gebhart/patrepeval huggingface dataset:
Histone deacetylase inhibitor screening identifies HC toxin as the most effective in intrahepatic cholangiocarcinoma cells (2016)

Histone deacetylases (HDACs) are highly expressed in intrahepatic cholangiocarcinoma (ICC) and are associated with poor prognosis of these patients. The aim of the present study was to explore the inhibitory effects of HDAC inhibitors on ICC cells and identify effective and sensitive drugs for ICC. Effects of 34 HDAC inhibitors were screened through two rounds of cell viability assays, and HC toxin, a cyclic tetrapeptide first isolated from the secondary metabolite of Helminthosporium carbonum, exhibited an antitumor activity superior to that of the other HDAC inhibitors and gemcitabine. The mechanisms involved in the inhibitory effects of HC toxin on CCLP-1 cells were investigated by cell counting, colony formation assay, cell morphological observation, real-time PCR, western blotting and flow cytometry. It was demonstrated that HC toxin inhibited the cell proliferation and clone formation ability of the CCLP-1 cells. HC toxin increased the acetyl-histone H4 level and this was associated with the inhibitory effect of HC toxin on the CCLP-1 cells. We also found that HC toxin reduced the level of HDAC1 protein in a post-transcriptional manner. Morphological observation showed multiple morphological changes and indicated the possibility of cell differentiation owing to HC toxin. With increasing concentration of HC toxin, the cell cycle was gradually arrested at the G0/G1 stage and the percentage of apoptotic cells increased which was not mainly through the caspase-3-dependent ways. These results indicated that HC toxin was the most effective among the various HDAC inhibitors with multiple functions in the suppression of ICC in vitro. Thus, HC may be a potential chemotherapeutic for ICC.
From food waste to value‐added surplus products (<scp>VASP</scp>): Consumer acceptance of a novel food product category (2017)

Abstract Over one third of the food we produce is never consumed. Such a high rate of food waste is appalling. To address this, researchers have focused on creating foods from surplus ingredients or ingredients obtained during the manufacturing of other foods. We term such foods as value‐added surplus products. But will consumers accept products made from ingredients destined for the trash bin? A series of studies that test 3 different cues that consumers utilize to evaluate foods suggests strong potential for consumer acceptance, and even preference for such foods. Study 1 tested description for value‐added surplus products alongside those for conventional and organic foods to understand whether consumers discriminate between these foods. Study 2 tested consumer preference for 9 product labels for value‐added surplus products. Study 3 examined whether benefits to self or to others will differentially influence consumers' perceptions of such value‐added foods. Collectively, these studies suggest a strong potential for such foods to command position as a new category of foods that is distinct from both conventional as well as organic foods.
Vehicle detection and tracking with low-angle cameras (2010)

Vision-based vehicle detection is a critical task for traffic monitoring in modern Intelligent Traffic Systems (ITS). Due to the low-angle nature of most traffic surveillance cameras installed in the real world, vehicle detection in such case has to deal with one fundamental challenge — occlusion, which renders most traditional vehicle detection methods ineffective. In this paper, instead of detecting the vehicle as a whole, we propose a vehicle detection algorithm based on windshield model matching. By detecting windshield directly, the algorithm achieves robustness to occlusion. Together with camera calibration and vehicle tracking, the system is able to provide reliable traffic state estimation. Experiments on real traffic videos demonstrate the better performance of our system compared to the state-of-the-art algorithm.
Self-Assembly and Photo-Cross-Linking of Eight-Armed PEG-PTMC Star Block Copolymers (2011)

Eight-armed poly(ethylene glycol)-poly(trimethylene carbonate) star block copolymers (PEG-(PTMC)(8)) linked by a carbamate group between the PEG core and the PTMC blocks were synthesized by the metal-free, HCl-catalyzed ring-opening polymerization of trimethylene carbonate using an amine-terminated eight-armed star PEG in dichloromethane. Although dye solubilization experiments, nuclear magnetic resonance spectroscopy, and dynamic light scattering clearly indicated the presence of aggregates in aqueous dispersions of the copolymers, no physical gelation was observed up to high concentrations. PEG-(PTMC(9))(8) was end-group-functionalized using acryloyl chloride and photopolymerized in the presence of Irgacure 2959. When dilute aqueous dispersions of PEG-(PTMC(9))(8)-Acr were UV irradiated, chemically cross-linked PEG-PTMC nanoparticles were obtained, whereas irradiation of more concentrated PEG-(PTMC(9))(8)-Acr dispersions resulted in the formation of photo-cross-linked hydrogels. Their good mechanical properties and high stability against hydrolytic degradation make photo-cross-linked PEG-PTMC hydrogels interesting for biomedical applications such as matrices for tissue engineering and controlled drug delivery systems.
Influence of particle size and type of formulation on phytotoxicity and persistence of atrazine (1984)

