gebhart/patrepeval huggingface dataset:
Soft actuator for robotic applications based on dielectric elastomer: dynamic analysis and applications (2003)

In this paper a new soft actuator based on dielectric elastomer is proposed. The actuator, called an antagonistically-driven linear actuator (ANTLA), has the muscle-like characteristics capable of performing the motions such as forward/backward/controllable compliance. In this paper, its dynamic analysis is performed with experimental verifications, and applications for robotic actuating devices are introduced.
Fast photon counting in negative corona discharges in the Trichel regime (1988)

Using a fast pulse counting system with a time resolution of 0.7 ns, the intensity has been measured of the light originating from a negative corona discharge in the Trichel regime in air, resolved in time, in position in the gap and in wavelength. The dominant spectral lines originate from the second positive system of N2. Both the current and the emission from the plasma carrying the current show a fast increase on a nanosecond timescale and a successive slower decrease. Repetition frequencies are in the MHz range. The maximum of the light pulse intensity corresponds with the maximum of the Trichel pulse. The continuum emission measured originates from the attachment processes during the maximum in the current pulse. The electron density estimated from the continuum measurements is 1018 m-3 at maximum for air at a pressure of 100 kPa. From observed Cul line emission the sputter rate for positive ions impinging on the cathode tip has been determined to be 4*10-5 atoms ion-1.
The DaNeX Study of Embryonic Mesencephalic, Dopaminergic Tissue Grafted to a Minipig Model of Parkinson's Disease: Preliminary Findings of Effect of MPTP Poisoning on Striatal Dopaminergic Markers (2000)

A multicenter study is under way to investigate the efficacy of allografting of embryonic mesencephalic neurons in a pig model of Parkinson's disease. We have first established that a stable parkinsonian syndrome can be established by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication of adult male Göttingen minipigs. We are now using positron emission tomography (PET) methods for testing the physiological responses to MPTP intoxication and the time course of the response to several treatment strategies. We now report preliminary results obtained in 11 pigs employed in the initial phase of the study; the completed study shall ultimately include 30 pigs. Animals were randomly assigned to one of five groups: 1) Control, 2) MPTP intoxication, 3) MPTP intoxication followed by allograft, 4) MPTP intoxication followed by allograft with immunosuppression, and 5) MPTP intoxication followed by allograft with immunosuppression and co-grafting of immortalized HiB5 cells, which had been manipulated to secrete glia cell line-derived neurotrophic factor (GDNF) (approximately 2 ng GDNF/h/10(5) cells). MPTP was administered (1 mg/kg/day, SC) for 7-10 days until the pigs had developed mild parkinsonian symptoms of muscle rigidity, hypokinesia, and impaired coordination, especially of the hind limbs. Approximately 2 weeks after the last MPTP dose, animals received a T1-weighted magnetic resonance imaging (MRI) scan, and a series of dynamic PET recordings. After the first series of PET scans, four grafts of porcine embryonic mesencephalic tissue (E28 days) were placed in each striatum of some MPTP-intoxicated pigs, using MRI-based stereotactic techniques. Immunosuppression of some animals with cyclosporin and prednisolone began just prior to surgery. Two more series of PET scans were performed at 4-month intervals after surgery. After the last scans, pigs were killed and the brains were perfused for unbiased stereological examination of cytological and histochemical markers in striatum and substantial nigra. The behavioral impairment of the animals (the "Parkinson's score") had been evaluated throughout the 8-month period. Kinetic analysis of the first set of PET scans has indicated that the rate constant for the decarboxylation of FDOPA in catecholamine fibers was reduced by 33% in striatum of the mildly parkinsonian pigs. The rate of association of [11C]NS-2214 to catecholamine uptake sites was reduced by 62% in the same groups of pigs. No significant difference was found in the binding potential of [11C]raclopride to the dopamine D2-like receptors in striatum of the MPTP-intoxicated versus control pigs. These preliminary results are suggestive that the activity of DOPA decarboxylase may be upregulated in the partially denervated pig striatum.
Regulation of <i>Pax-3</i> expression in the dermomyotome and its role in muscle development (1994)

The segmented mesoderm in vertebrates gives rise to a variety of cell types in the embryo including the axial skeleton and muscle. A number of transcription factors containing a paired domain (Pax proteins) are expressed in the segmented mesoderm during embryogenesis. These include Pax-3 and a closely related gene, Pax-7, both of which are expressed in the segmental plate and in the dermomyotome. In this paper, we show that signals from the notochord pattern the expression of Pax-3, Pax-7 and Pax-9 in somites and the subsequent differentiation of cell types that arise from the somitic mesoderm. We directly assess the role of the Pax-3 gene in the differentiation of cell types derived from the dermomyotome by analyzing the development of muscle in splotch mouse embryos which lack a functional Pax-3 gene. A population of Pax-3-expressing cells derived from the dermomyotome that normally migrate into the limb are absent in homozygous splotch embryos and, as a result, limb muscles are lost. No abnormalities were detected in the trunk musculature of splotch embryos indicating that Pax-3 is necessary for the development of the limb but not trunk muscle.
Deploying and Managing a Network of Autonomous Internet Measurement Probes: Lessons Learned (2015)

We present our experience with design, development, deployment, and operation of a nation-wide network of mobile Internet measurement probes. Mobile internet is becoming increasingly important, with new technologies being deployed on a regular basis. In the last decade we have seen a transition over a multitude of data transmission technologies, from EDGE, UMTS, and HSPA to LTE, with 5G already on the horizon. This presents an extremely heterogeneous environment where problems are difficult to pinpoint, because of either the fast changing radio channel conditions, daily mobility of the user base, or a number of fallback technologies that are available at a specific location and chosen by the terminal itself. To quantify these conditions, we have developed a mobile internet measurement probe called QMON, which can be either statically deployed or used in drive measurements and is able to collect hundreds of key performance indicators on physical, network, and application layers of the network stack, acting at the same time as an event-driven real-time sensor network and a batch-mode detailed data collection device. In this paper we expose some of the design considerations and pitfalls; among them are the problems of managing and monitoring the remote probes that measure the same communication channel that is also used for their control.
Toward visual programming languages for steering scientific computations (1994)

Imagine running a computationally intensive model and being able not only to visualize the data as soon as results start emerging, but also to experiment with and change the underlying calculations in midstream, all with a consistent visual interface. This scenario represents a marriage of these two areas: visual programming languages and steering. We classified these two areas of research in six dimensions to provide insights and to suggest future research directions. The first four measure how thoroughly a system fulfils significant attributes of the requirements of a scenario (which is presented). The fifth and sixth dimensions help clarify the advantages and disadvantages of different approaches by looking at the ways they use various programming paradigms. The dimensions are: the system's steering capabilities; the power and visual extent of the interface; the level of support for preexisting scientific application programs; system generality; the programming paradigm used for scientific programming; and the programming paradigm used for visualization and steering.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis of Pyrrolo[1′,2′:1′,2′]Pyrazino-[6′,5′:4,5]Thieno[2,3-c]Pyridazine Derivatives and Related Pentacyclic Heterocycles (1994)

Abstract Ethyl-5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate(1) was converted into ethyl 3,4-diphenyl-5-(1-pyrrolyl)-thieno[2,3-c]pyridazine-6-carboxylate(2). Several derivatives of the latter compound have been synthesized. Also, the synthesis of 3,4-diphenylpyrrolo[1″,2″:1′,2′]pyrazino[6′,5′:4,5]-thieno[2,3-c]pyridazines and other related fused heterocycles are described.
Optical diffusion imaging: a comparative numerical and experimental study (1996)

We present a low-cost photodiode-LED apparatus for making broadband frequency domain photon migration measurements. We compare measured data to finite-difference frequency domain solutions of the diffusion approximation of the Boltzmann transport equation. Specific comparisons include the influence of boundary conditions on simulations and the effect of finite source size on resolution.
The finance of municipal capital expenditure in England and Wales, 1870–1914 (1997)

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Prevalence and Incidence Trends for Diagnosed Diabetes Among Adults Aged 20 to 79 Years, United States, 1980-2012 (2014)

Analyses of nationally representative data from 1980 to 2012 suggest a doubling of the incidence and prevalence of diabetes during 1990-2008, and a plateauing between 2008 and 2012. However, there appear to be continued increases in the prevalence or incidence of diabetes among subgroups, including non-Hispanic black and Hispanic subpopulations and those with a high school education or less.
Anger attacks in depressed outpatients and their response to fluoxetine. (1991)

"Anger attacks" are spells of anger that are inappropriate to the situation and have physical features resembling panic attacks. The Anger Attacks Questionnaire, designed to assess these attacks, was administered to 79 consecutive patients (25 men and 54 women, mean age 38.8 +/- 10.3 years) diagnosed as having major depression with the Structured Clinical Interview for DSM-III-R. Of these 79 depressed patients, 34 (13 men and 21 women) reported having anger attacks according to our criteria. The prevalence of anger attacks in a group of 31 younger depressed patients (48%) was significantly higher (p = .048) than that of 29 normal controls (21%) of similar age. Of the 79 depressed patients, 19 (7 men, 12 women) were treated openly with fluoxetine at 20 mg/day for at least 8 weeks. At pretreatment, 9 patients (47%) had reported anger attacks, only 3 (16%) continued to report them after treatment, and the difference was statistically significant (p less than .05).
Can fish really feel pain? (2012)

Abstract We review studies claiming that fish feel pain and find deficiencies in the methods used for pain identification, particularly for distinguishing unconscious detection of injurious stimuli (nociception) from conscious pain. Results were also frequently misinterpreted and not replicable, so claims that fish feel pain remain unsubstantiated. Comparable problems exist in studies of invertebrates. In contrast, an extensive literature involving surgeries with fishes shows normal feeding and activity immediately or soon after surgery. C fiber nociceptors, the most prevalent type in mammals and responsible for excruciating pain in humans, are rare in teleosts and absent in elasmobranchs studied to date. A‐delta nociceptors, not yet found in elasmobranchs, but relatively common in teleosts, likely serve rapid, less noxious injury signaling, triggering escape and avoidance responses. Clearly, fishes have survived well without the full range of nociception typical of humans or other mammals, a circumstance according well with the absence of the specialized cortical regions necessary for pain in humans. We evaluate recent claims for consciousness in fishes, but find these claims lack adequate supporting evidence, neurological feasibility, or the likelihood that consciousness would be adaptive. Even if fishes were conscious, it is unwarranted to assume that they possess a human‐like capacity for pain. Overall, the behavioral and neurobiological evidence reviewed shows fish responses to nociceptive stimuli are limited and fishes are unlikely to experience pain.
Mucura: your personal file repository in the cloud (2012)

Large-scale distributed data processing platforms for scientific research such as the LHC computing grid include services for transporting, storing and processing massive amounts of data. They often address the data processing needs of a virtual organization but lack the convenience and flexibility required by individual users for their personal data storage needs. This paper presents the motivation, design and implementation status of Mucura, an open source software system for operating multi-tenant cloud-based storage services. The system is specifically intended for building file repositories for individual users, such as those of the scientific research communities, who use distributed computing infrastructures for processing and sharing data. It exposes the Amazon S3-compatible interface, supports both interactive and batch usage and is compatible with the X509 certificates-based authentication mechanism used by grid infrastructures. The system builds on top of distributed persistent key-value stores for storing user's data.
Cold-Regulated Cereal Chloroplast Late Embryogenesis Abundant-Like Proteins. Molecular Characterization and Functional Analyses (2002)

Cold acclimation and freezing tolerance are the result of complex interaction between low temperature, light, and photosystem II (PSII) excitation pressure. Previous results have shown that expression of the Wcs19 gene is correlated with PSII excitation pressure measured in vivo as the relative reduction state of PSII. Using cDNA library screening and data mining, we have identified three different groups of proteins, late embryogenesis abundant (LEA) 3-L1, LEA3-L2, and LEA3-L3, sharing identities with WCS19. These groups represent a new class of proteins in cereals related to group 3 LEA proteins. They share important characteristics such as a sorting signal that is predicted to target them to either the chloroplast or mitochondria and a C-terminal sequence that may be involved in oligomerization. The results of subcellular fractionation, immunolocalization by electron microscopy and the analyses of target sequences within the Wcs19 gene are consistent with the localization of WCS19 within the chloroplast stroma of wheat (Triticum aestivum) and rye (Secale cereale). Western analysis showed that the accumulation of chloroplastic LEA3-L2 proteins is correlated with the capacity of different wheat and rye cultivars to develop freezing tolerance. Arabidopsis was transformed with the Wcs19 gene and the transgenic plants showed a significant increase in their freezing tolerance. This increase was only evident in cold-acclimated plants. The putative function of this protein in the enhancement of freezing tolerance is discussed.
The ilvIH operon of Escherichia coli is positively regulated (1990)

The ilvIH operon of Escherichia coli (located near min 2) encodes acetohydroxyacid synthase III, an isozyme involved in branched-chain amino acid biosynthesis. A strain with lacZ fused to the ilvIH promoter was constructed. Transposon Tn10 was introduced into this strain, and tetracycline-resistant derivatives were screened for those in which ilvIH promoter expression was markedly reduced. In one such derivative, strain CV1008, beta-galactosidase expression was reduced more than 30-fold. The transposon giving rise to this phenotype inserted near min 20 on the E. coli chromosome. Extract from a wild-type strain contains a protein, the IHB protein, that binds to two sites upstream of the ilvIH promoter (E. Ricca, D. A. Aker, and J. M. Calvo, J. Bacteriol. 171:1658-1664, 1989). Extract from strain CV1008 lacks IHB-binding activity. These results indicate that the IHB protein is a positive regulator of ilvIH operon expression. The gene that encodes the IHB protein, ihb, was cloned by complementing the transposon-induced mutation. Definitive evidence that the cloned DNA encodes the IHB protein was provided by determining the sequence of more than 17 amino acids at the N terminus of the IHB protein and comparing it with the nucleotide sequence. A mutation that prevents repression of the ilvIH operon by leucine in vivo and that alters the DNA-binding characteristics of the IHB protein in vitro was shown to be an allele of the ihb gene. The ihb gene is identical to oppI, a gene that regulates the oppABCDF operon (E. A. Austin, J. C. Andrews, and S. A. Short, Abstr. Mol. Genet. Bacteria Phages, p. 153, 1989). Thus, oppI/ihb encodes a protein that regulates both ilvIH, an operon that is repressed by leucine, and oppABCDF, an operon involved in peptide transport that is induced by leucine. We propose that the designation lrp be used in the future instead of oppI or ihb and that Lrp (leucine-responsive regulatory protein) be used in place of IHB.
A Simple Method for Covalent Immobilization of Proteins on Porous Silicon Surfaces (2005)

Abstract Biomolecules can be covalently grafted onto the hydride-terminated porous silicon surface through a simple three-step method: amino-silanization, attachment of succinimidyl ester, and finally immobilization of a fluoresein-labeled IgG. And each surface is characterized with transmission infrared Fourier-transform and photoluminescence spectroscopy.
Wavelength division multiplexing of continuous variable quantum key distribution and 18.3 Tbit/s data channels (2019)

Abstract Quantum key distribution (QKD) can offer communication with unconditional security and is a promising technology to protect next generation communication systems. For QKD to see commercial success, several key challenges have to be solved, such as integrating QKD signals into existing fiber optical networks. In this paper, we present experimental verification of QKD co-propagating with a large number of wavelength division multiplexing (WDM) coherent data channels. We show successful secret key generation over 24 h for a continuous-variable QKD channel jointly transmitted with 100 WDM channels of erbium doped fiber amplified polarization multiplexed 16-ary quadrature amplitude modulation signals amounting to a datarate of 18.3 Tbit/s. Compared to previous co-propagation results in the C-band, we demonstrate more than a factor of 10 increase in the number of WDM channels and more than 90 times higher classical bitrate, showing the co-propagation with Tbit/s data-carrying channels.
High-Temperature Pressure Swing Adsorption Process for CO<sub>2</sub> Separation (2011)

This paper presents a novel pressure swing adsorption process and the development of specifically designed sorbents for the process. It is operated at high temperature (650–800 °C) using the reversible reaction of calcium oxide with CO2, i.e., CaO + CO2 ⇄ CaCO3. The new process directly stores the reaction heat released from the forward reaction in the sorbent and then releases it for sorbent regeneration under reduced CO2 partial pressure, so that the need of pure oxygen for oxy-fuel combustion is avoided. Two potential problems of the new process, namely, loss in capacity and slow and unmatched reaction rates of chemical-controlled carbonation and calcination, were discussed in detail. Three specifically designed calcium-based sorbents showed stable performance during 92 isothermal carbonation–calcination cycles at either 680 or 750 °C. The calcination rate was significantly enhanced by increasing the reaction temperature and the introduction of steam to match the reaction rate of chemical-controlled carbonation. This pressure swing adsorption process could be used for low-cost CO2 separation using specifically designed sorbents under carefully selected operating conditions.
Low-cost bump-bonding processes for high energy physics pixel detectors (2016)

In the next generation of collider experiments detectors will be challenged by unprecedented particle fluxes. Thus large detector arrays of highly pixelated detectors with minimal dead area will be required at reasonable costs. Bump-bonding of pixel detectors has been shown to be a major cost-driver. KIT is one of five production centers of the CMS barrel pixel detector for the Phase I Upgrade. In this contribution the SnPb bump-bonding process and the production yield is reported. In parallel to the production of the new CMS pixel detector, several alternatives to the expensive photolithography electroplating/electroless metal deposition technologies are developing. Recent progress and challenges faced in the development of bump-bonding technology based on gold-stud bonding by thin (15 μm) gold wire is presented. This technique allows producing metal bumps with diameters down to 30 μm without using photolithography processes, which are typically required to provide suitable under bump metallization. The short setup time for the bumping process makes gold-stud bump-bonding highly attractive (and affordable) for the flip-chipping of single prototype ICs, which is the main limitation of the current photolithography processes.
Diabetic Ketoacidosis Associated With Acute Pancreatitis in a Heart Transplant Recipient Treated With Tacrolimus (2012)

New-onset diabetes mellitus after transplant is a well-recognized complication of tacrolimus immunosuppression and commonly occurs as a form of type 2 diabetes mellitus. However, tacrolimus-associated acute pancreatitis causing diabetic ketoacidosis has not been reported in heart transplant patients. We report a 22-year-old women hospitalized owing to diabetic ketoacidosis associated with acute pancreatitis 7 months after a heart transplant. Her immunosuppression included tacrolimus. She was admitted with complaints of polydipsia, anorexia, and abdominal pain of 3 days' duration. Her initial laboratory test revealed a toxic level of tacrolimus (> 30 ng/mL), severe hyperglycemia (39 mmol/L), severe metabolic acidosis (pH 6.9), and ketonuria, although diabetes mellitus had never been diagnosed. Serum amylase and lipase levels and abdominal computed tomography suggested the presence of acute pancreatitis. After correcting the diabetic ketoacidosis and getting the tacrolimus level to the normal range, she was discharged home. Three months later, insulin was replaced with oral hypoglycemic agents. Pancreatitis can present with diabetic ketoacidosis in the recipient of a heart transplant treated with tacrolimus. Clinicians should pay more attention to tacrolimus levels and the risk of pancreatitis.