gebhart/patrepeval huggingface dataset:
Microbial reduction in wastewater treatment using Fe3+ and Al3+ coagulants and PAA disinfectant (2013)

Wastewater is an important source of pathogenic enteric microorganisms in surface water and a major contaminating agent of drinking water. Although primary and secondary wastewater treatments reduce the numbers of microorganisms in wastewater, significant numbers of microbes can still be present in the effluent. The aim of this study was to test the feasibility of tertiary treatment for municipal wastewater treatment plants (WWTPs) using PIX (FeCl3) or PAX (AlCl3) coagulants and peracetic acid (PAA) the disinfectant to reduce microbial load in effluent. Our study showed that both PIX and PAX efficiently reduced microbial numbers. PAA disinfection greatly reduced the numbers of culturable indicator microorganisms (Escherichia coli, intestinal enterococci, F-specific RNA coliphages and somatic DNA coliphages). In addition, pathogenic microorganisms, thermotolerant Campylobacter, Salmonella and norovirus GI, were successfully reduced using the tertiary treatments. In contrast, clostridia, Legionella, rotavirus, norovirus GII and adenovirus showed better resistance against PAA compared to the other microorganisms. However, interpretation of polymerase chain reaction (PCR) analysis results will need further studies to clarify the infectivity of the pathogenic microbes. In conclusion, PIX and PAX flocculants followed by PAA disinfectant can be used as a tertiary treatment for municipal WWTP effluents to reduce the numbers of indicator and pathogenic microorganisms.
IPv6 prefix delegation-based addressing solution for a mobile personal area network (2004)

This paper provides a dynamic IPv6 prefix delegation-based addressing solution to enable Internet connectivity when a Personal Area Network (PAN) is moving between sub-networks. A PAN consists of a cluster of mobile devices, which are dynamically connected with each other and move around together. The approach is based on IPv6 stateless address auto-configuration, and Automatic Prefix Delegation Protocol for IPv6. The problems related to addressing, mobility and IPv6 prefix delegation are evaluated with the constructed prototype. The experiences indicate that the solution is quite light and enables session continuity in subnet changes for any mobile node of a PAN. In addition, the solution does not exclude application of Mobile IPv6 (MIPv6), however Mobile IPv6 is not necessarily needed when Session Initiation Protocol (SIP) based mobility is applied By using SIP, route optimization is also achieved and IPv6 encapsulation is avoided with UDP-based sessions. However, the solution is not necessarily very scalable to big mobile networks.
TP-Space RRT – Kinematic Path Planning of Non-Holonomic Any-Shape Vehicles (2015)

The autonomous navigation of vehicles typically combines two kinds of methods: a path is first planned, and then the robot is driven by a local obstacle-avoidance controller. The present work, which focuses on path planning, proposes an extension to the well-known rapidly-exploring random tree (RRT) algorithm to allow its integration with a trajectory parameter-space (TP-space) as an efficient method to detect collision-free, kinematically-feasible paths for arbitrarily-shaped vehicles. In contrast to original RRT, this proposal generates navigation trees, with poses as nodes, whose edges are all kinematically-feasible paths, suitable to being accurately followed by vehicles driven by pure reactive algorithms. Initial experiments demonstrate the suitability of the method with an Ackermann-steering vehicle model whose severe kinematic constraints cannot be obviated. An important result that sets this work apart from previous research is the finding that employing several families of potential trajectories to expand the tree, which can be done efficiently under the TP-space formalism, improves the optimality of the planned trajectories. A reference C++ implementation has been released as open-source.
Apheresis as novel treatment for refractory angina with raised lipoprotein(a): a randomized controlled cross-over trial (2017)

Lipoprotein apheresis may represent an effective novel treatment for patients with refractory angina and raised lipoprotein(a) improving myocardial perfusion, atheroma burden, exercise capacity and symptoms.
Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening (2000)