Summary: The initial and residual activities of wettable powder formulations of atrazine comprising different particle sizes were investigated in field and glasshouse experiments. A flowable formulation was also compared with these. Oats were used as the test species for the glasshouse studies while in field trials effects on control of broadleaf weeds in maize were studied. No marked differences were noted in the activity of wettable powders of different particle sizes in the glasshouse as pre‐emergence applications. As a post‐emergence treatment the fine particle size was more phytotoxic than the coarse material, especially when a wetting agent was added to the spray solution. In the field trials, no appreciable differences in weed control or crop tolerance could be established regardless of the time or rate of application. The flowable formulation was less active than the wettable powders in some glasshouse experiments but no such trend was apparent in field trials. Bioassays showed that the residual activity of the flowable formulation was lower than wettable powder formulations in both glasshouse and field studies but no consistent differences were noted in the persistence of the three forms of wettable powders.
Macmillan Dictionary of Genetics and Cell Biology (1987)

Alphabetical entries - table of common abbreviations and of species commonly used in research - bibliography of recommended texts - 75 diagrams and tables
Symbolic analysis for improving simulation coverage of Simulink/Stateflow models (2008)

Aimed at verifying safety properties and improving simulation coverage for hybrid systems models of embedded control software, we propose a technique that combines numerical simulation and symbolic methods for computing state-sets. We consider systems with linear dynamics described in the commercial modeling tool Simulink/Stateflow. Given an initial state x, and a discrete-time simulation trajectory, our method computes a set of initial states that are guaranteed to be equivalent to x, where two initial states are considered to be equivalent if the resulting simulation trajectories contain the same discrete components at each step of the simulation. We illustrate the benefits of our method on two case studies. One case study is a benchmark proposed in the literature for hybrid systems verification and another is a Simulink demo model from Mathworks.
Structures and Antitumor Activities of the Polysaccharides Isolated from Fruiting Body and the Growing Culture of Mycelium of Ganoderma lucidum (1985)

Several β-D-glucans, appertaining to the same molecular species but having different degrees of branching, were isolated from water and alkali extracts of the fruiting body of Ganoderma lucidum (Reishi). The purified glucans that were mostly water-insoluble had a backbone of (1 →3)-linked D-glucose residues, attached mainly with single D-glucosyl units at 0-6 and also with a few short (l→4)-linked glucosyl units at 0-2 positions. However, their degrees of branching appeared to differ in the range of d.b. 1/3 ~ 1/23, depending on the extracted glucan fractions. In addition to the ^-glucans, the fruiting body contained water-soluble heteropolysaccharides, comprising D-glucose, D-galactose, D-mannose, L-(or D)-arabinose, D-xylose, and L-fucose. A branched (1 →3)-β-D-glucan was also isolated from the culture filtrate of G. lucidum grown in a glucose-yeast extract medium. The extracellular β-D-glucan was less soluble in water after purification, but soluble in dilute alkali. This glucan has essentially the same structure as that of hot-water extracted polysaccharide from the fruiting body. The repeating unit of the glucan contains a backbone chain of (1 →3)-linked D-glucose residues, five out of sixteen D-glucose residues being substituted at 0-6 positions with single D-glucosyl units and one D-glucose residue at 0-2 positions probably with a cellobiose unit. The hot-water extractable fruiting body glucan and the extracellular glucan of the culture of growing mycelium showed relatively high growth-inhibition activities against Sarcoma 180 solid tumor in mice, when administered by. successive intraperitoneal injections. When the moderately branched glucans were modified to D-glucan-polyols by periodate oxidation and borohydride reduction, they exhibited higher antitumor activities, confirming the previous conclusion that the attachment of polyol groups to the (1 →3)-lmked backbone significantly enhances its host-mediated antitumor effect.
Non-Destructive Testing: Proceedings of the 12th World Conference on Non-Destructive Testing, Amsterdam, the Netherlands, April 23-28, 1989 (1989)

