gebhart/patrepeval huggingface dataset:
Effect of Various Doses of Recombinant Human Thyrotropin on the Thyroid Radioactive Iodine Uptake and Serum Levels of Thyroid Hormones and Thyroglobulin in Normal Subjects (2001)

Recombinant human TSH (rhTSH), usually given as 0.9-mg doses im on 2 successive days, increases serum thyroglobulin (Tg) and radioactive iodine uptake (RAIU) in residual thyroid tissue in patients with thyroid cancer. We previously reported that a single, relatively low dose of rhTSH (0.1 mg im) is a potent stimulator of T(4), T(3), and Tg secretion in normal subjects. The present study describes the effects of higher doses of rhTSH on thyroid hormone and Tg secretion. Six normal subjects for each dose group, having no evidence of thyroid disease, received either 0.3 or 0.9 mg rhTSH by im injection. Serum TSH, T(4), T(3), and Tg concentrations were measured at 2, 4, and 8 h and 1, 2, 3, 4, and 7 days after rhTSH administration. The peak serum TSH concentrations were 82 +/- 18 and 277 +/- 89 mU/L, respectively, for the 0.3- and 0.9-mg doses of rhTSH. Serum T(4), T(3), and Tg concentrations increased significantly in subjects receiving 0.3 and 0.9 mg rhTSH, with significant increases in T(4) and T(3) being observed before significant increases in serum TG: Peak concentrations of serum T(4), T(3), and Tg, after 0.3 mg rhTSH administration, were 100 +/- 19, 131 +/- 14, and 1035 +/- 724% above individual baselines, respectively. Similarly, peak concentrations of serum T(4), T(3), and Tg, after 0.9 mg rhTSH administration, were 102 +/- 16, 134 +/- 7, and 1890 +/- 768% above individual baselines, respectively. These data, compared with previously reported data for the responses to 0.1 mg rhTSH, indicated that 0.1, 0.3, and 0.9 mg rhTSH had similar quantitative stimulatory effects on thyroid hormone and Tg secretion, except that the T(4) response was greater in groups receiving 0.3 and 0.9 mg rhTSH than in the group receiving 0.1 mg rhTSH. We also studied the effect of rhTSH on the thyroid RAIU in the group that received 0.9 mg rhTSH. The 6- and 24-h RAIU values were significantly higher after rhTSH (pre-rhTSH, 6-h value = 12.5 +/- 1.8%; 24 h value = 23 +/- 2.7%; post-rhTSH, 6 h value = 27 +/- 4.8%; 24-h value = 41 +/- 4.2%). The stimulating effects of 0.9 mg rhTSH on the 6- and 24-h RAIUs were similar. rhTSH is a potent stimulator of T(4), T(3), and Tg secretion and the RAIU in normal subjects. Single doses greater than 0.1--0.3 mg do not seem to further enhance thyroid hormone or Tg secretion.
Antiinflammatory activity ofLonicera japonica (1998)

As part of our investigations into new antiinflammatory agents based on plant extracts, the n-butanol (BuOH) fraction of Lonicera japonica was prepared and its antiinflammatory activity was evaluated using several experimental animal models of inflammation. At oral doses of 100–400 mg/kg, the BuOH fraction showed antiinflammatory activity against acute, granulomatic and chronic inflammation models in mice and rats. Although the activity was not potent compared with prednisolone, the results support the traditional use and suggest that this fraction of L. japonica may yield a safe and mild antiinflammatory agent for treating various inflammatory disorders. © 1998 John Wiley & Sons, Ltd.
Suprious-Free, Near-Zero-TCF Hetero Acoustic Layer (HAL)SAW Resonators Using LiTaO<sub>3</sub> Thin Plate on Quartz (2018)

