gebhart/patrepeval huggingface dataset:
Discrete subadditive functions as Gomory functions (1995)

Our aim, in this paper, is to study a class of functions which occurs in pure integer programming, and to investigate conditions under which discrete subadditive functions belong to that class. The inspiration for the paper was the problem of classifying discrete metrics used in pattern recognition, while the methods of proof of the main theorem are those of pure integer programming.
The efficacy and safety of anti-CD19/CD20 chimeric antigen receptor- T cells immunotherapy in relapsed or refractory B-cell malignancies:a meta-analysis (2018)

In conclusion, CAR T therapy has promising outcomes with tolerable AEs in relapsed or refractory B-cell malignancies. Further modifications of CAR structure and optimal therapy strategy in continued clinical trials are needed to obtain significant improvements.
Agent-based Simulation of the Maritime Domain (2010)

In this paper, a multi-agent based simulation platform is introduced that focuses on legitimate and illegitimate aspects of maritime traffic, mainly on intercontinental transport through piracy afflicted areas. The extensible architecture presented here comprises several modules controlling the simulation and the life-cycle of the agents, analyzing the simulation output and visualizing the entire simulated domain. The simulation control module is initialized by various configuration scenarios to simulate various real-world situations, such as a pirate ambush, coordinated transit through a transport corridor, or coastal fishing and local traffic. The environmental model provides a rich set of inputs for agents that use the geo-spatial data and the vessel operational characteristics for their reasoning. The agent behavior model based on finite state machines together with planning algorithms allows complex expression of agent behavior, so the resulting simulation output can serve as a substitution for real world data from the maritime domain.
The Pharmacokinetics, Distribution and Degradation of Human Recombinant Interleukin 1β in Normal Rats (1991)

Based upon in vivo rat experiments it was recently suggested that interleukin 1 in the circulation may be implicated in the initial events of beta-cell destruction leading to insulin-dependent diabetes mellitus (IDDM) in humans. The aim of the present study was to estimate half-lives of distribution (T1/2 alpha) and elimination phases (T1/2 beta) of human recombinant interleukin 1 beta (rIL-1 beta), and its tissue distribution and cellular localization by means of mono-labelled, biologically active 125I-rIL-1 beta. After intravenous (i.v.) injection, 125I-rIL-1 beta was eliminated from the circulation with a T1/2 alpha of 2.9 min and a T1/2 beta of 41.1 min. The central and peripheral volume of distribution was 20.7 and 19.1 ml/rat, respectively, and the metabolic clearance rate was 16.9 ml/min/kg. The kidney and liver showed the highest accumulation of tracer, and autoradiography demonstrated that 125I-rIL-1 beta was localized to the proximal tubules in the kidney and to the hepatocytes in the liver. Furthermore, grains were localized to the islets of Langerhans in the pancreas. Tracer-bound proteins corresponding to intact 125I-rIL-1 beta were found in the circulation after i.v., intraperitoneal (i.p.) and subcutaneous (s.c.) injections, as demonstrated by high performance size exclusion chromatography, trichloracetic acid precipitation and SDS-PAGE until 5 h after tracer injection. Pre-treatment with 'cold' rIL-1 beta enhanced degradation of a subsequent injection of tracer. The route of administration was of importance for the biological effects of rIL-1 beta, as demonstrated by a reduced food intake, increased rectal temperature and blood glucose after s.c. injection of rIL-1 beta compared with i.p. The present demonstration of intact rIL-1 beta in the circulation and the islets of Langerhans supports the hypothesis that systemic IL-1 beta may be involved in the initial beta-cell destruction leading to IDDM in humans.
Bayesian network models for error detection in radiotherapy plans (2015)

