gebhart/patrepeval huggingface dataset:
<title>High-efficiency microwave and millimeter-wave electro-optical modulation with whispering-gallery resonators</title> (2002)

We present electro-optic modulator based on toroidal lithium niobate cavity with whispering-gallery modes, superimposed with stripline resonator. With microwave resonance (quality-factor Q ~ 10<SUP>2</SUP>) tuned to the free spectral range of optical modes (Q ~ 5x10<SUP>6</SUP>), controlling power ú10mW is achieved in 9GHz prototype, and preliminary results with 33GHz prototype are obtained. Further efficiency improvement will enable various applications in microwave photonics.
Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody (2021)

A single domain antibody (clone CC3) previously found to neutralize a vaccine strain of the chikungunya virus (PRNT<sub>50</sub> = 2. 5 ng/mL) was found to be broadly neutralizing. Clone CC3 is not only able to neutralize a wild-type (WT) strain of chikungunya virus (CHIKV), but also neutralizes WT strains of Mayaro virus (MAYV) and Ross River virus (RRV); both arthralgic, Old World alphaviruses. Interestingly, CC3 also demonstrated a degree of neutralizing activity against the New World alphavirus, Venezuelan equine encephalitis virus (VEEV); albeit both the vaccine strain, TC-83, and the parental, WT Trinidad donkey strain had PRNT<sub>50</sub> values ~1,000-fold higher than that of CHIKV. However, no neutralization activity was observed with Western equine encephalitis virus (WEEV). Ten CC3 variants designed to possess a range of isoelectric points, both higher and lower, were constructed. This approach successfully identified several lower pI mutants which possessed improved thermal stabilities by as much as 10°C over the original CC3 (T<sub>m</sub> = 62°C), and excellent refolding abilities while maintaining their capacity to bind and neutralize CHIKV.
Multi-Part Modeling and Segmentation of Left Atrium in C-Arm CT for Image-Guided Ablation of Atrial Fibrillation (2013)

As a minimally invasive surgery to treat atrial fibrillation (AF), catheter based ablation uses high radio-frequency energy to eliminate potential sources of abnormal electrical events, especially around the ostia of pulmonary veins (PV). Fusing a patient-specific left atrium (LA) model (including LA chamber, appendage, and PVs) with electro-anatomical maps or overlaying the model onto 2-D real-time fluoroscopic images provides valuable visual guidance during the intervention. In this work, we present a fully automatic LA segmentation system on nongated C-arm computed tomography (C-arm CT) data, where thin boundaries between the LA and surrounding tissues are often blurred due to the cardiac motion artifacts. To avoid segmentation leakage, the shape prior should be exploited to guide the segmentation. A single holistic shape model is often not accurate enough to represent the whole LA shape population under anatomical variations, e.g., the left common PVs vs. separate left PVs. Instead, a part based LA model is proposed, which includes the chamber, appendage, four major PVs, and right middle PVs. Each part is a much simpler anatomical structure compared to the holistic one and can be segmented using a model-based approach (except the right middle PVs). After segmenting the LA parts, the gaps and overlaps among the parts are resolved and segmentation of the ostia region is further refined. As a common anatomical variation, some patients may contain extra right middle PVs, which are segmented using a graph cuts algorithm under the constraints from the already extracted major right PVs. Our approach is computationally efficient, taking about 2.6 s to process a volume with 256 × 256 × 245 voxels. Experiments on 687 C-arm CT datasets demonstrate its robustness and state-of-the-art segmentation accuracy.
Automated polymerase chain reaction for papillomavirus screening of cervicovaginal lavages: Comparison with dot‐blot hybridization in a sexually transmitted diseases clinic population (1990)

