gebhart/patrepeval huggingface dataset:
Enhanced assessment of DNA/proliferative index by depletion of tumor infiltrating leukocytes prior to monoclonal antibody gated analysis of tumor cell DNA (1994)

Flow cytometry has become an important tool for the analysis of breast tumors, and assessment of S phase fraction and DNA ploidy are potential indicators of tumor aggression. Due to masking or dilution of infrequent tumor cell events, the presence of normal cell types, such as inflammatory cells and fibroblasts, can interfere with accurate DNA analysis of solid tumor samples. MDA-MB-175-VII human breast carcinoma cells, WI-38 human lung fibroblast cells, and peripheral blood leukocytes were mixed, in varying proportions, in order to represent human breast tumor samples. The cells were subsequently treated with CD45 conjugated magnetic microspheres to deplete tumor infiltrating leukocytes, thus enriching for tumor cells. The tumor cell mixtures were then stained with a pan-cytokeratin specific monoclonal antibody or with a monoclonal antibody that reacts with breast epithelial membrane antigen (EMA). When used in combination with monoclonal antibody gating, utilization of this bead-based technology resulted in enhanced precision of DNA analysis.
Combining linear equalization and self-organizing adaptation in dynamic discrete-signal detection (1990)

An adaptive algorithm combining traditional linear equalization techniques and a self-organizing neural learning algorithm is presented. The results show that the performance of the neural equalizer is insensitive to nonlinear learning distortions in dynamic discrete-signal detection. Stabilization of the self-organizing map during undistorted transmission has to be further considered to decrease the absolute mean-square error (MSE) rate of the neural equalizer. The error is due to oscillations in the self-organizing map, mainly caused by the neighborhood learning. The oscillations can be decreased by taking more samples to the map before adapting the <e1 xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</e1> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> values and by decreasing the neighborhood learning parameter β
Computational multiheterodyne spectroscopy (2016)

A computationally enabled approach is used to perform dual-comb spectroscopy without a phase reference.
Biomechanical Comparison of Single-Tunnel—Double-Bundle and Single-Bundle Anterior Cruciate Ligament Reconstructions (2009)

This technique could be an alternative for both single-bundle and double-tunnel-double-bundle anterior cruciate ligament reconstructions to reproduce intact knee kinematics and native anterior cruciate ligament anatomy.
Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer’s Disease: The OmegAD Study (2019)

The effect of ω3-FA supplementation on MMSE and CDR appears to be influenced by baseline tHcy, suggesting that adequate B vitamin status is required to obtain beneficial effects of ω3-FA on cognition.
A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union (2014)

We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody binding. Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the κ and λ light chains. Protein M blocks antibody-antigen union, likely because of its large C-terminal domain extending over the antibody-combining site, blocking entry to large antigens. Similar to the other immunoglobulin-binding proteins such as Protein A, Protein M as well as its orthologs in other Mycoplasma species could become invaluable reagents in the antibody field.
Metamaterials for Novel Terahertz and Millimeter Wave Devices (2007)

We present experimental results of metamaterials operating at terahertz and mm-wave frequencies. Metamaterials consist of a single layer of 200 nm thick gold on a doped or undoped semiconducting substrate. By optical and electronic doping of supporting semiconducting substrates we show external control of planar arrays of metamaterials, characterized with terahertz time domain spectroscopy. Both methods yield meta-material / semiconductor devices which can be utilized as switches or modulators, enabling modulation of THz transmission by 50 percent. Experiments are supported by simulations and results agree well. Because of the universality of metamaterial response over many decades of frequency, these results have implications for other regions of the electromagnetic spectrum and will undoubtedly play a key role in future demonstrations of novel high-performance devices.
Volume holographic image storage and electro-optical readout in a polymer-dispersed liquid-crystal film (1995)

