gebhart/patrepeval huggingface dataset:
Fabrication and characterization of glassy carbon linear array electrodes (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFabrication and characterization of glassy carbon linear array electrodesL. Joseph. Magee and Janet. OsteryoungCite this: Anal. Chem. 1989, 61, 18, 2124–2126Publication Date (Print):September 15, 1989Publication History Published online1 May 2002Published inissue 15 September 1989https://pubs.acs.org/doi/10.1021/ac00193a026https://doi.org/10.1021/ac00193a026research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes (2013)

Significant differences exist between ETR and PPR in rosacea-associated features and in subtype associations. A small proportion of subjects with rosacea may progress between subtypes.
Energy Spectrum Measurement of High Power and High Energy (6 and 9 MeV) Pulsed X-ray Source for Industrial Use (2016)

Background: Industrial X-ray CT system is normally applied to non-destructive testing (NDT) for industrial product made from metal. Furthermore there are some special CT systems, which have an ability to inspect nuclear fuel assemblies or rocket motors, using high power and high energy (more than 6 MeV) pulsed X-ray source. In these case, pulsed X-ray are produced by the electron linear accelerator, and a huge number of photons with a wide energy spectrum are produced within a very short period. Consequently, it is difficult to measure the X-ray energy spectrum for such accelerator-based X-ray sources using simple spectrometry. Due to this difficulty, unexpected images and artifacts which lead to incorrect density information and dimensions of specimens cannot be avoided in CT images. For getting highly precise CT images, it is important to know the precise energy spectrum of emitted X-rays.
High energy fiber chirped pulse amplification system based on cubicons (2005)

The generation of stretched 20 pJ pulses with 200 kW peak power is demonstrated in an in-line Yb fiber chirped pulse amplification system at a repetition rate of 50 kHz. The pulses are compressible down to 400 fs using nonlinear cubical dispersion compensation.
Bone Morphogenetic Protein Binding Peptide Mechanism and Enhancement of Osteogenic Protein-1 Induced Bone Healing (2010)

The mechanism of the BBP enhanced osteoinductive properties of BMPs involves the binding and retention of the growth factor, resulting in a prolonged exposure of BMP to the desired fusion site. The use of BBP in conjunction with BMPs may prove to provide satisfactory fusion outcomes, while reducing the costs and side effects associated with BMP use.
Species-specific oligonucleotide probes for five Bifidobacterium species detected in human intestinal microflora (1992)

Portions of the 16S rRNA from closely related species of the genus Bifidobacterium that are found in the human intestinal microflora were sequenced in order to design species-specific oligonucleotide probes. Five oligonucleotide probes ranging from 16 to 19 bases in length and complementary to 16S rRNA sequences from Bifidobacterium adolescentis, B. bifidum, B. breve, B. infantis, and B. longum were synthesized. With crude high-molecular-weight RNA preparations as targets, these probes showed the desired species specificity, even down to a 1-nucleotide difference. For the practical evaluation of these probes, their specificity and sensitivity were tested against seven strains of the same species and 54 strains of heterologous bacteria with fixed whole cells as targets. The probes for B. adolescentis, B. breve, and B. longum showed efficient and specific hybridization. Although the probes for B. bifidum and B. infantis cross-reacted with a few bacterial strains not isolated from humans, these probes showed species specificity for human intestinal bacteria. These 16S rRNA probes should prove valuable for the identification and detection of human intestinal Bifidobacterium species.
Leber's hereditary optic neuropathy: a model for mitochondrial neurodegenerative diseases (1992)

