gebhart/patrepeval huggingface dataset:
The Arabidopsis Lectin Receptor Kinase LecRK-V.5 Represses Stomatal Immunity Induced by Pseudomonas syringae pv. tomato DC3000 (2012)

Stomata play an important role in plant innate immunity by limiting pathogen entry into leaves but molecular mechanisms regulating stomatal closure upon pathogen perception are not well understood. Here we show that the Arabidopsis thaliana L-type lectin receptor kinase-V.5 (LecRK-V.5) negatively regulates stomatal immunity. Loss of LecRK-V.5 function increased resistance to surface inoculation with virulent bacteria Pseudomonas syringae pv tomato DC3000. Levels of resistance were not affected after infiltration-inoculation, suggesting that LecRK-V.5 functions at an early defense stage. By contrast, lines overexpressing LecRK-V.5 were more susceptible to Pst DC3000. Enhanced resistance in lecrk-V.5 mutants was correlated with constitutive stomatal closure, while increased susceptibility phenotypes in overexpression lines were associated with early stomatal reopening. Lines overexpressing LecRK-V.5 also demonstrated a defective stomatal closure after pathogen-associated molecular pattern (PAMP) treatments. LecRK-V.5 is rapidly expressed in stomatal guard cells after bacterial inoculation or treatment with the bacterial PAMP flagellin. In addition, lecrk-V.5 mutants guard cells exhibited constitutive accumulation of reactive oxygen species (ROS) and inhibition of ROS production opened stomata of lecrk-V.5. LecRK-V.5 is also shown to interfere with abscisic acid-mediated stomatal closure signaling upstream of ROS production. These results provide genetic evidences that LecRK-V.5 negatively regulates stomatal immunity upstream of ROS biosynthesis. Our data reveal that plants have evolved mechanisms to reverse bacteria-mediated stomatal closure to prevent long-term effect on CO(2) uptake and photosynthesis.
Protein kinase C localization in the synaptic terminal of rod bipolar cells (1996)

The purpose of the present study was to elucidate the physiological mechanisms that determine the activation of protein kinase C (PKC) in rod bipolar cells (RBC) of mouse and goldfish. The localization of PKC in RBC was examined using immunoreactivity (IR) against the alpha species of the enzyme. After incubating the whole retina or dissociated cells in control or test solutions, PKC-IR was performed on retinal transverse sections or on isolated cells. Cell depolarization induced the transport of the PKC to the synaptic terminal of RBC. The transport of the enzyme was also induced upon incubating dissociated cells in a solution containing phorbol esters. Enzyme transport was inhibited when the isolated retina was incubated in solutions containing GABA or nifedipine. We conclude that calcium and diacylglycerol, which contribute to the activation of PKC in RBC, induce transport of the enzyme to the synaptic terminal where it is presumed to play its functional role.
An integrated machine learning: Utility theory framework for real-time predictive maintenance in pumping systems (2020)

Bearings are the most widely used mechanical parts in rotating machinery under high load and high rotational speeds. Operating continuously under such harsh conditions, wear and failure are imminent. Developing defects give rise to even-higher vibration and temperature levels. In general, mechanical defects in a machine cause high vibration levels. Therefore, bearing fault identification and early detection enables the maintenance team to repair the problem before it triggers catastrophic failure in the bearing. Machine downtime is thus avoided or minimized. This paper explores the use of Machine Learning (ML) integrated with decision-making techniques to predict possible bearing failures and improve the overall manufacturing operations by applying the correct maintenance actions at the right time. The accuracy of the Predictive Maintenance (PdM) module has been tested on real industrial production datasets. The paper proposes an effective PdM methodology using different ML algorithms to detect failures before they happen and reduce pump downtime. The performance of the tested ML algorithms is based on five performance indicators: accuracy, precision, F-score, recall, and an area under curve (AUC). Experimental results revealed that all tested ML algorithms are successful and effective. Furthermore, decision making with utility theory has been employed to exploit the probability of failures and thus help to perform the appropriate maintenance interventions. This provides a logical framework for decision-makers to identify the optimum action with the maximum expected benefit. As a case study, the model is applied on forwarding pumping stations belonging to the Sewerage Treatment Company (STC), one of the largest sewage stations in Qatar.
Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility (1997)

Experiments were performed in vivo and in vitro to date the onset of hepatic CYP2C isoforms and CYP2C-dependent activities during the perinatal period in humans. Proteins were not detected by immunoblotting in fetal livers and developed in the first few weeks after birth, irrespective of the gestational age at birth. Similarly, the hydroxylation of tolbutamide, a marker for CYP2C9 was undetected in fetal liver microsomes and rose in the first month after birth. In adult liver preparations, the hydroxylation of diazepam correlated well with the CYP3 A content of microsomes (r = 0.858, p < 0.01) and with the 6 beta hydroxylation of testosterone (r = 0.830, p < 0.005), whereas demethylation was related to the bulk of CYP2C proteins (r = 0.865, p < 0.005). In fetal liver microsomes, hydroxylation and demethylation activities accounted for less than 5% of the adult activities and both increased immediately after birth to reach adult activities at 1 year of age. When diazepam was given for sedative purpose in neonates and infants, the in-vivo urinary excretion of desmethyl diazepam, temazepam and oxazepam was extremely low in 1-2 day newborns (less than 5 nmol metabolites excreted in 24 h per kg body weight) and developed in the first week after birth. In newborns, barbiturates and to a lesser extent steroids, acted as inducers of CYP2C isoforms and increased tolbutamide hydroxylation, diazepam demethylation and diazepam hydroxylation by 2 to 10-fold. The surge of CYP2C proteins was caused by an accumulation of RNAs occurring in the first week after birth. The hepatic content in CYP2C8, 2C9 and 2C18 RNA displayed the same profile of evolution, which suggested a coregulation of their synthesis during the neonatal period. Taken together, these biochemical and clinical data enable dating of the onset of CYP2C proteins to the first weeks after birth, which is of considerable clinical importance in pediatric pharmacology.
Level Set method Based on New Image Force (2007)

It is hard to get good segmentation result by using the classic Level Set method for Magnetic Resonance Imaging (MRI) which has strong noises and weak edges. To solve these problems, this paper integrates clustering information of image with information of the region of interesting, and constructs a new velocity function based on this new image force. This new velocity function has better antinoise capability and can deal with images which have strong noises, weak edges and low contrast. The experiments showed the effective of this method.
Free Fatty Acid Receptors and Drug Discovery (2008)

Utilizing the human genome database, the recently developed G-protein-coupled receptor (GPCR) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs) and is proposed to play a critical role in a variety of physiologic homeostasis mechanisms. GPR40 and GPR120 are activated by medium- and long-chain FFAs, whereas GPR41 and GPR43 are activated by short-chain FFAs. GPR40, which is preferentially expressed in pancreatic beta-cells, mediates insulin secretion. On the other hand, GPR120, which is abundantly expressed in the intestine, functions as a receptor for unsaturated long-chain FFAs and promotes the secretion of glucagon-like peptide-1 (GLP-1). In this review, we summarize the identification, structure, and pharmacology of the receptors and speculate on the respective physiologic roles that FFA receptor family members may play.
Research and Application of Public Security Monitor Point Planning System based on GIS Platform (2013)

To effectively solve the problem of conflicts,uneven density,different standards and other issues in video monitor point layout in urban areas,and to achieve the unified planning,step by step,intensive management,resource sharing,and to achieve the overall objective of maximize the effectiveness of the monitoring system,we need to do scientific precision planning on the urban-wide video monitor point in the system.This article describes the GIS-based video monitor point planning system of the city,which reflects the integrated use of modern means of science and technology,and the artificial intervention.A planning software is developed,in order to complete the precise planning on layout of large urban video monitor point,and finally provide a visual basis for government investment at all levels,and to guide the different units,different regions to begin the construction of video monitor system.
Toward Photocontrolled Release Using Light-Dissociable Block Copolymer Micelles (2006)

ADVERTISEMENT RETURN TO ISSUEPREVNoteToward Photocontrolled Release Using Light-Dissociable Block Copolymer MicellesJinqiang Jiang, Xia Tong, Denis Morris, and Yue ZhaoView Author Information Département de chimie and Département de Physique, Université de Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1 Cite this: Macromolecules 2006, 39, 13, 4633–4640Publication Date (Web):May 23, 2006Publication History Received20 January 2006Revised3 April 2006Published online23 May 2006Published inissue 1 June 2006https://pubs.acs.org/doi/10.1021/ma060142zhttps://doi.org/10.1021/ma060142zbrief-reportACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views5273Altmetric-Citations373LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Fluorescence,Irradiation,Micelles,Polymers,Solution chemistry Get e-Alerts
A Smart Cage With Uniform Wireless Power Distribution in 3D for Enabling Long-Term Experiments With Freely Moving Animals (2015)

This paper presents a novel experimental chamber with uniform wireless power distribution in 3D for enabling long-term biomedical experiments with small freely moving animal subjects. The implemented power transmission chamber prototype is based on arrays of parallel resonators and multicoil inductive links, to form a novel and highly efficient wireless power transmission system. The power transmitter unit includes several identical resonators enclosed in a scalable array of overlapping square coils which are connected in parallel to provide uniform power distribution along x and y. Moreover, the proposed chamber uses two arrays of primary resonators, facing each other, and connected in parallel to achieve uniform power distribution along the z axis. Each surface includes 9 overlapped coils connected in parallel and implemented into two layers of FR4 printed circuit board. The chamber features a natural power localization mechanism, which simplifies its implementation and ease its operation by avoiding the need for active detection and control mechanisms. A single power surface based on the proposed approach can provide a power transfer efficiency (PTE) of 69% and a power delivered to the load (PDL) of 120 mW, for a separation distance of 4 cm, whereas the complete chamber prototype provides a uniform PTE of 59% and a PDL of 100 mW in 3D, everywhere inside the chamber with a size of 27×27×16 cm(3).
Characteristics of a Nonstoichiometric Gd <sub>3+δ</sub> (Al,Ga) <sub>5−δ</sub> O <sub>12</sub> :Ce Garnet Scintillator (2008)

We have developed a new nonstoichiometric Gd 3+δ (Al,Ga) 5−δ O 12 :Ce garnet scintillator for an X‐ray CT scanner. For commercially used scintillators, reproducible luminescence properties are of great importance. We have found that the afterglow properties of the garnet change drastically in the vicinity of the stoichiometric compositions. The most suitable properties are obtained at slightly excess (Gd,Ce) compositions from the stoichiometry. In order to investigate the afterglow properties, crystallography arrangements, phase equilibrium relationship between crystal phases, and luminescence characteristics of host material doped with different valence ions have been examined. The luminescence properties are explained by isoelectronic traps based on the difference in the electronegativity of the dopant and host ions, which would act as electron trap centers and hole trap centers within the band gap.
Second Harmonic Generation Studies of Interfacial Strain Engineering in BaZr<sub>0.2</sub>Ti<sub>0.8</sub>O<sub>3</sub> (2023)

Abstract Film ferroelectrics demonstrate large breakdown strength, high energy density, and many unique phenomena not found in bulk materials. In this investigation, a rhombohedral BaZr 0.2 Ti 0.8 O 3 (BZT) solid solution and various film‐substrate misfit strains are utilized to optimize the energy storage performance of ferroelectric thick films. Optical second harmonic generation is applied in both reflection and transmission geometries to reveal the renovation of entangled rhombohedral and tetragonal phases in the BZT films under compressive misfit strains. It is shown that the interfacial strain between the BZT film and substrate introduces the tetragonal domains. The competition between the tetragonal and rhombohedral phases creates the self‐assembled, anisotropically strained morphotropic structures to effectively accommodate the elastic and electrical stress fields through inside the thick BZT film. The BZT films demonstrate exceptional energy storage performance because of the adaptable nano‐domain structure within the bulk of the BZT films and may be engineered to optimize the superior performance of BZT films in energy storage.
Distribution of Acinetobacter species on human skin: comparison of phenotypic and genotypic identification methods (1997)

At least 19 genomic species are recognized as constituting the genus Acinetobacter. However, little is known about the natural reservoirs of the various members of the genus. An epidemiological study was therefore performed to investigate the colonization with Acinetobacter spp. of the skin and mucous membranes of 40 patients hospitalized in a cardiology ward and 40 healthy controls. Single samples were obtained once from each of nine different body sites, i.e., forehead, ear, nose, throat, axilla, hand, groin, perineum, and toe web. Identification of Acinetobacter isolates was achieved by using phenotypic properties and was compared to identification by amplified ribosomal DNA restriction analysis. Selected isolates were further investigated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis, ribotyping, and DNA-DNA hybridization. Plasmid profile analysis was used for epidemiological typing. Thirty patients (75%) and 17 controls (42.5%) were found to be colonized with Acinetobacter spp., and the colonization rates of patients increased during their hospital stay. The most frequently isolated species were Acinetobacter lwoffii (47%), A. johnsonii (21%), A. radioresistens (12%), and DNA group 3 (11%). In contrast, A. baumannii and DNA group 13TU, the most important nosocomial Acinetobacter spp., were found only rarely on human skin (0.5 and 1%, respectively) and their natural habitat remains to be defined. A good correlation between phenotypic and genotypic methods for identification of Acinetobacter spp. was observed, and only two isolates could not be assigned to any of the known DNA groups.
Review on the Efficacy and Safety of Mahuang and Ephedrine in the Treatment of Obesity -Focused on RCT- (2017)

The objective of this study was to summarize randomized clinical trials (RCTs) that have assessed efficacy and safety of mahuang and ephedrine on treatment of obesity and to propose better process of study. Methods: NLM Medline (pubmed), the Cochrane library, Scopus, Science Direct, RISS, KISS were systemically searched for clinical trials investigating the efficacy, safety of mahuang and ephedrine on treatment of obesity from 2000 to 2017. Results: 16 RCTs met all the inclusion criteria. In most reports, mahuang and ephedrine significantly reduced body weight, body fat mass. There were no serious adverse events associated with mahuang and ephedrine in all studies. Conclusions: In appropriate dose of mahuang and ephedrine for healthy adult was safe, and weight loss effect of mahuang and ephedrine was better than control group. Improved clinical practice guidelines should be developed for safe use of mahuang and ephedrine.
Applications of Smart Tagged RFID Tapes for Localization Services in Historical and Cultural Heritage Environments (2010)

Wireless systems providing accurate localization information to a visitor or a group of visitors moving in a cultural heritage area can be used to enhance/create new multimedia communication services aimed at improving their cultural experience. In this paper we propose an effective architecture for a low cost system providing localization information. It is based on the deployment of a (very) large number of passive RFIDs spared inside the cultural area. As shown in this paper, due to the adoption of smart tagged RFIDs tapes the setup and maintenance of the system is greatly simplified independently of the area (indoor and/or outdoor) where the localization system is deployed. System performances are analyzed by considering a study case. Evaluation is carried out in terms of the achievable accuracy in the position estimate and the costs of the RFID part of the system. Finally, a discussion on the additional wireless traffic required for transporting information for localization to the central (multimedia) server, is presented. Accuracy below one meter can be theoretically achieved by properly selecting the density of RFIDs e.g. the number of smart tapes and the RFIDs' distance on the tape.
Synthesis and analysis for a novel single-stage isolated high power factor correction converter (2005)

A novel single-stage isolated high power factor correction (HPFC) converter operating in the discontinuous conduction mode is proposed in this paper. It is an integration of a buck-boost converter with a flyback converter by means of components placement and synchronous switching technology. It can achieve HPFC, tight output voltage regulation and lower voltage stress of the bulk capacitor, which is independent of the loads. The small-signal mathematical model for the proposed converter is derived separately by the averaging method and the current injected equivalent circuit approach. The IsSpice simulations and experimental results successfully verify the dynamics and performances of the proposed converter.
Leaving the Limits of Linearity for Light Microscopy (2020)

Nonlinear microscopy has enabled additional modalities for chemical contrast, deep penetration into biological tissues, and the ability to collect dynamics on ultrafast timescales across heterogenous samples. The additional light fields introduced to a sample offer seemingly endless possibilities for variation to optimize and customize experimentation and the extraction of physical insight. This perspective highlights three areas of growth in this diverse field: the collection of information across multiple timescales, the selective imaging of interfacial chemistry, and the exploitation of quantum behavior for future imaging directions. Future innovations will leverage the work of the studies reviewed here as well as address the current challenges presented.
Examination of Listeria monocytogenes in milk products. (1989)

The aim of our examinations was to make clear whether listeriae occur in Hungarian milk products, first of all, in cheese. In the course of model-examinations, the most suitable enrichment- and isolation media were selected. An examination method was elaborated involving cold-enrichment and KOH treatment. Milk samples from different parts of the country and cheeses produced by different technologies were examined. To the present, 80 raw milk samples and 100 cheese samples were examined. Listeria monocytogenes could be detected in 3 raw milk and 2 cheese samples.
The cookie recipe: Untangling the use of cookies in the wild (2017)

Users online are commonly tracked using HTTP cookies when browsing on the web. To protect their privacy, users tend to use simple tools to block the activity of HTTP cookies. However, the “block all” design of tools breaks critical web services or severely limits the online advertising ecosystem. Therefore, to ease this tension, a more nuanced strategy that discerns better the intended functionality of the HTTP cookies users encounter is required. We present the first large-scale study of the use of HTTP cookies in the wild using network traces containing more than 5.6 billion HTTP requests from real users for a period of two and a half months. We first present a statistical analysis of how cookies are used. We then analyze the structure of cookies and observe that; HTTP cookies are significantly more sophisticated than the name=value defined by the standard and assumed by researchers and developers. Based on our findings we present an algorithm that is able to extract the information included in 86% of the cookies in our dataset with an accuracy of 91.7%. Finally, we discuss the implications of our findings and provide solutions that can be used to improve the most promising privacy preserving tools.
Nonsynaptic Error Backpropagation in Long-Term Cognitive Networks (2019)

We introduce a neural cognitive mapping technique named long-term cognitive network (LTCN) that is able to memorize long-term dependencies between a sequence of input and output vectors, especially in those scenarios that require predicting the values of multiple dependent variables at the same time. The proposed technique is an extension of a recently proposed method named short-term cognitive network that aims at preserving the expert knowledge encoded in the weight matrix while optimizing the nonlinear mappings provided by the transfer function of each neuron. A nonsynaptic, backpropagation-based learning algorithm powered by stochastic gradient descent is put forward to iteratively optimize four parameters of the generalized sigmoid transfer function associated with each neuron. Numerical simulations over 35 multivariate regression and pattern completion data sets confirm that the proposed LTCN algorithm attains statistically significant performance differences with respect to other well-known state-of-the-art methods.