gebhart/patrepeval huggingface dataset:
Facile Metalation of Silicon and Germanium Analogues of Thiocarboxylic Acids with a Manganese(II) Hydride Precursor (2012)

Synthesis and characterization of the first manganese(II)-containing heavier thiocarboxylate analogues, [L(Dip)Si(=S)OMnL(Dep)] (4; L(Dip)=CH[C(Me)N(2,6-iPr(2)C(6)H(3))](2), L(Dep)=CH[C(Me)N(2,6-Et(2)C(6)H(3))](2)) and [L(Dip)Ge(=S)OMnL(Dep)] (5) are described. They are accessible through reaction of the silicon and germanium analogues of the respective thiocarboxylic acids [L(Dip)E(=S)OH] (E=Si, Ge) with the β-diketiminato (nacnac) manganese(II) hydride precursor [(L(Dep)Mn)(2)(μ-H)(2)] (3) in high yield. The first Mn nacnac hydride 3 has been prepared by the reaction of manganese bromide [(L(Dep)Mn)(2)(μ-Br)(2)] (2) with KBEt(3)H. Compounds 4 and 5 represent the first transition-metal heavier thiocarboxylates with the Si=S and Ge=S functionalities. All new compounds are paramagnetic and were characterized by elemental analysis, IR spectroscopy, MS (EI), and single-crystal X-ray diffraction analyses. Due to the N→E (E=Si, Ge) and E=S→Mn donor-acceptor interaction as well as the carboxylate-like π-electron delocalization within the E(S)O moieties, the E=S double bonds in these compounds are resonance stabilized.
Systemic Delivery of an Oncolytic Adenovirus Expressing Soluble Transforming Growth Factor- <i>β</i> Receptor II–Fc Fusion Protein Can Inhibit Breast Cancer Bone Metastasis in a Mouse Model (2010)

We have investigated whether systemic delivery of an oncolytic adenovirus, Ad.sTβRFc, expressing the soluble form of transforming growth factor-β receptor II fused with human immunoglobulin Fc fragment (sTGFβRIIFc), could inhibit breast cancer bone metastasis in a mouse model. MDA-MB-231 (human breast cancer) cells were inoculated into the left heart ventricles of nude mice. Once the skeletal tumors were visible by X-rays, mice were intravenously injected with either buffer, Ad.sTβRFc, Ad(E1⁻).sTβRFc (a replication-deficient adenovirus expressing sTGFβRIIFc), or Ad.luc2 (a replicating adenovirus expressing firefly luciferase gene). On days 2 and 7 after viral injections, viral replication and sTGFβRIIFc expression were detected in the skeletal tumors in Ad.sTβRFc-treated group; only viral replication in Ad.luc2 group, and sTGFβRIIFc expression in the Ad(E1⁻).sTβRFc group, were detected. To examine the therapeutic effects, buffer or various viral vectors were administered on days 4 and 7 after intracardiac injection of MDA-MB-231 cells. On day 28, X-ray radiography showed a highly significant reduction in lesion size by Ad.sTβRFc, a significant reduction by Ad.luc2, and some reduction by Ad(E1⁻).sTβRFc. Goldner's trichrome and hematoxylin-eosin staining of the bone sections revealed a significant reduction of tumor burden in the Ad.sTβRFc group, but not in the Ad(E1⁻).sTβRFc or Ad.luc2 group. There were significant reductions in free calcium levels by Ad.sTβRFc, Ad(E1⁻).sTβRFc, and Ad.luc2; however, only in the Ad.sTβRFc group were calcium levels reduced to the normal values. These results suggest that concomitant viral replication and sTGFβRIIFc production are important to inhibit bone metastasis and osteolysis, and that Ad.sTβRFc could be developed for targeting breast cancer bone metastases.
On the coexistence of Wi-Fi and LTE-U in unlicensed spectrum (2017)

