gebhart/patrepeval huggingface dataset:
NAVIGATING A RISKY WORLD (2010)

RETURN TO ISSUEPREVBook ReviewNEXTNAVIGATING A RISKY WORLDExploring the ways people PERCEIVE RISK and how they act accordinglyGEORGE B. KAUFFMANCite this: Chem. Eng. News 2010, 88, 36, 68–70Publication Date (Print):September 6, 2010Publication History Published online27 March 2011Published inissue 6 September 2010https://pubs.acs.org/doi/10.1021/CEN082710150144https://doi.org/10.1021/CEN082710150144book-reviewACS PublicationsCopyright © 2010 AMERICAN CHEMICAL SOCIETYArticle Views10Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Atomic spectrometry update. X-ray fluorescence spectrometry (2003)

The first page of this article is displayed as the abstract.
Endocrine disorders and orthopedic problems in children (1996)

Endocrine excesses or deficiencies frequently result in alterations of height as compared with age-matched children. Less clinically obvious are significant alterations in bone metabolism leading to osteoporosis, which can affect the child and may affect the patient as an adult. Slipped capital femoral epiphysis appears to be associated with a variety of endocrine disorders, particularly hypothyroidism. The hormonal treatment of various endocrine and nonendocrine disorders has been associated with alterations of bone metabolism, or of bone maturation, as well as with producing or aggravating orthopedic disorders.
Quasi-drift diffusion model for the quantum dot intermediate band solar cell (2002)

This paper describes the application of the drift-diffusion model in order to illustrate the operation of the quantum dot intermediate band solar cell (QD-IBSC) and its validity limits. The main particularities of the model arise from the fact that the intermediate band solar cell (IBSC) is a two-minority carrier device. The role of the current transport in the IB is discussed, providing the beneficial conditions in which this current approaches zero. The electric field is also related to the current density in the intermediate band. The conditions in which the contribution of the electron and hole drift currents is small when compared to the total current are discussed. The description of the operation of the cell is aided by means of a numerical example.
Blacked Out: Racial and Gender Segregation in Gifted Education 60 Years After Brown vs. Board of Education (2014)

This article examines the under-representation of African American students in gifted education, with attention to how representation differs for Black males and females. We contend that social injustices (e.g., prejudice and discrimination) contribute to racially segregated gifted education classes (Ford, 2013b). For support, gifted under-representation trends are shared, accompanied by formulae for calculating under-representation and inequity associated with under-representation. Denying access to gifted education based on race is a violation of civil rights in education. We discuss the under-representation of Black males and females in gifted education with Brown vs. Board of Education (1954) as the legal foundation and then attend to a court case in gifted education (McFadden vs. Board of Education for Illinois School District U-46, 2013; 984 F.Supp.2d 882) for one contemporary point of discussion regarding gifted education segregation. Suggestions for desegregating gifted education are shared.
The Fanconi Anemia Polypeptide, FAC, Binds to the Cyclin-Dependent Kinase, cdc2 (1997)

Fanconi anemia (FA) is an autosomal recessive disorder characterized by developmental defects, bone marrow failure, and cancer susceptibility. Cells derived from FA patients are sensitive to crosslinking agents and have a prolonged G2 phase, suggesting a cell cycle abnormality. Although transfection of type-C FA cells with the FAC cDNA corrects these cellular abnormalities, the molecular function of the FAC polypeptide remains unknown. In the current study we show that expression of the FAC polypeptide is regulated during cell cycle progression. In synchronized HeLa cells, FAC protein expression increased during S phase, was maximal at the G2/M transition, and declined during M phase. In addition, the FAC protein coimmunoprecipitated with the cyclin-dependent kinase, cdc2. We next tested various mutant forms of the FAC polypeptide for binding to cdc2. A patient-derived mutant FAC polypeptide, containing a point mutation at L554P, failed to bind to cdc2. The FAC/cdc2 binding interaction therefore correlated with the functional activity of the FAC protein. Moreover, binding of FAC to cdc2 was mediated by the carboxyl-terminal 50 amino acids of FAC in a region of the protein required for FAC function. Taken together, our results suggest that the binding of FAC and cdc2 is required for normal G2/M progression in mammalian cells. Absence of a functional interaction between FAC and cdc2 in FA cells may underlie the cell cycle abnormality and clinical abnormalities of FA.
Optimization of off-null ellipsometry in sensor applications (2004)

