gebhart/patrepeval huggingface dataset:
The Relative Orientation of Gla and EGF Domains in Coagulation Factor X Is Altered by Ca<sup>2+</sup> Binding to the First EGF Domain. A Combined NMR−Small Angle X-ray Scattering Study<sup>,</sup> (1996)

Coagulation factor X is a serine protease containing three noncatalytic domains: an N-terminal gamma-carboxyglutamic acid (Gla)1 domain followed by two epidermal growth factor (EGF)-like domains. The isolated N-terminal EGF domain binds Ca2+ with a Kd of 10(-3) M. When linked to the Gla domain, however, its Ca2+ affinity is increased 10-fold. In this paper, we present the NMR solution structure of the factor X Gla-EGF domain pair with Ca2+ bound to the EGF domain, as well as small angle X-ray scattering (SAXS) data on the Gla-EGF domain pair with and without Ca2+. Our results show that Ca2+ binding to the EGF domain makes the Gla and EGF domains fold toward each other using the Ca2+ site as a hinge. Presumably, a similar mechanism may be responsible for alterations in the relative orientation of protein domains in many other extracellular proteins containing EGF domains with the consensus for Ca2+ binding. The results of the NMR and SAXS measurements reported in this paper confirm our previous result that the Gla domain is folded also in its apo state when linked to the EGF domain [Sunnerhagen, M., et al. (1995) Nat. Struct. Biol. 2, 504-509]. Finally, our study clearly demonstrates the powerful combination of NMR and SAXS in the study of modular proteins, since this enables reliable evaluation of both short-range (NMR) and long-range interactions (SAXS).
Tunable Narrowband Optical Filter in CMOS (2006)

We demonstrate a compact, fully tunable, narrowband (1GHz) 4 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> order pole/zero optical filter that is fabricated in a silicon complementary metal oxide semiconductor foundry.
Signal-Margin-Screening for Multi-Mb MRAM (2006)

As MRAM technology is maturing, the need for developing a strategy to identify and replace marginal bits during read/write operation becomes necessary. The methodology and circuit techniques for read/write signal-margin screening implemented in a 0.18mum 16Mb MRAM design, are described. The methodology leads to increased read/write signal margins resulting in fully functional dice by applying a wafer-level screen test including half select disturb pattern
Semiconductors and Electronic Materials (2000)

Photothermal and Photoacoustic Characterization of Porous Silicon Structures The Peculiarities of Contrast Formation in Photoacoustic Microscopy of Semiconductors and the Role of the Stressed State Optical Detection of Photothermal Phenomena in Operating Electronic Devices - Temperature and Defect Imaging Photothermal Radiometric Study of Implanted Semiconductor Nonradiative Investigation of Impurity and Defect Levels in Si and GaAs by Piezoelectric Photoacoustic Spectroscopy (PPAS) Effect of the Confined Plasma on Thermal Wave Fields in Semiconductor Devices Photothermal Characterization of Semiconductors Nonlinear Photoacoustic and Photothermal Phenomena in Semiconductors Carrier Transport Contribution to Thermoelastic and Electronic Deformation in Semiconductors Photothermal Spectroscopy of Ceramic and Nano-Crystal II-IV Compound Semiconductors, Together with Ternary and Multinary Compounds.
Planning for health at transition (2003)

Linda Ward, Robina Mallett, Pauline Heslop and the late Ken Simons set out to discover what happens to young people with learning disabilities as they move from childhood to adulthood
A systematic review on sperm DNA fragmentation in male factor infertility: Laboratory assessment (2018)

There are pros and cons to all the available SDF assays. TUNEL is a reliable technique with greater accuracy and as an additional diagnostic test in Andrology laboratories along with basic semen analysis can predict fertility outcome, and thus direct the choice of an assisted reproductive technology procedure for infertile couples. Also, the TUNEL assay can be used as a prognostic test and results are beneficial in deciding personalised treatment for infertile men.
Embedded electronics for intelligent structures (1991)

Intelligent structures with integrated control systems consisting of large numbers of distributed sensors, actuators, and processors have been proposed for the precision control of structures. This report examines the feasibility of physically embedding the electronic components of such systems. The hardware implications of functionality distribution are addressed, and it is shown that highly distributed systems can have substantially fewer communications lines and faster control loop speeds than conventional approaches, at the cost of embedding electronic circuit chips. A technique for the embedding procedure is presented which addresses electrical, mechanical, and chemical compatibility issues. Test specimens with functioning integrated circuits successfully embedded within graphite/epoxy composite laminates were subjected to static and cyclic mechanical loads, demonstrating nominal electrical function above normal design load limits. Operation of test specimens in a high temperature/humidity environement allowed the identification of a corrosive failure mode of the leads or lead-chip bonds. The application of a single-chip microcomputer to the control of a structural vibration problem demonstrates the potential for the development of monolithic integrated circuit devices capable of performing distributed processing tasks required for fully integrated intelligent structures.
Ultrafast nonlinear optical loop mirror fordemultiplexing 640 Gbit/s TDM signals (1998)

A 640 Gbit/s TDM signal has been successfully demultiplexed to 10 Gbit/s with a walk-off free, ultrafast, 450 m long nonlinear optical loop mirror (NOLM). The NOLM consists of nine 50 m long sections of dispersion flattened fibre (DFF) with different group delay characteristics. The walk-off between the signal and control pulses for each of the nine fibres was within ±400 fs. By properly connecting them, a total walk-off of < 100 fs has been achieved.
Clustering, resource management, and replication support for scalable network services (2002)

With the increasing demand of providing highly scalable, available and easy-to-manage services, the deployment of large-scale complex server clusters has been rapidly emerging in which service components are usually partitioned, replicated, and aggregated. This dissertation investigates techniques in building a middleware system, called Neptune, that provides clustering support for scalable network services. In particular, Neptune addresses three specific aspects in support of network service clustering: (1) the development of a flexible and scalable clustering architecture with efficient load balancing support for fine-grain services; (2) the design and implementation of an integrated resource management framework that combines the “response time”-based service quality, overall resource utilization efficiency, and service differentiation support; and (3) the design and implementation of a service replication framework focusing on providing flexible replica consistency, performance scalability, and failure recovery support. Neptune has been implemented on Linux and Solaris clusters and a number of applications have been successfully deployed on Neptune platforms, including a large-scale document search engine.
Antitumor effect of new multiple antigen peptide based on <scp>HLA</scp>‐<scp>A</scp>0201‐restricted <scp>CTL</scp> epitopes of human telomerase reverse transcriptase (hTERT) (2012)

The development of peptide vaccines aimed at enhancing immune responses against tumor cells is becoming a promising area of research. Human telomerase reverse transcriptase (hTERT) is an ideal universal target for novel immunotherapies against cancers. The aim of this work was to verify whether the multiple antigen peptides (MAP) based on HLA-A0201-restricted CTL epitopes of hTERT could trigger a better and more sustained CTL response and kill multiple types of hTERT-positive tumor cells in vitro and ex vivo. Dendritic cells (DC) pulsed with MAP based on HLA-A0201-restricted CTL epitopes of hTERT (hTERT-540, hTERT-865 and hTERT-572Y) were used to evaluate immune responses against various tumors and were compared to the immune responses resulting from the use of corresponding linear epitopes and a recombinant adenovirus-hTERT vector. A 4-h standard (51) Cr-release assay and an ELISPOT assay were used for both in vitro and ex vivo analyses. Results demonstrated that targeting hTERT with an adenovector was the most effective way to stimulate a CD8(+) T cell response. When compared with linear hTERT epitopes, MAP could trigger stronger hTERT-specific CTL responses against tumor cells expressing hTERT and HLA-A0201. In contrast, the activated CTL could neither kill the hTERT-negative tumor cells, such as U2OS cells, nor kill HLA-A0201 negative cells, such as HepG2 cells. We also found that these peptide-specific CTL could not kill autologous lymphocytes and DC with low telomerase activity. Our results indicate that MAP from hTERT can be exploited for cancer immunotherapy.
Keynote 6: Time lapse seismic modelling in fractured carbonate reservoirs (2021)

