gebhart/patrepeval huggingface dataset:
Randomized Controlled Study of an Intravitreous Dexamethasone Drug Delivery System in Patients With Persistent Macular Edema (2007)

In persistent macular edema, a single dexamethasone DDS treatment produced statistically significant BCVA improvements 90 days after treatment and was well tolerated for 180 days. Application to Clinical Practice Dexamethasone DDS, 700 microg, may have potential as a treatment for persistent macular edema.
Drug design from the cryptic inhibitor envelope (2016)

Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design. Here we show by nuclear magnetic resonance spectroscopy that inhibitors of LpxC--an essential enzyme of the lipid A biosynthetic pathway in Gram-negative bacteria and a validated novel antibiotic target--access alternative, minor population states in solution in addition to the ligand conformation observed in crystal structures. These conformations collectively delineate an inhibitor envelope that is invisible to crystallography, but is dynamically accessible by small molecules in solution. Drug design exploiting such a hidden inhibitor envelope has led to the development of potent antibiotics with inhibition constants in the single-digit picomolar range. The principle of the cryptic inhibitor envelope approach may be broadly applicable to other lead optimization campaigns to yield improved therapeutics.
Anode-supported solid oxide fuel cells with ion conductor infiltration (2011)

Nano ion conductor infiltration to anode andcathode side of solid oxide fuel cell (SOFC) significantly improves the performance of an SOFC. The effects of processing parameters such as molar concentration, sintering temperature and holding time are investigated. The performance of fuel cell is evaluated with a test station and an impedance analyzer. The SEM investigation showed that a nano ion conductor phase forms around the main phase in the anode and the cathode. The results showed that nano infiltration enhances significantly the performance of SOFC. The power density is found to increase around two times with infiltration. It is also found that the particle size and the porosity significantly affect the performance of infiltrated SOFC cell. While smaller infiltrated grains enhance the performance lower porosity adversely affects the performance. Copyright © 2011 John Wiley & Sons, Ltd.
Polar codes for NAND-based SSD systems: A joint source channel coding perspective (2017)

Polar codes [1] are a class of provably capacity-achieving error correcting codes (ECC) for memoryless symmetric channels with low-complexity code structures; they have been shown to enjoy better decoding performance over LDPC and Turbo codes under certain scenarios. In this work, we study the application of polar codes for NAND-based SSDs, and mainly focus on the joint source channel coding (JSCC) aspect of polar codes for flash data protection. In a practical SSD system, in addition to the host data, both flash translation layer (FTL) and host side will write on NAND a small amount of non-host data (a.k.a. metadata) for system managing purposes. We demonstrate that the metadata information can be readily and efficiently utilized by polar codes, whereas such property is lacking in LDPC-based systems. With the help of the side information provided by metadata, the decoding capability of polar codes can be further enhanced with little or no modifications on the decoder side. Simulation results verify the performance improvement of metadata-based JSCC scheme, and indicate that polar codes have competitive advantages over LDPC codes on flash memories.
Preparation of synthetic polypeptide domains of carcinoembryonic antigen and their use in epitope mapping. (1991)

Genes encoding the four principal polypeptide domains (N, A1-B1, A2-B2, and A3-B3) of carcinoembryonic antigen (CEA) were synthesized and expressed in Escherichia coli as fusion products with bacterial CMP-KDO synthetase (CKS). The four synthetic fusion proteins were purified in high yield and used as targets in Western blots for 11 anti-CEA MAbs and to compete with immobilized CEA for binding to four of these MAbs. Each of the MAbs showed strong binding to one or more of the fusion proteins. In Western blots, MAbs H19C91 and 4230 bound only to CKS-N. MAbs H8C2 and H11C35 bound only CKS-A1-B1, and MAbs T84.66, H46C136, and H21C83 appeared to be specific for CKS-A3-B3. None of the MAbs tested bound only to CKS-A2-B2. However, two MAbs bound both CKS-A1-B1 and CKS-A3-B3 and one MAb (3519) bound to all three of the repeated domains. Since these three domains exhibit over 90% amino acid sequence homology, the latter results were not surprising. The competition studies largely confirmed the results of Western blots but did show some MAb-fusion protein interactions not observed in Western blots. These competition studies also allowed estimation of the relative affinities of the MAbs for the synthetic domains and for native CEA. These studies demonstrated that epitopes in CEA recognized by the MAbs in this study are peptide in nature and that the fusion proteins are of utility in the localization of the epitopes on the polypeptide chain of CEA.
A review of the geology and structure of the Cheyenne belt and Proterozoic rocks of southern Wyoming (1989)

