gebhart/patrepeval huggingface dataset:
Oxidation Decomposition of Unsaturated Fatty Acids by Singlet Oxygen in Phospholipid Bilayer Membranes (2007)

Oxidation decomposition of unsaturated fatty acids with singlet oxygen generated from a photosensitizing agent was investigated in liposome bilayer membranes under a light irradiation condition. The liposome of which the bilayer membrane was composed of L-alpha-dipalmitoylphosphatidylcholine (DPPC), protoporphyrin IX (PpIX), and an unsaturated fatty acid (oleic acid, linoleic acid, alpha-linolenic acid, or arachidonic acid) were prepared with Bangham's method. In irradiating the liposome dispersion with light ranged from 550 to 750 nm, the unsaturated fatty acid was decomposed through an oxidation reaction with singlet oxygen. The decomposition rate constant was obeyed as the following order: arachidonic acid > oleic acid > alpha-linolenic acid > linoleic acid. This result indicates that oleic acid is readily degraded despite its lower unsaturated degree. In addition, micropolarity and microfluidity of the hydrocarbon region in the liposome bilayer membrane including the unsaturated fatty acid and PpIX decreased with an increase in light irradiation time. These findings suggest that interaction among the hydrocarbon chains of DPPC in the liposome bilayer membrane is promoted by migration of the oxidized unsaturated fatty acid from the hydrocarbon region, leading to form close-packed and well-ordered orientation of the hydrocarbon chains.
Bit synchronization using subcarriers for control signaling (1999)

We demonstrate bit synchronization of two 1-Gb/s nonreturn-to-zero input signals to within 125 ps (1/8 of a bit time) using a subcarrier as the control signal for determining the time delay between the two baseband channels. The 1-GHz subcarrier for each channel is superimposed onto the baseband data at the transmitter, then recovered and mixed in real time with a local clock at the switching node to generate a signal proportional to the relative phase differential. This phase differential signal is used to dynamically set optical space switches thereby controlling the path through a matrix of delay lines. Each channel is independently synchronized to the local clock, resulting in the synchronization of the two output streams to within a fraction of a bit time.
Message-Based Service Brokering and Dynamic Composition in the SAI Middleware (2010)

Service-Oriented Computing (SOC) is a wide and complex research area. Despite the huge effort in both industrial and academics initiatives, several challenges need to be addressed in order to effectively realize the SOC vision. One of the most relevant issues is the need of effective, flexible, reliable, low cost solutions for dynamic service brokering and composition. This paper presents results of an ongoing work on the design and development of a service- and message-oriented middleware for atomic and composite service brokering, named SAI middleware. The SAI middleware offers a set of features for service brokering and dynamic composition, while also guaranteeing loose coupling between service providers and consumers and relaxing the prerequisites for service providers to publish their capabilities in an interoperability domain. SAI dynamic composition is based on an Artificial Intelligence planning approach and on the adoption of an ontology-based functional profile encoding information for enabling automatic information extraction and combination in the service composition chain. Our main contribution consists in addressing these issues in a holistic way, as required to effectively support the SOA vision in real application scenarios, while not optimizing single aspects yet.
Silicone rubber with improved hydrophobicity (2015)

In outdoor insulation, a hydrophobic surface is crucial for minimizing leakage currents during severe weather conditions and in polluted environments. Silicone rubber is a commonly used insulation material with good hydrophobicity. However, the hydrophobicity may be temporarily reduced or even lost when silicone rubber worked under extreme pollution events, but will gradually recover with time. The current work is aiming at developing a silicone rubber formulation with improved hydrophobicity, such as increased hydrophobic recovery rate. This was achieved by adding silicone-based additives. The loss and recovery of hydrophobicity of the materials after exposure to corona discharges, as well as the hydrophobic transfer ability, were assessed by contact angle measurements. In addition, an inclined plane tracking test was carried out according to IEC 60587. The modified silicone rubber exhibited a more durable hydrophobicity during corona treatment and a faster recovery after end of exposure. The resistance to tracking and erosion behavior was maintained, compared to the reference materials. Unexpectedly, no improvement on the hydrophobicity transfer performance was noted.
Self-organization of digital documents based on process-oriented relations (2005)

This paper presents a novel mechanism for self-organization of structure among documents based on process oriented relations. Process-oriented relations represent operations and temporal distance between uses of documents in users' working processes. A complex new network of process-oriented relations is rearranged as a multi-layered document network (MLDN) with a recursive hypergraph structure. The MLDN is self-organized by two kinds of autonomous agent: a document agent and a group agent. This facility provides up-to-date, easy-to-understand structure among documents, and helps users' understanding of relations between documents.
Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic mouse model of infant undernutrition (2019)

Undernutrition in children is a pressing global health problem, manifested in part by impaired linear growth (stunting). Current nutritional interventions have been largely ineffective in overcoming stunting, emphasizing the need to obtain better understanding of its underlying causes. Treating Bangladeshi children with severe acute malnutrition with therapeutic foods reduced plasma levels of a biomarker of osteoclastic activity without affecting biomarkers of osteoblastic activity or improving their severe stunting. To characterize interactions among the gut microbiota, human milk oligosaccharides (HMOs), and osteoclast and osteoblast biology, young germ-free mice were colonized with cultured bacterial strains from a 6-mo-old stunted infant and fed a diet mimicking that consumed by the donor population. Adding purified bovine sialylated milk oligosaccharides (S-BMO) with structures similar to those in human milk to this diet increased femoral trabecular bone volume and cortical thickness, reduced osteoclasts and their bone marrow progenitors, and altered regulators of osteoclastogenesis and mediators of Th2 responses. Comparisons of germ-free and colonized mice revealed S-BMO-dependent and microbiota-dependent increases in cecal levels of succinate, increased numbers of small intestinal tuft cells, and evidence for activation of a succinate-induced tuft cell signaling pathway linked to Th2 immune responses. A prominent fucosylated HMO, 2'-fucosyllactose, failed to elicit these changes in bone biology, highlighting the structural specificity of the S-BMO effects. These results underscore the need to further characterize the balance between, and determinants of, osteoclastic and osteoblastic activity in stunted infants/children, and suggest that certain milk oligosaccharides may have therapeutic utility in this setting.
Friedel–Crafts Amidoalkylation via Thermolysis and Oxidative Photocatalysis (2012)

Friedel-Crafts amidoalkylation was achieved by oxidation of dialkylamides using persulfate (S(2)O(8)(2-)) in the presence of the visible light catalyst, Ru(bpy)(3)Cl(2), at room temperature, via a reactive N-acyliminium intermediate. Alternatively, mild heating of the dialkylamides and persulfate afforded a metal and Lewis acid-free Friedel-Crafts amidoalkylation. Alcohols and electron-rich arenes served as effective nucleophiles, forming new C-O or C-C bonds. In general, photocatalysis provided higher yields and better selectivities.
Significant NOx Reductions with Direct Water Injection into the Sub-Chamber of an IDI Diesel Engine (1995)

<div class="htmlview paragraph">The effect of direct water injection into the combustion chamber on NOx reduction in an IDI diesel engine was investigated. The temperature distribution in the swirl chamber was analyzed quantitatively with high speed photography and the two color method.</div> <div class="htmlview paragraph">Direct water injection into a swirl chamber prior to fuel injection reduced NOx emission significantly over a wide output range without sacrifice of BSFC. Other emissions were almost unchanged or slightly decreased with water injection. Water injection reduced the flame temperature at the center of the swirl chamber, while the mean gas temperature in the cylinder and the rate of heat release changed little.</div>
Outlook on PI3K/AKT/mTOR inhibition in acute leukemia (2015)

Technological advances allowing high throughput analyses across numerous cancer tissues have allowed much progress in understanding complex cellular signaling. In the future, the genetic landscape in cancer may have more clinical relevance than diagnosis based on tumor origin. This progress has emphasized PI3K/AKT/mTOR, among others, as a central signaling center of cancer development due to its governing control in cellular growth, survival, and metabolism. The discovery of high frequencies of mutations in the PI3K/AKT/mTOR pathway in different cancer entities has sparked interest to inhibit elements of this pathway. In acute leukemia pharmacological interruption has yet to achieve desirable efficacy as targetable downstream mutations in PI3K/AKT/mTOR are absent. Nevertheless, mutations in membrane-associated genes upstream of PI3K/AKT/mTOR are frequent in acute leukemia and are associated with aberrant activation of PI3K/AKT/mTOR thus providing a good rationale for further exploration. This review attempts to summarize key findings leading to aberrant activation and to reflect on both promises and challenges of targeting PI3K/AKT/mTOR in acute leukemia. Our emphasis lies on the insights gained through high-throughput data acquisition that open up new avenues for identifying specific subgroups of acute leukemia as ideal candidates for PI3K/AKT/mTOR targeted therapy.
Polyamide-6/Poly(lactic acid) Blends Compatibilized by the Maleic Anhydride Grafted Polyethylene-Octene Elastomer (2010)

To evaluate the feasibility of a strategy to partially replace polyamide-6 (PA6) with poly(lactic acid) (PLA), the morphology, mechanical, and thermal properties of PA6/PLA blending systems were investigated. Polyethylene-octene elastomer (POE) and POE grafted with maleic anhydride (POE-g-MAH) are added to improve the impact strength and elongation at break of the blend. The results show that POE-g-MAH is an effective compatibilizer for PA6/PLA blending system. Compared with the morphology of PA6/PLA/POE, smaller particle size, more homogeneous distribution of domains and improved interfacial adhesion between matrix and domains were observed in the PA6/PLA/POE-g-MAH blending system.
A comparative study of the structures and reactivity of cyclometallated platinum compounds of N-benzylidenebenzylamines and cycloplatination of a primary amine (2007)

The reaction of cis-[PtCl(2)(dmso)2] with ligands 4-ClC(6)H(4)CHNCH(2)C(6)H(5) (1a) and 4-ClC(6)H(4)CHNCH(2)(4-ClC(6)H(4)) (1b) in the presence of sodium acetate and using either methanol or toluene as solvent produced the corresponding five-membered endo-metallacycles [PtCl{(4-ClC(6)H(3))CHNCH(2)C(6)H(5)}{SOMe(2)}] (2a) and [PtCl{(4-ClC(6)H(3))CHNCH(2)(4'-ClC(6)H(4))}{SOMe(2)}] (2b). An analogous reaction for ligands 2,6-Cl(2)C(6)H(3)CHNCH(2)C(6)H(5) (1c) and 2,6-Cl(2)C(6)H(3)CHNCH(2)(4-ClC(6)H(4)) (1d) produced five-membered exo-metallacycles [PtCl{(2,6-Cl(2)C(6)H(3))CHNCH(2)C(6)H(4)}{SOMe(2)}] (2c) and [PtCl{(2,6-Cl(2)C(6)H(3))CHNCH(2)(4'-ClC(6)H(3))}{SOMe(2)}] (2d) when the reaction was carried out in methanol and seven-membered endo-platinacycles [PtCl{(MeC(6)H(3))ClC(6)H(3)CHNCH(2)C(6)H(4)}{SOMe(2)}] (3c) and [PtCl{(MeC(6)H(3))ClC(6)H(3)CHNCH(2)(4'-ClC(6)H(3))}{SOMe(2)}] (3d) when toluene was used as a solvent. The reaction of 2,4,6-(CH(3))(3)C(6)H(2)CHNCH(2)(4-ClC(6)H(4)) (1e) produced in both solvents an exo-platinacycle [PtCl{(2,4,6-(CH(3))(3)C(6)H(2))CHNCH(2)(4'-ClC(6)H(3))}{SO(CH(3))(2)}] (2e). Cyclometallation of 4-chlorobenzylamine was also achieved to produce compound [PtCl{(4-ClC(6)H(3))CH(2)NH(2)}{SOMe(2)}] (2g). The reactions of endo- and exo-metallacycles with phosphines evidenced the higher lability of the Pt-N bond in exo-metallacycles while a comparative analysis of the crystal structures points out a certain degree of aromaticity in the endo-metallacycle.
Operation Mode Analysis and Peak Gain Approximation of the LLC Resonant Converter (2011)

With the advantage of achieving zero voltage switching for a wide input voltage range, the LLC resonant topology has become increasingly popular for use in high power density and high-efficiency power converter applications. However, when the LLC converter is applied to wide input voltage range applications, the widely used fundamental harmonic approximation is incapable of guiding the design due to its inaccuracy. Thus an accurate LLC converter model is desired. In this paper, a generalized mode analysis is presented that provides highly accurate prediction on resonant current and voltage behavior and dc gain characteristic. Also, because operation modes are affected by load, frequency, and gain conditions, the boundaries and distribution of modes are discussed and illustrated. Based on the mode analysis, an approximation method is developed to estimate the peak gain point, which is useful in LLC design. This approximation demonstrates high accuracy within the simulation results. An experimental prototype is built to verify the analysis.
Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells (2008)

Pathogenic yeast Cryptococcus neoformans causes devastating cryptococcal meningoencephalitis. Our previous studies demonstrated that C. neoformans hyaluronic acid was required for invasion into human brain microvascular endothelial cells (HBMEC), which constitute the blood-brain barrier. In this report, we demonstrate that C. neoformans hyaluronic acid interacts with CD44 on HBMEC. Our results suggest that HBMEC CD44 is a primary receptor during C. neoformans infection, based on the following observations. First, anti-CD44 neutralizing antibody treatment was able to significantly reduce C. neoformans association with HBMEC. Second, C. neoformans association was considerably impaired using either CD44-knock-down HBMEC or C. neoformans hyaluronic acid-deficient strains. Third, overexpression of CD44 in HBMEC increased their association activity towards C. neoformans. Fourth, confocal microscopic images showed that CD44 was enriched at and around the C. neoformans association sites. Fifth, upon C. neoformans and HBMEC engagement, a subpopulation of CD44 and actin translocated to the host membrane rafts. Our results highlight the interactions between C. neoformans hyaluronic acid and host CD44 and the dynamic results of these interactions, which may represent events during the adhesion and entry of C. neoformans at HBMEC membrane rafts.
Total Synthesis of the Eight Diastereomers of the Syn-Anti-Syn Phytoprostanes F<sub>1</sub> Types I and II (2004)

Syntheses of the eight enantiomerically pure diastereomers of the syn-anti-syn phytoprostanes F(1) types I and II are described starting from D- and L-glucose. Key steps include Wittig coupling, Horner Wadsworth Emmons (HWE) reactions, and enantioselective reduction of alpha,beta-unsaturated ketones.
Disposition Kinetics and Tolerance of Escalating Single Doses of Ramelteon, a High‐Affinity MT<sub>1</sub> and MT<sub>2</sub> Melatonin Receptor Agonist Indicated for Treatment of Insomnia (2006)

Ramelteon is a selective MT(1)/MT(2) receptor agonist, indicated for insomnia treatment. Safety, tolerance, pharmacokinetics, and cognitive performance were evaluated following increasing ramelteon doses. Healthy adults (35-65 years) were randomly assigned to receive 1 of 5 oral ramelteon doses (4, 8, 16, 32, or 64 mg; n = 8 per group) or placebo (n = 20). C(max) and AUC(infinity) (mean [%CV]) increased with each dose: C(max) = 1.15 (109), 5.73 (97), 6.92 (77), 17.4 (76), and 25.9 (77) ng/mL, respectively, and AUC(infinity) = 1.71 (114), 6.95 (108), 9.88 (78), 22.5 (80), and 36.1 (71 n x h/mL), respectively. Mean T(max) values of 0.75 to 0.94 hours and mean elimination half-life of 0.83 to 1.90 hours remained relatively constant. Ramelteon was extensively metabolized. Besides ramelteon, 4 metabolites, M-I, M-II, M-III, and M-IV, were measured in serum. Metabolite M-II, which has shown weak ramelteon-like activity in vitro, was the major metabolite in serum. Digit Symbol Substitution Test and visual analog scale alertness scores were similar across all dose groups and did not differ from placebo. All adverse events were mild or moderate and resolved before study completion.
Effects of riboflavin/UVA corneal cross‐linking on keratocytes and collagen fibres in human cornea (2010)

Corneal cross-linking leads to keratocyte damage; after 6 months a repopulation by proliferating cells, a distribution of CD34-positive keratocytes as in control and an increase in collagen fibre diameter were observed. These modifications are the morphological correlate of the process leading to an increase in biomechanical stability.
High-performance MoS2 transistors with low-resistance molybdenum contacts (2014)

In this Letter, molybdenum (Mo) is introduced and evaluated as an alternative contact metal to atomically-thin molybdenum disulphide (MoS2), and high-performance field-effect transistors are experimentally demonstrated. In order to understand the physical nature of the interface and highlight the role of the various factors contributing to the Mo-MoS2 contacts, density functional theory (DFT) simulations are employed, which reveal that Mo can form high quality contact interface with monolayer MoS2 with zero tunnel barrier and zero Schottky barrier under source/drain contact, as well as an ultra-low Schottky barrier (0.1 eV) at source/drain-channel junction due to strong Fermi level pinning. In agreement with the DFT simulations, high mobility, high ON-current, and low contact resistance are experimentally demonstrated on both monolayer and multilayer MoS2 transistors using Mo contacts. The results obtained not only reveal the advantages of using Mo as a contact metal for MoS2 but also highlight the fact that the properties of contacts with 2-dimensional materials cannot be intuitively predicted by solely considering work function values and Schottky theory.
Measurement of birefringence and ellipticity of polarization eigenmodes in spun highly birefringent fibers using spectral interferometry and lateral point-force method (2018)

We show that the spectral interferometry method and the lateral point-force method used up to now to measure spectral dependence of the group and the phase modal birefringence in highly birefringent fibers with linearly polarized eigenmodes, can be after some modifications extended for the class of spun highly birefringent fibers with elliptically polarized modes. By combining the two methods, it is possible to determine spectral dependence of the group and phase elliptical birefringence in spun highly birefringent fibers. Moreover, if the fiber spin pitch is independently measured, the spectral dependence of ellipticity angle of polarization eigenmodes as well as the built-in linear phase and group birefringence, can be also obtained using the analytical relations between the parameters of spun and non-spun fibers. We demonstrate the effectiveness of the proposed approach in spectral measurements (700-1600 nm) of the spun side-hole and microstructured highly birefringent fibers with different birefringence dispersion and spin pitches ranging from 4.1 to 200 mm.
Can 3D light localization be reached in ‘white paint’? (2016)

When waves scatter multiple times in 3D random media, a disorder driven phase transition from diffusion to localization may occur (Anderson 1958 Phys. Rev.
L-selectin: mechanisms and physiological significance of ectodomain cleavage (2005)

L-selectin is a cell adhesion molecule consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. It is expressed on most leukocytes and is involved in their rolling on inflamed vascular endothelium prior to firm adhesion and transmigration. It is also required for the constitutive trafficking of lymphocytes through secondary lymphoid organs. Like most adhesion molecules, L-selectin function is regulated by a variety of mechanisms including gene transcription, post-translational modifications, association with the actin cytoskeleton, and topographic distribution. In addition, it is rapidly downregulated by proteolytic cleavage near the cell surface by ADAM-17 (TACE) and at least one other "sheddase". This process of "ectodomain shedding" results in the release of most of the extracellular portion of L-selectin from the cell surface while retaining the cytoplasmic, transmembrane, and eleven amino acids of the extracellular domain on the cell. This review will examine the mechanism(s) of L-selectin ectodomain shedding and discuss the physiological implications.
The effects of bradykinin on K<sup>+</sup> currents in NG108–15 cells treated with U73122, a phospholipase C inhibitor, or neomycin (1997)

1. Bradykinin has multiple effects on differentiated NG108-15 neuroblastoma x glioma cells: it increases Ins(1,4,5)P3 production and intracellular Ca2+ concentration [Ca2+]i evokes a Ca2+ activated K+ current (IK(Ca)) and inhibits M current (IM). We studied the effect of the aminosteroid U73122 and the antibiotic neomycin, both putative blockers of phospholipase C (PLC), on these four bradykinin effects. 2. Preincubation with 1 or 5 microM U73122 for 15 min partly suppressed Ins(1,4,5)P3 generation and the increase in [Ca2+]i induced by 1 microM bradykinin. U73122 10 microM caused total and irreversible inhibition. The inactive analogue U73343 was without effect. 3. Resting levels of Ins(1,4,5)P3 were not affected. However, resting [Ca2+]i was increased by 10 microM U73122, but not by U73343. Individual cells responded to 10 microM U73122 with a small increase in [Ca2+]i, followed in some cells by a large further rise. 4. Pretreatment of whole-cell clamped cells with 1 microM U73122 for 30 min reduced the bradykinin-induced IK(Ca) to a fifth of its normal size. To suppress it totally, a 7-12 min pretreatment with 5 microM U73122 was required. Again, U73343 was without effect. 5. U73122 and U73343 at concentrations of 5-10 microM irreversibly decreased the holding current (Ih) which at a holding potential of -30 or -20 mV mainly flows through open M channels. The decrease was often preceded by a transient increase. 6. M current (IM) measured with 1 s pulses, was also decreased by 5-10 microM U73122 and U73343, but short applications of U73122 could cause a small increase. The bradykinin-induced inhibition of IM was not affected by U73122. 7. Preincubation with 1 or 3 mM neomycin for 15 min did not affect Ins(1,4,5)P3 generation and the increase in [Ca2+]i induced by bradykinin. Pretreatment with 3 mM neomycin for about 20 min diminished the bradykinin-induced IK(Ca) to a fifth of its normal size. 8. The four main conclusions drawn from the results are: (a) U73122 suppresses bradykinin-induced PLC activation and IK(Ca), but not IM inhibition. (b) This indicates that the transient outward current IK(Ca), but not the decrease of IM in response to bradykinin, is mediated by PLC. (c) U73122 itself inhibits IM and mobilizes Ca2+ from intracellular stores. (d) Externally applied neomycin is not an effective inhibitor of PLC-mediated signalling pathways in NG108-15 cells.