gebhart/patrepeval huggingface dataset:
Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation (2002)

Regulation of liver cell proliferation is a key event to control organ size during development and liver regeneration. Methionine adenosyltransferase (MAT) 2A is expressed in proliferating liver, whereas MAT1A is the form expressed in adult quiescent hepatocytes. Here we show that, in H35 hepatoma cells, growth factors such as hepatocyte growth factor (HGF) and insulin up-regulated MAT2A expression. HGF actions were time- and dose-response dependent and required transcriptional activity. Mitogen-activated protein (MAP) kinase and phosphatidylinositol 3-phosphate kinase (PI 3-K) pathways were required for both HGF-induced cell proliferation and MAT2A up-regulation. Furthermore, in H35 cells treated with HGF, the inhibition of these pathways was associated with the switch from the expression of fetal liver MAT2A to the adult liver MAT1A isoform. Fetal liver hepatocytes exhibited an identical response pattern. Treatment of H35 hepatoma cells with MAT2A antisense oligonucleotides decreased cell proliferation induced by HGF; this decrease correlated with the decay in MAT2A messenger RNA (mRNA) levels. Finally, growth inhibitors such as transforming growth factor (TGF) beta blocked HGF-induced MAT2A up-regulation while increasing MAT1A mRNA levels in H35 cells. In conclusion, our results show that MAT2A expression not only correlates with liver cell proliferation but is required for this process.
Stirling Air Conditioned Variable Temperature Seat (SVTS) and Comparison with Thermoelectric Air Conditioned Variable Temperature Seat (VTS) (1998)

<div class="htmlview paragraph">The thermoelectric Variable Temperature Seat, (VTS), offers automotive OEMs a new approach to occupant comfort enhancement in both hot and cold weather. The VTS is capable of both cooling and warming the vehicle occupant relatively efficiently and relatively quietly through the use of conditioned air flow through the seat pad structure.</div> <div class="htmlview paragraph">The subject of this paper, the Stirling Variable Temperature Seat, (SVTS), is the latest advancement in seat cooling and heating technology, and significantly improves upon the thermoelectric, (Peltier), VTS in several significant ways.</div>
Allocation of Responsibility After American Motorcycle Association v. Superior Court (1979)

In its landmark case of Li v. Yellow Cab Co., the California Supreme Court judicially adopted the doctrine of comparative negligence in an action involving a plaintiff and a single defendant. The court in Li specifically avoided making any decision concerning the numerous issues which would be involved in a multi-party action: the relationship of multiple defendants with one another, the right of one defendant to join others for the purpose of sharing payment of the judgment, the respective responsibilities of such parties for the judgment (including those insolvent, partially solvent or possessing an immunity), and the procedure for the settlement of cases. In addition to resolving these important substantive issues in the American Motorcycle decision, the court adopted a philosophical ranking of values which will inevitably effect and guide resolution of the numerous problems in the context of comparative negligence which have not yet been litigated.
172 ADMINISTRATION OF GLUTATHIONE OR THIOREDOXIN TO MEDIUM REDUCES INTRACELLULAR REDOX STATUS AND IMPROVES EMBRYONIC DEVELOPMENT TO THE BLASTOCYST STAGE OF PORCINE IVM/IVF OOCYTES (2005)

Successful in vitro production of blastocysts from immature oocytes can be carried out using in vitro oocyte maturation (IVM), fertilization (IVF), and embryo culture (IVC) at a high level of repeatability in the porcine. However, the rates of in vitro development of IVM/IVF oocytes to the blastocyst stage remained around 20%. The environment in vitro is so simple and materially limited that there exist several stressors in vitro that disturb normal embryo development. Oxidative stress, which is caused by excess production of reactive oxygen species, is a major disturbing factor for the development of pre-implantation embryos in vitro . The series of present experiments were conducted using culture conditions with enhanced reducing capacity by the addition of glutathione (GSH) or thioredoxin to the culture medium to monitor developmental competence of porcine embryos and to verify their intracellular redox status. Cumulus-oocyte complexes were obtained from ovaries recovered from prepubertal gilts. Putative zygotes were produced by IVM of oocytes, followed by IVF (designated as Day 0). They were then cultured in modified NCSU-37 media containing GSH or thioredoxin as an antioxidant, or without any antioxidant (control), and blastocyst development rates on Day 6 were monitored. In addition, intracellular GSH content as a reducing parameter and intracellular H2O2 level as an oxidative parameter were measured; the intracellular redox status in the embryo was verified by the ratio of the GSH to the H2O2. Measurements in each group were replicated six times. Percentages of the embryos that developed to the blastocyst stage were significantly increased when 0.5 or 1.0 µM GSH (29.6 ± 2.7% or 30.4 ± 3.5%, and P &lt; 0.05 or 0.01, respectively) or 1.0 mg/mL thioredoxin (30.6 ± 2.4%, P &lt; 0.01) was added to the medium compared to the percentage in the control group (20.1 ± 2.2%). Intracellular redox status in embryos at the 8- to 12-cell stage or blastocysts was drastically reduced in GSH- or thioredoxin-added groups compared to that in the control group ( P &lt; 0.05 to 0.001). Furthermore, GSH or thioredoxin addition to the medium increased total cell numbers (48.3 ± 2.1 to 49.2 ± 2.1) and lowered ratios of apoptotic cells (6.2 ± 0.6% to 7.0 ± 0.7%) in blastocyst compared to those values in the control group ( P &lt; 0.05; cell number = 39.3 ± 2.0, apoptosis rate = 11.1 ± 1.1%) (37 to 53 embryos in each group were used for the TUNEL assay). These results suggest that the administration of GSH or thioredoxin to the culture medium improves in vitro embryonic development after IVM/IVF of oocytes, and that these beneficial effects are associated with maintenance of the intracellular redox status in a reduced state in porcine embryos.
Cardiovascular consequences of cortisol excess (2005)

Cushing's syndrome is a consequence of primary or, more commonly, secondary oversecretion of cortisol. Cardiovascular disease is the major cause of morbidity and mortality in Cushing's syndrome, and excess risk remains even in effectively treated patients. The cardiovascular consequences of cortisol excess are protean and include, inter alia, elevation of blood pressure, truncal obesity, hyperinsulinemia, hyperglycemia, insulin resistance, and dyslipidemia. This review analyses the relationship of cortisol excess, both locally and at tissue level, to these cardiovascular risk factors, and to putative mechanisms for hypertension. Previous studies have examined correlations between cortisol, blood pressure, and other parameters in the general population and in Cushing's syndrome. This review also details changes induced by short-term cortisol administration in normotensive healthy men.
Proposal of Real Time Predictive Maintenance Platform with 3D Printer for Business Vehicles (2016)

This paper proposes a maintenance platform for business vehicles which detects failure sign using IoT data on the move, orders to create repair parts by 3D printers and to deliver them to the destination. Recently, IoT and 3D printer technologies have been progressed and application cases to manufacturing and maintenance have been increased. Especially in air flight industry, various sensing data are collected during flight by IoT technologies and parts are created by 3D printers. And IoT platforms which improve development/operation of IoT applications also have been appeared. However, existing IoT platforms mainly targets to visualize "things" statuses by batch processing of collected sensing data, and 3 factors of real-time, automatic orders of repair parts and parts stock cost are insufficient to accelerate businesses. This paper targets maintenance of business vehicles such as airplane or high-speed bus. We propose a maintenance platform with real-time analysis, automatic orders of repair parts and minimum stock cost of parts. The proposed platform collects data via closed VPN, analyzes stream data and predicts failures in real-time by online machine learning framework Jubatus, coordinates ERP or SCM via in memory DB to order repair parts and also distributes repair parts data to 3D printers to create repair parts near the destination.
Neural Model Predictive Control for Nonlinear Chemical Processes. (1993)

A neural model predictive contrl strategy combining a neural network for plant identification and a nonlinear programming algorithm for solving nonlinear control problems is proposed. A constrainted nonlinear optimization approach using successive quadratic programming combined with a neural identification network is used to generate the optimum control law for complex continuous chemical reactor systems that have inherent nonlinear dynamics. The neural model predictive controller(NMPC) shows good performance and robustness.
Self-Referenced 200 MHz Octave-Spanning Ti:Sapphire Laser with 50 Attosecond Carrier-Envelope Phase Jitter (2005)

