gebhart/patrepeval huggingface dataset:
Histamine release from human leukocytes by anti-IgE antibodies: influence of multiple or single epitope recognition. (1986)

Upon comparing several polyclonal anti-IgE antisera (specific for the Fc epsilon fragment) for their ability to release histamine, we observed a marked heterogeneity of response for the same antiserum in different cell donors as well as for different antisera in the same cell donor. Additional studies with monoclonal antibodies directed against various epitopes of the D1 and D2 regions revealed several possible explanations: broad specificity of the polyclonal antisera, lack of availability of some epitopes on the cell-bound IgE (which were available on soluble IgE), microheterogeneity among IgE molecules from different patients, and failure of some donors' cells to respond to anti-IgE antibodies. We conclude that selection of appropriate antisera is an important consideration in comparing IgE-mediated histamine release among individuals.
Parallel N log N N-body algorithms and applications to astrophysics (2002)

A parallel version of the Barnes-Hut N-body algorithm is described. The algorithm first assembles a tree data structure which represents the distribution of bodies at all length scales. A domain decomposition is used to assign regions of space and hence bodies to processors. An adaptive load balancing technique is used to insure that processors are assigned equal amounts of work. A tree is built in each processor, and after log/sub 2/ N/sub proc/ exchanges of data, each processor has a restricted version of the tree which is sufficient for force calculations on bodies which lie within its spatial domain. A speedup of over 380 was obtained on a 512-processor Ncube system. Overhead is primarily due to redundant calculation and processor waiting, i.e., the time spent idle waiting for another processor to provide necessary data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Extracellular HMGB1 as a therapeutic target in inflammatory diseases (2018)

High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly after cellular activation, stress, damage or death. HMGB1 operates as one of the most intriguing molecules in inflammatory disorders via recently elucidated signal and molecular transport mechanisms. Treatments based on antagonists specifically targeting extracellular HMGB1 have generated encouraging results in a wide number of experimental models of infectious and sterile inflammation. Clinical studies are still to come. Areas covered: We here summarize recent advances regarding pathways for extracellular HMGB1 release, receptor usage, and functional consequences of post-translational modifications. The review also addresses results of preclinical HMGB1-targeted therapy studies in multiple inflammatory conditions and outlines the current status of emerging clinical HMGB1-specific antagonists. Expert opinion: Blocking excessive amounts of extracellular HMGB1, particularly the disulfide isoform, offers an attractive clinical opportunity to ameliorate systemic inflammatory diseases. Therapeutic interventions to regulate intracellular HMGB1 biology must still await a deeper understanding of intracellular HMGB1 functions. Future work is needed to create more robust assays to evaluate functional bioactivity of HMGB1 antagonists. Forthcoming clinical studies would also greatly benefit from a development of antibody-based assays to quantify HMGB1 redox isoforms, presently assessed by mass spectrometry methods.
A Comprehensive Immunological Analysis in Chronic Fatigue Syndrome (1991)

A detailed analysis of cell-mediated and antibody-mediated immunity was performed in 20 CDC-defined patients with chronic fatigue syndrome (CFS) and 20 age- and sex-matched healthy controls. CD3+, CD4+, CD8+, and CD20+ lymphocytes were comparable in two groups. Natural killer cells as defined by CD16, CD56 and CD57 antigens were significantly reduced in CFS. A significant increase in the proportions of CD4+ ICAM 1+ T cells was observed in CFS. Monocytes from CFS displayed increased density (as determined by mean fluorescence channel numbers) of intercellular adhesion molecule 1 (ICAM-1) and lymphocyte function associated antigen 1 (LFA-1), but showed decreased enhancing response to recombinant interferon-gamma in vitro. The lymphocyte DNA synthesis in response to phytohaemoglobulin (PHA), Concanavalin A (Con A) and pokeweed mitogen (PWM) was normal but the response to soluble antigens was significantly reduced. Serum IgM, IgG, IgA, and IgG subclasses were normal. In vivo specific antibody response to pneumococcus vaccine was depressed in CFS. Forty percent of patients showed titres of anti-human herpes virus 6 (anti-HHV-6) antibody higher than that in the controls (greater than or equal to 1/80). These data suggest immunological dysfunction in patients with chronic fatigue syndrome. The significance of these observations is discussed.
Adaptive DCT coding of video signals (1993)

