gebhart/patrepeval huggingface dataset:
Subchronic Vapor Inhalation Toxicity Studies on 3.1 Oil in Male Fischer 344 Rats (1991)

3.1 Oil is a chlorofluorocarbon oil consisting of C6 and C8 oligomers of chlorotriflu-oroethylene. Physical properties such as high thermal stability, good lubricity, and high dielectric strength make 3.1 oil promising for potential use in hydraulic fluid systems. A previous inhalation study indicated that the liver is the target organ of 3.1 oil toxicity. Cross liver hypertrophy and microscopic hepatocytomegaly were the prime lesions noted. To determine a no-effect concentration, male Fischer 344 rats were exposed to air only, or vapor concentrations of 10, 50, or 250 mg 3.1 oil/m3 for 13 wk. Mean body weights of the highest concentration test group were slightly, but not significantly, depressed during the final two-thirds of the study. Alkaline phosphatase and blood urea nitrogen values were increased in this group at sacrifice. Significant concentration-related increases in relative kidney and liver weights occurred in the 250 and 50 mg 3.1 oil/m3 groups. Hyaline droplet distribution and severity was greater in the high-exposure group of rats. Hepatocytomegaly was a common finding in all rats exposed at these concentrations; however, this lesion resolved by dmo postexposure. Examination of hepatocytic ultrastructure revealed slightly swollen mitochondria in the two highest exposure groups. The number of peroxisomes per visual field was significantly greater in the highest exposure group only. The associated activity of peroxisomal β-oxidation of palmitoyl coenzyme A (CoA) also showed a concentration-dependent increase. Although an increase in this enzyme was noted, 70 mg 3.7 oil/m3 was identified as a no-effect level based on light and electron microscopic, hematologic, and in-life data.
Trastorno bipolar y multiimpulsividad en una muestra de 181 mujeres con trastornos de la conducta alimentaria, atendidas en Bogotá: prueba de un modelo de asociación para valoración del riesgo (2003)

Abstract Bipolar Disorder with atypical features in adolescents and the limitations of the categorical classifications ,are a challenge for an early diagnosis and treatment. Additionally, studies exploring this co morbidity in Eating Disorder patients are limited and inconsistent. This study explores the Bipolar Disorder prevalence in a woman population with Anorexia nervosa, Bulimia nervosa and EDNOS and Multi-Impulsivity. Objectives 1. Establish the BD prevalence in an 181 women sample with Eating Disorder and compare the findings with other epidemiological studies. 2. Describe and analyze the proposed variables in an association model to analyze their impact in BD risk. Design Transversal study and prove of an association model with Logistic Regression. Results In this sample, 14 patients with BD II or III (7.73%) were founded. 86% (12) have been presenting mixed episodes with rapid and ultra- rapid cycles. The proposed association model suggest that patients with multi-impulsivity behaviors like auto-mutilations, suicide attempts, kleptomania, trycotilomania, substance abuse coexisting with eating behavior like binges or purges, with transition symptoms history, under 23 years of age, and with bipolar disorder relatives , have an odds ratio 38 times greater for BD than the odds of a subject without this risk variables (OR= 37.45 , IC 95% 5-282).
Selective Surface Modification of SiO<sub>2</sub>−TiO<sub>2</sub> Supports with Phosphonic Acids (2004)

The selective surface modification by phosphonic acids of SiO2−TiO2 supports at the micrometer and molecular scale was investigated. Under aqueous conditions, phosphonic acids bind to TiO2 and not to SiO2 surfaces. A micropatterned support was prepared by electron beam microlithography and selectivity, of the surface modification was evidenced using scanning Auger electron spectroscopy (SAES). The second support was a mesoporous SiO2−TiO2 mixed oxide (10 mol % Ti) epoxidation catalyst prepared by sol−gel processing. Selectivity was deduced from the decrease of the catalytic activity upon modification and from chemical analysis; bonding modes to the surface were investigated using solid-state 29Si and 31P MAS NMR. The possibility to introduce different organic groups by successive treatments with a phosphonic acid and a silylating agent was illustrated in the case of the mixed oxide.
An efficient route to vinylporphyrins (1990)

The use of 1-bromo-19-methylbiladienes-ac in the synthesis of vinylporphyrins is described. The effect of the vinyl precursors on the reactions of the dipyrromethene intermediates and the construction of the linear tetrapyrrole are discussed. High-yield syntheses of a methylvinylporphyrin, an H-vinyl analogue, as well as two A,C-divinylporphyrins are presented. Keywords: pyrrole, dipyrromethene, acetoxyethylpyrrole, chloroethylpyrrole, biladiene-ac, porphyrin, vinylporphryin, benzoporphyrin, decarboxylation, transesterification.
Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation (2021)

Tumour metastasis is the main cause of postoperative tumour recurrence and mortality in patients with hepatocellular carcinoma (HCC), but the underlying mechanism remains unclear. Accumulating evidence has demonstrated that programmed cell death 10 (PDCD10) plays an important role in many biological processes. However, the role of PDCD10 in HCC progression is still elusive. In this study, we aimed to explore the clinical significance and molecular function of PDCD10 in HCC. PDCD10 is significantly upregulated in HCC, which also correlates with aggressive clinicopathological characteristics and predicts poor prognosis of HCC patients after liver resection. High PDCD10 expression promotes HCC cell proliferation, migration, and invasion in vitro and tumour growth, metastasis in vivo. In addition, PDCD10 could facilitate epithelial-to-mesenchymal transition (EMT) of HCC cells. In terms of the mechanism, PDCD10 directly binds to the catalytic subunit of protein phosphatase 2A (PP2Ac) and increases its enzymatic activity, leading to the interaction of YAP and dephosphorylation of the YAP protein. This interaction contributes to YAP nuclear translocation and transcriptional activation. PP2Ac is necessary for PDCD10-mediated HCC progression. Knocking down PP2Ac abolished the tumour-promoting role of PDCD10 in the migration, invasion and EMT of HCC. Moreover, a PP2Ac inhibitor (LB100) could restrict tumour growth and metastasis of HCC with high PDCD10 expression. Collectively, PDCD10 promotes EMT and the progression of HCC by interacting with PP2Ac to promote YAP activation, which provides new insight into the mechanism of cancer metastasis. PDCD10 may be a potential prognostic biomarker and therapeutic target for HCC.
Is Spatial Super-resolution feasible using overlapping projectors? (2006)

An interesting issue of contemplation amongst researchers working on multi-projector displays is whether spatial superresolution can be achieved by overlapping images from multiple projectors. This paper presents a thorough theoretical analysis to answer this question using signal processing and perturbation theory. Our analysis is supported by results from a simulated overlapping projector display. This analysis shows that achieving spatial super-resolution using overlapping projectors is practically infeasible.
Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections (2007)

Copeptin levels are increased with increasing severity of LRTI namely in patients with CAP and unfavourable outcome. Copeptin levels, as a novel biomarker, might be a useful tool in the risk stratification of patients with LRTI.
Simultaneous measurement of orthogonal components of polarization in a free-space propagating terahertz signal using electro-optic detection (2011)

We report a polarization-sensitive terahertz time-domain spectroscopy system, which allows the simultaneous measurement of orthogonal components of the polarization of a free-space propagating terahertz beam using a dual electro-optic detection scheme. We demonstrate the operation of our system by measuring the birefringence of lithium niobate, simultaneously obtaining terahertz spectra from two orthogonal crystallographic directions.
The Hyperacusis Questionnaire, loudness discomfort levels, and the Hospital Anxiety and Depression Scale (2013)

Objective: The aim of this study was to compare hyperacusis measurement tools often used in audiological practice in order to determine the most valid measure for assessing hyperacusis. Another aim was to examine the mean value for the Hyperacusis Questionnaire (HQ) in this patient group. Design: This was a cross-sectional study to compare the HQ with loudness discomfort levels (LDL), the Hospital Anxiety and Depression Scale (HADS), and items from a clinical interview dealing with hyperacusis symptoms. Sixty-two patients between the ages of 18 and 61 years were evaluated. All patients were diagnosed with hyperacusis. Results: There were significant negative correlations between the HQ and nearly all LDL scores for the right ear, but no significant correlations could be found for the left ear. LDLs were significantly correlated with the anxiety subscale of the HADS while there were no significant correlations between the HQ and either of the HADS scales. Of the 62 patients, 41 scored above and 21 scored below the previously recommended cut-off for the HQ. Conclusion: We suggest that clinicians should use the HQ and HADS in combination with a clinical interview to diagnose hyperacusis, and propose that the cut-off for the Swedish version of the HQ should be lowered.
OXA beta-lactamase-mediated carbapenem resistance in Acinetobacter baumannii (2011)

blaOXA-23 like and bla OXA 51 like genes are the most common types of OXA carbapenamases while the blaVIM type is the most common type of metallo-beta-lactamase contributing to carbapenem resistance in clinical isolates of A. baumannii. The coproduction of OXA and metallo-beta-lactamases is not an uncommon phenomenon in A. baumannii.
A systematic review for evidence of efficacy of anticholinergic drugs to treat drooling (2003)

Drooling frequently occurs in children with multiple handicaps; application of anticholinergic drugs is a potential strategy to treat drooling. A computer aided search of original studies concerning the treatment of drooling was carried out. The methodological and statistical integrity of the identified studies were assessed with previously defined criteria. The articles were weighed for their separate contribution to the evidence. The search resulted in 64 reports, of which seven studies passed the screening and were subjected to further assessment and discussion by three referees. Because of the small number of reports and the methodological restriction within the studies, no meta-analysis could be performed. No general conclusion could be made about the efficacy of anticholinergic drugs in treatment of drooling in children with multiple handicaps. There was some evidence that three anticholinergic drugs (benztropine, glycopyrrolate, and benzhexol hydrochloride) are effective in the treatment of drooling, but it could not be concluded that one drug is preferable.
Going International: Double/Joint Degree Programs in a Taiwanese University (2012)

In their pursuit of international competitiveness and reputation, many universities have been internationalizing their campuses through a wide range of initiatives. One popular cooperative platform is double/joint degree programs (DJDP), where providers in different countries collaborate to offer a program. Despite the increased popularity of such programs, few studies have concentrated on them in relation to internationalization. In this wider context the current article used a case study approach to examine DJDP at a private university in Taiwan. In addition to better understanding how these programs are run, some critical issues and challenges emerged, including student mobility, program design, quality assurance and academic alignment, language use and domination, organizational restructuring, professional capacity enhancement, and employment. These discussions deepen existing knowledge about DJDP.
Plasma p-tau217: from ‘new kid’ to most promising candidate for Alzheimer’s disease blood test (2020)

This scientific commentary refers to ‘Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease’, by Mattsson-Carlgren et al. (doi:10.1093/brain/awaa286).
Impact of node-selfishness on the connectivity and path delay of Ad-hoc networks (2012)

We investigate the impact of the node-selfishness on the network connectivity and the path delay of information dissemination in large scale Ad-hoc networks based on the percolation theory. A network framework with links obeying stationary process is conceived by combining the effects of both node-selfishness and link qualities. The existence of the node cooperation probability boundary is proved when the network density exceeds a value. The network presents two connection characteristics with respect to this boundary. The minimum path delay is asymptotically independent of the source-destination distance when the node cooperation probability exceeds this boundary. While the node cooperation probability is below the boundary, the minimum path delay scales linearly with the source-destination distance. Simulation results verify the theoretical analysis.
Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor (2011)

Nucleotide pyrophosphatases/phosphodiesterases (NPPs) are ubiquitous membrane-associated or secreted ectoenzymes that have a role in regulating extracellular nucleotide and phospholipid metabolism. Among the members of the NPP family, NPP1 and -3 act on nucleotides such as ATP, while NPP2, -6, and -7 act on phospholipids such as lysophosphatidylcholine and sphingomyelin. NPP6, a recently characterized NPP family member, is a choline-specific glycerophosphodiester phosphodiesterase, but its functions remain to be analyzed, partly due to the lack of highly sensitive activity assay systems and practical inhibitors. Here we report synthesis of novel NPP6 fluorescence probes, TG-mPC and its analogues TG-mPC(3)C, TG-mPC(5)C, TG-mPENE, TG-mPEA, TG-mPhos, TG-mPA, TG-mPMe, and TG-mPPr. Among the seven NPPs, only NPP6 hydrolyzed TG-mPC, TG-mPC(3)C, and TG-mPENE. TG-mPC was hydrolyzed in the cell lysate from NPP6-transfected cells, but not control cells, showing that it is suitable for use in cell-based NPP6 assays. We also examined the usefulness of TG-mPC as a fluorescence imaging probe. We further applied TG-mPC to carry out high-throughput NPP6 inhibitor screening and found several NPP6-selective inhibitors in a library of about 80,000 compounds. Through structure-activity relationship (SAR) analysis, we identified a potent and selective NPP6 inhibitor with an IC(50) value of 0.21 μM. Our NPP6-selective fluorescence probe, TG-mPC, and the inhibitor are expected to be useful to elucidate the biological function of NPP6.
Effective Gelation-Delaying Additives for Cr+3/Polymer Gels (1993)

ABSTRACT A coordination chemical approach for delaying the gelation of Cr+3/polymer compositions has been explored. By screening organic ligands for their gelation delaying power with hydrated Cr+3/polymer and Cr(OAc)3/polymer solutions several powerful retarding ligands have been identified. Use of the pre-formed Cr+3 complexes of these ligands together with additional, uncomplexed ligand in the gelant solution provides outstanding control over the gelation time over the temperature range 60°-135°C. With these compositions gelation times spanning the range from several hours to one month or more have been obtained at temperatures up to 120°C; such gelation delays should be suitable for a number of near-well and in-depth gel treatments. In virtue of the low toxicity of Cr+3 and its complexes, the potential environmental impact of the new gelation compositions is notably reduced relative to those employing Cr+6 or formaldehyde. A number of variables have been evaluated for their influence on the gelation delay, and preliminary experimental results on the propagation of Cr+3 in porous media at high temperature are reported. Our current mechanistic understanding of the gelation delay chemistry is also described.
Analysis of Buildup Tests With Short Producing Time (1986)

Summary Pressure buildup data with short producing time are often difficult to analyze. Although the semilog method, known as the Horner1 method, can be used, the drawdown type curve should not. Thus it is difficult to determine whether the semilog plot actually includes the correct straight line. In this paper, a new log-log graph specially designed for a pressure buildup test with short producing time is suggested. This graph allows the user to determine easily the type of flow regime (linear, bilinear, or radial). Consequently, it can be used to detect the presence of the correct semilog straight line. The new graph can also be used to calculate the formation permeability or fracture conductivity in a fashion similar to the semilog method. The analytical models used to develop the new technique are presented. The models consider both well-bore storage and skin effect. A field example is presented and discussed. Use of the new technique to analyze a buildup test with short producing time is presented and briefly compared with the existing techniques.
Feedback-driven result ranking and query refinement for exploring semi-structured data collections (2010)

Feedback process has been used extensively in document-centric applications, such as text retrieval and multimedia retrieval. Recently, there have been efforts to apply feedback to semi-structured XML document collections as well. In this paper, we note that feedback can also be an effective tool for exploring (through result ranking and query refinement) large semi-structured data collections. In particular, in large scale data sharing and curation environments, where the user may not know the structure of the data, queries may initially be overly vague. Given a path query and a set of results identified by the system to this query over the data, we consider two types of feedback: Soft feedback captures the user's preference for some features over the others. Hard feedback, on the other hand, expresses users' assertions regarding whether certain features should be further enforced or, in contrast, are to be avoided. Both soft and hard feedback can be "positive" or "negative". For soft feedback, we develop a probabilistic feature significance measure and describe how to use this for ranking results in the presence of dependencies between the path features. To deal with the hard feedback efficiently (i.e., fast enough for interactive exploration), we present finite automata based query refinement solutions. In particular, we present a novel LazyDFA+ algorithm for managing hard feedback. We also describe optimizations that leverage the inherently iterative nature of the feedback process. We bring together these techniques in AXP, a system for adaptive and exploratory path retrieval. The experimental results show the effectiveness of the proposed techniques.
Ultraviolet‐B‐induced responses in <i>Arabidopsis thaliana</i>: role of salicylic acid and reactive oxygen species in the regulation of transcripts encoding photosynthetic and acidic pathogenesis‐related proteins (1998)

