gebhart/patrepeval huggingface dataset:
A Smart Safety Helmet using IMU and EEG sensors for worker fatigue detection (2014)

It is known that head gesture and brain activity can reflect some human behaviors related to a risk of accident when using machine-tools. The research presented in this paper aims at reducing the risk of injury and thus increase worker safety. Instead of using camera, this paper presents a Smart Safety Helmet (SSH) in order to track the head gestures and the brain activity of the worker to recognize anomalous behavior. Information extracted from SSH is used for computing risk of an accident (a safety level) for preventing and reducing injuries or accidents. The SSH system is an inexpensive, non-intrusive, non-invasive, and non-vision-based system, which consists of an Inertial Measurement Unit (IMU) and dry EEG electrodes. A haptic device, such as vibrotactile motor, is integrated to the helmet in order to alert the operator when computed risk level (fatigue, high stress or error) reaches a threshold. Once the risk level of accident breaks the threshold, a signal will be sent wirelessly to stop the relevant machine tool or process.
Superconducting materials processing (1995)

The effects of materials processing on the properties and behavior of high temperature yttrium barium copper oxide (YBCO) superconductors were investigated. Electrical, magnetic, and structural characteristics of thin films (300 nm) YBA2CU3O(delta) structures grown by pulsed laser deposition on LaAlO3 and SrTiO3 substrates were used to evaluate processing. Pole projection and thin film diffraction measurements were used to establish grain orientation and verify structural integrity of the samples. Susceptibility magnetization, and transport measurements were used to evaluate the magnetic and electrical transport properties of the samples. Our results verified that an unfortunate consequence of processing is inherent changes to the internal structure of the material. This effect translates into modifications in the properties of the materials, and undesired feature that makes it very difficult to consistently predict material behavior. The results show that processing evaluation must incorporate a comprehensive understanding of the properties of the materials. Future studies will emphasize microstructural characteristics of the materials, in particular, those microscopic properties that map macroscopic behavior.
Antibodies Against Glutathione S-Transferase T1 (GSTT1) in Patients With GSTT1 Null Genotype as Prognostic Marker: Long-Term Follow-Up After Liver Transplantation (2007)

An objective to improve the evolution of transplants is to identify risk biomarkers of morbidity and loss of allograft. In liver transplant (LTX) recipients, an association has been demonstrated between the presence of mismatch for glutathione S-transferase T1 (GSTT1) and the development of de novo immune hepatitis (IH). In 419 LTX patients we analyzed, for a period of 1 to 14 years, the development of "atypical" autoantibodies directed against GSTT1 and their relationship with the mismatch for GSTT1 genotype and with the risk for developing de novo IH. A total of 6.9% LTX recipients had "atypical" autoantibodies and 24 showed mismatch (recipient/donor) for GSTT1 genotype. From this last group, up to 70% developed de novo IH and graft dysfunction after LTX (95% confidence interval: 17.4-37.5 months). In LTX recipients with a GSTT1 null genotype, the evaluation of "atypical" autoantibodies is useful for monitoring the development of de novo IH.
Mechanistic Study on Hydrogen Spillover onto Graphitic Carbon Materials (2007)

We present a systematic study on the possible mechanisms of hydrogen spillover onto several carbon-based materials using density functional theory (DFT). Adsorption and diffusion of atomic hydrogen on a graphene sheet, single-walled carbon nanotubes, and a polyaromatic compound, hexabenzocoronene, were calculated, and the potential energies along the selected adsorption and diffusion minimum energy pathways were mapped out. We show that the migration of H atoms from a Pt cluster catalyst to the substrates is facile at ambient conditions with a small energy barrier, although the process is slightly endothermic, and that the H atoms can be either physisorbed or chemisorbed on carbon surfaces. Our results indicate that diffusion of H atoms in a chemisorbed state is energetically difficult since it requires C−H bond breaking and hydrogen spillover would occur likely via physisorption of H atoms. The curvature of the carbon materials is found to have a pronounced influence on the mobility of H atoms. The role of the “bridge” materials used in experiments is also discussed.
The Effects of Physical and Psychological Stress on the Gastrointestinal Tract: Lessons from Animal Models (2008)

Physical and psychological stresses are widely accepted as triggers and / or modifiers of the clinical course of diverse gastrointestinal disorders such as peptic ulcer, irritable bowel syndrome or inflammatory bowel disease. Growing experimental evidence from a variety of models such as immobilization, thermal injury or early maternal deprivation in laboratory animals uniformly supports the ability of stress to induce the development of gastric ulcers, altered gastrointestinal motility and ion secretion, and increased intestinal permeability leading to the passage of antigens to the lamina propria and bacterial translocation. Stress can also synergize with other pathogenic factors such as Helicobacter pylori, non-steroidal anti-inflammatory drugs or colitis-inducing chemicals to produce gastrointestinal disease. The brain-gut axis provides the anatomical basis through emotions and environmental influences modulate the gastrointestinal function through the regulation of gastrointestinal immune system and mucosal inflammation; in this sense, mucosal mast cells - at cellular level - and corticotropin releasing factor (CRF) - at molecular level - seem to play a crucial role. On the other hand, an array of adaptive responses have been evolved in order to maintain the homeostasis and to ensure the survival of the individual. In the gut mucosa anti-inflammatory pathways counteract the deleterious effect of the stressful stimuli on the gastrointestinal homeostasis. In the present review we discuss the several experimental approaches used to mimic human stressful events or chronic stress in laboratory animals, the evidence of stress-induced gastrointestinal inflammation and dysfunction derived from them, and the involved cellular and molecular mechanisms that are being discovered during the last years.
A role for type I signal peptidase in <i>Staphylococcus aureus</i> quorum sensing (2007)

The Staphylococcus aureus Agr quorum-sensing system modulates the expression of extracellular virulence factors. The Agr system is controlled by an autoinducing peptide (AIP) molecule that is secreted during growth. In the AIP biosynthetic pathway, two proteolytic events are required to remove the leader and tail segments of AgrD, the peptide precursor of AIP. The only protein known to be involved in this pathway is AgrB, a membrane endopeptidase that removes the AgrD carboxy-tail. We designed a synthetic peptide substrate and developed an assay to detect peptidases that can remove the N-terminal leader of AIP. Several peptidase activities were detected in S. aureus extracts and these activities were present in both wild-type and agr mutant strains. Only one of these peptidases cleaved in the correct position and all properties of this enzyme were consistent with type I signal peptidase. Subsequent cloning and purification of the two known S. aureus signal peptidases, SpsA and SpsB, demonstrated that only SpsB catalysed this activity in vitro. To investigate the role of SpsB in AIP biosynthesis, SpsB peptide inhibitors were designed and characterized. The most effective inhibitor blocked SpsB activity in vitro and showed antibacterial activity against S. aureus. Importantly, the inhibitor reduced expression of an Agr-dependent reporter and inhibited AIP production in S. aureus, indicating a role for SpsB in quorum sensing.
Nebula: Distributed Edge Cloud for Data Intensive Computing (2014)

Centralized cloud infrastructures have become the de-facto platform for data-intensive computing today. However, they suffer from inefficient data mobility due to the centralization of cloud resources, and hence, are highly unsuited for dispersed-data-intensive applications, where the data may be spread at multiple geographical locations. In this paper, we present Nebula: a dispersed cloud infrastructure that uses voluntary edge resources for both computation and data storage. We describe the lightweight Nebula architecture that enables distributed data-intensive computing through a number of optimizations including location-aware data and computation placement, replication, and recovery. We evaluate Nebula's performance on an emulated volunteer platform that spans over 50 PlanetLab nodes distributed across Europe, and show how a common data-intensive computing framework, MapReduce, can be easily deployed and run on Nebula. We show Nebula MapReduce is robust to a wide array of failures and substantially outperforms other wide-area versions based on a BOINC like model.
The Effect of Topical Infliximab on Corneal Neovascularization in Rabbits (2012)

The application of infliximab is expected to effectively inhibit corneal neovascularization. Further clinical studies are necessary.
Practical SVBRDF capture in the frequency domain (2013)

Spatially-varying reflectance and small geometric variations play a vital role in the appearance of real-world surfaces. Consequently, robust, automatic capture of such models is highly desirable; however, current systems require either specialized hardware, long capture times, user intervention, or rely heavily on heuristics. We describe an acquisition setup that utilizes only portable commodity hardware (an LCD display, an SLR camera) and contains no moving parts. In particular, a laptop screen can be used for illumination. Our setup, aided by a carefully constructed image formation model, automatically produces realistic spatially-varying reflectance parameters over a wide range of materials from diffuse to almost mirror-like specular surfaces, while requiring relatively few photographs. We believe our system is the first to offer such generality, while requiring only standard office equipment and no user intervention or parameter tuning. Our results exhibit a good qualitative match to photographs taken under novel viewing and lighting conditions for a range of materials.
High-Voltage trenched rectifiers for Smart Power technology (2008)

High-voltage junction and Schottky trenched power rectifiers (HV-JTPR and STPR) are fabricated and analyzed in this paper for 70 V to 100 V reverse voltage applications. Resulting from their combination, an innovative hybrid device (HTPR), with alternated Schottky/Junction fingers, is a proper solution to control the trade-off between the losses in forward and reverse modes.
Die Wahrnehmung der Pädagogik Johann Friedrich Herbart in Polen (2017)

The article shows the development of Polish interests in the pedagogical mind of J. F. Herbart. In this work we chronologically presented the most important Polish publications on Herbart we drew attention to the change of its perception in different historical periods. There is no doubt that a large part of Polish authors esteem the educational Herbart and tried to popularize his ideas among Polish teachers. It is understood that the greatest interest in ‘herbartyzmem’ was in the nineteenth century but it declined sharply in the next century. This was associated with the development of new educational systems. The article is an important contribution to a better understanding of the reception of the German educational thought in other countries.
Discovery of <i>N</i>-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1<i>H</i>-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors (2018)

While the treatment of gastrointestinal stromal tumors (GISTs) has been revolutionized by the application of targeted tyrosine kinase inhibitors capable of inhibiting KIT-driven proliferation, diverse mutations to this kinase drive resistance to established therapies. Here we describe the identification of potent pan-KIT mutant kinase inhibitors that can be dosed without being limited by the tolerability issues seen with multitargeted agents. This effort focused on identification and optimization of an existing kinase scaffold through the use of structure-based design. Starting from a series of previously reported phenoxyquinazoline and quinoline based inhibitors of the tyrosine kinase PDGFRα, potency against a diverse panel of mutant KIT driven Ba/F3 cell lines was optimized, with a particular focus on reducing activity against a KDR driven cell model in order to limit the potential for hypertension commonly seen in second and third line GIST therapies. AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalized predominantly by the interaction of water molecules with the protein and ligand in the active site, and its kinome selectivity is similar to the best of the approved GIST agents. This compound demonstrates excellent cross-species pharmacokinetics, shows strong pharmacodynamic inhibition of target, and is active in several in vivo models of GIST.
Structural and Chemical Properties of Silyl Radicals (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural and Chemical Properties of Silyl RadicalsChryssostomos ChatgilialogluCite this: Chem. Rev. 1995, 95, 5, 1229–1251Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/cr00037a005https://doi.org/10.1021/cr00037a005research-articleACS PublicationsRequest reuse permissionsArticle Views4974Altmetric-Citations369LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Investigation of<i>in vivo</i>measurement of cerebral cytochrome-<i>c</i>-oxidase redox changes using near-infrared spectroscopy in patients with orthostatic hypotension (2006)

