gebhart/patrepeval huggingface dataset:
Antimicrobial efficacy of plant essential oils and extracts against <i>Escherichia coli</i> (2019)

The efficacies of 11 plant-derived antimicrobials were evaluated against <i>Escherichia coli in vitro</i> in solution at room temperature. These included lemongrass, cinnamon, and oregano essential oils and their active components (citral, cinnamaldehyde, and carvacrol, respectively). Allspice and clove bud oils and olive, green tea, and grape seed extracts were also studied. The efficacies of the antimicrobials were both concentration- and exposure time-dependent. The essential oils and their active components demonstrated statistically significant >5.0-log<sub>10</sub> reductions within 1-10 min. The plant extracts were less effective; green tea and grape seed extracts required 24 h before significant reductions were observed (1.93-log<sub>10</sub> and 5.05-log<sub>10</sub>, respectively). Nevertheless, olive extract exhibited a reduction of ∼5-log<sub>10</sub> within 30 min. Most of these plant-derived compounds exhibited strong bactericidal activity and can potentially be applied as alternatives to chemicals for foods/food contact surfaces since they are generally recognized as safe (GRAS) for human consumption. They may also be useful in applications in which other antimicrobials have reduced efficacy (e.g., in the presence of organics) or used with sensitive populations that are unable to tolerate exposure to harsher chemicals (e.g., elderly care facilities). These compounds could be used alone, in combination, or with fast-acting antimicrobials to provide a long-lasting residual.
Additives Which Prevent Gassing of Energetic Binder Containing Propellants. (1982)

Abstract : The invention describes a composition and a process for making void free solid propellants for rockets. This is accomplished by adding amino silanes and dimer diepoxide to GAP binder and deflagrating additive and then curing it. (Author)
Coronary arteries: breath-hold, gadolinium-enhanced, three-dimensional MR angiography. (1998)

The feasibility of three-dimensional (3D), single breath-hold, gadolinium-enhanced magnetic resonance (MR) coronary angiography was investigated. A 3D spoiled gradient-echo imaging technique was used to image the passage of intravenously injected paramagnetic contrast agent through the coronary vasculature in four healthy subjects. Image contrast depended solely on the injected contrast agent. 3D acquisition allowed retrospective reformation and display with maximum intensity projection and rendering algorithms.
ChemInform Abstract: Atomic Layer Deposition of Lithium Phosphorus Oxynitride. (2015)

Abstract LiPON thin films for potential use as a conformal solid‐state electrolyte coating in 3D Li‐ion microbattery technology are fabricated by simultaneously incorporating P and N via (Et‐O) 2 (NH 2 )PO together with LiN(Tms) 2 as the Li precursor.
The Future of Intracranial EEG Recording in Epilepsy: a Technological Issue? (2012)

Intracranial EEG information used for epilepsy surgery has been provided from large widely spaced electrodes over a narrow bandwidth. However, over the last decades, research on animal and more recently on human, promoted by increased interest in developing high-density microelectrode arrays (MEA), has opened new windows for the comprehension of seizure origin and propagation at a submillimeter scale. From an electrophysiological perspective MEA demonstrate to be able to record local field potentials recordings and possibly single units in the mouse cortex. The limitations on the number of channels that can be recorded simultaneously may limit the number of microelectrodes that can be considered and consequently the extent of brain coverage. Thanks to improving microfabrication techniques, several prototypes of MEA are under development and investigation. They will certainly play an important role in the improvement of the understanding of the complicated and evolving concept of epileptogenesis and provide the development of new strategies regarding neurosurgical therapeutic issues.
Synthesis and Biological Evaluation of <scp>d</scp>-Amino Acid Oxidase Inhibitors (2008)

D-amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids including d-serine, a full agonist at the glycine site of the NMDA receptor. A series of benzo[ d]isoxazol-3-ol derivatives were synthesized and evaluated as DAAO inhibitors. Among them, 5-chloro-benzo[ d]isoxazol-3-ol (CBIO) potently inhibited DAAO with an IC50 in the submicromolar range. Oral administration of CBIO in conjunction with d-serine enhanced the plasma and brain levels of d-serine in rats compared to the oral administration of d-serine alone.
A porcine gut polypeptide identical to the pancreatic hormone PP (pancreatic polypeptide) (1994)

A peptide hormone has been isolated from porcine intestine. Its primary structure was found to consist of 36 amino acid residues in a sequence identical to that of the porcine pancreatic polypeptide, previously not isolated from intestines or a tissue other than pancreas. The gut polypeptide significantly suppresses glucose-induced insulin secretion in vitro. Using an immunohistochemical technique, we also identified cells in the porcine gastrointestinal tract that were immunoreactive with pancreatic polypeptide. The immunoreactivity disappeared after absorption with the isolated gut polypeptide or synthetic human pancreatic polypeptide.
Development and Evaluation of a Dipstick Diagnostic Test for Neisseria meningitidis Serogroup X (2014)

The emergence of Neisseria meningitidis serogroup X (NmX) in the African meningitis belt has urged the development of diagnostic tools and vaccines for this serogroup, especially following the introduction of a conjugate vaccine against N. meningitidis serogroup A (NmA). We have developed and evaluated a new rapid diagnostic test (RDT) for detecting the capsular polysaccharide (cps) antigen of this emerging serogroup. Whole inactivated NmX bacteria were used to immunize rabbits. Following purification by affinity chromatography, the cpsX-specific IgG antibodies were utilized to develop an NmX-specific immunochromatography dipstick RDT. The test was validated against purified cpsX and meningococcal strains of different serogroups. Its performance was evaluated against that of PCR on a collection of 369 cerebrospinal fluid (CSF) samples obtained from patients living in countries within the meningitis belt (Cameroon, Côte d'Ivoire, and Niger) or in France. The RDT was highly specific for NmX strains. Cutoffs of 10(5) CFU/ml and 1 ng/ml were observed for the reference NmX strain and purified cpsX, respectively. Sensitivity and specificity were 100% and 94%, respectively. A high agreement between PCR and RDT (Kappa coefficient, 0.98) was observed. The RDT gave a high positive likelihood ratio and a low negative likelihood (0.07), indicating almost 100% probability of declaring disease or not when the test is positive or negative, respectively. This unique NmX-specific test could be added to the available set of RDT for the detection of meningococcal meningitis in Africa as a major tool to reinforce epidemiological surveillance after the introduction of the NmA conjugate vaccine.
Sit-to-Stand Trainer: An Apparatus for Training “Normal-Like” Sit to Stand Movement (2015)

Sit-to-stand (STS) transfer training is probably the most demanding task in rehabilitation. We have developed an innovative STS trainer that offers variable levels of mechanical support and speeds of STS transfer. In a group of neurologically intact individuals we compared kinematics, kinetics and electromyography (EMG) patterns of STS transfer assessed in three experimental conditions with increasing degree of mechanical support (MIN STS-T, MED STS-T, and MAX STS-T) to natural, unassisted STS movement (NO STS-T). The resulting ankle, knee, hip joint and trunk angles in experimental conditions MED STS-T and MIN STS-T were very similar to experimental condition NO STS-T. Vertical ground reaction forces and EMG patterns in the tibialis anterior, quadriceps and hamstrings show a clear trend toward "normal" patterns as the level of mechanical support from the device is progressively reduced. We have further tested the feasibility of the STS trainer in five stroke subjects at two levels of support showing that increased voluntary effort is needed when the support is reduced. Based on these results we conclude that negligible constraints are imposed by the device on a user's STS transfer kinematics, which is an important prerequisite for considering clinical use of the device for training in neurologically impaired.
Optical waveguide double-ring sensor using intensity interrogation with a low-cost broadband source (2011)

A highly sensitive optical waveguide sensor based on simple intensity interrogation with a broadband light source is proposed and investigated. It consists of two cascaded microring resonators with the same or slightly different free spectral ranges. The variation of the refractive index of the analyte sample results in a large shift in the envelope function of the transmission peaks of the sensor, and, consequently, a large change in the transmitted power. The low-cost sensing scheme can achieve an ultrahigh sensitivity of 2 × 10⁴ dB/RIU. Experimental results on the intensity interrogated double-ring sensor using a broadband source are presented, demonstrating its operation principle and potential for low-cost practical applications.
Preparation of Layered Ferroelectric Bi<sub>2</sub>SrTa<sub>2</sub>O<sub>9</sub> Single-Crystal Platelets (1996)

Layered ferroelectric Bi 2 SrTa 2 O 9 is attracting much attention as a fatigue-free material for ferroelectric nonvolatile memory devices. We have successfully synthesized this single-crystal platelet without any impurity phases by the self-flux method. The largest crystals measure about 1 mm×1 mm×5 µ m, and the lattice parameters were estimated to be a =0.5528 nm and c =2.498 nm, assuming a tetragonal cell. The chemical composition is 1.92:1.10:2.00 in an atomic ratio of Bi:Sr:Ta, from ICP-AES analysis. By wet etching, the crystal structure was found to be decomposed anisotropically, leaving only the c -axis framework. The step height of the topmost surface observed by atomic force microscopy (AFM) was 1.2 to 1.3 nm, which corresponds to half of the c -axis length (about 2.5 nm). Through thermal analysis, the thermal anomaly originating in ferroelectric-paraelectric phase transition was not observed and there was little evaporation of Bi compounds.
Development of permeability measuring instrument. (1991)

Recent electronic devices often use non-magnetic parts whose permeability is as low as less than 1.010, and that are becoming minute. It is difficult to measure their permeability using previous procedures. In order to resolve the problem, an improved instrument measuring permeability was prepared. It is based on a type of differential transformer where material is magnetized by an exciting coil and the resulting magnetic response is detected. The response consists of two parts due to the magnetization and to the eddy current involved. Using the finite element method for the analysis of electromagnetic field, the distribution of the magnetization and the eddy current within the material is estimated. On the basis of the analysis, an improved instrument measuring the permeability has been successfully developed and it is capable of detecting permeability less than 1.010 even in a small size part.
A model‐based framework for the detection of spiculated masses on mammographya) (2008)

The detection of lesions on mammography is a repetitive and fatiguing task. Thus, computer-aided detection systems have been developed to aid radiologists. The detection accuracy of current systems is much higher for clusters of microcalcifications than for spiculated masses. In this article, the authors present a new model-based framework for the detection of spiculated masses. The authors have invented a new class of linear filters, spiculated lesion filters, for the detection of converging lines or spiculations. These filters are highly specific narrowband filters, which are designed to match the expected structures of spiculated masses. As a part of this algorithm, the authors have also invented a novel technique to enhance spicules on mammograms. This entails filtering in the radon domain. They have also developed models to reduce the false positives due to normal linear structures. A key contribution of this work is that the parameters of the detection algorithm are based on measurements of physical properties of spiculated masses. The results of the detection algorithm are presented in the form of free-response receiver operating characteristic curves on images from the Mammographic Image Analysis Society and Digital Database for Screening Mammography databases.
Carbon-nanofiber-based probing arrays for multipoint integration with cellular matrices (2004)

The self-assembling and controlled synthesis properties of vertically-aligned carbon nanofibers (VACNF) have been exploited to provide parallel subcellular and molecular-scale probes for biological manipulation and monitoring. VACNFs possess many attributes that make them very attractive for implementation as functional, nanoscale features of microfabricated devices. For example, they can be synthesized at precise locations upon a substrate, can be grown many microns long, and feature sharp, nano-dimensioned tips. They also exhibit characteristic electrochemical responses similar to conventionally studied materials such as the edge plane of pyrolytic graphite and surface-activated glassy carbon. This, and their needlelike, vertical orientation upon a substrate, makes them particularly attractive as multielement cellular scale probes or as a parallel embodiment of traditional single-point microinjection or microelectrophysiological systems. We will overview our efforts at fabricating and characterizing several embodiments of VACNF cell probing systems. We will also overview surface modification techniques that exploit the rich surface chemistries of VACNF arrays to allow immobilization of active enzymes and transcriptionally active DNA, which can provide sensitivity to specific biological analytes and application of the nanofiber architecture for controlled biochemical manipulation within the cell. Finally, we will overview our techniques of integrating these probing structures with intact cells and how these structures may be used on a massively parallel basis for measurement and control of the intracellular domain.
Predicting Oxygen Uptake Responses During Cycling Using an Artificial Neural Network (2018)

PURPOSE: Oxygen Uptake (VO2) is a valuable metric for the prescription of exercise intensity and the monitoring of training progress. However, VO2 is difficult to measure in a non-laboratory setting. Conversely, heart rate (HR), which is intrinsically linked to VO2, is an easily obtained measure. Recently, VO2 predictions have been made during steady-state exercise using an artificial neural network (ANN). However, these previous models incorporated protocol-specific variables, making them unable to accurately estimate VO2 during arbitrary exercise intensities. Therefore, the purpose of this study was to predict VO2 during different exercise intensities with an ANN using HR and exercise intensity data. METHODS: 12 moderately-active adult males (age: 21.1 ± 2.5 years) performed a 50-minute bout of cycling at a variety of exercise intensities. VO2, HR, power output, and cadence were recorded throughout the test. An ANN was trained, validated and tested using the following inputs: HR, time derivative of HR, power output, cadence, and body mass. RESULTS: The ANN accurately predicted the experimental VO time series values throughout the test (R2 = 0.95, SEE = 1.7 mL/kg/min). conclusions: The predictive accuracy of this ANN is promising considering the large range of intensities and long duration of exercise. Future applications of this method could allow athletes to have accurate real-time VO2 predictions during exercise, improving the accuracy of training intensity.
Development of a conductive polymer, composite, direction-finding antenna (2003)

Traditionally, antennas have been fabricated from metals because of the required high electrical conductivity. Now, polymer materials with sufficiently high electrical conductivities have been developed and are commercially available. Inherent advantages of replacing metals with composites which utilize these polymers, include reduced radar cross sections (RCS), excellent corrosion resistance, and the ability to tailor specific electromagnetic properties. The application of conductive-polymer composites to direction-finding (DF) antennas is described. The normalized radar reflectivity is shown as a function of frequency for three different conductivity values of materials. A four-element crossed-dipole Adcock composite DF antenna assembly was designed, fabricated, and tested.
High-speed optical time-division multiplexed line- to base-rate clock recovery with an electro-optic phase locked loop (2002)

We present a simple and robust clock recovery technique which samples all OTDM channels, in which an electro-optic Mach Zehnder modulator (MZM) and a slow photodiode pair act as a phase detector driving a voltage-controlled oscillator (VCO) in a phase locked loop.
Recent progress in interface engineering of organic thin film transistors with self-assembled monolayers (2017)

This review introduces basic concepts and recent progress in self-assembled monolayers as a powerful tool for interface engineering of organic thin film transistors.
Effect of Aging on Ocular Light Scatter and Higher Order Aberrations (2002)

These results indicate that scatter was better correlated with age than higher order aberrations.
Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1<i>H</i>-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT<sub>6</sub>) Receptor Antagonist for Potential Treatment of Alzheimer’s Disease (2017)

