gebhart/patrepeval huggingface dataset:
Synthesis and Growth Mechanism of Bi<sub>2</sub>S<sub>3</sub> Nanoribbons (2004)

This article describes a facile solvothermal method by using mixed solvents for the large-scale synthesis of Bi(2)S(3) nanoribbons with lengths of up to several millimeters. These nanoribbons were formed by a solvothermal reaction between Bi(III)-glycerol complexes and various sulfur sources in a mixed solution of aqueous NaOH and glycerol. HRTEM (high-resolution transmission electron microscopy) and SAED (selective-area electron diffraction) studies show that the as-synthesized nanoribbons had predominately grown along the [001] direction. The Bi(2)S(3) nanoribbons prepared by the use of different sulfur sources have a common formation process: the initial formation of NaBiS(2) polycrystals, which serve as the precursors to Bi(2)S(3), the decomposition of NaBiS(2), and the formation of Bi(2)S(3) seeds in the solution through a homogeneous nucleation process; the growth of Bi(2)S(3) nanoribbons occurs at the expense of NaBiS(2) materials. The growth mechanism of millimeter-scale nanoribbons involves a special solid-solution-solid transformation as well as an Ostwald ripening process. Some crucial factors affect nanoribbon growth, such as, solvothermal temperature, volume ratio of glycerol to water, and the concentration of NaOH; these have also been discussed.
Efficient Coflow Scheduling Without Prior Knowledge (2015)

Inter-coflow scheduling improves application-level communication performance in data-parallel clusters. However, existing efficient schedulers require a priori coflow information and ignore cluster dynamics like pipelining, task failures, and speculative executions, which limit their applicability. Schedulers without prior knowledge compromise on performance to avoid head-of-line blocking. In this paper, we present Aalo that strikes a balance and efficiently schedules coflows without prior knowledge.
Microglial Calcium Release-Activated Calcium Channel Inhibition Improves Outcome from Experimental Traumatic Brain Injury and Microglia-Induced Neuronal Death (2018)

Store-operated Ca<sup>2+</sup> entry (SOCE) mediated by calcium release-activated calcium (CRAC) channels contributes to calcium signaling. The resulting intracellular calcium increases activate calcineurin, which in turn activates immune transcription factor nuclear factor of activated T cells (NFAT). Microglia contain CRAC channels, but little is known whether these channels play a role in acute brain insults. We studied a novel CRAC channel inhibitor to explore the therapeutic potential of this compound in microglia-mediated injury. Cultured microglial BV2 cells were activated by Toll-like receptor agonists or IFNγ. Some cultures were treated with a novel CRAC channel inhibitor (CM-EX-137). Western blots revealed the presence of CRAC channel proteins STIM1 and Orai1 in BV2 cells. CM-EX-137 decreased nitric oxide (NO) release and inducible nitric oxide synthase (iNOS) expression in activated microglia and reduced agonist-induced intracellular calcium accumulation in microglia, while suppressing inflammatory transcription factors nuclear factor kappa B (NF-κB) and nuclear factor of activated T cells (NFAT). Male C57/BL6 mice exposed to experimental brain trauma and treated with CM-EX-137 had decreased lesion size, brain hemorrhage, and improved neurological deficits with decreased microglial activation, iNOS and Orai1 and STIM1 levels. We suggest a novel anti-inflammatory approach for managing acute brain injury. Our observations also shed light on new calcium signaling pathways not described previously in brain injury models.
Microporous Polymeric Materials by Microemulsion Polymerization: Effect of Surfactant Concentration (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicroporous Polymeric Materials by Microemulsion Polymerization: Effect of Surfactant ConcentrationT. H. Chieng, L. M. Gan, C. H. Chew, L. Lee, S. C. Ng, K. L. Pey, and D. GrantCite this: Langmuir 1995, 11, 9, 3321–3326Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/la00009a010https://doi.org/10.1021/la00009a010research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease (2013)

Alzheimer disease (AD) is the most prevalent cause of dementia. Amyloid-β (Aβ) oligomers are potent synaptotoxins thought to mediate AD-related phenotypes. Cellular prion protein (PrP(C)) has been identified as a high-affinity receptor for Aβ oligomers. Herein, we review the functional consequences of Aβ oligomer binding to PrP(C) on the neuronal surface. We highlight recent evidence that Fyn kinase mediates signal transduction downstream of the PrP(C)-Aβ oligomer complex. These studies suggest that PrP(C) has a central role in AD pathogenesis and may provide a target for therapeutic intervention in AD.
Governance on the Drug Supply Chain via Gcoin Blockchain (2018)

As a trust machine, blockchain was recently introduced to the public to provide an immutable, consensus based and transparent system in the Fintech field. However, there are ongoing efforts to apply blockchain to other fields where trust and value are essential. In this paper, we suggest Gcoin blockchain as the base of the data flow of drugs to create transparent drug transaction data. Additionally, the regulation model of the drug supply chain could be altered from the inspection and examination only model to the surveillance net model, and every unit that is involved in the drug supply chain would be able to participate simultaneously to prevent counterfeit drugs and to protect public health, including patients.
High velocity SAW using aluminum nitride film on unpolished nucleation side of freestanding CVD diamond (2003)

High performances surface acoustic wave filters based on AlN/diamond layered structure were performed. C-axis oriented aluminum nitride films with various thicknesses were sputtered on unpolished nucleation side (NS) of freestanding polycrystalline CVD diamond obtained by silicon substrate etching. Experimental results show that high order modes as well as Rayleigh waves are excited. Experimental results are in a good agreement with the calculated dispersion curves which were determined by software simulation with Green's function formalism. We demonstrate clearly that SAW devices combining high phase velocity, high electromechanical coupling coefficient and low temperature coefficient can be performed with AlN/diamond structure.
Anaerobic oxidation of ammonium is a biologically mediated process (1995)

A newly discovered process by which ammonium is converted to dinitrogen gas under anaerobic conditions (the Anammox process) has now been examined in detail. In order to confirm the biological nature of this process, anaerobic batch culture experiments were used. All of the ammonium provided in the medium was oxidized within 9 days. In control experiments with autoclaved or raw wastewater, without added sludge or with added sterilized (either autoclaved or gamma irradiated) sludge, no changes in the ammonium and nitrate concentrations were observed. Chemical reactions could therefore not be responsible for the ammonium conversion. The addition of chloramphenicol, ampicillin, 2,4-dinitrophenol, carbonyl cyanide m-chlorophenyl-hydrazone (CCCP), and mercuric chloride (HgIICl2) completely inhibited the activity of the ammonium-oxidizing sludge. Furthermore, the rate of ammonium oxidation was proportional to the initial amount of sludge used. It was therefore concluded that anaerobic ammonium oxidation was a microbiological process. As the experiments were carried out in an oxygen-free atmosphere, the conversion of ammonium to dinitrogen gas did not even require a trace of O2. That the end product of the reaction was nitrogen gas has been confirmed by using 15NH4+ and 14NO3-. The dominant product was 14-15N2. Only 1.7% of the total labelled nitrogen gas produced was 15-15N2. It is therefore proposed that the N2 produced by the Anammox process is formed from equimolar amounts of NH4+ and NO3-.
Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden (2021)

There is a critical need for improved pharmacodynamic markers for use in human tuberculosis (TB) drug trials. Pharmacodynamic monitoring in TB has conventionally used culture or molecular methods to enumerate the burden of Mycobacterium tuberculosis organisms in sputum. A recently proposed assay called the rRNA synthesis (RS) ratio measures a fundamentally novel property, how drugs impact ongoing bacterial rRNA synthesis. Here, we evaluated RS ratio as a potential pharmacodynamic monitoring tool by testing pretreatment sputa from 38 Ugandan adults with drug-susceptible pulmonary TB. We quantified the RS ratio in paired pretreatment sputa and evaluated the relationship between the RS ratio and microbiologic and molecular markers of M. tuberculosis burden. We found that the RS ratio was highly repeatable and reproducible in sputum samples. The RS ratio was independent of M. tuberculosis burden, confirming that it measures a distinct new property. In contrast, markers of M. tuberculosis burden were strongly associated with each other. These results indicate that the RS ratio is repeatable and reproducible and provides a distinct type of information from markers of M. tuberculosis burden. <b>IMPORTANCE</b> This study takes a major next step toward practical application of a novel pharmacodynamic marker that we believe will have transformative implications for tuberculosis. This article follows our recent report in <i>Nature Communications</i> that an assay called the rRNA synthesis (RS) ratio indicates the treatment-shortening of drugs and regimens. Distinct from traditional measures of bacterial burden, the RS ratio measures a fundamentally novel property, how drugs impact ongoing bacterial rRNA synthesis.
RESEARCH ARTICLE: Systematic Assessment of BDNF and Its Receptor Levels in Human Cortices Affected by Huntington's Disease (2008)

One cardinal feature of Huntington's disease (HD) is the degeneration of striatal neurons, whose survival greatly depends on the binding of cortical brain-derived neurotrophic factor (BDNF) with high-affinity (TrkB) and low-affinity neurotrophin receptors [p75 pan-neurotrophin receptor (p75(NTR))]. With a few exceptions, results obtained in HD mouse models demonstrate a reduction in cortical BDNF mRNA and protein, although autopsy data from a limited number of human HD cortices are conflicting. These studies indicate the presence of defects in cortical BDNF gene transcription and transport to striatum. We provide new evidence indicating a significant reduction in BDNF mRNA and protein in the cortex of 20 HD subjects in comparison with 17 controls, which supports the hypothesis of impaired BDNF production in human HD cortex. Analyses of the BDNF isoforms show that transcription from BDNF promoter II and IV is down-regulated in human HD cortex from an early symptomatic stage. We also found that TrkB mRNA levels are reduced in caudate tissue but not in the cortex, whereas the mRNA levels of T-Shc (a truncated TrkB isoform) and p75(NTR) are increased in the caudate. This indicates that, in addition to the reduction in BDNF mRNA, there is also unbalanced neurotrophic receptor signaling in HD.
High Birefringence Nematic Liquid Crystals for Display and Telecom Applications (2004)

Several compounds with high birefringence and having tolane structure were synthesized. For a high polarizability, isothiocyanato (NCS) terminal group was introduced. Another goal of this study was reduction of melting point and smectic phases by introduction of fluorine as lateral substituent. The transition temperatures for all the synthesized compounds and the refractive and dielectric indices for one of the compounds have been determined. Electro-optic (EO) measurements were also performed.
Quantification of Mold in Hay by near Infrared Reflectance Spectroscopy (1987)

Near infrared reflectance spectroscopy was used to quantify mold by spectrally predicting chitin, a fungal cell wall polymer of glucosamine. Chitin data and near infrared reflectance spectra were collected from moldy alfalfa (Medicago sativa L.) hay samples. Chitin concentrations ranged from 75 to 710/ag/g DM and were similar to concentrations in other contaminated products. Second derivative math transformations were made on the spectra, and a calibration equation was developed by regressing transformed spectra against chemical data. The coefficients of determination for calibration and validation were .90 and .82, respectively. Standard errors of calibration and validation were 44 and 65 /~g/g DM, respectively. The calibration equation utilized four terms, represented at wavelengths 1630, 2114, 2246, and 2356 nm. The spectra of commercial glucosamine were plotted, and reflectance peaks occurred at 2114 and 2356 nm. The validated equation was used to predict mold (chitin) in bales that had been visually estimated for mold with a relative mold index. Relative mold index was regressed
Finite-Time Consensus of Multiagent Systems With a Switching Protocol (2015)

In this paper, we study the problem of finite-time consensus of multiagent systems on a fixed directed interaction graph with a new protocol. Existing finite-time consensus protocols can be divided into two types: 1) continuous and 2) discontinuous, which were studied separately in the past. In this paper, we deal with both continuous and discontinuous protocols simultaneously, and design a centralized switching consensus protocol such that the finite-time consensus can be realized in a fast speed. The switching protocol depends on the range of the initial disagreement of the agents, for which we derive an exact bound to indicate at what time a continuous or a discontinuous protocol should be selected to use. Finally, we provide two numerical examples to illustrate the superiority of the proposed protocol and design method.
Effect of spinning parameters of polyethersulfone based hollow fiber membranes on morphological and mechanical properties (2018)

Hollow fiber (HF) membranes are gaining wide interest over flat membranes due to their compaction and high area to surface volume ratio. This work addresses the fabrication of HF from polysulfone (PS) and polyethersulfone (PES) using N-methylpyrrolidone (NMP) as solvent in addition to other additives to achieve desired characteristics. The semi-pilot spinning system includes jacketed vessel, four spinneret block, coagulation and washing baths in addition to dryer and winder. Different parameters affecting dry-wet spinning phase inversion process were investigated. Dope compositions of PES, NMP and polyvinyl pyrrolidone (PVP) of varying molecular weights as additive were addressed. Some critical parameters of importance were also investigated. Those include dope flow rate, air gap, coagulation & washing baths and drying temperatures. The measured dope viscosity was in the range from 1.7 to 36.5 Pa.s. Air gap distance was adjusted from 20 to 45 cm and coagulation bath temperature from 20 to 46oC.The HF membranes were characterized by scanning electron microscope (SEM), atomic force microscope (AFM) and mechanical properties. Results indicated prevalence of finger like structure and average surface roughness from about 29 to 78.3 nm. Profile of stress strain characteristics revealed suitability of the fibers for downstream interventions for fabrication of thin film composite membrane. Different empirical correlations were formulated which enable deeper understanding of the interaction of the above mentioned variables. Data of pure water permeability (PWP) confirmed that the fabricated samples fall within the microfiltration (MF)-ultrafiltration (UF) range of membrane separation.
[The autonomic nervous system and hypertension]. (2001)

It was shown that dysregulation of the cardiovascular system plays an important role in the development of arterial hypertension. Sympathetic drive can be increased mainly in cases of borderline and essential hypertension. The rise in sympathetic activity is not well balanced by the adequate increase in parasympathetic activity, even the PS tone is diminished. Relative sympathotony can occur beside the absolute sympathotony due to the decrease in the PS tone with normal or quantitatively less diminished sympathetic drive. The cause of the ANS activity dysbalance remains unknown. Probably there exist disorders of generator and modulator activities in higher levels of CNS, baroreceptor regulation and other peripheral (humoral and other) mechanisms. Adequate and appropriate recording of different cardiovascular parameters mainly during activation of ANS by maneuvers (orthostasis, Valsalva, etc.) is necessary. Beat-to-beat registrations of blood pressure (e.g. by Penáz method FINAPRES), heart rate (RR intervals) are necessary for the evaluation of short term blood pressure and heart rate fluctuations. Important information about S/PS activities and the balance in heart rate regulation can be achieved by spectral and non-linear analysis of the HR variability. Regular physical aerobic exercise increases the parasympathetic tone and is beneficial for restoration of the disordered S/PS balance in young hypertonics. It can be used as non-pharmacological treatment of arterial hypertension.
Broadband bias networks for pulse signal RF amplifiers (2015)

This article describes one possible solution of bias networks for special broadband RF amplifiers. The purpose is amplification special pulse signals from particle detectors, which demands well defined time domain properties. The problem is demonstrated on two basic prototypes with different amplifier chips used in. Both are designed using standard components with poor results and using special broadband inductors which gave much better results. At last, design and verification of the broadband inductors is presented.
Efficacy of Recombinant Methionyl Human Leptin Therapy for the Extreme Insulin Resistance of the Rabson-Mendenhall Syndrome (2004)

Recombinant methionyl human leptin (r-metHuLeptin) therapy has shown clear efficacy in the treatment of severe insulin resistance associated with lipodystrophy syndromes and low leptin levels. We treated two siblings with Rabson-Mendenhall syndrome (severe insulin resistance and presumed insulin receptor mutations). The brother and sister, aged 13 and 11 yr, respectively, had severe acanthosis nigricans, insulin resistance, and diabetes. Both were taking 2000 mg metformin and 2 mg rosiglitazone daily; the brother was also taking 300 U regular insulin daily. In contrast to our lipoatrophic patients treated with r-metHuLeptin, these two patients had a higher percent body fat and low-normal fasting triglycerides [42 mg/dl (0.37 mmol/liter), male sibling, and 33 mg/dl (0.47 mmol/liter), female sibling]. The siblings were treated with r-metHuLeptin therapy for 10 months and demonstrated a 40-60% decrease in fasting serum glucose and insulin levels and improved glycosylated hemoglobin. There was corresponding improvement in glucose and insulin tolerance during leptin therapy. This is the first report of a partial, but significant, effect of r-metHuLeptin administration in patients with extreme insulin resistance with a presumed insulin receptor mutation and low serum triglyceride levels.
Lineage infidelity in acute leukemia (1983)

Blast cells from 20 patients with acute leukemia (13 diagnosed myeloblastic and 7 as lymphoblastic, using the FAB classification) were studied using antibodies to lineage-specific differentiation markers. The phenotypic findings were usually consistent with the clinical diagnosis. However, examples were encountered where individual blast cells had a cytoplasmic marker of one lineage and a surface marker of a different lineage (lineage infidelity). Six examples of intramyeloid (two different myeloid lineages in the same cell) and three examples of interlineage infidelity (myeloid and lymphoid markers in the same blast cell) were encountered. No doubly marked cells were found in control material consisting of normal marrow cells, marrow regenerating after transplantation, or multilineage colonies derived from marrow in culture. A significant trend was observed relating the presence of lineage infidelity and failure of remission-induction. The data are interpreted as support for abnormal gene expression in leukemia.
Dramatic Response of Dropped Head Sign to Treatment with Steroid in Parkinson's Disease: Report of Three Cases (2011)

Neck dystonia is the most common cause of dropped head sign in parkinsonism. Isolated neck extensor myopathy, which is a rare condition, can also cause dropped head sign in parkinsonism, but no improvement has been achieved with immunosuppressive therapy. We report three cases of treatable neck extensor myopathy causing dropped head sign in patients with Parkinson's disease. Needle electromyography and magnetic resonance imaging suggested a restrictive active myopathy affecting neck extensor muscles. All cases responded dramatically to steroid therapy. Routine needle electromyography should be performed to explore treatable myopathy in Parkinson's disease.
Syndromes of Subacute Mountain Sickness (2004)

Two clinical syndromes, acute and chronic mountain sickness, have traditionally been associated with high altitude. Recently, two separate entities of subacute nature have been described in infants and adults. In this paper, we review the published literature on these conditions. Subacute infantile mountain sickness is a condition seen predominantly in Han Chinese infants living in Tibet, although it has been described in other high altitude communities as well. It came into prominence only after the large-scale migration of Chinese population from the low altitude of mainland China to the high altitudes of the Qinghai-Tibetan plateau. The condition is characterized by features of severe hypoxic pulmonary hypertension and heart failure. Pulmonary histology is consistent with muscularization of the pulmonary arterioles, but no intimal proliferation or plexiform lesions are seen. The second syndrome, adult subacute mountain sickness, has been described almost exclusively in Indian soldiers living at extreme altitude for prolonged periods of time. In this condition also, hypoxic pulmonary hypertension appears to be the dominant factor responsible for severe congestive heart failure. Both these conditions have several similarities with brisket disease in cattle; hypoxic pulmonary vasoconstriction plays an important role in the pathogenesis, and removal from high altitude results in complete resolution. Thus, it appears that both these syndromes are human counterparts of brisket disease in cattle.