gebhart/patrepeval huggingface dataset:
A Novel Approach for the Detection and Genetic Analysis of Live Melanoma Circulating Tumor Cells (2015)

To our knowledge, this is the first report of a telomerase-based assay effective for detecting and isolating live melanoma CTCs. These promising findings support further studies, including towards integrating into the management of patients with melanoma receiving multimodality therapy.
Infectivity Selective Adenovirus Based on High-throughput Adenoviral Ligand Library Screening (2016)

An ultimate goal of the developers of cancer genetherapy/virotherapy is to develop a device enabling systemic treatment of the patients with advanced or spread diseases. The targeting at the level of infection, which can define the initial distribution following intravenous administration, is considered to be the most important for realization of systemic therapy. Adenovirus which has very high in vivo transduction efficiency is an attractive vector for designing novel cancer therapeutics for systemic therapy, and we and others have been working on this issue in the field of oncolytic adenovirus (OAd). However, the success rate of incorporation of targeting ligand to OAd without losing potency has been extremely low. We thus decided to run a screening of the ligand sequence in the adenoviral capsid format, and chose to replace 7 amino acids sequence mediating the initial binding of the virus to the receptor of adenovirus. By modifications and optimization of the production procedure, we achieved >1010 diversity, which permits the full coverage of 7 random amino acid library. Our high-throughput screening system is powerful enough to enable the screen of the adenovirusformat high-diversity library, and identified the specific targeting ligand in a highly efficient manner. In in vivo models, Infectivity Selective OAd (ISOAd) showed strong and selective anti-tumor effect in the xenotrafts of MSLN-positive pancreatic cancer cell line. The intravenously injected ISOAd targeting mesothelin showed a surprisingly strong antitumor effect, which was equivalent or stronger than that of intratumoral injection. These data indicate the possibility of systemic clinical application with ISOAd. While OAd is a very promising direction, the application of this novel series of vectors is not limited to OAd. Our screening strategy also produces many targeting ligands for therapeutic vector development. Our novel ligand identification system has broad implications to various purposes, and further development is anticipated. Keywords: Adenovirus, high-throughput screening, library, ligand, systemic therapy.
Long-term Blood Pressure Prediction with Deep Recurrent Neural Networks (2017)

Existing methods for arterial blood pressure (BP) estimation directly map the input physiological signals to output BP values without explicitly modeling the underlying temporal dependencies in BP dynamics. As a result, these models suffer from accuracy decay over a long time and thus require frequent calibration. In this work, we address this issue by formulating BP estimation as a sequence prediction problem in which both the input and target are temporal sequences. We propose a novel deep recurrent neural network (RNN) consisting of multilayered Long Short-Term Memory (LSTM) networks, which are incorporated with (1) a bidirectional structure to access larger-scale context information of input sequence, and (2) residual connections to allow gradients in deep RNN to propagate more effectively. The proposed deep RNN model was tested on a static BP dataset, and it achieved root mean square error (RMSE) of 3.90 and 2.66 mmHg for systolic BP (SBP) and diastolic BP (DBP) prediction respectively, surpassing the accuracy of traditional BP prediction models. On a multi-day BP dataset, the deep RNN achieved RMSE of 3.84, 5.25, 5.80 and 5.81 mmHg for the 1st day, 2nd day, 4th day and 6th month after the 1st day SBP prediction, and 1.80, 4.78, 5.0, 5.21 mmHg for corresponding DBP prediction, respectively, which outperforms all previous models with notable improvement. The experimental results suggest that modeling the temporal dependencies in BP dynamics significantly improves the long-term BP prediction accuracy.
PASTA (2018)

Token-based authentication is commonly used to enable a single-sign-on experience on the web, in mobile applications and on enterprise networks using a wide range of open standards and network authentication protocols: clients sign on to an identity provider using their username/password to obtain a cryptographic token generated with a master secret key, and store the token for future accesses to various services and applications. The authentication server(s) are single point of failures that if breached, enable attackers to forge arbitrary tokens or mount offline dictionary attacks to recover client credentials. Our work is the first to introduce and formalize the notion of password-based threshold token-based authentication which distributes the role of an identity provider among n servers. Any t servers can collectively verify passwords and generate tokens, while no t-1 servers can forge a valid token or mount offline dictionary attacks. We then introduce PASTA, a general framework that can be instantiated using any threshold token generation scheme, wherein clients can "sign-on" using a two-round (optimal) protocol that meets our strong notions of unforgeability and password-safety. We instantiate and implement our framework in C++ using two threshold message authentication codes (MAC) and two threshold digital signatures with different trade-offs. Our experiments show that the overhead of protecting secrets and credentials against breaches in PASTA, i.e. compared to a naive single server solution, is extremely low (1-5%) in the most likely setting where client and servers communicate over the internet. The overhead is higher in case of MAC-based tokens over a LAN (though still only a few milliseconds) due to public-key operations in PASTA. We show, however, that this cost is inherent by proving a symmetric-key only solution impossible.
Salt-Assisted Ultrasonic Deaggregation of Nanodiamond (2016)

We report a new facile, inexpensive, and contaminant-free technique of salt-assisted ultrasonic deaggregation (SAUD) of nanodiamond into single-digit particles stable in aqueous colloidal solution in a wide pH range. The technique utilizes the energy of ultrasound to break apart nanodiamond aggregates in sodium chloride aqueous slurry. In contrast to current deaggregation techniques, which introduce zirconia contaminants into nanodiamond, the single-digit nanodiamond colloids produced by SAUD have no toxic or difficult-to-remove impurities and are therefore well-suited to produce nanodiamonds for numerous applications, including theranostics, composites, and lubrication, etc. Requiring only aqueous slurry of sodium chloride and standard horn sonicator, and yielding highly pure well-dispersed nanodiamond colloids, the technique is an attractive alternative to current nanodiamond deaggregation protocols and can be easily implemented in any laboratory or scaled up for industrial use.
Possible physiological role of H19 RNA (2002)

The product of the imprinted oncofetal H19 gene is an untranslated RNA of unknown function. With the human cDNA Atlas microarray, we detected differentially expressed genes modulated by the presence of H19 RNA. Many of the genes that are upregulated by H19 RNA are known to contribute to the invasive, migratory, and angiogenic capacities of cells. Moreover, we provided experimental data indicating that whereas H19 RNA did not have any growth advantage for the cells when cultured in 10% fetal calf serum, it did confer an advantage when cells were cultured in serum-poor medium. This observation can be explained in part by the inability of the H19-expressing cells to induce the cyclin-dependent kinase inhibitor p57(kip2) in response to serum stress. Our results favor the possible role of the H19 gene in promoting cancer progression, angiogenesis, and metastasis.
Multi-Modal, Implantable Colon Activity Sensor (2022)

Continuous monitoring of bowel activity during normal daily activities would improve clinical diagnostics and understanding the mechanisms underlying bowel function or help validate interventions that alter bowel function. This work describes a colon monitor to capture activity (ColoMOCA). The ColoMOCA included two pressure sensors, three impedance-sensing electrodes, and wireless battery recharge and data transmission circuitry. Components were integrated on a flexible printed circuit board, which was encapsulated in biocompatible silicone. Packaged ColoMOCAs were 8 mm in diameter and 85 mm long. ColoMOCAs continuously transmitted sensor data at 10Hz at 30 cm range, and ran for 21 hours before wireless recharge. Acute in vivo testing in conscious pigs demonstrated ColoMOCA detected colon phasic contractions with comparable accuracy relative to wired manometry sensors. Implantations of 7 days were performed which demonstrated conscious, ambulatory monitoring of colonic behavior, including phasic stool impedance data suggesting motility detection.
Knockdown of PSD-95/SAP90 delays the development of neuropathic pain in rats (2001)

