gebhart/patrepeval huggingface dataset:
Molecular Cloning and Expression of Keratinocyte Proline-rich Protein, a Novel Squamous Epithelial Marker Isolated During Skin Development (2003)

We describe a novel rat cDNA named keratinocyte proline-rich protein (KPRP) isolated by RNA differential display during skin development. We determine that KPRP is expressed in stratified squamous epithelium, and its approximately 2.8-kb cDNA encodes a 699-amino acid protein with high proline content (19%). KPRP is an insoluble protein, similar to most epidermal terminal differentiation-associated proteins. Immunoblot of the protein lysate from keratinocytes, using strong reducing conditions, demonstrates two KPRP bands of approximately 76 and 55 kDa size. KPRP is expressed in stratified squamous epithelia of skin, tongue, and esophagus. The initiation of KPRP expression in fetal rat skin at E17, E18, E19, E20, and E21 was analyzed by reverse transcription-PCR. Fetal skin at E19 and later expresses KPRP. In situ hybridization of skin from E18, E19, and 4-day-old neonatal rats demonstrates that interfollicular and follicular keratinocytes express KPRP. Anti-KPRP antibody demonstrates KPRP protein localizes to all layers of stratified epithelia in skin, tongue, and esophagus. In cultured dermal keratinocytes, KPRP is diffusely distributed throughout the cytoplasm with denser staining adjacent to the nuclear and plasma membranes. Additionally, immunoreactive intracellular granules are observed during keratinocyte detachment from their plastic substrate. Rat KPRP has 89% homology to a mouse genomic DNA sequence and 56% homology to a human hypothetical protein. We conclude that KPRP may be a new epidermal terminal differentiation-related protein expressed in stratified squamous epithelia. KPRP is expressed by fetal dermal keratinocytes during late gestation and is a new marker of maturing epidermis during fetal skin development.
Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1‐phosphate (2010)

Sphingosine 1-phosphate (S1P) in blood is phosphorylated, stored, and transported by red blood cells (RBC). Release of S1P from RBC into plasma is a regulated process that does not occur in plasma- or serum-free media. Plasma fractionation and incubations with isolated and recombinant proteins identified high density lipoprotein (HDL) and serum albumin (SA) as non-redundant endogenous triggers for S1P release from RBC. S1P bound to SA and HDL was able to stimulate the S1P(1) receptor in calcium flux experiments. The binding capability of acceptor molecules triggers S1P release, as demonstrated with the anti-S1P antibody Sphingomab. More S1P was extracted from RBC membranes by HDL than by SA. Blood samples from anemic patients confirmed a reduced capacity for S1P release in plasma. In co-cultures of RBC and endothelial cells (EC), we observed transcellular transportation of S1P as a second function of RBC-associated S1P in the absence of SA and HDL and during tight RBC-EC contact, mimicking conditions in tissue interstitium and capillaries. In contrast to S1P bound to SA and HDL, RBC-associated S1P was significantly incorporated by EC after S1P lyase (SGPL1) inhibition. RBC-associated S1P, therefore, has two functions: (1) It contributes to the cellular pool of SGPL1-sensitive S1P in tissues after transcellular transportation and (2) it helps maintain extracellular S1P levels via SA and HDL independently from SGPL1 activity.
Superresolution of Fourier transform spectroscopy data by the maximum entropy method (1983)

The maximum entropy method (MEM) is applied to the interferogram data obtained using the technique of Fourier transform spectroscopy for estimating its spectrum with a resolution far exceeding the value set by the spectrometer. For emission line data, the MEM process is directly used with the interferogram data in place of the regular Fourier transformation process required in Fourier transform spectroscopy. It produces a spectral estimate with an enhanced resolution. For absorption data with a broad background spectrum, the method is applied to a modified interferogram which corresponds to the Fourier transform of the absorptance spectrum. Two results are presented to demonstrate the power of the technique: for the visible emission spectrum of a spectral calibration lamp and for the infrared chloroform absorption spectrum. Included in the paper is a discussion of the problems associated with practical use of the MEM.
The conical shape filament growth model in unipolar resistance switching of TiO2 thin film (2009)

