gebhart/patrepeval huggingface dataset:
The possible mechanisms by which phanoside stimulates insulin secretion from rat islets (2007)

We recently showed that phanoside, a gypenoside isolated from the plant Gynostemma pentaphyllum, stimulates insulin secretion from rat pancreatic islets. To study the mechanisms by which phanoside stimulates insulin secretion. Isolated pancreatic islets of normal Wistar (W) rats and spontaneously diabetic Goto-Kakizaki (GK) rats were batch incubated or perifused. At both 3 x 3 and 16 x 7 mM glucose, phanoside stimulated insulin secretion several fold in both W and diabetic GK rat islets. In perifusion of W islets, phanoside (75 and 150 microM) dose dependently increased insulin secretion that returned to basal levels when phanoside was omitted. When W rat islets were incubated at 3 x 3 mM glucose with 150 muM phanoside and 0 x 25 mM diazoxide to keep K-ATP channels open, insulin secretion was similar to that in islets incubated in 150 microM phanoside alone. At 16 x 7 mM glucose, phanoside-stimulated insulin secretion was reduced in the presence of 0 x 25 mM diazoxide (P<0 x 01). In W islets depolarized by 50 mM KCl and with diazoxide, phanoside stimulated insulin release twofold at 3 x 3 mM glucose but did not further increase the release at 16 x 7 mM glucose. When using nimodipine to block L-type Ca2+ channels in B-cells, phanoside-induced insulin secretion was unaffected at 3 x 3 mM glucose but decreased at 16 x 7 mM glucose (P<0 x 01). Pretreatment of islets with pertussis toxin to inhibit exocytotic Ge-protein did not affect insulin response to 150 microM phanoside. Phanoside stimulated insulin secretion from Wand GK rat islets. This effect seems to be exerted distal to K-ATP channels and L-type Ca2+ channels, which is on the exocytotic machinery of the B-cells.
Applications of Nano-Composite Piezoelectric Foam Sensors (2013)

This study develops highly flexible, adaptable, portable gauges that give real-time measurements in many applications where compression is of interest. They can be embedded into elastomeric foams, and preserve the desirable physical properties of the foams in dispersing impact energy. We anticipate that these novel and inexpensive sensors will enable real-time measurement of human impacts and athletic performance based on data collected in the field, rather than the current standard of trying to replicate these experiences in the lab. In previous work, we have validated the performance of tensile strain sensors based on a similar technology embedded in thin sheets of silicone. These sensors are capable of measuring up to 50% strains in real time with minimal interference in tissue motion. With the addition of the sensors described in the present work, it is possible to measure both tensile and compressive strains.
Improved algorithms for phase prediction and frame interpolation in low bit rate sinusoidal coders (2002)

A number of improved algorithms for phase prediction and frame interpolation in the context of sinusoidal speech coding are presented. A minimum variance sinusoidal phase estimation scheme is proposed, where it is shown that reasonably accurate estimates for short-time sinusoidal phases corresponding to voiced frames are obtained. On the other hand, improved algorithms for interpolation of sine wave parameters are presented which result in further reduction in bit rate while preserving the subjective quality of the reproduced speech at low bit rates. The performance of the above algorithms was evaluated on a large speech database and the results of statistical analysis are provided. The proposed algorithms were successfully integrated into a 2.4 kbps sinusoidal coder, where speech of good quality, intelligibility, and naturalness has been obtained.
Synthesis and the physical properties of MnZn ferrite and NiMnZn ferrite–polyaniline nanocomposite particles (2005)

