gebhart/patrepeval huggingface dataset:
Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta. (1986)

Cultured human embryonic lung fibroblasts were used as a model to study the effects of transforming growth factor-beta (TGF beta) on the plasminogen activator (PA) activity released by nontumorigenic cells into the culture medium. The cells were exposed to TGF beta under serum-free conditions, and the changes in PA activity and protein metabolism were analyzed by caseinolysis-in-agar assays, zymography, and polypeptide analysis. Treatment of the cells with TGF beta caused a significant decrease in the PA activity of the culture medium as analyzed by the caseinolysis-in-agar assays. The quantitatively most prominent effect of TGF beta on confluent cultures of cells was the induction of an Mr 47,000 protein, as detected by metabolic labeling. The Mr 47,000 protein was a PA inhibitor as judged by reverse zymography. It was antigenically related to a PA inhibitor secreted by HT-1080 tumor cells as demonstrated with monoclonal antibodies. The induced Mr 47,000 inhibitor was deposited into the growth substratum of the cells, as detected by metabolic labeling, immunoblotting analysis, and reverse zymography assays of extracellular matrix preparations. TGF beta also decreased the amounts of urokinase-type and tissue-type PAs accumulated in the conditioned medium, as detected by zymography. Epidermal growth factor antagonized the inhibitory effects of TGF beta by enhancing the amounts of the PAs. These results indicate that growth factors modulate the proteolytic balance of cultured cells by altering the amounts of PAs and their inhibitors.
Optical buffers for variable length packets (2000)

This letter addresses the problem of dimensioning fiber delay lines for optical buffers in a network scenario where packets are asynchronous and of variable length. The focus is placed on providing a simple analytical model to dimension the basic time unit of the fiber delay line, as the crucial parameter that determines the queueing performance.
Improving Label Noise Filtering by Exploiting Unlabeled Data (2018)

With the significant growth in the scale of data, an increasing amount of training data is available in many machine learning tasks. However, it is difficult to ensure perfect labeling with a large volume of training data. Some labels can be incorrect, resulting in label noise, which could lead to deterioration in learning performance. A common way to address label noise is to apply noise filtering techniques to identify and remove noise prior to learning. Multiple noise filtering approaches have been proposed. However, almost all existing works focus on only mislabeled training data and ignore the existence of unlabeled data. In fact, unlabeled data are common in many applications, and their values have been extensively studied and recognized. Therefore, in this paper, we explore the effective use of unlabeled data to improve the noise filtering performance. To this end, we propose a novel noise filtering algorithm called enhanced soft majority voting by exploiting unlabeled data (ESMVU), which is an ensemble-learning-based filter that adopts a soft majority voting strategy. ESMVU provides a systematic way to measure the value of unlabeled data by considering different aspects, such as label confidence and the sample distribution. Finally, the effectiveness of the proposed method is confirmed by experiments and comparison with other methods.
Pemetrexed and Cisplatin for the Treatment of Advanced, Persistent, or Recurrent Carcinoma of the Cervix: A Limited Access Phase II Trial of the Gynecologic Oncology Group (2014)

Pemetrexed in combination with cisplatin demonstrates activity in the treatment of advanced, persistent, or recurrent carcinoma of the cervix.
Mountable eddy current sensor for in-situ remote detection of surface and sub-surface fatigue cracks (2023)

A wireless, integrated, mountable, portable, battery-operated, non-contact eddy current sensor that provides similar accuracy to 1970's laboratory scale equipment (e.g., a Hewlett-Packard GP4194A Impedance Analyzer) at a fraction of the size and cost.
A low-power 1GHz razor FIR accelerator with time-borrow tracking pipeline and approximate error correction in 65nm CMOS (2013)

The unrelenting demands of wireless/multimedia DSP workloads necessitate specialized hardware to achieve higher performance and power efficiency. Razor systems offer even greater power efficiency by minimizing static supply voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> ) guardbands for process/voltage/temperature (PVT) variation, while also providing a degree of resilience to general delay faults (e.g. SEUs). To date, Razor has only been demonstrated on silicon in the context of microprocessor pipelines [1][2]. Reported Algorithmic Noise Tolerance (ANT) circuits [3][4] operate at very high error rates, but rely on imbalanced ripple-carry adders and hence clock frequency (F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">clk</sub> ) is limited (50-88MHz). ANT also requires additional datapaths for error detection/correction, which cannot be clock gated in the absence of errors, increasing baseline area and power. Combining Razor error detection with algorithm-level correction enables high-F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">clk</sub> datapaths and low-overheads. A 0.19mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> 16-tap Razor FIR datapath is fabricated in 65nm LP CMOS, with input and output SRAMs, tunable pulse-clock generator, BIST logic and an AHB slave on-chip bus interface (Fig. 24.5.1), demonstrating: 1) two distinct fixed-latency Razor error-correction techniques for real-time DSP datapaths: time-borrow tracking (TBT) and interpolation-based approximate error correction (AEC); 2) a Razor latch (RZL) circuit with reduced pessimism; 3) a 1GHz datapath, an order of magnitude improvement over [3][4] due to elimination of ripple-carry adders; 4) energy efficiency improvement of up to 37%.
Learning low-rank kernel matrices (2006)

Kernel learning plays an important role in many machine learning tasks. However, algorithms for learning a kernel matrix often scale poorly, with running times that are cubic in the number of data points. In this paper, we propose efficient algorithms for learning low-rank kernel matrices; our algorithms scale linearly in the number of data points and quadratically in the rank of the kernel. We introduce and employ Bregman matrix divergences for rank-deficient matrices---these divergences are natural for our problem since they preserve the rank as well as positive semi-definiteness of the kernel matrix. Special cases of our framework yield faster algorithms for various existing kernel learning problems. Experimental results demonstrate the effectiveness of our algorithms in learning both low-rank and full-rank kernels.
Current-mode electronically-tunable Schmitt Trigger using single 65nm &#x00B1;0.75V CMOS CDTA (2014)

A current-mode electronically-tunable Schmitt Trigger circuit is presented. The analog building block used is a new Multiple-Output CDTA (MO-CDTA) which is designed and implemented at 65 nm CMOS technology node. The proposed circuit employs only a single MO-CDTA and no passive components thereby making it attractive for integration. The operation of the proposed Schmitt Trigger was verified by using SPICE simulations. Electronic tunability of the hysteresis characteristics was also explored with good results. A simple application of the proposed Schmitt Trigger, in the form of a current-mode clock generator is also presented.
Mucosal immunogenicity and adjuvant activity of the recombinant A subunit of the <i>Escherichia coli </i>heat‐labile enterotoxin (1999)

The Escherichia coli heat-labile enterotoxin (LT) is an exceptionally effective mucosal immunogen and mucosal immunoadjuvant towards coadministered antigens. Although, in general, the molecular basis of these properties is poorly understood, both the toxic ADP-ribosylation activity of the LTA subunit and the cellular toxin receptor, ganglioside, GM1-binding properties of the LTB-pentamer have been suggested to be involved. In recent studies we found that GM1-binding is not essential for the adjuvanticity of LT, suggesting an important role for the LTA subunit in immune stimulation. We now describe the immunomodulatory properties of recombinant LTA molecules with or without ADP-ribosylation activity, LTA(His)10 and LTA-E112K(His)10, respectively. These molecules were expressed as fusion proteins with an N-terminal His-tag to allow simple purification on nickel-chelate columns. Their immunogenic and immunoadjuvant properties were assessed upon intranasal administration to mice, and antigen-specific serum immunoglobulin-isotype and -subtype responses and mucosal secretory immunoglobulin A (IgA) responses were monitored using enzyme-linked immunosorbent assay. With respect to immunogenicity, both LTA(His)10 and LTA-E112K(His)10 failed to induce antibody responses. On the other hand, immunization with both LT and the non-toxic LT-E112K mutant not only induced brisk LTB-specific, but also LTA-specific serum and mucosal antibody responses. Therefore, we conclude that linkage of LTA to the LTB pentamer is essential for the induction of LTA-specific responses. With respect to adjuvanticity, both LTA(His)10 and LTA-E112K(His)10 were found to stimulate serum and mucosal antibody responses towards coadministered influenza subunit antigen. Remarkably, responses obtained with LTA(His)10 were comparable in both magnitude and serum immunoglobulin isotype and subtype distributions to those observed after coimmunization with LT, LT-E112K, or recombinant LTB. We conclude that LTA, by itself, can act as a potent adjuvant for intranasally administered antigens in a fashion independent of ADP-ribosylation activity and association with the LTB pentamer.
Experimental and Numerical Evaluation of R<sub>ON</sub>Degradation in GaN HEMTs During Pulse-Mode Operation (2017)

The on-resistance (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> ) degradation in normally-OFF GaN high electron mobility transistors has been evaluated both experimentally and by means of numerical simulations by analyzing its drift during device pulse-mode operation. Experimental data showed that the device RON measured during the on-time interval of the switching period increased with time resulting in a thermally activated process with an activation energy E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">A</sub> = 0.83 eV. For the first time, numerical simulations have been carried out in order to evaluate the device RON drift during pulse-mode operation and to understand the physical phenomena involved. A good qualitative agreement between experimental and simulated data has been obtained when considering in the simulated device simply a hole trap located at 0.83 eV from the GaN valence-band, an energy level which has been linked in previous works to carbon-doping within the GaN buffer.
Proline aminopeptidase activity as a rapid diagnostic test to confirm bacterial vaginosis. (1988)

Two biochemical indicators of bacterial vaginosis, proline aminopeptidase activity and gas-liquid chromatographic analysis, were compared. Five hundred women had their vaginal secretions tested for pH, presence of a positive amine test, levels of volatile and nonvolatile short-chain organic acids, and proline aminopeptidase activity. In addition, direct microscopic and Gram stain examinations were performed. Of the 500 women, 349 (70%) had some form of vaginitis. One hundred sixteen were diagnosed as having bacterial vaginosis, and 69 of these (59%) had Mobiluncus sp on either direct microscopic or Gram stain examination. Two hundred thirty-three had either mixed or other forms of vaginitis. One hundred fifty-one patients were normal. The sensitivity of the proline aminopeptidase assay was 83 and 79%, respectively, in patients having bacterial vaginosis with and without Mobiluncus morphotypes. In contrast, gas-liquid chromatography of short-chain organic acids had sensitivities of 71 and 30%, respectively. Specificity of both assays was about 95%. The greater sensitivity of the proline aminopeptidase assay, especially in patients without Mobiluncus morphotypes, proves its superiority.
Knowledge retrieval and the World Wide Web (2000)

The Web is currently a distributed mass of simple hypertext documents. The authors present a new tool, WebKB that interprets semantic statements stored in Web-accessible documents. WebKB lets its users combine lexical, structural and knowledge-based techniques to exploit or generate Web documents. WebKB is an ontology server and directed Web robot.
15.4: Design of terahertz Extended Interaction Klystrons (2010)

The development of terahertz power amplifiers presents significant new challenges as it brings into focus design, fabrication, and measurement issues that are not important factors at lower frequencies. In this paper, we describe our design approach to meet these challenges with particular emphasis on a 0.67 THz Extended-Interaction Klystron (EIK). This device is being designed to generate a peak power of ~0.5 W with gain of ~23 dB over an instantaneous bandwidth of 15 GHz. The circuit will be driven by a 100 mA, 25 kV electron beam confined in a 0.005"diameter beam tunnel with ~1 Tesla magnetic field. This choice of beam size ensures that the same electron gun can be employed for all program development phases culminating in a 1.03 THz amplifier. A highly efficient depressed collector has also been designed to meet the efficiency requirement.
Usability of Public Administration Electronic Forms (2015)