Abstract We investigated the efficacies of sirolimus (rapamycin) and cyclosporine for inhibition of graft vascular disease (GVD) in cynomolgus monkey recipients of aortic allografts. Increases in arterial intimal thickening in the midgraft (six consecutive cross-sections) after transplantation were quantified by serial intravascular ultrasound (IVUS) from day 21 to day 105. These data enabled correlations between changes in intimal indexes [II = (intimal area/vessel area) × 100] and trough levels of sirolimus and cyclosporine to be determined. Eighteen recipients received no immunosuppression for 6 weeks to allow alloimmune injury to occur. On day 45, monkeys were treated daily with sirolimus (n = 6) or cyclosporine (n = 6); six monkeys remained untreated. II increased significantly from day 63 to day 105 in untreated monkeys and monkeys treated with cyclosporine, whereas monkeys treated with sirolimus did not have a significant increase in II (P = 0.008, P = 0.006, P = NS; paired t-test). The change in II from days 63 to 105 was significantly greater in untreated monkeys compared to sirolimus-treated monkeys (P = 0.13; one-way ANOVA, P = 0.012 Tukey's post hoc test); other post hoc pairwise comparisons were not significant. Mean sirolimus and cyclosporine levels ± SEM were 43 ± 7 ng/ml and 562 ± 20 ng/ml, respectively. Sirolimus trough levels, but not cyclosporine levels, correlated inversely with changes in II from day 42 to 105 (r2 = 0.73, P = 0.03). This non-human primate study shows that inhibition of intimal thickening by sirolimus depends on trough levels and provides the rationale for clinical trials of sirolimus for the control of GVD in organ transplant recipients.
What Is New HLA-B27 Acute Anterior Uveitis? (2011)

Acute anterior uveitis (AAU) is the most common form of uveitis, accounting for approximately 90% of all cases. Half of all cases of AAU are HLA-B27 positive. The disease is typically acute in onset, unilateral, nongranulomatous inflammation involving the iris and ciliary body, with a tendency to recurrent attacks. Approximately 50% of all patients with HLA-B27 AAU develop an associated seronegative arthritis (SNA), while approximately 25% of the patients initially diagnosed with HLA-B27 SNA develop AAU. Environmental factors play a critical role in the pathogenesis of AAU; in particular, bacterial triggers have been strongly implicated in the development of this disease. Topical corticosteroids and cycloplegic agents remain the cornerstones of treatment for AAU. Salazopirine and methotrexate are effective in decreasing recurrent attacks. Biological agents such as anti-TNF and anti-CD20 therapy may be effective in refractory severe AU but are rarely required.
Temporal changes of lysosome and phagosome pH during phagolysosome formation in macrophages: studies by fluorescence spectroscopy. (1981)

Intravascular pH was measured within the lysosomes and newly formed phagosomes in cultured mouse peritoneal macrophages. The kinetics of pH change in both vacuolar systems was quantitatively determined within a large cell population by fluorescence spectroscopy. Additionally, pH changes within individual phagosomes were followed semiquantitatively using indicator dyes. Two novel findings were made. Firstly, the pH in new phagosomes was transiently driven alkaline (higher than physiological) even when the external medium was buffered at pH 6.5. Secondly, perturbations of phagosome-lysosome fusion had little effect upon phagosomal pH changes, even though the compounds used markedly altered the pH of the lysosomes in resting and phagocytosing cells.
Attribute based shared hidden layers for cross-language knowledge transfer (2016)

Deep neural network (DNN) acoustic models can be adapted to under-resourced languages by transferring the hidden layers. An analogous transfer problem is popular as few-shot learning to recognise scantily seen objects based on their meaningful attributes. In similar way, this paper proposes a principled way to represent the hidden layers of DNN in terms of attributes shared across languages. The diverse phoneme sets of different languages can be represented in terms of phonological features that are shared by them. The DNN layers estimating these features could then be transferred in a meaningful and reliable way. Here, we evaluate model transfer from English to German, by comparing the proposed method with other popular methods on the task of phoneme recognition. Experimental results support that apart from providing interpretability to the DNN acoustic models, the proposed framework provides efficient means for their speedy adaptation to different languages, even in the face of scanty adaptation data.
Potential for Enhancing the Nutritional Properties of Milk Fat (1991)

