gebhart/patrepeval huggingface dataset:
Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis (2008)

Multiple signaling proteins are activated in pancreatic duct cell carcinogenesis including those associated with the ERK, PKB/AKT, mTOR and STAT3 pathways. The ERK pathway activation appears also increased in duct epithelia adjacent to carcinoma, suggesting tumor micro-environmental effects.
The molecular basis of male sexual differentiation (2000)

Male sexual differentiation is the result of complex mechanisms involving developmental genetics and endocrinology. Formation of the bipotential gonads and subsequently the testes is dependent on a series of sex chromosome-linked and autosomal genes. The testes secrete both peptide and steroid hormones essential for the formation of internal and external genitalia. Hormone action is mediated via specific receptors, functioning as transcription regulators. Disruption of these genetic events leads to sexual dimorphism involving external and internal genitalia, and may also interfere with the development of other organs.
The use of 16S rRNA-targeted oligonucleotide probes to study competition between ruminal fibrolytic bacteria: development of probes for Ruminococcus species and evidence for bacteriocin production (1994)

A total of six oligonucleotide probes, complementary to the 16S rRNA, were evaluated for quantitative and determinative studies of Ruminococcus albus and Ruminococcus flavefaciens. On the basis of specificity studies, probes for R. albus (probe RAL196) and R. flavefaciens (probe RFL196) were selected to quantitate these species in mixed culture. In combination with a Fibrobacter succinogenes S85 subspecies probe (SUB1) and a domain Bacteria (formerly kingdom Eubacteria) probe (EUB338), they were used to quantitate these species competing in mixed cultures for cellobiose as the carbon source. In dicultures containing R. albus 8 and F. succinogenes S85, competition was not observed. However, R. flavefaciens FD-1 eventually outcompeted F. succinogenes S85 when cellobiose was the substrate. When R. albus 8 and R. flavefaciens FD-1 were grown together on cellobiose medium, R. albus 8 outcompeted R. flavefaciens FD-1, resulting in undetectable R. flavefaciens 16S rRNA only 1 to 3 h after inoculation, suggesting production of an antagonistic compound by R. albus 8 during rapid growth on soluble substrates. Further, when R. albus 8, R. flavefaciens FD-1, and F. succinogenes S85 were grown together in a triculture, R. flavefaciens FD-1 16S rRNA was detectable for only 2 h after inoculation, while R. albus 8 and F. succinogenes S85 showed a similar competition pattern to that of the dicultures. The results show that the Ruminococcus probes were effective in the measurement of relative populations of selected R. albus and R. flavefaciens strains during in vitro competition studies with F. succinogenes.(ABSTRACT TRUNCATED AT 250 WORDS)
A NEW PSEUDO-DIFFERENTIAL TRANSMISSION SCHEME FOR ON-CHIP AND ON-BOARD INTERCONNECTIONS (2008)

A new type of pseudo-differential link uses an interconnection comprising a return conductor wider than the transmission conductors, whereas conventional pseudo-differential links use a common conductor similar to the transmission conductors. This signaling scheme, referred to as the ZXnoise method, implements a particular type of termination and provides low reflections and a good protection against external crosstalk, thanks to the remarkable form of the characteristic impedance matrix of the interconnection. A simulation shows that the ZXnoise method is capable of high performances when a transmitting circuit producing a reduced common-mode current is used.
Complex Biochemistry and Biotechnological Production of Betalains (2011)

The demand for natural food colourants is increasing because of public awareness of their health benefits.Betalains are nitrogen-containing plant pigments whose colours range from red-violet betacyanins to yellow betaxanthins.They are used for colouring dairy products, meat and frozen desserts.Betalains have attracted additional interest because of their antioxidative, anti-inflammatory and anticarcinogenic properties.The main source of commercially produced betalains is red beet root, but alternative sources are found in plants from the Amaranthaceae and Cactaceae families.Another alternative source is plant cell culture in bioreactors, although optimization of pigment production seems necessary.In this paper we synthesize the results of recent studies on betalain biosynthesis, chemical properties, sources, biotechnology and applications.
Delayed Vision Loss Post Assault-Induced Zygomatic Fracture Repair in a Patient with an Ipsilateral Anterior Clinoid Process Pneumatization, A Case Report (2023)

