gebhart/patrepeval huggingface dataset:
Application of tree-structured regression for regional precipitation prediction using general circulation model output (2000)

This study presents a tree-structured regression (TSR) method to relate daily precipitation with a variety of free-atmosphere variables. Historical data were used to identify distinct weather patterns associated with differing types of precipitation events. Models were developed using 67% of the data for training and the remaining data for model validation. Seasonal models were built for each of 2 US sites: San Francisco, California, and San Antonio, Texas. The average correlation between observed and simulated daily precipitation data series is 0.75 for the training set and 0.68 for the validation set. Relative humidity was found to be the dominant variable in these TSR models. Output from an NCAR CSM (climate system model) transient simulation of climate change were then used to drive the TSR models in the prediction of precipitation characteristics under climate change. A preliminary screening of the GCM output variables for current climate, however, revealed significant problems for the San Antonio site. Specifically, the CSM missed the annual trends in humidity for the grid cell containing this site. CSM output for the San Francisco site was found to be much more reliable. Therefore, we present future precipitation estimates only for the San Francisco site.
Combining Quantitative and Qualitative Assessment Methods in Software Process Improvement (1998)

Since the Software Engineering Institute (SEI) in Pittsburgh developed the Capability Maturity Model for Software (CMM) the idea of using assessments to determine the state of an organisation’s current software processes has gained increasing momentum. However, the assessment process itself has not received nearly the same attention as the maturity models used in the assessments. This paper argues that a useful assessment process is one which combines quantitative and qualitative methods of studying an organisation’s software processes. To demonstrate this an experiment was carried out in a large Danish software organisation. The experiment supports the value of combining quantitative and qualitative assessment methods in software process improvement. Several implications of this are discussed towards the end of the paper.
Antioxidants Modulate Induction of Programmed Endothelial Cell Death (Apoptosis) by Endotoxin (1994)

These findings suggest a novel role for the hydroxyl radical as a nonlethal intracellular signal in endothelial cell apoptosis. Moreover, the results support a role for programmed cell death in the pathogenesis of multiple organ dysfunction syndrome and suggest novel strategies for prophylaxis and therapy of the most common cause of death in surgical intensive care units.
Autonomous Robotic Mining Excavation Using Fuzzy Logic and Neural Networks (1995)

This article describes our initial investigation into using neural networks and fuzzy behaviors for autonomous excavation control of a robotic front-end-loader-type mining machine. To utilize the experience and expertise from skilled human operators, a behavior-control approach based on fuzzy logic is developed. Nine typical behavior programs for general excavation tasks are constructed and implemented with fuzzy logic rules. Two neural networks are built to assess excavation situations and then select the corresponding behavior programs based on force/torque feedback data. Simple strategies for self-evaluation and fusion of fuzzy behaviors are presented. To verify the proposed approach, laboratory experiments are conducted using a PUMA 560 robot arm, a Zebra force/torque sensor, and a SUN workstation. Experimental results indicate that fuzzy behaviors are capable of reacting to unpredicted events during the excavation process and can complete the desired excavation goals successfully.
Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism (1991)

We describe several novel analogs of the seco-steroid 1,25(OH)2-vitamin D3[1,25(OH)2D3] and their effects on differentiation and proliferation of HL-60 human myeloid leukemic cells in vitro as well as their effects on calcium metabolism in vivo. The 1 alpha-25(OH)2-16ene-23yne-26,27F6-vitamin D3 is the most potent analog reported to date, having about 80-fold more activity than the reference 1,25(OH)2D3 for inhibition of proliferation and induction of differentiation of HL-60 cells. Also, this analog decreased RNA expression of MYC oncogene in HL-60 by 90% at 5 x 10(-10) mol/L. Intriguingly, intestinal calcium absorption and bone calcium mobilization mediated in vivo by 1 alpha-25(OH)2-16ene-23yne-26,27F6-D3 was found to be markedly (15-fold) less than that of 1,25(OH)2D3. In addition, 1 alpha-25(OH)2D3 bound to 1,25(OH)2D3 receptors of both HL-60 and intestine more avidly than did 1 alpha-25(OH)2-16ene-23yne-26,27F6-D3. This novel analog may open up new therapeutic strategies for several hematopoietic, skin, and bone abnormalities and may provide a new tool to understand how vitamin D3 seco-steroids induce cellular differentiation.
Synthesis and Characterization of Metal‐Centered, Six‐Membered, Mixed‐Valent, Heterometallic Wheels of Iron, Manganese, and Indium (2006)

Heptanuclear metal-centered, six-membered, mixed-valent, heterometallic wheels 1-3 of iron, manganese, and indium were prepared in a one-pot reaction from N-benzyldiethanolamine (H2L(1)), cesium carbonate, [PPh4]2[MnCl4], and FeCl3 or InCl3. All three complexes were characterized by the combination of elemental analysis, FAB mass spectroscopy, X-ray diffraction and cyclic voltammetry and in the case of 1 additionally by Mössbauer spectroscopy. In 1, four Mn(II) ions in the periphery are arranged in pairs alternating with one Fe(III) ion each, with an Fe(III) ion located in the center. In 2, three Mn(II) ions alternate with three In(III) ions, whereas in 3, four In(III) ions are arranged in pairs and alternate with one Mn(II) ion each. In 2 and 3 an Mn(II) ion is encapsulated in the center.
The Biomarker S100B and Mild Traumatic Brain Injury: A Meta-analysis (2018)

S100B serum analysis as a part of the clinical routine could significantly reduce the number of CT scans performed on children with mTBI. Sampling should take place within 3 hours of trauma. Cutoff levels should be based on pediatric reference ranges.
Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion. (1990)

The functional, high-affinity interleukin 2 receptor (IL-2R) consists of at least two receptor components, IL-2R alpha (p55) and IL-2R beta (p70-75). The cDNA encoding the murine IL-2R beta has been isolated by using the previously cloned cDNA for human IL-2R beta as a probe. Analysis of the cDNA revealed that the murine IL-2R beta shows a marked homology with the human IL-2R beta and that it is also structurally related to other cytokine receptors such as erythropoietin receptor. The cDNA-directed murine IL-2R beta formed high-affinity IL-2R in conjunction with the endogenous IL-2R alpha in a murine pro-B-cell line and could transduce IL-2-induced growth signal. In mouse lymphoma line EL-4, the IL-2R beta gene was found to be rearranged by the insertion of the long terminal repeat sequence of an intracisternal A particle, giving rise to constitutive expression of the IL-2R beta mRNA.
A catalogue of functional software requirement patterns for the domain of content management systems (2013)

Software requirement patterns have been proposed as an artifact for fostering requirements reuse. When we define these patterns for the functional part of a software system, we realize that most of patterns are specific of a software domain. This paper presents and analyzes a catalogue of functional software requirement patterns for the domain of content management, and gives an overview of how this catalogue has been constructed from the systematic analysis of 6 existing software specification documents with the support of expert assessment.
Renormalization algorithms for Quantum-Many Body Systems in two and higher dimensions (2004)

We describe quantum many--body systems in terms of projected entangled--pair states, which naturally extend matrix product states to two and more dimensions. We present an algorithm to determine correlation functions in an efficient way. We use this result to build powerful numerical simulation techniques to describe the ground state, finite temperature, and evolution of spin systems in two and higher dimensions.
Effect of Electrolyte Composition on Zn Electrode in Weak Acidic Aqueous Electrolyte (2016)

The electrochemical behavior of zinc and polyaniline (PANI) obtained by the oxidative polymerization of aniline in 1.0 M aqueous HC1 by (NH4)2S2O8 were investigated in ZnCl2 + NH4Cl (chloride electrolyte), (NH4)2SO4 + ZnSO4 (sulfuric acid electrolyte), and (NH4)2SO4 + ZnSO4 + (CH3COO)2Pb ( acetic acid electrolyte) with the addition of Na-citrate and Na-malonate. Compared with sulfuric acid electrolyte and acetic acid electrolyte, zinc electrode shows the minimum of charge transfer resistance (Rct) and lower corrosion current densities, and polyaniline (PANI) keep high electrochemical activity in the chloride electrolyte at pH 4.0. The formation of zinc dendrite and the hydrogen evolution of the zinc electrode were suppressed in chloride electrolyte. The potentials were limited to 1.5 V for charge and to 0.7 V for discharge at 50 mA g-1, obtained the initial discharge specific capacity of 109.5 mAh g-1, the columbic efficiency remained at around 100% after 1000 times charge-discharge cycles.
HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication (2002)

Certain HIV-encoded proteins modify host-cell gene expression in a manner that facilitates viral replication. These activities may contribute to low-level viral replication in nonproliferating cells. Through the use of oligonucleotide microarrays and high-throughput Western blotting we demonstrate that one of these proteins, gp120, induces the expression of cytokines, chemokines, kinases, and transcription factors associated with antigen-specific T cell activation in the absence of cellular proliferation. Examination of transcriptional changes induced by gp120 in freshly isolated peripheral blood mononuclear cells and monocyte-derived-macrophages reveals a broad and complex transcriptional program conducive to productive infection with HIV. Observations include the induction of nuclear factor of activated T cells, components of the RNA polymerase II complex including TFII D, proteins localized to the plasma membrane, including several syntaxins, and members of the Rho protein family, including Cdc 42. These observations provide evidence that envelope-mediated signaling contributes to the productive infection of HIV in suboptimally activated T cells.
A novel NAND structure with a BJT contact for the high density mask ROMs (2002)

A novel NAND cell structure with a PNP BJT, which amplifies the cell current, was proposed and fabricated. Its typical current gain is around 10 and the measured cell current is about 180 /spl mu/A at 25/spl deg/C. This amount is extremely high compared to that of the conventional NAND cell structure. This structure also keeps good current driving capability regardless of temperature variation while full MOS type degrades the characteristics. This results indicate that this new structure is a strong candidate for high performance and high density mask ROMs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Deregulation of Interferon Signaling in Malignant Cells (2010)

Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects <i>in vitro</i> and <i>in vivo</i>, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed.
Maximally Compact and Separated Features with Regular Polytope Networks (2023)

Convolutional Neural Networks (CNNs) trained with the Softmax loss are widely used classification models for several vision tasks. Typically, a learnable transformation (i.e. the classifier) is placed at the end of such models returning class scores that are further normalized into probabilities by Softmax. This learnable transformation has a fundamental role in determining the network internal feature representation. In this work we show how to extract from CNNs features with the properties of \emph{maximum} inter-class separability and \emph{maximum} intra-class compactness by setting the parameters of the classifier transformation as not trainable (i.e. fixed). We obtain features similar to what can be obtained with the well-known ``Center Loss'' \cite{wen2016discriminative} and other similar approaches but with several practical advantages including maximal exploitation of the available feature space representation, reduction in the number of network parameters, no need to use other auxiliary losses besides the Softmax. Our approach unifies and generalizes into a common approach two apparently different classes of methods regarding: discriminative features, pioneered by the Center Loss \cite{wen2016discriminative} and fixed classifiers, firstly evaluated in \cite{hoffer2018fix}. Preliminary qualitative experimental results provide some insight on the potentialities of our combined strategy.
Designing Control Systems with Knowledge (1987)

It is generally accepted that object-based systems provide a simple and elegant paradigm for general-purpose programming that meshed well with data models. In this paper we propose to use the object computation model as the basis for automatic control system design environment. Typically, an automatic control system design environment consists of a set of control system design experts that cooperate with each other. In addition to experts there are a number of control systems that have been designed or are to be designed. We propose to construct a knowledge base between such an environment and the users of the environment; Consequently a user sees the environment as a large knowledge base, and he or she can create, modify, retrieve, or query the knowledge base through knowledge base operations. Furthermore, the knowledge base can help the users to manage the inter-relationships between entities that reside in the environment, to represent abstract knowledge about control system design, and it can derive more knowledge about a plant once a minimal set of characteristics is provided.
CXCR3-binding Chemokines: Novel Multifunctional Therapeutic Targets (2005)

The goal to attenuate inflammation without inducing generalized immunosuppression has focused the attention on chemokines, a family of chemotactic peptides that regulate the leukocyte traffick into tissues. However, the development of drugs that block ckemokine activity may be hampered by the observation that some chemokines display pleiotropic biologic functions. For example, the chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC exhibit the ability to recruit different leukocytes subsets, the capacity to induce the proliferation of vascular pericytes as well as powerful anti-tumor effects, which are mediated by a common receptor, named CXCR3. Because of their pleiotropic biologic effects, these chemokines have been proposed as possible therapeutic targets in cancer, allograft rejection, glomerulonephritis, diabetes, multiple sclerosis, and autoimmune disorders of the thyroid. The chemokine CXCL4/PF4 shares several activities with CXCL9, CXCL10, and CXCL11, including angiostatic effects, although its specific receptor has remained unknown for a long time. Recently, we provided evidence that the different functions of CXCL9, CXCL10, and CXCL11 on distinct cell types can be at least partly explained by the interaction of these chemokines with two distinct receptors. Indeed, in addition to the classic form of CXCR3 receptor, which we have renamed as CXCR3-A, a novel CXCR3 receptor variant (CXCR3-B) was identified, that not only mediates the angiostatic activity of CXCR3 ligands, but also acts as functional receptor for CXCL4. In this review, we focus on the accumulating evidence demonstrating the pivotal role of CXCR3-binding chemokines in several human diseases. Studies based on CXCR3 targeting have shown its importance in different pathologic conditions and orally active small molecules capable of inhibiting this receptor are now being developed in order to be tested for their activity in humans.
A Collusion-Resistant Fingerprinting System for Restricted Distribution of Digital Documents (2013)

Digital fingerprinting is a technique that consists of inserting the ID of an authorized user in the digital content that he requests. This technique has been mainly used to trace back pirate copies of multimedia content such as images, audio, and video. This study proposes the use of state-of-the-art digital fingerprinting techniques in the context of restricted distribution of digital documents. In particular, the system proposed by Kuribayashi for multimedia content is investigated. Extensive simulations show the robustness of the proposed system against average collusion attack. Perceptual transparency of the fingerprinted documents is also studied. Moreover, by using an efficient Fast Fourier Transform core and standard computer machines it is shown that the proposed system is suitable for real-world scenarios.
Posttranscriptional control of puc operon expression of B800-850 light-harvesting complex formation in Rhodobacter sphaeroides (1989)

The puc operon of Rhodobacter sphaeroides comprises the pucBA structural genes which encode B800-850 light-harvesting beta and alpha polypeptides, respectively. Northern (RNA) blot hybridization analysis of puc operon expression has identified two pucBA-specific transcripts. The small (0.5-kilobase [kb]) transcript encodes the beta and alpha polypeptides and, under photoheterotrophic growth conditions, was approximately 200-fold more abundant than the large (2.3-kb) transcript. The 5' end of the 0.5-kb transcript was mapped at 117 nucleotides upstream from the start of pucB. The 3' ends of the 0.5-kb transcript were mapped to two adjacent nucleotides, which follow a stem-loop structure immediately 3' to the pucA stop codon. Two mutant strains, PUC705-BA and PUC-Pv, were constructed by replacement of the pucBA genes and adjacent DNA in the former case or by insertional interruption of the DNA downstream of the pucBA genes in the latter case. The two mutant strains were devoid of B800-850 complexes during photosynthetic growth but were otherwise apparently normal. The B800-850 phenotype of both PUC705-BA and PUC-Pv was not complemented in trans with a 2.5-kb PstI restriction endonuclease fragment extending from 0.75 kb upstream of pucBA to 1.3 kb downstream of pucBA, despite the presence of the 0.5-kb pucBA-specific transcript. Both of the mutant strains, however, showed restoration of B800-850 expression with a 10.5-kb EcoRI restriction endonuclease fragment in trans encompassing the 2.5-kb PstI fragment. Western immunoblot analysis revealed no B800-850-beta polypeptide as well as no polypeptide designated 15A in either mutant. Nonetheless, under photoheterotrophic growth conditions, the 0.5-kb pucBA-specific transcript was present in PUC-Pv, although no 2.3-kb transcript was detectable. We suggest that the DNA region immediately downstream of pucBA encodes a gene product(s) essential for translational or posttranslational expression of the B800-850 beta and alpha polypeptides.
Antenna-array pattern nulling using a differential evolution algorithm (2003)

A new method based on the differential evolution (DE) algorithm is proposed for antenna-array pattern synthesis with prescribed nulls. The array excitation amplitudes are the only controlling parameters, and the objectives are to synthesize array patterns with nulls imposed on directions of interferences while keeping the sidelobe levels (SLLs) below prescribed levels. Many factors such as the excitation dynamic range ratio, null depth level, null width, and SLLs are taken into account in the synthesis. Simulation results of several typical problems are compared with published results to illustrate the effectiveness of the proposed method. © 2003 Wiley Periodicals, Inc. Int J RF and Microwave CAE 14: 57–63, 2004.
Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels (2018)

Currently, neuropathic pain is an underestimated socioeconomic health problem affecting millions of people worldwide, which incidence may increase in the next years due to chronification of several diseases, such as cancer and diabetes. Growing evidence links neuropathic pain present in several disorders [i.e., spinal cord injury (SCI), cancer, diabetes and alcoholism] to central sensitization, as a global result of mitochondrial dysfunction induced by oxidative and nitrosative stress. Additionally, inflammatory signals and the overload in intracellular calcium ion could be also implicated in this complex network that has not yet been elucidated. Recently, calcium channels namely transient receptor potential (TRP) superfamily, including members of the subfamilies A (TRAP1), M (TRPM2 and 7), and V (TRPV1 and 4), have demonstrated to play a role in the nociception mediated by sensory neurons. Therefore, as neuropathic pain could be a consequence of the imbalance between reactive oxygen species and endogen antioxidants, antioxidant supplementation may be a treatment option. This kind of therapy would exert its beneficial action through antioxidant and immunoregulatory functions, optimizing mitochondrial function and even increasing the biogenesis of this vital organelle; on balance, antioxidant supplementation would improve the patient's quality of life. This review seeks to deepen on current knowledge about neuropathic pain, summarizing clinical conditions and probable causes, the relationship existing between oxidative stress, mitochondrial dysfunction and TRP channels activation, and scientific evidence related to antioxidant supplementation.
Application of supergrouping to land seismic data in desert environment (2016)

We apply supergrouping of land data after moveout corrections and prove that it can address noise issues caused by extreme near-surface scattering present in a desert environment. We demonstrate how supergrouping enhances pre-stack single-sensor data as well as data previously group-formed in the field. Improved statics, velocity estimation, and deconvolution operators obtained with supergrouping all lead to better images. Imaging of supergrouped data also has a clear advantage at least in simple structural settings. Presentation Date: Tuesday, October 18, 2016 Start Time: 8:00:00 AM Location: 140 Presentation Type: ORAL