gebhart/patrepeval huggingface dataset:
Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort (2016)

Purpose Treatment with pembrolizumab, an anti-programmed death-1 antibody, at 10 mg/kg administered once every 2 weeks, displayed durable antitumor activity in programmed death-ligand 1 (PD-L1) -positive recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) in the KEYNOTE-012 trial. Results from the expansion cohort, in which patients with HNSCC, irrespective of biomarker status, received a fixed dose of pembrolizumab at a less frequent dosing schedule, are reported. Patients and Methods Patients with R/M HNSCC, irrespective of PD-L1 or human papillomavirus status, received pembrolizumab 200 mg intravenously once every 3 weeks. Imaging was performed every 8 weeks. Primary end points were overall response rate (ORR) per central imaging vendor (Response Evaluation Criteria in Solid Tumors v1.1) and safety. Secondary end points included progression-free survival, overall survival, and association of response and PD-L1 expression. Patients who received one or more doses of pembrolizumab were included in analyses. Results Of 132 patients enrolled, median age was 60 years (range, 25 to 84 years), 83% were male, and 57% received two or more lines of therapy for R/M disease. ORR was 18% (95% CI, 12 to 26) by central imaging vendor and 20% (95% CI, 13 to 28) by investigator review. Median duration of response was not reached (range, ≥ 2 to ≥ 11 months). Six-month progression-free survival and overall survival rates were 23% and 59%, respectively. By using tumor and immune cells, a statistically significant increase in ORR was observed for PD-L1-positive versus -negative patients (22% v 4%; P = .021). Treatment-related adverse events of any grade and grade ≥ 3 events occurred in 62% and 9% of patients, respectively. Conclusion Fixed-dose pembrolizumab 200 mg administered once every 3 weeks was well tolerated and yielded a clinically meaningful ORR with evidence of durable responses, which supports further development of this regimen in patients with advanced HNSCC.
Thermal decontamination of railway sleepers for recycling. Removal of creosote oil (2010)

Because of the high content of PAHs (polyphenolic aromatic hydrocarbons) in wooden railway sleepers, legislative regulations require the thermal combustion of the sleepers after removal from the track bed or permit an altemate usage only in a limited frame. Decontamination experiments were performed by means of temperature and reduced pressure in technical scale, aiming on the removal of the PAHs from used railway sleepers in order to provide alternative ways for recycling of the wood tissue. Both railway sleepers as well as uniform laboratory samples were treated, and subsequently investigated by liquid extraction and liquid injection gas chromatography-mass spectrometry (GC-MS). The decontamination treatment at a temperature of 220Â°C removes up to 75% of PAHs, main active substances of the creosote oils. For complete PAHs removal, process parameters need to be further improved.
Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases (2011)

Comparison of the human and parasite GSK-3 ATP binding site models has shown that the development of selective drugs affecting parasite GSK-3 is possible. Known inhibitors of human GSK-3 can also be used as starting scaffolds for the search for drugs acting against parasitic diseases.
A simple coma corrector for off-axis guiding (1980)

An adjustable coma and astigmatism corrector, using two small simple lenses, and suitable for correcting the image of an off-axis guide star up to about 1° from the axis of a paraboloidal reflector, is described. The on-axis image is not obscured, and retains its seeing-limited quality, achromatism and high efficiency.
Streaming Link Prediction on Dynamic Attributed Networks (2018)

Link prediction targets to predict the future node interactions mainly based on the current network snapshot. It is a key step in understanding the formation and evolution of the underlying networks; and has practical implications in many real-world applications, ranging from friendship recommendation, click through prediction to targeted advertising. Most existing efforts are devoted to plain networks and assume the availability of network structure in memory before link prediction takes place. However, this assumption is untenable as many real-world networks are affiliated with rich node attributes, and often, the network structure and node attributes are both dynamically evolving at an unprecedented rate. Even though recent studies show that node attributes have an added value to network structure for accurate link prediction, it still remains a daunting task to support link prediction in an online fashion on such dynamic attributed networks. As changes in the dynamic attributed networks are often transient and can be endless, link prediction algorithms need to be efficient by making only one pass of the data with limited memory overhead. To tackle these challenges, we study a novel problem of streaming link prediction on dynamic attributed networks and present a novel framework - SLIDE. Methodologically, SLIDE maintains and updates a low-rank sketching matrix to summarize all observed data, and we further leverage the sketching matrix to infer missing links on the fly. The whole procedure is theoretically guaranteed, and empirical experiments on real-world dynamic attributed networks validate the effectiveness and efficiency of the proposed framework.
A new definition (2000)

Gore Vidal told a wonderful joke on the radio recently about the former British prime minister Harold Macmillan and a social visit he paid with his wife to the then French president, Charles de Gaulle. At the end of a long and probably very boring meal, Macmillan turned to Madame de Gaulle and asked politely what she was looking forward …
Symbol-Wavelength MMSE Gain in a Multi-Antenna UWB System (2006)

Ultra wideband (UWB) technology has the potential to provide high speed data services. These speeds can be greatly increased by using multiple input multiple output (MIMO) techniques. Multiple antennas are used to achieve spatial diversity and these antenna elements must be separated properly to have uncorrelated communication signals. The separation can be on the scale of a symbol wavelength ([speed of light]/[symbol rate]). We have designed a printed circular disc monopole and measured the UWB radio channel. Finally, we used the measurements to show the minimum mean squared error (MMSE) performance gain which occurs when the receiver antennas are separated on the scale of a symbol wavelength.
Modeling cyanide release from nitriles: prediction of cytochrome P 450-mediated acute nitrile toxicity (1992)

A mechanism-based model for prediction of acute nitrile toxicity was developed using octanol-water partition coefficients (log P) and estimated rates of alpha-hydrogen atom abstraction as variables. Relative rates of hydrogen atom abstraction were derived from differences in heats of formation for ground-state and radical geometries and radical ionization potentials. Calculated energies of activation for all potential sites of oxidation for a given nitrile were used to estimate partitioning of metabolites among multiple oxidative pathways. logP and the resulting corrected rate constants for alpha-carbon oxidation were effective variables in an acute toxicity model of structurally diverse nitriles. The pharmacokinetics of substrate disposition is discussed in the context of multiple metabolic pathways. Structure-toxicity relationships are also discussed.
A DevOps Approach for Cyber-Physical System-of-Systems Engineering through Arrowhead (2021)

The stakeholders in the Cyber-Physical System-of-Systems (CPS, SoS, CPSoS) domains need to adopt current methodologies that enable reliable but also flexible and timely completion of development, integration, deployment, operation, and even maintenance-related tasks. The so-called DevOps (Development & Operations) approach has been proven in various other domains of IT-related service completion and operation. Both the technology set and the management approaches of CPS and SoS practitioners can benefit the adoption of the DevOps toolchain success stories – the everyday life of software, cloud and IT-service development, and operations-focused companies. This paper proposes an expansion of the application area of the DevOps models, toolchains, and even utilities to the CPS and SoS domains. It proposes to create an abstraction of CPS devices as reusable infrastructure resources, which can be then automatically re-purposed for new workflow tasks, as well as to fill the remaining DevOps tooling gaps with actual Systems of the Arrowhead Framework.
Development and Evaluation of a Cellular Phone Based Teen Driver Support System. (2009)

Motor vehicle crashes are the leading cause of death for teenagers with speeding, seat belt non-compliance, alcohol involvement, and distractions serving as the primary contributors to this unacceptably high crash rate. In an effort to mitigate this situation, a prototype teen driver support system (TDSS) has been designed and developed. This computer-based system provides real-time feedback to teens regarding speed limit violations and warns of upcoming speed zone changes. A unique feature of this system is that speed limit feedback is relative to the speed limit posted on the roadway on which the teen is driving. By informing teens of speeding behavior, it is hoped that this system will reduce teen crash rates. This project includes a description of the TDSS features and specifications for how the TDSS operates using the Smart Phone technology. A small usability study was completed as part of the project where teen drivers (aged 18-19) drove with and without the system. Overall, the pilot study demonstrated that the TDSS could operate effectively within a vehicle driven by a teen driver. Warnings and messages were presented to the drivers and corresponding text messages were sent when drivers failed to alter their behavior in relation to a warning. The performance data trended in the direction expected, with the TDSS encouraging lower speeds and less speeding overall. The teen participants reported that very little mental effort was required to interact with the TDSS while driving, but they also reported the system increased their perceptions of stress while driving. The second phase of the study proposed the information that should be presented in the real-time text messages and to parents in a weekly report. A potential weekly report format is described. Finally, the project identified the issues associated with using the TDSS as an additional tool to support GDL programs.
Complete Genomic Sequence of the <i>O</i> -Desmethylangolensin-Producing Bacterium Clostridium rRNA Cluster XIVa Strain SY8519, Isolated from Adult Human Intestine (2011)

The O-desmethylangolensin-producing Clostridium rRNA cluster XIVa strain SY8519 was isolated from the intestinal flora of a healthy human as a key isoflavonoid-metabolizing bacterium. Here, we report the finished and annotated genomic sequence of this organism.
Foam Generation in Porous Media (2002)

Abstract In steady gas-liquid flow in homogeneous porous media with surfactant present, there is often observed a critical injection velocity or pressure gradient ∇pmin at which "weak" or "coarse" foam is abruptly converted into "strong foam," with a reduction of one to two orders of magnitude in total mobility: i.e., "foam generation." Earlier research on foam generation is extended here with extensive data for a variety of porous media, permeabilities, gases (N2 and CO2), surfactants, and temperatures. For bead- and sandpacks, ∇pmin scales like (1/k), where k is permeability, over 2 ½ orders of magnitude in k; for consolidated media, the relation is more complex. For dense-CO2 foam, ∇pmin exists but can be less than 1 psi/ft. If pressure drop, rather than flow rates, is fixed, one observes an unstable regime between stable "strong" and "coarse" foam regimes; in the unstable regime ∇p is nonuniform in space or variable in time. Results are interpreted in terms of the theory of foam mobilization at a critical pressure gradient.
Silylating Agents (2006)

Abstract Silylating agents are used to replace active hydrogens from the surface of organic materials by trisubstituted silyl groups. This procedure is effected for a variety of reasons. Simple organic compounds may be silylated for purposes of synthesis and analysis; inorganic mineral surfaces may be silylated for purposes of analysis, adhesion, and water repellence; metal oxides, glass, resins, enzymes, etc, may be silylated to effect corrosion resistance, antimicrobial activity, immobilization for catalysis, chromatography column material, waterproofing, etc. The various compounds and the methods utilized for silylation are discussed.
Variable structure control of shape memory alloy actuators (1997)

A shape memory alloy (SMA) actuator consisting of a number of thin NiTi fibers woven in a counter rotating helical pattern around supporting disks is first described. This structure accomplishes a highly efficient transformation between force and displacement overcoming the main mechanical drawback of shape memory alloys, that being limited strain. Time domain open loop experiments were then conducted to determine the intrinsic properties of the actuator. From these experiments and from the knowledge of the underlying physics of SMAs, a multiterm model, including linear and nonlinear elements, was proposed. After further investigation and simulation, it was found that most of these complexities did not need to be considered in order to explain the reported results, and that the model could be reduced to that of a single integrator. A variable structure controller was then applied to a pair of antagonist actuators. The feedback switches between the two actuators according to the sign of the displacement error. A further improvement was added to compensate for known gross nonlinearities by modulating the current magnitude in a discrete manner as a function of the state space position. It was therefore possible to realize smooth and robust control with very little cost in complexity.
Multilevel memory based on molecular devices (2004)

Multilevel molecular memory devices were proposed and demonstrated for nonvolatile data storage up to three bits (eight levels) per cell, in contrast to the standard one-bit-per-cell (two levels) technology. In the demonstration, charges were precisely placed at up to eight discrete levels in redox active molecules self-assembled on single-crystal semiconducting nanowire field-effect transistors. Gate voltage pulses and current sensing were used for writing and reading operations, respectively. Charge storage stability was tested up to retention of 600 h, as compared to the longest retention of a few hours previously reported for one-bit-per-cell molecular memories.
Imatinib-resistant chronic myeloid leukemia (CML): Current concepts on pathogenesis and new emerging pharmacologic approaches. (2007)

Chronic myeloid leukemia (CML) is a stem cell disease, in which the BCR/ABL oncoprotein is considered essential for abnormal growth and accumulation of neoplastic cells. During the past 10 years, the BCR/ABL tyrosine kinase inhibitor imatinib (STI571) has successfully been introduced in the treatment of the disease. However, intrinsic as well as acquired resistance against the drug have been described and have been recognized as an emerging problem and challenge in clinical practice, and a key issue in CML research. Most of the respective concepts focus on imatinib-resistant mutants of BCR/ABL that are detectable in a high proportion of cases. However, other factors also contribute to resistance against imatinib, including the genetic background, the biologic features of CML stem cells, gene amplifications, silencing of tumor suppressor genes, and various pharmacologic aspects. In this article, the mechanisms of resistance against imatinib and other BCR/ABL tyrosine kinase inhibitors in CML are discussed together with strategies to overcome and to prevent resistance with available drugs or with novel antileukemic approaches.
A Quantitative Dot Blot Assay for AAV Titration and Its Use for Functional Assessment of the Adeno-associated Virus Assembly-activating Proteins (2018)

While adeno-associated virus (AAV) is widely accepted as an attractive vector for gene therapy, it also serves as a model virus for understanding virus biology. In the latter respect, the recent discovery of a non-structural AAV protein, termed assembly-activating protein (AAP), has shed new light on the processes involved in assembly of the viral capsid VP proteins into a capsid. Although many AAV serotypes require AAP for assembly, we have recently reported that AAV4, 5, and 11 are exceptions to this rule. Furthermore, we demonstrated that AAPs and assembled capsids of different serotypes localize to different subcellular compartments. This unexpected heterogeneity in the biological properties and functional roles of AAPs among different AAV serotypes underscores the importance of studies on AAPs derived from diverse serotypes. This manuscript details a straightforward dot blot assay for AAV quantitation and its application to assess AAP dependency and serotype specificity in capsid assembly. To demonstrate the utility of this dot blot assay, we set out to characterize capsid assembly and AAP dependency of Snake AAV, a previously uncharacterized reptile AAV, as well as AAV5 and AAV9, which have previously been shown to be AAP-independent and AAP-dependent serotypes, respectively. The assay revealed that Snake AAV capsid assembly requires Snake AAP and cannot be promoted by AAPs from AAV5 and AAV9. The assay also showed that, unlike many of the common serotype AAPs that promote heterologous capsid assembly by cross-complementation, Snake AAP does not promote assembly of AAV9 capsids. In addition, we show that the choice of nuclease significantly affects the readout of the dot blot assay, and thus, choosing an optimal enzyme is critical for successful assessment of AAV titers.
Interference of benzo[a]pyrene diol epoxide‐deoxyguanosine adducts in a GC box with binding of the transcription factor Sp1 (1996)

Previous studies indicated that DNA adducts formed by the carcinogenic diol epoxide 7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) can increase the affinity of the transcription factor Sp1 for DNA sequences that are not normally specific binding sites. Whether adducts that form in the normal binding site, the GC box sequence, increase the affinity of Sp1 for the modified GC-box was not determined. Starting with a 23-nt sequence that contains two natural GC box sequences, site-specifically modified oligonucleotides were prepared with a single (+)-BPDE-deoxyguanosine adduct at one of three positions: the center of each GC-box or in between the two boxes. Four modified oligonucleotides were studied, two derived from cis addition of BPDE to the exocyclic amino group and two from trans addition. For three of these site-specifically modified oligonucleotides, there was a diminution in Sp1 affinity, whereas Sp1 binding to the fourth modified oligonucleotide was abolished. Furthermore, random modification of the oligonucleotide to a level of about 1 BPDE adduct per fragment slightly decreased the affinity for Sp1, and no evidence was found for a subpopulation of molecules with high affinity. These findings suggest that BPDE modification of the GC box does not lead to an increased affinity for Sp1. This is consistent with a model in which a BPDE-induced bend in the DNA mimics the conformation of the normal GC box:Sp1 complex, leading to high-affinity binding of Sp1 to non-GC box sites. © 1996 Wiley-Liss, Inc.
Direct aerobic α,β-dehydrogenation of aldehydes and ketones with a Pd(TFA)<sub>2</sub>/4,5-diazafluorenone catalyst (2011)

The direct α, β-dehydrogenation of aldehydes and ketones represents an efficient alternative to stepwise methods to prepare enal and enone products. Here, we describe a new Pd(TFA)(2)/4,5-diazafluorenone dehydrogenation catalyst that overcomes key limitations of previous catalyst systems. The scope includes successful reactivity with pharmaceutically important cyclopentanone and flavanone substrates, as well as acyclic ketones. Preliminary mechanistic studies compare the reactivity of this catalyst to previously reported dehydrogenation catalysts and reveal that cleavage of the α-C-H bond of the ketone is the turnover-limiting step of the catalytic mechanism.
An Ethic of Abolition (2023)

This paper addresses the uncanny resemblance between the educational industrial complex and the US carceral state. Both schools and prisons comprise carceral apparatuses that use policies, pedagogies, and practices to respond punitively to com­munal transgressions. Moreover, architectural designs and fiscal budgets further reveal symmetries that make learning communities unsafe and complicit with carceral systems. Black and Brown people are disproportionately caught in the frays of punitive disparities, targeted violence, and stereotypes of deviance that drastically impede social thriving. Ergo, this paper responds to the inextricability of punishment that link classrooms to prisons by introducing an abolitionist theological ethic to create educational sanctuaries.
III분과 : 감수곡선을 이용한 산림소유역 유출특성의 시계열 변화 평가 (2014)

본 연구는 주지하수 감수곡선을 이용하여 산림소유역의 유출특성을 밝히기 위하여 수행하였다. 2003년부터2011년까지 9년간 관측한 강우-유출량 자료를 이용하여 수문곡선 감수부의 시계열 변화를 분석하였다. 그 결과 산림소유역에서는 직접유출 감수계수가 기저유출의 감수계수 값보다 작았다. 또한 산림소유역에서의 직접유출량은 대유역에 비해 상당히 적은 양을 보였으며, 기저유출량은 차이가 크지 않았다. 시험유역에서 주지하수 감수곡선의 회귀식과 감수계수는 각각 y = 0.7528e-0.022x(R2=0.8938, 범위는 0.3 mm~0.8 mm), K = 0.978로 산출되었다. 주지하수 감수곡선과 연유출량과는 관련성이 큰 것으로 나타났는데, 유출량이 많으면 주지하수 감수곡선의 기울기가 완만해지고,유출량이 줄어들면 감수곡선의 기울기가 급해지는 것으로 나타났다. 또한 해를 거듭할수록 주지하수 감수곡선의 기울기가 완만해지는 경향이 나타나, 점차 기저유출량이 증가하는 것으로 판단하였다. 따라서 시험유역에서는 시간의경과와 함께 산림의 홍수조절기능 및 수원함양기능이 점진적으로 높아지는 것으로 나타났다.
KPC-Toolbox: Simple Yet Effective Trace Fitting Using Markovian Arrival Processes (2008)

We present the KPC-Toolbox, a collection of MATLAB scripts for fitting workload traces into Markovian arrival processes (MAPs) in an automatic way. We first present detailed sensitivity analysis that builds intuition on which trace descriptors are most important for queueing. This sensitivity analysis stresses the importance of matching higher-order correlations (i.e., joint moments) of the process inter-arrival times rather than higher order moments of the distribution and provides guidance on the relative importance of different descriptors on queueing. Given that the MAP parameterization space can be very large, we focus on first determining the order of the smallest MAP that can fit the trace well, using the Bayesian information criterion (BIC) for determining the best order-accuracy tradeoff. Having determined the order of the target MAP, the KPC-Toolbox automatically derives a MAP that captures accurately the most essential features of the trace. Extensive experimentation illustrates the effectiveness of the KPC-Toolbox in fitting traces that are well-documented in the literature as very challenging to fit, showing that the KPC-Toolbox provides a simple and powerful solution to fitting accurately trace data into MAPs.