gebhart/patrepeval huggingface dataset:
Cardiogenesis and the Complex Biology of Regenerative Cardiovascular Medicine (2008)

The heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle cells. Understanding the pathways that drive the formation, migration, and assembly of these cells into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These progenitors must respond to non-cell-autonomous signaling cues to expand, differentiate, and ultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering technologies with patient-specific cardiac progenitor biology holds great promise for the development of human cell models of human disease and may lay the foundation for novel approaches in regenerative cardiovascular medicine.
PIASy Mediates SUMO-2/3 Conjugation of Poly(ADP-ribose) Polymerase 1 (PARP1) on Mitotic Chromosomes (2010)

PIASy is a small ubiquitin-related modifier (SUMO) ligase that modifies chromosomal proteins in mitotic Xenopus egg extracts and plays an essential role in mitotic chromosome segregation. We have isolated a novel SUMO-2/3-modified mitotic chromosomal protein and identified it as poly(ADP-ribose) polymerase 1 (PARP1). PARP1 was robustly conjugated to SUMO-2/3 on mitotic chromosomes but not on interphase chromatin. PIASy promotes SUMOylation of PARP1 both in egg extracts and in vitro reconstituted SUMOylation assays. Through tandem mass spectrometry analysis of mitotically SUMOylated PARP1, we identified a residue within the BRCA1 C-terminal domain of PARP1 (lysine 482) as its primary SUMOylation site. Mutation of this residue significantly reduced PARP1 SUMOylation in egg extracts and enhanced the accumulation of species derived from modification of secondary lysine residues in assays using purified components. SUMOylation of PARP1 did not alter in vitro PARP1 enzyme activity, poly-ADP-ribosylation (PARylation), nor did inhibition of SUMOylation of PARP1 alter the accumulation of PARP1 on mitotic chromosomes, suggesting that SUMOylation regulates neither the intrinsic activity of PARP1 nor its localization. However, loss of SUMOylation increased PARP1-dependent PARylation on isolated chromosomes, indicating SUMOylation controls the capacity of PARP1 to modify other chromatin-associated proteins.
Insect attractants: volatiles of hydrolyzed protein insect baits (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInsect attractants: volatiles of hydrolyzed protein insect baitsRon G. Buttery, Louisa C. Ling, Roy Teranishi, and T. R. MonCite this: J. Agric. Food Chem. 1983, 31, 4, 689–692Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/jf00118a003https://doi.org/10.1021/jf00118a003research-articleACS PublicationsRequest reuse permissionsArticle Views253Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release. (1999)

We investigated the effects of IgE versus IL-4 on Fc epsilon RI surface expression in differentiated human mast cells derived in vitro from umbilical cord blood mononuclear cells. We found that IgE (at 5 micrograms/ml) much more strikingly enhanced surface expression of Fc epsilon RI than did IL-4 (at 0.1-100 ng/ml); similar results were also obtained with differentiated mouse mast cells. However, IL-4 acted synergistically with IgE to enhance Fc epsilon RI expression in these umbilical cord blood-derived human mast cells, as well as in mouse peritoneal mast cells derived from IL-4-/- or IL-4+/+ mice. We also found that: 1) IgE-dependent enhancement of Fc epsilon RI expression was associated with a significantly enhanced ability of these human mast cells to secrete histamine, PGD2, and leukotriene C4 upon subsequent passive sensitization with IgE and challenge with anti-IgE; 2) preincubation with IL-4 enhanced IgE-dependent mediator secretion in these cells even in the absence of significant effects on Fc epsilon RI surface expression; 3) when used together with IgE, IL-4 enhanced IgE-dependent mediator secretion in human mast cells to levels greater than those observed in cells that had been preincubated with IgE alone; and 4) batches of human mast cells generated in vitro from umbilical cord blood cells derived from different donors exhibited differences in the magnitude and pattern of histamine and lipid mediator release in response to anti-IgE challenge, both under baseline conditions and after preincubation with IgE and/or IL-4.
122 GHz aperture-coupled stacked patch microstrip antenna in LTCC technology (2016)

