gebhart/patrepeval huggingface dataset:
Decimal multiplication via carry-save addition (2004)

Decimal multiplication is important in many commercial applications including financial analysis, banking, tax calculation, currency conversion, insurance, and accounting. We present two novel designs for fixed-point decimal multiplication that utilize decimal carry-save addition to reduce the critical path delay. First, a multiplier that stores a reduced number of multiplicand multiples and uses decimal carry-save addition in the iterative portion of the design is presented. Then, a second multiplier design is proposed with several notable improvements including fast generation of multiplicand multiples that do not need to be stored, the use of decimal (4:2) compressors, and a simplified decimal carry-propagate addition to produce the final product. When multiplying two n-digit operands to produce a 2n-digit product, the improved multiplier design has a worst-case latency of n+4 cycles and an initiation interval of n+1 cycles. Three data-dependent optimizations, which help reduce the multipliers' average latency, are also described. The multipliers presented can be extended to support decimal floating-point multiplication.
ChemInform Abstract: ANTIULCER AGENTS. 1. GASTRIC ANTISECRETORY AND CYTOPROTECTIVE PROPERTIES OF SUBSTITUTED IMIDAZO(1,2‐A)PYRIDINES (1985)

Abstract Die Verbindungen (I) und (II) cyclisieren zu den Imidazopyridinen (III), von denen (IV) als Antiulcusmittel für die klinische Erprobung ausgewählt wird.
High molecular mass polystannanes via dehydropolymerization of di(n-butyl)stannane (1993)

The dehydropolymerization of Bun2SnH2, catalysed by [Zr(C5H5)(C5Me5){Si(SiMe3)3}Me], produces cyclic (SnBun2)n oligomers and long H(SnBun2)nH polystannane chains (MwMn= 17 500/7800), which exhibit a long-wavelength electronic absorption (λmax= 382 nm) and emit green light (λmax= 505 nm; 337.1 nm excitation).
Nanomolar Inhibitors of <i>Staphylococcus </i><i>a</i><i>ureus</i> Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens (2002)

Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized compounds show excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics. Compound 11 demonstrated in vivo efficacy in an S. aureus rat abscess infection model.
3D printed on-package tripolar antennas for mitigating harsh channel conditions (2017)

A compact, 3D printed tripolar antenna operating at 2.4 GHz is presented. The antenna is designed for integration with a commercial wireless node in order to mitigate multipath and depolarization channel effects that could exist in many machine-to-machine deployments. The antenna substrate is fabricated with fused deposition modeling and the conductive layers by micro-dispensing silver paste. A median channel loss reduction of 4.3 dB is achieved in a Rayleigh fading environment using selection diversity.
Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures (2013)

The level of brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is down regulated in Alzheimer's disease (AD), Parkinson's disease (PD), depression, stress, and anxiety; conversely the level of this neurotrophin is increased in autism spectrum disorders. Thus, modulating the level of BDNF can be a potential therapeutic approach for nervous system pathologies. In the present study, we designed five different tetra peptides (peptides B-1 to B-5) corresponding to different active regions of BDNF. These tetra peptides were found to be non-toxic, and they induced the expression of neuronal markers in mouse embryonic day 18 (E18) primary hippocampal neuronal cultures. Additionally, peptide B-5 induced the expression of BDNF and its receptor, TrkB, suggesting a positive feedback mechanism. The BDNF peptides induced only a moderate activation (phosphorylation at Tyr 706) of the TrkB receptor, which could be blocked by the Trk's inhibitor, K252a. Peptide B-3, when combined with BDNF, potentiated the survival effect of this neurotrophin on H(2)O(2)-treated E18 hippocampal cells. Peptides B-3 and B-5 were found to work as partial agonists and as partial antagonists competing with BDNF to activate the TrkB receptor in a dose-dependent manner. Taken together, these results suggest that the described BDNF tetra peptides are neurotrophic, can modulate BDNF signaling in a partial agonist/antagonist way, and offer a novel therapeutic approach to neural pathologies where BDNF levels are dysregulated.
Permanent Hair Removal by Normal-Mode Ruby Laser (1998)

Permanent, nonscarring alopecia can be induced by a single treatment with high-fluence ruby laser pulses. Miniaturization of the terminal hair follicles seems to account for this response.
Nondestructive Identification of Natural and Synthetic Organic Colorants in Works of Art by Surface Enhanced Raman Scattering (2011)

We present a new method based on surface-enhanced Raman scattering (SERS) for the nondestructive identification of organic colorants in objects whose value or function precludes sampling, such as drawings, prints, historic and archeological textiles, handwritten or printed documents, and forensic evidence. A bead of a polymer hydrogel loaded with a solution containing water, an organic solvent, and a chelating agent is used to extract minimal amounts of the colorants from the work of art for SERS analysis. Using a gel as a medium for the solvent mixture confines its action only to the areas of the work of art covered by the gel bead. The gel bead is then removed from the work of art, covered with a drop of Ag colloid, and examined with a Raman microscope. Transfer of the dye from the substrate to the gel does not require removing a sample from the work of art, therefore preserving the physical integrity of the object. Spectrophotometric color measurements confirm that color change is below the limit perceivable by a human observer. Finally, the size of the polymer bead can be reduced to a fraction of a millimeter in order to further minimize any impact on the work of art, without detriment to the effectiveness of the method. The technique has been successfully used for the analysis of a mordant dye on the 15th century Netherlandish tapestry, "The Hunt for the Unicorn", and of a synthetic lake pigment on a Meiji period Japanese woodblock print.
Graph fractional-order total variation EEG source reconstruction (2016)

EEG source imaging is able to reconstruct sources in the brain from scalp measurements with high temporal resolution. Due to the limited number of sensors, it is very challenging to locate the source accurately with high spatial resolution. Recently, several total variation (TV) based methods have been proposed to explore sparsity of the source spatial gradients, which is based on the assumption that the source is constant at each subregion. However, since the sources have more complex structures in practice, these methods have difficulty in recovering the current density variation and locating source peaks. To overcome this limitation, we propose a graph Fractional-Order Total Variation (gFOTV) based method, which provides the freedom to choose the smoothness order by imposing sparsity of the spatial fractional derivatives so that it locates source peaks accurately. The performance of gFOTV and various state-of-the-art methods is compared using a large amount of simulations and evaluated with several quantitative criteria. The results demonstrate the superior performance of gFOTV not only in spatial resolution but also in localization accuracy and total reconstruction accuracy.
Torque-Balanced Singles Knitting Yarns Spun by Unconventional Systems (1997)

This paper is the first part of a series reporting on the recent development of a yarn modification process to produce torque-balanced singles spun yarns. Taking advantage of the core-sheath structure of unconventionally spun yarns, we have developed a yarn modification process and applied it to singles yarns spun by rotor spinning, producing torque-free singles yarns from 100% cotton fibers. The spirality of the resultant single jersey knit fabrics is greatly reduced or, in some cases, completely eliminated. Properties and performance characteristics of both parent and modified yarns, as well as their resultant fabrics, are evaluated, including yarn tensile properties, surface properties, handle, air permeability, burst strength, and pilling resistance of the fabrics.
ChemInform Abstract: Synthesis of Dodecahydro‐3a,6,6,9a‐tetramethyl‐naphtho(2,1‐b)furan via Alkoxy Radical Fragmentation. (1988)

Abstract The sclareol derivatives (Ib)‐(Id) can be used as precursors for the desired acetate (II).
Killing of Bacterial Spores Contained in a Paper Envelope by a Microwave Plasma Torch (2006)

The air plasma effluent of an arc-seed microwave torch is used to kill bacterial spores contained inside an envelope. The torch is operated at a 60-Hz periodic mode (with about 40% duty cycle) and runs stably at a low airflow rate (e.g., 0.393 l/s). The images of plasma torch plumes show that the arc loop of the discharge prolongs from the electrodes by nearly 3 cm and microwave energizes the charge particles along the arc loop considerably. The emission spectroscopy of the torch indicates that the plasma effluent contains an abundance of reactive atomic oxygen. Bacillus cereus is chosen for the biological agent in the decontamination experiment. The experiment and the decontamination efficacy of this torch are presented. The averaged temperature inside the envelope is measured to be less than 40degC, thus ruling out the thermal decontamination mechanism
Allosteric Enhancers for A1 Adenosine Receptor (2007)

Allosteric enhancers at the adenosine A(1) receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A(1) receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.
Where Notch and WNT Signaling Meet (2001)

The presenilins (PSs) are part of the molecular machinery responsible for cleaving proteins like the β-amyloid precursor protein (APP) and Notch in the plane of the membrane ([Annaert and De Strooper 1999][1]). Mutations in PS1 are one of the major causes of familiar Alzheimer's disease. PSs are
A New Poultry Semen Extender (1978)

Semen from adult Leghorns was subjected to one of five treatments during storage at 5 degrees C. for periods of up to 24 hr. The effects of dilution rate, storage temperature, presence of seminal plasma, presence of visible light and the semen to air ratio in the storage vessel were studied on the fertilizing capacity of spermatozoa after 0, 4 and 24 hr. of storage. The results indicated that the fertilizing capacity of chicken semen stored at 5 degrees C. was equal to that of the unstored controls when semen was diluted and exposed to a light intensity of 129 lux during the entire storage period. Viability of semen stored at 5 degrees C. for 24 hr. was unaffected by storage temperature (5 vs 15 degrees C.), the presence or absence of seminal plasma, or the semen to air ratio in the storage vessel.
High-Efficiency High-Power-Transfer-Density Capacitive Wireless Power Transfer System for Electric Vehicle Charging Utilizing Semi-Toroidal Interleaved-Foil Coupled Inductors (2019)

This paper presents a high-performance kilowatt-scale capacitive wireless power transfer (WPT) system for electric vehicle charging. This system achieves effective power transfer across a large air-gap by operating at a multi-MHz frequency (13.56 MHz), and by utilizing L-section matching networks that provide gain and reactive compensation. To achieve high efficiency at the high operating frequency, the matching network inductors are constructed as semi-toroidal structures with interleaved-foil coupled windings. This new coupled inductor design greatly reduces the inductor's ac resistance, with a measured 46% reduction compared to a conventional solenoidal coupled inductor. To further enhance performance, the matching network capacitors are comprised solely by the parasitic capacitances of the system, thereby eliminating on-board capacitors prone to dielectric breakdown and high-frequency losses. A 13.56-MHz 12-cm air-gap prototype capacitive WPT system incorporating these innovations is designed, built and tested. This system transfers 2.25 kW at an efficiency of 90%, achieving 29.6 kW/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> power transfer density. The system achieves even higher efficiencies at intermediate power levels, with a peak efficiency of 94% at 320 W, and 93% efficiency at 2 kW.
P‐196: <i>Late‐News‐Poster:</i> Low‐Temperature All Sputter IGZO‐TFT Fabricated with Amorphous Metal Thin‐Films (2020)

The flexibility, strength, and smoothness of amorphous metal thin‐films have enabled the development of a new generation of high‐performance diode and transistor devices for flat panel and thin‐film electronic applications. This work reports on recent progress toward the development of amorphous metal thin‐film transistors. The etch stop layer type transistors reported in this work demonstrate field effect mobilities as high as 20 cm 2 /V·s, depending on the processing conditions. All thin‐film layers for these amorphous metal thin‐film transistors were deposited using sputter physical vapor deposition techniques at room temperature. The low temperature processing, as well as the strong and flexible nature of amorphous metals, makes amorphous metal thin‐film transistor technology potentially useful for robust high‐speed highly flexible electronics.
A slot design for uniform aperture field distribution in single-layered radial line slot antennas (1991)

A single-layered radial line slot antenna (RLSA) is proposed for a direct broadcast from a satellite (DBS) subscriber antenna. It utilizes a radially outward-traveling wave and the aperture field is intolerably tapered if the uniform slots are used. Two novel techniques are applied. First, the slot design for uniform aperture field distribution is introduced. Second, the radial line is terminated by a matching spiral, in place of a dummy load. It suppresses reflection and radiates all the residual power in circular polarization. For a model antenna of 600-mm diameter, the efficiency of 65% is observed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cathodoluminescence of Terbium Activated Metaphosphate Glasses (1981)

Cathodoluminescent properties of several alkali and alkaline earth terbium metaphosphate glasses were investigated at an applied voltage of 100 V to 2500 V in a vacuum diode structure. Light outputs were compared with that from a Zn 2 SiO 4 :Mn (Pl) phosphor.
Investigation of the Scope of a New Route to ABCD-Bilanes and ABCD-Porphyrins (2008)

A new route to bilanes and porphyrins bearing four distinct meso substituents has been studied to elucidate the scope and gain entry to previously inaccessible compounds. The route entails (i) synthesis of a 1-bromo-19-acylbilane by acid-catalyzed condensation of a 1-acyldipyrromethane and a 9-bromodipyrromethane-1-carbinol and (ii) intramolecular cyclization of the 1-bromo-19-acylbilane in the presence of a metal salt (MgBr2, 3 mol equiv) and a non-nucleophilic base (DBU, 10 mol equiv) in a noncoordinating solvent (toluene) at 115 degrees C exposed to air to afford the corresponding magnesium(II) porphyrin. In this study, two sets of bilanes were initially prepared to explore substituent effects. In the first set, all bilanes vary only in the nature of the substituent at the 10-position. In the second set, all bilanes vary only in the nature of the substituent attached to the acyl unit (the 20-position). The substituents examined at the 10- and 20-positions include alkyl, aryl (electron-rich, electron-deficient, hindered), heteroaryl, ester, or no substituent (-H). The bilanes were obtained in 35-87% yield, and the target porphyrins in up to 60% yield. Further study of the scope focused on bilanes and porphyrins bearing three heterocyclic substituents (o-, m-, p-pyridyl) or four alkyl groups (ethyl, propyl, butyl, pentyl), in which case microwave irradiation was used for the porphyrin-forming step. Altogether, 17 bilanes and 19 porphyrins were prepared and characterized. In summary, the new route provides access to meso-substituted bilanes and porphyrins for which access is limited via other methods.
The analytic validation of prostate-specific mRNA detection in whole blood by RT-PCR as a prognostic biomarker for patients with castration-resistant prostate cancer (CRPC). (2012)

36 Background: To estimate the association between molecular biomarkers and outcomes, robust assays are needed before clinical qualification. Although tumor specific transcripts detected in blood by PCR have been associated with outcome, an analytically validated platform enabling detection of CTC-associated transcripts in clinical settings remains to be identified. Here we explore the efficacy of detecting a panel of prostate specific transcripts in CRPC. Methods: Blood was collected from 97 pts with progressive CRPC in PAXgene tubes (2.5 ml) for total RNA extraction using PAXgene Blood RNA Kit. Five genes expressed in prostate but not in nucleated blood cells were analyzed by RT-PCR. We used Fluidigm Dynamic Array platform to analytically validate RT-PCR assays for KLK3, KLK2, HOXB13, GHRL2, and FOXA1 transcripts. Each PCR-reaction was run in 6 replicates, detection thresholds for each gene were chosen by ROC analysis of an independent set of 56 CRPC patients versus 51 healthy volunteers, and results were reported as transcripts present or absent. CellSearch reported CTC number/7.5 ml of blood drawn into CellSave tube. Results: Prostate specific transcripts (≥ 2 genes) were detected in 52/97 (54%, 95% CI 43-64%) of patients with progressive CRPC studied with a median survival time of 17 months (95% CI: 13.8, 23.5). 40/45 CRPC-patients with ≥ 5 CTC and 15/52 CRPC patients with < 5 CTC had transcripts present in blood. Similar to CTC enumeration, transcript detection predicted overall survival in proportional hazards models that included LDH dichotomized at above and below 300. The predictive accuracy (CPE) of PCR detection + LDH was 0.785 (SE 0.036), comparable to CTC-enumeration + LDH (0.796, SE 0.035). Conclusions: Detecting prostate specific mRNA in whole blood using validated RT-PCR assays, applicable to larger CRPC cohorts, provides prognostic biomarkers that predict overall survival. The clinical utility in monitoring treatment will be prospectively explored. [Table: see text]
Liquid hydrophobic salts, their preparation and their application in electrochemistry (1996)

Patent number: 95-119462-718288 Reference LPI-PATENT-1996-002Search for this record at the European Patent Office Record created on 2006-02-21, modified on 2017-05-12
A versatile tiling light sheet microscope for cleared tissues imaging (2019)

Abstract We present a tiling light sheet microscope compatible with all tissue clearing methods for rapid multicolor 3D imaging of centimeter-scale cleared tissues with micron-scale (4×4×10 μm 3 ) to nanometer-scale (70×70×200 nm 3 ) spatial resolution. The microscope uses tiling light sheets to achieve a more advanced multicolor 3D imaging ability than conventional light sheet microscopes. The illumination light is phase modulated to adjust the 3D imaging ability of the microscope based on the tissue size and the desired spatial resolution and imaging speed, and also to keep the microscope aligned. The ability of the microscope to align via phase modulation alone also makes the microscope reliable and easy to operate. Here we describe the working principle and design of the microscope. We demonstrate its imaging ability by imaging various cleared tissues prepared by different tissue clearing and tissue expansion techniques.
SOFORT (2014)

Storage Class Memory (SCM) has the potential to significantly improve database performance. This potential has been well documented for throughput [4] and response time [25, 22]. In this paper we show that SCM has also the potential to significantly improve restart performance, a shortcoming of traditional main memory database systems. We present SOFORT, a hybrid SCM-DRAM storage engine that leverages full capabilities of SCM by doing away with a traditional log and updating the persisted data in place in small increments. We show that we can achieve restart times of a few seconds independent of instance size and transaction volume without significantly impacting transaction throughput.
Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity (2012)

These data show that treatment with orally bioavailable GABA-mimetic drugs if combined with spinal-segment-specific GAD65 gene overexpression can represent a novel and highly effective anti-spasticity treatment which is associated with minimal side effects and is restricted to GAD65-gene over-expressing spinal segments.
NonCartesian MR image reconstruction with integrated gradient nonlinearity correction (2015)

The proposed GNL-integrated nonCartesian reconstruction method can mitigate the resolution loss that occurs during standard image-domain GNL correction, while still providing effective correction of coarse-scale geometric distortion and blurring induced by GNL and off-resonance.
The use of a monoclonal antibody and of DNA recombinant technology for the localization of a poliovirus neutralization epitope in viral capsid polypeptide VP1. (1984)

Poliovirus cDNA sequences encoding type 1 capsid polypeptide VP1 were fused in phase into the beta-lactamase sequence of pBR322. The resulting recombinant plasmid pSW119 expressed in E. coli a VP1-beta-lactamase fusion protein which reacted with antibodies raised against poliovirus capsid polypeptide VP1 and with a monoclonal poliovirus type 1 neutralizing antibody C3. Deletions of various length were introduced into the VP1 sequence. The truncated proteins expressed by the deleted plasmids did not react further with C3 when the region of VP1 amino acids 91-104 was deleted. A synthetic peptide corresponding to this region of VP1 (amino acids 93-104) was chemically synthesized. It was found to inhibit the seroneutralization of poliovirus by C3 antibodies and, once coupled to keyhole limpet hemocyanin, it was specifically immunoprecipitated with C3. Therefore, the C3 epitope recognized by the poliovirus neutralizing monoclonal antibody is located within the region of amino acids 93-104 of capsid polypeptide VP1.