Milk fat has been identified as a hypercholesterolemic fat because it contains cholesterol and is primarily saturated. However, different types of dietary saturated fats do not have equivalent effects on plasma cholesterol levels relevant to ingestion of polyunsaturated fats. Research suggests that the hypercholesterolemic effect of saturated fats in human diets is largely due to 12, 14, and 16 carbon chain length fatty acids. Evidence also suggests that stearic acid (C18:0) is as effective as oleic acid (C18:ln-9) in lowering plasma cholesterol levels when either replaces palmitic acid (C16:0) in the diet of men. Milk fat has a unique fatty acid profile with approximately 10% short- and medium-chain length saturated fatty acids (less than 12 carbons) and 35% of total fatty acids from stearic and oleic acids. The contribution of milk products to fat and cholesterol intake in the typical American diet is less than that provided by other animal products. This paper will review the recommendations of the National Cholesterol Education Program, the effects of milk fat ingestion on blood cholesterol, and the rationale and feasibility of three approaches to modifying the lipid composition of milk fat.
Visual gene diagnosis of HBV and HCV based on nanoparticle probe amplification and silver staining enhancement (2003)

A visual gene-detecting technique using nanoparticle-supported gene probes is described. With the aid of gold nanoparticle-supported 3'-end-mercapto-derivatized oligonucleotide serving as detection probe, and 5'-end -amino-derivatized oligonucleotide immobilized on glass surface acting as capturing probe, target DNA was detected visually by sandwich hybridization based on highly sensitive "nano-amplification" and silver staining. Different genotypes of Hepatitis B and C viruses in the serum samples from infected patients were detected using home-made HBV, HCV, and HBV/HCV gene chips by the gold/silver nanoparticle staining amplification method. The present visual gene-detecting technique may avoid limitations with the reported methods, for its high sensitivity, good specificity, simplicity, speed, and cheapness. This technique has potential applications in many fields, especially in multi-gene detection gene chips coupled with the detection will find applications in clinic. Additionally, resonance Rayleigh light scattering (RLS) spectroscopy is used, for the first time, to judge and monitor the immobilization of gene probes on gold nanoparticle surfaces.
High speed GaAs integrated circuits (1982)

Much interest has been expressed in the use of GaAs MESFET's for high speed digital integrated circuits (IC's). Propagation delays in the 60- to 90-ps/gate range have been demonstrated by several laboratories on SSI and MSI logic circuits. Recently, large scale digital IC's with over 1000 gates have been demonstrated in GaAs. In this review paper, the device, circuit, and processing approaches presently being explored for high speed GaAs digital circuits are presented. The present performance status of high speed circuits and LSI circuits is reviewed.
Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus (2015)

The forkhead box N1 (Foxn1) protein is the key regulator of thymic epithelial cell (TEC) development, yet how Foxn1 functions remains largely unknown. All mature TECs arise from Foxn1-expressing progenitors/immature TECs and it is widely assumed that TECs as a whole are defined by Foxn1 expression. However, data on the Foxn1 protein are virtually lacking. In this study, we developed novel tools to visualize Foxn1 protein expression at single-cell resolution. We generated Foxn1 knock-in mice expressing a C-terminal hemagglutinin-tagged Foxn1 protein, and a cytometry-grade monoclonal anti-Foxn1 Ab. We evaluated Foxn1 expression patterns in TEC subsets and its dynamics during normal thymus development, aging, injury, and regeneration. Upon challenges, upregulation of Foxn1 was a common feature of thymus regeneration, but the timing of Foxn1 expression changed and the responding TEC subsets depended on the type of treatment. Whereas dexamethasone and recombinant human fibroblast growth factor 7 promoted expansion of Foxn1(+)Ly51(+)CD80(-) TECs, castration led to expansion of Foxn1(+)Ly51(-)CD80(+) TECs. Collectively, Foxn1 expression is highly heterogeneous in the normal thymus, with large fractions of Foxn1(low) or Foxn1(-) TECs accumulating with age. Furthermore, Foxn1 expression is responsive to perturbations.
<i>Closo</i>-Dodecaborate(2-) as a Linker for Iodination of Macromolecules. Aspects on Conjugation Chemistry and Biodistribution (1999)

