gebhart/patrepeval huggingface dataset:
Neovascular Age-Related Macular Degeneration and Its Association With LOC387715 and Complement Factor H Polymorphism (2007)

The AMD cases possessing the LOC387715 (rs10490924) variant may have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD.
ActiveSLA (2011)

The system overload is a common problem in a Database-as-a-Serice (DaaS) environment because of unpredictable and bursty workloads from various clients. Due to the service delivery nature of DaaS, such system overload usually has direct economic impact on the service provider, who has to pay penalties if the system performance does not meet clients' service level agreements (SLAs). In this paper, we investigate techniques that prevent system overload by using admission control. We propose a profit-oriented admission control framework, called ActiveSLA, for DaaS providers. ActiveSLA is an end-to-end framework that consists of two components. First, a prediction module estimates the probability for a new query to finish the execution before its deadline. Second, based on the predicted probability, a decision module determines whether or not to admit the given query into the database system. The decision is made with the profit optimization objective, where the expected profit is derived from the service level agreements between a service provider and its clients. We present extensive real system experiments with standard database benchmarks, under different traffic patterns, DBMS settings, and SLAs. The results demonstrate that ActiveSLA is able to make admission control decisions that are both more accurate and more profit-effective than several state-of-the-art methods.
An Accelerometer Based Instrumentation of the Golf Club: Measurement and Signal Analysis (2010)

Two accelerometers are used to measure the motion of the golf club. The accelerometers are mounted in the shaft of the golf club. Each measures the acceleration along the axis of the shaft of the golf club. Interpreting the measurement with the context of the double pendulum model of the golf swing, it is useful to resolve the resulting signals into differential and common mode components. The differential mode is a measure of the rotational kinetic energy of the golf club, and this can be used to understand the tempo, rhythm, and timing of the golf swing. The common mode measurement is related to the motion of the hands. It is shown that both components can be used to recover the motion of the swing within the context of the double pendulum model of the golf swing.
An 18-21 GHz InP DHBT linear microwave Doherty amplifier (2002)

This work describes the first demonstration of an InP DHBT MMIC Doherty amplifier at K-band. When combined with InP DHBTs, the Doherty amplifier achieves a record linear PAE of 20% under a strict C/IM3 linearity ratio of 30 dBc while producing a Pout of 20.1 dBm. This benchmarks 3 dB greater Pout and 4% higher linear PAE than achieved with a PHEMT MMIC Doherty amplifier at Ku-band for the same C/IM3 linearity. Compared to its own linear "class A" bias performance, the Doherty amplifier achieves an 11 dB improvement in C/IM3 for the same Pout and slightly greater efficiency. The superior linearity of the InP DHBT Doherty amplifier approach is attractive for satellite and MM-wave communication systems.
A design of transform coder for both speech and audio signals at 1 bit/sample (1997)

This paper proposes a speech and audio coder which operates at 1 bit/sample, namely an 8 kbit/s coder for 8 kHz sampling or a 16 kbit/s coder for 16 kHz sampling. The basic structure is inherited from a Twin VQ (transform domain weighted interleave vector quantization) high-quality audio coding scheme. A periodical component extraction scheme is newly added to the quantization of the MDCT coefficients. This scheme is found to be effective for reducing distortion and improving the robustness against channel errors. The qualities for music signals at 8 kbit/s are better than those of G.729 at the same bit rates, while they are worse for clean speech. The qualities at 16 kbit/s are comparable to or better than those of G.722 at 48 kbit/s.
Fabrication and characterisation of 200 mm germanium-on-insulator (GeOI) substrates made from bulk germanium (2006)

The formation and detailed characterisations of a 200 mm germanium-on-insulator substrate made from germanium bulk material as donor wafer using the Smart CutTM technology is reported. Detailed characterisations of final GeOI structures are presented: final roughness, defectivity evaluation, thickness measurement, and electrical characterisation.
SQUID-Detected in vivo MRI at Microtesla Magnetic Fields (2005)

