gebhart/patrepeval huggingface dataset:
Failure strength of four veneered primary stainless steel crowns. (1995)

The purpose of this study was to determine the amount of shear force required to fracture or dislodge the veneered facings of four commercially available veneered primary incisor stainless steel crowns (SSC) and to characterize the veneer failures. Forty Unitek SSCs (#4 left central incisor) were shaped to fit a master die and then 10 each were mailed to four commercial dental laboratories that produce veneered SSCs. The resulting four types of crowns tested were: Cheng Crowns (CC), [Peter Cheng Orthodontic Laboratory]; Kinder Krowns (KK) [Mayclin Dental Studio, Inc]; NuSmile Primary Crowns (NC), [Orthodontic Technologies, Inc]; and Whiter Biter Crown II (WB), [White Bite Inc]. Each crown was cemented onto a standardized die and then thermocycled at 4 degrees C and 55 degrees C for 500 1-min cycles. Each die was then placed into a custom holder on the Instron (Model 4204) testing machine. A force was applied at the incisal edge of the veneer at 148 degrees, (the primary inter-incisal angle), with a crosshead speed of 1 mm/min until the veneer fractured or was dislodged. The mean force (N) required +/- SD to produce failure was, respectively: KK (397.2 +/- 53.0); NC (447.2 +/- 78.5); CC (511.9 +/- 83.4); WB (686.5 +/- 181.4). Analysis of variance (ANOVA) indicated significance at P < 0.0001. A Scheffe's post hoc comparison demonstrated that the Whiter Biter (WB) group required significantly (alpha = 0.05) more force for failure than the other three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Robust fabrication of thin film polyamide-TiO2 nanocomposite membranes with enhanced thermal stability and anti-biofouling propensity (2018)

The development of nano-enabled composite materials has led to a paradigm shift in the manufacture of high-performance nanocomposite membranes with enhanced permeation, thermo-mechanical, and antibacterial properties. The major challenges to the successful incorporation of nanoparticles (NPs) to polymer films are the severe aggregation of the NPs and the weak compatibility of NPs with polymers. These two phenomena lead to the formation of non-selective voids at the interface of the polymer and NPs, which adversely affect the separation performance of the membrane. To overcome these challenges, we have developed a new method for the fabrication of robust TFN reverse osmosis membranes. This approach relies on the simultaneous synthesis and surface functionalization of TiO<sub>2</sub> NPs in an organic solvent (heptane) via biphasic solvothermal reaction. The resulting stable suspension of the TiO<sub>2</sub> NPs in heptane was then utilized in the interfacial (in-situ) polymerization reaction where the NPs were entrapped within the matrix of the polyamide (PA) membrane. TiO<sub>2</sub> NPs of 10 nm were effectively incorporated into the thin PA layer and improved the thermal stability and anti-biofouling properties of the resulting TFN membranes. These features make our synthesized membranes potential candidates for applications where the treatment of high-temperature streams containing biomaterials is desirable.
A 200 mV self-testing encoder/decoder using Stanford ultra-low-power CMOS (2002)

A CMOS test chip that includes a 1k-transistor self-testing encoder/decoder is verifiably error-free at supply voltages down to 20O mV, achieving 1/625 the power-delay product of standard 5 V CMOS. The maximum error-free operating frequency of this circuit as a function of supply and threshold voltage is reported here and voltage scaling of performance is compared with ring-oscillator data reported earlier. The circuit works even when bodies of transistors are forward-biased relative to sources to induce /spl sim/100mV depletion-mode thresholds.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG) (2013)

