gebhart/patrepeval huggingface dataset:
Probing for Cerebrospinal Fluid Antibody Specificities by a Panel of Random Peptide Libraries (1997)

In a state of health the central nervous system is nearly devoid of macrophages, T and B cells. However, such cells are required to initiate the inflammation associated with multiple sclerosis (MS). An important issue in understanding the pathogenesis of such conditions is to fully define the T and B cell specificities. Using random peptide libraries, we have analysed the cerebrospinal fluid antibody specificities within one oligoclonal "band" from a patient with MS. The selected peptides from a 6-mer library revealed two peptide motifs S (S/T/Q) (R/S) (N/G) FP and PRn (G/P) FF. Interestingly, the first motif was also selected from a 15-mer library, while the second motif was selected from the 9-mer library. In addition, distinct but structurally related peptides to the mentioned motifs were also selected. Surprisingly, a SwissProt search with these motifs revealed a significant linear homology with collagen proteins, the 68 kDa neurofilament protein, versican and other proteins from viruses such as herpes simplex virus, human cytomegalovirus and human papillomavirus. Thus, the observation that antibodies present within one oligoclonal immunoglobulin band would recognize peptides, some that might be related by only the structure, raises the question of the involvement of multiple pathogens in MS.
Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study [see comments] (1994)

Incubation of chronic myeloid leukemia (CML) marrow for 10 days in vitro causes a marked and selective loss of very primitive Philadelphia chromosome (Ph)+ as compared with Ph- progenitors. We have autografted 22 patients with CML (16 in first chronic phase [group 1] and 6 with more advanced disease [group 2]) with marrow treated in this way to facilitate restoration of Ph- hematopoiesis after intensive therapy. Hematologic recovery to greater than 0.5 x 10(9)/L neutrophils occurred in 16 patients, and to greater than 20 x 10(9)/L platelets in 15 of 21 evaluable patients at a median of 29 and 48 days postautograft, respectively. Regenerating marrow cells were 100% Ph- in 13 patients and 75% to 94% Ph- in 3. Between 4 and 36 months (median 12) postautograft, Ph+ cells became detectable in all but 1 (who died in remission) of the 13 patients who achieved complete cytogenetic remission. Four of 7 evaluable patients treated with low-dose interferon alpha were returned to complete cytogenetic remission. Thirteen group 1 patients (81%) are alive 1.0 to 5.7 years (median 2.6) after autografting: 4 in complete cytogenetic remission, 2 in hematologic remission, 6 in chronic phase, and 1 in myeloid blast phase. Three group 2 patients (50%) are alive at 2.6, 3.8, and 4.3 years after autografting: 1 in partial cytogenetic remission, 1 in chronic phase, and 1 in accelerated phase. Thus, autografts of cultured marrow can result in prolonged restoration of Ph- hematopoiesis for some patients with CML.
Large field-of-view Fourier transform imaging spectrometer using dual-channel stitching (2016)

A dual-channel lateral shearing beam splitter was used in a Fourier transform imaging spectrometer, forming a dual-channel imaging spectrometer, to investigate the usability of this technique for large field-of-view (FOV) spectral detection. The large FOV obtained by stitching together the different channels' individual FOVs greatly improved the spectral detection efficiency for large-area targets. This report describes the principle of the dual-rectangle lateral shearing beam splitter and the analysis of the lateral shearing distance, FOV, modulation, and method of dual-channel stitching. Large-FOV spectral images of a scene were acquired experimentally at visible wavelengths, confirming the effectiveness of this technique.
Impact of Bottom Electrode Integration on OxRAM Arrays Variability (2020)

HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -based OxRAMs with various metal stacks in the inferior VIA of bottom electrode were fabricated. We demonstrated for the first time that the metal stack of TiN PVD (physical vapour deposition), followed by an annealing step decreases the standard error of the forming voltage by 10% compared to the other variants. The related die-to-die and cell-to-cell variability is greatly reduced along the wafer diameter and the LRS shows better control of the tail bits at 3 of the distribution. The number of failed operations over 1e4 cycles for 1k cells is reduced by a factor 3, reaching a BER of 8e-5. Finally, correlation of the cell reliability with the bottom via roughness is discussed.
Autonomous lane-change controller via mixed logical dynamical (2014)

This paper focuses on the design of a model based methodology to optimize lane change maneuvers based on the predictions of neighboring agents. In particular, the dynamics of vehicles are modeled as double integrators, and the lane change actions are indicated by boolean variables while neglecting the lane change dynamics. The objective of the optimal control is to minimize the travel time, maintain saftey distances between the target vehicle and neighboring ones, satisfy the operational constraints of the target vehicle, and comply with the speed limit. The control problem is formulated as a mixed logic dynamic system, and solved by Cplex, a commercial mixed integer optimization solver. Finally, the effectiveness of the proposed methodology is demonstrated by two simulated scenarios in this paper.
Facet and in-plane crystallographic orientations of GaN nanowires grown on Si(111) (2008)

We have determined the in-plane orientation of GaN nanowires relative to the Si (111) substrate on which they were grown. We used x-ray diffraction pole figure measurements to evidence two types of crystallographic orientation, all the nanowires having [Formula: see text] lateral facets. The proportion of these two orientations was determined and shown to be influenced by the pre-deposition of Al(Ga)N intermediate layers. In the main orientation, the GaN basal [Formula: see text] directions are aligned with the [Formula: see text] directions. This orientation corresponds to an in-plane coincidence of GaN and Si lattices.
V-V Compounds (2008)

This article describes V-V compounds constructions that have inspired the lexicon-versus-syntax debate for the place of morphology. It explores the issues that constitute the basis for considering several analyses of V-V compounds—aspectual and psychological compounds and headedness—and some major lexical and syntactic analyses. The article then considers how they fare empirically with the main properties of V-V compounds. Some complex cases are provided as illustrations of the recalcitrant aspects of V-V compounds. It finally explains the theoretical implications from the discussion on V-V compounds. It is hoped that the article will provide a basis for further research on V-V compounds, which directly touch on the important issue of the place of morphology in linguistic theory.
Induction and prevention of type 1 diabetes mellitus by viruses. (1993)

Genetic factors and environmental factors are thought to be involved in the pathogenesis of insulin-dependent diabetes mellitus Type 1. Viruses, as one environmental factor, may act as primary injurious agents to beta cells or as triggering agents for autoimmunity. Some viruses such as EMC-D and Coxsackie B4 can induce Type 1 diabetes by infecting and destroying beta cells in genetically susceptible mice. In addition, certain species of monkey, such as Patas, show elevated blood glucose levels and depressed insulin secretion after infection with Coxsackie B4 virus. An occasional case of Type 1 diabetes mellitus appears to be associated with the infection of beta cells with Coxsackie B viruses. In addition, Coxsackie B4 virus may also generate viral antigen-specific cytotoxic T cells which may cross-react with a beta cell-specific autoantigen leading to autoimmune Type 1 diabetes. In the case of viral triggering of autoimmune Type 1 diabetes, certain viruses (eg, retrovirus in NOD mice and rubella virus in hamsters and humans) may alter a normally existing beta cell antigen into an immunogenic form or might induce a new antigen, leading to beta cell-specific autoimmune insulin dependent diabetes mellitus. In addition, other viruses (eg, Kilham's rat virus in DR-BB rats) could generate antigen-specific T effector cells which may cross-react with a beta cell-specific autoantigen. In contrast to the induction of diabetes, viruses can prevent the development of diabetes. Inoculation of DP-BB or NOD mice with lymphocytic choriomeningitis virus reduced the incidence of diabetes or prevented the disease by disordering particular lymphocyte subsets.(ABSTRACT TRUNCATED AT 250 WORDS)
Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases (2015)

