gebhart/patrepeval huggingface dataset:
F-1 (2022)

Description This photograph was taken in 2016 in rural South Texas as a part of a series called <i>Americana</i>, which explores the idea of rural America and its values in spite of a narrative that paints rural regions as bleak and desolate. The owner of this truck pointed it out as an example of reliability, pride, and perseverance-all attributes that were apparent in his community.
DINAMO: interactive protein alignment and model building. (1999)

DINAMO is freely available as a local application or Web-based Java applet at http://tito.ucsc.edu/dinamo
Use of Degradation Tags To Control Protein Levels in the Cyanobacterium Synechocystis sp. Strain PCC 6803 (2013)

We generated a collection of ssrA-based C-terminal protein degradation tags with different degradation strengths. The steady-state fluorescence levels of different enhanced yellow fluorescent protein (eYFP) tag variants in a Synechocystis sp. indicated a tunable range from 1% to 50% of untagged eYFP.
Synthesis of <i>N</i>-acetyl-<scp>l</scp>-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport (1979)

1. The synthesis and efflux of N-acetyl-l-aspartate from brain mitochondria of rats of different ages has been studied. 2. Brain mitochondrial State 3 (+ADP) respiration rate, using 10mm-glutamate and 2.5mm-malate as substrates, increases during the suckling period and reaches approx. 50% of the adult value at 17 days after birth [adult State 3 respiration rate=160+/-7ng-atoms of O/min per mg of mitochondrial protein(mean+/-s.d.; n=3)]. 3. The influence of 5mm-pyruvate or 10mm-dl-3-hydroxybutyrate on aspartate efflux from brain mitochondira from rats of different ages oxidizing glutamate and malate was studied. In all cases the aspartate efflux in State 3 was greater than in State 4, but, whereas the aspartate efflux in State 3 increased as the animals developed, that of State 4 showed only a small increase. However, the rate of aspartate efflux in the presence of pyruvate or 3-hydroxybutyrate as well as glutamate and malate was approx. 60-65% of that in the presence of glutamate and malate alone. 4. An inverse relationship between aspartate efflux and N-acetylaspartate efflux was observed with adult rat brain mitochondria oxidizing 10mm-glutamate and 2.5mm-malate in the presence of various pyruvate concentrations (0-5mm). 5. N-Acetylaspartate efflux by brain mitochondria of rats of different ages was studied in States 3 and 4, utilizing 5mm-pyruvate or 10mm-dl-3-hydroxybutyrate as acetyl-CoA sources. A similar pattern of increase during development was seen in State 3 for N-acetylaspartate efflux as for aspartate efflux (see point 3 above). Also only very small increases in N-acetylaspartate efflux occurred during development in State 4.6. Rat brain mitochondria in the presence of iso-osmotic N-acetylaspartate showed some swelling which was markedly increased in the presence of malate. 7. It is concluded that N-acetylaspartate may be synthesized and exported from both neonatal and adult rat brain mitochondria. It is proposed that the N-acetylaspartate is transported by the dicarboxylic acid translocase and may be an additional mechanism for mitochondrial/cytosolic carbon transport to that of citrate.
DNA Replication from Initiation Zones of Mammalian cells in a Model System (1994)

We reported that DNA replication initiates from the region containing an autonomously replicating sequence from Saccharomyces cerevisiae when negatively supercoiled plasmid DNA is incubated with the proteins required for simian virus 40 DNA replication (Y. Ishimi and K. Matsumoto, Proc. Natl. Acad. Sci. USA 90:5399-5403, 1993). In this study, the DNAs containing initiation zones from mammalian cells were replicated in this model system. When negatively supercoiled DNA containing an initiation zone (2 kb) upstream of the human c-myc gene was incubated with simian virus 40 T antigen as a DNA helicase, HSSB (also called replication protein A), and DNA polymerase alpha-primase complex isolated from HeLa cells, DNA replication was specifically initiated from the center of the initiation zone, which was elongated bidirectionally in the presence of a DNA swivelase. Without HSSB, the level of DNA synthesis was significantly reduced and the localized initiation could not be detected, indicating that HSSB plays an essential role in the initiation of DNA replication. The digestion of negatively supercoiled template DNA with a single-strand-specific nuclease revealed that HSSB stimulated DNA unwinding in the center of the initiation zone where the DNA duplex is relatively unstable. In contrast, DNA replication started from a broad region of an initiation zone downstream of the dihydrofolate reductase gene from chinese hamster ovary cells, but the center of the region was mapped near the origin of bidirectional DNA replication. These results suggested that this system mimics a fundamental process of initiation of eukaryotic DNA replication. The mechanism of initiation is discussed.
A differential 2.4 GHz switched-gain CMOS LNA for 802.11b and Bluetooth (2003)

This report presents a fully differential 2.4 GHz LNA with step gain control for use in IEEE 802.11b and Bluetooth systems. The LNA was fabricated using a commercial 0.25 um 1P5M mixed signal CMOS process. Measured results show a gain of 14.7 dB, noise figure of 2.88 dB and IIP3 of -0.5 dBm. A gain of -14.2 dB and IIP3 of +19 dBm were measured in the switched low gain mode, which will provide an additional 29 dB of dynamic range to a fully integrated receiver.
No-Reference QoE Prediction Model for Video Streaming Service in 3G Networks (2012)

User experience becomes a most crucial factor for the application and promotion of a new technology. Traditional quality of service (QoS) can only measure the objective quality of services and networks, while the quality of experience (QoE), which has become a hot topic in recent years, can reflect subjective feelings more directly from users' perspective. In this paper, we investigate the QoE evaluation method of video streaming service in 3G networks, and propose a no-reference QoE prediction model of video streaming service based on the gradient boosting machine. Our proposed QoE prediction model considered comprehensive parameters from the network layer, the application layer, decoded videos and the user equipment. Simulation results show that the performance of our proposed QoE prediction model outperforms the G.1070 model, in terms of accurate predicted mean opinion score, small root mean squared error, and low time-consuming.
Comparison of acquisition schemes for hyperpolarised <sup>13</sup>C imaging (2015)

The aim of this study was to characterise and compare widely used acquisition strategies for hyperpolarised (13)C imaging. Free induction decay chemical shift imaging (FIDCSI), echo-planar spectroscopic imaging (EPSI), IDEAL spiral chemical shift imaging (ISPCSI) and spiral chemical shift imaging (SPCSI) sequences were designed for two different regimes of spatial resolution. Their characteristics were studied in simulations and in tumour-bearing rats after injection of hyperpolarised [1-(13)C]pyruvate on a clinical 3-T scanner. Two or three different sequences were used on the same rat in random order for direct comparison. The experimentally obtained lactate signal-to-noise ratio (SNR) in the tumour matched the simulations. Differences between the sequences were mainly found in the encoding efficiency, gradient demand and artefact behaviour. Although ISPCSI and SPCSI offer high encoding efficiencies, these non-Cartesian trajectories are more prone than EPSI and FIDCSI to artefacts from various sources. If the encoding efficiency is sufficient for the desired application, EPSI has been proven to be a robust choice. Otherwise, faster spiral acquisition schemes are recommended. The conclusions found in this work can be applied directly to clinical applications.
Acquisition of property on just terms (2023)

An understanding of the Australian Constitution as a framework for government in Australia is critical for any law student interested in ensuring that the rule of law is upheld. Australian Constitutional Law: Concepts and Cases provides an accessible introduction to Australian constitutional law, integrating theory and doctrine. This book provides clear explanations and carefully selected case extracts that are structured conceptually, rather than chronologically, to enable students to understand both the current state of constitutional law doctrine and how to engage in constitutional reasoning. Discussion questions throughout encourage students to consider how the law has evolved and how it can be applied to hypothetical legislation. The second edition has been updated to include commentary on significant recent High Court decisions and a new chapter that examines the scope of the Commonwealth's power to impose taxation. Written by leading constitutional law scholar Luke Beck, Australian Constitutional Law remains an invaluable resource for law students.
The Mneme Persistent Object Store (1989)

