gebhart/patrepeval huggingface dataset:
Expression and regulation of CD5 on <i>in vitro</i> activated human B cells (1989)

The T cell-associated antigen CD5 has been shown to play an important role in the regulation of T cell activation. Monoclonal antibodies directed against CD5 upregulate helper function, and induce interleukin 2 (IL2) production by mature T cells as well as thymocytes. CD5 is also expressed on subsets of B cells associated with autoantibody production, and CD5+ B cells are present in increased numbers in patients with rheumatoid arthritis and systemic lupus erythematosis. More recently CD5 has been found to be present on human B lymphocytes following in vitro activation with phorbol myristate acetate. To date a similar functional role for CD5 has not to date been demonstrated for B cells. In this study we have shown that structurally similar CD5 molecules are present on activated B cells and T cells. In addition, CD5 on both stimulated B cells and T cells is phosphorylated, which may be important in the function of CD5 following activation. CD5 protein or mRNA was not detected on unstimulated splenic B cells depleted of any CD5+ cells. To investigate the control of CD5 expression, we examined a series of cytokines either alone or in combination for their effect on the induction of CD5. CD5 expression was specifically inhibited by IL4 but not by the other cytokines tested. This inhibition was very specific as IL4 did not inhibit the expression of other B cell activation antigens including CD25, B5, T9 and CD23 as well as the pan-B cell antigen CD20. The addition of other cytokines did not increase or reverse the inhibition of CD5 expression by IL4. This inhibition was demonstrated by immunofluorescence and flow cytometric analysis. Immunoprecipitation studies of 125I-labeled activated B cells demonstrated that there was a decrease in cell surface CD5 protein, and not simply inhibition of expression of a particular epitope. Northern blot analysis demonstrated that the expression of CD5 mRNA was markedly inhibited in the presence of IL4, whereas the induction of the protooncogene c-myb was unaffected. This suggests that IL4 inhibits CD5 protein expression on activated B cells by reducing the amount of CD5 mRNA transcription or increasing the degradation of CD5 mRNA. The role of the T cell-derived lymphokine IL4 in regulating CD5 expression may be important in the disease states characterized by increased numbers of CD5+ B cells.
Beating the channel capacity limit for superdense coding with entangled ququarts (2018)

Quantum superdense coding protocols enhance channel capacity by using shared quantum entanglement between two users. The channel capacity can be as high as 2 when one uses entangled qubits. However, this limit can be surpassed by using high-dimensional entanglement. We report an experiment that exceeds the limit using high-quality entangled ququarts with fidelities up to 0.98, demonstrating a channel capacity of 2.09 ± 0.01. The measured channel capacity is also higher than that obtained when transmitting only one ququart. We use the setup to transmit a five-color image with a fidelity of 0.952. Our experiment shows the great advantage of high-dimensional entanglement and will stimulate research on high-dimensional quantum information processes.
Pegylated Liposomal Doxorubicin Plus Docetaxel Significantly Improves Time to Progression Without Additive Cardiotoxicity Compared With Docetaxel Monotherapy in Patients With Advanced Breast Cancer Previously Treated With Neoadjuvant-Adjuvant Anthracycline Therapy: Results From a Randomized Phase III Study (2009)

The PLD-docetaxel combination was more effective than docetaxel alone in women with metastatic breast cancer who had experienced relapse at least 1 year after prior adjuvant anthracycline therapy without an increase in cardiac toxicity, although mucocutaneous toxicity was more common.
The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling: Implicating TIGAR in somatic resistance to endocrine therapy (2018)

