gebhart/patrepeval huggingface dataset:
Nonlinear Vibrations of Cantilever Beams and Plates (2003)

A study of the nonlinear vibrations of metallic cantilever beams and plates subjected to transverse harmonic excitations is presented. Both experimental and theoretical results are presented. The primary focus is however on the transfer of energy between widely spaced modes via modulation. This phenomenon is studied both in the presence and absence of a one-to-one internal resonance. Reduced-order models using Galerkin discretization are also developed to predict experimentally observed motions. A good qualitative agreement is obtained between the experimental and numerical results. Experimentally the energy transfer between widely spaced modes is found to be a function of the closeness of the modulation frequency to the natural frequency of the first mode. The modulation frequency, which depends on various parameters like the amplitude and frequency of excitation, damping factors, etc., has to be near the natural frequency of the low-frequency mode for significant transfer of energy from the directly excited high-frequency mode to the low-frequency mode. An experimental parametric identification technique is developed for estimating the linear and nonlinear damping coefficients and effective nonlinearity of a metallic cantilever beam. This method is applicable to any single-degree-of-freedom nonlinear system with weak cubic geometric and inertia nonlinearities. In addition, two methods, based on the elimination theory of polynomials, are proposed for determining both the critical forcing amplitude as well as the jump frequencies in the case of single-degree-of-freedom nonlinear systems. An experimental study of the response of a rectangular, aluminum cantilever plate to transverse harmonic excitations is also conducted. Various nonlinear dynamic phenomena, like two-to-one and three-to-one internal resonances, external combination resonance, energy transfer between widely spaced modes via modulation, period-doubled motions, and chaos, are demonstrated using a single plate. It is again shown that the closeness of the modulation frequency to the natural frequency of the first mode dictates the energy transfer between widely spaced modes.
A Comprehensive Review on Amyotrophic Lateral Sclerosis (2014)

Amyotrophic lateral sclerosis (ALS) – also referred to as motor neurone disease in some Commonwealth of Nations countries and as Lou Gehrig's disease in the United States – is a debilitating disease with varied etiology characterized by rapidly progressive weakness, muscle atrophy and fasciculations, muscle spasticity, difficulty speaking (dysarthria), difficulty swallowing (dysphagia), and difficulty breathing (dyspnea). ALS is the most common of the five motor neuron diseases1. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed. A-myo-trophic comes from the Greek language. A means no or negative. Myo refers to muscle, and Trophic means nourishment–No muscle nourishment. When a muscle has no nourishment, it atrophies or wastes away. Lateral identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located. As this area degenerates it leads to scarring or hardening (sclerosis) in the region. As motor neurons degenerate, they can no longer send impulses to the muscle fibers that normally result in muscle movement. Early symptoms of ALS often include increasing muscle weakness, especially involving the arms and legs, speech, swallowing or breathing. When muscles no longer receive the messages from the motor neurons that they require to function, the muscles begin to atrophy (become smaller). Limbs begin to look thinner as muscle tissue atrophies2.
A Study on the Relationship between Employment Structure and Tourist Demand in China (2008)

Based on the hypothesis of positive feedbacks model of employment structure and tourist demand,the relationship between the evolvement of employment structure and domestic tourist demand was analyzed using unit root test,cointegration test and Granger causality test and the statistics results of employment structure and domestic tourists from 1984 to 2006.The empirical results showed that a strong correlativity between the employment structure and the domestic tourists existed,and there were not only a long term cointegration,but also a law of positive and negative diminishing growth between them.At the same time,the evidence discovered that the decrease of the employment in the primal industry drove the increase of domestic tourists.
Optical-beam steering for fiber array using dynamic holography (1986)

A two-dimensional optooptical addressing system for fiber-array interconnections is described. The optical beam is deflected by a dynamic holographic grating. The characteristics of this grating are automatically adapted in a passive way to assure maximum efficiency during commutation process.
CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons <i>In vitro</i> and <i>In vivo</i> (2007)

CHIR-124 is a novel and potent Chk1 inhibitor with promising antitumor activities when used in combination with topoisomerase I poisons.
Utilizing Predictors for Efficient Thermal Management in Multiprocessor SoCs (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Conventional thermal management techniques are reactive, as they take action after temperature reaches a threshold. Such approaches do not always minimize and balance the temperature, and they control temperature at a noticeable performance cost. This paper investigates how to use predictors for forecasting temperature and workload dynamics, and proposes proactive thermal management techniques for multiprocessor system-on-chips. The predictors we study include autoregressive moving average modeling and lookup tables. We evaluate several reactive and predictive techniques on an UltraSPARC T1 processor and an architecture-level simulator. Proactive methods achieve significantly better thermal profiles and performance in comparison to reactive policies. </para>
Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival (2021)

