gebhart/patrepeval huggingface dataset:
Distribution of exogenously added gangliosides in serum proteins depends on the relative affinity of albumin and lipoproteins. (1995)

Gangliosides in normal serum are found only in lipoproteins and the relative content of the three major lipoprotein fractions is low density lipoprotein > high density lipoprotein > very low density lipoprotein (LDL > HDL > VLDL). Upon in vitro incubation of labeled gangliosides with human serum, about 15% of the exogenous gangliosides became associated with the albumin fraction and 85% were distributed on the lipoproteins in the order HDL > LDL > VLDL. To compare the relative affinities of serum proteins for gangliosides, the levels of exchange of exogenous gangliosides between preloaded serum proteins were determined. Although albumin had the highest binding capacity for gangliosides, 85% of the albumin-loaded gangliosides were transferred to the total lipoprotein fraction and this exchange was reversible. The transfer rate from albumin to isolated lipoproteins was higher to LDL (90%) and HDL (85%) whereas only 55% of albumin-loaded gangliosides were transferred to VLDL. The study of exchanges of preloaded gangliosides between isolated lipoproteins showed that the extent of transfer of gangliosides from a given lipoprotein fraction onto other lipoproteins was inversely correlated with its endogenous ganglioside content. Moreover, in the absence of albumin from the incubation medium, the final lipoprotein distribution of remaining exogenous gangliosides was similar to the normal distribution of endogenous gangliosides in serum lipoproteins. The formation of unexchangeable complexes between albumin and micellar exogenous gangliosides could be a possible explanation for the observed differences in the distribution of exogenous and endogenous gangliosides in serum proteins.
High-Speed Data Serialization and Deserialization (840 Mb/s LVDS) (2002)

This application note addresses circuits capable of transferring up to 16 data channels at up to 840 Mb/s each for an aggregate data transfer per link of over 13 Gb/s. The design may be used multiple times in a Virtex™-II device. There is no limit to the number of transmitters (within pinning constraints) that can be used if they are using the same transmission clock. The Digital Clock Managers (DCMs) available to the designer, a maximum of 12 depending on device size, limit the number of receivers.
A Modified XPC Characterization for Polarimetric Channels (2011)

Models describing the polarimetric response of a multipath channel are considered. Conventional cross-polarization coupling (XPC) models are found to provide an ambiguous polarization representation and are sensitive to the receive antenna polarization configuration. These limitations are contrasted with polarization mode dispersion (PMD) models, which provide unambiguous frequency-dependent polarization characterizations. The XPC model is augmented using received signal power ratios associated with three orthogonally polarized antenna pairs. The revised model is shown to provide higher fidelity polarization characterizations. A comparison of the polarization behavioral models is illustrated using measured data from channel sounding experiments conducted in the 2.4-GHz industrial, scientific, and medical band in an urban propagation environment.
Removal of Ethylene and Secondary Organic Aerosols Using UV-C254 + 185 nm with TiO2 Catalyst (2013)

In this investigation we evaluated the feasibility and effectiveness of ozone-producing UV (254 + 185 nm) irradiation and a TiO2 photocatalyst for degradation of ethylene, which is strongly hydrophobic and does not decompose easily in a humid environment. Tests were performed in a photoreactor (V = 0.55 L) under UV irradiation at various wavelengths (365, 254 and 254 + 185 nm), relative humidities (RH < 1% and RH > 86%), atmospheres (pure N2 and air), residence times (11–33 sec), initial ethylene concentrations in the range of 25–105 ppmv and TiO2 contact areas (86.4–259 cm2) with presumably ambient pressure and temperature. The experimental results demonstrated that the use of TiO2 under 254 + 185 nm UV irradiation significantly enhanced the photodegradation of ethylene compared to the case of UV irradiation alone, due to the synergistic effect of photochemical oxidation in the gas phase and photocatalytic oxidation on the TiO2 surface. Photodegradation induced with 254 + 185 nm UV irradiation was compared with photodegradation induced with UV irradiation at wavelengths of 365 and 254 nm. The highest conversion and mineralization levels were obtained with 254 + 185 nm UV irradiation among the three tested UV sources. Moreover, irradiating with 254 +185 nm light generated secondary organic aerosols (SOA) via gas-to-particle conversion of organic compounds in the air stream. The results indicate that the concentration of generated SOAs decreased in the presence of the TiO2 catalyst, and thus that TiO2 may be used to effectively control the emissions of undesirable SOAs. In an application test, for photocatalytic oxidation with 254 + 185 nm UV irradiation, corresponding to a flow rate of 0.5 L/min, and an initial concentration of 34 ppmv, over 90% of the inlet ethylene could be degraded.
A novel class of hexanuclear titanoxanes: synthesis, structure and electronic configuration (1995)

Reduction of cyclopentadienyloxochloro complexes such as [R-cpTiCl(μ2-O)]4 (R = H (bd1), Me (bd2) or SiMe3 (bd3))) with a variety of reducing agents (Zn, Na, Mg or LiN3) in tetrahydroforum gave the hexanuclear titanoxanes [(R-cp)6Ti6O6Cl2] (RH (bd4), Me (5) or SiMe3 (6)) with a good yield. Complexes 4–6 are soluble in organic solvents, are diamagnetic and contain four electrons more than are required for the existence of the hexanuclear skeleton. Complex 4 was equally satisfactorily obtained by reducing R-cpTiCl2(μ2-O)] (RH) (7) will Bu3SnH. Reduction of 1 and 2 with Al powder gave [R-cp6Ti6O4Cl4] (RH (8) or Me (9)). They contain two unpaired electrons. Reaction of H2O with 4 and 5 gave the diamagnetic titanoxane [R-cp6Ti6 or Me (12)). Complexes 4–6, 8, 9, 11 and 12 all contain an octahedron of titanium atoms faced bridging oxygen and chlorine in the reported ration. Molecular orbital calculations showed that a band of 12 non-bonding orbitals may accomodate electrons in excess of those needed for the existence of the Ti6 skeleton and so the systems can be used in their intact form for storing and releasing electrons. The structures of complexes 4, 6, 9, and 12 were determined by single-crystal X-ray diffraction studies.
Randomised comparison of percutaneous endoscopic gastrostomy and nasogastric tube feeding in patients with persisting neurological dysphagia. (1992)

Percutaneous endoscopic gastrostomy tube feeding is a safe and effective method of providing long term enteral nutrition to patients with neurological dysphagia and offers important advantages over nasogastric tube feeding.
Third Eye: A Shopping Assistant for the Visually Impaired (2017)

Through a combination of wearable cameras, hardware accelerators, and algorithms, a vision-based automatic shopping assistant allows users with limited or no sight to select products from grocery shelves.
Characterization of the precursor of Serratia marcescens serine protease and COOH-terminal processing of the precursor during its excretion through the outer membrane of Escherichia coli (1989)

The Serratia marcescens serine protease, which is directed by the gene encoding a precursor composed of a typical NH2-terminal signal sequence, a mature enzyme domain, and a large COOH-terminal domain, was excreted through the outer membrane of Escherichia coli. The precursor, with the expected molecular size (110 kilodaltons), was detected in an insoluble form in the periplasmic space of E. coli cells after induction with isopropyl-beta-D-thiogalactopyranoside of the expression of the gene under the control of the tac promoter. Upon membrane fractionation of the disrupted cells by sucrose density gradient centrifugation, the precursor was recovered from a fraction slightly heavier than the outer membrane fraction but not from the inner membrane fraction. Conversion of the precursor into the mature form, which was accompanied by its excretion into the medium, was observed even in the absence of de novo protein synthesis caused by the addition of chloramphenicol. The mutated gene product lacking all of the COOH-terminal domain was localized in the periplasmic space only and was not excreted into the medium. Additional mutant genes were generated by site-directed mutagenesis to test the role of some amino acids in the excretion of this protease in E. coli. The mutant protein with no protease activity because of the change of the catalytic residue Ser-341 to Thr was still excreted into the medium but with abnormal processing. Both self-processing and host-dependent processing of the precursor seem to be involved in the excretion of the mature enzyme. Replacement of the four Cys residues, two in the mature enzyme and two in the COOH-terminal domain, with Ser in different combinations caused a distinct or complete loss of excretion, suggesting that a certain conformation possibly formed via disulfide bonding was important for the excretion of the S. marcescens protease.
Atomic Ordering Enhanced Electrocatalytic Activity of Nanoalloys for Oxygen Reduction Reaction (2013)

