gebhart/patrepeval huggingface dataset:
Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology (2017)

Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could be harmful to the human body and the environment. Hence, we propose the use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol. A dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement, stability in solution and cream dosage forms. We have also developed a high performance liquid chromatography method to measure the resveratrol within the final product. PAMAM dendrimers increased the solubility and stability of resveratrol in water and semisolid dosage forms. Therefore, this product would be water based 'green' formulation devoid of harsh organic solvents and oils and can be safely applied to the skin. Additionally, we have shown that the dendrimer helped to increase overall RSV loading and skin penetration of resveratrol. The dendrimer-RSV formulation was successfully scaled up towards commercialization. Dendrimer with RSV has led to an innovation in anti-aging cream and solutions that could be commercially marketed. Dendrimer-RSV complex could also be added to other product forms for additional purposes and applications.
Oxidative Addition of RCO<sub>2</sub>H and HX to Chiral Diphosphine Complexes of Iridium(I):  Convenient Synthesis of Mononuclear Halo-Carboxylate Iridium(III) Complexes and Cationic Dinuclear Triply Halogen-Bridged Iridium(III) Complexes and Their Catalytic Performance in Asymmetric Hydrogenation of Cyclic Imines and 2-Phenylquinoline (2006)

Mononuclear iridium(III) complexes of general formula IrX(H)(O2CR)[(S)-binap] (2, R = CH3; 3, R = Ph; 4, R = C6H4CH3-p; a, X = Cl; b, X = Br; c, X = I) were prepared by one-pot reaction of [Ir(μ-X)(cod)]2 with 2 equiv of (S)-BINAP [=2,2‘-bis(diphenylphosphino)-1,1‘-binaphthyl] and an excess of the corresponding carboxylic acid in toluene. The structure of (S)-2−4 bearing an (S)-BINAP was confirmed to be OC-6−23-A (Λ-conformation) by X-ray analysis of (S)-4a−c. In this reaction, the iridium(I) complex {Ir(μ-Cl)[(S)-binap]}2 [(S)-5a] and pentacoordinated iridium(I) complexes IrX(cod)[(S)-binap] [(S)-7b, X = Br; (S)-7c, X = I] were generated prior to the oxidative addition of carboxylic acid. Cationic dinuclear iridium(III) complexes of general formula [{Ir(H)[(S)-binap]}2(μ-X)3]X [(S)-8: a, X = Cl; b, X = Br; c, X = I] were prepared, and their cationic bifacial octahedral dinuclear structure was characterized by spectral data and combustion analysis. The anionic portion of these complexes could be replaced by NaPF6, leading to the corresponding PF6 salts [{Ir(H)[(S)-binap]}2(μ-X)3]PF6 [(S)-8: d, X = Cl; e, X = Br; f, X = I]. Iodo-acetate complexes of p-TolBINAP (=2,2‘-bis(di-4-tolylphosphino)-1,1‘-binaphthyl) [(S)-9c] and SYNPHOS [=2,2‘,3,3‘-tetrahydro(5,5‘-bi-1,4-benzodioxin)-6,6‘-diyl]bis(diphenylphosphine)] [(S)-10c] were also prepared according to the method used for the BINAP complex (S)-2c and were characterized spectroscopically. Cationic dinuclear complexes of p-TolBINAP [(S)-11c] and SYNPHOS [(S)-12c] were also generated. Using these complexes, the effect of halide variation was studied by asymmetric hydrogenation of 2-phenylpyrrolidine (13) and 2-phenyl-4,5,6,7-tetrahydro-3H-azepine (15) along with 2-phenylquinoline (16), and the results indicated that iodide complexes were better catalyst precursors for catalytic activity than the corresponding chloride and bromide complexes, but were not superior in enantioselectivity.
Capacitive ultrasonic transducers with a new vibrating structrure (2004)

