gebhart/patrepeval huggingface dataset:
Fast Calculation of PM Eddy Current Loss in IPMSM Under PWM VSI Supply Based on the Spectra of Line-Line Voltage (2018)

A new method for fast calculating the permanent magnet (PM) eddy current losses (ECLs) in interior PM synchronous machine caused by the high-frequency harmonic voltages (HFHVs) under pulsewidth modulation (PWM) voltage source inverter supply is proposed, by which time-consuming transient finite element analysis (FEA) is eliminated and the influence of the axial segmentation on the PM ECLs can be taken into consideration. The combination of the fixed differential permeability method and the linear frequency FEA is proposed to investigate the relationship between arbitrary HFHV and the corresponding PM ECL at different load conditions. The analytical model proposed in the previous published paper is used to describe this relationship quantitatively. Finally, the total PM ECLs at different load conditions can be calculated based on the fast Fourier transform results of the input PWM voltages. The relative errors between the total losses obtained with the proposed method and those with time-stepping FEA are within 21% at four typical load conditions, and the proposed method can reduce the computation time for one load condition to few minutes considering arbitrary PM axial segmentation.
Electrification of turbocharger and supercharger for downsized internal combustion engines and hybrid electric vehicles-benefits and challenges (2016)

Forced induction technology (turbocharging and supercharging) can enhance the performance of an internal combustion engine by compressing inlet air charge, allowing full engine power to be produced efficiently. As the fuel economy and greenhouse gas emission standards are projected to be much more stringent globally, the use of a forced induction engine in passenger cars and light duty trucks has become a new inevitable trend in the automotive industry. However, the conventional forced induction system suffers from the slow transient response, especially when the engine speed is low, a phenomenon typically known as turbo lag. The electrification of forced induction system, called electric forced induction system (EFIS), has emerged as a feasible solution and it also possesses numerous benefits depending on its topologies. This paper provides a comprehensive study on EFIS by investigating system level topologies, performance, various types of high-speed machines, power electronics, and control techniques. The advantages and disadvantages of existing electric forced induction system are summarized and the new challenges and opportunities are also introduced.
Development of Campus Facility Management System using GIS - Focused on Kyungpook National University - (1998)

This paper, deals with the developmental result of university facility management system using GIS, is to explain the developmental process of this system and the merits and the faults of GIS facility management system. Facility management, as a discipline, is the practice of coordinating the people and the work of an organization into the physical workplace. According to rising costs for the facility management and effective management for the existing facility, the organization need to optimize the use of existing facilities and equipment to prevent unnecessary investments in facilities and equipment. The purpose of this study is to build GIS based university facility management system using GIS. Based on 1/5,000 from national geography institute and 1/600 map, we construct base map for study and, using genasys genius program, we made facility management system. This system includes geographic management, infrastructure management and building management, and, using each attribute information, it is possible to use not only for effective management for existing facilities but also available to future decision making.
Validating a dynamic signature monitoring approach using the LTL model checking technique (2004)

International audience
Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer (2020)

Significance In mouse models of triple-negative breast cancer, we show that the oxidation of tumor cells prior to lysate generation, coupled with their compartmentalization in the core of liposomal spherical nucleic acids (SNAs) comprised of adjuvant DNA, yields a powerful immunotherapeutic that significantly inhibits tumor growth, dramatically extends survival, and promotes a tumoricidal immune cell population within the tumor microenvironment. Specifically, this work points toward the importance of properly packaging and presenting the adjuvant and antigens such that biodistribution, dendritic cell activation, and therapeutic efficacy can be controlled.
Protecting Military Avionics Platforms from Attacks on MIL-STD-1553 Communication Bus (2017)

MIL-STD-1553 is a military standard that defines the physical and logical layers, and a command/response time division multiplexing of a communication bus used in military and aerospace avionic platforms for more than 40 years. As a legacy platform, MIL-STD-1553 was designed for high level of fault tolerance while less attention was taken with regard to security. Recent studies already addressed the impact of successful cyber attacks on aerospace vehicles that are implementing MIL-STD-1553. In this study we present a security analysis of MIL-STD-1553. In addition, we present a method for anomaly detection in MIL-STD-1553 communication bus and its performance in the presence of several attack scenarios implemented in a testbed, as well as results on real system data. Moreover, we propose a general approach towards an intrusion detection system (IDS) for a MIL-STD-1553 communication bus.
Guidance for the treatment of deep vein thrombosis and pulmonary embolism (2020)

This guidance document focuses on the diagnosis and treatment of venous thromboembolism (VTE). Efficient, cost effective diagnosis of VTE is facilitated by combining medical history and physical examination with pre-test probability models, D dimer testing and selective use of confirmatory imaging. Clinical prediction rules, biomarkers and imaging can be used to tailor therapy to disease severity. Anticoagulation options for acute VTE include unfractionated heparin, low molecular weight heparin, fondaparinux and the direct oral anticoagulants (DOACs). DOACs are as effective as conventional therapy with LMWH and vitamin K antagonists. Thrombolytic therapy is reserved for massive pulmonary embolism (PE) or extensive deep vein thrombosis (DVT). Inferior vena cava filters are reserved for patients with acute VTE and contraindications to anticoagulation. Retrievable filters are strongly preferred. The possibility of thoracic outlet syndrome and May-Thurner syndrome should be considered in patients with subclavian/axillary and left common iliac vein DVT, respectively in absence of identifiable triggers. The optimal duration of therapy is dictated by the presence of modifiable thrombotic risk factors. Long term anticoagulation should be considered in patients with unprovoked VTE as well as persistent prothrombotic risk factors such as cancer. Short-term therapy is sufficient for most patients with VTE associated with transient situational triggers such as major surgery. Biomarkers such as D dimer and risk assessment models such the Vienna risk prediction model offer the potential to customize VTE therapy for the individual patient. Insufficient data exist to support the integration of bleeding risk models into duration of therapy planning.
Chloro‐ and Alkyltitanium Complexes of a New Dianionic Ancillary Ligand: A Linked Amidinate−Amide (2003)

Abstract The lithium amidinate [Me 3 SiNC(Ph)N(CH 2 ) 3 N(Me)SiMe 3 ]Li(THF) ( 2 ), with a pendant methyl(trimethylsilyl)amine functionality, was prepared and found to react with [TiCl 4 (THF) 2 ] to give the titanium amidinate−amide dichloride complex [η 2 ,η 1 ‐Me 3 SiNC(Ph)N(CH 2 ) 3 NMe]TiCl 2 ( 3 ) by elimination of LiCl and Me 3 SiCl. The elimination of Me 3 SiCl from the cyclopentadienyl derivative Cp[η 2 ‐Me 3 SiNC(Ph)N(CH 2 ) 3 N(SiMe 3 )Me]TiCl 2 ( 5 ) to give Cp[η 2 ,η 1 ‐Me 3 SiNC(Ph)N(CH 2 ) 3 NMe]TiCl ( 4 ) is much less favorable, and was found to be readily reversible. Dialkyltitanium complexes [η 2 ,η 1 ‐Me 3 SiNC(Ph)N(CH 2 ) 3 NMe]Ti(CH 2 R) 2 [R = Ph ( 6 ), SiMe 3 ( 7 )] were prepared, but could not be activated for catalytic ethene polymerization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Enhancing<i>mda</i>-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery (2010)