A coefficient-by-coefficient adaptive discrete cosine transform (DCT) is investigated. The interframe DCT has been known to possess an adverse effect in that it generates mosquito and blocking noise. By analyzing DCT for the intraframe and the interframe video signals, a new adaptive intra/interframe DCT is developed. Cases without and with the movement-compensation are discussed separately. Through simulations, it is shown that a substantial improvement gain (1.0-5.0 dB/sub p-p/ or 0.2-2.0 dB/sub p-p/, respectively) can be obtained by the new adaptive method. The improvement is brought about by the reduction of the blocking noise conventionally generated by the coarse quantization of the higher order interframe DCT coefficients. By calculating the improvement bound, a further possibility is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Examination of Binder Systems and Their Influences on Burn Rates of High‐Nitrogen Containing Formulations (2011)

Abstract The examination of Laminac 4116/Lupersol and Epon 813/Versamid 140 binder systems, and their influences on burn rates of pyrotechnic formulations is described. Laminac 4116/Lupersol‐based formulations had shorter burn times and larger heat of explosion values compared to their Epon 813/Versamid 140 counterparts. An understanding of the chemical structures and approximate oxygen balances of these binder systems served to explain their burn time differences when used in pyrotechnic formulations. Bomb calorimetry of Laminac 4116/Lupersol‐ and Epon 813/Versamid 140‐based formulations provided heat of explosion values to further explain the burn time differences of the two binder systems used.
Characterization of the human patatin-like phospholipase family (2006)

Several publications have described biological roles for human patatin-like phospholipases (PNPLAs) in the regulation of adipocyte differentiation. Here, we report on the characterization and expression profiling of 10 human PNPLAs. A variety of bioinformatics approaches were used to identify and characterize all PNPLAs encoded by the human genome. The genes described represent a divergent family, most with a highly conserved ortholog in several mammalian species. In silico characterization predicts that two of the genes function as integral membrane proteins and are regulated by cAMP/cGMP. A structurally guided protein alignment of the patatin-like domain identifies a number of conserved residues in all family members. Quantitative PCR was used to determine the expression profile of each family member. Affymetrix-based profiling of a human preadipocyte cell line identified several members that are differentially regulated during cell differentiation. Cumulative data suggest that patatin-like genes normally expressed at very low levels are induced in response to environmental signals. Given the observed conservation of the patatin fold and lipase motif in all human PNPLAs, a single nomenclature to describe the PNPLA family is proposed.
Telomerase Activity in Human Benign Prostate Tissue and Prostatic Adenocarcinomas (1997)

Telomerase adds a hexanucleotide telomeric sequence to the chromosomal ends during replication and is postulated to play a role in cellular senescence and immortalization. Thirty-four human prostate tissues (18 malignant; 16 benign) were analyzed for telomerase activity by a sensitive nonradioactive polymerase chain reaction (PCR)-based method using the TRAP-eze telomerase detection kit (Oncor, Inc., Gaithersburg, MD). Telomerase activity in the homogenized tissue extracts was correlated with tumor grade, pathologic stage, and DNA ploidy. Specimens that exhibited the 36 bp internal control band and a ladder of products with 6-base increments starting with 50 nucleotides were considered positive. Fourteen (78%) of 18 prostatic adenocarcinomas (PACs) and only 2 (13%) of 16 benign prostate tissues exhibited telomerase activity. Our results indicate that, in contrast to most benign prostate tissues, telomerase activity can be detected in the majority of PACs and appears to be independent of tumor grade, stage, or DNA ploidy. Telomerase expression is occasionally detected in benign prostatic tissues bordering PACs and may result from either the presence of undetected tumor foci in these stored specimens or the proliferative response of the benign elements to adjacent cancer.
Collective patterns and decision-making (1989)

Autocatalytic interactions between the members of an animal group or society, and particularly chemically or visually mediated allelomimesis, can be an important factor in the organisation of their collective activity. Furthermore, the interactions between the individuals and the environment allow different collective patterns and decisions to appear under different conditions, with the same individual behaviour. While most clearly demonstrable in social insects, these principles are fundamental to schools of fishes, flocks of birds, groups of mammals, and many other social aggregates. The analysis of collective behaviour in these terms implies detailed observation of both individual and collective behaviour, combined with mathematical modelling to link the two.
Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene (2018)

