gebhart/patrepeval huggingface dataset:
Graph-Based Collaborative Filtering with MLP (2018)

The collaborative filtering (CF) methods are widely used in the recommendation systems. They learn users’ interests and preferences from their historical data and then recommend the items users may like. However, the existing methods usually measure the correlation between users by calculating the coefficient of correlation, which cannot capture any latent features between users. In this paper, we proposed an algorithm based on graph. First, we transform the users’ information into vectors and use SVD method to reduce dimensions and then learn the preferences and interests of all users based on the improved kernel function and map them to the network; finally, we predict the user’s rating for the items through the Multilayer Perceptron (MLP). Compared with existing methods, on one hand, our method can discover some latent features between users by mapping users’ information to the network. On the other hand, we improve the vectors with the ratings information to the MLP method and predict the ratings for items, so we can achieve better effects for recommendation.
Design and synthesis of hybrid nanophotonic-electric network-on-chip architectures (2007)

With increasing application complexity and improvements in CMOS process technology, chip multiprocessors (CMPs) with tens to hundreds of cores on a chip are today becoming a reality. Networks on Chip (NoCs) have emerged as a scalable communication fabric that can support high bandwidth communications in such massively parallel multi-core systems. However, traditional electrical NoC implementations today face significant challenges due to high data transfer latencies, low throughput, and high power dissipation. Silicon nanophotonics on a chip has recently been proposed to overcome limitations of electrical wires. However, designing and optimizing hybrid electro-photonic NoCs requires complex trade-offs and overcoming many design challenges such as thermal tuning, power, and crossing loss overheads. In this thesis, these challenges are addressed by proposing novel hybrid electro-photonic NoC architectures and novel synthesis hybrid NoC frameworks for emerging CMPs. The proposed hybrid electro-photonic NoC architectures are designed for waveguide-based and free-space-based silicon nanophotonics implementations. These architectures are optimized for low-cost, low-power, and low-area overhead, support dynamic reconfiguration to adapt the changing runtime traffic requirements, and have been adapted for both 2D and 3D CMPs. The proposed synthesis frameworks utilize various optimization algorithms such as evolutionary techniques, linear programming, and custom heuristics to perform rapid design space exploration of hybrid electro-photonic (2D and 3D) NoC architectures and trade-off performance and power objectives. Experimental results indicate a strong motivation to consider the proposed architectures for future CMPs, with several orders of magnitude reduction in power consumption and improvements in network throughput and access latencies, compared to traditional electrical 2D and 3D NoC architectures. Compared to other previously proposed hybrid electro-photonic NoC architectures, the proposed architectures are also shown to have lower photonic area overhead, power consumption, and energy-delay product, while maintaining competitive throughput and latency. Unlike any prior work to date, our synthesis frameworks allow further tuning and customization of our proposed architectures to meet designer-specific goals. Together, the architectural and synthesis framework contributions bring the promise of silicon nanophotonics in future massively parallel CMPs closer to reality.
Performance maximization of 3D-stacked cache memory on DVFS-enabled processor (2010)

3D integration increases chip integration density, reduces wire length, wire delay and power consumption on wires. However, increased power density causes increase of temperature, which results in the increase of leakage power consumption and performance degradation. In this paper, we propose a solution to compromise these issues on stacking cache memory on a processor core. Experimental results have shown that the proposed method yields, on the average, 16% performance improvement in terms of instructions per second compared to conventional method. The proposed method also reduces energy consumption by 20% on average, in terms of energy per instruction.
Automated Health Alerts Using In-Home Sensor Data for Embedded Health Assessment (2015)

We present an example of unobtrusive, continuous monitoring in the home for the purpose of assessing early health changes. Sensors embedded in the environment capture behavior and activity patterns. Changes in patterns are detected as potential signs of changing health. We first present results of a preliminary study investigating 22 features extracted from in-home sensor data. A 1-D alert algorithm was then implemented to generate health alerts to clinicians in a senior housing facility. Clinicians analyze each alert and provide a rating on the clinical relevance. These ratings are then used as ground truth for training and testing classifiers. Here, we present the methodology for four classification approaches that fuse multisensor data. Results are shown using embedded sensor data and health alert ratings collected on 21 seniors over nine months. The best results show similar performance for two techniques, where one approach uses only domain knowledge and the second uses supervised learning for training. Finally, we propose a health change detection model based on these results and clinical expertise. The system of in-home sensors and algorithms for automated health alerts provides a method for detecting health problems very early so that early treatment is possible. This method of passive in-home sensing alleviates compliance issues.
Coupling of dual modes in a dielectric waveguide resonator and its application to bandpass filters (1995)

