gebhart/patrepeval huggingface dataset:
Luminescence study of defects in synthetic as-grown and HPHT diamonds compared to natural diamonds (2005)

The optically active defects in as-grown, high-pressure high-temperature-treated (HPHT), borondoped, and synthetic diamonds (SD) grown with a nitrogen-getter, as well as of natural diamonds (ND), were characterized by absorption and luminescence spectroscopies using different excitation sources. The laser-excited photoluminescence (PL) spectra of SDs show numerous sharp lines characteristic for nickel-related centers, whereas NDs yield mainly broad PL bands. The emission from the nickel-related defects in NIR range increases and the maxima of the bands shift to lower energies with increasing temperature. Under UV and electron beam excitation, the yellow synthetic diamonds display green luminescence patterns along octahedral directions. The UV-excited PL spectra of the yellow SDs show a green band associated with nickel-related optical species. NDs display broad bands centered at ca. 450 nm that are related to complex nitrogen-related aggregates formed in the mantle in a long period of geological time. The cathodoluminescence (CL) spectra of SDs reveal many nickel-related and simple nitrogen-vacancy defects. Differences among as-grown, HPHT, and boron-doped diamonds can be observed. The CL bands of NDs are partly formed or caused by complicated nitrogen aggregates, like N3 and N4 centers. The CL band of NDs shifted from blue to green with increasing irradiation time. The deep-UV (DUV) excited time resolved PL spectra of NDs showed fast-decaying donor-acceptor pair recombination (DAPR) bands at around 410 nm. With longer delay and gate times, the broad band shifted to ca. 435 nm. All synthetic diamonds display luminescence from nickel-related defects centered at ca. 480 and 530 nm at room temperature (RT) and 77 K, respectively, and all SDs had a sharp luminescence band at 694 nm due to a Cr3+ impurity in corundum inclusions.
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics (2018)

Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates remain less than 15%. A lack of experimental models has hampered progress. We have generated clinically annotated EAC organoid cultures that recapitulate the morphology, genomic, and transcriptomic landscape of the primary tumor including point mutations, copy number alterations, and mutational signatures. Karyotyping of organoid cultures has confirmed polyclonality reflecting the clonal architecture of the primary tumor. Furthermore, subclones underwent clonal selection associated with driver gene status. Medium throughput drug sensitivity testing demonstrates the potential of targeting receptor tyrosine kinases and downstream mediators. EAC organoid cultures provide a pre-clinical tool for studies of clonal evolution and precision therapeutics.
MULTIPROCESSING HW/SW Recent Experience on an ESL Framework for Rapid Design Exploration using Hardware-Software Codesign for ARM-based FPGAs (2012)

This paper presents an Electronic System Level (ESL) framework for the system specification, hardware/software (HW/SW) co-design and rapid design space exploration of electronic systems subject to Quality of Results (QoR) constraints such as performance, area and power. This framework is based on recent standards such as SystemC TLM-2.0 and IEEE 1685 (IP-XACT), and is enabled by the SpaceStudio TM tool suite, which incorporates novel research in virtual platform modeling, performance profiling and HW/SW co-design. The framework is demonstrated on a Motion-JPEG (M-JPEG) video decoder. We rapidly specified and evaluated 26 architectures and 14 power/performance trade-offs for the M-JPEG targeting the Xilinx Zynq platform, which combines an FPGA fabric and an ARM Cortex-A9 dual-core processor. These architectures used up to 2 of the ARM’s cores as well as 0 to 2 MicroBlaze soft-core processors, running with either bare-metal embedded software or the µCOS/II RealTime Operating System (RTOS), and differing in their HW/SW partitioning of application tasks. We show how the best architecture selection depends on the performance, area and power constraints.
The selective mu‐opioid receptor antagonist adl5510 reduces levodopa‐induced dyskinesia without affecting antiparkinsonian action in mptp‐lesioned macaque model of Parkinson's disease (2011)