We use a low transition temperature (T/sub c/) Super-conducting Quantum Interference Device (SQUID) to perform in vivo magnetic resonance imaging (MRI) at magnetic fields around 100 microtesla, corresponding to proton Larmor frequencies of about 5 kHz. In such low fields, broadening of the nuclear magnetic resonance lines due to inhomogeneous magnetic fields and susceptibility variations of the sample are minimized, enabling us to obtain high quality images. To reduce environmental noise the signal is detected by a second-order gradiometer, coupled to the SQUID, and the experiment is surrounded by a 3-mm thick Al shield. To increase the signal-to-noise ratio (SNR), we prepolarize the samples in a field up to 100 mT. Three-dimensional images are acquired in less than 6 minutes with a standard spin-echo phase-encoding sequence. Using encoding gradients of /spl sim/100 /spl mu/T/m we obtain three-dimensional images of bell peppers with a resolution of 2/spl times/2/spl times/8 mm/sup 3/. Our system is ideally suited to acquiring images of small, peripheral parts of the human body such as hands and arms. In vivo images of an arm, acquired at 132 /spl mu/T, show 24-mm sections of the forearm with a resolution of 3/spl times/3 mm/sup 2/ and a SNR of 10. We discuss possible applications of MRI at these low magnetic fields.
Speech translation performance of statistical dependency transduction and semantic similarity transduction (2002)

In this paper we compare the performance of two methods for speech translation. One is a statistical dependency transduction model using head transducers, the other a case-based transduction model involving a lexical similarity measure. Examples of translated utterance transcriptions are used in training both models, though the case-based model also uses semantic labels classifying the source utterances. The main conclusion is that while the two methods provide similar translation accuracy under the experimental conditions and accuracy metric used, the statistical dependency transduction method is significantly faster at computing translations.
Tetraethyl 4‐(3‐nitrophenyl)‐2,3,5,6‐pyridinetetracarboxylate (1976)

Abstract Reaction of 3‐nitrobenzaldehyde with diethyl oxalacetate in the presence of piperidine acetate and then ammonium acetate/acetic acid gave a moderate yield of tetraethyl 1,4‐dihydro‐4‐(3‐nitrophenyl)‐2,3,5,6‐pyridinetetracarboxylate. This was oxidized with nitric acid to tetraethyl 4‐(3‐nitrophenyl)‐2,3,5,6‐pyridinetetracarhoxylate which was hydrolyzed and decarboxylated to give 4‐(3‐nitrophenyl)pyridine.
Synthesis of Hexagonal Diamond Polytype in a Thermal Plasma (1994)

Two kinds of diamond film were synthesized on Mo substrates using a plasma jet method, in which methane was injected as a reactant gas into the hydrogen plasma. One (type A) was cubic diamond film with clear habit planes, the other (type B) film with no habit plane. The latter was consisted mainly of a mixture of many kinds of higher hexagonal diamond polytypes, and deposited at a maximum growth rate of 250μm·h-1. These were determined through analyses of X-ray diffraction and selected-area electron diffraction patterns, and scanning electron microscopic observation.In order to find growth conditions for hexagonal diamond polytypes, we also synthesized the diamond film at the different temperature gradients of boundary layer above Mo substrates using an arc plasma reactor. It became clear that the polytypes were synthesized when the temperature gradient was greater than the gradient at which cubic diamond was synthesized.We also studied on the orientation of the hexagonal diamond polytypes deposited on the substrates, and suggested a growth model of the polytypes.
Carbon nanotube based microbolometer development for IR imager and sensor applications (2011)

EO/IR Sensors and imagers using nanostructure based materials are being developed for a variety of Defense
Applications. In this paper, we will discuss recent modeling effort and the experimental work under way for
development of next generation carbon nanostructure based infrared detectors and arrays. We will discuss
detector concepts that will provide next generation high performance, high frame rate, and uncooled nanobolometer
for MWIR and LWIR bands. The critical technologies being developed include carbon
nanostructure growth, characterization, optical and electronic properties that show the feasibility for IR
detection. Experimental results on CNT nanostructures will be presented. We will discuss the path forward to
demonstrate enhanced IR sensitivity and larger arrays.
Notice of Removal: Combination of acoustic radiation force impulse technique and optical coherence tomography to measure elastic properties of the crystalline lens as a function of intraocular pressure (2017)

Removed.
Characterization of the Heparin-binding Site of the Mycobacterial Heparin-binding Hemagglutinin Adhesin (2000)

The mycobacterial adhesin heparin-binding hemagglutinin (HBHA) contains several lysine-rich repeats at its carboxyl-terminal end. Using truncated recombinant HBHA forms and hybrid proteins containing HBHA repeats grafted onto the Escherichia coli maltose-binding protein (MBP), we found that these repeats are responsible for heparin binding. Immunofluorescence microscopy studies revealed that their deletion abrogates binding of HBHA to human pneumocytes. Conversely, when fused to MBP, the HBHA repeats confer pneumocyte adherence properties to the hybrid protein. Treatment of pneumocytes with glycosaminoglycan-degrading enzymes showed that HBHA binding depends on the presence of heparan sulfate chains on the cell surface. The epitope of a monoclonal antibody that inhibits mycobacterial adherence to epithelial cells was mapped within the lysine-rich repeats, confirming their involvement in mycobacterial adherence to epithelial cells. Surface plasmon resonance analyses showed that recombinant HBHA binds to immobilized heparin with fast association kinetics (k(a) = 5.62 (+/- 0.10) x 10(5) m(-1) s(-1)), whereas the dissociation kinetics were slower (k(d) = 0.015 (+/- 0.002) s(-1)), yielding a K(D) value of 26 nm. Similar analyses with grafted MBP indicated similar kinetic constants, indicating that the carboxyl-terminal repeats contain the entire heparin-binding site of HBHA. The molecular characterization of the interactions of HBHA with epithelial glycosaminoglycans should help to better understand mycobacterial adherence within the lungs and may ultimately lead to new approaches for therapy or immunoprophylaxis.
Immunogenicity and Protective Immunity Induced by Synthetic Peptides Associated with Putative Immunodominant Regions of<i>Streptococcus mutans</i>Glucan-Binding Protein B (2003)

Glucan-binding protein B (GbpB) from Streptococcus mutans has been shown to induce protective immunity to dental caries in experimental models. Having recently sequenced the gbpB gene, our objective in this study was to identify immunogenic regions within the GbpB sequence for use in subunit vaccines. Potential regions of immunogenicity were sought by use of a matrix-based algorithm (EpiMatrix) to estimate the binding characteristics of peptides derived from the GbpB sequence by using a database of known major histocompatibility complex class II binding alleles. Screening the entire sequence revealed several peptides with estimated high binding probabilities. Two N-terminal 20-mer peptides (SYI and QGQ) subtending two of these regions were synthesized. A preliminary experiment, in which these peptides were synthesized in the multiple antigenic peptide format and were used to subcutaneously immunize Sprague-Dawley rats twice at a 21-day interval, revealed that the SYI peptide induced a higher percentage of responses to the inciting peptide as well as to intact GbpB, as measured by enzyme-linked immunosorbent assay. The effect of immunization with the SYI peptide construct on the cariogenicity of S. mutans was then investigated by immunizing weanling Sprague-Dawley rats twice at a 9-day interval with SYI or with phosphate-buffered saline. All rats were then orally infected with S. mutans strain SJ. After a 78-day infection period, the SYI-immunized groups had significant reductions in dental caries on both smooth and occlusal surfaces compared with the sham-immunized group. Thus, these experiments indicated that at least one linear sequence, derived from the N-terminal third of GbpB, was sufficiently immunogenic to induce a protective immune response in this experimental rat model for dental caries.
A knowledge-based approach for network radiality in distribution system reconfiguration (2006)

A knowledge-based system is defined that ensures network radiality during reconfiguration of a power distribution system. Network radiality heuristics identify a pair of switching operations that preserves radiality. A matrix-structured knowledge base with five distinct rule bases is used. Rule base A is used in determining which other rule bases to activate. Rule base B is used in considering whether to open a switch and rule base C is used in finding a corresponding initially open switch to close to assume the load transfer that would be necessitated by the switch opening. Rule base D is used in considering whether to close a switch and rule base E is used in finding a corresponding initially closed switch to open because of the load transfer that would be necessitated by the switch closing. In the interest of brevity, only rule bases A, D, and E are described
Evaluation of CO<sub>2</sub>‐based cold sterilization of a model hydrogel (2008)

