gebhart/patrepeval huggingface dataset:
Performance assessment of a 3-body self-reacting point absorber type wave energy converter (2019)

The Variable Inertia System Wave Energy Converter (VISWEC) is a self-reacting point absorber (SRPA) type wave energy converter (WEC) capable of changing its mechanical impedance using an internal reaction mass system. The reaction mass is coupled to a rotating assembly capable of varying its inertia and this changing inertia has the effect of creating an added inertial resistance, or effective mass, to oscillations of the reaction mass. An SRPA has two main bodies, designated Float and Spar, capable of utilizing the relative motion between the two bodies to create power through a power take-off (PTO). The implementation of the reaction mass, a 3rd body, and the variable inertial system (VIS) is designed to change the response of the Spar in order to create larger relative velocities between the two bodies and thus more power. It is also possible to lock the VIS within the Spar, and when this is done the system is reduced to a conventional 2-body SRPA configuration. \nTo better understand the effects of the implementation of the VIS on the overall stability of the VISWEC and the power conversion performance, a numerical model simulation within ProteusDS, a time-domain modelling software, was created. Power production and parametric excitation are the metrics of comparison between the two systems. Parametric excitation is a phenomenon that correlates wave excitation frequency to roll stability and has been shown to negatively affect power production in SRPAs. Simulations of the 2 and 3-body provide a basis of comparison between the two systems and allow the assessment of parametric excitation prohibited or exacerbated by the implementation of the VIS as well as power production.\nThe simulation executed within the commercial software ProteusDS incorporates articulated bodies defined with physical parameters connected through connections allowing kinematic constraints and relations and hydrodynamics of the hull geometries as they are exposed to regular waves. ProteusDS also has the ability to apply kinematic constrains on the entire system allowing the analysis of isolated modes of motion.\nThe implementation of the VIS demonstrates a generally higher power production and stabilization of the system with regards to parametric excitation. While the 3-body system is more stable, the bandwidth at which rolling motion is induced increased in comparison to the 2-body system. Rolling motions in both the 2 and 3-body systems are characteristic of parametric excitation and show a direct correlation to reduced power production. Overall the 3-body VISWEC outperforms the typical 2-body SRPA representation but more research is required to refine the settings of the geometric and PTO control.
Mapeamento de genes de resistência à ferrugem e de QTLs envolvidos na resistência à septoriose em soja (2005)

\n A ocorrência de doenças em soja tem aumentado nos últimos anos, provocando grandes perdas em plantios comerciais e exigindo respostas rápidas da pesquisa para desenvolvimento e aplicação de técnicas de controle. Mais de 40 doenças afetam a cultura da soja em todo o mundo e dentre elas estão a ferrugem asiática (Phakopsora pachyrhizi Sydow) e a septoriose ou mancha parda (Septoria glycines Hemmi). Estas doenças estão disseminadas em praticamente todas as regiões produtoras de soja do Brasil. Os objetivos desse trabalho foram mapear o gene que confere resistência a P. pachyrhizi presente na cultivar de soja FT-2 e QTLs envolvidos na resistência a S. glycines, utilizando uma população de plantas F2 derivada do cruzamento entre as cultivares FT-2 (resistente) e Davis (suscetível). Marcadores microssatélites foram testados nos genitores, sendo os polimórficos utilizados para genotipar as plantas da geração F2. Progênies F3:2 e F4:2 foram obtidas e avaliadas para reação às doenças. Para a ferrugem da soja foram detectados cinco marcadores associados ao caráter, sendo que dois deles (Satt079 e Satt307) flanqueiam o gene dominante de resistência, que foi mapeado no grupo de ligação C2 da soja. Uma eficiência de seleção de 100% foi obtida com o uso simultâneo destes dois últimos marcadores, indicando que os mesmos podem ser ferramentas úteis para a seleção assistida de genótipos homozigóticos resistentes. Para a mancha parda, análises de regressão e de variância foram realizadas para identificar associações significativas entre marcadores e QTLs devido a efeitos aditivos e não aditivos do caráter. Foi realizado, também, o mapeamento por intervalo dos QTLs. As análises de regressão detectaram maior número de marcadores ligados a QTLs do que o mapeamento por intervalo; houve concordância entre os resultados dos dois métodos em apenas um caso, no qual o marcador Satt277, pertencente ao grupo de ligação C2, foi relacionado significativamente ao caráter.\n
Plan execution monitoring with distributed intelligent agents for battle command (2004)

As military tactics evolve toward execution centric operations the ability to analyze vast amounts of mission relevant data is essential to command and control decision making. To maintain operational tempo and achieve information superiority we have developed Vigilant Advisor, a mobile agent-based distributed Plan Execution Monitoring system. It provides military commanders with continuous contingency monitoring tailored to their preferences while overcoming the network bandwidth problem often associated with traditional remote data querying. This paper presents an overview of Plan Execution Monitoring as well as a detailed view of the Vigilant Advisor system including key features and statistical analysis of resource savings provided by its mobile agent-based approach.
Tatimma Issue 3 (2011)

Memory as an instrument for peace, reconciliation and common living.
Hydrology of Hope (2010)

The process of appropriation moves from diffidence to entitlement — and sometimes back again. At first, settlers and colonizers ask themselves, "Do we belong here?" Over time, such doubt may dissipate — as it did in the United States. That country occupies an extreme position among territories colonized from overseas. Whites achieved demographic, political, and economic dominance, securing the United States as a "neo-Europe" (Crosby 1986:2). Zimbabwe lies at the other extreme — among what one might call failed neo-Europes. Having conquered the territory in the 1890s and alienated the fertile highveld in ensuing decades, whites never approached numerical superiority vis-à-vis native peoples. Stuck in this "demographic conjucture," whites' population never exceeded 5 percent of the national total.1 In agriculture, at the end of the twentieth century, almost 4,500 families of white commercial farmers controlled roughly 33 percent of Zimbabwe'ssurface area — in a nation of 12 million (Figure 4.1). Whites then had reason to feel what Wagner (1994:171) describes, in South Africa, as an "emotional and moral unease with the fruits of conquest." Still, white farmers, who mostly survived an incomplete land reform in the early 1980s, displayed an almost Euro-American degree of confidence — one totally unwarranted by political trends.2 In the 1990s, whites ignored warnings of a more thorough land reform. In 2000, when paramilitary bands occupied their land, farm owners reacted with shock and disbelief. Unprotected by the police and frequently barricaded in their houses, they still felt that they belonged, as owners, on the high veld. How could they — indeed, how could any European-derived minority — develop such a resilient claim to extra-European territory?KeywordsCommercial FarmerLand ReformFarm OwnerAnnual General MeetingReturn ChannelThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The determination of the optical constants of thin films from measurements of reflectance and transmittance at normal incidence (1972)

The derivation of the components n and k of the complex refractive index of a thin film from measurements, at normal incidence, of reflectance R and transmittance T is complicated by the existence of multiple solutions of the relevant equations. It is shown that, although use of Tomlin's expressions for (1 ± R )/ T rather than Heavens's explicit formulae for R and T separately simplifies the problem, it is still necessary to consider very carefully the multiple solutions. A procedure is given for determining the correct solutions for n and k , and also for accurately fixing the film thickness, provided that the film is a homogeneous single layer on a substrate. Some experimental results have not yielded to this treatment and in these cases it has been found necessary to assume the presence of a surface layer (often, but not necessarily, an oxide layer) and to make use of the equations in the preceding paper which relate to a double layer on a substrate. It is shown how this may be done in such a way as to obtain the correct dispersion curve for the material, together with its thickness, and that of the surface layer.
The immunobiology of apotransferrin in type 1 diabetes (2012)

The transferrin (Tf) family of iron binding proteins includes important endogenous modulators of the immune function that may modulate autoimmune diseases. To define more clearly the role of apotransferrin (apoTf) in type 1 diabetes we determined the impact of this protein on type 1 diabetes as investigated in islet cells, animal models and patient sera. First, we demonstrated that recombinant apoTf counteracts the cytokine-induced death of murine pancreatic islet cells. Secondly, human apoTf administration favourably influences the course of type 1 diabetes in animal models, resulting in protection against disease development that was associated with reduction of insulitis and reduced levels of proinflammatory cytokines. Finally, we confirmed that patients with newly diagnosed type 1 diabetes manifest significantly lower apoTf serum levels compared to healthy controls and patients with long-lasting disease. In conclusion, our data suggest the apoTf pivotal role in the perpetuation of type 1 diabetes pathology.
Probucol attenuates the development of aortic atherosclerosis in cholesterol‐fed rabbits (1989)

1. Probucol was administered to rabbits fed a cholesterol-enriched (2% wt/wt) diet to determine potential anti-atherogenic effects in a preparation in which the disease process is due to elevated plasma concentrations of cholesterol ester-rich very low density lipoproteins (CER-VLDL). 2. Probucol was supplemented to the diet at 1% wt/wt which resulted in plasma concentrations rising steadily to 53 +/- 8 micrograms ml-1 after 14 days, with no significant changes during continued administration. Dietary consumption and body weight gains were comparable in the drug-treated and control groups during the observation period. 3. Probucol treatment did not significantly affect plasma concentrations of total cholesterol, unesterified cholesterol, triglycerides or phospholipids. 4. The concentration of CER-VLDL in plasma and its physicochemical characteristics were not significantly changed during administration of probucol. CER-VLDL from both control and probucol-treated animals was a potent stimulant of the augmentation of the intracellular incorporation of [3H]-oleate into cholesteryl-[3H]-oleate in cultured macrophages. 5. Despite the lack of effect of probucol on concentrations of plasma lipids and the cell interaction characteristics of CER-VLDL, administration of the drug markedly decreased the extent of intimal aortic surface area covered by grossly discernible atherosclerotic lesions from 55.6 +/- 11.8% to 11.6 +/- 1.9% in thoracic sections, and from 49.1 +/- 10.2% to 7.2 +/- 0.4% in abdominal sections. Furthermore, probucol treatment significantly reduced the deposition of total cholesterol in vascular tissue. 6. Probucol reduced the extent of aortic atherosclerosis produced by diet-induced hypercholesterolemia in rabbits. This reduction occurred in the absence of any significant change in the characteristics of plasma lipoproteins that were determined. These results indicate that either there is a role of oxidation in the disease process of this animal model of atherosclerosis or that probucol is acting via a presently undefined mechanism.
A VLSI for deskewing and fault tolerance in LVDS links (2005)

The device presented at this work is a switch implemented in a 0.35 mum CMOS process for compensating the skew which affects parallel data signal transmissions and for providing fault tolerance in large scale scalable systems, for instance used in trigger farms for high energy physics experiments. The SWIFT chip (SWItch for Fault Tolerance) is part of a cluster built around commercially components which has been inspired by the LHCb experiment. The skew is extremely important because it directly affects the sample window available to the receiver logic and either forces to use quality and expensive cables in order to minimize its effects or reduces the maximum signal transmission range or distance. This problem is handled by the deskewing circuitry at the SWIFT chip, which is able to match dynamically the signal transitions at the receiver link by adding an individual delay to each input signal in steps of 100 ps for LVDS signals up to 250 MHz. The deskew module is based on full custom analog delay units plus a digital skew detector block. A 16-bit processor is implemented for processing tasks. The chip compensates dynamically skews of LVDS signals up to 250 MHz in steps of 100 ps and adds fault tolerance to the farm of PCs by allowing the bypassing of a failing compute node to which is attached
The Sensation And Regulation Of Interactions With The Extracellular Environment: The Cell Biology Of Lymphocyte Adhesion Receptors (1990)

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
Research and Development (1979)

The purpose of this chapter is to consider in detail the factors which should influence the investment of a firm in research and development (R & D). A brief introductory section considers the relationship of such expenditure to the strategic planning of the firm. Subsequently a number of problems peculiar to R & D are elicited and certain principles emerge. The R & D process is then considered in more specific terms and particular attention is directed to classification and evaluation procedures. Consistency in the evaluation procedures, at varying points in time, is emphasised and the use of alternative models to facilitate this objective is discussed.
Single Exposure to Heat Induces Stage-Specific Germ Cell Apoptosis in Rats: Role of Intratesticular Testosterone on Stage Specificity (1999)

Short term exposure of the testis to heat causes degeneration of germ cells. However, the mechanisms underlying this process are poorly understood. The major objectives of this study were to determine whether the heat-induced loss of germ cells in the adult rat occurs via apoptosis, to document its stage-specific and cell-specific distribution, and to examine whether intratesticular testosterone (T) plays any role in the stage specificity of heat-induced germ cell death. Testes of adult male Sprague-Dawley rats were exposed to 22 C (control) or 43 C for 15 min. Animals were killed on days 1, 2, 9, and 56 after heat exposure. Germ cell apoptosis was characterized by DNA gel electrophoresis and in situ terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick end labeling assay. The incidence of germ cell apoptosis [apoptotic index (AI)] was quite low in control rats (AI = 0.04–0.1). Mild hyperthermia within 1 or 2 days resulted in a marked activation (AI = 4.7–5.6) of germ cell apoptosis predominantly at early (I–IV) and late (XII–XIV) stages. Stages V–VI and VII–VIII were relatively protected from heat-induced apoptosis. Spermatocytes, including pachytenes at stages I–IV and IX–XII, diplotene and dividing spermatocytes at stages XIII–XIV, and early (steps 1–4) spermatids, were most susceptible to heat. On day 9, the majority of the tubules were severely damaged and displayed only a few remaining apoptotic germ cells. By day 56, spermatogenesis was completely recovered, and the incidence of germ cell apoptosis was compatible with the control levels. To determine whether intratesticular T plays a role in protecting germ cells at stages VII–VIII against heat-induced cell death, adult rats were exposed to local testicular heating on day 2 or were given a daily sc injection of GnRH antagonist (GnRH-A) for 4 days with and without a single exposure of testes to heat applied on day 2. By day 4, the incidence of increased germ cell apoptosis at stages other than VII–VIII were not different between heat-treated and GnRH-A- plus heat-treated groups, whereas the control group and the group treated with GnRH-A alone showed minimal apoptosis. GnRH-A addition to heat resulted in a further increase in apoptosis (by 3.2-fold) at stages VII–VIII over the values measured in the heat-treated group, and it became comparable to that at all other stages. Collectively, these results provide evidence that 1) heat induces germ cell apoptosis in a stage-specific and cell-specific fashion; and 2) intratesticular T plays a pivotal role in protecting germ cells at stages VII–VIII against heat-induced cell death. However, the possible involvement of various other factors, including growth factors, thermoprotectants, cytokines, and various death-related proteins, in protecting germ cells against heat-induced apoptosis cannot be ruled out.
Loss of Receptor Protein Tyrosine Phosphatase β/ζ (RPTPβ/ζ) Promotes Prostate Cancer Metastasis (2012)

Boosting RPTPβ/ζ or attenuating Syndecan-3 signaling pathways may lead to more effective therapeutic strategies in treating prostate cancer metastasis. Pleiotrophin is a growth factor that induces carcinogenesis. Despite the fact that many published reports focused on the role of pleiotrophin and its receptors, receptor protein tyrosine phosphatase (RPTPβ/ζ), and syndecan-3 during tumor development, no information is available regarding their function in tumor metastasis. To investigate the mechanism through which pleiotrophin regulates tumor metastasis, we used two different prostate carcinoma cell lines, DU145 and PC3, in which the expression of RPTPβ/ζ or syndecan-3 was down-regulated by the RNAi technology. The loss of RPTPβ/ζ expression initiated epithelial-to-mesenchymal transition (EMT) and increased the ability of the cells to migrate and invade. Importantly, the loss of RPTPβ/ζ expression increased metastasis in nude mice in an experimental metastasis assay. We also demonstrate that RPTPβ/ζ counterbalanced the pleiotrophin-mediated syndecan-3 pathway. While the inhibition of syndecan-3 expression inhibited the pleiotrophin-mediated cell migration and attachment through the Src and Fak pathway, the inhibition of RPTPβ/ζ expression increased pleiotrophin-mediated migration and attachment through an interaction with Src and the subsequent activation of a signal transduction pathway involving Fak, Pten, and Erk1/2. Taken together, these results suggest that the loss of RPTPβ/ζ may contribute to the metastasis of prostate cancer cells by inducing EMT and promoting pleiotrophin activity through the syndecan-3 pathway.
β-Galactosidase from Kluyveromyces lactis: Characterization, production, immobilization and applications - A review (2021)

A review on the enzyme β-galactosidase from Kluyveromyces lactis is presented, from the perspective of its structure and mechanisms of action, the main catalyzed reactions, the key factors influencing its activity, and selectivity, as well as the main techniques used for improving the biocatalyst functionality. Particular attention was given to the discussion of hydrolysis, transglycosylation, and galactosylation reactions, which are commonly mediated by this enzyme. In addition, the products generated from these processes were highlighted. Finally, biocatalyst improvement techniques are also discussed, such as enzyme immobilization and protein engineering. On these topics, the most recent immobilization strategies are presented, emphasizing processes that not only allow the recovery of the biocatalyst but also deliver enzymes that show better resistance to high temperatures, chemicals, and inhibitors. In addition, genetic engineering techniques to improve the catalytic properties of the β-galactosidases were reported. This review gathers information to allow the development of biocatalysts based on the β-galactosidase enzyme from K. lactis, aiming to improve existing bioprocesses or develop new ones.
Epidural catheters (1993)

A postal survey of all maternity units in the United Kingdom was conducted to gain information regarding policies for epidural analgesia for labour. The average epidural rate was 19.7% and 78% of units offered a 24-h service. The majority of units inserted the epidural with the patient in the lateral position, using a midline approach, with loss of resistance to air and saline being used almost equally. Most units used 3 ml of 0.5% bupivacaine as a test dose, and only 10% of units used adrenaline in the test dose. The use of adrenaline in subsequent top-ups was infrequent. Bupivacaine 0.5% was used most frequently for the initial and the second stage top-up, whereas 0.25% was most often used during the first stage of labour. Midwife top-ups were allowed in 75% of units and in only 14% of cases was this from a local anaesthetic reservoir. Epidural analgesia using a continuous infusion of anaesthetic was routinely used in 28% of units, mostly with 0.125% bupivacaine; about half of these units did so because midwives were unable to perform top-ups. Routine use of epidural opioids was most frequent when anaesthetic infusions were used, otherwise it was uncommon.
Associations Between Chromosomal Knobs of <i>Zea mays</i> L. and Agronomic Performance<sup>1</sup> (1972)

Four polymorphic chromosome knobs in the open‐ pollinated variety of Zea mays L., ‘Jarvis,’ were found to be associated with effects related to plant vigor. Random inbred lines of the variety were categorized for knob constitution at each of the four knob sites. Inbreds of similar knob constitution were intermated to produce subpopulations with known knob constitution. The subpopulations were evaluated for four quantitative traits in replicated trials. Heteromorphic knob constitution was associated with greater ear height and plant height at four knob sites, and with higher yield of grain at three of the knob sites.
Tunable terahertz quantum cascade lasers with an external cavity (2007)

Tunable quantum cascade lasers operating in the terahertz frequency range are demonstrated. By using an external cavity based on the reflection from a movable mirror, both broad and fine tuning of the frequency are achieved by varying the cavity length. Coarse tuning up to 3cm−1 is obtained near the center frequency of 4.8THz (∼160cm−1), and continuous mode-hop-free tuning is observed over ∼ 0.4cm−1, nearly corresponding to the cavity free spectral range.