gebhart/patrepeval huggingface dataset:
ZVS Turn-on Triangular Current Mode (TCM) Control for Three Phase 2-Level Inverters with Reactive Power Control (2018)

Critical conduction mode (CRM)/ Triangular current mode (TCM) control with ZVS turn-on for single phase inverters has led to significant improvement in efficiency at high switching frequencies (>300 kHz). The need to push power converters to high switching frequencies comes from the drive to achieve higher power density as high frequency operation leads to a significant decrease in filter volume which consumes most of the space in power converter systems. With recent advancements in wide bandgap devices' technology, it is possible to operate at high switching frequencies with very low turn-off losses (<;5 W for a 1.2 kW three phase 2-level GaN inverter at 1 MHz switching frequency). A huge increase in power density (from 30 W/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> to 80 W/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) is achieved by pushing the switching frequency to MHz range. The turn-on losses in hard switching continuous conduction mode (CCM) though are still significant (>40 W for the above specified operating conditions). Thus, making it necessary to operate the inverter with zero voltage switching (ZVS) turn-on. ZVS turn-on with TCM control for three phase boost PFC has been recently presented, it is shown in this paper how this method can be extended to inverters. However, this new control scheme cannot be just limited to unity power factor operation and reactive power control becomes all the more necessary for inverters as the grid can have reactive loads or reactive power requirements. TCM control with ZVS turn-on in inverter mode for full range of power factor is presented in this paper. It is also shown that even with higher ripple, TCM maintains similar efficiency at 1 MHz as CCM in 50 KHz while achieving 3× power density.
Moisture damage in asphalt concrete (1991)

This synthesis will be of interest to pavement designers, construction engineers, maintenance engineers, and others interested in avoiding or limiting moisture damage in asphalt concrete. Information is provided on physical and chemical explanations for moisture damage in asphalt concrete, along with a discussion of current practices and test methods for determining or reducing the susceptibility of various asphalt concrete components and mixtures to such damage. Moisture damage in asphalt concrete is a nationwide problem which often necessitates premature replacement of highway pavement surfaces. This report of the Transportation Research Board describes the underlying physical and chemical phenomena responsible for such damage. Current test methods used to determine the susceptibility of asphalt concretes, or their constituents, to moisture damage are described and evaluated. Additionally, current practices for minimizing the potential for moisture damage are examined.
Antifungal Metabolites from the Marine Sponge <i>Pachastrissa</i> sp.:  New Bengamide and Bengazole Derivatives (1999)

This paper reports the studies of components of an undescribed sponge in the genus Pachastrissa sp., collected along the Djibouti coast. The extract showed activity against Candida albicans. Six new bengazoles (1-6) and a new bengamide, named bengamide L (16), in addition to the known bengazoles (7-11), bengamides A (12), B (13), E (14), and F (15), and a lactone (17) are described in this paper. All structures were determined on the basis of spectroscopic studies.
Demonstration of an interactive multimedia environment (1994)

The images in this article tell the story of one user's experience with a virtual reality environment that promotes collaboration and learning.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Body surface Laplacian ECG mapping (1992)

A new noninvasive approach has been developed to resolve spatially distributed cardiac electrical activity by measuring the surface Laplacian of the body surface potential. Computer simulations demonstrate the ability of the Laplacian map compared with the potential map to image spatially distributed dipole sources embedded in a semi-infinite volume conductor. Body surface Laplacian mapping has been implemented in human subjects utilizing dry bipolar Laplacian electrodes and compared with potential maps obtained using the central terminal of each bipolar Laplacian electrode. The body surface Laplacian ECG distribution was found to provide better spatial resolution than the body surface potential distribution. The body surface Laplacian map appears to resolve depolarization and repolarization of different regions of the heart. Further improvements of the body surface Laplacian mapping may permit noninvasive mapping of spatially distributed intracardiac events.
Elastic Behavior of Cross-Linked and Bundled Actin Networks (2004)

Networks of cross-linked and bundled actin filaments are ubiquitous in the cellular cytoskeleton, but their elasticity remains poorly understood. We show that these networks exhibit exceptional elastic behavior that reflects the mechanical properties of individual filaments. There are two distinct regimes of elasticity, one reflecting bending of single filaments and a second reflecting stretching of entropic fluctuations of filament length. The mechanical stiffness can vary by several decades with small changes in cross-link concentration, and can increase markedly upon application of external stress. We parameterize the full range of behavior in a state diagram and elucidate its origin with a robust model.
Effect of casomorphin on gastric acid secretion and study of its molecule function in 21 days' weaning piglets (2005)

Compared with control group (pH=5.08±0.43), average pH of piglets fed #beta#-CM-7 or saline was 2.76±0.51 and 4.26±0.62, respectively. The pH values of experiment groups were lower than that of control group. The gastrin of the #beta#-CM-7 group was the highest (100.03±18.72 pg/mL) and that of the control group was lowest (75.92±11.86 pg/mL), and the difference was significant. Compared with the control group, that the gastrin mRNA in gastric antrum of the 21st day's weaning piglet fed with #beta#-CM-7 increased significantly. Early weaning grou was a little higher than the control. The change of gastrin mRNA in duodenum was similar with gastric antrum. The result of this study demonstrated that the #beta#-CM-7 could stimulate the gastrin secretion of gastric antrum and duodenum by means of improving the gene expression of gastrin in 21 days' weaning piglets.
Christina Currie, Bart Fransen u. a. (Hrsg.); Van Eyck Studies. Papers Presented at the Eighteenth Symposium for the Study of Underdrawing and Technology in Painting (2021)

Rezension zu: Christina Currie, Bart Fransen u. a. (Hrsg.); Van Eyck Studies. Papers Presented at the Eighteenth Symposium for the Study of Underdrawing and Technology in Painting; Brussels, 19–21 September 2012; Leuven: Peeters Publishers 2017; 598 S.; ISBN 978-90-429-3415-3
Fluorescence Quenching by Nucleotides of the Plasma Membrane H<sup>+</sup>-ATPase from <i>Kluyveromyces lactis</i> (2007)

The yeast plasma membrane H+-ATPase isolation procedure was improved; a highly pure enzyme (90-95%) was obtained after centrifugation on a trehalose concentration gradient. H+-ATPase kinetics was slightly cooperative: Hill number = 1.5, S0.5 = 800 microM ATP, and turnover number = 36 s-1. In contrast to those of other P-type ATPases, H+-ATPase fluorescence was highly sensitive to nucleotide binding; the fluorescence decreased 60% in the presence of both 5 mM ADP and AMP-PNP. Fluorescence titration with nucleotides allowed calculation of dissociation constants (Kd) from the binding site; Kd values for ATP and ADP were 700 and 800 microM, respectively. On the basis of amino acid sequence and homology model analysis, we propose that binding of the nucleotide to the N-domain is coupled to the movement of a loop beta structure and to the exposure of the Trp505 residue located in the loop. The recombinant N-domain also displayed a large hyperbolic fluorescence quenching when ATP binds; however, it displayed a higher affinity for ATP (Kd = 100 microM). We propose for P-type ATPases that structural movements during nucleotide binding could be followed if a Trp residue is properly located in the N-domain. Further, we propose the use of trehalose in enzyme purification protocols to increase the purity and quality of the isolated protein and to perform structural studies.
A fault detection service for wide area distributed computations (2002)

The potential for faults in distributed computing systems is a significant complicating factor for application developers. While a variety of techniques exist for detecting and correcting faults, the implementation of these techniques in a particular context can be difficult. Hence, we propose a fault detection service designed to be incorporated, in a modular fashion, into distributed computing systems, tools, or applications. This service uses well-known techniques based on unreliable fault detectors to detect and report component failure, while allowing the user to tradeoff timeliness of reporting against false positive rates. We describe the architecture of this service, report on experimental results that quantify its cost and accuracy, and describe its use in two applications, monitoring the status of system components of the GUSTO computational grid testbed and as part of the NetSolve network-enabled numerical solver.
A Heterologous Reporter Defines the Role of the Tetanus Toxin Interchain Disulfide in Light-Chain Translocation (2015)

Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for humans and elicit unique pathologies due to their ability to traffic within motor neurons. BoNTs act locally within motor neurons to elicit flaccid paralysis, while retrograde TeNT traffics to inhibitory neurons within the central nervous system (CNS) to elicit spastic paralysis. BoNT and TeNT are dichain proteins linked by an interchain disulfide bond comprised of an N-terminal catalytic light chain (LC) and a C-terminal heavy chain (HC) that encodes an LC translocation domain (HCT) and a receptor-binding domain (HCR). LC translocation is the least understood property of toxin action, but it involves low pH, proteolysis, and an intact interchain disulfide bridge. Recently, Pirazzini et al. (FEBS Lett 587:150-155, 2013, http://dx.doi.org/10.1016/j.febslet.2012.11.007) observed that inhibitors of thioredoxin reductase (TrxR) blocked TeNT and BoNT action in cerebellar granular neurons. In the current study, an atoxic TeNT LC translocation reporter was engineered by fusing β-lactamase to the N terminus of TeNT [βlac-TeNT(RY)] to investigate LC translocation in primary cortical neurons and Neuro-2a cells. βlac-TeNT(RY) retained the interchain disulfide bond, showed ganglioside-dependent binding to neurons, required acidification to promote βlac translocation, and was sensitive to auranofin, an inhibitor of thioredoxin reductase. Mutation of βlac-TeNT(RY) at C439S and C467S eliminated the interchain disulfide bond and inhibited βlac translocation. These data support the requirement of an intact interchain disulfide for LC translocation and imply that disulfide reduction is a prerequisite for LC delivery into the host cytosol. The data also support a model that LC translocation proceeds from the C to the N terminus. βlac-TeNT(RY) is the first reporter system to measure translocation by an AB single-chain toxin in intact cells.
A brief account of nanoparticle contrast agents for photoacoustic imaging (2013)

Photoacoustic imaging (PAI) is a hybrid, nonionizing modality offering excellent spatial resolution, deep penetration, and high soft tissue contrast. In PAI, signal is generated based on the absorption of laser-generated optical energy by endogenous tissues or exogenous contrast agents leading to acoustic emissions detected by an ultrasound transducer. Research in this area over the years has shown that PAI has the ability to provide both physiological and molecular imaging, which can be viewed alone or used in a hybrid modality fashion to extend the anatomic and hemodynamic sensitivities of clinical ultrasound. PAI may be performed using inherent contrast afforded by light absorbing molecules such as hemoglobin, myoglobin, and melanin or exogenous small molecule contrast agent such as near infrared dyes and porphyrins. However, this review summarizes the potential of exogenous nanoparticle-based agents for PAI applications including contrast based on gold particles, carbon nanotubes, and encapsulated copper compounds.
Challenges in the Delivery of Peptide drugs: an Industry Perspective (2015)

Due mainly to their poor stability and short plasma half-life, peptides are usually administered by injection, often several times daily. Injectable sustained-release formulations of peptides based on biodegradable polymer microparticles or implants early demonstrated the power of drug delivery technologies to enhance patient adherence and convenience, and increase safety and efficacy. Injectable sustained-release formulations are likely to remain a significant part of new peptide products. However, a new generation of technologies that enable solvent-free formulations and manufacturing processes, injection through narrow gauge needles and ready-to-use presentations will be increasingly used. In addition, the tremendous developments in noninvasive routes of delivery are likely to result in more and more peptides being delivered by the oral, transdermal, nasal or inhalation routes.
Fault-Tolerant Design for VLSI: Effect of Interconnect Requirements on Yield Improvement of VLSI Designs (1982)

In order to take full advantage of VLSI, new design methods are necessary to improve the yield and testability. Designs which incorporate redundancy to improve the yields of high density memory chips are well known. The goal of this paper is to motivate the extension of this technique to other types of VLSI logic circuits. The benefits and the limitations of on-chip modularization and the use of spare elements are presented, and significant yield improvements are shown to be possible.
Preparation and nutritional properties of caseins covalently modified with sugars. Reductive alkylation of lysines with glucose, fructose, or lactose (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and nutritional properties of caseins covalently modified with sugars. Reductive alkylation of lysines with glucose, fructose, or lactoseHonson S. Lee, Lourminia C. Sen, Andrew J. Clifford, John R. Whitaker, and Robert E. FeeneyCite this: J. Agric. Food Chem. 1979, 27, 5, 1094–1098Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://pubs.acs.org/doi/10.1021/jf60225a045https://doi.org/10.1021/jf60225a045research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
BOLD fMRI effects of transcutaneous vagus nerve stimulation in patients with chronic tinnitus (2018)

tVNS via the inner tragus or cymba conchae suppressed neural activity in the auditory, limbic, and other tinnitus-related non-auditory areas through auditory and vagal ascending pathways in tinnitus patients. The results from this study are discussed in the context of several existing models of tinnitus. They indicate that the mechanism of action of tVNS might be involved in multiple brain areas responsible for the generation of tinnitus, tinnitus-related emotional annoyance, and their mutual reinforcement.
Postfilters to Modify the Modulation Spectrum for Statistical Parametric Speech Synthesis (2016)

This paper presents novel approaches based on modulation spectrum (MS) for high-quality statistical parametric speech synthesis, including text-to-speech (TTS) and voice conversion (VC). Although statistical parametric speech synthesis offers various advantages over concatenative speech synthesis, the synthetic speech quality is still not as good as that of concatenative speech synthesis or the quality of natural speech. One of the biggest issues causing the quality degradation is the over-smoothing effect often observed in the generated speech parameter trajectories. Global variance (GV) is known as a feature well correlated with the over-smoothing effect, and the effectiveness of keeping the GV of the generated speech parameter trajectories similar to those of natural speech has been confirmed. However, the quality gap between natural speech and synthetic speech is still large. In this paper, we propose using the MS of the generated speech parameter trajectories as a new feature to effectively quantify the over-smoothing effect. Moreover, we propose postfilters to modify the MS utterance by utterance or segment by segment to make the MS of synthetic speech close to that of natural speech. The proposed postfilters are applicable to various synthesizers based on statistical parametric speech synthesis. We first perform an evaluation of the proposed method in the framework of hidden Markov model (HMM)-based TTS, examining its properties from different perspectives. Furthermore, effectiveness of the proposed postfilters are also evaluated in Gaussian mixture model (GMM)-based VC and classification and regression trees (CART)-based TTS (a.k.a., CLUSTERGEN). The experimental results demonstrate that 1) the proposed utterance-level postfilter achieves quality comparable to the conventional generation algorithm considering the GV, and yields significant improvements by applying to the GV-based generation algorithm in HMM-based TTS, 2) the proposed segment-level postfilter capable of achieving low-delay synthesis also yields significant improvements in synthetic speech quality, and 3) the proposed postfilters are also effective in not only HMM-based TTS but also GMM-based VC and CLUSTERGEN.
Sarcoidosis Associated with Acute Renal Failure and Increased Levels of Interleukin-6 in Urine. (1998)

A 24-year-old man who had uveitis and showed intrathoracic lymph node swelling on a chest X-ray, was admitted to our hospital for further examination. Transbronchial lung biopsy specimens revealed non-caseating granulomas compatible to sarcoidosis. As the renal function became progressively worse, a specimen was obtained by renal biopsy. It showed a granuloma formation, and was diagnosed as renal sarcoidosis. A high level of interleukin (IL)-6 was detected in his urine. After oral administration of prednisolone, the renal function improved, and the urinary IL-6 level was reduced. These findings suggest that in sarcoidosis associated with renal failure, steroid therapy is effective and that IL-6 plays an important role in the pathogenesis of renal involvement of sarcoidosis.
Microcontroller Idea Book: Circuits, Programs and Applications Featuring the 8052-Basic Single-Chip Computer (1997)

A significantly reduced sense of personal accomplishment occurred commonly in a studied group of physiotherapists. Professional burnout is most likely to occur in men, in people with higher education, in those working in hospital departments with more work experience, and those in a poor financial situation. Employers should take care of their employees' mental health as a part of burnout prophylaxis.
Sensor‐Driven Rate Smoothing in a DDDR Pacemaker (1989)

DDD pacemakers may have large cycle-to-cycle variations in rate at the upper rate limit because of 2:1 block or Wenckebach-type block. Rate smoothing was introduced as an option to eliminate these large variations. Now, DDDR pacemakers can produce similar electrocardiographic displays through a different mechanism that uses an activity sensor. This is termed "sensor-driven rate smoothing" because it occurs only when the activity sensor is driving the pacemaker. In the case described, as the atrial rate exceeded the maximum tracking rate and reverted to Wenckebach-type block, the RR interval varied only from 600 msec to 680 msec (13.3% rate-smoothing value) because of sensor-driven pacing. Maximal sensor-driven rate smoothing requires optimal programming of the rate response indicators. This sensor-driven rate-smoothing effect is an electrocardiographic manifestation that will undoubtedly be seen more frequently as DDDR devices come into widespread clinical use.
The Validity of Functional Behavioral Assessment with Students of Average Intellectual Ability (2000)

In the United States, functional behavioral assessment (FBA) is a new requirement of the 1997 Amendments to Individuals with Disabilities Education Act for students who exhibit challenging behavior. FBA has been extensively studied with persons with severe and profound intellectual disabilities within clinical settings. However, there is limited research with students with average intellectual ability in public education settings. This article reviews seven pertinent validity indices associated with FBA: external validity, content validity, convergent validity, criterion validity, treatment validity, social validity, and habilitative validity. In short, much research is needed to inform practitioners about conducting valid FBAwith students with average intellectual ability.
Optimal illumination spectrum for endoscope (2011)

Color differences are determined by illumination, the spectral reflectance of objects, and the spectral sensitivity of the imaging sensor. In this paper, we explore the optimal illumination conditions that best separate one object from another. Given two objects with distinct spectra, we derive the optimal illumination spectrum to maximize their color distance with a plain RGB camera. In practice, it is crucial to compose the most appropriate illuminations using available lighting sources since creating arbitrary illumination spectrum is unrealistic. Therefore, we derive the optimal linear combination of the provided illumination sources. Finally, we verify the effectiveness of the methods through experiments.