gebhart/patrepeval huggingface dataset:
<i>Arabidopsis</i>Nuclear-Encoded Plastid Transit Peptides Contain Multiple Sequence Subgroups with Distinctive Chloroplast-Targeting Sequence Motifs (2008)

The N-terminal transit peptides of nuclear-encoded plastid proteins are necessary and sufficient for their import into plastids, but the information encoded by these transit peptides remains elusive, as they have a high sequence diversity and lack consensus sequences or common sequence motifs. Here, we investigated the sequence information contained in transit peptides. Hierarchical clustering on transit peptides of 208 plastid proteins showed that the transit peptide sequences are grouped to multiple sequence subgroups. We selected representative proteins from seven of these multiple subgroups and confirmed that their transit peptide sequences are highly dissimilar. Protein import experiments revealed that each protein contained transit peptide-specific sequence motifs critical for protein import into chloroplasts. Bioinformatics analysis identified sequence motifs that were conserved among members of the identified subgroups. The sequence motifs identified by the two independent approaches were nearly identical or significantly overlapped. Furthermore, the accuracy of predicting a chloroplast protein was greatly increased by grouping the transit peptides into multiple sequence subgroups. Based on these data, we propose that the transit peptides are composed of multiple sequence subgroups that contain distinctive sequence motifs for chloroplast targeting.
Teprotumumab and Hyperglycemia Guidelines to Monitor for Hyperglycemia in Teprotumumab (2021)

Lee, H. B. Harold M.D.; Mariash, Cary N. M.D.; Yoon, Michael K. M.D.; Belinsky, Irina M.D.; Creighton, Francis X. Jr M.D.; Mahoney, Nicholas M.D.; Petris, Carisa K. M.D.; Callahan, Alison B. M.D.; Campbell, Ashley A. M.D.; Kazim, Michael M.D.; Dagi Glass, Lora R. M.D. Author Information
Hollow-core microstructured polymer optical fiber (2006)

We have fabricated microstructured polymer optical fibers that guide light in a hollow core using the photonic bandgap mechanism. The hollow core allows the use of polymer fibers to be extended to wavelength ranges where material absorption typically prohibits their use, with attenuation lower than the material loss observed in the infrared. The fabrication method is similar to other microstructured polymer optical fibers, which has favorable implications for the feasibility of manufacturing such bandgap fibers.
Synthesis, characterization and catalytic performances of Cu- and Mn-containing ordered mesoporous carbons for the selective catalytic reduction of NO with NH<sub>3</sub> (2014)

The synergetic catalytic effect of Cu and Mn for CuxMny-OMCs catalysts on NO conversion with NH<sub>3</sub>.
The immune response to hepatitis B vaccine in humans: inheritance patterns in families. (1992)

