gebhart/patrepeval huggingface dataset:
Exploiting Barriers to Optimize Power Consumption of CMPs (2005)

Power consumption is an important concern for future billion transistor designs. This paper proposes a novel technique for optimizing the power consumption of chip-multiprocessors (CMPs) using an integrated hardware-software mechanism. By using a high level synchronization construct, called the barrier, our technique tracks the idle times spent by a processor waiting for other processors to get to the same point in the program. Using this knowledge, the frequency of the processors can be modulated to reduce/eliminate these idle times, thus providing power savings without compromising on performance. Using real applications from the SpecOMP suite, and a complete system CMP simulator, we demonstrate that this approach can provide as much as 40% power savings (and 32% on the average across five applications) with little impact on performance.
Rhenium-Catalyzed Didehydroxylation of Vicinal Diols to Alkenes Using a Simple Alcohol as a Reducing Agent (2010)

A new method for the catalytic didehydroxylation of vicinal diols is described. Employing a readily available low-valent rhenium carbonyl complex and a simple alcohol as a reducing agent, both terminal and internal vicinal diols are deoxygenated to olefins in good yield. The optional addition of acid (TsOH, H(2)SO(4)) provides access to lower reaction temperatures. This new system enables the transformation of a four-carbon sugar polyol into an oxygen-reduced compound, providing promising evidence for its practical application to produce unsaturated compounds from biomass-derived materials.
Effect of growth media on cell envelope composition and nitrile hydratase stability in <i>Rhodococcus rhodochrous</i> strain DAP 96253 (2012)

Rhodococcus is an important industrial microorganism that possesses diverse metabolic capabilities; it also has a cell envelope, composed of an outer layer of mycolic acids and glycolipids. Selected Rhodococcus species when induced are capable of transforming nitriles to the corresponding amide by the enzyme nitrile hydratase (NHase), and subsequently to the corresponding acid via an amidase. This nitrile biochemistry has generated interest in using the rhodococci as biocatalysts. It was hypothesized that altering sugars in the growth medium might impact cell envelope components and have effects on NHase. When the primary carbon source in growth media was changed from glucose to fructose, maltose, or maltodextrin, the NHase activity increased. Cells grown in the presence of maltose and maltodextrin showed the highest activities against propionitrile, 197 and 202 units/mg cdw, respectively. Stability of NHase was also affected as cells grown in the presence of maltose and maltodextrin retained more NHase activity at 55 °C (45 and 23 %, respectively) than cells grown in the presence of glucose or fructose (19 and 10 %, respectively). Supplementation of trehalose in the growth media resulted in increased NHase stability at 55 °C, as cells grown in the presence of glucose retained 40 % NHase activity as opposed to 19 % without the presence of trehalose. Changes in cell envelope components, such mycolic acids and glycolipids, were evaluated by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC), respectively. Changing sugars and the addition of inducing components for NHase, such as cobalt and urea in growth media, resulted in changes in mycolic acid profiles. Mycolic acid content increased 5 times when cobalt and urea were added to media with glucose. Glycolipids levels were also affected by the changes in sugars and addition of inducing components. This research demonstrates that carbohydrate selection impacts NHase activity and stability. Cell envelope components such as mycolic acids are also influenced by sugars and inducers such as cobalt and urea. This is information that can be useful when implementing rhodococcal catalysts in industrial applications.
Neurophysiologic Evaluation of Spastic Hypertonia (2004)

A number of techniques attempt to objectively quantify various clinical characteristics associated with spastic hypertonia and related motor disorders. These range in cost, complexity, physiologic basis of measured response, and invasiveness. With a greater range of treatment options for spasticity and an increase in the number of centers participating in studies of interventions for spasticity, published reports reflect increasing use of objective quantification techniques. We review studies that highlight the potential utility of neurophysiologic techniques, including the H-reflex, F-wave, and flexion withdrawal reflex, in the objective evaluation of response to intrathecal baclofen administration. The accumulated knowledge suggests that neurophysiologic evaluation is useful for assessing spinal cord responsiveness, and we recommend it as an adjunct to clinical evaluation when judging the overall effectiveness of intrathecal baclofen administration.
State and Parameter Estimation of a HEV Li-ion Battery Pack Using Adaptive Kalman Filter with a New SOC-OCV Concept (2009)

A new methodology of defining the relationship between SOC (state of charge) and OCV (open circuit voltage) relationship of the Li-ion battery pack used on HEVs (hybrid electric vehicles) which is independent of the battery condition was proposed. This methodology could avoid the problems resulting from the defects that the conventional SOC-OCV relationship differs between batteries and different working conditions. Based on the new definition, a state and parameter estimator of the Li-ion battery pack based on the Sage-Husa adaptive Kalman filter was proposed. This estimator recruited an equivalent circuit model to describe the dynamic characteristics of the battery pack. The estimator could estimate the SOC, the battery actual capacity and the inner resistance on-board. The implementation of the estimator on a FPGA platform was also introduced. Testing results show that the new definition and the estimator work very well in any specific working condition.
Competitive Mechanisms Subserve Attention in Macaque Areas V2 and V4 (1999)

It is well established that attention modulates visual processing in extrastriate cortex. However, the underlying neural mechanisms are unknown. A consistent observation is that attention has its greatest impact on neuronal responses when multiple stimuli appear together within a cell's receptive field. One way to explain this is to assume that multiple stimuli activate competing populations of neurons and that attention biases this competition in favor of the attended stimulus. In the absence of competing stimuli, there is no competition to be resolved. Accordingly, attention has a more limited effect on the neuronal response to a single stimulus. To test this interpretation, we measured the responses of neurons in macaque areas V2 and V4 using a behavioral paradigm that allowed us to isolate automatic sensory processing mechanisms from attentional effects. First, we measured each cell's response to a single stimulus presented alone inside the receptive field or paired with a second receptive field stimulus, while the monkey attended to a location outside the receptive field. Adding the second stimulus typically caused the neuron's response to move toward the response that was elicited by the second stimulus alone. Then, we directed the monkey's attention to one element of the pair. This drove the neuron's response toward the response elicited when the attended stimulus appeared alone. These findings are consistent with the idea that attention biases competitive interactions among neurons, causing them to respond primarily to the attended stimulus. A quantitative neural model of attention is proposed to account for these results.
Vincristine liposomes with smaller particle size have stronger diffusion ability in tumor and improve tumor accumulation of vincristine significantly (2017)

The passive targeting is the premise of active targeting that could make nanocarrier detained in tumor tissue. The particle size is the most important factor that influences the diffusion and distribution of nanoparticle both <i>in vivo</i> and <i>in vitro</i>. In order to investigate the relationship between particle size and diffusion ability, two kinds of liposome loaded with Vincristine (VCR-Lip) were prepared. The diffusion behavior of VCR-Lip with different particle size and free VCR was compared through diffusion stability study. The diffusion ability from 12-well culture plate to Millipore transwell of each formulation reflected on HepG-2 cytotoxicity results. Different cell placement methods and drug adding positions were used to study the VCR-Lip diffusion behaviors, which influenced the apoptosis of HepG-2 cell. The different cell uptake of Nile red-Lip and free Nile red was compared when changed the adding way of fluorescent fluorescein. To study the penetration ability in HepG-2 tumor spheroids, we constructed 30 nm and 100 nm Cy5.5-Lip to compare with free Cy5.5. Then the anti-tumor effect, tissue distribution of free VCR injection, 30 nm and 100 nm VCR-Lip were further investigated on the HepG-2 tumor bearing nude mice. The results of these study showed that the diffusion ability of free drug and fluorescent fluorescein was remarkable stronger than which encapsulated in liposomes. Moreover, diffusion ability of smaller liposome was stronger than larger one. In this way, 30 nm liposome had not only faster and stronger tumor distribution than 100 nm liposome, but also higher tumor drug accumulation than free drug as well. Our study provided a new thinking to improve the targeting efficiency of nano drug delivery system, no matter passive or active targeting.
Building a Cognitive Application Using Watson DeepQA (2017)

