gebhart/patrepeval huggingface dataset:
The action of defined oxygen-centred free radicals on human low-density lipoprotein (1989)

The effects of defined oxygen-centred free radicals on human low-density lipoprotein (LDL) structure and receptor affinity are discussed in relation to the mechanisms of cell-mediated oxidative modification of LDL. Both hydroxyl (OH.) and hydroperoxyl (HO2.) radicals caused depletion of endogenous alpha-tocopherol and formation of hydroperoxides. Superoxide (O2-.) radicals produced only very limited oxidation, but could potentiate oxidation stimulated by the addition of Cu2+. All these radicals enhanced the net negative charge of intact LDL and induced fragmentation of apolipoprotein B-100 (apo B). OH. also caused cross-linking of apo B. Radical attack decreased the affinity of LDL for the fibroblast apo B/E receptor, but did not enhance its endocytosis by mouse macrophages.
Institutions (1991)

Institutions are the humanly devised constraints that structure political, economic, and social interaction. They consist of both informal constraints (sanctions, taboos, customs, traditions, and codes of conduct), and formal rules (constitutions, laws, property rights). Throughout history, institutions have been devised by human beings to create order and reduce uncertainty in exchange. Together with the standard constraints of economics they define the choice set and therefore determine transaction and production costs and hence the profitability and feasibility of engaging in economic activity. They evolve incrementally, connecting the past with the present and the future; history in consequence is largely a story of institutional evolution in which the historical performance of economies can only be understood as a part of a sequential story. Institutions provide the incentive structure of an economy; as that structure evolves, it shapes the direction of economic change towards growth, stagnation, or decline. In this essay, I intend to elaborate on the role of institutions in the performance of economies and illustrate my analysis from economic history.
Am<i>tyr</i>1 (2000)

Biogenic amine receptors are involved in the regulation and modulation of various physiological and behavioral processes in both vertebrates and invertebrates. We have cloned a member of this gene family from the CNS of the honeybee, Apis mellifera. The deduced amino acid sequence is homologous to tyramine receptors cloned from Locusta migratoria and Drosophila melanogaster as well as to an octopamine receptor cloned from Heliothis virescens. Functional properties of the honeybee receptor were studied in stably transfected human embryonic kidney 293 cells. Tyramine reduced forskolin-induced cyclic AMP production in a dose-dependent manner with an EC50 of approximately 130 nM. A similar effect of tyramine was observed in membrane homogenates of honeybee brains. Octopamine also reduced cyclic AMP production in the transfected cell line but was both less potent (EC50 of approximately 3 microM) and less efficacious than tyramine. Receptor-encoding mRNA has a wide-spread distribution in the brain and subesophageal ganglion of the honeybee, suggesting that this tyramine receptor is involved in sensory signal processing as well as in higher-order brain functions.
Compact diode-laser-pumped quantum light source based on four-wave mixing in hot rubidium vapor (2012)

Using a nondegenerate four-wave mixing process in hot rubidium vapor, we demonstrate a compact diode-laser-pumped system for the generation of intensity-difference squeezing down to 8 kHz with a maximum squeezing of -7 dB. To the best of our knowledge, this is the first demonstration of kilohertz-level intensity-difference squeezing using a semiconductor laser as the pump source. This scheme is of interest for experiments involving atomic ensembles, quantum communications, and precision measurements. The diode-laser-pumped system would extend the range of possible applications for squeezing due to its low cost, ease of operation, and ease of integration.
Hybrid Iteration Control on LDPC Decoders (2010)

Stopping criteria for the iterative decoding of low-density parity-check codes are considered. For a successful decoding task an inherent stopping criterion is used: the fulfillment of all parity-check constraints. For an unsuccessful task the decoder usually completes a preset maximum number of iterations. Proper iteration control is required to save energy and time on unnecessary decoder operation when processing undecodable blocks. In this paper we propose an iteration control policy that is driven by the combination of two decision metrics. One is the number of satisfied parity-check constraints and the second one is provided by a specific message computation kernel: the Self-Corrected Min-Sum decoding algorithm. Our results show that this hybrid control policy offers superior performance in terms of energy efficiency compared to previously proposed techniques. In addition we show empirically how stopping criteria should be tuned as a function of false alarm and missed detection rates.
Multi-resolution based hybrid spatiotemporal compression of encrypted videos (2009)

Compression of encrypted data can be viewed as a special case of distributed source coding and can be achieved by applying Slepian-Wolf coding. However, how to compress the encrypted video efficiently remains a challenging problem especially for those videos with irregular high motion. This paper proposes a novel multi-resolution based approach which makes it possible not only to effectively derive the temporal side information from previous frames, but also to generate the spatial side information by having partial access to the current frame. The spatial and temporal side information can then be integrated adaptively to facilitate the compression. Simulation results show that the proposed scheme significantly outperforms other schemes, especially for those video clips with irregular high motion.
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase (2006)

Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases glucose disposal without affecting the complete suppression of endogenous glucose production during a hyperinsulinemic-euglycemic clamp in healthy humans. Because skeletal muscle accounts for most of the insulin-stimulated glucose disposal in vivo, we examined the mechanism(s) by which IL-6 may affect muscle metabolism using L6 myotubes. IL-6 treatment increased fatty acid oxidation, basal and insulin-stimulated glucose uptake, and translocation of GLUT4 to the plasma membrane. Furthermore, IL-6 rapidly and markedly increased AMP-activated protein kinase (AMPK). To determine whether the activation of AMPK mediated cellular metabolic events, we conducted experiments using L6 myotubes infected with dominant-negative AMPK alpha-subunit. The effects described above were abrogated in AMPK dominant-negative-infected cells. Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK.
Wafer-Level Thermocompression Bonds (2003)

Thermocompression bonding of gold is a promising technique for achieving low temperature, wafer-level bonding without the application of an electric field or complicated pre-bond cleaning procedure. The presence of a ductile layer influences the fracture behavior of the bonds. The fabrication process was described. In addition, the effect of plasticity was explored by varying the gold bonding thickness between 0.23 to 1.4 µm. Wafers were bonded at 300°C and two different pressures: 1.25 and 7 MPa. The bond toughness of the specimens were characterized using a four-point bend delamination technique. Cohesive failure was found to be the dominant fracture mode in the thicker films. Bonds made with thin gold films failed adhesively and at lower strain energy release rates.
High Incident Photon‐to‐Current Conversion Efficiency of p‐Type Dye‐Sensitized Solar Cells Based on NiO and Organic Chromophores (2009)

The synthesis and characterization of an organic dye, P4, together with its performance in p-type dye-sensitized solar cells (DSSCs) is presented. A solar-cell device based on P4 and an electrolyte that contains the I−/I3− couple in acetonitrile yielded an IPCE value of 44% on a transparent NiO film only 1–1.4 μm thick, the highest value obtained so far.
Rapid activation of the sympathetic nervous system following coronary artery occlusion: relationship to infarct size, site, and haemodynamic impact (1979)

In order to define the temporal and quantitative relationship between the plasma concentrations of catecholamines and the extent and location of myocardial infarction, conscious dogs underwent left anterior descending or circumflex coronary occlusion with continuous haemodynamic monitoring. Plasma noradrenaline and adrenaline concentrations were measured by the serial isotope derivative method and infarction size by the creatine kinase depletion method. Rapid increases in plasma catecholamines were seen within 1 min of coronary occlusion. Within the first hour profound elevations of plasma adrenaline (10 fold) and noradrenaline (3 fold) occurred, with peak adrenaline and noradrenaline levels correlated to infarction size determined 24 h later in anterior (r =0.71; r =0.83) and posterior (r =0.89, r =0.78) infarctions. Cardiac output and mean systemic arterial blood pressure were inversely related to adrenaline (r =0.88, r =0.73) and noradrenaline (r =0.94, r =0.73) and deterioration in haemodynamics was always noted simultaneously with or preceding increases in plasma catecholamine concentrations. There were no significant differences in plasma catecholamines dependent on location of infarction. Thus, coronary occlusion in the conscious dog results in immediate haemodynamic deterioration and activation of the sympathetic nervous system, with a strong correlation between the two suggesting that activation of the sympathetic nervous system by haemodynamic reflexes may be of importance in the conscious canine model. The degree of autonomic activation within the first hour after occlusion appears to be related to the ultimate size of infarction, possibly because of the relationship between impairment of ventricular performance and infarct size.
Traffic-Driven Spectrum Allocation in Heterogeneous Networks (2015)

Next generation cellular networks will be heterogeneous with dense deployment of small cells in order to deliver high data rate per unit area. Traffic variations are more pronounced in a small cell, which in turn lead to more dynamic interference to other cells. It is crucial to adapt radio resource management to traffic conditions in such a heterogeneous network (HetNet). This paper studies the optimization of spectrum allocation in HetNets on a relatively slow timescale based on average traffic and channel conditions (typically over seconds or minutes). Specifically, in a cluster with n base transceiver stations (BTSs), the optimal partition of the spectrum into 2n segments is determined, corresponding to all possible spectrum reuse patterns in the downlink. Each BTS's traffic is modeled using a queue with Poisson arrivals, the service rate of which is a linear function of the combined bandwidth of all assigned spectrum segments. With the system average packet sojourn time as the objective, a convex optimization problem is first formulated, where it is shown that the optimal allocation divides the spectrum into at most n segments. A second, refined model is then proposed to address queue interactions due to interference, where the corresponding optimal allocation problem admits an efficient suboptimal solution. Both allocation schemes attain the entire throughput region of a given network. Simulation results show the two schemes perform similarly in the heavy-traffic regime, in which case they significantly outperform both the orthogonal allocation and the full-frequency-reuse allocation. The refined allocation shows the best performance under all traffic conditions.
In‐Situ Nanostructuring and Stabilization of Polycrystalline Copper by an Organic Salt Additive Promotes Electrocatalytic CO<sub>2</sub> Reduction to Ethylene (2019)

Bridging homogeneous molecular systems with heterogeneous catalysts is a promising approach for the development of new electrodes, combining the advantages of both approaches. In the context of CO<sub>2</sub> electroreduction, molecular enhancement of planar copper electrodes has enabled promising advancement towards high Faradaic efficiencies for multicarbon products. Besides, nanostructured copper electrodes have also demonstrated enhanced performance at comparatively low overpotentials. Herein, we report a novel and convenient method for nanostructuring copper electrodes using N,N'-ethylene-phenanthrolinium dibromide as molecular additive. Selectivities up to 70 % for C<sub>≥2</sub> products are observed for more than 40 h without significant change in the surface morphology. Mechanistic studies reveal several roles for the organic additive, including: the formation of cube-like nanostructures by corrosion of the copper surface, the stabilization of these nanostructures during electrocatalysis by formation of a protective organic layer, and the promotion of C<sub>≥2</sub> products.
Discovering Multiple Clustering Solutions: Grouping Objects in Different Views of the Data (2012)

Traditional clustering algorithms identify just a single clustering of the data. Today's complex data, however, allow multiple interpretations leading to several valid groupings hidden in different views of the database. Each of these multiple clustering solutions is valuable and interesting as different perspectives on the same data and several meaningful groupings for each object are given. Especially for high dimensional data, where each object is described by multiple attributes, alternative clusters in different attribute subsets are of major interest. In this tutorial, we describe several real world application scenarios for multiple clustering solutions. We abstract from these scenarios and provide the general challenges in this emerging research area. We describe state-of-the-art paradigms, we highlight specific techniques, and we give an overview of this topic by providing a taxonomy of the existing clustering methods. By focusing on open challenges, we try to attract young researchers for participating in this emerging research field.
Development of Stable Vibrio cholerae O1 Hikojima Type Vaccine Strains Co–Expressing the Inaba and Ogawa Lipopolysaccharide Antigens (2014)

We describe here the development of stable classical and El Tor V. cholerae O1 strains of the Hikojima serotype that co-express the Inaba and Ogawa antigens of O1 lipopolysaccharide (LPS). Mutation of the wbeT gene reduced LPS perosamine methylation and thereby gave only partial transformation into Ogawa LPS on the cell surface. The strains express approximately equal amounts of Inaba- and Ogawa-LPS antigens which are preserved after formalin-inactivation of the bacteria. Oral immunizations of both inbred and outbred mice with formalin-inactivated whole-cell vaccine preparations of these strains elicited strong intestinal IgA anti-LPS as well as serum vibriocidal antibody responses against both Inaba and Ogawa that were fully comparable to the responses induced by the licensed Dukoral vaccine. Passive protection studies in infant mice showed that immune sera raised against either of the novel Hikojima vaccine strains protected baby mice against infection with virulent strains of both serotypes. This study illustrates the power of using genetic manipulation to improve the properties of bacteria strains for use in killed whole-cell vaccines.
Intelligent cloud capacity management (2012)

Cloud computing as a service promises many business benefits. The cost to pay is that it also faces many technique challenges. One of the challenges is to effectively manage cloud capacity in response to the increased demand changes in clouds, as computing customers now can provision and de-provision virtual machines more frequently. This paper studies cloud capacity prediction as a response to the challenge. We propose an integrated solution for intelligent cloud capacity estimation. In this solution, a novel measure is introduced to quantify and guide the prediction process. Then an ensemble method is utilized to predict the future provisioning/de-provisioning demands respectively. The cloud capacity is estimated using the active virtual machines and the future provisioning/de-provisioning demands altogether. Our proposed solution is simple and with low computational cost. The experiments on the IBM Smart Cloud Enterprise trace data shows our solution is effective.
Bulk iron pyrite as a catalyst for the selective hydrogenation of nitroarenes (2017)

Bulk iron pyrite (FeS<sub>2</sub>) functions as an inexpensive, Earth-abundant, off-the-shelf catalyst capable of selectively hydrogenating a broad scope of substituted nitroarenes to their corresponding aniline derivatives using molecular hydrogen.
The measurement of contact angles on circular tubing surfaces using the captive bubble technique (1985)

Circular tubings are used extensively in biomedical implants and devices. It is desirable to determine contact angles on the inner or outer surfaces of such tubing in its final fabricated form. In this study, a technique for the measurement of contact angles on tubing surfaces in an aqueous environment is reported. This has particular applications to biomaterials research, where polymer tubings contact the biologic environment. In this technique, air or octane captive bubble dimensions can be measured, and an underwater contact angle calculated from these dimensions. The validity of the technique was experimentally confirmed using Solution Grade Biomer and NIH standard polyethylene surfaces.
Serum microRNA-122 level correlates with virologic responses to pegylated interferon therapy in chronic hepatitis C (2013)

MicroRNA-122 (miR-122) facilitates hepatitis C virus replication in vitro. Serum miR-122 has been implicated as a biomarker for various liver diseases; however, its role in chronic hepatitis C remains unclear. To address this issue, 126 patients with chronic hepatitis C who completed pegylated IFN plus ribavirin therapy with sustained virologic response (SVR) or nonresponse (NR) were retrospectively included, and their pretreatment clinical profiles and treatment responses were collected. Serum miR-122 was quantified before and during treatment. Another 51 patients in SVR and NR groups were prospectively enrolled for validation. Serum miR-122 was found to be a surrogate for hepatic miR-122 and positively correlated with hepatic necroinflammation. Patients who showed complete early virologic response and SVR had significantly higher pretreatment serum miR-122 levels than those with NR (P = 0.001 and P = 0.008, respectively), especially in subgroups of patients with hepatitis C virus genotype 2 and IL-28B rs8099917 TT genotype. Patients with IL-28B TT genotype had significantly better treatment responses and higher pretreatment serum miR-122 level than those with GT or GG genotypes. Univariate analysis showed that pretreatment body mass index, γ-glutamyl transpeptidase, triglyceride, IL-28B TT genotype, and serum miR-122 are predictors for SVR. Multivariate analysis specifically in IL-28B TT genotype demonstrated that pretreatment serum miR-122 independently predicted SVR. The validation cohort confirmed a significantly greater pretreatment serum miR-122 level in patients with SVR compared with NR (P = 0.025). In conclusion, serum miR-122 may serve as a surrogate of hepatic miR-122, and a higher pretreatment serum miR-122 level can help predict virologic responses to pegylated IFN plus ribavirin therapy.
Graphene-based membranes (2015)

Graphene is a well-known two-dimensional material that exhibits preeminent electrical, mechanical and thermal properties owing to its unique one-atom-thick structure. Graphene and its derivatives (e.g., graphene oxide) have become emerging nano-building blocks for separation membranes featuring distinct laminar structures and tunable physicochemical properties. Extraordinary molecular separation properties for purifying water and gases have been demonstrated by graphene-based membranes, which have attracted a huge surge of interest during the past few years. This tutorial review aims to present the latest groundbreaking advances in both the theoretical and experimental chemical science and engineering of graphene-based membranes, including their design, fabrication and application. Special attention will be given to the progresses in processing graphene and its derivatives into separation membranes with three distinct forms: a porous graphene layer, assembled graphene laminates and graphene-based composites. Moreover, critical views on separation mechanisms within graphene-based membranes will be provided based on discussing the effect of inter-layer nanochannels, defects/pores and functional groups on molecular transport. Furthermore, the separation performance of graphene-based membranes applied in pressure filtration, pervaporation and gas separation will be summarized. This article is expected to provide a compact source of relevant and timely information and will be of great interest to all chemists, physicists, materials scientists, engineers and students entering or already working in the field of graphene-based membranes and functional films.
Ingested Medium-Chain Fatty Acids Are Directly Utilized for the Acyl Modification of Ghrelin (2005)

Ghrelin, an acylated brain and gut peptide, is primarily produced by endocrine cells of the gastric mucosa for secretion into the circulation. The major active form of ghrelin is a 28-amino-acid peptide containing an n-octanoyl modification at serine that is essential for activity. Studies have identified multiple physiological functions for ghrelin, including GH release, appetite stimulation, and metabolic fuel preference. Until now, there has not been any report detailing the mechanism of ghrelin acyl modification. Here we report that ingestion of either medium-chain fatty acids (MCFAs) or medium-chain triacylglycerols (MCTs) increased the stomach concentrations of acylated ghrelin without changing the total (acyl- and des-acyl-) ghrelin amounts. After ingestion of either MCFAs or MCTs, the carbon chain lengths of the acyl groups attached to nascent ghrelin molecules corresponded to that of the ingested MCFAs or MCTs. Ghrelin peptides modified with n-butyryl or n-palmitoyl groups, however, could not be detected after ingestion of the corresponding short-chain or long-chain fatty acids, respectively. Moreover, n-heptanoyl ghrelin, an unnatural form of ghrelin, could be detected in the stomach of mice after ingestion of either n-heptanoic acid or glyceryl triheptanoate. These findings indicate that ingested medium-chain fatty acids are directly used for the acylation of ghrelin.