We present a novel approach to synthesize MnZnferrite (MZF)–NiMnZnferrite(NiMZF)–Polyaniline (PANI) particles, where MnZnferrite is the magnetic core, and PANI is the conducting layer. The commercial ferrite and Ni–ferrite particles are primarily used, and the PANI–ferrite particles with a hybrid structure are synthesized via an oxidative electrochemical polymerization of aniline in an aqueous solution, which contains well-dispersed ferrite particles. The influence of ferrite content with respect to the electrical and ferromagnetic properties of the composite has been investigated by Electrochemical Impedance Spectroscopy (EIS) and DC field-cooled, zero-field cooled susceptibilities and M–H loop measurements. The origin of their electrical and ferromagnetic properties is also discussed based on structural characterizations including Fourier Transform Infrared (FT-IR) spectroscopy and X-Ray Diffraction (XRD).
Challenges in Collaborative Game Design Developing Learning Environments for Creating Games (2005)

We perform a general analysis of the game design process, the structure of digital games and investigate the requirements for the use of OpenCroquet as a platform for collaborative game design. Based on our experiences of using a Squeak/Tweak programming environment in many game projects and recently for teaching game design we derive properties of a learning environment for teaching game design in an OpenCroquet environment with a special focus on collaboration.
A PC-based general purpose Reed-Solomon codec simulator (1994)

This paper introduces a PC based general purpose Reed-Solomon (RS) codec simulator for teaching as well as research purposes. The user can define a code by selecting the symbol length 3/spl les/m/spl les/8 bits and the error correcting capability T of up to 20. In the encoder, the systematic code generation and the self-reciprocal generator polynomial are used. The error pattern can either be entered by the user with the arbitrary weight or generated by an external program which alternates all possible error positions. In the decoding process, both Peterson's and Berlekamp's algorithms are available for the user's choice. Chien Search is used for finding the error locations. The error values can be obtained by using either Gauss elimination or Forney's algorithm depending on the user's selection. The simulator has break points and printing-out at every step in encoding, error generating and decoding processes. The simulation software runs in MS Windows operating systems and provides a friendly and easy-to-use graphical interface (GUI). This is an ideal simulator for demonstrating the RS code encoding and decoding principle in classrooms and laboratories.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Intron retention is a source of neoepitopes in cancer (2018)

We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on the surface of cancer cell lines. RNA-derived neoepitopes should be considered for prospective personalized cancer vaccine development.
Leveraging energy storage to optimize data center electricity cost in emerging power markets (2016)

Energy storage in data centers has mainly been used as devices to backup generators during power outages. Recently, there has been a growing interest in using energy storage devices to actively shape power consumption in data centers to reduce their skyrocketing electricity bills. In this paper, we consider using energy storage in data centers for two applications in a joint fashion: reducing peak demand charges and enabling data centers to participate in regulation markets. We develop an optimization framework that captures the cost of electricity, degradation of energy storage devices, as well as the benefit from regulation markets. Under this frame- work, using real data Microsoft data center traces and PJM regulation signals, we show the electricity bill of a data center can be reduced by up to 20%. Furthermore, we demonstrate that the saving from joint optimization can be even larger than the sum of individually optimizing each component. We quantify the particular aspects of data center load profiles that lead to this superlinear gain. Compared to prior works that consider using energy storage devices for each single application alone, our results suggest that energy storage in data centers can have much larger impacts than previously thought possible.
Tensor-based Subspace Factorization for StyleGAN (2021)

In this paper, we propose TGAN a tensor-based method for modeling the latent space of generative models. The objective is to identify semantic directions in latent space. To this end, we propose to fit a multilinear tensor model on a structured facial expression database, which is initially embedded into latent space. We validate our approach on StyleGAN trained on FFHQ using BU-3DFE as a structured facial expression database. We show how the parameters of the multilinear tensor model can be approximated by Alternating Least Squares. Further, we introduce a stacked style-separated tensor model, defined as an ensemble of style-specific models to integrate our approach with the extended latent space of StyleGAN. We show that taking the individual styles of the extended latent space into account leads to higher model flexibility and lower reconstruction error. Finally, we do several experiments comparing our approach to former work on both GANs and multilinear models. Concretely, we analyze the expression subspace and find that the expression trajectories meet at an apathetic face that is consistent with earlier work. We also show that by changing the pose of a person, the generated image from our approach is closer to the ground truth than results from two competing approaches.
THE CHEMISTRY OF PHOSPHINIMINES (1981)

Abstract The synthesis, reactions and physical properties of phosphinimines and some related species are reviewed. Particular emphasis is placed upon recent developments in the field including their organometallic and coordination chemistry.
Targeting Residential Energy Assistance (2007)

This paper describes a four-step method to analyze the utility bills and weather data from multiple residences to target buildings for specific energy conservation retrofits. The method is also useful for focusing energy assessments on the most promising opportunities. The first step of the method is to create a three-parameter changepoint regression model of energy use versus weather for each building and fuel type. The three model parameters represent weather independent energy use, the building heating or cooling coefficient and the building balance-point temperature. The second step is to drive the models using typical TMY2 weather data to determine Normalized Annual Consumption (NAC) for each fuel type. The third step is to create a sliding NAC with each set of 12 sequential months of utility data. The final step is to benchmark the NACs and coefficients of multiple buildings to identify average, best and worst energy performers, and how the performance of each building has changed over time. The method identifies billing errors, normalizes energy use for changing weather, prioritizes sites for specific energy-efficiency retrofits and tracks weather-normalized changes in energy use. The principle differences between this method and previously defined ones are that this method seeks to use inverse modeling proactively to identify energy saving opportunities rather than retroactively to measure energy savings, it tracks changes in building performance using sliding analysis, and it uses comparisons between multiple buildings to extract additional information. This paper describes the method, then demonstrates the method through a case study of about 300 low-income residences. After applying the method, targeted buildings were visited to determine the accuracy of the method at identifying energy efficiency opportunities. The case study shows that over 80% of the targeted buildings presented at least one of the expected problems from each type of retrofit.
Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes (1996)

The large variability between individuals in the observed blood pressure response to these agents cannot be attributed to the polymorphisms analysed at the ACE and AGT loci.
A helicopter-borne eight-channel ranging scatterometer for remote sensing. II. Forest inventory (1993)

For pt.I see ibid., vol.31, no.1, p.161-9 (1993). Forest inventory methods based on data acquired with an airborne ranging radar are discussed. The approach can be used to partly automate present labor-dominated forest inventory methods. Using these methods, the mean and dominant tree height can be measured with a standard deviation of 1 m. The stem volume per hectare can be estimated with a relative accuracy of 15% by effectively counting the height distribution of the trees and by calculating the center of backscattered power from the forest canopy profile for a stand with a diameter of 40 m. The methods have been developed using a helicopter-borne eight-channel ranging scatterometer, HUTSCAT, which can measure a radar forest canopy profile with a range resolution of 65 cm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Increase in the synthesis of a Mr 32,000 protein in BALB/c 3T3 cells after treatment with tumor promoters, chemical carcinogens, metal salts, and heat shock. (1986)

The synthesis of a Mr 32,000 protein (p32) is enhanced as early as 2 h after the addition of tumor-promoting phorbol esters to BALB/c 3T3 cells. Among various compounds tested thus far, methyl methanesulfonate, N-methyl-N'-nitro-N-nitrosoguanidine, L-ascorbic acid, sodium deoxycholate, p-tosyl-L-phenylalanine chloromethyl ketone, p-tosyl-L-lysine chloromethyl ketone, 3,3'-diaminobenzidine, and some of the metal salts stimulated the synthesis of p32 to varying extents. p32 might be one of the heat shock proteins because its synthesis was also stimulated by heat shock or sodium arsenite. The synergisms of the effects of different compounds on p32 synthesis suggest that the expression of a p32 gene is regulated through at least three pathways. Possible roles of protein kinases in p32 gene expression are discussed.
Analysis and improvement of TCP performance in mobile ad hoc networks (2004)

An improved selective acknowledge algorithm is proposed to replace cumulative acknowledge algorithm to solve the "gap" problem in TCP receiver's window caused by high packet loss rate and link re-establishment of mobile ad hoc networks. TCP throughput performance of different TCP variants are compared and analyzed in details by simulations both under static chain topology and under dynamic network topology of mobile ad hoc networks. Simulations also show that the improved algorithm can improve TCP performance in mobile ad hoc networks considerably and leave more reservation space of TCP option for future use.
Chemokine Networks and Breast Cancer Metastasis (2007)

Chemokines have been initially characterized as chemoattractants for leukocytes infiltrating into inflamed tissues. However, over the past few years, accumulating evidence has described the critical involvement of this superfamily of intercellular signaling proteins in a variety of biological processes, which include embryogenesis, organogenesis, and tissue homeostasis. Moreover, recent work has demonstrated novel roles for chemokines and their receptors in regulating various aspects of the transformed phenotype, such as tumor growth, angiogenesis, invasion, and metastasis. Here, we review the current knowledge regarding chemokine/chemokine receptor involvement in breast cancer pathogenesis with primary emphases on their role in the metastatic spread of cancer cells and in tumor-stroma interactions.
Variation-Tolerant Quick-Start-Up CMOS Crystal Oscillator With Chirp Injection and Negative Resistance Booster (2015)

This paper presents a variation-tolerant quick-startup 39.25 MHz crystal oscillator and a theoretical analysis of a proposed chirp injector (CI) and negative resistance booster (NRB) for the quick start up. A new analysis of the theoretical minimum start-up time provides a new criterion for evaluating the start-up time in crystal oscillators. The calculated theoretical minimum start-up time at 39.25 MHz is 11.1 μs. Anew analysis of the proposed CI and NRB clarifies the validity of the universal optimum control method. It explains the reason why the proposed CI and NRB reduce the start-up time and its variation. The proposed crystal oscillator with the proposed CI and NRB exhibits a startup time of 158 μs at 39.25 MHz. The variation of the start-up time variations is ±13% over the supply voltage range of 1.2-1.8 V and ±7% over the temperature range of -30 to 125 °C. The power consumption of the crystal oscillator in the steady state is 181 μW with a phase noise of -147 dBc/Hz at 1 kHz offset frequency, which corresponds to a figure of merit (FoM) of 276 dB.
Nanopriming technology for enhancing germination and starch metabolism of aged rice seeds using phytosynthesized silver nanoparticles (2017)

Application of nanomaterials for agriculture is relatively new as compared to their use in biomedical and industrial sectors. In order to promote sustainable nanoagriculture, biocompatible silver nanoparticles (AgNPs) have been synthesized through green route using kaffir lime leaf extract for use as nanopriming agent for enhancing seed germination of rice aged seeds. Results of various characterization techniques showed the successful formation of AgNPs which were capped with phytochemicals present in the plant extract. Rice aged seeds primed with phytosynthesized AgNPs at 5 and 10 ppm significantly improved germination performance and seedling vigor compared to unprimed control, AgNO<sub>3</sub> priming, and conventional hydropriming. Nanopriming could enhance α-amylase activity, resulting in higher soluble sugar content for supporting seedlings growth. Furthermore, nanopriming stimulated the up-regulation of aquaporin genes in germinating seeds. Meanwhile, more ROS production was observed in germinating seeds of nanopriming treatment compared to unprimed control and other priming treatments, suggesting that both ROS and aquaporins play important roles in enhancing seed germination. Different mechanisms underlying nanopriming-induced seed germination were proposed, including creation of nanopores for enhanced water uptake, rebooting ROS/antioxidant systems in seeds, generation of hydroxyl radicals for cell wall loosening, and nanocatalyst for fastening starch hydrolysis.
Global temporal registration of multiple non-rigid surface sequences (2011)

In this paper we consider the problem of aligning multiple non-rigid surface mesh sequences into a single temporally consistent representation of the shape and motion. A global alignment graph structure is introduced which uses shape similarity to identify frames for inter-sequence registration. Graph optimisation is performed to minimise the total non-rigid deformation required to register the input sequences into a common structure. The resulting global alignment ensures that all input sequences are resampled with a common mesh structure which preserves the shape and temporal correspondence. Results demonstrate temporally consistent representation of several public databases of mesh sequences for multiple people performing a variety of motions with loose clothing and hair.
Scarf Osteotomy in Treating Hallux Valgus: Clinical and Radiographical Outcome and Technical Notes (2014)

Introduction Scarf osteotomy can be a technically demanding procedure and early reports have shown high complication rates. Proponents, however, suggest that this type of osteotomy is versatile and allows for both translation and angulation correction of the hallux valgus (HV) deformity. The purpose of this study was to evaluate the clinical and radiological results of the scarf osteotomy procedure performed in our hospital. Materials and methods We retrospectively reviewed 31 feet in 25 patients with an average follow-up duration of 16 months (range: 6–30 months). Results On the latest follow up, 77% of the patients were satisfied with the result, with an average postoperative American Orthopaedic Foot and Ankle Society score of 88. The average improvement of HV angle was from 37.9° to 10.0°. The intermetatarsal angle improved from 16.0° to 8.0°. The average first metatarsal shortening was 0.3 mm. Neither delayed union nor osteonecrosis was observed. Conclusion Scarf osteotomy is a reliable procedure to achieve correction of HV deformity with good patient satisfaction.
Baseline High Sensitivity Cardiac Troponin I Level Below Limit of Quantitation Rules Out Acute Myocardial Infarction in the Emergency Department (2020)

The objective of our study was to determine the utility of a baseline high sensitivity cardiac troponin (hs-cTnI) value below the limit of quantitation to rule-out acute myocardial infarction (AMI) in patients presenting to the emergency department (ED) with any suspicious symptoms of a cardiac etiology. We enrolled subjects presenting to the ED with symptoms suspicious for AMI. Blood specimens were collected within 1 hour after a triage electrocardiogram. Cardiac troponin I was measured using the Beckman Coulter Access hs-cTnI assay. The diagnosis of AMI was adjudicated by 2 cardiologists using the Third Universal Definition of AMI and Roche Diagnostics Troponin T Generation 5 assay with all available clinical data at 30 days after presentation. A total of 567 subjects had all data required for data analyses. AMI was diagnosed in 46 (8.1%) patients. Two hundred thirty-two (40.9%) individuals had presentation hs-cTnI results <4.0 ng/L. None of the patients with baseline hs-cTnI <4.0 ng/L had an AMI, yielding a negative predictive value of 100.0% and a sensitivity of 100%, and a good prognosis (no AMIs or cardiac-related deaths at 30 days). In this single-center ED study, a baseline presenting novel hs-cTnI value of <4.0 ng/L effectively ruled out AMI in 40.9% of all patients presenting to the ED and having any symptoms suspicious for AMI. Importantly all patients, not only those with chest pain, and those having symptoms for any duration or those with end-stage renal disease requiring dialysis were included.
Method of controlling temperature of a thermoelectric generator in an exhaust system (2023)

A method of controlling the temperature of a thermoelectric generator (TEG) in an exhaust system of an engine is provided. The method includes determining the temperature of the heated side of the TEG, determining exhaust gas flow rate through the TEG, and determining the exhaust gas temperature through the TEG. A rate of change in temperature of the heated side of the TEG is predicted based on the determined temperature, the determined exhaust gas flow rate, and the determined exhaust gas temperature through the TEG. Using the predicted rate of change of temperature of the heated side, exhaust gas flow rate through the TEG is calculated that will result in a maximum temperature of the heated side of the TEG less than a predetermined critical temperature given the predicted rate of change in temperature of the heated side of the TEG. A corresponding apparatus is provided.