gebhart/patrepeval huggingface dataset:
Audio-Material Reconstruction for Virtualized Reality Using a Probabilistic Damping Model (2019)

Modal sound synthesis has been used to create realistic sounds from rigid-body objects, but requires accurate real-world material parameters. These material parameters can be estimated from recorded sounds of an impacted object, but external factors can interfere with accurate parameter estimation. We present a novel technique for estimating the damping parameters of materials from recorded impact sounds that probabilistically models these external factors. We represent the combined effects of material damping, support damping, and sampling inaccuracies with a probabilistic generative model, then use maximum likelihood estimation to fit a damping model to recorded data. This technique greatly reduces the human effort needed and does not require the precise object geometry or the exact hit location. We validate the effectiveness of this technique with a comprehensive analysis of a synthetic dataset and a perceptual study on object identification. We also present a study establishing human performance on the same parameter estimation task for comparison.
A Critique of the CAP Theorem (2015)

The CAP Theorem is a frequently cited impossibility result in distributed systems, especially among NoSQL distributed databases. In this paper we survey some of the confusion about the meaning of CAP, including inconsistencies and ambiguities in its definitions, and we highlight some problems in its formalization. CAP is often interpreted as proof that eventually consistent databases have better availability properties than strongly consistent databases; although there is some truth in this, we show that more careful reasoning is required. These problems cast doubt on the utility of CAP as a tool for reasoning about trade-offs in practical systems. As alternative to CAP, we propose a "delay-sensitivity" framework, which analyzes the sensitivity of operation latency to network delay, and which may help practitioners reason about the trade-offs between consistency guarantees and tolerance of network faults.
Dual arm robot manipulator and its easy teaching system (2009)

The dual arm robot manipulator has been developed and it easy teaching system has been developed also. The manipulator consists of two industrial 6-DOF arms and one 2-DOF torso and it was designed for the assembly automation of the automotive parts. Two-arm robot system has more advantageous than the traditional single arm robot system. But it is more difficult to teach the dual arm robot system. In this paper, the research results on the dual arm robot manipulator and its easy teaching system will be introduced.
Development and Performance Studies of a Small Animal Positron Emission Tomograph with Individual Crystal Readout and Depth of Interaction Information and Studies of Novel Detector Technologies in Medical Imaging (2008)

The Munich Avalanche Diode PET-II is a positron emission tomograph for radiopharmaceutical studies in small animals. The detector architecture is based on individual readout of Lutetium Oxyorthosilicate (LSO) scintillation crystals by Avalanche Photodiodes (APD). A dual radial detector layer allows for extraction of depth of interaction information. Energy and time resolution have been investigated under various conditions with regard to readout electronics and temperature. A first animal study has been conducted. The feasibility of using silicon photomultipliers (SiPMs) as light sensors in MR compatible PET detectors has been studied. Using single channel devices, it could be shown that LSO-SiPM detectors exhibit a comparable energy resolution and a superior time resolution compared to LSO-APD detectors even by eliminating the need for complicated amplification electronics. Operation under the presence of magnetic fields has not shown degradation of the mentioned performance.
High-Throughput Sequencing of the Methylome Using Two-Base Encoding (2012)

Methylation of Cytosine together with other epigenetic traits plays an important role in the development and regulation of both healthy and diseased cells. Changes in the methylation patterns have been shown to be associated with the development of cancer, growth, neurodevelopmental, and endocrine disorders (Laird PW, Nat Rev Genet 11:191-203, 2010; Tost J, Mol Biotechnol 44:71-81, 2010; Zuo T et al., Epigenomics 1:331-345, 2009). Thus, studying the methylation pattern can give important insights to the underlying causes of disease and development. A method for studying the methylome on a single base resolution is described, using bisulfite sequencing in combination with the high-throughput SOLiD(TM) sequencing technology.
Comparison of the EEG Effects of Midazolam, Thiopental, and Propofol: The Role of Underlying Oscillatory Systems (1997)

The EEG effects of 3 intravenous sedative drugs from different chemical families were studied during conscious sedation in 47 normal volunteers. The drugs studied were midazolam (a benzodiazepine), propofol (an alkylphenol) and thiopental (a barbiturate). Though these drugs cause different degrees of amnesia, they have the common EEG effects of suppressing alpha-rhythm and increasing total beta-power. A large portion of the increase in beta-power can be accounted for by beta-rhythms. We used the UNIFAC-EEG technique to differentiate oscillatory systems underlying the rhythms induced by these drugs in a quantitative fashion. While thiopental induced beta-rhythms which were similar to those appearing during drowsiness, midazolam and propofol induced beta-rhythms with substantially different characteristics. The differences between the beta-rhythms induced by drug infusion and previously described 'sleep spindles' are discussed. We conclude that a quantitative analysis of beta-rhythms can differentiate the effects of these drugs on the EEG.
Sequential monte carlo samplers (2002)

This paper shows how one can use Sequential Monte Carlo methods to perform what is typically done using Markov chain Monte Carlo methods. This leads to a general class of principled integration and genetic type optimization methods based on interacting particle systems.
Endo‐sponge treatment of anastomotic leakage after ileo‐anal pouch anastomosis: report of two cases (2008)

Vacuum endo-sponge treatment can help anastomotic leakage after ileo-anal pouch surgery.
A phase I study of MEK inhibitor MEK162 (ARRY-438162) in patients with biliary tract cancer. (2012)

220 Background: The RAS/RAF/MEK/ERK pathway plays a major role in cell growth and survival and is aberrantly activated in many cancers. MEK162 (ARRY-438162) is a potent, selective, ATP-uncompetitive inhibitor of MEK1/2. The objectives of this Phase 1 expansion study were to characterize the safety, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary efficacy of MEK162 in patients (pts) with biliary tract cancer (BTC). Methods: Pts with unresectable, locally advanced or metastatic BTC who had received ≤ 1 prior systemic therapy received oral MEK162 at 60 mg twice daily (BID). Mutation status of RAS, BRAF and other relevant genes were assessed from tumor samples. Tumor response was assessed every 6 weeks. Results: Twenty-eight pts, median age 64 years (range 30-86) with gallbladder (7), intrahepatic (14) or extrahepatic (7) cholangiocarcinoma (CC) were enrolled. All pts were ECOG 0-1 and 43% received previous first-line therapy (primarily gemcitabine combinations). Of the 23 tumors assessed, 17 were wild type (WT) on all loci tested and 6 had mutations (1 MET, 1 PIK3CA, 2 KRAS, 2 PTEN null). The most common treatment-related AEs were rash, nausea, vomiting, diarrhea, peripheral edema, fatigue and central serous-like retinopathy, and most were Grade (G) 1 or 2. G3/4 treatment-related AEs were anasarca, hypokalemia, hyponatremia, upper/lower gastrointestinal hemorrhage and mucositis (1 each). Thirteen pts were dose reduced for AEs, of which, G1/2 central serous-like retinopathy was the most frequently reported event (6). Three pts were discontinued for treatment-related AEs (G2 central serous-like retinopathy, G1 nausea, G4 anasarca). Of the 26 pts evaluable for response, 1 CR, 1 PR and 11 SD (≥ 6 weeks) were observed. Of note, both responders were WT on all loci tested and had extrahepatic CC. The PK in this population was equivalent to that observed in prior studies. A consistent mean reduction (40-60%) of circulating TNFα was observed. Conclusions: MEK162 has an acceptable safety profile and desirable PK properties at 60 mg BID and RECIST responses were observed in pts with BTC. Additional expansion cohorts are ongoing in pts with KRAS- or BRAF-mutant metastatic colorectal cancer.
Photochemical coupling of 5-bromouracil (BU) to a peptide linkage. A model for BU-DNA protein photocrosslinking (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical coupling of 5-bromouracil (BU) to a peptide linkage. A model for BU-DNA protein photocrosslinkingTimothy M. Dietz, Robert J. Von Trebra, Barry J. Swanson, and Tad H. KochCite this: J. Am. Chem. Soc. 1987, 109, 6, 1793–1797Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/ja00240a032https://doi.org/10.1021/ja00240a032research-articleACS PublicationsRequest reuse permissionsArticle Views314Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Testing 24 volt aircraft batteries using Midtronics conductance technology (2002)

Midtronics in cooperation with both US and UK battery users have performed both conductance and discharge capacity tests on literally thousands of batteries and cells in two, six and twelve volt configurations. The results of these extensive studies have been published in several technical papers presented to various technical and industry groups in North America, Europe and Asia. These papers clearly demonstrate the utility of conductance technology for determining battery state-of-health and show analytical procedures for identification of premature capacity failures. This paper shows the results from VRLA (valve regulated lead-acid) 24 volt synthesized equivalent monobloc batteries using an averaging procedure for single cell conductance capacity data measured from 1000 ampere-hour telecommunications batteries. These synthesized data are used to demonstrate the correlation, diagnostic sensitivity and utility of the conductance measurements as applied to the 24 volt battery configuration generally used in aircraft applications. This paper also presents test data on a limited number of 24 volt aircraft battery systems, which indicate that conductance measurements are capable of detecting batteries with seriously deteriorated capacity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reverse Biomembrane Vesicles for Effective Controlled Delivery of Doxorubicin HCl (2000)

A new derivative of erythrocyte ghosts--reverse biomembrane vesicles (RBVs)--was developed, loaded with doxorubicin HCl (Dox RBVs), and extensively characterized both in vivo and in vitro. The formulation of reverse biomembrane is based on budding of membrane into the ghost interiors (endocytosis) leading to accumulation of small vesicles within each parent ghost. The system was evaluated in vitro for entrapment efficiency, membrane orientation, vesicle size, release profile, and centrifugal stress. The stability studies were performed at 4 degrees C by assessing the effect on vesicle size and leakage after 7, 15, and 21 days. The stability study showed negligible leakage and no appreciable change in vesicle size after storage for several days--an indication of good stability of RBVs formulation. The formulation and process variables were optimized to obtain vesicles of 1.2-1.8 microm. The amount of doxorubicin entrapped in RBVs was 0.75 mg/ml of packed vesicles. The in vitro release profile showed 52.86% of drug release in 16 hr. A membrane orientation study revealed inversion of membrane surface because only 10% of sialic acid was accessible on trypsin treatment. The plasma clearance data revealed an increase in half-life and bioavailability of drug. Tissue concentration data suggest that liver and spleen remain the major organs for clearance of these drug-loaded RBVs, which suggests preferential uptake by the reticuloendothelial system. On the whole, this vesicle system proved to be of potential application in cancer chemotherapy.
Droplet Evaporation of Pure Water and Protein Solution on Nanostructured Superhydrophobic Surfaces of Varying Heights (2009)

Evaporation of liquids on substrates is important for many applications including lab-on-a-chip, especially when they are in droplets. Unlike on planar substrates, droplet evaporation on micropatterned substrates has been studied only recently and none so far on nanopatterns. Driven by the applicability of nanostructured surfaces to biomaterials and tissue engineering, we report on the evaporative process of sessile droplets of pure water and a protein solution on superhydrophobic surfaces of sharp-tip post structures in a submicrometer pitch (230 nm) and varying heights (100−500 nm). We find that the nanotopographical three-dimensionalities such as structural height and sidewall profile affect the surface superhydrophobicity in such a way that only tall and slender nanostructures provide the surface with great superhydrophobicity (a contact angle more than 170°). The evaporation process was different between the pure water and the protein solution; unlike pure water, a significant contact-line spreading and pinning effect was observed in a droplet of a protein solution with an intermediate transition from a dewetting (Cassie) to a wetting (Wenzel) state. Enabled by well-defined nanostructures, our results highlight that the surface superhydrophobicity and the droplet evaporation are significantly affected by the three-dimensional nanometric topography and the surface fouling such as protein adsorption.
A semi-automatic source code documentation method for small software development teams (2011)

Software developers often face the task of documenting source code. For many of them, documenting code development is a boring task. However, source code documentation is an important task, especially when dealing with groups of developers. An updated documentation allows group members to have greater visibility on what has been and is being developed, allowing the reuse of source code. This research aims at designing, developing and validating a semi-automatic documentation method for source code from the existing design documentation on a particular project being developed by a small team, as well as updating this documentation from information gathered from the source code under development. It is understood as design documentation, those documents or parts of documents that are linked directly to the code under construction.
Laser-assisted nanofabrication of carbon nanostructures (2012)

An overview of laser-assisted techniques developed in our group for fabricating carbon nanostructures, including two-dimensional graphene, one-dimensional carbon nanotubes, and zero-dimensional carbon nanoonions, is presented. Unique laser-material interactions provide versatile possibilities in fabricating carbon nanostructures, including localized heating, direct laser writing, tip-enhanced optical near-field effect, polarization, ablation, resonant excitation, precise energy delivery, and mask-free direct patterning. Rapid single-step fabrication of graphene patterns was achieved using laser directing writing. Parallel integration of single-walled carbon nanotubes was realized by making use of tip-enhanced optical near-field effect. High-quality carbon nanoonions were obtained through laser resonant excitation of precursor molecules.
Confined collective excitations of self-standing and supported planar periodic particle arrays (2009)

We find the conditions for the existence of trapped modes in planar periodic particle arrays. Confined excitations of TE and TM symmetry are observed in symmetric environments, originating in lattice resonances that are signalled by the onset of new diffraction beams. This mechanism of mode formation is shown to be inhibited by the presence of a dielectric interface in an asymmetric configuration. Modes can still exist above a threshold finite distance from the interface. Both rigorous numerical simulation and analytical modeling are used to elucidate the origin and systematics of this unexpected difference in the behavior of trapped modes in self-standing and supported particle arrays.
Interactive Gradebook: The Missing (Hyper)Link (1998)

Cultivated peanut (Arachis hypogaea L.) is a major oilseed crop providing edible oil and protein. Oil quality is determined by fatty acid composition including the ratio of oleic acid (C18:1) and linoleic acid (C18:2). A genome-wide association study with 13,382 single nucleotide polymorphisms (SNPs) was conducted to investigate the genetics basis of oil, protein, eight fatty acid concentrations, and O/L ratio (ratio of oleic and linoleic acid) using a diverse panel of 120 genotypes mainly selected from the U.S. peanut mini core collection grown in two years. A total of 178 significant quantitative trait loci (QTLs) associated with those seed composition traits were identified with phenotypic variation explained (PVE) from 18.35% to 27.56%. RNA-Seq analysis identified 282 DEGs (differentially expressed genes) within the 1 Mb of the significant QTLs for seed composition traits. Among those 282 genes, sixteen candidate genes for seed fatty acid metabolism and protein synthesis were screened according to the gene functions.
Multiple actions of <i>Lucilia sericata</i> larvae in hard‐to‐heal wounds (2013)

In Europe ≈15,000 patients receive larval therapy for wound treatment annually. Over the past few years, clinical studies have demonstrated the success of larvae of Lucilia sericata as debridement agents. This is based on a combination of physical and biochemical actions. Laboratory investigations have advanced our understanding of the biochemical mechanisms underlying the beneficial effects of larval secretions, including removal of dead tissue, reduction of the bacterial burden, and promotion of tissue regeneration. The present article summarizes our current understanding of the microbiological, immunological, and wound healing actions of larval therapy, and the molecules involved in these beneficial effects. Future studies will focus on the isolation, identification, and (pre)clinical testing of the effective molecules of L. sericata larvae. These molecules may be candidates for the development of new agents for the treatment of several infectious and inflammatory diseases, including chronic wounds.
Clinical applications of mesenchymal stem cells (2013)

Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation and exert potent immunosuppressive and anti-inflammatory effects through interactions between lymphocytes associated with both the innate and adaptive immune system. Along with these unique therapeutic properties, their ease of accessibility and expansion suggest that use of MSCs may be a useful therapeutic approach for various disorders. In the clinical setting, MSCs are being explored in trials of various conditions, including orthopedic injuries, graft versus host disease following bone marrow transplantation, cardiovascular diseases, autoimmune diseases, and liver diseases. Furthermore, genetic modification of MSCs to overexpress antitumor genes has provided prospects for clinical use as anticancer therapy. Here, we highlight the currently reported uses of MSCs in clinical trials and discuss their efficacy as well as their limitations.
A novel low-cost small-form-factor transceiver module (2002)

A key trend in the optoelectronic data-communication industry is the move towards lower cost and smaller transceivers. This trend has driven transceiver modules to the Small-Form-Factor (SFF) dimensions, requiring SFF optical connectors, resulting in a cost lower than their larger predecessors (for example GBICs or 1/spl times/9 transceivers based on the larger duplex SC optical connector). The design and implementation of a low-cost SFF fiber optic transceiver based on the SFF LC fiber optic connector is discussed. Since most of the transceiver cost is associated with the optical subassemblies (OSAs), low cost, yet smaller OSAs are required. In addition, the entire transceiver assembly has been optimized for cost reduction by using direct-chip-attach electronics, and surface-mount components all mounted on a single card that snaps into a plastic-molded retainer. These SFF LC transceivers are well suited for Gigabit Ethernet, Fibre Channel, and 1394b applications, along with other applications requiring low cost data transfer at data rates of 1.25 Gb/s to 2.125 Gb/s, or higher.
The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G<sub>2</sub> Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents (2003)

Although human cells exposed to DNA-methylating agents undergo mismatch repair (MMR)-dependent G(2) arrest, the basis for the linkage between MMR and the G(2) checkpoint is unclear. We noted that mitogen-activated protein kinase p38alpha was activated in MMR-proficient human glioma cells exposed to the chemotherapeutic methylating agent temozolomide (TMZ) but not in paired cells made MMR deficient by expression of a short inhibitory RNA (siRNA) targeted to the MMR protein Mlh1. Furthermore, activation of p38alpha in MMR-proficient cells was associated with nuclear inactivation of the cell cycle regulator Cdc25C phosphatase and its downstream target Cdc2 and with activation of the G(2) checkpoint, actions which were suppressed by the p38alpha/beta inhibitors SB203580 and SB202590 or by expression of a p38alpha siRNA. Finally, pharmacologic or genetic inhibition of p38alpha increased the sensitivity of MMR-proficient cells to the cytotoxic actions of TMZ by increasing the percentage of cells that underwent mitotic catastrophe as a consequence of G(2) checkpoint bypass. These results suggest that p38alpha links DNA MMR to the G(2) checkpoint and to resistance to chemotherapeutic DNA-methylating agents. The p38 pathway may therefore represent a new target for the development of agents to sensitize tumor cells to chemotherapeutic methylating agents.