For oxygen reduction reaction (ORR) over alloy electrocatalysts, the understanding of how the atomic arrangement of the metal species in the nanocatalysts is responsible for the catalytic enhancement is challenging for achieving better design and tailoring of nanoalloy catalysts. This paper reports results of an investigation of the atomic structures and the electrocatalytic activities of ternary and binary nanoalloys, aiming at revealing a fundamental insight into the unique atomic-scale structure–electrocatalytic activity relationship. PtIrCo catalyst and its binary counterparts (PtCo and PtIr) are chosen as a model system for this study. The effect of thermochemical treatment temperature on the atomic-scale structure of the catalysts was examined as a useful probe to the structure–activity correlation. The structural characterization of the binary and ternary nanoalloy catalysts was performed by combining surface sensitive techniques such as XPS and 3D atomic ordering sensitive techniques such as high-energy X-ray diffraction (HE-XRD) coupled to atomic pair distribution function (PDF) analysis (HE-XRD/PDFs) and computer simulations. The results show that the thermal treatment temperature tunes the nanoalloy’s atomic and chemical ordering in a different way depending on the chemical composition, leading to differences in the nanoalloy’s mass and specific activities. A unique structural tunability of the atomic ordering in a platinum–iridium–cobalt nanoalloy has been revealed for enhancing greatly the electrocatalytic activity toward oxygen reduction reaction, which has significant implication for rational design and nanoengineering of advanced catalysts for electrochemical energy conversion and storage.
Retinoic Acid Induces Blood–Brain Barrier Development (2013)

The blood-brain barrier (BBB) is crucial in the maintenance of a controlled environment within the brain to safeguard optimal neuronal function. The endothelial cells (ECs) of the BBB possess specific properties that restrict the entry of cells and metabolites into the CNS. The specialized BBB endothelial phenotype is induced during neurovascular development by surrounding cells of the CNS. However, the molecular differentiation of the BBB endothelium remains poorly understood. Retinoic acid (RA) plays a crucial role in the brain during embryogenesis. Because radial glial cells supply the brain with RA during the developmental cascade and associate closely with the developing vasculature, we hypothesize that RA is important for the induction of BBB properties in brain ECs. Analysis of human postmortem fetal brain tissue shows that the enzyme mainly responsible for RA synthesis, retinaldehyde dehydrogenase, is expressed by radial glial cells. In addition, the most important receptor for RA-driven signaling in the CNS, RA-receptor β (RARβ), is markedly expressed by the developing brain vasculature. Our findings have been further corroborated by in vitro experiments showing RA- and RARβ-dependent induction of different aspects of the brain EC barrier. Finally, pharmacologic inhibition of RAR activation during the differentiation of the murine BBB resulted in the leakage of a fluorescent tracer as well as serum proteins into the developing brain and reduced the expression levels of important BBB determinants. Together, our results point to an important role for RA in the induction of the BBB during human and mouse development.
The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension (2018)

Increasing evidence points towards an inflammatory component underlying pulmonary hypertension. However, the conclusive characterisation of multiple inflammatory cell populations in the lung is challenging due to the complexity of marker specificity and tissue inaccessibility. We used an unbiased computational flow cytometry approach to delineate the inflammatory landscape of idiopathic pulmonary arterial hypertension (IPAH) and healthy donor lungs.Donor and IPAH samples were discriminated clearly using principal component analysis to reduce the multidimensional data obtained from single-cell flow cytometry analysis. In IPAH lungs, the predominant CD45<sup>+</sup> cell type switched from neutrophils to CD3<sup>+</sup> T-cells, with increases in CD4<sup>+</sup>, CD8<sup>+</sup> and γδT-cell subsets. Additionally, diversely activated classical myeloid-derived dendritic cells (CD14<sup>-</sup>HLA-DR<sup>+</sup>CD11c<sup>+</sup>CD1a<sup>+/-</sup>) and nonclassical plasmacytoid dendritic cells (pDCs; CD14<sup>-</sup>CD11c<sup>-</sup>CD123<sup>+</sup>HLA-DR<sup>+</sup>), together with mast cells and basophils, were more abundant in IPAH samples. We describe, for the first time, the presence and regulation of two cell types in IPAH, γδT-cells and pDCs, which link innate and adaptive immunity.With our high-throughput flow cytometry with multidimensional dataset analysis, we have revealed the interactive interplay between multiple inflammatory cells is a crucial part of their integrative network. The identification of γδT-cells and pDCs in this disease potentially provides a missing link between IPAH, autoimmunity and inflammation.
The Effect of Channelization on Floodplain Sediment Deposition and Subsidence Along the Pocomoke River, Maryland<sup>1</sup> (2010)

Kroes, Daniel E. and Cliff R. Hupp, 2010. The Effect of Channelization on Floodplain Sediment Deposition and Subsidence Along the Pocomoke River, Maryland. Journal of the American Water Resources Association (JAWRA) 46(4): 686‐699. DOI: 10.1111/j.1752‐1688.2010.00440.x Abstract: The nontidal Pocomoke River was intensively ditched and channelized by the mid‐1900s. In response to channelization; channel incision, head‐cut erosion, and spoil bank perforation have occurred in this previously nonalluvial system. Six sites were selected for study of floodplain sediment dynamics in relation to channel condition. Short‐ and long‐term sediment deposition/subsidence rates and composition were determined. Short‐term rates (four years) ranged from 0.6 to 3.6 mm/year. Long‐term rates (15‐100+ years) ranged from −11.9 to 1.7 mm/year. 137 Cs rates (43 years) indicate rates of 0.24 to 7.4 mm/year depending on channel condition. Channelization has limited contact between streamflow and the floodplain, resulting in little or no sediment retention in channelized reaches. Along unchannelized reaches, extended contact and depth of river water on the floodplain resulted in high deposition rates. Drainage of floodplains exposed organic sediments to oxygen resulting in subsidence and releasing stored carbon. Channelization increased sediment deposition in downstream reaches relative to the presettlement system. The sediment storage function of this river has been dramatically altered by channelization. Results indicate that perforation of spoil banks along channelized reaches may help to alleviate some of these issues.
Automatic WLAN localization for industrial automation (2008)

The increasing WLAN deployment in industrial environments opens possibilities for location based services such as asset-tracking and workflow optimization. This paper presents our current research to develop a WLAN-localization system that fulfils the requirements of industrial automation: scalability and 5-10 m localization accuracy. Our envisaged system produces the training data automatically using automatic measurements, and model calibration. The suggested approach avoids the effort for walk-around and extensive manual measurements and is stable under environmental changes, while still achieving an accuracy equivalent to state-of-the art technology. Preliminary evaluation shows an average accuracy of 3.7 m (12ft).
A Prospective, Randomized Trial of Tacrolimus in Combination with Sirolimus or Mycophenolate Mofetil in Kidney Transplantation: Results at 1 Year (2005)

Tacrolimus is safe and effective in live and deceased donor kidney transplantation when given in combination with sirolimus or MMF. Patient and graft survival were excellent in both arms. Renal function is superior for patients treated with tacrolimus + MMF combination.
Nonlinear Stability Theorem of Zonally Symmetric Quasi-Geostrophic Flow (2003)

Nonlinear stability theorem analogous to Arnold's second stability theorem is established for a quasi-geostrophic flow with general boundary conditions in a periodic channel. The results establish explicit upper bounds on the disturbance energy, the disturbance potential enstrophy, in terms of the initial disturbance fields. Nonlinear stability in the sense of Liapunov is also established.
On the Object-Oriented Modelling of Distributed Workflow Applications (1997)

Viele Geschäftsprozesse beinhalten Folgen von wiederkehrenden Arbeitsschritten, die sich als Workflows strukturieren lassen. Sowohl in lokalen als auch in verteilten Systemen wird das Objektmodell als Grundlage zur Analyse, Modellierung und Implementation großer Anwendungssysteme herangezogen. Wenngleich Objektmodell, Verteilte Systeme und Workflows für sich genommen bereits weitestgehend analysiert und verstanden sind, so ergeben sich für deren Kombination eine Reihe offener Fragen. Wir diskutieren diese Fragen und präsentieren unsere Lösung zur Modellierung und Implementierung verteilter Workflow-Anwendungen gemäß des Objektmodells. Sie vereinigt die Möglichkeiten und Vorteile von Workflow-Modellen und objektorientierter Softwareentwicklung.
Building cell-containing multilayered phospholipid polymer hydrogels for controlling the diffusion of a bioactive reagent (2015)

We developed multilayered phospholipid polymer hydrogels containing living cells and a specific bioactive reagent for the regulation of cell-fate.
Necesidades formativas del profesorado para la educación inclusiva intercultural (2011)

Presentamos parte de un proyecto de investigacion sobre recursos y estrategias pedagogicas para la transformacion de las escuelas desde un enfoque inclusivo intercultural. El profesorado es un elemento clave en el inicio y desarrollo de este proceso de cambio, por lo que su desarrollo profesional debe partir de la deteccion de sus propias necesidades formativas. El estudio, a partir de un grupo de discusion amplio, recoge las percepciones de un grupo de profesorado de Infantil, Primaria y Secundaria de diferentes materias. Los resultados apuntan que es en el aula donde se inicia el verdadero cambio y precisamente en este marco de accion docente mas inmediato se focalizan las demandas. Se presentan propuestas de formacion acordes a las conclusiones del estudio
Optimization of Composting for Explosives Contaminated Soil (1991)

Abstract : A composting optimization field study for explosives contaminated soil was conducted at the Umatilla Army Depot Activity (UMDA) in order to maximize the quantity of soil treated per unit time. Different amendments and soil loading levels were investigated in mechanically agitated and static pile reactors. In addition to the removal of TNT, RDX, and HMX, compost moisture, temperature, and pH were monitored. Toxicity reduction was monitored, using the same samples analyzed by WESTON, at Oak Ridge National Laboratory. All three explosives were significantly degraded. Degradation dropped as soil loading increased from 30 to 40 volume percent in each reactor type. More effective degradation was achieved in the mechanically agitated reactor than in the static pile reactors. Amendment composition affected degradation rate and extent, as well as operating parameters such as pH.
An automated testing methodology based on self-checking software (2002)

New techniques are required to speed the software testing process and to enhance the ultimate reliability of mission-critical embedded information systems. Here we employ result-checking, a technique in which software assures the correctness of its own computations through efficient: run-time checks. Building on previous work at U.C. Berkeley and Raytheon Systems Company, the Air Force Research Laboratory is funding the Automated Generation of Avionics Software Tests (AGAST) program to demonstrate that result-checking can be the basis for a flexible new methodology of software testing. This methodology aims at the production of software which has an enhanced sensitivity to its own errors (complemented with appropriate instrumentation), and which therefore may be tested with extremely high efficiency and accuracy.
Biological effect of an alternating electric field on cell proliferation and synergistic antimitotic effect in combination with ionizing radiation (2016)

Alternating electric fields at an intermediate frequency (100~300 kHz), referred to as tumour-treating fields (TTF), are believed to interrupt the process of mitosis via apoptosis and to act as an inhibitor of cell proliferation. Although the existence of an antimitotic effect of TTF is widely known, the proposed apoptotic mechanism of TTF on cell function and the efficacy of TTF are controversial issues among medical experts. To resolve these controversial issues, a better understanding of the underlying molecular mechanisms of TTF on cell function and the differences between the effects of TTF alone and in combination with other treatment techniques is essential. Here, we report experimental evidence of TTF-induced apoptosis and the synergistic antimitotic effect of TTF in combination with ionizing radiation (IR). For these experiments, two human Glioblastoma multiforme (GBM) cells (U373 and U87) were treated either with TTF alone or with TTF followed by ionizing radiation (IR). Cell apoptosis, DNA damage, and mitotic abnormalities were quantified after the application of TTF, and their percentages were markedly increased when TTF was combined with IR. Our experimental results also suggested that TTF combined with IR synergistically suppressed both cell migration and invasion, based on the inhibition of MMP-9 and vimentin.