The Colorado Proterozoic province is separated from Archean rocks of the Wyoming province by a major structural boundary, the Cheyenne belt. Proterozoic rocks south of the Cheyenne belt are exposed in the Sierra Madre, Medicine Bow Mountains, and Laramie Range of southern Wyoming. They consist of metavolcanic units, metagraywacke, pelitic schist and gneiss, amphibolite, and felsic to mafic intrusive rocks that locally resemble rocks of central Colorado. North of the Cheyenne belt, Archean granite and gneiss of the Wyoming craton are overlain by a Late Archean and Early Proterozoic supracrustal sequence that contains quartzite, metadolomite, phyllite, and subordinate metavolcanic rocks. The eugeoclinal character of the metamorphic rocks south of the Cheyenne belt contrasts sharply with the dominantly siliciclastic supracrustal rocks north of the Cheyenne belt. Although specific sequences south of the belt have not yet been correlated between the Sierra Madre, Medicine Bow Mountains, and Laramie Range, similarities in age, lithology, and major element chemistry suggest that they are part of a single geologic terrane. Macroscopic structure and microscopic kinematic indicators within the Cheyenne belt suggest that accretion of the Proterozoic rocks of northern Colorado to the Archean Wyoming craton was accomplished primarily by large-scale thrusting. Following accretion of individual thrust blocks, the boundary zone was steepened by folding and reactivated locally during a period of strike-slip movement. Presence of similar lithologies and shear zones south of the Cheyenne belt suggests that the southern margin of the Wyoming craton may have been a long-lived zone of crustal accretion.
Chemosensitivity of human melanoma xenografts in immunocompetent mice and its histological evaluation (1984)

In the subrenal capsule assay, the immuno-competent mice used have a host immune response to the graft which may introduce a bias in the determination of tumour size. A study was therefore conducted to verify the quality of the correlation that could exist between "macroscopical" and "microscopical" evaluation. A histological study of 12 different tumours treated with cis-Pt, L-PAM, DTIC, vindesine, BCNU or TGU demonstrated that a cellular host immune response was observed in 11 out of the 12 control groups and was uneven in the treated groups. The "microscopical" and "macroscopical" evaluations of tumour-take were 100 and 95% respectively. Although there was a fair correlation between the "microscopic" and "macroscopic" parameters, tumour variations in absence of host reaction--which reflect pure chemosensitivity of the treated tissue--could be measured in 50% of the cases. It was possible to determine a base-line for rejection of the test results when the control group showed a decrease in mean tumour size exceeding 20% of its initial size on day 0. If the decrease is less than 20%, then the histological evaluation appears to be of considerable additional value.
New Derivatives of Amino Acids N, N-Dichloroglycine and N, N-Dichloro-B-Alanine (1976)

Abstract The chlorinated derivatives of amino acids are important from both a biological and chemical point of view. Hitherto all references to the N-chlorinated derivatives of amino acids involve reaction of the amino acid and sodium hypochlorite at various pH's1-8. Due to the instability and high water solubility of the N-chlorinated amino acids isolation has not yet been reported.
Registration of <formula formulatype="inline"><tex Notation="TeX">$3{\rm D}+{\rm t}$</tex></formula> Coronary CTA and Monoplane <formula formulatype="inline"><tex Notation="TeX">$2{\rm D}+{\rm t}$</tex></formula> X-Ray Angiography (2013)

