gebhart/patrepeval huggingface dataset:
NKp30-based chimeric antigen receptors promote T-cell effector functions and anti-tumor efficacy (53.11) (2012)

Abstract NKp30 is a natural cytotoxicity receptor (NCR) that is expressed on natural killer (NK) cells and recognizes B7-H6, which is expressed on several types of tumors but few normal cells. To target effector T cells against B7-H6-positive tumors, we have developed several chimeric antigen receptors (CAR) based on NKp30, which contain the CD28, Dap10, CD27, and/or CD3ζ signaling domains with the transmembrane domains from CD3ζ, CD28, or CD8α. The NKp30 CAR expressing T cells produced IFN-γ and killed B7-H6 ligand-expressing tumor cells. This response was dependent upon ligand expression on target cells but not on MHC expression. The inclusion of other signaling domains enhanced chimeric NKp30 CAR-mediated activity compared to CD3ζ alone. Adoptive transfer of T cells expressing a chimeric NKp30 receptor containing a CD28 signaling domain inhibited the growth of a B7-H6-expressing murine lymphoma (RMA/B7-H6) in vivo. Moreover, mice that remained tumor-free were resistant to a subsequent challenge with the wild-type RMA tumor cells, suggesting the generation of immunity against other tumor antigens. Overall, this study demonstrates the therapeutic potential of adoptive immunotherapy with NKp30 CAR-expressing T cells against B7-H6+ tumor cells.
Injection locking of coupled-stripe diode laser arrays (1985)

The control of the far-field beam pattern and the spectrum of 10-element laser diode array by injection locking to a single-mode master laser are described. With less than 3 mW of injected power an array output of 105 mW at a single frequency with a 0.5° wide far-field lobe is obtained. Similar results are observed when the entire array is illuminated by the master laser beam, or when only one of the stripes is illuminated. The narrow lobe contains 60–70% of the total power and is centered at an angle of about 4° relative to the normal of the array facet.
Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections (2009)

β-lactamase enzyme-activated photosensitizer (β-LEAP). We aim to exploit drug resistance mechanisms to selectively release photosensitizers (PSs) for a specific photodynamic antimicrobial effect and reduced host tissue damage. Consequently, the fluorescence emission intensity of the PSs increases and allows for the detection of enzyme activity. In this work we sought to evaluate β-LEAP for use as a sensitive molecular probe. We have reported the enzyme specific antibacterial action of β-LEAP. Here we report the use of β-LEAP for the rapid functional definition of a β-lactamase.
Squares: Supporting Interactive Performance Analysis for Multiclass Classifiers (2016)

Performance analysis is critical in applied machine learning because it influences the models practitioners produce. Current performance analysis tools suffer from issues including obscuring important characteristics of model behavior and dissociating performance from data. In this work, we present Squares, a performance visualization for multiclass classification problems. Squares supports estimating common performance metrics while displaying instance-level distribution information necessary for helping practitioners prioritize efforts and access data. Our controlled study shows that practitioners can assess performance significantly faster and more accurately with Squares than a confusion matrix, a common performance analysis tool in machine learning.
A thermotolerant and high acetic acid-producing bacterium Acetobacter sp. I14-2 (1999)

A thermotolerant bacterium with high production of acetic acid was isolated from spoiled banana in Taiwan. The isolate, I14–2, was considered to be an Acetobacter sp. according to phenotypic and chemotaxonomic characteristics. Optimal cultural conditions for Acetobacter sp. I14–2 to produce acetic acid were studied under cultivation in a medium containing 2 mg l−1 acetic acid and 5% ethanol at 30 °C. Acetic acid productivity by Acetobacter sp. I14–2 was almost two and three times the amount produced by Acet. aceti IFO3283 and Acetobacter sp. CCRC 12326, respectively. The isolate retained 22% residual acetic acid‐producing activity after 3 d incubation in a medium containing 8% ethanol, and produced acetic acid in a medium containing 10 g l−1 acetic acid. This bacterium is thermotolerant and retained 97% and 68% of acetic acid‐producing activity after 3 d incubation at 35 °C and 37 °C, respectively, compared with that when incubated at 30 °C.
Optimisation of resolution and color reproduction for color LCD by control of brightness and contrast levels (2003)

Usually LCDs (liquid crystal displays) have brightness and contrast controls. Because the optimal image quality depends on the choice of these controls, it becomes necessary to know how different combinations of the brightness and contrast levels influence the image quality. The image quality of a color display depends on both resolution and color reproduction. The resolution is determined by the spot size and SNR (signal-to-noise ratio) of the displayed image. Better resolution requires smaller spot size and higher SNR. The color reproduction is determined by the constant-channel chromaticity, the reproducible color gamut, and the luminance level of the white point. The faithful color reproduction needs the satisfaction of chromaticity constancy, large color gamut, and high luminance. Because the brightness and contrast controls affect the luminance and chromaticity of the background screen and signal screen, the resolution and color reproduction depend on their settings. Using a color LCD, we studied the optimized combination of brightness and contrast control to display the image with high resolution and faithful color reproduction.
Electrically driven photonic crystal nanocavity devices (2012)

We demonstrate electrically driven photonic crystal cavity lasers and LEDs with record low control energies. Our lateral injection platform opens the door to new opportunities in active control of photonic crystal devices.
[The molecular genetics of rheumatoid arthritis disease gene]. (2002)

Rheumatoid arthritis(RA) is a chronic polyarthritis of unknown etiology affecting approximately 1% of the population worldwide. Previous studies have shown that the ratio of the risk for siblings of patients with the disease versus the prevalence of that disease in the general population (lambda s) is much greater in RA, suggesting that genetic factors may be involved in familial clustering. Using microsatellite marker analysis and sib-pair linkage study, we have identified three chromosome regions D1S214/253, D8S556 and DXS1232/984 as candidate loci for RA disease genes. In this article, we review the molecular genetic findings on the RA disease genes located respectively at each of the above chromosome regions. We show that the death receptor 3(DR3) gene, a Fas family member, containing nucleotide polymorphism is the candidate disease gene located at D1S214/253. We also identify the mutant forms of angiopoietin-1(Ang-1) and Dbl proto-oncogenes respectively as the candidate genes located at D8S556 and DXS1232/984. We surmise that these mutations are responsible for the impairment of apoptosis induction, angiogenesis and leukocyte function in the patients, which may predispose to autoimmunity.
Combined TRU-Sr extraction/recovery process (1993)

The combined TRU-SR extraction/recovery process is a new solvent extraction process that is designed to extract uranium, neptunium, plutonium, americium, strontium, and technetium from dissolved sludge obtained from Hanford waste storage tanks. The process utilizes a solvent formulation consisting of 0.2 M octyl(phenyl)-N,N-diisobutyl-carbainoylmethylphosphine oxide (CMPO), 0.2 M 4,4 inches (5 inches)-di-t-butylcyclohexanol8-crown-6 (DtBuCH18C6),-and 1.2 M diamyl amylphosphonate (DA[AP]) in an isoparaffinic hydrocarbon diluent. Distribution ratios of Am, Sr, and {Tc} (the least extractable constituents) from synthetic waste containing 3 M HN0{sub 3} are 40, 8, and 3, respectively. Selective backextraction of Np, Pu, Am, and Sr from U and {Tc} is achieved using a new carboxylic acid reagent. Uranium and technetium backextraction is achieved with 0.25 M Na{sub 2}CO{sub 3}. A flowsheet has been designed for testing the combined process in high speed centrifugal contactors. Synthetic dissolved sludge waste spiked with U, TRUs, {sup 85}Sr and {sup 99m}{Tc} will be used as the feed. A sufficient number of stages are utilized to remove > 99.99% of the TRUs and Sr and > 90% of the {Tc}.
Computational reconfigurable imaging spectrometer (2017)

We demonstrate a novel hyperspectral imaging spectrometer based on computational imaging that enables sensitive measurements from smaller, noisier, and less-expensive components (e.g. uncooled microbolometers), making it useful for applications such as small space and air platforms with strict size, weight, and power requirements. The computational reconfigurable imaging spectrometer (CRISP) system exploits platform motion and a spectrally coded focal-plane mask to temporally modulate the optical spectrum, enabling simultaneous measurement of multiple spectral bins. Demodulation of this coded pattern returns an optical spectrum in each pixel.
Postural Transitions during Activities of Daily Living Could Identify Frailty Status: Application of Wearable Technology to Identify Frailty during Unsupervised Condition (2017)

This study demonstrated that daily number of specific postural transitions such as walk-to-stand and quick sitting could be used for monitoring frailty status by unsupervised monitoring of daily physical activity. Further study is warranted to explore whether tracking the daily number of specific postural transitions is also sensitive to track change in the status of frailty over time.
Magnetically Activated Micromixers for Separation Membranes (2011)

Presented here is a radically novel approach to reduce concentration polarization and, potentially, also fouling by colloids present in aqueous feeds: magnetically responsive micromixing membranes. Hydrophilic polymer chains, poly(2-hydroxyethyl methacrylate) (PHEMA), were grafted via controlled surface-initiated atom transfer radical polymerization (SI-ATRP) on the surface of polyamide composite nanofiltration (NF) membranes and then end-capped with superparamagnetic iron oxide magnetite (Fe(3)O(4)) nanoparticles. The results of all functionalization steps, that is, bromide ATRP initiator immobilization, SI-ATRP, conversion of PHEMA end groups from bromide to amine, and carboxyl-functional Fe(3)O(4) nanoparticle immobilization via peptide coupling, have been confirmed by X-ray photoelectron spectroscopy (XPS) and field emission scanning electron microscopy (FESEM). These nanoparticles experience a magnetic force as well as a torque under an oscillating external magnetic field. It has been shown, using particle image velocimetry (PIV), that the resulting movement of the polymer brushes at certain magnetic field frequencies induces mixing directly above the membrane surface. Furthermore, it was demonstrated that with such membranes the NF performance could significantly be improved (increase of flux and salt rejection) by an oscillating magnetic field, which can be explained by a reduced concentration polarization in the boundary layer. However, the proof-of-concept presented here for the active alteration of macroscopic flow via surface-anchored micromixers based on polymer-nanoparticle conjugates has much broader implications.
Automatic architectural synthesis of VLIW and EPIC processors (1999)

This paper describes a mechanism for automatic design and synthesis of very long instruction word (VLIW), and its generalization, explicitly parallel instruction computing (EPIC) processor architectures starting from an abstract specification of their desired functionality. The process of architecture design makes concrete decisions regarding the number and types of functional units, number of read/write ports on register files, the data-path interconnect, the instruction format, its decoding hardware, and the instruction unit data-path. The processor design is then automatically synthesized into a detailed RTL-level structural model in VHDL along with an estimate of its area. The system also generates the corresponding detailed machine description and instruction format description that can be used to retarget a compiler and an assembler respectively. All this is part of an overall design system, called Program-In-Chip-Out (PICO), which has the ability to perform automatic exploration of the architectural design space while customizing the architecture to a given application and making intelligent, quantitative, cost-performance tradeoffs.
Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Novel high chromium containing braze filler metals for heat exchanger applications (2007)

A new family of boron-free, high chromium containing braze filler metal compositions were developed (Amdry 105, Amdry 108, Amdry 805). Filler metal properties including metallurgical phases, melting range, flow, corrosion resistance and high temperature oxidation resistance are reported. Additionally, the technical and economical advantages of using these new filler metals in fabricating flat plate type of heat exchangers and metallic catalytic converters is discussed. (orig.)
Quasilinear spin-torque nano-oscillator via enhanced negative feedback of power fluctuations (2013)

We report on an approach to improving the performance of spin-torque nano-oscillators (STNOs) that utilizes power-dependent negative feedback to achieve significantly enhanced dynamic damping. In combination with a sufficiently slow variation of frequency with power, this can result in a quasilinear STNO, with weak nonlinear coupling of power and phase fluctuations over a range of bias currents and fields. An implementation of this approach that utilizes nonuniform spin torque applied to the oscillating magnetic free layer of a nanoscale spin-valve device demonstrates that highly coherent room-temperature STNOs can be achieved while retaining sufficient tunability.
A display calibration technique based on invariant human colour mechanisms (2005)

When human observers are asked to adjust a coloured light such that it appears neither red nor green, or such that it appears neither yellow nor blue, most colour-normal observers have no difficulty in making these adjustments. Furthermore, these colour appearance judgements are not significantly influenced by language or age [Saunders and van Brakel 1997] and individual differences in colour sensitivity are not reflected in the unique hues settings [Webster et al. 2000]. The human colour system seems to be able to calibrate itself so that there is a remarkable agreement across observers in relation to these unique hue judgements. Here we show how we can use the invariance of these unique hue judgements to develop a colour calibration technique for display devices which eliminates the need for an external calibration standard or a measurement device.
Ultra-thin compound semiconductor on insulator (XOI) for MOSFETs and TFETs (2011)

Due to their high electron mobility, III–V semiconductors are promising channel materials for future devices [1]. InAs is one such promising material; however, due to the small bandgap (E <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</inf> ∼0.36 eV) bulk devices are not feasible. In addition, heteroepitaxial growth of thin layers on Si is challenging due to the inherent lattice mismatch. Here, we present a platform developed for integration of single-crystalline ultra-thin compound semiconductor layers on insulator (XOI)[2], resembling the conventional SOI substrates.
A high throughput, noncontact system for screening silicon wafers predisposed to breakage during solar cell production (2011)

We describe a non-contact, on-line system for screening wafers that are likely to break during solar cell/module fabrication. The wafers are transported on a conveyor belt under a light source, which illuminates the wafers with a specific light distribution. Each wafer undergoes a dynamic thermal stress whose magnitude mimics the highest stress the wafer will experience during cell/module fabrication. As a result of the stress, the weak wafers break, leaving only the wafers that are strong enough to survive the production processes. We will describe the mechanism of wafer breakage, introduce the wafer system, and discuss the results of the time-temperature (t-T) profile of wafers with and without microcracks.
Impact of boron penetration at the p/sup +/-poly/gate-oxide interface on the device reliability of deep submicron CMOS logic technology (2002)

Impact of boron penetration at the p/sup +/-poly/gate-oxide interface is investigated. It is shown that the onset of boron penetration at this interface can not be detected by conventional threshold or flatband voltage shifts of p-channel devices, but it results in significantly lower Q/sub BD/ and Vt instability. Constant current stress in inversion has been found to be most sensitive technique to monitor the onset of boron at the p/sup +/-poly/gate-oxide interface.
Mediation by G Proteins of Signals That Cause Collapse of Growth Cones (1993)

During development, motion of nerve growth cones ceases on contact with particular targets. The signaling mechanism is unknown. In culture, growth cone collapse can be caused by solubilized embryonic brain membranes, central nervous system myelin, a 35-kilodalton protein isolated from myelin, and mastoparan. Collapse induced by each of these is blocked by pertussis toxin. Thus, collapse of growth cones is mediated by G protein-coupled receptors, which may be activated by proteins associated with the cell surface as well as by soluble ligands.
Preliminary Evaluations of a Self-Contained Anthropomorphic Transfemoral Prosthesis (2009)

This paper presents a self-contained powered knee and ankle prosthesis, intended to enhance the mobility of transfemoral amputees. A finite-state based impedance control approach, previously developed by the authors, is used for the control of the prosthesis during walking and standing. Experiments on an amputee subject for level treadmill and overground walking are described. Knee and ankle joint angle, torque, and power data taken during walking experiments at various speeds demonstrate the ability of the prosthesis to provide a functional gait that is representative of normal gait biomechanics. Measurements from the battery during level overground walking indicate that the self-contained device can provide more than 4500 strides, or 9 km, of walking at a speed of 5.1 km/h between battery charges.
A semi-synthetic glycoconjugate antigen prepared by chemical glycosilation of pertussis toxin by a meningococcal group C oligosaccharide hapten. (1985)

The preparation of a hybrid molecule obtained by chemical glycosilation of pertussis toxin (PT) is reported, with the purpose of obtaining a semi-synthetic glycoprotein antigen with bivalent antigenicity. The chemical glycosilation was performed using an oligosaccharide hapten derived from the purified capsular polysaccharide of Neisseria meningitidis group C. The semi-synthetic molecule was investigated by chemico-physical and immunochemical analysis. The oligosaccharide haptens appeared exposed on the surface of the carrier protein PT, since the glycoprotein inhibited the immunoprecipitate between a specific polyclonal antiserum and the native bacterial capsular polysaccharide. By contrast, the main antigenic regions recognized in the native protein PT by specific polyclonal antibodies appeared lost after the coupling procedure involving PT as the carrier protein.
FV10: an efficient single-layer approach to HDR coding, with backward compatibility options (2016)

High Dynamic Range and Wide Color Gamut (HDR/WCG) video is now at the forefront of modern broadcast and other video delivery systems. The efficient transmission and display of such video over diverse networks and systems is an important problem. This paper presents a novel, state of the art approach in HDR/WCG video coding (called FV10) which uses a new, fully automatic video data adaptive regrading process, which converts HDR to Standard Dynamic Range (SDR). Our method differs from one developed recently in standards committees (the Joint Collaborative Team on Video Coding, or JCT-VC, of ITU|ISO/IEC), based on the HEVC Main10 Profile as the core codec, which is an HDR10 compliant system (“anchor”). FV10 also works entirely within the framework of HEVC Main10 Profile, but makes greater use of existing SEI messages. Reconstructed video using our methods show a subjective visual quality superior to the output of an example HDR10 anchor. Moreover, a usable backwards compatible SDR video is obtained as a byproduct in the processing chain, allowing service efficiencies. Representative objective results for the system include: results for RGB-PSNR, DE100, MD100, tOSNR-XYZ were -46.0%, -21.6%, -29.6%, 16.2% respectively.
A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy (2021)

Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive effect of this peptide with isoniazid and ethambutol and confirmed these results with ethambutol in a murine TB-model. In vivo, the peptide remained stable in circulation and preserved lung structure better than ethambutol alone. Antibiotic resistance studies did not induce mutants with reduced susceptibility to the peptide. We further observed that this peptide was effective against nontuberculous mycobacteria (NTM), such as M. avium and M. abscessus, and several Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In conclusion, the presented data supports a role for this CHDP in the treatment of drug resistant organisms.