gebhart/patrepeval huggingface dataset:
Nanofiber Alignment Regulates NIH3T3 Cell Orientation and Cytoskeletal Gene Expression on Electrospun PCL+Gelatin Nanofibers (2016)

To examine the influence of substrate topology on the behavior of fibroblasts, tissue engineering scaffolds were electrospun from polycaprolactone (PCL) and a blend of PCL and gelatin (PCL+Gel) to produce matrices with both random and aligned nanofibrous orientations. The addition of gelatin to the scaffold was shown to increase the hydrophilicity of the PCL matrix and to increase the proliferation of NIH3T3 cells compared to scaffolds of PCL alone. The orientation of nanofibers within the matrix did not have an effect on the proliferation of adherent cells, but cells on aligned substrates were shown to elongate and align parallel to the direction of substrate fiber alignment. A microarray of cyotoskeleton regulators was probed to examine differences in gene expression between cells grown on an aligned and randomly oriented substrates. It was found that transcriptional expression of eight genes was statistically different between the two conditions, with all of them being upregulated in the aligned condition. The proteins encoded by these genes are linked to production and polymerization of actin microfilaments, as well as focal adhesion assembly. Taken together, the data indicates NIH3T3 fibroblasts on aligned substrates align themselves parallel with their substrate and increase production of actin and focal adhesion related genes.
Inverted Calot’s Triangle and Associated Vascular Variations. (2017)

This report describes the concurrent vascular and ductal variations of the hepatobiliary system. The right hepatic artery arose directly from the common hepatic artery, passed through the Calot’s triangle and entered the right lobe of the liver through the gall bladder fossa. The left hepatic artery arose from a common gastrohepatic trunk and entered the left lobe of the liver through fissure for ligamentum venosum. It gave two esophageal branches before entering the liver. The cystic duct was broad, straight and opened on the left side of the common hepatic duct, thus giving a mirror image appearance to the Calot’s triangle. This report is likely to be the first on such combined variations at the vicinity of the liver.
UltiMOS: A local charge-balanced trench-based 600V super-junction device (2011)

This paper for the first time reports on a novel “local” charge balanced trench-based super junction transistor. The local charge balance is achieved by selectively growing thin highly-doped n-type and p-type layers in a deep trench structure. The final charge-balanced trench structure is finished with an oxide-sealed airgap. Devices rated at 10A with V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">bd</sub> =730V and a Ron=23 mΩ.cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> are demonstrated.
Liver-Enriched Transcription Factors Regulate MicroRNA-122 That Targets CUTL1 During Liver Development (2010)

Our study provides a model in which miR-122 functions as an effector of LETFs and contributes to liver development by regulating the balance between proliferation and differentiation of hepatocytes, at least by targeting CUTL1.
Importance of antibody isotype in monoclonal anti-idiotype therapy of a murine B cell lymphoma. A study of hybridoma class switch variants. (1986)

An initial panel of four syngeneic monoclonal antibodies directed against the idiotype of a murine B cell lymphoma was used to treat this tumor in vivo. The antibody in the panel of the IgG2a isotype was more effective in treatment than the other antibodies, which were of the IgG1 and IgG2b isotypes. To independently assess the role of antibody isotype in mediating antitumor effects, switch variant hybridoma families were isolated from the hybridomas secreting the less effective IgG1 and IgG2b antibodies. A family isolated from an IgG1-secreting parent consisted of IgG1-, IgG2b-, and IgG2a-secreting members, and an IgG2a variant was isolated from an IgG2b-secreting parent for another family. Antibody members of each family differed only in heavy chain composition and were the same with respect to their light chains and their affinity and specificity for idiotype. The IgG2a members of both families were superior to the other members in inhibiting tumor growth with an order of effectiveness of IgG2a greater than IgG1 greater than IgG2b. These in vivo results paralleled the abilities of these different isotype antibodies to mediate antibody-dependent cellular cytolysis in vitro. For the IgG2b----IgG2a family, in vivo treatment with the IgG2a member given i.p. after i.p. tumor challenge at one-tenth the dose of the IgG2b member was still superior to the latter. At one-hundredth the dose of the IgG2b, the IgG2a was still superior to the latter when the antibodies were given i.p. and tumors subcutaneously. These data and those showing that the clearance of these antibodies from the serum differed in only a relatively minor way indicate that the IgG2a antibodies in this system had greater antitumor effects primarily by virtue of their greater capacity for host effector interaction.
Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways (2012)

These results clearly demonstrate that the PSE extact displays growth-suppressive activity and induces apoptosis in AGS cells. Our data suggest that the PSE extact might be a potential anti-cancer agent for gastric cancer.
Machine Learning as a Reliable Technology for Evaluating Time/Rate Performance of Unconventional Wells (2016)

Summary Production-data analysis is a practice fraught with inconsistencies. In the application of any single model, the quantity of answers arrived at by experienced evaluators is often equal to the number of evaluators analyzing the data. The cause of such inconsistency is bias on the part of evaluators. Although the colloquial use of bias typically implies systematic error, in this paper, we define bias as an expression of belief by the evaluator. With the lack of recognition of bias, no means exists with which to gauge its accuracy. A method that requires explicit expression of one's bias in time/rate decline behavior can provide an objective means with which to evaluate it. In this work, we present a machine-learning method to forecast production in unconventional, liquid-rich shale and gas-shale wells. Methods were developed for probabilistic decline-curve analysis with Markov-chain Monte Carlo simulation (MCMC) as a means to quantify reserves uncertainty, to incorporate prior information (i.e., bias), and to do so quickly. We extend the existing approaches by (a) a modified likelihood-distribution function to improve “learning” of production data, (b) integration of the transient hyperbolic model (THM) to explicitly define the various flow regimes present in unconventional wells, (c) a method for construction of discretized “percentile neighborhood” forecasts, and (d) construction of type wells from an analyzed well population. The accuracy and calibration of the method are demonstrated by an analysis of 136 wells in the Elm Coulee Field of the Bakken. Quantification of change in time/rate behavior caused by completion design, and the inference of physical behavior and properties, is demonstrated with a tight oil play in the Cleveland sand formation of the Anadarko Basin, as well as a shale play in the Wolfcamp formation of the Permian Basin. We show that this implementation of supervised machine learning, in combination with well-calibrated bias, improves the estimation of uncertainty of the posterior distribution of forecasts. In addition, hindcasts performed at various time intervals result in accurate estimation of mean five-year cumulative production. We observe that the “percentile neighborhood” forecasts are reasonable fits of production data comparable to those that may be created by a human evaluator, and that the type well computed is representative of the decline behavior of the well population upon which it is based. We conclude that, given the speed and accuracy of the process, machine learning is a reliable technology as defined by the US Securities and Exchange Commission (SEC), and can significantly improve the process of production forecasting by human evaluators for most unconventional wells with consistent trends of production history.
1‐alkylcyclopropanecarboxylates: An extension of pyrethroid structure—activity relationships (1976)

Abstract 1‐Alkylcyclopropanecarboxylic acids are synthesised by thermolysis of 1‐pyrazolines prepared by 1,3‐dipolarcycloadditions of diazoalkanes. The insecticidal and acaricidal activities of 14 pyrethroid esters of these acids are considered in relation to the influence of steric and metabolic factors on activity. 1‐Alkyl compounds are less active than esters with no alkyl group at position 1, contrary to expectations, and also less active than the corresponding 2‐alkyl esters.
Applying the intentional forgetting process to forgiveness. (2015)

Abstract The current research tests the hypothesis that the cognitive process of intentional forgetting can be applied to promote forgiveness. In three experiments, participants read stories set in second person point of view sentence by sentence. Each story included a target conflict sentence. After each sentence, participants saw a cue indicating forget or remember (Experiment 1, n = 89) or important or not important (Experiment 2, n = 123) or control cue (Experiment 3, n = 198). Findings revealed that, among participants who remembered the transgression, being told to intentionally forget the transgression led to increased forgiveness (Experiments 1 & 3). However, being told that the transgression was not important had no effect on forgiveness (Experiment 2). Overall, results are consistent with the hypothesis that an active process of intentional forgetting (as opposed to a passive process of disregarding unimportant information) can promote forgiveness. The interpersonal and clinical applications of these findings are discussed.
Study of Natural Convection MHD Nanofluid by Means of Single and Multi-Walled Carbon Nanotubes Suspended in a Salt-Water Solution (2015)

The natural convection boundary layer flow along a vertical cone with variable wall temperature under the presence of magnetohydrodynamics is investigated. The mathematical model based on nanolayer single and multi-wall carbon nanotubes in salt-water solutions and interfacial layers is considered. The nonlinear partial differential equations are analytically solved by means of Mathematica package BVPh 2.0 based on the homotopy analysis method. Flow behavior under altering involving physical parameters such as: Eckert number, Prandtl number, power law index, and nanoparticle volume fraction on the velocity and the temperature profiles is discussed and explained through graphs and tables. The values of Skin friction and Nusselt number are computed and examined.
Effect of Lipoxygenase on the Oxidation of Rainbow Trout Lipid in Model system (1995)

The effect of lipoxygenase (LOX) on the oxidation and co-oxidation of lipid fraction was studied in the model system of rainbow trout. For the reaction in model system 1 g of lipid fraction and 50mL of enzyme extract(LOX, 140 unit in 50mL phosphate buffer solution at pH 7,4)), which were obtained from rainbow trout, were homoginized in the presence of Tween 20 and kept at 23$\circ$C for 3 days. The activity of LOX was decreased to 43% of initial level during the reaction in the model system. The initial composition of rainbow trout lipid was showed to be consisted of trigliceride(TG;82%) and free fatty acid(FFA;0.1%), while this converted to 59% of TG and 20% of FIFA, respectively after reaction in model system. Change of fatty acid composition was also observed and the content of linoleic acid, one of the major fatte acids, was decreased to 13% from 54% in the content of total fatty acids after reaction. The carotenoids in rainbow trout were composed of 0.4% $\alpha$-carotene, 1.6% $\beta$ -carotene, 80% canthaxanthin, 7% lutein and 11% zeaxanthin, thus the canthaxanthin was the major component. This canthaxanthin was the most degraded carotenoid by lipoxygenase catalyzed co-oxidation during the reaction. On the other hand the tocopherol isomers found in the rainbow trout were $\alpha$ and $\beta$ -tocopherol, and $\alpha$-tocopherol had a higher degradation rate by the lipoxygenase catalyzed co-oxidation than of $\beta$-tocopherol in the reaction of model system.
Definition of the First Mannosylation Step in Phosphatidylinositol Mannoside Synthesis (2002)

We examined the function of the pimA (Rv2610c) gene, located in the vicinity of the phosphatidylinositol synthase gene in the genomes of Mycobacterium tuberculosis and Mycobacterium smegmatis, which encodes a putative mannosyltransferase involved in the early steps of phosphatidylinositol mannoside synthesis. A cell-free assay was developed in which membranes from M. smegmatis overexpressing the pimA gene incorporate mannose from GDP-[(14)C]Man into di- and tri-acylated phosphatidylinositol mono-mannosides. Moreover, crude extracts from Escherichia coli producing a recombinant PimA protein synthesized diacylated phosphatidylinositol mono-mannoside from GDP-[(14)C]Man and bovine phosphatidylinositol. To determine whether PimA is an essential enzyme of mycobacteria, we constructed a pimA conditional mutant of M. smegmatis. The ability of this mutant to synthesize the PimA mannosyltransferase was dependent on the presence of a functional copy of the pimA gene carried on a temperature-sensitive rescue plasmid. We demonstrate here that the pimA mutant is unable to grow at the higher temperature at which the rescue plasmid is lost. Thus, the synthesis of phosphatidylinositol mono-mannosides and derived higher phosphatidylinositol mannosides in M. smegmatis appears to be dependent on PimA and essential for growth. This work provides the first direct evidence of the essentiality of phosphatidylinositol mannosides for the growth of mycobacteria.
Comparison of glucose conversion to 5-HMF using different modified mordenites in ionic liquid and biphasic media (2016)

Modified mordenites have been used in the direct conversion of glucose into 5-hydroxymethylfurfural (5-HMF) in two different media: the ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIM]Br) and a biphasic system composed of water–acetone and ethyl acetate.
Drogas anfetamínícas de diseño. Revisión toxicológica (1994)

Desde hace unos anos se ha venido incremen 
tando en Espana el consumo e incautacion de nuevas 
drogas de diseno, en especial derivados anfetaminicos. En 
el presente articulo se resumen los principales aspectos toxicocineticos y dinamicos, sus efectos toxicos y tratamien 
to, asi como los medios de deteccion mas frecuentes y 
utiles. Todo ello referido, fundamentalmente, a la metilendioxianfetamina y metilendioximetanfetamina, hasta el 
momento, y segun las determinaciones practicadas en el 
Instituto Nacional de Toxicologia, las mas frecuentes ana 
lizadas en nuestro pais.
Selegiline Is Ineffective in a Collaborative Double-blind, Placebo-Controlled Trial for Treatment of Amyotrophic Lateral Sclerosis (1998)

Selegiline treatment had no significant effect on the rate of clinical progression or outcome of ALS.
Are diverse signalling pathways integrated in the regulation of <i>Arabidopsis</i> antioxidant defence gene expression in response to excess excitation energy? (2000)

When low-light-grown Arabidopsis rosettes are partially exposed to excess light (EL), the unexposed leaves become acclimated to excess excitation energy (EEE) and consequent photo-oxidative stress. This phenomenon, termed systemic acquired acclimation (SAA), is associated with redox changes in the proximity of photosystem II, changes in foliar H2O2 content and induction of antioxidant defences. The induction of extra-plastidial antioxidant systems is important in the protection of the chloroplast under EL conditions. A larger range of transcripts encoding different antioxidant defence enzymes may be induced in the systemically acclimated leaves and these include those encoded by the glutathione peroxidase (GPX2) and glutathione-S-transferase (GST) genes, which are also highly induced in the hypersensitive response and associated systemic acquired resistance (SAR) in incompatible plant-pathogen interactions. Furthermore, the expression of the SAR-inducible pathogenesis-related protein gene, PR2, is enhanced in SAA leaves. Wounded leaf tissue also shows enhanced systemic induction of a cytosolic ascorbate peroxidase gene (APX2) under EL conditions. These and other considerations, suggest H2O2 and other reactive oxygen species (ROS) could be the common factor in signalling pathways for diverse environmental stresses. These effects may be mediated by changes in the level and redox state of the cellular glutathione pool. Mutants with constitutive expression of a normally EL-inducible APX2 gene have much reduced levels of foliar glutathione. The expression of APX1 and APX3, encoding cytosolic and peroxisome-associated isoforms, respectively, are also under phytochrome-A-mediated control. The expression of these genes is tightly linked to the greening of plastids in etiolated seedlings. These data suggest that part of the developmental processes that bring about the acclimation of leaves to high light includes the configuration of antioxidant defences. Therefore, the linkage between immediate responses of leaves to EL, acclimation of chloroplasts to EEE and the subsequent changes to leaf form and function in high light could be mediated by the activity of foliar antioxidant defences and changes in the concentration of ROS.
Radiation Effects in Carbon Nanoelectronics (2012)

We experimentally investigate the effects of Co-60 irradiation on the electrical properties of single-walled carbon nanotube and graphene field-effect transistors. We observe significant differences in the radiation response of devices depending on their irradiation environment, and confirm that, under controlled conditions, standard dielectric hardening approaches are applicable to carbon nanoelectronics devices.
Binding Constants for Terbium( (2001)

［1］Aisen, P., Liebman, A. and Zweier, J., J. Biol. Chem., 253, 1 930(1978) ［2］Martin, R. B., Savory, J., Brown, S., et al., Clin. Chem., 33, 405(1987) ［3］Baker, E. N., in Advances in Inorganic Chemistry, 11, 389(1994) ［4］Kurokawa, H., Mikami, B. and Hirose, M., J. Mol. Biol., 254, 196(1995) ［5］Baldwin, D. A. and Egan, T. J., S. Afr. J. Sci., 83, 22(1987) ［6］Yang Bin-sheng and Harris, W. R., Chinese. J. Biochem. Mol. Biol., 15, 462(1999) ［7］Harris, W. R. and Chen, Y., Inorg. Chem., 31, 5 001(1992) ［8］Chasteen, N. D. and Williams J., Biochem. J., 193, 717(1981) ［9］Martell, A. E. and Smith, R. M., Critical Stability Constants, Plenum, New York, 1974 ［10］Yang Bin-sheng and Harris W. R., Acta Chimica Sinica, 57, 503(1999) ［11］Williams, J. and Evans, R. W., Proteins of Iron Metabolism, Grune and Stratton, New York, 169(1977) ［12］YANG Bin-sheng and Harris, W. R., Chem. J. Chinese Universities, 19, 1 057(1998) ［13］Abdollahi, S. and Harris, W. R., J. Phys. Chem., 100, 1 950(1996)
The Use of a Monoclonal Antibody Specific for the N-terminal Region of Southern Bean Mosaic Virus as a Probe of Virus Structure (1986)

Summary The N-terminal cyanogen bromide peptide of the coat protein of the cowpea strain of southern bean mosaic virus (SBMV-C) was purified by high-pressure liquid chromatography and used as an immunogen in the production of monoclonal antibodies. One monoclonal antibody, designated 4D6, bound to both purified peptide and immobilized virus in a solid-phase ELISA. The reactivity of this monoclonal antibody with immobilized peptide could not be inhibited by native SBMV-C but was inhibited by low levels of EDTA-swollen virus in an antigen inhibition ELISA. The binding of 4D6 to the swollen conformation of the virus was not significantly diminished upon collapsing the swollen virus by pH adjustment or addition of calcium ions. Reactivity of the antibody was also observed with native virus particles which had been dialysed against weakly alkaline buffers. The binding of 4D6 was extremely sensitive to trypsin proteolysis of the virus coat protein, indicating that the antibody binding site was most likely located within the first 30 amino acid residues of the N-terminus. Monoclonal antibody 4D6 also cross-reacted weakly with red clover necrotic mosaic virus in both indirect ELISA and antigen inhibition ELISA.
A Statistical Model of Human Pose and Body Shape (2009)

Abstract Generation and animation of realistic humans is an essential part of many projects in today's media industry. Especially, the games and special effects industry heavily depend on realistic human animation. In this work a unified model that describes both, human pose and body shape is introduced which allows us to accurately model muscle deformations not only as a function of pose but also dependent on the physique of the subject. Coupled with the model's ability to generate arbitrary human body shapes, it severely simplifies the generation of highly realistic character animations. A learning based approach is trained on approximately 550 full body 3D laser scans taken of 114 subjects. Scan registration is performed using a non‐rigid deformation technique. Then, a rotation invariant encoding of the acquired exemplars permits the computation of a statistical model that simultaneously encodes pose and body shape. Finally, morphing or generating meshes according to several constraints simultaneously can be achieved by training semantically meaningful regressors.
Iodide and iodine determination in the parts-per-billion range with leuco crystal violet and N-chlorosuccinimide-succinimide reagents (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIodide and iodine determination in the parts-per-billion range with leuco crystal violet and N-chlorosuccinimide-succinimide reagentsJack L. Lambert, Gary L. Hatch, and Benjamin. MosierCite this: Anal. Chem. 1975, 47, 6, 915–916Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/ac60356a010https://doi.org/10.1021/ac60356a010research-articleACS PublicationsRequest reuse permissionsArticle Views399Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts