gebhart/patrepeval huggingface dataset:
<i>Listeria monocytogenes</i> mediated CFTR transgene transfer to mammalian cells (2002)

This is the first demonstration of L. monoyctogenes mediated CFTR transgene transfer. The successful in vitro transfer suggests that L. monocytogenes might be a potential vector for cystic fibrosis gene therapy or alternative applications and deserves further investigation in vitro as well as in vivo.
Energy efficient IoT framework for Smart Buildings (2017)

The Internet of Things is a truly state-of-the-art field that has the potential to significantly improve essential services like power saving [8], security, maintenance and monitoring. The implementation of analytics and corrective feedback processes in the event of anomalous data that needs addressing - such as a sharp temperature increase detected by the sensor in a room that is typically maintained at a low temperature, the air-conditioning running for a long time in a room that has no occupant detected, excessive noise detected by a sound sensor - among other things, are some of several ways in which the Internet of Things can be leveraged to help solve fundamental problems in various walks of life. We provide information on setting up and operating a comprehensive apparatus to accomplish these objectives - starting with setting up the desired test bed that has a resilient Data-Flow Path, retrieving the requisite values through the sensors[9], performing analytics on the data using RStudio to gain further insights on the relationship between the various parameters being measured and help set up a predictive model that could draw a contrast between the expected and actual values, thereby suggesting the extent of wastage of resources. Additionally, the GSM module of the Intel Galileo board is also usefully deployed to send out emergency alerts.
Computational Search for Novel Hard Chromium-Based Materials (2017)

Nitrides, carbides, and borides of transition metals are an attractive class of hard materials. Our recent preliminary explorations of the binary chemical compounds indicated that chromium-based materials are among the hardest transition metal compounds. Motivated by this, here we explore in detail the binary Cr-B, Cr-C, and Cr-N systems using global optimization techniques. Calculated enthalpy of formation and hardness of predicted materials were used for Pareto optimization to define the hardest materials with the lowest energy. Our calculations recover all numerous known stable compounds (except Cr<sub>23</sub>C<sub>6</sub> with its large unit cell) and discover a novel stable phase Pmn2<sub>1</sub>-Cr<sub>2</sub>C. We resolve the structure of Cr<sub>2</sub>N and find it to be of anti-CaCl<sub>2</sub> type (space group Pnnm). Many of these phases possess remarkable hardness, but only CrB<sub>4</sub> is superhard (Vickers hardness 48 GPa). Among chromium compounds, borides generally possess the highest hardnesses and greatest stability. Under pressure, we predict stabilization of a layered TMDC-like phase of Cr<sub>2</sub>N, a WC-type phase of CrN, and a new compound CrN<sub>4</sub>. Nitrogen-rich chromium nitride CrN<sub>4</sub> is a high-energy-density material featuring polymeric nitrogen chains. In the presence of metal atoms (e.g., Cr), polymerization of nitrogen takes place at much lower pressures; CrN<sub>4</sub> becomes stable at ∼15 GPa (cf. 110 GPa for synthesis of pure polymeric nitrogen).
Direct minority carrier lifetime measurements and recombination mechanisms in long-wave infrared type II superlattices using time-resolved photoluminescence (2010)

We present a direct optical measurement of minority carrier lifetime as a function of temperature and excitation density in long-wave infrared InAs/GaSb type II superlattices using time-resolved photoluminescence. Results indicate that carrier lifetime is dominated by Shockley–Read–Hall recombination, with a lifetime of 30 ns at 77 K. Below 40 K, we observe a freeze-out of carriers and increased contributions from radiative recombination. High-injection measurements yield a radiative recombination coefficient of 1.8×10−10 cm3/s and an upper limit of the Auger recombination coefficient of 10−28 cm6/s at 60 K. An acceptor level of ∼20 meV above the valence band is also determined.
Dual-Gate Field-Effect Transistor Hydrogen Gas Sensor with Thermal Compensation (2010)

We developed a dual-gate field-effect transistor (FET) hydrogen gas sensor for application to hydrogen vehicles. The dual-gate FET hydrogen sensor was integrated with a Pt-gate FET to detect hydrogen and a Ti-gate FET as the reference sensor in the same Si chip. The Ti-FET had the same structure as the Pt-FET except for the gate metal. The Pt-FET showed a good response to hydrogen gas above 10 ppm in air, while the Ti-FET did not show any response to hydrogen gas. The differential output voltage between the Pt-FET and the Ti-FET was stable in the temperature range from room temperature to 80 °C because of the same temperature dependence of the current–voltage ( I – V ) characteristics. In addition, the temperature of the integrated hydrogen sensor was controlled by an integrated system consisting of a heater and a thermometer at any given temperature under severe weather conditions.
Learning Bidirectional LSTM Networks for Synthesizing 3D Mesh Animation Sequences (2018)

In this paper, we present a novel method for learning to synthesize 3D mesh animation sequences with long short-term memory (LSTM) blocks and mesh-based convolutional neural networks (CNNs). Synthesizing realistic 3D mesh animation sequences is a challenging and important task in computer animation. To achieve this, researchers have long been focusing on shape analysis to develop new interpolation and extrapolation techniques. However, such techniques have limited learning capabilities and therefore can produce unrealistic animation. Deep architectures that operate directly on mesh sequences remain unexplored, due to the following major barriers: meshes with irregular triangles, sequences containing rich temporal information and flexible deformations. To address these, we utilize convolutional neural networks defined on triangular meshes along with a shape deformation representation to extract useful features, followed by LSTM cells that iteratively process the features. To allow completion of a missing mesh sequence from given endpoints, we propose a new weight-shared bidirectional structure. The bidirectional generation loss also helps mitigate error accumulation over iterations. Benefiting from all these technical advances, our approach outperforms existing methods in sequence prediction and completion both qualitatively and quantitatively. Moreover, this network can also generate follow-up frames conditioned on initial shapes and improve the accuracy as more bootstrap models are provided, which other works in the geometry processing domain cannot achieve.
Genome-Scale Probe and Primer Design with PRIMEGENS (2007)

This chapter introduces the software package PRIMEGENS for designing gene-specific probes and associated PCR primers on a large scale. Such design is especially useful for constructing cDNA or oligo microarray to minimize cross-hybridization. PRIMEGENS can also be used for designing primers to amplify a segment of a unique target gene using reverse-transcriptase (RT)-PCR. The input to PRIMEGENS is a set of sequences, whose primers need to be designed, and a sequence pool containing all the genes in a genome. It provides options to choose various parameters. PRIMEGENS uses a systematic algorithm for designing gene-specific probes and its primer pair. For a given sequence, PRIMEGENS first searches for the longest gene-specific fragment and then designs best PCR product for this fragment. The 2.0 version of PRIMEGENS provides a graphical user interface (GUI) with additional features. The software is freely available for any users and can be downloaded from http://digbio.missouri.edu/primegens/.
Extraction of Glycosaminoglycan Peptide from Bovine Nasal Cartilage with 0.1 M Sodium Acetate (1998)

Cartilage is a nonedible byproduct with little saleable value, but it is rich in glycosaminoglycan (GAG), which can be converted to a highly profitable product. In this study, GAG was extracted from bovine cartilaginous tissues including nasal cartilage, occipital articular cartilage, and temporomandibular joint disk without using the expensive exogenous proteinase commonly used to extract GAG from tissues. The GAG was extracted with highest yield ( approximately 80% of total tissue uronic acid) by incubating nasal cartilage in 0.1 M sodium acetate, pH 4.5, at 37 degrees C. Tissue autolysis was suggested to occur under the incubation condition to release GAG-peptide. The GAG-peptide purified by DEAE ion-exchange chromatography contained approximately 7% protein, 89% chondroitin sulfate, and 4% keratan sulfate and had no capability to interact with hyaluronic acid. The results suggest that the extraction method with 0.1 M sodium acetate described in this paper is useful for the preparation of GAG-peptide at a low cost.
Principles of Space-Time Adaptive Processing (2006)

