gebhart/patrepeval huggingface dataset:
Abstract 1597: Expression of caPCNA and antineoplastic action of caPeptides in pancreatic cancer cells (2010)

Abstract Our laboratory previously reported the identification of an acidic isoform of proliferating cell nuclear antigen (caPCNA) in various cancer cells, which appears to be associated, at least in part, with malignant transformation of cells. The current studies show the expression of caPCNA in BXPC-3, Paca-2 and Capan-1 pancreatic cancer cells. Since Proliferating Cell Nuclear Antigen (PCNA) is involved in DNA replication and repair in prokaryote and eukaryote cells, we hypothesize that caPCNA is likely to perform similar functions specifically in cancer cells. Antibodies developed against caPCNA showed growth inhibition activity in cancer cells suggesting caPCNA is related to the proliferation of malignant cells. In order to begin to understand the function of caPCNA in cellular malignant transformation, we have investigated the interaction of caPCNA with its binding partners including flap structure-specific endonuclease 1(Fen-1) and xeroderma pimentosum complementation group G (XPG). We have identified an amino acid domain sequence that confers the cancer cell specificity of caPCNA. In the course of our studies we synthesized small caPCNA related peptides (caPeptides) derived from this sequence that promote cancer cell cytotoxicity. caPeptides have the potential ability to compete with several cellular proteins that participate in DNA replication, repair, cell cycle control, transcription, and chromosomal recombination for their naturally occurring binding site on caPCNA and block binding of full length caPCNA to these proteins. The disruption of the interaction between caPCNA and its binding proteins prevents cancer cellular functions (vital cellular machinery) that recruit caPCNA and therefore may lead caPCNA-derived peptides to be cytotoxic by themselves or in combination with cancer chemotherapeutic drugs. These peptides, either alone or in combination with other anticancer agents are potentially useful cancer chemotherapeutics or augmentors of the pharmacodynamic effect of specific anti-cancer chemotherapeutics. Our results show that these peptides demonstrate promising growth inhibition and cytotoxicity in pancreatic cancer cells. Considering that pancreatic cancer is well known for its high mortality rate due to its chemotherapy ineffectiveness our studies render further investigations on the action of caPCNA and the anti-neoplastic mechanism of the peptides in pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1597.
High performance topological insulator nanowire field-effect transistors (2013)

We show experimentally that single-crystal nanowires of the topological insulator Bi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> can be used as the conduction channel in high-performance field effect transistor, a basic circuit building block. The current-voltage characteristics are superior to many of those reported for semiconductor nanowire transistors. The metallic electron transport at the surface with good mobility can be effectively separated from the bulk conduction and adjusted by field effect at a small gate voltage. These properties open up a many potential applications in nanoelectronics and spintronics.
Novel pyroelectric sensor materials (1998)

Ceramic compositions of barium strontium titanium oxide (BSTO) have been formulated for applications as pyroelectric sensor materials. The material has been fabricated in tape-cast and thin film forms. In general, the materials demonstrated high pyroelectric coefficients (p) accompanied with low dielectric constant and low dissipation factor. The compositions of the tape-cast and thin film specimens examined in this paper include a well-known commercially adopted Ba<sub>0.64</sub>Sr<sub>0.36</sub>TiO<sub>3</sub> as well as a composition suggested in the literature, and a patented composition with the addition of MgO to BSTO is investigated. Doping BSTO with MgO has been shown to reduce the dielectric constant and loss tangent (over a very wide frequency range from 100 Hz-10 GHz) of the material and thereby increase the pyroelectric figure of merit. This article will discuss the processing, material characterization, pyroelectric coefficient, and pyroelectric figure-of-merit of the above mentioned BSTO compositions.
A monoclonal antibody to a cross-reactive idiotype on cationic human anti-DNA antibodies expressing lambda light chains: a new reagent to identify a potentially differential pathogenic subset. (1987)

Anti-double-stranded DNA antibodies are commonly found in the serum of patients with systemic lupus erythematosus (SLE). They are a heterogeneous group of antibodies thought to differ in pathogenicity. The degree of heterogeneity and the structural correlates of pathogenicity, however, remain poorly defined. To address these questions we have been generating anti-idiotypic antibodies to the anti-DNA antibodies found in the serum of SLE patients. In this paper we report the generation and characterization of a new murine monoclonal anti-idiotype, 8.12, that recognizes a subset of anti-DNA antibodies that is present in serum of approximately 50% of patients with SLE. The 8.12 anti-idiotype recognizes uniquely cationic anti-DNA antibodies, all of which express lambda light chains. In murine models of SLE, it has been suggested that cationic anti-DNA antibodies are preferentially deposited in the kidney. It may be, therefore, that 8.12 recognizes a subset of anti-DNA antibodies of particular pathogenic significance.
High speed performance of III-nitride laser diode grown on (2021) semipolar plane for visible light communication (2016)

