gebhart/patrepeval huggingface dataset:
Different data from different labs: Lessons from studies of gene–environment interaction (2002)

It is sometimes supposed that standardizing tests of mouse behavior will ensure similar results in different laboratories. We evaluated this supposition by conducting behavioral tests with identical apparatus and test protocols in independent laboratories. Eight genetic groups of mice, including equal numbers of males and females, were either bred locally or shipped from the supplier and then tested on six behaviors simultaneously in three laboratories (Albany, NY; Edmonton, AB; Portland, OR). The behaviors included locomotor activity in a small box, the elevated plus maze, accelerating rotarod, visible platform water escape, cocaine activation of locomotor activity, and ethanol preference in a two-bottle test. A preliminary report of this study presented a conventional analysis of conventional measures that revealed strong effects of both genotype and laboratory as well as noteworthy interactions between genotype and laboratory. We now report a more detailed analysis of additional measures and view the data for each test in different ways. Whether mice were shipped from a supplier or bred locally had negligible effects for almost every measure in the six tests, and sex differences were also absent or very small for most behaviors, whereas genetic effects were almost always large. For locomotor activity, cocaine activation, and elevated plus maze, the analysis demonstrated the strong dependence of genetic differences in behavior on the laboratory giving the tests. For ethanol preference and water escape learning, on the other hand, the three labs obtained essentially the same results for key indicators of behavior. Thus, it is clear that the strong dependence of results on the specific laboratory is itself dependent on the task in question. Our results suggest that there may be advantages of test standardization, but laboratory environments probably can never be made sufficiently similar to guarantee identical results on a wide range of tests in a wide range of labs. Interpretations of our results by colleagues in neuroscience as well as the mass media are reviewed. Pessimistic views, prevalent in the media but relatively uncommon among neuroscientists, of mouse behavioral tests as being highly unreliable are contradicted by our data. Despite the presence of noteworthy interactions between genotype and lab environment, most of the larger differences between inbred strains were replicated across the three labs. Strain differences of moderate effects size, on the other hand, often differed markedly among labs, especially those involving three 129-derived strains. Implications for behavioral screening of targeted and induced mutations in mice are discussed.
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC) (2019)

The RAS/MAPK pathway is a major driver of oncogenesis and is dysregulated in approximately 30% of human cancers, primarily by mutations in the BRAF or RAS genes. The extracellular-signal-regulated kinases (ERK1 and ERK2) serve as central nodes within this pathway. The feasibility of targeting the RAS/MAPK pathway has been demonstrated by the clinical responses observed through the use of BRAF and MEK inhibitors in BRAF V600E/K metastatic melanoma; however, resistance frequently develops. Importantly, ERK1/2 inhibition may have clinical utility in overcoming acquired resistance to RAF and MEK inhibitors, where RAS/MAPK pathway reactivation has occurred, such as relapsed BRAF V600E/K melanoma. We describe our structure-based design approach leading to the discovery of AZD0364, a potent and selective inhibitor of ERK1 and ERK2. AZD0364 exhibits high cellular potency (IC<sub>50</sub> = 6 nM) as well as excellent physicochemical and absorption, distribution, metabolism, and excretion (ADME) properties and has demonstrated encouraging antitumor activity in preclinical models.
Capillary electrophoretic separation of structurally similar solutes in noncross‐linked poly(acrylamide‐<i>co‐N</i>‐isopropylacrylamide) solution (1997)

Noncross-linked acrylamide (AA)-N-isopropylacrylamide (IPAAm) copolymers have been used as a buffer additive in capillary electrophoretic separation of structurally similar small solutes. Seven kinds of barbiturates and five kinds of dansylated (Dns) amino acids, which have different hydrophobic side chains, were separated on poly(AA-co-IPAAm)-filled columns and on AA polymer-filled columns under the condition of totally eliminating the contribution of electroosmotic flow (EOF). It is known that the copolymer containing IPAAm has thermosensitive properties, and the hydrophobicity of its surface changes with surrounding temperature. In this investigation, therefore, the effects of an isopropyl group in the copolymer on the electrophoretic separation of the small solutes were studied by comparing the two polymer-filled columns at ambient temperature and at elevated temperature. Although slight differences in migration behavior were observed at ambient temperature between the columns filled with these two polymer solutions, obvious differences in the separation of the solutes were observed at elevated temperature. The observed changes on the migration behavior might be caused by the interaction between copolymer chains exhibiting hydrophobic property and the solute.
A maize resistance gene functions against bacterial streak disease in rice (2005)

Although cereal crops all belong to the grass family (Poacea), most of their diseases are specific to a particular species. Thus, a given cereal species is typically resistant to diseases of other grasses, and this nonhost resistance is generally stable. To determine the feasibility of transferring nonhost resistance genes (R genes) between distantly related grasses to control specific diseases, we identified a maize R gene that recognizes a rice pathogen, Xanthomonas oryzae pv. oryzicola, which causes bacterial streak disease. Bacterial streak is an important disease of rice in Asia, and no simply inherited sources of resistance have been identified in rice. Although X. o. pv. oryzicola does not cause disease on maize, we identified a maize gene, Rxo1, that conditions a resistance reaction to a diverse collection of pathogen strains. Surprisingly, Rxo1 also controls resistance to the unrelated pathogen Burkholderia andropogonis, which causes bacterial stripe of sorghum and maize. The same gene thus controls resistance reactions to both pathogens and nonpathogens of maize. Rxo1 has a nucleotide-binding site-leucine-rich repeat structure, similar to many previously identified R genes. Most importantly, Rxo1 functions after transfer as a transgene to rice, demonstrating the feasibility of nonhost R gene transfer between cereals and providing a valuable tool for controlling bacterial streak disease.
Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers (2011)

No significant changes were observed in biomarkers of oxidative stress, including glutathione status, in this clinical trial of oral glutathione supplementation in healthy adults.
The neuroscience of positive emotions and affect: Implications for cultivating happiness and wellbeing (2020)

This review paper provides an integrative account regarding neurophysiological correlates of positive emotions and affect that cumulatively contribute to the scaffolding for happiness and wellbeing in humans and other animals. This paper reviews the associations among neurotransmitters, hormones, brain networks, and cognitive functions in the context of positive emotions and affect. Consideration of lifespan developmental perspectives are incorporated, and we also examine the impact of healthy social relationships and environmental contexts on the modulation of positive emotions and affect. The neurophysiological processes that implement positive emotions are dynamic and modifiable, and meditative practices as well as flow states that change patterns of brain function and ultimately support wellbeing are also discussed. This review is part of "The Human Affectome Project" (http://neuroqualia.org/background.php), and in order to advance a primary aim of the Human Affectome Project, we also reviewed relevant linguistic dimensions and terminology that characterizes positive emotions and wellbeing. These linguistic dimensions are discussed within the context of the neuroscience literature with the overarching goal of generating novel recommendations for advancing neuroscience research on positive emotions and wellbeing.
AIDA: Automated analog IC design flow from circuit level to layout (2012)

This paper presents AIDA, an analog integrated circuit design automation environment, which implements a design flow from a circuit-level specification to a physical layout description. AIDA results from the integration of two in-house tools, namely, GENOM-POF and LAYGEN II. GENOM-POF performs fully automated circuit-level synthesis implemented with a multi-objective multi-constraint optimization approach, which addresses robust design requirements by considering Corners analysis together with an electrical simulator as the evaluation engine. LAYGEN II implements a DRC proved fully automated layout generation based on a sized circuit-level description and high level layout guidelines, described in a technology independent abstract layout template. The expert knowledge is used by LAYGEN II to guide the evolutionary optimization kernels during the automatic layout generation. Moreover, evolutionary computation techniques are extensively used, at both circuit-level and physical-level, as tool to solve design optimization problems. Finally, AIDA environment is demonstrated for the IC design of a classical circuit-level topology and state-of-the-art technology, and validated by industrial simulators and analysis tools, such as, HSPICE <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> and CALIBRE <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> .
Abatement of acid mine drainage by encapsulation of acid-producing geological material. Final research report, 1 August 1990-31 October 1992 (1992)

A novel coating technology was developed to prevent pyrite oxidation and acid production in coal waste. The mechanism underlying this technology involves leaching coal waste with a coating solution composed of H2O2, KH2PO4, and sodium acetate (NaAC). During the leaching process, H2O2 oxidizes pyrite and produces Fe3+ so that iron phosphate precipitates as a coating on pyrite surfaces. The purpose of NaAC in the coating solution is to eliminate the inhibitory effect of the protons, produced during pyrite oxidation, on the precipitation of iron phosphate. In the study, it was shown that iron phosphate coatings on pyrite surfaces could be established by consuming 5% to 10% of the available pyrite, under a wide range of conditions. It was also demonstrated in the study that iron phosphate coatings on pyrite surfaces could prevent pyrite oxidation and acid production in coal waste.
A Robust Shadow Matching Algorithm for <i>GNSS</i> Positioning (2015)

Commercial GNSS devices tend to perform poorly in urban canyon environments. The dense and tall buildings block the signals from many of the satellites. In this work, we present a particle filter algorithm for a Shadow Matching framework to face this problem. Given a 3D city map and given the satellites' signal properties, the algorithm calculates in real-time invalid regions inside the Region Of Interest (ROI). This approach reduces the ROI to a fraction of its original size. We present a general framework for a Shadow Matching positioning algorithm based on a modified particle filter. Using simulation experiments we have shown that the suggested method can improve the accuracy of existing GNSS devices in urban regions. Moreover, the proposed algorithm can be efficiently extended to 3D positioning in high sampling rate, inherently applicable for UAVs and Drones. Copyright © 2015 Institute of Navigation.
Inflammatory Response in the CNS: Friend or Foe? (2016)

Inflammatory reactions could be both beneficial and detrimental to the brain, depending on strengths of their activation in various stages of neurodegeneration. Mild activation of microglia and astrocytes usually reveals neuroprotective effects and ameliorates early symptoms of neurodegeneration; for instance, released cytokines help maintain synaptic plasticity and modulate neuronal excitability, and stimulated toll-like receptors (TLRs) promote neurogenesis and neurite outgrowth. However, strong activation of glial cells gives rise to cytokine overexpression/dysregulation, which accelerates neurodegeneration. Altered mutual regulation of p53 protein, a major tumor suppressor, and NF-κB, the major regulator of inflammation, seems to be crucial for the shift from beneficial to detrimental effects of neuroinflammatory reactions in neurodegeneration. Therapeutic intervention in the p53-NF-κB axis and modulation of TLR activity are future challenges to cope with neurodegeneration.
Antenna-coupled metal-oxide-metal diodes for dual-band detection at 92.5 GHz and 28 THz (2004)

An antenna-coupled metal-oxide-metal diode for dual-band infrared millimetre-wave detection is presented. Electron-beam lithography and conventional sputtering methods were used to fabricate an Ni-NiO-Ni diode coupled to a lambda/2 resonant dipole antenna at 28 THz and lambda/2 resonant mmW slot antenna at 92.5 GHz; simultaneous dual-band detection was tested and verified.
An efficient DSP-based implementation of a fast convolution approach with non uniform partitioning (2012)

Finite impulse response convolution is one of the most widely used operation in digital signal processing field for filtering operations. In this context, low computationally demanding techniques become essential for calculating convolutions with low input/output latency in real scenarios, considering that the real time requirements are strictly related to the impulse response length. In this context, an efficient DSP implementation of a fast convolution approach is presented with the aim of lowering the workload required in applications like reverberation. It is based on a non uniform partitioning of the impulse response and a psychoacoustic technique derived from the human ear sensitivity. Several results are reported in order to prove the effectiveness of the proposed approach also introducing comparisons with the existing techniques of the state of the art.
Design of oxygen sensors based on quenching of luminescent metal complexes: Effect of ligand size on heterogeneity (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign of oxygen sensors based on quenching of luminescent metal complexes: Effect of ligand size on heterogeneityLouAnn. Sacksteder, J. N. Demas, and B. A. DeGraffCite this: Anal. Chem. 1993, 65, 23, 3480–3483Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ac00071a024https://doi.org/10.1021/ac00071a024research-articleACS PublicationsRequest reuse permissionsArticle Views458Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of Symptomatic and Asymptomatic Atherosclerotic Carotid Plaque Features with in Vivo MR Imaging (2006)

This study revealed significant differences between symptomatic and asymptomatic plaques in the same patient.
Immunostimulatory properties and antitumor activities of glucans (2013)

New foods and natural biological modulators have recently become of scientific interest in the investigation of the value of traditional medical therapeutics. Glucans have an important part in this renewed interest. These fungal wall components are claimed to be useful for various medical purposes and they are obtained from medicinal mushrooms commonly used in traditional Oriental medicine. The immunotherapeutic properties of fungi extracts have been reported, including the enhancement of anticancer immunity responses. These properties are principally related to the stimulation of cells of the innate immune system. The discovery of specific receptors for glucans on dendritic cells (dectin-1), as well as interactions with other receptors, mainly expressed by innate immune cells (e.g., Toll-like receptors, complement receptor-3), have raised new attention toward these products as suitable therapeutic agents. We briefly review the characteristics of the glucans from mycelial walls as modulators of the immunity and their possible use as antitumor treatments.
Acquired von Willebrand's disease: A concise review (1997)

Acquired von Willebrand's disease (AvWD), an adult-onset bleeding diathesis, has most commonly been found in patients with an underlying lymphoproliferative disease or monoclonal gammopathy. Other malignancies, autoimmune diseases, hypothyroidism, and drugs have also been associated with AvWD. We have included an illustrative case history of a patient with a bleeding diathesis consistent with AvWD and a monoclonal gammopathy who required emergent cardiac surgery. Our review of the literature determined that most cases of AvWD are due to a circulating antibody that combines with the high molecular weight multimers (HMWM) of von Willebrand factor (vWF). These vWF multimer-antibody complexes are subsequently cleared from the circulation either by the reticuloendothelial system or by adsorption onto tumor cells. Clearance of the HMWM of vWF thus results in extremely low functional levels and variable antigenic levels. Mixing studies which are traditionally used to diagnose factor inhibitors are useful only if removal of vWF-antibody complexes can be accomplished in vitro. Treatment with intravenous immunoglobulin has recently been shown to be the most effective therapy for patients with an underlying lymphoproliferative disorder or monoclonal gammopathy. This therapeutic strategy is based on the observed immune complex clearance phenomenon that appears to be operative in most cases. Other AvWD-associated diseases require treatment specifically directed at the underlying disorder.
Optical Monitoring of Thin-films Using Spectroscopic Ellipsometry (2002)

Spectroscopic Ellipsometry (SE) offers a precise technique for measuring thin film properties. Advanced SE instrumentati on has been demonstrated as an excellent technique for monitoring the growth of op tical films for sputtering applications. We have recently extended this technique for PVD E-gun evaporated films. In this paper we will show how an SE system was integrated into a standard optical coating system with an electron beam source and used for in situ film thickness monitoring of the growth of single layer films. During deposition of the films, the SE provided real time determination of the film thickness and refractive index. Additionally, the SE data was analyzed to study the homogeneity of the films. Finally a model was developed for in situ control of multi-layer stacks and demonstrated for a 3-cavity 17layer band pass filter.
Application of cellulases from an alkalothermophilic <i>Thermomonospora</i> sp. in biopolishing of denims (2006)

Use of cellulase for denim washing is a standard eco-friendly technique to achieve desirable appearance and softness for cotton fabrics and denims. But enzymatic washing of denim till date involved acid cellulase (Trichoderma reesei) and neutral cellulase (Humicola isolens) the use of which has a drawback of backstaining of the indigo dye on to the fabric. Though it has been suggested that pH is a major factor in controlling backstaining there are no reports on use of cellulase under alkaline conditions for denim washing. In this study for the first time an alkali stable endoglucanase from alkalothermophilic Thermomonospora sp. (T-EG) has been used for denim biofinishing under alkaline conditions. T-EG is effective in removing hairiness with negligible weight loss and imparting softness to the fabric. Higher abrasive activity with lower backstaining was a preferred property for denim biofinishing exhibited by T-EG. The activities were comparable to acid and neutral cellulases that are being regularly used. The enzyme was also effective under non-buffering conditions which is an added advantage for use in textile industry. A probable mechanism of enzymatic finishing of cotton fabric has been represented based on the unique properties of T-EG.
Characteristics of an Elevated Temperature ALN Particulate Reinforced NiAl (1993)

High energy milling of NiAl in liquid nitrogen (cryomilling) leads to the formation of a discontinuously AlN particle reinforced aluminide which has shown good potential as a high strength oxidation resistant material. Experiments have demonstrated that cryomilling is repeatable, and materials with reproducible chemistries and mechanical properties result. Furthermore, it is possible to vary the AlN content through control of the milling parameters. Tensile creep as well as compressive creep testing has been undertaken on a lot of NiAl-AlN. While this material is weaker in tension than compression, the tensile strength is respectable: for example, the creep rupture life exceeds 2700 h at 1300 K, 50 MPa. Heat treatment of the particulate reinforced aluminide at 1600 K promotes AlN growth which weakens the material but does not change the deformation mechanism. Cyclic oxidation testing of lots of NiAl-AlN which were cryomilled with and without yttria reveal that Y2O3 promotes better oxidation resistance. However, the presence or absence of yttria had no affect on the mechanical properties.
A fast Bayesian reconstruction algorithm for emission tomography with entropy prior converging to feasible images (1990)

The development and tests of an iterative reconstruction algorithm for emission tomography based on Bayesian statistical concepts are described. The algorithm uses the entropy of the generated image as a prior distribution, can be accelerated by the choice of an exponent, and converges uniformly to feasible images by the choice of one adjustable parameter. A feasible image has been defined as one that is consistent with the initial data (i.e. it is an image that, if truly a source of radiation in a patient, could have generated the initial data by the Poisson process that governs radioactive disintegration). The fundamental ideas of Bayesian reconstruction are discussed, along with the use of an entropy prior with an adjustable contrast parameter, the use of likelihood with data increment parameters as conditional probability, and the development of the new fast maximum a posteriori with entropy (FMAPE) Algorithm by the successive substitution method. It is shown that in the maximum likelihood estimator (MLE) and FMAPE algorithms, the only correct choice of initial image for the iterative procedure in the absence of a priori knowledge about the image configuration is a uniform field.