gebhart/patrepeval huggingface dataset:
Go-Kart Spor Araçlarının Bilgisayar Destekli Şasi Tasarımı Ve Analizi (2001)

Bu çalışmada, günümüzde eğlence ve sporamaçlı olarak kullanılan arazi tipi ( Off-Road ) Go-Kart araçlarının önemli aksamlarından şasiincelenmiştir. Çalışmada CAD/CAM/CAEprogramları kullanılarak araçların şasi modellernesiyapılmış ve analizlere tabi tutulmuştur. Mevcut ş asimodeli oluşturulmuş ve şasitasarınıında önemli olanağırlık, rijitlik ve emniyet kriterleri incelenmiştir.Değişik çap, cidar kalınlığında profillerden oluşandeğişik boylarda ş asiler modellenmiş ve analizleretabi ·tutulmuştur. Analizde sonlu eleman tekniğikullanılarak modelin yükleme durumunda oluşangerilmeler ve deplasmanlar hesaplaonuştır. Sonolarak şasi tasarımda modifıkasyon yapılarakanalizlere tabi tutulmuş ve yük altında oluşangerilmeler ve deplasmanlar hesaplanarak mevcutşaside oluşan gerilmeler ve deplasmanlarlaarşılaştırılmıştır. Sonuç olarak aracın üzerinde0/oO,S&#039;lik bir ağırlık artmasıyla, meydana gelengerilmeler ve deplasmanlarda çap ve cidar kalınlığınabağlı olarak 0/oSO&#039;ye varan azalnıa sağlanmıştır. Buyöntem ile tasarım optiınize edilerek, şasiden dahayüksek verimlilik ve güvenlik alınmış dolayısıylaCAD/CAM/CAE sisteminin verimliliği ortayakonulmuştur.
A Security Architecture for e-Health Services (2008)

This paper presents an alternative way to secure communications in e-health. During the communication processes, users exchange different types of information with different levels of sensitivities. For example, communications between a doctor and a patient contain data of higher levels of sensitivities than communications between a social worker and a nurse. The different levels of the sensitivities of the information are secured by using different types of security processes. In this paper, these different communication types and different levels of data sensitivities in e-health are explained, the requirements for each type for communications are described and the use of the cryptography to secure the communication is discussed.
SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland (2022)

Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18-44 years; 32.3% of women giving birth in October 2021 had two doses of vaccine compared to 77.4% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95% CI 12.9-38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95% CI 5.1-6.2). Overall, 77.4% (3,833 out of 4,950; 95% CI 76.2-78.6) of SARS-CoV-2 infections, 90.9% (748 out of 823; 95% CI 88.7-92.7) of SARS-CoV-2 associated with hospital admission and 98% (102 out of 104; 95% CI 92.5-99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic.
Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors (2022)

Tumor infiltration by T cells profoundly affects cancer progression and responses to immunotherapy. However, the tumor immunosuppressive microenvironment can impair the induction, trafficking, and local activity of antitumor T cells. Here, we investigated whether intratumoral injection of virus-derived peptide epitopes could activate preexisting antiviral T cell responses locally and promote antitumor responses or antigen spreading. We focused on a mouse model of cytomegalovirus (CMV), a highly prevalent human infection that induces vigorous and durable T cell responses. Mice persistently infected with murine CMV (MCMV) were challenged with lung (TC-1), colon (MC-38), or melanoma (B16-F10) tumor cells. Intratumoral injection of MCMV-derived T cell epitopes triggered in situ and systemic expansion of their cognate, MCMV-specific CD4<sup>+</sup> or CD8<sup>+</sup> T cells. The MCMV CD8<sup>+</sup> T cell epitopes injected alone provoked arrest of tumor growth and some durable remissions. Intratumoral injection of MCMV CD4<sup>+</sup> T cell epitopes with polyinosinic acid:polycytidylic acid (pI:C) preferentially elicited tumor antigen-specific CD8<sup>+</sup> T cells, promoted tumor clearance, and conferred long-term protection against tumor rechallenge. Notably, secondary proliferation of MCMV-specific CD8<sup>+</sup> T cells correlated with better tumor control. Importantly, intratumoral injection of MCMV-derived CD8<sup>+</sup> T cell-peptide epitopes alone or CD4<sup>+</sup> T cell-peptide epitopes with pI:C induced potent adaptive and innate immune activation of the tumor microenvironment. Thus, CMV-derived peptide epitopes, delivered intratumorally, act as cytotoxic and immunotherapeutic agents to promote immediate tumor control and long-term antitumor immunity that could be used as a stand-alone therapy. The tumor antigen-agnostic nature of this approach makes it applicable across a broad range of solid tumors regardless of their origin.
Decreased Memory Performance in Healthy Humans Induced by Stress-Level Cortisol Treatment (1999)

Several days of exposure to cortisol at doses and plasma concentrations associated with physical and psychological stress in humans can-similar to pharmacological GC treatment-reversibly decrease specific elements of memory performance in otherwise healthy individuals.
Energy, Charge, and Spin Transport in Molecules and Self-Assembled Nanostructures Inspired by Photosynthesis (2006)

Electron transfer in biological molecules provides both insight and inspiration for developing chemical systems having similar functionality. Photosynthesis is an example of an integrated system in which light harvesting, photoinduced charge separation, and catalysis combine to carry out two thermodynamically demanding processes, the oxidation of water and the reduction of carbon dioxide. The development of artificial photosynthetic systems for solar energy conversion requires a fundamental understanding of electron-transfer reactions between organic molecules. Since these reactions most often involve single-electron transfers, the spin dynamics of photogenerated radical ion pairs provide important information on how the rates and efficiencies of these reactions depend on molecular structure. Given this knowledge, the design and synthesis of large integrated structures to carry out artificial photosynthesis is moving forward. An important approach to achieving this goal is the development of small, functional building blocks, having a minimum number of covalent bonds, which also have the appropriate molecular recognition sites to facilitate self-assembly into a complete, functional artificial photosynthetic system.
Maintenance therapy with low‐dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome (2010)

Azacitidine at 32 mg/m2 given for 5 days is safe and can be administered after allogeneic transplant for at least 4 cycles to heavily pretreated AML/MDS patients. The trial also suggested that this treatment may prolong event-free and overall survival, and that more cycles may be associated with greater benefit.
Secure container orchestration in the cloud (2019)

In the late few years, cloud computing has been moving towards becoming the predominant infrastructure paradigm because of its scale economy advantages. Consequently, a great deal of sensitive and valuable information has begun to inhabit the cloud environment. At the current stage, a large amount of organizations is yet to step to the public cloud world because, primarily, the loss of infrastructure ownership gives away control of such information, and that is generally perceived as a severe security risk.
Detection of Fundamental Shear Horizontal Guided Waves Using a Surface-Bonded Chirped Fiber-Bragg-Grating Fabry–Perot Interferometer (2018)

In this paper, detection of the fundamental shear horizontal (SH0) guided wave mode in a plate using a surface-bonded Fabry-Perot interferometer formed by a pair of tandem chirped fiber-Bragg-gratings (CFBG-FPI) has been investigated both theoretically and experimentally. Using the developed theory, the underlying mechanism that governs the sensor's response to SH0 mode is explored in detail. Then, the dependence on both the incident angle and frequency (or wavelength) of the SH0 wave is investigated. Owing to the pure shear strain induced by the SH0 mode, the fiber sensor shows a significantly different response in comparison to other ultrasonic waves, such as Lamb-type guided waves. Our results show that 1) the sensor is most sensitive to SH-type waves at an incident angle of around 45° and nonsensitive at the incident angles of 0° and 90° and 2) a minimum sensitivity is reached when the equivalent ultrasonic wavelength impinged on the fiber axis is equal to the effective length of the CFBG-FPI sensor; this effective length is close to the length of each CFBG.
Random Sampling for Seismic Acquisition (2011)

Seismic data acquired in land or marine acquisition is typically undersampled for both receivers and sources, and regularly distributed along parallel lines. The theory of compressive sampling considers that if data is undersampled, the seismic wavefield is better reconstructed if the measurements are randomly distributed. In this paper we investigate how random sampling can be implemented in different types of marine acquisition geometries. 3D finite-difference modeling data were generated to simulate acquisition geometries with regular and random sampling. We will present also a land synthetic data example for node type geometry to illustrate the benefit of random sampling for ground roll attenuation. (note: this example was not included in the abstract)
Laboratory-scale photoredox catalysis using hydrated electrons sustainably generated with a single green laser (2017)

The ruthenium-tris-bipyridyl dication as catalyst combined with the ascorbate dianion as bioavailable sacrificial donor provides the first regenerative source of hydrated electrons for chemical syntheses on millimolar scales. This electron generator is operated simply by illumination with a frequency-doubled Nd:YAG laser (532 nm) running at its normal repetition rate. Much more detailed information than by product studies alone was obtained by photokinetical characterization from submicroseconds (time-resolved laser flash photolysis) up to one hour (preparative photolysis). The experiments on short timescales established a reaction mechanism more complex than previously thought, and proved the catalytic action by unchanged concentration traces of the key transients over a number of flashes so large that the accumulated electron total surpassed the catalyst concentration many times. Preparative photolyses revealed that the sacrificial donor greatly enhances the catalyst stability through quenching the initial metal-to-ligand charge-transfer state before destructive dd states can be populated from it, such that the efficiency of this electron generator is no longer limited by catalyst decomposition but by electron scavenging by the accumulating oxidation products of the ascorbate. Applications covered dechlorinations of selected aliphatic and aromatic chlorides and the reduction of a model ketone. All these substrates are impervious to photoredox catalysts exhibiting lower reducing power than the hydrated electron, but the combination of an extremely negative standard potential and a long unquenched life allowed turnover numbers up to 1400 with our method.
Direct Electrochemistry of Cytochrome <i>c</i> at a Glassy Carbon Electrode Modified with Single-Wall Carbon Nanotubes (2002)

The electrochemistry of horse heart cytochrome c was studied by cyclic voltammetry at a glassy carbon electrode modified with single-wall carbon nanotubes (SWNTs). A pair of well-defined redox waves was obtained in cytochrome c aqueous solution at an activated SWNT film-modified electrode. The optimal conditions for activating the SWNT film-modified electrode has been determined. The electrode reaction of cytochrome c is a diffusion-controlled process. The peak current increases linearly with the concentration of cytochrome c in the range from 3.0 x 10(-5)-7.0 x 10(-4) M. The detection limit is 1.0 x 10(-5) M. The activated SWNT film was characterized by scanning electron microscopy. Furthermore, interaction of cytochrome c with adenine was characterized by electrochemical and spectral methods.
A high-linearity 50- Omega CMOS differential driver for ISDN applications (1991)

A CMOS differential line-driver amplifier that uses positive feedback in the input stage to give transconductance multiplication and pole-zero doublet insertion is reported. The gain-bandwidth product at 60 kHz is 30 MHz and the unity-gain frequency is 2.7 MHz. The circuit operates from a single 5-V power supply and can achieve a total harmonic distortion (THD) of -78 dB for a 6-V/sub pp/ differential output signal at 40 kHz and for a load of 100 Omega and/or 150 pF. For the same measuring condition but with a load of 50 Omega and/or 150 pF, the THD is -73 dB. A power supply rejection of more than 76 dB up to 150 kHz was obtained. The chip occupies an area of 1200 mil/sup 2/ in a 1.5- mu m CMOS technology and dissipates 20 mW.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reliability assessment of a novel cervical spine deformity classification system (2015)

The proposed classification provides a mechanism to assess CSD within the framework of global spinopelvic malalignment and clinically relevant parameters. The intra- and interobserver reliabilities suggest moderate agreement and serve as the basis for subsequent improvement and study of the proposed classification.
Differential effects of heparin and low molecular weight heparin on osteoblastogenesis and adipogenesis in vitro (2004)

We have previously demonstrated that heparin produces cancellous bone loss in rats due in part to a decrease in the number of osteoblasts lining the trabecular bone surface. In the present study, we use a stromal-derived cell culture system together with measurements of alkaline phosphatase (ALP) activity, to compare the effects of heparin and the low molecular weight heparin (LMWH), Fragmin, on osteoblast differentiation in vitro. In addition, we examined the possibility that both heparin and LMWH can induce adipogenesis in our stromal cell culture system. Both heparin and LMWH were found to produce a statistically significant (P < 0.01) and concentration-dependent decrease in the number of osteoblasts while increasing the number of adipocytes. When the effects of gravimetrically equivalent amounts of heparin and LMWH were compared, heparin had a 4-fold greater effect than LMWH. In contrast to heparin, N-desulfated heparin was found to have minimal effects on both osteoblast and adipocyte differentiation indicating that the heparin effect is not only chain-length dependent but also charge-dependent. The observation that LMWH has less of an effect on bone formation than heparin is compatible with the results of clinical trials indicating that LMWH produces less bone loss after long-term administration.
FlowFurl: A flow-level routing for faulty data center networks (2016)

Recent Data center network topologies put forward multiple paths between the end hosts to provide high bisection bandwidth. For the sake of efficient utilization of multiple paths many load balancing techniques are proposed in the literature. These load balancing proposals mainly deal with distribution of traffic among multiple paths. While balancing the traffic among multiple paths, few proposals also take care of congestion. Flow level solutions avoid flow splitting to preventing the packet reordering at the destination. These solutions try for rerouting (change the path) of flow dynamically based on the feedback received from the network. In case of link failures rerouting of the flow, based on the queue size of the remote switch alone may be sub-optimal. This paper proposes FlowFurl, an adaptive, distributed, end host driven and flow level load balancing technique. This adaptive routing technique supports dynamic flow-to-path assignment. This flow-to-path assignment is not only based on the congestion at the switch, but also the status of the links along the path. The simulation results show that utilizing connectivity information with congestion information can help to design better load balancing scheme.
Large-scale nanopatterning of metal surfaces by target-ion induced plasma sputtering (TIPS) (2016)

Target-ion Induced Plasma Sputtering (TIPS) can produce large-scale, self-assembled nanopatterns on metals and alloys in one step at low cost.
The Freshness Preservation Technique of Codonopsis tangshen (2009)

The different vacuum plastic packaging methods were tested to find the effective freshness preservation method of Codonopsis tangshen.The results showed that the effective freshness preservation method for above 60 d includes vacuum plastic packaging under ambient temperature and reducing oxygen concentration by adding citric acid and vacuuming.The maximum water content of dry Codonopsis tangshen.should be controlled below 13% in its vacuum packaging and its quality guarantee period can be longer by reducing oxygen concentration with the aid of a vacuuming method.
Performance of Different Proxy Concepts in UMTS Networks (2004)

Abstract It is well known that the large round trip time and the highly variable delay in a cellular network may degrade the performance of TCP. Many concepts have been proposed to improve this situation, including performance enhancing proxies (PEPs). One important class of PEPs are split connection proxies, which terminate a connection from a server in the Internet in a host close to the Radio Access Network (RAN) and establish a second connection towards the mobile User Equipment (UE). This connection splitting can be done either purely on the transport layer (TCP proxy) or on the application layer (HTTP proxy in the case of web traffic). While it is clear that an application layer proxy also infers the splitting of an underlying transport layer connection, the performance of applications may be essentially different for both approaches. In this paper, we first study the general impact of a split connection proxy on TCP bulk data transfer. We then focus on the case of web traffic and investigate the TCP connection behavior of the Mozilla web browser. Based on this, we study the performance of TCP and HTTP proxies in UMTS networks under different scenarios and for different HTTP configurations. 1
Improved Production of Medium-Chain-Length Polyhydroxyalkanoates in Glucose-Based Fed-Batch Cultivations of Metabolically Engineered Pseudomonas putida Strains (2014)

One of the major challenges in metabolic engineering for enhanced synthesis of value-added chemicals is to design and develop new strains that can be translated into well-controlled fermentation processes using bioreactors. The aim of this study was to assess the influence of various fed-batch strategies in the performance of metabolically engineered Pseudomonas putida strains, Δgcd and Δgcd-pgl, for improving production of medium-chain-length polyhydroxyalkanoates (mcl-PHAs) using glucose as the only carbon source. First we developed a fed-batch process that comprised an initial phase of biomass accumulation based on an exponential feeding carbon-limited strategy. For the mcl-PHA accumulation stage, three induction techniques were tested under nitrogen limitation. The substrate-pulse feeding was more efficient than the constant-feeding approach to promote the accumulation of the desirable product. Nonetheless, the most efficient approach for maximum PHA synthesis was the application of a dissolved-oxygen-stat feeding strategy (DO-stat), where P. putida Δgcd mutant strain showed a final PHA content and specific PHA productivity of 67% and 0.83 g·l(-1)·h(-1), respectively. To our knowledge, this mcl-PHA titer is the highest value that has been ever reported using glucose as the sole carbon and energy source. Our results also highlighted the effect of different fed-batch strategies upon the extent of realization of the intended metabolic modification of the mutant strains.
Nanosuspension: An approach to enhance solubility of drugs (2011)

One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media, belonging to BCS class II as classified by biopharmaceutical classification system. Formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability, but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy. This review article describes the preparation methods, characterization, and applications of the nanosuspension.
Decellularized Human Cornea for Reconstructing the Corneal Epithelium and Anterior Stroma (2011)

In this project, we strived to develop a decellularized human cornea to use as a scaffold for reconstructing the corneal epithelium and anterior stroma. Human cadaver corneas were decellularized by five different methods, including detergent- and nondetergent-based approaches. The success of each method on the removal of cells from the cornea was investigated. The structural integrity of decellularized corneas was compared with the native cornea by electron microscopy. The integrity of the basement membrane of the epithelium was analyzed by histology and by the expression of collagen type IV, laminin, and fibronectin. Finally, the ability of the decellularized corneas to support the growth of human corneal epithelial cells and fibroblasts was assessed in vitro. Corneas processed using Triton X-100, liquid nitrogen, and poly(ethylene glycol) resulted in incomplete removal of cellular material. Corneas processed with the use of sodium dodecyl sulfate (SDS) or with sodium chloride (NaCl) plus nucleases successfully removed all cellular material; however, only the NaCl plus nuclease treatment kept the epithelial basement membrane completely intact. Corneas processed with NaCl plus nuclease supported both fibroblast and epithelial cell growth in vitro, while corneas treated with SDS supported the growth of only fibroblasts and not epithelial cells. Decellularized human corneas provide a scaffold that can support the growth of corneal epithelial cells and stromal fibroblasts. This approach may be useful for reconstructing the anterior cornea and limbus using autologous cells.
Tumor necrosis factor induces acute phase proteins in rats. (1988)

Inoculation of WAG rats with recombinant mouse tumor necrosis factor results in a rapid and marked increase in several acute phase proteins in the serum (haptoglobin, alpha 1 acid glycoprotein, alpha 2 macroglobulin) and in the plasma (fibrinogen). We conclude that TNF may play an important role in the inflammatory response in vivo and possibly in the pathogenesis of inflammatory disorders.