The optimization of azimuth angle settings of a polarizer-compensator-sample-analyzer off-null ellipsometric sensor system to obtain maximum intensity changes with respect to changes in the properties of a sensing layer, with and without considering changes in s reflectance, is studied. Optimal conditions in the two cases are derived analytically under the assumption that linear relationships exist among the changes in the parameters of the sensing layer. The validity of these optimal conditions is verified by numerical examples. The advantage of using ellipsometry compared with reflectometry to readout sensing information for some sensing samples is also discussed.
Solubility enhancement of aggregation-prone heterologous proteins by fusion expression using stress-responsive Escherichia coliprotein, RpoS (2008)

Abstract Background The most efficient method for enhancing solubility of recombinant proteins appears to use the fusion expression partners. Although commercial fusion partners including maltose binding protein and glutathione- S -transferase have shown good performance in enhancing the solubility, they cannot be used for the proprietory production of commercially value-added proteins and likely cannot serve as universal helpers to solve all protein solubility and folding issues. Thus, novel fusion partners will continue to be developed through systematic investigations including proteome mining presented in this study. Results We analyzed the Escherichia coli proteome response to the exogenous stress of guanidine hydrochloride using 2-dimensional gel electrophoresis and found that RpoS (RNA polymerase sigma factor) was significantly stress responsive. While under the stress condition the total number of soluble proteins decreased by about 7 %, but a 6-fold increase in the level of RpoS was observed, indicating that RpoS is a stress-induced protein. As an N-terminus fusion expression partner, RpoS increased significantly the solubility of many aggregation-prone heterologous proteins in E. coli cytoplasm, indicating that RpoS is a very effective solubility enhancer for the synthesis of many recombinant proteins. RpoS was also well suited for the production of a biologically active fusion mutant of Pseudomonas putida cutinase. Conclusion RpoS is highly effective as a strong solubility enhancer for aggregation-prone heterologous proteins when it is used as a fusion expression partner in an E. coli expression system. The results of these findings may, therefore, be useful in the production of other biologically active industrial enzymes, as successfully demonstrated by cutinase.
Opinion Tribunal Review of Social Security Compliance Penalty Decisions (2010)

Several issues related to social security compliance penalty decisions are examined in the context of Tribunal review. The issue is discussed with reference to the 'Social Security (Administration) Act 1999' (Cth). It is suggested that applicants could challenge some of the previous approaches taken in the Administrative Appeals Tribunal.
Precise in-frame integration of exogenous DNA mediated by CRISPR/Cas9 system in zebrafish (2015)

The CRISPR/Cas9 system provides a powerful tool for genome editing in various model organisms, including zebrafish. The establishment of targeted gene-disrupted zebrafish (knockouts) is readily achieved by CRISPR/Cas9-mediated genome modification. Recently, exogenous DNA integration into the zebrafish genome via homology-independent DNA repair was reported, but this integration contained various mutations at the junctions of genomic and integrated DNA. Thus, precise genome modification into targeted genomic loci remains to be achieved. Here, we describe efficient, precise CRISPR/Cas9-mediated integration using a donor vector harbouring short homologous sequences (10-40 bp) flanking the genomic target locus. We succeeded in integrating with high efficiency an exogenous mCherry or eGFP gene into targeted genes (tyrosinase and krtt1c19e) in frame. We found the precise in-frame integration of exogenous DNA without backbone vector sequences when Cas9 cleavage sites were introduced at both sides of the left homology arm, the eGFP sequence and the right homology arm. Furthermore, we confirmed that this precise genome modification was heritable. This simple method enables precise targeted gene knock-in in zebrafish.
Inactivating Variants in <i>ANGPTL4</i> and Risk of Coronary Artery Disease (2016)

Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers. The inhibition of Angptl4 in mice and monkeys also resulted in corresponding reductions in these values. (Funded by Regeneron Pharmaceuticals.).
Mesenchymal stem cells: characteristics and clinical applications. (2006)

Mesenchymal stem cells (MSCs) are bone marrow populating cells, different from hematopoietic stem cells, which possess an extensive proliferative potential and ability to differentiate into various cell types, including: osteocytes, adipocytes, chondrocytes, myocytes, cardiomyocytes and neurons. MSCs play a key role in the maintenance of bone marrow homeostasis and regulate the maturation of both hematopoietic and non-hematopoietic cells. The cells are characterized by the expression of numerous surface antigens, but none of them appears to be exclusively expressed on MSCs. Apart from bone marrow, MSCs are located in other tissues, like: adipose tissue, peripheral blood, cord blood, liver and fetal tissues. MSCs have been shown to be powerful tools in gene therapies, and can be effectively transduced with viral vectors containing a therapeutic gene, as well as with cDNA for specific proteins, expression of which is desired in a patient. Due to such characteristics, the number of clinical trials based on the use of MSCs increase. These cells have been successfully employed in graft versus host disease (GvHD) treatment, heart regeneration after infarct, cartilage and bone repair, skin wounds healing, neuronal regeneration and many others. Of special importance is their use in the treatment of osteogenesis imperfecta (OI), which appeared to be the only reasonable therapeutic strategy. MSCs seem to represent a future powerful tool in regenerative medicine, therefore they are particularly important in medical research.
A biochar-based medium in the biofiltration system: Removal efficiency, microorganism propagation, and the medium penetration modeling (2016)

The birch biochar can be successfully used in the biofiltration system for propagation of inoculated microorganisms, biodegrading acetone, xylene, and ammonia. At the inlet loading rate of 120 g/m(3)/hr, the highest elimination capacity of xylene was 103 g/m(3)/hr, that of ammonia was 102 g/m(3)/hr, and that of acetone was 97 g/m(3)/hr, respectively. The morphological structure of biochar can be affected by the aggressive air contaminants, causing the change in the medium specific surface area, which is one of the factors controlling the biofilter performance. Although biological effects in biofiltration are typically considered to be more important than physical effects, the former may be more important for compounds with high Henry's Law coefficient values, and the biofilter design should thus provide conditions for better compound absorption.
Self‐cleaning effects of acrylic resin containing fluoridated apatite‐coated titanium dioxide (2013)

Fluoridated apatite-coated titanium dioxide-containing acrylic resin is a clinically suitable material that promotes proper denture hygiene, particularly for elderly persons requiring nursing care or who have a decreased ability to perform normal activities of daily living.
Kinetic-equation approach to nonequilibrium superconductivity (1977)

We have studied thin films driven out of equilibrium under spatially uniform steady-state conditions by thermal phonon injection, microwave and optical irradiations, and quasiparticle tunneling injection. The linearized coupled kinetic equations for the quasiparticle and phonon distributions were solved numerically. Results for the change in the energy distributions of quasiparticles and phonons are given for a variety of nonequilibrium situations. Using these distributions, the changes in the ultrasonic attenuation, electrical conductivity and the superconductor-insulator-superconductor tunneling $I(V)$ characteristic in various nonequilibrium states are obtained.
Adaptive threshold settings in code phase acquisition for the double dwell architecture (2002)

An algorithm for code phase acquisition in direct-sequence spread-spectrum systems is presented and analyzed. The algorithm is a window based double dwell searcher. The algorithm with a moderate window size has shorter acquisition than the immediate verification algorithm has-especially at low SNR. The first-dwell uses a robust method based on a rank filter while the second dwell uses known threshold hypothesis. The code phase acquisition algorithm is compared with both single and double threshold hypothesis algorithms.
Use of the Kohonen Neural Network for Rapid Screening of Ex Vivo Anti-HIV Activity of Styrylquinolines (2002)

Using the Kohonen neural network, the electrostatic potentials on the molecular surfaces of 14 styrylquinoline derivatives were drawn as comparative two-dimensional maps and compared with their known human immunodeficiency virus (HIV)-1 replication blocking potency in cells. A feature of the potential map was discovered to be related with the HIV-1 blocking activity and was used to unmask the activity of further five analogues, previously described but whose cytotoxicity precluded an estimation of their activity, and to predict the activity of 10 new compounds while the experimental data were unknown. The measurements performed later turned out to agree with the predictions.
Development of Novel Phosphine Sulphonate-Based Palladium Catalysts for Ethene Homo- and Co-Polymerisation Reactions with Polar-Functionalised Olefins (2011)

This Ph. D. thesis concerns the investigation of [(P^O)-phosphine sulphonate]Pd(II) complexes with respect to their behaviour in homo- and copolymerisation reactions of ethene and polar functionalised olefins. Different approaches for catalyst design have been successfully performed and the resulting catalysts were tested in polymerisation reactions. The synthesis of non-symmetrically sulphonated phosphines and subsequent phase transfer reactions leads to novel anionic Pd(II) polymerisation catalysts. Additionally the influence of functional groups on the structure of neutral phosphine sulfonate-based Pd(II) complexes in solution and solid state was examined in detail. Polymerisation reactions with these catalysts provided new insights into the structure activity relationship for this class of catalysts.
Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging. (2003)

Intracellular factors that regulate nitric oxide (NO) synthesis represent important targets in tumor progression. Overexpression of dimethylarginine dimethylaminohydrolase (DDAH), which metabolizes the endogenous inhibitors of NO synthesis asymmetric dimethylarginine and N-monomethyl-L-arginine, results in C6 gliomas with enhanced growth rate compared with wild type. To investigate the effects of DDAH on tumor vascular morphogenesis in vivo, we have measured the transverse relaxation rates R(2)* and R(2) in clone D27 gliomas overexpressing DDAH and C6 wild-type gliomas using intrinsic susceptibility magnetic resonance imaging (MRI), sensitive to changes in endogenous [deoxyhemoglobin], and susceptibility contrast-enhanced MRI using the intravascular blood pool contrast agent NC100150, and we compared the results with fluorescence microscopy of the tumor uptake of the perfusion marker Hoechst 33342. The baseline R(2)* was significantly faster in the D27 tumors, consistent with a greater vascular development (P < 0.02, ANOVA). There was no significant difference between the response of the two tumor types to hypercapnia (5% CO(2)/95% air), used as a probe for vascular maturation, or hyperoxia (5% CO(2)/95% O(2)), used as a probe for vascular function. NC100150 increased the R(2)* and R(2) rates of both tumor types and demonstrated a significantly larger blood volume in the D27 tumors (P < 0.02, ANOVA). This correlated with a significantly greater uptake of Hoechst 33342 in the D27 tumors compared with C6 wild-type tumors (P < 0.02, ANOVA). Despite the increased tumor blood volume, the Delta R(2)*/Delta R(2) ratio, an index of microvessel size, showed that the capillaries in the two tumor types were of a similar caliber. The data highlight the potential of susceptibility MRI-derived quantitative end points to noninvasively assess tumor angiogenesis, and in this regard, the use of intravascular blood pool contrast agents such as NC100150 appears very promising. Overexpression of DDAH results in increased neovascularization of C6 gliomas in vivo. The lack of significant difference in hypercapnic/hyperoxic response between the C6 and D27 tumors and the similar vessel caliber are also consistent with a role for DDAH in the initial stages of vasculogenesis.
Commissioning of the tongue-and-groove modelling in treatment planning systems: from static fields to VMAT treatments (2017)

