gebhart/patrepeval huggingface dataset:
Generalized Mutual Interdependence Analysis of Noisy Channels (2012)

The main motivation for our present work is to reliably perform voice (or signal) detection for a source of interest from a single microphone recording. We rely on the assumption that the input signal contains invariant information about the channel, or transfer function from each source to the microphone, which could be reliably exploited for signal detection and classification. In this chapter we employ a nonconventional method called generalized mutual interdependence analysis (GMIA) that proposes a model for the computation of this hidden invariant information present across multiple measurements. Such information turns out to be a good characteristic feature of a signal source, transformation, or composition that fits the model. This chapter introduces a unitary and succinct description of the underlying model of GMIA, and the formulation and solution of the corresponding optimization problem. We apply GMIA for feature extraction in the problem of own-voice activity detection, which aims at classification of a near-field channel based on access to prior information about GMIA features of the channel. It is extremely challenging to recognize the presence of voice in noisy scenarios with interference from music, car noise, or street noise. We compare GMIA with MFCC and cepstral-mean features. For example, GMIA performs with equal error rates below 10 % for music interference of SNRs down to − 20 dB.
Four-Band Linear-Phase Orthogonal Spatial Filter Bank for Subband Video Coding (2006)

In wavelet-based scalable video coding schemes, temporal interframe redundancy is exploited by applying a temporal wavelet transform along the motion trajectories. A spatial decomposition of the temporal subbands is further performed to take advantage of the spatial redundancy of the filtered frames. However, most of the t+2D video codecs do not take into account the very different spatial characteristics of the temporal subband frames and use indifferently the same spatial 9/7 biorthogonal transform to decompose them. In this paper, we present a spatial transform based on a four-band filter bank, whose frequency selectivity properties are shown to be more suited to represent detail frames. We give the analytical form of a linear-phase, orthogonal and regular four-band filter bank and we show by experimental results conducted on video sequences that significant improvements in terms of PSNR can be obtained using the proposed filter bank to decompose the detail frames.
Local SAR in parallel transmission pulse design (2011)

The management of local and global power deposition in human subjects (specific absorption rate, SAR) is a fundamental constraint to the application of parallel transmission (pTx) systems. Even though the pTx and single channel have to meet the same SAR requirements, the complex behavior of the spatial distribution of local SAR for transmission arrays poses problems that are not encountered in conventional single-channel systems and places additional requirements on pTx radio frequency pulse design. We propose a pTx pulse design method which builds on recent work to capture the spatial distribution of local SAR in numerical tissue models in a compressed parameterization in order to incorporate local SAR constraints within computation times that accommodate pTx pulse design during an in vivo magnetic resonance imaging scan. Additionally, the algorithm yields a protocol-specific ultimate peak in local SAR, which is shown to bound the achievable peak local SAR for a given excitation profile fidelity. The performance of the approach was demonstrated using a numerical human head model and a 7 Tesla eight-channel transmit array. The method reduced peak local 10 g SAR by 14-66% for slice-selective pTx excitations and 2D selective pTx excitations compared to a pTx pulse design constrained only by global SAR. The primary tradeoff incurred for reducing peak local SAR was an increase in global SAR, up to 34% for the evaluated examples, which is favorable in cases where local SAR constraints dominate the pulse applications.
Differential-Phase-Shift Quantum Key Distribution (2006)

A novel type of quantum key distribution (QKD) protocol called differential-phase-shift (DPS) QKD is described. It utilizes a weak coherent pulse train instead of individual photons as in conventional QKD
Sequential Entropy Coding of Quantization Indices with Update Recursion on Probability (2011)

In lossy coding, quantization indices generally contain dependencies. Encoding of quantization indices requires an entropy coding method that exploits these dependencies efficiently. In this articl ...
Generating SQL/XML query and update statements (2009)

