gebhart/patrepeval huggingface dataset:
A deflectable guiding catheter for real‐time MRI‐guided interventions (2011)

Kevlar and short nitinol component substitutions preserved mechanical properties. The active design offered the best visibility and usability but reintroduced metal conductors. We describe versatile deflectable guiding catheters with a 0.057" lumen for interventional MRI catheterization. Implementations are feasible using active, inductive, and passive visualization strategies to suit application requirements.
Evaluation of a MAb-PAM4-defined MUC1 immunoassay as a potentially new diagnostic test for pancreatic cancer (2005)

4102 Background: At the present time there are no reliable methods for the early detection and diagnosis of pancreatic cancer. Since the PAM4 MAb identifies an epitope that is more restricted to pancreatic cancer than other MUC1-producing forms of cancer, we developed an immunoassay to quantitate this antigen in serum specimens. Methods: The immunoassay consists of MAb-PAM4 as the capture reagent and an IgG fraction derived from a polyclonal, anti-MUC1 antiserum as the probe. The former reagent provides specificity and the latter a high signal output. Results: At a cutoff value of 10.2 units/ml, 41 of 53 (77%) pancreatic cancer patients were positive, with a median value of 31.7 units/ml, while none of the 20 normal specimens and only 2 of 32 (6%) pancreatitis sera were positive. ROC analyses for discrimination of pancreatic cancer from normal and pancreatitis specimens provided an area under the curve (AUC) of 0.88 (95% CI, 0.81 - 0.95), with a specificity of 96% and a positive likelihood ratio of 20.5. Of the 53 pancreatic cancer specimens, 41 were assessable for both PAM4-MUC1 and CA19–9. Of these, 24 (59%) were considered positive for CA19–9 (at a cutoff of 35 units/ml). As with the PAM4-MUC1 assay, none of the normal specimens was positive. However, of the 32 pancreatitis samples, CA19–9 was positive in 38%. ROC analyses for discrimination of pancreatic cancer from normal and pancreatitis serum specimens provided an AUC of 0.74 (95% CI, 0.63 - 0.84), with a specificity of 77% and a positive likelihood ratio of 2.59. Statistical analyses for PAM4-MUC1 in this same subset of pancreatic cancer sera differed little from the group analyses discussed above; sensitivity for this subset was slightly reduced (71%), but specificity remained high (96%), as did the positive likelihood ratio (18.7). Conclusions: These initial data suggest that the PAM4-MUC1 assay may offer a significant improvement over the CA19–9 assay for the discrimination of pancreatic cancer from normal and pancreatitis populations. (Supported in part by grants CA92723 and CA98488 from the NIH.) Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Immunomedics Immunomedics
Development of a Continuous Lactulose Process: Separation and Purification (1995)

Abstract We developed a continuous pilot plant process to produce lactulose from lactose using boric acid to boost the conversion to about 75%. The process consists of three reactors (two continuous stirred tank reactors followed by a tubular reactor), pH adjustment, a crystallizer—filter—evaporator recycle initial separation section, and a chromatographic purification system to produce lactulose containing less than 1–5 ppm of boric acid. The continuous process operates at 0.53 kg/min (20% solids) through the reactors and about 0.3 kg/min (55% solids) out of the initial separation section. The chromatographic separation is at the prep scale with a flow rate of 2.0 mL/min. The final product is a 55% solids syrup containing no detectable boric acid.
Automated Segmentation of Breast in 3-D MR Images Using a Robust Atlas (2014)

This paper presents a robust atlas-based segmentation (ABS) algorithm for segmentation of the breast boundary in 3-D MR images. The proposed algorithm combines the well-known methodologies of ABS namely probabilistic atlas and atlas selection approaches into a single framework where two configurations are realized. The algorithm uses phase congruency maps to create an atlas which is robust to intensity variations. This allows an atlas derived from images acquired with one MR imaging sequence to be used to segment images acquired with a different MR imaging sequence and eliminates the need for intensity-based registration. Images acquired using a Dixon sequence were used to create an atlas which was used to segment both Dixon images (intra-sequence) and T1-weighted images (inter-sequence). In both cases, highly accurate results were achieved with the median Dice similarity coefficient values of 94% ±4% and 87 ±6.5%, respectively.
“Spiral COSAMI” — A Multi-Undulator Compact Source for Actinic Mask Inspection in the extreme ultraviolet range (2021)

