gebhart/patrepeval huggingface dataset:
CXCR4 Inhibitors: Tumor Vasculature and Therapeutic Challenges (2012)

CXCL12, also known as SDF-1, is the single natural ligand for chemokine receptors CXCR4 and CXCR7. CXCL12 has angiogenic properties in normal endothelial tissue and is involved in the outgrowth and metastasis of CXCR4 expressing tumors. Recent investigations have indicated that CXCL12 levels increase after chemo- and anti- VEGF therapy, favouring recurrences. The blockade of CXCL12/CXCR4 axis has emerged as a potential additional or alternative target for neo-adjuvant treatments. We have reviewed recent patent applications between 2008 and 2011 in tumor angiogenesis and the most clinical data supporting the potential use of anti-CXCR4 agents in this field. Among these, AMD3100, also known as Plerixaform (Mozobil by Genzyme), is approved for stem cell mobilisation in patients with leukaemia, while BKT140 (Emory University), POL6326 (Polyphor Ag) and TG-0054 (ChemoCentryx) are currently in clinical trials in combination with chemotherapy for multiple myeloma and leukaemia. The aptamer Nox-A12 (Noxxon) is in trials for chronic lymphatic leukaemia treatment. MSX-122 (Metastatix) is in Phase I trials for solid tumor treatment, while CXCR7-specific inhibitor CCX2066 (ChemoCentryx) is still in preclinical studies. We have also considered other strategies, such RNA interference and miRNA, which could be tested for solid tumor adjuvant therapy.
[A phase II study of CPT-11, a camptothecin derivative, in patients with primary lung cancer. CPT-11 Cooperative Study Group]. (1991)

A Phase II study of CPT-11, a new camptothecin, was performed in patients with primary lung cancer. Patients with previously untreated non-small cell carcinomas (group A), or previously treated non-small cell carcinomas (group B), and with small cell carcinomas (group C), were enrolled in this study. CPT-11 was given at a dose of 100 mg/m2 i.v. infusion once a week for three weeks or more. Out of 153 patients enrolled, 128 (A: 67; B: 26; C: 35) were assessed to be evaluable for response by an extramural review committee. Response rates were 34.3% (23/67) for A, 0% (0/26) for B and 37.1% (13/35) for C. The response rate was 50% for previously untreated patients (4/8), and 33.3% for previously treated patients (9/27) including 2 complete responses in the group C. Major toxicities were leukopenia, nausea/vomiting, diarrhea, anorexia and alopecia. Leukopenia and diarrhea were considered to be dose limiting toxicities, but they were reversible. It was, however, suggested that some patients should be monitored carefully for severe reactions and delay in recovery. The results showed that CPT-11 was highly effective against non-small cell and small cell carcinomas of the lung.
Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle (1995)

A group of specialized mesenchymal cells located at the root of the mammalian hair follicle, known as the follicular or dermal papillary cells, are involved in regulating the hair cycle, during which keratinocytes of the lower follicle undergo proliferation, degeneration and regrowth. Using the arbitrarily primed-PCR approach, we have identified a 1.3 kb messenger RNA that is present in large quantities in cultured rat follicular papillary cells, but not in skin fibroblasts. This mRNA encodes nexin 1, a potent protease inhibitor that can inactivate several growth-modulating serine proteases including thrombin, urokinase and tissue plasminogen activator. In situ hybridization showed that nexin 1 message is accumulated in the follicular papilla cells of anagen follicles, but is undetectable in keratinocytes or other skin mesenchymal cells. In addition, nexin 1 message level varies widely among several immortalized rat vibrissa papillary cell lines, and these levels correlate well with the reported abilities of these cell lines to support in vivo follicular reconstitution. These results suggest a possible role of nexin 1 in regulating hair follicular growth.
A 10-b 100-Msample/s pipelined subranging BiCMOS ADC (1993)

A 10-b 100-Msample/s pipelined subranging analog-digital converter (ADC) has been achieved. Such technologies as a pipelined subranging scheme, a track-and-hold amplifier (THA) with current-switching sampling gates, a 94-dB dc open-loop gain, a 335-MHz unity-gain frequency op amp, and a carry-look-ahead adder for digital error correction are presented. The 3.4-mm*5.6-mm ADC chip was fabricated using a 0.8- mu m BiCMOS process and operates with 950-mW power dissipation from a single -5-V power supply.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Growth and Property Characterization of Epitaxial MAX-Phase Thin Films from the Ti<sub>n+1</sub>(Si, Ge, Sn)C<sub>n</sub> Systems (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Eltrombopag for the treatment of chronic immune (idiopathic) thrombocytopenic purpura. (2009)

The US FDA approved eltrombopag for use among certain patients with chronic ITP based upon demonstration of a favorable risk-to-benefit profile, where the major benefit pertained to demonstration of a clinically important increase in blood platelets among a population of patients relatively refractory to prior therapies.
Characterization of Rigid Polyurethane Foam Prepared from Recycling of PET Waste (2015)

Poly (ethylene terephthalate) (PET) waste bottles were recycled to prepare RPUFs (rigid polyurethane foams) by using propylene glycol (PG) in different glycol/polymer molar ratios. The glycolysis products were characterized, after that, they reacted with poly methylene diphenyl diisocyanate (PMDI) in the presence of blowing, co-blowing and second blowing agents to produce the RPUFs. The prepared foams were characterized and compared to foam that is produced by original polyol. It was found that the glycolysis products have possibility for the fabrication of RPUFs with proper properties depending on the blowing agent type and density, also they have similar thermal stability compared to that one produced by original polyol. This may provide an advantage in the future planning for recycling of PET bottles to enhance the mechanical and thermal properties of PU.
Globally optimising formant tracker using generalised centroids (1987)

An algorithm is presented which uses a method of generalised centroid estimation to describe a spectral distribution as a fixed number of peaks. The technique offers a useful alternative method of formant tracking for speech recognition. Results are included which show the performance of the algorithm.
Self-pulsation in two-section DFB semiconductor lasers and its synchronization to an external signal (1998)

A model of self-pulsation in two-section distributed feedback (DFB) lasers without a saturable absorber is developed by using generalized rate equations. The introduction of an effective differential gain in our model allows us to take into consideration both material and structural effects. The self-pulsation conditions are derived from a linear stability analysis. A mechanism based on a negative effective differential gain is proposed to explain the origin of self-pulsation in such lasers. By considering an injected optical signal, the optical synchronization of self-pulsating lasers is studied using nonlinear simulations. This leads to the determination of some locking-range properties, which are then compared to experimental and analytical results.
Olfactory System and Demyelination (2013)

Within the central nervous system, the olfactory system represents one of the most exciting scenarios since it presents relevant examples of long-life sustained neurogenesis and continuous axonal outgrowth from the olfactory epithelium with the subsequent plasticity phenomena in the olfactory bulb. The olfactory nerve is composed of nonmyelinated axons with interesting ontogenetic interpretations. However, the centripetal projections from the olfactory bulb are myelinated axons which project to more caudal areas along the lateral olfactory tract. In consequence, demyelination has not been considered as a possible cause of the olfactory symptoms in those diseases in which this sense is impaired. One prototypical example of an olfactory disease is Kallmann syndrome, in which different mutations give rise to combined anosmia and hypogonadotropic hypogonadism, together with different satellite symptoms. Anosmin-1 is the extracellular matrix glycoprotein altered in the X-linked form of this disease, which participates in cell adhesion and migration, and axonal outgrowth in the olfactory system and in other regions of the central nervous system. Recently, we have described a new patho-physiological role of this protein in the absence of spontaneous remyelination in multiple sclerosis. In the present review, we hypothesize about how both main and satellite neurological symptoms of Kallmann syndrome may be explained by alterations in the myelination. We revisit the relationship between the olfactory system and myelin highlighting that minor histological changes should not be forgotten as putative causes of olfactory malfunction.
Complex arterial patterning in an anatomical donor (2018)

Case reports of individuals with a single variant or a limited number of localized variants are plentiful; however, systematic, whole-body study of cerebral, axial, and peripheral arterial variants in a single anatomical donor is lacking. This case report describes widespread arterial variants in a single donor. We report several remarkable variants in this case and then, discuss these finding with regards to clinical relevance, prior vascular variant studies and embryologic development. Additionally, combined probability calculations reveal that the probability of possessing this constellation of arterial variants, by chance, is 0.0001. Given this low probability, we hypothesize that our donor had a propensity for developing arterial variants and further, that the presence of multiple variants is related to disruption in vascular developmental pathways during the embryonic period. Such information has direct clinical relevance, particularly during invasive diagnostic and surgical procedures. Keywords: Arterial variant, Vascular variant, Branch variation, Whole-body
Arabidopsis <i>CDKA;1</i>, a <i>cdc2</i> homologue, controls proliferation of generative cells in male gametogenesis (2006)

The protein kinase cdc2 is conserved throughout eukaryotes and acts as a key regulator of the cell cycle. In plants, A-type cyclin-dependent kinase (CDKA), a homologue of cdc2, has a role throughout the cell cycle. Here we show that a loss-of-function mutation in CDKA;1, encoding the only Arabidopsis CDKA, results in lethality of the male gametophyte. Heterozygous plants produced mature siliques containing about 50% aborted seeds, and segregation distortion was observed in paternal inheritance. Microspores normally undergo an asymmetric cell division, pollen mitosis I (PMI), to produce bicellular pollen grains. The larger vegetative cell does not divide, but the smaller generative cell undergoes mitosis, PMII, to form the two sperm cells, thereby generating tricellular pollen grains. The cdka-1 mutant, however, produces mature bicellular pollen grains, consisting of a single sperm-like cell and a vegetative cell, due to failure of PMII. The mutant sperm-like cell is fertile, and preferentially fuses with the egg cell to initiate embryogenesis. As the central cell nucleus remains unfertilized, however, double fertilization does not occur. In heterozygous plants, the embryo is arrested at the globular stage, most likely because of loss of endosperm development, whereas it is arrested at the one- or two-cell stage in presumptive homozygous plants. Thus, CDKA;1 is essential for cell division of the generative cell in male gametogenesis.
Treatment of dyslipidemia with lovastatin and ezetimibe in an adolescent with cholesterol ester storage disease (2005)

These preliminary anecdotal findings in a CESD patient with novel LIPA mutations support the longer term safety of statins in an adolescent patient and provide new data about the potential efficacy and tolerability of ezetimibe in this patient group.
Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics (2020)

Oral vaccination enables pain-free and self-administrable vaccine delivery for rapid mass vaccination during pandemic outbreaks. Furthermore, it elicits systemic and mucosal immune responses. This protects against infection at mucosal surfaces, which may further enhance protection and minimize the spread of disease. The gastrointestinal (GI) tract presents a number of prospective mucosal inductive sites for vaccine targeting, including the oral cavity, stomach, and small intestine. However, currently available oral vaccines are effectively limited to live-attenuated and inactivated vaccines against enteric diseases. The GI tract poses a number of challenges,including degradative processes that digest biologics and mucosal barriers that limit their absorption. This review summarizes the approaches currently under development and future opportunities for oral vaccine delivery to established (intestinal) and relatively new (oral cavity, stomach) mucosal targets. Special consideration is given to recent advances in oral biologic delivery that offer promise as future platforms for the administration of oral vaccines.
A low-cost fail-safe circuit for fault-tolerant control systems (2003)

Commercially available fault-tolerant control systems use high-cost multiprocessor architectures. The circuit we introduce, called RCMP, is the fundamental piece of a strategy intended to add fault-tolerance to industrial control systems using standard personal computers. The strategy is to construct a multiprocessor system to be able to vote on the computation partial results by interconnecting N personal computers. The RCMP is the interface between each computer and the communication channel, and it also performs the voting and the transmission of the obtained result. The RCMP presents a duplicated architecture for fail-safe behaviour and a duplicated communication channel to avoid the single point of failure that a single channel would represent. At the implementation level the RCMP is a PC/XT bus card based on a 8 bit microcontroller that interfaces each computer with a duplicated CAN bus.
La sexualidad y la ética (2003)

espanolLa cultura modula la representacion social que un pueblo tiene sobre el sexo y la sexualidad. Estas percepciones sociales generan estereotipos en torno al sexo reales e irreales que, algunos de ellos, pueden generar problemas. La solucion a estas dificultades puede encontrarse en la etica. La educacion etica puede ayudarnos a ser mas felices y a convivir mejor en general y en lo que a la sexualidad se refiere. En este escrito se plantea la etica y la sexualidad desde un prisma educativo que debe articularse en tres niveles: la educacion afectiva, la formacion de los sistemas psicologicos de comportamiento autonomo y la educacion propiamente etica. EnglishCulture modulates the social representation a people hold on sex and sexuality. These social perceptions give rise to real and unreal stereotypes around sex, some of which may cause problems. The solution to these difficulties may be found in ethics. Ethical education may aid us to be happier and co-exist better in general and as far as sexuality is concerned. This paper looks at ethics and sexuality from an educational standpoint, which must be structured on three levels: affective education, the formation of psychological systems of autonomous behaviour and actual education in ethics itself.
III-V-on-Silicon Integration: From Hybrid Devices to Heterogeneous Photonic Integrated Circuits (2019)

Heterogeneous integration of III-V materials onto silicon photonics has experienced enormous progress in the last few years, setting the groundwork for the implementation of complex on-chip optical systems that go beyond single device performance. Recent advances on the field are expected to impact the next generation of optical communications to attain low power, high efficiency and portable solutions. To accomplish this aim, intense research on hybrid lasers, modulators and photodetectors is being done to implement optical modules and photonic integrated networks with specifications that match the market demands. Similarly, important advances on packaging and thermal management of hybrid photonic integrated circuits (PICs) are currently in progress. In this paper, we report our latest results on hybrid III-V on Si transmitters, receivers and packaged optical modules for high-speed optical communications. In addition, a review of recent advances in this field will be provided for benchmarking purposes.
lncRNA/MicroRNA interactions in the vasculature (2016)

MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains limited. The influence of miRNA on lncRNA function, and the converse, is now beginning to emerge. lncRNA may regulate miRNA function by acting as endogenous sponges to regulate gene expression and miRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-miRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks.
Modulation of extracellular‐matrix synthesized by cultured stromal cells from normal human breast tissue by epidermal growth factor (1990)

A routine, reproducible procedure was developed for the preparation and characterization of stromal cells from normal human breast tissue obtained by reduction mammaplasty. Isolates (n = 15) all exhibited enhanced rates of proliferation, even in the presence of 20% fetal calf serum, when exposed to epidermal growth factor or transforming growth factor a (both 10(-8) M). Cellular responsiveness to these growth factors was consistent with expression of specific surface receptors for epidermal growth factor (approximately 10(4)/cell). In cultures, stromal cells elaborated an extensive, cross-linked, insoluble extracellular matrix which remained firmly associated with the plastic surface of tissue culture ware upon lysis of cells. The insoluble matrix material was analyzed using enzymatic digestion procedures following incorporation of radiolabelled precursors into macromolecular material prior to lysis and preparation. The relative proportion of glycoconjugate (glycopeptides and proteoglycans) and collagenous material present in matrix material was approximately 45% and approximately 55%, respectively, and this was modulated by inclusion of epidermal growth factor into culture medium to approximately 60% and approximately 40%, respectively. Under similar culture conditions stromal cells synthesized twice as much hyaluronate as was produced by control cultures. By use of specific antibody preparations we identified at least four species of glycopeptide present in stromal matrices (namely, fibronectin, laminin, tenascin, and thrombospondin) as well as three types of collagen (types I, III, and IV). The rapid and reproducible procedure for the preparation of radiolabelled insoluble matrix material from normal human breast tissue allows for the study of cellular interaction involving extracellular matrix turnover and degradation.
Experience with Extracorporeal Shock Wave Lithotripsy in the Pediatric Age Group (1987)

No AccessJournal of Urology1 Jun 1987Experience with Extracorporeal Shock Wave Lithotripsy in the Pediatric Age Group Janet E. Smith, and Howard Pollack Janet E. SmithJanet E. Smith More articles by this author , and Howard PollackHoward Pollack More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)75862-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Experience with Extracorporeal Shock Wave Lithotripsy in the Pediatric Age Group." The Journal of Urology, 137(6), p. 282A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 282A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Janet E. Smith More articles by this author Howard Pollack More articles by this author Expand All Advertisement Loading ...
Nutrient Amendment for the Bioremediation of a Chromium-Contaminated Soil by Electrokinetics (2003)

This article presents the results of a preliminary laboratory investigation wherein electrokinetics was used for the delivery of nutrients to metal-reducing micro-organisms in a low permeability clayey soil. In particular, the micro-organisms were used to reduce a toxic and mobile heavy metal (hexavalent chromium or Cr(VI)) to a less toxic and immobile form (trivalent chromium or Cr(III)). Three bench-scale electrokinetic experiments were conducted using kaolin as a model low permeability clayey soil, and the kaolin was artificially contaminated with Cr(VI) at an initial target concentration of 1,000 mg/kg. All the experiments were conducted with a constant electrical voltage gradient of 1.0 V/cm and included a control test without micro-organisms or nutrients, a test with micro-organisms but without nutrients, and a test with micro-organisms and supplemental nutrients, specifically acetate, phosphate, and ammonium. The results showed that acetate and phosphate amendment by electrokinetics was effective because both nutrients electromigrated into the soil. Moreover, the results indicate that employing the micro-organism cultures improved Cr(VI) reduction. These results suggest that nutrient amendment by electrokinetics for the bioremediation of heavy metals has great potential; however, the microbial strains responsible for Cr(VI) reduction must be identified so the electrokinetic system can be engineered to provide the optimal nutrient, pH, and environmental conditions for these strains.