gebhart/patrepeval huggingface dataset:
Viscoelastic characterization of dispersive media by inversion of a general wave propagation model in optical coherence elastography (2018)

Determining the mechanical properties of tissue such as elasticity and viscosity is fundamental for better understanding and assessment of pathological and physiological processes. Dynamic optical coherence elastography uses shear/surface wave propagation to estimate frequency-dependent wave speed and Young’s modulus. However, for dispersive tissues, the displacement pulse is highly damped and distorted during propagation, diminishing the effectiveness of peak tracking approaches. The majority of methods used to determine mechanical properties assume a rheological model of tissue for the calculation of viscoelastic parameters. Further, plane wave propagation is sometimes assumed which contributes to estimation errors. To overcome these limitations, we invert a general wave propagation model which incorporates (1) the initial force shape of the excitation pulse in the space-time field, (2) wave speed dispersion, (3) wave attenuation caused by the material properties of the sample, (4) wave spreading caused by the outward cylindrical propagation of the wavefronts, and (5) the rheological-independent estimation of the dispersive medium. Experiments were conducted in elastic and viscous tissue-mimicking phantoms by producing a Gaussian push using acoustic radiation force excitation, and measuring the wave propagation using a swept-source frequency domain optical coherence tomography system. Results confirm the effectiveness of the inversion method in estimating viscoelasticity in both the viscous and elastic phantoms when compared to mechanical measurements. Finally, the viscoelastic characterization of collagen hydrogels was conducted. Preliminary results indicate a relationship between collagen concentration and viscoelastic parameters which is important for tissue engineering applications.
Ambipolar Gate Modulation Technique for the Reduction of Offset and Flicker Noise in Graphene Hall-Effect Sensors (2021)

There is a constant need for Hall-effect magnetic sensors with lower noise and lower offset for the high accuracy analog applications driven primarily by industrial and automotive markets, for example, high dynamic range current sensing for battery management in electric vehicles. Graphene-based Hall sensors (GHSs) demonstrate low thermal noise due to their high carrier mobility but suffer from large low-frequency flicker noise and offset limiting the prevalent low-frequency applications. In this paper, we present the results of a recently proposed gate modulation scheme for GHSs that uses dynamic ambipolar operation to up-convert the input magnetic signal to higher modulating frequencies while the offset and flicker noise remain spectrally unchanged and thus enabling thermal noise limited performance. We implement a prototype GHS using a scalable fabrication process with CVD graphene transferred on to silicon-oxide and followed by standard thin film and subsequent photolithographic processes. The measurement results confirm the effectiveness of dynamic ambipolar gate modulation technique in producing low offset of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$- 524\,\,\mu \mathrm{T}$ </tex-math></inline-formula> in conjunction with three orders of magnitude estimated improvement in the low frequency noise performance.
Strategy to improve the female fertility in the general gynecologist's office: use of a nutritional supplement based on myo-inositol/D-chiro-inositol and antioxidants (2021)

Subfertility is more than a quality-of-life problem as it has a substantial negative public health impact. Polycystic ovary syndrome (PCOS) is one of the most common causes of subfertility, affecting one out of 10 women in reproductive age. Among PCOS women undergoing assisted reproductive technology, treatment based on myo-inositol and high doses of D-chiro-inositol has been shown to increase pregnancy rate and number of live births, reduce ovarian hyperstimulation syndrome and improve oocyte quality. A preparation based on myo-inositol and high doses of D-chiro-inositol, together with antioxidants, vitamins, and minerals, could have beneficial effects and be an optimal strategy to improve female fertility in the general gynecologist's office. The aim of this review is to highlight the role of inositol and its isomers in improving fertility of women with PCOS.
Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice (2016)

Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mast cells in the bone marrow and other organ organs/tissues. Mutations in KIT, most frequently KIT D816V, are detected in over 80% of all systemic mastocytosis patients. While most systemic mastocytosis patients suffer from an indolent disease variant, some present with more aggressive variants, collectively called "advanced systemic mastocytosis", which include aggressive systemic mastocytosis, systemic mastocytosis with an associated hematologic, clonal non mast cell-lineage disease, and mast cell leukemia. Whereas patients with indolent systemic mastocytosis have a near normal life expectancy, patients with advanced systemic mastocytosis have a reduced life expectancy. Although cladribine and interferon-alpha are of benefit in a group of patients with advanced systemic mastocytosis, no curative therapy is available for these patients except possible allogeneic hematopoietic stem cell transplantation. Recent studies have also revealed additional somatic defects (apart from mutations in KIT) in a majority of patients with advanced systemic mastocytosis. These include TET2, SRSF2, ASXL1, RUNX1, JAK2, and/or RAS mutations, which may adversely impact prognosis and survival in particular systemic mastocytosis with an associated hematological neoplasm. In addition, several additional signaling molecules involved in the abnormal proliferation of mast cells in systemic mastocytosis have been identified. These advances have led to a better understanding of the biology of advanced systemic mastocytosis and to the development of new targeted treatment concepts. Herein, we review the biology and pathogenesis of advanced systemic mastocytosis, with a special focus on novel molecular findings as well as current and evolving therapeutic options.
In Vivo Model to Study the Biocompatibility of Peritoneal Dialysis Solutions (1997)

This study was designed to analyze the complex morphologic and functional effects of dialysis solutions on peritoneum in a rat model on chronic peritoneal dialysis. Peritoneal catheters were inserted into 10 male, Wistar rats and the animals were dialyzed twice daily for 4 weeks with 4.25% Dianeal. During the study we observed two opposite effects: healing of the peritoneum after catheter implantation--decreased cell count in dialysate, decreased permeability of the peritoneum to glucose and total protein, increased volume of drained dialysate; and damage to the membrane due to its exposure to peritoneal dialysis solution--increased hyaluronic acid levels in dialysate, a tendency of the peritoneum to thicken when compared to non-dialyzed animals. Our rat model of CAPD may be used for quantitative and qualitative assessment of the effects of peritoneal dialysis solution on the peritoneum during chronic dialysis.
Word-lattice based spoken-document indexing with standard text indexers (2008)

Indexing the spoken content of audio recordings requires automatic speech recognition, which is as of today not reliable. Unlike indexing text, we cannot reliably know from a speech recognizer whether a word is present at a given point in the audio; we can only obtain a probability for it. Correct use of these probabilities significantly improves spoken-document search accuracy.
Automatically and accurately conflating orthoimagery and street maps (2004)

Recent growth of the geospatial information on the web has made it possible to easily access various maps and orthoimagery. By integrating these maps and imagery, we can create intelligent images that combine the visual appeal and accuracy of imagery with the detailed attribution information often contained in diverse maps. However, accurately integrating maps and imagery from different data sources remains a challenging task. This is because spatial data obtained from various data sources may have different projections and different accuracy levels. Most of the existing algorithms only deal with vector to vector spatial data integration or require human intervention to accomplish imagery to map conflation. In this paper, we describe an information integration approach that utilizes common vector datasets as "glue" to automatically conflate imagery with street maps. We present efficient techniques to automatically extract road intersections from imagery and maps as control points. We also describe a specialized point pattern matching algorithm to align the two point sets and conflation techniques to align the imagery with maps. We show that these automatic conflation techniques can automatically and accurately align maps with images of the same area. In particular, using the approach described in this paper, our system automatically aligns a set of TIGER maps for an area in El Segundo, CA to the corresponding orthoimagery with an average error of 8.35 meters per pixel. This is a significant improvement considering that simply combining the TIGER maps with the corresponding imagery based on geographic coordinates provided by the sources results in error of 27 meters per pixel.
Reflection based fiber-optic displacement sensor (1986)

We present a simple and inexpensive fiberoptic displacement sensor based on the inverse-square attenuation of light reflected from a diffuse surface. A ratio scheme provides immunity from variations in surface color and finish. A design method for determining sensor parameters is provided, and experimental results for a prototype sensor are discussed.
A Graphene-Based Microfluidic Platform for Electrocrystallization and In Situ X-ray Diffraction (2018)

Here, we describe a novel microfluidic platform for use in electrocrystallization experiments. The device incorporates ultra-thin graphene-based films as electrodes and as X-ray transparent windows to enable in situ X-ray diffraction analysis. Furthermore, large-area graphene films serve as a gas barrier, creating a stable sample environment over time. We characterize different methods for fabricating graphene electrodes, and validate the electrical capabilities of our device through the use of methyl viologen, a redox-sensitive dye. Proof-of-concept electrocrystallization experiments using an internal electric field at constant potential were performed using hen egg-white lysozyme (HEWL) as a model system. We observed faster nucleation and crystal growth, as well as a higher signal-to-noise for diffraction data obtained from crystals prepared in the presence of an applied electric field. Although this work is focused on the electrocrystallization of proteins for structural biology, we anticipate that this technology should also find utility in a broad range of both X-ray technologies and other applications of microfluidic technology.
Comparison of retinal thickness by Fourier-domain optical coherence tomography and OCT retinal image analysis software segmentation analysis derived from Stratus optical coherence tomography images (2011)

High correspondence of RT measurements is obtained not only for RT but also for the segmentation of intraretinal layers between FD-OCT and StratusOCT-derived OCTRIMA analysis. However, a correction factor is required to compensate for OCT-specific differences to make measurements more comparable to any available OCT device.
A New Photovoltaic System Topology Through Load Management (2017)

Conventional photovoltaic (PV) systems are designed to compensate for the intermittent nature of solar energy, and therefore require multiple power-managing components like storage batteries, maximum power point trackers, and charge controllers. Each of these components adds an additional cost and has an associated power loss. In this paper, we present a new topology for PV systems. Instead of managing the power from the PV array, our system manages the loads and matches them to the instantaneous maximum power available from the PV array. This results in a far simpler system than conventional systems with a higher efficiency and lower cost for various applications.
Measurements of magnetostrictive properties of metallic glass using a fiber-optic interferometer (1984)

Optical-fiber interferometry has been studied and exploited in the area of fiber-optic sensors. The optical-fiber element has been shown to give a linear phase shift response to many physical perturbations over many orders of magnitude. Limitations of the interferometers response are usually governed by the demodulation scheme converting the optical phase shift to an electrical signal. However, dynamic ranges in excess of 107 have been demonstrated.1 The minimum detectable phase shift in the interferometer corresponds to path length changes of m. Thus the optical-fiber interferometer can serve as a highly sensitive means of measuring the magnetostrictive properties of magnetic materials. This capability has been further increased by recent advances in fiber-optic magnetic sensors,2 which extends measurements to dc.3 Thus this technique allows a unique method of determining both the ac and do response of the material. Accurate characterization of the magnetostrictive properties of materials, as well as being intrinsically significant, is specifically important to the field of magnetic sensors.
Volume-Wise Application of Principal Component Analysis on Masked Dynamic PET Data in Sinogram Domain (2006)

Most of the methods used for analyzing PET data are applied in the spatial domain (image domain), in which reconstructed images contain all different types of effects and errors caused by the reconstruction algorithm such as correlation in-between pixels, correlations in-between frames, and streak-artifacts. In this paper, we have investigated a new, pixel wise, noise prenormalization method used for transformation of input data followed by volume-wise application of principal component analysis (PCA) on masked dynamic PET data in the sinogram domain. We are aiming to improve the performance of PCA and to provide images with improved quality and signal extraction. We compare the performance of PCA and the image quality obtained with the new method with previously published approaches. The results show improvement of performance of PCA with respect to image quality, signal extraction, precision, and visualization.
A continuous affinity ultrafiltration process for trypsin purification (1988)

A continuous process has been devised and tested for purification of a crude trypsin preparation from pig pancreas. The development was based on the principles of affinity chromatography and Ultrafiltration. Trypsin was selectively attracted by a water-soluble high molecular weight (>100,000) polymer, bearing a potent and specific trypsin inhibitor, m-aminobenzamidine. The trypsin-macroligand complex was then retained by using an appropriate Ultrafiltration membrane, while impurities could pass through. The bound trypsin was eluted by either arginine or benzamidine. The process also featured provision for recirculation of the eluant as well as the macroligand. It was demonstrated that this purification process could purify trypsin from the crude preparation with a yield of 77%, contaminated with only 3% of impurities. For the first time, a serious attempt has been made toward continuous purification of enzymes by the affinity Ultrafiltration technique. Besides a substantial increase in productivity, the affinity polymer could be easily reconditioned and expected to possess a long operative life. Such characteristics undoubtedly will play an important role in reducing the cost of trypsin purification.
Intersection Decision Support Surveillance System: Design, Performance and Initial Driver Behavior Quantization (2007)

In rural Minnesota, approximately one-third of all crashes occur at intersections. Analysis of crash statistics and reports of crashes at rural expressway through-stop intersections shows that, for drivers who stop before entering the intersection, the majority of crashes involve an error in selecting a safe gap in traffic. The Intersection Decision Support system, developed at the University of Minnesota, is intended to reduce the number of driver errors by providing better information about oncoming traffic to drivers stopped at intersections. \n\nThis report deals primarily with the surveillance technology which serves as the foundation upon which the IDS system will be built. Three components of the surveillance system are described in detail in the body of the report: 1) a Mainline Sensor subsystem; 2) a Minor Road Sensor subsystem; 3) a Median Sensor subsystem. These subsystems include radar units, laser-scanning sensors, and infrared cameras, integrated with a vehicle tracking and classification unit that estimates the states of all vehicles approaching the intersection. The design, installation, performance, and reliability of each of these three subsystems are documented in the report. \n\nThe report concludes with an analysis of driver gap acceptance behavior at an instrumented intersection. Gap selection is examined as a function of time of day, traffic levels, weather conditions, maneuver, and other parameters. Log-normal distributions describe gaps acceptance behavior at rural, unsignalized expressway intersections.
Stabilization and Solidification of Elemental Mercury for Safe Disposal and/or Long-Term Storage (2011)

A simple and highly effective stabilization/solidification (S/S) technology of elemental mercury using only sulfur with paraffin is introduced. First, elemental mercury is mixed with an excess of sulfur powder and heated to 60 degrees C for 30 min until elemental mercury is converted into mercuric sulfide (HgS black, metacinnabar) (Step 1). Then, metacinnabar with additional sulfur is poured into liquid paraffin (Step 2). Finally, the mixture is melted at 140 degrees C and settles to the bottom of the vessel where it cools and solidifies under the layer of liquid paraffin (Step 3). The proposed S/S method with sodium sulfide nonahydrate (Na2S x 9H2O) as an additive is also tested for comparison. The average toxicity characteristic leaching procedure test values are 6.72 microg/L (no additive) and 3.18 microg/L (with additive). Theses concentrations are well below the Universal Treatment Standard (25 microg/L). Effective diffusion coefficient evaluated from accelerated leach test and average headspace concentration of Hg vapor after 18 hr are 3.62 x 10(-15) cm2/sec, 0.55 mg/m3 (no additive) and 5.86 x 10(-13) cm2/sec, 0.25 mg/m3 (with additive).
Assessment of Minimally Invasive Device That Provides Simultaneous Adjustable Cardiac Support and Active Synchronous Assist in an Acute Heart Failure Model (2011)

One of the major maladaptive changes after a major heart attack or cardiac event is an initial decline in pumping capacity of the heart leading to activation of a variety of compensatory mechanisms, and subsequently a phenomenon known as cardiac or left ventricular remodeling, i.e., a geometrical change in the architecture of the left ventricle. Evidence suggests that the local mechanical environment governs remodeling processes. Thus, in order to control two important mechanical parameters, cardiac size and cardiac output, we have developed a minimally invasive direct cardiac contact device capable of providing two actions simultaneously: (1) adjustable cardiac support to modulate cardiac size and (2) synchronous active assist to modulate cardiac output. As a means of enabling experiments to determine the role of these mechanical parameters in reverse remodeling or ventricular recovery, the device was further designed to (1) be deployed via minimally invasive surgical procedures, (2) allow uninhibited motion of the heart, (3) remain in place about the heart via an intrinsic pneumatic attachment, and (4) provide direct cardiac compression without aberrantly inverting the curvature of the heart. These actions and features are mapped to particular design solutions and assessed in an acute implantation in an ovine model of acute heart failure (esmolol overdose). The passive support component was used to effectively shift the EDPVR leftward, i.e., counter to the effects of disease. The active assist component was used to effectively decompress the constrained heart and restore lost cardiac output and stroke work in the esmolol failure model. It is expected that such a device will provide better control of the mechanical environment and thereby provide cardiac surgeons a broader range of therapeutic options and unique intervention possibilities.
Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes (2010)

Anionic phthalocyanines inhibited efficiently telomerase activity even in the presence of excess double-stranded DNA (dsDNA) because of their selective binding to telomere G-quadruplex, although low selectivity of a typical cationic ligand, TMPyP4, to the G-quadruplex allowed telomerase reaction under conditions with dsDNA.
Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control (2004)

The ubiquitous intracellular parasite Toxoplasma gondii (phylum Apicomplexa) differentiates into an encysted form (bradyzoite) that can repeatedly re-emerge as a life-threatening acute infection (tachyzoite) upon impairment of immunity. Since the switch from tachyzoite to bradyzoite is a stress-induced response, we sought to identify components related to the phosphorylation of the alpha subunit of eIF2 (eukaryotic initiation factor-2), a well-characterized event associated with stress remediation in other eukaryotic systems. In addition to characterizing Toxoplasma eIF2alpha (TgIF2alpha), we have discovered a novel eIF2 protein kinase, designated TgIF2K-A (Toxoplasma gondii initiation factor-2kinase). Although the catalytic domain of TgIF2K-A contains sequence and structural features that are conserved among members of the eIF2 kinase family, TgIF2K-A has an extended N-terminal region that is highly divergent from other eIF2 kinases. TgIF2K-A specifically phosphorylates the regulatory serine residue of yeast eIF2alpha in vitro and in vivo, and can modulate translation when expressed in the yeast model system. We also demonstrate that TgIF2K-A phosphorylates the analogous regulatory serine residue of recombinant TgIF2alpha in vitro. Finally, we demonstrate that TgIF2alpha phosphorylation in tachyzoites is enhanced in response to heat shock or alkaline stress, conditions known to induce parasite differentiation in vitro. Collectively, this study suggests that eIF2 kinase-mediated stress responses are conserved in Apicomplexa, and a novel family member exists that may control parasite-specific events, including the clinically relevant conversion into bradyzoite cysts.
Polyethylene Fibrids: Preparation and Properties (1978)

Abstract Polyethylene fibrids are small fibers having lengths of up to some millimeters, which are highly oriented and which have a morphology similar to that of cellulose fibers. The preparation of polyethylene fibrids is based on shear‐induced crystallization, a process in which the polyethylene crystallizes from solution under the influence of an elongated flow in the form of so‐called shish‐kebabs. Polymerization under shear conditions and the flash spinning of polyethylene solutions are the main processes for the preparation of PE fibrids. They may be hydrophilized by an additional process step.—Because of their cellulose‐like morphology, (hydrophilized) polyethylene fibrids have interesting properties, e.g. high adsorption capacity and the ability to form hydrogen bonds. In addition, the possibility of undertaking chemical reactions on the surface of the fibrids should be mentioned.