In this work an electrostatic micromachined ultrasonic transducer using a new vibrating structure is described. The basic idea is to use a single thin plate suspended by means of a regular grid of small diameter columns. We show that this structure is able to vibrate, all in phase. The new transducer shows many potential advantages over the typical electrostatic cMUT: better transmission efficiency and reception sensitivity because the inactive area used by the column constraints is about 30% less than that used by the rails of the cMUT cells; for the same reason also a better reflection coefficient is expected. Because the virtual micro-cells of the device are not separated from each other there is no need to operate one or more holes to evacuate the micro-cells as in the typical cMUT technology; this means a better spatial uniformity of the mechanical characteristics of the vibrating plate and, in turn, less spurious vibration modes and improved mechanical reliability.
Handheld Reflectance Acquisition of Paintings (2017)

Relightable photographs are alternatives to traditional photographs as they provide a richer viewing experience. However, the complex acquisition systems of existing techniques have restricted its usage to specialized setups. We introduce an easy-to-use and affordable solution for using smartphones to acquire the reflectance of paintings and similar almost-planar objects like tablets, engravings and textile. Our goal is to enable interactive relighting of such artifacts by everyone. In our approach, we nonuniformly sample the reflectance functions by moving the LED light of a smartphone, and simultaneously, tracking the position of the smartphone by using its camera. We then propose a compressive-sensing-based approach for reconstructing the light transport matrix from the nonuniformly sampled data. As shown with experiments, we accurately reconstruct the light transport matrix that can then be used to create relightable photographs.
All-optical half adder using sole mechanism of XGM in semiconductor optical amplifiers (2004)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. H. Kim, J. H. Kim, J. W. Choi, Y. T. Byun, Y. M. Jhon, S. Lee, D. H. Woo, and S. H. Kim, "All-optical half adder using sole mechanism of XGM in semiconductor optical amplifiers," in Nonlinear Optics: Materials, Fundamentals and Applications, Technical Digest (CD) (Optica Publishing Group, 2004), paper WD7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
α-1,4-Glucan lyase-producing endophyte of<i>Gracilariopsis</i>sp. (Rhodophyta) from China (2000)

Purification of α-1,4-glucan lyase from red algae and fungi has previously been reported. The α-glucan lyase converts α-glucans to 1,5- anhydro-d-fructose. In this study, an endophyte was detected between the algal cells of Gracilariopsis sp., but not penetrating the cell walls. Histological staining was consistent with the endophyte being fungal and immunohistochemistry revealed that it possessed an α-1,4-glucan lyase differing from that of the host. The endophyte α-glucan lyase was recognized by antisera against both fungal and red algal α-glucan lyases, whereas the α-glucan lyase found in the algal tissue was recognized only by the antisera against algal α-glucan lyase. The lyases occur independently in the host and in the endophyte, and were sometimes detected simultaneously. The endophyte was only observed in Gracilariopsis sp. collected in China; no endophyte could be detected in Gracilariopsis sp. from California or in Gracilaria chilensis.
A multiple sub-carrier selection (MSCS) diversity architecture with reduced receiver complexity for wireless OFDM applications (2005)

A simple multiple sub-carrier selection (MSCS) diversity combining receiver architecture for 802.11 OFDM wireless applications is proposed. This architecture can improve the system diversity performance with nearly the hardware simplicity of selection combining. A complex analog filter bank is inserted into antenna RF front end, which is also part of channel selection filter. By detecting the power level at each complex filter output, we can choose the optimum band from each antenna filter to maximize the receiver signal output. The added hardware complexity of the analog/RF receiver is minimal, and only a single A/D and DFT block are required.
A novel approach for multidimensional interpolation (1999)

We have developed an approach for effectively reducing the interpolation dimensions and thus the computational burden in a multidimensional interpolation (MDI) problem. More important, our approach can be used for interpolation task where other interpolation techniques may not be applicable. We illustrate this approach by using MDI problems that arise in medical imaging.
<title>Intraoperative spectroscopic-guided brain tumor resection: reduction of blood contamination effects on tissue optical spectra</title> (2001)

An optical spectroscopy-based system for intraoperative guidance of brain tumor resection is currently under development at Vanderbilt University and Vanderbilt University Medical Center. The effectiveness of brain tumor margin detection, especially the infiltrating type, using combined in vivo autofluorescence and diffuse reflectance spectroscopy was successfully demonstrated in a preliminary clinical trial (on a total of 26 brain tumor patients). In this trial, a two-step empirical discrimination algorithm based on autofluorescence and diffuse reflectance intensity at 460 nm and 625 nm yielded 100% sensitivity and 76% specificity in differentiating infiltrating tumor margins from normal brain tissues.
Graphic overlays in high-precision teleoperation: Current and future work at JPL (1989)

In high-precision teleoperation, high-resolution visual depth information may be critical, thus requiring vision system capabilities quite different from lower precision teleoperation vision systems. Several possible approaches to providing this depth information are available. Multiple-camera television systems, 3-D television systems, and 3-D video graphics systems all have advantages and disadvantages. Multiple camera TV systems provide depth information by providing several views of the workspace. In such systems, camera mobility is desirable. However, moving cameras can confuse the operator. Therefore, the operator must know at all times the location of each camera. Providing such information can be cumbersome and increase operator workload. Converged stereo TV cameras configured for high-depth precision can yield significant depth distortions, thus making many high-precision tasks extremely difficult, even for trained operators. Video graphic systems can provide depth informat...
Stimuli Responsive Ionogels for Sensing Applications—An Overview (2012)

This overview aims to summarize the existing potential of "Ionogels" as a platform to develop stimuli responsive materials. Ionogels are a class of materials that contain an Ionic Liquid (IL) confined within a polymer matrix. Recently defined as "a solid interconnected network spreading throughout a liquid phase", the ionogel therefore combines the properties of both its solid and liquid components. ILs are low melting salts that exist as liquids composed entirely of cations and anions at or around 100 °C. Important physical properties of these liquids such as viscosity, density, melting point and conductivity can be altered to suit a purpose by choice of the cation/anion. Here we provide an overview to highlight the literature thus far, detailing the encapsulation of IL and responsive materials within these polymeric structures. Exciting applications in the areas of optical and electrochemical sensing, solid state electrolytes and actuating materials shall be discussed.
A channel-hopping protocol for ad-hoc networks (2002)

Media access control (MAC) protocols for wireless networks may be based on collision-avoidance handshakes between sender and receiver. Those protocols proposed or implemented to date require either carrier sensing or the assignment of unique node codes in order to ensure that intended receivers hear data packets without interference from hidden sources. We present and analyze a new collision-avoidance MAC protocol that we call receiver-initiated channel-hopping with dual polling (RICH-DP). RICH-DP is the first MAC protocol based on a receiver-initiated collision-avoidance handshake that does not require carrier sensing or the assignment of unique codes to nodes in order to ensure collision-free reception of data at the intended receivers in the presence of hidden terminals. The correct avoidance of collisions under hidden terminals is verified. The throughput and delay characteristics of RICH-DP are studied analytically, and extensive simulations are presented to verify the analysis and to present a more accurate prediction of how RICH-DP would operate in realistic scenarios. RICH-DP is applicable to ad-hoc networks based on commercial off-the-shelf frequency hopping radios operating in unlicensed frequency bands.
An Acidic Ascorbate Oxidase Produced by <i>Acremonium</i> sp. HI-25 (1991)

Journal Article An Acidic Ascorbate Oxidase Produced by Acremonium sp. HI-25 Get access Sawao Murao, Sawao Murao Department of Applied Microbial Technology, Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Homare Itoh, Homare Itoh Department of Applied Microbial Technology, Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Shigeki Fukuyasu, Shigeki Fukuyasu Department of Applied Microbial Technology, Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuo Hirayama, Kazuo Hirayama Department of Applied Microbial Technology, Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Takashi Shin Takashi Shin Department of Applied Microbial Technology, Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 55, Issue 6, 1 June 1991, Pages 1693–1694, https://doi.org/10.1080/00021369.1991.10870817 Published: 01 June 1991 Article history Received: 14 December 1990 Published: 01 June 1991
Bend-induced loss for the higher-order spatial mode in a dual-mode fiber (1993)

Measured loss for the LP(11) mode in a dual-mode fiber subjected to a uniform bend shows a strong dependence on the orientation of the mode-field pattern relative to the plane of the fiber bend. Wavelength and bend-radius dependence of the loss indicates that operation within ~40 nm of cutoff is feasible in dispersion compensators based on dual-mode fibers operated in the LP(11) spatial mode near cutoff.
4-D Optical Coherence Tomography of a beating chicken embryo heart (2004)

We are developing Optical Coherence Tomography as a tool for studying developmental cardiology. Using a gated reconstruction technique, we have produced a 4-D representation of a beating stage 28 chicken embryo heart.
Engineering T cell receptors for potential therapeutic applications (48.28) (2007)

Abstract Using T cell receptors (TCRs) for potential therapeutic applications provides an opportunity to target an expanded array of antigens, compared to those now targeted with monoclonal antibodies. Relative to antibodies, TCRs typically exhibit reduced solubility and lower affinity, properties that hamper their production and efficacy. To improve these parameters, we have developed strategies using yeast display engineering. Several different TCRs were cloned as single chain (sc) TCRs and VαCα/VβCβ heterodimers, as each of these display scaffolds has unique advantages for engineering and potential applications. Display of scTCRs, unlike that of scFv fragments, required mutagenesis and selection. Analysis of a collection of mutants revealed distinct regions of the scTCR that require mutations to allow yeast surface display, as well as solubility of purified protein. Although the sc format has several potential advantages such as increased tissue penetration, mutagenesis and selection of displayed mutants can present a technical challenge. To overcome this obstacle, we have recently explored the role of the C domains in driving heterodimer association. In addition, we have developed mutagenic strategies to improve the association of engineered, full λετ γη α and β chains. Supported by grants from NIH.
<title>Proposed radiology image lossy compression standard</title> (1996)

Radiology uses large images and series of images that can consume large amounts of storage or of communication bandwidth in the utilization of those images. An update to the standard for compressing radiology images is being considered by the medical imaging compression standards committee. A standard for compression of radiology images is proposed for consideration. The proposed standard uses four basic techniques to achieve very high quality reconstructed images: (a) image decomposition into high frequency and low frequency elements, (b) lapped orthogonal discrete cosine transforms, (c) local quantization, and (d) Huffman encoding. Degenerate forms of the standard include the JPEG standard, already included in the DICOM medical image interchange standard. The proposed standard is a departure from the JPEG standard because of the low quality of the baseline JPEG lossy compression. At the same time, much of the hardware and software that have been used for JPEG compression are applicable to the proposed standard technique. A preprocessing step changes the format of the image to a form that can be processed using JPEG compression. A post-processing step after the JPEG restoration will restore the image. The proposed standard does not permit many techniques that have been used in the past. In particular, decomposition by the level of the significant bits is not permitted, the only transform permitted is the lapped orthogonal discrete cosine transform, the block size of the transform is limited to 8 by 8, and only Huffman coding is allowed. There are many variations that can be used in compression. This proposal allows some variations, but restricts many other variations in the interest of simplicity for the standard. The quality of the compression is very good. The extra complexity in the standard to allow more variations is not warranted.
A sketching interface for modeling the internal structures of 3D shapes (2007)

This paper presents a sketch-based modeling system for creating objects that have internal structures. The user input consists of hand-drawn sketches and the system automatically generates a volumetric model. The volumetric representation solves any self-intersection problems and enables the creation of models with a variety of topological structures, such as a torus or a hollow sphere. To specify internal structures, our system allows the user to cut the model temporarily and apply modeling operations to the exposed face. In addition, the user can draw multiple contours in the Create or Sweep stages. Our system also allows automatic rotation of the model so that the user does not need to perform frequent manual rotations. Our system is much simpler to implement than a surface-oriented system because no complicated mesh editing code is required. We observed that novice users could quickly create a variety of objects using our systém.
Design and Analysis of a Long-range Magnetic Actuated and Guided Endoscope for Uniport VATS (2022)

This paper presents a long-range magnetic actuated and guided endoscope for uniport video-assisted thoracic surgery (VATS). In VATS, the incision is quite narrow and part of the chest wall may be very thick. So, the magnetic endoscope system is required to produce sufficient attractive force at a considerable distance with a compact dimension. In this paper, a magnetic endoscope system is developed to meet the aforementioned clinical demands. In the system, both the internal and external units consist of two cylindrical magnets at both ends and a semi-cylindrical magnet in the middle. Coupled with the magnetic field from the external unit, the internal endoscope can achieve anchoring, tilting, panning, and translating to provide the desired view for the surgeon. The rotation of the endoscope is dynamically modeled by combining magnetic theory and coordinate transformation. The prototype is made with a boundary box of 10×14×56 mm, which can be inserted through the narrow incision in VATS. In the experiment, the developed models of anchoring, tilting, and panning were verified. The magnet configuration in the system can achieve a static anchoring distance of 95 mm and exhibits enhancement in attractive force compared with other designs.
Use of radars to monitor stream discharge by noncontact methods (2006)

Conventional measurements of river flows are costly, time‐consuming, and frequently dangerous. This report evaluates the use of a continuous wave microwave radar, a monostatic UHF Doppler radar, a pulsed Doppler microwave radar, and a ground‐penetrating radar to measure river flows continuously over long periods and without touching the water with any instruments. The experiments duplicate the flow records from conventional stream gauging stations on the San Joaquin River in California and the Cowlitz River in Washington. The purpose of the experiments was to directly measure the parameters necessary to compute flow: surface velocity (converted to mean velocity) and cross‐sectional area, thereby avoiding the uncertainty, complexity, and cost of maintaining rating curves. River channel cross sections were measured by ground‐penetrating radar suspended above the river. River surface water velocity was obtained by Bragg scattering of microwave and UHF Doppler radars, and the surface velocity data were converted to mean velocity on the basis of detailed velocity profiles measured by current meters and hydroacoustic instruments. Experiments using these radars to acquire a continuous record of flow were conducted for 4 weeks on the San Joaquin River and for 16 weeks on the Cowlitz River. At the San Joaquin River the radar noncontact measurements produced discharges more than 20% higher than the other independent measurements in the early part of the experiment. After the first 3 days, the noncontact radar discharge measurements were within 5% of the rating values. On the Cowlitz River at Castle Rock, correlation coefficients between the USGS stream gauging station rating curve discharge and discharge computed from three different Doppler radar systems and GPR data over the 16 week experiment were 0.883, 0.969, and 0.992. Noncontact radar results were within a few percent of discharge values obtained by gauging station, current meter, and hydroacoustic methods. Time series of surface velocity obtained by different radars in the Cowlitz River experiment also show small‐amplitude pulsations not found in stage records that reflect tidal energy at the gauging station. Noncontact discharge measurements made during a flood on 30 January 2004 agreed with the rated discharge to within 5%. Measurement at both field sites confirm that lognormal velocity profiles exist for a wide range of flows in these rivers, and mean velocity is approximately 0.85 times measured surface velocity. Noncontact methods of flow measurement appear to (1) be as accurate as conventional methods, (2) obtain data when standard contact methods are dangerous or cannot be obtained, and (3) provide insight into flow dynamics not available from detailed stage records alone.