Academic advisors assist students in academic, professional, and personal matters. Successful advising increases applicant yield and student retention, improves graduation rates, and helps students meet educational goals. This work presents a cognitive advising system that answers questions related to a university and its programs. This system uses IBM Watson's cognitive intelligence to identify the question category and then answer the question accordingly. To implement the system, the authors created a four-step systems development process. Their approach will be used as part of a Cognitive Computing in Business course that exposes student teams with diverse skills and backgrounds to both developing and deploying cognitive systems.
Enhancement of the Sagnac effect due to nonlinearly induced nonreciprocity (1981)

We propose a novel way to enhance the Sagnac effect by using a nonlinear ring interferometer. Specifically, we take advantage of the nonlinearly induced nonreciprocity of counterpropagating waves caused by the formation of an index grating in the nonlinear medium.
Reactive Ion-Beam Etching of InP with Cl<sub>2</sub> (1990)

Reactive ion-beam etching (RIBE) of InP with Cl 2 at room temperature has been studied by varying the ion extraction voltage and the gas pressure. The sputtering yield is found to increase linearly with the ion extraction voltage above a threshold voltage. RIBE with a higher Cl 2 gas pressure is dominated by the chemically reactive etching, and offers a higher etch rate and a smoother surface. Smooth surfaces with low concentrations of residual Cl atoms are obtained under the ion extraction voltage of 400 V and Cl 2 gas pressure of 2.5×10 -3 Torr.
Optics in the relativistic regime (2006)

The advent of ultraintense laser pulses generated by the technique of chirped pulse amplification (CPA) along with the development of high-fluence laser materials has opened up an entirely new field of optics. The electromagnetic field intensities produced by these techniques, in excess of ${10}^{18}\phantom{\rule{0.3em}{0ex}}\mathrm{W}∕{\mathrm{cm}}^{2}$, lead to relativistic electron motion in the laser field. The CPA method is reviewed and the future growth of laser technique is discussed, including the prospect of generating the ultimate power of a zettawatt. A number of consequences of relativistic-strength optical fields are surveyed. In contrast to the nonrelativistic regime, these laser fields are capable of moving matter more effectively, including motion in the direction of laser propagation. One of the consequences of this is wakefield generation, a relativistic version of optical rectification, in which longitudinal field effects could be as large as the transverse ones. In addition to this, other effects may occur, including relativistic focusing, relativistic transparency, nonlinear modulation and multiple harmonic generation, and strong coupling to matter and other fields (such as high-frequency radiation). A proper utilization of these phenomena and effects leads to the new technology of relativistic engineering, in which light-matter interactions in the relativistic regime drives the development of laser-driven accelerator science. A number of significant applications are reviewed, including the fast ignition of an inertially confined fusion target by short-pulsed laser energy and potential sources of energetic particles (electrons, protons, other ions, positrons, pions, etc.). The coupling of an intense laser field to matter also has implications for the study of the highest energies in astrophysics, such as ultrahigh-energy cosmic rays, with energies in excess of ${10}^{20}\phantom{\rule{0.3em}{0ex}}\mathrm{eV}$. The laser fields can be so intense as to make the accelerating field large enough for general relativistic effects (via the equivalence principle) to be examined in the laboratory. It will also enable one to access the nonlinear regime of quantum electrodynamics, where the effects of radiative damping are no longer negligible. Furthermore, when the fields are close to the Schwinger value, the vacuum can behave like a nonlinear medium in much the same way as ordinary dielectric matter expanded to laser radiation in the early days of laser research.
The aggregation of mutant p53 produces prion-like properties in cancer (2014)

The tumor suppressor protein p53 loses its function in more than 50% of human malignant tumors. Recent studies have suggested that mutant p53 can form aggregates that are related to loss-of-function effects, negative dominance and gain-of-function effects and cancers with a worsened prognosis. In recent years, several degenerative diseases have been shown to have prion-like properties similar to mammalian prion proteins (PrPs). However, whereas prion diseases are rare, the incidence of these neurodegenerative pathologies is high. Malignant tumors involving mutated forms of the tumor suppressor p53 protein seem to have similar substrata. The aggregation of the entire p53 protein and three functional domains of p53 into amyloid oligomers and fibrils has been demonstrated. Amyloid aggregates of mutant p53 have been detected in breast cancer and malignant skin tumors. Most p53 mutations related to cancer development are found in the DNA-binding domain (p53C), which has been experimentally shown to form amyloid oligomers and fibrils. Several computation programs have corroborated the predicted propensity of p53C to form aggregates, and some of these programs suggest that p53C is more likely to form aggregates than the globular domain of PrP. Overall, studies imply that mutant p53 exerts a dominant-negative regulatory effect on wild-type (WT) p53 and exerts gain-of-function effects when co-aggregating with other proteins such as p63, p73 and acetyltransferase p300. We review here the prion-like behavior of oncogenic p53 mutants that provides an explanation for their dominant-negative and gain-of-function properties and for the high metastatic potential of cancers bearing p53 mutations. The inhibition of the aggregation of p53 into oligomeric and fibrillar amyloids appears to be a promising target for therapeutic intervention in malignant tumor diseases.
Removal of Arsenite from Aqueous Solutions by Anionic Clays (2001)

Layered double hydroxides are antitype 2/1 clay minerals that can be synthesized rapidly under laboratory conditions. Due to their high anion exchange capacities, layered double hydroxides have been investigated as potential adsorbents for removal of anionic contaminants from aqueous systems. In this study, uncalcined and calcined layered double hydroxides were prepared and characterized by X-ray diffraction, with the products evaluated for their ability to adsorb As(III) in aqueous solutions. Results indicated that As(III) could be adsorbed on chloride layered double hydroxide and calcined layered double hydroxide, but no adsorption occurred for carbonate layered double hydroxide. The adsorption isotherms of As(III) on chloride layered double hydroxide and calcined layered double hydroxide were typical L and H-type curves, respectively. The adsorption of As(III) on calcined layered double hydroxide was a slow process and reached a quasi-equilibrium after a 20 hr reaction time. The layered double hydroxides had high pli buffering capacities and the As(III) adsorption on calcined layered double hydroxide was a function of pH. Competing anions strongly affected adsorption, with As(III) adsorption increasing in the order: HPO42- < SO42- < CO32- < F- < Cl- < Br- ≈ I- < NO3-. Adsorbed As(III) on calcined layered double hydroxide could be desorbed by different anions, but there was no systematic relationship between As(III) desorption and anion affinities for the calcined layered double hydroxide. Calcination immobilized the As(III) adsorbed on calcined layered double hydroxides. Although layered double hydroxides could be recycled and used as an adsorbent, its adsorption efficiency was reduced with successive treatments.
A Novel Vehicular Information Network Architecture Based on Named Data Networking (NDN) (2014)

Vehicular information network and Internet of Things (IoT) technologies have been receiving a lot of attention in recent years. As one of the most important and promising IoT areas, a vehicular information network aims to implement a myriad of applications related to vehicles, traffic information, drivers, passengers, and pedestrians. However, intervehicular communication (IVC) in a vehicular information network is still based on the TCP/IP protocol stack which is not efficient and scalable. To address the efficiency and scalability issues of the IVC, we leverage the named data networking (NDN) paradigm where the end user only cares about the needed content and pays no attention to the actual location of the content. The NDN model is highly suitable for the IVC scenario with its hierarchical content naming scheme and flexible content retrieval and caching support. We design a novel vehicular information network architecture based on the basic communication principle of NDN. Our proposed architecture aims to improve content naming, addressing, data aggregation, and mobility for IVC in the vehicular information network. In addition, the key parameter settings of the proposed schemes are analyzed in order to help guide their actual deployment.
Androgen-Independent Molecular Imaging Vectors to Detect Castration-Resistant and Metastatic Prostate Cancer (2011)

Prostate-specific promoters are frequently employed in gene-mediated molecular imaging and therapeutic vectors to diagnose and treat castration-resistant prostate cancer (CRPC) that emerges from hormone ablation therapy. Many of the conventional prostate-specific promoters rely on the androgen axis to drive gene expression. However, considering the cancer heterogeneity and varying androgen receptor status, we herein evaluated the utility of prostate-specific enhancing sequence (PSES), an androgen-independent promoter in CRPC. The PSES is a fused enhancer derived from the prostate-specific antigen (PSA) and prostate-specific membrane antigen gene regulatory region. We augmented the activity of PSES by the two-step transcriptional amplification (TSTA) system to drive the expression of imaging reporter genes for either bioluminescent or positron emission tomography (PET) imaging. The engineered PSES-TSTA system exhibits greatly elevated transcriptional activity, androgen independency, and strong prostate specificity, verified in cell culture and preclinical animal experimentations. These advantageous features of PSES-TSTA elicit superior gene expression capability for CRPC in comparison with the androgen-dependent PSA promoter-driven system. In preclinical settings, we showed robust PET imaging capacity of PSES-TSTA in a castrated prostate xenograft model. Moreover, intravenous administrated PSES-TSTA bioluminescent vector correctly identified tibial bone marrow metastases in 9 of 9 animals, whereas NaF- and FDG-PET was unable to detect the lesions. Taken together, this study showed the promising utility of a potent, androgen-independent, and prostate cancer-specific expression system in directing gene-based molecular imaging in CRPC, even in the context of androgen deprivation therapy.
Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain (2016)

T-type Ca channels (T channels), particularly Cav3.2 among the 3 isoforms, play a role in neuropathic and visceral pain. We thus characterized the effects of RQ-00311651 (RQ), a novel T-channel blocker, in HEK293 cells transfected with human Cav3.1 or Cav3.2 by electrophysiological and fluorescent Ca signaling assays, and also evaluated the antiallodynic/antihyperalgesic activity of RQ in somatic, visceral, and neuropathic pain models in rodents. RQ-00311651 strongly suppressed T currents when tested at holding potentials of -65 ∼ -60 mV, but not -80 mV, in the Cav3.1- or Cav3.2-expressing cells. RQ-00311651 also inhibited high K-induced Ca signaling in those cells. In mice, RQ, administered intraperitoneally (i.p.) at 5 to 20 mg/kg or orally at 20 to 40 mg/kg, significantly suppressed the somatic hyperalgesia and visceral pain-like nociceptive behavior/referred hyperalgesia caused by intraplantar and intracolonic administration of NaHS or Na2S, H2S donors, respectively, which involve the enhanced activity of Cav3.2 channels. RQ-00311651, given i.p. at 5 to 20 mg/kg, exhibited antiallodynic or antihyperalgesic activity in rats with spinal nerve injury-induced neuropathy or in rats and mice with paclitaxel-induced neuropathy. Oral and i.p. RQ at 10 to 20 mg/kg also suppressed the visceral nociceptive behavior and/or referred hyperalgesia accompanying cerulein-induced acute pancreatitis and cyclophosphamide-induced cystitis in mice. The analgesic and antihyperalgesic/antiallodynic doses of oral and i.p. RQ did not significantly affect the locomotor activity and motor coordination. Together, RQ is considered a state-dependent blocker of Cav3.1/Cav3.2 T channels and may serve as an orally available analgesic for treatment of neuropathic and inflammatory pain including distinct visceral pain with minimum central side effects.