gebhart/patrepeval huggingface dataset:
Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/ <i>KMT2A</i> (2020)

Balanced rearrangements involving the <i>KMT2A</i> gene, located at 11q23, are among the most frequent chromosome aberrations in acute myeloid leukemia (AML). Because of numerous fusion partners, the mutational landscape and prognostic impact of specific 11q23/<i>KMT2A</i> rearrangements are not fully understood. We analyzed clinical features of 172 adults with AML and recurrent 11q23/<i>KMT2A</i> rearrangements, 141 of whom had outcome data available. We compared outcomes of these patients with outcomes of 1,097 patients without an 11q23/<i>KMT2A</i> rearrangement categorized according to the 2017 European LeukemiaNet (ELN) classification. Using targeted next-generation sequencing, we investigated the mutational status of 81 leukemia/cancer-associated genes in 96 patients with 11q23/<i>KMT2A</i> rearrangements with material for molecular studies available. Patients with 11q23/<i>KMT2A</i> rearrangements had a low number of additional gene mutations (median, 1; range 0 to 6), which involved the RAS pathway (<i>KRAS</i>, <i>NRAS</i>, and <i>PTPN11</i>) in 32% of patients. <i>KRAS</i> mutations occurred more often in patients with t(6;11)(q27;q23)/<i>KMT2A</i>-<i>AFDN</i> compared with patients with the other 11q23/<i>KMT2A</i> subsets. Specific gene mutations were too infrequent in patients with specific 11q23/<i>KMT2A</i> rearrangements to assess their associations with outcomes. We demonstrate that younger (age <60 y) patients with t(9;11)(p22;q23)/<i>KMT2A</i>-<i>MLLT3</i> had better outcomes than patients with other 11q23/<i>KMT2A</i> rearrangements and those without 11q23/<i>KMT2A</i> rearrangements classified in the 2017 ELN intermediate-risk group. Conversely, outcomes of older patients (age ≥60 y) with t(9;11)(p22;q23) were poor and comparable to those of the ELN adverse-risk group patients. Our study shows that patients with an 11q23/<i>KMT2A</i> rearrangement have distinct mutational patterns and outcomes depending on the fusion partner.
Laser separation of flat glass in electronic-, optic-, display-, and bio-industry (Invited Paper) (2005)

Up until now, conventional cutting methods by using metal or diamond wheels have been widely in use in numerous glass industries. Along with the market trend towards clean and more sophisticated process, constraints by the traditional methods have been unavoidable. Hence, laser separation is seen as an alternative and breakthrough solution to many and in this paper, an overview on laser separation as a whole is provided in terms of its process theories and its system as process equipment. Also glass application varieties as well as market requirements are discussed.
ChemInform Abstract: Amino Acids of the Adamantane Series. Part l. Synthesis and Antiviral Activity of Adamantane a‐Aminoacids and Their Derivatives. (1986)

Abstract Ausgehend von den Adamantyl‐a‐amino‐carbonsäuren (I), erhältlich aus den entsprechenden α‐Halogen‐carbonsäuren nach bekannten Methoden, werden die Derivate (II)‐(V) hergestellt und auf ihre virozide Wirkung geprüft.
Need data for driver behaviour analysis? Presenting the public UAH-DriveSet (2016)

Driving analysis is a recent topic of interest due to the growing safety concerns in vehicles. However, the lack of publicly available driving data currently limits the progress on this field. Machine learning techniques could highly enhance research, but they rely on large amounts of data which are difficult and very costly to obtain through Naturalistic Driving Studies (NDSs), resulting in limited accessibility to the general research community. Additionally, the proliferation of smartphones has provided a cheap and easy-to-deploy platform for driver behavior sensing, but existing applications do not provide open access to their data. For these reasons, this paper presents the UAH-DriveSet, a public dataset that allows deep driving analysis by providing a large amount of data captured by our driving monitoring app DriveSafe. The application is run by 6 different drivers and vehicles, performing 3 different behaviors (normal, drowsy and aggressive) on two types of roads (motorway and secondary road), resulting in more than 500 minutes of naturalistic driving with its associated raw data and processed semantic information, together with the video recordings of the trips. This work also introduces a tool that helps to plot the data and display the trip videos simultaneously, in order to ease data analytics. The UAH-DriveSet is available at: http:// www.robesafe.com/personal/eduardo.romera/uah-driveset.
[Formulation of photocurable bonding liner and adhesion to dentin. Effect of photoinitiator, monomer and photoirradiation]. (1989)

An investigation was undertaken to evaluate the effect of both photoinitiators (camphor-quinone-amine systems) and the adhesion promoting monomer (4-MET) on photopolymerization of bonding liners and their adhesion to dentin. Photopolymerization of bonding liners was measured with differential scanning calorimetry (DSC). The bonding liner containing 2-(dimethylamino)ethyl methacrylate (DMAEMA) as a reducing agent decreased the rate of polymerization in the presence of 4-MET. On the other hand, the bonding liners containing N-phenylglycine (NPG) and N,N-dimethylaniline derivatives as a reducing agent showed good polymerization in the presence of 4-MET. The results of the tensile bond test suggested that bonding liners containing NPG and 4-(dimethylamino)benzoic acid (DMABA), one of the N,N-dimethylaniline derivatives, with or without 4-MET bonded well to dentin treated with EDTA 3-2. NPG and DMABA are recommended not only as reducing agents but also as aids in the diffusion of monomers into the dentin substrate. The relationship between the strength of the bond to dentin and photoirradiation of the bonding liner and composite resin was studied. Elongation of photoirradiation of both the bonding liner and composite resin was effective in impacting the strength of the bond to dentin. Furthermore, sufficient photoirradiation of the bonding liner prior to any filling of composite resin was especially important to obtain high bond strengths. SEM and TEM observations supported good adhesion being achieved by hybrid formations between photocurable bonding liners and dentin.
Inhibitory effects of neurocan and phosphacan on neurite outgrowth from retinal ganglion cells in culture. (2001)

Neurocan and phosphacan, which are highly expressed in postnatal rat retina, inhibit neurite outgrowth from postnatal rat RGCs, indicating that these proteoglycans may be inhibitory factors against neurite outgrowth from RGCs during retinal development.
A Variable-Gain Low-Noise Transimpedance Amplifier for Miniature Ultrasound Probes (2020)

This article presents a low-noise transimpedance amplifier (TIA) designed for miniature ultrasound probes. It provides continuously variable gain to compensate for the time-dependent attenuation of the received echo signal. This time-gain compensation (TGC) compresses the echo-signal dynamic range (DR) while avoiding imaging artifacts associated with discrete gain steps. Embedding the TGC function in the TIA reduces the output DR, saving power compared to prior solutions that apply TGC after the low-noise amplifier. The TIA employs a capacitive ladder feedback network and a current-steering circuit to obtain a linear-in-dB gain range of 37 dB. A variable-gain loop amplifier based on current-reuse stages maintains constant bandwidth in a power-efficient manner. The TIA has been integrated in a 64-channel ultrasound transceiver application-specific integrated circuit (ASIC) in a 180-nm BCDMOS process and occupies a die area of 0.12 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . It achieves a gain error below ±1 dB and a 1.7 pA/√Hz noise floor and consumes 5.2 mW from a ±0.9 V supply. B-mode images of a tissue-mimicking phantom are presented that show the benefits of the TGC scheme.
The mechanism of the initiation reaction of the cationic polymerization of tetrahydrofuran by stable cationic salts (1971)

Abstract The mechanism of the initiation reaction for the polymerization of cyclic ethers and lactones by triethyloxonium‐, acetyl‐ and dioxolenium‐salts was studied. Triethyloxonium salts initiate the polymerization of cyclic ethers simply by the alkyl exchange reaction. Cyclic esters react with triethyloxonium salts at both ether and carbonyl oxygens but the polymerization proceeds by the acyl‐oxygen fission. The k p value of the polymerization of THF by triethyloxonium salts is almost constant independent of gegenanion. Acetyl cation initiates the polymerization of THF partly by bonding mechanism, but dioxolenium salt initiates completely by bonding.
A Poly(Ethylene Glycol) Water-soluble Conjugate of Porin: Refolding to the Native State (1995)

Porin, from Rhodabacter capsulatus, was chemically modified with methoxypoly(ethylene glycol) (m-PEG; molecular mass = 5000 Da) succinimidyl carbonate to yield methoxypoly(ethylene glycol)-porin (m-PEG-SC-Porin), as previously reported for bacteriorhodopsin [Sirokman, G., & Fasman, G. D. (1993) Protein Sci. 3, 1101-1170]. The m-poly(ethylene glycol)-porin (m-PEG-SC-Porin 50) conjugate, containing one poly(ethylene glycol) chain, was water soluble. The secondary structure of the conjugate in water was mainly random coil. Circular dichroism spectroscopy showed it was predominantly in the beta-pleated sheet structure in 0.6% octyltetraoxyethylene and 0.3 M LiCl, as was porin. A proteoliposome, containing the isolated porin conjugate, was prepared to measure permeability of the sugar stachyose. The m-PEG-SC-Porin 50 proteoliposome of porin maintained the permeability for the sugar, as did the proteoliposome of porin. The swelling rate of the conjugate versus the sugar was lower than it was for porin. This indicated that a pore in the conjugate exists but perhaps with a slightly different pore size. The refolding of the conjugate was studied by stepwise addition of trifluoroethanol (TFE) to lower the dielectric constant, simulating the insertion of porin into the membrane. An alpha-helical structure that did not exist in the native porin was formed with the m-PEG-SC-Porin 50, upon the addition of TFE, and the helicity increased with increasing concentrations of TFE. The m-PEG-SC-Porin 50 could be stepwise refolded to the native conformation, predominantly in the beta-sheet conformation, by the addition of hexafluoro-2-propanol in the 5-10% concentration range.(ABSTRACT TRUNCATED AT 250 WORDS)
Highly Conductive Room Temperature Molten Salts Based on Small Trimethylalkylammonium Cations and Bis(trifluoromethylsulfonyl)imide (2000)

Abstract The electrochemically stable and relatively high conductive room temperature molten salts (RTMS) have been obtained with the use of small ammonium cations such as methoxymethyltrimethylammonium and bis(trifluoromethylsulfonyl)imide. The RTMS showed high conductivity (4.7 mS cm−1 at 25 °C) which is the highest value of all the ammonium based RTMS reported so far.
Improved Secretory Production of the Sweet-Tasting Protein, Brazzein, in <i>Kluyveromyces lactis</i> (2016)

Brazzein is an intensely sweet protein with high stability over a wide range of pH values and temperatures, due to its four disulfide bridges. Recombinant brazzein production through secretory expression in Kluyveromyces lactis is reported, but is inefficient due to incorrect disulfide formation, which is crucial for achieving the final protein structure and stability. Protein disulfide bond formation requires protein disulfide isomerase (PDI) and Ero1p. Here, we overexpressed KlPDI in K. lactis or treated the cells with dithiothreitol to overexpress KlERO1 and improve brazzein secretion. KlPDI and KlERO1 overexpression independently increased brazzein secretion in K. lactis by 1.7-2.2- and 1.3-1.6-fold, respectively. Simultaneous overexpression of KlPDI and KlERO1 accelerated des-pE1M-brazzein secretion by approximately 2.6-fold compared to the previous system. Moreover, intracellular misfolded/unfolded recombinant des-pE1M-brazzein was significantly decreased. In conclusion, increased KlPDI and KlERO1 expression favors brazzein secretion, suggesting that correct protein folding may be crucial to brazzein secretion in K. lactis.
Work holding assessment of an UV adhesive and fixture design method (2019)

Abstract Adhesive work holding can be used to minimize clamping distortion and provide greater access to a work piece during machining. This paper proposes shear and tensile strength criteria to evaluate the work holding strength of adhesive grippers and definition of a strength safety coefficient of adhesive grippers. It also demonstrates a case study of work holding design with an UV adhesive for a grinding process based on a strength criteria explained in the paper. A test rig has been designed and manufactured to assess the capability of an adhesive work holding material. Tests include measurement of strength and repeatability of adhesion under different film thicknesses, curing times and pre-cleaning methods. The test shows the strength repeatability is less than ± 20%, which is good enough for many work holding applications. A shear-tensile combined strength can be evaluated by the strength sphere in a fixture design of a specific part geometry for production by the combined safety coefficient. Following the test rig assessment, a fixture has been designed with 3 grippers to demonstrate the adhesive for a grinding process with a simple part geometry. The method has a high potential for application in industry, and is not limited to the given part geometry and machining method. The grinding test shows that the adhesive work holding is strong enough for the application and that similar results can be expected for milling and turning with a good gripper arrangement.
Macrophage Colony-Stimulating Factor (M-CSF) in Plasma and CSF of Patients with Mild Cognitive Impairment and Alzheimers Disease (2010)

Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that activates microglial cells, involved in phagocytosis of amyloid-beta (Abeta) in the brain. In the present study, we found in 50 patients with Alzheimer's disease (AD) significantly increased M-CSF plasma levels compared to 22 patients with mild cognitive impairment (MCI) and 35 age-matched healthy controls. In contrast, MCI patients showed significantly decreased M-CSF levels in cerebrospinal fluid (CSF) compared to AD patients and 20 patients with other non-inflammatory neurological disease (NIND). Analyzing the impact of Beta-amyloid 1-42 (Abeta 1-42), tau protein and M-CSF for differentiation between the groups we found that M-CSF, but not Abeta 1-42 and tau-protein is a significant parameter for distinction between MCI and NIND patients with 68.8% sensitivity and 75.0% specificity. M-CSF CSF levels < or = 357.8 pg/ml yielded 73.7% sensitivity and 75.0% specificity for diagnosing MCI patients in comparison with control subjects. In conclusion, our data indicate that M-CSF in CSF could be a putative biomarker for MCI.
Development of a facile antibody–drug conjugate platform for increased stability and homogeneity (2016)

Despite the advances in the design of antibody-drug conjugates (ADCs), the search is still ongoing for novel approaches that lead to increased stability and homogeneity of the ADCs. We report, for the first time, an ADC platform technology using a platinum(ii)-based linker that can re-bridge the inter-chain cysteines in the antibody, post-reduction. The strong platinum-sulfur interaction improves the stability of the ADC when compared with a standard maleimide-linked ADC thereby reducing the linker-drug exchange with albumin significantly. Moreover, due to the precise conserved locations of cysteines, both homogeneity and site-specificity are simultaneously achieved. Additionally, we demonstrate that our ADCs exhibit increased anticancer efficacy <i>in vitro</i> and <i>in vivo</i>. The Pt-based ADCs can emerge as a simple and exciting proposition to address the limitations of the current ADC linker technologies.
Filtering Scheme for ROI Coding by Dynamic Range Compression and Updating Source Picture Filter (2016)

The region of interest (ROI) coding, which compresses background region more strongly than ROI do, is valuable technology in restricted communication band and storage capacity. This paper proposes filtering scheme which reduces bits by filtering background region in order to support efficient ROI coding in devices without built-in function of ROI coding. In particular, dynamic range compression (DRC) filter and updating source picture (USP) filter are added to a low-pass filter, which has been used for conventional filtering scheme. The DRC filter compresses dynamic range by down-scaling to all pixels. The USP filter measures distance between current and previous picture by a block, and then overwrites the block of the current picture when the distance is smaller than predetermined threshold. Experimental results show that the proposed filtering scheme reduces bit-rate by half compared to the conventional low-pass filter as PSNR-Y of background region is about 30 dB. Compared to uniform quality coding, the proposed filtering scheme reduces bit-rate by 62%. These results promise to cut down on cost of communication and storage.
Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2 (2004)

Human ATP-binding cassette G2 (ABCG2, also known as mitoxantrone resistance protein, breast cancer-resistance protein, ABC placenta) is a member of the superfamily of ATP-binding cassette (ABC) transporters that have a wide variety of substrates. Overexpression of human ABCG2 in model cancer cell lines causes multidrug resistance by actively effluxing anticancer drugs. Unlike most of the other ABC transporters which usually have two nucleotide-binding domains and two transmembrane domains, ABCG2 consists of only one nucleotide-binding domain followed by one transmembrane domain. Thus, ABCG2 has been thought to be a half-transporter that may function as a homodimer. In this study, we characterized the oligomeric feature of human ABCG2 using non-denaturing detergent perfluoro-octanoic acid and Triton X-100 in combination with gel filtration, sucrose density gradient sedimentation, and gel electrophoresis. Unexpectedly, we found that human ABCG2 exists mainly as a tetramer, with a possibility of a higher form of oligomerization. Monomeric and dimeric ABCG2 did not appear to be the major form of the protein. Further immunoprecipitation analysis showed that the oligomeric ABCG2 did not contain any other proteins. Taken together, we conclude that human ABCG2 likely exists and functions as a homotetramer.
Ethanol-Assisted Synthesis of BaZr<sub><i>x</i></sub>Ti<sub>1−<i>x</i></sub>O<sub>3</sub> Ferroelectric Thin Film under Low-Temperature Conditions (2008)

Nanocrystalline ferroelectric BaTi0.8Zr0.2O3 thin films were prepared by the sol–gel−ethanol thermal technique on Pt(111)/Ti/SiO2/Si(111) substrate under low-temperature conditions. Their structural characteristics and surface morphology were examined by X-ray diffraction and scanning electron microscopy, respectively. The dielectric constant varied from 144 to 115, and the loss tangent varied from 0.08 to 0.04 in the range of 1 kHz to 1 MHz. Leakage current density of 1.5 × 10−5A/cm2 was observed at 300 K with 235 kV/cm of applied electric field.
Transition Metal Carbides and Nitrides as Electrode Materials for Low Temperature Fuel Cells (2009)

Transition metal carbides (TMCs) and transition metal nitrides (TMNs) have attracted attention as promising electrocatalysts that could replace noble metals of high price and limited supply. Relative to parent metals, TMC and TMN behave like noble metals for electrochemical reactions such as oxidation of hydrogen, CO and alcohols, and reduction of oxygen. When TMC and TMN are combined with other metals, the electrocatalytic synergy is often observed in electrochemical reactions. Thus, combinations with a minute amount of Pt or even non-Pt metals give performance comparable to heavily loaded Pt-based electrocatalysts for low temperature fuel cells. It appears that TMC based electrocatalysts are more active as anode catalysts for oxidation of fuels, whereas TMN based catalysts are more active for cathode catalysts for oxygen reduction and more stable.
Prospective Evaluation of Topical Antibiotics for Preventing Infections in Uncomplicated Soft‐tissue Wounds Repaired in the ED (1995)

The use of topical antibiotics resulted in significantly lower infection rates than did the use of a petrolatum control. BAC and NEO had the lowest wound infection rates.
Electrophoretic Deposition Behavior of Chitosan Biopolymer as a Function of Solvent Type (2015)

The influence of three different solvents including lactic acid, formic acid, and acetic acid on the constant-voltage electrodeposition behavior of chitosan biopolymer was investigated. In this regard, charge density, viscosity, and some molecular parameters of chitosan solutions in aqueous acids were studied. The mechanism of chitosan film formation was investigated by fitting the current density–time experimental data to the Pierce and Miskovic film growth models. It was found that solvents have a significant influence on the molecular structure and electrodeposition behavior of chitosan. Using formic acid as the solvent caused the best electrophoretic mobility and resulted in a less porous film compared to acetic acid and lactic acid.
Fluid Handling Industry Update: M&A Activity (2018)

The 2018 fluid handling industry deal activity started at a near record pace with 26 transactions in Q1 but slowed significantly in Q2 with only ten announced transactions, which is the second lowest level of deal activity in the last four years. So far (through August), Q3 deal volume appears to be on pace or slightly ahead of Q3 2017. This pattern is consistent with reports of general M&A activity year to date but seems inconsistent with the high level of interest that both strategic and private equity buyers continue to show in pursuing quality acquisitions in the fluid handling space.
Selective<i>O</i>-Alkylation of 2-Naphthol using Phosphonium-Based Ionic Liquid as the Phase Transfer Catalyst<sup>†</sup> (2010)

The selective preparation of O-alkylated aromatic products from substituted phenol and naphthols is challenging. The O-alkylation of 2-naphthol with benzyl chloride has been studied in this work using phosphonium-based ionic liquids as catalysts such as trihexyl(tetradecyl)phosphonium chloride (THTDPC), trihexyl(tetradecyl)phosphonium bromide (THTDPB), trihexyl(tetradecyl)phosphonium decanoate (THTDPD), and trihexyl(tetradecyl)phosphonium hexafluorophosphate (THTDPH). This is a liquid−liquid phase-transfer-catalysed reaction with reuse of catalyst. The effects of various parameters such as agitation speed, various phosphonium-based ionic liquids, phase volume ratio, catalyst concentration, NaOH concentration, mole ratio of starting materials, and temperature were studied systematically to understand the conversion patterns and the selectivity of the desired product. A mechanism of the reaction and a kinetic model are proposed.