gebhart/patrepeval huggingface dataset:
A Three-Gene Expression Signature Model for Risk Stratification of Patients with Neuroblastoma (2012)

We propose for the first time in neuroblastoma, a technically simple PCR-based predictor model that could help refine current risk stratification systems.
Textual paralanguage and its implications for marketing communications (2016)

Abstract Both face‐to‐face communication and communication in online environments convey information beyond the actual verbal message. In a traditional face‐to‐face conversation, paralanguage, or the ancillary meaning‐ and emotion‐laden aspects of speech that are not actual verbal prose, gives contextual information that allows interactors to more appropriately understand the message being conveyed. In this paper, we conceptualize textual paralanguage (TPL), which we define as written manifestations of nonverbal audible, tactile, and visual elements that supplement or replace written language and that can be expressed through words, symbols, images, punctuation, demarcations, or any combination of these elements. We develop a typology of textual paralanguage using data from Twitter, Facebook, and Instagram. We present a conceptual framework of antecedents and consequences of brands' use of textual paralanguage. Implications for theory and practice are discussed.
Proton Pump (H<sup>+</sup>/K<sup>+</sup>‐ATPase) Expression in Human Laryngeal Seromucinous Glands (2005)

B-3.
Multifunctional All-Dielectric Metasurfaces (2018)

Cascaded dielectric metasurfaces that provide distinct polarization conversion/control at different bands are introduced. A step-by-step design approach is presented to realize a wide range of polarization transformations with metasurfaces employing simple geometries. The proposed metasurfaces consist of cascaded subwavelength gratings with varying orientations that are separated by isotropic spacers. These metasurfaces can be designed to function as broadband or multiband polarization filters, as well as multifunctional polarization converters that are compact (wavelength-scaled)and low-loss.
Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke (2009)

Hemorrhagic stroke is a common cause of permanent brain damage, with a significant amount of the damage occurring in the weeks following a stroke. This secondary damage is partly due to the toxic effects of hemin, a breakdown product of hemoglobin. The serum proteins hemopexin and albumin can bind hemin, but these natural defenses are insufficient to cope with the extremely high amounts of hemin (10 mM) that can potentially be liberated from hemoglobin in a hematoma. The present review discusses how hemin gets into brain cells, and examines the multiple routes through which hemin can be toxic. These include the release of redox-active iron, the depletion of cellular stores of NADPH and glutathione, the production of superoxide and hydroxyl radicals, and the peroxidation of membrane lipids. Important gaps are revealed in contemporary knowledge about the metabolism of hemin by brain cells, particularly regarding how hemin interacts with hydrogen peroxide. Strategies currently being developed for the reduction of hemin toxicity after hemorrhagic stroke include chelation therapy, antioxidant therapy and the modulation of heme oxygenase activity. Future strategies may be directed at preventing the uptake of hemin into brain cells to limit the opportunity for toxic interactions.
Program Plan for the Design and Spin Test of Ceramic Blade-Metal Disk Attachments (1976)

A current NASA-sponsored contract will develop attachment technology for hybrid turbine rotors having dovetailed ceramic ceramic blades and a wrought metal disk. The approach and sequence of activities are described in detail. The program scope includes design, fabrication, and spin testing of hot-pressed silicon nitride blades for operation at rotor inlet temperatures of 2192 F (1200 C) or greater.
Rheological Properties of Poly(dimethylsiloxane) (1998)

Poly(dimethylsiloxane) solutions are widely used in coating mixtures of many industrial coating processes. The flow of these solutions in and around the coating devices is strongly dependent on their rheological properties. This work presents a comprehensive experimental study of these properties. The tests were carried out for two poly(dimethylsiloxane), PDMS, solutions with vastly different viscosities, 1000 and 30 000 mPa·s. The measurements were taken on the RheoStress RS100 rheometer of Haake, over the range of temperatures 10−50 °C. The solutions were tested for steady shear values, thixotropic behavior, transient shear stress response, yield stress values, creep−recovery response, and dynamic response.
Compaction of enteric-coated pellets: influence of formulation and process parameters on tablet properties and in vivo evaluation (2004)

The aim of this study was to investigate the influence of formulation and compression parameters on the properties of tablets, containing enteric-coated pellets, and on the integrity of the enteric polymer of the individual pellets after compression. In addition the piroxicam plasma concentrations were determined after single and multiple oral administration of powder, pellet and tablet formulations at a dose of 0.3 mg piroxicam/kg bodyweight to dogs. Tablets consisted of enteric-coated pellets (containing 2.5% (w/w) piroxicam in combination with microcrystalline cellulose and sodium carboxymethylcellulose (using Avicel PH 101 and Avicel CL 611 in a ratio of 1-3), cushioning waxy pellets and 10% Kollidon CL (as an external disintegrator). From the D-optimality experimental design it was concluded that the ratio of coated pellets to cushioning pellets (CoP/CuP) affected all tablet properties evaluated. Variation of the pellet size and the CoP/CuP ratio resulted in different in vitro tablet disintegration times. Enteric coating of the pellets or compression of the coated pellets did not have a significant influence (P >0.05) on AUC(0-->72 h). Cmax values obtained after oral administration of coated pellets and compressed coated pellets were significantly lower than for the other formulations. Differences in in vitro tablet disintegration times were not reflected in the onset of the piroxicam plasma concentrations. A dosing interval of 48 h prevented piroxicam accumulation following multiple dose administration.
Synthesis of the anionic hydroxypropyl-β-cyclodextrin:poly(decamethylenephosphate) polyrotaxane and evaluation of its cholesterol efflux potential in Niemann–Pick C1 cells (2018)

Niemann-Pick type C disease (NPC) is a lysosomal storage disease that is characterized by a progressive accumulation of unesterified cholesterol in the lysosomes leading to organ damage from cell dysfunction. Hydroxypropyl-β-cyclodextrin (HP-β-CD) is an attractive drug candidate for treating NPC, as it diminishes cholesterol accumulation in NPC cells. Systemic HP-β-CD treatment, however, is limited by rapid renal clearance. We designed a new anionic HP-β-CD polyrotaxane to act as a slow release formulation based on a polyalkylene phosphate core to improve the pharmacokinetics. The polyalkylene phosphate comprises hydrophobic decamethylene spacers linked by biodegradable anionic phosphodiester bonds. HP-β-CD was threaded onto this polymer first and α-CD afterwards to prevent burst release of the threaded HP-β-CD. Our findings show that HP-β-CD was slowly released from the watersoluble polyrotaxane over a 30 days period. The polyrotaxane provided persistently diminished cholesterol levels in NPC1 cells by 20% relative to untreated cells. These results demonstrate the therapeutic potential of this novel HP-β-CD polyrotaxane for the mobilization of aberrantly stored cholesterol in NPC1 cells.
Nymphs of the common bed bug (Cimex lectularius) produce anti-aphrodisiac defence against conspecific males (2010)

By combining behavioural and sensory studies, we show that the nymph-specific alarm pheromone plays an important role in intra-specific communication in the common bed bug. Alarm pheromones are commonly looked upon as a system in predator/prey communication, but here we show that alarm pheromones may be used as multipurpose signals such as decreasing the risk of nymphal mating by males.
Com port based distributed system (2013)

Today Distributed Network Systems are very popular due to incompatibility and uncertainty of centralized network based systems. This paper presents peer to peer distributed system. The designed distributed consists of group of PC terminals as node of distributed system. The tool has been developed which is software computer application that handles the communication between nodes of Distributed Systems. COM port based distributed system comprises with distributed terminals. These terminals are internet worked by using the wired communication network. We designed and developed the software tool which comprises with two computer applications as a program. We have mentioned the pin out diagram of RS232 cable. Paper illustrates that how does the data transmission takes place during the data transfer operations. We have transferred three database files which contains the text data. The performance is measured and analyzed. Paper also contains the advantages, disadvantages of COM Port based distributed system.
Association Study of Trauma Load and<i>SLC6A4</i>Promoter Polymorphism in Posttraumatic Stress Disorder (2010)

We find evidence for a gene-environment interplay for PTSD and show that genetic influences lose importance when environmental factors cause an extremely high trauma burden to an individual. In the future, it may be important to determine whether the effectiveness of therapeutic interventions in PTSD is also modulated by the SLC6A4 genotype.
Windows 7: The Missing Manual (2010)

In early reviews, geeks raved about Windows 7. But if you're an ordinary mortal, learning what this new system is all about will be challenging. Fear not: David Pogue's Windows 7: The Missing Manual comes to the rescue. Like its predecessors, this book illuminates its subject with reader-friendly insight, plenty of wit, and hardnosed objectivity for beginners as well as veteran PC users. Windows 7 fixes many of Vista's most painful shortcomings. It's speedier, has fewer intrusive and nagging screens, and is more compatible with peripherals. Plus, Windows 7 introduces a slew of new features,
Zero Energy Windows (2006)

Windows in the U.S. consume 30 percent of building heating and cooling energy, representing an annual impact of 4.1 quadrillion BTU (quads) of primary energy 1 .Windows have an even larger impact on peak energy demand and on occupant comfort.An additional 1 quad of lighting energy could be saved if buildings employed effective daylighting strategies.The ENERGY STAR program has made standard windows significantly more efficient.However, even if all windows in the stock were replaced with today's efficient products, window energy consumption would still be approximately 2 quads.However, windows can be "net energy gainers" or "zero-energy" products.Highly insulating products in heating applications can admit more useful solar gain than the conductive energy lost through them.Dynamic glazings can modulate solar gains to minimize cooling energy needs and, in commercial buildings, allow daylighting to offset lighting requirements.The needed solutions vary with building type and climate.Developing this next generation of zero-energy windows will provide products for both existing buildings undergoing window replacements and products which are expected to be contributors to zero-energy buildings.This paper defines the requirements for zero-energy windows.The technical potentials in terms of national energy savings and the research and development (R&D) status of the following technologies are presented: Highly insulating systems with U-factors of 0.1 Btu/hr-ft-F Dynamic windows: glazings that modulate transmittance (i.e., change from clear to tinted and/or reflective) in response to climate conditions Integrated facades for commercial buildings to control/ redirect daylight Market transformation policies to promote these technologies as they emerge into the marketplace are then described.
Neural correlates of epigenesis (2006)

The effect of life stress on depression is moderated by a repeat length variation in the transcriptional control region of the serotonin transporter gene, which renders carriers of the short variant vulnerable for depression. We investigated the underlying neural mechanisms of these epigenetic processes in individuals with no history of psychopathology by using multimodal magnetic resonance-based imaging (functional, perfusion, and structural), genotyping, and self-reported life stress and rumination. Based on functional MRI and perfusion data, we found support for a model by which life stress interacts with the effect of serotonin transporter genotype on amygdala and hippocampal resting activation, two regions involved in depression and stress. Life stress also differentially affected, as a function of serotonin transporter genotype, functional connectivity of the amygdala and hippocampus with a wide network of other regions, as well as gray matter structural features, and affected individuals' level of rumination. These interactions may constitute a neural mechanism for epigenetic vulnerability toward, or protection against, depression.
Comparing performance of the Learnable Evolution Model and genetic algorithms (1999)

This paper describes an application of the Learnable Evolution Model (LEM) to a digital signal filter parameter identification problem and compares its performance to genetic algorithm solutions.
ChemInform Abstract: Kinetic Resolution of 1‐Methyl‐1‐phenylpropyl Hydroperoxide via Sharpless Epoxidation. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thermodynamic model for electrical tree propagation kinetics in combined electrical and mechanical stresses (2005)

In this paper we develop a kinetic model for the growth of electrical tree structures in solid polymeric insulation that allows for combined electrical and mechanical stresses. We present an energy balance analysis during the tree growth process and show the total tree extension driving force is not a material constant due to the existence of a damage process zone around the tree tip and the dissipated heat and the trapped energy remaining in the damage process zone. We derive both the tree growth rate equation and life formula of tree propagation to breakdown, based on the specific tree growth mechanism and the fractal nature of tree structures. We perform electrical tree growth tests in epoxy resin samples with and without mechanical residual stresses, and present results which show that the proposed model can give predicted tree propagation times to failure in good agreement with the experimental data of the tree growth subjected to a combined electrical and mechanical stress
Teenage pregnancy summary 2013 (2012)

The pregnancy project sought to expose the existence, and challenge the validity, of stereotypes about Hispanic women. The charade explored the underlying motivations of the many who responded with a wide range of reactions. The specific objectives of this regional study are: to establish a thorough description of the magnitude of the issue and its potential implications for social advancement; to advance the understanding of the risk factors, motivations and impacts at the household level-as a determinant of poverty and a cause of intra-and intergenerational poverty traps; to illuminate the coping mechanisms and their individual and social implications; to highlight the gender-related issues that have historically provoked asymmetric costs to boys and girls; and to provide elements that support specific policies on this matter. In the last decade, Latin America and the Caribbean (LAC) have been moving in the right direction and the region has experienced important gains in gender equality of endowments (assets) and economic opportunities. In most LAC countries, girls have been achieving gender parity in primary school enrollment and even outperforming boys at the secondary and tertiary level. The present report reviews the factors associated with teenage pregnancy and early childbearing and builds a framework to explore these issues systematically, towards the design of effective policy interventions in LAC. Teen pregnancy and early childbearing remain a challenge in the region, particularly given the association of these phenomena with poverty and lack of opportunities, and the concern that it may prevent women from taking full advantage of their human development assets and opportunities. The main message of the report is that poverty and lack of opportunities are key factors associated to early childbearing.
The role of sex hormones in systemic lupus erythematosus (1999)

The disease systemic lupus erythematosus (SLE) is a complex one. One major clinical manifestation that relates to both cause and pathogenesis of all autoimmune diseases but specifically SLE is the sexual predilection for females. A consideration of mechanisms for this manifestation is the subject of this paper. The cytokine network is a major aspect of immune regulation and directly affected by sex steroids. The sexual dimorphism of the immune system relates to both organ-specific and general synthesis of sex steroids that are affected by and in turn affect cytokine profiles of T helper cells. There are also specific responses in cells from diseased patients that support the molecular activities of sex hormones on cells. Among these is the rise of calcineurin mRNA in SLE T cells in response to estrogen. Clinical research provides support for a more estrogenic environment in patients with SLE of both sexes. A preferential hydroxylation of estrone and increased oxidation of testosterone in patients with SLE maximizes the effects of estrogens on T cell functions. The effects of gonadotrophins like prolactin are discussed as stimulants of immune functions when elevated in SLE. Last, while the roles of exogenous estrogens on immune functions are known, the effects of such steroids alone or in combination with progestogens on SLE are not known. Investigation of both hormone replacement therapy and premenopausal hormone use are in progress.
Neurotoxins targetting receptor site 5 of voltage-dependent sodium channels increase the nodal volume of myelinated axons (1999)

The effects of a C57 type ciguatoxin (CTX-3C) and two types of brevetoxins (PbTx-1 and PbTx-3), known to bind to receptor site 5 of the neuronal voltage-dependent Na+ channel-protein, were studied on the morphology of living frog myelinated axons using confocal laser scanning microscopy. During the action of CTX-3C, PbTx-1, and PbTx-3 (10-50 nM), a marked swelling of nodes of Ranvier was observed without apparent modification of internodal parts of axons. In all cases, toxin-induced nodal swelling attained a steady-state within 75-100 min that was well maintained during an additional 90-115 min. The nodal swelling was reversed by an external hyperosmotic solution containing 100 mM D-mannitol and could be completely prevented by blocking voltage-dependent Na+ channels with 1 microM tetrodotoxin. It is suggested that CTX-3C, PbTx-1, and PbTx-3 by activating Na+ channels cause a continuous Na+ entry into axons, increasing internal Na+ concentration. Such an increase directly or indirectly disturbs the osmotic equilibrium between intra- and extra-axonal media, resulting in an influx of water, which is responsible for the long-lasting nodal swelling. Similar results were previously reported with two C60 type ciguatoxins (CTX-1B and CTX-4B). Thus, it is concluded that the four types of toxins targetting receptor site 5 of neuronal voltage-dependent Na+ channels, not only enhance nerve membrane excitability but also, on a long-term basis, cause a marked increase in the axonal volume.
Performance of hierarchical multiplexing in ATM switch design (2003)

The authors study the delay-throughput characteristics and the buffer requirements associated with hierarchical multiplexing for random and bursty traffic models. The interface data rates to the external lines can be and usually are different from the internal core fabric speed of an asynchronous transfer mode (ATM) switch. As signals are multiplexed inside the switch to higher speeds, the required dimension of the core fabric is reduced, leading to a reduction in physical size, easing of input/output constraints, simpler control, and improved hardware efficiency. The simulation results, for random and bursty traffic models, indicate that this hierarchical multiplexing technique has little impact on the delay-throughput performance. The results also show that a small degree of multiplexing dramatically increases the buffer requirements. However, further multiplexing reduces the amount of buffering down to more acceptable levels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Monte Carlo model of photon beams used in radiation therapy (1995)

A generic Monte Carlo model of a photon therapy machine is described. The model, known as McRad, is based on EGS4 and has been in use since 1991. Its primary function has been the characterization of the incident photon fluence for use by dose calculation algorithms. The accuracy of McRad is examined by comparing the dose distributions in a water phantom generated using only the Monte Carlo data with measured dose distributions for two machines in our clinic; a 6 MV Varian Clinac 600C and the 15 MV beam from a Clinac 2100C. The Monte Carlo generated dose distributions are computed using a dose calculation algorithm based on the use of differential pencil beam kernels. It was found that the match to measured data could be improved if the model is tuned by adjusting the energy of the electron beam incident on the target. The beam profiles were found to be more sensitive indicators of the electron beam energy than the depth dose curves. Beyond the depths reached by contaminant electrons, the computed and measured depth dose curves agree to better than 1%. The comparison of beam profiles indicate that in regions up to within 1 cm of the field edge, the measured and computed doses generally agree to within 2%-3%.
Pd(OAc)<sub>2</sub>-Catalyzed Carbonylation of Amines (2006)

A phosphine-free catalytic system [Pd(OAc)2-Cu(OAc)2-air] induced a substrate-specific carbonylation of amines in boiling toluene under CO gas (1 atm). Symmetrical N,N'-dialkylureas were obtained by the carbonylation of primary amines. N,N,N'-Trialkylureas were selectively formed by addition of a secondary amine to the above reaction vessel. Secondary amines did not give tetraalkylureas. However, dialkylamines with a phenyl group on their alkyl chains, such as N-monoalkylated benzylic amine or phenethylamine derivatives, underwent a direct aromatic carbonylation to afford five- or six-membered benzolactams. In the carbonylation, the chelation effect or steric repulsion between Pd(II) and the meta-substituent in the ortho-palladation and the ring sizes of cyclopalladation products that were formed prior to carbonylation were found to generate good site selectivity and increase the reaction rate. In contrast, carbonylation of omega-arylalkylamines with a hydroxyl group gave neither ureas nor benzolactams but instead produced 1,3-oxazolidinones smoothly. Hydrochlorides of amines also underwent carbonylation to afford the corresponding amides under the conditions used. This procedure made it possible to prepare ureas of amino acid esters and N-alkylcarbamates in practical yields.