gebhart/patrepeval huggingface dataset:
Serial array time slot interchangers and optical implementations (1994)

We consider time slot interchangers (TSIs) which are built from 2/spl times/2 exchange switches and delays and which are useful for time division multiplexed (TDM) systems in telecommunications and pipelined systems such as time multiplexed optical multiprocessors. We formulate a general method for constructing TSIs based on multistage interconnection networks in the space domain via space-to-time mapping. Two types of TSIs, time slot permuters and time slot sorters, are considered. We review the time slot permuter based on the Benes network, and obtain the /spl Lambdaspl tilde/ time slot permuter based on the bit-controlled, self-routing /spl Lambda/ permutation network. The time slot sorter, S/sub N/, is obtained from the Batcher spatial sorting network. The generalized Lambda time slot permuter /spl Lambdasub Nsup q/ is obtained, in an algorithmic approach, by combining the idea of the /spl Lambdaspl tilde/ time slot permuter and Q-way bitonic decomposition (Q=2/sup q/). The numbers of switches, control complexities, and frame delays of these architectures are compared, and the problem of crosstalk in optical implementation is discussed. It is shown that control complexity can be traded against the number of switches.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In vivo demonstration of whole‐brain multislice multispoke parallel transmit radiofrequency pulse design in the small and large flip angle regimes at 7 Tesla (2016)

The B1+ inhomogeneity problem was mitigated efficiently in a multislice near whole-brain coverage protocol in the small and large FA regimes using a rapid slice-specific pulse design algorithm where the pulses were optimized jointly. Magn Reson Med 78:1009-1019, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Circulating plasma serine<sup>208</sup>‐phosphorylated troponin T levels are indicator of cardiac dysfunction (2013)

Heart failure (HF) following myocardial infarction (MI) is characterized by progressive alterations of left ventricular (LV) structure and function, named LV remodelling. Although several risk factors such as infarct size have been identified, HF remains difficult to predict in clinical practice. Recently, using phosphoproteomic technology, we found that serine(208)-phosphorylated troponin T (P-Ser(208)-TnT) decreases in LV of HF rats. Our aim was to determine the performance of P-Ser(208)-TnT as plasma biomarker of HF compared to conventional cardiac biomarkers such as B-type natriuretic peptide (BNP), cardiac troponin I (cTnI), C-reactive protein (CRP) or tissue inhibitor of metalloproteinase I (TIMP-1) measured by x-MAP technology, as well as its capacity to reflect a pharmacological improvement of HF. We observed a significant increase of BNP, TnT and cTnI levels and a significant decrease of P-Ser(208)-TnT and TIMP-1 in the plasma of 2-month-MI rats compared with control rats with no modulation of CRP level. Circulating levels of P-Ser(208)-TnT were shown to be associated with most of the echocardiographic and haemodynamic parameters of cardiac function. We verified that the decrease of P-Ser(208)-TnT was not because of an excess of phosphatase activity in plasma of HF rats. Two-month-MI rats treated with the heart rate reducing agent ivabradine had improved LV function and increased plasma levels of P-Ser(208)-TnT. Thus, circulating phosphorylated troponin T is a highly sensitive biological indicator of cardiac dysfunction and has the potentiality of a new biomarker of HF post-MI, and of a surrogate marker for the efficacy of a successful treatment of HF.
An expression signature at diagnosis to estimate prostate cancer patients’ overall survival (2014)

The expression signature can potentially be used to estimate overall survival time. When validated in future studies, it could be integrated in the routine clinical diagnostic and prognostic procedure of PCa for an optimal treatment decision based on the estimated survival benefit.
Biomarker Panel for Chronic Graft-Versus-Host Disease (2016)

PurposeTo identify diagnostic and prognostic markers of chronic graft-versus-host disease (cGVHD), the major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT).Patients and MethodsUsing a quantitative proteomics approach, we compared pooled plasma samples obtained at matched time points after HCT (median, 103 days) from 35 patients with cGVHD and 18 without cGVHD (data are available via ProteomeXchange with identifier PXD002762). Of 105 proteins showing at least a 1.25-fold difference in expression, 22 were selected on the basis of involvement in relevant pathways and enzyme-linked immunosorbent assay availability. Chemokine (C-X-C motif) ligand 9 (CXCL9) and suppression of tumorigenicity 2 (ST2) also were measured on the basis of previously determined associations with GVHD. Concentrations of the four lead biomarkers were measured at or after diagnosis in plasma from two independent verification cohorts (n = 391) to determine their association with cGVHD. Their pro...
Angiotensin-(1-7): Blood, Heart, and Blood Vessels (2005)

In the past few years, there has been a growing interest in the heptapeptide Angiotensin(Ang)-(1-7), mainly because of its ability to counter regulate many of Ang II actions. Furthermore, heart and blood vessels are important target tissues for Ang-(1-7) formation and actions. The introduction of novel tools, such as the Ang-(1-7) antagonists, A-779 and D-pro7-Ang-(1-7), the Ang-(1-7) agonist AVE 0991, transgenic rats TGR(A-1-7)3292, and use of liposome-encapsulated Ang-(1-7) for evaluating the biochemical and functional role of Ang-(1-7), have produced a great impact in this field of research. Moreover, the recent identification of the Ang-(1-7)-forming enzyme ACE2 and of the Ang-(1-7) receptor Mas will allow important advances in our understanding of the physiological and pathological role of this peptide. In this review, we will discuss the current knowledge concerning the biological effects of Ang-(1-7) in the blood, heart, and blood vessels. In addition, we will highlight the possible applications of agonists of its receptor as therapeutic agents in cardiovascular and related diseases.
Development and Properties of Ultra-High Strength UOE Linepipe (2004)

High-pressure operation through high strength linepipe reduces long distance transportation cost of natural gas. In order to maximize the cost reduction, X120 UOE pipe has been developed. Low C-Mo-B steel with fine-grained lower bainite (LB) microstructure realizes high strength, excellent low temperature toughness and good weldability. The technology was verified in small-scale commercial production or “mini-rolls”. Suitability for use as linepipe was demonstrated through an extensive development program that covers burst test, fracture toughness evaluation, girth welding technology, etc. A demonstration line was successfully constructed using the pipes manufactured in the “mini-rolls”.
Background modeling and subtraction of dynamic scenes (2003)

Background modeling and subtraction is a core component in motion analysis. The central idea behind such module is to create a probabilistic representation of the static scene that is compared with the current input to perform subtraction. Such approach is efficient when the scene to be modeled refers to a static structure with limited perturbation. In this paper, we address the problem of modeling dynamic scenes where the assumption of a static background is not valid. Waving trees, beaches, escalators, natural scenes with rain or snow are examples. Inspired by the work proposed by Doretto et al. (2003), we propose an on-line auto-regressive model to capture and predict the behavior of such scenes. Towards detection of events we introduce a new metric that is based on a state-driven comparison between the prediction and the actual frame. Promising results demonstrate the potentials of the proposed framework.
Diagnostic and Prognostic MicroRNA Biomarkers for Prostate Cancer in Cell-free Urine (2017)

Using two large patient cohorts, we searched for novel prostate cancer biomarkers in urine. We found two new sets of microRNA biomarkers in urine that could accurately predict the presence of prostate cancer and the likelihood of recurrence after prostatectomy. Further studies are needed before an actual clinical test can be developed.
Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug‐Resistant <i>Pseudomonas aeruginosa</i> (2014)

Abstract Multidrug‐resistant opportunistic bacteria, such as Pseudomonas aeruginosa , represent a major public health threat. Antimicrobial peptides (AMPs) and related peptidomimetic systems offer an attractive opportunity to control these pathogens. AMP dendrimers (AMPDs) with high activity against multidrug‐resistant clinical isolates of P. aeruginosa and Acinetobacter baumannii were now identified by a systematic survey of the peptide sequences within the branches of a distinct type of third‐generation peptide dendrimers. Combined topology and peptide sequence design as illustrated here represents a new and general strategy to discover new antimicrobial agents to fight multidrug‐resistant bacterial pathogens.
Light-field acquisition system allowing camera viewpoint and depth of field compositing in post-production (2013)

