gebhart/patrepeval huggingface dataset:
Inkjet-printed graphene-based wireless gas sensor modules (2012)

In this paper we demonstrate the use of graphene as the basis for design and development of low-cost, self-powered, battery-less, wireless sensor solutions utilizing thin films produced from environmentally friendly, water-based, inkjet printed graphene oxide (GO) ink. The in-house developed novel sensor material demonstrates good response to ammonia gas (NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ), yielding a 6% normalized resistance change within 15 minutes of exposure to a concentration of 500 ppm. In addition, excellent recovery time is achieved using the RGO thin films, with over 30% of material recovery observed within 5 minutes without exposure to high temperature or any UV treatments. Finally, we present in this work important distinctive characteristics in the behavior of the RGO sensor when exposed to different types of gases, including the hard-to-detect CO gas, that can be exploited in order to further enhance the applicability of the material. The introduction of mass producible, stable, environmentally friendly, inkjet-printable GO on organic paper/kapton substrates lays the foundation for the development of a wide range of new low-cost, high performance graphene-based devices, such as inkjet-printed diodes, capacitors and transistors.
Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation. (1998)

Treatment options in acute stroke are limited by a dearth of safe and effective regimens for recanalization of an occluded cerebrovascular tributary, as well as by the fact that patients present only after the occlusive event is established. We hypothesized that even if the site of major arterial occlusion is recanalized after stroke, microvascular thrombosis continues to occur at distal sites, reducing postischemic flow and contributing to ongoing neuronal death. To test this hypothesis, and to show that microvascular thrombosis occurs as an ongoing, dynamic process after the onset of stroke, we tested the effects of a potent antiplatelet agent given both before and after the onset of middle cerebral arterial (MCA) occlusion in a murine model of stroke. After 45 min of MCA occlusion and 23 h of reperfusion, fibrin accumulates in the ipsilateral cerebral hemisphere, based upon immunoblotting, and localizes to microvascular lumena, based upon immunostaining. In concordance with these data, there is a nearly threefold increase in the ipsilateral accumulation of 111In-labeled platelets in mice subjected to stroke compared with mice not subjected to stroke. When a novel inhibitor of the glycoprotein IIb/IIIa receptor (SDZ GPI 562) was administered immediately before MCA occlusion, platelet accumulation was reduced 48%, and fibrin accumulation was reduced by 47% by immunoblot densitometry. GPI 562 exhibited a dose-dependent reduction of cerebral infarct volumes measured by triphenyltetrazolium chloride staining, as well as improvement in postischemic cerebral blood flow, measured by laser doppler. GPI 562 caused a dose-dependent increase in tail vein bleeding time, but intracerebral hemorrhage (ICH) was not significantly increased at therapeutic doses; however, there was an increase in ICH at the highest doses tested. When given immediately after withdrawal of the MCA occluding suture, GPI 562 was shown to reduce cerebral infarct volumes by 70%. These data support the hypothesis that in ischemic regions of brain, microvascular thrombi continue to accumulate even after recanalization of the MCA, contributing to postischemic hypoperfusion and ongoing neuronal damage.
Space-Time Hole Filling With Random Walks in View Extrapolation for 3D Video (2013)

In this paper, a space-time hole filling approach is presented to deal with a disocclusion when a view is synthesized for the 3D video. The problem becomes even more complicated when the view is extrapolated from a single view, since the hole is large and has no stereo depth cues. Although many techniques have been developed to address this problem, most of them focus only on view interpolation. We propose a space-time joint filling method for color and depth videos in view extrapolation. For proper texture and depth to be sampled in the following hole filling process, the background of a scene is automatically segmented by the random walker segmentation in conjunction with the hole formation process. Then, the patch candidate selection process is formulated as a labeling problem, which can be solved with random walks. The patch candidates that best describe the hole region are dynamically selected in the space-time domain, and the hole is filled with the optimal patch for ensuring both spatial and temporal coherence. The experimental results show that the proposed method is superior to state-of-the-art methods and provides both spatially and temporally consistent results with significantly reduced flicker artifacts.
Novel Single Nucleotide Polymorphisms in the Distal IL-10 Promoter Affect IL-10 Production and Enhance the Risk of Systemic Lupus Erythematosus (2001)

Family studies of first-degree relatives and analysis of twins indicate that as much as 75% of the differences in quantitative IL-10 production in man derive from heritable genetic factors. Studies of single nucleotide polymorphisms (SNP) in the proximal 1.0 kb of the IL-10 promoter have yielded inconsistent association with IL-10 production and variable results in promoter-reporter studies. However, in normal donors, an association of quantitative production with certain alleles of the IL-10.R short tandem repeat polymorphism at -4.0 kb suggested that SNPs in the more distal promoter might be informative. We have identified seven novel SNP sites in the genomic sequence of the first 4 kb of the IL-10 promoter region 5' to the ATG start site from Caucasian individuals with either a high or a low IL-10 production phenotype. We have also identified eight SNP haplotypes in the distal promoter that segregate with significant differences in quantitative IL-10 production in normal donors. These SNPs are significantly associated with systemic lupus erythematosus in African-Americans and may define one component of the genetic susceptibility to systemic lupus erythematosus in this group.
Dietary Flavonoid Intake and Risk of Cardiovascular Disease in Postmenopausal Women (1999)

Flavonoids, a group of phenolic compounds found in fruits and vegetables, are known to have antioxidant properties. They prevent low density lipoprotein oxidation in vitro and thus may play a role in the prevention of coronary heart disease (CHD). In 1986, in a prospective study of 34,492 postmenopausal women in Iowa, the authors examined the association of flavonoid intake with CHD and stroke mortality. Over 10 years of follow-up, 438 deaths from CHD and 131 deaths from stroke were documented. Total flavonoid intake was associated with a decreased risk of CHD death after adjusting for age and energy intake (p for trend = 0.04). This association was attenuated after multivariate adjustment. However, decreased risk was seen in each category of intake compared with the lowest. Relative risks and 95% confidence intervals of CHD death from lowest to highest intake category were 1.0, 0.67 (95% confidence interval (CI) 0.49-0.92), 0.56 (95% CI 0.39-0.79), 0.86 (95% CI 0.63-1.18), and 0.62 (95% CI 0.44-0.87). There was no association between total flavonoid intake and stroke mortality (p for trend = 0.83). Of the foods that contributed the most to flavonoid intake in this cohort, only broccoli was strongly associated with reduced risk of CHD death. The data of this study suggest that flavonoid intake may reduce risk of death from CHD in postmenopausal women.
STEALTH TERRAIN NAVIGATION FOR MULTI-VEHICLE PATH PLANNING (1992)

In this paper, we propose a method for solving visibility-based terrain path planning problems for groups of vehicles using data parallel machines. The discussion focuses on path planning for two groups of vehicles so that they move in a bounding overwatch manner. Furthermore, the planned paths for the vehicles themselves are subject to intervisibility constraints, configuration constraints, and different terrain traversabilities due to variations in terrain type and slope. A spatial-temporal sampling approach is adopted to discretize the solution space and facilitate fast computation on a data parallel machine. One of the key computations in the planning is the region-to-region visibility analysis, which is computationally expensive but essential to the choice of subgoals to carry out reconnaissance activities. A parallel algorithm for this analysis is developed. By reducing the communication complexity, our algorithm achieves much faster running time than traditional methods. The algorithms are implemented on a Connection Machine CM-2, and the experimental results show that the planning system effectively generates good paths.
Consistently applying updates to compositions of distributed OSGi modules (2008)

Updating software at runtime is a challenge that covers various aspects of software design and runtime systems. The OSGi Alliance has proposed and standardized a runtime system for composing Java applications out of modules, the OSGi Framework. The possibility to update modules at runtime and thereby dynamically change the application has been an intrinsic design decision of the framework architecture. With recent approaches to extend the OSGi model from single Java virtual machines to distributed systems, however, updates no longer only affect a single machine in the system. The specifications of OSGi and the upcoming proposals for distributed OSGi services do not answer the question how to consistently apply updates in such environments. In this paper, we explore a solution based on our R-OSGi system. We show how to extend the existing (local) OSGi update mechanism to consistently apply updates to multiple nodes of a distributed OSGi application.
Optical properties of superlattice and MQW laser diode (1985)

MBE grown GaAs–AlxGa1−xAs superlattice structure was investigated in terms of crystallography (x-ray diffraction and direct lattice-image observation by TEM) and optical properties (controllability of Eg, oppoiste Burstein shift, structure dependent refractive index and room-temperature exciton). New device properties are described for an MQW laser diode/waveguide. These include anisotropic gain, low absorption loss, and stable longitudinal mode oscillation under high-speed modulation. An MQW laser diode in the long wavelength region is presented, which is made using the GaSb–AlxGa1−xSb material system. Future prospects are also described.
Review of Liquid Desiccant Technology for HVAC Applications (2008)

A thermally driven air conditioner that uses liquid desiccants as the working fluid may be an attractive alternative to the compressor-based technology that is now used in most HVAC applications. The operation of a liquid-desiccant air conditioner is first explained and several basic concepts are reviewed. This review focuses on the development of liquid-desiccant conditioners and regenerators that are better suited to comfort conditioning (as opposed to industrial dehumidification). This includes work on conditioners and regenerators that use low flow rates of desiccants and have internal heat exchange. These conditioners and regenerators will have lower pump and fan power than packed-bed units, and will be much less likely to introduce desiccant droplets into the process air. Work to identify and develop regenerators that have COPs over 1.0 and research on alternative liquid desiccants is also reviewed.
The Bacterial Flora of the Intestine of Ascaris suum and 5-Hydroxytryptamine Production (1986)

Representative facultative anaerobes of the bacterial flora from the intestine of female Ascaris suum were isolated and identified. The number of bacteria in the intestine was approximately 4 X 10(9) per g wet weight of intestine. Seventeen of 19 of the isolated colonies were found to secrete 5-hydroxytryptamine in culture. Holding A. suum in an antibiotic-containing medium did not affect the levels of 5-hydroxytryptamine in the worm, which were 231 +/- 14 ng/g in antibiotic-media as compared to 250 +/- 16 ng/g in control media. This implied that the bacteria may not be contributing to the level of 5-hydroxytryptamine in the tissues of A. suum.
Effect of Electronic Structure on the Photoinduced Ligand Exchange of Ru(II) Polypyridine Complexes (2011)

The series of complexes [Ru(bpy)(2)(L)](2+), where bpy = 2,2'-bipyridine and L = 3,6-dithiaoctane (bete, 1), 1,2-bis(phenylthio)ethane (bpte, 2), ethylenediamine (en, 3), and 1,2-dianilinoethane (dae, 4), were synthesized, and their photochemistry was investigated. Photolysis experiments show that the bisthioether ligands in 1 and 2 are more easily photosubstituted by chloride ions, bpy, and H(2)O than the corresponding diammine complexes in 3 and 4 to generate the bis-substituted products. Electronic structure calculations show that bond elongation in the lowest energy triplet metal-to-ligand charge transfer ((3)MLCT) state compared to the ground state is greater for complexes containing bisthioether ligands than those with coordinated bidentate nitrogen atoms. This elongation in the excited state is attributed to Ru-S π-bonding character of the highest occupied molecular orbitals, which is not present in the diamine complexes. In the Ru→bpy (3)MLCT state, the lower electron density on the metal-centered highest occupied molecular orbital (HOMO) weakens the Ru-S bond and results in the greater photoreactivity of 1 and 2 relative to that of 3 and 4. The more efficient photoinduced ligand exchange of the complexes possessing thioether ligands results in binding of 1 and 2 to DNA upon irradiation.
Hypoxic preconditioning of human cardiosphere-derived cell sheets enhances cellular functions via activation of the PI3K/Akt/mTOR/HIF-1α pathway. (2017)

Cell sheet technology is a promising therapeutic strategy for the treatment of ischemic diseases such as myocardial infarction. We recently developed a novel protocol, termed "hypoxic preconditioning," capable of augmenting the therapeutic efficacy of cell sheets. Following this protocol, the pro-angiogenic and anti-fibrotic activity of cell sheets were enhanced by brief incubation of cell sheets under hypoxic culture conditions. However, the precise molecular mechanism underlying the hypoxic preconditioning of cell sheets is unclear. In the present study, we examined signal transducers in cell sheets to identify those responsive to hypoxic preconditioning, using cardiosphere-derived cell (CDC) sheets. We initially tested whether sheet-like structures were suitable for hypoxic preconditioning by comparing them with individual cells. Hypoxic preconditioning was more effective in sheeted cells than in individual cells. Expression of hypoxia inducible factor-1α (HIF-1α) and mammalian target of rapamycin (mTOR) were induced upon hypoxic preconditioning of cell sheets, as was the phosphoinositide 3-kinase (PI3K)/Akt pathway. In addition, hypoxic preconditioning increased phosphorylation of epidermal growth factor receptor (EGFR) and heat shock protein 60 (HSP60) in CDC sheets. Our findings provide novel insights into the utility of hypoxic preconditioning in cell sheet-based technologies for the treatment of ischemic diseases.
In-line Dosing of White Wine for Bentonite Fining with Centrifugal Clarification (2007)

In-line dosing with bentonite provides an alternative to traditional batch fining for the removal of haze-forming proteins from white wine. When combined with centrifugation, in-line dosing can reduce wine losses and quality downgrades. In this production-scale study, Chardonnay and Semillon-Chardonnay wines were fined with three commercially available bentonites. A contact time of approximately 3 minutes was adequate for adsorption of the haze-forming proteins. No significant sensory difference was observed in the wines treated by in-line dosing and by batch fining. However, some carryover of bentonite into the centrifuge product was observed. This carryover was substantially lower when using a sodium-calcium bentonite compared with a sodium bentonite. The carryover was also significantly reduced by operating the centrifuge at lower flow rates.
A complex water network contributes to high-affinity binding in an antibody–antigen interface (2015)

This data article presents an analysis of structural water molecules in the high affinity interaction between a potent tumor growth inhibiting antibody (fragment), J22.9-xi, and the tumor marker antigen CD269 (B cell maturation antigen, BCMA). The 1.89 Å X-ray crystal structure shows exquisite details of the binding interface between the two molecules, which comprises relatively few, mostly hydrophobic, direct contacts but many indirect interactions over solvent waters. These are partly or wholly buried in, and therefore part of, the interface. A partial description of the structure is included in an article on the tumor inhibiting effects of the antibody: "Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma", Mol. Oncol. 9 (7) (2015) pp. 1348-58.
An analysis of the orthogonality structures of convolutional codes for iterative decoding (2005)

The structures of convolutional self-orthogonal codes and convolutional self-doubly-orthogonal codes for both belief propagation and threshold iterative decoding algorithms are analyzed on the basis of difference sets and computation tree. It is shown that the double orthogonality property of convolutional self-doubly-orthogonal codes improves the code structure by maximizing the number of independent observations over two successive decoding iterations while minimizing the number of cycles of lengths 6 and 8 on the code graphs. Thus, the double orthogonality may improve the iterative decoding in both convergence speed and error performance. In addition, the double orthogonality makes the computation tree rigorously balanced. This allows the determination of the best weighing technique, so that the error performance of the iterative threshold decoding algorithm approaches that of the iterative belief propagation decoding algorithm, but at a substantial reduction of the implementation complexity.
Comparative analysis and integrative classification of NCI60 cell lines and primary tumors using gene expression profiling data (2006)

