gebhart/patrepeval huggingface dataset:
Experimental and Kinetic Investigation of CO<sub>2</sub>and H<sub>2</sub>O/N<sub>2</sub>Gasification of Biomass Fuels (2011)

Characterization of the thermal decomposition of various woods, grasses and the biomass structural components, lignin and cellulose, was performed using a TGA with online GC analysis in both CO2 and H2O/N2 gasification environments. CO2 was observed to be a more efficient gasification environment that resulted in improved bio-char conversion during gasification. Introduction of CO2 as co-feed into the gasification environment resulted in enhanced CO and depressed H2 and CH4 concentrations enabling greater control in the syngas ratio produced by adjustment of the level of CO2 introduced. Mass decomposition and H2, CO, CO2 and CH4 gas evolution studies were performed for the various feedstocks at heating rates of from 1–100°C min-1 in both gasification media. When comparing the residual mass fractions of lignin and cellulose gasified in CO2 subjected to slow (1°C min-1) and fast (100°C min-1) heating rates, greater differential processing of the two components was possible with 65%, rather than 42%, of the lignin remaining following cellulose decomposition at the slow heating rate. Selective isolation of the thermally resistant lignin, retaining a greater residual fraction of this structural component, was observed during CO2 gasification at the lowest heating rates. While cellulose thermal decomposition was observed to occur over a narrow temperature window, ~275–425°C, thermal degradation of lignin occurs over a much wider range beginning about 175°C and finishing after 700°C with more than a 35% mass loss after 700°C in a CO2 gasification environment. A least squares best fit analysis for the global kinetic parameters gave an average pyrolysis activation energy for lignin and cellulose in CO2 as 43 and 211 kJ mol-1, while that for lignin and cellulose in H2O/N2 was 53 and 203 kJ mol-1, respectively. The analysis showed a pyrolysis best fit reaction order of three for lignin and one for cellulose. The various biomass feedstocks showed activation energies between 28–72 kJ mol-1 and reaction orders of one or two, with samples high in cellulose content showing correspondingly higher energies and lower reaction order.
Increased Oxidative Stress in Cultured 3T3-L1 Cells was Attenuated by Berberine Treatment (2015)

The 3T3-L1 cell line is one of the most well-characterized and reliable models for studying adipocytes. Increased oxidative stress in accumulated fat was found in 3T3-L1 cells. Berberine, an isoquinoline alkaloid, could suppress fat deposition in 3T3-L1 cells; however, whether berberine suppresses increased oxidative stress is not well known. In this study, we observed the effect of berberine on increased oxidative stress in 3T3-L1 cells. 3T3-L1 cells were cultured and treated with berberine (5-20 μM) from day 3 to day 8. We confirmed that berberine markedly inhibited fat accumulation and lipid droplets in 3T3-L1 adipocytes and decreased triglyceride content. Berberine inhibited increased oxidative stress in 3T3-L1 cells by suppressing reactive oxygen species (ROS) production, and increased glutathione peroxidase (GPx) gene expression and GPx activity. Berberine also markedly reduced adipokines secreted by adipocytes, including leptin and resistin.
Hybrid Dopamine Uptake Blocker–Serotonin Releaser Ligands: A New Twist on Transporter-Focused Therapeutics (2014)

As part of our program to study neurotransmitter releasers, we report herein a class of hybrid dopamine reuptake inhibitors that display serotonin releasing activity. Hybrid compounds are interesting since they increase the design potential of transporter related compounds and hence represent a novel and unexplored strategy for therapeutic drug discovery. A series of N-alkylpropiophenones was synthesized and assessed for uptake inhibition and release activity using rat brain synaptosomes. Substitution on the aromatic ring yielded compounds that maintained hybrid activity, with the two disubstituted analogues (PAL-787 and PAL-820) having the most potent hybrid activity.
Choosing a middleware for web-integration of a legacy application (2000)

Business applications today often face two contradictory constraints: they have to deal with heterogeneous platforms and at the same time meet the quality requirements. A larger number of middleware products are available to meet the first objective. An architect invariably faces a problem of picking up the right kind of middleware for the problem at hand. Fortunately, the second objective of quality requirements help an architect narrow down the choices of middleware. In this article, we demonstrate this fact through a project of web-integration of a legacy invoicing system.
New technique for nonintrusive OTDR based on trafficdata correlation (1994)

The authors present a new technique for nonintrusive optical time-domain reflectometry. The correlation of the transmitted traffic data with the backscattered signal allows the power attenuation of the optical link to be measured. Hence, as no additional signal is used, there is no reduction of the channel capacity. The application of nonlinear signal processing to improve the performance is also described.
Gait phase classification for in-home gait assessment (2017)

With growing ageing population, acquiring joint measurements with sufficient accuracy for reliable gait assessment is essential. Additionally, the quality of gait analysis relies heavily on accurate feature selection and classification. Sensor-driven and one-camera optical motion capture systems are becoming increasingly popular in the scientific literature due to their portability and cost-efficacy. In this paper, we propose 12 gait parameters to characterise gait patterns and a novel gait-phase classifier, resulting in comparable classification performance with a state-of-the-art multi-sensor optical motion system. Furthermore, a novel multi-channel time series segmentation method is proposed that maximizes the temporal information of gait parameters improving the final classification success rate after gait event reconstruction. The validation, conducted over 126 experiments on 6 healthy volunteers and 9 stroke patients with handlabelled ground truth gait phases, demonstrates high gait classification accuracy.
Automatic object detection in car-driving sequence using neural network and optical flow analysis (2014)

The increase in the number of vehicles has seen a rise in the accident rate. Pedestrians and vehicles on the move affect the behavior of the driver extensively. As an effort to reduce the number of accidents by assisting the driver, we propose a software system based on neural network and optical flow analysis to detect objects as observed by a driver. The proposed system tracks vehicles by detecting its number plate and the optical flow associated with it. It has four stages. First, the system is trained by using a number of images. In the second stage, object detection is performed for each image of the sequence using the trained system. Following this, the optical flow is calculated for each image as an estimate of the motion in the scene. In the fourth and final stage, optical flow is combined with the detected objects and both their direction and magnitude are identified. The results obtained detects cautions and alerts the driver about the impending dangerous situations that might befall. This software is also suitable for systems to study the behavior of the driver and if the software is used in all vehicles on the road, creating a database of the detected number plates, it can give the location of the stream of vehicles on the road.
IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc RIIb cross-linking (2006)

Although it has long been hypothesized that allergen immunotherapy inhibits allergy, in part, by inducing production of IgG Abs that intercept allergens before they can cross-link mast cell Fc epsilonRI-associated IgE, this blocking Ab hypothesis has never been tested in vivo. In addition, evidence that IgG-allergen interactions can induce anaphylaxis by activating macrophages through Fc gammaRIII suggested that IgG Ab might not be able to inhibit IgE-mediated anaphylaxis without inducing anaphylaxis through this alternative pathway. We have studied active and passive immunization models in mice to approach these issues and to determine whether any inhibition of anaphylaxis observed was a direct effect of allergen neutralization by IgG Ab or an indirect effect of cross-linking of Fc epsilonRI to the inhibitory IgG receptor Fc gammaRIIb. We demonstrate that IgG Ab produced during the course of an immune response or administered passively can completely suppress IgE-mediated anaphylaxis; that these IgG blocking Abs inhibit IgE-mediated anaphylaxis without inducing Fc gammaRIII-mediated anaphylaxis only when IgG Ab concentration is high and challenge allergen dose is low; that allergen epitope density correlates inversely with the allergen dose required to induce both IgE- and Fc gammaRIII-mediated anaphylaxis; and that both allergen interception and Fc gammaRIIb-dependent inhibition contribute to in vivo blocking Ab activity.
Association of<i>LOXL1</i>Gene Polymorphisms with Pseudoexfoliation in the Japanese (2008)

Polymorphisms in the LOXL1 gene confer risk to XFS/XFG in the Japanese, but there are different risk-associated alleles and haplotypes in the Japanese.
βPIX controls cell motility and neurite extension by regulating the distribution of GIT1 (2006)

Cell motility entails the reorganization of the cytoskeleton and membrane trafficking for effective protrusion. GIT1/p95-APP1 is a member of a family of GTPase-activating proteins for ARF GTPases that affect endocytosis, adhesion and migration. GIT1 associates with paxillin and a complex including the Rac/Cdc42 exchanging factors PIX/Cool and the kinase PAK. In this study, we show that overexpression of betaPIX induces the accumulation of endogenous and overexpressed GIT1 at large structures similar to those induced by an ArfGAP-defective mutant of GIT1 (p95-C2). Immunohistochemical analysis and immunoelectron microscopy reveal that these structures include the endogenous transferrin receptor. Time-lapse analysis during motogenic stimuli shows that the formation and perinuclear accumulation of the p95-C2-positive structures is paralleled by inhibition of lamellipodium formation and cell retraction. Both dimerization and a functional SH3 domain of betaPIX are required for the accumulation of GIT1 in fibroblasts, which is prevented by the monomeric PIX-PG-DeltaLZ. This mutant also prevents the formation of endocytic aggregates and inhibition of neurite outgrowth in retinal neurons expressing p95-C2. Our results indicate that betaPIX is an important regulator of the subcellular distribution of GIT1, and suggest that alteration in the level of expression of the complex affects the endocytic compartment and cell motility.
Simulation-Based Optimization of Multi Voltage Automotive Power Supply Systems (2013)

Complex multi-voltage automotive power supply systems are difficult to optimize. In this paper a simulation-based method to optimize multi voltage power supply systems is presented. With an electrical-thermal wire model the ampacity and the voltage drop of a cable can be determined. With these criteria cables of the power supply system can be dimensioned. By extending the electric-thermal models with functions defining costs, weight and space of the wires and DC/DC-converter models evaluation and optimization of multi-voltage vehicle systems is possible.
Mongersen, an oral Smad7 antisense oligonucleotide, in patients with active Crohn’s disease (2016)

In Crohn's disease (CD), the tissue-damaging inflammation is sustained by defects of counter-regulatory mechanisms, which normally inhibit immune-inflammatory signals and promote repair of mucosal injury. In particular, in inflamed gut of CD patients there are elevated levels of Smad7, an intracellular protein that inhibits the function of transforming growth factor (TGF)-β1. Knockdown of Smad7 with a specific antisense oligonucleotide, named mongersen, restores TGF-β1 activity thus leading to suppression of inflammatory pathways and resolution of colitis in mice. Consistently, oral administration of mongersen to patients with active CD induces clinical remission. In this article, we review the available data supporting the pathogenic role of Smad7 in CD and discuss the results of recent phase I and II trials assessing the efficacy and safety of mongersen in CD patients.
Potassium tert-butoxide complexed with a macrocyclic ligand for determination of autoprotolysis constant of tert-butanol and as a titrant (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotassium tert-butoxide complexed with a macrocyclic ligand for determination of autoprotolysis constant of tert-butanol and as a titrantI. M. Kolthoff and M. K. ChantooniCite this: Anal. Chem. 1979, 51, 8, 1301–1306Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ac50044a042https://doi.org/10.1021/ac50044a042research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
COLLABORATIVE NAVIGATION SIMULATION TOOL USING KALMAN FILTER WITH IMPLICIT CONSTRAINTS (2019)

Abstract. Collaborative Positioning (CP) is a networked positioning technique in which different multi-sensor systems (nodes) enhance the accuracy and precision of these navigation solutions by performing measurements or by sharing information (links) between each other. The wide spectrum of available sensors that are used in these complex scenarios bring the necessity to analyze the sensibility of the system to different configurations in order to find optimal solutions. In this paper, we discuss the implementation and evaluation of a simulation tool that allows us to study these questions. The simulation tool is successfully implemented as a plane based localization problem, in which the sensor measurements are fused in a Collaborative Extended Kalman Filter (C-EKF) algorithm with implicit constraints. Using a real urban scenario with three vehicles equipped with various positioning sensors, the impact of the sensor configuration is investigated and discussed by intensive Monte Carlo simulations. The results show the influence of the laser scanner measurements on the accuracy and precision of the estimation, and the increased performance of the collaborative navigation techniques with respect to the single vehicle method.
SERS Tags: Novel Optical Nanoprobes for Bioanalysis (2012)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSERS Tags: Novel Optical Nanoprobes for BioanalysisYunqing Wang†, Bing Yan‡, and Lingxin Chen*†View Author Information† Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China‡ School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China*Tel/Fax: +86 535 2109130. E-mail address: [email protected]Cite this: Chem. Rev. 2013, 113, 3, 1391–1428Publication Date (Web):December 28, 2012Publication History Received21 March 2012Published online28 December 2012Published inissue 13 March 2013https://pubs.acs.org/doi/10.1021/cr300120ghttps://doi.org/10.1021/cr300120greview-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views24285Altmetric-Citations1155LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Gold,Metal nanoparticles,Metals,Molecules,Raman spectroscopy Get e-Alerts
Assessment of potential gains in productivity due to proactive reticle management using discrete event simulation (1999)

Article Assessment of potential gains in productivity due to proactive reticle management using discrete event simulation Share on Authors: Sungmin Park Arizona State University, Tempe, AZ Arizona State University, Tempe, AZView Profile , John Fowler Arizona State University, Tempe, AZ Arizona State University, Tempe, AZView Profile , Matt Carlyle Arizona State University, Tempe, AZ Arizona State University, Tempe, AZView Profile , Matt Hickie Motorola MOS 12, Chandler, AZ Motorola MOS 12, Chandler, AZView Profile Authors Info & Claims WSC '99: Proceedings of the 31st conference on Winter simulation: Simulation---a bridge to the future - Volume 1December 1999 Pages 856–864https://doi.org/10.1145/324138.324537Published:01 December 1999 11citation159DownloadsMetricsTotal Citations11Total Downloads159Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Impact of modafinil on spasticity reduction and quality of life in children with CP (2008)

This randomized double blind AB/BA cross-over trial evaluates the effect of oral modafinil versus placebo on spasticity, function, and quality of life in children with cerebral palsy (CP). Outcomes were measured at the start and end of both 8-week treatment periods (modafinil and placebo). The order of the treatment periods was randomly assigned. There was a 4-week wash-out period between treatments. Primary outcomes include the Modified Ashworth Score (MAS), and the Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD), a disorder-specific quality of life measure. Ten children were randomized and eight children completed the study. The mean age of participants was 11 years 5 months (SD 1 y 5 mo, range 8 y 8 mo-12 y 11 mo). Five of the participants were male and three female. Seven children had a diagnosis of spastic quadriplegic CP and one child had spastic diplegia with overflow tone to the upper extremities. The Gross Motor Function Classification System ranged from Level III to V with one child at Level III, six children at Level IV, and one at Level V. The CPCHILD pre- to post-total scores showed a slight improvement in quality of life during the placebo period and a slight deterioration in the modafinil period (overall mean change of 7.1, SD 7.6). A t-test between post differences was statistically significant (t=2.65, p=0.03) in favor of the placebo period. The MAS for elbow flexors, ankle flexors, and hip adductors did not show any significant reduction post-modafinil or post-placebo (p values ranged from 0.41-0.79). This study did not find evidence that modafinil reduces spasticity or has a positive impact on quality of life in children with spastic CP.
Effects of <i>Kaempferia parviflora</i> extracts on reproductive parameters and spermatic blood flow in male rats (2008)

Krachaidum (KD, Kaempferia parviflora Wall. Ex. Baker), a native plant of Southeast Asia, is traditionally used to enhance male sexual function. However, only few scientific data in support of this anecdote have been reported. The present study investigated the effects of feeding three different extracts of KD (alcohol, hexane, and water extracts) for 3-5 weeks on the reproductive organs, the aphrodisiac activity, fertility, sperm motility, and blood flow to the testis of male rats. Sexual performances (mount latency, mount frequency, ejaculatory latency, post-ejaculatory latency) and sperm motility were assessed by a video camera and computer-assisted sperm analysis respectively, while blood flow to the testis was measured by a directional pulsed Doppler flowmeter. The results showed that all extracts of KD had virtually no effect on the reproductive organ weights even after 5 weeks. However, administration of the alcohol extract at a dose of 70 mg/kg body weight (BW)/day for 4 weeks significantly decreased mount and ejaculatory latencies when compared with the control. By contrast, hexane and water extracts had no influence on any sexual behavior parameters. All types of extracts of KD had no effect on fertility or sperm motility. On the other hand, alcohol extract produced a significant increase in blood flow to the testis without affecting the heart rate and mean arterial blood pressure. In a separate study, an acute effect of alcohol extract of KD on blood flow to the testis was investigated. Intravenous injection of KD at doses of 10, 20, and 40 mg/kg BW caused dose-dependent increases in blood flow to the testis. The results indicate that alcohol extract of KD had an aphrodisiac activity probably via a marked increase in blood flow to the testis.
Multiple Mini-Interviews (MMI) and Semistructured Interviews for the Selection of Family Medicine Residents: A Comparative Analysis (2014)

Background. Family Medicine Residency Program at the Aga Khan University has applicants for the residency position in excess of the positions offered resulting in formulation of certain selection criteria. The objective of this study was to compare MMI versus semistructured interviews for assessing noncognitive domains in the selection of residents. The secondary objectives were to determine perceptions of the interviewers and candidates for the acceptability and feasibility of MMI as a selection tool. Methods. The candidates underwent semistructured interviews along with MMI and identical attributes were tested in both. The attributes tested were safe doctor, communication skills, professionalism, problem solving, team approach, ethical issues, reasons for selecting family medicine, and commitment to the program. Descriptive statistics were calculated and comparison between ratings for MMI and interview was performed by Wilcoxon sign rank test. Results. Total number of candidates was 14. On comparison between interview and MMI, the scores were not statistically different for all attributes except ethics (mean interview scores: 3.04, mean MMI scores: 2.5, and P value 0.046). Conclusion. The study showed no difference between MMI and semistructured interviews. However, it needs to be replicated in order to determine the predictive validity and feasibility of MMI over time.