gebhart/patrepeval huggingface dataset:
<scp>EEG</scp> spectral analysis of <scp>NREM</scp> sleep in a large sample of patients with insomnia and good sleepers: effects of age, sex and part of the night (2016)

Previous studies of the differences between patients with insomnia and good sleepers with regard to quantitative electroencephalographic measures have mostly utilized small samples and consequently had limited ability to account for potentially important confounding factors of age, sex and part of the night. We conducted a power spectral analysis using a large database of sleep electroencephalographic recordings to evaluate differences between patients with insomnia (N = 803) and good sleepers (N = 811), while simultaneously accounting for these factors and their interaction. Comparisons of power as a function of age and part of the night were made between cohorts (patients with insomnia versus good sleepers) by sex. Absolute power in the delta, theta and sigma bands declined with age for both females and males. Females had significantly greater power than males at all ages, and for each band, cohort and part of the night. These sex differences were much greater than differences between patients with insomnia and good sleepers. Compared with good sleepers, patients with insomnia under age 40-45 years had reduced delta band power during Part 1 of the night. Females with insomnia over age 45 years had increased delta and theta band power in Parts 2 and 3 of the night, and males with insomnia under age 40 years had reduced theta power in Part 1. Females with insomnia had increased beta2 power in all parts of the night, and males with insomnia had reduced alpha power during all parts of the night. Relative power (the proportion that an individual frequency band contributes to the total power) decreased in the delta band and increased in all other bands with age for both cohorts, sexes and all parts of the night. This analysis provides a unique resource for quantitative information on the differences in power spectra between patients with insomnia and good sleepers accounting for age, sex and part of the night.
Terabit LAN with optical virtual concatenation for Grid applications with super-computers (2005)

This paper proposes an optical local area network that can transmit terabit-class bulk-data with low latency in a dynamic manner. A group of wavelengths is assigned to bulk-data transmission according to the latency requirement, and parallel WDM signals are transmitted with bit-phase synchronization mechanism after fast provisioning.
Ageing-Aware Charging of Lithium-ion Batteries Using an Electrochemistry-Based Model with Capacity-Loss Side Reactions (2020)

In this paper, we utilize a Doyle-Fuller-Newman (DFN) model including capacity-loss side reactions to present a model-based design method for multi-stage charging protocols. This design method allows making a trade-off between charging time and battery ageing in a more systematic way. The results are leveraged by a highly efficient implementation of the DFN model, that has a short computation time. We show that by obtaining the Pareto front that describes the optimal trade-off between charging time and battery ageing for a single cycle, the results can be extended to the lifetime of the battery. Finally we show that the negative electrode over-potential is not always a good indicator for ageing, and that ageing will occur even when the battery operates in over-potential regions that are considered to not lead to ageing.
Transcription Initiation From Within P Elements Generates Hypomorphic Mutations in Drosophila melanogaster (2020)

Numerous transposable element insertions in Drosophila melanogaster cause hypomorphic mutations. We report that transcription initiation within a region found in many P-element constructs provides an explanation for why some gene function is retained. We detected evidence of this transcription in four different types of P constructs, regardless of whether the insertion was in a coding exon, intron, 5′ untranslated region, or upstream of the gene span.
Stereochemical consequences of orbital symmetry control in the reversible combining of sulfur dioxide with conjugated systems (sulfolene reactions) (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical consequences of orbital symmetry control in the reversible combining of sulfur dioxide with conjugated systems (sulfolene reactions)William L. MockCite this: J. Am. Chem. Soc. 1975, 97, 13, 3666–3672Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/ja00846a017https://doi.org/10.1021/ja00846a017research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A method for estimating along-track velocity of synthetic aperture sonar (2019)

Along-track velocity is critical for synthetic aperture sonar (SAS) imaging, as well as for the navigation of carrier. SAS systems typically measure velocity through a Doppler Velocity Log (DVL), but it is not always available. Based on these, this paper describes a method for estimating the along-track velocity using displaced phase center (DPC) approximation. The main idea of the proposed method is to obtain the displacement of SAS between two adjacent pings using the spatiotemporal cross-correlation coefficient matrix, and then find the along-track velocity by a calculating formula. Simulations and results of real data from lake experiments show that the estimated velocity is quite accurate, and the estimated velocity can be used for carrier navigation and image reconstruction.
Tendon injuries (2017)

Tendons connect muscles to bones, ensuring joint movement. With advanced age, tendons become more prone to degeneration followed by injuries. Tendon repair often requires lengthy periods of rehabilitation, especially in elderly patients. Existing medical and surgical treatments often fail to regain full tendon function.The development of novel treatment methods has been hampered due to limited understanding of basic tendon biology. Recently, it was discovered that tendons, similar to other mesenchymal tissues, contain tendon stem/progenitor cells (TSPCs) which possess the common stem cell properties.The current strategies for enhancing tendon repair consist mainly of applying stem cells, growth factors, natural and artificial biomaterials alone or in combination. In this review, we summarise the basic biology of tendon tissues and provide an update on the latest repair proposals for tendon tears. Cite this article: <i>EFORT Open Rev</i> 2017;2:332-342. DOI: 10.1302/2058-5241.2.160075.
Micro Load Balancing in Data Centers with DRILL (2015)

The trend towards simple data center network fabric strips most network functionality, including load balancing capabilities, out of the network core and pushes them to the edge. We investigate a different direction of incorporating minimal load balancing intelligence into the network fabric and show that this slightly smarter fabric significantly enhances performance. We provide a very simple in-network load balancing scheduling algorithm called DRILL which is purely local to each switch. DRILL leverages local load sensing and randomization concepts to distribute load among multiple paths. Through simulation, we show that this simple approach outperforms CONGA, a recent global edge-based load balancing scheme for data centers. We also formally prove the switch-level stability and throughput-efficiency of DRILL's scheduling algorithm.
Impact of Electronic Data Interchange Technology on JIT Shipments (1994)

We investigates the degree to which increasing vertical information integration using Electronic Data Interchange technology enhances shipment performance of suppliers in a Just-in-Time environment. Our analysis of shipment data in the automobile industry suggests that shipment performance degrades substantially due to increases in part variety and trading partners from diverse industries. However, investments in information technology to support both the sharing of JIT schedules and the establishment of integrated information links are related to significant reduction in the level of shipment discrepancies.
Network localization of hemichorea-hemiballismus (2016)

Strokes causing hemichorea-hemiballismus, while anatomically heterogeneous, localize to a common functional network. Specifically, lesions occur in regions functionally connected to the posterolateral putamen, a region previously implicated in hyperkinetic movement disorders. Lesion network mapping may be useful in identifying the neuroanatomical substrates of heterogeneous lesion-based disorders.
Density-dependent electron transport and precise modeling of GaN high electron mobility transistors (2015)

We report on the direct measurement of two-dimensional sheet charge density dependence of electron transport in AlGaN/GaN high electron mobility transistors (HEMTs). Pulsed IV measurements established increasing electron velocities with decreasing sheet charge densities, resulting in saturation velocity of 1.9 × 107 cm/s at a low sheet charge density of 7.8 × 1011 cm−2. An optical phonon emission-based electron velocity model for GaN is also presented. It accommodates stimulated longitudinal optical (LO) phonon emission which clamps the electron velocity with strong electron-phonon interaction and long LO phonon lifetime in GaN. A comparison with the measured density-dependent saturation velocity shows that it captures the dependence rather well. Finally, the experimental result is applied in TCAD-based device simulator to predict DC and small signal characteristics of a reported GaN HEMT. Good agreement between the simulated and reported experimental results validated the measurement presented in this report and established accurate modeling of GaN HEMTs.
Unsteady Entropy Measurements in a High-Speed Radial Compressor (2008)

The time-dependent relative entropy field at the impeller exit of a centrifugal compressor is measured. This study is part of a broader effort to develop comprehensive measurement techniques that can be applied in the harsh environment of turbomachines. A miniature unsteady entropy probe (diameter of 1.8 mm) is designed and constructed in the present study. The unsteady entropy probe has two components: a one-sensor fast-response aerodynamic probe and a pair of thin-film gauges. The time-dependent total pressure and total temperature are measured from the fast-response aerodynamic probe and pair of thin-film gauges, respectively. The time-dependent relative entropy derived from these two measurements has a bandwidth of 40 kHz and an uncertainty of ±2 J/kg. The measurements show that for operating Condition A, φ=0.059 and ψ=0.478, the impeller exit flowfield is highly three dimensional. Adjacent to the shroud there are high levels of relative entropy and at the midspan there are low and moderate levels. Independent measurements made with a two-sensor aerodynamic probe show that the high velocity of the flow relative to the casing is responsible for the high relative entropy levels at the shroud. On the other hand, at the midspan, a loss free, jet flow region and a channel wake flow of moderate mixing characterize the flowfield. At both the shroud and midspan, there are strong circumferential variations in the relative entropy. These circumferential variations are much reduced when the centrifugal compressor is operated at operating Condition B, φ=0.0365 and ψ=0.54, near the onset of stall. In this condition, the impeller exit flowfield is less highly skewed; however, the time-averaged relative entropy is higher than at the operating Condition A. The relative entropy measurements with the unsteady entropy probe are thus complementary to other measurements, and more clearly document the losses in the centrifugal compressor.
Calibrating laser beam deflection systems for use in atomic force microscopes and cantilever sensors (2006)

Most atomic force microscopes and cantilever-based sensors use an optical laser beam detection system to monitor cantilever deflections. We have developed a working model that accurately describes the way in which a position sensitive photodetector interprets the deflection of a cantilever in these instruments. This model exactly predicts the numerical relationship between the measured photodetector signal and the actual cantilever deflection. In addition, the model is used to optimize the geometry of such laser deflection systems, which greatly simplifies the use of any cantilever-based instrument that uses a laser beam detection system.
Passively Self-Tuning Piezoelectric Energy Harvesting System (2014)

Real world systems that are candidates for vibrational energy harvesting rarely vibrate at a single frequency, nor are these frequencies constant over time. This necessitates that vibration harvesters operate over a wide bandwidth or tune their resonance. Most tunable devices require additional energy or active control to achieve resonance over various frequencies. This work presents a passively self-tuning energy harvester that autonomously adapts its resonant frequency to the input without requiring additional energy. The system consists of a clamped- clamped beam, a movable proof mass, and a piezoelectric patch bonded to the underside of the beam. It demonstrated an open-circuit voltage output of 668 mVrms at 160Hz, 0.65g input excitation. Discrepancies between displacement and voltage magnification factors upon tuning at higher frequencies are discussed, as well as instabilities of the system and sensitivity to proof mass characteristics.
Hybrid GMR Sensor Detecting 950 pT/sqrt(Hz) at 1 Hz and Room Temperature (2018)

Advances in the magnetic sensing technology have been driven by the increasing demand for the capability of measuring ultrasensitive magnetic fields. Among other emerging applications, the detection of magnetic fields in the picotesla range is crucial for biomedical applications. In this work Picosense reports a millimeter-scale, low-power hybrid magnetoresistive-piezoelectric magnetometer with subnanotesla sensitivity at low frequency. Through an innovative noise-cancelation mechanism, the 1/f noise in the MR sensors is surpassed by the mechanical modulation of the external magnetic fields in the high frequency regime. A modulation efficiency of 13% was obtained enabling a final device's sensitivity of ~950 pT/Hz<sup>1/2</sup> at 1 Hz. This hybrid device proved to be capable of measuring biomagnetic signals generated in the heart in an unshielded environment. This result paves the way for the development of a portable, contactless, low-cost and low-power magnetocardiography device.
1H NMR analysis and in vitro bioactivity of Leu27-bGRF(1-29)NH2 and its D-Ala2 and des-(Tyr1-Ala2)-analogs. (1992)

Relative growth hormone-releasing potencies of bovine growth hormone-releasing factor (bGRF) analogs bGRF(1-44)NH2 (I), Leu27-bGRF(1-29)NH2 (II) and D-Ala2, Leu27-bGRF(1-29)NH2 (III) in in vitro bovine anterior pituitary cell cultures were determined to be 100%, 48% and 77%, respectively. The potencies of II and III, although numerically different, were not statistically different. Leu27-bGRF(3-29)NH2 (IV) was approximately 10,000 times less potent than 1. 1H NMR studies of peptides II, III and IV in 35% d3-2,2,2-trifluorethanol (TFE)/65% phosphate buffer at pH 4 revealed very similar, highly helical secondary structures in the 8-29 region, with only subtle differences at the N-termini. This lack of correlation between secondary structure in solution and in vitro bioactivity suggests that either 1) the biological conformations induced at the GRF receptor for II and III vs. IV are different from those generated in TFE/buffer, 2) similar secondary structures may be necessary but not sufficient for the observed bioactivity or 3) residues 1 and 2 of analogs II and III are important contact residues crucial for effective GRF-receptor interaction.
Intracrine angiotensin II functions originate from noncanonical pathways in the human heart (2016)

Although it is well-known that excess renin angiotensin system (RAS) activity contributes to the pathophysiology of cardiac and vascular disease, tissue-based expression of RAS genes has given rise to the possibility that intracellularly produced angiotensin II (Ang II) may be a critical contributor to disease processes. An extended form of angiotensin I (Ang I), the dodecapeptide angiotensin-(1-12) [Ang-(1-12)], that generates Ang II directly from chymase, particularly in the human heart, reinforces the possibility that an alternative noncanonical renin independent pathway for Ang II formation may be important in explaining the mechanisms by which the hormone contributes to adverse cardiac and vascular remodeling. This review summarizes the work that has been done in evaluating the functional significance of Ang-(1-12) and how this substrate generated from angiotensinogen by a yet to be identified enzyme enhances knowledge about Ang II pathological actions.
Reconstitution of hybrid toxin from Fragment A of diphtheria toxin and a subunit of Wistaria floribunda lectin. (1978)

A hybrid protein was prepared in which Fragment A of diphtheria toxin was linked to a monovalent subunit of the lectin from Wistaria floribunda seeds by a disulfide bridge. The hybrid molecule was reconstituted effectively from a reduced mixture of Fragment A and the lectin subunit by oxidation with o-phenanthroline and CuSO4. The monovalent hybrid protein was partially purified and found to be toxic to L cells. The toxicity of the hybrid protein on the cells was blocked by the addition of either N-acetyl-D-galactosamine, which specifically binds to the lectin, or by anti-Fragment A antibody.
γ-secretase inhibitors for treating Alzheimer’s disease: rationale and clinical data (2011)

There are no drugs available for slowing down the rate of deterioration of patients with Alzheimer’s disease (AD). With the aim of altering the natural history of the disease, the pharmaceutical industry has designed and developed several compounds inhibiting γ-secretase, the enzymatic complex generating β-amyloid (Aβ) peptides (Aβ1–40 and Aβ1–42), believed to be involved in the pathophysiological cascade of AD, from amyloid precursor protein (APP). This article briefly reviews the profile of γ-secretase inhibitors that have reached the clinic. Studies in both transgenic and nontransgenic animal models of AD have indicated that γ-secretase inhibitors, administered by the oral route, are able to lower brain Aβ concentrations. However, few data are available on the effects of these compounds on brain Aβ deposition after prolonged administration. γ-secretase inhibitors may cause abnormalities in the gastrointestinal tract, thymus, spleen, skin, and decrease in lymphocytes and alterations in hair color in ex...
Control of Radiation Damage in MoS<sub>2</sub> by Graphene Encapsulation (2013)

Recent dramatic progress in studying various two-dimensional (2D) atomic crystals and their heterostructures calls for better and more detailed understanding of their crystallography, reconstruction, stacking order, etc. For this, direct imaging and identification of each and every atom is essential. Transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) are ideal and perhaps the only tools for such studies. However, the electron beam can in some cases induce dramatic structure changes, and radiation damage becomes an obstacle in obtaining the desired information in imaging and chemical analysis in the (S)TEM. This is the case of 2D materials such as molybdenum disulfide MoS2, but also of many biological specimens, molecules, and proteins. Thus, minimizing damage to the specimen is essential for optimum microscopic analysis. In this article we demonstrate, on the example of MoS2, that encapsulation of such crystals between two layers of graphene allows for a dramatic improvement in stability of the studied 2D crystal and permits careful control over the defect nature and formation in it. We present STEM data collected from single-layer MoS2 samples prepared for observation in the microscope through three distinct procedures. The fabricated single-layer MoS2 samples were either left bare (pristine), placed atop a single-layer of graphene, or finally encapsulated between single graphene layers. Their behavior under the electron beam is carefully compared, and we show that the MoS2 sample "sandwiched" between the graphene layers has the highest durability and lowest defect formation rate compared to the other two samples, for very similar experimental conditions.
Oxygen sensing and response to hypoxia by mammalian cells (1996)

Cells are able to sense reduced oxygen tension and modulate the expression of specific genes in order to adapt to hypoxic conditions. In the carotid body and pulmonary neuroepithelial bodies a heme-containing nicotinamide-adenine dinucleotide phosphate oxidase-coupled potassium channel serves as an oxygen sensor. Membrane depolarization triggers an increase in intracellular calcium levels and cellular responses. Hemoproteins may also sense oxygen In non-depolarizable cells. Hypoxia signal transduction involves protein phosphorylation and is affected by cellular redox state. Src, Ras, Raf and MAP kinases have been implicated in some systems involving hypoxia signal transduction. Gene products that are induced by hypoxia include cytokines, metabolic enzymes, transcription factors, cellular redox regulators and protective proteins. Study of hypoxic activation of erythropoietin gene transcription identified a hypoxia-inducible enhancer and transcription factor HIF-1 (hypoxia-inducible factor 1). Recent evidence suggests that HIF-1 may regulate transcription of hypoxia-inducible genes in a variety of cell types in cooperation with other transcription factors and may play an important role in coupling signal transduction pathways to the transcriptional activation of hypoxia inducible genes.
Inside XML (2000)

From the Publisher:
The XML explosion hardly needs any introduction—it's everywhere and there just seems to be no end to what can be done with XML. While writing to the W3C standards, and keeping up with the pace for corporate implementation, you, the programmer or web developer, will need a comprehensive guide to get you started and show you what XML and its related technologies can do. A thorough guide is imperative to success because you will need to know and understand the full scope of XML from day one in order to work with it successfully. With your time constraints and impossible project schedules, you need a comprehensive guide that fulfills your needs in one complete book. Inside XML is an anchor book that covers both the Microsoft and non-Microsoft approach to XML programming. It covers in detail the hot aspects of XML; such as, DTD's vs. XML Schemas, CSS, XSL, XSLT, Xlinks, Xpointers, XHTML, RDF, CDF, parsing XML in Perl and Java, and much more.