Summary SEAM Life of Field, a collaborative technical project of SEG and the Society of Petroleum Engineers, created a time lapse model that incorporated complex production simulations for a carbonate reservoir. The focus of the project was to create a consistent subsurface model that couples the geologic, reservoir flow, geomechanical, and geophysical models over the life of the carbonate field. One hundred wells were used to model depletion, injection, and water-alternating-gas production, with a one-way coupled geomechanical and flow simulation. Fractures, karst, and faults were included in the models to explore effects on production and the time-lapse seismic responses. Multicomponent seismic acquisition and imaging were conducted at four times during the production, providing a suite of data to investigate imaging and quantitative interpretation technologies.
Detecting and Preventing Forward Head Posture with Wireless Inertial Body Sensor Networks (2011)

Forward Head Posture (FHP) is a common musculoskeletal disorder correlated with neck pain that affects a large percentage of the population. Research has shown that providing feedback for posture auto-correction can help combat FHP and reduce the associated neck pain. However, existing methods for head posture detection are immobile, invasive, and/or inaccurate. This paper presents the use and video-based validation of wireless inertial body sensors for FHP detection. In addition, the effectiveness of bio-feedback is evaluated.
Evolving Catalytic Properties of the MLL Family SET Domain (2015)

Methylation of histone H3 lysine-4 is a hallmark of chromatin associated with active gene expression. The activity of H3K4-specific modification enzymes, in higher eukaryotes the MLL (or KMT2) family, is tightly regulated. The MLL family has six members, each with a specialized function. All contain a catalytic SET domain that associates with a core multiprotein complex for activation. These SET domains segregate into three classes that correlate with the arrangement of targeting domains that populate the rest of the protein. Here we show that, unlike MLL1, the MLL4 SET domain retains significant activity without the core complex. We also present the crystal structure of an inactive MLL4-tagged SET domain construct and describe conformational changes that account for MLL4 intrinsic activity. Finally, our structure explains how the MLL SET domains are able to add multiple methyl groups to the target lysine, despite having the sequence characteristics of a classical monomethylase.
Geographic Names Information System (1984)

The Geographic Names Information System (GNIS) is an automated data system developed by the U.S. Geological Survey (USGS) to standardize and disseminate information on geographic names. GNIS provides primary information for all known places, features, and areas in the United States identified by a proper name. The information in the system can be manipulated to meet varied needs. You can incorporate information from GNIS into your own data base for special applications.
CMU Blizzard 2007: A Hybrid Acoustic Unit Selection System from Statistically Predicted Parameters (2007)

This paper describes CMU’s entry for the Blizzard Challenge 2007. Our eventual system consisted of a hybrid statistical parameter generation system whose output was used to do acoustic unit selection. After testing a number of varied systems, this system proved the best in our internal tests. This paper also explains some of the limitations we see in our techniques. The CMU system is identified as D in the result charts.
Influence of pore geometry on the design of microporous materials for methane storage (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of pore geometry on the design of microporous materials for methane storageRoger F. Cracknell, Peter Gordon, and Keith E. GubbinsCite this: J. Phys. Chem. 1993, 97, 2, 494–499Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/j100104a036https://doi.org/10.1021/j100104a036research-articleACS PublicationsRequest reuse permissionsArticle Views986Altmetric-Citations178LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Discrete-time model of an IPMSM based on variational integrators (2013)

Interior permanent-magnet synchronous motors (IPMSM) are widely used as automobile traction drives for electric and hybrid electric vehicles. Since motor control is commonly implemented on a digital platform, a discrete-time motor model is needed. With respect to the calculation effort the discretization is usually done via a first-order explicit Euler approximation within the rotor frame coordinates. For IPMSM traction drives this approach is leading to a systematic modeling error, since the flux trajectory degenerates from a circle to a polygon at higher speeds. Consequently, this approach leads to a speed-depending discretization error, which can have a significant impact on control performance. Hence, this contribution presents a discrete-time model of an IPMSM based on variational integrators (VI). Starting with a variational principle the Euler-Lagrange equations provide a physical continuous-time motor model. By applying a discrete version of the variational principle we receive a symplectic discrete-time IPMSM model without increasing the calculation effort in comparison to the classical Euler discretization. Simulative as well as experimental investigations confirm the benefit of a VI based discrete-time motor model concerning the transient and stationary system model accuracy.
Spherical Body Protein 4 Is a New Serological Antigen for Global Detection of <i>Babesia bovis</i> Infection in Cattle (2010)

Five Babesia bovis recombinant proteins, including merozoite surface antigen 2c (BbMSA-2c), C-terminal rhoptry-associated protein 1 (BbRAP-1/CT), truncated thrombospondin-related anonymous protein (BbTRAP-T), spherical body protein 1 (BbSBP-1), and spherical body protein 4 (BbSBP-4), were evaluated as diagnostic antigens to detect the infection in cattle. The recombinant proteins were highly antigenic when tested with experimentally B. bovis-infected bovine serum in Western blot analysis. Furthermore, five antisera that had been raised against each of the recombinant proteins reacted specifically with the corresponding authentic protein, as determined in Western blot analysis. Next, enzyme-linked immunosorbent assays (ELISAs) using these recombinant proteins were evaluated for diagnostic use, and the sensitivity and specificity of each protein were demonstrated with a series of serum samples from experimentally B. bovis-infected cattle. Furthermore, a total of 669 field serum samples collected from cattle in regions of B. bovis endemicity in seven countries were tested with the ELISAs, and the results were compared to those of an indirect fluorescent antibody test (IFAT), as a reference. Among five recombinant antigens, recombinant BbSBP-4 (rBbSBP-4) had the highest concordance rate (85.3%) and kappa value (0.705), indicating its reliability in the detection of specific antibodies to B. bovis in cattle, even in different geographical regions. Overall, we have successfully developed an ELISA based on rBbSBP-4 as a new serological antigen for a practical and sensitive test which will be applicable for epidemiologic survey and control programs in the future.
Retrieval method of enormous POI in vehicle navigation system (2009)

In vehicle navigation system, POI(points of interest) retrieval is important. Since the restriction of the embedded system, the retrieval should deal with enormous POI data in limited external memory and internal memory, when the retrieval speed should fit for the vehicle navigation. The rapid retrieval method is designed for solving the problem. The method is based on Chinese Pinyin. It includes the storage method of search table with digital search tree and character compression. The method for retrieving in the compressed data is also designed. By the design, the size of the file for the POI retrieval is reduced, so the demand of external and internal memory is lower, when the retrieval is fast enough for the vehicle navigation.
Hybrid Approach Combining Machine Learning and a Rule-Based Expert System for Text Categorization (2011)

This paper discusses a novel hybrid approach for text categorization that combines a machine learning algorithm, which provides a base model trained with a labeled corpus, with a rule-based expert system, which is used to improve the results provided by the previous classifier, by filtering false positives and dealing with false negatives. The main advantage is that the system can be easily fine-tuned by adding specific rules for those noisy or conflicting categories that have not been successfully trained. We also describe an implementation based on k-Nearest Neighbor and a simple rule language to express lists of positive, negative and relevant (multiword) terms appearing in the input text. The system is evaluated in several scenarios, including the popular Reuters-21578 news corpus for comparison to other approaches, and categorization using IPTC metadata, EUROVOC thesaurus and others. Results show that this approach achieves a precision that is comparable to top ranked methods, with the added value that it does not require a demanding human expert workload to train
Miniaturized wireless ECG-monitor for real-time detection of epileptic seizures (2010)

Recent advances in miniaturization of ultra-low power components allow for more intelligent wearable health monitors. Such systems may be used in a wide range of application areas. Here, the development and evaluation of a wireless wearable electrocardiogram (ECG) monitor to detect epileptic seizures from changes in the cardiac rhythm is described. The ECG is measured using an ultra-low-power circuit for bio-potential acquisition. The ECG data is continuously analyzed by embedded algorithms: a robust beat-detection algorithm combined with a real-time heart beat-based epileptic seizure detector. Each detected seizure candidate triggers its transmission to a receiving radio-station. At the same time, the detected events and the raw ECG data are stored on an embedded memory card from which they can be wirelessly downloaded for off-line analysis. The performance of the system in terms of power-consumption, robustness of the radio-link and comfort of use is reported. In its current implementation, the proposed ECG-monitor prototype has a size of 52x36x15mm3, and an autonomy of one day. Wireless, miniaturized and comfortable, this prototype opens new perspectives for continuous and ambulatory health monitoring.
Structured semi-blind interference rejection in dispersive multichannel systems (2002)

The impact of interference is one of the most capacity limiting factors in cellular networks today. In order to host more users in existing systems and maximize the capacity of future networks, the use of interference suppression techniques are instrumental. We propose a structured semi-blind parameter estimation procedure to support rejection of unknown cochannel interference (CCI) in systems facing multipath channels with non-negligible delay spread. Employing spatio-temporal processing, the proposed scheme exploits the temporal correlation present in the output signal from an antenna array and the training data of a desired user in order to find parameter estimates that fit the range space of a structured CCI model to the signal subspace of the interfering signals. Simulation results illustrating the behavior of a spatio-temporal receiver using the proposed scheme with respect to both signal-to-noise and signal-to-interference ratios (SNRs and SIRs) are presented. In addition, results highlighting the impact of the training sequence length as well as the impact of the channel model order of the CCI users are also included.
Size of IgG-Opsonized Particles Determines Macrophage Response during Internalization (1998)

It is generally assumed that particles > 1 micron elicit a phagocytic response. To determine whether this is the case, we examined the uptake and transport of IgG-opsonized polystyrene beads of defined size, ranging from 0.2 to 3 microns, by mouse bone marrow-derived macrophages. The kinetics of opsonized bead internalization were comparable for each of the different beads examined. We used rhodamine phalloidin to examine particle-induced assembly of F-actin phagocytic cups by fluorescence microscopy. Phagocytic cup formation was size dependent in a nonlinear fashion. Less than 30% of 0.2- to 0.75-micron particles and greater than 80% of 2- and 3-micron particles were associated with F-actin. Cells treated with 0.25 micron cytochalasin D showed decreased phagocytic cup formation and a linear decrease in bead uptake as a function of particle surface area. In contrast, potassium depletion, which preferentially inhibits clathrin-mediated endocytosis, was more effective at inhibiting the uptake of smaller beads. Thus, with increasing particle size, IgG-opsonized particle uptake became less clathrin dependent and more actin dependent. The kinetics of ligand delivery to lysosomes was measured using an immunoprecipitation assay based on the intermixing of internalized anti-dinitrophenol (DNP) IgG with DNP-derivitized beta-glucuronidase (DNP-beta-glu) incorporated into lysosomes. Soluble mannosylated anti-DNP IgG was delivered to lysosomes after an 8-min lag period. The kinetics of anti-DNP IgG-opsonized beads showed a size-dependent response, where beads sized 0.2, 0.5, and 0.75 micron showed a lag period prior to delivery to lysosomes. In contrast, beads 1.0 micron or larger showed no lag in delivery to lysosomes. Since beads that had no lag in delivery to lysosomes also showed high levels of phagocytic cup formation, this suggests that phagocytic cups may be important in the rapid delivery of internalized particles to lysosomes.