gebhart/patrepeval huggingface dataset:
Application of adaptive filters to noninvasive acoustical detection of coronary occlusions before and after angioplasty (1992)

Isolated diastolic heart sounds taken from recordings made at the patient's bedside were modeled using the autoregressive (AR) and autoregressive moving average (ARMA) methods after adaptive line enhancement (ALE). Decisions were made in a blind fashion without prior knowledge of whether a given recording was made before or after angioplasty. Resulting model frequency spectra showed greater high frequency components (between 400 and 800 Hz) in preangioplasty patients, and a consistent shift in amplitude of the second pole pairs of the AR and ARMA methods with surgery. Blind assessment based on frequency spectra and poles, correctly classified the diastolic recordings in 18 of 20 cases. These results provide evidence supporting the hypothesis that coronary stenoses produce detectable sounds during diastole.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Probability-based optimization of inter-sensing duration and power control in cognitive radio (2009)

Probability-based strategies are proposed in this letter to determine the optimal inter-sensing duration and power control for cognitive radio (CR). With utilization of the statistics of licensed band occupancy, appropriate inter-sensing duration is determined to capture the recurrence of spectrum opportunity in time when the licensed signal is detected, or to achieve the maximum spectrum efficiency under a certain level of interference with licensed communication when the licensed signal is declared absent. Transmit power is varied dynamically according to the non-interfering probability at each sample so as to increase the transmission rate and decrease the interference power.
Adhesion of lactobacilli to urinary catheters and diapers: Effect of surface properties (1994)

Thirteen strains of lactobacilli were tested for their ability to adhere to commercial devices used in the urinary tract. Although it appeared that the most hydrophilic organisms adhered in highest numbers, there was no significant correlation between water contact angle and adhesiveness to catheters. Five organisms tested were found to be highly adherent to Huggies commercial diapers. Loss in hydrophobicity upon serial culture of Lactobacillus fermentum B-54 was not due to a proteinaceous S layer, although protein involvement per se cannot be ruled out. It was evident that, not only can members of the normal female urogenital flora adhere to commonly used commercial prostheses, but their ability to attach is related to hydrophilic as well as hydrophobic surface components.
Multiple-invariant space-variant optical processors (1978)

Multiple invariant optical correlators are considered. By multiple invariance, we mean invariance to more than one distortion parameter per axis of the processor. Space variant optical processors using coordinate transformations and a new phase detection scheme are used to realize such correlators. A theoretical analysis and experimental verification are included.
Enhanced predictor–corrector Mars entry guidance approach with atmospheric uncertainties (2019)

Due to the long‐range data communication and complex Mars environment, the Mars lander needs to promote the ability to autonomously adapt uncertain situations ensuring high precision landing in future Mars missions. Based on the analysis of multiple disturbances, this study demonstrates an enhanced predictor–corrector guidance method to deal with the effect of atmospheric uncertainties during the entry phase of the Mars landing. In the proposed method, the predictor–corrector guidance algorithm is designed to autonomously drive the Mars lander to the parachute deployment. Meanwhile, the disturbance observer is designed to onboard estimate the effect of fiercely varying atmospheric uncertainties resulting from rapidly height decreasing. Then, with the estimation of atmospheric uncertainties compensated in the feed‐forward channel, the composite guidance method is put forward such that both anti‐disturbance and autonomous performance of the Mars lander guidance system are improved. Convergence of the proposed composite method is analysed. Simulations for a Mars lander entry guidance system demonstrates that the proposed method outperforms the baseline method in consideration of the atmospheric uncertainties.
An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy (2016)

<i>Francisella tularensis</i> is a highly virulent intracellular bacterium and cell-mediated immunity is critical for protection, but mechanisms of protection against highly virulent variants, such as the prototypic strain <i>F. tularensis</i> strain SCHU S4, are poorly understood. To this end, we established a co-culture system, based on splenocytes from naïve, or immunized mice and <i>in vitro</i> infected bone marrow-derived macrophages that allowed assessment of mechanisms controlling infection with <i>F. tularensis</i>. We utilized the system to understand why the <i>clpB</i> gene deletion mutant, Δ<i>clp</i>B, of SCHU S4 shows superior efficacy as a vaccine in the mouse model as compared to the existing human vaccine, the live vaccine strain (LVS). Compared to naïve splenocytes, Δ<i>clpB</i>-, or LVS-immune splenocytes conferred very significant control of a SCHU S4 infection and the Δ<i>clpB</i>-immune splenocytes were superior to the LVS-immune splenocytes. Cultures with the Δ<i>clpB</i>-immune splenocytes also contained higher levels of IFN-γ, IL-17, and GM-CSF and nitric oxide, and T cells expressing combinations of IFN-γ, TNF-α, and IL-17, than did cultures with LVS-immune splenocytes. There was strong inverse correlation between bacterial replication and levels of nitrite, an end product of nitric oxide, and essentially no control was observed when BMDM from iNOS<sup>-/-</sup> mice were infected. Collectively, the co-culture model identified a critical role of nitric oxide for protection against a highly virulent strain of <i>F. tularensis</i>.
Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy (2018)

Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational "hotspot" in the human <i>DMD</i> gene. We used adeno-associated viruses to deliver CRISPR gene editing components to four dogs and examined dystrophin protein expression 6 weeks after intramuscular delivery (<i>n</i> = 2) or 8 weeks after systemic delivery (<i>n</i> = 2). After systemic delivery in skeletal muscle, dystrophin was restored to levels ranging from 3 to 90% of normal, depending on muscle type. In cardiac muscle, dystrophin levels in the dog receiving the highest dose reached 92% of normal. The treated dogs also showed improved muscle histology. These large-animal data support the concept that, with further development, gene editing approaches may prove clinically useful for the treatment of DMD.
Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease (2017)

Antiviral responses are regulated by conjugation of ubiquitin (Ub) and interferon-stimulated gene 15 (ISG15) to proteins. Certain classes of viruses encode Ub- or ISG15-specific proteases belonging to the ovarian tumor (OTU) superfamily. Their activity is thought to suppress cellular immune responses, but studies demonstrating the function of viral OTU proteases during infection are lacking. Crimean-Congo hemorrhagic fever virus (CCHFV, family Nairoviridae) is a highly pathogenic human virus that encodes an OTU with both deubiquitinase and deISGylase activity as part of the viral RNA polymerase. We investigated CCHFV OTU function by inactivating protease catalytic activity or by selectively disrupting its deubiquitinase and deISGylase activity using reverse genetics. CCHFV OTU inactivation blocked viral replication independently of its RNA polymerase activity, while deubiquitinase activity proved critical for suppressing the interferon responses. Our findings provide insights into viral OTU functions and support the development of therapeutics and vaccines.
AIREAL (2013)

AIREAL is a novel haptic technology that delivers effective and expressive tactile sensations in free air, without requiring the user to wear a physical device. Combined with interactive computers graphics, AIREAL enables users to feel virtual 3D objects, experience free air textures and receive haptic feedback on gestures performed in free space. AIREAL relies on air vortex generation directed by an actuated flexible nozzle to provide effective tactile feedback with a 75 degrees field of view, and within an 8.5cm resolution at 1 meter. AIREAL is a scalable, inexpensive and practical free air haptic technology that can be used in a broad range of applications, including gaming, mobile applications, and gesture interaction among many others. This paper reports the details of the AIREAL design and control, experimental evaluations of the device's performance, as well as an exploration of the application space of free air haptic displays. Although we used vortices, we believe that the results reported are generalizable and will inform the design of haptic displays based on alternative principles of free air tactile actuation.
Cutting edge: evidence for ligand-independent multimerization of the IL-17 receptor (2007)

Kramer, J. M., L. Yi, F. Shen, A. Maitra, X. Jiao, T. Jin, and S. L. Gaffen. 2006. Cutting edge: evidence for ligand-independent multimerization of the IL-17 receptor. [ J. Immunol . 176: 711–715][1] . The authors incorrectly stated that the truncated IL-17RA FRET constructs extend from amino
Design and experimental results on a terawatt magnetically controlled plasma opening switch (1998)

The magnetically controlled plasma opening switch (MCPOS) is an advanced plasma opening switch that utilizes magnetic fields to improve operation. Magnetic fields always dominate terawatt, pulsed power plasma opening switches. For that reason, the MCPOS uses controlled applied magnetic fields with magnitude comparable to the self-magnetic field of the storage inductor. One applied field holds the plasma in place while energy accumulates in the storage inductor, then another applied field pushes the plasma away from the cathode to allow energy to flow downstream. Over a ten month period, an MCPOS was designed, built, and tested on DECADE Module 2 at Physics International. The peak drive current was 1.8 MA in 250 ns. The output parameters were up to 1 MA into an electron beam load. The radiation temporal pulse width averaged 60 nanoseconds full-width at half-maximum. The peak load voltage ranged from one to two megavolts. The experiments demonstrated efficient power flow through a long, low-impedance magnetically insulated transmission line between the magnetically controlled plasma opening switch and the load.
Output-based shared-memory crosspoint-buffered packet switch for multicast services (2007)

The incorporation of broadcast and multimedia-on-demand services are expected to increase multicast traffic in packet networks, and therefore in switches and routers. Combined input-crosspoint buffered (CICB) switches can provide high performance under uniform multicast traffic, however, at the expense of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> crosspoint buffers. In this letter, we propose an output-based shared-memory crosspoint-buffered (O-SMCB) packet switch where the crosspoint buffers are shared by two outputs and use no speedup. The proposed switch provides high performance under admissible uniform and nonuniform multicast traffic models while using 50% of the memory used in CICB switches. Furthermore, the O-SMCB switch provides higher throughput than an SMCB switch with buffers shared by inputs, or I-SMCB.
Air-core hollow optical waveguides with omnidirectional reflectors (2006)

We have designed and fabricated a hollow optical waveguide with omnidirectional reflectors (ODRs) on a silicon substrate. The pattern is defined by photolithography on a (100) silicon wafer. The groove is etched by inductive coupled plasma. Plasma-enhanced chemical vapor deposition technology is used to deposit six-pair Si/SiO2 (0.111/0.258 µm) multilayer stacks on the sample. Finally, the top of the sample is covered with an identical ODR. Hence, the light is confined in a hollow waveguide.
Combined Input-Crosspoint Buffered Packet Switch with Flexible Access to Crosspoints Buffers (2006)

The performance of Internet routers is greatly defined by the adopted switch architecture. Combined input-crosspoint buffered (CICB) packet switches are being considered of research interest because of their high switching performance. One of the main requirements in these switches is that the amount of memory needed to achieve 100% throughput under flows with high data rates must be proportional to the number of ports and crosspoint buffer size, which is set by the distance between the line cards and the buffered crossbar. Therefore, long distances between the line cards and the buffered crossbar can make a CICB switch costly to implement or infeasible. In this paper, we propose and discuss two CICB packet switches with flexible access to crosspoint buffers. The proposed switches allow an input to use any available crosspoint buffer at a given output, instead of having rigid access where an input can only access a dedicated crosspoint buffer at a given output, as is the case on previous existing architectures. The proposed switches provide high switching performance and support long distances between the buffered crossbar and the line cards, while using crosspoint buffers of small size. Our switches reduce the required crosspoint buffer size by a factor of TV, where TV is the number of ports, keep service of cells in sequence, and use no speedup
ChemInform Abstract: Regeneration of Ammonia Borane Spent Fuel by Direct Reaction with Hydrazine and Liquid Ammonia. (2011)

Abstract Polyborazylene which is formed by removal of more than two equivalents of H 2 per molecule from NH 3 ·BH 3 is converted back to ammonia borane nearly quantitatively by a 24‐hour treatment with N 2 H 4 in liquid NH 3 at 40 °C (sealed pressure vessel).
A Solid State Fermentation System for Production of Ethanol from Apple Pomace (1982)

ABSTRACT A solid state fermentation system for the production of ethanol from apple pomace with a Montrachet strain of Saccharomyces cerevisiae is described. The yields of ethanol varied from about 29g to more than 40g per kg of apple pomace, depending on the samples fermented. Separation of up to 99% of the ethanol from spent apple pomace was achieved with a rotary vacuum evaporator. The results of this study indicate that the alcoholic fermentation of apple pomace might be an efficient method of alleviating waste disposal problems with the concomitant production of ethanol.
Backup mainframe data to object storage systems (2019)

Mainframe systems backup and data archival is performed via proprietary data movement protocols to FICON-attached tape devices or virtual tape libraries using specialized backup software running on the mainframe operating system. These proprietary tape storage systems do not offer support for TCP/IP-attached storage solutions and for the standard protocols used to access these systems. The mainframe backup and archive software is tightly coupled with the tape architecture and by design writes data sets as a sequential, serial stream of data to tape. As the amounts of data in mainframe systems keep growing, the resource intensive backup and archive process become more expensive.
SnoRNAs as tools for RNA cleavage and modification. (1997)

Eukaryotic small nucleolar RNAs (snoRNAs) influence rRNA synthesis at two stages: nucleolytic processing and selection of nucleotides to be ribose methylated (Nm) or converted to pseudouridine (psi). The two modification functions and some processing activities involve direct base pairing of snoRNA with rRNA. In addition to rRNA-targeting sequences, snoRNA function depends on the presence of conserved box elements involved in snoRNA synthesis and localization. The present investigation is directed at using snoRNAs as tools for two purposes: 1) introducing nucleotide modifications into novel sites in rRNA and other snoRNAs, and: 2) targeting nucleolar RNAs for destruction using snoRNA:ribozyme chimers ('snorbozymes'). Early results demonstrate that snoRNAs can be used for both applications.
Ultra Wideband Pulse Shaper Design (2005)

This chapter contains sections titled: Introduction Transmit Spectrum and Pulse Shaper FIR Digital Pulse Design Optimal UWB Single Pulse Design Optimal UWB Orthogonal Pulse Design Design Examples and Comparisons Conclusions References
A noninvasive handheld assistive device to accommodate essential tremor: A pilot study (2013)

This noninvasive handheld ACT device can reduce tremor amplitude and severity for eating and transferring tasks in individuals with ET.
Glucose Degradation Products in Peritoneal Dialysis Fluids May Have Both Local and Systemic Effects: A Study of Residual Fluid and Mesothelial Cells (2001)

Low molecular weight carbonyls such as formaldehyde and methylglyoxal most probably react with the mesothelial cells lining the peritoneal cavity, and could be responsible for the disappearance of these cells during long-term treatment. 3-Deoxyglucosone showed remarkably low reactivity and was most probably transported within the patient.
Hybrid glass substrates for waveguide device manufacture (2001)

Hybrid glass substrates were prepared by a novel, low-temperature process joining active (Er-Yb codoped) and passive phosphate glass. The resulting hybrid substrates are chemically and physically robust; they can be cut, ground, and polished by conventional, water-based techniques. The entire substrate can be immersed in a molten-salt bath to produce waveguides simultaneously in the active and passive regions. A low reflectance of -34+/-2 dB was measured at the joint interface with 1531.2-nm light by optical low-coherence reflectometry. Further, a hybrid laser waveguide device exhibited a slope efficiency of 33% at 1540 nm when pumped at 975 nm.
An Adaptive Newton's Method for Reservoir Simulation (2011)

Abstract In trying to speed up reservoir simulators, we have given significant attention to improving runtime performance and efficiency on various components of the simulator, i.e. linear solvers, flash calculations, time-step controls, with further performance gain from parallelization. This paper describes an enhanced version of Newton's method, the adaptive Newton's method, that reduces time spent in nonlinear loops of a reservoir simulator. It is commonly observed that clusters of reservoir simulation cells are responsible for the convergence behavior within a Newton loop at a given timestep. In our investigations on field cases, the number of cells that had not converged, as defined by the magnitude of the residual and solution changes, would decease very rapidly as the Newton iteration progresses. In most cases, the number of unconverged cells was significantly less than 2% after just one or two Newton iterations. An adaptive nonlinear method was developed to use the residual of the previous Newton iteration as a guide to select a subset of cells for subsequent Newton iterations. The subset of cells includes all the unconverged cells plus a collection of bordering cells. Using this adaptation, the matrix solved at Newton iterations after the first one is very much reduced, resulting in significant speedup. Several variations in the adaption were investigated, varying the size of the border, varying the timing of the application of adaption and including a residual smoothing step. This adaptive Newton's method was applied to multiple field cases, with the numbers of simulation cells ranging from 14,000 to 900,000 cells. The use of the residual smoothing operator prevented material balance errors with minimal impact on the Newton convergence behavior and timestep sizes. Run times were reduced by 30~70 % in these field test cases with no negative effects on results.
PageRank Computation and the Structure of the Web: Experiments and Algorithms (2002)

We describe some computational experiments carried out with variants of the &quot;PageRank&quot; model due to Page et al., with particular reference to the small and large scale structure of the Web.
Voltage-mode grid-tie inverter with active power factor correction (2015)

Presented herein is a power and control system architecture of a voltage-mode inverter that is interfaced between a DC power source and an AC utility grid. Utilizing an inverter power stage of a full-bridge switching configuration, the single stage of DC-to-AC power conversion is innovatively controlled to achieve maximum power tracking from the power source and a driving sinusoidal output voltage with a proper phase-shift with respect to the utility grid voltage such that the utility grid current contains no reactive component at the utility grid frequency regardless of the load type (resistive, capacitive, or inductive). In addition to various protection features, a particular novel feature is the harmonic-cancellation capability that eliminates most or all of harmonic content in the inverter output voltage. The overall system of power and control results in either an in-phase (absorbing power) or out-of-phase (providing power) utility-grid current (unity power factor) with respect to the utility grid voltage while absorbing either maximum power available from the DC power source or limiting the delivered AC output power to not exceed either the inverter rated power or the maximum rated output voltage.
Compact high-power terahertz radiation source (2004)

In this paper a new type of THz radiation source, based on recirculating an electron beam through a high gradient superconducting radio frequency cavity, and using this beam to drive a standard electromagnetic undulator on the return leg, is discussed. Because the beam is recirculated and not stored, short bunches may be produced that radiate coherently in the undulator, yielding exceptionally high average THz power for relatively low average beam power. Deceleration from the coherent emission, and the detuning it causes, limits the charge-per-bunch possible in such a device.
Purification and analysis of the antigenicity of a 69000 Da protein from<i>Bordetella pertussis</i> (1990)

A purification scheme was devised for a 69-kDa outer membrane protein of Bordetella pertussis, a virulence-associated protein which may play a role in the pathogenesis of the organism. The protein was purified to apparent homogeneity by heating B. pertussis cells for 1 h at 60°C followed by DEAE-Sepharose and Affi-Gel Blue chromatography. Antibodies found in sera obtained from patients diagnosed as having pertussis reacted with this protein. This purification scheme should be useful for the production of the 69 kDa protein which is currently being evaluated as a pertussis vaccine candidate.
Callisto (2014)

It is increasingly important for parallel applications to run together on the same machine. However, current performance is often poor: programs do not adapt well to dynamically varying numbers of cores, and the CPU time received by concurrent jobs can differ drastically. This paper introduces Callisto, a resource management layer for parallel runtime systems. We describe Callisto and the implementation of two Callisto-enabled runtime systems---one for OpenMP, and another for a task-parallel programming model. We show how Callisto eliminates almost all of the scheduler-related interference between concurrent jobs, while still allowing jobs to claim otherwise-idle cores. We use examples from two recent graph analytics projects and from SPEC OMP.