gebhart/patrepeval huggingface dataset:
Fundamentals of Controlled/Living Radical Polymerization (2013)

Controlled/living radical polymerization (CRP) has revolutionized and revitalized the field of synthetic polymer chemistry over the last twenty years as it is now possible to prepare a wide variety of previously inaccessible macromolecules under relatively mild conditions. Fundamentals of Controlled/Living Radical Polymerization provides an in-depth coverage of the essential chemical principles that enable and govern each of the CRP methods. The book starts with a brief historical overview of the major findings in polymer science which eventually led to the development of living ionic and living radical systems. It then goes on to introduce the main CRP techniques including their mechanistic understanding. The book also provides the information needed to select the appropriate reagents and conditions to conduct various CRP methods in a practical setting. Therefore, in addition to a newcomer gaining an appreciation for what has already been accomplished, the reader will be armed with the tools needed to begin independent research. Fundamentals of Controlled/Living Radical Polymerization provides essential insight into a rapidly growing field that goes beyond a simple literature review of the area. Written by leading experts in the field, the book is an indispensible resource for all researchers, instructors, and students in polymer chemistry.
Blend recognition algorithm and applications (2001)

This paper reports an algorithm for the automatic recognition of blends from Boundary Representation (B-rep) solid models. The algorithm also deduces the sequence in which the blends got created in the model, and thereby helps in understanding the design intent of the model. This algorithm has been implemented as a blend recognition module of a Feature Recognition library. The novelty of the blend recognizer lies in the recognition of blends that occur in different configurations and complex blend networks. The paper also discusses various applications of blend recognition and suppression.
An efficient method of calibrating MOSFET capacitances by way of excluding intra- DUT parasitic contributions (2010)

An efficient exclusion of intra-DUT parasitic capacitances has been enabled by a combination of capacitance measurement and 3D capacitance simulation on structures with varying number of contacts per side for a MOSFET structure. Accounted for is the capacitance shift due to the presence of contact plugs, the physical shapes of which are not necessarily the same as their geometrical representations in design space.
Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F (2020)

Interleukin (IL)-17A is a key driver of inflammation and the principal target of anti-IL-17 therapeutic monoclonal antibodies. IL-17A, and its structurally similar family member IL-17F, have been shown to be functionally dysregulated in certain human immune-mediated inflammatory diseases such as psoriasis, psoriatic arthritis, and axial spondyloarthritis. Given the overlapping biology of these two cytokines, we postulated that dual neutralization of IL-17A and IL-17F may provide a greater depth of clinical response in IL-17-mediated diseases than IL-17A inhibition alone. We identified 496.g1, a humanized antibody with strong affinity for IL-17A but poor affinity for IL-17F. Affinity maturation of 496.g1 to 496.g3 greatly enhanced the affinity of the Fab fragment for IL-17F while retaining strong binding to IL-17A. As an IgG1, the affinity for IL-17A and IL-17F was 3.2 pM and 23 pM, respectively. Comparison of 496.g3 IgG1 with the commercially available anti-IL-17A monoclonal antibodies ixekizumab and secukinumab, by surface plasmon resonance and in a human <i>in vitro</i> IL-17A functional assay, showed that 496.g3 and ixekizumab display equivalent affinity for IL-17A, and that both antibodies are markedly more potent than secukinumab. In contrast to ixekizumab and secukinumab, 496.g3 exhibited the unique feature of also being able to neutralize the biological activity of IL-17F. Therefore, antibody 496.g3 was selected for clinical development for its ability to neutralize the biologic function of both IL-17A and IL-17F and was renamed bimekizumab (formerly UCB4940). Early clinical data in patients with psoriasis, in those with psoriatic arthritis, and from the Phase 2 studies in psoriasis, psoriatic arthritis, and ankylosing spondylitis, are encouraging and support the targeted approach of dual neutralization of IL-17A and IL-17F. Taken together, these findings provide the rationale for the continued clinical evaluation of bimekizumab in patients with immune-mediated inflammatory diseases.
Formation stress determination from borehole acoustic logging: A theoretical foundation (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999Formation stress determination from borehole acoustic logging: A theoretical foundationAuthors: X. M. TangN. Y. ChengArthur C. H. ChengX. M. TangBaker Atlas, Houston, Texas, N. Y. ChengBaker Atlas, Houston, Texas, and Arthur C. H. ChengBaker Atlas, Houston, Texashttps://doi.org/10.1190/1.1821086 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1821086FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1999ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION X. M. Tang, N. Y. Cheng, and Arthur C. H. Cheng, (1999), "Formation stress determination from borehole acoustic logging: A theoretical foundation," SEG Technical Program Expanded Abstracts : 57-60. https://doi.org/10.1190/1.1821086 Plain-Language Summary PDF DownloadLoading ...
Reducing Piston Mass in a Free Piston Engine Compressor by Exploiting the Inertance of a Liquid Piston (2009)

A dynamic model of a free liquid piston that exploits piston geometry to produce a high inertance was developed for use in a free piston engine compressor. It is shown that for the size scale targeted, advantageous piston dynamics can be achieved with a reduced piston mass compared to a rigid piston design. It is also shown that the viscous losses associated with the liquid piston are negligible for the application discussed. The slow dynamics achieved by the liquid piston also allow for reduced valve sizes for the compressor, creating a more energy-dense device on a systems level. Other advantages gained by this design compared to prior work are discussed, including the elimination of a separated combustion chamber, smaller (integrated) pump check valve, and the capability of more balanced operation for a single-piston compressor. A dynamic model of the proposed high inertance liquid piston is presented and simulation results are discussed.
IADIRA: Inertial Aided Deeply Integrated Receiver Architecture (2006)

The Galileo Joint Undertaking 2nd Call, in the frame of the Research and Development activities related to the Galileo Programme, provides the ground to support research institutes and SME’s on key technological development. In this context, DEIMOS Engenharia and the Institut de Geomatica are conducting the IADIRA study for improvements and further possibilities on hybridisation techniques. Previous Galileo Phases studies, such as Galilei, already identified the possibilities to integrate the future Galileo system with other systems and sensors, which might lead to a significant enhancement of its performance. It is well known that use of GNSS will be heavily dependent on sensor hybridisation, accurate digital maps and Local Elements. The innovative IADIRA project focuses in the field of inertial aiding, referring to the use of inertial-derived position and velocity for the improvement of the GNSS receiver tracking loops, interpolate GNSS trajectories for short periods, be it because of GNSS data gaps or just to interpolate between GNSS fixes. The main study objective is to explore the inertial aiding of the future Galileo or Galileo/GPS receivers as this aspect of the future Galileo technology has not yet been explored. More specifically, we present results of how MEMS Miniature Inertial Measurement Units can be seamless and transparently integrated into GNSS receiver antennas through an tightly coupled or deeply integrated architecture. To analyse and demonstrate the concept a test-bench is developed and the receiver is prototyped in a sample-based (bit-true) Galileo software receiver based on GRANADA receiver [1] coupled to the combined GNSS-Inertial software. Real or simulated IMU data provides the required inertial sensor measurements. Reference trajectories are obtained using navigation grade IMU and used to generate receiver Doppler profiles, providing a truth reference to measure the performance increase when using inertial aiding of IADIRA concept.
Pilot Demonstration of Energy‐Efficient Membrane Bioreactor (MBR) Using Reciprocating Submerged Membrane (2015)

Membrane bioreactor (MBR) is becoming popular for advanced wastewater treatment and water reuse. Air scouring to "shake" the membrane fibers is most suitable and applicable to maintain filtration without severe and rapidfouling. However, membrane fouling mitigating technologies are energy intensive. The goal of this research is to develop an alternative energy-saving MBR system to reduce energy consumption; a revolutionary system that will directly compete with air scouring technologies currently in the membrane water reuse market. The innovative MBR system, called reciprocation MBR (rMBR), prevents membrane fouling without the use of air scouring blowers. The mechanism featured is a mechanical reciprocating membrane frame that uses inertia to prevent fouling. Direct strong agitation of the fiber is also beneficial for the constant removal of solids built up on the membrane surface. The rMBR pilot consumes less energy than conventional coarse air scouring MBR systems. Specific energy consumption for membrane reciprocation for the pilot rMBR system was 0.072 kWh/m3 permeate produced at 40 LMH, which is 75% less than the conventional air scouring in an MBR system (0.29 kWh/m3). Reciprocation of the hollow-fiber membrane can overcome the hydrodynamic limitations of air scouring or cross-flow membrane systems with less energy consumption and/or higher energy efficiency.
Organic functionalization of mesopore walls in hierarchically porous zeolites (2008)

Mesopore walls of hierarchically meso-/microporous zeolites (MFI, BEA and LTA) are covered with silanol groups, so that the zeolites can be functionalized with various organic groups via silylation; the organic-functionalized hierarchical zeolites exhibit hydrothermal stability and reusability in catalytic applications, as compared with organic-functionalized mesoporous silica.
ChemInform Abstract: Stereocontrolled Synthesis of (E,Z)‐Dienals via Tandem Rh(I)‐Catalyzed Rearrangement of Propargyl Vinyl Ethers. (2014)

Abstract Propargyl vinyl ethers undergo Rh‐catalyzed Claisen rearrangement followed by stereoselective proton transfer to provide (E,Z)‐dienals.
Soy Flour Substitution in Polymeric Methylene Diphenyl Diisocyanate Resin for Composite Panel Applications (2020)