A 27-year-old male presented one week after surgical repair of his fractured left zygomatic arch, 5 weeks post-assault, complaining of persistent blurred vision in the left eye and worsening migraine headaches. Magnetic resonance images (MRI) revealed no intra-orbital pathologies or optic neuropathy but demonstrated a clearly delineated air-filled space of the left anterior clinoid process (ACP). No vision threatening pathologies were identified and surgical treatment was not recommended. His blurred vision remained at 6-month follow up. We report a case of delayed vision loss and headache post zygomatic fracture repair surgery in patient with a confirmed ipsilateral ACP pneumatization.
Multiple-dose quazepam kinetics (1984)

Quazepam, a benzodiazepine hypnotic, was studied in normal subjects to evaluate steady-state kinetics of quazepam and of its major active plasma metabolites, 2-oxoquazepam and N-desalkyl-2-oxoquazepam, after 15 mg once daily by mouth for 14 days. The kinetics of quazepam and 2-oxoquazepam can be best described by a two-compartment open model with first-order absorption/formation kinetics. Quazepam was rapidly absorbed and its two major plasma metabolites appeared very quickly in systemic circulation. The elimination t 1/2s of quazepam, 2-oxoquazepam, and N-desalkyl-2-oxoquazepam were 41, 43, and 75 hr. Steady-state levels were predictable from the kinetic data and were reached by the seventh dose for quazepam and 2-oxoquazepam and by the thirteenth dose for N-desalkyl-2-oxoquazepam. These kinetic profiles may explain the clinical hypnotic effect of quazepam--rapid induction of sleep and long duration of clinical action without appreciable rebound insomnia.
Regulation of Bovine Bone Cell Proliferation by Fibroblast Growth Factor and Transforming Growth Factorβ (1988)

We have tested the hypothesis that basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) regulate the proliferation of osteoblast-like cells. Cells which migrated from central bone explants of fetal calf calvaria expressed markers characteristic of the osteoblast phenotype, including osteocalcin (bone Gla protein) secretion and increased cAMP production in response to treatment with PTH. Bone cells proliferated in response to bFGF in a dose- and time-dependent pattern (ED50 = 60 pg/ml media). bFGF increased both the rate of bone cell proliferation (1.7-fold above controls) and final cell density at confluence (3-fold above controls). Acidic FGF (aFGF) exerted comparable effects though with lesser potency (ED50 = 2 ng/ml). In addition to its mitogenic effect, bFGF increased the osteocalcin content of conditioned media, suggesting that bFGF also modulates the function of osteoblast-like cells. Although TGF beta did not stimulate bone cell proliferation, it potentiated the mitogenic effects of aFGF and bFGF. In the presence of bFGF (0.7 ng/ml) the response to TGF beta was dose-dependent (ED50 = 1.7 ng/ml), with maximal stimulation at 5 ng/ml. These results demonstrate that aFGF and bFGF are mitogenic for bone cells in vitro. Furthermore, TGF beta potentiates the effects of bFGF and aFGF on the proliferation of bone cells. Since these growth factors are present in bone tissue in vivo, these data support the proposal that FGF and TGF beta may participate in the regulation of bone formation.
Finite state machine implementation for left ventricle modeling and control (2019)

The proposed approach allows for personalized data, revealed through an individualized clinical pressure-volume analysis, to be simulated in silico. The computational model architecture enables this control structure to be executed on deterministic systems that govern experimental left ventricles. This provides a mock circulatory system with the ability to investigate the pathophysiology for a specific individual by replicating the exact pressure-volume relationship defined by their left ventricular functionality; as well as perform predictive analysis regarding changes in preload, afterload, and contractility in time.
Real-Time Algorithm for Image Segmentation Based on the Morphological Reconstruction (2005)

The segmentation algorithm described here, has the facility of locating contiguous bodies which are brighter (alternatively darker) than the immediate surrounding areas. The algorithm is based on the reconstruction algorithm from morphological mathematics; this algorithm seeks to delineate areas in the image which, in morphological or topological terms (in three dimensional space), represent hills or plateaus. As such, the algorithm uses information about the the relationship of a pixel to its neighboring pixels rather than just using the aggregate gray level statistics as do other algorithms. A usual, pipeline implementation based on cellular automata results in art iterative process. Instead, the real-time implementation presented here is a serial algorithm.
Inhibition of Respiratory Syncytial Virus Replication <i>in vitro</i> by a Pyrazole Dicarboxamide Analogue of Ribavirin (1994)

1-β-D-Ribofuranosylpyrazole-3,4-dicarboxamide (GR-92938X) was found to be an inhibitor of respiratory syncytial virus in vitro, with a potency equivalent to that of ribavirin. The compound was more specific as, unlike ribavirin, it did not inhibit influenza A, influenza B or parainfluenza 2 virus. It was phosphorylated by adenosine kinase and, unlike ribavirin, it did not inhibit cellular inosine monophosphate dehydrogenase.
Thermosetting Adhesive Resins from Whey and Whey Byproducts (1989)

The disposal of whey and whey byproducts derived from the cheese industry represents a serious economic and enviromental problem due to the high biological oxygen demand of lactose-the major constituent of whey solids. Maillard and caramelization reactions associated with the thermal degradation and polymerization of the milk sugar can be exploited to convert lactose in whey to a thermosetting resin that can serve as an adhesive for binding solid lignocellulosic materials. The resin synthesis may be accomplished in one step using a batch reaction (Phase I) or prepared more readily using a continuous plugflow reaction with a two-step synthesis (Phase II). Resins have been shown to perform well as adhesives for sawdust and/or rice hull reinforced boards. Preliminary thermal studies indicate an exothermic polymerization occurring at around 200 ⪚C for the Phase I resin preparation.
Short Text Classification based on feature extension using The N-Gram model (2015)

With the rapid development of Web2.0, more and more people like to show their life or opinions on social media websites or forums, such as Weibo, Twitter and Tianya, which produce masses of short texts. In order to manage these short texts effectively, Short Text Classification becomes an important branch of Text Classification. However, because of the short text length, the lack of signals, and the sparseness of features, it is very difficult to achieve high quality classification by using conventional methods. This paper proposes a novelty feature extending method based on the N-Gram model to solve the problem of feature sparseness. From continuous word sequences in the train set, we extract n-grams as our feature extension mode library. Then using features showing in the short texts, we can compute the appearance probability of other words that do not exist in original texts. We use the data set collected from Sina Weibo to carry out our extension method. After extending features of the original short texts, we use the Naïve Bayes algorithm to train and evaluate a classifier. We use precision, recall and F1-Score to evaluate our work. The result shows that the extension method based on the N-Gram model can improve classification performance observably.
C1Q receptors on cultured human gingival fibroblasts: analysis of binding properties. (1983)

The interaction of the purified C1q component of human C with synchronized, quiescent human gingival fibroblasts was investigated, and the presence of a specific binding site was demonstrated. Quantitative binding studies with radioiodinated C1q showed that binding was specific, saturable, and reversible upon addition of unlabeled C1q or by increasing the salt concentration. Scatchard plot analysis of the data yielded an affinity constant of 2 X 10(7) M-1 for all cell strains examined. The capacity for C1q binding varied among the eight cell strains examined. The number of binding sites per cell ranged from 2.6 to 17.7 X 10(6) with an average of 8.4 X 10(6). The receptor was insensitive to trypsin digestion, and it bound the collagen-like portion of the C1q molecule. Specific immunofluorescence staining showed that virtually all the viable cultured fibroblasts were able to bind added C1q. Flow cytometric analysis demonstrated a spectrum of fluorescence intensity among the cell strains, and there was a positive correlation between fluorescence intensity and the number of binding sites detected by using radiolabeled C1q.
Reduced Body Weight and Increased Energy Expenditure in Transgenic Mice Over-Expressing Soluble Leptin Receptor (2010)

These results are consistent with the role of OBRe as a leptin binding protein in regulating leptin's bioavailability and activity.
ICT 기반 콘텐츠에 대한 스토리텔링 활용 방안 (2015)

This writing would have discussion about the best using of storytelling based on ICT which has nowadays spotlight. This also would consider about change of contents environment surrounding storytelling. There is discussion about storytelling for last ten years. But we faced limitation about cultural contents thesedays. Changes surrounding contents convert discourse to wide contents. As a result, we need to consider about these changes when it comes to talk about contents. These contents changes may result from ICT development. ICT could affect on all kind of social, culture, industrial fields. The contents which provided through the platform based on ICT would lead earlier paradigm of storytelling discourse. To renew about storytelling, it is necessary to understand and study about contents based on ICT. This considers the way of utilizing storytelling about digital tour, Web 3D on ICT. Through these kinds of process, we would ready to start to think about possibility of utilizing storytelling based on ICT, provide new form of discussion for new area about storytelling.
Scale-up of <i>N</i>-alkylation reaction using phase-transfer catalysis with integrated separation in flow (2018)

Scaling-up phase-transfer catalysis in flow.
Gold nanoparticles confined in the interconnected carbon foams with high temperature stability (2012)

Gold nanoparticle-carbon foam composites with highly-dispersed gold nanoparticles confined in the cavities were prepared. The gold nanoparticles are effectively separated from each other by permeable carbon shells, which show high temperature stability and were fully accessible to the substrate.
Direct Freeform Fabrication of Seeded Hydrogels in Arbitrary Geometries (2006)

A major challenge in tissue engineering is the generation of cell-seeded implants with structures that mimic native tissue, both in anatomic geometries and intratissue cell distributions. By combining the strengths of injection molding tissue engineering with those of solid freeform fabrication (SFF), three-dimensional (3-D) pre-seeded implants were fabricated without custom-tooling, enabling efficient production of patient-specific implants. The incorporation of SFF technology also enabled the fabrication of geometrically complex, multiple-material implants with spatially heterogeneous properties that would otherwise be challenging to produce. Utilizing a custom-built robotic SFF platform and gel deposition tools, alginate hydrogel was used with calcium sulfate as a crosslinking agent to produce pre-seeded living implants of arbitrary geometries. The process was determined to be sterile and viable at 94 +/- 5%. The GAG and hydroxyproline production was found to be similar to that of other implants fabricated using the same materials with different shaping methods. The geometric fidelity of the process was quantified by using the printing platform as a computerized measurement machine (CMM); the RMS surface roughness of printed samples in the z-dimension was found to be 0.16 +/- 0.02 mm.
Preparation and characterization of bismaleimide monomers with various structures (2012)

A series of bismaleimide monomers (BMI) with various structures containing flexible linkages was prepared and structural characterization of these compounds was carried out by elemental analysis, Fourier transform infrared spectroscopy, and 1H−NMR spectroscopy. The thermal behavior of these monomers (BMI(1–4)) was investigated by differential scanning calorimetry, polarized light microscopy and thermogravimetric analysis. The reactivity of the bismaleimide compounds is influenced by chemical nature of the bridge unit between the maleimide rings. The monomers were soluble in several organic solvents, the 10% weight loss temperatures were above 500 °C, and char yield at 700 °C ranged between 46 and 58% in nitrogen atmosphere. Birefringence in melting state was observed for two bismaleimides (BMI-3 and BMI-4) which could indicate a possible thermotropic liquid crystalline behavior.
A deep silicon via (DSV) ground for sige power amplifiers (2010)

A low parasitic inductance ground for SiGe power amplifiers has been implemented using a deep silicon via (DSV). The advantages and opportunities that this approach opens for the power amplifier (PA) design process are demonstrated. DSV resistance, inductance, and data from IV sweep, RF characterization and load pull measurements are analyzed.
Wi-Fi Indoor Positioning System-Advanced Finger Printing Method (2017)

The Wi-Fi-indoor positioning System is the major part to make the IOT real without using more expensive resources and external Hardware. This paper will give you brief introduction about the algorithms and method which can help us to achieve the position of an individual accurately, the main problem with majority of the methods is that they require the additional hardware to install or the complexity of the system is off the charts which will require more time and money .Later in the paper choose one of the method which is accurate and low cost but the only disadvantage is the labour cost or the amount of hard work it require.
Early Therapy Improves Outcomes of Exacerbations of Chronic Obstructive Pulmonary Disease (2004)

Treatment of chronic obstructive pulmonary disease (COPD) exacerbations improves outcomes; however, responses to treatment are variable, and patients with COPD often delay presentation or fail to seek therapy. The impact on exacerbation outcomes, hospitalization, and health status of delaying or failing to seek treatment is poorly understood. We studied between 1996 and 2002 a cohort of 128 patients with COPD, mean (SD) FEV(1) of 1.07 (0.43) L. Patients recorded respiratory symptoms daily and reported exacerbations to the outpatient-based study team or to their primary care physician; 1,099 exacerbations were recorded by the patients, of which 658 were reported to a physician. The time between exacerbation onset and treatment was a median (interquartile range) of 3.69 (2.0-5.57) days, and the exacerbation recovery time was 10.7 (7.0-14.0) days. Earlier treatment was associated with a faster recovery (regression coefficient 0.42 days/day delay) (confidence interval, 0.19-0.65; p < 0.001). Patients who reported a higher proportion of exacerbations for treatment had better health-related quality of life than those patients with more untreated exacerbations (rho = -0.22, p = 0.018). Failure to report exacerbations was associated with an increased risk of emergency hospitalization (rho = 0.21, p = 0.04). Patient recognition of exacerbation symptoms and prompt treatment improves exacerbation recovery, reduces risks of hospitalization, and is associated with a better health-related quality of life.
A new approach to predicting postconcussion syndrome after mild traumatic brain injury based upon eye movement function (2008)

Following on from our earlier findings of a close relationship between motor function and outcome after mild traumatic brain injury (mTBI), this study examined whether it might be possible to predict poor recovery in the form of postconcussion syndrome (PCS) based upon early eye and arm motor function. Within 1 week post-injury, we assessed 37 mTBI patients on measures of saccades, oculomotor smooth pursuit, upper-limb visuomotor function, neuropsychological status, and self-reported health condition. At 3 months, 8 patients met the criteria for PCS. Using discriminant function analyses, we examined whether this future PCS-group could be identified prospectively based on motor function, neuropsychological status, and self-reported health condition at 1 week post-injury. Early eye movement function was the most effective in distinguishing between PCS and non-PCS patients, achieving a sensitivity and specificity of 100% in the present sample. This was followed by self-reported early health condition (sensitivity: 87%, specificity: 97%), early upper-limb motor performance (87%, 97%), neuropsychological function (62%, 100%), and age, gender, education and clinical measures of trauma severity (37%, 87%). Leave-one-out validation analyses confirmed eye movements as the most robust discriminator (sensitivity: 62%, specificity: 97%). Assessment of eye movement function after mTBI may contribute to a prospective identification of patients who develop PCS, supporting the targeting of early health-care intervention.
Glycerol conversion to 1, 3-Propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri (2011)

In this work, Lactobacillus reuteri has been metabolically engineered for improving 1, 3-propanediol (1, 3-PD) production by the expression of an Escherichia coli alcohol dehydrogenase, yqhD, that is known to efficiently convert the precursor 3-hydroxypropionaldehyde (3-HPA) to 1, 3-PD. The engineered strain exhibited significantly altered formation rates for the product and other metabolites during the fermentation. An increase in the 1, 3-PD specific productivity of 34% and molar yield by 13% was achieved in the clone, relative to the native strain. A concomitant decrease in the levels of toxic intermediate, 3-HPA, was observed, with the specific productivity levels being 25% lesser than that of the native strain. Interestingly, the recombinant strain exhibited elevated rates of lactate and ethanol formation as well as reduced rate of acetate production, compared to the native strain. The preferential utilization of NADPH by YqhD with a possible decrease in the native 1, 3-PD oxidoreductase (NADH-dependent) activity, could have resulted in the diversion of surplus NADH towards increased lactate and ethanol productivities.