gebhart/patrepeval huggingface dataset:
DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer (2013)

Small cell lung cancer (SCLC) is one of the most aggressive types of cancer, yet the pathologic mechanisms underlying its devastating clinical outcome remain elusive. In this report, we surveyed 924 miRNA (miR) for their expressions in the formalin-fixed paraffin-embedded specimens from 42 patients with SCLC, and found that the downregulated miR-886-3p is closely correlated with the shorter survival of SCLC. This correlation was validated with another 40 cases. It was further discovered that loss of miR-886-3p expression was mediated by DNA hypermethylation of its promoter in both cultured SCLC cells and tumor samples. Moreover, miR-886-3p potently repressed cell proliferation, migration, and invasion of NCI-H446 cell in cell culture via suppression of the expression of its target genes: PLK1 and TGF-β1 at posttranscription levels. Forced upregulation of miR-886-3p greatly inhibited in vivo tumor growth, bone/muscle invasion, and lung metastasis of NCI-H446 cells. This newly identified miR-886-3p-PLK1/TGF-β1 nexus that modulates SCLC aggression suggests that both loss of miR-886-3p expression and hypermethylation of the miR-886 promoter are the promising indicators for poor outcome of as well as new therapeutic targets for SCLC.
Module for optical logic circuits using symmetric self-electrooptic effect devices (1990)

An optical module designed to perform cascadable optical logic using arrays of symmetric self-electrooptic effect devices (S-SEEDs) is described. The operation of an array of 7 x 3 devices with optical windows spaced by 20 microm is demonstrated including both array preset and individual device switching. The issues leading to the design of this optical system are detailed. This work illustrates some of the issues which must be considered when designing systems using small reflecting electrooptic devices such as SEEDs and free-space optics in digital systems.
Dithiocarbamates: Reliable Surface Ligands for NIR-Emitting Quantum Dots (2019)

In this paper, we report a reliable method for transferring hydrophobic, NIR-emitting PbS/CdS core-shell quantum dots (QDs) to water solutions using synthesized in situ dithiocarbamate derivatives of amino acids as stabilizing ligands. Such ligands offer apparent advantages over dihydrolipoic acid (DHLA) derivatives commonly used as ligands stabilizing quantum dots. The most effective phase transfer and the best long-term stability of water dispersions of amino acid-DTC-capped QDs were achieved using lysine dithiocarbamate. In this case, the phase transfer of PbS/CdS nanoparticles from organic to aqueous phase can be completed in 6-8 h. Prepared amino acid-DTC-capped QDs nanoparticles have narrow size distributions, and their hydrodynamic diameter remains below 9 nm. After transferring to water, lysine-DTC-capped PbS/CdS nanoparticles retain their spectroscopic properties for at least 48 h. Moreover, they are not toxic up to concentration corresponding to about 7 μg/cm<sup>3</sup> of PbS/CdS, which is sufficient for their application in biological systems. In addition, lysine-DTC-capped PbS/CdS QDs can be straightforwardly modified by layer-by-layer polyelectrolyte coating.
Effect of crystallization heat treatment on the microstructure of niobium‐doped fluorapatite glass‐ceramics (2012)

Our goal was to study the effect of heat treatment temperature and heating rate on the microstructure and crystalline phases and assess the domain of existence of submicrometer fluorapatite crystals in niobium-doped fluorapatite glass-ceramics for biomedical applications. Glass-ceramic specimens were prepared by casting and heat treatment between 700 and 1200°C using a fast or a slow heating rate. The microstructure was characterized by atomic force microscopy and scanning electron microscopy. Crystalline phases were analyzed by x-ray diffraction. AFM of the as-cast glass revealed that amorphous phase separation occurred in this system. XRD confirmed the presence of fluorapatite in all specimens, together with forsterite and enstatite at higher temperatures. Both heating rate and heat treatment temperature strongly influenced microstructure and crystallinity. A dual microstructure with submicrometer fluorapatite crystals and polygonal forsterite crystals was obtained when slow heating rates and crystallization temperatures between 950 and 1100°C were used. Needle-shaped fluorapatite crystals appeared after heat treatment above 1100°C. Fast heating rates led to an increase in crystal size. Heat treatment temperatures should remain below 1100°C, together with slow heating rates, to prevent crystal dissolution, and preserve a dual microstructure of finely dispersed submicrometer crystals without growth of needle-shaped crystals.
MIXI: Mobile Intelligent X-Ray Inspection System (2016)

A novel, low-dose Mobile Intelligent X-ray Inspection (MIXI) concept is being developed at RadiaBeam Technologies. The MIXI concept relies on a linac-based, adaptive, ramped energy source of short X-ray packets of pulses, a new type of fast X-ray detector, rapid processing of detector signals for intelligent control of the linac, and advanced radiography image processing. The key parameters for this system include: better than 3 mm line pair resolution; penetration greater than 320 mm of steel equivalent; scan speed with 100% image sampling rate of up to 15 km/h; and material discrimination over a range of thicknesses up to 200 mm of steel equivalent. Its minimal radiation dose, size and weight allow MIXI to be placed on a lightweight truck chassis.
360° video stabilization (2016)

We present a hybrid 3D-2D algorithm for stabilizing 360° video using a deformable rotation motion model. Our algorithm uses 3D analysis to estimate the rotation between key frames that are appropriately spaced such that the right amount of motion has occurred to make that operation reliable. For the remaining frames, it uses 2D optimization to maximize the visual smoothness of feature point trajectories. A new low-dimensional flexible deformed rotation motion model enables handling small translational jitter, parallax, lens deformation, and rolling shutter wobble. Our 3D-2D architecture achieves better robustness, speed, and smoothing ability than either pure 2D or 3D methods can provide. Stabilizing a video with our method takes less time than playing it at normal speed. The results are sufficiently smooth to be played back at high speed-up factors; for this purpose we present a simple 360° hyperlapse algorithm that remaps the video frame time stamps to balance the apparent camera velocity.
Some microwave applications of BaSrTiO<sub>3</sub> and high temperature superconductors (1995)

Abstract The group at the University of Colorado has been working on the applications of BaSrTiO3 and high temperature superconductors to microwave circuits and systems with support from Superconducting Core Technologies, NASA and ONR. This work has included the development of a voltage tunable oscillator, a phase shifter, and a voltage tunable phased array antenna system. An important aspect of this program is the lattice match between the high temperature superconductor and the ferroelectric materials which enables us to grow thin films of either material on each other. By choosing the appropriate barium stronium ratio we are able to obtain changes in the dielectric constant of 5 to 1 in bulk capacitors at 77 K, the liquid nitrogen boiling temperature. Phase shifts of a little less than 126° at 10 Ghz have been obtained by applying 5 volts on a one centimeter coplanar line. The proposed phased array systems should enable us to point the beam radiated from the antenna in an arbitrary direction using two control voltages of less than 50 volts. We believe this approach leads to the possibility of inexpensive electronically scannable antenna systems which could be used for mobile communications with satellites and cellular systems.
Development of an Industrial Multi‐Injection Microreactor for Fast and Exothermic Reactions – Part II (2008)

Abstract A Grignard reaction performed in a microreactor is presented. The reaction is of type A (highly exothermic and very rapid) and has a low yield which is attributed to a hot spot formed in the mixing zone of the reactor. The reaction yield could be significantly increased by applying the multi‐injection principle, leading to better thermal control in the microreactor. Nevertheless, the microreactor plays a major role in reducing the magnitude of the hot spot. Knowing this, it was possible to design and construct an industrial microreactor with significant advantages such as modularity, high flow rate operation, and low investment expenditure (pumps and flow controller minimization).
Funktionelle Derivate von Phenoxyplienoxypropionsäuren und ihre herbizide Wirksamkeit / Derivatives of Phenoxyphenoxypropionic Acids and their Herbicidal Activity (1982)

