gebhart/patrepeval huggingface dataset:
Surface laser scanning to routinely produce casts for patient immobilization during radiotherapy* (2007)

Immobilization casts are used to reduce patient movement during the radiotherapy of head and neck and brain malignancies. Polyethylene-based casts are produced by first taking a Plaster of Paris 'negative' impression of the patient. A 'positive' mould is then made, which is used to vacuum form an immobilization cast. Taking the 'negative' cast can be messy, stressful for patients and labour intensive. Recently, lightweight hand-held laser surface scanners have become available. These allow an accurate 3-D representation of objects to be generated non-invasively. This technology has now been applied to the production of casts for radiotherapy. Each patient's face and head is digitized using the Polhemus FastSCAN (Polhemus, Colchester, VT, USA) scanner. The electronic data are transferred to a computer numerical controlled mill, where a positive impression is machined. The feasibility of the process was examined, the labour required and radiation therapists' satisfaction with aspects of the produced masks assessed. The scanner-based method of mask production was found to be simple, accurate and non-invasive. There was a reduction in radiation therapist labour required. Masks produced with the scanner-based method were reported to result in improved mask fitting, daily reproducibility, patient immobilization and patient comfort.
The NF1 somatic mutational landscape in sporadic human cancers (2017)

As neurofibromin activity is a key to regulating the RAS/MAPK pathway, NF1 mutations are important in the acquisition of drug resistance, to BRAF, EGFR inhibitors, tamoxifen and retinoic acid in melanoma, lung and breast cancers and neuroblastoma. Other curiosities are observed, such as a high rate of somatic NF1 mutation in cutaneous melanoma, lung cancer, ovarian carcinoma and glioblastoma which are not usually associated with neurofibromatosis type 1. Somatic NF1 mutations may be critical drivers in multiple cancers. The mutational landscape of somatic NF1 mutations should provide novel insights into our understanding of the pathophysiology of cancer. The identification of high frequency of somatic NF1 mutations in sporadic tumours indicates that neurofibromin is likely to play a critical role in development, far beyond that evident in the tumour predisposition syndrome NF1.
Wearable wireless sensor patch for continuous monitoring of skin temperature, pressure, and relative humidity (2017)

This paper describes system design issues involved in the development of a wearable wireless sensor system for continuous monitoring of skin pressure, temperature, and relative humidity. The system is intended for prevention of pressure ulcers (bedsores), and would alert a patient or caregiver to a potentially harmful level of contact pressure or adverse microclimate that could cause tissue damage. Implementation of this system would reduce health care costs by improving pressure ulcer prevention, enabling patient treatment and monitoring outside a hospital setting, and easing workload on caregivers.
Family violence screening and disclosure response: A public mental health service consumer survey. (2023)

<ns3:p><ns3:bold>Background</ns3:bold>: Family violence (FV) is a significant problem that has a bidirectional link with mental health functioning. This research aimed to investigate family violence screening and response practices in a Victorian public adult mental health service, NorthWestern Mental Health, from the consumer perspective. </ns3:p><ns3:p> <ns3:bold>Methods</ns3:bold>: A prospective, cross-sectional, electronic consumer survey was created, utilising the Royal Melbourne Hospital Patient Survey FV screening and response tool. Data were collected over a two-month time period, via ipad. Clinicians invited all consumers (age range 18 to 64 years) attending the service to participate on data collection days, unless any of the exclusion criteria were present: a) clinical interaction occurring in a non-confidential environment; b) acute distress/crisis; c) clinician concerns about affecting rapport; and d) cognitive impairment, known disability or diminished capacity preventing them from reading or understanding the survey questions. Categorical and Likert type survey responses were explored descriptively. All variables collected in the survey were provided, specifically the percentage of responses in each category for each question. Free-text responses were analysed using qualitative description of the text-box response content.</ns3:p><ns3:p> <ns3:bold>Results</ns3:bold>: 35 consumers participated. 47% reported being screened for at least one family violence issue on at least one occasion. 26% reported disclosing FV concerns. All those disclosing felt mildly or very supported by the clinician’s response, and two-thirds received assistance they found helpful. 9% reported wanting to disclose FV concerns but not feeling comfortable to do so. Consumers indicated that FV should be spoken about more, that receiving assistance is helpful, but that responses varied in quality depending on the discipline of the clinician. </ns3:p><ns3:p> <ns3:bold>Conclusion</ns3:bold>: FV screening rates were found to be suboptimal as unmet needs were identified. Further training and services changes are required to improve screening rates, increase client comfort to disclosure, and optimise the clinical response to disclosures.</ns3:p>
MobilityFirst (2014)