We have determined whether an adenovirus that comprises the tail and shaft domains of a serotype 5 virus and the knob domain of a serotype 3 virus expressing MDA-7/IL-24, Ad.5/3-mda-7, more effectively infects and kills renal carcinoma cells (RCCs) compared to a serotype 5 virus, Ad.5-mda-7. RCCs are a tumor cell type that generally does not express the receptor for the type 5 adenovirus; the coxsackie and adenovirus receptor (CAR). Ad.5/3-mda-7 infected RCCs to a much greater degree than Ad.5-mda-7. MDA-7/IL-24 protein secreted from Ad.5/3-mda-7-infected RCCs induced MDA-7/IL-24 expression and promoted apoptosis in uninfected "bystander" RCCs. MDA-7/IL-24 killed both infected and bystander RCCs via CD95 activation. Knockdown of intracellular MDA-7/IL-24 in uninfected RCCs blocked the lethal effects of conditioned media. Infection of RCC tumors in one flank, with Ad.5/3-mda-7, suppressed growth of infected tumors and reduced the growth rate of uninfected tumors implanted on the opposite flank. The toxicity of the serotype 5/3 recombinant adenovirus to express MDA-7/IL-24 was enhanced by combined molecular or small molecule inhibition of MEK1/2 and PI3K; inhibition of mTOR, PI3K and MEK1/2; or use of the multi-kinase inhibitor sorafenib. In RCCs, combined inhibition of cytoprotective cell signaling pathways enhanced the MDA-7/IL-24-induction of CD95 activation, with greater mitochondrial dysfunction due to loss of MCL-1 and BCL-XL expression, and tumor cell death. Treatment of RCC tumors in vivo with sorafenib also enhanced Ad.5/3-mda-7 toxicity and prolonged animal survival. Future combinations of these approaches hold promise for developing a more effective therapy for kidney cancer.
Use of <i>tuf</i> Sequences for Genus-Specific PCR Detection and Phylogenetic Analysis of 28 Streptococcal Species (2004)

A 761-bp portion of the tuf gene (encoding the elongation factor Tu) from 28 clinically relevant streptococcal species was obtained by sequencing amplicons generated using broad-range PCR primers. These tuf sequences were used to select Streptococcus-specific PCR primers and to perform phylogenetic analysis. The specificity of the PCR assay was verified using 102 different bacterial species, including the 28 streptococcal species. Genomic DNA purified from all streptococcal species was efficiently detected, whereas there was no amplification with DNA from 72 of the 74 nonstreptococcal bacterial species tested. There was cross-amplification with DNAs from Enterococcus durans and Lactococcus lactis. However, the 15 to 31% nucleotide sequence divergence in the 761-bp tuf portion of these two species compared to any streptococcal tuf sequence provides ample sequence divergence to allow the development of internal probes specific to streptococci. The Streptococcus-specific assay was highly sensitive for all 28 streptococcal species tested (i.e., detection limit of 1 to 10 genome copies per PCR). The tuf sequence data was also used to perform extensive phylogenetic analysis, which was generally in agreement with phylogeny determined on the basis of 16S rRNA gene data. However, the tuf gene provided a better discrimination at the streptococcal species level that should be particularly useful for the identification of very closely related species. In conclusion, tuf appears more suitable than the 16S ribosomal RNA gene for the development of diagnostic assays for the detection and identification of streptococcal species because of its higher level of species-specific genetic divergence.
A simple electrostatic criterion for predicting the thermal stability of proteins (2003)

The enhancement of protein thermostability is an important issue for both basic science and biotechnology purposes. We have developed a thermostability criterion for a protein in terms of a quasi-electric dipole moment (contributed by its charged residues) defined for an electric charge distribution whose total charge is not zero. It was found that minimization of the modulus of this dipole moment increased its thermal stability, as demonstrated by surveying these values in pairs of mesostable-thermostable homologous proteins and in mutations described in the literature. The analysis of these observations provides criteria for thermostabilization of a protein, by computing its dipole profile. This profile is obtained by direct substitution of each amino acid of the sequence by either a positive, negative or neutral amino acid, followed by a recalculation of the dipole moment. As an experimental example, these criteria were applied to a beta-glucanase to enhance its thermal stability.
Study on the Permanent Magnet Demagnetization Fault in Permanent Magnet Synchronous Machines (2006)