We have recently shown that the human antibody response to the hepatitis B virus surface antigen (HBsAg) vaccine is major histocompatibility complex (MHC) associated. In studies of nonresponders to the vaccine, we found an increased incidence of individuals homozygous for human histocompatibility leukocyte antigen (HLA) proteins associated with the extended (conserved) haplotype [HLA-B8,SC01,DR3]. In later prospective vaccination trials, we showed that none of five individuals homozygous for this haplotype developed more than 1,300 radioimmunoassay (RIA) units of antibody (mean, 467 RIA units), while all heterozygotes made at least 2,500 RIA units (mean antibody level, 15,608 units). Our results suggested that [HLA-B8,SC01,DR3] lacks an immune response gene for HBsAg, and that response is inherited in a dominant fashion. To provide further evidence for this hypothesis, we have now analyzed the results of HBsAg immunization in families. 43 members of 10 families were immunized with the hepatitis B vaccine, including seven families where at least one member bore the haplotype [HLA-B8,SC01,DR3], and three families where one member had already received, but failed to respond to, the vaccine. In two of these three families, the presence of [HLA-B8,SC01,DR3] was subsequently found. Of nine MHC-identical sibling pairs in the study, both members of eight pairs had similar antibody responses (five nonresponder and three responder pairs). In all families with such sibling pairs, including the discordant pair, rank-ordering members by antibody level demonstrated that no relative's value came between the sibling pair values. Furthermore, of nine [HLA-B8,SC01,DR3]-haplotype-homozygous individuals, six were nonresponders, and two others had only low-normal responses. [HLA-B8,SC01,DR3]-heterozygous family members always had higher levels of antibody than their homozygous relatives. Linkage analysis of nonresponse to HLA haplotypes revealed a maximum likelihood LOD (logarithm of the odds) score of 6.3 at a recombination fraction of 0.1. The MHC association with lack of antibody response to HBsAg was not seen with tetanus immunization, where 1 of 20 HBsAg responders and 1 of 21 poor or nonresponders had tetanus titers of less than 1:512; both tetanus nonresponders were [HLA-B8,SC01,DR3] heterozygotes. Our results indicate that: (a) response to the HBsAg vaccine is MHC linked, and inherited in a dominant fashion; (b) an abnormal or missing immune response (Ir) gene for HBsAg is a characteristic of most examples of the extended haplotype [HLA-B8,SC01,DR3]; and (c) other haplotypes also have abnormal or missing Ir genes for HBsAg.
Aportaciones a la nomenclatura de dos variedades linneanas de Myrtus communis (Myrtaceae) (2016)

espanolSe discute la lectotipificacion de los nombres linneanos Myrtus communis var. baetica y var. tarentina (Myrtaceae). La designacion de los tipos nomenclaturales se basa en la consulta del material original de Linneo y la literatura citada en sus respectivos protologos. Ambos nombres son lectotipificados usando especimenes del Herbario de Clifford, conservados en el Museo de Historia Natural de Londres (BM). Se propone un cambio de rango para Myrtus communis var. baetica, considerando el rango de subespecie. EnglishThe lectotypification of the Linnaean names Myrtus communis var. baetica and var. tarentina (Myrtaceae) is discussed. The designation of the nomenclatural types is based on the Linnaeus’s original material and literature cited in the protologue. Both names are lectotypified using specimens at the Herbarium Clifford, preserved in the Natural History Museum of London (BM). A change of range is proposed for Myrtus communis var. baetica, considering the range of subspecies.
The Role of Ceramide Trihexoside (Globotriaosylceramide) in the Diagnosis and Follow-Up of the Efficacy of Treatment of Fabry Disease: A Review of the Literature (2006)

Fabry disease is caused by a deficiency of a-galactosidase A which leads to the progressive intra-lysosomal accumulation of ceramide trihexoside (CTH), also known as globotriaosylceramide (Gb3), in different cell types and body fluids. The clinical manifestations are multisystemic and predominantly affect the heart, kidney and central nervous system. The role of CTH in the pathophysiological process of Fabry disease is not established, and the link between the degree of accumulation and disease manifestations is not systematic. The use of CTH as a diagnostic tool has been proposed for several decades. The recent introduction of a specific treatment for Fabry disease in the form of enzyme replacement therapy (ERT) has led to the need for a biological marker, in place of a clinical sign, for evaluating the efficacy of treatment and also as a tool for following the long term effects of treatment. The ideal biomarker must adhere to strict criteria, and there should be a correlation between the degree of clinical efficacy of treatment and a change in its concentration. This review of the literature assesses the utility of CTH as a diagnostic tool and as a marker of the efficacy of ERT in patients with Fabry disease. Several techniques have been developed for measuring CTH; the principles and the sensitivity thresholds of these methods and the units used to express the results should be taken into consideration when interpreting data. The use of CTH measurement in Fabry disease should be re-evaluated in light of recent published data.
Asymmetric energy coupling through acoustoelectric effect using graphene on lithium niobite surface acoustic wave delay line in GHz Range (2019)

Technology advances provide new processes for the fabrication and application of novel materials to acoustoelectric devices. An important advancement would be the ability to produce practical integrated SAW AE amplifiers. Notably for practical applications, devices will need to be capable of operating with a continuous drift field applied rather than the most often-cited timed pulse approach and be cheaply manufacturable. With ultra-high mobility materials, such as graphene, power reduction can be achieved with the asymmetrical AE effect under a constant applied drift field. This paper will present a new embodiment of a graphene-based AE structure on LiNbO3. The first part of the paper will discuss the theory behind the SAW AE amplifier, including the critical film parameters for the maximum gain. The second part will present a new design and results from recent research efforts to conform graphene to have more ideal thin film parameters for the AE effect.
Trifluoperazine inhibits phagocytosis in a macrophagelike cultured cell line. (1981)

Trifluoperazine, a drug that binds to Ca2+-calmodulin and inhibits its interaction with other proteins, was found to inhibit growth and phagocytosis in a macrophagelike cell line, J774.16. Both effects were reversible and occurred at the same concentrations of drug (25--50 microM) that inhibited the activation of cyclic nucleotide phosphodiesterase by calmodulin in vitro. Fc-mediated phagocytosis was also depressed by W-7, a sulfonamide derivative that inhibits the activity of Ca2+-calmodulin. In contrast, taxol, a drug that stabilizes cellular microtubules, had no effect on Fc-mediated phagocytosis although it inhibited cell growth at nanomolar concentrations. The inhibitory effects of trifluoperazine and W-7 on phagocytosis suggest that calmodulin may be involved in this complex cellular function.
Vertical transmission of human immunodeficiency virus is correlated with the absence of high-affinity/avidity maternal antibodies to the gp120 principal neutralizing domain. (1990)

Many, but not all, infants born to mothers infected with the human immunodeficiency virus (HIV) are infected in utero. We have now shown that mothers who have high-affinity/avidity antibodies directed toward the principal neutralizing domain (PND) of gp120 are less likely to transmit HIV to their children. An ELISA that preferentially measures the level of the biologically functioning, high-affinity/avidity antibodies against PND is described. In a retrospective study of 15 maternal/neonatal serum samples, the assay correctly identified the 4 uninfected and the 11 HIV-infected infants. Other clinical and laboratory parameters such as p24 antigen, phytohemagglutinin mitogenic index, and absolute surface antigen T4+ cell counts did not accurately predict HIV fetal transmission. In addition to introducing a promising diagnostic tool, this study provides the in vivo evidence that protective antibodies may prevent infection by HIV.
Entry and survival of<i>Salmonella typhimurium</i>in dendritic cells and presentation of recombinant antigens do not require macrophage-specific virulence factors (2000)

Macrophages have long been regarded as the main target encountered by Salmonella typhimurium, a Gram-negative facultative intracellular pathogen that invades the intestinal mucosa. S. typhimurium, however, are first internalized by dendritic cells. To gain new insights into the interactions between Salmonella and the dendritic cells, we compared the fate of wild-type S. typhimurium and the virulence-attenuated PhoP constitutive (PhoP(c)) strain. The PhoP(c) strain is impaired for entry and survival in mammalian cells and is poorly processed by macrophages for antigen presentation on MHC class II molecules. Here, we show that bone marrow-derived dendritic cells can similarly process and present a foreign antigen expressed by the invasive wild-type and the attenuated PhoP(c) S. typhimurium. This property correlates with equivalent entry and survival efficiencies of both strains in dendritic cells. In addition, Salmonella strains mutated in mgtCB, sseC, and orfL genes required for macrophage survival showed no defect in survival in dendritic cells. Together, these results indicate that uptake of Salmonella by dendritic cells and subsequent antigen processing and presentation do not depend on virulence factors important in macrophages.
Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis (2020)

The findings of this living systematic review suggest that most people who become infected with SARS-CoV-2 will not remain asymptomatic throughout the course of the infection. The contribution of presymptomatic and asymptomatic infections to overall SARS-CoV-2 transmission means that combination prevention measures, with enhanced hand hygiene, masks, testing tracing, and isolation strategies and social distancing, will continue to be needed.
Development and prospect of coal science and technology in China (2012)

The rapid economic growth relies on a steady energy supply.The benign operation of China's economic puts forward higher requirements to coal industry.The sustained,stable,healthy development of coal industry is inseparable from the progress of science and technology.The development of coal technology at home and abroad is introduced briefly.The main achievements of coal technology used in the fields of coal resources and geological exploration,coal mining,coal processing and utilization,coal-bed gas resources exploitation and utilization,are summarized.Analyze problems with the development of coal science and technology in China.Considering the development target of coal technology formulated in the 12th Five-Year Plan,imagine the future of coal technology development.
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling (2006)

Multiple members of the casein kinase I family of serine/threonine protein kinases are involved in positive and negative roles in Wnt and Hedgehog signaling. Here I review these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of LRP6, and CKI phosphorylation of Ci and mediation of Ci-Slimb/beta-TrCP binding.
I/Q imbalance aware widely-linear channel estimation and detection for uplink massive MIMO systems (2015)

In this paper, we propose an in-phase/quadrature-phase imbalance (IQI) aware widely-linear minimum mean square error (IQA-WLMMSE) receiver for uplink single-cell massive multiple-input multiple-output (MIMO) systems with imperfect channel state information (CSI). In our system model, IQI is present at the base station and user terminals and affects both channel estimation and data detection. The proposed IQA-WLMMSE receiver processes the real and imaginary parts of the received signal separately and mitigates both multiple-access interference (MAI) and IQI. Our analytical and simulation results show that the proposed IQA-WLMMSE receiver performs significantly better than the conventional IQI unaware MMSE (IQU-MMSE) receiver, and its sum rate closely approaches the sum rate of the ideal system with no IQI.
Long wavelength optic phonons in WSe<sub>2</sub> (1977)

The first order Raman spectrum of the layer type semiconducting compound, WSe 2 , has been investigated. The frequencies of the Raman active A 1g , E 2g 1 E 1g , and E 2g 2 modes have been determined to be 253,250, 178, and 25 cm −1 respectively. Using a scaling relation the results have been compared to the values obtained previously for the isostructural compound 2H—MoS 2 . The good agreement that is obtained between the measured and calculated values is taken as corroboration of the present assignments in WSe 2 .
A control flow obfuscation method to discourage malicious tampering of software codes (2006)

The paper presents a control flow obfuscation method to discourage reverse engineering and malicious tampering of software codes. Given the original source codes and desired obfuscation criteria, the proposed method works by decomposing the source codes into fragments and then applying various transforms to the code fragments. As the output of our method, the transformed fragments are re-assembled and obfuscated with the designated obfuscation criteria. Moreover, since only control flows are obfuscated with a sequence of transformations that produce equivalent results of the original fragments, the final output can still preserve the same execution results as the original codes. The proposed method can be combined with other security technologies like watermarking or fingerprinting and thus help discouraging software piracy by making watermarked information embedded in software codes difficult to be reverse engineered or tampered.
BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN: CLINICAL DEVELOPMENT AND POTENTIAL PEDIATRIC APPLICATIONS (2001)

Children’s Medical Center of Dallas and The University of Texas Southwestern Medical Center, Dallas, TX
Dependence of Photosensitive Effect on the Defects Created by DC Stress for LTPS TFTs (2008)

In this letter, the photosensitive effect of n-type low-temperature polycrystalline silicon (LTPS) thin-film transistors (TFTs) after DC stress was investigated. It was discovered that the photo-generated carrier behaviors under optical illumination are related to defect types created by different stress conditions of hot-carrier effect and self-heating effect. These two types of defect creation result in the different photosensitivity behaviors of LTPS TFT. A model considering the relation between photosensitivity and defect is proposed to explain the anomalous illumination behaviors after device degradation.
Near real-time face detection and recognition using a wireless camera network (2012)

We present a portable wireless multi-camera network based system that quickly recognizes face of human subjects. The system uses low-power embedded cameras to acquire video frames of subjects in an uncontrolled environment and opportunistically extracts frontal face images in real time. The extracted images may have heavy motion blur, small resolution and large pose variability. A quality based selection process is first employed to discard some of the images that are not suitable for recognition. Then, the face images are geometrically normalized according to a pool of four standard resolutions, by using coordinates of detected eyes. The images are transmitted to a fusion center which has a multi-resolution templates gallery set. An optimized double-stage recognition algorithm based on Gabor filters and simplified Weber local descriptor is implemented to extract features from normalized probe face images. At the fusion center the comparison between gallery images and probe images acquired by a wireless network of seven embedded cameras is performed. A score fusion strategy is adopted to produce a single matching score. The performance of the proposed algorithm is compared to the commercial face recognition engine Faceit G8 by L1 and other well known methods based on local descriptors. The experiments show that the overall system is able to provide similar or better recognition performance of the commercial engine with a shorter computational time, especially with low resolution face images. In conclusion, the designed system is able to detect and recognize individuals in near real time.
Sign backpropagation: An on-chip learning algorithm for analog RRAM neuromorphic computing systems (2018)

Currently, powerful deep learning models usually require significant resources in the form of processors and memory, which leads to very high energy consumption. The emerging resistive random access memory (RRAM) has shown great potential for constructing a scalable and energy-efficient neural network. However, it is hard to port a high-precision neural network from conventional digital CMOS hardware systems to analog RRAM systems owing to the variability of RRAM devices. A suitable on-chip learning algorithm should be developed to retrain or improve the performance of the neural network. In addition, determining how to integrate the periphery digital computations and analog RRAM crossbar is still a challenge. Here, we propose an on-chip learning algorithm, named sign backpropagation (SBP), for RRAM-based multilayer perceptron (MLP) with binary interfaces (0, 1) in forward process and 2-bit (±1, 0) in backward process. The simulation results show that the proposed method and architecture can achieve a comparable classification accuracy with MLP on MNIST dataset, meanwhile it can save area and energy cost by the calculation and storing of the intermediate results and take advantages of the RRAM crossbar potential in neuromorphic computing.
Nuclear rockets: High-performance propulsion for Mars (1994)

A new impetus to manned Mars exploration was introduced by President Bush in his Space Exploration Initiative. This has led, in turn, to a renewed interest in high-thrust nuclear thermal rocket propulsion (NTP). The purpose of this report is to give a brief tutorial introduction to NTP and provide a basic understanding of some of the technical issues in the realization of an operational NTP engine. Fundamental physical principles are outlined from which a variety of qualitative advantages of NTP over chemical propulsion systems derive, and quantitative performance comparisons are presented for illustrative Mars missions. Key technologies are described for a representative solid-core heat-exchanger class of engine, based on the extensive development work in the Rover and NERVA nuclear rocket programs (1955 to 1973). The most driving technology, fuel development, is discussed in some detail for these systems. Essential highlights are presented for the 19 full-scale reactor and engine tests performed in these programs. On the basis of these tests, the practicality of graphite-based nuclear rocket engines was established. Finally, several higher-performance advanced concepts are discussed. These have received considerable attention, but have not, as yet, developed enough credibility to receive large-scale development.
Molecular order in polymerizable Langmuir-Blodgett films probed by microfluorescence and scanning force microscopy (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular order in polymerizable Langmuir-Blodgett films probed by microfluorescence and scanning force microscopyBarbara M. Goettgens, Ralf W. Tillmann, Manfred Radmacher, and Hermann E. GaubCite this: Langmuir 1992, 8, 7, 1768–1774Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/la00043a014https://doi.org/10.1021/la00043a014research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts