gebhart/patrepeval huggingface dataset:
The raman laser system for Mach-Zehnder atom interferometry (2016)

We produced two Raman-laser beams with a frequency offset of 6.834GHz by injection-locking of a master diode-laser to a slave diode-laser. The master laser was phase-modulated at 6.834 GHz with an Electro-Optic Modulator and then injected into the slave laser that was oscillating around one of the side-bands. The relative linewidth of the two lasers was less than 1 Hz. Utilizing these laser beams, we realized the coherent manipulation of atomic wave packets in a Mach-Zehnder type atom interferometry.
Testing and evaluation of an integrated GPS/INS system for small AUV navigation (1999)

A Small Autonomous Underwater Vehicle Navigation System (SANS) is being developed at the Naval Postgraduate School. The SANS is an integrated Global Positioning System/Inertial Navigation System (GPS/INS) navigation system composed of low-cost and small-size components. It is designed to demonstrate the feasibility of using a low-cost strap-down inertial measurement unit (IMU) to navigate between intermittent GPS fixes. The present hardware consists of a GPS/DGPS receiver, IMU, compass, water speed sensor, water depth sensor, and a data processing computer. The software is based on a 12-state complementary filter that combines measurement data from all sensors to derive a vehicle position/orientation estimate. This paper describes hardware and software design and testing results of the SANS. It is shown that results from tilt table testing and bench testing provide an effective means for tuning filter gains. Ground vehicle testing verifies the overall functioning of the SANS and exhibits an encouraging degree of accuracy.
Rapid Identification of Penicillin and Macrolide Resistance Genes and Simultaneous Quantification of <i>Streptococcus pneumoniae</i> in Purulent Sputum Samples by Use of a Novel Real-Time Multiplex PCR Assay (2008)

We evaluated a real-time quantitative PCR combined with a multiplex PCR assay for the quantification of Streptococcus pneumoniae and the simultaneous detection of drug-resistant genes by gel-based PCR, using purulent sputum samples. This assay correctly quantified S. pneumoniae and identified their penicillin and erythromycin susceptibilities directly from samples within 3 h.
Structure‐Affinity Binding Relationships by Principal‐Component‐Regression Analysis of Anthraquinone Dyes (1995)

Abstract Dye‐fibre binding was modelled by principal‐component‐regression analysis (PCRA) method for two series of 46, respectively 49 anthraquinone vat dyes. Robust equations with predictive modelling power were proposed for the correlations with structural parameters (r 2 = 0.92 and s = 0.48, respectively r 2 = 0.94 and s = 0.47). They indicated the presence of steric, electronic and hydrophobic effects in the dyeing process. PCRA allows to avoid the multicollinearity of the physicochemical descriptors, yielding better results as compared to those obtained from ordinary leastsquares analysis.
Relative Intensity Correction of Raman Spectrometers: NIST SRMs 2241 through 2243 for 785 nm, 532 nm, and 488 nm/514.5 nm Excitation (2007)

Standard Reference Materials SRMs 2241 through 2243 are certified spectroscopic standards intended for the correction of the relative intensity of Raman spectra obtained with instruments employing laser excitation wavelengths of 785 nm, 532 nm, or 488 nm/514.5 nm. These SRMs each consist of an optical glass that emits a broadband luminescence spectrum when illuminated with the Raman excitation laser. The shape of the luminescence spectrum is described by a polynomial expression that relates the relative spectral intensity to the Raman shift with units in wavenumber (cm(-1)). This polynomial, together with a measurement of the luminescence spectrum of the standard, can be used to determine the spectral intensity-response correction, which is unique to each Raman system. The resulting instrument intensity-response correction may then be used to obtain Raman spectra that are corrected for a number of, but not all, instrument-dependent artifacts. Peak area ratios of the intensity-corrected Raman spectrum of cyclohexane are presented as an example of a methodology to validate the spectral intensity calibration process and to illustrate variations that can occur in this measurement.
Field Dependence of Magnetoresistance in No-binder Soft Carbons at 77°K (1971)