A compact electron storage ring provides a bright, stable and reliable source of extreme ultraviolet (EUV) radiation for metrology applications in semiconductor industry. The COSAMI concept (COmpact Synchrotron for Actinic Mass Inspection) applied design principles and technology of modern diffraction limited light source storage rings to an EUV facility operating at 13.5 nm wavelength. Since floor space is an important issue in an industrial environment, we propose a lattice configuration where three (or more) recirculation turns are stacked vertically. We present a facility, called Spiral-COSAMI, which simultaneously serves multiple (three or more) EUV beamlines within about the same floor space of the original COSAMI, and using the same type of injector and the same set of diagnostics, radio-frequency and pulsed magnet devices. The increased period of revolution of the multiple turns mitigates the problem of ion trapping and relaxes specifications of injection kickers.
Photo Aesthetics Ranking Network with Attributes and Content Adaptation (2016)

Real-world applications could benefit from the ability to automatically generate a fine-grained ranking of photo aesthetics. However, previous methods for image aesthetics analysis have primarily focused on the coarse, binary categorization of images into high- or low-aesthetic categories. In this work, we propose to learn a deep convolutional neural network to rank photo aesthetics in which the relative ranking of photo aesthetics are directly modeled in the loss function. Our model incorporates joint learning of meaningful photographic attributes and image content information which can help regularize the complicated photo aesthetics rating problem. To train and analyze this model, we have assembled a new aesthetics and attributes database (AADB) which contains aesthetic scores and meaningful attributes assigned to each image by multiple human raters. Anonymized rater identities are recorded across images allowing us to exploit intra-rater consistency using a novel sampling strategy when computing the ranking loss of training image pairs. We show the proposed sampling strategy is very effective and robust in face of subjective judgement of image aesthetics by individuals with different aesthetic tastes. Experiments demonstrate that our unified model can generate aesthetic rankings that are more consistent with human ratings. To further validate our model, we show that by simply thresholding the estimated aesthetic scores, we are able to achieve state-or-the-art classification performance on the existing AVA dataset benchmark.
Distributed Cross-Domain Change Management (2009)

Distributed systems increasingly span organizational boundaries and, with this, system and service management domains. Web services are the primary means of exposing services to clients, be it in electronic commerce, Software-as-a-Service (SaaS) or on cloud platforms and are being used and integrated with customer-managed applications as well as in complex mashups. Maturing cross-domain relationships and an increase in loose coupling and ad-hocness makes managing configuration changes, e.g., changes in interfaces or endpoints, increasingly relevant. Traditional service management processes within organizations, in particular change management, relies on a central configuration management database (CMDB) to assess the impact a change has on other components of the system. However, this approach does not work in a cross-domain environment, due to the lack of a central CMDB, centralized management processes, and knowledge by service providers which clients depends on their respective services. This paper proposes the Change 2.0 approach to cross-domain change management based on an inversion of responsibility for impact assessment and the facilitation of cross-domain service process integration. We present the requirements imposed by cross-domain change management, the Change 2.0 architecture, and a brief evaluation of its benefits.
Extension to the Session Description Protocol (SDP) for Bypass of Border Gateways (2008)

This document describes an extension to the Session Description
Protocol (SDP) that can be used by systems of cooperating networks
using Application Level Gateways (ALG) to insert border gateways
performing as Network Address Port Translators (NAPT) between their IP
realms to identify when border gateways can be bypassed for more
efficient media flow. This extension can be used by networks based on
a protocol using the SDP offer/answer model, such as the IP Multimedia
Subsystem (IMS) of the Third Generation Partnership Project (3GPP),
which is based on the Session Initiation Protocol (SIP). ALGs using
this extension can determine within a single SDP offer/answer
transaction when the insertion of a new border gateway would cause the
media path to re-enter an IP realm visited elsewhere within the media
path, and to bypass one or more border gateways that would otherwise
be included in the media path. This extension also works with hosted
NAPT traversal schemes to establish a direct media path between
endpoints within the same IP realm. Optional procedures provide
additional means to improve media flow.
ERG REGULATES C-MYC AND ABROGATES DIFFERENTIATION IN PROSTATE CANCER (2009)

You have accessJournal of Urology1 Apr 2009ERG REGULATES C-MYC AND ABROGATES DIFFERENTIATION IN PROSTATE CANCER Albert Dobi, Chen Sun, Ahmed Mohamed, Hongyun Li, Rajesh Thangapazham, Bungo Furusato, Syed Shaheduzzaman, Shyh-Han Tan, Eric Whitman, Dorota Hawksworth, Yongmei Chen, Mariann Vahey, Vyomesh Patel, J. Silvio Gutkind, Taduru Sreenath, Gyorgy Petrovics, Isabell A Sesterhenn, David G McLeod, and Shiv Srivastava Albert DobiAlbert Dobi More articles by this author , Chen SunChen Sun More articles by this author , Ahmed MohamedAhmed Mohamed More articles by this author , Hongyun LiHongyun Li More articles by this author , Rajesh ThangapazhamRajesh Thangapazham More articles by this author , Bungo FurusatoBungo Furusato More articles by this author , Syed ShaheduzzamanSyed Shaheduzzaman More articles by this author , Shyh-Han TanShyh-Han Tan More articles by this author , Eric WhitmanEric Whitman More articles by this author , Dorota HawksworthDorota Hawksworth More articles by this author , Yongmei ChenYongmei Chen More articles by this author , Mariann VaheyMariann Vahey More articles by this author , Vyomesh PatelVyomesh Patel More articles by this author , J. Silvio GutkindJ. Silvio Gutkind More articles by this author , Taduru SreenathTaduru Sreenath More articles by this author , Gyorgy PetrovicsGyorgy Petrovics More articles by this author , Isabell A SesterhennIsabell A Sesterhenn More articles by this author , David G McLeodDavid G McLeod More articles by this author , and Shiv SrivastavaShiv Srivastava More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)61441-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ERG REGULATES C-MYC AND ABROGATES DIFFERENTIATION IN PROSTATE CANCER." The Journal of Urology, 181(4S), pp. 510–511 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 510-511 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Albert Dobi More articles by this author Chen Sun More articles by this author Ahmed Mohamed More articles by this author Hongyun Li More articles by this author Rajesh Thangapazham More articles by this author Bungo Furusato More articles by this author Syed Shaheduzzaman More articles by this author Shyh-Han Tan More articles by this author Eric Whitman More articles by this author Dorota Hawksworth More articles by this author Yongmei Chen More articles by this author Mariann Vahey More articles by this author Vyomesh Patel More articles by this author J. Silvio Gutkind More articles by this author Taduru Sreenath More articles by this author Gyorgy Petrovics More articles by this author Isabell A Sesterhenn More articles by this author David G McLeod More articles by this author Shiv Srivastava More articles by this author Expand All Advertisement PDF downloadLoading ...
A Quality-of-Experience Index for Streaming Video (2016)

With the rapid growth of streaming media applications, there has been a strong demand of quality-of-experience (QoE) measurement and QoE-driven video delivery technologies. Most existing methods rely on bitrate and global statistics of stalling events for QoE prediction. This is problematic for two reasons. First, using the same bitrate to encode different video content results in drastically different presentation quality. Second, the interactions between video presentation quality and playback stalling experiences are not accounted for. In this work, we first build a streaming video database and carry out a subjective user study to investigate the human responses to the combined effect of video compression, initial buffering, and stalling. We then propose a novel QoE prediction approach named Streaming QoE Index that accounts for the instantaneous quality degradation due to perceptual video presentation impairment, the playback stalling events, and the instantaneous interactions between them. Experimental results show that the proposed model is in close agreement with subjective opinions and significantly outperforms existing QoE models. The proposed model provides a highly effective and efficient meanings for QoE prediction in video streaming services. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup>
Colorimetry of angiotensin-I converting enzyme activity in serum. (1981)

This simple, accurate, and reproducible colorimetric method for determining the activity of angiotensin-I converting enzyme is based upon colorimetry of the quinoneimine dye produced from the substrate p-hydroxyhippuryl-L-histidyl-L-leucine by action of this enzyme through the following series of reactions. The enzyme acts on the substrate to yield p-hydroxyhippuric acid and L-histidyl-L-leucine. The former is then hydrolyzed in the presence of hippuricase to produce p-hydroxybenzoic acid and glycine. Finally, oxidative coupling of p-hydroxybenzoic acid with 4-aminoantipyrine is catalyzed by peroxidase in the presence of hydrogen peroxide, producing a quinoneimine dye, the concentration of which is measured at its absorbance maximum at 505 nm to evaluate the activity of ACE. The Km value for the above-mentioned substrate is 0.32 mmol/L, the optimum pH is 8.3. Results by the present method and Cushman and Cheung's method (Biochem. Pharmacol. 20: 1637, 1971) correlate closely (r = 0.986). The within-run CV is 2.93%.
High-Efficiency Microarray Printer Using Fused-Silica Capillary Tube Printing Pins (2008)

We describe a contact printing approach for microarrays that uses fused-silica capillary tubes with tapered tips for printing pins and a pressure/vacuum system to control pin loading, printing, and cleaning. The printing process is insensitive to variable environmental factors such as humidity, and the small diameter of the pins allows routine printing from 1536 well source plates. Pin load capacity, 0.2 microL in the current system, is adjustable by controlling pin length. More than 2000 spots can be printed per 0.2-microL pin load (<100 pl/spot), and densities of >12,000 spots/cm(2) are readily achievable. Solutions with a wide range of viscosities and chemical properties can be printed. The system can print tens of thousands of different solutions at high speed, due to the ability to use large numbers of pins simultaneously, and can produce a large number of replicate arrays since all of the solution picked up by the pins is available for deposition.
Optical isolators for integrated optics (2008)

Waveguide optical isolators suitable for integrated optics are described, which include a nonreciprocal loss isolator and an interferometric one. A surface activated bonding technique is effective for incorporating a magneto-optic effect in a semiconductor waveguide.
Amplitude-only, passive, broadband, optical spatial cloaking of very large objects (2014)

We demonstrate three amplitude cloaks that can hide very large spatial objects over the entire visible spectrum using only passive, off-the-shelf optics. The cloaked region for all of the devices exceeds 10⁶ mm³, with the largest exceeding 10⁸ mm³. Although unidirectional, these cloaks can hide the cloaked object, even if the object is transversely illuminated or self-illuminated. Due to the small usable solid angle, but simple scaling, these cloaks may be of value in hiding small field-of-view objects such as mid- to high-earth orbit satellites from earth-based observation. Active phase front manipulation can also make these cloaks invisible to some forms of image homodyning.
Etched buried heterostructure GaAs/GaAlAs injection lasers (1975)

An injection laser is described in which a semicircular GaAs active region is completely surrounded by Ga1−xAlxAs by using selective etching and a single liquid-phase epitaxial growth.The active region dimensions can be made much more symmetric than those obtained with conventional stripe geometry lasers resulting in improved optical characteristics and low room-temperature threshold currents.
Synergistic Inhibition of Microbial Sulfide Production by Combinations of the Metabolic Inhibitor Nitrite and Biocides (2006)

MICs of six broad-spectrum biocides and two specific metabolic inhibitors and fractional inhibitory concentration indexes (FICIs) for controlling a sulfide-producing consortium were determined. Nitrite was synergistic (FICI<1) with all but one biocide due to its specific inhibition of dissimilatory sulfite reductase. Hence, combining nitrite with biocides allows more efficient and cost-effective control of sulfate-reducing bacteria.
A Novel Multi-Agent Decision Making Architecture Based on Dual’s Dual Problem Formulation (2016)

In this paper, a novel multi-agent decision making architecture based on dual's dual problem formulation is designed for economic operation. The benefits of such architecture include its limited information exchange among autonomous entities and the ease of implementation. Existing ac optimal power flow (OPF) software packages can be easily incorporated. The proposed decision making is based on dual's dual problem formulation, which is the first time seen in the literature to tackle an OPF problem. Subgradient-based iterative solving procedure results in a multi-agent decision making architecture. Convergence property of the algorithm is analyzed. The application scope of the proposed method is also discussed to identify challenges for meshed networks. Case studies are given to demonstrate the feasibility of the proposed method in providing approximate solutions to IEEE 14-bus system ac OPF. Implementing the proposed decision making architecture in real world is also demonstrated in a dynamic simulation platform.
Complex FIR block adaptive digital filtering algorithm with independent adaptation of real and imaginary filter parameters (2008)

Complex signal representations are being frequently employed in various adaptive filtering applications such as wireless communications, beamforming, etc. In this paper, a novel complex optimum block adaptive algorithm with individual adaptation of parameters (Complex OBAI-LMS) is presented. The proposed technique effectively utilizes the degrees of freedom of the adaptive filter by individually adapting the real and imaginary components of the complex adaptive finite impulse response (FIR) filter coefficients employing optimally derived convergence factors. In addition, the convergence factors are updated at each block iteration. The formulation of the complex OBAI-LMS shows that the update vectors for the real and imaginary components of the adaptive filter coefficients are estimates of the Wiener solution at each iteration. Furthermore, the matrix inversion operation in the formulation is eliminated by processing the input signal in overlapping blocks and applying a matrix inversion lemma. The convergence properties of the complex OBAI-LMS are compared to the block implementation of the complex LMS algorithm in the estimation of a complex FIR filter. Simulation results show that the complex OBAI-LMS yields a significant improvement in convergence speed over the block complex LMS for different input training signals.
Effect of vitamin and trace element supplementation on immune indices in healthy elderly. (1995)

Aging is associated with a progressive decline in the immune system and a greater susceptibility to infection. This double-blind, placebo-controlled study, examined the effect of a vitamin and trace element supplement on immune responses of healthy, noninstitutionalized elderly subjects. Forty-seven subjects aged 61-79 years were randomly assigned to receive placebo or micronutrient supplementation for one year. Thirty-five individuals completed the one-year study. Immune function was assessed before and after the period of supplementation. Cell-mediated immune function assessed by the number of T cells and subsets remained constant in the supplemented group and there was a significant increase in CD57 natural killer cells. In contrast, a significant decrease in T cells, CD4 cells, and CD4: CD8 ratio was noted in the placebo group. Supplementation with micronutrients can play a crucial role in the maintenance of normal immune function in the elderly.
The Practical Synthesis of a Novel and Highly Potent Analogue of Bryostatin (2002)

Macrocycle 1 is a new highly potent analogue of bryostatin 1, a promising anti-cancer agent currently in human clinical trials. In vitro, 1 displays picomolar affinity for PKC and exhibits over 100-fold greater potency than bryostatin 1 when tested against various human cancer cell lines. Macrocycle 1 can be generated in clinically required amounts by chemical synthesis in only 19 steps (LLS) and represents a new clinical lead for the treatment of cancer.
Constructing task visibility intervals for a surveillance system (2005)

One of the goals of a multi-camera surveillance system is to collect useful video clips of objects in the scene. Objects in the collected videos should be unobstructed, in the field of view of the given camera, and meet task-specific resolution requirement. For this purpose, we describe an algorithm that constructs "task visibility intervals", which are tuples of information about what to sense (task-object pairs), when to sense (feasible future temporal intervals to start a task) and how to sense (the camera to use and the corresponding viewing angles and focal length). The algorithm first looks for temporal intervals within which the angular extents of objects overlap each other, causing the object farthest from the given camera to be occluded. Outside these intervals, sub-intervals are then constructed such that feasible camera settings exist for capturing the object. Experimental results are provided to illustrate the system capabilities in constructing such task visibility intervals, followed by scheduling them using a greedy algorithm.