THE MNEME PROJECT IS AN INVESTIGATION OF TECHNIQUES FOR INTEGRATING PROGRAMMING LANGUAGE AND DATABASE FEATURES TO PROVIDE BETTER SUPPORT FOR COOPERATIVE, INFORMATION-INTENSIVE TASKS SUCH AS COMPUTER AIDED SOFTWARE ENGINEERING. WE REPORT HERE ON THE MNEME PERSISTENT OBJECT STORE, DISCUSSING THE ORIGINAL DESIGN, THE CONSTRUCTION OF THE INITIAL PROTOTYPE, AND APPROACHES BEING CONSIDERED FOR THE NEXT PROTOTYPE. MNEME STORES `OBJECTS'', WITH A SIMPLE AND GENERAL FORMAT, AND PRESERVES THE IDENTITY OF OF THE OJBECTS AND THEIR STRUCTURAL RELATIONSHIPS. MNEME''S GOALS INCLUDE PORTABILITY, EXTENSIBILITY (ESPECIALLY WITH RESPECT TO OBJECT MANAGEMENT POLICIES), AND LOW OVERHEAD. THE MODEL OF MEMORY THAT MNEME AIMS TO PRESENT IS A SINGLE, COOPERATIVELY SHARED HEAP, DISTRIBUTED ACROSS A COLLECTION OF NETWORKED COMPUTERS.
The first century of cancer chemotherapy. (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.7.2295 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9667241 The first century of cancer chemotherapy. S HellmanxS HellmanSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.7.2295 PDF "The first century of cancer chemotherapy.." Journal of Clinical Oncology, 16(7), pp. 2295–2296© 1998 by American Society of Clinical Oncology
QWIRE Practice: Formal Verification of Quantum Circuits in Coq (2018)

We describe an embedding of the QWIRE quantum circuit language in the Coq proof assistant. This allows programmers to write quantum circuits using high-level abstractions and to prove properties of those circuits using Coq's theorem proving features. The implementation uses higher-order abstract syntax to represent variable binding and provides a type-checking algorithm for linear wire types, ensuring that quantum circuits are well-formed. We formalize a denotational semantics that interprets QWIRE circuits as superoperators on density matrices, and prove the correctness of some simple quantum programs.
‘Makynge Recusancy Deathe Outrighte’? Thomas Pounde, Andrew Willet and The Catholic Question in Early Jacobean England (2004)

With the accession of James VI of Scotland to England’s throne as James I, many English Catholics began hoping that the vexing question of religion would soon be resolved in a manner not unfavourable to their faith. James, after all, was the son of the Catholic Mary Stuart, Queen of Scots, and it seemed not impossible that he would convert to the Catholic faith. The diplomatic contact with Spain that would eventually produce the Treaty of 1604 was already in process and religious toleration was one element in the discussion. But the more significant grounds for Catholics’ hope came most certainly from the position on the English religious question enunciated by the King himself. As his reign began, James seemed to be demonstrating a more favourable attitude towards Catholics than towards Puritans. His Basilikon Down declared the Church of Rome and the Church of England ‘agree in the grounds’, while his first speech to Parliament in March 1604 characterized Catholicism as ‘a religion, falsely called Catholik, but trewly Papist’, while defining the Puritans, as ‘a sect rather than a Religion’.
Isolation and Differential Expression of an Acidic PR-1 cDNA Gene from Soybean Hypocotyls Infected with Phytophthora sojae f. sp. glycines (2000)

Using differential display techniques, a new acidic pathogenesis-related (PR) protein-1 cDNA (GMPRla) gene was isolated from a cDNA library of soybean (Glycinemax L.Merr, cultivar Jangyup) hypocotyls infected by Phytophthora sojae f. sp. glycines. The 741 bp of fulllength GMPRla clone contains an open reading frame of 525 nucleotides encoding 174 amino acid residues (pI 4.23) with a putative signal peptide of 27 amino acids in the N-terminus. Predicted molecular weight of the protein is 18,767 Da. The deduced amino acid sequence of GMPRla has a high level of identity with PR-1 proteins from Brassica napus, Nicotiana tabacum, and Sambucus nigra. The GMPRla mRNA was more strongly expressed in the incompatible than the compatible interaction. The transcript accumulation was induced in the soybbean hypocotyls by treatment with ethephon or DL--amino-n-butyric acid, but not by wounding. In situ hybridization data showed that GMPRIa mRNAs were usually localized in the vascular bundle of hypocotyl tissues, especially phloem tissue. Differences between compatible and incompatible interactions in the timing of GMPRla mRNA accumulation were remarkable, but the spatial distribution of GMPRla mRNA was similar in both interactions. However, more GMPRla mRNA was accumulated in soybean hypocotyls at 6 and 24 h after inoculation.
A Physicists View of Crystal‐Structure Determination (1972)

Abstract The basic operations of crystal‐structure determination are described in terms of optical imaging: the collection of the diffraction data corresponds to the process of scattering by the object, and Fourier synthesis is the production of the image from the scattered radiation. The “phase problem” expresses our inability to devise an apparatus for exploring the relative phases of diffracted X‐ray beams.
Cumene hydroperoxide (CuOOH) inactivated cytochrome P450 2B1: Identification of an active site heme-alkylated peptide (1992)

CuOOH-mediated inactivation of P450s results in their prosthetic heme degradation to products that alkylate the apoprotein. Indirect approaches suggest that this alkylation occurs at the active site. To identify the specific apoprotein site(s) alkylated, purified {sup 3}H-or {sup 14}C-heme labeled P450 2B1 incubated with CuOOH, was subjected to lysyl endopeptidase-C digestion. Two major peaks (L1 and L2) containing {sup 3}H- or {sup 14}C-labeled peptides were detected by reverse-phase HPLC of the digest (C4 column; linear solvent gradient: 15 to 85% B (iPrOH:acetonitrile, 1:1; 0.08% HFBA)/120 min; A (H{sub 2}O/0.1% HFBA)). L1 (eluting at {approx} 65% solvent B) contained the highest specific radioactivity and after tricine-SDS PAGE yielded 3 peptide bands (MW {approx} 3,000 (P1), 5,000 (P2) and 8,000 (P3)). Although all 3 bands were found radiolabeled, the yield of P1 was higher than that of P2 or P3. Amino acid (AA) sequence analysis of the first 13 N-terminal residues of P1 revealed the sequence RICLGEGIARNEL, corresponding to residues 434-446 of the reported 2B1 sequence. A peptide with the molecular mass of 3,771 was detected in preliminary electrospray mass spectrometric analysis of L1. Since the mass calculated for the AA composition of the predicted peptide (434-466) is 3,722, the additional 49more » mass units apparently are contributed by the alkylating heme fragment. This alkylated 2B1 sequence contains Cys{sub 436}, the conserved residue that provides the SH-ligand for heme, and therefore corresponds to the heme-sandwiching helix L of P450 101. Thus, these findings indicate the heme alkylation occurs at the 2B1 active site, thereby qualifying the process as truly suicidal.« less
Verdinexor (KPT-335), a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication <i>In Vitro</i> (2018)

Respiratory syncytial virus (RSV) is a leading cause of hospitalization of infants and young children, causing considerable respiratory disease and repeat infections that may lead to chronic respiratory conditions such as asthma, wheezing, and bronchitis. RSV causes ∼34 million new episodes of lower respiratory tract illness (LRTI) in children younger than 5 years of age, with >3 million hospitalizations due to severe RSV-associated LRTI. The standard of care is limited to symptomatic relief as there are no approved vaccines and few effective antiviral drugs; thus, a safe and efficacious RSV therapeutic is needed. Therapeutic targeting of host proteins hijacked by RSV to facilitate replication is a promising antiviral strategy as targeting the host reduces the likelihood of developing drug resistance. The nuclear export of the RSV M protein, mediated by the nuclear export protein exportin 1 (XPO1), is crucial for RSV assembly and budding. Inhibition of RSV M protein export by leptomycin B correlated with reduced RSV replication <i>in vitro</i> In this study, we evaluated the anti-RSV efficacy of Verdinexor (KPT-335), a small molecule designed to reversibly inhibit XPO1-mediated nuclear export. KPT-335 inhibited XPO1-mediated transport and reduced RSV replication <i>in vitro</i> KPT-335 was effective against RSV A and B strains and reduced viral replication following prophylactic or therapeutic administration. Inhibition of RSV replication by KPT-335 was due to a combined effect of reduced XPO1 expression, disruption of the nuclear export of RSV M protein, and inactivation of the NF-κB signaling pathway.<b>IMPORTANCE</b> RSV is an important cause of LRTI in infants and young children for which there are no suitable antiviral drugs offered. We evaluated the efficacy of KPT-335 as an anti-RSV drug and show that KPT-335 inhibits XPO1-mediated nuclear export, leading to nuclear accumulation of RSV M protein and reduction in RSV levels. KPT-335 treatment also resulted in inhibition of proinflammatory pathways, which has important implications for its effectiveness <i>in vivo</i>.
Tolerating Multiple Failures in RAID Architectures with Optimal Storage and Uniform Declustering (2009)

<P>We present DATUM, a novel method for tolerating multiple disk failures in disk arrays. DATUM is the first known method that can mask any given number of failures, requires an optimal amount of redundant storage space, and spreads reconstruction accesses uniformly over disks in the presence of failures without needing large layout tables in controller memory. Our approach is based on information dispersal, a coding technique that admits an efficient hardware implementation. As the method does not restrict the configuration parameters of the disk array, many existing RAID organizations are particular cases of DATUM. A detailed performance comparison with two other approaches shows that DATUM's response times are similar to those of the best competitor when two or less disks fail, and that the performance degrades gracefully when more than two disks fail.</P>
Experimental study on elimination of bursting of natural coke in YongXia coalfield (2012)

Because of its special geological environment,natural coke formation has special bursting,resulting in the decrease of stability and availability.The purpose of this experiment is to identify ways of elimination of bursting of natural coke.According to the physical and chemical properties and process performance,high-temperature method and fragmentation method were chosen in the test.From the results,the high temperature method process is relatively complex,and the fragmentation method is relatively simple.After elimination of the thermal explosion,natural coke as fuel could be used in power generation,steel industry,foundry and civilian.It also could be used in gasification,activated carbon and calcium carbide as chemicals.
A Systematic Literature Review of Data Privacy Issues in Cloud BI (2021)

Cloud Business Intelligence (Cloud BI) can provide a competitive advantage to businesses, but it also has implications for data security and privacy. Leakage of sensitive data can cause serious impacts on the credibility of a company and result in financial as well as trust losses. Therefore, it is especially important to discuss the data security and privacy issues of Cloud BI. This study uses a systematic literature review to understand Cloud BI security. The results show that internal and external organisational factors have an impact on Cloud BI privacy. This paper also explored the security issues in cloud computing and found similarities and differences between cloud computing and Cloud BI. The findings of the research have applied and theoretical significance and will help organisations in successfully implementing Cloud BI security with a layered approach, which is discussed in the study.
Coaxial Feed Pyramidal Horn Antenna with High Efficiency (2017)

In this paper, a short pyramidal horn antenna with coaxial feed has been designed and fabricated with 52% bandwidth, which covers CDMA and GSM 900 bands. The total length of the antenna including coaxial feed is approximately 0.85λ at the lowest usable frequency. The effect of coaxial probe length, probe radius, and its location from the short wall of the waveguide on the resonance frequency, impedance matching, and bandwidth of the horn antenna have been analysed using CST Microwave studio software. Also, parametric analyses have been done by varying the horn length and aperture dimensions to study radiation characteristics of the horn antenna. The horn length has been optimized to obtain maximum efficiency for a fixed aperture. Simulation results show that as the frequency increases from 700 to 1130 MHz, the gain monotonically increases from 8.4 to 12.6 dBi with maximum efficiency of 80% at 850 MHz and it varies between 72% and 80% over this band. The pyramidal horn antenna has been fabricated and measured results are in good agreement with the simulated results.
Domain Compositions and Fullerene Aggregation Govern Charge Photogeneration in Polymer/Fullerene Solar Cells (2014)

The complex microstructure of organic semiconductor mixtures continues to obscure the connection between the active layer morphology and photovoltaic device performance. For example, the ubiquitous presence of mixed phases in the active layer of polymer/fullerene solar cells creates multiple morphologically distinct interfaces which are capable of exciton dissociation or charge recombination. Here, it is shown that domain compositions and fullerene aggregation can strongly modulate charge photogeneration at ultrafast timescales through studies of a model system, mixtures of a low band‐gap polymer, poly[(4,4′‐bis(2‐ethylhexyl)dithieno[3,2‐b:2′,3′‐d]germole)‐2,6‐diyl‐alt‐(2,1,3‐benzothia‐diazole)‐4,7‐diyl], and [6,6]‐phenyl‐C 71 ‐butyric acid methyl ester. Structural characterization using energy‐filtered transmission electron microscopy (EFTEM) and resonant soft X‐ray scattering shows similar microstructures even with changes in the overall film composition. Composition maps generated from EFTEM, however, demonstrate that compositions of mixed domains vary significantly with overall film composition. Furthermore, the amount of polymer in the mixed domains is inversely correlated with device performance. Photoinduced absorption studies using ultrafast infrared spectroscopy demonstrate that polaron concentrations are highest when mixed domains contain the least polymer. Grazing‐incidence X‐ray scattering results show that larger fullerene coherence lengths are correlated to higher polaron yields. Thus, the purity of the mixed domains is critical for efficient charge photogeneration because purity modulates fullerene aggregation and electron delocalization.