gebhart/patrepeval huggingface dataset:
Evidence that the branched‐chain α‐keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex (2004)

Severe neurological symptoms, cerebral edema, and atrophy are common features of the inherited metabolic disorder maple syrup urine disease (MSUD). However, the pathomechanisms involved in the neuropathology of this disease are not well established. In this study, we investigated the effects of the branched-chain keto acids (BCKA) alpha-ketoisocaproic (KIC), alpha-ketoisovaleric (KIV), and alpha-keto-beta-methylvaleric (KMV), which accumulate in MSUD, on astrocyte morphology and cytoskeleton reorganization. Cultured astrocytes from cerebral cortex of neonatal rats were exposed to various concentrations of the BCKA and cell morphology was studied. We observed that these cells changed their usual polygonal morphology when exposed to BCKA, leading to the appearance of fusiform or process-bearing cells. Furthermore, longer exposures to the BCKA elicited cell death at all concentrations studied, attaining massive death at the highest concentrations. Immunocytochemistry with anti-actin or anti-GFAP antibodies revealed that the BCKA induced reorganization of actin and GFAP cytoskeleton. In addition, astrocytes treated with lysophosphatidic acid, an upstream activator of the RhoA GTPase pathway, totally prevented the morphological alterations and cytoskeletal reorganization induced by KIV, indicating that this effect could be mediated by the RhoA signaling pathway. Furthermore, the effects of BCKA on astrocyte morphology were prevented by creatine. In addition, creatine kinase activity was inhibited by KIC and KIV; this inhibition was prevented by creatine, indicating that these keto acids compromise brain energy metabolism. Considering that astroglial cells are critical to brain development and functioning, it is conceivable that alterations of the actin network by BCKA may have important implications in astrocytic function and possibly in the pathogenesis of the neurological dysfunction and brain damage of MSUD patients.
Superconductor and magnet levitation devices (2003)

This article reviews levitation devices using superconductors and magnets. Device concepts and their applications such as noncontact bearings, flywheels, and momentum wheels are discussed, following an exposition of the principles behind these devices. The basic magneto–mechanical phenomenon responsible for levitation in these devices is a result of flux pinning inherent in the interaction between a magnet and a type II superconductor, described and explained in this article by comparison with behavior expected of a perfect conductor or a nearly perfect conductor. The perfect conductor model is used to illustrate why there is a difference between the forces observed when the superconductor is cooled after or before the magnet is brought into position. The same model also establishes the principle that a resisting force or torque arises only in response to those motions of the magnet that changes the magnet field at the superconductor. A corollary of the converse, that no drag torque appears when an axisymmetric magnet levitated above a superconductor rotates, is the guiding concept in the design of superconductor magnet levitation bearings, which is the common component in a majority of levitation devices. The perfect conductor model is extended to a nearly perfect conductor to provide a qualitative understanding of the dissipative aspects such as creep and hysteresis in the interaction between magnets and superconductors. What all these entail in terms of forces, torques, and power loss is expounded further in the context of generic cases of a cylindrical permanent magnet levitated above a superconductor and a superconductor rotating in a transverse magnetic field. Then we proceed to compare the pros and cons of levitation bearings based on the first arrangement with conventional mechanical bearings and active magnetic bearings, and discuss how the weak points of the levitation bearing may be partially overcome. In the latter half, we examine designs of devices using superconductor magnet levitation, focusing more on issues specific to the application. We note that applications of superconductor magnet levitation devices tend to be most attractive in situations where energy conservation is critical. The most advanced in development are flywheel kinetic energy storage systems incorporating superconductor magnet bearings. Variations in the designs to enhance the performance in some specific regards are examined case by case. Next we present a reaction wheel for attitude control on small satellites, similar in overall design to the flywheel kinetic energy storage systems, but with subtle differences in details of emphasis, due to the difference in purpose and environment. Finally, we take a brief look at the case of vibration isolation devices as an example of a rectilinear modification of the more familiar rotational bearing applications.
Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole‐Modified Cyclic Tetrapeptides (2009)

Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or 1,5-disubstituted 1,2,3-triazole in place of a backbone amide bond to fix the bond in question in either a trans-like or a cis-like configuration. Thus, the binding affinity of distinct peptide conformations (see picture) could be probed. One analogue proved in some cases to be superior to apicidin as an HDAC inhibitor.
Point of care lung ultrasound is useful when screening for CoVid-19 in Emergency Department patients (2020)

Background CoVid-19 can be a life-threatening lung disease or a trivial upper respiratory infection depending on whether the alveoli are involved. Emergency department (ED) screening in symptomatic patients with normal vital signs is frequently limited to oro-nasopharyngeal swabs. We tested the null hypothesis that patients being screened for CoVid-19 in the ED with normal vital signs and without hypoxia would have a point-of-care lung ultrasound (LUS) consistent with CoVid-19 less than 2% of the time. Methods Subjects Subjects were identified from ED ultrasound logs. Inclusion criteria Age 14 years or older with symptoms prompting ED screening for CoVid-19. Exclusion criteria Known congestive heart failure or other chronic lung condition likely to cause excessive B lines on LUS. Intervention Structured blinded ultrasound review and chart review Analysis We used an exact hypothesis tests for binomial random variables. We also measured LUS diagnostic performance using computed tomography as the gold standard. Results We reviewed 77 charts; 62 met inclusion criteria. Vital signs were normal in 31 patients; 10 (32%) of these patients had LUS consistent with CoVid-19. We rejected the null hypothesis (p-value for bitest <0.001). The treating physicians' interpretation of their own point of care lung ultrasounds had a sensitivity of 100% (95% CI 75%, 100%) and specificity of 80% (95% CI 68%, 89%). Conclusion LUS has a meaningful detection rate for CoVid-19 in symptomatic emergency department patients with normal vital signs. We recommend at least LUS be used in addition to PCR testing when screening symptomatic ED patients for CoVid-19.
Nonviral DNA Vaccination Augments Microglial Phagocytosis of β-Amyloid Deposits as a Major Clearance Pathway in an Alzheimer Disease Mouse Model (2008)

Immunotherapies markedly reduce beta-amyloid (Abeta) burden and reverse behavioral impairment in mouse models of Alzheimer disease. We previously showed that new Abeta DNA vaccines reduced Abeta deposits in Alzheimer disease model mice without detectable side effects. Although they are effective, the mechanisms of Abeta reduction by the DNA vaccines remain to be elucidated. Here, we analyzed vaccinated and control Alzheimer disease model mice from 4 months to 15 months of age to assess which of several proposed mechanisms may underlie the beneficial effects of this vaccination. Immunohistochemical analysis revealed that activated microglial numbers increased significantly in the brains of vaccinated mice after DNA vaccination both around Abeta plaques and in areas remote from them. Microglia in treated mice phagocytosed Abeta debris more frequently than they did in untreated mice. Although microglia had an activated morphological phenotype, they did not produce significant amounts of tumor necrosis factor. Amyloid plaque immunoreactivity and Abeta concentrations in plasma increased slightly in vaccinated mice compared with controls at 9 but not at 15 months of age. Collectively, these data suggest that phagocytosis of Abeta deposits by microglia plays a central role in Abeta reduction after DNA vaccination.
A comparison of heterotopic ossification treatment within the traumatic brain and spinal cord injured population: An evidence based systematic review (2011)

Within the SCI literature, NSAIDs showed the greatest efficacy in the prevention of HO when administered early after a SCI, and biphosphonates were found to be the most effective treatment strategy. In the TBI population, surgical excision was the most effective treatment.
Weight estimation for downlink null steering in a TDD/SDMA system (2002)

In employing an adaptive array for TDD/SDMA at a base station, generally, the array pattern for the downlink is calculated from that for the uplink. Considering the angle spread in a Rayleigh fading channel, the time difference between the uplink and downlink causes the null position change on the optimum array pattern. We propose a weight estimation method for the downlink null steering. It is based on the indirect weight estimation using the channel response prediction. The computer simulations show that the proposed method improves the BER performance in the downlink, effectively.
Correction: Asrij Maintains the Stem Cell Niche and Controls Differentiation during Drosophila Lymph Gland Hematopoiesis (2012)

Several signaling pathways control blood cell (hemocyte) development in the Drosophila lymph gland. Mechanisms that modulate and integrate these signals are poorly understood. Here we report that mutation in a conserved endocytic protein Asrij affects signal transmission and causes aberrant lymph gland hematopoiesis. Mammalian Asrij (Ociad1) is expressed in stem cells of the blood vascular system and is implicated in several cancers. We found that Drosophila Asrij is a panhemocyte marker and localizes to a subset of endocytic vesicles. Loss of asrij causes hyperproliferation of lymph gland lobes coupled with increased hemocyte differentiation, thereby depleting the pool of quiescent hemocyte precursors. This corelates with fewer Col+ cells in the hematopoietic stem cell niche of asrij mutants. Asrij null mutants also show excess specification of crystal cells that express the RUNX factor Lozenge (Lz), a target of Notch signaling. Asrij mutant lymph glands show increased N in sorting endosomes suggesting aberrant trafficking. In vitro assays also show impaired traffic of fluorescent probes in asrij null hemocytes. Taken together our data suggest a role for Asrij in causing increased Notch signaling thereby affecting hemocyte differentiation. Thus, conserved endocytic functions may control blood cell progenitor quiescence and differentiation.
Molecularly interconnected SiO2–GeO2 thin films: sol–gel synthesis and characterization (2000)

SiO2–GeO2 films have been synthesized by the sol–gel method starting from an ethanolic solution of Si(OC2H5)4 and Ge(OCH3)4. The coatings have been annealed in air at temperatures ranging between 300 °C and 900 °C. The compositional and microstructural evolution of the samples under thermal annealing has been investigated by X-Ray Photoelectron Spectroscopy (XPS), X-Ray Diffraction (XRD), Secondary-Ion Mass Spectrometry (SIMS) and Atomic Force Microscopy (AFM). Pure and molecularly homogeneous films have been obtained after 300 °C thermal treatment. An amorphous network of interconnected SiO4 and GeO4 tetrahedra has been observed up to 700 °C. At higher treatment temperatures the formation of crystalline silica in the cristobalite phase has been detected.
Dopamine Receptor Stimulating Effects of Chanoclavine Analogues, Tricyclic Ergot Alkaloids, in the Brain (1987)

The abilities of tricyclic ergot alkaloids, chanoclavine-l and its analogues, and bromocriptine to stimulate dopamine receptors in the brain were investigated. Receptor binding of 3H-spiperone has shown that bromocriptine exhibits clear affinity for this compound. The order of displacement potencies was bromocriptine >> ergometrine, KSU-1415 > chanoclavine-l, KSU-1118, KSU-1791. In the striatum of mice treated with an amino acid decarboxylase inhibitor, γ-butyrolactone-induced DOPA accumulation was markedly inhibited by bromocriptine and KSU-1415, but not inhibited by chanoclavine-l. In mice with unilateral striatal 6-hydroxydopamine lesions, bromocriptine and KSU-141 5 produced a long-lasting contralateral rotation that was suppressed by prior treatment with (±)-sulpiride. These results suggest that a tricyclic ergot alkaloid of the chanoclavine type stimulates D-2 receptors in the brain.
AntNet: Distributed Stigmergetic Control for Communications Networks (1998)

This paper introduces AntNet, a novel approach to the adaptive learning of routing tables in communications networks. AntNet is a distributed, mobile agents based Monte Carlo system that was inspired by recent work on the ant colony metaphor for solving optimization problems. AntNet's agents concurrently explore the network and exchange collected information. The communication among the agents is indirect and asynchronous, mediated by the network itself. This form of communication is typical of social insects and is called stigmergy. We compare our algorithm with six state-of-the-art routing algorithms coming from the telecommunications and machine learning fields. The algorithms' performance is evaluated over a set of realistic testbeds. We run many experiments over real and artificial IP datagram networks with increasing number of nodes and under several paradigmatic spatial and temporal traffic distributions. Results are very encouraging. AntNet showed superior performance under all the experimental conditions with respect to its competitors. We analyze the main characteristics of the algorithm and try to explain the reasons for its superiority.
Phase chemistry and microstructure evolution in silver-clad (Bi/sub 2-x/Pb/sub x/)Sr/sub 2/Ca/sub 2/Cu/sub 3/O/sub y/ wires (1993)

The reaction kinetics and mechanism that control the conversion of (Bi,Pb)/sub 2/Sr/sub 2/CaCu/sub 2/O/sub z/ (Bi-2212)+alkaline earth cuprates to (Bi,Pb)/sub 2/Sr/sub 2/Ca/sub 2/Cu/sub 3/O/sub y/ (Bi-2223) in silver-clad wires were investigated as a function of equilibration temperature and time at a fixed oxygen partial pressure (7.5% O/sub 2/). Measured values for the fractional conversion of Bi-2223 versus time were evaluated based on the Avrami equation. SEM studies of partially and fully converted wires suggest: (1) the transformation to Bi-2223 is two-dimensional and controlled by a diffusion process; (2) liquid phases are present during part of the Bi-2212 to Bi-2223 conversion; and (3) growth of the (Sr,Ca)/sub 14/Cu/sub 24/O/sub 41/ phase accompanies Bi-2223 formation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Control of the Spread of Vancomycin-Resistant Enterococci in Hospitals (2013)

The chain of infection can be broken by improved and consistently applied standard hygienic measures (hand and surface disinfection). Some patients are nonetheless at elevated risk of VRE infection. In specific clinical situations, the optimal protection of these patients against VRE infection demands the obligatory enforcement of stricter hygienic measures (contact isolation).
Ligand complex of RORg LBD (2019)

The further optimization of a recently disclosed series of inverse agonists of the nuclear receptor RORC2 is described. Investigations into the left-hand side of compound <b>1</b>, guided by X-ray crystal structures, led to the substitution of the 4-aryl-thiophenyl residue with the hexafluoro-2-phenyl-propan-2-ol moiety. This change resulted in to compound <b>28</b>, which combined improved drug-like properties with good cell potency and a significantly lower dose, using an early dose to man prediction. Target engagement <i>in vivo</i> was demonstrated in the thymus of mice by a reduction in the number of double positive T cells after oral dosing.
The Evaluation and Application Study of Remote Sensing Data Quality of Environment and Disaster Monitoring (2012)

The existing Fengyun (FY) satellites, resource satellites and ocean satellites all can observe the earth muti-funtionally and work well in monitoring environment and disasters. However, all these satellites are insufficient for space resolution, time resolution, spectral resolution and all-weather requirements when facing complicated environmental problems and natural disasters. This paper evaluates the multi-spectral remote sensing data quality of the Environment and Disasters Monitoring Micro-satellite Constellation (HJ-1A/B)A/B satellite and extracts data characteristics to offer references for promotion and application this data.
Phage-Bacterium War on Polymeric Surfaces: Can Surface-Anchored Bacteriophages Eliminate Microbial Infections? (2013)

These studies illustrate synthetic paths to covalently attach T1 and Φ11 bacteriophages (phages) to inert polymeric surfaces while maintaining the bacteriophage's biological activities capable of killing deadly human pathogens. The first step involved the formation of acid (COOH) groups on polyethylene (PE) and polytetrafluoroethylene (PTFE) surfaces using microwave plasma reactions in the presence of maleic anhydride, followed by covalent attachment of T1 and Φ11 species via primary amine groups. The phages effectively retain their biological activity manifested by a rapid infection with their own DNA and effective destruction of Escherichia coli and Staphylococcus aureus human pathogens. These studies show that simultaneous covalent attachment of two biologically active phages effectively destroy both bacterial colonies and eliminate biofilm formation, thus offering an opportunity for an effective combat against multibacterial colonies as well as surface detections of other pathogens.
A Novel Mobile Wallet Model for Elderly Using Fingerprint as Authentication Factor (2020)

Due to the availability of fingerprint verification technology on mobile devices, fingerprint based human identification has become the most widely used biometric technology in everyday life. The elderly find digital payment applications difficult to operate and unsecure. This work has exploited fingerprint verification availability on mobile devices to provide a user friendly and secure digital wallet payment facility to elderlies who are unable to avail this facility due to the complex infrastructure of traditional authentication mechanisms. A novel digital payment mechanism is presented which uses Bluetooth technology of mobile devices for billing at the point of sale and fingerprint verification for user authentication. A proof of the concept study is presented to validate the proposed model using state of the art usability questionnaires and attributes with the target group. The result indicates that the proposed methodology provides satisfaction and ease of use to the user.
Large scale extraction of poly(3-hydroxybutyrate) from Ralstonia eutropha H16 using sodium hypochlorite (2012)

Isolation of polyhydroxyalkanoates (PHAs) from bacterial cell matter is a critical step in order to achieve a profitable production of the polymer. Therefore, an extraction method must lead to a high recovery of a pure product at low costs. This study presents a simplified method for large scale poly(3-hydroxybutyrate), poly(3HB), extraction using sodium hypochlorite. Poly(3HB) was extracted from cells of Ralstonia eutropha H16 at almost 96% purity. At different extraction volumes, a maximum recovery rate of 91.32% was obtained. At the largest extraction volume of 50 L, poly(3HB) with an average purity of 93.32% ± 4.62% was extracted with a maximum recovery of 87.03% of the initial poly(3HB) content. This process is easy to handle and requires less efforts than previously described processes.
Phosphine Dissociation and Diffusion on Si(001) Observed at the Atomic Scale (2006)

A detailed atomic-resolution scanning tunneling microscopy (STM) and density functional theory study of the adsorption, dissociation, and surface diffusion of phosphine (PH(3)) on Si(001) is presented. Adsorbate coverages from approximately 0.01 monolayer to saturation are investigated, and adsorption is performed at room temperature and 120 K. It is shown that PH(3) dissociates upon adsorption to Si(001) at room temperature to produce both PH(2) + H and PH + 2H. These appear in atomic-resolution STM images as features asymmetric-about and centered-upon the dimer rows, respectively. The ratio of PH(2) to PH is a function of both dose rate and temperature, and the dissociation of PH(2) to PH occurs on a time scale of minutes at room temperature. Time-resolved in situ STM observations of these adsorbates show the surface diffusion of PH(2) adsorbates (mediated by its lone pair electrons) and the dissociation of PH(2) to PH. The surface diffusion of PH(2) results in the formation of hemihydride dimers on low-dosed Si(001) surfaces and the ordering of PH molecules along dimer rows at saturation coverages. The observations presented here have important implications for the fabrication of atomic-scale P dopant structures in Si, and the methodology is applicable to other emerging areas of nanotechnology, such as molecular electronics, where unambiguous molecular identification using STM is necessary.
Depletion of intracellular calcium stores by calcium ionophore A23187 induces the genes for glucose-regulated proteins in hamster fibroblasts. (1987)

Animal cells respond to calcium ionophore (A23187) treatment with the coordinate induction of a set of genes encoding proteins identical to the glucose-regulated proteins (GRPs). By monitoring the intracellular free calcium with the fluorescent indicator fura-2 while employing both intracellular and extracellular calcium buffers, we demonstrated that A23187 can induce the GRP94 and GRP78 genes without an increase in cytoplasmic calcium ([Ca2+]i). Induction of GRP mRNA during glucose starvation was also independent of [Ca2+]i. Instead, gene induction by A23187 was closely correlated with the depletion of intracellular calcium stores. We conclude that perturbations of sequestered calcium ions by A23187 can serve as a stimulus for gene expression.
Relay Hybrid Precoding Design in Millimeter-Wave Massive MIMO Systems (2018)

This paper investigates the relay hybrid precoding design in millimeter-wave massive multiple-input multiple-output systems. The optimal design of the relay hybrid precoding is highly nonconvex, due to the six-order polynomial objective function, six-order polynomial constraint, and constant-modulus constraints. To efficiently solve this challenging nonconvex problem, we first reformulate it into three quadratic subproblems, where one of the subproblems is convex and the other two are nonconvex. Then, we propose an iterative successive approximation (ISA) algorithm to attain the high-approximate optimal solution to the original problem. Specifically, in the proposed ISA algorithm, we first convert the two nonconvex subproblems to convex ones by the relaxation of the constant-modulus constraints, and then we solve the three corresponding convex subproblems iteratively. We theoretically prove that the ISA algorithm converges to a Karush-Kuhn-Tucker point of the original problem. Simulation results demonstrate that the proposed ISA algorithm achieves good performance in terms of achievable rate in both full-connected and subconnected relay hybrid precoding systems.