gebhart/patrepeval huggingface dataset:
A NOTE ON THE IMPLEMENTATION OF REPLICATION-BASED GARBAGE COLLECTION FOR MULTITHREADED APPLICATIONS AND MULTIPROCESSOR ENVIRONMENTS (1999)

Replication-based incremental garbage collection is one of the more appealing concurrent garbage collection algorithms known today. It allows continuous operation of the application (the mutator) with very short pauses for garbage collection. There is a growing need for such garbage collectors suitable for a multithreaded environments such as the Java Virtual Machine. Furthermore, it is desirable to construct collectors that also work on multiprocessor computers. We begin by pointing out an important, yet subtle point, which arises when implementing the replication-based garbage collector for a multithreaded environment. We first show that a simple and natural implementation of the algorithm may lead to an incorrect behavior of multithreaded applications. We then show that another simple and natural implementation eliminates the problem completely. Thus, the contribution of this part is in stressing this warning to future implementors. Next, we address the effects of the memory coherence model on this algorithm. We show that even when the algorithm is properly implemented with respect to our first observation, a problem might still arise when a multiprocessor system is used. Adopting a naive solution to this problem results in very frequent (and expensive) synchronization. We offer a slight modification to the algorithm which eliminates the problem and requires little synchronization.
HIV integrase inhibitors as therapeutic agents in AIDS (2007)

HIV-1 integrase is a protein of Mr 32 000 encoded at the 3'-end of the pol gene. Integration of HIV DNA into the host cell chromosomal DNA apparently occurs by a carefully defined sequence of DNA tailoring (3'-processing (3'P)) and coupling (integration) reactions. Integration of HIV DNA into human DNA represents the biochemical completion of the invasion of the human cell (e.g., T-cell) by HIV. Unlike major successes seen in the development of clinically approved anti-HIV agents against HIV reverse transcriptase and HIV protease, there are no FDA-approved anti-HIV drugs in clinical use where the mechanism of action is inhibition of HIV integrase. This review summarises some key advances in the area of integrase inhibitors with the major focus being on new generation inhibitors. Special emphasis is placed on diketo acids with aromatic and heteroaromatic moieties, diketo acids with nucleobase scaffolds, bis-diketo acids, functionalised naphthyridines and other isosteres of diketo acids. Data pertaining to integrase inhibition and in vitro anti-HIV activity are discussed. Mention is made of drugs in clinical trials, both past (S-1360, L-870,810 and L-870,812 and present (GS-9137 and MK-0518). Other promising drugs, including those from the authors' laboratory, are referred. Resistant mutants arising from key integrase inhibitors and cross-resistance are indicated.
Ultra-sensitive detection of protein thermal unfolding and refolding using near-zone microwaves (2005)

We use planar slot antennas proximal to proteins in solution to detect changes in conformation. The antennas are attached to fused-quartz or glass sample holders and the cuvette/antenna assembly is placed in the sample holder of an optical spectrophotomer (either UV/VIS or fluorescence polarization), allowing simultaneous dielectric and optical measurements. Return loss is recorded using a vector network analyzer. This system was used to study the equilibrium thermal unfolding and refolding of a small globular protein, as well as the binding of small hormones to a receptor. Good agreement between optical and microwave measurements was obtained for all systems studied. We show that microwave measurements can be made at protein concentrations as low as 0.3 ng/mL (19 pM), several orders of magnitude lower than that required for optical spectroscopy. The results from these experiments demonstrate that resonant slot antennas can be used to detect changes in protein conformation and the presence of microwave radiation does not perturb the system under study.
Characterizing image quality of autostereoscopic displays by using the maximum luminance at each viewing position (2014)

Abstract A metric of the 3D image quality of autostereoscopic displays based on optical measurements is proposed. This metric uses each view's luminance contrast, which is defined as the ratio of maximum luminance at each viewing position to total luminance at that position. Conventional metrics of the autostereoscopic display based on crosstalk, which uses “wanted” and “unwanted” lights. However, in case of the multiple‐views‐type autostereoscopic displays, it is difficult to distinguish exactly which lights are wanted lights and which are unwanted lights. This paper assumes that the wanted light has a maximum luminance at the good stereoscopic viewing position, and the unwanted light also has a maximum luminance at the worst pseudo‐stereoscopic viewing position. By using the maximum luminance that is indexed by view number of the autostereoscopic display, the proposed method enables characterizing stereoscopic viewing conditions without using wanted/unwanted light. A 3D image quality metric called “stereo luminance contrast,” the average of both eyes' contrast, is proposed. The effectiveness of the proposed metric is confirmed by the results of optical measurement analyses of different types of autostereoscopic displays, such as the two‐view, scan‐backlight, multi‐view, and integral.
Design, Synthesis, Pharmacokinetics, and Biodistribution of a Series of Bone-Targeting EP4 Receptor Agonist Prodrugs for Treatment of Osteoporosis and Other Bone Conditions (2021)

A series of bone-targeting EP4 receptor agonist conjugate prodrugs were prepared wherein a potent EP4 receptor agonist was bound to a biologically inactive, bisphosphonate-based bone-targeting moiety. Singly and doubly radiolabeled conjugates were synthesized and were shown to be stable in blood, to be rapidly eliminated from the bloodstream, and to be effectively taken up into bone in vivo after intravenous dosing. From these preliminary studies a preferred conjugate <b>4</b> (also known as <i>C3</i> and Mes-1007) was selected for follow up biodistribution and elimination studies. Doubly radiolabeled conjugate <b>4</b> was found to partition largely to the liver and bones, and both labels were eliminated from liver at the same rate indicating the conjugate was eliminated intact. Quantification of the labels in bones indicated that free EP4 agonist (EP4a)(<b>2a</b>) was released from bone-bound <b>4</b> with a half-time of about 7 days. When dosed orally, radiolabeled <b>4</b> was not absorbed and passed through the gastrointestinal tract essentially unchanged, and only traces of radiolabeled <b>4</b> were found in the liver, blood, or bones. <b>4</b> was found to bind rapidly and completely to powdered bone mineral or to various forms of calcium phosphate, forming a stable matrix suitable for implant and that could made into powders or solid forms and be sterilized without decomposition or release of <b>4</b>. Basic hydrolysis released free EP4 agonist <b>2a</b> quantitatively from the material.
DEVELOPMENT OF POLYMER-BASED DIELECTRIC RESONATOR ANTENNAS FOR MILLIMETER-WAVE APPLICATIONS (2010)

The goal of this paper is to use polymer-based materials (instead of hard ceramics) in fabrication of dielectric resonator antennas at millimeter-wave frequencies. The soft nature of polymers facilitates machining of antennas, while the low permittivity of polymers naturally enhances the bandwidth. More importantly, advantageous properties (e.g., ∞exibility and photosensitivity) of some polymers introduce special capabilities which can not be achieved by ceramics. A photosensitive polymer is utilized in this paper to fabricate polymer-based resonator antennas. As a result, deep X-ray lithography is enabled to produce high quality antenna structures. The proposed dielectric resonator antennas which inherently have very low relative permittivity (usually in a range from 3 to 5) are excited efiectively using a slot-coupled feeding method and analyzed in both the frequency and time domains. Impedance and radiation properties are compared with higher permittivity ceramic antennas. Impedance bandwidths up
<title>Synthesis of two-dimensional wideband ultrasound transducer sparse arrays</title> (1999)

It is widely accepted that a 2D array would be advantageous in medical ultrasound imaging. Such an array would be steerable in both the azimuth and elevation directions. One of the limitations on the practicality of 2D arrays is the electronic channel count. Simple brute force extension of conventional systems to such large systems is not practical. Increasing the number of connections to the transducer elements through the coaxial cable to the probe becomes prohibitive. Increasing the electronics of conventional beamforming systems by a factor of four or eight would be expensive and excessively power consuming. By duplexing, it is possible to double the number of effective channels, however, there is a need for further reduction in the number of channels needed to achieve a practical 2D array.
Improving Parallelism in Hardware Transactional Memory (2018)

Today’s hardware transactional memory (HTM) systems rely on existing coherence protocols, which implement a requester-wins strategy. This, in turn, leads to poor performance when transactions frequently conflict, causing them to resort to a non-speculative fallback path. Often, such a path severely limits parallelism. In this article, we propose very simple architectural changes to the existing requester-wins HTM implementations that enhance conflict resolution between hardware transactions and thus improve their parallelism. Our idea is compatible with existing HTM systems, requires no changes to target applications that employ traditional lock synchronization, and is shown to provide robust performance benefits.
Metabolic Responses of Lactating Dairy Cows to 14-Day Intravenous Infusions of Glucagon (1999)

Twenty cows were assigned at parturition to two groups to study metabolic effects of continuous intravenous infusions of glucagon. Groups were control cows and cows treated with glucagon at 10 mg/d for 14 d starting at d 21 postpartum. Daily blood samples and nine liver biopsies were taken from d 7 to 49 postpartum. Plasma glucagon increased six- to seven-fold during infusions of treated cows. Plasma insulin was increased heterogeneously by glucagon infusions. Plasma glucose increased 11.5 and 9.0 mg/dl during wk 1 and 2 of glucagon infusions. No other plasma metabolites tested (nonesterified fatty acids, beta-hydroxybutyrate, and urea N) were affected by glucagon infusions. Liver glycogen decreased by d 2 of glucagon infusion but was repleted to preinfusion values by d 7 and increased to 169% of the preinfusion baseline values at 3 d after cessation of glucagon. Milk production decreased transiently during glucagon infusions. Both milk production and milk protein percentage decreased during glucagon infusion, which could imply a decreased availability of amino acids for milk protein synthesis. Feed intakes did not increase during glucagon infusions, which was in contrast to the control group. Results indicated that glucagon infusions caused liver glycogenolysis initially and probably enhanced gluconeogenesis but glucagon did not appear to increase lipolysis from adipose tissue in these early lactating dairy cows.
Methods for Displaying Three-Dimensional Images (2006)

The essential components of generating three-dimensional (3-D) images are defined, and various methods of creating each of the components are explained. The components are image acquisition, image multiplexing and processing, and display mechanisms. For image acquisition, transforming, synthesizing based on disparity, voxel and wavefront deformation, and sampling and photographing methods are used. For multiplexing, time, spatial, and spatiotemporal, and for processing, chirping, layering, and pixel cell based multiview image arrangement methods are used. The display mechanisms are classified into projection, contact,and scanning types depending on their means of displaying images. From these methods, 3-D images with real volume, with parallax only and with psychologically induced depth sense can be generated. The display mechanisms have another important mission of creating viewing zones. For this purpose, all 3-D imaging methods employ a special form of optics or mechanisms complying with their image multiplexing schemes. These optics and mechanisms are essential in realizing 3-D imaging systems but at the same time they provide many unfriendly and uncomfortable effects to viewers, and also impose some functional limitations.
Automated Cognitive Health Assessment From Smart Home-Based Behavior Data (2015)

Smart home technologies offer potential benefits for assisting clinicians by automating health monitoring and well-being assessment. In this paper, we examine the actual benefits of smart home-based analysis by monitoring daily behavior in the home and predicting clinical scores of the residents. To accomplish this goal, we propose a clinical assessment using activity behavior (CAAB) approach to model a smart home resident's daily behavior and predict the corresponding clinical scores. CAAB uses statistical features that describe characteristics of a resident's daily activity performance to train machine learning algorithms that predict the clinical scores. We evaluate the performance of CAAB utilizing smart home sensor data collected from 18 smart homes over two years. We obtain a statistically significant correlation ( r=0.72) between CAAB-predicted and clinician-provided cognitive scores and a statistically significant correlation ( r=0.45) between CAAB-predicted and clinician-provided mobility scores. These prediction results suggest that it is feasible to predict clinical scores using smart home sensor data and learning-based data analysis.
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation (2017)

Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed that brain metastases evade phosphatidylinositide 3-kinase (PI3K) inhibition despite drug accumulation in the brain lesions. In comparison to extracranial disease, we observed increased HER3 expression and phosphorylation in brain lesions. HER3 blockade overcame the resistance of <i>HER2</i>-amplified and/or <i>PIK3CA</i>-mutant breast cancer brain metastases to PI3K inhibitors, resulting in marked tumor growth delay and improvement in mouse survival. These data provide a mechanistic basis for therapeutic resistance in the brain microenvironment and identify translatable treatment strategies for <i>HER2</i>-amplified and/or <i>PIK3CA</i>-mutant breast cancer brain metastases.
Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging (2016)

Multiphoton microscopy enables imaging deep into scattering tissues. The efficient generation of non-linear optical effects is related to both the pulse duration (typically on the order of femtoseconds) and the size of the focused spot. Aberrations introduced by refractive index inhomogeneity in the sample distort the wavefront and enlarge the focal spot, which reduces the multiphoton signal. Traditional approaches to adaptive optics wavefront correction are not effective in thick or multi-layered scattering media. In this report, we present sensorless adaptive optics (SAO) using low-coherence interferometric detection of the excitation light for depth-resolved aberration correction of two-photon excited fluorescence (TPEF) in biological tissue. We demonstrate coherence-gated SAO TPEF using a transmissive multi-actuator adaptive lens for in vivo imaging in a mouse retina. This configuration has significant potential for reducing the laser power required for adaptive optics multiphoton imaging, and for facilitating integration with existing systems.
Analytical approaches to photobiological hydrogen production in unicellular green algae (2009)

Several species of unicellular green algae, such as the model green microalga Chlamydomonas reinhardtii, can operate under either aerobic photosynthesis or anaerobic metabolism conditions. A particularly interesting metabolic condition is that of "anaerobic oxygenic photosynthesis", whereby photosynthetically generated oxygen is consumed by the cell's own respiration, causing anaerobiosis in the culture in the light, and induction of the cellular "hydrogen metabolism" process. The latter entails an alternative photosynthetic electron transport pathway, through the oxygen-sensitive FeFe-hydrogenase, leading to the light-dependent generation of molecular hydrogen in the chloroplast. The FeFe-hydrogenase is coupled to the reducing site of photosystem-I via ferredoxin and is employed as an electron-pressure valve, through which electrons are dissipated, thus permitting a sustained electron transport in the thylakoid membrane of photosynthesis. This hydrogen gas generating process in the cells offers testimony to the unique photosynthetic metabolism that can be found in many species of green microalgae. Moreover, it has attracted interest by the biotechnology and bioenergy sectors, as it promises utilization of green microalgae and the process of photosynthesis in renewable energy production. This article provides an overview of the principles of photobiological hydrogen production in microalgae and addresses in detail the process of induction and analysis of the hydrogen metabolism in the cells. Furthermore, methods are discussed by which the interaction of photosynthesis, respiration, cellular metabolism, and H(2) production in Chlamydomonas can be monitored and regulated.
Hovenia dulcis Thunb Extract and Its Ingredient Methyl Vanillate Activate Wnt/β-Catenin Pathway and Increase Bone Mass in Growing or Ovariectomized Mice (2014)

The Wnt/β-catenin pathway is a potential target for development of anabolic agents to treat osteoporosis because of its role in osteoblast differentiation and bone formation. However, there is no clinically available anti-osteoporosis drug that targets this Wnt/β-catenin pathway. In this study, we screened a library of aqueous extracts of 350 plants and identified Hovenia dulcis Thunb (HDT) extract as a Wnt/β-catenin pathway activator. HDT extract induced osteogenic differentiation of calvarial osteoblasts without cytotoxicity. In addition, HDT extract increased femoral bone mass without inducing significant weight changes in normal mice. In addition, thickness and area of femoral cortical bone were also significantly increased by the HDT extract. Methyl vanillate (MV), one of the ingredients in HDT, also activated the Wnt/β-catenin pathway and induced osteoblast differentiation in vitro. MV rescued trabecular or cortical femoral bone loss in the ovariectomized mice without inducing any significant weight changes or abnormality in liver tissue when administrated orally. Thus, natural HDT extract and its ingredient MV are potential anabolic agents for treating osteoporosis.
Sound field compensating apparatus (1994)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Fumio Matsushita, Hiroshi Tsubonuma; Sound field compensating apparatus. J. Acoust. Soc. Am. 1 April 1994; 95 (4): 2300. https://doi.org/10.1121/1.408631 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer (2017)

Resistance to the selective estrogen receptor modulator tamoxifen and to aromatase inhibitors that lower circulating estradiol occurs in up to 50% of patients, generally leading to an endocrine-independent ER+ phenotype. Selective ER downregulators (SERDs) are able to ablate ER and thus, theoretically, to prevent survival of both endocrine-dependent and -independent ER+ tumors. The clinical SERD fulvestrant is hampered by intramuscular administration and undesirable pharmacokinetics. Novel SERDs were designed using the 6-OH-benzothiophene (BT) scaffold common to arzoxifene and raloxifene. Treatment-resistant (TR) ER+ cell lines (MCF-7:5C and MCF-7:TAM1) were used for optimization, followed by validation in the parent endocrine-dependent cell line (MCF-7:WS8), in 2D and 3D cultures, using ERα in-cell westerns, ERE-luciferase, and cell viability assays, with 2 (GDC-0810/ARN-810) used for comparison. Two BT SERDs with superior in vitro activity to 2 were studied for bioavailability and shown to cause regression of a TR, endocrine-independent ER+ xenograft superior to that with 2.
Fast Magnetoresistive Random-Access Memory (1991)

Magnetoresistive binary digital memories of proposed new type expected to feature high speed, nonvolatility, ability to withstand ionizing radiation, high density, and low power. In memory cell, magnetoresistive effect exploited more efficiently by use of ferromagnetic material to store datum and adjacent magnetoresistive material to sense datum for readout. Because relative change in sensed resistance between zero and one states greater, shorter sampling and readout access times achievable.
Correlation of ground friction measurements to aircraft braking friction calculated from flight data recorders (2005)

A two stage investigation approach was carried out constituting a statistical approach to harmonize friction measurement results and a physical model based on aircraft landing and braking dynamics to relate the normalized measurement results to establish meaningful relationship to aircraft braking performance. In this paper the development and analysis of the physical model to determine braking effective friction of passenger aircraft was based on flight data recorder information collected during in-service commercial flights landing on winter contaminated surfaces. Ground friction measurements were taken after each landing to provide data to compare the aircraft friction to those measured by the friction measurement equipment. Results indicate that in addition of the possibility to predict aircraft maximum braking efficiency on winter contaminated runways with ground friction equipment, the harmonization and normalization of such predictions across different measurement techniques is feasible. (a) For the covering entry of this conference, please see ITRD abstract no. E212865.
Ionosphere Effects at the Nanosecond Level Observed in Common-View Time Transfer (1997)

The single-channel “common-view” GPS time-transfer technique is frequently used to minimize the inaccuracy caused by satellite clock errors, including Selective Availability (SA). Even when carefully conducted, these measurements are subject to receiver noise, satellite ephemeris errors, multipath effects, and variable propagation delays. Many of these errors can be reduced if continuous measurements are made on all of the satellites that are in common view. This paper reports results of using this method with multichannel, modular, L1 C/A-code time receivers over a 4,000 km east-west baseline. These results show measurement noise at a level of about 1 ns for averaging times of between 100 s and 2 days without postprocessing. In addition, significant diurnal effects at the level of up to 15 ns peak-to-peak are often observed. These effects appear to be due to differences between the actual ionospheric delays and the predictions of the GPS built-in model. Techniques for mitigating these errors are discussed.