gebhart/patrepeval huggingface dataset:
An Adaptive Postprocessing Technique for the Reduction of Color Bleeding in DCT-Coded Images (2004)

We propose a new postprocessing technique developed specifically for the reduction of color bleeding in DCT-coded color images. The proposed algorithm, based on a complete analysis of this particular kind of distortion, is used to identify and reduce color bleeding artifacts while attempting to preserve the sharpness of the reconstructed images. Simulation results show that the method successfully reduces color bleeding in reconstructed images and improves the visual quality, both objectively and subjectively.
Synthesis of Novel Renewable Polyesters and Polyamides with Olefin Metathesis (2016)

Unsaturated and hydroxyl-functionalized C6-dicarboxylic acids were successfully synthesized via olefin metathesis from methyl vinyl glycolate (MVG), a renewable α-hydroxy C4-ester product from Lewis-acid carbohydrate conversion. Addition of a second-generation Hoveyda–Grubbs catalyst to neat MVG leads to a near quantitative yield of dimethyl-2,5-dihydroxy-3-hexenedioate (DMDHHD). Additional hydrolysis and hydrogenation steps form interesting polymer building blocks like 2,5-dihydroxy-3-hexenedioic acid (DHHDA) and 2,5-dihydroxyadipic acid (DHAA). Their use in polyester and polyamide synthesis is demonstrated after determination of their physical and spectroscopic characteristics. Copolymerization of DHHDA with l-lactic acid for instance produces a cross-linked poly(l-lactic acid-co-DHHDA) polyester. Proof of cross-links is ascertained by NMR and FTIR. Substantial impact on the melting, thermal, and polar properties of PLA are observed already at low amounts of DHHDA (0.1 mol %) in accord with the presence of cross-links in the polymer. Biobased polyamides were also synthesized by equimolar reaction of DHHDA with hexamethylenediamine, producing a renewable polyamide analogue of the petroleum-based nylon-6,6. Interestingly, the as-synthesized polyamide (α-bishydroxylated unsaturated polyamide, HUPA) possesses similar thermal stability as nylon-6,6 but shows different chemical properties as a result of the double bond and α-hydroxy functionality.
Increase in antinociceptive effect of [leu5]enkephalin after intrathecal administration of mixture of three peptidase inhibitors. (2013)

The present data, together with those of earlier studies, clearly demonstrate that amastatin-, captopril-, and phosphoramidon-sensitive enzymes play an important role in the inactivation of [Leu5]enkephalin administered intrathecally in rat.
Effect of a soybean hull:soy lecithin:soapstock mixture on ruminal digestion and performance of growing beef calves and lactating dairy cattle (1993)

Four experiments were conducted to evaluate the effect of a soybean hull, soy lecithin, and soapstock mixture on ruminal fiber and protein digestion, growth efficiency of beef calves, and lactational performance of dairy cattle. An initial mixing experiment determined that a 4:1 ratio (DM basis) of soy lecithin:soapstock could be added to soybean hulls at 15% (wt/wt, DM basis); this mixture had acceptable mixing and handling characteristics. Dietary addition of a mixture of 85% soybean hulls, 12% soy lecithin, and 3% soapstock (DM basis; SLS) to provide 0, 3, 5, or 7% supplemental fat resulted in a linear (P < .01) decrease in in situ rate of ruminal NDF digestion with no effect on rate of CP digestion. Daily gain, DMI, and feed efficiency (kilograms of gain/kilogram of DMI) of growing beef calves were not affected (P > .10) as graded levels of SLS replaced corn grain. However, as graded levels of SLS replaced soybean hulls, daily gain and feed efficiency increased linearly (P < .01). Based on the results of these trials, Holstein dairy cattle were fed four isonitrogenous and isoenergetic diets that contained either high levels of nonfiber carbohydrates (43%) and no added fat, 1% ruminally inert fat, a 6% level of SLS, or a 12% SLS level (all on DM basis). Efficiency of 4% fat-corrected milk production (kilograms of milk/kilogram of DMI) was greatest for cows fed SLS at 6% of dietary DM. The SLS mixture was an excellent source of fiber and vegetable fat, comparable in feeding value to corn grain, for inclusion in the diets of beef calves and dairy cows.
One-Step Exfoliation of Kaolinites and Their Transformation into Nanoscrolls (2011)

Kaolinite nanoscrolls, rolled kaolinite sheets with a tubular form, were prepared by a one-step route in which intercalation of guest species and swelling with solvent proceed at the same time. A methoxy-modified kaolinite was exfoliated by the intercalation of hexadecyltrimethylammonium chloride. The formation of nanoscrolls by the one-step route proceeded only by several alkyltrimethylammonium salts and 1-hexadecyl-3-methylimidazolium chloride. Intercalation of primary amines caused the formation of nanoscrolls by a two-step route in which the intercalation and swelling proceed separately. The successful one-step route is ascribed to the relatively weak interactions between the head groups of guest species and the interlayer surface of methoxy-modified kaolinite, and the interaction is thought to allow the formation of a flexible array of interlayer guest species for swelling. The tubular structure was mostly retained after the heat treatment at 600 °C to form hierarchically porous aluminosilicates with amorphous frameworks. The nanoscrolls intercalated organic guests species, which are not directly intercalated into methoxy-modified kaolinite, between the scrolled layers. The formation route to nanoscrolls is quite dependent not only on the surface modification of kaolinite but also on the structure of guest species.
[Functional status of respiratory muscles and physical endurance among women under prolonged hypokinesia]. (1998)

Validity of the hypothesis for the role of the respiratory muscles in deterioration of physical work capacity following long-term hypokinesia was tested. Experiments were performed with participation of 8 female subjects aged from 27 to 36 years in the 120-day head-down bed rest. Physical performance and functional status of the respiratory muscles have been determined during incremental loading on bicycle ergometer with normal respiration and breathing against additional external resistance. Functional deficit of the respiratory muscles due to long-term bed rest was shown not to allow adequate ventilation and gas exchange at submaximal loads. This resulted in dyspnea, hypoventilation-induced decrease in oxygen consumption and carbon dioxide release, hypercapnia, and lowered threshold of anaerobic metabolism which, in parallel with the deconditioning of the cardiovascular system and the skeletal anti-g musculature, were responsible for degradation of aerobic physical work capacity.
Corticosteroid Decomposition via a Mixed Anhydride (2002)

Oxidation of dexamethasone in an aqueous suspension by air during prolonged storage produces the 17alpha-formyloxy-17beta-carboxylic acid 4. A pathway to 4 is proposed that involves Baeyer-Villiger-type oxidation of keto aldehyde 1 to mixed anhydride 5, followed by intramolecular formyl transfer. Synthetically, acid 3 was reacted with N,N'-carbonyldiimidazole followed by triethylammonium formate in order to generate the transient anhydride 5 en route to an authentic sample of 4.
Late Mesozoic and Early Cenozoic Sediment Cores from the Arctic Ocean (1974)

Research Article| January 01, 1974 Late Mesozoic and Early Cenozoic Sediment Cores from the Arctic Ocean David L. Clark David L. Clark 1Department of Geology and Geophysics, University of Wisconsin, Madison, Wisconsin 53706 Search for other works by this author on: GSW Google Scholar Geology (1974) 2 (1): 41–44. https://doi.org/10.1130/0091-7613(1974)2<41:LMAECS>2.0.CO;2 Article history first online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation David L. Clark; Late Mesozoic and Early Cenozoic Sediment Cores from the Arctic Ocean. Geology 1974;; 2 (1): 41–44. doi: https://doi.org/10.1130/0091-7613(1974)2<41:LMAECS>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract Only two sediment cores taken from ice island T-3 in the Arctic Basin have material older than Pliocene age. One of these cores includes a Late Cretaceous silicoflagellatc assemblage contained in tuffaceous sediment; the other is of Paleocene to Eocene age, containing abundant phytoplankton in tuffaceous sediment. The two cores represent displaced Cretaceous and early Cenozoic masses within a Pliocene-Pleistocene sequence. Both cores were taken from the Alpha Cordillera.These cores provide the first firm evidence that the Arctic Ocean existed at least by Late Cretaceous time, a time during which it had no ice cover and was a much warmer ocean than it is now. Warm water conditions continued at least into Eocene time. No Oligocene or Miocene material has been identified, but, by Pliocene time, the Arctic was ice covered, and this condition has existed until the present. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Identification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts1 (2002)

The increasing polymorphism detected at the MIC loci combined with the results of this study suggest that typing for the MIC loci and crossmatching for the detection of anti-MIC antibodies before transplantation should be used routinely. A better recipient-donor selection based on a negative crossmatch for both anti-donor HLA and MICA antibodies will decrease early graft rejections and losses.
MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i> (2008)

Nonselective inhibitors of human histone deacetylases (HDAC) are known to have antitumor activity in mice in vivo, and several of them are under clinical investigation. The first of these, Vorinostat (SAHA), has been approved for treatment of cutaneous T-cell lymphoma. Questions remain concerning which HDAC isotype(s) are the best to target for anticancer activity and whether increased efficacy and safety will result with an isotype-selective HDAC inhibitor. We have developed an isotype-selective HDAC inhibitor, MGCD0103, which potently targets human HDAC1 but also has inhibitory activity against HDAC2, HDAC3, and HDAC11 in vitro. In intact cells, MGCD0103 inhibited only a fraction of the total HDAC activity and showed long-lasting inhibitory activity even upon drug removal. MGCD0103 induced hyperacetylation of histones, selectively induced apoptosis, and caused cell cycle blockade in various human cancer cell lines in a dose-dependent manner. MGCD0103 exhibited potent and selective antiproliferative activities against a broad spectrum of human cancer cell lines in vitro, and HDAC inhibitory activity was required for these effects. In vivo, MGCD0103 significantly inhibited growth of human tumor xenografts in nude mice in a dose-dependent manner and the antitumor activity correlated with induction of histone acetylation in tumors. Our findings suggest that the isotype-selective HDAC inhibition by MGCD0103 is sufficient for antitumor activity in vivo and that further clinical investigation is warranted.
A lower limb EMG-driven biomechanical model for applications in rehabilitation robotics (2009)

Current changes in aging demographics poses new challenges: people require to keep their quality of life even after circumstances that threatened their movement and function. This increases the demand for new physical rehabilitation facilities that go beyond the traditional patient-therapist, one-to-one rehabilitation sessions. Two promising solutions rely on virtual reality and on the development of autonomous active orthoses, or exoskeletons. Whatever is the chosen approach, there is a requirement for a robust human-machine interface for the control, able to understand patient's intention and to produce an immediate activation of the device. This paper presents a biomechanical model, a possible solution able to predict joint torque from the surface electromyography signals emitted by muscles during their activation. The main objective of the research is to investigate the benefits and efficacy of this model and to lay down the basis of our current research, whose main goal is to make possible a rehabilitation process either with active orthoses or virtual reality. Experiments involving all the steps of our model demonstrate the viability and effectiveness of our approach.
Photo‐assisted peptide enrichment in protein complex cross‐linking analysis of a model homodimeric protein using mass spectrometry (2011)

MS analysis of cross-linked peptides can be used to probe protein contact sites in macromolecular complexes. We have developed a photo-cleavable cross-linker that enhances peptide enrichment, improving the signal-to-noise ratio of the cross-linked peptides in mass spectrometry analysis. This cross-linker utilizes nitro-benzyl alcohol group that can be cleaved by UV irradiation and is stable during the multiple washing steps used for peptide enrichment. The enrichment method utilizes a cross-linker that aids in eliminating contamination resulting from protein-based retrieval systems, and thus, facilitates the identification of cross-linked peptides. Homodimeric pilM protein from Pseudomonas aeruginosa 2192 (pilM) was investigated to test the specificity and experimental conditions. As predicted, the known pair of lysine side chains within 14 Å was cross-linked. An unexpected cross-link involving the protein's amino terminus was also detected. This is consistent with the predicted mobility of the amino terminus that may bring the amino groups within 19 Å of one another in solution. These technical improvements allow this method to be used for investigating protein-protein interactions in complex biological samples.
Enhancing As sup 5+ removal by a Fe sup 2+ -treated activated carbon (1989)

The effectiveness of pretreating an activated carbon with iron-salt solution to improve its arsenic removal capacity was studied. Various factors such as type and concentration of salt, pH, and treating time were thoroughly investigated for their effects on the improvement of removal capacity. An effort was made to identify the optimal pretreatment conditions. A ten-fold increase, over the untreated activated carbon, in removal can be achieved under the optimal pretreatment procedure. The enhancement in removal by treatment occurs by adsorption of ferrous ions and formation of arsenate complexes. Ferrous salts can also be used to regenerate the activated carbon.
Modified dynamic modulus test and customised prediction model of asphalt-treated drainage layer materials for M-E pavement design (2015)

The past two decades have seen great developments and application of asphalt treated open-graded mixtures as a drainage layer in pavement in the United States. Nevertheless, the previous research has also indicated weak mechanical properties of the drainage layer compared with dense-graded asphalt concrete. This study sought to quantify the stiffness of the drainage layer materials for incorporating them into a mechanistic-empirical pavement design framework. It was found in this study that both the current dynamic modulus test method and the empirical prediction model, which were developed for dense-graded asphalt concrete, may not be applicable to drainage layer mixtures with high porosity. Under this circumstance, a modified dynamic modulus test and a calibrated model to predict the dynamic modulus for drainage layer materials have been developed based on the AASHTO TP 342-11 test method and the NCHRP 1-37A model in this study.
ChemInform Abstract: Synthetic Receptors for Anion Complexation (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action (2018)

A new generation of heterobifunctional small molecules, termed proteolysis targeting chimeras (PROTACs), targets proteins for degradation through recruitment to E3 ligases and holds significant therapeutic potential. Despite numerous successful examples, PROTAC small molecule development remains laborious and unpredictable, involving testing compounds for end-point degradation activity at fixed times and concentrations without resolving or optimizing for the important biological steps required for the process. Given the complexity of the ubiquitin proteasomal pathway, technologies that enable real-time characterization of PROTAC efficacy and mechanism of action are critical for accelerating compound development, profiling, and improving guidance of chemical structure-activity relationship. Here, we present an innovative, modular live-cell platform utilizing endogenous tagging technologies and apply it to monitoring PROTAC-mediated degradation of the bromodomain and extra-terminal family members. We show comprehensive real-time degradation and recovery profiles for each target, precisely quantifying degradation rates, maximal levels of degradation ( D<sub>max</sub>), and time frame at D<sub>max</sub>. These degradation metrics show specific PROTAC and family member-dependent responses that are closely associated with the key cellular protein interactions required for the process. Kinetic studies show cellular ternary complex stability influences potency and degradation efficacy. Meanwhile, the level of ubiquitination is highly correlated to degradation rate, indicating ubiquitination stemming from productive ternary complex formation is the main driver of the degradation rate. The approaches applied here highlight the steps at which the choice of E3 ligase handle can elicit different outcomes and discern individual parameters required for degradation, ultimately enabling chemical design strategies and rank ordering of potential therapeutic compounds.
A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete, and Durable Tumor Regression in Mice (2013)

We have designed, synthesized, and evaluated a series of new compounds based upon our previously reported bivalent Smac mimetics. This led to the identification of compound 12 (SM-1200), which binds to XIAP, cIAP1, and cIAP2 with Ki values of 0.5, 3.7, and 5.4 nM, respectively, inhibits cell growth in the MDA-MB-231 breast cancer and SK-OV-3 ovarian cancer cell lines with IC50 values of 11.0 and 28.2 nM, respectively. Compound 12 has a much improved pharmacokinetic profile over our previously reported bivalent Smac mimetics and is highly effective in induction of rapid and durable tumor regression in the MDA-MB-231 xenograft model. These data indicate that compound 12 is a promising Smac mimetic and warrants extensive evaluation as a potential candidate for clinical development.
Simian Virus 40 T Antigen-induced Amplification of Pre-parietal Cells in Transgenic Mice. (1995)

Gastric units in the glandular epithelium of the mouse stomach contain several types of continuously renewing epithelial cells. Acid-producing parietal cells are derived from a multipotent stem cell that also gives rise to mucus-producing pit cells and pepsinogen- and intrinsic factor-producing zymogenic cells. We used nucleotides -1035 to +24 of the mouse H+/K(+)-ATPase beta subunit gene (H+/K(+)-ATPase beta subunit-1035 to +24) to examine the consequences of expressing simian virus 40 T antigen (SV 40 TAg) in the normally rare, nonproliferating, short-lived pre-parietal cell progenitor. Light and electron microscopic morphologic studies plus multilabel immunohistochemical analyses of postnatal day (P) 14-80-day transgenic mice revealed that SV40 TAg produces a 50-70-fold amplification of pre-parietal cells which become the predominant cell type in gastric units. Differentiation to mature parietal cells is blocked, resulting in hypochlorhydria and an associated systemic iron deficiency. SV40 TAg-induced pre-parietal proliferation is accompanied by apoptosis. Examination of adult transgenic mice homozygous for p53 wild type or p53 null alleles established that the apoptosis occurs through a p53-independent pathway. H+/K(+)-ATPase beta subunit -1035 to +24/SV40 Tag is not expressed during differentiation of the zymogenic lineage. Nonetheless, P28-P80 transgenic mice exhibit an apparent block in the conversion of pre-zymogenic to zymogenic cells. This block appears to be quite specific: conversion of preneck to neck cells and neck to pre-zymogenic cells is not affected. Comparison of normal and transgenic mice that are p53+/+ or p53-/- confirmed that the loss of mature zymogenic cells is not dependent upon p53. Although H+/K(+)-ATPase beta subunit -1035 to +24 is not active in pit cell progenitors or their differentiated descendants, there is a 2-3-fold increase in mature pit cells in transgenic animals. Our findings (i) demonstrate an approach for amplifying and characterizing pre-parietal or other progenitor cell populations in gastric units, (ii) reveal an SV40 TAg-inducible, p53-independent apoptotic mechanism that operates in a committed epithelial progenitor cell, and (iii) provide a transgenic mouse model for defining factors that may mediate progression through specific points in the differentiation programs of the parietal and zymogenic cell lineages or that may influence decisions about allocation to the pit cell lineage.
Recessive Ataxia With Ocular Apraxia (2001)

Ataxia with ocular apraxia may be more frequent than postulated before, and may be identified clinically using the following criteria: (1) autosomal recessive transmission; (2) early onset (for most patients in early childhood); (3) combination of cerebellar ataxia, ocular apraxia, and early areflexia, with later appearance of the full picture of peripheral neuropathy; (4) absence of mental retardation, telangiectasia, and immunodeficiency; and (5) the possibility of a long survival, although with severe motor handicap.
Parallel computations on the CHARM heterogeneous workstation cluster (2002)

In recent years parallel computing on a fast network of high performance and low cost workstations has become a viable and an economic option, compared to that on an expensive high performance parallel supercomputer for solving large Grand Challenge scientific problems. This paper focuses on how to efficiently exploit the computing resources of a set of heterogeneous Unix workstations. We have further developed the CHARM parallel programming environment to allow programs written in the CHARM language execute adjacently on such a cluster. We have also developed a new scheme to schedule tasks statically and balance the load dynamically to achieve high effective utilization. Performance results for several applications programs including ray-tracing, all-pairs shortest path, and matrix multiply on a heterogeneous cluster of Sun Sparcs, IBM RS/6000s and HP-PA 7100s show a significant improvement in execution time over sequential execution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>