Boron-containing compounds like closo-dodecaborate(2-) are in theory suitable for radioactive labeling with halogens. The boron-halogen bond is stronger than carbon-halogen bond and is not likely to be recognized by deiodinating enzymes in vivo. Peptides and proteins may be conjugated with various closo-dodecaborate(2-)-containing ligands, and thereafter, the conjugate can be iodinated. Since closo-dodecaborate(2-) is more avidly iodinated than tyrosine in moderately acidic media, such conjugates may be directly labeled on the boron part with radioisotopes of iodine using the standard Chloramine-T procedure. Mercapto-undecahydro-closo-dodecaborate(2-) (BSH) was reacted with the double bond of allyldextran to form a boronated dextran compound of the molecular size of about 70 kDa. This compound, in the text denoted as Dx-BS, and cesium dodecahydro-closo-dodecaborate(2-) were labeled using iodine-125. The two compounds were administered to rats in order to study their in vivo stability. The results indicate that iodinated Dx-BS is stable for about 20 h in vivo. The degradation rate, as indicated by thyroid uptake, was found low. [125I]Iodo-closo-dodecaborate(2-), which is a possible degradation product of [125I]Dx-BS-I, was rapidly excreted in urine without significant accumulation in any organ.
[Dealing with missing, abnormal and incoherent data in E3N cohort study]. (1999)

The main difficulty does not stand so much in the choice and implementation of methods to deal with problematic data than in the identification of their process of existence. Most of what was gained was due to the simplest methods: cold-deck and deductive method.
Host-to-Parasite Gene Transfer in Flowering Plants: Phylogenetic Evidence from Malpighiales (2004)

Horizontal gene transfer (HGT) between sexually unrelated species has recently been documented for higher plants, but mechanistic explanations for HGTs have remained speculative. We show that a parasitic relationship may facilitate HGT between flowering plants. The endophytic parasites Rafflesiaceae are placed in the diverse order Malpighiales. Our multigene phylogenetic analyses of Malpighiales show that mitochondrial (matR) and nuclear loci (18S ribosomal DNA and PHYC) place Rafflesiaceae in Malpighiales, perhaps near Ochnaceae/Clusiaceae. Mitochondrial nad1B-C, however, groups them within Vitaceae, near their obligate host Tetrastigma. These discordant phylogenetic hypotheses strongly suggest that part of the mitochondrial genome in Rafflesiaceae was acquired via HGT from their hosts.
Enhanced ferroelectric properties of Pb(Zr0.53Ti0.47)O3 thin films on SrRuO3/Ru/SiO2/Si substrates (2002)

Highly (110)-oriented Pb(Zr0.53Ti0.47)O3 (PZT) films were deposited on SrRuO3 (SRO)/Ru/SiO2/Si substrates using a sol–gel method, in which SrRuO3 films were deposited at various substrate temperatures. The crystallinity of the PZT films was improved after the annealing process. The leakage current, dielectric constant, and polarization versus electric-field characteristics of PZT films were strongly dependent on the annealing and deposition temperatures of the SRO films. The 650 °C annealed PZT film grown on SRO has a leakage current of 9×10−7 A/cm2 at an applied field of 500 kV/cm, dielectric constant of 1306, remanent polarization (Pr) of 40.1 μC/cm2 and coercive field (Ec) of 78.5 kV/cm at an applied voltage of 5 V. The PZT films indicated fatigue-free characteristics up to ∼1.0×1012 switching cycles under 5 V bipolar pulse.
Methode zur Streubildkontrolle bei Wurfstreuern (2015)

Bei der Ausbringung von Mineraldüngern kommt es maßgeblich auf eine gleichmäßige Verteilung auf der Fläche an. Zur kontrolle des Streubildes - bislang mit aufgestellten Prüfschalen - könnte mit Hilfe der digitalen Bildverarbeitung die Arbeitsqualität bei der Mineraldüngung kontinuierlich und ohne Zeitverzögerung kontrolliert und bei Abweichungen ein Regelsignal ausgegeben werden. Es werden Untersuchungsergebnisse zum Einfluss der Beschaffenheit der Düngerkörner und der Umweltbedingungen auf die Wiederfindungsrate vorgestellt.
White pines,<i>Ribes</i>, and blister rust: a review and synthesis (2010)

Summary For over a century, white pine blister rust ( Cronartium ribicola ) has linked white pines ( Strobus ) with currants and gooseberries ( Ribes ) in a complex and serious disease epidemic in Asia, Europe, and North America. Because of ongoing changes in climate, societal demands for forests and their amenities, and scientific advances in genetics and proteomics, our current understanding and management of the white pine blister rust pathosystem has become outdated. Here, we present a review and synthesis of international scope on the biology and management of blister rust, white pines, Ribes , and other hosts. In this article, we provide a geographical and historical background, describe the taxonomy and life cycle of the rust, discuss pathology and ecology, and introduce a series of invited papers. These review articles summarize the literature on white pines, Ribes , and blister rust with respect to their status, threats, and management through genetics and silviculture. Although the principal focus is on North America, the different epidemics in Europe and Asia are also described. In the final article, we discuss several of the key observations and conclusions from the preceding review articles and identify prudent actions for research and management of white pine blister rust.
Control Strategy for Input-Series–Output-Parallel Converters (2008)

The input-series-output-parallel (ISOP) converter, which consists of multiple dc-dc converter modules connected in series at the input and in parallel at the output, is an attractive solution for high input voltage and high power applications. This paper reveals the relationship between input voltage sharing (IVS) and output current sharing of the constituent modules of the ISOP converter. A novel IVS control strategy, which is decoupled with the output voltage regulation, is proposed. This control allows IVS and output voltage regulation to be designed independently. An ISOP converter, which uses the phase-shifted full-bridge (PS-FB) converter as the basic module, is considered. Based on the proposed control strategy, this ISOP converter together with the control circuit can be decoupled from several independent single-input and single-output systems. An ISOP converter consisting of three PS-FB modules is used to illustrate the design procedure, and a 3-kW experimental prototype is fabricated and tested.
Quantitative estimation of electro-osmosis force on charged particles inside a borosilicate resistive-pulse sensor (2016)

Nano and micron-scale pore sensors have been widely used for biomolecular sensing application due to its sensitive, label-free and potentially cost-effective criteria. Electrophoretic and electroosmosis are major forces which play significant roles on the sensor's performance. In this work, we have developed a mathematical model based on experimental and simulation results of negatively charged particles passing through a 2μm diameter solid-state borosilicate pore under a constant applied electric field. The mathematical model has estimated the ratio of electroosmosis force to electrophoretic force on particles to be 77.5%.
On representing signals using only timing information (2001)

It is well known that only a special class of bandpass signals, called real-zero (RZ) signals can be uniquely represented (up to a scale factor) by their zero crossings, i.e., the time instants at which the signals change their sign. However, it is possible to invertibly map arbitrary bandpass signals into RZ signals, thereby, implicitly represent the bandpass signal using the mapped RZ signal's zero crossings. This mapping is known as real-zero conversion (RZC). In this paper a class of novel signal-adaptive RZC algorithms is proposed. Specifically, algorithms that are analogs of well-known adaptive filtering methods to convert an arbitrary bandpass signal into other signals, whose zero crossings contain sufficient information to represent the bandpass signal's phase and envelope are presented. Since the proposed zero crossings are not those of the original signal, but only indirectly related to it, they are called hidden or covert zero crossings (CoZeCs). The CoZeCs-based representations are developed first for analytic signals, and then extended to real-valued signals. Finally, the proposed algorithms are used to represent synthetic signals and speech signals processed through an analysis filter bank, and it is shown that they can be reconstructed given the CoZeCs. This signal representation has potential in many speech applications.
Theory of passive harmonic mode-locking using waveguide arrays (2008)

A comprehensive theoretical treatment is given of the phenomenon of harmonic mode-locking in a laser cavity mode-locked by the nonlinear mode-coupling behavior in a waveguide array. The theoretical model completely characterizes oscillatory instabilities and the transition from M to M+1 pulses as a function of increased gain.
A new 1 MHz-2 GHz permeance meter for metallic thin films (1997)

We have developed a permeance meter in the 1 MHz-2 GHz range using a shielded loop type pickup coil. The effect of grounding between drive coil and pickup coil was analyzed using time domain reflectometry (TDR). The grounding increased the output voltage and eliminated the multiple reflections in the drive coil. Using the grounding, magnetic thin film permeance can be measured accurately over a wide frequency range. The complex permeance is shown of a l /spl mu/m thick Co/sub 85/Nb/sub 12/Zr/sub 3/ film.