gebhart/patrepeval huggingface dataset:
Skeletal muscle‐specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21‐mediated non‐cell‐autonomous energy metabolism (2015)

The eukaryotic translation initiation factor 2α (eIF2α) phosphorylation-dependent integrated stress response (ISR), a component of the unfolded protein response, has long been known to regulate intermediary metabolism, but the details are poorly worked out. We report that profiling of mRNAs of transgenic mice harboring a ligand-activated skeletal muscle-specific derivative of the eIF2α protein kinase R-like ER kinase revealed the expected up-regulation of genes involved in amino acid biosynthesis and transport but also uncovered the induced expression and secretion of a myokine, fibroblast growth factor 21 (FGF21), that stimulates energy consumption and prevents obesity. The link between the ISR and FGF21 expression was further reinforced by the identification of a small-molecule ISR activator that promoted Fgf21 expression in cell-based screens and by implication of the ISR-inducible activating transcription factor 4 in the process. Our findings establish that eIF2α phosphorylation regulates not only cell-autonomous proteostasis and amino acid metabolism, but also affects non-cell-autonomous metabolic regulation by induced expression of a potent myokine.
The monocyte-derived neutrophil activating peptide (NAP/interleukin 8) stimulates human neutrophil arachidonate-5-lipoxygenase, but not the release of cellular arachidonate. (1989)

LPS and mitogen-stimulated mononuclear cells secrete a cytokine, which is able to activate the PMNL-arachidonate-5-lipoxygenase. This cytokine has been proven to be identical with the recently characterized novel neutrophil-activating peptide NAP/IL-8. NAP/IL-8 is able to activate human PMNL for release of LTB4, omega-oxidized LTB4, and 5-HETE in the presence of exogenous AA. Half-maximal concentration of NAP/IL-8 for release of LTB4 has been found to be near 4 x 10(-8) mol/liter. Time course studies revealed rapid activation of PMNL, with maximal release of LTB4 within the first 10 min with a decline up to 40 min. High amounts of omega-oxidized LTB4 were detected up to that time. Significant amounts of AA-5-LO-products can be detected only when PMNL were stimulated with NAP/IL-8 in the presence of exogenous AA. The concentration of AA necessary for half-maximal LTB4 release has been found to be 3 x 10(-6) mol/liter. In the presence of 8 x 10(-9) mol/liter [3H]AA, NAP/IL-8 (10(-9) to 10(-7) mol/liter) did not induce the production of LTB4, omega-oxidized LTB4, or 5-HETE. In addition, PMNL prelabeled with [3H]AA did not release either [3H]AA or 5-lipoxygenase metabolites when stimulated with NAP/IL-8 (10(-9) to 10(-7) mol/liter), indicating that NAP/IL-8 apparently does not activate cellular phospholipases/diacylglycerol-lipases. Apart from FMLP, C5a, and PAF NAP/IL-8 is the fourth clearly characterized neutrophil chemotaxin able to activate the PMNL-5-lipoxygenase. The detection of large amounts of NAP/IL-8, arachidonic acid, as well as LTB4-like material, in lesional material of patients with psoriasis points towards a possibly important role of NAP/IL-8 in amplifying inflammatory processes by induction of LTB4-production.
Student and Teacher Attitudes Toward Giftedness in a Two Laboratory School Environment: A Case for Conducting a Needs Assessment (2013)

Providing effective professional development in laboratory schools around topics that can be divisive, such as preparing a school environment for expansion of gifted education services, can be quite difficult. However, doing so based on data collected through a needs assessment can be invaluable to the planning process. As part of a needs assessment in preparation to enroll 100 new gifted students, students and teachers (N=171) from a unique setting in which a residential school for gifted high school students is housed within a laboratory school were surveyed using F. Gagné and L. Nadeau’s (1991) Opinions about the Gifted and Their Education instrument. Clustering participants based on their responses identified 3 distinct clusters showing varied support for gifted education. Most laboratory school students and teachers opposed special services for gifted students. A group of supporters, made up of some laboratory school and residential school teachers and approximately a third of residential school students acknowledged the needs and social value of gifted students to some degree and strongly supported gifted education. Most students in the residential school (59%) were conflicted, recognizing the needs of gifted students and the value of giftedness, but showing opposition to gifted education. In addition to its usefulness in designing effective professional development, the needs assessment identified attitudes that have implications for the larger gifted education community.
The Ecto-5’-Nucleotidase/CD73 Inhibitor, α,β-Methylene Adenosine 5’-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat (2019)