In this study, we evaluated the frequency and prognostic impact of DNMT3A mutations (DNMT3A(mut)) in 1770 younger adult patients with acute myeloid leukemia (AML) in the context of other genetic alterations and the European LeukemiaNet (ELN) classification. DNMT3A(mut) were found in 20.9% of AMLs and were associated with older age (P < .0001), higher white blood cell counts (P < .0001), cytogenetically normal AML (CN-AML; P < .0001), NPM1 mutations (P < .0001), FLT3 internal tandem duplications (P < .0001), and IDH1/2 mutations (P < .0001). In univariable and multivariable analyses, DNMT3A(mut) did not impact event-free, relapse-free (RFS), or overall survival (OS) in either the entire cohort or in CN-AML; a negative prognostic effect was found only in the ELN unfavorable CN-AML subset (OS, P = .011). In addition, R882 mutations vs non-R882 mutations showed opposite clinical effects-unfavorable for R882 on RFS (all: hazard ratio [HR], 1.29 [P = .026]; CN-AML: HR, 1.38 [P = .018]) and favorable for non-R882 on OS (all: HR, 0.77 [P = .057]; CN-AML: HR, 0.73 [P = .083]). In our statistically high-powered study with minimized selection bias, DNMT3A(mut) represent a frequent genetic lesion in younger adults with AML but have no significant impact on survival end points; only moderate effects on outcome were found, depending on molecular subgroup and DNMT3A(mut) type.
Enzymatic scavenging of oxygen dissolved in water: Application of response surface methodology in optimization of conditions (2012)

In this work, removal of dissolved oxygen in water through reduction by glucose, which was catalyzed by glucose oxidase ? catalase enzyme, was studied. Central composite design (CCD) technique was applied to achieve optimum conditions for dissolved oxygen scavenging. Linear, square and interactions between effective parameters were obtained to develop a second order polynomial equation. The adequacy of the obtained model was evaluated by the residual plots, probability-value, coefficient of determination, and Fisher?s variance ratio test. Optimum conditions for activity of two enzymes in water deoxygenation were obtained as follows: pH=5.6, T=40?C, initial substrate concentration [S] = 65.5 mmol/L and glucose oxidase activity [E] = 252 U/Lat excess amount of catalase. The deoxygenation process during 30 seconds, in the optimal conditions, was predicted 98.2%. Practical deoxygenation in the predicted conditions was achieved to be 95.20% which was close to the model prediction.
A novel approach to digital beamforming (1978)

For many sonar applications, the sensor outputs of a hydrophone array are sampled at a rate significantly higher than that required for waveform reconstruction when digital beamforming is used. The reason for this is that the number of synchronous, or ’’natural,’’ beampointing directions is proportional to the beamformer input rate. This paper presents an implementation of a digital beamformer that achieves the desired synchronous beams while minimizing the sensor channel sampling rate requirement. The technique employs zero padding of sensor data followed by digital interpolation filters to achieve vernier beamformer delays. Interpolation filtering can be done either at the beamformer input or output to minimize processing requirements. The resulting structure realizes a hardware savings since both A/D converter and cable bandwith requirements can be traded off against digital processing complexity to achieve an optimal partitioning.
Studies on the glassy and reaction phases given off by fused-cast AZS blocks and their effects on glass quality (1989)

Fused-cast AZS blocks exude distinctly more glassy phase at temperature cycles in comparison with constant temperature, also for longer term. The reason for this behavior is the liberation of oxygen bubbles during temperature increase by redox equilibrium processes of polyvalent ions. In glass melting tanks for high-alkali silicate glasses this effect leads to formation of bubbles, knots and stones at temperature increase, not only with new, but also with used fused-cast AZS blocks. At the contact between high-alkali silicate glass melts and fused-cast AZS blocks a highly viscous Al2O3-enriched reaction layer with embedded ZrO2 crystals is formed on the block side of the phase boundary due to diffusion processes and chemical reaction. The composition of this glassy reaction layer corresponds to that of the knots in the glass product. During a temperature increase, the liberated bubbles of the fused-cast AZS blocks press parts of the glassy reaction layer with ZrO2 crystals (baddeleyite seam) into the base glass thus leading to the formation of knots and stones.
Fell‐Muir Lecture: Proteoglycans and more – from molecules to biology (2009)

In this article the organization and functional details of the extracellular matrix, with particular focus on cartilage, are described. All tissues contain a set of molecules that are arranged to contribute structural elements. Examples are fibril-forming collagens forming major fibrillar networks in most tissues. The assembly process is regulated by a number of proteins (thrombospondins, LRR-proteins, matrilins and other collagens) that can bind to the collagen molecule and in many cases remain bound to the formed fibre providing additional stability and enhancing networking to other structural networks. One such network is formed by collagen VI molecules assembled to beaded filaments in the matrix catalysed by interactions with small proteoglycans of the LRR-family, which remain bound to the filament providing for interactions via a linker of a matrilin to other matrix constituents like collagen fibres and the large proteoglycans, e.g. aggrecan in cartilage. Aggrecan is contributing an extreme anionic charge density to the extracellular matrix, which by osmotic effects leads to water retention and strive to swelling, resisted by the tensile properties of the collagen fibres. Aggrecan is bound via one end to hyaluronan, including such molecules retained at the cell surface, to form very large molecular entities that interact with other constituents of the matrix, e.g. fibulins that can form their own network. Other important interactions are those with cell surface receptors such as integrins, heparan sulphfate proteoglycans, hyaluronan receptors and others. Many of the molecules with an ability to interact with these receptors can also bind to molecules in the matrix and provide a bridge from the matrix to the cell and induce various responses. In pathology, there is an imbalance in matrix turnover with often excessive proteolytic breakdown. This results in the formation of protein fragments, where cleavage provides information on the active enzyme. Those fragments released can be specifically detected employing antibodies specific to the cleavage site and used to diagnose and monitor e.g. joint disease at early stages.
Are Java Junkies Poor Sports? (1991)

Caffeine is a common constituent of numerous products that we consume on a regular basis. But caffeine is also a drug, which raises the question: Does eating or drinking caffeine conflict with the pursuit of a fit and healthful life-style?
Underpotential Deposition of Cu on Boron-Doped Diamond Thin Films (1998)

The deposition of copper on boron-doped diamond thin-film electrodes was investigated. Three kinds of boron-doped diamond films were studied: a film deposited on a silicon wafer, a second grown on a tungsten substrate, and a third, similar to the first, but surface-amorphized (bombarded) by ion beam irradiation. The films were investigated by a number of techniques. Linear potential sweep experiments in 0.1 M H2SO4 + 0.001 M CuSO4 solution showed that, besides the peak due to bulk copper deposition, a “prewave” peak is present in the voltammogram of the first two electrodes and not in the third one. An electrochemical activation at negative potential was imperative for the appearance of the “prewave” peak. The amount of copper involved was less than 2% of a monolayer. The comparison between spectroscopic and electrochemical investigations leads to the interpretation that the “prewave” peak corresponds to an underpotential deposition of Cu on graphitic inclusions in the diamond electrode, or along the grain boundaries, probably by intercalation.
<i>Ancylostoma ceylanicum</i> in the hamster: observations on the host—parasite relationship during primary infection (1989)

The course of primary infection with a hamster-adapted strain of Ancylostoma ceylanicum was studied in inbred DSN and randomly bred WO/GD and WO/CR hamsters. Infective larvae were administered orally and began to develop in the small intestine without embarking on a tissue migration. Only the occasional larva was detected in other organ sites. It was concluded that the developing larvae moulted on days 3-4 and again to the pre-adult stage about 9-11 days post-infection. Worm burdens in infected hamsters were stable for at least 11 weeks after infection. There was no sudden expulsive phase and some adult worms survived for over 200 days. Overall the sex ratio of worms in groups of hamsters killed concurrently was about 50% although occasionally the ratio was biased in favour of one sex in individual animals. The blood packed cell volume (PCV) was significantly depressed 2 weeks following infection and continued to decline until a point of stability was achieved 4-5 weeks post-infection. The PCV subsequently remained depressed throughout the period of observation. Infected hamsters lost weight if kept in groups, but not when housed in separate cages. Groups of animals which lost weight did not recover to normal values within 11 weeks of infection. It is suggested that this model of hookworm infection has scope for exploring aspects of the host-parasite relationship which the canine models cannot fulfill adequately.
Microwave interferometry of Saturn: Application to the brightness temperature of the rings (1974)

Radio interferometric measurements of Saturn and Saturn's rings are explained. The measurements are limited to Mu is greater than or equal to 3. Data are also given on visibility functions, flux density, and brightness temperature.
The effect of lung inflation on the inspiratory action of the canine parasternal intercostals (2005)

Inflation induces a marked decrease in the lung-expanding ability of the diaphragm, but its effect on the parasternal intercostal muscles is uncertain. To assess this effect, the phrenic nerves and the external intercostals were severed in anesthetized, vagotomized dogs, such that the parasternal intercostals were the only muscles active during inspiration, and the endotracheal tube was occluded at different lung volumes. Although the inspiratory electromyographic activity recorded from the muscles was constant, the change in airway opening pressure decreased with inflation from -7.2+/-0.6 cmH2O at functional residual capacity to -2.2+/-0.2 cmH2O at 20-cmH2O transrespiratory pressure (P<0.001). The inspiratory cranial displacement of the ribs remained virtually unchanged, and the inspiratory caudal displacement of the sternum decreased moderately. However, the inspiratory outward rib displacement decreased markedly and continuously; at 20 cmH2O, this displacement was only 23+/-2% of the value at functional residual capacity. Calculations based on this alteration yielded substantial decreases in the change in airway opening pressure. It is concluded that, in the dog, 1) inflation affects adversely the lung-expanding actions of both the parasternal intercostals and the diaphragm; and 2) the adverse effect of inflation on the parasternal intercostals is primarily related to the alteration in the kinematics of the ribs. As a corollary, it is likely that hyperinflation also has a negative impact on the parasternal intercostals in patients with chronic obstructive pulmonary disease.
Reduced order sliding mode control for pneumatic actuator (1994)

A new position control algorithm, based on sliding mode control, has been developed for a pneumatic cylinder. In the proposed pneumatic system, commercially available two-way on-off solenoid valves have been used. The inherent robustness property of the sliding mode controller makes it easier to select the switching gains of the controller. Moreover, approximate dynamic modeling of the system makes the controller simple. Since in sliding mode control, the states remain on the sliding surface, the motion of the piston is very smooth. This suggests the potential of pneumatic cylinders as actuators for robot manipulators. The controller is hybrid in nature, consisting of an error amplifier, data conversion devices and an 8088 microprocessor along with various digital circuit accessories. Only one feedback device (potentiometer) is used. Velocity is calculated from the sampled position signals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Steroid Receptor Coactivator-3 and Activator Protein-1 Coordinately Regulate the Transcription of Components of the Insulin-Like Growth Factor/AKT Signaling Pathway (2006)

Steroid receptor coactivator (SRC)-3, also called amplified in breast cancer 1, is a member of the p160 nuclear receptor coactivator family involved in transcriptional regulation of target genes. SRC-3 is frequently amplified and/or overexpressed in hormone-sensitive and hormone-insensitive tumors. We reported previously that SRC-3 stimulated prostate cell growth in a hormone-independent manner through activation of AKT signaling pathway. However, the underlying mechanism remains undefined. Here, we exploited the mifepristone-induced SRC-3 LNCaP prostate cancer cell line generated in our laboratory to identify SRC-3-regulated genes by oligonucleotide microarray analysis. We found that SRC-3 up-regulates the expression of multiple genes in the insulin-like growth factor (IGF)/AKT signaling pathway that are involved in cell proliferation and survival. In contrast, knockdown of SRC-3 in PC3 (androgen receptor negative) prostate cancer cells and MCF-7 breast cancer cells reduces their expression. Similarly, in prostate glands of SRC-3 null mice, expressions of these components in the IGF/AKT signal pathway are also reduced. Chromatin immunoprecipitation assay revealed that SRC-3 was directly recruited to the promoters of these genes, indicating that they are direct targets of SRC-3. Interestingly, we showed that recruitment of SRC-3 to two target promoters, IRS-2 and IGF-I, requires transcription factor activator protein-1 (AP-1). Taken together, our results clearly show that SRC-3 and AP-1 can coordinately regulate the transcription of multiple components in the IGF/AKT pathway to ensure ligand-independent cell proliferation and survival of cancer cells.
An ultrasonic transducer for second imaging using a LiNbO/sub 3/ plate with a local ferroelectric inversion layer (2006)

A new lithium niobate (LiNbO3) transducer of separated transmitter-receiver configuration is proposed for application to second harmonic imaging in a high-frequency range. In this transducer, a domain-inverted layer of half the plate thickness is formed selectively by Ti-diffusion and heat treatment in the central part of a LiNbO3 plate. The uniformly polarized surrounding region is used as the transmitter that will generate the fundamental wave component. A transducer with the transmission frequency of 50 MHz and the reception frequency of 100 MHz is fabricated using a 36 degrees rotated Y-cut LiNbO3 plate, and its performance is demonstrated.
Fos-related Antigen 2 Controls Protein Kinase A-induced CCAAT/Enhancer-binding Protein β Expression in Osteoblasts (2004)

Transcription factor CCAAT/enhancer-binding protein beta (C/EBPbeta) plays an important role in hormone-dependent gene expression. In osteoblasts C/EBPbeta can increase insulin-like growth factor I (IGF-I) transcription following treatment with hormones that activate protein kinase A, but little is known as yet about the expression of C/EBPbeta itself in these cells. We initially showed that prostaglandin E2 (PGE2) rapidly enhances C/EBPbeta mRNA and protein expression, and in this study we identified a 3'-proximal region of the C/EBPbeta promoter containing a 541-bp upstream sequence that could account for this effect. PGE2-dependent activation of C/EBPbeta was blocked by expression of a mutated regulatory subunit of protein kinase A or by mutation of two previously identified cAMP-sensitive cis-acting regulatory elements within the promoter between bp -111 and -61. Nuclear protein binding to these elements was induced by PGE2, required new protein synthesis, and was sensitive to antibody to the transcription factor termed Fos-related antigen 2 (Fra-2). Fra-2 cDNA generated from rat osteoblasts by reverse transcriptase PCR was 95% homologous to human Fra-2, and PGE2 rapidly induced Fra-2 mRNA and protein expression. Consistent with these findings, over-expression of Fra-2 significantly increased C/EBPbeta promoter activity in PGE2-induced osteoblasts, whereas expression of Fra-2 lacking its activation domain had a dominant negative inhibitory effect. Together, these results reveal a significant, hormone-dependent role for Fra-2 in osteoblast function, both directly, through its ability to increase new C/EBPbeta gene expression, and indirectly, through downstream C/EBP sensitive genes.
The Epidemiology of Burn Wound Infections: Then and Now (2003)

Burn wound infections are a serious complication of thermal injury. Although pneumonia is now the most important infection in patients with burns, burn wound infection remains a serious complication unique to the burn recipient. The methods for managing thermal injury have evolved during the past 50 years. This evolution has been accompanied by changes in the etiology, epidemiology, and approach to prevention of burn wound infections. In the 1950s, 1960s, and 1970s and into the mid-1980s, burn wounds were treated by the exposure method, with application of topical antimicrobials to the burn wound surface and gradual debridement with immersion hydrotherapy. As early burn wound excision and wound closure became the focal point of burn wound management, accompanied by a change from immersion hydrotherapy to showering hydrotherapy, the rate of burn wound infection appeared to decrease. Few epidemiologic studies have been done since this change in the approach to management of thermal injury. There are few data on the epidemiology of burn wound infections from the era of early excision and closure. Data are needed on infection rates for excised and closed burn wounds, the etiologies of these infections, and the epidemiology and the prevention of such infections. Additional studies are needed on the indications for topical and antimicrobial prophylaxis and selective decontamination of the digestive tract.