Traditional film and broadcast cameras capture the scene from a single view point while important creative parameters such as the camera position and orientation, the depth of field, and the 3D parallax when using a 3D camera rig, are burned into the footage during acquisition. To realize artistic effects such as the Matrixor the Vertigo-effect with traditional cameras is a complex task which requires skilled personnel. Within the Matrix-effect the scene itself appears frozen, while a camera movement is simulated by placing dozens of cameras in a mainly horizontal arrangement. The vertigo-effect, however, requires physical movement of the camera which is usually mounted on a dolly and translates towards and backwards from the scene while the zoom and possibly the focus are changed accordingly. Usually, the scene needs to be shot multiple times until the best combination of zoom corrections and dolly movement is found. Against this background, we present a system which allows capturing the light-field of a sequence and thus offers the full creative leeway of changing camera paths and orientation as well as setting the focal plane in post-production. In contrast to previous approaches, the handling of the involved acquisition system is compact and thus suitable for on-set operation. In this paper we describe the associated content production and present first results which underlie the suitability of the approach.
Automatic Generation of Music Thumbnails (2007)

Automatic generation of music thumbnails based on content analysis is important for efficient management and better consumption of digital music. In this paper, a unique method for extracting thumbnails from a song based on structure analysis of the music piece is presented. First, paragraphs in the song with repeated melody are detected; next, vocal portions in the song are identified. With such information, the structure of the song is derived. Then, one or more thumbnails of the song can be selected according to the song structure and heuristic rules. This approach has proved to be effective when tested on a variety of music pieces. It takes only a couple of seconds to process each song. The method was integrated into a music search system. Also, a demo was built based on it, which lets the user instantly view the structure and thumbnails of any song he selects.
Diffraction Imaging Using Plane-wave Destructor Filters in Common-depth Specularity Gathers (2013)

Seismic diffraction imaging is recognized as a rapidly emerging technology with great potential to reduce exploration and production risks and increase recovery, for conventional reservoirs as well as unconventional resources such as shale gas. The idea behind diffraction imaging in a pre-stack migration framework is to apply a weight factor inside the migration loops, which attenuates events that satisfy Snell's law of specular reflection, while preserving diffractive events that do not satisfy Snell's law. Here we further develop an approach, called specularity gathers, to construct the weight factor in a very efficient way. We introduce a method to filter the specular energy from specularity gathers in order to obtain diffraction images. The use of a filter like plane-wave destructor enables an automatic algorithm, but leaves the option for interactive updates based on interpretation input as well. Further development of this method will help in advancing diffraction imaging technology.
Sensitivity characterization of a photomultiplier tube for terahertz radiation (2021)

In this work, we present the first sensitivity characterization of a photomultiplier tube (PMT) for the detection of terahertz (THz) radiation. The PMT holds a metasurface-based photocathode that emits electrons via the electron field emission effect. This leads to a very non-linear detector that allows one to see much smaller variations of an incident signal than the absolute signal strength itself. We find that this particular PMT has a detection threshold for a THz pulse of 1 nJ and a detection confidence level of 99.7% within 55 – 250 pJ, depending on the THz pulse energy.
Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys (2015)

Antagonizing glucagon action represents an attractive therapeutic option for reducing hepatic glucose production in settings of hyperglycemia where glucagon excess plays a key pathophysiological role. We therefore generated REGN1193, a fully human monoclonal antibody that binds and inhibits glucagon receptor (GCGR) signaling in vitro. REGN1193 administration to diabetic ob/ob and diet-induced obese mice lowered blood glucose to levels observed in GCGR-deficient mice. In diet-induced obese mice, REGN1193 reduced food intake, adipose tissue mass, and body weight. REGN1193 increased circulating levels of glucagon and glucagon-like peptide 1 and was associated with reversible expansion of pancreatic α-cell area. Hyperglucagonemia and α-cell hyperplasia was observed in fibroblast growth factor 21-deficient mice treated with REGN1193. Single administration of REGN1193 to diabetic cynomolgus monkeys normalized fasting blood glucose and glucose tolerance and increased circulating levels of glucagon and amino acids. Finally, administration of REGN1193 for 8 weeks to normoglycemic cynomolgus monkeys did not cause hypoglycemia or increase pancreatic α-cell area. In summary, the GCGR-blocking antibody REGN1193 normalizes blood glucose in diabetic mice and monkeys but does not produce hypoglycemia in normoglycemic monkeys. Thus, REGN1193 provides a potential therapeutic modality for diabetes mellitus and acute hyperglycemic conditions.
Stoneley waves, radial waves, and method of measuring permeability and electroacoustic constant of saturated porous media (2013)

Abstract A two-mode method of measuring permeability and electroacoustic constant in the course of borehole logging is considered. The first mode is the Stoneley wave with its electroacoustic ratio; the second mode is the radial wave in the formation around the borehole with the electric field it generates. The radial wave enables one to measure the electroacoustic constant and the Stoneley wave, the electroacoustic ratio, linearly dependent on permeability. Using these measurements jointly enables one to find permeability of the porous medium. All formation evaluation can be reduced to an additional measurement of electric conductivity.
Stair negotiation made easier using novel interactive energy-recycling assistive stairs (2017)

Here we show that novel, energy-recycling stairs reduce the amount of work required for humans to both ascend and descend stairs. Our low-power, interactive, and modular steps can be placed on existing staircases, storing energy during stair descent and returning that energy to the user during stair ascent. Energy is recycled through event-triggered latching and unlatching of passive springs without the use of powered actuators. When ascending the energy-recycling stairs, naive users generated 17.4 ± 6.9% less positive work with their leading legs compared to conventional stairs, with the knee joint positive work reduced by 37.7 ± 10.5%. Users also generated 21.9 ± 17.8% less negative work with their trailing legs during stair descent, with ankle joint negative work reduced by 26.0 ± 15.9%. Our low-power energy-recycling stairs have the potential to assist people with mobility impairments during stair negotiation on existing staircases.
A novel separate lateral confinement quantum-well heterostructure laser (2002)

Utilizing separate structures for the lateral confinement of the optical mode and injected carriers, we optimize the overlap of the optical mode with the gain to demonstrate lasers with lower threshold currents than standard ridge waveguide lasers.
Continuous Wave Quantum Cascade Lasers With Reduced Number of Stages (2017)

Experimental data for 15-stage 5.6-μm quantum cascade lasers based on Al0.78In0.22As/In0.69Ga0.31As active region composition are presented. Pulsed slope efficiency, threshold current density, and wall-plug efficiency for a $2.1~\text {mm} \times 10.4~\mu \text{m}$ device with a high reflection-coated back facet were measured to be 1.45 W/A, 3.1 kA/cm2, and 18%, respectively. Corresponding continuous wave values for the same parameters were measured to be 1.42 W/A, 3.7 kA/cm2, and 12%. Demonstrated continuous wave optical power level exceeding 0.5 W per millimeter of cavity length makes quantum cascade lasers with reduced number of stages suitable for high power infrared applications.
Hematoporphyrin-Derived Soluble Porphyrin−Platinum Conjugates with Combined Cytotoxic and Phototoxic Antitumor Activity (2002)

To combine the cytotoxic activity of cisplatin and the phototoxicicity of hematoporphyrin derivatives in the same molecule, hematoporphyrin was derivatized at the two secondary alcohol positions by etherification with oligo- and poly(ethylene glycol) units. The two carboxylic acid groups of the propionate side chains were used to bind platinum fragments. The antiproliferative activity of 35 platinum complexes (0.5, 1, and 5 microM) differing in solubility and type of the platinum fragment and the corresponding porphyrin ligands were studied in tests with TCC-SUP and J82 transitional bladder cancer cells in the dark and after irradiation (lambda = 600-730 nm, 24 J/cm(2)). The most active compounds were found among the porphyrin-platinum conjugates bearing the diammine and (RR/SS)-trans-1,2-diaminocyclohexane ligand. These porphyrin-platinum conjugates, especially the water-soluble species, such as diammine(7,12-bis[1-(poly(ethylene glycol)-750-monomethyl ether-1-yl)ethyl]-3,8,13,17-tetramethylporphyrin-2,18-dipropionato)platinum(II), are promising candidates for the development of a novel type of photosensitizers with intrinsic cytotoxicity, which due to the porphyrin constituent may selectively enrich in tumor tissues.
Functionalizable Self-Assembling Polydiacetylenes and Their Optical Properties (1998)

The most versatile polydiacetylene system reported to date from the perspectives of systematic chemical modification and processability was obtained from γ-radiation polymerization of the alkoxycarbonylmethylurethanes of 9-(N-methyl-N-phenylamino)-5,7-nonadiyn-1-ol. These polymers self-assemble into an acentric array, and they are readily modified by functionalization of their dialkylaniline group. The modified polymers provide examples of materials with interesting second-order nonlinear optical properties and the first case of a rigid-rod polymer that exhibits photofabricated surface relief gratings.
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. (1986)

We have isolated and subcloned three separate segments of human DNA which share strong sequence homology with a previously sequenced gene encoding a type I keratin, K14 (50 kilodaltons). Restriction endonuclease mapping has demonstrated that these three genes are tightly linked chromosomally, whereas the K14 gene appears to be separate. As judged by positive hybridization-translation and Northern blot analyses, the central linked gene encodes a keratin, K17, which is expressed in abundance with K14 and two other type I keratins in cultured human epidermal cells. None of these other epidermal keratin mRNAs appears to be generated from the K17 gene through differential splicing of its transcript. The sequence of the K17 gene reveals striking homologies not only with the coding portions and intron positions of the K14 gene, but also with its 5'-noncoding and 5'-upstream sequences. These similarities may provide an important clue in elucidating the molecular mechanisms underlying the coexpression of the two genes.
A <i>trans</i>‐Selective Hydroboration of Internal Alkynes (2013)

Regel missachtet: Die Stereochemie einer Hydroborierung wird gewöhnlich durch suprafacialen Angriff von Wasserstoff und Bor an der gleichen π-Seite eines Substrats bestimmt. Diese grundlegende Regel der cis-Addition kann jetzt für interne Alkine mit [Cp*Ru(MeCN)3]PF6 (Cp*=η5-C5Me5) als Katalysator gebrochen werden. Die daraus resultierende trans-selektive Hydroborierung ermöglicht die Synthese von E-konfigurierten Alkenylbor-Derivaten.
Inhibition of HIV-1 Replication by Cyclosporine A or Related Compounds Correlates with the Ability to Disrupt the Gag–Cyclophilin A Interaction (1996)

The HIV-1 Gag polyprotein specifically incorporates the cellular peptidylprolyl isomerase cyclophilin A into virions. HIV-1 replication is inhibited by cyclosporine A, an immunosuppressive drug which binds with high affinity to cyclophilin A and precludes interaction with the Gag polyprotein. Using a panel of four drugs, including cyclosporine A, two nonimmunosuppressive analogues of cyclosporine A which bind to cyclophilin A but which cannot form a tertiary complex with the calcium-dependent phosphatase calcineurin, and the structurally unrelated immunosuppressant FK506, we demonstrated that the antiviral effect of cyclosporine A is not due to blockade of calcineurin-mediated signal transduction pathways. Rather, the effectiveness of cyclosporine A and related compounds at inhibiting HIV-1 replication correlates with cyclophilin A-binding affinity and with the ability to disrupt the interaction between cyclophilin A and the HIV-1 Gag polyprotein. These results support the contention that the Gag-cyclophilin A interaction is required for HIV-1 replication.