gebhart/patrepeval huggingface dataset:
Design and Development of a Soft Robotic Back Orthosis (2018)

Chronic back pain is a disorder which affects a large portion of the American population at some time during their lifespan. There are many causes for lower back pain and usually can be an indicator of a serious medical condition. This problem plagues the nation and the world leading to an estimated annual cost for back pain treatment amounts to $50 billion. This problem isn’t isolated to just the United States either, the world at large suffers from back pain and unfortunately modern treatment methods are effective but the technology simply hasn’t progressed in decades. The main drawback appears to be the rigidity of the device, which limits flexibility and comfort. The soft pneumatic actuators of this newfound device have the potential to provide the appropriate applications chronic back pain suffers and post-surgery patients. In this work, the design and development of a soft robotic back orthotic device that has the capability to relieve back pain by assisting patients to fully achieve the upright position and stabilize the lumbosacral spine, is presented. The soft robotic actuators of this device allow the support to be disabled when the patient is in a supported position. Unlike conventional robotic assistive devices, this pneumatically actuated back orthosis provides dynamic support while being lightweight, comfortable, and cost affordable. After testing the device in a laboratory environment, the data overall displays a trend decreasing in EMG activity of the Erector Spinae muscles. This reduced activity leads to a reduction in strain on the patient.
A diverse family of novel peptide toxins from an unusual cone snail, <i>Conus californicus</i> (2010)

Diversity among Conus toxins mirrors the high species diversity in the Indo-Pacific region, and evolution of both is thought to stem from feeding-niche specialization derived from intra-generic competition. This study focuses on Conus californicus, a phylogenetic outlier endemic to the temperate northeast Pacific. Essentially free of congeneric competitors, it preys on a wider variety of organisms than any other cone snail. Using molecular cloning of cDNAs and mass spectrometry, we examined peptides isolated from venom ducts to elucidate the sequences and post-translational modifications of two eight-cysteine toxins (cal12a and cal12b of type 12 framework) that block voltage-gated Na(+) channels. Based on homology of leader sequence and mode of action, these toxins are related to the O-superfamily, but differ significantly from other members of that group. Six of the eight cysteine residues constitute the canonical framework of O-members, but two additional cysteine residues in the N-terminal region define an O+2 classification within the O-superfamily. Fifteen putative variants of Cal12.1 toxins have been identified by mRNAs that differ primarily in two short hypervariable regions and have been grouped into three subtypes (Cal12.1.1-3). This unique modular variation has not been described for other Conus toxins and suggests recombination as a diversity-generating mechanism. We propose that these toxin isoforms show specificity for similar molecular targets (Na(+) channels) in the many species preyed on by C. californicus and that individualistic utilization of specific toxin isoforms may involve control of gene expression.
Biodegradation of Xanthan Gum by <i>Bacillus</i> sp (1982)

Strains tentatively identified as Bacillus sp. were isolated from sewage sludge and soil and shown to elaborate extracellular enzymes that degrade the extracellular polysaccharide (xanthan gum, polysaccharide B-1459) of Xanthomonas campestris NRRL B-1459. Enzyme production by one strain was greatly enhanced when the strain was incubated in a mixed culture. Products of degradation were identified as d-glucuronic acid, d-mannose, pyruvylated mannose, 6-O-acetyl d-mannose, and a (1-->4)-linked glucan. These products correlate with the known structure of the gum. The complexity of the product mixture indicated that the xanthanase was a mixture of carbohydrases. The xanthanase complexes were similar to one another in temperature stability, pH and temperature optima, degree of substrate degradation, and enzymolysis products. Differences in pH stability, salt tolerance, recoverability, and yields of enzyme were observed.
Rapid thermal processing of self-assembling block copolymer thin films (2013)

Self-assembling block copolymers generate nanostructured patterns which are useful for a wide range of applications. In this paper we demonstrate the capability to control the morphology of the self-assembling process of PS-b-PMMA diblock copolymer thin films on unpatterned surfaces by means of fast thermal treatment performed in a rapid thermal processing machine. The methodology involves the use of radiation sources in order to rapidly drive the polymeric film above the glass transition temperature. Highly ordered patterns were obtained for perpendicular-oriented cylindrical and lamellar PS-b-PMMA block copolymers in less than 60 s. This approach offers the unprecedented opportunity to investigate in detail the kinetics of the block copolymer self-assembly during the early stages of the process, providing a much deeper understanding of the chemical and physical phenomena governing these processes.
Coding for tolerance and detection of skew in parallel asynchronous communications (2000)

We provide a new definition for the concept of skew in parallel asynchronous communications introduced by Blaum and Bruck (1993). The new definition extends and strengthens previously known results on skew. We give necessary and sufficient conditions for codes that can tolerate a certain amount of skew under the new definition. We also extend the results to codes that can tolerate a certain amount of skew and detect a larger amount of skew when the tolerating threshold is exceeded.
High‐resolution <sup>1</sup>H NMR spectroscopy in rat liver using magic angle turning at a 1 Hz spinning rate (2002)

It is demonstrated that a high-resolution (1)H NMR spectrum of excised rat liver can be obtained using the technique of magic angle turning (MAT) at a sample spinning rate of 1 Hz. A variant of the phase-corrected MAT (PHORMAT) pulse sequence that includes a water suppression segment was developed for the investigation. The spectral resolution achieved with PHORMAT approaches that obtained from a standard magic angle spinning (MAS) experiment at a spinning rate of several kHz. With such ultra-slow spinning, tissue and cell damage associated with the standard MAS experiment is minimized or eliminated. The technique is potentially useful for obtaining high-resolution (1)H spectra in live animals.
Structural modification study of bis(substituted aminoalkylamino)anthraquinones. An evaluation of the relationship of the [2-[(2-hydroxyethyl)amino]ethyl]amino side chain with antineoplastic activity (1979)

Several anthraquinones containing the [2-[(2-hydroxyethyl)amino]ethyl]amino, the [2-(dimethylamino)ethyl]amino, and the 2-(dimethylamino)ethoxy groups were prepared. Preparation of a lucanthone analogue, a 7-chloroquinoline derivative, and derivatives of naphthoquinones containing the [2-[(2-hydroxyethyl)amino]ethyl]amino side chain and related amino-substituted side chains was also conducted. It was found that the antineoplastic activity of anthraquinones containing the [2-[(2-hydroxyethyl)amino]ethyl]amino side chain is superior to those containing the tertiary amino side chain. However, the presence of the [2-[(2-hydroxyethyl)amino]ethyl]amino chain is an important, but not a sufficient, factor for good antineoplastic activity, as indicated by the lack of significant biological activity of other ring systems containing this side chain.
Photonic Multitasking Interleaved Si Nanoantenna Phased Array (2016)

Metasurfaces provide unprecedented control over light propagation by imparting local, space-variant phase changes on an incident electromagnetic wave. They can improve the performance of conventional optical elements and facilitate the creation of optical components with new functionalities and form factors. Here, we build on knowledge from shared aperture phased array antennas and Si-based gradient metasurfaces to realize various multifunctional metasurfaces capable of achieving multiple distinct functions within a single surface region. As a key point, we demonstrate that interleaving multiple optical elements can be accomplished without reducing the aperture of each subelement. Multifunctional optical elements constructed from Si-based gradient metasurface are realized, including axial and lateral multifocus geometric phase metasurface lenses. We further demonstrate multiwavelength color imaging with a high spatial resolution. Finally, optical imaging functionality with simultaneous color separation has been obtained by using multifunctional metasurfaces, which opens up new opportunities for the field of advanced imaging and display.
Lightweight Refresh Method for PCM-based Neuromorphic Circuits (2018)

Phase change memory (PCM) is being explored as a synaptic nanodevice for scalable and low-power neuromorphic circuits. We present a novel and lightweight method to refresh PCM cells after they saturate at their maximum conductance during the learning process. Our learning system is an event-based Restricted Boltzmann Machine with Spike Time Dependent Plasticity update rule using a modified contrastive divergence algorithm. By using our event-based neuromorphic circuit simulator and the MNIST handwritten digit dataset, we show that our refresh method reduces power consumption by decreasing the number of SET and RESET programming pulses while maintaining high learning accuracy.
Optical quality of tilted spherical mirror unstable resonators (1979)

A new class of resonators has recently been proposed which has the property of having different magnifications Mx and My in orthogonal directions perpendicular to the propagation direction; the most interesting cases are those with collimated output analagous to conventional confocal unstable resonators. The designs utilize spherical mirrors which are tilted substantially from the mirror normal. The conventional orientation requires the mirror normal to be along (or very nearly parallel to) the propagation direction. Use of spherical mirrors by this new class of resonators eliminates the difficulties of fabricating mirrors with more complex figures, which would otherwise be required to achieve the desired asymmetric magnification. The critical problem of keeping beam-quality degradation (aberrations) due to mirror tilt within acceptable limits has been examined experimentally and analytically. The results confirm the possibility of achieving acceptable small aberrations for large tilt angles (convex mirror tilt as large as 70 deg, corresponding to 140 deg beam deflection) to operation at infrared wavelengths.
Syntheses and crystal structures of the cinchona alkaloid derivatives used as ligands in the osmium-catalyzed asymmetric dihydroxylation of olefins (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses and crystal structures of the cinchona alkaloid derivatives used as ligands in the osmium-catalyzed asymmetric dihydroxylation of olefinsWilli Amberg, Youssef L. Bennani, Raj K. Chadha, Gerard A. Crispino, William D. Davis, Jens Hartung, Kyu Sung Jeong, Yasukazu Ogino, Tomoyuki Shibata, and K. Barry SharplessCite this: J. Org. Chem. 1993, 58, 4, 844–849Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/jo00056a015https://doi.org/10.1021/jo00056a015research-articleACS PublicationsRequest reuse permissionsArticle Views2415Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
UFP-112 a Potent and Long-Lasting Agonist Selective for the Nociceptin/Orphanin FQ Receptor (2010)

Nociceptin/orphanin FQ (N/OFQ) controls several biological functions via selective activation of the N/OFQ peptide receptor (NOP). [(pF)Phe(4) Aib(7) Arg(14) Lys(15) ]N/OFQ-NH(2) (UFP-112) is an NOP receptor ligand designed using a combination of several chemical modifications in the same peptide sequence that increase NOP receptor affinity/potency and/or reduce susceptibility to enzymatic degradation. In the present review article, we summarize data from the literature and present original findings on the in vitro and in vivo pharmacological features of UFP-112. Moreover, important biological actions and possible therapeutic indications of NOP receptor agonists are discussed based on the results obtained with UFP-112 and compared with other peptide and nonpeptide NOP receptor ligands.
Rates of Ammonia Absorption and Release in Calcium Chloride (2018)

After synthesis, ammonia can be selectively absorbed by calcium chloride; nitrogen and hydrogen are not absorbed. The kinetics of release seem to be diffusion controlled. The kinetics of absorption are consistent with a first-order reaction after an initial period of a higher-order reaction, which may indicate a nucleation event. At 225 °C, both absorption and release show half-lives of around 10 min if the ammonia partial pressure is swung from 2 to 1 bar, which allows design of an absorber for the periodic separation of ammonia. When this absorber replaces the ammonia condenser in a conventional ammonia synthesis, the ammonia production at low pressure can have the same rate as the conventional process operating at higher pressure.
Motion vector refinement for high-performance transcoding (1999)

In transcoding, simply reusing the motion vectors extracted from an incoming video bit stream may not result in the best quality. In this paper, we show that the incoming motion vectors become nonoptimal due to the reconstruction errors. To achieve the best video quality possible, a new motion estimation should be performed in the transcoder. We propose a fast-search adaptive motion vector refinement scheme that is capable of providing video quality comparable to that can be achieved by performing a new full-scale motion estimation but with much less computation. We discuss the case when some incoming frames are dropped for frame-rate conversions, and propose motion vector composition method to compose a motion vector from the incoming motion vectors. The composed motion vector can also be refined using the proposed motion vector refinement scheme to achieve better results.
Field-induced refractive index variation in the dark conglomerate phase for polarization-independent switchable liquid crystal lenses (2014)

Liquid crystal lenses are an emerging technology that can provide variable focal power in response to applied voltage. Many designs for liquid-crystal-based lenses are polarization dependent, so that 50% of light is not focused as required, making polarization-independent technologies very attractive. Recently, the dark conglomerate (DC) phase, which is an optically isotropic liquid crystalline state, has been shown to exhibit a large change in refractive index in response to an applied electric field (Δn=0.04). This paper describes computational modeling of the electrostatic solutions for two different types of 100 μm diameter liquid crystal lenses, which include the DC phase, demonstrating that it shows great potential for efficient isotropic optical switching in lenses. A feature of the field dependence of the refractive index change in the DC phase is that it is approximately linear in a certain range, leading to the prediction of excellent optical quality for driving fields in this regime. Interestingly, a simulated microlens is shown to exhibit two modes of operation: a positive lens based upon a uniform bulk change in refractive index at high voltages, and a negative lens resulting from the induction of a gradient index effect at intermediate voltages.
A Heterodimeric Antibody Fragment for Passive Immunotherapy Against Norovirus Infection (2020)

Human noroviruses cause an estimated 685 million infections and 200 000 deaths annually worldwide. Although vaccines against GII.4 and GI.1 genotypes are under development, no information is available regarding vaccines or monoclonal antibodies to other noroviral genotypes. Here, we developed 2 variable-domain llama heavy-chain antibody fragment (VHHs) clones, 7C6 and 1E4, against GII.4 and GII.17 human noroviruses, respectively. Although 7C6 cross-reacted with virus-like particles (VLPs) of GII.17, GII.6, GII.3, and GII.4, it neutralized only GII.4 norovirus. In contrast, 1E4 reacted with and neutralized only GII.17 VLPs. Both VHHs blocked VLP binding to human induced pluripotent stem cell-derived intestinal epithelial cells and carbohydrate attachment factors. Using these 2 VHHs, we produced a heterodimeric VHH fragment that neutralized both GII.4 and GII.17 noroviruses. Because VHH fragments are heat- and acid-stable recombinant monoclonal antibodies, the heterodimer likely will be useful for oral immunotherapy and prophylaxis against GII.4 and GII.17 noroviruses in young, elderly, or immunocompromised persons.
Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones (1979)

The condensation of alkylenediamines with quinizarin or with 2,3-dihydro-1,4,5,8-tetrahydroxy-9,10-anthracenedione, followed by oxidation, gave 1,4-bis[aminoalkyl)amino]-9,10-anthracenediones. Some of these compounds and their 2,3-dihydro derivatives were markedly active against both leukemias and solid tumors in mice. Activity was maximal with 5,8-dihydroxylation and 1,4-bis[(2-aminoethyl)amino] substitution, in which the terminal nitrogen atoms were either unsubstituted (compound 50) or carried 2-hydroxyethyl groups (compound 40), indicating the importance of hydrophilicity. Against B-16 melanoma, 50 gave greater than 433% increase in median life span (ILS) with 7/10 80-day survivors. Against P-388 leukemia, 40 gave greater than 500% ILS with 4/5.60-day survivors; its efficacy and therapeutic index equaled or surpassed those of adriamycin, cyclophosphamide, daunorubicin, methotrexate, or 5-fluorouracil. Against L-1210 leukemia, B-16 melanoma, and colon tumor 26, 40 was generally as effective or more effective than adriamycin and is now undergoing preclinical toxicological evaluation.
Synthesis, characterization, and anticancer activities of the first platinum complexes from sucrose (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, characterization, and anticancer activities of the first platinum complexes from sucroseNavzer D. Sachinvala, Hong Chen, Walter P. Niemczura, Eiichi Furusawa, Roger E. Cramer, John J. Rupp, and Iraj GanjianCite this: J. Med. Chem. 1993, 36, 12, 1791–1795Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jm00064a013https://doi.org/10.1021/jm00064a013research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Development and Evaluation of Ceramic Components for a Gas Turbine (2006)

An 8000 kW class Hybrid Gas Turbine (HGT) project, administered by the New Energy and Industrial Technology Development Organization (NEDO), was completed in March 2004. The targets of this project were improvement in thermal efficiency and output power by using ceramic components, and early commercialization of the gas turbine system. The ceramic components were used for stationary parts subjected to high temperature. It became clear that silicon nitride material showed significant recession under combustion gas. Kyocera and Central Research Institute of Electric Power Industry developed new EBCs to suppress this recession. These EBCs were evaluated by exposure test, heat cycle test and actual HGT engine test. One of the EBCs showed slight defects after the actual engine tests. However, all EBCs showed high corrosion resistance and good adhesion. It was confirmed that the all EBCs worked effectively.
Compressed domain video compositing with HEVC (2015)

Video compositing such as blending of user interfaces or advertisements on top of video content is used in many applications. Compositing is usually carried out in the pixel domain either after decoding on the end device or based on transcoding before or during transport, e.g. on cloud resources. This paper proposes a novel method to create a composition of several coded input videos in the compressed domain, i.e. without performing entropy coding at runtime. The method entails merging of input video bitstreams into a single output video bitstream and insertion of pre-encoded inter-predicted composition pictures. Such a lightweight approach is computationally much less demanding than transcoding-based compositing and can be beneficial for service scalability. This paper explores the coding performance of the proposed method though experiments with the composition of a transparent ticker overlay on top of video sequences. The proposed method is reported to outperform transcoding-based pixel domain compositing in rate distortion and quality.