gebhart/patrepeval huggingface dataset:
Medical‐grade acrylic adhesives for skin contact (1992)

Abstract Pressure‐sensitive acrylic adhesives for application to skin are made from 2‐ethylhexyl acrylate, isooctyl acrylate or n ‐butyl acrylate copolymerized with polar functional monomers such as acrylic acid, methacrylic acid, vinyl acetate, methyl acrylate, N ‐vinylcaprolactam, or hydroxyethyl methacrylate. Functional comonomers increase cohesive strength, provide surface polarity, and enhance wear performance. Tack, adhesion to skin, adhesive transfer to skin, and wear performance of the adhesive are governed by the molecular weight, glass transition temperature, and the viscoelastic behavior of the adhesive. Viscoelastic properties of the adhesive as measured by the Williams plasticity number (WPN), dynamic storage modulus ( G ′), dynamic loss modulus ( G ″), and tan δ are important polymer properties for good wear performance. Sweating skin, a moist environment, and physical activity are the most important factors influencing the failure of an adhesive tape during wear. A medicalgrade adhesive for application to human skin should be hypoallergenic. Medical‐grade adhesives are utilized in making surgical tapes for holding dressings in place, adhesive bandages, adhesive dressings to cover wounds, and surgical operating drapes.
Cross-reacting material in Gaucher disease fibroblasts. (1984)

Glucocerebrosidase is the enzyme that is deficient in Gaucher diseases. Four monoclonal antibodies reacting with at least two different epitopes of this enzyme have been produced. The amounts of glucocerebrosidase in fibroblasts of patients with all three types of Gaucher disease were investigated by radioiodinating two of the antibodies and measuring their binding to fibroblast extracts immobilized on nitrocellulose filters. The amount of glucocerebrosidase antigen was decreased in all cases of Gaucher disease, particularly in the fibroblasts of patients with the more severe neuronopathic forms of the disorder, types II and III. The catalytic activity was reduced to a greater extent than the amount of antigen in all cases, so that the specific activity of the residual enzyme was found to be diminished. Although measurements in individual cases were quite reproducible and the amount of antigen detected by monoclonal antibodies reacting with different epitopes was quite similar, there was considerable variation between patients. This finding is consistent with the apparent within-type genetic heterogeneity of Gaucher disease, even within the Ashkenazi Jewish population in which it is most prevalent.
Functionalization of high-moment magnetic nanodisks for cell manipulation and separation (2013)

Synthetic antiferromagnetic (SAF) nanoparticles are layer-structured particles with high single-particle magnetic moments. In order to covalently bind these nanoparticles to cells, they were coated with a silica shell followed by conjugation with streptavidin. The silica coating generates both SAF@SiO2 core-shell nanoparticles and silica core-free nanoparticles. Using a simple magnetic separation, silica nanoparticles were removed and SAF@SiO2 nanoparticles were purified. After streptavidin conjugation, these particles were used to stain lung cancer cells, making them highly magnetically responsive. The stained cells can rotate in response to an external magnetic field and can be captured when a blood sample containing these cells flows through the sifter.
Memristor Adder Design (2018)

In this paper, the design of adders implemented with memristors is discussed. Memristor based designs for standard adder architectures (ripple carry adder, carry lookahead adder and parallel prefix adders) are explained. The area and latency are compared. Surprisingly, the Radix-2 CLA has a complexity very similar to the parallel prefix adders. It is shown that the Kogge-Stone design has the best metric in terms of delay and area among the parallel prefix adders.
Development of a robust reverse tone pattern transfer process (2017)

Pattern transfer is critical to any lithographic technology, and plays a significant role in defining the critical features in a device layer. As both the memory and logic roadmaps continue to advance, greater importance is placed on the scheme used to do the etching. For many critical layers, a need has developed which requires a multilayer stack to be defined in order to perform the pattern transfer. There are many cases however, where this standard approach does not provide the best results in terms of critical dimension (CD) fidelity and CD uniformity. As an example, when defining a contact pattern, it may be advantageous to apply a bright field mask (in order to maximize the normalized inverse log slope (NILS)) over the more conventional dark field mask. The result of applying the bright field mask in combination with positive imaging resist is to define an array of pillar patterns, which then must be converted back to holes before etching the underlying dielectric material. There have been several publications on tone reversal that is introduced in the resist process itself, but often an etch transfer process is applied to reverse the pattern tone. The purpose of this paper is to describe the use of a three layer reverse tone process (RTP) that is capable of reversing the tone of every printed feature type. The process utilizes a resist pattern, a hardmask layer and an additional protection layer. The three layer approach overcomes issues encountered when using a single masking layer. Successful tone reversal was demonstrated both on 300mm wafers and imprint masks, including the largest features in the pattern, with dimensions as great as 60 microns. Initial in-field CD uniformity is promising. CDs shifted by about 2.6nm and no change was observed in either LER or LWR. Follow-up work is required to statistically qualify in-field CDU and also understand both across wafer uniformity and feature linearity.
Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium (2002)

Vascular endothelial cells (EC) play a key role in a variety of pathophysiologic processes, such as angiogenesis, inflammation, cancer metastasis, and vascular diseases. As part of a strategy to identify all genes expressed in human EC, a full-length cDNA encoding a potential secreted protein harboring 10 epidermal growth factor (EGF)-like domains and one CUB domain at the carboxyl terminus (termed, SCUBE1 for Signal peptide-CUB-EGF-like domain containing protein 1) was identified. SCUBE1 shares homology with several protein families, including members of the fibrillin and Notch families, and the anticoagulant proteins, thrombomodulin and protein C. SCUBE1 mRNA is found in several highly vascularized tissues such as liver, kidney, lung, spleen, and brain and is selectively expressed in EC by in situ hybridization. SCUBE1 is a secreted glycoprotein that can form oligomers and manifests a stable association with the cell surface. A second gene encoding a homologue (designated SCUBE2) was also identified and is expressed in EC as well as other cell types. SCUBE2 is also a cell-surface protein and can form a heteromeric complex with SCUBE1. Both SCUBE1 and SCUBE2 are rapidly down-regulated in EC after interleukin-1beta and tumor necrosis factor-alpha treatment in vitro and after lipopolysaccharide injection in vivo. Thus, SCUBE1 and SCUBE2 define an emerging family of human secreted proteins that are expressed in vascular endothelium and may play important roles in development, inflammation, and thrombosis.
Electroacoustic pulse source for high-resolution seismic explorations (1987)

We suggest an electroacoustic pulse source with frequency characteristics, directivity pattern, and energy suitable for high-resolution prospecting on land and underwater. The seismic wave is produced by a high-energy discharge, set in the focus of a parabolic aluminum reflector filled with insulating liquids. The acoustic pulse is transmitted to the soil via a neoprene diaphragm that couples the transducer to the earth. The discharge is primed by a low-energy preliminary spark, via a third electrode between the principal electrodes, which produces the liquid ionization. An important feature of the electroacoustic source is the variation of frequency spectrum of the impulse, by changing electrical parameters such as capacitance and inductance. The directivity pattern can be changed by inching the electrodes up or down with reference to the focus. First field measurements showed better penetration capacity of the seismic wave of the paraboloid in comparison with a traditional mechanical source. This electroacoustic source can be utilized on land, and even more successfully in underwater acoustic prospecting, by providing suitable electric insulation. In this latter application the frequency range is higher than that used for land prospecting.
Broadband Electromechanical Spectroscopy: A Method for Measuring the Dynamic Electromechanical Response of Ferroelectrics (2016)

To gain a better understanding of the dynamic response of thermo-electro-mechanically coupled materials, in particular stiffness and mechanical damping, an experimental apparatus and method called Broadband Electromechanical Spectroscopy (BES) has been developed. The motivation for creating BES was to study the behavior of ferroelectric materials (and other electro-active materials) over wide ranges of frequencies of simultaneously-applied electric fields and mechanical stresses under accurate temperature control. By precisely controlling electric fields and mechanical loading, the effect of microstructural changes, in particular domain switching in ferroelectrics, on the material’s dynamic mechanical response is measured. Experiments show large increases in mechanical damping during domain switching that can be tuned by appropriate electrical loading. Results obtained using the new capabilities brought by BES can be used to better understand the damping associated with domain wall motion to be able to create ceramic materials with both high stiffness and high damping—an elusive combination of properties in typical engineering materials. The design and use of the apparatus along with results obtained from tests on a particular ferroelectric, viz. lead zirconate titanate, are presented.
Enhanced obfuscation for multi-part biometric templates (2016)

Biometrie authentication is being exceedingly utilized into mobile devices as an alternative to passwords. However, for security and privacy reasons, it is important to protect the biometric template. In this paper, we introduce a method to obfuscate and match certain biometric templates comprised of multiple local descriptors derived around spatial interest points. Obfuscation starts by insertion of chaff (fake) interest points along with their respective synthesized descriptors that are statistically similar to original descriptors. Fusion of local matches along with global outlier rejection is used to mitigate the impact of the resulting obfuscation on biometric matching accuracy. The efficacy of the proposed method is demonstrated through ocular and face recognition experiments.
Megapixel multi-band QWIP focal plane arrays (2004)

A mid-wavelength 1024x1024 pixel quantum well infrared photodetector (QW) focal plane array has been demonstrated with excellent imagery. Noise equivalent differential temperature (NETD) of 19 mK was achieved at 95K operating temperature with f/2.5 optics at 300K background. This focal plane array has shown background limited performance (BLIP) at 90K operating temperature with the same optics and background conditions. In this paper, we will discuss its performance in quantum efficiency, NETD, uniformity, and operability.
Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity (2017)

The p38 MAPK family is composed of four kinases of which p38α/MAPK14 is the major proinflammatory member. These kinases contribute to many inflammatory diseases, but the currently available p38 catalytic inhibitors (e.g., SB203580) are poorly effective and cause toxicity. We reasoned that the failure of catalytic p38 inhibitors may derive from their activity against noninflammatory p38 isoforms (e.g., p38β/MAPK11) and loss of all p38α-dependent responses, including anti-inflammatory, counterregulatory responses via mitogen- and stress-activated kinase (MSK) 1/2 and Smad3. We used computer-aided drug design to target small molecules to a pocket near the p38α glutamate-aspartate (ED) substrate-docking site rather than the catalytic site, the sequence of which had only modest homology among p38 isoforms. We identified a lead compound, UM101, that was at least as effective as SB203580 in stabilizing endothelial barrier function, reducing inflammation, and mitigating LPS-induced mouse lung injury. Differential scanning fluorimetry and saturation transfer difference-nuclear magnetic resonance demonstrated specific binding of UM101 to the computer-aided drug design-targeted pockets in p38α but not p38β. RNA sequencing analysis of TNF-α-stimulated gene expression revealed that UM101 inhibited only 28 of 61 SB203580-inhibited genes and 7 of 15 SB203580-inhibited transcription factors, but spared the anti-inflammatory MSK1/2 pathway. We provide proof of principle that small molecules that target the ED substrate-docking site may exert anti-inflammatory effects similar to the catalytic p38 inhibitors, but their isoform specificity and substrate selectivity may confer inherent advantages over catalytic inhibitors for treating inflammatory diseases.
Low-Loss Narrowband Filtering Switch Based on Coaxial Resonators (2018)

In this paper, a narrowband filtering switch with low loss and high selectivity is presented based on coaxial resonators for the first time. PIN diodes mounted on the printed circuit boards are embedded into a coaxial filter to enable ON and OFF states. In the ON-state, the PIN diodes are turned OFF, which do not introduce the loss and affect the linearity. Two transmission zeros are generated by a novel feeding structure, which improves the skirt selectivity. In the OFF-state, the PIN diodes are turned on. Then, lumped capacitors are loaded to the coaxial resonators so that the resonant frequencies of the resonators are changed. The passband at the operating frequency cannot be formed, resulting in high isolation. For demonstration, the coaxial-resonator-based filtering switch is designed and fabricated. Good agreement between simulated and measured results verifies the proposed ideas. Comparison with other reported filtering switches is given. The proposed filtering switch shows the advantages of high Q-factor, relatively compact size, and wide stopband responses, which is attractive in wireless systems.
Hardware and software integrated toolkit for low cost analog fuzzy controllers (2002)

In applications where low cost is the primary concern, analog VLSI controllers are an option. In this paper a hardware and software integrated toolkit for development of analog controllers based on fuzzy logic is presented. The system is composed of a CMOS analog circuit whose input/output relationship can be programmed to synthesize various control functions. The value of the programmable parameters is automatically computed by the software tool, assuming that the user specifies the controller expected behavior by means of linguistic and/or numeric information. A typical application featuring nine rules with two input and one output variables can be implemented in a standard CMOS 1.5 /spl mu/m technology using approximately 1.25 mm/spl times/0.3 mm of silicon area with a power consumption of 3.5 mW.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Amyotrophic lateral sclerosis immunoglobulins increase Ca<sup>2+</sup> currents in a motoneuron cell line (1995)

The sporadic form of amyotrophic lateral sclerosis (ALS) is an idiopathic and eventually lethal disorder causing progressive degeneration of cortical and spinal motoneurons. Recent studies have shown that the majority of patients with sporadic ALS have serum antibodies that bind to purified L-type voltage-gated calcium channels and that antibody titer correlates with the rate of disease progression. Furthermore, antibodies purified from ALS patient sera have been found to alter the physiologic function of voltage-gated calcium channels in nonmotoneuron cell types. Using whole-cell patch-clamp techniques, immunoglobulins purified from sera of 5 of 6 patients with sporadic ALS are now shown to increase calcium currents in a hybrid motoneuron cell line, VSC4.1. These calcium currents are blocked by the polyamine funnel-web spider toxin FTX, which has previously been shown to block Ca2+ currents and evoked transmitter release at mammalian motoneuron terminals. These data provide additional evidence linking ALS to an autoimmune process and suggest that antibody-induced increases in calcium entry through voltage-gated calcium channels may occur in motoneurons in this disease, with possible deleterious effects in susceptible neurons.
Inhibition of Spontaneous Breast Cancer Metastasis by Anti—Thomsen-Friedenreich Antigen Monoclonal Antibody JAA-F11 (2006)

Thomsen-Friedenreich antigen (TF-Ag) is expressed in many carcinomas, including those of the breast, colon, bladder, and prostate. TF-Ag is important in adhesion and metastasis and as a potential immunotherapy target. We hypothesized that passive transfer of JAA-F11, an anti-TF-Ag monoclonal antibody, may create a survival advantage for patients with TF-Ag-expressing tumors by cytotoxicity, blocking of tumor cell adhesion, and inhibition of metastasis. This was tested using in vitro models of tumor cell growth; cytotoxicity assays; in vitro, ex vivo, and in vivo models of cancer metastasis; and, finally, in vivo effects in mice with metastatic breast cancer. Unlike some anti-TF-Ag antibodies, JAA-F11 did not enhance breast carcinoma cell growth. JAA-F11 did not induce the killing of 4T1 tumor cells through complement-dependent cytotoxicity or apoptotic mechanisms. However, JAA-F11 blocked the stages of metastasis that involve the adhesion of human breast carcinoma cells to human endothelial cells (human umbilical vein endothelial cells and human bone marrow endothelial cells 60) in in vitro static adhesion models, in a perfused ex vivo model, and in murine lung vasculature in an in vivo metastatic deposit formation assay. JAA-F11 significantly extended the median survival time of animals bearing metastatic 4T1 breast tumors and caused a > 50% inhibition of lung metastasis.
High-Temperature Ethanol Fermentation and Transformation with Linear DNA in the Thermotolerant Yeast <i>Kluyveromyces marxianus</i> DMKU3-1042 (2008)

We demonstrate herein the ability of Kluyveromyces marxianus to be an efficient ethanol producer and host for expressing heterologous proteins as an alternative to Saccharomyces cerevisiae. Growth and ethanol production by strains of K. marxianus and S. cerevisiae were compared under the same conditions. K. marxianus DMKU3-1042 was found to be the most suitable strain for high-temperature growth and ethanol production at 45 degrees C. This strain, but not S. cerevisiae, utilized cellobiose, xylose, xylitol, arabinose, glycerol, and lactose. To develop a K. marxianus DMKU3-1042 derivative strain suitable for genetic engineering, a uracil auxotroph was isolated and transformed with a linear DNA of the S. cerevisiae ScURA3 gene. Surprisingly, Ura(+) transformants were easily obtained. By Southern blot hybridization, the linear ScURA3 DNA was found to have inserted randomly into the K. marxianus genome. Sequencing of one Lys(-) transformant confirmed the disruption of the KmLYS1 gene by the ScURA3 insertion. A PCR-amplified linear DNA lacking K. marxianus sequences but containing an Aspergillus alpha-amylase gene under the control of the ScTDH3 promoter together with an ScURA3 marker was subsequently used to transform K. marxianus DMKU3-1042 in order to obtain transformants expressing Aspergillus alpha-amylase. Our results demonstrate that K. marxianus DMKU3-1042 can be an alternative cost-effective bioethanol producer and a host for transformation with linear DNA by use of S. cerevisiae-based molecular genetic tools.
Data-driven Prognostics with Predictive Uncertainty Estimation using Ensemble of Deep Ordinal Regression Models (2019)

Prognostics or Remaining Useful Life (RUL) Estimation from multi-sensor time series data is useful to enable condition-based maintenance and ensure high operational availability of equipment. We propose a novel deep learning based approach for Prognostics with Uncertainty Quantification that is useful in scenarios where: (i) access to labeled failure data is scarce due to rarity of failures (ii) inherent noise ispresent in the sensor readings. The two scenarios mentioned are unavoidable sources of uncertainty in the RUL estimation process, often resulting in unreliable RUL estimates. To address (i), we formulate RUL estimation as an Ordinal Regression (OR) problem and propose LSTM-OR: deep Long Short Term Memory (LSTM) network-based approach to learn the OR function. We show that LSTM-OR naturally allows for the incorporation of censored operational instances in training along with the failed instances, leading to more robust learning. To address (ii), we propose a simple yet effectiveapproach to quantify predictive uncertainty in the RUL estimation models by training an ensemble of LSTM-OR models. Through empirical evaluation on the publicly available turbofan engine benchmark datasets, we demonstrate that LSTMOR is at par with commonly used deep metric regressionbased approaches for RUL estimation when sufficient failed instances are available for training. Importantly, LSTM-OR outperforms these metric regression-based approaches in the practical scenario where failed training instances are scarce, but sufficient operational (censored) instances are additionally available. Furthermore, our uncertainty quantification approach yields high-quality predictive uncertainty estimateswhile also leading to improved RUL estimates compared to single best LSTM-OR models.
Galactosylation of Cyclodextrins and Branched Cyclodextrins by α-Galactosidases (1994)

Transgalactosylated derivatives of cyclodextrins (CDs) and glucosyl and maltosyl CDs (G1- and G2-CDs) were synthesized by alpha-galactosidases from coffee bean and Mortierella vinacea (M. vinacea). The structures of the transfer products were analyzed by FAB-mass, 13C-NMR and methylation. Coffee bean alpha-galactosidase transferred a galactosyl residue not only to side chains of G1-CDs and G2-CDs, but also directly to CD rings. M. vinacea alpha-galactosidase transferred a galactosyl residue only to side chains of G2-CDs.
Enhancing image watermarking methods with/without reference images by optimization on second-order statistics (2002)

The watermarking method has emerged as an important tool for content tracing, authentication, and data hiding in multimedia applications. We propose a watermarking strategy in which the watermark of a host is selected from the robust features of the estimated forged images of the host. The forged images are obtained from Monte Carlo simulations of potential pirate attacks on the host image. The solution of applying an optimization technique to the second-order statistics of the features of the forged images gives two orthogonal spaces. One of them characterizes most of the variations in the modifications of the host. Our watermark is embedded in the other space that most potential pirate attacks do not touch. Thus, the embedded watermark is robust. Our watermarking method uses the same framework for watermark detection with a reference and blind detection. We demonstrate the performance of our method under various levels of attacks.