gebhart/patrepeval huggingface dataset:
A time-series approach for shock outcome prediction using machine learning (2010)

Chances of successful defibrillation, and that of subsequent return of spontaneous circulation (ROSC), worsen rapidly with passage of time during cardiac arrest. The Electrocardiogram (ECG) signal of ventricular fibrillation (VF) has been analyzed for certain characteristics which may be predictive of successful defibrillation. Time-series features were extracted. A total of 59 counter shocks (CS) were analyzed. They were best classified as successful or unsuccessful by employing the Random Tree method. An average accuracy of 71% was achieved for 6 randomized runs of 6-fold cross validation. Classification could be performed on ECG tracings of 40 seconds. Real-time, short-term analysis of ECG, through signal-processing and machine-learning techniques, may be valuable in determining CS success.
Searching the searchers with searchaudit (2010)

Search engines not only assist normal users, but also provide information that hackers and other malicious entities can exploit in their nefarious activities. With carefully crafted search queries, attackers can gather information such as email addresses and misconfigured or even vulnerable servers. We present SearchAudit, a framework that identifies malicious queries from massive search engine logs in order to uncover their relationship with potential attacks. SearchAudit takes in a small set of malicious queries as seed, expands the set using search logs, and generates regular expressions for detecting new malicious queries. For instance, we show that, relying on just 500 malicious queries as seed, SearchAudit discovers an additional 4 million distinct malicious queries and thousands of vulnerable Web sites. In addition, SearchAudit reveals a series of phishing attacks from more than 400 phishing domains that compromised a large number of Windows Live Messenger user credentials. Thus, we believe that SearchAudit can serve as a useful tool for identifying and preventing a wide class of attacks in their early phases. 1
Short-term regulation of insulin gene transcription (2001)

Short-term regulation of insulin gene transcription is still a matter of debate. However, an increasing body of evidence shows that insulin gene transcription is affected by signals, such as incretins, glucose metabolites, intracellular Ca2+, and by insulin secreted from pancreatic β-cells, all supporting the concept of an immediate response resulting in insulin gene transcription following food-uptake. The present review aims to summarize the current view on the mechanisms underlying the up-regulation of insulin gene transcription in response to glucose, the major nutrient factor in insulin secretion and biosynthesis.
Nonlinear Optical Crystal Y<i><sub>x</sub></i>La<i><sub>y</sub></i>Sc<i><sub>z</sub></i>(BO<sub>3</sub>)<sub>4</sub> (<i>x</i> + <i>y</i> + <i>z</i> = 4) (2005)

The new nonlinear optical crystal YxLayScz(BO3)4 (x + y + z = 4) has been discovered. Phase boundaries have been established in the determination of the x, y, z composition parameters that define the existence region of the trigonal huntite-type structure. From single-crystal X-ray diffraction measurements, the member Y0.57La0.72Sc2.71(BO3)4 has been found to crystallize in space group R32 with cell dimensions a = 9.774(1) and c = 7.944(3) Å. Large single crystals have been grown by a high-temperature solution method. The high-energy optical absorption edge for polished pieces was found to be at a wavelength shorter than 200 nm. Sellmeier equations for the dispersion in the refractive indices were determined on the basis of curve fitting of data obtained by the method of minimum deviation. From modeling and optical measurements on powders, the nonlinear optical coefficient d11 has been determined to be 1.4 pm/V.
Direct methanol oxidation at low overpotentials using Pt nanoparticles electrodeposited at ultrathin conductive RuO2 nanoskins (2012)

Small (primarily 2–4 nm) Pt nanoparticles electrodeposited at Ti-supported RuO2 nanoskins, designated as Pt/RuO2(Ti), are highly active for electrocatalytic oxidation of methanol (CH3OH) in acid electrolyte, with peak potentials among the lowest reported anywhere for RuO2-supported Pt. The Pt-modified RuO2 nanoskin is equally effective for CH3OH oxidation whether one or both sides of the Ti-foil substrate is coated or whether the RuO2 nanoskin is electrolessly deposited at the Ti substrate as a single layer or in multiple layers. Current densities for methanol oxidation are ∼2× lower than previously reported, owing to a bimodal distribution of both highly active (2–4 nm) and less active larger (> 5 nm) Pt particles. The methods reported here comprise a means of expressing highly active, nanostructured, bifunctional electrocatalytic coatings on substrates of essentially any geometry and minimizing the quantity of RuO2 necessary.
Low-cost device for ratiometric fluorescence measurements (1999)

An all-solid-state, low-cost device for fluorescent wavelength-ratiometric detection is described. Ultrabright light-emitting diodes were used as light sources. This allowed electronic modulation of the light, simple optical configuration, and miniaturization of the instrument. Narrow-bandpass interference filters were used for wavelength separation. Detection was accomplished by high-sensitivity, large-surface PIN photodiodes. An integrating double-ramp technique with fixed upper and lower thresholds was employed for conversion of the light intensities into time intervals. The duty ratio of the output signal was a function of the fluorescence intensity ratio. Additionally, the concentration of the fluorophore could be measured. The device could be easily designed as a battery-operated version. It could be used for a variety of ratiometric fluorescence measurements.
Tensiometer-irrigation Control Valve (1993)

A simple, irrigation control valve was developed that mechanically links the soil water potential, expressed through negative pressure developed in a tensiometer, to the position of a piston that controls the flow of water through the valve. No external power was required. Initial irrigation level was controllable [starting at 23 kPa (3 psi) tensiometer pressure] and flow increased as tensiometer pressure decreased due to soil dryness. Testing showed the valve to be reliable and operation repeatable.
Generalized wavefront reconstruction algorithm for slope data: Iterative linear equation approach (2003)

Reconstructing wavefront from slope data is a basic technique in optical testing and in media turbulence characterization. A popular approach today is to reconstruct the wavefront from slope data based on the linear least squares method. A frequent problem encountered in practice is the need to establish a different reconstruction matrix for each pupil shape under test, and setting up a reconstruction matrix maybe laborious and time-consuming. In 2000[1], Zou proposed a generalized algorithm based on linear least-squares method, which can be applied for irregular-shape pupils. This algorithm is efficient, but the wavefront reconstructed with this algorithm leads to more than 4-λ deviation errors (peak-to-valley) from the original. Now we propose a iterative process to reduce this deviation errors.
Laterally oxidized vertical-cavity lasers with stable polarization (1999)

We disclose a method of eliminating the polarization instability in laterally-oxidized vertical-cavity surface- emitting lasers. By employing an appropriately-shaped device aperture, we are able to make the lasers operate in a single polarization direction through their entire L-I curve.
Fluorescent‐conjugated antibodies as rapid ex vivo markers for bacterial presence on orthopedic surgical explants and synovium: A pilot study (2020)

Surgical infection is one of the most pressing problems in the field of orthopedic surgery; however, current detection methods are plagued by high costs and long wait times. This study seeks to demonstrate the ability of a novel assay using fluorescently conjugated antibodies and confocal laser scanning microscopy (CLSM) to accurately detect bacterial presence on orthopedic surgical explants, tissue, and synovial fluid in 30 min. Explanted hardware, tissue, and synovial fluid samples suspected to be infected were collected from human subjects with institutional review board consent. Samples were prepared using a 30-min protocol, consisting of rinsing, nonspecific blocking and staining steps, and imaged using CLSM. Images were analyzed using ImageJ (National Institute of Health) to determine the percent area of Gram positive and Gram negative bacteria. Results of the assay were compared to the hospital's microbiological laboratory and Gram staining results. Ninety three samples were collected and tested using the 30-min testing protocol; 75 samples were synovial fluid and 18 were tissue and explants. Seventy four of 75 (98.6%) synovial fluid samples correlated with the hospital laboratory's microbiological findings. Of the 18 explant and tissue samples, our assay found bacterial presence in 14 of 18 samples, while the hospital microbiology laboratory found bacterial presence in 13 of 18 samples. This assay reliably stained and rapidly identified the presence of Gram negative and Gram positive bacteria on surgical explants, tissue and synovial fluid in 30 min. This methodology may serve as a point of service tool for the determination of bacterial presence during surgical procedures.
Effects of L-carnitine on performance of gestating and lactating sows (1997)

A total of 307 sows was used to determine the effects of adding 50 ppm of L-carnitine in gestation and lactation diets on sow and litter performance. Addition of 50 ppm L-carnitine in gestation increased both total litter (34.1 vs 32.1 lb) and pig (3.48 vs 3.27 lb) birth weight. Litter weaning weights increased (99.03 vs 90.71 lb) when sows were fed added L-carnitine during gestation. Sows fed added L-carnitine in gestation had increased IGF-I concentrations on d 60 and 90 (71.3 vs 38.0, and 33.0 vs 25.0 ng/ml, respectively). These results suggest that feeding 50 ppm of added L-carnitine during gestation increases litter birth and weaning weights.; Swine Day, Manhattan, KS, November 20, 1997
Design of potent antagonists of the vasopressor response to arginine-vasopressin (1978)

As part of a program in which we are attempting to design and synthesize antagonists of the vasopressor response to arginine-vasopressin (AVP), [1-deaminopenicillamine]arginine-vasopressin (dPAVP), [2-O-methyl)tyrosine]-arginine-vasopressin [Tyr(Me)AVP], and [1-deaminopenicillamine,2-(O-methyl)tyrosine]arginine-vasopressin [dPTyr(Me)AVP] were synthesized by the solid-phase method and assayed for vasopressor, antidiuretic, and oxytocic activities. Tyr(Me)AVP has a vasopressor potency of 9.7 +/- 0.5 units/mg and an antidiuretic potency of 386 +/- 36 units/mg. These values are 2.5 and 120%, respectively, of the corresponding potencies of AVP. The analogue is an antagonist of the in vitro response to oxytocin (pA2 = 7.44 +/- 0.12). dPAVP has an antivasopressor pA2 of 7.45 +/- 0.11. Its antidiuretic potency is 42.2 +/- 2 units/mg, 2.5% that of its parent, 1-[deamino]arginine-vasopressin (dAVP). It is an antagonist of the in vitro response to oxytocin (pA2 value = 6.93 +/- 0.10). dPTyr(Me)AVP has an antivasopressor pA2 of 7.96 +/- 0.05 and an antidiuretic potency of 3.5 +/- 0.5 units/mg. It is also an antagonist of the in vitro oxytocic response to oxytocin (pA2 value = 7.61 +/- 0.14). It is thus one of the most potent vasopressor antagonists reported to date.
Viscometric temperature measurement in electric or magnetic fields (1984)

In the presence of electrostatic or electromagnetic fields, the viscometric thermometer is one of the few possible and feasible methods of temperature measurement. The device can be operated in a constant pressure or a constant flow mode. The former system is simpler and easier to build and operate but it requires a relatively long reading time of 1 to 2 min and, consequently, can be used only in ‘‘steady-state’’ flows where the variations in temperature are much slower than the reading time required. Different configurations and measurement procedures are described. In particular, a viscometric thermometer was designed and built for the constant pressure mode which enabled us to obtain the temperature distribution inside the channel of an electrohydrodynamic pump.
Synthetic Muscle Electroactive Polymer (EAP) based actuation and pressure sensing for prosthetic and robotic gripper applications (2019)

Ras Labs’ Synthetic Muscle technology promises to resolve major issues facing amputees, most notably the pain of prosthetic slippage and tissue breakdown. Synthetic Muscle, comprising electroactive polymers (EAPs), actively expand or contract at low voltages, while offering impact resistance and pressure sensing, in one integrated solution. In collaboration with United Prosthetics (UPI), customer testing was initiated with these EAP based pads located in strategic areas of the prosthetic socket of both below knee (BK) and above knee (AK) amputees for evaluation and feedback, with very promising results. The goal is to give amputees natural locomotion with a worry-free prosthesis, maintaining dynamic perfect fit throughout the day and preventing tissue damage from even beginning to occur. Robotic gripper applications, with sensing fingertips, were also prototyped. Characterization of Synthetic Muscle as dual use pressure sensors was investigated, with variable voltage observed and quantified when the EAP sensor was mechanically compressed. The integration of EAP shape-morphing actuation into grippers was also initiated. The EAP shape-morphing control is expected to be modulated as needed by controlling the voltage level. This technology is expected to provide for an adjustable prosthetic liner or socket that can maintain dynamic perfect fit and for biomimetic prosthetic hands and robotic grippers.
Genetic Adaptive Neural Network to Predict Biochemical Failure After Radical Prostatectomy: A Multi-institutional Study (2001)

It was possible to predict PSA recurrence with a high accuracy (76%). Physicians desiring objective treatment counseling can use this model, and significant cost savings are anticipated because of appropriate treatment selection and patient-specific follow-up protocols. This technology can be extended to other treatments such as watchful waiting, external-beam radiation, and brachytherapy.
A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports (2011)

Our method provides an option for detecting hidden interactions in spontaneous reporting systems by using side effect profiles to infer the presence of unreported adverse events.
IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility (2019)

IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness. In this study, by cell type-specific deletion of IL-17R and adaptor Act1, we demonstrated that IL-17R/Act1 exerts a direct impact on the contraction of airway smooth muscle cells (ASMCs). Mechanistically, IL-17A induced the recruitment of Rab35 (a small monomeric GTPase) and DennD1C (guanine nucleotide exchange factor [GEF]) to the IL-17R/Act1 complex in ASMCs, resulting in activation of Rab35. Rab35 knockdown showed that IL-17A-induced Rab35 activation was essential for protein kinase Cα (PKCα) activation and phosphorylation of fascin at Ser39 in ASMCs, allowing F-actin to interact with myosin to form stress fibers and enhance the contraction induced by methacholine. PKCα inhibitor or Rab35 knockdown indeed substantially reduced IL-17A-induced stress fiber formation in ASMCs and attenuated IL-17A-enhanced, methacholine-induced contraction of airway smooth muscle. Taken together, these data indicate that IL-17A promotes airway smooth muscle contraction via direct recruitment of Rab35 to IL-17R, followed by PKCα activation and stress fiber formation.
RTVP-1, a Tumor Suppressor Inactivated by Methylation in Prostate Cancer (2004)

We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.
Continuous Pig Iron Making by Microwave Heating with 12.5 kW at 2.45 GHz (2011)

A continuous process of pig iron making using microwave of 2.45 GHz was constructed in a microwave furnace with maximum power of 12.5 kW. Pig iron was produced from the mixed powder of magnetite ore and carbon such as coal, coke and graphite. Molten pig iron initially poured from reaction chamber after about 40 min when temperature attained over 1200 degrees C. After temperature attained at 1400 degrees C, 50 or 200 g of mixed powder was added several times in regular interval and pig iron continuously dropped out from reaction chamber. When mixed powder was supplied, temperature in reaction chamber decreased by about 200 degrees C and recovered during 5 min. Finally, the recovery time of temperature lengthened. In order to make the scale-up of the microwave furnace for iron making, it has been discussed how to improve energy efficiency and to make a preferable construction.
Schottky barrier heights of Pt and Ir silicides formed on Si/SiGe measured by internal photoemission (1994)

Lowered-barrier-height silicide Schottky diodes are desirable for obtaining longer cutoff-wave- length Si-based infrared detectors. Silicide Schottky diodes have been fabricated by the reaction of evaporated Pt and Ir films on p-Si1−xGex alloys with a thin Si capping layer. The onset of metal-SiGe reactions was controlled by the deposited metal thickness. Internal photoemission measurements were made and the barrier heights were obtained from these. Pt-SiGe and Ir-SiGe reacted diodes have barrier heights of ∼0.27 and ∼0.31 eV, respectively, higher than typical values of 0.22 and 0.12 eV for the corresponding silicide/p-Si diodes. Their emission constants are also lower and more voltage dependent than silicide/Si diodes. PtSi/Si/SiGe diodes, on the other hand, have lower barrier heights (∼0.15 eV) than the PtSi/Si barrier height. The barrier height shifts in such silicide/Si/SiGe diodes are interpreted by accounting for tunneling through the unconsumed Si layer. This is done analytically using a simple model based on the Cohen, Vilms, and Archer (unpublished) modification to the Fowler equation, and leads to an extracted barrier height, that is, the Si barrier height reduced by the Si/SiGe band offset.
Modification of BTLA signaling motifs in TIL exhibits positive signals that mediate anti-tumor control (2015)

Meeting abstracts Our recent data have shown that a subset of CD8+BTLA+ was the strongest predictive biomarker of response to adoptive T cell therapy using tumor-infiltrating lymphocytes. BTLA, B-and-T lymphocyte attenuator, is known as an inhibitory molecule in different immune cells. Its
VPW (2010)

The Visual Paired Comparison (VPC) task is widely used to measure recognition memory in psychology and neuroscience research. Recently, the VPC task has shown promise as a diagnostic for the amnestic subtype of Mild Cognitive Impairment (aMCI). Patients diagnosed with aMCI are at an increased risk for developing dementia, especially Alzheimer's disease. However, current implementations of VPC require eye tracking equipment, which is costly and not widely available. This demonstration shows our early prototype of a Web-based version of the VPC task, the Viewport Viewing task (VPW), that requires only a computer with a mouse. A key contribution of VPW is using a computer mouse to induce viewing behavior similar to the original VPC task, so that it can be analyzed to measure the subject's novelty preference. Additionally, the interactive VPW prototype provides data visualization and exploration capabilities to help a clinician or researcher analyze the resulting data. VPW has the potential to extend the accessibility of cognitive diagnostics, allowing for Web-based behavioral screening for aMCI to be deployed world-wide, without requiring any special-purpose equipment. Such a tool would have wide-ranging implications for early diagnosis, for cognitive research, and for clinical practice.
Development of a miRNA-based diagnostic assay for pancreatic ductal adenocarcinoma (2011)

Diagnosis of pancreatic cancer remains a clinical challenge. Both chronic pancreatitis and pancreatic cancer may present with similar symptoms and similar imaging features, often leading to incorrect interpretation. Thus, the use of an objective molecular test that can discriminate between chronic pancreatitis and pancreatic cancer will be a valuable asset in obtaining a definitive diagnosis of pancreatic cancer. Following Clinical Laboratory Improvement Amendments and College of American Pathologists guidelines, Asuragen Clinical Services Laboratory has developed and validated a laboratory-developed test, miRInform(®) Pancreas, to aid in the identification of pancreatic ductal adenocarcinoma. This molecular diagnostic tool uses reverse-transcription quantitative PCR to measure the expression difference between two miRNAs, miR-196a and miR-217, in fixed tissue specimens. This article describes the test validation process as well as determination of performance parameters of miRInform Pancreas.
Abstract 2939: Chk1 inhibition and Wee1 inhibition combine synergistically to inhibit cellular proliferation (2011)

Abstract Inhibition of the checkpoint kinase Chk1, both as a monotherapy and in combination with DNA damaging cytotoxics, is a promising therapeutic strategy for human cancer. However, much remains to be learned in regard to the patient populations that will respond best to a Chk1 inhibitor and the optimal therapeutics to combine with a Chk1 inhibitor. In an effort to discover sensitizing mutations and novel combination strategies for Chk1 inhibition, we performed a synthetic lethality siRNA screen with the selective Chk1 inhibitor Chk1-A. This screen employed a custom made library of siRNAs against 197 genes (3 siRNAs per gene), most of which are involved in cell-cycle control or DNA damage repair. One of the most prominent and consistent hits across runs of the screen performed in PC3, LNCaP, and A549 cell lines was Wee1 kinase. MK-1775 is a small molecule inhibitor of Wee1 that is currently in early stage clinical trials. In confirmation of the results obtained from the siRNA screen, we found that Chk1-A and MK-1775 synergistically inhibited proliferation in multiple cell types. The combination of the two molecules resulted in up to a 5-fold enhancement of anti-proliferative activity compared to what would be expected from pure additivity. This anti-proliferative synergy correlated with a synergistic induction of apoptosis. We explored the mechanism of the impressive synergy by examining the cellular and biochemical effects of the Chk1-A and MK-1775 combination. We found that co-treatment with the two inhibitors resulted in dramatic decreases in inhibitory phosphorylation of cyclin-dependent kinases 1 and 2, increases in DNA damage, and the collapse of DNA replication. In conclusion, the combination of a Chk1 inhibitor and a Wee1 inhibitor may be an effective treatment strategy for cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2939. doi:10.1158/1538-7445.AM2011-2939