gebhart/patrepeval huggingface dataset:
Glucocerebrosidase genotype of Gaucher patients in The Netherlands: Limitations in prognostic value (1997)

Gaucher disease is a recessively inherited lysosomal storage disorder that is caused by a deficiency in glucocerebrosidase activity. The clinical expression is markedly heterogeneous with respect to age of onset, progression, severity, and neurological involvement. The relative incidence of glucocerebrosidase (GC) mutations has been studied extensively for Jewish but not for non-Jewish Caucasian patient populations. The present survey on mutant GC genotypes prevalent in Gaucher disease in The Netherlands was taken of 72 patients from different genetic backgrounds. This number is more than half the total number of affected Gaucher patients to be expected on the basis of the incidence of the disorder in this country. Analysis of nine GC mutations led to the identification of 74% of the mutant GC alleles in patients from 44 unrelated Dutch families (i.e., families that have lived in The Netherlands for at least several generations) and of 44% of the mutant GC alleles in patients from nine unrelated families that recently immigrated from both European and non-European countries. The N370S (cDNA 1226G) GC mutation proved to occur most frequently (41%) in the unrelated Dutch patients and less frequently (6%) in the unrelated immigrant patients and was always associated with the nonneuronopathic (Type 1) form of the disease. Apart from the association of the N370S mutation with Type 1 Gaucher disease, the prognostic value of GC genotyping was limited, since a particular GC genotype did not correlate closely to a specific clinical course, or to a specific relative responsiveness to enzyme-supplementation therapy.
Time course of the change in subjective straight-ahead after vestibular stimulation (2008)

We measured the change in subjective straight-ahead (SSA) as a function of time after vestibular stimulation. Blindfolded subjects were exposed to sudden stops after constant velocity (72 degrees/s) z-axis rotation. They were then asked to open their eyes and continuously adjust the position of a laser spot to the position perceived as straight ahead (visual localization of SSA) immediately, or after a 10 s or 20 s delay following the sudden stop. The deviation of SSA increased to 20 s in the opposite direction of acceleration and then decreased gradually when the visual localization task was started immediately after sudden stops. The time courses changed systematically when the task was started after a delay of 10 s or 20 s following sudden stops: the initial increase component and maximum magnitude of the SSA deviation fell off with delay length, but the increase-decrease pattern was preserved. These delay effects on the time course of the SSA deviation might reflect that the velocity-to-orientation/position integrator for perception of body orientation in vestibular system might be inactivated temporarily during the delay period after vestibular stimulation without visual input.
Nonlinear effects of localized absorption perturbations on the light distribution in a turbid medium (1998)

A theoretical model of photon propagation in a scattering medium is presented, from which algebraic formulas for the detector-reading perturbations (delta R) produced by one or two localized perturbations in the macroscopic absorption cross section (delta mu a) are derived. Examination of these shows that when delta mu a is titrated from very small to large magnitudes in one voxel, the curve traced by the corresponding delta R values is a rectangular hyperbola. Furthermore, while delta Rinfinity identical to lim delta mu a-->infinity delta R is dependent on the location of the detector with respect to the source and the voxel, the ratio delta R/ delta Rinfinity is independent of the detector location. We also find that when delta mu a is varied in two voxels simultaneously, the quantity delta R (delta mu a,1 [symbol: see text] delta mu a,2) is a bilinear rational function of the delta mu aS. These results apply not only in the case of steady-state illumination and detection but to time-harmonic measurements as well. The validity of the theoretical formulas is demonstrated by applying them to the results of selected numerical diffusion computations. Potential applications of the derived expressions to image-reconstruction problems are discussed.
DL-Tags: DLT and Smart Tags for Decentralized, Privacy-Preserving, and Verifiable Supply Chain Management (2019)

Supply chain management enhanced by the Internet of Things (IoT) solutions integrate special tags (e.g., RFID, NFC, and QR-codes) with products to create Smart Tags, in addition to storing supplemental information about a product, which is also used to track products during their lifecycle. However, a product consumer has to implicitly trust the Smart Tag creator and other stakeholders within the supply chain that they are providing authentic data within a product's tag. The DL-Tags solution steps into this environment to offer a decentralized, privacy-preserving, and verifiable management of Smart Tags during a product's lifecycle. The solution is based on distributed ledger technology (DLT) and uses the Ethereum blockchain to mediate interactions between the stakeholders during a product's exchange process. By reaching a consensus on the product's description and state logged on the blockchain, all involved stakeholders and product consumers can verify the product's authenticity without revealing their identity. The paper describes the DL-Tags solution and includes a cost analysis of all implemented transactions on the Ethereum blockchain. The proposed solution provides evidence of the product's origin and its journey across the supply chain while preventing tag duplication and manipulation. It is among the first documented practical solutions using DLT and IoT for supply chain management, which is designed to be distributed ledger agnostic.
The origins and evolution of freeze-etch electron microscopy (2011)

The introduction of the Balzers freeze-fracture machine by Moor in 1961 had a much greater impact on the advancement of electron microscopy than he could have imagined. Devised originally to circumvent the dangers of classical thin-section techniques, as well as to provide unique en face views of cell membranes, freeze-fracturing proved to be crucial for developing modern concepts of how biological membranes are organized and proved that membranes are bilayers of lipids within which proteins float and self-assemble. Later, when freeze-fracturing was combined with methods for freezing cells that avoided the fixation and cryoprotection steps that Moor still had to use to prepare the samples for his original invention, it became a means for capturing membrane dynamics on the millisecond time-scale, thus allowing a deeper understanding of the functions of biological membranes in living cells as well as their static ultrastructure. Finally, the realization that unfixed, non-cryoprotected samples could be deeply vacuum-etched or even freeze-dried after freeze-fracturing opened up a whole new way to image all the other molecular components of cells besides their membranes and also provided a powerful means to image the interactions of all the cytoplasmic components with the various membranes of the cell. The purpose of this review is to outline the history of these technical developments, to describe how they are being used in electron microscopy today and to suggest how they can be improved in order to further their utility for biological electron microscopy in the future.
A streaming framework for seamless building reconstruction from large-scale aerial LiDAR data (2009)

We present a streaming framework for seamless building reconstruction from huge aerial LiDAR point sets. By storing data as stream files on hard disk and using main memory as only a temporary storage for ongoing computation, we achieve efficient out-of-core data management. This gives us the ability to handle data sets with hundreds of millions of points in a uniform manner. By adapting a building modeling pipeline into our streaming framework, we create the whole urban model of Atlanta from 17.7 GB LiDAR data with 683 M points in under 25 hours using less than 1 GB memory. To integrate this complex modeling pipeline with our streaming framework, we develop a state propagation mechanism, and extend current reconstruction algorithms to handle the large scale of data.
Enantioselective Total Synthesis of Macrolide Antitumor Agent (−)-Lasonolide A (2007)

[structure: see text] An enantioselective total synthesis of (-)-lasonolide A is described. The upper tetrahydropyran ring was constructed stereoselectively by an intramolecular 1,3-dipolar cycloaddition reaction. The bicyclic isooxazoline led to the tetrahydropyran ring as well as the quaternary stereocenter present in the molecule. The lower tetrahydropyran ring was assembled by a catalytic asymmetric hetero-Diels-Alder reaction as the key step. Three stereocenters were enantioselectively installed in this single step reaction.
Preliminary Study of the Interaction of Metal Nanoparticle-containing Poly-p-xylylene films With Ammonia (1997)

The interaction of metal particles encapsulated in poly-p-xylylene films and the gas phase NH 3 molecules has been studied. It has been found that in the presence of NH 3 the resistivity of the lead-containing samples could be reversibly changed by a factor of 6–8 within a few seconds. As a result, it is suggested that these materials could be used as sensors for ammonia detection in the gas phase. The response and recovery times, temperature dependence, and long-term stability of these sensors have been examined.
A high frequency GaAs multivibrator IC (2003)

In an optical disk system, a high-frequency laser diode modulator has been required to reduce the optical feedback noise. A GaAs multivibrator IC has been developed for this requirement. The IC includes a multivibrator, a buffered amplifier, and a laser driver. All these circuits are designed using the same common-drain configuration for monolithic integration in a chip size of 1.3*10 mm/sup 2/. The IC oscillates in the frequency range of 560+or-40 MHz with a power output range of 5+or-1 dBm. A noise reduction of over 6 dB was obtained by applying the IC to the optical disk system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<title>Kilowatt-range high-repetition-rate excimer lasers</title> (1991)

High-power operation of excimer lasers was investigated using UV-preionization schemes based on a dielectric surface creeping discharge. The design and operation of the high average power excimer laser systems are described. A large-aperture (10 X 7 cm2) XeCl laser with UV preionization can produce 10 J per pulse at a repetition rate of up to 100 Hz. When the aperture was decreased, the XeCl laser operated at repetition rates of up to 500 Hz and could produce average output power of more than 600 W.
Automatic skin lesion segmentation by coupling deep fully convolutional networks and shallow network with textons (2019)

Segmentation of skin lesions is an important step in computer-aided diagnosis of melanoma; it is also a very challenging task due to fuzzy lesion boundaries and heterogeneous lesion textures. We present a fully automatic method for skin lesion segmentation based on deep fully convolutional networks (FCNs). We investigate a shallow encoding network to model clinically valuable prior knowledge, in which spatial filters simulating simple cell receptive fields function in the primary visual cortex (V1) is considered. An effective fusing strategy using skip connections and convolution operators is then leveraged to couple prior knowledge encoded via shallow network with hierarchical data-driven features learned from the FCNs for detailed segmentation of the skin lesions. To our best knowledge, this is the first time the domain-specific hand craft features have been built into a deep network trained in an end-to-end manner for skin lesion segmentation. The method has been evaluated on both ISBI 2016 and ISBI 2017 skin lesion challenge datasets. We provide comparative evidence to demonstrate that our newly designed network can gain accuracy for lesion segmentation by coupling the prior knowledge encoded by the shallow network with the deep FCNs. Our method is robust without the need for data augmentation or comprehensive parameter tuning, and the experimental results show great promise of the method with effective model generalization compared to other state-of-the-art-methods.
Methylphenidate for Apathy in Community-Dwelling Older Veterans With Mild Alzheimer’s Disease: A Double-Blind, Randomized, Placebo-Controlled Trial (2017)

Methylphenidate improved apathy in a group of community-dwelling veterans with mild Alzheimer's disease. Methylphenidate also improved cognition, functional status, caregiver burden, CGI scores, and depression.
Inhibitory Effects of Curcumin and Tetrahydrocurcuminoids on the Tumor Promoter‐induced Reactive Oxygen Species Generation in Leukocytes <i>in vitro</i> and <i>in vivo</i> (1998)

The inhibitory effects of curcumin and two tetrahydrocurcuminoids on tumor promoter-induced oxidative stress in vitro and in vivo were investigated. Curcumin, tetrahydrocurcumin (THC) and dihydroxytetrahydrocurcumin (DHTHC) exhibited significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced O2-generation in differentiated HL-60 cells. The inhibitory activity of THC was weaker than that of curcumin. This tendency was the inverse of the results of previous studies on in vitro antioxidative activity against lipid peroxidation. The curcuminoids inhibited TPA-induced intracellular peroxide formation in differentiated HL-60 cells. THC exhibited much weaker inhibition of intracellular peroxide formation than curcumin, suggesting that this inhibition might be attributable to the inhibition of O2-generation. The inhibitory effects of curcuminoids on TPA-induced H2O2 formation in female ICR mouse skin were further examined using the double-TPA-application model. Each TPA application induces two distinct biochemical events, 1) recruitment of inflammatory cells to the inflammatory regions and 2) activation of oxidant-producing cells. Double pretreatment of mice with curcuminoids before each TPA treatment significantly suppressed double TPA application-induced H2O2 formation in the mouse skin. Coadministrations of curcumin with either first or second TPA treatment significantly inhibited H2O2 formation. In addition, THC tends to show weaker inhibitory activities than curcumin in bioassays related to tumor promotion, i.e., inhibition of tumor promoter-induced inflammation in mouse skin and Epstein-Barr virus activation. These tendencies were parallel to those in the tumor-suppressive potential of curcumin and THC in mouse skin, as previously reported. Thus, we concluded that curcuminoids significantly suppress TPA-induced oxidative stress via both interference with infiltration of leukocytes into the inflammatory regions and inhibition of their activation.
Rabeprazole sodium delayed-release multiparticulates: Effect of enteric coating layers on product performance (2011)

Rabeprazole sodium is one of the most effective proton pump inhibitors (PPIs) used in antiulcer therapy. Like most other PPIs, owing to its acid-labile nature, the drug is formulated as enteric-coated dosage form. Conventional means of producing delayed release multiparticulate dosage forms of PPIs require large quantities of enteric polymer coatings. In the present study, in order to better evaluate the effect of polymeric coating on product performance, the pellet core structure and composition was kept constant. Four different enteric-coating formulations and designs were evaluated. Enteric-coated drug multiparticulates prepared with single polymeric coatings (acrylic or cellulosic) were compared with two different polymeric layer coatings to evaluate the effectiveness of latter coatings in more effectively producing a better rabeprazole sodium delayed-release pellet product. The pH-dependent, enteric acrylic, and cellulosic polymers were used either alone, in combination, or applied one over the other to impart delayed-release properties to the core drug pellets. It was demonstrated that dual delayed-release coating with two different enteric polymers-an inner acrylic coating followed by an outer cellulosic coating-yields the best product that provides all the desired physicochemical and drug dissolution characteristics.
MIMO antenna with built‐in circular shaped isolator for sub‐6 GHz 5G applications (2018)

A four‐port MIMO antenna design focused on the sub‐6 GHz fifth generation wireless communication application is presented. The design does not need any other decoupling structure for achieving isolation between multiple ports. A combination of four single wideband antenna units results in the formation of a circular‐shaped metallic disc in the ground plane of the proposed antenna. This disc acts as a pool of current with 180° phase difference leading to isolation between various ports. Diversity performance of the antenna is shown with the help of an envelope correlation coefficient using both S‐parameter and far‐field data. The radiation pattern of the proposed antenna has four lobes in four quadrants for proper reception of signals from different directions. A prototype of the designed antenna is fabricated and measured successfully.
Chemotherapy induces or increases expression of multidrug resistance-associated protein in malignant melanoma cells (2001)

These results suggest that a significant mRNA level of MRP gene was intrinsically present in malignant melanoma even before exposure to chemotherapeutic drugs and increased in its expression after chemotherapy, suggesting that MRP plays a part in increasing the chemoresistance of malignant melanoma during chemotherapy.
Isolation and characterization of antimicrobial substance macrolactin A produced from Bacillus amyloliquefaciens CHO104 isolated from soil (2004)

A strain antagonistic to Fusarium solani, CHO104, was selected from approximately 100 microorganisms isolated from soil. Strain CHO104 was identified as Bacillus amyloliquefaciens and found to be Gram-positive based on the Biolog system and 16S rRNA methods. A culture broth of B. amyloliquefaciens CHO104 also exhibited antimicrobial activity against various microorganisms. As such, the EtOAc extract of the culture broth was isolated by various column chromatographic procedures and HPLC. The antimicrobial and antifungal substance was then characterized as macrolactin A (C 24 H 34 O 5 ) using high-resolution EI-MS and NMR analyses, and found to be very effective in inhibiting the growth of Staphylococcus aureus, E. coli, and Botrytis cinerea, even when using a concentration of one-twentieth of the benzoic acid as the control compound.
Debugging OpenStack Problems Using a State Graph Approach (2016)

It is hard to operate and debug systems like OpenStack that integrate many independently developed modules with multiple levels of abstractions. A major challenge is to navigate through the complex dependencies and relationships of the states in different modules or subsystems, to ensure the correctness and consistency of these states. We present a system that captures the runtime states and events from the entire OpenStack-Ceph stack, and automatically organizes these data into a graph that we call system operation state graph (SOSG). With SOSG we can use intuitive graph traversal techniques to solve problems like reasoning about the state of a virtual machine. Also, using a graph-based anomaly detection, we can automatically discover hidden problems in OpenStack. We have a scalable implementation of SOSG, and evaluate the approach on a 125-node production OpenStack cluster, finding a number of interesting problems.
Extraction of Web Information Using W4F Wrapper Factory and XML-QL Query Language (1999)

In many ways, the Web has become the largest knowledge base known to us. The problem facing the user now is not that the information he seeks is not available, but that it is not easy for him to extract exactly what he needs from what is available. It is also becoming clear that a top down approach of gathering all the information, and structuring it will not work, except in some special cases. Indeed, most of the information is present in HTML documents structured only for visual content. Instead, new tools are being developed that attack this problem from a different angle. XML is a language that allows the publisher of the data to structure it using markup tags. These mark-up tags clarify not only the visual structure of the document, but also the semantic structure. Additionally, one can make use of a query language XML-QL to query XML pages for information, and to merge information from disparate XML sources. However, most of the content of the web is published in HTML. The W4F system allows us to construct wrappers that retrieve web pages, extract desired information using the HTML structure and regular expression search and map it automatically to XML with its XML-Gateway feature. In this thesis, we investigate the W4F/XML-QL paradigm to query the web. Two examples are presented. The first is the Internet Movie Database, and we query it with the idea of understanding the power of these
The Grass Seed Pathogen Pyrenophora semeniperda as a Biocontrol Agent for Annual Brome Grasses (2009)

Bromus tectorum and other annual brome grasses have invaded many ecosystems of the western United States, and because of an annual-grass influenced alteration of the natural fire cycle on arid western range lands near monocultures are created and conditions in which the native vegetation cannot compete are established. Each year thousands of hectares become near monocultures of annual brome grasses. Pyrenophora semeniperda, a generalist seed pathogen of annual grasses, shows major potential as a possible mycoherbicide that could help in reducing the monocultures created by annual grasses. The purpose of this research was to identify the requirements for isolating cultures of P. semeniperda, search for a hypervirulent strain, and evaluate its effect in the field. The techniques for isolating the fungus have evolved and become more efficient. The first two years of working with P. semeniperda resulted in 11 isolates. During the third year of this study, we developed a single spore isolation technique that resulted in 480 additional isolates. Virulence screening resulted in detection of a range of isolate ability to kill non-dormant B. tectorum seeds. Ninety-two isolates represented a range of virulence from 0-44%. The variation in virulence was expressed mostly within populations rather than between populations. Similarly, virulence varied significantly within Internal Transcribed Spacer (ITS) genotypes and habitats but not between them. When conidial inoculum was applied in the field there was no observed difference in disease incidence between different levels of inoculum. This is thought to have been due to applying the inoculum under conditions in which most in situ seeds were infected and killed by already high field inoculum loads. While additional field trials are needed to optimize the inoculum effectiveness, the overall results of this research provide a good foundation for using P. semeniperda as a biological control for seed banks of annual brome grasses.
한국형 진단 프로토콜을 이용한 3～5세 한국 아동의 초기읽기 발달연구 (2008)

본 연구는 3～5세 한국 일반아동의 초기읽기기술(인쇄물인식, 낱글자 구별, 글자소 이름대기, 음절읽기, 음운 인식, 창안적 쓰기)의 발달특성을 살펴보고 분석함으로써 읽기문제를 가진 한국 아동들의 조기선 별을 위한 평가모형 개발의 기초자료를 제공하고자 하였다. 방법: 3～5세 한국 일반아동 180명을 대상으로 초기읽기기술 과제들을 실시하여 성별과 연령에 따른...