gebhart/patrepeval huggingface dataset:
Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-ϵ (2004)

The ability of fibroblasts to contract three-dimensional collagen gels has been used as an in vitro model of the tissue contraction which characterises both normal repair and fibrosis. Among its actions, thrombin can activate the protease-activated receptor (PAR)1 and, thereby, stimulate inflammation and repair. The current study evaluated whether thrombin could stimulate fibroblast-mediated collagen gel contraction by activating PAR1 and whether its downstream signalling depends on protein kinase C (PKC)-epsilon. Human foetal lung fibroblasts (HFL-1) were cultured in three-dimensional collagen gels and the area of the gels was measured by image analyser. Both thrombin and TFLLR, a selective PAR1 agonist, stimulated collagen gel contraction mediated by HFL-1. After RNA interference-mediated PAR1 knockdown in HFL-1, both thrombin and the PAR1 agonist-induced gel contraction were partially inhibited (by 22.4+/-2.2% and 17.6+/-5.6%, respectively). The gel contraction stimulated by thrombin was also reduced by a nonspecific PKC inhibitor and a calcium-independent PKC-epsilon inhibitor. Both thrombin and TFLLR significantly increased PKC-epsilon activity, and this effect was blocked by PAR1 knockdown. Thrombin stimulates collagen gel contraction at least partially through activation of protease-activated receptor 1 and protein kinase C-epsilon, and may contribute to tissue remodelling in inflammatory airway and lung diseases.
A Comparison of Real-Time Polymerase Chain Reaction Assays for the Detection of Antimicrobial Resistance Markers and Sequence Typing From Clinical Nucleic Acid Amplification Test Samples and Matched Neisseria gonorrhoeae Culture (2017)

Real-time polymerase chain reaction (PCR) assays to detect antimicrobial resistance-associated mutations were tested on Neisseria gonorrhoeae-positive clinical samples with matched isolates. Of the nucleic acid amplification tests/cultures, 87.7% (64/73), 98.6% (72/73), and 98.4% (62/63) predicted cephalosporin, ciprofloxacin, and azithromycin susceptibilities, respectively. N. gonorrhoeae multiantigen sequence type was correctly predicted for 98.7% (79/80), and 13 of 58 N. gonorrhoeae-negative specimens showed false-positive results.
Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody. (1987)

Both cloned murine helper T lymphocytes (HTL) and cytolytic T lymphocytes (CTL) proliferated and secreted lymphokines when stimulated with immobilized anti-T cell receptor monoclonal antibody (anti-TCR mAb). However, although proliferation of CTL increased and reached plateau levels as concentrations of anti-TCR mAb were increased, the proliferation of HTL decreased with high concentrations of anti-TCR mAb. A reduction of IL 2-dependent proliferation by CTL was observed when IL 2 was added to cultures of CTL in the presence of high concentrations of anti-TCR mAb, whereas IL 2-independent proliferation appeared to be unaffected by these concentrations of anti-TCR mAb. Inhibition of IL 2-driven proliferation caused by high concentrations of immobilized anti-TCR mAb did not seem to be mediated by soluble factors. Cells continued to express cell surface receptors for IL 2 and transferrin after treatment with immobilized anti-TCR mAb. Inhibition of IL 2-driven proliferation by high concentrations of immobilized anti-TCR mAb may represent a mechanism for regulating the proliferation of T lymphocytes. This inhibitory mechanism is initiated by stimulation of the T cell receptor, in this case by immobilized anti-TCR mAb, and is independent of other cells and factors.
Synthese von Sieben‐ und Achtring‐anellierten Pyridinen durch “inverse” intramolekulare Diels‐Alder‐Reaktion mit Trifluormethyl‐substituierten 1,2,4‐Triazinen (1990)

Synthesis of Seven‐ and Eight‐Membered Ring‐Annulated Pyridines by “Inverse” Intramolecular Diels‐Alder Reaction with Trifluoromethyl‐Substituted 1,2,4‐Triazines Intramolecular [4 + 2] cycloaddition reactions with inverse electron demand of trifluoromethyl‐substituted 1,2,4‐triazines carrying 7‐ or 8‐membered o‐alkyne side‐chain dienophiles ( 3,8,12 ) lead to the synthesis of bicyclic pyridines with annulated heterocyclic seven‐ ( 5, 9, 13‐15 ) or eight‐membered rings ( 19, 22, 23, 26 ).
Lightweight SIMT core designs for intelligent 3D stacked DRAM (2017)

In this work we present an analysis of the Harmonica stream multiprocessor, a light-weight, parameterized, open-source single-instruction-multiple-thread (SIMT) core designed for integration within 3D-stacked DRAM. We evaluate the range of Harmonica designs afforded by the architecture's parameter space in the role of a vault-level accelerator, augmenting a design similar to the Micron Hybrid Memory Cube into an array of compact accelerated DRAM channels. In this role, with a small SRAM cache, Harmonica cores are capable of providing the requisite small footprint, energy efficiency, latency tolerance, and bandwidth demand to perform well. The instruction set and microarchitecture of Harmonica are both novel, providing a lightweight interface for thread creation within the SIMT model and a simple design that issues a single warp per cycle, simplifying the register file design compared to high-performance GPUs, and providing parameters for attributes from the number of warps and threads per warp to the number of general purpose registers per thread. For our suite of analytics-oriented benchmarks, Harmonica cores consuming on the order of 100mW of power maintain a demand for an average of 12GB/s of bandwidth while tolerating the latency present in a DRAM-based memory system.
The moderating influence of user characteristics on the relationship between user involvement and perceived usefulness of information systems (1992)

This study examines the moderating effect of user characteristics on the relationship between user involvement and perceived usefulness of ISs. Thirty-two organi2:ations with 127 users have participated in this study. Results indicate that among user characteristics, feelings about the existence of procedures to handle conflicts between users and the IS staff, years with the company, and years of IS experience produce moderating effects in the planning and design stage, or in the implementation stage of IS development.
Applying source level auto-vectorization to Aparapi Java (2014)

Parallelism dominates modern hardware design, from multi-core CPUs to SIMD and GPGPU. This bring with it, however, a need to program this hardware in a programmer-friendly manner. Traditionally, managed languages like Java have struggled to take advantage of data-parallel hardware, but projects like Aparapi provide a programming model that lets the programmer easily express the parallelism within their code, while still programming in a high-level language.
Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease (2005)

Human amyloid precursor protein (hAPP) transgenic mice with high levels of amyloid-beta (Abeta) develop behavioral deficits that correlate with the depletion of synaptic activity-related proteins in the dentate gyrus. The tyrosine kinase Fyn is altered in Alzheimer's disease brains and modulates premature mortality and synaptotoxicity in hAPP mice. To determine whether Fyn also modulates Abeta-induced behavioral deficits and depletions of synaptic activity-dependent proteins, we overexpressed Fyn in neurons of hAPP mice with moderate levels of Abeta production. Compared with nontransgenic controls and singly transgenic mice expressing hAPP or FYN alone, doubly transgenic FYN/hAPP mice had striking depletions of calbindin, Fos, and phosphorylated ERK (extracellular signal-regulated kinase), impaired neuronal induction of Arc, and impaired spatial memory retention. These deficits were qualitatively and quantitatively similar to those otherwise seen only in hAPP mice with higher Abeta levels. Surprisingly, levels of active Fyn were lower in high expresser hAPP mice than in NTG controls and lower in FYN/hAPP mice than in FYN mice. Suppression of Fyn activity may result from dephosphorylation by striatal-enriched phosphatase, which was upregulated in FYN/hAPP mice and in hAPP mice with high levels of Abeta. Thus, increased Fyn expression is sufficient to trigger prominent neuronal deficits in the context of even relatively moderate Abeta levels, and inhibition of Fyn activity may help counteract Abeta-induced impairments.
Double-Bonded Functional Groups: Vol. 2 Part 1 (1989) (1989)

The most complete resource in functional group chemistryPatai's Chemistry of Functional Groups is one of chemistry's landmark book series in organic chemistry. An indispensible resource for the organic chemist, this is the most comprehensive reference available in functional group chemistry. Founded in 1964 by the late Professor Saul Patai, the aim of Patai's Chemistry of Functional Groups is to cover all the aspects of the chemistry of an important functional group in each volume, with the emphasis not only on the functional group but on the whole molecule.
Under fire: violence in the aftermath of Black Saturday (2012)

Family violence against women increased after the Black Saturday bushfires, revealing a much neglected area of disaster recovery. A new report 'The way he tells it...' Relationships after Black Saturday (2011) by Debra Parkinson and Claire Zara, of Women's Health Goulburn North East documents research conducted over two years from late 2009 to 2011 in the fire-affected shires of Mitchell and Murrindindi in Victoria's north-east.
Variations in Host Responses and the Pathogenesis of Human Onchocerciasis (1985)

Different immune responses to Onchocerca volvulus cause considerable variation in clinical manifestations of human onchocerciasis. Onchocercal lesions result from inflammatory reactions involving immunologic mechanisms; the role of the immune system in pathogenesis is emphasized by the phenomena accompanying accelerated worm destruction during microfilaricidal chemotherapy (e.g., eosinophilia, changes in total immunoglobulin level, and anaphylactic symptoms). Although most pathologic changes are associated with the microfilarial stage, the extent to which circulating antibodies are directed against antigens in the adult worm or its uterine constituents is unknown. Microfilarial destruction can be mediated by antibody to the surface-associated antigens of the worms and enhanced by complement; a correlation exists between the presence of these antibodies and punctate keratitis. Heterogeneous immunologic components are associated with the surface of dermal and nodular microfilariae in vivo. Preliminary findings indicate that the level of O. volvulus-specific immune complexes is inversely proportional to the microfilarial load. To monitor a patient's clinical status and immunologic response, a quantitative system dividing symptoms into those associated with active responses to the microfilariae and those representing long-term consequences of these reactions is suggested.
<i>Nicotiana attenuata</i>SIPK, WIPK, NPR1, and Fatty Acid-Amino Acid Conjugates Participate in the Induction of Jasmonic Acid Biosynthesis by Affecting Early Enzymatic Steps in the Pathway (2009)

Wounding and herbivore attack elicit the rapid (within minutes) accumulation of jasmonic acid (JA) that results from the activation of previously synthesized biosynthetic enzymes. Recently, several regulatory factors that affect JA production have been identified; however, how these regulators affect JA biosynthesis remains at present unknown. Here we demonstrate that Nicotiana attenuata salicylate-induced protein kinase (SIPK), wound-induced protein kinase (WIPK), nonexpressor of PR-1 (NPR1), and the insect elicitor N-linolenoyl-glutamate [corrected] (18:3-Glu) participate in mechanisms affecting early enzymatic steps of the JA biosynthesis pathway. Plants silenced in the expression of SIPK and NPR1 were affected in the initial accumulation of 13-hydroperoxy-linolenic acid (13-OOH-18:3) after wounding and 18:3-Glu elicitation by mechanisms independent of changes in 13-lipoxygenase activity. Moreover, 18:3-Glu elicited an enhanced and rapid accumulation of 13-OOH-18:3 that depended partially on SIPK and NPR1 but was independent of increased 13-lipoxygenase activity. Together, the results suggested that substrate supply for JA production was altered by 18:3-Glu elicitation and SIPK- and NPR1-mediated mechanisms. Consistent with a regulation at the level of substrate supply, we demonstrated by virus-induced gene silencing that a wound-repressed plastidial glycerolipase (NaGLA1) plays an essential role in the induction of de novo JA biosynthesis. In contrast to SIPK and NPR1, mechanisms mediated by WIPK did not affect the production of 13-OOH-18:3 but were critical to control the conversion of this precursor into 12-oxo-phytodienoic acid. These differences could be partially accounted for by reduced allene oxide synthase activity in WIPK-silenced plants.
The Evaluation of Durative Transfusion of Endostar Combined with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer (2018)

Endostar durative transfusion combined with chemotherapy showed a higher DCR, longer PFS and OS time, and was well tolerated in patients with advanced NSCLC.
Application of Cloud Models in Digital Libraries (2007)

In digital libraries, the traditional retrieval methods cannot efficiently retrieve uncertain concepts, and traditional evaluation methods have disadvantages on algorithm measures. To overcome above disadvantages, this paper proposes two new methods based on cloud models. One is to retrieve efficiently uncertain concepts, which can change the granularity of retrieval information. By this method it remarkably improves the recall and precision of information retrieval. Another is to evaluate efficiently retrieval algorithm, which can reflect not only average performance of an algorithm but also stability and randomicity. These two methods set up a transform of qualitative concepts and quantity. This kind of transform is carried out through strict mathematic means. Experimental data showed the method is practical. Results of evaluation will be more accurate and approach to the fact better.
Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction (2008)

Fatal or near-fatal arrhythmias can be predicted by many risk stratification methods, especially by heart rate variability, in patients with reduced LVEF after AMI.
A Diarylquinoline Drug Active on the ATP Synthase of <i>Mycobacterium tuberculosis</i> (2004)

The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis-specific drugs have been discovered in 40 years. We identified a diarylquinoline, R207910, that potently inhibits both drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro (minimum inhibitory concentration 0.06 mug/ml). In mice, R207910 exceeded the bactericidal activities of isoniazid and rifampin by at least 1 log unit. Substitution of drugs included in the World Health Organization's first-line tuberculosis treatment regimen (rifampin, isoniazid, and pyrazinamide) with R207910 accelerated bactericidal activity, leading to complete culture conversion after 2 months of treatment in some combinations. A single dose of R207910 inhibited mycobacterial growth for 1 week. Plasma levels associated with efficacy in mice were well tolerated in healthy human volunteers. Mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase.
Gravity‐induced convective flow in microfluidic systems: Electrochemical characterization and application to enzyme‐linked immunosorbent assay tests (2004)

A way of using gravity flow to induce a linear convection within a microfluidic system is presented. It is shown and mathematically supported that tilting a 1 cm long covered microchannel is enough to generate flow rates up to 1000 nL.min(-1), which represents a linear velocity of 2.4 mm.s(-1). This paper also presents a method to monitor the microfluidic events occurring in a covered microchannel when a difference of pressure is applied to force a solution to flow in said covered microchannel, thanks to electrodes inserted in the microfluidic device. Gravity-induced flow monitored electrochemically is applied to the performance of a parallel-microchannel enzyme-linked immunosorbent assay (ELISA) of the thyroid-stimulating hormone (TSH) with electrochemical detection. A simple method for generating and monitoring fluid flows is described, which can, for instance, be used for controlling parallel assays in microsystems.
Antithrombin-III-Hamilton: a gene with a point mutation (guanine to adenine) in codon 382 causing impaired serine protease reactivity (1988)

Antithrombin-III-Hamilton is a structural mutant of antithrombin III with defective serine protease reactivity, demonstrable in three members of a French Canadian family. The propositus, a 54-year-old man with a history of recurrent thromboembolic events, and his two asymptomatic grown children are heterozygous for the mutant antithrombin III gene. In all three individuals, the immunoreactive antithrombin III level is normal, while the antithrombin and antifactor Xa activity is approximately 50% of the control value. Two dimensional immunoelectrophoresis of antithrombin-III-Hamilton in the presence of heparin is normal. Purified antithrombin-III-Hamilton did not form thrombin-antithrombin III complex when incubated with thrombin for up to 30 minutes. The normal and mutant antithrombin III alleles of the propositus could be distinguished by linkage to Pstl restriction fragment length polymorphisms (RFLP). Genomic DNA from the propositus was cloned into EMBL 3 phage vectors and two clones containing nearly complete copies of the antithrombin-III-Hamilton allele were identified. Exon 6 of both clones was subcloned into M13 phage vector and sequenced, revealing a G----A point mutation in the first base of codon 382. Codon 382 codes for alanine in the normal allele and for threonine in the antithrombin-III-Hamilton allele. Alanine-382, 12 residues from the reactive center, is a highly conserved amino acid in the family of serine protease inhibitors known as the serpins. We postulate that, as a result of the substitution of threonine for alanine in antithrombin-III-Hamilton, either the tertiary structure or the hydrophobicity of the thrombin-binding region is altered, causing aberrant conformation of the Arg-393-Ser-394 bond at the reactive center impairing the interaction between antithrombin-III-Hamilton and the activated serine proteases.
Carvedilol for heart failure: more than just a beta-blocker? (1999)

Carvedilol is a non-selective beta-blocker, and the only one, in recent clinical trials, to have shown a clear reduction in mortality. It is suggested that, compared with other beta-blockers, carvedilol has additional advantageous effects in heart failure, and should be considered as part of the routine treatment of heart failure.
BEHAVIORAL BIASES PADA INDIVIDUAL INVESTOR DI KOTA PALEMBANG (2018)

This study aims to identify and analyze the behavioral biases of individual investors in Palembang City. Data collection techniques used in this study are primary and secondary data taken through interviews, while secondary data obtained through literature literature. The population in this study are all individual investors in Palembang City. The sampling technique using Snowball Sampling and Purposive sampling with the number of samples of 100 respondents. Methods of data analysisÂ starting from the verification of respondents, followed by indepth interviews. The results of the interview were interpreted and analyzed using descriptive statistics. The results concluded that 63% of individual investors in Palembang experienced overconfidence biases, 21% experienced cognitive dissonance biases. 19% experienced Illusion of control biases, 46% experienced regret aversion biases, 73% experienced representative biases, 53% experienced loss aversion biases and 38% experienced mental accounting biases. Keywords : Behavioral Biases, Individual investor
Extended ACTN Architecture to Enable End-To-End 5G Transport Service Assurance (2019)

This paper is aimed to provide a novel approach for an end-to-end service assurance mechanism for 5G back-haul transport network. Abstraction and Control of Traffic Engineered (TE) Networks (ACTN) in an IETF standard architecture enabling virtual network operations to control and manage large-scale multi-domain, multilayer and multi-vendor TE networks, so as to facilitate network programmability, automation, efficient resource sharing. 3GPP 5G requirements calls for Network Slicing support for enhanced mobile broadband (eMBB) and for new `use cases' that require massive machine-type communications (mMTC) and ultra-reliable and low latency communications (URLLC). In order to support these new requirements, the current 3GPP 5G architecture needs to support dynamic instantiation of end-to-end paths that assure traffic classes characterized by network slicing. This paper extends ACTN architecture as well as 3GPP 5G architecture to address service assurance and performance guarantee for an end-to-end 5G backhaul transport networks.
TDMA service for sensor networks (2004)

Sensors networks are often constrained by limited power and limited communication range. If a sensor receives two messages simultaneously then they collide and both messages become incomprehensible. In this paper, we present a simple time division multiple access (TDMA) algorithms for assigning time slots to sensors and show that it provides a significant reduction in the number of collisions incurred during communication. We present TDMA algorithms customized for different communication patterns, namely, broadcast, convergecast and local gossip, that occur commonly in sensor networks. Our algorithms are self-stabilizing, i.e., TDMA is restored even if the system reaches an arbitrary state where the sensors are corrupted or improperly initialized.
Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients (2009)

Differences in gene expression patterns have been documented not only in Multiple Sclerosis patients versus healthy controls but also in the relapse of the disease. Recently a new gene expression modulator has been identified: the microRNA or miRNA. The aim of this work is to analyze the possible role of miRNAs in multiple sclerosis, focusing on the relapse stage. We have analyzed the expression patterns of 364 miRNAs in PBMC obtained from multiple sclerosis patients in relapse status, in remission status and healthy controls. The expression patterns of the miRNAs with significantly different expression were validated in an independent set of samples. In order to determine the effect of the miRNAs, the expression of some predicted target genes of these were studied by qPCR. Gene interaction networks were constructed in order to obtain a co-expression and multivariate view of the experimental data. The data analysis and later validation reveal that two miRNAs (hsa-miR-18b and hsa-miR-599) may be relevant at the time of relapse and that another miRNA (hsa-miR-96) may be involved in remission. The genes targeted by hsa-miR-96 are involved in immunological pathways as Interleukin signaling and in other pathways as wnt signaling. This work highlights the importance of miRNA expression in the molecular mechanisms implicated in the disease. Moreover, the proposed involvement of these small molecules in multiple sclerosis opens up a new therapeutic approach to explore and highlight some candidate biomarker targets in MS.