This article studies the permanent magnet demagnetization fault in permanent magnet synchronous machines (PMSM). The study is carried out by analyzing the harmonics obtained using the fast Fourier transform (FFT) of stator and zero sequence currents at nominal torque for the whole range of machine operation speeds. The appropriate combination of analyses on the different currents makes it possible to determine the faults for any speed range
LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia (2020)

The LMO2/LDB1 macromolecular complex is critical in hematopoietic stem and progenitor cell specification and in the development of acute leukemia. This complex is comprised of core subunits of LMO2 and LDB1 as well as <u>s</u>ingle-<u>s</u>tranded DNA-<u>b</u>inding <u>p</u>rotein (SSBP) cofactors and DNA-binding <u>b</u>asic <u>h</u>elix-<u>l</u>oop-<u>h</u>elix (bHLH) and GATA transcription factors. We analyzed the steady-state abundance and kinetic stability of LMO2 and its partners via Halo protein tagging in conjunction with variant proteins deficient in binding their respective direct protein partners. We discovered a hierarchy of protein stabilities (with half-lives in descending order) as follows: LDB1 > SSBP > LMO2 > TAL1. Importantly, LDB1 is a remarkably stable protein that confers enhanced stability upon direct and indirect partners, thereby nucleating the formation of the multisubunit protein complex. The data imply that free subunits are more rapidly degraded than those incorporated within the LMO2/LDB1 complex. Our studies provided significant insights into LMO2/LDB1 macromolecular protein complex assembly and stability, which has implications for understanding its role in blood cell formation and for therapeutically targeting this complex in human leukemias.
Identification of the promoter region involved in the autoregulation of the transcriptional activator ALCR in Aspergillus nidulans. (1992)

The ALCR protein is the transcriptional activator of the ethanol utilization pathway in the filamentous fungus Aspergillus nidulans. This activator belongs to a family of fungal proteins having a conserved DNA-binding domain containing six cysteines (C6 class) with some striking features. At variance with other motifs of this class, the binding domain of ALCR is strongly asymmetrical in relation to the central cysteines and moreover was predicted to adopt a helix-turn-helix structure. This domain of ALCR was synthesized in Escherichia coli and purified as a glutathione-S-transferase fusion protein. Our results show that the transcriptional activator ALCR is a DNA-binding protein. The DNA-binding motif contains zinc that is necessary for the specific DNA binding. The ALCR peptide binds upstream of the coding region of alcR to two specific targets with different affinities that are characterized by a conserved 5-nucleotide core, 5'-CCGCA-3' (or its reverse). One site, the lower-affinity binding site, is a direct repeat, and the other, the higher-affinity binding site, is a palindromic sequence with dyad symmetry. Therefore, the ALCR binding protein is able to recognize one DNA sequence in two different configurations. An alcR mutant obtained by deletion of the two specific targets in the cis-acting region of the alcR gene is unable to grow on ethanol and does not express any alcohol dehydrogenase activity. These results demonstrate that the binding sites are in vivo functional targets (UASalc) for the ALCR protein in A. nidulans. They corroborate prior evidence that alcR is autoregulated.
Subcorneal colocalization of the small heat shock protein, hsp27, with keratins and proteins of the cornified cell envelope (2002)

These results provide morphological evidence that in normal human skin hsp27 might act as a chaperone of cornification. Investigations of the molecular hsp27 interactions with the proteins of the cornified cell envelope are necessary to gain further insight into terminal keratinocyte differentiation and disorders of keratinization.
A graphical programming language for robots operating in lightly structured environments (2002)

An environment for programming robot manipulations using graphical symbols (RoboGlyph) is presented. Programs are assembled by dragging a sequence of symbols representing robot positions and motions onto a storyboard that stores the sequence of motions needed to perform a task. The RoboGlyph system is being used to program a service robot for severely disabled (high-level quadriplegic) users. It is expected that it will significantly ease the task of creating, maintaining and documenting programs for the robot.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
T cell lines active in the delayed-type hypersensitivity reaction (DTH). (1981)

Two allospecific uncloned T cell lines, C.C3.11.75 (H-2d anti-H-2k) and B6-C.7.76 (H-2b anti-H-2d), were assayed for their ability to elicit a DTH reaction in vivo. It was shown that both cell lines, C.C3.11.75 being cytolytic and B6-C.7.76 being noncytolytic, evoke a strong DTH reaction. The reaction was in tempo and histology typical for a DTH reaction and could not be distinguished from a DTH reaction elicited by in vivo generated T cells active in a GVH reaction. Both cell lines recognize a private specificity encoded in the H-2 IA subregion. Cell proliferation of the responder cells did not appear to be critical in the reaction nor are T cells from the host recruited during the reaction. The DTH reaction can be assayed in allogeneic hosts demonstrating a complete lack of H-2 restriction in the reaction even when presumably antigen presenting macrophages are removed from the stimulator cell population. Furthermore, tumor cells expressing IA antigens could be employed to cause the reaction in both syngeneic and allogeneic recipients. Cloned sublines of one of the lines are also active in the reaction.
Widening Access to Applied Machine Learning with TinyML (2022)

Broadening access to both computational and educational resources is critical to diffusing machine learning (ML) innovation. However, today, most ML resources and experts are siloed in a few countries and organizations. In this article, we describe our pedagogical approach to increasing access to applied ML through a massive open online course (MOOC) on Tiny Machine Learning (TinyML). We suggest that TinyML, applied ML on resource-constrained embedded devices, is an attractive means to widen access because TinyML leverages low-cost and globally accessible hardware and encourages the development of complete, self-contained applications, from data collection to deployment. To this end, a collaboration between academia and industry produced a four part MOOC that provides application-oriented instruction on how to develop solutions using TinyML. The series is openly available on the edX MOOC platform, has no prerequisites beyond basic programming, and is designed for global learners from a variety of backgrounds. It introduces real-world applications, ML algorithms, data-set engineering, and the ethical considerations of these technologies through hands-on programming and deployment of TinyML applications in both the cloud and on their own microcontrollers. To facilitate continued learning, community building, and collaboration beyond the courses, we launched a standalone website, a forum, a chat, and an optional course-project competition. We also open-sourced the course materials, hoping they will inspire the next generation of ML practitioners and educators and further broaden access to cutting-edge ML technologies.
Stresses and Magnetic Domain Structure of Amorphous Alloys (1987)

In recent papers the relation between stresses and magnetic domain structure is still analyzed based on a simplified assumption, that the magnetoelastic anisotropy energy density will be a minimum with respect to the orientation of the magnetization. In the present paper the relation between stresses and domain structure is exactly treated on the basis of the micromagnetic equations using the stability condition following from the condition that the Gibbs free energy of the ferromagnetic specimen as a whole must be a minimum. In der Literatur wird die Beziehung zwischen Spannungen und magnetischer Domänenstruktur generell auf der Grundlage einer vereinfachten Annahme, daß die magnetoelastische Energiedichte bezüglich der Orientierung der Magnetisierung ein Minimum annimmt, analysiert. In der vorliegenden Arbeit wird die Beziehung zwischen Spannungen und Domänenstruktur exakt auf der Grundlage der mikromagnetischen Gleichungen behandelt, wobei die aus der Forderung folgende Stabilitätsbedingung, daß die freie Enthalpie des gesamten Ferromagneten ein Minimum sein muß, verwendet wird.
Fluxionality of iron complex Fe2(CO)4(.eta.-C5H5)2 revisited (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluxionality of iron complex Fe2(CO)4(.eta.-C5H5)2 revisitedLouis J. Farrugia and Lesley MustooCite this: Organometallics 1992, 11, 8, 2941–2944Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/om00044a041https://doi.org/10.1021/om00044a041research-articleACS PublicationsRequest reuse permissionsArticle Views297Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts