gebhart/patrepeval huggingface dataset:
3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D<sub>4</sub> Receptor (1996)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 ReceptorJanusz J. Kulagowski, Howard B. Broughton, Neil R. Curtis, Ian M. Mawer, Mark P. Ridgill, Raymond Baker, Frances Emms, Stephen B. Freedman, Rosemarie Marwood, Shil Patel, Smita Patel, C. Ian Ragan, and Paul D. LeesonView Author Information Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K. Cite this: J. Med. Chem. 1996, 39, 10, 1941–1942Publication Date (Web):May 10, 1996Publication History Received22 January 1996Published online10 May 1996Published inissue 1 January 1996https://doi.org/10.1021/jm9600712Copyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1285Altmetric-Citations204LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (105 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amines,Antagonists,Indoles,Receptors,Selectivity Get e-Alerts
Evolutionary design of electronic devices and circuits (2003)

The paper addresses the use of evolutionary algorithms in the design of electronic devices and circuits. In particular, the paper introduces the idea of evolutionary design of nanodevices, and illustrates it with the design of a resonant tunneling diode. A second experiment, this time using CMOS microdevices, illustrates the use of evolutionary algorithms for circuit design. The experiments were facilitated by an evolutionary design tool developed around a parallel implementation of genetic algorithms (using PGAPack), and device/circuit simulators (NEMO and SPICE). It is speculated that in the future, devices and circuits may be simultaneously co-designed.
Poly(aryl ether ketone) block and chain-extended copolymers. 1. Preparation and characterization of a new class of functional poly(aryl ether ketone) oligomers (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(aryl ether ketone) block and chain-extended copolymers. 1. Preparation and characterization of a new class of functional poly(aryl ether ketone) oligomersR. A. Clendinning, D. R. Kelsey, J. H. Botkin, P. A. Winslow, M. Youssefi, R. J. Cotter, M. Matzner, and G. T. KwiatkowskiCite this: Macromolecules 1993, 26, 9, 2361–2365Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://doi.org/10.1021/ma00061a031RIGHTS & PERMISSIONSArticle Views232Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (578 KB) Get e-Alerts Get e-Alerts
Data for Compact micro-optic based components for hollow core fibers (2019)

Data for the paper Jung, Yongmin ; Kim, Hyuntai ; Chen, Yong ; Bradley, Thomas ; Davidson, Ian ; Hayes, John ; Jasion, Gregory ; Sakr, Hesham ; Rikimi, Shuichiro ; Poletti, Francesco ; Richardson, David, 'Compact micro-optic based components for hollow core fibers', accepted for publication in Optics Express, November 2019
Control of the Bacterial Wilt of Tomato Plants by a Derivative of 3-Indolepropionic Acid Based on Selective Actions on <i>Ralstonia solanacearum</i> (1998)

3-Indolepropionic acid (IPA)-related compounds having a benzo[b]thiophene or an indazole ring and derivatives having various substituents in the propionic acid moieties were tested for their antibacterial activity against Ralstonia solanacearum. Substitution of the indole ring for other aromatic rings resulted in lowered activity, whereas addition of a methyl or a trifluoromethyl group to the propionic acid moiety had little effect. Of the derivatives, 3-(3-indolyl)butanoic acid (3-IBA) was as active as IPA, exhibiting a 10-fold higher activity with the S configuration than with the R configuration. In contrast with the strong phytotoxicity of IPA, 3-IBA was able to suppress bacterial wilt without affecting the growth of tomato plants. Keywords: 3-Indolepropionic acid; 3-(3-indolyl)butanoic acid; Ralstonia solanacearum; bacterial wilt; tomato plants
Increasing the imaging capabilities of multimode fibers by exploiting the properties of highly scattering media (2013)

We present a design that exploits the focusing properties of scattering media to increase the resolution and the working distance of multimode fiber (MMF)-based imaging devices. Placing a highly scattering medium in front of the distal tip of the MMF enables the formation of smaller sized foci at increased working distances away from the fiber tip. We perform a parametric study of the effect of the working distance and the separation between the fiber and the scattering medium on the focus size. We experimentally demonstrate submicrometer focused spots as far away as 800 μm with 532 nm light.
On imaging based non-contact tonometer for intraocular pressure measurement (2013)

This article proposes a novel non-contact method of measuring intraocular pressure of human eye using an imaging technique, outside the clinical environment. The method facilitates measurement of intraocular pressure based on differences in the acquired images in the acquired images of a tow flap foils assembly before and after deflation due to an applied air puff of known pressure rebounding from the corneal surface. The flap foil assembly consists of thin black patterned engraved thin transparent flap foils placed between the eye and camera. The reflected air path depends on curvature and stiffness of the corneal surface, which in turn are related to the internal pressure of the eye. This method can be integrated with other optic disc image analysis symptoms of Glaucoma in early stages of screening.
Innovative passivated heterojunction bipolar transistor grown by CBE (1992)

