gebhart/patrepeval huggingface dataset:
ChemInform Abstract: THE STRUCTURE OF “DIFORMAZYL”:5‐(BIS(PHENYLAZO)METHYLENE)‐1,3‐DIPHENYLTETRAZOLINE BETAINE (1979)

Abstract Das aus Lävulinsäure oder 4‐Oxo‐heptan‐l ,7‐disäure oder Dioxobernsteinsäure‐bis‐phenylhydrazon mit jeweils Benzoldiazoniumhydroxid darstellbare "Diformazyl" wurde um die Jahrhundertwende als Biformazan (I) formuliert.
Software Defined Monitoring of Application Protocols (2015)

With the ongoing shift of network services to the application layer also the monitoring systems focus more on the data from the application layer. The increasing speed of the network links, together with the increased complexity of application protocol processing, require a new way of hardware acceleration. We propose a new concept of hardware acceleration for flexible flow-based application level traffic monitoring which we call Software Defined Monitoring. Application layer processing is performed by monitoring tasks implemented in the software in conjunction with a configurable hardware accelerator. The accelerator is a high-speed application-specific processor tailored to stateful flow processing. The software monitoring tasks control the level of detail retained by the hardware for each flow in such a way that the usable information is always retained, while the remaining data is processed by simpler methods. Flexibility of the concept is provided by a plugin-based design of both hardware and software, which ensures adaptability in the evolving world of network monitoring. Our high-speed implementation using FPGA acceleration board in a commodity server is able to perform a 100 Gb/s flow traffic measurement augmented by a selected application-level protocol analysis.
An Online Identification Based Energy Management Strategy for a Fuel Cell Hybrid Electric Vehicle (2019)

This paper aims to present an accurate Energy Management Strategy (EMS) for a Fuel Cell Hybrid Electric Vehicle (FC-HEV). Batteries and FC performances are constantly changing with aging, temperature and so on. In order to ensure the accuracy of the EMS the parameters of those models are constantly updated thanks to an online identification. Adaptive filtering, based on Recursive Least Square (RLS) algorithm, is used to estimate the State of Health (SOH) and the State of Charge (SOC) of the battery in one hand. On the other hand The RLS algorithm estimates the polarization curve of the Fuel Cell. The impact of those estimated parameters on the EMS is shown through simulation.
Intercritical circulating levels of neo-epitopes reflecting matrixmetalloprotease-driven degradation as markers of gout and frequent gout attacks (2016)

C1M and C3M, reflective of interstitial matrix destruction, are associated with gout status and with frequent gout flares in men, suggesting that increased MMP activity may contribute to gout flares. Further research is needed to find out whether this is independent of dietary and lifestyle risk factors for acute gout.
The Atacama Large Millimeter/submillimeter Array (2008)

The Atacama Large Millimeter/submillimeter Array (ALMA) is an international radio telescope under construction in the Atacama Desert of northern Chile. ALMA will be situated on a high-altitude site at 5000 m elevation, allowing excellent atmospheric transmission over the instrument wavelength range of 0.3 to 3 mm. ALMA will contain an array of up to sixty-four 12-m diameter high-precision antennas arranged in multiple configurations ranging in size from 150 meters up to ~15 km, and a set of four 12-m and twelve 7-m antennas operating in closely packed configurations ~50m in diameter. The instrument will provide both interferometric and total-power astronomical information on high-energy electrons, molecular gas and dust in solar system, our Galaxy, and the nearby and high-redshift universe. In this paper we outline the scientific drivers, technical challenges and construction status of ALMA.
Effects of Ligands on Unfolding of the Amyloid β-Peptide Central Helix: Mechanistic Insights from Molecular Dynamics Simulations (2012)

Polymerization of the amyloid β-peptide (Aβ), a process which requires that the helical structure of Aβ unfolds beforehand, is suspected to cause neurodegeneration in Alzheimer's disease. According to recent experimental studies, stabilization of the Aβ central helix counteracts Aβ polymerization into toxic assemblies. The effects of two ligands (Dec-DETA and Pep1b), which were designed to bind to and stabilize the Aβ central helix, on unfolding of the Aβ central helix were investigated by molecular dynamics simulations. It was quantitatively demonstrated that the stability of the Aβ central helix is increased by both ligands, and more effectively by Pep1b than by Dec-DETA. In addition, it was shown that Dec-DETA forms parallel conformations with β-strand-like Aβ, whereas Pep1b does not and instead tends to bend unwound Aβ. The molecular dynamics results correlate well with previous experiments for these ligands, which suggest that the simulation method should be useful in predicting the effectiveness of novel ligands in stabilizing the Aβ central helix. Detailed Aβ structural changes upon loss of helicity in the presence of the ligands are also revealed, which gives further insight into which ligand may lead to which path subsequent to unwinding of the Aβ central helix.
Cyclic minimizers, majorization techniques, and the expectation-maximization algorithm: a refresher (2004)