The dependence of magnetoresistance on magnetic field is investigated at 77°K for soft carbons prepared from Texas petroleum coke (no-binder) by heat treatments in the range 1400°–3000°C. For specimens heat treated at temperatures between 1400° and 2200°C, the magnetoresistance is negative; its absolute value increases monotonically with increasing heat treatment temperature (HTT) and with increasing magnetic field. For specimens heat treated between 2400° and 2450°C, the magnetoresistance is negative and tends to saturate at higher fields. The absolute value becomes larger for lower HTT. Specimens heat treated between 2400° and 2450°C show a magnetoresistance which is negative at low fields, passes through minimum and becomes greater for lower HTT. For specimens with HTT≥2570°C, no negative magnetoresistance is observed even at low fields. Some discussion of the effects found is included.
Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It (2020)

Antimicrobial resistance represents an enormous global health crisis and one of the most serious threats humans face today. Some bacterial strains have acquired resistance to nearly all antibiotics. Therefore, new antibacterial agents are crucially needed to overcome resistant bacteria. In 2017, the World Health Organization (WHO) has published a list of antibiotic-resistant priority pathogens, pathogens which present a great threat to humans and to which new antibiotics are urgently needed the list is categorized according to the urgency of need for new antibiotics as critical, high, and medium priority, in order to guide and promote research and development of new antibiotics. The majority of the WHO list is Gram-negative bacterial pathogens. Due to their distinctive structure, Gram-negative bacteria are more resistant than Gram-positive bacteria, and cause significant morbidity and mortality worldwide. Several strategies have been reported to fight and control resistant Gram-negative bacteria, like the development of antimicrobial auxiliary agents, structural modification of existing antibiotics, and research into and the study of chemical structures with new mechanisms of action and novel targets that resistant bacteria are sensitive to. Research efforts have been made to meet the urgent need for new treatments; some have succeeded to yield activity against resistant Gram-negative bacteria by deactivating the mechanism of resistance, like the action of the β-lactamase Inhibitor antibiotic adjuvants. Another promising trend was by referring to nature to develop naturally derived agents with antibacterial activity on novel targets, agents such as bacteriophages, DCAP(2-((3-(3,6-dichloro-9<i>H</i>-carbazol-9-yl)-2-hydroxypropyl)amino)-2(hydroxymethyl)propane1,3-diol, Odilorhabdins (ODLs), peptidic benzimidazoles, quorum sensing (QS) inhibitors, and metal-based antibacterial agents.
[Bone hyperresorption in bone metastases]. (2000)

MECHANISMS OF BONE LOSS: In patients with bone metastases, bone loss is the consequence of a dissociated process combining excessive bone resorption and inhibited bone formation. This destructive process occurs in response to soluble factors secreted by metastatic cells (PTH-rP, cytokines) which activate osteoclasts. These cells also secrete proteases (cathepsin K, metalloprotease MMP-9) which degrade the bone's collagen network. Excessive bone resorption is also favored by direct interaction between the metastatic cells and stromal cells in the bone marrow in response to the activation of membrane receptors (integrins a4 beta 1 and a4 beta 7). Finally, metastatic cells secrete non-identified soluble factors capable of inhibiting osteoblast proliferation in vitro. EFFECT OF BONE LOSS ON THE METASTASIS: Bone is a major reservoir of growth factors (mainly TGF beta and IGF-1). Positive feedback mechanism operates at the site of osteolysis where TGF beta released by bone tissue induces a paracrine stimulation of PTH-rP production by metastatic cells. IGF-1 released by the bone favors grow of metastatic cells present in the marrow. In addition, IGF-1 as well as collagen proteolytic fragments may stimulate recruitment of new metastatic cells at the site of the bone metastasis. This creates a vicious circle of mutual stimulation between bone destruction and tumor proliferation.
Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity (2015)

Advances in protein therapy are hindered by the poor stability, inadequate pharmacokinetic (PK) profiles, and immunogenicity of many therapeutic proteins. Polyethylene glycol conjugation (PEGylation) is the most successful strategy to date to overcome these shortcomings, and more than 10 PEGylated proteins have been brought to market. However, anti-PEG antibodies induced by treatment raise serious concerns about the future of PEGylated therapeutics. Here, we demonstrate a zwitterionic polymer network encapsulation technology that effectively enhances protein stability and PK while mitigating the immune response. Uricase modified with a comprehensive zwitterionic polycarboxybetaine (PCB) network exhibited exceptional stability and a greatly prolonged circulation half-life. More importantly, the PK behavior was unchanged, and neither anti-uricase nor anti-PCB antibodies were detected after three weekly injections in a rat model. This technology is applicable to a variety of proteins and unlocks the possibility of adopting highly immunogenic proteins for therapeutic or protective applications.
An algorithm for the medial axis transform of 3D polyhedral solids (1996)

The medial axis transform (MAT) is a representation of an object which has been shown to be useful in design, interrogation, animation, finite element mesh generation, performance analysis, manufacturing simulation, path planning and tolerance specification. In this paper, an algorithm for determining the MAT is developed for general 3D polyhedral solids of arbitrary genus without cavities, with nonconvex vertices and edges. The algorithm is based on a classification scheme which relates different pieces of the medial axis (MA) to one another, even in the presence of degenerate MA points. Vertices of the MA are connected to one another by tracing along adjacent edges, and finally the faces of the axis are found by traversing closed loops of vertices and edges. Representation of the MA and its associated radius function is addressed, and pseudocode for the algorithm is given along with recommended optimizations. A connectivity theorem is proven to show the completeness of the algorithm. Complexity estimates and stability analysis for the algorithms are presented. Finally, examples illustrate the computational properties of the algorithm for convex and nonconvex 3D polyhedral solids with polyhedral holes.
The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: a systematic review (2018)

Despite the heterogeneity of studies regarding oxaliplatin starting dose, drug regimen, neuropathy assessment tools and study design, a large number of patients developed acute neuropathy. To develop a better preventive and therapeutic guideline for acute/chronic neuropathy, a prospective study should be conducted in a large cohort of patients in relation to drug regimen, starting/ranges (minimal) of doses producing acute neuropathy, treatment compliance, patient and clinical risk factors using a standardised neuropathy assessment tool.
Joint calibration of 3D resist image and CDSEM (2013)

Traditionally, an optical proximity correction model is to evaluate the resist image at a specific depth within the photoresist and then extract the resist contours from the image. Calibration is generally implemented by comparing resist contours with the critical dimensions (CD). The wafer CD is usually collected by a scanning electron microscope (SEM), which evaluates the CD based on some criterion that is a function of gray level, differential signal, threshold or other parameters set by the SEM. However, the criterion does not reveal which depth the CD is obtained at. This depth inconsistency between modeling and SEM makes the model calibration difficult for low <i>k<sub>1</sub></i> images. In this paper, the vertical resist profile is obtained by modifying the model from planar (2D) to quasi-3D approach and comparing the CD from this new model with SEM CD. For this quasi-3D model, the photoresist diffusion along the depth of the resist is considered and the 3D photoresist contours are evaluated. The performance of this new model is studied and is better than the 2D model.
Specific Inhibition of Tumor Cells by Oncogenic EGFR Specific Silencing by RNA interference (2013)

Anticancer agents that have minimal effects on normal cells and tissues are ideal cancer drugs. Here, we show specific inhibition of human cancer cells carrying oncogenic mutations in the epidermal growth factor receptor (EGFR) gene by means of oncogenic allele-specific RNA interference (RNAi), both in vivo and in vitro. The allele-specific RNAi (ASP-RNAi) treatment did not affect normal cells or tissues that had no target oncogenic allele, whereas the suppression of a normal EGFR allele by a conventional in vivo RNAi caused adverse effects, i.e., normal EGFR is vital. Taken together, our current findings suggest that specific inhibition of oncogenic EGFR alleles without affecting the normal EGFR allele may provide a safe treatment approach for cancer patients and that ASP-RNAi treatment may be capable of becoming a safe and effective, anticancer treatment method.
<title>High-pressure gas-scintillation-proportional counter for the focus of a hard-x-ray telescope</title> (1999)

We are developing a high-pressure Gas Scintillation Proportional Counter for the focus of a balloon-borne hard - x-ray telescope. The device has a total active diameter of 50 mm, of which the central 20 mm only is used, and is filled with xenon + 4 percent helium at a total pressure of 10<SUP>6</SUP> Pa giving a quantum efficiency of greater than 85 percent up to 60 keV. The detector entrance is sealed with a beryllium window, 3-mm thick, which provides useful transmission down to 6 keV, well below the atmospheric cut- off at balloon float altitudes. Scintillation light exits the detector via a UV transmitting window in its base and is registered by a Hamamatsu position-sensitive crossed-grid- readout photomultiplier tube. Initial testing is underway and preliminary measurements of light yield, energy resolution and spatial resolution will be reported. Simulations show that a spatial resolution of 0.5 mm FWHM or better should be achievable up to 60 keV, and this is well matched to the angular resolution and plate scale of the mirror system. The energy resolution has been measured to be around 5 percent at 22 keV. Full details of the instrument design and its performance will be presented. A first flight is scheduled for the Fall of 99, on a stratospheric balloon to be launched form Fort Sumner, New Mexico.
ChemInform Abstract: β‐NaMnO<sub>2</sub>: A High‐Performance Cathode for Sodium‐Ion Batteries. (2015)

Abstract β‐NaMnO 2 is prepared by firing of Na 2 CO 3 (15 wt.% excess) and Mn 2 O 3 in O 2 (2 x 950 °C, 1 d, heating rates of 1 and 5 °C/min).
FIB-SEM and TEMT Observation of Highly Elastic Rubbery Material with Nanomatrix Structure (2008)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTFIB-SEM and TEMT Observation of Highly Elastic Rubbery Material with Nanomatrix StructureSeiichi Kawahara*†, Yoshimasa Yamamoto†, Shuji Fujii†, Yoshinobu Isono†, Ken-ichi Niihara‡, Hiroshi Jinnai‡, Hideo Nishioka§, and Akio Takaoka∥View Author Information Department of Materials Science and Technology, Faculty of Engineering, Nagaoka University of Technology, Nagaoka, Niigata 940-2188, Japan, Department of Macromolecular Science and Engineering, Graduate School of Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-8585, Japan, JEOL Ltd., 1-2-3 Musashino, Akishima, Tokyo 196-8556, Japan, and Research Center for Ultra-High Voltage Electron Microscopy, Osaka University, 7-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan* To whom correspondence should be addressed at the Department of Materials Science and Technology, Faculty of Engineering, Nagaoka University of Technology, Nagaoka, Niigata 940-2188, Japan. Telephone: 81-258-47-9301 . Fax:81-258-47-9300. E-mail: [email protected]†Department of Materials Science and Technology, Faculty of Engineering, Nagaoka University of Technology.‡Department of Macromolecular Science and Engineering, Graduate School of Science and Engineering, Kyoto Institute of Technology.§JEOL Ltd.∥Research Center for Ultra-High Voltage Electron Microscopy, Osaka University.Cite this: Macromolecules 2008, 41, 12, 4510–4513Publication Date (Web):May 20, 2008Publication History Received22 December 2007Revised24 March 2008Published online20 May 2008Published inissue 1 June 2008https://pubs.acs.org/doi/10.1021/ma7028538https://doi.org/10.1021/ma7028538brief-reportACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views948Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Biopolymers,Chemical structure,Hydrocarbons,Nanoparticles Get e-Alerts
Effect of Average Particle Size and Distribution on the Performance of Copolymer Polyols (2003)

Copolymer (graft) polyols with varying particle size distribution were evaluated in a typical molded seating foam formulation. Three separate studies were conducted. In the first study, a graft polyol with a wide particle size distribution was fractionated by ultracentrifugation. The second and third studies used narrowly dispersed graft polyols of different average particle size and their blends. For the second study, the average particle sizes for the blend components were 0.26 and 7.6 mm (where the 7.6 mm component contained primarily 9 mm “large” particles). For the third study, they were 0.15, 1.4 and 3.0 mm. A three-component mixture experiment was designed for the third study, and the data was analyzed by model fitting. In the second study, cell opening increased and foam physical properties improved as the fraction of small particles in the bimodal blend increased. For the three-component mixture study, we report optimal blend compositions for cell opening, selected mechanical properties and flammability performance (MVSS302z). Optical microscopy of the foam cell structure and dynamic mechanical analysis (DMA) were conducted in order to explain the above results in terms of the interaction of the copolymer particles with the foam cell structure and polyurethane-urea matrix.
Optimization of a conical antenna for pulse radiation: an efficient design using resistive loading (1993)

The conical monopole antenna with a section of continuous resistive loading is considered as a radiator for temporally short, broad-bandwidth pulses. The geometrical details of the coaxial feed and the resistive loading are varied to optimize this structure for pulse radiation. Compared with the perfectly conducting cone, the optimized resistive cone radiates a better reproduction of the pulse excitation with no loss in amplitude, and has internal reflections that are much smaller in amplitude. Graphical displays of the field surrounding the antenna are used to give insight into the physical processes for transient radiation from this antenna. Experimental models were constructed to verify the optimization and demonstrate the practicality of the design. Measurements of both the reflected voltage in the feed line and the time-varying radiated field are in excellent agreement with the theoretical calculations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Analyse des Orientierungszustandes zweiachsig gereckter Polyäthylenterephthalat-Folien (2008)

ZusammenfassungAusgehend von einem pseudo-affinen Deformationsmodell werden Ausdrücke hergeleitet, die den Orientierungszustand entsprechender Strukturen mit den Reckgraden auch bei nicht-orthogonalen Reckverhältnissen verknüpfen. Es wird angenommen, daß die Differenz zwischen experimentell gemessenen Orientierungsgraden und den aufgrund der Reckverhältnisse zu erwartenden dem viskosen Anteil an der Verformung zuzuschreiben ist. Auf dieser Basis wird das Phänomen des „Bowing“ einer Polyäthylenterephthalat-Folie hinsichtlich elastischer und viskoser Verformung sowie des Spannungsverlaufs über den Folienquerschnitt analysiert.
A 200dB Dynamic Range Iris-less CMOS Image Sensor with Lateral Overflow Integration Capacitor using Hybrid Voltage and Current Readout Operation (2006)

A 2.6 X 2.6mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> image sensor fabricated in 0.35μm 2P3M CMOS contains 64 X 64 pixels with 20 X 20μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> pixel size and has an extended dynamic range of over 200dB. This DR is equivalent to the incident light ranging from about 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> lx with the lens iris fixed
Electrochemical Reduction for trans-Complexes of Cobalt (III) with Bis(ethylenediamine) and Monodendate Ligands (1989)

Electrochemical reductions of (where X is cyanide, nitrite, ammonia, and isothiocyanate) were investigated by cyclic voltammetry and polarography at mercury and glassy carbon electrode. was reduced to Co(II) complex followed by adsorption to the mercury electrode. Cyanide ion was not released from the reduced Co(II) complex but the cyanide and (en) were released after the reduction to metallic cobalt. The other complexes except were reduced to cobalt(II) complexes followed by release of monodendate ligand, and (en) was released at the reduction step to metallic cobalt. was reduced to cobalt(Ⅱ) complex, and ion was released followed by electroreduction through ECE mechanism at pH 2. On glassy carbon electrode, all complexes of Co(III) were reduced to Co(II) complexes with irreversible one-electron diffusion controlled reaction in which (en) was not released at this step. Increasing absorption wave number of complexes caused to negative shift of peak potential.