gebhart/patrepeval huggingface dataset:
A Service Discovery Mechanism with Load Balance Issue in Decentralized Peer-to-Peer Network (2005)

Peer-to-peer systems (P2P) have attracted much current attention as a popular way to share huge volumes of resources directly within peers. Efficient content search and load balancing are both important research issues in P2P environments, especially in those without centralized global indexes. Although a number of content search schemes are known to alleviate these problems, they cannot provide flexible object searches while balancing the load for content demand in P2P networks, thereby resulting in severe load imbalance and consequently increased user response times. In this paper, we tend to address these problems that take advantage of current domain name server (DNS) architecture by harnessing all available resources in the P2P networks and balance the load without decreasing user response time. We proposed a novel decentralized service discovery mechanism by creating an agent called P2P registry (P2PReg) as a middleware within DNS and peers. In our scheme, each peer is able to register and discover desirable services automatically through current DNS within a short duration in an efficient way with the help of P2PReg. The proposed method does not only perform least searching time and low bandwidth but also balances load in P2P systems in order to avoid hot spot (refers to a node which receives a large volume of requests in rapidly) problems naturally. It is obvious that the more replicas there are, the better the media delivery quality of the specific content object is. We also present the results of simulation work to validate the viability of our approach. Our simulation study showed that serving data discovery over local search is indeed effective in improving the system performance significantly.
Thermomechanical noise limits on parametric sensing with nanomechanical resonators (2005)

Measuring and monitoring the dynamic parameters of a nanomechanical resonator, in particular the resonance frequency, has received significant attention recently, in part due to the possibility of very sensitive, fast and precise mass sensing. Added mass can include chemisorbed or physisorbed metals or organic molecules, and if sufficiently high sensitivity, dynamic range and detector speed can be achieved, they could have applications in, e.g., proteomics. Here, I investigate some of the fundamental limits to mass sensing in such resonators, discussing the limits imposed by thermomechanical noise on both the linear operating regime of a simple harmonic oscillator, and the equivalent limits on nonlinear parametric amplifiers used as parametric sensors. The model system is a cantilevered flexural resonator, but the results apply equally well (in most cases) to doubly clamped or torsional resonant structures as well.
FPGA based Fuzzy Logic Control for Single Phase Multilevel Inverter (2010)

A single phase cascaded inverter consisting of two full bridges creates a five level AC output voltage. Due to switch combination redundancies, there are certain degrees of freedom to generate the five level AC output voltage. A single phase Pulse Width Modulation (PWM) Multil Level Inverter (MLI) produces AC output voltage of desired magnitude and frequency. The purpose of voltage controller for the inverter is to produce regulated output voltage with low distortion under all loading conditions. In this paper, the objective of reducing the THD of output of the chosen five level cascaded inverter under steady-state as well as set point tracking with fast transient response are approached from control point of view. A Fuzzy Logic Controller (FLC) is developed using Matlab-Simulink and implemented using Field Programmable Gate Array (FPGA) for the chosen inverter. For comparison purposes, a PI controller is also developed and implemented. The results are presented and analysed.
Translational assessment of mitochondrial dysfunction of pancreatic cancer from in vitro gene microarray and animal efficacy studies, to early clinical studies, via the novel tumor-specific anti-mitochondrial agent, CPI-613. (2014)

The dysfunctional mitochondria of pancreatic cancer cells was translationable from in vitro gene alteration and animal tumor model studies to patients with advanced Stage IV pancreatic cancer, as reflected by the anti-cancer activities of the tumor-specific anti-mitochondrial agent, CPI-613, in these studies.
Unconventional plastic optical fiber design for very short multimode fiber link (2019)

We introduce a graded-index plastic optical fiber (GI POF) design for very short-distance household applications, in which the transmission quality is predominantly determined by system noise rather than the loss and bandwidth. The developed GI POF has strong mode coupling with low accompanying scattering loss, which is closely related to the specific microscopic heterogeneities in the core material. Such characteristic mode coupling significantly decreases reflection noise, improving the transmission quality compared with silica GI multimode fiber (MMF) for lengths below 30 m. Moreover, in the GI POF link, the transmission quality tends to improve with increasing fiber length, despite the increased loss and decreased bandwidth. This feature suggests that the system noise can be controlled by the microscopic heterogeneous properties of the GI POF for a very short MMF link, where the fiber loss and bandwidth are sufficiently low and high, respectively. This unconventional concept for optical-fiber design can advance fiber-optic communication in emerging applications in households located near optical network terminals.
Development of commercial vehicle maintenance management information system (2012)

In order to improve the efficiency of enterprise maintenance management, on the basis of user needs analysis of the transportation enterprises and vehicle maintenance enterprises, taking three-tier C/S architecture, ADO database access technique, Visual Studio 2010 and SQL Server 2008, commercial vehicle maintenance management information system is developed. Function modules of the system designed are user management, vehicle data management, due tip, vehicle technical condition inquiry. Specific system functions developed are as following: vehicle basic information management, vehicle maintenance records management, vehicle technical rank evaluation management, vehicle complete maintenance management, vehicle operation records management, vehicle technical condition inquiry. Running the developed system shows that the management information system has steady performances, and could meet the needs of enterprise vehicle maintenance management.
A theoretical study of the disproportionation reactions of diimide (N2H2) species (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA theoretical study of the disproportionation reactions of diimide (N2H2) speciesDaniel J. PastoCite this: J. Am. Chem. Soc. 1979, 101, 23, 6852–6857Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/ja00517a010https://doi.org/10.1021/ja00517a010research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
En direct de l'AACR : compte rendu du 18 avril (2016)

Deux « major symposia » etaient consacres a l’immunotherapie ce lundi. Celui du matin s’interessait aux mecanismes de resistance primaire ou secondaire a l’immunotherapie, celui de l’apres-midi plus particulierement a la genome-guided immunotherapy que j’ai presentee hier. J’ai retenu le matin la presentation de Jedd Wolchock (du Memorial Sloan Kettering Cancer Center, New York), consacree a l’utilisation de combinaisons therapeutiques et intitulee : Combinations using checkpoint blockade as one means to address resistance. Wolchock est convaincu que l’avenir de l’immunotherapie reside dans les combinaisons rationnelles : le blocage simultane des voies inhibitrices CTLA-4 et PD1 a deja montre son efficacite, avec un taux de reponses objectives de 58% et de reponses completes de 11,5% obtenu par l’association ipilimumab–nivolumab dans le melanome malin. Agir simultanement sur les voies inhibitrices bien connues et bien maitrisees, grâce aux anticorps antagonistes des recepteurs de co-inhibition et de leurs ligands (les proteines B7), et sur les voies stimulatrices, moins bien connues, est certainement prometteur et pourrait donner un degre de synergie superieur. Les voies stimulatrices sont assurees par des ligands de la superfamille du TNF (Tumor necrosis factor), que l’on appelle de facon generique les TNFSF, et des recepteurs de la superfamille correspondante appelee TNFRSF.
Adaptive motion estimation algorithm for MPEG-4 video coding (2003)

In this paper, we propose an efficient motion estimation algorithm for MPEG-4 video coding in real-time application. The proposed algorithm first estimates initial motion vector using motion vector information in the previous frame. Based on the sum of absolute difference of the initial motion vector, it selects appropriate motion estimation algorithm. The proposed method shows similar performance with the full-search block matching algorithm (FSBMA), while reduces computational complexity greatly. We implemented and simulated the proposed algorithm on embedded DSP system. Simulation results show that the proposed algorithm shows superior performance with smaller computational complexity compared to previous fast search motion estimation algorithms.
Evaluation of an adaptive traffic control technique with underlying system changes (1995)

A key problem in traffic engineering is the optimization of the flow of vehicles through a given road network. Improving the timing of the traffic signals at intersections in the network is generally the most powerful and cost-effective means of achieving this goal. Recent efforts have resulted in the development of a fundamentally different approach for optimal centralized signal timing control that eliminates the need for an open-loop model of the traffic network dynamics. The approach is based on a neural network (NN) serving as the basis for the control law, with the internal NN weight estimation occurring real-time in closed-loop mode via the simultaneous perturbation stochastic approximation (SPSA) algorithm. The paper investigates the application of such a non-network-model-based approach and illustrates the approach through a simulation on a nine-intersection, mid-Manhattan, New York network. The simulated traffic network contains varying short and long-term congestion behavior and short-term stochastic, nonlinear effects. The approach results in a net 10% reduction in vehicle wait time relative to the performance of the existing, in-place strategy.
Thermomechanical Characterization of SiC/SiC Ceramic Matrix Composites in a Combustion Facility (2019)

A combustion facility which includes uniaxial mechanical loading was implemented that enables environmental conditions more akin to jet engine environments compared to conventional static environment tests. Two types of woven SiC/SiC ceramic matrix composites (CMCs), melt-infiltrated (MI) and chemical vapor infiltrated (CVI), were subjected to fatigue loading in the combustion facility and under isothermal furnace conditions. Some CVI test coupons were coated with a multilayer environmental barrier coating (EBC) of mullite + ytterbium monosilicate using slurry infiltration process to demonstrate the performance with a coating. Combustion conditions were applied using a high velocity oxy fuel gun on the front side of the specimen and mechanical loading was applied using a horizontal hydraulic MTS machine. All the specimens considered were subjected to tension-tension fatigue loading at 100 MPa, stress ratio of 0.1 and specimen front-side surface temperature of 1200 ± 20 °C. Nondestructive evaluation (NDE) methods, such as electrical resistance (ER), was used as an in-situ health monitoring technique. Similar fatigue tests were performed in an isothermal furnace for comparison. A much lower fatigue life was observed for the uncoated specimens tested under combustion conditions in comparison to isothermal furnace condition. This difference in fatigue life was attributed to damage associated with added thermal stress due to the thermal gradient and higher rate of oxidative embrittlement due to the presence of high velocity combustion gases in the combustion environment. EBC coating increased the fatigue life in combustion environment. However, EBC coated specimens experienced spallation in the high-velocity flame due to the presence of micro cracks in the coating surface. Fracture surfaces of the failed specimens were investigated under the scanning electron microscope (SEM) to determine the extent of oxidation and damage.
Improved Recovery After Myocardial Ischemic Infarction by Copper Supplementation (2015)

Depressed angiogenesis due to ischemic injury leads to myocardial infarction. Copper (Cu) is involved in angiogenesis and ischemia causes copper loss in the heart. The present study was undertaken to test the hypothesis that Cu supplementation improves myocardial angiogenesis, leading to regression of myocardial ischemic infarction in Rhesus monkey model. Coronary artery ligation was used to produce myocardial ischemia and the monkeys developed myocardial infarction 4 weeks after ischemia. A newly developed ultrasound contrast microbubble composed of Cu-albumin coated structure was used to specifically deliver Cu into the infarct area. The treatment was performed twice a week for 4 weeks. This procedure effectively increased Cu concentrations in the infarct area and activated the angiogenesis factors including vascular endothelial growth factor (VEGF), VEGF receptor-1 (VEGFR-1), and other relevant factors. Along with these changes, myocardial infarct size was significantly decreased and the density of myocardial microvessels was significantly increased. In addition, cardiac function was significantly recovered, as evidenced by increased ejection fraction (EF) values and decreased end-systolic volume (ESV) measured by echocardiography. This study thus demonstrated that Cu supplementation improved cardiac structural and functional recovery after ischemic infarction. Supported by National Science Foundation of China (81230004 and 81300109).
PASSOS: a different approach for assignment and scheduling for power, area and speed optimization in high-level synthesis (2002)

This paper presents a high-level (behavioral) synthesis method that takes advantage of digit-serial arithmetic to minimize power consumption, transistor counts and delays. Genetic algorithms are used for simultaneous scheduling and assignment to obtain significant savings and improvements compared with parallel (32-bit) implementations and/or the best results reported in the literature.
Asymmetric Diels–Alder Reactions of α,β‐Unsaturated Aldehydes Catalyzed by a Diarylprolinol Silyl Ether Salt in the Presence of Water (2008)

Water, water, everywhere: The title reaction predominantly affords the exo isomer with excellent enantioselectivity (see scheme; TMS=trimethylsilyl). The synthesis can be carried out without organic solvents and provides the products by distillation. Water increases the rate and enantioselectivity of the reaction. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z801408_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Relationships between fish and supralittoral vegetation in nearshore marine habitats (2006)

1. This study was conducted to determine whether there were significant differences in the species richness and community composition of fish assemblages in coastal nearshore habitats with differing compositions of supralittoral vegetation. 2. We sampled fish assemblages and conducted supralittoral vegetation surveys at 27 beaches on the west coast of Vancouver Island, British Columbia. Thirteen of the beaches had supralittoral vegetation characteristic of old-growth coastal forests and 14 had been previously subjected to logging or other disturbances. 3. Physical features (e.g. substrate, salinity, etc.) were recorded at each beach to determine whether there were significant associations between supralittoral vegetation and beach characteristics as well as between beach characteristics and fish assemblages. 4. Across all 27 beaches, 1832 individuals of 31 species of nearshore fish were collected, primarily juvenile cottids and salmonids. Mean species richness did not differ between beaches with old-growth versus secondary-growth supralittoral vegetation; however, a higher cumulative number of species was found at beaches with old-growth supralittoral vegetation. 5. Canonical Correspondence Analysis (CCA) showed that beach characteristics and supralittoral vegetation were not significantly associated. Separate CCA for fish associations with beach characteristics and fish associations with supralittoral vegetation explained ∼55% of the variance in fish assemblage composition, suggesting that fish assemblage composition is significantly affected by substrate, submerged vegetation, and physico-chemical conditions as well as by the community composition of vegetation in adjacent supralittoral habitats. 6. Specifically, we found associations between supralittoral vegetation and penpoint gunnels (Apodichthys flavidus Girard), tidepool sculpins (Oligocottus maculosus Girard), Pacific staghorn sculpins (Leptocottus armatus Girard), arrow gobies (Clevelandia ios Jordan and Gilbert), shiner perch (Cymatogaster aggregata Gibbons) and kelp perch (Brachyistius frenatus Gill). Juvenile chum (Oncorhynchus keta Walbaum) and coho (Oncorhynchus kisutch Walbaum) salmon were strongly associated with supralittoral vegetation characteristic of mature coastal forests such as mosses and western red cedar (Thuja plicata) suggesting that some nearshore fish species may be affected by processes originating in terrestrial ecosystems. 7. Our results suggest that some nearshore fish species may be affected by removal of supralittoral vegetation. Copyright © 2006 John Wiley & Sons, Ltd.
Active uptake and extravesicular storage of m-iodobenzylguanidine in human neuroblastoma SK-N-SH cells. (1989)

Radio-iodinated m-iodobenzylguanidine (MIBG), an analogue of the neurotransmitter norepinephrine (NE), is increasingly used in the diagnosis and treatment of neural crest tumors. Active uptake and subsequent retention of MIBG and NE was studied in human neuroblastoma SK-N-SH cells. Neuron-specific uptake of [125I]MIBG and [3H]NE saturated at extracellular concentration of 10(-6) M and exceeded by 20-30-fold that by passive diffusion alone. A minimum of 50% of accumulated MIBG remained permanently stored but the SK-N-SH cells were incapable of retaining recaptured [3H]NE. [125I]MIBG was displaced from intracellular binding sites by unlabeled MIBG with 10-fold higher potency than by unlabeled NE. MIBG stored in SK-N-SH cells was insensitive to depletion by the inhibitor of granular uptake reserpine (RSP) and was not precipitated in a granular fraction by differential centrifugation. Only few electron-dense granules were found in these cells by electron microscopy. In contrast, MIBG storage in PC-12 pheochromocytoma cells which contained many storage granules, was sensitive to RSP and part of accumulated drug was recovered in a granular fraction. Accordingly, storage of MIBG in the SK-N-SH neuroblastoma cells is predominantly extravesicular and thus essentially different from that of biogenic amines in normal adrenomedullary tissue or in pheochromocytoma tumors, while sharing with these tissues a common mechanism of active uptake.
Micromachined analyzers on a silicon chip (1994)

For an example of a silicon-based micromachined analyzer, we describe a combined PO2, PCO2, and pH sensor designed for extracorporeal blood gas monitoring. The clinically well-accepted amperometric (PO2) and potentiometric (PCO2, pH) sensing principles are used, realized in a planar and miniaturized form on a single silicon chip (6 x 22 mm). The transducer part of the chip is fabricated by standard silicon technology. Polyacrylamide and polysiloxane polymeric layers, which are used as internal electrolyte and gas-permeable membrane, respectively, are deposited and patterned by photopolymerization. The entire sensor is fabricated on the wafer level by using integrated-circuit-compatible processes, thus allowing mass production. By integrating a flow-through channel directly on the chip, the sample size and the reagent consumption are substantially reduced. The device was characterized in aqueous solutions and in blood intended for transfusion. The sensor has a typical sensitivity of 0.36 nA/mmHg (PO2), -39 mV/decade (PCO2), and 51 mV/pH (pH); low drift; and a functional lifetime of > 2 months. The analytical precision in the physiologically expected range is better than 2 mmHg for the PO2 and PCO2 sensor, and 0.02 pH unit for the pH sensor.
Antioxidant and Immuno-Enhancing Effects of Echinacea purpurea (2004)

We studied the protective effects of Echinacea purpurea against radiation by evaluating changes in the peripheral blood cell count and peripheral blood antioxidant activity. E. purpurea administration had a suppressive effect on radiation-induced leukopenia, especially on lymphocytes and monocytes, and resulted in a faster recovery of blood cell counts. Mouse peripheral blood antioxidant activity was increased by E. purpurea, and a relationship between the suppressive effect on radiation-induced leukopenia and the antioxidant effect was suggested. Furthermore, we reviewed the evidence of augmentation of found in this study humoral immunity. The effects of immune activation by E. purpurea were investigated by measuring total immunoglobulin (IgG, IgM). The radioprotective effects of immune activation by E. purpurea were investigated by measuring T lymphocyte subsets in the peripheral blood of mice following whole-body irradiation. E. purpurea activates macrophages to stimulate IFN-gamma production in association with the secondary activation of T lymphocytes, resulting in a decrease in IgG and IgM production. Cytokines released from macrophages in mouse peripheral blood after E. purpurea administration activated helper T cells to proliferate. In addition, it is reported that activated macrophages in association with the secondary T lymphocyte activation increases IFN-gamma production and stimulates proliferation of cytotoxic T cells and suppressor T cells. We think that CD 4 and CD 8 subsets were more immunologically enhanced by E. purpurea than helper T cells and suppressor T cell these results reflect activation. In addition, we think that these results reflect cell-mediated immune responses.