This study examined the relationship between the conducting filament resistance and reset voltage during the resistance switching of TiO2 thin films assuming a filament with a conical shape. There was a critical resistance (∼20 Ω) of the set state above and below which the filament responded differently in response to the current. Maintaining a higher set state resistance was more beneficial in achieving a more uniform reset voltage. This filament model coincides well with the localized switching behavior and the recently microscopically observed filament shape.
Practicing precision medicine with intelligently integrative clinical and multi-omics data analysis (2020)

Precision medicine aims to empower clinicians to predict the most appropriate course of action for patients with complex diseases like cancer, diabetes, cardiomyopathy, and COVID-19. With a progressive interpretation of the clinical, molecular, and genomic factors at play in diseases, more effective and personalized medical treatments are anticipated for many disorders. Understanding patient's metabolomics and genetic make-up in conjunction with clinical data will significantly lead to determining predisposition, diagnostic, prognostic, and predictive biomarkers and paths ultimately providing optimal and personalized care for diverse, and targeted chronic and acute diseases. In clinical settings, we need to timely model clinical and multi-omics data to find statistical patterns across millions of features to identify underlying biologic pathways, modifiable risk factors, and actionable information that support early detection and prevention of complex disorders, and development of new therapies for better patient care. It is important to calculate quantitative phenotype measurements, evaluate variants in unique genes and interpret using ACMG guidelines, find frequency of pathogenic and likely pathogenic variants without disease indicators, and observe autosomal recessive carriers with a phenotype manifestation in metabolome. Next, ensuring security to reconcile noise, we need to build and train machine-learning prognostic models to meaningfully process multisource heterogeneous data to identify high-risk rare variants and make medically relevant predictions. The goal, today, is to facilitate implementation of mainstream precision medicine to improve the traditional symptom-driven practice of medicine, and allow earlier interventions using predictive diagnostics and tailoring better-personalized treatments. We strongly recommend automated implementation of cutting-edge technologies, utilizing machine learning (ML) and artificial intelligence (AI) approaches for the multimodal data aggregation, multifactor examination, development of knowledgebase of clinical predictors for decision support, and best strategies for dealing with relevant ethical issues.
Experimental tumor targeting with radiolabeled ligands (1997)

Approaches have been developed in animal models to increase
Redaktören har ordet (2014)

Sociologisk Forsknings digitala arkiv
Peritoneal Inflammation after Twenty-Week Exposure to Dialysis Solution: Effect of Solution versus Catheter–Foreign Body Reaction (2010)

An indwelling catheter amplifies peritoneal inflammation from dialysis solutions through a foreign body reaction. Our data also suggest that additives to existing solutions may have limited the effect on inflammatory response to non-biocompatible solutions.
Diagnosis and subtyping of depressive disorders by quantitative electroencephalography: III. Discriminating unipolar from bipolar depression. (1988)

One hundred fifty-two inpatient major depressives fulfilled the Research Diagnostic Criteria for unipolar (N = 111) or bipolar (N = 41) affective disorder. After at least seven days drug-free, all patients had a thyrotropin releasing hormone stimulation test (TRHST), a dexamethasone suppression test (DST) and quantitative electroencephalography (QEEG). Multivariate analysis of variance was used to compare post-dexamethasone cortisol, delta TSH, six regional QEEG measures of interhemispheric symmetry and six focal measures of QEEG frequency. Age, sex and diagnosis were included in the analysis. Unipolar depressives were discriminated from bipolar depressives by age, delta TSH and QEEG fast wave abnormalities in the alpha and beta frequency bands. Unipolar depressives were significantly older, had lower mean delta TSH, showed excessive alpha activity and deficient beta activity. Bipolar depressives were younger, had higher mean delta TSH, showed a deficit of alpha activity and excessive beta activity. Unipolar might be discriminable from bipolar major depression by the use of two objective procedures--TRHST and QEEG. The two disorders appear to be biochemical and electrophysiological opposites. Treatment implications are discussed.
Intrinsic birefringence of poly(trimethylene terephthalate) (2002)

Abstract Highly oriented poly(trimethylene terephthalate) (PTT) fiber has a low birefringence that is unexpected for an aromatic polyester with a high refractive index. To explain this observation, the intrinsic birefringence Δ n of PTT crystal was calculated from its bond polarizabilities to be 0.029. This Δ n is almost an order of magnitude smaller than poly(ethylene terephthalate)'s value at 0.22, although both polymers have nearly identical crystal refractive indices. The small Δ n is due to the arrangement of PTT's methylene groups in gauche conformations, causing the chain‐repeating unit to be tilted ∼53° away from the c axis toward the basal plane. Because of the small Δ n , the crystalline‐phase orientation made only a small contribution to the overall birefringence despite the fiber's high crystallinity and orientation. To understand the effect of the number of methylene groups on polyester optical anisotropy, the Δ n 's of a series of poly( m ‐alkylene terephthalates) with m = 2–5 were compared and correlated with ψ: an angle made by the normal of the benzene ring with the crystal's axis. As ψ′ decreases, Δ n of the polyesters diminishes. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 40: 1513–1520, 2002
REDUCED INTER- AND INTRASUBJECT VARIABILITY IN CYCLOSPORINE PHARMACOKINETICS IN RENAL TRANSPLANT RECIPIENTS TREATED WITH A MICROEMULSION FORMULATION IN CONJUNCTION WITH FASTING, LOW-FAT MEALS, OR HIGH-FAT MEALS1,2 (1995)

This cross-over study compared the pharmacokinetic parameters obtained from cyclosporine (CsA) concentration-time profiles after administration of the corn oil-based soft gel cap (CsA-GC) with those with the microemulsion (CsA-ME) gel cap. Neither the fasting state nor the coadministration of a low- or high-fat breakfast affected the pharmacokinetics of CsA presented in either formulation. Comparisons of the three sets of pharmacokinetic parameters—namely, after fasting or after low-fat or after high-fat diets—demonstrated the CsA-ME formulation to display greater intraindividual reproducibility of the C0 and C12 trough levels (TLs), Cmax, tmax, and area under the concentration-time curve (AUC) than the CsA-GC formulation. Although the degree of interindividual variation in AUC, Cmax and tmax after CsA-ME administration was slightly, but significantly, less than after CsA-GC administration, there was no difference between the two formulations in terms of the customarily monitored C0 or C12 TL values. CsA-ME showed higher correlation coefficients of drug exposure (AUC) with C12 than CsA-GC (0.910 versus 0.712). However, CsA-ME administration resulted in only modest improvement over CsA-GC administration in the relationships between drug dose and C0, C12, or AUC—namely, 0.645 versus 0.496, 0.611 versus 0.517, and 0.700 versus 0.501, respectively. Correlation analysis between individual timed samples and AUC determinations revealed that CsA-ME requires significantly less frequent blood monitoring for prediction of total drug exposure than does CsA-GC. Although the clinical utility of this reproducible pharmacokinetic behavior remains to be demonstrated in the de novo transplant setting, the markedly reduced intraindividual variation produced by administration of CsA-ME will likely improve the accuracy of pretransplant prediction of, and reduce the frequencey of subsequent adjustments in, CsA doses.
Preparation of Nd-Doped SiO<sub>2</sub> Glass by Plasma Torch CVD (1982)

Silica glass has not been fully characterized as a host material for glass lasers. To evaluate the intrinsic fluorescent characteristics of Nd-doped SiO 2 glass, a plasma torch CVD system was specially designed for the preparation of clear high purity glasses. Both of the observed fluorescences of Nd 3+ ( 4 F 3/2 – 4 I 9/2 and 4 F 3/2 – 4 I 11/2 ) consist of a fast (τ≃0.35 µs) and a slow (τ≃450 µs) decay component. The spectral features and intensity of the former remarkably depend on Nd concentration and preparation conditions, while those of the latter are similar in every sample and its fluorescence peak positions distinctly shift to a wavelength longer than those observed in ordinary multicomponent glasses.
Broadband Information Broadcasting Using LED-Based Interior Lighting (2008)

Emergence of white-light LEDs allows the combination of lighting and information broadcast functionality in one optical source. We investigate analytically and by Monte Carlo simulations feasible data transmission rates in a moderate-size office room, where we assume illumination conforming to standards and the use of commercially available LEDs and photodiodes. The performances of systems relying on baseband [i.e., pulse-amplitude modulation (PAM)] and discrete multitone (DMT) transmission show that data rates of more than 100 Mbit/s can be expected despite the rather low bandwidth of the system.
Pick your precursor! Tailoring the size and crystal phase of microwave-synthesized sub-10 nm upconverting nanoparticles (2019)

The influence of precursor chemistry on thermal decomposition and particle growth in a rapid microwave-assisted strategy was investigated, demonstrating the selective synthesis of small and ultrasmall luminescent lanthanide-doped NaGdF<sub>4</sub> nanoparticles.
A Study of Anxiety Disorders in Terms of Severity and Prevalence in Patients of Major Depressive Disorder in a Tertiary Care Centre (2018)

Background: Depression is a disorder of major public health importance. Over the last 50 years, large number of studies have been published from India addressing various aspects of depression. The objective of the current study was to study the socio-demographic characteristics and anxiety as co-morbidity in patients with major depressive disorder. Method: This was a cross sectional study conducted in tertiary care hospital in which 100 patients diagnosed with major depressive disorder, according to ICD-10 were assessed for presence of anxiety disorder as psychiatric Comorbidity using MINI and severity of anxiety was assessed using HAM-A. Results: Current study showed major depressive disorder is more common among females 59%, married 79%, housewife 50%, 61% had first episode of depression and 27% had family history of major depressive disorder. There was 48% presence of any anxiety disorder among total major depressive disorder patients. Among which 25% had generalized anxiety disorder, 9% obsessive compulsive disorder, 5% panic disorder, 4% agoraphobia, 4% post traumatic stress disorder and 1% social anxiety disorder among total patients with major depressive disorder. The maximum number of patients 43% had mild to moderate level of anxiety, 32% had mild anxiety, 19% had moderate to severe anxiety and 6% had severe anxiety. Conclusion: There is a high prevalence of anxiety disorders in major depressive disorder which is oftenly ignored because of symptom overlap between anxiety and major depression. This study is important because of increasing prevalence of psychiatric comorbidity among the patients of major depressive disorders lead to impaired functioning in patients with MDD. Therefore, monitoring of symptoms as well as functioning during the long-term management MDD could be crucial to achieve the functioning remission.
An Unconventional Diacylglycerol Kinase That Regulates Phospholipid Synthesis and Nuclear Membrane Growth (2008)

Changes in nuclear size and shape during the cell cycle or during development require coordinated nuclear membrane remodeling, but the underlying molecular events are largely unknown. We have shown previously that the activity of the conserved phosphatidate phosphatase Pah1p/Smp2p regulates nuclear structure in yeast by controlling phospholipid synthesis and membrane biogenesis at the nuclear envelope. Two screens for novel regulators of phosphatidate led to the identification of DGK1. We show that Dgk1p is a unique diacylglycerol kinase that uses CTP, instead of ATP, to generate phosphatidate. DGK1 counteracts the activity of PAH1 at the nuclear envelope by controlling phosphatidate levels. Overexpression of DGK1 causes the appearance of phosphatidate-enriched membranes around the nucleus and leads to its expansion, without proliferating the cortical endoplasmic reticulum membrane. Mutations that decrease phosphatidate levels decrease nuclear membrane growth in pah1Delta cells. We propose that phosphatidate metabolism is a critical factor determining nuclear structure by regulating nuclear membrane biogenesis.
Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable β-amyloid deposition (2004)

Environmental enrichment (EE) has been shown to improve cognitive performance and brain indices of cognition in normal mice and rats. Because the therapeutic potential of intensive, long-term EE to benefit patients with Alzheimer's disease (AD) has yet to be explored, the present study evaluated the effect of long-term EE on cognition in an animal model of AD, the APPsw transgenic mouse. Beginning at 16 months of age, APPsw mice were put into EE or standard housing for 4 months and then tested in four cognitive-based tasks (Morris maze, circular platform, platform recognition, and radial arm water maze) between 20 and 22 months of age. Our results indicate that long-term EE of aged APPsw mice results in global, overall improvement in cognitive function across these tasks without decreasing brain beta-amyloid (A beta) deposition. The results suggest that long-term EE/cognitive stimulation could provide cognitive stabilization or improvement to AD patients through mechanisms independent of A beta deposition and clearance.
ADHD diagnosis in children using Common spatial pattern and Nonlinear Analysis of Filter banked EEG (2020)

Attention Deficit Hyperactivity Disorder (ADHD) is currently the most common neuropsychiatric disorder of childhood, which is marked by abnormalities in hyperactivity, inattention, and impulsivity stages. Early diagnosis of ADHD may effectively reduce the symptoms and side effects of this disorder. Recording and analysis of Electroencephalogram (EEG) is one of the proper functional methods to detect such disorders, which merits independency from subjects variability. This study considers classification of ADHD and healthy subjects by using EEG signals and temporal and frequency features such as common spatial pattern (CSP), selective nonlinear attributes, and through usage of filter banks and time windowing approaches. In order to evaluate our proposed method, we applied it on a benchmark dataset, namely NBML, which consists of 328 epochs of recorded EEG signals from 61 subjects in two classes of ADHD and healthy. The proposed method achieved the discrimination accuracy of 83.33% of the two classes by using the proposed KNN classifier, which proved superior to previously reported results on the same dataset.
Communications in IEC 61850 Based Substation Automation Systems (2006)

IEC 61850 is the new standard for communications in substations that defines process bus and substation bus communications allowing the development of new distributed applications for protection, control and automation. The paper describes the different communications related to the implementation of the new standard. It also discusses performance requirements for the various substation functions
A UNIFIED APPROACH TO PARAMETRIC GEOCODING AND ATMOSPHERIC/TOPOGRAPHIC CORRECTION FOR WIDE FOV AIRBORNE IMAGERY PART 1 : PARAMETRIC ORTHO-RECTIFICATION PROCESS (2000)

A combined geometric and radiometric processing chain for hyperspectral data is presented. This paper describes the ortho-rectification solution for the geometric part of the whole problem. A parametric geocoding approach (PARGE) has been chosen. The geometrical model strictly considers all navigational parameters engaging a forward transformation methodology. For the implementation, a number of auxiliary data calibration and tuning possibilities are shown together with the work flow of the currently applied processor. Results of the procedure for HyMap and AVIRIS hyperspectral imagery are analyzed with respect to their absolute accuracy and coregistration errors. The geocoding procedure will be used in standard preprocessing chains in combination with the atmospheric correction procedure ATCOR4 for current and future hyperspectral instruments. 1
Water channels in platelet volume regulation (2011)

The regulation of platelet volume significantly affects its function. Because water is the major molecule in cells and its active transport via water channels called aquaporins (AQPs) have been implicated in cellular and organelle volume regulation, the presence of water channels in platelets and their potential role in platelet volume regulation was investigated. G-protein-mediated AQP regulation in secretory vesicle swelling has previously been reported in neurons and in pancreatic acinar cells. Mercuric chloride has been demonstrated to inhibit most AQPs except AQP6, which is stimulated by the compound. Exposure of platelets to HgCl(2)-induced swelling in a dose-dependent manner, suggesting the presence of AQP6 in platelets. Immunoblot analysis of platelet protein confirmed the presence of AQP6, and also of G(αo), G(αi-1) and G(αi-3) proteins. Results from this study demonstrate for the first time that in platelets AQP6 is involved in cell volume regulation via a G-protein-mediated pathway.
Upsampling Real-Time, Low-Resolution CCTV Videos Using Generative Adversarial Networks (2020)

Video super-resolution has become an emerging topic in the field of machine learning. The generative adversarial network is a framework that is widely used to develop solutions for low-resolution videos. Video surveillance using closed-circuit television (CCTV) is significant in every field, all over the world. A common problem with CCTV videos is sudden video loss or poor quality. In this paper, we propose a generative adversarial network that implements spatio-temporal generators and discriminators to enhance real-time low-resolution CCTV videos to high-resolution. The proposed model considers both foreground and background motion of a CCTV video and effectively models the spatial and temporal consistency from low-resolution video frames to generate high-resolution videos. Quantitative and qualitative experiments on benchmark datasets, including Kinetics-700, UCF101, HMDB51 and IITH_Helmet2, showed that our model outperforms the existing GAN models for video super-resolution.