An aperture-coupled stacked patch microstrip antenna based on Low-Temperature Co-fired Ceramic (LTCC) technology is presented in this paper. Inspite of using an antenna substrate with high permittivity of 7.1 and only 200 µm thickness, wide bandwidth characteristic is achieved by means of coupled resonances. The antenna physical features contributing to the coupled resonances include a rectangular aperture, two stacked patches and a double via fence. The influence of various antenna parameters is analyzed in order to optimize the antenna design. The measured antenna reflection coefficient and gain shows good agreement with the simulation results, thus verifying the future potential for integrating this off-chip antenna with a Millimeter-Wave Integrated Circuit (MMIC) placed in an LTCC air cavity, for realization of a 122 GHz fully integrated, low-cost and surface mountable LTCC Antenna-in-Package.
More myths of migration. (1986)

This paper discusses some of the myths of migration. The 5 myths presented are: 1) racism has little to do with the causes of migration and does not necessarily impede the adjustment or success of migrants; 2) in areas where there is a strong feminist movement and trade unions, migrant women receive their support and can count on the solidarity of these organizations; 3) transnational corporations are positive forces in the developing countries where they operate--not only do they provide these states with new sources of capital, but they also impart new industrial skills to the labor force; 4) migration today is essentially short-term in nature--it therefore does not have a strong impact on family life; and 5) most migrants cluster together in ethnic enclaves which provide a strong source of support and diminish dislocation inherent in the migrant process.
A Complementary Resistive Switch-Based Crossbar Array Adder (2015)

Redox-based resistive switching devices (ReRAM) are an emerging class of nonvolatile storage elements suited for nanoscale memory applications. In terms of logic operations, ReRAM devices were suggested to be used as programmable interconnects, large-scale look-up tables or for sequential logic operations. However, without additional selector devices these approaches are not suited for use in large scale nanocrossbar memory arrays, which is the preferred architecture for ReRAM devices due to the minimum area consumption. To overcome this issue for the sequential logic approach, we recently introduced a novel concept, which is suited for passive crossbar arrays using complementary resistive switches (CRSs). CRS cells offer two high resistive storage states, and thus, parasitic “sneak” currents are efficiently avoided. However, until now the CRS-based logic-in-memory approach was only shown to be able to perform basic Boolean logic operations using a single CRS cell. In this paper, we introduce two multi-bit adder schemes using the CRS-based logic-in-memory approach. We proof the concepts by means of SPICE simulations using a dynamical memristive device model of a ReRAM cell. Finally, we show the advantages of our novel adder concept in terms of step count and number of devices in comparison to a recently published adder approach, which applies the conventional ReRAM-based sequential logic concept introduced by Borghetti et al.
DC/DC converters fuzzy control (2002)

This paper aims to illustrate the use of a sophisticated methodology, based on system simulation techniques, to design a fuzzy controller for a DC/DC converter. The goal of the control is to stabilize the voltage output of the switching regulator against the load and parametric variations for a flyback topology. This system is characterized by being unstable in closed loop configuration. Robustness and high performances art requested to the control law especially for high power systems (more than 200 Watt). In order to obtain a good cost/performances ratio, the rules and the related membership functions have to be implemented via an analog dedicated solution capable to obtain an elevated number of FIPS (fuzzy inference per second).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Disability-Rights Based International Cooperation: With Some References to North Korea (2018)

본 논문은 2006년 유엔 장애인권리협약의 맥락에서 사회복지 관점으로부터 인권 및 장애인 권리의 현주소를 탐구하려고 시도하였다. 전반적인 논의는 일반적인 인권과 특히 장애인권의 과제들에 대한 과감한 해결이 어려운 북한의 상황에 초점이 맞춰져 있다. 유엔 장애인 권리협약은 모든 비준 당사국이 협약을 이행하기 위해 법제도의 개혁과 조화, 정책 및 프로그램 개발을 시작하도록 촉구한다. 남북한도 모두 예외가 아니다. 북한 인권에 관해서는 유엔 조사위원회에 의하지 않더라도 그 비참한 상황은 잘 드러나 있다. 그러나 이 논문에서는 한국의 인권이 북한보다 우월하다고 보는 것은 아니다. 이 논문은 그 문제에 대해 남북한과 그밖에 다른 나라들에게 공통된 추가 조치를 위한 영역들을 제시하였다. 장애인 권리에 관한 일반적인 논의와 별개로 본 논문의 특별한 기여는 북한에 관한 최신 정보와 자료를 도출하려고 노력한 사실에 있다. 그것은 유엔과 북한 자체로부터 나온 여러 출처에 의존하였다. 북한 장애인 당국은 장애인의 인권 개선을 위해 외부로부터의 도움을 청하려는 열의로 매우 노력하고 있음을 알 수 있다. 또한 그것은 재정적 지원 및 물질적 지원에 대한 국제적 협력의 많은 필요성을 보여준다. 본 논문은 유엔장애권리협약 제32조가 규정하는 국제협력의 기치 아래, 남북한의 장애인단체간 협력에 긍정적 신호로 평화와 안정을 위한 단계적 조치를 취하는 남북한 간의 최근 정치발전에 주목하고 있다. 보다 비판적으로, 본 논문에서는 균형 잡힌 법제도 개혁, 정책 개발을 보장하며 국제 협력 분야를 선명하게 하기 위해 전반적인 데이터 기반을 개선해야 할 필요성을 지적하였다.This paper attempts to explore the place of human and disability rights from the perspective of Social Welfare within the context of the UN Disability Rights Convention of 2006. The overall discussion is focused especially upon the situations of human and disability rights in the Democratic People s Republic of Korea (North Korea) as it is being challenged to drastically address the issues of human rights in general, and disability rights in particular. The UN Disability Rights Convention challenges every ratified State party to commence legal reforms, legal harmonization, and policy and program developments to implement the Convention. Both North and South Korea are not exceptions to this. Even without drawing upon the UN s the Commission of Inquiry on Human Rights in the Democratic People s Republic of Korea, the dire situation of human rights in North Korea is well documented. However, this paper does not assume South Korea s human rights are any way superior to that of North Korea. This paper spells out areas for further action common to two Koreas and to any other nations for that matter. Apart from the general discussion on disability rights, the distinctive contribution of this paper lies in the fact that it has endeavored to draw upon any latest information and data on North Korea. It relied on various sources from UN and also from North Korea itself. One can note that North Korean disability authorities are making strenuous efforts to improve human rights of persons with disabilities in their desires to seek assistance from outside. It also shows an enormous need for international cooperation in seeking financial and material supports. This paper notes the latest political development between North and South Korea in taking “phased” steps for peace and stability as a positive sign for North and South Koreans DPOs collaboration under the banner of International Cooperation of the article 32 of the UN Disability Rights Convention. More critically, this paper points to the further need to improve the overall data bases to ensure balanced legal reforms, policy developments and sharpen the areas of international collaboration.
Tissue Distribution of the Four Gene Products of the Plasma Membrane Ca2+ Pump (1995)

Antibodies against the four isoforms of the human plasma membrane Ca(2+)-ATPase (PMCA) were raised using an N-terminal sequence of the pump as epitope. The antibodies against PMCA isoforms 1, 2, and 3 were not species-specific, e.g. they also recognized the corresponding proteins in rat, whereas that against the human PMCA isoform 4 failed to do so. The tissue distribution of the four isoforms was estimated by Western blot analysis. Two, PMCA1 and PMCA4, were expressed in all tissues tested (with the exception of the choroid plexus, where the former was not detected). In most tissues the signal from the PMCA1 protein exceeded that of PMCA4, the exception being the erythrocyte. The PMCA2 and PMCA3 proteins were only found in neuronal tissues; the PMCA2 protein was present in high concentrations in the cerebellum and in the cerebral cortex. At variance with previous results on mRNA (e.g. the kidney) no other tissues contained the PMCA2 protein. PMCA3 was the other tissue-specific isoform; in agreement with results in the rat, the protein was found in human neuronal tissues, particularly in the choroid plexus, but was practically absent in all other tissues tested.
Outbreak of plasmid-mediated NDM-1-producing Klebsiella pneumoniae ST105 among neonatal patients in Yunnan, China (2016)