Many parameter estimation problems in signal processing can be reduced to the task of minimizing a function of the unknown parameters. This task is difficult owing to the existence of possibly local minima and the sharpness of the global minimum. In this article we review three approaches that can be used to minimize functions of the type encountered in parameter estimation problems. The first two approaches, the cyclic minimization and the majorization technique, are quite general, whereas the third one, the expectation-maximization (EM) algorithm, is tied to the use of the maximum likelihood (ML) method for parameter estimation. The article provides a quick refresher of the aforementioned approaches for a wide readership.
Facile Fabrication of Gold Nanoparticles-Poly(vinyl alcohol) Electrospun Water-Stable Nanofibrous Mats: Efficient Substrate Materials for Biosensors (2012)

Electrospun nanofibrous mats are intensively studied as efficient scaffold materials applied in the fields of tissue engineering, catalysis, and biosensors due to their flexibility and porosity. In this paper, we report a facile route to fabricate gold nanoparticles-poly(vinyl alcohol) (Au NPs-PVA) hybrid water stable nanofibrous mats with tunable densities of Au NPs and further demonstrate the potential application of as-prepared Au NPs-PVA nanofibrous mats as efficient biosensor substrate materials. First, through the designed in situ cross-linkage in coelectrospun PVA-glutaraldehyde nanofibers, water insoluble PVA nanofibrous mats with suitable tensile strength were successfully prepared. Then, 3-mercaptopropyltrimethoxysilane (MPTES) was modified on the surface of obtained PVA nanofibrous films, which triggered successful homogeneous decoration of Au NPs through gold-sulfur bonding interactions. Finally, the Au NPs-PVA nanofibrous mats embedded with horseradish peroxidase (HRP) by electrostatic interactions were used as biosensor substrate materials for H(2)O(2) detection. The fabricated HRP-Au NPs/PVA biosensor showed a highly sensitive detection of H(2)O(2) with a detection limit of 0.5 μM at a signal-to-noise ratio of 3. By modifying other different functional nanaoparticles or enzyme on the PVA nanofibrous film will further expand their potential applications as substrate materials of different biosensors.
Site-specific carbohydrate identification in recombinant proteins using MALD-TOF MS (1993)

The utility of matrix-assisted laser desorption time-of-flight (MALD-TOF) mass spectrometry for the analysis of recombinant glycopeptides is discussed and compared to information which may be obtained by fast atom bombardment mass spectrometry (FABMS) and tandem mass spectrometry (MS/MS). MALD-TOF appears to be 10-100 times more sensitive than FAB MS for the analysis of underivatized glycopeptides, providing qualitative site-specific information regarding the carbohydrate microheterogeneity without the extensive isolation and derivatization procedures required to obtain similar information by FAB MS. Analysis of a digest mixture in the positive and negative ion mode of MALD-TOF indicated that, in mixtures, sialylated glycopeptides are preferentially detected in the negative ion mode. The determination of the molecular masses of a glycopeptide with MALD-TOF prior to and after treatment with a variety of specific glycosidases, often without removal of the buffers, coupled to a comparison of molecular mass information available from a carbohydrate database facilitates the assignment of a carbohydrate composition. The vast majority of the molecular ion signal observed in the linear mode for sialylated glycopeptides are metastable ions. Reflector mass spectra reveal a shift to lower mass consistent with the loss of most of the neuraminic acid residues. The loss of Hex and HexNAc residues is also observed. Sequential lowering of the reflector potential reveals structurally significant fragment ions representing the carbohydrate and peptide portions of the molecule.
Risk Factors and Probability of Vertebral Body Collapse in Metastases of the Thoracic and Lumbar Spine (1997)

With respect to the timing and occurrence of vertebral collapse, there is a distinct discrepancy between the thoracic and thoracolumbar or lumbar spine. When a prophylactic treatment is required, the optimum timing and method of treatment should be selected according to the level and extent of the metastatic vertebral involvement.
Remote Laser Welding of Multi-Alloy Aluminum at Close-Edge Position (2013)

6000 series (magnesium and silicon based) aluminum alloys are highly susceptible to hot cracking during laser beam welding. The occurrence of hot cracks depends on thermo-mechanical strain at the solidifying stage of the melt and in the micro-scale on the solidification structure. A new metallurgical approach to avoid these cracks by affecting the solidification process is using a multi-alloy aluminum with a silicon-rich layer. Within this paper infrared videos were used to investigate and compare the behavior of this new material with the 6xxx monolithic alloy at hot crack sensitive close-edge positions.
A multi-scale model for simulating liquid-hair interactions (2017)

The diverse interactions between hair and liquid are complex and span multiple length scales, yet are central to the appearance of humans and animals in many situations. We therefore propose a novel multi-component simulation framework that treats many of the key physical mechanisms governing the dynamics of wet hair. The foundations of our approach are a discrete rod model for hair and a particle-in-cell model for fluids. To treat the thin layer of liquid that clings to the hair, we augment each hair strand with a height field representation. Our contribution is to develop the necessary physical and numerical models to evolve this new system and the interactions among its components. We develop a new reduced-dimensional liquid model to solve the motion of the liquid along the length of each hair, while accounting for its moving reference frame and influence on the hair dynamics. We derive a faithful model for surface tension-induced cohesion effects between adjacent hairs, based on the geometry of the liquid bridges that connect them. We adopt an empirically-validated drag model to treat the effects of coarse-scale interactions between hair and surrounding fluid, and propose new volume-conserving dripping and absorption strategies to transfer liquid between the reduced and particle-in-cell liquid representations. The synthesis of these techniques yields an effective wet hair simulator, which we use to animate hair flipping, an animal shaking itself dry, a spinning car wash roller brush dunked in liquid, and intricate hair coalescence effects, among several additional scenarios.
Lipid membrane analogs. Specific retention behavior in comb-shaped telomer-immobilized porous silica gels (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLipid membrane analogs. Specific retention behavior in comb-shaped telomer-immobilized porous silica gelsChuichi Hirayama, Hirotaka Ihara, and Tatsuya MukaiCite this: Macromolecules 1992, 25, 23, 6375–6376Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ma00049a041https://doi.org/10.1021/ma00049a041research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A cross-sectional examination of marketing of electronic cigarettes on Twitter (2014)

Twitter appears to be an important marketing platform for e-cigarettes. Tweets related to e-cigarettes were overwhelmingly commercial, and a substantial proportion mentioned smoking cessation. E-cigarette marketing on Twitter may have public health implications. Continued surveillance of e-cigarette marketing on social media platforms is needed.
POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks (2020)

Interhomolog recombination (IHR) occurs spontaneously in somatic human cells at frequencies that are low but sufficient to ameliorate some genetic diseases caused by heterozygous mutations or autosomal dominant mutations. Here we demonstrate that DNA nicks or double-strand breaks (DSBs) targeted by CRISPR-Cas9 to both homologs can stimulate IHR and associated copy-neutral loss of heterozygosity (cnLOH) in human cells. The frequency of IHR is 10-fold lower at nicks than at DSBs, but cnLOH is evident in a greater fraction of recombinants. IHR at DSBs occurs predominantly via reciprocal end joining. At DSBs, depletion of POLQ caused a dramatic increase in IHR and in the fraction of recombinants exhibiting cnLOH, suggesting that POLQ promotes end joining <i>in cis</i>, which limits breaks available for recombination <i>in trans</i> These results define conditions that may produce cnLOH as a mutagenic signature in cancer and may, conversely, promote therapeutic correction of both compound heterozygous and dominant negative mutations associated with genetic disease.
A Simple Test Method to Monitor Emission Control Operating State Space (Emission Control Failure & Defeat Device Recognition) (2016)

<div class="section abstract"><div class="htmlview paragraph">Modern light-duty vehicles require well-controlled engine-out feed-gas and very high catalyst efficiencies to meet the US Environmental Protection Agency (EPA) Tier 2 &amp; 3 standards. When a vehicle with either a gasoline or diesel engine is operating within its controlled state-space the exhaust emissions present at the tailpipe are extremely low. When it is not operating within its controlled state-space the combustion process and therefore its exhaust emissions characteristics will be different. This may occur when an emission control device fails or if a defeat device is employed. Moreover, different control technologies each have unique characteristics or signatures that could assist in identifying either emission control device failure or an existing defeat device.</div><div class="htmlview paragraph">A simple exhaust extension apparatus equipped with a thermocouple for measuring exhaust temperature and a NO<sub>x</sub> / O<sub>2</sub> sensor to measure tailpipe NO<sub>x</sub> and O<sub>2</sub> concentrations can characterize this signature information for pattern recognition analysis. This device can be used both in a laboratory environment with conventional batch sampling systems or for on-road testing as a compact emission measurement system.</div><div class="htmlview paragraph">If this information was acquired during conventional laboratory emissions tests it would provide valuable dynamic system information. This information could characterize events such as cold start open loop operation, engine transient fuel compensation, and high-speed load enrichment and emission control device status with minimal cost.</div></div>
Electrospun Nanofibers: Current Progress and Applications in Food Systems (2022)

Electrospinning has the advantages of simple manufacturing equipment, a low spinning cost, wide range of spinnable materials, and a controllable mild process, which can continuously fabricate submicron or nanoscale ultrafine polymer fibers without high temperature or high pressure. The obtained nanofibrous films may have a large specific surface area, unique pore structure, and easy-to-modify surface characteristics. This review briefly introduces the types and fiber structures of electrospinning and summarizes the applications of electrospinning for food production (e.g., delivery systems for functional food, filtration of beverages), food packaging (e.g., intelligent packaging, antibacterial packaging, antioxidant packaging), and food analysis (e.g., pathogen detection, antibiotic detection, pesticide residue detection, food compositions analysis), focusing on the advantages of electrospinning applications in food systems. Furthermore, the limitations and future research directions of the technique are discussed.
On heterogeneity in mobile sensing applications aiming at representative data collection (2013)

Gathering representative data using mobile sensing to answer research questions is becoming increasingly popular, driven by growing ubiquity and sensing capabilities of mobile devices. However, there are pitfalls along this path, which introduce heterogeneity in the gathered data, and which are rooted in the diversity of the involved device platforms, hardware, software versions and participants. Thus, we, as a research community, need to establish good practices and methodologies for addressing this issue in order to help ensure that, e.g., scientific results and policy changes based on collective, mobile sensed data are valid. In this paper, we aim to inform researchers and developers about mobile sensing data heterogeneity and ways to combat it. We do so via distilling a vocabulary of underlying causes, and via describing their effects on mobile sensing---building on experiences from three projects within citizen science, crowd awareness and trajectory tracking.
Identification and Mapping of Tomato Genome Loci Controlling Tolerance and Resistance to Tomato Brown Rugose Fruit Virus (2021)

Tomato brown rugose fruit virus (ToBRFV) was identified in Israel during October 2014 in tomato plants (<i>Solanum lycopersicum</i>). These plants, carrying the durable resistance gene against tomato mosaic virus, <i>Tm-2<sup>2</sup> </i>, displayed severe disease symptoms and losses to fruit yield and quality. These plants were found infected with a tobamovirus similar to that discovered earlier in Jordan. This study was designed to screen and identify tomato genotypes resistant or tolerant to ToBRFV. The identified resistance and tolerance traits were further characterized virologically and genetically. Finally, DNA markers linked to genes controlling these traits were developed as tools to expedite resistance breeding. To achieve these objectives, 160 genotypes were screened, resulting in the identification of an unexpectedly high number of tolerant genotypes and a single genotype resistant to the virus. A selected tolerant genotype and the resistant genotype were further analyzed. Analysis of genetic inheritance revealed that a single recessive gene controls tolerance whereas at least two genes control resistance. Allelic test between the tolerant and the resistant genotype revealed that these two genotypes share a locus controlling tolerance, mapped to chromosome 11. This locus displayed a strong association with the tolerance trait, explaining nearly 91% of its variation in segregating populations. This same locus displayed a statistically significant association with symptom levels in segregating populations based on the resistant genotype. However, in these populations, the locus was able to explain only ~41% of the variation in symptom levels, confirming that additional loci are involved in the genetic control of the resistance trait in this genotype. A locus on chromosome 2, at the region of the <i>Tm-1</i> gene, was finally found to interact with the locus discovered on chromosome 11 to control resistance.
Bottleneck Station Scheduling in Semiconductor Assembly and Test Manufacturing Using Ant Colony Optimization (2007)

In semiconductor assembly and test manufacturing (ATM), a station normally consists of multiple machines (maybe of different types) for a certain operation step. It is critical to optimize the utilization of ATM stations for productivity improvement. In this paper, we first formulate the bottleneck station scheduling problem, and then apply ant colony optimization (ACO) to solve it metaheuristically. The ACO is a biological-inspired optimization mechanism. It incorporates each ant agent's feedback information to collaboratively search for the good solutions. We develop the ACO-based scheduling framework and provide the system parameter tuning strategy. The system implementation at an Intel chipset factory demonstrates a significant machine conversion reduction comparing to a traditional scheduling approach.