gebhart/patrepeval huggingface dataset:
Grasping without squeezing: Shear adhesion gripper with fibrillar thin film (2015)

Nearly all robotic grippers have one trait in common: they grasp objects with normal forces, either directly, or indirectly through friction. This method of grasping is effective for objects small enough for a given gripper to partially encompass. However, to grasp larger objects, significant grip forces and a high coefficient of friction are required. We present a new grasping method for convex objects, using almost exclusively shear forces. We achieve shear grasping with a gripper that utilizes thin film gecko-inspired fibrillar adhesives that conform to the curvature of the object. We present a verified model for grasping a range of curvatures and results that demonstrate the thin film fibrillar adhesives' increased contact area on textured surfaces when loaded in shear. Finally, the gripper is implemented on a robotic arm and grasps a variety of convex objects (at rest and ballistic).
New bismaleimide matrix resins for graphite fiber composites (1985)

Two new bismaleimide resins based on the N, N'-m-phenylene-bis(m-amino-benzamide) structure have been synthesized and characterized. The mixtures of the two resins gave better handling, processing, mechanical, and thermal properties in graphite composites than did the individual resins. The mechanical strength of the cured graphite composites prepared from the 1:1 copolymer of the two bismaleimide resins was excellent at both ambient and elevated temperatures. The physical and mechanical properties of the composites from the new bismaleimide matrix resin systems are compared with conventional composites based on epoxy and other bismaleimide systems. The copolymer system provides another method for improving bismaleimide resins.
Evaluating the Viscoelastic Properties of Tissue from Laser Speckle Fluctuations (2012)

Most pathological conditions such as atherosclerosis, cancer, neurodegenerative, and orthopedic disorders are accompanied with alterations in tissue viscoelasticity. Laser Speckle Rheology (LSR) is a novel optical technology that provides the invaluable potential for mechanical assessment of tissue in situ. In LSR, the specimen is illuminated with coherent light and the time constant of speckle fluctuations, τ, is measured using a high speed camera. Prior work indicates that τ is closely correlated with tissue microstructure and composition. Here, we investigate the relationship between LSR measurements of τ and sample mechanical properties defined by the viscoelastic modulus, G*. Phantoms and tissue samples over a broad range of viscoelastic properties are evaluated using LSR and conventional mechanical testing. Results demonstrate a strong correlation between τ and |G*| for both phantom (r = 0.79, p <0.0001) and tissue (r = 0.88, p<0.0001) specimens, establishing the unique capability of LSR in characterizing tissue viscoelasticity.
Enzymatic production of ribavirin from orotidine by Erwinia carotovora AJ 2992. (1988)

Microorganisms that produce ribavirin (1-β-D-ribofuranosyl-1, 2, 4-triazole-3-carboxamide; virazole®) directly from orotidine and 1, 2, 4-triazole-3-carboxamide (TCA) were screened from our stock cultures. Of the 425 strains, Erwinia carotovora AJ 2992 was found to possess potent ribavirin-producing ability, from orotidine and TCA. In the presence of intact cells of E. carotovora AJ 2992, 183 mM ribavirin was produced from 300 mM orotidine and 300 mM TCA on 48 hr reaction.
Abstract 3254: Discovery of S3I-1757, a STAT3-STAT3 dimerization disruptor that inhibits STAT3 activity, tumor survival, migration and invasion. (2013)

Abstract The ability of STAT3 to translocate to the nucleus, bind DNA and transcriptionally regulate STAT3 target genes depends on tyrosine phosphorylation STAT3-STAT3 dimerization. Our chemistry efforts led to the discovery of S3I-1757 that disrupts STAT3-STAT3 dimerization. Fluorescence polarization assays and molecular modeling show that S3I-1757 interacts with Y-705 binding site in the STAT3-SH2 domain and displaces fluorescein-labelled GpYLPQTV phosphotyrosine peptide from binding to STAT3. Furthermore, using co-immunoprecipitation and co-localization studies we show that S3I-1757 inhibits STAT3 dimerization and STAT3-EGF receptor binding in intact cells. Treatment of human cancer cells with S3I-1757 (but not a closely related analogue, S3I-1756, that does not inhibit STAT3 dimerization), inhibits selectively the phosphorylation of STAT3 over Akt and Erk1/2, nuclear accumulation of P-Y705-STAT3, STAT3-DNA binding and transcriptional activation and suppresses the expression levels of STAT3 target genes such as Bcl-xL, survivin, cyclin D1 and MMP9. Furthermore, S3I-1757 but not S3I-1756 inhibits anchorage-dependent and -independent growth, migration and invasion of human cancer cells which depend on STAT3 selectively over those that do not. Finally, STAT3-C, a genetically engineered mutant of STAT3 that forms a constitutively dimerized STAT3, rescues from S3I-1757 effects. Our results warrant further development of S3I-1757 as a STAT3-STAT3 dimerization inhibitor capable of blocking hyper activated STAT3 and suppressing malignant transformation of STAT3-dependent human tumors. Citation Format: Xiaolei Zhang, Ying Sun, Roberta Pireddu, Hua Yang, Murali K. Urlam, Harshani R. Lawrence, Wayne C. Guida, Nicholas J. Lawrence, Said M. Sebti. Discovery of S3I-1757, a STAT3-STAT3 dimerization disruptor that inhibits STAT3 activity, tumor survival, migration and invasion. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3254. doi:10.1158/1538-7445.AM2013-3254
Synchronous chaos in coupled oscillator systems (1994)

We investigate the synchronization of chaotic oscillations in coupled oscillator systems, both theoretically and in analog electronic circuits. Particular attention is paid to deriving and testing general conditions for the stability of synchronous chaotic behavior in cases where the coupled oscillator array possesses a shift-invariant symmetry. These cases include the well studied cases of nearest-neighbor diffusive coupling and all-to-all or global coupling. An approximate criterion is developed to predict the stability of synchronous chaotic oscillations in the strong coupling limit, when the oscillators are coupled through a single coordinate (scalar coupling). This stability criterion is illustrated numerically in a set of coupled R\"ossler-like oscillators. Synchronization experiments with coupled R\"ossler-like oscillator circuits are also carried out to demonstrate the applicability of the theory to real systems.
Post placement leakage reduction with stress-enhanced filler cells (2015)

A novel methodology for the post placement leakage reduction based on employment of the stress-enhanced filler (SEF) cells was developed. Desired reduction of sub-threshold leakage in test chip silicon was achieved by placement of SEF cells close to the most leaking devices. In the standard cell rows the “optimization zones”, representing portions of the row located between two consecutive fixed cells (clock cells, etc.), were defined. Mentor Graphics' stress assessment tool was used to find the optimal locations for SEF insertion inside each zone, providing the maximal increase of threshold voltage of the leakiest transistors. Measurements performed on the processed silicon test chip have confirmed the predicted leakage reduction of 10–15 percent while keeping same electrical performance.
Design of a Lossless Image Compression System for Video Capsule Endoscopy and Its Performance in In-Vivo Trials (2014)

In this paper, a new low complexity and lossless image compression system for capsule endoscopy (CE) is presented. The compressor consists of a low-cost YEF color space converter and variable-length predictive with a combination of Golomb-Rice and unary encoding. All these components have been heavily optimized for low-power and low-cost and lossless in nature. As a result, the entire compression system does not incur any loss of image information. Unlike transform based algorithms, the compressor can be interfaced with commercial image sensors which send pixel data in raster-scan fashion that eliminates the need of having large buffer memory. The compression algorithm is capable to work with white light imaging (WLI) and narrow band imaging (NBI) with average compression ratio of 78% and 84% respectively. Finally, a complete capsule endoscopy system is developed on a single, low-power, 65-nm field programmable gate arrays (FPGA) chip. The prototype is developed using circular PCBs having a diameter of 16 mm. Several in-vivo and ex-vivo trials using pig's intestine have been conducted using the prototype to validate the performance of the proposed lossless compression algorithm. The results show that, compared with all other existing works, the proposed algorithm offers a solution to wireless capsule endoscopy with lossless and yet acceptable level of compression.
Engineering high-level aluminum tolerance in barley with the <i>ALMT1</i> gene (2004)

Acidity is a serious limitation to plant production on many of the world's agricultural soils. Toxic aluminium (Al) cations solubilized by the acidity rapidly inhibit root growth and limit subsequent uptake of water and nutrients. Recent work has shown that the ALMT1 gene of wheat (Triticum aestivum) encodes a malate transporter that is associated with malate efflux and Al tolerance. We generated transgenic barley (Hordeum vulgare) plants expressing ALMT1 and assessed their ability to exude malate and withstand Al stress. ALMT1 expression in barley conferred an Al-activated efflux of malate with properties similar to those of Al-tolerant wheat. The transgenic barley showed a high level of Al tolerance when grown in both hydroponic culture and on acid soils. These findings provide additional evidence that ALMT1 is a major Al-tolerance gene and demonstrate its ability to confer effective tolerance to acid soils through a transgenic approach in an important crop species.
Precision for Bigger Diameters: The World's First 4 Tube Coriolis Mass Flowmeter (2012)

Abstract The introduction of the Coriolis mass flow measuring principle was a milestone in instrumentation. By offering the most accurate direct mass flow measurement in situ, combined with the possibility of measuring density at the same time, it enabled customers in a variety of industries to profit from the most convenient metering even in challenging applications, where other measurement principles reached their limits. Alas the geometrical designs of the meters on the market seemed to have reached a natural barrier at 12" pipe diameters. However, the higher the masses flowing through the pipelines, the more important the lowest error of measurement possible becomes. In hydrocarbon measurement this is apparent. The paper presents the world's first commercial Coriolis mass flow meter with 4 tubes. The working principle is explained and the geometrical and physical advantages of the 4-tube design compared to existing 2-tube designs are highlighted. The paper also reflects on the mechanical construction of Coriolis mass flow meters in general and highlights the importance of a sophisticated mechanical concept.
Suitability of the prfA gene, which encodes a regulator of virulence genes in Listeria monocytogenes, in the identification of pathogenic Listeria spp (1992)

The pathogenesis of listerial infections is complex and involves a number of virulence factors expressed by virulent Listeria species. We have recently described a regulator gene, prfA, that positively regulates the expression of a number of virulence factors in Listeria monocytogenes. When the prfA gene was used as a DNA probe, we found it to be extremely specific for the pathogenic species L. monocytogenes. No reaction was obtained with strains of all other species of this genus. By using this information, an oligonucleotide primer pair was developed that specifically amplifies the prfA gene in L. monocytogenes strains of all known serotypes.
Adaptive blind equalization for coherent optical BPSK system (2010)

The widely used CMA equalization fails in coherent optical BPSK systems. A novel adaptive blind equalization method is proposed and experimentally verified in terms of frequency offset, laser linewidth, CD/PMD and polarization scrambling tolerance.
353 A Study on Sound Quality Design and Evaluation Method for Golf Club : Influence of a structural Characteristic for Sound Quality Evaluation (2009)

Sound quality of hitting sound becomes important in design of golf club. In this paper, four simple experiment models produced to examine the vibrational characteristic of the golf clubs. First, the results of the numerical analysis of the models and the results of the experiment are compared, and the effectiveness of the numerical model is shown. Finally, it is examined the influence that a structural change in the golf clubs give to the sound quality of the hitting sound is predictable by the use of the frequency parameter for sound quality parameters.
Cloning and in vitro Expression of the Gene for the E3 Haemagglutinin Glycoprotein of Bovine Coronavirus (1989)

SUMMARY A cDNA clone representing the gene for the E3 glycoprotein, the haemagglutinin, of bovine coronavirus was isolated from a plasmid cDNA library of the viral genome and sequenced. The gene is located immediately 5′ of the E2 glycoprotein gene on the viral genome. Nucleotide sequencing of the E3 gene predicts a polypeptide of 424 amino acids with an M r of 47K. In vitro translation of mRNA transcribed from the cloned E3 gene yielded a polypeptide of M r 45K, similar to that predicted from the nucleotide sequence. In the presence of microsomal membranes, the in vitro product was cotranslationally processed to a 62K polypeptide which comigrated on SDS–polyacrylamide gels with the E3 monomer (gp62) obtained from virus-infected cells. Both the 45K and 62K polypeptides were immunoprecipitated with E3-specific monoclonal antibodies, confirming the identity of the gene as that encoding the E3 glycoprotein. Finally, only monoclonal antibodies to the E3 protein inhibited haemagglutination by the virus thus confirming its identity as the haemagglutinin of bovine coronavirus.
Laser measuring system for wire-wrapped frame assemblies (1979)

The laser measuring system is designed to automatically measure and record the distances between small diameter wires on a wire wrapped grid frame assembly to an accuracy of 0.00635 mm (0.00025 in.). The system utilizes a helium-neon gas laser beam as the measuring instrument with a remote interferometer and retroreflector, a light source and photodetector to detect the wire positions, in conjunction with recording, display and printout units. The laser measuring system is utilized to perform precise automatic measurements for wire application machines or as an automatic feedback device for positioning wires and/or to adjust them for out of tolerance conditions.
III-nitride disk-in-nanowire 1.2 <i>μ</i>m monolithic diode laser on (001)silicon (2015)

III-nitride nanowire diode heterostructures with multiple In0.85Ga0.15N disks and graded InGaN mode confining regions were grown by molecular beam epitaxy on (001)Si substrates. The aerial density of the 60 nm nanowires is ∼3 × 1010 cm−2. A radiative recombination lifetime of 1.84 ns in the disks is measured by time-resolved luminescence measurements. Edge-emitting nanowire lasers have been fabricated and characterized. Measured values of Jth, T0, and dg/dn in these devices are 1.24 kA/cm2, 242 K, and 5.6 × 10−17 cm2, respectively. The peak emission is observed at ∼1.2 μm.
Adriamycin analogs. Rationale, synthesis, and preliminary antitumor evaluation of highly active DNA-nonbinding N-(trifluoroacetyl)adriamycin 14-O-hemiester derivatives (1985)

N-(Trifluoroacetyl)adriamycin 14-valerate (AD 32), a novel DNA nonbinding analogue of adriamycin with superior experimental antitumor activity, has undergone extensive clinical trial, with documentation of antitumor activity and low toxicity in human subjects. However, poor water solubility necessitates that the drug be administered to patients by continuous intravenous infusion at high dilution in a surfactant-containing formulation, with steroid prophylaxis to protect against a chest pain syndrome associated with the vehicle. On the basis of pharmacologic considerations, the title compounds have been prepared as second-generation analogues of N-(trifluoroacetyl)adriamycin 14-valerate with improved aqueous solubility; use is made of the available carboxylic acid function to solubilize the products in dilute aqueous alkaline medium. Target compounds were made by treating N-(trifluoroacetyl)-14-halodaunorubicin (bromo or iodo) with monosodium salts of dibasic acids (malonic, succinic, glutaric, adipic, pimelic, azelaic, sebacic) in aqueous acetone. All of the products showed significant in vivo antitumor activity against the murine P388 leukemia (ip tumor, ip treatment once daily on days 1, 2, 3, and 4); most compounds were superior to the +181% increase in life span afforded by adriamycin (optimal dose 3.0 mg/kg per day), one of two drugs used as positive controls for the assays. Several of the test compounds showed highly curative activity in this system, similar to N-(trifluoroacetyl)adriamycin 14-valerate, the other positive control agent. The hemiadipate product exhibited the most desirable properties of high antitumor efficacy (86% cure rate all P388 tumor-bearing animals through four levels of a 40-70 mg/kg dose-response range), aqueous solubility (60 mg/mL in pH 7.4 phosphate buffer), and solution stability (no decomposition at 4 degrees C, 0.5% hydrolysis at 27 degrees C, over 24 h at pH 7.4).
Parameter space representation of liquid crystal display operating modes (1996)

A parameter space approach is used to represent the operation of all liquid crystal displays. The Jones matrix nematic is used to analyze the static optical properties of liquid crystal displays with any twist angle, cell thickness, natural birefringence, and polarizer angles. All the usual display modes such as 90° TN, ECB, OMI, SBE, and STN can be visualized on a simple parameter space diagram. Besides its pedagogical values, this formulation has the advantage of simplicity in showing the physics and operating conditions of supertwist as well as low twist liquid crystal displays. It can also be used to analyze novel situations such as reflective displays which do not require any back polarizer.
Employing cavity ring-down spectroscopy to probe dilute species in hostile environments (1998)

Summary form only given, as follows. Cavity ring-down spectroscopy (CRDS) is newly developed spectroscopic technique which may be used to determine the concentration of very dilute gas-phase species present in hostile environments. Unlike traditional absorption techniques which measure the attenuation of light passing through a sample, in CRDS light from a pulsed laser is injected into a high-finesse cavity formed by two or more high reflectivity mirrors. Light leaking from the resonator through one of the mirrors is then used to measure the rate of decay of the pulse of light within the cavity. Absorption by species present within the resonator increase the rate of decay of light in the cavity. Therefore, by measuring this ring-down rate with and without sample present within the resonator, the absorbance of the sample may be measured and its absolute concentration determined. The largest advantage of CRDS is its insensitivity to fluctuations in the intensity of the light source; these fluctuations limit the sensitivity of traditional absorption techniques. Furthermore, since the decay of coherent light from the resonator is being detected, CRDS may be used to measure species in environments with high background radiation levels such as flames and discharges. Advancements in the use of this technique to measure the concentration of species in hostile environments will be discussed as well as the application of continuous-wave laser sources to the technique.
The ADAM10 Prodomain Is a Specific Inhibitor of ADAM10 Proteolytic Activity and Inhibits Cellular Shedding Events (2007)

ADAM10 is a disintegrin metalloproteinase that processes amyloid precursor protein and ErbB ligands and is involved in the shedding of many type I and type II single membrane-spanning proteins. Like tumor necrosis factor-alpha-converting enzyme (TACE or ADAM17), ADAM10 is expressed as a zymogen, and removal of the prodomain results in its activation. Here we report that the recombinant mouse ADAM10 prodomain, purified from Escherichia coli, is a potent competitive inhibitor of the human ADAM10 catalytic/disintegrin domain, with a K(i) of 48 nM. Moreover, the mouse ADAM10 prodomain is a selective inhibitor as it only weakly inhibits other ADAM family proteinases in the micromolar range and does not inhibit members of the matrix metalloproteinase family under similar conditions. Mouse prodomains of TACE and ADAM8 do not inhibit their respective enzymes, indicating that ADAM10 inhibition by its prodomain is unique. In cell-based assays we show that the ADAM10 prodomain inhibits betacellulin shedding, demonstrating that it could be of potential use as a therapeutic agent to treat cancer.
Development of a Smooth Muscle–Targeted Cre Recombinase Mouse Reveals Novel Insights Regarding Smooth Muscle Myosin Heavy Chain Promoter Regulation (2000)

The use of genetically modified mice has been an important model system to study gene function in cardiovascular development and under pathophysiological conditions. Although conventional gene knockout studies have provided important insights into gene function in the cardiovascular system, they may be limited by upregulation of compensatory pathways and the inability to differentiate direct versus indirect functions in vivo. As a first step in developing systems that can target gene activation or inactivation specifically to smooth muscle cells (SMCs), we coupled the smooth muscle myosin heavy chain (SMMHC) promoter to the cre recombinase gene and generated transgenic mice that express cre in SMCs. In addition, we used these mice to address whether the heterogeneous staining observed in SMMHC-LacZ mice was due to subsets of SMCs that required different regulatory cassettes of the promoter or if it reflected episodic expression of the transgene. To address both the feasibility of SMC targeting and the apparent heterogeneous expression, we bred SMMHC-cre mice to indicator mice containing a cre-activated LacZ gene. Results showed high-level expression in SMCs at various embryonic time points and in adult tissues. Because breeding of SMMHC-cre mice to an indicator line provided an integration of cre activity over time, results of this study revealed that expression of the SMMHC promoter fragment more closely resembled the expression of the endogenous gene, both with respect to the onset of activation during development and uniformity of staining among individual cells within tissues. Overall, these mice will provide a powerful tool to researchers to study gene function in vascular development/disease by using cre/lox technology to direct smooth muscle-specific gene activation or inactivation in vivo.
Identification of the Minimal Active Sequence of an Anti-Influenza Virus Peptide (2011)

The antiviral peptide, entry blocker (EB), inhibits influenza virus replication by preventing attachment to cells. Here, we identified the minimal and optimal EB sequence that retained antiviral activity with a 50% inhibitory concentration (IC(50)) and 50% effective concentration (EC(50)) similar to those of the full-length EB peptide and several truncated variants that possessed up to 10-fold lower IC(50)s. These data have implications for improving the antiviral efficacy of EB-derived peptides while decreasing production costs and easing synthesis.