gebhart/patrepeval huggingface dataset:
A New Regularized Solution to Ill-Posed Problem in Coordinate Transformation (2012)

Coordinates transformation is generally required in GPS applications. If the transformation parameters are solved with the known coordinates in a small area using the Bursa model, the precision of transformed coordinates is generally very poor. Since the translation parameters and rotation parameters are highly correlated in this case, a very large condition number of the coefficient matrix A exists in the linear system of equations. Regularization is required to reduce the effects caused by the intrinsic ill-conditioning of the problem and noises in the data, and to stabilize the solution. Based on advanced regularized methods, we propose a new regularized solution to the ill-posed coordinate transformation problem. Simulation numerical experiments of coordinate transformation are given to shed light on the relationship among different regularization approaches. The results indicate that the proposed new method can obtain a more reasonable resolution with higher precision and/or robustness.
Cultivation of Chlamydia trachomatis in cycloheximide-treated mccoy cells (1977)

An isolation technique for Chlamydia trachomatis using McCoy cells is described. In contrast to earlier techniques employing such cells, no pretreatment of the cells was used. The glutarimide antibiotic cycloheximide was added to the culture medium used for incubating the cells after infection. Cycloheximide was used at concentrations that depressed, but did not completely inhibit, the metabolism of the eucaryotic host cells. In studies on different immunotypes of C. trachomatis cultured in the yolk sac of embryonated hen eggs, the cycloheximide technique was compared with a method using pretreatment of cells with 5-iodo-2-deoxyuridine. The cycloheximide method gave greater numbers of inclusion-forming units per cover slip for all the immunotypes of trachoma-inclusion conjunctivitis agents tested, i.e., A through I. In a study of 194 cervical and urethral specimens from women, cycloheximide treatment of McCoy cells was found to be more efficient than 5-iodo-2-deoxyuridine treatment for the isolation of C. trachomatis.
Evaluation of activity-based costing versus resource-based relative value costing. (2004)

Activity-based costing (ABC) and relative value units costing (RVU) are two approaches that a practice manager can use to determine the cost of physician services. Each costing approach has features that provide distinction as well as differentiation in the cost estimates that are estimated. This paper will provide cost estimates under each approach along with cost estimates under a hybrid approach that merges features from each costing approach known as the ABC-RVU costing technique. A comparison of the results will be provided.
Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas (2011)

The p53 pathway is critical for tumor suppression, as the majority of human cancer has a faulty p53. Here, we identified RNPC1, a p53 target and a RNA-binding protein, as a critical regulator of p53 translation. We showed that ectopic expression of RNPC1 inhibited, whereas knockdown of RNPC1 increased, p53 translation under normal and stress conditions. We also showed that RNPC1 prevented cap-binding protein eIF4E from binding p53 mRNA via its C-terminal domain for physical interaction with eIF4E, and its N-terminal domain for binding p53 mRNA. Consistent with this, we found that RNPC1 directly binds to p53 5' and 3'untranslated regions (UTRs). Importantly, we showed that RNPC1 inhibits ectopic expression of p53 in a dose-dependent manner via p53 5' or 3' UTR. Moreover, we showed that loss of RNPC1 in mouse embryonic fibroblasts increased the level of p53 protein, leading to enhanced premature senescence in a p53-dependent manner. Finally, to explore the clinical relevance of our finding, we showed that RNPC1 was frequently overexpressed in dog lymphomas, most of which were accompanied by decreased expression of wild-type p53. Together, we identified a novel p53-RNPC1 autoregulatory loop, and our findings suggest that RNPC1 plays a role in tumorigenesis by repressing p53 translation.
Microencapsulation of Metal-based Phase Change Material for High-temperature Thermal Energy Storage (2015)