Tento pĹĂ­spÄvek se zabĂ˝vĂĄ testovĂĄnĂ­m a hodnocenĂ­m formulĂĄĹĹŻ veĹejnĂŠ sprĂĄvy z pohledu jejich pouĹžitelnosti. Jeho cĂ­lem je navrhnout vhodnou metodiku, jak testovat pouĹžitelnost elektronickĂ˝ch formulĂĄĹĹŻ vÄetnÄ jejĂ­ho popisu a tuto metodiku distribuovat odbornĂ­kĹŻm v oblasti informaÄnĂ­ch systĂŠmĹŻ veĹejnĂŠ sprĂĄvy. Nejprve jsou vyjmenovĂĄny metody inĹženĂ˝rstvĂ­ pouĹžitelnosti a vybrĂĄna vhodnĂĄ metoda pro testovĂĄnĂ­ a samotnĂŠ hodnocenĂ­ pouĹžitelnosti elektronickĂ˝ch formulĂĄĹĹŻ. PotĂŠ je navrĹžena metodika testovĂĄnĂ­ pouĹžitelnosti elektronickĂ˝ch formulĂĄĹĹŻ vyuĹžĂ­vajĂ­cĂ­ zvolenou metodu. V poslednĂ­ ÄĂĄsti pĹĂ­spÄvku je navrĹžena a realizovĂĄna pĹĂ­padovĂĄ studie, kterĂĄ vyuĹžĂ­vĂĄ navrĹženou metodiku. HlavnĂ­m pĹĂ­nosem tĂŠto prĂĄce je navrĹženĂ­ metodiky a nĂĄvrh doporuÄenĂ­ pro nĂĄvrh novĂ˝ch elektronickĂ˝ch formulĂĄĹĹŻ veĹejnĂŠ sprĂĄvy.
Evolutionary relationships among group II intron-encoded proteins and identification of a conserved domain that may be related to maturase function (1993)

Many group II introns encode reverse transcriptase-like proteins that potentially function in intron mobility and RNA splicing. We compared 34 intron-encoded open reading frames and four related open reading frames that are not encoded in introns. Many of these open reading frames have a reverse transcriptase-like domain, followed by an additional conserved domain X, and a Zn(2+)-finger-like region. Some open reading frames have lost conserved sequence blocks or key amino acids characteristic of functional reverse transcriptases, and some lack the Zn(2+)-finger-like region. The open reading frames encoded by the chloroplast tRNA(Lys) genes and the related Epifagus virginiana matK open reading frame lack a Zn(2+)-finger-like region and have only remnants of a reverse transcriptase-like domain, but retain a readily identifiable domain X. Several findings lead us to speculate that domain X may function in binding of the intron RNA during reverse transcription and RNA splicing. Overall, our findings are consistent with the hypothesis that all of the known group II intron open reading frames evolved from an ancestral open reading frame, which contained reverse transcriptase, X, and Zn(2+)-finger-like domains, and that the reverse transcriptase and Zn(2+)-finger-like domains were lost in some cases. The retention of domain X in most proteins may reflect an essential function in RNA splicing, which is independent of the reverse transcriptase activity of these proteins.
Imposing Strict Products Liability on Medical Care Providers (1995)

Most jurisdictions preclude strict product liability claims against medical care providers. These jurisdictions have held, generally, that health care professionals do not sell medical products used pursuant to courses of medical treatment as is required under the products liability doctrine generally defined by Restatement (Second) of Torts § 402A and adopted, with modification, a majority of states. However, the Missouri Court of Appeals, in Bell v. Poplar Bluffs Physicians Group, held strict products liability does apply to medical care providers. The purpose of this Note is to analyze the Bell decision in light of both (i) the policies and purposes to be served by strict products liability and (ii) the magnitude of contravening law in Missouri and elsewhere regarding the application of this doctrine to the medical profession.
Consultation section (1992)

Journal of Cataract & Refractive Surgery: March 1992 - Volume 18 - Issue 2 - p 206-214 doi: 10.1016/S0886-3350(13)80938-8
Self-Assembly of Regioregular, Amphiphilic Polythiophenes into Highly Ordered π-Stacked Conjugated Polymer Thin Films and Nanocircuits (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSelf-Assembly of Regioregular, Amphiphilic Polythiophenes into Highly Ordered π-Stacked Conjugated Polymer Thin Films and NanocircuitsThomas Bjørnholm, Daniel R. Greve, Niels Reitzel, Tue Hassenkam, Kristian Kjaer, Paul B. Howes, Niels B. Larsen, Jesper Bøgelund, Manikandan Jayaraman, Paul C. Ewbank, and Richard D. McCulloughView Author Information CISMI, Department of Chemistry, University of Copenhagen Fruebjergvej 3, DK-2100 Copenhagen, Denmark Physics Department, RISØ National Laboratory DK-4000 Roskilde, Denmark Department of Chemistry, Carnegie Mellon University Pittsburgh, Pennsylvania 15213 Cite this: J. Am. Chem. Soc. 1998, 120, 30, 7643–7644Publication Date (Web):July 17, 1998Publication History Received31 March 1998Published online17 July 1998Published inissue 1 August 1998https://pubs.acs.org/doi/10.1021/ja981077ehttps://doi.org/10.1021/ja981077erapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1826Altmetric-Citations131LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Monolayers,Organic polymers,Plastics,Polymers,Thin films Get e-Alerts
Generalized Fast-Convolution-Based Filtered-OFDM: Techniques and Application to 5G New Radio (2020)

This article proposes a generalized model and methods for fast-convolution (FC)-based waveform generation and processing with specific applications to fifth generation new radio (5G-NR). Following the progress of 5G-NR standardization in 3rd generation partnership project (3GPP), the main focus is on subband filtered cyclic prefix (CP) orthogonal frequency-division multiplexing (OFDM) processing with specific emphasis on spectrally well localized transmitter processing. Subband filtering is able to suppress the interference leakage between adjacent subbands, thus supporting different numerologies for so-called bandwidth parts as well as asynchronous multiple access. The proposed generalized FC scheme effectively combines overlapped block processing with time- and frequency-domain windowing to provide highly selective subband filtering with very low intrinsic interference level. Jointly optimized multi-window designs with different allocation sizes and design parameters are compared in terms of interference levels and implementation complexity. The proposed methods are shown to clearly outperform the existing state-of-the-art windowing and filtering-based methods.
Poly(<i><i>N</i>,<i>N</i></i>-diallylazacycloalkane)s for Anion-Exchange Membranes Functionalized with <i>N</i>-Spirocyclic Quaternary Ammonium Cations (2017)

The alkaline stability of organic cations tethered to anion-exchange membranes (AEMs) is essential for the long-term performance of alkaline membrane fuel cells and electrolyzers. Here, we have prepared and studied the thermal and alkaline stability of a series of polyelectrolytes functionalized with N-spirocyclic quaternary ammonium (QA) cations. N,N-diallyl azacycloalkane quaternary salts were readily synthesized by diallylation of pyrrolidine, piperidine, azepane, and morpholine, respectively. These monomers were employed in radical-initiated cyclo-polymerizations to obtain the target poly(N,N-diallyl azacycloalkane)s. 1H NMR spectroscopy revealed that the stability of the polyelectrolytes in 2 M KOD/D2O solutions critically depended on the ring size and the absence of additional heteroatoms in the ring. Thus, poly(N,N-diallyl piperidinium) showed the highest alkaline stability, with only minor signs of degradation at 120 °C after 14 days, while the polyelectrolytes based on the morpholine and azepane rings clearly degraded via both Hofmann elimination and ring-opening substitution already at 90 °C. Crosslinked water non-soluble AEMs were prepared by copolymerizing N,N-diallyl piperidinium chloride with methylbenzyldiallyl ammonium groups tethered to poly(phenylene oxide). These transparent and mechanically robust AEMs reached high OH– conductivities, above 0.1 S cm-1 at 80 °C. The present work demonstrate the high alkaline stability of suitably configured N-spirocyclic QA cations, which will open up new prospects for readily accessible high performance polyelectrolytes and membranes.
A new image labeling method based on content-based image retrieval and conditional random field (2009)

This paper presents a new image labeling approach that implicitly incorporates top-down information using content-based image retrieval (CBIR) with conditional random field (CRF) model. To reduce the content ambiguities a small content similar training set for CRF labeling is built using retrieved matches from CBIR. To achieve global consistency of image labeling, a novel CRF probabilistic model with a revised global factor is also presented. The proposed method is devised for large labeled databases by learning the top-down content information with CBIR and integrating CBIR retrieval information with the CRF model. The new image labeling model base on CBIR and CRF is compared with the CRF approach without retrieval and demonstrates promising results for floor labeling with Labelme database.