gebhart/patrepeval huggingface dataset:
Motivações para a violência no contexto escolar sob a óptica do adolescente (2012)

Objective: to understand the motivations that lead to the practice of violence in the school context from the perspective of adolescents. Method: we used the qualitative method, and data collected through interviews. The data were evaluated using content analysis. Results: for adolescents, the reasons for school violence were issues related to affective relations between partners, disregard for the physical and social characteristics of the subjects, resistance to the imposition of rules, influence of family structure and drug use. Conclusion: the research shows that the source of violence is multifactorial roots. We stress the need to integrate actions from various sectors in the context of everyday practices of the school, the prospect of building a network capable of providing better care and achieve greater compliance of adolescents, guiding actions to empower them on their access rights services of health promotion
Potassium Carbonate as a Salt for Deep Eutectic Solvents (2013)

Deep Eutectic Solvents (DES) are emerging as new class of green solvents with the favorable properties of low cost, minimum volatility, biodegradability and suitability for many industrial applications.In an attempt to synthesize a new class of DES, potassium carbonate was used as a salt with glycerol as a hydrogen bond donor (HDB).The basic physical properties of this DES were measured at different temperatures and salt:HBD molar ratios.The physical properties measured included density, viscosity, surface tension, refractive index and pH at a temperature range of 20 -80 o C. The system didn't show a freezing points in DSC thermograms, however glass transition temperatures were observed.This system exhibits similar physico-chemical properties to other reported DES.The values of these properties indicated that the prepared DES may have great potential for industrial applications.
Clinical efficacy of laparoscopic and open method in the treatment of gastric cancer radical surgery (2017)

Objective
To compare the clinical efficacy of laparoscopic and open method in the treatment of gastric cancer radical surgery.


Methods
110 patients who underwent radical surgery for gastric cancer were selected.According to its different operation method, they were divided into observation group and control group, 55 cases in each group.The observation group received laparoscopic surgery, and the control group received open operation treatment.The general surgery situation, the C-reactive protein (CRP) levels at preoperation and postoperative 1, 7, 10d were compared in the two groups.


Results
The surgical incision length, intraoperative blood loss, postoperative bowel movements and postoperative hospital stay in the observation group were (24.6±3.7)cm, (99.9±31.8)mL, (5.8±2.7)d, (12.8±7.7)d respectively, which were significantly lower than (5.6±1.4)cm, (61.3±13.6)mL, (4.5±0.7)d, (9.2±3.9)d in the control group(t=31.472, 5.289, 3.194, 2.398, all P 0.05). CRP level at 1d preoperation, 1d postoperation, 7d postoperation, 10d postoperation of the control group were (18.21±3.67)mg/L, (42.96±7.28)mg/L, (22.88±4.35)mg/L, (15.89±4.34)mg/L respectively, which of the observation group were (17.82±3.57)mg/L, (29.97±4.58)mg/L, (16.01±3.16)mg/L, (8.65±1.77)mg/L respectively, it had no significant difference between the two groups at preoperative 1d (P>0.05), postoperative 1d both elevated obviously, postoperative 7 d, 10 d both significantly dropped than postoperative 1d, and the differences between the two groups were significant (t=7.497, 6.521, 8.339, all P<0.05). The incidence rate of complications was 5.45%(3/55) in the observation group, which of the control group was 18.18%(10/55), the difference between the two groups was statistically significant(χ2=6.371, P<0.05).


Conclusion
Compared with the traditional laparotomy, laparoscopic gastric cancer radical has mild trauma, rapid recovery, the effect is good, quite cure degree, which is worthy of clinical popularization and application.


Key words: 
Stomach neoplasms; Laparoscopy; Surgical procedures, operative; Comparative study
Six Biblical Sonatas (1983)

Johann Kuhnau. Six Biblical Sonatas. Hilda Jonas: Harpsichord. Sanjo-Music HJ 1004-1, 2, 3, 4 (1982). (Available from: SanjoMusic, P.O. Box 16422, San Francisco, California 94116.) Johann Jacob Kuhnau (1660-1722), J. S. Bach's immediate predecessor as Thomaskantor in Leipzig, is perhaps best known as the composer of the six Biblical Sonatas for solo keyboard. Published in 1700, this collection of sonatas is a noteworthy representative of programmatic instrumental music in the Baroque period; each of the six compositions illustrates musically a particular Old Testament drama. stories depicted by Kuhnau in this collection are: 1) Combat Between David and 2) Saul Healed by David's Music, 3) Wedding, 4) Hezekiah, Deathly Sick and Restored to Health, 5) Gideon, Saviour of Israel, and 6) Death and Burial. Kuhnau relates the biblical story before each sonata and prefaces each movement with a brief commentary on the action. recent release on the Sanjo-Music label of this work performed by pianist and harpsichordist Hilda Jonas is heralded on the record jacket as the first recorded presentation of Kuhnau's Biblical Sonatas. This statement is not exactly true; for Jonas's recording of the six sonatas was antedated most recently by Jorg Ewald Dahler's admirable interpretation of the same pieces on the Claves label (Claves LP 30-356/357), released in 1980, and a cursory check of existing discographies reveals that the complete Biblical Sonatas were also recorded by Gustav Leonhardt in 1969 on the Telefunken label (SAWT 9553/54-B). Although there is no mention of the harpsichord used on this recording, it soon becomes all too apparent that the instrument is modern in every respect. Tuned to a'=440, the harpsichord has a disposition of one sixteen-foot, two eight-foot, and one four-foot choirs, and, as nearly as I could tell, pedals. None of the harpsichords fabricated in Saxony in Kuhnau's time had such a disposition. Even the deluxe harpsichords made by the Hass firm in Hamburg did not have sixteenfoot choirs until several decades after the publication of Kuhnau's keyboard works. technical capacity of the modern harpsichord is used to full, if unstylistic, advantage on this recording: a large number of completely inappropriate registrational changes appear in any one movement (even to the point of changing registrations midway through the initial statement of a fugue subject in Jacob's Wedding), bass passages are executed inarticulately with the solo sixteen-foot choir (in the casca Goliath section of The Combat Between David and Goliath, for example), and somber instrumental recitatives are performed with all four choirs engaged. …
S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates (2021)

Abstract SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
Gain-distributed feedback filters (1995)

Equivalent circuits are developed for gain-distributed feedback filters. The filters can be tuned by endloading. Side-coupling of the filters to a signal waveguide results in channel-dropping filters. These active filters suppress undesired resonances more effectively than passive filters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nitric Oxide in Hypertension and Renal Diseases (1995)

Nitric oxide (NO) is intimately involved in the regulation of vascular tone, renal haemodynamics and sodium balance. The physiological actions of NO suggest important vascular and renal protective roles for NO. When produced in large amounts, however, NO may also mediate cytotoxic effects. Increasing evidence suggests that endothelial function, notably the NO pathway, may be compromised in hypertension. It is not known, however, whether changes in endothelial function are primary or secondary to the development of hypertension. In renal diseases evidence for both excessive and deficient activity of NO pathway has been found. Increased glomerular production of NO via inducible NO synthase (NOS) with potential cytotoxic consequences has been demonstrated in experimental acute glomerulonephritis. On the other hand, indirect evidence obtained by means of NOS inhibitors point out to an important renoprotective role for NO in renal diseases. NO may counteract disease progression in renal diseases by preventing glomerular microthrombi, maintaining renal perfusion and medullary oxygenation, and via its anti-inflammatory/antiproliferative effects. However, these beneficial effects of NO may be compromised (endothelial and/or tubular dysfunction) in chronic nephropathies resulting in an accelerated course of renal disease. In future, more specific inhibitors and activators of different NOS isoforms are needed to elucidate the role of NO in various renal diseases in detail, and for treatment strategies aimed at modifying the NO pathway.
Towards Organic Zeolites and Inclusion Catalysts: Heptazine Imide Salts Can Exchange Metal Cations in the Solid State (2017)

Highly crystalline potassium (heptazine imides) were prepared by the thermal condensation of substituted 1,2,4-triazoles in eutectic salt melts. These semiconducting salts are already known to be highly active photocatalysts, for example, for the visible-light-driven generation of hydrogen from water. Herein, we show that within the solid-state structure, potassium ions can be exchanged to other metal ions while the crystal habitus is essentially preserved.
Reconfigurable power divider and combiner with variable power ratio (2004)

This paper presents the design of a power divider and combiner with variable power ratios. The essential idea is to use the operating principle of coupled-line coupler. The couple-line coupler, which has control switches at the coupled and the isolation ports, offer several different operating conditions depending on the state of the switches. By means of changing the terminating-state of the coupled and the isolation ports, short or open, the power ratio becomes 1:1 or 1:0. The input power is either equally divided into two output ports or delivered to the one output port exclusively.
Improved ε-poly-l-lysine production of Streptomyces sp. FEEL-1 by atmospheric and room temperature plasma mutagenesis and streptomycin resistance screening (2015)

To enhance the ε-poly-l-lysine (ε-PL) productivity of Streptomyces sp. FEEL-1, a novel breeding strategy of atmospheric and room temperature plasma (ARTP) mutagenesis with streptomycin resistance screening was developed. After three rounds of recursive breeding, one strain designated AS3-14 was selected with a ε-PL yield of 2.91 g/L in shake-flask fermentation, which was elevated by 66.3 % compared to that of the parent strain FEEL-1. Subsequent batch and fed-batch fermentation was performed in a 5 L fermenter, and 8.2 g/L and 41.2 g/L ε-PL productions were achieved, which were 49.1 % and 68.1 % higher, respectively, than those of the parent strain. Analysis of enzyme activities indicated that key enzymes, e.g., hexokinase, pyruvate kinase, citrate synthase and aspartate kinase, were more active in the mutant AS3-14 than in FEEL-1, which might explain the enhanced ε-PL productivity. The results of amplified fragment length polymorphism analysis indicated that the genomic DNA of AS3-14 became more variable after ARTP mutagenesis. Therefore, ARTP combined with streptomycin resistance is an efficient breeding approach for the rapid evolution of ε-PL-producing Streptomyces strains.
Optimal Deconvolution of Transcriptional Profiling Data Using Quadratic Programming with Application to Complex Clinical Blood Samples (2011)

Large-scale molecular profiling technologies have assisted the identification of disease biomarkers and facilitated the basic understanding of cellular processes. However, samples collected from human subjects in clinical trials possess a level of complexity, arising from multiple cell types, that can obfuscate the analysis of data derived from them. Failure to identify, quantify, and incorporate sources of heterogeneity into an analysis can have widespread and detrimental effects on subsequent statistical studies.We describe an approach that builds upon a linear latent variable model, in which expression levels from mixed cell populations are modeled as the weighted average of expression from different cell types. We solve these equations using quadratic programming, which efficiently identifies the globally optimal solution while preserving non-negativity of the fraction of the cells. We applied our method to various existing platforms to estimate proportions of different pure cell or tissue types and gene expression profilings of distinct phenotypes, with a focus on complex samples collected in clinical trials. We tested our methods on several well controlled benchmark data sets with known mixing fractions of pure cell or tissue types and mRNA expression profiling data from samples collected in a clinical trial. Accurate agreement between predicted and actual mixing fractions was observed. In addition, our method was able to predict mixing fractions for more than ten species of circulating cells and to provide accurate estimates for relatively rare cell types (<10% total population). Furthermore, accurate changes in leukocyte trafficking associated with Fingolomid (FTY720) treatment were identified that were consistent with previous results generated by both cell counts and flow cytometry. These data suggest that our method can solve one of the open questions regarding the analysis of complex transcriptional data: namely, how to identify the optimal mixing fractions in a given experiment.
RCoal: Mitigating GPU Timing Attack via Subwarp-Based Randomized Coalescing Techniques (2018)

Graphics processing units (GPUs) are becoming default accelerators in many domains such as high-performance computing (HPC), deep learning, and virtual/augmented reality. Recently, GPUs have also shown significant speedups for a variety of security-sensitive applications such as encryptions. These speedups have largely benefited from the high memory bandwidth and compute throughput of GPUs. One of the key features to optimize the memory bandwidth consumption in GPUs is intra-warp memory access coalescing, which merges memory requests originating from different threads of a single warp into as few cache lines as possible. However, this coalescing feature is also shown to make the GPUs prone to the correlation timing attacks as it exposes the relationship between the execution time and the number of coalesced accesses. Consequently, an attacker is able to correctly reveal an AES private key via repeatedly gathering encrypted data and execution time on a GPU. In this work, we propose a series of defense mechanisms to alleviate such timing attacks by carefully trading off performance for improved security. Specifically, we propose to randomize the coalescing logic such that the attacker finds it hard to guess the correct number of coalesced accesses generated. To this end, we propose to randomize: a) the granularity (called as subwarp) at which warp threads are grouped together for coalescing, and b) the threads selected by each subwarp for coalescing. Such randomization techniques result in three mechanisms: fixed-sized subwarp (FSS), random-sized subwarp (RSS), and random-threaded subwarp (RTS). We find that the combination of these security mechanisms offers 24- to 961-times improvement in the security against the correlation timing attacks with 5 to 28% performance degradation.
Lead‐Free Halide Rb<sub>2</sub>CuBr<sub>3</sub> as Sensitive X‐Ray Scintillator (2019)

Scintillators are widely utilized for radiation detections in many fields, such as nondestructive inspection, medical imaging, and space exploration. Lead halide perovskite scintillators have recently received extensive research attention owing to their tunable emission wavelength, low detection limit, and ease of fabrication. However, the low light yields toward X-ray irradiation and the lead toxicity of these perovskites severely restricts their practical application. A novel lead-free halide is presented, namely Rb<sub>2</sub> CuBr<sub>3</sub> , as a scintillator with exceptionally high light yield. Rb<sub>2</sub> CuBr<sub>3</sub> exhibits a 1D crystal structure and enjoys strong carrier confinement and near-unity photoluminescence quantum yield (98.6%) in violet emission. The high photoluminescence quantum yield combined with negligible self-absorption from self-trapped exciton emission and strong X-ray absorption capability enables a record high light yield of ≈91056 photons per MeV among perovskite and relative scintillators. Overall, Rb<sub>2</sub> CuBr<sub>3</sub> provides nontoxicity, high radioluminescence intensity, and good stability, thus laying good foundations for potential application in low-dose radiography.
Comprehensive review of neurophysiologic basis and diagnostic interventions in managing chronic spinal pain. (2009)

These guidelines include the evaluation of evidence for diagnostic interventional procedures in managing chronic spinal pain and recommendations. However, these guidelines do not constitute inflexible treatment recommendations. These guidelines also do not represent a "standard of care."
Multi-Fiber Tractography Visualizations for Diffusion MRI Data (2013)

In recent years, several new diffusion MRI approaches have been proposed to explore microstructural properties of the white matter, such as Q-ball imaging and spherical deconvolution-based techniques to estimate the orientation distribution function. These methods can describe the estimated diffusion profile with a higher accuracy than the more conventional second-rank diffusion tensor imaging technique. Despite many important advances, there are still inconsistent findings between different models that investigate the "crossing fibers" issue. Due to the high information content and the complex nature of the data, it becomes virtually impossible to interpret and compare results in a consistent manner. In this work, we present novel fiber tractography visualization approaches that provide a more complete picture of the microstructural architecture of fiber pathways: multi-fiber hyperstreamlines and streamribbons. By visualizing, for instance, the estimated fiber orientation distribution along the reconstructed tract in a continuous way, information of the local fiber architecture is combined with the global anatomical information derived from tractography. Facilitating the interpretation of diffusion MRI data, this approach can be useful for comparing different diffusion reconstruction techniques and may improve our understanding of the intricate white matter network.
Identification of Novel Androgen Receptor Antagonists Using Structure- and Ligand-Based Methods (2013)

Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). The AR hormone-binding site (HBS) is intensively studied and represents the target area for current antiandrogens including Bicalutamide and structurally related Enzalutamide. As resistance to antiandrogens invariably emerges in advanced prostate cancer, there exists a high medical need for the identification and development of novel AR antagonists of different chemotypes. Given the wealth of structural information on the AR in complex with a variety of ligands, we have applied an integrated structure- and ligand-based virtual screening methodology to identify novel AR antagonists. Virtual hits generated by a consensus voting approach were experimentally evaluated and resulted in the discovery of a number of structurally diverse submicromolar antagonists of the AR. In particular, one identified compound demonstrated anti-AR potency in vitro that is comparable to the clinically used Bicalutamide. These results set a ground for the development of novel classes of PCa drugs that are structurally different from current AR antagonists.
Residue computations in rings of algebraic integers (2002)

Recent work has focused on doing residue computations that use quantization within a particular dense ring of integers in the complex plane. That work is generalized, and it is shown that a class of cubic integers provides a more efficient and less costly solution than other rings of integers which have been considered previously. In addition, it is shown that certain quartic integer rings provide a simple solution to the problem of approximating roots of unity by using fields of lower degree. In addition, algorithms for approximating real and complex numbers with specific integer rings are developed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists (2018)

Evidence supports the use of ketamine for chronic pain, but the level of evidence varies by condition and dose range. Most studies evaluating the efficacy of ketamine were small and uncontrolled and were either unblinded or ineffectively blinded. Adverse effects were few and the rate of serious adverse effects was similar to placebo in most studies, with higher dosages and more frequent infusions associated with greater risks. Larger studies, evaluating a wider variety of conditions, are needed to better quantify efficacy, improve patient selection, refine the therapeutic dose range, determine the effectiveness of nonintravenous ketamine alternatives, and develop a greater understanding of the long-term risks of repeated treatments.
Supratentorial malignant gliomas of childhood (1984)

Twenty-seven patients aged 1 to 18 years harboring supratentorial (20 in the cerebrum and seven in the thalamus) malignant gliomas were treated between 1975 and 1982. There were four glioblastomas multiforme, 14 anaplastic astrocytomas, and nine malignant gliomas. All patients had a subtotal resection or biopsy as the initial procedure and received postoperative radiation therapy (RT). Fifteen of 27 patients were treated by RT alone; 14 had tumor progression with a median time to tumor progression (MTP) of 65 weeks. Twelve patients were treated with chemotherapy as an adjuvant to RT; only seven had tumor recurrence, with an MTP of 130 weeks. Of the 21 patients with recurrent tumors in both groups, 18 were treated with chemotherapy alone, or chemotherapy with a second surgical procedure or second course of RT. For all histological grades of tumor, the MTP for first recurrence was 75 weeks and the median survival time was 180 weeks. Age at initial diagnosis was found to be a statistically significant prognostic factor, with patients younger than 10 years of age surviving longer than patients aged over 10 years (p = 0.02).