gebhart/patrepeval huggingface dataset:
Short and Sweet: Evolution of a Small Glycopeptide from a Bladder Disorder to an Anticancer Lead (2009)

Glycopeptides are a class of molecules that comprise two distinct families of biologically important scaffolds, peptides and oligosaccharides, each playing important roles in cellular communication and signaling. Rarely are small, endogenous secreted glycopeptides found that have significant impact on the progression of a specific disease state, but such is the case for the antiproliferative factor (APF) found in the urine and tissue of patients with the poorly understood bladder diseases collectively referred to as interstitial cystitis (IC). APF is a 9-mer peptide containing a sialylated O-linked trisaccharide glycan attached to the N-terminal threonine. APF dramatically inhibits normal bladder cell proliferation and is thought to cause some of the characteristic pathological changes in the bladder of IC patients. Importantly, APF also potently inhibits the growth of certain tumor cells. The details of the cellular receptors to which APF interacts, and the structural features that are critical for its potency are now beginning to unfold. This interesting molecule is a powerful model for the design of new treatments and diagnostic tests for IC, as well as an unprecedented lead agent for novel anticancer drug design.
FR 22. Comparison of three methods for the synchronization of oestrus cycles using prostaglandin F2a in dry multiparous cows and heifers (1997)

The objetive of this study was to evaluate the synchronization effect of estrous cycles in 3 different protocols in 5 different sites. An analogue of the PGF2a was used (Delprostenate) with a fourth of its commercial dose (200 mg).The number of animals were 34, 38, 38; 18, 19, 18; 31, 32, 28; 34, 32, 40; 15, 9, 22 for the 5
experiments and 3 treatments, respectively. Treatment 1(T1) consisted in one intramuscular (i.m) injection of PGF2a 5 days after being started the artificial insemination (AI) (day 0 = heat) in those animals that did not show heat at the moment.In T.2 and T.2 PGF2a was injected twice with an interval of 11 and 15 days respectively. Analysis 1 started when only (T1) or last injection of PGF2a (T2 and 3) was given and it ended 6 days later. In the last protocols (T2 and 3) AI was started 3 days before the second injection of PGF2a took place (Analysis 2).A model that included treatment, experiment and interaction treatment-experiment was used. The dependant variables were H% (heat rate) and NR% (non-return rate). In conclusion, the results obtained showed that T3 using an analogue of the PGF2a (Delprostenate) with a fourth of it commercial dose (200 mg) was similar or better than the other two protocols except in H% in one of the experiments.
Optimization of Medipix-2 threshold masks for spectroscopic X-ray imaging (2008)

Spectroscopic X-ray imaging enhances image contrast and provides advanced object information due to energy resolution. The Medipix-2 is a photon counting semiconductor detector and features two energy thresholds for spectroscopic imaging. The aim of this study is to present the development of optimized threshold adjustment masks with small energy windows of about 3 keV and to demonstrate spectroscopic X-ray imaging using the example of an integrated circuit.
Influence of Gas Nitriding on Rolling Contact Fatigue: Application on Alloyed Steels for Gears (2014)

International audience
Integrating online and offline testing of a switching memory (1998)

A circuit used in a telephone switching unit features several test techniques, including BIST, partial scan, and boundary scan. By sharing the same circuitry for both online and offline testing, the design minimizes additional logic while achieving very high fault coverage.
Study on extraction of curcumin from turmeric (2004)

Rude curcumin is extracted from turmeric with 75% ethanol. Rude product is refined, respectively by precipitation and adsorption separation, and the curcumin with high purity is obtained. In the experiment of adsorption separation, the effect of different composition of ethanol on the elution of curcumin was discussed, and its is found that the optimum composition is 90% ethanol. In the experiment of precipitation, the effect of pH on precipitation of curcumin was investigated, and it is found that pH=7.0 is suitable for precipitation. The experimental results show that the purity of the product obtained by precipitation is higher than by adsorption separation, but the recovery rate for precipitation is lower than for adsorption separation, Adsorption separation is more suitable for industrial application than precipitation.
Evaluation of Microwave-Induced Air-Plasma as an Excitation Source (1985)

A single-electrode atmospheric pressure microwave discharge air-plasma is reported. Fundamental characteristics, such as the effects of microwave power, auxiliary air flow, and nebulizer air flow on emission intensity, detection limits, and dynamic ranges for twelve elements and several interference experiments are reported. The plasma temperature is found to be about 4700°K. This simple system can be applied to the spectrochemical analysis of solution samples. The results with the use of this system to determine calcium, sodium, and potassium in SRM-1566 (oyster tissue) and SRM-92 (low-boron glass) show excellent agreement with the NBSs certified values.
Transthyretin Deposition in Familial Amyloidotic Polyneuropathy (2012)

The subject of the review is on hereditary transthyretin (TTR) amyloidosis which is a genetically transmitted disease that results from a mutation in the gene encoding the plasma TTR protein. TTR is a transport protein for thyroid hormones and vitamin A and is predominantly synthesised in the liver. Although originally regarded as a rare disease, it is now becoming clear that many kindreds exist worldwide. Current knowledge and hypotheses on the biology of TTR, mechanisms of TTR amyloid fibril formation, phenotypic consequences TTR amyloid deposition and pre-clinical models of the disease will be discussed.
Progesterone Inhibits the Induction of Aromatase Activity in Rat Granulosa Cells in Vitro1 (1983)

The development of ovulatory follicles is suppressed during reproductive states with high circulating levels of progesterone. We have investigated the effects of progesterone on estradiol secretion by rat granulosa cells in vitro to determine if progesterone has direct effects on follicular aromatization. Relatively undifferentiated granulosa cells were obtained from hypophysectomized (HPX), diethylstilbestrol-treated immature rats and differentiated granulosa cells were obtained from preovulatory follicles on the morning of proestrus. Progesterone suppressed, in a dose-dependent fashion, the accumulation of estradiol when HPX or proestrous cells were cultured with follicle-stimulating hormone (FSH) (300 ng/ml) and testosterone (0.5 microM), but granulosa cells from proestrous rats were less sensitive to the inhibitory effects of progesterone. When aromatase was first induced in cells from HPX rats by culturing them for 1, 2, or 3 days with FSH, the cells were less susceptible to the inhibitory effects of progesterone during the subsequent 3 days of culture. The inhibitory effects of progesterone on estradiol secretion appeared irreversible when cells were exposed to progesterone for longer than 1 day. The effects of progesterone on HPX granulosa cells were specific since the progesterone precursor, pregnenolone, was as inhibitory as progesterone, while the progesterone metabolite, 17 alpha-hydroxyprogesterone, had no effect. When granulosa cells from proestrous follicles were cultured with testosterone and graded doses of progesterone, a slight inhibition of estradiol production occurred. This inhibition was much less than that observed when FSH was present. Therefore, the inhibitory effects of progesterone are exerted primarily on the induction of aromatase by FSH, rather than on the functioning of existing aromatase. Whole proestrous follicles were also cultured with graded doses of progesterone in the presence or absence of FSH and/or testosterone. In those experiments progesterone increased estradiol on the first day of culture, but inhibited the effects of FSH in maintaining estradiol secretion later in culture. These experiments have shown that progesterone exerts a specific and irreversible inhibitory effect on estradiol production by granulosa cells. Less differentiated granulosa cells appear to be more sensitive to the inhibitory effects of progesterone. These results suggest that in vivo progesterone may directly suppress development of ovulatory follicles by inhibiting aromatase in granulosa cells of developing follicles.
Experimental Measurements of Mechanical Properties of PUR Foam Used for Testing Medical Devices and Instruments Depending on Temperature, Density and Strain Rate (2020)

Rigid polyurethane (PUR) foam is products used as a biomedical material for medical device testing. Thermal stability is a very important parameter for evaluating the feasibility of use for testing surgical instrument load during drilling. This work aimed to perform experimental measurements to determine the dependence of the mechanical properties of a certified PUR on temperature, strain rate and density. Experimental measurements were realised for three types of the PUR samples with different density 10, 25 and 40 pounds per cubic foot. The samples were characterised in terms of their mechanical properties evaluated from tensile and compression tests at temperatures of 25 °C, 90 °C and 155 °C. Furthermore, the structures of the samples were characterised using optical microscope, their thermal properties were characterised by thermogravimetric analysis, and their density and stiffness with the effect of temperature was monitored. The results show that it is optimal not only for mechanical testing but also for testing surgical instruments that generate heat during machining. On the basis of experimental measurements and evaluations of the obtained values, the tested materials are suitable for mechanical testing of medical devices. At the same time, this material is also suitable for testing surgical instruments that generate heat during machining.
WHY SAME-SEX MARRIAGE IS UNJUST (2016)

Proponents of same-sex marriage often defend their view by appealing to the concept of justice. But a significant argument from justice against same-sex marriage can be made also, as follows. Heterosexual union has special social value because it is the indispensable means by which humans come into existence. What has special social value deserves special recognition and sanction. Civil ordinances that recognize same-sex marriage as comparable to heterosexual marriage constitute a rejection of the special social value of heterosexual unions, and to deny such special social value is unjust.
The Incidence of Post‐operative Urinary Tract Infection in Patients with Ureteric Stents (1990)

Despite the many advantages provided by the ureteric stent, it produces a foreign body reaction and increases the risk of infection. We undertook a study on the rate of infection in a group of paediatric patients with ureteric stents; 40 ureteric stents, 6 to 9 F, were used in 36 children undergoing the following procedures: 18 pyeloplasties, 20 antireflux ureteric reimplantation and 2 uretero-rectal anastomoses. Only patients with sterile urine pre-operatively were included in the study. All received antibiotic cover in the post-operative period. Positive urine cultures were found in only 3 patients (7.5%). In spite of this low incidence, the urine specimens collected from all children 1 month after removal of the stent showed a much higher incidence of infection. It was concluded that ureteric stenting is a safe procedure with a low rate of infection provided that antibiotic cover is given.
Avaliação do uso de suplemento esportivo e conhecimento de nutrição por praticantes de ciclismo indoor em academias de cinco regiões de Belo Horizonte-MG (2011)

Introduction: The search for the best fitness has led many people to the practice of various forms of physical exercise at gyms, indoor cycling among them, along with the consumption of supplements. Objective: To evaluate the consumption of supplements by practitioners of spinning and who indicated their consumption, as well as knowledge of nutrition in five academies of Belo Horizonte. Materials and Methods: A descriptive study was performed with 75 practitioners from spinning. We used a self-administered questionnaire.The selection of the academies and students was random. Results and Discussion: 9.3% of the sample used supplement. Of these, all used the protein and the indication for use arose primarily from a dietitian, with the exception of the east. The low consumption of supplements can be explained by the low duration of exercise. With regard to knowledge of nutrition was observed that the academy was the center that showed errors in the citation of the sources of carbohydrates and fats. In relation to sources of protein, the North was the region with more errors, and these regions with lower nutritional counseling. Conclusion: It is important the presence of a dietitian working in these regions to promote the nutritional knowledge needed, and allows the use of supplements, when necessary, be done with adequate technical support.
Identification of microtubule‐associated proteins (MAPs) in <i>Xenopus</i> oocyte (1985)

Microtubules were isolated from prophase-blocked oocytes of Xenopus laevis with the use of the anti-tumor drug taxol. In addition to tubulin, 5 microtubule-associated proteins (MAPs) were characterized. Among them, 2 high molecular mass proteins (200-300 kDa) are phosphorylated in ovo. The oocyte MAP extract promotes the assembly of rat brain 6 S purified tubulin.
Pancreatic Cancer: Recent Advances in Nanoformulation-Based Therapies (2018)

Pancreatic cancer is the fourth leading cause of death in the United States and has a 5-year life expectancy of ~8%. Currently, only a few drugs have been approved by the United States Food and Drug Administration for pancreatic cancer treatment. Despite available drug therapy and ongoing clinical investigations, the high prevalence and mortality associated with pancreatic cancer mean that there is an unmet chemopreventive and therapeutic need. From ongoing studies with various novel formulations, it is evident that the development of smart drug delivery systems will improve delivery of drug cargo to the pancreatic target site to ensure and enhance the therapeutic/chemoprevention efficacy of existing drugs and newly designed drugs in the future. With this in view, nanotechnology is emerging as a promising avenue to enhance drug delivery to the pancreas via both passive and active targeting mechanisms. Research in this field has grown extensively over the past decade, as is evident from available scientific literature. This review summarizes the recent advances that have brought nanotechnology-based formulations to the forefront of pancreatic cancer treatment.
Increasing Plasma Membrane Phosphatidylinositol(4,5)Bisphosphate Biosynthesis Increases Phosphoinositide Metabolism in<i>Nicotiana tabacum</i> (2007)

A genetic approach was used to increase phosphatidylinositol(4,5)bisphosphate [PtdIns(4,5)P2] biosynthesis and test the hypothesis that PtdInsP kinase (PIPK) is flux limiting in the plant phosphoinositide (PI) pathway. Expressing human PIPKIalpha in tobacco (Nicotiana tabacum) cells increased plasma membrane PtdIns(4,5)P2 100-fold. In vivo studies revealed that the rate of 32Pi incorporation into whole-cell PtdIns(4,5)P2 increased >12-fold, and the ratio of [3H]PtdInsP2 to [3H]PtdInsP increased 6-fold, but PtdInsP levels did not decrease, indicating that PtdInsP biosynthesis was not limiting. Both [3H]inositol trisphosphate and [3H]inositol hexakisphosphate increased 3-and 1.5-fold, respectively, in the transgenic lines after 18 h of labeling. The inositol(1,4,5)trisphosphate [Ins(1,4,5)P3] binding assay showed that total cellular Ins(1,4,5)P3/g fresh weight was >40-fold higher in transgenic tobacco lines; however, even with this high steady state level of Ins(1,4,5)P3, the pathway was not saturated. Stimulating transgenic cells with hyperosmotic stress led to another 2-fold increase, suggesting that the transgenic cells were in a constant state of PI stimulation. Furthermore, expressing Hs PIPKIalpha increased sugar use and oxygen uptake. Our results demonstrate that PIPK is flux limiting and that this high rate of PI metabolism increased the energy demands in these cells.
High-density lipoprotein as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells (2005)

rHDL-ACM complex keeps the basic physical and biological binding properties of native HDL and shows a preferential cytotoxicity for SMMC-7721 hepatoma to normal L02 hepatocytes. HDL is a potential carrier for delivering lipophilic antitumoral drug to hepatoma cells.
A Wieferich Prime Search up to 6.7 × 10 15 (2011)

A Wieferich prime is a prime p such that 2p-1 ≡ 1 (mod p2). Despite several intensive searches, only two Wieferich primes are known: p = 1093 and p = 3511. This paper describes a new search algorithm for Wieferich primes using double-precision Montgomery arithmetic and a memoryless sieve, which runs significantly faster than previously published algorithms, allowing us to report that there are no other Wieferich primes p < 6.7 × 1015. Furthermore, our method allowed for the efficent collection of statistical data on Fermat quotients, leading to a strong empirical confirmation of a conjecture of Crandall, Dilcher, and Pomerance. Our methods proved flexible enough to search for new solutions of ap-1 ≡ 1 (mod p2) for other small values of a, and to extend the search for Fibonacci-Wieferich primes. We conclude, among other things, that there are no Fibonacci-Wieferich primes less than p < 9.7 × 1014.
Time-kill curves for a semisynthetic glycopeptide, LY333328, against vancomycin-susceptible and vancomycin-resistant Enterococcus faecium strains (1997)

Free access1 June 1997 Share on Time-kill curves for a semisynthetic glycopeptide, LY333328, against vancomycin-susceptible and vancomycin-resistant Enterococcus faecium strainsAuthors: S A Zelenitsky, J A Karlowsky, G G Zhanel, D J Hoban, T NicasAuthors Info & AffiliationsDOI: https://doi.org/10.1128/AAC.41.6.1407 PDF/EPUB
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells (2003)

Eradication of HIV infection depends on the elimination of a small, but stable population of latently infected T cells. After the discontinuation of therapy, activation of latent virus can rekindle infection. To purge this reservoir, it is necessary to define cellular signaling pathways that lead to activation of latent HIV. We used the SCID-hu (Thy/Liv) mouse model of HIV latency to analyze a broad array of T cell-signaling pathways and show in primary, quiescent cells that viral induction depends on the activation of two primary intracellular signaling pathways, protein kinase C or nuclear factor of activated T cells (NF-AT). In contrast, inhibition or activation of other important T cell stimulatory pathways (such as mitogen-activated protein kinase, calcium flux, or histone deacetylation) do not significantly induce virus expression. We found that the activation of NF-kappaB is critical to viral reactivation; however, all pathways that stimulate NF-kappaBdonot reactivate latent virus. Our studies further show that inhibition of NF-kappaB does not prevent activation of HIV by NF-AT, indicating that these pathways can function independently to activate the HIV LTR. Thus, we define several molecular pathways that trigger HIV reactivation from latency and provide evidence that latent HIV infection is maintained by the functional lack of particular transcription factors in quiescent cells.
Digital Storage and Memory (2022)

Storage and memory technologies are changing to support big data applications. This article discusses trends in NVM Express storage, Compute Express Link, and heterogeneous memory as well as object storage with experts, and it gives a view of the future of compute, memory, and storage.
Tissue engineering : applications in maxillofacial surgery and periodontics (1999)

Basic principles of tissue engineering biology of bone healing wound healing and regeneration in a fetal cleft lip model platelet-rich plasma grafting materials in repair and restoration biology and clinical applications of rhBMP-2 studies of the surgical application of osteoconductive and osteoinductive materials distraction osteogenesis distraction osteogenesis in maxillofacial surgery preclinical considerations for use of OP-1 in periodontal regeneration and osseous reconstruction regeneration of the pulp-dentin complex peripheral nerve regeneration cutaneous wound repair and gene transfer periodontal tissue regeneration by polypeptide growth factors and gene transfer periodontal regeneration and localized osseous regeneration in the oral cavity freeze-dried bone allografts in periodontics application of rhbmp-2 to alveolar and periodontal defects.
An Overview: Current Systemic Therapies for Advanced Non-Small Cell Lung Cancer (2011)

The paradigm of empiric treatment for advanced or metastatic non-small cell carcinoma of the lung (A-NSCLC) has been challenged in recent years, with an increasing emphasis on personalizing current therapies and utilizing new therapies that target the drivers of carcinogenesis. As more systemic therapies become available, decisions regarding the optimal type of therapy, timing and duration of treatment are becoming increasingly complex. Clinicians involved in the care of patients with lung cancer may wish to be kept up-to-date regarding the current approaches to treatment. Herein we provide an overview of the current systemic therapies for A-NSCLC, discussing evidence-based approaches to firstline, second-line and maintenance treatment. An outline of the pharmacology of the major classes of active drugs is given, and key evidence is outlined and organized by line of treatment. The characteristics of the target populations for treatment are discussed, along with the optimal combination and timing of therapy. Keywords: Chemotherapy, bevacizumab, EGFR inhibitors, metastatic, pemetrexed, pharmacology, review, non-small cell carcinoma