gebhart/patrepeval huggingface dataset:
Identification of a Novel Pathway That Selectively Modulates Apoptosis of Breast Cancer Cells (2009)

Expression of the nuclear receptor interacting factor 3 (NRIF3) coregulator in a wide variety of breast cancer cells selectively leads to rapid caspase-2-dependent apoptotic cell death. A novel death domain (DD1) was mapped to a 30-amino acid region of NRIF3. Because the cytotoxicity of NRIF3 and DD1 seems to be cell type-specific, these studies suggest that breast cancer cells contain a novel "death switch" that can be specifically modulated by NRIF3 or DD1. Using an MCF-7 cell cDNA library in a yeast two-hybrid screen, we cloned a factor that mediates apoptosis by DD1 and refer to this factor as DD1-interacting factor-1 (DIF-1). DIF-1 is a transcriptional repressor that mediates its effect through SirT1, and this repression is attenuated by the binding of NRIF3/DD1. DIF-1 expression rescues breast cancer cells from NRIF3/DD1-induced apoptosis. Small interfering RNA (siRNA) knockdown of DIF-1 selectively leads to apoptosis of breast cancer cells, further suggesting that DIF-1 plays a key role in NRIF3/DD1-mediated apoptosis. A protein kinase A inhibitor (H89) also elicits apoptosis of breast cancer cells but not of the other cell types examined, and DIF-1 also protects these cells from H89-mediated apoptosis. In addition, H89 incubation results in a rapid increase in NRIF3 levels and siRNA knockdown of NRIF3 protects breast cancer cells from H89-mediated apoptosis. Our results indicate that DIF-1 plays a key role in breast cancer cell survival and further characterizing this pathway may provide important insights into developing novel therapies to selectively target breast cancer cells for apoptosis.
Advance in Quadraphonic Matrix Broadcasting (1977)

TMStereo-and mono-compatible stereo-quadraphonic (SQ) "matrix" recording and broadcasting is in wide use in the U.S.A. and abroad. Nevertheless, arguments continue about the need for "discrete" recording and broadcasting because of implied improvement they afford in channel separation and in artistic freedom in the use of the four channels. Both of these inferences are adduced to be fallacious. SQ quadraphonic broadcasting in the form of SQ records, syndicated productions, and encoded four-channel sources followed by full-logic decoding at the receiver end meets the identified needs of quadraphony. Two new advances are described in this paper: the SQ Ghent Microphone System which, from a single point in space is capable of picking up and transmitting a stereo-and mono-compatible pair of signals replicating the original directional performance either of the ambiance or surround-sound type, and a center-back "London Box" signal processor which encodes a stereo-and mono-compatible center-back signal and allows it appropriately to be decoded in the quadrilateral space with an SQ decoder.
Zeolitic Imidazolate Frameworks for Kinetic Separation of Propane and Propene (2009)

Propane/propene separation by cryogenic distillation is one of the most energy and cost intensive industrial processes. Adsorptive separation is a more energy-efficient alternative. Three isostructural zinc imidazolate zeolitic framework materials are found, for the first time, to be very promising in the separation of propene and propane based on their different diffusion rates. Fine-tuning of the pore opening size is critical for this type of separation.
Reciprocating optical modulator with resonant modulating electrode (2005)

A reciprocating optical modulator consisting of two optical filters and an optical phase modulator that has a resonant electrode to enhance modulation efficiency at a particular frequency is proposed. Lightwave reciprocates in the modulator, where the optical phase modulator placed between the two optical filters acts both on forward and backward lightwaves.
Advanced Crash Avoidance Technologies Program – Final Report of the Honda-DRI Team Volume IV: SIM Users Manual (2011)

The Advanced Crash Avoidance Technologies (ACAT) program initiated by the National Highway Traffic Safety Administration had two major objectives. These are to develop a standardized Safety Impact Methodology (SIM) tool to evaluate the effectiveness of advanced technologies in mitigating specific types of vehicle crash avoidance crashes; and to develop and demonstrate objective tests that are used in the SIM to verify the safety impact of a real system. Honda and Dynamic Research Inc. (DRI) had been developing and applying such a SIM for several years and DRI with Honda's support entered into a Cooperative Agreement with NHTSA to extend the existing SIM, which provides an estimate of full systems safety benefits at the US level. Objective tests that produce quantifiable, repeatable and reproducible results were developed to ensure that a crash avoidance countermeasure meets system performance specifications, and that the results are directly linked to the safety needs and sample of technology-relevant crashes being addressed. The objective tests, which are based on dynamic reconstructions of a sub-sample of technology-relevant real crashes, include Track tests with an expert driver using automatically guided soft targets (GSTs) of an automobile and of a pedestrian; and Driving Simulator tests with a jury of 12 typical drivers, in order to evaluate driver-vehicle system response and to measure the driver's and vehicle's response characteristics to system warnings and interventions. Results from the objective tests were used to parameterize, calibrate and validate the SIM tool, which was then used to estimate US-level benefits. The delivered SIM tool includes modules for automated reconstruction of conflict and crash scenarios from available databases; definition and sampling of Technology Relevant Crash Types; dynamic simulations involving a human-vehicle-device-environmental model; and an overall safety effects estimator. An example application of the extended SIM tool and developed objective tests involved evaluation of Honda’s prototype Advanced Collision Mitigation Brake System (A-CMBS).
PZT thin film bulk acoustic wave resonators and filters (2002)

Thin Film Bulk Acoustic Wave Resonators (FBAR) using Lead Zirconate Titanate (PZT) thin films as the piezoelectric active layer are favourable for voltage controlled oscillators and wide band filters due to the large electro-mechanical coupling coefficient of PZT. This paper reports the fabrication process and results of PZT FBARs and filters. The temperature coefficient and bias voltage effect are also presented.
Oculo-Vestibular Recoupling Using Galvanic Vestibular Stimulation to Mitigate Simulator Sickness (2012)

When virtual head signals produced by GVS are synchronized to the speed and direction of a moving visual field, manifestations of induced SS in a cockpit flight simulator are significantly reduced.
Method of controlling transmission capacity of a direct-coupling mechanism in hydraulic power transmission (1987)

A method is described of controlling a direct-coupling mechanism of a hydraulic power transmission means having an input member and an output member, of an automatic transmission for an automotive vehicle. The direct-coupling mechanism is operable to mechanically engage and disengage the input member and the output member with and from each other. The automatic transmission has selector means being operatable at human will to select among operating modes in which the automotive vehicle is to be operated, wherein the transmission capacity of the direct-coupling mechanism is controlled such that the value of a first predetermined parameter indicative of an amount of relative slip between the input member and the output member lies within a predetermined reference range. The method comprises the steps of: (1) detecting the value of a second predetermined parameter indicative of one of the operating modes selected by the selector means; and (2) determining the predetermined reference range of the value of the first predetermined parameter in dependence on the detected value of the second predetermined parameter.
Characterization of the interference coupling technique into single mode fibers (2003)

Summary from only given. We propose a comparison of the single beam and the interference coupling schemes into single mode fibers. Coupling efficiency calculations, based on the overlapping integrals of the fiber mode field and the distribution of the input fight intensity are presented. This study takes into account the light coupling and propagation in the fiber core and cladding.
JUXTACRINE STIMULATION OF NORMAL AND MALIGNANT HUMAN BLADDER EPITHELIAL CELL PROLIFERATION (2002)

LA7 feeder cells stimulate human bladder cell proliferation for many generations in culture by a juxtacrine mechanism and promote the expression of differentiated traits.
<title>Wavelet-based hyperspectral image coding using robust fixed-rate trellis-coded quantization</title> (1998)

A system is presented for compression of hyperspectral imagery. Specifically, DPCM is used for spectral decorrelation, while a robust 2-D discrete wavelet coding scheme is used for spatial decorrelation. Trellis-coded quantization is used to encode the wavelet coefficients. Side information and rate allocation strategies are discussed. Fixed-rate codebooks are designed using a modified version of the generalized Lloyd algorithm. This system achieves a compression ratio of greater than 70:1, with an average PSNR of the coded hyperspectral sequence exceeding 40 dB.
Capacity Analysis For Orthogonal Halftone Orientation Modulation Channels (2011)

Halftone dot orientation modulation has recently been proposed as a method for data hiding in printed images. Extraction of data embedded with halftone orientation modulation is accomplished by computing, from the scanned hardcopy image, detection statistics that uniquely identify the embedded orientation. From a communications perspective, this data hiding setup forms an interesting class of channels with dot orientation as input and a vector of statistics as the output. This paper derives capacity expressions for these channels that allow for numerical evaluation of the capacity. Results provide significant insight for orientation modulation based print-scan resilient data hiding: the capacity varies significantly as a function of the image graylevel and experimentally observed error free data rates closely mirror the variation in capacity.
Toluene steam reforming as tar model molecule produced during biomass gasification with an iron/olivine catalyst (2010)

Tar produced during biomass steam reforming is a complex mixture of single to multiple ring aromatic compounds and it is necessary to eliminate them in order to prevent any condensation-polymerisation problem. Tar steam reforming leads to additional hydrogen that improves gas production. Previous works have shown that olivine was active in tar removal during biomass gasification and the iron distribution into the mineral different phases has a real influence on its efficiency. A Fe/olivine catalytic system has been designed to study tar steam reforming. This work presents the Fe/olivine catalyst characterizations (XRD, Mössbauer, TPR) and compares the Fe/olivine and olivine reactivity in toluene steam reforming, a tar model molecule. At 850 °C, an important conversion (95%) was observed for Fe/olivine during 7 h. The strong interaction between iron and olivine, and the equilibrium between Fe 0 /Fe II /Fe III seem to be responsible of the catalyst activity and stability in toluene steam reforming.
Gravity Inflow Performance Relationship for SAGD Production Wells (2016)

Abstract This paper presents the formulation and verification of a simple model for predicting the liquid level above steam-assisted gravity drainage (SAGD) production wells. Controlling the proximity of the liquid-vapour interface to the producer is paramount for maximizing the energy efficiency of SAGD, optimizing production, and reducing the risk of liner damage from steam breakthrough; and so a simple model can be used for quick approximation and potentially for decisions on wellbore design and operational control. The formulation is based on continuity of mass flow and thermal behaviour. Darcy's law is the key phenomenon in formulating an analytical model of the flow through the liquid pool, or steam trap, around the production well, which is referred to in this work as a gravity inflow performance relationship (GIPR). The GIPR relates the liquid level above the producer to the inflow rate, system pressures, and reservoir and fluid properties. To validate our modelling assumptions, the liquid level predicted by the GIPR is compared to data generated from a commercial reservoir simulator for a wide range of operating conditions. Based on data from 31 reservoir simulations, the GIPR predicts the liquid level with high accuracy. The liquid levels given by the GIPR and reservoir simulator differ by a root-mean-square error of only 0.23 m. The introduction of a correction factor in the GIPR reduces the root-mean-square error to just 0.17 m. Moreover, the GIPR reveals fundamental relationships between the liquid level and SAGD process variables, providing insight into the mechanics of steam trap control. The relationship between the liquid level and the inflow rate yields a criterion for the stability of the liquid-vapour interface above the production well. The criterion elucidates the conditions under which the position of the liquid-vapour interface will be unstable and, thus, the conditions under which steam breakthrough or injector flooding may be expected. The GIPR provides a simple, efficient, and accurate way to predict the liquid level above SAGD production wells, enabling the optimization of well designs and control strategies to facilitate steam trap control. In addition, the GIPR reveals relationships between variables that are masked with more complex models, providing an enhanced understanding of the SAGD process.
Quantum Dot IR Photodetectors and Solar Cells Enhanced by Built-in Charge (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation V. Mitin, A. Sergeev, N. Vagidov, K. A. Sablon, J. W. Little; Quantum Dot IR Photodetectors and Solar Cells Enhanced by Built‐in Charge. AIP Conference Proceedings 26 December 2011; 1416 (1): 52–55. https://doi.org/10.1063/1.3671696 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry. (1990)

The combination of microdialysis and fast-atom bombardment mass spectrometry has been used to follow the pharmacokinetics of penicillin G directly in the blood-stream of a live rat. After the intramuscular injection of the antibiotic, the blood dialysate was allowed to flow into the mass spectrometer via the continuous-flow/fast-atom bombardment interface. Tandem mass spectrometry provided the means for isolating and recording the ion fragments produced from the drug as the dialysate was exposed to the ionization process. The pharmacokinetic results obtained are compared with those previously reported in the literature, and this on-line method is discussed in terms of its particular advantages.
Hierarchical Mobile IPv6 Mobility Management (HMIPv6) (2005)

This document introduces extensions to Mobile IPv6 and IPv6 Neighbour Discovery to allow for local mobility handling.Hierarchical mobility management for Mobile IPv6 is designed to reduce the amount of signalling between the Mobile Node, its Correspondent Nodes, and its Home Agent.The Mobility Anchor Point (MAP) described in this document can also be used to improve the performance of Mobile IPv6 in terms of handover speed.
Comparison of conventional and collapsed region operation of capacitive micromachined ultrasonic transducers (2006)

We report experimental results from a comparative study on collapsed region and conventional region operation of capacitive micromachined ultrasonic transducers (CMUTs) fabricated with a wafer bonding technique. Using ultrasonic pulse-echo and pitch-catch measurements, we characterized single elements of 1-D CMUT arrays operating in oil. The experimental results from this study agreed with the simulation results: a CMUT operating in the collapsed region produced a higher maximum output pressure than a CMUT operated in the conventional region at 90% of its collapse voltage (3 kPa/V vs. 16.1 kPa/V at 2.3 MHz). While the pulse-echo fractional bandwidth (126%) was higher in the collapsed region operation than in the conventional operation (117%), the pulse-echo amplitude in collapsed region operation was 11 dB higher than in conventional region operation. Furthermore, within the range of tested bias voltages, the output pressure monotonously increased with increased bias during collapsed region operation. It was also found that in the conventional mode, short AC pulses (larger than the collapse voltage) could be applied without collapsing the membranes. Finally, while no significant difference was observed in reflectivity of the CMUT face between the two regions of operation, hysteretic behavior of the devices was identified in the collapsed region operation.
High-Speed X-Cut Thin-Sheet $\hbox{LiNbO}_{3}$ Optical Modulator With Folded Structure (2007)

We propose a small-footprint X-cut thin-sheet lithium niobate optical modulator with high-speed and low-driving-voltage characteristics. Since an optical waveguide is folded by a mirror placed at one edge of the modulation chip, the chip can be shortened by about half. In addition, a wide modulation bandwidth can be achieved, because the path-length difference between the optical waveguide and the coplanar-waveguide (CPW) electrode is decreased to as short as possible by placing the CPW electrode as far as possible along the optical waveguide in the folded portion, and the microwave effective index is set to realize effective velocity matching between the lightwave and the microwave. A small footprint of 1.78 times 29 mm, a low half-wave voltage of 2.0 V at dc, and a 3-dBe modulation bandwidth of 20 GHz were obtained.
Application of control theory principles to optimization of grain size during hot extrusion (1998)

Modern control theory has been applied to the optimisation of microstructure development during hot extrusion. This approach involves state space type models for describing the material behaviour and the mechanics of the process. The problem of determining process control parameters such as strain, strain rate, and temperature to obtain prespecified microstructural features can be systematically formulated in terms of an optimal control problem. This method has been applied to the optimisation of grain size and certain process parameters such as die geometry and ram velocity during extrusion of plain carbon steel. Experimental results of this investigation show good agreement with those predicted in the design stage.
Effects of Silica on the Combustion Synthesis and Glass Formation of TiB <sub>2</sub> ‐Containing Calcium Aluminate Matrix Composites (2005)

Combustion synthesis has been used to study the combustion characteristics and microstructure in the TiB 2 –CaO–Al 2 O 3 –SiO 2 system. Both the combustion temperature and wave velocity decreased with an increase in the amount of silica. The reacted product consisted of solid crystalline TiB 2 phase and CaO–Al 2 O 3 –SiO 2 matrix. No significant reaction between the TiB 2 and the matrix was observed. It was found that the binary calcium aluminate matrix (Ca 12 Al 7 O 33 and CaAl 2 O 4 compounds) could form amorphous phase (glass) at a high cooling rate. Under a normal cooling rate, significant formation of glass in the matrix was found possible only by adding another glass‐former, e.g., silica (SiO 2 ). The addition of SiO 2 led to the formation of Gehelenite, to the reduction of the other crystal phases and to an increase in the glass phase in the matrix. A pure glass matrix was obtained for all compositions in the composition range from Ca 12 Al 7 O 33 to CaAl 2 O 4 compounds provided that an adequate amount of SiO 2 was added. The resulting glass matrix can be expressed by the formula Ca 2 (Si x Al 1− x ) 3 O, where x =0.32–0.58, depending on the composition. Effects of the TiB 2 phase on the combustion synthesis process and on the microstructure are also discussed. TiB 2 increased the reactivity and led to the formation of the molten matrix which was critical for glass formation. However, its effects on the vitrification of the matrix was considered to be minimum. The mechanism of glass formation in the matrix is discussed using the Zachariasen–Warren network theory.
Atmospheric-pressure plasma cleaning of contaminated surfaces. 1998 annual progress report (1998)

'The object of this research program is to develop an atmospheric-pressure plasma jet for converting transuranic wastes (TRUs) into low-level radioactive wastes (LLWs). This plasma process will be used to efficiently decontaminate a wide range of structures and equipment. This report summarizes work after 1 year and 9 months of a 3-year project. A picture of the atmospheric-pressure plasma jet is shown in Fig. 1. This new plasma source consists of two concentric electrodes through which a mixture of helium and reactive gases flow. The plasma is ignited by applying 13.56 MHz RF power to the inner electrode. The characteristics of this discharge are different from other atmospheric-pressure plasmas, such as transferred arcs, torches, coronas and silent discharges. Shown in Fig. 2 is the current-voltage curve for the plasma jet. Spark breakdown occurs at 0.01 A, and is proceeded by a normal glow region, in which the voltage remains constant with increasing current, and an abnormal glow region, in which the voltage increases rapidly with current. At about 1.0 A and 225 V, the plasma begins to arc. The normal glow region is rarely observed in atmospheric pressure plasmas. They usually proceed directly from spark breakdown to arcing. The trend shown in the figure indicates that the plasma jet is stable over a wide range of operating conditions. The distribution of reactive species in a plasma jet, containing oxygen and helium, has been characterized by Langmuir probe measurements, optical emission spectroscopy, and ultraviolet absorption spectroscopy. The charged particle density ranges from about 5 x 10{sup 11} cm{sup -3} inside the plasma to 1 x 10{sup 10} cm{sup -3} in the jet exit. The concentration of metastable oxygen molecules (a 1 Dg and b 1 Sg{sup +} ) is estimated to be between 10{sup 12} to 10{sup 13} cm{sup -3} . By contrast, the ozone concentration increases from about 5 x 10{sup 14} cm{sup -3} inside the plasma to 1 x 10{sup 16} cm{sup -3} in the effluent. The ozone molecules are produced by the reaction of O atoms with O{sub 2} molecules: O + O{sub 2} + M a O{sub 3} + M. To generate the amount of ozone observed, the O atom concentration in the plasma must be near 1 x 10{sup 16} cm{sup -3}, or about 10% of the oxygen fed. These results are quite unexpected, because most non-equilibrium, low-temperature plasmas achieve a much lower degree of dissociation. The etching of actinide metals has been simulated by using tantalum as a surrogate material. Tantalum etching rates of up to 1.2 mm/min are achieved with the plasma jet using a CF{sub 4}/O{sub 2}/He gas feed. This is 10 times faster than conventional plasma systems, and indicates that the atmospheric-pressure plasma is a promising technology for decontamination of DOE sites. Finally, the plasma jet has been successfully modified to process larger areas, up to about 1.0 ft{sup 2} . Work is underway to increase the process scale further. The authors are confident that this technology is capable of being adapted for decontamination operations in the field.'