An innovative passivated heterojunction bipolar transistor structure, which enables with the same technological step both base surface passivation and emitter selective etching to be obtained, is reported. This new structure employs an emitter comprising two layers, a thin GaInP layer and a GaAlAs layer.
Macrophage Migration Inhibitory Factor: A Therapeutic Target Across Inflammatory Diseases (2007)

Macrophage migration inhibitory factor (MIF), a cytokine originally reported in the 1960s as the prototypic T lymphokine, has emerged in recent years as a key factor regulating inflammatory responses. Both by directly activating immune cells, and by participating in activation entrained by other stimuli, MIF is important in innate and adaptive immune responses as well as tissue-specific mechanisms of damage. As a consequence of its involvement in multiple stages of the immune-inflammatory response, MIF has the potential to be involved in the pathogenesis of a range of immune-mediated inflammatory diseases affecting multiple organ systems. Diseases in which a role for MIF has been strongly validated include rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, atherosclerosis, asthma, inflammatory liver disease, and most recently systemic lupus erythematosus. Recent data have provided mechanisms of action for MIF which further support its suitability as a therapeutic target. Finally, MIF has a unique relationship with glucocorticoids, acting to counter-regulate their anti-inflammatory effects, such that MIF antagonist therapy may be a direct route to 'steroid-sparing'. Methods of targeting MIF therapeutically have also emerged in recent years, based on the unique protein structure of MIF which affords opportunities for direct antagonism by small molecules, as well as by protein therapeutics such as monoclonal antibodies. Clinical trials of MIF antagonist therapies are likely before the end of the current decade.
The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development. (1994)

The function of the low-affinity nerve growth factor (NGF) receptor, p75NGFR, in regulating neuronal survival during development is unclear. The sensory deficit in mice with mutated p75NGFR suggests it is necessary for development of sensory neurons; however, whether it is required, in addition to trkA, for signal transduction or is more involved in localization of NGF is unresolved. In this study we demonstrate, in vitro, that lowering the levels of p75NGFR expression in sensory neurons with antisense oligonucleotides largely prevents the NGF-mediated survival of sensory neurons from embryonic day 12 and 15 mice but increases the survival of embryonic day 19 and postnatal day 2 sensory neurons in the absence of NGF. Thus, the p75NGFR is required for NGF-mediated survival in neurons at the stage of target innervation but can mediate an apoptotic signal at a later stage of cell development. Thus, p75NGFR undergoes a switch in function in the perinatal period: during embryogenesis it is required, probably with trkA, to mediate neuronal survival in the presence of NGF, but in the early postnatal period it acts as a constitutive death signal in the absence of NGF.
In-situ capacitive sensor for monitoring debris of lubricant oil (2018)

Purpose The purpose of this study is to develop a cylindrical capacitive sensor that has the advantages of high resolution, small size and designability and can be easily installed on lubricant pipeline to monitor lubricant oil debris. Design/methodology/approach A theoretical model of the cylindrical capacitive sensor is presented to analyze several parameters’ effectiveness on the performance of sensor. Numerical simulations are then conducted to determine the optimal parameters for preliminary experiments. Experiments are finally carried out to demonstrate the detectability of developed capacitive sensors. Findings It is clear from experimental results that the developed capacitive sensor can monitor the debris in lubricant oil well, and the capacitance values increase almost linearly when the number and size of debris increase. Research limitations/implications There is lot of further work to do to apply the presented method into the application. Especially, it is necessary to consider several factors’ influence on monitoring results. These factors include the flow rate of the lubricant oil, the temperature, the debris distribution and the vibration. Moreover, future work should consider the influence of the oil degradation to the capacitance change and other contaminations (e.g. water and dust). Practical implications This work conducts a feasibility study on application of capacitive sensing principle for detecting debris in aero engine lubricant oil. Originality/value The novelty of the presented capacitance sensor can be summarized into two aspects. One is that the sensor structure is simple and characterized by two coaxial cylinders as electrodes, while conventional capacitive sensors are composed of two parallel plates as electrodes. The other is that sensing mechanism and physical model of the presented sensor is verified and validated by the simulation and experiment.
A Magnetic Tunnel Junction based True Random Number Generator with conditional perturb and real-time output probability tracking (2014)

This work experimentally demonstrates for the first time a True Random Number Generator (TRNG) based on the random switching probability of Magnetic Tunnel Junctions (MTJs). A conditional perturb and real-time output probability tracking scheme is proposed to enhance the reliability, speed, and power consumption while maintaining a 100% bit efficiency.
Commodity chemicals from natural gas by methane chlorination (1987)

Ethylene and vinyl chloride monomer (VCM) can be produced from natural gas through methane chlorination by reacting methane and chlorine at 900/sup 0/C or higher. Experimental results indicate total ethylene equivalent yield from methane of 45%(wt) and marginal process economics. Fundamental kinetic modeling predicts improved C/sub 2/ yields of up to 70%(wt) at optimum reaction conditions. This optimum condition established the basis for the process design study to evaluate the potential for producing ethylene and VCM from natural gas. HCl by-product is recycled for economic viability. Using the Kel-Chlor process for recycling HCl, the proposed plant produces 27,200 TPA of C/sub 2/H/sub 4/ and 383,800 TPA of VCM. The Midwest is an ethylene consumption area requiring imports of ethylene derivatives from other regions. A methane chlorination plant located on a Midwestern natural gas pipeline network has a good commercial potential.
Demonstration of a 100 Hz repetition rate gain-saturated diode-pumped table-top soft x-ray laser (2012)

We demonstrate the operation of a gain-saturated table-top soft x-ray laser at 100 Hz repetition rate. The laser generates an average power of 0.15 mW at λ=18.9 nm, the highest laser power reported to date from a sub-20-nm wavelength compact source. Picosecond laser pulses of 1.5 μJ energy were produced at λ=18.9 nm by amplification in a Mo plasma created by tailoring the temporal intensity profile of single pump pulses with 1 J energy produced by a diode-pumped chirped pulse amplification Yb:YAG laser. Lasing was also obtained in the 13.9 nm line of Ni-like Ag. These results increase by an order of magnitude the repetition rate of plasma-based soft x-ray lasers opening the path to milliwatt average power table-top lasers at sub-20 nm wavelengths.
Desulfurization of hot fuel with Z-Sorb III sorbent (1993)

The objective of this project is to evaluate regenerable sorbents for potential use in desulfurization of integrated gasification combined cycle (IGCC) fuel gas in a fixed bed operating at temperatures of 900--1200{degree}F (482--649{degree}C) and pressures up to 300--400 psia (2068--2758 kPa). Important evaluation criteria are adequate sulfur absorption capacity, physical and chemical durability, and complete regenerability. The experimental tests were conducted at the Morgantown Energy Technology Center in their high pressure bench-scale hot gas desulfurization unit, which contains a 2 in (5.1 cm) ID reactor system. Like zinc ferrite and zinc titanate, Z-Sorb III is also a zinc oxide-based sorbent supported on a proprietary matrix designed to provide stability and prolong the sorbent life. The test program was divided into four phases. Phase I was essentially a screening or feasibility study and consisted of a relatively short series of complete sulfidation-regeneration cycles. Phase II was a longer term multi-cycle test designed to demonstrate durability and regenerability of the sorbent. Parametric tests of sulfidation variables were done in Phase III. The major variables investigated were gas velocity (0.5--2.0 fps) (0.15--0.61 mps) and absorption temperature (900--1100{degree}F) (482--593{degree}C). Work continued on regeneration techniques during this phase with the purpose of identifying the most cost-effective method for the commercial reactor. Phase IV of the test program was included to examine the effects, if any, of small quantities of HCl in the feed gas. A total of seven cycles were completed. The test program ended with a single sulfidation at the same conditions run during Phase I. This permitted a direct comparison of a relatively fresh sorbent with one that had been subjected to a wide variety of test conditions over an extended period of time.
Summarizing procedures in concurrent programs (2004)

The ability to summarize procedures is fundamental to building scalable interprocedural analyses. For sequential programs, procedure summarization is well-understood and used routinely in a variety of compiler optimizations and software defect-detection tools. However, the benefit of summarization is not available to multithreaded programs, for which a clear notion of summaries has so far remained unarticulated in the research literature.In this paper, we present an intuitive and novel notion of procedure summaries for multithreaded programs. We also present a model checking algorithm for these programs that uses procedure summarization as an essential component. Our algorithm can also be viewed as a precise interprocedural dataflow analysis for multithreaded programs. Our method for procedure summarization is based on the insight that in well-synchronized programs, any computation of a thread can be viewed as a sequence of transactions, each of which appears to execute atomically to other threads. We summarize within each transaction; the summary of a procedure comprises the summaries of all transactions within the procedure. We leverage the theory of reduction [17] to infer boundaries of these transactions.The procedure summaries computed by our algorithm allow reuse of analysis results across different call sites in a multithreaded program, a benefit that has hitherto been available only to sequential programs. Although our algorithm is not guaranteed to terminate on multithreaded programs that use recursion (reachability analysis for multithreaded programs with recursive procedures is undecidable [18]), there is a large class of programs for which our algorithm does terminate. We give a formal characterization of this class, which includes programs that use shared variables, synchronization, and recursion.
Efficacy of <i>Carpophilus</i> aggregation pheromones on nine species in northeastern Ohio, and identification of the pheromone of <i>C. brachypterus</i> (1995)

Abstract Aggregation pheromones for seven Carpophilus (Coleoptera: Nitidulidae) species were field tested at a site with a rich nitidulid fauna in Ohio, USA, during the summers of 1992 and 1993. The pheromones used were blends identified for: Carpophilus antiquus (Melsheimer), C. brachypterus (Say), C. freemani Dobson, C. hemipterus (L.), C. lugubris Murray, C. mutilatus Erichson, and C. obsoletus Erichson. Each pheromone was used in conjunction with whole wheat bread dough, an effective co‐attractant. The pheromone of C. brachypterus Say was identified during the course of this study and was also tested; males emitted a 100:6:11:4:3 blend of (2E, 4E, 6E, 8E)‐3, 5, 7‐trimethyl‐2, 4, 6, 8‐decatetraene, (2E, 4E, 6E, 8E)‐3, 5, 7‐trimethyl‐2, 4, 6, 8‐undecatetraene, (2E, 4E, 6E, 8E)‐7‐ethyl‐3, 5‐dimethyl‐2, 4, 6, 8‐decatetraene, (3E, 5E, 7E, 9E)‐4, 6, 8‐trimethyl‐3, 5, 7, 9‐undecatetraene and (2E, 4E, 6E, 8E)‐7‐ethyl‐3, 5‐dimethyl‐2, 4, 6, 8‐undecatetraene, respectively. All species responded favorably to their own pheromones with the exception of C. obsoletus , which was not present in this area. Strong mutual cross attraction was observed between C. brachypterus and C. hemipterus. In addition, C. lugubris responded to the pheromones of C. obsoletus and C. hemipterus and, more weakly, to those of C. freemani and C. brachypterus ; C. freemani responded slightly to the pheromone of C. mutilatus ; and C. antiquus responded to the pheromone of C. lugubris. In most cases, cross attraction was related to the species involved sharing pheromone components. For C. antiquus , however, the response to the C. lugubris pheromone was apparently kairomonal. C. corticinus, C. marginatus, C. marginellus , and C. sayi , for which pheromones are not known, were attracted to the pheromone of C. lugubris and in some cases to other pheromones. Significant numbers of Colopterus spp. responded to the blends for C. lugubris, C. hemipterus, C. brachypterus , and probably, C. obsoletus.
Aza‐Peptide Epoxides: A New Class of Inhibitors Selective for Clan CD Cysteine Proteases (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Synthesis of New Dihydroindeno[1,2-<i>c</i>]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal Model (2001)

A number of novel dihydroindenoisoquinolines and indenoisoquinolinium salts were synthesized and examined for cytotoxicity in cancer cell cultures and for inhibition of topoisomerase I (top1). The top1-mediated DNA cleavage patterns produced in the presence of several of the new analogues were also investigated, and a few of the more potent compounds were examined for activity in hollow fiber animal models. Very cytotoxic dihydroindenoisoquinoline and isoquinolinium salts were obtained with mean graph midpoints (MGMs) for growth inhibition in the low submicromolar range. Two of the new dihydroindenoisoquinolines were found to be weaker top1 inhibitors than the lead compound 1, while two of the indenoisoquinolinium salts were more potent. The top1-mediated DNA cleavage patterns of the indenoisoquinolines examined were found to be similar to each other but different from that of camptothecin. Several of the more potent indenoisoquinolines displayed promising anticancer activities in hollow fiber animal models.
A Compact eFUSE Programmable Array Memory for SOI CMOS (2007)

Demonstrating a >10X density increase over traditional VLSI fuse circuits, a compact eFUSE programmable array memory configured as a 4 Kb one-time programmable ROM (OTPROM) is presented using a 6.2μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> NiSi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> silicide electromigration 1T1R cell in 65nm SOI CMOS. A 20μs programming time at 1.5V is achieved by asymmetrical scaling of the fuse and a shared differential sensing scheme. Having zero process cost adder, eFUSE is fully compatible with standard VLSI manufacturing.