gebhart/patrepeval huggingface dataset:
Comprehensive Hydromechanical Specific Energy Calculation for Drilling Efficiency (2014)

Over the last few years, different types of bits have been introduced to meet the challenges of steerable as well as rotary steerable systems; and it is imperative that bits be utilized optimally in these systems. As challenges increase with increasing depths, it becomes even more important for one to efficiently utilize the available energy (Robello, S., 2013, “Modeling and Analysis of Drillstring Vibration in Riserless Environment,” ASME J. Energy Res. Technol., 135(1), p. 013101). A new correlation identifying inefficient drilling conditions is presented in this paper. Mechanical specific energy (MSE) has been used to improve drilling rates, with mixed results. Hydro MSE (HMSE), which is introduced here, encompasses hydraulic as well as mechanical energy. HMSE quantifies the amount of energy required to drill a unit volume of rock and remove it from underneath the bit. HMSE includes axial, torsional, and hydraulic energy and is different from MSE because it includes a hydraulic term. The initial MSE correlation (Teale, R., 1965, “The Concept of Specific Energy in Rock Drilling,” Int. J. Rock Mech. Min. Sci., 2, pp. 57–73.) was modified to accommodate the new hydraulic term. This paper attempts to better model downhole drilling by introducing the hydraulic energy term in the MSE correlation by defining it as HMSE. While the majority of the drilling occurs because of the bit, it is a well-known fact that some drilling occurs due to the “jet impact impingement” caused by the drilling fluid as well. Experimental and field data presented in this paper show that HMSE can identify inefficient drilling conditions. The new hydraulic term included in the specific energy correlation is the key to correctly match the amount of energy required to drill and overcome the strength and stresses of formation being drilled. Also, this new term illustrates how much hydraulic energy is needed to drill faster when the mechanical energy (axial and torsional) is increased. The results also show the importance of including the bit hydraulic energy term into any specific energy analysis for drilling optimization. Field results reveal specific patterns for inefficient drilling conditions and also reveal a good correlation between calculated HMSE and the expected requirements for rock removal under existent conditions of stress at the bit face (Mohan, K., and Robello Samuel, F. A., 2009, “Tracking Drilling Efficiency Using Hydro-Mechanical Specific Energy,” SPE/IADC Drilling Conference and Exhibition, March 17–19, Amsterdam, The Netherlands, No. SPE 119421).
A novel optical Bi-Cell with integrated readout circuitry (2003)

In 3D imaging, a laser scanning system needs to be synchronised with the data acquisition electronics. Conventional optical Bi-Cells perform the task but require readout electronics which must be calibrated each time the laser beam intensity changes. In this paper we describe the design of a novel optical Bi-Cell sensor with integrated readout and synchronisation circuitry entirely fabricated in CMOS technology. The processing electronics has been designed to work over two decades of photogenerated current eliminating thus the requirement for calibration over the laser beam intensity changes. A fully differential architecture has been implemented to make the circuit less sensitive to temperature and power supply variations. Experimental results will also be presented.
Nucleic acid-induced self-assembly of a platinum(ii) terpyridyl complex: detection of G-quadruplex formation and nuclease activity (2009)

A simple "proof-of-principle" concept for the monitoring of G-quadruplex formation and nuclease activity based on the unique self-assembly properties of a platinum(II) terpyridyl complex, has been demonstrated.
Fenebrutinib in H1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial (2021)

Bruton's tyrosine kinase (BTK) is crucial for FcεRI-mediated mast cell activation and essential for autoantibody production by B cells in chronic spontaneous urticaria (CSU). Fenebrutinib, an orally administered, potent, highly selective, reversible BTK inhibitor, may be effective in CSU. This double-blind, placebo-controlled, phase 2 trial (EudraCT ID 2016-004624-35 ) randomized 93 adults with antihistamine-refractory CSU to 50 mg daily, 150 mg daily and 200 mg twice daily of fenebrutinib or placebo for 8 weeks. The primary end point was change from baseline in urticaria activity score over 7 d (UAS7) at week 8. Secondary end points were the change from baseline in UAS7 at week 4 and the proportion of patients well-controlled (UAS7 ≤ 6) at week 8. Fenebrutinib efficacy in patients with type IIb autoimmunity and effects on IgG-anti-FcεRI were exploratory end points. Safety was also evaluated. The primary end point was met, with dose-dependent improvements in UAS7 at week 8 occurring at 200 mg twice daily and 150 mg daily, but not at 50 mg daily of fenebrutinib versus placebo. Asymptomatic, reversible grade 2 and 3 liver transaminase elevations occurred in the fenebrutinib 150 mg daily and 200 mg twice daily groups (2 patients each). Fenebrutinib diminished disease activity in patients with antihistamine-refractory CSU, including more patients with refractory type IIb autoimmunity. These results support the potential use of BTK inhibition in antihistamine-refractory CSU.
Self-Healing Materials Systems: Overview of Major Approaches and Recent Developed Technologies (2012)

The development of self-healing materials is now being considered for real engineering applications. Over the past few decades, there has been a huge interest in materials that can self-heal, as this property can increase materials lifetime, reduce replacement costs, and improve product safety. Self-healing systems can be made from a variety of polymers and metallic materials. This paper reviews the main technologies currently being developed, particularly on the thermosetting composite polymeric systems. An overview of various self-healing concepts over the past decade is then presented. Finally, a perspective on future self-healing approaches using this biomimetic technique is offered. The intention is to stimulate debate and reinforce the importance of a multidisciplinary approach in this exciting field.
New opportunities in science, materials, and biological systems in the low-gravity (magnetic levitation) environment (invited) (2000)

We discuss new opportunities that present themselves with the advent of very high magnetic field resistive magnets with appreciable central bore access. A detailed description of the parameters of the magnetic force environment for the case of diamagnetic materials in a water-cooled Bitter-type resistive magnet is provided for the reader who may have an interest in low-gravity experiments. We discuss emerging research activities involving novel uses of magnetic forces in high field resistive magnets at the National High Magnetic Field Laboratory. Particular attention is given to the area of diamagnetic materials that allow a low or “zero” gravity state, i.e., magnetic levitation. These include studies involving plant growth, protein crystallization, and dynamics of single particles and granular materials. In the latter case, unique aspects of the magnetic force environment allow low gravity experiments on particulates that cannot be performed on the Space Shuttle due to the lack of a weak confining potential in space.
HMGB1, a Novel Cytokine-Like Mediator Linking Acute Neuronal Death and Delayed Neuroinflammation in the Postischemic Brain (2006)

Cerebral ischemic injury proceeds with excitotoxicity-induced acute neuronal death in the ischemic core and with delayed damage processes in the penumbra. However, knowledge concerning the direct mediators that connect these two processes is limited. Here, we demonstrate that high-mobility group box 1 (HMGB1), a nonhistone DNA-binding protein, is massively released into the extracellular space immediately after ischemic insult and that it subsequently induces neuroinflammation in the postischemic brain. Short hairpin (sh)RNA-mediated HMGB1 downregulation in the postischemic brain suppressed infarct size, microglia activation, and proinflammatory marker induction, indicating that HMGB1 plays a crucial role in the inflammatory process. The proinflammatory cytokine-like function of extracellular HMGB1 was further verified in primary cortical cultures and microglial cultures. HMGB1 was found to accumulate in NMDA-treated primary cortical culture media, and supernatants collected from these cultures were found to trigger microglia activation, the hallmark of brain inflammation. Moreover, treatment with recombinant HMGB1 also induced microglial activation, but HMGB1-depleted supernatant produced by anti-HMGB1 antibody treatment or by HMGB1 shRNA expression did not, thus demonstrating the essential role of HMGB1 in microglial activation. Together, these results indicate that HMGB1 functions as a novel proinflammatory cytokine-like factor that connects excitotoxicity-induced acute damage processes and delayed inflammatory processes in the postischemic brain.
Direct Measurement of Microporosity and Molecular Accessibility in Stöber Spheres by Adsorption Isotherms (2018)

The microporous nature of monodisperse Stöber silica spheres is demonstrated in the literature, although usually via indirect evidence. Contradictorily, there also exist numerous reports of nonporosity based on conventional N2 adsorption isotherms, leading to a confusing scenario and questioning the evaluation methodology. Thus, there is the strong need of straight measure of microporosity in Stöber spheres, at best by available adsorption techniques, which must be further directly confronted with the standard nitrogen method. Here, for the first time, microporosity detection by N2 and CO2 adsorption is compared in Stöber spheres. We demonstrate that CO2 isotherms at 273 K allow direct detection and quantification of the microporosity (about 0.1 cm3/g in our samples), while N2 at 77 K cannot probe adequately the internal volume. We also show that a large amount of water fills the micropores under usual ambient conditions, also revealing the presence of small mesoporosity. Thus, the porous nature of Stöber spheres is investigated by a simple combination of adsorption isotherms, and the different accessibility of N2, CO2, and H2O molecules is discussed. We emphasize the inadequacy of standard N2 isotherms for micropore detection in Stöber silica, as the access of nitrogen molecules at cryogenic temperatures is kinetically restricted and may lead to erroneous conclusions. Instead, we propose CO2 isotherms as a simple and direct means for evaluation of microporosity.
Dimensional Reduction: A Design Tool for New Radiation Detection Materials (2011)

Semiconductor materials for efficient hard radiation detection are identified by combining a powerful chemical concept called dimensional reduction and precise theoretical electronic structure calculations. After more than 50 years of research and development in the field, this constitutes a significant step forward in the search for new detector materials. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Asymmetric Transfer Hydrogenation of Ketones with Bifunctional Transition Metal-Based Molecular Catalysts (2007)

Recent development of conceptually new chiral bifunctional transition metal based catalysts for asymmetric reductive transformations is described. The chiral bifunctional molecular catalyst promoted reduction is now realized to be a powerful tool to access chiral compounds in organic synthetic procedures in both academia and industry. Based on structural investigation of the actual catalyst and its intermediates and a deep understanding of the reaction mechanism, this asymmetric reduction system can be widely used to produce valuable chiral alcohols and is now is applicable to commercial scale production.
Syntrophothermus lipocalidus gen. nov., sp. nov., a novel thermophilic, syntrophic, fatty-acid-oxidizing anaerobe which utilizes isobutyrate. (2000)

A new anaerobic, thermophilic, syntrophic, fatty-acid-oxidizing bacterium designated strain TGB-C1T was isolated from granular sludge in a thermophilic upflow anaerobic sludge blanket (UASB) reactor. The cells were slightly curved rods and were weakly motile. Spore formation was not observed. The optimal temperature for growth was around 55 degrees C and growth occurred in the range 45 to 60 degrees C. The pH range for growth was 5.8-7.5, and the optimum pH was 6.5-7.0. Crotonate was the only substrate that allowed the strain to grow in pure culture. However, in co-culture with the thermophilic, hydrogenotrophic Methanobacterium thermoautotrophicum strain delta H, the isolate could syntrophically oxidize saturated fatty acids with 4-10 carbon atoms, including isobutyrate. During the degradation of isobutyrate by the co-culture, isobutyrate was isomerized to butyrate, which was then oxidized. The strain was not able to utilize sulfate, sulfite, thiosulfate, nitrate, fumarate or Fe(III) as electron acceptor. The DNA base composition was 51.0 mol%. 16S rDNA sequence analysis revealed that the strain belongs to the family Syntrophomonadaceae, but it was only distantly related to other known species of beta-oxidizing syntrophs. Hence, the name Syntrophothermus lipocalidus is proposed for TGB-C1T as a new species of a new genus.
Opioids in neuropathic pain: clues from animal studies (2004)

For many years the clinical consensus was that opioids were ineffective in neuropathic pain. However this view is changing and here we discuss the mechanisms of opioid analgesia in terms of the changes that can occur in preclinical models of nerve injury. We argue that opioid mechanisms can be perturbed by neuropathy but in most cases these negative influences can be overcome by dose-escalation.
Heterogeneous modeling for automotive electronic control units using a CASE-tool integration platform (2005)

Up to 70 electronic control units (ECU's) serve for safety and comfort functions in a car. Communicating over different bus systems most ECU's perform close loop control functions and reactive functions and have to fulfill hard real time constraints. Some ECU's controlling on board entertainment/office systems are software intensive, incorporating millions of lines of code. The challenge for the design of those distributed and networked control units is to define all requirements and constraints, understand and analyze those manifold interactions between the control units, the car and the environment (driver, road, weather) in normal as well as stress situations (crash). To design within a development process which is concurrent and distributed between the automotive manufacturer and several suppliers requires a well understood life-cycle model, a strictly controlled design methodology and using computer aided engineering tools to its largest extent. We have developed the CASE-tool integration platform "generalstore" to support the design of automotive ECU's, however, generalstore is also used for the design of industrial automation systems and biomedical systems.
Optimal sequencing of treatments for patients with myelodysplastic syndromes (2009)

We review these recent advances in this paper.
Las Vegas Academy Jazz Band III: A Celebration of Black History Month (2012)

Program listing performers and works performed.
Relativistic electron populations in Cassiopeia A (1991)

Spectral index variations are observed in the radio brightness distribution in the supernova remnant Cassiopeia A, between observing wavelengths of 20 and 6 cm. Reliable variations are seen over a range of -0.64 to -0.92, with steeper spectra typically associated with compact features such as the 'bow shocks' and flatter spectra with the bright radio ring. The spatial scales over which significant variations are detected range from about 11 arcsec to greater than 80 arcsec. These results indicate a direct link between the dynamics of the remnant and the relativistic particle energy distributions. Building on previously suggested dynamical pictures, it is suggested that the bow shocks are caused by moderately dense clumps of ejecta newly encountering the shocked ISM. It is found that models based on first-order Fermi acceleration in the test particle limit are unable to explain, concurrently, the steep spectral indices and the high synchrotron emissivities observed in Cas A. Thus, consideration of other types of processes, such as acceleration in cosmic-ray-mediated shocks and turbulent acceleration with secularly increasing B fields, is required.
A Programming Model for Internetworked Things (2019)

The Internet of Things (IoT) emerges as a system paradigm that encompasses a wide spectrum of technologies and protocols related to Internetworking, services computing, and device connectivity. The main objective is to achieve an environment whereby physical devices and everyday objects can communicate and interact with each other over the Internet. The Internet of Things is heralded as the next generation Internet, and introduces significant opportunities for novel applications in many different domains. What is missing right now is a programming model whereby developers as well as end-users can specify any addressable resource at a higher level of abstraction, and consequently utilize these abstractions to define compositions, or scripts, among resources that allow for the customizable exchange of data among the resources, the evaluation of conditions based on exchanged data, and the enactment of actions provided that specific events occur and specific conditions are met.\nIn this thesis, we investigate the problem of designing a programming model for composing resource or "things", with applications in the IoT domain, and implement a proof of concept prototype in order to evaluate the feasibility of such a programming model. More specifically, this thesis attacks the problem of devising an IoT programming model from three directions. The first direction is the design of a Meta-Object Facility meta-model, that allows for URI addressable entities to be specified at a higher level of abstraction. Such a meta-model can be considered as domain specific language that allows for the denotation of \\emph{types} of entities (resources) in different application domains. The second direction is the design of an actionable composition model for IoT devices and other URI addressable resources. In this respect, this thesis investigates the use of the Event-Condition-Action paradigm as a basis of a runtime environment whereby action models can be enacted once events occur and condition models are fulfilled. A resource composition model also allows for resources to exchange data through input and output plugs implemented on top of the OPC UA publish subscribe middleware. The third direction deals with the design of a layered architecture that allows for scalability, robustness, security, and fault tolerance to be considered. Such an architecture takes advantage of a publish subscribe framework and utilizes proxies and facades to efficiently connect with third party components.
Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results (2016)

The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. <i>Methods</i>. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. <i>Results.</i> At 18 months of follow-up, some patients showed "enticing" improvements on some exploratory efficacy measures, although a significant benefit was not observed for any measure across the entire group. Neither the progression of disability nor relapses were observed in any cases. In four patients, we found new gadolinium+ (Gd+) lesions on MRI. Our results indicate that ASC therapy is safe and does not produce any substantial side effects. Disease progression-free survival (PFS) of 18 months was seen in all patients with RRMS and SPMS. In these patients, EDSS scores did not progress above baseline scores. Gd-enhancing lesions were observed in two cases with RRMS, but these patients did not exhibit changes in EDSS score. <i>Conclusion</i>. Intrathecal treatment with ASCs is an attractive form of therapy for patients with MS but should be reserved for cases with aggressive disease progression, for cases that are still in the inflammatory phase, and for the malignant form.
S100A8 and S100A9 Mediate Endotoxin-Induced Cardiomyocyte Dysfunction via the Receptor for Advanced Glycation End Products (2008)

Cardiovascular dysfunction as a result of sepsis is the leading cause of death in the critically ill. Cardiomyocytes respond to infectious pathogens with a Toll-like receptor-initiated proinflammatory response in conjunction with a decrease in contractility, although the downstream events linking Toll-like receptor activation and reduced cardiac contractility remain to be elucidated. Using microarray analysis of cardiac tissue exposed to systemic lipopolysaccharide (LPS), we discovered that 2 small calcium-regulating proteins (S100A8 and S100A9) are highly upregulated. HL-1 cardiomyocytes, isolated primary cardiomyocytes, and live mice were exposed to LPS, whereas beating HL-1 cells had S100A8 and S100A9 overexpressed and their calcium flux quantified. Using in vivo microbubble technology, we delivered S100A8 and S100A9 to normal mouse hearts; using the same technology, we inhibited S100A9 production in mouse hearts and subsequently exposed them to LPS. Coimmunoprecipitation of S100A8 and S100A9 identified interaction with RAGE (the receptor for advanced glycation end products), the cardiac function and postreceptor signaling of which were investigated. HL-1 cardiomyocytes, isolated primary cardiomyocytes, and whole hearts exposed to LPS have large increases in S100A8 and S100A9. Cardiac overexpression of S100A8 and S100A9 led to a RAGE-dependent decrease in calcium flux and, in the intact mouse, to a decreased cardiac ejection fraction, whereas knockdown of S100A9 attenuated LPS-induced cardiac dysfunction. Cardiomyocytes exposed to LPS express S100A8 and S100A9, leading to a RAGE-mediated decrease in cardiomyocyte contractility. This finding provides a novel mechanistic link between circulating pathogen-associated molecular products and subsequent cardiac dysfunction.