gebhart/patrepeval huggingface dataset:
Quantitative Respirator Fit Testing: Dynamic Pressure Versus Aerosol Measurement (1988)

A noninvasive, fast, inexpensive new fit testing method has been invented which relates the slope of the pressure decay inside a respirator during breath-holding to the fit of the respirator on the wearer's face. The dynamic pressure test has been compared with the conventional aerosol test at different leakage levels. The results of this comparison show that the sensitivity of the dynamic pressure test is similar to that of the aerosol test. The pressure test, however, is independent of leak site and probe location and can be performed on respirators before and after their use.
Synthesis and Structure–Activity Relationship Studies of<i>O</i>-Biphenyl-3-yl Carbamates as Peripherally Restricted Fatty Acid Amide Hydrolase Inhibitors (2013)

The peripherally restricted fatty acid amide hydrolase (FAAH) inhibitor URB937 (3, cyclohexylcarbamic acid 3'-carbamoyl-6-hydroxybiphenyl-3-yl ester) is extruded from the brain and spinal cord by the Abcg2 efflux transporter. Despite its inability to enter the central nervous system (CNS), 3 exerts profound antinociceptive effects in mice and rats, which result from the inhibition of FAAH in peripheral tissues and the consequent enhancement of anandamide signaling at CB1 cannabinoid receptors localized on sensory nerve endings. In the present study, we examined the structure-activity relationships (SAR) for the biphenyl region of compound 3, focusing on the carbamoyl and hydroxyl groups in the distal and proximal phenyl rings. Our SAR studies generated a new series of peripherally restricted FAAH inhibitors and identified compound 35 (cyclohexylcarbamic acid 3'-carbamoyl-5-hydroxybiphenyl-3-yl ester) as the most potent brain-impermeant FAAH inhibitor disclosed to date.
Liquid Air Combined Cycle<sup>TM</sup> for Power and Storage (2023)

Liquid Air Combined Cycle (LACC) is a hybrid liquid air energy storage (LAES) system combining energy storage with a combustion turbine to enable large-scale, long-duration energy storage (LDES) while reducing fuel intensity compared to the current state-of-the-art. The LACC technical approach employs proven equipment (cryogenic refrigeration, storage, tanks, pumps, gas turbines, exhaust heat recovery equipment, and turbines) to limit technical risk to a novel organic Rankine cycle (ORC), which was evaluated during this project and found to be feasible. Moreover, LACC storage is safe and relatively compact, to facilitate siting close to loads and within metropolitan regions. The air storage medium is freely available and eliminates supply chain constraints. LACC uses cryogenic air as a storage medium and a gas turbine as the source of heat to drive the discharge process. LACC is distinguished from other LAES technologies by several factors. The charge and discharge processes are decoupled so that cryogenic liquid air is the only storage medium. Other systems also store the higher temperature thermal energy from the liquefaction process in an additional medium. Subsequently, LACC focuses on maximization of the discharge energy and power. LACC also permits the use of commercially available cryogenic refrigeration and storage technologies to increase competition. This project identified product requirements to support market entry and commercialization of the LACC in modular units of approximately 117 MW, each drawing liquid air from customary cryogenic storage tanks capable of storing 75 GWh of dispatchable energy, more than pumped storage hydro or compressed air energy storage technologies. An economic analysis identified the specific liquid air consumption (quantity of liquid air per unit of discharge energy) as a critical parameter. Minimizing the air consumption reduces the specific capital cost ($/kW) for charging and discharging equipment by reducing the size of piping and turbomachinery. Likewise, the specific cost of energy capacity ($/kWh) is reduced by increasing the energy deliverable from a given size tank. The cycle was analyzed to identify the optimal equipment selection and operating conditions, which in turn were combined with quotes and cost estimates to calculate the cost of energy from an LACC system. A substantial effort was focused on the ORC, which draws low-temperature heat from the gas turbine exhaust and condenses at low temperature using the cryogenic liquid air as a heat sink. Alternative turbomachinery arrangements were evaluated for feasibility and cost. A technology maturation plan lays out a low-risk approach to development of the novel ORC components and demonstration of LACC technology at pilot scale.
Stem Cell-Based Meniscus Tissue Engineering (2011)

