gebhart/patrepeval huggingface dataset:
Abstract 1683: Novel combination approach using platinum drugs and mitochondrial division inhibitor 1 (mdivi-1) overcomes platinum resistance by synergistically inducing mitochondrial outer membrane permeabilization (MOMP) and apoptosis independent of Drp1 (2014)

Abstract Platinum based anticancer agents, including cisplatin, are among the most effective and widely used anticancer drugs. However, inherent and acquired resistance to these drugs in tumors lead to treatment failure. We found a class of thioquinazolinone derivatives, including the mitochondrial division inhibitor-1 (mdivi-1), that overcome both the inherent and acquired resistance to cisplatin in tumor cell lines and also in primary ovarian tumors isolated from cisplatin refractory patients. The combination of cisplatin and mdivi-1 produces synergistic effect in inducing rapid apoptosis. Using Drp1 (a mitochondrial fission protein and the reported target of mdivi-1) knockout MEF cells we demonstrated that the combination of cisplatin and mdivi-1 overcomes cisplatin resistance in a Drp1-independent manner. Mdivi-1 causes replication defects and its combination with cisplatin triggers synergistic increases of replication stress and DNA damage. Comparing the treatment with cisplatin and mdivi-1 alone, the combination of the two agents enhances mitochondrial apoptotic signaling by specifically upregulating the expression of a pro-apoptotic Bcl-2 family protein Noxa, which promotes Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP). Intriguingly, the combination of cisplatin and mdivi-1 also causes mitochondrial swelling that triggers a Bax/Bak-independent MOMP. Thus, the combination of cisplatin and mdivi-1 activates two distinct mechanisms that converge on mitochondria contributing to the enhancement of MOMP. This novel combination represents a potential effective strategy in overcoming platinum drug resistance by combining cisplatin with compounds that together are able to trigger the coinitiation of Bax/Bak-dependent and-independent mitochondrial apoptotic signaling. (Work was supported by P30CA047904, UPCI and PA Dept of Health CURE program) Citation Format: Wei Qian, Jingnan Wang, Vera Roginskaya, Lee McDermott, Robert Edwards, Donna Stolz, Fabien Llambi, Douglas Green, Bennett Van Houten. Novel combination approach using platinum drugs and mitochondrial division inhibitor 1 (mdivi-1) overcomes platinum resistance by synergistically inducing mitochondrial outer membrane permeabilization (MOMP) and apoptosis independent of Drp1. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1683. doi:10.1158/1538-7445.AM2014-1683
CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism (2013)

CTRP3 is a secreted plasma protein of the C1q family that helps regulate hepatic gluconeogenesis and is downregulated in a diet-induced obese state. However, the role of CTRP3 in regulating lipid metabolism has not been established. Here, we used a transgenic mouse model to address the potential function of CTRP3 in ameliorating high-fat diet-induced metabolic stress. Both transgenic and wild-type mice fed a high-fat diet showed similar body weight gain, food intake, and energy expenditure. Despite similar adiposity to wild-type mice upon diet-induced obesity (DIO), CTRP3 transgenic mice were strikingly resistant to the development of hepatic steatosis, had reduced serum TNF-α levels, and demonstrated a modest improvement in systemic insulin sensitivity. Additionally, reduced hepatic triglyceride levels were due to decreased expression of enzymes (GPAT, AGPAT, and DGAT) involved in triglyceride synthesis. Importantly, short-term daily administration of recombinant CTRP3 to DIO mice for 5 days was sufficient to improve the fatty liver phenotype, evident as reduced hepatic triglyceride content and expression of triglyceride synthesis genes. Consistent with a direct effect on liver cells, recombinant CTRP3 treatment reduced fatty acid synthesis and neutral lipid accumulation in cultured rat H4IIE hepatocytes. Together, these results establish a novel role for CTRP3 hormone in regulating hepatic lipid metabolism and highlight its protective function and therapeutic potential in attenuating hepatic steatosis.
Design of a Low Jitter Multi-Phase Realigned PLL in submicronic CMOS technology (2007)

This paper presents a novel PLL and VCO concept based on the multi-phase direct realignment. A multiphase realigned VCO and PLL operating in the 80-240MHz frequency range have been realized in 0.18 <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">μ</i> m standard CMOS process, with a 1.8V power supply voltage. A comparison between realigned and not realigned PLLs showed a jitter improvement by a factor 2 at 240MHz without increasing the power consumption, which is 2.4mW at 240MHz.
A fusion approach to cluster labeling (2014)

We present a novel approach to the cluster labeling task using fusion methods. The core idea of our approach is to weigh labels, suggested by any labeler, according to the estimated labeler's decisiveness with respect to each of its suggested labels. We hypothesize that, a cluster labeler's labeling choice for a given cluster should remain stable even in the presence of a slightly incomplete cluster data. Using state-of-the-art cluster labeling and data fusion methods, evaluated over a large data collection of clusters, we demonstrate that, overall, the cluster labeling fusion methods that further consider the labeler's decisiveness provide the best labeling performance.
High-Quality Capture of Documents on a Cluttered Tabletop with a 4K Video Camera (2015)

We present a novel system for detecting and capturing paper documents on a tabletop using a 4K video camera mounted overhead on pan-tilt servos. Our automated system first finds paper documents on a cluttered tabletop based on a text probability map, and then takes a sequence of high-resolution frames of the located document to reconstruct a high quality and fronto-parallel document page image. The quality of the resulting images enables OCR processing on the whole page. We performed a preliminary evaluation on a small set of 10 document pages and our proposed system achieved 98% accuracy with the open source Tesseract OCR engine.
Optical interconnection reverse Data Vortex network (2010)

In the present paper we describe the feasibility of Data Vortex architecture in reverse direction. The routing and the possible hardware model of the node switch have been discussed. A comparative study on reachability and fault tolerance is presented in both forward and reverse direction. Also, enhancement of fault tolerance using multiplexers has been calculated. The terminal reliability of the switch has also been evaluated.
Congenital diseases and Rho family dependent signal transduction (2001)

We have searched the human genome for genes that predispose to rheumatoid arthritis using microsatellite marker analysis and affected sib-pair linkage studies. Three principal chromosome regions of linkage, D1S253/214, D8S556 and DXS 1232/984, have been assigned for rheumatoid arthritis disease loci. We are now assigning the truncated form of Dbl proto-oncogene, which does not contain the 23rd and 24th exons, as a candidate gene for DXS 1232/984. Dbl proto-oncogene is one of the GDP/GTP exchange factors and activates Rho family GTPase. In this minireview, We describe our results and Rho family dependent signal transduction correlated with congenital diseases. Genetic linkage mapping and progress of genomic sequence-project will make it possible to identify new genes correlated with many diseases.
Development of 3D Measurement System Using Phase Shift Digital Holography (2015)

SUMMARY The demand for three‐dimensional (3D) measurement technology has been increasing, but in many of the traditional 3D measurement methods, such as the method using phase shift pattern projection, it is difficult to measure the shape of specular‐reflective and transparent objects, because the power of the light reflected from specular reflective objects is too high and that from transparent objects is too low. Consequently, digital cameras cannot acquire accurate information from reflected light. Digital holography has been used as a means of resolving this problem. In traditional digital holography, the interference fringes of the light from the object being measured and the reference light can be captured by a digital camera. Using the Fresnel diffraction principle, the phase information in the light from the object being measured can be acquired and the shape of the object can be calculated by interferometry. Digital holography can be used to measure reflective and transparent objects. However, by the principle of Fresnel diffraction, dc and conjugate components exist in the calculated phase information a noises, so that the accuracy of measurements is reduced. Phase shift digital holography can remove noise by using special devices to change the phase of the reference light, but the devices are costly and the systems are complex, so that practical application of phase shift digital holography has been difficult. In this paper, we propose a new method of phase shift digital holography using the light detection principle. We also propose a digital holography reconstruction method using the convolution approach rather than the traditional Fresnel approach. The proposed method results in a compact phase shift holography system with lower cost and greater accuracy than the 3D measurement method. Therefore, the practical applications of digital holography can be realized less expensively and more accurately.
A SWCNT based aptasensor system for antibiotic oxytetracycline detection in water samples (2019)

A simple and highly sensitive aptamer-based single walled carbon nanotubes (SWCNTs) biosensor for fast and specific oxytetracycline detection in environmental water samples.
A practical message-wise unequal error protection coding scheme (2010)

We propose a practical message-wise unequal error protection (UEP) scheme using low-density parity-check (LDPC) codes, where one or more special messages are more protected than other ordinary messages, which performs codeword flipping to separate the codewords of special and ordinary messages. To better distinguish the original and flipped codewords, the LDPC codes with all-odd degree check nodes are employed. The decoder performs message type detection and codeword flipping detection by tracking the number of unsatisfied check nodes in iterative decoding. We provide both finite-length and asymptotic performance analysis for the proposed coding scheme. Simulation results are provided to show that the proposed practical message-wise UEP schemes offer capacity-approaching protections to both types of messages as if only one type of message is transmitted.
2-Aryloxy-4-alkylaminopyridines: Discovery of Novel Corticotropin-Releasing Factor 1 Antagonists (2008)

An orally active clinical candidate of corticotropin-releasing factor 1 (CRF 1) antagonist 1 showed a significant positive food effect in dog and human after oral administration. Efforts to address the food effect issue led us to explore and discover compounds in series 2 as orally active CRF 1 receptor antagonists, in which some compounds showed improved physicochemical properties while retaining desired pharmacological properties. Compound 3a (CP-376395) was selected for further development, due not only to its reduced food effects but also its greater efficacy in CNS models. Compound 3a was advanced to the clinic. The synthesis of representative potential candidates and their in vitro, ex vivo, and in vivo data are described.
Highly Accurate Moving Object Detection in Variable Bit Rate Video-Based Traffic Monitoring Systems (2013)

Automated motion detection, which segments moving objects from video streams, is the key technology of intelligent transportation systems for traffic management. Traffic surveillance systems use video communication over real-world networks with limited bandwidth, which frequently suffers because of either network congestion or unstable bandwidth. Evidence supporting these problems abounds in publications about wireless video communication. Thus, to effectively perform the arduous task of motion detection over a network with unstable bandwidth, a process by which bit-rate is allocated to match the available network bandwidth is necessitated. This process is accomplished by the rate control scheme. This paper presents a new motion detection approach that is based on the cerebellar-model-articulation-controller (CMAC) through artificial neural networks to completely and accurately detect moving objects in both high and low bit-rate video streams. The proposed approach is consisted of a probabilistic background generation (PBG) module and a moving object detection (MOD) module. To ensure that the properties of variable bit-rate video streams are accommodated, the proposed PBG module effectively produces a probabilistic background model through an unsupervised learning process over variable bit-rate video streams. Next, the MOD module, which is based on the CMAC network, completely and accurately detects moving objects in both low and high bit-rate video streams by implementing two procedures: 1) a block selection procedure and 2) an object detection procedure. The detection results show that our proposed approach is capable of performing with higher efficacy when compared with the results produced by other state-of-the-art approaches in variable bit-rate video streams over real-world limited bandwidth networks. Both qualitative and quantitative evaluations support this claim; for instance, the proposed approach achieves Similarity and F1 accuracy rates that are 76.40% and 84.37% higher than those of existing approaches, respectively.
A 312-GHz CMOS Injection-Locked Radiator With Chip-and-Package Distributed Antenna (2017)

This paper presents an injected-locked THz radiator integrating a half-quadrature voltage-controlled oscillator (HQVCO), four injection-locked frequency quadruplers (ILFQs), and a chip-and-package distributed antenna (DA). At the system level, an architecture based on injection locking is employed to allow individual optimization of the output power and the phase noise. At the circuit level, intrinsic-delay compensation and harmonic boosting techniques are proposed to optimize the phase noise of the HQVCO and the output power of the ILFQs, respectively. The proposed DA composed of four exciting elements on silicon chip and a primary radiator in low-temperature co-fired ceramic (LTCC) package features a wide bandwidth of 13% and a gain of 3.8 dBi without using lens at 312 GHz. Implemented in a 65-nm CMOS process, the radiator system occupying a core area of 0.36 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> achieves output frequency from 311.6 to 315.5 GHz and maximum equivalent isotropically radiated power (EIRP) of 10.5 dBm while consuming 300 mW. The output phase noise measures -109.3 dBc/Hz at 10-MHz offset and the dc-to-THz efficiency is 0.42%.
Channelized, time- and space-integrating acousto-optic processor (1990)

A novel channelized, hybrid time- and space-integrating acoustooptic (AO) spectrum analyzer is described. The architecture consists of two AO cells in a crossed-cell configuration. The first AO cell is a wide bandwidth device that performs space-integrating spectral analysis and channelizes signals according to carrier frequency. The second AO cell, in conjunction with a modulated source, performs time-integrating spectral analysis of the signal envelope using the chirp algorithm. One possible application of the processor is to determine the carrier frequency and pulse repetition frequency (PRF) of received radar signals.
Uptake of a fluorescent l-glucose derivative 2-NBDLG into three-dimensionally accumulating insulinoma cells in a phloretin-sensitive manner (2015)

Of two stereoisomers of glucose, only D- and not L-glucose is abundantly found in nature, being utilized as an essential fuel by most organisms. The uptake of D-glucose into mammalian cells occurs through glucose transporters such as GLUTs, and this process has been effectively monitored by a fluorescent D-glucose derivative 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) at the single cell level. However, since fluorescence is an arbitrary measure, we have developed a fluorescent analog of L-glucose 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-L-glucose (2-NBDLG), as a negative control substrate for more accurately identifying the stereoselectivity of the uptake. Interestingly, a small portion of mouse insulinoma cells MIN6 abundantly took up 2-NBDLG at a late culture stage (≳ 10 days in vitro, DIV) when multi-cellular spheroids exhibiting heterogeneous nuclei were formed, whereas no such uptake was detected at an early culture stage (≲ 6 DIV). The 2-NBDLG uptake was persistently observed in the presence of a GLUT inhibitor cytochalasin B. Neither D- nor L-glucose in 50 mM abolished the uptake. No significant inhibition was detected by inactivating sodium/glucose cotransporters (SGLTs) with Na(+)-free condition. To our surprise, the 2-NBDLG uptake was totally inhibited by phloretin, a broad spectrum inhibitor against transporters/channels including GLUTs and aquaporins. From these, a question might be raised if non-GLUT/non-SGLT pathways participate in the 2-NBDLG uptake into spheroid-forming MIN6 insulinoma. It might also be worthwhile investigating whether 2-NBDLG can be used as a functional probe for detecting cancer, since the nuclear heterogeneity is among critical features of malignancy.
5-Aryloxy substitution enables efficient mechanically triggered release from a synthetically accessible masked 2-furylcarbinol mechanophore (2021)

Polymers that release small molecules in response to mechanical force are attractive materials for a wide variety of applications. Here, we report a new mechanophore platform based on a masked 2-furylcarbinol derivative that incorporates a 5-aryloxy group, which serves as both an electron-rich substituent to accelerate molecular release and the position of polymer attachment proximal to the furan-maleimide junction. The mechanophore is readily synthesized and efficiently releases both phenol and arylamine payloads following mechanical activation.
Adsorptive Separation of Lead and Zinc Ions by Novel Type of Calix[4]arene Carboxylate Resin Immobilized with Polyallylamine (1997)

Abstract Novel type of calix[4]arene carboxylate resin immobilized with polyallylamine has been prepared to investigate the adsorption behavior for lead and zinc ions. It was found that the resin possesses significantly higher separation efficiency for lead away from zinc. In the separation by means of column chromatography, it was confirmed to highly selectively adsorb trace amount of lead ion over large excess amount of zinc ion.
Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors (2004)

Sonic hedgehog (SHH) and fibroblast growth factor 2 (FGF2) can both induce neocortical precursors to express the transcription factor OLIG2 and generate oligodendrocyte progenitors (OLPs) in culture. The activity of FGF2 is unaffected by cyclopamine, which blocks Hedgehog signalling, demonstrating that the FGF pathway to OLP production is Hedgehog independent. Unexpectedly, SHH-mediated OLP induction is blocked by PD173074, a selective inhibitor of FGF receptor (FGFR) tyrosine kinase. SHH activity also depends on mitogen-activated protein kinase (MAPK) but SHH does not itself activate MAPK. Instead, constitutive activity of FGFR maintains a basal level of phosphorylated MAPK that is absolutely required for the OLIG2- and OLP-inducing activities of SHH. Stimulating the MAPK pathway with a retrovirus encoding constitutively active RAS shows that the requirement for MAPK is cell-autonomous, i.e. MAPK is needed together with SHH signalling in the cells that become OLPs.
Marinopyrrole Derivatives as Potential Antibiotic Agents against Methicillin-Resistant Staphylococcus aureus (I) (2012)

Infections caused by drug-resistant pathogens are on the rise. The ongoing spread of methicillin-resistant Staphylococcus aureus (MRSA) strains exemplifies the urgent need for new antibiotics. The marine natural product, marinopyrrole A, was previously shown to have potent antibiotic activity against Gram-positive pathogens, including MRSA. However, its minimum inhibitory concentration (MIC) against MRSA was increased by >500 fold in the presence of 20% human serum, thus greatly limiting therapeutic potential. Here we report our discovery of a novel derivative of marinopyrrole A, designated 1a, featuring a 2-4 fold improved MIC against MRSA and significantly less susceptibility to serum inhibition. Importantly, compound 1a displayed rapid and concentration-dependent killing of MRSA. Compared to the natural product counterpart, compound 1a provides an important natural product based scaffold for further Structure Activity Relationship (SAR) and optimization.
Motion Aware Exposure Bracketing for HDR Video (2015)

Abstract Mobile phones and tablets are rapidly gaining significance as omnipresent image and video capture devices. In this context we present an algorithm that allows such devices to capture high dynamic range (HDR) video. The design of the algorithm was informed by a perceptual study that assesses the relative importance of motion and dynamic range. We found that ghosting artefacts are more visually disturbing than a reduction in dynamic range, even if a comparable number of pixels is affected by each. We incorporated these findings into a real‐time, adaptive metering algorithm that seamlessly adjusts its settings to take exposures that will lead to minimal visual artefacts after recombination into an HDR sequence. It is uniquely suitable for real‐time selection of exposure settings. Finally, we present an off‐line HDR reconstruction algorithm that is matched to the adaptive nature of our real‐time metering approach.
Comparative study on the electrooptical properties of polymer‐dispersed liquid crystal films with different mixtures of monomers and liquid crystals (2011)

Abstract This article deals with the study of polymer‐dispersed liquid crystal (PDLC) films that consisted of microdroplets of liquid crystals (LCs) dispersed in a polymer matrix. The PDLC films were fabricated by the photoinduced phase separation method under room‐temperature conditions. To determine the extent of the effects of the molecular structures and their physical properties of different mixtures of monomers and LCs on the morphology and electrooptical properties of the PDLC films, various mixtures were used. A detailed discussion of the obtained results is given. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011