gebhart/patrepeval huggingface dataset:
Regulation of food intake and body weight in rats by the synthetic heme analogue cobalt protoporphyrin (1991)

Cobalt protoporphyrin (CoPP) in single subcutaneous doses produces prolonged weight loss in adult and aged male rats. The altered body weight level in treated animals is actively defended against starvation or overfeeding over prolonged time periods (greater than 50-100 days). The actions of CoPP on appetite and body weight regulation are biphasic, comprising an initial period of hypophagia, probably mediated centrally, until a particular body weight level is attained. Resumption of normal calorie intake follows, although lowered body weight levels are sustained, suggesting an additional action of the compound on peripheral substrate metabolism. Controlled decrements in body weight can be produced by repetitive low-dose CoPP treatment (e.g., 1 mumol/kg body wt weekly); low-dose regimens do not elicit altered hormonal homeostasis or aberrations in heme/cytochrome P-450 regulation that have been observed following larger doses (25-50 mumol/kg body wt) of the compound. CoPP may be a valuable probe with which to explore the role of heme-related molecules in the regulation of appetite and body weight.
Differential GPS-Based Ultra-High Accuracy Real Time Attitude Determination (2011)

Real time determination of rotational motion relies on GPS and inertial measurements. The three rotational angles, roll, pitch and yaw (or heading), can be determined by employing a Kalman filter that blends GPS measurements with gyroscope and accelerometer measurements. Due to presence of earth gravity, roll and pitch can be determined to an accuracy of about 0.025 milliradians in a high quality inertial navigation system. However, heading accuracy is typically around 1 to 2 milliradians for a navigation system that experiences low dynamics. In this paper, we propose a novel differential GPS-based technique that relies on high integrity carrier phase integer ambiguity resolution to achieve heading accuracy on the order of 0.05 milliradians, which is more than 20 times better than that of conventional technology. The new approach not only can achieve ultra-high accuracy in heading, but also provides high integrity assurance suitable for safety-of-life applications. In this paper, relevant differential GPS and inertial navigation technology is briefly reviewed. A complete high data rate real time attitude determination system is proposed. A system performance simulation tool was developed in Matlab/SimulinkTM to model ship motion under various sea states, realistic GPS and navigation-grade inertial sensor performance, conventional GPS/inertial navigation processing, attitude determination via differential GPS processing, and final heading updates that achieves ultra-high accuracy. We have conducted system performance studies, and the results have demonstrated that our proposed system achieves ultra-high heading accuracy with high integrity. Furthermore, the proposed system can be readily built by using existing GPS and inertial sensor technologies.
ATHENA++ (2020)

Natural Language Interfaces to Databases (NLIDB) systems eliminate the requirement for an end user to use complex query languages like SQL, by translating the input natural language (NL) queries to SQL automatically. Although a significant volume of research has focused on this space, most state-of-the-art systems can at best handle simple select-project-join queries. There has been little to no research on extending the capabilities of NLIDB systems to handle complex business intelligence (BI) queries that often involve nesting as well as aggregation. In this paper, we present Athena++, an end-to-end system that can answer such complex queries in natural language by translating them into nested SQL queries. In particular, Athena++ combines linguistic patterns from NL queries with deep domain reasoning using ontologies to enable nested query detection and generation. We also introduce a new benchmark data set ( FIBEN ), which consists of 300 NL queries, corresponding to 237 distinct complex SQL queries on a database with 152 tables, conforming to an ontology derived from standard financial ontologies (FIBO and FRO). We conducted extensive experiments comparing Athena++ with two state-of-the-art NLIDB systems, using both FIBEN and the prominent Spider benchmark. Athena++ consistently outperforms both systems across all benchmark data sets with a wide variety of complex queries, achieving 88.33% accuracy on FIBEN benchmark, and 78.89% accuracy on Spider benchmark, beating the best reported accuracy results on the dev set by 8%.
The pharmacology and therapeutic potential of (-)-huperzine A (2012)

(-)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (-)-huperzine A (1). Synthetic studies of (-)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.
HLA‐DR gene frequencies in the Japanese population obtained by oligonucleotide genotyping (1991)

We determined HLA-DRB types of 375 randomly chosen healthy Japanese donors using a set of 29 different sequence-specific oligonucleotide (SSO) probes directed against various DRB alleles. Except for a few cases, these SSOs enabled us to identify 33 different DRB types including those detectable only by SSO genotyping. Gene frequencies were calculated for each of the DRB types identified. The "blank" frequency calculated by our SSO typing was essentially zero, in contrast to the considerably high "blank" frequencies reported at serological HLA-DR or cellular HLA-D workshops. This indicates that almost all of the DRB types in the Japanese population are positively detectable by our SSO typing. By comparing the gene frequencies for each of the DR types obtained by our SSO typing with those obtained by immunological typing at workshops, significant differences were observed for several of the DR types.
An instrument for measuring the static and dynamic response to shear at the air/water interface and of insoluble monolayers: some new insights into two-dimensional phases (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn instrument for measuring the static and dynamic response to shear at the air/water interface and of insoluble monolayers: some new insights into two-dimensional phasesB. M. Abraham, K. Miyano, and J. B. KettersonCite this: Ind. Eng. Chem. Prod. Res. Dev. 1984, 23, 2, 245–249Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/i300014a014https://doi.org/10.1021/i300014a014research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Reconstructing transient acoustic field resulting from an explosion (2004)

Generalized Helmholtz equation least squares (HELS) formulations for reconstructing transient acoustic radiation from an arbitrary object subject to arbitrarily time-dependent excitations are developed. Laplace transform is employed to build a transfer matrix for a multi-input multi-output system and reconstructed signals are obtained using convolution with respect to the input data in the time domain directly. Stability of solutions is realized by controlling the pole-residue locations in the Laplace domain. To facilitate calculations of the poles and residues, ztransform is utilized. To validate this general transient HELS formulation, the reconstructed pressure histories are compared with those measured by pressure sensors at the same locations. Space-time tomography resulting from different charges is produced, and the acoustic pressure distribution over the entire time record is reconstructed. It is interesting to notice that this transient HELS formulation enables one to trace time histories of blast pressures back to the explosion location. In other words, it is possible to reconstruct an explosion back in space and time based on the time-domain signals measured at a later time. [Work supported by NSF.]
Cooperation-Multiuser Diversity Tradeoff in Wireless Cellular Networks (2009)

We introduce a new multiuser diversity scheme for interference management in cellular networks. A base station with K antennas communicates with at most K out of M mobile stations. It is proven that, if K ¿ M, then K independent data streams can be transmitted to K mobile stations with no need for cooperative joint decoding by such stations. This result is based on a new multiuser diversity concept that allows parallel communication in the network without any cooperation among mobile stations. If the network does not have enough mobile stations, then some of the users need to jointly decode their corresponding data streams. The result suggests the existence of a tradeoff between multiuser diversity and cooperation in the downlink of cellular networks. Our interference management approach is based on a new multiuser diversity concept that achieves the capacity of dirty paper coding (DPC) asymptotically. Surprisingly, this gain is achieved without requiring full channel state information (CSI) and only K integers related to CSI are fed back from mobile stations to the base station. An additional advantage of this scheme is the fact that the encoding and decoding of signals for this distributed MIMO system is based on simple point-to-point communications.
Improvement of P-channel SOI LDMOS transistor by adapting a new tapered oxide technique (1999)

On-resistance of P-channel REduced SURface Field (RESURF) lateral double-diffused MOS (LDMOS) transistors has been improved by using a new tapered TEOS field oxide on the drift region of the devices. The new tapered oxidation technique provides better uniformity, less than 3%, and reproducibility. With the similar breakdown voltage (V/sub B/), at V/sub gs/=-5.0 V, the specific on-resistance (R/sub sp/) of the LDMOS with the tapered field oxide is about 31.5 m/spl Omega//spl middot/cm/sup 2/, while that of the LDMOS with the conventional field oxide is about R/sub sp/=57 m/spl Omega//spl middot/cm/sup 2/. The uniformities of R/sub sp/ and V/sub B/ are less than 5 and 3%, respectively.
Inferring Web API Descriptions from Usage Data (2015)

We describe a set of techniques to infer structured descriptions of web APIs from usage examples. Using trained classifiers, we identify fixed and variable segments in paths, and tag parameters according to their types. We implemented our techniques and evaluated their precision on 10 APIs for which we obtained: 1) descriptions, manually written by the API maintainers, and 2) server logs of the API usage. Our experiments show that our system is able to reconstruct the structure of both simple and complex web API descriptions, outperforming an existing tool with similar goals. Finally, we assess the impact of noise in the input data on the results of our method.
Ligand Conjugated Low-Density Lipoprotein Nanoparticles for Enhanced Optical Cancer Imaging in Vivo (2007)

LDL particles are high-capacity nanocarriers with precisely controlled size and are naturally biocompatible, biodegradable, and nonimmunogenic. However, their utilities as drug carriers are limited by the narrow purview of LDL receptor-positive tumors. Here, we synthsized a ligand-conjugated, NIR-labeled LDL that enables the first in vivo demonstration of rerouting LDL from LDL receptors to selected alternate receptors, thus drastically expanding the range of using LDL particles as nanocarriers for in vivo cancer imaging and treatment.
Role of Solubility, Permeability and Absorption in Drug Discovery and Development (2015)

While drug absorption, one of the most important determinants of systemic drug availability, is difficult to measure in vivo, there are in vitro techniques for determining solubility and permeability, the principal components of drug absorption. Solubilization approaches have led to the development of formulations with improved in vivo absorption. Permeability is influenced by the physicochemical properties of drugs and by biological factors such as pH, enzymes, transporters, and transit time; thus, not surprisingly, it shows larger inter-laboratory variability than solubility values. This variability prevents the pooling of in vitro data from multiple laboratories to create large and reliable databases for the development of in silico models that could be used to predict in vivo absorption. Alternatively, efforts have been made to develop better in vitro models of in vivo absorption. For example, the In vitro Dissolution Absorption System (IDAS) model allows concurrent evaluation of solubility and permeability across Caco-2 monolayers, after application of drug formulations in powder form (i.e. a macerated tablet or capsule). This system is likely to help fill the void between traditional in vitro measurements and in vivo drug absorption by facilitating formulation development and the prediction of the in vivo performance of drug formulations from in vitro dissolution and permeability data.
Influence of Eccentric Vortex to Performance of Cross Flow Fan (2015)

The flow in the cross flow fan is different from conventional turbo-machinery. The air passes the blades twice and the motion of the blades forms an eccentric vortex within the impeller. It is presented in this paper that the flow in the cross flow fan is divided to four parts; inflow, outflow, casing and tongue parts. The blade load is large in the outflow part and the circumferential variation of it is large. The pressure rise in the fan is higher at the short tongue than at the original tongue, but the efficiency is opposite to the pressure rise characteristics. The eccentric vortex emerges near the tongue in the impeller, and when the short tongue is used, the position of it moves to the outflow part. The energy increment in the impeller is different in circumferential position, that it is very large at the outflow part. The form of the eccentric vortex is closely relating to the fan performance, but the strength of it is not so large relating to it.
Versatile Detection and Monitoring of Ionizing Radiation Treatment Using Radiation-Responsive Gel Nanosensors (2022)

Modern radiation therapy workflow involves complex processes intended to maximize the radiation dose delivered to tumors while simultaneously minimizing excess radiation to normal tissues. Safe and accurate delivery of radiation doses is critical to the successful execution of these treatment plans and effective treatment outcomes. Given extensive differences in existing dosimeters, the choice of devices and technologies for detecting biologically relevant doses of radiation has to be made judiciously, taking into account anatomical considerations and modality of treatment (invasive, e.g., interstitial brachytherapy vs noninvasive, e.g., external-beam therapy radiotherapy). Rapid advances in versatile radiation delivery technologies necessitate new detection platforms and devices that are readily adaptable into a multitude of form factors in order to ensure precision and safety in dose delivery. Here, we demonstrate the adaptability of radiation-responsive gel nanosensors as a platform technology for detecting ionizing radiation using three different form factors with an eye toward versatile use in the clinic. In this approach, ionizing radiation results in the reduction of monovalent gold salts leading to the formation of gold nanoparticles within gels formulated in different morphologies including one-dimensional (1D) needles for interstitial brachytherapy, two-dimensional (2D) area inserts for skin brachytherapy, and three-dimensional (3D) volumetric dose distribution in tissue phantoms. The formation of gold nanoparticles can be detected using distinct but complementary modes of readout including optical (visual) and photothermal detection, which further enhances the versatility of this approach. A linear response in the readout was seen as a function of radiation dose, which enabled straightforward calibration of each of these devices for predicting unknown doses of therapeutic relevance. Taken together, these results indicate that the gel nanosensor technology can be used to detect ionizing radiation in different morphologies and using different detection methods for application in treatment planning, delivery, and verification in radiotherapy and in trauma care.
High-Frequency Fault Component-Based Distance Protection for Large Renewable Power Plants (2020)

Renewable energy sources (RESs) are directly or indirectly connected to the grid through power electronic devices and the short-circuit current exhibits characteristics such as limited amplitude, nonpower frequency, and controlled phase angle, which may lead to the malfunction of the RES-side distance protection on the transmission line. In order to solve this problem, a distance protection method based on the high-frequency fault component is proposed. The voltage drop caused by the fault has a full frequency component and this can be extracted by wavelet transform. After that, the high-frequency impedance models of the inverter-interfaced renewable energy generator and the doubly-fed induction generator are established and the frequency selection principle that makes them have the stable phase angle is determined. On this basis, the internal and external faults can be determined by comparing the magnitude of high-frequency operating voltage and high-frequency voltage at the fault point. This method eliminates the influence of frequency offset and weak feed of RESs using high-frequency signals generated by voltage drops at the fault point and can tolerate some noise. At the same time, due to the larger radius of impedance circle at the high-frequency range, this method has a strong ability to withstand the fault resistance. The experimental results and the field-testing data verify the effectiveness of the method.
A content-based search engine for VRML databases (2002)

This paper presents a new approach for the classification and retrieval of three-dimensional images and models from databases. A set of retrieval algorithms is introduced. These algorithms are content-based, meaning that the input is, not made out of keywords but of three-dimensional models. Tensor of inertia, distribution of normals and distribution of cords are used to describe each model. The database can be searched by scale, shape or color or any combination of these parameters. A user friendly interface makes the retrieval operation simple and intuitive and allows to edit reference models according to the specifications of the user. Experimental results using a database of more than 400 range images and 1000 VRML models are presented.
A new technique for the efficient solution of singular circuits (2002)

Singular circuits are those that have a continuum of solutions (or no solution) and are characterized by rank deficiency in the (linearized) circuit matrix. Such circuits often arise in practice-examples are filters with poles at zero, chains of transmission gates that are off, and circuits that rely on charge storage and transfer. In this paper, a technique for the efficient solution of such circuits is presented. The method is based on solving for the minimum-least-squares solution of the singular system. Unlike traditional methods for least squares solution, the new approach exploits the sparsity of the circuit matrix, making it practical for large industrial circuits. The method is best for applications with relatively small singular subspaces, as is the case in most circuits. Applications to industrial designs testify to the efficacy of the new technique; an example in which more than a week of design time would have been saved is presented.
Selection of a new scallop strain, QN‐2, from the backcross of Peruvian scallop × bay scallop F <sub>1</sub> hybrids with bay scallops (2019)

Cross-breeding has been successfully applied in agriculture and aquaculture industries to improve important production traits. In our previous studies, we produced the F1 hybrids with high heterosis in growth by crossing the bay scallops with the Peruvian scallops and selected a new strain, Bohai Red, from the F1 hybrids. In this study, we selected another new strain from the backcross (BC1) of the F1 hybrids with bay scallops. The base cohort (G0) was size-selected from the BC1, and the G1, G2, G3 and G4 cohorts were produced with size-selected brood stocks from the G0, G1, G2 and G3 cohorts respectively. Our results showed that average shell height, shell length, shell width and whole body weight of the G4 cohort were increased by 16.8%, 16.8%, 11.5% and 43.6%, respectively, compared with the unselected control group of bay scallop. This new strain has now become one of the major cultured Argopecten scallops in northern China waters and was later named QN-2.
Development of a dietary fiber gel for calorie-reduced foods (1997)

Development and properties of a new generation fat replacer based on fibre gels are described. The product (called Z-Trim due to its zero calorie value) provides an aqueous gel fibre structure without taste and imparts a smooth texture to foods such as hamburgers, delicatessen meats, cheeses and baked foods. The aqueous gel fibres are obtained from dietary fibre by complete disintegration of their cellular structure using a multistage alkaline shear process. The product can be used to obtain large reductions in calories as well as providing a source of dietary fibre.
Constraint-based routing for ad-hoc networks (2003)

Future large-scale networks, such as sensor networks, will consist of hundreds and even thousands of wirelessly connected sensor and actuator nodes. The nodes are typically highly resource-constrained (processor, memory, and power), have limited communication range, and are prone to failure. Furthermore, there is no global information about the exact location and connectivity of the nodes. Consequently, the explicit consideration of network and task constraints and objectives will be an important part of routing algorithms for these networks. We present a distributed constraint-based routing approach that represents destination conditions as well as routing constraints and objectives explicitly. We further present an efficient routing algorithm, CB-LRTA*, that extends traditional Learning Real-Time A* (LRTA*) with back-propagation. We evaluate CB-LRTA* using simulation and demonstrate that it improves convergence to the optimal route over LRTA*.