The ecto-5'-nucleotidase (ecto-5’NT/CD73) represents a crucial enzyme for endogenous adenosine generation. Several findings have shown that CD73 plays an important role in regulating vascular permeability and immune cell function. Adenosine 5'-(α,β-methylene) diphosphate (APCP) is a CD73 inhibitor, widely used as pharmacological tool to investigate the role of CD73/adenosine pathway in several in vitro and in vivo models, although it has been also shown to inhibit other ectoenzymes involved in adenosinergic pathway. Here, we evaluated the effect of APCP in the development of inflammation in carrageenan-induced pleurisy model. We found that treatment with APCP (400 μg/rat) significantly increased cell accumulation, exudate formation and pro-inflammatory cytokine content into the pleural cavity in the acute phase (4 h) of inflammation, with no differences in the sub-acute phase (72 h) except for the regulation of monocyte chemotactic protein-1 levels. In addition, cells collected by pleural lavage fluids of APCP - treated rats, 4 hours following carrageenan injection, showed increased ability to migrate in vitro, both in presence and in absence of N-formyl-L-methionyl-L-leucyl-L-phenylalanine as chemotactic stimulus, compared to cells obtained by control rats. Our results demonstrate that APCP exacerbates the early phase of carrageenan-induced pleurisy by controlling pleural effusion and polymorphonuclear migration in vivo and ex vivo. This effect is likely dependent upon CD73 inhibition, although an inhibitory effect of other ectoenzymes cannot be ruled out.
Orality (2020)

Academic debates concerning orality have hinged on whether to focus on abstract structural features of oral language and oral performances, particularly in contrast to written language, or whether to address the social complexities of diverse local forms and their uses. The contributions of researchers who advocated for universal characteristics with broad social and psychological implications have been influential, but their generalizations have been questioned by researchers seeking to convey local cultural dynamics and ideologies, and by scholars seeking to broaden the frameworks of discussion.
Dehydration characteristics of Magnesium Chloride Hydrate (2007)

Anhydrous magnesium chloride, dehydration product from magnesium chloride hydrate is a general raw material to prepare electrolytic magnesium. However, the dehydration is not trivial and can be accompanied by hydrolysis leading to the production of undesirable hydroxy chloride compounds of magnesium. Therefore, dehydration process is actually the most complicated and hardest in the electrolysis methods for the production of magnesium. In this work, the influence of dehydrating temperature has been studied at the temperature range from to in air and HCl gas atmosphere individually to compare the results. With increasing of dehydration temperature MgOHCl and MgO were obtained in air. On the other hand, when the temperature was increased above anhydrous magnesium chlorides were prepared in HCl gas atmosphere. Anhydrous magnesium chloride was formed at near and completely crystallized at about . All of the HCl used as atmosphere gas in the dehydration was recovered as hydrochloric acid solution at a water vessel up to 41% by weight at .
Reciprocal Antagonism Between Estrogen Receptor and NF-κB Activity In Vivo (2001)

The functional interaction, or "cross-talk," between estrogen receptor (ER) and the proinflammatory transcription factor nuclear factor (NF)-kappaB demonstrated in vitro has been suggested to play a role in estrogen prevention of cardiovascular disease. Here, we demonstrate that this reciprocal cross-talk occurs in vivo. Ovariectomized C57BL/6 mice fed an atherogenic diet had increased hepatic levels of active NF-kappaB and numerous inflammatory genes, including MHC invariant chain (Ii), vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and RANTES. Treatment with 17alpha-ethinylestradiol (EE) strongly blocked induction of these genes but had no effect on their basal expression levels. ER was required for this activity, because the antagonist ICI 182,780 completely blocked the inhibitory activity of EE. Gene activation by EE was not required for inhibition of inflammatory gene expression, because both the phytoestrogen genistein and low doses of EE were effective in blocking inflammatory gene induction without inducing marker genes such as intestinal trefoil factor (ITF) or myo-inositol-1-phosphate synthase (IPS). The in vivo transcriptional interference was reciprocal, with EE induction of ITF and IPS greatly reduced in animals fed the atherogenic diet versus chow-fed controls. This interference was specific to the liver, because diet had no effect on uterine weight increases produced by EE. Transfection experiments confirmed that the extent of inhibition of ER-mediated transcription by inflammatory stimuli correlated with the extent of NF-kappaB activation. These results suggest that the cross-talk between ER and NF-kappaB does occur in vivo and may indeed contribute significantly to the cardioprotective effects of estrogen.
ChemInform Abstract: Retinoid X Receptor‐Antagonistic Diazepinylbenzoic Acids. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Learning Non-Linear Combinations of Kernels (2009)

