gebhart/patrepeval huggingface dataset:
Large Scale Pattern Graphene Electrode for High Performance in Transparent Organic Single Crystal Field-Effect Transistors (2010)

High quality, large grain size graphene on polycrystalline nickel film on two inch silicon wafers was successfully synthesized by the chemical vapor deposition (CVD) method. The polydimethylsiloxane (PDMS) stamping method was used for graphene transferring in this experiment. The graphene transferred onto Al2O3/ITO substrates was patterned into macroscopic dimension electrodes using conventional lithography followed by oxygen plasma etching. Experimental results show that this graphene can serve as transparent source and drain electrodes in high performance organic semiconductor nanoribbon organic field-effect transistors (OFETs), facilitating high hole injection efficiency due to the preferred work function match with the channel material: single crystalline copper phthalocyanine (CuPc) nanoribbons. The nanoribbons were grown on top of the patterned graphene via evaporate-deposition to form the FET device. The carrier mobility and on/off current ratio of such devices were measured to be as high as 0.36 cm2/(V s) and 10(4).
Chemogenetic profiling identifies<i>RAD17</i>as synthetically lethal with checkpoint kinase inhibition (2015)

Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we screened 112 known tumor suppressor genes for synthetic lethal interactions with inhibitors of the CHEK1 and CHEK2 checkpoint kinases. We identified eight interactions, including the Replication Factor C (RFC)-related protein RAD17. Clonogenic assays in RAD17 knockdown cell lines identified a substantial shift in sensitivity to checkpoint kinase inhibition (3.5-fold) as compared to RAD17 wild-type. Additional evidence for this interaction was found in a large-scale functional shRNA screen of over 100 genotyped cancer cell lines, in which CHEK1/2 mutant cell lines were unexpectedly sensitive to RAD17 knockdown. This interaction was widely conserved, as we found that RAD17 interacts strongly with checkpoint kinases in the budding yeast Saccharomyces cerevisiae. In the setting of RAD17 knockdown, CHEK1/2 inhibition was found to be synergistic with inhibition of WEE1, another pharmacologically relevant checkpoint kinase. Accumulation of the DNA damage marker γH2AX following chemical inhibition or transient knockdown of CHEK1, CHEK2 or WEE1 was magnified by knockdown of RAD17. Taken together, our data suggest that CHEK1 or WEE1 inhibitors are likely to have greater clinical efficacy in tumors with RAD17 loss-of-function.
Low field giant magnetoresistance in sputtered permalloy/Au multilayers (1996)

Polycrystalline permalloy/Au multilayers exhibit oscillatory variations in saturation magnetoresistance as a function of increasing Au layer thickness. The change in resistance is saturated in fields as low as a few Oe at room temperature leading to changes in resistance per unit field of more than 1%/Oe. These are the largest room temperature magnetic field sensitivities yet reported in simple magnetic multilayers.
End-to-End Differentiable Proving (2017)

We introduce neural networks for end-to-end differentiable proving of queries to knowledge bases by operating on dense vector representations of symbols. These neural networks are constructed recursively by taking inspiration from the backward chaining algorithm as used in Prolog. Specifically, we replace symbolic unification with a differentiable computation on vector representations of symbols using a radial basis function kernel, thereby combining symbolic reasoning with learning subsymbolic vector representations. By using gradient descent, the resulting neural network can be trained to infer facts from a given incomplete knowledge base. It learns to (i) place representations of similar symbols in close proximity in a vector space, (ii) make use of such similarities to prove queries, (iii) induce logical rules, and (iv) use provided and induced logical rules for multi-hop reasoning. We demonstrate that this architecture outperforms ComplEx, a state-of-the-art neural link prediction model, on three out of four benchmark knowledge bases while at the same time inducing interpretable function-free first-order logic rules.
Orthogonal Rendezvous Routing Protocol for Wireless Mesh Networks (2006)

Routing in multi-hop wireless networks involves the indirection from a persistent name (or ID) to a locator. Concepts such as coordinate space embedding help reduce the number and dynamism complexity of bindings and state needed for this indirection. Routing protocols which do not use such concepts often tend to flood packets during route discovery or dissemination, and hence have limited scalability. In this paper, we introduce orthogonal rendezvous routing protocol (ORRP) for meshed wireless networks. ORRP is a lightweight, but scalable routing protocol utilizing directional communications (such as directional antennas or free-space-optical transceivers) to relax information requirements such as coordinate space embedding and node localization. The ORRP source and ORRP destination send route discovery and route dissemination packets respectively in locally-chosen orthogonal directions. Connectivity happens when these paths intersect (i.e. rendezvous). We show that ORRP achieves connectivity with high probability even in sparse networks with voids. ORRP scales well without imposing DHT-like graph structures (eg: trees, rings, torus etc). The total state information required is O(N3/2) for N-node networks, and the state is uniformly distributed. ORRP does not resort to flooding either in route discovery or dissemination. The price paid by ORRP is suboptimality in terms of path stretch compared to the shortest path; however we characterize the average penalty and find that it is not severe.
Certifying an Automated Code Generator Using Formal Tools: Preliminary experiments in the GeneAuto project. (2008)

International audience
Afatinib (BIBW 2992) Development in Non-Small-Cell Lung Cancer (2011)

Afatinib (BIBW 2992), a novel aniline-quinazoline derivative, irreversibly and equipotently targets the intrinsic kinase activity of all active ErbB receptor family members. Preclinical results show that afatinib is effective in lung cancer models, including those with EGF receptor (EGFR) mutations resistant to reversible first-generation EGFR inhibitors. Afatinib is being investigated in the LUX-Lung program, which will evaluate afatinib as a first-line treatment in patients with EGFR-activating mutations (LUX-Lung 2, 3 and 6) and as a second- or third-line treatment in patients that have acquired resistance to gefitinib and/or erlotinib (LUX-Lung 1, 4 and 5). LUX-Lung 1 and 2 have demonstrated, within their respective target groups, a significant increase in the disease control rate of 58 and 86%, respectively, and significant prolongation of progression-free survival. Further Phase III clinical trials are currently ongoing to assess afatinib in combination with paclitaxel (LUX-Lung 5), and compared with cisplatin/pemetrexed (LUX-Lung 3) or cisplatin/gemcitabine (LUX-Lung 6).
American Sign Language alphabet recognition using Microsoft Kinect (2015)

American Sign Language (ASL) alphabet recognition using marker-less vision sensors is a challenging task due to the complexity of ASL alphabet signs, self-occlusion of the hand, and limited resolution of the sensors. This paper describes a new method for ASL alphabet recognition using a low-cost depth camera, which is Microsoft's Kinect. A segmented hand configuration is first obtained by using a depth contrast feature based per-pixel classification algorithm. Then, a hierarchical mode-seeking method is developed and implemented to localize hand joint positions under kinematic constraints. Finally, a Random Forest (RF) classifier is built to recognize ASL signs using the joint angles. To validate the performance of this method, we used a publicly available dataset from Surrey University. The results have shown that our method can achieve above 90% accuracy in recognizing 24 static ASL alphabet signs, which is significantly higher in comparison to the previous benchmarks.
ChemInform Abstract: Synthesis and Analgesic Activity of Novel N‐Acylarylhydrazones and Isosters, Derived from Natural Safrole. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Accuracy of Continuous Noninvasive Hemoglobin Monitoring (2014)

Although the mean difference between noninvasive Hb and central laboratory measurements was small, the wide limits of agreement mean clinicians should be cautious when making clinical decisions based on these devices.
Bioconjugation protocols : strategies and methods (2011)

Contemporary approaches to the synthesis of chemically modified biomacromolecules (proteins, nucleic acids, lipids, and carbohydrates) not only require efficient means to control conjugation and the specific site of attachment of the conjugated moiety but also the effective use of recent developments in the fields of pharmaceutical chemistry, biomolecular/polymer engineering, and nanobiotechnology. In this second edition of Bioconjugation Protocols: Strategies and Methods, expert researchers update the classic methods and introduce valuable new approaches that go beyond basic conjugation techniques to include elements from advanced organic synthesis, molecular biology, surface biotechnology, materials science, and nanobioscience/engineering. These readily reproducible methods cover the preparation of biomolecular conjugates using a variety of labeling techniques and semisynthetic approaches. Additional chapters address the biofunctionalization of surface structures, including organic/inorganic thin films, as well as various types of nanostructures (magnetic nanoparticles, quantum dots, carbon nanotubes, and silicon nanowire devices). All the protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Bioconjugation Protocols: Strategies and Methods, Second Edition offers both novice and experienced researchers access to the broad array of techniques needed to carry out the semisynthesis of functional biomolecular reagents and/or the biofunctionalization of surfaces and structures of unique interest for a wide variety of applications, ranging from novel biomedical diagnostics to powerful new therapeutics to advanced biomaterials
Optimizing customer journey using process mining and sequence-aware recommendation (2019)

Customer journey analysis aims at understanding customer behavior both in the traditional offline setting and through the online website visits. Particularly for the latter, web analytics tools like Google Analytics and customer journey maps have shown their usefulness, by being widely used by web companies. Nevertheless, they provide an oversimplified version of the user behavior in addition to other limitations related to the narrow scope over the cases. This paper contributes a novel approach to overcome these limitations by applying process mining and recommender systems techniques to web log customer journey analysis. Through our novel approach we are able to (i) discover the process that better describes the user behavior, (ii) discover and compare the processes of different behavioral clusters of users, and then (iii) use this analysis to improve the journey by optimizing some KPIs (Key Performance Indicators) via personalized recommendations based on the user behavior. In particular, with process mining it is possible to identify specific customer journey paths that can be enforced to optimize some KPIs. Then, with our novel, sequence-aware recommender system, it is possible to recommend to users particular actions that will optimize the selected KPIs, using the customer journey as an implicit feedback. The proof of the correctness of the introduced concepts is demonstrated through a real-life case study of 10 million events representing the online journeys in 1 month of 2 million users. We show and evaluate the discovered process models from this real web log, then use the extracted information from the process models to select and optimize a KPI via personalized recommendations.
Aesthetic learning processes: about a project for creative work, and how one can create learning and make it visible with the help of artistic work (2006)

Aesthetic learning processes : about a project for creative work, and how one can create learning and make it visible with the help of artistic work
Characterization of Photoluminescence from a Material Made by Interaction of (3-Aminopropyl)triethoxysilane with Acetic Acid (1998)

A new photoluminescent material has been synthesized by the interaction of (3-aminopropyl)triethoxysilane with acetic acid under oxygen-free conditions. The photophysical properties of this material in bulk form, colloidal solution, and thin films have been studied by absorption, excitation, steady-state fluorescence, time-resolved fluorescence, and Fourier transform infrared spectroscopy. These studies showed the existence of two distinct luminescent species emitting bright blue or yellow photoluminescence.
Functional Proteolytic Complexes of the Human Mitochondrial ATP-dependent Protease, hClpXP (2002)

Human mitochondrial ClpP (hClpP) and ClpX (hClpX) were separately cloned, and the expressed proteins were purified. Electron microscopy confirmed that hClpP forms heptameric rings and that hClpX forms a hexameric ring. Complexes of a double heptameric ring of hClpP with hexameric hClpX rings bound on each side are stable in the presence of ATP or adenosine 5'-(3-thiotriphosphate) (ATPgammaS), indicating that a symmetry mismatch is a universal feature of Clp proteases. hClpXP displays both ATP-dependent proteolytic activity and ATP- or ATPgammaS-dependent peptidase activity. hClpXP cannot degrade lambdaO protein or GFP-SsrA, specific protein substrates recognized by Escherichia coli (e) ClpXP. However, eClpX interacts with hClpP, and, when examined by electron microscopy, the resulting heterologous complexes are indistinguishable from homologous eClpXP complexes. The hybrid eClpX-hClpP complexes degrade eClpX-specific protein substrates. In contrast, eClpA can neither associate with nor activate hClpP. hClpP has an extra C-terminal extension of 28 amino acids. A mutant lacking this C-terminal extension interacts more tightly with both hClpX and eClpX and shows enhanced enzymatic activities but still does not interact with eClpA. Our results establish that human ClpX and ClpP constitute a bone fide ATP-dependent protease and confirm that substrate selection, which differs between human and E. coli ClpX, is dependent solely on the Clp ATPase. Our data also indicate that human ClpP has conserved sites required for interaction with eClpX but not eClpA, implying that the modes of interaction with ClpP may not be identical for ClpA and ClpX.
NMDA and AMPA Receptors in Transgenic Mice Expressing Human <i>β</i>‐Amyloid Protein (1993)

The human beta-amyloid protein may play an important, possibly primary, role in the pathogenesis of Alzheimer's disease (AD), and it appears to potentiate the susceptibility of neurons to excitotoxicity. AD is associated with alterations in the N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) subtypes of glutamate receptors, and it has been suggested that excitotoxicity may play a role in neuronal damage in AD. In this study, we have used quantitative receptor autoradiography to examine NMDA and AMPA receptors in transgenic mice that contain the gene for the carboxyl-terminal 100 amino acids of the human amyloid precursor protein, beginning with the beta-amyloid region, which is under the control of the JC viral early region promoter. Reverse transcriptase-polymerase chain reaction confirmed that the brains of transgenic mice expressed beta-amyloid mRNA and that control mice did not. NMDA receptors, assessed with [3H]MK-801, were unchanged in the transgenic compared with the control mice. In the transgenic mice, there were no significant changes in [3H]AMPA receptor binding compared with controls. This study represents the first attempt to evaluate in transgenic mice the in vivo interaction between beta-amyloid expression and excitatory amino acid receptors.
Intercenter differences in diffusion tensor MRI acquisition (2010)

Significant variability of DT-MRI data can be attributed to the acquisition center, even when a standardized protocol is used. The use of appropriate segmentation methods and statistical models allows DT-derived metrics to differentiate patients from healthy controls.
Template monomer control of the chirality induction in the polymer backbone during asymmetric vinyl polymerization (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTemplate monomer control of the chirality induction in the polymer backbone during asymmetric vinyl polymerizationGuenter Wulff and Pradeep K. DhalCite this: Macromolecules 1990, 23, 21, 4525–4527Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ma00223a005https://doi.org/10.1021/ma00223a005research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultrafast thermoreflectance techniques for measuring thermal conductivity and interface thermal conductance of thin films (2010)

The thermal conductivity of thin films and interface thermal conductance of dissimilar materials play a critical role in the functionality and the reliability of micro/nanomaterials and devices. The ultrafast laser-based thermoreflectance techniques, including the time-domain thermoreflectance (TDTR) and the frequency-domain thermoreflectance (FDTR) techniques are excellent approaches for the challenging measurements of interface thermal conductance of dissimilar materials. Both TDTR and FDTR signals on a trilayer structure which consists of a thin film metal transducer, a target thin film, and a substrate are studied by a thermal conduction model. The sensitivity of TDTR signals to the thermal conductivity of thin films is analyzed to show that the modulation frequency needs to be selected carefully for a high precision TDTR measurement. However, such a frequency selection, which is closely related to the unknown thermal properties and consequently hard to make before TDTR measurement, can be avoided in FDTR measurement. We also found out that in FDTR method, the heat transport in a trilayer structure could be divided into three regimes, and the thermal conductivity of thin films and interface thermal conductance can be obtained subsequently by fitting the data in different frequency range of one FDTR measurement, based on the regime map. Both TDTR and FDTR measurements are then conducted along with the analysis to obtain the thermal conductivity of SiO2 thin films and interface thermal conductance between SiO2 and Si. FDTR measurement results agree well with the TDTR measurements, but promises to be a much easier implementation than TDTR measurements.
Chemoprevention of rat hepatocarcinogenesis with histone deacetylase inhibitors: Efficacy of tributyrin, a butyric acid prodrug (2008)

Hepatocellular carcinoma (HCC) ranks in prevalence and mortality among top 10 cancers worldwide. Butyric acid (BA), a member of histone deacetylase inhibitors (HDACi) has been proposed as an anticarcinogenic agent. However, its short half-life is a therapeutical limitation. This problem could be circumvented with tributyrin (TB), a proposed BA prodrug. To investigate TB effectiveness for chemoprevention, rats were treated with the compound during initial phases of "resistant hepatocyte" model of hepatocarcinogenesis, and cellular and molecular parameters were evaluated. TB inhibited (p < 0.05) development of hepatic preneoplastic lesions (PNL) including persistent ones considered HCC progression sites. TB increased (p < 0.05) PNL remodeling, a process whereby they tend to disappear. TB did not inhibit cell proliferation in PNL, but induced (p < 0.05) apoptosis in remodeling ones. Compared to controls, rats treated with TB presented increased (p < 0.05) hepatic levels of BA indicating its effectiveness as a prodrug. Molecular mechanisms of TB-induced hepatocarcinogenesis chemoprevention were investigated. TB increased (p < 0.05) hepatic nuclear histone H3K9 hyperacetylation specifically in PNL and p21 protein expression, which could be associated with inhibitory HDAC effects. Moreover, it reduced (p < 0.05) the frequency of persistent PNL with aberrant cytoplasmic p53 accumulation, an alteration associated with increased malignancy. Original data observed in our study support the effectiveness of TB as a prodrug of BA and as an HDACi in hepatocarcinogenesis chemoprevention. Besides histone acetylation and p21 restored expression, molecular mechanisms involved with TB anticarcinogenic actions could also be related to modulation of p53 pathways.
A OPEN-LABEL, PROSPECTIVE RANDOMIZED TRIAL TO COMPARE TOLERABILITY AND OUTCOME FOR TWO FORMULATIONS OF MYCOPHENOLATE (2008)

Qazi, Y1,2; Takemoto, S3; Mateo, R1; Alameda, J1; Romero, C1; Schroff, S1; Tsirunyan, A3; Shah, T2,3 Author Information