gebhart/patrepeval huggingface dataset:
A Dual-Mode Actuation and Sensing Scheme for In-Run Calibration of Bias and Scale Factor Errors in Axisymmetric Resonant Gyroscopes (2017)

This paper demonstrates a dual-mode actuation and sensing scheme for differential operation and self-calibration of axisymmetric Coriolis resonant gyroscopes. The proposed scheme actuates both modes of an axisymmetric gyroscope with two identical in-phase excitation signals, and senses both modes concurrently. This dual-mode actuation architecture utilizes the difference of the individual mode outputs to cancel out the common-mode bias terms, and provide rate-independent frequency split monitoring. The symmetry of the dual-mode architecture can be utilized to provide in-run scale factor calibration capability by mimicking the mechanical Coriolis force in the electrical domain, thereby providing a virtual electrical rotation to the gyroscope, to estimate the drift of the physical scale factor over time and temperature. The dual-mode architecture is demonstrated on a 2.625-MHz substrate-decoupled bulk acoustic wave gyroscope. The inherent bias cancellation provides sub10°/hr bias instability, with 1.4× improvement of angle random walk, as compared with the conventional single-mode actuation scheme. Benefiting from the in-run mode-matching capability, the dual-mode actuation scheme exhibits 45× reduction of bias drift over a temperature range of [10-80] °C. In-run scale factor calibration achieves 150× reduction of scale factor turn-on repeatability error down to 62 ppm, and over 100× reduction of the temperature drift of scale factor over [10-50] °C.
Effect of Collimator Selection on Tumor Detection for Dedicated Nuclear Breast Imaging Systems (2006)

The effect of collimation on the detection of small (<1 cm) breast tumors with dedicated nuclear breast imaging systems was determined. A breast phantom modeling tumors 4-9 mm in diameter was imaged with three dedicated systems (GE Medical Prototype CZT, Gamma Medica LumaGEM 3200 s, and Digirad 2020 tc), and a conventional gamma camera (Elscint Helix) using a variety of system-specific and generic collimators ranging from LEUHS to LEUHR. Acquisitions were performed using clinically relevant count densities determined from analysis of patient exams. Tumors were placed at depths of 1, 3, and 5 cm from the collimator in a 6-cm-thick breast, and tumor-to-background ratio was varied from 3:1 to 35:1. Tumor signal-to-noise ratio (SNR) was measured in each image. SNR measurements showed that an all-purpose or high sensitivity collimator is optimal for the detection of small tumors close to the collimator face. The three pixilated systems gave similar results and performed significantly better than the conventional gamma camera
Fabrication of front surface matched ultrasonic transducer array (1981)

First Page
Multilayer thin film silicon solar cells (1995)

New multilayer solar cells combine three innovations to produce a unique device structure which allows high efficiency cells to be designed on low quality material. The first innovation is the use of the multilayer structure itself, which provides the tolerance to low quality material. The second is the use of the well‐proven buried contact technology. The third innovation is a simple technique for connecting cells in series which relies on having grooves of opposite polarity either overlapping or in close proximity to each other. These three innovations combine to produce a manufacturing approach with a small number of processing steps able to produce a product with a high energy conversion efficiency using low quality starting material. The unit of production is a large module of approximately 1 m 2 in area rather than the smaller 100 cm 2 cells which are the present commercial norm .
A phase 1 study of p53MVA vaccine in combination with pembrolizumab. (2018)

206 Background: Mutations in the p53 gene are present in a majority of solid tumors, resulting in the accumulation of oncogenic and potentially immunogenic p53 protein within tumor cells. We have developed a genetically engineered Modified Vaccinia Ankara (MVA) virus to express wild type p53 transgene (p53MVA) as an immunotherapeutic strategy. We observed robust p53-specific CD8 + T cell responses which were further enhanced by anti-PD-1 treatment. This phase 1 study evaluates the safety and tolerability of the p53MVA vaccine in combination with pembrolizumab. Methods: Patients with non-small cell lung, head and neck squamous cell (HNSCC), hepatocellular (HCC), renal cell, melanoma, bladder, soft tissue sarcoma, triple-negative breast (TNBC), pancreatic (PDAC) and MSI high colorectal cancer failing or intolerant to standard treatment were eligible. Confirmation of p53 involvement by immunohistochemistry or mutational analysis was required for eligibility. A 3-at-risk rolling design was employed and patients received 5.6 x 10 8 pfu p53MVA for 3 doses in combination with 200 mg pembrolizumab for 7 doses every 3 weeks. Blood draws for immunological monitoring were obtained pre-treatment and up to week 19. Results: Two patients (TNBC and HNSCC) showed clinical benefit associated with durable p53-specific CD8 + T cell responses with gene expression pathway scores of T cell function and associated immune response categories elevated for more than 6 months. The TNBC patient had complete regression of cutaneous metastases and stable disease for > 6 months. Two patients (TNBC and PDAC) were on study for 35 and 9 weeks respectively; however, p53-specific T cells were not generated. Four patients (HCC, PDAC and 2 with TNBC) had rapidly progressive disease. Conclusions: Targeting p53 antigen associated with cancer using a viral vaccine p53MVA in combination with PD-1 blockade represents a novel immunotherapeutic approach capable of stimulating systemic immune responses and associated clinical benefit. Clinical trial information: NCT02432963.
Retroviruses in Human Gene Therapy (2005)

Abstract A retrovirus‐based gene transfer system consists of two components: the transfer vector, which harbours a foreign gene linked to elements needed for retroviral replication, and the packaging cell, which supplies the necessary retroviral proteins for transfer of the vector through a single round of viral replication. Most clinical protocols for gene therapy or gene marking using retroviral vectors are based upon gene transfer ex vivo followed by reimplantation of the target cells into the body.
A 0.18-$\mu$m CMOS Array Sensor for Integrated Time-Resolved Fluorescence Detection (2009)

This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 × 10(6) photons/cm(2) with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.
Development of coal-water slurries as boiler fuel (1981)

The development of slurries of coal and water as a boiler fuel replacing No. 6 fuel oil has been actively pursued at the Atlantic Research Corporation since 1976. Funding for this effort has been provided by the U.S. Department of Energy, the Electric Power Research Institute and by corporate funds. The name ARC-Coal has been selected for these slurries. Stable coal-water slurries with bond-dry coal loadings between 62% and 77% have been prepared, evaluated rheologically, and successfully burned in a one-million BTU/hr experimental furnace without the assistance of other fuels. The advantages, market, and economic factors of coal-water slurries are discussed. The properties of these slurries, including combustion results are reviewed. Also discussed is the pilot line used for processing barrel quantities of fuel and a pilot plant capable of processing 600 bb1/day, scheduled to go into operation in June, 1982. The goal of developing a slurry which can be pumped over considerable distances through a pipeline and also be burned as a fuel is suggested. 5 refs.
Sensorless pump operation estimation (2009)

Pumps are widely used in industrial applications, and they account for nearly a quarter of the electric energy consumption in the European industry. Pumps are often overdimensioned or they may be driven inefficiently, which causes unnecessary energy costs. If the pump drive is not equipped with appropriate measurements, inefficient pump operation may remain undetected for years and lead to a premature pump failure that also has an increasing effect on the pump drive's life cycle costs. Hence, pump operation monitoring may give a possibility for notable cost savings even if the pump is driven with a frequency converter. Since modern frequency converters provide estimates on the motor operation, they are a natural choice to monitor also the pump operation. In this paper, model-based estimation methods for the pump operating point are presented. Estimation methods are based on the internal measurements of the frequency converter, and therefore, external measurements are not necessary. Hence, the methods are a simple and cost-effective alternative to analyze pump operation: they can be applied in the control, optimization, and auditing purposes of a variable-speed-driven pump. Theoretical background is given for the methods, and they are evaluated with laboratory tests. According to the test measurements, estimation methods are applicable in auditing purposes.
Microwave irradiation synthesis and characterization of RGO‐AgNPs/polystyrene nanocomposites (2014)

Polystyrene and reduced graphene oxide/silver (PSTY/RGO/AgNPs) nanocomposites were prepared via an in situ bulk polymerization method using two different preparation techniques. In the first approach, a mixture of silver nitrate, hydrazine hydrate, and polystyrene containing graphene oxide (PSTY/GO) were reduced by microwave irradiation (MWI) to obtain R‐(PSTY‐GO)/AgNPs nanocomposites. In the second approach, a mixture of the (RGO/AgNPs) nanocomposite, which was produced via MWI, and STY monomers were polymerized using an in situ bulk polymerization method to obtain PSTY‐RGO/AgNPs nanocomposites. The two nanocomposites were compared and characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, X‐ray photoelectron spectroscopy, high‐resolution transmission electron microscopy, Differential scanning calorimetry, and thermogravimetric analysis. The results indicate that the nanocomposites obtained using the first approach, which involved MWI, exhibited a better morphology and dispersion with enhanced thermal stability compared to the nanocomposites prepared without MWI. POLYM. COMPOS., 35:2318–2323, 2014. © 2014 Society of Plastics Engineers
Analyzing the effects on the internal signal-to-noise ratio for bilateral hearing-aid systems configured for asymmetric processing (2013)

This paper investigates how bilateral hearing-aid systems configured to perform asymmetric processing affect the internal signal-to-noise ratio (SNR) in the auditory system. Here, an asymmetric hearing-instrument (HI) system is characterized by directional noise reduction in the instrument in one ear whereas the contra-lateral device is adjusted for omni mode processing. The Equalization and Cancellation model is used to evaluate the internal SNR of the auditory system. Two reference conditions were also created, a system with directionality in both HI, and one with omni-mode processing in both HI. A speaker was placed to the front, and another speaker was placed at the side. In the first experiment, the target was assumed to be in the front direction and the noise was assumed to be coming from the side. Here, it was shown that the asymmetric system provided the same SNR as the system with directionality in both HI. The noise and target positions were interchanged and the experiment was repeated. In this case, the asymmetric system provided similar SNR as the system with omni-mode processing in both HI, which for this test condition provided a better SNR than the system with directionality in both HI.
Simulation guidelines for incisions patterns on RF shields (2012)

Abstract A study is made and guidelines are found for optimizing slit patterns in radiofrequency (RF) shields. It is found that the gradient eddy currents can be effectively reduced by 1) placing a small number of azimuthal slits centered on “cold” bands outside of the central region of the RF shield and 2) restrictions on the lengths of the centralized axial slits. A simple “strip” model is presented to help understand the, perhaps counter‐intuitive, locations of the azimuthal cuts. Special consideration is given to hybrid MRI systems where there is a gap in the main‐magnet and gradient coils. © 2012 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 41B: 37–49, 2012
Treating Denim Fabrics with Trichoderma Reesei Cellulases (2000)

Cellulases are widely used to age denim fabrics. In this work the effects of three purified monocomponent cellulases, EG I, EG II, and CBH I, and two different cellulase mixtures produced by genetically modified strains of Trichoderma reesei are compared for stone washing denim fabrics. Stone washing effects are evaluated by analyzing the soluble reducing sugars, absorbance, and lightness values of the treatment solutions. The prop erties of denim swatches are evaluated by reflectance units and by a panel. Purified cellulase EG II is most effective at removing color from denim, producing a good stone washing effect with the lowest hydrolysis level. Treatment with CBH I does not produce any stone washing effect, even at high enzyme dosages. The commercial cellulase Ecostone® L produces a good stone washing effect, but the experimental cellulase mixture Cellulase B removes color only with the highest enzyme dosage, i.e., when the amount of EGS in the mixture is high enough.
DNA Vaccines for Prostate Cancer (2012)

Delivery of plasmid DNA encoding an antigen of interest has been demonstrated to be an effective means of immunization, capable of eliciting antigen-specific T cells. Plasmid DNA vaccines offer advantages over other anti-tumor vaccine approaches in terms of simplicity, manufacturing, and possibly safety. The primary disadvantage is their poor transfection efficiency and subsequent lower immunogenicity relative to other genetic vaccine approaches. However, multiple preclinical models demonstrate anti-tumor efficacy, and many efforts are underway to improve the immunogenicity and anti-tumor effect of these vaccines. Clinical trials using DNA vaccines as treatments for prostate cancer have begun, and to date have demonstrated safety and immunological effect. This review will focus on DNA vaccines as a specific means of antigen delivery, advantages and disadvantages of this type of immunization, previous experience in preclinical models and human trials specifically conducted for the treatment of prostate cancer, and future directions for the application of DNA vaccines to prostate cancer immunotherapy.
A minimum-work weighted fair queuing algorithm for guaranteed end-to-end and quality-of-service in packet networks (2009)

Emerging applications in multimedia communications and Virtual Private Networks (VPNs) require data networks to provide Quality-of-Service (QoS) guarantees, such as delay and/or jitter bounds, to individual packet flows. Providing such guarantees can be achieved by link scheduling mechanisms along the path of these packets. Among the many packet-scheduling techniques proposed for this problem, Weighted Fair Queuing (WFQ) offers the best delay and fairness guarantees. However, all previous work on WFQ has been focused on developing inefficient approximations of the scheduler because of perceived scalability problems in the WFQ computation. This thesis proves that the previously well accepted O(N) time-complexity for WFQ implementation, where N is the number of active flows handled by the scheduler, is not true. The other key contribution of the thesis is a novel Minimum- Work Weighted Fair Queuing (MW-WFQ) algorithm which is an 0(1) algorithm for implementing WFQ. In addition, the thesis presents several performance studies demonstrating the power of the proposed algorithm in providing precise delay bounds to a large number of sessions with diverse QoS requirements, whereas other well known scheduling techniques have failed to provide the same guarantees for the same set of sessions.
Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen<i>Stereocaulon alpinum</i> (2018)

The first total syntheses of the natural products lobaric acid (1) and its derivatives isolated from the Antarctic lichen Stereocaulon alpinum are reported in this study. Lobarin (3), with a pseudodepsidone structure, was synthesized first in 11 steps by utilizing an Ullmann aryl ether coupling reaction, and lobaric acid was synthesized in an additional three steps by a seven-membered lactonization reaction. Various derivatives were also obtained from the prepared lobaric acid, and the synthetic compounds exhibited significant PTP1B inhibitory activities.
Computer-Automated Tinnitus Assessment: Noise-Band Matching, Maskability, and Residual Inhibition (2013)

This study may represent the first time that NBM, MML, and RI audiometric testing results have been obtained entirely through a self-contained, computer-automated system designed specifically for use in the clinic. Future plans include refinements to achieve greater testing efficiency.
Nitrogen oxides (NOx) influence on sulfite oxidation and scaling in lime/limestone flue gas desulfurization (FGD) systems (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrogen oxides (NOx) influence on sulfite oxidation and scaling in lime/limestone flue gas desulfurization (FGD) systemsHarvey S. Rosenberg and Henry M. GrottaCite this: Environ. Sci. Technol. 1980, 14, 4, 470–472Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/es60164a011https://doi.org/10.1021/es60164a011research-articleACS PublicationsRequest reuse permissionsArticle Views303Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Single‐chain antibodies for the conformation‐specific blockade of activated platelet integrin α <sub>IIb</sub> β <sub>3</sub> designed by subtractive selection from naïve human phage libraries (2004)

Binding of fibrinogen to platelet integrin alphaIIbbeta3 mediates platelet aggregation, and thus inhibition of alphaIIbbeta3 represents a powerful therapeutic strategy in cardiovascular medicine. However, the currently used inhibitors of alphaIIbbeta3 demonstrate several adverse effects like thrombocytopenia and bleeding, which are associated with their property to bind to non-activated alphaIIbbeta3. To circumvent these problems, we designed blocking single-chain antibody-fragments (scFv) that bind to alphaIIbbeta3 exclusively in its activated conformation. Two naive phage libraries were created: a natural phage library, based on human lymphocyte cDNA, and a synthetic library, with randomized VHCDR3. We performed serial rounds of subtractive panning with depletion on non-activated and selection on activated alphaIIbbeta3, which were provided on resting and ADP-stimulated platelets and CHO cells, expressing wild-type or mutated and thereby activated alphaIIbbeta3. In contrast to isolated, immobilized targets, as generally used for phage display, this unique cell-based approach for panning allowed the preservation of functional integrin conformation. Thereby, we obtained several scFv-clones that demonstrated exclusive binding to activated platelets and complete inhibition of fibrinogen binding and platelet aggregation. Interestingly, all activation-specific clones contained an RXD pattern in the HCDR3. Binding studies on transiently expressed point mutants and mouse-human domain-switch mutants of alphaIIbbeta3 indicate a binding site similar to fibrinogen. In conclusion, we generated human activation-specific scFvs against alphaIIbbeta3, which bind selectively to activated alphaIIbbeta3 and thereby potently inhibit fibrinogen binding to alphaIIbbeta3 and platelet aggregation.
Think Globally, Act Locally: A Deep Neural Network Approach to High-Dimensional Time Series Forecasting (2019)

Forecasting high-dimensional time series plays a crucial role in many applications such as demand forecasting and financial predictions. Modern datasets can have millions of correlated time-series that evolve together, i.e they are extremely high dimensional (one dimension for each individual time-series). There is a need for exploiting global patterns and coupling them with local calibration for better prediction. However, most recent deep learning approaches in the literature are one-dimensional, i.e, even though they are trained on the whole dataset, during prediction, the future forecast for a single dimension mainly depends on past values from the same dimension. In this paper, we seek to correct this deficiency and propose DeepGLO, a deep forecasting model which thinks globally and acts locally. In particular, DeepGLO is a hybrid model that combines a global matrix factorization model regularized by a temporal convolution network, along with another temporal network that can capture local properties of each time-series and associated covariates. Our model can be trained effectively on high-dimensional but diverse time series, where different time series can have vastly different scales, without a priori normalization or rescaling. Empirical results demonstrate that DeepGLO can outperform state-of-the-art approaches; for example, we see more than 25% improvement in WAPE over other methods on a public dataset that contains more than 100K-dimensional time series.
Embedded Topics in the Stochastic Block Model (2022)

Communication networks such as emails or social networks are now ubiquitous and their analysis has become a strategic field. In many applications, the goal is to automatically extract relevant information by looking at the nodes and their connections. Unfortunately, most of the existing methods focus on analysing the presence or absence of edges and textual data is often discarded. However, all communication networks actually come with textual data on the edges. In order to take into account this specificity, we consider in this paper networks for which two nodes are linked if and only if they share textual data. We introduce a deep latent variable model allowing embedded topics to be handled called ETSBM to simultaneously perform clustering on the nodes while modelling the topics used between the different clusters. ETSBM extends both the stochastic block model (SBM) and the embedded topic model (ETM) which are core models for studying networks and corpora, respectively. The inference is done using a variational-Bayes expectation-maximisation algorithm combined with a stochastic gradient descent. The methodology is evaluated on synthetic data and on a real world dataset.