gebhart/patrepeval huggingface dataset:
Boosting Performance of Low Temperature Fuel Cell Catalysts by Subtle Ionic Liquid Modification (2015)

High cost and poor stability of the oxygen reduction reaction (ORR) electrocatalysts are the major barriers for broad-based application of polymer electrolyte membrane fuel cells. Here we report a facile and scalable approach to improve Pt/C catalysts for ORR, by modification with small amounts of hydrophobic ionic liquid (IL). The ORR performance of these IL-modified catalysts can be readily manipulated by varying the degree of IL filling, leading to a 3.4 times increase in activity. Besides, the IL-modified catalysts exhibit substantially enhanced stability relative to Pt/C. The enhanced performance is attributed to the optimized microenvironment at the interface of Pt and electrolyte, where advantages stemming from an increased number of free sites, higher oxygen concentration in the IL and electrostatic stabilization of the nanoparticles develop fully, at the same time that the drawback of mass transfer limitation remains suppressed. These findings open a new avenue for catalyst optimization for next-generation fuel cells.
A Reversibly Sealed, Easy Access, Modular (SEAM) Microfluidic Architecture to Establish In Vitro Tissue Interfaces (2016)

Microfluidic barrier tissue models have emerged as advanced in vitro tools to explore interactions with external stimuli such as drug candidates, pathogens, or toxins. However, the procedures required to establish and maintain these systems can be challenging to implement for end users, particularly those without significant in-house engineering expertise. Here we present a module-based approach that provides an easy-to-use workflow to establish, maintain, and analyze microscale tissue constructs. Our approach begins with a removable culture insert that is magnetically coupled, decoupled, and transferred between standalone, prefabricated microfluidic modules for simplified cell seeding, culture, and downstream analysis. The modular approach allows several options for perfusion including standard syringe pumps or integration with a self-contained gravity-fed module for simple cell maintenance. As proof of concept, we establish a culture of primary human microvascular endothelial cells (HMVEC) and report combined surface protein imaging and gene expression after controlled apical stimulation with the bacterial endotoxin lipopolysaccharide (LPS). We also demonstrate the feasibility of incorporating hydrated biomaterial interfaces into the microfluidic architecture by integrating an ultra-thin (< 1 μm), self-assembled hyaluronic acid/peptide amphiphile culture membrane with brain-specific Young's modulus (~ 1kPa). To highlight the importance of including biomimetic interfaces into microscale models we report multi-tiered readouts from primary rat cortical cells cultured on the self-assembled membrane and compare a panel of mRNA targets with primary brain tissue signatures. We anticipate that the modular approach and simplified operational workflows presented here will enable a wide range of research groups to incorporate microfluidic barrier tissue models into their work.
Two-Stage Compact Wideband Flat Gain Low-Noise Amplifier Using High-Frequency Feedforward Active Inductor (2019)

In this article, a wideband differential low-noise amplifier (LNA) for multiband wireless communication applications is proposed. First, shunt peaking is implemented with a self-biased active inductor (AI) to realize wideband characteristics in a compact size. Second, a cross-coupled capacitor is added to the AI, thus constructing a feedforward path. It adds a signal to the output node so that the bandwidth (BW) can be further increased by compensating the gain reduction according to the frequency. Additionally, the feedforward path creates another feedback loop, generating a negative capacitance. The negative capacitance can cancel parasitic capacitance to increase BW with a cascade amplifier. The prototype LNA is fabricated with a 65-nm CMOS process. It has a gain of 26.7 dB and a BW of 4.1 GHz. The noise figure (NF) is 3 dB and the third-order input intercept point (IIP3) is -14.2 dBm at 2 GHz. It consumes 13.9 mA at a 1-V supply and has an area of 0.009 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Influence of preparation methods on the structures and properties for the blends between polyamide 6<i>co</i>6T and polyamide 6: Melt‐mixing and <i>in‐situ</i> blending (2007)

Abstract Two blends between polyamide 6 (PA6) and Polyamide 6 co 6T (PA6 co 6T, a random copolymer between polyamide 6 and polyamide 6T) were fabricated by melt‐mixing on a twin‐screw extruder and the subsequent injection molding, or through the in‐situ polymerization of ε ‐caprolactam in the presence of PA6 co 6T. As far as the former method is concerned, there exist an obvious decline of toughness and a slight increase in strength and modulus; however, for the latter, there appear a remarkable improvement in toughness and a simultaneous moderate increase in strength and modulus. A series of characterizations were carried out including scanning electron microscopy, wide‐angle X‐ray diffraction, polarized optical microscopy, differential scanning calorimetry, dynamic mechanical analysis, and Fourier transform infrared spectrometry. It is found that both blends exhibit single glass transition on DMA tan δ curves. However, contrary to that of the melt‐mixed blends, the glass transition temperature ( T g ) of the in‐situ ones decreases with increasing PA6 co 6T content. It is suggested that different mixing levels are the main reasons. Moreover, the addition of PA6 co 6T containing linear rigid segments conducts remarkable refinement of spherulites for the blends. Significantly different changes in the crystallographic form, spherulite size, crystalline content and perfection due to the introduction of PA6 co 6T for the two blends are ascribed to their varied thermomechanical histories and the presence of interchange reaction only for the in‐situ blends. On the basis of the characterizations of the microstructures, the different trends of changes in the mechanical properties with the addition of PA6 co 6T for the two fabrication methods are discussed. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 201–211, 2008
OpenWSN: a standards‐based low‐power wireless development environment (2012)

ABSTRACT The OpenWSN project is an open‐source implementation of a fully standards‐based protocol stack for capillary networks, rooted in the new IEEE802.15.4e Time Synchronized Channel Hopping standard. IEEE802.15.4e, coupled with Internet of Things standards, such as 6LoWPAN, RPL and CoAP, enables ultra‐low‐power and highly reliable mesh networks, which are fully integrated into the Internet. The resulting protocol stack will be cornerstone to the upcoming machine‐to‐machine revolution. This article gives an overview of the protocol stack, as well as key integration details and the platforms and tools developed around it. The pure‐C OpenWSN stack was ported to four off‐the‐shelf platforms representative of hardware currently used, from older 16‐bit microcontroller to state‐of‐the‐art 32‐bit Cortex‐M architectures. The tools developed around the low‐power mesh networks include visualisation and debugging software, a simulator to mimic OpenWSN networks on a PC, and the environment needed to connect those networks to the Internet. Experimental results presented in this article include a network where motes operate at an average radio duty cycle well below 0.1% and an average current draw of 68 μA on off‐the‐shelf hardware. These ultra‐low‐power requirements enable a range of applications, with motes perpetually powered by micro‐scavenging devices. OpenWSN is, to the best of our knowledge, the first open‐source implementation of the IEEE802.15.4e standard. Copyright © 2012 John Wiley & Sons, Ltd.
Isolation of Functional Subsets of Human Peripheral Blood Monocytes (1979)

Monocytes were isolated by counterflow centrifugation of Ficoll-Hypaque separated peripheral blood mononuclear cells. The monocytes formed a bimodal volume distribution of "large" and "small" phagocytic esterase-positive, peroxidase-positive cells with peaks at 470 and 410 mu3, respectively. The large monocytes were predominately Fc receptor positive, and were able to lyse both sensitized human and chicken erythrocyte targets in ADCC assays, whereas the small monocytes were largely FcR negative and were inactive against sensitized human erythrocyte targets. However, ADCC against chicken erythrocyte targets was seen in some fractions containing small monocytes and was probably due to FcR+ lymphocytes (K cells) in those fractions. These experiments establish that monocytes are effectors of ADCC against both human and chicken erythrocyte targets and that the peripheral blood monocyte is heterogeneous in size, function, and surface receptor distribution.
A broadband polarization-insensitive circuit analog absorber using lumped resistors (2015)