The aim of the present study was to compare the recently developed polymerase chain reaction (PCR) technique with conventional dot-blot DNA hybridization for human papillomavirus (HPV) detection. Cells were collected by cervicovaginal lavage from a study group of 109 women attending a sexually transmitted diseases clinic. Using a machine that we developed for alternation of temperature cycles, HPV was detected in 51% of patients by PCR. By dot-blot hybridization, 44% of the patients were positive. Concordance of combined positive and negative results between PCR and dot blot was 69%. The greater sensitivity of PCR may have accounted for 19% of specimens that were PCR positive but dot-blot negative. Unexpectedly, however, 12% of specimens were dot-blot positive but negative by PCR, and several specimens were discordant for type of HPV. Both HPV DNA tests agreed with cytology in 41% of women, and in 33% cytology was negative in the face of positive PCR and dot blot. Concordance of cytology with just PCR was 59%, and only with dot blot was 56%. Cervicography agreed with both HPV DNA tests in 41% of patients, with PCR alone in 55%, and with dot blot alone in 58%. Biopsy results did not reveal a strong correlation between histopathological criteria of HPV infection and detection of HPV DNA by either PCR or dot-blot hybridization. Thus the present study has shown that PCR is a slightly more sensitive indicator of HPV infection than dot-blot hybridization. Agreement of HPV DNA results with conventional screening tests was not strong, an observation consistent with many comparative studies by others. In conclusion, PCR is slightly more sensitive than DNA hybridization for detection of HPV, it can be used in conjunction with specimen collection by gentle lavage of the cervicovaginal epithelium, and the possibility remains that it may prove suitable as a screening test.
Methyl 5(6)-phenylsulfinyl-2-benzimidazolecarbamate, a new, potent anthelmintic (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethyl 5(6)-phenylsulfinyl-2-benzimidazolecarbamate, a new, potent anthelminticEugene A. Averkin, Colin C. Beard, Charles A. Dvorak, John A. Edwards, John H. Fried, John G. Kilian, Richard A. Schiltz, Theodore P. Kistner, J. H. Drudge, and Cite this: J. Med. Chem. 1975, 18, 11, 1164–1166Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/jm00245a029https://doi.org/10.1021/jm00245a029research-articleACS PublicationsRequest reuse permissionsArticle Views215Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Amplifier linearization using a digital predistorter with fast adaptation and low memory requirements (1990)

A method is described for linearizing a power amplifier by predistorting its input. It is particularly well suited to baseband implementation with digital signal processor hardware. In comparison with the most powerful previously published predistorter, it requires four orders of magnitude less memory, reduces convergence time by over three orders of magnitude, eliminates reconvergence time following a channel switch, and eliminates the need for a phase shifter in the feedback path. The predistorter structure is described. Its ability to suppress intermodulation products using only a small table is demonstrated. The effect of predistorter nonidealities (especially limited table size) on the power amplifier's output are analyzed. A fast adaptation algorithm is introduced.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ferroelectric Polarization Induces Electric Double Layer Bistability in Electrolyte-Gated Field-Effect Transistors (2013)

The dense surface charges expressed by a ferroelectric polymeric thin film induce ion displacement within a polyelectrolyte layer and vice versa. This is because the density of dipoles along the surface of the ferroelectric thin film and its polarization switching time matches that of the (Helmholtz) electric double layers formed at the ferroelectric/polyelectrolyte and polyelectrolyte/semiconductor interfaces. This combination of materials allows for introducing hysteresis effects in the capacitance of an electric double layer capacitor. The latter is advantageously used to control the charge accumulation in the semiconductor channel of an organic field-effect transistor. The resulting memory transistors can be written at a gate voltage of around 7 V and read out at a drain voltage as low as 50 mV. The technological implication of this large difference between write and read-out voltages lies in the non-destructive reading of this ferroelectric memory.
Organic Electroluminescent Devices Having Metal Complexes as Cathode Interface Layer (2002)

We developed novel cathode systems, composed of metal complexes, for organic electroluminescent (EL) devices. Alkaline metal complexes, such as mono(8-quinolinolato) lithium (Liq), were used as a cathode interface layer in combination with metallic Al as a cathode material. Similarly, doping the organic electron-transporting layer with alkaline metal complexes was also effective in facilitating the electron injection from the cathode to the organic layer, which results in reducing the drive voltage. In both cases, we assume that alkaline metal ions in the complexes are reduced to free metal by thermally activated Al. Then, the free alkaline metal reacts with electron-transporting materials, forming the radical anions, which facilitate electron injection from the Al cathode.
Audible-frequency methods in assessment of soft tissues (2003)

One of the reasons why MHz-range ultrasonic compressional waves have become a powerful tool for medical diagnostics is that their wavelength is of the order of a millimeter, adequate for imaging an anatomical structural. Other types of acoustic waves that can be generated in soft tissue, such as shear and surface waves, are two–three orders of magnitude slower and, respectively, have a millimeter range wavelength in the audible-frequency range. These waves can be effectively used for imaging and soft tissue characterization in terms of the shear elasticity modulus. This paper is a summary of the studies on applications of the surface and shear waves for diagnostic assessment of soft tissue elasticity and dynamic viscosity performed by the author and his coworkers over three decades. A number of techniques for measuring shear elastic moduli of soft tissue using both wave propagation and the acoustic impedance methods are described. Audible-frequency methods and devices for assessment of skin in dermatological applications, for the detection of breast cancer, for imaging of brain and muscle tissues are analyzed. Various embodiments of the Shear Wave Imaging modality are considered. The reasons for a limited success of the audible-frequency methods despite their great potential in ultrasonic medical imaging and diagnostics are discussed.
Design and Analysis of an X-ray Differential Phase Contrast Imaging System with Grating-less X-ray Source and Detectors (2014)