Taken together, we developed and applied a novel approach for systematic comparative analysis and integrative classification of NCI60 cell lines and primary tumors. Our results could provide guidance to the selection of appropriate cell lines for cancer research and pharmaceutical compound screenings. Moreover, this gene expression profile based approach can be generally applied to evaluate experimental model systems such as cell lines and animal models for human diseases.
Functional amyloid in <i>Pseudomonas</i> (2010)

Amyloids are highly abundant in many microbial biofilms and may play an important role in their architecture. Nevertheless, little is known of the amyloid proteins. We report the discovery of a novel functional amyloid expressed by a Pseudomonas strain of the P. fluorescens group. The amyloid protein was purified and the amyloid-like structure verified. Partial sequencing by MS/MS combined with full genomic sequencing of the Pseudomonas strain identified the gene coding for the major subunit of the amyloid fibril, termed fapC. FapC contains a thrice repeated motif that differs from those previously found in curli fimbrins and prion proteins. The lack of aromatic residues in the repeat shows that aromatic side chains are not needed for efficient amyloid formation. In contrast, glutamine and asparagine residues seem to play a major role in amyloid formation as these are highly conserved in curli, prion proteins and FapC. fapC is conserved in many Pseudomonas strains including the opportunistic pathogen P. aeruginosa and is situated in a conserved operon containing six genes, of which one encodes a fapC homologue. Heterologous expression of the fapA-F operon in Escherichia coli BL21(DE3) resulted in a highly aggregative phenotype, showing that the operon is involved in biofilm formation.
Structure−Activity Relationship Study and Drug Profile of<i>N</i>-(4-Fluorophenylsulfonyl)-<scp>l</scp>-valyl-<scp>l</scp>-leucinal (SJA6017) as a Potent Calpain Inhibitor (2003)

Novel N-arylsulfonyldipeptidyl aldehyde derivatives were prepared by DMSO oxidation from the corresponding dipeptide alcohol, and their potencies as calpain inhibitors were evaluated in vitro. Among them, N-(4-fluorophenylsulfonyl)-l-valyl-l-leucinal (8, SJA6017) potently inhibited calpains. 8 also inhibited cathepsin B and L but did not inhibit other cysteine proteases (interleukin 1beta-converting enzyme), serine proteases (trypsin, chymotrypsin, thrombin, factor VIIa, factor Xa), or proteasome. Preliminary cytotoxicity studies of 8 exhibited a relatively safe profile.
Thermal Capsulorrhaphy (2004)

The initial wave of enthusiasm for thermal capsulorrhaphy has subsided. Long-term clinical data were lacking until D'Alessandro et al's prospective study indicated the results were not as promising as the previously reported short-term studies. Complications including obliteration or attenuation of capsular tissue, axillary nerve injury, and chondrolysis have all been reported in recent years further raising concern about the widespread use of this procedure. The inexact nature of how much "shrinkage" is being performed has led surgeons to further develop surgical technique in capsular plication, shift, or advancement. Although it remains to be seen if these techniques will lead to good clinical outcomes, it appears that they more closely resemble the original operative procedure-anterior capsular shift.
Intelligent support for specifications transformation (1988)

The authors describe an expert system, the Specification-Transformation Expert System (STES), which is to translate requirements specifications into design specifications automatically during the development phase of the software life cycle. STES accepts as input a software-requirements specification expressed in terms of dataflow diagrams. Using rules that embody a structured design methodology, STES translates this specification into a template describing a structure chart. STES consist of a knowledge base and an inference engine. The knowledge base contains information on the structured-design methodology and heuristic guidelines to help determine when certain methods should be applied. Given a target software system's requirements specification, the STES inference engine can perform intelligent decision-making and determine a suitable architectural design specification for the software system being designed. STES was originally implemented in OPS5 on a VAX11/780 computer. It has since been ported to an Apollo DN 3000 workstation and integrated with a commercial CASE tool.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>