gebhart/patrepeval huggingface dataset:
Sentinel Lymph Node Mapping with Isosulfan Blue or Indocyanine Green in Colon Cancer Shows Comparable Results and Identifies Patients with Decreased Survival: A Prospective Single‐Center Trial (2017)

This study demonstrates a high diagnostic accuracy for both the IB and the ICG SLN-mapping. SLN-mapping upstaged a quarter of patients with node negative colon cancer, and the detected ITC and micro-metastases were an independent negative prognostic marker in multivariate analysis.
Molecular architecture of the neuromuscular junction (2005)

The neuromuscular junction (NMJ) is a complex structure that serves to efficiently communicate the electrical impulse from the motor neuron to the skeletal muscle to signal contraction. Over the last 200 years, technological advances in microscopy allowed visualization of the existence of a gap between the motor neuron and skeletal muscle that necessitated the existence of a messenger, which proved to be acetylcholine. Ultrastructural analysis identified vesicles in the presynaptic nerve terminal, which provided a beautiful structural correlate for the quantal nature of neuromuscular transmission, and the imaging of synaptic folds on the muscle surface demonstrated that specializations of the underlying protein scaffold were required. Molecular analysis in the last 20 years has confirmed the preferential expression of synaptic proteins, which is guided by a precise developmental program and maintained by signals from nerve. Although often overlooked, the Schwann cell that caps the NMJ and the basal lamina is proving to be critical in maintenance of the junction. Genetic and autoimmune disorders are known that compromise neuromuscular transmission and provide further insights into the complexities of NMJ function as well as the subtle differences that exist among NMJ that may underlie the differential susceptibility of muscle groups to neuromuscular transmission diseases. In this review we summarize the synaptic physiology, architecture, and variations in synaptic structure among muscle types. The important roles of specific signaling pathways involved in NMJ development and acetylcholine receptor (AChR) clustering are reviewed. Finally, genetic and autoimmune disorders and their effects on NMJ architecture and neuromuscular transmission are examined.
A New Copolymer Containing Perylene Bisimide and Porphyrin Moieties: Synthesis and Characterization (2005)

Abstract Summary: A novel copolymer containing perylene bisimide and porphyrin units was synthesized through a Wittig‐type coupling reaction and characterized. An electrochemical experiment showed its electronic properties. Optoelectronic measurements showed a steady and rapid cathodic photocurrent response of the polymer film. The features of copolymer colloids were also studied by UV‐Vis spectrometry and TEM. A large quantity of nanoparticles were observed with TEM, with a mean diameter of 200 nm. The size effect leads the absorption wavelength of the nanoparticles to be red‐shifted, which is consistent with the results of UV‐Vis spectrometry. TEM image of the polymer colloid. magnified image TEM image of the polymer colloid.
Improving test case generation for web applications using automated interface discovery (2007)

With the growing complexity of web applications, identifying web interfaces that can be used for testing such applications has become increasingly challenging. Many techniques that work effectively when applied to simple web applications are insufficient when used on modern, dynamic web applications, and may ultimately result in inadequate testing of the applications' functionality. To address this issue, we present a technique for automatically discovering web application interfaces based on a novel static analysis algorithm. We also report the results of an empirical evaluation in which we compare our technique against a traditional approach. The results of the comparison show that our technique can (1) discover a higher number of interfaces and (2) help generate test inputs that achieve higher coverage.
Methotrexate Is a JAK/STAT Pathway Inhibitor (2015)

Aminopterin and methotrexate represent the first chemotherapy agents developed and act as competitive inhibitors of DHFR. Methotrexate is also widely used at low doses to treat inflammatory and immune-mediated conditions including rheumatoid arthritis. In this low-dose regime, folate supplements are given to mitigate side effects by bypassing the biochemical requirement for DHFR. Although independent of DHFR, the mechanism-of-action underlying the low-dose effects of methotrexate is unknown. Given that multiple pro-inflammatory cytokines signal through the pathway, we suggest that suppression of the JAK/STAT pathway is likely to be the principal anti-inflammatory and immunosuppressive mechanism-of-action of low-dose methotrexate. In addition, we suggest that patients with JAK/STAT-associated haematological malignancies may benefit from low-dose methotrexate treatments. While the JAK1/2 inhibitor ruxolitinib is effective, a £43,200 annual cost precludes widespread adoption. With an annual methotrexate cost of around £32, our findings represent an important development with significant future potential.
Dielectric loss law of asphalt mixture under the condition of microwave heating (2014)

In order to improve energy conversion efficiency of asphalt mixture during microwave heating, key characteristic parameters are researched. Attenuation law of electric field intensity and dielectric loss in asphalt mixture are discussed and conversion model between thermal field and electric field is built. Results show that: (1) electric field intensity attenuates with the increase of the measuring depth of microwave, and the utilization rate of electromagnetic energy increases with attenuation constant; (2) electric field intensity also attenuates with the increase of dielectric permittivity and dielectric loss tangent of asphalt mixture; (3) temperature of asphalt mixture can be significantly improved by enhancing intensity of internal heat source. The findings can provide the theoretical basis for selection of asphalt pavement material, establishment of microwave recycling theory and design of microwave heating equipments.
Quaternary Ammonium (Hypo)iodite Catalysis for Enantioselective Oxidative Cycloetherification (2010)

It is desirable to minimize the use of rare or toxic metals for oxidative reactions in the synthesis of pharmaceutical products. Hypervalent iodine compounds are environmentally benign alternatives, but their catalytic use, particularly for asymmetric transformations, has been quite limited. We report here an enantioselective oxidative cycloetherification of ketophenols to 2-acyl-2,3-dihydrobenzofuran derivatives, catalyzed by in situ-generated chiral quaternary ammonium (hypo)iodite salts, with hydrogen peroxide as an environmentally benign oxidant. The optically active 2-acyl 2,3-dihydrobenzofuran skeleton is a key structure in several biologically active compounds.
Chaotic lidar (2004)

A novel chaotic lidar (CLIDAR) system that utilizes a chaotic laser as the light source is proposed and studied. In CLIDAR, the detection and ranging are realized by correlating the signal waveform reflected back from the target with a delayed reference waveform. Benefiting from the very broad bandwidth of the chaotic waveform that can be easily generated by a semiconductor laser, a centimeter-range resolution is readily achieved. The correlation performance of CLIDAR is studied both numerically and experimentally. The power spectra, phase portraits, time series, and correlation traces of the chaotic waveforms obtained at different operating conditions are compared. The relation between the complexity of the attractor and the correlation property is examined. The correlation dimension and the largest positive Lyapunov exponent of each waveform are calculated. To compare the correlation performance of the waveforms quantitatively, peak sidelobe levels of the correlation traces with different correlation lengths and relative noise levels are investigated. Preliminary experiments show a subcentimeter accuracy in ranging with a 3-cm-range resolution, which currently is limited by the bandwidth of the oscilloscope used.
A taxonomy for describing matching and scheduling heuristics for mixed-machine heterogeneous computing systems (2002)

The problem of mapping (defined as matching and scheduling) tasks and communications onto multiple machines and networks in a heterogeneous computing (HC) environment has been shown to be NP-complete, in general, requiring the development of heuristic techniques. Many different types of mapping heuristics have been developed in recent years. However, selecting the best heuristic to use in any given scenario remains a difficult problem. Factors making this selection difficult are discussed. Motivated by these difficulties, a new taxonomy for classifying mapping heuristics for HC environments is proposed (Purdue HC Taxonomy). The taxonomy is defined in three major parts: the models used for applications and communication requests; the models used for target hardware platforms; and the characteristics of mapping heuristics, Each part of the taxonomy is described, with examples given to help clarify the taxonomy. The benefits and uses of this taxonomy are also discussed.
Alkylboronic Esters from Copper‐Catalyzed Borylation of Primary and Secondary Alkyl Halides and Pseudohalides (2011)

Easy access: An unprecedented copper-catalyzed cross-coupling reaction of the title compounds with diboron reagents is described (see scheme; Ts = 4-toluenesulfonyl). This reaction can be used to prepare both primary and secondary alkylboronic esters having diverse structures and functional groups. The resulting products would be difficult to access by other means.
Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population (1994)

To estimate the extent of meningococcal carriage in the Norwegian population and to investigate the relationship of several characteristics of the population to the carrier state, 1,500 individuals living in rural and small-town areas near Oslo were selected at random from the Norwegian National Population Registry. These persons were asked to complete a questionnaire and to volunteer for a bacteriological tonsillopharyngeal swab sampling. Sixty-three percent of the selected persons participated in the survey. Ninety-one (9.6%) of the volunteers harbored Neisseria meningitidis. The isolates were serogrouped, serotyped, tested for antibiotic resistance, and analyzed by multilocus enzyme electrophoresis. Eight (8.8%) of the 91 isolates represented clones of the two clone complexes that have been responsible for most of the systemic meningococal disease in Norway in the 1980s. Age between 15 and 24, male sex, and active and passive smoking were found to be independently associated with meningococcal carriage in logistic regression analyses. Working outside the home and having an occupation in transportation or industry also increased the risk for meningococcal carriage in individuals older than 17, when corrections for gender and smoking were made. Assuming that our sample is representative of the Norwegian population, we estimated that about 40,000 individuals in Norway are asymptomatic carriers of isolates with epidemic potential. Thus, carriage eradication among close contacts of persons with systemic disease is unlikely to have a significant impact on the overall epidemiological situation.
Impaired adenosine-5′-triphosphate release from red blood cells promotes their adhesion to endothelial cells: A mechanism of hypoxemia after transfusion* (2011)

The normal flow of red blood cells in pulmonary microvessels depends in part on the release of antiadhesive adenosine-5'-triphosphate from red blood cells, and storage-induced deficiency in adenosine-5'-triphosphate release from transfused red blood cells may promote or exacerbate microvascular pathophysiology in the lung, in part through increased red blood cell adhesion.
New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA (2010)

Two archaeal tRNA methyltransferases belonging to the SPOUT superfamily and displaying unexpected activities are identified. These enzymes are orthologous to the yeast Trm10p methyltransferase, which catalyses the formation of 1-methylguanosine at position 9 of tRNA. In contrast, the Trm10p orthologue from the crenarchaeon <it>Sulfolobus acidocaldarius</it> forms 1-methyladenosine at the same position. Even more surprisingly, the Trm10p orthologue from the euryarchaeon <it>Thermococcus kodakaraensis</it> methylates the <it>N</it>1-atom of either adenosine or guanosine at position 9 in different tRNAs. This is to our knowledge the first example of a tRNA methyltransferase with a broadened nucleoside recognition capability. The evolution of tRNA methyltransferases methylating the <it>N</it>1 atom of a purine residue is discussed.
Electrochemical performance of W-doped anatase TiO2 nanoparticles as an electrode material for lithium-ion batteries (2011)

This paper describes a method to prepare tungsten doped anatase TiO2 (WTO) nanoparticles with high surface area based on a polymer-assisted sol–gel process and using simple chemical reagents. The samples are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (including high-resolution imaging-HRTEM), X-ray photoelectron spectroscopy (XPS), and Brunauer–Emmett–Teller (BET). WTO nanoparticles are obtained with small particle size (ca. 9 nm in mean grain size) and good crystallinity. The as-prepared samples are used as an electrode material for a lithium-ion battery, whose charge–discharge properties, cyclic voltammetry, and cycle performance are examined and revealed to have very good properties. A highly stable capacity of 170 mA h g−1 is found after 100 cycles.
Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines. (1998)

Acyclic nucleoside phosphonates (ANPs) possess a broad-spectrum activity against DNA viruses and retroviruses. HPMPC (cidofovir) has proved to be effective in the treatment of HPV-associated diseases. We have evaluated the effects of various ANPs [i.e., 3-hydroxy-2-phosphonylmethoxypropyl derivatives of adenine (HPMPA) and cytosine (HPMPC, cidofovir)]; cyclic HPMPC (cHPMPC); 9-(2-phosphonylmethoxyethyl) derivatives of adenine (PMEA, adefovir), guanine (PMEG), and 2,6-diaminopurine (PMEDAP); and cyclo-propyl PMEDAP (cPr-PMEDAP), several other antiviral drugs [i.e., acyclovir (ACV), ganciclovir (GCV), foscarnet (PFA), and ribavirin]; the antitumor agents cytarabine (AraC) and 5-fluorouracil (5-FU); and the immunosuppressant mycophenolic acid (MPA) on the proliferation of human cervical keratinocytes immortalized by HPV-33 (CK-1 cells) and the cervical carcinoma cell lines containing HPV-16 (CaSki and SiHa) or HPV-18 (HeLa). In vitro incubation of these cell lines with ANPs resulted in a concentration- and time-dependent inhibition of cell proliferation. This inhibitory effect was most striking for HPMPC. The 50% inhibitory concentration (IC50) of HPMPC decreased from 20-50 microg/ml at day 3 to 0.6-2 microg/ml at day 7. When the IC50 values of the ANPs for the various HPV-harboring cells were compared with those for primary human keratinocytes isolated from normal cervix, HPMPC emerged as the most selective ANP, with a selectivity index (SI) in the range of 15-42. When IC50 values as a function of time were determined for several tumor cell lines (i.e., human melanomas, lung, colon, and breast carcinomas), ANPs again showed an antiproliferative effect as a function of time, although of a lower extent (5- to 25-fold decrease in the IC50 values between days 3 and 7) than for the HPV-positive cells. Treatment of SV40- and adenovirus-transformed cells with ANPs resulted in the inhibition of cell proliferation as a function of time, similar to that observed with HPV-positive cells, HPMPC and cHPMPC being the most potent antiproliferative agents. These results suggest that the antiproliferative activity of ANPs, in particular HPMPC, against HPV-bearing tumor cells may be explained, at least in part, by a specific inhibitory effect on rapidly proliferating cells, and the presence of the HPV genome might enhance the sensitivity of cells to HPMPC due to interactions of the viral-transforming proteins with products of the tumor suppressor genes.
A Divide-and-Conquer Approach to the Summarization of Long Documents (2020)

We present a novel divide-and-conquer method for the neural summarization of long documents. Our method exploits the discourse structure of the document and uses sentence similarity to split the problem into an ensemble of smaller summarization problems. In particular, we break a long document and its summary into multiple source-target pairs, which are used for training a model that learns to summarize each part of the document separately. These partial summaries are then combined in order to produce a final complete summary. With this approach we can decompose the problem of long document summarization into smaller and simpler problems, reducing computational complexity and creating more training examples, which at the same time contain less noise in the target summaries compared to the standard approach. We demonstrate that this approach paired with different summarization models, including sequence-to-sequence RNNs and Transformers, can lead to improved summarization performance. Our best models achieve results that are on par with the state-of-the-art in two two publicly available datasets of academic articles.
Specification-based compaction of directed tests for functional validation of pipelined processors (2008)

Functional validation is a major bottleneck in microprocessor design methodology. Simulation is the widely used method for functional validation using billions of random and biased-random test programs. Although directed tests require a smaller test set compared to random tests to achieve the same functional coverage goal, there is a lack of automated techniques for directed test generation. Furthermore, the number of directed tests can still be prohibitively large. This paper presents a methodology for specification-based coverage analysis and test generation. The primary contribution of this paper is a compaction technique that can drastically reduce the required number of directed test programs to achieve a coverage goal. Our experimental results using a MIPS processor and an industrial processor (e500) demonstrate more than 90% reduction in number of directed tests without sacrificing the functional coverage goal.
A methodology for in-situ and remote sensing of microphysical and radiative properties of contrails as they evolve into cirrus (2012)

Abstract. Contrails and especially their evolution into cirrus-like clouds are thought to have very important effects on local and global radiation budgets, though are generally not well represented in global climate models. Lack of contrail parameterisations is due to the limited availability of in situ contrail measurements which are difficult to obtain. Here we present a methodology for successful sampling and interpretation of contrail microphysical and radiative data using both in situ and remote sensing instrumentation on board the FAAM BAe146 UK research aircraft as part of the COntrails Spreading Into Cirrus (COSIC) study. Forecast models were utilised to determine flight regions suitable for contrail formation and sampling; regions that were both free of cloud but showed a high probability of occurrence of air mass being supersaturated with respect to ice. The FAAM research aircraft, fitted with cloud microphysics probes and remote sensing instruments, formed a distinctive spiral-shaped contrail in the predicted area by flying in an orbit over the same ground position as the wind advected the contrails to the east. Parts of these contrails were sampled during the completion of four orbits, with sampled contrail regions being between 7 and 30 min old. Lidar measurements were useful for in-flight determination of the location and spatial extent of the contrails, and also to report extinction values that agreed well with those calculated from the microphysical data. A shortwave spectrometer was also able to detect the contrails, though the signal was weak due to the dispersion and evaporation of the contrails. Post-flight the UK Met Office NAME III dispersion model was successfully used as a tool for modelling the dispersion of the persistent contrail; determining its location and age, and determining when there was interference from other measured aircraft contrails or when cirrus encroached on the area later in the flight. The persistent contrails were found to consist of small (~10 μm) plate-like crystals where growth of ice crystals to larger sizes (~100 μm) was typically detected when higher water vapour levels were present. Using the cloud microphysics data, extinction co-efficient values were calculated and found to be 0.01–1 km−1. The contrails formed during the flight (referred to as B587) were found to have a visible lifetime of ~40 min, and limited water vapour supply was thought to have suppressed ice crystal growth.
Spatio-temporal filling of missing points in geophysical data sets (2006)

Abstract. The majority of data sets in the geosciences are obtained from observations and measurements of natural systems, rather than in the laboratory. These data sets are often full of gaps, due to to the conditions under which the measurements are made. Missing data give rise to various problems, for example in spectral estimation or in specifying boundary conditions for numerical models. Here we use Singular Spectrum Analysis (SSA) to fill the gaps in several types of data sets. For a univariate record, our procedure uses only temporal correlations in the data to fill in the missing points. For a multivariate record, multi-channel SSA (M-SSA) takes advantage of both spatial and temporal correlations. We iteratively produce estimates of missing data points, which are then used to compute a self-consistent lag-covariance matrix; cross-validation allows us to optimize the window width and number of dominant SSA or M-SSA modes to fill the gaps. The optimal parameters of our procedure depend on the distribution in time (and space) of the missing data, as well as on the variance distribution between oscillatory modes and noise. The algorithm is demonstrated on synthetic examples, as well as on data sets from oceanography, hydrology, atmospheric sciences, and space physics: global sea-surface temperature, flood-water records of the Nile River, the Southern Oscillation Index (SOI), and satellite observations of relativistic electrons.