X-ray differential phase contrast imaging system with a grating-less X-ray source and grating-less detectors are effective for applications with higher X-ray photon energy by decoupling a trade-off the parameters, signal contrast and field-of-view.
50 Gb/s PAM4 Modulated 1065 nm Single-Mode VCSELs Using SMF-28 for Mega-Data Centers (2017)

Optical interconnections for mega-data centers will require longer link lengths than can be readily provided with today's low-cost vertical-cavity surface-emitting laser (VCSEL)based multi-mode technologies. We demonstrate a solution based on 1065-nm single-mode bottom emitting VCSELs to transmit data at 50 Gb/s using four-level pulse-amplitude modulation over a distance of 2 km using a standard single-mode fiber (SMF-28). We address potential concerns regarding the unwanted higher order LP11 mode that can propagate in the SMF-28 fiber. The single-mode VCSELs have oxide apertures in the 6-7 μm range to reduce series resistance and increase output power.
Circuits and architectures for field programmable gate array with configurable supply voltage (2005)

Field programmable gate arrays (FPGAs) with supply voltage (Vdd) programmability have been proposed recently to reduce FPGA power, where the Vdd-level can be customized for FPGA circuit elements and unused circuit elements can be power-gated. In this paper, we first design novel Vdd-programmable and Vdd-gateable interconnect switches with minimal number of configuration SRAM cells. We then evaluate Vdd-programmable FPGA architectures using the new switches. The best architecture in our study uses Vdd-programmable logic blocks and Vdd-gateable interconnects. Compared to the baseline architecture similar to the leading commercial architecture, our best architecture reduces the minimal energy-delay product by 54.39% with 17% more area and 3% more configuration SRAM cells. Our evaluation results also show that LUT size 4 gives the lowest energy consumption, and LUT size 7 leads to the highest performance, both for all evaluated architectures.
Immunochemical Studies of Infectious Mononucleosis (1982)

Abstract. A glycoprotein was isolated from the membrane of the bovine erythrocyte by refluxing the acetone‐ and ethanol‐extracted stroma residue with 75% ethanol. The glycoprotein was purified by phosphocellulose chromatography, ethanol precipitation, lipid‐solvent extraction and DEAE chromatography. The glycoprotein appeared to have two serological determinants, both reactive with antibodies present in the sera of patients with infectious mononucleosis. One of the determinants is similar to the Paul‐Bunnell heterophile antigen found on sheep erythrocytes. It is dependent on carbohydrate, including sialic acid residues. Another specificity, seemingly not shared by sheep erythrocytes to any great extent, is resistance to neuraminidase and to alkaline borohydride treatment and thus it may be located either on the polypeptide portion of the molecule or on an alkali‐stable oligosaccharide. The purified glycoprotein comprises 73% amino acids. Carbohydrate components and their molar ratios were sialic acid (1.0): galactose (1.5): N‐acetylglucosamine (1.1): N‐acetylgalactosamine (0.5): mannose (0.1).
An Improved Method for the Sensitive Detection of Shiga Toxin 2 in Human Serum (2018)

Shiga toxins (Stx) released by Stx-producing <i>E. coli</i> (STEC) are virulence factors that are most closely 3associated with hemolytic uremic syndrome (HUS), a life-threatening complication of intestinal infections by STEC. Stx have to enter into the circulatory system before they are delivered to target organs and cause damage. The presence of Stx in sera could be a risk indicator for HUS development. However, the detection of Stx, particularly Stx2, has been difficult due to the presence of Stx2-binding components in human serum. Here, we report new ELISA-based methods for the detection of Stx1 and Stx2 in human serum and the effect of guanidinium chloride on enhancing the sensitivity for the detection of Stx2. The recovery rate for Stx2 was 62% when Stx2-spiked serum samples were treated with guanidinium chloride at a concentration of 200 mM, in contrast to 17% without guanidinium chloride treatment. The effectiveness of guanidinium chloride treatment for the detection of Stx2 in human serum was validated using sera from STEC-infected patients. Coimmunoprecipitation results indicated a specific physical interaction between Stx2 and the human serum amyloid P component (HuSAP) in human serum samples. Our in vitro study demonstrated that the inhibition from HuSAP alone for the detection of Stx2 was only 20%, much less than 69.6% from human serum at Stx2 level 10 ng/mL, suggesting that there may be other factors that bind Stx2 in human serum. This study indicates that treatment of serum samples with guanidinium chloride may be useful for the early and sensitive detection of Stx2 in sera of STEC-infected patients, so preventive measures can be adopted in a timely manner.
Multicenter evaluation of a second-generation assay for cardiac troponin T (1997)

We report on the evaluation of the second-generation assay for cardiac troponin T (cTnT) on the Enzymun system. This new assay is completely specific for the cardiac isoform of TnT, utilizing two cardiospecific monoclonal antibodies. The assay time is reduced to 45 min. The interassay precision shows a median CV of 5.5%; 20% interassay CV was found between 0.05 and 0.1 microg/L. The cardiosensitivity of the second-generation cTnT assay in patients with ischemic myocardial injury appears equivalent when compared with the first-generation assay. We found no falsely positive results in patients with skeletal muscle damage including multitraumas, surgery patients, and marathon runners who showed highly increased values with the unspecific first-generation assay. In Duchenne disease cTnT was still increased, but to a much lower extent. cTnT remains increased in renal failure, but to a lesser degree than with the first-generation assay. The cause of this increase remains unclear. Although a cross-reactivity of skeletal muscle TnT in the second-generation assay could be excluded by our findings, minor myocardial damage or expression of the cardiac isoform of TnT in regenerating muscles cannot be ruled out in those cases with apparently falsely increased cTnT values. The second-generation cTnT assay is a step forward in the combination of cardiosensitivity and cardiospecificity in biochemical markers for diagnosis of heart disease.
Walkthrough-style multi-finger vein authentication (2017)

We propose a new concept of walkthrough-style finger vein authentication. Adaptive light-sources control enables multi-finger vein capturing in real time. Each finger vein region is precisely detected by utilizing a depth camera. Experiments in a prototype show real-time authentication with high accuracy.
Epitaxial YBa <sub>2</sub> Cu <sub>3</sub> O <sub>7</sub> on Biaxially Textured Nickel (001): An Approach to Superconducting Tapes with High Critical Current Density (1996)

In-plane-aligned, c axis-oriented YBa 2 Cu 3 O 7 (YBCO) films with superconducting critical current densities J c as high as 700,000 amperes per square centimeter at 77 kelvin have been grown on thermomechanically rolled-textured nickel (001) tapes by pulsed-laser deposition. Epitaxial growth of oxide buffer layers directly on biaxially textured nickel, formed by recrystallization of cold-rolled pure nickel, made possible the growth of YBCO films 1.5 micrometers thick with superconducting properties that are comparable to those observed for epitaxial films on single-crystal oxide substrates. This result represents a viable approach for the production of long superconducting tapes for high-current, high-field applications at 77 kelvin.
Multiple Domains of MCIP1 Contribute to Inhibition of Calcineurin Activity (2002)

Calcineurin is a serine/threonine protein phosphatase that plays a critical role in many physiologic processes such as T-cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. Calcineurin-dependent signals are transduced to the nucleus by nuclear factor of activated T-cells (NFAT) transcription factors that undergo nuclear translocation upon dephosphorylation and promote transcriptional activation of target genes. Several endogenous proteins are capable of inhibiting the catalytic activity of calcineurin. Modulatory calcineurin interacting protein 1 (MCIP1) is unique among these proteins on the basis of its pattern of expression and its function in a negative feedback loop to regulate calcineurin activity. Here we show that MCIP1 can be phosphorylated by MAPK and glycogen synthase kinase-3 and that phosphorylated MCIP1 is a substrate for calcineurin. Peptides corresponding to the substrate domain competitively inhibit calcineurin activity in vitro. However, a detailed structure/function analysis of MCIP1 reveals that either of two additional domains of MCIP1 is sufficient for binding to calcineurin in vitro and for inhibition of calcineurin activity in vivo. We conclude that MCIP1 inhibits calcineurin through mechanisms that include, but are not limited to, competition with other substrates such as nuclear factor of activated T-cells.
A classification based framework for concept summarization (2011)

In this paper we propose a novel classification based framework for finding a small number of images summarizing a concept. Our method exploits metadata information available with the images to get the category information using Latent Dirichlet Allocation. We modify the import vector machine formulation based on kernel logistic regression to solve the underlying classification problem. We show that the import vectors provide a good summary satisfying important properties such as coverage, diversity and balance. Furthermore, the framework allows users to specify desired distributions over category, time etc, that a summary should satisfy. Experimental results show that the proposed method performs better than state-of-the-art summarization methods in terms of satisfying important visual and semantic properties.
The diminishing variance algorithm for real‐time reduction of motion artifacts in MRI (1995)

A technique has been developed whereby motion can be detected in real time during the acquisition of data. This enables the implementation of several algorithms to reduce or eliminate motion effects from an image as it is being acquired. One such algorithm previously described is the acceptance/rejection method. This paper deals with another real-time algorithm called the diminishing variance algorithm (DVA). With this method, a complete set of preliminary data is acquired along with information about the relative motion position of each frame of data. After all the preliminary data are acquired, the position information is used to determine which data frames are most corrupted by motion. Frames of data are then reacquired, starting with the most corrupted one. The position information is continually updated in an iterative process; therefore, each subsequent reacquisition is always done on the worst frame of data. The algorithm has been implemented on several different types of sequences. Preliminary in vivo studies indicate that motion artifacts are dramatically reduced.