gebhart/patrepeval huggingface dataset:
Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates (2017)

Despite useful in vivo activity, no therapeutic against dengue virus (DENV) has demonstrated efficacy in clinical trials. Herein, we explored dosing and virological endpoints to guide the design of human trials of VIS513, a pan-serotype anti-DENV IgG1 antibody, in non-human primates (NHPs). Dosing VIS513 pre- or post-peak viremia in NHPs neutralized infectious DENV although RNAemia remained detectable post-treatment; differential interaction of human IgGs with macaque Fc-gamma receptors may delay clearance of neutralized DENV. Our findings suggest useful antiviral utility of VIS513 and highlight an important consideration when evaluating virological endpoints of trials for anti-DENV biologics.
Prion Protein Prevents Human Breast Carcinoma Cell Line from Tumor Necrosis Factor α-Induced Cell Death (2004)

To define genetic determinants of tumor cell resistance to the cytotoxic action of tumor necrosis factor alpha (TNF), we have applied cDNA microarrays to a human breast carcinoma TNF-sensitive MCF7 cell line and its established TNF-resistant clone. Of a total of 5760 samples of cDNA examined, 3.6% were found to be differentially expressed in TNF-resistant 1001 cells as compared with TNF-sensitive MCF7 cells. On the basis of available literature data, the striking finding is the association of some differentially expressed genes involved in the phosphatidylinositol-3-kinase/Akt signaling pathway. More notably, we found that the PRNP gene coding for the cellular prion protein (PrP(c)), was 17-fold overexpressed in the 1001 cell line as compared with the MCF7 cell line. This differential expression was confirmed at the cell surface by immunostaining that indicated that PrP(c) is overexpressed at both mRNA and protein levels in the TNF-resistant derivative. Using recombinant adenoviruses expressing the human PrP(c,) our data demonstrate that PrP(c) overexpression converted TNF-sensitive MCF7 cells into TNF-resistant cells, at least in part, by a mechanism involving alteration of cytochrome c release from mitochondria and nuclear condensation.
An Elastic Exoskeleton for Assisting Human Running (2009)

This paper presents the design and preliminary evaluation of an elastic lower-body exoskeleton (eExo). Human legs behave in a spring-like fashion while running. We selected a design that relied solely on material elasticity to store and release energy during the stance phase of running. The exoskeleton included a novel knee joint with a cam and a Bowden cable transferring energy to and from a waist-mounted extension spring. We used a friction-lock clutch controlled by hip angle via a pneumatic cylinder to release the cable during swing phase for free movement of the leg. The design also incorporated a composite leaf spring to store and release energy in the distal portion of the exoskeleton about the foot and ankle. Preliminary test data for our target subject showed that his typical leg deflection was 0.11 m with leg stiffness of 16 kN/m while running at 3.0 m/s. We used these values to set the desired stiffness (60±15% of the normal leg stiffness, or 9.6±2.4 kN/m) and deflection (0.11 m) of the exoskeleton. We created simplified multi-body and full finite element quasi-static models to achieve the desired system stiffness and validate our results, respectively. The final design model had an overall stiffness of 7.3 kN/m, which was within the desired range. We fabricated a single-leg prototype of the exo–skeleton that weighed 7.1 kg. We tested the exoskeleton stiffness quasi-statically and found a stiffness of 3.6 kN/m. While running, the exoskeleton provided ∼30% of the total leg stiffness for two subjects. Although the stiffness was lower than desired, the fabricated prototype demonstrated the ability of a quasi-passive exoskeleton to provide a significant portion of an individual’s leg stiffness while running.
The squeaky clean computer lab (1998)

For many universities, the computer lab is a maintenance headache.Eve~day, someone manages tofigure out a way to remove~la, add>l nd o~en leave the system in a completely unusable state!It can tab many hours to constantly correct and update the computers that students use eveWday in the pursuit of their academic goals.Is it possible to setup and maintain such afacilip without resorting to S. W.A.T. tactics and years of intense therapy?This paper outlines the basics ofsetting up a lab with the objective of having the machines be as se~maintaining as possible with rapect to the sofivare.For the Windows machine, use of PC~ist to refresh the hard drive has proved a practical and timaaving venture.For the Macintosh, Rev~ist has been in usefor manyyears with great success.Con~guring these two sofhvarepachges can be a daunting task but it is something that the Lab Manager can learn and become pro~cient with.Using either PC~kt or Rev~ist involves a number of essentialpa~: a server to store the master imagw on, the SOfhVare program itselJ and the disti.bution@[ethat the sofh'are reah as a set of commanh to take orders.from.~e asentiak of the server setup are discussed to get things started.This isfollowed by a section on the two software packages, installation and con~guration and any "helper''pachages that might be usefil.Final&, there is a discussion of the distribution or control lists that both pachges use.
Protein self-assembly via supramolecular strategies (2016)

Proteins, as the elemental basis of living organisms, mostly execute their biological tasks in the form of supramolecular self-assemblies with subtle architectures, dynamic interactions and versatile functionalities. Inspired by the structural harmony and functional beauty of natural protein self-assemblies to fabricate sophisticated yet highly ordered protein superstructures represents an adventure in the pursuit of nature's supreme wisdom. In this review, we focus on building protein self-assembly systems based on supramolecular strategies and classify recent progress by the types of utilized supramolecular driving forces. Especially, the design strategy, structure control and the thermodynamic/kinetic regulation of the self-assemblies, which will in turn provide insights into the natural biological self-assembly mechanism, are highlighted. In addition, recently, this research field is starting to extend its interest beyond constructing complex morphologies towards the potential applications of the self-assembly systems; several attempts to design functional protein complexes are also discussed. As such, we hope that this review will provide a panoramic sketch of the field and draw a roadmap towards the ultimate construction of advanced protein self-assemblies that even can serve as analogues of their natural counterparts.
A parallel genetic algorithm for service restoration in electric power distribution systems (2002)

This paper develops a coarse-gain parallel genetic algorithm for solving a service restoration problem in electric power distribution systems. A power utility performs service restoration in order to restore out-of-service areas at fault. Developing an effective service restoration procedure is a cost-effective approach to improve service reliability and to enhance customer satisfaction. The main objective in service restoration procedure is to restore as much load as possible by transferring de-energized loads via network reconfigurations to other supporting distribution feeders without violating operating and engineering constraints. Details of the parallel genetic algorithm developed in this paper are described. The proposed method is implemented on transputers for parallel computation. The feasibility of the developed algorithm for service restoration is demonstrated on several distribution networks with promising results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electric Device Abnormal Detection Based on IoT and Knowledge Graph (2019)

Abnormal detection is an essential task to the security and stability of power grid networking operation. Besides the status of power grid itself, the environment information is also necessary to the abnormal detection, such as temperature, humidity, dust and etc. Therefore, we apply the Internet of Things (IoT) technology to monitor the real time status of power grid and its related environment. Then a knowledge based method is proposed to find out the reference data for the abnormal detection and signal correlation algorithm is applied to calculate if the given IoT data is abnormal. The experiment results indicate that the proposed method can integrate the data from multiple resources and perform an accuracy analysis of the abnormality of the given IoT data. The overall accuracy improves from 64% with tradition threshold based method to 92% according to the test dataset.
Road Boundary Detection and Tracking using monochrome camera images (2013)

In this paper a method for Road Boundary Detection and Tracking on monochrome camera images is presented. Using this approach, it is possible to recognize road boundaries in areas without lane markings. To describe the shape of the boundary a clothoid road model is used. The parameters of this model are estimated and tracked by a Particle Filter. The implemented Particle Filter is based on the well known Condensation Algorithm. Only texture features are used for road recognition. For evaluation of these features a patch-based classifier is used. Based on a set of sequences the probability distribution of the classifier output is empirically determined. So the single patches can be assigned to “road” or “non-road” class with a certain probability. The presented algorithm shows good performance with reliable results on a variety of recorded video sequences.
Adaptive microseismic noise estimation and denoising (2016)

Microseismic data recorded by surface arrays are often strongly contaminated by unwanted random noise. This background noise makes the detection of small magnitude events difficult. A noise level estimation and random-noise reduction algorithm is presented for microseismic data analysis based upon minimally controlled recursive averaging and neighborhood shrinkage estimators. The method is fast and data-driven. Results from application of this algorithm to synthetic and real seismic data show that it holds great promise for improving microseismic detection. Presentation Date: Wednesday, October 19, 2016 Start Time: 8:00:00 AM Location: 148 Presentation Type: ORAL
Performance improvements of photonic lantern based coherent receivers (2014)

In this work, the signal-to-noise ratio improvement of photonic lantern-based coherent receivers over single-mode coherent receivers is demonstrated. The signal-to-noise ratio is improved by a factor of 2.8 when other parameters kept constant.
A novel grid interface for photovoltaic, wind-electric, and fuel-cell systems with a controllable power factor of operation (2002)

This paper presents a novel control for a grid interface, for interconnection of renewable energy sources with a three-phase utility, with a controllable power factor of operation. The total harmonic distortion in the line currents meets the 5% limit recommended by the IEEE 519-1992. The novel control strategy for operating the interface at unity or even slightly leading power factor is described and the simulation results are presented. The grid interface described is based on a novel topology for transferring power from the DC side to the three-phase AC system. It consists of a thyristor inverter where the firing angle can be kept at a constant value. The power flow from the DC source to the utility is controlled by two stepdown DC-DC converters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Noninvasive acoustic manipulation of objects in a living body (2020)

In certain medical applications, transmitting an ultrasound beam through the skin to manipulate a solid object within the human body would be beneficial. Such applications include, for example, controlling an ingestible camera or expelling a kidney stone. In this paper, ultrasound beams of specific shapes were designed by numerical modeling and produced using a phased array. These beams were shown to levitate and electronically steer solid objects (3-mm-diameter glass spheres), along preprogrammed paths, in a water bath, and in the urinary bladders of live pigs. Deviation from the intended path was on average <10%. No injury was found on the bladder wall or intervening tissue.
Shopping Path Analysis and Transaction Mining Based on RFID Technology (2007)

The RFID technology is gaining strong support from business for various applications such as supply chain management, access control, airline luggage management, etc. Due to the cost consideration, it is still not a replacement for the traditional item-level bar code. Therefore, tracking and analyzing the shopping paths and purchasing behaviors of customers in a superstore such as Wal-Mart is still a challenging task. In this paper, we propose a RFID deployment model for collecting shopping paths and purchased items of customers. Algorithms based on customer access matrix (CAM) and customer transaction mining (CTM) are then proposed for mining preferred shopping paths and their relationships to the purchased items. In the experiments, we build a dataset generator for generating shopping paths and purchased items of customers, and the results show that our model is applicable to real applications.
A Systematic Capture and Replay Strategy for Testing Complex GUI Based Java Applications (2010)

In this paper we propose a testing strategy that targets Java applications with complex GUI structure and event interactions. We present a capture and replay testing technique which can be employed for different testing purposes: GUI convergence, functional testing and regression testing. The proposed strategy drastically improves, and from different aspects, on standard capture and replay tools. This is done by combining both a model based testing approach with the capture and replay approach and by implementing different automated test oracles. We first model the behavior of the system from the functional specifications or from a trusted version of the system. Tests are then derived from this model to exercise the system in order to ensure correct functional behavior and to cover goal oriented interactions. The case study applies the test strategy on a role-based, multi-user computer game to demonstrate the usefulness and importance of this approach.
Paclitaxel With Inhibitor of Apoptosis Antagonist, LCL161, for Localized Triple-Negative Breast Cancer, Prospectively Stratified by Gene Signature in a Biomarker-Driven Neoadjuvant Trial (2018)

This neoadjuvant trial provides evidence supporting a biomarker-driven targeted therapy approach for selected patients with GS-positive TNBC and demonstrates the utility of a neoadjuvant trial for biomarker validation and drug development, but also highlights toxicity risk. Future neoadjuvant clinical trials should carefully weigh these considerations for targeted therapy development in biomarker-defined TNBC.
Preliminary Toxicity Profile of Arotinoids SMR-2 and SMR-6 in Male B6D2F1 Mice (1987)

Preliminary Toxicity Profile of Arotinoids SMR-2 and SMR-6 in Male B6D2F1 Mice. LINDA-MOOD, C, III, GILES, H. D., AND HILL, D. L. (1987). Fundam. Appl. Toxicol. 8, 517–530. Arotinoids, which are analogs of retinoic acid (RA) and retinol (RO) with the carbon skeleton in a rigid conformation, have more favorable therapeutic indices relative to all-transRA and al-trans-RO. The purpose of this investigation was to obtain preliminary in vivo toxicity data on SMR-2 (analog of RO) and SMR-6 (analog of RA), arotinoids with promising activity (ED50's of 20 × 10−11 and 5 × 10−11 m, respectively; ED50 of RA = 1 × 10−11 m) for reversal of keratinization in tracheal organ culture. A preliminary toxicity study was conducted in male B6D2F1 mice with gavage of retinoids in corn oil (0.01, 0.05, and 0.1 mg/kg/day of SMR-2 or SMR-6; 1, 5, and 10 mg/kg/day of RA as reference control). Due to lack of toxicity, each dose level for SMR-2 and SMR-6 was increased by 4-fold on Day 29 of dosing. The study was terminated on Day 57. Hypervitaminosis A (weight loss, alopecia, skin scaling, and bone thinning) was induced in the mid- and high-dose SMR groups; weight-gain depression was predominant in the high-dose RA group. The SMR compounds were approximately 100-fold more toxic, based on weight loss, than RA. In the SMR dose groups with hypervitaminosis A, white blood cell counts were elevated 2- to 4-fold; and there were microscopic lesions in skin, testes, epididymis, bone, thymus, bone marrow, peripheral lymph nodes, spleen, stomach, adrenal, and pituitary. The leuko-cytosis was attributed to leukopoiesis in spleen and bone marrow, which may be due to either a direct effect and/or a secondary response to a subacute inflammatory reaction in skin. Only peripheral lymph node hyperplasia was observed in SMR-2 and RA low-dose groups. Enlarged thymus, lymph node hyperplasia, leukopoiesis in spleen and bone marrow, elevated alkaline phosphatase with bone hypertrophy, and testicular degeneration were observed in the mid-dose RA group. The results indicate that immune stimulation may be a primary early response to retinoids and that skin, leukopoietic tissues, reproductive organs, stomach, and bone are primary targets for retinoid toxicity.
Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. (1993)

The obese hyperglycaemic ob/ob mouse exhibits hyperphagia and other abnormalities of hypothalamic function. We measured hypothalamic concentrations of four peptides implicated in the control of appetite and energy expenditure, neuropeptide-Y (NPY), neurotensin, galanin, and somatostatin, by RIA and their respective mRNAs using semiquantitative Northern blotting. Using lean (+/+) mice as controls, we found unchanged concentrations of NPY, galanin, and somatostatin and a 25% reduction in neurotensin (P < 0.01). Neurotensin mRNA was similarly decreased (by 30%; P < 0.02), while NPY mRNA was increased 3-fold (P < 0.01). Centrally administered neurotensin decreases food intake, whereas NPY potently stimulates food intake. An increase in NPY gene expression together with reductions in neurotensin concentration and mRNA in the hypothalamus may be implicated in the development of hyperphagia and other neuroendocrine abnormalities seen in the ob/ob mouse.
Atomic Force Microscopy Imaging of Double Stranded DNA and RNA (1992)

A procedure for imaging long DNA and double stranded RNA (dsRNA) molecules using Atomic Force Microscopy (AFM) is described. Stable binding of double stranded DNA molecules to the flat mica surface is achieved by chemical modification of freshly cleaved mica under mild conditions with 3-aminopropyltriethoxy silane. We have obtained striking images of intact lambda DNA, Hind III restriction fragments of lambda DNA and dsRNA from reovirus. These images are stable under repeated scanning and measured contour lengths are accurate to within a few percent. This procedure leads to strong DNA attachment, allowing imaging under water. The widths of the DNA images lie in the range of 20 to 80nm for data obtained in air with commercially available probes. The work demonstrates that AFM is now a routine tool for simple measurements such as a length distribution. Improvement of substrate and sample preparation methods are needed to achieve yet higher resolution.
Optimization of femtocell network configuration under interference constraints (2009)

Femto BS (base station) is emerging as a key technology to secure the coverage and capacity in indoor environments. However, since the existing macrocell network is overlaid on femtocell networks utilizing the same set of frequency channels, femtocell networks can originate severe co-channel interference to the macrocell network unless the femtocell network is carefully configured. Therefore, according to a desired network-wide objective, we optimize the femtocell network with constraints such that the service connectivity with a femto BS is secured in the target indoor area while the signal emitted out of the building, playing as interference to the outdoor users, should be controlled with an appropriate strength in order not to interrupt the communication between macro BS and outdoor users. Each optimization problem is formulated as a mixed integer programming, and as the results, we obtain not only the transmit power and operational frequency channel of each femto BS, but also the optimal femto BS-to-user association pair at each geographical position.
Calixarene-Doped Polyaniline for Applications in Sensing (2006)

Synthesis of a new type of calixarene-doped polyaniline (PANI) is reported. Polyaniline as a free base (emeraldine) was synthesized by a chemical method, in the presence of HCl and ammonium peroxodisulphate as oxidant. PANI was doped with p-sulfonatocalix|4|arene. The structure of the protonic acid doped- PANI was investigated by infrared and UV-VIS spectroscopies. The spectral features of dopant are found in the doped polyaniline. The synthesized polyaniline exhibits enhanced solubility in dimethyl for mamide and N-methyl pyrrolidon, which is useful for sensing
On the mechanism of metal colloid catalyzed hydrosilylation: proposed explanations for electronic effects and oxygen cocatalysis (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the mechanism of metal colloid catalyzed hydrosilylation: proposed explanations for electronic effects and oxygen cocatalysisLarry N. LewisCite this: J. Am. Chem. Soc. 1990, 112, 16, 5998–6004Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/ja00172a014https://doi.org/10.1021/ja00172a014research-articleACS PublicationsRequest reuse permissionsArticle Views1901Altmetric-Citations232LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Uptake Kinetics of Cell-Penetrating Peptides (2010)

As our knowledge increases about the diversity in uptake mechanisms displayed by cell-penetrating peptides (CPP), the concept of CPP uptake kinetics becomes increasingly complex. Here, we present three different assays that can be used for studying different kinetic aspects of CPP-mediated delivery: intracellular accumulation and membranolytical effects, intracellular CPP-cargo detachment, and finally a functional readout of a biological action from the delivered cargo. Unlike the traditional end-point measurements that give a static postincubation readout, these assays are all dynamic, real-time, in situ measurements obtained during incubation. A combination of some (or all) of these different assays gives us not only interesting kinetic information about the uptake routes but also provides a simple and valuable methodology for the evaluation of potential drug candidates based on the chemical modification of CPPs by cargo attachment.