III-nitride light emitting diodes (LEDs) have been used for many applications covering the spectrum of ultraviolet (UV) to visible light (VL). Despite of significant improvements on solid-state lighting, LEDs still suffer significant efficiency loss at high carrier density, commonly referred as "efficiency droop" [1]. However, compared to LEDs, laser diodes (LDs) have higher power per chip and the absence of efficiency droop above lasing threshold. In addition to the advantage of solid-state lighting, LDs can be modulated at much higher frequency than LEDs.
Alcohol-, Diol-, and Carbohydrate-Substituted Indenoisoquinolines as Topoisomerase I Inhibitors: Investigating the Relationships Involving Stereochemistry, Hydrogen Bonding, and Biological Activity (2011)

The DNA-relaxing enzyme topoisomerase I (Top1) can be inhibited by heterocyclic compounds such as indolocarbazoles and indenoisoquinolines. Carbohydrate and hydroxyl-containing side chains are essential for the biological activity of indolocarbazoles. The current study investigated how similar functionalities could be "translated" to the indenoisoquinoline system and how stereochemistry and hydrogen bonding affect biological activity. Herein is described the preparation and assay of indenoisoquinolines substituted with short-chain alcohols, diols, and carbohydrates. Several compounds (including those derived from sugars) display potent Top1 poisoning and antiproliferative activities. The Top1 poisoning activity of diol-substituted indenoisoquinolines is dependent upon stereochemistry. Although the effect is striking, molecular modeling and docking studies do not indicate any reason for the difference in activity due to similar calculated interactions between the ligand and Top1-DNA complex and ambiguity about the binding mode. A stereochemical dependence was also observed for carbohydrate-derived indenoisoquinolines. Although similar trends were observed in other classes of Top1 inhibitors, the exact nature of this effect has yet to be elucidated.
Flying-Adder on-chip frequency synthesis architecture (2008)

The construction of on-chip clock circuitry has great impact on both system performance and chip implementation cost. Among the many aspects of the clock circuitry, the most important one is its capability of producing frequencies. Flying-Adder frequency synthesis architecture, one of the latest developments in clock generation circuitry, is such a circuit-level enabler which can help circuit designers and system engineers to create better-performance and/or lower-cost systems. With this technique, many system and software level issues can be investigated from new directions. Compared to the conventional techniques, this method is capable of generating much more frequencies. Furthermore, it provides great controllability to software so that software programmers have the flexibility of creating novel approaches to differentiate their products from the competitors’. In this tutorial, the Flying-Adder architecture will be first introduced. Then, several real systems are used to demonstrate the power of this new frequency synthesis technique.
Automated dynamic Young's modulus and loss factor measuremeats (1980)

A progressive wave apparatus featuring an automated data processor is described. The apparatus accurately determines the propagation constants of an extensional acoustic wave by exciting one end of a strip of material while the other end is suspended under constant tension. The apparatus is capable of making measurements in the frequency range of 100 Hz to 40 kHz, depending on the extensional wave velocity and attenuation in the material. As illustrations of the technique, measurements were made on several rubber compounds of different polymer type and compounding ingredients. Extensional sound speed, attenuation, modulus, and loss factor were determined over a frequency range of 1–10 kHz and a temperature range of 4°–47°C. Applying the time-temperature superposition principle to the data, master curves were constructed and WLF shift constants were determined. The apparatus was found to be a fast and reliable method to determine the dynamic viscoelastic constants.
Policy management for ENUM system enabling privacy and security (2009)

ENUM (Telephone Number Mapping) is a key enabler in the convergence between IP-based networks and the traditional PSTNs that may result in additional complexity in commercial relationships and regulation of the telecommunications sector. In particular, the current ENUM may significantly increase the risk of unscrupulous use of the information managed (e.g., public user identifiers and user/service reachability). The aim of this article is to describe a new functional reference model for ENUM, and provide some new requirements that enable user privacy and security.
Probiotic Cocktail Identified by Microbial Network Analysis Inhibits Growth, Virulence Gene Expression, and Host Cell Colonization of Vancomycin-Resistant Enterococci (2020)

The prevalence of vancomycin resistant enterococcus (VRE) carrier-state has been increasing in patients of intensive care unit and it would be a public health threat. Different research groups conducted decolonizing VRE with probiotic and the results were controversial. Therefore, a systemic approach to search for the probiotic species capable of decolonizing VRE is necessary. Thus, VRE was co-cultured with ten probiotic species. The fluctuations of each bacterial population were analyzed by 16S rRNA sequencing. Microbial network analysis (MNA) was exploited to identify the most critical species in inhibiting the VRE population. The MNA-selected probiotic cocktail was then validated for its efficacy in inhibiting VRE, decolonizing VRE from Caco-2 cells via three approaches: exclusion, competition, and displacement. Finally, the expression of VRE virulence genes after co-incubation with the probiotic cocktail were analyzed with quantitative real-time PCR (qRT-PCR). The MNA-selected probiotic cocktail includes <i>Bacillus</i> <i>coagulans</i>, <i>Lactobacillus</i> <i>rhamnosus</i> GG, <i>Lactobacillus</i> <i>reuteri</i>, and <i>Lactobacillus acidophilus</i>. This probiotic combination significantly reduces the population of co-cultured VRE and prevents VRE from binding to Caco-2 cells by down-regulating several host-adhesion genes of VRE. Our results suggested the potential of this four-strain probiotic cocktail in clinical application for the decolonization of VRE in human gut.
Giant voltage manipulation of MgO-based magnetic tunnel junctions via localized anisotropic strain: A potential pathway to ultra-energy-efficient memory technology (2016)

Voltage control of magnetization via strain in piezoelectric/magnetostrictive systems is a promising mechanism to implement energy-efficient straintronic memory devices. Here, we demonstrate giant voltage manipulation of MgO magnetic tunnel junctions (MTJ) on a Pb(Mg1/3Nb2/3)0.7Ti0.3O3 piezoelectric substrate with (001) orientation. It is found that the magnetic easy axis, switching field, and the tunnel magnetoresistance (TMR) of the MTJ can be efficiently controlled by strain from the underlying piezoelectric layer upon the application of a gate voltage. Repeatable voltage controlled MTJ toggling between high/low-resistance states is demonstrated. More importantly, instead of relying on the intrinsic anisotropy of the piezoelectric substrate to generate the required strain, we utilize anisotropic strain produced using a local gating scheme, which is scalable and amenable to practical memory applications. Additionally, the adoption of crystalline MgO-based MTJ on piezoelectric layer lends itself to high TMR in the strain-mediated MRAM devices.
<i>In Situ</i> Evaluation of Paenibacillus alvei in Reducing Carriage of Salmonella enterica Serovar Newport on Whole Tomato Plants (2014)

ABSTRACT Recently, tomatoes have been implicated as a primary vehicle in food-borne outbreaks of Salmonella enterica serovar Newport and other Salmonella serovars. Long-term intervention measures to reduce Salmonella prevalence on tomatoes remain elusive for growing and postharvest environments. A naturally occurring bacterium identified by 16S rRNA gene sequencing as Paenibacillus alvei was isolated epiphytically from plants native to the Virginia Eastern Shore tomato-growing region. After initial antimicrobial activity screening against Salmonella and 10 other bacterial pathogens associated with the human food supply, strain TS-15 was further used to challenge an attenuated strain of S . Newport on inoculated fruits, leaves, and blossoms of tomato plants in an insect-screened high tunnel with a split-plot design. Survival of Salmonella after inoculation was measured for groups with and those without the antagonist at days 0, 1, 2, and 3 and either day 5 for blossoms or day 6 for fruits and leaves. Strain TS-15 exhibited broad-range antimicrobial activity against both major food-borne pathogens and major bacterial phytopathogens of tomato. After P. alvei strain TS-15 was applied onto the fruits, leaves, and blossoms of tomato plants, the concentration of S . Newport declined significantly ( P ≤ 0.05) compared with controls. Astonishingly, >90% of the plants had no detectable levels of Salmonella by day 5 for blossoms. The naturally occurring antagonist strain TS-15 is highly effective in reducing the carriage of Salmonella Newport on whole tomato plants. The application of P. alvei strain TS-15 is a promising approach for reducing the risk of Salmonella contamination during tomato production.
Pattern recognition tool to detect reconfigurable patterns in MPEG4 video processing (2002)

Current approaches towards building a reconfigurable processor are targeted towards general purpose computing or a limited range of media specific applications and are not specifically tuned for mobile multimedia applications. The increasing demand for mobile multimedia processing with stringent constraints for low power, low chip area and high flexibility at both the encoder and decoder naturally demand the design and development of a dynamically reconfigurable multimedia processor. We have performed a detailed complexity analysis of the MPEG-4 video coding mode which has illustrated the potential for reconfigurable computing. We have recently proposed a methodology for designing a reconfigurable media processor. This involves the design of a parser that identifies data/control flow graphs generated from the input assembly code of an UltraSPARC V-9 architecture; recurring pattern analyzer that uses a clustering based approach to identify specific sequences of operations that can potentially be implemented in hardware; and finally a count of such modules at every level of granularity with the associated weights based on the complexity of computation and data transfers used by partitioner and router. In this paper we then propose the design of the parser and pattern recognizer with results for detecting the reconfigurable patterns in MPEG4.
Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48 (2013)

A histone-binding protein that declines with age in the human dentate gyrus can reverse age-related memory deficits in mice.
CMOS terahertz metamaterial based 64 × 64 bolometric detector arrays (2017)

We present two terahertz detectors composed of microbolometer sensors (vanadium oxide and silicon pn diode) and metamaterial absorbers monolithically integrated into a complementary metal oxide semiconductor (CMOS) process. The metamaterial absorbers were created using the metal-dielectric-metal layers of a commercial CMOS technology resulting in low-cost terahertz detectors. The scalability of this technology was used to form a 64 × 64 pixel terahertz focal plane array.
Machine Learning Based Hydrogen Electrolyzer Control Strategy for Solar Power Output and Battery State of Charge Regulation (2021)

Photovoltaic (PV) power is an extensively used renewable energy resource, but its intermittent nature affects the power supply quality as it results in issues such as frequency aberrations and voltage variations. Battery Energy Storage Systems (BESS) are utilized to smooth out and resolve the fluctuation issues. However, a control method is required for BESS charging level regulation to prevent the need for larger storage systems and to extend its operational life through controlled charging/discharging. This paper proposes a novel solar power and battery state of charge (SoC) control technique through the incorporation of hydrogen electrolyzer (HE) fuel cell system and BESS. A machine learning based controller (MLC) is designed for dynamic control of the HE output to allow the dispatching of firmed PV power with controlled battery charging/discharging. The MLC takes the fluctuating power and various battery parameters as inputs and intelligently controls the HE output while obeying the imposed constraints. Results conclude that the MLC greatly reduces the PV power fluctuations and a comparison between the fuzzy logic control for SoC regulation shows that the MLC has better SoC management capability. The proposed methodology promotes the integration of hydrogen into the energy mix as a means for providing controlled solar power.
The pi-Cell: A Fast Liquid-Crystal Optical-Switching Device (1984)

Abstract A new approach is given for obtaining fast electro-optical response and good angular-viewing characteristics in a liquid-crystal variable-retardation device. The improved characteristics make the new device well suited for use in field-sequential color systems.
Characterization Of High Performance Silicide Schottky Photodiodes (1989)

Schottky barrier diodes made from platinum silicide are outstanding candidates for staring imagery in the MWIR band. This use was first suggested by Shepherd et. al. in 1974 who reported results on small arrays. The technology has advanced rapidly and large, two dimensional arrays of staring Schottky diodes are presently available. The detectors are fabricated on high quality, VLSI grade silicon substrates. Two dimensional arrays of these diodes have extremely high uniformity of optical responsivity. This fact allows for simple application of non-uniformity correction algorithms which give MRT's of less than 0.05K. The rapid advancement of PtSi as an infrared imaging technology is in a large part due to the advanced state of silicon substrate technology.
Chemical Engineering of Aerogel Morphology Formed under Nonsupercritical Conditions for Thermal Insulation (2000)

Aerogels are among the best thermal insulating materials known. This property arises from the fact that in these materials the gaseous phase, which may occupy over 90% of the volume, is compartmentalized to a size smaller than the mean free path of air, thus severely restricting its thermal conductivity. The solid framework, which compartmentalizes the gaseous space with a minimum amount of solid, is fragile and thus must be assembled in a liquid phase that is later extracted under supercritical conditions to create the porosity. This requirement for supercritical liquid extraction, to eliminate surface tension, makes the process costly and often unsuitable for large-scale commercial applications. By computer-designed experiments, an investigation was conducted in order to produce aerogels under non-supercritical conditions. Silica aerogels having approximately 80% porosity were produced under atmospheric conditions. Moreover, the resulting pore morphology is more restrictive to thermal conductivity than that produced under supercritical conditions. This aerogel was also transformed into a micronized powder form without affecting its pore morphology, by interruption of its gelling state, thus eliminating solid-state grinding. In this paper the design of this aerogel, its pore morphology, micronization, hydrophobizing, and its use in thermal insulation are discussed.
Discriminative Techniques for Keyframe Selection (2005)

A convenient representation of a video segment is a single "keyframe". Keyframes are widely used in applications such as non-linear browsing and video editing. With existing methods of keyframe selection, similar video segments result in very similar keyframes, with the drawback that actual differences between the segments may be obscured. We present methods for keyframe selection based on two criteria: capturing the similarity to the represented segment, and preserving the differences from other segment keyframes, so that different segments will have visually distinct representations. We present two discriminative keyframe selection methods, and an example of experimental results.