gebhart/patrepeval huggingface dataset:
A dominant negative G alpha s mutant is rescued by secondary mutation of the alpha chain amino terminus. (1991)

The Gs protein alpha subunit, alpha s, stimulates the activity of adenylyl cyclase. The sequence 223Asp-Val-Gly-Gly-Gln227 in the alpha s polypeptide is predicted to interact with the gamma-phosphate of GTP and mediate the conformational change involved in alpha s activation. Mutation of the alpha s polypeptide within this region at Gly225----Thr had two demonstrative phenotypic effects when expressed in COS-1 cells: the mutant alpha s chain was ineffective in activating adenylyl cyclase and inhibited in a concentration-dependent manner the beta-adrenergic receptor stimulation of cAMP synthesis. Thus, the Gly225----Thr mutation alters the ability of GTP to activate the alpha s chain and when overexpressed the mutant polypeptide exerts a dominant negative phenotype. Mutation at the amino terminus which creates a constitutively active alpha s rescued the inhibited state of the Gly225----Thr mutant when both mutations were encoded in the same polypeptide. This finding defines the amino terminus as a functional regulatory domain controlling the properties of the GTP/GDP binding site of G protein alpha subunit polypeptide chains.
TRPA1 channel activation induces cholecystokinin release via extracellular calcium (2007)

TRPA1 channels are non-selective cation channels activated by plant derived pungent products including allyl isothiocyanate (AITC) from mustard. Therefore, possible intestinal secretory functions of these channels were investigated. We detected TRPA1 mRNA in mouse and human duodenal mucosa and in intestinal mouse neuroendocrine STC-1 cells. Stimulation of STC-1 cells with AITC increased intracellular calcium ([Ca(2+)](i)) and significantly stimulated cholecystokinin secretion by 6.7-fold. AITC induced cholecystokinin release was completely blocked by TRPA1 antagonist ruthenium red and depletion of extracellular calcium and reduced by 36% by nimodipine and nifedipine. This suggests that spices in our daily food might stimulate digestive functions.
The virtual Set-Top Box: On the shift of IPTV service execution, service &amp; UI composition into the cloud (2013)

This paper introduces the concept of the so-called virtual Set-Top Box (vSTB). The idea of the vSTB represents a novel and fundamental change in the creation and delivery of media services as IP Television (IPTV), by shifting most of the service execution environment - e.g. the Web browser - to a Cloud infrastructure. This paper describes the overall approach of this idea, addresses and identifies the technical challenges, which emerged in a corresponding project in the Telekom Innovation Laboratories, and provides a wide theoretical basis for further research on Cloud service execution environments.
Transparency and reflection in distributed systems (1993)

The recursive composition of systems to form functionally equivalent transparently distributed systems is an important paradigm for constructing distributed systems. The extent to which such recursive transparency can be achieved depends crucially on the semantics and functionality offered by the underlying systems. It is therefore important that systems should be designed so that their functionality scales gracefully in a distributed environment.In order to build a transparent extension to a system, it is necessary to be able to intercept its basic operations and extend their meaning to a distributed environment. This requires the underlying system to have a clean structure with well-defined interfaces and the reflective capability necessary to intercept and extend operations crossing those interfaces. Thus, both reflection and transparency are important aspects of the design of extensible distributed systems.It is possible to make transparent extensions to object-oriented systems built on top of micro-kernel architectures but the lack of reflective capabilities in the current generation of object-oriented programming languages can make this unnecessarily awkward. More research is required to develop languages whose computational model and implementation are a better match for the underlying platforms which support them.
Applying machine learning to stock market trading (2018)

With the development of the artificial intelligence, the application of machine learning in finance field has attracted extensive attention from investors and researchers. This article combines stock selection, stock data pre-processing, neural network LSTM improved model to predict stocks. We first used three companies' financial indicators (Cash flow per share/earnings per share; Return on net assets; Sales gross margins) to analyze the 3,000 stocks in Shanghai. Results showed that with the minimum clustering principle, choose a stock is more valuable to the investment. Next, we used the quantitative trading platform to collect six indicators of stock data: the opening price, the closing price, the highest price, the lowest price, volume and turnover. Then six feature data were preprocessed using wavelet denoising. We further used the modified three-layer LSTM model to predict the closing price of the transaction with denoising data. This article analyzes\n the influence of the scale of the training data on the prediction results and finds that the de-noise processing has a better prediction effect in the small-scale data model. Meanwhile, the prediction result is better when the learning rate is 0.004. Overall, the LSTM neural network has a better prediction result with denoise shortterm\n data than the original long-term data.
Application of “omics” to Prion Biomarker Discovery (2010)

The advent of genomics and proteomics has been a catalyst for the discovery of biomarkers able to discriminate biological processes such as the pathogenesis of complex diseases. Prompt detection of prion diseases is particularly desirable given their transmissibility, which is responsible for a number of human health risks stemming from exogenous sources of prion protein. Diagnosis relies on the ability to detect the biomarker PrP(Sc), a pathological isoform of the host protein PrP(C), which is an essential component of the infectious prion. Immunochemical detection of PrP(Sc) is specific and sensitive enough for antemortem testing of brain tissue, however, this is not the case in accessible biological fluids or for the detection of recently identified novel prions with unique biochemical properties. A complementary approach to the detection of PrP(Sc) itself is to identify alternative, "surrogate" gene or protein biomarkers indicative of disease. Biomarkers are also useful to track the progress of disease, especially important in the assessment of therapies, or to identify individuals "at risk". In this review we provide perspective on current progress and pitfalls in the use of "omics" technologies to screen body fluids and tissues for biomarker discovery in prion diseases.
Effect of Orally Administered Glutathione Peroxidase Mimetic towards Glutathione and Malondialdehyde Blood Level and Otoacoustic Emissions Result in Soldiers with Acoustic Trauma Risk Caused by Howitzer 105 Artillery Weapon BLAST (2019)

Excessive noise exposure may cause mechanical and metabolic (oxidative stress) to the inner ear structure (cochlea), resulting in acoustic trauma (TA). Oxidative stress which caused by increasing of free radical ROS/RNS in the organs of Corti, causing apoptosis and necrosis of cochlear hair cell. Oxidative stress was characterized by increasing of malondialdehyde (MDA), decreasing of glutathione peroxidase (GPx) enzyme, and abnormal otoacoustic emission value (refer). Defense mechanism toward oxidative stress was mediated by endogenous antioxidant enyzme (superoxide dismutase/SOD, catalase/CAT, and GPx). Cellular mechanism of glutation peroxidase mimetic was similar as GPx.Â Â Â Â Aim of this study was to determine the impact of glutathione peroxidase mimetic to glutathione peroxidase and malondialdehyde level in blood, also otoacoustic emission value on soldiers with risk of TA due to explosion of Howitzer 105 artillery weapon. The design of this study was clinical trial pre and post design, randomized, double blind and placebo controlled, on 34 new recruit soldiers in Artillery Academy of Indonesian Army, during the soldiers were trained to firing Howitzer 105 artillery weapon, from 7th-10th July 2014 in Cimahi and Batujajar. Subjects were divided into 2 groups, the exposure group (group given treatment) and control group. Exposure group was given glutathione peroxidase mimetic (Ebselen SPI 1005) 200mg, orally once daily during the training, meanwhile control group was given. Malondialdehyde and Glutathione Peroxidase level in blood, pure tone audiometry and otoacoustic emission value (DPOAEs) was measured from those two groups, before and after firing training. The data was analyzed using parametric and non parametric, with Number Needed to Treat (NNT, 95%CI) and significance value (p<0.05).Â Â Â Â The results of this study showed the number of acoustic trauma events in controle group based on pure tone audiometry test was 23.5%, exposure group was 0%, and based on DPOAEs test the controle group showed 47.1% abnormal/refer, exposure group showed 100% normally/pass, and this difference stastically significance (p<0.051). The group which was given Ebselen SPI 1005 showed increasing 82.4% erythrocyte GPx level (NNT, 95%CI=1.889 [1.159-3.016]; p=0.004), showed increasing 88.2% plasma GPx level (NNT, 95%CI=1.417 [0.970-1.775]; p<0.001), decreasing 100% erythrocyte MDA level (NNT, 95%CI = 2.125 [1.335-3.987]; p=0.01), Â showed decreasing 94.1% plasma MDA level (NNT, 95%CI=2.125 [1.29-3.904]; p=0.01), and resulting 100% in normal/pass DPOAEs value (NNT, 95%CI = 2.125 [1.335-3.987]; p=0.01). This study concluded that giving Ebselen SPI 1005 to soldiers with risk of acoustic trauma during the firing Howitzer 105 artillery weapon, increasing GPx level in blood, decreasing MDA level in blood, and resulting normally DPOAEs value (pass)
Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under<i>in vitro</i>conditions (2004)

Platelet-rich plasma is currently promoted to serve as an adjuvant for bone grafts to enhance quantity and quality of newly forming bone; however, the underlying cellular mechanisms are not fully understood. We show here that supernatants of leukocyte-depleted thrombin-activated platelets increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions. Using neutralizing antibodies raised against platelet-derived growth factor (PDGF), the observed effects of platelet-released supernatants were diminished. The mitogenic response was also decreased when extracellular signal-regulated protein kinase (ERK) signalling was inhibited by PD98059; however, PD98059 did not reverse the effects of platelet-released supernatants on migration and osteogenic differentiation. Consistent with an ERK-mediated mitogenic activity, incubation of serum-starved mesenchymal cell progenitors with platelet-released supernatants increased phosphorylation of the kinase. Together, these observations indicate that PDGF is a key factor released upon platelet activation that can increase migration and proliferation, and decreases osteogenic differentiation of mesenchymal progenitor cells under in vitro conditions. The results further suggest that ERK signalling is required to mediate the mitogenic response to platelet-released supernatants.
A High-Pressure Apparatus for TOF Neutron Diffraction (1980)

An alternative solution for a portable, smalldimensional helium (or hydrogen) gas apparatus is described. which allows a high hydrostatic pressure of up to 600 MPa to be maintained at low temperatures. Some recent results concerning the application of resistance-pressure gauges at lower temperatures are presented as examples for the reliability and usefulness of the device.
Decoupling of the short‐term hemodynamic response and the blood oxygen concentration (2001)

Neuronal activation leads to an increase in the local cortical perfusion. The exact regulatory mechanisms leading to these changes are still unknown. To elucidate the role of oxygen in the initial hemodynamic regulation, a disactivation paradigm was performed with fMRI. A stimulus was applied following a previous extended activation in order to evoke physiological variations of the local oxygen concentration. The results demonstrate that the initial hemodynamic response time is independent of the local blood oxygen concentration.
Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth (2011)

This study demonstrates that the vault nanocapsule can efficiently deliver CCL21 to sustain antitumor activity and inhibit lung cancer growth. The vault nanocapsule can serve as an "off the shelf" approach to deliver antitumor cytokines to treat a broad range of malignancies.
The DESIGN OF A HYDROELECTRIC POWER PLANT IS KIND OF A PELTON TURBINE ON A LABORATORY SCALE AS A LEARNING MEDIA (2023)

The power plant type turbine pelton of scale laboratory was made to be used as a practical medium of students and lecturers of mechanical engineering in the environment Politeknik of Kotabaru. The purpose of this research was to obtain an ideal design for hydropower systems as learning media; Knowing the effect of the lamp load on the generator rotation, knowing the effect of the type of 12 VDC and 24 VDC lamp loads with varying loads on the generator power output. The method used in this study is a literature study and experimental methods. The research results obtained are the design has a table height of 90 cm and a width of 100 cm, the height of the loading panel is 80 cm, the air pressure from the pump is 270 psi with a nozzle size of 1,7 mm, a 12 blade Pelton turbine, a 36 V 60 A DC generator; the type of lamp load affects of generator rotation where when the type of load is 12 VDC the generator rotation is smaller than when the lamp load is 24 VDC, while the large lamp load given to the system causes of generator rotation to decrease or the effect of the lamp load on generator rotation is inversely proportional; the greater of lamp load lower the output power of generator, both with 12 VDC and 24 VDC load types or in other words, it is also reversed.
Affinity labeling of neuronal acetylcholine receptor subunits with an alpha-neurotoxin that blocks receptor function. (1987)