This work was funded by K08 HL123940 to JMW; R01HL124233 to PJC; Merit Review I01 CX000911 to JLC; R01 (R01HL102371, R01HL126596) and VA Merit (I01BX001756) to AG. SPIROMICS (Subpopulations and Intermediate Outcomes in COPD Study) is funded by contracts from the NHLBI (HHSN268200900013C, HHSN268200900014C,HHSN268200900015C HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C, and HHSN268200900020C) and a grant from the NIH/NHLBI (U01 HL137880), and supplemented by contributions made through the Foundation for the NIH and the COPD Foundation from AstraZeneca/MedImmune; Bayer; Bellerophon Therapeutics; Boehringer-Ingelheim Pharmaceuticals Inc.; Chiesi Farmaceutici; Forest Research Institute Inc.; GlaxoSmithKline; Grifols Therapeutics Inc.; Ikaria Inc.; Novartis Pharmaceuticals Corporation; Nycomed GmbH; ProterixBio; Regeneron Pharmaceuticals Inc.; Sanofi; Sunovion; Takeda Pharmaceutical Company; and Theravance Biopharma and Mylan. COPDGene is funded by the NHLBI (R01 HL089897 and R01 HL089856) and by the COPD Foundation through contributions made to an Industry Advisory Board composed of AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Novartis, Pfizer, Siemens, and Sunovion.
Texture element feature characterizations for CBIR (2005)

Colour and texture are the most common features used in CBIR systems today. In this paper, we wish to investigate structural methods of texture analysis for CBIR in view of their closeness to human perception and description of texture. In structural analysis, local patterns are the key (as is the case with humans), and when used as features may be expected to return more relevant images in CBIR. One method to describe local patterns in computationally simple terms is texture spectrum proposed by He and Wang. In this paper, we propose two additional characterizations of local patterns. The first is an extension of He and Wang's texture spectrum to larger and more meaningful windows, along with new structural features that capture local patterns such as horizontal and vertical stripes, alternating dark and bright spots, etc. The second is a new method that characterizes patterns as contrast variations in 5 /spl times/ 5 windows. We apply the new texture characterizations to develop a CBIR application and tested their performance on two databases containing remote sensing images. Our results show accuracies that range from 60% to 100% depending on the query image and the features contained therein. These results indicate that our texture features are useful in retrieving images appropriate for different remote sensing applications.
Generation of mouse ES cell lines engineered for the forced induction of transcription factors (2011)

Here we report the generation and characterization of 84 mouse ES cell lines with doxycycline-controllable transcription factors (TFs) which, together with the previous 53 lines, cover 7-10% of all TFs encoded in the mouse genome. Global gene expression profiles of all 137 lines after the induction of TFs for 48 hrs can associate each TF with the direction of ES cell differentiation, regulatory pathways, and mouse phenotypes. These cell lines and microarray data provide building blocks for a variety of future biomedical research applications as a community resource.
α-Naphthol sorption as regulated by structure and composition of organic substances in soils and sediments (1996)

Humic acids (HAs) from major horizons of a Gleyed Black Chernozem and a set of soil and sediment samples were examined to understand the influence of the structure a composition of organic substances on sorption of organic pollutants. Solid state 13 C cross-polarized/magic angle spinning (CP/MAS) NMR results indicated that the aromaticity of HAs increased with soil depth. The aromaticity of organic substances in bulk soils and sediments varied with the degree of geological diagenesis. Sorption experiments showed a linear relationship between the carbon normalized partition coefficient (K oc ) of α-naphthol and the aromaticity of HAs and non-extracted organic substances in whole soils and sediments. The K oc values of α-napthol had a log-linear relationship with the atomic mass ratio (N+O)/C of the organic substances in soils and sediments. Correlation analysis for the literature data further revealed that the compositional and structural properties of organic substances were related, suggesting possibilities of predicting K oc with either compositional or structural parameters Measured K oc values demonstrated considerable deviations from those calculated with prediction models using K ow . The prediction models may not be accurate because they do not account for the compositional and structural differences in organic substances of sorbents. Key words: sorption, organic substances, aromaticity, K oc , α-naphthol
Increasing user interaction during high-level synthesis (1991)

Article Free Access Share on Increasing user interaction during high-level synthesis Authors: Robert A. Walker Computer Science Department, Rensselaer Polytechnic Institute, Troy, NY Computer Science Department, Rensselaer Polytechnic Institute, Troy, NYView Profile , Shivkumar Ramabadran Electrical, Computer and Systems Engineering Dept., Rensselaer Polytechnic Institute, Troy, NY Electrical, Computer and Systems Engineering Dept., Rensselaer Polytechnic Institute, Troy, NYView Profile , Rajive Joshi Electrical, Computer and Systems Engineering Dept., Rensselaer Polytechnic Institute, Troy, NY Electrical, Computer and Systems Engineering Dept., Rensselaer Polytechnic Institute, Troy, NYView Profile , Steinar Flatland Computer Science Department, Rensselaer Polytechnic Institute, Troy, NY Computer Science Department, Rensselaer Polytechnic Institute, Troy, NYView Profile Authors Info & Claims MICRO 24: Proceedings of the 24th annual international symposium on MicroarchitectureSeptember 1991 Pages 133–142https://doi.org/10.1145/123465.123493Online:01 September 1991Publication History 3citation180DownloadsMetricsTotal Citations3Total Downloads180Last 12 Months4Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
옥천천(만) 유역 하천과 만입부의 수환경 평가 (2003)

옥천천(만)유역을 대상으로 2002년 5월부터 9월까지 총 6회 수환경을 조사하였다. 환경 요인은 하천과 구간에 따라 차이가 컸고, 유수환경과 정수환경에서 더욱 현저하여 대비가 되었다. 수중 영양염은 상류 하천에서 비교적 저농도이었으나, 하수처리수 유입 후부터 고농도로 전한되어 점오염원 영향이 절대적이었다. 특히, 유역에서 SRP와 NH_4의 분포는 다른 영양염에 비해 매우 뚜렷하였고, 하수처리수의 영향을 평가함에 있어 가장 중요한 인자가 될 수 있었다. 하수처리수의 유입직 후 정점에서 SRP의 평균 농도는 919.3㎍ P/l로써 유역에서 가장 영향력이 컸고, P 농도에 의해 수중 영양염 비율이 조절됨을 알 수 있었다. 하수처리수의 지속적 공급은 하류의 만입부에서 chl-α 증가를 유도하는 결정적인 요인으로 볼 수 있었다. 남조류가 대발생한 시기에 만입부에서 chl-α 농도는 234.5~1,692.2㎍/l 범위이었고, 8월에 최대 현존량 ml당 1.0×10^6 세포를 훨씬 초과하여 담수적소 수준보다 200배 이상이었다. 이러한 결과는 다른 환경요인에서 잘 반영되었고, 그중에서 AFDM/TSS 비는 100%로써 조류에 의한 수질오염이 극심함을 잘 반영하였다. 따라서, 하수처리수에 포함된 P와 N 선행되어야 하천 수환경 개선 뿐만 아니라 저수지 수질 관리에 효과가 있을 것으로 본다.
Vpliv tlačnih utripanj v sesalni cevi na dinamiko kavitacijskega vrtinca v francisovi turbini (2003)

The influence of pressure pulsations on the cavitation-vortex dynamics in a Francis-turbine draft tube is presented. The experiment was performed on a model Francis turbine in which pressure pulsations on the draft-tube wall and the cavitation-vortex dynamics were acquired simultaneously. The cavitation-vortex dynamics was recorded using a visualization method. An experimental model was proposed in which the cavitation-vortex dynamics was predicted based on recorded pressure information at one point on the draft-tube wall. The performance of the model is, on average, very good. The prediction of the cavitation-vortex dynamics shows better results when the distance between the pressure sensor and the cavitation vortex is short.
Transform-limited optical short-pulse generation at high repetition rate over 40 GHz from a monolithic passive mode-locked DBR laser diode (1993)

The fabrication of monolithic InP-based passively mode-locked distributed-Bragg-reflector (DBR) laser is reported. An optical short-pulse train with a duration of 3.5 ps was generated at a repetition rate of over 40 GHz. The time-bandwidth product was 0.43, and it was very close to the transform-limited value of a Gaussian waveform. Peak power of 60 mW has been achieved. This laser is promising as an optical source for a high-bit-rate soliton transmission system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Inhibition of T helper 2‐type responses, IgE production and eosinophilia by synthetic lipopeptides (2003)

In allergy and asthma, the fine balance between the T helper (Th) 1, Th2 and T regulatory cytokine responses appears to be shifted towards Th2. Here, we report that synthetic lipopeptides which contain the typical lipid part of the lipoprotein of gram-negative bacteria stimulate a distinct regulatory cytokine pattern and inhibit several Th2 cell-related phenomena. The most potent analogue of synthetic lipopeptides, lipopeptide CGP 40774 (LP40) was not active in MyD88-deficient mice and stimulated Toll-like receptor (TLR)-2, but not TLR-4. LP40 potentiated the production of IFN-gamma and IL-10, but not IL-4 and IL-5 by human T cells. In addition, triggering of TLR-2 by lipopeptides promoted the in vitro differentiation of naive T cells towards IL-10- and IFN-gamma-producing T cells and suppressed IL-4 production by Th2 cells. Accordingly, LP40 inhibited IgE production induced by allergen, anti-IgD antibody, Nippostrongylus brasiliensis or murine acquired immunodeficiency virus. Furthermore, ovalbumin-induced lung eosinophilic inflammation was abolished and Schistosoma mansoni egg-induced granuloma size and eosinophil counts were suppressed in mice by LP40. These results demonstrate that stimulation of TLR-2 by lipopeptides represents a novel way for possible treatment of allergy and asthma by regulating the disrupted cytokine balance.
Two 3,4-seco-Lupane Triterpenes from Leaves of Acanthopanax divaricatus var. albeofructus. (2000)

Two 3,4-seco-lupane triterpenoids (1, 2) were isolated from the leaves of Acanthopanax divaricatus var. albeofructus (Araliaceae). Based on the spectroscopic data, the chemical structures of 1 and 2 were characterized as 24-hydroxychiisanogenin and 22alpha-hydroxychiisanogenin, respectively. 1 was a new compound and 2 was isolated for the first time from the natural source, although it had been obtained as an enzymatically hydrolyzed artifact from 22alpha-hydroxychiisanoside.
Interfacial Strength and Physical Properties of Functionalized Graphene - Epoxy Nanocomposites (2006)

The toughness and coefficient of thermal expansion of a series of functionalized graphene sheet - epoxy nanocomposites are investigated. Functionalized graphene sheets are produced by splitting graphite oxide into single graphene sheets through a rapid thermal expansion process. These graphene sheets contain approx. 10% oxygen due to the presence of hydroxide, epoxide, and carboxyl functional groups which assist in chemical bond formation with the epoxy matrix. Intrinsic surface functionality is used to graft alkyl amine chains on the graphene sheets, and the addition of excess hardener insures covalent bonding between the epoxide matrix and graphene sheets. Considerable improvement in the epoxy dimensional stability is obtained. An increase in nanocomposite toughness is observed in some cases.
Oxidative Dehydrogenation of Ethane on Dynamically Rearranging Supported Chloride Catalysts (2014)

Ethane is oxidatively dehydrogenated with a selectivity up to 95% on catalysts comprising a mixed molten alkali chloride supported on a mildly redox-active Dy2O3-doped MgO. The reactive oxyanionic OCl(-) species acting as active sites are catalytically formed by oxidation of Cl(-) at the MgO surface. Under reaction conditions this site is regenerated by O2, dissolving first in the alkali chloride melt, and in the second step dissociating and replenishing the oxygen vacancies on MgO. The oxyanion reactively dehydrogenates ethane at the melt-gas phase interface with nearly ideal selectivity. Thus, the reaction is concluded to proceed via two coupled steps following a Mars-van-Krevelen-mechanism at the solid-liquid and gas-liquid interface. The dissociation of O2 and/or the oxidation of Cl(-) at the melt-solid interface is concluded to have the lowest forward rate constants. The compositions of the oxide core and the molten chloride shell control the catalytic activity via the redox potential of the metal oxide and of the OCl(-). Traces of water may be present in the molten chloride under reaction conditions, but the specific impact of this water is not obvious at present. The spatial separation of oxygen and ethane activation sites and the dynamic rearrangement of the surface anions and cations, preventing the exposure of coordinatively unsaturated cations, are concluded to be the origin of the surprisingly high olefin selectivity.
Clinical pharmacokinetics of terbinafine (Lamisil) (1989)

Journal Article Clinical pharmacokinetics of terbinafine (Lamisil) Get access J.C. JENSEN J.C. JENSEN Human Pharmacology Department, Drug Safety Assessment, Sandoz Ltd, 4002 Basel, Switzerland J.C.Jensen, Human Pharmacology Department, Drug Safety Assessment, Sandoz Ltd., 4002 Basel, Switzerland. Search for other works by this author on: Oxford Academic Google Scholar Clinical and Experimental Dermatology, Volume 14, Issue 2, 1 March 1989, Pages 110–113, https://doi.org/10.1111/j.1365-2230.1989.tb00904.x Published: 01 March 1989 Article history Accepted: 21 September 1988 Published: 01 March 1989