gebhart/patrepeval huggingface dataset:
Beneficial Effect of Nifedipine and Moxonidine on Glomerulosclerosis in Spontaneously Hypertensive Rats (1992)

The effect of calcium channel blockers on the development of glomerulosclerosis and progression of renal failure in different models of renal injury is still controversial. We compared the effects of blood pressure lowering with high doses of nifedipine (27 mg/kg body weight/day) and with the sympatholytic agent moxonidine (8 mg/kg body weight/day) in 6-month-old male spontaneously hypertensive rats (SHRsp). As controls we studied untreated hypertensive SHRsp and normotensive Wisfar-Kyoto rats (WKY). After 3 months of treatment, left ventricular (LV) weight and systolic blood pressure (tail plethysmography) were lower in both treated groups (144 ± 21.4 mm Hg and 144 ± 13.5 mm Hg ν 193 ± 38.6 mm Hg in untreated SHRsp); but remained higher than in WKY (116 ± 16.0 mm Hg). Stereological analysis of perfusion fixed kidneys showed an unchanged total volume of cortex and medulla, but a higher mean glomerular volume in nifedipine treated SHRsp. The glomerulosclerosis index was similarly reduced by both antihypertensive agents (92.8 ± 68.1 in untreated SHRsp ν 27.2 ± 12.9 and 18.2 ± 9.8 in the two treatment groups, respectively). This was accompanied by a similar reduction of total cortical arterial wall volume (from 36.3 ± 16.5 mm3 to 18.9 ± 2.53 and 15.3 ± 2.53 mm3, respectively) and by reduction of tubular atrophy or interstitial fibrosis, respectively. In this model nifedipine lowered blood pressure and inhibited development of glomerulosclerosis to the same extent as a sympatholytic agent. This was accompanied by increased glomerular volume and filtration area in nifedipine treated animals. Am J Hypertens 1992;5:437–443
Physical load during work and leisure time as risk factors for back pain (1999)

This systematic review assessed aspects of physical load during work and leisure time as risk factors for back pain. Several reviews on this topic are available, but this one is based on a strict systematic approach to identify and summarize the evidence, comparable with that applied in the clinical literature on the efficacy of intervention for back pain. A computerized bibliographical search was made of several data bases for studies with a cohort or case-referent design. Cross-sectional studies were excluded. A rating system was used to assess the strength of the evidence, based on the methodological quality of 28 cohort and 3 case-referent studies and the consistency of the findings. Strong evidence exists for manual materials handling, bending and twisting, and whole-body vibration as risk factors for back pain. The evidence was moderate for patient handling and heavy physical work, and no evidence was found for standing or walking, sitting, sports, and total leisure-time physical activity.
Case 34-2004 (2004)

A 45-year-old man had right flank pain associated with hematuria. Computed tomographic scanning without enhancement disclosed a nonobstructing stone in the right kidney. After a second episode 11 months later, the stone was still present, and there was new dilatation of the right renal pelvis. The physicians discuss how this patient was evaluated and treated.
Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities (2020)

The prognostic and therapeutic relevance of molecular subtypes for the most aggressive isocitrate dehydrogenase 1/2 (IDH) wild-type glioblastoma (GBM) is currently limited due to high molecular heterogeneity of the tumors that impedes patient stratification. Here, we describe a distinct binary classification of IDH wild-type GBM tumors derived from a quantitative proteomic analysis of 39 IDH wild-type GBMs as well as IDH mutant and low-grade glioma controls. Specifically, GBM proteomic cluster 1 (GPC1) tumors exhibit Warburg-like features, neural stem-cell markers, immune checkpoint ligands, and a poor prognostic biomarker, FKBP prolyl isomerase 9 (FKBP9). Meanwhile, GPC2 tumors show elevated oxidative phosphorylation-related proteins, differentiated oligodendrocyte and astrocyte markers, and a favorable prognostic biomarker, phosphoglycerate dehydrogenase (PHGDH). Integrating these proteomic features with the pharmacological profiles of matched patient-derived cells (PDCs) reveals that the mTORC1/2 dual inhibitor AZD2014 is cytotoxic to the poor prognostic PDCs. Our analyses will guide GBM prognosis and precision treatment strategies.
Bi-dimensional position detection using TDOA estimation through cross correlation of the acoustic signals. Part 1: Theoretical background (2009)

The paper deals with a positioning acoustic method that uses the time difference of arrival estimation through the cross-correlation techniques. The method will be applied for the determination of the position of the impact points of the air-dropped bombs. Firstly, the acoustic methods for position detection are presented, and the methodology for air dropped bombs impact points position estimation is chosen. The proposed method and the positioning system architecture are described.
Key technologies of junction boxes for Chinese experimental ocean observatory networks (2015)

Ocean observatory networks have been investigated and developed and are receiving considerable attention in the 21st century. As intermediate processing nodes, junction boxes (JBs) are essential sections of ocean observatory networks. This paper explored the key technologies of JBs for Chinese experimental seafloor observatory networks, including industrial control, Ethernet communication, and time synchronization technologies. Specific functional verifications of each section were conducted in the laboratory prior to sea trials. The JBs were packaged in a frame and were deployed in the East and South China Sea. Results of the laboratory and sea trial experiments demonstrated that the examined technologies were effective and could provide valid guarantee to the long operation of the JBs.
HiNextApp: A Context-Aware and Adaptive Framework for App Prediction in Mobile Systems (2017)

A variety of applications (App) installed on mobile systems such as smartphones enrich our lives, but make it more difficult to the system management. For example, finding the specific Apps becomes more inconvenient due to more Apps installed on smartphones, and App response time could become longer because of the gap between more, larger Apps and limited memory capacity. Recent work has proposed several methods of predicting next used Apps (here in after appprediction) to solve the issues, but faces the problems of the low prediction accuracy and high training costs. Especially, applying app-prediction to memory management (such as LMK) and App prelaunching has high requirements for the prediction accuracy and training costs. In this paper, we propose an app-prediction framework, named HiNextApp, to improve the app-prediction accuracy and reduce training costs in mobile systems. HiNextApp is based on contextual information, and can adjust the size of prediction periods adaptively. The framework mainly consists of two parts: non-uniform bayes model and an elastic algorithm. The experimental results show that HiNextApp can effectively improve the prediction accuracy and reduce training times. Besides, compared with traditional bayes model, the overhead of our framework is relatively low.
Body Mass Index, Serum Sex Hormones, and Breast Cancer Risk in Postmenopausal Women (2003)

The results are compatible with the hypothesis that the increase in breast cancer risk with increasing BMI among postmenopausal women is largely the result of the associated increase in estrogens, particularly bioavailable estradiol.
Interaction and recognition challenges in interpreting children's touch and gesture input on mobile devices (2012)

As mobile devices like the iPad and iPhone become increasingly commonplace, touchscreen interactions are quickly overtaking other interaction methods in terms of frequency and experience for many users. However, most of these devices have been designed for the general, typical user. Trends indicate that children are using these devices (either their parents' or their own) for entertainment or learning activities. Previous work has found key differences in how children use touch and surface gesture interaction modalities vs. adults. In this paper, we specifically examine the impact of these differences in terms of automatically and reliably understanding what kids meant to do. We present a study of children and adults performing touch and surface gesture interaction tasks on mobile devices. We identify challenges related to (a) intentional and unintentional touches outside of onscreen targets and (b) recognition of drawn gestures, that both indicate a need to design tailored interaction for children to accommodate and overcome these challenges.
26 amino acids of an extracellular domain of the Na,K-ATPase alpha-subunit are sufficient for assembly with the Na,K-ATPase beta-subunit. (1994)