A number of human diseases have been attributed to defects in oxidative phosphorylation (OXPHOS) resulting from mutations in the mitochondrial DNA (mtDNA). One such disease is Leber's hereditary optic neuropathy (LHON), a neurodegenerative disease of young adults that results in blindness due to atrophy of the optic nerve. The etiology of LHON is genetically heterogeneous and in some cases multifactorial. Eleven mtDNA mutations have been associated with LHON, all of which are missense mutations in the subunit genes for the subunits of the electron transport chain complexes I, III, and IV. Molecular, biochemical, and population genetic studies have categorized these mutations as high risk (class I), low risk (class II), or intermediate risk (class I/II). Class I mutations appear to be primary genetic causes of LHON, while class II mutations are frequently found associated with class I genotypes and may serve as exacerbating genetic factors. Different LHON pedigrees can harbor different combinations of class I, II, or I/II mtDNA mutations, as shown by the complete sequence analysis of the mtDNAs of four LHON probands. The various mtDNA genotypes included an isolated class I mutation, combined class I+II mutations, and combined class I/II+II mutations. The occurrence of such genotypes supports the hypothesis that LHON may result from the additive effects of various genetic and environmental insults to OXPHOS, each of which increases the probability of blindness.
A differential binary message-passing LDPC decoder (2009)

In this paper, we propose a binary message-passing algorithm for decoding low-density parity-check (LDPC) codes. The algorithm substantially improves the performance of purely hard-decision iterative algorithms with a small increase in the memory requirements and the computational complexity. We associate a reliability value to each nonzero element of the code's parity-check matrix, and differentially modify this value in each iteration based on the sum of the extrinsic binary messages from the check nodes. For the tested random and finitegeometry LDPC codes, the proposed algorithm can perform as close as about 1 dB and 0.5 dB to belief propagation (BP) at the error rates of interest, respectively. This is while, unlike BP, the algorithm does not require the estimation of channel signal to noise ratio. Low memory and computational requirements and binary message-passing make the proposed algorithm attractive for high-speed low-power applications.
Formation of Metallurgical Coke within Minutes through Coal Densification and Microwave Energy (2019)

This paper shows how feedstock densification gives rise to a step change in the time required to create a metallurgical grade coke using microwave energy. Five densified coking and noncoking coals were heated in a multimode microwave 2450 MHz cavity for varying treatment times (2–20 min) with a fixed power input (6 kW). Proximate analysis, intrinsic reactivity, coke reactivity, dielectric properties, and petrographic analysis of the coals and microwave-produced lump cokes were compared to a commercial lump coke. Densifying the sample prior to microwave treatment enabled a dramatic acceleration of the coking process when combined with targeted high microwave energy densities. It was possible to form fused coke lump structures with only 2 min of microwave heating compared to 16–24 h via conventional coking. Anisotropic coke morphologies (lenticular and circular) were formed from noncoking coal that are not possible with conventional coking, and increasing the treatment time improved overall coke reflectance. Three of the coals produced coke with equivalent coke reactivity index values of 20–30, which are in the acceptable range for blast furnaces. The study demonstrated that via this process, noncoking coals could potentially be used to produce high quality cokes, potentially expanding the raw material options for metallurgical coke production.
Design and experiment research of integrated EMI filter based on flexible multi-layer foils (2010)

A novel passive integration structure based on flexible multi-layer foils was proposed for EMI filter in switching-mode power supply. Common mode (CM) inductors and capacitors, differential mode (DM) inductors and capacitors were all integrated in a single unit. This passive integration applied flexible multi-layer foils (FML). Prototypes were implemented for an 1 kW switching power supply. The conductive EMI testing result was presented. The temperature rising and efficiency curves of the integrated EMI filter were also presented. In comparison with the discrete EMI filter, the prototype in this paper can reduce the volume by 32%.
Abstract 15845: Intracoronary Delivery of Exosomes Secreted by Cardiosphere-Derived Cells Confers Cardioprotection wWth Delayed Administration After Ischemia-Reperfusion Injury in Rats (2014)

Introduction: Cardiosphere-Derived Cells (CDCs) exert both regenerative and cardioprotective effects following ischemic insult to the myocardium despite limited cell engraftment. Here we demonstrate that exosomes (30-150nm lipid bilayer vesicles) secreted from human CDCs (hCDCs) confer a dose-dependent reduction in infarct size and preservation of cardiac function when infused into the coronary circulation in rats following ischemia/reperfusion (IR) injury.

Methods & Results: To examine the safety and efficacy of CDC-exosomes (EXOCDC), we performed a dose-finding study in Wistar-Kyoto rats (WKY; aged 8-12 weeks). Briefly, conditioned media was collected from hCDCs grown in serum-free media for 4 days then EXOCDCs were precipitated using ExoQuick-TC (SBI). As a starting dose, EXOCDCs were isolated from an equivalent, and previously-validated, CDC dose for intracoronary delivery following IR (3mL/3x105 CDCs). EXOCDC protein quantity was determined (~700ug/10mL) and doses were titrated. For in vivo analyses, WKY rats underwent 45 minutes of ischemia followed by 20 minutes of reperfusion. Animals were then randomly allocated to receive either PBS or a titrated dose of EXOCDC (derived from 10mL, 3mL, or 1mL CDC-conditioned media). Two days following injury, all EXOCDC doses (10mL, 3mL, and 1mL) conferred a significant reduction in percent infarct mass relative to PBS control (PBS: 13.56% vs. 10mL: 6.38%; 3mL: 6.94%; 1mL: 8.03% p<0.05). Similarly, ejection fraction was preserved in the lower doses (PBS: 43.07% vs. 10mL: 57.40%; 3mL: 58.17%; 1mL: 55.49%; p<0.05). Interestingly, these EXOCDC express a unique surface protein signature comprising some generic markers from exosomes (CD63, HSP70, but not CD9 or CD81) as well as CDC-specific markers (CD105).

Conclusions: Cell-free EXOCDC, delivered via the intracoronary route 20 min post-IR, are cardioprotective. The evaluation of efficacy at 48 hours rules out regenerative effects, which become manifest over weeks. The ability to delay administration after IR renders the protocol clinically-realistic. Thus, EXOCDC may be useful cardioprotective therapeutic candidates adjunctive to routine therapy for myocardial infarction.
Laser differential fitting confocal microscopy with high imaging efficiency (2016)

Based on the optical arrangement of a bipolar differential confocal microscopy (BDCM), laser differential fitting confocal microscopy (DFCM) is proposed in this paper using the feature of BDCM that a zero-crossing point (ZCP) of the axial response curve precisely corresponds to the focus of the system objective. A linear segment of the DFCM axial response around the ZCP is used to fit a straight line. Focus can be determined by solving the equations of the fitting lines, and then, the sample surface could be measured and reconstructed with a high resolution. Compared with the curve-fitting peak detection, which is an algorithm for focus detection widely used in conventional confocal microscopy, the line-fitting zero solution method used in DFCM has several advantages, such as high precision and sensitivity. Most importantly, precise focus detection can be realized using less data, i.e., DFCM has a high measurement efficiency. Furthermore, DFCM can effectively eliminate common-mode noise in a confocal microscopy system and has good noise suppression and disturbance resistance capability.
CVD method for forming B.sub.i -containing oxide superconducting films (1994)

Films of high T.sub.c Bi-Sr-Ca-Cu-O superconductor have been prepared by MOCVD using volatile metal organic precursors and water vapor. The metal organic precursors are volatized along with a bismuth source, such as Bi(C.sub.6 H.sub.5).sub.3, deposited on a heated substrate to form a film, and annealed.
Synchronizing chaotic circuits (1991)

The authors describe the conditions necessary for synchronizing a subsystem of one chaotic system with a separate chaotic system by sending a signal from the chaotic system to the subsystem. The general scheme for creating synchronizing systems is to take a nonlinear system, duplicate some subsystem of this system, and drive the duplicate and the original subsystem with signals from the unduplicated part. This is a generalization of driving or forcing a system. The process can be visualized with ordinary differential equations. The authors have build a simple circuit based on chaotic circuits described by R. W. Newcomb et al. (1983, 1986), and they use this circuit to demonstrate this chaotic synchronization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A multigrid fluid pressure solver handling separating solid boundary conditions (2011)

We present a multigrid method for solving the linear complementarity problem (LCP) resulting from discretizing the Poisson equation subject to separating solid boundary conditions in an Eulerian liquid simulation's pressure projection step. The method requires only a few small changes to a multigrid solver for linear systems. Our generalized solver is fast enough to handle 3D liquid simulations with separating boundary conditions in practical domain sizes. Previous methods could only handle relatively small 2D domains in reasonable time because they used expensive quadratic programming (QP) solvers. We demonstrate our technique in several practical scenarios in which the omission of separating boundary conditions results in disturbing artifacts of liquid sticking to walls.
Characterization of fluids via measurement of the rotational dynamics of suspended magnetic microdiscs (2015)

This paper proposes, analyzes, and demonstrates a method to characterize fluids by monitoring the rotational dynamics of 2.5-μm-diameter magnetic microdiscs in suspension via optical interrogation. The free-floating discs function like synchronized micro-shutters when actuated by an external magnetic field. Their motion is monitored via light transmission in response to a rotating magnetic field. The disc rotation is found, both theoretically and experimentally, to depend on the amplitude and the rotation frequency of the applied magnetic field with a high sensitivity to fluid viscosity changes from 1 to 2 mPa s, independent of the disc concentration in the solution from 20 to 120 M/ml. Consequently, the discs can function as microsensors via simple optical measurements.
Identification of the Sulfated Monosaccharides of GlyCAM-1, an Endothelial-Derived Ligand for L-Selectin (1994)

L-Selectin, a receptor bearing a C-type lectin domain, mediates the initial attachment of lymphocytes to high endothelial venules of lymph nodes. One of the endothelial-derived ligands for L-selectin is GlyCAM-1 (previously known as Sgp50), a mucin-like glycoprotein with sulfated, sialylated, and fucosylated O-linked oligosaccharide chains. Sialylation, sulfation, and fucosylation appear to be required for the avid interaction of this ligand with L-selectin, but the exact carbohydrate structures involved in recognition remain undefined. In this study, we examine the nature of the sulfate-modified carbohydrates of GlyCAM-1. GlyCAM-1 was metabolically labeled in lymph node organ culture with 35SO4 and a panel of tritiated carbohydrate precursors. Mild hydrolysis conditions were established that released sulfated oligosaccharides without cleavage of sulfate esters. Low molecular weight and singly charged fragments, obtained by a combination of gel filtration and anion-exchange chromatography, were analyzed. The structural identification of the fragments relied on the use of a variety of radiolabeled sugar precursors, further chemical and enzymatic hydrolysis, and high-pH anion-exchange chromatography analysis. Sulfated constituents of GlyCAM-1 were identified as Gal-6-SO4, GlcNAc-6-SO4, (SO4-6)Gal beta 1-->4GlcNAc, and Gal beta 1-->4(SO4-6)GlcNAc. In the accompanying paper [Hemmerich, S., & Rosen, S.D. (1994) Biochemistry 33, 4830-4835] evidence is presented that (SO4-6)Gal beta 1-->4GlcNAc forms the core of a sulfated sialyl Lewis x structure that may comprise a recognition determinant on GlyCAM-1.
Analysis of mutually decoupled primary coils for IPT systems for EV charging (2016)

Inductive Power Transfer (IPT) systems have been proposed for various applications and have been increasingly gaining interest for electric vehicle (EV) charging. Numerous magnetic structures have been proposed for IPT systems for EV charging including structures involving mutually decoupled coils. This paper presents an analytical model of an IPT system composed of a two coil primary pad and a single coil secondary pad to show the importance of mutually decoupled coils in IPT systems using multi-coil primary pads. A controller is also proposed to find the optimal primary currents needed to achieve the “best” effective coupling factors at any secondary displacement for mutually decoupled primary coils. A 1.5 kW prototype system is implemented in the laboratory to validate the findings for ideally aligned and misaligned cases.
Synthetic surfactant containing SP-B and SP-C mimics is superior to single-peptide formulations in rabbits with chemical acute lung injury (2014)

Background. Chemical spills are on the rise and inhalation of toxic chemicals may induce chemical acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Although the pathophysiology of ALI/ARDS is well understood, the absence of specific antidotes has limited the effectiveness of therapeutic interventions. Objectives. Surfactant inactivation and formation of free radicals are important pathways in (chemical) ALI. We tested the potential of lipid mixtures with advanced surfactant protein B and C (SP-B and C) mimics to improve oxygenation and lung compliance in rabbits with lavage- and chemical-induced ALI/ARDS. Methods. Ventilated young adult rabbits underwent repeated saline lung lavages or underwent intratracheal instillation of hydrochloric acid to induce ALI/ARDS. After establishment of respiratory failure rabbits were treated with a single intratracheal dose of 100 mg/kg of synthetic surfactant composed of 3% Super Mini-B (S-MB), a SP-B mimic, and/or SP-C33 UCLA, a SP-C mimic, in a lipid mixture (DPPC:POPC:POPG 5:3:2 by weight), the clinical surfactant Infasurf(®), a bovine lung lavage extract with SP-B and C, or synthetic lipids alone. End-points consisted of arterial oxygenation, dynamic lung compliance, and protein and lipid content in bronchoalveolar lavage fluid. Potential mechanism of surfactant action for S-MB and SP-C33 UCLA were investigated with captive bubble surfactometry (CBS) assays. Results. All three surfactant peptide/lipid mixtures and Infasurf equally lowered the minimum surface tension on CBS, and also improved oxygenation and lung compliance. In both animal models, the two-peptide synthetic surfactant with S-MB and SP-C33 UCLA led to better arterial oxygenation and lung compliance than single peptide synthetic surfactants and Infasurf. Synthetic surfactants and Infasurf improved lung function further in lavage- than in chemical-induced respiratory failure, with the difference probably due to greater capillary-alveolar protein leakage and surfactant dysfunction after HCl instillation than following lung lavage. At the end of the duration of the experiments, synthetic surfactants provided more clinical stability in ALI/ARDS than Infasurf, and the protein content of bronchoalveolar lavage fluid was lowest for the two-peptide synthetic surfactant with S-MB and SP-C33 UCLA. Conclusion. Advanced synthetic surfactant with robust SP-B and SP-C mimics is better equipped to tackle surfactant inactivation in chemical ALI than synthetic surfactant with only a single surfactant peptide or animal-derived surfactant.
2.5D cartoon models (2010)

We present a way to bring cartoon objects and characters into the third dimension, by giving them the ability to rotate and be viewed from any angle. We show how 2D vector art drawings of a cartoon from different views can be used to generate a novel structure, the 2.5D cartoon model, which can be used to simulate 3D rotations and generate plausible renderings of the cartoon from any view. 2.5D cartoon models are easier to create than a full 3D model, and retain the 2D nature of hand-drawn vector art, supporting a wide range of stylizations that need not correspond to any real 3D shape.
The intestinal barrier as an emerging target in the toxicological assessment of mycotoxins (2016)

Mycotoxins, the secondary metabolites of fungal species, are the most frequently occurring natural food contaminants in human and animal diets. Risk assessment of mycotoxins focused as yet on their mutagenic, genotoxic and potential carcinogenic effects. Recently, there is an increasing awareness of the adverse effects of various mycotoxins on vulnerable structures in the intestines. In particular, an impairment of the barrier function of the epithelial lining cells and the sealing tight junction proteins has been noted, as this could result in an increased translocation of luminal antigens and pathogens and an excessive activation of the immune system. The current review aims to provide a summary of the available evidence regarding direct effects of various mycotoxins on the intestinal epithelial barrier. Available data, based on different cellular and animal studies, show that food-associated exposure to certain mycotoxins, especially trichothecenes and patulin, affects the intestinal barrier integrity and can result in an increased translocation of harmful stressors. It is therefore hypothesized that human exposure to certain mycotoxins, particularly deoxynivalenol, as the major trichothecene, may play an important role in etiology of various chronic intestinal inflammatory diseases, such as inflammatory bowel disease, and in the prevalence of food allergies, particularly in children.