gebhart/patrepeval huggingface dataset:
The DNA Replication Initiation Machinery as a Target for Cancer Diagnosis and Therapy (2011)

Cancer is a leading cause of death worldwide. Early, accurate detection of\nmalignancy leads to better treatment decisions and there is consequently\nan urgent need for new cancer biomarkers. This thesis explores the use of\nthe DNA replication initiation machinery as a target for the development\nof molecular biomarkers able to provide diagnostic and prognostic\ninformation in the clinical setting and to guide treatment decisions. In a\nlarge scale multicentre study, the DNA replicative helicase protein Mcm5\nis shown to be a sensitive and specific biomarker for bladder cancer\ndetection. Further clinical studies demonstrate that Mcm5 is potentially\nuseful for the detection of prostate and pancreaticobiliary tract cancers.\nIn conjunction with markers of mitotic progression and DNA ploidy status,\nreplication initiation proteins are also shown to be able to provide\nprognostic information in the context of penile cancer. Mcm5 is a\ncomponent of the DNA replicative helicase, which is phosphorylated by the\ncell cycle kinase Cdc7 as a crucial step during DNA replication\ninitiation. The work described here demonstrates that depletion of Cdc7 in\na normal human diploid cell line induces a novel origin activation\ncheckpoint at the core of which there are a number of tumour suppressor\nand proto-oncogene proteins that are freq
Smooth invariant interpolation of rotations (1997)

We present an algorithm for generating a twice-differentiable curve on the rotation group SO(3) that interpolated a given ordered set of rotation matrices at their specified knot times. In our approach we regard SO(3) as a Lie group with a bi-invariant Riemannian metriac, and apply the coordinate-invariant methods of Riemannian geometry. The resulting rotation curve is easy to compute, invariant with respect to fixed and moving reference frames, and also approximately minimizes angular acceleration.
Instructor immediacy in the Chinese college classroom (1998)

The purpose of this study was to examine instructor immediacy in the Chinese and American classrooms, and its relationship with Chinese student learning. Participants were 302 undergraduate university students (140 Chinese students enrolled at Peking University in Beijing, China; 162 American students enrolled at a large Midwestern university). Results indicated that (a) Chinese students who received instruction from Chinese instructors perceived a lower amount of instructor nonverbal immediacy than American students who received instruction from American instructors, (b) Chinese students who received instruction from Chinese instructors perceived a lower amount of instructor verbal immediacy than American students who received instruction from American instructors, and (c) perceived Chinese student affective and cognitive learning is slightly correlated with particular Chinese instructor nonverbal and verbal immediacy behaviors.
Can detection of Braf p.V600E mutation be improved? Comparison of allele specific multiplex sequencing to present tests (2017)

Objective: This is an investigative study to evaluate a new companion diagnostic platform, allele specific multiplex sequencing(ASMS). Detection of Braf p.V600E from solid tumors is used as the test model with the following objectives: 1) whether ASMScan detect Braf p.V600E/K mutations from a variety of solid tumors, 2) whether ASMS can detect all Braf p.V600E from samplesthat were positive for Braf V600E by SNaPshot or Ion Torrent, and 3) whether ASMS can detect Braf p.V600E among samplesthat were reported negative by SNaPshot or Ion Torrent.Methods: ASMS is a novel modification (US Patent 6197510) of traditional Sanger sequencing, with Lower Limit of Detection(LLOD) of 20 GE (Genome Equivalent) and 0.001% sensitivity. We compared ASMS to clinical samples previously tested eitherby SNaPshot or Ion Torrent methods.Results: We analyzed 83 DNA extracts from FFPE samples (41 tested by SNaPshot and 42 tested by Ion Torrent). There was atotal of thirty-seven samples positive for Braf p.V600E (16 by Ion Torrent; 21 by SNaPshot), and all of these samples testedpositive by ASMS for Braf p.V600E. Out of the 46 negatives for Braf p.V600E (20 by SNaPshot; 26 by Ion Torrent samples),ASMS detected Braf p.V600E positive results in 10 of the SNaPshot and in 18 of the Ion Torrent negative samples. ASMS coulddetect both Braf p.V600E and the wild-type Braf p.V600 simultaneously with 40pg of FFPE DNA extracts.Conclusions: ASMS assay detected all Braf p.V600E positives from different types of solid tumors that previously tested positiveby SNaPshot or Ion Torrent. Further, ASMS was able to detect Braf p.V600E among samples that were reported negative bySNaPshot or Ion Torrent.
Plasmin potentiates induction of nitric oxide synthesis by interleukin-1 beta in vascular smooth muscle cells (1993)