Adequate modelling of the multi-leaf collimator (MLC) by treatment planning systems (TPS) is essential for accurate dose calculations in intensity-modulated radiation-therapy. For this reason modern TPSs incorporate MLC characteristics such as the leaf end curvature, MLC transmission and the tongue-and-groove. However, the modelling of the tongue-and-groove is often neglected during TPS commissioning and it is not known how accurate it is. This study evaluates the dosimetric consequences of the tongue-and-groove effect for two different MLC models using both film dosimetry and ionisation chambers. A set of comprehensive tests are presented that evaluate the ability of TPSs to accurately model this effect in (a) static fields, (b) sliding window beams and (c) VMAT arcs. The tests proposed are useful for the commissioning of TPSs and for the validation of major upgrades. With the ECLIPSE TPS, relevant differences were found between calculations and measurements for beams with dynamic MLCs in the presence of the TG effect, especially for the High Definition MLC, small gap sizes and the 1 mm calculation grid. For this combination, dose differences as high as 10% and 7% were obtained for dynamic MLC gaps of 5 mm and 10 mm, respectively. These differences indicate inadequate modelling of the tongue-and-groove effect, which might not be identified without the proposed tests. In particular, the TPS tended to underestimate the calculated dose, which may require tuning of other configuration parameters in the TPS (such as the dosimetric leaf gap) in order to maximise the agreement between calculations and measurements in clinical plans. In conclusion, a need for better modelling of the MLC by TPSs is demonstrated, one of the relevant aspects being the tongue-and-groove effect. This would improve the accuracy of TPS calculations, especially for plans using small MLC gaps, such as plans with small target volumes or high complexities. Improved modelling of the MLC would also reduce the need for tuning parameters in the TPS, facilitating a more comprehensive configuration and commissioning of TPSs.
FedLoop: Looping on Federated MapReduce (2014)

The challenges of the Big Data era has motivated many organizations to turn towards distributed, large-scale processing platforms to deal with their data. Map Reduce, and its open-source implementation, Hadoop, has grown to be highly popular with its successful programming model for simplified cluster processing. As a result, many organizations deploy their own Map Reduce/Hadoop clusters to store and process large amounts of useful data. This multicluster setting is gradually growing attention. Numerous previous works have researched on how to execute Map Reduce across geographically distributed data in this setting. However, an important class of applications have not been explored for multicluster Map Reduce: iterative computation. In this paper, we propose Fed Loop, a composite system aimed at providing iterative Map Reduce computation for geographically distributed data in multicluster settings. Fed Loop is capable of transparently executing both iterative and non-iterative Map Reduce jobs on either a single cluster or multiple clusters. For our performance evaluation, two well-known iterative algorithms was executed over 4 independent clusters (16 physical nodes in total) using Fed Loop: K-Means and Page Rank. Results helped us discover how different iterative applications may differ in execution efficiency for mutlicluster environments and how iterative multicluster computation systems like Fed Loop can be optimized.
Friction and wear behavior of single-crystal silicon carbide in sliding contact with various metals (1978)

Sliding friction experiments were conducted with single-crystal silicon carbide in contact with various metals. Results indicate the coefficient of friction is related to the relative chemical activity of the metals. The more active the metal, the higher the coefficient of friction. All the metals examined transferred to silicon carbide. The chemical activity of the metal and its shear modulus may play important roles in metal transfer, the form of the wear debris and the surface roughness of the metal wear scar. The more active the metal, and the less resistance to shear, the greater the transfer to silicon carbide and the rougher the wear scar on the surface of the metal. Hexagon shaped cracking and fracturing formed by cleavage of both prismatic and basal planes is observed on the silicon carbide surface.