gebhart/patrepeval huggingface dataset:
Classification of existing mobile cross-platform approaches (2020)

Nowadays, smartphones occupy a large part of our lives; whether in our personal or professional life, with a variety of mobile applications proposed covering almost every area such as: social media, lifestyle, payment, utility, games and entertainment, productivity, news and information outlet, Enterprise specific-app, etc. The smartphone market has been growing up since 2007 when the first Apple phone appeared. Statistics made by Gartner show that Smartphone sales increased by more than 65% between the first quarter of 2012 and the third quarter of 2018[10]. According to the same statistics, since 2012, android has monopolized the mobile market with a part of 88% in 2018, the rest was taken by IOS and other OS, which cause problems for enterprises, whom want to, target all smartphone users, in other words all smartphone platforms. For that, cross-platform alternative comes to solve this problem with a variety of approaches in depend of the application and the target platform.
Facial biomechanics: The standards of normal (1985)

To quantify facial motor function during mimetic expressions, two new techniques were introduced in this study: linear measurement (LM) of skin landmarks and integrated electromyography (iEMG) of the facial musculature. Based on data from 30 normal subjects, three indices were derived to estimate total maximum motion, total maximum iEMG output, and the relationship between iEMG activity and motion. In three different facial expressions, plots of the logarithm of the iEMG value versus percent Displacement (pD) of skin landmarks had a high correlation (total mean r = 0.95). The normal LM and iEMG standards constitute a data base against which facial biomechanical properties in various pathologic states can be interpreted. In the course of data analysis, several interesting characteristics of facial function were identified.
Design of a Continuous Wave Heavy Ion RFQ for BISOL (2021)

The Beijing isotope separation online (BISOL) facility will be used to study the new physics and technologies at the limit of the nuclear stability. The post accelerator for BISOL facility aims to accelerate radioactive beams to 150MeV/u. As an injector for the downstream superconducting linac, a 4-vane RFQ operating at 81.25MHz is needed to accelerate high-charge-state ions such as 132Sn²²⁺ from 3keV/u to 500keV/u in CW mode. We have compared two kinds of beam dynamics of BISOL RFQ with and without a Multi-Harmonic Buncher (MHB) bunching the continuous wave beam up-stream of the RFQ. The results indicate that it is possible to keep transverse emittance growth within tolerable limits while the longitudinal emittance is much smaller than the design without an external buncher. The acceleration of multi-charge beams simultaneously in the RFQ is also discussed in this paper.
Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis (2018)

Corneal neovascularization is a sight-threatening condition caused by angiogenesis in the normally avascular cornea. Neovascularization of the cornea is often associated with an inflammatory response, thus targeting VEGF-A alone yields only a limited efficacy. The NF-κB signaling pathway plays important roles in inflammation and angiogenesis. Here, we study consequences of the inhibition of NF-κB activation through selective blockade of the IKK complex IκB kinase β (IKK2) using the compound IMD0354, focusing on the effects of inflammation and pathological angiogenesis in the cornea. In vitro, IMD0354 treatment diminished HUVEC migration and tube formation without an increase in cell death and arrested rat aortic ring sprouting. In HUVEC, the IMD0354 treatment caused a dose-dependent reduction in VEGF-A expression, suppressed TNFα-stimulated expression of chemokines CCL2 and CXCL5, and diminished actin filament fibers and cell filopodia formation. In developing zebrafish embryos, IMD0354 treatment reduced expression of Vegf-a and disrupted retinal angiogenesis. In inflammation-induced angiogenesis in the rat cornea, systemic selective IKK2 inhibition decreased inflammatory cell invasion, suppressed CCL2, CXCL5, Cxcr2, and TNF-α expression and exhibited anti-angiogenic effects such as reduced limbal vessel dilation, reduced VEGF-A expression and reduced angiogenic sprouting, without noticeable toxic effect. In summary, targeting NF-κB by selective IKK2 inhibition dampened the inflammatory and angiogenic responses in vivo by modulating the endothelial cell expression profile and motility, thus indicating an important role of NF-κB signaling in the development of pathologic corneal neovascularization.
Virtual Network Functions exploitation through a prototype resource management framework (2014)

This paper elaborates on the design of a prototype framework for the exploitation of virtual Network Functions (NFs) and virtual Network Resources (NRs) in a cloud-based network architecture. The proposed framework is based on a Marketplace approach, utilizing a centralized network architecture, where the exploitation of the available NFs/NRs is managed by a Brokerage Module. This Brokerage Module applies trading policies based on a resource predictive entity that monitors the resources, towards matching the end-user demands and providing the acceptable bandwidth required.
Comparison of Archival Plasma and Formalin-Fixed Paraffin-Embedded Tissue for Genotyping in Hepatocellular Carcinoma (2005)

Biobanks containing formalin-fixed paraffin-embedded tissue, as well as frozen serum or plasma, are important resources for molecular epidemiologic studies. However, few studies have compared the reliability of formalin-fixed tissue samples and archival plasma samples for genotyping. We determined the genotype of four proposed genetic risk factors for hepatocellular carcinoma [hereditary hemochromatosis (HFE 63 and 282), alpha(1)-antitrypsin deficiency (AAT 342) and cystic fibrosis (CFTR 508)] on formalin-fixed tissue samples, stored for up to 25 years, from 318 patients diagnosed with hepatocellular carcinoma and on plasma or serum samples from 31 of these patients. The genotypes were analyzed by RFLP or allele-specific amplification as well as by TaqMan assays. In addition, genotyping was attempted after whole genome amplification by multiple displacement amplification (MDA). Genotyping was successful in 94% of the tissue samples and successful and identical to the tissue samples from the same subjects in 98% of the plasma/serum samples. DNA from plasma samples could be amplified >5,000-fold by MDA and genotyping after MDA gave identical results to the genotyping of the same subjects before whole genome amplification. MDA amplification of the tissue samples was not successful. In summary, archival plasma was found to be an adequate source of efficiently amplifiable DNA. MDA on plasma samples allows analysis of multiple genotypes in epidemiologic studies.
Der Funktionsfragebogen Hannover (FFbH) und die Subskala „körperliche Funktionsfähigkeit” aus dem SF-36 im Vergleich (2001)

Pretesting of a questionnaire for evaluating day-patient rehabilitation, which included comparison of the "Hannover Functional Ability Questionnaire" (FFbH) and the SF-36 subscale "physical functioning" (SF-36 PF), gave rise to more extensive validity testing of the two instruments. In the framework of an expanded pretest, a questionnaire including FFbH and SF-36 PF was sent out to 520 adult former patients who had undergone inpatient orthopaedic rehabilitation following total hip or knee replacement an average 16 months ago. Return rate was 76%. Checks on plausibility showed no complaints about the Hannover Functional Ability Questionnaire while, on the SF-36 subscale, it was found that 16 of 374 patients (4.3%) had confused positive and negative ratings. Moreover, problems were found concerning the wording of several items (understanding, multidimensionality). In contrast to the FFbH, the SF-36 subscale shows weaknesses in the formulation of its items and particularly its ratings.
A distinct role for secreted fibroblast growth factor-binding proteins in development (2009)

FGFs modulate diverse biological processes including embryonic development. Secreted FGF-binding proteins (BPs) can release FGFs from their local extracellular matrix storage, chaperone them to their cognate receptors, and thus modulate FGF signaling. Here we describe 2 chicken BP homologs (chBP) that show distinct expression peaks at embryonic days E7.5 (chBP2) and E11.5 (chBP1), although their tissue distribution is similar (skin = intestine>lung>heart, liver). Embryos were grown ex ovo to monitor the phenotypic impact of a timed in vivo knockdown of expression peaks by microinjection of specific siRNAs targeted to either of the chBPs. Knockdown of peak expression of chBP2 caused embryonic lethality within <5 days. Surviving embryos showed defective ventral wall closure indicative of altered dorsoventral patterning. This defect coincided with reduced expression of HoxB7 but not HoxB8 that are involved in the control of thoracic/abdominal segment morphology. Also, MAPK phosphatase 3, a negative regulator of FGF signaling, and sonic hedgehog that can participate in feedback control of the FGF pathway were reduced, reflecting altered FGF signaling. Knockdown of the chBP1 expression peak caused embryonic lethality within <3 days although no distinct morphologic phenotype or pathways alterations were apparent. We conclude that BPs play a significant role in fine-tuning the complex FGF signaling network during distinct phases of embryonic development.
Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA (2001)

The interaction of the multimodular heterogeneous nuclear ribonucleoprotein (hnRNP) K protein with many of its protein and nucleic acid partners is regulated by extracellular signals. Acting as a docking platform, K protein could link signal-transduction pathways to DNA- and RNA-directed processes such as transcription, mRNA processing, transport, and translation. Treatment of hepatocyte culture with insulin increased K protein tyrosine phosphorylation. Insulin altered K protein interaction with RNA and DNA in vitro. Administration of insulin into mice had similar effects on K protein in liver. Coimmunoprecipitations of RNA with K protein revealed preferential in vivo K protein binding of a subset of transcripts, including the insulin-inducible c-fos mRNA. These results suggest a class of insulin pathways that signal nucleic acid-directed processes that involve K protein.
Photostability of Lycopene Dispersed in an Aqueous Solution (2011)

Lycopene dispersed in aqueous solutions with different dissolved oxygen contents was photo-irradiated by using a xenon weather meter, and the contents of lycopene and dissolved oxygen were measured. Both the degradation of lycopene and the consumption of dissolved oxygen followed a first-order kinetics model. There was a proportional relationship between the degradation content of lycopene and the consumption of dissolved oxygen. These results indicate that dissolved oxygen would also be involved in the photolysis of lycopene.
Identification, characterization, and DNA sequence of a functional "double" groES-like chaperonin from chloroplasts of higher plants. (1992)

Chloroplasts of higher plants contain a nuclear-encoded protein that is a functional homolog of the Escherichia coli chaperonin 10 (cpn10; also known as groES). In pea (Pisum sativum), chloroplast cpn10 was identified by its ability to (i) assist bacterial chaperonin 60 (cpn60; also known as groEL) in the ATP-dependent refolding of chemically denatured ribulose-1,5-bisphosphate carboxylase and (ii) form a stable complex with bacterial cpn60 in the presence of Mg.ATP. The subunit size of the pea protein is approximately 24 kDa--about twice the size of bacterial cpn10. A cDNA encoding a spinach (Spinacea oleracea) chloroplast cpn10 was isolated, sequenced, and expressed in vitro. The spinach protein is synthesized as a higher molecular mass precursor and has a typical chloroplast transit peptide. Surprisingly, however, attached to the transit peptide is a single protein, comprised of two distinct cpn10 molecules in tandem. Moreover, both halves of this "double" cpn10 are highly conserved at a number of residues that are present in all cpn10s that have been examined. Upon import into chloroplasts the spinach cpn10 precursor is processed to its mature form of approximately 24 kDa. N-terminal amino acid sequence analysis reveals that the mature pea and spinach cpn10 are identical at 13 of 21 residues.
Regulatory Sequences in the 3′ Untranslated Region of the Human cGMP-Phosphodiesterase β-Subunit Gene (2009)

These studies indicate that the 3' UTR of the PDEbeta mRNA is involved in the complex regulation of this gene's expression in the retina. Moreover, the results show that the PDEbeta poly-A signal has a dominant inhibitory effect over two other regions in the 3' UTR that stimulate gene expression.
Diversified copper sulfide (Cu<sub>2−x</sub>S) micro-/nanostructures: a comprehensive review on synthesis, modifications and applications (2017)

As a significant metal chalcogenide, copper sulfide (Cu<sub>2-x</sub>S, 0 < x < 1), with a unique semiconducting and nontoxic nature, has received significant attention over the past few decades. Extensive investigations have been employed to the various Cu<sub>2-x</sub>S micro-/nanostructures owing to their excellent optoelectronic behavior, potential thermoelectric properties, and promising biomedical applications. As a result, micro-/nanostructured Cu<sub>2-x</sub>S with well-controlled morphologies, sizes, crystalline phases, and compositions have been rationally synthesized and applied in the fields of photocatalysis, energy conversion, in vitro biosensing, and in vivo imaging and therapy. However, a comprehensive review on diversified Cu<sub>2-x</sub>S micro-/nanostructures is still lacking; therefore, there is an imperative need to thoroughly highlight the new advances made in function-directed Cu<sub>2-x</sub>S-based nanocomposites. In this review, we have summarized the important progress made in the diversified Cu<sub>2-x</sub>S micro-/nanostructures, including that in the synthetic strategies for the preparation of 0D, 1D, 2D, and 3D micro-/nanostructures (including polyhedral, hierarchical, hollow architectures, and superlattices) and in the development of modified Cu<sub>2-x</sub>S-based composites for enhanced performance, as well as their various applications. Furthermore, the present issues and promising research directions are briefly discussed.
Revisiting Uncertain Investment and Financing Decisions using Entry Probability (2013)

This paper extends the work of Chen and Chang (2010) and attempts to present a model for the optimal investment threshold and the real option value under price uncertainty from a different aspect of entry probability. I measure a financing policy by the debt ratio, a weight for the proportion of funding by debt relative to funding by equity. The weight is exogenously embedded in the stochastic optimization of an investment opportunity under price uncertainty. An entry probability, indicating the likelihood of an investment action optimally taken at a future time instant, is derived. Sensitivity analyses are performed to investigate the effects of parameters such as price volatility and price drift. The results demonstrate that price drift and price volatility might have different effects, depending on the time elapsed and on the debt ratio. In general, higher debt ratio contributes to higher investment threshold and higher real option value, confirming that financial leverage might serve as a value driver. However, as the debt ratio increases, the investment threshold might become too high to reach, indicating that waiting is the best choice. Such a circumstance is also verified by the entry probability approaching zero, which implies the far-reaching investment threshold.
Localization of an Effective Fibrin β-Chain Polymerization Site:  Implications for the Polymerization Mechanism (1997)

To examine whether fibrin N-terminal Aalpha 17-23 and Bbeta 15-25 may contain high-affinity polymerization sites, GPRVVER and GHRPLDKKREE analogs were prepared, and their abilities to inhibit fibrin monomers from repolymerizing were compared in turbidity and clottability assays. Within Aalpha 17-23, GPR is the most active site (IC30 of 0.95-1.36 mM). Its extension into GPRVVER (IC30 of 1.75-2.3 mM) reduced activity. Within Bbeta 15-25, acyl-DKKREE (IC30 of 0.30-0.53 mM) can account for GHRPLDKKREE activity (IC30 of 0. 33-0.44 mM). Comparison of the assays showed that calcium, whose presence induces thick fibrin fibers, elicited a higher turbidity than clottability inhibition. Similarly, the lateral-association-promoting GHRP (IC30 of 1.25-1.43 mM) gave a high turbidity vs clottability inhibition ratio (137%). In contrast, low ratios were found for the linear-association-initiating GPR (73%) and for acyl-DKKREE (34%). Structure-activity correlation showed that fibrinogen-like acyl-GPRP and acyl-GHRP could inhibit D. E association at the millimolar range, but in a manner different from fibrin-related GPR peptides did, which required the NH2 as well as Arg presence. To explain Bbeta 20-25 masking, it is proposed that DKKREE in fibrinogen may engage in ionic and hydrogen bonds with KDSDW, the Aalpha 29-33 sequence implicated in thrombin binding. To explain acyl-GPRP and acyl-GHRP inhibition of D.E association, it is proposed that fibrinogen packing may be mediated by E domain association with alphaC (Aalpha 220-609) fragments of adjacent molecules, and by alphaC-alphaC association. A modified polymerization mechanism is deduced by taking into account fibrinogen N-terminal conformation as well as E domain binding to thrombin vs alphaC fragments. This model proposes the following. (1) Upon thrombin binding to fibrinogen KDSDW, DKKREE may become exposed. (2) Fibrinopeptide A cleavage further unmasks the NH2 and Arg group of GPR, leading to DKKREE and GPR initiation of polymerization. (3) The micromolar-effective thrombin-fibrin(ogen) binding may initiate a partial alphaC repulsion. Subsequent DKKREE and GPR binding to D domains of other fibrin(ogen) will lead to the formation of the trimer and bring additional molecules to fibrin N-terminal region, and the combined steric congestion may lead to a complete alphaC repulsion from the overcrowded E domain. (4) Repulsion of the large Aalpha 220-609 fragments may unmask multiple polymerization sites beyond the fibrin N-terminal region.
Localization of the calmodulin- and the actin-binding sites of caldesmon (1991)

Expression of the C-terminal third of chicken gizzard caldesmon in Escherichia coli, using the Nagai vector (Nagai, K., and Thøgersen, H.V. (1987) Methods Enzmol. 153, 461-481), produces a cII-caldesmon fusion protein (27 kDa) with caldesmon sequence beginning at Lys579. Degradation during purification yields five peptides with molecular masses of 24, 22, 19 (two peptides), and 15 kDa. The 24-kDa peptide begins at Phe581; the 22-kDa peptide begins at Leu597, the two 19-kDa peptides begin at Phe581 and Val629, respectively; the 15-kDa peptide also begins at Val629. We estimate that the 15-kDa and one of the 19-kDa peptides end near Leu710. Site-directed mutagenesis was used to produce truncated peptides with known C termini; one peptide (17 kDa) terminates at Asn675. Digestion of the fragments with chymotrypsin generates a second 15-kDa fragment that begins at Ser666 (15K'). All of the peptides, with the exception of 15K', bind Ca(2+)-calmodulin-Sepharose and share a common 37-amino acid peptide between Val629 and Ser666, suggesting this contains the calmodulin binding site. Comparison with published sequences (Takagi, T., Yazawa, M., Ueno, T., Suzuki, S., and Yagi, K. (1989) J. Biochem. (Tokyo) 106, 778-783 and Bartegi, A., Fattoum, A., Derancourt, J., and Kassab, R. (1990) J. Biol. Chem. 265, 15231-15238) for other calmodulin-binding fragments further restricts the binding site to 7 residues, Trp-Glu-Lys-Gly-Asn-Val-Phe, between Trp659 and Ser666. All of the fragments, except the two 15-kDa peptides, co-sediment with F-actin, indicating that there are two segments in the C-terminal third of caldesmon that can interact with F-actin: one between Leu597 and Val629, the other between Arg711 and Pro756. Although separated in the primary sequence, these domains may interact with the calmodulin-binding region in the folded structure.
Who is behind the wheel? Driver identification and fingerprinting (2018)

In the last decade, significant advances have been made in sensing and communication technologies. Such progress led to a considerable growth in the development and use of intelligent transportation systems. Characterizing driving styles of drivers using in-vehicle sensor data is an interesting research problem and an essential real-world requirement for automotive industries. A good representation of driving features can be extremely valuable for anti-theft, auto insurance, autonomous driving, and many other application scenarios. This paper addresses the problem of driver identification using real driving datasets consisting of measurements taken from in-vehicle sensors. The paper investigates the minimum learning and classification times that are required to achieve a desired identification performance. Further, feature selection is carried out to extract the most relevant features for driver identification. Finally, in addition to driving pattern related features, driver related features (e.g., heart-rate) are shown to further improve the identification performance.
Decreased ARID1A expression is correlated with chemoresistance in epithelial ovarian cancer (2014)

The result suggests that decreased ARID1A expression is correlated with chemoresistance and may be a predictive factor for the risk of relapse of advanced cancer after achieving CR.
Regulation of sod genes in Escherichia coli: relevance to superoxide dismutase function (1991)

This review is concerned with the effects of environmental perturbations on the expression of the two superoxide dismutase (SOD) genes in Escherichia coli (sodA, MnSOD; sodB, FeSOD). Early studies using SOD activity, showed that MnSOD levels respond to changes in oxygen tension, type of substrate, redox active compounds, iron concentration, the nature of the terminal oxidant, and the redox potential of the medium. FeSOD levels appeared nominally insensitive to these perturbations. More recent molecular genetic studies revealed that sodA expression is subject to regulation by three major regulatory systems: fur (ferric uptake regulation) and arcA arcB (aerobic respiratory control) mediate repression of sodA, while a relatively new system, soxR soxS (superoxide response), mediates activation of sodA expression. By contrast, sodB expression, which is much less studied at this time, appears to be positively activated in trans by fur. A rudimentary gene regulation model is presented which rationalizes past observations, is experimentally testable, and should serve as a guide to future research in this area.