Our previous work has shown that PSD-95/SAP90 is required for NMDA receptor-mediated thermal hyperalgesia. To address the role of PSD-95/SAP90 in chronic pain, the present study investigated the effect of the deficiency of PSD-95/SAP90 on nerve injury-induced neuropathic pain. Following unilateral L5 spinal nerve injury, mechanical and thermal hyperalgesia developed within 3 days and persisted for 9 days or longer on the injured side. The intrathecal administration of antisense oligodeoxynucleotide specifically against PSD-95/SAP90, but not sense or missense oligodeoxynucleotide, dose-dependently delayed the onset of tactile allodynia and thermal hyperalgesia. These results suggest that PSD-95/SAP90 might be involved in the central mechanisms of the development of chronic neuropathic pain.
Migration velocity analysis by migration of velocity spectra (1991)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1991Migration velocity analysis by migration of velocity spectraAuthors: Craig J. BeasleyRolf KlotzCraig J. BeasleyWestern Atlas International, Singapore and Rolf KlotzWestern Atlas International, Singaporehttps://doi.org/10.1190/1.1888706 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1888706FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1991ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1991 Pages: 1646 publication data© 1991 Copyright © 1991 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Craig J. Beasley and Rolf Klotz, (1991), "Migration velocity analysis by migration of velocity spectra," SEG Technical Program Expanded Abstracts : 1239-1242. https://doi.org/10.1190/1.1888706 Plain-Language Summary PDF DownloadLoading ...
USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment (2016)

Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. Most endometrial cancer cases are diagnosed at an early stage and have good prognosis. Unfortunately a subset of patients with early stage and low grade disease experience recurrence for reasons that remain unclear. Recurrence is often accompanied by chemoresistance and high mortality.Deubiquitinating enzymes (DUBs) are key components of the ubiquitin-dependent protein degradation pathway and act as master regulators in a number of metabolic processes including cell growth, differentiation, and apoptosis. DUBs have been shown to be upregulated in a number of human cancers and their aberrant activity has been linked to cancer progression, initiation and onset of chemoresistance. Thus, selective inhibition of DUBs has been proposed as a targeted therapy for cancer treatment.This study suggests the DUB USP14 as a promising biomarker for stratifying endometrial cancer patients at diagnosis based on their risk of recurrence. Further USP14 is expressed along with the marker of proliferation Ki67 in endometrial cancer cells in situ. Lastly, pharmacological targeting of USP14 with the FDA approved small-molecule inhibitor VLX1570, decreases cell viability in chemotherapy resistant endometrial cancer cells with a mechanism consistent with cell cycle arrest and caspase-3 mediated apoptosis.
Adaptive bilateral matching for decoder-side motion vector refinement in video coding (2022)

This paper presents an adaptive bilateral matching technique for decoder-side motion vector refinement in video coding. It allows encoder to choose not only the conventional bilateral matching mode with symmetric motion vector difference but also the asymmetric alternatives. To study the efficiency of the proposed technique, the proposed method is integrated in the Versatile Video Coding Test Model 11.0. The experimental result reports an overall of −2.78% luma Bjontegaard Delta rate for the random-access configurations. The compression efficiency on top of the Enhanced Compression Model that beyond the VVC capability are also reported.
Handwritten Signature Verification Using Hand-Worn Devices (2016)

Online signature verification technologies, such as those available in banks and post offices, rely on dedicated digital devices such as tablets or smart pens to capture, analyze and verify signatures. In this paper, we suggest a novel method for online signature verification that relies on the increasingly available hand-worn devices, such as smartwatches or fitness trackers, instead of dedicated ad-hoc devices. Our method uses a set of known genuine and forged signatures, recorded using the motion sensors of a hand-worn device, to train a machine learning classifier. Then, given the recording of an unknown signature and a claimed identity, the classifier can determine whether the signature is genuine or forged. In order to validate our method, it was applied on 1980 recordings of genuine and forged signatures that we collected from 66 subjects in our institution. Using our method, we were able to successfully distinguish between genuine and forged signatures with a high degree of accuracy (0.98 AUC and 0.05 EER).
A field‐sequential color VGA AMEL display (1997)

Abstract— A 0.7‐inch‐diagonal full‐color VGA active‐matrix EL display using a liquid‐crystal color shutter to provide field‐sequential filtering of the broadband EL emission is reported. The shutter's color‐filter design improves the color gamut of AMEL displays using the SrS: Ce/ZnS: Mn EL phosphor. A digital gray‐scale addressing scheme achieves 256 colors using temporal binary shading combined with error diffusion.
Pyrazolo[1,5-<i>a</i>]-1,3,5-triazine C-Nucleoside as Deoxyadenosine Analogue: Synthesis, Pairing, and Resistance to Hydrolysis (2014)

The synthesis of a pyrazolo[1,5-a]-1,3,5-triazine C-nucleoside (dA(PT)), designed to form two hydrogen bonds with a complementary dT residue, is reported. Oligonucleotides including this dA nucleoside analogue possess base-pairing properties similar to those of the parent oligonucleotide. This dA nucleoside analogue is more resistant to acid-catalyzed hydrolysis than dA.
Optical characterization of high quality two dimensional photonic crystal cavities (2003)

Summary form only given. Photonic crystal nanocavities have recently attracted much attention because such cavities are predicted to provide the desired combination of both small mode volume and high Q values. In this presentation, we report the experimental demonstration that by using fractional edge dislocations in photonic crystal cavities, it is possible to construct microcavities with high Qs as well as small mode volumes.
The <i>Caenorhabditis elegans</i> cell death gene <i>ced-4</i> encodes a novel protein and is expressed during the period of extensive programmed cell death (1992)

Mutations in the gene ced-4 block almost all of the programmed cell deaths that normally occur during Caenorhabditis elegans development. We have cloned the ced-4 gene using a ced-4 mutation caused by the insertion of the transposon Tc4. When microinjected into a ced-4 animal, a 4.4 kb DNA fragment derived from the wild-type strain and corresponding to the region of the Tc4 insertion in the mutant ced-4(n1416) rescues the Ced-4 mutant phenotype. The ced-4 gene encodes a 2.2 kb RNA transcript. This mRNA is expressed primarily during embryogenesis, when most programmed cell deaths occur. The Ced-4 protein, as deduced from cDNA and genomic DNA clones, is 549 amino acids in length. Two regions of the putative Ced-4 protein product show some similarity to known calcium-binding domains.
Partially bonded fiber-reinforced elastomeric isolators (PB-FREIs) (2014)

Although stable unbonded fiber-reinforced elastomeric isolators (SU-FREIs) have desirable characteristics for seismic isolation, the unbonded application also introduces limitations in comparison with bonded elastomeric isolators. SU-FREIs are not capable of resisting tensile forces, making SU-FREIs unsuited for situations where overturning is of concern or where large vertical accelerations are anticipated. Furthermore, as SU-FREIs rely on friction to transfer horizontal forces, the isolator could potentially slip under certain loading conditions, resulting in permanent displacements. This paper proposes that concerns over the transfer of tensile forces and potential slip can be addressed by partially bonding the SU-FREI to the upper and lower supports. In this way, partially bonded FREIs (PB-FREIs) not only retain the beneficial characteristics of an unbonded FREI but also inherit characteristics of a bonded isolator; notably tensile and horizontal forces can be transferred through the partial bond. Experimental results from isolators tested unbonded and partially bonded under vertical compression are used to evaluate a finite element model. The experimental data and finite element analysis demonstrate that portions of a FREI can be bonded without substantially altering the rollover characteristics of the isolator within the range of average vertical compressive and tensile stresses considered. Despite an unconventional deformed shape under tensile vertical stress, the horizontal force–displacement relationship exhibits negligible deviation from a conventional unbonded SU-FREI under a compressive vertical stress. It is postulated that with further development, partially bonded FREIs can retain the beneficial characteristics of unbonded FREIs while addressing concerns over tensile forces and slip. Copyright © 2014 John Wiley & Sons, Ltd.
Development of Two-Step Softening Heat Treatment for Manufacturing 12Cr-ODS Ferritic Steel Tubes (2004)

The 12Cr-oxide dispersion strengthened (ODS) ferritic steel is being developed as prospective cladding materials for attaining higher burnup and higher coolant outlet temperature in advanced fast reactor. Ductility and high temperature strength in the hoop direction can be attained by recrystallization in the manufactured tube of 12Cr-ODS ferritic steels. In this study, it was found that once recrystallization has taken place during manufacturing process with four passes cold rolling and intermediate heat treatment, the recrystallized condition can not be repeated at the final heat treatment. Thus, the unique two-step softening heat treatment was developed as the intermediate heat treatment; the first step heat treatment relieves the strain energy accumulated by cold rolling to raise the recrystallization temperature, and the subsequent second step heat treatment at the temperature, which is higher than the recrystallization temperature before relieving the work strain energy, accelerates the hardness reduction without recrystallization. This process leads to easy cold rolling and complete recrystallization at the final heat treatment.
Magnetic memory with a switchable reference layer (2018)

Spin-Transfer-Torque Magnetic Random Access Memory (STT-MRAM) is a memory which has bit cells made of magnetic tunnel junctions (MTJs), which comprise a storage switchable magnetic layer (“free layer”) and, typically, one thin insulating barrier and one stable magnetic layer providing reference spin polarization for read and write operations (“reference layer”). STT-MRAM may compete with conventional dynamic and static RAM on technological nodes below 22 nm, if its switching current is reduced. This goal may be achieved for MTJ, which has two insulating barriers and reference layers. Building such a double-barrier MTJ, however, faces tremendous material challenges. In this work, a new double-barrier MTJ design with a switchable reference layer is introduced. We show that its efficiency is similar to its counterpart with stable reference layers, but it is much easier to be built.
An invertase fragment responsible for improving the protein stability of dry white wines (1999)

The thermoprotective effect of yeast parietal mannoproteins improves the protein stability of white wines aged on their lees (sur lie). The substance responsible for this is an N-glycosylated, 31.8 kDa mannoprotein that corresponds to a parietal invertase fragment of Saccharomyces cerevisiae. This mannoprotein is released into the wine during autolysis of the lees by the combined action of β-glucanases from the cell wall and the yeast's vacuolar protease. This mannoprotein may be obtained industrially by extracting yeast mannoproteins using enzymatic digestion of the cell wall with commercially prepared β-glucanases (GlucanexTM -Novo-Nordisk). A wine's susceptibility to protein breakdown may be considerably reduced by adding this mannoprotein extract. As a result, less bentonite is needed to stabilise the wine. © 1999 Society of Chemical Industry
Remote laser welding of zinc-coated sheet metal component in a lap configuration utilizing humping effect (2010)

With the advancement of high power fiber-delivery lasers, remote laser welding becomes a reality and more and more systems have been introduced into production lines. Remote laser welding takes the advantages of less mechanical movement and better accessibility of the beam to the workpiece, thus fast processing speed can be achieved. In most cases, remote laser welding involves lap welding. Laser beam lap welding of zinc coated steel components is not a straightforward process and it requires a special procedure to provide proper venting for the zinc vapour which is generated during welding in the interface. Although there are many approaches to address this issue, many of the approaches are either impractical or too costly to apply to remote laser beam welding in production. Humping effect is an adverse effect that limits the achievable welding speed in laser beam welding. However, it has been demonstrated in the experiment that the height of the protuberance in the humping effect can be controlled via proper process parameters and an optimal height in the range of 0.1 – 0.2 mm can be achieved to meet vapour venting requirement. In reality, the optimum gap size is depending on material thickness and coating type. As a result, the high-speed humping effect can be advantageously used as a pre-process to provide proper gap for laser beam lap welding of zinc coated sheet metals. Furthermore, this pre-process can be naturally implemented in the remote laser welding process flow. The whole process is very flexible and can be achieved at very high speed.