gebhart/patrepeval huggingface dataset:
Modeling Uncertainty in Clinical Diagnosis Using Fuzzy Logic (2005)

This paper describes a fuzzy approach to computer-aided medical diagnosis in a clinical context. It introduces a formal view of diagnosis in clinical settings and shows the relevance and possible uses of fuzzy cognitive maps. A constraint satisfaction method is introduced that uses the temporal uncertainty in symptom durations that may occur with particular diseases. The method results in an estimate of the stage of the disease if the temporal constraints of the disease in relation to the occurrence of the symptoms are satisfied. A lightweight fuzzy process is described and evaluated in the context of diagnosis of two confusable diseases. The process is based on the idea of an incremental simple additive model for fuzzy sets supporting and negating particular diseases. These are combined to produce an index of support for a particular disease. The process is developed to allow fuzzy symptom information on the intensity and duration of symptoms. Results are presented showing the effectiveness of the method for supporting differential diagnosis.
Oilbody Proteins in Microspore-Derived Embryos of <i>Brassica napus</i> (1991)

A number of treatments were tested for their ability to affect the synthesis of oilbody proteins in microspore-derived embryos of rapeseed (Brassica napus). Synthesis of the oilbody proteins was determined by [(35)S]methionine incorporation in vivo and sodium dodecyl sulfate-polyacrylamide gel electrophoresis of washed oilbody fractions. Oilbody proteins of approximately 19, 23, and 32 kilodaltons were found to be prominent. These proteins showed differential patterns of regulation. The 19 and 23 kilodalton proteins (oleosins) were greatly enhanced by treatments with abscisic acid, jasmonic acid, and osmotic stress imposed using sorbitol (12.5%). Synthesis of the 32 kilodalton protein was inhibited by abscisic acid and by sorbitol (12.5%), but unaffected by jasmonates. The strong promotion of synthesis of the 19 and 23 kilodalton oilbody proteins appeared to be specific as they are not seen with gibberellic acid treatment or with a stress such as heat shock. Time course experiments revealed that the abscisic acid stimulation of oleosin synthesis is quite rapid (less than 2 hours), reaching a maximum at 6 to 8 hours. The response of the oleosins to abscisic acid is found in all stages of embryogenesis, with a major increase in synthetic rates even in globular embryos on abscisic acid treatment. This suggests that these proteins may accumulate much earlier in embryogenesis than has previously been believed. The 32 kilodalton oilbody-associated protein appears different from the oleosins in several ways, including its distinct pattern of regulation and its unique property, among the oilbody proteins, of undergoing phosphorylation.
A 5-Gb/s 66 dB CMOS Variable-Gain Amplifier With Reconfigurable DC-Offset Cancellation for Multi-Standard Applications (2018)

This paper proposes a variable gain amplifier (VGA) with reconfigurable DC-offset cancellation (DCOC) for multi-standard applications. In this design, a cell-based design method and some bandwidth extension technologies are adopted to achieve a high data rate and a wide gain control range simultaneously. In addition, the DCOC having a tunable lower-cutoff frequency can make an optimum compromise between BER and SNR according to the specified baseband standard. The measurements show that the VGA achieves a gain control range from -6 dB to 60 dB, a bandwidth beyond 3 GHz, and a tunable lower-cutoff frequency from 0 to 300 kHz. When entering a 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">23</sup> -1 pseudo-random bit sequence signal at 5 Gb/s, the VGA consumes 17 mW from a 1.2-V supply and the output data peak-to-peak jitter is less than 40 ps. The VGA is fabricated in a 90-nm CMOS process with a chip size (including all pads) of 0.52 × 0.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Thionate versus Oxon: Comparison of Stability, Uptake, and Cell Toxicity of (<sup>14</sup>CH<sub>3</sub>O)<sub>2</sub>-Labeled Methyl Parathion and Methyl Paraoxon with SH-SY5Y Cells (2010)

The stability, hydrolysis, and uptake of the organophosphates methyl parathion and methyl paraoxon were investigated in SH-SY5Y cells. The stabilities of ((14)CH(3)O)(2)-methyl parathion ((14)C-MPS) and ((14)CH(3)O)(2)-methyl paraoxon ((14)C-MPO) at 1 microM in culture media had similar half-lives of 91.7 and 101.9 h, respectively. However, 100 microM MPO caused >95% cytotoxicity at 24 h, whereas 100 microM MPS caused 4-5% cytotoxicity at 24 h ( approximately 60% cytotoxicity at 48 h). Greater radioactivity was detected inside cells treated with MPO as compared to MPS, although >80% of the total MPO uptake was primarily dimethyl phosphate (DMP). Maximum uptake was reached after 48 h of (14)C-MPS or (14)C-MPO exposure with total uptakes of 1.19 and 1.76 nM/10(6) cells for MPS and MPO, respectively. The amounts of MPS and MPO detected in the cytosol after 48 h of exposure time were 0.54 and 0.37 nM/10(6) cells, respectively.
Reconstructing Stimuli from the Spike Times of Leaky Integrate and Fire Neurons (2011)

Reconstructing stimuli from the spike trains of neurons is an important approach for understanding the neural code. One of the difficulties associated with this task is that signals which are varying continuously in time are encoded into sequences of discrete events or spikes. An important problem is to determine how much information about the continuously varying stimulus can be extracted from the time-points at which spikes were observed, especially if these time-points are subject to some sort of randomness. For the special case of spike trains generated by leaky integrate and fire neurons, noise can be introduced by allowing variations in the threshold every time a spike is released. A simple decoding algorithm previously derived for the noiseless case can be extended to the stochastic case, but turns out to be biased. Here, we review a solution to this problem, by presenting a simple yet efficient algorithm which greatly reduces the bias, and therefore leads to better decoding performance in the stochastic case.
Enablers for embedding big data solutions in smart factories: an empirical investigation (2019)

This study provides insight into the enablers that assist organizations in implementing big data solutions in their smart factory development, as well as the interrelationships between these enablers from an information system (IS) perspective. The research followed an inductive qualitative approach. Twenty-two in-depth semi-structured interviews were conducted with experienced consultants and IT managers from SAP Consultancy Company, and general managers and engineers from Xiamen Intretech Inc., a leading manufacturing company in adopting big data solutions in smart factory. Following thematic analysis approach, three sets of enablers including organization, technology and external environment were identified together with the interrelationships between them. This paper extends the current understanding of smart factory and big data solutions in information system research through offering an empirical investigation of different enablers in this context. The findings also provide recommendations for practitioners to increase the possibilities of success when implementing big data solutions in smart factory context.
Genome Sequencing and Comparative Genomics of the Broad Host-Range Pathogen Rhizoctonia solani AG8 (2014)

Rhizoctonia solani is a soil-borne basidiomycete fungus with a necrotrophic lifestyle which is classified into fourteen reproductively incompatible anastomosis groups (AGs). One of these, AG8, is a devastating pathogen causing bare patch of cereals, brassicas and legumes. R. solani is a multinucleate heterokaryon containing significant heterozygosity within a single cell. This complexity posed significant challenges for the assembly of its genome. We present a high quality genome assembly of R. solani AG8 and a manually curated set of 13,964 genes supported by RNA-seq. The AG8 genome assembly used novel methods to produce a haploid representation of its heterokaryotic state. The whole-genomes of AG8, the rice pathogen AG1-IA and the potato pathogen AG3 were observed to be syntenic and co-linear. Genes and functions putatively relevant to pathogenicity were highlighted by comparing AG8 to known pathogenicity genes, orthology databases spanning 197 phytopathogenic taxa and AG1-IA. We also observed SNP-level "hypermutation" of CpG dinucleotides to TpG between AG8 nuclei, with similarities to repeat-induced point mutation (RIP). Interestingly, gene-coding regions were widely affected along with repetitive DNA, which has not been previously observed for RIP in mononuclear fungi of the Pezizomycotina. The rate of heterozygous SNP mutations within this single isolate of AG8 was observed to be higher than SNP mutation rates observed across populations of most fungal species compared. Comparative analyses were combined to predict biological processes relevant to AG8 and 308 proteins with effector-like characteristics, forming a valuable resource for further study of this pathosystem. Predicted effector-like proteins had elevated levels of non-synonymous point mutations relative to synonymous mutations (dN/dS), suggesting that they may be under diversifying selection pressures. In addition, the distant relationship to sequenced necrotrophs of the Ascomycota suggests the R. solani genome sequence may prove to be a useful resource in future comparative analysis of plant pathogens.
Engineering Tumors: A Tissue Engineering Perspective in Cancer Biology (2010)

There is increasing recognition that three-dimensional (3D) tissue culture technologies have many uses within the biomedical sciences beyond the scope of regenerative medicine. One such use is in the field of cancer biology, where a 3D tumor model that accurately recreates the in vivo tumor phenotype would be a valuable tool for studying tumor biology and would allow better preclinical evaluation of anticancer drug candidates. The most widely used model involves small cellular aggregates, termed spheroids, which have been used by cancer biologists for decades and have consistently shown the superiority of 3D tissue culture over standard two-dimensional monolayer culture for mimicking the tumor behavior and drug resistance encountered in vivo. Currently, several research groups have begun to adapt more advanced 3D culture techniques from the tissue engineering field to create a more clinically accurate ex vivo model of tumor biology.
Refractory celiac disease (2015)

Refractory celiac disease (RCD) affects patients who have failed to heal after 6-12 months of a strict gluten-free diet (GFD) and when other causes of symptoms (including malignancy) have been ruled out. It may also occur in patients who previously had responded to a long-term GFD. RCD may be categorized as RCD1 (normal immunophenotype) and RCD2 (aberrant immunophenotype). RCD1 usually responds to a continued GFD, nutritional support, and therapeutic agents such as corticosteroids. In contrast, clinical response in RCD2 is incomplete and prognosis is often poor. RCD (particularly RCD2) is associated with serious complications, such as ulcerative jejunitis and enteropathy-associated T-cell lymphoma (EATL). Strict clinical and laboratory criteria should be used to diagnose RCD and specialized tests for aberrancy and clonality should be interpreted in the context of their sensitivity and specificity. Adequate nutritional support and anti-inflammatory treatment may even allow patients with RCD2 to attain a clinical remission.
Investigations into NOx Aftertreatment with Urea SCR for Light-Duty Diesel Vehicles (2001)

<div class="htmlview paragraph">Future US emissions limits are likely to mean a sophisticated nitrogen oxide (NOx) reduction technique is required for all vehicles with a diesel engine, which is likely to be either NOx trap or selective catalytic reduction (SCR) technology. To investigate the potential of SCR for NOx reduction on a light duty vehicle, a current model vehicle (EUII M1 calibration), of inertia weight 1810 kg, was equipped with an urea-based SCR injection system and non-vanadium, non-zeolitic SCR catalysts. To deal with carbon monoxide (CO), hydrocarbon (HC) and volatile organic fraction (VOF), a diesel oxidation catalyst was also incorporated into the system for most tests. Investigations into the effect of placing the oxidation catalyst at different positions in the system, changing the volume of the SCR catalysts, increasing system temperature through road load changes, varying the SCR catalyst composition, and changing the urea injection calibration are discussed. A NOx conversion of 73% over the FTP cycle (0.260 g/mile tailpipe) was achieved with the best system.</div>
Viscous damping of microresonators for gas composition analysis (2006)

The damping effect of various gas environments on a silicon, lateral microresonator implemented with piezoresistive detection is investigated in this study. The resonant frequency of the cantilever shifts due to viscous damping by an amount that is directly determined by the molar mass of the gas, thereby providing a method to determine the composition of the gas environment. In addition, the microresonator demonstrates the ability to perform CO2 composition analysis using this nonreaction based detection method. The advantages of this gas analysis method are that it is simple, repeatable, reversible and not limited to reactive gases.
Methanol Poisoning (1991)

Methanol ingestion can lead to visual impairment, central nervous system dysfunction, or death. The extent of ocular involvement has been difficult to determine because the toxicity is restricted to humans and nonhuman primates due to species differences in methanol metabolism. A rodent model of methanol toxicity recently developed by us was used to evaluate retinal dysfunction in methanol poisoning. Formic acidemia and visual toxic reactions developed in methanol-intoxicated rats. Electroretinographic analysis indicated a significant early deficit in b-wave amplitude followed by a temporally delayed, lesser reduction in a-wave amplitude. Histologic evaluation of the eyes 60 hours after methanol administration revealed generalized retinal edema and vacuolation in the photoreceptors and retinal pigment epithelium. Ultrastructural examination showed swelling and disruption of the mitochondria in photoreceptor inner segments, optic nerve, and the retinal pigment epithelium. These studies document direct retinal involvement in this nonprimate model of methanol toxicity.
45 degree linearly polarised post-wall waveguide-fed parallel-plate slot arrays (2000)

A new configurafion of three slots is proposed to radiate a 45° linearly polarised wave in post-wall waveguide-fed parallel plate slot arrays. The configuration consists of one radiating slot tilted to give the desired polarisation and two parallel λ/2-spaced reflection-cancelling slots without radiation in the boresight. A uniform aperture field is designed in a 76 GHz antenna. A good cross-polarisation level below –28 dB is achieved in the boresight. A gain of 29.8 dBi is obtained with 46.4% efficiency in a 5 cm-square antenna.
Comorbidity in psoriatic arthritis and rheumatoid arthritis (2018)

High rates of comorbidity were found in ARAD participants with PsA. The prevalence of depression, cardiovascular risk factors and other comorbidities were higher in PsA than RA participants in our Australian cohort.
A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors. (1977)

Thymocytes cultured with irradiated, allogeneic stimulator cells yield no cytotoxic effector cells after a period in culture. If, however, a population of irradiated spleen cells syngeneic to the responder cells are added to these cultures, cytotoxicity is generated. The helper activity present in the irradiated syngeneic spleen cells was found to be mediated by a cell bearing theta antigens. Furthermore, it was found to be antigen specific; helper cells which were tolerant of the stimulator cell antigens were unable to help the thymocyte responder cells, although these tolerant cells did contain helpers specific for a third party antigen. These experiments are consistent with a requirement for associative recognition of linked determinants in the induction of killer precursors which is thus strictly analogous to the induction of B-cell precursors via collaboration with helper T cells. In more extensive studies, it was found that histoincompatible helper cells (H-2b, H-2p, H-2q) were able to help a cytotoxic T cell (H-2k) response to a third party stimulator cell antigen (H-2d); that is, the helper T cells which interact with cytotoxic T-cell precursors are not strain specific. It seems likely that the histocompatible helper cells induce killer precursors in an antigen-specific cooperation event similar or identical to normal syngeneic cooperation.
Navimation : exploring time, space & motion in the design of screen-based interfaces (2010)

Open Access - This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
New antenna topologies for 5G communication systems (2016)

This paper presents new antenna topologies for 5G communication systems. The objective is the study of low losses distribution network technologies and the radiating elements for low profile antennas for 5G applications. Different technologies are considered as PCB technology, LTCC technology and metallized 3D printing in terms of design procedures, transmission losses and manufacturing processes in order to contribute to these types of technologies. Different designs and prototypes are done to validate these antennas for 5G communication systems.
The hepatoprotective activity of Fenugreek seeds' extract against carbon tetrachloride induced liver toxicity in rats (2011)

The liver subjected to a number of disorders caused by chemicals namely as hepatotoxicity. carbon tetrachloride (CCl4) the most wildly used in inductionof liver injury as a hepatotoxic model for scientific researches. The role of plants in treatment and prevention of chemical-induced liver damage, was extensively studied. Accordingly, this study was designed to evaluate the hepatoprotective effect of the aqueous solution of the ethanolic extract of Fenugreek seeds (FGS) against CCl4 induced liver damage in rats. From analysis of results, the extract of FGS showed highly hepatoprotective effect against CCl4 induced-necrosis with less effect against fatty changes, this could be due to the antioxidant action of the active constituents in the extract that counteract and scavenge the intermediates free radicals of CCl4 that generating during lipid peroxidation, which is the main cause of necrotic damage, while limitations of these constituents to inhibit the intermediates involved during fatty changes which is unrelated to the oxidative stress. These results make the FGS as a goodcandidate to be used against drug induced hepatotoxicity.
Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel (2012)

Increasing evidence supports a critical role of T cells in neurodegeneration associated with acute and subacute brain inflammatory disorders. Granzyme B (GrB), released by activated T cells, is a cytotoxic proteinase which may induce perforin-independent neurotoxicity. Here, we studied the mechanism of perforin-independent GrB toxicity by treating primary cultured human neuronal cells with recombinant GrB. GrBactivated the protease-activated receptor (PAR)-1 receptor on the neuronal cell surface leading to decreased intracellular cyclic AMP levels. This was followed by increased expression and translocation of the voltage gated potassium channel, Kv1.3 to the neuronal cell membrane. Similar expression of Kv1.3 was also seen in neurons of the cerebral cortex adjacent to active inflammatory lesions in patients with multiple sclerosis. Kv1.3 expression was followed by activation of Notch-1 resulting in neurotoxicity. Blocking PAR-1, Kv1.3 or Notch-1 activation using specific pharmacological inhibitors or siRNAs prevented GrB-induced neurotoxicity. Furthermore, clofazimine protected against GrB-induced neurotoxicity in rat hippocampus, in vivo. These observations indicate that GrB released from T cells induced neurotoxicity by interacting with the membrane bound Gi-coupled PAR-1 receptor and subsequently activated Kv1.3 and Notch-1. These pathways provide novel targets to treat T cell-mediated neuroinflammatory disorders. Kv1.3 is of particular interest since it is expressed on the cell surface, only under pathological circumstances, and early in the cascade of events making it an attractive therapeutic target.
CBRAIN: a web-based, distributed computing platform for collaborative neuroimaging research (2014)

The Canadian Brain Imaging Research Platform (CBRAIN) is a web-based collaborative research platform developed in response to the challenges raised by data-heavy, compute-intensive neuroimaging research. CBRAIN offers transparent access to remote data sources, distributed computing sites, and an array of processing and visualization tools within a controlled, secure environment. Its web interface is accessible through any modern browser and uses graphical interface idioms to reduce the technical expertise required to perform large-scale computational analyses. CBRAIN's flexible meta-scheduling has allowed the incorporation of a wide range of heterogeneous computing sites, currently including nine national research High Performance Computing (HPC) centers in Canada, one in Korea, one in Germany, and several local research servers. CBRAIN leverages remote computing cycles and facilitates resource-interoperability in a transparent manner for the end-user. Compared with typical grid solutions available, our architecture was designed to be easily extendable and deployed on existing remote computing sites with no tool modification, administrative intervention, or special software/hardware configuration. As October 2013, CBRAIN serves over 200 users spread across 53 cities in 17 countries. The platform is built as a generic framework that can accept data and analysis tools from any discipline. However, its current focus is primarily on neuroimaging research and studies of neurological diseases such as Autism, Parkinson's and Alzheimer's diseases, Multiple Sclerosis as well as on normal brain structure and development. This technical report presents the CBRAIN Platform, its current deployment and usage and future direction.