gebhart/patrepeval huggingface dataset:
Effects of Filler-Binders and Lubricants on Physicochemical Properties of Tablets Obtained by Direct Compression: A 2 2 Factorial Design (2008)

SUMMARY. The influence of the filler-binder granulometry (Avicel PH 101 or Avicel PH 102) and the type of lubricants (magnesium stearate or stearic acid) by means of a 22 factorial design on the physicochemical characteristics of tablets containing high amount of an active substance have been studied. Acetylsalicylic acid (ASA) was used as a model drug. All formulations met pharmacopeial specifications for mean weight, assay, uniformity of content, and disintegration time. Higher hardness and higher percentage of drug dissolved (p ≤ 0.05) was shown by formulations prepared with stearic acid compared to formulations prepared with magnesium stearate. Tablet friability was significantly higher (p ≤ 0.05) for formulations prepared with Avicel PH 101 in relation to formulations containing Avicel PH 102. The type of lubricant as well as the filler granulometry showed to have a great influence on the physicochemical and biopharmaceutical characteristics of tablets containing high amount of active substance obtained by direct compression. RESUMEN. “Efecto de los Excipientes Diluyente-aglutinante y Lubricante sobre las Propiedades Fisicoquimicas de Tabletas Obtenidas por Compresion Directa: un Diseno Factorial 22”. En el presente trabajo se estudio la influencia de la granulometria del diluyente-aglutinante (Avicel PH 101 o Avicel PH 102) y el tipo de lubricante (estearato de magnesio o acido estearico), mediante un diseno factorial 22, sobre las caracteristicas fisicoquimicas de tabletas con un alto contenido de principio activo. El acido acetilsalicilico (ASA) fue utilizado como farmaco modelo. Todas las formulaciones cumplian con las especificaciones de farmacopea en cuanto al peso promedio, ensayos de uniformidad de contenido y tiempo de desintegracion. Mayor dureza y porcentaje disuelto (p ≤ 0,05) fueron observados en las formulaciones preparadas con acido estearico comparadas con aquellas en que se utilizo estearato de magnesio. La friabilidad de las tabletas fue significativamente mayor (p ≤ 0,05) para aquellas preparadas con Avicel PH 101 en comparacion con las que contenian Avicel PH 102. Tanto el tipo de lubricante como la granulometria del diluyente mostraron una gran influencia en las caracteristicas fisicoquimicas y propiedades biofarmaceuticas de las tabletas obtenidas por compresion directa con un alto contenido de sustancia activa.
Semantic indexing and computational aesthetics (2013)

Semantic Indexing and Computational Aesthetics are two closely related fields. For some aspects they are similar, complementary for others, and sometimes completely disjoint. Semantic Indexing is about automatically identifying content in natural images, namely recognizing objects and scenes. Computational Aesthetics provides a set of techniques to automatically assign a beauty degree to a given image. In our work, we enrich both types of visual analysis by exploring the synergy of those two fields. We investigate the role of Semantic Indexing techniques for Computational Aesthetics Frameworks, and, vice versa, the importance of Aesthetic features for Semantic Indexing prediction. We show the benefits and the limits of this synergy, and propose some improvements in this direction.
Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease (2011)

Rapamycin is a macrolide immunosuppressant drug, originally used as an anti-fungal agent, which is widely used in transplantation medicine to prevent organ rejection. Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine kinase with pleiotropic cellular functions, regulating processes such as growth and metabolism, cell survival, transcription and autophagy. TOR intervenes in two distinct enzymatic complexes with different functions, a rapamycin-sensitive complex TORC1 and a rapamycin-insensitive complex TORC2. Rapamycin has an inhibitory effect on TORC1 activity and it has been suggested to increase life span, an effect correlated with decreased protein biosynthesis and autophagy activation. In the CNS, rapamycin shows beneficial effects in neuronal survival and plasticity, thus contributing to memory improvement. In this review, evidence implying rapamycin and TOR in aging/life span extension and memory improvement will be discussed. Recent findings about the effects of rapamycin on Alzheimer's disease-associated neuropathology will be also discussed.
Incremental analysis of real programming languages (1997)

A major research goal for compilers and environments is the automatic derivation of tools from formal specifications. However, the formal model of the language is often inadequate; in particular, LR( k ) grammars are unable to describe the natural syntax of many languages, such as C ++ and Fortran, which are inherently non-deterministic. Designers of batch compilers work around such limitations by combining generated components with ad hoc techniques (for instance, performing partial type and scope analysis in tandem with parsing). Unfortunately, the complexity of incremental systems precludes the use of batch solutions. The inability to generate incremental tools for important languages inhibits the widespread use of language-rich interactive environments.We address this problem by extending the language model itself, introducing a program representation based on parse dags that is suitable for both batch and incremental analysis. Ambiguities unresolved by one stage are retained in this representation until further stages can complete the analysis, even if the reaolution depends on further actions by the user. Representing ambiguity explicitly increases the number and variety of languages that can be analyzed incrementally using existing methods.To create this representation, we have developed an efficient incremental parser for general context-free grammars. Our algorithm combines Tomita's generalized LR parser with reuse of entire subtrees via state-matching. Disambiguation can occur statically, during or after parsing, or during semantic analysis (using existing incremental techniques); program errors that preclude disambiguation retsin multiple interpretations indefinitely. Our representation and analyses gain efficiency by exploiting the local nature of ambiguities: for the S PEC 95 C programs, the explicit representation of ambiguity requires only 0.5% additional space and less than 1% additional time during reconstruction.
Importance Sampling of Many Lights on the GPU (2019)

The introduction of standardized APIs for ray tracing, together with hardware acceleration, opens up possibilities for physically based lighting in real-time rendering. Light importance sampling is one of the fundamental operations in light transport simulations, applicable to both direct and indirect illumination. This chapter describes a bounding volume hierarchy data structure and associated sampling methods to accelerate importance sampling of local light sources. The work is based on recently published methods for light sampling in production rendering, but it is evaluated in a real-time implementation using Microsoft DirectX Raytracing.
A turbo iteration algorithm in 16QAM hierarchical modulation (2010)

In the next generation communication protocol “DVB-SH”, it offers a new transmitting scheme based on the turbo code, OFDM modulation and 16QAM hierarchical modulation to increase the flexibility in the information delivery. This scheme is using Hierarchical modulation to enhance the UE (user equipment) performance which is in the center of a sector and also ensure the basic service when UE move to the region of a sector. Hierarchical modulation uses two different bit streams on to different constellation of the constellation map. This scheme ensures two different bit streams have corresponding BER performance and then bring on the flexibility to the transmitting service. The simulation results indicates that in the Rayleigh and Gaussian channel, this scheme can gain a very high BER performance of high priority bit stream, and in the high SNR, it can also gain a high BER performance of low priority bit stream.
NDE of spacecraft materials using 3D Compton backscatter x-ray imaging (2016)

We present the results of testing of the NDE performance of a Compton Imaging Tomography (CIT) system for single-sided, penetrating 3D inspection. The system was recently developed by Physical Optics Corporation (POC) and delivered to NASA for testing and evaluation. The CIT technology is based on 3D structure mapping by collecting the information on density profiles in multiple object cross sections through hard x-ray Compton backscatter imaging. The individual cross sections are processed and fused together in software, generating a 3D map of the density profile of the object which can then be analyzed slice-by-slice in x, y, or z directions. The developed CIT scanner is based on a 200-kV x-ray source, flat-panel x-ray detector (FPD), and apodized x-ray imaging optics. The CIT technology is particularly well suited to the NDE of lightweight aerospace materials, such as the thermal protection system (TPS) ceramic and composite materials, micrometeoroid and orbital debris (MMOD) shielding, spacecraft pressure walls, inflatable habitat structures, composite overwrapped pressure vessels (COPVs), and aluminum honeycomb materials. The current system provides 3D localization of defects and features with field of view 20x12x8 cm3 and spatial resolution ∼2 mm. In this paper, we review several aerospace NDE applications of the CIT technology, with particular emphasis on TPS. Based on the analysis of the testing results, we provide recommendations for continued development on TPS applications that can benefit the most from the unique capabilities of this new NDE technology.
Nonlinear least-squares fitting of multivariate absorption data (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonlinear least-squares fitting of multivariate absorption dataMarcel. Maeder and Andreas D. ZuberbuehlerCite this: Anal. Chem. 1990, 62, 20, 2220–2224Publication Date (Print):October 15, 1990Publication History Published online1 May 2002Published inissue 15 October 1990https://doi.org/10.1021/ac00219a013RIGHTS & PERMISSIONSArticle Views1128Altmetric-Citations373LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (625 KB) Get e-Alerts Get e-Alerts
Time course studies on the effectiveness of tetrodotoxin in reducing consequences of spinal cord contusion (2001)

Focal injection of the sodium channel blocker tetrodotoxin (TTX) into the injury site at either 5 or 15 min after a standardized thoracic contusion spinal cord injury (SCI) reduces white matter pathology and loss of axons in the first 24 hr after injury. Focal injection of TTX at 15 min after SCI also reduces chronic white matter loss and hindlimb functional deficits. We have now tested the hypothesis that the reduction in chronic deficits with TTX treatment is associated with long-term preservation of axons after SCI and compared both acute (24 hr) and chronic (6 weeks) effects of TTX administered at 15 min prior to and 5 min or 4 hr after SCI. Our results indicate a significant reduction of acute white matter pathology in rats treated with TTX at 15 min before and 5 min after injury but no effect when treatment was delayed until 4 hr after contusion. Compared with injury controls, groups treated with TTX at 5 min and 4 hr after injury did not show a significant deficit reduction, nor was there a significant sparing of white matter at 6 weeks compared with injury controls. In contrast, the group treated with TTX at 15 min before SCI demonstrated significantly reduced hindlimb functional deficits beginning at 1 week after injury and throughout the 6 weeks of the study. This was associated with a significantly higher axon density in the ventromedial white matter at 6 weeks. The results demonstrate that blockade of sodium channels preserves axons from loss after SCI and points to the importance of time of administration of such drugs for therapeutic effectiveness.
SYNTHESIS OF NEW NICOTINOYL AMINO ACID DERIVATIVES (1994)

(S)-and/or (R)-(2-methyl-3-benzyloxycarbonyl-5-oxo-4-0xazolidinyl)-acetyl chloride, prepared from S-aspartic acid, which was reacted with 3-trimethyl stannylpyridine to give the corresponding pyridyl-ketone, then converted into enantiomeric (S)-and (R)-a- methylnicotinylalanine by hydrolysis with hydrochloric acid. Analogously, a-nicotinylalanine III was prepared from L-glutamic acid.
ChemInform Abstract: A New CBrF3 Process for Etching Tapered Trenches in Silicon (1987)

Abstract has been developed for the generation of trench capacitors in highly integrated DRAM's. Trenches, 1 μm wide and up to 2 μm deep, are etched in reactive ion etching mode with CBrF 3 using a single wafer etcher.
Structural and biological features of a novel plant defensin from Brugmansia x candida (2018)

Data from both the laboratory and clinic in the last decade indicate that antimicrobial peptides (AMPs) are widely regarded as potential sources of future antibiotics owing to their broad-spectrum activities, rapid killing, potentially low-resistance rate and multidirectional mechanisms of action compared to conventional antibiotics. Defensins, a prominent family of AMPs, have been found in a wide range of organisms including plants. Thailand is a rich source of plants including medicinal plants used therapeutically, however there is no report of defensin from among these plants. In this study, a novel plant defensin gene, BcDef, was successfully cloned from Brugmansia x candida (Bc). BcDef cDNA was 237 bp in length, encoding 78 amino acids with a putative 31-amino acid residue signal peptide at the N-terminal followed by the mature sequence. BcDef shared high sequence identity (78-85%) with Solanaceae defensins and belonged to the class I plant defensins. From homology modeling, BcDef shared a conserved triple stranded β-sheet (β1-β3) and one α-helix (α1) connected by a loop (L1-L3). BcDef1 peptide, designed from the γ-core motifs of BcDef located in loop 3, showed antibacterial activity against both Gram-positive and Gram-negative pathogens with the lowest MIC (15.70 μM) against Staphylococcus epidermidis. This peptide affected cell membrane potential and permeability, and caused cell membrane disruption. Moreover, BcDef1 also exhibited antioxidant activity and showed low cytotoxicity against mouse fibroblast L929 cells. These findings may provide an opportunity for developing a promising antibacterial agent for medical application in the future.
Laser trimming of thyristors to add an overvoltage self-protected turn-on feature (1985)

Laser processing techniques have produced thyristors which are free from destructive overvoltage breakdown. Laser-fabricated structures that generate self-triggering currents are described. Test results demonstrate a temperature-stable switching voltage, uncompromised di/dt ratings, and the ability to withstand 14,000,000 successive overvoltage transients. Circuit implications of overvoltage self-protected thyristors are discussed.
An adaptive optics biomicroscope for mouse retinal imaging (2007)

In studying retinal disease on a microscopic level, in vivo imaging has allowed researchers to track disease progression in a single animal over time without sacrificing large numbers of animals for statistical studies. Historically, a drawback of in vivo retinal imaging, when compared to ex vivo imaging, is decreased image resolution due to aberrations present in the mouse eye. Adaptive optics has successfully corrected phase aberrations introduced the eye in ophthalmic imaging in humans. We are using adaptive optics to correct for aberrations introduced by the mouse eye in hopes of achieving cellular resolution retinal images of mice in vivo. In addition to using a wavefront sensor to drive the adaptive optic element, we explore the using image data to correct for wavefront aberrations introduced by the mouse eye. Image data, in the form of the confocal detection pinhole intensity are used as the feedback mechanism to control the MEMS deformable mirror in the adaptive optics system. Correction for wavefront sensing and sensor-less adaptive optics systems are presented.
Measurement and Analysis of Spyware in a University Environment. (2004)

