gebhart/patrepeval huggingface dataset:
Application of a Spectroscopic Infrared Focal Plane Array Sensor for On-Line Identification of Plastic Waste (1997)

A spectroscopic near-infrared imaging system, using a focal plane array (FPA) detector, is presented for remote and on-line measurements on a macroscopic scale. On-line spectroscopic imaging requires high-speed sensors and short image processing steps. Therefore, the use of a focal plane array detector in combination with fast chemometric software is investigated. As these new spectroscopic imaging systems generate so much data, multivariate statistical techniques are needed to extract the important information from the multidimensional spectroscopic images. These techniques include principal component analysis (PCA) and linear discriminant analysis (LDA) for supervised classification of spectroscopic image data. Supervised classification is a tedious task in spectroscopic imaging, but a procedure is presented to facilitate this task and to provide more insight into and control over the composition of the datasets. The identification system is constructed, implemented, and tested for a real-world application of plastic identification in municipal solid waste.
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients (2009)

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary subcortical vascular dementia. It is caused by mutations in NOTCH3 gene, which encodes a large transmembrane receptor Notch3. The key pathological finding is the accumulation of granular osmiophilic material (GOM), which contains extracellular domains of Notch3, on degenerating vascular smooth muscle cells (VSMCs). GOM has been considered specifically diagnostic for CADASIL, but the reports on the sensitivity of detecting GOM in patients' skin biopsy have been contradictory. To solve this contradiction, we performed a retrospective investigation of 131 Finnish, Swedish and French CADASIL patients, who had been adequately examined for both NOTCH3 mutation and presence of GOM. The patients were examined according to the diagnostic practice in each country. NOTCH3 mutations were assessed by restriction enzyme analysis of specific mutations or by sequence analysis. Presence of GOM was examined by electron microscopy (EM) in skin biopsies. Biopsies of 26 mutation-negative relatives from CADASIL families served as the controls. GOM was detected in all 131 mutation positive patients. Altogether our patients had 34 different pathogenic mutations which included three novel point mutations (p.Cys67Ser, p.Cys251Tyr and p.Tyr1069Cys) and a novel duplication (p.Glu434_Leu436dup). The detection of GOM by EM in skin biopsies was a highly reliable diagnostic method: in this cohort the congruence between NOTCH3 mutations and presence of GOM was 100%. However, due to the retrospective nature of this study, exact figure for sensitivity cannot be determined, but it would require a prospective study to exclude possible selection bias. The identification of a pathogenic NOTCH3 mutation is an indisputable evidence for CADASIL, but demonstration of GOM provides a cost-effective guide for estimating how far one should proceed with the extensive search for a new or an uncommon mutations among the presently known over 170 different NOTCH3 gene defects. The diagnostic skin biopsy should include the border zone between deep dermis and upper subcutis, where small arterial vessels of correct size are located. Detection of GOM requires technically adequate biopsies and distinction of true GOM from fallacious deposits. If GOM is not found in the first vessel or biopsy, other vessels or additional biopsies should be examined.
Survival of actively cooled microvascular polymer matrix composites under sustained thermomechanical loading Part A Applied science and manufacturing (2016)

Exposure to high heat can cause polymer matrix composites (PMC) to fail under mechanical loads easily sustained at room temperature. However, heat is removed and temperature reduced in PMCs by active cooling through an internal vascular network. Here we compare structural survival of PMCs under thermomechanical loading with and without active cooling. Microchannels are incorporated into autoclave-cured carbon fiber/epoxy composites using sacrificial fibers. Time-to-failure, material temperature, and heat removal rates are measured during simultaneous heating on one face (5–75kW/m²) and compressive loading (100–250MPa). The effects of applied compressive load, heat flux, channel spacing, coolant flow rate, and channel distance from the heated surface are examined. Actively cooled composites containing 0.33% channel volume fraction survive without structural failure for longer than 30min under 200MPa compressive loading and 60kW/m² heat flux. In dramatic comparison, non-cooled composites fail in less than a minute under the same loading conditions.
Potential impact of advanced clinical information technology on healthcare in 2015. (2004)

Clinical information technologies now sporadically available will soon be in routine clinical use, bringing many changes to healthcare. For example, 1) The next generation Internet; 2) Real-time clinical decision support systems; 3) Off-line, population-based systems; 4) Large, integrated, individual patient-level phenotypic and genotypic databases with intelligent data mining capabilities; 5) Wireless, invasive and non-invasive physiologic monitoring devices; 6) Natural Language Processing (NLP) systems; and 7) Mathematical models of complex biological systems have the potential to impact significantly the future healthcare delivery system. While new information management and communication techniques and technologies will reduce many of the inefficiencies and inaccuracies of our present systems, there will be an equal, and potentially far more dangerous, set of unintended consequences. Informatics investigators and health system administrators must focus on the study of what is working and what is not, as well as, on development and testing of the new clinical information management and communication technologies, if we are to be ready for the future.
McCarey-Kaufman Technique of Corneal Storage Before Penetrating Keratoplasties in Rabbits (1976)