In Parkinson's disease (PD), dyskinesia develops following long-term treatment with 3,4-dihydroxyphenylalanine (L-dopa). Given the prominent role of the opioid system in basal ganglia function, nonselective opioid receptor antagonists have been tested for antidyskinetic efficacy in the clinic (naltrexone and naloxone), although without success. In the current study, ADL5510, a novel, orally active opioid antagonist with mu opioid receptor selectivity, was examined in L-dopa-treated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) macaques. Antidyskinetic effects were compared with those of naltrexone. Parkinsonian monkeys with established L-dopa-induced dyskinesia (LID) received acute challenges with L-dopa (subcutaneously) in combination with either vehicle, ADL5510 (0.1, 1, 3 or 10 mg/kg by mouth), or naltrexone (1, 3, or 10 mg/kg subcutaneously). Following treatments, behavior was monitored for 6 hours. Parameters assessed were total activity, parkinsonism, and dyskinesia. ADL5510 (1, 3, and 10 mg/kg) reduced activity and LID (chorea and dystonia) without affecting the antiparkinsonian benefits of L-dopa. The antidyskinetic effect of ADL5510 showed a U-shaped dose-response. It was inactive at 0.1 mg/kg, efficacious at 1 and 3 mg/kg (72% and 40% reductions, respectively), and then less effective at 10 mg/kg. The quality of ON time produced by L-dopa was improved, as indicated by a reduction in the percentage of ON time spent experiencing disabling dyskinesia (70% and 61% reductions with 1 and 3 mg/kg, respectively, compared with L-dopa). Naltrexone, in contrast, did not alleviate LID or affect the antiparkinsonian actions of L-dopa. Mu-selective opioid antagonists have the potential to form the basis of novel antidyskinetic therapies for PD.
L-Arginine-induced current in portal venous smooth muscle cells (2007)

In our previous report, we showed that L-arginine induced depolarization of smooth muscle cells of the rat portal vein with an increased contraction. To clarify the ionic mechanism of the membrane depolarization, the effect of L-arginine on the holding current was studied in freshly isolated smooth muscle cells of the rat portal vein. The whole-cell patch-clamp technique was used, with the membrane potential held at -60 mV. In the presence of Na+ in the perfusate, L-arginine 10 mM induced an inward current in about 50% of the cells. In Na+-deficient perfusate, L-arginine 10 mM increased the amplitude of the inward current in a Na+ concentration-dependent manner. BCH, an inhibitor of the Na+-dependent amino acid transporter, ceased the L-arginine-induced current. These results indicate that L-arginine induces an inward current via Na+-dependent mechanisms in rat portal venous smooth muscle cells.
Left Ventricular Performance in Ischemic Right Ventricular Dysfunction (2000)

Brookes et al 1 reported decreased left ventricular (LV) systolic performance during right ventricular (RV) ischemia in the pig and concluded that "The hemodynamic compromise seen in association with acute RV dilatation within an intact pericardium is partly attributable to impaired LV systolic performance and cannot be wholly ascribed to changes in either LV preload or compliance." They also stated that ". . . no studies to date have examined LV systolic performance in this context."
Audio Tagging with Noisy Labels and Minimal Supervision (2019)

This paper introduces Task 2 of the DCASE2019 Challenge, titled "Audio tagging with noisy labels and minimal supervision". This task was hosted on the Kaggle platform as "Freesound Audio Tagging 2019". The task evaluates systems for multi-label audio tagging using a large set of noisy-labeled data, and a much smaller set of manually-labeled data, under a large vocabulary setting of 80 everyday sound classes. In addition, the proposed dataset poses an acoustic mismatch problem between the noisy train set and the test set due to the fact that they come from different web audio sources. This can correspond to a realistic scenario given the difficulty of gathering large amounts of manually labeled data. We present the task setup, the FSDKaggle2019 dataset prepared for this scientific evaluation, and a baseline system consisting of a convolutional neural network. All these resources are freely available.
Epidermal growth factor receptor mutation enhances expression of vascular endothelial growth factor in lung cancer (2016)

Epidermal growth factor receptor (EGFR) activation has been demonstrated to have a critical role in tumor angiogenesis. In the present study, the correlation between EGFR mutations and vascular endothelial growth factor (VEGF) was investigated in lung cancer cell lines and non-small-cell lung cancer (NSCLC) tumor tissues. VEGF levels were significantly increased in culture medium of lung cancer cells and NSCLC tissues with EGFR mutations (H1650 vs. A549, P=0.0399; H1975 vs. A549, P<0.0001). Stable lung cancer cell lines expressing mutant (exon 19 deletion, E746-A750; exon 21 missense mutation, L858R) and wild-type EGFR genes were established. Significantly increased expression of VEGF and stronger inhibitory effects of gefitinib to VEGF expression were observed in exon 19 deletion stable lung cancer cells (exon 19 deletion vs. wild-type EGFR, P=0.0005). The results of the present study may provide an insight into the association of mutant EGFR and VEGF expression in lung cancer, and may assist with further development of targeted therapy for NSCLC in the future.
NARRATIVAS POLÍTICAS EDUCACIONAIS INCLUSIVAS: COMPROMISSO DE QUEM, COM QUEM E PARA QUEM? (2020)

O presente trabalho é fruto de questionamentos cotidianos realizados pelas autoras que atuam diretamente no universo escolar tanto na coordenação da educação inclusiva com alunos do ensino fundamental, quanto no ensino superior em instituições públicas e particulares de ensino. Tem por finalidade problematizar a prática inclusiva no universo escolar levando o cenário legal da inclusão. Reconhecendo que o movimento pela garantia de direitos essenciais a todos ainda é recente no Brasil e que, pensar em direitos de todos e para todos historicamente é travado por pressões sociais, sejam elas, conservadoras ou emancipadoras, ainda vivemos um período de transformações em prol da inclusão educacional. As políticas públicas educacionais cumprem uma função ideológica clara na manutenção da ordem capitalista e, que no período em que a presença de pessoas com deficiência e ou necessidade educacionais especiais representava um obstáculo à acumulação do capital, criaram-se as bases para que estas fossem mantidas à margem do convívio social, consequentemente, as instituições especializadas foram de grande serventia cumprindo com a função que lhes foi destinada para receber esses sujeitos excluídos. O avanço legislativo foi alcançado com a militância e o amadurecimento social democrático.Palavras-Chave: Inclusão Educacional. Compromisso Social. Exclusão. Prática Inclusiva
A Decade of CRISPR Gene Editing in China and Beyond: A Scientometric Landscape (2021)

Since its Nobel Prize-winning breakthrough in 2012, CRISPR-Cas-based gene-editing system has emerged as one of the most promising biotechnologies in decades. In this article, we present an objective and comprehensive evaluation of CRISPR-based gene-editing technologies, including base editing and prime editing, based on the bibliometric analysis of 22,902 published records. We also assessed the status of CRISPR gene-editing technologies in academia from 2010 to 2020 globally, with respect to countries, institutions, and researchers, and used text clustering methods to assess technical trends and research hotspots. Our results indicate, not surprisingly, that this is a thriving and prominent area of research. By comparing the relevance and growth of CRISPR gene-editing technologies in China with other countries by several metrics, we show that the Chinese scientific community attaches considerable importance to the field of plant genome engineering, with more scholars from agricultural sectors than other sectors.
O 14 de Infantaria (2009)

Grupo Visabeira; Governo Civil de Viseu; Câmara Municipal de Viseu; Governo Civil da Guarda
Refractive beam steering (2004)

A number of concepts using the principle of the refraction of light have been developed to steer light beams. Refractive beam steering concepts involve the use of optical wedges in order to deviate a light beam. This principle is ideally suited for steering laser light since dispersion is minimal due to the monochromatic nature of the laser. The methods used to form the optical wedge and the means developed to adjust it are what distinguish the various concepts and have resulted in many patents over the years for their innovators. A new concept called a Lubricated Adjustable Optical Wedge (LAOW) has been recently developed that does not require complicated mechanical systems to form the wedge and provide the adjustment necessary to deviate the light beam. An optical wedge is formed using plano-convex and plano-concave lenses that are contacted together using a thin film of transparent index matching lubricant between the spherical surfaces. The forces of capillary action and surface tension provide the sole means of keeping the lens elements together. This technique has demonstrated a repeatability ≤±0.12 arc seconds in beam deviation angle.
Characterization of a new monoclonal antibody to triplex DNA and immunofluorescent staining of mammalian chromosomes. (1994)

A monoclonal antibody, Jel 466, was prepared from mice immunized with poly[d(Tm5C)].poly[d(GA)]. The binding of Jel 466 to nucleic acids was characterized by solid phase radioimmunoassays and competition experiments. There was no binding to single-stranded DNAs or to duplexes which could not form triplexes. In addition, the antibody preferred the triplex form of poly[d(TC)].poly[d(GA)]; it bound weakly to the triplex derived from poly[d(G)].poly[d(C)], but there was no interaction with poly[d(T)].poly[d(A)].poly[d(T)]. This pattern of specificity is very different from that of Jel 318, a triplex-specific antibody that will bind to poly[d(T)].poly[d(A)].poly[d(T)]. The amino acid sequence of Jel 466 also showed very little homology with Jel 318, although both contain many positively charged amino acids. The immunofluorescent staining of mouse and human chromosomes with Jel 466 was studied. In all cases, there was a marked reciprocal relationship between the pattern of Jel 466 on the one hand and that of Hoechst 33258 and Jel 318 on the other. Jel 466 was negative for C-band and G-band but positive for R-band, whereas the opposite was found for Hoechst and Jel 318. Since C and G-bands are AT-rich and R-bands are GC-rich, these staining patterns match the sequence preferences of the two antibodies. Thus the base composition of triplex-forming DNA differs from domain to domain.
Monitoring Serum Tryptic Activity and Effect of Trypsin Inhibitor on Rat Acute Pancreatitis (1994)

The effect of a novel synthetic trypsin inhibitor, 4-(2-succinimidoethylthio)-phenyl 4-guanidinobenzoate methanesulfonate (E3123), on severe acute pancreatitis was studied in trypsin-taurocholate-induced acute experimental pancreatitis in rats. Rats were divided into four groups according to difference of subdivided doses of E3123 with fixing the total dose at 3 mg/kg body weight. Group A: 1.5 mg/kg of E3123 subcutaneously (SC) each at 1 h before and after induction of pancreatitis. Group B: 1 mg/kg SC each at 1 h before, 1 and 3 h after induction. Group C: 1.5 mg/kg SC each at 1 and 3 h after induction. Group D: 1.5 mg/kg SC each at 3 and 5 h after induction of pancreatitis. The survival rate at 24 h was significantly improved in group B (77% in group B, vs. 36% in paired control; p < 0.01) and in group C (70 vs. 38%; p < 0.05), but not in group A or D. Residual tryptic activity of serum alpha 2-macroglobulin trypsin complex (alpha 2M-TRY) was reduced after the injection of E3123 though immunoreactive trypsin remained unchanged in the early phase of pancreatitis. The reduction of alpha 2M-TRY reflected the inhibitory capacity of E3123 in plasma. E3123 showed favorable effects on the initial stage of severe acute pancreatitis and the effects were probably based on the inhibition of alpha 2M-TRY activity in serum.
Spoilers For Stimulated Self-Burial Of Submarine Pipelines (1986)

ABSTRACT Full-scale laboratory tests on a 20" O.D. pipeline with a pair of 5" spoilers show a tremendous increase in local scour as compared to a plain pipeline, indicating a strong self-burialpotential. INTRODUCTION Spoilers on pipelines cause an increase of local turbulence and thus stimulate local sediment pick-up. As a result, the pipeline settles in its self-made trench and may be completely covered afterwards by natural backfill. In previous papers [I, 2] the concept of spoilers for stimulated self-burial of submarine pipelines has been introduced (patents pending), and an explanation of the pipeline burial process was given in terms of alternating "tunnel-erosion" and "leeside erosion".The concept was validated by small-scale laboratory tests. Stimulated self-burial may be applied where the sediment transportability under the given hydraulic conditions meets certain minimum requirements. In these conditions, the new method is much cheaper than artificial trenching. As compared to self-burial of plain pipelines on the other hand, stimulated self-burial significantly increases the speed, the ultimate burial depth, and the area of applicability in terms of sediment characteristics (silty and shelly sand) and hydraulic conditions. As a major step towards a proven, commercially applicable product, an extensive test program was recently started in order to demonstrate the effect of spoilers in full-scale conditions. In this paper, the first results are presented which deal with tunnel-erosion underneath fixed pipelines in uniform flow. TEST SET-UP AND CONDITIONS The aim of the tests was to check whether the previous small-scale test results [1] would be corroborated if carried out at full scale. Therefore the pipeline was conditioned in the same way as before, viz. fixed in between the side panels of a channel with a very small initial gap between the pipe and the sand bed. The tests were carried out in a 100 m long, 3 m wide and 3 m deep channel. Unidirectional flow with a depth-averaged velocity V = 0.60 m/s was applied. There were no waves. Over a length of 75 m a sand bed was present with D50 = 0.22 mm and with a thickness of 1 m. The waterdepth over the sand bed was 1.70 m. The pipeline was installed half-way the sand bed length, perpendicular to the flow direction. First a plain 20" O.D. (0.50 m) pipeline was mounted. The steady current caused tunnel erosion. During the development of the scouring process the bed configuration was monitored by echo sounding in three ranges along the channel, until approximately equilibrium depth was attained. Then,5" (0.125 m) high spoilers were mounted both on top and underneath the pipeline, and the test was continued with the same hydraulic conditions. In this way a good impression can be obtained of the additional scouring potential of spoilers, as compared to the scour caused by a plain pipe.
PLANT COMMUNITY CHANGES WITHIN A MATURE PINYON-JUNIPER WOODLAND (1987)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Movement of the Biotin Carboxylase B-domain as a Result of ATP Binding (2000)

Acetyl-CoA carboxylase catalyzes the first committed step in fatty acid synthesis. In Escherichia coli, the enzyme is composed of three distinct protein components: biotin carboxylase, biotin carboxyl carrier protein, and carboxyltransferase. The biotin carboxylase component has served for many years as a paradigm for mechanistic studies devoted toward understanding more complicated biotin-dependent carboxylases. The three-dimensional x-ray structure of an unliganded form of E. coli biotin carboxylase was originally solved in 1994 to 2.4-A resolution. This study revealed the architecture of the enzyme and demonstrated that the protein belongs to the ATP-grasp superfamily. Here we describe the three-dimensional structure of the E. coli biotin carboxylase complexed with ATP and determined to 2.5-A resolution. The major conformational change that occurs upon nucleotide binding is a rotation of approximately 45(o) of one domain relative to the other domains thereby closing off the active site pocket. Key residues involved in binding the nucleotide to the protein include Lys-116, His-236, and Glu-201. The backbone amide groups of Gly-165 and Gly-166 participate in hydrogen bonding interactions with the phosphoryl oxygens of the nucleotide. A comparison of this closed form of biotin carboxylase with carbamoyl-phosphate synthetase is presented.
Securing smart maintenance services: Hardware-security and TLS for MQTT (2015)

Increasing the efficiency of production and manufacturing processes is a key goal of initiatives like Industry 4.0. Within the context of the European research project ARROWHEAD, we enable and secure smart maintenance services. An overall goal is to proactively predict and optimize the Maintenance, Repair and Operations (MRO) processes carried out by a device maintainer, for industrial devices deployed at the customer. Therefore it is necessary to centrally acquire maintenance relevant equipment status data from remotely located devices over the Internet. Consequently, security and privacy issues arise from connecting devices to the Internet, and sending data from customer sites to the maintainer's back-end. In this paper we consider an exemplary automotive use case with an AVL Particle Counter (APC) as device. The APC transmits its status information by means of a fingerprint via the publish-subscribe protocol Message Queue Telemetry Transport (MQTT) to an MQTT Information Broker in the remotely located AVL back-end. In a threat analysis we focus on the MQTT routing information asset and identify two elementary security goals in regard to client authentication. Consequently we propose a system architecture incorporating a hardware security controller that processes the Transport Layer Security (TLS) client authentication step. We validate the feasibility of the concept by means of a prototype implementation. Experimental results indicate that no significant performance impact is imposed by the hardware security element. The security evaluation confirms the advanced security of our system, which we believe lays the foundation for security and privacy in future smart service infrastructures.