gebhart/patrepeval huggingface dataset:
Rescue therapies for seizure emergencies: New modes of administration (2018)

A subgroup of patients with drug-resistant epilepsy have seizure clusters, which are a part of the continuum of seizure emergencies that includes prolonged episodes and status epilepticus. When the patient or caregiver can identify the beginning of a cluster, the condition is amenable to certain treatments, an approach known as rescue therapy. Intravenous drug administration offers the fastest onset of action, but this route is usually not an option because most seizure clusters occur outside of a medical facility. Alternate routes of administration have been used or are proposed including rectal, buccal, intrapulmonary, subcutaneous, intramuscular, and intranasal. The objective of this narrative review is to describe the (1) anatomical, physiologic, and drug physicochemical properties that need to be considered when developing therapies for seizure emergencies and (2) products currently in development. New therapies must consider parameters of Fick's law such as absorptive surface area, blood flow, membrane thickness, and lipid solubility, because these factors affect both rate and extend of absorption. For example, the lung has a 50 000-fold greater absorptive surface area than that associated with a subcutaneous injection. Lipid solubility is a physicochemical property that influences the absorption rate of small molecule drugs. Among drugs currently used or under development for rescue therapy, allopregnanolone has the greatest lipid solubility at physiologic pH, followed by propofol, midazolam, diazepam, lorazepam, alprazolam, and brivaracetam. However, greater lipid solubility correlates with lower water solubility, complicating formulation of rescue therapies. One approach to overcoming poor aqueous solubility involves the use of a water-soluble prodrug coadministered with a converting enzyme, which is being explored for the intranasal delivery of diazepam. With advances in seizure prediction technology and the development of drug delivery systems that provide rapid onset of effect, rescue therapies may prevent the occurrence of seizures, thus greatly improving the management of epilepsy.
Rotor temperature distribution measuring system (2011)

The work proposes instrumentation for measuring local temperatures on the surface and in the interior of a rotor. The applied design incorporates up to 12 simultaneous local temperature measurements on arbitrary locations in the rotor. Thus, a realistic 3D thermal distribution picture of the rotor can be obtained. The system characterizes with accuracy of α1.5 °C, noise immunity under inverter operation, continuous measuring durations of up to 30h and mechanical rigidity for up to 6000 rpm rotor speed. The mechanical assembly is appropriate for laboratory setups since adaptation on the motor are required. Experimental results, conducted on an induction motor and permanent-magnet synchronous motor, are presented to demonstrate system feasibility.
Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma (2015)

The aberrant processes driving hepatocellular carcinoma (HCC) are not fully understood. Lysophosphatidic acid receptors (LPAR) are commonly overexpressed in HCC, but their contributions to malignant development are not well established. In this report, we show that aberrant expression of LPAR6 sustains tumorigenesis and growth of HCC. Overexpression of LPAR6 in HCC specimens associated with poor survival in a cohort of 128 patients with HCC. We took a genetic approach to elucidate how LPAR6 sustains the HCC tumorigenic process, including through an expression profiling analysis to identify genes under the control of LPAR6. RNAi-mediated attenuation of LPAR6 impaired HCC tumorigenicity in tumor xenograft assays. Expression profiling and mechanistic analyses identified Pim-3 as a pathophysiologically relevant LPAR6 target gene. In nonmalignant cells where LPAR6 overexpression was sufficient to drive malignant character, Pim-3 was upregulated at the level of transcription initiation through a STAT3-dependent mechanism. A further analysis of HCC clinical specimens validated the connection between overexpression of LPAR6 and Pim-3, high proliferation rates, and poorer survival outcomes. Together, our findings establish LPAR6 as an important theranostic target in HCC tumorigenesis.
SOS: Social network-based distributed data storage (2013)

Storing large amounts of data is challenging as it requires large reliable storage space. Currently, peer-to-peer (P2P) systems have been implemented for this purpose. However, these systems provide no guarantee of data retrieval as the data availability is determined by the interest of the users. On the other hand, cloud storage systems, built on top of a pool of powerful servers, can provide reliable data storage; however, they are costly and vulnerable to privacy leakage. This paper proposes a novel distributed data storage system based on the social networks. Particularly, our system utilizes the social information of the users to find the potential storage nodes. The storage nodes are then selected based on the social ties with the data owner. In order to quickly obtain the potential storage nodes, we provide an efficient algorithm to search and compute the social ties in the social networks. The system performance is verified through both theoretical analysis and simulations. The results show that data stored in our proposed system is reliable and stable given the random nature of storage nodes joining and leaving the system. A marginal performance gain is achieved in comparison to P2P systems.
Herpes Simplex Virus Type 1 Regulatory Protein ICP0 Aids Infection in Cells with a Preinduced Interferon Response but Does Not Impede Interferon-Induced Gene Induction (2009)

Several independent lines of evidence indicate that interferon-mediated innate responses are involved in controlling herpes simplex virus type 1 (HSV-1) infection and that the viral immediate-early regulatory protein ICP0 augments HSV-1 replication in interferon-treated cells. However, this is a complex situation in which the experimental outcome is determined by the choice of multiplicity of infection and cell type and by whether cultured cells or animal models are used. It is now known that neither STAT1 nor interferon regulatory factor 3 (IRF-3) play essential roles in the replication defect of ICP0-null mutant HSV-1 in cultured cells. This study set out to investigate the specific role of ICP0 in HSV-1 resistance to the interferon defense. We have used a cell line in which ICP0 expression can be induced at levels similar to those during the early stages of a normal infection to determine whether ICP0 by itself can interfere with interferon or IRF-3-dependent signaling and whether ICP0 enables the virus to circumvent the effects of interferon-stimulated genes (ISGs). We found that the presence of ICP0 was unable to compromise ISG induction by either interferon or double-stranded RNA. On the other hand, ICP0 preexpression reduced but did not eliminate the inhibitory effects of ISGs on HSV-1 infection, with the extent of the relief being highly dependent on multiplicity of infection. The results are discussed in terms of the relationships between ICP0 and intrinsic and innate antiviral resistance mechanisms.
Overexpression of theMET/HGF receptor in ovarian cancer (1994)

The MET oncogene encodes the receptor for Hepatocyte Growth Factor/Scatter Factor, a unique growth factor that induces not only proliferation of epithelial cells, but also cell motility and invasiveness. DNA level and expression of the Met/HGF receptor gene were examined with Southern- and Western-blot analyses, respectively, in human ovary, benign ovarian tumors and epithelial ovarian carcinomas. The Met/HGF receptor was detectable in the surface epithelium of normal ovary. The level of expression was unchanged in benign ovarian tumors of various origins. Fourteen out of 67 malignant carcinomas (20%) showed a 3- to 10-fold increase in expression. In 5 additional cases the Met/HGF protein was overexpressed over 50-fold. This represents a total of 28% of cases. Overexpression was not associated with MET gene amplification. Overexpressing tumors belonged to different histotypic variants, but showed a well-differentiated phenotype. Clinically, overexpression was associated with disease at any pathologic stage, but was significantly correlated with premenopausal status of patients. These data suggest that expression of the Met/HGF receptor may add a selective growth advantage to a narrow subset of differentiated ovarian cancers in premenopausal patients.
Die Göttin der Ekron-Inschrift (2024)

L'article est consacre a l'identification d'une divinite dont le nom (Ptgyh) figure sur une inscription provenant du site d'Ekron (Tel Miqne). L'A. discute les interpretations de ce nom proposees et presente deux autres interpretations supplementaires basees sur d'autres lectures du nom.
Aeff-enlarged Pure-Silica-Core Fiber having Ring-Core Profile (2012)

Pure-silica-core fiber with ring-core profile is designed to have the larger ratio of Aeff to MFD than with step-core, and realized Aeff of 135µm2 and transmission loss of 0.160dB/km with improved splicing loss onto SSMF.
Antimalarial Aminothiazoles and Aminopyridines From Phenotypic Whole-Cell Screening Of A SoftFocus <sup>®</sup> Library (2012)

The current state of antimalarial drug resistance emphasizes the need for new therapies with novel modes of action that will add a significant benefit compared with current standards. In this regard, high throughput phenotypic whole-cell screening aids the discovery of novel antiplasmodial scaffolds that are inherently suited to hit-to-lead and lead-optimization efforts. The aminothiazoles and aminopyridines exemplify two such compound classes stemming from whole-cell screening. Respective structure-activity relationship determinations and subsequent optimization around these scaffolds led to frontrunner compounds in each series, which possess the desired antimalarial efficacy, bioavailability and metabolic stability to further progress medicinal chemistry programs.
Logical timing (global synchronization of asynchronous arrays) (2002)

The problem of global synchronization is solved for asynchronous processor arrays and multiprocessor systems with an arbitrary interconnection graph. Global synchronization of asynchronous systems is treated as a homomorphic mapping of an asynchronous system behavior in logical time onto the behavior of the corresponding synchronous system with a common clock functioning in physical time. The solution is based on decomposing the system to the processor stratum and synchro-stratum; the latter plays the role of a global asynchronous clock. For the case of a synchronous system with two-phase master-slave synchronization, a simple implementation of the synchro-stratum for the corresponding asynchronous system is proposed. It is shown that, depending on the local behavior of the processors, the synchro-stratum is able to perform two types of global synchronization: parallel synchronization and synchronization that uses a system of synchro-waves.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prediction of fire risk based on cloud computing (2020)

The development of cloud computing and big data analysis has given rise to various disaster prediction methods. To reduce the probability of fire accidents, it is critical to predict the fire risk by mining the massive historical data on fire. Considering the advantages of MapReduce, a cloud computing method, in parallel processing of data, this paper puts forward a novel prediction method for fire risk that mines the association rules in the time domain. Firstly, the risk of disaster-causing factors and the ability of disaster-reducing factors were evaluated. Based on the evaluation results, an evaluation index system was constructed for fire risk, and the indices were quantified through proper weighting. Facing the historical fire data, the authors designed the spatiotemporal density-based spatial clustering of applications with noise (spatiotemporal DBSCAN), and quantitatively evaluated fire risk by the association rule mining algorithm based on time domain partition (TDP). The effectiveness of our method in fire risk prediction was verified through experiments. The research results provide reference for the risk prediction of other disasters.
Conducting aluminum‐filled nylon 6 composites (2001)

Abstract This work is concerned with the preparation and characterization of composite materials prepared by compression molding of a mixture of aluminum flakes and nylon 6 powder. The electrical conductivity, density, hardness and morphology of composites were investigated. The electrical conductivity of the composites is < 10 −11 S/cm unless the metal content reached the percolation threshold, beyond which the conductivity increased markedly by as much as 10 11 . The volume fraction of conductive filler at the percolation threshold was calculated from experimental data, by fits to functions predicted by the percolation theory. Decreasing the average particle diameter of filler leads to increased percolation threshold (it varies from 23 to 34 vol% for the three different fillers studied) and decreased maximal conductivity of composites. The density of the composites was measured and compared with values calculated assuming different void levels within the samples. Furthermore, it is shown that for certain sizes of particle filler, the hardness decreases initially with the increase of metal concentration, possibly because of poor surface contact with the nylon matrix, but, starting from a certain value, there is a hardness increase. For the smallest particle filler, the hardness of samples is not influenced by the presence of the filler.
Design of passive vector sum phase shifters (2012)

In this paper, a novel circuit composed of the topology of loaded-line for phase shifter is proposed based on vector sum theory. Compared with the traditional loaded-line phase shifter with only one path from the input port to the output port, the novel design possesses multiple paths. Single-pole single-throw switches (SPSTs) are introduced in each path to alter loaded stubs, resulting in phase shift between different states. As examples, a 3-bit phase shifter is designed and fabricated. The experimental results demonstrate advantages of compact size, low insertion loss, convenient control and easy fabrication.
Chemical composition, antimicrobial and antibiofilm activity of the essential oil and methanol extract of the Mediterranean cypress (Cupressus sempervirens L.) (2014)

The results presented here may suggest that the Eo and extracts of C. sempervirens possess antimicrobial and antibiofilm properties, and therefore, can be used as natural preservative ingredients in food and/or pharmaceuticals.
Nicotinic acetylcholine receptor and superfamily of ligand-gated ion channels (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNicotinic acetylcholine receptor and superfamily of ligand-gated ion channelsRobert M. Stroud, Michael P. McCarthy, and Michael ShusterCite this: Biochemistry 1990, 29, 50, 11009–11023Publication Date (Print):December 18, 1990Publication History Published online1 May 2002Published inissue 18 December 1990https://pubs.acs.org/doi/10.1021/bi00502a001https://doi.org/10.1021/bi00502a001research-articleACS PublicationsRequest reuse permissionsArticle Views428Altmetric-Citations175LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-$Q$ Tunable Microwave Cavity Resonators and Filters Using SOI-Based RF MEMS Tuners (2010)

This paper presents the modeling, design, fabrication, and measurement of microelectromechanical systems-enabled continuously tunable evanescent-mode electromagnetic cavity resonators and filters with very high unloaded quality factors (Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> ). Integrated electrostatically actuated thin diaphragms are used, for the first time, for tuning the frequency of the resonators/filters. An example tunable resonator with 2.6:1 (5.0-1.9 GHz) tuning ratio and Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> of 300-650 is presented. A continuously tunable two-pole filter from 3.04 to 4.71 GHz with 0.7% bandwidth and insertion loss of 3.55-2.38 dB is also shown as a technology demonstrator. Mechanical stability measurements show that the tunable resonators/filters exhibit very low frequency drift (less than 0.5% for 3 h) under constant bias voltage. This paper significantly expands upon previously reported tunable resonators.
<title>Virtual environments for scene of crime reconstruction and analysis</title> (2000)

This paper describes research conducted in collaboration with Greater Manchester Police (UK), to evalute the utility of Virtual Environments for scene of crime analysis, forensic investigation, and law enforcement briefing and training. We present an illustrated case study of the construction of a high-fidelity virtual environment, intended to match a particular real-life crime scene as closely as possible. We describe and evaluate the combination of several approaches including: the use of the Manchester Scene Description Language for constructing complex geometrical models; the application of a radiosity rendering algorithm with several novel features based on human perceptual consideration; texture extraction from forensic photography; and experiments with interactive walkthroughs and large-screen stereoscopic display of the virtual environment implemented using the MAVERIK system. We also discuss the potential applications of Virtual Environment techniques in the Law Enforcement and Forensic communities.
Relativistic Plasma-Wave Excitation by Collinear Optical Mixing (1985)

The relativistic plasma wave excited when the frequency difference between two copropagating C${\mathrm{O}}_{2}$ laser beams equals the plasma frequency is detected for the first time. The plasma-wave frequency, wave number, spatial extent, and saturation time are directly measured by use of 7-mrad, collective, ruby Thomson scattering and the forward-scattered ir spectrum. The wave amplitude $\frac{\stackrel{\ifmmode \tilde{}\else \~{}\fi{}}{n}}{{n}_{0}}$ is inferred to be (1-3)% which gives a longitudinal electric field of 0.3 to 1 GV/m at a laser intensity of 1.7\ifmmode\times\else\texttimes\fi{}${10}^{13}$ W/${\mathrm{cm}}^{2}$, in reasonable agreement with theory.
Pharmacokinetics of low‐dose cidofovir in kidney transplant recipients with BK virus infection (2012)

Cidofovir clearance and eGFR were linearly related irrespective of probenecid administration (r(2) = 0.8 without probenecid; r(2) = 0.7 with probenecid). This relationship allows for the prediction of systemic cidofovir exposure in individual patients and may be utilized to evaluate exposure-response relationships to optimize the cidofovir dosing regimen for BKV infection.
Sequential determination of L-lactate and lactate dehydrogenase with immobilized enzyme electrode (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequential determination of L-lactate and lactate dehydrogenase with immobilized enzyme electrodeFumio. Mizutani, Kanji. Sasaki, and Yukio. ShimuraCite this: Anal. Chem. 1983, 55, 1, 35–38Publication Date (Print):January 1, 1983Publication History Published online1 May 2002Published inissue 1 January 1983https://pubs.acs.org/doi/10.1021/ac00252a012https://doi.org/10.1021/ac00252a012research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supporting Regularized Logistic Regression Privately and Efficiently (2016)

As one of the most popular statistical and machine learning models, logistic regression with regularization has found wide adoption in biomedicine, social sciences, information technology, and so on. These domains often involve data of human subjects that are contingent upon strict privacy regulations. Concerns over data privacy make it increasingly difficult to coordinate and conduct large-scale collaborative studies, which typically rely on cross-institution data sharing and joint analysis. Our work here focuses on safeguarding regularized logistic regression, a widely-used statistical model while at the same time has not been investigated from a data security and privacy perspective. We consider a common use scenario of multi-institution collaborative studies, such as in the form of research consortia or networks as widely seen in genetics, epidemiology, social sciences, etc. To make our privacy-enhancing solution practical, we demonstrate a non-conventional and computationally efficient method leveraging distributing computing and strong cryptography to provide comprehensive protection over individual-level and summary data. Extensive empirical evaluations on several studies validate the privacy guarantee, efficiency and scalability of our proposal. We also discuss the practical implications of our solution for large-scale studies and applications from various disciplines, including genetic and biomedical studies, smart grid, network analysis, etc.