gebhart/patrepeval huggingface dataset:
Bayesian optimization for predicting rare internal failures in manufacturing processes (2016)

Modern manufacturing processes are highly instrumented to capture data at every step along the assembly lines. Such fine-grained data can help manufacturers perform quality control by predicting which manufactured products are at risk of being defective. A predictive analytics system that identifies internal failures in products before they are shipped can result in significant savings for the manufacturer and result in better customer satisfaction. However, predicting internal failures in manufactured products is a challenging machine learning task due to two reasons: (i) the rarity of such failures in modern manufacturing processes, and (ii) the failure of traditional machine learning algorithms to optimize non-convex metrics such as Matthew's Correlation Coefficient (MCC) used to measure performance on imbalanced datasets. In this paper, we present “ImbalancedBayesOpt”, a meta-optimization algorithm that directly maximizes MCC by learning optimal weights for the positive and negative classes. We use Gradient Boosting Machine (GBM) as the base classifier for our meta-optimization algorithm due to its competitive performance on machine learning prediction tasks. Our quantitative evaluation suggests that “ImbalancedBayesOpt” can significantly improve the classification performance of base classifiers on severely imbalanced high-dimensional datasets.
Analysis on the Penetration and Potential of Foreign Direct Investment in Ethnic Provinces and Regions of China (2023)

With the reform and opening up, the utilization of foreign direct investment (FDI) in ethnic provinces and regions of China has started and continued to develop, but its development speed is slower than the national average. The economic penetration and capital penetration of FDI in ethnic provinces and regions are lower than the national level, indicating that FDI in ethnic provinces and regions has not been able to play its due guiding role in its economy and investment. The average performance index of FDI in ethnic provinces and regions is also lower than that of the country, indicating that the potential of FDI has not been fully realized. The construction of the "the Belt and Road" will profoundly change the location disadvantage of ethnic areas and greatly improve the investment environment of ethnic provinces and regions. Ethnic provinces and regions need to take a series of measures to attract high-quality FDI and thus to accelerate the development of the open economy.
N-myc functions in transcription and development (2005)

N-Myc is a member of the Myc family of proteins, which are best known for their potent oncogenic activities and association with a large proportion of human cancers. Intense scrutiny of the oncogenic properties of Myc family proteins over the last several decades has revealed a great deal about their transcriptional and oncogenic activities. Myc proteins have broad effects on transcription and can stimulate a variety of cell behaviors that contribute to the malignant phenotype. N-Myc and c-Myc also play essential functions during embryonic development, and loss of these proteins has deleterious effects in most, if not all, tissues and organ systems. What remains to be fully unraveled is the relationship between the diverse activities associated with deregulated and overexpressed Myc and their normal roles during embryonic development and tissue homeostasis. In this review I summarize our understanding of the transcriptional activities of Myc family proteins and the roles of N-myc in morphogenesis, particularly as they relate to cellular proliferation and apoptosis.
Minimising simple XPath expressions (2001)

We consider a subset of XPath expressions, called simple XPath expressions, which correspond to a class of conjunctive queries. We show that, in the absence of a DTD, each simple XPath expression has a unique minimal equivalent expression which can be found in polynomial time. We then consider D-equivalence, the equivalence of expressions with respect to the set of documents valid for a given DTD D. We show that a simple XPath expression P does not necessarily have a unique minimal D-equivalent expression. However, if P is reduced (there are no wildcards in it), then there is a unique minimal equivalent expression, but we show that deciding whether two reduced expressions are D-equivalent is coNP-hard.
Effect of the length of the alkyl chains in porphyrin meso-substituents on the performance of dye-sensitized solar cells (2013)

A series of novel zinc porphyrin dyes which have a D–π–A structure have been designed and synthesized for DSSC applications. The donors containing a carbazole group in which the carbazole nitrogen is bonded with a butyl, hexyl or decyl chain, had a significant influence on the spectra of the TiO2 films and the electrochemical and photovoltaic properties of these sensitizers. The sensitizer with a hexyl chain (CZ-6) achieved a higher overall conversion efficiency than that with a butyl chain (CZ-4) because of its slower charge recombination rate and faster electron injection from the dye to the conduction band of the conducting glass. Furthermore, the dye with a decyl chain (CZ-10) performed the lowest conversion efficiency, resulting from the least amount of dye loading. This was due to the steric hindrance of the molecule. The highest light-to-electricity conversion efficiency (η) of 2.13% was realized for the dye CZ-6 based DSSC, which was higher than those achieved for the CZ-4- and CZ-6-sensitized DSSCs (1.69% and 1.30% respectively).
Hyperspectral remote sensing of plant pigments (2006)

The dynamics of pigment concentrations are diagnostic of a range of plant physiological properties and processes. This paper appraises the developing technologies and analytical methods for quantifying pigments non-destructively and repeatedly across a range of spatial scales using hyperspectral remote sensing. Progress in deriving predictive relationships between various characteristics and transforms of hyperspectral reflectance data are evaluated and the roles of leaf and canopy radiative transfer models are reviewed. Requirements are identified for more extensive intercomparisons of different approaches and for further work on the strategies for interpreting canopy scale data. The paper examines the prospects for extending research to the wider range of pigments in addition to chlorophyll, testing emerging methods of hyperspectral analysis and exploring the fusion of hyperspectral and LIDAR remote sensing. In spite of these opportunities for further development and the refinement of techniques, current evidence of an expanding range of applications in the ecophysiological, environmental, agricultural, and forestry sciences highlights the growing value of hyperspectral remote sensing of plant pigments.
Alcohol-Related Hospitalizations of Elderly People (1993)

Alcohol-related hospitalizations among elderly people are common; rates were similar to those for myocardial infarction as detected by the same method. The charges to Medicare for this preventable problem are considerable. Ecological analysis suggests that per capita consumption in the total US population predicts alcohol-related hospitalizations in the elderly population.
Highly sensitive torsion sensor based on triangular-prism-shaped long-period fiber gratings (2021)

We propose and investigate a compact optical fiber sensor that aims to measure the torsion in both amount and direction with high sensitivity. This sensor is configured by a triangular-prism-shaped long-period fiber grating, which is fabricated by the high frequency CO2 laser polished method. The unique design of the triangular-shaped structure breaks the rotational symmetry of the optical fiber and provides high sensitivity for torsion measurement. In preliminary experiments, the torsion response of the sensor achieves a good stability and linearity. The torsion sensitivity is 0.54 nm/(rad/m), which renders the proposed structure a highly sensitive torsion sensor.
Scan design in the Philips ASIC test environment (2002)

Increasingly complex ASICs need Design For Testability (DFT) techniques to by-pass the test bottleneck. Among the most popular is scan test. The Philips ASIC Test Environment (PATE) includes tools and libraries for scan test and gives ASIC designers a natural approach to DFT. The Philips Components software tools AMSAL and SIMTAP provide Automatic Test Pattern Generation (ATPG) and testability analysis. The silicon overhead due to the scan technique is minimized by dedicated scan flip-flops in the Philips Components ASIC libraries. The PATE approach ensures high quality test vectors and predictable development time from design capture to automatic test vector generation. This paper briefly recalls the basics of scan techniques and then shows their integration in PATE. It finishes with a practical example.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis of All Eight Stereoisomers of the Germination Stimulant Strigol (2000)

(+)-Strigol is a naturally occurring germination stimulant for the seeds of the parasitic weeds Striga and Orobanche. This paper describes the synthesis of all eight stereoisomers of strigol. The absolute configuration of these stereoisomers has been deduced from their CD-spectra.
Formulation, antibacterial activity, and cytotoxicity of 1‐monoacylglycerol microemulsions (2014)

Antibacterial activity of stable 1‐monoacylglycerol (1‐MAG) microemulsions (MEs) of capric (C10:0), undecanoic (C11:0), lauric (C12:0), and myristic (C14:0) acids against the growth of gram‐positive and gram‐negative bacteria was tested and their inhibition effect was compared to that of neat 1‐MAG. To reveal their behavior with respect to eukaryotic cells, the cytotoxicity on mouse fibroblasts was also determined. The MEs were studied via pseudo‐ternary phase diagrams in order to find out the miscibility areas of all components used. The results indicated that at 1‐MAG concentrations of 1000–1900 mg/L, an inhibition of gram‐negative strains was improved compared to neat 1‐MAG and depended on the fatty acid type; however, at lower 1‐MAG concentrations, both systems showed comparable effect. The opposite trend was detected on gram‐positive bacteria, where 1‐MAGs showed better performance compared to corresponding MEs. The best antibacterial activity against both bacterial types was observed in 1‐MAG C12:0 MEs. MTT assay revealed significant cytotoxicity of all MEs. The threshold of 10 mg/L was determined as the limit for moderate toxicity, which represents 40–60% cell survival. All prepared MEs were transparent, stable during the storage period of 6 months and their particle sizes were between 15 and 20 nm. Practical applications: 1‐MAGs belong to safe and efficient antimicrobial agents and their application may be a convenient alternative to usage of synthetic antimicrobials; however, one of their limitations for certain applications is their insolubility in aqueous systems. This drawback can be reduced by encapsulation of 1‐MAGs in suitable ME system. The presented study has confirmed that 1‐MAG MEs possess suitable inhibitory activity against both gram‐negative and gram‐positive bacteria. Efficacy of MEs against gram‐negative strains was enhanced compared to 1‐MAG alone. Although the growth of gram‐positive bacteria was less affected by MEs when compared to neat 1‐MAG, the results can be closely related to potential industrial applications of the MEs as effective agents for cosmetics, dermatology, food industry, paint or coatings where water‐based systems are frequently used and desired. The application of studied systems might be to some extent limited due to the potential health risk caused by the observed cytotoxicity.
Adherence to Physical Activity Among Older Adults Using a Geographic Information System: Korean National Health and Nutrition Examinations Survey IV (2011)

The majority of older adults did not meet the national PA recommendations, suggesting that consistent surveillance and intervention for PA in the geriatric population are needed in the future. Maps generated using GIS visually showed regional differences in PA among the study participants.
U.S. Imports of Concentrated Milk Proteins: What We Know and Don't Know? (2003)

Imported milk protein has, once again, become a hot button in the U.S. dairy industry. The current controversy concerns Milk Protein Concentrate (MPC). Imports of MPC, a relatively new form of concentrated dairy-based protein, increased rapidly in the late 1990s, leading to charges that dairy farmers were being economically penalized. Bills were introduced in both the U.S. House and Senate in 2001 to restrict imports through the application of over-quota tariffs. A Senate bill to require special labeling of products manufactured from imported MPC has already been introduced in the 108 th Congress. The issue of border controls for imports of concentrated milk proteins dates back more than 20 years and probably much longer. In 1979, the Agriculture Committee of the U.S. Senate conducted hearings on the issue of whether increased imports of casein had reduced domestic use of nonfat dry milk and eleva ted the cost of the dairy price support program (Graf). This led to an investigation of casein imports by the U.S. International Trade Commission in 1980. The 1985 Food Security Act mandated USDA to conduct a study to determine whether imports of casein reduced the effectiveness of the dairy price support program. None of these actions resulted in import restrictions — concentrated milk proteins are and have been imported into the United States without quotas and with only inconsequential duties. This paper provides a broad perspective on the milk protein import issue. It proceeds as a series of questions related to the nature and uses of the products imported, trends in import volume and sources, and effects of imports. The intent is to sort out what we know from what we don’t know about imported milk proteins.
The Effect of Zeaxanthin as the Only Xanthophyll on the Structure and Function of the Photosynthetic Apparatus in Arabidopsis thaliana (2004)

In green plants, the xanthophyll carotenoid zeaxanthin is synthesized transiently under conditions of excess light energy and participates in photoprotection. In the Arabidopsis lut2 npq2 double mutant, all xanthophylls were replaced constitutively by zeaxanthin, the only xanthophyll whose synthesis was not impaired. The relative proportions of the different chlorophyll antenna proteins were strongly affected with respect to the wild-type strain. The major antenna, LHCII, did not form trimers, and its abundance was strongly reduced as was CP26, albeit to a lesser extent. In contrast, CP29, CP24, LHCI proteins, and the PSI and PSII core complexes did not undergo major changes. PSII-LHCII supercomplexes were not detectable while the PSI-LHCI supercomplex remained unaffected. The effect of zeaxanthin accumulation on the stability of the different Lhc proteins was uneven: the LHCII proteins from lut2 npq2 had a lower melting temperature as compared with the wild-type complex while LHCI showed increased resistance to heat denaturation. Consistent with the loss of LHCII, light-state 1 to state 2 transitions were suppressed, the photochemical efficiency in limiting light was reduced and photosynthesis was saturated at higher light intensities in lut2 npq2 leaves, resulting in a photosynthetic phenotype resembling that of high light-acclimated leaves. Zeaxanthin functioned in vivo as a light-harvesting accessory pigment in lut2 npq2 chlorophyll antennae. As a whole, the in vivo data are consistent with the results obtained by using recombinant Lhc proteins reconstituted in vitro with purified zeaxanthin. While PSII photoinhibition was similar in wild type and lut2 npq2 exposed to high light at low temperature, the double mutant was much more resistant to photooxidative stress and lipid peroxidation than the wild type. The latter observation is consistent with an antioxidant and lipid protective role of zeaxanthin in vivo.
Building a cognitive platform for the managed IT services lifecycle (2018)

In this paper, we present IBM's cognitive strategy for service delivery transformation to a services integration approach for IT service management. This transformation is fueled by three fundamental technological paradigms: cognitive, cloud, and data and digital content. At the foundation of this approach is the IBM Services Platform with Watson—an IBM Cloud and Watson-based platform that uses machine learning, natural language, discovery, and various Watson application programming interfaces to design superior client solutions, achieve an exceptional level of autonomic service management, and facilitate a healthy “always-on” environment. It continuously learns and optimizes information technology performance to enable enhanced client business outcomes.
Review of scientific project Prevention of behavior disorders in local community (2004)

By now we could say that the twentieth century was “ the century of the child” and perhaps no other era has ever positioned the “ child” so high. Ideas and intentions in many world programs and proclamations such as “ society focused on children” or “ communities that care” (Hawkins, Catalano, 1992) have put the “ child” and the “ child needs” forward. Despite all no other century has left so many open questions such as: how to decrease an area of danger and risk factors in development of youth or how to increase the areas of strength and competencies in youth as a base of increasing their resilience in existing individual risk and potentially dangerous environments. General speaking there is more and more evident and growing perception (public and professional) of increasing and worsening problems in children and youth. Recent research of the efficiency of preventive and treatment interventions towards children and youth with behavior disorders have suggested the change of course in interventions from pathology and risk to the strengths and competencies of an individual and his environment. The goal of this poster is to present the backgruond of this project. Main aim of prezented research is finding the model that would simultaneously be described thought positive development of young person, strengthening families, schools, and caring communities, as well as promote health, education and protection. The starting point in this research is the hypothesis that there are many risk and protective factors which play an important part in the progression of behavior disorders in children and youth, allot which are at the level of a child, young adult, family, school and local community. Considering that the research will be carried out in one county (Istria) we expect the results which will enable the implementation on that area as well as the transfer of experience to other communities together with the necessary modification, supervision and evaluation. The sample comprises elementary and high school children, their parents/families, teacher and other professional stuff and key persons in the community. By multivariate processing of information the correct conclusion about the carried out research will be available. This research will lay out the foundations to national strategy of the Republic of Croatia for prevention of behavior disorder in children and youth.
Nematodes and regulatory T cells. (2013)

This chapter focuses on regulatory T cells and their role in human nematode infections. The function of regulatory T cells in mouse models and human studies of filarial (Brugia malayi, Litomosoides sigmodontis) and intestinal (Heligmosomoides polygyrus, Strongyloides stercoralis, Ascaris lumbricoides, Trichuris, Trichinella spiralis, etc.) nematode infections, and the role of Tr1 and IL-10 in nematode infections are described. The induction of regulatory T cells and the potential of helminth therapy in autoimmune conditions are discussed.
ssDNA Templated Self-Assembly of Chromophores (2007)

A single strand of DNA templates a supramolecular strand of chromophores, yielding a new type of DNA hybrid. In this hybrid construct, an oligothymine is used as the template to which a supramolecular stack of naphthalenes or oligo(phenylene)vinylenes equipped with a complementary diamino triazine unit is hydrogen-bonded.
Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress (2009)

Oxidative stress is suggested to play a key role in the development of cardiac hypertrophy and fibrosis in CKD. AST-120 may suppress oxidative stress and reduce cardiac damage in CKD.
Cross-Domain Recommendation via Clustering on Multi-Layer Graphs (2017)

Venue category recommendation is an essential application for the tourism and advertisement industries, wherein it may suggest attractive localities within close proximity to users' current location. Considering that many adults use more than three social networks simultaneously, it is reasonable to leverage on this rapidly growing multi-source social media data to boost venue recommendation performance. Another approach to achieve higher recommendation results is to utilize group knowledge, which is able to diversify recommendation output. Taking into account these two aspects, we introduce a novel cross-network collaborative recommendation framework C3R, which utilizes both individual and group knowledge, while being trained on data from multiple social media sources. Group knowledge is derived based on new cross-source user community detection approach, which utilizes both inter-source relationship and the ability of sources to complement each other. To fully utilize multi-source multi-view data, we process user-generated content by employing state-of-the-art text, image, and location processing techniques. Our experimental results demonstrate the superiority of our multi-source framework over state-of-the-art baselines and different data source combinations. In addition, we suggest a new approach for automatic construction of inter-network relationship graph based on the data, which eliminates the necessity of having pre-defined domain knowledge.
Silibilin-Induces Apoptosis in Breast Cancer Cells by Modulating p53, p21, Bak and Bcl-xl Pathways (2015)

Nowadays herbal-derived medicines are attracting attention as new sources of drugs with few side effects. Silibinin is a flavonoid compound with chemotheraputic effects on different cancers such as examples in the prostate, lung, colon and breast. In the present study, the cytotoxic effects of silibinin on MCF7 breast cancer cells were investigated. Apoptosis was determined by flow cytometry and the impact of silibinin on the expression of pivotal genes including Bak, P53, P21, BRCA1, BCL-X1 and ATM was analyzed. Treatment for 24h had a significant dose-dependent inhibitory effect on cell growth (p<0.05) with dose- and time- dependent induction of apoptosis (p<0.05). In addition, there were significant increases in BRCA1, ATM, Bak and Bcl-XL gene expression at the mRNA level with different concentrations of silibinin for 24 or 48 h (p<0.05). Taken together, the results suggest that silibinin inhibits the proliferation and induces apoptosis of MCF-7 cells by down-regulating Bak, P53, P21, BRCA1, BCL-Xl and thus may be considered as an effective adjuvant drug to produce a better chemopreventive response for the cancer therapy.
Active clamps with hybrid BJT-CMOS operation mode (2015)

A method to exploit the internal gain of the parasitic bipolar transistor in integrated LDMOS devices achieving a mixed bipolar-CMOS regime is proposed and validated using numerical simulation and experimental results. An improvement of active protection clamps in ESD component, HMM, and surge operation regime is demonstrated. The same principle for NLDMOS device in mixed bipolar-CMOS in linear regime is further demonstrated and applied for power stages.