gebhart/patrepeval huggingface dataset:
Image processing and machine learning for diagnostic analysis of microcirculation (2009)

This study focuses on detection of capillaries and small blood vessels in the videos recorded from the lingual surface using Microscan SDF system. The purpose of this study is to quantitatively monitor and assess the changes that occur in microcirculation during resuscitation period. The results assist physicians in making diagnostically and therapeutically important decisions such as determination of the effectiveness of the resuscitation process. The proposed algorithm applies advanced digital image processing methods to provide quantitative assessment of video signals for detection and characterization of capillaries. The objective of the algorithm is to segment capillaries, estimate the presence and velocity of Red Blood Cells (RBCs), and identify the distribution of blood flow in capillaries for a variety of normal and abnormal cases. The algorithm first, stabilizes each frame to follow the variations in the consecutive frames. Then, time-averaging techniques are applied to the frames to reduce the motion artifact. Histogram equalization, wavelet transform, and median filtering are the subsequent steps applied to accurately detect the blood vessels in each frame. In order to estimate the velocity of RBCs, space time diagrams are obtained through cross-correlation calculations. This study aims to reduce the human interaction as well as the computation time.
Dopamine Neuron Stimulating Actions of a GDNF Propeptide (2010)

Collectively, these data support that DNSP-11 exhibits potent neurotrophic actions analogous to GDNF, making it a viable candidate for a PD therapeutic. However, it likely signals through pathways that do not directly involve the GFRalpha1 receptor.
3-D Integrated Inductors and Transformers on Liquid Crystal Polymer Substrate (2006)

We have designed, fabricated, and tested inductors and transformers on LCP substrate which exhibit high Q and high self-resonant frequency using a 3-D fabrication technology. A 1.1nH inductor in this work achieves a quality factor Q of 76 at 12GHz, with Q over 60 for frequencies from 8 to 18GHz. A 1:1 ratio transformer with coupling factors, k of higher than 0.6 and a self resonance frequency of 23GHz is also fabricated and tested. The technology for these inductors and transformers is based on one step Cr/Au metal deposition and electroplating
Overview of the Preclinical Development of an Antiretroviral Drug, 2′,3′-Dideoxyinosine (1990)

AIDS has remained a significant and worsening medical problem since its first description as a new clinical entity in 1981. In the past 6 years, substantial progress has been made in the chemotherapy for this disease; such progress is likely to exert a major effect on the epidemic of human immunodeficiency virus infection in the coming decade. In this article, we overview the preclinical development of an antiretroviral drug, 2',3'-dideoxyinosine (didanosine; ddI), which has recently been shown in early phase I studies to have activity against human immunodeficiency virus in patients with AIDS or AIDS-related complex. Although we will not know the full clinical potential of ddI until we have the results of ongoing controlled clinical trials, this drug appears to possess desirable features for clinical use.
Solid-state cathode materials for lithium batteries: effect of synthesis temperature on the physical and electrochemical properties of silver vanadium oxide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleSolid-state cathode materials for lithium batteries: effect of synthesis temperature on the physical and electrochemical properties of silver vanadium oxideRandolph A. Leising and Esther Sans TakeuchiCite this: Chem. Mater. 1993, 5, 5, 738–742Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/cm00029a029https://doi.org/10.1021/cm00029a029research-articleACS PublicationsRequest reuse permissionsArticle Views463Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Image sharpness increase in systems with double line addressing (2001)

The double line addressing method can be applied to matrix displays with the purpose of effectively decreasing the time necessary for line addressing. In this system, two neighboring lines are addressed simultaneously and receive the same data, which leads to considerable decrease of image sharpness. In order to overcome this problem, the image can be pre-processed by the algorithm described in this application. This algorithm is based on the ability of the human eye to merge quick signals. Namely, when the double line addressing system is applied, the viewer cannot see the odd and even frame separately due to the quick frame change, but their average. The goal of the presented idea is to change the incoming information in such a way that the average image corresponds to the original image as much as possible.
Abstract B50: A new class of diazonamide analogs with improved antitumor activity (2010)

