gebhart/patrepeval huggingface dataset:
N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease (2015)

Huntington's disease (HD) is a neurodegenerative disorder, involving psychiatric, cognitive and motor symptoms, caused by a CAG-repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. Oxidative stress and excitotoxicity have previously been implicated in the pathogenesis of HD. We hypothesized that N-acetylcysteine (NAC) may reduce both excitotoxicity and oxidative stress through its actions on glutamate reuptake and antioxidant capacity. The R6/1 transgenic mouse model of HD was used to investigate the effects of NAC on HD pathology. It was found that chronic NAC administration delayed the onset and progression of motor deficits in R6/1 mice, while having an antidepressant-like effect on both R6/1 and wild-type mice. A deficit in the astrocytic glutamate transporter protein, GLT-1, was found in R6/1 mice. However, this deficit was not ameliorated by NAC, implying that the therapeutic effect of NAC is not due to rescue of the GLT-1 deficit and associated glutamate-induced excitotoxicity. Assessment of mitochondrial function in the striatum and cortex revealed that R6/1 mice show reduced mitochondrial respiratory capacity specific to the striatum. This deficit was rescued by chronic treatment with NAC. There was a selective increase in markers of oxidative damage in mitochondria, which was rescued by NAC. In conclusion, NAC is able to delay the onset of motor deficits in the R6/1 model of Huntington's disease and it may do so by ameliorating mitochondrial dysfunction. Thus, NAC shows promise as a potential therapeutic agent in HD. Furthermore, our data suggest that NAC may also have broader antidepressant efficacy.
Agency of Life, Entropic Gravity and Phenomena Attributed to “Dark Matter” (2017)

Entropic gravity theories propose that spacetime and gravity emerge from quantum information entanglements. Vacuum spacetime emerges in the ground state and its area law for entanglement entropy is due to short-range entanglement of neighbouring microscopic degrees of freedom. Matter changes the entanglement entropy in this vacuum and leads to Einstein gravity. Additionally, in a positive dark energy de Sitter Universe, where each conscious agent has a cosmological horizon, a volume law contribution to entanglement entropy is divided evenly over the same degrees of freedom and is caused by long-range entanglement. I propose these complementary shortrange and long-range entanglement contributions form a nested small-world network which provides the topological quantum computing foundation for relativistic multi-agent correlations which weave together a universal physics of Nature. The volume law contribution to entanglement entropy surpasses the area law for entanglement entropy at an agent’s cosmological horizon. Verlinde interprets gravitational “dark matter” phenomena as polymer-like memory effects caused by the volume contribution to the entanglement entropy. I propose these phenomena are instead multi-agent quantum computational consensus effects due to an equivalent volume contribution to the entanglement entropy. Life is correlated with its environment. Phenomena attributed to unseen “dark matter” particles are proposed here to be founded upon nested observer halos, “spheres of influence or correlation”, caused by the consensus Agency of Life. Suitable cosmological conditions for earliest Life in the Universe occurred some 10 billion years ago and older galaxies do not exhibit “dark matter” phenomena. Also, galactic rotation curves flatten beyond their high-radiation centres, due to astrobiology and the Agency of Life living in outlying low-radiation habitable zones. Where baryonic matter is in motion, then the Agency of Life stores its baryonic matter-lagging memory in skewed trails of apparent “dark matter” phenomena in spacetime.
Range sensing by projecting multi-slits with random cuts (2003)

A method is described for acquiring range data by projecting a single pattern of multiple slits. To obtain three-dimensional data by projecting a single pattern, certain codes for identifying each slit must be contained in the pattern. In addition, if the characteristics of the code embedded in the pattern are not affected by the change of relations between a position of a camera and that of a pattern projector, arbitrariness in positions of both the camera and the projector can be allowed. Random dots are used to identify each slit. The random dots are given as randomly distributed cuts on each slit. Thus, each slit is divided into many small line segments, and, using these segments as features, stereo matching is carried out to obtain three-dimensional data. Using adjacent relations among slit segments, segment pairs, whose adjacent segments also correspond to each other, are extracted and considered to be correct matches. From the resultant matches, the correspondence is propagated by utilizing the adjacency relationships to get an entire range image.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Crystal Structure of the Allergen Equ c 1 (2000)

The three-dimensional structure of the major horse allergen Equ c 1 has been determined at 2.3 A resolution by x-ray crystallography. Equ c 1 displays the typical fold of lipocalins, a beta-barrel flanked by a C-terminal alpha-helix. The space between the two beta-sheets of the barrel defines an internal cavity that could serve, as in other lipocalins, for the binding and transport of small hydrophobic ligands. Equ c 1 crystallizes in a novel dimeric form, which is distinct from that observed in other lipocalin dimers and corresponds to the functional form of the allergen. Binding studies of point mutants of the allergen with specific monoclonal antibodies raised in mouse and IgE serum from horse allergic patients allowed to identify putative B cell antigenic determinants. In addition, total inhibition of IgE serum recognition by a single specific monoclonal antibody revealed the restricted nature of the IgE binding target on the molecular surface of Equ c 1.
Mechanical hand for gripping objects (1980)

End effector serves as hand for remote manipulator spacecraft system to grasp objects of various sizes. Device has built in flexible wrist joint cartilage for increased gripping force without significant strain on mechanical connections.
Police Complaint Management System using Blockchain Technology (2020)

The criminal activities in India are increasing at a rapid rate. Many of these activities go unreported. Even after having an online portal for the police for storing FIRs and NCRs, most of the FIRs are handwritten as a traditional practice. In most of the cases, the complainant has to be present in the police station to file a cognizable offense. An effective system for e-governance was started in 2009 named Crime and Criminal Tracking Network and Systems (CCTNS) for the entire country. However, it is a centralized system for a particular state. Thus there is a need for a completely decentralized system for assuring that there is no central point of failure in the system and complaints are managed securely protected from unauthorized access. Our aim is to propose a blockchain-based solution to manage complaints against both cognizable and non-cognizable offenses. The FIR filed by the police will be encrypted, stored in the IPFS and hash is added to the blockchain network. If the police decide not to file the FIR under pressure or deny receiving any complaint, then the complainant will have strong proof against him/her as the complaint along with its timestamp was stored on the blockchain network. Having all the records stored in an immutable database would remove any chances of the FIR/NCR being tampered and going unnoticed.
CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease (2009)

CD39/ENTPD1 hydrolyzes proinflammatory nucleotides to generate adenosine. As purinergic mediators have been implicated in intestinal inflammation, we hypothesized that CD39 might protect against inflammatory bowel disease. We studied these possibilities in a mouse model of colitis using mice with global CD39 deletion. We then tested whether human genetic polymorphisms in the CD39 gene might influence susceptibility to Crohn's disease. We induced colitis in mice using Dextran Sodium Sulfate (DSS). Readouts included disease activity scores, histological evidence of injury, and markers of inflammatory activity. We used HapMap cell lines to find SNPs that tag for CD39 expression, and then compared the frequency of subjects with high vs. low CD39-expression genotypes in a case-control cohort for Crohn's disease. Mice null for CD39 were highly susceptible to DSS injury, with heterozygote mice showing an intermediate phenotype compared to wild type (WT). We identified a common SNP that tags CD39 mRNA expression levels in man. The SNP tagging low levels of CD39 expression was associated with increased susceptibility to Crohn's disease in a case-control cohort comprised of 1,748 Crohn's patients and 2,936 controls (P = 0.005-0.0006). Our data indicate that CD39 deficiency exacerbates murine colitis and suggest that CD39 polymorphisms are associated with inflammatory bowel disease in humans.
Environmental robustness in automatic speech recognition (2002)

Initial efforts to make Sphinx, a continuous-speech speaker-independent recognition system, robust to changes in the environment are reported. To deal with differences in noise level and spectral tilt between close-talking and desk-top microphones, two novel methods based on additive corrections in the cepstral domain are proposed. In the first algorithm, the additive correction depends on the instantaneous SNR of the signal. In the second technique, expectation-maximization techniques are used to best match the cepstral vectors of the input utterances to the ensemble of codebook entries representing a standard acoustical ambience. Use of the algorithms dramatically improves recognition accuracy when the system is tested on a microphone other than the one on which it was trained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Intestinal, segmented, filamentous bacteria (1992)

Segmented, filamentous bacteria (SFBs) are autochthonous, apathogenic bacteria, occurring in the ileum of mice and rats. Although the application of formal taxonomic criteria is impossible due to the lack of an in vitro technique to culture SFBs, microbes with a similar morphology, found in the intestine of a wide range of vertebrate and invertebrate host species, are considered to be related. SFBs are firmly attached to the epithelial cells of the distal ileal mucosa, their preferential ecological niche being the epithelium covering the Peyer's patches. Electron microscopic studies have demonstrated a considerable morphological diversity of SFBs, which may relate to different stages of a life cycle. Determinants of SFB colonization in vivo are host species, genotypical and phenotypical characteristics of the host, diet composition, environmental stress and antimicrobial drugs. SFBs can survive in vitro incubation, but do not multiply. On the basis of their apathogenic character and intimate relationship with the host, it is suggested that SFBs contribute to development and/or maintenance of host resistance to enteropathogens.
Development and Validation of an Ultradeep Next-Generation Sequencing Assay for Testing of Plasma Cell-Free DNA from Patients with Advanced Cancer (2017)

<b>Purpose:</b> Tumor-derived cell-free DNA (cfDNA) in plasma can be used for molecular testing and provide an attractive alternative to tumor tissue. Commonly used PCR-based technologies can test for limited number of alterations at the time. Therefore, novel ultrasensitive technologies capable of testing for a broad spectrum of molecular alterations are needed to further personalized cancer therapy.<b>Experimental Design:</b> We developed a highly sensitive ultradeep next-generation sequencing (NGS) assay using reagents from TruSeqNano library preparation and NexteraRapid Capture target enrichment kits to generate plasma cfDNA sequencing libraries for mutational analysis in 61 cancer-related genes using common bioinformatics tools. The results were retrospectively compared with molecular testing of archival primary or metastatic tumor tissue obtained at different points of clinical care.<b>Results:</b> In a study of 55 patients with advanced cancer, the ultradeep NGS assay detected 82% (complete detection) to 87% (complete and partial detection) of the aberrations identified in discordantly collected corresponding archival tumor tissue. Patients with a low variant allele frequency (VAF) of mutant cfDNA survived longer than those with a high VAF did (<i>P</i> = 0.018). In patients undergoing systemic therapy, radiological response was positively associated with changes in cfDNA VAF (<i>P</i> = 0.02), and compared with unchanged/increased mutant cfDNA VAF, decreased cfDNA VAF was associated with longer time to treatment failure (TTF; <i>P</i> = 0.03).<b>Conclusions:</b> Ultradeep NGS assay has good sensitivity compared with conventional clinical mutation testing of archival specimens. A high VAF in mutant cfDNA corresponded with shorter survival. Changes in VAF of mutated cfDNA were associated with TTF. <i>Clin Cancer Res; 23(18); 5648-56. ©2017 AACR</i>.
Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects (2018)

The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits.
Adaptive blind signal processing-neural network approaches (1998)

Learning algorithms and underlying basic mathematical ideas are presented for the problem of adaptive blind signal processing, especially instantaneous blind separation and multichannel blind deconvolution/equalization of independent source signals. We discuss developments of adaptive learning algorithms based on the natural gradient approach and their properties concerning convergence, stability, and efficiency. Several promising schemas are proposed and reviewed in the paper. Emphasis is given to neural networks or adaptive filtering models and associated online adaptive nonlinear learning algorithms. Computer simulations illustrate the performances of the developed algorithms. Some results presented in this paper are new and are being published for the first time.
<title>Multithresholding for document image segmentation</title> (1995)

Document images contain information in several dominant intensity levels. Detecting these dominant levels helps segmenting the regions in the image that need to be processed differently, if subsequently the image was to be recognized or printed. In this paper we propose a multithresholding algorithm to segment different dominant intensity levels in a document image based on intensity histogram and intensity transition histograms of the image. The method involves determining the number of dominant intensity levels in the image and computing the necessary number of thresholds that facilitate the segmentation.
Performance of MPI broadcast algorithms (2008)

As cluster computing has gotten cheaper and more powerful, ever larger clusters are being built and ever larger problems are being tackled. Many, if not most, of these problems require the broadcast of data not only at the beginning of the computation but also as it progresses. Given the comparative slowness of communication as opposed to computation, any improvement in communication time can have a significant impact on the time required to complete a computation. This paper looks at the broadcast function of MPI and explores some alternative implementations for the common cluster architecture in which some number of computing nodes are connected via an Ethernet switch. It then compares these implementations to the built-in implementation of broadcast in MPICH2 and suggests a new implementation.
Intramolecular influence of a carboxylic function on platinum blue synthesis. A systematic study of complexes originating from acid amides (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular influence of a carboxylic function on platinum blue synthesis. A systematic study of complexes originating from acid amidesPhilippe Arrizabalaga, Paule Castan, and Jean Pierre LaurentCite this: J. Am. Chem. Soc. 1984, 106, 17, 4814–4818Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/ja00329a028https://doi.org/10.1021/ja00329a028research-articleACS PublicationsRequest reuse permissionsArticle Views482Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhanced Lipid Stability in Whole Wheat Flour by Lipase Inactivation and Antioxidant Retention (2008)

ABSTRACT The purpose of this study was to determine the effectiveness of dry heat, steam, and microwave treatments in decreasing lipase activity, while retaining antioxidant activity, to stabilize whole wheat flour against lipid degradation during storage. Bran was heat‐treated in 230‐g batches using four levels (exposure times) for each of the three treatment methods. Lipase activity and antioxidant activity were quantified for all treatment combinations. None of the treatments significantly decreased antioxidant activity; the levels determined to be optimal, inasmuch as further heating did not significantly decrease lipase activity, were 25 min of dry heat, 60 sec of microwave (1000W), and 60 sec of steam. These treatments effectively decreased lipase activity by 74, 93, and 96%, respectively. Optimum treatments were evaluated for acceptance using a consumer sensory panel during a 12‐month storage period. No significant differences in acceptance were found between the control and any of the samples either at baseline or after storage. This suggests that whole wheat flour can be stabilized against lipolysis by utilizing the treatments described in this study without decreasing antioxidant activity, and that manufacturers may utilize these treatments without risking decreased consumer acceptance.
Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir (1988)

The vir locus of Bordetella pertussis apparently encodes a trans-acting positive regulator that is required for the coordinate expression of genes associated with virulence: pertussis toxin, filamentous hemagglutinin (FHA), hemolysin, and adenylate cyclase toxin. DNA clones of vir and of genes required for the synthesis of some of the factors under vir control were obtained with DNA probes from the chromosomal DNA surrounding sites of Tn5 insertion mutations that inactivated those genes. Two vir clones were found which also contained genes required for the proper expression of FHA in B. pertussis. The plasmids which contained both the fha and vir genes expressed immunologically reactive FHA in Escherichia coli, as detected by colony blots, whereas plasmids which contained only fha or vir were negative in this assay. The regulation of FHA production in E. coli, as in B. pertussis, was temperature dependent and inhibited by high concentrations of either magnesium ions or nicotinic acid, indicating that the sequences cloned in E. coli contained the information required to preserve the physiological responses seen in B. pertussis. Further characterization of the vir-fha clones by Tn5 mutagenesis in E. coli and by the return of cloned sequences to B. pertussis in trans and to the B. pertussis chromosome led to the localization of the vir locus, the structural gene for FHA, and genes that are possibly required for the synthesis and export of FHA.
Carcinoma of the pancreatic head area. Diagnostic imaging: ultrasound. (1996)

At present ultrasound (US) is performed as first choice exam in the diagnostic approach to the patient with suspected carcinoma of the pancreatic head area. The role of US is limited because of the difficult assessment of the infiltration of peripancreatic fat, of hollow viscera and of adjacent vascular structures. Lymph node invasion is better shown by CT than by US. A significant improvement in the diagnostic accuracy may be possible with the clinical application of the new US procedures as color-Doppler US, endoscopic US and laparoscopic US.
Case study: visualizing ocean currents with color and dithering (2001)

This case study presents several related approaches to visualizing flow information from large vector volumes generated by ocean circulation modeling. Flow vectors are mapped to colored pixels to enable global views of dense three-dimensional vector fields. Each of the approaches starts by classifying vector direction into a small number of colors. One approach then uses scaled linear interpolation to blend between adjacent directional colors. Two other approaches use half-toning and dithering methods to rapidly display flow information. By using opponent colors for our directional encoding, we can blend colors, either through linear interpolation or the user's visual system, into intermediate colors without expressly calculating them by a conversion to polar coordinates.
Reinforcement Learning with a Corrupted Reward Channel (2017)

No real-world reward function is perfect. Sensory errors and software bugs may result in agents getting higher (or lower) rewards than they should. For example, a reinforcement learning agent may prefer states where a sensory error gives it the maximum reward, but where the true reward is actually small. We formalise this problem as a generalised Markov Decision Problem called Corrupt Reward MDP. Traditional RL methods fare poorly in CRMDPs, even under strong simplifying assumptions and when trying to compensate for the possibly corrupt rewards. Two ways around the problem are investigated. First, by giving the agent richer data, such as in inverse reinforcement learning and semi-supervised reinforcement learning, reward corruption stemming from systematic sensory errors may sometimes be completely managed. Second, by using randomisation to blunt the agent's optimisation, reward corruption can be partially managed under some assumptions.
Enhanced Fluorescence Intermittency of CdSe-ZnS Quantum-Dot Clusters (2006)

Fluorescence intermittency, or blinking, of individual close-packed clusters containing two or more CdSe-ZnS quantum dots (QDs) was investigated. The QD clusters exhibited rapid, intense blinking that was distinct from that of isolated QDs blinking independently. This enhanced blinking is suggested to occur when the QDs in the cluster become electronically coupled. The nature of this coupling is not known, though electrons trapped from QDs when they blink off may play a role by altering the electronic environment of neighboring QDs and enhancing their fluorescence properties.