Subject Indexes. Author Index. Volume 1: 1. Plenary Lectures. 2. Techniques. Radiography. Radiography and radiation techniques. Real time radiography. X-ray tomography. Radiographic techniques. Ultrasonic testing. Ultrasonic testing and automated systems. Advanced ultrasonic testing and imaging. Ultrasonic techniques. Electromagnetic testing. Electromagnetic techniques. Electromagnetic testing applications. Electromagnetic and eddy current techniques. Magnetic particle and penetrant testing. Penetrant testing techniques. Acoustic emission. Acoustic emission (steel). Acoustic emission (composites etc.). Acoustic emission (in-service inspection). Acoustic emission and miscellaneous techniques. Optical and infrared techniques. Stress and strain measurements. Condition monitoring. New techniques. 3. Sensors and Equipment. NDT equipment. Sensors. Trends in equipment. 4. NDT and Computers. Impact of computers on NDT. Imaging. Signal processing, data presentation, image analysis. Modelling. Expert systems and pattern recognition. Volume 2: 5. Applications of NDT. Applications in steel industry. Applications in chemical and petrochemical process industry. Applications in nuclear and electricity industry. Applications in off-shore. Applications in aerospace. Applications in civil works. Applications in civil engineering. NDT of civil works. NDT and manufacturing. Product quality. Instrumentation and techniques for product and quality control. Inspection in manufacturing. NDT aspects at manufacturing. Materials research. NDT and materials research. Materials research on steels (UT and AE techniques). Materials research on steels (electromagnetical techniques). Materials research on steels (various techniques). Inspection of advanced materials, composites, bonded structures. NDT of concrete. Applications of NDT on composites and advanced materials. Composites and advanced materials (NDT techniques/instrumentation). Trends in NDT. 6. Fitness for Purpose. Characterization of discontinuities. Reliability of NDT. Life-time assessment. 7. Training and Standards. Personnel education and training schemes. Education and training. Certification and qualification. NDT standards development. Equipment qualification standards. NDT in developing countries.
Human subjects exposed to a specific pulsed extremely low frequency magnetic field: Effects on standing balance (2001)

Extremely low frequency pulsed magnetic fields (±200 μT, ∼400 mT/s, 0–1 kHz) may produce electric currents similar to action potentials, which in turn would be expected to produce detectable physiological or behavioral effects in human subjects. This thesis reports on the effects of pulsed extremely low frequency magnetic fields (ELFMFs) on human standing balance by measurement of postural sway on a force platform utilizing a double blind protocol with four randomly assigned 2 min exposure conditions (eyes open/closed, sham/ELFMF) within each subject's session. Historically, and in current research by others, normal postural sway has been well characterized. Standing balance in humans is a largely automatic behavior and with “eyes open” is a robust behavior not easily disrupted by small perturbations. However, with “eyes closed” standing balance becomes very sensitive to perturbation by a wide variety of stimuli. Since we have shown that ELFMF perturbs human postural sway, measurements of standing balance may be an ideal method of investigating bioelectromagnetic coupling mechanisms in humans (i.e., peripheral versus central nervous system mechanisms). Ideal because, being under automatic control, standing balance is an objective measure not subject to placebo effects. The coupling mechanisms can be studied by examining the effects related to different anatomical location of ELFMF exposure, or studying patients with different pathology. This thesis has established that normal standing balance is perturbed by weak ELFMF for both eyes open/eyes closed conditions. Also, it has been established that this human assay may indeed be appropriate to study coupling mechanisms, since the ability of ELFMF to affect sway varies between patients with diseases affecting different anatomical and physiological centers.
Urethane dimethacrylate oligomers for dental composite matrix: Synthesis and properties (2009)

Abstract Two urethane poly(ethylene oxide) dimethacrylates based on polyether diol of variable length ( M n : 300 and 1000 g/mol), isophorone diisocyanate and 2‐hydroxyethyl methacrylate, were synthesized and characterized to be used as comonomers for dental composites. The polymerization process initiated with benzoyl peroxide/amine or camphorquinone/tertiary amine couple was followed by a combination of FTIR spectroscopy and fluorescence technique using a pyrene probe for the in situ monitoring of microscopic changes in the polymeric systems. Difference in the polymerization kinetics of the oligomers and low‐molecular‐weight monomer is presented in connection with the chemical structure of the urethane dimethacrylate, taken together with another partners (bisGMA, TEGDMA, filler) with effect on the mobility and reactivity of the formed polymeric network. The results suggest a higher reactivity of the oligomeric forms and are in agreement with the fluorescence measurements induced of the pyrene molecule, whosemonomer fluorescence emission significantly increased with irradiation time as the network formation occurred. Measurements of the contact angle showed the maintenance of the hydrophilic nature of these resins, while the values of polymerization shrinkage and diametral tensile and compressive strengths of the three specimens indicated that the incorporation of dimethacrylate urethane oligomers in the organic matrix (18 wt%) led to materials with good properties. POLYM. ENG. SCI., 2009. © 2009 Society of Plastics Engineers
Local Immune Stimulation by Intravesical Instillation of Baculovirus to Enable Bladder Cancer Therapy (2016)

