gebhart/patrepeval huggingface dataset:
Treatment of Patients With Acquired Immunodeficiency Syndrome and Associated Manifestations (1987)

Treatment of AIDS is multidisciplinary and often involves input from a number of medical subspecialties. Treatment of opportunistic infections and malignancies in AIDS is largely palliative in that these treatments do not reverse the underlying immunodeficiency. Investigational approaches to the treatment of this syndrome with immunomodulators and antiviral agents are currently being investigated with the hope that these agents, either alone or in combination, will be active against this devastating disease.
Rapid reversal of stress induced loss of synapses in CA3 of rat hippocampus following water maze training (2003)

The impact was examined of exposing rats to two life experiences of a very different nature (stress and learning) on synaptic structures in hippocampal area CA3. Rats were subjected to either (i) chronic restraint stress for 21 days, and/or (ii) spatial training in a Morris water maze. At the behavioural level, restraint stress induced an impairment of acquisition of the spatial response. Moreover, restraint stress and water maze training had contrasting impacts on CA3 synaptic morphometry. Chronic stress induced a loss of simple asymmetric synapses [those with an unperforated postsynaptic density (PSD)], whilst water maze learning reversed this effect, promoting a rapid recovery of stress-induced synaptic loss within 2-3 days following stress. In addition, in unstressed animals a correlation was found between learning efficiency and the density of synapses with an unperforated PSD: the better the performance in the water maze, the lower the synaptic density. Water maze training increased the number of perforated synapses (those with a segmented PSD) in CA3, both in stressed and, more notably, in unstressed rats. The distinct effects of stress and learning on CA3 synapses reported here provide a neuroanatomical basis for the reported divergent effects of these experiences on hippocampal synaptic activity, i.e. stress as a suppressor and learning as a promoter of synaptic plasticity.
U-path: An undirected path-based measure of semantic similarity. (2014)

In this paper, we present the results of a method using undirected paths to determine the degree of semantic similarity between two concepts in a dense taxonomy with multiple inheritance. The overall objective of this work was to explore methods that take advantage of dense multi-hierarchical taxonomies that are more graph-like than tree-like by incorporating the proximity of concepts with respect to each other within the entire is-a hierarchy. Our hypothesis is that the proximity of the concepts regardless of how they are connected is an indicator to the degree of their similarity. We evaluate our method using the Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT), and four reference standards that have been manually tagged by human annotators. The overall results of our experiments show, in SNOMED CT, the location of the concepts with respect to each other does indicate the degree to which they are similar.
Solution Properties of Poly(4-vinylpyridine) in Aqueous Solutions of Sulfuric Acid (1992)

Abstract The conformation of poly(4-vinylpyridine) (P4VP) in aqueous solutions of sulfuric acid was studied by light scattering and viscosity measurements at 25 °C. Comparing the experimental intramolecular particle scattering factor (P(θ)) and Debye’s theory, it was confirmed that in the Θ-state where the apparent second virial coefficient is zero, the conformation of P4VP is characterized as a Gaussian chain. The intrinsic viscosities of P4VP in aqueous solutions of sulfuric acid of various concentrations were analyzed according to the theoretical equation of Tanaka. The value of the characteristic ratio (C∞) increased with increasing H2SO4 concentration.
SharPer: Sharding Permissioned Blockchains Over Network Clusters (2021)

Scalability is one of the main roadblocks to business adoption of blockchain systems. Despite recent intensive research on using sharding techniques to enhance the scalability of blockchain systems, existing solutions do not efficiently address cross-shard transactions. In this paper, we introduce SharPer, a scalable permissioned blockchain system. In SharPer, nodes are clustered and each data shard is replicated on the nodes of a cluster. SharPer supports networks consisting of either crash-only or Byzantine nodes. In SharPer, the blockchain ledger is formed as a directed acyclic graph and each cluster maintains only a view of the ledger. SharPer incorporates decentralized flattened protocols to establish cross-shard consensus. The decentralized nature of the cross-shard consensus in SharPer enables parallel processing of transactions with nonoverlapping clusters. Furthermore, SharPer provides deterministic safety guarantees. The experimental results reveal the efficiency of SharPer in terms of performance and scalability especially in workloads with a low percentage of cross-shard transactions.
Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus (1994)

We have used linker scanning and site-directed mutagenesis in an attempt to distinguish among the known functions of the duck hepatitis B virus large envelope protein, p36. We found that linker-encoded amino acid substitutions in at least one region of the pre-S envelope protein p36 produced defects in both the production of enveloped virus and the regulation of covalently closed circular DNA (cccDNA) synthesis. Most linker substitutions, typically in the 5' two-thirds of the pre-S region of the p36 gene did not affect either cccDNA regulation or enveloped virus production but did destroy the infection competence of the enveloped particles produced. Single amino acid substitutions of residues 128 and 131 demonstrated a similar correlation between defects in the ability of p36 to support enveloped virus production and to control cccDNA levels. We concluded from these studies that virus production and cccDNA regulation probably require a common activity of p36.
Cervicogenic headache. The differentiation from common migraine. An overview. (1991)