Tumor organoids are 3D cultures of cancer cells. They can be derived from the tumor of each individual patient, thereby providing an attractive ex vivo assay to tailor treatment. Using patient-derived tumor organoids for this purpose requires that organoids derived from biopsies maintain the genetic diversity of the in vivo tumor. In this study tumor biopsies were obtained from 14 patients with metastatic colorectal cancer (i) to test the feasibility of organoid culture from metastatic biopsy specimens and (ii) to compare the genetic diversity of patient-derived tumor organoids and the original tumor biopsy. Genetic analysis was performed using SOLiD sequencing for 1,977 cancer-relevant genes. Copy number profiles were generated from sequencing data using CopywriteR. Here we demonstrate that organoid cultures can be established from tumor biopsies of patients with metastatic colorectal cancer with a success rate of 71%. Genetic analysis showed that organoids reflect the metastasis from which they were derived. Ninety percent of somatic mutations were shared between organoids and biopsies from the same patient, and the DNA copy number profiles of organoids and the corresponding original tumor show a correlation of 0.89. Most importantly, none of the mutations that were found exclusively in either the tumor or organoid culture are in driver genes or genes amenable for drug targeting. These findings support further exploration of patient-derived organoids as an ex vivo platform to personalize anticancer treatment.
Development of new measurement system of thoracic excursion with biofeedback: reliability and validity (2013)

The novel measurement system, BREATH, has high intra- and inter-evaluator reliabilities and validity; therefore it can lead us more effective respiratory exercise. Using its biofeedback data, this system may help patients with respiratory disease to do exercises more efficiently and clinicians to assess the respiratory exercise more accurately.
Sensitive method for the rapid determination of phytate in cereals and cereal products (1983)

Abstract A rapid method is described for the colorimetric determination of 1.5–15 μg phytate phosphorus in concentrations as low as 3 μg ml −1 in extracts of cereal grains and cereal products. The phytic acid is precipitated with an acidic iron‐III‐solution of known iron content. The decrease of iron in the supernatant is a measure for the phyticacid content.
Microphthalmia transcription factor: a specific marker for malignant melanoma. (2004)

The transcription factor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstream transcriptional targets of MITF. It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors.
Electrochemical Behavior of Oxide Films of Stainless Steel in 40 kHz Sonicated Sulphate Electrolytes (2007)

这篇论文在硫酸盐电解质在不锈钢的氧化物电影上描述 40 kHz 超声的效果以便决定播送力量并且在电极表面上描绘质传和山峰电流密度。强调主要在声音的 ated 硫酸盐答案(0.5 和 1.0 mol/L ) 在电气化学的氧化和氧化物电影的脱皮的机制上被生。极化 voltammetry，当前的反应踪迹和 SEM 分析被执行以便至于氧化物电影表面提供完整的信息。电气化学的氧化，极化曲线的形状和在声音的 ated 硫酸盐电解质的表面显微图的率与没有超声的介绍，获得的那些不同的结果表演。超声罐头由它的 cavitaion 效果改变氧化物电影的电气化学的行为，这被结束，它将生产短暂机械冲动的力量并且提高电气化学的反应。
The mechanisms and dynamics of αvβ3 integrin clustering in living cells (2005)

During cell migration, the physical link between the extracellular substrate and the actin cytoskeleton mediated by receptors of the integrin family is constantly modified. We analyzed the mechanisms that regulate the clustering and incorporation of activated alphavbeta3 integrins into focal adhesions. Manganese (Mn2+) or mutational activation of integrins induced the formation of de novo F-actin-independent integrin clusters. These clusters recruited talin, but not other focal adhesion adapters, and overexpression of the integrin-binding head domain of talin increased clustering. Integrin clustering required immobilized ligand and was prevented by the sequestration of phosphoinositole-4,5-bisphosphate (PI(4,5)P2). Fluorescence recovery after photobleaching analysis of Mn(2+)-induced integrin clusters revealed increased integrin turnover compared with mature focal contacts, whereas stabilization of the open conformation of the integrin ectodomain by mutagenesis reduced integrin turnover in focal contacts. Thus, integrin clustering requires the formation of the ternary complex consisting of activated integrins, immobilized ligands, talin, and PI(4,5)P2. The dynamic remodeling of this ternary complex controls cell motility.
Plasmacytoid Dendritic Cells Are Crucial in Bifidobacterium adolescentis-Mediated Inhibition of Yersinia enterocolitica Infection (2013)

In industrialized countries bacterial intestinal infections are commonly caused by enteropathogenic Enterobacteriaceae. The interaction of the microbiota with the host immune system determines the adequacy of an appropriate response against pathogens. In this study we addressed whether the probiotic Bifidobacterium adolescentis is protective during intestinal Yersinia enterocolitica infection. Female C57BL/6 mice were fed with B. adolescentis, infected with Yersinia enterocolitica, or B. adolescentis fed and subsequently infected with Yersinia enterocolitica. B. adolescentis fed and Yersinia infected mice were protected from Yersinia infection as indicated by a significantly reduced weight loss and splenic Yersinia load when compared to Yersinia infected mice. Moreover, protection from infection was associated with increased intestinal plasmacytoid dendritic cell and regulatory T-cell frequencies. Plasmacytoid dendritic cell function was investigated using depletion experiments by injecting B. adolescentis fed, Yersinia infected C57BL/6 mice with anti-mouse PDCA-1 antibody, to deplete plasmacytoid dendritic cells, or respective isotype control. The B. adolescentis-mediated protection from Yersinia dissemination to the spleen was abrogated after plasmacytoid dendritic cell depletion indicating a crucial function for pDC in control of intestinal Yersinia infection. We suggest that feeding of B. adolescentis modulates the intestinal immune system in terms of increased plasmacytoid dendritic cell and regulatory T-cell frequencies, which might account for the B. adolescentis-mediated protection from Yersinia enterocolitica infection.
Mapping functional regions in the lumenal domain of the class II-associated invariant chain. (1994)

The MHC class II-associated invariant chain interacts in trimeric form with class II molecules, inhibits peptide binding, and mediates targeting of class II molecules to endosomal compartments. To dissect the different functions of the invariant (Ii) chain, a set of cDNAs, encoding truncated forms of the Ii chain, was constructed. mRNAs, transcribed from these cDNAs were translated in vitro, together with mRNAs encoding class II HLA DR1 alpha and beta subunits. An Ii chain truncation that contains the 104 NH2-terminal amino acids was able to associate with class II molecules. This construct contains the region from which class II-associated Ii chain peptides (CLIP, amino acids 81-104) are derived. The absence of a further eight residues at the COOH terminus results in a construct of 96 amino acids that is unable to associate with class II molecules. Association of the truncated Ii chains with class II molecules showed a strict correlation with inhibition of peptide binding. Removal of the NH2-terminal cytoplasmic tail and transmembrane region of Ii chain and its replacement with a cleavable signal sequence led to aberrant folding and impaired association with class II molecules. The region between amino acids 163 and 183 was found to be essential for visualization of Ii chain homotrimers by covalent cross-linking.
The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia (2008)

Together these results demonstrate that CXCL12/CXCR4 expression begins in the pre-invasive stages of pancreatic neoplasia, and suggest that the presence of an autocrine loop that is at least partially regulated by MAPK signalling. Further studies that define the role of CXCR4 signalling in PanIN progression will determine if CXCR4 could serve as a novel target for chemoprevention and early stage therapy in pancreatic cancer.
Intraoperative Death Associated with Acrylic Bone Cement (1972)

Two cases of sudden death occurred during the insertion of hip prostheses with the use of methyl methacrylate polymer as bone cement. In one case in which an autopsy was performed, widespread marrow emboli were found. Hypotension was also an additional factor in cardiopulmonary collapse.
Arbitration and shuffling algorithm for processing multiple commands in SDRAM controller (2014)

In this paper, we propose an algorithm of arbitration and shuffling of requests for a memory controller which enables high bandwidth, low latency and low power consumption in systems with SoC network protocols that support outstanding address and out-of-order completion transactions. The memory access commands are stored in a queue, analyzed and shuffled in order to minimize activating new rows and to reduce the power consumption in the proposed architecture. It also adjusts the priority of processing commands if the network protocol supports QoS. We compare the performance of the proposed algorithm for the various memory access patterns.
Four-Choice Win-Stay Water Escape Acquisition by Rats (1990)

Rats were capable of acquiring a four-choice win-stay water-escape task. While preventing access to the incorrect choice sections on information runs affected the first choices made on test runs, it did not affect rate of acquisition.
Aluminum and Nickel Matrix Composites Reinforced by CNTs: Dispersion/Mixture by Ultrasonication (2017)