Knee meniscus, a fibrocartilaginous tissue, is characterized by heterogeneity in extracellular matrix (ECM) and biomechanical properties, and critical for orthopedic stability, load transmission, shock absorption, and stress distribution within the knee joint. Most damage to the meniscus cannot be effectively healed by the body due to its partial avascular nature; thus, damage caused by injury or age impairs normal knee function, predisposing patients to osteoarthritis. Meniscus tissue engineering offers a possible solution to this problem by generating replacement tissue that may be implanted into the defect site to mimic the function of natural meniscal tissue. To address this need, a multiporous, multilamellar meniscus was formed using silk protein scaffolds and stem cells. The silk scaffolds were seeded with human bone marrow stem cells and differentiated over time in chondrogenic culture in the presence of transforming growth factor-beta 3 to generate meniscus-like tissue in vitro. High cellularity along with abundant ECM leading to enhanced biomechanics similar to native tissue was found. Higher levels of collagen type I and II, sulfated glycosaminoglycans along with enhanced collagen 1-α1, aggrecan, and SOX9 gene expression further confirmed differentiation and matured cell phenotype. The results of this study are a step forward toward biomechanically competent meniscus engineering, reconstituting both form and function of the native meniscus.
Magnetic Properties of the Ternary Systems Pr-Sm-Co and MM-Sm-Co (1973)

Coercivity in the ternary rare earth‐cobalt systems Pr‐Sm‐Co and MM‐Sm‐Co has been measured as a function of composition over a broad range. It is found to increase monotonically with samarium content. These results including the special role of samarium will be interpreted in terms of recent models of coercive force in rare earth‐cobalt magnets.
The<i>omp-1</i>Major Outer Membrane Multigene Family of<i>Ehrlichia chaffeensis</i>Is Differentially Expressed in Canine and Tick Hosts (2002)

Sixteen of 22 omp-1 paralogs encoding 28-kDa-range immunodominant outer membrane proteins of Ehrlichia chaffeensis were transcribed in blood monocytes of dogs throughout a 56-day infection period. Only one paralog was transcribed by E. chaffeensis in three developmental stages of Amblyomma americanum ticks before or after E. chaffeensis transmission to naïve dogs.
Geometric Speckle Reduction. (1986)

Abstract : The presence of speckle in imagery produced with coherent illumination (e.g., synthetic aperture radar) reduces the detectability of objects in the images. It also reduces the effectiveness of some computer algorithms (e.g., edge detection) designed for automatic image analysis. Thus it is desirable to reduce speckle in synthetic aperture radar (SAR) images both to assist radar image interpreters and to preprocess images for automatic recognition algorithms on computers. The goal is to smooth out the speckle but at the same time preserve features of interest like edges, strong returns, etc.
Development of a Unique Small Molecule Modulator of CXCR4 (2012)

We developed a novel small molecule, MSX-122, that is a partial CXCR4 antagonist without mobilizing stem cells, which can be safer for long-term blockade of metastasis than other reported CXCR4 antagonists.
Modular gradient coil: A new concept in high‐performance whole‐body gradient coil design (1999)

A new concept in high-performance MR gradient coil design is presented which we have called the Modular Gradient Coil (MGC). This novel design approach results in an actively shielded whole-body gradient coil containing multiple and independent elements, integrated onto a single former, for generating gradient fields along each of the three axes (x, y, and z). These elements can be energized in a number of configurations, using a single gradient power supply unit (PSU), to generate a whole range of gradient performance levels. The design criteria for the MGC also include a requirement to prohibit peripheral nerve stimulation in all of its modes of operation. This requirement is achieved, while simultaneously providing high performance, by specifying different volumes of gradient linearity for each of the operating modes. Magn Reson Med 42:561–570, 1999. © 1999 Wiley-Liss, Inc.
A Potent Activator of Melanogenesis Identified from Small‐Molecule Screening (2009)

Small molecules that increase the cellular level of melanin can be used to study melanogenesis, and have therapeutic potential for melanin-related diseases such as albinism. We describe the identification of a potent activator of melanogenesis from a targeted combinatorial library. Treating melanocytes with our most active molecule results in a 1.8-fold increase in melanin levels, and an increase in tyrosinase-catalyzed oxidation of L-tyrosine, a key step in melanin biosynthesis.
Super-resolution photoacoustic imaging through a scattering wall (2013)

Imaging through opaque, highly scattering walls is a long sought after capability with potential applications in a variety of fields. The use of wavefront shaping to compensate for scattering has brought a renewed interest as a potential solution to this problem. A key to the practicality of any imaging technique is the capability to focus light without direct access behind the scattering wall. Here, we address this problem using photoacoustic feedback for wavefront optimization. By combining the spatially non-uniform sensitivity of the ultrasound transducer to the generated photoacoustic waves with an evolutionary competition among optical modes, the speckle field develops a single, high intensity focus significantly smaller than the acoustic focus used for feedback. Notably, this method is not limited by the size of the absorber to form a sub-acoustic optical focus. We demonstrate imaging behind a scattering medium with up to ten times improvement in signal-to-noise ratio (SNR) and five to six times sub-acoustic resolution. The results presented here open up opportunities for 3D imaging applications in the diffusive regime beyond the sound wave diffraction-limited resolution, including medical imaging, photothermal therapy, neuroscience, and optogenetics.
A monolithic fully-integrated vacuum-sealed CMOS pressure sensor (2002)

This paper presents an integrated multi-transducer capacitive barometric pressure sensor that is vacuum-sealed at wafer level. The interface circuitry is integrated directly within the sealed reference cavity, making the device immune to parasitic environmental effects. The overall device process merges CMOS circuitry with a dissolved-wafer transducer process and is compatible with bulk- and surface-micromachined transducers. The process employs chemical-mechanical polishing (CMP), anodic bonding, and hermetic lead transfers. The sensor achieves 25 mtorr resolution and is suitable for low-cost packaging. It is composed of a programmable switched-capacitor (SC) readout circuit, five segmented-range pressure transducers, and a reference capacitor, all integrated on a 6.5/spl times/7.5 mm/sup 2/ die using 3 /spl mu/m features.
Inhibition of Lesion Progression by the Penetration of Resins In Vitro: Influence of the Application Procedure (2006)

This study compared the progression of sealed initial enamel lesions penetrated with a fissure sealant (Helioseal, Vivadent) or various adhesives (Heliobond, Excite, Vivadent; Resulcin, Merz; Solobond M, Voco; Prompt L-Pop, 3M-ESPE) after exposure to a demineralizing solution, in vitro. From 27 bovine teeth, 54 enamel specimens were prepared and covered with nail varnish (control), thus obtaining three windows for treatment. After demineralization (pH 5.0; 14 days), two of the windows (A, B) were etched with phosphoric acid (20%; 5 seconds); whereas, the third area served as the control (C). The specimens were divided randomly into six groups (n=9), and the material was applied (90 seconds) either once (A) or twice (B). Light-curing followed each application. Half of the area of each specimen window was then covered with nail varnish, and the samples were again stored in the demineralizing solution (pH 5.0; 14 days). The specimens were cut perpendicular to the surface, and both enamel slabs were studied after infiltration using a fluorescent, low viscous resin (VIRIN) and confocal microscopy (CLSM). Lesion depths were calculated (ImageJ) from the surface to that point in the lesion where the grey values clearly changed to a darker grey. After demineralization, mean lesion depths (SD) (14 days) were measured at 105 (21) microm. The second demineralization led to a mean progression of the lesion depths of 52 (31)%. Adper Prompt L-Pop and Solobond M could not significantly prevent lesion progression after a single application (p > 0.05; t-test); however, the second application of Solobond M significantly decreased lesion progression (p < 0.05; t-test). Helioseal, Heliobond, Resulcin Monobond and Excite showed significantly better inhibition of the demineralization compared to the other materials (p < 0.05; Bonferroni). It can be concluded that the penetration of adhesives into initial lesions inhibited a further demineralization in vitro.
Rendering effective route maps (2001)

Route maps, which depict a path from one location to another, have emerged as one of the most popular applications on the Web. Current computer-generated route maps, however, are often very difficult to use. In this paper we present a set of cartographic generalization techniques specifically designed to improve the usability of route maps. Our generalization techniques are based both on cognitive psychology research studying how route maps are used and on an analysis of the generalizations commonly found in handdrawn route maps. We describe algorithmic implementations of these generalization techniques within LineDrive, a real-time system for automatically designing and rendering route maps. Feedback from over 2200 users indicates that almost all believe LineDrive maps are preferable to using standard computer-generated route maps alone.
Achieving exceptionally high luminescence quantum efficiency by immobilizing an AIE molecular chromophore into a metal–organic framework (2014)

We design a new yellow phosphor with high quantum yield by immobilizing a preselected chromophore into a rigid framework. Coating a blue light-emitting diode (LED) with this compound readily generates white light with high luminous efficacy. The new yellow phosphor demonstrates great potential for use in phosphor-converted white LEDs.
Quadruple Butterfly Coil With Passive Magnetic Shielding for Focused Transcranial Magnetic Stimulation (2017)

Coil design for transcranial magnetic stimulation (TMS) is a critical factor that is constantly being investigated to provide more focused stimulation of the brain. The design of focal coils is important because TMS uses time-varying magnetic fields generated from electromagnetic coils to stimulate a specific region of interest of the brain non-invasively. TMS is a useful tool in both diagnostic and therapeutic purposes for identifying and treating psychiatric and neurological disorders. Currently, TMS is approved by the U.S. Food and Drug Administration for the treatment of chronic depression and is being researched for the treatment of stroke, obsessive compulsive disorder, post-traumatic stress disorder, and Parkinson's disease. In this paper, the authors are proposing to further improve the focality of the quadruple butterfly coil (QBC) by using a high-permeability ferromagnetic material acting as passive magnetic shield. Analyses of the resulting field profiles with 50 heterogeneous head models using a single and double magnetic shield has been conducted at two different positions in the brain: the vertex and the dorsolateral prefrontal cortex. Comparison of the results has been illustrated with the help of QBC and figure-8 coil by using parameters of interest such as maximum electric field intensities in both the brain and the entire head, the volume of the brain receiving strong stimulation intensities, and the surface area of the brain receiving strong stimulation intensities. There is a significant amount of improvement found in focality when the QBC is used with a magnetic shield. With a shield, the coil is still able to maintain a comparable maximum electric field intensity in the targeted region of the brain to that of the original QBC. Although both shielding solutions show significant improvement, no notable difference has been found in the results between single and double shields with the QBC.
Segmentation-based video coding system allowing the manipulation of objects (1997)

This paper presents a generic video coding algorithm allowing the content-based manipulation of objects. This manipulation is possible thanks to the definition of a spatiotemporal segmentation of the sequences. The coding strategy relies on a joint optimization in the rate-distortion sense of the partition definition and of the coding techniques to be used within each region. This optimization creates the link between the analysis and synthesis parts of the coder. The analysis defines the time evolution of the partition, as well as the elimination or the appearance of regions that are homogeneous either spatially or in motion. The coding of the texture as well as of the partition relies on region-based motion compensation techniques. The algorithm offers a good compromise between the ability to track and manipulate objects and the coding efficiency.
Steroidal A ring aryl carboxylic acids: a new class of steroid 5.alpha.-reductase inhibitors (1990)

A series of 17 beta-carbamoyl-1,3,5(10)-estratriene-3-carboxylic acids has been prepared and evaluated in vitro as inhibitors of human and rat prostatic steroid 5 alpha-reductase (EC 1.3.1.30). Potent inhibition of the human enzyme, in particular, was observed and preliminary studies using rat enzyme suggest that the inhibition results from the formation of an enzyme-NADP(+)-inhibitor complex. The compounds were synthesized from estrone, generally employing a differentiated bis-triflate carbonylation strategy.
Exploiting Polypeptide Motifs for the Design of Selective Cu(II) Ion Chemosensors (1998)

The production of fluorescent devices for the sensing and\nreporting of chemical events is currently of significant importance for both chemistry and biology. More specifically, sensors directed toward the detection and measurement divalent copper have enjoyed particular attention. Our focus has been on the production of robust, small-molecule chemosensors that exhibit reversible signaling and operate in aqueous solution at neutral\npH, without the requirement for organic cosolvents. Because the intended use for such a sensor is ultimately for the measurement of environmental or biological samples, sufficient detection selectivity is of prime concern to ensure that a measurement in the appropriate concentration range can be made, even in the presence of elevated levels of competing divalent cations.
Highly Stretchable Carbon Nanotube Transistors with Ion Gel Gate Dielectrics (2014)

Field-effect transistors (FETs) that are stretchable up to 50% without appreciable degradation in performance are demonstrated. The FETs are based on buckled thin films of polyfluorene-wrapped semiconducting single-walled carbon nanotubes (CNTs) as the channel, a flexible ion gel as the dielectric, and buckled metal films as electrodes. The buckling of the CNT film enables the high degree of stretchability while the flexible nature of the ion gel allows it to maintain a high quality interface with the CNTs during stretching. An excellent on/off ratio of >10(4), a field-effect mobility of 10 cm(2) · V(-1) · s(-1), and a low operating voltage of <2 V are achieved over repeated mechanical cycling, with further strain accommodation possible. Deformable FETs are expected to facilitate new technologies like stretchable displays, conformal devices, and electronic skins.
Document Classification Using a Finite Mixture Model (1997)

We propose a new method of classifying documents into categories. The simple method of conducting hypothesis testing over word-based distributions in categories suffers from the data sparseness problem. In order to address this difficulty, Guthrie et.al. have developed a method using distributions based on hard clustering of words, i.e., in which a word is assigned to a single cluster and words in the same cluster are treated uniformly. This method might, however, degrade classification results, since the distributions it employs are not always precise enough for representing the differences between categories. We propose here the use of soft clustering of words, i.e., in which a word can be assigned to several different clusters and each cluster is characterized by a specific word probability distribution. We define for each document category a finite mixture model, which is a linear combination of the probability distributions of the clusters. We thereby treat the problem of classifying documents as that of conducting statistical hypothesis testing over finite mixture models. In order to accomplish this testing, we employ the EM algorithm which helps efficiently estimate parameters in a finite mixture model. Experimental results indicate that our method outperforms not only the method using distributions based on hard clustering, but also the method using word-based distributions and the method based on cosine-similarity.