gebhart/patrepeval huggingface dataset:
Practical elimination of near-duplicates from web video search (2007)

Current web video search results rely exclusively on text keywords or user-supplied tags. A search on typical popular video often returns many duplicate and near-duplicate videos in the top results. This paper outlines ways to cluster and filter out the near-duplicate video using a hierarchical approach. Initial triage is performed using fast signatures derived from color histograms. Only when a video cannot be clearly classified as novel or near-duplicate using global signatures, we apply a more expensive local feature based near-duplicate detection which provides very accurate duplicate analysis through more costly computation. The results of 24 queries in a data set of 12,790 videos retrieved from Google, Yahoo! and YouTube show that this hierarchical approach can dramatically reduce redundant video displayed to the user in the top result set, at relatively small computational cost.
A Machine Learning Perspective on Predictive Coding with PAQ8 (2012)

PAQ8 makes use of several simple machine learning models and algorithms. We show how understanding PAQ8 enables us to improve the algorithms. We also present a broad range of new applications of PAQ8 to machine learning tasks including language modeling and adaptive text prediction, adaptive game playing, classification, and lossy compression using features acquired via unsupervised learning.
Hypoxia-Inducible Factor-2α Regulates GM-CSF–Derived Soluble Vascular Endothelial Growth Factor Receptor 1 Production from Macrophages and Inhibits Tumor Growth and Angiogenesis (2011)

Macrophage secretion of vascular endothelial growth factor (VEGF) in response to the hypoxic tumor microenvironment contributes to tumor growth, angiogenesis, and metastasis. We have recently demonstrated that macrophages stimulated with GM-CSF at low O(2) secrete high levels of a soluble form of the VEGF receptor 1 (sVEGFR-1), which neutralizes VEGF and inhibits its biological activity. Using small interfering RNA targeting to deplete hypoxia-inducible factor (HIF)-1α or HIF-2α in murine macrophages, we found that macrophage production of sVEGFR-1 in response to low O(2) was dependent on HIF-2α, whereas HIF-1α specifically regulated VEGF production. In our current report, we evaluated the growth of B16F10 malignant melanoma in mice with a monocyte/macrophage-selective deletion of HIF-1α or HIF-2α (HIF-1α(flox/flox)- or HIF-2α(flox/+)/LysMcre mice). GM-CSF treatment increased intratumoral VEGF and sVEGFR-1 in control mice, an effect that was associated with a decrease in microvessel density. GM-CSF treatment of HIF-1α(flox/flox)/LysMcre mice induced sVEGFR-1 but not VEGF, resulting in an overall greater reduction in tumor growth and angiogenesis compared with control mice. In addition, real-time PCR for melanoma-specific genes revealed a significantly reduced presence of lung micrometastases in HIF-1α(flox/flox)/LysMcre mice treated with GM-CSF. Conversely, GM-CSF treatment induced VEGF but not sVEGFR-1 in HIF-2α(flox/+)/LysMcre mice, and, correspondingly, GM-CSF did not decrease tumor growth, angiogenesis, or lung metastasis in these mice. This study reveals opposing roles for the HIFs in the regulation of angiogenesis by tumor-associated macrophages and suggests that administration of GM-CSF might be an effective means of inducing sVEGFR-1 and inhibiting tumor growth and angiogenesis in patients with melanoma.
Inhibition of Cell Adhesion by a Cadherin-11 Antibody Thwarts Bone Metastasis (2013)

Monotherapy using a cadherin-11 antibody is a suitable option for the prevention of bone metastases.
VALVE: variable length value encoder for off-chip data buses (2006)

We propose variable length value encoding (VALVE) technique to reduce the power consumption in the off-chip data buses. While past research has focused on encoding fixed length data values to reduce the transition activity in the data buses, our proposed scheme is capable of detecting and encoding variable length bit patterns in the data values. VALVE also does not require prior knowledge of input data and uses just one external control signal. We evaluate our proposed scheme using a large spectrum of benchmarks and we achieve an energy reduction of 58% on an average and up to 75% on some benchmarks. We also analyze the performance penalty incurred due to the codec delay, which is found to be 0.45% of the total program execution time. We find that VALVE requires a minimal area of 0.0486 mm/sup 2/, which can be easily implemented with in a memory controller.
A preferred trajectory tracking steering law for spacecraft with redundant CMGs (2005)

Spacecraft which use control moment gyroscopes (CMGs) as momentum exchange devices in an attitude control system suffer from CMG configurations which preclude arbitrary torque generation. The exploitation of CMG null-space motion which exists in redundant systems allows the development of CMG steering laws which attempt to avoid these singular configurations. This paper presents a new singularity avoidance CMG steering law which operates by converging to a set of "preferred" trajectories in which no singular points exist. The underlying principle of CMG preferred trajectories as well as proof of the stability of the convergence process to these trajectories is presented. Simulation results demonstrating the convergence process as well as the resulting singularity avoidance properties are presented as well.
A high Q piezoelectric resonator as a portable VLF transmitter (2019)

Very low frequency communication systems (3 kHz-30 kHz) enable applications not feasible at higher frequencies. However, the highest radiation efficiency antennas require size at the scale of the wavelength (here, >1 km), making portable transmitters extremely challenging. Facilitating transmitters at the 10 cm scale, we demonstrate an ultra-low loss lithium niobate piezoelectric electric dipole driven at acoustic resonance that radiates with greater than 300x higher efficiency compared to the previous state of the art at a comparable electrical size. A piezoelectric radiating element eliminates the need for large impedance matching networks as it self-resonates at the acoustic wavelength. Temporal modulation of this resonance demonstrates a device bandwidth greater than 83x beyond the conventional Bode-Fano limit, thus increasing the transmitter bitrate while still minimizing losses. These results will open new applications for portable, electrically small antennas.
Increasing emotional intelligence through training : current status and future directions (2013)

Emotional intelligence consists of adaptive emotional functioning involving inter-related\ncompetencies relating to perception, understanding, utilising and managing emotions in\nthe self and others. Researchers in diverse fields have studied emotional intelligence and found the construct to be associated with a variety of intrapersonal and interpersonal\nfactors such as mental health, relationship satisfaction, and work performance. This\narticle reviews research investigating the impact of training in emotional-intelligence\nskills. The results indicate that it is possible to increase emotional intelligence and that\nsuch training has the potential to lead to other positive outcomes. The paper offers\nsuggestions about how future research, from diverse disciplines, can uncover what types\nof training most effectively increase emotional intelligence and produce related\nbeneficial outcomes.
Friedreich ataxia in carriers of unstable borderline GAA triplet‐repeat alleles (2004)

Friedreich ataxia patients are homozygous for expanded GAA triplet-repeats containing 66 to 1,700 triplets. We report two patients with delayed-onset, hyperreflexia and gradually progressive disease. Both were heterozygous for large expansions and also carried alleles with 44 and 66 triplet-repeats, respectively. Due to somatic instability, 15% (GAA-44) and 75% (GAA-66) of cells contained alleles with >/=66 triplet-repeats, constituting a plausible mechanism for their mild phenotype. A sibling with a stable GAA-37 allele and a large expansion was clinically normal. Instability of borderline alleles confers a risk for Friedreich ataxia, and the range of pathogenic alleles is broader than previously recognized.
USE OF (CA)n POLYMORPHISMS TO DETERMINE THE ORIGIN OF BLOOD CELLS AFTER ALLOGENEIC CANINE MARROW GRAFTING (1994)

We have used a polymerase chain reaction-based assay measuring polymorphic (CA)n repeats, a class of simple sequence repeats, to assess the success of allogeneic canine marrow transplants. Results were compared with those obtained with karyotype analysis of dividing cells in recipients that were sex mismatched with their marrow donors. Twenty recipients were conditioned for transplantation of genotypically DLA-identical littermate marrow by 450 cGy of total-body irradiation. In 2 recipients, results could not be compared, since either only cytogenetic or dinucleotide (CA)n marker data existed. Both dogs had autologous marrow recovery. In 15 of the remaining 18 recipients, complete agreement was found between the results obtained with dinucleotide (CA)n markers, cytogenetic studies, and granulocyte changes after transplantation. Seven of the 15 showed eventual autologous recovery, 6 displayed mixtures of host and donor cells, and 2 showed donor-type hematopoiesis. Two of the 18 dogs showed mixed chimerism with (CA)n markers and autologous recovery by cytogenetics, findings that may be related to differences in cells analyzed by the two techniques–i.e., all nucleated cells by (CA)n markers versus dividing cells by cytogenetics. In one additional recipient, results of marrow cytogenetics, granulocyte changes, and (CA)n markers were consistent with a successful allograft, while peripheral blood cytogenetics suggested autologous recovery, possibly the result of erroneous blood sampling. Polymerase chain reaction-based testing for dinucleotide repeat (CA)n polymorphisms, originally developed for genetic mapping in the dog, is useful and reliable when compared with cytogenetic studies, in assessing the success of allogeneic marrow transplants in dogs.
Pd-Catalyzed Efficient One-Pot Sequential Cross-Coupling Reactions of Aryl Dihalides (2008)

The palladium complex containing N-heterocyclic carbene ligands catalyzes one-pot sequential Heck/Suzuki, Heck/Heck, and Heck/Sonogashira coupling reactions of aryl dihalides to afford unsymmetrically substituted arenes in excellent yields.
Highly Stable and Rapid Switching Electrochromic Thin Films Based on Metal–Organic Frameworks with Redox-Active Triphenylamine Ligands (2020)

Metal-organic frameworks (MOFs), known for their tailorable porous structures and large specific surface areas, are appealing for electrochromic applications as their abundant pores may greatly benefit the charge transport required for electrochromic switching. Herein, for the first time, a simple, scalable, and cost-effective electrochemical deposition method for fabrication of high-performance and durable MOFs-based electrochromic films with redox-active ligands was developed. The fabricated film can achieve rapid switching speed (both coloration and bleaching time <5 s) because the inherent cavities of the MOFs greatly facilitate ion insertion and extraction. In addition, the film constructed with optimized parameters shows a high optical contrast of 65%@700 nm and can be stably switched for 1000 cycles with <5% contrast attenuation, which is by far the best cycling performance for MOFs-based electrochromic materials ever reported. Furthermore, our method enables the scalable preparation of large-area MOFs-based electrochromic thin films without using large high-pressure reaction vessels, and the as-prepared film in this work could be switched well between colored and bleached states. This new method, therefore, opens up a new avenue to broaden the use of MOFs-based thin films for electrochromic applications.
Sustained Release of Phenytoin Following the Oral Administration of Phenytoin Sodium/Ethylcellulose Microcapsules in Human Subjects and Rabbits. (1994)

Phenytoin sodium was microencapsulated with ethylcellulose (EC) by a coacervation-phase separation method from ethyl acetate solution to develop a prolonged release dosage form of phenytoin. Release of phenytoin from the microcapsules (phenytoin sodium/EC) was evaluated by the JP dissolution test in JP disintegration media No. 1 and No. 2. The release rates of phenytoin from phenytoin sodium powders were extremely rapid in both media, however, the release rates from the microcapsules were much more retarded. Following the oral administration of microcapsules to rabbits, prolonged plasma concentrations of phenytoin were obtained, while microcapsules orally administered to human subjects showed prolonged urinary excretion of phenytoin metabolites.
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward (2018)

Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds variably to a range of pharmacological interventions, and little consensus exists regarding specific methodologies for its execution. Regardless, the test is widely applied to investigate the effects of pharmacological, genetic, and behavioral manipulations on purported behaviors related to the said neuropsychiatric constructs. Therefore, in the present review we attempt to expound the collective translational significance of the MBT. We do this by (1) reviewing burying behavior as a natural behavioral phenotype, (2) highlighting key aspects of anxiety and obsessive-compulsive disorder from a translational perspective, (3) reviewing the history and proof of concept of the MBT, (4) critically appraising potential methodological confounds in execution of the MBT, and (5) dissecting responses of the MBT to various pharmacological interventions. We conclude by underlining that the collective translational value of the MBT will be strengthened by contextually valid experimental designs and objective reporting of data.
Specification level interoperability (1990)

Whereas most previous approaches to interoperability have provided support at the representation level, the authors are pursuing an approach that provides support at the specification level. They have developed a model of such support that consists of four components: (1) a unified type model, which is a notation for describing the entities to be shared by interoperating programs; (2) language bindings, which connect the type models of the languages to the unified type model; (3) underlying implementations, which realize the types used by the different interoperating programs; and (4) automated assistance, which eases the task of combining components into an interoperable whole. The authors discuss the representation-level and specification-level approaches to interoperability, describe their current prototype realization of the specification-level approach and their experience with its use, and outline their plans for extending both the approach and its realization. Experiences with the initial prototype are found to be extremely encouraging. >
Antidiuretic effect of antimuscarinic agents in rat model depends on <scp>C</scp> ‐fibre afferent nerves in the bladder (2013)

These results suggest that antimuscarinic agents decrease urine volume through C-fibres in the bladder; thus, antimuscarinics with inhibitory effects on C-fibres could be beneficial for nocturia with nocturnal polyuria.
Melatonin receptors in rat hippocampus: molecular and functional investigations (2002)

Since binding sites for melatonin have been found in the hippocampus of several mammals, it has been suggested that the pineal hormone melatonin is able to modulate neuronal functions of hippocampal cells. In order to get more insight into the role of melatonin for the functions of hippocampal cells, the following experiments were performed: male rats, maintained under a 12/12-h light-dark cycle, were sacrificed by decapitation at zeitgeber times (h) ZT2, ZT8, and ZT15 (ZT0 = lights on); for experiment 1, gene expression for melatonin receptors was detected in the hippocampus and in hippocampal subfields by means of the RT-PCR technique; for experiment 2, electrophysiological and pharmacological properties of melatonin receptors heterologously expressed in Xenopus oocytes after injection of mRNA from the hippocampus were analyzed by means of voltage clamp technique; and for experiment 3, effects of melatonin on the spontaneous firing rate of action potentials in the CA1 regions of hippocampal slices were analyzed by means of extracellular recordings. The RT-PCR data revealed that transcripts for both the MT1 and MT2 melatonin receptors are present in the dentate gyrus, CA3, and CA1 regions, and the subiculum of the hippocampus. Injection of mRNA from rat hippocampus into the Xenopus oocytes led to the functional reconstitution of melatonin-sensitive receptors, which activates calcium-dependent chloride inward currents. The melatonin responses were abolished by simultaneous administration of the antagonists 2-phenylmelatonin and luzindole, and were unaffected by the MT2 antagonist 4-phenyl-2-propionamidotetralin. Bath-applied melatonin (1 micromol/l) enhances the firing rate of neurons in the CA1 region. The effect was small in experiments performed at ZT8 (<2 times the initial level) and large in experiments performed at ZT15 (>6 times). The changes of neuronal firing rate induced by melatonin were completely suppressed with simultaneous administration of the melatonin receptor antagonist luzindole (10 micromol/l). The results indicate that melatonin may play an important role in modulating neuronal excitability in the hippocampus.
Data compression for storage of resting ECGs digitized at 500 samples/second. (1992)

Data compression of resting electrocardiograms (ECGs) digitized at 500 samples per second (sps) is presented. Tradeoffs between the fidelity of reconstructed data and the overall compression are examined. Data of the median (average) complexes are retained at 500 sps and full resolution and encoded only to reduce redundancy. The raw data for rhythm analysis are evaluated for lowpass filtering and down-sampling (decimation) and requantization. After subtracting the medians from the raw data, the resulting residue signal is examined in detail for data reduction and encoding. Various options for compression of the residue signal are presented. Specific issues examined are the acceptable decimation and requantization of the residue signal. Another important aspect evaluated is the bimodal decimation of the QRS and the rest of the cardiac complex. Here, the QRS complexes are kept at 500 sps and the rest of the data decimated to lower sampling rates. This novel approach reduces data distortion while achieving significant compression. Details of the compression scheme and its evaluation on uncompressed 500-sps ECGs from the European Common Standards for Electrocardiography (CSE) database (128 ECGs with normal sinus rhythm, atrioventricular blocks, atrial fibrillation and flutter, ventricular arrhythmias, and excessive noise) are elucidated. Performance indexes [root mean square (RMS) error, percent RMS difference, normalized RMS difference, maximum peak error, and compression ratio] are computed. To validate the compression method, qualitative evaluation was performed by two physicians overreading the ECGs by comparing the reconstructed waveforms with the original uncompressed data. The median data are retained at 500 sps and full precision. For rhythm data, the bimodal decimation of the residue signal to 125 sps at 10 microvolts resolution preserved the fidelity of the ECG signals well, while giving good data compression. Abnormal atrial activity was well preserved and the QRS was retained without distortion. The average size of a 10-sec compressed ECG with the medians is around 4.5 kilobytes.
Review of Finite Element Procedures for Earth Retaining Structures (1990)

This miscellaneous paper presents a review of previous work in which the finite element method was used to analyze the soil structure interaction of earth retaining structures such as U-frame locks, gravity walls, and basement walls. This method of analysis results in the computation of stresses and displacement for both the structure and the soil backfill. Applications of the procedure have shown the importance of modeling the actual construction process as closely as possible and the use of a nonlinear stress-strain soil model. Additional requirements include modeling the interface between the soil backfills and the wall using interface elements. This paper also includes two recent applications of the finite element method for the analysis of earth retaining structures which are loaded so heavily that a gap develops along the interface between the base of the structure and its foundation. The results are compared to those computed using the conventional force equilibrium method of analysis.
CO<sub>2</sub> Conversion in a Gliding Arc Plasmatron: Multidimensional Modeling for Improved Efficiency (2017)

The gliding arc plasmatron (GAP) is a highly efficient atmospheric plasma source, which is very promising for CO2 conversion applications. To understand its operation principles and to improve its application, we present here comprehensive modeling results, obtained by means of computational fluid dynamics simulations and plasma modeling. Because of the complexity of the CO2 plasma, a full 3D plasma model would be computationally impractical. Therefore, we combine a 3D turbulent gas flow model with a 2D plasma and gas heating model in order to calculate the plasma parameters and CO2 conversion characteristics. In addition, a complete 3D gas flow and plasma model with simplified argon chemistry is used to evaluate the gliding arc evolution in space and time. The calculated values are compared with experimental data from literature as much as possible in order to validate the model. The insights obtained in this study are very helpful for improving the application of CO2 conversion, as they allow us to identify the limiting factors in the performance, based on which solutions can be provided on how to further improve the capabilities of CO2 conversion in the GAP.
Survivable routing of logical topologies in WDM networks (2002)

Network restoration is often done at the electronic layer by rerouting traffic along a redundant path. With wavelength division multiplexing (WDM) as the underlying physical layer, it is possible that both the primary and backup paths traverse the same physical links and would fail simultaneously in the event of a link failure. It is therefore critical that lightpaths are routed in such a way that a single link failure would not disconnect the network. We call such a routing survivable and develop algorithms for survivable routing of a logical topology. We prove necessary and sufficient conditions for a routing to be survivable and use this condition to formulate the problem as an integer linear program. We use our new formulation to route various logical topologies over a number of different physical topologies and show that this new approach offers a much greater degree of protection than alternative routing schemes such as shortest path routing and a greedy routing algorithm.