gebhart/patrepeval huggingface dataset:
Efficacy of hydrated sodium calcium aluminosilicate in reducing the toxicity of dietary zearalenone to mink (1992)

Ovariectomized mink were fed diets containing zearalenone (ZEN) at concentrations of 0, 10 or 20 ppm with or without 0.5% hydrated sodium calcium aluminosilicate (HSCAS) for 24 days. Zearalenone at 10 and 20 ppm caused a significant increase in uterine weights, while 20 ppm ZEN resulted in significantly higher vulva swelling scores when compared to controls. The presence of HSCAS in the diet did not alter these hyperestrogenic effects of ZEN. In a second experiment, female mink were provided diets containing 20 ppm ZEN, 20 ppm ZEN plus 0.5% HSCAS or a control diet from 1 January 1989 through whelping (25 April to 15 May 1989). The females were given an opportunity to mate with untreated proven breeder males beginning on 1 March (day 59 of exposure). ZEN did not have an effect on the number of females whelping but there was a significant increase in gestation length, a decrease in litter size and an increase in kit mortality from birth to 3 weeks of age when compared to the control group and the group receiving the combination of ZEN and HSCAS. These results suggest that HSCAS can alleviate some of the reproductive effects of ZEN which are not related to its estrogenic action.
Requirement for Arf6 in breast cancer invasive activities (2004)

In most human breast cancer cell lines, there is a direct correlation between their in vivo invasive phenotypes and in vitro invasion activities. Here, we found that ADP-ribosylation factor 6 (Arf6) is localized at the invadopodia of the cultured breast cancer cells MDA-MB-231, and its suppression by a small-interfering RNA duplex effectively blocks the invasive activities of the cells, such as invadopodia formation, localized matrix degradation and Matrigel transmigration but not the cell-adhesion activity. We also found that the GTP hydrolysis-defective mutant Arf6(Q67L) and the GTP-binding defective mutant Arf6(T27N) both blocked these invasive activities but not cell adhesion, suggesting the necessity of continued activation and cycling of the Arf6 GTPase cycle in invasion. Among the different human breast cancer cell lines that we examined, cell lines with high invasive activities expressed higher amounts of Arf6 protein than those in weakly invasive and noninvasive cell lines, although no notable correlation was found between Arf6 mRNA expression levels and invasive activities. Moreover, Matrigel-transmigration activity of all of these invasive cells was blocked effectively by an Arf6 small-interfering RNA duplex. Hence, Arf6 appears to be an integral component of breast cancer invasive activities, and we propose that Arf6 and the intracellular machinery regulating Arf6 during invasion should be considered as therapeutic targets for the prevention of breast cancer invasion.
[Methodological aspects of the optimal use of combined chemo- and immunotherapy]. (1990)

Methodical aspects of developing rational schemes of combined use of antibiotics and immunomodulators are discussed. Chemotherapeutic drugs are synergists of the factors of nonspecific resistance i. e. enzymes, cationic proteins, etc. However, prediction of the effect of both etiotropic agents and immunomodulators on resistance and immunity is rather complicated. A system for estimating efficacy of combined chemo- and immunotherapy based on multifactorial analysis is described. The main steps of the system are the following: choice of the quality criteria, determination of the experimental factors and levels, choice of the experimental design, performance of the experiment, computer processing of the results, construction of a polynomial statistic model and solution of the therapy problems. The method is universal and applicable to any combination of chemotherapeutics and immunomodulators.
Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells (2004)

Edelfosine (ET-18-OCH3), a synthetic antitumor ether lipid, is taken up by malignant but not by normal cells, triggering apoptosis in a large variety of human tumor cells. The synthesis of the first fluorescent edelfosine analogue (6), with apoptotic activity comparable to that of the parent drug, is described. Fluorescence microscopy experiments show that 6 selectively labels human cancer cells, accumulating into specific domains of the plasma membrane.
OFDM with guard interval and sub-channel equalization in a 2-resolution transmission scheme for digital television broadcasting (2002)

The interest in a new digital terrestrial TV system, that allows improved quality and receiver portability, leads to the choice of a modulation system suitable for operation in a very hostile environment (interferences, multipath). A very effective solution, already experimented with digital audio broadcasting, is the orthogonal frequency division multiplexing (OFDM) technique with a guard interval. Unluckily such an interval grows from a few ten microseconds, sufficient for typical urban propagation environment, up to 600 microseconds, when the emerging single frequency network (SFN) is considered. A long guard interval (as required in a SFN) results in a excessive prolongation of the symbol period (T) and thus in bandwidth efficiency loss. In addition, the use of a too long symbol period is limited by the effects of time selectivity of the channel and by technological limitations. In this light, the use is suggested of a shorter guard interval and a low complexity equaliser at the output of each subcarrier to reduce the error produced by the echoes exceeding the guard interval duration. A multiresolution (MR) transmission scheme has been adopted in order to eliminate the sharp threshold effect in the fringes of the broadcast area. The system performances of a 2-resolution OFDM system have been evaluated by computer simulation on a frequency-selective channel for Rice and Rayleigh propagation environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Altered Autonomic Support of Arterial Blood Pressure With Age in Healthy Men (2001)

ANS support of BP is altered with age in healthy men due to less cardiac vagal inhibition of heart rate and cardiac output. Basal sympathetic activity and alpha-adrenergic vascular sensitivity are also key physiological correlates of ANS support of BP in healthy men.
Measurement of Blood Loss during Adenotonsillectomy in Children and Factors Affecting It (2015)

This prospective study was done at the Southern Railway Headquarters Hospital, Ayanavaram, Chennai to measure the intraoperative blood loss during adenotonsillectomy and to assess the factors affecting it. Since blood volume in children is low, even a small loss will result in dreaded complications, so blood loss measurement in paediatric surgery is important. Adenotonsillectomy is the most common surgery performed in the field of otolaryngology, so blood loss measurement is essential in this surgery. In the study, 50 children who underwent adenotonsillectomy, by conventional dissection and snare method for tonsillectomy and curette method for adenoidectomy, were evaluated for operative blood loss. This study was conducted over a 1 year period, from June 2013 to June 2014. Both gravimetric method and blood volume studies were used to measure the operative blood loss. The estimated blood loss by gravimetric method was 94.35 ml, whereas the actual blood loss by blood volume studies was 90.57 ml and the average blood loss was 92.46 ml. The youngest child who was operated was 4 years old and the oldest child was 15 years old. The minimum blood loss was 40.30 ml and the maximum was 278.46 ml. In our series, operative blood loss was dependent on fibrosis of tonsil and the grade of the tonsil. There was no significant correlation between age and sex of the patient and the surgical skills.
Identification of <i>P1</i> Variants of <i>Mycoplasma pneumoniae</i> by Use of High-Resolution Melt Analysis (2009)

Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia. Although two genetically distinct types of M. pneumoniae are known, variants of each also exist. We used a real-time PCR high-resolution melt genotyping assay to identify clinical variants which may provide greater insight into the genetic distribution of M. pneumoniae strains.
4‐(Arylaminothiocarbonyl)‐1‐(1‐<i>o</i>‐methoxyphenylcarbamido)‐ethylpiperazines as anticonvulsants (1980)

Abstract Several 4‐(arylaminothiocarbonyl)‐1‐(1‐ o ‐methoxyphenylcarbamido)‐ethylpiperazines were synthesized and evaluated for their anticonvulsant activity against pentylenetetrazol‐induced seizures in mice. The ability of substituted piperazines to inhibit in vitro respiratory activity of rat brain homogenates was also determined to study their structure‐activity relationship.
MILES; a laser training aid (1982)

The multiple integrated laser engagement system (MILES) has now reached technological maturity and is currently being deployed at over 20 U.S. Army- bases in the United States, Europe, and Korea. Using GaAs lasers, silicon detectors, and microprocessor logic, MILES has revolutionized tactical infantry and armor training by providing a degree of realism not previously available. This paper will discuss some of the essential physics of MILES, including laser/detector beam geometry, atmospheric scintillation effect, code theory, and eye safety constraints.
Spray and trap method for water analysis by thermal desorption gas chromatography/mass spectrometry in field applications (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpray and trap method for water analysis by thermal desorption gas chromatography/mass spectrometry in field applicationsGerhard. Matz and Peter. KesnersCite this: Anal. Chem. 1993, 65, 17, 2366–2371Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ac00065a033https://doi.org/10.1021/ac00065a033research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Exploring frontiers of orbitrap performance for long transients (2021)

Experiments on a modified Orbitrap Exploris instrument have shown that even in a compact instrument it is possible to achieve a resolving power in excess of 2,000,000 when appropriate tolerance and tuning requirements are met. Such levels are achieved for a 4-s detection time. A new Orbitrap design with improved pumping allowed, for the first time, isotopic resolution of intact monoclonal antibodies even when using standard nitrogen supply in the Ion Routing Multipole. Longer transients further improve signal-to-noise ratios, approaching levels needed for single-charge resolution in charge detection mass spectrometry. Further steps for improvement of instrumentation are discussed.
Morphologic alterations in esophageal squamous cell carcinoma after preoperative high dose rate intraluminal brachytherapy (1996)

HDRILBT may cause the keratin gene in the irradiated cells to induce differentiation toward better differentiated cells. Preoperative high dose rate intraluminal brachytherapy may have a role in improving the prognosis of patients with early esophageal cancer treated with a combination of radiotherapy and surgery.
Development of a general purpose low-power small-area 10 bit current steering CMOS DAC (2009)

The design and measurements of the prototype general purpose digital to analog converter for readout systems in high energy physics experiments are presented. The main goals for the proposed DAC are low power consumptions, small die area and high output swing. The 10 bit DAC design is based on current steering architecture comprising high swing class AB output amplifier. The prototype ASIC is fabricated in the 2P–4M 0.35-µm technology. The measurements of maximum differential (DNL) and integral (INL) nonlinearity show 0.8 and 0.6 LSB respectively. The total power consumption is below 0.6 mW while the area is 0.18 mm2.
A randomised trial to assess the safety and efficacy of artemether–lumefantrine (Coartem®) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwanda (2006)

Coartem is a fixed-dose combination of artemether-lumefantrine that, given in six doses, provides effective treatment for children with uncomplicated Plasmodium falciparum infection in areas with highly endemic and multidrug-resistant malaria. In Rwanda since 2001, amodiaquine+sulfadoxine-pyrimethamine (AQ+SP) has been the first-line treatment, but resistance to this combination has rapidly emerged and spread. Coartem was considered as a possible alternative, and a randomised, open-label, clinical trial to test its safety, tolerability and efficacy was carried out in 2004-2005. Five hundred children aged 12-59 months with uncomplicated P. falciparum malaria were randomly allocated to AQ+SP or Coartem. Patients were followed up until day 28 after treatment. Adverse events and clinical and parasitological outcomes were recorded. Adequate clinical and parasitological response (ACPR) was significantly higher in children treated with Coartem than in those treated with AQ+SP: the PCR-adjusted 28-day ACPR was 96.68% for Coartem and 79.35% for AQ+SP. Both treatments rapidly cleared parasitaemia and fever, although parasite clearance was significantly faster in children treated with Coartem. Mean packed cell volume increased in all patients, with no significant differences between treatments. Coartem proved to be more efficacious than AQ+SP, with a good safety and tolerability profile.
New insights into Escherichia coli metabolism: carbon scavenging, acetate metabolism and carbon recycling responses during growth on glycerol (2012)

The overexpression of several carbon scavenging, acetate metabolism genes and the absence of acetate accumulation occurred in JM101 cultures growing on glycerol. To explain these results it is proposed that in addition to the glycolytic metabolism, a gluconeogenic carbon recycling process that involves acetate is occurring simultaneously in this strain when growing on glycerol. Carbon flux from glycerol can be efficiently redirected in JM101 strain into the aromatic pathway using appropriate tools.
Earlier immunomodulatory treatment is associated with better visual outcomes in a subset of patients with <scp>V</scp>ogt‐<scp>K</scp>oyanagi‐<scp>H</scp>arada disease (2015)

There were no differences in outcomes between first-line IMT and prednisone alone/late IMT in the entire VKH group. However, in a subset of patients, there was a significant better functional outcome with earlier IMT initiation.
Expression of bar gene driven by 5′-flanking regions of nitrate reductase from Dunaliella salina (2008)

Aim: To study the role of 5′-flanking region(Pnr) of nitrate reductase(NR) from Dunaliella salina(D.salina) in driving the expression of the heterologous genes.Methods:After an intermediate plasmid pGEM-7zf-Tnr was constructed by ligating Tnr(3′-flanking region of NR of D.salina) into the pEGM-7zf,a fusion gene Pnr-bar produced by gene splicing and overlap extension(SOEing) was inserted into the intermediate plasmid pGEM-7zf-Tnr to create a eukaryotic expression plasmid p7NBT harboring an expression cassette Pnr-bar-Tnr.Subsequently,the plasmid p7NBT was transformed into cells of D.salina and the transformed cells were screened with UTEX liquid medium containing 3 mg/L PPT.RT-PCR was performed to determine the transcription of the bar gene in D.salina.Results: Sequence of the bar gene was amplified in D.salina cells transformed with plasmid p7NBT,but not in cells of control group.Conclusion: Pnr from D.salina could drive the transcription of the bar gene.
Organizing an Undergraduate Gemology Course (1986)

Gemology can serve as an interesting and useful course for both geology and non-geology undergraduate majors. Such a course need not be expensive to offer, and can be taught on an interdisciplinary basis, including aspects of mineralogy, art, history, economics, and marketing. The equipment required includes gem microscopes, refractometers, polariscopes, dichroscopes, specific-gravity liquids, light sources, and hand lenses. A minimal set of equipment for ten students might cost about $1200. The cost of gem materials can be held down by purchasing low-cost specimens, working with local lapidaries and jewelers, and finding dealers who will sell to schools at a discount.
Silica to Silicon: Key Carbothermic Reactions and Kinetics (1990)

The primary carbothermic reactions for the reduction of silica to produce silicon were defined and the reaction kinetics were determined. Most possible reactions between silicon oxide and carbon or carbon compounds were studied by a series of thermogravimetric analyses at temperatures up to 2000°C. Four key sequential reactions occur with SiC and SiO as intermediate reactants; two reactions involve SiO 2 and two involve SiO. Reaction rate versus temperature, activation energy, and preexponential factors were determined for each of six reactions involving SiO 2 or SiO. These kinetic studies show that SiO, when combined with either carbon or Sic, reacts in the gaseous state, and the sublimation of SiO is not the rate‐limiting reaction for forming silicon.
Effects of Individualized and Standardized Interventions on Middle School Students with Reading Disabilities (2011)

This study reports the effectiveness of a year-long, small-group, tertiary (Tier 3) intervention that examined 2 empirically derived but conceptually different treatments and a comparison condition. The researchers had randomly assigned all students to treatment or comparison conditions. The participants were seventh- and eighth-grade students from the previous year who received an intervention and did not meet exit criteria. The researchers assigned them to one of two treatments: standardized (n = 69) or individualized (n = 71) for 50 min a day, in group sizes of 5, for the entire school year. Comparison students received no researcher-provided intervention (n = 42). The researchers used multigroup modeling with nested comparisons to evaluate the statistical significance of Time 3 estimates. Students in both treatments outperformed the comparison students on assessments of decoding, fluency, and comprehension. Intervention type did not moderate the pattern of effects, although students in the standardized treatment had a small advantage over individualized students on word attack. This study provides a framework from which to refine further interventions for older students with reading disabilities.
Cytoplasmic γ-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers (2011)

The sarcoplasmic reticulum (SR) serves as the Ca(2+) reservoir for muscle contraction. Tropomodulins (Tmods) cap filamentous actin (F-actin) pointed ends, bind tropomyosins (Tms), and regulate F-actin organization. In this paper, we use a genetic targeting approach to examine the effect of Tmod1 deletion on the organization of cytoplasmic γ-actin (γ(cyto)-actin) in the SR of skeletal muscle. In wild-type muscle fibers, γ(cyto)-actin and Tmod3 defined an SR microdomain that was distinct from another Z line-flanking SR microdomain containing Tmod1 and Tmod4. The γ(cyto)-actin/Tmod3 microdomain contained an M line complex composed of small ankyrin 1.5 (sAnk1.5), γ(cyto)-actin, Tmod3, Tm4, and Tm5NM1. Tmod1 deletion caused Tmod3 to leave its SR compartment, leading to mislocalization and destabilization of the Tmod3-γ(cyto)-actin-sAnk1.5 complex. This was accompanied by SR morphological defects, impaired Ca(2+) release, and an age-dependent increase in sarcomere misalignment. Thus, Tmod3 regulates SR-associated γ(cyto)-actin architecture, mechanically stabilizes the SR via a novel cytoskeletal linkage to sAnk1.5, and maintains the alignment of adjacent myofibrils.
Spreading dynamics of drop impacts (2012)

Abstract We present an experimental study of drop impact on a solid surface in the spreading regime with no splashing. Using the space–time-resolved Fourier transform profilometry technique, we can follow the evolution of the drop shape during the impact. We show that a self-similar dynamical regime drives the drop spreading until the growth of a viscous boundary layer from the substrate selects a residual minimal film thickness. Finally, we discuss the interplay between capillary and viscous effects in the spreading dynamics, which suggests a pertinent impact parameter.
Evaluation of the antiviral activity of orlistat (tetrahydrolipstatin) against dengue virus, Japanese encephalitis virus, Zika virus and chikungunya virus (2020)

Many mosquito transmitted viruses of the genera Alphavirus and Flavivirus are human pathogens of significant concern, and there is currently no specific antiviral for any member of these two genera. This study sought to investigate the broad utility of orlistat (tetrahydrolipstatin) in reducing virus infection for several mosquito borne viruses including flaviviruses (dengue virus (DENV; nine isolates analyzed), Japanese encephalitis virus (JEV; one isolate analyzed) and Zika virus (ZIKV; 2 isolates analyzed)) as well as an alphavirus (chikungunya virus; CHIKV; 2 isolates analyzed). Three different treatment regimens were evaluated, namely pre-treatment (only), post-treatment (only) and pre- and post-treatment, and three factors were evaluated, namely level of infection, virus titer and genome copy number. Results showed that all three treatment modalities were able to significantly reduce virus titer for all viruses investigated, with the exception of three isolates of DENV in the pre-treatment only regimen. Pre- and post-treatment was more effective in reducing the level of infection and genome copy number of all viruses investigated than either pre-treatment or post-treatment alone. Collectively, these results suggest orlistat has potential as a broad-spectrum agent against multiple mosquito transmitted viruses.