gebhart/patrepeval huggingface dataset:
Production of 100% Cellulose Nanofibril Objects Using the Molded Cellulose Process: A Feasibility Study (2020)

High barrier and mechanically resistant three-dimensional (3D) cellulosic objects were produced using cellulose nanofibrils (CNF) and the molded cellulose process. The main objective is to improve properties of objects made by molding conventional papermaking fibers such as egg box. This well-known process, currently used for the production of low-end cellulose packaging, was simulated using 3D-printed polycarbonate porous molds, dewatering, and heat compression stages. CNF produced by twin screw extrusion, which possess good barrier properties and transparency, were used as the base material, and different methods were used to form the cellulosic mats. Different drying techniques were tested in order to produce a transparent object and minimize the shrinkage of CNF upon drying, that is, oven-drying, thermo-pressing, microwave-drying, freeze-drying, or a combination. CNF cellulosic mats were easily formed, but due to the important shrinkage of CNF, none of the mat formation or drying techniques yielded transparent and dimensionally stable 3D objects.
Obesity and Headache: Part <scp>II</scp> – Potential Mechanism and Treatment Considerations (2014)

Obesity and headache are both associated with a substantial personal and societal impact, and epidemiologic studies have consistently identified a positive association between obesity and headache in general, as well as obesity and migraine specifically (see part I). In the current manuscript, we will discuss the potential mechanisms for the migraine-obesity association, with a focus on the central and peripheral pathophysiological pathways which overlap between migraine and those modulating the drive to feed. We then discuss surgical, behavioral, and pharmacological treatment considerations for overweight and obese migraineurs as well as for those with idiopathic intracranial hypertension. We close by briefly discussing where future research may be headed in light of this data.
P-227 (2012)

Warner, Marcella; Mocarelli, Paolo; Brambilla, Paolo; Wesselink, Amelia; Needham, Larry; Patterson, Donald G; Eskenazi, Brenda Author Information
Effects of Secondary Flow Caused by a Curved Channel on Plasma Protein Adsorption to Artificial Surfaces (1998)

The effects of secondary flow induced by a curved channel on fibrinogen deposition and replacement on a glass surface were studied. Platelet adhesion to surface-bound fibrinogen was also studied to indicate how secondary flow may affect thrombogenesis on artificial surfaces. A saline pre-wetted channel with straight and curved sections was exposed to flowing plasma at a Reynolds number of 28.6. Results show that fibrinogen deposited on the surface at a shear rate of 175 s-1 was replaced faster in regions of secondary flow (Dean numbers from 11 to 19) than in adjacent regions of shear flow. Platelets adhered only to those surfaces where fibrinogen had been detected.
Synthesis of New Water‐Soluble DNA‐Binding Subunits for Analogues of the Cytotoxic Antibiotic CC‐1065 and Their Prodrugs (2006)

Abstract Novel water‐soluble indole‐2‐carboxylic acid derivatives ( 7 , 13 , 21 and 25 ) bearing a substituent with a tertiary amino functionality at C‐5 have been prepared. These new DNA‐binding subunits can be used for the synthesis of new analogues of the cytotoxic antibiotic CC‐1065 and their corresponding prodrugs for antibody‐directed enzyme prodrug therapy (ADEPT) within a selective treatment of cancer.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Models Supporting Trajectory Planning in Autonomous Vehicles (2018)

Autonomous vehicles have the potential to drastically improve the safety, efficiency and cost of transportation. Instead of a driver, an autonomous vehicle is controlled by an algorithm, offering improved consistency and the potential to eliminate human error from driving: by far the most common cause of accidents. Data collected from different types of sensors, along with prior information such as maps, are used to build models of the surrounding traffic scene, encoding relevant aspects of the driving problem.These models allow the autonomous vehicle to plan how it will drive, optimizing comfort, safety and progress towards its destination. To do so we must first encode the context of the current driving situation: the road geometry, where different traffic participants are, including the autonomous vehicle, and what routes are available to them. To plan the autonomous vehicle's trajectory, we also require models of how other traffic participants are likely to move in the near future, and what risks are incurred for different potential trajectories of the autonomous vehicle. In this thesis we present an overview of different trajectory planning approaches and the models enabling them along with our contributions towards localization, intention recognition, predictive behavior models and risk inference methods that support trajectory planning. Our first contribution is a method that allows localization of anautonomous vehicle using automotive short range radars. Furthermore, we investigate behavior recognition and prediction using models at two different levels of abstraction. We have also explored the integration of two different trajectory planning algorithms and probabilistic environment models which allow us to optimize the expected cost of chosen trajectories.
Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells (2015)

The mevalonate pathway provides metabolites for post-translational modifications such as farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently occurring regulatory processes can induce an aberrant stimulation of DNA methyltransferase (DNMT1) as well as changes in histone deacetylases (HDACs) and microRNAs in many cancer cell lines. Inhibitors of the mevalonate pathway are increasingly recognized as anticancer drugs. Extensive evidence indicates an intense cross-talk between signaling pathways, which affect growth, differentiation, and apoptosis either directly or indirectly via epigenetic mechanisms. Herein, we show data obtained by novel transcriptomic and corresponding methylomic or proteomic analyses from cell lines treated with pharmacologic doses of respective inhibitors (i.e., simvastatin, ibandronate). Metabolic pathways and their epigenetic consequences appear to be affected by a changed concentration of NADPH. Moreover, since the mevalonate metabolism is part of a signaling network, including vitamin D metabolism or fatty acid synthesis, the epigenetic activity of associated pathways is also presented. This emphasizes the far-reaching epigenetic impact of metabolic therapies on cancer cells and provides some explanation for clinical observations, which indicate the anticancer activity of statins and bisphosphonates.
Novel therapeutics for bronchopulmonary dysplasia (2018)

BPD continues to be the most frequently occurring significant morbidity for extremely preterm infants, yet highly effective therapies remain elusive. Promising new treatments are on the horizon, but only continued efforts to complete well-designed clinical trials will determine the true impact of these emerging therapies.
Kinesin 18A expression: Clinical relevance to colorectal cancer progression (2011)

Kif18A, a member of the kinesin superfamily of molecular motor proteins, is a microtubule depolymerase and a key regulator of chromosome congregation. Kif18A's role in cancer progression has not been well defined. Our hypothesis is that Kif18A has a role in the progression of colorectal cancer (CRC). To investigate this expression of Kif18A, mRNA was assessed by quantitative real-time PCR in 113 operative specimens of primary CRC. Kif18A was overexpressed and significantly (p < 0.0001) higher in CRC than in normal colon tissue. Kif18A overexpression in CRC significantly correlated with clinicopathologic factors such as tumor stage (p < 0.0001), lymphatic invasion (p = 0.001), lymph node metastasis (p = 0.01), venous invasion (p = 0.002) and peritoneal dissemination (p = 0.02), suggesting that it has a key role in CRC progression. In multivariate analysis, high Kif18A expression had independent significance for poorer overall survival after resection of CRC (p = 0.037). To demonstrate Kif18A's role in CRC progression, we performed translational and in situ studies. Using in vitro studies on CRC cell lines, we evaluated Kif18A's role in proliferation, migration and invasion. CRC cells transfected with Kif18A cDNA demonstrated significant enhanced migration (p < 0.01) and invasion (p = 0.018) compared to mock-transfected cells. When Kif18A was targeted with specific small interfering RNA, CRC cells had significantly reduced proliferation (p < 0.01), migration (p < 0.01) and invasion (p < 0.05). The in vitro and translational studies demonstrated that Kif18A expression is related to events of metastasis and is a significant factor for CRC progression.
Glomerular ultrafiltration dynamics: euvolemic and plasma volume-expanded rats (1980)

With the use of micropuncture techniques, glomerular dynamics were characterized in euvolemic Munich-Wistar (Chapel Hil) rats. Single nephron glomerular filtration rate (SNGFR) and plasma flow (SNGPF) averaged 31 nl/min and 100 nl/min, respectively. Efferent effective ultrafiltration pressure (PUF) was greater than zero in each animal (7 mmHg, P less than 0.001), indicating filtration pressure disequilibrium. Mean PUF (PUF) was 15 mmHg and specific glomerular filtration coefficient (Kf) values averaged 0.033 nl/(s x mmHg). Similar experiments were performed on Munich-Wistar rats from B.M. Brenner's colony. Filtration pressure equilibrium was reached in rats with SNGPF < 112 nl/min; disequilibrium existed when SNGPF was > 168 nl/min. Overall, PUF (15 mmHg) was similar to that in Chapel Hill rats, SNGFR (49 nl/min) was greater, as was specific Kf (0.066 nl/(s.mmHg)). These observations document important Kf differences in the two colonies. In other experiments on Chapel Hill rats, plasma volume expansion produced increases in SNGPF and renal plasma flow (RPF). However, SNGFR (33 nl/min) and GFR (1.2 ml/(min x g kidney wt)) were unchanged, as were SNGFR/GFR and SNGPF/RPF ratios. SNGFR was relatively insensitive to increased plasma flow because of the relatively low Kf and filtration pressure disequilibrium during euvolemia. In additional experiments, GFR was also only weakly dependent on RPF in conscious rats.
Dear Computer, Teach Me Manners: Testing Virtual Employment Interview Training (2016)

Expanding research on employment interview training, this study introduces virtual employment interview (VI) training with focus on nonverbal behavior. In VI training, participants took part in a simulated interview with a virtual character. Simultaneously, the computer analyzed participants’ nonverbal behavior and provided real‐time feedback for it. The control group received parallel interview training. Following training, participants took part in mock interviews, where interviewers rated participants’ nonverbal behavior, and interview performance. Analyses revealed (a) that participants of VI training showed better interview performance, (b) that this effect was mediated by nonverbal behavior, and (c) that VI training has a positive influence on interview anxiety. These results have important practical implications for applicants, career counseling centers, and organizations.
Vaccination of Mice Using the West Nile Virus E-Protein in a DNA Prime-Protein Boost Strategy Stimulates Cell-Mediated Immunity and Protects Mice against a Lethal Challenge (2014)

West Nile virus (WNV) is a mosquito-borne flavivirus that is endemic in Africa, the Middle East, Europe and the United States. There is currently no antiviral treatment or human vaccine available to treat or prevent WNV infection. DNA plasmid-based vaccines represent a new approach for controlling infectious diseases. In rodents, DNA vaccines have been shown to induce B cell and cytotoxic T cell responses and protect against a wide range of infections. In this study, we formulated a plasmid DNA vector expressing the ectodomain of the E-protein of WNV into nanoparticles by using linear polyethyleneimine (lPEI) covalently bound to mannose and examined the potential of this vaccine to protect against lethal WNV infection in mice. Mice were immunized twice (prime -boost regime) with the WNV DNA vaccine formulated with lPEI-mannose using different administration routes (intramuscular, intradermal and topical). In parallel a heterologous boost with purified recombinant WNV envelope (E) protein was evaluated. While no significant E-protein specific humoral response was generated after DNA immunization, protein boosting of DNA-primed mice resulted in a marked increase in total neutralizing antibody titer. In addition, E-specific IL-4 T-cell immune responses were detected by ELISPOT after protein boost and CD8 + specific IFN-c expression was observed by flow cytometry. Challenge experiments using the heterologous immunization regime revealed protective immunity to homologous and virulent WNV infection.
An Algorithm of SNR Frequency-domain Estimation for SSB Signals (2009)

This paper presents a new SNR estimation algorithm in frequency-domain for SSB signals.The theoretic analysis is also given.As compared with other methods in time-domain,this method is proved very simple and robust.Monte Carlo simulation results show that the estimator bears high precision and the method is useful.Furthermore,a better estimation quality may be obtatined by using only smaller sampled data,and this method is especially suitable for short-term burst communication system.
A Survey of Parallel and Distributed Data Warehouses (2009)

Data Warehouses are a crucial technology for current competitive organizations in the globalized world. Size, speed and distributed operation are major challenges concerning those systems. Many data warehouses have huge sizes and the requirement that queries be processed quickly and efficiently, so parallel solutions are deployed to render the necessary efficiency. Distributed operation, on the other hand, concerns global commercial and scientific organizations that need to share their data in a coherent distributed data warehouse. In this article we review the major concepts, systems and research results behind parallel and distributed data warehouses.
Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E<sub>2</sub> and collagenase‐1 release from human corneal epithelial cells (1998)

1. We recently demonstrated the presence of phospholipase C-coupled bradykinin (BK) B2-receptors in human primary and SV40 virus-immortalized corneal epithelial (CEPI) cells. 2. The aims of the present studies were to demonstrate the specific binding of [3H]-BK to CEPI cell membranes and to study its pharmacological characteristics. In addition, we wished to study the functional coupling of the BK receptors to various physiological and pathological mechanisms in the CEPI cells, including phosphoinositide (PI) turnover, intracellular Ca2+-mobilization ([Ca2+]i), cell proliferation (via [3H]-thymidine incorporation), and the release of various cytokines, collagenase-1 (matrix metalloproteinase-1) and prostaglandin E2 (PGE2). 3. Specific [3H]-BK binding comprised 83 +/- 2% of the total binding, and was of high affinity (Kd = 1.66 +/- 0.52 nM, n = 5), saturable (Bmax = 640 +/- 154 fmol g(-1) wet weight) and reversible. Competition studies yielded the following affinity values for BK and a number of BK-related peptides: Hoe-140 (D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]BK; icatibant): Ki = 0.17 +/- 0.07 nM; BK: Ki = 1.0 +/- 0.11 nM; [Tyr8]-BK: Ki = 12.9 +/- 2.3 nM; [des-Arg9]-BK: Ki > 9,200 nM (all n = 3-5)). 4. BK potently stimulated PI turnover (EC50 = 2.3 +/- 0.3 nM; n = 7) and [Ca2+]i mobilization (EC50 = 8-20 nM) in CEPI cells and both responses were inhibited in a concentration-dependent manner by 100 nM-10 microM Hoe-140, a selective B2-receptor antagonist, and also inhibited by the selective phospholipase C (PLC) inhibitor, U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1 H-pyrrole-2,5-dione) (IC50 = 3.0 +/- 1.6 microM). BK-induced [Ca2+]i mobilization was reduced by about 30% in the presence of 4 mM EGTA, but was not significantly affected by 100 nM nifedipine. 5. BK (0.1 nM-10 microM) significantly (P<0.05-0.001) stimulated [3H]-thymidine incorporation into CEPI cellular DNA. However, while interleukin-1alpha (IL-1alpha; 10 ng ml(-1)) potently stimulated the release of IL-6, IL-8 and granulocyte macrophage colony-stimulating factor from CEPI cells, BK (0.1 nM-10 microM) was without effect. 6. Whilst phorbol-12-myristate-13-acetate (PMA; 3 microg ml(-1)) and 10% foetal bovine serum (positive control agents) significantly stimulated the release of both MMP-1 and PGE2 from CEPI cells, BK (0.1 nM-10 microM) was without any significant effect under these conditions. 7. In conclusion, these data indicate that the CEPI cells express high-affinity [3H]-BK binding sites representing B2-subtype BK receptors coupled to PI turnover and [Ca2+]i mobilization which appear to stimulate [3H]-thymidine incorporation into cellular DNA. In contrast, BK failed to elicit the release of PGE2, various cytokines and MMP-1 from CEPI cells. These results suggest that BK may have a potential role in corneal epithelium wound healing by stimulating cell proliferation.
Proportional reactive power sharing algorithm in Islanded AC microgrid (2015)

A microgrid (MG) is a local energy system consisting a number of energy sources (e.g. wind turbine or solar panels), energy storage units and loads that operate connected to the main electrical grid or autonomously. MGs require complex management and advanced control. One of the most important parts in microgrid structure are power electronic converters (PEC). They provide correct energy conversion from every Renewable Energy Sources (RES) and common control structure for whole system. In islanded microgrid a Classical Droop Control is usually implemented, which allows for the correct operation of parallel voltage source converters (VSC). However, additional complex power management algorithm is required, which balances system and improves reliability. The novel reactive power sharing algorithm is described in this paper, which takes into account the converter parameters as apparent power limit and maximum active power. The developed solution is verified in experimental research and compared with other known reactive power control methods.
A Study on the Search of Optimal Aquaculture farm condition based on Machine Learning (2017)

세계 수산시장은 초과 수요적 현상으로 이러한 경향은 지속적으로 가속화 될 것으로 전망하고 있다. 수산물 수요가 증가되는 양식업은 어업과 비교해 볼 때 비교적 적은 자원의 투입으로도 생산량의 조절 및 표준화 등이 가능하여 높은 성과를 얻을 수 있는 산업이다. 그러나 전통적인 양식은 자연재해, 생태계 오염 등 저생산성의 문제점을 안고 있어 최적의 양식장소로 이동할 수 있는 새로운 양식시스템의 개발이 필요하다. 최적의 장소를 찾기 위해서는 온도, 산소 용존량 등 필요한 데이터를 실시간으로 수집하고 분석해야 한다. 데이터 분석은 머신러닝 기반의 K-means 클러스터링 기법을 적용하여 반복된 자기학습으로 언제, 어디로 양식장을 이동할지 스스로 판단할 수 있도록 하였다. 제시한 연구결과가 어류 양식업 종사자에게 적용된다면 최적의 양식장소를 스스로 찾아감으로써 자연재해, 생태계 오염 등 저생산성의 문제점을 해결 할 수 있을 것이다. The demand for aquatic products in the domestic and overseas is increased, so that the aquaculture industry can achieve high performance by controlling and standardizing the production even with a relatively small amount of resources compared with existing fisheries. However, traditional method has problems of low productivity such as natural disasters and ecosystem pollution, and it is necessary to develop a new culture system that can move to the optimal culture site. In order to find the optimal location, you need to collect and analyze the necessary data such as temperature and DO in real time. Data analysis was performed by using K-means clustering method based on machine learning, so that it was possible to decision when and where to move the farm by repeated unsupervised learning. The proposed research could solve the problems of low productivity such as natural disasters and ecosystem pollution if applied to regressive fish farmers.
Model for mediastinal lymph node metastasis produced by orthotopic intrapulmonary implantation of lung cancer cells in mice. (1999)

This study is designed to establish a pulmonary tumor model to investigate the biology and therapy of lung cancer in mice. Current methods for forming a solitary intrapulmonary nodule and subsequent metastasis to mediastinal lymph nodes are not well defined. Lewis lung carcinoma cell (LLC) suspensions were orthotopically introduced into the lung parenchyma of C57/BL6 mice via a limited skin incision without thoracotomy followed by direct puncture through the intercostal space. The implantation process was performed within approximately 50 sec per mouse, and the operative mortality was less than 5%. Single pulmonary nodules developed at the implanted site in 93% of animals and subsequent mediastinal lymph nodes metastasis were observed in all mice that were succeeded to form a lung nodule after intrapulmonary implantation. The size of tumor nodule and the weight of mediastinal lymph node increased in a time-dependent manner. The mean survival time of mice implanted successfully with LLC cells was 21 +/- 2 days (range; 19-24 days). Histopathological analysis revealed that no metastatic tumor was detectable in the mediastinal lymph nodes on day 11, but metastatic foci at mediastinal lymph nodes were clearly observed on days 17 and 21 after implantation. Other metastases in distant organs or lymph nodes were not observed at 21 days after the implantation. Comparative studies with intrapleural and intravenous injections of LLC cells suggest that the mediastinal lymph node metastasis by intrapulmonary implantation is due to the release of tumor cells from the primary nodule, and not due to extrapulmonary leakage of cells. An intravenous administration of CDDP on day 1 after tumor implantation tended to suppress the primary tumor nodule and significantly inhibited the lymph node metastasis. Thus, a solitary pulmonary tumor nodule model with lymph node metastasis approximates clinical lung cancer, and may provide a useful basis for lung cancer research.
Tool of the 90's To Optimize Gas-Lift Efficiency in the Gonelle Field, Gabon (1991)

ABSTRACT This paper presents a new method, successfully implemented in March 1990, of operating Gonelle field wells in Gabon. Permanent actions of a programmable logic controller in respect to an expert logic ensure continuous production of the wells with a minimum gas injection rate. A sharp production increase has been possible despite a simultaneous decrease in gas consumption.
Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides (2013)

Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies revealed that most of the resistance-associated genes functioning in diverse mechanisms are expressed in the epidermal layer of the integument, which could prevent or slow down the toxin from reaching the target sites on nerve cells, where an additional layer of resistance (kdr) is possible. This strategy evolved in bed bugs is based on their unique morphological, physiological and behavioral characteristics and has not been reported in any other insect species. RNA interference-aided knockdown of resistance associated genes showed the relative contribution of each mechanism towards overall resistance development. Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods.