gebhart/patrepeval huggingface dataset:
Collaborative hierarchical caching with dynamic request routing for massive content distribution (2012)

Massive content delivery in metropolitan networks has recently gained much attention with the successful deployment of commercial systems and an increasing user popularity. With an enormous volume of content available in the network, as well as the growing size of content owing to the popularity of high-definition video, the exploration of capacity in the caching network becomes a critical issue in providing guaranteed service. Yet, collaboration strategies among cache servers in emerging scenarios, such as IPTV services, are still not well understood so far. In this paper, we propose an efficient collaborative caching mechanism based on the topology derived from a real-world IPTV system, with a particular focus on exploring the capacity of the existing system infrastructure. We observe that collaboration among servers is largely affected by the topology characteristics and heterogeneous capacities of the network. Meanwhile, dynamic request routing within the caching network is strongly coupled with content placement decisions when designing the mechanism. Our proposed mechanism is implemented in a distributed manner, and is amenable to practical deployment. Our simulation results demonstrate the effectiveness of our proposed mechanism, as compared to conventional cache cooperation with static routing schemes.
Reversible strain-induced magnetization switching in FeGa nanomagnets: Pathway to a rewritable, non-volatile, non-toggle, straintronic memory cell for extremely low energy operation (2015)

Reversible straintronic switching of a nanomagnet's magnetization between two stable or metastable states promises ultra-energy-efficient non-volatile memory. Here, we report strain-induced magnetization switching in ~300 nm sized FeGa nanomagnets delineated on a piezoelectric PMN-PT substrate. Voltage of one polarity applied across the substrate generates compressive strain in a nanomagnet and switches its magnetization to one state, while voltage of the opposite polarity generates tensile strain and switches the magnetization back to the original state, resulting in "non-toggle" switching. The two states can encode the two binary bits, and, using the right voltage polarity, one can write either bit deterministically.
Multimedia information access using multiple speaker classifiers (2000)

There have been several new systems for multimedia information access reported in recent years. The system presented here shares many of their aspects, but it differs in a significant way from them; it extends the realm of multimedia access to include speaker-based information. We have already prototyped and reported such a system elsewhere whose main features include SVAPI-based speaker recognition combined with speech recognition for joint text- and speaker-based retrieval from audio and video. A vital component of such a system is speaker identification whose performance degrades for utterances smaller than eight seconds to such an extent that such segments have to be dismissed with a catch-all, neutral label. Here, we use a Bayesian Information Criterion based speaker clustering technique to analyze the same audio data. The results of this classifier are combined with those from our SVAPI-based speaker classifier using a decision integration scheme to produce new labels fo...
Preparation of fiber reinforced titanium diboride and boron carbide composite bodies (1979)

A process is described for uniformly infiltrating woven carbon cloth with either titanium diboride or boron carbide at reduced pressure (15 to 25 torr). The effects of deposition temperature on the uniformity of penetration and on coating rate are described for temperatures from 750 to 1000/sup 0/C and deposit loadings from 20 to 43 vol. %. For the boron carbides, boron composition is discussed and evidence is presented suggesting that propene is the dominant rate controlling reactant.
Electrically Conductive Polyimide Films Containing Gold Surface (1994)

Polyimide films exhibiting high thermo-oxidative stability and including electrically conductive surface layers containing gold made by casting process. Many variations of basic process conditions, ingredients, and sequence of operations possible, and not all resulting versions of process yield electrically conductive films. Gold-containing layer formed on film surface during cure. These metallic gold-containing polyimides used in film and coating applications requiring electrical conductivity, high reflectivity, exceptional thermal stability, and/or mechanical integrity. They also find commercial potential in areas ranging from thin films for satellite antennas to decorative coatings and packaging.
Value of Injection Testing as an Alternative to Conventional Well Testing: Field Experience in a Sour-Oil Reservoir (2007)

Summary Environmental constraints and high costs, especially offshore, are making conventional-well testing less and less feasible and accepted by the public administration. New options were thoroughly evaluated to find a viable alternative to standard production tests for characterizing the well productivity without surface production. An accurate investigation demonstrated that injection tests could provide all the information needed to calculate the well productivity at reasonably low costs and with a good degree of reliability. On the basis of the results of laboratory and field pilot tests, it was proved that injectivity tests could be applied successfully to a real sour-oil field. Laboratory tests proved that brine could be a suitable injection fluid because there were no compatibility problems with the oil and the reservoir rock. It was verified that the interpretation of the pressure transients should be referred to the falloff period rather than to the injection phase. The formation permeability-thickness product (kh) could be identified correctly from the pressure-derivative analysis only if multiphase flow was assumed. The total skin value could also be obtained from the test interpretation. The total skin comprises two components: a mechanical component resulting from permeability damage and a biphase component resulting from fluid interaction in the reservoir. Except for a limited number of cases, the biphase skin can be evaluated only with numerical well testing, provided that the fluid relative permeability curves are available. It was also demonstrated that the biphase component depends mainly on the injection rate but is independent of the formation permeability. Then, the well-known transient equation was applied to determine the well productivity index (PI) based on the kh and the mechanical skin. PI values calculated from injection tests compared satisfactorily with PI values measured from six drillstem tests (DSTs) performed on appraisal wells.
Signature Testing of Analog and RF Circuits: Algorithms and Methodology (2007)

There are mainly two factors responsible for rapidly escalating production test costs of today's RF and high-speed analog circuits: 1) the high cost of high-speed and RF automatic test equipments and 2) long test times required by elaborate performance tests. In this paper, we propose a low-cost signature test methodology for accelerated production testing of analog and RF integrated circuits. As opposed to prior work, the key contribution of this paper is a new test generation algorithm that directly tracks the ability of input test waveforms to predict the test specification values from the observed test response, even in the presence of measurement noise. The response of the device-under-test (DUT) is used as a "signature" from which all of the performance specifications are predicted. The applied test stimulus is optimized in such a way that the error between the measured DUT performances and the predicted DUT performances is minimized. While existing low-cost test approaches have only been applied to low- and medium-frequency analog circuits, the proposed methodology extends low-cost signature testing to RF integrated circuits by incorporating modulation of a baseband test stimulus and subsequent demodulation of the obtained response to obtain the DUT signature. The proposed low-cost solution can be easily built into a load board that can be interfaced to an inexpensive tester
Novel germanium photodetectors fabricated with a diffused junction (2002)

Germanium (Ge) photodetectors are fabricated by growing epitaxial III-V compounds on Ge substrates and by in-situ formation of the PN junction by MOVPE. After material growth, Ge photodetectors are mesa-etched using conventional optoelectronic device processing techniques. By varying the Ge substrate resistivity and the device area, Ge photodetector properties such as reverse leakage current, capacitance, and shunt resistance have been engineered. Such devices have demonstrated leakage currents below 50(mu) A/cm<SUP>2</SUP> at -0.1 V bias. For optoelectronic applications that require high temperature operation, high shunt resistance detectors exhibit leakage currents below (mu) A/cm<SUP>2</SUP> at 80 degree(s)C. Low capacitance devices have measured as little as 275 pF at 0V bias for a 1 mm diameter detector. High shunt resistance devices are a low cost alternative to conventional InGaAs photodiodes in applications such as laser monitor diodes.
How much parallelism is there in irregular applications? (2009)

Irregular programs are programs organized around pointer-based data structures such as trees and graphs. Recent investigations by the Galois project have shown that many irregular programs have a generalized form of data-parallelism called amorphous data-parallelism. However, in many programs, amorphous data-parallelism cannot be uncovered using static techniques, and its exploitation requires runtime strategies such as optimistic parallel execution. This raises a natural question: how much amorphous data-parallelism actually exists in irregular programs?
Polyacrolein microspheres as a new tool in cell biology (1982)

