gebhart/patrepeval huggingface dataset:
Howling Suppression in Hearing Aids Using Least-Squares Estimation and Perceptually Motivated Gain Control (2006)

Howling is a significant problem even in digital hearing aids equipped with adaptive feedback cancellation. Among the many causes of howling is the inability of the adaptive filter to track rapid changes in the feedback path. Many systems use howling detectors to detect the start of howling and reduce the hearing aid gain for several seconds to avoid prolonged howling. Unfortunately the inadequate speech pressure levels (SPL) during times when the gain is reduced causes loss of information and reduced intelligibility of speech signals arriving at the patient's ears. This paper presents a new method that switches to a least-squares adaptation scheme with linear complexity at the onset of howling. The method adapts to the altered feedback path quickly and allows the patient to not lose perceivable information. The complexity of the least-squares estimate is reduced by reformulating the least-squares estimate into a Toeplitz system and solving it with a direct Toeplitz solver. In addition, the gain function is changed immediately after howling detection in such a way that the system operates in a stable manner and the distortions caused are not perceived because of temporal masking. Simulation results comparing with a conventional method is presented in the paper to demonstrate the superior howling suppression capabilities of the method
Evidence that a new enterotoxin of Escherichia coli which activates adenylate cyclase in eucaryotic target cells is not plasmid mediated (1983)

Escherichia coli SA53 produces a new enterotoxin that has a biological activity similar to that of E. coli heat-labile enterotoxin (LT) but is not neutralized by antiserum against LT or cholera enterotoxin. Strain SA53 contained two plasmids, pRB1 (69.2 +/- 4.3 megadaltons) and pRB2 (57.6 +/- 5.3 megadaltons). Studies were undertaken to determine whether either plasmid was required for production of the LT-like toxin. We isolated a derivative of SA53 lacking both plasmids and confirmed that radioactively labeled pRB1 and pRB2 DNAs failed to hybridize to total DNA digests of the cured strain. The new enterotoxin was still produced by the cured strain, demonstrating that the gene(s) encoding the toxin was not located on pRB1 or pRB2 and was most likely on the bacterial chromosome. Although sonic extracts from SA53 contained no detectable LT antigen, plasmid pRB1 DNA did contain sequences with partial homology to the LT-A and LT-B genes. No sequence homology with LT genes was detected with pRB2 DNA. When the enterotoxin plasmid pCG86 was introduced into a rifampin-resistant derivative of SA53, LT was produced. Thus, plasmid-coded LT could be produced in the E. coli SA53 host, and the sequences homologous to LT in pRB1 were cryptic.
First-in-Human Clinical Application of the Medyria TrackCath System in Endovascular Repair of Complex Aortic Aneurysms (ACCESS Trial): A Prospective Multicenter Single-Arm Clinical Trial (2021)

The ACCESS Trial suggests that BFV measurement allows for reliable target orifice identification and catheterization. The use of MedTCC is safe and generates short fluoroscopy time and low contrast agent use, which in turn might facilitate complex endovascular procedures.
VOLATILE ORGANIC COMPOUND (VOC) REMOVAL BY ADSORPTION ONTO ACTIVATED CARBON FIBER CLOTH AND ELECTROTHERMAL DESORPTION: AN INDUSTRIAL APPLICATION (2006)

ABSTRACT Previous studies have shown good adsorption of volatile organic compounds (VOC) present in air onto activated carbon fiber cloths (ACFCs). In a chemical plant, a treatment process was carried out to control a gaseous emission (flow close to 100 m3 h−1) loaded with methylene chloride at concentrations ranging between 3 and 30 g m−3. A final mass flow lower than 100 g h−1 was required in the outlet emission. Two identical cylindrical ACFC modules worked alternately in an adsorption-desorption cycle. The outlet pollutant mass flow was found to be less than 4 g h−1. After saturation of the adsorbent, the module was electrothermally regenerated. Desorbed methylene chloride was recovered in a cryogenic trap and reused in the chemical processes of the plant. This system worked continuously for more than 18 months (24 h per day) with no operating problems and giving good performance in terms of VOC outlet emission concentrations.
Screening Strategies for Autism Spectrum Disorders in Pediatric Primary Care (2008)

The PEDS missed the majority of children who screened positive for ASD on the M-CHAT, suggesting that these two tools tap into very different domains of developmental concerns. The findings support the use of an ASD-specific tool for all children in conjunction with regular standardized developmental screening.
<sup>19</sup>F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells (2011)

Current diagnosis of organ rejection following transplantation relies on tissue biopsy, which is not ideal due to sampling limitations and risks associated with the invasive procedure.We have previously shown that cellular magnetic resonance imaging (MRI) of iron-oxide labeled immune-cell infiltration can provide a noninvasive measure of rejection status by detecting areas of hypointensity on T 2*-weighted images. In this study, we tested the feasibility of using a fluorine-based cellular tracer agent to detect macrophage accumulation in rodent models of acute allograft rejection by fluorine-19 ((19) F) MRI and magnetic resonance spectroscopy. This study used two rat models of acute rejection, including abdominal heterotopic cardiac transplant and orthotopic kidney transplant models. Following in vivo labeling of monocytes and macrophages with a commercially available agent containing perfluoro-15-crown-5-ether, we observed (19) F-signal intensity in the organs experiencing rejection by (19) F MRI, and conventional (1) H MRI was used for anatomical context. Immunofluorescence and histology confirmed macrophage labeling. These results are consistent with our previous studies and show the complementary nature of the two cellular imaging techniques. With no background signal, (19) F MRI/magnetic resonance spectroscopy can provide unambiguous detection of fluorine labeled cells, and may be a useful technique for detecting and quantifying rejection grade in patients.
Synthesis, characterization, and biological evaluation of poly(L-&amp;gamma;-glutamyl-glutamine)-paclitaxel nanoconjugate (2010)

Sang Van1, Sanjib K Das1, Xinghe Wang1, Zhongling Feng1, Yi Jin1, Zheng Hou1, Fu Chen1, Annie Pham1, Nan Jiang1, Stephen B Howell2, Lei Yu11Nitto Denko Technical Corporation, Oceanside, CA, USA; 2Moores Cancer Center, University of California, La Jolla, San Diego, CA, USAAbstract: The purpose of this study was to develop a novel, highly water-soluble poly(L-&amp;gamma;-glutamyl-glutamine)-paclitaxel nanoconjugate (PGG-PTX) that would improve the therapeutic index of paclitaxel (PTX). PGG-PTX is a modification of poly(L-glutamic acid)-paclitaxel conjugate (PGA-PTX) in which an additional glutamic acid has been added to each glutamic side chain in the polymer. PGG-PTX has higher water-solubility and faster dissolution than PGA-PTX. Unlike PGA-PTX, PGG-PTX self-assembles into nanoparticles, whose size remains in the range of 12&amp;ndash;15 nm over the concentration range from 25 to 2,000 &amp;micro;g/mL in saline. Its critical micellar concentration in saline was found to be ~25 &amp;micro;g/mL. The potency of PGG-PTX when tested in vitro against the human lung cancer H460 cell line was comparable to other known polymer-PTX conjugates. However, PGG-PTX possesses lower toxicity compared with PGA-PTX in mice. The maximum tolerated dose of PGG-PTX was found to be 350 mg PTX/kg, which is 2.2-fold higher than the maximum tolerated dose of 160 mg PTX/kg reported for the PGA-PTX. This result indicates that PGG-PTX was substantially less toxic in vivo than PGA-PTX.Keywords: nanoconjugates, poly(L-glutamic acid), poly(L-&amp;gamma;-glutamyl-glutamine)-paclitaxel, nanoparticles, anticancer
Topical Review: Development of overgrown semi-polar GaN for high efficiency green/yellow emission (2016)

The most successful example of large lattice-mismatched epitaxial growth of semiconductors is the growth of III-nitrides on sapphire, leading to the award of the Nobel Prize in 2014 and great success in developing InGaN-based blue emitters. However, the majority of achievements in the field of III-nitride optoelectronics are mainly limited to polar GaN grown on c-plane (0001) sapphire. This polar orientation poses a number of fundamental issues, such as reduced quantum efficiency, efficiency droop, green and yellow gap in wavelength coverage, etc. To date, it is still a great challenge to develop longer wavelength devices such as green and yellow emitters. One clear way forward would be to grow III-nitride device structures along a semi-/non-polar direction, in particular, a semi-polar orientation, which potentially leads to both enhanced indium incorporation into GaN and reduced quantum confined Stark effects. This review presents recent progress on developing semi-polar GaN overgrowth technologies on sapphire or Si substrates, the two kinds of major substrates which are cost-effective and thus industry-compatible, and also demonstrates the latest achievements on electrically injected InGaN emitters with long emission wavelengths up to and including amber on overgrown semi-polar GaN. Finally, this review presents a summary and outlook on further developments for semi-polar GaN based optoelectronics.
Enabling secure query processing in the cloud using fully homomorphic encryption (2013)

The database community, at least for the last decade, has been grappling with querying encrypted data, which would enable secure database as a service solutions. A recent breakthrough in the cryptographic community (in 2009) related to fully homomorphic encryption (FHE) showed that arbitrary computation on encrypted data is possible. Successful adoption of FHE for query processing is, however, still a distant dream, and numerous challenges have to be addressed. One challenge is how to perform algebraic query processing of encrypted data, where we produce encrypted intermediate results and operations on encrypted data can be composed. In this paper, we describe our solution for algebraic query processing of encrypted data and outline several other challenges that need to be investigated, while also describing the lessons that can be learnt from a decade of work by database community in querying encrypted data.
Inervación vesical no adrenérgica-no colinérgica (2006)

Ademas de la inervacion simpatica y parasimpatico, a nivel del tracto urinario inferior (LUT) hay actividad no adrenergica no colinergica (NANC) especialmente relacionada con receptores purinergicos y del oxido nitrico. Por otro lado, se sabe que hay muchos otros mediadores implicados con menor importancia, como pueden ser el peptido intestinal vasoactivo (VIP), encefalinas, galamina, acido gammaaminobutirico (GABA), etc. Por el gran numero de sustancias implicadas en la dinamica continencia-miccion, hemos querido revisar el papel que juegan varias de estas moleculas, las cuales pueden ser futuras dianas terapeuticas para tratar ciertos desordenes a nivel del LUT.
Purification and physical characterization of nucleic acid helix-unwinding proteins from calf thymus. (1976)

We have devised a general protein fractionation procedure which selects for eukaryotic DNA-binding proteins, some of which resemble DNA-unwinding proteins from prokaryotes. Proteins were selected which (a) pass through a native DNA-cellulose column, (b) bind to a denatured DNA-cellulose column, and (c) remain bound to the latter column during a rinse with a dilute solution of the sodium salt of the polyanion dextran sulfate. When this fractionation was applied to the soluble proteins of calf thymus, three major protein species were recovered. The predominant one has an apparent molecular weight of about 24,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis, is isoelectric near neutrality, and elutes as a monomer from denatured DNA-cellulose at moderate NaCl concentrations. This protein, designated calf-unwinding protein 1 (UPl), has been purified to homogeneity. However, isoelectric focusing reveals four or five subspecies (apparently separated by single-charge differences) which differ appreciably in their affinities for DNA.
Mobile Learning Applied Research Based on 3G Technology (2009)

China has entered the 3G era, this paper introduces the concept and function of 3G technology, analysis the characteristics of mobile learning. 3G technology has rich characteristics, which can be used for M-learning. When the 3G technology are applied in mobile learning, mobile learning will have new identities.
Line Of Sight Stabilization Using Image Motion Compensation (1989)

Image motion compensation (IMC) can be used to augment conventional line-of-sight (LOS) stabilization systems to improve stabilization performance. The tradeoffs involved in deciding when to use IMC and the expected performance improvements are reviewed. Several IMC concepts are outlined including the special case of a gimbaled optical element with a one-to-one scale factor between mechanical and image motion. The advantage of this IMC stabilization approach over other IMC techniques is that performance is not limited by the bandwidth of the sensor or actuator. Performance, however, is limited by optical scale factor accuracies. Precision measurement of the gimbal motion is not required to achieve LOS stabilization. The "restored mass stabilization" approach offers performance improvements without the high cost of precision inertial components.
Backward quasi-phase-matched second-harmonic generation in submicrometer periodically poled flux-grown KTiOPO4 (2005)

A 1mm thick flux-grown KTiOPO4 sample was poled with a 720nm domain period by employing deep-UV laser lithography, chemical patterning, and electric field poling. An atomic force microscope was used to characterize the periodic domain structure. The sample was used to demonstrate sixth and seventh order quasi-phase-matched backward second-harmonic generation.
Computer forensic timeline visualization tool (2009)

Computer Forensics is mainly about investigating crime where computers have been involved. There are many tools available to aid the investigator with this task. We have created a prototype of a new type of tool called CyberForensic TimeLab where all evidence is indexed by their time variables and plotted on a timeline. We believed that this way of visualizing the evidence allows the investigators to find coherent evidence faster and more intuitively. We have performed a user test where a group of people has evaluated our prototype tool against a modern commercial computer forensic tool and the results of this preliminary test are very promising. The results show that users completed the task in shorter time, with greater accuracy and with less errors using CyberForensic TimeLab. The subjects also experienced that the prototype were more intuitive to use and that it allowed them to easier locate evidence that was coherent in time.
Unprecedented Rearrangement of Molybdenum(VI) Oxide to (μ<sub>2</sub>‐Oxido)‐bis[dioxidomolybdenum(VI)] Hexamolybdate. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494) (2018)

The data presented here highlight the JAK1 selectivity of upadacinitinib and supports its use as an effective therapy for the treatment of RA with the potential for an improved benefit:risk profile.
High Fidelity Semantic Shape Completion for Point Clouds Using Latent Optimization (2019)

Semantic shape completion is a challenging problem in 3D computer vision where the task is to generate a complete 3D shape using a partial 3D shape as input. We propose a learning-based approach to complete incomplete 3D shapes through generative modeling and latent manifold optimization. Our algorithm works directly on point clouds. We use an autoencoder and a GAN to learn a distribution of embeddings for point clouds of object classes. An input point cloud with missing regions is first encoded to a feature vector. The representations learnt by the GAN are then used to find the best latent vector on the manifold using a combined optimization that finds a vector in the manifold of plausible vectors that is close to the original input (both in the feature space and the output space of the decoder). Experiments show that our algorithm is capable of successfully reconstructing point clouds with large missing regions with very high fidelity without having to rely on exemplar based database retrieval.
Advanced simulation techniques for thick photoresist lithography (1997)

A method has been developed that allows accurate simulation of pattern profiles in photoresist in excess of 10 micrometer thick. The method uses the DEPICT<SUP>R</SUP> photolithography simulator to model i-line exposure, bake and development of Shipley SJR<SUP>R</SUP>5740 thick film photoresists with an Ultratech 2244i Wafer Stepper<SUP>R</SUP>. Kim model inputs were estimated from a family of development rate curves obtained by processing wafers with a range of expose energies for logarithmically increasing develop times and measuring thickness change as the develop process occurred. These results were compared with dissolution results obtained using a laser-based dissolution rate monitor. Uncertainties in the measured photoresist absorbence, photosensitivity and refractive index coefficients were estimated and their influence on the simulated results were considered. An optimization procedure and algorithm that allows quantitative comparison of experimental and simulated photoresist profiles is presented. Simulated photoresist profiles were compared with patterns obtained from processed wafers. As a further test of the models, pattern profiles were simulated for 2 micrometer spaces in 10 micrometer thick photoresist through focus. Experimental and simulated pattern profiles from a range of exposure doses were also compared.
Trajectory generation for two robots cooperating to perform a task (2002)

This paper formulates an algorithm for trajectory generation for two robots cooperating to perform an assembly task. Treating the two robots as a single redundant system, this paper derives two Jacobian matrices which relate the joint rates of the entire system to the relative motion of the grippers with respect to one another. The main advantage of this method over previous methods is that operations may be described in the coordinates of the assembly rather than in world coordinates. To join parts using this algorithm, the desired relative position is specified and the algorithm automatically determines where the robots perform the assembly. In the process of generating the trajectory, the dexterity of the highly redundant dual-robot system is taken advantage of to satisfy a variety of secondary constraints. Secondary constraints may include obstacle and joint limit avoidance and constraints to satisfy certain absolute position and orientation goals. The algorithm typically involves two phases. First the parts to be assembled are brought from an arbitrary initial configuration to an approach configuration. This phase uses a newly derived relative distance Jacobian formulation which inherently avoids collisions. Then, a more traditional Jacobian formulation is used to join the parts.
Single-cell transcriptional dynamics of flavivirus infection (2018)

Dengue and Zika viral infections affect millions of people annually and can be complicated by hemorrhage and shock or neurological manifestations, respectively. However, a thorough understanding of the host response to these viruses is lacking, partly because conventional approaches ignore heterogeneity in virus abundance across cells. We present viscRNA-Seq (virus-inclusive single cell RNA-Seq), an approach to probe the host transcriptome together with intracellular viral RNA at the single cell level. We applied viscRNA-Seq to monitor dengue and Zika virus infection in cultured cells and discovered extreme heterogeneity in virus abundance. We exploited this variation to identify host factors that show complex dynamics and a high degree of specificity for either virus, including proteins involved in the endoplasmic reticulum translocon, signal peptide processing, and membrane trafficking. We validated the viscRNA-Seq hits and discovered novel proviral and antiviral factors. viscRNA-Seq is a powerful approach to assess the genome-wide virus-host dynamics at single cell level.
Capillary Leukocytes, Microaggregates, and the Response to Hypoxemia in the Microcirculation of Coronavirus Disease 2019 Patients (2021)

The response of the microcirculation to coronavirus disease 2019-induced hypoxemia seems to be to increase its oxygen-extraction capacity by increasing RBC availability. Inflammation and hypercoagulation are apparent in the microcirculation by increased numbers of leukocytes and RBC microaggregates.
Adenoids provide a microenvironment for the generation of CD4+, CD45RO+, L-selectin-, CXCR4+, CCR5+ T lymphocytes, a lymphocyte phenotype found in the middle ear effusion (2000)

Adenoidectomy in children with otitis media with effusion reduces inflammation in the middle ear by an unknown mechanism. Potentially, the adenoids of these children may serve as a site for the differentiation of lymphocytes, which after entering blood circulation eventually extravasate in the middle ear mucosa and thereby contribute to excessive inflammation. During lymphocyte extravasation various adhesion molecules and chemokines play a crucial role. To evaluate possible connections between the adenoids and middle ear inflammation, the expression of the chemokine receptors CXCR4 and CCR5 and the lymphocyte homing receptor L-selectin were analyzed in adenoidal and middle ear lymphocytes. It was found that most CD4(+) T lymphocytes in the middle ear effusion express the memory phenotype marker CD45RO and the chemokine receptors CXCR4 and CCR5, but are negative for the lymphocyte homing receptor L-selectin. This cell phenotype was rare in peripheral blood but was found much more frequently in the adenoids. The results suggest that the adenoids provide a microenvironment for the generation for CD4(+), CD45RO(+), L-selectin(-), CXCR4(+) and CCR5(+) T lymphocytes. Further, these cells may include cells that have the capacity to home to the middle ear mucosa. As the adenoidal CD4(+) memory phenotype CD45RO(+) T cells expressed the activation antigen CD69 and included cells expressing the HIV co-receptors CXCR4 and CCR5 at a high level, they may be permissive for HIV infection.
Realization of distributed remote laboratory and remote debug software for embedded system (2008)

Abstract:- Remote laboratories are becoming widely accepted in universities for providing distance education and for augmenting traditional laboratories. In this paper, A remote laboratory for embedded system is presented, where students at remote sites can perform actual experiments using actual hardware equipment and tools concurrently. Distributed architecture is presented using Web Services technique to share laboratories resource for multi-user. A design of ARM debugging interface based on JTAG is given. This debugging interface has been used for remote debugging to build embedded system remote laboratory. A Integrated learning environment for remote experimentation for embedded system is provided for convenient learning by students self.