The purpose of the present work is to evaluate a novel CO(2)-based cold sterilization process in terms of both its killing efficiency and its effects on the physical properties of a model hydrogel, poly(acrylic acid-co-acrylamide) potassium salt. Suspensions of Staphylococcus aureus and Escherichia coli were prepared for hydration and inoculation of the gel. The hydrogels were treated with supercritical CO(2) (40 degrees C, 27.6 MPa). The amount of bacteria was quantified before and after treatment. With pure CO(2), complete killing of S. aureus and E. coli was achieved for treatment times as low as 60 min. After treatment with CO(2) plus trace amounts of H(2)O(2) at the same experimental conditions, complete bacteria kill was also achieved. For times less than 30 min, incomplete kill was noted. Several physical properties of the gel were evaluated before and after SC-CO(2) treatment. These were largely unaffected by the CO(2) process. Drying curves showed no significant change between treated (pure CO(2) and CO(2) plus 30% H(2)O(2)) and untreated samples. The average equilibrium swelling ratios were also very similar. No changes in the dry hydrogel particle structure were evident from SEM micrographs.
A molecular signature of lung cancer: potential biomarkers for adenocarcinoma and squamous cell carcinoma (2017)

Adenocarcinoma (AC) and squamous cell carcinoma (SCC), sub-types of non-small cell lung cancer (NSCLC), both present unique features at the genome, epigenome, transcriptome and proteome levels, as well as shared clinical and histopathological characteristics, but differ in terms of treatment. To ensure proper treatment, one must be able to distinguish between these sub-types. Here, we identify novel biomarker proteins in NSCLC, allowing for distinguishing between the AC and SCC sub-types. Proteomics analysis distinguished between healthy and tumor tissues, with the expression level of 1,494 proteins being altered, 378 of which showed a ≥|100|-fold change. Enrichment of proteins related to protein synthesis and degradation, and of proteins associated with mitochondria, metabolism, and apoptosis, was found. Network analysis defined groups of proteins, such as those associated with cell metabolic processes or with fatty acid/lipid metabolism and transport. Several biomarkers that enable for distinguishing between AC and SCC were identified here for the first time, and together with previous reports confirmed here, led us to propose a list of proteins differentially expressed in SCC and AC. Some of these biomarkers are clear signatures for AC or SCC and four of them are secreted proteins. The presence of the mitochondrial protein SMAC/Diablo in the nucleus was found to be a signature for SCC. Precise diagnosis of AC and SCC is essential for selecting appropriate treatment and thus, increasing patient life expectancy. Finally, the search for drugs that target some of these biomarkers may lead to new treatments for lung cancer.
Practical low-cost high-range-resolution ladar (1995)

This paper treats a practical adaptation of frequency modulation (FM) radar ranging principles to an incoherent laser radar (ladar). In the simplest sense, the ladar's laser transmitter output is amplitude modulated with a radio-frequency subcarrier which itself is linearly frequency modulated. The subcarrier signal may have a start frequency in the tens to low hundreds of megahertz and stop frequency in the hundreds of megahertz to low gigahertz. The difference between the start and stop frequency, (Delta) F, is chosen to establish the desired range resolution,(Delta) R, according to usual equation from FM radar theory, (Delta) R equals c/(2(Delta) F), where c is the velocity of light. The target-reflected light is incoherently detected with a photodiode and converted into a voltage waveform. This waveform is then mixed with an undelayed sample of the original modulation waveform. The output of the mixer is processed to remove `self-clutter' that is commonly generated in FM ranging systems and obscures the true target signals. The clutter-free waveform is then processed coherently using the discrete Fourier transform to recover target amplitude and range. A breadboard of the ladar architecture was developed around a 30-mW GaAlAs diode laser operating at 830 nm. Imagery and range responses obtained show that the theoretical range resolution of 0.25 m was attained for a (Delta) F of 600 MHz. Embodiments of this ladar are likely to be practical and economical for both military and commercial applications because low-cost continuous wave laser diodes are used, coherent optical mixing is not required, and the post- mixing processor bandwidth is low.
High Rejection, 160MHz Bandwidth, High Q-factor 6 GHz RF Filters for Wi-Fi 6E manufactured in a Novel BAW Process (2021)

Wi-Fi 6/6E uses 160 MHz channels in UNII-5/6/7/8 bands in 5-7GHz spectrum for maximizing data rates. A critical challenge for Wi-Fi 6E RF filters is low insertion loss in the 160MHz UNII-5 transmit band while adequately rejecting UNII bands 1, 2C, 3 & 4, which end only 50MHz below the first channel of the UNII-5 band. A 160MHz Wi-Fi 6E bulk acoustic wave (BAW) filter with UNII-5 average pass band insertion loss better than 2dB and 60dB rejection in the UNII-4 band is reported. A unique BAW device fabrication process capable of utilizing a wide variety of piezoelectric thin films is used to manufacture this challenging filter. Fabricated resonators show a maximum quality factor of 2500.
Two-dimensional object-based coding using a content-based mesh and affine motion parameterization (2002)

We present a complete system for 2-D object-based video compression with a method for 2-D content-based triangular mesh design, two connectivity preserving affine motion parameterization schemes, two methods for temporal mesh propagation, a polygon-based adaptive model failure detection/coding scheme, and bit rate control strategies. The feasibility of the proposed methods has been demonstrated by experimental results.
A transponder-shared mesh restoration method for colored, directional ROADM networks (2011)

A method for transponder-shared mesh restoration at the optical layer is presented and evaluated. The total number of backup transponders required for restoration is reduced by considering the typical constraints in colored, directional ROADM networks.
A Time‐Domain Analysis of Intracardiac Electrograms for Arrhythmia Detection (1991)

The analysis of intracardiac electrogram morphology has been proposed as a complementary method for accurate discrimination between sinus rhythm (SR), supraventricular dysrhythmias, and ventricular dysrhythmias by automatic antitachycardia and cardioverter defibrillator devices. In this study, the performance of a traditional time-domain method for surface electrocardiogram interpretation--Correlation Waveform Analysis (CWA) and a newly developed technique--Bin Area Method (BAM) were used to analyze unfiltered intraatrial and intraventricular electrograms obtained from 47 patients during routine cardiac electrophysiology studies. Nineteen patients had 31 distinct, sustained, monomorphic ventricular tachycardias (VTs) induced; 13 patients had paroxysmal bundle branch block of supraventricular origin (BBB) induced; 19 patients had retrograde atrial activation during ventricular overdrive pacing. Three patients were common to two or more groups. Using a best fit electrogram alignment, both CWA and BAM distinguished VT from SR in 28/31 cases (90%), BBB from SR in 15/15 patients (100%), and anterograde from retrograde atrial activation in 19/19 patients (100%). We conclude that the use of time-domain techniques that are independent of amplitude and baseline fluctuations appear to be reliable for discrimination of retrograde atrial activation, paroxysmal BBB, and VT from SR using intracardiac electrograms. Reduction of computational time and power constraints, without sacrificing reliable dysrhythmia discrimination, is possible. These features may make real-time morphology analysis of intracardiac electrograms feasible for automatic antitachycardia and cardioverter-defibrillator devices.
Design and implementation of a passively clamped quasi resonant DC link inverter (2002)

The passively clamped quasi resonant DC link (PCQRL) inverter is a novel soft switched inverter topology proposed to solve two major problems associated with the conventional passively clamped resonant DC link inverter: the high clamp factor problem and the lack of PWM capability. This paper deals with design and control of a three phase PCQRL inverter. Major design issues are discussed. Successful operation of this novel PCQRL inverter based on a prototype design is demonstrated. The results show that this novel converter can reduce the clamp factor from the value of 2.0 p.u. obtained in previous circuits to around 1.25 and add the PWM capabilities to the conventional passive clamp resonant DC link. Several results are presented to illustrate the performance of the proposed inverter topology.