gebhart/patrepeval huggingface dataset:
Epitopes of human fibrin recognized by the rheumatoid arthritis‐specific autoantibodies to citrullinated proteins (2006)

Formation of the epitopes recognized by the rheumatoid arthritis (RA)-specific autoantibodies to citrullinated proteins (ACPA) on filaggrin and on the alpha- and beta-chains of fibrin, their synovial target, requires conversion of their arginyl residues into citrullyl residues, but is also affected by their amino-acyl environment. Using competition with five citrullinated filaggrin-derived peptides bearing major ACPA epitopes, we confirmed the close cross-reactivity between filaggrin and citrullinated fibrin. To identify the sequential epitopes recognized on fibrin by ACPA, 71 citrullinated 15-mer peptides derived from all the sites of the alpha- and beta-chains of fibrin harboring arginyl residues were tested by ELISA using ACPA-positive RA sera exhibiting different reactivity profiles to the five filaggrin peptides. We identified 18 fibrin-derived peptides bearing ACPA epitopes. Regarding the ability of fibrinogen arginyl residues to be citrullinated in vitro, 11 of the peptides likely correspond to in vivo targeted epitopes. Two out of them bear major epitopes and are located in the central globular domain of the protein. In the synovial tissue, fibrin citrullination and ACPA binding could impair fibrin degradation by plasmin. The immunological conflict between ACPA and fibrin could therefore sustain synovial inflammation not only via pro-inflammatory effector mechanisms but also via impairment of fibrinolysis.
Self-adaptive correlation method for soft defect detection in cable by reflectometry (2014)

The self-adaptive correlation method (SACM), based on a temporal processing, consists in treating the reflectogram in order to amplify the signatures of soft defects and make them more easily detectable. The algorithm amplifies any signature correlated with the injection pulse. Amplification is more important as the amplitude of the soft defect is low, and reciprocally. Thus, this method allows to highlight the soft defect while attenuating the noise present on the reflectogram. The term “self-adaptive” means that the gain is automatically adjusted depending on the amplitude of the soft defect signature. This method is applicable to different reflectometry techniques with different waveforms and different position of the defect in the cable. This innovative approach has the advantage of reducing the computational complexity compared to the state of the art.
IFS: Intelligent flow sampling for network security–an adaptive approach (2015)

Summary In order to cope with an increasing volume of network traffic, flow sampling methods are deployed to reduce the volume of log data stored for monitoring, attack detection and forensic purposes. Sampling frequently changes the statistical properties of the data and can reduce the effectiveness of subsequent analysis or processing. We propose two concepts that mitigate the negative impact of sampling on the data. Late sampling is based on a simple idea that the features used by the analytic algorithms can be extracted before the sampling and attached to the surviving flows. The surviving flows thus carry the representation of the original statistical distribution in these attached features. The second concept we introduce is that of adaptive sampling. Adaptive sampling deliberatively skews the distribution of the surviving data to over‐represent the rare flows or flows with rare feature values. This preserves the variability of the data and is critical for the analysis of malicious traffic, such as the detection of stealthy, hidden threats. Our approach has been extensively validated on standard NetFlow data, as well as on HTTP proxy logs that approximate the use‐case of enriched IPFIX for the network forensics. Copyright © 2015 John Wiley & Sons, Ltd.
Intraspecies Genomic Diversity and Natural Population Structure of the Meat-Borne Lactic Acid Bacterium <i>Lactobacillus sakei</i> (2008)

Lactobacillus sakei is a food-borne bacterium naturally found in meat and fish products. A study was performed to examine the intraspecies diversity among 73 isolates sourced from laboratory collections in several different countries. Pulsed-field gel electrophoresis analysis demonstrated a 25% variation in genome size between isolates, ranging from 1,815 kb to 2,310 kb. The relatedness between isolates was then determined using a PCR-based method that detects the possession of 60 chromosomal genes belonging to the flexible gene pool. Ten different strain clusters were identified that had noticeable differences in their average genome size reflecting the natural population structure. The results show that many different genotypes may be isolated from similar types of meat products, suggesting a complex ecological habitat in which intraspecies diversity may be required for successful adaptation. Finally, proteomic analysis revealed a slight difference between the migration patterns of highly abundant GapA isoforms of the two prevailing L. sakei subspecies (sakei and carnosus). This analysis was used to affiliate the genotypic clusters with the corresponding subspecies. These findings reveal for the first time the extent of intraspecies genomic diversity in L. sakei. Consequently, identification of molecular subtypes may in the future prove valuable for a better understanding of microbial ecosystems in food products.
Biosynthesis of Terpenes. Preparation of (<i>E</i>)-1-Hydroxy-2-methyl-but-2-enyl 4-Diphosphate, an Intermediate of the Deoxyxylulose Phosphate Pathway (2002)

(E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate (E-6) was synthesized in six reaction steps from hydroxyacetone (9) and (ethoxycarbonylmethenyl)-triphenylphosphorane (11) with an overall yield of 38%. The compound was shown to be identical with the product of IspG protein, which serves as an intermediate in the nonmevalonate terpene biosynthetic pathway.
Sensor-trigger device for explosion barrier (1979)

A flame sensor-trigger device was developed for use with barriers to suppress coal dust explosions in undergound mines. Principal feature of the device is a dual infrared flame sensor combined with a pressure-arming element. This combination prevents false and premature triggering of the barrier. With minor modifications, the device can also be used with barriers for protection in other facilities against gas explosions and explosions involving dusts other than coal.
Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells. (1999)

The current options for treating breast cancer are limited to excision surgery, general chemotherapy, radiation therapy, and, in a minority of breast cancers that rely on estrogen for their growth, antiestrogen therapy. The naturally occurring chemical indole-3-carbinol (I3C), found in vegetables of the Brassica genus, is a promising anticancer agent that we have shown previously to induce a G1 cell cycle arrest of human breast cancer cell lines, independent of estrogen receptor signaling. Combinations of I3C and the antiestrogen tamoxifen cooperate to inhibit the growth of the estrogen-dependent human MCF-7 breast cancer cell line more effectively than either agent alone. This more stringent growth arrest was demonstrated by a decrease in adherent and anchorage-independent growth, reduced DNA synthesis, and a shift into the G1 phase of the cell cycle. A combination of I3C and tamoxifen also caused a more pronounced decrease in cyclin-dependent kinase (CDK) 2-specific enzymatic activity than either compound alone but had no effect on CDK2 protein expression. Importantly, treatment with I3C and tamoxifen ablated expression of the phosphorylated retinoblastoma protein (Rb), an endogenous substrate for the G1 CDKs, whereas either agent alone only partially inhibited endogenous Rb phosphorylation. Several lines of evidence suggest that I3C works through a mechanism distinct from tamoxifen. I3C failed to compete with estrogen for estrogen receptor binding, and it specifically down-regulated the expression of CDK6. These results demonstrate that I3C and tamoxifen work through different signal transduction pathways to suppress the growth of human breast cancer cells and may, therefore, represent a potential combinatorial therapy for estrogen-responsive breast cancer.
High-temperature interband cascade lasers emitting in the 2.9-4.2 &#x03BC;m wavelength range (2008)

This paper reports an evaluation of carrier lifetimes and Auger coefficients for numerous interband cascade lasers (ICLs) emitting over a large part of the midinfrared spectrum. The lifetimes and Auger coefficients are extracted by correlating the measured pulsed threshold current densities and slope efficiencies of broad-area ICLs with calculations of optical gain vs. carrier density in the active region. Results show that the improved properties that led to room-temperature cw operation are similarly available in devices spanning the spectral window of at least 2.9-4.2 mum.
Digital libraries and autonomous citation indexing (1999)

The revolution the Web has brought to information dissemination is not so much due to the availability of data-huge amounts of information has long been available in libraries-but rather the improved efficiency of accessing (improved accessibility to) that information. The Web promises to make more scientific articles more easily available. By making the context of citations easily and quickly browsable, autonomous citation indexing can help to evaluate the importance of individual contributions more accurately and quickly. Digital libraries incorporating ACI can help organize scientific literature and may significantly improve the efficiency of dissemination and feedback. ACI may also help speed the transition to scholarly electronic publishing.
Serum Trypsinogen-2 in the Prediction of Outcome in Acute Necrotizing Pancreatitis (1996)

The immunofluorometric assay of serum trypsinogen-2 is a sensitive and specific method for prediction of the severity of the disease in necrotizing pancreatitis.
Noncontact two-color luminescence thermometry based on intramolecular luminophore cyclization within an ionic liquid (2003)

A self-referencing optical thermometer based on a reversible, temperature-dependent monomer-excimer interconversion of 1,3-bis(1-pyrenyl)propane dissolved in an ionic liquid and operating in the 25 to 140 degrees C range is reported.
Variable Stiffness Mechanism for Tremor Suppression in Human-Robot Interaction (2018)

Variable stiffness mechanisms have a wide range of applications in the field of human-robot interactions such as rehabilitation robotics, prosthesis and industrial robotics due to their ability to comply with the human limb stiffness in an unstructured environment. This paper presents the analysis of a single degree of freedom variable stiffness actuator based on nonlinear force interactions between permanent magnets and its effect on the natural frequency of the system. In the proposed mechanism, variable stiffness is achieved by modifying the separation between magnets. The main goal here is to achieve a desired cutoff frequency by varying the stiffness of the system to filter out the involuntary movement of upper limb during physical human-robot interactions. Moreover, due to the spring-like non-contact force interactions between magnets, this mechanism can prevent the exchange of high impact forces between the robot and human.
Comprehensive statistical admission control for streaming media servers (2003)

Streaming media servers and digital continuous media recorders require the scheduling of I/O requests to disk drives in real time. There are two accepted paradigms to achieve this: deterministic or statistical. The deterministic approach must assume larger bounds on such disk parameters as the seek time, the rotational latency and the transfer rate, to guarantee the timely service of I/O requests. The statistical approach generally allows higher utilization of resources, in exchange for a residual probability of missed I/O request deadlines. We propose a novel statistical admission control algorithm called TRAC based on a comprehensive three random variable (3RV) model to support both reading and writing of multiple variable bit rate media streams on current generation disk drives. Its major distinctions from previous work include (1) a very realistic disk model which considers multi-zoning of disks, seek and rotational latency profiles, and unequal reading and writing data rate limits, (2) a dynamic bandwidth sharing mechanism between reading and writing, and (3) support for random placement of data blocks. We evaluate the TRAC algorithm through an extensive numerical analysis and real device measurements. The results show that it achieves a much more realistic resource utilization (up to 38\% higher) as compared with the best, previously proposed algorithm based on a single random variable (1RV) model. Most impressive, in all the experiments the difference between the results generated by TRAC and the actual disk device measurements match closely.
Thin film silicon solar cell and module (2005)

We have been developed a new light trapping scheme for thin film Si stacked module (Si HYBRID PLUS module), where a-Si:H/transparent inter-layer/microcrystalline Si thin film integrated large area solar cell module. An initial aperture efficiency of 13.1% has been achieved for 910/spl times/455 mm/sup 2/ Si HYBRID PLUS module, which was independently confirmed by AIST. This is the first time report for independently confirmed efficiency of large area thin film Si module with interlayer. The 19% increase of short circuit current (I/sub sc/) of this module was obtained by the introduction of transparent interlayer, namely internal light trapping. Stabilized efficiency of mini module exhibited the 12%. Outdoor performances of Si HYBRID (a-Si:H/micro-crystalline Si stacked) solar cell module have been investigated over 4 years for two different kind of modules (top and bottom cell limited, respectively). The Hybrid modules limited by the top cell have exhibited the more efficient performance rather than the bottom limited in natural sunlight at noon.
Characterizing illumination angular uniformity with phase-shifting masks (2003)

A phase shifting mask pattern consisting of a linear phase grating is introduced as a potential tool to measure or monitor illumination angular distribution and uniformity in optical projection printing. An implementation as simple as four phase steps serves to steer the illumination into and out of the pupil at an angle determined by the period of the grating. The total intensity captured within the pupil is recorded in resist, allowing for a fast analysis of the illuminator’s fill of the pupil. The advantage over existing techniques lies in the fact that the analysis of the source has been transferred to the design of the mask pattern. A cursory inspection of a single dose-matrix wafer with a low magnification optical microscope readily displays signs of source irregularity. If signs of irregularity exist, the capability exists for the user to complete a more in-depth analysis of the source intensity distribution. Illumination pupil-fill is easily monitored across the field, tool-to-tool, or over time, or can be compared to the intended design. Due to mask simplicity, this technique is especially useful for monitoring quadrupole or quasar illuminators. Mask requirements are discussed, concluding that with an average grating period of 2μm and tolerance of up to 40nm layer to layer overlay error, fabrication appears feasible.
Synthesis and characterization of diallyl telluride and allyl methyl telluride (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of diallyl telluride and allyl methyl tellurideKelvin T. Higa and Daniel C. HarrisCite this: Organometallics 1989, 8, 7, 1674–1678Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/om00109a016https://doi.org/10.1021/om00109a016research-articleACS PublicationsRequest reuse permissionsArticle Views353Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wake Vortex Alleviation Using Rapidly Actuated Segmented Gurney Flaps (2007)

