gebhart/patrepeval huggingface dataset:
The DIF1 gene of Arabidopsis is required for meiotic chromosome segregation and belongs to the REC8/RAD21 cohesin gene family (1999)

Cohesins are a group of conserved proteins responsible for cohesion between replicated sister chromatids during mitosis and meiosis and which are implicated in double-strand break repair and meiotic recombination. We describe here the identification and characterisation of an Arabidopsis gene - DETERMINATE, INFERTILE1 (DIF1), which is a homolog of the Schizosaccharomyces pombe REC8/RAD21 cohesin genes, and is essential for meiotic chromosome segregation. Five independent alleles of the DIF1 gene were isolated by transposon mutagenesis, and the mutants show complete male and female sterility. Pollen mother cells (PMCs) of dif1 mutants show multiple meiotic defects which are represented by univalent chromosomes and chromosome fragmentation at metaphase I, and acentric fragments and chromatin bridges in meiosis I and II. Consequently, chromosome segregation is strongly affected, resulting in meiotic products of uneven size, shape and of variable ploidy. The similarities in phenotype, and the sequence homology between DIF1 and the REC8/RAD21 cohesins suggests that cohesin function is largely conserved between eukaryotes and highlights the essential role cohesins play in plant meiosis.
Role of the Colorless Polypeptides in Phycobilisome Assembly in <i>Nostoc</i> sp. (1983)

We have identified the function of the ;extra' polypeptides involved in phycobilisome assembly in Nostoc sp. These phycobilisomes, as those of other cyanobacteria, are composed of an allophycocyanin core, phycoerythrin- and phycocyanin-containing rods, and five additional polypeptides of 95, 34.5, 34, 32, and 29 kilodaltons. The 95 kilodalton polypeptide anchors the phycobilisome to the thylakoid membrane (Rusckowski, Zilinskas 1982 Plant Physiol 70: 1055-1059); the 29 kilodalton polypeptide attaches the phycoerythrin- and phycocyanin-containing rods to the allophycocyanin core (Glick, Zilinskas 1982 Plant Physiol 69: 991-997). Two populations of rods can exist simultaneously or separately in phycobilisomes, depending upon illumination conditions. In white light, only one type of rod with phycoerythrin and phycocyanin in a 2:1 molar ratio is synthesized. Associated with this rod are the 29, 32, and 34 kilodalton colorless polypeptides; the 32 kilodalton polypeptide links the two phycoerythrin hexamers, and the 34 kilodalton polypeptide attaches a phycoerythrin hexamer to a phycocyanin hexamer. The second rod, containing predominantly phycocyanin, and the 34.5 and 29 kilodalton polypeptides, is synthesized by redlight-adapted cells; the 34.5 kilodalton polypeptide links two phycocyanin hexamers. These assignments are based on isolation of rods, dissociation of these rods into their component biliproteins, and analysis of colorless polypeptide composition, followed by investigation of complexes formed or not formed upon their recombination.
Edge detection with iteratively refined regularization (2002)

An approach to edge detection problems using regularization theory is presented. The energy functional in the standard regularization has been modified to control the smoothness over the image spatially in order to obtain accurate location of edges. An algorithm which iteratively improves the solution in discontinuous regions by updating the space-varying regularization parameter has been developed. The regularization parameter is controlled by features extracted from the error signal between the regularized solution obtained in the previous iteration and the image data. The algorithm smooths the noisy image without degrading discontinuities. It offers computational advantages and an efficient alternative to existing algorithms for edge detection and for surface reconstruction. The application of the proposed algorithm to various synthetic and real images is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Glucose control in intensive care: usability, efficacy and safety of Space GlucoseControl in two medical European intensive care units (2014)

SGC is a safe and efficient method to control blood glucose in critically ill patients as assessed in two European medical intensive care units.
VIP and PACAP are autocrine factors that protect the androgen‐independent prostate cancer cell line PC‐3 from apoptosis induced by serum withdrawal (2003)

1. In the present study, we describe the expression of the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) as well as their receptors in PC-3 cells, a human prostate cancer cell line. In addition, we have investigated their role in apoptosis induced by serum starvation. 2. By RT-PCR and immunocytochemistry assays, we have demonstrated the production of VIP and PACAP in PC-3 cells. 3. We have demonstrated by RT-PCR and binding assays the expression of common PACAP/VIP (VPAC(1) and VPAC(2)) receptors, but not PACAP-specific (PAC(1)) receptors. The pharmacological profile of [(125)I]-VIP binding assays was as follows: VPAC(1) antagonist=VPAC(1) agonist>VIP>VPAC(2) agonist (IC(50)=1.2, 1.5, 2.3 and 30 nM, respectively). In addition, both receptor subtypes are functional since VIP, PACAP-27 or VPAC(1) and VPAC(2) agonists all increased the intracellular levels of cAMP. 4. The expression of both peptides and their receptors is similar in serum-cultured and serum-deprived PC-3 cells. The treatment of serum-deprived PC-3 cells with exogenous VIP or PACAP-27 increases cell number and viability in a dose-dependent manner, as demonstrated by cellular counting and MTT assays. The increased cell survival is exerted through the VPAC(1) receptor, since a VPAC(1), but not VPAC(2), receptor agonist, mimics the effects and a VPAC(1) receptor antagonist blocks it. Moreover, VIP and PACAP-27 inhibit genomic DNA fragmentation in PC-3 cells triggered by serum starvation, and increase the immunoreactivity of the antiapoptotic protein bcl-2. 5. Our results suggest that VIP and PACAP are autocrine/paracrine factors that protect PC-3 cells from apoptosis through VPAC1 receptors.
Nonintrusive Load Monitoring Based on Advanced Deep Learning and Novel Signature (2017)

Monitoring electricity consumption in the home is an important way to help reduce energy usage. Nonintrusive Load Monitoring (NILM) is existing technique which helps us monitor electricity consumption effectively and costly. NILM is a promising approach to obtain estimates of the electrical power consumption of individual appliances from aggregate measurements of voltage and/or current in the distribution system. Among the previous studies, Hidden Markov Model (HMM) based models have been studied very much. However, increasing appliances, multistate of appliances, and similar power consumption of appliances are three big issues in NILM recently. In this paper, we address these problems through providing our contributions as follows. First, we proposed state-of-the-art energy disaggregation based on Long Short-Term Memory Recurrent Neural Network (LSTM-RNN) model and additional advanced deep learning. Second, we proposed a novel signature to improve classification performance of the proposed model in multistate appliance case. We applied the proposed model on two datasets such as UK-DALE and REDD. Via our experimental results, we have confirmed that our model outperforms the advanced model. Thus, we show that our combination between advanced deep learning and novel signature can be a robust solution to overcome NILM's issues and improve the performance of load identification.
Mitigation of Perfluorosulfonic Acid Membrane Chemical Degradation Using Cerium and Manganese Ions (2008)

Cerium and manganese ions are very effective reversible scavengers of •OH in an operating PFSA-based PEM fuel cell. The use of these ions in very small quantities can reduce the fluoride release rate by up to three orders of magnitude relative to an unmitigated sample and thereby afford extremely durable membranes. A chemically rational mechanism that accounts for the remarkable effectiveness of these chemical mitigants is presented.
Antineoplastic activity of poly(L-lysine) with some ascites tumor cells. (1979)

We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 x 10(3)) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells. White Swiss mice show nearly a 100% remission from subsequent tumor growth. Rechallenge of "cured" animals with tumor cells, however shows no long-term immunological protection. In tissue culture, poly(L-lysine) shows a related potent cytotoxicity with HeLa cells; interestingly, the D isomer. In addition, there is a strong molecular weight dependence in that the small polylysine (Mr 3 x 10(3)) possesses less than 1/20th the cytotoxicity of large polymers (Mr 70 x 10(3)) on a weight basis in both cell culture and animal studies. At the same time, none of these lysine polymers gives any significant increase in life span to BDF1 mice infected with L1210 murine leukemia cells. We have also further explored the mechanism by which the polylysines express their cytotoxicity. These data indicate that lysine polymers show cell specificity in their action and in some cases they may be beneficial as potent antineoplastic agents, particularly when molecular weight is taken into consideration.
Just-in-time personalized video presentations (2012)

Using high-quality video cameras on mobile devices, it is relatively easy to capture a significant volume of video content for community events such as local concerts or sporting events. A more difficult problem is selecting and sequencing individual media fragments that meet the personal interests of a viewer of such content. In this paper, we consider an infrastructure that supports the just-in-time delivery of personalized content. Based on user profiles and interests, tailored video mash-ups can be created at view-time and then further tailored to user interests via simple end-user interaction. Unlike other mash-up research, our system focuses on client-side compilation based on personal (rather than aggregate) interests. This paper concentrates on a discussion of language and infrastructure issues required to support just-in-time video composition and delivery. Using a high school concert as an example, we provide a set of requirements for dynamic content delivery. We then provide an architecture and infrastructure that meets these requirements. We conclude with a technical and user analysis of the just-in-time personalized video approach.
토양 유실량 및 유출수량 측정을 위한 회전분할집수기의 평가 (2008)

For the standard method of collecting the run-off, it is consumed the high cost and much effort to install and to manage this instrument. Because the all the soil and water from reservoir tank must be eliminate after their measurement of amount of soil loss and run-off and installed the reservoir tank at regular size in the experimental field. Therefore, objective of this study was to compare its efficacy between the standard method and a flow rotate divider for continuously collecting and measuring the soil loss and run-off in order to conveniently conduct the field experiment of the lysimeters. For collecting the sampling of soil loss and run-off from agricultural land with invariable ratio, a flow rotate divider was consisted with a 8 blades of round plate sloped in order to collect the invariable ratio of soil and water at lowest part from round plate by the law of gravity. For comparing its accuracy in the batch scale experiment, it shown that there was significantly a positive linear corelation (r=0.997***) between flowing and sampling amounts with adjusting the range from 1 to 10 L min-1 with flowing rate. In collecting ratio in the field experiment, it observed that the more its accuracy had, the more soil loss and run-off.
Beamformer designs for zero-forcing dirty paper coding (2011)

We consider the beamformer design for zero-forcing dirty paper coding (ZF-DPC), a suboptimal transmission technique for MISO broadcast channels (MISO BCs). For the sum rate maximization problem under a total power constraint, the existing beamformer designs in the literature are based on the QR decomposition (QRD), which is used to satisfy the ZF constraints. However, the optimality of the QRD-based design has been unknown previously. In this paper, we prove that the QRD-based design is optimal for ZF-DPC for any performance measure under a sum power constraint. For the per-antenna power constraints, the QRD-based designs become suboptimal, and we propose an optimal design, using a convex optimization framework. Low-complexity suboptimal designs are also presented, and numerically shown to achieve a significant fraction of the sum rate provided by the optimal design.
Synchromesh: Reliable code generation from pre-trained language models (2022)

Large pre-trained language models have been used to generate code,providing a flexible interface for synthesizing programs from natural language specifications. However, they often violate syntactic and semantic rules of their output language, limiting their practical usability. In this paper, we propose Synchromesh: a framework for substantially improving the reliability of pre-trained models for code generation. Synchromesh comprises two components. First, it retrieves few-shot examples from a training bank using Target Similarity Tuning (TST), a novel method for semantic example selection. TST learns to recognize utterances that describe similar target programs despite differences in surface natural language features. Then, Synchromesh feeds the examples to a pre-trained language model and samples programs using Constrained Semantic Decoding (CSD): a general framework for constraining the output to a set of valid programs in the target language. CSD leverages constraints on partial outputs to sample complete correct programs, and needs neither re-training nor fine-tuning of the language model. We evaluate our methods by synthesizing code from natural language descriptions using GPT-3 and Codex in three real-world languages: SQL queries, Vega-Lite visualizations and SMCalFlow programs. These domains showcase rich constraints that CSD is able to enforce, including syntax, scope, typing rules, and contextual logic. We observe substantial complementary gains from CSD and TST in prediction accuracy and in effectively preventing run-time errors.
Gestural Control of Sound Synthesis (2004)

This paper provides a review of gestural control of sound synthesis in the context of the design and evaluation of digital musical instruments. It discusses research in various areas related to this field and equally focuses on four main topics: analysis of music performers' gestures, gestural capture technologies, real-time sound synthesis methods, and strategies for mapping gesture variables to sound synthesis input parameters. Finally, this approach is illustrated by presenting an application of this research to the control of digital audio effects.
Molecular Characterization of Colorectal Neoplasia in Translational Research (2001)

Currently, the prognosis of patients with CRC is predicted primarily on the basis of clinicopathologic staging; however, pathologists and oncology surgeons have recently begun to investigate the use of molecular markers to diagnose and/or understand the progression of CRC. In recent years, much has been learned about the molecular events responsible for the development of CRC. Also, several studies have reported the implication of some molecular markers in metastasis and tumor aggression and their usefulness in predicting clinical outcome. In this article, we discuss the use of specific molecular markers, including tumor-associated glycoprotein 72 (TAG-72), carcinoembryonic antigen (CEA), and oncofetal tumor antigens (Lewis X and Y) in diagnosis and as targets for novel therapies, as well as the phenotypic expression of bcl-2, mucin antigens (MUC1 and MUC2), and nuclear accumulation of p53 in predicting the clinical outcome of patients with CRC. We also review the ways in which molecular markers may aid the early detection of colorectal neoplasia and promote our understanding of the earliest changes in colorectal neoplasia.
Minimal Role for the Circumsporozoite Protein in the Induction of Sterile Immunity by Vaccination with Live Rodent Malaria Sporozoites (2010)

Immunization with live Plasmodium sporozoites under chloroquine prophylaxis (Spz plus CQ) induces sterile immunity against sporozoite challenge in rodents and, more importantly, in humans. Full protection is obtained with substantially fewer parasites than with the classic immunization with radiation-attenuated sporozoites. The sterile protection observed comprised a massive reduction in the hepatic parasite load and an additional effect at the blood stage level. Differences in the immune responses induced by the two protocols occur but are as yet little characterized. We have previously demonstrated that in mice immunized with irradiated sporozoites, immune responses against the circumsporozoite protein (CSP), the major component of the sporozoite's surface and the leading malaria vaccine candidate, were not essential for sterile protection. Here, we have employed transgenic Plasmodium berghei parasites in which the endogenous CSP was replaced by that of Plasmodium yoelii, another rodent malaria species, to assess the role of CSP in the sterile protection induced by the Spz-plus-CQ protocol. The data demonstrated that this role was minor because sterile immunity was obtained irrespective of the origin of CSP expressed by the parasites in this model of protection. The immunity was obtained through a single transient exposure of the host to the immunizing parasites (preerythrocytic and erythrocytic), a dose much smaller than that required for immunization with radiation-attenuated sporozoites.
Face to virtual face (1998)

The first virtual humans appeared in the early 1980s in such films as Dreamflight (1982) and The Juggler (1982). Pioneering work in the ensuing period focused on realistic appearance in the simulation of virtual humans. In the 1990s, the emphasis has shifted to real-time animation and interaction in virtual worlds. Virtual humans have begun to inhabit virtual worlds and so have we. To prepare our place in the virtual world we first develop techniques for the automatic representation of a human face capable of being animated in real time using both video and audio input. The objective is for one's representative to look, talk, and behave like oneself in the virtual world. Furthermore, the virtual inhabitants of this world should be able to see our avatars and to react to what we say and to the emotions we convey. We sketch an overview of the problems related to the analysis and synthesis of face-to-virtual-face communication in a virtual world. We describe different components of our system for real-time interaction and communication between a cloned face representing a real person and an autonomous virtual face. It provides an insight into the various problems and gives particular solutions adopted in reconstructing a virtual clone capable of reproducing the shape and movements of the real person's face. It includes the analysis of the facial expression and speech of the cloned face, which can be used to elicit a response from the autonomous virtual human with both verbal and nonverbal facial movements synchronized with the audio voice.
Recombinant PDGF from Lower Vertebrates: Receptor Binding and Immunochemical Analysis with Metabolically Labeled Growth Factor (1992)

We used a baculovirus vector/insect host cell system to express cDNA clones of PDGF A genes from mouse and frog (Xenopus laevis). The insect host cells process PDGF A subunits from either frogs or mice into biologically active AA homodimers with yields in the range of 0.5-1.0 mg/liter of culture medium. The recombinant PDGFs can be metabolically labeled with 35S-cysteine for use in radioreceptor and radioimmunoassays. Neutralizing polyclonal antisera can be raised against the mouse and frog PDGFs. These antisera are markedly species-specific in action. However, in radioreceptor binding assays and bioassays for mitogenic activity, human, mouse and frog PDGF AA homodimers occupy and activate murine PDGF receptors with equal efficiency.
Enhancing Auditory Selective Attention Using a Visually Guided Hearing Aid (2017)

http://cred.pubs.asha.org/article.aspx?articleid=2601621.
Research and implementation of master-slave control for interventional robot system (2017)

Minimally invasive endovascular surgery is an important means of treatment of cardiovascular diseases. The operation of traditional surgical intervention operation system was very difficult. And it is a departure from the hand-held conduit progressive doctors operating mode. The doctors are asked too much for the intubation. In order to solve this problem, based on the new catheter mechanical means a linear stepper / push mechanism guide-wire with scaling control method between master and slave, a mobile surgical robot master-slave control system was designed, and the performance of this device was tested. Experiments showed that the axial movement between the master and slave system error is less than 1%, and the rotational movement accuracy is better than 1 degree in performance and functionality to meet the requirements of vascular interventional procedures.
Extracellular matrix protein 1 regulates cell proliferation and trastuzumab resistance through activation of epidermal growth factor signaling (2014)

ECM1 has important roles in both cancer development and trastuzumab resistance in breast cancer through activation of EGFR signaling.
Unsupervised content discovery in composite audio (2005)

Automatically extracting semantic content from audio streams can be helpful in many multimedia applications. Motivated by the known limitations of traditional supervised approaches to content extraction, which are hard to generalize and require suitable training data, we propose in this paper an unsupervised approach to discover and categorize semantic content in a composite audio stream. In our approach, we first employ spectral clustering to discover natural semantic sound clusters in the analyzed data stream (e.g. speech, music, noise, applause, speech mixed with music, etc.). These clusters are referred to as audio elements. Based on the obtained set of audio elements, the key audio elements, which are most prominent in characterizing the content of input audio data, are selected and used to detect potential boundaries of semantic audio segments denoted as auditory scenes. Finally, the auditory scenes are categorized in terms of the audio elements appearing therein. Categorization is inferred from the relations between audio elements and auditory scenes by using the information-theoretic co-clustering scheme. Evaluations of the proposed approach performed on 4 hours of diverse audio data indicate that promising results can be achieved, both regarding audio element discovery and auditory scene categorization.