gebhart/patrepeval huggingface dataset:
A realistic comparison of biaxial performance of nylon 6,6 and nylon 6 fabrics used in passive restraints—airbags (1996)

Nylon has been the material of choice for airbag construction because of its specific strength and dimensional stability during deployment. Of the nylons, nylon 6,6 has been widely used in airbag construction. In this article, we attempted to compare the performance of several commercial nylon 6,6 and nylon 6 fabrics offered, for use, to the auto industry. The performance of four traditional nylon 6,6 fabrics are compared with identical fabrics made from nylon 6 fibers. We used a test procedure championed by Chrysler but was developed in our laboratory called the blister-inflation. This test mimics the biaxial deformation of airbag fabric in a manner similar to the deformation of airbag fabric during actual deployment. Several other engineering properties of interest in airbag application are also addressed in this article for comparison purposes. © 1996 John Wiley & Sons, Inc.
Inhibition of new vessel growth in mouse model of laser‐induced choroidal neovascularization by adiponectin peptide II (2009)

We have investigated the effect of adiponectin (APN) peptide II on new vessel growth in mouse model of choroidal neovascularization (CNV) or wet type age-related macular degeneration (AMD). Mice were injected intraperitoneally with APN peptide II, control peptide, or PBS on day 1-7 or day 5-14. APN, AdipoR1, PCNA, and VEGF localization was investigated using confocal microscopy, immunohistochemistry, and RT-PCR. APN peptide II decreased the relative area of FITC-dextran perfused vessels by 4-fold, PCNA expression by 3-fold, and the number of PCNA stained HUVEC and MAVEC cells by 38 and 46%, respectively. We concluded that APN peptide II inhibits CNV size on days 7 and 14 by inhibiting the proliferation of endothelial cells in vivo and in vitro. APN peptide II may have therapeutic potential to inhibit CNV or wet AMD.
Self-Collimating Unstable-Resonator Diode Lasers (1992)

Proposed unstable-resonator diode lasers produce solid, collimated output beams without external collimating optics. Simpler to construct, used as pumps for optical-fiber amplifiers in telecommunications, for other solid-state lasers, and sources of light for free-space communications.
A Practical Guide to Interpreting Microseismic Measurements (2011)

Abstract Thousands of hydraulic fracture treatments have been monitored in the past ten years using microseismic mapping, providing a wealth of measurements that show a surprising degree of diversity in event patterns. Interpreting the microseismic data to determine the geometry and complexity of hydraulic fractures continues to be focused on visualization of the event patterns and qualitative estimates of the "stimulated volume", which has led to wide variations and inconsistencies in interpretations. Comparing the energy input during a hydraulic fracture treatment and resultant energy released by microseismic events demonstrates that the seismic deformation is a very small portion of the total deformation. The vast majority of the energy is consumed in aseismic deformation (tensile opening) and fluid friction (Maxwell et al. 2008). Proper interpretation of microseismic measurements should account for both seismic and aseismic deformation, coupling the geomechanics of fracture opening and propagation with the shear failures that generate microseisms. Interpretation of microseismic measurements begins with an evaluation of location uncertainty, using signal-to-noise ratios and error ellipsoids, along with event moment magnitude. In some cases, microseismic event location uncertainty is erroneously interpreted as fracture complexity. The next step is to normalize the data and correct for observation well bias, both distance and azimuth, including use of seismic radiation patterns. Without these corrections fracture behavior from well to well or stage to stage (especially in horizontal wells) can easily be misinterpreted. Advanced geophysical processing that describes the failure mechanisms in more detail may also aid in the interpretation. The final step in the interpretation is to include the geomechanics of the overall process, accounting for the fracture treatment volumes injected, the net pressure in the hydraulic fracture(s) and the shear failures that generated the microseisms. This final, critical step is often overlooked when interpreting microseismic measurements. The paper provides a comprehensive, yet practical guide to the interpretation of microseismic measurements.
Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy (2015)

There are many RNA targets in the transcriptome to which small molecule chemical probes and lead therapeutics are desired. However, identifying compounds that bind and modulate RNA function in cellulo is difficult. Although rational design approaches have been developed, they are still in their infancies and leave many RNAs "undruggable". In an effort to develop a small molecule library that is biased for binding RNA, we computationally identified "drug-like" compounds from screening collections that have favorable properties for binding RNA and for suitability as lead drugs. As proof-of-concept, this collection was screened for binding to and modulating the cellular dysfunction of the expanded repeating RNA (r(CUG)(exp)) that causes myotonic dystrophy type 1. Hit compounds bind the target in cellulo, as determined by the target identification approach Competitive Chemical Cross-Linking and Isolation by Pull-down (C-ChemCLIP), and selectively improve several disease-associated defects. The best compounds identified from our 320-member library are more potent in cellulo than compounds identified by high-throughput screening (HTS) campaigns against this RNA. Furthermore, the compound collection has a higher hit rate (9% compared to 0.01-3%), and the bioactive compounds identified are not charged; thus, RNA can be "drugged" with compounds that have favorable pharmacological properties. Finally, this RNA-focused small molecule library may serve as a useful starting point to identify lead "drug-like" chemical probes that affect the biological (dys)function of other RNA targets by direct target engagement.
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor. (1998)

Decorin, a small leucine-rich proteoglycan, is capable of suppressing the growth of various tumor cell lines when expressed ectopically. In this report, we investigated the biochemical mechanism by which decorin inhibits cell cycle progression. In A431 squamous carcinoma cells, decorin proteoglycan or protein core induced a marked growth suppression, when either exogenously added or endogenously produced by a transgene. Decorin caused rapid phosphorylation of the EGF receptor and a concurrent activation of mitogen-activated protein (MAP) kinase signal pathway. This led to a protracted induction of endogenous p21, a potent inhibitor of cyclin-dependent kinases, and ultimate cell cycle arrest. Biglycan, a related proteoglycan, had no effect. Moreover, decorin activated the EGF receptor/MAP kinase/ p21 axis in cell lines of various histogenetic backgrounds. These results provide the first evidence that EGF and decorin converge functionally to regulate the cell cycle through activation of a common pathway which ultimately leads to growth suppression.
Treatment of Chemotherapy-Resistant Human Ovarian Cancer Xenografts in C.B-17/SCID Mice by Intraperitoneal Administration of <i>Clostridium perfringens</i> Enterotoxin (2005)

Ovarian cancer remains the most lethal gynecologic malignancy in the United States. Although many patients with advanced-stage disease initially respond to standard combinations of surgical and cytotoxic therapy, nearly 90% develop recurrence and inevitably die from the development of chemotherapy-resistant disease. The discovery of novel and effective therapy against chemotherapy-resistant/recurrent ovarian cancer remains a high priority. Using expression profiling, we and others have recently found claudin-3 and claudin-4 genes to be highly expressed in ovarian cancer. Because these tight junction proteins have been described as the low- and high-affinity receptors, respectively, for the cytotoxic Clostridium perfringens enterotoxin (CPE), in this study we investigated the level of expression of claudin-3 and/or claudin-4 in chemotherapy-naive and chemotherapy-resistant primary human ovarian cancers as well as their sensitivity to CPE treatment in vitro. We report that 100% (17 of 17) of the primary ovarian tumors tested overexpress one or both CPE receptors by quantitative reverse transcription-PCR. All ovarian tumors showed a dose-dependent cytotoxic effect to CPE in vitro. Importantly, chemotherapy-resistant/recurrent ovarian tumors were found to express claudin-3 and claudin-4 genes at significantly higher levels when compared with chemotherapy-naive ovarian cancers. All primary ovarian tumors tested, regardless of their resistance to chemotherapeutic agents, died within 24 hours to the exposure to 3.3 microg/mL CPE in vitro. In addition, we have studied the in vivo efficacy of i.p. CPE therapy in SCID mouse xenografts in a highly relevant clinical model of chemotherapy-resistant freshly explanted human ovarian cancer (i.e., OVA-1). Multiple i.p. administration of sublethal doses of CPE every 3 days significantly inhibited tumor growth in 100% of mice harboring 1 week established OVA-1. Repeated i.p. doses of CPE also had a significant inhibitory effect on tumor progression with extended survival of animals harboring large ovarian tumor burdens (i.e., 4-week established OVA-1). Our findings suggest that CPE may have potential as a novel treatment for chemotherapy-resistant/recurrent ovarian cancer.
<title>Simplified method of testing for convergence in fractal image coding schemes</title> (1996)

In fractal image coding the original image is approximated by a unique fixpoint of a contractive affine transformation. To ensure convergence at the decoder an eigenvalue calculation of the transformation matrix during the encoding process is necessary to admit scaling coefficients larger than one. Due to the huge dimension of the transformation matrix the eigenvalue calculation is in general computationally infeasible. This paper presents a method to reduce the dimension of this matrix dramatically. The result of this method is a simple rule to create the reduced matrix directly without using the original matrix. Based on this rule a hierarchical method is presented, which allows us to test rather general fractal coding schemes for convergence.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
<title>X-ray scatter suppression algorithm for cone-beam volume CT</title> (2002)

Developing and optimizing an x-ray scatter control and reduction technique is one big challenge for cone beam volume computed tomography (CBVCT) because CBVCT will be much less immune to scatter than fan-beam CT. X-ray Scatter reduces image contrast, increases image noise and introduces reconstruction error into CBVCT. To reduce scatter interference, a practical algorithm that is based upon the beam stop array technique and image sequence processing has been developed on a flat panel detector-based CBVCT prototype scanner. This paper presents beam stop array-based scatter correction algorithm and the evaluation results through phantom studies. The results indicate that the beam stop array-based scatter correction algorithm is practical and effective to reduce and correct x-ray scatter for a CBVCT imaging task.
Realistic Electric Field Mapping of Anisotropic Muscle During Electrical Stimulation Using a Combination of Water Diffusion Tensor and Electrical Conductivity (2017)

An electric field map obtained by an anisotropic reconstruction method showed different patterns from the results of the previous isotropic reconstruction method. Since accurate electric field mapping is important to correctly estimate the coverage of the electrical treatment, future studies should include more rigorous validations of the new method through <i>in vivo</i> and <i>in situ</i> experiments.
Digital manufacturing of biocompatible metal frameworks for complex dental prostheses by means of SLS/SLM (2026)

In recent years, digitizing and automation have gained an important place in the manufacturing of medical products. However, many dental parts are still being produced by manual and inefficient conventional methods. This paper presents a fully digital and fast procedure for the design and manufacturing of implant-supported frameworks for complex dental prostheses by means of Selective Laser Sintering (SLS) or Selective Laser Melting (SLM). Offering a digital solution to the dental profession implies a real challenge because patient and dentist set high requirements on quality, material and precision. During this study, frameworks were manufactured by SLS/SLM of stainless steel, Ti6Al4V and a dental CoCr-alloy. The accuracy of the final framework has been analyzed by studying the error accumulation of the successive steps in the proposed procedure. SLS/SLM allows an efficient and customized production of the complex biocompatible frameworks without lengthy manual pre- or post-processing and with a medically acceptable accuracy corresponding to the precision of a conventionally fabricated framework. © 2005 Taylor & Francis Group.
Identification of structurally altered estrogen receptors in human breast cancer by site-directed monoclonal antibodies (1995)

We have developed and characterized site-directed monoclonal (MAb) and polyclonal antibodies to a specific domain in the N-terminal A/B region in order to assess estrogen receptor (ER) structural integrity in human breast tumor samples. The antibodies (Abs) reacted specifically with the native (undenatured) ER from various species. The synthetic peptides competed effectively for ER binding to the Abs, suggesting site-specificity. The Abs recognized the activated (4S) and transformed (5S) but not the unactivated, untransformed, molybdate-stabilized (8S) ER, suggesting that the epitope is inaccessible in the 8S form. Some of these Abs reacted with ER bound to its responsive elements, as determined by gel mobility shift assay. To evaluate the structural integrity of ER in breast cancer, we have utilized a) ligand binding analysis for the hormone binding domain; b) site-directed MAb to the DNA-binding domain; and c) site-directed MAb to the N-terminal transactivation domain. Analysis of ER from 29 human breast tumors revealed that 10 out of 29 tumors (35%) contained ER with intact hormone-, DNA-, and N-terminal domains. Thirteen out of 29 tumors (approximately 45%) contained ER with intact hormone binding and N-terminal domains but were defective only in the DNA-binding domain. Three out of 29 tumors (approximately 10%) contained ER defective only in the N-terminal domain. Another subgroup of tumors (3/29; approximately 10%) had ER with normal hormone binding domain but were defective in both the DNA-binding and the N-terminal activation domains.(ABSTRACT TRUNCATED AT 250 WORDS)
Immunization with a Pentameric L1 Fusion Protein Protects against Papillomavirus Infection (2001)

The prophylactic papillomavirus vaccines currently in clinical trials are composed of viral L1 capsid protein that is synthesized in eukaryotic expression systems and purified in the form of virus-like particles (VLPs). To evaluate whether VLPs are necessary for effective vaccination, we expressed the L1 protein as a glutathione S-transferase (GST) fusion protein in Escherichia coli and assayed its immunogenic activity in an established canine oral papillomavirus (COPV) model that previously validated the efficacy of VLP vaccines. The GST-COPV L1 fusion protein formed pentamers, but these capsomere-like structures did not assemble into VLPs. Despite the lack of VLP formation, the GST-COPV L1 protein retained its native conformation as determined by reactivity with conformation-specific anti-COPV antibodies. Most importantly, the GST-COPV L1 pentamers completely protected dogs from high-dose viral infection of their oral mucosa. L1 fusion proteins expressed in bacteria represent an economical alternative to VLPs as a human papillomavirus vaccine.
Integrated Angle-of-Arrival Sensing and Simultaneous Bidirectional Communication Using a Cat’s eye Modulating Retroreflector (2009)

A bidirectional single-aperture modulating retroreflector is realized by superimposing a small low-frequency signal on the interrogating beam. Transmitted and received data are frequency-separated, enabling full-duplex operation and autodetection of illumination.
Adaptive Pacing During Ventricular Fibrillation (2003)

While it has been shown that pacing during ventricular fibrillation (VF) can capture a portion of the epicardium, little is known about the characteristics of the area captured or about whether adaptively changing the pacing rate during VF will increase the area captured. In six open-chested pigs, pacing during VF was performed from the center of a plaque containing 504 electrodes 2 mm apart in a21 x 24 array on the anterior right ventricle. Simultaneous recordings from the 504 electrodes were used to construct activation maps from which the area of epicardium captured by pacing was determined. Four pacing algorithms were examined: (1) fixed rate pacing at 95% of the median VF activation rate, (2 and 3) adaptive pacing in which the pacing timing and/or rate is reset in real time if capture is not obtained, and (4) pacing at a slowly increasing rate after initial capture. Regional capture, defined as control of the myocardium under at least 10 plaque electrodes, was achieved in 71% (92/129) of pacing episodes. The incidence of capture was not significantly different for pacing algorithms 1-3. The maximum area captured for each pacing episode with algorithms 1-3 was 3.8 +/- 2.0 cm2(mean +/- SD). Within each animal, the pattern of capture was similar among all pacing episodes, no matter which algorithm was use dr = 0.85 +/- 0.25). The region of greatest capture extended away from the pacing site along the long axis of the myocardial fibers. However, the area of captured epicardium toward the right ventricular side of the pacing electrode was 9.7 times greater than toward the left ventricular side. This principal direction toward the right ventricular side of the pacing electrode was the same direction traveled by the majority of VF activation fronts before capture occurred. The absence of recorded activations at the pacing site for 20 consecutive stimuli predicted 83% of the time that regional capture was present. With algorithm 4, the pacing rate could be increased 7.1%+/- 4.3%while maintaining capture; however, the area of capture progressively decreased as the pacing rate increased. While pacing from the anterior right ventricular epicardium during VF, the area of capture is repeatable and is markedly asymmetrical with almost 10 times as much epicardium captured on the side of the pacing electrode closest to the acute margin of the right ventricle as on the opposite side. This marked asymmetry is associated both with myofiber orientation and with the direction of spread of activation and hence the direction of dispersion of refractoriness during VF just before pacing is initiated. It is possible to perform adaptive pacing algorithms in real time during VF; however, the two adaptive algorithms tested did not capture significantly more epicardium than a simple fixed-rate pacing algorithm. Although it is possible to maintain capture while increasing the pacing rate during VF, the area of capture decreases.
Bacterin That Induces Anti-OspA and Anti-OspC Borreliacidal Antibodies Provides a High Level of Protection against Canine Lyme Disease (2008)

Groups of 15 laboratory-bred beagles were vaccinated and boosted with either a placebo or adjuvanted bivalent bacterin comprised of a traditional Borrelia burgdorferi strain and a unique ospA- and ospB-negative B. burgdorferi strain that expressed high levels of OspC and then challenged with B. burgdorferi-infected Ixodes scapularis ticks. The vaccinated dogs produced high titers of anti-OspA and anti-OspC borreliacidal antibodies, including borreliacidal antibodies specific for an epitope within the last seven amino acids at the OspC carboxy terminus (termed OspC7) that was conserved among pathogenic Borrelia genospecies. In addition, spirochetes were eliminated from the infected ticks that fed on the bacterin recipients, B. burgdorferi was not isolated from the skin or joints, and antibody responses associated specifically with canine infection with B. burgdorferi were not produced. In contrast, B. burgdorferi was recovered from engorged ticks that fed on 13 (87%) placebo-vaccinated dogs (P<0.0001), skin biopsy specimens from 14 (93%) dogs (P<0.0001), and joint tissue specimens from 8 (53%) dogs (P=0.0022). In addition, 14 (93%) dogs developed specific antibody responses against B. burgdorferi proteins, including 11 (73%) with C6 peptide antibodies (P<0.0001). Moreover, 10 (67%) dogs developed Lyme disease-associated joint abnormalities (P<0.0001), including 4 (27%) dogs that developed joint stiffness or lameness and 6 (40%) that developed chronic joint inflammation (synovitis). The results therefore confirmed that the bacterin provided a high level of protection against Lyme disease shortly after immunization.
High Thermal Conductivity of Gallium Nitride (GaN) Crystals Grown by HVPE Process (2007)

A relatively large sample of gallium nitride (GaN) was grown as a single crystal using the hydride vapor phase epitaxy (HVPE) process. The thermal diffusivity of the single crystal has been measured using a vertical-type laser flash method. The thermal expansion was measured using a dilatometer in order to estimate the thermal diffusivity with sufficient reliability. The effect of sample thickness and temperature on thermal diffusivity was evaluated. The specific heat capacity of GaN was also measured by using a differential scanning calorimeter. The thermal properties of single-crystal GaN have been compared with the measured thermal properties of single-crystal silicon carbide (SiC). The thermal conductivity of single-crystal GaN at room temperature is found to be 253±8.8% W/mK, which is approximately 60% of the value obtained for SiC. The excellent thermal property that is obtained in this study clearly indicates that GaN crystals are one of the promising materials for use in high-power-switching devices.
Local inversion of transient shear-wave propagation for elasticity and viscosity mapping in soft tissues (2005)

Observation of transient shear-wave propagation in soft tissue is of great interest for the study of tissue viscoelastic properties. In previous work, we introduced a technique, called Supersonic Shear Imaging (SSI), able to generate transient shear waves using the acoustic radiation force and image their propagation in real time in soft tissues. In this work, a local inverse problem of the shear wave propagation permitting the recovery of shear elasticity and viscosity is presented. Compressional and shear waves are decoupled by applying the curl operator to the experimental 2-D displacement field. The role of viscosity on the accuracy of the elasticity estimation is studied. The influence of out of plane shear propagation on the inversion algorithm is discussed. Finally, in media presenting shear viscoelasticity heterogeneities, finite difference simulations are used to study the spatial resolution of the algorithm and its sensitivity to the signal-to-noise ratio. Experiments on calibrated tissue-mimicking phantoms presenting different viscoelastic properties are presented validating the simulation results. First in vivo results on female breasts are presented.