gebhart/patrepeval huggingface dataset:
Obesity associated with increased brain age from midlife (2016)

Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis of magnetic resonance image-based brain structure on a population-based cohort of healthy adults. Study participants were originally part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) and included 527 individuals aged 20-87 years. Cortical reconstruction techniques were used to generate measures of whole-brain cerebral white-matter volume, cortical thickness, and surface area. Results indicated that cerebral white-matter volume in overweight and obese individuals was associated with a greater degree of atrophy, with maximal effects in middle-age corresponding to an estimated increase of brain age of 10 years. There were no similar body mass index-related changes in cortical parameters. This study suggests that at a population level, obesity may increase the risk of neurodegeneration.
Evaluation of clinical therapeutic effect of traditional Chinese medicine on children's diarrhoea (2001)

To evaluate clinical therapeutic effect of a traditional Chinese medicine on children's diarrhoea. The results indicated that the medicine has a good effect on children's diarrhoea and can be used to treat the disease.
Uw-preservation of cultured human gallbladder epithelial cells: Phenotypic alterations and differential mucin gene expression in the presence of bile (1995)

In orthotopic liver transplantation, extended cold ischemia of the graft may induce cell damage, particularly in biliary epithelium. We have investigated the effects of a cold University of Wisconsin (UW) solution on cultured human gallbladder biliary epithelial cells (GBEC) exposed or not exposed to stagnant bile. In UW solution, morphological alterations of cultured GBEC were not prominent under light microscopy after 16 hours at 4 degrees C, being more striking after 24 to 48 hours. Ultrastructural examination of GBEC showed a condensation of chromatin at the periphery of the nuclei after 16 hours in cold UW solution. Both protein and DNA syntheses were strikingly reduced in these cells. After rewarming in standard Williams' medium at 37 degrees C for 24 hours, cultured GBEC exhibited both normal morphology and function. As in both freshly isolated and routinely cultured GBEC, rewarmed cells expressed various mucin genes, namely MUC1, MUC3, MUC4, MUC5AC, and MUC5B genes, whereas MUC2 mRNAs were barely detectable. A dramatic decline in the steady-state mRNA levels of both MUC3 and MUC5B was found in cultured GBEC versus freshly isolated cells. Addition of bile into UW solution at 4 degrees C had no significant effect on GBEC morphology and DNA and protein syntheses. When bile was added during the rewarming period, both protein and DNA syntheses were strongly reduced. Addition of bile during either storage in UW solution or rewarming period induced increased steady-state MUC2, MUC3 and MUC5AC mRNA levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Learning in realistic networks of spiking neurons and spike‐driven plastic synapses (2005)

We have used simulations to study the learning dynamics of an autonomous, biologically realistic recurrent network of spiking neurons connected via plastic synapses, subjected to a stream of stimulus-delay trials, in which one of a set of stimuli is presented followed by a delay. Long-term plasticity, produced by the neural activity experienced during training, structures the network and endows it with active (working) memory, i.e. enhanced, selective delay activity for every stimulus in the training set. Short-term plasticity produces transient synaptic depression. Each stimulus used in training excites a selective subset of neurons in the network, and stimuli can share neurons (overlapping stimuli). Long-term plasticity dynamics are driven by presynaptic spikes and coincident postsynaptic depolarization; stability is ensured by a refresh mechanism. In the absence of stimulation, the acquired synaptic structure persists for a very long time. The dependence of long-term plasticity dynamics on the characteristics of the stimulus response (average emission rates, time course and synchronization), and on the single-cell emission statistics (coefficient of variation) is studied. The study clarifies the specific roles of short-term synaptic depression, NMDA receptors, stimulus representation overlaps, selective stimulation of inhibition, and spike asynchrony during stimulation. Patterns of network spiking activity before, during and after training reproduce most of the in vivo physiological observations in the literature.
Guanidinium Ylides as a New and Recyclable Source for Aziridines and Their Roles as Chiral Auxiliaries (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTGuanidinium Ylides as a New and Recyclable Source for Aziridines and Their Roles as Chiral AuxiliariesKihito Hada, Toshiko Watanabe, Toshio Isobe, and Tsutomu IshikawaView Author Information Graduate School of Pharmaceutical Sciences Chiba University, 1-33 Yayoi, Inage Chiba 263-8522, Japan Central Research Laboratory Shiratori Pharmaceutical Co. Ltd. 6-11-24 Tsudanuma, Narashino Chiba 275-0016, Japan Cite this: J. Am. Chem. Soc. 2001, 123, 31, 7705–7706Publication Date (Web):July 12, 2001Publication History Received16 March 2001Published online12 July 2001Published inissue 1 August 2001https://pubs.acs.org/doi/10.1021/ja0107024https://doi.org/10.1021/ja0107024rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views964Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aldehydes,Aziridines,Enantioselective synthesis,Guanidine,Stereoselectivity Get e-Alerts
Task Allocation and Path Planning for Collaborative Autonomous Underwater Vehicles Operating through an Underwater Acoustic Network (2013)

