gebhart/patrepeval huggingface dataset:
Laser stabilization at 1536 nm using regenerative spectral hole burning (2001)

Laser frequency stabilization giving a 500-Hz Allan deviation for a 2-ms integration time with drift reduced to 7 kHz/min over several minutes was achieved at 1536 nm in the optical communication band. A continuously regenerated spectral hole in the inhomogeneously broadened ${}^{4}{I}_{15/2}{(1)}^{4}{I}_{13/2}(1)$ optical absorption of an ${\mathrm{Er}}^{3+}:{\mathrm{Y}}_{2}{\mathrm{SiO}}_{5}$ crystal was used as the short-term frequency reference, while a variation on the locking technique allowed simultaneous use of the inhomogeneously broadened absorption line as a long-term reference. The reported frequency stability was achieved without vibration isolation. Spectral hole burning frequency stabilization provides ideal laser sources for high-resolution spectroscopy, real-time optical signal processing, and a range of applications requiring ultra-narrow-band light sources or coherent detection; the time scale for stability and the compatibility with spectral hole burning devices make this technique complementary to other frequency references for laser stabilization.
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation <i>tau</i> (2000)

The tau mutation is a semidominant autosomal allele that dramatically shortens period length of circadian rhythms in Syrian hamsters. We report the molecular identification of the tau locus using genetically directed representational difference analysis to define a region of conserved synteny in hamsters with both the mouse and human genomes. The tau locus is encoded by casein kinase I epsilon (CKIepsilon), a homolog of the Drosophila circadian gene double-time. In vitro expression and functional studies of wild-type and tau mutant CKIepsilon enzyme reveal that the mutant enzyme has a markedly reduced maximal velocity and autophosphorylation state. In addition, in vitro CKIepsilon can interact with mammalian PERIOD proteins, and the mutant enzyme is deficient in its ability to phosphorylate PERIOD. We conclude that tau is an allele of hamster CKIepsilon and propose a mechanism by which the mutation leads to the observed aberrant circadian phenotype in mutant animals.
Additional New Maytansinoids from Trewia nudiflora: 10-Epitrewiasine and Nortrewiasine (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditional New Maytansinoids from Trewia nudiflora: 10-Epitrewiasine and NortrewiasineRichard G. Powell, Cecil R. Smith Jr., Ronald D. Plattner, and Barry E. JonesCite this: J. Nat. Prod. 1983, 46, 5, 660–666Publication Date (Print):September 1, 1983Publication History Published online1 July 2004Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/np50029a012https://doi.org/10.1021/np50029a012research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential Response of Common Bean Cultivars to <i>Phakopsora pachyrhizi</i> (2007)

Soybean rust (Phakopsora pachyrhizi) has been reported on common bean (Phaseolus vulgaris) in Asia, South Africa, and the United States. However, there is little information on the interaction of individual isolates of Phakopsora pachyrhizi with common bean germplasm. A set of 16 common bean cultivars with known genes for resistance to Uromyces appendiculatus, the causal agent of common bean rust, three soybean accessions that were sources of the single gene resistance to P. pachyrhizi, and the moderately susceptible soybean 'Ina' were evaluated using seedlings inoculated with six isolates of P. pachyrhizi. Among the common bean cultivars, Aurora, Compuesto Negro Chimaltenango, and Pinto 114, were the most resistant to all six P. pachyrhizi isolates, with lower severity, less sporulation, and consistent reddish-brown (RB) lesions associated with resistance in soybean. A differential response was observed among the common bean cultivars, with a cultivar-isolate interaction for both severity and sporulation levels, as well as the presence or absence of the RB lesion type. This differential response was independent of the known genes that condition resistance to U. appendiculatus, suggesting that resistance to P. pachyrhizi was independent of resistance to U. appendiculatus.
Synergistic Antioxidant and Anti‐Inflammatory Effects between Modified Citrus Pectin and Honokiol (2017)

