gebhart/patrepeval huggingface dataset:
Cytochrome oxidase genes from Thermus thermophilus. Nucleotide sequence and analysis of the deduced primary structure of subunit IIc of cytochrome caa3. (1991)

Cytochrome caa3, a cytochrome c oxidase from Thermus thermophilus, is a two-subunit enzyme containing the four canonical metal centers of cytochrome c oxidases (cytochromes a and a3; copper centers CuA and CuB) and an additional cytochrome c. The smaller subunit contains heme C and was termed the C-protein. We have cloned the genes encoding the subunits of the oxidase and determined the nucleotide sequence of the C-protein gene. The gene and deduced primary amino acid sequences establish that both the gene and the protein are fusions with a typical subunit II sequence and a characteristic cytochrome c sequence; we now call this subunit IIc. The protein thus appears to represent a covalent joining of substrate (cytochrome c) to its enzyme (cytochrome c oxidase). In common with other subunits II, subunit IIc contains two hydrophobic segments of amino acids near the amino terminus that probably form transmembrane helices. Variability analysis of the Thermus and other subunit II sequences suggests that the two putative transmembrane helices in subunit II may be located on the surface of the hydrophobic portion of the intact cytochrome oxidase protein complex. Also in common with other subunits II is a relatively hydrophilic intermembrane domain containing a set of conserved amino acids (2 cysteines and 2 histidines) which have previously been proposed by others to serve as ligands to the CuA center. We compared the subunit IIc sequence with that of related proteins. N2O reductase of Pseudomonas stutzeri, a multi-copper protein that appears to contain a CuA site (Scott, R.A., Zumft, W.G., Coyle, C.L., and Dooley, D.M. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 4082-4086), contains a 59-residue sequence element that is homologous to the "CuA sequence motif" found in cytochrome oxidase subunits II, including all four putative copper ligands. By contrast, subunit II of the Escherichia coli quinol oxidase, cytochrome bo, also contains a region homologous to the CuA motif, but it lacks the proposed metal binding histidine and cysteine residues; this is consistent with the apparent absence of CuA from cytochrome bo.
<i>Ginkgo biloba</i> Extract Increases Ocular Blood Flow Velocity (1999)

We evaluated a possible therapeutic effect of Ginkgo biloba extract (GBE) on glaucoma patients that may benefit from improvements in ocular blood flow. A Phase I cross-over trial of GBE with placebo control in 11 healthy volunteers (8 women, 3 men: Age; 34 +/- 3 years, mean +/- SE) was performed. Patients were treated with either GBE 40 mg or placebo three times daily orally, for 2 days. Color Doppler imaging (Siemens Quantum 2000) was used to measure ocular blood flow before and after treatment. There was a two week washout period between GBE and placebo treatment. Ginkgo biloba extract significantly increased end diastolic velocity (EDV) in the ophthalmic artery (OA) (baseline vs GBE-treatment; 6.5 +/- 0.5 vs 7.7 +/- 0.5 cm/sec, 23% change, p=0.023), with no change seen in placebo (baseline vs GBE-treatment; 7.2 +/- 0.6 vs 7.1 +/- 0.5 cm/sec, 3% change, p=0.892). No side effects related to GBE were found. Ginkgo biloba extract did not alter arterial blood pressure, heart rate, or IOP. Ginkgo biloba extract significantly increased EDV in the OA and deserves further investigation in ocular blood flow and neuroprotection for possible application to the treatment of glaucomatous optic neuropathy as well as other ischemic ocular diseases.
Distributed Identity for Secure Service Interaction (2007)

People rely on physical identities and computers to access today's numerous services. It requires having various identity cards and typing of a good number of usernames and passwords daily to prove one's identity to the remote services. These create inconvenience in use and significant security vulnerability. In this paper, we present a concept of digital identity and thereby accessing services to solve this problem. It uses the mobile phone as identifier to one's digital identity. An individual is expected to exercise the similar real world roles in digital world through the proposed identity mechanism. Our goal is to develop a system that is both secure and usable.
Improved Culture System for Microspores of Barley to Become a Target for DNA Uptake (1991)

Abstract For the winter barley cultivar ‘Igri’, a microspore isolation and regeneration procedure is described which allows the production of such vigorous micro‐spore fractions that this single‐cell system can be used as a target for DNA uptake. Up to 60 % of the vigorous microspores isolated from the anther, and cultured in liquid modified MS medium, formed embryoids and/or calli. Such preparations were used for trials in DNA uptake with the plasmid pBI 221. Transformation trials were performed with polyethylene glycol as the inducing agent. With this treatment, a relative increase of fluorescence could be shown under UV light indicative of transient expression of the uidA gene.
Knowledge Graph Embedding for Link Prediction: A Comparative Analysis (2020)

Knowledge Graphs (KGs) have found many applications in industry and academic settings, which in turn, have motivated considerable research efforts towards large-scale information extraction from a variety of sources. Despite such efforts, it is well known that even state-of-the-art KGs suffer from incompleteness. Link Prediction (LP), the task of predicting missing facts among entities already a KG, is a promising and widely studied task aimed at addressing KG incompleteness. Among the recent LP techniques, those based on KG embeddings have achieved very promising performances in some benchmarks. Despite the fast growing literature in the subject, insufficient attention has been paid to the effect of the various design choices in those methods. Moreover, the standard practice in this area is to report accuracy by aggregating over a large number of test facts in which some entities are over-represented; this allows LP methods to exhibit good performance by just attending to structural properties that include such entities, while ignoring the remaining majority of the KG. This analysis provides a comprehensive comparison of embedding-based LP methods, extending the dimensions of analysis beyond what is commonly available in the literature. We experimentally compare effectiveness and efficiency of 16 state-of-the-art methods, consider a rule-based baseline, and report detailed analysis over the most popular benchmarks in the literature.
SoC CMOS UWB Pulse Radar Sensor for Contactless Respiratory Rate Monitoring (2011)

An ultra wideband (UWB) system-on-chip radar sensor for respiratory rate monitoring has been realized in 90 nm CMOS technology and characterized experimentally. The radar testchip has been applied to the contactless detection of the respiration activity of adult and baby. The field operational tests demonstrate that the UWB radar sensor detects the respiratory rate of person under test (adult and baby) associated with sub-centimeter chest movements, allowing the continuous-time non-invasive monitoring of hospital patients and other people at risk of obstructive apneas such as babies in cot beds, or other respiratory diseases.
Single Lithium Ion Conducting Polymer Electrolyte (1998)

Abstract : Because of the importance of this starting material, considerable effort was expended on modification of the reported workup. Elimination of all extraction and careful acidification of the diluted reaction mixture at low temperature leads to a consistent 40-50% yield of product exhibiting the characteristics of previously prepared samples. In addition to our interest in this material it appears to be an important starting material for the synthesis of anthracycline intermediates. Anthracyclines are used as antitumor antibiotics (c.f., Henry, D.W., Cancer. Treat. Rep 1979, 63, 845) in which they act as DNA intercalators. A publication specifying the details of the synthesis and workup is being prepared.
Brain Tumor Stem Cell Multipotency Correlates with Nanog Expression and Extent of Passaging in Human Glioblastoma Xenografts (2013)

Glioblastoma multiforme (GBM) is the most common primary brain tumor, with a median survival of only 15 months. A subpopulation of cells, the brain tumor stem cells (BTSCs), may be responsible for the malignancy of this disease. Xenografts have proven to be a robust model of human BTSCs, but the effects of long-term passaging have yet to be determined. Here we present a study detailing changes in BTSC multipotency, invasive migration, and proliferation after serial passaging of human GBM xenografts. Immunocytochemistry and tumorsphere formation assays demonstrated the presence of BTSCs in both early generation (EG-BTSCs; less than 15 passages) and late generation (LG-BTSCs; more than 24 passages) xenografts. The EG-BTSCs upregulated expression of lineage markers for neurons and oligodendrocytes upon differentiation, indicating multipotency. In contrast, the LG-BTSCs were restricted to an astrocytic differentiation. Quantitative migration and proliferation assays showed that EG-BTSCs are more migratory and proliferative than LG-BTSCs. However, both populations respond similarly to the chemokine SDF-1 by increasing invasive migration. These differences between the EG- and LG-BTSCs were correlated with a significant decrease in nanog expression as determined by qRT-PCR. Mice implanted intracranially with EG-BTSCs showed shorter survival when compared to LG-BTSCs. Moreover, differentiation prior to implantation of EG-BTSCs, but not LG-BTSCs, led to increased survival. Thus, nanog may identify multipotent BTSCs. Furthermore, limited passaging of xenografts preserves these multipotent BTSCs, which may be an essential underlying feature of GBM lethality.
3-D TV without glasses (1991)

A hologram-like, 3-D, high-resolution, stereoscopic video display technique based on a color CRT is described. The technique is unique in that it is autostereoscopic, i.e., no special glasses, goggles, panels, helmets, or two-channel optical systems are required by the viewer to see depth. Any image that can be put into a television-like format can be displayed. This allows real-time scanning sensor data to be viewed with depth in a format familiar to the viewer. An implementation using real-time sensors is shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Selectivity Enhancement for a Temperature Modulated Electronic Nose using Phase Space and Dynamic Moments (2012)

The present work describes an algorithm to enhance selectivity of metal oxide (MOX) gas sensors. The main objective is to improve gas discrimination performance of MOX sensor using a temperature modulation combined with phase space method. Our aim is to achieve a very good gas discrimination performance based on a fragment of sensor signal, rather than using the response of sensor for entire modulation signal. The basic principle behind this thesis work is that investigating in sensor response and extracting a segment with high class separability from a full modulation cycle of sensor response. The fragment of sensor signal is obtained by variable sliding window. A segment that gives more separable classes is taken for discriminating between a set of given analytes. In this work we demonstrate the developed algorithm with a single, commercially available MOX sensor, Figaro TGS 2620, which is temperature modulated with a sinusoidal waveform.
A&E staff ignore red-card ban for violent patients (2002)

Government guidelines on refusing treatment are proving unworkable, say nurses
A Study on the Development of a SPD with a built-in Disconnector Using Thermal Sensing Method for improving the applicability (2021)

Disconnectors shall be installed in the Surge Protective Device(SPD) to respond to failure of the SPD. The disconnectors can be installed inside or outside of the SPDs, most of which are installed externally. In this paper, we conducted an experiment to compare the cases in which the disconnector was installed inside and outside of the SPD. The results of the experiment confirmed that the value of the voltage protection level(U<SUP>p</SUP>) decreases when installed internally. Installing the SPDs built-in disconnector in electrical circuits can further enhance the protection effect of electrical and electronic equipment from surge caused by lightning, etc. In addition, in order to prevent faults such as thermal runaway of MOV, which is a device of voltage-limited SPD, a comparison experiment was conducted with a conventional method using low-temperature lead and a method using heat-sensor element, and it was confirmed that the effect was equivalent to preventing overheating of MOV. As a result, the SPD developed in this paper reduced the manufacturing cost of SPD by using cheaper elements for heat detection methods, and has higher reliability by obtaining KS certification.
New Iridium Complexes with Cyclometalated Alkenylquinoline Ligands as Highly Efficient Saturated Red‐Light Emitters for Organic Light‐Emitting Diodes (2005)

Electroluminescent devices using new iridium complexes (see Figure) (PEQ)2Ir(acetylacetonate (acac)), (MPEQ)2Ir(acac), and (PEIQ)2Ir(acac), as dopant emitters give saturated red light with very high brightness and efficiencies. For example, a (PEQ)2- Ir(acac)-based device showed Commission Internationale de L'Eclairage (CIE) coordinates (0.66, 0.33), brightness, and external quantum efficiency of 26400 cd m–2 and 7.23 %, respectively.
Models of multiple system atrophy (2019)

Multiple system atrophy (MSA) is a neurodegenerative disease with diverse clinical manifestations, including parkinsonism, cerebellar syndrome, and autonomic failure. Pathologically, MSA is characterized by glial cytoplasmic inclusions in oligodendrocytes, which contain fibrillary forms of α-synuclein. MSA is categorized as one of the α-synucleinopathy, and α-synuclein aggregation is thought to be the culprit of the disease pathogenesis. Studies on MSA pathogenesis are scarce relative to studies on the pathogenesis of other synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies. However, recent developments in cellular and animal models of MSA, especially α-synuclein transgenic models, have driven advancements in research on this disease. Here, we review the currently available models of MSA, which include toxicant-induced animal models, α-synuclein-overexpressing cellular models, and mouse models that express α-synuclein specifically in oligodendrocytes through cell type-specific promoters. We will also discuss the results of studies in recently developed transmission mouse models, into which MSA brain extracts were intracerebrally injected. By reviewing the findings obtained from these model systems, we will discuss what we have learned about the disease and describe the strengths and limitations of the models, thereby ultimately providing direction for the design of better models and future research.
Inclusion of polyvinylpyrrolidone in the polymerase chain reaction reverses the inhibitory effects of polyphenolic contamination of RNA (1999)

Polysaccharides, secondary metabolites and poly-phenolics are known to co-isolate with nucleic acids from plant tissues resulting in inhibition of molecular manipulations. RNA isolated from the polyphenolic-rich resurrection plant, Myrothamnus flabellifolius, was demonstrated to inhibit a standard polymerase chain reaction used as an assay despite the inclusion of the polyphenolic-binding compound poly(1-vinylpyrrolidone-2) (PVP) into the RNA isolation medium. This inhibition was, however, reversed by the addition of PVP into the PCR mixture itself. Confirmation of the inhibitory effect of polyphenolics on PCR was obtained by addition of green tea polyphenolics to the standard PCR assay. This inhibition was also reversed by the simultaneous inclusion of PVP.
The Effects of the Extracts from Tupistra Chinensis Bak. and Balanophora Involucrata HK.f. on the Content of Alcohol in Rats' Blood (2006)

Objective:To observe the effects of the extracts from Tupistra chinensis Bak.and Balanophora involucrata HK.f.on the content of alcohol in rats' blood.Method:The drunken rats were induced by admitting alcohol,with an agentjiejiujingas control group,then the content of alcohol in the medication administration and control groups were determined by means of acid dichromate oxidation method.Result:The content of alcohol in the rats' blood admitted the extracts of Tupistra chinensis Bak.and Balanophora involucrata HK.f.and their mixture was markedly lower than that of the model groups.Conclusion:The extracts of upistra chinensis Bak.and Balanophora involucrata HK.f.could decrease the content of alcohol in blood.
Surface Texture by 3D Printing (2018)

Three Dimensional Printing is a solid freeform fabrication process which creates parts\ndirectly from a computer model by depositing in layers. Each layer is created by depositing\npowder and selectively joining the powder with binder applied by a modulated ink-jet\nprinthead. This paper explores the application of 3D Printing to the manufacture of surface\ntextures, where the geometric freedom of 3D Printing is used to create repetitive millimeter\nand sub-millimeter surface structures with overhangs and undercuts. A related aspect of\nthe work concerns the development of computer representations of these complex\nstructures.\nIn one investigation, a "mushroom field" surface texture was modeled and printed. Each\nmushroom consists of a cylinder with a ball on top. These features are printed in a\nhexagonal array with each feature parallel to the local surface normal of a complex curved\nsurface. In another investigation, textures were printed into ceramic molds. The textures\nwere transferred to metal (tin-lead, CoCr) castings as positive surface features with\noverhangs and undercuts and typical dimensions of 700 x 350 x 350Jlm. The application\nofsuch cast textures to bone flXation in orthopaedic implants is discussed.
Simultaneous Automatic Electrochemical Detection of Zinc, Cadmium, Copper and Lead Ions in Environmental Samples Using a Thin-Film Mercury Electrode and an Artificial Neural Network (2014)

In this study a device for automatic electrochemical analysis was designed. A three electrodes detection system was attached to a positioning device, which enabled us to move the electrode system from one well to another of a microtitre plate. Disposable carbon tip electrodes were used for Cd(II), Cu(II) and Pb(II) ion quantification, while Zn(II) did not give signal in this electrode configuration. In order to detect all mentioned heavy metals simultaneously, thin-film mercury electrodes (TFME) were fabricated by electrodeposition of mercury on the surface of carbon tips. In comparison with bare electrodes the TMFEs had lower detection limits and better sensitivity. In addition to pure aqueous heavy metal solutions, the assay was also performed on mineralized rock samples, artificial blood plasma samples and samples of chicken embryo organs treated with cadmium. An artificial neural network was created to evaluate the concentrations of the mentioned heavy metals correctly in mixture samples and an excellent fit was observed (R2 = 0.9933).
Effects of Feeding Whole Cottonseed to Lactating Dairy Cows on Glucose and Palmitate Metabolism (1985)

Eight lactating Holstein dairy cows were fed corn silage-based diets with or without whole cottonseed at 18.5% of the dietary dry matter. At 42 days postpartum, a pulse injection of 100 mg glucose/kg body weight was given intravenously and plasma glucose concentration was monitored for 45 min. At 50 d postpartum, biopsies of adipose tissue and mammary tissue were taken and tissue slices were incubated in vitro with either uniform carbon-14 glucose or 1-carbon-14 palmitate. Basal concentration of plasma glucose was not affected by diet, although apparent distribution volume of glucose did seem to decrease due to feeding whole cottonseed. Feeding whole cottonseed decreased uptake of glucose and palmitate in both adipose tissue and mammary tissue and also decreased oxidation of glucose to carbon dioxide in both tissues. Palmitate oxidation was not affected by diet. Incorporation of carbon-14 from glucose into adipose tissue lipids was decreased in cows fed whole cottonseed. Results indicate that fat supplementation in the form of whole cottonseed may decrease palmitate incorporation and glucose utilization for glycerol and reducing equivalent synthesis in both adipose tissue and mammary tissue of lactating dairy cows.
Discussion and analysis on hygienic examination classroom instruction design (2009)

The level of classroom instruction design immediate influence teaching effect.At present,common existence questions of hygiene examination classroom teaching are that teaching design is unreasonable and poor efficiency.In view of this present situation,the article set off from teaching design principle,discusses the base element of hygiene examination teaching designs,and gives three kinds of rational science design model.A good result have been got.

Key words: 
Hygiene examination ; Teaching design; Model ; Discussion
Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells (2018)

Glioblastoma stem cells (GSCs) are invasive, treatment-resistant brain cancer cells that express downregulated in renal cell carcinoma (DRR), also called FAM107A, a genetic driver of GSC invasion. We developed antibody-antisense oligonucleotide (AON) conjugates to target and reduce DRR/FAM107A expression. Specifically, we used antibodies against antigens expressed on the GSCs, such as CD44 and EphA2, conjugated to chemically modified AONs against DRR/FAM107A, which were designed as chimeras of DNA and 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA) for increased nuclease stability and mRNA affinity. We demonstrate that these therapeutic conjugates successfully internalize, accumulate, and reduce DRR/FAM107A expression in patient-derived GSCs. This is the first example of an antibody-antisense strategy against cancer stem cells.
A Novel Bandwidth Scheduling Strategy for IEEE 802.16 Broadband Wireless Networks (2007)

WiMax system, which is defined by the IEEE 802.16 standard, also called broadband wireless metropolitan area network, supports real time and non-real time services. It has not defined the packet-scheduling algorithms, which was need for the requirement of quality of service (QoS) supporting for real-time services. Generally, the service station (SS) requests for bandwidth from the base station (BS), The BS then allocates the bandwidth to SS according to priority-based request. In this paper we propose a novel bandwidth scheduling algorithm for real time polling services (rtPS), the SS estimate the arrival of rtPS packets prior to the arrival and requests the BS for bandwidth in advance, based on the SS's request and the indeed bandwidth request by past. The analytical model and simulation show that, this adaptive algorithm provided better results with respect to the number of packets waiting at SS and average delay as compared to the widely accepted weighted scheduling algorithm and Mukul 's adaptive bandwidth request mechanism.
A 20Gb/s adaptive duobinary transceiver (2012)

A 20Gb/s adaptive duobinary transceiver has been realized in 90-nm CMOS technology. An adaptive transmitter is realized without a feedback channel. For the channels with different lengths, the tap coefficient of the transmitter is digitally adjusted to compensate the channel loss. It achieves a data rate of 20-Gb/s with a BER less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> over 16cm-FR4 board. The transmitter and receiver consume 81mW and 38mW from a 1.5V supply, respectively. For a 20-Gb/s PRBS of 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> -1, the maximum length of FR4 channel 16cm is achieved. The measured peak-to-peak jitter of the recovered data is 13.78ps.