Dynamic and unstructured multiple cooperative autonomous underwater vehicle (AUV) missions are highly complex operations, and task allocation and path planning are made significantly more challenging under realistic underwater acoustic communication constraints. This paper presents a solution for the task allocation and path planning for multiple AUVs under marginal acoustic communication conditions: a location-aided task allocation framework (LAAF) algorithm for multitarget task assignment and the grid-based multiobjective optimal programming (GMOOP) mathematical model for finding an optimal vehicle command decision given a set of objectives and constraints. Both the LAAF and GMOOP algorithms are well suited in poor acoustic network condition and dynamic environment. Our research is based on an existing mobile ad hoc network underwater acoustic simulator and blind flooding routing protocol. Simulation results demonstrate that the location-aided auction strategy performs significantly better than the well-accepted auction algorithm developed by Bertsekas in terms of task-allocation time and network bandwidth consumption. We also demonstrate that the GMOOP path-planning technique provides an efficient method for executing multiobjective tasks by cooperative agents with limited communication capabilities. This is in contrast to existing multiobjective action selection methods that are limited to networks where constant, reliable communication is assumed to be available.
[Antibody detection in sera of patients with Schistosomiasis japonica by dot immunogold filtration assay]. (2006)

Serum antibody of schistosomiasis patients was detected by dot immunogold filtration method (DIGFA) in laboratory and field, and F-ELISA was used as control. The results showed that there was no significant difference between these two assays in sensitivity and specificity (P > 0.05), with a high coincidence. DIGFA is easy to operate and may deserve a wide application in the diagnosis of schistosomiasis.
Morris's Garbage Compaction Algorithm Restores Reference Counts (1979)

The two-pass compaction algorithm of F.L. Morris, which follows upon the mark phase in a garbage collector, may be modified to recover reference counts for a hybrid storage management system. By counting the executions of two loops in that algorithm where upward and downward references, respectively, are forwarded to the relocation address of one node, we can initialize a count of active references and then update it but once. The reference count may share space with the mark bit in each node, but it may not share the additional space required in each pointer by Morris's algorithm, space which remains unused outside the garbage collector.
An architectural systems engineering methodology for addressing cyber security (2011)

Abstract This paper discusses important shortcomings of current approaches to systems security engineering. The value and limitations of perimeter security designs are examined. An architectural approach to systems security engineering is introduced as a complementary means for strengthening current approaches. Accordingly, this paper outlines a methodology to identify classes of new reusable system security solutions and an architectural framework based on reuse of the patterns of solutions. It also introduces a new methodology for security metrics intended to stimulate critical solution design tradeoff analyses as part of security design reuse considerations. Examples of problems, potential architectural solutions, and corresponding security metrics are provided. © 2011 Wiley Periodicals, Inc. Syst Eng
An examination of the critical parameters in the constrained junction theory of rubber elasticity (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn examination of the critical parameters in the constrained junction theory of rubber elasticityR. W. Brotzman and J. E. MarkCite this: Macromolecules 1986, 19, 3, 667–675Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/ma00157a032https://doi.org/10.1021/ma00157a032research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Semantic Web Approach to Simplifying Trigger-Action Programming in the IoT (2017)

End-user programming environments for the IoT such as IFTTT rely on a multitude of low-level trigger-action rules that categorize devices and services by technology or brand. EUPont is a Semantic Web ontology that enables users to meet their needs with fewer, higher-level rules that can be adapted to different contextual situations and as-yet-unknown IoT devices and services.
Optical millimeter-wave generation and data transmission for mobile 60-70 GHz-band communications (1996)

For the first time error-free 140 Mbit/s transmissions with optically generated millimeter-waves up to 70 GHz via 12 km fiber or a radio link are reported. Additionally quartz accuracy and sub-Hertz millimeter-wave linewidths are demonstrated.
The influence of microtextured basal lamina analog topography on keratinocyte function and epidermal organization (2004)

The rational design of future bioengineered skin substitutes requires an understanding of the mechanisms by which the three-dimensional microarchitecture of tissue scaffolds modulates keratinocyte function. Microtextured basal lamina analogs were developed to investigate the relationship between the characteristic topography at the dermal-epidermal interface of native skin and keratinocyte function. Microfabrication techniques were used to create master patterns, negative replicates, and collagen membranes with ridges and channels of length scales (e.g., grooves of 50-200 microm in depth and width) similar to the invaginations found in basal lamina at the dermal-epidermal junction of native skin. Keratinocytes were seeded on the surfaces of basal lamina analogs, and histological analyses were performed after 7 days of tissue culture at the air-liquid interface. The keratinocytes formed a differentiated and stratified epidermis that conformed to the features of the microtextured membranes. Morphometric analyses of immunostained skin equivalents suggest that keratinocyte stratification and differentiation increases as channel depth increases and channel width decreases. This trend was most pronounced in channels with the highest depth-to-width ratios (i.e., 200 microm deep, 50 microm wide). It is anticipated that the findings from these studies will elucidate design parameters to enhance the performance of future bioengineered skin substitutes.
Loss of Antinociception Induced by Naloxone Benzoylhydrazone in Nociceptin Receptor-Knockout Mice (1998)

Nociceptin and nociceptin receptor, which show structural similarities to opioid peptides and opioid receptors, respectively, have been recently found to constitute a novel neuromodulatory system. In the brain, however, the physiological role of the modulation via the nociceptin receptor is still unclear. Administered nociceptin produces hyperalgesia and hypolocomotion, whereas the nociceptin receptor-knockout mice show no significant abnormalities in nociceptive thresholds and locomotion. To clarify possible involvement of the nociceptin receptor in the regulation of nociception and locomotion, we made use of the knockout mice and naloxone benzoylhydrazone (NalBzoH) identified originally as a ligand for opioid receptors. Experiments on the cultured cells transfected with the nociceptin receptor cDNA showed that NalBzoH competed with [3H]nociceptin binding and attenuated the nociceptin-induced inhibition of cAMP accumulation. Furthermore, behavioral studies demonstrated that NalBzoH completely inhibited nociceptin-induced hyperalgesia and hypolocomotion. It is therefore likely that NalBzoH can act as a potent antagonist for the nociceptin receptor in vivo. In wild-type mice, NalBzoH induced antinociception but did not affect locomotor activity. In contrast, in the knockout mice, no significant changes in nociception and locomotion were induced by NalBzoH. These results clearly suggest that the nociceptin system takes part in the physiological regulation of nociceptive thresholds but not in the basal modulation of locomotion.
Recent advances in understanding clonal haematopoiesis in aplastic anaemia (2017)

Acquired aplastic anaemia (AA) is an immune-mediated bone marrow failure disorder inextricably linked to clonal haematopoiesis. The majority of AA patients have somatic mutations and/or structural chromosomal abnormalities detected as early as at diagnosis. In contrast to other conditions linked to clonal haematopoiesis, the clonal signature of AA reflects its immune pathophysiology. The most common alterations are clonal expansions of cells lacking glycophosphotidylinositol-anchored proteins, loss of human leucocyte antigen alleles, and mutations in BCOR/BCORL1, ASXL1 and DNMT3A. Here, we present the current knowledge of clonal haematopoiesis in AA as it relates to aging, inherited bone marrow failure, and the grey-zone overlap of AA and myelodysplastic syndrome (MDS). We conclude by discussing the significance of clonal haematopoiesis both for improved diagnosis of AA, as well as for a more precise, personalized approach to prognostication of outcomes and therapy choices.
Genetic determinants of Pseudomonas aeruginosa biofilm establishment (2009)

The establishment of bacterial biofilms on surfaces is a complex process that requires various factors for each consecutive developmental step. Here we report the screening of the comprehensive Harvard Pseudomonas aeruginosa PA14 mutant library for mutants exhibiting an altered biofilm phenotype. We analysed the capability of all mutants to form biofilms at the bottom of a 96-well plate by the use of an automated confocal laser-scanning microscope and found 394 and 285 genetic determinants of reduced and enhanced biofilm production, respectively. Overall, 67 % of the identified mutants were affected within genes encoding hypothetical proteins, indicating that novel developmental pathways are likely to be dissected in the future. Nevertheless, a common theme that emerged from the analysis of the genes with a predicted function is that the establishment of a biofilm requires regulatory components that are involved in survival under microaerophilic growth conditions, arginine metabolism, alkyl-quinolone signalling, pH homeostasis and the DNA repair system.
Rapid Genotyping of Human Papillomavirus by Post-PCR Array-Based Hybridization Techniques (2011)

Kinetic hybridization measurements on a microarray are expected to become a valuable tool for genotyping applications. A method has been developed that enables kinetic hybridization measurements of PCR products on a low-density microarray. This is accomplished by pumping a solution containing PCR products up and down through a porous microarray substrate. After every pumping cycle, the fluorescently labeled PCR products hybridized to capture probes immobilized on the solid surface of the porous microarray substrate are measured. By this method, both binding curves and high-resolution melting curves are obtained instead of the single endpoint hybridization intensities as with commonly used post-PCR array-based hybridization techniques. We used 20 subtypes of the human papillomavirus (HPV) as a model system to test our detection method and blindly analyzed 216 clinical samples. We compared our microarray flowthrough method with a reference method, PCR followed by a reverse line blot (RLB). Real-time hybridization measurements followed by high-resolution melting curves of low concentrations of fluorescently labeled HPV targets on a microarray were successfully carried out without any additional chemical signal amplification. The results of our new method were in good agreement (93%, with a kappa coefficient of κ = 0.88 [95% CI, 0.81 to 0.94]) with the RLB results. All discrepant samples were analyzed by a third method, enzyme immunoassay (EIA). Furthermore, in a number of cases, we were able to identify false-positive samples by making use of the information contained in the kinetic binding and melting curves. This clearly demonstrates the added value of the use of kinetic measurements and high-resolution melting curves, especially for highly homologous targets.
Performance of coded OFDM in a fading environment using high rate low-density parity-check codes (2002)

A bit error analysis of wideband OFDM systems that use high rate (0.67/spl les/R/spl les/0.95) low-density parity-check codes for bit-error protection is presented. Subcarrier modulation methods of BPSK, QPSK, and 16-QAM are implemented on channel models that include shadowed Rician fading and additive white Gaussian noise. The performance of different low-density parity check (LDPC) codes constructed through random and systematic methods is also compared.
Paliperidone: quo vadis? (2007)

Paliperidone, the 9-hydroxy metabolite of risperidone, was approved on 20 December, 2006 by the US Food and Drug Administration for the treatment of schizophrenia. It is also being tested for the treatment of bipolar mania. An on-line query of http://www.pubmed.gov and http://www.clinicaltrials.gov for 'paliperidone' and '9-hydroxy-risperidone' was done, along with an examination of poster presentations at scientific meetings held in 2006. Three 6-week pivotal clinical trials of paliperidone extended-release at fixed doses ranging from 3 to 15 mg administered orally once daily in the treatment of acute schizophrenia demonstrated superior efficacy to placebo. A favourable tolerability profile was also evidenced, except for prolactin elevation and dose-related extra-pyramidal effects. A relapse prevention study provides evidence of superiority of paliperidone over placebo in the maintenance of response. Safety has also been assessed in patients with schizophrenia who are 65 years or older. At present there are no studies available that are powered to directly compare paliperidone to other second-generation antipsychotics, including risperidone. With the impending availability of oral risperidone as a generic medication, cost of oral paliperidone will likely become a significant obstacle to its use.
Automated 2-D cephalometric analysis of X-ray by image registration approach based on least square approximator (2008)

This paper presents a new approach to cephalometric x-ray landmark localization. This approach is based on extracting features from face profile of the lateral skull x-ray. The extracted side profile is then segmented based on knowledge of known local facial structures. Once the face profile is properly segmented, nine perceptually significant landmarks (fiducial points) on the face are registered based on a local maximum curvature computation. These fiducial points are used for point-by-point correspondence to find the transformation coefficients of the control points between two images of a scene. Next, we use the obtained coefficients to find the locations of other landmarks on the target image by mapping the landmarks of the reference image. The algorithm was tested on more than 80 x-ray images to locate 20 landmarks. It was possible to locate the landmarks with accuracy of +/-2mm on more 90% of the landmarks.