The purpose of this study is to design and develop a probabilistic network for detecting errors in radiotherapy plans for use at the time of initial plan verification. Our group has initiated a multi-pronged approach to reduce these errors. We report on our development of Bayesian models of radiotherapy plans. Bayesian networks consist of joint probability distributions that define the probability of one event, given some set of other known information. Using the networks, we find the probability of obtaining certain radiotherapy parameters, given a set of initial clinical information. A low probability in a propagated network then corresponds to potential errors to be flagged for investigation. To build our networks we first interviewed medical physicists and other domain experts to identify the relevant radiotherapy concepts and their associated interdependencies and to construct a network topology. Next, to populate the network's conditional probability tables, we used the Hugin Expert software to learn parameter distributions from a subset of de-identified data derived from a radiation oncology based clinical information database system. These data represent 4990 unique prescription cases over a 5 year period. Under test case scenarios with approximately 1.5% introduced error rates, network performance produced areas under the ROC curve of 0.88, 0.98, and 0.89 for the lung, brain and female breast cancer error detection networks, respectively. Comparison of the brain network to human experts performance (AUC of 0.90 ± 0.01) shows the Bayes network model performs better than domain experts under the same test conditions. Our results demonstrate the feasibility and effectiveness of comprehensive probabilistic models as part of decision support systems for improved detection of errors in initial radiotherapy plan verification procedures.
A low quiescent-current, low supply-voltage linear regulator (2004)

A new design for a low-dropout regulator circuit is presented in this work. The circuit is based on the driving of a pass element using two switches, thus improving the slew rate performance of the typical error amplifier. The circuit provides an accurate output voltage, which can drive different capacitive loads within the range of 500 nF to 4.7 /spl mu/F (or bigger), with remarkable transient and steady state performance.
High-performance low-power left-to-right array multiplier design (2005)

We present a high-performance low-power design of linear array multipliers based on a combination of the following techniques: signal flow optimization in [3:2] adder array for partial product reduction, left-to-right leapfrog (LRLF) signal flow, and splitting of the reduction array into upper/lower parts. The resulting upper/lower LRLF (ULLRLF) multiplier is compared with tree multipliers. From automatic layout experiments, we find that ULLRLF multipliers have similar power, delay, and area as tree multipliers for n/spl les/32. With more regularity and inherently shorter interconnects, the ULLRLF structure presents a competitive alternative to tree structures in the design of fast low-power multipliers implemented in deep submicron VLSI technology.
Metals Exposures of Residents Living Near the Akaki River in Addis Ababa, Ethiopia: A Cross-Sectional Study (2015)

Most of the exposures found during this investigation seem unlikely to cause acute health effects based on known toxic thresholds. However, toxicity data for many of these metals are very limited.
Highly sensitive contactless conductivity microchips based on concentric electrodes for flow analysis (2013)

In this communication, we describe for the first time the integration of concentric electrodes (wrapping around the microchannel) in microchips. The use of such electrodes has been shown to be effective towards improvement of the sensitivity and detectability in pressure-driven flow platforms incorporating C(4)D.
Analysis of an ONO gate film effect on n- and p-MOSFET mobilities (1990)

The effect of the nitrogen atoms in the gate oxide and why gate oxide nitridation acts oppositely on the n- and p-MOSFET mobilities were studied. It was found that the mobility changes for the oxide/nitride/oxide (ONO) gate MOSFETs are not caused by the high-temperature process during the rapid thermal process (RTP), but rather are caused by the involvement of the nitrogen atoms in the gate oxide. The interfacial structures were observed by TEM. Although some interfacial structure difference was observed, there was no major difference in surface roughness between `PO' and `NO' samples. The opposite effect of the ONO gate films on the n- and p-MOSFET mobilities cannot be explained completely by a donor layer formation by the nitrogen diffusion into the substrate. The effect might be explained by the residual mechanical stress caused by the involvement of the nitrogen atoms in the gate oxide
Design of Employee Management Application for Small Medium Enterprise (2021)

Information technology has become the basis in various companies to support operations and management so that companies in various fields have begun to develop information technology within their companies to compete in their competition. By developing information technology in a company, it can increase the productivity of a company. The objectives of this research are: Designing applications for Small and Medium Enterprises such as calculating employee absences, leave, overtime, BPJS, PPh21 to assist Small and Medium Enterprises in managing employees, designing reports that can help SME owners to view employee data and monitor employee attendance/permission. The methodology used for designing this system was study literature, interviews with employees and small-medium enterprise owners, and System Development Life Cycle (SDLC). The benefit of this research is that it helps SME owners to view employee data and monitor employee attendance/permits.
Purified Inactivated Zika Vaccine Candidates Afford Protection against Lethal Challenge in Mice (2018)

In response to the 2016 global public health emergency of international concern announced by the World Health Organization surrounding Zika virus (ZIKV) outbreaks, we developed a purified inactivated Zika virus vaccine (PIZV) candidate from ZIKV strain PRVABC59, isolated during the outbreak in 2015. The virus isolate was plaque purified, creating six sub-isolated virus stocks, two of which were selected to generate PIZV candidates for preclinical immunogenicity and efficacy evaluation in mice. The alum-adjuvanted PIZV candidates were highly immunogenic in both CD-1 and AG129 mice after a 2-dose immunization. Further, AG129 mice receiving 2 doses of PIZV formulated with alum were fully protected against lethal ZIKV challenge and mouse immune sera elicited by the PIZV candidates were capable of neutralizing ZIKVs of both African and Asian genetic lineages in vitro. Additionally, passive immunization of naïve mice with ZIKV-immune serum showed strong positive correlation between neutralizing ZIKV antibody (NAb) titers and protection against lethal challenge. This study supported advancement of the PIZV candidate toward clinical development.
Shear waves revealed: Extensive‐dilatancy anisotropy confirmed (1986)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1986Shear waves revealed: Extensive‐dilatancy anisotropy confirmedAuthors: Stuart CrampinIain BushStuart CrampinBritish Geological Survey and Iain BushBritish Geological Survey and University of Edinburgh, Scotlandhttps://doi.org/10.1190/1.1893033 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1893033FiguresReferencesRelatedDetailsCited byThe effect of geologic structure on fracture characterization using azimuthal vertical seismic profilesAli Sayed, Robert R. Stewart, and Dhananjay Kumar21 January 2021 | GEOPHYSICS, Vol. 86, No. 1Azimuthal 3D seismic data, ISIP's, and micro-seismic data evaluated for unconventional completions in a fractured carbonate reservoirHeloise Bloxsom Lynn*19 August 2015Azimuthal anisotropy: Distinguishing between unequal horizontal stress and vertical aligned macro-fractures, as demonstrated in thirty years of field data analysisHeloise Bloxsom Lynn*5 August 2014Magnetic inference of in situ open microcracks in sandstone samples from the Taiwan Chelungpu Fault Drilling Project (TCDP)Journal of Asian Earth Sciences, Vol. 45Analysis of Shear-Wave Polarization in VSP Data: A Tool for Reservoir Development1 December 1995 | SPE Formation Evaluation, Vol. 10, No. 04Paris Basin VSPs: case history establishing combinations of fine-layer (or lithologic) anisotropy and crack anisotropy from modelling shear wavefields near point singularitiesGeophysical Journal International, Vol. 107, No. 3EXAMINATION OF A SPECTRAL METHOD FOR MEASURING THE EFFECTS OF ANISOTROPY1Geophysical Prospecting, Vol. 39, No. 5COMPARISON OF SIGNAL PROCESSING TECHNIQUES FOR ESTIMATING THE EFFECTS OF ANISOTROPY1Geophysical Prospecting, Vol. 39, No. 3Stress in the Earth's crust: the link between crustal fluids and extensive-dilatancy anisotropy6 June 2022 | Journal of the Geological Society, Vol. 147, No. 6SUGGESTIONS FOR A CONSISTENT TERMINOLOGY FOR SEISMIC ANISOTROPY1Geophysical Prospecting, Vol. 37, No. 7ELASTIC WAVE PROPAGATION IN MEDIA WITH PARALLEL FRACTURES AND ALIGNED CRACKS1Geophysical Prospecting, Vol. 36, No. 6 SEG Technical Program Expanded Abstracts 1986ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1986 Pages: 715 publication data© 1986 Copyright © 1986 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 07 Mar 2005 CITATION INFORMATION Stuart Crampin and Iain Bush, (1986), "Shear waves revealed: Extensive‐dilatancy anisotropy confirmed," SEG Technical Program Expanded Abstracts : 481-484. https://doi.org/10.1190/1.1893033 Plain-Language Summary PDF DownloadLoading ...
Inlet Fogging of Gas Turbine Engines: Part A — Theory, Psychrometrics and Fog Generation (2000)

Gas Turbine output is a strong function of the ambient air temperature with power output dropping by 0.3–0.5 % for every 1°F rise in ambient temperature. This loss in output presents a significant problem to utilities, cogenerators and IPPs when electric demands are high during the hot months. In the petrochemical and process industry, the reduction in output of mechanical drive gas turbines curtails plant output. One way to counter this drop in output is to cool the inlet air. The paper contrasts the traditional evaporative cooling technique with direct inlet fogging. The state of the art relating to fog generation and psychrometrics of inlet fogging are described.
Particles Trapped at the Droplet Interface in Water-in-Water Emulsions (2012)

Water-in-water emulsions were formed by mixing incompatible aqueous solutions of dextran and poly(ethylene oxide) (PEO) in the presence of latex or protein particles. It was found that particles with a radius as small as 0.1 μm become trapped at the interface between the PEO- and dextran-rich phases with interfacial tensions down to 10(-6) N/m. The particles were visualized at the interface of the emulsion droplets using confocal laser scanning microscopy (CLSM) allowing determination of the contact angle. Various degrees of coverage with particles could be observed. On densely covered droplets, the particles had a hexagonal crystalline order. At intermediate coverage, transient clustering of the particles was observed. The diffusion coefficient of the particles at the interface was determined using multiparticle tracking. Fusion of droplets was observed in all cases leading eventually to macroscopic phase separation.
Meat and Fish Consumption and Cancer in Canada (2008)

In this study, we examined the association between meat and fish intake and the risk of various cancers. Mailed questionnaires were completed by 19,732 incident, histologically confirmed cases of cancer of the stomach, colon, rectum, pancreas, lung, breast, ovary, prostate, testis, kidney, bladder, brain, non-Hodgkin's lymphomas (NHL), and leukemia and 5,039 population controls between 1994 and 1997 in 8 Canadian provinces. Measurement included information on socioeconomic status, lifestyle habits, and diet. A 69-item food frequency questionnaire provided data on eating habits 2 yr before data collection. Odds ratios and 95% confidence intervals were derived through unconditional logistic regression. Total meat and processed meat were directly related to the risk of stomach, colon, rectum, pancreas, lung, breast (mainly postmenopausal), prostate, testis, kidney, bladder, and leukemia. Red meat was significantly associated with colon, lung (mainly in men), and bladder cancer. No relation was observed for cancer of the ovary, brain, and NHL. No consistent excess risk emerged for fish and poultry, which were inversely related to the risk of a number of cancer sites. These findings add further evidence that meat, specifically red and processed meat, plays an unfavorable role in the risk of several cancers. Fish and poultry appear to be favorable diet indicators.
Effect of a High-Monounsaturated Fat Diet Enriched With Avocado in NIDDM Patients (1994)

OBJECTIVE To assess the effects of two controlled diets, one rich in oleic acid obtained from avocado and olive oil and the other rich in complex carbohydrates, on fasting and postprandial serum lipids and glycemic control in 12 women with NIDDM. RESEARCH DESIGN AND METHODS A randomized crossover study was designed. During a 4-week baseline period, all patients received the isocaloric diets recommended by the American Diabetes Association. After this period the patients were randomly assigned to receive the two study diets alternately during two 4-week periods. One diet was high in monounsaturated fatty acids (HMUFA) and the other was high in complex carbohydrates (high-CHO). There also was a 4-week washout period in between the two 4-week periods during which the patients followed the American Diabetes Association's isocaloric diet. Blood samples were obtained before and after each dietary period. RESULTS Both diets had a minor hypocholesterolemic effect with no major changes in high-density lipoprotein cholesterol. The HMUFA diet was associated with a greater decrement in plasma triglycerides (20 vs. 7% in the high-CHO diet). Glycemic control was similar with both diets. CONCLUSIONS Partial replacement of complex digestible carbohydrates with monounsaturated fatty acids (avocado as one of its main sources) in the diet of patients with non-insulin-dependent diabetes mellitus improves the lipid profile favorably, mantains an adequate glycemic control, and offers a good management alternative.
Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition (2011)

These data indicate that bacterially expressed L1 RT is an active reverse transcriptase sensitive to nucleoside RT inhibitors but not to non-nucleoside inhibitors.
The impact of gate-driver parameters variation and device degradation in the PV-inverter lifetime (2014)

This paper introduces a reliability-oriented design tool for a new generation of grid connected PV-inverters. The proposed design tool consists of a real field Mission Profile (MP) model (for one year operation in USA-Arizona), a PV-panel model, a grid connected PV-inverter model, an Electro-Thermal model and the lifetime model of the power semiconductor devices. A simulation model able to consider a one year real field operation conditions (solar irradiance and ambient temperature) is developed. Thus, one year estimation of the converter devices thermal loading distribution is achieved and is further used as an input to a lifetime model. The proposed reliability oriented design tool is used to study the impact of MP-variation, Gate-Driver (GD) parameters variation and device degradation in the PV-inverter lifetime. The obtained results indicate that in order to improve the accuracy of the lifetime estimation it is crucial to consider also the device degradation feedback. Moreover the MP of the field where the PV-inverter is operating and the GD-parameters selection has an important impact in the converter reliability and it should be considered from the design stage to better optimize the converter design margin.
Charachterization and functional analysis of scFv-based CARs to redirect T cells to IL13Rα2-positive glioma (2015)

Meeting abstracts The goal of this project is to develop T cells that express chimeric antigen receptors (CARs) as an effective immunotherapy for glioblastoma (GBM), the most aggressive, primary brain tumor in humans, which outcome remains poor. IL13Rα2 is aberrantly expressed in GBM and therefore
High-resolution extracellular stimulation of dispersed hippocampal culture with high-density CMOS multielectrode array based on non-Faradaic electrodes (2011)

We introduce a method to electrically stimulate individual neurons at single-cell resolution in arbitrary spatiotemporal patterns with precise control over stimulation thresholds. By exploiting a custom microelectronic chip, up to 65,000 non-Faradaic electrodes can be uniquely addressed with electrode density exceeding 6500 electrodes mm(-2). We demonstrate extracellular stimulation of dispersed primary hippocampal neuronal cultures using the chip at single-cell resolution.
<title>Text/graphics separation for technical papers</title> (1995)

One of the important operations in automatic analysis of technical papers is a text separation from graphics. In practice, a document skew often occurs both for initial document and for its image after scanning. Also text and graphic blocks can exist which have no rectangular shape. In these cases, the standard text/graphics separation methods such as projection profiles or run length smoothing are not always suitable. In this paper, we propose the text/graphics separation algorithm based on two simple and standard properties of technical paper pages. We call them as area and text compactness properties. The area property takes into account the geometrical relationships between text and graphics. The text compactness property reflects the spatial relationships between text components within block and between text and graphics. An application of both properties allows us to accurately perform the separation in the cases above. No skew correction is required before separation and text and graphic blocks can have arbitrary shape.
Preparation and Application of two Monoclonal Antibodies against Canine Parvovirus Vaccine and Field Strains. (2017)

Background: Canine parvovirus (CPV) emerged in 1970s as a highly infectious disease. CPV modifi ed live vaccines have been widely used to control the disease. It is urgent to develop specifi c monoclonal antibodies to differentiate fi eld virus from vaccine virus in vaccinated dogs.
How Cells Handle Cholesterol (2000)

Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Recent advances suggest that cholesterol exerts many of its actions mainly by maintaining sphingolipid rafts in a functional state. How rafts contribute to cholesterol metabolism and transport in the cell is still an open issue. It has long been known that cellular cholesterol levels are precisely controlled by biosynthesis, efflux from cells, and influx of lipoprotein cholesterol into cells. The regulation of cholesterol homeostasis is now receiving a new focus, and this changed perspective may throw light on diseases caused by cholesterol excess, the prime example being atherosclerosis.