gebhart/patrepeval huggingface dataset:
Factors Affecting the Methanogenic Activity of <i>Methanothrix soehngenii</i> VNBF (1987)

Methane production by Methanothrix soehngenii VNBF grown on acetate (50 mM) as the sole carbon and energy source was influenced by the addition of Fe, trace elements, and pesticides. The addition of Fe and trace elements significantly enhanced the rate of CH(4) production. The addition of pesticides in the early growth phase caused complete inhibition. However, less inhibition was noted when pesticides were added during early exponential growth phase. Addition to culture tubes of Co, Ni, or Mo at 2 muM produced 64, 41, or 17%, respectively, more CH(4) than that produced in tubes lacking the corresponding trace element. A concentration of more than 5 muM of these trace elements in the medium resulted in decreased CH(4) production, presumably because of toxic effects.
Revealing real quality of double compressed MP3 audio (2010)

MP3 is the most popular format for audio storage and a de facto standard of digital audio compression for the transfer and playback. The flexibility of compression ratio of MP3 coding enables users to choose their customized configuration in the trade-off between file size and quality. Double MP3 compression often occurs in audio forgery, steganography and quality faking by transcoding an MP3 audio to a different compression ratio. To detect double MP3 compression, in this paper, we extract the statistical features on the modified discrete cosine transform, and apply support vector machines and a dynamic evolving neuron-fuzzy inference system to the extracted features for classification. Experimental results show that our method effectively and accurately detects double MP3 compression for both up-transcoded and down-transcoded MP3 files. Our study also indicates the potential for mining the audio processing history for forensic purposes.
Buchwald–Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N-Heterocyclic Carbene/Palladium(II) Precatalyst (2015)

The cross-coupling of aryl tosylates with amines and anilines was achieved by using for the first time a Pd-NHC system based on the popular Pd-PEPPSI precatalyst platform in which the anchoring imidazol-2-ylidene ligand IPr((NMe2)2) incorporates two dimethylamino groups as backbone substituents enhancing both the electronic and steric properties of the carbene. The system optimization and its application scope are disclosed.
Heterologous Protein Secretion Directed by a Repressible Acid Phosphatase System of <i>Kluyveromyces lactis</i> : Characterization of Upstream Region-Activating Sequences in the <i>KIPHO5</i> Gene (1998)

Transcription of the repressible acid phosphatase gene (KIPHO5) in Kluyveromyces lactis is strongly regulated in response to the level of inorganic phosphate (Pi) present in the growth medium. We have begun a study of the promoter region of this gene in order to identify sequences involved in the phosphate control of KIPHO5 expression and to design new expression-secretion systems in K. lactis. Deletion analysis and directed mutagenesis revealed two major identical upstream activating sequences (UAS) CACGTG at positions -430 (USA1) and -192 (UAS2) relative to the ATG initiation codon. These sequences are identical to those described for Saccharomyces cerevisiae for the binding of Pho4p. Deletion or directed mutagenesis of either one or both UAS reduce KIPHO5 expression by the same amount (approximately 80%). When fused to the coding region of trout growth hormone cDNA (tGH-II), the promoter and signal peptide-encoding region of the phosphate-repressible KIPHO5 gene drives the expression of this gene and the secretion of the tGHII protein. Synthesis of tGHIIp in K. lactis transformants carrying this construct was found to be regulated by the Pi present in the medium; depression of heterologous protein expression can therefore be achieved by lowering the Pi concentration.
Shoring up persistent applications (1994)

SHORE (Scalable Heterogeneous Object REpository) is a persistent object system under development at the University of Wisconsin. SHORE represents a merger of object-oriented database and file system technologies. In this paper we give the goals and motivation for SHORE, and describe how SHORE provides features of both technologies. We also describe some novel aspects of the SHORE architecture, including a symmetric peer-to-peer server architecture, server customization through an extensible value-added server facility, and support for scalability on multiprocessor systems. An initial version of SHORE is already operational, and we expect a release of Version 1 in mid-1994.
Low-frequency noise impact on CMOS image sensors (2009)

CMOS image sensors are nowadays extensively used in imaging applications even for high-end applications. This is really possible thanks to a reduction of noise obtained, among others, by Correlated Double Sampling (CDS) readout. Random Telegraph Signal (RTS) noise has thus become an issue for low light level applications especially in the context of downscaling transistor size. This paper describes the analysis of in-pixel source follower transistor RTS noise filtering by CDS circuit. The measurement of a non Gaussian distribution with a positive skew of image sensor output noise is analysed. Impact of dimensions (W and L) of the in-pixel source follower is demonstrated. Circuit to circuit pixel output noise dispersion on 12 circuits coming from 3 different wafers is also analysed and weak dispersion is seen.
Effect of positive inotropic agents on the relation between oxygen consumption and systolic pressure volume area in canine left ventricle. (1983)

We analyzed the effect of positive inotropic agents on the relation between left ventricular oxygen consumption and the systolic pressure-volume area. Pressure-volume area is a measure of total mechanical energy for ventricular contraction, and is a specific area in the ventricular pressure-volume diagram circumscribed by the end-systolic and end-diastolic pressure-volume relation curves and the systolic segment of the pressure-volume trajectory. Either epinephrine (1 microgram/kg per min, iv) or calcium ion (0.03 mEq/kg per min, iv) was administered to canine excised cross-circulated hearts. These agents increased an index of ventricular contractility, Emax, or the slope of the end-systolic pressure-volume line, by 70%. The regression lines of ventricular oxygen consumption on pressure-volume area in control and in enhanced contractile states were of the same formula: ventricular oxygen consumption (ml O2/beat per 100 g) equals A times pressure-volume area (mm Hg ml/beat per 100 g) plus a constant B. Coefficient A remained unchanged at 1.8 X 10(-5) ml oxygen/(mm Hg ml), but constant B increased from 0.03 ml oxygen/beat per 100 g by more than 50% with either agent. The reciprocal of A reflects the energy conversion efficiency for the total mechanical energy, and this efficiency remained near 36%. The increase in B was equal to the directly measured increment in ventricular oxygen consumption for mechanically unloaded contraction. The basal metabolism remained unchanged. We conclude that the augmented oxygen consumption under the acutely enhanced contractile state with either epinephrine or calcium was caused primarily by an increased energy utilization associated with the excitation-contraction coupling.
Recent Developments in Peptide-Based Nucleic Acid Delivery (2008)

Despite the fact that non-viral nucleic acid delivery systems are generally considered to be less efficient than viral vectors, they have gained much interest in recent years due to their superior safety profile compared to their viral counterpart. Among these synthetic vectors are cationic polymers, branched dendrimers, cationic liposomes and cell-penetrating peptides (CPPs). The latter represent an assortment of fairly unrelated sequences essentially characterised by a high content of basic amino acids and a length of 10-30 residues. CPPs are capable of mediating the cellular uptake of hydrophilic macromolecules like peptides and nucleic acids (e.g. siRNAs, aptamers and antisense-oligonucleotides), which are internalised by cells at a very low rate when applied alone. Up to now, numerous sequences have been reported to show cell-penetrating properties and many of them have been used to successfully transport a variety of different cargos into mammalian cells. In recent years, it has become apparent that endocytosis is a major route of internalisation even though the mechanisms underlying the cellular translocation of CPPs are poorly understood and still subject to controversial discussions. In this review, we will summarise the latest developments in peptide-based cellular delivery of nucleic acid cargos. We will discuss different mechanisms of entry, the intracellular fate of the cargo, correlation studies of uptake versus biological activity of the cargo as well as technical problems and pitfalls.
Locally enhanced Voronoi cell finite element model (LE‐VCFEM) for simulating evolving fracture in ductile microstructures containing inclusions (2008)

Abstract Ductile heterogeneous materials such as cast aluminum alloys undergo catastrophic failure that initiates with particle fragmentation, which evolves with void growth and coalescence in localized bands of intense plastic deformation and strain softening. The Voronoi cell finite element model (VCFEM), based on the assumed stress hybrid formulation, is unable to account for plastic strain‐induced softening. To overcome this shortcoming of material softening due to plastic strain localization, this study introduces a locally enhanced VCFEM (LE‐VCFEM) for modeling the very complex phenomenon of ductile failure in heterogeneous metals and alloys. In LE‐VCFEM, finite deformation displacement elements are adaptively added to regions of localization in the otherwise assumed stress‐based hybrid Voronoi cell finite element to locally enhance modeling capabilities for ductile fracture. Adaptive h ‐refinement is used for the displacement elements to improve accuracy. Damage initiation by particle cracking is triggered by a Weibull model. The nonlocal Gurson–Tvergaard–Needleman model of porous plasticity is implemented in LE‐VCFEM to model matrix cracking. An iterative strain update algorithm is used for the displacement elements. The LE‐VCFEM code is validated by comparing with results of conventional FE codes and experiments with real materials. The effect of various microstructural morphological characteristics is also investigated. Copyright © 2008 John Wiley & Sons, Ltd.
NF-κB activation enhances cell death by antimitotic drugs in human prostate cancer cells (2010)

Our data suggest that the combination of antimitotic drugs with NF-kappaB inhibitors will have antagonistic effects in a common type of PC cell typical of LNCaP. However, combination strategies utilizing antimitotic drugs with BA, an activator of NF-kappaB, will universally enhance cell death in PC cells, notably in the aggressive, castration-resistant variety that does not respond to conventional therapies.
Peptide-Based SAMs that Resist the Adsorption of Proteins (2008)

In this paper we present a modular approach for the fabrication of surfaces to characterize protein-protein interactions. The approach is based on azido peptides with an optimized sequence which are then thiol-functionalized using an alkynyl thiol and "click" chemistry. From these peptide thiols we fabricated SAMs on gold to evaluate the protein resistance, using surface plasmon resonance spectroscopy, toward streptavidin, bovin serum albumin (BSA), and fibronectin.
Effect of Crystallinity on Electrical Conductivity of &alpha; Cu-Phthalocyanine Film (1992)

In order to know the effect of crystallinity on electrical conductivity of α Cu-Phthalocyanine (CuPc), the thin films were formed on the glass substrate cleaned with ethyl alcohol in the ultrasonic washer, by means of the vacuum evaporation method. The crystallinity of the thin film was modified by the variation of the substrate temperature. The substrate temperature was changed over a range from -160 to 40°C by heating it with a electric heater and cooling it with the liquid nitrogen. As a results, α CuPc thin films were obtained in the range of the degree of crystallinity from 15 to 60%. The crystallinity of CuPc decreased with decreasing the substrate temperature. Electrical conduction was measured at room temperature in a vacuum vessel by applying the dc voltage. The electrical resistivity in the parallel direction to the substrate, decreased gradually and that in the vertical direction to the substrate, increased gradually with decreasing the degree of crystallinity. It would be surmised that these results is due to a variation of the mobility of, π-electron as a charge carrier in α CuPc.
Optimal conditional ARIMA forecasts (1989)

Abstract An optimal univariate forecast, based on historical and additional information about the future, is obtained in this paper. Its statistical properties, as well as some inferential procedures derived from it, are indicated. Two main situations are considered explicitly: (1) when the additional information imposes a constraint to be fulfilled exactly by the forecasts and (2) when the information is only a conjecture about the future values of the series or a forecast from an alternative model. Theoretical and empirical illustrations are provided, and a unification of the existing methods is also attempted.
A Scalable Collaborative Online System for City Reconstruction (2013)

Recent advances in Structure-from-Motion and Bundle Adjustment allow us to efficiently reconstruct large 3D scenes from millions of images. However, acquiring the imagery necessary to reconstruct a whole city and not only its landmark buildings still poses a tremendous problem. In this paper, we therefore present an online system for collaborative city reconstruction that is based on crowdsourcing the image acquisition. Employing publicly available building footprints to reconstruct individual blocks rather than the whole city at once enables our system to easily scale to large urban environments. In order to map all partial reconstructions into a single coordinate frame, we develop a robust alignment scheme that registers the individual point clouds to their corresponding footprints based on GPS coordinates. Our approach can handle noise and outliers in the GPS positions and allows us to detect wrong alignments caused by the typical issues in the context of crowdsourcing applications such as malicious or improper image uploads. Furthermore, we present an efficient rendering method to obtain dense and textured views of the resulting point clouds without requiring costly multi-view stereo methods.
Mechanisms of Stiffening and Strengthening in Media-Equivalents Fabricated Using Glycation (2000)

We have recently reported that glycation can be exploited to increase the circumferential tensile stiffness and ultimate tensile strength of media-equivalents (MEs) and increase their resistance to collagenolytic degradation, all without loss of cell viability (Girton et al., 1999). The glycated MEs were fabricated by entrapping high passage adult rat aorta SMCs in collagen gel made from pepsin-digested bovine dermal collagen, and incubated for up to 10 weeks in complete medium with 30 mM ribose added. We report here on experiments showing that ME compaction due to traction exerted by the SMCs with consequent alignment of collagen fibrils was necessary to realize the glycation-mediated stiffening and strengthening, but that synthesis of extracellular matrix constituents by these cells likely contributed little, even when 50 micrograms/ml ascorbate was added to the medium. These glycated MEs exhibited a compliance similar to arteries, but possessed less tensile strength and much less burst strength. MEs fabricated with low rather than high passage adult rat aorta SMCs possessed almost ten times greater tensile strength, suggesting that alternative SMCs sources and biopolymer gels may yield sufficient strength by compositional remodeling prior to implantation in addition to the structural remodeling (i.e., circumferential alignment) already obtained.
Changes in voltage‐operated calcium channels modify ethanol withdrawal hyperexcitability in mouse hippocampal slices (1993)

Measurements of hippocampal excitability were made from area CA1 of isolated mouse hippocampal slices, prepared after chronic ethanol treatment in vivo, and the effects of the stereoisomers of the dihydropyridine Bay K 8644, that act at calcium channels, were investigated. The decrease in the threshold stimulation required to produce a single population spike, the leftward shift in the population spike input-output curves, and the increase in population spike amplitude, that were seen during ethanol withdrawal, were all increased by the (-) isomer of Bay K 8644. This isomer has been shown to increase opening of calcium channels. These effects of ethanol withdrawal were decreased by the (+) isomer of Bay K 8644, that is a calcium channel blocker. In contrast, the increase in paired-pulse potentiation of the population spike, seen during the initial phase of ethanol withdrawal, was significantly decreased by both isomers of Bay K 8644. After the chronic ethanol treatment, single orthodromic stimuli produced epileptiform field potentials, consisting of two independent phases, a short latency series of multiple population spikes, superimposed upon the initial observed EPSP, and a longer latency train of spikes, occurring on a second EPSP, temporally distinct from the first. The (-) isomer of Bay K 8644 increased both these phases of epileptiform activity during ethanol withdrawal in a dose-dependent manner, while (+)-Bay K 8644 reduced the initial phase of multiple spiking and abolished the later phase. In slices from control animals, the higher concentration of (-)-Bay K 8644 (2 microM), but not the lower concentration (500 nM) decreased the stimulation required to produce multiple population spikes. Neither produced the long latency epileptiform activity. The (+) isomer of Bay K 8644 had no effect on control recordings. Lesioning the Schaffer collateral-commissural fibre pathway, or removing area CA3, in slices from ethanol-treated animals, abolished the later phase of epileptiform activity without affecting the initial multiple spiking. Intracellular recordings from area CA1 showed both the short latency and the longer latency epileptiform activities in slices from ethanol-treated mice and in control hippocampal slices after application of the (-) isomer of Bay K 8644, but these patterns of activity were not seen in control slices in the absence of Bay K 8644. Spontaneous activity during ethanol withdrawal was seen in intracellular recordings, but such activity was not seen in the field potential recordings.(ABSTRACT TRUNCATED AT 400 WORDS)
Headache, numbness and weakness of left limbs (2016)

<strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.12.012
Measurement Of Long Radius Of Curvature (1983)

Several methods for the measurement of very long radius of curvature of a convex or concave spherical mirror are reviewed in this paper. These methods have relevance in the measurement of the radii of curvature of laser mirrors. The accuracies achievable with the various methods are compared and summarized.
Blockade of GABA receptors in superior colliculus protects against focally evoked limbic motor seizures (1993)

Blockade of GABA receptors in the rat superior colliculus (SC) has been shown to protect against maximal electroshock-induced tonic convulsions and spontaneous generalized non-convulsive seizures. In the present study, we determined that blockade of GABA receptors in SC could also protect against focally evoked limbic motor seizures. Limbic motor seizures were induced by the unilateral focal application of bicuculline methiodide into area tempestas (AT), an epileptogenic site in the deep prepiriform cortex. Control rats (receiving bilateral infusions of saline into SC) all exhibited convulsive seizures following bicuculline in AT. Rats pretreated (5 min before) with bicuculline (50 pmol) bilaterally in the deep layers of the SC, were protected against the AT-evoked convulsive seizures. Unilateral application of bicuculline in the deep SC or bilateral application in the superficial layers of the SC did not alter the convulsive response to bicuculline in AT. These results indicate that the anticonvulsant action of GABA blockade in SC is not limited to tonic convulsive seizures but extends to the clonic manifestations evoked by seizures originating in forebrain limbic circuits. Given that the deep layers of SC receive inputs from GABA neurons in substantia nigra and that suppression of the activity of nigral neurons is anticonvulsant against a variety of seizures (including those evoked from AT), it is likely that the anticonvulsant action of bicuculline in SC is due to interference with the influence of a nigrotectal GABAergic projection.
Electro−optic intensity modulation in LiTaO3 ridge waveguide (1975)

A narrow rectangular ridge for 24 μm (width of the top) ×6 μm (height) ×5.4 mm (length) has been formed on Cu−diffused x−plate LiTaO3 using the sputter−etching technique. The intensity modulation of the optical wave confined in the ridge has been made up to 1 GHz with a half−wave voltage of 25−30 V at 6328 Å.
Drive systems with permanent magnet synchronous motors (1995)

This article reports that simulations indicate that a 15% longer electric-vehicle driving range is possible with permanent magnet synchronous motor drive systems compared with asynchronous types. The simplified driveline made possible by a permanent magnet design more than offsets its extra cost. A number of electric-motor types are suitable for electric-vehicle drive systems, one being the permanent magnet (PM) motor. The available of powerful PM materials, the choice of a high number of poles, and the possibility of field weakening are all essential factors for high-performance PM motors. Except for the magnets, PM motor designs are similar to other types of ac motors, and can use the same inverters as other ac motors. Tests and simulations of vehicle drive cycles have indicated that a substantially greater driving range is possible when PM motor drive systems are used. Due to the magnets, the cost of such systems is somewhat higher, but this can be compensated for by improved performance and simplified installation.
Kognition, evolution og Bibel (2014)

Teorier om biokulturel evolution og aksetid, fx som hos Robert Bellah, er et lovende fremtidigt forskningsfelt også for Bibelfaget
Cross-narrative Temporal Ordering of Medical Events (2014)

Cross-narrative temporal ordering of medical events is essential to the task of generating a comprehensive timeline over a patient's history. We address the problem of aligning multiple medical event sequences, corresponding to different clinical narratives, comparing the following approaches: (1) A novel weighted finite state transducer representation of medical event sequences that enables composition and search for decoding, and (2) Dynamic programming with iterative pairwise alignment of multiple sequences using global and local alignment algorithms. The cross-narrative coreference and temporal relation weights used in both these approaches are learned from a corpus of clinical narratives. We present results using both approaches and observe that the finite state transducer approach performs performs significantly better than the dynamic programming one by 6.8% for the problem of multiple-sequence alignment.