gebhart/patrepeval huggingface dataset:
A phase II trial of neoadjuvant erlotinib in patients with muscle‐invasive bladder cancer undergoing radical cystectomy: clinical and pathological results (2010)

The EGFR inhibitor erlotinib, when administered in the neoadjuvant setting, can have beneficial effects in terms of surgical pathology and short-term clinical outcomes in patients undergoing RC for invasive bladder cancer. Analyses are underway to examine the molecular correlates of the apparent clinical effect of neoadjuvant therapy in these patients.
Possible role of ceramide in defining structure and function of membrane glycolipids. (1982)

A possible role of ceramide in defining the carbohydrate structure of glycolipids and the expression of glycolipid function has been proposed, on the basis of our finding that the ceramide composition of "lacto-series" glycosphingolipid isolated from human erythrocytes shows a remarkable correlation with the terminal carbohydrate structure: (i) The ceramides of three glycosphingolipids with Lex (or x) determinant [Gal beta 1 leads to 4(Fuc alpha 1 leads to 3) GlcNAc] had almost exclusively 16:0 fatty acid; in contrast, the ceramide of its positional isomer H determinant had mainly 20--24:0 fatty acids. (ii) The ceramide of two glycosphingolipids with NeuAc alpha 2 leads to 6GAL structure was predominantly of 16:0 fatty acid, in contrast to that of its positional isomer NeuAc alpha 2 leads to 3Gal residue, in which the ceramide had 20--24:0 fatty acids. These results, together with our previous observation that ceramide composition of mouse lymphoma and myelocytic leukemia MI cells affects their antigenicity, suggest that ceramide structure may define the organization of glycosyltransferase for synthesis of the carbohydrate determinants and may affect the organization and orientation of the carbohydrate chain in membranes, eliciting or suppressing the reactivity to its ligand. Because these glycolipids with Lex and NeuAc alpha 2 leads to 6Gal structures are developmentally regulated and are highly expressed in certain tumors, ceramide composition may affect development, differentiation, and oncogenesis.
Single Molecular Multianalyte (Ca<sup>2+</sup>, Mg<sup>2+</sup>) Fluorescent Probe and Applications to Bioimaging (2005)

Intracellular signal transduction relies on spatial and temporal signal transmitter dynamics. To clarify the correlations of these transmitter molecules, multicolor-imaging has been widely used. However, in the case of applying multiple indicators in a cell, spectral overlap of the indicators prevents accurate quantitative analysis. Moreover, the invasive (toxic) effect, the localization, the metabolism, as well as photobleaching of these indicators complicate the situation. Here, we show that single-molecular multifluorescent probes can overcome these problems. While intracellular calcium plays a critical role as a signal transmitter and magnesium acts as a cofactor in many situations, the correlations between the two cations are now the main issue. We designed and synthesized a Ca2+-Mg2+ responsive multifluorescent probe, KCM-1. KCM-1 shows a spectral blue shift upon complexation to Ca2+ and a red shift to the presence of Mg2+. With data analyzed at different excitation wavelengths, the concentrations of Ca2+ and Mg2+ are simultaneously quantified. Furthermore, by using the AM-ester method, intracellular Ca2+ and Mg2+ concentrations are simultaneously imaged. Such a type of intracellular multiple analyte imaging by a single-molecular multifluorescent probe is successfully demonstrated for the first time.
Location linked information (2003)

This work builds an infrastructure called Location Linked Information that offers a means to associate digital information with public, physical places. This connection creates a hybrid virtual/physical space, called glean space, that is owned, managed, and rated by the public, for the benefit of the populace. Initially embodied by an interactive, dynamic map viewed on a handheld computer, the system provides two functions for its urban users: 1) the retrieval of information about their surroundings, and 2) the optional annotation of location for communal benefit. Having the ability to link physical location with arbitrary information is an essential function to building immersive information environments and the smart city. Public computing systems such as Location Linked Information will enhance the urban experience, just as access to transportation dramatically altered the sensation and form of the city.
Low cost MMSE algorithm for UTRA TDD mode downlinkreceiver (1998)

A low cost receiver algorithm is presented for the downlink in the emerging third generation mobile radio system time division duplexed mode. The receiver implements a minimum mean square error process at the same cost as a matched filter. This simplifies handset design and allows the network maximum flexibility in allocating timeslots and code channels.
Write Spacing Loss in Perpendicular Magnetic Recording (1987)

A relatively simple method is introduced to form microspacing between a probe-type head and a Co-Cr/Ni-Fe double-layer medium to investigate the effects of submicron spacing on perpendicular magnetic recording characteristics. It was shown experimentally that, as the spacing becomes large in recording, the reproduced voltage in saturation recording decreases. This phenomenon may be caused by the following: with increasing spacing, the recorded magnetization transition width in the medium is lengthened by decreasing write head field gradient resulting from the disappearance of the main pole-to-medium magnetic interaction.
Transferring GANs: generating images from limited data (2018)

Transferring the knowledge of pretrained networks to new domains by means of finetuning is a widely used practice for applications based on discriminative models. To the best of our knowledge this practice has not been studied within the context of generative deep networks. Therefore, we study domain adaptation applied to image generation with generative adversarial networks. We evaluate several aspects of domain adaptation, including the impact of target domain size, the relative distance between source and target domain, and the initialization of conditional GANs. Our results show that using knowledge from pretrained networks can shorten the convergence time and can significantly improve the quality of the generated images, especially when the target data is limited. We show that these conclusions can also be drawn for conditional GANs even when the pretrained model was trained without conditioning. Our results also suggest that density may be more important than diversity and a dataset with one or few densely sampled classes may be a better source model than more diverse datasets such as ImageNet or Places.
Catalytic, Highly Enantioselective, Direct Amination of β‐Ketoesters (2003)

Optically active α-amino acid derivatives were accessed through the direct asymmetric α-amination of α-substituted β-ketoesters 1, catalyzed by chiral CuII–bisoxazoline (BOX) complexes. The reaction proceeds with dibenzyl azodicarboxylate in the presence of only 0.2 mol % of the catalyst to give the desired products 2 in high yield with excellent enantioselectivity (up to 99 % ee). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z50655_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effects of dexmedetomidine infusion in patients undergoing functional endoscopic sinus surgery under local anaesthesia (2007)

These results suggest that dexmedetomidine provides analgesia, adequate sedation and surgical comfort without adverse effects for patients undergoing functional endoscopic sinus surgery under local anaesthesia.
[Relationship between adiponectin receptor 1 gene -3881T/C variant and glucose metabolism in the Chinese]. (2007)

These findings suggest that variant of ADIPOR1 plays a role in glucose metabolism and insulin resistance in the Chinese.
Picosecond laser studies on photochemical reactions in restricted environments: the photoisomerization of trans-stilbene complexed to cyclodextrins (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPicosecond laser studies on photochemical reactions in restricted environments: the photoisomerization of trans-stilbene complexed to cyclodextrinsGert L. Duveneck, E. V. Sitzmann, Kenneth B. Eisenthal, and Nicholas J. TurroCite this: J. Phys. Chem. 1989, 93, 20, 7166–7170Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/j100357a028https://doi.org/10.1021/j100357a028research-articleACS PublicationsRequest reuse permissionsArticle Views267Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
[Molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia]. (2003)

Activation of apoptosis of myocardial cells and inflammatory mediators played important roles in myocardial cell injury after 6-hour severe hypoxia.
Influenza Vaccine in Heart Failure (2019)

In patients with HF, influenza vaccination was associated with a reduced risk of both all-cause and cardiovascular death after extensive adjustment for confounders. Frequent vaccination and vaccination earlier in the year were associated with larger reductions in the risk of death compared with intermittent and late vaccination.
LBS AUGMENTED REALITY ASSISTIVE SYSTEM FOR UTILITIES INFRASTRUCTURE MANAGEMENT THROUGH GALILEO AND EGNOS (2016)

Abstract. There is a continuous and increasing demand for solutions, both software and hardware-based, that are able to productively handle underground utilities geospatial data. Innovative approaches that are based on the use of the European GNSS, Galileo and EGNOS, sensor technologies and LBS, are able to monitor, document and manage utility infrastructures’ data with an intuitive 3D augmented visualisation and navigation/positioning technology. A software and hardware-based system called LARA, currently under develop- ment through a H2020 co-funded project, aims at meeting that demand. The concept of LARA is to integrate the different innovative components of existing technologies in order to design and develop an integrated navigation/positioning and information system which coordinates GNSS, AR, 3D GIS and geodatabases on a mobile platform for monitoring, documenting and managing utility infrastruc- tures on-site. The LARA system will guide utility field workers to locate the working area by helping them see beneath the ground, rendering the complexity of the 3D models of the underground grid such as water, gas and electricity. The capacity and benefits of LARA are scheduled to be tested in two case studies located in Greece and the United Kingdom with various underground utilities. The paper aspires to present the first results from this initiative. The project leading to this application has received funding from the European GNSS Agency under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 641460.
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity (2018)

clinicaltrials.gov Identifier: NCT00356213.
Regioselective Hydroxylation of 2,4-Lutidine: A Practical Synthesis of 4-Hydroxymethyl-2-methylpyridine (2002)

A practical synthesis of 4-hydroxymethyl-2-methylpyridine has been developed which makes use of Evans' regioselective lithiation of readily available 2,4-lutidine and trapping with dimethylformamide.
A Model-Based Approach to Adaptive Control Optimization in Milling (1986)

An adaptive control optimization system using a model to represent actual physical phenomena in milling is discussed. The model is used for the identification of physical parameters, the calculation of the temperature at the tool edges, and the estimation of the tool wear rate. The shear angle of the shear plane, the flank wear land length of the tool edge, the true contact area at the flank wear land, the radial depth and the axial depth of cut are identified as the physical parameters, the shear stress, and the hardness of the work material from bending moments and torque in the spindle generated by the cutting force. The temperature at the flank wear land is calculated from identified parameters. The tool wear is represented theoretically as the summation of the thermal, mechanical and shock wears. Each wear is calculated from identified parameters and the temperature at the tool edges. Adaptive control experiments to keep the tool-wear rate at a constant value verify that the total system works well. An adaptive control optimization system using the tool-wear rate equation is compared with an adaptive control constraint system using Taylor’s tool life equation in a computer simulation. The simulation shows that adaptive control optimization gives higher cost efficiency than adaptive control constraint when the process parameters vary.
Hazards of Bacterial Contamination of Blood Products (1993)

Post-transfusion bacterial sepsis is infrequent. It is, however, associated with a high mortality due to septic shock. This reflects the release of endotoxin from gram negative bacteria. Lesser transfusion reactions are usually under-reported. These are frequently caused by gram positive bacteria. Gram positive species such as staphylococci and other skin surface organisms may be cultured from platelets stored at room temperature. Typically, gram negative "psychrophyllic" species which survive storage at 4 degrees C are cultured from stored refrigerated blood implicated in transfusion reactions. These include Yersinia enterocolitica, Pseudomonas fluorescens etc. Bacterial contamination of the blood supply can occur via an endogenous or an exogenous source. Endogenous donor bacteraemia due to Y.enterocolitica may be asymptomatic or may follow an episode of gastroenteritis. Exogenous infections occur through some defect in the usual collection practice. Transfusion-acquired syphilis is now extremely uncommon. In the third world, beside the need for effective screening for viral pathogens, infections with protozoa, in particular plasmodia, trypanosoma and leishmania remain a major obstacle to ensuring safe blood supplies. Prevention of transfusion reactions demands rigorous attention to details of collection, storage, reissuing and infusion of blood products, as well as prompt treatment, testing and reporting of suspected reactions.
Future Directions in Cancer Research: Impact of the Completion of the Human Genome (2004)

The sequencing of the human genome will have a major impact on the prevention, diagnosis, treatment, monitoring, and outcome of cancer. Progress will most likely occur in a stepwise fashion with the biggest initial impact in diagnosis and molecular targeting of new medicines. Advances in genomics and proteomics have already resulted in major findings that are facilitating earlier cancer diagnosis and disease stratification. New treatments that target specific pathways are well underway for many cancers and likewise, molecular analyses aimed at finding medicines with reduced toxicities are being conducted. Close interaction with the Food and Drug Administration will be very important to integrate these new technologies into product development and the approval of new medicines and diagnostics. Clearly, we are now approaching the era of personalized medicines in which one has the opportunity to maximize the efficacy and minimize the side effects of the cancer treatments. The ability to translate this new technology into improving cancer patient care and outcomes will require that scientists from academia, industry, and govemment work together closely to develop the framework and standards necessary to maximize the benefit of the human genome project.
The Klan Issue: How French Canadians Combatted Nativism through 1920 Maine Local Politics (2018)

In America’s Age of Trump, we must all consider the long history of white nationalism. The 2016 presidential election paved the way for a resurgence and more public appearance of this type of bigotry. Often falling under the general use of the “Alt-Right,” white nationalism became associated with Donald Trump and his presidency through multiple avenues and occasions. David Duke, a former Grand Wizard of the Ku Klux Klan, endorsed Trump for president and, later, his actions while in office, forcing the American public to question Trump’s stance on racism and white nationalism. Trump’s reluctance to denounce immediately Duke’s support fired up the Alt-Right base, while simultaneously inciting anger from many Americans. The tipping point for most Americans occurred with the Unite the Right rally, where both white supremacists and white nationalists gathered in Charlottesville, Virginia on August 11 and 12, 2017, to protest the removal of a statue of Robert E. Lee. Counter-protesters met the white nationalists, then violence erupted and multiple injuries occurred. The clash resulted in one woman’s death. On the day of the rally, Trump did not condemn the white nationalists or supremacist groups. Instead, he waited two days and blamed both sides for the violence that had occurred. The Alt-Right did not take Trump’s comments seriously, as the New York Times shows in their article, “Trump Condemns Racists but Creates Fresh Uproar.” The President’s ability to allow white nationalists to feel comfortable and powerful in politics and society mirrors a time in the United States’ history when organizations such as the Ku Klux Klan felt that same level of comfort.
Loss of high-affinity prostacyclin receptors in platelets and the lack of prostaglandin-induced inhibition of platelet-stimulated thrombin generation in subjects with spinal cord injury. (1996)

Coronary artery disease is a leading cause of death in individuals with chronic spinal cord injury (SCI). However, platelets of those with SCI (n = 30) showed neither increased aggregation nor resistance to the antiaggregatory effects of prostacyclin when compared with normal controls (n = 30). Prostanoid-induced cAMP synthesis was similar in both groups. In contrast, prostacyclin, which completely inhibited the platelet-stimulated thrombin generation in normal controls, failed to do so in those with SCI. Scatchard analysis of the binding of [3H]prostaglandin E1, used as a prostacyclin receptor probe, showed the presence of one high-affinity (Kd1 = 8.11 +/- 2.80 nM; n1 = 172 +/- 32 sites per cell) and one low-affinity (Kd2 = 1.01 +/- 0.3 microM; n2 = 1772 +/- 226 sites per cell) prostacyclin receptor in normal platelets. In contrast, the same analysis in subjects with SCI showed significant loss (P < 0.001) of high-affinity receptor sites (Kd1 = 6.34 +/- 1.91 nM; n1 = 43 +/- 10 sites per cell) with no significant change in the low affinity-receptors (Kd2 = 1.22 +/- 0.23; n2 = 1820 +/- 421). Treatment of these platelets with insulin, which has been demonstrated to restore both of the high- and low-affinity prostaglandin receptor numbers to within normal ranges in coronary artery disease, increased high-affinity receptor numbers and restored the prostacyclin effect on thrombin generation. These results demonstrate that the loss of the inhibitory effect of prostacyclin on the stimulation of thrombin generation was due to the loss of platelet high-affinity prostanoid receptors, which may contribute to atherogenesis in individuals with chronic SCI.
Adaptive classifiers using ontogenetic neural networks with feedback (2002)

The authors give the results of software simulation of Hebbian (D. O. Hebb, 1949) associative learning. Ontogenesis in feedback neural networks similar to those devised by Hopfield implies an initial structure and a plan for associative learning with growth. Experimental results are given to show that the advantages of ontogenetic neural networks configured as adaptive classifiers include rapid adaptation, good performance in classifying correctly, and the ability to cope with high levels of noise in training and operation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Panel: Power Minimization in IC Design (1995)

Mobile and portable information systems are pushing electronics and the development process. In their wake are new requirements that drive low-power design. This is however by no means the only driving force behind the need for a dramatic reduction of power dissipation in digital ICs. There also exists a strong demand on producers of high end products to reduce power consumption. Power minimization is thus vital for different reasons in different applications. Design knowledge and experience in minimizing power while optimizing performance is very limited. Low-power design is in its infancy. The same can be said for design tools. The opportunities for ultra low power tools and methodologies that achieve dramatic reduction of power and push higher up the design entry point are all around us. However, the need for tools that broaden the low-power design envelope is not being articulated by the user community very strongly. This panel seeks to expose solutions that designers and EDA vendors have, to present proper vehicles for transferring the low power design techniques and methodologies to the user community, and to provide a forum for exploring what is still needed. What design paradigms make sense, what levels of accuracy and speed are acceptable to the users and what tools have the highest payoff are part of what this panel is all about.
Removal of Parabens from Aqueous Solution Using β-Cyclodextrin Cross-Linked Polymer (2010)

The removal of four parabens, methyl-, ethyl-, propyl-, and benzyl-paraben, by β-cyclodextrin (β-CD) polymer from aqueous solution was studied. Different β-CD polymers were prepared by using two cross-linkers, i.e., hexamethylene diisocyanate (HMDI) and toluene-2,6-diisocyanate (TDI), with various molar ratios of cross-linker. β-CD-HMDI polymer with molar ratio of 1:7 and β-CD-TDI polymer with ratio 1:4 gave the highest adsorption of parabens among the β-CD-HMDI and β-CD-TDI series, and were subsequently used for further studies. The adsorption capacity of β-CD-HMDI is 0.0305, 0.0376, 0.1854 and 0.3026 mmol/g for methyl-, ethyl-, propyl-, and benzyl-paraben, respectively. β-CD-TDI have higher adsorption capacities compared with β-CD-HMDI, the adsorption capacity are 0.1019, 0.1286, 0.2551, and 0.3699 mmol/g methyl-, ethyl-, propyl-, and benzyl-paraben respectively. The parameters studied were adsorption capacity, water retention, and reusability. Role of both cross-linker in adsorption, hydrophobicity of polymers, and adsorption capacity of different parabens were compared and discussed. All experiments were conducted in batch adsorption technique. These polymers were applied to real samples and showed positive results.