gebhart/patrepeval huggingface dataset:
Interfacing MXene Flakes on a Magnetic Fiber Network as a Stretchable, Flexible, Electromagnetic Shielding Fabric (2021)

A unique self-standing membrane composed of hierarchical thermoplastic polyurethane (TPU)/polyacrylonitrile (PAN) fibers is prepared by the electrospinning technique, followed by a simple dip-coating process. Fe<sub>3</sub>O<sub>4</sub> nanoparticles are uniformly anchored on TPU/PAN fibers during the electrospinning process, enabling the membrane to achieve effective electromagnetic interference shielding (EMI SE) performance. Such a hybrid membrane has a high magnetization of 18.9 emu/g. When MXene (Ti<sub>3</sub>C<sub>2</sub>T<i><sub>x</sub></i>) layers are further loaded on the TPU/PAN/Fe<sub>3</sub>O<sub>4</sub>NPs hybrid membrane, its EMI SE performance in the X band can exceed 30 dB due to the hydrogen bonds generated between the macromolecular chain of PAN and the functional group (T<i><sub>x</sub></i>) on the surface of MXene. Simultaneously, the interfacial attraction between MXene and the TPU/PAN/Fe<sub>3</sub>O<sub>4</sub>NPs substrate is enhanced. The EMI SE mechanism of the hybrid membrane indicates that this film has great potential in the fields of wearable devices and flexible materials.
Rapid Detection of Norovirus from Fecal Specimens by Real-Time Reverse Transcription-Loop-Mediated Isothermal Amplification Assay (2006)

In this study, we developed a one-step, single-tube genogroup-specific reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of norovirus (NoV) genomes targeting from the C terminus of the RNA-dependent RNA polymerase gene to the capsid N-terminal/shell domain region. This is the first report on the development of an RT-LAMP assay for the detection of NoV genomes. Because of the diversity of NoV genotypes, we used 9 and 13 specially designed primers containing mixed bases for genogroup I (GI) and II (GII), respectively. The RT-LAMP assay had the advantages of rapidity, simplicity, specificity, and selectively and could obtain results within 90 min, generally even within 60 min, under isothermal conditions at 62 degrees C. The detection limits for NoV genomes were between 10(2) and 10(3) copies/tube for GI and GII with differentiation by genotype, and no cross-reactions among NoV GI and GII and other gastroenteritis viruses, such as sapovirus, human astrovirus, adenovirus type 40 and 41, and group A and C rotavirus, were found. In the evaluation tests with fecal specimens obtained from gastroenteritis outbreaks, the sensitivity and specificity of the RT-LAMP assay with regard to RT-PCR were 100 and 94% for GI and 100 and 100% for GII, respectively. These findings establish that the RT-LAMP assay is potentially useful for the rapid detection of NoV genomes from fecal specimens in outbreaks of food-borne and person-to-person-transmitted gastroenteritis.
Characterization of Growth Factor-induced Serine Phosphorylation of Tumor Necrosis Factor-α Converting Enzyme and of an Alternatively Translated Polypeptide (2003)

Tumor necrosis factor-alpha converting enzyme (TACE) is a prototype member of the adamalysin family of transmembrane metalloproteases that effects ectodomain cleavage and release of many transmembrane proteins, including transforming growth factor-alpha. Growth factors that act through tyrosine kinase receptors, as well as other stimuli, induce shedding through activation of the Erk mitogen-activated protein (MAP) kinase pathway without the need of new protein synthesis. How MAP kinase regulates shedding by TACE is not known. We now report that the cytoplasmic domain of TACE is phosphorylated in response to growth factor stimulation. We also identified a naturally expressed smaller polypeptide corresponding to most of the cytoplasmic domain of TACE. This protein, which we named SPRACT, is derived through alternative translation of the TACE-coding sequence and is, similarly to TACE, phosphorylated in response to growth factor and phorbol 12-myristate 13-acetate stimulation. Phosphoamino acid analysis revealed that growth factor-induced phosphorylation of TACE occurs only on serine and not on threonine or tyrosine. Tryptic mapping experiments coupled with site-directed mutagenesis identified Ser(819) as the major target of growth factor-induced phosphorylation, whereas Ser(791) undergoes dephosphorylation in response to growth factor stimulation. The phosphorylation of Ser(819), but not the dephosphorylation of Ser(791), depends on activation of the Erk MAP kinase pathway. Increased SPRACT expression or mutation of the TACE cytoplasmic domain to inactivate growth factor-induced phosphorylation did not detectably affect growth factor-induced shedding of transmembrane transforming growth factor-alpha by TACE. The roles of SPRACT and the cytoplasmic phosphorylation of TACE remain to be defined.
Improved determination of spin density, T<sub>1</sub>and T<sub>2</sub>from a three-parameter fit to multiple-delay-multiple-echo (MDME) NMR images (1986)

A method is presented for simultaneously determining values of relative hydrogen spin density Nr, T1 and T2 from a single set of NMR image intensities acquired in a short imaging time. Present methods use separate acquisitions and data sets to determine all three parameters. In the method presented, multiple-echo data are collected at multiple delays in virtually the same imaging time used to obtain T1 and a T2-weighted Nr from a separate saturation recovery (SR) T1 measurement. All three parameters are then determined by a three-parameter fit of a derived signal intensity equation to these multiple-delay-multiple-echo (MDME) data. This provides an inherent correction of Nr for T1 and T2 weighting without the use of sequences with TD greater than 5T1, and without further data collection for a separate T2 measurement. It also provides an effective reduction in the noise of the separate T2 measurement. A three-parameter fit to MDME data appears to be superior to the separate T1 and T2 measurements currently used to determine all three parameters. Calculations performed on CrCl3 solutions produced T1 values from 21 ms to 3.4 s, T2 values from 6 to 714 ms, and standard errors as low as 0.33%, with a net imaging time of the order of that required for routine low-noise signal intensity imaging. The method could potentially be used in NMR spectroscopy to give similar benefits.
Oxygen's role in alkanolamine degradation (1998)

A new study shows the adverse effects and gives recommendations for identifying and avoiding this problem
On the role of AtDMC1, AtRAD51 and its paralogs during Arabidopsis meiosis (2014)

Meiotic recombination plays a critical role in achieving accurate chromosome segregation and increasing genetic diversity. Many studies, mostly in yeast, have provided important insights into the coordination and interplay between the proteins involved in the homologous recombination pathway, especially the recombinase RAD51 and the meiosis-specific DMC1. Here we summarize the current progresses on the function of both recombinases and the CX3 complex encoded by AtRAD51 paralogs, in the plant model species Arabidopsis thaliana. Similarities and differences respect to the function of these proteins in other organisms are also indicated.
Macro Markets and Financial Security (1999)

Uncertainty about national income growth poses significant macroeconomic risk to households all over the world. To help reduce investors' exposure, researchers have proposed a controversial new set of security markets called macro markets. These international markets would trade long-term claims on the income of an entire country or region. For example, in a macro market for the United States, an investor could buy a claim on the U.S. national income and then receive dividends equal to a fraction of national income for as long as the claim is held. Although many barriers stand in the way of the markets' development - including investors' focus on short-term portfolio performance, sizable startup costs, and contract enforcement difficulties - the potential benefits of these markets are great.
A 40-Gb/s, 850-nm, VCSEL-Based Full Optical Link (2012)

We report a complete VCSEL optical link operating at 40-Gb/s (BER<10−12) with an eye opening of 0.56 UI and 6 dB of link margin. Transmitter pre-distortion enables substantial improvements in speed, jitter, and link margin.
A cross-corner effect in a rectangular sputtering magnetron (2003)

Electron trajectories, ionization distribution, and magnetic field in a conventional rectangular sputtering magnetron cathode are simulated in order to understand the mechanism of a cross-corner effect, which is a common phenomenon associated with rectangular magnetron cathodes and which limits the target utilization. It is found that once the magnetic field in end region of the cathode is different from that in straightway, the cross-corner effect exists. Using a fourth-order Runge–Kutta method, the electron trajectories are simulated, showing that the electrons may drift much faster in the end region than in the straightway and pass quickly to cross-corner region. A Monte-Carlo method is employed to simulate ionization distribution and to quantitatively predict target erosion. The results show denser ionization in the cross-corner region, causing more intensive erosion in that area. We demonstrate that by properly modifying the magnet field in the end region, the electron drift velocity and ionization distribution can be controlled and the cross-corner effect may be significantly reduced.
Morphological fluctuation and electrical properties of sputtered hydrogenated silicon (1982)

Electrical properties and x-ray small angle scattering have been measured on rf-sputtered Si:H alloys deposited at various hydrogen partial pressures of argon and hydrogen mixture gas with a constant total pressure. When the hydrogen partial pressure exceeds 40%, microcrystalline zone of about 200 Å in diameter is formed and photoexcited carriers show nondispersive transport, instead of dispersive transport which is typical of rf-sputtered a-Si:H.
The Newborn With Hearing Loss: Detection in the Nursery (1998)

Screening in the nursery with low false-positive rates can be achieved when three elements are present: audiology involvement, hospital support, and automated data and information management. Follow-up measures need improvement. Better tracking methods may help assure that at-risk newborns are connected to services.
Origami-inspired active structures: a synthesis and review (2014)

Origami, the ancient art of paper folding, has inspired the design of engineering devices and structures for decades. The underlying principles of origami are very general, which has led to applications ranging from cardboard containers to deployable space structures. More recently, researchers have become interested in the use of active materials (i.e., those that convert various forms of energy into mechanical work) to effect the desired folding behavior. When used in a suitable geometry, active materials allow engineers to create self-folding structures. Such structures are capable of performing folding and/or unfolding operations without being kinematically manipulated by external forces or moments. This is advantageous for many applications including space systems, underwater robotics, small scale devices, and self-assembling systems. This article is a survey and analysis of prior work on active self-folding structures as well as methods and tools available for the design of folding structures in general and self-folding structures in particular. The goal is to provide researchers and practitioners with a systematic view of the state-of-the-art in this important and evolving area. Unifying structural principles for active self-folding structures are identified and used as a basis for a quantitative and qualitative comparison of numerous classes of active materials. Design considerations specific to folded structures are examined, including the issues of crease pattern identification and fold kinematics. Although few tools have been created with active materials in mind, many of them are useful in the overall design process for active self-folding structures. Finally, the article concludes with a discussion of open questions for the field of origami-inspired engineering.
Lupeol Suppresses Cisplatin-Induced Nuclear Factor-κB Activation in Head and Neck Squamous Cell Carcinoma and Inhibits Local Invasion and Nodal Metastasis in an Orthotopic Nude Mouse Model (2007)

A poor prognosis in head and neck squamous cell carcinoma (HNSCC) patients is commonly associated with the presence of regional metastasis. Cisplatin-based chemotherapy concurrent with radiation therapy is commonly used in the treatment of locally advanced HNSCC. However, the result is dismal due to common acquisition of chemoresistance and radioresistance. Epidemiologic studies have shown the importance of dietary substances in the prevention of HNSCC. Here, we found that lupeol, a triterpene found in fruits and vegetables, selectively induced substantial HNSCC cell death but exhibited only a minimal effect on a normal tongue fibroblast cell line in vitro. Down-regulation of NF-kappaB was identified as the major mechanism of the anticancer properties of lupeol against HNSCC. Lupeol alone was not only found to suppress tumor growth but also to impair HNSCC cell invasion by reversal of the NF-kappaB-dependent epithelial-to-mesenchymal transition. Lupeol exerted a synergistic effect with cisplatin, resulting in chemosensitization of HNSCC cell lines with high NF-kappaB activity in vitro. In in vivo studies, using an orthotopic metastatic nude mouse model of oral tongue squamous cell carcinoma, lupeol at a dose of 2 mg/animal dramatically decreased tumor volume and suppressed local metastasis, which was more effective than cisplatin alone. Lupeol exerted a significant synergistic cytotoxic effect when combined with low-dose cisplatin without side effects. Our results suggest that lupeol may be an effective agent either alone or in combination for treatment of advanced tumors.
A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers (2016)

