gebhart/patrepeval huggingface dataset:
The emergence of InAs/InAsSb type-II strained layer superlattice barrier infrared detectors (2019)

The InAs/InAsSb (Gallium-free) type-II strained-layer superlattice (T2SLS) is an adjustable band gap, broad-band III-V infrared detector material that has emerged in recent years as an alternative to the more established InAs/GaSb type-II superlattice. We have reported results on a mid-wavelength focal plane array (FPA) based on the InAs/InAsSb T2SLS unipolar barrier infrared detector architecture. Significantly, the FPA exhibits very good operating characteristics at 160 K, demonstrating a considerably operating temperature advantage over the MWIR market-leading InSb FPAs, while maintaining III-V semiconductor manufacturing robustness. In this article we summarize the development at the NASA Jet Propulsion Laboratory leading to the mid-wavelength InAs/InAsSb T2SLS infrared detectors, provide a brief look at the history of the development of the InAs/InAsSb T2SLS absorber, and survey the current status of InAs/InAsSb T2SLS detectors.
Isolation and Characterization of Alveolar Epithelial Type II Cells Derived from Mouse Embryonic Stem Cells (2013)

The use of embryonic stem cells (ESCs) to regenerate distal lung epithelia damaged by injuries or diseases requires development of safe and efficient methodologies that direct ESC differentiation into transplantable distal lung epithelial progenitors. Time-consuming culture procedure and low differentiation efficiency are major problems that are associated with conventional differentiation approaches via embryoid body formation. The use of a growth factor cocktail or a lung-specific cell-conditioned medium to enrich definitive endoderm for efficient differentiation of mouse ESCs (mESC) into alveolar epithelial progenitor type II cells (ATIICs) has been reported, but not yet successful for generating a homogenous population of ATIICs for tissue regeneration purpose, and it remains unclear whether or not those mESC-derived ATIICs possess normal biological functions. Here, we report a novel method using a genetically modified mESC line harboring an ATIIC-specific neomycin(R) transgene in Rosa 26 locus. We showed that ATIICs can be efficiently differentiated from mESCs as early as day 7 by culturing them directly on Matrigel-coated plates in DMEM containing 15% knockout serum replacement. With this culture condition, the genetically modified mESCs can be selectively differentiated into a homogenous population (>99%) of ATIICs. Importantly, the mESC-derived ATIICs (mESC-ATIICs) exhibited typical lamellar bodies and expressed surfactant protein A, B, and C as normal control ATIICs. When cultured with an air-liquid-interface culture system in Small Airway Epithelial Cell Growth Medium, the mESC-ATIICs can be induced to secrete surfactant proteins after being treated with dibutyryl cAMP+dexamethasone. These mESC-ATIICs can synthesize and secrete surfactant lipid in response to secretagogue, demonstrating active surfactant metabolism in mESC-ATIICs as that seen in normal control ATIICs. In addition, we demonstrated that the selected mESC-ATIICs can be maintained on Matrigel-coated plates for at least 4 days with robust proliferative capacity. When cultured in DMEM medium containing 10% FBS, mESC-ATIICs spontaneously differentiated into alveolar epithelial type I cells. Collectively, these data demonstrate that the genetically modified mESCs can be selectively differentiated into a homogenous population of functional ATIICs, providing a reliable cell source to explore their therapeutic potential in lung tissue regeneration.
Thin-type natural three-dimensional display with 72 directional images (2005)

High-density generation of directional images can provide natural 3D images. Directional images are orthographic projections of a 3D scene into specific directions. A number of directional images projected into different horizontal directions are simultaneously displayed into the corresponding horizontal directions with nearly parallel rays. When the number of directional images becomes large enough and the display angle pitch becomes small enough, rays from a 3D scene are virtually reconstructed. A slanted lenticular sheet technique is used to construct a thin-type natural 3D display which can generate high-density directional images. A slanted lenticular sheet is attached to a high-resolution LCD panel to construct a 2D array of 3D pixels. One 3D pixel consists of 3M x N color sub-pixels to generate M x N rays having different horizontal proceeding directions. The lenticular sheet is slanted so as to differentiate all horizontal distances from the same color sub-pixels to the axis of a lenticle in each 3D pixel. The LCD panel having the resolution of 3,840 x 2,400 is used to construct 320 x 400 3D pixels and each 3D pixel emits rays into 72 different horizontal directions with the horizontal angle pitch of 0.38° by setting M = 12 and N = 6. The slant angle was determined by considering the directivity of directional images.
Fiber-optic lattice filtering (1984)

Lattice structures have found an increasing number of applications in the signal-processing area during the past decade. These structures can be used as alternative forms to realize a given filter transfer function or to parametrize a signal model.1 Compared to other realization forms, lattice structures have some advantageous characteristics, such as straightforwardness of implementation, modularity, regularity, and good sensitivity properties, which are very attractive for filtering applications.
High-Power, Widely-Tunable, Continuous-Wave Polycrystalline Cr2+:ZnS Laser (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text I. S. Moskalev, V. V. Fedorov, and S. B. Mirov, "High-Power, Widely-Tunable, Continuous-Wave Polycrystalline Cr2+:ZnS Laser," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper CWA1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis (2016)

Mitochondria-targeted compounds are emerging as a new class of drugs that can potentially alter the pathophysiology of those diseases where mitochondrial dysfunction plays a critical role. We have synthesized a novel mitochondria-targeted esculetin (Mito-Esc) with an aim to investigate its effect during oxidative stress-induced endothelial cell death and angiotensin (Ang)-II-induced atherosclerosis in ApoE(-/-) mice. Mito-Esc but not natural esculetin treatment significantly inhibited H2O2- and Ang-II-induced cell death in human aortic endothelial cells by enhancing NO production via AMPK-mediated eNOS phosphorylation. While L-NAME (NOS inhibitor) significantly abrogated Mito-Esc-mediated protective effects, Compound c (inhibitor of AMPK) significantly decreased Mito-Esc-mediated increase in NO production. Notably, Mito-Esc promoted mitochondrial biogenesis by enhancing SIRT3 expression through AMPK activation; and restored H2O2-induced inhibition of mitochondrial respiration. siSIRT3 treatment not only completely reversed Mito-Esc-mediated mitochondrial biogenetic marker expressions but also caused endothelial cell death. Furthermore, Mito-Esc administration to ApoE(-/-) mice greatly alleviated Ang-II-induced atheromatous plaque formation, monocyte infiltration and serum pro-inflammatory cytokines levels. We conclude that Mito-Esc is preferentially taken up by the mitochondria and preserves endothelial cell survival during oxidative stress by modulating NO generation via AMPK. Also, Mito-Esc-induced SIRT3 plays a pivotal role in mediating mitochondrial biogenesis and perhaps contributes to its anti-atherogenic effects.
Induction of Parasite Growth-Inhibitory Antibodies by a Virosomal Formulation of a Peptidomimetic of Loop I from Domain III of <i>Plasmodium falciparum</i> Apical Membrane Antigen 1 (2003)

Apical membrane antigen 1 (AMA-1) of Plasmodium falciparum is a leading candidate antigen for inclusion in a malaria subunit vaccine. Its ectodomain can be divided into three subdomains, each with disulfide bond-stabilized structures. Since the majority of antibodies raised against the ectodomain appear to recognize strain-specific epitopes in domain I, we attempted to develop a vaccine formulation which directs the immune response to a region that contains more conserved epitopes. Here we demonstrate that a virosomal formulation of a peptide that mimics the semiconserved loop I of domain III elicits parasite growth-inhibitory antibodies. A synthetic peptide comprising residues 446 to 490 of AMA-1 (AMA-1(446-490)) was conjugated through the N terminus to a derivative of phosphatidylethanolamine and the phosphatidylethanolamine-peptide conjugate was incorporated into immunopotentiating reconstituted influenza virosomes as a human-compatible antigen delivery system. Both cyclized and linear versions of the peptide antigen elicited antibodies which specifically bound to parasite-expressed AMA-1 in Western blotting with parasite lysates as well as in immunofluorescence assays with blood stage parasites. All 11 peptidomimetic-specific monoclonal antibodies generated were cross-reactive with parasite-expressed AMA-1. Antigen binding assays with a library of overlapping cyclic peptides covering the target sequence revealed differences in the fine specificity of these monoclonal antibodies and provided evidence that at least some of them recognized discontinuous epitopes. The two immunodominant epitopes comprised the conserved linear sequences K(459)RIKLN(464) and D(467)DEGNKKII(475). A key feature of the synthetic vaccine formulation proposed here is the display of the peptide antigen in a native-like state on the surface of the virosome.
Development of New Thickening Agent for Silicone Fluids. (1993)

Cross-linked silicone polymer is effective as a thickening agent of dimethylpolysiloxane. This agent was composed of methylhydrogenpolysiloxane, methylvinylpolysiloxane and dimethylpolysiloxane with platinum catalyst. This agent has some interesting properties as follows.(1) Low cross-linked density is necessary to get high thickness.(2) Effect of thickness is depending on the content of dimethylpolysiloxane.(3) This agent is more effective to low viscosity dimethylpolysiloxane.The uniform pasty silicone compound can be easily obtained by enoughly mixing this agent and another dimethylpolysiloxane as a main component with higher shearing force by the use of three-roll mixing mill. Silicone paste using this agent gives excellent properties as follows.(1) High transparency.(2) Excellent feeling and extendibility to skin without stickiness.(3) Long storage stability without oil separation.(4) Stable W/O emulsion can be easily obtained by using polyoxyalkylene-modified silicone fluid.
Dual LMCs fusion for recognition of isolated Arabic sign language words (2017)

In this paper, we propose a Dual-Leap Motion Controllers (DLMC) based Arabic Sign Language recognition system. More particularly, we propose to use both front and side controllers to cater for the challenges of finger occlusions and missing data. For feature extraction, we select an optimum set of geometric features extracted from both controllers, while for classification, we used both a Bayesian approach with a Gaussian Mixture Model (GMM) and a simple Linear Discriminant Analysis (LDA) approach. Though this paper focused only on the GMM approach. Data was collected from a native adult signer, for 100 isolated Arabic words. Ten observations were collected for each of the signs. The proposed framework uses an intelligent strategy to handle the case of missing data from one or both controllers. A recognition accuracy of 94.63% was achieved, with the proposed system. The proposed system outperforms glove-based systems and a single-LMC based techniques.
An Improved and Scalable Process for Celecoxib: A Selective Cyclooxygenase-2 Inhibitor (2008)

ADVERTISEMENT RETURN TO ISSUEPREVTechnical NoteNEXTAn Improved and Scalable Process for Celecoxib: A Selective Cyclooxygenase-2 Inhibitor§Anumula Raghupathi Reddy, Alla Sampath, Gilla Goverdhan, Bojja Yakambaram, Kagga Mukkanti‡, and Padi Pratap Reddy*View Author Information Department of Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy's Laboratories Ltd., Survey Nos. 42, 45, 46, and 54, Bachupally, Qutubullapur, R R Dist-500 072, A.P., India§Dr. Reddy's Communication no. IPDOIPM-00139.* To whom correspondence should be addressed. E-mail: [email protected]. Fax: 914044346285. Telephone: 9989997176.‡Institute of Science and Technology, Center for Environmental Science, J.N.T. University, Kukatpally, Hyderabad-500 072, A.P., India.Cite this: Org. Process Res. Dev. 2009, 13, 1, 98–101Publication Date (Web):November 26, 2008Publication History Received3 July 2008Published online26 November 2008Published inissue 16 January 2009https://pubs.acs.org/doi/10.1021/op800158whttps://doi.org/10.1021/op800158wbrief-reportACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views3951Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ethyl groups,Hydrocarbons,Mixtures,Organic compounds,Solvents Get e-Alerts
Wien-filter spin rotator with integrated ion pump (2023)

Nuclear physics experiments performed at the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Laboratory (JLab) require highly polarized electron beams, produced from strained super-lattice GaAs/GaAsP photocathodes. To prolong the photocathode operational lifetime, the photogun and adjoining beamline should be maintained at the lowest possible pressure. This document describes a Wien filter spin manipulator with Penning traps incorporated along the length of the high voltage electrodes. For some spin settings, the Wien filter acts as an ion pump. Although the Wien filters at CEBAF are relatively far from the photocathode, a Wien filter spin manipulator with distributed pumping could serve to improve photocathode operating lifetime.
Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms (2019)

Breast cancer is the most prevalent tumor in women worldwide and about 70% patients are estrogen receptor positive. In these cancer patients, resistance to the anticancer estrogen receptor antagonist tamoxifen emerges to be a major clinical obstacle. Peptidyl-prolyl isomerase Pin1 is prominently overexpressed in breast cancer and involves in tamoxifen-resistance. Here, we explore the mechanism and effect of targeting Pin1 using its chemical inhibitor all-trans retinoic acid (ATRA) in the treatment of tamoxifen-resistant breast cancer. We found that Pin1 was up-regulated in tamoxifen-resistant human breast cancer cell lines and tumor tissues from relapsed patients. Pin1 overexpression increased the phosphorylation of ERα on S118 and stabilized ERα protein. ATRA treatment, resembling the effect of Pin1 knockdown, promoted ERα degradation in tamoxifen-resistant cells. Moreover, ATRA or Pin1 knockdown decreased the activation of ERK1/2 and AKT pathways. ATRA also reduced the nuclear expression and transcriptional activity of ERα. Importantly, ATRA inhibited cell viability and proliferation of tamoxifen-resistant human breast cancer cells <i>in vitro</i>. Slow-releasing ATRA tablets reduced the growth of tamoxifen-resistant human breast cancer xenografts <i>in vivo</i>. In conclusion, ATRA-induced Pin1 ablation inhibits tamoxifen-resistant breast cancer growth by suppressing multifactorial mechanisms of tamoxifen resistance simultaneously, which demonstrates an attractive strategy for treating aggressive and endocrine-resistant tumors.
“Keyhole” method for accelerating imaging of contrast agent uptake (1993)

Magnetic resonance (MR) imaging methods with good spatial and contrast resolution are often too slow to follow the uptake of contrast agents with the desired temporal resolution. Imaging can be accelerated by skipping the acquisition of data normally taken with strong phase-encoding gradients, restricting acquisition to weak-gradient data only. If the usual procedure of substituting zeroes for the missing data is followed, blurring results. Substituting instead reference data taken before or well after contrast agent injection reduces this problem. Volunteer and patient images obtained by using such reference data show that imaging can be usefully accelerated severalfold. Cortical and medullary regions of interest and whole kidney regions were studied, and both gradient- and spin-echo images are shown. The method is believed to be compatible with other acceleration methods such as half-Fourier reconstruction and reading of more than one line of k space per excitation.
Parallel processing of multi-dimensional data with causal neighborhood dependencies (2007)

In this paper, we investigate the problem of enabling block level parallelism, for multi-dimensional data sets, with arbitrary but static causal dependency between blocks that constitute the data set. As the use of video and other multi-dimensional data sets becomes more common place and the algorithms used to process them become more complex, there is greater need for effective parallelization schemes. We describe a method for synchronizing the execution of multiple processors to respect the dependency structure and calculate the total processing time as a function of the number of parallel processors. We also provide an algorithm to calculate the optimal starting times for each processor which enables them to continuously process blocks without the need for synchronizing with other processors, under the assumption that the time to process each block is fixed.
Enhanced Split TCP with End-to-End Protocol Semantics over Wireless Networks (2017)

The global mobile traffic is exponentially growing and more than 90% of the Internet traffic uses Transmission Control Protocol (TCP) for reliable transmission. However, TCP is known to perform poorly over unreliable wireless networks. One of the promising families of solutions to improve the performance of TCP is centered on Split-TCP. However, while Split-TCP may improve the protocol performance, it is vulnerable due to the broken end-to-end semantics. Several variants have been proposed to overcome this pitfall, but while they address the broken semantics, they also defeat the main purpose by compromising the TCP performance gains. In this paper, we propose a novel Enhanced Split-TCP (ES-TCP) mechanism, which significantly improves the application throughput without breaking the end-to-end TCP semantics. Experimental results show that the proposed ES-TCP may boost the TCP throughput by more than 60% in average when exercised over an operational 4G LTE network. Furthermore, the TCP throughput performance improvement may be even over 200%, depending on the network and usage conditions. We expect such throughput gains may be even greater when advanced radio technologies, such as 5G, are deployed. For these reasons, the ES-TCP is a promising transport layer solution for the current and next generation networks.
Identification and fine‐mapping of <i>RppCML496</i> , a major QTL for resistance to <i>Puccinia polysora</i> in maize (2020)

Southern corn rust (SCR), which is caused by the fungal pathogen Puccinia polysora Underw, is a prevalent foliar disease in maize. Breeding for resistant cultivars is a desirable way for the efficient control of this disease. To identify quantitative trait loci (QTL) for conferring resistance to SCR, a recombinant inbred population including 138 lines (RILs) derived from the SCR-resistant line CML496 and susceptible line Lx9801 was evaluated for phenotypic reaction to SCR in three trials in two locations over 2 years. The population was genotyped with the maize 9.4K SNP Genotyping Array marker platform. A total of 3 QTL were mapped on chromosomes 6, 9 and 10, respectively. One major QTL on chromosome 10 (bin 10.00/10.01), RppCML496, was consistently detected across environments, which explained 43-78% of the total phenotypic variation. Using a fine mapping strategy, we delimited RppCML496 to an interval of 128 Kb. Genome mining of this region suggests two candidate genes, and a NBS-LRR gene is the promising one for RppCML496 against SCR. The tightly linked molecular markers developed in this study can be used for molecular breeding of resistance to SCR in maize.
Use of Sieved Compost Plus Hydrogel for Solid Matrix Priming of Carrot Seeds (2012)

In this study we report the water release curve of a compost-based carrier for solid matrix priming and its effects on carrot seed germination. ‘Danvers Half Long’ and ‘Nantes Scarlet’ carrot (Daucus carota) seeds were primed for 7 d at 15°C in a carrier consisting of 5:1:5.7 sieved compost: hydrogel:distilled water (based on weight) equaling a water potential of −1.0 MPa. Seeds were blended with carrier at 1:10, 1:20, 1:30, or 1:40 (based on weight) and compost priming was compared with a polyethylene glycol (PEG) priming procedure. Germination testing at 20-30°C (16-8 h) in darkness indicated that all compost priming treatments hastened seed germination more than PEG priming. Compost priming at 1:30 increased final germination percentage (FGP) for ‘Nantes Scarlet’ (FGP = 85%) compared to PEG primed (FGP = 72%) seeds but ‘Danvers Half Long’ FGP was similar for all treatments. For both cultivars, seeds that were compost primed had reduced G (days to 10% FGP) and G (days to 50% FGP) compared to PEG primed or nonprimed seed. For ‘Danvers Half Long’ carrot seeds, priming ratios of 1:30 reduced G values more effectively than all other treatments. For ‘Nantes Scarlet’ carrot seeds, G10 and G50 values were reduced similarly at all seed-to-carrier ratios. Compost primed seeds could be dried and stored for 35 d at 3 or 20-30°C (16-8 h) for ‘Danvers Half Long’ and for 35 d at 3°C for ‘Nantes Scarlet’ with no loss in priming benefit. We conclude that solid matrix priming with a compost based carrier is a satisfactory alternative to PEG priming to improve germination of carrot seed.