MobilityFirst is a future Internet architecture with mobility and trustworthiness as central design goals. Mobility means that all endpoints -- devices, services, content, and networks -- should be able to frequently change network attachment points in a seamless manner. Trustworthiness means that the network must be resilient to the presence of a small number of malicious endpoints or network routers. MobilityFirst enhances mobility by cleanly separating names or identifiers from addresses or network locations, and enhances security by representing both in an intrinsically verifiable manner, relying upon a massively scalable, distributed, global name service to bind names and addresses, and to facilitate services including device-to-service, multicast, anycast, and context-aware communication, content retrieval, and more. A key insight emerging from our experience is that a logically centralized global name service can significantly enhance mobility and security and transform network-layer functionality. Recognizing and validating this insight is the key contribution of the MobilityFirst architectural effort.
Software cost estimation with fuzzy models (2000)

Estimation of effort/cost required for development of software products is inherently associated with uncertainty. In this paper, we are concerned with a fuzzy set-based generalization of the COCOMO model (f-COCOMO). The inputs of the standard COCOMO model include an estimation of project size and an evaluation of other parameters. Rather than using a single number, the software size can be regarded as a fuzzy set (fuzzy number) yielding the cost estimate also in form of a fuzzy set. The paper includes detailed results with this regard by relating fuzzy sets of project size with the fuzzy set of effort. The analysis is carried out for several commonly encountered classes of membership functions (such as triangular and parabolic fuzzy sets). The issue of designer-friendliness of the f-COCOMO model is discussed in detail. Here we emphasize a way of propagation of uncertainty and ensuing visualization of the resulting effort (cost). Furthermore we augment the model by admitting software systems to belong partially to the three main categories (namely embedded, semidetached and organic) and discuss key implications of this generalization and highlight its links with a generalized sensitivity analysis. The experimental part of the study illustrates the approach and contrasts it with the standard numeric version of the COCOMO model.
The Role of ZIP4 in Homologous Chromosome Synapsis and Crossover Formation in Rice Meiosis (2012)

In budding yeast, the ZMM complex is closely associated with class I crossovers and synaptonemal complex (SC) formation. However, the relationship between the ZMM genes remains unclear in most higher eukaryotes. Here, we identify the rice ZIP4 homolog, a member of the ZMM gene group, and explore its relationship with two other characterized ZMM genes, MER3 and ZEP1. Our results show that in the rice zip4 mutant, the chiasma frequency is greatly reduced, although synapsis proceeds with only mild defects. Immunocytological analyses of wild-type rice reveal that ZIP4 presents as punctuate foci and colocalizes with MER3 in prophase I meiocytes. Additionally, ZIP4 is essential for the loading of MER3 onto chromosomes, but not vice versa. Double-mutant analyses show that zip4 mer3 displays a greater decrease in the mean number of chiasmata than either of the zip4 or mer3 single mutants, suggesting that ZIP4 and MER3 work cooperatively to promote CO formation but their individual contributions are not completely identical in rice. Although zep1 alone gives an increased chiasma number, both zip4 zep1 and mer3 zep1 show a much lower chiasma number than the zip4 or mer3 single mutants. These results imply that the normal functions of ZIP4 and MER3 are required for the regulation of COs by ZEP1.
A Synthesis-Quality-Oriented Depth Refinement Scheme for MPEG Free Viewpoint Television (FTV) (2009)

This paper addresses the problem of refining depth information from the received reference and depth images within the MPEG FTV framework. An analytical model is first developed to approximate the per-pixel synthesis distortion (caused by depth-image compression) as a function of depth-error variances, intensity variations, ground-truth depth and virtual camera locations. We then follow the model to detect unreliable depth pixels by inspecting intensity gradients and to refine their values with a candidate-based block disparity search. Additional side information is transmitted to make both operations robust against compression effects. Experimental results show that our scheme offers an average PSNR improvement of 1.2 dB over MPEG FTV and consistently outperforms the state-of-the-art methods. Moreover, it can remove synthesis artifacts to a great extent, producing a result that is very close in appearance to the ground-truth view image.
Practical, Real-time Centralized Control for CDN-based Live Video Delivery (2015)

Live video delivery is expected to reach a peak of 50 Tbps this year. This surging popularity is fundamentally changing the Internet video delivery landscape. CDNs must meet users' demands for fast join times, high bitrates, and low buffering ratios, while minimizing their own cost of delivery and responding to issues in real-time. Wide-area latency, loss, and failures, as well as varied workloads ("mega-events" to long-tail), make meeting these demands challenging.
Reactions of Silicon and Germanium with Halogens, Their Hydrides, and Organic Halogen Derivatives (1974)

Results published up to 1972 inclusive on the kinetics and the mechanism of the reactions of silicon and germanium with halogens, their hydrides, and organic derivatives are summarised. The kinetics and the mechanism of formation of the most important organic and halogenated derivatives of silicon and germanium, which have found wide industrial application, are discussed. Published data are analysed in the light of modern views on the progress of heterogeneous catalytic reactions. A list of 163 references is included.
Complexes of γ‐Cyclodextrin with Crown Ethers, Cryptands, Coronates, and Cryptates (1979)

Cascade complexes are comparable with a set of three interfitting dolls: γ-cyclodextrin (γ-CD)—a ring of eight glucose molecules—accommodates a small crown ether (see model) or cryptand, which in turm can take up a cation. The [12] crown-4-LiSCN complex and the [2.2.1] ⊂ Ca(SCN)2 cryptate from crystalline cascade complexes of stoichiometry 1:1 and 2:1, respectively, with γ-CD from aqueous solution.
Improved isobaric tandem mass tag quantification by ion mobility mass spectrometry (2014)

The results of this investigation demonstrate proof-of-principle that IM separation of tagged precursors prior to MS/MS fragmentation can help mitigate quantitative inaccuracies caused by isobaric interference. Future improvements of the method would include software for automated correction and use of higher resolution IM instrumentations.
Selecting a Decongestant (1993)

Antihistamines and decongestants often are used interchangeably and in combination for a variety of upper respiratory illnesses ranging from allergic rhinitis to the common cold; yet, these two classes of drugs have distinct therapeutic actions. When administered alone, antihistamines are of no value in reducing nasal stuffiness. Therefore, many allergy products also contain decongestants. Conversely, cough-cold remedies often contain antihistamines despite their lack of efficacy in these conditions. Nasal congestion, on the other hand, regardless of its cause, responds quite well to decongestants. The topical route provides a faster and more intense decrease in nasal airway resistance, but has a shorter duration and the potential to produce rebound congestion in patients with allergic rhinitis, whereas oral agents do not. Phenylpropanolamine, pseudoephedrine, and phenylephrine are the most common decongestants. Although all are sympathomimetic amines, their efficacy varies. In particular, phenylephrine is subject to first-pass metabolism and therefore is not bioavailable in currently recommended doses. In addition, phenylpropanolamine and pseudoephedrine, but not phenylephrine, are effective decongestants. Slow-release formulations allow a longer dosing interval, especially during the night. However, most formulations available in the United States are manufactured and sold without Food and Drug Administration scrutiny. Since the in vitro dissolution of many of these products differs, it is possible that some of the generic formulations are not bioequivalent to established brand-name products. Therefore, pharmacists should not substitute formulations without discussing the matter with the prescriber.
Radiofrequency Puncture of the Fossa Ovalis for Resistant Transseptal Access (2008)

Transmission of RF energy from the ablation catheter up to the tip of the transseptal needle provides an easy and safe method for piercing the fossa ovalis when the conventional approach fails because of a resistant septum.
Techniques for Gamut Surface Definition and Visualization (1997)

Color gamut mapping plays a crucial role in color management. Accurate techniques for defining and visualizing a device's gamut boundary are very important in the design of robust color gamut mapping algorithms. A novel technique for defining the surface of a color imaging device's gamut in CIELAB L*Cab*hab color space using a triangulation and interpolation process is presented. This process provides an accurate approach for gamut surface fitting, from measured or modeled data, that is independent of gamut concavity or convexity. The results of a goodness-of-fit test indicate that the gamut surface can be predicted to a mean ΔEab* of 1.1, for the CRT gamut tested. In addition the L*Cab*hab space has been shown to be useful for several gamut mapping and visualization tasks. Finally, an L*Cab*hab gamut is given for an HP Deskjet 870Cxi inkjet printer that was derived from measured data.
Feature-Based Sparse Representation for Image Similarity Assessment (2011)

Assessment of image similarity is fundamentally important to numerous multimedia applications. The goal of similarity assessment is to automatically assess the similarities among images in a perceptually consistent manner. In this paper, we interpret the image similarity assessment problem as an information fidelity problem. More specifically, we propose a feature-based approach to quantify the information that is present in a reference image and how much of this information can be extracted from a test image to assess the similarity between the two images. Here, we extract the feature points and their descriptors from an image, followed by learning the dictionary/basis for the descriptors in order to interpret the information present in this image. Then, we formulate the problem of the image similarity assessment in terms of sparse representation. To evaluate the applicability of the proposed feature-based sparse representation for image similarity assessment (FSRISA) technique, we apply FSRISA to three popular applications, namely, image copy detection, retrieval, and recognition by properly formulating them to sparse representation problems. Promising results have been obtained through simulations conducted on several public datasets, including the Stirmark benchmark, Corel-1000, COIL-20, COIL-100, and Caltech-101 datasets.
South Africa - The Roundabout Outdoor Playpump (2002)

Hand pumps are physically grueling for women and wasteful of a strained resource. Now a patented South African invention the Roundabout Playpump simplifies the whole exercise by providing a maintenance-free pump that is easy to use and provides many other social and environmental benefits.
Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction (1993)

Purine nucleoside phosphorylase from calf spleen catalyzes the arsenolysis of inosine to form hypoxanthine and ribose 1-arsenate, which spontaneously hydrolyzes to ribose and arsenate. In the presence of H2(18)O, no 18O is incorporated into ribose, demonstrating that ribose 1-arsenate hydrolysis occurs by attack of water on the arsenic atom. Rapid reaction kinetics at 20 degrees C result in a biphasic rate curve with the first turnover occurring at a rate of 20 s-1 followed by a steady-state rate of 2 s-1. The product burst is consistent with rapid steps for substrate binding and arsenolysis followed by rate-limiting hypoxanthine release at a rate of 2 s-1. Purine nucleoside phosphorylase with bound [14C]inosine was mixed with excess unlabeled inosine and arsenate to determine relative rates for reaction or dissociation of bound inosine. The commitment factor (product formed/inosine released) was 0.19 at saturating arsenate, indicating that inosine binds to free enzyme and that bound inosine is not in thermodynamic equilibrium with free substrate. At neutral pH, kinetic isotope effects for the phosphorolysis reaction are small, indicating kinetic suppression. Kinetic isotope effects for arsenolysis were measured with [1'-3H]-, [2'-3H]-, [1'-14C]-, [9-15N]-, [4'-3H]-, and [5'-3H]inosine to provide experimental values of 1.118 +/- 0.003, 1.128 +/- 0.003, 1.022 +/- 0.005, 1.009 +/- 0.004, 1.007 +/- 0.003 and 1.028 +/- 0.004 respectively. Following correction for commitment factors, the intrinsic isotope effects were matched to a geometric transition-state model selected by bond-energy bond order vibrational analysis.(ABSTRACT TRUNCATED AT 250 WORDS)
Effect of Endothelin 1 on Fibrinolysis and Plasminogen Activator Inhibitor 1 Synthesis in Rat Mesangial Cells (1996)