A method for registering preoperative 3D+t coronary CTA with intraoperative monoplane 2D+t X-ray angiography images is proposed to improve image guidance during minimally invasive coronary interventions. The method uses a patient-specific dynamic coronary model, which is derived from the CTA scan by centerline extraction and motion estimation. The dynamic coronary model is registered with the 2D+t X-ray sequence, considering multiple X-ray time points concurrently, while taking breathing induced motion into account. Evaluation was performed on 26 datasets of 17 patients by comparing projected model centerlines with manually annotated centerlines in the X-ray images. The proposed 3D+t/2D+t registration method performed better than a 3D/2D registration method with respect to the accuracy and especially the robustness of the registration. Registration with a median error of 1.47 mm was achieved.
From Vegetable Oils to Polyurethanes: Synthetic Routes to Polyols and Main Industrial Products (2012)

Most of biobased polyols for polyurethanes are synthesized from vegetable oils. In the first part, the present review goes into details of these different synthetic routes to obtain polyols. First, olefinic functionalities of triglycerides could easily be epoxidized, leading to reactive epoxide groups. Second, triglycerides double bonds could undergo a wide ranges of reactions to yield polyols. Finally, the carbonyl group could also be used as a reactive group to yield various polyols. In the second part, the present review is dedicated to the commercial biobased polyols, and, based on the patent literature focuses on the industrial synthetic routes.
Syndecan-4 Modulates Focal Adhesion Kinase Phosphorylation (2002)

The cell-surface heparan sulfate proteoglycan syndecan-4 acts in conjunction with the alpha(5)beta(1) integrin to promote the formation of actin stress fibers and focal adhesions in fibronectin (FN)-adherent cells. Fibroblasts seeded onto the cell-binding domain (CBD) fragment of FN attach but do not fully spread or form focal adhesions. Activation of Rho, with lysophosphatidic acid (LPA), or protein kinase C, using the phorbol ester phorbol 12-myristate 13-acetate, or clustering of syndecan-4 with antibodies directed against its extracellular domain will stimulate formation of focal adhesions and stress fibers in CBD-adherent fibroblasts. The distinct morphological differences between the cells adherent to the CBD and to full-length FN suggest that syndecan-4 may influence the organization of the focal adhesion or the activation state of the proteins that comprise it. FN-null fibroblasts (which express syndecan-4) exhibit reduced phosphorylation of focal adhesion kinase (FAK) tyrosine 397 (Tyr(397)) when adherent to CBD compared with FN-adherent cells. Treating the CBD-adherent fibroblasts with LPA, to activate Rho, or the tyrosine phosphatase inhibitor sodium vanadate increased the level of phosphorylation of Tyr(397) to match that of cells plated on FN. Treatment of the fibroblasts with PMA did not elicit such an effect. To confirm that this regulatory pathway includes syndecan-4 specifically, we examined fibroblasts derived from syndecan-4-null mice. The phosphorylation levels of FAK Tyr(397) were lower in FN-adherent syndecan-4-null fibroblasts compared with syndecan-4-wild type and these levels were rescued by the addition of LPA or re-expression of syndecan-4. These data indicate that syndecan-4 ligation regulates the phosphorylation of FAK Tyr(397) and that this mechanism is dependent on Rho but not protein kinase C activation. In addition, the data suggest that this pathway includes the negative regulation of a protein-tyrosine phosphatase. Our results implicate syndecan-4 activation in a direct role in focal adhesion regulation.
Noise compensation algorithms for use with hidden Markov model based speech recognition (2003)

A preliminary theoretical and experimental examination is made of three noise compensation techniques. The three techniques are those due to: Klatt (1976); Bridle et al (1984); and Holmes & Sedgwick (1986). The first two of these techniques have been re-interpreted for use within a hidden Markov model based recogniser. A description is given of how this was done, together with a discussion on some implementation considerations. Experimental results are given for the performance of the algorithms at various signal-to-noise ratios. The principles of recognition in noise are discussed from an implementation point of view and it is shown how the three techniques can be viewed as variations on a single theme.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rapid Assay Format for Multiplex Detection of Humoral Immune Responses to Infectious Disease Pathogens (HIV, HCV, and TB) (2007)

A novel assay is described for multiplex detection of antibodies against different pathogens from a single sample. The assay employs a modified lateral flow format (consecutive flow, CF) together with a sensitive reporter particle technology (up-converting phosphor technology, UPT) that allows for fully instrumented assay analysis. Lateral flow (LF) strips developed for the detection of human antibodies against human immunodeficiency virus type-1 and -2 (HIV-1 and -2) with additional capture zones to detect antibodies against Myobacterium tuberculosis (TB) and hepatitis C Virus (HCV) provided the strips to test multiplexing. Data are presented that show the performance of the TB and HCV test, as well as two multiplex assays, TB with HIV and HCV with HIV. The TB/HCV assays demonstrate excellent detection capability, and HIV multiplexing does not affect the qualitative test result. The bench-top CF format was converted to a microfluidic platform and a first prototype semiautomated chip capable of performing CF is presented here.
Generating Steganographic Images via Adversarial Training (2017)

Adversarial training was recently shown to be competitive against supervised learning methods on computer vision tasks, however, studies have mainly been confined to generative tasks such as image synthesis. In this paper, we apply adversarial training techniques to the discriminative task of learning a steganographic algorithm. Steganography is a collection of techniques for concealing information by embedding it within a non-secret medium, such as cover texts or images. We show that adversarial training can produce robust steganographic techniques: our unsupervised training scheme produces a steganographic algorithm that competes with state-of-the-art steganographic techniques, and produces a robust steganalyzer, which performs the discriminative task of deciding if an image contains secret information. We define a game between three parties, Alice, Bob and Eve, in order to simultaneously train both a steganographic algorithm and a steganalyzer. Alice and Bob attempt to communicate a secret message contained within an image, while Eve eavesdrops on their conversation and attempts to determine if secret information is embedded within the image. We represent Alice, Bob and Eve by neural networks, and validate our scheme on two independent image datasets, showing our novel method of studying steganographic problems is surprisingly competitive against established steganographic techniques.
A stable approach for<i>Q</i>-compensated viscoelastic reverse time migration using excitation amplitude imaging condition (2018)

The earth [Formula: see text] filtering causes poor illumination of the subsurface. Compensating for the attenuated amplitude and distorted phase is crucial during elastic reverse time migration (ERTM) to improve the imaging quality. Conventional [Formula: see text]-compensated ERTM ([Formula: see text]-ERTM) methods tend to boost the attenuated energy to inverse the [Formula: see text] effects. These methods usually suffer from severe numerical instability because of the unlimited amplification of the high-frequency noise. Low-pass filtering is generally used to stabilize the process, however, at the expense of precision. We have developed a stable compensation approach in this paper. Based on the decoupled fractional Laplacians viscoelastic wave equation, two compensation operators are obtained by extrapolating wavefield in the dispersion-only and viscoelastic media. Because no explicit amplification is included, these two operators are absolutely stable for implementation. To improve the division morbidity for calculating the compensation operators, we use the excitation amplitude criterion and embed the operators into a vector-based [Formula: see text]-compensated excitation amplitude imaging condition. With the derived imaging condition, we could compensate for the absorption accurately without needing to concern the stability issue. The [Formula: see text]-ERTM results for noise-free data are carried out over a simple layered model and a more realistic Marmousi model with an attenuating area to verify the feasibility of the proposed approach. The migration results for noisy data from the Marmousi model further prove that the proposed method performs better fidelity, adaptability, and antinoise performance compared with conventional compensation method with low-pass filtering.
TRAINING IN VIRTUAL ENVIRONMENTS: A SAFE, COST-EFFECTIVE, AND ENGAGING APPROACH TO TRAINING (2008)

tions also ensures that the instructor can visually verify that the training instructions being generated are complete and no step is missing in the sequence.The work reported in this book was a collaborative effort.Chester Clark, Ralph Pettersen, and Lisa Davie supported this work from NSWC Indian Head, where a laboratory similar to the one at the University of Maryland was created.Cindy Yeager and Darrin Krivitsky gave feedback on the training needs of
Current advances and challenges in CAR T-Cell therapy for solid tumors: tumor-associated antigens and the tumor microenvironment (2023)