Understanding how antibody responses to SARS-CoV-2 evolve during infection may provide important insight into therapeutic approaches and vaccination for COVID-19. Here we profile the antibody responses of 162 COVID-19 symptomatic patients in the COVID-BioB cohort followed longitudinally for up to eight months from symptom onset to find SARS-CoV-2 neutralization, as well as antibodies either recognizing SARS-CoV-2 spike antigens and nucleoprotein, or specific for S2 antigen of seasonal beta-coronaviruses and hemagglutinin of the H1N1 flu virus. The presence of neutralizing antibodies within the first weeks from symptoms onset correlates with time to a negative swab result (p = 0.002), while the lack of neutralizing capacity correlates with an increased risk of a fatal outcome (p = 0.008). Neutralizing antibody titers progressively drop after 5-8 weeks but are still detectable up to 8 months in the majority of recovered patients regardless of age or co-morbidities, with IgG to spike antigens providing the best correlate of neutralization. Antibody responses to seasonal coronaviruses are temporarily boosted, and parallel those to SARS-CoV-2 without dampening the specific response or worsening disease progression. Our results thus suggest compromised immune responses to the SARS-CoV-2 spike to be a major trait of COVID-19 patients with critical conditions, and thereby inform on the planning of COVID-19 patient care and therapy prioritization.
Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease (2013)

Exposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.
Action Extraction in Continuous Unconstrained Video for Cloud-Based Intelligent Service Robot (2018)

Transferring complex computing to the cloud server side leverages cloud-based intelligent service robots that are capable of highly complex computing tasks such as video analysis. In practical behavior surveillance applications, the captured videos from intelligent service robots are continuous. Action extraction from continuous unconstrained video is an important prerequisite for action analysis, such as action classification and recognition, abnormal event detection, and crowd emotion sensing. This paper proposes a novel approach for action extraction in continuous unconstrained video, which has three parts: spatial location estimation, temporal action path searching; and spatial-temporal action compensation. Spatial location estimation utilizes both human appearance and motion cues to obtain frame-level bounding boxes. Then, with the spatial action proposal results as a priori, the searching of temporal action paths is formulated as an optimal estimation problem by accounting for the missed detections and false alarms of the spatial location estimation. To solve the temporal action path searching problem, we propose the Markov Chain Monte Carlo algorithm and illustrate its convergence property. Extensive experiments on the challenging UCF-Sports and UCF-101 data sets show the effectiveness of our approach and obtain superior performance compared with the state-of-the-arts.
Counterfactual quantum-information transfer without transmitting any physical particles (2015)

We demonstrate quantum information can be transferred between two distant participants without any physical particles traveling between them. The key procedure of the counterfactual scheme is to entangle two nonlocal qubits with each other without interaction, so the scheme can also be used to generate nonlocal entanglement counterfactually. We here illustrate the scheme by using flying photon qubits and Rydberg atom qubits assisted by a mesoscopic atomic ensemble. Unlike the typical teleportation, the present scheme can transport an unknown qubit in a nondeterministic manner without prior entanglement sharing or classical communication between the two distant participants.
Phase I studies of continuous-infusion paclitaxel given with standard aggressive radiation therapy for locally advanced solid tumors. (1995)

Currently available therapies are unsatisfactory for locally advanced solid tumors of the lung, head and neck, and brain. Laboratory data suggest that the addition of paclitaxel (Taxol; Bristol-Myers Squibb Oncology, Princeton, NJ), a microtubule-stabilizing drug, to radiation therapy may result in significant radiation sensitization, perhaps because paclitaxel induces cell cycle arrest at G2/M. Relatively low concentrations, 1 to 10 nmol/L, appear to be optimal for direct cytotoxicity and radiosensitization in vitro. Within this dose range, more prolonged exposure seems to result in higher response rates. We are conducting phase I trials designed to test continuous infusion (24 hours per day, 7 days per week) intravenous paclitaxel combined with standard curative-intent radiation therapy. To date, 22 patients are evaluable, and the maximum tolerated dose of paclitaxel has not been reached at up to 2.5 mg/m2/d. Observed toxicities include anemia, lymphopenia, mucositis, and cutaneous erythema/desquamation.
Immunotherapy for Alzheimer's disease (2012)

Alzheimer's disease (AD) is characterized by β-amyloid (Aβ) plaques consisted primarily of aggregated Aβ proteins and neurofibrillary tangles formed by hyperphosphorylated tau protein. Both Aβ and hyperphosphorylated tau are toxic both in vivo and in vitro. Immunotherapy targeting Aβ seems to provide a promising approach to reduce the toxic species in the brain. However, there is little evidence from clinical trials so far indicating the efficacy of Aβ immunotherapy in cognitive improvement. Immunization with tau peptides or anti-tau antibodies could remove the tau aggregates and improve the cognitive function in preclinical study, which provides a novel strategy of AD therapy. In this article, we will summarize the immunotherapeutic strategies targeting either Aβ or tau.
Keep Cell Phones and PDAs Away From EMG Sensors and the Human Body to Prevent Electromagnetic Interference Artifacts and Cancer (2009)

Abstract Cell phones produce electromagnetic interference (EMI), which can cause artifacts in physiological recordings and be misinterpreted by the clinician. This study investigated the possible effect of EMI (electrical artifact) on physiological recordings when cell phones are activated/ringing. The procedure consisted of placing the cell phone at varying distances from surface electromyographic sensors. Depending on the orientation of the cell phone's antenna, the EMI produced an artifact in the physiological signal for up to 175 cm (6 ft) that can be misinterpreted by the therapist. To avoid EMI artifacts, clients and therapists should turn off their cell phones when recording physiological signals. This means turning the cell phone off and not just switching it to vibrate. In addition, recent epidemiological studies suggest that long-term intensive cell phone use may increase the risk of gliomas, auditory tumors, and salivary tumors on the side of the head to which the person places the cell phone. Thus, to reduce artifacts and biological harm, the authors recommend keeping the cell phone away from the body and the biofeedback equipment.
A statistical approach with HMMs for on-line cursive Hangul (Korean script) recognition (2002)

A statistical approach to recognizing on-line cursive Hangul character is proposed. Viewing a handwritten Hangul syllable as an alternating sequence of letters and ligatures, all handwritten legal characters are modeled with a finite state network that is a concatenation of letter and ligature HMMs. Given an input to the network, recognition, which corresponds to finding the most likely path, is performed using the dynamic programming technique. Experiments have shown that letter boundary detection as well as handwriting variability resolution is achieved with good results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Microvolume Blood-Sampling Device with Low Hemolysis and High Consistent Yield of Serum Components (2001)

The newly developed device allows recovery of 60% of serum components from microvolumes of blood by finger puncture with neither degradation of analytes at room temperature nor hemolysis.
Cost-effective allocation of radioports under constant offered load (2003)

Determining the most cost-effective allocation of resources in wireless network infrastructures is a difficult combinatorial problem when only the general case is considered. A significant class of wireless networks comprises those serving dense user populations with approximately uniform spatial distribution of offered load. In such networks, it is shown that analytical solutions for optimal radioport power and cost are feasible. Mathematical proof of the above is presented, as well as examples for different levels of offered load. It is also demonstrated that, for the cost model used, cost is not highly sensitive to quality of service.
Marketing Strategies for Europe 1992 (1993)

In this paper a portfolio model of marketing strategies is presented based on a study of consumer/product relationships in the EC with particular emphasis on reference group influence. First, supporting models and theories from the fields of consumer behavior and marketing are reviewed. Then the model is discussed in relation to applications in the European market. Finally, future perspectives for change in European consumer behavior and product preferences are addressed, along with implications for marketing strategy and further research.
Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine (2011)

"K2/SPICE" products are commonly laced with aminoalkylindole synthetic cannabinoids (i.e., JWH-018 and JWH-073) and are touted as "legal" marijuana substitutes. Here we validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring urinary concentrations of JWH-018, JWH-073, and several potential metabolites of each. The analytical procedure has high capacity for sample throughput and does not require solid phase or liquid extraction. Evaluation of human urine specimens collected after the subjects reportedly administered JWH-018 or a mixture of JWH-018 and JWH-073 provides preliminary evidence of clinical utility. Two subjects that consumed JWH-018 primarily excreted glucuronidated conjugates of 5-(3-(1-naphthoyl)-1H-indol-1-yl)-pentanoic acid (>30 ng/mL) and (1-(5-hydroxypentyl)-1H-indol-3-yl)(naphthalene-1-yl)-methanone (>50 ng/mL). Interestingly, oxidized metabolites of both JWH-018 and JWH-073 were detected in these specimens, suggesting either metabolic demethylation of JWH-018 to JWH-073 or a nonreported, previous JWH-073 exposure. Metabolic profiles generated from a subject who consumed a mixture of JWH-018 and JWH-073 were similar to profiles generated from subjects who presumably consumed JWH-018 exclusively. Oxidized metabolites of JWH-018 and JWH-073 were of the same pattern, but JWH-018 metabolites were excreted at lower concentrations. These results begin clinically validating the LC-MS/MS assay for detecting and quantifying aminoalkylindole metabolites. Full validation awaits further testing.
Hydroclassified Combinatorial Saturation Mutagenesis: Reshaping Substrate Binding Pockets of <i>Kp</i>ADH for Enantioselective Reduction of Bulky–Bulky Ketones (2018)

A hydroclassified combinatorial saturation mutagenesis (HCSM) strategy was proposed for reshaping the substrate binding pocket by dividing 20 amino acids into four groups based on their hydrophobicity and size. These smart HCSM libraries could significantly reduce screening effort especially for the simultaneous mutagenesis of three or more residues and lacking high throughput screening methods. Employing HCSM strategy, the stereoselectivity of KpADH, an alcohol dehydrogenase from Kluyveromyces polysporus, was efficiently improved to 99.4% ee. (4-Chlorophenyl)(pyridin-2-yl)methanone (CPMK), generally regarded as a “hard-to-reduce” ketone, was used as a model substrate, and its corresponding chiral alcohol products could be utilized as antihistamine precursors. The best variant 50C10 displayed higher binding affinity and catalytic efficiency toward CPMK with KM/kcat of 59.3 s–1·mM–1, 3.51-fold that of KpADH. Based on MD simulations, increased difference between two binding pockets, enhanced hydrophobicity, and π–π and halogen–alkyl interactions were proposed to favor the enantioselective recognition and substrate binding in 50C10. Substrate spectrum analysis revealed that 50C10 exhibited improved enantioselectivity toward diaryl ketones especially with halo- or other electron-withdrawing groups. As much as 500 mM CPMK could be asymmetrically reduced into chiral diaryl alcohols with ee of 99.4% and a space–time yield of 194 g·L–1·d–1 without addition of external NADP+. This study provides an effective mutagenesis strategy for the protein engineering of substrate specificity and enantioselectivity.
Toward the Restoration of Hand Use to a Paralyzed Monkey: Brain-Controlled Functional Electrical Stimulation of Forearm Muscles (2009)

Loss of hand use is considered by many spinal cord injury survivors to be the most devastating consequence of their injury. Functional electrical stimulation (FES) of forearm and hand muscles has been used to provide basic, voluntary hand grasp to hundreds of human patients. Current approaches typically grade pre-programmed patterns of muscle activation using simple control signals, such as those derived from residual movement or muscle activity. However, the use of such fixed stimulation patterns limits hand function to the few tasks programmed into the controller. In contrast, we are developing a system that uses neural signals recorded from a multi-electrode array implanted in the motor cortex; this system has the potential to provide independent control of multiple muscles over a broad range of functional tasks. Two monkeys were able to use this cortically controlled FES system to control the contraction of four forearm muscles despite temporary limb paralysis. The amount of wrist force the monkeys were able to produce in a one-dimensional force tracking task was significantly increased. Furthermore, the monkeys were able to control the magnitude and time course of the force with sufficient accuracy to track visually displayed force targets at speeds reduced by only one-third to one-half of normal. Although these results were achieved by controlling only four muscles, there is no fundamental reason why the same methods could not be scaled up to control a larger number of muscles. We believe these results provide an important proof of concept that brain-controlled FES prostheses could ultimately be of great benefit to paralyzed patients with injuries in the mid-cervical spinal cord.
Technical improvements in the immunoperoxidase study of renal biopsy specimens. (1990)

Sixty five renal biopsy specimens were used to compare a direct immunofluorescence technique on frozen sections with immunoperoxidase techniques on paraffin wax sections. For the immunoperoxidase techniques, dewaxed sections were treated with protease at 37 degrees C. Sections were examined at intervals on a microscope and digestion was stopped when plasma was removed from glomerular capillary loops. This permitted intense staining of immunoproteins on immunoperoxidase. There was agreement between immunoperoxidase and immunofluorescence in the staining for IgG, IgA, and IgM in 50 biopsy specimens and discordant findings did not affect the diagnosis. Immunoperoxidase did not detect C3 in 16 biopsy specimens. Findings with antiserum to another complement component, C9, detected by immunoperoxidase correlated with C3 findings detected by immunofluorescence in 17 biopsy specimens. It is concluded that microscopical observation of the progress of digestion permits optimal staining by immunoperoxidase methods, thus overcoming the problem of variability in proteolytic digestion of sections. Inconsistency in the demonstration of complement deposition can be avoided by staining for C9 rather than C3.
Association of B-Type Natriuretic Peptide Levels With Estimated Glomerular Filtration Rate and Congestive Heart Failure (2009)

BNP levels show a strong inverse association with eGFR in both CHF and non-CHF patients. Currently best practice at most institutions involves use of BNP cutoff diagnostic levels not adjusted for eGFR. The data presented underlines that eGFR is a significant confounder of BNP measurement especially when renal status is compromised and interpretation of clinical significance in the presence of elevated BNP measures should take renal status into consideration.