gebhart/patrepeval huggingface dataset:
Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. (1993)

Tamoxifen, a nonsteroidal antiestrogen used widely in the treatment of breast cancer, was tested in a conventional 2-year carcinogenicity bioassay in rats, a species in which tamoxifen acts variably as a partial agonist and antagonist on different target tissues. Groups of 51 males and 52 females were given 5, 20, and 35 mg/kg of tamoxifen/day by gastric intubation in 0.5% hydroxypropyl methylcellulose at 5 ml/kg dose volume. There were 102 male and 104 female controls dosed with vehicle alone. Growth rate and food consumption were reduced in all treated groups. The major finding was a dose-related increase in the incidence of hepatocellular tumors which were first observed after 31 weeks of treatment in the top dose group. The majority of the neoplasms were hepatocellular carcinomas showing a well differentiated trabecular pattern. Some tumors were glandular in type. Mortality was increased in the 20 and 35 mg/kg dose groups compared with controls as a result of these tumors. By contrast, survival was greater than controls in rats given 5 mg/kg tamoxifen despite the presence of hepatocellular tumors due to a reduction in the number of pituitary tumors in females and less chronic renal disease in males. The mechanism of hepatic tumor induction by tamoxifen in rats is unclear. In view of the lack of genotoxic activity in conventional genotoxicity studies and lack of similar effect in mice or in humans, the findings may relate to a particular constellation of effects in rats. All other drug-induced changes in this study were nonneoplastic in nature and most appeared to be the result of hormonal perturbation since they were confined to endocrine organs or have been seen previously in rats treated for long periods with tamoxifen.
Helios but not CD226, TIGIT and Foxp3 is a Potential Marker for CD4+ Treg Cells in Patients with Rheumatoid Arthritis (2019)

Taken together, our findings indicate that CD4<sup>+</sup>CD25<sup>hi</sup>CD127<sup>low/-</sup>Foxp3<sup>+</sup>Helios<sup>+</sup> may represent the real Treg cell population in patients with RA.
A Joint Control–Communication Design for Reliable Vehicle Platooning in Hybrid Traffic (2017)

Recent studies have shown that traffic safety and efficiency can be substantially improved by vehicle platooning, in which vehicles periodically broadcast their kinetic status to neighbors, known as beacon message dissemination. As a networked control system, vehicle platoon has attracted significant attention from both the control and networking areas. However, few studies consider the practical traffic scenario with both platoons and individual vehicles, and the proposed beaconing schemes lack the deep understanding of relationship between the beaconing performance and the requirements of the control mechanism. To address these challenging issues, we propose a joint control-communication design to achieve reliable vehicle platooning in a more realistic traffic scenario, wherein the traffic consists of both platoons and individual vehicles, and both periodic beacon messages and event-based safety messages shall be delivered together. Specifically, we first develop a comprehensive control-theoretical analysis to understand how the vehicular communication can affect features of platoon driving; based on the understanding, we then propose and analyze an adaptive platoon-based message dissemination scheme; finally, we conduct extensive numerical experiments to validate the effectiveness of the protocol and to confirm the accuracy of the our theoretical analysis.
Ray tracing with amalgams (1991)

Traditional ray tracing databases that use bounding volumes attach only geometric properties (e.g. position, orientation, size) to each bounding volume. By also associating shading properties (e.g. color, translucency, reflectance) with each bounding volume, the database can become a multi-resolution database--a database that represents objects at different levels of detail. Specifically, the bounding region itself may be rendered to coarsely represent the objects inside it. With a minor extension to the traditional ray tracing algorithm, a ray tracing renderer can traverse such a database with fewer intersection tests per ray, improved antialiasing, and (arguably) better asymptotic time complexity. The enhanced database and algorithm are particularly suited to scenes containing a large number of primitives at a wide range of scales.
Near-infrared spectroscopy monitoring of cerebral oxygen during assisted ventilation (2011)

The results of the study demonstrate the utility of NIRS to accurately reflect changes in cerebral oxygenation and flow to the brain in response to changes in CO(2) levels in anesthetized, ventilated neonatal piglets. The use of NIRS may provide an early alert of low levels of cerebral blood flow and brain oxygenation, potentially helping in preventing the progression of IVH or PVL in the neonate.
Inhibition of blood clearance and hepatic tissue binding of Escherichia coli by liver lectin-specific sugars and glycoproteins (1984)

The effects of sugars and glycoproteins that are known to bind to lectins of liver tissue on the clearance of cells of Escherichia coli from mouse blood was investigated. The administration of 100 mg per mouse of methyl-alpha-D-mannoside, methyl-alpha-D-glucoside, or methyl-alpha-D-fucoside, but not of methyl-alpha-D-galactoside or L-rhamnose, markedly inhibited the blood clearance of cells of E. coli 346. Clearance was similarly inhibited by 0.1 and 1.0 mg per mouse of asialofetuin or ovalbumin, respectively, whereas fetuin had no effect. The inhibitory effects of the sugars on blood clearance was abolished by pretreating the E. coli cells with antibodies against whole organisms. All of these effects were equal for fimbriated and nonfimbriated phenotypes of E. coli 346. Homogenates of mouse liver tissue coaggregated with nonfimbriated cells of E. coli. The aggregation was blocked by 100 mM solutions of methyl-alpha-D-mannoside, or methyl-alpha-D-glucoside, 1 mg of bacterial lipopolysaccharide per ml, or 10 mM EDTA but not by L-rhamnose. These results suggest that the mannose-N-acetylglucosamine hepatic lectin recognizes specific sugars on the surface of E. coli and may be centrally involved in the nonimmune clearance of nonfimbriated E. coli from the blood of the infected host.
Heparin-like synthetic polymers, named RGTAs, mimic biological effects of heparin in vitro. (2006)

A family of biopolymers engineered to protect and stabilize heparin binding growth factors (HBGFs) show remarkable properties as wound healing agents in several in vivo tissue repair models to the extend that damaged tissues would recover almost its initial aspect and properties. These polymers where named RGTA for regenerating agents and proposed to act in vivo by enhancing the bioavailability of HBGFs at the site of the injury. To provide support for this hypothesis, we studied interaction of RGTA with FGF-2, taken as the paradigm of HBGFs, and its high- and low-affinity receptors as well as its ability to inhibit heparanase activity. We show that RGTA is comparable to heparin as it favors FGF-2 binding to FGFR-1 and FGF-2 dimerization and potentiates FGF-2-induced mitogenic activity. Furthermore, we show that RGTA inhibits the release of FGF-2 from its extracellular matrix storage sites by heparanase. Our data provide new evidence to support that RGTA may act in vivo both by enhancing HBGF activity and preserving HBGF availability by protecting the matrix low affinity heparan sulfates from rapid heparanase degradation
Regulation of transgene expression in sugarcane (1999)

Plantaricin BM-1 is a class IIa bacteriocin with a strong bactericidal effect on gram-positive bacteria. Although plantaricin BM-1 also inhibits the growth of some gram-negative bacteria, including Escherichia coli, the mechanism is not clear. In this study, we used tandem mass tag-based quantitative proteomics analysis to examine the inhibitory mechanism of plantaricin BM-1 against E. coli K12, and evaluated the morphological effects by electron microscopy. The results demonstrated that plantaricin BM-1 inhibits the growth of E. coli K12 by bacteriostatic action, mainly acting on the surface of the cell wall, leading to its collapse. Proteomic analysis identified 976 differentially expressed proteins (>1.2-fold change, p < 0.05) under treatment with plantaricin BM-1, including 490 up-regulated proteins and 486 down-regulated proteins. These proteins were mainly involved in peptidoglycan synthesis and energy metabolism pathways, including amino acid, glyoxylate and dicarboxylate, ABC transporter, and quorum-sensing pathways. Specifically, plantaricin BM-1 treatment significantly improved peptidoglycan synthesis and enhanced the tricarboxylic acid cycle in E. coli K12, and altered the expression of cell membrane proteins. These results provide new insight into the inhibition mechanism of class IIa bacteriocins on gram-negative bacteria, which can lay the foundation for its broader use as an alternative to conventional antibiotics.
Stereo Image Matching for Vehicle-Borne Mobile Mapping System Based on Digital Parallax Model (2011)

Considering automatic and effective stereo image matching for vehicle-borne mobile mapping system (VMMS), a new stereo image matching algorithm based on digital parallax model (DPM) is proposed in this paper. The new matching propagation strategy is designed in this algorithm, which includes two processes as DPM construction and parallax prediction. With some known matched points, the DPM of stereo image pairs is firstly constructed, and parameters for confirming conjugate epipolar line is also worked out. Then searching range during dense matching can be confirmed under constraints of DPM and epipolar line, which can improve matching speed and accuracy. Furthermore, to improve matching robustness, the computation model of similarity measurement combined with local structure feature and global color feature is designed. The new algorithm is applied to actual stereo images taken by VMMS to verify its validity. Experimental results show that the proposed approach has higher reliability and accuracy.
A Wireless Sensor Network Ad-Hoc Designed as Anti-Theft Alarm System for Photovoltaic Panels (2012)

Photovoltaic (PV) systems have attracted increasing attention in last years as well as Wireless Sensor Networks (WSNs), which have been used in many application fields. In PV plants, especially in ground installations, a lot of thefts and damages occur due to the still high cost of the modules. A new experimental WSN ad-hoc has been designed to be an anti-theft alarm system. Each node of the network is directly installed under each PV string and it is equipped with an accelerometer sensor capable to detect a minimum displacement of the panel from its steady position. The WSN presents a star topology: a master node cyclically interrogates the slave nodes through RF link. It collects all the nodes responses and communicates though a RS-232 interface with a control PC checking the network status. When a slave node detects an alarm, continuous messages are sent to the control PC which turns on all the alarm signaling systems. The control PC is equipped with an open source operative system and software and provides for SMS, e-mail and sound-light signaling in case of alarm. It also communicates with a remote server where all the WSN information is stored. A first low cost experimental WSN has been already installed and it is working properly.
Power System for 21st Century Fighter Aircraft (1989)

<div class="htmlview paragraph">To increase crew and aircraft survivability for 21st century fighters, a power system is envisioned which can supply higher power at high altitudes at the touch of a button. In the event of an aircraft power outage, this emergency power would be used to get the aircraft back under control and to restart the propulsion engines. The heart of the power system is a gas turbine, an Integrated Power Unit (IPU), designed to meet these requirements by starting and supplying 200 horsepower in two seconds, using a stored oxidizer (from air storage tanks on board the aircraft). The compressor is “aerodynamically declutched” in this emergency power mode, minimizing the stored air needed by the IPU to supply the required power. In addition, the IPU can smoothly transition over to the normal air breathing mode, where the compressor supplies full flow and the stored air is not used at all. The size of the stored oxidizer supply is critical to establishing viability of this type of aircraft power system. This paper presents the results of the air bottle sizing study and concludes that a power system with reduced complexity, via the IPU concept, can significantly increase reliability, and reduce life cycle cost, at equivalent weight when compared to the latest power systems.</div>
Marlowe’s Literary Double Agency: <i>Doctor Faustus</i> as a Subversive Comedy of Error (2000)

Le présent article se veut une réévaluation des éléments comiques du 1616 (“B”) texte de Doctor Faustus deMarlowe, lesquels ont été régulièrement sous-estimés ou trop hâtivement catégorisés comme frivoles, falsifiés, ou nuisibles à l’unité de la pièce. Au lieu de les intégrer dans la tradition homilétique, donc celle du théâtre moralisateur du Moyen Âge, cette étude les trouve parodiques et subversifs. Le traitement de Marlowe annonce une nouvelle sensibilité littéraire d’indéterminisme ludique et ambiguïté morale.
Automatic Tracking of Moving Objects in Video for Surveillance Applications (2007)

Automated surveillance systems are of critical importance for the field of security. The task of reliably detecting and tracking moving objects in surveillance video, which forms a basis for higher level intelligence applications, has many open questions. Our work focuses on developing a framework to detect moving objects and generate reliable tracks from real-world surveillance video. After setting up a basic system that can serve as a platform for further automatic tracking research, we tackle the question of variation in distances between the camera and the objects in different parts of the scene (object depth) in surveillance videos. A feedback-based solution to automatically learn the distance variation in staticcamera video scenes is implemented, based on object motion in different parts of the scene. The solution, based on a concept that we call ’Vicinity Factor’, is robust to noise and object segmentation problems. The Vicinity Factor can also be applied to estimate spatial thresholds and object size in different parts of the scene. Further, a new Bayesian algorithm to assign tracks to objects in the video is developed. The Bayesian method allows for probabilistic track assignment and can be the basis for future higher-level inference.
Input Test Data Volume Reduction for Skewed-Load Tests by Additional Shifting of Scan-In States (2014)

Test data compression methods reduce the input test data volume by allowing compressed tests to be stored on a tester. Additional reductions in the input test data volume can be achieved if each stored test is used for producing several different tests. Skewed-load tests create a unique opportunity to expand a stored test into several different skewed-load tests by continuing to shift the scan-in state for one or more additional clock cycles. This opportunity for test data volume reduction beyond test data compression is introduced in this paper. The paper describes a procedure that starts from a given skewed-load test set. The procedure removes tests from the test set and recovers the fault coverage by applying several tests based on every stored test.
Low molecular weight complexes of zinc and other trace metals in lettuce leaf (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow molecular weight complexes of zinc and other trace metals in lettuce leafColin D. Walker and Ross M. WelchCite this: J. Agric. Food Chem. 1987, 35, 5, 721–727Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://doi.org/10.1021/jf00077a020RIGHTS & PERMISSIONSArticle Views131Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Do cytogenetic abnormalities precede morphologic abnormalities in a developing malignant condition? (2006)

Cytogenetic evaluation of bone marrow and neoplastic tissues plays a critical role in determining patient management and prognosis. Here, we highlight two cases in which the cytogenetic studies challenge the common practice of using hematologic and morphologic changes as key factors in malignant disease management. The first case is that of a lymph node sample from a 40-yr-old non-Hodgkin's lymphoma (NHL) patient sent for determination of disease progress. Hematologic studies showed no evidence of transformation to high-grade NHL (>15% blasts with rare mitotic figures). Cytogenetic studies of lymph node showed multiple clonal abnormalities, most notably a der(18) from a t(14;18) which is associated with high-grade NHL. After two cycles of chemotherapy with fludarabine, the patient did not show any clinical response, suggesting possible progression to high-grade lymphoma. The second case is of a patient with a history of human immunodeficiency virus and blastic natural killer leukemia/lymphoma. Hematologic studies of ascitic fluid classified the patient as having pleural effusion lymphoma whereas bone marrow analysis showed no malignancy. Bone marrow cytogenetic studies showed multiple clonal abnormalities including a t(8;14), which is commonly associated with Burkitt's lymphoma (BL). To our knowledge, this is the first case wherein a morphologically normal bone marrow showed presence of clonal abnormalities consistent with BL or Pleural effusion lymphoma. After two cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy, the patient's general condition and ascitis improved and she was discharged. These studies clearly demonstrate that genetic changes often precede morphologic changes in a developing malignant condition. Therefore, the critical information needed for care of patients with malignant disorders may be incomplete or inaccurate if cytogenetic evaluation is overlooked.
Permeability Effects of Two Dentin Adhesive Systems (1992)

This in vitro study evaluated the effects of two dentin adhesive systems on dentin permeability. The XR‐Bonding System modifies the smear layer but does not open dentinal tubules. The Kanca or “total‐etch” technique (phosphoric acid, Tenure A and B, Scotchbond 2 Adhesive) removes the smear layer and opens dentinal tubules. Despite these differences, both systems reduced dentin permeability in a similar manner. XR‐Bond decreased permeability to 52% of the smear layer value, while total etching reduced permeability to 66% of that value.
Protective humoral response against pneumococcal infection in mice elicited by recombinant bacille Calmette-Guérin vaccines expressing pneumococcal surface protein A. (1994)

Pneumococcal surface protein A (PspA), a cell-surface protein present on all strains of pneumococci, has been shown to elicit protective antibody responses in mice in the absence of capsular polysaccharide. Whereas PspA is polymorphic, considerable cross-reactivity and cross-protection have been demonstrated among PspA proteins of pneumococci exhibiting different capsular and PspA serotypes. A gene segment encoding the nonrepetitive variable NH2-terminal portion of PspA has been cloned into three distinct recombinant Bacille Calmette-Guérin (rBCG) vectors, allowing for expression of PspA as a cytoplasmic or secreted protein, or a chimeric exported membrane-associated lipoprotein. All rBCG-PspA strains elicited comparable anti-PspA ELISA titers, ranging from 10(4) to 10(5) (reciprocal titers) in both BALB/c and C3H/HeJ mice. However, protective responses were observed only in animals immunized with the rBCG-PspA vaccines expressing PspA as a secreted protein or chimeric exported lipoprotein. In addition, anti-PspA immune sera elicited by the rBCG vaccines passively protected X-linked immunodeficient mice from lethal challenge with the highly virulent, encapsulated WU2 strain of Streptococcus pneumoniae and two additional virulent strains exhibiting heterologous PspA and capsular serotypes. These studies confirm previous PspA immunization studies showing cross-protection against heterologous serotypes of S. pneumoniae and demonstrate a potential for rBCG-based PspA vaccines to elicit protective humoral responses against pneumococcal disease in humans.
Crop yield prediction using machine learning: A systematic literature review (2020)

Machine learning is an important decision support tool for crop yield prediction, including supporting decisions on what crops to grow and what to do during the growing season of the crops. Several machine learning algorithms have been applied to support crop yield prediction research. In this study, we performed a Systematic Literature Review (SLR) to extract and synthesize the algorithms and features that have been used in crop yield prediction studies. Based on our search criteria, we retrieved 567 relevant studies from six electronic databases, of which we have selected 50 studies for further analysis using inclusion and exclusion criteria. We investigated these selected studies carefully, analyzed the methods and features used, and provided suggestions for further research. According to our analysis, the most used features are temperature, rainfall, and soil type, and the most applied algorithm is Artificial Neural Networks in these models. After this observation based on the analysis of machine learning-based 50 papers, we performed an additional search in electronic databases to identify deep learning-based studies, reached 30 deep learning-based papers, and extracted the applied deep learning algorithms. According to this additional analysis, Convolutional Neural Networks (CNN) is the most widely used deep learning algorithm in these studies, and the other widely used deep learning algorithms are Long-Short Term Memory (LSTM) and Deep Neural Networks (DNN).
Time-gated x-ray tomography (1998)

Time-gated x-ray tomography with scatter reduction is demonstrated using a laser-produced plasma as an ultrashort-pulse x-ray source in combination with a time-resolving streak-camera detector. Backprojections of a phantom imbedded in 9 cm of water show an effective 50% increase in contrast when scattered x-ray quanta (being delayed in time) are suppressed by gating on the prompt, nonscattered photons. Implications for future volumetric tomography, in particular concerning possible dose reductions, are discussed.
One Type of Oxide Cathode for HIRFL-CSR Electron Cooler (2011)

摘要: 该文主要研制一种用于HIRFL-CSR电子冷却装置的氧化物阴极，测试了该阴极在普通试验二极管中的发射性能及寿命，研究了成型阴极表面温度均匀性及其分解激活过程。结果表明，阴极支取直流发射电流密度0.5 A/cm2，工作温度750℃～800℃时具有很好的发射均匀性，电流加速寿命结果表明，该阴极在800℃，寿命超过18000 h。 关键词: 氧化物阴极 / 电子冷却 / 发射性能 / 寿命