Supplementary UV‐B was shown to lead to a decrease in transcripts encoding the photosynthetic genes Lhcb and psbA and a concomitant increase in transcripts encoding three acid‐type pathogenesis‐related proteins, PR‐1, PR‐2 and PR‐5, in Arabidopsis thaliana . UV‐B radiation has been reported to lead to the generation of reactive oxygen species (ROS). Here we report that ROS are required for UV‐B‐induced down‐regulation of the photosynthetic genes and up‐regulation of PR genes, as the addition of antioxidants before UV‐B treatment resulted in a marked reduction in the effect of UV‐B on both sets of genes. Rises in ROS are frequently accompanied by increases in salicylic acid (SA) accumulation. UV‐B treatment of transgenic NahG Arabidopsis plants, which are unable to accumulate SA, showed that the increase in PR transcripts, but not the decrease in photosynthetic transcripts, was dependent on the increase in SA. In addition, a 3 d exposure to UV‐B radiation resulted in a 7‐fold increase in SA levels. Oxidant treatment of NahG plants indicated that ROS could not up‐regulate PR genes in the absence of SA accumulation; however, the down‐regulation of photosynthetic transcripts was unchanged from that in wild‐type plants. The results indicate that the effects of UV‐B on the two sets of genes are mediated through two distinct signal tranduction pathways. One pathway is ROS‐dependent but SA‐independent and mediates the down‐regulation of photosynthetic genes. The other is SA‐ and ROS‐dependent and mediates the up‐regulation of the acidic‐type PR genes.
Stochastic approximation algorithms for constrained optimization via simulation (2011)

We develop four algorithms for simulation-based optimization under multiple inequality constraints. Both the cost and the constraint functions are considered to be long-run averages of certain state-dependent single-stage functions. We pose the problem in the simulation optimization framework by using the Lagrange multiplier method. Two of our algorithms estimate only the gradient of the Lagrangian, while the other two estimate both the gradient and the Hessian of it. In the process, we also develop various new estimators for the gradient and Hessian. All our algorithms use two simulations each. Two of these algorithms are based on the smoothed functional (SF) technique, while the other two are based on the simultaneous perturbation stochastic approximation (SPSA) method. We prove the convergence of our algorithms and show numerical experiments on a setting involving an open Jackson network. The Newton-based SF algorithm is seen to show the best overall performance.
Factor IXa and von Willebrand factor modify the inactivation of factor VIII by activated protein C. (1990)

Activated protein C inactivates factor VIII by proteolytic cleavage of the heavy chain of factor VIII. Protein S and calcium ions are cofactors in this reaction. We have examined the effects of several potential modulators of this reaction, including phospholipids, von Willebrand factor, and factor IXa, all of which bind factor VIII. Our results indicate that neither resting nor stimulated platelets nor phospholipid vesicles protect factor VIII from inactivation by activated protein C in either the presence or the absence of protein S. However, the addition of von Willebrand factor decreases the inactivation of factor VIII by activated protein C by 20% to 30%, and factor IXa, which is known to protect factor VIII from inactivation by activated protein C, confers additional protection with von Willebrand factor. The active site of factor IXa is necessary for the protective effect, because native factor IX and active site-inhibited factor IXa do not protect factor VIII from inactivation. Thus there is an additive protective effect when von Willebrand factor and factor IXa are present with factor VIII, leading to a decrease in the inactivation by activated protein C. These factors may be particularly important in stabilizing factor VIII in the circulation and during the early stages of coagulation.
Clinical Tests for the Musculoskeletal System (2008)

Clinical tests for the musculoskeletal system : , Clinical tests for the musculoskeletal system : , کتابخانه دیجیتال جندی شاپور اهواز