gebhart/patrepeval huggingface dataset:
A Surface Plasmon Resonance Sensor with a V-Shaped Silicon Prism Array (2006)

A surface plasmon resonance (SPR) sensor with a prism array made by silicon microfabrication techniques is proposed. We fabricated silicon prisms arrayed in 200 µ m in pitch by anisotropic wet etching for deflecting light. We measured SPR curves in specimen of air, water and ethanol using near-infrared laser light (1550 nm) and obtained the SPR dip in each measurement. We fabricated a flexible flap, which was actuated by Lorentz force, to change the incident angle. The silicon prism chip was attached on the flap, the SPR curve was measured by scanning the incident angle of laser light with the flap.
MR elastography of the breast:preliminary clinical results (2002)

We conclude that MRE is a promising new imaging modality with the capability to assess the viscoelastic properties of breast tumors and the surrounding tissues. However, from our preliminary results in a small number of patients it is obvious that there is an overlap in the elasticity ranges of soft malignant tumors and stiff benign lesions.
Nefertiti: a query by content software for three-dimensional models databases management (2002)

This paper presents a new approach for the classification and retrieval of three-dimensional images and models from databases. A set of retrieval algorithms is introduced. These algorithms are content-based, meaning that the input is not made out of keywords but of three-dimensional models. Tensor of inertia, distribution of normals, distribution of cords and multiresolution analysis are used to describe each model. The database can be searched by scale, shape or color or any combination of these parameters. A user friendly interface makes the retrieval operation simple and intuitive and allows to edit reference models according to the specifications of the user. Experimental results using a database of more than 400 range images and 1000 VRML models are presented.
Exploring the IEEE Standard C37.118–2005 Synchrophasors for Power Systems (2008)

IEEE Standard 1344-1995 [1] on measurement of synchronized phasors of power system currents and voltages has been revised and published as IEEE Standard C37.118-2005 [2]. This paper has been prepared by the IEEE Working Group who developed the revised version. The purpose of the paper is to acquaint the power engineering community of the availability and content of this new standard, highlight some of the key differences between the old and new versions, and introduce several applications of this powerful technology.
Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry (2008)

Gene expression changes are a hallmark of the neuropathology of Huntington's disease (HD), but the exact molecular mechanisms of this effect remain uncertain. Here, we report that in vitro models of disease comprised of primary striatal neurons expressing N-terminal fragments of mutant huntingtin (via lentiviral gene delivery) faithfully reproduce the gene expression changes seen in human HD. Neither viral infection nor unrelated (enhanced green fluorescent protein) transgene expression had a major effect on resultant RNA profiles. Expression of a wild-type fragment of huntingtin [htt171-18Q] also caused only a small number of RNA changes. The disease-related signal in htt171-82Q versus htt171-18Q comparisons was far greater, resulting in the differential detection of 20% of all mRNA probe sets. Transcriptomic effects of mutated htt171 are time- and polyglutamine-length dependent and occur in parallel with other manifestations of polyglutamine toxicity over 4-8 weeks. Specific RNA changes in htt171-82Q-expressing striatal cells accurately recapitulated those observed in human HD caudate and included decreases in PENK (proenkephalin), RGS4 (regulator of G-protein signaling 4), dopamine D(1) receptor (DRD1), DRD2, CNR1 (cannabinoid CB(1) receptor), and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein-32; also known as PPP1R1B) mRNAs. HD-related transcriptomic changes were also observed in primary neurons expressing a longer fragment of mutant huntingtin (htt853-82Q). The gene expression changes observed in cultured striatal neurons are not secondary to abnormalities of neuronal firing or glutamatergic, dopaminergic, or brain-derived neurotrophic factor signaling, thereby demonstrating that HD-induced dysregulation of the striatal transcriptome might be attributed to intrinsic effects of mutant huntingtin.
Tightly coupled UWB/IMU pose estimation (2009)

In this paper we propose a 6DOF tracking system combining Ultra-Wideband measurements with low-cost MEMS inertial measurements. A tightly coupled system is developed which estimates position as well as orientation of the sensor-unit while being reliable in case of multipath effects and NLOS conditions. The experimental results show robust and continuous tracking in a realistic indoor positioning scenario.
Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus (2013)

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the development of therapeutic agents, we screened 230 new mouse anti-CHIKV monoclonal antibodies (MAbs) for their ability to inhibit infection of all three CHIKV genotypes. Four of 36 neutralizing MAbs (CHK-102, CHK-152, CHK-166, and CHK-263) provided complete protection against lethality as prophylaxis in highly susceptible immunocompromised mice lacking the type I IFN receptor (Ifnar(-/-) ) and mapped to distinct epitopes on the E1 and E2 structural proteins. CHK-152, the most protective MAb, was humanized, shown to block viral fusion, and require Fc effector function for optimal activity in vivo. In post-exposure therapeutic trials, administration of a single dose of a combination of two neutralizing MAbs (CHK-102+CHK-152 or CHK-166+CHK-152) limited the development of resistance and protected immunocompromised mice against disease when given 24 to 36 hours before CHIKV-induced death. Selected pairs of highly neutralizing MAbs may be a promising treatment option for CHIKV in humans.
Characterization of a protein C activator from the venom of Agkistrodon contortrix contortrix (1988)

An enzyme capable of activating protein C has been purified 60-fold from the venom of the Southern copperhead snake (Agkistrodon contortrix) by ion-exchange and gel filtration chromatography. The purified enzyme consists of a single polypeptide with an apparent molecular weight of 37,000. The isoelectric point of the protein C activator was determined to be 6.3 when measured by chromatofocusing. The enzyme was inhibited by p-nitrophenyl p-guanidinobenzoate, phenylmethanesulfonyl fluoride, and D-Phe-Pro-Arg-CH2Cl but was not affected by cysteine-directed reagents or by metal chelators. These results suggest that the enzyme is a serine protease. Protein C activator was capable of hydrolyzing the thrombin substrate tosyl-Gly-Pro-Arg-p-nitroanilide (TGPRpNA), and steady-state kinetic studies determined that the Km for amidolysis of this substrate was 1.1 mM while the Vmax was 66 s-1. The activator demonstrated considerable substrate specificity since the amidolysis of D-Phe-Pip-Arg-pNA, D-Ile-Pro-Arg-pNA, Bz-Ile-Glu-Gly-Arg-pNA, D-Val-Leu-Arg-pNA, and pyrGlu-Pro-Arg-pNA was less than 10% of that of TGPRpNA when measured under identical conditions using 1.0 mM substrate concentrations. The enzyme appears to be thrombin-like in its preference for arginyl as compared to lysyl chloromethyl ketones as well as by its inhibition by benzamidine and p-aminobenzamidine. However, the substrate specificity of the activator is distinguished from alpha-thrombin in that it does not clot fibrinogen and does not react with antithrombin III or hirudin.(ABSTRACT TRUNCATED AT 250 WORDS)
Photonic True-Time Delay Beamforming Based on Polarization-Domain Interferometers (2010)

In this paper, we propose a novel photonic true-time delay beamforming system for phased array antennas. The system relies on tunable delay lines which are based on Mach-Zehnder delay interferometers (MZDIs) with tunable coupling ratio. As the MZDIs are implemented on the polarization domain, a single optical source and a single piece of polarization maintaining fiber are required. The proposed implementation is theoretically assessed and beam squinting is investigated by simulation. A proof-of-concept experiment that validates the operation principle of the proposed delay lines is presented.
The Potential and Properties of Sulfur Concretes (1982)

Sulphur concretes have been used for low-cost housing in developing countries and have potential for various other applications. Field trials have been conducted of sulphur-based curbs and gutters, sewer pipes, median barriers, linings for acid containers and road bases. Recent research has been concentrated on stress-strain behaviour, durability in environments aggressive to portland cement concrete, and durability in cycles of freezing and thawing. Various researchers have used different approaches in attempts to solve performance problems. Polymerization of the sulphur in a pre-mix operation has produced strong durable concretes with age-dependent stress-strain behaviours. Additives which alter intercrystalline and sulphur-aggregate boundaries have also been used: strain softening materials are obtained at the expense of strength. Mix design has also received attention. Strength is sensitive to mix design and the techniques used for asphaltic and portland cement concretes are not directly applicable. In the paper, the advantages of the different approaches to the problems are examined. New data are also presented and interpreted with previous results to provide a comprehensive view of sulphur concrete behaviour.
Geometrical transformations in optics* (1974)

Optical techniques are introduced for performing general types of map transformations. Geometrical image modifications like coordinate transformations and local translation, inversion, reflection, stretching, and rotation require highly space-variant systems. Filters can be introduced into optical coherent systems in such a way that their local phase variations are able to influence light from local object areas. Experimental results of typical optical geometrical transformations like conformal mapping of object distributions are presented. Another capability of this technique is to image a specific, arbitrary surface onto another surface of general shape.
Authenticating a mobile device's location using voice signatures (2012)

Providers of location-based services seek new methods to authenticate the location of their clients. We propose a novel infrastructure-based solution that provides spontaneous and transaction-oriented mobile device location authentication via an integrated 802.11× wireless access point and 3G femtocell access system. By simply making a voice call while remotely monitoring femtocell activity, a calling party can verify a (co-operating) called party's location even when the participants have no pre-existing relationship. We show how such a traffic signature can be reliably detected even in the presence of heavy cross-traffic introduced by other femtocell users. We describe how the verification proceeds without revealing details of the authentication - or even the parties involved - to the location provider.
Continuous-time marginal pricing of electricity (2017)

The current practice of discrete-time electricity pricing starts to fall short in providing an accurate economic signal reflecting the continuous-time variations of load and generation schedule in power systems. This paper introduces the fundamental mathematical theory of continuous-time marginal electricity pricing. We first formulate the continuous-time unit commitment (UC) problem as a constrained variational problem, and subsequently define the continuous-time economic dispatch (ED) problem where the binary commitment variables are fixed to their optimal values. We then prove that the continuous-time marginal electricity price equals to the Lagrange multiplier of the variational power balance constraint in the continuous-time ED problem. The proposed continuous-time marginal price is not only dependent to the incremental generation cost rate, but also to the incremental ramping cost rate of the units, thus embedding the ramping costs in calculation of the marginal electricity price. The numerical results demonstrate that the continuous-time marginal price manifests the behavior of the constantly varying load and generation schedule in power systems.
Synthesis and Structure-Activity Relationships of Novel Nor-Seco Analogs of Taxol and Taxotere (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Structure-Activity Relationships of Novel Nor-Seco Analogs of Taxol and TaxotereIwao Ojima, Ivana Fenoglio, Young Hoon Park, Chung Ming Sun, Giovanni Appendino, Ralph J. Bernacki, and Paula PeraCite this: J. Org. Chem. 1994, 59, 3, 515–517Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/jo00082a003https://doi.org/10.1021/jo00082a003research-articleACS PublicationsRequest reuse permissionsArticle Views258Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Study on Electroreduction Mechanism of Aromatic Dicarboxylic Acids. Electrosynthesis of 1,4-Benzenedimethanol (1988)

Abstract The electroreduction mechanisms of terephthalic acid and isophthalic acid in acidic solution were studied by molecular orbital (MO) calculations. Further, a practical stepwise route to 1,4-benzenedimethanol has been developed by the electroreduction of p-(hydroxymethyl) benzoic acid.
Improving Existing Fault Recovery Policies (2009)

An automated recovery system is a key component in a large data center. Such a system typically employs a hand-made controller created by an expert. While such controllers capture many important aspects of the recovery process, they are often not systematically optimized to reduce costs such as server downtime. In this paper we describe a passive policy learning approach for improving existing recovery policies without exploration. We explain how to use data gathered from the interactions of the hand-made controller with the system, to create an improved controller. We suggest learning an indefinite horizon Partially Observable Markov Decision Process, a model for decision making under uncertainty, and solve it using a point-based algorithm. We describe the complete process, starting with data gathering, model learning, model checking procedures, and computing a policy. 1
B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure (2019)

We describe a robust semiquantitative histologic B cell score that closely replicates the quantification of B cells by digital or molecular analyses. Our findings indicate an ongoing B cell-rich synovitis, which does not seem to be captured by standard clinimetric assessment, in a larger proportion of patients with established RA than early RA.
Further analysis of the sequence of the S1 subunit of pertussis toxin (1991)

The two published sequences of the pertussis toxin operon differ in 3 bp in the S1 subunit gene. In this report, we provide evidence that Bordetella pertussis strains are able to produce active pertussis toxin only when they contain one of the two possible nucleotide sequences.
<title>Experiments in MPEG-4 content authoring, browsing, and streaming</title> (2000)

In this paper, within the context of the MPEG-4 standard we report on preliminary experiments in three areas -- authoring of MPEG-4 content, a player/browser for MPEG-4 content, and streaming of MPEG-4 content. MPEG-4 is a new standard for coding of audiovisual objects; the core of MPEG-4 standard is complete while amendments are in various stages of completion. MPEG-4 addresses compression of audio and visual objects, their integration by scene description, and interactivity of users with such objects. MPEG-4 scene description is based on VRML like language for 3D scenes, extended to 2D scenes, and supports integration of 2D and 3D scenes. This scene description language is called BIFS. First, we introduce the basic concepts behind BIFS and then show with an example, textual authoring of different components needed to describe an audiovisual scene in BIFS; the textual BIFS is then saved as compressed binary file/s for storage or transmission. Then, we discuss a high level design of an MPEG-4 player/browser that uses the main components from authoring such as encoded BIFS stream, media files it refers to, and multiplexed object descriptor stream to play an MPEG-4 scene. We also discuss our extensions to such a player/browser. Finally, we present our work in streaming of MPEG-4 -- the payload format, modification to client MPEG-4 player/browser, server-side infrastructure and example content used in our MPEG-4 streaming experiments.
Application of reduced state estimation to multisensor fusion with out-of-sequence measurements (2004)

A filtering application of processing multisensor measurements with delays is considered. Because of delays, measurements fed by geographically dispersed sensors to a processing site may arrive out of time sequence. Unlike smoothing or filtering, optimal processing of an out-of-sequence measurement is not a standard problem in filtering theory for which a definitive approach has yet to be developed. An optimal reduced state estimator, derived in previous work, is applied to this problem. A simulation example of multisensor fusion is presented, in which one sensor feeds highly accurate, but delayed, measurements to be fused with a second sensor's less accurate measurements having no delay. We demonstrate a uniform improvement in performance for this algorithm over two traditional approaches.
Efficient algorithms to solve Bayesian Stackelberg games for security applications (2008)

In a class of games known as Stackelberg games, one agent (the leader) must commit to a strategy that can be observed by the other agent (the adversary/follower) before the adversary chooses its own strategy. We consider Bayesian Stackelberg games, in which the leader is uncertain about the type of the adversary it may face. Such games are important in security domains, where, for example, a security agent (leader) must commit to a strategy of patrolling certain areas, and an adversary (follower) can observe this strategy over time before choosing where to attack. We present here two different MIP-formulations, ASAP (providing approximate policies with controlled randomization) and DOBSS (providing optimal policies) for Bayesian Stackelberg games. DOBSS is currently the fastest optimal procedure for Bayesian Stackelberg games and is in use by police at the Los Angeles International Airport(LAX) to schedule their activities.
Nickel metal hydride: ready to serve (1998)

With their impressive energy performance and their outstanding power capability, Ni-MH batteries are equally suitable for use in pure and hybrid electric vehicles. This is due to the basic nickel-metal hydride technology. For one thing, hydrogen can be stored in metal-hydride alloys at very high volumetric densities, comparable to the density in liquid hydrogen, leading to the superior energy density of metal-hydride batteries. The operating principles of the Ni-MH battery are described as is their construction and manufacture. The on-road performance of Ni-MH batteries and hybrid electric vehicle batteries are discussed.
Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides:  Charting a Workable Structure−Activity Relationship Using Simple Prototypes (2005)

This paper describes the discovery of synthetic 1,2,4-trioxolane antimalarials and how we established a workable structure-activity relationship in the context of physicochemical, biopharmaceutical, and toxicological profiling. An achiral dispiro-1,2,4-trioxolane (3) in which the trioxolane is flanked by a spiroadamantane and spirocyclohexane was rapidly identified as a lead compound. Nonperoxidic 1,3-dioxolane isosteres of 3 were inactive as were trioxolanes without the spiroadamantane. The trioxolanes were substantially less effective in a standard oral suspension formulation compared to a solubilizing formulation and were more active when administered subcutaneously than orally, both of which suggest substantial biopharmaceutical liabilities. Nonetheless, despite their limited oral bioavailability, the more lipophilic trioxolanes generally had better oral activity than their more polar counterparts. In pharmacokinetic experiments, four trioxolanes had high plasma clearance values, suggesting a potential metabolic instability. The toxicological profiles of two trioxolanes were comparable to that of artesunate.
Characterization of Radioiodinated TISCH: A High‐Affinity and Selective Ligand for Mapping CNS D<sub>1</sub> Dopamine Receptor (1992)

In developing CNS D1 dopamine receptor-imaging agents with improved specificity and longer brain retention, an iodinated D1 ligand was synthesized. In vitro and in vivo radiolabeling studies of a new iodinated benzazepine, TISCH [7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine], an analog of SCH 23390 (7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin e), were investigated. After an intravenous injection, the R(+) isomer of TISCH showed high brain uptake in rats (2.20 and 0.57% dose per whole brain at 2 and 60 min, respectively). The striatum/cerebellum ratio increased progressively with time (12 at 60 min). Ex vivo autoradiography of rat brain sections, after intravenous injection of R(+)-[125I]TISCH, displayed the highest uptake in striatum and substantia nigra, regions known to have a high concentration of D1 receptors, whereas the S(-) isomer displayed no specific uptake. Furthermore, the specific uptake can be blocked by pretreatment with SCH 23390. In vitro binding studies using the rat striatum tissue preparation showed high specific and low nonspecific bindings (KD = 0.21 +/- 0.03 nM). The rank order of potency exhibiting high specificity to the D1 receptor was SCH 23390 greater than (+/-)-TISCH greater than (+)-butaclamol = (+/-)-FISCH [7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1 H-3-benzazepine] much greater than WB4101 = spiperone greater than dopamine, serotonin, (+/-)-propranolol, and naloxone. Imaging studies in a monkey with the resolved isomer, R(+)-[123I]TISCH, demonstrated a high uptake in the basal ganglia and prolonged retention. The preliminary data suggest that R(+)-TISCH is selective for the CNS D1 receptor and is potentially useful for in vivo and in vitro pharmacological studies. When labeled with iodine-123, it may be suitable for noninvasive imaging in humans.