Abstract Derivates of phenoxyphenoxypropionic Acids are herbicids with high activity. Methods to synthesis these compounds are reviewed. Relationship between structure and herbicidal activity are discussed.
Implementation and Performance Evaluation of RNS Variants of the BFV Homomorphic Encryption Scheme. (2018)

Homomorphic encryption is an emerging form of encryption that provides the ability to compute on encrypted data without ever decrypting them. Potential applications include aggregating sensitive encrypted data on a cloud environment and computing on the data in the cloud without compromising data privacy. There have been several recent advances resulting in new homomorphic encryption schemes and optimized variants. We implement and evaluate the performance of two optimized variants, namely Bajard-Eynard-Hasan-Zucca (BEHZ) and Halevi-Polyakov-Shoup (HPS), of the most promising homomorphic encryption scheme in CPU and GPU. The most interesting (and also unexpected) result of our performance evaluation is that the HPS variant in practice scales significantly better (typically by 15-30 percent) with increase in multiplicative depth of the computation circuit than BEHZ, implying that the HPS variant will always outperform BEHZ for most practical applications. For the multiplicative depth of 98, our fastest GPU implementation performs homomorphic multiplication in 51 ms for 128-bit security settings, which is faster by two orders of magnitude than prior results and already practical for cloud environments supporting GPU computations. Large multiplicative depths supported by our implementations are required for applications involving deep neural networks, logistic regression learning, and other important machine learning problems.
Electrically tunable, diode-pumped erbium-doped fibre ring laser with fibre Fabry–Perot etalon (1991)

An all fibre, diode-pumped, electrically tunable ring laser is reported. Gain is provided by an erbium-doped fibre and tuning by a fibre Fabry-Perot etalon. The threshold at l.566 μm is 2.9mW, the slope efficiency is 0.15 and the output power is 4.2 mW with 32 mW of pump power. The output wavelength can be tuned from 1.525 to 1.586 μm with a variation in power of less than 3.5 dB.
Abstract LB-470: Tumor suppressor role of microRNA-18b in melanoma (2012)

Abstract MicroRNAs play important roles in gene regulation, and their expression is frequently dysregulated in various tumors. Here, we report that expression of miR-18b is significantly suppressed in melanoma specimens when compared with nevi. miR-18b is silenced in melanoma cell lines due to hypermethylation and is re-expressed by 5-AZA-deoxycytidine (5-AZA) in melanoma cell lines. miR-18b overexpression suppressed cell survival, colony formation, invasiveness and migratory ability and induced apoptosis in melanoma cell lines. Stable overexpression of miR-18b suppressed melanoma cell proliferation, colony formation, and tumor cell growth in-vivo. miR-18b reverses epithelial-to-mesenchymal transition in melanoma cell lines and its expression was induced by the chemotherapeutic drug cisplatin. These results demonstrate a novel role for miR-18b as a tumor suppressor in melanoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-470. doi:1538-7445.AM2012-LB-470
Artificial redox enzymes. Part 3. Structure and properties (1992)

The structural and catalytic properties of models of flacoenzymes in which flavin is covalently attached to the catalytically important secondary side of 2-[(7α-O-10-methyl-7-isoalloxazinyl)-methyl]-α-cyclodextrin and 2-[(7α-O-10-methyl-7-isoalloxazinyl)methyl]-β-cyclodextrin as well as the primary side 6-(10-N-isoalloxazinylmethyl)-β-cyclodextrin are reported.
A 40-Gb/s Clock and Data Recovery Circuit in (2003)

Abstract—A phase-locked clock and data recovery circuit incorporates a multiphase LC oscillator and a quarter-rate bang-bang phase detector. The oscillator is based on differential excitation of a closed-loop transmission line at evenly spaced points, providing half-quadrature phases. The phase detector employs eight flip-flops to sample the input every 12.5 ps, detecting data transitions while retiming and demultiplexing the data into four 10-Gb/s outputs. Fabricated in 0.18- m CMOS technology, the circuit produces a clock jitter of 0.9 ps�� � and 9.67 ps� � with a PRBS of PQI I while consuming 144 mW from a 2-V supply. Index Terms—CDR circuits, demultiplexers, injection locking, oscillators, phase detectors, phase-locked loops. I.
Two-Dimensional Photonic Crystal Material in Fibre form (1996)

Photonic crystals are formed of periodically structured dielectric material, the pitch or period of the structure being of the order of the optical wavelength. A novel property of photonic crystal materials is they can be designed so as to exhibit photonic bandgaps. i.e. frequency ranges in which there are no propagating modes in the material. 1 Some interesting consequences of such photonic band gaps occur for waves propagating out-of-plane in two-dimensionally periodic materials. One possibility is to fabricate low-loss waveguides which guide solely by Bragg reflection. 2 This could be done by using a 2-D structure which is effectively infinite in the third dimension, and which exhibits a bandgap in its transmission characteristics for waves which have a certain wavevector component β= k. along the structure. By purposefully introducing some kind of defect which is embedded in the crystal structure we can create a spatially localized region where such a wave can exist - a "defect stale" appears in the band structure of the material. Light in this defect state would be unable to leak away from the defect through the crystal material, but would travel along the defect with propagation constant β.
Progress in high pressure sodium lamp technology (1993)

This paper reviews the most important technological advances in high pressure sodium lamp technology in the past decade. The basic effects of increasing the xenon starting gas pressure on the electrical and photometric lamp characteristics are discussed. The implications for a practical high xenon pressure product are also briefly reviewed. The basis of colour improved lamps, both the AC and the pulsed current versions, is explained. It is then demonstrated how the different colour improved commercial lamps are derived. The basic difference between saturated and unsaturated HPS lamps is explained by considering different dosing schemes, then the advantages of an unsaturated HPS lamp over a saturated one is demonstrated and finally, a brief description of the effects of omitting mercury from the HPS discharge vessel is given and it is suggested how a practical mercury-free lamp with good efficacy and life could be derived.
Control of limit cycles in recursive digital filters by randomized quantization (1977)

The different types of limit cycles which can occur in single second-order sections respond differently to efforts to reduce them. Length 1 (dc) limit cycles play an important complicating role, especially in cascaded filters. We describe a simple method, involving random requantization of multiplier outputs, which can reduce or eliminate limit cycles in digital filters. We compare limit cycle and roundoff noise in three typical low-pass filters with and without the method.
A performance and implementation comparison of bidirectional and dual bus 2-D WDM multiple-plane optical interconnections with row-column multihop network structures (2001)

Bidirectional and dual bus wavelength division multiplexing (WDM) two-dimensional (2-D) multiple-plane optical interconnections with row-column multihop network structures using vertical-cavity surface-emitting lasers (VCSELs) and wavelength-selective detectors are analyzed and compared in terms of the expected number of hops (switching delay) and practical implementation considerations. The bidirectional WDM optical interconnection significantly reduces the necessary implementation hardware while maintaining the performance very closely compared to the dual bus architecture. Both WDM structures show significant performance improvements even when only three to five wavelengths are used. Also, the multihop efficiency is analyzed with the consideration of both electrical hops and optical hops.
The interactive effects of pH, surface tension, and solution density for flotation systems for separation of equivalent-density materials: separation of ABS from HIPS (1996)

This paper presents the results of research being conducted at Argonne National Laboratory, to develop a cost-effective and environmentally acceptable process for the separation of high-value plastics from discarded household appliances. The process under development has separated high-purity (greater than 99.5%) acrylonitrile-butadiene-styrene (ABS) and high-impact polystyrene (HIPS) from commingled plastics generated by appliance-shredding and metal recovery operations. Plastics of similar densities, such as ABS and HIPS are further separated by using a chemical solution. By controlling the surface tension, the density and the temperature of the chemical solution, we are able to selectively float/separate plastics that have equivalent densities. In laboratory-scale tests, this technique has proven highly effective in recovering high-purity plastics materials from discarded household appliances and other obsolete durable goods. A pilot plant is under construction to demonstrate and assess the technical and economic performance of this process. In this paper, we examine the technical and economic issues that affect the recovery and separation of plastics and provide an update on Argonne`s plastics separation research and development activities.
A current density mapping approach for the design of clinical MRI magnets (2000)

A new current density mapping (CDM) scheme has been developed for the design of compact clinical magnetic resonance imaging magnets with active shielding. This technique is based on the inverse current density approach by solving a Fredholm equation of the first kind. A non-linear optimization method with inequality constrains is then invoked to fit practical magnet coils to the desired current density. The primary objective was to develop new numerical optimization techniques for the compact symmetric (conventional) magnets and for the newly developed asymmetric magnet concept. One of the advantages of the method is that new concepts in superconducting magnet design may be rapidly investigated.
Test response compactor with programmable selector (2006)

The paper presents an efficient method for synthesis of scan chain selection logic. It is capable of acting as a flexible X-control logic for test response compactors. The same circuitry can also be employed to selectively gate scan chains for diagnostic purposes.
ChemInform Abstract: Superhard Mixed Transition Metal Dodecaborides. (2016)

Abstract The solid solutions Zr 1‐x Y x B 12 , Zr 1‐x Sc x B 12 , and Y 1‐x Sc x B 12 (x = 0—1) as well as ScB 50 and YB 66 are prepared by arc‐melting of the elements in ratios of 1:20 for the dodecaborides and 1:65 and 1:70 for the latter two binary phases.
Real-time combinatorial tracking of a target moving unpredictably among obstacles (2003)

Many applications require continuous monitoring of a moving target by a controllable vision system. Although the goal of tracking objects is not new, traditional techniques usually ignore the presence of obstacles and focus on imaging and target recognition issues. For a target moving among obstacles, the goal of tracking involves a complex motion problem: a controllable observer must anticipate that the target may become occluded by an obstacle and move to prevent such an event from occurring. The paper describes a strategy for computing the motions of a mobile robot operating in a 2-D workspace without prior knowledge of the target's intention or the distribution of obstacles in the scene. The proposed algorithm governs the motion of the observer based on current measurements of the target's position and the location of the local obstacles. The approach is combinatorial in the sense that the algorithm explicitly computes a description of the geometric arrangement between the target and the observer's visibility region produced by the local obstacles. The algorithm computes a continuous control law based on this description. The new tracking strategy has been implemented in a real-time robotic system.
Performance of diode-pumped Nd:YAG and Nd:YLF lasers in a tightly folded resonator configuration (1992)

The performance of diode bar pumped Nd:YAG and Nd:YLF lasers in a novel tightly folded resonator configuration is described. For Nd:YLF at a pump level of 9.2 W a TEM/sub 00/ output power of 3.1 W with a slope efficiency of 47% was observed. In Q-switched operation a pulse energy of 0.7 mJ and a pulsewidth of 5 ns were obtained. The same resonator design configured to operate as an optical amplifier provides small-signal gain of 28 dB and average output powers of greater than 1 W. >
Space Station Cathode Design, Performance, and Operating Specifications (1998)

A plasma contactor system was baselined for the International Space Station (ISS) to eliminate/mitigate damaging interactions with the space environment. The system represents a dual-use technology which is a direct outgrowth of the NASA electric propulsion program and, in particular, the technology development efforts on ion thruster systems. The plasma contactor includes a hollow cathode assembly (HCA), a power electronics unit, and a xenon gas feed system. Under a pre-flight development program, these subsystems were taken to the level of maturity appropriate for transfer to U.S. industry for final development. NASA's Lewis Research Center was subsequently requested by ISS to manufacture and deliver the engineering model, qualification model, and flight HCA units. To date, multiple units have been built. One cathode has demonstrated approximately 28,000 hours lifetime, two development unit HCAs have demonstrated over 10,000 hours lifetime, and one development unit HCA has demonstrated more than 32,000 ignitions. All 8 flight HCAs have been manufactured, acceptance tested, and are ready for delivery to the flight contractor. This paper discusses the requirements, mechanical design, performance, operating specifications, and schedule for the plasma contactor flight HCAs.