Endothelins (ETs) have been known to have a variety of biological functions such as mitogenic stimulation, natriuresis and the stimulation of the proteolytic activity in addition to vasoconstrictive action, which may participate in the process of glomerular diseases pathophysiologically. In this study, the effects of ET-1 on fibrinolysis, plasminogen activator inhibitor 1 (PAI-1) synthesis and PAI-1 mRNA expression were examined in cultured rat mesangial cells (MCs). The addition of ET-1 (10(-11) to 10(-7) M) into MC cultures reduced fibrinolytic activities assayed by fibrin autography in a dose-dependent manner. For the assay of PAI-1 synthesis, MC culture media metabolically labeled with 35S-methionine were analyzed by SDS-PAGE with fluorography and immuno-precipitation using rabbit antirat PAI-1 antibody. Exposure to ET-1 for 24 h produced a clear dose-dependent effect on the PAI-1 release from the MCs. PAI-1 mRNA expression was also enhanced in parallel with the concentration of ET-1 in the conditioned media. These findings indicate that ET-1 participates in fibrinolysis and the PAI-1 synthesis by MCs, which may thus regulate the degradation of the extracellular matrix in the glomerular microenvironment.
The Role of Chemokines and their Receptors in Tumor Progression and Invasion: Potential New Targets of Biological Therapy (2005)

Chemotactic cytokines (chemokines) are a family of small proteins inducing directed cell migration (chemotaxis), via specific G-protein coupled receptors. Initially described as molecules regulating leukocyte recruitment at sites of inflammation, in the last decade, it has become increasingly clear that chemokines mediate several other functions and therefore are more than simple traffick controllers. Chemokines are produced by many different cell types, including tumor cells. Indeed, tumors are major producer of chemokines and have represented an invaluable source for their identification and characterization. In the tumor microenvironment chemokines are crucial regulators of the levels of tumorinfiltrating leukocytes. In addition, these mediators control a variety of biological activities, such as production and deposition of collagen, activation of matrix-digesting enzymes, stimulation of cell growth, inhibition of apoptosis and promotion of neo-angiogenesis. The expression of chemokines, therefore, is of potential advantage for tumor cells and may endow them with enhanced ability to proliferate and disseminate. The complex network of chemokines and their receptors in the tumor microenvironment is currently the object of an intense investigation aimed at targeting these molecules for therapeutic interventions. Keywords: chemokines, chemokine receptors, chemotaxis, tumor-associated macrophages, tumor-infiltrating leukocytes, tumor stroma, angiogenesis, matrix-metalloproteases, tumor survival, metastasis
Interaction of Thrombin-Stimulated Platelets with Vitronectin (S-Protein of Complement) Substrate: Inhibition by a Monoclonal Antibody to Glycoprotein IIb-IIIa Complex (1988)

Platelets adhere to vitronectin substrate following activation with physiological concentrations of thrombin. Adhesion of activated platelets to vitronectin substrate is dependent upon the presence of divalent cations, the amount of vitronectin, and the duration of adhesion assay. The adhesion of platelets is inhibited by synthetic peptides containing the sequence of Arg-Gly-Asp. In addition, monoclonal antibodies to glycoprotein IIb-IIIa complex inhibit the adhesion of activated platelets to vitronectin substrate in a dose-dependent manner. These studies suggest that the glycoprotein IIb-IIIa complex on activated platelets may interact with vitronectin substrate through the Arg-Gly-Asp mechanism. Since vitronectin is present in the subendothelial matrix, it might be involved in platelet-vessel wall interactions.
A general-purpose contact detection algorithm for nonlinear structural analysis codes (1993)

A new contact detection algorithm has been developed to address difficulties associated with the numerical simulation of contact in nonlinear finite element structural analysis codes. Problems including accurate and efficient detection of contact for self-contacting surfaces, tearing and eroding surfaces, and multi-body impact are addressed. The proposed algorithm is portable between dynamic and quasi-static codes and can efficiently model contact between a variety of finite element types including shells, bricks, beams and particles. The algorithm is composed of (1) a location strategy that uses a global search to decide which slave nodes are in proximity to a master surface and (2) an accurate detailed contact check that uses the projected motions of both master surface and slave node. In this report, currently used contact detection algorithms and their associated difficulties are discussed. Then the proposed algorithm and how it addresses these problems is described. Finally, the capability of the new algorithm is illustrated with several example problems.