gebhart/patrepeval huggingface dataset:
A time borrowing selectively clocked skewed logic for high-performance circuits in scaled technologies (2004)

In high performance designs, dynamic circuits, such as domino logic, are used because of their high speed. However, due to its low noise margin, domino circuits do not scale effectively. Skewed logic circuit can be used to achieve design having performance comparable to that of domino but with better scalability. We proposed selectively clocked skewed logic (SCSL) as an alternative to domino logic for high-performance, noise-immune, low-power circuits. Moreover, a time borrowing technique that is usually used in domino designs can also be applied to further improve the performance of SCSL circuits. This paper proposes time borrowing selectively clocked skewed logic (TB-SCSL) style for high-performance applications. Results from the simulation on 16-bit carry lookahead adders (CLA) in 0.25/spl mu/m technology show that TB-SCSL can achieve approximately 15% higher performance compared to the normal SCSL.
Probiotics Blunt the Anti-Hypertensive Effect of Blueberry Feeding in Hypertensive Rats without Altering Hippuric Acid Production (2015)

Previously we showed that feeding polyphenol-rich wild blueberries to hypertensive rats lowered systolic blood pressure. Since probiotic bacteria produce bioactive metabolites from berry polyphenols that enhance the health benefits of berry consumption, we hypothesized that adding probiotics to a blueberry-enriched diet would augment the anti-hypertensive effects of blueberry consumption. Groups (n = 8) of male spontaneously hypertensive rats were fed one of four AIN '93G-based diets for 8 weeks: Control (CON); 3% freeze-dried wild blueberry (BB); 1% probiotic bacteria (PRO); or 3% BB + 1% PRO (BB+PRO). Blood pressure was measured at weeks 0, 2, 4, 6, and 8 by the tail-cuff method, and urine was collected at weeks 4 and 8 to determine markers of oxidative stress (F2-isoprostanes), nitric oxide synthesis (nitrites), and polyphenol metabolism (hippuric acid). Data were analyzed using mixed models ANOVA with repeated measures. Diet had a significant main effect on diastolic blood pressure (p = 0.046), with significantly lower measurements in the BB- vs. CON-fed rats (p = 0.035). Systolic blood pressure showed a similar but less pronounced response to diet (p = 0.220), again with the largest difference between the BB and CON groups. Absolute increase in blood pressure between weeks 0 and 8 tended to be smaller in the BB and PRO vs. CON and BB+PRO groups (systolic increase, p = 0.074; diastolic increase, p = 0.185). Diet had a significant main effect on hippuric acid excretion (p<0.0001), with 2- and ~1.5-fold higher levels at weeks 4 and 8, respectively, in the BB and BB+PRO vs. PRO and CON groups. Diet did not have a significant main effect on F2-isoprostane (p = 0.159) or nitrite excretion (p = 0.670). Our findings show that adding probiotics to a blueberry-enriched diet does not enhance and actually may impair the anti-hypertensive effect of blueberry consumption. However, probiotic bacteria are not interfering with blueberry polyphenol metabolism into hippuric acid.
The Cyclopentenone 15-Deoxy-Δ12,14-Prostaglandin J2 Delays Lipopolysaccharide-Induced Preterm Delivery and Reduces Mortality in the Newborn Mouse (2008)

Intrauterine infection is a common trigger for preterm birth and is also a risk factor for the subsequent development of neurodevelopmental abnormalities in the neonate. Bacterial lipopolysaccharide (LPS) binds to toll-like receptor-4 (TLR-4) to activate proinflammatory signaling pathways, which are implicated in both preterm delivery and antenatal brain injury. The transcription factor nuclear factor-kappaB (NF-kappaB) is a key player in the orchestration of the inflammatory response and has a central role in parturition. Here we show that intrauterine administration of TLR-4-specific LPS to pregnant mice results in the activation of NF-kappaB in the maternal uterus and the fetal brain, up-regulation of proinflammatory proteins cyclooxygenase-2, chemokine ligand 1, ChemoKine (C-C motif) ligand 2, and cytosolic phospholipase A(2) in myometrium, and induction of preterm delivery. 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an antiinflammatory prostaglandin that plays a role in promoting the resolution of inflammation. We report that coadministration of 15d-PGJ(2) and LPS to pregnant mice delays LPS-induced preterm delivery and confers protection from LPS-induced fetal mortality. This is associated with inhibition of myometrial NF-kappaB, cytosolic phospholipase A(2), and c-Jun N-terminal kinase activation, and of inflammatory protein synthesis. Therefore 15d-PGJ(2) has anti-inflammatory effects via inhibition of multiple aspects of inflammation-driven TRL-4 signaling pathway. Thus, 15d-PGJ(2) or compounds with similar antiinflammatory functions may have potential as therapeutic agents in the management of preterm labor with the added advantage of preventing detrimental effects to the fetus that may result from infection/inflammation.
Effects of image interactivity technology adoption on e-shoppers' behavioural intentions with risk as moderator (2009)

This study assessed the impacts of advanced image interactivity technology (IIT) adoption on e-shoppers' behavioural intentions through an integrated model. Also, we investigated the mediating role of e-shopping satisfaction and examined the moderating effects of perceived risk on e-shoppers' responses towards e-tailer through both experiential value and e-shopping satisfaction. The proposed model was supported by the online survey data from 302 participants with experience in browsing an apparel retail Web site. The results indicate that telepresence has significant effects on utilitarian value and hedonic value, respectively. Furthermore, these two values have strong impacts on e-shopping satisfaction, which, in turn, is significantly related to e-shoppers' intentions to purchase from and rebrowse the e-tailer Web site. Besides, e-shopping satisfaction completely mediates the effects of its antecedents on behavioural intentions and the moderating effects of perceived risk are not significant as expected. Finally, managerial implications and research limitations are also discussed in this article.
Physics of Resonance in a Supersonic Forward-Facing Cavity (1998)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Failure prediction for long length optical fiber based on proof testing (1982)

A new method for reliability assurance of long length optical glass fibers is presented. This method is based on a simple equation by fracture-mechanics theory and provides failure probability prediction for fibers after proof testing. The prediction is made by using dynamic fatigue data obtained by simple tensile tests and failure number during proof testing. The experimental results are found to be in good agreement with those predicted by the theory, and it is verified that the method is useful to make reliability assurance of long optical fibers for long- term use.
Definitive Molecular Level Characterization of Defects in UiO‐66 Crystals (2015)

The identification and characterization of defects, on the molecular level, in metal-organic frameworks (MOFs) remain a challenge. With the extensive use of single-crystal X-ray diffraction (SXRD), the missing linker defects in the zirconium-based MOF UiO-66, Zr6 O4 (OH)4 (C8 H4 O4 )6 , have been identified as water molecules coordinated directly to the zirconium centers. Charge balancing is achieved by hydroxide anions, which are hydrogen bonded within the pores of the framework. Furthermore, the precise nature of the defects and their concentration can be manipulated by altering the starting materials, synthesis conditions, and post-synthetic modifications.
Combination of radiofrequency ablation and immunotherapy (2007)

The enhancement of immune response against tumor antigens has shown some efficacy when used as a single mode of systemic treatment in patients with late stage disease. Novel strategies of active immunotherapy could be more effective in patients with less advanced disease who receive standard therapies supporting concomitant stimulation of the immune system. Radio-Frequency Ablation (RFA) is a minimally invasive technique which is used as standard local therapy of primary and metastatic liver tumors. Tumor ablation by RFA induces effects important for boosting anti-tumor immune responses. Tumor cell necrosis generates a permanent immunogenic source of tumor antigens. These antigens can be uptaken, processed and presented by dendritic cells for effective immunization without requirement for ex vivo antigen loading. Further immune activation can be originated by RFA through induction of heat shock proteins on tumor cells, acute phase response which causes the release of pro-inflammatory cytokines, and mobilization of antigen presenting cells and effector lymphocytes. Thus, RFA can facilitate immune responses to tumor antigens driven by active immunotherapy. On the other hand, immunotherapy is expected to eradicate residual disease after RFA and prevent tumor recurrences. The combination of RFA and active immunotherapy may well have synergistic effects for cancer treatment.
Membrane Potential-Driven Protein Import into Mitochondria (2000)

The transport of preproteins into or across the mitochondrial inner membrane requires the membrane potential Deltapsi across this membrane. Two roles of Deltapsi in the import of cleavable preproteins have been described: an electrophoretic effect on the positively charged matrix-targeting sequences and the activation of the translocase subunit Tim23. We report the unexpected finding that deletion of a segment within the sorting sequence of cytochrome b(2), which is located behind the matrix-targeting sequence, strongly influenced the Deltapsi-dependence of import. The differential Deltapsi-dependence was independent of the submitochondrial destination of the preprotein and was not attributable to the requirement for mitochondrial Hsp70 or Tim23. With a series of preprotein constructs, the net charge of the sorting sequence was altered, but the Deltapsi-dependence of import was not affected. These results suggested that the sorting sequence contributed to the import driving mechanism in a manner distinct from the two known roles of Deltapsi. Indeed, a charge-neutral amino acid exchange in the hydrophobic segment of the sorting sequence generated a preprotein with an even better import, i.e. one with lower Deltapsi-dependence than the wild-type preprotein. The sorting sequence functioned early in the import pathway since it strongly influenced the efficiency of translocation of the matrix-targeting sequence across the inner membrane. These results suggest a model whereby an electrophoretic effect of Deltapsi on the matrix-targeting sequence is complemented by an import-stimulating activity of the sorting sequence.
Specifying a middleware for distributed embedded vehicle control systems (2014)

The software of electric / electronic vehicle control systems is static in current series vehicles. Most of the systems do not allow maintenance or functional updates, especially in the field of driver assistance systems. Main causes are the testing effort for a software release and the wide variety of different configurations in different vehicle models. In this paper we take a closer look at the requirements for a middleware which allows such updates, verifies new software versions, and adds reconfiguration mechanisms for singular control units and distributed sets of control units. To derive the requirements we consider the general vehicular context with limitations in space, electric power, processing power, and costs together with four exemplary road vehicle control applications (cruise control, automatic parking, stability control, force feedback), and a full x-by-wire target vehicle for implementing these applications. The analysis of these three different sources of requirements results in desired middleware functionalities and requirements, especially concerning runtime timings and update timings. The requirements cover an update functionality with integrated verification, the exchange of applications on singular control units, and the degradation of functionality by switching between control units.
EEPROM device as a reconfigurable analog element for neural networks (2003)

An investigation into the use of EEPROMs (electrically erasable programmable read-only memories) for analog storage is presented, with special consideration given to the problem of reconfigurable weight storage in neural net implementations. Control of either programming voltage or programming time can be used to program the threshold voltage of industry-standard digital EEPROMs to any analog value. Variations in the programming curves of different devices on the same chip as well as changes in the programming curve of a single device with age suggest the need for feedback in any EEPROM-based analog programming strategy. EEPROM charge retention appears to be very good in the analog range and, to first order, temperature compensation of EEPROMs is no more complicated than that for conventional MOS circuits. A particular analog programming scheme which provides about 8 b of resolution per EEPROM device is presented, and the potential uses of EEPROMs in neural net designs are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Protein Molecular Mass to 1 Da by <sup>13</sup>C, <sup>15</sup>N Double-Depletion and FT-ICR Mass Spectrometry (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTProtein Molecular Mass to 1 Da by 13C, 15N Double-Depletion and FT-ICR Mass SpectrometryAlan G. Marshall, Michael W. Senko, Weiqun Li, Ming Li, Stephanie Dillon, Shenheng Guan, and Timothy M. LoganView Author Information Center for Interdisciplinary Magnetic Resonance National High Magnetic Field Laboratory 1800 E. Paul Dirac Drive Florida State University, Tallahassee, Florida 32310 Cite this: J. Am. Chem. Soc. 1997, 119, 2, 433–434Publication Date (Web):January 15, 1997Publication History Received26 August 1996Published online15 January 1997Published inissue 1 January 1997https://pubs.acs.org/doi/10.1021/ja9630046https://doi.org/10.1021/ja9630046rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views531Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon,Ions,Mass spectrometry,Monomers,Peptides and proteins Get e-Alerts
Geomechanical analysis of a welding salt layer and its effects on adjacent sediments (2016)

We simulate welding of the source layer of a salt diapir with a forward finite-element model and study stresses and deformation in the salt layer and the diapir, as well as in their adjacent sediments. Welded salt layers are abundant in mature salt basins, where most or all of the salt has withdrawn into diapirs. However, there is little understanding of the stress field in these layers and their adjacent sediments. We show that salt flow along the source layer leads to significant stress anomalies inside the layer and in adjacent sediments. In the source layer, salt pressure becomes higher than overburden stress in nearly welded areas and becomes lower than overburden stress in adjacent thicker areas. When the source layer welds, stresses increase significantly in sediments near the weld tip, which helps compaction of these sediments and possibly their fracturing and faulting. Our model illustrates that all sediments overlying the weld experience this stress increase and the associated material changes as the weld tip propagates along the weld. We present natural examples fitting our predictions and discuss the importance of our results for the exploration, characterization, and production of reservoirs near welded salt layers.
Low holotranscobalamin II is the earliest serum marker for subnormal vitamin B<sub>12</sub> (cobalamin) absorption in patients with AIDS (1990)

In AIDS, as previously found in pernicious anemia (PA), the earliest serum marker of subnormal vitamin B12 (cobalamin) absorption, and therefore of negative B12 balance, is low serum holotranscobalamin II (holo-TC II; B12-TC II) despite normal total serum B12 level, normal serum homocysteine, and normal classic (oral free radio-B12) Schilling test. This may be accompanied by subtle and insidious damage to hematopoietic, immunologic, neuropsychiatric, nutritional and alimentary systems, confirmed by correction on therapeutic trial with B12 therapy. Our studies suggest such selective B12 deficiency occurs in about half of the HIV-1 infected, in part due to frequent depression of B12 absorption by HIV-1 attack on the gastric mucosa and/or opportunistic infection attack on the small bowel, and in part due to a telescoping of the continuum of the stages of negative B12 balance in relation to damage to B12 delivery by the infective and/or systemic disease process. In AIDS, when total serum B12 is normal despite tissue depletion of B12, if the classic Schilling test does not reveal subnormal food B12 absorption, the food Schilling test does. We hypothesize that DNA-synthesizing cells of the hematopoietic, immunologic, neurologic and other systems which have surface receptors solely for holo-TC II, and which have low B12 stores, rapidly become dysfunctional due to B12 deficiency when holo-TC II is low, while cells (such as liver cells) which also have surface receptors for holohaptocorrin (B12-haptocorrin) remain B12-replete. We believe this to be another example of the concept of selective nutrient deficiency in one cell line but not another.
Multi-Channel 40 Gbit/s NRZ-DPSK Demodulation Using a Single Silicon Microring Resonator (2010)

We comprehensively analyze the demodulation of wavelength division multiplexed (WDM) non return-to-zero differential phase-shift keying (NRZ-DPSK) signals by a single microring resonator. Simultaneous demodulation of multiple 40 Gbit/s WDM NRZ-DPSK channels is demonstrated using a single silicon microring resonator with free spectral range (FSR) of 100 GHz. Bit error measurements show very good performance for both through and drop port demodulations for all channels, and the drop port demodulation exhibits better wavelength detuning tolerance than for demodulation using a Mach-Zehnder delay interferometer (MZDI).
Nucleotide Sequence Coding for the Respiratory NADH Dehydrogenase of <i>Escherichia coli</i> (1981)

The nucleotide sequence of the structural gene coding for the respiratory NADH dehydrogenase of Escherichia coli has been determined by the chain-termination method. The reading frame for the protein starts with the unusual initiation codon UUG and predicts an amino acid sequence of 434 residues (Mr = 47 304). The reading frame was confirmed by protein chemical studies including determination of the N-terminal sequence of the protein. The product made in vivo was found to have threonine as its N-terminal residue, indicating that the initiating N-formylmethionine had been removed by post-translational processing.
Effective Authentication Technique for Distributed Denial of Service Attacks in Wireless Local Area Networks (2012)

Problem statement: In 802.11-based Wireless LAN (WLAN), there is an mproved risk of security attacks. To defeat concealed attacks, there is a necessity to authenticate both access points and wireless stations. Approach: We propose a defensive technique for DDoS attack in WLAN. This authentication technique includes an Authentication Server (AS) in addition to the Wireless Station (WS) and Access Point (AP). Results: The authentication server holds both normal and attacker databases. The attacker database can be constructed from the outcome of fuzzy decision making. After WS and AP registers itself with AS, WS sends authentication request message to AS through the nearest AP. Before granting the session key for the WS, the AS checks the occurrence of WS in the attacker database. If it is found to be an attacker, AS denies the session key for the WS, there by isolating the WS from further communications. In order to prevent the authentication request flooding attacks, traffic pattern filtering rule is implemented. Conclusion/Recommendations: By simulation results, we show that the proposed technique is more efficient defensive mechanism against DDoS attack.
An Optimal Resource Allocation Mechanism in Vehicular MEC Systems (2019)

Task offloading in vehicular networks is an effective technology to promote vehicular service quality through offloading computation tasks to remote servers. In order to reduce task processing latency and increase the task processing reliability, mobile edge computing(MEC) is introduced into vehicular networks. MEC with its distributed computation feature can decrease onboard task processing delay and enhance quality of user experience in latency-sensitive tasks. In this paper, we propose a mechanism to minimize the total task processing latency among a set of vehicles in a time slot by using a resource-matching integration perspective. The method considers the computation ability of each road side units in a road segment and the total offloading latency of a set of vehicles to get a best resource allocation plan and achieve onboard task offloading. Numerical results show that our proposed scheme can reduce the total network latency and significantly improve the system performance.
Antibodies interfering with the type 3 muscarinic receptor pathway inhibit gastrointestinal motility and cholinergic neurotransmission in Sjögren's syndrome (2011)

Our results indicate that anti-M3R autoantibodies have the potential to mediate multiple dysfunctions of the GI tract in primary SS, ranging from reduced esophageal motor activity to altered colonic motility. We hypothesize that altered GI motility forms part of a broader autonomic dysfunction mediated by pathogenic anti-M3R autoantibodies in primary SS.
Theoretical Concepts and the Emerging Role of Taxanes in Adjuvant Therapy (2001)

The proven benefits of adjuvant chemotherapy on disease-free and overall survival in breast cancer can be explained by concepts of cell kill. Interventions which result in greater log kill can be expected to produce improved clinical results. The application of log-kill concepts to human breast cancer growth, which appears to follow Gompertzian kinetics, suggests not only that the use of non-cross-resistant drugs is important, but that dose-dense schedules may have an advantage over conventional schedules of drug administration. Sequential therapy may allow dose-dense administration of cytotoxic agents and encourage the integration of new biological agents into combination regimens, particularly with the taxanes. Ongoing trials in these concepts are reviewed.