gebhart/patrepeval huggingface dataset:
Transcriptional repression of apolipoprotein AI gene expression by orphan receptor ARP-1. (1994)

Expression of the apolipoprotein AI (apoAI) gene in the liver is controlled by a liver-specific enhancer. The function of this enhancer depends on synergistic interactions between transcription factors bound to at least three sites (designated A, B, and C) located within this enhancer. We have previously shown that an apoAI gene reporter construct containing the entire enhancer is expressed efficiently in a hepatoma cell line and that its activity is repressed by the orphan receptor ARP-1. Moreover, repression by ARP-1 is overcome by the retinoid X receptor RXR alpha in the presence of retinoic acid. In this study, we show that ARP-1 represses the apoAI promoter by binding to site A of the apoAI liver-specific enhancer, the repression being a promoter context-specific event. Mapping analysis of ARP-1 indicated that its DNA binding domain is essential but not sufficient for repression. Two separate repression domains located at the amino- and carboxyl-terminal halves of ARP-1 were found to individually complement the DNA binding domain for efficient repression. We also demonstrate the reversibility of ARP-1 repression by transcription factors C/EBP and Egr-1, which might also be involved in apoAI gene expression. Significantly, repression by ARP-1 was found to be a prerequisite for C/EBP-mediated transactivation. We interpret our results in terms of a model in which ARP-1 repression via its interaction with site A is an obligatory intermediate step in switching from one activated state of the apoAI gene to another.
Friction Reduction From Electrochemically Deposited Films (1991)

The lubricated sliding friction characteristics of both electrochemically precharged and uncharged piston ring specimens were determined m a laboratory friction apparatus. The iron phosphate films deposited on precharged piston ring specimens from a specific lubricant blend reduced both static and dynamic friction by as much as 25 to 35 percent. The mechanisms of friction reduction using electrochemically deposited films were investigated and interpreted in terms of surface roughness reduction and reaction film formation. The bulk metal properties influenced both the degree to which precharged films could be applied to a metal surface and the friction measured in a lubricated sliding contact. In addition, the friction characteristics and surface morphology of the iron phosphate films deposited on precharged piston ring specimens from a hydrocarbon-based medium were compared with those of traditional phosphate coatings made in an aqueous solution of phosphoric acid. The iron phosphate film deposited on precharged ring specimens consists of an amorphous structure and provides lower friction than does either traditional crystalline manganese or iron phosphate coatings.
Rapid Purification of Chemically Synthesized Oligodeoxy-Nucleotides (1985)

Abstract Advances in solid phase oligonucleotide synthesis have increased th number of sequences that can be synthesized within a short time. However, various deprotection steps are required for the isolation of the final products in a pure form. These work-up procedures are more time consuming than the synthesis itself.
Nonholonomic camera-space manipulation (1992)

The method of camera-space manipulation is extended to wheeled systems. A minimum of two cameras is required to place points on end-effectors (or objects in their grasp) of n-degree-of-freedom manipulators relative to other bodies where the nonholonomic degrees of freedom on a mobile manipulator base may be included. The target bodies do not have a precisely known location relative to the environment. The method is illustrated experimentally, though not in real time, using a point placement task. It is then generalized to rigid-body positioning tasks. Although the experimental point placement illustrations make use of a very simple trajectory planning scheme for the wheels of the base, a smoother optimal trajectory planning scheme that makes use of the Pontryagin maximum principle is also developed and illustrated. In a departure from the practice of using time as the independent variable for estimation and optimal trajectory planning algorithms, the present development is time independent and instead introduces the forward rotation of the drive wheel of the base as the independent variable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Two-level prediction-based reactive power coordination and voltage restoration strategy for microgrid (2017)

