gebhart/patrepeval huggingface dataset:
Adaptive Square-Root Unscented Particle Filtering Algorithm for Dynamic Navigation (2018)

This paper presents a new adaptive square-root unscented particle filtering algorithm by combining the adaptive filtering and square-root filtering into the unscented particle filter to inhibit the disturbance of kinematic model noise and the instability of filtering data in the process of nonlinear filtering. To prevent particles from degeneracy, the proposed algorithm adaptively adjusts the adaptive factor, which is constructed from predicted residuals, to refrain from the disturbance of abnormal observation and the kinematic model noise. Cholesky factorization is also applied to suppress the negative definiteness of the covariance matrices of the predicted state vector and observation vector. Experiments and comparison analysis were conducted to comprehensively evaluate the performance of the proposed algorithm. The results demonstrate that the proposed algorithm exhibits a strong overall performance for integrated navigation systems.
Programmable picosecond pulse generator in CMOS (2015)

In this paper, a scalable and reconfigurable architecture is presented for digitally programmable sub-THz waveform generation in CMOS. The architecture allows individual control of both amplitudes and phases of harmonic frequencies beyond f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</inf> to achieve waveform shaping. This is enabled through controlled interference of multiple traveling-waves with rich harmonic components and delays. As an example, inspired from mode-locked laser, picosecond pulse generation is demonstrated in CMOS with a measured pulse-width of 2.6ps and 0.46 mW output power for the pulse train. To the best of the authors' knowledge, this is the smallest pulse width demonstrated in integrated circuit technology with additional capability of dynamic reconfiguration. The chip is fabricated in 65nm LP CMOS process.
Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes (2012)

Rasal, belonging to the GAP1 subfamily of Ras GTPase-activating proteins (RasGAPs) with dual RasGAP/RapGAP specificity, is epigenetically silenced in several tumor types. Surprisingly, the isolated protein has GAP activity on Rap but not on Ras. Its membrane recruitment is regulated by interaction with calcium and lipids, which simultaneously induces its RasGAP activity through a yet unknown mechanism. Here we show that the interaction of Rasal with membranes induces Rasal RasGAP activity by spatial and conformational regulation, although it does not have any effect on its RapGAP activity. Not only is colocalization of Rasal and Ras in the membrane essential for RasGAP activation, but direct and Ca-dependent interaction between the tandem C2 domains of Rasal and lipids of the membrane is also required. Whereas the C2A domain binds specifically phosphatidylserine, the C2B domain interacts with several phosphoinositol lipids. Finally we show, that similar to the C2 domains of synaptotagmins, the Rasal tandem C2 domains are able to sense and induce membrane curvature by the insertion of hydrophobic loops into the membrane.
Adaptive fuzzy control of a variable speed power generating system with doubly excited reluctance machine (2002)

Fuzzy control methods are developed for a highly efficient variable speed constant frequency power generating system, with wind power generation as an example. In slip power recovery configuration, the system is composed of a doubly excited brushless reluctance-machine and a reduced rating power electronic converter unit linking the stator secondary circuit with the power line. The doubly excited brushless reluctance machine has high efficiency, high reliability and rugged construction. Under fuzzy logic control which enables superior dynamic performance, the operational speed is controlled to track the optimal power-speed profile of the wind turbine. Reactive power is independently controllable. Active and reactive power capacities of the system are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Efficacy and safety of estriol replacement therapy for climacteric women. (1995)

Estriol can be a safe and effective alternative in the relief of climacteric symptoms for postmenopausal women, but it cannot prevent the bone loss.
Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina (2006)

The mammalian retina comprises six major neuronal cell types and one glial type that are further classified into multiple subtypes based on their anatomical and functional differences. Nevertheless, how these subtypes arise remains largely unknown at the molecular level. Here, we demonstrate that the expression of Bhlhb5, a bHLH transcription factor of the Olig family, is tightly associated with the generation of selective GABAergic amacrine and Type 2 OFF-cone bipolar subtypes throughout retinogenesis. Targeted deletion of Bhlhb5 results in a significant reduction in the generation of these selective bipolar and amacrine subtypes. Furthermore, although a Bhlhb5-null mutation has no effect on the expression of bHLH-class retinogenic genes, Bhlhb5 expression overlaps with that of the pan-amacrine factor NeuroD and the expression of Bhlhb5 and NeuroD is negatively regulated by ganglion cell-competence factor Math5. Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes.
Influence of Musculoskeletal Conditions on Oral Health Among Older Adults (2008)

Both musculoskeletal disorders and diseases of the oral cavity are common and potentially serious problems among older persons, yet little attention has been given to the links between them. Several musculoskeletal diseases, including osteoporosis, Paget's disease, and arthritic disorders, may directly involve the oral cavity and contiguous structures. Drugs used to treat musculoskeletal diseases, including corticosteroids and bisphosphonates, increase the risk of suppression of the immune system and osteonecrosis of the jaw, respectively. Many people with disabling osteoarthritis, rheumatoid arthritis, and other conditions have difficulty practicing good oral hygiene and traveling to dental offices for professional help. Various inexpensive measures can help such individuals, including education of their caregivers and provision of antimicrobial mouthwashes and special toothbrushes.
CROSSLINKING AND REINFORCEMENT OF LIQUID RUBBER WITH MONOMER (II) (1977)

水酸基末端液状ポリブタジエンと無水マレイン酸の付加反応によるアダクトポリマーに, 種々の無機充てん剤を添加し, スチレン架橋を行った. カーボンブラックを充てん剤に用いると, 重合が著しく遅延され, 得られた硬化物の機械的性質は著しく悪くなった. 一方, 白色充てん剤であるホワイトカーボン及び炭酸カルシウムを用いると, 架橋反応が円滑に進行し, 機械的性質の比較的良好な硬化物が得られた. これらの結果より, 充てん剤の粒子表面の官能基がスチレンによる架橋硬化反応に影響を及ぼし, その補強効果にも影響すると考えられた.
Effect of Yag-laser anterior capsulotomy on the biochemical content of aqueous humor. (1988)

Elevation of prostaglandins and protein in the aqueous humor is an immediate response to Yag-laser anterior capsulotomy. There was a significant correlation between prostaglandins and thromboxane to the elevation of intraocular pressure. The elevation of protein concentration was proportional to the elevation of prostaglandin F1, but not to thromboxane. The biochemical changes in the aqueous humor were more severe as laser power was increased above 3 mj. While the role of prostaglandins in the elevation of intraocular pressure is uncertain, the present data recommend the selection of laser power below 3 mj to avoid pressure rise instead of inhibition of all prostaglandin synthesis by medication.
Studies on the photosensitizing properties of angelicin, an angular furocoumarin forming only monofunctional adducts with the pyrimidine bases of DNA. (1976)

The bioligical photosensitizing properties of furocoumarins are due to the formation of adducts with the pyrimidine bases of DNA under irradiation with long wavelength ultraviolet light. The greatest importance is attributed to the difunctional adducts, which form cross-linkings between the 2 strands of DNA. As angelicin, photoreacting with DNA, forms only monofunctional adducts, and therefore no cross-linkings, its photosensitizing properties have been studied in order to evaluate the ability of monofunctional adducts to produce biological effects. The results obtained studying the inhibition of DNA, RNA and protein synthesis in Ehrlich ascite tumor cells after irradiation in the presence of angelicin and psoralen (for a comparison), and the inhibition of the ability of identically treated cells to transmit the tumor showed a remarkable ability of monofunctional adducts to produce biological effects.
Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection (2016)

To investigate the beneficial effects of diosgenin (DG) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were measured in trimethyltin (TMT)-injected transgenic 2576 (TG) mice that had been pretreated with DG for 21 days. Multiple types of damage were successfully induced by Aβ-42 accumulation and TMT injection into the brains of TG mice. However, DG treatment significantly reduced the number of Aβ-stained plaques and dead cells in the granule cells layer of the dentate gyrus. Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group). Additionally, the concentration of nerve growth factor (NGF) was dramatically enhanced in TG+DG group, although it was lower in the TG+VC group than the non-transgenic (nTG) group. Furthermore, the decreased phosphorylation of downstream members in the TrkA high affinity receptor signaling pathway in the TG+VC group was significantly recovered in the TG+DG group. A similar pattern was observed in p75(NTR) expression and JNK phosphorylation in the NGF low affinity receptor signaling pathway. Moreover, superoxide dismutase (SOD) activity was enhanced in the TG+DG group, while the level of malondialdehyde (MDA), a marker of lipid peroxidation, was lower in the TG+DG group than the TG+VC group. These results suggest that DG could exert a wide range of beneficial activities for multiple types of brain damage through stimulation of NGF biosynthesis.
Yes, The APT Is Testable (1985)

ABSTRACT The Arbitrage Pricing Theory (APT) has been proposed as an alternative to the mean‐variance Capital Asset Pricing Model (CAPM). This paper considers the testability of the APT and points out the irrelevance for testing of the approximation error. We refute Shanken's objections, including his assertion that Roll's critique of the CAPM is applicable to the APT. We also explain the testability of the APT on subsets, and we explore the relationship between the APT and the CAPM.
The role of interface framework residues in determining antibody V<sub>H</sub>/V<sub>L</sub> interaction strength and antigen‐binding affinity (2006)

While many antibodies with strong antigen-binding affinity have stable variable regions with a strong antibody heavy chain variable region fragment (V(H))/antibody light chain variable region fragment (V(L)) interaction, the anti-lysozyme IgG HyHEL-10 has a fairly strong affinity, yet a very weak V(H)/V(L) interaction strength, in the absence of antigen. To investigate the possible relationship between antigen-binding affinity and V(H)/V(L) interaction strength, a novel phage display system that can switch two display modes was employed. We focused on the two framework region 2 regions of the HyHEL-10 V(H) and V(L), facing each other at the domain interface, and a combinatorial library was made in which each framework region 2 residue was mixed with that of D1.3, which has a far stronger V(H)/V(L) interaction. The phagemid library, encoding V(H) gene 7 and V(L) amber codon gene 9, was used to transform TG-1 (sup+), and the phages displaying functional variable regions were selected. The selected phages were then used to infect a nonsuppressing strain, and the culture supernatant containing V(H)-displaying phages and soluble V(L) fragment was used to evaluate the V(H)/V(L) interaction strength. The results clearly showed the existence of a key framework region 2 residue (H39) that strongly affects V(H)/V(L) interaction strength, and a marked positive correlation between the antigen-binding affinity and the V(H)/V(L) interaction, especially in the presence of a set of particular V(L) residues. The effect of the H39 mutation on the wild-type variable region was also confirmed by a SPR biosensor as a several-fold increase in antigen-binding affinity owing to an increased association rate, while a slight decrease was observed for the single-chain variable region.
Design of an Automatic Water Level Controller Using Mercury Float Switch (2014)

This paper presents the design of an automatic water level controller aimed at providing an appropriate control to pump water to an overhead thank when empty and automatically stop the pump when the tank is full. The system incorporates two mains contactor which are energized to provide a direct online start of the motor. An over load relay which senses the presence of excess current and disconnect the supply and a mercury flood switch which uses the Archimedes principle of floatation to provide the electrical contact to switch ON or OFF supply to the motor when the tank is empty or full respectively. This is capable of providing a seamless utilization of water at domestic and industrial level without causing spillage.
Antiepileptic drugs in the treatment of neuropathic pain (2001)

Antiepileptic drugs were initially designed to treat epileptic seizures, but are increasingly used in the treatment of neuropathic pain. Efficacy of the newer antiepileptic drugs has been confirmed in placebo-controlled studies for trigeminal neuralgia, postherpetic neuralgia, painful polyneuropathy and central poststroke pain. While standard antiepileptic drugs act as sodium channel blockers, the newer antiepileptics display additional mechanisms of action, including a potentiation of GABAergic inhibition, specific binding on a subtype of calcium channels, a reduced release of glutamate and a blockade of AMPA/kainate receptors. These mechanisms could account for their antiallodynic and antihyperalgesic effects demonstrated in animal models of neuropathic pain and also suggested for gabapentin and lamotrigine in humans. Additional studies are required to compare efficacy of newer versus standard antiepileptic drugs and to better define their place in comparison with other analgesics in the treatment of neuropathic pain.
Trickled Ethylene Gas Fruit Ripening and Colouring Rooms for On-farm Use (1984)

The methods and equipment currently being used In Queensland for on-farm fruit ripening and colouring by the trickled ethylene gas system are described. Design criteria and operating details of these rooms are given in the paper.
(α-NaYbF<sub>4</sub>:Tm<sup>3+</sup>)/CaF<sub>2</sub> Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging (2012)

We describe the development of novel and biocompatible core/shell (α-NaYbF(4):Tm(3+))/CaF(2) nanoparticles that exhibit highly efficient NIR(in)-NIR(out) upconversion (UC) for high contrast and deep bioimaging. When excited at ~980 nm, these nanoparticles emit photoluminescence (PL) peaked at ~800 nm. The quantum yield of this UC PL under low power density excitation (~0.3 W/cm(2)) is 0.6 ± 0.1%. This high UC PL efficiency is realized by suppressing surface quenching effects via heteroepitaxial growth of a biocompatible CaF(2) shell, which results in a 35-fold increase in the intensity of UC PL from the core. Small-animal whole-body UC PL imaging with exceptional contrast (signal-to-background ratio of 310) is shown using BALB/c mice intravenously injected with aqueously dispersed nanoparticles (700 pmol/kg). High-contrast UC PL imaging of deep tissues is also demonstrated, using a nanoparticle-loaded synthetic fibrous mesh wrapped around rat femoral bone and a cuvette with nanoparticle aqueous dispersion covered with a 3.2 cm thick animal tissue (pork).
New method for lightning location using optical ground wire (2006)

A new technology of lightning location is described, which is based on detecting the state of polarization (SOP) fluctuation of the laser light in the optic ground wire (OPGW). Compared with the conventional lightning location method, the new method is more accurate, more stable, and cheaper. Theories of Stokes parameters and Poincare sphere are introduced to analyze the SOP at the lightning strike point. It can be concluded that although the initial points of SOP on the Poincare sphere are random, the SOP fluctuation generated by lightning strike can still be accurately identified by detecting the velocity of polarization motion. A new algorithm to quantify the velocity is also introduced.
CMOS circuits for Gb/s serial data communication (1995)

The functional characteristics and design challenges associated with a variety of communication-related circuits are presented. These include the mixed-signal design and noise issues associated with high-speed clock generation and recovery for serial data communication. Hardware results are presented on the noise properties of common integrated voltage-controlled oscillator (VCO) circuits.
Where to Park? (2018)

Several smart cities around the world have begun monitoring parking areas in order to estimate free spots and help drivers that are looking for parking. The current results are indeed promising, however, this approach is limited by the high costs of sensors that need to be installed throughout the city in order to achieve an accurate estimation rate. This work investigates the extension of estimating parking information from areas equipped with sensors to areas that are missing them. To this end, similarity values between city neighborhoods are computed based on background data, i.e., from geographic information systems. Using the derived similarity values, we analyze the adaptation of occupancy rates from monitored- to unmonitored parking areas.
Atlas of Virus Diagrams (2023)

Authored by electron microscopists and leading members of the International Committee on Taxonomy of Viruses (ICTV), the Atlas of Virus Diagrams includes chapters on virus classification. The diagrams, selected for content and historic and aesthetic value, illustrate vertebrate, invertebrate, and plant bacterial viruses taken from English, French, and German language virological literature. The book presents this information in three sections: Overviews, including vertebrate and plant virusesViruses with cubic and helical symmetryViruses with binary symmetry (tailed bacteriophages).
Effects of Matrix Metalloproteinase-9 Gene Knock-Out on Morphological and Motor Outcomes after Traumatic Brain Injury (2000)

Matrix metalloproteinases (MMPs) belong to a class of extracellular proteinases responsible for maintaining and remodeling the extracellular matrix. In addition to multiple functions in normal physiology, abnormal MMP expression and activity may also participate in the pathophysiology of cerebral disease. Here, we show that MMP-9 (gelatinase B; EC.3.4.24.35) contributes to the pathophysiology of traumatic brain injury. After controlled cortical impact in mice, MMP-9 was increased in traumatized brain. Total MMP-9 levels at 24 hr were significantly increased as measured by a substrate cleavage assay. Zymograms showed that MMP-9 was elevated as early as 3 hr after traumatic brain injury, reaching a maximum at approximately 24 hr. Increased MMP-9 levels persisted for up to 1 week. Western blot analysis indicated increased profiles of MMP-9 expression that corresponded with the zymographic data. Knock-out mice deficient in MMP-9 gene expression were compared with wild-type littermates in terms of morphological and motor outcomes after trauma. Motor outcomes were measured at 1, 2, and 7 d after traumatic brain injury by the use of a rotarod device. MMP-9 knock-out mice had less motor deficits than wild-type mice. At 7 d, traumatic brain lesion volumes on Nissl-stained histological sections were significantly smaller in MMP-9 knock-out mice. These data demonstrate that MMP-9 contributes to the pathophysiology of traumatic brain injury and suggest that interruption of the MMP proteolytic cascade may be a possible therapeutic approach for preventing the secondary progression of damage after brain trauma.
Characterization of the Florida Fresh Fruit and Vegetable Industry Using Hydroponic Systems or Protected Agriculture Structures (2014)

UF/IFAS Extension faculty, allied industry representatives, and growers determined the need to assess the size and scope of the protected agriculture industry in 2013 by surveying growers in Florida. The primary focus was to document the types of protected agriculture structures, crops, and growing systems being used. In addition, secondary information on location of operations, pest concerns, expected expansion, etc. was collected on many operations. The results documented a significant expansion of the industry in terms of both size and scope. This 8-page fact sheet was written by Robert C. Hochmuth and Dilcia E. Toro, and published by the UF Department of Horticultural Sciences, August 2014. HS1240/HS1240: Characterization of the Florida Fresh Fruit and Vegetable Industry Using Hydroponic Systems or Protected Agriculture Structures (ufl.edu)
Rethinking the network stack for rack-scale computers (2014)

The rack is increasingly replacing individual servers as the basic building block of modern data centers. Fu-ture rack-scale computers will comprise a large number of tightly integrated systems-on-chip, interconnected by a switch-less internal fabric. This design enables thou-sands of cores per rack and provides high bandwidth for rack-scale applications. Most of the benefits promised by these new architectures, however, can only be achieved with adequate support from the software stack. In this paper, we take a step in this direction by focus-ing on the network stack for rack-scale computers. Us-ing routing and rate control as examples, we show how the peculiarities of rack architectures allow for new ap-proaches that are attuned to the underlying hardware. We also discuss other exciting research challenges posed by rack-scale computers. 1
Nanometer focusing of hard x rays by phase zone plates (1999)

Focusing of 8 keV x rays to a spot size of 150 and 90 nm full width at half maximum have been demonstrated at the first- and third-order foci, respectively, of a phase zone plate (PZP). The PZP has a numerical aperture of 1.5 mrad and focusing efficiency of 13% for 8 keV x rays. A flux density gain of 121 000 was obtained at the first-order focus. In this article, the fabrication of the PZP and its experimental characterization are presented and some special applications are discussed.