NDM-1 producing strains present in the hospital environment pose a potential risk and the incubator water may act as a diffusion reservoir of NDM-1- producing bacteria. Nosocomial surveillance system should play a more important role in the infection control to limit the spread of these pathogens.
A Comparison of Three-Dimensional Breast Displacement and Breast Comfort During Overground and Treadmill Running (2011)

Comparisons of breast support requirements during overground and treadmill running have yet to be explored. The purpose of this study was to investigate 3D breast displacement and breast comfort during overground and treadmill running. Six female D cup participants had retro-reflective markers placed on the nipples, anterior superior iliac spines and clavicles. Five ProReflex infrared cameras (100 Hz) measured 3D marker displacement in four breast support conditions. For overground running, participants completed 5 running trials (3.1 m/s ± 0.1 m/s) over a 10 m indoor runway; for treadmill running, speed was steadily increased to 3.1 m/s and 5 gait cycles were analyzed. Subjective feedback on breast discomfort was collected using a visual analog scale. Running modality had no significant effect on breast displacement (p > .05). Moderate correlations (r = .45 to .68, p < .05) were found between breast discomfort and displacement. Stride length (m) and frequency (Hz) did not differ (p < .05) between breast support conditions or running modalities. Findings suggest that breast motion studies that examine treadmill running are applicable to overground running.
Wireless Emergency Alerts in arbitrary sized target areas: Mobile location aware emergency notification (2015)

Wireless Emergency Alerts (WEA) is a public safety system that uses broadcast from cell towers to send geographically-targeted alerts and warnings to cell phones. It is one of the dissemination channels for the Integrated Public Alert and Warnings System (IPAWS). WEA typically broadcasts an alert in the cells with at least some portion affected by the emergency event. When the affected area includes only portions of one or more cells, there could be a high proportion of False Positives (people who should not have been notified get the message on their cell phones) and/or False Negatives (people who should have been notified but are not notified). We propose a scheme that uses the mobile devices' knowledge of their own location and the target area described in the cell broadcast message to filter the messages in the cell phone and notify the user only when the mobile device's estimated location is within the target area. We evaluate the new scheme in terms of false negatives and positives, radio resource requirements, and notification latency, and compare it with various other geotargeting schemes. We also discuss mechanisms to communicate the target area information efficiently in the limited bandwidth available in cellular broadcast channel. Finally, we discuss ways for allowing a broader set of contexts to determine whether a user should be notified of a given emergency.
Generation of tree images with no main trunk (1995)

A simple method of generating botanical tree images having no main trunk is described, using the method of generating tree images (shapes) having main trunk which we already published in the former papers in our Memoirs.
Editorial (2007)

This paper introduces a route-selecting order batching model with the S-shape routing method in parallel-aisle order picking (SRSB). Order pickers in a wide-aisle system prefer the S-shape route taking a u-turn at the last aisle to shorten the travel distance. Although u-turns improve operations, they actually increase computational complexity in order batching. Our study defines a route-set for the S-shape routes and composites a best fit route for batches from the predefined S-shape routes while partitioning orders into batches. The large-scale extension of the SRSB obtains near-optimal solutions by the tight lower bound of the by identifying the route-selection based relaxed batching model. A comparison of the heuristics solution and its pairing lower bound shows 3.5–6.8 percent optimal gaps on average in a six-aisle parallel-aisle system over a 200–500 orders time-window, which outperforms an available best large-scale algorithm with a 9.9 percent shorter travel distance on average. Using the identified lower bound, we evaluate other large-scale batching algorithms in the published literature. We find that a popular savings algorithm shows 8.3–19.8 percent optimal gaps over a variety of large-scale simulation cases.
Hedgehog (2014)

