright to dark at the crest, and are 5 to 15 km wide. These ridges are either continuous or discontinuous. The continuous ridges are over 30 km long and form coherent ridge belts, while the discontinuous ridges are less than 30 km long and do not form a coherent ridge belt. The continuous ridges were divided into 3 components: (1) Anastomosing ridges, in which the individual ridges are sinuous and often meet and cross at small angles, are the most common component; (2) The parallel ridge component also consists of well defined ridges, often with plains separating the individual ridges, but the ridges are more linear and rarely intersect one another; and (3) Parallel ridged plains are composed of indistinct ridges, some of which do not have a distinctive bright-dark pattern. The nature of deformation within the ridge belts is complex and not fully understood at present. Some belts show distinct signs of compression, while others have symmetrical patterns expected in extensional environments. Thus the ridge belts may have formed by more than one style of deformation; some may be extensional, while others are compressional. All the ridge belts are being systematically mapped, especially for symmetrical relationships.
3-Acyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxides. I. Alkylation, amination, and ethoxycarbonylation (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT3-Acyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxides. I. Alkylation, amination, and ethoxycarbonylationC. R. RasmussenCite this: J. Org. Chem. 1974, 39, 11, 1554–1560Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/jo00924a023https://doi.org/10.1021/jo00924a023research-articleACS PublicationsRequest reuse permissionsArticle Views218Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Performance improvement of distributed video coding by using block mode selection (2010)

Block mode selection is one new way to improve the performance of distributed video coding (DVC). Since there are many factors influencing the correctness of the block mode selection, the decision of block mode is not an easy work. In this paper, a low complexity block mode selection model is proposed to select the block modes more correctly in the WZ (Wyner-Ziv) frame. The proposed block mode selection modules can increase the RD performance up to 2.8 dB as compared with the traditional DVC codecs; moreover, the subjective quality can also be improved by using the proposed deblocking filter when the objective quality is kept the same.
Simple Models for the Analysis of Association in Cross-Classifications Having Ordered Categories (1979)

Abstract A class of models is proposed for the analysis of association in a contingency table with ordered rows and ordered columns. Association is measured in terms of the odds-ratios in 2 × 2 subtables formed from adjacent rows and adjacent columns. This class includes the null association model, the uniform association model, and models that describe the possible effects of the rows and/or columns on the association. With these models, the association in the table can be analyzed in a manner analogous to the usual two-way analysis of variance, and parsimonious descriptions of this association can be obtained often. Applications are discussed here, some well-known sets of data are reanalyzed, and new insights into these data are obtained.
Pharmacologic elevation of high-density lipoproteins: recent insights on mechanism of action and atherosclerosis protection (2004)

An understanding of the atheroprotective mechanisms of HDL is essential for the rational use of currently available drugs and directed development of new drugs. Increasing total HDL cholesterol may not be as important as increasing the functional properties of HDL. Cardiovascular disease treatment and prevention can be improved by combining current low-density lipoprotein-based strategies with effective HDL-based interventions.
COMPARATIVE EFFICIENCY OF SPRINKLER IRRIGATION OVER CHECK BASINIRRIGATION IN GROUNDNUT AT DIFFERENT IRRIGATION SCHEDULES (2013)

The field experiments were conducted for consecutive two years to assess the comparative efficiency of sprinkler irrigation over check basin irrigation at different irrigation schedules for groundnut (K-6) during rabi season. Split plot design was adopted for the experiment with two methods of irrigation as main treatments M1 – Sprinkler method and M2 – Check basin irrigation and three irrigation schedules based on IW/CPE ratio at 0.6 (I1), 0.8 (I2) & 1.0 (I3) as sub treatments, replicated thrice. During 2004-05, there was no significant difference in the pod yield obtained between the methods of irrigation, however irrigation scheduled at 1.0 IW/CPE ratio significantly out yielded (1511 kg/ha) the pod yield obtained at 0.8 & 0.6 IW/CPE ratios. The WUE and shelling percent were also not influenced by the irrigation methods and schedules. Significantly higher pod yield was obtained during 2005-06 under sprinkler method of irrigation (2020 kg/ ha) as compared to check basin of irrigation (1762 kg/ha). Irrigation at IW/CPE of 1.0 (I3) resulted in significantly higher pod yield (2123 kg/ha) when compared to I1 and was on par with that of 0.8 IW/CPE ratio (I2). Results indicated that sprinkler method of irrigation scheduled at 1.0 or 0.8 IW/CPE ratios would be beneficial to groundnut crop as compared to check basin method of irrigation.