A high-permittivity ceramics (ε r=93)is used to fabricate a rectangular waveguide resonator of square cross section. Two degenerate TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">101</sub> and TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">011</sub> , -like mode of the λ/4 resonator is coupled each other through various perturbations such as a corner cut, a current path on the open end face or a slit on the shorted end face. Excitation of the resonator is also of many kinds, resulting in much option for the BPF configuration. A two-stage BPF is designed using the experimental results on the coupling factor and external Q. It is mounted on a printed circuit board with 3.3GHz of the center frequency and 30MHz of the bandwidth.
Studies of immunity and bacterial invasiveness in mice given a recombinant salmonella vector encoding murine interleukin-6 (1996)

Interleukin-6 (IL-6) was expressed in Salmonella typhimurium in an attempt to increase the mucosal immune response against the bacterium. Murine IL-6 was PCR amplified from cDNA, cloned, sequenced, and found to be functionally active when expressed in S. typhimurium BRD509, the (delta)aroA (delta)aroD vaccine strain. Expression of murine IL-6 did not appear to adversely affect the growth of salmonellae, as the construct was retained in the absence of antibiotic selection and the growth rate was unaffected compared with that of the parent strain in vitro. However, IL-6 expression led to a significant reduction in bacterial invasiveness in vitro and in vivo. Splenocytes and small intestinal lamina propria lymphocytes were isolated from mice orally immunized with BRD509 expressing IL-6 (pKK233-2/IL-6), and the number of antibody-secreting cells was determined by the ELISPOT technique. No differences were observed between mice immunized with BRD509(pKK.233-2/IL-6) and those immunized with BRD509(pKK233-2) with respect to the antibody subclass-specific responses elicited despite the markedly reduced invasiveness of the former. Serum antibody responses were also examined by a kinetic enzyme-linked immunosorbent assay (ELISA), and equivalent levels of antibody response were detected in mice given BRD509(pKK233-2/IL-6) and those given BRD509(pKK233-2). The humoral immune response against bacterial lipopolysaccharides was also examined in transgenic IL-6-deficient mice given oral inocula of BRD509. Equivalent numbers of antibody-secreting cells (ELISPOTs) were observed in the spleens and laminae propriae of both IL-6-deficient (-/-) mice and control (+/+) mice harboring an intact IL-6 gene, whereas small, yet significant differences in the serum immunoglobulin A ELISA titers were observed. These data suggest that the immunoglobulin A response against Salmonella lipopolysaccharides is largely IL-6 independent.
A general synthesis of 5,6-dihydro-.alpha.-pyrones (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA general synthesis of 5,6-dihydro-.alpha.-pyronesR. W. Dugger and Clayton H. HeathcockCite this: J. Org. Chem. 1980, 45, 7, 1181–1185Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/jo01295a002https://doi.org/10.1021/jo01295a002research-articleACS PublicationsRequest reuse permissionsArticle Views427Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biochemistry and molecular biology of tauopathies (2006)

Filamentous tau deposits in neurons or glial cells are the hallmark lesions of neurodegenerative tauopathies, such as Alzheimer's disease, Pick's disease, corticobasal degeneration and progressive supranuclear palsy. Biochemical analyses of Sarkosyl-insoluble tau from brains with tauopathies have revealed that tau deposits in different diseases consisted of different tau isoforms (i.e., all six tau isoforms occur in Alzheimer's disease, four repeat tau isoforms occur in corticobasal degeneration or progressive supranuclear palsy, and three repeat tau isoforms occur in Pick's disease). The discovery of mutations in the tau gene in FTDP-17 has established that abnormalities in tau function or expression are sufficient to cause filamentous aggregation of hyperphosphorylated tau and neurodegeneration similar to that seen in sporadic tauopathies. Because the number of tau inclusions and their regional distribution correlate with clinical symptoms, inhibition of tau aggregation or filament formation in neurons or glial cells may prevent neurodegeneration. We have investigated the effects of 42 compounds belonging to nine different chemical classes on tau filament formation, and found that several phenothiazine and polyphenol compounds, and one porphyrin compound inhibit tau filament formation.
Prevention of PERV Infections in Pig to Human Xenotransplantation by the RNA Interference Silences Gene (2005)

The possibility of preventing the transmission of porcine endogenous retrovirus (PERV) to human cells using short interfering RNAs (siRNA) was investigated. The siRNA for the p30 of PERV gag region was cloned into pSUPER, the polymerase-III H1-RNA gene promoter. A green fluorescence protein (GFP) was also cloned into pSUPER to establish pSXGH. Pig endothelial cells (PEC) were transduced with the LacZ gene by pseudotype infection, and infected with PERV subtype B, resulting in the formation of PEC(LacZ)/PB. The PEC(LacZ)/PB was next transfected with pSXGH-siRNA. The expression of siRNA was provisionally checked by determining the level of expression of GFP. Culture supernatants of infected cells were then inoculated into HEK293 cells. The siRNA clearly destroyed the PERV infectivity of PEC(LacZ)/PB in both transient cell lines and stable clones. Moreover, the decreased levels of mRNA and gag protein were evidenced in the stable clones by real-time PCR and Western blotting, respectively. The final goal of our study was to establish a transgenic pig expressing the siRNA for PERV. The results suggest that siRNA represents a novel approach for controlling PERV infections in clinical xenotransplantation.
Entity matching (2011)

Entity matching that finds records referring to the same entity is an important operation in data cleaning and integration. Existing studies usually use a given similarity function to quantify the similarity of records, and focus on devising index structures and algorithms for efficient entity matching. However it is a big challenge to define "how similar is similar" for real applications, since it is rather hard to automatically select appropriate similarity functions. In this paper we attempt to address this problem. As there are a large number of similarity functions, and even worse thresholds may have infinite values, it is rather expensive to find appropriate similarity functions and thresholds. Fortunately, we have an observation that different similarity functions and thresholds have redundancy, and we have an opportunity to prune inappropriate similarity functions. To this end, we propose effective optimization techniques to eliminate such redundancy, and devise efficient algorithms to find the best similarity functions. The experimental results on both real and synthetic datasets show that our method achieves high accuracy and outperforms the baseline algorithms.
Analysis of the impact of multiple services on dynamic carrier allocations for third generation TDMA systems (2002)

Dynamic resource allocation strategy is proposed to achieve high capacity and offer multimedia services on TDMA based systems for the next generation cellular system. Using a hybrid channel allocation scheme fully compatible with packet reservation multiple access (PRMA++), this paper presents an analysis of the impact of data traffic on the capacity of an advanced time division multiple access (ATDMA) system. Based on the results, preliminary dimensioning rules have been derived in order to plan such a TDMA system with the STORMS planning tool.
Light-Directed Reversible Assembly of Plasmonic Nanoparticles Using Plasmon-Enhanced Thermophoresis (2016)

Reversible assembly of plasmonic nanoparticles can be used to modulate their structural, electrical, and optical properties. Common and versatile tools in nanoparticle manipulation and assembly are optical tweezers, but these require tightly focused and high-power (10-100 mW/μm<sup>2</sup>) laser beams with precise optical alignment, which significantly hinders their applications. Here we present light-directed reversible assembly of plasmonic nanoparticles with a power intensity below 0.1 mW/μm<sup>2</sup>. Our experiments and simulations reveal that such a low-power assembly is enabled by thermophoretic migration of nanoparticles due to the plasmon-enhanced photothermal effect and the associated enhanced local electric field over a plasmonic substrate. With software-controlled laser beams, we demonstrate parallel and dynamic manipulation of multiple nanoparticle assemblies. Interestingly, the assemblies formed over plasmonic substrates can be subsequently transported to nonplasmonic substrates. As an example application, we selected surface-enhanced Raman scattering spectroscopy, with tunable sensitivity. The advantages provided by plasmonic assembly of nanoparticles are the following: (1) low-power, reversible nanoparticle assembly, (2) applicability to nanoparticles with arbitrary morphology, and (3) use of simple optics. Our plasmon-enhanced thermophoretic technique will facilitate further development and application of dynamic nanoparticle assemblies, including biomolecular analyses in their native environment and smart drug delivery.
Determination of the Levels of Isoflavonoids in Soybeans and Soy-Derived Foods and Estimation of Isoflavonoids in the Japanese Daily Intake (2000)

The levels of 6 kinds of isoflavonoids found in 11 domestic and imported soybeans, and 12 kinds of soybean-based processed foods in Japan were systematically analyzed, and the Japanese daily intake of isoflavonoids from those foods was estimated. The total isoflavonoids (daidzein, glycitein, and genistein) were analyzed with acid hydrolysis and the intact isoflavonoids (daidzein, glycitein, genistein, daidzin, glycitin, and genistin) were analyzed without hydrolysis. This was followed by cleanup with an ODS cartridge column and determined by liquid chromatography with a diode array detector. The highest content of isoflavonoids was found in kinako (a roasted soybean powder) and the lowest was found in soy sauce. The contents and composition of the isoflavonoids in the 11 soybeans varied by species and country of origin. The level of isoflavonoids found in the processed foods varied by manufacturing method or ingredients. The percentage of aglycone tended to be higher in miso (fermented soybean paste) and soy sauce, which are heated and fermented during the manufacturing process. Japanese daily intake of isoflavonoids from soybeans and soybean-based processed foods was estimated as 27.80 mg per day (daidzein 12.02 mg, glycitein 2.30 mg, and genistein 13.48 mg).
Baseball before we knew it: a search for the roots of the game (2005)

It may be America's game, but no one seems to know how or when baseball really started. Theories abound, myths proliferate, but reliable information has been in short supply-until now, when Baseball before We Knew It brings fresh new evidence of baseball's origins into play. David Block looks into the early history of the game and of the 150-year-old debate about its beginnings. He tackles one stubborn misconception after another, debunking the enduring belief that baseball descended from the English game of rounders and revealing a surprising new explanation for the most notorious myth of all-the Abner Doubleday-Cooperstown story. Block's book takes readers on an exhilarating journey through the centuries in search of clues to the evolution of our modern National Pastime. Among his startling discoveries is a set of long-forgotten baseball rules from the 1700s. Block evaluates the originality and historical significance of the Knickerbocker rules of 1845, revisits European studies on the ancestry of baseball which indicate that the game dates back hundreds, if not thousands of years, and assembles a detailed history of games and pastimes from the Middle Ages onward that contributed to baseball's development. In its thoroughness and reach, and its extensive descriptive bibliography of early baseball sources, this book is a unique and invaluable resource-a comprehensive, reliable, and readable account of baseball before it was America's game.
40-gb/s NRZ and RZ operation of an all-optical AND logic gate based on a passive InGaAsP/InP microring resonator (2006)

The properties of an all-optical AND logic gate based on the four-wave mixing (FWM) effect in an InGaAsP/InP microring resonator side coupled to a bus waveguide are investigated. Using an ultrafast nonlinear process such as FWM, operation at a bit rate of 40 Gb/s is demonstrated for both nonreturn-to-zero (NRZ) and return-to-zero (RZ) modulation formats. The gate operation in terms of microring structural parameters and operating conditions is studied
Using Service Dependency Graph to Analyze and Test Microservices (2018)

Microservice architecture (MSA) is an emerging software architectural style, which differs fundamentally from the monolithic, layered architecture. MSA is based on microservices to provide several advantages, such as autonomy, composability, scalability, and fault-tolerance. However, how to manage complex "call" relationships between microservices is still a big issue that needs to be addressed. In this paper, we propose an approach for assisting the development of MSA-based systems, referred to as GMAT (Graph-based Microservice Analysis and Testing). GMAT can automatically generate "Service Dependency Graph (SDG)" to analyze and visualize the dependency relationships between microservices. Using GMAT, people are able to detect anomalies by analyzing risky service invocation chains in early stage of development, and trace the linkages between services when developing a new version of a target system. Experiments show that GMAT is able to work well for both small-scale and large-scale MSA-based systems.
Mobile Phone Sensor Correlates of Depressive Symptom Severity in Daily-Life Behavior: An Exploratory Study (2015)

Features extracted from mobile phone sensor data, including GPS and phone usage, provided behavioral markers that were strongly related to depressive symptom severity. While these findings must be replicated in a larger study among participants with confirmed clinical symptoms, they suggest that phone sensors offer numerous clinical opportunities, including continuous monitoring of at-risk populations with little patient burden and interventions that can provide just-in-time outreach.
Electrochromic Dye System for Smart Window Applications (2001)

A new coupled bipyridinium-based dye system showing excellent daylight, long term, and cycle stability is presented here. Cells with the coupled system show a stable switching performance for more than 4000 h. Deliberate matching of the counter anion/dye system with the solution allows compensation of the density change, which quenches the color segregation in EC dye systems. The figure shows an EC cell containing the electrochromic dye system PpVBPhP as described in this paper.
Messenger RNA Expression of Granulocyte Colony-Stimulating Factor Receptor Isoforms in the Fetus (2003)

Granulocyte colony-stimulating factor (G-CSF) is a growth factor known to support the proliferation, differentiation, and survival of cells of the neutrophil lineage. G-CSF affects these cells after binding to its specific receptor, G-CSF-R, which exists in seven isoforms. While information exists about the distribution of these isoforms in hematopoietic cells and placenta, G-CSF-R isoforms on non-hematopoietic fetal tissues have not been described. Using RT-PCR, we analyzed a variety of human fetal tissues ranging from 6 to 18 weeks gestation. Isoforms I and III were present in all tissues, and the expression of isoform III varied with gestational age. The remaining isoforms were variably expressed in relation to tissue type and gestational age. Thus in the human fetus, G-CSF-R isoform I is the predominant form expressed on non-hematopoietic and hematopoietic tissues.