gebhart/patrepeval huggingface dataset:
Noninvasive laser coagulation of the canine vas deferens, in vivo (2010)

Development of a noninvasive vasectomy technique may eliminate male fear of complications (incision, bleeding, infection, and scrotal pain) and result in a more popular procedure. This study builds upon previously reported ex vivo tissue studies by exploring acute and short-term chronic in vivo canine studies. Isolation of the canine vas was achieved using a conventional vas ring clamp method. No perforation of the scrotal skin was necessary to occlude the vas. Laser radiation with a wavelength of 1075 nm, average power of 11.2 W, 500-ms pulse duration, 0.5 Hz pulse rate, and 3-mm-diameter spot was synchronized with cryogen spray cooling of the scrotal skin surface in a total of 8 dogs (n = 16 vasa) for a treatment time of 60 s. Burst pressure measurements were conducted at Days 0 and 21 (n = 8 vasa each day) to quantify the strength of vas closure. The vas was successfully thermally occluded in 15/16 (94%) procedures with 14/15 (93%) vas recording burst pressures above ejaculation pressure. One vas was not present, and another vas recorded a bursting pressure below ejaculation pressure. The coagulated vas bursting pressure averaged 283 ± 34 mm Hg at Day 0 and 260 ± 77 mm Hg at Day 21, significantly higher than reported vas ejaculation pressures of 136 ± 29 mm Hg. Minor scrotal skin burns were observed during the recovery period. Noninvasive thermal occlusion of the vas is feasible in an in vivo canine model. Elimination of minor skin burns and longer term chronic in vivo canine studies are needed to confirm azospermia after vas occlusion without recanalization.
Controlling murine and rat chronic pain through A <sub>3</sub> adenosine receptor activation (2012)

Clinical management of chronic neuropathic pain is limited by marginal effectiveness and unacceptable side effects of current drugs. We demonstrate A(3) adenosine receptor (A(3)AR) agonism as a new target-based therapeutic strategy. The development of mechanoallodynia in a well-characterized mouse model of neuropathic pain following chronic constriction injury of the sciatic nerve was rapidly and dose-dependently reversed by the A(3)AR agonists: IB-MECA, its 2-chlorinated analog (Cl-IB-MECA), and the structurally distinct MRS1898. These effects were naloxone insensitive and thus are not opioid receptor mediated. IB-MECA was ≥1.6-fold more efficacious than morphine and >5-fold more potent. In addition, IB-MECA was equally efficacious as gabapentin (Neurontin) or amitriptyline, but respectively >350- and >75-fold more potent. Besides its potent standalone ability to reverse established mechanoallodynia, IB-MECA significantly increased the antiallodynic effects of all 3 analgesics. Moreover, neuropathic pain development in rats caused by widely used chemotherapeutics in the taxane (paclitaxel), platinum-complex (oxaliplatin), and proteasome-inhibitor (bortezomib) classes was blocked by IB-MECA without antagonizing their antitumor effect. A(3)AR agonist effects were blocked with A(3)AR antagonist MRS1523, but not with A(1)AR (DPCPX) or A(2A)AR (SCH-442416) antagonists. Our findings provide the scientific rationale and pharmacological basis for therapeutic development of A(3)AR agonists for chronic pain.
Video Stabilization by Feature-Block Motion Estimation (2008)

This paper presents a real-time video stabilization method for adjusting unstable frames captured by a vibrating camera. The basic idea is to calculate the vibration degree for compensating the vibration area by block motion detection and analyzing vibration type. A feature block is selected to obtain the vibration vector for checking if the frame is vibrant, and then the missing area is compensated and the overlapping area is adjusted. Experimental results show that the proposed algorithm can effectively reduce the frame vibration in real-time for the general vibration situations of moderate degree and compensate more than 21 pixels.
PlaneRCNN: 3D Plane Detection and Reconstruction from a Single Image (2018)

This paper proposes a deep neural architecture, PlaneRCNN, that detects and reconstructs piecewise planar surfaces from a single RGB image. PlaneRCNN employs a variant of Mask R-CNN to detect planes with their plane parameters and segmentation masks. PlaneRCNN then jointly refines all the segmentation masks with a novel loss enforcing the consistency with a nearby view during training. The paper also presents a new benchmark with more fine-grained plane segmentations in the ground-truth, in which, PlaneRCNN outperforms existing state-of-the-art methods with significant margins in the plane detection, segmentation, and reconstruction metrics. PlaneRCNN makes an important step towards robust plane extraction, which would have an immediate impact on a wide range of applications including Robotics, Augmented Reality, and Virtual Reality.
<title>Novel x-ray mask inspection tool based on transmission x-ray conversion microscope</title> (1996)

We present the design and preliminary experimental results on a novel x-ray mask inspection tool based on a transmission x-ray secondary electron conversion microscope (TXsecM). The x-ray beam transmitted through the mask impinges onto a high quantum yield photoemissive cathode located at the plane where the wafer will be placed in the stepper. The cathode converts photons into low energy secondary electrons with narrow bandwidth, and the electrons are then imaged by a specially designed low voltage electrostatic lens column with 1200X magnification. Therefore, the micrographs thus obtained represent an accurate map of the x-ray radiation on the resist in an actual production exposure. TXsecM is an ideal tool for x-ray mask inspection as well as image formation analysis in real time. The design goal is to achieve 20nm spatial resolution.
Reconfigurable antennas and configuration selection methods for MIMO ad hoc networks (2011)

In this paper, we quantify the performance enhancements that can be provided by reconfigurable antennas in an ad hoc network where all nodes employ multiple input multiple output communication techniques. We present two types of reconfigurable antennas: a reconfigurable printed dipole array (RPDA), and a reconfigurable circular patch antenna (RCPA). The RPDA and RCPA have a different number of configurations as well as different degrees of pattern diversity between possible configurations. To effectively use these antennas in a network, we introduce and quantify the performance of centralized and decentralized antenna configuration selection schemes for reconfiguration at one or both link ends. We use the sum capacity of the network as a metric to quantify the performance of these antennas in measured and simulated network channels.
Revision of the oral glucose tolerance test: a pilot study (1990)

Nausea and vomiting have been recurrent problems with the oral glucose tolerance tests (OGTT) used to diagnose diabetes. We believe the nausea is associated with delayed gastric emptying caused by the high osmolarity of the glucose solution. In our pilot study, both the "standard" 100-g glucose OGTT and our new modified (lower osmolar) glucose solution were evaluated. Considerably delayed gastric emptying (along with severe nausea) was consistently noted with the standard OGTT. No nausea and a much more rapid gastric emptying time were recorded when the modified glucose solution was administered. We were able to diagnose diabetes (by using Wilkerson's point system) when our modified OGTT was administered to type 2 diabetics. We plan to develop a more physiological, more reproducible, and better tolerated OGTT to diagnose diabetes more accurately in the general population.
Prospects for a Prostaglandin Bronchodilator (1980)

I. Introduction The reports in 1968 that PGE1 and PGE2 could relax or block the constriction of isolated human bronchial tissue by mechanisms apparently not involving the adrenergic or cholinergic receptors (3,4; also see 5,6,7), and the subsequent observations that upon aerosol administration bronchodilation could be induced in asthmatic subjects (8,9; also see 10-13) spotlighted the prostaglandins as a potentially important new approach to bronchodilator therapy. However, it also was apparent that the natural prostaglandins would not find clinical application, since they induce cough and irritation of the upper respiratory tract. (Other problems associated with their use: delayed onset of action, short duration of effect, headaches, and also the inherent chemical instability of the 11-hydroxyprostaglandins.) Nevertheless, because their mechanism of action was different from that of the known bronchodilators (4), the prostaglandins did represent an important and exciting lead to further advances in bronchodilator therapy. Obviously this was a situation
Estimating multi-layer scattering in faces using direct-indirect separation (2008)

No abstract available.
Topoisomerase I (Top1): a major target of FL118 for its antitumor efficacy or mainly involved in its side effects of hematopoietic toxicity? (2017)