This paper studies the general problem of learning kernels based on a polynomial combination of base kernels. We analyze this problem in the case of regression and the kernel ridge regression algorithm. We examine the corresponding learning kernel optimization problem, show how that minimax problem can be reduced to a simpler minimization problem, and prove that the global solution of this problem always lies on the boundary. We give a projection-based gradient descent algo-rithm for solving the optimization problem, shown empirically to converge in few iterations. Finally, we report the results of extensive experiments with this algo-rithm using several publicly available datasets demonstrating the effectiveness of our technique. 1
Polydopamine Wrapping Silicon Cross-linked with Polyacrylic Acid as High-Performance Anode for Lithium-Ion Batteries (2016)

A robust silicon electrode for lithium-ion battery has been developed via prepolymerizing dopamine on silicon particle surface and then chemical binding with poly(acrylic acid) (PAA). In this favorable electrode, silicon nanoparticles are covered by a thin layer of polydopamine (PD) through firm hydrogen bonds between phenolic hydroxyl and hydroxyl, while the elastic polymer layer reacts with PAA binder to form three-dimensional cross-linked binding system. The Si@PD/PAA electrode exhibits more stable cycle performance than conventional electrodes. In the case of thick electrode, a capacity of 3.69 mA h cm(-2) and fairly good rechargeability for 80 cycles can be achieved.
Stepwise transannular bond formation between the bridgehead atoms in Z-P(MeNCH2CH2)3N systems (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStepwise transannular bond formation between the bridgehead atoms in Z-P(MeNCH2CH2)3N systemsJ. S. Tang, M. A. H. Laramay, V. Young, S. Ringrose, R. A. Jacobson, and J. G. VerkadeCite this: J. Am. Chem. Soc. 1992, 114, 8, 3129–3131Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/ja00034a065https://doi.org/10.1021/ja00034a065research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Epigenetic modification of PKMζ rescues aging-related cognitive impairment (2016)

Cognition is impacted by aging. However, the mechanisms that underlie aging-associated cognitive impairment are unclear. Here we showed that cognitive decline in aged rats was associated with changes in DNA methylation of protein kinase Mζ (PKMζ) in the prelimbic cortex (PrL). PKMζ is a crucial molecule involved in the maintenance of long-term memory. Using different behavioral models, we confirmed that aged rats exhibited cognitive impairment in memory retention test 24 h after training, and overexpression of PKMζ in the PrL rescued cognitive impairment in aged rats. After fear conditioning, the protein levels of PKMζ and the membrane expression of GluR2 increased in the PrL in young and adult rats but not in aged rats, and the levels of methylated PKMζ DNA in the PrL decreased in all age groups, whereas the levels of unmethylated PKMζ DNA increased only in young and adult rats. We also found that environmentally enriched housing reversed the hypermethylation of PKMζ and restored cognitive performance in aged rats. Inactivation of PKMζ prevented the potentiating effects of environmental enrichment on memory retention in aged rats. These results indicated that PKMζ might be a potential target for the treatment of aging-related cognitive impairment, suggesting a potential therapeutic avenue.
Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP+ and Rotenone Toxicity (2016)

The G-protein coupled receptor 139 (GPR139) is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. Here, we examined the potential neuroprotective effect of GPR139 agonism in primary culture models of dopaminergic (DA) neuronal degeneration. We find that in vitro GPR139 agonists protected primary mesencephalic DA neurons against 1-methyl-4-phenylpyridinium (MPP(+))-mediated degeneration. Protection was concentration-dependent and could be blocked by a GPR139 antagonist. However, the protection of DA neurons was not found against rotenone or 6-hydroxydopamine (6-OHDA) mediated degeneration. Our results support differential mechanisms of toxicity for those substances commonly used in Parkinson's disease (PD) models and potential for GPR139 agonists in neuroprotection.
Stabilize an Unsupervised Feature Learning for LiDAR-based Place Recognition (2018)

Place recognition is one of the major challenges for the LiDAR-based effective localization and mapping task. Traditional methods are usually relying on geometry matching to achieve place recognition, where a global geometry map need to be restored. In this paper, we accomplish the place recognition task based on an end-to-end feature learning framework with the LiDAR inputs. This method consists of two core modules, a dynamic octree mapping module that generates local 2D maps with the consideration of the robot's motion; and an unsupervised place feature learning module which is an improved adversarial feature learning network with additional assistance for the long-term place recognition requirement. More specially, in place feature learning, we present an additional Generative Adversarial Network with a designed Conditional Entropy Reduction module to stabilize the feature learning process in an unsupervised manner. We evaluate the proposed method on the Kitti dataset and North Campus Long-Term LiDAR dataset. Experimental results show that the proposed method outperforms state-of-the-art in place recognition tasks under long-term applications. What's more, the feature size and inference efficiency in the proposed method are applicable in real-time performance on practical robotic platforms.
Names for mycobacteria. (1984)

To the founding fathers of bacteriology the nomenclature of pathogens was straightforward. Tuberculosis was caused by the tubercle bacillus and leprosy was caused by the leprosy bacillus and when these pathogens were allocated to the genus Myco bacteriwn this posed no problem, they merely became M tuberculosis and M leprae. This golden age of simplicity in nomenclature was, however, short lived as it soon became apparent that tubercle bacilli were not all identical and that some tuberculosis-like infections were caused by other myco bacterial species that normally existed as saprophytes in the inanimate environment. In our experience mycobacterial nomenclature is a frequent source of confusion to physicians and we will thus attempt to shed some light on this subject.
Single-Cycle LCL-T Resonant Converter for Solar Battery (2018)

In this paper we consider single-cycle solar battery energy converter with resonant LCL-T circuit. It is shown that the using LCL-T converter allows to get in wide load range stabilized voltage from solar battery which is a current source. Besides, single-cycle mode allows excluding transformer from converter circuit and simplifying the topology, but increasing the resonant circuit current.
Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway. (2003)

Prostaglandin (PG) E(2), a cyclooxygenase (COX) product, and angiotensin II are endogenous and have physiological roles in the body. On the other hand, an inducible isoform of COX (COX-2), insulin-like growth factor (IGF) II, and IGF-I receptor (IGF-IR) are up-regulated in colon carcinoma and might have crucial roles in tumor growth and invasion. The aim of the present study was to investigate the effects of COX-2 inhibitor and drugs blocking the biological activities of angiotensin II [angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs)] on IGF-IR expression and tumor growth in vivo. We also investigated the effects of PGE(2), a major COX-2 product, in cancer cells and the effects of angiotensin II on IGF-IR expression and the underlying mechanism of action. In in vivo studies, tumor growth and IGF-IR expression were investigated in Colon 26 cells inoculated into BALB/c mice. In in vitro studies, the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on IGF-IR expression were analyzed in three colon cancer cell lines (Colon 26, HCA-7, and LS174T). IGF-II-induced cell growth and invasion were analyzed in Colon 26 cells in the presence and absence of NSAIDs (indomethacin and celecoxib) and angiotensin II. Celecoxib at the lowest effective dose for suppression of PG production (3 mg/kg) or an ACE inhibitor/ARB alone did not have a significant effect as compared with controls, although a high dose of celecoxib (>20 mg/kg) suppressed tumor growth. On the other hand, combination therapy with these two categories of drugs significantly reduced tumor growth in vivo. Treatment with both celecoxib and an ACE inhibitor/ARB decreased IGF-IR expression levels in inoculated tumor cells. In in vitro studies, NSAIDs reduced IGF-IR expression in a dose-dependent manner in all three cell lines. NSAIDs also inhibited IGF-II-stimulated growth and invasion in a dose-dependent manner. PGE(2) or angiotensin II treatment reversed the NSAID-induced down-regulation of IGF-IR expression, growth, and invasion. PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway. Thus, combination therapy with NSAIDs and ACE inhibitors targeting IGF-IR might be a novel and potentially promising strategy for the chemoprevention of colon cancer.