gebhart/patrepeval huggingface dataset:
Comparison of Magnetic Resonance Imaging and Lumbar Discography in the Diagnosis of Disc Degeneration (1990)

A prospective comparison of 97 discs in 50 patients studied by both magnetic resonance imaging and discography showed a high correlation in the identification of the degenerative disc between these two modalities.
Development of Polyoxyethylene Zwitterionic Surfactants for High‐Salinity High‐Temperature Reservoirs (2019)

Abstract Substantial efforts are underway to improve the recovery factor from existing oil reserves to meet the ever‐growing global oil demand. Surfactants are known to increase oil recovery through reducing interfacial tension (IFT) and/or altering the rock wettability. The selection of surfactants for high‐salinity high‐temperature oil fields is a challenging task owing to poor thermal stability, precipitation, and adsorption of surfactants on reservoir rocks. Sulfobetaine‐based polyoxyethylene zwitterionic surfactants have shown excellent thermal and surface properties. However, their solubility in high‐salinity brines becomes poor particularly with a long hydrophobic tail (>C17). Recently, we synthesized such types of surfactants by incorporating ethylene oxide (EO) units into the hydrophobic tail, which improved the solubility in formation water (213,734 ppm) and seawater (SW) (57,643 ppm). In this work, we investigated the IFT, thermal stability, rheological behavior, and foaming properties of two polyoxyethylene zwitterionic surfactants having different degrees of ethoxylation. Aging experiments exhibited excellent thermal stability and no change in the chemical structure was detected. The surfactant with lesser EO units (EASB‐1a) showed a lower IFT compared to the surfactant with higher EO units (EASB‐1b). Rheological studies revealed that the addition of both surfactants reduced the viscosity of the acrylamide copolymer. However, the effect of EASB‐1a was more prominent compared to that of EASB‐1b. The surfactant with a higher degree of ethoxylation showed lower adsorption compared to the surfactant with a lesser degree of ethoxylation. Both surfactants showed excellent foamability and foam stability compared to the commercial surfactants. Excellent thermal stability, water solubility under harsh reservoir conditions, foaming properties, and lower adsorption make them a suitable choice for high‐temperature, high‐salinity reservoirs.
TRPV1 Activation Is Required for Hypertonicity-Stimulated Inflammatory Cytokine Release in Human Corneal Epithelial Cells (2010)

Hypertonic stress-elicited TRPV1 channel stimulation mediates increases in a proinflammatory cytokine IL-6 and a chemoattractant IL-8 by eliciting EGFR transactivation, MAPK, and NF-κB activation. Selective drug modulation of either TRPV1 activity or its signaling mediators may yield a novel approach to suppressing inflammatory responses occurring in dry eye syndrome.
Sarampión en Chile 1960-1985 (2017)

El efecto inmediato mÃ¡s destacado del programa de vacunaciÃ³n es la notable caÃ­da de la tasa de morbilidad y la virtual eliminaciÃ³n de las muertes causadas por sarampiÃ³n. Persiste, sin embargo, un remanente de casos y continÃºan ocurriendo brotes esporÃ¡dicos de magnitud variable. Ha habido, ademÃ¡s, como efecto tardÃ­o no esperado, un desplazamiento paulatino de las denuncias hacia edades mayores que vaticinan su importancia relativa creciente en el adulto. Los hechos seÃ±alados serÃ­an consecuencia de la persistencia de "susceptibles residuales" cuyos incrementos periÃ³dicos dan origen a brotes cada vez que alcanzan un cifra crÃ­tica.
Self-Learning by Word Localization from Images (2014)

Artificial Intelligence is an interdisciplinary research area which aims at making the machines more human. Extensive research is going on to teach them to perform the tasks. Deep learning is a collection of algorithms in Machine Learning. In this paper we implement deep learning for learning and gaining the knowledge of the text from real time images. An algorithm namely word localization is proposed to able to make the machine to understand the words extracted from the images. In comparison with traditional Optical character recognition (OCR) it has many advantages over it which is been analyzed.
Linear ubiquitination: A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex [Review] (2012)

The NF-κB pathway is a central signaling pathway for inflammatory and immune responses, and aberrant NF-κB signaling is implicated multiple disorders, such as cancer and autoimmune, chronic inflammatory and metabolic diseases. NF-κB is regulated by various post-translational modifications, including phosphorylation and multiple ubiquitinations. We determined that LUBAC (linear ubiquitin chain assembly complex), composed of SHARPIN, HOIL-IL and HOIP, generates a novel type of Met1-linked linear polyubiquitin chain and specifically regulates the canonical NF-κB pathway via the linear ubiquitination of NEMO and RIP1. In the absence of LUBAC components, NF-κB signaling was attenuated and induced apoptosis and inflammation. Many studies on the pathophysiological functions of LUBAC, such as in B cell development, innate immune response, carcinogenesis, and osteogenesis, have been performed recently. This review summarizes these new findings on LUBAC- and linear ubiquitination-mediated NF-κB regulation and their implications in disorders.
HMMEditor: a visual editing tool for profile hidden Markov model (2008)

HMMEditor provides a set of unique functions to visualize and edit a profile HMM. It is a useful tool for biological sequence analysis and modeling. Both HMMEditor software and web service are freely available.
An all-digital phase-locked loop (ADPLL)-based clock recovery circuit (1999)

A new algorithm for all-digital phase-locked loops (ADPLL) with fast acquisition and large pulling range is presented in this paper. Based on the proposed algorithm, portable cell-based implementations for clock recovery with functions of a frequency synthesizer and on-chip clock generator are completed by standard cell. These modules have been designed and verified on a 0.6-/spl mu/m CMOS process. Test results are summarized as follows: 1) the proposed ADPLL can satisfy full locked bandwidth and fast acquisition within one data transition; 2) the on-chip clock generator can generate any target clock rate f/sub clock/; and 3) the function of nonreturn-to-zero clock recovery has a maximum f/sub clock//4 recovering capability with a locking range of (/spl tau//sub input//spl plusmn//spl tau//sub input//2)) where /spl tau//sub input/ is the input period.
The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified AnalogsPanayiotis A. Procopiou, Esme J. Bailey, Mark J. Bamford, Andy P. Craven, Brian W. Dymock, John G. Houston, Julie L. Hutson, Barrie E. Kirk, Alun D. McCarthy, and Cite this: J. Med. Chem. 1994, 37, 20, 3274–3281Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jm00046a011https://doi.org/10.1021/jm00046a011research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Targeting HOX transcription factors in prostate cancer (2014)

Many HOX genes are highly over-expressed in prostate cancer, and prostate cancer cells are sensitive to killing by HXR9 both in vitro and in vivo. The HOX genes are therefore a potential therapeutic target in prostate cancer.
Unusual seedless approach to gold nanoparticle synthesis: application to selective rapid naked eye detection of mercury(<scp>ii</scp>) (2014)

We report a novel seedless Hg(2+)-induced synthetic approach for the preparation of gold nanostructures. This protocol is demonstrated for the highly selective and sensitive naked eye detection of Hg(2+) based on the high affinity metallophilic Hg(2+)-Au(+) interaction. The response time upon exposure to Hg(2+) is almost instantaneous.
Magnetoresistance in an All‐Organic‐Based Spin Valve (2011)

Spin injection/detection in an all-organic-based spin valve is experimentally demonstrated. The magnetoresistance is explained by a bias-enhanced selective tunneling model. This can potentially be used to develop light-weight, flexible, low-cost spintronic devices.
Deriving electrical dependencies from circuit topologies using logic grammar (2010)

In this paper, a new logic grammar for knowledge representation of electronic circuits has been developed. The grammar rules not only define the syntactic structure of electronic circuits, but also allow us to derive the meaning of a given circuit as relationships between its syntactic structure and basic circuit functions. This paper shows how voltage and current dependencies are coded in this new circuit grammar and how these dependencies are derived by parsing circuit topologies.
Real or Virtual: A Video Conferencing Background Manipulation-Detection System (2022)

