gebhart/patrepeval huggingface dataset:
Quotient space granular computing for the Click-stream data warehouse in Web servers (2010)

The quotient space granular computing's normalized equicrual metric and the combination of domains are used to the mining web log data pre-processing stage before creating click-stream data warehouse. From visiting the web page, to analyze the sites and the paths of interest for users, the better access to the site behavior for users can be obtained, building the best network topology structure. According to calculation, the performance of the Click-stream data warehouse (CDW) can be improved effectively by this way.
The decipher speech recognition system (2002)

A large-vocabulary, continuous-speech system, called DECIPHER, which is based on a hidden Markov model (HMM) approach and is designed to achieve high word accuracy in a speaker-independent mode is described. The results of a series of experiments that test acoustic and phonological adaptation of the DECIPHER system to the pronunciations of a single speaker in a speaker-dependent task are presented. Estimating the probabilities of alternative pronunciations and speaker-dependent phonology are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Size‐exclusion chromatography coupled to multiangle light scattering detection of long‐chain branching in polyethylene made with phillips catalyst (2011)

Abstract Size‐exclusion chromatography coupled to multiangle light scattering (SEC‐MALS) has been used to detect long‐chain branching (LCB) in polyethylene (PE) from Cr/silica catalysts for the first time. The observed LCB response to several catalyst and reactor variables mostly confirms earlier conclusions drawn from rheological measurements. However, SEC‐MALS has also shed additional light on a few previously unanswered questions. Above all, SEC‐MALS shows the placement of branching within the MW distribution, which was not previously known, and which may explain some of the unique molding behavior of Cr‐derived PE. This new SEC‐MALS data also provide insight into the mechanism of LCB formation, which is discussed. Like earlier studies based on rheology, this new study demonstrates that the commonly accepted view of macromer incorporation may be overly simplistic. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Identification and Characterization of Variants of Tick Anticoagulant Peptide with Increased Inhibitory Potency toward Human Factor Xa (1995)

Tick anticoagulant peptide (TAP) is a specific and potent inhibitor of factor Xa (fXa), a central enzyme in the blood clotting cascade. As such, TAP is a potential antithrombotic agent. Site-directed mutagenesis studies were undertaken to determine the feasibility of increasing the inhibitory potency of TAP toward fXa. The amino acid substitutions Tyr-1 to Trp (Y1W) and Asp-10 to Arg (D10R) increased inhibitory potency toward human fXa by 2.5- and 4-fold, respectively. The increased inhibitory potency reflected a decrease in the rate constant for dissociation of the final fXa-TAP inhibitory complex. The double mutant, Y1W/D10R, exhibited an inhibition constant of 10 pM, a 37-fold enhancement of inhibitory potency toward human fXa. The improvement in inhibitory potency was less pronounced (12-fold) with dog fXa wherein Kis of 220 and 18 pM were observed for wild-type TAP and the double mutant, respectively. Mutation of Tyr-1 to Glu (Y1E) generated a weaker inhibitor (Ki = 2 nM) that bound human fXa more slowly. However, no change in inhibitory potency toward human fXa was observed when Tyr-1 was replaced by Phe. Taken together, these observations are consistent with the view that a hydrophobic amino acid at the N-terminus of TAP may be a determinant of inhibitory potency. Decreases by 3-4 orders of magnitude in inhibitory potency were noted upon mutation of Asn-2 and Leu-4 of TAP, further implicating the N-terminal domain as an important determinant of inhibitory potency.(ABSTRACT TRUNCATED AT 250 WORDS)
<i>NTRK1</i> gene fusions as a novel oncogene target in lung cancer. (2013)

8023 Background: The identification and therapeutic targeting of oncogenic drivers in lung adenocarcinoma has led to significant clinical improvements for patients with EGFR mutations or ALK fusions. However, many lung cancer patients do not yet have an identified oncogenic driver and the discovery of new actionable oncogenic drivers is thus an active area of investigation. Methods: Tumor samples from 36 ‘pan-negative’ (EGFR, KRAS, ALK, and ROS1) lung adenocarcinoma patients were analyzed using a next generation sequencing (NGS) test performed in a CLIA-certified lab (Foundation Medicine, Cambridge, MA). Fluorescence in situ hybridization (FISH) screening using a novel NTRK1 break-apart assay was performed on an additional 61 pan-negative samples. Cells expressing the novel NTRK1 fusions were assayed for transformation and pharmacologic inhibition. Results: Two tumor samples were identified with gene fusions containing the kinase domain of TrkA, encoded by NTRK1, including one each with an MPRIP-NTRK1 (M21;N14) and CD74-NTRK1 (C8;N12) fusion. RT-PCR confirmed mRNA expression and identity of the fusion partner and FISH analysis detected split 5’/3’ signals corresponding to the NTRK1 gene. A third sample was identified by FISH analysis. Cloning and expression of MPRIP- and CD74-NTRK1 into NIH3T3 and Ba/F3 cells show constitutive activation of the TrkA kinase domain and transformation. Treatment of cells expressing NTRK1 fusions with several candidate pan-Trk inhibitors (ARRY-772, -523, and -470) as well as CEP-701 and crizotinib demonstrate decreased phosphorylation of the fusion oncoprotein and inhibition of cell proliferation. Treatment of the index patient harboring the MPRIP-NTRK1fusion with crizotinib led to minor transient tumor shrinkage. Conclusions: We identified a novel class of oncogenes, NTRK1 fusions, in lung adenocarcinomas that can be detected by NGS or FISH. Additional studies to determine the frequency and characteristics of NTRK1 fusions in lung cancer are ongoing. Our findings suggest prospective clinical trials of Trk inhibitors in NTRK1 fusion positive patients may be warranted. Support: CO Bioscience Discovery and Evaluation Grant and CO Clinical and Translational Sciences Institute Grant.
Nickel‐elicited systemic contact dermatitis (2003)

20 patients with systemic contact dermatitis due to nickel are described. Of these patients, 15 were female and 5 were male. Their mean age was 24.8 years (16-51 years). All had experienced contact dermatitis in the umbilical area due to continual contact with metal belt-buckles or buttons. Then, with long- or short-term aggravation of such periumbilical dermatitis, commonly in summer, lesions spread to other sites such as the side of the neck, the flexures of the extremities, etc. All patients showed a positive patch test to nickel sulphate (2.5% in petrolatum) and the dimethylglyoxime test demonstrated the presence of free nickel on metal buttons or belt-buckles. Punch biopsies performed in 7 patients showed subacute dermatitis. After avoidance of continual exposure to objects containing nickel and foods rich in nickel, as well as treatment with oral antihistamines and topical corticosteroids, all patients improved or cleared. It has been reported that nickel can cause systemic contact dermatitis by some internal systemic route, such as oral intake, transfusion, inhalation, implantation of metal medical devices, etc. In our patients, we found that continual local skin contact could also elicit systemic contact dermatitis.
Cocondensation reaction between phosphine and fluorine: matrix infrared spectra of difluorophosphorane, difluorophosphine and fluorophosphine (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCocondensation reaction between phosphine and fluorine: matrix infrared spectra of difluorophosphorane, difluorophosphine and fluorophosphineLester Andrews and Robert WithnallCite this: Inorg. Chem. 1989, 28, 3, 494–499Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://doi.org/10.1021/ic00302a023Request reuse permissionsArticle Views174Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (631 KB) Get e-Alertsclose Get e-Alerts
Preliminary studies on antiinflammatory and analgesic activities of Spilanthes acmella in experimental animal models (2004)

OBJECTIVE: To evaluate the antiinflammatory and analgesic activities of the aqueous extract of Spilanthes acmella (SPA) in experimental animal models. MATERIAL AND METHODS: SPA was evaluated for antiinflammatory action by carrageenan-induced rat paw edema. The analgesic activity was tested by acetic acid-induced writhing response in albino mice and tail flick method in albino rats. RESULTS: The aqueous extract of SPA in doses of 100, 200 and 400 mg/kg showed 52.6, 54.4 and 56.1% inhibition of paw edema respectively at the end of three hours and the percentage of protection from writhing was 46.9, 51.0 and 65.6 respectively. In the tail flick model, the aqueous extract of SPA in the above doses increased the pain threshold significantly after 30 min, 1, 2 and 4 h of administration. SPA showed dose-dependent action in all the experimental models. CONCLUSION: The present study indicates that SPA has significant antiinflammatory and analgesic properties.
A robust procedure for the functionalization of gold nanorods and noble metal nanoparticles (2009)

Towards a robust and universal functionalization procedure with alkanethiols for gold nanorods and plasmonic nanoparticles, a straightforward two-step approach is described.
Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes (2018)

Our results show that highly conserved M2e and HA2-2(76-130) can be used as important targets for the development of universal flu vaccines. The location of the HA2-2(76-130) peptide's insertion into the hypervariable domain of flagellin had a significant effect on the T-cell response to influenza antigens, as seen by forming of multi-cytokine-secreting CD4+ and CD8+ T-cells.
Three-dimensional propagation and scattering around a conical seamount (2009)

A three-dimensional (3D) propagation and scattering model is developed for an offset acoustic source in an ocean with axisymmetric bathymetry. Based on the same theoretical foundation as the formulation presented by Taroudakis [M. I. Taroudakis, "A coupled-mode formulation for the solution in the presence of a conical sea-mount," J. Comput. Acoust. 4, 101-121 (1996)], the present approach combines a spectral decomposition in azimuth with a coupled-mode theory for two-way, range-dependent propagation. However, the earlier formulations were severely limited in terms of frequency, size, and geometry of the seamount, the seabed composition, and the distance between the source and the seamount, and were therefore severely limited in regard to realistic seamount problems. Without changing the fundamental theoretical foundation, the present approach applies a number of modifications to the numerical formulation, leading to orders of magnitude in numerical efficiency for realistic problems. Further, by using a standard normal mode model for determining the fundamental modal solutions and coupling matrices, and by applying a simple superposition principle, the computational requirements are made independent of the distance between the seamount and the source and receivers, and dependent only on the geometry of the seamount and the source frequency. Therefore, realistic propagation and scattering scenarios can be modeled, including effects of seamount roughness and realistic sedimentary structure.
Reduction of CO2 emissions by mineral carbonation : steelmaking slags as rawmaterial with a pure calcium carbonate end product (2010)

Mineral carbonation is one of the options that can contribute to the reduction of carbon dioxide emissions for climate change mitigation purposes. Steel manufacturing, which is one of the biggest industrial sources of CO2 emissions, could benefit from this option by utilizing its own by-products, i.e., steelmaking slags, to combine with CO2. Additional benefits would be achieved if the end product was a pure and marketable calcium carbonate. The utilization of CaCO3 derived from steelmaking slag to replace some of the synthetic CaCO3 used in industry would simultaneously save virgin material resources, reduce carbon dioxide emissions, and provide a new utilization option for the low-value slag. \n The objective of the research reported in this thesis was to investigate the possibility of reducing CO2 emissions by utilizing steelmaking slags as raw material for CO2 mineralization. The target was that the end product of the CO2 mineralization would be a pure CaCO3 suitable for utilization. The suitability of the acetic acid process route suggested by Kakizawa et al. (2001) was tested first. Experiments showed that acetic acid dissolves calcium efficiently from steelmaking slags. A weak acetic acid solution was able to dissolve lime selectively from the steel converter slag, forming a clearly alkaline solution. Nonetheless, efficient CaCO3 precipitation required the addition of NaOH to prevent the regeneration of acid during carbonation, as well as to increase the alkalinity of the solution in those cases where a stronger acetic acid solution was used for the dissolution step. Preliminary process calculations revealed that chemical costs make the process clearly too expensive for CO2 sequestration. \n Because the production of pure CaCO3 from steelmaking slags with acetic acid was not feasible, various other solvents were tested. Three ammonium salt solutions (CH3COONH4, NH4NO3, and NH4Cl) dissolved calcium selectively from the steel converter slag and almost as efficiently as acids. The precipitated calcium carbonates were very pure. It was calculated that the production of pure calcium carbonate from steel converter slag by using ammonium salts as a solvent has clearly negative CO2 emissions. Since it was found that the method is not suitable for just any waste/by product materials that contain calcium, but should be applicable for at least those that contain free CaO, this method has potential only for minor-scale, yet significant, CO2 storage. A clear advantage is, however, that it uses a low value by-product as its raw material and has economic potential.
Research Update: Synthesis of sub-15-nm diameter silver nanowires through a water-based hydrothermal method: Fabrication of low-haze 2D conductive films (2017)

We synthesized ultra-thin Ag nanowire (Ag NWs) with sub-15 nm diameters and aspect ratios of 1000 through a water-based high-pressure hydrothermal method in the presence of a tetrabutylammonium dichlorobromide organic salt and glucose reducing agent. In the crystal growth stage, the diameter of the NWs could be controlled by adjusting the pressure, and 15-nm diameter wires were obtained at a pressure of 190 psi. These 2D conductive Ag NW network films showed an excellent optical performance with low haze value of ≤1.0% and 94.5% transmittance at a low sheet resistance of 20 Ω/sq.
A New High Performance Quaternary Phosphonium Biocide for Microbiological Control in Oilfield Water Systems (2008)

Abstract Microorganisms can cause severe problems in oilfield water systems. This paper describes a new quaternary phosphonium biocide based on tributyl tetradecyl phosphonium chloride (TTPC). Laboratory and field data has shown that TTPC is effective at low concentrations, is fast acting and is effective against both acid producing and sulfate reducing bacteria. It has out performed both glutaraldehyde and THPS in comparative biocidal tests giving complete kill of aerobic and anaerobic sulfate-reducing bacteria in one hour at 5 and 50 ppm active, respectively. Glutaraldehyde required &gt;40 and 150 ppm active and THPS required 40 and &gt;200 active to match the performance of TTPC versus aerobic and anaerobic sulfate-reducing bacteria, respectively. TTPC is compatible with oxidizing biocides, hydrogen sulfide and oxygen scavengers and has excellent thermal stability which makes it broadly applicable to oilfield water systems.
Modified Output Combining 3-Stage Doherty Power Amplifier Design for LTE Micro eNodeB (2015)

This paper presents a highly efficient modified output combining 3-stage Doherty Power Amplifier (DPA) design using low power LDMOS transistor for Band 40, TD-LTE Micro eNodeB. In this design, modified output combining technique has been used in the output section which meets the output power requirements of Micro eNodeB which cannot be achieved by conventional 3-stage DPA. The modified DPA design achieves 65.3% power added efficiency (PAE) at 39 dBm average output power with 20 MHz LTE signal using 15 watt LDMOS Transistor. 3-stage modified output combining technique increases the linear output power by 1.1 dB and increases the Gain flatness versus power level. The use of Digital Pre-Distortion (DPD) along with modified 3-stage DPA design achieves the linearity requirements as per the 3GPP specifications. The modified DPA combining technique has provided potential economical solution by using low power LDMOS transistor with an advantage of high efficiency.
Routing Protection Scheme For Redundancy In Fiber Communication Systems (1990)

Redundancy in communication systems is vital for providing customer satisfaction and a cost effective network. If a line is cut in present systems, the traffic on that line must be routed to other channels while an emergency repair is made. If the operating company cannot provide the bandwidth to satisfy this rerouting, it must rent information capacity from its competitors. Presently, fiber is being installed in the metropolitan and subscriber loop networks, and consideration is being taken to provide redundancy in network reconfiguration to reduce fiber breakage problems. In a full duplex communication network, individual optical waveguides are utilized for transmission and reception of signals. Figure 1 illustrates a typical metropolitan network link from office to office. If a cable is severed by accident during construction work, discontinuity of service would result. When there are thousands of premium-paying customers at the other end of that cable, this situation can achieve crisis level immediately. In this paper details of a route protection or diversification scheme will be presented that will incorporate an intelligent fiber optic system that will automatically detect a cable fault and switch traffic to redundant fiber cables.
Soluble P-Selectin and the Risk of Future Cardiovascular Events (2001)

Soluble P-selectin levels are elevated among apparently healthy women at risk for future vascular events.
EN MÉXICO, LAS REFORMAS EN EDUCACIÓN SUPERIOR FUERON IMPULSADAS POR EL EJECUTIVO FEDERAL (1997)

EN MEXICO, LAS TRANSFORMACIONES EN MATERIA DE EDUCACION SUPERIOR FUERON GENERALMENTE ACTIVADAS POR EL PODER EJECUTIVO FEDERAL, MEDIANTE DECRETOS, ACUERDOS Y NEGOCIACIONES SECTORIALES ESPECIFICOS. ASI LO SENALO EL DOCTOR ROLLING KENT, DEL CENTRO DE INVESTIGACIONES Y ESTUDIOS AVANZADOS (CINVESTAV) DEL IPN, AL PARTICIPAR EN EL TALLER SOBRE REFORMA DE LA EDUCACION SUPERIOR EN AMERICA LATINA. VINCULACIONES CON LA SOCIEDAD Y EL ESTADO, QUE SE EFECTUO EN EL CENTRO REGIONAL DE INVESTIGACIONES MULTIDISCIPLINARIAS (CRIM). EL PONENTE EXPLICO QUE ESTE ESQUEMA DE OPERACION RESPONDE A LO QUE SE CONOCE COMO LA PRIMERA GENERACION DE REFORMAS EN POLITICA ECONOMICA O SOCIAL. A DIFERENCIA DE MEXICO, INDICO, EN BRASIL EL PUNTO DE PARTIDA PARA DICHAS REFORMAS FUERON LAS ENMIENDAS CONSTITUCIONALES DE 1985. EN COLOMBIA SE REORGANIZO LA NORMATIVIDAD DEL SISTEMA UNIVERSITARIO A PRINCIPIOS DE LOS ANOS 90. EN AMBOS CASOS, DIJO, SE CONCIBIO LA REFORMA JURIDICA COMO EL PRIMER PASO DE LA REFORMA EDUCATIVA. EL DOCTOR KENT AFIRMO ASIMISMO QUE LA RELACION HISTORICA DE LAS INSTITUCIONES DE EDUCACION SUPERIOR Y LOS ESTADOS DE LA REGION LATINOAMERICANA ESTUVO MARCADO POR EL BINOMIO CONFLICTO-PARALISIS. POR UN LADO, LOS GOBIERNOS BUSCABAN CONTENER DENTRO DE LOS LIMITES MANEJABLES LA ACCION DE LOS UNIVERSITARIOS. POR OTRO, LAS UNIVERSIDADES SE MANTENIAN EN LA BUSQUEDA PERMANENTE DE APOYOS FINANCIEROS Y POLITICOS DE LOS GOBIERNOS QUE, SIN EMBARGO, NO CONDICIONARAN LA ACCION UNIVERSITARIA. EN ALGUNOS PAISES ESTA DIFICIL RELACION CONDUJO A UNA ESPECIE DE ACOMODAMIENTO EN EL QUE LAS UNIVERSIDADES Y OTRAS INSTITUCIONES PUBLICAS DE EDUCACION SUPERIOR NEGOCIABAN EL SUBSIDIO GUBERNAMENTAL CON LA PROMESA DE ENTREGAR A CAMBIO UN CICLO DE ESTABILIDAD. EXPLICO QUE ESTE VINCULO CON EL ESTADO, AUNADO AL ESQUEMA DE RELACIONES INTERNAS, SE RECONOCIO EN LOS ANOS 80 COMO INEFICAZ PARA LA REALIZACION DE REFORMAS PROPIAMENTE EDUCATIVAS Y COMO SUSCEPTIBLE DE CICLOS CRONICOS DE CONFLICTO E INESTABILIDAD. EN SUMA, DIJO, LLEGARON LAS UNIVERSIDADES A LOS ANOS 90 CON UN DEFICIT DE LEGITIMIDAD, OCASIONANDO LA EXTENSION VELOZ DEL SECTOR PRIVADO. ASEGURO QUE CHILE ES EL UNICO PAIS DE AMERICA LATINA QUE REALIZO CAMBIOS EN POLITICAS DE EDUCACION SUPERIOR EN LOS ANOS 90.
Simulation and modeling of the low-frequency base resistance of bipolar transistors and its dependence on current and geometry (1991)

The current and geometry dependence of the low-frequency base resistance of high-speed bipolar transistors was investigated by means of quasi-three-dimensional numerical device simulations. It is shown that the total base resistance can be separated into a current- and geometry-dependent internal part and an only geometry-dependent external part. Both of these parts can be accurately approximated by simple analytical formulas which are well suited for compact transistor modeling. The investigations are based on sheet resistances and dimensions the values of which are typical for self-aligned double-polysilicon technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>