Optimization of a novel series of 3-(piperazinylmethyl) indole derivatives as 5-hydroxytryptamine-6 receptor (5-HT<sub>6</sub>R) antagonists resulted in identification of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate (5al, SUVN-502) as a clinical candidate for potential treatment of cognitive disorders. It has high affinity at human 5-HT<sub>6</sub>R (K<sub>i</sub> = 2.04 nM) and selectivity over 100 target sites which include receptors, enzymes, peptides, growth factors, ion channels, steroids, immunological factors, second messengers, and prostaglandins. It has high selectivity over 5-HT<sub>2A</sub> receptor. It is orally bioavailable and brain penetrant with robust preclinical efficacy. The combination of 5al, donepezil, and memantine (triple combination) produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus. Preclinical efficacy in triple combination and high selectivity over 5-HT<sub>2A</sub> receptors are the differentiating features which culminated in selection of 5al for further development. The Phase-1 evaluation of safety and pharmacokinetics has been completed, allowing for the initiation of a Phase-2 proof of concept study.
Cucurbit[n]uril Derivatives Soluble in Water and Organic Solvents (2001)

Reminiscent of the ringed planet Saturn, new cucurbit[n]uril (CB[n]) derivatives CB*[5] and CB*[6] have rings decorating the "equator". The rings in this case are five- and six-fused cyclohexane rings, respectively (the structure of CB*[6] is shown). The remarkable solubility of the new CB[n] derivatives in water and organic solvents allows not only their unusual binding properties toward metal and organic ions in neutral water but also their applications in ion-selective electrodes to be studied.
S-Aryl-L-cysteine S,S-dioxides: design, synthesis, and evaluation of a new class of inhibitors of kynureninase (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTS-Aryl-L-cysteine S,S-dioxides: design, synthesis, and evaluation of a new class of inhibitors of kynureninaseRajesh K. Dua, Ethan W. Taylor, and Robert S. PhillipsCite this: J. Am. Chem. Soc. 1993, 115, 4, 1264–1270Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ja00057a007https://doi.org/10.1021/ja00057a007research-articleACS PublicationsRequest reuse permissionsArticle Views470Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MANTIS (2020)

The load on wireless cellular networks is not uniformly distributed through the day, and is significantly higher during peak periods. In this context, we present MANTIS, a time-shifted prefetching solution that prefetches content during off-peak periods of network connectivity. We specifically focus on YouTube given that it represents a significant portion of overall wireless data-usage. We make the following contributions: first, we collect and analyze a real-life dataset of YouTube watch history from 206 users comprised of over 1.8 million videos spanning over a 1-year period and present insights on a typical user's viewing behavior; second, we develop an accurate prediction algorithm using a K-nearest neighbor classifier approach; third, we evaluate the prefetching algorithm on two different datasets and show that MANTIS is able to reduce the traffic during peak periods by 34%; and finally, we develop a proof-of-concept prototype for MANTIS and perform a user study.
Responsive Surfaces: Magnetically Responsive Elastomer–Silicon Hybrid Surfaces for Fluid and Light Manipulation (Small 2/2018) (2018)

In article 1702839, Seok Kim and co-workers construct a magnetically responsive surface consisting of an array of silicon scales assembled on ferromagnetic elastomer micropillars. Multiple functions, such as droplet manipulation, structural coloration, and tunable optical transmission, are realized by incorporating a wide range of nanostructured silicon scales in a controlled configuration.
Measurement and Characterization of Channel Delays for Broadband Power Line Communications (2014)

Power Line Communications (PLC) emerged as a competitive technology for indoor broadband communications. It exploits the existing power line infrastructure for data transmissions. Transmission delays may essentially degrade the performance of applications relying on two-way communications such as videoconferencing, remote control systems, online games, and so on. Reported PLC channel models indirectly characterize signal propagation delays through channel transfer functions or impulse responses, but they do not address more important delays occurring because of multiple retransmissions of lost data packets in noisy PLC channels. This paper proposes a cost-efficient data delay measurement and a high-level statistical modeling approach for applications that are sensitive to data delays. Hybrid statistical distributions are explored for accurate delay characterization.