An alpha-neurotoxin, Bgt 3.1, has previously been shown to recognize the functional acetylcholine receptor (AChR) on chick autonomic neurons, since it specifically blocks receptor function and it binds to a class of sites on the neurons with the pharmacology, kinetics, and affinity expected for the receptor. A monoclonal antibody, mAb 35, to the main immunogenic region of muscle and electric organ AChR alpha subunit cross-reacts with a component on chick autonomic neurons that, from several lines of evidence, also appears to be the functional AChR. The identity of the antibody-binding component has remained in doubt, however, because previous studies indicated that in at least one instance a substantial discrepancy existed between the number of functional AChRs estimated physiologically and the number of putative AChRs detected by mAb 35 on the neurons. The present findings demonstrate that Bgt 3.1 and mAb 35 recognize the same AChRs on the neurons, and provide information about the stoichiometry of binding and the identity of subunits associated with active sites on the receptor. Chick ciliary ganglion neurons examined under a variety of growth and regulatory conditions in culture displayed a constant ratio of about 2:1 for mAb 35 and Bgt 3.1 binding to cell surface sites. Treatment of the cells with mAb 35 induced a substantial decrease in the number of Bgt 3.1 sites and vice versa. AChRs that had been covalently labeled with a photoaffinity derivative of 125I-Bgt 3.1 in situ and then solubilized were specifically immune-precipitated by mAb 35, demonstrating unequivocally that the receptors possessed both Bgt 3.1 and mAb 35 binding sites.(ABSTRACT TRUNCATED AT 250 WORDS)
Does dose rate affect efficacy? The outcomes of 256 Gamma Knife surgery procedures for trigeminal neuralgia and other types of facial pain as they relate to the half-life of cobalt (2006)

Patients with facial pain appear to receive consistent treatment with GKS at any time during the first half-life of the Co sources.
건축종합설계에의 적용을 위한 디자인씽킹 기반 교육 프로그램 제안 (2017)

본 연구는 건축종합설계에의 적용을 위한 디자인씽킹 기반 교육 프로그램을 제안하는 것을 목표로 한다. 스탠포드 대학 d.school의 디자인씽킹 프로세스레 기반하여 교육 프로그램이 개발되었다. 제안된 교육 프로그램의 효과를 분석하기 위하여, 건축종합설계 교과목에 적용하고, 수강생들을 대상으로 설문을 수행하였다. 설문 결과, 디자인씽킹 기반 교육 프로그램이 기존의 교육 프로그램보다 만족도와 학습성과가 높았던 것으로 분석되었다.
High-bandwidth and high-thermal-stability graded-index polymer optical fiber (1998)

Recent progress of the graded-index polymer optical fiber (GI POF) is reviewed. Because the low attenuation of light transmission in the perfluorinated (PF) polymer base GI POF enables 500 to 1000 m transmission, more accurate analysis is required in the refractive index profile to realize the order of giga bit transmission. The analytical procedure of the bandwidth characteristics of the GI POF is described in this paper. Furthermore, recent improvement of the thermal stability of the GI POF is introduced. We clarified that the stability of the refractive index profile and the attenuation under high temperature and high humidity atmosphere can be improved by selecting the suitable dopant material.
Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats (2003)

The accumulation of intracellular triacylglycerol (TG) is highly correlated with muscle insulin resistance. However, it is controversial whether the accumulation of TG is the result of increased fatty acid supply, decreased fatty acid oxidation, or both. Because abnormal fatty acid metabolism is a key contributor to the pathogenesis of diabetes-related cardiovascular dysfunction, we examined fatty acid and glucose metabolism in hearts of insulin-resistant JCR:LA-cp rats. Isolated working hearts from insulin-resistant rats had glycolytic rates that were reduced to 50% of lean control levels (P < 0.05). Cardiac TG content was increased by 50% (P < 0.05) in the insulin-resistant rats, but palmitate oxidation rates remained similar between the insulin-resistant and lean control rats. However, plasma fatty acids and TG levels, as well as cardiac fatty acid-binding protein (FABP) expression, were significantly increased in the insulin-resistant rats. AMP-activated protein kinase (AMPK) plays a major role in the regulation of cardiac fatty acid and glucose metabolism. When activated, AMPK increases fatty acid oxidation by inhibiting acetyl-CoA carboxylase (ACC) and reducing malonyl-CoA levels, and it decreases TG content by inhibiting glycerol-3-phosphate acyltransferase (GPAT), the rate-limiting step in TG synthesis. The activation of AMPK also stimulates cardiac glucose uptake and glycolysis. We thus investigated whether a decrease in AMPK activity was responsible for the reduced cardiac glycolysis and increased TG content in the insulin-resistant rats. However, we found no significant difference in AMPK activity. We also found no significant difference in various established downstream targets of AMPK: ACC activity, malonyl-CoA levels, carnitine palmitoyltransferase I activity, or GPAT activity. We conclude that hearts from insulin-resistant JCR:LA-cp rats accumulate substantial TG as a result of increased fatty acid supply rather than from reduced fatty acid oxidation. Furthermore, the accumulation of cardiac TG is associated with a reduction in insulin-stimulated glucose metabolism.
Attributions and Stereotype Moderation (2007)

Two experiments were conducted to investigate the relationship between attributions made for stereotype-relevant behaviours and stereotype-based beliefs. In Experiment 1 participants were presented with a scenario describing an individual from a target group performing a stereotype consistent behaviour. After reading the scenario, participants completed attributional ratings for the behaviour and rated the target group on stereotype-relevant characteristics. In Experiment 2, participants read a scenario that described an individual performing either a stereotype-consistent or a stereotype-inconsistent behaviour. After reading the scenario, participants completed a sentence stem, which was subsequently coded for the presence of situational or dispositional attributions for the target behaviour. Participants also rated the target group on stereotype-based dimensions. In both experiments participants who made atypical attributions for the target behaviours (situational attributions for stereotype-consistent and dispositional attributions for -inconsistent behaviours) made less stereotype-based judgments of the target group than participants who made typical attributions (dispositional attributions for stereotype-consistent and situational attributions for -inconsistent behaviours). Results are discussed in terms of moderation of stereotypes.
Wideband external pulse recording during cuff deflation: a new technique for evaluation of the arterial pressure pulse and measurement of blood pressure. (1988)

Analysis of the external brachial pulse recorded during standard blood pressure cuff deflation with use of a transducer with a wide frequency response has revealed a reproducible pattern with three distinct components that we have labeled K1, K2, and K3. K1 is a low-amplitude, low-frequency signal that is present with cuff pressures above systolic pressure. K2 is a triphasic signal appearing at systolic pressure and disappearing at diastolic pressure, which approximately corresponds to the audible Korotkoff sound. K3 appears with cuff pressure between systolic and diastolic pressure and continues to be present below diastolic pressure. Intra-arterial pressure recordings made with a high-fidelity Millar catheter-tip manometer revealed K2 and K3 analogs. K3 resembles the intra-arterial pressure waveform and when calibrated according to the pulse pressure, noninvasive dK3/dt determinations correlated well with intra-arterial dP/dt measurements. The appearance/disappearance property of K2 was designated as the "K2 algorithm" and represents a new, objective noninvasive method for measurement of blood pressure. The K2 algorithm compares favorably with intra-arterial measurements, is more accurate than the auscultatory technique, and may be especially useful in clinical situations in which the auscultatory technique does not work well.
Periodic Prompts and Reminders in Health Promotion and Health Behavior Interventions: Systematic Review (2009)

In light of promising results of most studies, additional research on limited contact interventions targeting health behaviors including weight loss, physical activity, and/or diet is merited that utilizes rigorous methods including control groups; follow-up data collection; and testing of prompt frequencies, specific intervention components, or prompt characteristics. Future research would be especially valuable if it improves understanding of the most effective types of periodic prompts for fostering long-term behavior change in order to maximize use of this tool in limited contact health promotion programs. Specifically, various types of communication technology should be used and evaluated to expand and refine their use.
연구논문 : 한국 커피시장 현황과 21 세기의 비전 (1999)

The main propse of this study was to present condition of the Coffee and Vision of 21C in Korea. To achieve the propose of this study, Theoretical and empirical approaches were used. In review of theoretical background, basic concepts and characteristics of Coffee. Based on the theoretical studies and previous studies, vision of 21C in Korea. First, we`ll have to a national enterprise of coffee. Second, Instant coffee was export to china and east asia in 21C. Third, our Coffee culture was diversity, so wording is more easy. Fourth, coffee meeting will prosper