The endothelial function of rabbit corneas stored in modified tissue culture medium (McCarey-Kaufman medium) for periods of 4, 8, or 12 days was studied after penetrating keratoplasty using the specular microscope and the response to temperature reversal. Our results indicate that rabbit donor corneas stored in McCarey-Kaufman (M-K) medium are suitable for penetrating keratoplasty after storage periods as long as 12 days. The limitations of using graft clarity or the morphologic appearance of the endothelium as an index of the success of a penetrating keratoplasty in the rabbit are discussed.
Design Methodology for Yield Enhancement of Switched-Capacitor Analog Integrated Circuits (2011)

Device mismatch plays an important role in the design of accurate analog circuits. The common centroid structure is commonly employed to reduce device mismatches caused by symmetrical layouts and processing gradients. Among the candidate placements generated by the common centroid approach, however, whichever achieves better matching is generally difficult to be determined without performing the time-consuming yield evaluation process. In addition, this rule-based methodology makes it difficult to achieve acceptable matching between multiple capacitors and to handle an irregular layout area. Based on a spatial correlation model, this study proposed a design methodology for yield enhancement of analog circuits using switched-capacitor techniques. An efficient and effective placement generator is developed to derive a placement for a circuit to achieve the highest or near highest correlation coefficient and thus accomplishing a better yield performance. A simple yield analysis is also developed to evaluate the achieved yield performance of a derived placement. Results show that the proposed methodology derives a placement which achieves better yield performance than those generated by the common centroid approach.
Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3'-oxindole] Compounds (2009)

Article Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3'-oxindole] Compounds was published on October 1, 2009 in the journal Heterocyclic Communications (volume 15, issue 5).
CHEMICAL MODIFICATION OF WOOD TO PRODUCE STABLE AND DURABLE COMPOSITES (2012)

Dimensionally stable solid wood and wood composites can be achieved by several methods, including cell wall bulking, cell wall polymer crosslinking and removal of hygroscopic components in the cell wall. Bulking the cell wall with bonded chemicals produces dimensionally stable products that can withstand wet and dry cycles. Crosslinking with a short difunctional chemical, such as formaldehyde, can produce dimensionally stable products that can also be used in wet-dry cycles and the amount of chemical add-on is very small (4 to 6%), but the wood is brittle. Wood heated to temperatures where the hygroscopic hemicellulose polymers are degraded produces a dimensionally stable product, but with reduced strength. Controlling the moisture content in the cell wall is one of the keys to biological resistance. If the equilibrium moisture content in the cell wall is below that required for a microorganism to attack wood, the chemically modified wood is then resistant to attack. The modification of the configuration and conformation of the substrate polymers, so that enzyme recognition cannot take place, may also be part of the protection mechanism.
Putting personas to work (2006)

Personas for use in interaction and interface design have generated a great deal of interest, but the method is still relatively new. This panel brings together professionals who have used personas to solve real business problems. The panelists will describe the methods they have developed to put personas to work in their organizations and how the use of personas has impacted their products and their organizations.
Jointly Fine-Tuning “BERT-Like” Self Supervised Models to Improve Multimodal Speech Emotion Recognition (2020)

Multimodal emotion recognition from speech is an important area in affective computing. Fusing multiple data modalities and learning representations with limited amounts of labeled data is a challenging task. In this paper, we explore the use of modality-specific "BERT-like" pretrained Self Supervised Learning (SSL) architectures to represent both speech and text modalities for the task of multimodal speech emotion recognition. By conducting experiments on three publicly available datasets (IEMOCAP, CMU-MOSEI, and CMU-MOSI), we show that jointly fine-tuning "BERT-like" SSL architectures achieve state-of-the-art (SOTA) results. We also evaluate two methods of fusing speech and text modalities and show that a simple fusion mechanism can outperform more complex ones when using SSL models that have similar architectural properties to BERT.
Model predictive control of nonlinear systems: Computational burden and stability (2000)

Implementation of model predictive control (MPC) for nonlinear systems requires the online solution of a nonconvex, constrained nonlinear optimisation problem. Computational delay and loss of optimality arise in the optimisation procedures. The paper presents a practical MPC scheme for nonlinear systems with guaranteed asymptotic stability. It is shown that when an initial control profile is chosen to satisfy an inequality condition in each online optimisation procedure, the nonlinear system under the proposed nonlinear MPC is asymptotically stable. The stability condition presented in the paper enables the `fictitious' terminal control to be nonlinear, rather than only linear, thus the stability region is greatly enlarged. Furthermore it is pointed out that nominal stability is still guaranteed even though the global, or even the local, minimisation of the objective cost is not achieved within the prescribed computational time.
Determination of DNA Damage in F344 Rats Induced by Geometric Isomers of Tamoxifen and Analogues (1998)

To investigate the activation mechanisms involved in tamoxifen carcinogenicity, analogues of tamoxifen isomers modified at the ethyl group were synthesized and assessed for their ability to induce hepatic DNA damage following their administration to female F344 rats. The cis isomer was prepared by acid-catalyzed isomerization of tamoxifen and isolated by preparative HPLC. The active metabolite alpha-hydroxytamoxifen and geometric isomers of bromotamoxifen and C-desmethylenetamoxifen, analogues in which the ethyl group has been replaced by a bromine atom and methyl group, respectively, were synthesized according to published procedures. The levels of hepatic DNA adducts induced were determined by 32P-postlabeling. Bromotamoxifen and tamoxifen 1,2-epoxide caused no detectable DNA damage relative to controls. Trans isomers of tamoxifen, C-desmethylenetamoxifen, and alpha-hydroxytamoxifen all produced DNA adducts at a 5-90-fold higher level than the corresponding cis isomers. In contrast, both the cis and trans isomers of alpha-hydroxytamoxifen showed similar reactivity toward calf thymus DNA in vitro. Molecular models of alpha-hydroxytamoxifen isomers suggest this difference in DNA adduct-forming ability is due to steric hindrance of the enzymes involved in the activation of this metabolite. There were high adduct levels in the liver, but no uterine DNA adducts were detected in rats treated with alpha-hydroxytamoxifen. This suggests that in contrast to the liver, alpha-hydroxytamoxifen is not further activated in rat uterus. This may help to explain the absence of uterine tumors in rats following long-term tamoxifen treatment.
Full-chip vectorless dynamic power integrity analysis and verification against 100uV/100ps-resolution measurement (2004)

The advances in semiconductor manufacturing, EDA tools, and VLSI design technologies are enabling circuit designs with increasingly higher speed and density. However, this trend is causing the on-chip power distribution network to experience larger dynamic voltage fluctuations due to dynamic voltage drop, L di/dt noise, and/or LC resonance. As a result, the analysis of power-integrity, as well as the evaluation and calibration of the analysis methodology, has become a major challenge in designing high-performance circuits. An innovative vectorless dynamic power-ground noise analysis approach is discussed in this paper. This approach addresses full-chip complexity with transistor-level accuracy. This analysis approach demonstrated very good correlation with an on-chip supply noise measurement in 0.13-/spl mu/m CMOS technology, capable of achieving 100 /spl mu/V/100 ps resolution.
Molting and Salmonella enterica serovar enteritidis infection: the problem and some solutions (2003)

Induced molting is an important economic tool used by the egg industry to recycle an aging layer flock. It is estimated that approximately 70% of the flocks nationwide and almost 100% in California are molted annually. Considering that there are approximately 240 million hens in production in the U.S., a rough estimate of the numbers of hens molted every year would be between 144 and 168 million birds, a substantial number. There are many methods to induce molt, but feed removal until hens lose a specific weight is the most prevalent molt strategy in the U.S. However, experimental studies in our laboratory have shown that induced molting via feed removal depresses the immune system of hens and exacerbates a Salmonella enteritidis (SE) problem in a simulated flock situation. Molted hens excreted significantly higher SE numbers in the feces, had higher numbers of SE in internal organs, and exhibited more intestinal inflammation. Molted hens were 100- to 1,000-fold more susceptible to infection by SE and therefore more readily transmitted the organism to uninfected hens in neighboring cages. With the problems identified, solutions were sought, and several were successful in ameliorating the SE issue. Antibiotic therapy, vaccination, and use of low-energy, low-calcium diets to molt hens all dramatically decreased SE shedding during molt. All of the solutions provide the producer with many potential solutions to the SE food safety issue and still allow them to recycle their hens.
Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells (2015)

Cytomegalovirus (CMV) is a herpesvirus that persists for life and maintains extremely large numbers of T cells with select specificities in circulation. However, it is unknown how viral persistence impacts T cell populations in mucosal sites. We found that many murine (M)CMV-specific CD8s in mucosal tissues became resident memory T cells (TRM). These cells adopted an intraepithelial localization in the salivary gland that correlated with, but did not depend on, expression of the integrin CD103. MCMV-specific TRM cells formed early after infection, and spleen-localized cells had reduced capacities to become TRM at late times. Surprisingly, however, small numbers of new TRM cells were formed from the circulating pool throughout infection, favoring populations maintained at high levels in the blood and shifting the immunodominance within the TRM populations over time. These data show that mucosal TRM populations can be dynamically maintained by a persistent infection.
Using color and texture indexing to improve collaborative filtering of art paintings (1999)

Information filtering is a key technology for the creation of Web sites, which are adapted to the user&apos;s needs. In this paper we identify collaborative filtering and content-based filtering as independent technologies for information filtering. We apply both technologies in our prototype user-adapting Web site, the ActiveWebMuseum, a recommender system for art paintings. Our new approach extends existing user profiles with content-based information gained through automatic image indexing. These extensions lead to a better performing collaborative filtering system. We validate our approach in off-line experiments.
Automatic Generation of Normalized Relational Schemas from Nested Key-Value Data (2016)

Self-describing key-value data formats such as JSON are becoming increasingly popular as application developers choose to avoid the rigidity imposed by the relational model. Database systems designed for these self-describing formats, such as MongoDB, encourage users to use denormalized, heavily nested data models so that relationships across records and other schema information need not be predefined or standardized. Such data models contribute to long-term development complexity, as their lack of explicit entity and relationship tracking burdens new developers unfamiliar with the dataset. Furthermore, the large amount of data repetition present in such data layouts can introduce update anomalies and poor scan performance, which reduce both the quality and performance of analytics over the data.
Auto Iris Pigment Epithelial Cell Transplantation in Patients with Age-Related Macular Degeneration: Short-Term Results (2000)

Autologous iris pigment epithelial cell transplantation was performed on patients with exudative age-related macular degeneration (AMD). Autologous IPE cell culture was performed using autologous serum after iridectomy in 7 patients with AMD. The cell suspensions (2 approximately 20 x 10(4) cells) were transplanted into the submacular lesion of individuals after removal of neovascular membranes. Subsequent ophthalmological examinations, including best corrected visual acuity and fluorescein or indocyanine green angiography, were performed. In addition, 15 patients with AMD, who underwent removal of neovascular membrane without transplantation, were evaluated as non randomized controls. Varying degrees of atrophy or defects of choriocapillaris and retinal pigment epithelium were observed in all of the patients. No cystoid macular edema or fluorescein leakage was observed after treatment, but window defects were present. No patient had decreased visual acuity. One treated patient developed mild subretinal fibrosis and an other patient developed mild preretinal fibrosis, however no difference was significant when compared with the control. In conclusion, the treatment resulted in no significant improvement in macular function, as compared with the control; however, no rejection or deterioration in visual acuity occurred up to the 13 month follow up.
Automated Security Configuration Checklist for Apple iOS Devices Using SCAP v1.2 (2018)

The security content automation includes configurations of large number of systems, installation of patches securely, verification of security-related configuration settings, compliance with security policies and regulatory requirements, and ability to respond quickly when new threats are discovered [1]. Although humans are important in information security management, humans sometimes introduce errors and inconsistencies in an organization due to manual nature of their tasks [2]. Security Content Automation Protocol was developed by the U.S. NIST to automate information security management tasks such as vulnerability and patch management, and to achieve continuous monitoring of security configurations in an organization. In this paper, SCAP is employed to develop an automated security configuration checklist for use in verifying Apple iOS device configuration against the defined security baseline to enforce policy compliance in an enterprise.
Radio Frequency Identification Technology and Application Research (2010)

Radio Frequency Identification(RFID) is a non-contact automatic identification technology,which exchanges data and distinguishes object between the reader and the electronic tag using radio frequency signals via wireless transmission means.Compared with the traditional bar code identification technology,RFID has many advantages,such as longrange identification,environmental adaptability,a large amount of data storage,identifying multiple objects,and so on,therefore,has been widely used in industry,retail,logistics,transportation,and other fields.This paper analyses tech-nology features and working principle of the radio frequency identification,describes the composition of the system and the implementation process,pointes out the facing problems,and looks out the future development trends.
Cyclic lactam analogs of Ac-[Nle4].alpha.-MSH4-11-NH2 (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic lactam analogs of Ac-[Nle4].alpha.-MSH4-11-NH2Elizabeth E. Sugg, Ana Maria De L. Castrucci, Mac E. Hadley, Georges Van Binst, and Victor J. HrubyCite this: Biochemistry 1988, 27, 21, 8181–8188Publication Date (Print):October 18, 1988Publication History Published online1 May 2002Published inissue 18 October 1988https://pubs.acs.org/doi/10.1021/bi00421a029https://doi.org/10.1021/bi00421a029research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts