gebhart/patrepeval huggingface dataset:
Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems (1979)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
The Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer (2011)

It has been shown that Bc2 profiles might be useful in clinical practice to improve BC diagnosis. However none of the proteomics reach reasonable AUC values for the discrimination of the BC. Additional confirmation in larger and similarly-designed prospective studies is needed to consider of the efficacy of Bc1 and Bc2 in early diagnosis of the BC.
Laterally excited bulk wave resonators (XBARs) based on thin Lithium Niobate platelet for 5GHz and 13 GHz filters (2019)

In a free ZY-LiNbO3 400nm thick platelet, narrow electrodes (500nm wide) placed periodically with a pitch of few micrometers can eXcite standing Bulk Acoustic shear wave Resonances (XBARs), by means of lateral electric field parallel to crystalline Y- axis. The resonance frequency of around 4.8GHz and 13.6GHz are suitable for development of RF filters. The XBARs 3rd, 5th and even 9th harmonics were observed up to 38 GHz.
Eddy currents: theory and applications (1992)

The theory and applications of eddy currents induced in conducting materials by time-varying magnetic fields are reviewed. The mathematical methods employed in solving the relevant problems are presented. Both analytical and numerical methods are described. Applications based on effects arising from eddy currents are discussed in detail. These applications are to magnetic levitation, electromagnetic launching, hyperthermia treatment of cancer, and nondestructive testing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mammalian Cdc42 Is a Brefeldin A-sensitive Component of the Golgi Apparatus (1996)

In this study, we have used immunocytochemical and fractionation approaches to provide a description of the localization of the mammalian Cdc42 protein (designated Cdc42Hs) in vivo. A specific anti-peptide antibody was generated against the C-terminal region of Cdc42Hs. Using affinity-purified preparations of this antibody in indirect immunofluorescence experiments, Cdc42Hs was found to be localized to the Golgi apparatus. Similar to the well-characterized non-clathrin coat proteins ADP-ribosylation factor (ARF) and beta-COP, the perinuclear clustering of Cdc42Hs is rapidly dispersed upon exposure of the cells to the drug brefeldin A, suggesting that it too may play a role in the processes of intracellular lipid and protein transport. Employing cell lines possessing inducible forms of ARF, we demonstrate here a tight coupling of the nucleotide-bound state of ARF and the subcellular localization of Cdc42Hs. Specifically, the expression of wild-type ARF had no effect on the brefeldin A sensitivity of Cdc42Hs while, as is the case for ARF and beta-COP, expression of a GTPase-deficient form of ARF (ARF(Q71L)) renders these Golgi-localized proteins resistant to brefeldin A treatment (; ). Moreover, the induced expression of a mutant form of ARF with a low affinity for nucleotide resulted in constitutive redistribution of Cdc42Hs in the absence of brefeldin A treatment. These results suggest that Cdc42Hs may play a role in cell morphogenesis by acting on targets in the Golgi that direct polarized growth at the plasma membrane.
Urinary and Serum Biomarkers after Cardiac Catheterization in Diabetic Patients with Stable Angina and without Severe Chronic Kidney Disease (2009)

CIN was similarly prevalent in both diabetic and non-diabetic patients undergoing cardiac catheterization. NGAL seems to be a potential early marker for nephrotoxicity and predictor of contrast nephropathy. It is particularly important in the upcoming setting of short-time hospitalizations for cardiac catheterization.
D’un possible à dire… Une orientation dans l’enseignement de Jacques Lacan (2000)

Sur les pas de Freud, dont l’un autour du jeu du langage1, Jacques Lacan a souligné le statut particulier de l’équivoque. Elle permet le plaisir partagé d’un sens possible, elle en marque aussi la limite et laisse un reste irréductible au sens. Je tenterai de déplier cette équivoque entre possible et impossible, elle est au cœur de l’enseignement de Lacan et au cœur de l’expérience analytique. La contingence d’une rencontre, puis l’analyse, ont ouvert pour moi la voie de cet enseignement qui tend à cerner le plus difficile à penser auquel chacun est confronté. Le passage de Freud à Lacan se trouve à cette limite du dire. Il me semble que là se trouve aussi un des points d’origine de l’invention par Alain-Noël Henri de la Formation à Partir de la Pratique. Depuis l’expérience du réel, de ceux qui s’en approchent au plus près, il a construit l’offre qu’ils en dégagent un savoir à la fois particulier et transmissible. Comment ce savoir se noue-t-il à la découverte freudienne telle que Lacan en dessine les termes ? Je choisirai ici ceux de l’imaginaire, du symbolique et du réel en marquant la limite que comporte chacun, la part d’impossible, le point de vide qui appelle et permet un nouage. Nous suivrons donc ce fil, un parmi d’autres pour nous orienter dans l’enseignement de Lacan en repérant ses différentes élaborations du stade du miroir, en dégageant les avancées qu’il permet et leurs conséquences dans la pratique. Le travail d’un enfant nous enseignera de façon centrale par
Antioxidant and antimicrobial activities of essential oil and extracts of fennel (<i>Foeniculum vulgare </i>Mill.) seeds from Pakistan (2009)

Abstract The present study was conducted to examine the antioxidant and antimicrobial activities of essential oil, methanol and ethanol extracts of fennel ( Foeniculum vulgare Mill.) seeds native to Pakistan. The seed essential oil and extract yields from fennel seeds were found to be 2.81 and 6.21–15.63% w/w, respectively. GC and GC–MS analysis of the fennel essential oil revealed the presence of 23 compounds, with trans ‐anethol (69.87%), fenchone (10.23%), estragole (5.45%) and limonene (5.10%) as the major components. The fennel seed extracts contained appreciable levels of total phenolic contents (627.21–967.50 GAE, mg/100 g) and total flavonoid contents (374.88–681.96 CE, mg/100 g). Fennel essential oil and extracts also exhibited good DPPH radical scavenging activity, showing IC 50 32.32 and 23.61–26.75 µg/ml, and inhibition of peroxidation 45.05 and 48.80–70.35%, respectively. Of the fennel essential oil and solvent extracts tested, 80% ethanol extract exhibited the maximum antioxidant activity, whereas the essential oil showed appreciable antimicrobial activity against selected strains of bacteria and pathogenic fungi. The results of the present investigation demonstrated significant ( p < 0.05) variations in the antioxidant and antimicrobial activities of fennel essential oil and extracts. Copyright © 2009 John Wiley & Sons, Ltd.
A Survey on Resale of Automobiles Using Emerging Technology: Blockchain (2021)

Block chain technology has been encircled with multiple growing industries, includes: healthcare, Banks, hospitality, travels, CPG and Retail. The salient features of Blockchain being decentralized and transparent has led it be used in digital recording of events in day to day life. Automobile sale is one such event where there is constant growth in the figure, in which re-sale being a major part. The Paper work is emphasized more in transferring the ownership in resale of automobiles and is complicated. The reliable and convenient services brought by Blockchain efficiently overcome the challenges in resale of automobiles in current scenario. Blockchain has already made its success impact in many industries, the unique challenges in automobile resale is a topic we need to bring a light on.
Schemes for equalisation of communication channels with nonlinear impairments (1995)

Two novel techniques are described for equalisation of nonlinear intersymbol interference. One is a symbol-by-symbol-type technique and is built around a conventional decision-feedback equaliser by embedding a neural radial basis-function network before the slicer. The other is a maximum-likelihood method exploiting the classification nature of an equaliser. A Viterbi-minimisation approach is employed which circumvents the need for an explicit channel estimation.
Indoor Positioning System Using Digital Audio Watermarking (2011)

Recently, a number of location-based services such as navigation and mobile advertising have been proposed. Such services require real-time user positions. Since a global positioning system (GPS), which is one of the most well-known techniques for real-time positioning, is unsuitable for indoor uses due to unavailability of GPS signals, many indoor positioning systems (IPSs) using WLAN, radio frequency identification tags, and so forth have been proposed. However, most of them suffer from high installation costs. In this paper, we propose a novel IPS for real-time positioning that utilizes a digital audio watermarking technique. The proposed IPS first embeds watermarks into an audio signal to generate watermarked signals, each of which is then emitted from a corresponding speaker installed in a target environment. A user of the proposed IPS receives the watermarked signals with a mobile device equipped with a microphone, and the watermarks are detected in the received signal. For positioning, we model various effects upon watermarks due to propagation in the air, i.e., delays, attenuation, and diffraction. The model enables the proposed IPS to accurately locate the user based on the watermarks detected in the received signal. The proposed IPS can be easily deployed with a low installation cost because the IPS can work with off-the-shelf speakers that have been already installed in most of the indoor environments such as department stores, amusement arcades, and airports. We experimentally evaluate the accuracy of positioning and show that the proposed IPS locates the user in a 6m by 7.5m room with root mean squared error of 2.25m on average. The results also demonstrate the potential capability of real-time positioning with the proposed IPS.
On-demand fingerprint selection for 802.11-based positioning systems (2008)

Fingerprinting is a popular technology for 802.11-based positioning systems: Radio characteristics from different access points are measured at various positions and stored in a database. The database is copied to all mobile devices, and in case that a position estimate is needed, the device compares its currently measured radio characteristics with all the database entries. In this paper, we present two on-demand fingerprint selection algorithms to avoid the cumbersome and time-consuming approach of manually copying all fingerprints. Our algorithms only request those fingerprints from the database that are currently required to compute a position. The two algorithms differ in the way they shape the region for which fingerprints are requested. On-demand selection also allows storage-restricted mobile devices to utilize the positioning system. We carefully evaluate our algorithms in a real-world experiment. The results show that our algorithms do not harm the position accuracy of the positioning system. In addition, we analyze the space requirements of our algorithms and show that the typical constraints of mobile devices are met.
Head and eye gaze dynamics during visual attention shifts in complex environments (2012)

The dynamics of overt visual attention shifts evoke certain patterns of responses in eye and head movements. In this work, we detail novel findings regarding the interaction of eye gaze and head pose under various attention-switching conditions in complex environments and safety critical tasks such as driving. In particular, we find that sudden, bottom-up visual cues in the periphery evoke a different pattern of eye-head movement latencies as opposed to those during top-down, task-oriented attention shifts. In laboratory vehicle simulator experiments, a unique and significant (p < 0.05) pattern of preparatory head motions, prior to the gaze saccade, emerges in the top-down case. This finding is validated in qualitative analysis of naturalistic real-world driving data. These results demonstrate that measurements of eye-head dynamics are useful data for detecting driver distractions, as well as in classifying human attentive states in time and safety critical tasks.
Same Results, Different Interpretations (2003)

Some of the most promising results with embryonic stem (ES) cells yet published may need a second look. In the past few years, several groups have reported tantalizing progress toward one of the most sought-after goals in this research: the creation of insulin-producing pancreatic β cells, which are damaged in diabetes. But now a research team claims that some of those results might have been misleading.
Four-quadrant CMOS analogue multiplier (1992)

A new four-quadrant CMOS analogue multiplier is presented which is based on the operation of MOS transistors in the saturation region and has simple circuit configuration and good linearity. The simulation result shows that less than 1% distortion can be obtained for input signals of 5.6 V peak to peak and supply voltages of ± 5 V.
O2–06–03: ACU‐193: A candidate therapeutic antibody that selectively targets soluble beta‐amyloid oligomers (2013)

Soluble beta-amyloid oligomers are widely recognized as the key molecular pathogens in Alzheimer's disease. Because these non-fibrillar beta-amyloid assemblies inhibit synaptic function, trigger early memory deficits and initiate neurodegeneration, they represent a highly attractive intervention target for Alzheimer's disease. In this presentation we describe ACU-193, a promising new drug candidate with high binding selectivity for soluble beta-amyloid oligomers, and with potent capability to block their synaptotoxicity. ACU-193 is a humanized, affinity matured IgG2 monoclonal antibody that has been engineered to minimize cellular effector functions and immunogenicity. It binds to soluble beta-amyloid oligomers with low nanomolar affinity, exhibits >500-fold selectivity for soluble beta-amyloid oligomers versus beta-amyloid monomer and fibrillic beta-amyloid, and does not exhibit cross-reactive binding to other proteins. ACU-193 potently blocks synaptic binding of soluble beta-amyloid oligomers in cultured hippocampal neurons (IC 50 = 17 nM), and its efficacy does not diminish in the presence of excess beta-amyloid monomer. In vivo ACU-193 target engagement and behavioral efficacy were demonstrated by administration to Tg-AD mice, which afforded dose-dependent complex formation with soluble beta-amyloid oligomers in brain tissue, reduction in plaque deposition, and significantly reduced abnormal nocturnal hyperactivity. ACU-193 exhibited linear, dose-dependent pharmacokinetics, biodistribution, and brain penetration in mice, rats, dogs, and monkeys, typical of other CNS-directed antibody drugs. ACU-193 has an overall excellent safety profile, and high-yielding, stable cell lines have been established for efficient production. Human dosing is expected to deliver brain levels of ACU-193 >200-fold higher than measured soluble beta-amyloid oligomer levels in AD CSF; thus ACU-193 is expected improve synaptic and cognitive function in AD patients. Biomarker assays to measure the drug-target complex and levels of soluble beta-amyloid oligomers in CSF have been developed to support clinical studies of ACU-193. These assays should allow patient selection and stratification and serve as a companion diagnostic. ACU-193 is expected to deliver acute behavioral benefits and chronic disease modification benefits. Clinical develop plans reflect the availability of biomarker assays and the expectation that behavioral efficacy is achieved relatively quickly. It is anticipated that initial evidence for efficacy will be obtained in a phase Ib study of relatively short duration and cost.
Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study (2014)

MDSCs are present among RA SF cells that are commonly regarded as inflammatory neutrophils. Our results suggest that the presence of neutrophil-like MDSCs in the SF is likely beneficial, as these cells have the ability to limit the expansion of joint-infiltrating T cells in RA.
Design And Development Of A Transportable Image Processing And Gis System (1987)

Over the past several years, the authors have been involved in the development of the ERDAS image processing and GIS system, which has been ported to more than half a dozen different computers, ranging from an Z80 based microcomputer to large multiuser VAX/VMS installations. In this process differences in compilers, operating system capabilities and computer architecture has been overcome to provide a system which is uniform in appearance to the user as well as to the programmer. Identifying the functions needed to implement the system and developing these in a computer independent manner has made this process possible.
Policy Specification and Enforcement for Detection of Security Violations in a Mail Service (2006)

The paper presents a policy-based approach to detect security violations by enforcing security policy at run-time for providing secure email service. As email service usage is increasing day by day, hackers or attackers are also playing a vital role to destruct email service and even to crash the email server. Due to this, it is a challenging task today to the system administrators to provide secure email service. In this paper, security policy is defined at operating system level, mail application level and network infrastructure level. A policy at system level specifies mandatory usage profile, usages of system sensitive resources such as file system objects, processes, system memory and inter process communication objects. Policies for mail application are defined with sensitive files/directories and parameters, which have impact in delivering a service. Policies for network are defined for controlling inbound and outbound traffic, specifying demilitarized zone, denying misuse of public IP and detecting suspicious network activity. The proposed system architecture supports the layered approach in policy enforcement, proactive defensive mechanism against security violations and scope for new policy discovery. The approach is prototyped on Linux-2.4.21-4 and have built rules for squirrel mail version 1.4.5 to detect security violations in a mail service at run-time.
Elevated macrophage migration inhibitory factor (MIF) levels in the urine of patients with focal glomerular sclerosis (2004)

The pathogenesis of focal glomerular sclerosis (FGS) is poorly understood. Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine released from T cells and macrophages, and is a key molecule in inflammation. To examine further the possible role of MIF in FGS, we measured MIF levels in the urine. The purpose of the present study was to evaluate the involvement of MIF in FGS. Urine samples were obtained from 20 FGS patients. The disease controls included 40 patients with minimal-change nephrotic syndrome (MCNS) and membranous nephropathy (MN). A group of healthy subjects also served as controls. Biopsies were performed in all patients prior to entry to the study. The samples were assayed for MIF protein by a sandwich enzyme-linked immunosorbent assay (ELISA). The levels of MIF in the urine of FGS patients were significantly higher than those of the normal controls and patients with MCNS and MN. In contrast, the levels of urinary MIF (uMIF) in patients with MCNS and MN did not differ significantly from normal values. In the present study, attention also focused on the relationship between uMIF levels and pathological features. Among the patients with FGS, uMIF levels were significantly correlated with the grade of mesangial matrix increase and that of interstitial fibrosis. There was also a significant correlation between uMIF levels and the number of both intraglomerular and interstitial macrophages. Although the underlying mechanisms remain to be determined, our study presents evidence that urinary excretion of MIF is increased in FGS patients with active renal lesions.
Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems (2001)

Thioredoxin (Trx) and glutathione (GSH) systems are considered to be two major redox systems in animal cells. They are reduced by NADPH via Trx reductase (TR) or oxidized GSH (GSSG) reductase and further supply electrons for deoxyribonucleotide synthesis, antioxidant defense, and redox regulation of signal transduction, transcription, cell growth, and apoptosis. We cloned and characterized a pyridine nucleotide disulfide oxidoreductase, Trx and GSSG reductase (TGR), that exhibits specificity for both redox systems. This enzyme contains a selenocysteine residue encoded by the TGA codon. TGR can reduce Trx, GSSG, and a GSH-linked disulfide in in vitro assays. This unusual substrate specificity is achieved by an evolutionary conserved fusion of the TR and glutaredoxin domains. These observations, together with the biochemical probing and molecular modeling of the TGR structure, suggest a mechanism whereby the C-terminal selenotetrapeptide serves a role of a protein-linked GSSG and shuttles electrons from the disulfide center within the TR domain to either the glutaredoxin domain or Trx.
STAT5 Activation Correlates with Erythropoietin Receptor-mediated Erythroid Differentiation of an Erythroleukemia Cell Line (1997)

Interaction between erythropoietin (EPO) and its membrane receptor induces the proliferation and differentiation of erythroid progenitors. EPO has been shown to activate the JAK2-STAT5 pathway in various hematopoietic cell lines, although the physiological role of this pathway is unclear. We have previously shown that epidermal growth factor activates a chimeric receptor bearing the extracellular domain of the epidermal growth factor receptor linked to the cytoplasmic domain of the EPO receptor, resulting in proliferation of interleukin-3-dependent hematopoietic cells and erythroid differentiation (globin synthesis) of EPO-responsive erythroleukemia cells. In the present study, we introduced various deletion and tyrosine to phenylalanine substitution in the cytoplasmic domain of the chimeric receptor and expressed these mutant chimeras in an EPO-responsive erythroleukemia cell line, ELM-I-1. Mutant chimeric receptors retaining either Tyr343 or Tyr401 could activate STAT5, judged by tyrosine-phosphorylation of STAT5 and induction of CIS, a target gene of STAT5. These mutants were able to induce erythroid differentiation. However, a chimeric receptor containing both Y343F and Y401F mutations could not activate STAT5 nor induce erythroid differentiation. Thus, Tyr343 or Tyr401 of the EPO receptor are independently necessary for erythroid differentiation as well as STAT5 activation. Moreover, exogenous expression of dominant-negative STAT5 suppressed EPO-dependent erythroid differentiation. These findings suggest that STAT5 plays an important role in erythroid differentiation through the EPO receptor cytoplasmic domain.