gebhart/patrepeval huggingface dataset:
A design of home subscriber server for IP multimedia service in all-IP UMTS network (2004)

This paper introduces the All IP UMTS based core networks concept for IP Multimedia service. The focus of the study is designing a Home Subscriber Server (HSS) system that satisfies the functional requirement in the defined 3GPP Release 5 standard for the deployment of IP based multimedia services. Initially, it is expected that the basic UMTS core network (CN) will be deployed, with the functional element of the IP multimedia subsystem (IMS) and the signaling protocol among the elements. Then, we propose a competent design scheme for HSS system to provide IP multimedia service. It is divided two parts, a user profile database and a functional scheme of application for easy implementation.
Prostaglandin D2 in allergy: PGD2 has dual receptor systems. (2004)

Allergic inflammations feature an accumulation of T helper 2 (Th2) cells, eosinophils, and basophils into the inflamed sites and are often triggered by antigen-IgE mediated activation of mast cells that secret a variety of mediators. Therefore, the mast cell is known as a conductor cell in allergic inflammations. Prostaglandin (PG) D(2) is the major prostanoid secreted from the activated mast cell and has long been implicated in allergic diseases. The involvement of PGD(2) in allergic inflammation has been corroborated by several studies. Two PGD(2) receptors are known as the DP receptor and CRTH2. CRTH2 differs from DP in its signal pathways: CRTH2 is coupled with Gi-type G protein and DP is coupled with Gs-type G protein. It was reported that DP-deficient mice subjected to ovalbumin-induced asthma model systems showed suppressed allergic reactions. Functions of CRTH2 in vivo have not been clear, but CRTH2 mediates PGD(2)-dependent cell migration and the activation of Th2 cells, eosinophils, and basophils. Therefore, the CRTH2 signal seems to promote allergic disease. The findings from these in vivo and vitro studies suggest that PGD(2) secreted from activated mast cells may be involved in the formation and/or maintenance of allergic inflammations through its dual receptor systems.
Corrosion of AB{sub 5} metal hydride electrodes (1997)

Metal hydride electrodes are an attractive substitute for the cadmium electrode in Cd/Ni batteries because of their relatively benign environmental impact and higher energy density. However, even though MH{sub x}/Ni batteries are currently competitive in certain applications, their full potential as cheap, reliable, energy storage devices is not yet realized: a severe penalty has been incurred in storage capacity and materials costs in order to inhibit corrosion and attain acceptable electrode cycle life. Currently there are two types of alloys which are useful as metal hydride electrodes, the AB{sub 5} and the AB{sub 2} classes of intermetallic compounds. Commercial AB{sub 5} electrodes use mischmetal, a low cost combination of rare earth elements. The B{sub 5} component remains primarily Ni but is substituted in part with Co, Mn, Al etc. The partial substitution of Ni increases thermodynamic stability of the hydride phase and corrosion resistance. Such an alloy is commonly written as MmB{sub 5} where Mm represents the mischmetal component; the B{sub 5} composition in commercial batteries is variable but electrodes consisting of MmNi{sub 3.55}Co{sub .75}Mn{sub .4}Al{sub .3} have good storage capacity and cycle life and most AB{sub 5} battery electrodes have a similar composition. The authors have been concerned with the function that individual components play in such an alloy with respect to lattice expansion, hydride stability, and surface passivation. Thus they have focused on the properties of a similar alloy, A(NiCoMnAl){sub 5} where A is La or La{sub 1{minus}x}Ce{sub x}. Some of their results noted here have previously appeared in separate publications; the purpose of this paper is to combine them with new data to give a more coherent and complete whole.
Clozapine for Treatment-Refractory Schizophrenia, Schizoaffective Disorder, and Psychotic Bipolar Disorder (2000)

Clozapine appears to be effective and relatively well tolerated in acute and long-term treatment of patients with psychotic bipolar disorder or schizoaffective disorder who have not responded to conventional pharmacotherapies.
CLASSIFIED Ads (2003)

The Howard-Tilton Memorial Library at Tulane University is seeking an energetic, creative, and collaborative individual
Frequent subgraph mining algorithms on weighted graphs (2023)

This thesis describes research work undertaken in the field of graph-based knowledge discovery (or graph mining). The objective of the research is to investigate the benefits that the concept of weighted frequent subgraph mining can offer in the context of the graph model based classification. Weighted subgraphs are graphs where some of the vertexes/edges are considered to be more significant than others. How to discover frequent sub-structures with different strengths is the main issue to be resolved in this thesis. The main approach to addressing this issue is to integrate weight constraints into the frequent subgraph mining process. It is suggested that the utilization of weighted frequent subgraph mining generates more discriminate and significant subgraphs, which will have application in, for example, the classification and clustering of graph data.
Design And Implementation Of A Wifi Based Home Automation System (2012)

This paper presents a design and prototype implementation of new home automation system that uses WiFi technology as a network infrastructure connecting its parts. The proposed system consists of two main components; the first part is the server (web server), which presents system core that manages, controls, and monitors users- home. Users and system administrator can locally (LAN) or remotely (internet) manage and control system code. Second part is hardware interface module, which provides appropriate interface to sensors and actuator of home automation system. Unlike most of available home automation system in the market the proposed system is scalable that one server can manage many hardware interface modules as long as it exists on WiFi network coverage. System supports a wide range of home automation devices like power management components, and security components. The proposed system is better from the scalability and flexibility point of view than the commercially available home automation systems.
A New Highly Selective H<sub>2</sub> Sensor Based on TiO<sub>2</sub>/PtO−Pt Dual-Layer Films (2002)

A new highly selective hydrogen sensor based on TiO2/PtO−Pt dual-layer films has been prepared. At 180−200 °C, the prepared nanostructured sensor exhibits an excellent selectivity and good sensitivity to H2 in air but is immune to many other kinds of reductive gases such as CO, NH3, and CH4. The sensor can give a faithful response to 1% H2 in air, while the limitation for detecting H2 in nitrogen is less than 1000 ppm. Influences of operation temperature and humidity on the sensing performance of the sensor were also investigated. The mechanism of the present sensor was attributed to the partial reduction of Ti4+ to Ti3+ by hydrogen catalyzed by a thin film of surface-oxidized Pt nanoparticles.
A High Quality/Low Computational Cost Technique for Block Matching Motion Estimation (2005)

Motion estimation is the most critical process in video coding systems. First of all, it has a definitive impact on the rate-distortion performance given by the video encoder. Secondly, it is the most computationally intensive process within the encoding loop. For these reasons, the design of high-performance low-cost motion estimators is a crucial task in the video compression field. An adaptive cost block matching (ACBM) motion estimation technique is presented in this paper, featuring an excellent tradeoff between the quality of the reconstructed video sequences and the computational effort. Simulation results demonstrate that the ACBM algorithm achieves a slightly better rate-distortion performance than the one given by the well-known full search algorithm block matching algorithm with reductions of up to 95% in the computational load.
Low-Bandwidth Topology Maintenance for Robustness in Structured Overlay Networks (2005)

Structured peer-to-peer systems have emerged as infrastructures for resource sharing in large-scale, distributed, and dynamic environments. One challenge in these systems is to efficiently maintain routing information in the presence of nodes joining, leaving, and failing. Many systems use costly periodic stabilization protocols to ensure that the routing information is up-to-date. In this paper, we present a novel technique called correction-on-change, which identifies and notifies all nodes that have outdated routing information as a result of a node joining, leaving, or failing. Effective failure handling is simplified as the detection of a failure triggers a correction-on-change which updates all the nodes that have a pointer to the failed node. The resulting system has increased robustness as nodes with stale routing information are immediately updated. We proof the correctness of the algorithms and evaluate its performance by means of simulation. Experimental results show that for the same amount of maintenance bandwidth correction-on-change makes the system by far more robust when compared to periodic stabilization. Moreover, compared to adaptive stabilization which adjusts its frequency to the dynamism in the system, correction-on-change gives the same performance but with considerably less maintenance bandwidth. As correction-on-change immediately updates incorrect routing entries the average lookup length is maintained close to the theoretical average in the presence of high dynamism. We show how the technique can be applied to our DKS system as well as the Chord system.
Effects of Long-Term Administration of 9-<i>cis</i>-Retinyl Acetate on Visual Function in Mice (2009)

Deteriorating photoreceptor function documented in mice at 10 and 14 versus 4 months of age was improved significantly by long-term, monthly administration of 9-cis-R-Ac. These findings suggest a potential therapeutic approach to prevent age-related retinal dysfunction.
Increased Serum Interleukin-9 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Pathogenic Role or Just an Epiphenomenon? (2015)

The purpose of this paper was to evaluate the levels of IL-9 in patients with SLE and RA compared with controls and the association of IL-9 levels with clinical and laboratory parameters. IL-9 levels were assessed in 117 SLE patients, 67 RA patients, and 24 healthy controls by ELISA. Clinical and laboratory parameters were recorded. The IL-9 serum levels were significantly higher in RA patients (4,77 ± 3,618 pg/mL) and in SLE patients (12,26 ± 25,235 pg/mL) than in healthy individuals (1,22 ± 0,706 pg/mL) (p < 0,001). In SLE patients, there were no statistically significant associations or correlations between the levels of IL-9 and SLEDAI or other clinical and laboratorial parameters, with the exception of disease time, which showed a statistically significant negative correlation with IL-9 levels (r = -0,1948; p = 0,0378). In RA patients, no association or statistically significant correlation was observed with disease duration, DAS28, HAQ, rheumatoid factor positivity, or erosions on radiography. These data demonstrated increased serum levels of IL-9 in SLE and RA patients, but further studies are needed to clarify the precise role of this cytokine and its potential use as therapeutic target.
ChemInform Abstract: S,O‐ versus S,N‐Chelation in the Reactions of the cis‐Diamminediaquoplatinum(II) Cation with Methionine and S‐Methylcysteine. (1988)

Abstract The title reactions are followed by 1 H, 13 C, 15 N, and 195 Pt NMR.
Serum and mucosal antibody responses to pneumococcal protein antigens in children:relationships with carriage status (2005)

Streptococcus pneumoniae causes significant morbidity and mortality especially in children. Some pneumococcal protein antigens can protect mice against infection. Little information is available concerning the nature of naturally acquired protective immunity to pneumococci in humans induced by these antigens. This study investigates the relationships between systemic and local antibody production and carriage in children. Children undergoing adenoidectomy (n=112, ages 2-12 years) were studied. Nasopharyngeal swabs were collected for pneumococcal culture. Serum and saliva were assayed for antibodies to several pneumococcal proteins: choline binding protein A (CbpA), pneumolysin (Ply), pneumococcal surface adhesin A (PsaA) and pneumococcal surface protein A (PspA). Adenoidal mononuclear cells (MNC) were cultured with pneumococcal culture supernatants or recombinant proteins. Cell culture supernatants were analyzed for antigen-specific antibodies. Carriage rates fell with age and serum levels of anti-CbpA, Ply and PspA rose. Anti-CbpA and -Ply serum and salivary IgG antibody levels were higher in children who were culture negative than those who were colonized. Antigen stimulation increased respective antigen-specific IgG production by adenoidal MNC and these responses were greater in those who were colonized than in culture-negative children. Antibodies to CbpA and Ply may protect children aged 2 years and older against pneumococcal colonization. Adenoids may be important local induction and effector sites for both mucosal and systemic antibody production to pneumococcal proteins in children.
DewarpNet: Single-Image Document Unwarping With Stacked 3D and 2D Regression Networks (2019)

Capturing document images with hand-held devices in unstructured environments is a common practice nowadays. However, "casual" photos of documents are usually unsuitable for automatic information extraction, mainly due to physical distortion of the document paper, as well as various camera positions and illumination conditions. In this work, we propose DewarpNet, a deep-learning approach for document image unwarping from a single image. Our insight is that the 3D geometry of the document not only determines the warping of its texture but also causes the illumination effects. Therefore, our novelty resides on the explicit modeling of 3D shape for document paper in an end-to-end pipeline. Also, we contribute the largest and most comprehensive dataset for document image unwarping to date - Doc3D. This dataset features multiple ground-truth annotations, including 3D shape, surface normals, UV map, albedo image, etc. Training with Doc3D, we demonstrate state-of-the-art performance for DewarpNet with extensive qualitative and quantitative evaluations. Our network also significantly improves OCR performance on captured document images, decreasing character error rate by 42% on average. Both the code and the dataset are released.
Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer’s disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities (2017)

The purpose of our study was to develop a therapeutic target that can reduce Aβ and Drp1 levels, and also can inhibit abnormal interactions between Aβ and Drp1 in AD neurons. To achieve this objective, we designed various compounds and their 3-dimensional molecular structures were introduced into Aβ and Drp1 complex and identified their inhibitory properties against Aβ-Drp1 interaction. Among all, DDQ was selected for further investigation because of 1) its best docking score and 2) its binding capability at interacting sites of Drp1 and Aβ complex. We synthesized DDQ using retro-synthesis and analyzed its structure spectrally. Using biochemical, molecular biology, immunostaining and transmission electron microscopy (TEM) methods, we studied DDQ's beneficial effects in AD neurons. We measured the levels of Aβ and Drp1, Aβ and Drp1 interaction, mRNA and protein levels of mitochondrial dynamics, biogenesis and synaptic genes, mitochondrial function and cell viability and mitochondrial number in DDQ-treated and untreated AD neurons. Our qRT-PCR and immunoblotting analysis revealed that reduced levels of mitochondrial fission and increased fusion, biogenesis and synaptic genes in DDQ-treated AD neurons. Our immunoblotting and immunostaining analyses revealed that Aβ and Drp1 levels were reduced in DDQ-treated AD neurons. Interaction between Aβ and Drp1 is reduced in DDQ-treated AD neurons. Aβ42 levels were significantly reduced in DDQ-treated mutant APPSwe/Ind cells. Mitochondrial number is significantly reduced and mitochondrial length is significantly increased. Mitochondrial function and cell viability were maintained in AD neurons treated with DDQ. These observations indicate that DDQ reduces excessive mitochondrial fragmentation, enhances fusion, biogenesis and synaptic activity and reduces Aβ42 levels and protects AD neurons against Aβ-induced mitochondrial and synaptic toxicities.
Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules. (1995)

The synthesis of nitric oxide by proximal tubule-inducible nitric oxide synthase requires tetrahydrobiopterin as a cofactor. To determine whether tetrahydrobiopterin synthesis is required for nitric oxide production, nitrite release by mouse proximal tubule cells treated with 2,4-diamino-6-hydroxypyrimidine, an inhibitor of the rate-limiting enzyme in the de novo synthesis of tetrahydrobiopterin from guanosine triphosphate, guanosine triphosphate cyclohydrolase I, was measured. Treatment with lipopolysaccharide (0.1 micrograms/mL) and interferon-gamma (100 U/mL) for 12 h increased nitrite production from 2.7 +/- 0.2 to 25.4 +/- 1.3 nmol/mg of protein (P < 0.001; N = 9). 2,4-Diamino-6-hydroxypyrimidine (6 mM) reduced lipopolysaccharide/interferon-gamma-induced nitrite production by 53.1 +/- 3.4%. Sepiapterin, a substrate for tetrahydrobiopterin synthesis via the dihydrofolate reductase-dependent pterin salvage pathway, prevented the inhibition by 2,4-diamino-6-hydroxypyrimidine, an effect that was blocked by methotrexate. In conclusion, guanosine triphosphate cyclohydrolase I activity is required for cytokine-induced nitric oxide production by proximal tubular epithelium. The inhibition of guanosine triphosphate cyclohydrolase I could prove useful in the treatment of nitric oxide-mediated renal disorders.
KGBassembler: a karyotype-based genome assembler for <i>Brassicaceae</i> species (2012)

xwang1@cals.arizona.edu.
Circulatory regulation during exercise in different ambient temperatures (1979)

Three relatively fit subjects performed duplicate 20- to 25-min cycle ergometer exercise bouts at moderate and heavy intensities (40% and 70% Vo2 max) in ambient temperatures of 20, 26, and 36 degrees C. They approached a steady state in internal body temperature (Tes) in all but the heavy exercise in the heat, where Tes rose consistently, averaging 38.84 degrees C at the termination of exercise. Cardiac output (Q), estimated by a rebreathing technique, was proportional to Vo2 and independent of the body temperatures, except during the lower exercise intensity in the heart, where Q averaged 1.31 . min -1 higher throughout. In any environment, forearm blood flow was linearly related to Tes above the Tes threshold for vasodilation, but during heavy exercise in the heat this relationship was severely attenuated above a Tes around 38.0 degrees C, when forearm blood flow exceeded 15 ml.min -1 .100 ml -1. Plasma volume decreases during exercise were primarily a function of the intensity of exercise. During heavy exercise in the heat the relative vasconstriction contributes to the maintenance of an adequate stroke volume preventing a fall in Q. In this case, circulatory regulation has precedence over temperature regulation.
Influence of pore‐pressure on the event‐size distribution of induced earthquakes (2012)

During an Enhanced Geothermal System (EGS) experiment, fluid is injected at high pressure into crystalline rock, to enhance its permeability and thus create a reservoir from which geothermal heat can be extracted. The fracturing of the basement caused by these high pore‐pressures is associated with microseismicity. However, the relationship between the magnitudes of these induced seismic events and the applied fluid injection rates, and thus pore‐pressure, is unknown. Here we show how pore‐pressure can be linked to the seismic frequency–magnitude distribution, described by its slope, the b ‐value. We evaluate the dataset of an EGS in Basel, Switzerland and compare the observed event‐size distribution with the outcome of a minimalistic model of pore‐pressure evolution that relates event‐sizes to the differential stress σ D . We observe that the decrease of b ‐values with increasing distance of the injection point is likely caused by a decrease in pore‐pressure. This leads to an increase of the probability of a large magnitude event with distance and time.
Limiting Damage during Infection: Lessons from Infection Tolerance for Novel Therapeutics (2014)

The distinction between pathogen elimination and damage limitation during infection is beginning to change perspectives on infectious disease control, and has recently led to the development of novel therapies that focus on reducing the illness caused by pathogens (‘‘damage limitation’’)rather than reducing pathogen burdens directly (‘‘pathogen elimination’’). While beneficial at the individual host level, the population consequences of these interventions remain unclear. To address this issue,we present a simple conceptual framework for damage limitation during infection that distinguishes between therapies that are either host-centric (pro-tolerance) or pathogen-centric (anti-virulence). We then draw on recent developments from the evolutionary ecology of disease tolerance to highlight some potential epidemiological and evolutionary responses of pathogens to medical interventions that target the symptoms of infection. Just as pathogens are known to evolve in response to antimicrobial and vaccination therapies, we caution that claims of ‘‘evolution-proof’’ anti-virulence interventions may be premature, and further, that in infections where virulence and transmission are linked, reducing illness without reducing pathogen burden could have non-trivial epidemiological and evolutionary consequences that require careful examination.
Screening for Antioxidant Activity in Edible Plant Products:  Comparison of Low-Density Lipoprotein Oxidation Assay, DPPH Radical Scavenging Assay, and Folin−Ciocalteu Assay (2004)

Oxidation of low-density lipoprotein (LDL) has been implicated in atherogenesis. Antioxidants that prevent LDL from oxidizing may reduce atherosclerosis. This study investigated LDL antioxidant activity in edible plant products for development of dietary supplementation to prevent atherosclerosis. Fifty-two kinds of edible plants were extracted using 70% aqueous ethanol solution, and the antioxidant activity of the extracts, which inhibit human LDL oxidation induced by copper ion, was determined on the basis of the oxidation lag time and represented as epigallocatechin 3-gallate equivalent. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and total phenolic content were also measured for comparisons with antioxidant activity in LDL. Plant products showing the greatest activity in LDL oxidation assay were akamegashiwa (Mallotus japonicus) leaf, Japanese privet (Ligustrum japonicum) leaf, green tea [Camellia sinensis (L.) O. Kuntze], and astringent persimmon (Diospyros kaki). The present study revealed high levels of LDL antioxidant activity in plant products for which such activity levels are underestimated in the DPPH radical scavenging assay and Folin-Ciocalteu assay.
Optimal device design of FinFETs on a bulk substrate (2011)

An optimal device design methodology for bulk FinFETs is proposed. A feasible yet simple process technique is shown to achieve good performance while maintaining low leakage current with thin isolation oxide and doped substrate.