Abstract Intravesical instillation of Bacillus Calmette-Guérin is currently used as adjuvant therapy for superficial, non-muscle invasive bladder cancer (NMIBC). However, nearly 40% of patients with NMIBC will fail Bacillus Calmette-Guérin therapy. In an attempt to investigate the feasibility of using insect baculovirus-based vectors for bladder cancer therapy, we observed that intravesical instillation of baculoviruses without transgene up-regulated a set of Th1-type of cytokines and increased the survival rate of mice bearing established orthotopic bladder tumors. When baculoviral vectors were used to co-deliver the mouse CD40 ligand and IL-15 genes through intravesical instillation, the immunogene therapy triggered significantly increased bladder infiltrations of inflammatory monocytes, CD4 + , CD8 + and γδ T lymphocytes. All treated animals survived beyond 12 months whereas control animals died around 2 months after tumor inoculation. We conclude that direct intravesical instillation of baculoviral gene transfer vectors holds the potential to be a novel therapeutic modality for NMIBC.
I.H.P. SAW technology and its application to micro acoustic components (2017)

I.H.P. SAW (Incredible High-Performance SAW) has a novel multi-layered structure to confine SAW energy in substrate surface area, and it shows extremely high quality (Q) factor, low temperature coefficient of frequency (TCF) and improved electromechanical coupling coefficient (K2). This paper introduces its mechanism of the high acoustic Q factor, both theoretically and experimentally, and its applications to new LTE band filters and multiplexers for Carrier Aggregation service.
The Power of Market Creation (2015)

To create broad-based and sustainable economic growth, governments in the developing world should foster market-creating innovation�that is, the generation of new products and services that reach an entirely new population of customers.
Local ensemble Kalman filtering in the presence of model bias (2006)

We modify the local ensemble Kalman filter (LEKF) to incorporate the effect of forecast model bias. The method is based on augmentation of the atmospheric state by estimates of the model bias, and we consider different ways of modeling (i.e. parameterizing) the model bias.We evaluate the effectiveness of the proposed augmented state ensemble Kalman filter through numerical experiments incorporating various model biases into the model of Lorenz and Emanuel. Our results highlight the critical role played by the selection of a good parameterization model for representing the form of the possible bias in the forecast model. In particular, we find that forecasts can be greatly improved provided that a good model parameterizing the model bias is used to augment the state in the Kalman filter.
The <i>Pseudomonas aeruginosa</i> Proteome during Anaerobic Growth (2005)

Isotope-coded affinity tag analysis and two-dimensional gel electrophoresis followed by tandem mass spectrometry were used to identify Pseudomonas aeruginosa proteins expressed during anaerobic growth. Out of the 617 proteins identified, 158 were changed in abundance during anaerobic growth compared to during aerobic growth, including proteins whose increased expression was expected based on their role in anaerobic metabolism. These results form the basis for future analyses of alterations in bacterial protein content during growth in various environments, including the cystic fibrosis airway.
Non-Lethal Weapons: A Fatal Attraction?: Military Strategies and Technologies for 21st Century Conflict (1997)

Non-lethal weapons and the post-cold war environment technology and the intervention of non-lethal weapons policy, doctrine, strategy, operations controls and constraints - legal and ethical dilemmas strategic implications into the 21st century - the concept of benign intervention the future role of non-lethal weapons.
Protein<i>N</i>-Glycosylation along the Secretory Pathway:  Relationship to Organelle Topography and Function, Protein Quality Control, and Cell Interactions (2002)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProtein N-Glycosylation along the Secretory Pathway: Relationship to Organelle Topography and Function, Protein Quality Control, and Cell InteractionsJürgen RothView Author Information Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH-8091 Zurich, Switzerland Cite this: Chem. Rev. 2002, 102, 2, 285–304Publication Date (Web):January 22, 2002Publication History Received16 July 2001Published online22 January 2002Published inissue 1 February 2002https://pubs.acs.org/doi/10.1021/cr000423jhttps://doi.org/10.1021/cr000423jresearch-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views3741Altmetric-Citations328LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cancer,Cells,Oligosaccharides,Peptides and proteins,Quality control Get e-Alerts
Dairy cattle breeding programme in Brazil development of the Brazilian milking hybrid (MLB) (2000)

combining dairy, reproduction, growth and adaptation traits, while developing cattle suitable
Organic reactions at alumina surfaces. A mechanistic and synthetic study of sulfonate ester elimination reactions effected by chromatographic alumina (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic reactions at alumina surfaces. A mechanistic and synthetic study of sulfonate ester elimination reactions effected by chromatographic aluminaGary H. Posner, George M. Gurria, and Kevin A. BabiakCite this: J. Org. Chem. 1977, 42, 19, 3173–3180Publication Date (Print):September 1, 1977Publication History Published online1 May 2002Published inissue 1 September 1977https://pubs.acs.org/doi/10.1021/jo00439a014https://doi.org/10.1021/jo00439a014research-articleACS PublicationsRequest reuse permissionsArticle Views384Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts