gebhart/patrepeval huggingface dataset:
TI anisotropic model building using borehole sonic logs acquired in heterogeneous formations (2013)

Inverting borehole sonic data for anisotropic elastic parameters requires data acquired in, at least, two different orientations. In practice this often means combining acquisitions from two offset wells, which is only straightforward if the encountered formations are laterally continuous. If wells do not tie laterally, or if data acquired at different depths in vertically heterogeneous strata need to be combined, then an inversion strategy is required that explicitly takes heterogeneity into account. This short note outlines such a strategy on the basis of borehole sonic and conventional petrophysical data, structural information, and well surveys. A new and sophisticated workflow was developed to estimate TI anisotropic parameters from borehole sonic logs, adopting a smart data clustering approach. Among other things, the output consists of elastic properties as a function of independently acquired data such as gamma ray and density. In turn, these expressions constitute a model that is driven by measurements instead of assumptions, that can be established also in the presence of lateral and vertical heterogeneity, and that can be applied in neighboring wells where the amount of sonic data are insufficient for a complete inversion.
Toward Improved Catholyte Materials for Redox Flow Batteries: What Controls Chemical Stability of Persistent Radical Cations? (2017)

Catholyte materials are used to store positive charge in energized fluids circulating through redox flow batteries (RFBs) for electric grid and vehicle applications. Energy-rich radical cations (RCs) are being considered for use as catholyte materials, but to be practically relevant, these RCs (that are typically unstable, reactive species) need to have long lifetimes in liquid electrolytes under the ambient conditions. Only few families of such energetic RCs possess stabilities that are suitable for their use in RFBs; currently, the derivatives of 1,4-dialkoxybenzene look the most promising. In this study, we examine factors that define the chemical and electrochemical stabilities for RCs in this family. To this end, we used rigid bis-annulated molecules that by design avoid the two main degradation pathways for such RCs, viz., their deprotonation and radical addition. The decay of the resulting RCs are due to the single remaining reaction: O-dealkylation. We establish the mechanism for this reaction and examine factors controlling its rate. In particular, we demonstrate that this reaction is initiated by the nucleophile attack of the counteranion on the RC partner. The reaction proceeds through the formation of the aroxyl radicals whose secondary reactions yield the corresponding quinones. The O-dealkylation accelerates considerably when the corresponding quinone has poor solubility in the electrolyte, and the rate depends strongly on the solvent polarity. Our mechanistic insights suggest new ways of improving the RC catholytes through molecular engineering and electrolyte optimization.
Directed assembly of high density single-walled carbon nanotube patterns on flexible polymer substrates (2009)

We report an effective technique for the controlled assembly of single-walled carbon nanotubes (SWNTs) and demonstrate organized high density network architectures on soft polymeric substrates. We utilize the surface energy differential between a plasma treated (hydrophilic) parylene-C surface and a photoresist (hydrophobic) surface to create microscale patterns of SWNT networks on a 10 microm thick parylene-C substrate. The large scale fabrication of patterned SWNT structures presented is achieved by performing site-selective fluidic assembly of SWNTs. Electrically continuous nanotube network micro-arrays as small as 4 microm wide that are up to 1500 microm long with controlled separation have been fabricated by dissolving the photoresist after assembly. Electrical and mechanical characterization of nanotube networks on the flexible substrate in both static and dynamic modes indicates that the structure can handle both compressive and tensile deformations with no hysteresis. The technology presented has immediate applications in making thin film transistors, interconnects and sensors on flexible substrates.
Near‐Stoichiometric Silicon Carbide from an Economical Polysilane Precursor (1992)