Experiments were performed to examine the effect of the major fibrinolytic protease, plasmin, on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured human and rat aortic smooth muscle cells. Incubation of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite and nitrate in the culture media. Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. This potentiating effect was abolished when plasmin was incubated with the protease inhibitor, alpha 2-antiplasmin. The perfusates from columns containing IL-1 beta-treated smooth muscle cells relaxed detector blood vessels without endothelium, and the addition of IL-1 beta-treated smooth muscle cells to suspensions of indomethacin-treated platelets inhibited their aggregation. Untreated smooth muscle cells or cells treated with plasmin alone did not have such effects. However, the simultaneous treatment of smooth muscle cells with IL-1 beta and plasmin markedly enhanced both the relaxing activities of the perfusates and the inhibition of platelet aggregation. Treatment of smooth muscle cells with NG-nitro-L-arginine inhibited the cytokine-mediated effects as well as the potentiating effect of plasmin. These results demonstrate that the plasmin can enhance the production of nitric oxide by IL-1 beta-treated vascular smooth muscle cells.
Anomaly Detection In Cellular Network Data Using Big Data Analytics (2014)

Anomaly detection is a key component in which perturbations from a normal behavior suggests a misconfigured/ mismatched data in related systems. In this paper, we present a call detail record based anomaly detection method (CADM) that analyzes the users's calling activities and detects the abnormal behavior of user movements in a real cellular network. CADM is capable of detecting the location of the site that an anomaly has occurred. We evaluate the proposed CADM by performing experiments over the call-detail records of AVEA, a mobile service provider in Turkey.
Guaranteeing fairness and protection in ABR by means of fair queueing (2003)

We propose a new switch algorithm for the support of the available bit rate service category based on fair queueing cell scheduling. We have developed a mechanism to estimate the fair rate for each connection from the bandwidth allocated by the scheduling algorithm at the switch port. The most important advantage of this solution is that fair scheduling enforces fairness and protection. We present simulation results showing that this algorithm is efficient, fair and stable. Furthermore, it allows the allocation of available bandwidth according to various fairness criteria other than the max-min criterion.
Clinical observation on treatment of gastric cancer with Zhijing Granules: a report of 148 cases (2006)

The application of the laser welding technique can prevent the break of the base plate when partial dint increase because of the increase of the magnetic attachments.
Development of Multi-Pixel Photon Counters (2006)

The multipixel photon counter (MPPC) is a newly developed photodetector with an excellent photon counting capability. It also has many attractive features such as small size, high gain, low operation voltage and power consumption, and capability of operating in magnetic fields and in room temperature. The basic performance of samples has been measured. A gain of ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> is achieved with a noise rate less than 500 kHz with 1 p.e. threshold, and cross-talk probability of less than 40% at room temperature. The photon detection efficiency for green light is twice or more that of the photomultiplier tubes. It is found that the basic performance of the MPPC is satisfactory for use in real experiments.
Peran Lurah Dalam Membina Pemuda (2019)

Peran Kepala Kelurahan dalam membina Pemuda di Kelurahan Fatukbot Kecamatan Atambua Selatan Kabupaten Belu. Membina pemuda untuk tercapainya kerukunan dengan warga masyarakat sekitarnya perlu diawali dengan meningkatkan kerukunan dalam kelompok sendiri, bahkan sebagaiknya dimulai dari diri sendiri. Yaitu artinya sulit membina kerukunan dengan masyarakat sekitar khususnya para pemuda sekitar kalau dilingkungan sendiri tidak ada kerukunan. Lokasi penelitian di Kelurahan Fatukbot, Kecamatan Atambua Selatan, Kabupaten Belu. Penelitian ini menggunakan pendekatan kualitatif dan jenis penelitian studi kasus. Data dikumpulkan melalui wawancara, observasi, dan dokumentasi. Hasil penelitian: (1) Memberikan pelatihan kepada para pemuda. (2) Memberikan pembinaan secara terus menerus kepada para pemuda. Dapat disimpulkan bahwa: faktor yang mendukung pembinaan pemuda di Kelurahan Fatukbot: (1) Sosialisasi tentang menjaga ketertiban masyarakat khususnya bagi para pemuda. (2) Melakukan pencegahan atau peneguran. (3) Orang tua. Kendalam dalam pembinaan pemuda di Kelurahan Fatukbot: (1) Sulit dalam mengumpulkan para pemuda secar keseluruhan. (2) Faktor pendidikan. peran kepala lurah dalam membina pemuda di Kelurahan Fatukbot: memotivasi para pemuda untuk aktif dalam mengikuti pelatihan dan pembinaan untuk tercapainya suatu kerukunan dalam masyarakat.
Dopamine and Memory: Modulation of the Persistence of Memory for Novel Hippocampal NMDA Receptor-Dependent Paired Associates (2010)