The main challenge in the production of metal matrix composites reinforced by carbon nanotubes (CNTs) is the development of a manufacturing process ensuring the dispersion of nanoparticles without damaging them, and the formation of a strong bond with the metallic matrix to achieve an effective load transfer, so that the maximum reinforcement effect of CNTs will be accomplished. This research focuses on the production by powder metallurgy of aluminum and nickel matrix composites reinforced by CNTs, using ultrasonication as the dispersion and mixture process. Microstructural characterization of nanocomposites was performed by optical microscopy (OM), scanning and transmission electron microscopy (SEM and TEM), electron backscattered diffraction (EBSD) and high-resolution transmission electron microscopy (HRTEM). Microstructural characterization revealed that the use of ultrasonication as the dispersion and mixture process in the production of Al/CNT and Ni/CNT nanocomposites promoted the dispersion and embedding of individual CNT in the metallic matrices. CNT clusters at grain boundary junctions were also observed. The strengthening effect of the CNTs is shown by the increase in hardness for all nanocomposites. The highest hardness values were observed for Al/CNT and Ni/CNT nanocomposites, with a 1.00 vol % CNTs.
[Pathologic cataract due to ovarian failure]. (1990)

The analysis of a group of 289 presenile cataracts, in patients between 31 and 60 years old showed that 33 cases were due to ovarian insufficiency, 9 of them appeared after ovariectomies for ovarian cyst, 9 after hysterectomies, 4 after other obstetrical and gynecological surgeries, 2 after ovarian inflammatory processes and 9 were generated by central ovarian insufficiency with precocious menopause. The low secretion of ovarian hormones and mainly of estrogenic hormones induces--at the level of sensitive receptors--involutive modifications such as the lens opacification.
Optimal periodic training signal for frequency offset estimation in frequency selective fading channels (2004)

This paper addresses optimal periodic training signal design for frequency offset estimation in frequency selective multipath Rayleigh fading channels. For a fixed transmitted training signal energy and within a fixed length block, the optimal periodic training signal structure (the optimal location of identical training subblocks) and the optimal training subblock signal are presented. The optimality is based on the minimum Cramer-Rao bound (CRB) criterion. Based on the snap-shot CRB, the optimal periodic training structure is derived. The optimal training subblock signal is obtained by utilizing the average CRB and the received training signal statistics. The optimal training structure with optimal training signals achieves substantial performance improvement over nonoptimal training structure with nonoptimal training signals.
Histochemistry of Lignin Deposition during Sclerenchyma Differentiation in Alfalfa Stems (1996)

The spatial deposition of lignin within the cell walls layer of sclerenchyma is distinct from the lignification pattern of secondary xylem cell walls. Histochemical staining and autofluorescence of the cell walls during alfalfa internode ageing clearly showed that lignin deposition first occurs in the secondary cell walls of the differentiating sclerenchyma. This is in contrast to the widely reported lignification pattern in secondary xylem where lignins are incorporated in the primary cell walls prior to the secondary walls. Spatial variations in the onset of lignin deposition are accompanied by differences in the frequency of the di-methoxylated lignin monolignol (i.e. syringyl unit) depending on the nature of the tissue. Modifications of the lignin composition are also related to the physiological stage of alfalfa internodes.
Average Voltage, Energy Density, and Specific Energy of Lithium‐Ion Batteries: Calculation Based on First Principles (1997)

The theoretical average voltage, energy density (energy per volume), and specific energy (energy per mass) based on the active electrode material have been calculated from first principles for two types of rechargeable lithium-ion batteries. In the charged state the two batteries consist of LiC<sub>6</sub> and MO<sub>2</sub> electrodes (M = Mo and Ni). The calculation was performed using the linearized augmented plane wave crystal code WIEN95 based on density functional theory (DFT). The structure was calculated by varying the unit cell volume of the experimentally known crystallographic data with respect to the total energy. The calculated results are compared with measured values. The temperature dependence of the average voltage, energy density, and specific energy was demonstrated to be of minor importance. In the case of the LiC<sub>6</sub>/NiO<sub>2</sub> battery this was done by calculating the vibrational energy contribution to the enthalpy change using the cluster approximation and the Amsterdam density functional (ADF) molecular code based on DFT. The agreement between theoretical and experimental values opens up the use of first principles quantum chemistry in battery technology.