A study to assess the potential for using rapidly actuated segmented Gurney flaps, also known as miniature trailing-edge effectors, for active wake vortex alleviation is conducted. Experiments are performed using a half-span model wing with NACA 0012 shape and an aspect ratio of 4.1. The wing is at an 8.9-deg angle of attack and the chord-based Reynolds number is around 350,000. It is equipped with an array of miniature trailing-edge effectors that extend 0.015 chord lengths perpendicular to the freestream on the pressure side of the wing when deployed and sit just behind the blunt trailing edge when retracted. Measurements of section lift coefficient and the velocity field in the intermediate wake using dynamic particle image velocimetry and a five-hole probe delineate the time-varying perturbation imparted by the miniature trailing-edge effectors upon the trailing vortex while keeping the lift nearly constant. The data are used to form a complete initial condition for a vortex filament computation of the far-wake evolution. Cases at the model-scale and full-scale configurations are computed
Deep Clonal Profiling of Formalin Fixed Paraffin Embedded Clinical Samples (2012)

Formalin fixed paraffin embedded (FFPE) tissues are a vast resource of annotated clinical samples. As such, they represent highly desirable and informative materials for the application of high definition genomics for improved patient management and to advance the development of personalized therapeutics. However, a limitation of FFPE tissues is the variable quality of DNA extracted for analyses. Furthermore, admixtures of non-tumor and polyclonal neoplastic cell populations limit the number of biopsies that can be studied and make it difficult to define cancer genomes in patient samples. To exploit these valuable tissues we applied flow cytometry-based methods to isolate pure populations of tumor cell nuclei from FFPE tissues and developed a methodology compatible with oligonucleotide array CGH and whole exome sequencing analyses. These were used to profile a variety of tumors (breast, brain, bladder, ovarian and pancreas) including the genomes and exomes of matching fresh frozen and FFPE pancreatic adenocarcinoma samples.
Polyenylcyclopropane carboxylic esters with high insecticidal activity (2014)

Novel pyrethroid derivatives obtained from 2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylic acid are described. These derivatives display high insecticidal activity, a wide spectrum of action and no toxicity towards mammalians. The proposed synthetic procedures are highly efficient and inexpensive, and therefore suitable for industrial scale-up.
Amorphous Metal Fluoride Passivation Coatings Prepared by Atomic Layer Deposition on LiCoO<sub>2</sub> for Li-Ion Batteries (2015)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTAmorphous Metal Fluoride Passivation Coatings Prepared by Atomic Layer Deposition on LiCoO2 for Li-Ion BatteriesJoong Sun Park†, Anil U. Mane‡, Jeffrey W. Elam‡, and Jason R. Croy*†View Author Information† †Chemical Sciences and Engineering Division and ‡Energy Systems Division, Argonne National Laboratory, Argonne, Illinois 60439, United States*E-mail: [email protected]Cite this: Chem. Mater. 2015, 27, 6, 1917–1920Publication Date (Web):March 5, 2015Publication History Received21 November 2014Revised3 March 2015Published online11 March 2015Published inissue 24 March 2015https://doi.org/10.1021/acs.chemmater.5b00603Copyright © 2015 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views3169Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Atomic layer deposition,Coating materials,Deposition,Electrodes,Materials Get e-Alerts
Linkage of the PvuII polymorphism with the common Jewish mutation for Gaucher disease. (1990)

We have localized the PvuII polymorphism of the glucocerebrosidase gene complex to intron 6 of the active gene. Using the polymerase chain reaction (PCR) to amplify intron 6 of DNA samples from Pv1.1-/Pv1.1+ individuals, we defined the mutation causing this polymorphism as a G----A single-base substitution at position 3931 of the active gene. By analyzing 54 unrelated Gaucher patients we show strong linkage disequilibrium between the Pv1.1- genotype and the common Jewish mutation 1226 causing the adult type of this disease. Gaucher disease patients heterozygous for the 1226 allele and one unidentified allele (1226/?), particularly those of Jewish ancestry, were predominantly of the Pv1.1-/PV1.1+ genotype. This suggests that one of the unknown alleles may be relatively common and linked to the Pv1.1+ genotype.
Deep learning-based image quality improvement of 18F-fluorodeoxyglucose positron emission tomography: a retrospective observational study (2021)

Deep learning method improves the quality of PET images.