gebhart/patrepeval huggingface dataset:
A human monoclonal antibody against varicella-zoster virus glycoprotein III (1991)

Hybridomas producing human monoclonal antibodies (HMAbs) against varicella-zoster virus (VZV) were generated by fusing murine myeloma cells with human lymphocytes immunized in vitro. An assay system was developed to select anti-glycoprotein (gp)III HMAbs from the pool of anti-VZV HMAbs. A murine anti-gpIII MAb, 4B7, did not react with a VZV-infected cell homogenate, but did react with a VZV-infected cell monolayer, whereas anti-gpI and anti-gpII MAbs reacted with both antigens. Hybridomas were screened to obtain HMAbs having a reaction profile similar to that of 4B7 and one such clone, V3, stably produces human IgG1 (kappa). HMAb V3 immunoprecipitated a VZV antigen of 115K to 120K, which was not immunoabsorbed by an anti-gpII HMAb, implying that V3 recognizes gpIII. V3 neutralized VZV independently of complement, unlike anti-gpI and anti-gpII HMAbs. All five strains of VZV tested were completely neutralized by V3, and the dose of V3 required to reduce the number of virus plaques by 50% ranged from 0.027 to 0.15 micrograms/ml. V3 was also able to inhibit the spread of virus infection from infected to uninfected cells, whereas anti-gpI and anti-gpII HMAbs could not. In addition, V3 mediated antibody-dependent cellular cytotoxicity but not complement-dependent cytotoxicity of VZV-infected cells. The results suggest that an anti-gpIII HMAb may provide a new means of passive immunoprophylaxis and also help to identify an antigenic epitope appropriate for a subunit vaccine.
Inline tunable etalon filter for optical channel selection in high density wavelength division multiplexed fibre systems (1988)

We report an inline angle-tuned Fabry-Perot etalon for optical channel selection in a high-density wavelength division multiplexed (WDM) direct-detection experiment. Feasibility is demonstrated in experiments with two different etalons: one for 5 distributed feedback (DFB) lasers in the 1550 nm region (1527–1559 nm), each spaced by 8 nm, and the other for 12 lasers (1527–1549nm), each spaced by 2 nm.
Dimmable LED Driver For DC Distributed Lighting System (2020)

This abstract proposes a high brightness, high efficiency, dimmable LED driver based on linear current regulator technology for DC grid distribution systems. The proposed driver has excellent characteristics like the highest lumen per watt, long lifetime, high reliability, compact, low cost, both environmental and user-friendly which makes it suitable for lighting applications. Steady state and small-signal models of the proposed driver are performed which help in minimizing ground current and accurate compensator design, respectively. These two modeling approaches result in the optimization of both the footprint and cost of the driver. The performance of the proposed experimental prototype of the 20W driver is developed to validate the performance at different dimming levels and achieves maximum efficiency of 97%. The applications of the proposed converter are: dimmable home lighting system, advertisement boards and hoardings, industrial lighting systems, road transport indication lamps, indoor and outdoor stadium lighting, automatic street lighting, decorative systems, health appliances and auditoriums and many more.
Oblivious Parallel RAM and Applications (2015)

We initiate the study of cryptography for parallel RAM (PRAM) programs. The PRAM model captures modern multi-core architectures and cluster computing models, where several processors execute in parallel and make accesses to shared memory, and provides the “best of both ” circuit and RAM models, supporting both cheap random access and parallelism. We propose and attain the notion of Oblivious PRAM. We present a compiler taking any PRAM into one whose distribution of memory accesses is statistically independent of the data (with negligible error), while only incurring a polylogarithmic slowdown (in both total and parallel complexity). We discuss applications of such a compiler, building upon recent advances relying on Oblivious (sequential) RAM (Goldreich Ostrovsky JACM’12). In particular, we demonstrate the construction of a garbled PRAM compiler based on an OPRAM compiler and secure identity-based encryption.
Practical application of compressive sensing to ultra-wideband channels (2012)

Compressive sensing (CS) is proposed by many researchers as a solution to the formidable sampling requirements of promising ultra-wideband (UWB) technology. Previous research was evaluated by simulating the IEEE UWB channel model. This study examines the behaviour of compressive sensing for practical UWB signals and proposes approaches to enhance signal reconstruction performance. Four practical dictionaries are proposed to increase the sparsity of the realistic UWB signals. Those dictionaries account for the practical effects of channel-like pulse dispersion and the unavoidable effects of antenna directivity. Both measured data and a more practical directional model are used for evaluation. It is shown that CS based on the new dictionaries is able to reconstruct the practical UWB signals more efficiently with reasonable complexity. Performance improvement of the proposed practical dictionaries in channel estimation for two different receivers is quantified.
Single mode, piezoelectrically tuned, picosecond short-cavity dye laser (1982)

This letter reports a piezoelectric-translator-tuned, short-cavity picosecond dye laser. This laser, pumped by second or third harmonic picosecond pulses from a mode-locked Nd+3: glass laser, has been operated at cavity lengths which allow only a single longitudinal mode within the lasing bandwidth of a typical dye gain curve. By varying the cavity length with the piezoelectric translator, the output wavelength has been continuously tuned. With different mirror sets and dyes, the lasing output can be varied across the visible spectrum. The laser output is characterized by a modewidth of 0.3 nm (multimode) and 1.5 nm (single mode). The energy conversion efficiency was found to be roughly 0.3% for single-mode operation and ≳3% for multimode operation at 600 nm.
New Pyrrolopyrimidin‐6‐yl Benzenesulfonamides: Potent A<sub>2B</sub> Adenosine Receptor Antagonists. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Evaluation of a cytolethal distending toxin (cdt) gene-based species-specific multiplex PCR assay for the identification of Campylobacter strains isolated from diarrheal patients in Japan. (2011)

We have developed a cytolethal distending toxin (cdt) gene-based species-specific multiplex PCR assay for the detection and identification of Campylobacter jejuni, C. coli, and C. fetus. The applicability of this assay was evaluated with 325 Campylobacter strains isolated from diarrheal patients in Japan and the results were compared with those obtained by other genetic methods, including hipO gene detection and 16S rRNA gene sequencing. Of the 325 strains analyzed, 314 and 11 were identified as C. jejuni and C. coli, respectively, by combination of hipO gene detection and 16S rRNA gene sequencing. When the multiplex PCR assay was employed, 309, 310, and 314 strains were identified as C. jejuni on the basis of cdtA, cdtB, and cdtC gene-specific primers, respectively. Similarly, 11, 11, and 10 strains were identified as C. coli on the basis of cdtA, cdtB, and cdtC gene-specific primers, respectively. Sequence analysis of the cdt gene region of 6 strains (5 C. jejuni and 1 C. coli) which did not yield specific PCR products in any of the cdt gene-based multiplex PCR assays revealed deletions or mutations of the cdt genes. Pulsed-field gel electrophoresis indicated that C. jejuni and C. coli strains were genetically diverse. Taken together, these findings suggest that the cdtC gene-based multiplex PCR seems to be a particularly simple and rapid method for differentiating between species of Campylobacter strains, such as C. jejuni and C. coli. However, combination of these multiplex PCR assays will allow more accurate identification.
RNA virus interference via CRISPR/Cas13a system in plants (2018)

Our data indicate that CRISPR/Cas13a can be used for engineering interference against RNA viruses, providing a potential novel mechanism for RNA-guided immunity against RNA viruses and for other RNA manipulations in plants.
The effect of Sn doping on thermoelectric performance of n-type half-Heusler NbCoSb (2017)

Herein, Sn was successfully doped into the Sb site of n-type NbCoSb half-Heusler compounds to tune the carrier concentration, and a maximum ZT value of ∼0.56 was obtained at 973 K for NbCoSb<sub>1-x</sub>Sn<sub>x</sub> with x = 0.2, an increase of ∼40% as compared to that of NbCoSb. This enhancement is mainly attributed to the reduced carrier concentration by Sn doping, leading to a doubled Seebeck coefficient at 300 K. More importantly, the total thermal conductivity was reduced with Sn doping, and the reduction was mainly due to the lowered electron thermal conductivity. The decreased electron thermal conductivity resulted from the reduced carrier concentration and the consequent enhanced carrier degeneracy, contributing to a reduced Lorenz constant. A quantitative description of the electron transport characteristics was performed under a single parabolic band model supposing that the acoustic phonon scattering was dominant in the carrier transport. A high density of the state effective mass, m* ≈ 10 m<sub>e</sub>, and relatively high deformation potential E<sub>def</sub> = 21 eV were found for the solid solutions.
Genetic Algorithm for Innovative Device Designs in High-Efficiency III–V Nitride Light-Emitting Diodes (2012)