This book presents a systematic introduction to airborne MTI (moving target indication) system design for use in the fields of earth observation, surveillance and reconnaissance, with particular regard to the suppression of clutter returns. New developments in the field and special aspects of airborne MTI radar are included and make this book the definitive text on the principles of STAP.
Electronic and optical switching of solution-phase deposited SnSe2 phase change memory material (2011)

We report the use of chalcogenidometallate clusters as a solution-processable precursor to SnSe2 for phase change memory applications. This precursor is spin-coated onto substrates and then thermally decomposed into a crystalline SnSe2 film. Laser testing of our SnSe2 films indicate very fast recrystallization times of 20 ns. We also fabricate simple planar SnSe2 electronic switching devices that demonstrate switching between ON and OFF resistance states with resistance ratios varying from 7−76. The simple cell design resulted in poor cycling endurance. To demonstrate the precursor’s applicability to advanced via-geometry memory devices, we use the precursor to create void-free SnSe2 structures inside nanowells of ∼25 nm in diameter and ∼40 nm in depth.
A Critical Review of the Last 10 Years of Oleogels in Food (2020)

The field of oleogel research has been active in recent decades, generating numerous oleogels with desirable properties like thermal resistance, texture, and structural stability. Moreover, several food matrices have been formulated with oleogels. In some cases, oleogels in these food products have been shown to resemble textural attributes of products made with conventional hardstock fat, to enhance dietary nutrition, to demonstrate high physical and oxidative stability, and to exhibit a high oil binding capacity. These innovations clearly illustrate the potential of the field of oleogels, but certain drawbacks and a lack of in-depth information in various aspects have delayed its commercialization in the food industry. This review aims to update the current status of the oleogel field and to cover some areas that need to be addressed to make oleogel foods a reality in the near future.
Integrated optical phased array based large angle beam steering system fabricated on silicon-on-insulator (2011)

In this paper, we present a highly compact silicon nano-membrane based optical phased array fabricated using conventional CMOS processing on silicon-on-insulator that provides for over 10 degrees of beam steering in a silicon slab at λ=1.55μm using transverse-electrical polarized light. A low loss 1-to-12 multi-mode interference (MMI) optical beam splitter with high uniformity is used to provide inputs to the optical phased array. Using an unequally spaced waveguide array permits us to relax the half-wavelength spacing requirement for large angle beam steering, thereby avoiding the optical coupling between adjacent waveguides and reducing the side-lobe-level of the array radiation pattern. S-bend waveguides convert the equally spaced MMI output to the unequally spaced wave guide array, while passively equalizing the phases of each array element to compensate for the MMI output phase profile. Independently controllable thin film metal heaters are used to achieve phase shifting using the strong thermo-optic response of silicon. Heat-insulating air grooves minimize thermal crosstalk, while also achieving and low power consumption.
An Innovative and Inexpensive Model for Teaching Cricothyrotomy (2007)

Cricothyrotomy is considered an integral procedure in the practice of emergency medicine. The Accreditation Council for Graduate Medical Education requires residents in emergency medicine to demonstrate proficiency in this skill, but because cricothyrotomy is rarely encountered in the clinical setting, alternative methods to teach this high-stakes procedure become an important curricular component in residency training. We present an innovative and inexpensive method for teaching cricothyrotomy using animal trachea and synthetic skin.
Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions (2010)

We here found, for the first time, the potential role of Sig-1R expression in the heart in attenuating PO-induced hypertrophy in OVX rats. Fluvoxamine treatment protects PO-induced cardiac injury via upregulation of Sig-1R and stimulation of Sig-1R-mediated Akt-eNOS signaling in ovariectomized rats.
ABM Clinical Protocol #26: Persistent Pain with Breastfeeding (2016)