Inflammation is a normal physiological process; however, dysregulation of this process may contribute to inflammatory-based chronic disorders and diseases in animals and humans. Therefore, the antioxidant and anti-inflammatory properties of natural products, often recognized in traditional medicine systems, represent therapeutic modalities to reduce or prevent uncontrolled inflammatory processes which in turn potentially ameliorate or prevent sequelae of inflammatory-based symptoms of chronic diseases. We have investigated the antioxidant and anti-inflammatory effects of honokiol (HNK) and modified citrus pectin (MCP) <i>in vitro</i> and examined whether the MCP : HNK combination has synergistic effects on antioxidant and anti-inflammatory properties. Although both HNK and MCP induced a dose-dependent increase in antioxidant activity, the latter has a consistently higher antioxidant effect. The MCP : HNK (9 : 1) combination induced a synergistic effect on antioxidant activity suggesting that the combination is significantly more efficacious than individual compounds. In mouse monocytes, the lipopolysaccharide- (LPS-) induced tumor necrosis-<i>α</i> (TNF-<i>α</i>) synthesis was significantly inhibited by HNK and the MCP : HNK combination in a dose-dependent manner and synergistic effects were clearly demonstrated with the combination on TNF-<i>α</i> inhibition. This combination effect was also evident on inhibition of nuclear factor-kappa B activity, cyclooxygenase-II activity, and lipid peroxidation in mouse monocytes. Further research into the combination is warranted.
Cerebral Blood Flow Quantification Using Vessel-Encoded Arterial Spin Labeling (2013)

Arterial spin labeling (ASL) techniques are gaining popularity for visualizing and quantifying cerebral blood flow (CBF) in a range of patient groups. However, most ASL methods lack vessel-selective information, which is important for the assessment of collateral flow and the arterial supply to lesions. In this study, we explored the use of vessel-encoded pseudocontinuous ASL (VEPCASL) with multiple postlabeling delays to obtain individual quantitative CBF and bolus arrival time maps for each of the four main brain-feeding arteries and compared the results against those obtained with conventional pseudocontinuous ASL (PCASL) using matched scan time. Simulations showed that PCASL systematically underestimated CBF by up to 37% in voxels supplied by two arteries, whereas VEPCASL maintained CBF accuracy since each vascular component is treated separately. Experimental results in healthy volunteers showed that there is no systematic bias in the CBF estimates produced by VEPCASL and that the signal-to-noise ratio of the two techniques is comparable. Although more complex acquisition and image processing is required and the potential for motion sensitivity is increased, VEPCASL provides comparable data to PCASL but with the added benefit of vessel-selective information. This could lead to more accurate CBF estimates in patients with a significant collateral flow.
Multiplex Assay for Simultaneous Measurement of Antibodies to Multiple <i>Plasmodium falciparum</i> Antigens (2006)

Antibodies to Plasmodium falciparum are classically measured using the enzyme-linked immunosorbent assay (ELISA). Although highly sensitive, this technique is labor-intensive when large numbers of samples must be screened against multiple antigens. The suspension array technology (SAT) might be an alterative to ELISA, as it allows measurement of antibodies against multiple antigens simultaneously with a small volume of sample. This study sought to adapt the new SAT multiplex system for measuring antibodies against nine malarial vaccine candidate antigens, including recombinant proteins from two variants of merozoite surface protein 1, two variants of apical merozoite antigen 1, erythrocyte binding antigen 175, merozoite surface protein 3, and peptides from the circumsporozoite protein, ring erythrocyte surface antigen, and liver-stage antigen 1. Various concentrations of the antigens were coupled to microspheres with different spectral addresses, and plasma samples from Cameroonian adults were screened by SAT in mono- and multiplex formats and by ELISA. Optimal amounts of protein required to perform the SAT assay were 10- to 100-fold less than that needed for ELISA. Excellent agreement was found between the single and multiplex formats (R > or = 0.96), even when two variants of the same antigen were used. The multiplex assay was rapid, reproducible, required less than 1 mul of plasma, and had a good correlation with ELISA. Thus, SAT provides an important new tool for studying the immune response to malaria rapidly and efficiently in large populations, even when the amount of plasma available is limited, e.g., in studies of neonates or finger-prick blood.
A Comprehensive Review of Thermal Enhanced Oil Recovery: Techniques Evaluation (2018)

The oil production from any well passes through three stages. The first stage is the natural extraction of oil under the well pressure, the second stage starts when the well pressure decreases. This second stage includes flooding the well with water via pumping sea or brackish water to increase the well pressure and push the oil up enhancing the oil recovery. After the first and secondary stages of oil production from the well, 20–30% of the well reserve is extracted. The well is said to be depleted while more than 70% of the oil are left over. At this stage, the third stage starts and it is called the enhanced oil recovery (EOR) or tertiary recovery. Enhanced oil recovery is a technology deployed to recover most of our finite crude oil deposit. With constant increase in energy demands, EOR will go a long way in extracting crude oil reserve while achieving huge economic benefits. EOR involves thermal and/or nonthermal means of changing the properties of crude oil in reservoirs, such as density and viscosity that ensures improved oil displacement in the reservoir and consequently better recovery. Thermal EOR, which is the focus of this paper, is considered the dominant technique among all different methods of EOR. In this paper, we present a brief overview of EOR classification in terms of thermal and nonthermal methods. Furthermore, a comprehensive review of different thermal EOR methods is presented and discussed.
Abstract 4037: Downregulation of ZNF516 and INTS1 is related with promoter methylation in cervical uterine cancer cell lines (2012)

Abstract Introduction: One of the most common neoplasia in developing countries is cervical uterine carcinoma (CC). HPV infection is recognized as the major risk factor for carcinogenesis of cervix. However, not all infected women will develop a cervical cancer. Several studies have proposed DNA methylation as early biomarker in CC. A higher promoter methylation is associated with lower gene expression. Aim: To evaluate the association between DNA methylation and gene expression of ZNF516 and INTS1 in cervical cancer cell lines. Materials and Methods: DNA isolated from 12 normal and 7 cervical cancer tissue samples was enriched by Methylated DNA Immunoprecipitation (MeDIP) and hybridized to Nimblegen 385K CpG Islands plus Promoter arrays (MeDIP-chip). Bioinformatics strategies were used for background correction, array normalization and data analysis of differentially methylated genomic regions by Methylation Specific PCR in a cohort of 221 normal, premalignant, and cervical cancer samples. Relative expression analysis was performed in a normal cervical epithelium cell line (ECT1 E6/E7) and three cervical cancer cell lines (C-4I, SiHa and C-33A) using real time PCR. MSP was also used to examine promoter methylation in normal cervical and cervical cancer cells lines. Results: ZNF516 and INTS1 were differential methylated in the promoter region of normal and cervical cancer samples in the MeDIP-chip discovery project. The methylation frequency was 100% in cervical cancer cell lines. Relative expression of ZNF516 was significantly lower in C-4I and SiHa (p &lt;0.05) in relation with the normal cell line. C-33A showed elevated promoter methylation and a low expression of ZNF516, however, this result was not significant. INTS1 expression was significantly lower in C-33A and SiHa (p &lt;0.05) in relation with the normal cell line. C-4I showed a high promoter methylation and a low expression of INTS1, however, this result was not significant. Conclusions: We have identified ZNF516 and INTS1 as potentials biomarkers for cervical cancer. These genes may be a useful tool for diagnosis and clinical management of cervical cancer. These results need to be confirmed in clinical samples, from an independent laboratory before the gene panel is examined in a Phase II Biomarker Development Trial. Work sponsored by CORFO Project 09CN14-5960 and Postdoctoral Fondecyt Research Project 3120141. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4037. doi:1538-7445.AM2012-4037
Delay-Energy Tradeoffs in Wireless Ad-Hoc Networks with Partial Channel State Information (2008)

Given a wireless network where each link undergoes small-scale (Rayleigh) fading, we consider the problem of routing a message from a source node to a target node while minimizing energy or power expenditure given a fixed time budget, or vice versa. Given instantaneous channel state information, we develop tight hyperbolic bounds on the quantities of interest and solve the related optimizations in closed form or via lightweight computations. If only average channel state information is available, probabilistical performance measures must be introduced. We therefore develop another set of bounds that supports resource-optimal routing with a guaranteed success probability. Our results rest on novel formulations and solution methods for hyperbolic convex programs and, more generally, nonlinear multicriterion combinatorial optimization.
Cell-aware analysis for small-delay effects and production test results from different fault models (2011)

This paper focuses on a new approach to significantly improve the overall defect coverage for CMOS-based designs with the final goal to eliminate any system-level test. This methodology describes the pattern generation flow for detecting cell-internal small-delay defects caused by cell-internal resistive bridges. Results have been evaluated on 1,900 library cells of a 32-nm technology. First production test results are presented from evaluating additional defect detections achieved with different fault models on a 45-nm design.
New horizons in the analysis of circulating cell-derived microparticles (2004)

Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focuses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.
A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506) (2015)

Despite substantial improvement in microsurgical techniques for nerve repair, recovery after peripheral nerve injury is usually incomplete. FK506, an FDA approved immunosuppressant, improves functional recovery and reinnervation following peripheral nerve injury in animal models. However, systemically delivered FK506 causes undesirable global immunosuppression. We have, therefore, engineered a biodegradable local delivery system for FK506 using fibrin gel as a drug reservoir that could be placed at a site of nerve injury. FK506 was incorporated into fibrin gel in solubilized, particulated, and poly(lactic-co-glycolic) acid (PLGA) microspheres-encapsulated forms. A tunable release of FK506 in the fibrin gel from days to weeks was observed with the rate of release being most rapid for the solubilized form and then the particulate form. The most prolonged period of release was seen with the PLGA microsphere-encapsulated form. As analyzed by in vitro dorsal root ganglion (DRG) neurite extension assay, PLGA microsphere encapsulation of FK506 did not alter the drug's properties and the released FK506 maintained its bioactivity over the entire period of release. This study suggests that local delivery of FK506 with fibrin hydrogel could be used to enhance peripheral nerve regeneration.
Asymmetric flexure for pendulous accelerometer (1991)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Graeme A. Blake, Brian L. Norling, Mitchell J. Novack; Asymmetric flexure for pendulous accelerometer. J. Acoust. Soc. Am. 1 July 1991; 90 (1): 623. https://doi.org/10.1121/1.401227 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
3D Shape Retrieval using Volumetric and Image CNNs: A Meta-Algorithmic Approach (2018)

We propose a deep learning method to retrieve the most similar 3D well-designed model that our system has seen before, given a rough 3D model or scanned 3D data. We can either use this retrieved model directly or use it as a reference to redesign it for various purposes. Our neural network consists of 3 different neural networks (sub-nets). The first neural network deals with object images (2D projection) and the other two deals with voxel representations of the 3D object. At the last stage, we combine the results of all 3 sub-nets to get the object classification. Furthermore, we use the second to last layer as a feature map to do the feature matching, and return a list of top N most similar well-designed 3D models.
Graph based event detection from realistic videos using weak feature correspondence (2010)

We study the problem of event detection from realistic videos with repetitive sequential human activities. Despite the large body of work on event detection and recognition, very few have addressed low-quality videos captured from realistic environments. Our framework is based on solving the shortest path on a temporal-event graph constructed from the video content. Graph vertices correspond to detected event primitives, and edge weights are set according to generic knowledge of the event patterns and the discrepancy between event primitives based on a greedy matching of their visual features. Experimental results on videos collected from a retail environment validate the usefulness of the proposed approach.
Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression (2021)

Glutathione (GSH) is an important antioxidant that plays a critical role in neuroprotection. GSH depletion in neurons induces oxidative stress and thereby promotes neuronal damage, which in turn is regarded as a hallmark of the early stage of neurodegenerative diseases. The neuronal GSH level is mainly regulated by cysteine transporter EAAC1 and its inhibitor, GTRAP3-18. In this study, we found that the GTRAP3-18 level was increased by up-regulation of the microRNA miR-96-5p, which was found to decrease EAAC1 levels in our previous study. Since the 3'-UTR region of GTRAP3-18 lacks the consensus sequence for miR-96-5p, an unidentified protein should be responsible for the intermediate regulation of GTRAP3-18 expression by miR-96-5p. Here, we discovered that RNA-binding protein NOVA1 functions as an intermediate protein for GTRAP3-18 expression via miR-96-5p. Moreover, we show that intra-arterial injection of a miR-96-5p-inhibiting nucleic acid to living mice by a drug delivery system using microbubbles and ultrasound decreased the level of GTRAP3-18 via NOVA1 and increased the levels of EAAC1 and GSH in the dentate gyrus of the hippocampus. These findings suggest that the delivery of a miR-96-5p inhibitor to the brain would efficiently increase the neuroprotective activity by increasing GSH levels via EAAC1, GTRAP3-18 and NOVA1.
Effects of elevated temperature treatments in microstructure release procedures (1995)

Elevated temperature solvent rinses are shown to reduce stiction of micromechanical structures after release etch processing. Rinsing the structures in boiling methanol after rinsing in water significantly improves yields. Photographs taken during the drying process indicate two distinct modes of solvent vaporization, one of which leads to stiction. This process can be modeled and used to predict the critical length of cantilevered beams above which stiction occurs. A key element of this model is that the dynamics of the drying process are strongly influenced by the shape of the microstructure perimeter. The decrease in stiction cannot be explained solely by liquid bridging modeling in case of elevated rinse temperature. Stiction can be further decreased by drying at high temperature in a rapid thermal annealer; this suggests that instability of the trapped liquid under tension at elevated temperatures may be a dominant factor in reducing the stiction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>