The past decade has witnessed ongoing progress in immune therapy to ameliorate human health. As an emerging technique, chimeric antigen receptor (CAR) T-cell therapy has the advantages of specific killing of cancer cells, a high remission rate of cancer-induced symptoms, rapid tumor eradication, and long-lasting tumor immunity, opening a new window for tumor treatment. However, challenges remain in CAR T-cell therapy for solid tumors due to target diversity, tumor heterogeneity, and the complex microenvironment. In this review, we have outlined the development of the CAR T-cell technique, summarized the current advances in tumor-associated antigens (TAAs), and highlighted the importance of tumor-specific antigens (TSAs) or neoantigens for solid tumors. We also addressed the challenge of the TAA binding domain in CARs to overcome off-tumor toxicity. Moreover, we illustrated the dominant tumor microenvironment (TME)-induced challenges and new strategies based on TME-associated antigens (TMAs) for solid tumor CAR T-cell therapy.
Growth and characterization of (111) and (001) oriented MgO films on (001) GaAs (1993)

The effects of substrate preparation on the structure and orientation of MgO films grown on (001) GaAs using pulsed laser deposition has been investigated. Textured MgO films displaying a (111)MgO∥(001)GaAs orientation relation with x-ray rocking curve full width at half maximum (FWHM) values as low as 1.8° were obtained in cases where the native GaAs surface oxide was only partially desorbed prior to growth. Reflection high-energy electron diffraction, transmission electron microscopy (TEM), and x-ray pole figure analysis of these films reveals a preferential orientation within the plane of the substrate: [11̄0]MgO∥[11̄0]GaAs and [112̄]MgO∥[110]GaAs. An interfacial layer (∼5 nm thick) was observed in high resolution TEM analysis, and was attributed to a remnant native GaAs oxide layer. Complete desorption of the native GaAs oxide at ∼600 °C in vacuum prior to MgO growth led to significant surface roughening due to Langmuir evaporation, and resulted in randomly oriented polycrystalline MgO films. Growth of MgO on Sb-passivated GaAs substrates, which provided smooth, reconstructed surfaces when heated to 350 °C in vacuum, resulted in cube-on-cube oriented films [i.e., (001)MgO∥(001)GaAs,[100]MgO∥[100]GaAs] with x-ray rocking curve FWHM values as low as 0.47°. TEM analysis of the cube-on-cube oriented films revealed evidence of localized strain fields at the MgO/GaAs interface, indicating the presence of misfit dislocations in the MgO layer.
Topical Neutralization of Interleukin-17 during Experimental Pseudomonas aeruginosa Corneal Infection Promotes Bacterial Clearance and Reduces Pathology (2012)

The proinflammatory cytokine interleukin-17 (IL-17) is involved in neutrophilic tissue infiltration, contributing to both microbial clearance as well as inflammation-associated tissue damage. Its role during bacterial corneal infections is unknown. We hypothesized that IL-17 responses would be detrimental in this setting and tested the impact of IL-17 receptor deficiency or antibody-mediated neutralization of IL-17 in a murine model of Pseudomonas aeruginosa ulcerative keratitis after scratch injury. We found that, compared with infected corneas from wild-type mice, those from IL-17 receptor (IL-17R)-deficient mice had significantly lower corneal pathology scores, neutrophil influx, and intracellular bacterial levels. Infected IL-17R-deficient corneas had low intercellular adhesion molecule 1 (ICAM-1) expression, and ICAM-1-deficient mice were similarly resistant to infection. Topical treatment with polyclonal antibodies to IL-17 resulted in significant reductions in corneal pathology and also lowered bacterial counts after infection with six different laboratory or clinical P. aeruginosa strains, including both invasive and cytotoxic strains. Thus, neutralization of IL-17 during P. aeruginosa corneal infection reduces neutrophil influx and pathology without compromising bacterial clearance and offers a promising new avenue for therapy of these potentially sight-threatening infections.