In this paper, a broadband circuit analog absorber has been presented based on lumped resistors, which exhibits 10 dB absorption bandwidth from 3.96 GHz to 8.16 GHz, covering entire C-band. The designed structure is polarization-insensitive and wide-angle absorptive. The effect of the lumped resistors has been studied to examine the absorption mechanism of the wideband absorber. The structure has also been fabricated, whose measured results are in good agreement with the simulated responses.
Multiple isoforms of <i>Pisum</i> trypsin inhibitors result from modification of two primary gene products (1995)

Characterization of Pisum (pea) seed trypsin inhibitors (TI) and their corresponding cDNAs indicates that the pea TI gene family contains two genes. The existence of multiple TI isoforms can be attributed to post-translational modifications of primary gene products. Post-translational processing at the C-terminus during the desiccation stage of seed development results in the appearance of TI isoforms with increased affinity for the target enzyme, trypsin.
Eicosapentaenoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/Ta mice: Involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylation (2005)

EPA ameliorates diabetic nephropathy of type 2 diabetic KKAy/Ta mice. We propose that the observed down-regulation of MCP-1 is critically involved in the beneficial effect of EPA, probably in concert with improvement of other clinical parameters.
Performance evaluation of trellis-coded modulation schemes (1994)

A description of the algorithms to evaluate the main parameters determining the performance of a trellis-coded modulation (TCM) scheme is presented. TCM schemes are divided into classes that have an increasing degree of symmetry, so as to properly match the various algorithms to each class. The algorithms are compared in terms of computational complexity and tested on a set of multidimensional PSK codes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A comprehensive review of Thermoelectric Generators: Technologies and common applications (2019)

Power costs increasing, environmental pollution and global warming are issues that we are dealing with in the present time. To reduce their effects, scientists are focusing on improving energy harvesting-based power generators. Thermoelectric generators (TEGs) have demonstrated their ability to directly convert thermal energy into an electrical one via the Seebeck effect. Also, they are environmentally friendly because they do not contain chemical products, they operate silently because they do not have mechanical structures and/or moving parts, and they can be fabricated on many types of substrates like silicon, polymers, and ceramics. Furthermore, TEGs are position-independent, present a long operating lifetime and are suitable for integration into bulk and flexible devices. This paper presents in-depth analysis of TEGs, starting by an extensive description of their working principle, types (planar, vertical and mixed), used materials, figure of merit, improvement techniques including different thermoelectric materials arrangement (conventional, segmented and cascaded), and used technologies and substrates types (silicon, ceramics and polymers). This manuscript also describes the exploitation of TEGs in various fields starting from low-power applications (medical and wearable devices, IoT: internet of things, and WSN: wireless sensor network) to high-power applications (industrial electronics, automotive engines, and aerospace).
Masking failures of multidimensional sensors (2002)

A methodology for transforming a process control program that cannot tolerate sensor failure into one that can is presented. In this methodology, a reliable abstract sensor is created by combining information from several real sensors that measure the same physical value. To be useful, an abstract sensor must deliver reasonably accurate information at reasonable computational cost. The authors consider sensors that deliver multidimensional values (e.g. location or velocity in three dimensions). Geometric techniques are used to derive upper bounds on abstract sensor accuracy and to develop efficient algorithms for implementing abstract sensors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Exact Algorithm for Minimising the Number of Setups in the One-Dimensional Cutting Stock Problem (2000)

The cutting stock problem is that of finding a cutting of stock material to meet demands for small pieces of prescribed dimensions while minimising the amount of waste. Because changing over from one cutting pattern to another involves significant setups, an auxiliary problem is to minimise the number of different patterns that are used. The pattern minimisation problem is significantly more complex, but it is of great practical importance. In this paper, we propose an integer programming formulation for the problem that involves an exponential number of binary variables and associated columns, each of which corresponds to selecting a fixed number of copies of a specific cutting pattern. The integer program is solved using a column generation approach where the subproblem is a nonlinear integer program that can be decomposed into multiple bounded integer knapsack problems. At each node of the branch-and-bound tree, the linear programming relaxation of our formulation is made tighter by adding super-additive inequalities. Branching rules are presented that yield a balanced tree. Incumbent solutions are obtained using a rounding heuristic. The resulting branch-and-price-and-cut procedure is used to produce optimal or approximately optimal solutions for a set of real-life problems.
Minimal residual disease quantification using consensus primers and high-throughput IGH sequencing predicts post-transplant relapse in chronic lymphocytic leukemia (2013)

Quantification of minimal residual disease (MRD) following allogeneic hematopoietic cell transplantation (allo-HCT) predicts post-transplant relapse in patients with chronic lymphocytic leukemia (CLL). We utilized an MRD-quantification method that amplifies immunoglobulin heavy chain (IGH) loci using consensus V and J segment primers followed by high-throughput sequencing (HTS), enabling quantification with a detection limit of one CLL cell per million mononuclear cells. Using this IGH-HTS approach, we analyzed MRD patterns in over 400 samples from 40 CLL patients who underwent reduced-intensity allo-HCT. Nine patients relapsed within 12 months post-HCT. Of the 31 patients in remission at 12 months post-HCT, disease-free survival was 86% in patients with MRD <10(-4) and 20% in those with MRD ≥10(-4) (relapse hazard ratio (HR) 9.0; 95% confidence interval (CI) 2.5-32; P<0.0001), with median follow-up of 36 months. Additionally, MRD predicted relapse at other time points, including 9, 18 and 24 months post-HCT. MRD doubling time <12 months with disease burden ≥10(-5) was associated with relapse within 12 months of MRD assessment in 50% of patients, and within 24 months in 90% of patients. This IGH-HTS method may facilitate routine MRD quantification in clinical trials.
Cerebrovascular Disease: Research and Clinical Management Vol 1 (1987)

To those of us who believe that there is a biological basis to psychiatric illness, the search for biochemical abnormalities in brain would seem a logical approach.The study of the monoamines, particularly dopamine, noradrenaline and 5HT, has received considerable attention.The appar- ent involvement of these transmitter substances in psychoses and depression has greatly assisted the development of drug treatment.More latterly, the involvement of GABA in anxiety has had a similar effect and there are hopes that involvement of
Infectious diarrhoea in children: Controlling transmission in the child care setting (1994)

An increase in the number of preschool children cared for within groups in child care centres has been associated with increasing numbers of women in the workforce. Children at this age are at high risk for gastrointestinal diseases caused by a large number of enteric pathogens, and the risk is increased by the greater potential for person-to-person transmission within group care. This report considers the pathogens that may cause diarrhoeal illness in children, with particular reference to those that have been reported in formal day care settings. The major risk factors for transmission of these agents and a high rate of diarrhoeal illness in the child care setting include attendance of non-toilet-trained children, staff combining nappy changing and food preparation duties, large enrollment, low staff-to-child ratio, and poor hygiene and child handling practices. Investigations undertaken during an outbreak of diarrhoea have frequently used limited diagnostic testing, often suitable for identifying only bacterial and protozoal agents. Such limited investigations have tended to incriminate agents that have prolonged carriage and are easily identifiable in standard microbiology laboratories. Finding a pathogen in these circumstances needs to be interpreted with caution. Prevention and control measures include training and education in good personal hygiene, emphasis on the need for frequent handwashing, separation of change areas from food handling and eating areas, routine cleaning and disinfection of environmental surfaces and personal items, and exclusion of any child or child care worker with diarrhoea.
Requirement for an Additional Divalent Metal Cation To Activate Protein Tyrosine Kinases (1997)

In addition to the magnesium ion needed to form the true phosphate-donating substrate (ATP-Mg complex), we have determined that at least one additional Mg2+ ion is essential for the activation of protein tyrosine kinases. This activation was investigated in detail using purified Csk, Src, and the fibroblast growth factor receptor kinase, which led to the following conclusions. (1) The catalytic activity of these kinases is dependent on the Mg2+ concentration present in the assay, approaching saturation at 5-8 mM MgCl2, while ATP was saturated at approximately 1 mM MgCl2. (2) Extrapolation to zero free Mg2+ at a constant ATP-Mg concentration predicts zero activity, suggesting that free magnesium ion in excess of that needed to bind to ATP is essential for the activation of these enzymes. (3) The free magnesium ion activates Csk and Src kinase activity by increasing the Vmax but does not change their apparent Km(ATP-Mg). In contrast, the free magnesium ion activates the fibroblast growth factor receptor kinase activity by increasing its Vmax and decreasing its apparent Km(ATP-Mg). These and previous studies with the insulin receptor tyrosine kinase suggest that receptor-type protein tyrosine kinases respond to the concentration of free Mg2+ differently than soluble protein tyrosine kinases. (4) With the phosphate-accepting substrate as the variable ligand, increases in the concentration of free Mg2+ resulted in increases in the apparent Vmax for all tyrosine kinases examined, but the apparent Km response is dependent on the enzyme and the substrate used. While these studies do not pinpoint a single kinetic mechanism, they do suggest that additional magnesium ion(s) is(are) an essential activator for protein tyrosine kinases in addition to being a part of the ATP-Mg complex. The difference among protein tyrosine kinases in their kinetic response to the additional divalent metal cation and the potential biological significance of such are discussed.
Model Reference Adaptive Control for Hybrid Electric Vehicle With Dual Clutch Transmission Configurations (2017)

This paper proposes the use of an adaptive control of a hybrid electric vehicle with dual clutch transmission (HDCT). First, this paper shows mathematical equations for the nonlinear system. Then it presents the linearized model for the proposed system. The control objective of the model reference adaptive controller (MRAC) considered in this paper is to minimize fuel consumption and reduce torque interruption in a hybrid electric vehicle. The MRAC can be used to control the electric motor during changes in speed and gear, and the system can adapt to a model that simulates different driver patterns. The effects of using different model responses as input combinations are analyzed in an effort to exploit the over-actuation feature of the system, as is the sensitivity of the performance to various design factors. The simulation results for an HDCT demonstrate that the MRAC achieves reduced torque interruption and less vehicle jerk compared to the conventional method of operation.
Experiments on the difference between semantic similarity and relatedness (2009)

Proceedings of the 17th Nordic Conference of Computational Linguistics\nNODALIDA 2009.\nEditors: Kristiina Jokinen and Eckhard Bick.\nNEALT Proceedings Series, Vol. 4 (2009), 81-88.\n© 2009 The editors and contributors.\nPublished by\nNorthern European Association for Language\nTechnology (NEALT)\nhttp://omilia.uio.no/nealt .\nElectronically published at\nTartu University Library (Estonia)\nhttp://hdl.handle.net/10062/9206 .
The Study of Adsorption of Hydrogen on Zeolites (2010)

Microporous zeolites as media for hydrogen storage have been paid more and more attention in recent years. However, the reports on hydrogen adsorption mechanism, hydrogen storage capacity of the materials and its relevant factors are quite controversial. In this review, the results of adsorption experiments as well as theoretical modeling for hydrogen storage of various structure-type zeolites are briefly reviewed. The influence of many factors on hydrogen storage capacity is emphatically analyzed, such as the zeolitic structures, Si/Al ratio, type of cations in zeolites and the difference of adsorption experimental conditions, etc. And the progress of supercritical adsorption theory models also is discussed. Finally, the possibility and the research trend of zeolites for hydrogen storage are discussed.
Prevention of Infectious Complications in Surgical Patients: Potential Role of Probiotics (2005)

Infectious complications in surgical patients often originate from the intestinal microflora. In the critically ill patient, small bowel motility is disturbed, leading to bacterial overgrowth and subsequent bacterial translocation due to dysfunction of the gut mucosal barrier. The optimal prophylactic strategy should act on all these factors, but such a strategy is not yet available. For several decades, antibiotic prophylaxis to prevent translocation of pathogenic bacteria has been studied with conflicting results. Selective decontamination of the digestive tract has shown good results, but fear for bacterial multiresistance has prevented worldwide implementation. In recent years, probiotics, living bacteria with a potential beneficial effect to their host, have shown promising results in several randomized placebo-controlled trials. Currently, in vitro and experimental research focuses on the effects of probiotics on the microflora responsible for gut-derived infections, structural mucosal barrier function and the immune system.