We report storage and electrical switching of holographic image data in an economical polymer-dispersed liquidcrystal material. The hologram is recorded in a fast, single-step process and can be reversibly erased and restored repeatedly by the application of fields of approximately 10-15 V/ microm, with a response time of 22 micros and a relaxation time of 42 micros. Simple (quasi-sinusoidal) holographic transmission gratings also are studied with switching fields of <5 V/ microm and with response and relaxation times of 25 and 44 micros, respectively.
Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures (2020)

Genome editing technologies have transformed our ability to engineer desired genomic changes within living systems. However, detecting precise genomic modifications often requires sophisticated, expensive, and time-consuming experimental approaches. Here, we describe DTECT (Dinucleotide signaTurE CapTure), a rapid and versatile detection method that relies on the capture of targeted dinucleotide signatures resulting from the digestion of genomic DNA amplicons by the type IIS restriction enzyme AcuI. DTECT enables the accurate quantification of marker-free precision genome editing events introduced by CRISPR-dependent homology-directed repair, base editing, or prime editing in various biological systems, such as mammalian cell lines, organoids, and tissues. Furthermore, DTECT allows the identification of oncogenic mutations in cancer mouse models, patient-derived xenografts, and human cancer patient samples. The ease, speed, and cost efficiency by which DTECT identifies genomic signatures should facilitate the generation of marker-free cellular and animal models of human disease and expedite the detection of human pathogenic variants.
AMFS (2014)

We propose a powerful hardware architecture for pixel shading, which enables flexible control of shading rates and automatic shading reuse between triangles in tessellated primitives. The main goal is efficient pixel shading for moderately to finely tessellated geometry, which is not handled well by current GPUs. Our method effectively decouples the cost of pixel shading from the geometric complexity. It thereby enables a wider use of tessellation and fine geometry, even at very limited power budgets. The core idea is to shade over small local grids in parametric patch space, and reuse shading for nearby samples. We also support the decomposition of shaders into multiple parts, which are shaded at different frequencies. Shading rates can be locally and adaptively controlled, in order to direct the computations to visually important areas and to provide performance scaling with a graceful degradation of quality. Another important benefit of shading in patch space is that it allows efficient rendering of distribution effects, which further closes the gap between real-time and offline rendering.
Enhanced yaw stability control to mitigate a vehicle's abnormal yaw motion due to a disturbance (2013)

An enhanced stability control system (200) for a vehicle includes a vehicle status sensor that generates a sensor signal. A driver input sensor that generates an input signal. A controller (214) may disable normal yaw stability control operation and enable body-force-disturbance (BFD) yaw stability control (YSC) operation, which includes at least partially reducing response functions of the normal yaw stability control associated with the input signal, in response to the sensor signal and performing BFD-YSC functions to achieve desired control performance upon the detection of BFD reception. The controller (214) may also or alternatively compare the sensor signal to a threshold and detect an improperly functioning/inoperative vehicle status sensor. The controller (214) disregards information associated with the improperly functioning/inoperative vehicle status sensor, and continues to perform enhanced yaw stability control operations.
Synthesis of diamond by laser-induced chemical vapor deposition (1986)

Diamond has been obtained by ArF excimer laser-induced chemical vapor deposition. The reaction was carried out by use of C2H2 diluted with H2 as a source gas and at the pressure range of 8–75 Torr. The products were characterized by scanning electron microscopy and reflection electron diffraction. Deposits prepared in the temperature range of 40–800 °C, which were measured by the thermocouple attached to the substrate, show several lines of diamond in the reflection electron diffraction photographs. The fact that the laser beam must be concentrated for the diamond formation to occur strongly suggests that the reaction proceeds through a multiple photon process.
Estimating Temperature Reactivity Coefficients by Experimental Procedures Combined with Isothermal Temperature Coefficient Measurements and Dynamic Identification (2006)

A method to evaluate the moderator temperature coefficient (MTC) and the Doppler coefficient through experimental procedures performed during reactor physics tests of PWR power plants is proposed. This method combines isothermal temperature coefficient (ITC) measurement experiments and reactor power transient experiments at low power conditions for dynamic identification. In the dynamic identification, either one of temperature coefficients can be determined in such a way that frequency response characteristics of the reactivity change observed by a digital reactivity meter is reproduced from measured data of neutron count rate and the average coolant temperature. The other unknown coefficient can also be determined by subtracting the coefficient obtained from the dynamic identification from ITC. As the proposed method can directly estimate the Doppler coefficient, the applicability of the conventional core design codes to predict the Doppler coefficient can be verified for new types of fuels such as mixed oxide fuels. The digital simulation study was carried out to show the feasibility of the proposed method. The numerical analysis showed that the MTC and the Doppler coefficient can be estimated accurately and even if there are uncertainties in the parameters of the reactor kinetics model, the accuracies of the estimated values are not seriously impaired.
A Multiple‐Dose Pharmacokinetic Comparison of Naproxen as a Once‐Daily Controlled‐Release Tablet and a Twice‐Daily Conventional Tablet (1987)

The bioequivalence and absorption kinetics of naproxen in a new controlled-release tablet (750 mg or 1,000 mg naproxen) administered once daily were determined relative to an equivalent dose of the conventional naproxen tablet (375 mg or 500 mg naproxen) administered q12h. Naproxen was well absorbed from the controlled-release tablet (about 90%) compared with the conventional tablet. Absorption was dependent on drug release from the tablet matrix. The mean absorption time of naproxen averaged 8.4 hours for the 750-mg controlled-release tablet and 9.2 hours for the 1,000-mg controlled-release tablet. Once-daily administration of the controlled-release tablet resulted in equivalent trough concentrations of naproxen, and steady-state plasma concentrations were maintained within narrower limits than with twice-daily naproxen.
Increasing the imaging capabilities of multimode fibers by exploiting the properties of highly scattering media (2013)

We present a novel design that exploits the focusing properties of scattering media to increase the resolution and the working distance of multimode fiber based imaging devices. Placing a highly scattering medium in front of the distal tip of the multimode fiber enables the formation of smaller sized foci at increased working distances away from the fiber tip. We perform a parametric study of the effect of the working distance and the separation between the fiber and the scattering medium on the focus size. We experimentally demonstrate submicron focused spots as far away as 800μm with 532nm light.
Machine Learning Based Controlled Filtering for Solar PV Variability Reduction with BESS (2021)

The intermittent nature of solar power prevents the large-scale penetration of Photovoltaic (PV) systems in the utility grid as it causes various irregularities such as voltage fluctuations, frequency deviations, and reduced overall output power quality. This paper introduces a novel smoothing control methodology for firming of PV power fluctuations. Battery Energy Storage System (BESS) is coupled with solar panel arrangements and included into the grid for solar power smoothing and to stabilize the above-mentioned irregular behaviors. Additionally, smoothing filters such as Low Pass Filters (LPFs) are integrated along with the BESS for optimal functioning and cost reduction. It has been established that the time constant of a LPF directly impacts the degree of solar PV smoothing. Thus, the proposed methodology utilizes the concepts of machine learning and model predictive control to design a control system that intelligently controls the LPF time constant to efficiently rid the PV profile from fluctuations while operating under practical constraints. A high accuracy prediction system is also developed using neural networks. The proposed controller can flatten solar power variations by utilizing the inputs from our prediction system. In addition to the smoothing performance of our controller, the effect on the battery ramp rate and state of charge is also observed. The proposed firming concept has been described theoretically and simulation results have also been demonstrated.
COMPACT ACCELERATOR CONCEPT FOR PROTON THERAPY (2006)

A new type of compact induction accelerator is under development at the Lawrence Livermore National Laboratory that promises to increase the average accelerating gradient by at least an order of magnitude over that of existing induction machines. The machine is based on the use of high gradient vacuum insulators, advanced dielectric materials and switches and is being developed as a compact flash x-ray radiography source. Research describing an extreme variant of this technology aimed at proton therapy for cancer will be presented.
High-performance flexible asymmetric supercapacitor based on rGO anode and WO <sub>3</sub> /WS <sub>2</sub> core/shell nanowire cathode (2020)

Flexible smart electronics require their energy storage device to be flexible in nature. Developing high-performance flexible energy storage devices require direct integration of electrode active materials on current collectors to satisfy the high electronic/ionic conductivity and long-term durability requirements. Herein, we develop a flexible all-solid-state asymmetric supercapacitor comprised of reduced graphene oxide (rGO) and core/shell tungsten trioxide/tungsten disulfide (WO<sub>3</sub>/WS<sub>2</sub>) nanowire based electrodes. The electrodes synthesized via electrochemical deposition and chemical vapor deposition avoided the necessity to use non-conductive binders and offered excellent cyclic stability. The structural integrity provided by the rGO and WO<sub>3</sub>/WS<sub>2</sub> electrodes facilitated excellent electrochemical stability with capacitance retention of 90% and 100% after 10 000 charge-discharge cycles, respectively. An all-solid-state device provides a voltage window of 1.5 V and more than 70% capacitance retention after 10 000 charge-discharge cycles. Providing 97% capacitance retention upon mechanical bending reveals its potential to be used as an energy storage devices in flexible electronics.
Investigation of the use of uniaxial comb-shaped Galfenol patches for a guided wave-based magnetostrictive phased array sensor (2018)

This paper investigates the use of uniaxial comb-shaped Fe-Ga alloy (Galfenol) patches in the development of a Magnetostrictive Phased Array Sensor (MPAS) for the Guided Wave (GW) damage inspection technique. The MPAS consists of six highly-textured Galfenol patches with a &lt;100&gt; preferred orientation and a Hexagonal Magnetic Circuit Device (HMCD). The Galfenol patches individually aligned to distinct azimuthal directions were permanently attached to a thin aluminum plate specimen. The detachable HMCD encloses a biasing magnet and six sensing coils with unique directional sensing preferences, equivalent to the specific orientation of the discrete Galfenol patches. The preliminary experimental tests validated that the GW sensing performance and directional sensitivity of the Galfenol-based sensor were significantly improved by the magnetic shape anisotropy effect on the fabrication of uniaxial comb fingers to a Galfenol disc patch. We employed a series of uniaxial comb-shaped Galfenol patches to form an MPAS with a hexagonal sensor configuration, uniformly arranged within a diameter of 1”. The Galfenol MPAS was utilized to identify structural damage simulated by loosening joint bolts used to fasten the plate specimen to a frame structure. We compared the damage detection results of the MPAS with those of a PZT Phased Array Sensor (PPAS) collocated to the back surface of the plate. The directional filtering characteristic of the Galfenol MPAS led to acquiring less complicated GW signals than the PPAS using omnidirectional PZT discs. However, due to the detection limit of the standard hexagonal patterned array, the two array sensors apparently identified only the loosened bolts located along one of the preferred orientations of the array configuration. The use of the fixed number of the Galfenol patches for the MPAS construction constrained the capability of sensing point multiplication of the HMCD by altering its rotational orientation, resulting in such damage detection limitation of the MPAS.
New ‘‘diamondlike carbon’’ film deposition process using plasma assisted chemical vapor transport (1986)

We have deposited ‘‘diamondlike carbon’’ films on various substrates using a new plasma assisted chemical vapor transport process in a high rf power density presssure ratio gas discharge. The films reported here exhibit the following properties: (1) high transparency for wavelengths greater than 300 nm; (2) an index of refraction of ∼2 at 850 nm; (3) a hardness between that of quartz and sapphire, increasing with ion energy bombarding the deposition surface; (4) strong adhesion to KBr, sapphire, and Si substrates; (5) high dielectric strength; (6) inertness to highly reactive chemicals.
Specific inhibition of ribonucleotide reductases by peptides corresponding to the C-terminal of their second subunit (1991)

Previous studies have shown that herpes virus ribonucleotide reductase can be inhibited by a synthetic nonapeptide whose sequence is identical to the C-terminal of the small subunit of the enzyme. This peptide is able to interfere with normal subunit association that takes place through the C-terminal of the small subunit. In this report, we illustrate that inhibition of ribonucleotide reductases by peptides corresponding to the C-terminal of subunit R2 is also observed for the enzyme isolated from Escherichia coli, hamster, and human cells. The nonapeptide corresponding to the bacterial C-terminal sequence was found to inhibit E. coli enzyme with an IC50 of 400 microM, while this peptide had no effect on mammalian ribonucleotide reductase. A corresponding synthetic peptide derived from the C-terminal of the small subunit of the human enzyme inhibited both human and hamster ribonucleotide reductases with IC50 values of 160 and 120 microM, respectively. However, this peptide had no inhibitory activity against the bacterial enzyme. Equivalent peptides derived from herpes virus ribonucleotide reductase had no effect on either the bacterial or mammalian enzymes. Thus, subunit association at the C-terminal of the small subunit appears to be a common feature of ribonucleotide reductases. In addition, the inhibitory phenomenon observed with peptides corresponding to the C-terminal appears not only to be universal, but also specific to the primary sequence of the enzyme.
Circulating Plasma MiR-141 Is a Novel Biomarker for Metastatic Colon Cancer and Predicts Poor Prognosis (2011)

We propose that plasma miR-141 may represent a novel biomarker that complements CEA in detecting colon cancer with distant metastasis and that high levels of miR-141 in plasma were associated with poor prognosis.
A Framework for Code Division Multiple Access Wireless Power Transfer (2021)

The availability of energy is one of the major hindrances to unlocking the massive potential of electronic devices. Powering a highly connected network of devices requires multiple access and a wireless power transfer (WPT) solution that is scalable and capable of maintaining a constant power flow regardless of reconfiguration (mutability) and electromagnetic environment (power flow selectivity). In this paper, we present a framework for the implementation of code division multiple access wireless power transfer (CDMA-WPT) for enabling WPT among multiple transmitters and multiple receivers simultaneously. CDMA-WPT maintains power flow selectivity and is easily scalable. An inverter/rectifier topology is presented for the hardware implementation of CDMA-WPT. A design process for practical co-design of high-performance hardware and obtaining a code set is also presented. We demonstrate the hardware implementation of CDMA-WPT using two transmitters and two receivers maintaining a nearly constant 5W operation with nearly 75% dc-dc efficiency, and four transmitters and four receivers maintaining a constant 4W operating with greater than 70% dc-dc efficiency. . This paper is accompanied by a video hardware demonstration in real-time the difference between using orthogonal codes in CDMA versus conventional single-frequency WPT using 4 transmitter-receiver pairs; conventional single-frequency WPT shows up to a 100% deviation from the intended transfer power as opposed to 8.1% for orthogonal codes in CDMA.
The identification of bacteria associated with periodontal disease and dental caries by enzymatic methods (1986)

This brief review describes the potential usefulness of enzymatic reagents for the diagnosis of dental caries and periodontal disease. The cultural tests for salivary S. mutans levels should soon become commercially available in the U.S. and their success may preclude the immediate development of enzymatic diagnostic reagents for this group of organisms. However, in regards to periodontal disease, these enzyme reagents offer great promise, particularly those which measure the trypsin‐like activity of plaque. The BANA hydrolytic activity of plaque, while not due exclusively to the spirochetes, nevertheless seems to reflect the spirochetal load of the plaque. Of even greater interest is the possibility that this and other enzymes can also be measured in the saliva. This would lend itself to routine screening for these enzymes in the saliva.