Abstract Over the past few years, a relatively new computingphenomenon has gained momentum: the spread of &amp;quot;spyware. &amp;quot; Though most people are aware of spyware, theresearch community has spent little effort to understand its nature, how widespread it is, and the risks it presents.This paper is a first attempt to do so. We first discuss background material on spyware, in-cluding the various types of spyware programs, their methods of transmission, and their run-time behavior.By examining four widespread programs (Gator, Cydoor, SaveNow, and eZula), we present a detailed analysis oftheir behavior, from which we derive signatures that can be used to detect their presence on remote computersthrough passive network monitoring. Using these signatures, we quantify the spread of these programs amonghosts within the University of Washington by analyzing a week-long trace of network activity. This trace was gath-ered from August 26th to September 1st, 2003. From this trace, we show that: (1) these four pro-grams affect approximately 5.1 % of active hosts on campus, (2) many computers that contain spyware have morethan one spyware program running on them concurrently, and (3) 69 % of organizations within the universitycontain at least one host running spyware. We conclude by discussing security implications of spyware and spe-cific vulnerabilities we found within versions of two of these spyware programs. 1
Deposition of ordered phthalocyanine films by spin coating (1992)

Thin films of octaalkyl-substituted phthalocyanines were prepared by spin coating. The films were remarkably smooth and showed optical absorption spectra with Davydov splitting, characteristic of crystalline order, similar to those of structurally related compounds prepared by the Langmuir–Blodgett technique. The crystallinity was confirmed by X-ray diffraction. The technique may have advantages for device fabrication.
Realization of broadband data services in ATM-networks (2002)

It is pointed out that broadband data services are expected to play an important role in the future B-ISDN (broadband integrated services digital network) which will be based on the ATM (asynchronous transfer mode) transmission technique. The authors first describe some significant broadband data applications. They then focus on the realization of broadband LAN (local area network) interconnection in the B-ISDN. They discuss two possible configurations and show that efficient interconnection of LANs across the B-ISDN can be provided using semipermanent virtual ATM-connections and connectionless servers attached to the ATM-switching nodes. The proposed solution provides a connectionless service on top of ATM. It avoids both the complexity and the inefficiency of a full mesh of semipermanent connections and the difficulties associated with the use of dialed-up connections regarding high call processing load and traffic issues. The solution is most suitable for connections of less than 10 Mbit/s. The efficiency can be increased by concentrating and smoothing data traffic at points in the network where it is not mixed with other traffic sensitive to delay jitter. Various possibilities for locating the concentrators or smoothing buffers are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Possible Psychological Effects of Ultrasound Scanning on Women (2014)

Questionnaires were designed and given to 30 female subjects to investigate the possible psychological effects caused by the use of ultrasound scanning. The answers were analyzed in a numerical way and correlation tests were run to explore the relations among various factors. No significant correlation was found between any pair of the four selected factors. Further interviews with the subjects and detailed qualitative study of the answers provided answers for the results, and suggested that the possible psychological effects introduced by the ultrasound scanning, if any, were very limited.
Double-phase 99mTc-sestamibi scintimammography and trans-scan in diagnosing breast cancer. (1999)

Double-phase SMM was sensitive and specific in detecting breast cancer. This method may reduce the rate of negative breast biopsies in tumors >1 cm. T-scan was only moderately accurate in detecting breast cancer. Its addition to SMM did not improve significantly the rate of breast cancer detection. However, because of its complete noninvasiveness, large-scale applicability and low cost, T-scan deserves further refining.
Ultra Low Power Magnetic Flip-Flop Based on Checkpointing/Power Gating and Self-Enable Mechanisms (2014)

Advanced computing systems suffer from high static power due to the rapidly rising leakage currents in deep sub-micron MOS technologies. Fast access non-volatile memories (NVM) are under intense investigation to be integrated in Flip-Flops or computing memories to allow system power-off in standby state and save power. Spin Transfer Torque MRAM (STT-MRAM) is considered the most promising NVM to address this issue thanks to its high speed, low power, and infinite endurance. However, one of the disadvantages of STT-MRAM for the computing purpose is its relatively high write energy to build up Magnetic Flip-Flop (MFF). In this paper, we propose a power-efficient MFF design architecture to address this challenge based on the combination of checkpointing operation, power gating and self-enable mechanisms. Multi non-volatile storages can be integrated locally in a conventional FF without significant area overhead benefiting from the 3-D implementation of STT-MRAM. We performed electrical simulations (i.e. transient and statistical) to validate its functional behaviors and evaluate its performance by using an accurate spice model of STT-MRAM and an industrial 40 nm CMOS design kit. The simulation results confirm its lower power consumption compared to conventional CMOS FF and the other structures.