A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient.
Roles of Cysteine Proteases Cwp84 and Cwp13 in Biogenesis of the Cell Wall of Clostridium difficile (2011)

Clostridium difficile expresses a number of cell wall proteins, including the abundant high-molecular-weight and low-molecular-weight S-layer proteins (SLPs). These proteins are generated by posttranslational cleavage of the precursor SlpA by the cysteine protease Cwp84. We compared the phenotypes of C. difficile strains containing insertional mutations in either cwp84 or its paralog cwp13 and complemented with plasmids expressing wild-type or mutant forms of their genes. We show that the presence of uncleaved SlpA in the cell wall of the cwp84 mutant results in aberrant retention of other cell wall proteins at the cell surface, as demonstrated by secretion of the proteins Cwp66 and Cwp2 into the growth medium. These phenotypes are restored by complementation with a plasmid expressing wild-type Cwp84 enzyme but not with one encoding a Cys116Ala substitution in the active site. The cwp13 mutant cleaved the SlpA precursor normally and had a wild-type-like colony phenotype. Both Cwp84 and Cwp13 are produced as proenzymes which are processed by cleavage to produce mature enzymes. In the case of Cwp84, this cleavage does not appear to be autocatalytic, whereas in Cwp13 autocatalysis was demonstrated as a Cys109Ala mutant did not undergo processing. Cwp13 appears to have a role in processing of Cwp84 but is not essential for Cwp84 activity. Cwp13 cleaves SlpA in the HMW SLP domain, which we suggest may reflect a role in cleavage and degradation of misfolded proteins at the cell surface.
Describing best business practices (1999)

To reuse knowledge that has been proven successful in solving problems is an objective which is well worth the effort to investigate in detail. The idea of "patterns" as a method for presenting and using such knowledge is gaining popularity within the Software Engineering community. In the current EU financed research project, ELEKTRA -"Electrical Enterprise Knowledge for Transforming Applications", we are expanding the scope of the "patterns" idea to using it as a way of recording organizational knowledge in the form of "best business practice", in accordance with the objectives of the project. An information system which is currently under construction by a software developer that is a member of the project consortium, including a "patterns-base" will be built. Until now, the partners in the project have mainly been concerned with the presentation and representational issues. These concern how the organizational knowledge will be structured for storage and retrieval purposes. This report presents other issues under discussion such as the nature of the knowledge, its relevance and reusability. As is well known, when developing an information system, it is not the technical details that are of major concern, but rather the social, organizational and communication aspects. It is these, which are the most challenging to deal with that are being addressed, in the current stage of our research.
A fully integrated touch screen controller based on 12b 825kS/s SAR ADC (2009)

This paper describes a low-power 12 bits 825kS/s Successive Approximation Register Analog to Digital Converter (SAR ADC) for personal digital assistants, portable instruments, and touch-screen monitor applications. The proposed SAR ADC is based on 3-stage 4-4-4 C-DAC architecture and a high-speed 3-stages comparator. It features 8 general-purpose input channels and 8 dedicated channels supporting 4, 5, 7, and 8-wire resistive touch-screen panels. It has a full-scale input range, power-down mode for low current consumption, and a novel pen-touch detection control with fast response able to support any touch-screen panel. The ADC performs ±1.3 LSB DNL and ±5 LSB INL when tested up to 125C at supply voltages ranging from 2.7V to 3.6V. Fabricated in a 0.13um CMOS with fringe capacitors, it occupies an area of 0.17 mm2 and has a total dissipation of 200uA at full speed. The circuit has been integrated on Freescale MCF5227x Micro-Controller Unit (MCU) family of devices with a 166 MHz ColdFire(R) core processor and an LCD controller.
Personnel Management in Ireland: A New Epoch? (1996)

This article is based on the case research of eleven Irish manufacturing plants. It assesses the changing role of personnel management and asks whether the strategic role of the function has been enhanced. The change from personnel management to a human resources model, the role, scope and application of the function and its relationship to corporate strategy are explored. The authors conclude that the 'Personnel in crisis' stereotype is not supported by their evidence. On the whole, despite limitations in planning and an integral approach, the personnel function remains in a strong position.
<i>In vivo</i> Off-Resonance Saturation Magnetic Resonance Imaging of αvβ3-Targeted Superparamagnetic Nanoparticles (2009)

Magnetic resonance imaging is a powerful clinical imaging technique that allows for noninvasive tomographic visualization of anatomic structures with high spatial resolution and soft tissue contrast. However, its application in molecular imaging of cancer has been limited by the lack of sensitivity and detection accuracy in depicting the biochemical expression of these diseases. Here, we combine an ultrasensitive design of superparamagnetic polymeric micelles (SPPM) and an off-resonance saturation (ORS) method to enhance the imaging efficacy of tumor biomarkers in vivo. SPPM nanoparticles encoded with cyclic(RGDfK) were able to target the alpha(v)beta(3)-expressing microvasculature in A549 non-small cell lung tumor xenografts in mice. ORS greatly improved tumor detection accuracy over the conventional T(2)*-weighted method by its ability to turn "ON" the contrast of SPPM. This combination of ORS imaging with a tumor vasculature-targeted, ultrasensitive SPPM design offers new opportunities in molecular imaging of cancer.
Isosorbide and 2,5-Furandicarboxylic Acid Based (Co)Polyesters: Synthesis, Characterization, and Environmental Degradation (2022)

Poly(2,5-furandicarboxylate)s incorporating aliphatic moieties represent a promising family of polyesters, typically entirely based on renewable resources and with tailored properties, notably degradability. This study aims to go beyond by developing poly(isosorbide 2,5-furandicarboxylate-<i>co</i>-dodecanedioate) copolyesters derived from isosorbide (Is), 2,5-furandicarboxylic acid (FDCA), and 1,12-dodecanedioic acid (DDA), and studying their degradation under environmental conditions, often overlooked, namely seawater conditions. These novel polyesters have been characterized in-depth using ATR-FTIR, <sup>1</sup>H, and <sup>13</sup>C NMR and XRD spectroscopies and thermal analysis (TGA and DSC). They showed enhanced thermal stability (up to 330 °C), and the glass transition temperature increased with the content of FDCA from ca. 9 to 60 °C. Regarding their (bio)degradation, the enzymatic conditions lead to the highest weight loss compared to simulated seawater conditions, with values matching 27% vs. 3% weight loss after 63 days of incubation, respectively. Copolymerization of biobased FDCA, Is, and DDA represents an optimal approach for shaping the thermal/(bio)degradation behaviors of these novel polyesters.
MicroRNA-10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain-derived neurotrophic factor (2015)

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell Transwell assay data in the article (featured in Figs. 4 and 7) were strikingly similar to data appearing in different form in another article by different authors. Owing to the fact that the contentious data in the above article had already appeared in different form in another article prior to its submission to <i>Molecular Medicine Reports</i>, the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office never received any reply. The Editor apologizes to the readership for any inconvenience caused. [the original article was published in <i>Molecular Medicine Reports</i> 13: 441‑446, 2016; DOI: 10.3892/mmr.2015.4506].
Quantification of multidimensional entanglement stored in a crystal (2017)

The use of multidimensional entanglement opens new perspectives for quantum information processing. However, an important challenge in practice is to certify and characterize multidimensional entanglement from measurement data that are typically limited. Here, we report the certification and quantification of two-photon multidimensional energy-time entanglement between many temporal modes, after one photon has been stored in a crystal. We develop a method for entanglement quantification which makes use of only sparse data obtained with limited resources. This allows us to efficiently certify an entanglement of formation of 1.18 ebits after performing quantum storage. The theoretical methods we develop can be readily extended to a wide range of experimental platforms, while our experimental results demonstrate the suitability of energy-time multidimensional entanglement for a quantum repeater architecture.