gebhart/patrepeval huggingface dataset:
Deep Interest Evolution Network for Click-Through Rate Prediction (2018)

Click-through rate~(CTR) prediction, whose goal is to estimate the probability of the user clicks, has become one of the core tasks in advertising systems. For CTR prediction model, it is necessary to capture the latent user interest behind the user behavior data. Besides, considering the changing of the external environment and the internal cognition, user interest evolves over time dynamically. There are several CTR prediction methods for interest modeling, while most of them regard the representation of behavior as the interest directly, and lack specially modeling for latent interest behind the concrete behavior. Moreover, few work consider the changing trend of interest. In this paper, we propose a novel model, named Deep Interest Evolution Network~(DIEN), for CTR prediction. Specifically, we design interest extractor layer to capture temporal interests from history behavior sequence. At this layer, we introduce an auxiliary loss to supervise interest extracting at each step. As user interests are diverse, especially in the e-commerce system, we propose interest evolving layer to capture interest evolving process that is relative to the target item. At interest evolving layer, attention mechanism is embedded into the sequential structure novelly, and the effects of relative interests are strengthened during interest evolution. In the experiments on both public and industrial datasets, DIEN significantly outperforms the state-of-the-art solutions. Notably, DIEN has been deployed in the display advertisement system of Taobao, and obtained 20.7\% improvement on CTR.
<i>Listeria monocytogenes</i>σ<sup>B</sup>Contributes to Invasion of Human Intestinal Epithelial Cells (2004)

The role of sigma(B) in Listeria monocytogenes infection of human intestinal epithelial cells was investigated. Invasion defects associated with loss of sigma(B) paralleled those of a DeltainlA strain independently of the sigma(B)-dependent P2(prfA) promoter. Concomitantly, amounts of inlA transcript and InlA protein were significantly decreased in the DeltasigB strain.
Network Architecture Design for Back-End Storage Networks (1980)

To realize the full potential of computer networking, design of a back-end storage network architecture should follow the general-purpose approach of an evolving network operating system.
Skateboards, Bicycles, and Three-dimensional Biped Walking Machines: Velocity-dependent Stability by Means of Lean-to-yaw Coupling (2005)

One of the great challenges in the development of passive dynamic walking robots (useful for an understanding of human gait and for future applications in entertainment and the like) is the stabilization of three-dimensional motions. This is a difficult problem due to the inherent interaction between fore-aft motions and sideways motions. In this paper we propose a simple solution. Conceptually, one can avert a sideways fall by steering in that direction, similar to skateboards and bicycles. We propose to implement this concept for walking robots by the introduction of an ankle joint that kinematically couples lean to yaw. The ankle joint has an unusual orientation; its axis points forward and downward, without any left-right component. The effect of the ankle joint is investigated in a simple three-dimensional model with three internal degrees of freedom: one at the hip and two at the ankles. It has cylindric feet and an actuator at the hip joint, which quickly moves the swing leg to a preset forward position. The simulations show that it is easy to find a stable configuration, and that the resultant walking motion is highly robust to disturbances. Similar to skateboards and bicycles, there exists a critical velocity (as a function of the parameters) above which stable walking motions occur. The critical velocity can be lower for a more vertical ankle axis orientation. As an additional benefit, the ankle joint allows a straightforward implementation for steering; a simple sideways offset of the mass distribution will cause the model to gently steer in that direction. The results show great potential for the construction of a real-world prototype with the proposed ankle joint.
Robust ultrasonic reverberation clutter suppression using Multi-Apodization with Cross-correlation (2014)

Dual Apodization with Cross-correlation (DAX) is a novel beamforming technique that utilizes a pair of complementary receive apodizations for clutter suppression in ultrasound imaging. The effectiveness of DAX in-vivo is often reduced because of the strong reverberation clutter signals caused by near-field structures. In this work, we propose a modified version of DAX, known as Multi-Apodization with Cross-correlation (MAX), which suppresses reverberation clutter in a highly robust manner by utilizing multiple pairs of receive apodizations followed by normalized cross-correlation. Our simulation, experimental and initial clinical results show that MAX achieves a large improvement over DAX in terms of image contrast and shows great potential for more accurate diagnosis in clinics.
Polymorphic Cocrystals of Nutraceutical Compound <i>p</i>-Coumaric Acid with Nicotinamide: Characterization, Relative Solid-State Stability, and Conversion to Alternate Stoichiometries (2014)

Nutraceutical compound p-coumaric acid, a phytochemical that possesses antioxidant and anti-inflammatory properties, was cocrystallized with nicotinamide, a member of the vitamin B complex, resulting in the discovery of three polymorphic 1:1 cocrystals. Slurries of two forms of the 1:1 cocrystal in water induced conversion to a 2:1 (p-coumaric acid-nicotinamide) cocrystal. In situ monitoring of this conversion at limited conditions by dispersive Raman spectroscopy illustrates rapid incomplete transformation. Additionally, a variety of conditions were evaluated to reach complete conversion. All four cocrystals were characterized by X-ray powder diffraction, thermal analyses, and spectroscopic techniques. In addition, single crystal structures for two of the 1:1 polymorphic cocrystals are presented. Further, competitive slurries, isothermal solution calorimetry, and differential scanning calorimetry analyses at a variety of heating rates were employed to explore the thermodynamic relationships among the three polymorphs.
Fighting Phishing the Information-Centric Way (2012)

Recent research efforts have highlighted the role of information as key target future network architectures. These so-called information centric networks base their operation on the information itself, rather than on other aspects or entities of the architecture, such as location, host, or user identity. In this paper we apply this approach at the application layer of the current Internet in order to mitigate a significant threat: phishing attacks. We designed a mechanism capable of detecting phishing Web pages based on the information that the user perceives while browsing, i.e, the mechanism detects attacks based on the browser's graphical output, rather than on the code of the Web page. We implemented this mechanism in the form of a browser extension and we evaluated it using real data from a publicly available database of phishing URLs. Our extension, which is not affected by the location, popularity, or implementation of a Web page, detected 81% of the phishing attempts.
Kinetics, salivary excretion of amphetamine isomers, and effect of urinary pH (1978)

Amphetamine was administered to healthy subjects as the racemic mixture and as (+)‐and (−)‐isomers under conditions of urine acidification and alkalinization. Plasma and saliva concentration of each isomer was measured and the kinetics of the individual isomers were determined. (+)‐amphetamine was eliminated more rapidly than the (−)‐isomer. The difference in half‐life between isomers was maximal under basic urinary pH conditions. Saliva amphetamine levels were higher than plasma levels and in the postabsorptive phase were predictably proportional to plasma drug levels.
New concept readied for deepwater production (1982)

A new submerged tower design for deepwater applications offshore eliminates most of the problems associated with the air-water interface while permitting use of conventional shallow-water techniques and equipment. What amounts to a submerged tension-leg platform, the new design, named the Alga tower, now under development for a four-well field in the Mediterranean Sea, locates Christmas trees and other well equipment below ocean storms but within conventional diver capability. All production-handling equipment is supported by a surface vessel. A discussion is presented of the design philosophy; components; structural tower; well equipment; production handling; and, safety.
Suppression of the intensity noise of a laser-diode-pumped single-frequency ring Nd:YVO_4–KTP green laser by optoelectronic feedback (2001)

We investigate the different characteristics of the intensity noise of a laser-diode-pumped single-frequency ring Nd:YVO (4) laser and a Nd:YVO (4)-KTP green laser. By use of an optoelectronic feedback circuit connected directly to the pump current of the laser diode, the low-frequency intensity noise of the intracavity frequency doubler was suppressed to some extent.
Selection of the 5′‐proximal translation initiation site is influenced by mRNA and eIF‐2 concentrations (1990)

A cDNA clone of the influenza virus NS (non-structural protein) gene in a vector carrying a bacteriophage T7 RNA polymerase promoter was manipulated so as to reiterate the initiation site to give two in-frame AUG codons 57 nucleotide residues apart. Each initiation site was in either a preferred context (...AUAAUGG...) or a less favourable context (...UUUAUGG...) and the four possible permutations were constructed. When capped mRNA transcripts of these clones were translated in the rabbit reticulocyte lysate system, products from initiation at both AUG codons were observed. At low RNA concentrations the frequency of initiation at the 5'-proximal AUG codon rather than the second was higher when the first AUG codon was in the preferred context, in qualitative agreement with the scanning ribosome model. However, a completely unexpected finding was that the ratio of initiation at the first AUG codon to initiation at the second decreased with increasing mRNA concentration, irrespective of the particular context involved. Several lines of evidence indicated that the increased frequency of initiation at the second AUG codon was not due solely to the lower density of ribosome loading per mRNA at high RNA concentrations, and may therefore be the result of high RNA concentrations out-titring the capacity of endogenous reticulocyte factors responsible for preferential initiation at the 5'-proximal AUG codon. The effect of supplementing the system with purified initiation factors was examined. Only eIF-2 was capable of decreasing the frequency of initiation at the second AUG codon and promoting use of the first AUG at high mRNA concentrations; eIF-3, 4A, 4B, 4C + 4D, 4F and 5 were inactive.
Trialkylsilyl triflates. 5. A stereoselective aldol-type condensation of enol silyl ethers and acetals catalyzed by trimethylsilyl trifluoromethanesulfonate (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrialkylsilyl triflates. 5. A stereoselective aldol-type condensation of enol silyl ethers and acetals catalyzed by trimethylsilyl trifluoromethanesulfonateS. Murata, M. Suzuki, and R. NoyoriCite this: J. Am. Chem. Soc. 1980, 102, 9, 3248–3249Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://doi.org/10.1021/ja00529a062RIGHTS & PERMISSIONSArticle Views1631Altmetric-Citations249LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (269 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Phase 1 and dose-finding study of patritumab (U3-1287), a human monoclonal antibody targeting HER3, in Japanese patients with advanced solid tumors (2014)

Patritumab was well tolerated up to 18 mg/kg without DLTs in Japanese patients with advanced solid tumors. Soluble HER3 increased in all patients.
Why and how do the shapes of surface‐enhanced Raman scattering spectra change? Recent progress from mechanistic studies (2016)

The present review is focused on understanding the enhancement mechanisms in surface‐enhanced Raman scattering (SERS) from the point of view of the various spectral changes, which have brought considerable confusion in this research field and have obstructed practical SERS applications. The electromagnetic mechanism provides us with the quantitative explanation of unexpected SERS spectral changes, such as larger Raman intensities for anti‐Stokes peaks than for Stokes peaks and overtone peak intensities comparable with fundamental ones. Other mechanisms classified as chemical effects, i.e. the resonance Raman and the charge transfer mechanisms, are also introduced to explain the spectral changes in SERS. These mechanisms may explain the emergence of non‐totally symmetric vibrational modes in SERS spectra, which is usually forbidden in Raman spectra. Copyright © 2016 John Wiley & Sons, Ltd.
Improving Input Accuracy on Smartphones for Persons who are Affected by Tremor using Motion Sensors (2018)

Having a hand tremor often complicates interactions with touchscreens on mobile devices. Due to the uncontrollable oscillations of both hands, hitting targets can be hard, and interaction can be slow. Correcting input needs additional time and mental effort. We propose a method for automatically correcting such inputs based on motion data, gathered both with the devices' sensors and a small wearable sensor on the finger used for tapping. The development was informed by interviews with persons with tremor. Two empirical studies showed that our method, involving both smartphone and finger motion sensors without changing the user interface, allows users with tremor to select objects with up to 40 % fewer misses.
Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke (2013)

The EMT process is present in bronchial epithelial cells of the small bronchi of smokers and patients with COPD and is activated by cigarette smoke in vitro.
The Heyns Rearrangement Revisited: An Exceptionally Simple Two-Step Chemical Synthesis ofD-Lactosamine from Lactulose (1999)

Disaccharides containing D-glucosamine at the reducing end can be conveniently synthesized in good yields from O-glycosylated D-fructoses by the title reaction [Eq. (a)]. With all the disaccharides investigated, the method proceeded-presumably because of the pronounced destabilizing interactions of the glycosyl residue at O-4 with the other polar groups-considerably more efficiently than with unsubstituted D-fructose, whose reaction with ammonia to give D-glucosamine was described by Heyns and Koch in the 1950s.
Deformable block-based motion estimation in omnidirectional image sequences (2017)

This paper presents an extension of block-based motion estimation for omnidirectional videos, based on a translational object motion model that accounts for the spherical geometry of the imaging system. We use this model to design a new algorithm to perform block matching in sequences of panoramic frames that are the result of the equirectangular projection. Experimental results demonstrate that significant gains can be achieved with respect to the classical exhaustive block matching algorithm in terms of accuracy of motion prediction. In particular, average quality improvements up to approximately 6 dB in terms of Peak Signal to Noise Ratio (PSNR), 0.043 in terms of Structural SIMilarity index (SSIM), and 2 dB in terms of spherical PSNR, can be achieved on the predicted frames.
Overview of 3GPP Release 14 Enhanced NB-IoT (2017)

In 3GPP LTE Release 13, Narrowband Internet of Things (NB-IoT) was standardized for providing wide-area connectivity for massive machine-type communications for IoT. In LTE Release 14, NB-IoT was further developed to deliver enhanced user experience in selected areas through the addition of features such as increased positioning accuracy, increased peak data rates, the introduction of a lower device power class, improved non-anchor carrier operation, multicast, and authorization of coverage enhancements. In this article, we provide an overview of these features introduced for NB-IoT in LTE Release 14. An analysis is given on the applicability of these features and their benefits to enhance the NB-IoT radio access technology.
Influence of Nicotine and Cotinine on the Expression of Plasminogen Activator Activity in Bovine Aortic Endothelial Cells (1989)

The effects of nicotine and its major metabolite, cotinine, were evaluated on the secretion of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) in cultured bovine aortic endothelial cells. Both compounds increased PA secretion, determined by 125I fibrin plate assay, in a time- and dose-dependent manner. Maximum effects after 24 hr incubation were observed for nicotine at 10(-8) M and for cotinine at 10(-7) M, which corresponded to about 2.6-fold increases over control for both compounds. The pharmacological PA stimulation required both RNA and protein syntheses, as evidenced by inhibition by actinomycin D and cycloheximide. Both control and treated cells produced multiple forms of PA, as evaluated by SDS-PAGE zymography, and a single form of PAI, as evidenced by reverse fibrin autography. Although activities of all species of PA were enhanced by nicotine and cotinine, these compounds had no significant effects on the release of PAI. These results thus suggest that nicotine and cotinine may have fibrinolytic activity in vivo.
Inhibiting Amyloid Precursor Protein C-terminal Cleavage Promotes an Interaction with Presenilin 1 (2000)

Presenilin 1 (PS1) plays a pivotal role in the production of the amyloid-beta protein, which is central to the pathogenesis of Alzheimer's disease. It has been demonstrated that PS1 regulates the gamma-secretase proteolysis of the amyloid precursor protein (APP) C-terminal fragment (APP-C100), which is the final step in amyloid-beta protein production. The mechanism and detailed pathway of this PS1 activity has yet to be fully resolved, but it may be due to a presenilin-controlled trafficking of the APP fragment or possibly an inherent PS1 proteolytic activity. We have investigated the possibility of a direct interaction of PS1 and the APP-C100 within the high molecular mass presenilin complex. However, the APP-C100 is rapidly degraded, and if it forms, then any PS1.APP complex is likely to be very transitory. To circumvent this problem, we have utilized the protease inhibitor N-acetyl-leucyl-norleucinal (LLnL) and the lysosomotropic agent NH(4)Cl, which inhibits the turnover of the APP-C100. Under these conditions, levels of the fragment increased appreciably, and as shown by glycerol gradient analysis, the APP-C100 shifted to a higher molecular mass complex that overlapped with PS1. Immunoprecipitation studies demonstrated that a significant population of the APP-C100 co-precipitated with PS1. These findings suggest that PS1 may mediate the shuttling of APP fragments and/or facilitate their presentation for gamma-secretase cleavage through a direct interaction.
Cone-based electrical resistivity tomography (2006)

Abstract Determining the 3D spatial distribution of subsurface properties is a challenging, but critical, part of managing the cleanup of contaminated sites. We have developed a minimally invasive technology that can provide information about the 3D distribution of electrical conductivity. The technique, cone-based electrical resistivity tomography (C-bert), integrates resistivity tomography with cone-penetration testing. Permanent current electrodes are emplaced in the subsurface and used to inject current into the subsurface region of interest. The resultant potential fields are measured using a surface reference electrode and an electrode mounted on a cone penetrometer. The standard suite of cone penetration measurements, including high-resolution resistivity logs, are also obtained and are an integral part of the C-bert method. C-bert data are inverted using an inexact Gauss-Newton algorithm to produce a 3D electrical conductivity map. A majorchallenge with the inversion is the large local perturbation around the measurement location, due to the highly conductive cone. As the cone is small with respect to the total model space, explicit modeling of the cone is cost prohibitive. We have developed a rapid method for solving the forward model which uses iteratively determined boundary conditions (IDBC). This allows us to generate a computationally feasible, preinversion correction for the cone perturbation. We assessed C-bert by performing a field test to image the conductivity structure of the Kidd 2 site near Vancouver, British Columbia. A total of nine permanent current electrodes were emplaced and five C-bert data sets were obtained, resulting in 6516 data points. These data were inverted to obtain a 3D conductivity image of the subsurface. Furthermore, we demonstrated, using a synthetic experiment, that C-bert can yield high quality electrical conductivity images in challenging field situations. We conclude that C-bert is a promising new imaging technique.
Purification and identification of angiotensin I-converting enzyme inhibitors from the red alga Porphyra yezoensis. (1998)

The potent part of the angiotensin I-converting enzyme (ACE) inhibitory activity from Porphyra yezoensis hydrolysate was fractionated by using ion-exchange and gel-filtration techniques. Oral administration of the most potent inhibitory fraction (SP-I fraction, 200 mg/kg) to spontaneously hypertensive rats (SHR) showed a hypotensive effect. Using octadecylsilano column chromatography, the SP-I fraction was further separated into several peptides with potent inhibitory activities. The amino acid sequences of ACE inhibitory peptides derived from Porphyra yezoensis were Ile-Tyr (IC50: 2.69 µM), Met-Lys-Tyr (7.26 µM), Ala-Lys-Tyr-Ser-Tyr (1.52 µM), and Leu-Arg-Tyr (5.06 µM).
Ozone Concentration in Leaf Intercellular Air Spaces Is Close to Zero (1989)

Transpiration and ozone uptake rates were measured simultaneously in sunflower leaves at different stomatal openings and various ozone concentrations. Ozone uptake rates were proportional to the ozone concentration up to 1500 nanoliters per liter. The leaf gas phase diffusion resistance (stomatal plus boundary layer) to water vapor was calculated and converted to the resistance to ozone multiplying it by the theoretical ratio of diffusion coefficients for water vapor and ozone in air (1.67). The ozone concentration in intercellular air spaces calculated from the ozone uptake rate and diffusion resistance to ozone scattered around zero. The ozone concentration in intercellular air spaces was measured directly by supplying ozone to the leaf from one side and measuring the equilibrium concentration above the other side, and it was found to be zero. The total leaf resistance to ozone was proportional to the gas phase resistance to water vapor with a coefficient of 1.68. It is concluded that ozone enters the leaf by diffusion through the stomata, and is rapidly decomposed in cell walls and plasmalemma.