Naturally-occurring somatic mutations in the estrogen receptor gene (ESR1) have been previously implicated in the clinical development of resistance to hormonal therapies, such as Tamoxifen. For example, the somatic mutation Y537S has been specifically associated with acquired endocrine resistance. Briefly, we recombinantly-transduced MCF7 cells with a lentiviral vector encoding ESR1 (Y537S). As a first step, we confirmed that MCF7-Y537S cells are indeed functionally resistant to Tamoxifen, as compared with vector alone controls. Importantly, further phenotypic characterization of Y537S cells revealed that they show increased resistance to Tamoxifen-induced apoptosis, allowing them to form mammospheres with higher efficiency, in the presence of Tamoxifen. Similarly, Y537S cells had elevated basal levels of ALDH activity, a marker of "stemness", which was also Tamoxifen-resistant. Metabolic flux analysis of Y537S cells revealed a hyper-metabolic phenotype, with significantly increased mitochondrial respiration and high ATP production, as well as enhanced aerobic glycolysis. Finally, to understand which molecular signaling pathways that may be hyper-activated in Y537S cells, we performed unbiased label-free proteomics analysis. Our results indicate that TIGAR over-expression and the Rho-GDI/PTEN signaling pathway appear to be selectively activated by the Y537S mutation. Remarkably, this profile is nearly identical in MCF7-TAMR cells; these cells were independently-generated <i>in vitro</i>, suggesting a highly conserved mechanism underlying Tamoxifen-resistance. Importantly, we show that the Y537S mutation is specifically associated with the over-expression of a number of protein markers of poor clinical outcome (COL6A3, ERBB2, STAT3, AFP, TFF1, CDK4 and CD44). In summary, we have uncovered a novel metabolic mechanism leading to endocrine resistance, which may have important clinical implications for improving patient outcomes.
Manufacturing classifications: relationships with production control systems (1999)

Since the early 1970s, production planning systems have evolved from material requirements planning (MRP) through manufacturing resource planning (MRPII) into enterprise resource planning (ERP) with simultaneous development of related control systems such as theory of constraints (epitomised by OPT), just‐in‐time (JIT), etc. One key area for all manufacturing companies is the planning and control function. There is a wide range of generic proprietary software available that aims to meet a company’s planning and scheduling requirements. The difficulty experienced by many companies is not only in examining available software, but also in understanding the match between business needs and the capabilities of that software. This paper first sets out some common manufacturing classification systems, then attempts to map them against accepted paradigms for production planning and control approaches. Analysis confirms the need for a more rigorous approach to software selection, and the need for a complete understanding of the drivers of the production control process before this can be achieved. The paper goes on to discuss a method for mapping these drivers, with the aim being to create a series of reference models for production planning and scheduling.
Cell type-specific proteins which interact with the 5' nontranslated region of hepatitis A virus RNA (1993)

The 5' nontranslated region (5'NTR) of hepatitis A virus (HAV) RNA contains structural elements which facilitate 5' cap-independent initiation of virus translation and are likely to interact with cellular proteins functioning as translation initiation factors. To define these interactions, we characterized the binding of ribosome-associated proteins from several cell types to synthetic RNAs representing segments of the 5'NTR by using a UV cross-linking/label transfer assay. Four major proteins (p30, p39, p57, and p110) were identified. p30 and p39 were present in ribosomal salt washes prepared only from HAV-permissive BS-C-1 and FRhK-4 cells, while p57 was found only in HeLa cells and rabbit reticulocyte lysates. p110 was present in all cell types. Both p30 and p39 bound to multiple sites within the 5'NTR. Efficient transfer of label to p30 occurred with minimal RNA probes representing nucleotides (nt) 96 to 155, 151 to 354, and, to a much lesser extent, 634 to 744, while label transfer to p39 occurred with probes representing nt 96 to 155 and 634 to 744. All of these probes represent regions of the 5'NTR which are rich in pyrimidines. Competitive inhibition studies indicated that both p30 and p39 bound with greater affinity to sites in the 5' half of the NTR (a probe representing nt 1 to 354) than to the more 3' site (nt 634 to 744). Binding of p39 to the probe representing nt 96 to 155 was inhibited in the presence of an equal amount of proteins derived from HeLa cells, suggesting that p39 shares binding site specificity with one or more HeLa cell proteins. A 57-kDa protein in HeLa cell protein extracts reacted with antibody to polypyrimidine tract-binding protein in immunoblots, but no immunoreactive protein was identified in a similar BS-C-1 protein fraction. These results demonstrate that ribosome-associated proteins which bind to the 5'NTR of HAV vary substantially among different mammalian cell types, possibly accounting for differences in the extent to which individual cell types support growth of the virus. Mutations in the 5'NTR which enhance the growth of HAV in certain cell types may reflect specific adaptive responses to these or other proteins.
On-load tap changer diagnosis: Interpretation of dynamic resistance deviations (2010)

This paper discusses the recently developed analysis method for service aged power transformers equipped with an OLTC: dynamic resistance measurements (DRM). Because the on-load tap changer contributes to many power transformer failures the emphasis is on OLTC diagnosis. Off-line diagnosis of on-load tap changers during regular maintenance can detect maintenance errors and assess the condition of OLTC parts not accessible for inspection. DRM can be valuable to on-load tap changer (OLTC) condition assessment because of the large variety of defects and OLTC degradation mechanisms that can be found. This paper deals with the results that can be measured with DRM. Besides undisturbed DRM-data, most common deviations originating from degraded and defect tap changers will be discussed. It is explained how these different types of defects appear in the DRM results. The location and shape of the deviation can be used to find the cause and importance of the defect. A subdivision is made between OLTC's in good condition, OLTC's with increased contact resistance, OLTC's with open contacts and OLTC's with deviating switch times. By doing so, an overview of possible DRM results is gained. The seriousness of the defects is also discussed in this paper. Differences between the DRM results of different types of OLTC's will be discussed by showing results of DRM tests. Most graphs presented in this paper are recorded on service-aged OLTC's in the Dutch utility grid. Some measurement results are performed during experiments in a high voltage laboratory.
Growth factor content in PRP and their applicability in medicine. (2013)

This paper reviews available reports on the advantages and possibilities of clinical use of platelet-rich plasma preparations, with particular emphasis on platelet growth factors. Platelets, an important reservoir of growth factors in the body, play an important role in many processes such as coagulation, immune response, angiogenesis and the healing of damaged tissues. Numerous proteins are contained in the alpha-granules of platelets: platelet-derived growth factor (PDGF), transforming growth factor (TGF), platelet factor interleukin (IL), platelet-derived angiogenesis factor (PDAF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor IGF and fibronectin. The development of methods and systems for blood and cell sorting (e.g. CAPSS - compact advanced platelet sequestration system Elektromedics 500, PCCS - platelet concentrate collection system Curasan) have made it possible to obtain significant concentrations of platelets (even by 338 percent) and high concentrations of growth factors, in a form of sterile mass that can be used immediately for clinical purposes. Platelet-rich plasma (PRP; autologous platelet-rich plasma - APRP) are platelet concentrates made of autogenous blood with a high number of platelets in a small volume of plasma. The clinical efficacy of platelet concentrates depends mainly on the number of platelets and the concentration of their growth factors, which act as transmitters in most processes in tissues, particularly in healing where they are responsible for proliferation, differentiation, chemotaxis and tissue morphogenesis. They operate as part of autocrine, paracrine and endocrine mechanisms. Growth factors derived from centrifuged blood were first used in patients with chronic skin ulcers. The clinical use of PRP for a wide variety of applications has been reported mostly in oral and maxillo-facial surgery, orthopedic surgery, treatment of soft tissue diseases and injuries, treatment of burns, hard-to-heal wounds, tissue engineering and implantology.
Australia, 1788(?) - Foundling of the Enlightenment? (1988)

An opinion is presented that the bicentenary celebration of Australia in 1988 is actually illusory, since Australia was not founded in 1788 but was only colonised. The processes involved in the evolution of the Australian nation since 1788 are discussed, suggesting that white Australian history should not be read as a foundling of the Enlightenment, but as a history which recognises the overlapping of whites and Aborigines as nationalist symbols of its Australianness.
Wearable Technology to Quantify the Nutritional Intake of Adults: Validation Study (2020)

This study documents high variability in the accuracy and utility of a wristband sensor to track nutritional intake, highlighting the need for reliable, effective measurement tools to facilitate accurate, precision-based technologies for personal dietary guidance and intervention.
최낭전 연구 ( 1 ) - 삽입서간을 중심으로 - (2000)

Choirangjeon deals with the genuine character, Yeotaek Lee(李汝澤), who lived in the Kyungju(慶州) province during King Hyojong`s(孝宗) regime in Lee Dynasty(朝鮮時代). The main motif of this work centers on the enactment of the new legal system, the main purpose of which is to locate all the hidden or run-away servants. About the authorship and the time it was written nothing is identifiable. However, considering the life span of Yeotaek Lee and the enactment of the new legal system, Choirangjeon is supposed to have been written during the late 17th century. The author is supposed to belong to the educated Yangban(兩班) class living in the southern part of Chosun. The main plot centers on the marriage between Yeotak Lee and Choirang(崔娘)and its tragic ending. The new legal system fated Choirang, whose grandmother had been the government servant, to fall under the servant status. Yeotaek Lee, after resolving her from becoming the servant by giving away of his three servants to the government, gets married with her. However, this caused him to be fired from his present job. Leaving Choirang behind, Yeoktaek goes up to Hanyang(漢陽) and finally becomes the major of Anju(安州) province. Their reunion, however, faces a tragic ending, for Choirang cannot survive the long and exhausting trip up to Hanyang. We are not certain yet how much portion of the story is real. However, considering Yeotaek`s identifiable status as the major of Heunghae(興海) and Anju(安州), we can assure that the author has created some fictional elements and mixed them in the real situation. To make more intriguing plot development, whenever the crisis is uprising, the author stops his own narration and intermingle letter writing. Thus used, the letter writing functions as one of the effective narrative techniques that succeeds in revealing characters` personalities and inner realities.
Impact of Buffer, Protein Concentration and Sucrose Addition on the Aggregation and Particle Formation during Freezing and Thawing (2018)

The overall goal of this research is to gain a better understanding of the freezing and thawing behaviour of mAb solutions with the ultimate aim to optimize this process step by reducing the unwanted particle formation, which also includes protein aggregates.
Identifying unambiguous frequency pattern for target localisation using frequency diverse array (2017)

The beampattern of a conventional frequency diverse array (FDA) with linear frequency pattern (i.e. the centre frequency of each antenna element is linearly increasing) is coupled in range and angle. FDA with random frequency pattern can decouple the range and angle with high probability only when the number of elements is sufficiently large. The ambiguity of frequency patterns that are random permutations of a linear FDA is examined. An eigenvector‐based criterion to identify possible ambiguity in target localisation using such arrays is proposed. Numerous results are presented to verify the effectiveness of the proposed ambiguity identification criterion.
Tái Khám Phá Niềm Vui Trong Đời Sống Hôn Nhân - Gia Đình Công Giáo (2023)

Niềm vui bên trong và niềm an ủi thâm sâu, Hội thánh hướng nhìn đến các gia đình kiên trung sống các giáo huấn của Tin mừng, cám ơn họ và khích lệ họ về chứng từ mà họ trao. Thật vậy, nhờ họ mà vẻ đẹp của hôn nhân bất khả phân li và trung tín, trở nên đáng tin. Trong gia đình, ‘vốn có thể gọi là Hội thánh tại gia’, ta được dần trưởng thành kinh nghiệm trong Hội thánh về mối hiệp thông giữa các ngôi vị, nơi đó, nhờ ân sủng, phản ánh chính mầu nhiệm Thiên Chúa Ba Ngôi. With inner joy and profound consolation, the Church looks to the families who faithfully live the teachings of the Gospel, thanking them and encouraging them for the testimony they give. Indeed, through them, the beauty of an indissoluble and faithful marriage becomes believable. In the family, 'which can be called the domestic church', we are gradually matured in the Church's experience of communion between persons, where, by grace, reflects the mystery of the Trinity.
Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis rats (2018)

Paeonol, as the main phenolic compound isolated from the Chinese herbs, has been confirmed to present anti-inflammatory effects on ulcerative colitis (UC) in our previous study. However, its poor solubility has hindered its development of being a favourable pharmaceutical product in treating colon diseases. In this study, we prepared the colon-specific delivery system (Pae-SME-CSC) with paeonol-loaded self-microemulsion (Pae-SMEDDS), and evaluated its in vitro and in vivo properties, especially the anti-inflammatory effects on UC rats. The anti-inflammatory effects were evaluated by the disease activity index, colon weight/length ratio, and macroscopic damage and microscopic damage scores. IL-17, IL-6, and TGF-β1 levels were also determined by enzyme-linked immunosorbent assay. The results showed that Pae-SME-CSC had good colon-targeting property in vivo and in vitro, with favourable stability. Efficacy evaluation showed that the dose of the paeonol group (100 mg/kg) exhibited no significant effect on UC (p > .05, compared with the model group), while the Pae-SME-CSC group (100 mg/kg) showed better anti-UC effects (p < .01 or p < .05), and its anti-inflammatory effect was close to that of the paeonol group (200 mg/kg) (p > .05). These results indicated that the developed Pae-SME-CSC was suitable for colon-specific drug delivery.
Estimating sustainability impact, total cost of ownership and dependability metrics on data center infrastructures (2011)

The advent of cloud computing has demanded more computational resources from data centers. Prominent issues are dependability, total cost of ownership and sustainability, which are significantly impacted by the redundant infrastructures needed to support cloud computing services. In this context, models are important to support data center designers to estimate previous issues before implementing the final infrastructure. This paper presents a set of formal models for estimating sustainability impact and dependability metrics in data center infrastructures with the support of an integrated environment, namely, ASTRO. Besides, we adopt reliability importance to identify the most critical components in system reliability in order to propose different data center power infrastructures.
Immunological properties of Hn-33 purified from type A Clostridium botulinum. (2000)

Type A botulinum neurotoxin is produced along with 6-7 neurotoxin associated proteins to form a complex in addition to the neurotoxin. Immunological reactivity of type A botulinum complex and purified hemagglutinin (Fu et al., 1998) to polyclonal antibody raised against the complex have been investigated using ELISA. In competitive ELISA, 50% inhibition of the binding of IgG antibody against complex A is observed at 78 ng/ml of complex and hemagglutinin-33, suggesting that the hemagglutinin-33 accounts for most of the immunogenic response of the complex. Considering the fact that the complex consists of a group of proteins with a cumulative molecular weight of 900 kDa, hemagglutinin-33 may be one of the major immunoreactive proteins present in the type A neurotoxin complex.
Calcium Channel Blockade and Contractile Responses in the Isolated Human Vas Deferens (1987)

The effects of removal of extracellular calcium and of the calcium channel blockers nifedipine, verapamil and diltiazem were studied on contractions induced by electrical field stimulation and high K+-solution in isolated preparations of the human vas deferens. Electrically induced contractions were blocked by tetrodotoxin and alpha-adrenoceptor blockade. They were abolished in calcium-deficient medium, and suppressed by the calcium channel blockers in the order of potency nifedipine greater than verapamil greater than diltiazem. The maximum blocking effect of nifedipine was approximately 40%. All the blockers practically abolished K+-induced contractions. It is concluded that even if the contractile response of the human vas deferens to electrical stimulation is dependent on extracellular calcium, calcium channel blockers seem to have only a limited effect on this contraction and their capability of impairing the function of the vas deferens in patients is questioned.
Interfacial reactions in a HfO2∕TiN/poly-Si gate stack (2006)

Interface reactions are investigated in a Si(100)∕SiO2∕HfO2∕TiN/poly-Si gate stack using electron-energy-loss spectroscopy. The electron-energy-loss near-edge fine structure on the core edges shows evidence of interface reactions having occurred between the TiN metal gate and surrounding layers. A Si(O,N) phase is observed at the TiN/poly-Si interface.
Research progress of gastric cancer stem cells and microenvironment (2011)

Cancer stem cells (CSC) have been defined as an unique subpopulation in tumors that possess the ability to initiate tumor growth and sustain tumor self-renewal. The tumor stem cell model proposes that tumor stem cells are the origin of most tumors. Accompanying with further extension in the investigation of cancer stem cells, the effects of niche that serves as'their microenvironment in tissue on the functions of cancer stem cells attract more and more attention, which plays important roles in maintaining the characteristics of cancer stem cells. It is essential to understand how cancer stem cells interact with their microenvironment. Although the evidence has been provided to support the existence of CSCs in various solid tumors, the identity of gastric CSCs has not been reported. In this review, we will examine gastric cancer stem cell niches and their impact on stem cell biology. The research on gastric cancer stem cell will provide new approaches for improved understanding of gastric cancer biology and gastric cancer treatment.

Key words: 
Stomach neoplasms;  Tumor stem cells;  Niche