The azanucleosides azacitidine and decitabine are currently used for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in patients not only eligible for intensive chemotherapy but are also being explored in other hematologic and solid cancers. Based on their capacity to interfere with the DNA methylation machinery, these drugs are also referred to as hypomethylating agents (HMAs). As DNA methylation contributes to epigenetic regulation, azanucleosides are further considered to be among the first true "epigenetic drugs" that have reached clinical application. However, intriguing new evidence suggests that DNA hypomethylation is not the only mechanism of action for these drugs. This review summarizes the experience from more than 10 years of clinical practice with azanucleosides and discusses their molecular actions, including several not related to DNA methylation. A particular focus is placed on possible causes of primary and acquired resistances to azanucleoside treatment. We highlight current limitations for the success and durability of azanucleoside-based therapy and illustrate that a better understanding of the molecular determinants of drug response holds great potential to overcome resistance.
Balboa: A Framework for Event-Based Process Data Analysis (1998)

Software process research has su#ered from a lack of focussed data analysis techniques and tools. Part of the problem is the ad hoc and heterogeneous nature of the data, as well as the methods of collecting those data. While collection methods must be specific to their data source, analysis tools should be shielded from specific data formats and idiosyncrasies. We have built Balboa as a bridge between the data collection and the analysis tools, facilitating the gathering and management of event data, and simplifying the construction of tools to analyze the data. Balboa is a framework that provides to collection methods a flexible data registration mechanism, and provides to tools a consistent set of data manipulation, management, and access services. It unites the variety of collection mechanisms with the variety of tools, thus paving the way for more extensive application of process improvement techniques based on data analysis. 1 Introduction Software process engineering has an adv...
Computer Forensics in Forensis (2008)

Different users apply computer forensic systems, models, and terminology in very different ways. They often make incompatible assumptions and reach different conclusions about the validity and accuracy of the methods they use to log, audit, and present forensic data. This is problematic, because these fields are related, and results from one can be meaningful to the others. We present several forensic systems and discuss situations in which they produce valid and accurate conclusions and also situations in which their accuracy is suspect. We also present forensic models and discuss areas in which they are useful and areas in which they could be augmented. Finally, we present some recommendations about how computer scientists, forensic practitioners, lawyers, and judges could build more complete models of forensics that take into account appropriate legal details and lead to scientifically valid forensic analysis.
Rethinking Influenza (2009)

We have already learned a great deal about fighting influenza, but we need to move from a reactive to a proactive and sustainable stance.
A High Speed CMOS Circuit for 1.244 Gb/s 16×16 ATM Switching (1991)

The paper describes a 0.7?m CMOS switch circuit of 350k-transistors, designed for use in a fully autonomous 16×16 Switching Matrix devoted to telecommunications, capable of switching ATM multiplexes of 1.244 Gb/s. The chip processes 4-bit slices of each incoming multiplex. Seven chips working in parallel are enough to achieve standard ATM cells switching.
Cholangiociliopathies: genetics, molecular mechanisms and potential therapies (2009)

Clarification of molecular mechanisms of hepatic cystogenesis provides an opportunity for the development of targeted therapeutic options in PCLD.
Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (2011)

Tietz textbook of clinical chemistry and molecular diagnostics , Tietz textbook of clinical chemistry and molecular diagnostics , کتابخانه دیجیتال جندی شاپور اهواز
Stress Measurement and Defect Detection in Steel Strands by Guided Stress Waves (2003)

Health monitoring of steel strands is the subject of much research in the nondestructive evaluation and civil engineering communities. This paper deals with a guided stress wave method for stress monitoring and defect detection in seven-wire strands. A simplified acoustoelastic formulation of the Pochhammer-Chree vibrations in cylindrical waveguides is derived in the framework of the partial wave representation for guided waves. Magnetostrictive transducers are used to excite and detect the waves in the experiments. Results from acoustoelastic measurements on single wires and on strands are presented, showing the feasibility of the method for stress measurement, although an anomalous behavior of the strands at low stress levels remains the subject of current investigation. Improvements to the inherently low sensitivity of acoustoelastic stress measurements are suggested by adding the effect of strand elongation. The role of the strand anchorages is also examined in the context of wave attenuation. Finally, the suitability of the guided wave method for the detection of indentations and broken wires in the strands is demonstrated, including the possibility of inspecting the critical anchored regions.
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring (2016)

Eosinophilic esophagitis (EoE) is diagnosed by symptoms, and at least 15 intraepithelial eosinophils per high power field in an esophageal biopsy. Other pathologic features have not been emphasized. We developed a histology scoring system for esophageal biopsies that evaluates eight features: eosinophil density, basal zone hyperplasia, eosinophil abscesses, eosinophil surface layering, dilated intercellular spaces (DIS), surface epithelial alteration, dyskeratotic epithelial cells, and lamina propria fibrosis. Severity (grade) and extent (stage) of abnormalities were scored using a 4-point scale (0 normal; 3 maximum change). Reliability was demonstrated by strong to moderate agreement among three pathologists who scored biopsies independently (P ≤ 0.008). Several features were often abnormal in 201 biopsies (101 distal, 100 proximal) from 104 subjects (34 untreated, 167 treated). Median grade and stage scores were significantly higher in untreated compared with treated subjects (P ≤ 0.0062). Grade scores for features independent of eosinophil counts were significantly higher in biopsies from untreated compared with treated subjects (basal zone hyperplasia P ≤ 0.024 and DIS P ≤ 0.005), and were strongly correlated (R-square >0.67). Principal components analysis identified three principal components that explained 78.2% of the variation in the features. In logistic regression models, two principal components more closely associated with treatment status than log distal peak eosinophil count (PEC) (R-square 17, area under the curve (AUC) 77.8 vs. R-square 9, AUC 69.8). In summary, the EoE histology scoring system provides a method to objectively assess histologic changes in the esophagus beyond eosinophil number. Importantly, it discriminates treated from untreated patients, uses features commonly found in such biopsies, and is utilizable by pathologists after minimal training. These data provide rationales and a method to evaluate esophageal biopsies for features in addition to PEC.
Establishment of a particle-counting method for purified elementary bodies of chlamydiae and evaluation of sensitivities of the IDEIA Chlamydia kit and DNA probe by using the purified elementary bodies (1992)

To evaluate the sensitivity of commercially available test kits for detection of chlamydiae, we established a method of purifying Chlamydia trachomatis and Chlamydia pneumoniae elementary bodies (EBs). We then subjected the purified EBs, together with the purified EBs of Chlamydia psittaci, to the IDEIA Chlamydia (IDEIA) and DNA probe test kits to determine the EB numbers at the detection limits. The sensitivities of the test kits were thus compared. The results can be summarized as follows. (i) Intact EBs in the purified preparations were present at 100, 96.3, and 97% for the C. psittaci Cal 10, C. trachomatis L2/434/Bu (L2), and C. pneumoniae TW-183 strains, respectively. The preparations of the L2 and TW-183 EBs contained a few EB envelopes, which reacted with antilipopolysaccharide monoclonal antibodies, as did the intact EBs, indicating that elimination of EB envelopes is not required for testing of the IDEIA kit's sensitivity. (ii) We established a method of counting intact EBs and EB envelopes under a scanning electron microscope after sedimentation of EBs on a coverslip by centrifugation. (iii) The EB numbers per assay at the cutoff level, which is set up in the IDEIA kit, were 9.6 x 10(2), 6.5 x 10(3), and 2.5 x 10(4) for the L2, TW-183, and Cal 10 strains, respectively. When the same EB preparations were applied to the DNA probe kit, the EB number at the cutoff level was 7.5 x 10(3) per assay for the L2 strain, but no reaction occurred for the Cal 10 and TW-183 strains at any EB number, indicating that the DNA probe kit is highly specific for C. trachomatis. Although the IDEIA kit designed for detection of C. trachomatis showed a sensitivity superior to that of the DNA probe, the chlamydial species was not determined by the IDEIA kit.