Abstract Partial substitution of polymeric methylene diphenyl diisocyanate (pMDI) resin by 10 to 15 percent soy flour for the manufacture of strand board improves board properties while decreasing cost. For particleboard and medium-density fiberboard the soy-substituted resin performs as well as the control pMDI. The reaction of soy flour with pMDI occurs over several hours as tracked by CO 2 evolution. The soy-amended resin must be used within about 30 minutes of formulation. Uniform mixing of soy flour with pMDI is critical because unreacted soy flour tends to retain water, which degrades the wet properties of the board. The soy flour increases the tack of pMDI resin, which increases the surface coverage and the relative bonded area at the glue line.
Auto-join (2017)

Traditional equi-join relies solely on string equality comparisons to perform joins. However, in scenarios such as ad-hoc data analysis in spreadsheets, users increasingly need to join tables whose join-columns are from the same semantic domain but use different textual representations, for which transformations are needed before equi-join can be performed. We developed Auto-Join, a system that can automatically search over a rich space of operators to compose a transformation program, whose execution makes input tables equi-join-able. We developed an optimal sampling strategy that allows Auto-Join to scale to large datasets efficiently, while ensuring joins succeed with high probability. Our evaluation using real test cases collected from both public web tables and proprietary enterprise tables shows that the proposed system performs the desired transformation joins efficiently and with high quality.
Estimating facial pose from a sparse representation (2005)

We present an approach to estimate the poses off human heads in natural scenes. The essential features for estimating the head pose are the positions of the prominent facial features relative to the position of the head. We have developed a high-dimensional, randomly sparse representation of a human face using a simplified facial feature model. The representation transforms a raw face image into a vector, representing how well the image matches a large number of randomly-posed and shaped head models. This transformation is designed to collect salient features of the face image that are useful to estimate the pose, while suppressing any irrelevant variations of face appearance. The relation between the sparse representation and the pose is learned using SVR (support vector regression). The sparse representation combined with SVR is shown to estimate the pose more quickly and accurately than SVR applied to raw images.
A hybrid model and measurement based connection admission control and bandwidth allocation scheme for ATM networks (2002)

We extend the earlier work of Ramamurthy and Ren (see IEEE INFOCOM'97, 1997) and develop a dynamic connection admission control (CAC) scheme that supports cell loss requirements. The CAC algorithm explicitly computes the equivalent bandwidth required to support each class of connections based on on-line observations of aggregate traffic statistics as well as the declared parameters. We use Gaussian and diffusion approximations to characterize the aggregate traffic stream. Through careful analysis and collection of statistics, we derive simple closed-form formulas to estimate the equivalent bandwidth in real time. We validate the proposed algorithms for various VBR traffic profiles and show that the system utilization can be substantially improved by appropriately combining traffic characteristics deduced from the declared parameters and traffic measurements.
Antitumor Agents. 181. Synthesis and Biological Evaluation of 6,7,2‘,3‘,4‘-Substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents (1998)

A novel series of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl- 4-quinolones were synthesized and evaluated for interactions with tubulin and for cytotoxic activity against a panel of human tumor cell lines, including ileocecal carcinoma (HCT-8), breast cancer (MCF-7), lung carcinoma (A-549), epidermoid carcinoma of the nasopharynx (KB), renal cancer (CAKI-1), and melanoma cancer (SKMEL-2). Most compounds (18, 20, 22-27) showed potent cytotoxic and antitubulin effects. The most active compounds (23, 26, 27) demonstrated strong cytotoxic effects with ED50 values in the nanomolar or subnanomolar range in almost all tumor cell lines. Three active racemates (20, 22, 25) were separated into the enantiomers, and generally, the optically pure (-)-isomers (20a, 22a, 25a) exhibited greater biological activity than the racemates or (+)-isomers. Cytotoxicity and antitubulin activity were closely correlated, with the most active compounds (23, 26, 27) having effects comparable to those of colchicine, podophyllotoxin, and combretastatin A-4.
The protein DIIIC‐2, aggregated with a specific oligodeoxynucleotide and adjuvanted in alum, protects mice and monkeys against DENV‐2 (2014)

Previously, we reported the ability of the chimeric protein DIIIC-2 (domain III of the dengue envelope protein fused to the capsid protein of dengue-2 virus), to induce immunity and protection in mice, when it is highly aggregated with a non-defined oligodeoxynucleotide (ODN) and adjuvanted in alum. In this work, three different defined ODNs were studied as aggregating agents. Our results suggest that the nature of the ODN influences the capacity of protein DIIIC-2 to activate cell-mediated immunity in mice. Consequently, the ODN 39M was selected to perform further experiments in mice and nonhuman primates. Mice receiving the preparation 39M-DIIIC-2 were solidly protected against dengue virus (DENV) challenge. Moreover, monkeys immunized with the same preparation developed neutralizing antibodies, as measured by four different neutralization tests varying the virus strains and the cell lines used. Two of the immunized monkeys were completely protected against challenge, whereas the third animal had a single day of low-titer viremia. This is the first work describing the induction of short-term protection in monkeys by a formulation that is suitable for human use combining a recombinant protein from DENV with alum.
Nanofiber-segment ring resonator (2016)

We describe a fiber ring resonator comprised of a relatively long loop of standard single-mode fiber with a short nanofiber segment. The evanescent mode of the nanofiber segment allows the cavity-enhanced field to interact with atoms in close proximity to the nanofiber surface. We report on an experiment using a warm atomic vapor and low-finesse cavity, and briefly discuss the potential for reaching the strong coupling regime of cavity QED by using trapped atoms and a high-finesse cavity of this kind.
Abstract A28: Targeting the epigenetic state regulating cancer cell vulnerability to proteasome inhibition (2017)

Abstract The proteasome is a central regulator of protein homeostasis in all eukaryotes. Targeted pharmaceutical inhibition of the proteasome complex has been implemented as a successful therapeutic strategy to treat several cancers including multiple myeloma. Unfortunately, many of the cancers show intrinsic resistance to proteasome inhibitors, and those that are initially responsive eventually develop resistance by a poorly understood mechanism. We have recently performed genome-wide screens for mutations that allowed cells to survive in the presence of two distinct proteasome inhibitors (bortezomib and MG132). Counter to expectation, we have shown that reducing any one of the many of the subunits of the regulatory cap complex (19S) is sufficient to alter both the levels and ratio of the 26S/20S proteasome complex and induce increased resistance to proteasome inhibition. These findings motivated us to establish a cell-based screening strategy to identify molecules that specifically target the proteasome inhibitor (PI)-resistant state. We further exploited the Genomics of Drug Sensitivity in Cancer (GDSC) database to analyze the efficacy of PIs across 315 cancer cell lines for which we also had matched gene expression data. This analysis revealed that a significant decrease in the gene expression of one component of the 19S complex is both naturally occurring (in almost 6-8% of cells examined) and is sufficient to predict resistance to PIs. We termed these cells, proteasome HYDRA (Hypo expression Yielding Drug Resistance Ability) cancer cells. Further exploring the HYDRA cells utilizing the Cancer Cell Line Encyclopedia (CCLE) dataset revealed that the loss of expression of the proteasome subunit is not associated with a loss of gene copy number but rather is an epigenetic mechanism of reduced gene expression. We show here a novel cellular epigenetic switch utilized by many cancer cells that renders them resistant to proteotoxic stress. Our findings enable prediction of cancer cell vulnerability to proteasome function perturbation and also facilitate the specific targeting of this unique epigenetic state by selective drug treatment. Citation Format: Peter Tsvetkov, Ethan Sokol, Dexter Jin, Piyush Gupta, Sandro Santagata, Luke Whitesell, Susan Lindquist. Targeting the epigenetic state regulating cancer cell vulnerability to proteasome inhibition. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr A28.
Conformal antenna using Circular Microstrip patches in C band (2016)

This paper presents designing of a conformal antenna using a number of Microstrip Circular patches in C band frequency range i.e. 4 GHz to 8 GHz. The designed antenna array comprises of 4 elements with a uniform spacing conformed on a cylindrical surface of radius 42.9799 mm. The analysis is done via MATLAB (Phased Array System Toolbox) and the equivalent design also has been verified using the HFSS 3D simulation tool. Conformal antenna with the bandwidth of 0.4124 GHz, Gain of 3.7697 dB, Return Loss of -16.3353 dB, VSWR <; 2 with Co- Polarization of +27.5 dB and Cross Polarization of +2.5 dB, operating at a frequency of 5.8 GHz is designed. This compact antenna is capable of providing 3600 coverage due to its conformability.
Surface-Permanent-Magnet Synchronous Machine Design for Saliency-Tracking Self-Sensing Position Estimation at Zero and Low Speeds (2011)

Elimination of externally mounted position sensors and their associated cables is a goal for drive manufacturers. This paper addresses design methods of surface-permanent-magnet (SPM) synchronous machines for saliency-tracking self-sensing (position sensorless) position estimation. Machine spatial saliency is created by stator magnetic saturation due to the rotor zigzag leakage flux from SPMs. Using the machine saliency created by zigzag leakage flux can allow an SPM machine to be suitable for saliency-tracking position estimation without the need of any special rotor design modification. In addition, another major benefit is achieved, i.e., a saliency role reversal whereby L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> >; L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</sub> . This has the advantage of reducing machine cross-saturation and increasing the feasible region for closed-loop self-sensing control. All the design procedures are verified by the finite-element analysis, and a 50-W SPM machine is used for experimental evaluation.