gebhart/patrepeval huggingface dataset:
Coronin 1-Mediated Naive T Cell Survival Is Essential for the Development of Autoimmune Encephalomyelitis (2011)

Autoimmune encephalomyelitis is a disease of the CNS that can develop when an initial peripheral inflammatory stimulus is followed by infiltration and reactivation of T lymphocytes in the CNS. We report a crucial role for coronin 1, which is essential for maintenance of the naive T cell pool, for the development of murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. In the absence of coronin 1, immunization with myelin oligoglycoprotein (MOG(35-55)) peptide largely failed to induce EAE symptoms, despite normal mobilization of leukocyte subsets in the blood, as well as effector cytokine expression comparable with wild-type T cells on polyclonal stimulation. Susceptibility of coronin 1-deficient mice to EAE induction was restored by transfer of wild-type CD4(+) T cells, suggesting that the observed resistance of coronin 1-deficient mice to EAE development is T cell intrinsic. Importantly, although coronin 1-deficient regulatory T cells (Tregs) showed a suppressor activity comparable with wild-type Tregs, Treg depletion failed to restore EAE development in coronin 1-deficient animals. These results suggest a hitherto unrecognized role of naive T cells in the development of autoimmune encephalomyelitis and reveal coronin 1 as a crucial modulator of EAE induction.
Nutrition and Eye Diseases (2010)

e eye is a delicate sensory organ exposed daily to bright light and environmental toxins. Light and toxins such as chemicals and smoke generate free radicals that cause damage in eye tis- sues. !erefore the eye is susceptible to degenerative diseases related to oxidative stress and aging. In macular degeneration, oxidized products of metabolism gradually build up in a layer underneath the retina, eventually causing retinal detachment and blindness. In glaucoma, the intra-ocular pressure builds up due to oxidative stress, causing retinal axons entering the optic nerve to progressively die. In retinitis pigmentosa, rods die from a genetic abnormality and cones progressively die due to oxidative stress. In diabetic retinopathy, high blood sugar causes progressive damage to the retina. High levels of antioxidants such as vitamins C and E in the body are associated with a lower incidence of these diseases, and oral administration of these and other antioxidants reduces oxidative stress and the disease risk. Success is dependent on a sucient level of supplements taken over a sucient duration of time. !ere is abundant evidence that many eye diseases can be e#ectively slowed or prevented using supplements of antioxidants and other essential nutrients at high enough doses.
Use of the ‘Perceptron’ algorithm to distinguish translational initiation sites in<i>E. coli</i> (1982)

We have used a "Perceptron" algorithm to find a weighting function which distinguishes E. coli translational initiation sites from all other sites in a library of over 78,000 nucleotides of mRNA sequence. The "Perceptron" examined sequences as linear representations. The "Perceptron" is more successful at finding gene beginnings than our previous searches using "rules" (see previous paper). We note that the weighting function can find translational initiation sites within sequences that were not included in the training set.
Synthesis of ABO Histo-Blood Group Type V and VI Antigens* (2009)

The ABO histo-blood group antigens have long been of interest to chemists, biochemists, and evolutionary biologists. However, to date, a complete synthesis of all ABO histo-blood group antigens has not been conducted, despite the potential for such a panel to provide a more detailed understanding of the biological roles of these glycan motifs. Here we report the chemical synthesis of the A, B, and H type V and VI antigens in multi-milligramme quantities as part of an overall goal to prepare all 18 A, B, and H antigens. The A and B type V and VI antigens were prepared with a 7-octen-1-yl linker, to enable future conjugation to a protein or solid support. The H type V and VI antigens were prepared as the octyl glycoside, to facilitate detailed enzyme kinetics studies.
TAIM: conflitos socioambientais e estratégias de defesa do território (2010)

Trata-se, neste artigo, de uma situacao de conflito socio-ambiental, entre povoados localizados na Zona Rural do municipio de Sao Luis-MA e grandes empreendimentos industriais, decorrente de formas diferenciadas de percepcao, controle e utilizacao do territorio. O conflito teve inicio a partir do final da decada de 1970, com a instalacao de grandes projetos de desenvolvimento, o que implicou no deslocamento compulsorio de varios povoados e em alteracoes nos ecossistemas e modos de vida dos que ali permaneceram. No inicio de 2001, anunciou-se a instalacao na area de um grande polo siderurgico, o qual implicaria em novos deslocamentos e mais intensas alteracoes socio-ambientais. Abordam-se, aqui, principalmente, as motivacoes e estrategias do povoado Taim para resistir ao empreendimento do polo, pois suas liderancas assumiram destaque na luta de resistencia por suas acoes e discursos contrarios ao referido empreendimento. Palavras-chave: Povoado do Taim. Grandes projetos de desenvolvimento. Defesa territorial. Conflito socio-ambiental. ABSTRACT This article deals with a situation of socio-environmental conflict between people in the rural zone of the municipality of Sao Luis-MA and large industrial companies, stemming from different forms of perception, control and use of the territory. The conflict began at the end of the 1970's with the installation of large development projects which implied compulsory relocation of people in several villages and alterations in ecosystems and ways of life that had previously existed. At the beginning of 2001 the installation of a large steel refinery was announced, implying new forced relocations in the area as well as intense socio-environmental disruption. Here we deal principally with the motivations and strategies of the people of Taim in resisting this refinery, their leaders have assumed leadership roles in the resistance fight and in the discourse against the Project referred to. Keywords: Taim Village. Large development projects. Territorial defense. Socio-environmental conflict.
Determination of Landfill Gas by Gas Chromatograph-mass Spectrometer Coupled Preconcentration Techniques Method (2012)

Preconcentration techniques combined gas chromatograph-mass spectrometer was evaluated for landfill gas.Using preconcentration techniques,the range of the lowest detection limits for landfill gas were lower than 3.0×10-3 mg/m3,relative standard deviations(n=6) were generally lower than 10%.The method was applied to determine real sample from Xi′an Jiangcungou landfill,satisfactory results were obtained.
CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice (2015)

Acute radiation syndrome results from radiation exposure, such as in accidental nuclear disasters. Safe and effective radioprotectants, mitigators, and treatment drugs must be developed as medical countermeasures against radiation exposure. Here, the authors evaluated CCM-Ami, a novel polyethylene glycol micelle encapsulated with amifostine, for its radioprotective properties after total-body irradiation from a 60Co source. Male C57BL/6 mice (6-8 wk old) were intravenously injected with 45 mg kg(-1) of CCM-Ami 90 min before exposure to 7.2 and 8.5 Gy irradiation at a dose rate of 0.04 Gy min(-1). Both survival benefit and hematopoietic protection were observed after prophylactic CCM-Ami administration when compared with the effects measured in excipient control and amifostine groups. Pharmacokinetic results showed that after the intravenous injection, the plasma concentration of WR-1065, the active form of amifostine, was higher in CCM-Ami-treated mice than in amifostine-treated mice. These findings suggest that CCM-Ami-mediated hematopoietic protection plays a key role in enhancing survival of mice exposed to radiation toxicity and thus indicate that CCM-Ami is a radioprotectant that can be used safely and effectively in nuclear disasters.
Recent advances in nanocellulose for biomedical applications (2014)

ABSTRACT Nanocellulose materials have undergone rapid development in recent years as promising biomedical materials because of their excellent physical and biological properties, in particular their biocompatibility, biodegradability, and low cytotoxicity. Recently, a significant amount of research has been directed toward the fabrication of advanced cellulose nanofibers with different morphologies and functional properties. These nanocellulose fibers are widely applied in medical implants, tissue engineering, drug delivery, wound‐healing, cardiovascular applications, and other medical applications. In this review, we reflect on recent advancements in the design and fabrication of advanced nanocellulose‐based biomaterials (cellulose nanocrystals, bacterial nanocellulose, and cellulose nanofibrils) that are promising for biomedical applications and discuss material requirements for each application, along with the challenges that the materials might face. Finally, we give an overview on future directions of nanocellulose‐based materials in the biomedical field. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41719.
Design and implementation of the POWER5™ microprocessor (2004)

POWER5 offers significantly increased performance over previous POWER designs by incorporating simultaneous multithreading, an enhanced memory subsystem, and extensive RAS and power management support. The 276M transistor processor is implemented in 130nm silicon-on-insulator technology with 8-level of Cu metallization and operates at >1.5 GHz.
Differential localization of HPV16 E6 splice products with E6-associated protein (2005)

High-risk Human Papillomavirus (HPV) is the etiological agent associated with the majority of anogenital cancers. The primary HPV oncogenes, E6 and E7, undergo a complex splicing program resulting in protein products whose purpose is not fully understood. Previous mouse studies have confirmed the existence of a translated product corresponding to the E6*I splice product. In terms of function, the translated E6*I protein has been shown to bind to E6 protein and to E6 associated protein (E6AP). E6*I has an inhibitory effect on E6-mediated p53 degradation in E6 expressing cells. In order to analyze the relationship between E6*I and full-length E6 in relation to localization, we created a series of green fluorescent protein (GFP) fusion products. The localization of these proteins with reference to E6AP in vivo remains unclear. Therefore, we investigated the cellular distribution of different forms of E6 with reference to E6AP. E6 and E6*I proteins, expressed from a wild type E6 gene cassette, were dispersed in the nucleus and the cytoplasm. Whereas, the E6 splice donor mutant (E6MT) was primarily localized to the nucleus. E6*I protein and E6AP were found to co-localize mainly to the cytoplasm, whereas the co-localization of full-length E6 protein and E6AP, if at all, was found mainly at the perinuclear region. These results suggest a functional relationship between the E6*I and full-length E6 protein which correlates with their localization and likely is important in regulation of the E6-E6AP complex.
Management of Hepatocellular Carcinoma: From Prevention to Molecular Targeted Therapy (2010)

Hepatocellular carcinoma is a malignant tumor responsible for approximately 600,000-700,000 deaths worldwide, and is becoming more prevalent not only in South-East Asia and Africa, but also in Western countries; therefore, interest in hepatocellular carcinoma has mounted in recent years in the West, where little or no interest was evident 10-20 years ago.
Interferon-gamma gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation (1992)

Abstract Human interferon-gamma (IFN-gamma) is an important immunomodulatory protein produced predominantly by T cells and large granular lymphocytes (LGLs). Whereas large amounts of data have been accumulated regarding IFN gamma gene expression in these two cell types, little information about IFN gamma expression in other cell types exists. In this study, we have analyzed the production of IFN gamma by the Epstein- Barr virus (EBV)-positive B-cell line, JLP(c), derived from a patient with Burkitt's lymphoma, and another human B-cell line, PA682BM-1, which was derived from an acquired immunodeficiency syndrome patient. Southern blot analysis indicates the presence of an Ig heavy chain gene rearrangement, but no rearrangement of the T-cell receptor beta chain gene or IFN gamma gene in these B-cell lines. Both cell lines were found to express surface IgD and other B-cell surface markers, thus confirming their B-cell lineage. Analysis for surface Ig, cytoplasmic Ig, and secreted Ig indicates that the two cell lines are in relatively early stages of the B-cell differentiation pathway. We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). After activation of the cell lines with IL-2, (-)Indolactam-v, and PMA, increases in cytoplasmic messenger RNAs (mRNAs) of IFN gamma and the IL- 2 receptor chains were also observed. The induction of IFN gamma mRNA and protein by IL-2 was completely blocked by a monoclonal antibody to IL-2 receptor p75 (beta chain), but not by the monoclonal antibody to p55 (alpha chain). Analysis of IFN gamma genomic DNA indicates that the gene is not amplified, but that hypomethylation in the 5′ noncoding region of the IFN gamma gene has occurred in the B-cell line from the Burkitt's lymphoma patient that spontaneously produces IFN gamma. This finding suggests that the methylation state of the promoter region may play an important role in the control of IFN gamma gene expression in B cells.
Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin (2001)

Free radicals have been implicated in the pathogenesis of neonatal asphyxia and its complications. This study measured a product of lipid peroxidation, malondialdehyde, and the nitrite/nitrate levels in the serum of 20 asphyxiated newborns before and after treatment with the antioxidant melatonin given within the first 6 hr of life. Ten asphyxiated newborns received a total of 80 mg of melatonin (8 doses of 10 mg each separated by 2-hr intervals) orally. One blood sample was collected before melatonin administration and two additional blood samples (at 12 and 24 hr) were collected after giving melatonin. A third group of healthy newborn children served as controls. Serum malondialdehyde and nitrite+nitrate concentrations in newborns with asphyxia before treatment were significantly higher than those in infants without asphyxia. In the asphyxiated newborns given melatonin, there were significant reductions in malondialdehyde and nitrite/nitrate levels at both 12 and 24 hr. Three of the 10 asphyxiated children not given melatonin died within 72 hr after birth; none of the 10 asphyxiated newborns given melatonin died. The results indicate that the melatonin may be beneficial in the treatment of newborn infants with asphyxia. The protective actions of melatonin in this study may relate to the antioxidant properties of the indole as well as to the ability of melatonin to increase the efficiency of mitochondrial electron transport.
Mid-infrared time-domain ellipsometry: Application to Nb-doped SrTiO<sub>3</sub> (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Andrea Rubano, Lukas Braun, Martin Wolf, Tobias Kampfrath; Mid-infrared time-domain ellipsometry: Application to Nb-doped SrTiO3. Appl. Phys. Lett. 20 August 2012; 101 (8): 081103. https://doi.org/10.1063/1.4746263 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Using Web annotations for asynchronous collaboration around documents (2000)

Digital web-accessible annotations are a compelling medium for personal comments and shared discussions around documents. Only recently supported by widely used products, "in-context" digital annotation is a relatively unexamined phenomenon. This paper presents a case study of annotations created by members of a large development team using Microsoft Office 2000-approximately 450 people created 9,000 shared annotations on about 1,250 documents over 10 months. We present quantitative data on use, supported by interviews with users, identifying strengths and weaknesses of the existing capabilities and possibilities for improvement.
Effect of Silicon Rate and Host Resistance on Blast, Scald, and Yield of Upland Rice (2000)

Blast-resistant, partially resistant, and susceptible cultivars of rice were planted in soil amended with Si at 0, 500, or 1,000 kg/ha at two locations in eastern Colombia to assess differential responses to leaf blast, neck blast, and leaf scald, and to examine the quantity and quality of grains harvested. Leaf and neck blast on partially resistant and susceptible cultivars were reduced by Si as the rate of Si was increased. Depending on the location, the level of severity of leaf and neck blast on partially resistant cultivars, when fertilized with Si at 500 or 1,000 kg/ha, was lowered to that of resistant cultivars without Si. At both locations, yields were increased by as much as 42%, depending on the cultivar, by Si applied at 1,000 kg/ha. In general, high rates of Si reduced the number of broken grains harvested. Grain discoloration, regardless of cultivar or location, was reduced by as much as 70% at the high rate of Si. The application of Si to complement host resistance to blast and scald appears to be an effective strategy for disease management in rice and provides the added benefit of improving the quantity and quality of rice yields.
Conceptual model of web service reputation (2002)

Current Web services standards enable publishing service descriptions and finding services on a match based on criteria such as method signatures or service category. However, current approaches provide no basis for selecting a good service or for comparing ratings of services. We describe a conceptual model for reputation using which reputation information can be organized and shared and service selection can be facilitated and automated.
Aids and adaptations for the elderly at home: underprovided, underused, and undermaintained (1988)

A random sample of 140 elderly people aged over 75 was selected from the age-sex register of an urban general practice to assess the provision and use of aids and adaptations in their homes. Many of the aids that the elderly had were faulty, including half of the walking aids and 15% of hearing aids, reading spectacles, and dentures, and up to half of the aids were not used. Yet despite this underuse there were many disabled elderly people who required aids for the bath and toilet. When screening of elderly people is carried out in general practice assessment of aids and adaptations should be included to see that they are provided where needed, are used, and are adequately maintained.
Electronic devices and advanced systems technology (2003)

* THz Technology: An Overview (P H Siegel) * Two-Terminal Active Devices for Terahertz Sources (G I Haddad et al.) * Multiplier and Harmonic Generator Technologies for Terahertz Applications (R M Weikle II et al.) * Submicron InP-Based HBTs for Ultra-High Frequency Amplifiers (M Urteaga et al.) * THz Generation by Photomixing in Ultrafast Photoconductors (E R Brown) * Silicon-Germanium Quantum-Cascade Lasers (R W Kelsall & R A Soref) * Plasma Wave Electronics (M S Shur & V Ryzhii) * T-Ray Sensing and Imaging (S P Mickan & X-C Zhang) * Multistatic Reflection Imaging with Terahertz Pulses (T D Dorney et al.)
Compensation of CdZnTe signals using a twin shaping filter technique (2005)

The performance of high Z solid state detectors has been significantly improved over the last decade: one of the most promising materials for X and gamma ray detectors is CdTe/CdZnTe, which has high detection efficiency, no requirement for cooling to cryogenic temperatures, good spectroscopic performances, good time response and imaging capabilities. Unfortunately some important features of semiconductor detectors (pulse height, energy resolution, photopeak efficiency) are affected by the charge collection efficiency: the low mobility of the charge carriers (particularly the holes) and trapping/detrapping phenomena can degrade the CdTe/CdZnTe detectors' performances, depending on the distance between the charge formation position and the collecting electrodes. The deterioration of the spectroscopic performances can be reduced by using either hardware or software techniques. The bi-parametric method herein described is based on a hybrid HW and SW technique that utilizes a twin pulse shaping active filter (one 'slow' and one 'fast') to analyse the same signal. This technique could be particularly suitable for implementation in a readout integrated circuit for multipixel detectors. The experimental results obtained with the application of this biparametric technique with CdZnTe detectors are presented in order to assess the reliability and the efficiency of this compensation method as a function of bias voltage and primary photon energy.
Therapeutic effect of combination of salvia and ligustrazine on bleomycin-induced pulmonary fibrosis (2011)

This work was supported by Sichuan Youth Science and Technology Foundation (No. 2009-04-395 to Xianming Fan) Background: Current agents for the treatment of idiopathic pulmonary fibrosis (IPF) have not been found to improve the prognosis, thus requiring the development of new types of drugs to treat IPF. Aims: This study was designed to investigate the effect of combination of Salvia (one kind of traditional Chinese medicine) and Ligustrazine (one kind of traditional Chinese medicine) on the expression of inflammatory mediators, the mRNA expression of type I and III collagen, and hydroxyproline content in lung tissues in bleomycin (BLM)-induced rat pulmonary fibrosis. Methods: Adult Wistar rats were intratracheally instilled with BLM or normal saline (NS). After intratracheal administration, the animals were intraperitoneally injected with combination of Salvia and Ligustrazine or NS every day. Then they were sacrificed. HE and Masson staining were used to observe alveolitis and fibrosis. Immunohistochemistry analysis was used to examine the expressions of inflammatory mediators in lung tissues, and the mRNA expression of type I and III collagen and hydroxyproline content in lung tissues was also measured. Results: Combination of Salvia and Ligustrazine could alleviate alveolitis and fibrosis; could attenuate the expression of inflammatory mediators in lung tissues; and could also decrease the mRNA expression of type I and III collagen and hydroxyproline content in lung tissue in rat pulmonary fibrosis. Conclusions: Combination of Salvia and Ligustrazine had an anti-fibrosis effect, and it might be considered as a clinically viable option to treat pulmonary fibrosis.