gebhart/patrepeval huggingface dataset:
S-band fiber optic amplifiers (2002)

This paper reviews S-band fiber optic amplifiers including thulium-doped fiber amplifiers (TDFA), gain-shifted thulium-doped fiber amplifiers and Raman amplifiers describe TDFA, gain shifted (GS) TDFA and Raman amplifiers. The TDFAs or GS-TDFA seem to have a slight advantage over Raman amplifiers in terms of power conversion efficiency, but we must make further improvements in power conversion efficiency if we wish to employ all these amplifiers under practical conditions.
Influence of treatment with the immunomodulatory effective dose of the beta-galactoside-specific lectin from mistletoe on tumor colonization in BALB/c-mice for two experimental model systems. (1991)

Mistletoe extracts have approval for clinical application. This warrants the quest for the definition of the active substances to optimize their application. Thus, the extent of immunomodulating and antimetastatic activity of the beta-galactoside-specific lectin from mistletoe extract (ML I) was investigated. In BALB/c-mice regular subcutaneous (s.c.) injections of small nontoxic doses of ML I yielded significant enhancement of peritoneal macrophage activity, as measured in chemiluminescence assays, as well as significant weight gain of thymus. Spleen weight, however, increased without statistical significance. To evaluate the anti-metastatic activity of ML I we intravenously (i.v.) inoculated sarcoma L-1 and fibrosarcoma RAW 117-H 10 cells which cause tumor colonization of lungs and livers in BALB/c-mice, respectively. After regular s.c. administration of ML I, the number of lung and liver tumor colonies significantly decreased in both experimental tumor models as compared to control mice which received injections of saline solution. Accordingly, ML I can be regarded as a potent immunomodulating and antimetastatic substance, which seems to be promising for clinical trials in human oncology.
Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes. (1994)

Mice homozygous for the piebald lethal (sl) mutation have a predominantly white coat due to the absence of neural crest-derived melanocytes in the hair follicles. To investigate the time in embryonic development when the s1 gene affects the melanocyte lineage, we compared the distribution of melanocyte precursors in wild-type and mutant embryos, using an antibody specific for tyrosinase-related protein 2 (TRP-2). TRP-2 positive cells were first observed adjacent to the anterior cardinal vein in 10.5-day postcoitem wild-type embryos. From 11.5 to 13.5 days postcoitem, there was a nonuniform distribution of TRP-2 positive cells along the anterior-posterior axis, with the highest density of cells in the head and tail regions. Along the dorsal-ventral axis, the cells were restricted to positions lateral, but never dorsal, to the neural tube. In homozygous sl/sl embryos TRP-2 staining was restricted to the non-neural crest-derived melanocytes of the pigmented retinal epithelium and the telencephalon. Few positive cells were seen in areas that will form neural crest-derived melanocytes in the inner ear, skin, hair follicles, leg musculature, or heart. We conclude that the piebald lethal mutation acts prior to the onset of TRP-2 expression to disrupt the development of neural crest-derived melanocytes. The non-uniform distribution of melanoblasts in wild-type mice suggests that piebald acts stochastically to affect melanocyte development.
Issue of the moment (1990)

Current media attention to the Graham Pink case has implied that nursing academics and researchers (among others) fail to get involved in the issues of the moment, namely the struggle for resources and power. As a result, it is claimed, informed commentary from this section of the nursing community is noteable by its absence.
The Safety of Intraocular Ketorolac in Rabbits (2006)

Preservative-free ketorolac tromethamine is nontoxic to the retinas of rabbits when injected intravitreally and could be considered as an alternative to intraocular steroid injections.
Ultrasound-modulated optical tomography using four-wave mixing in photorefractive polymers (2008)

Ultrasound-modulated optical tomography uses a well focused ultrasound beam to modulate diffuse light inside soft biological tissues. This modality combines the advantages of ultrasound resolution with optical contrast. However, because of the low ultrasound modulation efficiency, the large background of un-modulated photons gives a low signal-to-noise ratio. Here we report a technique for detection of ultrasound-modulated light using a phase conjugated signal generated by four-wave mixing in a photorefractive polymer. The experimental results demonstrate the potential of this method to detect ultrasound-modulated optical signals in a highly scattering media with an excellent signal-to-noise ratio.
Treatment of intact striatal neurones with cholera toxin or 8‐bromoadenosine 3′,5′‐(cyclic)phosphate decreases the ability of pertussis toxin to ADP‐ribosylate the α‐subunits of inhibitory and other guanine‐nucleotide‐binding regulatory proteins, G<sub>i</sub> and G<sub>o</sub> (1991)

Using primary cultures of striatal neurones from the mouse embryo, we showed that treatment of intact cells with cholera toxin (5 micrograms/ml, 22 h) decreases the subsequent ADP-ribosylation of the alpha subunit of the guanine-nucleotide-binding regulatory protein Go (Go alpha) and the alpha subunit of the inhibitory guanine-nucleotide-binding regulatory protein (Gi alpha) of adenylate cyclase, which is catalyzed in vitro on neuronal membranes by pertussis toxin. The inhibitory effect of cholera toxin could not only be attributed to an increased production of cAMP in neurones. Treatment of cells with 0.1 microM 8-bromoadenosine 3',5'-(cyclic)phosphate (BrcAMP) for 16 h, or with 0.1 mM BrcAMP for 5 min, mimicked the effect of cholera toxin on the ADP-ribosylation of Go alpha and Gi alpha in vitro. However, the two agents seem to act through distinct mechanisms. The protein kinase inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine prevented the action of Br8cAMP but not that of cholera toxin. In addition, measurements of the pI of the Go alpha deduced from immunoblots of two-dimensional gels performed using a specific antibody directed against Go alpha suggest that treatment of neurones with cholera toxin induces ADP-ribosylation of Go alpha in intact cells, while BrcAMP does not.
Advanced Analysis Identifies Greater Efficiency for Testing BOPs in Deep Water (2005)

Summary Pressure testing blowout preventers (BOPs) with synthetic-based mud (SBM) requires lengthy testing times resulting from pressure/volume/temperature (PVT) influences associated with SBM. PVT influences are especially pronounced indeep water and high-pressure test environments. A project was initiated in an effort to better understand the mechanics that transpired during BOP testing. The primary objective was to demonstrate that the pressure decline was quantified by the fluid-PVT behavior, mechanical influences and thermodynamics of pressurization, and subsequent cool down. The secondary objective was to demonstrate that the pressure decline resulting froma leak could be reliably and efficiently detected with high-resolution pressure data. It was theorized that the gradual decay of pressure during the shut-in phase was a result of the heat added to the system during pressurization. To pursue this investigation, real-time PVT data were gathered at the cementing-unit (CU)suction and discharge while testing the BOP. In addition, pressure/temperature(P/T) gauges were placed in the drillstring—one at the drill floor, one at the midpoint between the drill floor and the BOP, and one above the BOP stack. The gauges confirmed significant heat up as the system was pressured up for each test. The pressure decreased as the system cooled back toward the ambient temperature. Modeling techniques were developed to understand the system response. This paper presents salient aspects of data acquisition, data interpretation, and modeling techniques. Results demonstrate the potential to significantly impact the industry, with respect to safety, time, and costs for BOP testing.
4D-Bestrahlungsplan für intrafraktionelle Organbewegungen in der Strahlentherapie (2007)

Die dreidimensionale (3D) computergestützte Bestrahlungsplanung ist gegenwärtig der Standard in der Strahlentherapie. Als Grundlage dient ein einzelnes Planungs-CT, das die Risikoorgane und das Zielvolumen (ZV) vollständig beinhalten muss. Insbesondere in Brust- und Bauchraum werden aber durch Atmung, Herzschlag und Peristaltik Bewegungen an Zielvolumen und Organen verursacht. Ein einzelner CT-Scan ist eine willkürliche Momentaufnahme der Lage von Zielvolumen und Organen und darf keineswegs als deren mittlere Position aufgefasst werden. Um ein atmungs-induziertes Herausdriften des ZV aus dem Bestrahlungsfeld zu verhindern, ist der Radioonkologe gezwungen, einen entsprechend großzügigen Sicherheitssaum um das zu bestrahlende klinische Zielvolumen herumzulegen. Die meisten Strahlentherapieabteilungen sind technisch nicht in der Lage, die ZV-Bewegungen individuell zu bestimmen und arbeiten für die unterschiedlichen Tumoren mit Standardsicherheitssäumen, denen mittlere Bewegungsamplituden aus der Literatur zugrunde liegen. Damit wird das letztlich zu bestrahlende Zielvolumen erheblich vergrößert, radiotoxische Nebenwirkungen (z.B. Lungenfibrose) können die Folge sein. Um die Dynamik eines Tumors oder Organs in allen drei Raumrichtungen studieren zu können, sind eine ap-Durchleuchtung (Therapiesimulator) für die cranio-caudale Bewegung und ein zeitabhängiger CT-Datensatz (4D-CT) für die beiden lateralen Bewegungsrichtungen erforderlich. Bei einem 4D-CT wird zeitgleich mit dem CT-Scan auch eine Atmungskurve mit einem externen Marker aufgenommen. Grundsätzlich werden zwei Vorgehensweisen unterschieden, das prospektive und retrospektive 4D-CT. Beim prospektiven 4D-CT werden nur Schnittbilder angefertigt, wenn sich der Atmungszyk-lus des Patienten in einer vorher definierten bestimmten Phase befindet. Auf der Grundlage dieses CT's wird dann der Bestrahlungsplan erstellt und der Beschleuniger wird mit dem ex-ternen Marker als Signalgeber für die festgelegte Atmungsphase getriggert. Beim retrospek-tiven 4D-CT wird hingegen ein Satz an CT-Schnittbildern über mindestens einen vollständi-gen Atmungszyklus generiert, von denen jedes einzelne Schnittbild seiner Phase der At-mungskurve nach dem Scan zugeordnet werden kann. Eine Anzahl von 5 CT-Schnittbildern einer Position wird für einen Atmungszyklus als ausreichend angesehen.
Evaluating the effect of voting methods on ensemble-based classification (2017)

Bagging is a popular method used to increase the accuracy of classification, by training a set of classifiers on slightly different datasets and aggregating their output by voting. Usually, the majority voting is used for this purpose, or the plurality voting, when the problem has multiple class values. In this study, we analyze the influence of several voting methods on the performance of two classification algorithms used for datasets with different levels of difficulty. The results reveal that the single transferable vote can be a good alternative to plurality voting, although it has the drawback of a higher computational cost related to the calculation of preference ordering.
Analysis of Biohydrogen Production Potential from Organic Wastes Generated in Korea (2021)

Objectives : To mitigate greenhouse gas (GHG) emissions, our country is trying to replace fossil fuel to hydrogen (H2). H2 has higher energy yield (122 MJ/kg) than other energy sources (natural gas, coal, etc.), and is considered a clean fuel that produces only water upon combustion. The water electrolysis using renewable energy is one of the green-H2 producing methods, but its unstable characteristics depending on weather condition impede its practical application. Therefore, to establish green-H2 society, the use of waste and biomass is essential to fulfil the demand.Methods : In this study, we estimated the biohydrogen potential of organic solid wastes: food waste, livestock manure, and sewage sludge, which are the main feedstock of domestic biogas plant. For the H2 generation process, dark fermentation (DF) and steam biogas reforming (SBR) were considered.Results and Discussion : The potential amount of H2 through DF and SBR was 44,000 ton/y and 675,000 ton/y, respectively. The GHG reducing potential was estimated to be 5 million tons CO2-eq/year, but it can be lowered down to 2 million tons CO2-eq/year, considering the energy consumption during H2 generation process. Among the energy potential of produced H2, 7% and 60% is required for H2 production in DF and SBR, respectively.Conclusion The expected biohydrogen production was 718,000 ton/y which can account for about 14% of the domestic H2 production target in 2040 (526 million tons). The main source was livestock manure (86%), and minor fraction was from food waste (10%), and sewage sludge (4%). The GHG reducing potential was estimated to be 2 million tons CO2-eq/year, considering the energy consumption during H2 generation process.
Filamentation by<i>Escherichia coli</i>subverts innate defenses during urinary tract infection (2006)

To establish disease, an infecting organism must overcome a vast array of host defenses. During cystitis, uropathogenic Escherichia coli (UPEC) subvert innate defenses by invading superficial umbrella cells and rapidly increasing in numbers to form intracellular bacterial communities (IBCs). In the late stages of the IBC pathway, filamentous and bacillary UPEC detach from the biofilm-like IBC, fluxing out of this safe haven to colonize the surrounding epithelium and initiate subsequent generations of IBCs, and eventually they establish a quiescent intracellular reservoir. Filamentous UPEC are not observed during acute infection in mice lacking functional Toll-like receptor 4 (TLR4), suggesting that the filamentous phenotype arises in response to host innate immunity. We investigated SulA, a cell division inhibitor associated with the SOS response, to gain insight into the role of filamentous UPEC in pathogenesis. A transcriptional reporter from P(sulA) revealed spatial and temporal differences in expression within IBCs, and it was active in the majority of filamentous UPEC. Although UTI89 and UTI89 DeltasulA both formed first-generation IBCs equally well, UTI89 DeltasulA was sharply attenuated in formation of second-generation IBCs and establishment of the quiescent intracellular reservoir. The virulence of UTI89 DeltasulA was restored in TLR4-deficient mice, suggesting that filamentation facilitates the transition to additional rounds of IBC formation by subverting innate immune responses. These findings demonstrate that transient SulA-mediated inhibition of cell division is essential for UPEC virulence in the murine model of cystitis.
Advances in the diagnosis and classification of gastric and intestinal motility disorders (2018)

Disturbances of gastric, intestinal and colonic motor and sensory functions affect a large proportion of the population worldwide, impair quality of life and cause considerable health-care costs. Assessment of gastrointestinal motility in these patients can serve to establish diagnosis and to guide therapy. Major advances in diagnostic techniques during the past 5-10 years have led to this update about indications for and selection and performance of currently available tests. As symptoms have poor concordance with gastrointestinal motor dysfunction, clinical motility testing is indicated in patients in whom there is no evidence of causative mucosal or structural diseases such as inflammatory or malignant disease. Transit tests using radiopaque markers, scintigraphy, breath tests and wireless motility capsules are noninvasive. Other tests of gastrointestinal contractility or sensation usually require intubation, typically represent second-line investigations limited to patients with severe symptoms and are performed at only specialized centres. This Consensus Statement details recommended tests as well as useful clinical alternatives for investigation of gastric, small bowel and colonic motility. The article provides recommendations on how to classify gastrointestinal motor disorders on the basis of test results and describes how test results guide treatment decisions.
Intratypic Variants of HPV-16 E6jE7 Oncogene Isolated from Sexually High-Risk Women in Busan. (2009)

HPV-16형의 염기배열 변이는 지역적, 인종적으로 특징적인 차이가 있으며 특히 HPV-16형 E6/E7 유전자의 특정 염기 서열변이는 자궁경부암 및 자궁상피내 신생종양물의 발생을 일으키는 고위험 요인으로 알려져 있다. 본 연구는 2007년 부산지역 유흥업소 종사여성으로 분리된 HPV-16형 19건을 대상으로 E6/E7 유전자 영역(nt 34-880)을 표적으로 지역적 염기 서열 변이를 조사하였다. nucleotide 수준에서 HPV16형 E6 유전자는 T178G (n=11), T178A (n=1), T350G (n=4), A442C (n=2), A104T, A111G, C116T, G145T, T183G, C335T, G522C 등 11종의 변이주가 발견되었고, E7 유전자는 A647G (n=12), A645C, A777C, G663A, T732C, T760C, A775T, T789C, T795G 등 9종의 변이주가 발견되었다. 아미노산 수준에서는 HPV-16형 E6 단백질의 경우 D25E (n=12), L83V (n=4), E113D (n=2), MIL, Q3R, P5S, Q14H, D25N, 127R, H78Y, C140S 등 11종의 변이주를, HPV16형 E7 단백질의 경우 N29S (n=12), L28F, T72S 등 3종의 변이주를 관찰할 수 있었다. 본 연구 결과, 부산지역의 HPV-16형 E6/E7 우점 돌연변이주는 E6 D25E (75%), E7 N29S (78%)로 각각 나타났다. 앞으로 자궁경부암 환자 및 일반여성을 포함한 더 많은 모집 단을 대상으로 HPV-16형 E6/E7의 intratypic variants를 비교 조사하여 실제 HPV-16형 E6/E7 어떤 변이주가 자궁경부암 유발 위험성과의 관련성은 더 많이 연구되어져야 할 것으로 사료된다. Recent studies have reported that the distribution of HPV-16 sequence variation differs geographically, and more specifically that HPV-16 E6/E7 intratypic variants might carry a high risk for development of ICC (invasive cervical cancer) and CIN (cervical intraepithelial neoplasia) in a given population. To investigate the genetic diversities of HPV-16 E6/E7 oncogene by region, we collected nineteen HPV-16 isolates from sexually high-risk women in Busan, and analyzed the HPV-16 E6/E7 coding regions (nt 34 to 880) with HPV-16 E6/E7 specific PCR amplification. At the nucleotide levet eleven variants of the E6 genes and nine variants of the E7 genes were identified as follows: E6 T178G (n=l1), E6 T178A (n=l), E6 T350G (n=3), E6 A442C (n=2), E6 AI04T, E6 All1G, E6 C116T, E6 G145T, E6 T183G, E6 C335T, E6 G522C and E7 A647G (n=12), E7 A645C, E7 A777C, E7 G663A, E7 T732C, E7 T760C, E7 A775T, E7 T789C and E7 T795G, respectively. At the amino acid levet the isolated HPV-16 E6 and E7 genes showed eleven E6 variants: E6 D25E (n=12), E6 L83V (n=4), E6 E113D (n=2), E6 MIL, E6 Q3R, E6 P5S, E6 Q14H, E6 D25N, E6 127R, E6 H78Y, E6 C140S and three E7 variants: N29S (n=12), L28F, T72S. HPV16 E6 L83V, the dominant variant in the Caucasian population, showed relatively low frequencies in our study population. We elucidated that the dominant HPV-16 E6/E7 variants were HPV-16 E6 D25E (63.2%) and HPV-16 E7 N29S (63.2%), which were phylogenetically included in Asian lineage. Further study is needed to evaluate the risk of cervical cancer related HPV-16 E6/E7 intratypic variants in the Korean population.
ChemInform Abstract: Heterostructures of Single‐Walled Carbon Nanotubes and Carbide Nanorods. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Activation of Pyk2/RAFTK induces tyrosine phosphorylation of α‐synuclein via Src‐family kinases (2002)

alpha-Synuclein (alpha S) is a neuronal protein that has been implicated in the pathogenesis of Parkinson's disease. The present report demonstrates that the protein tyrosine kinase Pyk2/RAFTK is involved in cell stress-induced tyrosine phosphorylation of alpha S. Hyperosmotic stress induced tyrosine phosphorylation of alpha S via Pyk2/RAFTK at tyrosine residue 125. Pyk2/RAFTK-mediated phosphorylation of alpha S was primarily achieved with Src-family kinases. In addition, osmotic stress-induced phosphorylation of alpha S was dependent on Pyk2/RAFTK activation. Accordingly, such results indicate that Pyk2/RAFTK lies upstream of Src-family kinases in the signaling cascade by which osmotic stress induces tyrosine phosphorylation of alpha S.
Prediction of sotalol-induced maximum steady-state QTc prolongation from single-dose administration in healthy volunteers (1992)

The relationship between racemic sotalol plasma concentrations and QTc interval prolongation after both single-dose and repeated administration of three sotalol oral doses was studied in a randomized crossover protocol performed in 10 healthy volunteers. QTc interval increase was significant after the three single-dose sotalol administrations and was significantly related to the administered dose (p < 0.0001). In 21 of 30 analyses, QTc interval was linearly correlated with sotalol plasma concentrations. After the 320 mg dose, the linear model was a best fit for 90% of the cases, and no hysteresis was observed. After repeated sotalol administration, 69 of 87 QTc interval measurements at steady state could be predicted from the plasma concentration versus effect relationship established after single-dose 320 mg administration. Seventeen of 18 errors (94%) corresponded to QTc intervals that were significantly lower than predicted. These findings suggest that a short-term individual linear model determined after a 320 mg test dose of sotalol allows a good prediction of expected maximal increase in QTc duration in healthy subjects.
RF characteristics of thin film liquid crystal polymer (LCP) packages for RF MEMS and MMIC integration (2005)

A standard non-metallized liquid crystal polymer (LCP) 4 mil thick microwave substrate with depth-controlled laser-micromachined cavities was investigated as a system-level packaging layer for integrated packaging of monolithic microwave integrated circuits (MMICs) and radio frequency microelectromechanical systems (RF MEMS) switches. The RF characteristics of air/dielectric discontinuities at the cavity interfaces were first simulated and the results show that LCP's low dielectric constant enables cavity dimensions to be arbitrarily chosen without significantly affecting the RF performance. To test this packaging concept a 4 mil LCP sheet with twelve 1 mm /spl times/ 2.4 mm /spl times/ 2 mil deep cavities was fabricated. Air-bridge type RF MEMS switches were fabricated on a base LCP substrate and measured before and after introducing the laser-micromachined superstrate layer. The measurements show almost no difference in packaged and unpackaged form for frequencies up to 40 GHz. The concept of a system-level package on a flexible, low-cost, organic substrate has been demonstrated for the first time. The same technique could be used for integrating MMICs all in a near-hermetic low-cost LCP module.
Accurate mobile robot dead-reckoning with a precision-calibrated fiber-optic gyroscope (2001)

This paper describes two methods aimed at improving dead-reckoning accuracy with fiber-optic gyroscopes (FOGs) in mobile robots. The first method is a precision calibration procedure for FOGs, which effectively reduces the ill effects of nonlinearity of the scale-factor and temperature dependency. The second method is the implementation of an indirect feedback Kalman filter that fuses the sensor data from the FOG with the odometry system of the mobile robot. The paper also provides experimental results and compares the relative effectiveness of the two methods as implemented on a four-wheel drive/skidsteer Pioneer AT mobile robot.
Dynamic covalent chemistry on self-templating PNA oligomers: formation of a bimolecular PNA quadruplex (2005)

The tetramolecular PNA quadruplex motif has been probed using a dynamic covalent chemistry (DCC) approach to create and characterize a bimolecular PNA quadruplex.