gebhart/patrepeval huggingface dataset:
A compact representation of graph databases (2010)

Graph databases have emerged as an alternative data model with applications in many complex domains. Typically, the problems to be solved in such domains involve managing and mining huge graphs. The need for efficient processing in such applications has motivated the development of methods for graph compression and indexing. However, most methods aim at an efficient representation and processing of simple graphs (without attributes in nodes or edges, or multiple edges for a given pair of nodes). In this paper we present a model for compact representation of general graph databases. It represents an attractive alternative due to the compression rates it achieves and its efficient navigation operations.
Molecular genetic analysis of cold–regulated gene transcription (2002)

Chilling and freezing temperatures adversely affect the productivity and quality of crops. Hence improving the cold hardiness of crop plants is an important goal in agriculture, which demands a clear understanding of cold stress signal perception and transduction. Pharmacological and biochemical evidence shows that membrane rigidification followed by cytoskeleton rearrangement, Ca(2+) influx and Ca(2+)-dependent phosphorylation are involved in cold stress signal transduction. Cold-responsive genes are regulated through C-repeat/dehydration-responsive elements (CRT/DRE) and abscisic acid (ABA)-responsive element cis elements by transacting factors C-repeat binding factors/dehydration-responsive element binding proteins (CBFs/DREBs) and basic leucine zippers (bZIPs) (SGBF1), respectively. We have carried out a forward genetic analysis using chemically mutagenized Arabidopsis plants expressing cold-responsive RD29A promoter-driven luciferase to dissect cold signal transduction. We have isolated the fiery1 (fry1) mutant and cloned the FRY1 gene, which encodes an inositol polyphosphate 1-phosphatase. The fry1 plants showed enhanced induction of stress genes in response to cold, ABA, salt and dehydration due to higher accumulation of the second messenger, inositol (1,4,5)- triphosphate (IP(3)). Thus our study provides genetic evidence suggesting that cold signal is transduced through changes in IP(3) levels. We have also identified the hos1 mutation, which showed super induction of cold-responsive genes and their transcriptional activators. Molecular cloning and characterization revealed that HOS1 encodes a ring finger protein, which has been implicated as an E3 ubiquitin conjugating enzyme. HOS1 is present in the cytoplasm at normal growth temperatures but accumulates in the nucleus upon cold stress. HOS1 appears to regulate temperature sensing by the cell as cold-responsive gene expression occurs in the hos1 mutant at relatively warm temperatures. Thus HOS1 is a negative regulator, which may be functionally linked to cellular thermosensors to modulate cold-responsive gene transcription.
Methadyl Acetate and Methadone as Maintenance Treatments for Heroin Addicts (1976)

This was a double-blind comparison of methadyl acetate and two dose levels of methadone hydrochloride in the maintenance of 430 street heroin addicts from 12 Veterans Administration hospitals. The starting sample consisted of 146 patients receiving low-dose methadone, 142 patients receiving methadyl acetate. Patients were first given 30 mg of both drugs, and doses were incremented by 10 mg/week until they stabilized at methadyl acetate, 80 mg three times a week, and methadone hydrochloride, 50 mg daily or 100 mg daily. Dosage was fixed for the balance of the 40-week treatment period. Safety was evaluated by clinical and laboratory observations conducted at frequent intervals throughout the study. Relative efficacy was evaluated by illicit drug use, program retention and attendance, and global staff judgments. It is concluded that methadyl acetate is as safe a drug as methadone and that it compares favorably with highdose methoadone in terms of efficacy. Both methyadyl acetate and high-dose methadone appear to be better maintenance regimens than low-dose methadone under the conditions of this study.
Directing the Heterologous Production of Specific Cyanobacterial Toxin Variants (2017)

Microcystins are globally the most commonly occurring freshwater cyanotoxins, causing acute poisoning and chronically inducing hepatocellular carcinoma. However, the detection and toxicological study of microcystins is hampered by the limited availability and high cost of pure toxin standards. Biosynthesis of microcystin variants in a fast-growing heterologous host offers a promising method of achieving reliable and economically viable alternative to isolating toxin from slow-growing cyanobacterial cultures. Here, we report the heterologous expression of recombinant microcystin synthetases in Escherichia coli to produce [d-Asp<sup>3</sup>]microcystin-LR and microcystin-LR. We assembled a 55 kb hybrid polyketide synthase/nonribosomal peptide synthetase gene cluster from Microcystis aeruginosa PCC 7806 using Red/ET recombineering and replaced the native promoters with an inducible Ptet<sub>O</sub> promoter to yield microcystin titers superior to M. aeruginosa. The expression platform described herein can be tailored to heterologously produce a wide variety of microcystin variants, and potentially other cyanobacterial natural products of commercial relevance.
FPGA Implementation of the Power Electronic Converter Model for Real-Time Simulation of Electromagnetic Transients (2009)

This paper presents an enhanced implementation methodology for the associated discrete circuit model of a power-electronic converter in a field-programmable gate array-based real-time power systems simulator. The simulator is intended for the testing and performance evaluation of digital control/protection platforms based on the hardware-in-the-loop concept. The salient features of the proposed implementation are: 1) It eliminates the need for corrective measures to reduce error due to the lack of synchronization between the simulation time-grid and output signals of the control/protection platform; 2) it provides scalability, that is, it maintains calculation time, within each simulation time step, nearly fixed irrespective of the system size; and 3) it enables the use of a small simulation timestep, for example, a couple of hundreds of nanoseconds for the overall system, in contrast to the microseconds range time-steps used in the existing simulators. Thus, it is also able to provide a wide frequency bandwidth for the simulation results. This paper also reports the implementation results and their verifications corresponding to real-time simulation of two converter units based on less than 60-ns calculation time within each simulation time step. The scalability property is also verified based on real-time simulation of six converter units.
Fundamental study of evaporation model in micron pore (2004)

As the demand for high performance small electronic devices has increased, heat removal\nfrom these devices for space use is approaching critical limits. A heat pipe is a promising\ndevice to enhance the heat removal performance due to the phase change phenomena for\nspace thermal management system. Even though a heat pipe has a big potential to remove\nthe thermal energy from a high heat flux source, the heat removal performance of heat\npipes cannot be predicted well since the first principle of evaporation has not been\nestablished. The purpose of this study is to establish a method to apply the evaporation\nmodel based on the statistical rate theory for engineering application including\nvapor-liquid-structure intermolecular effect. The evaporation model is applied to the heat\npipe performance analysis through a pressure balance and an energy balance in the loop\nheat pipe.
Tree-Net, a multi-level fiber optics MAN (2003)

A novel fiber-optic architecture, Tree-Net, is presented which does not require intermediate processing components. Tree-Net is based on a tree topology, passive station taps, and implicit token protocol. The properties and performance of Tree-Net are evaluated, and possible extensions of the basic scheme are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cluster-Based Spatiotemporal Background Traffic Generation for Network Simulation (2014)

To reduce the computational complexity of large-scale network simulation, one needs to distinguish foreground traffic generated by the target applications one intends to study from background traffic that represents the bulk of the network traffic generated by other applications. Background traffic competes with foreground traffic for network resources and consequently plays an important role in determining the behavior of network applications. Existing background traffic models either operate only at coarse time granularity or focus only on individual links. There is little insight on how to meaningfully apply realistic background traffic over the entire network. In this article, we propose a method for generating background traffic with spatial and temporal characteristics observed from real traffic traces. We apply data clustering techniques to describe the behavior of end hosts as a function of multidimensional attributes and group them into distinct classes, and then map the classes to simulated routers so that we can generate traffic in accordance with the cluster-level statistics. The proposed traffic generator makes no assumption on the target network topology. It is also capable of scaling the generated traffic so that the traffic intensity can be varied accordingly in order to test applications under different and yet realistic network conditions. Experiments show that our method is able to generate traffic that maintains the same spatial and temporal characteristics as in the observed traffic traces.
Impact of the U.S. National Building Information Model Standard (NBIMS) on Building Energy Performance Simulation (2007)

The U.S
Identification of a tumour associated antigen in lung cancer patients with asbestos exposure. (2010)

The antibody titer against AnxA2 may be a potentially useful new diagnostic surrogate marker for asbestos-related lung cancer and malignant mesothelioma.
Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease (2001)

Small GTPases of the Rab family regulate membrane transport pathways. More than 50 mammalian Rab proteins are known, many with transport step-specific localisation. Rabs must associate with cellular membranes for activity and membrane attachment is mediated by prenyl (geranylgeranyl) post-translational modification. Mutations in genes encoding proteins essential for the geranylgeranylation reaction, Rab escort protein and Rab geranylgeranyl transferase, underlie genetic diseases. Choroideremia patients have loss of function mutations in REP1 and the murine Hermansky-Pudlak syndrome model gunmetal possesses a splice-site mutation in the alpha-subunit of RGGT. Here we discuss recent insights into Rab prenylation and advances towards our understanding of both diseases.
Traumatically injured astrocytes release a proteomic signature modulated by <scp>STAT</scp>3‐dependent cell survival (2015)

Molecular markers associated with CNS injury are of diagnostic interest. Mechanical trauma generates cellular deformation associated with membrane permeability with unknown molecular consequences. We used an in vitro model of stretch-injury and proteomic analyses to determine protein changes in murine astrocytes and their surrounding fluids. Abrupt pressure-pulse stretching resulted in the rapid release of 59 astrocytic proteins with profiles reflecting cell injury and cell death, i.e., mechanoporation and cell lysis. This acute trauma-release proteome was overrepresented with metabolic proteins compared with the uninjured cellular proteome, bearing relevance for post-traumatic metabolic depression. Astrocyte-specific deletion of signal transducer and activator of transcription 3 (STAT3-CKO) resulted in reduced stretch-injury tolerance, elevated necrosis and increased protein release. Consistent with more lysed cells, more protein complexes, nuclear and transport proteins were released from STAT3-CKO versus nontransgenic astrocytes. STAT3-CKO astrocytes had reduced basal expression of GFAP, lactate dehydrogenase B (LDHB), aldolase C (ALDOC), and astrocytic phosphoprotein 15 (PEA15), and elevated levels of tropomyosin (TPM4) and α actinin 4 (ACTN4). Stretching caused STAT3-dependent cellular depletion of PEA15 and GFAP, and its filament disassembly in subpopulations of injured astrocytes. PEA15 and ALDOC signals were low in injured astrocytes acutely after mouse spinal cord crush injury and were robustly expressed in reactive astrocytes 1 day postinjury. In contrast, α crystallin (CRYAB) was present in acutely injured astrocytes, and absent from uninjured and reactive astrocytes, demonstrating novel marker differences among postinjury astrocytes. These findings reveal a proteomic signature of traumatically-injured astrocytes reflecting STAT3-dependent cellular survival with potential diagnostic value.
Characterizing parallel workloads to reduce multiple writer overhead in shared virtual memory systems (2003)

Shared virtual memory (SVM) systems, because of their software implementation, enable shared-memory programming at a low design and maintenance cost. Nevertheless, as hardware implementations become faster, their performance is still far from that achieved by distributed shared memory (DSM) systems. Nowadays, SVM systems use relaxed memory consistency models and multiple writer protocols as techniques to reduce latencies and false sharing, respectively. However, these techniques induce additional overhead that decreases system performance. We performed a study of workload behavior aimed at improving the design of SVM protocols. The work focused on the identification of the type of shared data patterns that can appear in the accesses to protected sections using semaphores. Most coherence actions in SVM systems are performed as a consequence of the write operations executed in critical sections, so we pay special attention to the write operations performed when multiple writers are allowed. As these write operations may present spatial locality, we also study the write patterns on shared pages with similar behaviour. Different software filters are applied in the instrumented parallel workloads selected to capture and classify the most common sharing patterns. This enables the recognition of those patterns in which coherence overhead can be reduced by modifying the coherence actions performed by the protocol. Despite the fact that the performance evaluation of new coherence solutions is not our main goal, the ideas presented to improve the behaviour of SVM systems can be implemented at a reasonable hardware/software cost.
An Encoder-Decoder Framework Translating Natural Language to Database Queries (2018)

Machine translation is going through a radical revolution, driven by the explosive development of deep learning techniques using Convolutional Neural Network (CNN) and Recurrent Neural Network (RNN). In this paper, we consider a special case in machine translation problems, targeting to convert natural language into Structured Query Language (SQL) for data retrieval over relational database. Although generic CNN and RNN learn the grammar structure of SQL when trained with sufficient samples, the accuracy and training efficiency of the model could be dramatically improved, when the translation model is deeply integrated with the grammar rules of SQL. We present a new encoder-decoder framework, with a suite of new approaches, including new semantic features fed into the encoder, grammar-aware states injected into the memory of decoder, as well as recursive state management for sub-queries. These techniques help the neural network better focus on understanding semantics of operations in natural language and save the efforts on SQL grammar learning. The empirical evaluation on real world database and queries show that our approach outperform state-of-the-art solution by a significant margin.
Self‐sufficient minority carrier lifetime in silicon from quasi‐steady‐state photoluminescence (2012)

Abstract Quasi‐steady‐state photoluminescence is a versatile technique to determine carrier lifetime in silicon. A recent approach extracts carrier lifetime without a priori information about dopant concentration [Appl. Phys. Lett. 97 , 092109 (2010)]. It utilizes the phase shift between a time‐modulated optical irradiation and the radiative recombination of a sample, while requiring a minimum of two measurements. The present paper is aimed at a generalization thereof that requires only one measurement. It brings about a substantial experimental simplification, significantly improved accuracy and precision, and it opens up paths to access material properties other than lifetime.
Chance Factors in Nonparametric Linear Discriminant Studies (1986)

Abstract Studies were performed to determine if the screening of large pools of prospective variables could lead to fortuitous improvements in the classification success rates provided by nonparametric linear discriminants. These studies parallel earlier work by Topliss and Edwards on regression analysis. It was found that fortuitous increases do occur, but could probably be kept low if the number of examined variables is kept below one‐half the number of observations.
Visual and auditory attentional capture are both sluggish in children with developmental dyslexia (2005)

Automatic multimodal spatial attention was studied in 12 dyslexic children (SRD), 18 chronological age matched (CA) and 9 reading level matched (RL) normally reading children by measuring reaction times (RTs) to lateralized visual and auditory stimuli in cued detection tasks. The results show a slower time course of focused multimodal attention (FMA) in SRD children than in both CA and RL controls. Specifically, no cueing effect (i.e., RTs difference between cued-uncued) was found in SRD children at 100 ms cue-target delay, while it was present at 250 ms cue-target delay. In contrast, in both CA and RL controls, a cueing effect was found at the shorter cue-target delay but it disappeared at the longer cue-target delay, as predicted by theories of automatic capture of attention. Our results suggest that FMA may be crucial for learning to read, and we propose a possible causal explanation of how a FMA deficit leads to specific reading disability, suggesting that sluggish FMA in dyslexic children could be caused by a specific parietal dysfunction.
Ultrasonically induced microtransport (2002)

Fluid motion induced by traveling flexural waves in 4 mu m thick membranes was observed using 2.5 mu m diameter polystyrene spheres in water to make the fluid motion visible. Visual observation of the spheres indicates that they move in the direction of wave propagation with a speed proportional to the square of the acoustic amplitude. The maximum speed is 130 mu m/s for an RF drive voltage of 7.1 Vrms at 3.5 MHz; the wavelength is 100 mu m. Standing Lamb waves, which can be seen visually with a phase-contrast microscope, are found to trap particles, including bacteria located in a drop of water that contacts the membrane. A first order model of Lamb-wave micropumping is presented, based on acoustic streaming theory. Important parameters for device design and operation are discussed, along with options for integrating the device into microflow systems. Possible applications include temperature redistribution in ICs and miniature chemical processing systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multi-stratum Resource Integration for OpenFlow-Based Data Center Interconnect [Invited] (2013)

Nowadays, most service providers offer their services and support their applications through federated sets of data centers that need to be interconnected using high-capacity telecom transport networks. To provide such high-capacity network channels, data center interconnection is typically based on IP and optical transport networks that ensure certain end-to-end connectivity performance guarantees. However, in the current mode of operation, the control of IP networks, optical networks, and data centers is separately deployed. Enabling even a limited interworking among these separated control systems requires the adoption of complex and inelastic interfaces among the various networks, and this solution is not efficient enough to provide the required quality of service. In this paper, we propose a multi-stratum resource integration (MSRI) architecture for OpenFlow-based data center interconnection using IP and optical transport networks. The control of the architecture is implemented through multiple OpenFlow controllers’ cooperation. By exchanging information among multiple controllers, the MSRI can effectively overcome the interworking limitations of a multi-stratum architecture, enable joint optimization of data center and network resources, and enhance the data center responsiveness to end-to-end service demands. Additionally, a service-aware flow estimation strategy for MSRI is introduced based on the proposed architecture. The overall feasibility and efficiency of the proposed architecture are experimentally demonstrated on our optical as a service testbed in terms of blocking probability, resource occupation rate, and path provisioning latency.
Shape effects of cuprous oxide particles on stability in water and photocatalytic water splitting (2014)

The stability of different shapes of cuprous oxides was tested in deionized water with or without light irradiation. The morphology was degraded by the formation of CuO at the surface differently with each shape. TiIrO<sub>x</sub>-coated Cu<sub>2</sub>O particles presented improved stability for overall water splitting producing hydrogen and oxygen.
Load, stress, and recovery in adolescent rugby union players during a competitive season (2009)

Despite increased professionalization of adolescent sport and improved articulation to elite adult participation, the impact of sports such as rugby union among adolescents is under-explored. This study describes psychological stress-recovery responses relative to training loads in 106 male adolescent rugby union players. The results showed that players with the highest training and physical activity volumes during the season demonstrated more favourable recovery-stress states than moderate- and low-volume groups. Stress and under-recovery did not increase with increases in weekly volume when assessed across a season. When assessed more acutely during intensive competition phases, stress and under-recovery increased with increases in participation demands. Despite better psychological stress and recovery profiles of more elite, higher-load players, not all participants demonstrated favourable capacities to deal with stress and recovery processes. Seven participants were in at least two of three categories of highest volume, highest stress, and poorest recovery. Even in the absence of a full understanding of the impact of high-volume, high-stress, poor-recovery participation among adolescent athletes, these markers may be precursors for more deleterious outcomes such as injury, performance decrements, and overtraining. Findings support the efficacy of serially monitoring young athletes.
ChemInform Abstract: REACTION OF HYDROXY AND CARBONYL COMPOUNDS WITH SULFUR TETRAFLUORIDE. XII. REACTIONS OF ESTERS OF ALIPHATIC α‐ AND β‐HYDROXY CARBOXYLIC ACIDS WITH SULFUR TETRAFLUORIDE (1984)

Abstract Die α‐Hydroxyester (I) reagieren mit SF 4 an der OH‐ Gruppe unter HF‐Eliminierung.