gebhart/patrepeval huggingface dataset:
The current landscape of Agent Communication Languages (1999)

Despite the substantial number of multi-agent systems that use an Agent Communication Language (ACL) the dust has not settled yet over the landscape of ACLs. The semantic specification issues have monopolized the debate at the expense of other important pragmatic issues that must be adequately resolved in the immediate future if ACLs are going to support the development of robust agent systems. After introducing some of the basic concepts relating to Agent Communication Languages, we cover KQML and FIPA ACL, the two existing fully-specified ACLs. We give a brief introduction to their semantics and the issues relating to semantic descriptions of ACLs. We then shift our focus beyond the semantics and point to problems and limitations shared by both ACLs. Questions such as the nature of conformance of an agent system with an ACL specification and issues such as naming, registration, authentication, basic facilitation services, etc., may or may not be (technically speaking) part of an ACL ...
START: an automated tool for serial analysis of chromatin occupancy data (2006)

SUPPLEMENTARY INFORMATION is available at http://bio.chip.org/doc/start/START-supplementary.pdf
A Novel Magnetic Harmonic Gear (2009)

Magnetic gears offer several advantages compared to mechanical gears in terms of reduced maintenance, improved reliability, and inherent overload protection while having a high efficiency. This paper describes the principle of operation of a novel form of magnetic gear, which is particularly suited to applications for which a high gear ratio is required. The performance capability of such a magnetic gear is investigated, and it is shown that it transmits a ripple-free torque and that an active torque density of up to 150 kN · m/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> per stage can be achieved when high-energy permanent magnets are employed. Simulation results on this novel gear are verified by experimental measurements on a prototype.
Discovery of protective <scp>B</scp>‐cell epitopes for development of antimicrobial vaccines and antibody therapeutics (2013)

Protective antibodies play an essential role in immunity to infection by neutralizing microbes or their toxins and recruiting microbicidal effector functions. Identification of the protective B-cell epitopes, those parts of microbial antigens that contact the variable regions of the protective antibodies, can lead to development of antibody therapeutics, guide vaccine design, enable assessment of protective antibody responses in infected or vaccinated individuals, and uncover or localize pathogenic microbial functions that could be targeted by novel antimicrobials. Monoclonal antibodies are required to link in vivo or in vitro protective effects to specific epitopes and may be obtained from experimental animals or from humans, and their binding can be localized to specific regions of antigens by immunochemical assays. The epitopes are then identified with mapping methods such as X-ray crystallography of antigen-antibody complexes, antibody inhibition of hydrogen-deuterium exchange in the antigen, antibody-induced alteration of the nuclear magnetic resonance spectrum of the antigen, and experimentally validated computational docking of antigen-antibody complexes. The diversity in shape, size and structure of protective B-cell epitopes, and the increasing importance of protective B-cell epitope discovery to development of vaccines and antibody therapeutics are illustrated through examples from different microbe categories, with emphasis on epitopes targeted by broadly neutralizing antibodies to pathogens of high antigenic variation. Examples include the V-shaped Ab52 glycan epitope in the O-antigen of Francisella tularensis, the concave CR6261 peptidic epitope in the haemagglutinin stem of influenza virus H1N1, and the convex/concave PG16 glycopeptidic epitope in the gp120 V1/V2 loop of HIV type 1.
A pseudo-outbreak of salmonellosis (1995)

during July 1991, a single laboratory reported an increased number of an unusual salmonella isolate. An outbreak control team was convened. A case was defined as an individual with diarrhoea from whose faecal sample Salmonella hadar was isolated after 1 July 1991. By 30 July, 90 isolates had been identified and 57 persons interviewed including 39 primary cases. Interviews failed to identify any common features among the cases. A review of the laboratory procedures revealed that the selenite enrichment medium was inoculated using the spoon from the stool collection kit after it was used to emulsify the faecal sample with saline for microscopy. Salmonella hadar was isolated from this saline. Once this practice was stopped, no further isolates of S. hadar were made. This pseudo-outbreak is a powerful reminder to verify the existence of an outbreak, especially when epidemiological data are inconsistent.
Club Car competitive cost analysis (2005)

