gebhart/patrepeval huggingface dataset:
Genetic Markers in the Clinical Care of Head and Neck Cancer (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Otolaryngology–Head & Neck Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Otolaryngology–Head & Neck Surgery journal
Acute Middle East Respiratory Syndrome Coronavirus: Temporal Lung Changes Observed on the Chest Radiographs of 55 Patients (2015)

Ground-glass opacity in a peripheral location was the most common abnormality noted on chest radiographs. A higher chest radiographic score coupled with a high number of medical comorbidities was associated with a poor prognosis and higher mortality in those infected with MERS-CoV. Younger HCWs with few or no comorbidities had a higher survival rate.
The vehicle platoon controller in the decentralised, autonomous intersection management of vehicles (2004)

The vehicle platoon controller to be presented here plays an important part in the latest generation of the decentralised, autonomous intersection management. It is the executing instance in the intersection management and combines the results from different optimisations done by the vehicles on their way into the intersection in order to ensure optimum crossing of the intersection. To do so it must not only be platoon-stable but also have an enlarged functionality in comparison to a conventional platoon controller. In the following we present all relevant aspects for the design of the platoon controller and its use in simulations of the intersection management.
Establishment of X-linked Alport syndrome model mice with a Col4a5 R471X mutation (2018)

Alport syndrome (AS) is an inherited disorder characterized by glomerular basement membrane (GBM) abnormality and development of chronic kidney disease at an early age. The cause of AS is a genetic mutation in type IV collagen, and more than 80% of patients have X-linked AS (XLAS) with mutation in COL4A5. Although the causal gene has been identified, mechanisms of progression have not been elucidated, and no effective treatment has been developed. In this study, we generated a Col4a5 mutant mouse harboring a nonsense mutation (R471X) obtained from a patient with XLAS using clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated system. Col4a5 mRNA and protein expressions were not observed in the kidneys of hemizygous R471X male mice. R471X mice showed proteinuria and hematuria. Pathology revealed progression of glomerulosclerosis and interstitial fibrosis by age. Electron microscopy identified irregular thickening in GBM accompanied by irregular lamination. These observations were consistent with the clinical and pathological features of patients with AS and other established models. In addition, our mice models develop end-stage renal disease at the median age of 28 weeks, much later compared to previous models much more consistent with clinical course of human XLAS. Our models have advantages for future experiments in regard with treatment for human XLAS. Keywords: Col4a5, Alport syndrome, XLAS, CKD, ESRD, Model mice
A Method for Establishing Routes and IPv6 Addressing Based on the Estimated Distance from Neighboring Nodes in Wireless Mesh Networks (2013)

As networks for providing wireless access easily and inexpensively with high robustness against network node failures, wireless mesh networks have been expected in recent years. However, wireless mesh networks consume numerous control packets to establish transmission routes and the number of control packets greatly exceeds that of conventional wireless network environments. Opportunities for packet collision will therefore increase as a result. Our research group has made progress in research based on the locations of mesh points to decrease the number of control packets needed to establish routes. This information about the locations of mesh points is offered to neighboring mesh points. We define a virtual space and an IPv6 address specification including information of each mesh point location. In this paper, we introduce a method for establishing routes and an IPv6 addressing specification in detail.
Quantitative Mapping of Structured Polymeric Systems Using Singular Value Decomposition Analysis of Soft X-ray Images (2002)

The distribution of poly(acrylic acid) in a microporous polypropylene support membrane has been measured quantitatively by scanning transmission X-ray microscopy (STXM). Singular value decomposition analysis of X-ray microscopy images recorded at carefully selected photon energies was used to obtain quantitative maps of the polypropylene membrane and the poly(acrylic acid) gel, the two components of this system. The sample was studied fully hydrated in order to perform the quantitative mapping when the membrane is the same as in its state of application. Optimum strategies of data acquisition for quantitative X-ray microscopy analysis of radiation sensitive materials are discussed, along with a brief comparison of this technique to alternative methods of mapping the chemical components of structured multicomponent polymeric systems.
A Highly Conserved Effector in <i>Fusarium oxysporum</i> Is Required for Full Virulence on <i>Arabidopsis</i> (2011)

Secreted-in-xylem (SIX) proteins of the vascular wilt pathogen Fusarium oxysporum f. sp. lycopersici are secreted during infection of tomato and function in virulence or avirulence. F. oxysporum formae speciales have specific host ranges but the roles of SIX proteins in diverse hosts are unknown. We identified homologs of F. oxysporum f. sp. lycopersici SIX1, SIX4, SIX8, and SIX9 in the genome of Arabidopsis infecting isolate Fo5176. A SIX4 homolog (termed Fo5176-SIX4) differed from that of F. oxysporum f. sp. lycopersici (Fol-SIX4) by only two amino acids, and its expression was induced during infection of Arabidopsis. Transgenic Arabidopsis plants constitutively expressing Fo5176-SIX4 had increased disease symptoms with Fo5176. Conversely, Fo5176-SIX4 gene knock-out mutants (Δsix4) had significantly reduced virulence on Arabidopsis, and this was associated with reduced fungal biomass and host jasmonate-mediated gene expression, the latter known to be essential for host symptom development. Full virulence was restored by complementation of Δsix4 mutants with either Fo5176-SIX4 or Fol-SIX4. Thus, Fo5176-SIX4 contributes quantitatively to virulence on Arabidopsis whereas, in tomato, Fol-SIX4 acts in host specificity as both an avirulence protein and a suppressor of other race-specific resistances. The strong sequence conservation for SIX4 in F. oxysporum f. sp. lycopersici and Fo5176 suggests a recent common origin.
Optimal source distribution for binaural synthesis over loudspeakers (2001)

When binaural sound signals are presented with loudspeakers, the system inversion involved gives rise to a number of problems such as a loss of dynamic range and a lack of robustness to small errors of control performance. These problems for such systems are investigated and a new system concept is proposed. The system overcomes these fundamental problems by means of a conceptual pair of monopole transducers whose span varies continuously as a function of frequency. A practical solution for the realization of a variable transducer span by discretization is also described.
Digital rights management in a 3G mobile phone and beyond (2003)

In this paper we examine how copyright protection of digital items can be securely managed in a 3G mobile phone and other devices. First, the basic concepts, strategies, and requirements for digital rights management are reviewed. Next, a framework for protecting digital content in the embedded environment of a mobile phone is proposed and the elements in this system are defined. The means to enforce security in this system are described and a novel "Family Domain" approach to content management is introduced. Our new approach uses key sharing to help alleviate bad user experiences that are associated with some rights management systems. Examples outlining the enrollment of devices and the acquisition, rendering, and superdistribution of content are shown. Our proposed system is not only applicable to a mobile phone system, but may also be extended to other embedded systems, such as personal digital assistants, set-top boxes, or personal computers.
Pacemaker Diagnostic Diagrams (1985)

Dual-chamber pacemakers interact with cardiac rhythms in complex ways. The resultant surface electrocardiograms (ECGs) are often very difficult to interpret. A simple and automatic diagnostic diagram is described that graphically illustrates pacemaker-heart interactions. Pacemaker operation is explained by a continuous series of lines and symbols that interconnect any sequence of paced and sensed events in both chambers. Fixed, programmable, and adaptive pacemaker timing intervals are all shown in a simple format. The pacemaker diagnostic diagram is plotted directly below the ECG to help users interpret the paced cardiac rhythm. The pacemaker diagnostic diagram is generated by software in a pacemaker programmer from: (1) telemetered real-time event markers; (2) fixed and programmable timing parameters (lower rate, AV interval, etc.); (3) pacemaker conditional logic. If this computer analysis of the telemetered event markers is not consistent with normal pacemaker operation, a specific error-message is printed. The pacemaker diagnostic diagram should be useful for instruction, pacemaker follow-up, and troubleshooting.
Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia (2006)

Because antiangiogenic therapies inhibit the growth of new tumor-associated blood vessels, as well as prune newly formed vasculature, they would be expected to reduce the supply of oxygen and thus increase tumor hypoxia. However, it is not clear if antiangiogenic treatments lead only to consistent and sustained increases in hypoxia, or transient decreases in tumor hypoxia along with periods of increased hypoxia. We undertook a detailed analysis of an orthotopically transplanted human breast carcinoma (MDA-MB-231) over a 3-week treatment period using DC101, an anti-vascular endothelial growth factor receptor 2 antibody. We observed consistent reductions in microvascular density, blood flow (measured by high-frequency micro-ultrasound), and perfusion. These effects resulted in an increase in the hypoxic tumor fraction, measured with an exogenous marker, pimonidazole, concurrent with an elevation in hypoxia-inducible factor-1alpha expression, an endogenous marker. The increase in tumor hypoxia was evident within 5 days and remained so throughout the entire course of treatment. Vascular perfusion and flow were impaired at days 2, 5, 7, 8, 14, and 21 after the first injection, but not at 4 hours. A modest increase in the vessel maturation index was detected after the 3-week treatment period, but this was not accompanied by an improvement in vascular function. These results suggest that sustained hypoxia and impairment of vascular function can be two consistent consequences of antiangiogenic drug treatment. The implications of the results are discussed, particularly with respect to how they relate to different theories for the counterintuitive chemosensitizing effects of antiangiogenic drugs, even when hypoxia is increased.
Increased Metastatic Dissemination in Human Melanoma Xenografts after Subcurative Radiation Treatment (2004)

Cancer patients showing local failure after radiation treatment have increased probability for developing metastatic disease. The mechanisms behind this observation have not been identified. In the present work, metastatic spread after inadequate radiation therapy was studied by using R-18 human melanoma xenografts as models of cancer in humans. Pimonidazole was used as a hypoxia marker, and hypoxia and urokinase-type plasminogen activator receptor (uPAR) expression were detected by immunohistochemistry. R-18 tumors regrowing after subcurative irradiation showed a higher frequency of lymph node metastasis than unirradiated tumors. The expression of uPAR was up-regulated in hypoxic tumor regions, and the fractions of hypoxic and uPAR-positive cells were approximately 2-fold higher in regrowing irradiated tumors than in untreated tumors. Treatment with anti-uPAR antibody blocked metastasis almost completely in irradiated as well as unirradiated tumors. The metastatic frequency was higher in tumors regrowing after irradiation than in unirradiated tumors because the irradiation induced tumor hypoxia, and tumor hypoxia induced up-regulation of uPAR.
Characterization of strained InGaAs single quantum well structures by ion beam methods (1990)

We have investigated strained InGaAs single quantum well structures using MeV ion beam methods. The structural properties of these structures, including composition and well size, have been studied. It has been found that the composition obtained by Rutherford backscattering spectrometry and particle-induced x-ray emission techniques agrees very well with that obtained by the ion channeling method.
High-Throughput Big Data Analytics Through Accelerated Parquet to Arrow Conversion (2019)

With the advent of high-bandwidth non-volatile storage devices, the classical assumption that database analytics applications are bottlenecked by CPUs having to wait for slow I/O devices is being flipped around. Instead, CPUs are no longer able to decompress and deserialize the data stored in storage-focused file formats fast enough to keep up with the speed at which compressed data is read from storage. In order to better utilize the increasing I/O bandwidth, this work proposes a hardware accelerated approach to converting storage-focused file formats to in-memory data structures. To that end, an FPGA-based Apache Parquet reading engine is developed that utilizes existing FPGA and memory interfacing hardware to write data to memory in Apache Arrow's in-memory format. A modular and expandable hardware architecture called the ParquetReader with out-of-the-box support for DELTA_BINARY_PACKED and DELTA_LENGTH_BYTE_ARRAY encodings is proposed and implemented on an Amazon EC2 F1 instance with an XCVU9P FPGA.<br/> <br/>The ParquetReader has great area efficiency, with a single ParquetReader only requiring between 1.18% and 2.79% of LUTs, between 1.27% and 2.92% of registers and between 2.13% and 4.47% of BRAM depending on the targeted input data type and encoding. This area efficiency allows for instantiating a large number of (possibly different) ParquetReaders for parallel workloads. Multiple Parquet files of varying types and encodings were generated in order to measure the performance of the ParquetReaders. A single engine has achieved up to 2.81x speedup for DELTA_LENGTH_BYTE_ARRAY encoded strings and 2.79x speedup for DELTA_BINARY_PACKED integers when compared to CPU-only Parquet reading implementations, attaining a throughput between 2.3 GB/s and 7.2 GB/s (limited by the interface bandwidth of the testing system) depending on the input data. The high throughput and low resource utilization of the ParquetReader allow for the interface bandwidth to be saturated using multiple ParquetReaders utilizing only a small amount of the FPGA's resources.
Characterization and modeling of second breakdown in NMOST's for the extraction of ESD-related process and design parameters (1991)

A technique is presented to determine the effective process and design-related parameters from the high-current I-Vcharacteristics of NMOSTs, for use in the development of electrostatic discharge (ESD) protection circuits. Test structures from a fully salicided, LDD MOS process were characterized with a transmission line pulse generator to obtain the snapback voltages and the second-breakdown trigger currents (I/sub t2/) Good correlations are shown between I/sub t2/ and the human body model (HBM) ESD damage thresholds. It was seen that homogeneous current injection in the avalanching diffusions is imperative for good second breakdown behavior. A simplified thermal model, with second breakdown as the boundary condition for damage, was used in the extraction of the effective junction depth, depletion width, and transistor width under high-current conditions. Experimental data obtained for the power-to-failure as a function of the time-to-failure showed a good fit to the model. A possible extension of the technique for the use of DC characterization to monitor ESD behavior is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment (2020)

Despite advances in molecularly characterizing glioblastoma (GBM), metabolic alterations driving its aggressive phenotype are only beginning to be recognized. Integrative cross-platform analysis coupling global metabolomic and gene expression profiling on patient-derived glioma identified fatty acid β-oxidation (FAO) as a metabolic node in GBM. We determined that the biologic consequence of enhanced FAO is directly dependent upon tumor microenvironment. FAO serves as a metabolic cue to drive proliferation in a β-HB/GPR109A dependent autocrine manner in nutrient favorable conditions, while providing an efficient, alternate source of ATP only in nutrient unfavorable conditions. Rational combinatorial strategies designed to target these dynamic roles FAO plays in gliomagenesis resulted in necroptosis-mediated metabolic synthetic lethality in GBM. In summary, we identified FAO as a dominant metabolic node in GBM that provides metabolic plasticity, allowing these cells to adapt to their dynamic microenvironment. Combinatorial strategies designed to target these diverse roles FAO plays in gliomagenesis offers therapeutic potential in GBM.
Transcription in vitro of Infectious Haematopoietic Necrosis Virus, a Fish Rhabdovirus (1987)

Transcription in vitro by the RNA polymerase of infectious haematopoietic necrosis virus (IHNV), a salmonid rhabdovirus, was investigated using different reaction conditions to maximize RNA synthesis. The use of HEPES buffer rather than Tris buffer, and the addition of S-adenosyl-L-methionine to the reactions resulted in a sixfold increase in RNA synthetic activity to 6400 pmol UMP incorporated/mg viral protein/hour. The RNA transcripts produced in this system contained polyadenylated species which co-migrated with IHNV mRNA species 2, 3, 4 and 5 from IHNV-infected cells. The transcripts were shown to be functional mRNA species by their ability to direct the synthesis of viral proteins in vitro.
A simple statistical method for measuring how life events affect happiness (2002)

We believe that the new statistical method has many applications. In principle, it can be used to value any kind of event in life.
Compressed sensing and sparsity in photoacoustic tomography (2016)

Increasing the imaging speed is a central aim in photoacoustic tomography. This issue is especially important in the case of sequential scanning approaches as applied for most existing optical detection schemes. In this work we address this issue using techniques of compressed sensing. We demonstrate, that the number of measurements can significantly be reduced by allowing general linear measurements instead of point-wise pressure values. A main requirement in compressed sensing is the sparsity of the unknowns to be recovered. For that purpose, we develop the concept of sparsifying temporal transforms for three-dimensional photoacoustic tomography. We establish a two-stage algorithm that recovers the complete pressure signals in a first step and then apply a standard reconstruction algorithm such as back-projection. This yields a novel reconstruction method with much lower complexity than existing compressed sensing approaches for photoacoustic tomography. Reconstruction results for simulated and for experimental data verify that the proposed compressed sensing scheme allows for reducing the number of spatial measurements without reducing the spatial resolution.
Tunable dipole antennas (2002)

The concept of extending the operating bandwidth of a dipole has been investigated, and two bandwidth extension approaches were studied. The first approach involves the use of parasitic elements to physically change the length of the dipole. The second approach involves capacitively loading a dipole via varactor diodes to produce a travelling-wave dipole. Results are reported for the parasitic approach, which produces a broadband or multifrequency structure. The multifrequency antenna is controlled by an applied bias voltage. Simulations of the antenna showed the relationship between the diode junction capacitance and the isolation between the active and nonactive regions of the dipole.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Epsin Family of Endocytic Adaptor Proteins as Oncogenic Regulators of Cancer Progression (2013)

Tumor angiogenesis, tumor cell proliferation, and tumor cell migration result from an accumulation of oncogenic mutations that alter protein expression and the regulation of various signaling cascades. Epsins, a small family of clathrin-mediated endocytic adaptor proteins, are reportedly upregulated in a variety of cancers. Importantly, loss of epsins protects against tumorigenesis, thus supporting an oncogenic role for epsins in cancer. Although a clear relationship between epsins and cancer has evolved, the importance of this relationship with regards to cancer progression and anti-cancer therapies remains unclear. In this review, we summarize epsins' role as endocytic adaptors that modulate VEGF and Notch signaling through the regulated internalization of VEGFR2 and trans-endocytosis of Notch receptors. As both VEGF and Notch signaling have significant implications in angiogenesis, we focus on the newly identified role for epsins in tumor angiogenesis. In addition to epsins' canonical role in receptor-mediated endocytosis, and the resulting downstream signaling regulation, we discuss the non-canonical role of epsins as regulators of small GTPases and the implications this has on tumor cell proliferation and invasion. Given epsins' identified roles in tumor angiogenesis, tumor cell proliferation, and tumor cell invasion, we predict that the investigative links between epsins and cancer will provide new insights into the importance of endocytic adaptors and their potential use as future therapeutic targets.