gebhart/patrepeval huggingface dataset:
Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2 (2014)

Polycomb Repressive Complex 2 (PRC2) modulates the chromatin structure and transcriptional repression by trimethylation lysine 27 of histone H3 (H3K27me3), a process that necessitates the protein-protein interaction (PPI) between the catalytic subunit EZH2 and EED. Deregulated PRC2 is intimately involved in tumorigenesis and progression, making it an invaluable target for epigenetic cancer therapy. However, until now, there have been no reported small molecule compounds targeting the EZH2-EED interactions. In the present study, we identified astemizole, an FDA-approved drug, as a small molecule inhibitor of the EZH2-EED interaction of PRC2. The disruption of the EZH2-EED interaction by astemizole destabilizes the PRC2 complex and inhibits its methyltransferase activity in cancer cells. Multiple lines of evidence have demonstrated that astemizole arrests the proliferation of PRC2-driven lymphomas primarily by disabling the PRC2 complex. Our findings demonstrate the chemical tractability of the difficult PPI target by a small molecule compound, highlighting the therapeutic promise for PRC2-driven human cancers via targeted destruction of the EZH2-EED complex.
The Recognition Motif of the Glycoprotein-Folding Sensor Enzyme UDP-Glc:Glycoprotein Glucosyltransferase (2009)

The folding of glycoproteins is primarily mediated by a quality control system in the ER, in which UDP-Glc:glycoprotein glucosyltransferase (UGGT) serves as a "folding sensor". In this system, client glycoproteins are delivered to UGGT after the trimming of their innermost glucose residue by glucosidase II, which releases them from the lectin chaperones calnexin (CNX) and calreticulin (CRT). UGGT is inactive against folded proteins, allowing them to proceed to the Golgi apparatus for further processing to complex- or hybrid-type glycoforms. On the other hand, this enzyme efficiently glucosylates incompletely folded glycoproteins to monoglucosylated structures, providing them with an opportunity to interact with CNX/CRT. In order to clarify the mode of this enzyme's substrate recognition, we conducted a structure-activity relationship study using a series of synthetic probes. The inhibitory activities of various glycans suggest that UGGT has a strong affinity for the core pentasaccharide (Man3GlcNAc2) of high-mannose-type glycans. Our comparison of the reactivity of acceptors that have been modified by various aglycons supports the hypothesis that UGGT recognizes the hydrophobic region of client glycoproteins. Moreover, we discovered fluorescently labeled substrates that will be valuable for highly sensitive detection of UGGT activity.
Physicochemical and functional properties of rye nonstarch polysaccharides. II. Impact of a fraction containing water-soluble pentosans and proteins on gluten-starch loaf volumes (1991)

Rye water-soluble protein-pentosan fractions improve the volume of gluten-starch loaves. Ferulic acid residues of the water-soluble pentosans of rye or wheat were not involved in the interactions leading to larger loaf volumes because removal of these moieties or the addition of an excess of ferulic acid in the baking formula did not impair the role of the rye protein-pentosan material in gluten-starch systems. The action of the nonstarch polysaccharides probably is related to an increase in dough viscosity
Anti-bacteroides lipopolysaccharide IgG levels in healthy adults and sepsis patients (1995)

Members of the genus Bacteroides greatly outnumber enterobacteria in the human colon and therefore represent a vast potential pool of biologically active LPS. An enzyme-linked immunosorbent assay was developed to estimate the distribution of IgG levels to LPS from B. fragilis, B. vulgatus, B. thetaiotaomicron and to a mixture of rough LPS from three enterobacteria and Pseudomonas aeruginosa in sera from 641 adult blood donors. By inhibition ELISA some cross-reactivity was demonstrated between the different anti-bacteroides LPS IgG, but with very little between the anti-bacteroides LPS IgG and the anti-enterobacterial/Pseudomonas LPS IgG. Serum IgG was measured daily over 5-9 day periods in 12 sepsis patients (6 survivors, 6 non-survivors) and in a healthy individual. In all patients IgG levels fluctuated to a greater extent than levels in a healthy subject. Variations all followed similar overall trends and indicated that exposure to bacteroides LPS had occurred. In 5 out of 6 survivors, IgG levels were rising at the end of the period, while 4 of the 6 non-survivors showed falls, with an exception showing increasing levels to B. fragilis LPS. In 5 out of 6 non-survivors, IgG levels against B. fragilis LPS were substantially higher than those against the other LPSs. In this small sample some trends in antibody kinetics have been recognised which suggest bacteroides LPS may be significant in sepsis, and indicate that this study should be extended.
Locus of emotion influences psychophysiological reactions to music (2020)

It is now widely accepted that the perception of emotional expression in music can be vastly different from the feelings evoked by it. However, less understood is how the locus of emotion affects the experience of music, that is how the act of perceiving the emotion in music compares with the act of assessing the emotion induced in the listener by the music. In the current study, we compared these two emotion loci based on the psychophysiological response of 40 participants listening to 32 musical excerpts taken from movie soundtracks. Facial electromyography, skin conductance, respiration and heart rate were continuously measured while participants were required to assess either the emotion expressed by, or the emotion they felt in response to the music. Using linear mixed effects models, we found a higher mean response in psychophysiological measures for the "perceived" than the "felt" task. This result suggested that the focus on one's self distracts from the music, leading to weaker bodily reactions during the "felt" task. In contrast, paying attention to the expression of the music and consequently to changes in timbre, loudness and harmonic progression enhances bodily reactions. This study has methodological implications for emotion induction research using psychophysiology and the conceptualization of emotion loci. Firstly, different tasks can elicit different psychophysiological responses to the same stimulus and secondly, both tasks elicit bodily responses to music. The latter finding questions the possibility of a listener taking on a purely cognitive mode when evaluating emotion expression.
Sustained Drug Release on Temperature-responsive Polymer Hybrid Nanoporous Silica Composites (2004)

Received April 12, 2004 orthosilicate (TEOS) was added into the solution at 40 °C. The mixture was aged in a bomb at 120 °C overnight without stirring. The solid product was filtered, washed with excess water, and air-dried at room temperature. Calcination was carried out at 550 °C for 6 hours. The PNIPAm hybridized nanoporous materials were prepared by the radical-initiated polymerization with NIPAm monomers and 2,2'-azobis(isobutyronitrile) (AIBN) with ammonium sulfate on (3-(methacryloyloxy)propyl)trimethoxysilane (3-MOP) modified nanoporous silica surface after modification of MOP on ordered nanoporous silicas with different pore sizes (10, 17, 30 nm) synthesized (Scheme 1). The dried PNIPAm hybrid nanoporous materials were immersed in a saturated solution of indomethacin in EtOH-water (8 : 2, v/v) over- night and dried over a period of 3 days at room temperature. The drug-loaded composites of the PNIPAm hybrid nano- porous silicas were immersed in 10 mL of phosphate buffer (PBS, pH 7.4, 10 mM). Solutions containing the drug-loaded composites were shaken in temperature-controlled shaker for stepwise temperature changes between 25 °C and 40 °C. The indomethacin concentration of the solution was measured using a UV-Vis. spectrophotometer (257 nm) at
Real-time signal processing on low-cost-FPGAs using dynamic partial reconfiguration (2011)

The limited number of logic elements makes the implementation of signal processing chains on low-cost FPGAs a challenging task. In order to allow the implementation of complex designs on devices with limited resources, we propose the subpartitioning of a processing chain into several modules, which are loaded and executed in a round-robin fashion using dynamic partial reconfiguration (DPR) of FPGAs. The DPR architecture requires input data pre-buffering which introduces delay. These circumstances are first considered in a theoretical analysis and later applied to a broadcast receiver chain, where the benefits and drawbacks of the architecture are highlighted.
Time-Resolved EPR, Fluorescence, and Transient Absorption Studies on Phthalocyaninatosilicon Covalently Linked to One or Two TEMPO Radicals (2001)

The photophysical properties of tetra-tert-butylphthalocyaninatosilicon (SiPc) covalently linked to one or two 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) radicals (R1, R2) have been studied by fluorescence, transient absorption, and time-resolved electron paramagnetic resonance (TREPR) spectroscopies. It is found that the fluorescence quantum yields and lifetimes of R1 and R2 decrease compared with those of (dihydroxy)SiPc ((dihydroxy)SiPc = 6.8 ns, R1 = 4.7 ns and 42 ps, and R2 = 4.7 ns and <30 ps). Transient absorption measurements indicate that the lifetime of the excited triplet SiPc is markedly dependent on the number of linking TEMPO radicals ((dihydroxy)SiPc = 500 micros, R1 = 7.6 micros, and R2 = 3.7 micros). These short lifetimes of R1 and R2 in the excited states are explained as a result of the interaction with TEMPO changing the ISC between the singlet and triplet states to spin-allowed transitions. Quantitative TREPR investigations have been carried out for the radical-quartet pair mechanism of R1 and the photoinduced population transfer of R2. It is determined that the rise and decay times of these electron spin polarizations denote the spin-lattice relaxation time of the ground state and the lifetime of the excited multiplet state, respectively. This study contributes not only to an elucidation of radical-chromophore interactions but also to a novel approach for controlling magnetic properties by photoexcitation.
PP.24.12 (2015)

Objective: Hypertensive disorders of pregnancy such as preeclampsia (PE) remain a leading cause of maternal and fetal morbidity and mortality. The prediction of the course of PE still is a clinical challenge. Accumulating evidence indicates that the plasma levels of soluble Fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) are markedly altered in PE. We evaluate the potential value of sFlt-1, PlGF and their ratio in diagnosing PE, predicting the development of adverse pregnancy outcomes and to get to know if there is any valuable information of these markers in the differential diagnosis of different phenotypes of PE. Design and method: The aim of this prospective multicenter cohort study is to include 600 women suspected of PE. Blood is drawn at admission and the sFlt-1 and PlGF are measured post partum to prevent any influence of this information on decision-making of the treating physicians and the defining time point of delivery. Shortly after the general blood test, according to clinical presentation and the regular laboratory data, the doctor estimated what the test results meant for the prolongation of the pregnancy, the severity of preeclampsia as well for the likelihood of the development of preeclampsia during the pregnancy. Afterwards we analyzed the correlation of the serum concentrations with the remaining time-to-delivery. Results: Preliminary results for a total of 44 women are available: 17 with normal pregnancy outcome, 3 patients with HELLP, 3 with gestational hypertension (GH) and 21 with PE including 2 samples of superimposed PE. The sFlt-1/PlGF ratio was significantly increased in patients with both early- (< 34 wks) as late onset (>34 wks) PE/HELLP in comparison to controls and GH. PlGF seemed to be more related to fetal outcomes compared to sFlt-1. A ratio of > 85 associated with delivery within 15 days and appeared to be a better predictor of prolongation of the pregnancy than a doctor's prediction of the prolongation. Conclusions: A high sFlt-1/PlGF ratio is associated with PE/HELLP and has a significantly increased risk for delivery within 15 days.
Orientation Residual Stresses and Birefringence in Injection Molding (1983)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. Greener, G. H. Pearson; Orientation Residual Stresses and Birefringence in Injection Molding. J. Rheol. 1 April 1983; 27 (2): 115–134. https://doi.org/10.1122/1.549701 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages (2015)

ChemR23 is a G protein-coupled receptor that is triggered by two ligands, the peptide chemerin and the eicosapentaenoic acid-derived lipid mediator resolvin E1 (RvE1). Chemerin acts as a chemoattractant for monocytes and macrophages, whereas RvE1 promotes resolution of inflammation-inducing macrophage phagocytosis of apoptotic neutrophils. Although ChemR23-mediated signaling plays a role in mononuclear cell migration to inflamed tissue, as well as in the resolution of inflammation, its regulation in different polarization states of macrophages is largely unknown. We analyzed the expression and function of ChemR23 in monocytes and differently activated human primary macrophages. Using 5' RACE, we identified three transcription start sites and several splice variants of ChemR23 in both monocytes and macrophages. Although the promoters P1 and P3 are used equally in unpolarized macrophages, stimulation with LPS or IFN-γ leads to increased transcription from P3 in inflammatory M1 macrophages. Such ChemR23-expressing M1 macrophages are chemotactic to chemerin, whereas M2 macrophages not expressing ChemR23 surface receptor are not. Repolarization of ChemR23-expressing M1 macrophages with 10 nM RvE1 increases IL-10 transcription and phagocytosis of microbial particles, leading to a resolution-type macrophage distinct from the M2 phenotype. These results show that ChemR23 is tightly regulated in response to inflammatory and anti-inflammatory stimuli. The restricted expression of ChemR23 in naive and M1 macrophages supports the role of ChemR23 in the attraction of macrophages to inflamed tissue by chemerin and in the initiation of resolution of inflammation through RvE1-mediated repolarization of human M1 macrophages toward resolution-type macrophages.
Development of an enzyme-linked immunosorbent assay for geosmin (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment of an enzyme-linked immunosorbent assay for geosminSi Yin Chung, John R. Vercellotti, Peter B. Johnsen, and Phillip H. KlesiusCite this: J. Agric. Food Chem. 1991, 39, 4, 764–769Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://doi.org/10.1021/jf00004a030RIGHTS & PERMISSIONSArticle Views203Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (696 KB) Get e-Alerts Get e-Alerts
An Airfoil Diffuser With Variable Stagger and Solidity for Centrifugal Compressor Applications (2007)

Airfoil diffusers have been extensively used in industrial centrifugal compressors. However, the majority of these diffusers are two-dimensional and have fixed solidity. This paper presents a numerical investigation of a new three-dimensional airfoil diffuser, i.e. variable stagger, which has a varying solidity in the span wise direction. The premise of this configuration is to better align the diffuser blade with the non uniform flow leaving the compressor impeller as well as to combine the benefits of the known wide operating range of the low solidity diffusers with the high performance of the high solidity diffusers. Numerical simulations of several impeller-diffuser configurations are presented. The first configuration uses a three-dimensional variable solidity airfoil diffuser while the others use conventional diffusers with different solidities. The results of the simulations are presented in terms of the aerodynamic performance of both the impeller and diffusers as well as the overall stage performance. The analysis indicates that the three dimensionality of the flow path of the proposed diffuser greatly impacts the diffuser as well as the impeller aerodynamic performance. The analysis also indicates the superiority of the proposed new diffuser geometry over the analyzed conventional airfoil diffusers in extending the operating range of the compressor stage as well as improving its efficiency.
How do plant virus nucleic acids move through intercellular connections? (1991)

In addition to their function in transport of water, ions, small metabolites, and growth factors in normal plant tissue, the plasmodesmata presumably serve as routes for cell-to-cell movement of plant viruses in infected tissue. Virus cell-to-cell spread through plasmodesmata is an active process mediated by specialized virus encoded movement proteins; however, the mechanism by which these proteins operate is not clear. We incorporate recent information on the biochemical properties of plant virus movement proteins and their interaction with plasmodesmata in a model for transport of nucleic acids through plasmodesmatal channels. We propose that only single stranded (ss) nucleic acids can be transported efficiently through plasmodesmata, and that movement proteins function as molecular chaperones for ss nucleic acids to form unfolded movement protein-ss nucleic acid complexes. These complexes are targeted to plasmodesmata. Plasmodesmatal permeability is then increased following interaction with movement protein and the entire movement complex or its nucleic acid component is translocated across the plasmodesmatal channel.
Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study (2017)

Concentrated 2 mg intranasal naloxone is well-absorbed and provides early exposure comparable to 0.4 mg intramuscular naloxone, following the 0.4 mg intramuscular curve closely in the first 10 minutes post-dosing and maintaining blood levels above twice the intramuscular reference for the next 2 hours.
A new methodology for fuzzy control based on weighted fuzzy logics. (1993)

This paper presents a weighted fuzzy reasoning technique for fuzzy control based on weighted fuzzy logics, where fuzzy production rules are used for knowledge representation. The technique allows the truth values of the conditions appearing in the antecedent portions of the rules, the certainty factors of the rules, and the weights of the conditions appearing in the antecedent portions of the rules to be linguistic terms represented by trapezoidal fuzzy numbers. >
Effect of Crop Geometry, Cultivars and Weed Management on Weed Growth and Yield of Chickpea (2003)

Field experiments were conducted to study the effect of two crop geometry, three cultivars and two weed management treatments on weed and crop growth, and yield of chickpea during winter seasons of 1996–97 and 1997–98 at Agricultural Research Farm, Banaras Hindu University, Varanasi. Row spacing of 45 cm recorded lower plant height and more crop canopy cover and weed dry matter accumulation than 30 cm row spacing. Avarodhi had the maximum plant height, canopy cover and less weed dry weight than Radhey and Pant G 114. Weedy check recorded more plant height and more weed dry matter accumulation as compared to weed-free treatment. Row spacing of 45 cm recorded more grain yield in comparison to 30 cm row spacing. The maximum grain yield was recorded in cultivar Avarodhi and minimum in Pant G 114 during both the years.
Comparison of Free and Total Forms of Serum Human Kallikrein 2 and Prostate-Specific Antigen for Prediction of Locally Advanced and Recurrent Prostate Cancer (2006)

Increased concentrations of hK2 in the blood are significantly associated with unfavorable features of prostate cancer, and thK2 is predictive of locally advanced and recurrent cancer in patients with PSA < or =10 microg/L. Independent of tPSA and fPSA, hK2 predicts unfavorable prognosis.
Using blockchain technology for file synchronization (2019)

Abstract Modern storage technology has shifted from traditional offline state to cloud based technology since some time now. Because of this transition, the present society is now more dependent on the online storage solutions. Synchronization of files and keeping a history of changes are critical parts of any cloud system. Therefore, an implementation of Blockchain Technology with traditional file synchronization and versioning system can be extremely fruitful. Blockchain is not a new technology, but recently its importance has sky-rocketed as the society is moving towards the decentralized World Wide Web. Blockchain is “an open, distributed ledger that can record transactions between two parties efficiently and in a verifiable and permanent way” [1]. Blockchain provides immutable data storage and access with the combination of Proof-of-Work [2, 3]. Due to such appealing features, the study undertaken here investigates and proposes a Blockchain based resilient cloud storage solution that makes a sound utilization of various properties fundamental to any Blockchain based framework.
Nanoantenna for Electrical Generation of Surface Plasmon Polaritons (2016)

Light emission by inelastic tunneling has been known for many years. Recently, this technique has been used to generate surface plasmons using a scanning tunneling microscope tip. The emission process suffers from a very low efficiency lower than a photon in 10^{4} electrons. We introduce a resonant plasmonic nanoantenna that allows both enhancing the power conversion to surface plasmon polaritons by more than 2 orders of magnitude and narrowing the emission spectrum. The physics of the emission process is analyzed in terms of local density of states and the efficiency of the nanoantenna to radiate surface plasmon polaritons.
DBLP (2009)

The DBLP Computer Science Bibliography evolved from an early small experimental Web server to a popular service for the computer science community. Many design decisions and details of the public XML-records behind DBLP never were documented. This paper is a review of the evolution of DBLP. The main perspective is data modeling. In DBLP persons play a central role, our discussion of person names may be applicable to many other data bases. All DBLP data are available for your own experiments. You may either download the complete set, or use a simple XML-based API described in an online appendix.