FL118 is a novel camptothecin (CPT) analogue that possesses exceptional antitumor efficacy in human tumor animal models. To date, two CPT analogues, irinotecan and topotecan, have been approved by the FDA for cancer treatment. FL118 exhibits superior antitumor activity over irinotecan and topotecan, and effectively overcomes the irinotecan- or topotecan-resistant human tumors in animal models. Accordingly, FL118 selectively inhibits the expression of multiple cancer-associated proteins (survivin, Mcl-1, XIAP, cIAP2, MdmX). However, FL118 has hematopoietic toxicity similar to irinotecan and topotecan, suggesting that FL118's hematopoietic toxicity may share a mechanism similar to irinotecan and topotecan. It is known that CPTs including irinotecan, SN-38 (active metabolite of irinotecan) and topotecan are topoisomerase I (Top1) inhibitors. However, the evidence from our studies failed to reveal that FL118 is a better Top1 inhibitor than SN-38. It was documented that Top1 expression level is positively associated with CPTs' sensitivity. Low Top1 expression links to CPTs' resistance. In contrast to these findings, we found that human colorectal tumor sensitivity to FL118 is irrelevant to the expression level of Top1 protein. FL118 can show high antitumor efficacy in Top1-negative tumors, while Top1 highly positive tumors can exhibit FL118 resistance. This suggests that the presence of Top1 target is not critical for FL118 antitumor activity. In other words, targeting Top1 by FL118 may not play a major role for its antitumor efficacy. However, studies indicate that FL118 can bind to, and inhibit Top1 activity. This raises the possibility that inhibition of Top1 by FL118 may predominantly be involved in hematopoietic toxicity, but not in FL118 antitumor activity. In this article, we will summarize existing observations and provide our up-to-date research results to support our opinion on this important topic.
A thermal microprobe fabricated with wafer-stage processing (1998)

A thermal microprobe has been designed and built for high resolution temperature sensing. The thermal sensor is a thin-film thermocouple junction at the tip of an atomic force microprobe (AFM) silicon probe needle. Only wafer-stage processing steps are used for the fabrication. For high resolution temperature sensing it is essential that the junction be confined to a short distance at the AFM tip. This confinement is achieved by a controlled photoresist coating process. Experiment prototypes have been made with an Au/Pd junction confined to within 0.5 μm of the tip, with the two metals separated elsewhere by a thin insulating oxide layer. Processing begins with double-polished, n-type, 4 in. diameter, 300-μm-thick silicon wafers. Atomically sharp probe tips are formed by a combination of dry and wet chemical etching, and oxidation sharpening. The metal layers are sputtering deposited and the cantilevers are released by a combination of KOH and dry etching. A resistively heated calibration device was made for temperature calibration of the thermal microprobe over the temperature range 25–110 °C. Over this range the thermal outputs of two microprobes are 4.5 and 5.6 μV/K and is linear. Thermal and topographical images are also obtained from a heated tungsten thin film fuse.
Emulsion Stabilization of Minor Slides in Exploratory Trenches (1982)

Research Article| November 01, 1982 Emulsion Stabilization of Minor Slides in Exploratory Trenches PATRICK E. SMITH; PATRICK E. SMITH Staff Geologist Naval Weapons Center, Code 383, China Lake, CA 93555 Search for other works by this author on: GSW Google Scholar GLENN R. ROQUEMORE; GLENN R. ROQUEMORE Research Geologist Naval Weapons Center, Code 383, China Lake, CA 93555 Search for other works by this author on: GSW Google Scholar ERIC W. BANKS ERIC W. BANKS Staff Geologist Naval Weapons Center, Code 383, China Lake, CA 93555 Search for other works by this author on: GSW Google Scholar Environmental and Engineering Geoscience (1982) xix (4): 339–345. https://doi.org/10.2113/gseegeosci.xix.4.339 Article history first online: 02 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation PATRICK E. SMITH, GLENN R. ROQUEMORE, ERIC W. BANKS; Emulsion Stabilization of Minor Slides in Exploratory Trenches. Environmental and Engineering Geoscience 1982;; xix (4): 339–345. doi: https://doi.org/10.2113/gseegeosci.xix.4.339 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentBy SocietyEnvironmental and Engineering Geoscience Search Advanced Search Abstract Minor slides in an exploratory trench, excavated in unconsolidated sand and gravel across the Garlock fault, were stabilized with Airflex A-400 nontoxic grade emulsion (glue). Trench wall disintegration was a result of minor slides associated with fault planes. Sliding was initiated by (1) bulldozer vibrations, (2) normal gravitational forces, and (3) the wind. A 800 1 tank pump and a 12 1 hand pump were used to apply a water-diluted 5 percent emulsion. The resulting emulsion-sand crust varied in thickness as a function of the application procedures. This crust supplied no structural support (not intended to replace shoring); however, it provided a surface cohesion that effectively stopped all sliding and allowed normal engineering logging to proceed. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not currently have access to this article.
Production of metal oxide thin films by pulsed arc molecular beam deposition (2000)

Deposition for the first time of titanium oxide, cerium oxide, and tin oxide thin films by reactive pulsed arc molecular beam deposition is reported. To produce these thin films, oxygen gas was pulsed between a pair of electrodes situated within a vacuum chamber. A 20 μf storage capacitor was discharged between the electrode pair during the gas pulse. A substrate was placed inline with the oxygen pulse, on which an oxide coating of the electrode material was then coated. The films were analyzed by both scanning electron microscopy and electron spectroscopy for chemical analysis. There was a noted strong dependence of the film surface quality on the melting temperature of the starting electrode material.
A Novel Percutaneous Barrier Device that Permits Safe Subcutaneous Access (1999)

Successful subcutaneous access is important for optimal management of internal artificial organs and treatment of many diseases. However, skin downgrowth and tissue infection are still significant problems in the use of devices that require long-term subcutaneous access. The authors developed a new percutaneous device that provides a unique biologic boundary with surrounding connective tissue while minimizing the risk of complications. This new percutaneous device is made of a circumferential, strong, thin, and flexible mesh collar with millimeter size holes for connecting the structure. It has two distinct functional portions: a connecting zone and a sealing line. The most important features of the structure are: 1) Connective tissue grows through the millimeter size pores of the connecting zone to form a strong bond between the device and healthy tissue. 2) The millimeter size pores of the connecting zone allow capillaries to grow through its entire surface, ensuring sufficient blood supply. 3) The tissue of the connecting zone and the device surface form a biosealed junction (sealing line). This sealing line is protected by the connecting zone and is free from external forces acting on local skin. 4) The device is generally functional immediately after surgical implantation. The subcutaneous perimeter of the functional dome contains extruded rigid rings of millimeter size holes permitting growth of subcutaneous tissue through the device. This functions as the minor connecting structure of the device. Four of five implanted rabbits have remained healthy 8 months postimplantation without antibiotic administration. The fifth rabbit died 4 months postimplantation for reasons unrelated to the device. Gross or histopathologic inspection revealed no signs of tissue injury or inflammation. Growth of healthy connective tissue was clearly observed. These results indicate this percutaneous device can provide a strong, stable, and effective connection to internal organs without bioboundary damage, skin downgrowth, or tissue infection.
Derivation of Human Parthenogenetic Stem Cell Lines (2011)

Pluripotent stem cells (PSCs) derived from parthenogenetically activated human oocytes demonstrate the typical characteristics displayed by human embryonic stem cells (hESCs) including infinite division and in vitro and in vivo differentiation into cells of all germ lineages. Different activation techniques allow the creation of either human leukocyte antigen (HLA) heterozygous human parthenogenetic stem cell (hpSC) lines, which are HLA-matched/histocompatible with the oocyte donor, or HLA-homozygous hpSC lines, which may be histocompatible to significant segments of the human population. This immune-matching advantage, combined with the advantage of derivation from nonviable human embryos that originate from unfertilized parthenogenetically activated oocytes, makes hpSCs a promising source of PSCs for cell-based transplantation therapy. This chapter describes two approaches for the parthenogenetic activation of human oocytes, their cultivation to the blastocyst stage, and the subsequent derivation of PSC lines.
Immunization with a Single Dose of a Microencapsulated <i>Brucella melitensis</i> Mutant Enhances Protection against Wild-Type Challenge (2008)

The development of safe and efficacious immunization systems to prevent brucellosis is needed to overcome the disadvantages of the currently licensed vaccine strains that restrict their use in humans. Alginate microspheres coated with a protein of the parasite Fasciola hepatica (vitelline protein B [VpB]) and containing live Brucella melitensis attenuated mutant vjbR::Tn5 (BMEII1116) were evaluated for vaccine efficacy and immunogenicity in mice. A single immunization dose in BALB/c mice with the encapsulated vjbR mutant improved protection against wild-type B. melitensis 16M challenge compared to the nonencapsulated vaccine strain (P < 0.05). The encapsulated mutant was also shown to induce a sustained elevation of Immunoglobulin G levels. Cytokine secretion from spleen cells of mice vaccinated with the encapsulated vjbR::Tn5 revealed elevated secretion of gamma interferon and interleukin-12, but no interleukin-4, suggesting an induction of a T helper 1 response reflecting the enhanced immunity associated with microencapsulation. Together, these results suggest that microencapsulation of live attenuated organisms offers the ability to increase the efficacy of vaccine candidates.
Synthesis and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines of Thieno[2,3-d]pyrimidine Derivatives Containing Isoxazole Moiety (2017)

Under the guidance of our previous achievements, and in order to extend this small molecular library. In current work, other 21 novel structures of thieno[2,3-d]pyrimidines containing isoxazole-moiety (1a-1u) were firstly synthesized and the cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method. The results showed that most target compounds exhibited good to excellent cytotoxicity to A549, HCT116 and MCF-7 cell lines, especially 6-Methyl-4-{[3-(4-chlorophenyl)-isoxazol-5-yl-]-methoxy-}-thieno[2,3-d]-pyrimidine (1e) exhibited a broad-spectrum and the most potent cytotoxicity to A549, HCT116 and MCF-7 cell lines (IC50s: 2.79, 6.69 and 4.21&times;10-3 &mu;M, respectively) as compared with the reference drug gefitinib (IC50s: 17.90, 21.55 and 20.68 &mu;M, respectively). 1e can be seen as the best drug candidates for development of anticancer drugs.
Fracture Risk Predictions Based on Statistical Shape and Density Modeling of the Proximal Femur (2014)

Increased risk of skeletal fractures due to bone mass loss is a major public health problem resulting in significant morbidity and mortality, particularly in the case of hip fractures. Current clinical methods based on two-dimensional measures of bone mineral density (areal BMD or aBMD) are often unable to identify individuals at risk of fracture. We investigated predictions of fracture risk based on statistical shape and density modeling (SSDM) methods using a case-cohort sample of individuals from the Osteoporotic Fractures in Men (MrOS) study. Baseline quantitative computed tomography (QCT) data of the right femur were obtained for 513 individuals, including 45 who fractured a hip during follow-up (mean 6.9 year observation, validated by physician review). QCT data were processed for 450 individuals (including 40 fracture cases) to develop individual models describing three-dimensional bone geometry and density distribution. Comparison of mean fracture and non-case models indicated complex structural differences that appear to be responsible for resistance to hip fracture. Logistic regressions were used to model the relation of baseline hip BMD and SSDM weighting factors to the occurrence of hip fracture. Area under the receiver operating characteristic (ROC) curve (AUC) for a prediction model based on weighting factors and adjusted by age was significantly greater than AUC for a prediction model based on aBMD and age (0.94 versus 0.83, respectively). The SSDM-based prediction model adjusted by age correctly identified 55% of the fracture cases (and 94.7% of the non-cases), whereas the clinical standard aBMD correctly identified 10% of the fracture cases (and 91.3% of the non-cases). SSDM identifies subtle changes in combinations of structural bone traits (eg, geometric and BMD distribution traits) that appear to indicate fracture risk. Investigation of important structural differences in the proximal femur between fracture and no-fracture cases may lead to improved prediction of those at risk for future hip fracture.
Improving Plating by Use of Intense Acoustic Beams (2003)

An improved method of selective plating of metals and possibly other materials involves the use of directed high-intensity acoustic beams. The beams, typically in the ultrasonic frequency range, can be generated by fixed-focus transducers (see figure) or by phased arrays of transducers excited, variously, by continuous waves, tone bursts, or single pulses. The nonlinear effects produced by these beams are used to alter plating processes in ways that are advantageous.