gebhart/patrepeval huggingface dataset:
Upgrading the Hydrogen Storage of MOF-5 by Post-Synthetic Exchange with Divalent Metal Ions (2021)

In metal-organic frameworks (MOFs), mixed-metal clusters have the opportunity to adsorb hydrogen molecules due to a greater charge density of the metal. Such interactions may subsequently enhance the gravimetric uptake of hydrogen. However, only a few papers have explored the ability of mixed-metal MOFs to increase hydrogen uptake. The present work reveals the preparation of mixed metal metal-organic frameworks M-MOF-5 (where M = Ni2+, Co2+, and Fe2+) (where MOF-5 designates MOFs such as Zn2+ and 1,4-benzenedicarboxylic acid ligand) using the post-synthetic exchange (PSE) technique. Powder X-ray diffraction patterns and scanning electron microscopy images indicate the presence of crystalline phases after metal exchange, and the inductively coupled plasma–mass spectroscopy analysis confirmed the exchange of metals by means of the PSE technique. The nitrogen adsorption isotherms established the production of microporous M-MOF-5. Although the additional metal ions decreased the surface area, the exchanged materials displayed unique features in the gravimetric uptake of hydrogen. The parent MOF-5 and the metal exchanged materials (Ni-MOF-5, Co-MOF-5, and Fe-MOF-5) demonstrated hydrogen capacities of 1.46, 1.53, 1.53, and 0.99 wt.%, respectively. The metal-exchanged Ni-MOF-5 and Co-MOF-5 revealed slightly higher H2 uptake in comparison with MOF-5; however, the Fe-MOF-5 showed a decrease in uptake due to partial discrete complex formation (discrete complexes with one or more metal ions) with less crystalline nature. The Sips model was found to be excellent in describing the H2 adsorption isotherms with a correlation coefficient ≅ 1. The unique hydrogen uptakes of Ni− and Co-MOF-5 shown in this study pave the way for further improvement in hydrogen uptake.
An Attention-Based Joint Acoustic and Text on-Device End-To-End Model (2020)

Recently, we introduced a two-pass on-device end-to-end (E2E) speech recognition model, which runs RNN-T in the first-pass and then rescores/redecodes the result using a noncausal Listen, Attend and Spell (LAS) decoder. This on-device model obtained similar performance to a state-of-the-art conventional model. However, like many E2E models, it suffers from being trained only on supervised audio-text pairs and thus performs poorly on rare words compared to a conventional model which incorporates a language model trained on a much larger text corpus. In this work, we introduce a joint acoustic and text decoder (JATD) into the LAS decoder, which makes it possible to incorporate a much larger text corpus into training. We find that the JATD model obtains in a 3-10% relative improvement in WER compared to a LAS decoder trained only on supervised audio-text pairs across a variety of proper noun test sets.
Evolution of Bearing Determination in HF Current Mapping Radars (1997)

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Enhancement of neutral lipid productivity in the microalga <i>Isochrysis</i> affinis <i>Galbana</i> (T‐Iso) by a mutation‐selection procedure (2012)

Microalgae offer a high potential for energetic lipid storage as well as high growth rates. They are therefore considered promising candidates for biofuel production, with the selection of high lipid-producing strains a major objective in projects on the development of this technology. We developed a mutation-selection method aimed at increasing microalgae neutral lipid productivity. A two step method, based on UVc irradiation followed by flow cytometry selection, was applied to a set of strains that had an initial high lipid content and improvement was assessed by means of Nile-red fluorescence measurements. The method was first tested on Isochrysis affinis galbana (T-Iso). Following a first round of mutation-selection, the total fatty acid content had not increased significantly, being 262 ± 21 mgTFA (gC)-1 for the wild type (WT) and 269 ± 49 mgTFA (gC)-1 for the selected population (S1M1). Conversely, fatty acid distribution among the lipid classes was affected by the process, resulting in a 20% increase for the fatty acids in the neutral lipids and a 40% decrease in the phospholipids. After a second mutation-selection step (S2M2), the total fatty acid content reached 409 ± 64 mgTFA (gC)-1 with a fatty acid distribution similar to the S1M1 population. Growth rate remained unaffected by the process, resulting in a 80% increase for neutral lipid productivity.
Progress in the Development of Selective Inhibitors of Aurora Kinases (2005)

Errors in the mitotic process are thought to be one of the principal sources of the genetic instability that hallmarks cancer. Unsurprisingly, many of the proteins that regulate mitosis are aberrantly expressed in tumour cells when compared to their normal counterparts. These may represent a good source of targets for the development of novel anti-cancer agents. The Aurora kinases represent one such family of mitotic regulators. In recent years there has been intense interest in both understanding the role of the Aurora kinases in cell cycle regulation and also in developing small molecule inhibitors as potential novel anti-cancer drugs. With several companies now starting to take Aurora kinase inhibitors into clinical development, the time is right to review the medicinal chemistry contribution to developing the field, in particular to review the increasingly broad range of small molecule inhibitors with activity against this kinase family.
Mass‐spectrometric evaluation of HLA‐A*0201‐associated peptides identifies dominant naturally processed forms of CTL epitopes from MART‐1 and gp100 (1999)

Melanoma-reactive human cytotoxic T lymphocytes (CTLs) mediate tumor regression in vivo through specific recognition of MHC-associated peptide epitopes, many of which are encoded by the melanocytic tissue differentiation proteins gp100/Pme117 and MART-1/Melan-A. Vaccines using these peptides may induce protective or therapeutic immunity against melanoma. Rational design of such approaches is aided by a clear understanding of the identity of these antigenic peptides; however, most CTL epitopes described to date were identified indirectly. Especially where these peptides may be used in human clinical trials for the treatment or prevention of cancer, there is substantial need for direct evaluation of HLA-A*0201-associated peptides from MART-1 and gp100 that are naturally processed and presented. To that end, we have isolated peptides directly from HLA-A*0201 molecules of human melanoma cells and have determined that naturally processed epitopes for HLA-A*0201-restricted, melanoma-reactive CTLs include the nonamers MART-1(27-35) (AAGIGILTV), gp100(154-162) (KTWGQYWQV), gp100(209-217) (ITDQVPFSV) and gp100(280-288) (YLEPGPVTA) and the decamer gp100(476-485) (VLYRYGSFSV). Among these, the one that appears to be most abundant at the cell surface is gp100(154-162) (KTWGQYWQV). The others are among the less abundant peptides. HLA-A*0201-restricted CTLs from one melanoma patient who has survived metastatic disease recognized MART-1(27-35) (AAGIGILTV), gp100(280-288) (YLEPGPVTA) and gp100(154-162) (KTWGQYWQV) and were cross-reactive on longer peptides that contained these nonamer sequences. These peptides, identified by both an indirect genetic approach and by a direct peptide approach, can be used for tumor vaccine strategies with confidence that they are identical to the naturally processed peptide epitopes presented at the surface of melanoma cells in association with HLA-A*0201 molecules.
<i>Hin</i> dIII Liposomes Suppress Delayed-Type Hypersensitivity Responses In Vivo and Induce Epidermal IL-10 In Vitro (1998)

Considerable evidence suggests that ultraviolet-B (UV-B) radiation suppresses certain immune responses through the induction of cyclobutane pyrimidine dimers in DNA. To determine whether induction of other forms of DNA damage in the skin mimicked the immunosuppressive effects of UV-B radiation, we produced double-strand breaks in the DNA of epidermal cells with HindIII restriction endonuclease encapsulated in liposomes. Application of these liposomes, but not liposomes containing inactive HindIII or an irrelevant endonuclease, to the skin of C3H mice suppressed the induction of delayed-type hypersensitivity responses to Candida albicans and alloantigen and induced IL-10 production in the epidermis. Treatment of the Pam212 murine keratinocyte cell line with these liposomes in vitro induced immunosuppressive activity and IL-10 in culture supernatants. Unlike UV-B irradiation, however, HindIII in liposomes failed to induce suppressor T cell activity in vivo or in vitro. We conclude that double-strand breaks in DNA of epidermal cells can induce immunosuppression and up-regulate the production of immunomodulatory cytokines; however, either DNA damage alone does not account for all the immunosuppressive properties of UV-B irradiation, or cyclobutane pyrimidine dimers differ qualitatively from double-strand breaks in their biologic consequences. These studies raise the possibility that drugs causing DNA damage may induce cytokine dysregulation and immune suppression in addition to cytotoxicity.
Closed-Form Expressions for Extending Step Delay and Slew Metrics to Ramp Inputs for RC Trees (2004)

Recent years have seen significant research in finding closed form expressions for the delay of an RC circuit that improves upon the Elmore delay model. However, several of these formulae assume a step excitation, leaving it to the reader to find a suitable extension to ramp-we always refer to saturated ramps in this paper-inputs. The few works that do consider ramp inputs do not present a closed-form formula that works for a wide range of possible input slews. We propose the PERI (probability distribution function extension for ramp inputs) technique, that extends delay metrics for step inputs to the more general and realistic non-step (such as a ramp) inputs. Although there has been little work done in finding good slew (which is also referred as signal transition time) metrics, we also show how one can extend a slew metric for step inputs to the non-step case. We validate the efficacy of our approach through experimental results from several hundred RC dominated nets extracted from an industry application specific integrated circuit design.
Abstract 3: Molecular markers of prostate cancer: Investigation of microRNA profiles as a marker in patients with high-risk prostate cancer. (2013)

Abstract Purpose: The aim of this study was to investigate the microRNA (miRNA) profile in prostate carcinoma as biomarkers to identify high-risk prostate cancer patients who may benefit from post-prostatectomy radiation therapy using global miRNA profiling. Method: Tumor from Formalin-Fixed Paraffin-Embedded (FFPE) tissues were obtained from 9 radical prostatectomy specimens resected for high-risk prostate cancer, to perform a pilot study using the Nanostring miRNA platform from isolated RNA. An optimized protocol utilizing the Ambion RecoverAll digestion buffer and the Qiagen miRNeasy FFPE kit was used to isolate total RNA. Each prostatectomy specimen was marked by a genitourinary pathologist and 1 mm cores of enriched areas of tumor or normal epithelial or stromal tissue were obtained. To analyze global miRNA expression, the Nanostring nCounter human miRNA Expression Assay Kit was used. The data was further analyzed in collaboration with The Ohio State University Center for Biostatistics. Results: The expression of miRNA in prostate tumor samples was compared to normal epithelium. It showed that seven miRNAs (miR-375, miR-18a, miR-25, miR-183, miR-641, miR-15b, miR-548a-3p) that were &gt;1.5-fold upregulated and 4 miRNAs (miR-660, miR-1915, miR-200b, miR-205) &lt;1.5-fold downregulated. Three (miR-375, miR-183, miR-205) were in accordance with previous studies published on prostate cancer. Expression of six up-regulated miRNAs (miR-205, miR-877, miR-K12-4-5p, miR-548b-3p, miR-34c-5p, ebv-miR-BART10) correlated with high risk (T&gt;3 and/or Gleason score ≥ 8) and five miRNAs (up-regulated: miR-10b, miR-205; down-regulated: miR-574-5p, miR-30c, miR-499-5p) with pathological tumor stage 2 and 3. Conclusion: Our results suggest great potential for the use of miRNA profiling as a novel diagnostic and prognostic biomarker in defining the signatures of prostate cancer at different stages. We are currently completing the RNA isolation and downstream analyses in correlation with clinical data for 80 additional high-risk prostate cancer cases from the University hospital of Freiburg, Germany. Citation Format: Petra Stegmaier, Simon Kirste, Xiaokui M. Mo, Debra L. Zynger, Arnab Chakravarti, Erica Hlavin Bell. Molecular markers of prostate cancer: Investigation of microRNA profiles as a marker in patients with high-risk prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3. doi:10.1158/1538-7445.AM2013-3
Simultaneous Assessment of Coronary Flow Reserve and Fractional Flow Reserve with a Novel Pressure‐Based Method (2000)

Coronary flow reserve (CFR) and fractional flow reserve (FFR myo ) are two guidewire‐based methods currently used to assess the functional severity of coronary artery lesions. Acquiring both measurements simultaneously may provide complementary information, but would require the passage of two different guidewires and complex instrumentation for their calculation. This study assessed the procedural safety and performance of a novel personal computer‐based algorithm, the SmartFlow Intravascular Processor (SFIP), which utilizes a single conventional pressure wire for obtaining simultaneous CFR and FFR myo measurements for the assessment of coronary artery lesion severity. In 20 consecutive patients with 21 lesions, pressure‐derived CFR, FFR myo and SFIP‐FFR myo measurements were obtained during adenosine‐induced hyperemia. Intravascular ultrasound and quantitative coronary angiography lesion analysis was done off‐line at the Washington Core Laboratory. Mean FFR myo was 0.83 ± 0.11, SFIP‐FFR myo was 0.86 ± 0.06, and CFR was 1.74 ± 0.46. Pairwise correlation analysis showed excellent correlation between the FFR myo and the FFR myo ‐SFIP (r 2 = 0.83, P < 0.0001) and a fair degree of relationship between the CFR and minimal lumen diameter (r 2 = 0.43, P = 0.07). We could not find a correlation between CFR and FFR myo (r 2 = 0.22, P = 0.37), between CFR and FFR‐SFIP (r 2 = 0.05, P = 0.86), or between the hemodynamic measurements and any of the IVUS‐derived measurements. In conclusion, the SFIP is u novel algorithm for obtaining simultaneous CFR and FFR myo that may provide valuable information for the assessment of lesion severity and clinical decision making.
Using Model-Based Diagnosis to Improve Software Testing (2014)

We propose a combination of AI techniques to improve softwaretesting. When a test fails, a model-based diagnosis(MBD) algorithm is used to propose a set of possible explanations.We call these explanations diagnoses. Then, a planningalgorithm is used to suggest further tests to identify thecorrect diagnosis. A tester preforms these tests and reportstheir outcome back to the MBD algorithm, which uses thisinformation to prune incorrect diagnoses. This iterative processcontinues until the correct diagnosis is returned. We callthis testing paradigm Test, Diagnose and Plan (TDP). Severaltest planning algorithms are proposed to minimize the numberof TDP iterations, and consequently the number of testsrequired until the correct diagnosis is found. Experimentalresults show the benefits of using an MDP-based planning algorithmsover greedy test planning in three benchmarks.
Novel way of making high refractive index plastics; metal containing polymers for optical applications (2009)

Abstract Plastics are being preferred in almost all possible applications of materials. Several new applications including optical devices are being developed using plastics replacing conventional materials like inorganic glass etc. For the optical applications, the most important properties of plastics essential for their desired performance include refractive index, Abbe number, optical clarity, etc. The biggest challenge in developing suitable materials for optical applications has always been to meet the criteria of high refractive index along with a high Abbe number. Normally, if the refractive index increases, the Abbe number automatically decreases. The researchers have tried several approaches to deal with this typical challenge without which it is not possible to develop novel optical plastics. Presently the most popularly known optical plastics includes polymers such as polymethacrylates, polyurethanes, polycarbonates, polystyrene and diethylene glycol bis allyl carbonate. The latest material of high refractive index plastics with a refractive index of 1.67 belongs to the polythiourethanes chemistry. Several approaches are being tried world over, to develop materials of high refractive index. One of the approaches being pursued for enhancement of refractive index of existing monomers pertain to the incorporation of metals or metal salts in the matrices. The other commonly tried but difficult to achieve approaches pertain to the preparation of nanoparticles or nanocomposites.
Reduction-Based Problem Mapping for Quantum Computing (2019)

In recent years, industry and academia have made tremendous research attempts to implement quantum computing technologies. But quantum computing is still grounded by numerous critical barriers, leading to its low accessibility and practicality. To overcome this problem, we propose an end-to-end framework for mapping computationally hard problems on a quantum computer via reduction.
Exemplar-based Sparse Representation phone identification features (2011)

Exemplar-based techniques, such as k-nearest neighbors (kNNs) and Sparse Representations (SRs), can be used to model a test sample from a few training points in a dictionary set. In past work, we have shown that using a SR approach for phonetic classification allows for a higher accuracy than other classification techniques. These phones are the basic units of speech to be recognized. Motivated by this result, we create a new dictionary which is a function of the phonetic labels of the original dictionary. The SR method now selects relevant samples from this new dictionary to create a new feature representation of the test sample, where the new feature is better linked to the actual units to be recognized. We will refer to these new features as S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pif</sub> . We present results using these new S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pif</sub> features in a Hidden Markov Model (HMM) framework for speech recognition. We find that the S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pif</sub> features allow for a 2.9% relative reduction in Phonetic Error Rate (PER) on the TIMIT phonetic recognition task. Furthermore, we find that the S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pif</sub> features allow for a 4.8% relative improvement in Word Error Rate (WER) on a large vocabulary 50 hour Broadcast News task.
High yield catalysts in olefin polymerization. General outlook on theoretical aspects and industrial uses (1984)

Abstract The new third generation Ziegler‐Natta catalysts give extremely high yield and produce highly stereoregular polypropylene of controlled morphology and size. The role of Lewis bases and MgCl 2 is underlined and their mechanisms of action is discussed in the light of the most significant experimental data. Furthermore, technological and economical advantages are emphasized.
Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species (2016)

Mesenchymal stem cells (MSCs) secrete exosomes that are capable of modifying the tumor environment through different mechanisms including changes in the cancer-cell secretome. This activity depends on their cargo content that is largely defined by their cellular origin. Endometrial cells are fine regulators of the angiogenic process during the menstrual cycle that includes an angiostatic condition that is associated with the end of the cycle. Hence, we studied the angiogenic activity of menstrual stem cells (MenSCs)-secreted exosomes on prostate PC3 tumor cells. Our results showed that exosomes induce a reduction in VEGF secretion and NF-κB activity. Lower reactive oxygen species (ROS) production in exosomes-treated cells was detected by the DCF method, suggesting that the inhibition of the intracellular ROS impacts both NF-κB and VEGF pathways. We confirmed using tubule formation and plug transplantation assays that MenSCs-exosomes suppress the secretion of pro-angiogenic factors by the PC3 cells in a ROS-dependent manner. The inhibition of the tumor angiogenesis and, consequently, the tumor growth was also confirmed using a xenograft mouse model. Additionally, the anti-tumoral effect was associated with a reduction of tumor hemoglobin content, vascular density and inhibition of VEGF and HIF-1α expression. Importantly, we demonstrate that the exosomes anti-angiogenic effect is specific to the menstrual cell source, as bone marrow MSCs-derived exosomes showed an opposite effect on the VEGF and bFGF expression in tumor cells. Altogether, our results indicate that MenSCs-derived exosomes acts as blockers of the tumor-induced angiogenesis and therefore could be suitable for anti-cancer therapies.
Efficient Extraction of Thioreodoxin from <i>Saccharomyces cerevisiae</i> by Ethanol (2007)

Thioredoxin, an antioxidant protein, is a promising molecule for development of functional foods because it protects the gastric mucosa and reduces the allergenicity of allergens. To establish a method for obtaining an ample amount of yeast thioredoxin, we found here that thioredoxin is released from Saccharomyces cerevisiae by treatment with 20% ethanol. We also found that Japanese sake contains a considerable amount of thioredoxin.
Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy (2019)

The proportion of nTreg at birth is a major determinant of the proportion present throughout infancy, highlighting the importance of prenatal immune development. Exposure to the inflammatory stimulus of labour appears to reveal differences in immune function among infants at risk of food allergy.
Frequency-resolved optical-gating measurements of ultrashort pulses using surface third-harmonic generation (1996)

We demonstrate what is to our knowledge the first frequency-resolved optical gating (FROG) technique to measure ultrashort pulses from an unamplified Ti:sapphire laser oscillator without direction-of-time ambiguity. This technique utilizes surface third-harmonic generation as the nonlinear-optical effect and, surprisingly, is the most sensitive third-order FROG geometry yet.