The deployment of long term evolution (LTE) in unlicensed spectrum (LTE-U) is a promising solution to overcome the spectrum shortage. However, the interaction between LTE-U and Wi-Fi in unlicensed spectrum has not been well understood. In this paper, we use stochastic geometry to develop a framework for the co-existence between LTE-U and Wi-Fi in unlicensed spectrum. To reduce the intra-and inter-RAT interference, LTE-U employs an ALOHA-like random access scheme and Wi-Fi performs carrier sensing and energy detection before transmission. We derive the retention probability and the coverage probability of Wi-Fi and LTE-U networks. Based on our analysis, we investigate the effect of network parameters on the coverage probability of these networks.
Vehicle-type identification through automated virtual loop assignment and block-based direction-biased motion estimation (2000)

This paper presents a method of automated virtual loop assignment and direction-based motion estimation. The unique features of our approach are that: 1) a number of loops are automatically assigned to each lane. The merit of doing this is that it accommodates pan-tilt-zoom actions without needing further human interaction; 2) the size of the virtual loops is much smaller for estimation accuracy; and 3) the number of virtual loops per lane is large. The motion content of each block may be weighted and the collective result offers a more reliable and robust approach in motion estimation. Comparing this with traditional inductive loop detectors, there are a number of advantages. Our simulation results indicate that the proposed method is effective in type classification.
Interfacial recombination velocity in GaAlAs/GaAs heterostructures (1978)

Photoluminescence time-decay measurements on Ga0.5Al0.5As/GaAs double heterostructures were made over a wide range of GaAs active layer thickness and doping levels at room temperature. Observed decay times τ in variously doped GaAs samples range from 10 to 450 nsec. Effects of self-absorption of luminescence and doping level are demonstrated for GaAs layer thickness d≳1 μm. For d&lt;1 μm, the observed decay times are nearly independent of doping level and vary almost linearly with d. The data are interpreted in terms of a small interfacial recombination velocity (Si=450±100 cm/sec) at the Ga0.5Al0.5As/GaAs interface. The value of Si determined here is an average over the doping levels examined.
Cultivation of hybridoma cells in continuous cultures: Kinetics of growth and product formation (1989)

Mouse hybridoma cells were grown in suspension in continuous stirred bioreactors. Cell growth, substrate utilization, and monoclonal antibody (MAb) production were studied using serum-free medium. Steady-state data were obtained at different dilution rates, between 0.012 and 0.039 h(-1) Viability was profoundly affected by dilution rate, particularly near the lower end of the dilution-rate range investigated. MAb concentration and productivity went through a maximum with respect to dilution rate. Lactate yield on glucose declined with increasing dilution rate. Experiments were carried out to study the effects of medium glucose concentration on cell growth, product formation, and lactate yield on glucose. Reduction of glucose concentration in the feed medium did not considerably affect cell density and MAb concentration in the culture, but lactate levels dropped sharply; lactate yield on glucose declined substantially, indicating alterations in cell metabolic path ways for energy metabolism. Optimization strategy for continuous cell culture is discussed.
Cisplatin resistance and ERCC1 gene regulation (2007)

4569 ERCC1 is a critical gene within the nucleotide excision repair pathway. Overexpression of ERCC1 through promoter-mediating transcription regulation is associated with repair of cisplatin-induced DNA damage and clinical resistance to platinum-chemotherapy. Several transcriptional repressors and activators within the 5’-flanking region of the ERCC1 gene may be involved in the up-regulation of this gene. Minimal promoter region analyzed by CAT assay demonstrated that the region from -220 to -110 was essential to constitutive expression of ERCC1 gene in ovarian cancer cell line A2780/CP70. A more forward upstream region seems to be responsible for cisplatin-induced expression. Identification of functional cis-element in this region by Electrophoretic Mobility Shift Assay revealed that an MZF1-like site as well as an AP1-like site responded to cisplatin stimulation with altered binding activities in a time-dependent manner. MZF1 mRNA in A2780/CP70 cells decreased upon cisplatin exposure as analyzed by real-time PCR, suggesting that MZF1 may mediate cisplatin-invoked gene expression in these cells. EMSA with MZF1 ZN1-4 consensus oligonucleotides suggests that the MZF1 N-terminal domain of zinc finger cluster may bind to the MZF1-like site of the ERCC1 promoter region. Overexpression of MZF1 could repress the ERCC1 promoter activity in a co-transfection assay, which further confirmed that MZF1 might be a repressor in regulation of ERCC1 transcription upon cisplatin exposure in A2780/CP70 cells. In summary, our studies revealed a core promoter region and adjacent drug-responsible region within the ERCC1 promoter. The drug-responsible region contains cis-elements of activator AP1 and repressor MZF1. In response to cisplatin treatment, decreased MZF1 and increased AP1 binding activities appear to be the leading mechanism of up-regulation of ERCC1 expression. Our findings suggest potential therapeutic strategies to antagonize cisplatin resistance in treatment of human ovarian cancer.
Chloroquine Increases Glucose Uptake via Enhancing GLUT4 Translocation and Fusion with the Plasma Membrane in L6 Cells (2016)

Our data indicate that chloroquine via Gβx03B3;-PLC-IP3-IP3R induces Ca2+ elevation, which in turn promotes GLUT4 fusion with the PM. Moreover, chloroquine can enhance GLUT4 trafficking to the PM. These mechanisms eventually result in glucose uptake increase in control and insulin-resistant L6 cells. These findings suggest that chloroquine might be a potential drug for improving insulin tolerance in diabetic patients.
Antitumor Effect of the Essential Oil from Leaves of <i>Guatteria pogonopus</i> (Annonaceae) (2013)

Guatteria pogonopus Martius, a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were γ-patchoulene (13.55%), (E)-caryophyllene (11.36%), β-pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), α-pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither (E)-caryophyllene nor β-pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC50 values ranged from 3.8 to 20.8 μg/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity.
Mo-O bond doping and related-defect assisted enhancement of photoluminescence in monolayer MoS<sub>2</sub> (2014)

In this work, we report a strong photoluminescence (PL) enhancement of monolayer MoS2 under different treatments. We find that by simple ambient annealing treatment in the range of 200 °C to 400 °C, the PL emission can be greatly enhanced by a factor up to two orders of magnitude. This enhancement can be attributed to two factors: first, the formation of Mo-O bonds during ambient exposure introduces an effective p-doping in the MoS2 layer; second, localized electrons formed around Mo-O bonds related defective sites where the electrons can be effectively localized with higher binding energy resulting in efficient radiative excitons recombination. Time resolved PL decay measurement showed that longer lifetime of the treated sample consistent with the higher quantum efficiency in PL. These results give more insights to understand the luminescence properties of the MoS2.
Risk factors in enterprise wide information management systems projects (2000)

In the past several years many organizations have initiated enterprise-wide information management systems projects, using such packages as SAP, Peoplesoft, and Oracle. These projects often represent the single largest investment in an information systems project in the history of these companies, and in many cases the largest single investment in any corporate-wide project. These enterprise-wide information management systems projects bring about a host of new questions, because they represent a new type of management challenge. Some of these questions and issues are:
Three-Dimensional Imaging of Sulfides in Silicate Rocks at Submicron Resolution with Multiphoton Microscopy (2011)

We report the first application of multiphoton microscopy (MPM) to generate three-dimensional (3D) images of natural minerals (micron-sized sulfides) in thick (∼120 μm) rock sections. First, reflection mode (RM) using confocal laser scanning microscopy (CLSM), combined with differential interference contrast (DIC), was tested on polished sections. Second, two-photon fluorescence (TPF) and second harmonic signal (SHG) images were generated using a femtosecond-laser on the same rock section without impregnation by a fluorescent dye. CSLM results show that the silicate matrix is revealed with DIC and RM, while sulfides can be imaged in 3D at low resolution by RM. Sulfides yield strong autofluorescence from 392 to 715 nm with TPF, while SHG is only produced by the embedding medium. Simultaneous recording of TPF and SHG images enables efficient discrimination between different components of silicate rocks. Image stacks obtained with MPM enable complete reconstruction of the 3D structure of a rock slice and of sulfide morphology at submicron resolution, which has not been previously reported for 3D imaging of minerals. Our work suggests that MPM is a highly efficient tool for 3D studies of microstructures and morphologies of minerals in silicate rocks, which may find other applications in geosciences.
Electrode modifications to lower electrode impedance and improve neural signal recording sensitivity (2015)

A controllable technology was developed to increase the effective surface area of electrodes using a CF4 plasma. Plasma-modified electrodes improved the quality of the neural probe recording and more sensitive to record spontaneous and evoked LFP in the ACC region.
Conditional Generative Model Based Predicate-Aware Query Approximation (2022)

The goal of Approximate Query Processing (AQP) is to provide very fast but "accurate enough" results for costly aggregate queries thereby improving user experience in interactive exploration of large datasets. Recently proposed Machine-Learning-based AQP techniques can provide very low latency as query execution only involves model inference as compared to traditional query processing on database clusters. However, with increase in the number of filtering predicates (WHERE clauses), the approximation error significantly increases for these methods. Analysts often use queries with a large number of predicates for insights discovery. Thus, maintaining low approximation error is important to prevent analysts from drawing misleading conclusions. In this paper, we propose ELECTRA, a predicate-aware AQP system that can answer analytics-style queries with a large number of predicates with much smaller approximation errors. ELECTRA uses a conditional generative model that learns the conditional distribution of the data and at run-time generates a small (≈ 1000 rows) but representative sample, on which the query is executed to compute the approximate result. Our evaluations with four different baselines on three real-world datasets show that ELECTRA provides lower AQP error for large number of predicates compared to baselines.
A Transportable Reflectarray Antenna for Satellite Ku-band Emergency Communications (2015)

The design of a Ku-band reconfigurable reflectarray antenna for emergency satellite communications is presented. Bidirectional high data rate satellite links are needed in emergency conditions where other telecommunication infrastructures are not available. In order to operate in this type of scenario, an antenna should be deployable, transportable, and easily repointable. The need of an automatic and fast satellite location and pointing system leads to a completely electronic reconfigurable antenna. The operative bandwidth is from 10.7 to 12.5 GHz for reception and from 14 up to 14.5 GHz for transmission (30% of relative bandwidth). The selected antenna architecture is based on a dual reflectarray system comprising a passive subreflectarray and an active main reflectarray made of reconfigurable 1-bit elementary cells based on PIN diodes.
Anomalous thermally stimulated currents and space charge in poly(vinyl pyrrolidone) (2000)

To study the mechanisms of charge production and storage in poly(vinyl pyrrolidone) (PVP), short circuit thermally stimulated currents (TSCs) in solution-grown PVP depolarized at 30, 50 and 80 °C with 25, 50 and 100 kV cm−1 have been analysed in the temperature range 30–200 °C. By employing TSC measurements with a conventional ‘contact electrode’ two kinds of charges have been observed. An anomalous TSC flowing in the same direction as the charging current was observed for PVP thermoelectrets poled at 50 and 80 °C with 50 and 100 kV cm−1. The TSCs for samples poled at different temperatures (30, 50 and 80 °C) with 25 kV cm−1 have been found to be normal in the sense that the discharge current flows in the direction opposite to that of the charging current. The TSC thermograms have been found to be characterized by two peaks located at 60–70 °C and 160–170 °C. Various characteristics of thermograms have been explained in terms of the existence of heterocharge due to dipolar orientation and ionic homocharge drift, together with the injection of charge carriers from electrodes and their subsequent localization in surface and bulk traps. © 2000 Society of Chemical Industry
Reinforcement Learning for Spoken Dialogue Systems (1999)

Recently, a number of authors have proposed treating dialogue systems as Markov decision processes (MDPs). However, the practical application of MDP algorithms to dialogue systems faces a number of severe technical challenges. We have built a general software tool (RLDS, for Reinforcement Learning for Dialogue Systems) based on the MDP framework, and have applied it to dialogue corpora gathered from two dialogue systems built at AT&amp;T Labs. Our experiments demonstrate that RLDS holds promise as a tool for &quot;browsing&quot; and understanding correlations in complex, temporally dependent dialogue corpora. 1 Introduction Systems in which human users speak to a computer in order to achieve a goal are called spoken dialogue systems. Such systems are some of the few realized examples of openended, real-time, goal-oriented interaction between humans and computers, and are therefore an important and exciting testbed for AI and machine learning research. Spoken dialogue systems typically integrate ma...
基于混沌理论探讨太极拳运动对高血压的防治作用 (2014)

In this paper, review and analysis of the fluctuations of blood pressure and pathogenesis of hypertension were presented a review and analysed based on chaos theory. At the same time, we interpreted philosophically the special concept of Tai Chi Chuan Exercise. Furthermore, the possible mechanisms of prevention and treatment of Tai Chi Chuan on hypertension was reviewed on the basis of clinical research literature.
State and Role of Src Family Kinases in Replication of Herpes Simplex Virus 1 (2006)

An earlier report showed that infected cell protein no. 0 (ICP0) of herpes simplex virus 1 (HSV-1) interacts with the SH3 domains of a recently discovered adaptor protein, CIN85. Here, we report the following. (i) ICP0 also interacts with other SH3 domain-containing proteins and, in particular, with nonneuronal members of the Src kinase family. (ii) HSV-1 infection enhanced the activating phosphorylation of Tyr416 of the members of the Src kinase family, modestly enhanced the kinase activity of Src, and posttranslationally modified at least one additional member of the Src kinase family by phosphorylation in a manner dependent on the viral gene products ICP0, unique short 3 (U(S)3), and unique long 13 (U(L)13). (iii) To define the roles of Src kinase family members, we examined the accumulation of viral proteins, DNA, and mRNA and virus yields from wild-type mouse embryo fibroblasts and sibling cells lacking Src, Fyn, and Yes (SYF-); a mutant cell line, +Src, in which Src was restored to SYF- cells; and the mutant cell line (CSK-) lacking the negative regulator Csk gene of the Src kinase family. Representative alpha, beta, and gamma2 proteins accumulated in the largest amounts in SYF- cells and the smallest amounts in +Src compared to wild-type cells. The CSK- cells yielded smaller amounts of the gamma2 protein and at least 10-fold less virus than wild-type cells. We conclude that HSV-1 proteins regulate the activities of Src family kinases to achieve optimal viral yields in the course of viral replication.
Human T‐ and B‐Cell Reactivity to the 16 kDa α‐Crystallin Protein of <i>Mycobacterium tuberculosis</i> (1998)

The attributes of immunodominance, predominant expression during mycobacterial dormancy and restriction to the Mycobacterium tuberculosis complex make the 16 kDa protein an important candidate for the study of the immune response in humans. We therefore investigated the relationship between T- and B-cell reactivity to the recombinant antigen and disease in a total of 127 subjects. The percentage of T-cell responders towards both the intact antigen and its permissively recognised peptide 16p91-110 was highest in healthy bacillus Calmette-Guérin (BCG)-sensitized controls (96% and 68%, respectively) and lowest in those with extensive untreated tuberculosis (26% and 18%) (P < 0.001). By contrast, antibody levels (ABT50 > 100) were highest in patients with extensive disease (46-50%) (P < 0.005). There was significantly higher production of IFN-gamma in the BCG-sensitized controls by comparison with untreated patients (P < 0.05), but complete antituberculous chemotherapy abolished this deficit in patients. The significance of these findings to immunodiagnosis and protective immunity is discussed.
Reservoir computing with a single time-delay autonomous Boolean node (2015)

We demonstrate reservoir computing with a physical system using a single autonomous Boolean logic element with time-delay feedback. The system generates a chaotic transient with a window of consistency lasting between 30 and 300 ns, which we show is sufficient for reservoir computing. We then characterize the dependence of computational performance on system parameters to find the best operating point of the reservoir. When the best parameters are chosen, the reservoir is able to classify short input patterns with performance that decreases over time. In particular, we show that four distinct input patterns can be classified for 70 ns, even though the inputs are only provided to the reservoir for 7.5 ns.
Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy (2014)

Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. To address this problem, we used a systems-based discovery strategy to search for a small molecule whose mRNA expression signature negatively correlates to mRNA expression signatures of human skeletal muscle atrophy. This strategy identified a natural small molecule from tomato plants, tomatidine. Using cultured skeletal myotubes from both humans and mice, we found that tomatidine stimulated mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and ultimately, cell growth. Furthermore, in mice, tomatidine increased skeletal muscle mTORC1 signaling, reduced skeletal muscle atrophy, enhanced recovery from skeletal muscle atrophy, stimulated skeletal muscle hypertrophy, and increased strength and exercise capacity. Collectively, these results identify tomatidine as a novel small molecule inhibitor of muscle atrophy. Tomatidine may have utility as a therapeutic agent or lead compound for skeletal muscle atrophy.