Recently, the popularity and wide use of the last-generation video conferencing technologies created an exponential growth in its market size. Such technology allows participants in different geographic regions to have a virtual face-to-face meeting. Additionally, it enables users to employ a virtual background to conceal their own environment due to privacy concerns or to reduce distractions, particularly in professional settings. Nevertheless, in scenarios where the users should not hide their actual locations, they may mislead other participants by claiming their virtual background as a real one. Therefore, it is crucial to develop tools and strategies to detect the authenticity of the considered virtual background. In this paper, we present a detection strategy to distinguish between real and virtual video conferencing user backgrounds. We demonstrate that our detector is robust against two attack scenarios. The first scenario considers the case where the detector is unaware about the attacks and inn the second scenario, we make the detector aware of the adversarial attacks, which we refer to Adversarial Multimedia Forensics (i.e, the forensically-edited frames are included in the training set). Given the lack of publicly available dataset of virtual and real backgrounds for video conferencing, we created our own dataset and made them publicly available [1]. Then, we demonstrate the robustness of our detector against different adversarial attacks that the adversary considers. Ultimately, our detector's performance is significant against the CRSPAM1372 [2] features, and post-processing operations such as geometric transformations with different quality factors that the attacker may choose. Moreover, our performance results shows that we can perfectly identify a real from a virtual background with an accuracy of 99.80%.
Sunlight‐Induced Cross‐Linked Luminescent Films Based on Polysiloxanes and <scp>d</scp>‐Limonene via Thiol–ene “Click” Chemistry (2015)

The increasing pursuit of biocontained elastic materials led the investigation of the potential use of the monoterpene limonene in film synthesis via thiol–ene reaction. Poly[(mercaptopropyl)methylsiloxane] (PMMS) is first synthesized. By controlling the molar ratio of PMMS and functional monomers, such as polyethylene glycol allyl methyl ether or rhodamine‐B, PMMS is partially functionalized while leaving spare mercapto groups that could be further used as cross‐linking sites. On the basis of the functionalized PMMS, novel transparent silicone luminescent films with hydrophilic tunable properties are prepared by natural‐sunlight‐triggered thiol–ene “click” chemistry by using d ‐limonene as a cross‐linker. Their structures and properties are thoroughly characterized. Transparent luminescent films are coated on commercially available UV‐light emitting diode (LED) cell from solution medium followed by an in situ cross‐linking step; a colorful LED cell is obtained through this facile and efficient method. The UV‐LED coated by films show very intense photoluminescence under normal visible light or the light is on, and has very high coloric purity.
Leveraging semantic web search and browse sessions for multi-turn spoken dialog systems (2014)

Training statistical dialog models in spoken dialog systems (SDS) requires large amounts of annotated data. The lack of scalable methods for data mining and annotation poses a significant hurdle for state-of-the-art statistical dialog managers. This paper presents an approach that directly leverage billions of web search and browse sessions to overcome this hurdle. The key insight is that task completion through web search and browse sessions is (a) predictable and (b) generalizes to spoken dialog task completion. The new method automatically mines behavioral search and browse patterns from web logs and translates them into spoken dialog models. We experiment with naturally occurring spoken dialogs and large scale web logs. Our session-based models outperform the state-of-the-art method for entity extraction task in SDS. We also achieve better performance for both entity and relation extraction on web search queries when compared with nontrivial baselines.
Vibrational spectra of YbBiGeO<sub>5</sub> (2002)

Abstract The infrared and Raman spectra of YbBiGeO 5 were recorded and are briefly discussed on the basis of its structural peculiarities. The infrared spectra of the complete series of isostructural LnBiGeO 5 compounds (Ln = Dy–Lu and Y) were also recorded and some comparisons with related species are made. Copyright © 2002 John Wiley & Sons, Ltd.
Genetic Variants of SARS-CoV-2—What Do They Mean? (2021)

This Viewpoint discusses emerging genetic variants of SARS-CoV-2, including new “UK” and “mink” variants and the significance of the new variants to coronavirus transmissibility, spread, virulence, and efforts to vaccinate the population against COVID-19.
Simultaneous MR knee image segmentation and bias field correction using deep learning and partial convolution (2019)

Intensity inhomogeneity is a great challenge for automated organ segmentation in magnetic resonance (MR) images. Many segmentation methods fail to deliver satisfactory results when the images are corrupted by a bias field. Although inhomogeneity correction methods exist, they often fail to remove the bias field completely in knee MR images. We present a new iterative approach that simultaneously predicts the segmentation mask of knee structures using a 3D U-net and estimates the bias field in 3D MR knee images using partial convolution operations. First, the test images run through a trained 3D U-net to generate a preliminary segmentation result, which is then fed to the partial convolution filter to create a preliminary estimation of the bias field using the segmented bone mask. Finally, the estimated bias field is then used to produce bias field corrected images as the new inputs to the 3D U-net. Through this loop, the segmentation results and bias field correction are iteratively improved. The proposed method was evaluated on 20 proton-density (PD)-weighted knee MRI scans with manually created segmentation ground truth using 10 fold cross-validation. In our preliminary experiments, the proposed methods outperformed conventional inhomogeneity-correction-plus-segmentation setup in terms of both segmentation accuracy and speed.
Integration of DNA fragments by illegitimate recombination in Saccharomyces cerevisiae. (2021)

DNA fragments (generated by BamHI treatment) with no homology to the yeast genome were transformed into Saccharomyces cerevisiae. When the fragments were transformed in the presence of the BamHI enzyme, they integrated into genomic BamHI sites. When the fragments were transformed in the absence of the enzyme, they integrated into genomic G-A-T-C sites. Since the G-A-T-C sequence is present at the ends of BamHI fragments, this result indicates that four base pairs of homology are sufficient for some types of mitotic recombination
Development of the 25-list-item National Eye Institute Visual Function Questionnaire (2001)

The reliability and validity of the NEI VFQ-25 are comparable to those of the 51-item NEI VFQ field test version of the survey. This shorter version will be more feasible in settings such as clinical trials where interview length is a critical consideration. In addition, preliminary analyses indicate that the psychometric properties of the NEI VFQ-25 are robust for the eye conditions studied; this suggests that the measure will provide reproducible and valid data when used across multiple conditions of varying severity.
miRNA Profiling Discriminates Types of Rejection and Injury in Human Renal Allografts (2013)

These data suggest that distinct miRNA signatures playing a role in specific biological pathways discriminate acute cellular and humoral rejection and DGF. This finding serves as valuable tool for a rational selection of diagnostic, prognostic, and potentially therapeutic molecular targets of posttransplantation events.
Fabrication of relaxed InGaN pseudo-substrates composed of micron-sized pattern arrays with high fill factors using porous GaN (2019)

Abstract Fully or partially relaxed micron-sized InGaN patterns with fill factors up to 69% were demonstrated via porosification of the underlying GaN:Si layer. The impact of the porosification etch conditions and the pattern geometry on the degree of InGaN relaxation were studied and monitored via high resolution x-ray diffraction reciprocal space maps. Additionally, a 45 nm redshift in the photoluminescence emission from In x Ga 1− x N/ In y Ga 1− y N multi-quantum wells (MQWs) regrown on bi-axially relaxed InGaN buffer layers was observed when compared to a co-loaded reference sample grown on GaN. The longer emission wavelength was associated with higher indium incorporation into the InGaN layers deposited on the InGaN base layers with a lattice constant larger than GaN, due to the reduced lattice mismatch between MQW and InGaN base layer, also called compositional pulling effect.
Introducing GEOPHIRES v1.0: Software Package for Estimating Levelized Cost of Electricity and/or Heat from Enhanced Geothermal Systems (2013)

A new computer-based model has been developed to evaluate the levelized cost of electricity and/or directuse heat from Enhanced Geothermal Systems (EGS). This software upgrades and expands the “MIT-EGS” model used in the 2006 “Future of Geothermal Energy” study. The upgrades include implementation of the latest geothermal well drilling and power plant cost submodels as well as incorporation of production wellbore heat losses. The main expansion consists of implementing different end-uses, i.e. electricity, direct-use, or combined heat & power (CHP). The new model “GEOthermal energy for the Production of Heat and Electricity Economically Simulated” (GEOPHIRES) can be used either as a stand-alone program or as a subroutine to be called from another program, e.g. MATLAB. GEOPHIRES has the option to either simulate an EGS reservoir and power plant for given parameters, or optimize their design, operating parameters and drilling depth to yield minimum levelized cost. Two case studies were analyzed. The first one provides an estimate of the levelized cost of electricity and direct-use heat with EGS, which is compared with predictions from the widely used GETEM (Geothermal Electricity Technology Evaluation Model). The second case study develops a supply curve for geothermal energy district heating using EGS for the states of New York and Pennsylvania – which are representative areas for low-enthalpy geothermal energy resources in the U.S.
Unsupervised learning of an IS-A taxonomy from a limited domain-specific corpus (2015)

Taxonomies hierarchically organize concepts in a domain. Building and maintaining them by hand is a tedious and time-consuming task. This paper proposes a novel, unsupervised algorithm for auto-matically learning an IS-A taxonomy from scratch by analyzing a given text corpus. Our approach is designed to deal with infrequently occurring con-cepts, so it can effectively induce taxonomies even from small corpora. Algorithmically, the approach makes two important contributions. First, it per-forms inference based on clustering and the distri-butional semantics, which can capture links among concepts never mentioned together. Second, it uses a novel graph-based algorithm to detect and remove incorrect is-a relations from a taxonomy. An em-pirical evaluation on five corpora demonstrates the utility of our proposed approach. 1
SREBP-1-independent regulation of lipogenic gene expression in adipocytes (2007)

Sterol regulatory element-binding protein (SREBP)-1c is now well established as a key transcription factor for the regulation of lipogenic enzyme genes such as FAS in hepatocytes. Meanwhile, the mechanisms of lipogenic gene regulation in adipocytes remain unclear. Here, we demonstrate that those in adipocytes are independent of SREBP-1c. In adipocytes, unlike in hepatocytes, the stimulation of SREBP-1c expression by liver X receptor agonist does not accompany lipogenic gene upregulation, although nuclear SREBP-1c protein is concomitantly increased, indicating that the activation process of SREBP-1c by the cleavage system is intact in adipocytes. Supportively, transcriptional activity of the mature form of SREBP-1c for the FAS promoter was negligible when measured by reporter analysis. As an underlying mechanism, accessibility of SREBP-1c to the functional elements was involved, because chromatin immunoprecipitation assays revealed that SREBP-1c does not bind to the functional SRE/E-box site on the FAS promoter in adipocytes. Moreover, genetic disruption of SREBP-1 did not cause any changes in lipogenic gene expression in adipose tissue. In summary, in adipocytes, unlike in hepatocytes, increments in nuclear SREBP-1c are not accompanied by transactivation of lipogenic genes; thus, SREBP-1c is not committed to the regulation of lipogenesis.
Isolation of gene fusions (soi::lacZ) inducible by oxidative stress in Escherichia coli. (1988)

Mu dX phage was used to isolate three gene fusions to the lacZ gene (soi::lacZ; soi for superoxide radical inducible) that were induced by treatment with superoxide radical anion generators such as paraquat and plumbagin. The induction of beta-galactosidase in these fusion strains with the superoxide radical generating agents required aerobic metabolism. Hyperoxygenation (i.e., bubbling of cultures with oxygen gas) also induced the fusions. On the other hand, hydrogen peroxide did not induce the fusions at concentrations that are known to invoke an adaptive response. Introduction of oxyR, htpR, or recA mutations did not affect the induction. Two of the fusion strains exhibited increased sensitivity to paraquat but not to hydrogen peroxide. The third fusion strain showed no increased sensitivity to either agent. All three fusions were located in the 45- to 61-min region of the Escherichia coli chromosome.