gebhart/patrepeval huggingface dataset:
Molecular dynamics simulations of the structure and dynamics of confined polymer melts (1990)

We performed a series of molecular dynamics simulations investigating the static and dynamic properties of polymer melts confined between planar solid surfaces. The solid–melt interface was found to be very narrow (approximately two segment diameters) and independent of chain length. Inside the interface the segment density profile was oscillatory, the bond orientation altered between directions parallel and normal to the solid surface, and the chain ends accumulated very close to the wall (in the absence of strong wall–segment attraction). The oscillations of the segment density profile were weaker and were dampened faster than those of a simple fluid density profile next to the same solid surface. This reflected the reduced ability of sequences of connected segments (chains) to layer themselves against a solid surface because of restrictions on their configurations imposed by the chain connectivity requirement. This effect made the solid–melt interface even narrower than that of a simple fluid. Only the chain portions lying inside the interface had their shape affected by the wall. Chain statistical segments inside the interface assumed orientations parallel to the wall. In the absence of wall–segment attraction, the size of the statistical segments inside the interface was unaffected. This situation resulted in an apparent decrease of the radius of gyration normal to the wall an apparent increase of the radius of gyration parallel to the wall and spatial independence of the total radius of gyration. The wall effect was gradually diminished and chains assumed their bulk dimensions when their center-of-mass was so far from the solid surface that no portions of the chain could reach the interface (i.e., at a distance comparable to the bulk radius of gyration). The microscopic dynamics of chain portions inside the interface were strongly anisotropic. The mobility increased in the direction parallel to the wall and decreased normal to the wall. This fact was caused by the angular asymmetry of the segment–segment collisions inside the interface, i.e., by the same mechanism that induces the segment layering. The total mobility inside the neutral wall–melt interface was identical with that in the bulk reflecting the fact that the average segment density inside the interface had essentially the bulk value. The presence of strong wall–segment attraction increased the average interfacial density above the bulk value and lowered the mobility of the interfacial chain portions in all directions. The mean-square displacement of the chain center-of-mass during a certain time interval was affected by the solid only if the chain had a portion of itself inside the interface for a fraction of this time interval. The longest relaxation time of the chains, a property that cannnot be localized properly on a length scale smaller than the interfacial width, exhibited a weak and strongly diminishing with chain length spatial dependence.
Mapping the Encapsidation Determinants of Feline Immunodeficiency Virus (2002)

Encapsidation of retroviral RNA involves specific interactions between viral proteins and cis-acting genomic RNA sequences. Human immunodeficiency virus type 1 (HIV-1) RNA encapsidation determinants appear to be more complex and dispersed than those of murine retroviruses. Feline lentiviral (feline immunodeficiency virus [FIV]) encapsidation has not been studied. To gain comparative insight into lentiviral encapsidation and to optimize FIV-based vectors, we used RNase protection assays of cellular and virion RNAs to determine packaging efficiencies of FIV deletion mutants, and we studied replicative phenotypes of mutant viruses. Unlike the case for other mammalian retroviruses, the sequences between the major splice donor (MSD) and the start codon of gag contribute negligibly to FIV encapsidation. Moreover, molecular clones having deletions in this region were replication competent. In contrast, sequences upstream of the MSD were important for encapsidation, and deletion of the U5 element markedly reduced genomic RNA packaging. The contribution of gag sequences to packaging was systematically investigated with subgenomic FIV vectors containing variable portions of the gag open reading frame, with all virion proteins supplied in trans. When no gag sequence was present, packaging was abolished and marker gene transduction was absent. Inclusion of the first 144 nucleotides (nt) of gag increased vector encapsidation to detectable levels, while inclusion of the first 311 nt increased it to nearly wild-type levels and resulted in high-titer FIV vectors. However, the identified proximal gag sequence is necessary but not sufficient, since viral mRNAs that contain all coding regions, with or without as much as 119 nt of adjacent upstream 5' leader, were excluded from encapsidation. The results identify a mechanism whereby FIV can encapsidate its genomic mRNA in preference to subgenomic mRNAs.
Texture overlay onto deformable surface using HMD (2004)

We propose a system that overlays textures onto the deformable surface of an object in real time using HMD. We assume that the surface projected onto an HMD image consists of curved surfaces which can be approximated by 2D geometric curved surface, so that we can deform textures using the matrix of 2D geometric transformation and the deformed textures are overlaid onto the HMD image. The system computes the transformation matrix in each frame, the textures are overlaid in real time even if an observer with HMD moves or deforms the surface. In the system, we select a book as the object with deformable shape and documents as the textures. Therefore, the observer can read digitized documents as if he reads real books.
A Robust Procedure For Gaussian Graphical Model Search From Microarray Data With p Larger Than n (2006)

Learning of large--scale networks of interactions from microarray data is an important and challenging problem in bioinformatics. A widely used approach is to assume that the available data constitute a random sample from a multivariate distribution belonging to a Gaussian graphical model. As a consequence, the prime objects of inference are full--order partial correlations which are partial correlations between two variables given the remaining ones. \nIn the context of microarray data the number of variables exceed the sample size and this precludes the application of traditional\nstructure learning procedures because a sampling version of\nfull--order partial correlations does not exist. In this paper we\nconsider limited--order partial correlations, these are\npartial correlations computed on marginal distributions of\nmanageable size, and provide a set of rules that allow one to assess the usefulness of these quantities to derive the independence structure of the underlying Gaussian graphical model. Furthermore, we introduce a novel structure learning procedure based on a quantity, obtained from limited--order partial correlations, that we call the non--rejection rate. The applicability and usefulness of the procedure are demonstrated by both simulated and real data.
An Array of Microactuated Microelectrodes for Monitoring Single-Neuronal Activity in Rodents (2005)

Arrays of microelectrodes used for monitoring single- and multi-neuronal action potentials often fail to record from the same population of neurons over a period of time for several technical and biological reasons. We report here a novel Neural Probe chip with a 3-channel microactuated microelectrode array that will enable precise repositioning of the individual microelectrodes within the brain tissue after implantation. Thermal microactuators and associated microelectrodes in the Neural Probe chip are microfabricated using the Sandia's Ultraplanar Multi-level MEMS Technology (SUMMiTV) process, a 5-layer polysilicon micromachining technology of the Sandia National labs, Albuquerque, NM. The Neural Probe chip enables precise bi-directional positioning of the microelectrodes in the brain with a step resolution in the order of 8.8 microm. The thermal microactuators allow for a linear translation of the microelectrodes of up to 5 mm in either direction making it suitable for positioning microelectrodes in deep structures of a rodent brain. The overall translation in either direction was reduced to approximately 2 mm after insulation of the microelectrodes with epoxy for monitoring multi-unit activity. Single unit recordings were obtained from the somatosensory cortex of adult rats over a period of three days demonstrating the feasibility of this technology. Further optimization of the microelectrode insulation and chip packaging will be necessary before this technology can be validated in chronic experiments.
High‐resolution analysis of the murine MHC class II immunopeptidome (2015)

The reliable identification of peptides bound to major histocompatibility complex (MHC) class II is fundamental for the study of the host immune response against pathogens and the pathogenesis of autoimmune conditions. Here, we describe an improved methodology combining immuno-affinity enrichment of MHC class II complexes, optimized elution conditions and quadrupole Orbitrap mass spectrometry-based characterization of the immunopeptidome. The methodology allowed the identification of over 1000 peptides with 1% false discovery rate from 10(8) murine A20 lymphoma cells. The study revealed the I-A(d) -specific motif in high resolution after multisequence alignment. The methodology was generally applied to the purification of MHC class II from cell lines and murine spleens. We identified 2963 peptides from BALB/c and 2712 from C57BL/6 mouse spleens. The identification of peptides bound to MHC class II in vitro and in vivo will facilitate the characterization of T-cell specificities, as well as the development of biotherapeutics and vaccines.
Using Linguistic Cues for the Automatic Recognition of Personality in Conversation and Text (2007)

It is well known that utterances convey a great deal of information about the speaker in addition to their semantic content. One such type of information consists of cues to the speaker's personality traits, the most fundamental dimension of variation between humans. Recent work explores the automatic detection of other types of pragmatic variation in text and conversation, such as emotion, deception, speaker charisma, dominance, point of view, subjectivity, opinion and sentiment. Personality affects these other aspects of linguistic production, and thus personality recognition may be useful for these tasks, in addition to many other potential applications. However, to date, there is little work on the automatic recognition of personality traits. This article reports experimental results for recognition of all Big Five personality traits, in both conversation and text, utilising both self and observer ratings of personality. While other work reports classification results, we experiment with classification, regression and ranking models. For each model, we analyse the effect of different feature sets on accuracy. Results show that for some traits, any type of statistical model performs significantly better than the baseline, but ranking models perform best overall. We also present an experiment suggesting that ranking models are more accurate than multi-class classifiers for modelling personality. In addition, recognition models trained on observed personality perform better than models trained using self-reports, and the optimal feature set depends on the personality trait. A qualitative analysis of the learned models confirms previous findings linking language and personality, while revealing many new linguistic markers.
Strong reflection of a series of pulses from a four-wave mirror with thermal nonlinearity under parametric feedback conditions (1989)

A four-wave mirror exhibiting a thermal nonlinearity was used in a study of the interaction of concurrent waves under parametric feedback conditions in the presence of a nonreciprocal element. Strong reflection of a series of pulses of ~ 300 ns duration from a neodymium glass laser was demonstrated: the maximum reflection coefficient was in excess of 30. An analysis was made of the quality of the radiation reflected from this four-mirror parametric feedback system. A considerable reduction was observed in the steady-state threshold for the operation of this mirror with a thermal nonlinearity when the angles of convergence of the interacting beams were small compared with the case of head-on collision of the waves.
Comparison of consumers’ acceptance of online apparel mass customization across web and mobile channels (2019)

The purpose of this study is to shed light on understanding consumer apparel mass customization experiences through an experiment focusing on comparing customers’ experiences across different online channels. Applying the Technology Acceptance Model, we systematically examined how favorable attitudes were influenced across web and mobile channels. Structural equation modeling, multiple group comparison, and MANOVA were conducted to assess construct validity, and test the proposed framework and hypotheses, respectively. An online survey experiment was designed to collect empirical data. A total of 388 college students from a major university in the United States participated in the study. Based on consumers’ real experience, research results showed that beliefs about ease of use, enjoyment, choice variety, and not usefulness or risk affect attitudes, and acceptance of OAMC via both web and mobile channels. Overall consumers favor web channels more than mobile channels and were more likely to get OAMC through websites over retail apps. Theoretical and practical implications were provided based on research findings.
Role of Surveillance in Improving Subsea Productivity (2004)

Abstract A number of industry sources have identified the need to improve overall productivity of subsea wells through the application of monitoring and control systems in the wellbore and on the seabed. To achieve this goal, two elements must be mastered: information and measurements of key attributes of the well/reservoir productivity, and a means to change and command the process, preferably through remote-controlled devices rather than traditional well intervention. With the advent of intelligent wells, the second element has been addressed through a variety of process control devices used at different points in the wellbore and on the seabed. However, the growth of this process was limited by the absence of effective information gathering and data transmission systems in subsea wells, which remained underdeveloped compared to other subsea hardware. This resulted in systematic information bottlenecking caused by poor connectivity between the wellbore and the rest of the subsea infrastructure. The paper introduces a complementary surveillance system that works with existing subsea devices and highlights its role in gathering and transmitting well and subsea data reliably and in sufficient time needed to maintain optimal production. In particular, the system targets high data traffic areas in order to de-bottleneck the subsea transmission systems and provides wellbore monitoring and inflow quantification. A continuous data highway is now available to both wellbore and subsea-based measurements, leading to improved monitoring and control of the entire subsea system. The applications and benefits of the system are demonstrated through a case study. The study discusses the role of the surveillance system in bringing the productivity index of subsea wells to be in par with the platform wells. It also demonstrates the need to rethink the flow assurance process as increasing number of distributed seabed measurements become available to the subsea industry and tie-back distances increase to make the best use of expensive host facilities.
Activity of the mitochondrial metabolism inhibitor cpi-613 in combination with high dose Ara-C (HDAC) and mitoxantrone in high risk relapsed or refractory acute myeloid leukemia (AML). (2015)

7015 Background: CPI-613 is a novel agent that targets mitochondrial metabolism. It inhibits mitochondrial respiration in AML cells and in a single agent phase I study was active for several patients with myeloid malignancies.This trial was designed to determine the maximum tolerated dose (MTD) and efficacy of CPI-613 in combination with HDAC and mitoxantrone in relapsed or refractory AML. Methods: CPI-613 was given daily on days 1 through 5 starting at a dose of 500 mg/m2. Beginning on day 3, HDAC (3,000 mg/m2 or 1,500 mg/m2 for age ≥ 60) was given every 12 hours for 5 doses and mitoxantrone at 6 mg/m2 was given daily for 3 doses. If residual disease was present on day 14, a second cycle could be given. Patients who achieved a complete remission with or without complete count recovery (CR or CRi) could receive additional cycles with the goal of stem cell transplantation when possible. Results: A total of 48 patients are evaluable. The median age is 60 (range 21-79). Fourteen patients had refractory disease and 11 received one or more previous lines of salvage therapy. Cytogenetics were poor risk in 23, intermediate in 20, good in 4 and one patient had CML blast crisis. The overall response rate was 48% (19CR+4CRi). Three of five patients with FLT3 mutations achieved a CR/CRi (60%). Patients age ≥ 60 had a CR/CRi rate of 46% (12/26). Surprisingly, patients with poor-risk cytogenetics had a CR/CRi rate of 48% (11/23). In a historical cohort of poor-risk patients treated with HDAC, mitoxantrone and asparaginase, only 25% responded. Median survival for the entire cohort is 6.4 months. Six patients (12.5%) died on or before day 30. The CPI-613 dose has been escalated to 2750 mg/m2 with the MTD not yet determined. Stem cell transplantation was performed on 23% (11/48) of patients. Samples from patients before and after CPI-613 showed induction of phosphorylation of the E1α subunit of pyruvate dehydrogenase and AMPK consistent with the proposed mechanism of action. Conclusions: CPI-613 in combination with HiDAC and mitoxantrone is a promising salvage regimen and these data support additional studies especially in older patients and those with high-risk disease. Clinical trial information: NCT01768897.
A homogeneous heating technique in preform manufacturing (1986)

A new heating technique in preform manufacturing, which enables a faster collapse and a larger preform size, has been developed. On an ordinary MCVD preform station, the torch has been replaced by a microwave (dielectric) heater. With this equipment both deposition and collapse of thick-walled tubes have been performed. Preforms, of single-mode design and with an outer diameter of 35 mm, have been fabricated. This preform size corresponds to 40 km of fiber per half meter preform.
A phase I clinical tolerance study of polyadenylic-polyuridylic acid in cancer patients. (1985)

Polyadenylic-polyuridylic acid [poly(A) X poly(U)], an immunomodulator, has been shown to have antitumor effects in rodents and in a randomized clinical trial as an adjuvant to surgery in patients with operable breast cancer. The purpose of the present study was to determine the following: (a) clinical tolerance and safety of poly(A) X poly(U) in 13 patients with advanced cancer receiving a single dose of this duplex, using increasing amounts per intravenous injection of 90, 180, 300, and 450 mg; (b) if such high doses increased the level of interferon-mediated protein kinase and enhanced natural killer (NK) cell activity as observed previously with lower doses; and (c) if circulating interferon could be detected. No toxicity was observed in the 13 patients by close observation of clinical parameters, hemogram, and renal and liver functions. Increases of interferon-mediated protein kinase and of NK cell activity were observed, but there was no correlation between the magnitude of the responses and the dose of poly(A) X poly(U). No circulating interferon was detected. We conclude that poly(A) X poly(U) is not toxic in humans, at least up to a dose of 450 mg.
Characteristics of Ti-Capped Co Films Deposited by a Remote Plasma ALD Method Using Cyclopentadienylcobalt Dicarbonyl (2007)

films were deposited by a remote plasma atomic layer deposition (RPALD) method using cyclopentadienylcobalt dicarbonyl as the precursor with plasma. The impurity contents in the films were minimized under the optimized process conditions with plasma using a process pressure range between 0.1 and and a plasma power of . The ALD process window of the films showed a saturated temperature range between 125 and . The carbon and oxygen contents of as-deposited films were about 8 and 1 atom %, respectively. However, the carbon content in the films decreased from 8 to 4 atom % after in situ annealing at . For in situ annealed films deposited on substrates, a polycrystalline phase was observed. The surface and interface morphologies of were rough compared to -capped after ex situ annealing at . In addition, was completely transformed to at . However, in the in situ annealed films with -capped layer, the diffraction peak of began to appear at . The formation temperature of the -capped phase was retarded by about compared to the film without the -capped layer. In addition, the surface and interface morphologies of the -capped layer were smooth.
기업의 무형식 학습이 비재무적 성과를 매개로 재무적 성과에 미치는 영향 (2012)

본 연구는 무형식 학습의 실시 정도에 따른 기업의 비재무적 성과와 재무적 성과의 차이를 알아보고, 무형식 학습 실시 정도와 재무적 성과의 관계에서 비재무적 성과의 매개효과를 살펴보고자 하였다. 이를 위해 한국직업능력개발원의 2009년 인적자본기업패널(Human Capital Corporate Panel, HCCP) 자료 중 386개 기업 자료와 4,797명의 근로자 자료를 활용하였다. 분석은 무형식 학습의 실시정도에 따른 비재무적 성과와 재무적 성과의 차이를 살펴보기 위해 일원분산분석(one-way ANOVA)과 Dunnett 사후검증을 실시하였고, 매개효과를 분석하기 위해서 Baron과 Kenny의 회귀분석 및 sobel test를 실시하였다. 분석 결과 다양한 무형식 학습을 실시하는 기업일수록 비재무적 성과와 재무적 성과가 높은 것으로 나타났고, 비재무적 성과는 무형식 학습 실시와 재무적 성과간의 관계에서 매개 역할을 수행하는 것으로 나타났다. 이 연구의 결과는 기업의 성과 향상을 위한 무형식 학습의 중요성과 필요성을 보여주었고, 기업에서 무형식 학습의 활성화를 위해 노력할 필요가 있음을 시사하고 있다.