gebhart/patrepeval huggingface dataset:
Pierre Royer (1996)

Obituaries| December 09 2008 Pierre Royer Subject Area: Endocrinology , Women's and Children's Health Raphaël R. Rappaport Raphaël R. Rappaport Hôpital des Enfants Malades, Paris Search for other works by this author on: This Site PubMed Google Scholar Hormone Research (1996) 45 (6): 259–260. https://doi.org/10.1159/000184800 Article history Published Online: December 09 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Raphaël R. Rappaport; Pierre Royer. Hormone Research 1 June 1996; 45 (6): 259–260. https://doi.org/10.1159/000184800 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsHormone Research in Paediatrics Search Advanced Search This content is only available via PDF. 1996Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
A 4-/spl mu/a quiescent-current dual-mode digitally controlled buck converter IC for cellular phone applications (2004)

This paper describes a dual-mode digitally controlled buck converter IC for cellular phone applications. An architecture employing internal power management is introduced to ensure voltage compatibility between a single-cell lithium-ion battery voltage and a low-voltage integrated circuit technology. Special purpose analog and digital interface elements are developed. These include a ring-oscillator-based A/D converter (ring-ADC), which is nearly entirely synthesizable, is robust against switching noise, and has flexible resolution control, and a very low power ring-oscillator-multiplexer-based digital pulse-width modulation (PWM) generation module (ring-MUX DPWM). The chip, which includes an output power stage rated for 400 mA, occupies an active area 2 mm/sup 2/ in 0.25-/spl mu/m CMOS. Very high efficiencies are achieved over a load range of 0.1-400 mA. Measured quiescent current in PFM mode is 4 /spl mu/A.
The potassium titanyl phosphate structure field: a model for new nonlinear optical materials (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe potassium titanyl phosphate structure field: a model for new nonlinear optical materialsGalen D. Stucky, Mark L. F. Phillips, and Thurman E. GierCite this: Chem. Mater. 1989, 1, 5, 492–509Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/cm00005a008https://doi.org/10.1021/cm00005a008research-articleACS PublicationsRequest reuse permissionsArticle Views606Altmetric-Citations220LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Slurry Injector for the Amelioration of Subsoils (1986)

A practical method is presented by which lime [CaEO3] or gypsum [CaSO4] can be injected evenly into acid or unstable subsoils to raise subsoil pH in the former and to stabilize sodic subsoils by replacing sodium with calcium in the latter. Effective amelioration of these soils would substantially raise the production of some 10 x 10{6} ha of the Australian wheat belt. The implement is a 2,500 l tank with a rear mounted 4 tine deep ripper. Slurries are pumped from the tank and delivered to the trailing edge of each tine. The unit is powered by a 120 k W front wheel assist tractor. Rates of lime or gypsum from 0.5 t o 60 t ha{-1} can be applied. This implement has been used to establish four field sites prior to the 1986 sowing season to evaluate soil chemical and physical changes and its effect on crop growth.
Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B (2014)

As a gram-positive, spore-forming anaerobic bacillus, Clostridium difficile (C. difficile) is responsible for severe and fatal pseudomembranous colitis, and poses the most urgent antibiotic resistance threat worldwide. Epidemic C. difficile is the leading cause of antibiotic-associated diarrhoea globally, especially diarrhoea due to the emergence of hypervirulent strains associated with high mortality and morbidity. TcdB, one of the key virulence factors secreted by this bacterium, enters host cells through a poorly understood mechanism to elicit its pathogenic effect. Here we report the first identification of the TcdB cellular receptor, chondroitin sulfate proteoglycan 4 (CSPG4). CSPG4 was initially isolated from a whole-genome human shRNAmir library screening, and its role was confirmed by both TALEN- and CRISPR/Cas9-mediated gene knockout in human cells. CSPG4 is critical for TcdB binding to the cell surface, inducing cytoskeleton disruption and cell death. A direct interaction between the N-terminus of CSPG4 and the C-terminus of TcdB was confirmed, and the soluble peptide of the toxin-binding domain of CSPG4 could protect cells from the action of TcdB. Notably, the complete loss of CSPG4/NG2 decreased TcdB-triggered interleukin-8 induction in mice without significantly affecting animal mortality. Based on both the in vitro and in vivo studies, we propose a dual-receptor model for TcdB endocytosis. The discovery of the first TcdB receptor reveals a previously unsuspected role for CSPG4 and provides a new therapeutic target for the treatment of C. difficile infection.
Identification of Topological Entities and Naming Mapping for Parametric CAD Model Exchanges (2005)

As collaborative design and configuration design gain increasing importance in product development, it becomes essential to exchange parametric CAD models among participants. Parametric CAD models can be represented and exchanged in the form of a macro file or a part file that contains the modeling history of a product. The modeling history of a parametric CAD model contains feature specifications and each feature has selection information that records the name of the referenced topological entities. Translating this selection information requires solving the problems of how to identify the referenced topological entities of a feature (persistent naming problem) and how to convert the selection information into the format of the receiving CAD system (naming mapping problem). The present paper introduces the problem of exchanging parametric CAD models and proposes a solution to naming mapping.
Impact ionization rates in (100) A1 <sub>0.48</sub> In <sub>0.52</sub> As (1990)

Impact ionization rates for electrons and holes in (100) A1 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.48</sub> In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.52</sub> As were determined from photo multiplication measurements using AIInAs / FaInAs <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p +-i-n</sup> diodes grown by metal-organic vapor phase epitaxy (MOVPE). The impact ionization rate ratio (prop; / beta;) was derived as being 2.0 ~ 3.5 over the electric field range from 400 to 650 KV / cm. Ionization rates were found to be smaller than those previously reported.
Field Experiments and the Study of Voter Turnout (2012)

Although field experiments have long been used to study voter turnout, only recently has this research method generated widespread scholarly interest. This article reviews the substantive contributions of the field experimental literature on voter turnout. This literature may be divided into two strands, one that focuses on the question of which campaign tactics do or do not increase turnout and another that uses voter mobilization campaigns to test social psychological theories. Both strands have generated stubborn facts with which theories of cognition, persuasion and motivation must contend.
Characterization of a side-type ferrite inductively coupled plasma source for large-scale processing (2008)

A new type of inductively coupled plasma (ICP) utilizing an array of auxiliary discharges enhanced with ferromagnetic cores and placed at the chamber side is developed and characterized over a wide range of discharge conditions. The ICP electrical and plasma characteristics are measured over a wide range of discharge powers and argon gas pressures. It is shown that at 400 kHz driving frequency the antenna power factor of this ICP is close to 1, so the antenna voltage and current are much lower than those in a conventional ICP at similar rf power. Due to low driving frequency and low antenna voltage, the capacitive coupling in the ICP mode is practically eliminated, while due to enhanced ferromagnetic core coupling, the power transfer efficiency is higher than 95% at an rf power larger than 0.5 kW. Langmuir probe measurements show that the radial plasma non-uniformity over 300 mm can be less than 3%. This plasma source is expected to be suitable for large-scale plasma processing.
A Substance P Antagonist Reduces Axonal Injury and Improves Neurologic Outcome When Administered Up to 12 Hours after Traumatic Brain Injury (2010)

Previous studies have demonstrated that the compound N-acetyl-L-tryptophan (NAT) reduces brain edema and improves functional outcome following traumatic brain injury (TBI). In this study we examined whether this effect was mediated via the neurokinin-1 receptor, and whether there was an effect on axonal injury. We also explored whether the compound was effective, even when administered at delayed time points. Male Sprague-Dawley rats were subject to acceleration-induced, diffuse TBI and administered NAT, its inactive D-enantiomer, or saline vehicle. In contrast to NAT (2.5 mg/kg), the inactive D-enantiomer was ineffective at improving rotarod motor performance after TBI. NAT also improved cognitive outcome as assessed by the Morris water maze and novel object recognition tests, and reduced axonal injury at 5 and 24 h after TBI as assessed by amyloid precursor protein immunohistochemistry. However, efficacy of the membrane-impermeable NAT was limited to administration within 5 h, whereas administration of a form of NAT, L-732,138 (47 mg/kg), in which a trifluoromethyl benzyl ester group has been added, making it highly lipid soluble and able to cross the intact blood-brain barrier, significantly improved motor outcome, even when administration was delayed by as much as 12 h. We conclude that the neuroprotective effects of NAT are receptor-mediated, and that administration of the membrane-permeable form of the compound can be effective even up to 12 h after TBI.
Erratum: Improved three-dimensional image correlation for surface displacement measurement [Optical Engineering <italic>35</italic>(7), 1911–2004 (1996)] (1997)

This PDF contains the Communications and Errata for Optical Engineering Volume 36, Issue 8.
A Dual-Mode Surface Display System for the Maturation and Production of Monoclonal Antibodies in Glyco-Engineered Pichia pastoris (2013)

State-of-the-art monoclonal antibody (mAb) discovery methods that utilize surface display techniques in prokaryotic and eukaryotic cells require multiple steps of reformatting and switching of hosts to transition from display to expression. This results in a separation between antibody affinity maturation and full-length mAb production platforms. Here, we report for the first time, a method in Glyco-engineered Pichiapastoris that enables simultaneous surface display and secretion of full-length mAb molecules with human-like N-glycans using the same yeast cell. This paradigm takes advantage of homo-dimerization of the Fc portion of an IgG molecule to a surface-anchored "bait" Fc, which results in targeting functional "half" IgGs to the cell wall of Pichiapastoris without interfering with the secretion of full length mAb. We show the utility of this method in isolating high affinity, well-expressed anti-PCSK9 leads from a designed library that was created by mating yeasts containing either light chain or heavy chain IgG libraries. Coupled with Glyco-engineered Pichiapastoris, this method provides a powerful tool for the discovery and production of therapeutic human mAbs in the same host thus improving drug developability and potentially shortening the discovery time cycle.
Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i> (2003)

Both dauer formation (a stage of developmental arrest) and adult life-span in Caenorhabditis elegans are negatively regulated by insulin-like signaling, but little is known about cellular pathways that mediate these processes. Autophagy, through the sequestration and delivery of cargo to the lysosomes, is the major route for degrading long-lived proteins and cytoplasmic organelles in eukaryotic cells. Using nematodes with a loss-of-function mutation in the insulin-like signaling pathway, we show that bec-1, the C. elegans ortholog of the yeast and mammalian autophagy gene APG6/VPS30/beclin1, is essential for normal dauer morphogenesis and life-span extension. Dauer formation is associated with increased autophagy and also requires C. elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans.
Arbitrary power division branch-line hybridterminated by arbitrary impedances (1999)

If a four-port network is terminated by arbitrary impedances, conventional methods for even- and/or odd- mode excitation analyses cannot be used because no symmetry planes exist. Under these conditions, new design equations for an asymmetric branch-line hybrid with arbitrary power division are introduced. A uniplanar branch-line hybrid terminated by 45, 35, 60 and 50 Ω with a power splitting ratio of 3 dB was fabricated and measured.
Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. (1991)

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a new antiviral compound with activity against herpes simplex virus (HSV) and retroviruses including human immunodeficiency virus. Although it has been suggested that the anti-HSV action of PMEA is through inhibition of the viral DNA polymerase via the diphosphorylated metabolite of PMEA (PMEApp), no conclusive evidence for this has been presented. We report that in cross-resistance studies, a PMEA-resistant HSV variant (PMEAr-1) was resistant to phosphonoformic acid, a compound which directly inhibits the HSV DNA polymerase. In addition, phosphonoformic acid-resistant HSV variants with defined drug resistance mutations within the HSV DNA polymerase gene were resistant to PMEA. Furthermore, the HSV DNA polymerase purified from PMEAr-1 was resistant to PMEApp in comparison with the enzyme from the parental virus. Moreover, PMEA inhibited HSV DNA synthesis in cell culture. These results provide strong evidence that HSV DNA polymerase is the major target for the anti-viral action of PMEA. Further studies showed that HSV DNA polymerase incorporated PMEApp into DNA in vitro, while the HSV polymerase-associated 3'-5' exonuclease was able to remove the incorporated PMEA. Thus, the inhibition of HSV DNA polymerase by PMEApp appears to involve chain termination after its incorporation into DNA.
First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013 (2014)

Binary file ES_Abstracts_Final_ECDC.txt matches
Counting Triangles in Large Graphs using Randomized Matrix Trace Estimation (2010)

Triangle counting is an important problem in graph mining with several real-world applications. Interesting metrics, such as the clustering coefficient and the transitivity ratio, involve computing the number of triangles. Furthermore, several interesting graph mining applications rely on computing the number of triangles in a large-scale graph. However, exact triangle counting is expensive and memory consuming, and current approximation algorithms are unsatisfactory and not practical for very large-scale graphs. In this paper we present a new highly-parallel randomized algorithm for approximating the number of triangles in an undirected graph. Our algorithm uses a well-known relation between the number of triangles and the trace of the cubed adjacency matrix. A Monte-Carlo simulation is used to estimate this quantity. Each sample requires O(|E|) time and O(ǫ 2 log(1/δ)ρ(G) 2 ) samples are required to guarantee an (ǫ, δ)-approximation, where ρ(G) is a measure of the triangle sparsity of G (ρ(G) is not necessarily small). Our algorithm requires only O(|V |) space in order to work efficiently. We present experiments that demonstrate that in practice usually only O(log 2 |V |) samples are required to get good approximations for graphs frequently encountered in data-mining tasks, and that our algorithm is competitive with state-of-the-art approximate triangle counting methods both in terms of accuracy and in terms of running-time. The use of Monte-Carlo simulation support parallelization well: our algorithm is embarrassingly parallel with a critical path of only O(|E|), achievable on as few as O(log 2 |V |) processors.
A Versatile, Ultralight, Nitrogen‐Doped Graphene Framework (2012)

Graphene lite: a density of (2.1 ± 0.3) mg cm(-3), the lowest to date for a graphene framework architecture, is achieved by preparing an ultralight, N-doped, 3D graphene framework (see photo of a block of the material balancing on a dandelion). Its adsorption capacity for oils and organic solvents is much higher than that of the best carbonaceous sorbents, and it is a promising electrode material for supercapacitors (484 F g(-1)) and as a metal-free catalyst for the oxygen reduction reaction.
Repeatability of Automated FIB Prepared TEM Samples with Low keV Cleaning (2010)

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.
Evolution of the Isoprene Biosynthetic Pathway in Kudzu  (2005)

Isoprene synthase converts dimethylallyl diphosphate, derived from the methylerythritol 4-phosphate (MEP) pathway, to isoprene. Isoprene is made by some plants in substantial amounts, which affects atmospheric chemistry, while other plants make no isoprene. As part of our long-term study of isoprene synthesis, the genetics of the isoprene biosynthetic pathway of the isoprene emitter, kudzu (Pueraria montana), was compared with similar genes in Arabidopsis (Arabidopsis thaliana), which does not make isoprene. The MEP pathway genes in kudzu were similar to the corresponding Arabidopsis genes. Isoprene synthase genes of kudzu and aspen (Populus tremuloides) were cloned to compare their divergence with the divergence seen in MEP pathway genes. Phylogenetic analysis of the terpene synthase gene family indicated that isoprene synthases are either within the monoterpene synthase clade or sister to it. In Arabidopsis, the gene most similar to isoprene synthase is a myrcene/ocimene (acyclic monoterpenes) synthase. Two phenylalanine residues found exclusively in isoprene synthases make the active site smaller than other terpene synthase enzymes, possibly conferring specificity for the five-carbon substrate rather than precursors of the larger isoprenoids. Expression of the kudzu isoprene synthase gene in Arabidopsis caused Arabidopsis to emit isoprene, indicating that whether or not a plant emits isoprene depends on whether or not it has a terpene synthase capable of using dimethylallyl diphosphate.
Orienting Zeolite L Microcrystals with a Functional Linker (2010)

A glowing endorsement: Arranging zeolite L crystals into luminescent macroscopic structures allows preparation of dense, homogeneous, well-oriented, stable, and highly organized functional monolayers (see picture). The color of the luminescence of the resulting layers can be fine-tuned by changing the type and number of lanthanide ions coordinated to the linker, the guest inside the channels of the zeolite host, and the excitation wavelength.
An <i>in vivo</i> method for the evaluation of catheter thrombogenicity (1987)

A new method has been developed to evaluate the relative thrombogenicity of vascular catheters. The technique provides a means to quantitatively differentiate between catheters made from different polymeric materials. Autologous In-111 labeled platelets were infused into a dog model and catheters were then inserted into the external jugular vein of the dog. The neck region was scanned using gamma camera imaging. Comparisons between catheter materials were made using computer generated uptake slopes during the first 40 min of the scan. In addition to scintigraphy, visual assessment of thrombus deposition, thrombus weight, platelet deposition, and scanning electron microscopy were used to validate the technique. Poly(vinyl chloride), polyurethane, heparinized polyurethane, and silicone catheter materials were tested. It was found that heparinized polyurethane was the least thrombogenic of all materials evaluated.