gebhart/patrepeval huggingface dataset:
Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells (2017)

Biological scaffolds composed of tissue-derived extracellular matrix (ECM) can promote homologous (i.e., tissue-specific) cell differentiation through preservation of biophysical and biochemical motifs found in native tissues. Solubilized ECMs derived from decellularized tendon and cartilage have recently been promoted as tissue-specific biomaterials, but whether tissue-specific bioactivity is preserved following solubilization is unknown. This study explored the tissue-specific bioactivity of soluble decellularized tendon and cartilage ECMs on human bone marrow-derived mesenchymal stem cells (MSCs) presented across different culture microenvironments, including two-dimensional (2D) tissue culture plastic, aligned electrospun nanofibers, cell pellets, and cell-seeded photocrosslinkable hydrogels. Tendon and cartilage ECMs were decellularized using established methods and solubilized either via pepsin digestion or urea extraction. The effect of soluble ECMs on cell proliferation and differentiation was initially explored by supplementing basal medium of human MSCs cultured on 2D tissue culture plastic. In subsequent experiments, MSCs were cultured on aligned electrospun nanofibers, ascell pellets, or encapsulated within photocrosslinkable methacrylated gelatin (GelMA) hydrogels. Urea-extracted tendon and cartilage ECMs were added as supplements. Pepsin-digested ECMs did not promote homologous differentiation in human MSCs, whether provided as a medium supplement or three-dimensional (3D) hydrogels. In contrast, urea-extracted ECMs tended to promote tissue-specific differentiation of MSCs cultured in 2D and 3D microenvironments. The application of the small molecule TGF-β signaling inhibitor SB-431542 largely negated the tissue-specific gene expression patterns mediated by tendon and cartilage ECMs. This suggests that the action of endogenous TGF-β was required, but was not sufficient, to impart tissue-specific bioactivity of urea-extracted ECMs. When urea-extracted cartilage ECM was incorporated within a photocurable GelMA hydrogel it independently enhanced chondrogenesis in encapsulated MSCs, and showed additive prochondrogenesis upon TGF-β supplementation in the medium. Urea-extracted ECM fractions of decellularized tendon and cartilage are soluble supplements capable of enhancing tissue-specific differentiation of adult stem cells.
Carbanion halogenations with carbon tetrahalides. .alpha.-Halo esters (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbanion halogenations with carbon tetrahalides. .alpha.-Halo estersRichard T. Arnold and Srdanka T. KulenovicCite this: J. Org. Chem. 1978, 43, 19, 3687–3689Publication Date (Print):September 1, 1978Publication History Published online1 May 2002Published inissue 1 September 1978https://pubs.acs.org/doi/10.1021/jo00413a010https://doi.org/10.1021/jo00413a010research-articleACS PublicationsRequest reuse permissionsArticle Views758Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Photochemical reactions of pyrimidinethiones with alkenes (1987)

Photochemical addition reactions of pyrimidinethiones and related compounds with alkenes have been examined. Irradiation of pyrimidine-4(3H)-thiones (1a) in the presence of electron-poor alkenes gave the 4-mercaptoalkylated pyrimidines (5), whereas irradiation of (1a) in the presence of electron-rich alkenes gave 4-alkylthiopyrimidines (6). Irradiation of quinazoline-4(3H)-thiones (1c–e) and electron-poor alkenes gave 4-substituted quinazolines (9) and (10). This ready mode of carbon-carbon bond formation provides an efficient and novel method for alkylation of pyrimidine rings.
Secure and Efficient Code Encryption Scheme Based on Indexed Table (2011)

Software is completely exposed to an attacker after it is distributed because reverse engineering is widely known. To protect software, techniques against reverse engineering are necessary. A code encryption scheme is one of the techniques. A code encryption scheme encrypts the binary executable code. Key management is the most important part of the code encryption scheme. However, previous schemes had problems with key management. In an effort to solve these problems in this paper, we survey the previous code encryption schemes and then propose a new code encryption scheme based on an indexed table. Our scheme provides secure and efficient key management for code encryption.
CT longitudinal scan (1976)

CT longitudinal scanHaaga, JR, RJ Alfidi, WJ MacIntyre, TR Havrilla and TF MeaneyAudio Available | Share
Screening and selection of novel animal probiotics isolated from bovine chyme (2012)

Probiotics, gut-colonizing microorganisms capable of conferring a number of health benefits to their hosts, are highly desirable as animal feed supplements. Members of the Gram-positive genus Bacillus are often utilized as probiotics, since endospores formed by those bacteria render them highly resistant to environmental extremes and therefore capable of surviving gastrointestinal tract conditions. In this study, 84 distinct bacterial colonies were obtained from bovine chyme and 29 isolates were determined as Bacillus species. These isolates were principally screened for their antimicrobial activity against a group of two Gram-positive and four Gram-negative bacteria, including known human and animal pathogens such as Salmonella enterica, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. Seven strains displaying strong antimicrobial activity against the test cohort were further evaluated for other properties desirable from animal probiotics, including high spore-forming capacity and adhesiveness, resistance to pH extremes and ability to form biofilms. The isolates were found to resist simulated gastrointestinal conditions and most of the antibiotics tested. In addition, plasmid presence was checked and cytotoxicity tests were performed to evaluate the potential risks of antibiotic resistance transfer and unintended pathogenic effects on host, respectively. We propose that the bacterial isolates are suitable for use as animal probiotics.
Structure and Biochemical Function of a Prototypical Arabidopsis U-box Domain (2004)

U-box proteins, as well as other proteins involved in regulated protein degradation, are apparently over-represented in Arabidopsis compared with other model eukaryotes. The Arabidopsis protein AtPUB14 contains a typical U-box domain followed by an Armadillo repeat region, a domain organization that is frequently found in plant U-box proteins. In vitro ubiquitination assays demonstrated that AtPUB14 functions as an E3 ubiquitin ligase with specific E2 ubiquitin-conjugating enzymes. The structure of the AtPUB14 U-box domain was determined by NMR spectroscopy. It adopts the betabetaalphabeta fold of the Prp19p U-box and RING finger domains. In these proteins, conserved hydrophobic residues form a putative E2-binding cleft. By contrast, they contain no common polar E2 binding site motif. Two hydrophobic cores stabilize the AtPUB14 U-box fold, and hydrogen bonds and salt bridges interconnect the residues corresponding to zinc ion-coordinating residues in RING domains. Residues from a C-terminal alpha-helix interact with the core domain and contribute to stabilization. The Prp19p U-box lacks a corresponding C-terminal alpha-helix. Chemical shift analysis suggested that aromatic residues exposed at the N terminus and the C-terminal alpha-helix of the AtPUB14 U-box participate in dimerization. Thus, AtPUB14 may form a biologically relevant dimer. This is the first plant U-box structure to be determined, and it provides a model for studies of the many plant U-box proteins and their interactions. Structural insight into these interactions is important, because ubiquitin-dependent protein degradation is a prevalent regulatory mechanism in plants.
Cardiogel supports adhesion, proliferation and differentiation of stem cells with increased oxidative stress protection (2011)

Cultured murine bone marrow derived mesenchymal stem cells (BMSC) when grown along with cardiogel derived from mouse cardiac fibroblast, exhibited increased cell proliferation and differentiation and enhanced survival under oxidative stress induced by the exposure of H2O2 in vitro (similar to in vivo ischemia like condition). Adhesion of BMSC to the cardiogel occurred at a faster rate when compared to the cells grown on normal surface. BMSC attached to cardiogel showed an increased resistance to proteolytic (enzymatic) disassociation. This is the first report on an attempt to use an in house biomaterial for the growth of BMSC that led to their heightened resistance towards oxidative stress. These studies support that cardiogel is an efficient biodegradable three-dimensional extracellular matrix which supports better growth of BMSC and can be used as a scaffold for stem cell delivery, with potential therapeutic applications in cardiac tissue regeneration.
Distributed Virtual Environments: From client server to cloud and P2P architectures (2012)

Distributed Virtual Environments (DVEs), like Massively Multiplayer Online Games (MMOG) are attracting millions of users from all over the world. However, as the number of simultaneous users keeps growing, the current used Client/Server infrastructure technologies are showing their limits on the side of the practicality and applicability. As a consequence, novel solutions based on Cloud and P2P architectures have been recently proposed. While Cloud Architectures permit to overcome the over provisioning problem of C/S architectures, the advent of home xDSL connection capability permits to explore the capability of P2P approaches to design the infrastructure of next-generation DVEs. The use of P2P distributed infrastructures permits to exploit the inherent scalability of DVE, their robustness and self-organizing properties. However, this solution has to face with additional related challenges such as consistency, persistence and limited hardware capabilities of the peers. This paper discusses the main research challenges and reviews the main DVE architectures proposed in the last years.
Elimination reactions of stilbene dibromides. Dehydrobromination by acetate, cyanide or chloride ions in dimethylformamide (1983)

Rates of dehydrobromination of a series of 4-nitro-and methoxystilbene dibromides by means of acetate, cyanide or chloride ions in dimethylformamide have been measured. A product analysis was performed which indicated a strong preference for anti elimination. Probable transition state structures utilized by each of the three nucleophiles are described. Attack by the base may be at either ß-hydrogen (E2H) or Ca (E2C). The slowest reaction is with chloride ion, which also gives the highest anti/syn elimination product ratio.
Study of recessed MR sensors with unlaminated and multi-laminated flux-guides (1992)

The authors have fabricated unshielded and shielded magnetoresistive (MR) sensors with various flux-guide configurations and studied their behavior using MR response and Kerr effect techniques. Results show interesting effects involving interactions of the MR sensor with the flux-guides and with the shielding environment, ranging from transverse bias enhancement effects of shields and flux-guides to the excitation of multidomain states in unshielded MR sensors by strong signal flux from the long back flux-guides. The multilaminated flux-guides are shown to be much better in noise behavior compared to the unlaminated flux-guides, although small amounts of jumps are still present, as expected from edge-curling wall magnetics. The presence of a long back flux-guide enhances the read sensitivity distinctly, but might also render flux-guide noise problems more critical in the operation of the sensor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Fabrication of FePt type exchange coupled composite bit patterned media by block copolymer lithography (2011)

We fabricated exchange coupled composite (ECC) L10 ordered, (001) oriented FePt (5nm)/Fe (5 nm) bit patterned media over a large area by diblock copolymer lithography. We formed the dot arrays of the copolymer directly on the magnetic film and used them as the etching mask. The average size of the ECC FePt/Fe pillars was about 32 nm, with a center to center distance of about 35 nm and a size distribution of about 8%. The perpendicular coercivity (Hc) of the ECC FePt/Fe patterned structures was about 4.3 kOe. Both the coercivity and the saturation field of the ECC FePt/Fe patterned structure were reduced by about 50% due to the exchange coupling between FePt and Fe in the FePt/Fe patterned structure compared to the FePt patterned structure with similar dot size and distribution. The thermal stability and gain factor of the FePt/Fe ECC structure were about 260 kBT and 1.35, respectively.
Reframing hostility (2002)

This paper comments on the Annette Hemmings's paper entitled, 'Youth culture of hostility: Discourses of money, respect and difference.' The paper briefly looks at Hemmings's findings, in particular those related to identity development. However, the major focus is on reframing methodological aspects of Hemmings's study. In particular, the paper examines challenges facing cultural outsiders doing research; the dynamic and multiple roles of the researcher in discourse analysis (i.e., participant, observer, and subject); and a theoretical rationale for including the researcher as subject in research, which is based on Foucault's notion of how discourse systems impact the construction of people's sense of social, political and cultural realities.
Polysaccharide Antigens of<i>Pseudomonas Aeruginosa</i> (1990)

The major polysaccharide antigens of P. aeruginosa are the cell-wall lipopolysaccharides many of which have an acidic polysaccharide chain (O-antigen) rich in unusual amino sugars. The D-rhamnose-rich polysaccharide antigen common to many serologically distinct strains is also associated with the lipopolysaccharide. The high-molecular-weight polysaccharides with O-specificity are present in extracellular slime produced by strains isolated from the environmental and from the immunocompromised hosts. The extracellular antigenic polysaccharide of another type (bacterial alginate) is expressed by mucoid strains isolated from patients with cystic fibrosis. Serotype-specific immune responses after infection are directed at the lipopolysaccharides and these heat-stable antigens serve as the basis for differentiation of P. aeruginosa strains. Both the cell-wall antigens including conjugates of the O-polysaccharides with different proteins and the extracellular antigens have been used to prepare specific antibodies tested for protection against infections due to P. aeruginosa.
Stability Diagram of a Few-Electron Triple Dot (2006)

Individual and coupled quantum dots containing one or two electrons have been realized and are regarded as components for future quantum information circuits. In this Letter we map out experimentally the stability diagram of the few-electron triple dot system, the electron configuration map as a function of the external tuning parameters, and reveal experimentally for the first time the existence of quadruple points, a signature of the three dots being in resonance. In the vicinity of these quadruple points we observe a duplication of charge transfer transitions related to charge and spin reconfigurations triggered by changes in the total electron occupation number. The experimental results are largely reproduced by equivalent circuit analysis and Hubbard models. Our results are relevant for future quantum mechanical engineering applications within both quantum information and quantum cellular automata architectures.
Carboxylate−Imidazole Cooperativity in Dipeptide-Functionalized Gold Nanoparticles with Esterase-like Activity (2005)

We report here the first example of peptide-functionalized gold nanoparticles hydrolytically active against carboxylate esters. The active units are constituted by His-Phe-OH terminating thiols. The confinement of the catalytic units in the monolayer covering the nanoparticles triggers a cooperative hydrolytic mechanism operative at pH < 7 in which a carboxylate and an imidazolium ion act as general base and general acid, respectively. Such a mechanism is absent with an analogous monomeric dipeptide, and this results in a more than 300-fold rate acceleration of the hydrolytic process at low pH in the presence of the functional nanoparticles.
Meta-analysis of colorectal cancer follow-up after potentially curative resection (2016)

Based on pooled data from randomized trials published from 1995 to 2016, the anticipated survival benefit from surgical treatment resulting from earlier detection of metastases has not been achieved.
Searching the Diaspora (1992)

Essay| April 01 1992 Searching the Diaspora: An Interview with John Akomfrah Thomas Allen Harris Thomas Allen Harris Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1992) 19 (9): 10–13. https://doi.org/10.1525/aft.1992.19.9.10 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Thomas Allen Harris; Searching the Diaspora: An Interview with John Akomfrah. Afterimage 1 April 1992; 19 (9): 10–13. doi: https://doi.org/10.1525/aft.1992.19.9.10 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAfterimage Search This content is only available via PDF. © 1992 by The Regents of the University of California1992 Article PDF first page preview Close Modal You do not currently have access to this content.
Laser diode end-pumped efficient coupling system based on microlens arrays (2009)

Efficient pumped coupling is one of the important technologies of diode pumped solid state laser system applying end-pumped structure. This work present a novel pumped coupling optical system based on microlens arrays. In the coupling system, the light of laser diode stack is incident on an imaging microlens array, that cuts the beam into a number of beamlets. Subsequently these beamlets are overlapped in the pumped surface of laser media through an aspheric focusing lens. Then a high homogeneity pump field is realized. Furthermore, for different aspect ratios of the homogenized spot two microlens arrays with crossed cylindrical lenses are used to match different pump field size. Such coupling system was designed by ray tracing method using ZEMAX<sup>TM</sup> Non-Sequential Components analysis tools. The non-sequential raytracing simulation shows that a 5 × 5 mm<sup>2</sup> Top-Hat intensity pump profile was got at a working distance of 40 mm and the homogeneity of the intensity distribution is better than 90%. In comparison with the traditional coupling optical system homogenization by means of microlens arrays is more flexible and requires a reduced number of optical components.
Anti-cytokine antibodies for rheumatic diseases. (2009)

Improved knowledge regarding the pathogenetic mechanisms involved in autoimmune diseases has contributed to the development of biological therapies, with advances in cytokine research in particular revolutionizing the treatment of several autoimmune diseases. Anti-TNF agents are the most promising drugs for reducing symptoms, slowing or arresting joint damage, and preventing functional disability in patients with rheumatoid arthritis who fail to respond to standard disease-modifying antirheumatic drugs. Anti-TNF agents may also be useful in the treatment of other rare disorders, such as various forms of vasculitis, polymyositis and dermatomyositis. However, clinical trials of TNF inhibitors and inhibitors of the proinflammatory cytokines IL-1, IL-6, IL-12, IL-15, IL-17 and IL-23 demonstrated that the activity of such compounds is accompanied by a series of adverse events that needs to be addressed. This review describes the efficacy and adverse events associated with anti-cytokine treatments for autoimmune rheumatic diseases.
Case 39-1987 (1987)

Presentation of CaseA 90-year-old woman was admitted to the hospital because of diarrhea, nausea, and vomiting.She was in a static state of health until several weeks earlier, when intermittent diarrhea developed. Ten days before admission the diarrhea became nearly constant, and the patient vomited small amounts of bile-stained fluid. Her physician found that peristaltic sounds were diminished; there was no distention, tenderness, or mass. Rectal examination disclosed a soft fecal impaction. A glycerin suppository was administered with satisfactory results, and the patient attended her 90th birthday party five days before entry. Three days later she again vomited and . . .
Thermal lens spectrometry to study complex fluids (1998)

We describe applications of Thermal Lens Spectrometry to study optical and thermal properties of lyotropic liquid crystal. In particular, we refer to methods for measurements of thermal diffusivity anisotropy at different temperatures and as a function of the ferrofluids doping. The theoretical basis for quantitative measurements is discussed together with the advantages and limitations as compared with conventional methods. Finally, future developments of photothermal techniques for these applications are assessed.
Comparison of structural behavior of superplastically formed/diffusion-bonded sandwich structures and honeycomb core sandwich structures (1980)

A superplasticity formed/diffusion-bonded (SPF/DB) orthogonally corrugated core sandwich structure is discussed and its structural behavior is compared to that of a conventional honeycomb core sandwich structure. The stiffness and buckling characteristics of the two types of sandwich structures are compared under conditions of equal structural density. It is shown that under certain conditions, the SPF/DB orthogonally corrugated core sandwich structure is slightly more efficient than the optimum honeycomb core (square-cell core) sandwich structure. However, under different conditions, this effect can be reversed.