gebhart/patrepeval huggingface dataset:
Accelerating Lattice Boltzmann Fluid Flow Simulations Using Graphics Processors (2009)

Lattice Boltzmann methods (LBM) are used for the computational simulation of Newtonian fluid dynamics. LBM-based simulations are readily parallelizable; they have been implemented on general-purpose processors, field-programmable gate arrays (FPGAs), and graphics processing units (GPUs). Of the three methods, the GPU implementations achieved the highest simulation performance per chip. With memory bandwidth of up to 141 GB/s and a theoretical maximum floating point performance of over 600 GFLOPS, CUDA-ready GPUs from NVIDIA provide an attractive platform for a wide range of scientific simulations, including LBM. This paper improves upon prior single-precision GPU LBM results for the D3Q19 model by increasing GPU multiprocessor occupancy, resulting in an increase in maximum performance by 20%, and by introducing a space-efficient storage method which reduces GPU RAM requirements by 50% at a slight detriment to performance. Both GPU implementations are over 28 times faster than a single-precision quad-core CPU version utilizing OpenMP.
Experimental demonstration of impulse-equivalent time-domain optical memory (1996)

We demonstrate the impulse-equivalent approach [Opt. Lett. 21, 833 (1996)] to time-domain storage of optical data. Using the 128-bit real Huffman-Ackroyd code as the write-read sequences, we have successfully stored a 42-micros-long stream containing 420 bits of data in a 40-MHz spectral channel in a Eu(3+):Y(2)SiO(5) crystal. The stored data were repeatedly recalled as many as eight times with high signal f idelity, showing no measurable sidelobe-induced noise. Data retrieval with the use of mismatched write-read pulses was also examined, and implications of the results for data encryption are discussed.
Unsupervised Monocular Depth Estimation Method Based on Uncertainty Analysis and Retinex Algorithm (2020)

Depth estimation of a single image presents a classic problem for computer vision, and is important for the 3D reconstruction of scenes, augmented reality, and object detection. At present, most researchers are beginning to focus on unsupervised monocular depth estimation. This paper proposes solutions to the current depth estimation problem. These solutions include a monocular depth estimation method based on uncertainty analysis, which solves the problem in which a neural network has strong expressive ability but cannot evaluate the reliability of an output result. In addition, this paper proposes a photometric loss function based on the Retinex algorithm, which solves the problem of pulling around pixels due to the presence of moving objects. We objectively compare our method to current mainstream monocular depth estimation methods and obtain satisfactory results.
PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications (2017)

Although valproic acid (VPA), has been shown to induce neuronal differentiation of neural stem cells (NSCs), the underlying mechanisms remain poorly understood. Here we investigated if and how mammalian target of rapamycin (mTOR) signaling is involved in the neuronal differentiation of VPA-induced NSCs. Our data demonstrated that mTOR activation not only promoted but also was necessary for the neuronal differentiation of NSCs induced by VPA. We further found that inhibition of mTOR signaling blocked demethylation of neuron-specific gene neurogenin 1 (Ngn1) regulatory element in induced cells. These are correlated with the significant alterations of passive DNA demethylation and the active DNA demethylation pathway in the Ngn1 promoter, but not the suppression of lysine-specific histone methylation and acetylation in the promoter region of Ngn1. These findings highlight a potentially important role for mTOR signaling, by working together with DNA demethylation, to influence the fate of NSCs via regulating the expression of Ngn1 in VPA-induced neuronal differentiation of NSCs.
Medicinal Chemistry of Quinolines As Emerging Anti-inflammatory Agents: An Overview (2013)

Quinoline-based small molecules have been explored and being developed as anti-inflammatory agents targeting several pharmacological targets namely Phosphodiesterase 4 (PDE4), Transient Receptor Potential Vanilloid 1 (TRPV1), TNF-α converting enzyme (TACE) and Cyclooxygenase (COX). Efforts on Structure Activity Relationship (SAR) studies revealed that the pharmacological activities and target specificities of these quinoline derivatives were mainly dependent on the nature and position of substituent(s) present on the quinoline ring. For example, quinolines having carboxamide moiety displayed TRPV1 antagonism whereas that with carboxylic acid showed COX-inhibition. Similarly, quinolines possessing aniline moiety at C-4, aryl group at C-8 and oxazole ring at C-5 showed PDE4 inhibition. These quinoline derivatives were synthesized by using various synthetic approaches like Pd-mediated C-C (e.g. Suzuki, Sonogashira type coupling etc.) or C-N (the Buchwald-Hartwig type coupling) or C-S bond formation, AlCl₃ induced C-C bond formation, traditional amide bond formation or amination, formation of ether linkage or additional heterocyclic rings. All these efforts resulted in the discovery of several quinoline-based anti-inflammatory agents for the potential treatment of acute as well as chronic inflammatory diseases.
Interchain Interactions Mediated by Br Adsorbates in Arrays of Metal–Organic Hybrid Chains on Ag(111) (2011)

Interchain interactions in arrays of metal–organic hybrid chains were studied using scanning tunneling microscopy and ab initio calculations. The array of hybrid chains having a Ag–anthryl biradical were self-assembled by catalytic scission of Br–C bonds in 9,10-dibromoanthracene on Ag(111). An atomic model for the observed chain structures was proposed. Ag atoms in chains were alternatingly located at hollow sites, making slightly zigzaging structures. Between the hybrid chains, Br atoms located at hollow sites to form Br···H intermolecular bonds. Anthryl biradicals had two different apparent heights; this was explained by considering Br···H intermolecular bonds and intrachain steric repulsion. When a hybrid chain was laterally moved by manipulation techniques, Br adsorbates moved together with the chain, implying that they are stabilized by Br···H intermolecular bonds.
Residual Stresses and Thermo-Mechanical Behavior of Metal-Matrix Composites (1984)

A plastic flow code was used to calculate microscopic stress- temperature histories in metal-matrix composites during a cooling and reheating cycle. Stress results are given for graphite/aluminum, tungsten/aluminum and silicon carbide aluminum composites. For the graphite/aluminum material a parametric study was carried out on the effect of variations in various fiber properties on the calculated stresses. A computer code is presented for calculating the thermo elastic properties of cross-plied laminates from those of the individual plies on from the fiber and matrix properties appropriate to each ply. Modifications to a code developed previously for computing the properties of a unidirectionally reinforced composite from those of the fiber and matrix components are described. A two dimensional Fourier series solution is presented for determining the stresses and deformation of plates subjected to an arbitrary, transverse temperature distribution. Numerical results are given for several temperature profiles, including a discontinuous step-function distribution.
Hepatic Glycogen Staining (2001)

Hepatic glycogen stores have long been known to decrease with starvation, trauma, acute stress, and shock. In this study, hepatic tissue was examined in 122 decedents ranging in age from 1 to 88 years who died of a variety of causes. Hepatic tissue was stained for glycogen/carbohydrates using the Best's carmine and/or period acid-Schiff (PAS)-alcian blue methods in 121 cases. The liver samples were evaluated for amount of staining, staining around hepatic injuries (if present), and presence of histologic abnormalities. Prominence of staining was decreased with increasing survival times after injury (P=.0001) and increasing postmortem interval. Staining along the edges of hepatic injuries was decreased in antemortem injuries but not in postmortem-induced injuries (P<.0001). If used in conjunction with circumstantial and autopsy information, hepatic glycogen/carbohydrate staining using the Best's carmine and PAS-alcian blue methods could greatly aid in the determination of injury survival times and the vital nature of questionable injuries in child deaths and other cases.
Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia (2009)

Quantitative evaluation of respiratory sinus arrhythmia (RSA) may provide important information in clinical practice of anesthesia and postoperative care. In this paper, we apply a point process method to assess dynamic RSA during propofol general anesthesia. Specifically, an inverse Gaussian probability distribution is used to model the heartbeat interval, whereas the instantaneous mean is identified by a linear or bilinear bivariate regression on the previous R-R intervals and respiratory measures. The estimated second-order bilinear interaction allows us to evaluate the nonlinear component of the RSA. The instantaneous RSA gain and phase can be estimated with an adaptive point process filter. The algorithm's ability to track non-stationary dynamics is demonstrated using one clinical recording. Our proposed statistical indices provide a valuable quantitative assessment of instantaneous cardiorespiratory control and heart rate variability (HRV) during general anesthesia.
Powering Intel Pentium 4 Generation Processors (2001)

Power delivery design methodology of Intel@ Pentium54 processors is presented, including loadline specification, voltage regulator design, and decoupling on motherboard and package. The results of simulation analyses are verified with measured data. I. Introduction As microprocessors continue to follow Moore's Law by increasing their computing power and speed, delivering power to microprocessors becomes increasingly challenging. The compounded effect of increased current (I), increased current slew rate (dl/dt), and reduced voltage tolerance window (LIP') results in exponential design difficulty. To design an eficient and cost-effective power delivery solution to power processors, one needs to follow a comprehensive and rigorous design approach, which takes into account different design aspects from the system motherboard, processor socketlpackaging, and CPU behaviors. This paper shows the power delivery design methodology for processors, including the CPU voltage specifications, voltage regulator design, and decoupling strategy. To illustrate the usefulness and the accuracy of the design methodology, simulation results of the design recommendation are compared to measurement data.
Performance Evaluation of Received Signal Strength Based Hard Handover for UTRAN LTE (2007)

This paper evaluates the hard handover performance for UTRAN LTE system. The focus is on the impact that received signal strength based hard handover algorithm have on the system performance measured in terms of number of handovers, time between two consecutive handovers and uplink SINR for a user about to experience a handover. A handover algorithm based on received signal strength measurements has been designed and implemented in a dynamic system level simulator and has been studied for different parameter sets in a 3GPP UTRAN LTE recommended simulation scenario. The results suggest that a downlink measurement bandwidth of 1.25 MHz and a handover margin of 2 dB to 6 dB are the parameters that will lead to the best compromise between average number of handovers and average uplink SINR for user speeds of 3 kmph to 120 kmph.
Performing O'Neill: conversations with actors and directors (2001)

In Performing O'Neill, Yvonne Shafer talks with the most important actors and directors who interpreted O'Neill in the 20th century: Jason Robards, Jane Alexander, Fritz Weaver, James Earle Jones, Theresa Wright, Gloria Foster, Ted Mann, and Arvin Brown, to name just a few. Actors like Robards talk about their first encounters with the master and their interpretations of roles like Hickey in Iceman Cometh and James Tyrone in Long Day's Journey Into Night. Directors talk about the challenges they face in bringing O'Neill's dark and compelling vision of American life to the stage and making it relevant for audiences in the 21st century. The work is a lively collection of interviews in the Paris Review tradition constructed by one of the foremost O'Neill scholars writing today.
Cell-Based Variable-Gain Amplifiers With Accurate dB-Linear Characteristic in 0.18 µm CMOS Technology (2014)

A simple and robust “cell-based” method is presented for the design of variable-gain amplifiers (VGAs). The proposed unit cell utilizes a unique gain compensation method and achieves accurate dB-linear characteristic across a wide tuning range with low power consumption and wide bandwidth. Several such highly dB-linear unit cells can be cascaded to provide the required gain range for a VGA. To prove the concept, single-cell, 5-cell, 10-cell and 15-cell reconfigurable VGAs were fabricated in a standard 0.18 μm CMOS technology. The measurement results show that the 10-cell VGA achieves a gain range of 38.6 dB with less than 0.19 dB gain error. The 15-cell VGA can either be used as reconfigurable VGA for analog control voltage or tunable PGA for digital control stream, with the flexibility of scaling gain range, gain error/step and power consumption. For the VGA at highest gain setting, it consumes 1.12 mW and achieves a gain range of 56 dB, gain error less than 0.3 dB.
Agile and Resilient Insect-Scale Robot (2018)

A key challenge in bioinspired insect-scale running robots is to make them both agile and resilient. In this study, we develop a dielectric elastomer actuated soft robot that mimics inchworms. We use an elastomer to make the soft body, a stretchable dielectric to provide electrostatic actuation of high power density, and multizone actuation to achieve ratcheting locomotion. We fabricate the body, muscles, and feet in a single piece, with no internal open space. The robot runs four times its body length per second and turns at a radius about three times its body length in 0.3 s. The robot survives compression 30,000 times its own weight and survives collision with a rigid surface at a speed of 30 m/s. The robot can climb a slope of 30°. Walking on a horizontal plane, the robot carries a payload four times its own weight. The robot can operate on land, underwater, and in vacuum. The simplicity in design and fabrication will enable the robot to serve as a model system to investigate insect-scale actuation and locomotion, as well as the social behavior of swarms of robots. The robot also provides a platform to integrate wireless charging, mobile communication, and stretchable electronics.
Low Cost Localisation for Agricultural Robotics (2013)

This paper presents a pose estimation approach that is resilient to typical sensor failure and suitable for low cost agricultural robots. Guiding large agricultural machinery with highly accurate GPS/INS systems has become standard practice, however these systems are inappropriate for smaller, lower-cost robots. Our positioning system estimates pose by fusing data from a low-cost global positioning sensor, low-cost inertial sensors and a new technique for vision-based row tracking. The results first demonstrate that our positioning system will accurately guide a robot to perform a coverage task across a 6 hectare field. The results then demonstrate that our vision-based row tracking algorithm improves the performance of the positioning system despite long periods of precision correction signal dropout and intermittent dropouts of the entire GPS sensor.
Inhalation of α-gal/sialic Acid Liposomes: A Novel Approach for Inhibition of Influenza Virus infection? (2016)

Effective inhibition of influenza virus infection in symptomatic patients may be feasible by inhalation of aerosol-containing liposomes presenting α-gal epitopes and sialic acid epitopes. The virus binds to sialic acid epitopes and the natural anti-Gal antibody binds to α-gal epitopes on the liposomes and activates the complement system to generate chemotactic peptides that recruit macrophages. These macrophages bind and internalize via their Fc receptors, anti-Gal-coated liposomes and the influenza virus bound to them, process the viral antigens and transport them to the regional lymph nodes for eliciting a rapid, protective immune response that prevents progression of the virus infection.
Heart rate reduction--a mechanism of benefit? (1987)

Heart rate reduction—a mechanism of benefit? Get access J. Kjekshus J. Kjekshus Department of Medicine, Baerum HospitalSandvika, 1316 Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 8, Issue suppl_L, December 1987, Pages 115–122, https://doi.org/10.1093/eurheartj/8.suppl_L.115 Published: 01 December 1987
Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens (2012)

No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, a P. falciparum-specific protein expressed in merozoites, is efficiently targeted by broadly-neutralizing, vaccine-induced antibodies. Here we show that antibodies against PfRH5 efficiently inhibit the in vitro growth of short-term-adapted parasite isolates from Cambodia, and that the EC(50) values of antigen-specific antibodies against PfRH5 are lower than those against PfAMA1. Since antibody responses elicited by multiple antigens are speculated to improve the efficacy of blood-stage vaccines, we conducted detailed assessments of parasite growth inhibition by antibodies against PfRH5 in combination with antibodies against seven other merozoite antigens. We found that antibodies against PfRH5 act synergistically with antibodies against certain other merozoite antigens, most notably with antibodies against other erythrocyte-binding antigens such as PfRH4, to inhibit the growth of a homologous P. falciparum clone. A combination of antibodies against PfRH4 and basigin, the erythrocyte receptor for PfRH5, also potently inhibited parasite growth. This methodology provides the first quantitative evidence that polyclonal vaccine-induced antibodies can act synergistically against P. falciparum antigens and should help to guide the rational development of future multi-antigen vaccines.
Adaptive replication control based on consensus (2008)

This paper presents a meta protocol that allows the dynamic replacement of replication control protocols in replicated databases. The meta protocol is motivated by the diversity of concurrency control and replication control protocols that implement different transaction isolation levels. The replacement of protocols allows applications to dynamically adapt themselves to consistency and data access latency requirements. Such kind of adaptivity is important in mobile systems, where weaker consistency levels are acceptable when nodes are disconnected from a network, but stronger levels may be required when nodes are connected to each other. The paper defines three properties that meta protocol executions have to enforce and specifies a protocol that satisfies these properties. The protocol is based on a transaction execution model, uniform reliable broadcast and uniform consensus. Finally, we outline a dynamic adaptable architecture that is being implemented that includes the meta protocol and that makes use of an aspect oriented framework.
Estimation of in-band distortion in digital communication system (2005)

A generalized approach for estimating in-band distortion spectrum when a wireless communication signal is processed by a nonlinear amplifier is presented. The output spectrum is represented as the sum of uncorrelated components using Gram-Schmidt orthogonalization without any restriction on the statistical properties of the input signals. The analysis allows the accurate estimation of in-band distortion and hence the effective SNR, Rho and EVM of wireless communication systems. The approach is verified by measurements of in-band distortion using feed-forward cancellation.
A Rho-associated protein kinase: differentially distributed in limbal and corneal epithelia. (1998)

The increased expression of a protein identified as ROCK-I from cDNA analyses is associated with rabbit corneal epithelial differentiation and transition from the limbal to corneal surface. Therefore, a RhoA signaling pathway is likely to be associated with corneal epithelial differentiation (maturation). A close homology among the cDNA sequences of rabbit, mouse, rat, and human ROCK-I indicates that this RhoA-associated kinase is a well-conserved protein.
Virtual prototyping of cellular phones (1999)

Software prototyping offers a fast, flexible and cost-effective alternative to physical prototyping during the analysis and design stages of commercial electronic products. This paper describes a software platform implemented to facilitate the virtual prototyping of cellular phone models at the analysis and design stages. In order to discuss the application of the platform, an example of a basic cellular phone is considered. The features and functions of a standard cellular phone have been implemented as primitives in a Parts library, and its behavioural characteristics can be dynamically simulated via script files. The prototyping platform provides modularity, and requires minimal implementation effort to accommodate new cellular phone model specifications. In addition, the platform is able to demonstrate the practical usefulness of software prototyping in reducing the complexity of product analysis and design. Copyright © 1999 John Wiley & Sons, Ltd.
Living in a browning environment: Effects on <i>Daphnia</i>’s growth and fatty acid pattern (2018)

Abstract To assess whether different concentrations of dissolved organic matter (DOM) rich in humic substances (HS) affect growth rates, reproduction and fatty acids (FA) composition of Daphnia pulex under bright light, we performed microcosms controlled laboratory trials. Experiments were run using two microalgae as food source, Cryptomonas erosa and Scenedesmus acutus at four DOM additions (0 mg C L −1 , 15 mg C L −1 , 30 mg C L −1 , and 60 mg C L −1 ) under unlimited food concentrations. Results show that daphnids’ growth rates were significantly higher feeding on Scenedesmus than on Cryptomonas , but were not significantly affected by the HS‐rich‐DOM concentrations. In contrast, clutch sizes increased with increasing concentrations of HS‐rich‐DOM, with nonsignificant differences between both food treatments. As expected, FA in daphnids were mainly impacted by the food. Irrespectively of food, the content of total FA and especially saturated FA were lower in the treatments with the highest addition of HS‐rich‐DOM. In the Scenedesmus trial, certain highly unsaturated FA (HUFA) susceptible to UV degradation could only be observed in the treatments with higher concentrations of HS‐rich‐DOM (e.g., eicosapentaenoic acid [EPA] and arachidonic acid [ARA] at 30, and EPA, ARA and docosahexaenoic acid [DHA] only at 60 mg L −1 ). In the Cryptomonas trial, DHA levels increased with increasing concentrations of HS‐rich‐DOM. Our results show that FA mediated food quality impacted how HS‐rich‐DOM affected Daphnias ’ growth. As the high dietary content in HUFA probably caused daphnids lower growth rates under UV exposure, there seems to be a trade‐off between beneficial and potential detrimental effects of feeding on a diet rich in HUFA.