Voltage control is a fundamental requirement to ensure secure operation of microgrid, especially for islanded microgrid. This paper proposes a two-level reactive power coordination and voltage restoration strategy for microgird using model predictive control (MPC) approach. In supervisory level, reactive power set-point of each participating distributed generation source (DER) is calculated and distributed through communication link, while a droop based controller is utilized to control each participating DER to follow the reactive power set-point in primary level. One of the advantages of the proposed controller is that it takes system dynamic model into consideration to predict the possible voltage trajectory, the other is that the controller has the capability to calculate reactive power mismatch so as to coordinate each DER to provide reactive power compensation for voltage regulation. Simulation results show that the proposed controller is stable and effective to restore voltage to nominal after disturbances. Moreover, it can keep a smoother voltage profile in the presence of output variations of renewable sources.
Design of CML Ring Oscillators With Low Supply Sensitivity (2013)

The causes of supply noise-induced frequency variation in CML ring oscillators are investigated and a novel circuit topology that reduces the supply sensitivity is presented. It is shown that this technique causes only a slight reduction in the maximum oscillation frequency and maintains nearly the same random jitter generation while greatly reducing the sinusoidal jitter caused by power supply variation. Measurement results from a prototype chip fabricated in 0.18 μm CMOS process verify the effectiveness of the proposed technique.
Cloning and functional characterization of the UDP‐glucosyltransferase UgtB1 involved in sophorolipid production by <i>Candida bombicola</i> and creation of a glucolipid‐producing yeast strain (2010)

Sophorolipids produced by the non-pathogenic yeast Candida bombicola ATCC 22214 are glycolipid biosurfactants applied commercially as biodegradable and eco-friendly detergents. Their low cell toxicity, excellent wetting capability and antimicrobial activity attract the attention of high-value markets, such as the cosmetic and pharmaceutical industries. Although sophorolipid production yields have been increased by the optimization of fermentation parameters and feed sources, the biosynthetic pathway and genetic mechanism behind sophorolipid production still remains unclear. Here we identify a UDP-glucosyltransferase gene, UGTB1, with a key function in this economically important pathway. The protein shows sequence and structural homology to several bacterial glycosyltransferases involved in macrolide antibiotic synthesis. Deletion of UGTB1 in C. bombicola did not affect cell growth and resulted in a yeast producing glucolipids, thereby opening the route for in vivo production of these glycolipid intermediates. Activity assays on cell lysates confirmed that the identified gene is responsible for the second glucosylation step during sophorolipid production and illustrated that sophorolipid production in C. bombicola involves the stepwise action of two independent glucosyltransferases. The complete UGTB1 sequence data have been submitted to the GenBank database (http://www.ncbi.nlm.nih.gov) under Accession No. HM440974.
Ceramic Honeycomb Panels (1989)

Ceramic honeycomb panels serve as lightweight, heat-resistant structural members. Depending on choice of ceramic materials, panels expected to withstand temperatures as high as 1,800 degree C. Honeycomb structure made by vapor-depositing ceramic on fabric substrate woven in honeycomb pattern, then eliminating substrate by oxidizing it. Fabric made of loosely woven polymer such as polyacrylonitrile. Impregnated with organic binder such as phenolic resin for stiffness.
Ultrasonic pulse‐echo determination of thermal injury in deep dermal burns (1977)

Burns of all kinds represent a serious class of traumatic injury, affecting over two million people annually in the United States alone. Of this number, over 70000 are serious enough to require extended hospitalization. Currently, there is no sensitive, quantitative technique for measuring the depth of thermal damage in such injuries. An ultrasonic pulse-echo technique is described here whereby such information can be obtained within a few minutes postburn. Results from model porcine experiments are given to illustrate the usefullness of the method, and implication for the clinical care of human burn victims are discussed.
Gram-scale, high-yield synthesis of a robust metal–organic framework for storing methane and other gases (2013)

We have synthesized and characterized a new metal–organic framework (MOF) material, NU-125, that, in the single-crystal limit, achieves a methane storage density at 58 bar (840 psi) and 298 K corresponding to 86% of that obtained with compressed natural gas tanks (CNG) used in vehicles today, when the latter are pressurized to 248 bar (3600 psi). More importantly, the deliverable capacity (58 bar to 5.8 bar) for NU-125 is 67% of the deliverable capacity of a CNG tank that starts at 248 bar. (For crystalline granules or powders, particle packing inefficiencies will yield densities and deliverable capacities lower than 86% and 67% of high-pressure CNG.) This material was synthesized in high yield on a gram-scale in a single-batch synthesis. Methane adsorption isotherms were measured over a wide pressure range (0.1–58 bar) and repeated over twelve cycles on the same sample, which showed no detectable degradation. Adsorption of CO2 and H2 over a broad range of pressures and temperatures are also reported and agree with our computational findings.
Effect of Mineral Additives CSA Cement on the Properties and Hydration of Portland Cement Blends (2016)

The influence of the physical properties,hydration process and products of Portland cement doped with different particle size and content of calcium sulphoaluminates cement(CSA cement) were studied with three different particle size of CSA cement as mineral admixture.Research shows that the content and particle size of CSA cement both effect the setting time and water requirement of normal consistency of PC,when PC blends with little content of CSA cement(1%),the compressive strength has improved,CSA cement shorten the induction period of PC hydration,promote the early hydration,reduce the hydration rate of C3 S and speed up the AFt to AFm.CSA cement increases the total porosity,cumulative pore volume and the most probable aperture of early hydrated paste,but little effect on later hydrated,morphology of AFt and CH,such as short acicular fiber AFt and large-sized hexagonal plateCH against the living and combination of crystals,has greater impact on compressive strength.
Holographic CDMA (1995)

A new technique for all-optical code division multiple access (CDMA) based on optical holography is described. In this technique the energy of an incoming information light signal is spread over a larger spatial domain by a two-dimensional spatial encoder which consists of patterns of (0, 1) or (1, -1). Subsequent decoding, which is obtained by a holographic filter, spatially despreads the energy of information light signal and brings it to a bright focused light spot. Experimental results obtained to demonstrate the encoding, decoding, and multiaccess capability of the proposed holographic CDMA technique are discussed and compared to other all-optical CDMA techniques. The processing gain for a holographic CDMA can be potentially as high as 10/sup 6/-10/sup 8/, which suggests that this technique can in principle support hundreds of thousands to a few millions of users.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Design and performance of the micro-dose calibrator (2018)

A new class of dose calibrator called a micro-dose calibrator, designed to measure radioactivity rates in the range between 1 kBq up to 370 kBq, has been designed and an 8 NaI(Tl)/photo multiplier tube (PMT) module prototype built to evaluate its performance. The design of the micro-dose calibrator is based on the concept of a segmented well counter. By segmenting a single crystal well counter into multiple crystals or segments, with each segment operated and read out independently, one can extend the operational range of a standard single crystal well counter while maintaining its accuracy and spectrographic capabilities. The micro-dose calibrator is operated in N-fold coincidence mode to ensure that a single radioactive decay resulting in multiple segments detecting gamma ray events are counted as a single decay. The N fold coincidence detection is achieved using a pipeline coincidence processing algorithm implemented in software as part of a multi-threaded acquisition system. A tri-functional model pulse pileup dead time correction is applied to extend the operational range of the micro-dose calibrator. The micro-dose calibrator achieved an operation range between 1 kBq up to 3.4 MBq for <sup>18</sup>F with a 1% linearity precision using a 60 s integration time window. Over a 9 d period, a daily count rate measure of a <sup>137</sup>Cs point source had a coefficient of variation of 0.17% with only one high voltage calibration performed on day 0. The central 20 mm up to 35 mm axial length in the sample well showed less than 1% change in count rate depending on the radionuclide. Using a 0.5 ml insulin syringe, a volume of dose between 0.13 ml up to 0.50 ml showed less than 1% deviation from volumetric linearity. A 20 cc scintillation vial showed similar volumetric linearity performance for radionuclide solution volumes between 4 cc up to 20 cc.
A New Photovoltaic Cell (1994)

Abstract This study describes a photovoltaic cell whose design does not require any additional sources of electric power. The said cell comprises a charge carrier film of a polar polymer. Typically, useful polymers are poly (ethylene terephthalate), polyamide, penton (viz., poly-3, 3-bis- (chloromethyl) oxethane), poly (vinyl butyral). The cell has, on both faces, conducting electrodes of metals whose electrochemical potentials differ by at least 0.8 V. The front electrode has a discrete coating, in the form of hemispheres, which is made of absorptive polymer material. In addition, the film charge carrier can be reinforced with a metallic grid whose electrochemical potential differs from those of the electrodes. Key Words: Photovoltaic materialspolymersfilms.
Monoclonal antibodies to protease nexin 1 that differentially block its inhibition of target proteases (1988)

Protease nexin 1 (PN-1) is a protease inhibitor secreted by cultured fibroblasts that forms complexes with certain serine proteases; the complexes bind back to the cells and are internalized and degraded. In the present studies, a panel of PN-1 monoclonal antibodies (mAbs) was isolated; none showed detectable cross-reactivity with four related plasma protease inhibitors. Four purified mAbs (mAbp1, mAbp6, mAbp9, and mAbp18) were tested for their ability to block the formation of complexes between PN-1 and target proteases. mAbp1, as well as a rabbit polyclonal anti-PN-1 IgG preparation, did not block formation of 125I-thrombin-PN-1 complexes. mAbp6, mAbp9, and mAbp18 blocked the formation of 125I-thrombin-PN-1 and 125I-urokinase-PN-1 complexes at stoichiometric concentrations of mAb and PN-1. Studies on their ability to block formation of 125I-trypsin-PN-1 complexes showed that mAbp18 also blocked this reaction at stoichiometric concentrations with PN-1 whereas mAbp6 and mAbp9 blocked less effectively. Thus, mAbp18 appears to bind at or close to the reactive center of PN-1. The blocking mAbs should be useful in studies to probe physiological functions of PN-1.
Integrated CMOS surface acoustic wave gas sensor: design and characteristics (2004)

The development of inexpensive and miniaturized Surface Acoustics Wave (SAW) gas sensors that are highly selective and sensitive is described. These sensors are implemented with micro-electro-mechanical systems (MEMS) in CMOS technology. IDT equivalent circuit and model for SAW delay line is introduced. Simulation results are included for characterization and design of the sensor. In this paper we will describe the design and post-processing steps to implement SAW device in CMOS technology. Design parameters of this device were obtained using modeling equivalent circuit to characterize sensor. Two approaches were used in the design of the SAW gas sensor that will be discussed. A CMOS chip was fabricated using MOSIS. Thin film ZnO was grown on Silicon based die and its characterizations is presented.
Development of a Passive and Slope Adaptable Prosthetic Foot (2017)

Historically, users of prosthetic ankles have relied on actively operated systems to provide effective slope adaptability. However, there are many drawbacks to these systems. This research builds upon work previously completed by Hansen et al. as it develops a passive, hydraulically operated prosthetic ankle with the capability of adapting to varying terrain in every step. Using gait cycle data and an analysis of ground reaction forces, the team determined that weight activation was the most effective way to activate the hydraulic circuit. Evaluations of the system pressure and energy showed that although the spring damper system results in a loss of 9J of energy to the user, the footplate stores 34J more than a standard prosthesis. Therefore, the hydraulic prosthetic provides a 54% increase in stored energy when compared to a standard prosthesis. The hydraulic circuit manifold prototype was manufactured and tested. Through proof of concept testing, the prototype proved to be slope adaptable by successfully achieving a plantarflexion angle of 16 degrees greater than a standard prosthetic foot currently available on the market.
Evidence for leptin receptor isoforms heteromerization at the cell surface (2010)

Leptin mediates its metabolic effects through several leptin receptor (LEP-R) isoforms. In humans, long (LEPRb) and short (LEPRa,c,d) isoforms are generated by alternative splicing. Most of leptin's effects are believed to be mediated by the OB-Rb isoform. However, the role of short LEPR isoforms and the possible existence of heteromers between different isoforms are poorly understood. Using BRET1 and optimized co-immunoprecipitation, we observed LEPRa/b and LEPRb/c heteromers located at the plasma membrane and stabilized by leptin. Given the widespread coexpression of LEPRa and LEPRb, our results suggest that LEPRa/b heteromers may represent a major receptor species in most tissues.
Passively cooled pump signal combiners at 2.1 kW for fiber laser and amplifier systems (2020)

In this work we demonstrate, a high brightness, high transmission Pump Signal Combiner (PSC) operating at 2.1 kW for 10 minutes mounted on a metal plate without running cooling water (Passively Cooled). The 6+1 to 1 PSC tested in this work has six 247 μm cladding diameter 0.22NA pump pigtails, a 10/125um signal pigtail and a 20/400um double clad output fiber. The combiners achieve a high pump transmission efficiency of 98%. During the passively cooled highpower test conducted at a power of 2.1 kW the maximum temperature recorded on the surface of the package was at a temperature of 38.5°C for 10min of power aging.
Automatic stent detection in intravascular OCT images using bagged decision trees (2012)

Intravascular optical coherence tomography (iOCT) is being used to assess viability of new coronary artery stent designs. We developed a highly automated method for detecting stent struts and measuring tissue coverage. We trained a bagged decision trees classifier to classify candidate struts using features extracted from the images. With 12 best features identified by forward selection, recall (precision) were 90%-94% (85%-90%). Including struts deemed insufficiently bright for manual analysis, precision improved to 94%. Strut detection statistics approached variability of manual analysis. Differences between manual and automatic area measurements were 0.12 ± 0.20 mm(2) and 0.11 ± 0.20 mm(2) for stent and tissue areas, respectively. With proposed algorithms, analyst time per stent should significantly reduce from the 6-16 hours now required.
A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents (2011)

We investigated the antimicrobial activities of N-substituted glycine "peptoid" oligomers incorporating cationic and hydrophobic side chains. Head-to-tail macrocyclization was employed to enhance antimicrobial activity. Both linear and cyclic peptoids, ranging from six to ten residues, demonstrate potent antimicrobial activity against Gram-positive and Gram-negative bacteria. These peptoids do not cause significant lysis of human erythrocytes, indicating selective antimicrobial activity. Conformational ordering established upon macrocyclization is generally associated with an enhanced capacity to inhibit bacterial cell growth. Moreover, increased hydrophobic surface area also plays a role in improving antimicrobial activity. We demonstrate the potency of a cyclic peptoid in exerting antimicrobial activity against clinical strains of S. aureus while deterring the emergence of antimicrobial resistance.
Experimental and numerical characterization of the narrow channel Hall thruster discharge (2021)

A sub-30 W Hall effect thruster known as the Narrow Channel Hall Thruster (NCHT) was recently developed at the Aerospace Plasma Laboratory, Technion. In this work, the near field plume region of the NCHT is analyzed using emissive and planar Langmuir probes. The NCHT discharge is also analyzed using a particle-in-cell simulation, capable of providing 2D spatial distributions of the plasma parameters inside the channel itself. Both experimental and simulation results confirm that most of the potential drop ∼60% occurs outside the channel. The results also show that ion current loss to the walls and anode is substantial, similar in value of the ion beam current itself.
Linkage of a new locus for autosomal dominant familial spastic paraplegia to chromosome 2p (1994)

Autosomal dominant familial spastic paraplegia (AD-FSP) is a genetically heterogeneous neurodegenerative disorder characterized by a spasticity of the lower limbs. A locus causing AD-FSP (FSP1) has been previously mapped to chromosome 14q. We now report linkage of a second AD-FSP locus (FSP2) to chromosome 2p21-p24 in five of seven French families and one large Dutch pedigree. The analysis of recombination events and multipoint linkage place FSP2 within a 4 cM interval flanked by loci D2S400 and D2S367.
Synthesis and antiinflammatory activity of some 1,2,3- and 1,2,4-triazolepropionic acids (1978)

All possible "nonadjacent" phenyltriazolepropionic acids were synthesized and tested for antiinflammatory activity. Two of the isomers displayed activity approximately equal to phenylbutazone: the 4-phenyl-1,2,3,-triazole-2-propionic acid (7) and its reverse counterpart, 2-phenyl-1,2,3-triazole-4-propionic acid (6). The other five isomers were inactive. Since these seven acids are geometrically congruent and possess similar lipophilic characters, antiinflammatory activity must depend on some property that is a function of how the carbon and nitrogen atoms are arranged in the triazole ring.