We have previously used a continuous four-wavelength near-infrared spectrometer to measure changes in the cerebral concentrations of oxy-haemoglobin (Delta[HbO(2)] and deoxy-haemoglobin (Delta[HHb]) during head-up tilt in patients with primary autonomic failure. The measured changes in light attenuation also allow calculation of changes in the concentration of oxidized cytochrome-c-oxidase (Delta[(ox)CCO]), and this paper analyses the Delta[(ox)CCO] during the severe episodes of orthostatic hypotension produced by this experimental protocol. We studied 12 patients during a passive change in position from supine to a 60 degrees head-up tilt. The challenge caused a reduction in mean blood pressure of 59.93 (+/-26.12) mmHg (Mean (+/-SD), p < 0.0001), which was associated with a reduction in the total concentration of haemoglobin (Delta[HbT] = Delta[HbO(2)] + Delta[HHb]) of 5.02 (+/-3.81) microM (p < 0.0001) and a reduction in the haemoglobin difference concentration (Delta[Hb(diff)] = Delta[HbO(2)] - Delta[HHb]) of 14.4 (+/-6.73) microM (p < 0.0001). We observed a wide range of responses in Delta[(ox)CCO]. Six patients demonstrated a drop in Delta[(ox)CCO] (0.17 +/- 0.15 microM); four patients demonstrated no change (0.01 +/- 0.12 microM) and two patients showed an increase in Delta[(ox)CCO] (0.21 +/- 0.01 microM). Investigation of the association between the changes in concentrations of haemoglobin species and the Delta[(ox)CCO] for each patient show a range of relationships. This suggests that a simple mechanism for crosstalk, which might produce artefactual changes in [(ox)CCO], is not present between the haemoglobin and the (ox)CCO NIRS signals. Further investigation is required to determine the clinical significance of the changes in [(ox)CCO].
Advanced Surface Functionalization of Periodic Mesoporous Silica:  Kinetic Control by Trisilazane Reagents (2006)

The surface reactions of mesoporous silica MCM-41 with a series of new trisilylamines (trisilazanes) (SiHMe2)2NSiMe2R and (SiMe2Vin)2NSiMe2R (R = indenyl, norpinanyl, chloropropyl, 3-(N-morpholin)propyl; Vin = vinyl), disilylalkylamine (SiHMe2)iPrNSiMe2(CH2)3Cl, and monosilyldialkylamines Me2NSiMe2R (R = indenyl, chloropropyl, 3-(N-morpholin)propyl) were investigated. 1H, 13C, and 29Si MAS NMR spectroscopy, nitrogen adsorption/desorption, infrared spectroscopy, and model reactions with calix[4]arene as a mimic for an oxo surface were used to clarify the chemical nature of surface-bonded silyl groups. The trisilylamines exhibited a comparatively slow surface reaction, which allowed for the adjustment of the amount of silylated and nonreacted SiOH groups and led to a stoichiometric distribution of surface functionalities. The 2:1 integral ratio of SiHMe2 and SiMe2R moieties of such trisilazanes was found to be preserved on the silica surface as indicated by microanalytical as well as 13C and 29Si MAS NMR spectroscopic data of the hybrid materials. For example, the reaction of MCM-41 with (SiHMe2)2NSiMe2(CH2)3Cl, (SiHMe2)iPrNSiMe2(CH2)3Cl, and Me2NSiMe2(CH2)3Cl provided bi- and monofunctional hybrid materials with one-third, one-half, or all chemically accessible silanol groups derivatized by chloropropyl groups, respectively. Thus, a molecular precursor strategy was developed to efficiently control the relative amount of three different surface species, SiHMe2 (or SiVinMe2), SiMe2R, and SiOH, in a single reaction step. The reaction behavior of indenyl-substituted monosilazanes and trisilazanes (R = Ind) with calix[4]arene proved that the indenyl substituent can act as a leaving group forming a dimethylsilyl species, which is anchored bipodally on the silica surface, that is, via two Si-O bonds.
A new concept of a high-current power module allowing paralleling of many SiC devices assembled exploiting conventional packaging technologies (2016)

We present a new concept of a high-current SiC power module with the fast switching capability based on a stacked-ceramic-substrate structure. This approach enables to parallel many small area SiC devices in a housing of a Si half-bridge module. The internal design of the module - concept demonstrator was optimized using electromagnetic simulations in order to minimize stray inductance and balanced current sharing. The prototype was assembled exploiting conventional packaging technologies. Performance of the assembled module was tested by a double-pulse measurement test in order to determine switching losses and verify simulated stray inductance.
Resveratrol Suppresses Expression of VEGF by Human Retinal Pigment Epithelial Cells: Potential Nutraceutical for Age-related Macular Degeneration. (2014)

Age-related macular degeneration (AMD) is a sight threating retinal eye disease that affects millions of aging individuals world-wide. Choroid-retinal pigment epithelium (RPE)-neuroretina axis in the posterior compartment of the eye is the primary site of AMD pathology. There are compelling evidence to indicate association of vascular endothelial growth factors (VEGF) to AMD. Here, we report the inhibitory actions of resveratrol (RSV) on inflammatory cytokine, TGF-β and hypoxia induced VEGF secretion by human retinal pigment epithelial cells (HRPE). HRPE cultures prepared from aged human donor eyes were used for the studies in this report. HRPE secreted both VEGF-A and VEGF-C in small quantities constitutively. Stimulation with a mixture of inflammatory cytokines (IFN-γ, TNF-α, IL-1β), significantly increased the secretion of both VEGF-A and VEGF-C. RSV, in a dose dependent (10-50 uM) manner, suppressed VEGF-A and VEGF-C secretion induced by inflammatory cytokines significantly. RT-PCR analysis indicated that effects of RSV on VEGF secretion were possibly due to decreased mRNA levels. TGF-β and cobalt chloride (hypoxia mimic) also upregulated HRPE cell production of VEGF-A, and this was inhibited by RSV. In contrast, RSV had no effect on anti-angiogenic molecules, endostatin and pigment epithelial derived factor secretion. Studies using an in vitro scratch assay revealed that wound closure was also inhibited by RSV. These results demonstrate that RSV can suppress VEGF secretion induced by inflammatory cytokines, TGF-β and hypoxia. Under pathological conditions, over expression of VEGF is known to worsen AMD. Therefore, RSV may be useful as nutraceutical in controlling pathological choroidal neovascularization processes in AMD.
A single set of low intensity resistance exercise immediately following high intensity resistance exercise stimulates growth hormone secretion in men. (2003)

These results suggests that a high intensity, low volume training protocol to induce neural adaptation resulted in little GH response, but GH secretion was increased by performing a single set of low intensity resistance exercise at the end of a series of high intensity resistance sets.
Experimental study of impact oscillator with one-sided elastic constraint (2007)

In this paper, extensive experimental investigations of an impact oscillator with a one-sided elastic constraint are presented. Different bifurcation scenarios under varying the excitation frequency near grazing are shown for a number of values of the excitation amplitude. The mass acceleration signal is used to effectively detect contacts with the secondary spring. The most typical recorded scenario is when a non-impacting periodic orbit bifurcates into an impacting one via grazing mechanism. The resulting orbit can be stable, but in many cases it loses stability through grazing. Following such an event, the evolution of the attractor is governed by a complex interplay between smooth and non-smooth bifurcations. In some cases, the occurrence of coexisting attractors is manifested through discontinuous transition from one orbit to another through boundary crisis. The stability of non-impacting and impacting period-1 orbits is then studied using a newly proposed experimental procedure. The results are compared with the predictions obtained from standard theoretical stability analysis and a good correspondence between them is shown for different stiffness ratios. A mathematical model of a damped impact oscillator with one-sided elastic constraint is used in the theoretical studies.