gebhart/patrepeval huggingface dataset:
An intelligent indoor positioning system based on pedestrian directional signage object detection: a case study of Taipei Main Station (2019)

Indoor positioning technologies have gained great interest from both industry and academia. Variety of services and applications can be built based on the availability and accessibility of indoor positioning information, for example indoor navigation and various location-based services. Different approaches have been proposed to provide indoor positioning information to users, in which an underlying system infrastructure is usually assumed to be well deployed in advance to provide the position information to users. Among many others, one common strategy is to deploy a bunch of active sensor nodes, such as WiFi APs and Bluetooth transceivers, to the indoor environment to serve as reference landmarks. The user's current location can thus be obtained directly or indirectly according to the active sensor signals collected by the user. Different from conventional infrastructure-based approaches, which put additional sensor devices to the environment, we utilize available objects in the environment as location landmarks. Leveraging wildly available smartphone devices as customer premises equipment to the user and the cutting-edge deep-learning technology, we investigate the feasibility of an infrastructure-free intelligent indoor positioning system based on visual information only. The proposed scheme has been verified by a real case study, which is to provide indoor positioning information to users in Taipei Main Station, one of the busiest transportation stations in the world. We use available pedestrian directional signage as location landmarks, which include all of the 52 pedestrian directional signs in the testing area. The Google Objection Detection framework is applied for detection and recognition of the pedestrian directional sign. According to the experimental results, we have shown that the proposed scheme can achieve as high as 98% accuracy to successfully identify the 52 pedestrian directional signs for the three test data sets which include 6,341 test images totally. Detailed discussions of the system design and the experiments are also presented in the paper.
Experimental Investigation of the Penetration Characteristics of Curved CFRP Composite Laminates (2004)

CFRP composite laminates have wide application in automobiles, aerospace vehicles and ships for light-weight structures. The shape of normal structure is curved shell with various curvature radius. When these structures are subjected to external force, the response and behavior of curved shells are different from those of flat-plate. The objective of this paper is to investigate the effect of curvature on the penetration characteristics and the discussion on stacking sequences and thickness of shells. First of all, when the specimen is subjected to transverse impact by a steel ball, the velocity of the steel ball was measured both before and after impact by determining the time for it to pass two ballistic-screen sensors located a known distance apart. And then, the critical penetration energy increased as the curvature increased. The critical penetration energy of [0_2/90_2]_s and [0_3/90_3]_s was higher than [0/90_2/0]_s and [0_2/90_2/0]_s.
Improving Speech Recognition Using Semantic and Reference Features in a Multimodal Dialog System (2007)

Current Speech-based dialog system undergo a practical problem; a speech recognizer is defective due to inevitable errors. Even in multimodal dialog systems, which have multiple input channels, errors in the speech recognition are a major problem because speech contains a large portion of user's intention. In this paper, we propose a re-ranking method to improve the performance of speech recognition in a multimodal dialog system. To re-rank the n-best speech recognition hypotheses, we use the multimodal understanding features that are orthogonal to the speech as well as the speech recognizer features. We demonstrate our method to smart home domain, and the results show that the multimodal understanding features are promising in overcoming many speech errors.
Distributed architectures for pen-based input and diagram recognition (1996)

We present a system supporting pen-based input and diagram recognition that employs a personal digital assistant (PDA) as an intelligent input device for the system. Functionality is distributed between the PDA and the main computer, with the PDA performing low-level shape recognition and editing functions, and the back-end computer performing high-level recognition functions, including recognition of spatial relations between picture elements. This organization provides a number of advantages over conventional pen-based systems employing simple digitizing tablets. It provides the opportunity to use hardware specially designed for shape recognition and editing in a general diagram recognition system, it allows for improved performance through parallel processing, and it allows diagram entry to be performed remotely through use of the PDA front end in the field, with recognized shapes subsequently downloaded to the main diagram recognizer. We discuss the overall organization of the system, as well as the individual pieces and the communication between them, and describe two ongoing projects employing this architecture.
p21 <sup>cιp/WAF</sup> is a key regulator of long‐term radiation damage in mesenchyme‐derived tissues (2010)

ABSTRACT This study aimed to determine the mechanisms responsible for long‐term tissue damage following radiation injury. We irradiated p21‐knockout (p21 _/_ ) and wild‐type (WT) mice and determined the long‐term deleterious effects of this intervention on mesenchyme‐derived tissues. In addition, we explored the mechanisms of radiation‐induced mesenchymal stem cell (MSC) dysfunction in isolated bone marrow‐derived cells. p21 expression was chronically elevated < 200‐fold in irradiated tissues. Loss of p21 function resulted in a >4‐fold increase in the number of skin MSCs remaining after radiation. p21 –/– mice had significantly less radiation damage, including 6‐fold less scarring, 40% increased growth potential, and 4‐fold more hypertrophic chondro‐cytes in the epiphyseal plate ( P <0.01). Irradiated p21 _/_ MSCs had 4‐fold increased potential for bone or fat differentiation, 4‐fold greater proliferation rate, and nearly 7‐fold lower senescence as compared to WT MSCs ( P <0.01). Ectopic expression of p21 in knockout cells decreased proliferation and differentiation potential and recapitulated the WT phenotype. Loss of p21 function markedly decreases the deleterious effects of radiation injury in mesenchyme‐derived tissues and preserves tissue‐derived MSCs. In addition, p21 is a critical regulator of MSC proliferation, differentiation, and senescence both at baseline and in response to radiation.—Mehrara, B. J., Avraham, T., Soares, M., Fernandez, J. G., Yan, A., Zampell, J. C., Andrade, V. P., Cordeiro, A. P., Sorrento, C. M. p21 cip/WAF is a key regulator of long‐term radiation damage in mesenchyme‐derived tissues. FASEB J. 24, 4877–4888 (2010). www.fasebj.org
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates (2018)

Transcellular propagation of protein aggregate "seeds" has been proposed to mediate the progression of neurodegenerative diseases in tauopathies and α-synucleinopathies. We previously reported that tau and α-synuclein aggregates bind heparan sulfate proteoglycans (HSPGs) on the cell surface, promoting cellular uptake and intracellular seeding. However, the specificity and binding mode of these protein aggregates to HSPGs remain unknown. Here, we measured direct interaction with modified heparins to determine the size and sulfation requirements for tau, α-synuclein, and β-amyloid (Aβ) aggregate binding to glycosaminoglycans (GAGs). Varying the GAG length and sulfation patterns, we next conducted competition studies with heparin derivatives in cell-based assays. Tau aggregates required a precise GAG architecture with defined sulfate moieties in the <i>N</i>- and 6-<i>O</i>-positions, whereas the binding of α-synuclein and Aβ aggregates was less stringent. To determine the genes required for aggregate uptake, we used CRISPR/Cas9 to individually knock out the major genes of the HSPG synthesis pathway in HEK293T cells. Knockouts of the extension enzymes exostosin 1 (<i>EXT1</i>), exostosin 2 (<i>EXT2</i>), and exostosin-like 3 (<i>EXTL3</i>), as well as <i>N</i>-sulfotransferase (<i>NDST1</i>) or 6-<i>O</i>-sulfotransferase (<i>HS6ST2</i>) significantly reduced tau uptake, consistent with our biochemical findings, and knockouts of <i>EXT1, EXT2, EXTL3</i>, or <i>NDST1,</i> but not <i>HS6ST2</i> reduced α-synuclein uptake. In summary, tau aggregates display specific interactions with HSPGs that depend on GAG length and sulfate moiety position, whereas α-synuclein and Aβ aggregates exhibit more flexible interactions with HSPGs. These principles may inform the development of mechanism-based therapies to block transcellular propagation of amyloid protein-based pathologies.
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF (2021)

In the fibrotic lung, dual inhibition of integrins α<sub>v</sub>β<sub>6</sub> and α<sub>v</sub>β<sub>1</sub> offers the optimal approach for blocking fibrogenesis resulting from integrin-mediated activation of transforming growth factor-β.
Heart Failure Performance Measures and Outcomes (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The PowerPC 603 microprocessor: a low-power design for portable applications (2002)

The PowerPC 603 microprocessor is a low-power implementation of the PowerPC architecture. The superscalar organization includes dynamic localized shutdown of execution units to reduce normal-mode power consumption. Three levels of static low-power operation are software programmable for system power management. The 603 PLL (phase lock loop) is capable of generating an internal processor clock at 1/spl times/, 2/spl times/, 3/spl times/ or 4/spl times/ the system clock speed to allow control of system power while maintaining processor performance. Various design features optimize the 603 for both power and performance, creating an ideal microprocessor solution for portable applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Substrate Specificity of Fpg (MutM) and hOGG1, Two Repair Glycosylases (2007)

8-Oxo-2‘-deoxyguanosine (OdG) is a prominent DNA damaged nucleotide that is a known promutagen and has been linked to cancer and aging. To limit the harmful effects of OdG, E. coli and human cells have evolved repair glycosylases, Fpg (MutM) and hOGG, respectively, that remove the 8-oxoguanine base from OdG:dC base pairs. Though much research has focused on the mode of substrate recognition by these enzymes, many unanswered questions have remained. Herein we report that both enzymes are active on a wide array of dG/OdG analogues that vary in their composition within the imidazole ring. These findings suggest that Fpg and hOGG recognize their substrate, at least in part, based on the lack of a lone pair at a fully sp2-hybridized N7.
Digital Workflow for Prosthetically Driven Implants Placement and Digital Cross Mounting: A Retrospective Case Series (2022)

Fully digital workflow in implant dentistry is ever increasing. Treatment of partial edentulous cases is well-documented; nevertheless, complete edentulous cases are still a challenge. To present several innovations in the treatment of complete edentulous patients using digital solutions, both for implant placement and restoration delivery, was the objective of this study. It was designed as a retrospective case series study, aimed to tune further research with larger sample size, and a longer follow-up. Patients requiring complete, implant-supported restoration were asked to participate in this study. Enrolled patients were treated with four implants, immediate loading and a definitive complete arch restoration. Patients were treated using computer-assisted, template-based surgery. Multi-piece surgical templates were used to accurately place the implants, to manage the bone if needed and to make immediate loading procedure quicker and easier. After osseointegration period, definitive, extra-oral, digital impressions were taken using newly developed scan analogs, connected in the patient mouth using temporary cylinders and stabilized by means of the low-shrinkage, flowable, resin composite. Outcomes were implant and prosthesis survival rate, complications, accuracy, and patient satisfaction. Radiographic evaluation performed with a preliminary, radiopaque aluminum try-in, was used to test the accuracy of the digital impressions. Overall, 20 implants were placed in five patients. All the implants osseointegrated without complications. One impression was taken a second time due to inaccuracy of the aluminum tray-in. Finally, all of the patients were completely satisfied with both surgical and prosthetic procedures. Within the limitations of this case series, multi-piece surgical templates showed promising results improving the clinician’s confidence in the case of bone reduction, post-extractive implants and immediate loading. The prosthetic template increased the trueness of the digital impression for complete edentulous patients. Finally, even if an impression was performed again, the scan-analog used for extra-oral chair-side digital impressions seemed to be a promising tool. Continuous improvements and further study are needed to confirm these preliminary results.
Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood (2009)

The absorption efficiency of any drug in blood is of prime importance. Compounds having the general formula: K(n)[M(FO)(2)(H(2)O)(2)] . xH(2)O, where (M = Cu(II) or Fe(III), n = 2 or 1, FO = folate anion, x = 2 or 3 with respect), were prepared, and their absorption efficiency in rodent's blood was determined. The obtained compounds were characterized by elemental analysis, infrared as well as thermogravimetric analysis and polarization of light. The results suggest that the two folate complexes were formed in 1 : 2 molar ratio (metal : folic acid) which acted as a bidentate ligand through both carboxylic groups. Polarization of light proved that the folate complexes have symmetric geometry. Biological application proved that Cu(II) and Fe(III) complexes were absorbed more efficiently in rodent blood than folic acid itself.
Comparison of various kinds of edge elements for electromagnetic field analysis (1996)

A new type of 2nd order edge element is proposed. Various kinds of triangular edge elements for 2-D electromagnetic field analysis are discussed in terms of the definition of vectorial variables, shape functions and accuracy. It is illustrated that the new edge element is more favourable than other 2nd order edge elements from the standpoints of accuracy and selection of variables. The new element can be extended easily to higher order elements and to 3-D elements.
Characterization of <i>Arabidopsis</i> decapping proteins AtDCP1 and AtDCP2, which are essential for post‐embryonic development (2007)

Although decapping is an important process in eukaryotic mRNA turnover, little is known about this process in plants. Here, we identified Arabidopsis thaliana decapping proteins AtDCP1 and AtDCP2 and showed that (I) AtDCP2 is an active decapping enzyme, (II) AtDCP1 interacts with itself, (III) AtDCP1 and AtDCP2 are localized to cytoplasmic foci (putative Arabidopsis processing body), and (IV) AtDCP1 and AtDCP2 are essential for post-embryonic development. Our findings provide new insights into the role of decapping-dependent mRNA turnover.
Terahertz Polarization Detector Based on PMMA Grating Pipe (2016)

In this paper, we propose and experimentally demonstrate a method to realize a polarization detector by using a commercially available polymethyl methacrylate (PMMA) pipe. An asymmetric polarization-related structure is fabricated by etching different grating structures on the external surface of the pipe. The results show that when the pipe rotates up to 90, the peak of the transmission spectrum can evidently shift towards the low frequency, which means the pipe with grating structures can serve as a polarization detector. This design possesses the merits of a simple structure and easy fabrication.
Production of lactic acid and energy metabolism in vascular smooth muscle: effect of dichloroacetate (1995)

Vascular smooth muscle metabolism is characterized by substantial production of lactic acid even under fully oxygenated conditions. The role the aerobic production of lactate plays in the energetics of smooth muscle is obscure and was investigated in this study. Helical strips of porcine carotid arteries were incubated in medium containing 1 mM dichloroacetate (DCA), an agent that stimulates pyruvate dehydrogenase and promotes the oxidation of glucose. Lactate production in resting muscle was decreased in the presence of DCA (0.033 +/- 0.006 vs. 0.111 +/- 0.014 mumol.g-1.min-1, P < 0.02), indicating diversion of glucose metabolism from lactate production to enhanced glucose oxidation. This was associated with reduction in the level of ATP+phosphocreatine (PCr) (0.99 +/- 0.01 vs. 1.40 +/- 0.09 mumol/g, P < 0.05) and cataplerosis of the tricarboxylic acid (TCA) cycle. Contraction by KCl was also associated with reduced lactate production in the presence of DCA (0.086 +/- 0.017 vs. 0.20 +/- 0.002 mumol.g-1.min-1, P < 0.01), but ATP+PCr normalized, and there was anaplerosis of the TCA cycle. Glycogen in control arteries declined by approximately 1.3 mumol/g over 30 min K+ contraction but was unchanged in the presence of DCA. By calculation, the glycogen spared could be accounted for by the quantity of glucose diverted from lactate production to glucose oxidation during contraction. It is concluded that the aerobic production of lactate is a mechanism affording optimal coordination and modulation of glucose supply and oxidative energy production with energy demand.
An overview of various labeled assays used in medical laboratory diagnosis. Immune and non-immune assays. (2010)

In this review, some light is thrown on various labeled immunoassays that depend on antigen-antibody (Ag-Ab) reactions, including immunofluorescence, radioimmunoassay, and enzyme immunoassay (EIA or ELISA). Their definitions, principles, and applications are described, then they are discussed chronologically to show their stepwise development that led finally to full automation. Enzyme labeled immunoblot assays (Western blot, blot spot, and recombinant immunoblot assay), and luminescence (bioluminescence and chemiluminescence) are also discussed chronologically. Labeled assays, that do not involve Ag-Ab reaction but rather, utilizing biotin-streptavidin (BS) interaction and probe-target DNA interaction, are described, together with their applications for DNA/RNA detection and genotyping. Finally, included in the discussion were some luminescent labeled techniques that utilize the immune Ag-Ab reaction together with non-immune BS reaction, such as the luminescent oxygen channeling immunoassay, and its commercialized AlphaLISA, both eliminate the washing steps without sacrificing high sensitivity, or wide dynamic range.
THE EFFECTS OF GOAL‐CONTINGENT PAYMENT ON THE PERFORMANCE OF A COMPLEX TASK<sup>1</sup> (1984)

Using a highly complex, computerized decision‐making task, 56 university students participated in a six‐week long, repeated measures, goal‐setting project, involving different payment systems. Results indicated that goal‐contingent payment is superior to hourly payment in influencing performance, even though the perceived valence of payment and the actual amount paid is substantially less. Discussion pointed out the limitations of the findings, including some basic equivocality in determining why such results were obtained. Discussion then focused on the implications of the findings for future investigations.
Finding optimal control strategies for invasive species: a density‐structured model for<i>Spartina alterniflora</i> (2004)

Summary There are very few general guidelines available to improve the process of eradicating invasive species. We addressed the basic question of whether it is more efficient to prioritize the removal of outliers or core populations of an invasive grass, Spartina alterniflora . We used a structured model in which the population of the invasive species is partitioned into different classes based on local conspecific density in order to investigate density‐based eradication strategies. The Spartina population at a Pacific coast estuary in Washington state, USA, is subject to an Allee effect: at low density plants produce fewer propagules than in high‐density coalesced meadows. Plants at low density, however, are able to spread faster vegetatively. We used a genetic algorithm to find the optimal division of resources between removal of high‐density and low‐density plants. We explored the consequences of the Allee effect, contrasting financial budgets available for control operations and the inclusion of seedling control in addition to the control of mature plants. We found that the optimal strategy was dependent on the annual budget available for control. At low and medium budgets, it was necessary to remove the low‐density plants first to achieve eradication, but if more money was available then the optimal strategy was to prioritize high‐density areas. Without an Allee effect the optimal strategy would always be to prioritize the removal of fast‐growing, low‐density sub‐populations. Seedling control did not change the optimal strategy but did, in some cases, reduce the cost of eradication. Synthesis and applications . Given the uncertainty in future budgets allocated for control of invasive Spartina , we recommend a strategy that prioritizes the removal of low‐density subpopulations of S. alterniflora over high‐density subpopulations. The Allee effect in this system is not sufficiently strong to outweigh the importance of the rapid vegetative spread of the plants at low density.
Bioassay of Solubilized <i>Bacillus thuringiensis</i> var. <i>Israelensis</i> Crystals by Attachment to Latex Beads (1984)

Solubilized crystals of Bacillus thuringiensis var. israelensis were 7000 times less toxic to Aedes aegypti larvae than intact crystals, presumably because mosquito larvae are filter feeders and selectively concentrate particles while excluding water and soluble molecules. A procedure is described whereby soluble toxins are adsorbed to 0.8-micrometer latex beads, with retention of toxicity. The latex bead assay should make it possible to analyze the structure and mode of action of the mosquito toxin.