gebhart/patrepeval huggingface dataset:
Wireless Body Area Network in a Ubiquitous Healthcare System for Physiological Signal Monitoring and Health Consulting (2008)

We developed a ubiquitous healthcare system consisted of a physiological signal devices, a mobile system, a device provider system, a healthcare service provider system, a physician system, and a healthcare personal system. In this system, wireless body area network (WBAN) such as ZigBee is used to communicate between physiological signal devices and the mobile system. WBAN device needs a specific function for ubiquitous healthcare application. We propose a scanning algorithm, dynamic discovery and installation, reliable data transmission, device access control, and a healthcare profile for ubiquitous healthcare system.
Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy (2006)

Bestatin, a specific inhibitor of aminopeptidase N (CD13), has been reported to prolong survival time in patients with completely resected stage I lung squamous cell carcinoma. Considering the antitumor mechanism of Bestatin, it is interesting to know whether CD13 is expressed in human lung squamous cell carcinoma. The immunohistochemical expression of CD13 was examined in human lung carcinoma and the question of whether CD13 was immunohistochemically expressed in the interstitial tissue was investigated, mainly in the fibroblasts and blood vessels, surrounding the tumor nests of various kinds of non-small cell lung cancers, especially of squamous cell carcinomas. In Japanese squamous cell carcinoma of the lung, 38 (61.3%) out of 62 cancers were positively stained in the same manner on immunohistochemistry for CD13. The area of interstitial tissue positively stained for CD13 varied depending on the case. To confirm the cell nature of the interstitial tissue with CD13 positivity, double immunohistochemistry using CD34 and alpha-smooth muscle actin was performed. Double immunohistochemistry showed that the majority of CD13-positive cells were slender fibroblastic cells around the blood vessels and some endothelial cells.
Thalamic stimulation for the treatment of midline tremors in essential tremor patients (2000)

The authors prospectively collected unblinded data from 27 consecutive patients following thalamic stimulation. A significant reduction of midline tremor was achieved after unilateral surgery, but a staged contralateral surgery had an additional effect. A subgroup analysis showed significant beneficial effects for head, voice, tongue, and face tremor. The most frequent reversible side effects were disequilibrium, dysarthria, and paresthesias. We observed more pulse generator adjustments for speech problems in the bilaterally implanted group.
Simulation based investigation of source-detector configurations for non-invasive fetal pulse oximetry (2015)

Abstract Transabdominal fetal pulse oximetry is a method to monitor the oxygen supply of the unborn child non-invasively. Due to the measurement setup, the received signal of the detector is composed of photons coding purely maternal and photons coding mixed fetal-maternal information. To analyze the wellbeing of the fetus, the fetal signal is extracted from the mixed component. In this paper we assess source-detector configurations, such that the mixed fetal-maternal components of the acquired signals are maximized. Monte-Carlo method is used to simulate light propagation and photon distribution in tissue. We use a plane layer and a spherical layer geometry to model the abdomen of a pregnant woman. From the simulations we extracted the fluence at the detector side for several source-detector distances and analyzed the ratio of the mixed fluence component to total fluence. Our simulations showed that the power of the mixed component depends on the source-detector distance as expected. Further we were able to visualize hot spot areas in the spherical layer model where the mixed fluence ratio reaches the highest level. The results are of high importance for sensor design considering signal composition and quality for non-invasive fetal pulse oximetry.
Feature consistency in compile-time-configurable system software (2011)

Much system software can be configured at compile time to tailor it with respect to a broad range of supported hardware architectures and application domains. A good example is the Linux kernel, which provides more than 10,000 configurable features, growing rapidly.
Das Verfassungssystem (1978)

ZusammenfassungGrundlegend für das Verständnis der spanischen Verfassungsstruktur ist, „daß wir nicht eine geschichtlich, überkommene, in der Gewohnheit wurzelnde Verfassung vor uns haben, sondern eine revolutionäre Verfassungsordnung, das Werk einer echten verfassungsgebenden Gewalt. Es will aber außerdem heißen, daß diese Verfassungsordnung sich erst in einem Prozeß bildet“.1) Es handelt sich also um eine sich evolutionär entwickelnde Verfassung.
Identifying emotions expressed by mobile users through 2D surface and 3D motion gestures (2012)

Only intrusive and expensive ways of precisely expressing emotions has been proposed, which are not likely to appear soon in everyday Ubicomp environments. In this paper, we study to which extent we can identify the emotion a user is explicitly expressing through 2D and 3D gestures. Indeed users already often manipulate mobile devices with touch screen and accelerometers. We conducted a field study where we asked participants to explicitly express their emotion through gestures and to report their affective states. We contribute by (1) showing a high number of significant correlations in 3D motion descriptors of gestures and in the arousal dimension; (2) defining a space of affective gestures. We identify (3) groups of descriptors that structure the space and are related to arousal. Finally, we provide with (4) a preliminary model of arousal and we identify (5) interesting patterns in particular classes of gestures. Such results are useful for Ubicomp application designers in order to envision the use of gestures as a cheap and non-intrusive affective modality.
Extraction of Metal Salts by Mixtures of Water-Immiscible Amines and Organic Acids (Acid-Base Couple Extractants). 2. Theoretical Treatment and Analysis (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtraction of Metal Salts by Mixtures of Water-Immiscible Amines and Organic Acids (Acid-Base Couple Extractants). 2. Theoretical Treatment and AnalysisAharon M. Eyal, Leni Kogan, and Eyal BresslerCite this: Ind. Eng. Chem. Res. 1994, 33, 5, 1076–1085Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/ie00029a002https://doi.org/10.1021/ie00029a002research-articleACS PublicationsRequest reuse permissionsArticle Views268Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
One‐step RNA pathogen detection with reverse transcriptase activity of a mutated thermostable <i>Thermus aquaticus</i> DNA polymerase (2010)

We describe the cloning and characterization of a mutated thermostable DNA polymerase from Thermus aquaticus (Taq) that exhibits an increased reverse transcriptase activity and is therefore designated for one-step PCR pathogen detection using established real-time detection methods. We demonstrate that this Taq polymerase mutant (Taq M1) has similar PCR sensitivity and nuclease activity as the respective Taq wild-type DNA polymerase. In addition, and in marked contrast to the wild-type, Taq M1 exhibits a significantly increased reverse transcriptase activity especially at high temperatures (>60 degrees C). RNA generally hosts highly stable secondary structure motifs, such as hairpins and G-quadruplexes, which complicate, or in the worst case obviate, reverse transcription (RT). Thus, RT at high temperatures is desired to weaken or melt secondary structure motifs. To demonstrate the ability of Taq M1 for RNA detection of pathogens, we performed TaqMan probe-based diagnostics of Dobrava viruses by one-step RT-PCR. We found similar detection sensitivities compared to commercially available RT-PCR systems without further optimization of reaction parameters, thus making this enzyme highly suitable for any PCR probe-based RNA detection method.
Review of 3D printable hydrogels and constructs (2018)

Three dimensional (3D) bioprinting technologies with appropriate bioinks are potentially able to fabricate artificial tissues or organs with precise control. A bioink is a mixture of biomaterial and living cells, which is a biomaterial for bioprinting. Hydrogels are the most appealing candidates of biomaterials because they have many similar features of the natural extracellular matrix and could also provide a highly hydrated environment for cell proliferation. In this field of bio-fabrication, particularly in bioprinting, the lack of suitable hydrogels remains a major challenge. Thus, choosing appropriate hydrogels for bioprinting is the key to print self-supporting 3D constructs. Most importantly, the considerations regarding the bioinks and the obtained constructs should be made clear. This review aims to provide the specific considerations regarding the important properties of a potential bioink and the generated 3D construct, including rheological, interfacial, structural, biological, and degradation properties, which are crucial for printing of complex and functional 3D structures. Among all of the above considerations, interfacial bonding is one of the important considerations of successfully obtaining a 3D structure. Unfortunately, it is rarely mentioned in the prior literature. This review also points out, for the first time, the characterization of a potential bioink from a rheological point of view. To provide readers with an understanding of the background, the review will first present current technologies for bioprinting and their limitations. Following this will be a summary and discussion of some frequently used hydrogels for bioprinting, and their respective limitations as well. The readers will be informed on the current limitations and achievements in 3D bioprinting. This review ultimately intends to help researchers to select or develop suitable bioinks for successfully bioprinting 3D constructs.
Identifying Active Sites for Parasitic Reactions at the Cathode–Electrolyte Interface (2019)

Nickel-rich transition metal oxides are the most promising high-voltage and high-capacity cathode materials for high-energy-density lithium batteries. Improving the chemical/electrochemical stability of the cathode-electrolyte interface has been the major technical focus to enable this class of cathode materials. In this work, LiCoO<sub>2</sub> is adopted as the model cathode material to investigate the active sites for parasitic reactions between the delithiated cathode and the nonaqueous electrolyte. Both ab initio calculations and experimental results clearly show that the partially coordinated transition metal atoms at the surface are responsible for the parasitic reactions at the cathode-electrolyte interface. This finding lays out fundamental support for rational interfacial engineering to further improve the life and safety characteristics of nickel-rich cathode materials.
Extracting context from environmental audio (2002)

When notifying the user about an appointment, message arrival, or other timely event, the wearable should not blindly sound an alarm (visual or auditory). Integration with the user requires the wearable to be aware of the user's situational context. Is the user in a conversation? On the phone or with someone nearby? Who? Is the user driving in his car, walking down the street, or sitting at his desk? We have developed a system that allows us to infer environmental context by audio classification. It was designed using a statistical/pattern recognition framework called Hidden Markov Models (HMM) that allow us to recognize classes of sounds given enough examples from each class.
Effectiveness of the dual specific Src/Abl kinase inhibitor AZD0530 in combination with tamoxifen in preventing acquired anti-estrogen resistance in breast cancer cells (2007)

14054 Background: AZD0530 is a novel, orally potent, once-daily, highly selective and dual-specific Src/Abl kinase inhibitor with potential for activity in a wide range of tumors. In the context of breast cancer, where tamoxifen resistance presents a major problem, Src inhibition may be a particularly valuable therapeutic strategy since we have previously observed that elevated Src kinase activity accompanies anti-estrogen resistance in vitro, promoting an aggressive cell phenotype. Here, we have explored the potential therapeutic effects of Src inhibition with AZD0530, alone and in combination with tamoxifen, on the acquisition of endocrine resistance in breast cancer cells. Methods: MCF7 and T47D breast cancer cells were exposed to tamoxifen (10–7 M), AZD0530 (1 μM), or both agents in combination for a minimum of 10 months with passaging as necessary, or until total cell death occurred. Cells were assayed at monthly intervals for intracellular signaling pathway activity (Western Blotting) and in vitro invasive capacity (Matrigel invasion assays). Apoptosis and proliferation were assessed by ELISA and Ki67 staining, respectively. Changes in c-Myc and cyclin-D1 were measured with RT-PCR. Results: Treatment of cells with tamoxifen alone ultimately resulted in acquired resistance, elevated Src kinase activity, and a Src- dependent increase in invasive capacity. Chronic exposure to AZD0530 alone resulted in outgrowth of AZD0530 resistant cells, in which Src kinase activity remained suppressed as did their in vitro invasiveness. Treatment of MCF7 and T47D cells with AZD0530 and tamoxifen combined resulted in a reduction of Src, FAK, and Akt activity, inhibition of c-Myc gene expression, and complete abrogation of their in vitro invasive behavior. Furthermore, combination treatment completely prevented cell proliferation and the subsequent emergence of a resistant phenotype, with a total loss of cells by 12 weeks. Conclusions: Inhibition of Src kinase with AZD0530, when used in conjunction with anti-estrogen therapies, effectively prevents acquired resistance in breast cancer cells in vitro suggesting a potential novel therapeutic benefit of Src kinase inhibitors clinically. No significant financial relationships to disclose.
A placebo‐controlled pilot study of a wearable morning bright light treatment for probable PTSD (2019)

The Re-timer® was well tolerated and the perceived benefit was high, though treatment adherence was only moderate. Those in the active group were more likely to achieve a minimal clinically important change in PTSD and depression symptoms and had larger symptom reductions than those in the placebo group CONCLUSIONS: A wearable morning light treatment was acceptable and feasible for patients with probable PTSD. This study provides initial proof-of-concept that light treatment can improve PTSD. A larger trial is warranted to establish treatment efficacy. NCT#: 03513848.
<title>Piezoelectric tubes and 1-3-type tubular composites as tunable actuators and sensors</title> (1993)

Piezoelectric actuators and sensors made of tubular structure can provide a great agility of the effective response in the radial direction. For a radially poled piezoelectric tube, the effective piezoelectric constant in that direction can be tuned to be positive, zero, and negative by varying the ratio of the outer radius (R<SUB>0</SUB>) to the inner radius (r<SUB>0</SUB>) of the tube. For a suitable ratio of R<SUB>0</SUB>/r<SUB>0</SUB>, this effective constant can also be changed in sign or set to zero by adjusting the dc bias field level for tubes made of electrostrictive materials. Therefore, one can make a piezoelectric transducer with all the effective piezoelectric tensile constants having the same sign. The end capped thin wall tubes also exhibit exceptionally high hydrostatic response and the small size of the tubular structure makes it very suitable for integration into 1 - 3 composite which possesses low acoustic impedance and high hydrostatic response.
Safe human-robot-coexistence: emergency-stop using a high-speed vision-chip (2005)

The coexistence of humans and industrial robots in a common workspace provides the advantage of increased flexibility in production or longer system up-time during maintenance. However, it is fundamentally necessary to guarantee the safety of the human. This paper presents an approach that uses a specialized tracking-vision-chip to realize a high-speed emergency-stop for safe human-robot-coexistence. The presented approach uses the ability of the vision-chip to perform pixel-parallel masking and fast summation-operations on binary images to detect whether the robot and human are too close. After initial evaluation in a (semi)-simulation, the approach was realized in an experimental system. Even with only a small 8-bit microcontroller controlling the vision-chip and the communication, a cycle time of more than 500Hz was achieved.
Three-dimensional architecture for solid state radiation detectors (2023)

A radiation-damage resistant radiation detector is formed on a substrate formed of a material doped with a first conductivity type dopant. The detector includes at least one first electrode formed of first conductivity type dopant, and at least one second electrode that is spaced-apart from the first electrode and formed of a second conductivity type dopant. Each first and second electrode penetrates into the substrate from a substrate surface, and one or more electrodes may penetrate entirely through the substrate, that is traversing from one surface to the other surface. Particulate and/or electromagnetic radiation penetrating at least a surface of the substrate releases electrons and holes in substrate regions. Because the electrodes may be formed entirely through the substrate thickness, the released charges will be a relatively small distance from at least a portion of such an electrode, e.g., a distance less than the substrate thickness. The electrons and/or holes traverse the small distance and are collected by said electrodes, thus promoting rapid detection of the radiation. By providing one or more electrodes with a dopant profile radially graded in a direction parallel to a substrate surface, an electric field results that promotes rapid collection of released electrons and said holes. Monolithic combinations of such detectors may be fabricated including CMOS electronics to process radiation signals.
Hydrogen Induced Cracking of API X52 and X60 Sour Service Steels Subjected to Pre-Strain under Prolonged H<sub>2</sub>S Exposure (2019)

Abstract The effect of plastic deformation on API X52 and X60 sour service steels on hydrogen induced cracking was studied. Plastic deformation was performed with a tensile pre-strain with the percentage variation of strain. The HIC test was carried out with a duration of 168 hours of hydrogen charging to investigate the cracking behavior. After hydrogen charging, the cross sections of both steels were observed to find out hydrogen cracks. Ultrasonic testing was carried out on the specimen surface to see the distribution of laminated cracks. The hydrogen crack surface was observed using SEM. The results showed that the values of CSR, CLR and CTR increased with increasing percentage of pre-strain. Ultrasonic testing showed that the area influenced by HIC increased with increasing percentage of pre-strain. The susceptibility of API X52SS and X60SS to HIC increases with increasing percent of pre-strain. API Steel X52SS has better HIC resistance than X60SS on high pre-strain.
Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2 (2014)

The poly(ADP-ribose) polymerase (PARP) family represents a new class of therapeutic targets with diverse potential disease indications. PARP1 and PARP2 inhibitors have been developed for breast and ovarian tumors manifesting double-stranded DNA-repair defects, whereas tankyrase 1 and 2 (TNKS1 and TNKS2, also known as PARP5a and PARP5b, respectively) inhibitors have been developed for tumors with elevated β-catenin activity. As the clinical relevance of PARP inhibitors continues to be actively explored, there is heightened interest in the design of selective inhibitors based on the detailed structural features of how small-molecule inhibitors bind to each of the PARP family members. Here, the high-resolution crystal structures of the human TNKS2 PARP domain in complex with 16 various PARP inhibitors are reported, including the compounds BSI-201, AZD-2281 and ABT-888, which are currently in Phase 2 or 3 clinical trials. These structures provide insight into the inhibitor-binding modes for the tankyrase PARP domain and valuable information to guide the rational design of future tankyrase-specific inhibitors.
Catalytic Coupling of C−H and C−I Bonds Using Pyridine As a Directing Group (2005)

A method for the palladium-catalyzed arylation of pyridines and pyrazoles has been developed. Both aliphatic and aromatic C-H bonds may be functionalized using this method. A bromo substituent is tolerated on the aryl iodide coupling component. [reaction: see text]
Stability of Perovskite Oxide Electrode with Stabilized Zirconia (1989)

High temperature interactions between yttria-stabilized zirconia and lanthanum manganite, which are the prime candidates for the electrolyte and the air electrode material for solid oxide fuel cells, respectively, have been investigated. The pellets prepared by pressing a powder mixture of ZrO2 with 8 mole % Y2O3 (8YSZ) and (La,Sr)1−xMnO3 were allowed to react in open air at 1200–1350 °C and analyzed by X-ray diffraction to examine the reaction products. At 1200°C, stoichiometric LaMnO3 reacted with 8YSZ and produced La2Zr2O7 with the reaction time of 24h. On the other hand, no reaction product was observed for the mixture of La deficient La0.8MnO3 and 8YSZ for 192h at 1200°C. At a much higher temperature of 1300°C, La2Zr2O7 was observed in all the mixtures of (La,Sr)1−xMnO3(x =0–0.2) and 8YSZ for 50h, but the reaction kinetics for the La deficient La1−xMnO3 and 8YSZ was slower.