gebhart/patrepeval huggingface dataset:
Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression (2017)

<b>Purpose:</b> Lung cancer is the leading cause of cancer-related death in the United States. The molecular events preceding the onset of disease are poorly understood, and no effective tools exist to identify smokers with premalignant lesions (PMLs) that will progress to invasive cancer. Prior work identified molecular alterations in the smoke-exposed airway field of injury associated with lung cancer. Here, we focus on an earlier stage in the disease process leveraging the airway field of injury to study PMLs and its utility in lung cancer chemoprevention.<b>Experimental Design:</b> Bronchial epithelial cells from normal appearing bronchial mucosa were profiled by mRNA-Seq from subjects with (<i>n</i> = 50) and without (<i>n</i> = 25) PMLs. Using surrogate variable and gene set enrichment analysis, we identified genes, pathways, and lung cancer-related gene sets differentially expressed between subjects with and without PMLs. A computational pipeline was developed to build and test a chemoprevention-relevant biomarker.<b>Results:</b> We identified 280 genes in the airway field associated with the presence of PMLs. Among the upregulated genes, oxidative phosphorylation was strongly enriched, and IHC and bioenergetics studies confirmed pathway findings in PMLs. The relationship between PMLs and squamous cell carcinomas (SCC) was also confirmed using published lung cancer datasets. The biomarker performed well predicting the presence of PMLs (AUC = 0.92, <i>n</i> = 17), and changes in the biomarker score associated with progression/stability versus regression of PMLs (AUC = 0.75, <i>n</i> = 51).<b>Conclusions:</b> Transcriptomic alterations in the airway field of smokers with PMLs reflect metabolic and early lung SCC alterations and may be leveraged to stratify smokers at high risk for PML progression and monitor outcome in chemoprevention trials. <i>Clin Cancer Res; 23(17); 5091-100. ©2017 AACR</i>.
Methanation of Carbon Dioxide over Zeolite‐Encapsulated Nickel Nanoparticles (2018)

Abstract Efficient methanation of CO 2 relies on the development of more selective and stable heterogeneous catalysts. Herein, we present a simple and effective method to encapsulate Ni nanoparticles in zeolite silicalite‐1. In this method, the zeolite is modified by selective desilication, which creates intraparticle voids and mesopores that facilitate the formation of small and well‐dispersed nanoparticles upon impregnation and reduction. Transmission electron microscopy and X‐ray photoelectron spectroscopy analyses confirm that a significant part of the Ni nanoparticles are situated inside the zeolite rather than on the outer surface. The encapsulation results in increased metal dispersion and, consequently, high catalytic activity for CO 2 methanation. With a gas hourly space velocity of 60 000 mL g catalyst −1 h −1 and H 2 /CO 2 =4, the zeolite‐encapsulated Ni nanoparticles result in 60 % conversion at 450 °C, which corresponds to a site‐time yield of approximately 304 mol mol Ni −1 h −1 . The encapsulated Ni nanoparticles show no change in activity or selectivity after 50 h of operation, although postcatalysis characterization reveals some particle migration.
Compositions involving V sub 2 O sub 3 minus Al sub 2 O sub 3 minus TiO sub 2 (1990)

This patent describes an oxidation catalyst or refractory and the method for its preparation. The material comprises substitutional solid solutions involving V{sub 2}O{sub 3}, Al{sub 2}O{sub 3} and TiO{sub 2} and having compositions that fall within a specific polygon in a ternary composition diagram of V{sub 2}O{sub 3}, Al{sub 2}O{sub 3} and TiO{sub 2}. A typical material has the formula Al{sub 0.65}V{sub 1.7}{sup 7}Ti{sub 0.69}O{sub 5}.
Appearance of high-temperature phase in zirconia films made by aerosol gas deposition method (2011)

The aerosol gas deposition method (AGD) is a low-temperature method. No heating occurs during the AGD process when forming the AGD films. Nevertheless, ceramic films can be synthesized at room temperature directly from the source ceramic powders. In this paper, we report that the high-temperature phase of zirconia was found in zirconia films synthesized by AGD and that a light emission phenomenon was observed at the deposition site. The generation of the high-temperature phase was dependent on the mean diameter of the source ceramic powders. Both a small powder of less than two or three microns in diameter and large powder particles of more than 10 microns in diameter have the low possibility of generating the high-temperature phase when compared to that of 7-micron diameter powder. The appearance of the high-temperature phase and the light emission might be related to the formation mechanism of the AGD film at ambient temperature.
A nomogram for calculation of the wet bulb – globe temperature index (1970)

A device is described that facilitates the calculation of the wet bulb – globe temperature index. It consists of a small nomogram on which two scales, representing the dry bulb temperature, the natural wet bulb temperature, and the globe temperature, are inscribed so that reference to these scales with two movable cursors results in computation of the WBGT index at a third scale.
Acoustic degasification of pressurized liquids (1983)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Lynn Faulkner, Foster B. Stulen; Acoustic degasification of pressurized liquids. J. Acoust. Soc. Am. 1 March 1983; 73 (3): 1089. https://doi.org/10.1121/1.389120 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Open‐Pore Two‐Dimensional MFI Zeolite Nanosheets for the Fabrication of Hydrocarbon‐Isomer‐Selective Membranes on Porous Polymer Supports (2016)

Two-dimensional zeolite nanosheets that do not contain any organic structure-directing agents were prepared from a multilamellar MFI (ML-MFI) zeolite. ML-MFI was first exfoliated by melt compounding and then detemplated by treatment with a mixture of H2 SO4 and H2 O2 (piranha solution). The obtained OSDA-free MFI nanosheets disperse well in water and can be used for coating applications. Deposits made on porous polybenzimidazole (PBI) supports by simple filtration of these suspensions exhibit an n-butane/isobutane selectivity of 5.4, with an n-butane permeance of 3.5×10(-7) mol m(-2) s(-1) Pa(-1) (ca. 1000 GPU).
Conductive Interstitial Thermal Therapy (CITT) Device Evaluation in VX2 Rabbit Model (2007)

We have developed a conductive interstitial thermal therapy (CITT) device to precisely and reliably deliver controlled thermal doses to the surgical margins at the cavity site following tumor resection, intraoperatively. The temperature field created by CITT ablation of a perfused tissue was modeled with a finite element package Femlab. The modeling suggested that a maximum probe temperature of 120 degrees C and an ablation time of 20 minutes were required to ablate highly perfused tissue such as the VX2 carcinoma. Deployable pins enable faster and more reliable thermal ablation. The model predictions were tested by thermal ablation of VX2 carcinoma tumors implanted in adult New Zealand rabbits. The size of the ablated region was confirmed with a viability stain, triphenyltetrazolium chloride (TTC). Histopathological examination revealed 3 regions in the ablated area: a carbonized region (1-3 mm); a region that contained thermally fixed cells; and an area of coagulated necrosis cells. Cells in the thermally fixed region stained for PCNA (proliferating cell nuclear antigen) and were bounded by the carbonized layer at the cavity wall, and by necrotic cells that exhibit nuclear fragmentation and cell dissociation, 5 to 10 mm away from the CITT probe. Adjacent tissue outside the target region was spared with a clear demarcation between ablated and normal viable tissue. It is suggested that the CITT device can be used, clinically, to inhibit local recurrence by creating negative surgical margins following the resection of a primary tumor in non-metastatic early staged tumors.
Obtaining Large Columnar CdTe Grains and Long Lifetime on Nanocrystalline CdSe, MgZnO, or CdS Layers (2018)

Abstract CdTe solar cells have reached efficiencies comparable to multicrystalline silicon and produce electricity at costs competitive with traditional energy sources. Recent efficiency gains have come partly from shifting from the traditional CdS window layer to new materials such as CdSe and MgZnO, yet substantial headroom still exists to improve performance. Thin film technologies including Cu(In,Ga)Se 2 , perovskites, Cu 2 ZnSn(S,Se) 4 , and CdTe inherently have many grain boundaries that can form recombination centers and impede carrier transport; however, grain boundary engineering has been difficult and not practical. In this work, it is demonstrated that wide columnar grains reaching through the entire CdTe layer can be achieved by aggressive postdeposition CdTe recrystallization. This reduces the grain structure constraints imposed by nucleation on nanocrystalline window layers and enables diverse window layers to be selected for other properties critical for electro‐optical applications. Computational simulations indicate that increasing grain size from 1 to 7 µm can be equivalent to decreasing grain‐boundary recombination velocity by three orders of magnitude. Here, large high‐quality grains enable CdTe lifetimes exceeding 50 ns.
A Low Jitter 1.6 GHz Multiplying DLL Utilizing a Scrambling Time-to-Digital Converter and Digital Correlation (2007)

This paper presents a 1.6 GHz multiplying delay-locked loop (MDLL) that leverages time-to-digital conversion and a digital correlation technique to achieve low deterministic jitter while still maintaining low random jitter. A proposed time-to-digital converter consists of a ring oscillator that is gated on and off to accurately measure time and scramble the measurement's residual error. Using a 50 MHz reference, the prototype system has measured reference spurs less than -59 dBc and an overall measured jitter of 1.41 ps.
Improvement of system capacitance via weavable superelastic biscrolled yarn supercapacitors (2016)

Yarn-based supercapacitors having improved performance are needed for existing and emerging wearable applications. Here, we report weavable carbon nanotube yarn supercapacitors having high performance because of high loadings of rapidly accessible charge storage particles (above 90 wt% MnO<sub>2</sub>). The yarn electrodes are made by a biscrolling process that traps host MnO<sub>2</sub> nanoparticles within the galleries of helically scrolled carbon nanotube sheets, which provide strength and electrical conductivity. Despite the high loading of brittle metal oxide particles, the biscrolled solid-state yarn supercapacitors are flexible and can be made elastically stretchable (up to 30% strain) by over-twisting to produce yarn coiling. The maximum areal capacitance of the yarn electrodes were up to 100 times higher than for previously reported fibres or yarn supercapacitors. Similarly, the energy density of complete, solid-state supercapacitors made from biscrolled yarn electrodes with gel electrolyte coating were significantly higher than for previously reported fibre or yarn supercapacitors.
Three polymorphic dinucleotide repeats near the von Hippel Lindau (VHL) disease gene on human chromosome 3:D3S587; D3S1317; D3S1435 (1993)

Journal Article Three polymorphic dinucleotide repeats near the von Hippel Lindau (VHL) disease gene on human chromosome 3:D3S587; D3S1317; D3S1435 Get access Hua Li, Hua Li Search for other works by this author on: Oxford Academic PubMed Google Scholar Laura Schmidt, Laura Schmidt Search for other works by this author on: Oxford Academic PubMed Google Scholar Fuh-Mei C. Duh, Fuh-Mei C. Duh Search for other works by this author on: Oxford Academic PubMed Google Scholar Ming-Hui Wei, Ming-Hui Wei Search for other works by this author on: Oxford Academic PubMed Google Scholar Farida Latif, Farida Latif 1Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development CenterFrederick, MD 21702, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas Stackhouse, Thomas Stackhouse Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael I. Lerman, Michael I. Lerman 1Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development CenterFrederick, MD 21702, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Berton Zbar, Berton Zbar 1Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development CenterFrederick, MD 21702, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Kalman Tory Kalman Tory * * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 2, Issue 8, August 1993, Page 1326, https://doi.org/10.1093/hmg/2.8.1326 Published: 01 August 1993
Noninvasive vibration measurement system and method for measuring amplitude of vibration of tissue in an object being investigated (1989)

First Page
Novel technique for growth-etch cycling of flame-deposited diamond films (1994)

We have developed a novel technique for growth-etch cycling of diamond films deposited with an oxygen-acetylene torch, whereby a spinning wheel with removable teeth periodically disrupts the depositing flame in open atmosphere to allow air etching of a heated substrate. Cycling times as short as 0.02 s, with a growth/etch time ratio of approximately 19, have produced films with macro-Raman peak widths (full width at half-maximum) of approximately 3 cm−1. A predominance of large 100 crystal faces, with dimensions up to 300 μm, is evident in optimized films.
10 - 16 mu broad-band Quantum Well Infrared Photodetector (1998)

A broad-band infrared detector, sensitive over a 10 - 16 mu m spectral range, based on GaAs/A1xGa1-xAs quantum wells grown by molecular beam epitaxy, has been demonstrated.
A PCR-RFLP assay for the detection and differentiation of Campylobacter jejuni, C. coli, C. fetus, C. hyointestinalis, C. lari, C. helveticus and C. upsaliensis (2014)

Although Campylobacter jejuni and Campylobacter coli are the most common bacterial causes of human gastrointestinal diseases, other Campylobacter species are also involved in human and animal infections. In this study, we developed a cytolethal distending toxin (cdt) gene-based PCR-RFLP assay for the detection and differentiation of C. jejuni, C. coli, C. fetus, C. hyointestinalis, C. lari, C. helveticus and C. upsaliensis. Previously designed common primers, which can amplify the cdtB gene of C. jejuni, C. coli and C. fetus, were used for detecting seven Campylobacter species and differentiating between them by restriction digestion. The PCR-RFLP assay was validated with 277 strains, including 35 C. jejuni, 19 C. coli, 20 C. fetus, 24 C. hyointestinalis, 13 C. lari, 2 C. helveticus, 22 C. upsaliensis, 3 other Campylobacter spp. and 17 other species associated with human diseases. Sensitivity and specificity of the PCR-RFLP assay were 100 % except for C. hyointestinalis (88 % sensitivity). Furthermore, the PCR-RFLP assay successfully detected and differentiated C. jejuni, C. coli and C. fetus in clinical and animal samples. The results indicate that the PCR-RFLP assay is useful for the detection and differentiation of seven Campylobacter species important for human and animal diseases.
Specificity of regulatory T cells that modulate vascular inflammation (2014)

Intravenous immunoglobulin therapy (IVIG) is the treatment of choice for many immune-mediated diseases, yet its mechanisms of action are incompletely elucidated. We investigated the possibility that IVIG played a direct role in the expansion of regulatory T cells (Treg) that recognize the heavy chain constant region of immunoglobulin G (Fc) as a mechanism for the recovery of Kawasaki disease (KD), a T cell mediated pediatric vasculitis of the coronary arteries. We successfully generated Fc-specific Treg clones from sub-acute KD subjects that did not develop arterial complications after IVIG and defined an unusual functional phenotype: Fc-specific Treg secrete IL-10 and small amounts of IL-4 but not TGF-β. Antigen presentation studies demonstrated that these Treg clones can be activated by autologous B cells that express IgG on their cell surface in the absence of exogenous Fc. The IgG molecule has to be canonically processed and presented by autologous MHC molecules to be recognized by Treg. In support of the importance of this novel Treg population in downsizing vascular inflammation, KD patients with dilated coronary arteries or aneurysms despite IVIG treatment failed to expand Fc-specific Treg. Our results point to a specificity of a previously un-described Treg population for the clinical benefit provided by IVIG therapy in children.
Tracking of group‐housed pigs using multi‐ellipsoid expectation maximisation (2017)

Maintaining the health and well‐being of animals is critical to the efficiency and profitability of livestock operations. However, it can be difficult to monitor the health of animals in large group‐housed settings without the assistance of technology. This study presents a system that uses depth images to continuously track individual pigs in a group‐housed environment. It is an alternative to traditional manual observation used by both researchers and producers for the analysis of animal activities and behaviours. The tracking method used by the system exploits the consistent shape and fixed number of the targets in the environment by applying expectation maximisation as a policy for fitting an ellipsoid to each target. Results demonstrate that the system can maintain the correct positions and orientations of 15 group‐housed pigs for an average of 19.7 min between failure events.
Free-floating GPS sensor network for tsunami detection (2009)

Tsunamis can trigger atmospheric gravity waves (AGW) to induce electron density perturbation in the ionosphere. A complete model is proposed to simulate observable ionospheric response 20 minutes after a tsunami is generated. A novel approach is proposed to monitor the ionosphere above ocean in order to dectect possible tsunamis at early stage. A computerized tomography (CT) technique is used to generate a three-dimentional image of electron density perturbation in the ionosphere based on the total electron content (TEC) data measured at multiple GPS receivers. Simulation results show that by using this scheme, circular patterns of electron density perturbation in the ionosphere can be detected in less than half an hour from the outbreak of a tsunami.
Device For Sampling Surface Contamination (1995)

Specially designed cotton swab suitable for use in clean room. Contamination-sampling device improved version of basic cotton-tipped wooden applicator, designed for extreme cleanliness and to enhance utility for sampling according to exacting specifications. Device does not shed cotton and wood fibers.
Antigen-specific serotyping of Neisseria gonorrhoeae: characterization based upon principal outer membrane protein (1981)

Principal outer membrane protein (protein I) of Neisseria gonorrhoeae was prepared nearly free of lipopolysaccharide (LPS) and substantially purified from other membrane proteins by chromatography of partially purified gonococcal outer membranes over Sepharose 6B in the presence of deoxycholate at pH 9.0. This protein I of nine separate antigenic types was coated to polystyrene tubes and used in the enzyme-linked immunosorbent assay (ELISA) to measure antibody to protein I or in inhibition tests to quantitate protein I antigen. No significant inhibition of the ELISA test was produced by purified LPS from the strain used to prepare each of the protein I types or by whole gonococci bearing the same LPS but different protein I antigens as the strain used to produce a given protein I antigen. Of 125 strains of gonococci used as whole organisms to inhibit the protein I ELISA, 124 (99%) typed with one or more of the nine protein I types, and 35% of these typed with a single protein I serotype. Sixty-one of 65 (94%) strains from Seattle and Atlanta patients with disseminated gonococcal infection contained protein I serotype 1, and 16 of 24 (64%) strains from Seattle patients with salpingitis bore one or both of protein I serotypes 1 and 2.
Mining Audit Data for Intrusion Detection Systems Using Support Vector Machines and Neural Networks (2007)

This paper concerns using learning machines for intrusion detection. Two classes of learning machines are studied: Artificial Neural Networks (ANNs) and Support Vector Machines (SVMs). We show that SVMs are superior to ANNs for intrusion detection in three critical respects: SVMs train, and run, an order of magnitude faster; SVMs scale much better; and SVMs give higher classification accuracy. We also address the related issue of ranking the importance of input features, which is itself a problem of great interest in modeling. Since elimination of the insignificant and/or useless inputs leads to a simplification of the problem and possibly faster and more accurate detection, feature selection is very important in intrusion detection. Two methods for feature ranking are presented: the first one is independent of the modeling tool, while the second method is specific to SVMs. The two methods are applied to identify the important features in the 1999 DARPA intrusion data. It is shown that the two methods produce results that are largely consistent. We present various experimental results that indicate that SVM-based intrusion detection using a reduced number of features can deliver enhanced or comparable performance. An SVM-based IDS for class-specific detection is thereby proposed.
Synthesis of Nonfluorinated Amphiphilic Rod−Coil Block Copolymer and Its Application to Proton Exchange Membrane (2010)

New amphiphilic block copolymers composed of thermally and chemically stable poly(arylene sulfone ether ketone) and sulfonated poly(styrene-co-acrylonitrile) were successfully synthesized through two-step polymerization, condensation polymerization followed by controlled radical polymerization, for application to proton exchange membrane fuel cells. The morphological structures of membranes were investigated as functions of the hydrophilic chain length and the degree of sulfonation (DS), and were related to the proton conductivity of the membranes. Because of their inherent high thermal stability and well-connected hydrophilic channel, the newly synthesized membranes show high proton conductivity at relatively low DS and a continuous increase in proton conductivity above 90 °C. They also exhibit good thermal and oxidative stability.
Feasibility of a photoacoustic image guided telerobotic system for skull base surgery (2017)

This paper presents ongoing work to verify the feasibility of a photoacoustic image guided telerobotic system for skull base surgery via the endoscopic transnasal approach. A workspace analysis is conducted and used to design a realistic phantom that is scaled to match the dimensions of the testbed platform, which is based on a research da Vinci Surgical System.