Polyacrolein (PA) microspheres in sizes ranging from 0.04 micron to 40 microns were synthesized. Magnetic and fluorescent PA microspheres were formed by carrying out the polymerization process in the presence of appropriate ferrofluidic or fluorochromic compounds, respectively. The microspheres carry reactive aldehyde groups, through which various ligands, containing primary amino groups, were covalently bound at physiological pH values. The potential use of these microspheres was demonstrated by the specific labelling of fresh human red blood cells (RBC) and by the separation of human RBC from turkey RBC by means of a magnetic field. PA microspheres were also bound covalently to the anti-allergic drug disodium chromoglycate (DSCG) and the conjugate was used for the labelling of rat basophilic leukaemia cells.
Distributed synchronous clocking (1995)

It has historically been difficult to distribute a well-aligned hardware clock throughout the physical extent of a synchronous processor. Traditionally, this task has been accomplished by distributing the output of a central oscillator over a tree-like network, with repeaters at necessary intervals. While straightforward in concept, this method suffers from poor reliability, poor scalability and high skew. In this paper, we present an alternative approach-Distributed Synchronous Clocking-that maintains the simplicity of synchronous operation without suffering the drawbacks of centralized clocking. A network of independent oscillators takes the place of the centralized clock source, providing separate clock signals to the physically distant parts of a computing system. A distributed error correction algorithm effects global phase alignment by utilizing Local comparisons of neighboring oscillator phase. In contrast to centralized clock distribution, distributed clocking has the inherent potential for complete scalability and graceful degradation. However, because oscillator phase is a modular quantity, a naive implementation of distributed synchronous clocking can suffer from mode-lock-the trapping of local oscillator phase in undesirable stable equilibria where global phase is not aligned. We present a simple method for eliminating this problem in k-ary Cartesian meshes and give a proof of its correctness for two-dimensional networks. An electronic implementation is also presented and several engineering issues relating to error tolerance are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Direct solid-phase 125I radioimmunoassay of serum cortisol. (1978)

We report a solid-phase iodine- 125 radioimmunoassay for serum cortisol in which the interfering binding proteins are inactivated by a combination of reaction pH and 8-anilino-1-naphthalenesulfonic acid. The procedure is easy to perform and gives accurate and reliable results. The shift in pH for optimum binding of an antibody resulting from immobilization on a solid support, used to decrease cortisol binding competition in the present test, is potentially exploitable in other antibody and enzyme systems.
A sequencing and fan-out mechanism for dataflow computing (1991)

A sequencing and data fanout mechanism is provided for a dataflow processor is activated by an input token which causes a sequence of operations to occur by initiating a first instruction to act on data contained within the token and then executing a sequential thread of instructions identified by either a repeat count and an offset within the token, or by an offset within each preceding instruction.
Method and apparatus for controlling to a multiple fuel combustor (1984)

Method and apparatus for controlling the distribution of secondary air (30) between at least two fuel burners (14,16) in a multiple fuel combustor (16). Total chemical energies of the individual fuel streams (44,60) are determined and compared (64,66) with the total combustor chemical energy input (62) for controlling biasing means (32,34). The determination of at least one individual fuel total chemical energy content (60) may optionally include a prompt neutron activation type analyzer (48) for on-line measurement of specific fuel chemical energy (59).
The development of a performance-enhancing additive for vapor-compression heat pumps (1997)

This paper describes the testing results of a vapor-compression heat pump operating with HFC-134a refrigerant and a performance-enhancing additive. Preliminary bench-top testing of this additive, when added to polyolester (POE) lubricant and HFC-134a refrigerant, showed surprising enhancements to system COP. To further investigate this finding, we designed and fabricated a vapor-compression heat pump test stand for the 3-5 ton range. We investigated the effect of different concentrations of this additive on various system performance parameters such as cooling capacity, compressor power requirement, pressure ratio, compressor pressure difference, compressor isentropic efficiency, refrigerant flow rate, and heat exchanger performance. We investigated various heat source and heat sink conditions to simulate air-conditioning and heat pump operating conditions. To investigate the effect of this additive on compressor lubrication and life, we performed compressor life tests (with scroll and reciprocating compressors), and we had lubrication wear tests performed with various concentrations of the additive in the POE lubricant.
Hyperglycosylated Human Chorionic Gonadotropin (Invasive Trophoblast Antigen) Immunoassay: A New Basis for Gestational Down Syndrome Screening (1999)

Hyperglycosylated hCG is a new base marker for Down syndrome screening in the second trimester of pregnancy. The measurement of hyperglycosylated hCG can fundamentally improve the performance of Down syndrome screening protocols.
Tyrosine Kinase Inhibitors. 12. Synthesis and Structure−Activity Relationships for 6-Substituted 4-(Phenylamino)pyrimido[5,4-<i>d</i>]pyrimidines Designed as Inhibitors of the Epidermal Growth Factor Receptor (1997)

A series of 6-substituted 4-anilinopyrimido[5,4-d]pyrimidines has been prepared and shown to be potent inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR). These compounds are structurally related to the pyrido[3,2-d]- and pyrido[3,4-d]-pyrimidines previously shown to be EGFR inhibitors. Their structure-activity relationships (SAR) for inhibition of the isolated enzyme more closely resemble those of the [3,2-d] than the [3,4-d] pyridopyrimidine isomers. This suggests the requirement of an aza atom in the 7- but not the 5-position (i.e., a carbon atom in the 5-position) for the enhanced potency shown by 6-N-methylated derivatives in each series. X-ray crystal structures were determined for the three NHMe derivatives 2, 3, and 5c in the pyrido[9,2-d]-, pyrido[3,4-d]-, and pyrimido[5,4-d]-pyrimidine series, respectively. These show that a carbon rather than a nitrogen atom at the 5-position leads to significant conformational changes in the molecule (a longer C5a-C4 bond and a 30 degrees out-of-plane rotation of the phenyl group), due to the requirement to relieve nonbonding interactions between the C5 and N9 protons. Pyrimido[5,4-d]pyrimidine analogues bearing bulky, weakly basic solubilizing side chains linked to the 6-position through a secondary amine generally retained potency both against the isolated enzyme and for inhibition of autophosphorylation of EGFR in intact A431 cells. This agrees with a recent binding model that suggests this general class of compounds binds to EGFR with the 6-position located in an area of comparative bulk tolerance at the entrance to the ATP-binding pocket. While these solubilized pyrimido[5,4-d]pyrimidine analogues were less potent than the NHMe derivative 5c in the isolated enzyme assay, some were considerably superior to 5c (and among the most potent ever reported) as inhibitors of EGFR autophosphorylation in cellular assays.
Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor (2014)

The EphA4 receptor is highly expressed in the nervous system, and recent findings suggest that its signaling activity hinders neural repair and exacerbates certain neurodegenerative processes. EphA4 has also been implicated in cancer progression. Thus, EphA4 inhibitors represent potential therapeutic leads and useful research tools to elucidate the role of EphA4 in physiology and disease. Here, we report the structure of a cyclic peptide antagonist, APY, in complex with the EphA4 ligand-binding domain (LBD), which represents the first structure of a cyclic peptide bound to a receptor tyrosine kinase. The structure shows that the dodecameric APY efficiently occupies the ephrin ligand-binding pocket of EphA4 and promotes a "closed" conformation of the surrounding loops. Structure-guided relaxation of the strained APY β-turn and amidation of the C terminus to allow an additional intrapeptide hydrogen bond yielded APY-βAla8.am, an improved APY derivative that binds to EphA4 with nanomolar affinity. APY-βAla8.am potently inhibits ephrin-induced EphA4 activation in cells and EphA4-dependent neuronal growth cone collapse, while retaining high selectivity for EphA4. The two crystal structures of APY and APY-βAla8.am bound to EphA4, in conjunction with secondary phage display screens, highlighted peptide residues that are essential for EphA4 binding as well as residues that can be modified. Thus, the APY scaffold represents an exciting prototype, particularly since cyclic peptides have potentially favorable metabolic stability and are emerging as an important class of molecules for disruption of protein-protein interactions.
Anti-Parallel Coupled Soft Under Layers for High-Density Perpendicular Recording (2004)

A promising soft magnetic under layer (SUL) structure consisting of anti-parallel coupled soft layers (APS) is investigated to improve the performance of high-density perpendicular recording media. CoCrPt-O recording media with average grain diameter /spl sim/6 nm, coercivity of 5 kOe and nucleation field of -2 kOe is fabricated on both conventional SUL and APS. Wide-area adjacent track erasure (ATE) is observed for conventional SUL, which increases at lower interlayer spacing (t/sub IL/). APS structure enables the suppression of ATE even up to t/sub IL/=10 nm. Moreover, APS leads to reduced dc erase noise and improved signal to noise ratio particularly for SUL thicknesses <100 nm.
Expression and Characterization of Pro α2-Plasmin Inhibitor (1989)

alpha s-Plasmin inhibitor (alpha 2PI), one of the serine protease inhibitors in plasma, was expressed in baby hamster kidney (BHK) cell line. The expression vector was constructed with its genomic DNA and cDNA, and was transfected into BHK cells by the calcium phosphate method. The recombinant alpha 2PI which was secreted from the cells was estimated by SDS-PAGE to have a molecular mass of 67 kDa, which is indistinguishable from that of normal plasma alpha 2PI. The leader peptide of 12 amino acids was retained at the amino terminus of the recombinant alpha 2PI. This finding suggests that alpha 2PI has pre-pro type processing and the propeptide of 12 amino acids is not removed in BHK cells. This pro-alpha 2PI shows essentially the same inhibitory activity on plasmin and the same affinity for plasmin(ogen) as those of normal alpha 2PI. However, the cross-linking ability to fibrin is reduced to less than one-third of that of normal alpha 2PI. The cross-linking site is the glutamine residue located at the second position from the amino terminus of normal alpha 2PI. The conformational change of this region caused by the addition of the propeptide may have affected the cross-linking capacity of the inhibitor.
Acoustic methods for classification of fluids in sealed containers for identification of hazardous chemicals (1999)

There are many situations where it is necessary to be able to determine information about the liquid contents inside sealed or otherwise inaccessible containers. Typically for classification of a liquid filler, one needs to determine some simple properties of the liquid contents, such as the sound speed, density, and attenuation of the liquid. This information is often sufficient to identify and characterize various subclasses of chemicals. In cases where the containers are to contain hazardous chemicals (e.g., chemical warfare agents, highly toxic chemicals, highly flammable liquids, etc.) it may be unsafe for operators to make measurements using traditional techniques which require direct contact with the contents. This talk will address several techniques which address fluid classification for situations where direct contact with the fluid is not feasible. It will concentrate on methods which couple acoustic energy into the interior container cavity (by means of direct contact or stand-off methods) to extract frequency dependent acoustic information to serve as classification clues to identify the filler.
Control of the Amount of Free Molecular Iodine in Iodine Germicides (1997)

Horseradish peroxidase has been used to generate iodine compositions that comprised principally free molecular iodine. The concentration of free molecular iodine in these enzyme-based compositions ranged from 44 to 63% of the thiosulphate titratable iodine; this is substantially higher than the corresponding value for the povidone-iodine preparation betadine. The biocidal efficacy of these compositions was proportional to the concentration of free molecular iodine. Iodine compositions with relatively low total iodine concentrations but high levels of free molecular iodine (20-175 ppm) killed Staphylococcus aureus and spores of Bacillus subtilis more rapidly than betadine. The effects of normal saline and these enzyme-based iodine compositions on the rate of epidermal regeneration in superficial swine wounds were comparable. These results suggest that an effective germicide containing a high level of molecular iodine need not be irritating or toxic.