Na condensation of CH 3 SiHCl 2 gives polysilanes of the type ((CH 3 SiH) x (CH 3 Si) y ) n (where x + y = 1) whose pyrolysis in a stream of Ar gives SiC and a substantial amount of elemental Si. Treatment of such polysilanes with catalytic quantities of group‐IV‐metal–organometallic complexes, ((η‐C 5 H 5 ) 2 ZrH 2 ) n , (η‐C 5 H 5 ) 2 Zr(CH 3 ) 2 , (η‐C 5 H 5 ) 2 ZrHCl, and (η‐C 5 H 5 ) 2 ‐Ti(CH 3 ) 2 , results in cross‐linking processes such that pyrolysis of these polysilanes gives close to stoichiometric SiC (≥95 wt %) and only very little elemental Si.
Unified perception-prediction model for context aware text recognition on a heterogeneous many-core platform (2011)

Existing optical character recognition (OCR) software tools can perform text image detection and pattern recognition with fairly high accuracy, however their performance will be significantly impaired when the image of the character is partially blocked or smudged. Such missing information does not hinder the human perception because we predict the missing part based on the word level and sentence level context of the character. In order to mimic the human cognitive behavior, we developed a hybrid cognitive architecture combining two neuromorphic computing models, i.e. brain-state-in-a-box (BSB) and cogent confabulation, to achieve context-aware text recognition. The BSB model performs the character recognition from input image while the confabulation models perform the context-aware prediction based on the word and sentence knowledge bases. The software tool is implemented on an 1824-core computing cluster. Its accuracy and performance are analyzed in the paper.
T-splines and T-NURCCs (2003)

This paper presents a generalization of non-uniform B-spline surfaces called T-splines. T-spline control grids permit T-junctions, so lines of control points need not traverse the entire control grid. T-splines support many valuable operations within a consistent framework, such as local refinement, and the merging of several B-spline surfaces that have different knot vectors into a single gap-free model. The paper focuses on T-splines of degree three, which are C2 (in the absence of multiple knots). T-NURCCs (Non-Uniform Rational Catmull-Clark Surfaces with T-junctions) are a superset of both T-splines and Catmull-Clark surfaces. Thus, a modeling program for T-NURCCs can handle any NURBS or Catmull-Clark model as special cases. T-NURCCs enable true local refinement of a Catmull-Clark-type control grid: individual control points can be inserted only where they are needed to provide additional control, or to create a smoother tessellation, and such insertions do not alter the limit surface. T-NURCCs use stationary refinement rules and are C2 except at extraordinary points and features.
Towards a Unified Framework for Pose, Expression, and Occlusion Tolerant Automatic Facial Alignment (2015)

We propose a facial alignment algorithm that is able to jointly deal with the presence of facial pose variation, partial occlusion of the face, and varying illumination and expressions. Our approach proceeds from sparse to dense landmarking steps using a set of specific models trained to best account for the shape and texture variation manifested by facial landmarks and facial shapes across pose and various expressions. We also propose the use of a novel l1-regularized least squares approach that we incorporate into our shape model, which is an improvement over the shape model used by several prior Active Shape Model (ASM) based facial landmark localization algorithms. Our approach is compared against several state-of-the-art methods on many challenging test datasets and exhibits a higher fitting accuracy on all of them.
P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity (1997)

The MDR1 P-glycoprotein (Pgp), a member of the ATP-binding cassette family of transporters, is a transmembrane ATPase efflux pump for various lipophilic compounds, including many anti-cancer drugs. mAb UIC2, reactive with the extracellular moiety of Pgp, inhibits Pgp-mediated efflux. UIC2 reactivity with Pgp was increased by the addition of several Pgp-transported compounds or ATP-depleting agents, and by mutational inactivation of both nucleotide-binding domains (NBDs) of Pgp. UIC2 binding to Pgp mutated in both NBDs was unaffected in the presence of Pgp transport substrates or in ATP-depleted cells, whereas the reactivities of the wild-type Pgp and Pgps mutated in a single NBD were increased by these treatments to the level of the double mutant. These results indicate the existence of different Pgp conformations associated with different stages of transport-associated ATP hydrolysis and suggest trapping in a transient conformation as a mechanism for antibody-mediated inhibition of Pgp.
Study of the effect of layer thickness, beam energy, and metal density on the resistless silicide direct-write electron-beam lithography process for the fabrication of nanostructures (2000)

To overcome the limitation of resists in electron beam lithography, a resistless electron beam lithography technique was recently developed. In the silicide direct-write electron-beam lithography process (SiDWEL), a thin metallic film is deposited on a silicon surface. A low-energy (&lt;3 keV) electron beam is then used to enable the intermixing of the metal and the silicon layers through thermal effects. A chemical etch is then used to remove the unexposed metal regions. Thermal calculations are performed using a Monte Carlo simulation of electron trajectories and are correlated with experiments using Ni as the thin metallic film. A comparison of the doses required for the formation of several metals is also done. Results show that the SiDWEL process is possible when the electrons lose all their energy in a layer thickness comparable to the phonon mean free path. Finally, experiments are performed using multilayer samples to form silicide structures.
A measurement method for determining the direction of propagation of flicker and for tracing a flicker source (2005)

This paper describes a new and highly efficient measurement method (algorithm) that determines how flicker propagates throughout the network and also traces the dominant flicker source. The fundam ...
Context-aware Synthesis for Video Frame Interpolation (2018)

Video frame interpolation algorithms typically estimate optical flow or its variations and then use it to guide the synthesis of an intermediate frame between two consecutive original frames. To handle challenges like occlusion, bidirectional flow between the two input frames is often estimated and used to warp and blend the input frames. However, how to effectively blend the two warped frames still remains a challenging problem. This paper presents a context-aware synthesis approach that warps not only the input frames but also their pixel-wise contextual information and uses them to interpolate a high-quality intermediate frame. Specifically, we first use a pre-trained neural network to extract per-pixel contextual information for input frames. We then employ a state-of-the-art optical flow algorithm to estimate bidirectional flow between them and pre-warp both input frames and their context maps. Finally, unlike common approaches that blend the pre-warped frames, our method feeds them and their context maps to a video frame synthesis neural network to produce the interpolated frame in a context-aware fashion. Our neural network is fully convolutional and is trained end to end. Our experiments show that our method can handle challenging scenarios such as occlusion and large motion and outperforms representative state-of-the-art approaches.
Preparing thermoplastic aromatic polyimides (1973)

Method prepares aromatic polyimides with significantly reduced glass-transition temperatures and without accompanying loss of high-level thermo-oxidative stability which has been typical. This has been made possible by use of diamine monomers with specific stereoisomeric features.
Abstract 448: Expression of Galectins in high grade serous ovarian cancer (2016)

Abstract Ovarian cancer (OC) is the 5th leading cause of cancer-related deaths in the Western world. Despite improvements in various treatments, the five-year survival of patients with advanced stage disease remains less than 40%. Approximately 70% of malignant OCs are attributed to the high-grade serous carcinoma (HGSC) histological subtype, which is typically treated by a surgical tumor debulking followed by platinum/taxane chemotherapy. Unfortunately, although approximately 80% of patients respond well to the initial chemotherapy treatment, a large portion of patients develop drug resistance during subsequent cycles of chemotherapy. The non-uniformity of response to therapy complicates the clinical decision-making process and reflects the genetic complexity that gives rise to intra-tumor heterogeneity. Clearly, there is an urgent need to develop reliable clinical biomarkers to identify patients at different levels of risk for specific outcomes. Here, we have investigated the expression of galectins (gal) in HGSC and examined their potential as biomarkers. Galectins have been shown to play a dual role in cancer progression. When released in the extracellular space by cancer cells, they are particularly efficient in creating an immunosuppressive tumor microenvironment, both locally and systemically. Inside cancer cells, they provide cancer cells with increased resistance to apoptosis induced by chemotherapeutic agents. Using tissue microarrays constructed from formalin fixed paraffin embedded tissues from 209 patients with HGSC, we have identified a new protein signature that takes into account the expression of galectins in both cancer and stromal cells. Our study showed that increased protein expression of stromal gal-1 and epithelial gal-8/9 in primary tumors was associated with a poor response to treatment in patients with HGSC. This signature also increased the predictive value of CA-125 on five-year disease-free survival, chemotherapy treatment response and five-year overall survival. Univariate and multivariate analyses revealed that gal-8 and gal-9 were both independent predictors of chemoresistance and overall survival, respectively. From a fundamental point of view, our project also contributes to better define the heterogeneity of the disease. Overall, these data provide a rational for further studies of Galectins in OC. Citation Format: Marilyne Labrie, Laudine Communal, Maria-Claudia Vladoiu, Pascal Dupont, Anne-Marie Mes-Masson, Yves St-Pierre. Expression of Galectins in high grade serous ovarian cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 448.
Synthetic Sex Pheromone Components Disrupt Orientation, but not Mating, in the Fall Cankerworm, Alsophila pometaria (Lepidoptera: Geometridae) (1986)

Small-plot field experiments were done to determine whether synthetic sex pheromone components of the fall cankerworm, Alsophila pometaria (Harris), released individually or as a ternary blend from several point sources, could 1) disrupt orientation of male moths to pheromone-baited traps and 2) reduce incidence of mating in females. Three experiments were carried out using red rubber septa and Hercon laminate chips as releasers. In the first two the releasers were arranged at several points around one or two elm trees in each experimental plot; in the third experiment the releasers were directly attached to tree trunks. In all experiments the ternary blend, as well as the two tetraene components, (Z,Z,Z,E)-3,6,9,11-nonadecatetraene and (Z,Z,Z,Z)-3,6,9,11-nonadecatetraene, when deployed singly, showed excellent disruption of orientation of males to pheromone-baited traps but none of these treatments reduced incidence of mating in females collected from trees in experimental plots. (Z,Z,Z)-3,6,9-nonadecatriene, the third pheromone component, was not effective in disrupting either male orientation or mating. Behavioral observations indicated that in untreated plots males tended to orient to trees initially and then searched for females on the tree trunk and on the ground close to the trunk. The identical behavior exhibited by males in pheromone-permeated plots may have contributed to our inability to demonstrate mating disruption through application of pheromones. A high male/female ratio also appeared to contribute to lack of mating reduction.
Myelin-associated glycoprotein, MAG, selectively binds several neuronal proteins (1999)

Myelin-associated glycoprotein (MAG) is a potent inhibitor of axonal regeneration and also, depending on the age and type of neuron, can promote axonal growth. In addition, MAG influences stability of both myelin and the axon in the intact, mature nervous system. The identity of the neuron/axonal MAG-binding receptor responsible for effecting these responses is not known. Here we show that a soluble, chimeric form of MAG, MAG-Fc, can bind to the neuronal cell body and neurites equally well, in a sialic acid-dependent manner. Importantly, MAG-Fc specifically precipitates a number of surface proteins from post-natal cerebellar, dorsal root ganglion (DRG) and PC12 neurons. These proteins are not precipitated by a control Fc-containing chimera and are not apparent when a MAG antibody is included in the precipitation mix as a competitive inhibitor. Based on molecular weight, two prominent proteins of 190 and 250 kD are precipitated from all three neuron types. The 190 kD protein is a sialoglycoprotein, since it is not apparent in the precipitate from neurons which have been desialylated. Other proteins are precipitated but are less abundant and are different for each type of neuron. One or more of these proteins is/are likely to be the functional MAG receptor.
Solution Processed Organic Solar Cells with High Open Circuit Voltages Approaching 1.3 V (2007)

Organic photovoltaics based on solution processing is currently receiving tremendous attention because of recent progress made in improved conversion efficiencies, and the potential for use in large area flexible solar cells. Efficient dissociation of the photogenerated excitons is facilitated in these systems by introducing hetero-junctions between a polymer, which acts as the electron donor, and another polymer and/or small molecule as the electron acceptor. Currently most approaches are focusing on the use of C60 and derivatives thereof as electron acceptors together with regio-regular poly(3-hexylthiophene) (P3HT) as electron donor. While these devices show high quantum efficiencies, the obtained open circuit voltage near 0.7 V is rather low.
Accurate Deep Direct Geo-Localization from Ground Imagery and Phone-Grade GPS (2018)

One of the most critical topics in autonomous driving or ride-sharing technology is to accurately localize vehicles in the world frame. In addition to common multiview camera systems, it usually also relies on industrial grade sensors, such as LiDAR, differential GPS, high precision IMU, and etc. In this paper, we develop an approach to provide an effective solution to this problem. We propose a method to train a geo-spatial deep neural network (CNN+LSTM) to predict accurate geo-locations (latitude and longitude) using only ordinary ground imagery and low accuracy phone-grade GPS. We evaluate our approach on the open dataset released during ACM Multimedia 2017 Grand Challenge. Having ground truth locations for training, we are able to reach nearly lane-level accuracy. We also evaluate the proposed method on our own collected images in San Francisco area often described as downtown canyon where consumer GPS signals are extremely inaccurate. The results show the model can predict quality locations that suffice in real business applications, such as ride-sharing, only using phone-grade GPS. Unlike classic visual localization or recent PoseNet-like methods that may work well in indoor environments or small-scale outdoor environments, we avoid using a map or an SFM (structure-from-motion) model at all. More importantly, the proposed method can be scaled up without concerns over the potential failure of 3D reconstruction.
ExoSensor 517: A Dual-Analyte Fluorescent Chemosensor for Visualizing Neurotransmitter Exocytosis (2013)

A dual-analyte fluorescent chemosensor (ExoSensor 517) for the direct visualization of neurotransmitters released upon exocytosis is presented. The sensor exploits the high concentration of neurotransmitters (e.g., glutamate, norepinephrine, and dopamine) and the pH gradient between the vesicle and synaptic cleft. The cooperative recognition elements require both binding and a change in environmental pH to afford a fluorescence response which makes ExoSensor 517 one of the first integrated molecular logic gates to be used for biological applications.
Second Generation Assay for Thyrotropin Receptor Antibodies Has Superior Diagnostic Sensitivity for Graves’ Disease (1999)

Detection of autoantibodies to the TSH receptor (TSH-R) in Graves' disease has found widespread use in clinical routine and is performed mostly by commercial RRAs measuring TSH binding inhibitory activity. We report in this study on a second generation TSH binding inhibitory assay using the human recombinant TSH-R with two major improvements: 1) superior diagnostic sensitivity for Graves' disease, and 2) for the first time, nonradioactive and radioactive coated tube (CT) technology. Full-length human recombinant TSH-R was expressed in the K562 leukemia cell line and grown in suspension at a high density. A murine monoclonal antibody was selected for binding to the native TSH-R without interfering with autoantibodies or TSH and was coated to polystyrene tubes. After detergent extraction, TSH-R was affinity immobilized on antibody-coated tubes. The binding of TSH to the TSH-R could be demonstrated by the addition of 125I- or acridinium ester-labeled bovine TSH, and this binding could be inhibited by sera from patients with Graves' disease up to 95%. Subsequently, these novel assays, a CT RRA and a CT luminescence receptor assay, were compared to the conventional RRA based on porcine antigen in a blinded clinical multicenter trial. Sera from 328 patients with Graves' disease (86 untreated, 116 treated, and 126 in remission) and 520 controls (comprised of healthy blood donors and patients with autoimmune diseases or goiter) were tested in all 3 assays. Receiver-operating characteristic plot analysis resulted in a specificity of 99.6% with a sensitivity of 98.8% for both CT assays, compared to 99.6% specificity and 80.2% sensitivity for the conventional RRA (P < 0.001). In all 3 groups of patients with Graves' disease, the 2 CT assays were significantly more sensitive for the disease than the conventional assay, without loss of specificity in the control groups. This increase in sensitivity and the nonradioactive or radioactive CT format constitute a significant improvement over the currently available assays.