This paper reports the spurious characteristics of Hetero Acoustic Layer (HAL)SAW resonators at high frequency. Spurious-free characteristic is important for carrier aggregation etc. in addition to high impedance ratio, high Q and small temperature coefficient of frequency (TCF). Four types of LT / quartz HAL SAW resonators were fabricated and evaluated up to 14 GHz. All devices show no significant spurious responses. By contrast, a reference HAL SAW resonator with a structure of LT / SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> / Si shows strong spurious responses near the main response. The spurious responses get closer to the main response using a thinner SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> layer, which is inconvenient for TCF compensation. In addition, the TCF of the HAL SAW resonators are discussed in detail.
Photochemical synthesis of fluorinated graphene via a simultaneous fluorination and reduction route (2013)

We have explored a novel photochemical route to synthesize fluorinated graphene via simultaneously fluorinating and reducing graphene oxide (GO) in HF solution at room temperature. This method avoids special equipment, employs simple UV irradiation and utilizes readily available GO as the carbon source.
Unsteady-State Spherical Flow With Storage and Skin (1985)

Abstract This paper presents short-time interpretation methods for radial-spherical (or radial-hemispherical) flow in homogeneous and isotropic reservoirs inclusive of wellbore storage, wellbore phase redistribution, and damage skin effects. New dimensionless groups are introduced to facilitate the classic transformation from radial flow in the sphere to linear flow in the rod. Analytical expressions, type curves (in log-log and semilog format), and tabulated solutions are presented, both in terms of pressure and rate, for all flow problems considered. A new empirical equation to estimate the duration of wellbore and near-wellbore effects under spherical flow is also proposed.
Role of Nitric Oxide in Immune-Mediated Diseases (1996)

Other| October 01 1996 Role of Nitric Oxide in Immune-Mediated Diseases H. T. Cook; H. T. Cook 1Department of Histopathology, Imperial College School of Medicine at St Mary's, London, U.K. Search for other works by this author on: This Site PubMed Google Scholar V. Cattell V. Cattell 1Department of Histopathology, Imperial College School of Medicine at St Mary's, London, U.K. Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1996) 91 (4): 375–384. https://doi.org/10.1042/cs0910375 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation H. T. Cook, V. Cattell; Role of Nitric Oxide in Immune-Mediated Diseases. Clin Sci (Lond) 1 October 1996; 91 (4): 375–384. doi: https://doi.org/10.1042/cs0910375 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search Keywords: immune complex diseases, immunity, inflammation mediators, nitric oxide, nitric oxide synthase This content is only available as a PDF. © 1996 The Biochemical Society and the Medical Research Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Enamel Carious Lesion Development in Response to Sucrose and Fluoride Concentrations and to Time of Biofilm Formation: An Artificial-Mouth Study (2014)

The aim of this study was to evaluate both sucrose and fluoride concentrations and time of biofilm formation on enamel carious lesions induced by an <i>in vitro</i> artificial-mouth caries model. For Study 1, biofilms formed by streptococci and lactobacilli were grown on the surface of human enamel slabs and exposed to artificial saliva containing 0.50 or 0.75 ppmF (22.5 h/d) and broth containing 3 or 5% sucrose (30 min; 3x/d) over 5 d. In Study 2, biofilms were grown in the presence of 0.75 ppmF and 3% sucrose over 3 and 9 days. Counts of viable cells on biofilms, lesion depth (LD), and the integrated mineral loss (IML) on enamel specimens were assessed at the end of the tested conditions. Counts of total viable cells and <i>L. casei</i> were affected by sucrose and fluoride concentrations as well as by time of biofilm formation. Enamel carious lesions were shallower and IML was lower in the presence of 0.75 ppmF than in the presence of 0.50 ppmF (<i>P</i> < 0.005). No significant effect of sucrose concentrations was found with respect to LD and IML (<i>P</i> > 0.25). Additionally, deeper lesions and higher IML were found after 9 d of biofilm formation (<i>P</i> < 0.005). Distinct sucrose concentrations did not affect enamel carious lesion development. The severity of enamel demineralization was reduced by the presence of the higher fluoride concentration. Additionally, an increase in the time of biofilm formation produced greater demineralization. Our results also suggest that the present model is suitable for studying aspects related to caries lesion development.
OpenCL Programming by Example (2013)

This book follows an example-driven, simplified, and practical approach to using OpenCL for general purpose GPU programming.If you are a beginner in parallel programming and would like to quickly accelerate your algorithms using OpenCL, this book is perfect for you! You will find the diverse topics and case studies in this book interesting and informative. You will only require a good knowledge of C programming for this book, and an understanding of parallel implementations will be useful, but not necessary.
CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia/Reperfusion Injury via Endothelial Nitric Oxide Synthase–Dependent Mechanism (2012)

AMD3100 prolongs BM progenitor mobilization and improves recovery from ischemia/reperfusion injury, and these benefits appear to occur through a previously unidentified link between AMD3100 and BM eNOS expression.
A new technique for preparing monodisperse polymer particles (1992)

Abstract A procedure is described for preparing fairly uniform spheres of three different nylon polymers by phase separation. The mean diameter and polydisperse index were 5 μm and 1.056 for Griltex nylon, 5.7 μm and 1.046 for nylon 6/6, and 12.9 μm and 1.016 for nylon 6. The phase separation is done by taking a 1 wt % solution in a theta solvent above the theta temperature and cooling it rapidly. The spheres of the three nylons have various degrees of roughness. Formation of highly uniform particles during phase separation is discussed in a preliminary way. © 1992 John Wiley & Sons, Inc.
The new spongiosa-hip-joint-endoprosthesis (SHEP). (1993)

The new endoprosthesis system SHEP (Spongiosa Hip Endo-Prosthesis) developed by the author and manufactured by Howmedica has been in clinical use since October 1987. This system comprises a hollow-stem prosthesis with a microporous surface and a straight, collarless stem with circular and oval perforations in the anterior and posterior surfaces. The conical threaded acetabular component is doublewalled. In primary operations endogenous spongiosa is packed into the spaces in the acetabulum and the cavity of the stem, and in exchange procedures the spaces are packed with homologous spongiosa preserved under cold storage. The prosthetic components are implanted cement-free. The system is indicated in all forms of osteoarthritis of the hip. To date more than 360 SHEPs have been implanted by the author and at other clinics, 1/3 of which were exchange prostheses. The biomechanical properties of the prosthesis have undergone endurance tests and far exceed the statutory values. The SHEP system is made of Vitallium, the inlay is polyethylene, and the head is ceramic. Scintiscans initially show raised counting rate quotients compared with the healthy side. Video film reveals impressive bony regeneration and peg-shaped bony bridges between the inner cortical bone and the prosthesis. Microscopic examination shows lamellar bone, rich in osteocytes and osteoblasts. Microscopic investigation of samples from inside the prosthesis (after 5, 9 and 12 months) shows transformation of foreign spongiosa and substitution by endogenous spongiosa or spongy bone with lamellar stratification and good microvascularization.
Heterogeneity in “Homogeneous” Warehouse-Scale Computers: A Performance Opportunity (2011)

The class of modern datacenters recently coined as “warehouse scale computers” (WSCs) has traditionally been embraced as homogeneous computing platforms. However, due to frequent machine replacements and upgrades, modern WSCs are in fact composed of diverse commodity microarchitectures and machine configurations. Yet, current WSCs are designed with an assumption of homogeneity, leaving a potentially significant performance opportunity unexplored. In this paper, we investigate the key factors impacting the available heterogeneity in modern WSCs, and the benefit of exploiting this heterogeneity to maximize overall performance. We also introduce a new metric, opportunity factor, which can be used to quantify an application's sensitivity to the heterogeneity in a given WSC. For applications that are sensitive to heterogeneity, we observe a performance improvement of up to 70% when employing our approach. In a WSC composed of state-of-the-art machines, we can improve the overall performance of the entire datacenter by 16% over the status quo.
Dual-Microphone Speech Dereverberation using a Reference Signal (2007)

Speech signals recorded with a distant microphone usually contain reverberation, which degrades the fidelity and intelligibility of speech, and the recognition performance of automatic speech recognition systems. In this paper we propose a speech dereverberation system which uses two microphones. A generalized sidelobe canceller (GSC) type of structure is used to enhance the desired speech signal. The GSC structure is used to create two signals. The first signal is the output of a standard delay and sum beamformer, and the second signal is a reference signal which is constructed such that the direct speech signal is blocked. We propose to utilize the reverberation which is present in the reference signal to enhance the output of the delay and sum beamformer. The power envelope of the reference signal and the power envelope of the output of the delay and sum beamformer are used to estimate the residual reverberation in the output of the delay and sum beamformer. The output of the delay and sum beamformer is then enhanced using a spectral enhancement technique. The proposed method only requires an estimate of the direction of arrival of the desired speech source. Experiments using simulated room impulse responses are presented and show significant reverberation reduction while keeping the speech distortion low.
Gut microenvironment and immune function (1999)

Overreaction of the acute phase response is responsible for the two major complications to surgery, sepsis and thrombosis, but also most likely for the leading sequela to surgery, adhesion formation. The gastrointestinal tract, especially the colon, is a major player in the acute phase response and responsible for important immune functions with important interactions between the commensal flora, mucosal cells and the mucosa/gut associated lymphoid tissues. These responses can effectively be modulated by enteral nutrition, provided it is properly composed and administered. There is increasing evidence that the important clinical effects sometimes observed in enteral nutrition are more related to immunostimulatory effects than to reduction in microbial translocation. It is suggested that in order to be effective enteral nutrition should be instituted if possible before the operation, but always at least immediately after. Furthermore, much supports that the formula given should contain what has been called colonic food, e.g. plant fibres, and have a low content of saturated fat. Use of antibiotics with deleterious effects on the commensal flora should also be limited as much as possible. Lack of compliance with these requests seems to explain the lack of consistency in clinical experience of enteral nutrition, when tried in connection with trauma and clinical surgery.
Multimodal Markov chain Monte Carlo method for nonlinear petrophysical seismic inversion (2019)

ABSTRACT One of the main objectives in the reservoir characterization is estimating the rock properties based on seismic measurements. We have developed a stochastic sampling method for the joint prediction of facies and petrophysical properties, assuming a nonparametric mixture prior distribution and a nonlinear forward model. The proposed methodology is based on a Markov chain Monte Carlo (MCMC) method specifically designed for multimodal distributions for nonlinear problems. The vector of model parameters includes the facies sequence along the seismic trace as well as the continuous petrophysical properties, such as porosity, mineral fractions, and fluid saturations. At each location, the distribution of petrophysical properties is assumed to be multimodal and nonparametric with as many modes as the number of facies; therefore, along the seismic trace, the distribution is multimodal with the number of modes being equal to the number of facies power the number of samples. Because of the nonlinear forward model, the large number of modes and as a consequence the large dimension of the model space, the analytical computation of the full posterior distribution is not feasible. We then numerically evaluate the posterior distribution by using an MCMC method in which we iteratively sample the facies, by moving from one mode to another, and the petrophysical properties, by sampling within the same mode. The method is extended to multiple seismic traces by applying a first-order Markov chain that accounts for the lateral continuity of the model properties. We first validate the method using a synthetic 2D reservoir model and then we apply the method to a real data set acquired in a carbonate field.
Adhesive Wafer Bonding Using Partially Cured Benzocyclobutene for Three-Dimensional Integration (2006)

Wafer-level three-dimensional integration (3D) is an emerging technology to increase the performance and functionality of integrated circuits (ICs), with adhesive wafer bonding a key step in one of the attractive technology platforms. In such an application, the dielectric adhesive layer needs to be very uniform, and precise wafer-to-wafer alignment accuracy of the bonded wafers is required. In this paper we present a new adhesive wafer bonding process that involves partially curing (cross-linking) of the benzocyclobutene (BCB) coatings prior to bonding. The partially cured BCB layer essentially does not reflow during bonding, minimizing the impact of inhomogeneities in BCB reflow under compression and/or any shear forces at the bonding interface. The resultant nonuniformity of the BCB layer thickness after wafer bonding is less than 1% of the average layer thickness, and the wafers shift relative to each other during the wafer bonding process less than (average) for 200 mm diameter wafers. When bonding two silicon wafers using partially cured BCB, the critical adhesion energy is sufficiently high for subsequent IC processing.
Serum levels of CXCL13 are elevated in active multiple sclerosis (2009)

There is increasing recognition of the important role that B cells play in the pathogenesis of multiple sclerosis (MS). Recently it was reported that the B cell chemokine CXCL13 is elevated in MS serum and cerebrospinal fluid. Here we study whether serum levels of CXCL13 are associated with active MS. We measured serum levels of CXCL13 by enzyme-linked immunosorbent assay in 74 patients with relapsing MS randomized to interferon beta 1b or glatiramer acetate and examined with monthly 3 T brain MRI scans optimized for detection of gadolinium-enhancement for up to 2 years. The median (range) serum levels of CXCL13 pre-treatment were 40 (3-171) pg/ml. Serum levels of CXCL13 were significantly higher at times of active brain MRI scans (p < 0.01). Furthermore, serum levels were higher in patients who never reached MRI remission compared with those in complete (p < 0.01) or partial (p = 0.01) remission. There was a significant positive correlation between the pattern of serum levels of CXCL13 and MRI activity during the first (r = 0.33, p < 0.05) and the full 2 years (r = 0.35, p < 0.01) of the study. Treatment with interferon beta 1b or glatiramer acetate did not affect serum CXCL13. We conclude that the serum levels of the B cell chemokine CXCL13 are associated with active MS.
Oxidation behaviour in air of thin alloy 601 fibres (2000)

The oxidation behaviour in air of 12 mu m diameter continuous alloy 601 fibres has been studied using thermo-gravimetric analysis (TGA) for kinetics identification and transmission electron microscopy (TEM) for determination of the nature of the oxide layers. The TGA allows two stages in the formation of the oxide layer to be distinguished: the first stage corresponds to the growth of a continuous layer of NiO above a discontinuous sub-layer of Cr2O3 whereas the second stage is attributed to the parabolic growth of the Cr2O3 sub-layer, from the time it becomes continuous. A third stage can be observed for high oxidation temperatures. The TEM observations of oxide layers formed after 30 min at 650, 750 and 900 degrees C confirm these results. One common characteristic of these 3 oxidation conditions is the appearance of large cavities under the oxide layer. These cavities seem to be the consequence of the oxidation mechanism of Cr and of the particular morphology of the material (i.e. small diameter cylinders).
Estimation of Middle Distillate Fuel Properties by FT-IR and Chemometrics. Part I. Calibrations and Validations. (1997)

Abstract : As an alternative to established laboratory protocols, an FT-IR method was developed for the rapid, simultaneous determination of several pertinent fuel properties, using less than 2 mL of sample. The method uses a single wavelength range of baseline uncorrected, raw FT-IR spectra. Neither baseline correction nor use of restricted wavelength regions improved the models. Using training sets comprised of over 500 middle distillate fuel samples, models were built to derive pertinent fuel properties from FT-IR spectra. These models showed that a single calibration training set may properly model several properties of fuels collected during different climatic seasons. Cursory experiments suggest that properties of diesel and turbine fuels may be more accurately derived by FT-IR if separate calibration models are used for each class of fuel.
Autophagy: A Druggable Process (2017)

Macroautophagy (hereafter called autophagy) is a vacuolar, lysosomal pathway for catabolism of intracellular material that is conserved among eukaryotic cells. Autophagy plays a crucial role in tissue homeostasis, adaptation to stress situations, immune responses, and the regulation of the inflammatory response. Blockade or uncontrolled activation of autophagy is associated with cancer, diabetes, obesity, cardiovascular disease, neurodegenerative disease, autoimmune disease, infection, and chronic inflammatory disease. During the past decade, researchers have made major progress in understanding the three levels of regulation of autophagy in mammalian cells: signaling, autophagosome formation, and autophagosome maturation and lysosomal degradation. As we discuss in this review, each of these levels is potentially druggable, and, depending on the indication, may be able to stimulate or inhibit autophagy. We also summarize the different modulators of autophagy and their potential and limitations in the treatment of life-threatening diseases.