Latent heat storage using alloys as phase change materials (PCMs) is an attractive option for high-temperature thermal energy storage. Encapsulation of these PCMs is essential for their successful use. However, so far, technology for producing microencapsulated PCMs (MEPCMs) that can be used above 500°C has not been established. Therefore, in this study, we developed Al-Si alloy microsphere MEPCMs covered by α-Al2O3 shells. The MEPCM was prepared in two steps: (1) the formation of an AlOOH shell on the PCM particles using a boehmite treatment, and (2) heat-oxidation treatment in an O2 atmosphere to form a stable α-Al2O3 shell. The MEPCM presented a melting point of 573°C and latent heat of 247 J g(-1). The cycling performance showed good durability. These results indicated the possibility of using MEPCM at high temperatures. The MEPCM developed in this study has great promise in future energy and chemical processes, such as exergy recuperation and process intensification.
Heat shock affects 5′ splice site selection, cleavage and ligation of CAD pre-mRNA in hamster cells, but not its packaging in InRNP particles (1994)

The effect of heat shock on the packaging and splicing of nuclear CAD pre-mRNA, a transcript expressed constitutively from a non heat-inducible promoter, was studied in vivo in Syrian hamster cells. While mild heat shock did not affect significantly the packaging of CAD RNA in 200S InRNP particles, it caused perturbation to splicing. First, the heat shock inhibited splicing of CAD pre-mRNA. Second, it affected 5' splice site selection by activating cleavage at a cryptic 5' splice site; yet ligation of the cryptic exon to the downstream proximal exon was not observed. Base complementarities of the cryptic site with U1, U5, or U6 snRNAs are comparable, or even better, than those with the neighboring normal site. Hence, the exclusion of the cryptic site under normal growth conditions cannot be attributed to weaker base pairing with these snRNAs. On the other hand, these results imply the involvement of a heat labile factor in the selection of the 5' cleavage site. The exclusion of the cryptic site at 37 degrees C and the aborted splicing at this site after heat shock may also be explained by a proposed nuclear checking mechanism that detects in-frame stop codons upstream of the 5' splice site, and aborts splicing at such sites to prevent the production of a defective message.
Nanoparticle formulations in pulmonary drug delivery (2008)

The advent of nanotechnology has reignited interest in the lungs as a major route of drug delivery for both systemic and local treatments. The large surface area of the lungs and the minimal barriers impeding access to the lung periphery make this organ a suitable portal for a variety of therapeutic interventions. Nanoparticles provide new formulation options for both dispersed liquid droplet dosage forms such as metered dose inhalers and nebulizers, and dry powder formulations. Nanoparticle formulations have many advantages over traditional dosage forms, such as enhanced dissolution properties and the potential for intracellular drug delivery. Specifically, pure drug nanoparticles, polymeric nanoparticles, polyelectrolyte complexes, and drug-loaded liposomes offer some encouraging results for delivering drugs to and through the lungs. Methods are also being investigated to produce nanoparticles with properties suitable for improving access to the peripheral lung. Traditional techniques such as spray drying and grinding, and more recent advances in supercritical fluid extraction, precipitation, and solvent extraction have been employed to produce nanoparticle formulations for pulmonary delivery. Here, the benefits of nanoparticle formulations and current progress are compared in light of the practical encumbrances of producing formulations, and possible toxicological effects of these materials.
Synthesis, characterization, and thermally activated curing of oligosiloxanes containing benzoxazine moieties in the main chain (2008)

Abstract Oligosiloxanes containing thermally curable benzoxazine units in the main chain have been synthesized. For this purpose, first the diallyl functional monomer is synthesized through the Mannich and ring closing reaction of 4,4′‐isopropylidenediphenol (bisphenol A), formaldehyde and allylamine. Hydrosilylation reaction of the resulting diallylic monomer (B‐ala) with 1,1,3,3‐tetramethyldisiloxane (TMDS) in the presence of Pt catalyst yields the corresponding poly(B‐ala‐tetramethyl disiloxane)s (PBTMDS) with the molecular weights in the range of 1800–4100 Da. The structures of the precursor diallyl monomer and the resulting polymers are confirmed by FT‐IR and 1 H NMR analysis. Curing behavior of both the monomer and polymers has also been studied by Differential Scanning Calorimetry (DSC). Flexible free standing transparent films of the oligosiloxanes are obtained by solvent casting from dichloromethane solution on Teflon plates. The films preserve shape and, to some extent, toughness after thermal curing between 100 and 180 °C. Thermal properties of the cured polymers are also investigated by thermogravimetric analysis (TGA). © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 804–811, 2009
Efficient Image Evidence Analysis of CNN Classification Results (2018)

Convolutional neural networks (CNNs) define the current state-of-the-art for image recognition. With their emerging popularity, especially for critical applications like medical image analysis or self-driving cars, confirmability is becoming an issue. The black-box nature of trained predictors make it difficult to trace failure cases or to understand the internal reasoning processes leading to results. In this paper we introduce a novel efficient method to visualise evidence that lead to decisions in CNNs. In contrast to network fixation or saliency map methods, our method is able to illustrate the evidence for or against a classifier's decision in input pixel space approximately 10 times faster than previous methods. We also show that our approach is less prone to noise and can focus on the most relevant input regions, thus making it more accurate and interpretable. Moreover, by making simplifications we link our method with other visualisation methods, providing a general explanation for gradient-based visualisation techniques. We believe that our work makes network introspection more feasible for debugging and understanding deep convolutional networks. This will increase trust between humans and deep learning models.
Les faits de santé aux cours et décours des sécheresses (1991)

Il est difficile d’evaluer objectivement l’impact de la secheresse sur l’etat de sante des populations affectees, tant la charge emotionnelle associee au spectre du desastre est fortement ancree dans les esprits. En fait, les consequences les plus graves sont dues a des facteurs associes tels que mouvements de population, insurrections et guerres civiles, rupture des cadres de la vie sociale, problemes de refugies, etc. Certaines maladies infectieuses, comme la meningite, le cholera, les diarrhees, paraissent susceptibles de s’aggraver au cours d’une periode de secheresse, tandis que d’autres, comme le paludisme ou la maladie du sommeil, regresseraient ; certains episodes de malnutrition qualitative ont ete observes, mais c’est la malnutrition quantitative et son resultat - la famine - que l’on met en cause dans la mortalite massive des secheresses. Pourtant, tandis qu’une mortalite tres elevee frappe la population de zones durement touchees, d’autres populations qui ne sont pas moins touchees ont su developper des mecanismes de compensation. Certaines communautes, malgre l’absence d’assistance exterieure, ne se trouvent pas confrontees a des situations insoutenables. Les aides exterieures ont tres souvent un effet de destabilisation des services de sante, sensible au-dela de la zone touchee et encore bien apres la fin de la secheresse proprement dite. La secheresse est un facteur d’environnement qui peut aggraver serieusement les conditions de vie des societes humaines. Celles-ci ont en general developpe des mecanismes d’ajustement a une penurie passagere. Un desastre se produit lorsque la rigidite du systeme socio-economique ne permet pas les ajustements necessaires ou lorsque les desordres socio-politiques ne permettent aucun ajustement.
Power recovery from data line in avionic applications (2012)

In this paper, we propose a novel power recovery approach to reduce the mass of the cables installed in aircrafts. The power recovery unit harvests energy from data field bus which is recently presented to modify classical Avionics Full Duplex Ethernet (AFDX) networks, to power up the Smart Sensor Interface (SSI) module entirely. A top-down modeling approach in Verilog-A is used to build complex modules in the Power Conversion Chain (PCC) which makes power transfer and distribution possible. The effects of frequency and the size of capacitor reservoir on settling time and output voltage ripple are studied. Simulation results in system level prove that the proposed power recovery scheme could procure and deliver significant amount of power to SSI which makes the structure self-powered and therefore additional power lines are saved.
A Statistical Damage Mechanics Model for Subsurface Initiated Spalling in Rolling Contacts (2008)

Fatigue lives of rolling element bearings exhibit a wide scatter due to the statistical nature of the rolling contact fatigue failure process. Empirical life models that account for this dispersion do not provide insights into the physical mechanisms that lead to this scatter. One of the primary reasons for dispersion in lives is the stochastic nature of the bearing material. Here, a damage mechanics based fatigue model is introduced in conjunction with the idea of discrete material representation that takes the effect of material microstructure explicitly into account. Two sources of material randomness are considered: (1) the topological randomness due to geometric variability in the material microstructure and (2) the material property randomness due to nonuniform distribution of properties throughout the material. The effect of these variations on the subsurface stress fields in rolling element line contacts is studied. The damage model, which incorporates cyclic damage accumulation and progressive degradation of material properties with rolling contact cycling, is used to study the mechanisms of subsurface initiated spalling in bearing contacts. Crack initiation as well as propagation stages are modeled using damaged material zones in a unified framework. The spalling phenomenon is found to occur through microcrack initiation below the surface where multiple microcracks coalesce and subsequent cracks propagate to the surface. The computed crack trajectories and spall profiles are found to be consistent with experimental observations. The microcrack initiation phase is found to be only a small fraction of the total spalling life and the scatter in total life is primarily governed by the scatter in the propagation phase of the cracks through the microstructure. Spalling lives are found to follow a three-parameter Weibull distribution more closely compared to the conventionally used two-parameter Weibull distribution. The Weibull slopes obtained are within experimentally observed values for bearing steels. Spalling lives are found to follow an inverse power law relationship with respect to the contact pressure with a stress-life exponent of 9.35.
Clinical presentation of adults with pulmonary tuberculosis with and without HIV infection in Nigeria (2007)

Our aim was to describe the frequency of HIV infection among patients with tuberculosis and compare their characteristics with patients with TB but not infected with HIV. Patients with cough >3 weeks duration attending 8 hospitals in Abuja, Nigeria were screened with smear microscopy and culture and tested for HIV. Chest X-rays were graded by 2 readers. 731 (62%) of 1186 patients had positive cultures and 353 (48%) of these 731 patients were smear positive. 1002 (85%) patients were tested for HIV and 546 (55%) were positive. 53% (329/625) of the culture positive patients and 58% (217/377) of the culture negative patients were HIV positive. Anorexia, weight loss, low BMI (<18.5), haemoglobin (<11 gm/dl) and albumin and high ESR and liver enzymes were more frequently observed among patients with TB coinfected with HIV than in patients without HIV. Coinfected patients had less cavitations and lung involvement on X-rays than patients without HIV. In conclusion, the prevalence of HIV is very high among patients with TB in Abuja, Nigeria. The presence of HIV decreases the sensitivity of smear microscopy and complicates the diagnosis of TB. Selected clinical and laboratory parameters could be used to identify individuals with TB who are likely to be coinfected with HIV.
Direct Torque Control of Permanent-Magnet Synchronous Machine Drives With a Simple Duty Ratio Regulator (2014)

The conventional switching-table-based direct-torque-controlled (DTC) ac machine drive is usually afflicted by large torque ripple, as well as steady-state error of torque. The existing methods, which optimize the duty ratio of the active vector, are usually complicated and parameter dependent. Based on the analysis of instantaneous variation rates of stator flux and torque of each converter output voltage vector, a simple and effective method considering the effect of machine angular velocity is proposed to obtain the duty ratio. The experimental results carried on a dSPACE platform with a laboratory prototype of the permanent-magnet machine verify that the proposed duty-based DTC method can achieve excellent transient response, less torque ripple, and less steady-state error, without resorting to the complicated control method over a wide range of operating regions.
Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years (2005)

Current research into dietary factors contributing to the development of allergic diseases is directed towards new active approaches instead of passive elimination diets. The present study aimed to investigate the explanatory role of the diet in a probiotic intervention study on the appearance of atopic eczema (AE) in childhood and the safety of perinatal supplementation with probiotics (Lactobacillus rhamnosus strain GG; ATCC 53 103). A prospective follow-up study from birth to 48 months of children (n 159) with a family history of allergic disease was carried out. Outcome measures included growth, dietary intake assessed with 4 d food diaries and their association with AE by logistic regression models. Increased intakes of retinol, Ca and Zn, with perinatal administration of probiotics, reduced the risk of AE, whilst an increase in intake of ascorbic acid increased the likelihood of AE. Perinatal administration of probiotics was safe, as it did not influence the height (mean difference 0.04 (95 % CI -0.33, 0.40) sd scores, P=0.852) or the weight-for-height (mean difference -3.35 (95 % CI -7.07, 0.37)%, P=0.077) of the children at 48 months with and without perinatal administration of probiotics. Up to 48 months, AE did not affect height (mean difference -0.05 (95 % CI -0.42, 0.33) sd scores, P=0.815), but mean weight-for-height in children with AE was -5.1 % (95 % CI -8.9, -1.2 %) lower compared with children without (P=0.010). The joint effects of nutrients and probiotics need to be considered in active prevention and management schemes for allergic diseases.
Statistical Analysis of Multicast versus Instant Channel Changing Unicast IPTV Provisioning (2008)

Bandwidth is a key constraint for video distribution and hence, there is a strong incentive for analysis and modelling of IPTV service. In this paper we provide statistical analysis of IPTV traces measured from real-life IPTV pre-operational network. The main target was to determine the trade off between the multicast distribution of IPTV and ICC (Instant Channel Changing) unicast distribution of this service to the end users. The results showed that multicast and unicast IPTV traffic have different self-similarity degrees, where the multicast is shown to be less self-similar, while ICC unicast traffic showed middle level burstiness. The obtained results provide important information for service and network providers in the area of network design for IPTV provisioning.
Fine pattern etching of molybdenum by using atmospheric line shaped micro plasma source (2003)

Various atmospheric micro plasma sources for maskless etching have been proposed. This report briefly summarizes the concept of our line shaped micro plasma source and presents fine pattern etching experiment of molybdenum thin film.
ChemInform Abstract: CATALYST FOR FLUORINATION OF ORGANIC CHLOROCOMPOUNDS (1982)

Abstract Für die Gasphasenfluorierung von chlorierten Methanen und Ethanen sowie Hexachloraceton mit Fluorwasserstoff bei 255 ‐ 400°C ist aus Kaliumchromalaun erhaltenes Chromoxid geeigneter als aus Chrom(III)‐chlorid und ‐nitrat hergestelltes.
Alpha-2 adrenergic agonism stimulates islet glucagon release from perfused rat pancreas: possible involvement of alpha-2A adrenergic receptor subtype (1992)

Although insulin release is known to be inhibited by alpha-2 adrenergic agonism, the effect of alpha adrenergic agonism on islet glucagon release remains controversial. Alpha-2 adrenoceptors are subdivided into alpha-2A and alpha-2B subtypes using receptor binding methods or cloning methodology. This study was designed to confirm the involvement of the alpha-2 adrenoceptor and its subtypes in glucagon release from the isolated, perfused rat pancreas. Both the alpha-2A preferential agonist oxymetazoline and the non-subtype-selective alpha-2 agonist clonidine induced concentration-dependent stimulation of glucagon release, starting at 10(-8) and 10(-7) mol/l, respectively (p < 0.01). In contrast, neither of the two alpha-1 selective agonists, methoxamine and phenylephrine, at concentrations up to 10(-6) mol/l affected glucagon release. Furthermore, the non-subtype-selective alpha-2 antagonist rauwolscine at concentrations of 10(-6) and 10(-5) mol/l and the alpha-1 and alpha-2A selective antagonist WB-4101 at 10(-5) mol/l showed significant antagonism of 10(-7) mol/l clonidine-induced glucagon release versus corresponding controls. Neither the alpha-1 and alpha-2B selective antagonist prazosin nor the alpha-2B preferential antagonist chlorpromazine, at concentrations up to 10(-5) mol/l, antagonized the effects of clonidine. None of the eight drugs, at the concentrations tested, affected insulin release with 5.5 mmol/l glucose. These results suggest that in rats islet glucagon release induced by alpha adrenoceptor agonism is mediated through alpha-2 adrenoceptors, possibly the alpha-2A subtype.
Pattern Mining in Frequent Dynamic Subgraphs (2006)

Graph-structured data is becoming increasingly abundant in many application domains. Graph mining aims at finding interesting patterns within this data that represent novel knowledge. While current data mining deals with static graphs that do not change over time, coming years will see the advent of an increasing number of time series of graphs. In this article, we investigate how pattern mining on static graphs can be extended to time series of graphs. In particular, we are considering dynamic graphs with edge insertions and edge deletions over time. We define frequency in this setting and provide algorithmic solutions for finding frequent dynamic subgraph patterns. Existing subgraph mining algorithms can be easily integrated into our framework to make them handle dynamic graphs. Experimental results on real-world data confirm the practical feasibility of our approach.