gebhart/patrepeval huggingface dataset:
Acceleration compensation for biped robots to reject external disturbances (1989)

The disturbance rejection problem associated with practical biped robots is studied. When the biped robot receives an external disturbance, robot joints suffer abrupt velocity changes. This causes angular velocity of the supporting angle (the angle between the supporting foot and ground) to deviate from 0 degrees , which makes the robot unstable. To reject external disturbances, a strategy called acceleration compensation is proposed. This strategy uses joint accelerations to impose negative acceleration on the angular velocity of the supporting angle, i.e the acceleration is in the opposite direction to the angular velocity. The angular velocity acquired at the moment of a disturbance can thus be reduced to zero in a minimum amount of time, so the deviation of the supporting angle is minimized. Computer simulation and experimental results are presented that verify the usefulness of the method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modified glycosylation of cellobiohydrolase I from a high cellulase‐producing mutant strain of <i>Trichoderma reesei</i> (1998)

Cellobiohydrolase I is an industrially important exocellulase secreted in high yields by the filamentous fungus Trichoderma reesei. The nature and effect of glycosylation of CBHI and other cellulolytic enzymes is largely unknown, although many other structural and mechanistic aspects of cellulolytic enzymes are well characterised. Using a combination of liquid chromatography, electrospray mass spectrometry, solid-phase Edman degradation, and monosaccharide analysis we have identified every site of glycosylation of CBHI from a high cellulase-producing mutant strain of T. reesei, ALKO2877, and characterised each site in terms of its modifying carbohydrate and site-specific heterogeneity. The catalytic core domain comprises three N-linked glycans which each consist of a single N-acetylglucosamine residue. Within the glycopeptide linker domain, all eight threonines are variably glycosylated with between at least one, and up to three, mannose residues per site. All serines in this domain are at least partially glycosylated with a single mannose residue. This linker region has also been shown to be sulfated by a combination of ion chromatography and collision-induced dissociation electrospray mass spectrometry. The sulfate is probably mannose-linked. The biological significance of N-linked single N-acetylglucosamine in the catalytic core, and mannose sulfation in the linker region, is not known.
A Direct Power Injection Model for Immunity Prediction in Integrated Circuits (2008)

This paper introduces a complete simulation model of a direct power injection (DPI) setup, used to measure the immunity of integrated circuits to conducted continuous-wave interference. This model encompasses the whole measurement setup itself as well as the integrated circuit under test and its environment (printed circuit board, power supply). Furthermore, power losses are theoretically computed, and the most significant ones are included in the model. Therefore, the injected power level causing a malfunction of an integrated circuit, according to a given criterion, can be identified and predicted at any frequency up to 1 GHz. In addition to that, the relationship between immunity and impedance is illustrated. Simulation results obtained from the model are compared with measurement results, and these demonstrate the validity of this approach.
Wave energy forecasting using artificial neural networks in the Caspian Sea (2013)

Providing energy without unfavourable impact on the environment is an important issue that is considered by societies. This paper focuses on forecasting the wave energy over horizons of 1–12 h, in the southern part of the Caspian Sea. For this purpose, an artificial neural network was used to obtain the wave energy flux using two different methods. First, the components of wave energy flux, including the significant wave height and peak wave period were predicted separately and the wave energy flux was calculated by combining them; and second, the wave energy flux was forecast directly. The results showed that the prediction of components separately yielded more accurate results. It was found that the longer the forecasting time horizon, the less accurate was the prediction. This is because in large time horizons, the previous wave characteristics have little influence on the wave energy flux. The forecast wave energy flux in both methods correlated well with observed data in short horizons.
Automated Optimisation of Simultaneous Multibeam and Sidescan Sonar Seabed Mapping (2007)

With the costs involved in offshore seabed mapping being very large and dominated principally by the expense of survey vessel time, any improvement in the planning and execution of seabed mapping, improvement in the quality of the resulting data, and especially reduction in survey costs are of significant interest to the marine and offshore community. This paper presents a terrain adaptive seabed mapping system, which simultaneously operates co-located high-resolution multibeam and sidescan sonar of similar frequency. The automated system is based on the interleaving of sonar transmission-reception cycles to avoid interference. The proposed system optimises the execution of the seabed mapping survey, improves the quality of the data and reduces survey costs.
Vertical Alignment of Liquid Crystals Over a Functionalized Flexible Substrate (2018)

A simple and effective approach for vertical alignment of liquid crystals (LCs) over a functionalized transparent flexible substrate is described. Surface characterization of this commercially available plastic substrate through X-ray photoelectron spectroscopy (XPS) and attenuated total reflection infrared spectroscopy (ATR-IR) indicated that cellulose acetate is main component of the transparent substrate. This substrate was chemically functionalized with a suitable LC compound. A trimethoxysilane terminated new rod-shaped mesogen is synthesized and covalently attached to the pre-treated film through silane condensation reaction. LC functionalization of the polymer film is confirmed through contact angle (CA), atomic force microscopy (AFM), XPS and ATR-IR spectroscopy studies. Versatility of the LC modified flexible substrates for the alignment of bulk LC sample at substrate-LC interface was assessed for nematic (N) and smectic A (SmA) phases. Remarkably, LC functionalized cellulose acetate films were found to be highly efficient in assisting a perfect homeotropic alignment of LCs (for both, a room temperature N and a high temperature SmA phase) over the entire area of the LC sample under observation indicating their superior aligning ability in comparison to their unmodified and octadecyltrimethoxysilane (OTS) modified counterparts. The demonstrated method of surface modification of flexible polymer film is easy, surface modified substrates are stable for several months, retained their aligning ability intact and more importantly they are reusable with maximum delivery.
Beamspace adaptive beamforming for ultrasound imaging (2009)

Applying the Capon adaptive beamformer in medical ultrasound imaging results in enhanced resolution by improving the interference-suppressing capabilities of the array. This improvement comes at the expense of an increased computational complexity. We have investigated the application of a beamspace adaptive beamformer for medical ultrasound imaging, which can be used to achieve reduced computational complexity with performance comparable to that of the Capon beamformer. The idea behind beamspace beamforming is that, instead of using the spatial statistics of the elements in the array to differentiate between signals and interference, we use the spatial statistics of a set of orthogonal beams, which are formed in different directions. This represents a shift from element space to beamspace. Because the majority of interference in medical ultrasound imaging is constrained to a limited spatial interval due to the focused transmit beam, this latter space can be reduced to a dimension that is lower than that of element space. We show, using simulations and experimental data, that this dimension can be selected as low as 3 while still achieving performance comparable to its element space counterpart.
SceneSkim (2015)

Searching for scenes in movies is a time-consuming but crucial task for film studies scholars, film professionals, and new media artists. In pilot interviews we have found that such users search for a wide variety of clips---e.g., actions, props, dialogue phrases, character performances, locations---and they return to particular scenes they have seen in the past. Today, these users find relevant clips by watching the entire movie, scrubbing the video timeline, or navigating via DVD chapter menus. Increasingly, users can also index films through transcripts---however, dialogue often lacks visual context, character names, and high level event descriptions. We introduce SceneSkim, a tool for searching and browsing movies using synchronized captions, scripts and plot summaries. Our interface integrates information from such sources to allow expressive search at several levels of granularity: Captions provide access to accurate dialogue, scripts describe shot-by-shot actions and settings, and plot summaries contain high-level event descriptions. We propose new algorithms for finding word-level caption to script alignments, parsing text scripts, and aligning plot summaries to scripts. Film studies graduate students evaluating SceneSkim expressed enthusiasm about the usability of the proposed system for their research and teaching.
Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-<i>d</i>]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors (2006)

Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of alkynamide analogues of quinazoline- and pyrido[3,4-d]pyrimidine-based compounds. The compounds were prepared by coupling the appropriate 6-aminoquinazolines or 6-aminopyrido[3,4-d]pyrimidines with alkynoic acids, using EDCI.HCl in pyridine. The compounds showed pan-erbB enzyme inhibition but were on average about 10-fold more potent against erbB1 than against erbB2 and erbB4. For cellular inhibition, the nature of the alkylating side chains was an important determinant, with 5-dialkylamino-2-pentynamide type Michael acceptors providing the highest potency. This is suggested to be due to an improved ability of the amine to participate in an autocatalysis of the Michael reaction with enzyme cysteine residues. Pyrido[3,4-d]pyrimidine analogue 39 was selected for in vivo evaluation and achieved tumor regressions at 10 mg/kg in the A431 human epidermoid carcinoma and at 40 mg/kg for the SF767 human glioblastoma and the SKOV3 human ovarian carcinoma. Complete stasis was observed at 40 mg/kg in the BXPC3 human pancreatic carcinoma as well as in the H125 human non-small-cell lung carcinoma.
Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression. (2011)

The papillomavirus (PV) E2 proteins have been shown to exert many functions in the viral cycle including pivotal roles in transcriptional regulation and in viral DNA replication. Besides these historical roles, which rely on their aptitude to bind to specific DNA sequences, E2 has also been shown to modulate the host cells through direct protein interactions mainly through its amino terminal transactivation domain. We will describe here some of these new functions of E2 and their potential implication in the HPV-induced carcinogenesis. More particularly we will focus on E2-mediated modulation of the host cell cycle and consequences to cell transformation. In all, the HPV E2 proteins exhibit complex functions independent of transcription that can modulate the host cells in concert with the viral vegetative cycle and which could be involved in early carcinogenesis.
Passively modelocked VECSEL emitting 682 fs pulses with 5.1 W of average output power (2012)

A quantum-well vertical-external-cavity surface-emitting laser in combination with a quantum-well SESAM is used to generate femtosecond pulses. The passively modelocked VECSEL operates at room temperature emitting an average output power of 5.1 W at 1030 nm. At a repetition rate of 1.71 GHz, the 682 fs pulses are nearly transform limited.
Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-gamma. (1998)

IFN-gamma is a potent activator of mononuclear phagocyte function and promotes the development of Th1 responses. Moreover, it induces and modulates chemokine production in a variety of cell types, including mononuclear phagocytes. In the present study, we examined the effect of IFN-gamma on the expression of CC chemokine receptors in human monocytes. IFN-gamma selectively and rapidly inhibited expression of the monocyte chemotactic protein (MCP) receptor CCR2 with an ED50 of approximately 50 U/ml. The effect was rapid (detectable after 1 h) and reversible. Other chemokine receptors (CCR1, CCR3, CCR4, and CCR5) were not substantially affected, and CXCR4 was reduced. IFN-gamma acted in concert with LPS, TNF-alpha, and IL-1beta in inhibiting CCR2 expression. IFN-gamma-treated monocytes showed a shorter half-life of CCR2 mRNA compared with untreated cells, whereas the rate of nuclear transcription was unaffected. The inhibition of CCR2 mRNA expression by IFN-gamma was associated with a lower number of surface receptors and lower chemotactic responsiveness. Thus, IFN-gamma, an inducer of MCP-1 and MCP-3 in mononuclear phagocytes, selectively inhibits expression of the MCP receptor CCR2 in monocytes. These results are consistent with an emerging paradigm of divergent regulation by several agents of chemokine production and receptor expression in monocytes. The inhibition of MCP-1R expression may serve as a means of retaining mononuclear phagocytes at sites of inflammation and as a feedback mechanism in the regulation of recruitment from the blood.
A Simple and Efficient Microassay Method for Titration of Interferon (1977)

A simple and efficient microassay method for the titration of interferon was developed by the use of microtest plates for handling a large number of samples. L929 cells pretreated with interferon were infected with vesicular stomatitis virus (VSV) and cultured in the presence of 3H-uridine. The activity was expressed by the reduction of extracellular radioactive RNA released after destruction of the infected cells, which was measured in terms of the radioactivity incorporated into cold TCA-insoluble materials in the culture fluid. The interferon titer determined by this method was in the same order as that by the plaque reduction method. The activity by this method was parallel to, but lower than that expressed by the yield reduction of infectious viruses. This method requires only 0.025 ml of each test sample with higher than 1 NIH ref. unit/ml to detect its interferon activity and takes 2 to 3 days for assaying hundreds of samples.
The effect of cervical grooves on the contraction gap in class 2 composites. (1993)

The extent and the width of the cervical contraction gap in class 2 composite resin restorations were examined using a fluorescent resin-penetrating technique. In all restorations Scotchbond 2 bonding system and P-50 were used. The cervical wall was prepared either with no groove or with one or two grooves. The results indicated that the extent of the contraction gap was reduced when two retention grooves were prepared. The difference between no groove and two grooves was statistically significant. The width of the gap was also reduced, but not with statistical significance. A statistical difference was also found when one retention groove was compared with no groove.
A Stepwise Rate-Compatible LDPC and Parity Management in NAND Flash Memory-Based Storage Devices (2020)

The storage capacity of the NAND flash memory has increased rapidly, and accordingly, the error rate for data writing and reading to the flash memory cell has also escalated. Error-correcting code (ECC) modules, such as low-density parity-check (LDPC), have been applied to flash controllers for error recovery. However, since the error rate increases rapidly, compared to the aging factor and program/erase (P/E) cycle, fixed ECCs and parities are inappropriate methods for resolving this proliferating error, according to the P/E cycle. Therefore, the design of a dynamic ECC scheme and a proper ECC parity management system to increase the lifespan of flash memory storage devices remains in great demand. Herein, an LDPC encoding and decoding scheme is designed to obtain a step-by-step code rate according to the P/E cycle by applying a stepwise rate-compatible LDPC. In addition, an ECC parity management scheme for the increasingly excessive stage-wise ECC is proposed to reduce management and read/write operational overheads. The ECC management scheme also includes the ECC cache system. The proposed LDPC, as well as its management system, will improve the recovery ability of the NAND flash storage device according to the P/E cycle, while it can reduce system read and write overheads due to additional parity data growth.
Sustained Reduction of Vein Graft Neointima Formation by Ex Vivo TIMP-3 Gene Therapy (2011)

Overexpression of TIMP-3 provides a sustained retardation of vein graft intimal thickening and highlights the translational potential for ex vivo TIMP-3 gene therapy.
Sox2 modulates the function of two distinct cell lineages in mouse skin (2013)

In postnatal skin the transcription factor Sox2 is expressed in the dermal papilla (DP) of guard/awl/auchene hair follicles and by mechanosensory Merkel cells in the touch domes of guard hairs. To investigate the consequences of Sox2 ablation in skin we deleted Sox2 in DP cells via Blimp1Cre and in Merkel cells via K14Cre. Loss of Sox2 from the DP did not inhibit hair follicle morphogenesis or establishment of the dermis and hypodermis. However, Sox2 expression in the DP was necessary for postnatal maintenance of awl/auchene hair follicles. Deletion of Sox2 via K14Cre resulted in a decreased number of Merkel cells but had no effect on other epithelial compartments or on the dermis. The reduced number of Merkel cells did not affect the number or patterning of guard hairs, nerve density or the interaction of nerve cells with the touch domes. We conclude that Sox2 is a marker of two distinct lineages in the skin and regulates the number of differentiated cells in the case of the Merkel cell lineage and hair follicle type in the case of the DP.
Genome‐wide identification of tolerance mechanisms toward <i>p</i>‐coumaric acid in <i>Pseudomonas putida</i> (2017)

