gebhart/patrepeval huggingface dataset:
<i>p</i>-Diazobenzoyl-biocytin: a new biotinylating reagent for DNA (1988)

Journal Article p -Diazobenzoyl-biocytin: a new biotinylating reagent for DNA Get access Jeffrey M. Rothenberg, Jeffrey M. Rothenberg Department of Biophysics, The Weizmann Institute of ScienceRehovot 76100, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar Meir Wilchek Meir Wilchek Department of Biophysics, The Weizmann Institute of ScienceRehovot 76100, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 14, 25 July 1988, Page 7197, https://doi.org/10.1093/nar/16.14.7197 Published: 25 July 1988 Article history Received: 16 May 1988 Published: 25 July 1988
Studies on polyyne polymers containing transition metals in the main chain. IV. Polymer synthesis by oxidative coupling of transition metal‐bis(acetylide) complexes (1980)

Abstract The metal‐polyyne polymers consisting of transition metals and conjugated tetrayne systems magnified image where M represents Pt(PBu 3 ) 2  or Pd(PBu 3 ) 2  moiety were prepared by the oxidative coupling method and characterized by spectral analysis, associated with novel depolymerization giving binuclear transition metal complexes, and
Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin (2005)

Flagellin is the major protein component of the flagella from motile bacteria and was identified as the ligand for toll-like receptor (TLR)-5. Whereas its effects on epithelial cells have been studied in detail, activation of human peripheral blood mononuclear cells (PBMC) by flagellin is characterized only partially. By using the recombinant protein of Salmonella muenchen we confirm the proinflammatory nature of flagellin as detected by nuclear factor-kappaB activation and interleukin (IL)-8 production. Aim of the current study was to elucidate in PBMC effects of flagellin on IL-18 and Th1-like cytokine responses. We report that flagellin in pathophysiologically relevant concentrations augmented release of mature IL-18 by THP-1 monocytes, PBMC, and whole blood stimulated with nigericin or by ATP-mediated P2X7 purinergic receptor activation. Further key functions of the IL-18/IL-12/interferon-gamma (IFNgamma) pathway were upregulated by flagellin. Flagellin synergized with IL-12 for production of IFN-gamma and augmented secretion of interferon-inducible protein-10, a CXC-chemokine that is key to the generation of Th1-type responses. In contrast, neither IL-18-binding protein nor IL-4 was affected. Taken together, the present data demonstrate for the first time that flagellin at concentrations that are detectable in the blood compartment during sepsis efficiently enhances the IL-18/IL-12/IFNgamma pathway and thus Th1-like cytokine responses in PBMC.
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes (2021)

Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human monocytes, experimentally infected, and from patients under intensive care. Pyroptosis associated with caspase-1 activation, IL-1ß production, gasdermin D cleavage, and enhanced pro-inflammatory cytokine levels in human primary monocytes. At least in part, our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe COVID-19.
Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics (2015)

Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology characterized by hypergammaglobulinemia, autoantibodies detection and interface hepatitis. Due to the absence of specific diagnostic markers and the large heterogeneity of its clinical, laboratory and histological features, AIH diagnosis may be potentially difficult. Therefore, in this in-depth review we summarize the substantial progress on etiopathogenesis, clinical, serological and histological phenotypes of AIH. AIH has a global distribution affecting any age, both sexes and all ethnic groups. Clinical manifestations vary from asymptomatic to severe or rarely fulminant hepatitis. Hypergammaglobulinemia with selective elevation of IgG is found in most cases. Autoimmune attack is perpetuated, possibly via molecular mimicry, and favored by the impaired control of T-regulatory cells. Histology (interface hepatitis, emperipolesis and hepatic rosette formation) and autoantibodies detection although not pathognomonic, are still the hallmark for a timely diagnosis. AIH remains a major diagnostic challenge. AIH should be considered in every case in the absence of viral, metabolic, genetic and toxic etiology of chronic or acute hepatitis. Laboratory personnel, hepato-pathologists and clinicians need to become more familiar with disease expressions and the interpretation of liver histology and autoimmune serology to derive maximum benefit for the patient.
Zoysiagrass Species and Genotypes Differ in Their Winter Injury and Freeze Tolerance (2007)

Lack of cold hardiness may limit widespread use of newly released zoysiagrass ( Zoysia spp.) cultivars in the transition zone. Our objectives were to quantify differences in the winter injury of 35 zoysiagrass genotypes in field plots in West Lafayette, IN, and the freeze tolerance of 13 genotypes in a cold stress simulator as well as determine the relationship between leaf width, establishment rate, and autumn growth with winter injury. Winter injury varied between years and among genotypes in the field study. Zoysia japonica Steud. genotypes had less winter injury each year than Z. matrella (L.) Merr. genotypes. Genotypes of Z. japonica available as seed had less winter injury (2% in both years) than genotypes of Z. japonica (41%, 2005; 54%, 2006) and Z. matrella (51%, 2005; 73%, 2006) available only as vegetative propagules. ‘Meyer’, ‘Chinese Common’, and ‘Zenith’ were the commercially available cultivars exhibiting the least winter injury (<7%) in both years, whereas ‘Victoria’, ‘DeAnza’, ‘Diamond’, and ‘Empress’ had the most winter injury (>88%) both years. There was a relationship ( r 2 = 0.48, P = 0.0088) between freeze tolerance (LT 50 ) in the cold stress simulator and winter injury in the field. Freeze tolerance ranged from −8.4°C (Diamond) to −11.5°C (Meyer and Zenith). Meyer has been the industry standard for zoysiagrass, but our research has identified other commercially available cultivars and genotypes with winter injury similar to Meyer.
Biological Surface Features of Semiarid Lands (1991)

The lack of water in semiarid and desert regions restricts the development of vascular plant cover. As a result, most of the surface of the ground is exposed to full sunlight and the elements, in response to which a heterogeneous mix of microbiological and cryptogamic communities often occurs. Biological surface communities in semiarid lands and hot and cold deserts show a superficial similarity around the globe. Among factors most influential in determining the kinds of biological surface features and their activities are parent materials (mineral substrates), soil texture, light, source and availability of water, temperature regime, topography, history of use, and time.
Virtual Inline: A Technique of Combining IDS and IPS Together in Response Intrusion (2009)

The Intrusion Detection Systems (IDSs) play an important role in monitoring networks, but they lack abilities in automated intrusion response; the Intrusion Prevention Systems (IPSs) can guard networks in entrance, but they have no abilities in response inner-intranet attacks; many proposals focus on solutions in automated intrusion response, but they still have various problems existed, the main challenge is the accurate measurement of those related factors. This paper presents a virtual inline technique which is based on the technique of the Man in the Middle attack (MITM), it combines the NIDS and NIPS together in providing all-wave protection to networks. This technique integrates the advantages of both IDSs and IPSs, and avoids their shortages; it also avoids those problems baffle our researchers in this field. Empirical experiments show this technique is practicable.
Role of cGAS–Sting Signaling in Alzheimer’s Disease (2023)

There is mounting evidence that the development of Alzheimer's disease (AD) interacts extensively with immunological processes in the brain and extends beyond the neuronal compartment. Accumulation of misfolded proteins can activate an innate immune response that releases inflammatory mediators and increases the severity and course of the disease. It is widely known that type-I interferon-driven neuroinflammation in the central nervous system (CNS) accelerates the development of numerous acute and chronic CNS diseases. It is becoming better understood how the cyclic GMP-AMP synthase (cGAS) and its adaptor protein Stimulator of Interferon Genes (STING) triggers type-I IFN-mediated neuroinflammation. We discuss the principal elements of the cGAS-STING signaling pathway and the mechanisms underlying the association between cGAS-STING activity and various AD pathologies. The current understanding of beneficial and harmful cGAS-STING activity in AD and the current treatment pathways being explored will be discussed in this review. The cGAS-STING regulation offers a novel therapeutic opportunity to modulate inflammation in the CNS because it is an upstream regulator of type-I IFNs.
The Legal Perspective (1988)

The Korean War stimulated discussion in and out of government about the laws of war, and quite often the question of neutrality was also addressed.1 It was not a great debate; on the contrary, relatively few people were involved in only a limited number of publications.2 But the effort had a clear impact leading to new official formulations of the laws of war and of neutrality. By 1957, both the United States Army and the United States Navy had reworked and restated their positions on the subject.
Rotating penning surface-plasma source for dc H/sup -/ beams (1980)

The possibility of using a Penning surface-plasma source (SPS) with rotating electrodes to produce dc H/sup -/ beams is investigated. In this rotating ion source (RIS), the average power density on the electrodes is reduced by magnetically confining the discharge to a small region near the emission slit while maintaining the geometry and instantaneous power density of the fixed-electrode Penning SPS. H/sup -/ beam currents (2.5 mA at 100% duty factor, 104 mA at 1.5% duty factor) and two-dimensional normalized emittances (0.036 ..pi.. cm.mrad x 0.009 ..pi.. cm.mrad for 40% of a 1.5-mA, dc H/sup -/ beam) similar to those of the fixed-electrode Penning SPS are produced by the uncooled RIS reported in this paper. The scaling to a 100% duty factor, fully cooled RIS is briefly discussed.
Interictal Sharp EEG Transients in Neonatal Seizures (1989)

This study describes the differences between several quantifiable variables that characterize interictal sharp EEG transients (SETS) recorded from neurologically ill neonates with proven electrographic seizures and a comparison group of apparently neurologically well babies with no known seizures. The abundance (number of sharp EEG transients per ten minutes), waveform morphology, repetitive behavior, and spatial distribution of SETS provide interpretive guidelines that help discriminate between these two patient populations.
Prevention of surface mold growth on Italian dry sausage by natamycin and potassium sorbate (1981)

Inhibition of uncontrolled mold growth on three types of raw cured Italian dry salami was studied under commercial production conditions. Salami were dipped or sprayed with natamycin (pimaricin) or were given a combined organic acid-plus-potassium sorbate treatment. Acetic and citric acids potentiated the inhibitory effects of potassium sorbate significantly, but lactic and succinic acids showed little or no effect. Treatment of salami by dipping in 2.5% (wt/vol) potassium sorbate or 2,000 ppm (mg/liter) of pimaricin did not successfully prevent the growth of surface molds. At 10% potassium sorbate on all types of salami and at 2.5% sorbate on Casalingo salami, visual inhibition of mold growth was observed, but numbers of viable fungi on all salami types treated with 2.5% sorbate were not significantly (95% confidence) different from numbers found in the untreated controls. Pimaricin spray (2 X 1,000 ppm) was as good as or slightly better than 2.5% potassium sorbate, but greater concentrations of each were required to satisfactorily inhibit surface mold growth during the 25- to 50-day ripening period.
Urodynamics in Elderly Women with Stress Urinary Incontinence (1987)

No AccessJournal of Urology1 Jun 1987Urodynamics in Elderly Women with Stress Urinary Incontinence Pranikoff Kevin, Patricia A. Burns, and Janet S. Reis Pranikoff KevinPranikoff Kevin More articles by this author , Patricia A. BurnsPatricia A. Burns More articles by this author , and Janet S. ReisJanet S. Reis More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)75462-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Urodynamics in Elderly Women with Stress Urinary Incontinence." The Journal of Urology, 137(6), p. 181A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 181A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Pranikoff Kevin More articles by this author Patricia A. Burns More articles by this author Janet S. Reis More articles by this author Expand All Advertisement PDF DownloadLoading ...
Advantages of Fuels with High Resistance to Auto-ignition in Late-injection, Low-temperature, Compression Ignition Combustion (2006)

<div class="htmlview paragraph">Oxides of nitrogen (NOx) and smoke can be simultaneously reduced in compression ignition engines by getting combustion to occur at low temperatures and by delaying the heat release till after the fuel and air have been sufficiently mixed. One of the ways to obtain such combustion in modern engines using common-rail direct injection is to inject the fuel near top dead centre with high levels of exhaust gas recirculation (EGR) - Nissan MK style combustion. In this work we study the effect of fuel auto-ignition quality, using four fuels ranging from diesel to gasoline, on such combustion at two inlet pressures and different EGR levels. The experiments are done in a 2 litre single-cylinder engine with a compression ratio of 14 at an engine speed of 1200 RPM. The engine can be easily run on gasoline with a single injection near TDC, even though it cannot be run with very early injection, in the HCCI mode. Moreover for any given condition, gasoline has a significantly higher ignition delay for the same combustion phasing and hence results in very much lower NOx and smoke for a given load compared to diesel fuels. Using gasoline, an IMEP of 14.86 bar could be reached with ISFC of 178 g/kWh, smoke &lt; 0.4 FSN, peak pressure of 133 bar, ISNOx of 1.21 g/kWh, and ISHC and ISCO &lt; 4 g/kWh. It was not possible to get comparable performance with diesel fuels with low smoke at the same operating conditions. Further improvements in all these parameters using gasoline should be possible by optimising injector and engine design and operating conditions and bringing in other strategies such as multiple injections.</div>
Pregnancy rates following the exclusive transfer of twice frozen twice thawed embryos using a modified slow cool cryopreservation technique. (2013)

These data suggest that twice frozen twice thawed embryos should not be discarded but either transferred alone if they are the only embryos left, or mixed with frozen embryos that have never been thawed. Though the live delivered pregnancy rates are inferior to fresh embryo transfer the marked reduction in cost and avoidance of the risk of ovarian hyperstimulation justifies their transfer.
X-Tile (2004)

The ability to parse tumors into subsets based on biomarker expression has many clinical applications; however, there is no global way to visualize the best cut-points for creating such divisions. We have developed a graphical method, the X-tile plot that illustrates the presence of substantial tumor subpopulations and shows the robustness of the relationship between a biomarker and outcome by construction of a two dimensional projection of every possible subpopulation. We validate X-tile plots by examining the expression of several established prognostic markers (human epidermal growth factor receptor-2, estrogen receptor, p53 expression, patient age, tumor size, and node number) in cohorts of breast cancer patients and show how X-tile plots of each marker predict population subsets rooted in the known biology of their expression.
Induction/Engineering, Detection, Selection, and Expansion of Clinical-Grade Human Antigen-Specific<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mtext>CD</mml:mtext><mml:msup><mml:mtext>8</mml:mtext><mml:mtext>+</mml:mtext></mml:msup></mml:math>Cytotoxic T Cell Clones for Adoptive Immunotherapy (2010)

Adoptive transfer of effector antigen-specific immune cells is becoming a promising treatment option in allogeneic transplantation, infectious diseases, cancer, and autoimmune disorders. Within this context, the important role of CD8+ cytotoxic T cells (CTLs) is objective of intensive studies directed to their in vivo and ex vivo induction, detection, selection, expansion, and therapeutic effectiveness. Additional questions that are being addressed by the scientific community are related to the establishment and maintenance of their longevity and memory state as well as to defining critical conditions underlying their transitions between discrete, but functionally different subtypes. In this article we review and comment latest approaches and techniques used for preparing large amounts of antigen-specific CTLs, suitable for clinical use.
Analysis and Realization of TLC or even QLC Operation with a High Performance Multi-times Verify Scheme in 3D NAND Flash memory (2018)

Feasibility of multi-times verify (MTV) scheme on triple-level cell (TLC) and quad-level cell (QLC) operations of charge-trap storage 3D NAND memories is investigated comprehensively. Results reveal that random telegraph noise (RTN) and program noise are the major factors affecting lower (LB) and upper boundaries (HB) of Vt distribution, respectively. Enlargement of operation window and reduction of ECC usage with MTV scheme to mitigate RTN-induced LB tail are demonstrated on TLC and QLC operations. In addition, the impact of program noise on HB Vt under various process conditions and ISPP steps is studied experimentally and also explained by our Monte Carlo simulator. Finally, program performance and reserved margin with and without MTV scheme applied on TLC and QLC operation are demonstrated.
Low-Cost, Dendrite-Blocking Polymer-Sb<sub>2</sub>O<sub>3</sub>Separators for Lithium and Sodium Batteries (2014)

We describe here preparation and performance of an ultra-flexible and low-cost Sb2O3/polymer composite membrane separator for Na-ion or Li-ion batteries operating with metallic Na or Li anodes. The separator has a large electrolyte window, excellent thermal and mechanical stabilities when infused with EC/DEC/AClO4 (1M) electrolyte (A = Li or Na), excellent wettability and acceptable ionic conductivity to 1C rate. The ability of the separator to block anode dendrites from crossing it is demonstrated in symmetric alkali-metal cells and in the performances of Na-ion and Li-ion cells with/without loading with Sb2O3.
A Comparison of the Diagnostic Accuracy of<sup>18</sup>F-FDG PET and CT in the Characterization of Solitary Pulmonary Nodules (2008)

Definitely and probably benign results on PET and CT strongly predict benign SPN. However, such results were 3 times more common with PET. Definitely malignant results on PET were much more predictive of malignancy than were these results on CT. A malignant final diagnosis was approximately 10 times more likely than a benign final diagnosis in participants with PET results rated definitely malignant.
Overview of tag switching (2002)

Networks are evolving to combine network layer routing and link layer switching to provide advanced services at high speeds. Tag switching is a new technology for tightly integrating routing and switching in a flexible manner. This paper presents an overview of tag switching technology and how it can be employed in enterprise and service provider networks.
Directed Colloidal Assembly of Linear and Annular Lead Zirconate Titanate Arrays (2004)

Lead zirconate titanate (PZT) arrays for ultrasonic sensing applications in the 2–30‐MHz frequency range were fabricated by robocasting, a directed colloidal assembly technique. Both linear and annular arrays were produced by robotically depositing a concentrated PZT gel‐based ink to create high‐aspect‐ratio PZT elements (thickness ∼ 130 μm and height ∼1–2 mm) of varying pitch (∼250–410 μm). The arrays were densified and infiltrated with an epoxy resin to fabricate PZT–polymer composites with 2–2 connectivity. Their dielectric and piezoelectric constants were measured and compared with values obtained for bulk PZT and those predicted theoretically.
Noise properties of the EM algorithm. II. Monte Carlo simulations (1994)

In an earlier paper we derived a theoretical formulation for estimating the statistical properties of images reconstructed using the iterative ML-EM algorithm. To gain insight into this complex problem, two levels of approximation were considered in the theory. These techniques revealed the dependence of the variance and covariance of the reconstructed image noise on the source distribution, imaging system transfer function, and iteration number. In this paper a Monte Carlo approach was taken to study the noise properties of the ML-EM algorithm and to test the predictions of the theory. The study also served to evaluate the approximations used in the theory. Simulated data from phantoms were used in the Monte Carlo experiments. The ML-EM statistical properties were calculated from sample averages of a large number of images with different noise realizations. The agreement between the more exact form of the theoretical formulation and the Monte Carlo formulation was better than 10% in most cases examined, and for many situations the agreement was within the expected error of the Monte Carlo experiments. Results from the studies provide valuable information about the noise characteristics of ML-EM reconstructed images. Furthermore, the studies demonstrate the power of the theoretical and Monte Carlo approaches for investigating noise properties of statistical reconstruction algorithms.