Abstract Diazonamide A is a natural product originally isolated from a marine organism. It potently induces G2/M cell cycle arrest. Its molecular mode of action is not fully understood but its potential as a cancer therapeutic is high. We previously reported that AB5, a close analog of diazonamide A, exhibits potent anti-tumor activity in mouse xenograft models. Tumor regression occurs in the absence of systemic toxicity typical of anti-mitotic chemotherapy. Here we show for the first time that the natural diazonamide compound possesses strong tumor killing activity in vivo xenograft models. To streamline our diazonamide synthesis and to define a minimal pharmacophore, we prepared a series of truncated structures. One of these, JP1838, was found to be as potent as AB5. Its simplified structure and shortened synthesis allowed for extensive structure activity relationship analyses. Several modifications markedly improved activity. One analog, JP2295, is &gt;20 fold more potent than AB5 in a MIA Paca-2 pancreatic cancer xenograft model. More importantly, in HPAC pancreatic cancer and HCT-116 colon cancer xenograft models, JP2295 demonstrates greater efficacy and less toxicity than docetaxel and vinorelbine. Safety studies were therefore carried out in NIH Swiss mice. At doses10-fold higher than required for strong efficacy, JP2295 does not exhibit toxicities common to docetaxel and vinorelbine treatments. These include body weight loss, neutropenia, and myelosuppression. Such a large therapeutic window is unique for a small molecule antimitotic and suggests further development is warranted. Citation Information: Clin Cancer Res 2010;16(14 Suppl):B50.
Improving the fatty acid composition of soybean oil (1984)

Abstract Efforts to improve the composition of soybean oil by breeding the beans for low linolenic acid in the oil have continued since 1968. This paper reports recent work using hybrid crosses and induced mutations. No lines are yet available that contain oil having less than 3% linolenic acid.
Gauss von Mises Distribution for Improved Uncertainty Realism in Space Situational Awareness (2014)

In order to provide a more statistically rigorous treatment of uncertainty in the space surveillance tracking environment, a new class of multivariate probability density functions is proposed called the Gauss von Mises (GVM) family of distributions. The distinguishing feature of the GVM distribution is its definition on a cylindrical manifold, the underlying state space in which systems of orbital element coordinates are more accurately defined. When specialized to GVM distributions, the prediction step of the general Bayesian nonlinear filter is shown to be tractable and viable, thereby providing a novel means to propagate space object orbital uncertainty under nonlinear perturbed two-body dynamics. Results demonstrate that uncertainty propagation with the new GVM distribution can be achieved at the same cost as the traditional unscented Kalman filter and can maintain “uncertainty realism” for up to eight times as long.
Burst-mode compatible optical receiver with a large dynamic range (1990)

A description is given of the characteristics and performance of a burst-mode receiver for optical data communication that employs a differential transimpedance amplifier and an auto-threshold-tracking level control circuit in the preamplifier. The differential outputs of the preamplifier are DC-coupled to the decision circuit to achieve burst-mode compatibility. The receiver was assembled in a compact dual inline package with an optical connector. The typical sensitivities are around -31.5 and -29.5 dBm/Av at 200 Mb/s (at a bit error rate of 10/sup -9/) for pseudorandom and burst-mode signals, respectively, with dynamic ranges of 27.5 and 25.5 dB, respectively. The operating bit rate ranges from DC to 500 Mb/s, and the differential outputs are true ECL (emitter-coupled logic).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Mutation in the β3 Subunit of the Cardiac Sodium Channel Associated With Brugada ECG Phenotype (2009)

Our results provide support for the hypothesis that mutations in SCN3B can lead to loss of transport and functional expression of the hNa(v)1.5 protein, leading to reduction in sodium channel current and clinical manifestation of a Brugada phenotype.
High-Pressure CO<sub>2</sub>/CH<sub>4</sub> Separation Using SAPO-34 Membranes (2005)

SAPO-34 membranes on stainless steel, tubular supports separated CO2 from CH4 at feed pressures up to 3.1 MPa. The highest CO2 permeance was 2.4 × 10-7 mol/(m2 s Pa) for a 50/50 feed mixture at a pressure drop of 0.14 MPa. For a pressure drop of 3 MPa, the CO2/CH4 separation selectivities at 253 K were 140−150; at lower pressure drops, the highest selectivity was 270. The highest CO2 flux was 21 kg/(m2 h) at 295 K and a pressure drop of 3 MPa. Separation selectivity decreased as temperature increased because separation was partly based on competitive adsorption. As transmembrane pressure drop increased, both CO2 flux and CO2 permeate concentration increased for a 50/50 mixture. The flux pressure dependence was modeled by Maxwell−Stefan diffusion for mixtures. Methane decreased the CO2 diffusion rate and, thus, decreased the CO2 flux. The CH4 flux was also lower in a mixture because CO2 inhibits CH4 adsorption.
Envelope-memory nonlinear model for power amplifiers (1998)

The existing models for TWTA are not enough accurate to predict the intermodulation produced in a SSPA. In this paper a new model for the SSPAs is presented to simulate the nonlinear behavior of solid state power amplifiers. Inherently, it produces the third order intermodulation products accurately. This model is based on static together with dynamic measurements. A good agreement has been found between measured and calculated curves such as Noise Power Ratio (NPR) and Bit Error Rate (BER) curves.
Combining Behavior Models to Secure Email Systems (2003)

We introduce the Email Mining Toolkit (EMT), a system that implements behavior-based methods to improve security of email systems. Behavior models of email flows and email account usage may be used for a variety of detection tasks. Behavior-based models are quite different from "content-based" models in common use today, such as virus scanners. We evaluate the soundness of these techniques for the detection of the onset of viral propagations. The results achieved for the detection of the onset of viral propagations suggest email delivery should be egress rate limited - stored for a while and then forwarded - or a record of recently delivered emails should be kept in order to develop sufficient statistics to verify a propagation is ongoing. EMT can form part of a larger security platform that deals with email security issues in general. We present the variety of EMT models implemented to date and suggest other security tasks that may benefit for its detection capabilities.
Design and implementation of a dc-based magnetic field controller (1990)

This invention is comprised of a magnetic field controller for laboratory devices and in particular to dc operated magnetic field controllers for mass spectrometers, comprising a dc power supply in combination with improvements to a hall probe subsystem, display subsystem, preamplifier, field control subsystem, and an output stage. 1 fig.
Coherence Reflectance Confocal Microscope using a Synthesized Broadband Source (2006)

A coherence reflectance confocal microscope was built using a broad-band light source synthesized from multiple high-power semiconductor lasers. The resolution of the microscope was measured as well as the image power spectrum of skin tissue.
Hydrogenation of coal liquid utilizing a metal carbonyl catalyst. [US DOE patent] (1979)

1. Albumin causes calcium signals and mitosis in cultured astrocytes, but it has not been established whether astrocytes in intact brain also respond to albumin. The effect of albumin on intracellular calcium concentration ([Ca2+]i) in single cells was therefore studied in acutely isolated cortical brain slices from the neonatal rat. 2. Physiological concentrations of albumin from plasma and from serum produced an increase in [Ca2+]i in a subpopulation of cortical cells. Trains of transient elevations in [Ca2+]i (Ca2+ spikes) were seen in 41 % of these cells. 3. The cells responding to albumin are identified as astrocytes because the neurone-specific agonist NMDA caused much smaller and slower responses in these cells. On the other hand NMDA-responsive cells, which are probably neurones, exhibited only small and slow responses to albumin. The residual responses of astrocytes to NMDA and neurones to albumin are likely to be due to crosstalk with adjacent neurones and astrocytes, respectively. 4. Methanol extraction of albumin removes a polar lipid and abolishes the ability of albumin to increase intracellular calcium. 5. Astrocyte calcium signalling caused by albumin may have important physiological consequences when the blood-brain barrier breaks down and allows albumin to enter the CNS.
Molecular Basis for the Toxicity of Schweinfurthins to Breast Cancer Cells (2003)

Abstract : The schweinfurthins are a small set of diprenylated stilbenes isolated from an African plant. Schweinfurthins A, and B display significant and unique activity in the NCI's 60 cell line panel, and the breast cancer lines MCF7 and HS 578T were among the most sensitive. We have developed multiple convergent routes to this family of compounds allowing an analog retaining anticancer activity to be synthesized as a single enantiomer. We have now synthesized a series of analogs including one bearing suitable functional groups for attachment to an affinity reagent or other reagent for determination of the mechanism of action. These studies have also led to synthetic analogs with more favorable stability, improving the ability to handle these agents. Quantitative structure activity studies have advanced our understanding of the essential pharmacophore and will pave the way for design of next generation analogs targeted at increasing the potency of the schweinfurthin family.
A Low Complexity Integer Frequency Offset Estimation Scheme Based on Coherence Phase Bandwidth for OFDM Systems (2013)

In this paper, we propose a low complexity integer frequency offset estimation scheme based on coherence phase bandwidth for orthogonal frequency division multiplexing (OFDM) systems. The proposed scheme overcomes the effect of the timing offset via correlating the local and received OFDM training symbols in a coherence phase bandwidth block unit. Moreover, by utilizing a threshold to determine an interger frequency offset etimate, the proposed scheme need not calculate correlation values for all possible interger frequency offset candidates. From numerical results, it is demonstrated that the proposed scheme can estimate the integer freqeuncy offset with a reduced complexity while minataining the same level of the estimation performance.
Dual-Polarized Filtering Antenna With High Selectivity and Low Cross Polarization (2016)

This paper presents a dual-polarized patch antenna with quasi-elliptic bandpass responses. The proposed antenna is mainly composed of a feeding network, a driven patch, and a stacked patch, with its entire height being 0.09λ. The feeding network consists of two orthogonal H-shaped lines that coupled to the driven patch, each for one polarization. The elaborately designed feeding lines not only ensure a sharp roll-off rate at the lower band edge, but also help to achieve low cross polarization and high isolation between two feeding ports. On the other hand, the upper stacked patch provides improved suppression levels at the upper stopband and also an enhanced gain within passband. Consequently, a compact dual-polarized antenna with satisfying filtering performance is obtained, without using extra filtering circuits. For demonstration, an antenna is designed to fit the specification of LTE band (2.49-2.69 GHz). The implemented antenna achieves an average a gain of 9 dBi, a cross-polarization ratio of 29 dB, an isolation of 35 dB within LTE band. The out-of-band suppression level is more than 40 dB within the 2G and 3G frequency bands from 1.71-2.17 GHz. It can be used as the antenna elements in multiband base station antenna arrays to reduce the mutual coupling.
Development and Preliminary Evaluation of a Multivariate Index Assay for Ovarian Cancer (2009)

We describe a blood-based assay using 11 analytes that can distinguish women with ovarian cancer from those with benign conditions. Preliminary evaluation of the classifier suggests it has the potential to offer approximately 90% sensitivity and 90% specificity. While promising, the performance needs to be assessed in a blinded clinical validation study.
A localized contour tree method for deriving geometric and topological properties of complex surface depressions based on high-resolution topographical data (2015)

Surface depressions are abundant in topographically complex landscapes, and they exert significant influences on hydrological, ecological, and biogeochemical processes at local and regional scales. The increasing availability of high-resolution topographical data makes it possible to resolve small surface depressions. By analogy with the reasoning process of a human interpreter to visually recognize surface depressions from a topographic map, we developed a localized contour tree method that is able to fully exploit high-resolution topographical data for detecting, delineating, and characterizing surface depressions across scales with a multitude of geometric and topological properties. In this research, we introduce a new concept ‘pour contour’ and a graph theory-based contour tree representation for the first time to tackle the surface depression detection and delineation problem. Beyond the depression detection and filling addressed in the previous raster-based methods, our localized contour tree method derives the location, perimeter, surface area, depth, spill elevation, storage volume, shape index, and other geometric properties for all individual surface depressions, as well as the nested topological structures for complex surface depressions. The combination of various geometric properties and nested topological descriptions provides comprehensive and essential information about surface depressions across scales for various environmental applications, such as fine-scale ecohydrological modeling, limnological analyses, and wetland studies. Our application example demonstrated that our localized contour tree method is functionally effective and computationally efficient.
A Communication interface using vesicles embedded with channel forming proteins in molecular communication (2007)

This paper describes design and empirically study of a communication interface in molecular communication. The communication interface hides the characteristics of the molecules during the propagation from the sender to a receiver to allow a generic transport of molecules independent of the characteristics. The authors of this paper propose a communication interface that uses a vesicle embedded with channel forming proteins. The channel forming proteins embedded with the vesicle form communication channels between the vesicle itself and a sender/receiver. The proposed molecular communication interface uses vesicle to hide the characteristics of the molecules and the communication channels to encapsulate/decapsulate the molecules into/from the vesicle. The vesicle receives the molecules from the sender through the communication channels formed between the vesicle itself and the sender. The molecules are encapsulated in the vesicle, and their characteristics are hidden by the vesicle structure during the propagation to a receiver. At the receiver, the molecules are transferred into the receiver through the communication channels formed between the vesicle itself and the receiver. The authors of this paper constructed the vesicles embedded with channel forming proteins and the molecules were successfully encapsulated into the vesicle. It was also demonstrated that molecules were transferred through the communication channels.
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations (2020)

Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. An extract of the mushroom Lepista inversa has recently shown high-efficiency correction of UGA and UAA nonsense mutations. One active constituent of this extract is 2,6-diaminopurine (DAP). In Calu-6 cancer cells, in which TP53 gene has a UGA nonsense mutation, DAP treatment increases p53 level. It also decreases the growth of tumors arising from Calu-6 cells injected into immunodeficient nude mice. DAP acts by interfering with the activity of a tRNA-specific 2'-O-methyltransferase (FTSJ1) responsible for cytosine 34 modification in tRNA<sup>Trp</sup>. Low-toxicity and high-efficiency UGA nonsense mutation correction make DAP a good candidate for the development of treatments for genetic diseases caused by nonsense mutations.
Regioselective Synthesis of 1,4-Di(organo)[60]fullerenes through DMF-assisted Monoaddition of Silylmethyl Grignard Reagents and Subsequent Alkylation Reaction (2008)

Monoaddition of Grignard reagents, in particular tri(organo)silylmethylmagnesium chlorides, to [60]fullerene took place smoothly in the presence of dimethylformamide to produce (organo)(hydro)[60]fullerenes, C60R(1)H, in good yield (up to 93% isolated yield). The hydrofullerene was then deprotonated to generate the corresponding anion, C60R(-), which was then alkylated to obtain 58pi-electron di(organo)[60]fullerenes, C60R(1)R(2), in good to high yield (up to 93% overall yield). The two-step methodology provides a wide variety of 1,4-di(organo)[60] fullerenes bearing the same or different organic addends on the [60] fullerene core. By changing the addends, one can control the chemical and physical properties of the compounds at the molecular and bulk levels.