The soil bacterium Pseudomonas putida KT2440 has gained increasing biotechnological interest due to its ability to tolerate different types of stress. Here, the tolerance of P. putida KT2440 toward eleven toxic chemical compounds was investigated. P. putida was found to be significantly more tolerant toward three of the eleven compounds when compared to Escherichia coli. Increased tolerance was for example found toward p-coumaric acid, an interesting precursor for polymerization with a significant industrial relevance. The tolerance mechanism was therefore investigated using the genome-wide approach, Tn-seq. Libraries containing a large number of miniTn5-Km transposon insertion mutants were grown in the presence and absence of p-coumaric acid, and the enrichment or depletion of mutants was quantified by high-throughput sequencing. Several genes, including the ABC transporter Ttg2ABC and the cytochrome c maturation system (ccm), were identified to play an important role in the tolerance toward p-coumaric acid of this bacterium. Most of the identified genes were involved in membrane stability, suggesting that tolerance toward p-coumaric acid is related to transport and membrane integrity.
Civis evangelii: Educación lasallista y socialización de valores (2017)

Resumen— El presente texto analiza la huella historica del lasallismo en la educacion a traves de su  experiencia en Francia a partir de tres puntos claves: primero, al insertar a los hijos de los pobres al mundo social provoco que estos fueran actores de la transicion de un regimen de produccion tradicional a otro de caracter industrial; segundo, la congregacion lasallista procuro en su mision educativa el colocar en el centro a la persona, realizaron una importante aportacion a la incipiente idea de ciudadano que se gestaba en Francia; y tercero, los Hermanos contextualizaron la labor del maestro, su identidad y su papel en las escuelas.
Different dental tissues as source of DNA for human identification in forensic cases. (2003)

Cementoblasts and odontoblasts located within the cement and dentin are surrounded by the mineral matrix of the dental structure and thus protected from any environmental degradation forces, which makes them suitable sources for the DNA analysis.
Analysis of Heat Transfer Fouling by Dry‐Grind Maize Thin Stillage Using an Annular Fouling Apparatus (2006)

ABSTRACT In dry‐grind processing to produce ethanol from corn, unfermented solids are removed from ethanol by distillation and dried to produce distillers dried grains with solubles (DDGS), an animal food. Fouling of thin stillage evaporators has been identified as an important energy consumption issue in dry‐grind facilities. Using an annular fouling apparatus, four batches of thin stillage were analyzed to determine repeatability of fouling rate and induction period measurements. Dry solids, protein and ash concentrations, and pH were correlated to fouling rate and induction period to determine how variation in thin stillage from the same dry‐grind facility affects these fouling parameters. Effects of increasing Reynolds number (Re) in the laminar region on fouling rate, induction period, and fouling deposit protein and ash concentrations were also determined. Repeatability of fouling rate measurements was similar to other studies (CV < 7.0%) but repeatability of induction period measurements was high relative to other studies (CV < 88.7%). Fouling rate increased with increasing dry solids concentration. Thin stillage at Re = 440 had shorter induction periods and greater fouling rates than at Re = 880. Fouling deposits collected from Re = 440 tests had similar protein concentrations and lower ash concentrations compared with deposits from Re = 880 tests.
Felbamate Pharmacology and Use in Epilepsy (1994)

Felbamate, 2-phenyl-1,3-propanediol dicarbamate, is an antiepileptic drug recently approved by the United States Food and Drug Administration. It has a novel mechanism of action whereby it may decrease excitation by inhibiting glycine binding at the NMDA receptor, and it appears to have neuroprotective properties in addition to antiepileptic ones. A number of animal models have demonstrated felbamate to have a broad range of efficacy as well as a favorable safety profile. In humans it has been potentially linked to some cases of aplastic anemia. It is effective in the treatment of partial and secondarily generalized tonic-clonic seizures as well as seizures associated with the Lennox-Gastaut syndrome, especially drop attacks. It may also be effective against atypical absence as well as other seizure types. Felbamate monotherapy is generally well tolerated, with such side effects as insomnia and anorexia occurring most commonly. Felbamate shows great promise as a useful antiepileptic drug, but its role in clinical practice awaits further investigation of recently reported cases of aplastic anemia.