gebhart/patrepeval huggingface dataset:
Electrochemical Mechanism of Molten Salt Electrolysis from TiO2 to Titanium (2022)

Electrochemical mechanisms of molten salt electrolysis from TiO<sub>2</sub> to titanium were investigated by Potentiostatic electrolysis, cyclic voltammetry, and square wave voltammetry in NaCl-CaCl<sub>2</sub> at 800 °C. The composition and morphology of the product obtained at different electrolysis times were characterized by XRD and SEM. CaTiO<sub>3</sub> phase was found in the TiO<sub>2</sub> electrochemical reduction process. Electrochemical reduction of TiO<sub>2</sub> to titanium is a four-step reduction process, which can be summarized as TiO<sub>2</sub>→Ti<sub>4</sub>O<sub>7</sub>→Ti<sub>2</sub>O<sub>3</sub>→TiO→Ti. Spontaneous and electrochemical reactions take place simultaneously in the reduction process. The electrochemical reduction of TiO<sub>2</sub>→Ti<sub>4</sub>O<sub>7</sub>→Ti<sub>2</sub>O<sub>3</sub>→TiO affected by diffusion was irreversible.
Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5. (1990)

After Ag and/or mitogen stimulation, cloned mouse Th1 and Th2 cells produce different cytokines that contribute to induction of particular B cell isotype responses. In this regard, IL-5 produced by Th2 cells has been shown to enhance IgA synthesis in LPS-triggered splenic (SP) B cell or in unstimulated Peyer's patch (PP) B cell cultures. This raises the possibility that Th2 cells may occur in higher frequency in gut-associated tissues, because B cells in these areas are committed to IgA synthesis. We have used an ELISPOT assay to detect individual T cells producing IFN-gamma or IL-5. For the IL-5 assay, the mAb TRFK-5 and biotinylated TRFK-4 were used in coating and detection, respectively, whereas the mAb R4-6A2 and biotinylated XMG 1.2 were similarly used for enumeration of IFN-gamma-specific spot forming cells (SFC). Specificity of each assay was tested by using Con A-activated, cloned Th1 (H66-61) or Th2 (CDC-25) cells, where the Th1 cells only produced IFN-gamma SFC and the Th2 cells only gave IL-5-specific spots. Further, preincubation of biotinylated TRFK-4 or XMG 1.2 with rIL-5 or IFN-gamma, respectively, abrogated the formation of specific spots when tested with Con A-activated SP CD4+ T cells. Both IFN-gamma and IL-5 were produced de novo, because treatment of T cells with cycloheximide inhibited both IFN-gamma and IL-5 SFC. We have assessed the numbers of T cells spontaneously secreting these cytokines in PP and in lamina propria and intraepithelial lymphocyte (LPL and IEL) populations. Moderate levels of IL-5 SFC occurred in the IEL subset, whereas higher levels existed in the LPL population. Although significant numbers of IFN-gamma SFC (Th1-type) were also seen in LPLs, the frequency of IL-5 SFC was always higher (Th1:Th2 in LPL = 1:3). In IELs, equal numbers of IFN-gamma and IL-5 SFC were seen. Interestingly, CD8+ IEL T cells produced these two cytokines. In contrast, T cells freshly isolated from PP, an IgA inductive site, contained smaller numbers of IL-5- or IFN-gamma-secreting cells and SP T cells had essentially no SFC. When PP or SP T cells were stimulated with Con A, significant and approximately equal numbers of IFN-gamma- and IL-5-producing cells appeared.(ABSTRACT TRUNCATED AT 250 WORDS)
Effects of gradient anisotropy in MRI (1998)

A gradient system is anisotropic if the impulse responses of at least two of the gradient channels, x, y, or z, differ from each other. Such an undesired condition may arise, for example, from differences between the gradient channels with respect to eddy currents or from unbalanced time delays in the electronic components. Depending on the degree of anisotropy, the actual gradient then deviates from the nominal, desired gradient under certain oblique orientations during the transient periods of gradient switching. The adverse consequence is degradation of image quality, such as distortion, ghosting, and blurring. In this paper, a theoretical analysis is given of the basic effects. Furthermore, the implications for the MRI process and possible correction methods are described. The effects of anisotropy are shown experimentally for echo-planar imaging and two-dimensional selective RF excitation with spiral gradient pulses.
Multiple archaeal groups mediate methane oxidation in anoxic cold seep sediments (2002)

No microorganism capable of anaerobic growth on methane as the sole carbon source has yet been cultivated. Consequently, information about these microbes has been inferred from geochemical and microbiological observations of field samples. Stable isotope analysis of lipid biomarkers and rRNA gene surveys have implicated specific microbes in the anaerobic oxidation of methane (AOM). Here we use combined fluorescent in situ hybridization and secondary ion mass spectrometry analyses, to identify anaerobic methanotrophs in marine methane-seep sediments. The results provide direct evidence for the involvement of at least two distinct archaeal groups (ANME-1 and ANME-2) in AOM at methane seeps. Although both archaeal groups often occurred in direct physical association with bacteria, they also were observed as monospecific aggregations and as single cells. The ANME-1 archaeal group more frequently existed in monospecific aggregations or as single filaments, apparently without a bacterial partner. Bacteria associated with both archaeal groups included, but were not limited to, close relatives of Desulfosarcina species. Isotopic analyses suggest that monospecific archaeal cells and cell aggregates were active in anaerobic methanotrophy, as were multispecies consortia. In total, the data indicate that the microbial species and biotic interactions mediating anaerobic methanotrophy are diverse and complex. The data also clearly show that highly structured ANME-2/ Desulfosarcina consortia are not the sole entities responsible for AOM at marine methane seeps. Other microbial groups, including ANME-1 archaea, are capable of anaerobic methane consumption either as single cells, in monospecific aggregates, or in multispecies consortia.
A Person Identification Method Using a Top-View Head Image from an Overhead Camera (2012)

In this paper, we describe a novel image-based person identification task. Conventional face-based person identification methods have a low tolerance for occluded situations, such as overlapping of people in an image. We focus on an image from an overhead camera. Using the overhead camera reduces restrictions on the installation location of the camera and solves the problem of occluded images. First, our method identifies a person area in a captured image by using background subtraction. Then, it extracts four features from the area: (1) body size, (2) hair color, (3) hairstyle, and (4) hair whorl. We apply the four features to the AdaBoost algorithm. Experimental results show the effectiveness of our method.
Control of Her-2 Tumor Immunity and Thyroid Autoimmunity by MHC and Regulatory T Cells (2007)

Immune reactivity to self-antigens in both cancer and autoimmune diseases can be enhanced by systemic immune modulation, posing a challenge in cancer immunotherapy. To distinguish the genetic and immune regulation of tumor immunity versus autoimmunity, immune responses to human ErbB-2 (Her-2) and mouse thyroglobulin (mTg) were tested in transgenic mice expressing Her-2 that is overexpressed in several cancers, and HLA-DRB1*0301 (DR3) that is associated with susceptibility to several human autoimmune diseases, as well as experimental autoimmune thyroiditis (EAT). To induce Her-2 response, mice were electrovaccinated with pE2TM and pGM-CSF encoding the extracellular and transmembrane domains of Her-2 and the murine granulocyte macrophage colony-stimulating factor, respectively. To induce EAT, mice received mTg i.v. with or without lipopolysaccharide. Depletion of regulatory T cells (Treg) with anti-CD25 monoclonal antibody enhanced immune reactivity to Her-2 as well as mTg, showing control of both Her-2 and mTg responses by Treg. When immunized with, Her-2xDR3 and B6xDR3 mice expressing H2(b)xDR3 haplotype developed more profound mTg response and thyroid pathology than Her-2 or B6 mice that expressed the EAT-resistant H2(b) haplotype. In Her-2xDR3 mice, the response to mTg was further amplified when mice were also immunized with pE2TM and pGM-CSF. On the contrary, Her-2 reactivity was comparable whether mice expressed DR3 or not. Therefore, induction of Her-2 immunity was independent of DR3 but development of EAT was dictated by this allele, whereas Tregs control the responses to both self-antigens. These results warrant close monitoring of autoimmunity during cancer immunotherapy, particularly in patients with susceptible MHC class II alleles.
Myocardial Cyclic AMP and Norepinephrine Content in Human Heart Failure (1994)

Impaired production of myocardial cyclic adenosine monophosphate (cAMP) is thought to contribute to contractile dysfunction in end stage heart failure, but myocardial cAMP content has not yet been evaluated in heart failure patients in comparison with controls. We therefore measured the myocardial content of cAMP by radioimmunoassay in endomyocardial biopsies from patients in different stages of heart failure and in controls and correlated it with biochemical and functional parameters. The myocardial content of norepinephrine was determined by HPLC in the same biopsies in order to assess if the myocardium studied was affected by heart failure. Myocardial cAMP (in fmol.microgram-1 non-collagen protein) in 20 patients with heart failure (LVEF: 27 +/- 8%, cAMP: 5.8 +/- 2.0) was unchanged in comparison with eight controls (LVEF: 64 +/- 4.7%, cAMP, 4.9 +/- 2.1). In contrast, myocardial norepinephrine (in pg.microgram-1 non-collagen protein) in the same biopsies was significantly reduced in heart failure (4.0 +/- 3.0) in comparison with the same controls (11.5 +/- 3.0, P < 0.0002). Plasma cAMP in 20 heart failure patients (22.0 +/- 4.2 pmol.l-1) was not different from controls(22.0 +/- 7.8), whereas plasma norepinephrine was increased (heart failure: 460 +/- 257 pg.ml-1, controls 182 +/- 49, P < 0.001). Myocardial cAMP levels are indistinguishable from controls in human heart failure and therefore do not contribute to a further characterization of the cardiac adrenergic system in these patients. This is most likely due to the impossibility of obtaining biopsies with truly unstimulated adenylyl cyclase activity.
Mucoadhesive Drug Delivery Systems (1997)

Mucoadhesion in drug delivery systems has recently gained interest among pharmaceutical scientists as a means of promoting dosage form residence time as well as improving intimacy of contact with various absorptive membranes of the biological system. Besides acting as platforms for sustained-release dosage forms, bioadhesive polymers can themselves exert some control over the rate and amount of drug release, and thus contribute to the therapeutic advantage of such systems. This paper describes some aspects of bioadhesion such as mucus layer, mucoadhesion, and theories of bioadhesion to explain the adhesion mechanism. The factors important to mucoadhesion, the methods used to study bioadhesion, and bioadhesive polymers are described. The methods that evaluate the mucoadhesive dosage forms and finally the bioadhesive drug delivery systems designed for several therapeutic purposes are presented.
Power Reduction on Embedded Systems Achieved by a Synchronous Finite State Machine Design Technique (2012)

Embedded applications that can be modeled as a Synchronous Finite State Machine are prone to a significant reduction in energy consumption when a very straightforward implementation approach is used. The potential for energy consumption reduction is highly dependent of the clock of the Synchronous Finite State Machine. Although the method is limited to synchronous FSM applications the benefits are worth the effort to attempt this modeling approach. The implementation requires only a timer (hardware timer or RTOS timer) that provides the clock of the Synchronous FSM. The energy reduction is obtained by changing the state of the processor to a low power state.
Pass-IoT: A platform for studying security, privacy and trust in IoT (2016)

Recent progress in the fields of networking, communications, computing, hardware and software have revolutionized the way people, smart objects and systems interact and exchange information. The Internet of Things (IoT) and Cyber-Physical Systems (CPS) will fuel the achievement of this new interconnected world. However, the success of these systems strongly depends on the security, privacy and trust of both IoT and CPS, as well as the sensitive data involved. Although these technologies offer many possibilities, the growing hardware and software complexity, as well as the existence of global access, increase the vulnerability to security attacks. This paper presents a testbed for implementing security, privacy and trust in IoT. Existing testbeds and algorithms are reviewed and the enhancements provided by our proposed platform are highlighted. The platform is based on an IoT gateway node that has 3 different hardware architectures (MCU, SDSoC, traditional CPU) integrated in the shape of a single testbed. One of the objectives is to test, optimize and, if doable, develop lightweight cryptographic algorithms to be deployed on the proposed testbed.
Stimulation of Human Peripheral Blood Lymphocytes by Periodate, Galactose Oxidase, Soybean Agglutinin, and Peanut Agglutinin: Differential Effects of Adherent Cells (1977)

Blastogenic responses of normal human peripheral lymphocytes to three distinct groups of mitogens were studied: Group I--phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM); Group II--soybean agglutinin (SBA) and peanut agglutinin (PNA); and Group III--galactose oxidase (GO) and sodium periodate (IO4-). SBA was mitogenic for human cells, and this effect was enhanced by treating the cells with neuraminidase (NA). PNA was mitogenic only after cells had been treated with NA. GO was effective before and activity was increased after lymphocytes were treated with NA. Responses to Group II and III mitogens were more variable than were those to Group I mitogens. Studies with purified T and B cells indicated that SBA and PNA were T cell mitogens, whereas IO4- and GO failed to stimulate either T or B cells. Adding macrophages back to this system indicated that they were both T cell mitogens with strict macrophage requirements. T cell responses to SBA and PNA were enhanced over responses to unfractionated cells to a degree that could not be explained simply by enrichment of the cultures with T cells. Removal of adherent cells from unfractionated cell suspensions again revealed a marked enhancement of responses to SBA and PNA, a consistent decrease in responses to IO4-, and a variable decrease in responses to GO. Similar results were found with 14C-leucine and 3H-uridine incorporation, as well as 3H-thymidine for the assessment of bastogenic response. Mechanisms responsible for these differential effects of macrophage depletion on lymphocyte responses to different groups of mitogens are yet to be determined. Either different mitogens require different lymphocyte to macrophage ratios for optimal stimulation, or some mitogens (i.e., SBA and PNA) form inhibitory complexees in the lymphocyte-macrophage mixture. In any case, variability in response to mitogenic agents in normal as well as pathologic states may be dependent on adherent cell populations, rather than on the lymphocytes themselves.
Effects of Temperature and Moisture on Dilute-Acid Steam Explosion Pretreatment of Corn Stover and Cellulase Enzyme Digestibility (2003)

Corn stover is emerging as a viable feedstock for producing bioethanol from renewable resources. Dilute-acid pretreatment of corn stover can solubilize a significant portion of the hemicellulosic component and enhance the enzymatic digestibility of the remaining cellulose for fermentation into ethanol. In this study, dilute H2SO4 pretreatment of corn stover was performed in a steam explosion reactor at 160°C, 180°C, and 190°C, approx 1 wt % H2SO4/ and 70-s to 840-s residence times. The combined severity (Log10 [R0] — pH), an expression relating pH, temperature, and residence time of pretreatment, ranged from 1.8 to 2.4. Soluble xylose yields varied from 63 to 77% of theoretical from pretreatments of corn stover at 160 and 180°C. However, yields >90% of theoretical were found with dilute-acid pretreatments at 190°C. A narrower range of higher combined severities was required for pretreatment to obtain high soluble xylose yields when the moisture content of the acid-impregnated feedstock was increased from 55 to 63 wt%. Simultaneous saccharification and fermentation (SSF) of washed solids from corn stover pretreated at 190°C, using an enzyme loading of 15 filter paper units (FPU)/ g of cellulose, gave ethanol yields in excess of 85%. Similar SSF ethanol yields were found using washed solid residues from 160 and 180°C pretreatments at similar combined severities but required a higher enzyme loading of approx 25 FPU/g of cellulose.
Negative Association Between Mediterranean Diet Adherence and COVID-19 Cases and Related Deaths in Spain and 23 OECD Countries: An Ecological Study (2021)

In December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) emerged in Wuhan, China, sparking the Coronavirus disease 2019 (COVID-19) pandemic. The high prevalence of nutrition-related COVID-19 risk factors including obesity, type 2 diabetes, and hypertension, suggests that healthy dietary approaches may mitigate COVID-19 related outcomes and possibly SARS-CoV-2 infection. Based on the fundamental role of nutrition in immune function and the well-documented association between Mediterranean diet consumption and risk reduction for chronic diseases that are comorbidities in COVID-19 patients, we hypothesized that there would be a relationship between Mediterranean diet adherence and COVID-19 cases and related deaths. In this perspective, we examined the association between regional adherence to a Mediterranean diet and COVID-19 cases and deaths using an ecological study design. We observed that Mediterranean diet adherence was negatively associated with both COVID-19 cases and related deaths across 17 regions in Spain and that the relationship remained when adjusted for factors of well-being. We also observed a negative association between Mediterranean diet adherence and COVID-19 related deaths across 23 countries when adjusted for factors of well-being and physical inactivity. The anti-inflammatory properties of the Mediterranean diet - likely due to the polyphenol content of the diet - may be a biological basis to explain our findings. However, there are confounding factors unrelated to dietary factors driving COVID-19 cases and related deaths across the regions in Spain and the 23 countries examined in our analysis. Our findings will need to be confirmed and further explored in cohort studies.
Scaleup in the Near-Well Region (2000)

Summary Scaleup techniques are commonly used to coarsen detailed geological models to scales more appropriate for reservoir simulation. These techniques typically generate upscaled permeabilities through solution of the local pressure equation, subject to some type of linear boundary condition. In the near-well region, coarse scale permeabilities computed in this manner may not adequately capture key features of the fine scale flow. In this article, we present a general method for computing accurate coarse scale wellblock transmissibilities and well indexes for vertical wells in two and three dimensions. The method is based on the solution of local well-driven flow problems subject to generic boundary conditions. Simulation results for two-dimensional systems indicate that the near-well treatment always provides improved predictions compared to those obtained using standard methods. In some parameter ranges, this improvement is quite substantial. Several three-dimensional models with vertical wells are also considered and improvement relative to the standard approach is achieved in all cases. Extension of the method to accommodate more general well configurations could result in significantly improved coarse scale simulations of nonconventional wells.
Diagnosis and management of human babesiosis (2015)

Babesiosis is a protozoan parasitic infection affecting humans and animals. These infections are commonly transmitted by various species of Ixodes ticks depending upon the geographical location. They can also be transmitted by packed cell transfusion and transplacental route from mother to child. Various species have been reported to cause human infections, of which Babesia microti is the most common species reported globally. Usually, Babesia infections are asymptomatic or mild, but can be severe/life-threatening in immunosuppressed or splenectomized individuals. A high index of clinical suspicion in residents of endemic areas or individuals who had a recent travel history to such areas, with laboratory confirmation can guide an early institution of appropriate antimicrobial therapy, thereby preventing complications and death.
Algorithm 500: Minimization of Unconstrained Multivariate Functions [E4] (1976)

This subroutine finds a local minimum of a nonlinear function of n variables f(x) where x = (xl, x~,..., xn), n > 1, can be any real numbers.
Comparison of various treatments for sleep bruxism using determinants of number needed to treat and effect size. (2007)

Although the NNT and ES results seem to indicate that the MAD and clonidine are the most promising experimental treatments, both treatments were associated with side effects (ie, discomfort for the MAD; REM suppression and morning hypotension for clonidine). The occlusal splint and clonazepam seem to be acceptable short-term alternatives, although further longitudinal, large sample size randomized controlled trials in SB management are needed.
Hierarchical Patterns of Transgene Expression Indicate Involvement of Developmental Mechanisms in the Regulation of the Maize <i>P1-rr</i> Promoter (2000)

The maize P1-rr gene encodes a Myb-homologous transcription factor that regulates the synthesis of red flavonoid pigments. Maize plants transformed with segments of the P1-rr promoter driving a GUS reporter gene exhibit significant variation in transgene expression, both between independent transformation events and among sibling plants derived from a single event. Interestingly, variability in spatial expression is not random; rather, transgene activity occurs predominantly in five patterns that fit a hierarchy: expression is most common in kernel pericarp, with sequential addition of expression in cob glumes, husk, silk, and tassel. The hierarchical expression pattern of P-rr::GUS transgenes suggests a possible model for developmental regulation of the P1-rr gene. Our results demonstrate that variability in transgene expression, a common occurrence in transgenic plant studies, can be informative if adequately analyzed to uncover underlying patterns of gene expression.