Chimeric cDNAs encoding a sarcoplasmic/endoplasmic reticulum Ca-ATPase (SERCA1) and regions of the Na,K-ATPase alpha-subunit were constructed to seek the minimal region of the alpha-subunit sufficient for assembly with the Na,K-ATPase beta-subunit. cDNAs encoding a chimera and the chicken beta-subunit were coexpressed in mammalian cells and assembly was assayed by immune precipitation of the chimeric subunit with a monoclonal antibody to the chicken beta-subunit. A chimera containing 26 amino acyl residues of the Na,K-ATPase alpha 1-subunit (NDVEDSYGQQWTFEQRKIVEFTCHTA) (Asn894 to Ala919) that replaced the corresponding avian SERCA1 Ca-ATPase amino acyl residues (Thr871 to Thr898) was able to assemble with the chicken beta-subunit. This alpha-subunit region is predicted to be extracellular, located between membrane-spanning domains 7 and 8 (H7-H8). Chimeras that assembled with full-length beta-subunit also assembled with a beta-subunit chimera that retained only the ectodomain of the chicken beta 1-subunit. These results suggest that the Na,K-ATPase alpha-subunit has the same topology in the membrane as the sarcoplasmic reticulum Ca-ATPase, probably with 10 membrane-spanning domains, and that the aminoacyl residues between membrane domains H7 and H8 are involved in assembly with the beta-subunit in the extracellular/lumenal space.
An Interpretable Model for Scene Graph Generation (2018)

We propose an efficient and interpretable scene graph generator. We consider three types of features: visual, spatial and semantic, and we use a late fusion strategy such that each feature's contribution can be explicitly investigated. We study the key factors about these features that have the most impact on the performance, and also visualize the learned visual features for relationships and investigate the efficacy of our model. We won the champion of the OpenImages Visual Relationship Detection Challenge on Kaggle, where we outperform the 2nd place by 5\% (20\% relatively). We believe an accurate scene graph generator is a fundamental stepping stone for higher-level vision-language tasks such as image captioning and visual QA, since it provides a semantic, structured comprehension of an image that is beyond pixels and objects.
Causal Inference and Causal Explanation with Background Knowledge (2013)

This paper presents correct algorithms for answering the following two questions; (i) Does there exist a causal explanation consistent with a set of background knowledge which explains all of the observed independence facts in a sample? (ii) Given that there is such a causal explanation what are the causal relationships common to every such causal explanation?
Total synthesis of (+/ − )-4-demethylenglerin A (2014)

Racemic 4-demethylenglerin A (1'), a simplified analog of the guaiane-type sesquiterpene englerin A (1), has been synthesized. The cyclic hydrocarbon core structure was built through modified Metz approach using epoxynitrile cyclization and direct Aldol reaction to prepare the precursor of RCM. The primary cytotoxicity test summarized that C4 methyl has marked impacts on the bioactivity.
End-to-End Deep Structured Models for Drawing Crosswalks (2020)

In this paper we address the problem of detecting crosswalks from LiDAR and camera imagery. Towards this goal, given multiple LiDAR sweeps and the corresponding imagery, we project both inputs onto the ground surface to produce a top down view of the scene. We then leverage convolutional neural networks to extract semantic cues about the location of the crosswalks. These are then used in combination with road centerlines from freely available maps (e.g., OpenStreetMaps) to solve a structured optimization problem which draws the final crosswalk boundaries. Our experiments over crosswalks in a large city area show that 96.6% automation can be achieved.
Literature Review: Materials with Negative Poisson's Ratios and Potential Applications to Aerospace and Defence (2006)

An auxetic material exhibits exceptional features, which are different from a conventional material. That is, the auxetic material gets fatter when it is stretched, or becomes smaller when it is compressed, because it has a negative Poisson's ratio. This report briefly reviews the latest advances in research work in auxetic materials, structural mechanisms, properties and application, particularly in aerospace and defense.
Analysis of multiple reflection effects in reflective measurements of electro-optic coefficients of poled polymers in multilayer structures (2006)

We present new closed-form expressions for analysis of Teng-Man measurements of the electro-optic coefficients of poled polymer thin films. These expressions account for multiple reflection effects using a rigorous analysis of the multilayered structure for varying angles of incidence. The analysis based on plane waves is applicable to both transparent and absorptive films and takes into account the properties of the transparent conducting electrode layer. Methods for fitting data are presented and the error introduced by ignoring the transparent conducting layer and multiple reflections is discussed.
Cantilever‐Free Scanning Probe Molecular Printing (2011)

25 and 30 years after the invention of AFM and STM, respectively, cantilever-free scanning probe lithography tools such as polymer pen lithography (see picture) mark an important development in the evolution of molecular printing. These simple, robust, and inexpensive approaches allow researchers to create nanoscale and microscale features of various organic and inorganic materials on surfaces in arbitrary patterns.
Research on real time detection of departure angle for the laser beam through atmospheric channels (2011)

The precision of departure angle detection for the laser beam can be improved by optimizing algorithms by which the high precision and stability of the laser beam pointing and tracking would be obtained, namely, improving the performance and accommodation of the free space optical communications. Atmospheric turbulence-induced optical intensity scintillations have a strong impact on the location precision of the laser spot through the atmospheric channels. Consequently, new requests come into view for the optimization of the algorithms. In the paper, the advantages and disadvantages of the traditional centroid method are analyzed. In terms of variations of laser spot, combined with the requests for real-time detection of departure angle, we proposed a new detection method. The edge of the laser spot on the detection sensor was redefined, and then the redefined spot was used to calculate the departure angle of the laser beam. The results of the simulations and experiments show that the precision of departure angle detection has been improved by more than 16%, which could reduce the effect of detection errors on the tracking procedure.
Depth of field rendering via adaptive recursive filtering (2014)

We present a new post-processing method for rendering high-quality depth-of-field effects in real time. Our method is based on a recursive filtering process, which adaptively smooths the image frame with local depth and circle of confusion information. Unlike previous post-filtering approaches that rely on various convolution kernels, the behavior of our filter is controlled by a weighting function defined between two neighboring pixels. By properly designing this weighting function, our method produces spatially-varying smoothed results, correctly handles the boundaries between in-focus and out-of-focus objects, and avoids rendering artifacts such as intensity leakage and blurring discontinuity. Additionally, our method works on the full frame without resorting to image pyramids. Our algorithms runs efficiently on graphics hardware. We demonstrate the effectiveness of the proposed method with several complex scenes.
Computer modeling of the write process in perpendicular recording (1986)

A self-consistent computer simulation model utilizing a ring head and single layer recording medium has been developed to study perpendicular recording. In the model it is assumed that the medium switches uniformly following the volume averaged field. The optimum recording field obtained from the model calculation at various head-medium spacings permits an estimation of head saturation limitations. The roll-off curve, which is the linear superposition of the alternating voltage pulses, is in good agreement with experimental data. The write spacing loss is spacing dependent and is 120d/λ (dB) at contact for a typical recording case. For contact recording the imaging effect is important in the write process. Optimum recording at contact is shown to produce a high overshoot and sharp leading edge in the transition while leaving the magnetization level below the coercivity; this yields an apparent "negative" transition length in terms of the arctangent transition model.
Love for Allah and love for self: exploring the connection between religious affect and self-esteem among Muslim adolescents in England (2022)

The connection between religious affect and self-esteem has been supported by a series of studies conducted among Christian or post-Christian samples. The present study extends this research tradition among a sample of 919 self-identified Muslim adolescents (between the ages of 11 and 14 years) attending schools in England. The data demonstrated that, after controlling for personal factors (age and sex) and for psychological factors (extraversion, neuroticism, and psychoticism), there was a significant positive association between the two core variables (religious affect and self-esteem). From the perspective of the empirical psychology of religion this study confirms among a Muslim sample a finding previously recorded among Christian or post-Christian samples.\n\n
Monitoring Prednisone and Prednisolone (1980)

Their common clinical use, frequency of adverse effects, serious therapeutic indications, treatment failures, and availability of sensitive assays make corticosteroids such as prednisone and prednisolone candidates for therapeutic drug monitoring. Complicating the interpretation of plasma drug concentrations are the first-pass metabolism of inactive prednisone to active prednisolone and reconversion. Also, the volume of distribution, metabolic clearance, and renal clearance of prednisolone increase with dose. This is due partly to saturable binding of prednisolone to transcortin in plasma, which provides more unbound drug at higher plasma concentrations of steroid. This effect plus the probable uptake of only unbound drug into intracellular receptor sites provides the rationale for measuring free prednisolone in plasma. Drug interactions between prednisolone and anticonvulsants are common. Liver and kidney disease have only limited effects on prednisolone disposition. Changes in clinical efficacy and appearance of side effects have been related to altered prednisolone clearance. Plasma concentrations may be used to determine disease and drug interactions, bioavailability, and patient compliance. The role of pharmacokinetic factors in governing the indirect and variable pharmacodynamic response to corticosteroids at various tissue sites and in disease states currently needs clarification.
Small submerged vortex generators for turbulent flow separation control (1990)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
HLA-DR2 subtypes form an additional supertypic family of DR beta alleles. (1987)

Homozygous lymphoblastoid cell lines representing Dw subtypes of the DR2 serotype were studied for structural polymorphism at DR beta. These subtypes included Dw2, Dw12, and non-Dw2/non-Dw12. Analysis by two-dimensional gel electrophoresis showed that two DR beta genes were expressed in each cell line studied. One of these expressed genes encoded a protein that was nonpolymorphic on two-dimensional gel electrophoresis among all subtypes. The second expressed DR beta gene was polymorphic and migrated to a position on two-dimensional gels dependent on the subtype of the cell line. cDNA sequence analysis of the DR beta genes revealed a DR beta gene identical between the Dw2 and Dw12 subtypes, which correlates with the nonpolymorphic spot on two-dimensional gels. A second gene was sequenced that exhibited variability between the Dw2 and Dw12 subtypes. This variability takes the form of clustered point mutations in the first domain of the molecules. The alleles from the DR beta genes of a non-Dw2/non-Dw12 cell line, AZH, were unusual in sequence. In contrast to other DR beta alleles, the AZH genes may have been generated by a double recombinational event between two DR beta loci from a DR2 parent. The DR2 serotype may also constitute a supertypic "family," with one DR beta gene relatively nonpolymorphic, and one that varies with Dw subtype.
Adsorption of alkanes on stoichiometric and oxygen-rich RuO<sub>2</sub>(110) (2016)

We investigated the molecular adsorption of methane, ethane, propane and n-butane on stoichiometric and oxygen-rich RuO2(110) surfaces using temperature-programmed desorption (TPD) and dispersion-corrected density functional theory (DFT-D3) calculations. We find that each alkane adsorbs strongly on the coordinatively-unsaturated Ru (Rucus) atoms of s-RuO2(110), with desorption from this state producing a well-defined TPD peak at low alkane coverage. As the coverage increases, we find that alkanes first form a compressed layer on the Rucus atoms and subsequently adsorb on the bridging O atoms of the surface until the monolayer saturates. DFT-D3 calculations predict that methane preferentially adsorbs on top of a Rucus atom and that the C2 to C4 alkanes preferentially adopt bidentate configurations in which each molecule aligns parallel to the Rucus atom row and datively bonds to neighboring Rucus atoms. DFT-D3 predicts binding energies that agree quantitatively with our experimental estimates for alkane σ-complexes on RuO2(110). We find that oxygen atoms adsorbed on top of Rucus atoms (Oot atoms) stabilize the adsorbed alkane complexes that bind in a given configuration, while also blocking the sites needed for σ-complex formation. This site blocking causes the coverage of the most stable, bidentate alkane complexes to decrease sharply with increasing Oot coverage. Concurrently, we find that a new peak develops in the C2 to C4 alkane TPD spectra with increasing Oot coverage, and that the desorption yield in this TPD feature passes through a maximum at Oot coverages between ∼50% and 60%. We present evidence that the new TPD peak arises from C2 to C4 alkanes that adsorb in upright, monodentate configurations on stranded Rucus sites located within the Oot layer.