Carrier-envelope phase stabilization of a 200MHz octave-spanning Ti:sapphire laser without external broadening is demonstrated. The individual comb lines spaced by 200MHz can conveniently be resolved using commercial wavemeters. The accumulated in-loop carrier-envelope phase error (integrated from 2.5 mHz to 10 MHz) using a broadband analog mixer as phase detector is 0.117 rad, equivalent to 50 attosecond carrier-envelope phase jitter at 800 nm.
Using GMM and SVM-Based Techniques for the Classification of SSH-Encrypted Traffic (2009)

When employing cryptographic tunnels such as the ones provided by Secure Shell (SSH) to protect their privacy on the Internet, users expect two forms of protection. First, they aim at preserving the privacy of their data. Second, they expect that their behavior, e.g., the type of applications they use, also remains private. In this paper we report on two statistical traffic analysis techniques that can be used to break the second type of protection when applied to SSH tunnels, at least under some restricting hypothesis. Experimental results show how current implementations of SSH can be susceptible to this type of analysis, and illustrate the effectiveness of our two classifiers both in terms of their capabilities in analyzing encrypted traffic and in terms of their relative computational complexity.
Androgens, androgen receptors, antiandrogens and the treatment of prostate cancer. (1997)

Androgens play a major role in promoting the growth of the prostate gland. The DHT-androgen receptor complex, by association with the androgen response elements, specifically promotes this androgenic effect on the genome. Also recognized now, however, is that there is a close relationship between this androgen-mediated signalling pathway and those promoted by peptide growth factors, the crosstalk between the pathways being pivotal to growth regulatory control. This is discussed together with the perceived clinical potential of tyrosine kinase inhibitors for the treatment of prostate cancer, when the intracellular signalling, induced by the growth stimulatory factors, can be repressed.
Luzzu—A Methodology and Framework for Linked Data Quality Assessment (2016)

The increasing variety of Linked Data on the Web makes it challenging to determine the quality of this data and, subsequently, to make this information explicit to data consumers. Despite the availability of a number of tools and frameworks to assess Linked Data Quality, the output of such tools is not suitable for machine consumption, and thus consumers can hardly compare and rank datasets in the order of fitness for use . This article describes a conceptual methodology for assessing Linked Datasets, and Luzzu; a framework for Linked Data Quality Assessment. Luzzu is based on four major components: (1) an extensible interface for defining new quality metrics; (2) an interoperable , ontology-driven back-end for representing quality metadata and quality problems that can be re-used within different semantic frameworks; (3) scalable dataset processors for data dumps, SPARQL endpoints, and big data infrastructures; and (4) a customisable ranking algorithm taking into account user-defined weights. We show that Luzzu scales linearly against the number of triples in a dataset. We also demonstrate the applicability of the Luzzu framework by evaluating and analysing a number of statistical datasets against a variety of metrics. This article contributes towards the definition of a holistic data quality lifecycle, in terms of the co-evolution of linked datasets, with the final aim of improving their quality.
Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats (2013)

Inhibition of SDF-1 following tumor irradiation is a powerful way of improving tumor response of glioblastoma multiforme.
Mechanisms of Oxidative Protein Folding in the Bacterial Cell Envelope (2010)

Disulfide-bond formation is important for the correct folding of a great number of proteins that are exported to the cell envelope of bacteria. Bacterial cells have evolved elaborate systems to promote the joining of two cysteines to form a disulfide bond and to repair misoxidized proteins. In the past two decades, significant advances have occurred in our understanding of the enzyme systems (DsbA, DsbB, DsbC, DsbG, and DsbD) used by the gram-negative bacterium Escherichia coli to ensure that correct pairs of cysteines are joined during the process of protein folding. However, a number of fundamental questions about these processes remain, especially about how they occur inside the cell. In addition, recent recognition of the increasing diversity among bacteria in the disulfide bond-forming capacity and in the systems for introducing disulfide bonds into proteins is raising new questions. We review here the marked progress in this field and discuss important questions that remain for future studies.
Cis-Acting Elements Essential for Light Regulation of the Nuclear Gene Encoding the A Subunit of Chloroplast Glyceraldehyde 3-Phosphate Dehydrogenase in Arabidopsis thaliana (1996)

We report the characterization of cis-acting elements involved in light regulation of the nuclear gene (GapA) that encodes the A subunit of glyceraldehyde 3-phosphate dehydrogenase in Arabidopsis thaliana. Our previous deletion analyses indicate that the -277 to -195 upstream region of GapA is essential for light induction of the beta-glucuronidase reporter gene in transgenic tobacco (Nicotiana tabacum) plants. This region contains three direct repeats with the consensus sequence 5'-CAAATGAA(A/G)A-3' (Gap boxes). Our results show that 2-bp substitutions of the last four nucleotides (AA or GA) of the Gap boxes by CC abolish light induction of the beta-glucuronidase reporter gene in vivo and affect binding of the Gap box binding factor in vitro. We have also identified an additional cis-acting element, AE (Activation Element) box, that is involved in regulation of GapA. A combination of a Gap box trimer and an AE box dimer can confer light responsiveness of the cauliflower mosaic virus 35S promoter containing the -92 to +6 upstream sequence, whereas oligomers of Gap boxes or AE boxes alone cannot confer light responsiveness on the same promoter. These results suggest that Gap boxes and AE boxes function together as the light-responsive element of GapA.
Differences in ceramic–bone interface between surface‐active ceramics and resorbable ceramics: A study by scanning and transmission electron microscopy (1992)

The interface between bioactive ceramics and bone was studied by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The materials were apatite-wollastonite-containing glass ceramic (A-W.GC) as a representative surface-active ceramic, and calcite and beta-tricalcium phosphate (beta-TCP) as resorbable ceramics. Particles of these materials, ranging between about 100 microns and 300 microns in diameter, were implanted into rat tibiae, and specimens were prepared for observation at 8 weeks after implantation. Both SEM and TEM demonstrated that A-W.GC was bonded to bone through a thin Ca-P-rich layer consisting of fine apatite crystals apparently different from those of bone in shape, size, and orientation. Collagen fibers of the bone reached the surface of this layer, and chemical bonding between A-W.GC and the bone was speculated. Calcite and beta-TCP, on the other hand, made direct contact with the bone, and no apatite layer was present at the interface. The surfaces of the implants became rough due to degradation, and bone grew into the finest surface irregularities. However, we were unable to demonstrate any continuity of crystals between the resorbable implants and bone by high-resolution TEM. Accordingly, the bonding strength was considered to be mainly attributable to mechanical interlocking.
Effect of pluronic acid F-127 on the toxicity towards eukaryotic cells of CSA-13, a cationic steroid analogue of antimicrobial peptides (2012)

This work establishes that studies on the toxic effects of synthetic antimicrobials on eukaryotic cells should not only focus on the permeability of the plasma membrane but also on the integrity of the mitochondria.
Wideband and Low-Profile H-Plane Ridged SIW Horn Antenna Mounted on a Large Conducting Plane (2014)

This communication presents a wide-band and low-profile H-plane horn antenna based on ridged substrate integrated waveguide (SIW) with a large conducting ground. The horn antenna is implemented in a single substrate with a thickness of 0.13 λ0 at the center frequency. Despite its low profile, the new H-plane horn antenna achieves a very wide bandwidth by employing an arc-shaped copper taper printed on the extended dielectric slab and a three-step ridged SIW transition. The ridged SIW is critical for widening the operation bandwidth and lowering the characteristic impedance so that an excellent impedance matching from the coaxial probe to the narrow SIW can be obtained over a wide frequency range. Measured VSWR of the fabricated horn antenna is below 2.5 from 6.6 GHz to 18 GHz. The antenna also exhibits stable radiation beam over the same frequency range. It is observed that measured results agree well with simulated ones.
Evaluation of the sublethal effect of tetrachlorantraniliprole on Spodoptera exigua and its potential toxicity to two non-target organisms (2020)

Tetrachlorantraniliprole (TCAP) is a novel anthranilic diamide insecticide that specifically targets the ryanodine receptors of lepidopteran insect species with excellent insecticidal activity. Previous studies have reported the sublethal effects of multiple diamides on several lepidopteran species, whereas the sublethal and non-target effects of TCAP remain largely unknown. We assessed the sublethal effects of TCAP on Spodoptera exigua. We also investigated the effects of TCAP on non-target Harmonia axyridis and Eisenia fetida, S. exigua was more sensitive to TCAP than to chlorantraniliprole, as the LC50 (10.371 μg L-1 at 72 h) of TCAP was relatively lower. Compared with those of the control, sublethal concentrations of TCAP (LC10 and LC30) not only prolonged the duration of the larval and pupal stages as well as the mean generation time but also reduced certain population parameters. On the other hand, TCAP exposure, even at the highest concentration, did not induce toxic effects in H. axyridis ladybugs (1st instar larvae and adults) or E. fetida earthworms. Taken together, our results suggest that TCAP can be used as a novel and promising component of the integrated pest management (IPM) program against S. exigua due to its robust target effects and negligible non-target risks.
Kinoform refraction lens with diffraction calculation (2004)

By direct numerical simulations of the kinoform refractive lens within the quazioptical approach the effects of shape misalinement were investigated. The quazioptical approach was based on numerical integration of parabolic equation for complex wave amplitude by spep-by-step method with "splitting" procedure. The effect of 2pi- shift compensation was calculated for different orders and imperfections. The performance of kinoform lens was compared with the compound refractive lens and thin lens approximation.
Consistent quantitative gene product expression: #1. Automated identification of regenerating bone marrow cell populations using support vector machines (2016)

Identification and quantification of maturing hematopoietic cell populations in flow cytometry data sets is a complex and sometimes irreproducible step in data analysis. Supervised machine learning algorithms present promise to automatically classify cells into populations, reducing subjective bias in data analysis. We describe the use of support vector machines (SVMs), a supervised algorithm, to reproducibly identify two distinctly different populations of normal hematopoietic cells, mature lymphocytes and uncommitted progenitor cells, in the challenging setting of pediatric bone marrow specimens obtained 1 month after chemotherapy. Four-color flow cytometry data were collected on a FACS Calibur for 77 randomly selected postchemotherapy pediatric patients enrolled on the Children's Oncology Group clinical trial AAML1031. These patients demonstrated no evidence of detectable residual disease and were divided into training (n = 27) and testing (n = 50) cohorts. SVMs were trained to identify mature lymphocytes and uncommitted progenitor cells in the training cohort before independent evaluation of prediction efficiency in the testing cohort. Both SVMs demonstrated high predictive performance (lymphocyte SVM: sensitivity >0.99, specificity >0.99; uncommitted progenitor cell SVM: sensitivity = 0.94, specificity >0.99) and closely mirrored manual cell classifications by two expert-analysts. SVMs present an efficient, automated methodology for identifying normal cell populations even in stressed bone marrows, replicating the performance of an expert while reducing the intrinsic bias of gating procedures between multiple analysts. © 2016 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of ISAC.
Successful implementation of compartmentalisation in aquaculture: the production of Atlantic salmon in Iceland (2020)

The designations and denominations employed and the presentation of the material in this article do not imply the expression of any opinion whatsoever on the part of the OIE concerning the legal status of any country, territory, city or area or of
QoS-aware autonomous distributed power control in co-channel femtocell networks (2012)

Femtocells (FCs) are small-area cellular networks deployed over a macrocell (MC) network. Typically, FCs are independent of each other and of the underlying MC, thereby necessitating distributed non-cooperative resource allocation schemes. This paper develops a new distributed autonomous uplink (UL) power control (PC) scheme for femto users (FUs). Our work aims at maintaining the minimum required signal to interference plus noise ratio (SINR) for a maximum number of FUs via distributed QoS-aware stochastic power allocation to FUs. We evaluate the performance of our proposed solution and compare it with existing power allocation techniques. Results show that our scheme yields a significant performance improvement in terms of percentage of satisfied users when compared with these existing solutions.