gebhart/patrepeval huggingface dataset:
Method and apparatus for symptom diagnosis by monitoring vibration of shaft of rotary machine (1985)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Nobuo Kurihara, Yasuo Morooka, Mitsuyo Nishikawa, Kiyoshi Miura, Yoshitoshi Nagahashi; Method and apparatus for symptom diagnosis by monitoring vibration of shaft of rotary machine. J. Acoust. Soc. Am. 1 February 1985; 77 (2): 777. https://doi.org/10.1121/1.392325 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Surface shape memory substrates for active cell culture (2011)

Shape memory polymer (SMP) substrates compatible with cell culture are presented that undergo programmed changes in surface topography on command to direct cell behavior. SMPs are a class of active materials that can be programmed to transition from a stable temporary shape to a permanent shape by a triggering mechanism, such as heat. Here, an SMP surface topography was programmed to transition from parallel micron-scale grooves to a flat surface. C3H/10T1/2 cells were allowed to adhere and spread on the temporary topography at 30°C. Topographic transition was then triggered by transfer to 37°C. Changes in substrate topography were found to direct cell behavior, as assessed by analysis of cell alignment, while high cell viability was maintained. This first example of active cell culture substrates should have great potential in the design of unique approaches for advanced investigation of mechanotransduction and cell biomechanical function and softmatter physics.
Endogenous Cardiac Stem Cells (2007)

In recent years, the evidence of myocardial regeneration in animal models as well as in humans has produced a paradigm shift in scientific opinion: cardiomyocytes can be generated ex novo in the adult heart. The origin of these dividing myocytes is still the subject of scientific debate. In fact, following the first observations of chimerism in transplanted heart and myocyte growth in cardiac hypertrophy and failure, studies of different groups pointed to the existence of local primitive stem (or progenitor) cells, which are able to proliferate and differentiate during the entire cardiac cell lineage.This chapter will focus on those resident cardiac cells claimed to be local sources of myocardial regeneration (endogenous cardiac stem cells). Different isolation procedures, characterization, and potential clinical application will be discussed.
ChemInform Abstract: 7‐Heteroaryl‐1,2,3,5‐tetrahydroimidazo(2,1‐b)quinazolin‐2(1H)‐one Derivatives with Cardiac Stimulant Activity. (1990)

Abstract Palladium‐catalyzed cross coupling of the pyridylzinc chloride (III), obtained from 3‐bromo‐2,6‐dimethylpyridine (I), magnesium, and zinc dichloride (II), with the 7‐iodotetrahydroimidazo(2,1‐b)quinazolinones (IV) produces the title compounds (V).
COMBINED IMMUNOSUPPRESSION OF MYCOPHENOLATE MOFETIL AND FK506 FOR MYOBLAST TRANSPLANTATION IN mdx MICE1 (2001)

The diminution of graft success when combining FK506 and MMF by the time of myoblast transplantation could be attributed to the inhibition of myoblast fusion by MMF. The use of MMF and FK506 after the establishment of the graft did not reduce graft success, however, this combination was not effective at controlling long-term immune rejection in comparison with the optimal dose of FK506 alone.
A Zinc-Dependent Mechanism Regulates Meiotic Progression in Mammalian Oocytes1 (2012)

Precise coordination of meiotic progression is a critical determinant of an egg's capacity to be fertilized successfully, and zinc has emerged as a key regulatory element in this process. An early manifestation of a regulatory role for this transition metal is the significant increase in total intracellular zinc. This accumulation is essential for meiotic progression beyond telophase I and the establishment of meiotic arrest at metaphase II. The subsequent developmental event, fertilization, induces a rapid expulsion of labile zinc that is a hallmark event in meiotic resumption. In the present study, we show that the zinc fluxes work, in part, by altering the activity of the cytostatic factor (CSF), the cellular activity required for the establishment and maintenance of metaphase II arrest in the mature, unfertilized egg. We propose a model in which zinc exerts concentration-dependent regulation of meiosis through the CSF component EMI2, a zinc-binding protein. Together, the data support the conclusion that zinc itself, through its interaction with EMI2, is a central component of the CSF.
Factoring using 2n+2 qubits with Toffoli based modular multiplication (2017)

We describe an implementation of Shor’s quantum algorithm to factor n-bit integers using only 2n+2 qubits. In contrast to previous space-optimized implementations, ours features a purely Toffoli based modular multiplication circuit. The circuit depth and the overall gate count are in O(n 3 ) and O(n 3 log n), respectively. We thus achieve the same space and time costs as Takahashi et al. [1], while using a purely classical modular multiplication circuit. As a consequence, our approach evades most of the cost overheads originating from rotation synthesis and enables testing and localization of some faults in both, the logical level circuit and an actual quantum hardware implementation. Our new (in-place) constant-adder, which is used to construct the modular multiplication circuit, uses only dirty ancilla qubits and features a circuit size and depth in O(n log n) and O(n), respectively.
Node placement approaches for pipelines monitoring: simulation and experimental analysis (2019)

Monitoring oil, gas and water pipeline networks is a critical problem; its impact has serious consequences on the ecosystem. Placing sensors that monitor these pipelines is a challenging problem. Naturally, a linear topology is adopted which requires careful attention in placing sensors in order to minimise energy consumption, maximise network lifetime and ensure robustness against anomaly. In this work, we have studied two existing greedy node placement approaches via simulation and experimental analysis. First, we have validated experimentally the 31 power levels of CC2420 TelosB chipon and their corresponding transmission ranges. Having more power-level resolution provides more flexible power assignment, which yields less energy consumption and longer lifetime compared to traditional 8 power levels. Second, extensive simulation and real experiments have been conducted. The results demonstrate a considerable drop in power consumption, which can reach 73% and 23% extension in the network lifetime when all 31 power levels are adopted.
Magnetic Nanocomposite Cilia Tactile Sensor (2015)

A multifunctional biomimetic nanocomposite tactile sensor is developed that can detect shear and vertical forces, feel texture, and measure flow with extremely low power consumption. The sensor's high performance is maintained within a wide operating range that can be easily adjusted. The concept works on rigid and flexible substrates and the sensors can be used in air or water without any modifications.
New prospects for noninvasive blood monitoring based on effect of RBC aggregation (2008)

Our analysis of spectral behavior of time-variant optical characteristics caused by RBC aggregation is applied to issues of non-invasive blood monitoring. Modulations of blood flow cause the change in geometry of RBC aggregates and corresponding variance of light scattering. This changes cause the variation of optical transmission, reflection, and polarization of outcoming light. The last can be translated back in absorption coefficients of various blood constituents, refractive index mismatch, etc. For instance, in case of long occlusion simultaneous measurements of both the azimuthal angle and the ellipticity of outcoming light can provide sufficient data to determine the blood glucose.
Preferential mammary carcinogenic effects of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐<i>b</i>]pyridine (PhIP) in human c‐Ha‐<i>ras</i> proto‐oncogene transgenic rats (2004)

In order to clarify the susceptibility of the Hras128 rat harboring copies of the human c-Ha-ras proto-oncogene to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), Hras128 rats were intragastically treated with 100 mg/kg PhIP 8 times (females) or 80 mg/kg PhIP 10 times (males) over a 9-week period, then sacrificed at weeks 12 and 30. Multiple mammary tumors of adenocarcinoma type were induced in all females, while 83% of treated males developed adenocarcinomas, sarcomas and transitional carcinosarcomas, as evidenced by casein and vimentin immunoreactivity. All tumors examined had mutations in the c-Ha-ras transgene, while the endogenous rat c-Ha-ras gene was intact. Our results indicate that 1) Hras128 rats of both sexes are preferentially susceptible to mammary carcinogenesis with PhIP; 2) activation of the transgene, but not the endogenous c-Ha-ras gene, may be important in this regard; 3) the variety of tumor types evident in male rats indicates that immature mammary gland cells of the terminal end buds may be a target of PhIP; 4) although the transgene is expressed in all organs, susceptibility to PhIP is limited to mammary glands.
Iterative epigenomic analyses in the same single cell (2021)

Gene expression in individual cells is epigenetically regulated by DNA modifications, histone modifications, transcription factors, and other DNA-binding proteins. It has been shown that multiple histone modifications can predict gene expression and reflect future responses of bulk cells to extracellular cues. However, the predictive ability of epigenomic analysis is still limited for mechanistic research at a single cell level. To overcome this limitation, it would be useful to acquire reliable signals from multiple epigenetic marks in the same single cell. Here, we propose a new approach and a new method for analysis of several components of the epigenome in the same single cell. The new method allows reanalysis of the same single cell. We found that reanalysis of the same single cell is feasible, provides confirmation of the epigenetic signals, and allows application of statistical analysis to identify reproduced reads using data sets generated only from the single cell. Reanalysis of the same single cell is also useful to acquire multiple epigenetic marks from the same single cells. The method can acquire at least five epigenetic marks: H3K27ac, H3K27me3, mediator complex subunit 1, a DNA modification, and a DNA-interacting protein. We can predict active signaling pathways in K562 single cells using the epigenetic data and confirm that the predicted results strongly correlate with actual active signaling pathways identified by RNA-seq results. These results suggest that the new method provides mechanistic insights for cellular phenotypes through multilayered epigenome analysis in the same single cells.
Trehalose Production by a Strain of<i>Micrococcus varians</i> (1995)

Journal Article Trehalose Production by a Strain of Micrococcus varians Get access Hideki Kizawa, Hideki Kizawa Integrated Technology Laboratories, Takeda Chemical Industries, 10 Wadai, Tsukuba-shi, Ibaraki 300-42, Japan Corresponding author. Present address: Discovery Research Laboratories I, Takeda Chemical Industries, 10 Wadai, Tsukuba-shi, Ibaraki 300–42, Japan. Search for other works by this author on: Oxford Academic Google Scholar Jun-ichi Miyazaki, Jun-ichi Miyazaki Integrated Technology Laboratories, Takeda Chemical Industries, 10 Wadai, Tsukuba-shi, Ibaraki 300-42, Japan Search for other works by this author on: Oxford Academic Google Scholar Akira Yokota, Akira Yokota Integrated Technology Laboratories, Takeda Chemical Industries, 10 Wadai, Tsukuba-shi, Ibaraki 300-42, JapanInstitute for Fermentation, Osaka, 2–17–85 Juso-honmachi, Yodogawa-ku, Osaka 532, Japan Search for other works by this author on: Oxford Academic Google Scholar Yukihiro Kanegae, Yukihiro Kanegae Integrated Technology Laboratories, Takeda Chemical Industries, 10 Wadai, Tsukuba-shi, Ibaraki 300-42, JapanTakasago Production Technology, Production Technology Department, Vitamin & Food Division, Takeda Chemical Industries, 1–5 Takasago-cho, Takasago-shi, Hyogo 676, Japan Search for other works by this author on: Oxford Academic Google Scholar Ken-ichiro Miyagawa, Ken-ichiro Miyagawa Integrated Technology Laboratories, Takeda Chemical Industries, 10 Wadai, Tsukuba-shi, Ibaraki 300-42, Japan Search for other works by this author on: Oxford Academic Google Scholar Yoshio Sugiyama Yoshio Sugiyama Integrated Technology Laboratories, Takeda Chemical Industries, 10 Wadai, Tsukuba-shi, Ibaraki 300-42, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 59, Issue 8, 1 January 1995, Pages 1522–1527, https://doi.org/10.1271/bbb.59.1522 Published: 01 January 1995 Article history Published: 01 January 1995 Received: 15 February 1995
Heterogeneous integration of silicon photonic devices and integrated circuits (2015)

Aurrion's heterogeneous integration platform enables simultaneous integration of active and passive photonic components on a silicon substrate. The platform provides photonic device library where each component is tailored to deliver maximum functionality for large scale photonic integrated circuits.
A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus (2017)

New strategies are needed to combat antibiotic resistance, especially against pathogens such as methicillin-resistant <i>Staphylococcus aureus</i> A tick antifreeze glycoprotein, IAFGP, possesses potent antibiofilm properties against a variety of clinical pathogens, including <i>S. aureus</i> Synergy between IAFGP, or a peptide (P1) representative of a repeat region of the protein, with different antibiotics was assessed <i>in vitro</i> Antibiotics that synergized with either IAFPG or P1 were further evaluated <i>in vivo</i> using vertebrate and invertebrate infection models. IAFGP readily enhanced the efficacy of antibiotics against <i>S. aureus</i> Synergy with daptomycin, an antibiotic used to treat methicillin-resistant <i>S. aureus</i>, was observed <i>in vitro</i> and <i>in vivo</i> using <i>iafgp</i>-transgenic mice and flies. Furthermore, synergy with ciprofloxacin or gentamicin, antibiotics not generally used to treat <i>S. aureus</i>, was also perceived. The combined effect of the antibiotic and IAFGP was associated with improved permeation of the antibiotic into the cell. Our results highlight that synergy of IAFGP with antibiotics traditionally used to treat this pathogen, and enhancement of the potency of antibiotics not commonly used against this microbe, can provide novel alternative therapeutic strategies to combat bacterial infections.
Spin-torque switching efficiency in CoFeB-MgO based tunnel junctions (2013)

It is convenient to define the spin-torque switching efficiency in nanostructured magnetic tunnel junctions as the ratio between the free-layers thermal activation barrier height ${E}_{b}$ and the threshold switching current ${I}_{c0}$. Recent device exploration has led to occasional observations of spin-torque induced magnetic switching efficiency in magnetic tunnel junctions that exceeds the macrospin limit by a factor of 2--10. In this paper we examine the possible origins for such enhancement, and materials properties that may allow the full realization of such enhancements.
Efficient Inner-product Algorithm for Stabilizer States (2012)

Large-scale quantum computation is likely to require massive quantum error correction (QEC). QEC codes and circuits are described via the stabilizer formalism, which represents stabilizer states by keeping track of the operators that preserve them. Such states are obtained by stabilizer circuits (consisting of CNOT, Hadamard and Phase only) and can be represented compactly on conventional computers using Omega(n^2) bits, where n is the number of qubits. Although techniques for the efficient simulation of stabilizer circuits have been studied extensively, techniques for efficient manipulation of stabilizer states are not currently available. To this end, we design new algorithms for: (i) obtaining canonical generators for stabilizer states, (ii) obtaining canonical stabilizer circuits, and (iii) computing the inner product between stabilizer states. Our inner-product algorithm takes O(n^3) time in general, but observes quadratic behavior for many practical instances relevant to QECC (e.g., GHZ states). We prove that each n-qubit stabilizer state has exactly 4(2^n - 1) nearest-neighbor stabilizer states, and verify this claim experimentally using our algorithms. We design techniques for representing arbitrary quantum states using stabilizer frames and generalize our algorithms to compute the inner product between two such frames.
Fourier Transform-Based Modified Phasor Estimation Method Immune to the Effect of the DC Offsets (2009)

This paper proposes a Fourier transform-based modified phasor estimation method to eliminate the adverse influence of the exponentially decaying dc offsets when discrete Fourier transform (DFT) is used to calculate the phasor of the fundamental frequency component in a relaying signal. By subtracting the result of odd-sample-set DFT from the result of even-sample-set DFT, the information of dc offsets can be obtained. Two dc offsets in a secondary relaying signal are treated as one dc offset which is piecewise approximated in one cycle data window. The effect of the dc offsets can be eliminated by the approximated dc offset. The performance of the proposed algorithm is evaluated by using computer-simulated signals and Electromagnetic Transients Program-generated signals. The algorithm is also tested on a hardware board with TMS320C32 microprocessor. The evaluation results indicate that the proposed algorithm can estimate the accurate phasor of the fundamental frequency component regardless of not only the primary decaying dc offset but also the secondary decaying dc offset caused by CT circuit itself including its burden.
The Electrochemical Oxidation of Silicon and Formation of Porous Silicon in Acetonitrile (1994)

The photoelectrochemical oxidation and dissolution of silicon has been investigated in the absence of water and oxygen. The etch rate and photocurrent for n‐Si in an anhydrous, solution were directly proportional to light intensity. Four electrons were transferred per silicon oxidized, with a quantum yield greater than 3.3 due to electron injection. The anodic dissolution of p‐Si, as Si(IV) without gas at up to 1.4 A/cm2, yielded a novel porous structure which exhibited electroluminescence and photoluminescence. Noninterconnected pores were formed perpendicular to the surface, and were 1 to 2 μm in diameter, spaced 2 to 3 μm apart, and over 225 μm long. The profusion of micropores and quantum size structures (<100 nm), normally found with porous silicon produced in aqueous electrolytes, were not detected by transmission electron microscopy and scanning electron microscopy analyses. A mechanism for the oxidative dissolution of silicon is proposed. The luminescence was a function of the pore length and appears to be related to the presence of a dihydride surface. The absence of water and oxygen shows that siloxene is not involved in the luminescence. The inability to detect obvious quantum structures, and the insensitivity of the luminescence to porous shapes tends to support the alloy or surface passivation mechanism of luminescence.
/sup 3/He--/sup 4/He dilution refrigerator (1979)

A /sup 3/He--/sup 4/He dilution refrigerator is provided with two interconnected mixing chambers arranged at different levels. One end of a superleak opens into concentrated /sup 3/He contained in the upper mixing chamber, while the other end opens into a portion of the apparatus containing dilute /sup 3/He for the supply of superfluid /sup 4/He, via the superleak, to the upper mixing chamber under the influence of the osmotic differential pressure prevailing across the superleak.
Synthesis and pharmacology of 8-amino-3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-cis-6,11-dimethyl-2,6-methano-3-benzazocine and related compounds (1980)

The little compound 1a has been prepared and was found to be a strong, orally active agonist with narcotic--antagonist properties. 1a was prepared by two independent routes: (1) nitration of volazocine and subsequent reduction and (b) a sequence involving dissolving metal reduction of cyclazocine methyl ether, followed by oximination and Semmler--Wolff rearrangement. Several analogues were prepared and tested.
Extreme ultraviolet carrier-frequency shearing interferometry of a lithographic four-mirror optical system (2000)

The phase-shifting point diffraction interferometer (PS/PDI) has recently been developed to address the problem of at-wavelength metrology of extreme ultraviolet (EUV) optical systems. Although extremely accurate, the fact that the PS/PDI is limited to use with coherent EUV sources, such as undulator radiation, is a drawback for its widespread use. An alternative to the PS/PDI, with relaxed coherence requirements, is lateral shearing interferometry (LSI). Here we describe various LSI implementations and demonstrate the use of a cross-grating, carrier-frequency configuration to characterize a large-field 4×-reduction EUV lithography optic. The results obtained are directly compared with PS/PDI measurements.
Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations (2017)

Accurate detection and identification of low frequency mutations can be problematic when assessing residual disease after therapy, screening for emerging resistance mutations during therapy, or when patients have few circulating tumor cells. Wild-type blocking PCR followed by sequencing analysis offers high sensitivity, flexibility, and simplicity as a methodology for detecting these low frequency mutations. By adding a custom designed locked nucleic acid oligonucleotide to a new or previously established conventional PCR based sequencing assay, sensitivities of approximately 1 mutant allele in a background of 1,000 WT alleles can be achieved (1:1,000). Sequencing artifacts associated with deamination events commonly found in formalin fixed paraffin embedded tissues can be partially remedied by the use of uracil DNA glycosylase during extraction steps. The optimized protocol here is specific for detecting MYD88 mutation, but can serve as a template to design any WTB-PCR assay. Advantages of the WTB-PCR assay over other commonly utilized assays for the detection of low frequency mutations including allele specific PCR and real-time quantitative PCR include fewer occurrences of false positives, greater flexibility and ease of implementation, and the ability to detect both known and unknown mutations.