Light-emitting diodes are becoming the next-generation light source because of their prominent benefits in energy efficiency, versatility, and benign environmental impact. However, because of the unique polarization effects in III–V nitrides and the high complexity of light-emitting diodes, further breakthroughs towards truly optimized devices are required. Here we introduce the concept of artificial evolution into the device optimization process. Reproduction and selection are accomplished by means of an advanced genetic algorithm and device simulator, respectively. We demonstrate that this approach can lead to new device structures that go beyond conventional approaches. The innovative designs originating from the genetic algorithm and the demonstration of the predicted results by implementing structures suggested by the algorithm establish a new avenue for complex semiconductor device design and optimization.
Bifunctional Peptide Boronate Inhibitors of Thrombin:  Crystallographic Analysis of Inhibition Enhanced by Linkage to an Exosite 1 Binding Peptide (1998)

The affinity of the hirudin49-64 segment for exosite 1 of thrombin has been used previously to enhance the potency of simple competitive inhibitors [DiMaio, J., Gibbs, B., Munn, D., Lefebvre, J. , Ni, F., Konishi, Y. (1990) J. Biol. Chem. 265, 21698-21703., and Maraganore, J. M., Bourdon, P., Jablonski, J., Ramachandran, K. L., and Fenton, J. W., II (1990) Biochemistry 29, 7095-7087.]. Using a similar approach, we have enhanced the activity of two active site directed thrombin inhibitors by attaching this segment via a novel reverse oriented linker to each of two tripeptide boronate inhibitors. At P1, compound 1 contains an arginine-like, isothiouronium, side chain, while compound 2 contains an uncharged, bromopropyl residue. Inhibition of human alpha-thrombin by compound 1 shows slow, tight-binding competitive kinetics (final Ki of 2.2 pM, k1 of 3.51 x 10(7) M-1 s-1, and k-1 of 1.81 x 10(-)4 s-1). The addition of hirugen peptide (20 microM) competes for exosite 1 binding and restores the k1 and k-1 to that of the analogous tripeptide, 0.29 x 10(7) M-1 s-1 and 0.13 x 10(-)4 s-1, respectively. Compound 1 has enhanced specificity for thrombin over trypsin with KiTry/KiThr of approximately 900 compared to the analogous tripeptide, with KiTry/KiThr of approximately 4. Compound 2 acts as a competitive inhibitor (KiThr of 0.6 nM) and is highly selective with no effect on trypsin. Crystallographic analysis of complexes of human alpha-thrombin with compound 1 (1.8 A) and compound 2 (1.85 A) shows a covalent bond between the boron of the inhibitor and Ser195 (bond lengths B-O of 1.55 and 1.61 A, respectively). The isothiouronium group of compound 1 forms bidentate interactions with Asp189. The P2 and P3 residues of the inhibitors form interactions with the S2 and S3 sites of thrombin similar to other D-Phe-Pro based inhibitors [Bode, W., Turk, D., and Karshikov, A. (1992) Protein Sci. 1, 426-471.]. The linker exits the active site cleft of thrombin forming no interactions, while the binding of Hir49-64 segment to exosite 1 is similar to that previously described for hirudin [Rydel, T. J., Tulinsky, A., and Bode, W. (1991) J. Mol. Biol. 221, 583-601.]. Because of the similarity of binding at each of these sites to that of the analogous peptides added alone, this approach may be used to improve the inhibitory activity of all types of active site directed thrombin inhibitors and may also be applicable to the design of inhibitors of other proteases.
Vaccination of Pregnant Ponies Against Equine Rhinopneumonitis (1980)

Bovine herpesvirus 1247 (one dose) was given subcutaneously to five pregnant pony mares between 227 and 319 days of their gestations. There were no adverse clinical reactions, and the virus was not recovered from nasal swabs collected during a 2-week period after vaccination. Four ponies foaled full-term, live, healthy foals. The foal of the fifth mare (No. 1) was found dead, but on the basis of the pathologic and virologic examinations, the virus was not considered to be the cause of the death. At 3 weeks after vaccination, the pregnant pony mares had a 13- to 250-fold increase in serum antibody titer to equine herpesvirus-1. A virulent-virus challenge exposure of all pony mares at 208 days after vaccination resulted in antibody titers greater than those just before this exposure. Virus was recovered from nasal swabs from vaccinated mares only on postexposure day 1, whereas the one control (nonvaccinated) pony shed virus for at least 3 days after challenge exposure. The immunogenic and the nonabortifacient characteristics of the herpesvirus 1247 in pregnant pony mares indicate that it may be useful to vaccinate horses against equine herpesvirus-1.
Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of H7N9 Influenza Viruses (2018)

Both high- and low-pathogenic H7N9 influenza A virus (IAV) infections have been found in human and poultry in China, and most human cases are related to contact with infected poultry. It is necessary to develop a rapid and simple method to detect H7N9 IAV in poultry. In this study, 13 monoclonal antibodies (McAbs) against the H7N9 IAV hemagglutinin were developed, and three critical amino acid epitopes (198, 227, 235) were identified based on the reactivity of these variant and wild-type strains with the McAbs. We developed an immunochromatographic assay for H7N9 AIVs using two McAbs recognizing the epitope position 227 and 235. The assay had good specificity, stability, and sensitivity, with a detection limit of swab and tissue samples of 2.5 log<sub>10</sub>EID<sub>50</sub>/0.1 mL, which is suitable for the analysis of clinical samples. This assay provides an effective method for the rapid detection of H7N9 AIVs in poultry.
Porphyrins Bearing Mono or Tripodal Benzylphosphonic Acid Tethers for Attachment to Oxide Surfaces (2003)

The ability to attach redox-active molecules to oxide surfaces in controlled architectures (distance, orientation, packing density) is essential for the design of a variety of molecular-based information storage devices. We describe the synthesis of a series of redox-active molecules wherein each molecule bears a benzylphosphonic acid tether. The redox-active molecules include zinc porphyrins, a cobalt porphyrin, and a ferrocene-zinc porphyrin. An analogous tripodal tether has been prepared that is based on a tris[4-(dihydroxyphosphorylmethyl)phenyl]-derivatized methane. A zinc porphyrin is linked to the methane vertex by a 1,4-phenylene unit. The tripodal systems are designed to improve monolayer stability and ensure vertical orientation of the redox-active porphyrin on the electroactive surface. For comparison purposes, a zinc porphyrin bearing a hexylphosphonic acid tether also has been prepared. The synthetic approaches for introduction of the phosphonic acid group include derivatization of a bromoalkyl porphyrin or use of a dimethyl or diethyl phosphonate substituted precursor in a porphyrin-forming reaction. The latter approach makes use of dipyrromethane building blocks bearing mono or tripodal dialkyl phosphonate groups. The zinc porphyrin-tripodal compound bearing benzylphosphonic acid legs tethered to a SiO(2) surface (grown on doped Si) was electrically well-behaved and exhibited characteristic porphyrin oxidation/reduction waves. Collectively, a variety of porphyrinic molecules can now be prepared with tethers of different length, composition, and structure (mono or tripodal) for studies of molecular-based information storage on oxide surfaces.
SDNSOC (2019)

The cloud networks managed by SDN can have multi-tier policy and rule conflicts. The application plane can have conflicting user-defined policies, and the infrastructure layer can have OpenFlow rules conflicting with each other. There is no scalable, and, automated programming framework to detect and resolve multi-tier conflicts in SDN-based cloud networks. We present an object-oriented programming framework - SDN Security Operation Center (SDNSOC), which handles policy composition at application plane, flow rule conflict detection and resolution at the control plane. We follow the design principles of object-oriented paradigm such as code-re-utilization, methods abstraction, aggregation for the implementation of SDNSOC on a multi-tenant cloud network. The key benefits obtained using this approach are (i) The network administrator is abstracted from complex-implementation details of SFC. The end-to-end policy composition of different network functions is handled by an object-oriented framework in an automated fashion. We achieve 37% lower latency in SFC composition compared to nearest competitors - SICS and PGA. (ii) Policy conflict detection between the existing traffic rules and incoming traffic is handled by SDNSOC in a scalable manner. The solution scales well on a large cloud network., and 18% faster security policy conflict detection on a cloud network with 100k OpenFlow rules compared to similar works - Brew, and Flowguard.
an OPTICAL PATTERN recognition system for validation & security verification (1994)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text BAHRAM JAVIDI, JOSEPH L. HORNER, and JOHN F. WALKUP, "an OPTICAL PATTERN recognition system for validation & security verification," Optics & Photonics News 5(9), 13-18 (1994) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Direct tunneling leakage current and scalability of alternative gate dielectrics (2002)

We explore the scaling limits of alternative gate dielectrics based on their direct tunneling characteristics and gate leakage requirements for future complementary metal–oxide–semiconductor technology generations. Important material parameters such as the tunneling effective mass are extracted for several promising high-κ gate dielectrics. We also introduce a figure of merit for comparing the relative advantages of gate dielectric candidates. Using an accurate direct tunneling gate current model and specifications from the International Technology Roadmap for Semiconductors, we provide guidelines for the selection of gate dielectrics to satisfy the off-state leakage current requirements of future high-performance and low power technologies.
Waveband routing and merging in hybrid optical networks (2004)

Hybrid hierarchical optical cross-connects leverages the benefits of both all-optical (OOO) and optical-electrical (OEO) switching for a cost-effective solution in future optical networks. The design goal using hybrid cross-connects is to minimize the sum of two cost metrics: OEO switching cost and OOO switching cost. This paper proposes two different waveband merging architectures and minimum cost routing and merging algorithms for offline traffic scenario. The simulation based results show that the proposed algorithms provide higher cost benefit as compared to existing algorithms that do not rely on waveband merging architecture.
Heparin Binding–Epidermal Growth Factor-Like Growth Factor for the Regeneration of Chronic Tympanic Membrane Perforations in Mice (2015)

We aim to explore the role of epidermal growth factor (EGF) ligand shedding in tympanic membrane wound healing and to investigate the translation of its modulation in tissue engineering of chronic tympanic membrane perforations. Chronic suppurative otitis media (CSOM) is an infected chronic tympanic membrane perforation. Up to 200 million suffer from its associated hearing loss and it is the most common cause of pediatric hearing loss in developing countries. There is a need for nonsurgical treatment due to a worldwide lack of resources. In this study, we show that EGF ligand shedding is essential for tympanic membrane healing as it's inhibition, with KB-R7785, leads to chronic perforation in 87.9% (n=58) compared with 0% (n=20) of controls. We then show that heparin binding-EGF-like growth factor (5 μg/mL), which acts to shed EGF ligands, can regenerate chronic perforations in mouse models with 92% (22 of 24) compared with 38% (10 of 26), also with eustachian tube occlusion with 94% (18 of 19) compared with 9% (2 of 23) and with CSOM 100% (16 of 16) compared with 41% (7 of 17). We also show the nonototoxicity of this treatment and its hydrogel delivery vehicle. This provides preliminary data for a clinical trial where it could be delivered by nonspecialist trained healthcare workers and fulfill the clinical need for a nonsurgical treatment for chronic tympanic membrane perforation and CSOM.
Dispersion compensating fibre with a high figure of merit (2005)

A dispersion compensating fibre with very high negative dispersion and low attenuation resulting in a record high figure of merit of 459 ps/(nm dB) has been developed. Due to the curvature of the dispersion a low residual dispersion of /spl plusmn/0.022 ps/(nm km) has been measured in a link with 100 km NZDF.
Error Bounds for FDD Massive MIMO Channel Covariance Conversion with\n Set-Theoretic Methods (2018)

We derive novel bounds for the performance of algorithms that estimate the\ndownlink covariance matrix from the uplink covariance matrix in frequency\ndivision duplex (FDD) massive multiple-input multiple-output (MIMO) systems.\nThe focus is on algorithms that use estimates of the angular power spectrum as\nan intermediate step. Unlike previous results, the proposed bounds follow from\nsimple arguments in possibly infinite dimensional Hilbert spaces, and they do\nnot require strong assumptions on the array geometry or on the propagation\nmodel. Furthermore, they are suitable for the analysis of set-theoretic methods\nthat can efficiently incorporate side information about the angular power\nspectrum. This last feature enables us to derive simple techniques to enhance\nset-theoretic methods without any heuristic arguments. In particular, we show\nthat the performance of a simple algorithm that requires only a simple\nmatrix-vector multiplication cannot be improved significantly in some practical\nscenarios, especially if coarse information about the support of the angular\npower spectrum is available.\n