There are major differences between the commercial and consumer markets. Commercial markets cater to industry while consumer markets focus on everyday customers who are interested in satisfying their own needs. Contrast to the John Deere Gator CX, the Club Car Carryall 1 focuses on the industrial market and is designed for a robust environment. Club Car's key goal is to enter the consumer market, and this article aims at defining how teardown analysis, cost analysis, and value engineering were used to implement an innovative and cost effective design that will yield a tangible product that Club Car can incorporate in its future production line. A culmination of 650 man-hours, and an estimated budget of $12,800, have resulted in a redesigned vehicle that satisfies the scope. The Club Car Carryall 1 now caters directly to the consumer market, while maintaining a competitive edge with the current market leader John Deere.
The Citrate Transport System of <i>Lactococcus lactis</i> subsp. <i>lactis</i> biovar diacetylactis Is Induced by Acid Stress (1998)

ABSTRACT Citrate transport in Lactococcus lactis subsp. lactis biovar diacetylactis is catalyzed by citrate permease P (CitP), which is encoded by the plasmidic citP gene. We have shown previously that citP is included in the citQRP operon, which is mainly transcribed from the P1 promoter in L. lactis subsp. lactis biovar diacetylactis. Furthermore, transcription of citQRP and citrate transport are not induced by the presence of citrate in the growth medium. In this work, we analyzed the influence of the extracellular pH on the expression of citP . The citrate transport system is induced by natural acidification of the medium during cell growth and by a shift to media buffered at acidic pHs. This inducible response to acid stress takes place at the transcriptional level and seems to be due to increased utilization of the P1 promoter. Increased transcription correlates with increased synthesis of CitP and results in higher citrate transport activity catalyzed by the cells. Finally, this acid stress response seems to provide L. lactis subsp. lactis biovar diacetylactis with a selective advantage resulting from cometabolism of glucose and citrate at low pHs.
Myasthenia gravis: diagnostic and management dilemmas (2001)

This review focuses on the diagnostic tests that may help to confirm myasthenia in patients without acetylcholine receptor antibodies, including the newly discovered anti-muscle-specific receptor tyrosine kinase antibody and other investigations. We discuss management dilemmas, particularly those that revolve around treatments whose efficacy is questionable or unproved, such as thymectomy. We review the important issue of how treatments are assessed, and examine future treatment trial designs.
Mechanisms of IL-12 Synthesis by Human Dendritic Cells Treated with the Chemical Sensitizer NiSO4 (2010)

Allergic contact dermatitis, caused by metallic ions, is a T cell-mediated inflammatory skin disease. IL-12 is a 70-kDa heterodimeric protein composed of IL-12p40 and IL-12p35, playing a major role in the generation of allergen-specific T cell responses. Dendritic cells (DCs) are APCs involved in the induction of primary immune responses, as they possess the ability to stimulate naive T cells. In this study, we address the question whether the sensitizer nickel sulfate (NiSO(4)) itself or in synergy with other signals can induce the secretion of IL-12p70 in human monocyte-derived DCs (Mo-DCs). We found that IL-12p40 was produced by Mo-DC in response to NiSO(4) stimulation. Addition of IFN-gamma concomitantly to NiSO(4) leads to IL-12p70 synthesis. NiSO(4) treatment leads to the activation of MAPK, NF-kappaB pathways, and IFN regulatory factor 1 (IRF-1). We investigated the role of these signaling pathways in IL-12 production using known pharmacological inhibitors of MAPK and NF-kappaB pathways and RNA interference-mediated silencing of IRF-1. Our results showed that p38 MAPK, NF-kappaB, and IRF-1 were involved in IL-12p40 production induced by NiSO(4). Moreover, IRF-1 silencing nearly totally abrogated IL-12p40 and IL-12p70 production provoked by NiSO(4) and IFN-gamma. In response to NiSO(4), we observed that STAT-1 was phosphorylated on both serine and tyrosine residues and participated to NiSO(4)-induced IRF-1 activation. N-acetylcysteine abolished STAT-1 phosphorylation, suggesting that STAT-1 activation may be dependent on NiSO(4)-induced alteration of the redox status of the cell. These results indicate that p38 MAPK, NF-kappaB, and IRF-1 are activated by NiSO(4) in Mo-DC and cooperate for IL-12 production.
First demonstration of InAlAs/InGaAs HEMTs using T-gates fabricated by a bilayer of UVIII and PMMA resists (2002)

We report the first lattice matched InP HEMTs fabricated using a T-gate process based on a bilayer of Shipley UVIII DUV resist and PMMA. A DC gate resistance of 220 /spl Omega//mm was achieved, leading to f/sub T/ of 193 GHz and Maximum Available Gain (MAG) values of 13 dB at 94 GHz for 100 /spl mu/m wide devices.
Negative Regulation of T Cell Activation by Placental Protein 14 Is Mediated by the Tyrosine Phosphatase Receptor CD45 (2003)

CD45 is the major protein tyrosine phosphatase receptor on T cell surfaces that functions as both a positive and a negative regulator of T cell receptor (TCR) signaling. Although CD45 is required for the activation of TCR-associated Src family kinases, it also dephosphorylates phosphoproteins involved in the TCR-signaling cascade. This study links CD45 to the inhibitory activity of placental protein 14 (PP14), a major soluble protein of pregnancy that is now known to be a direct modulator of T cells and to function by desensitizing TCR signaling. PP14 and CD45 co-capped with each other, pointing to a physical linkage between the two. Interestingly, however, the binding of PP14 to T cell surfaces was not restricted to CD45 alone, with evidence showing that PP14 binds to other surface molecules in a carbohydrate-dependent fashion. Notwithstanding the broader molecular binding potential of PP14, its interaction with CD45 appeared to have special functional significance. Using transfected derivatives of the HPB. ALL mutant T cell line that differ in CD45 expression, we established that the inhibitory effects of PP14 are dependent upon the expression of intact CD45 on T cell surfaces. Based upon these findings, we propose a new immunoregulatory model for PP14, wherein one of its surface molecular targets, CD45, mediates its T cell inhibitory activity, accounting for the intriguing capacity of PP14 to elevate TCR activation thresholds and thereby down-regulate T cell activation.
Thiotungstate isopolyanions: an electrometric study (1981)

The stoichiometry of the various polyanions formed during the reaction between sodium thiotungstate and sulphuric acid has been investigated by pH and conductance measurements, which have revealed the formation of different polymerized species, viz. (W 4 S I5 ) 6− , (W 2 S 7 ) 2− , and possibly (W 4 S 13 ) 2− in the vicinity of pH 6.2, 4.4, and 2.7 respectively. The formation of (W 4 S 13 ) 2− is, however, not evidenced by the pH investigations. It was observed that at higher hydrogen ion concentration (pH < 2.4), thiotungstate decomposes into hydrated tungsten trisulphide.
Microplastics research—from sink to source (2018)

Microplastics are ubiquitous not just in the ocean but also on land and in freshwater systems
Singularity free algorithm for molecular dynamics simulation of rigid polyatomics (1977)

Using a transformation of the rigid body equations of motion due to Evans [4], a new algorithm is presented for the molecular dynamics simulation of rigid polyatomic molecules. The algorithm consists of solving the eulerian rigid body equations, using quaternions to represent orientations, by a fifth-order predictor corrector method. Compared to previous methods, it is shown that this algorithm leads to an order of magnitude increase in computing speed.
Breastfeeding promotion and priority setting in health (1996)

An increase in exclusive breastfeeding prevalence can substantially reduce mortality and morbidity among infants. In this paper, estimates of the costs and impacts of three breastfeeding promotion programmes, implemented through maternity services in Brazil, Honduras and Mexico, are used to develop cost-effectiveness measures and these are compared with other health interventions. The results show that breastfeeding promotion can be one of the most cost-effective health interventions for preventing cases of diarrhoea, preventing deaths from diarrhoea, and gaining disability-adjusted life years (DALYs). The benefits are substantial over a broad range of programme types. Programmes starting with the removal of formula and medications during delivery are likely to derive a high level of impact per unit of net incremental cost. Cost-effectiveness is lower (but still attractive relative to other interventions) if hospitals already have rooming-in and no bottle-feeds; and the cost-effectiveness improves as programmes become well-established. At an annual cost of about 30 to 40 US cents per birth, programmes starting with formula feeding in nurseries and maternity wards can reduce diarrhoea cases for approximately $0.65 to $1.10 per case prevented, diarrhoea deaths for $100 to $200 per death averted, and reduce the burden of disease for approximately $2 to $4 per DALY. Maternity services that have already eliminated formula can, by investing from $2 to $3 per birth, prevent diarrhoea cases and deaths for $3.50 to $6.75 per case, and $550 to $800 per death respectively, with DALYs gained at $12 to $19 each.
Unsupervised Fluorescence Lifetime Imaging Microscopy for High Content and High Throughput Screening (2007)

Proteomics and cellomics clearly benefit from the molecular insights in cellular biochemical events that can be obtained by advanced quantitative microscopy techniques like fluorescence lifetime imaging microscopy and Förster resonance energy transfer imaging. The spectroscopic information detected at the molecular level can be combined with cellular morphological estimators, the analysis of cellular localization, and the identification of molecular or cellular subpopulations. This allows the creation of powerful assays to gain a detailed understanding of the molecular mechanisms underlying spatiotemporal cellular responses to chemical and physical stimuli. This work demonstrates that the high content offered by these techniques can be combined with the high throughput levels offered by automation of a fluorescence lifetime imaging microscope setup capable of unsupervised operation and image analysis. Systems and software dedicated to image cytometry for analysis and sorting represent important emerging tools for the field of proteomics, interactomics, and cellomics. These techniques could soon become readily available both to academia and the drug screening community by the application of new all-solid-state technologies that may results in cost-effective turnkey systems. Here the application of this screening technique to the investigation of intracellular ubiquitination levels of alpha-synuclein and its familial mutations that are causative for Parkinson disease is shown. The finding of statistically lower ubiquitination of the mutant alpha-synuclein forms supports a role for this modification in the mechanism of pathological protein aggregation.
Video processing for panoramic streaming using HEVC and its scalable extensions (2016)

Panoramic streaming is a particular way of video streaming where an arbitrary Region-of-Interest (RoI) is transmitted from a high-spatial resolution video, i.e. a video covering a very “wide-angle” (much larger than the human field-of-view – e.g. 360°). Some transport schemes for panoramic video delivery have been proposed and demonstrated within the past decade, which allow users to navigate interactively within the high-resolution videos. With the recent advances of head mounted displays, consumers may soon have immersive and sufficiently convenient end devices at reach, which could lead to an increasing demand for panoramic video experiences. The solution proposed within this paper is built upon tile-based panoramic streaming, where users receive a set of tiles that match their RoI, and consists in a low-complexity compressed domain video processing technique for using H.265/HEVC and its scalable extensions (H.265/SHVC and H.265/MV-HEVC). The proposed technique generates a single video bitstream out of the selected tiles so that a single hardware decoder can be used. It overcomes the scalability issue of previous solutions not using tiles and the battery consumption issue inherent of tile-based panorama streaming, where multiple parallel software decoders are used. In addition, the described technique is capable of reducing peak streaming bitrate during changes of the RoI, which is crucial for allowing a truly immersive and low latency video experience. Besides, it makes it possible to use Open GOP structures without incurring any playback interruption at switching events, which provides a better compression efficiency compared to closed GOP structures.
Overview of the wikipedia retrieval task at ImageCLEF 2010 (2010)

ImageCLEF's Wikipedia Retrieval task provides a testbed for the system-oriented evaluation of multimedia information retrieval from a collection of Wikipedia images. The aim is to investigate retrieval approaches in the context of a large and heterogeneous collection of images (similar to those encountered on the Web) that are searched for by users with diverse information needs. This paper presents an overview of the resources, topics, and assessments of the Wikipedia Retrieval task at ImageCLEF 2010, summarizes the retrieval approaches employed by the participating groups, and provides an analysis of the main evaluation results.
Influence of Surfactant Concentration and Background Salt on Forced Dynamic Wetting and Dewetting (2011)

Forced wetting and dewetting of polymer surfaces in aqueous solutions containing cationic surfactant cetyltrimethylammonium bromide (CTAB) has been studied with a rotating cylinder half immersed in the solution. The receding contact angle decreases with faster withdrawing speeds. This decrease is enhanced when adding CTAB. The addition of salt to the CTAB solution further enhances the effect but does not have a significant effect alone. We interpret this change in the dynamic contact angle with a surfactant-induced Marangoni effect.
Occurrence and neuroendocrine role of <scp>D</scp>‐aspartic acid and <i>N</i>‐methyl‐<scp>D</scp>‐aspartic acid in <i>Ciona intestinalis</i> (2003)

Probes for the occurrence of endogenous D-aspartic acid (D-Asp) and N-methyl-D-aspartic acid (NMDA) in the neural complex and gonads of a protochordate, the ascidian Ciona intestinalis, have confirmed the presence of these two excitatory amino acids and their involvement in hormonal activity. A hormonal pathway similar to that which occurs in vertebrates has been discovered. In the cerebral ganglion D-Asp is synthesized from L-Asp by an aspartate racemase. Then, D-Asp is transferred through the blood stream into the neural gland where it gives rise to NMDA by means of an NMDA synthase. NMDA, in turn, passes from the neuronal gland into the gonads where it induces the synthesis and release of a gonadotropin-releasing hormone (GnRH). The GnRH in turn modulates the release and synthesis of testosterone and progesterone in the gonads, which are implicated in reproduction.
Liver Tumor Segmentation in CT Scans Using Modified SegNet (2020)

The main cause of death related to cancer worldwide is from hepatic cancer. Detection of hepatic cancer early using computed tomography (CT) could prevent millions of patients' death every year. However, reading hundreds or even tens of those CT scans is an enormous burden for radiologists. Therefore, there is an immediate need is to read, detect, and evaluate CT scans automatically, quickly, and accurately. However, liver segmentation and extraction from the CT scans is a bottleneck for any system, and is still a challenging problem. In this work, a deep learning-based technique that was proposed for semantic pixel-wise classification of road scenes is adopted and modified to fit liver CT segmentation and classification. The architecture of the deep convolutional encoder-decoder is named SegNet, and consists of a hierarchical correspondence of encode-decoder layers. The proposed architecture was tested on a standard dataset for liver CT scans and achieved tumor accuracy of up to 99.9% in the training phase.
Gas-Responsive Polymers (2017)

Gas-responsive polymers have inspired much interest over the past ten years. Gas triggers can interact with functionalities on polymer chains and, thus, modulate their chain structures, architectures, and aggregation states. This review summarizes the latest research progresses in the theme of developing different gas triggers for fine control over some critical properties of polymers, as well as their potential applications in various areas. We focus on the interactions/reactions between gases and gas-responsive functionalities of polymers and highlight some state-of-art developments, which provided good insight and understanding of each particular gas-responsive polymer. We also offer a perspective point of view on future research directions on gas-responsive polymers, both in fundamental studies and in potential application developments.
Report on the Perkin Journals for 1991 (1992)

S. M. Roberts and S. R. Buxton, J. Chem. Soc., Perkin Trans. 2, 1992, vb DOI: 10.1039/P299200000VB
Variable inhibition of placental IgG transfer <i>in vitro</i> with commercial IVgG preparations (1999)

Maternal administration of high-dose intravenous immunoglobulin (IVIgG) for treating fetal RhD haemolytic disease and alloimmune thrombocytopenias may be beneficial. Treatment failures, even when IVIgG is used optimally, may result from product differences. Using an in vitro placental perfusion model there was significant inhibition of placental anti-D IgG transfer with three commercial IVIgG preparations where circulating maternal IgG concentrations were > 20 g/l. One IVIgG product, which was not inhibitory, had lower circulating IgG levels (16.5 +/- 0.9 g/l) and significantly reduced placental transfer of total IgG, suggesting that the reduced functional activity of IgG from IVIgG preparations may correlate with poor clinical efficacy.