gebhart/patrepeval huggingface dataset:
Amorphization Strategy Affects the Stability and Supersaturation Profile of Amorphous Drug Nanoparticles (2014)

Amorphous drug nanoparticles have recently emerged as a promising bioavailability enhancement strategy of poorly soluble drugs attributed to the high supersaturation solubility generated by the amorphous state and fast dissolution afforded by the nanoparticles. Herein we examine the effects of two amorphization strategies in the nanoscale, i.e., (1) molecular mobility restrictions and (2) high energy surface occupation, both by polymer excipient stabilizers, on the (i) morphology, (ii) colloidal stability, (iii) drug loading, (iv) amorphous state stability after three-month storage, and (v) in vitro supersaturation profiles, using itraconazole (ITZ) as the model drug. Drug-polyelectrolyte complexation is employed in the first strategy to prepare amorphous ITZ nanoparticles using dextran sulfate as the polyelectrolyte (ITZ nanoplex), while the second strategy employs pH-shift precipitation using hydroxypropylmethylcellulose as the surface stabilizer (nano-ITZ), with both strategies resulting in >90% ITZ utilization. Both amorphous ITZ nanoparticles share similar morphology (∼300 nm spheres) with the ITZ nanoplex exhibiting better colloidal stability, albeit at lower ITZ loading (65% versus 94%), due to the larger stabilizer amount used. The ITZ nanoplex also exhibits superior amorphous state stability, attributed to the ITZ molecular mobility restriction by electrostatic complexation with dextran sulfate. The higher stability, however, is obtained at the expense of slower supersaturation generation, which is maintained over a prolonged period, compared to the nano-ITZ. The present results signify the importance of selecting the optimal amorphization strategy, in addition to formulating the excipient stabilizers, to produce amorphous drug nanoparticles having the desired characteristics.
Synthesis of Aryl-Substituted Triamidoamine Ligands and Molybdenum(IV) Complexes that Contain Them (1998)

Compounds of the type [(ArNHCH2CH2)3N] (Ar = phenyl (H3[1a]), 4-fluorophenyl (H3[1b]), 4-tert-butylphenyl (H3[1c]), 3,5-dimethylphenyl (H3[1d]), 2-methylphenyl (H3[1e]), and mesityl (H3[1f])) have been synthesized by the Pd-catalyzed coupling of (H2NCH2CH2)3N with aryl bromides. Molybdenum methyl complexes containing [1a−d]3- can be prepared by adding 4 equiv of methyllithium to a mixture of the ligand and MoCl4(THF)2; the corresponding chloride complexes are obtained upon addition of 2,6-lutidinium chloride to the methyl complexes.
New Type of Sodium Ion Conducting Solid Electrolyte Based on Lanthanum Oxysulfate (2002)

A new type of sodium ion conducting solid electrolyte was prepared by forming a solid solution. Since the highly conductive phase was successfully preserved in the oxysulfate solid solution, the ion conductivity at 600 and 400°C, was enhanced more than 24 and 40 times, respectively, in comparison to those of pure The oxysulfate solid solution has such a high durability at elevated temperatures as high as 1000°C and also shows a high ion conductivity down to room temperature by preserving the high ion conductive I phase in the framework, the present new ion conducting solid electrolyte is greatly expected to be applied in various fields. © 2002 The Electrochemical Society. All rights reserved.
FaceScape: a Large-scale High Quality 3D Face Dataset and Detailed Riggable 3D Face Prediction (2020)

In this paper, we present a large-scale detailed 3D face dataset, FaceScape, and propose a novel algorithm that is able to predict elaborate riggable 3D face models from a single image input. FaceScape dataset provides 18,760 textured 3D faces, captured from 938 subjects and each with 20 specific expressions. The 3D models contain the pore-level facial geometry that is also processed to be topologically uniformed. These fine 3D facial models can be represented as a 3D morphable model for rough shapes and displacement maps for detailed geometry. Taking advantage of the large-scale and high-accuracy dataset, a novel algorithm is further proposed to learn the expression-specific dynamic details using a deep neural network. The learned relationship serves as the foundation of our 3D face prediction system from a single image input. Different than the previous methods, our predicted 3D models are riggable with highly detailed geometry under different expressions. The unprecedented dataset and code will be released to public for research purpose.
Design and performance evaluation of a whole-body Ingenuity TF PET–MRI system (2011)

The Ingenuity TF PET-MRI is a newly released whole-body hybrid PET-MR imaging system with a Philips time-of-flight GEMINI TF PET and Achieva 3T X-series MRI system. Compared to PET-CT, modifications to the positron emission tomography (PET) gantry were made to avoid mutual system interference and deliver uncompromising performance which is equivalent to the standalone systems. The PET gantry was redesigned to introduce magnetic shielding for the photomultiplier tubes (PMTs). Stringent electromagnetic noise requirements of the MR system necessitated the removal of PET gantry electronics to be housed in the PET-MR equipment room. We report the standard NEMA measurements for the PET scanner. PET imaging and performance measurements were done at Geneva University Hospital as described in the NEMA Standards NU 2-2007 manual. The scatter fraction (SF) and noise equivalent count rate (NECR) measurements with the NEMA cylinder (20 cm diameter) were repeated for two larger cylinders (27 cm and 35 cm diameter), which better represent average and heavy patients. A NEMA/IEC torso phantom was used for overall assessment of image quality. The transverse and axial resolution near the center was 4.7 mm. Timing and energy resolution of the PET-MR system were measured to be 525 ps and 12%, respectively. The results were comparable to PET-CT systems demonstrating that the effect of design modifications required on the PET system to remove the harmful effect of the magnetic field on the PMTs was negligible. The absolute sensitivity of this scanner was 7.0 cps kBq(-1), whereas SF was 26%. NECR measurements performed with cylinders having three different diameters, and image quality measurements performed with IEC phantom yielded excellent results. The Ingenuity TF PET-MRI represents the first commercial whole-body hybrid PET-MRI system. The performance of the PET subsystem was comparable to the GEMINI TF PET-CT system using phantom and patient studies. It is conceived that advantages of hybrid PET-MRI will become more evident in the near future.
Flow Immunoassay Using Solid-Phase Entrapment (1996)

A flow injection immunoassay was performed using a column packed with reversed-phase sorbents to effect separation of the immunoreacted species by entrapping free analyte and allowing antibody-conjugated analyte to pass unretained. Fluorescein-labeled analyte was measured in a competitive assay for the anticonvulsant drug phenytoin. The simplicity of the assay was the greatest advantage of the technique, which allowed for measurement of phenytoin in a 2-min assay time. The reliable detection limit for the assay was 5 nmol L(-)(1) of phenytoin in serum. The columns were regenerated with periodic injections of ethanol solutions to remove the entrapped analyte and prepare the column for subsequent analyses.
Crural diaphragm activation during dynamic contractions at various inspiratory flow rates (1998)

The purpose of this study was to evaluate the influence of velocity of shortening on the relationship between diaphragm activation and pressure generation in humans. This was achieved by relating the root mean square (RMS) of the diaphragm electromyogram to the transdiaphragmatic pressure (Pdi) generated during dynamic contractions at different inspiratory flow rates. Five healthy subjects inspired from functional residual capacity to total lung capacity at different flow rates while reproducing identical Pdi and chest wall configuration profiles. To change the inspiratory flow rate, subjects performed the inspirations while breathing across two different inspiratory resistances (10 and 100 cmH2O . l-1 . s), at mouth pressure targets of -10, -20, -40, and -60 cmH2O. The diaphragm electromyogram was recorded and analyzed with control of signal contamination and electrode positioning. RMS values obtained for inspirations with identical Pdi and chest wall configuration profiles were compared at the same percentage of inspiratory duration. At inspiratory flows ranging between 0.1 and 1.4 l/s, there was no difference in the RMS for the inspirations from functional residual capacity to total lung capacity when Pdi and chest wall configuration profiles were reproduced (n = 4). At higher inspiratory flow rates, subjects were not able to reproduce their chest wall displacements and adopted different recruitment patterns. In conclusion, there was no evidence for increased demand of diaphragm activation when healthy subjects breathe with similar chest wall configuration and Pdi profiles, at increasing flow rates up to 1.4 l/s.
The Influence of Age, Parity, Oral Contraception, Hysterectomy and Menopause on the Prevalence of Urinary Incontinence in Women (1993)

The influence of age, parity, duration of previous oral contraceptive use, hysterectomy and menopause on the prevalence of urinary incontinence was evaluated by means of a postal questionnaire in women 46 to 86 years old who resided in the city of Göteborg, Sweden. A sample of 10,000 women from the 7 birth cohorts of 1900 to 1940 was obtained at random from the population register. The overall response rate was 74.6%. The prevalence of urinary incontinence increased (p < 0.001) in a linear fashion from 12.1% in the 1940 birth cohort to 24.6% in the 1900 birth cohort. The prevalence of urinary incontinence in nulliparous women was 7.7% in the 1930 birth cohort and 5.5% in the 1940 birth cohort. The corresponding figures for women who had experienced 1 delivery were 11.1% and 10.6%, compared to 14.0% and 16.4% among women who had had 3 or more deliveries. Urinary incontinence was more prevalent in women who had undergone hysterectomy (p < 0.05). The prevalence of urinary incontinence was unaffected by the duration of previous oral contraceptive use and there was no evidence to suggest that the prevalence of urinary incontinence increased at the time of the last menstrual period.
Polar direct drive on the National Ignition Facility (2004)

Three recent developments in direct-drive target design have enhanced the possibility of achieving high target gain on the National Ignition Facility (NIF): (1) Laser absorption was increased by almost 50% using wetted-foam targets. (2) Adiabat shaping significantly increased the hydrodynamic stability of the target during the acceleration phase of the implosion without sacrificing target gain. (3) Techniques to reduce laser imprint using pulse shaping and radiation preheat were developed. These design features can be employed for direct-drive-ignition experiments while the NIF is in the x-ray-drive configuration. This involves repointing some of the beams toward the equator of the target to improve uniformity of target drive. This approach, known as polar direct drive (PDD), will enhance the capability of the NIF to explore ignition conditions. PDD will couple more energy to the fuel than x-ray drive. The compressed fuel core can be more easily accessed for high-ρR diagnostic development and for fast-ignitor studies. Polar direct drive is examined in this manuscript using two-dimensional hydrodynamic simulations to determine the level of target performance that can be achieved.
Synthesis and characterization of highly transparent and hydrophobic fluorinated polyimides derived from perfluorodecylthio substituted diamine monomers (2014)

ABSTRACT Two new perfluorodecylthio substituted aromatic diamines, namely 2,4‐diamino‐1‐(1 H ,1 H ,2 H ,2 H ‐perfluorodecathio)benzene (DAPFB) and 2,2'‐ Bis ((1 H ,1 H ,2 H ,2 H ‐perfluorodecyl)thio)[1,1'‐biphenyl]4,4'‐diamine (BPFBD) were synthesized and polycondensed with 4,4′‐(hexafluoroisopropylidene)diphthalic anhydride (6FDA) to produce two new perfluorinated polyimides (PI2 and PI4). The chemical structures of these polyimides were confirmed by Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy and elemental analysis. Two other polyimides (PI1 and PI3) were also synthesized from 6FDA and analogous perfluorodecylthio unsubstituted diamines to investigate the incorporation effect of perfluorodecylthio group on various physical and chemical properties of the synthesized PIs. Compared with PI1 and PI3, PI2 and PI4 exhibited improved solubility, optical transparency, and hydrophobicity, lower moisture absorption, dielectric constant, and thermo‐mechanical stabilities owing to the presence of the perfluorodecylthio side group in the polymer chain. Even though thermo‐mechanical properties of PI2 and PI4 ( : 413 and 404 °C, T g : 220 and 209 °C, tensile strength of 101 and 76 MPa, tensile modulus of 1.7 and 1.5 GPa and elongation at break of 8 and 10%, respectively) were reduced in comparison to PI1 and PI3 but still were good enough for most of the practical applications. Most importantly, the presence of the perfluorodecylthio side group in BPFBD considerably reduced the dielectric constant of PI4 to 2.71 which was quite low as aromatic polyimide. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53 , 479–488
Quantum Computation by Optically Coupled Steady Atoms/Quantum-Dots Inside a Quantum Cavity (1999)

We present a model for quantum computation using $n$ steady 3-level atoms kept inside a quantum cavity, or using $n$ quantum-dots (QDs) kept inside a quantum cavity. In this model one external laser is pointed towards all the atoms/QDs, and $n$ pairs of electrodes are addressing the atoms/QDs, so that each atom is addressed by one pair. The energy levels of each atom/QD are controlled by an external Stark field given to the atom/QD by its external pair of electrodes. Transition between two energy levels of an individual atom/ QD are controlled by the voltage on its electrodes, and by the external laser. Interactions between two atoms/ QDs are performed with the additional help of the cavity mode (using on-resonance condition). Laser frequency, cavity frequency, and energy levels are far off-resonance most of the time, and they are brought to the resonance (using the Stark effect) only at the time of operations. Steps for a controlled-NOT gate between any two atoms/QDs have been described for this model. Our model demands some challenging technological efforts, such as manufacturing single-electron QDs inside a cavity. However, it promises big advantages over other existing models which are currently implemented, and might enable a much easier scale-up, to compute with many more qubits.
Incremental Learning of Object Detectors without Catastrophic Forgetting (2017)

Despite their success for object detection, convolutional neural networks are ill-equipped for incremental learning, i.e., adapting the original model trained on a set of classes to additionally detect objects of new classes, in the absence of the initial training data. They suffer from “catastrophic forgetting”-an abrupt degradation of performance on the original set of classes, when the training objective is adapted to the new classes. We present a method to address this issue, and learn object detectors incrementally, when neither the original training data nor annotations for the original classes in the new training set are available. The core of our proposed solution is a loss function to balance the interplay between predictions on the new classes and a new distillation loss which minimizes the discrepancy between responses for old classes from the original and the updated networks. This incremental learning can be performed multiple times, for a new set of classes in each step, with a moderate drop in performance compared to the baseline network trained on the ensemble of data. We present object detection results on the PASCAL VOC 2007 and COCO datasets, along with a detailed empirical analysis of the approach.
Interface-Induced High-Temperature Superconductivity in Single Unit-Cell FeSe Films on SrTiO <sub>3</sub> (2012)

Searching for superconducting materials with high transition temperature (TC) is one of the most exciting and challenging fields in physics and materials science. Although superconductivity has been discovered for more than 100 years, the copper oxides are so far the only materials with TC above 77 K, the liquid nitrogen boiling point. Here we report an interface engineering method for dramatically raising the TC of superconducting films. We find that one unit-cell (UC) thick films of FeSe grown on SrTiO3 (STO) substrates by molecular beam epitaxy (MBE) show signatures of superconducting transition above 50 K by transport measurement. A superconducting gap as large as 20 meV of the 1 UC films observed by scanning tunneling microcopy (STM) suggests that the superconductivity could occur above 77 K. The occurrence of superconductivity is further supported by the presence of superconducting vortices under magnetic field. Our work not only demonstrates a powerful way for finding new superconductors and for raising TC, but also provides a well-defined platform for systematic study of the mechanism of unconventional superconductivity by using different superconducting materials and substrates.
New Poly(arylene ethynylene)s Consisting of Electron‐Deficient Aryleneimide Units (2005)

Abstract Summary: A new class of poly(arylene ethynylene)s (PAEs) containing an electron‐deficient N ‐alkylphthalimide unit was prepared by means of a Sonogashira reaction. Complete solubility of the PAEs was observed by utilizing a 2,6‐diisopropylphenyl side chain. The chemical structure of the novel soluble polymer 3c was confirmed by NMR spectra, whereas the insoluble polymers were characterized by elemental analysis and IR spectra. Fluorescence measurements of 3c indicate a rigid structure and high symmetry in the excited state. magnified image
On the performance of IEEE 802.15.3c millimeter-wave WPANs: PHY and MAC (2010)

The large amount of unlicensed bandwidth available in the millimeter-wave has enabled very high data rate wireless applications. The IEEE 802.15 Task Group 3c has completed standardization efforts for multi-gigabit data rate communications on both the physical (PHY) and medium access control (MAC) layers. This paper presents a performance evaluation of the PHY and MAC layers of the newly published standard. Packet error rate (PER) and PHY throughput are simulated for different modes based on a typical 60 GHz channel model. The theoretical MAC throughput is calculated for different packet sizes and modes under different link conditions. The link adaptation mechanism is used to analyze the operating range versus data rate. The results show that very high data rates can be achieved over low distances.
Vehicle Environment Sensing by Video Sensors (1999)

<div class="htmlview paragraph">This paper is concerned with the description of a vision system designed for use within future driver assistance systems. The system comprises a high dynamic range CMOS camera, dedicated evaluation hardware based on commercial available PC technology as well as algorithms for the interpretation of video scenes in video real time. The sensor is employed for vehicle environment sensing. Tasks include lane boundary detection, object detection and road sign recognition.</div>
Frequency-Dependent Behavior of the Intervertebral Disc in Response to Each of Six Degree of Freedom Dynamic Loading (2008)

The stiffness increase and phase angle decrease with frequency were greater for deformation modes in which fluid flow effects are thought to be greater.
Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: Executive Summary* (2009)

Martindale, Robert G. MD, PhD; McClave, Stephen A. MD; Vanek, Vincent W. MD; McCarthy, Mary RN, PhD; Roberts, Pamela MD; Taylor, Beth RD; Ochoa, Juan B. MD; Napolitano, Lena MD; Cresci, Gail RD American College of Critical Care Medicine the A.S.P.E.N. Board of Directors Author Information
Synaptic targets of the intrinsic axon collaterals of supragranular pyramidal neurons in monkey prefrontal cortex (2000)

The principal axons of supragranular pyramidal neurons in the cerebral cortex travel through the white matter and terminate in other cortical areas, whereas their intrinsic axon collaterals course through the gray matter and form both local and long-distance connections within a cortical region. In the monkey prefrontal cortex (PFC), horizontally oriented, intrinsic axon collaterals from supragranular pyramidal neurons form a series of stripe-like clusters of axon terminals (Levitt et al. [1993] J Comp Neurol 338:360–376; Pucak et al. [1996] J Comp Neurol 376:614–630). The present study examined the synaptic targets of the intrinsic axon collaterals arising from supragranular pyramidal neurons within the same stripe (local projections). Approximately 50% of the within-stripe axon terminals in monkey PFC area 9 targeted dendritic spines. In contrast, for both the intrinsic axon collaterals that travel between stripes (long-range projections), and the axon terminals that project to other PFC areas (associational projections), over 92% of the postsynaptic structures were dendritic spines (Melchitzky et al. [1998] J Comp Neurol 390:211–224). The other 50% of the within-stripe terminals synapsed with dendritic shafts. Dual-labeling studies confirmed that these within-stripe terminals contacted γ-aminobutyric acid-immunoreactive dendritic shafts, including the subpopulation that contains the calcium-binding protein parvalbumin. The functional significance of the differences in synaptic targets between local and long-range intrinsic axon collaterals was supported by whole-cell, patch clamp recordings in an in vitro slice preparation of monkey PFC. Specifically, the small amplitude responses observed in layer 3 pyramidal neurons during long-range, low-intensity stimulation were exclusively excitatory, whereas local stimulation also evoked di/polysynaptic inhibitory responses. These anatomic and electrophysiological findings suggest that intrinsic connections of the PFC differ from other cortical regions and that within the PFC, feedback (within-stripe) inhibition plays a greater role in regulating the activity of supragranular pyramidal neurons than does feedforward inhibition either between stripes or across regions. J. Comp. Neurol. 430:209–221, 2001. © 2001 Wiley-Liss, Inc.