Three experiments investigated the role in memory processing of dopamine (DA) afferents to the hippocampus (HPC) that arise from the ventral tegmental area. One hypothesis is that D(1)/D(5) receptor activation in HPC is necessary for the encoding of novel, episodic-like information; the other is that DA activation ensures the greater temporal persistence of transient hippocampal memory traces. Rats (n = 35) were trained, in separate experiments using an episodic-like memory task, to learn six paired associates (PAs) in an "event arena" involving a repeated association between specific flavors of food and locations in space. After 6 weeks of training, rats had learned a "schema" such that two new paired associates could be acquired in a single trial in one session (episodic-like memory). We show that encoding of novel PAs is sensitive to intrahippocampal microinfusion of the NMDA antagonist d-AP-5. Experiment 1 established that intrahippocampal infusion of the D(1)/D(5) dopaminergic antagonist SCH23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride] before encoding of new PAs caused impaired memory 24 h later but that SCH23390 had no effect on the later memory of previously established PAs. Experiment 2 established that SCH23390 modulated the persistence of new memories over time (30 min vs 24 h) rather than affecting initial encoding. Experiment 3 revealed that the impact of SCH23390 was not mediated by state dependence nor had an effect on memory retrieval. These findings support the second hypothesis and establish that persistent, long-term memory of rapid, hippocampal-mediated acquisition of new paired associates requires activation of D(1)/D(5) receptors in HPC at or around the time of encoding.
TSGene: a web resource for tumor suppressor genes (2012)

Tumor suppressor genes (TSGs) are guardian genes that play important roles in controlling cell proliferation processes such as cell-cycle checkpoints and inducing apoptosis. Identification of these genes and understanding their functions are critical for further investigation of tumorigenesis. So far, many studies have identified numerous TSGs and illustrated their functions in various types of tumors or normal samples. Furthermore, accumulating evidence has shown that non-coding RNAs can act as TSGs to prevent the tumorigenesis processes. Therefore, there is a growing demand to integrate TSGs with large-scale experimental evidence (e.g. gene expression and epigenetic signatures) to provide a comprehensive resource for further investigation of TSGs and their molecular mechanisms in cancer. To achieve this goal, we first developed a comprehensive literature-based database called TSGene (tumor suppressor gene database), freely available at http://bioinfo.mc.vanderbilt.edu/TSGene/. In the current release, TSGene contains 716 human (637 protein-coding and 79 non-coding genes), 628 mouse and 567 rat TSGs curated from UniProtKB, the Tumor Associated Gene database and 5795 PubMed abstracts. Additionally, the TSGene provides detailed annotations for each TSG, such as cancer mutations, gene expressions, methylation sites, TF regulations and protein-protein interactions.
Ultrasmall superparamagnetic iron oxide (USPIO)-based liposomes as magnetic resonance imaging probes (2012)

Our results show that the development of sMLs is strictly dependent on the physicochemical characteristics of the nanocores. Once established, sMLs can be further modified to enable noninvasive targeted molecular imaging.
Identification of annexin A13 as a regulator of chemotherapy resistance using random homozygous gene perturbation. (2010)

These findings expand our knowledge of mechanisms that allow tumor cell drug resistance and demonstrate the power of RHGP to identify novel targets and mechanisms.
Abnormal-glow-discharge deposition of tungsten (1987)

α-tungsten films that adhere well to silicon dioxide were deposited using a dc abnormal-glow discharge through WF6, H2, and Ar. Film resistivities on the order of 30 μΩ cm and deposition rates as high as 200 Å/min were obtained without heating the substrate externally. X-ray diffraction, Auger electron spectroscopy, scanning electron microscopy, and transmission electron microscopy measurements indicate that electron scattering at the grain boundaries has limited the conductivity of the plasma-deposited films. Tungsten films having resistivities within a factor of two times that of bulk tungsten were produced with a two-step process utilizing plasma and conventional chemical vapor deposition.
Enzyme Kinetics and Detector Sensitivity Determine Limits of Detection of Amplification-Free CRISPR-Cas12 and CRISPR-Cas13 Diagnostics (2022)

Interest in CRISPR-Cas12 and CRISPR-Cas13 detection continues to increase as these detection schemes enable the specific recognition of nucleic acids. The fundamental sensitivity limits of these schemes (and their applicability in amplification-free assays) are governed by kinetic rates. However, these kinetic rates remain poorly understood, and their reporting has been inconsistent. We quantify kinetic parameters for several enzymes (LbCas12a, AsCas12a, AapCas12b, LwaCas13a, and LbuCas13a) and their corresponding limits of detection (LoD). Collectively, we present quantification of enzyme kinetics for 14 guide RNAs (gRNAs) and nucleic acid targets for a total of 50 sets of kinetic rate parameters and 25 LoDs. We validate the self-consistency of our measurements by comparing trends and limiting behaviors with a Michaelis-Menten <i>trans</i>-cleavage reaction kinetics model. For our assay conditions, activated Cas12 and Cas13 enzymes exhibit <i>trans</i>-cleavage catalytic efficiencies between order 10<sup>5</sup> and 10<sup>6</sup> M<sup>-1</sup> s<sup>-1</sup>. For assays that use fluorescent reporter molecules (ssDNA and ssRNA) for target detection, the kinetic rates at the current assay conditions result in an amplification-free LoD in the picomolar range. The results suggest that successful detection of target requires cleavage (by an activated CRISPR enzyme) of the order of at least 0.1% of the fluorescent reporter molecules. This fraction of reporters cleaved is required to differentiate the signal from the background, and we hypothesize that this required fraction is largely independent of the detection method (e.g., endpoint vs reaction velocity) and detector sensitivity. Our results demonstrate the fundamental nature by which kinetic rates and background signal limit LoDs and thus highlight areas of improvement for the emerging field of CRISPR diagnostics.
The Lincoln large-vocabulary stack-decoder based HMM CSR (1994)

The system described here is a large-vocabulary continuous-speech recognition (CSR) system with results obtained using the Wall Street Journal-based database [15]. The recognizer uses a stack decoder-based search strategy[1, 7, 14] with a left-to-right stochastic language model. This decoder has been shown to function effectively on 20K and 64K-word recognition of continuous speech. It operates left-to-right and can produce final textual output while continuing to accept additional input speech. Thus it need not wait for the end of the sentence and can be structured so that it can accept an unbounded length stream of input speech. The recognizer also features recognition-time adaptation to the user's voice. This system showed improvements of 42% for a 5K vocabulary and 35% for a 20K vocabulary compared to the November 92 evaluation test system.
11-GHz direct modulation bandwidth GaAlAs window laser on semi-insulating substrate operating at room temperature (1984)

We have demonstrated a direct modulation bandwidth of up to 11 GHz in a window GaAlAs buried heterostructure laser fabricated on a semi-insulating substrate, operating at room temperature.
Fabrication of large-area patterned photonic crystals by ink-jet printing (2009)

Large-area patterned photonic crystals (PCs) with multi-stopbands were facilely fabricated by common ink-jet printers using polymer latex suspensions as inks.
급속응고한 Ag-Zn계 전기접점재료에 미치는 Zn함량의 영향 (2008)

Contact materials are used in many electrical devices. Ag-Cd alloy has been widely used in electrical part, because Ag-Cd alloy has a good wear resistance and stable contact resistance. But nowadays Ag-Cd alloy isn`t being used because of environmental challenges. Currently new research is being done on (Ag-SnO2 and Ag-SnO2-In2O3) as an alternative solution to fix any remainly environmental challenges. However In2O3 is more expensive and Ag-Sn alloy has low wear resistance. According to our research data Zn has a similar physical and chemical property. In this work, so we changed and optimized the Zn oxide to over 4 and added Sn oxide ratio 0.5, 1.0, 1.5wt%. Conclusions from the data recorded from the experiment of Ag-ZnO-SnO2 are as follows.
Lycium barbarum Polysaccharide Suppresses Expression of Fibrotic Proteins in Primary Human Corneal Fibroblasts (2020)

(1) Objective: To study the anti-fibrotic effects of <i>Lycium barbarum</i> polysaccharides (LBP) on corneal stromal fibroblasts and assess LBP's effect on cell viability. (2) Methods: Primary human corneal keratocytes of passage 3 to 6 were used for all experiments. Cells are pretreated with LBP solution for 24 h and then transforming growth factor beta 1 (TGFβ1) for 48 h and collected for experiments. Fibrotic protein analysis was performed using immunofluorescence and Western blot. The effect of LBP on cell viability was assessed using the MTS assay. (3) Results: LBP significantly reduced the expression of fibrotic proteins, including α-SMA and extracellular matrix proteins (collagen type I and III). LBP significantly decreased the viability of myofibroblasts but not the fibroblasts. Conclusions: In this study, LBP was effective in the prevention of fibrosis gene expression. Further studies to assess the underlying mechanism and pharmacological properties will facilitate the formation of a topical LBP solution for in vivo studies.
Motion-JPEG2000 standardization and target market (2000)

This paper presents what is going on in Motion-JPEG2000 standardization and its target applications. In this paper, unique features of Motion-JPEG2000 is introduced from many perspectives such as application and market, comparison with other standards, requirements, compression performance compared with Motion JPEG and file format. Since Motion-JPEG2000 guarantees backward compatibility with JPEG-2000 part-1 the market is expected to match.
An efficient technique for accurate modeling and simulation of substrate coupling in deep micron mixed-signal IC's (2010)

Substrate noise in integrated circuits is a major impediment to mixed-signal integration. Accurate simulation is therefore, needed to investigate the generation, propagation, and impact of substrate noise. In this paper, we introduce novel substrate noise estimation and describe a fast and accurate simulator for modeling substrate coupling noise in mixed-signal RF IC design. Using a three-dimensional finite element method for extraction of substrate parasitic elements is developed.
Partial Reversal of Low Molecular Weight Heparin (PK 10169) Anti-Xa Activity by Protamine Sulfate: In vitro and in vivo Study during Cardiac Surgery with Extracorporeal Circulation (1986)

Neutralization of a low molecular weight (LMW) heparin fraction by protamine sulfate was evaluated in vitro and in vivo. Anti-Xa and anti-IIa activities were measured by amidolytic and coagulation methods (activated partial thromboplastin time, APTT). Fifteen patients (4 males and 11 females) underwent surgery with extracorporeal circulation. In vitro, anti-Xa and anti-IIa activities and APTT of unfractionated heparin were neutralized with a protamine/heparin (P/H) gravimetric ratio of 1.6, 1.33 and about 2, respectively. Anti-IIa activity and APTT induced by PK 10169 were completely corrected at a P/H ratio of 1 and 2, respectively, while anti-Xa activity was incompletely neutralized at a ratio of 5. In vivo, in 9 patients who did not receive intravenous protamine sulfate, a good correlation was found between doses of PK 10169 infused, anti-IIa plasma level and blood loss. In 3 patients who were treated prophylactically with protamine, bleeding was normal or only slightly increased. In 3 patients who received protamine because of hemorrhage, mean anti-Xa and anti-IIa were 2.3 and 0.54 U before and 1.32-0.06 U after neutralization. Bleeding was stopped by a second dose of protamine in 1 patient, but blood loss was abnormal in the other patients. However, a correlation between bleeding and anti-Xa or anti-IIa activities was not clearly evident.
Autoclave‐Free Formation of α‐Hemihydrate Gypsum (1991)

Flue gas gypsum may be converted to α‐hemihydrate by suspending the starting material in inorganic salt solutions of high concentration or in diluted sulfuric acid and maintaining the suspension at boiling, or near boiling temperature for a period of time. The crystal morphology of the produced α‐hemihydrate gypsum and, thus, its quality depend significantly on the composition of the liquid phase. Additions of different carbonic acids may improve the quality of the product distinctly. Under optimal working conditions the quality of the formed α‐hemihydrate gypsum is similar to that of a material produced in an autoclave.