Common migraine and cervicogenic headache have many traits in common, so many that they may be mixed up. Both are unilateral headaches with a female preponderance. However, as for a number of variables, they differ. This first and foremost has to do with factors concerning the neck. In cervicogenic headache, the following symptoms and signs are present: a reduced range of motion in the neck; mechanical precipitation of attack, either by neck movements or by external pressure over the greater occipital nerve of the C2 root; ipsilateral shoulder/arm pain; unilaterality without side-shift. Similar findings are usually not made in common migraine. Typical migraine symptoms, such as nausea, vomiting, photophobia, and phonophobia also occur in cervicogenic headache, but less frequently and to a lesser degree. Operative procedures directed to occipital/nuchal structures may afford decisive differentiation between the two disorders. In our estimation, cervicogenic headache and common migraine are two distinct disorders, with their own clinical patterns, pathogenesis, treatment - and, in all probability, also prognosis.
Managing requirements uncertainty in engine control systems development (2011)

In the development of complex systems the requirements for the system will almost always remain uncertain late into the software development. In gas turbine engine control systems at Rolls-Royce, typically 50% of requirements will change between Critical Design Review and Entry into Service. Ignoring or not planning for requirements uncertainty will cause scrap and rework that will manifest later in the project. This paper evaluates the impact of not managing these uncertainties and describes how Rolls-Royce uses Requirements Uncertainty Analysis to reduce this impact. The paper summarises the findings from an extensive Six Sigma study into requirements uncertainty and provides an overview of the technique now used to identify and monitor uncertainty through a project life. The return on investment of this technique has been between 100:1 and 500:1.
Real-time Imaging of Lymphogenic Metastasis in Orthotopic Human Breast Cancer (2006)

Metastatic spread to regional lymph nodes is one of the earliest events of tumor cell dissemination and presents a most significant prognostic factor for predicting survival of cancer patients. Real-time in vivo imaging of the spread of tumor cells through the lymphatic system can enhance our understanding of the metastatic process. Herein, we describe the use of in vivo fluorescence microscopy imaging to monitor the progression of lymph node metastasis as well as the course of spontaneous metastasis through the lymphatic system of orthotopic MDA-MB-231 human breast cancer tumors in severe combined immunodeficient mice. High-resolution noninvasive visualization of metastasizing cancer cells in the inguinal lymph nodes was achieved using cells expressing high levels of red fluorescent protein. Sequential imaging of these lymph nodes revealed the initial invasion of the tumor cells through the lymphatic system into the subcapsular sinuses followed by intrusion into the parenchyma of the nodes. FITC-dextran injected i.d. in the tumor area enabled simultaneous tracking of lymphatic vessels, labeled in green, and disseminated red cancer cells within these vessels. Fast snapshots of spontaneously metastasizing cells in the lymphatic vessels monitored the movement of a few tumor cells and the development of clumps clustered at lymphatic vessel junctions. Quantification of high interstitial fluid pressure (IFP) in the tumors and fast drainage rates of the FITC-dextran into the peritumoral lymphatic vessels suggested an IFP-induced intravasation into the lymphatic system. This work presents unprecedented live fluorescence images that may help to clarify the steps occurring in the course of spontaneous lymphogenic metastasis.
Sequential extraction procedure for the speciation of particulate trace metals (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequential extraction procedure for the speciation of particulate trace metalsA. Tessier, P. G. C. Campbell, and M. BissonCite this: Anal. Chem. 1979, 51, 7, 844–851Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/ac50043a017https://doi.org/10.1021/ac50043a017research-articleACS PublicationsRequest reuse permissionsArticle Views24132Altmetric-Citations8471LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Implementing RFID technology in a novel triage system during a simulated mass casualty situation (2008)

The purpose of this study is to determine the applicability of Radio Frequency Identification (RFID) technology and commercial cellular networks to provide an online triage system for handling mass casualty situations. This was tested by a using a pilot system for a simulated mass casualty situation during a military field exercise. The system proved to be usable. Compared to the currently used system, it also dramatically improves the general view of mass casualty situations and enhances medical emergency readiness in a military medical setting. The system can also be adapted without any difficulties by the civilian sector for the management of mass casualty disasters.
Bulbocavernosus Reflex to Somatic and Visceral Nerve Stimulation in Normal Subjects and in Diabetics With Erectile Impotence (1987)

Bulbocavernosus reflex to stimulation of the vesicourethral junction and glans penis was recorded in 14 normal controls and 24 diabetic men complaining of erectile impotence. In all normal subjects the bulbocavernosus reflex to stimulation of these sites could be obtained, and mean latencies were 59.2 +/- 8.0 msec. and 33.3 +/- 3.7 msec., respectively (p less than 0.00001). A total of 66 per cent of the diabetics (16 patients) exhibited abnormal (delayed or absent) bulbocavernosus reflex to stimulation of the vesicourethral junction, while only 12.5 per cent (3 patients) had delayed response to glans penis stimulation. The latter tended to remain within normal limits, although the mean latency was significantly different from that of normal subjects (p less than 0.05). Abnormalities of the bulbocavernosus reflex to stimulation of the vesicourethral junction correlated strongly with the presence of peripheral and autonomic neuropathy, diabetes and organogenic impotence. Our results indicate that this is an informative test for the evaluation of visceral afferents arising from the bladder neck and, hence, in the differential diagnosis of organogenic versus psychogenic erectile impotence.
Rapid selection of mesenchymal stem and progenitor cells in primary prostate stromal cultures (2016)

Primary prostate stromal cultures are highly enriched in cells with an MSC or stromal progenitor phenotype. The use of primary cultures such as these to study CAFs raises interesting implications when considering their overlapping properties. The lack of adipogenesis in stromal cultures derived from normal prostates suggests they have a lineage-restricted progenitor phenotype. The retention of adipogenic differentiation in cultures from a subset of prostate cancer patients suggests the active recruitment of less committed progenitors or MSCs from the bone marrow as a function of disease progression. This recruitment can potentially be exploited for prognostic purposes or a cell-based platform for the systemic delivery of cytotoxic agents to sites of prostate cancer.
The progeny of rabbit articular chondrocytes synthesize collagen types I and III and type I trimer, but not type II. Verifications by cyanogen bromide peptide analysis (1977)

The radioactive collagens synthesized by the fourth subculture progeny of rabbit articular chondrocytes were extracted and purified after limited pepsin digestion by neutral and acid salt precipitation. In order to identify the different types of collagen present, denatured collagen chains were fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis on 5% gels, electrophoretically eluted, and cleaved with cyanogen bromide, and the resultant peptides were fractionated by a new sodium dodecyl sulfate electrophoresis system (tris(hydroxymethyl)aminomethane-borate buffer, 15% gels). Comparison of these separate peptide profiles with those from alpha1(I) and alpha1(III) collagen chains permitted the unambiguous identification of these chains in the radioactive collagen synthesized by chondrocytes. Although cartilage slices predominantly synthesized alpha1(II) chains, only alpha1(I) chains were made by cells in fourth subculture. A large fraction of these alpha1(I) chains could not be accounted for by the presence of type I collagen. While in a native, triple-helical conformation, some of these extra alpha1(I) chains were completely separated from type I collagen by their solubility at pH 8.0 in 2.6 M NaCl and therefore identified as [alpha1(I)]3, type I trimer. In addition to type I collagen and type I trimer, these chondrocyte progeny also synthesized type III collagen and two new collagen chains, X and Y. Each collagen type was further characterized by carboxymethylcellulose chromatography and its distribution between the medium and the cell layer. These findings support the idea that cultured chondrocytes assume a collagen phenotype similar to that of their undifferentiated mesenchymal cell precursors.
Future CO <sub>2</sub> Emissions and Climate Change from Existing Energy Infrastructure (2010)

Slowing climate change requires overcoming inertia in political, technological, and geophysical systems. Of these, only geophysical warming commitment has been quantified. We estimated the commitment to future emissions and warming represented by existing carbon dioxide-emitting devices. We calculated cumulative future emissions of 496 (282 to 701 in lower- and upper-bounding scenarios) gigatonnes of CO2 from combustion of fossil fuels by existing infrastructure between 2010 and 2060, forcing mean warming of 1.3 degrees C (1.1 degrees to 1.4 degrees C) above the pre-industrial era and atmospheric concentrations of CO2 less than 430 parts per million. Because these conditions would likely avoid many key impacts of climate change, we conclude that sources of the most threatening emissions have yet to be built. However, CO2-emitting infrastructure will expand unless extraordinary efforts are undertaken to develop alternatives.
Migrated intrauterine device (IUD) - late uterine perforation during lactation (2020)

Uterine perforation post IUD insertion is rare and may occur either as immediate uterine perforation - caused by a traumatic insertion, or, late uterine perforation - caused by the progressive erosion through the myometrium. Current professional recommendations give no eligibility restriction for postpartum IUD insertion, regardless of whether or not the patient is breast-feeding.
We present the case of a 34-year-old patient, who had an IUD (T-Cu 380A, 32 mm) inserted at 12 weeks postpartum, on an anteverted uterus, without any incidents during the insertion. Approximately four months after the insertion, the patient was admitted for mild, intermittent pelvic pain, light bloody vaginal discharge, and digestive complaints. During the gynaecological consult, no withdrawal strings were seen in the cervix. The transvaginal ultrasound confirmed the absence of the device from the uterine cavity. It could not be seen in the myometrium, in the peritoneal cavity, or in the bladder.
The abdominal X-ray (Figure 1) identified the parauterine location of the device. The laparoscopic removal of the migrated intrauterine device was performed. The device was found in the posterior uterine wall, partially penetrating it, in an uncommon position if we are to consider the literature. It had a transversal intra-myometrium arm - a D2 type perforation, apparently – but the longitudinal axis and the withdrawal strings were in the peritoneal cavity (Figure 2), being loculated by the epiploon and intestinal loops (Figure 3), with lax adherences, which enabled the device extraction rather easily, without any contiguity lesions.
To Catch a Ratter: Monitoring the Behavior of Amateur DarkComet RAT Operators in the Wild (2017)

Remote Access Trojans (RATs) give remote attackers interactive control over a compromised machine. Unlike large-scale malware such as botnets, a RAT is controlled individually by a human operator interacting with the compromised machine remotely. The versatility of RATs makes them attractive to actors of all levels of sophistication: they've been used for espionage, information theft, voyeurism and extortion. Despite their increasing use, there are still major gaps in our understanding of RATs and their operators, including motives, intentions, procedures, and weak points where defenses might be most effective. In this work we study the use of DarkComet, a popular commercial RAT. We collected 19,109 samples of DarkComet malware found in the wild, and in the course of two, several-week-long experiments, ran as many samples as possible in our honeypot environment. By monitoring a sample's behavior in our system, we are able to reconstruct the sequence of operator actions, giving us a unique view into operator behavior. We report on the results of 2,747 interactive sessions captured in the course of the experiment. During these sessions operators frequently attempted to interact with victims via remote desktop, to capture video, audio, and keystrokes, and to exfiltrate files and credentials. To our knowledge, we are the first large-scale systematic study of RAT use.
When Good Brands Do Bad (2004)

This article reports results from a longitudinal field experiment examining the evolution of consumer-brand relationships. Development patterns differed, whereby relationships with sincere brands deepened over time in line with friendship templates, and relationships with exciting brands evinced a trajectory characteristic of short-lived flings. These patterns held only when the relationship proceeded without a transgression. Relationships with sincere brands suffered in the wake of transgressions, whereas relationships with exciting brands surprisingly showed signs of reinvigoration after such transgressions. Inferences concerning the brand's partner quality mediated the results. Findings suggest a dynamic construal of brand personality, greater attention to interrupt events, and consideration of the relationship contracts formed at the hands of different brands.
Measuring Dark Adaptation in the Elderly: A Predictor of Who May Develop Macular Degeneration? (2014)

and patient fatigue). The authors show that, after adjustment for age, 22% of subjects had impaired, baseline dark-adaptation kinetics despite absence of AMD, and that these abnormalities correlated with elevated C-reactive protein, a serological marker of inflammation, and with high blood pressure, and exhibited a J-shaped correlation with alcohol intake. This study is of special interest to AMD research in that it provides potential evidence for a functional biomarker that could precede the onset of detectable AMD. It will now be interesting to see if the abnormal dark-adaptation kinetics found at baseline will translate in greater risk of developing AMD and if they will correlate with any nutritional factor and/or genetic marker of AMD. If so, studies of dark adaptometry in the elderly may prove invaluable in predicting who is at greatest risk of AMD, leading to earlier and better treatment, and providing an important outcome measure for trials of AMD.
In‐Memory Hamming Weight Calculation in a 1T1R Memristive Array (2020)

Abstract In‐memory computing enabled by advanced nonvolatile memory technologies, such as memristors and memristive devices, emerges as a promising approach to accelerate certain data‐intensive algorithms, and thus outperforms the von Neumann computing in terms of processing latency and energy efficiency. In this work, an efficient method to calculate the Hamming weight (HW) of a binary string in a one‐transistor‐one‐resistor (1T1R) memristive array is proposed, which can be beneficial for various computation tasks. Specifically, the target string is converted to a voltage vector and multiplies with an “all‐1” string pre‐stored in the resistance of the row, which equals to a binary matrix multiplication or AND logic operation. The in situ stored HW calculation result is then read out through a current accumulation operation. As a proof‐of‐concept demonstration, 4 bit and 8 bit HW calculation is successfully implemented in experiment and simulation, respectively. In addition, the influence of the resistance variation on the calculation correctness is discussed. This work broadens the application range of using emerging nonvolatile memories for classical information processing in hardware level with high efficiency.