Since the discovery of the segment polarity gene Hedgehog in Drosophila three decades ago, our knowledge of Hedgehog signaling pathway has considerably improved and paved the way to a wide field of investigations in the developing and adult central nervous system. Its peculiar transduction mechanism together with its implication in tissue patterning, neural stem cell biology, and neural tissue homeostasis make Hedgehog pathway of interest in a high number of normal or pathological contexts. Consistent with its role during brain development, misregulation of Hedgehog signaling is associated with congenital diseases and tumorigenic processes while its recruitment in damaged neural tissue may be part of the repairing process. This review focuses on the most recent data regarding the Hedgehog pathway in the developing and adult central nervous system and also its relevance as a therapeutic target in brain and spinal cord diseases.
Timing optimization for testable convergent tree adders (2002)

Carry lookahead adders have been, over the years, an integral part of microprocessor architecture. Structures and levels of adders vary depending on the carry output. In this paper, analysis and optimization processes are first performed on a testable convergent tree adder. It is shown that the structure of the tree provides for a high fanout with an imbalanced tree structure which contributes to a racing effect and increases the timing delay of the circuit. The timing optimization is then realized by reducing the maximum fanout of the adder and by balancing the tree circuit. For a 56-b testable tree adder the optimization in 1.2 /spl mu/m CMOS produces a 6.37% increase in speed of the critical path while only losing 2.16% in area. The full testability of the circuit is maintained in the optimized adder design.
The Nucleolar Channel System of Human Endometrium Is Related to Endoplasmic Reticulum and R-Rings (2007)

The nucleolar channel system (NCS) is a well-established ultrastructural hallmark of the postovulation endometrium. Its transient presence has been associated with human fertility. Nevertheless, the biogenesis, composition, and function of these intranuclear membrane cisternae are unknown. Membrane systems with a striking ultrastructural resemblance to the NCS, termed R-rings, are induced in nuclei of tissue culture cells by overexpression of the central repeat domain of the nucleolar protein Nopp140. Here we provide a first molecular characterization of the NCS and compare the biogenesis of these two enigmatic organelles. Like the R-rings, the NCS consists of endoplasmic reticulum harboring the marker glucose-6-phosphatase. R-ring formation initiates at the nuclear envelope, apparently by a calcium-mediated Nopp140-membrane interaction, as supported by the calcium-binding ability of Nopp140, the inhibition of R-ring formation by calcium chelators, and the concentration of Nopp140 and complexed calcium in R-rings. Although biogenesis of the NCS may initiate similarly, the reduced presence of complexed calcium and Nopp140 suggests the involvement of additional factors.
A ORIGEM E O DESENVOLVIMENTO HISTÓRICO DA PRESCRIÇÃO PENAL (2021)

Este trabalho trata sobre a prescricao penal, uma das causas que extinguem a punibilidade e que por consequencia, limita o poder de atuacao do Estado, o chamado jus puniendi, que e a possibilidade do Estado em criar leis penais ou descriminalizar. Demonstra-se tambem o desenvolvimento historico do instituto, o grau de aperfeicoamento que tomou com o Codigo Frances de 1791. Destaca-se que no Brasil a prescricao apareceu pela primeira vez com o Codigo de Processo Criminal de 1832 e que foi inovada com a vigencia do Codigo Penal de 1940, conforme influencia de Nelson Hungria. Deu-se atencao para as alteracoes que ocorreram com as leis 12.234/2010 e 12.650/2012. Cabe destacar que esta obra constitui-se em uma pesquisa bibliografica, com base na doutrina penalista, processualista e constitucionalista brasileiras, com exposicoes analiticas da origem e desenvolvimento da prescricao, envolvendo seus aspectos historicos e as alteracoes legislativas realizadas neste instituto.
Effective method for the isolation of non-nodulating mutants of<i>Rhizobium trifolii</i> (1978)

SUMMARY Non-nodulating mutants of Rhizobium trifolii were found in cultures incubated at 35 °C for 7 days. From among ten strains incubated at the elevated temperature six became non-nodulating. The frequency of Nod − mutants in R. trifolii cultures varied from 1 to 75% depending on the strain tested. It is suggested that gene(s) controlling nodulation are located on a large plasmid.