The XML support in relational databases and the SQL/XML language are still relatively new as compared to purely relational databases and traditional SQL. Today, most database users have a strong relational and SQL background. SQL/XML enables users to perform queries and updates across XML and relational data, but many struggle with writing SQL/XML statements or XQuery update expressions. One reason is the novelty of SQL/XML and of the XQuery expressions that must be included. Another problem is that the tree structure of the XML data may be unknown or difficult to understand for the user. Evolving XML Schemas as well as hybrid XML/relational schemas make it even harder to write SQL/XML statements. Also, legacy applications use SQL but may require access to XML data without costly code changes. Motivated by these challenges, we developed a method to generate SQL/XML query and update statements automatically. The input is either a GUI or a regular SQL statement that uses logical data item names irrespective of their actual location in relational or XML columns in the database. The output is a SQL/XML statement that queries or updates relational and XML data as needed to carry out the original user statement. This relieves the user and simplifies schema evolution and integration. We have prototyped and tested the proposed method on top of DB2 9.5.
Simulation for Training With the Autosuture <sup>TM</sup> Endo Stitch<sup>TM</sup> Device (2006)

The rapid development and deployment of novel laparoscopic instruments present the surgical educator and trainee with a significant challenge. Several useful instruments have been particularly difficult to teach the novice. We have developed a platform that allows the combination of the actual instrument handle with a virtual re-creation of the instrument tip. We chose the Autosuture Endo Stitch device as the prototypical instrument because it satisfies our subjective experience of "useful, but hard to teach." A software package was developed to support the re-creation of the needle and suture that accompany the device. The apparatus has haptic capabilities and collision detection so that the needle driver is "aware" of suture and instrument contact. The developed virtual environment allows re-creation of the necessary motion to simulate the instrument, the trainee can use the actual instrument handle, and the system can be altered to accommodate other instruments.
Goodpasture Antigen-binding Protein Is a Soluble Exportable Protein That Interacts with Type IV Collagen (2008)

Goodpasture-antigen binding protein (GPBP) is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. Various studies have questioned these findings and proposed that GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. Here we show that cells expressed at least two GPBP isoforms resulting from canonical (77-kDa) and noncanonical (91-kDa) mRNA translation initiation. The 77-kDa polypeptide interacted with type IV collagen and localized as a soluble form in the extracellular compartment. The 91-kDa polypeptide and its derived 120-kDa polypeptide associated with cellular membranes and regulated the extracellular levels of the 77-kDa polypeptide. A short motif containing two phenylalanines in an acidic tract and the 26-residue Ser-rich region were required for efficient 77-kDa polypeptide secretion. Removal of the 26-residue Ser-rich region by alternative exon splicing rendered the protein cytosolic and sensitive to the reduction of sphingomyelin cellular levels. These and previous data implicate GPBPs in a multicompartmental program for protein secretion (i.e. type IV collagen) that includes: 1) phosphorylation and regulation of protein molecular/supramolecular organization and 2) interorganelle ceramide trafficking and regulation of protein cargo transport to the plasma membrane.
Design and fabrication of electrospun polyethersulfone nanofibrous scaffold for high‐flux nanofiltration membranes (2009)

Abstract A novel class of high‐flux and low‐fouling thin‐film nanofibrous composite (TFNC) membranes, containing a thin hydrophilic top‐layer coating, a nanofibrous mid‐layer scaffold and a non‐woven microfibrous support, has been demonstrated for nanofiltration (NF) applications. In this study, the issues related to the design and fabrication of a polyethersulfone (PES) electrospun nanofibrous scaffold for TFNC NF membranes were investigated. These issues included the influence of solvent mixture ratio, solute concentration, additives, relative humidity (RH), and solution flow rate on the morphology of an electrospun PES nanofibrous scaffold, the distribution of fiber diameter, the adhesion between the PES scaffold and a typical poly(ethylene terephthalate) (PET) non‐woven support, as well as the tensile properties of the nanofibrous PES/non‐woven PET composite substrates. Uniform and thin nanofibrous PES scaffolds with strong adhesion to the nanofiber‐PET non‐woven are several of the key parameters to optimize the NF performance of TFNC membranes. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 2288–2300, 2009
Enhanced retention of <i>in vitro</i> functional activity of platelets from recombinant human thrombopoietin‐treated patients following long‐term cryopreservation with a platelet‐preserving solution (ThromboSol) and 2% DMSO (1999)

Chemotherapy-induced thrombocytopenia represents a significant clinical problem in the management of patients with malignancy. Recombinant human thrombopoietin (rhTPO) is a potent stimulator of platelet production in vivo. The ability to cryopreserve rhTPO-derived platelets would enable the use of autologous platelets during the period of thrombocytopenia. ThromboSol is a platelet-stabilizing formulation consisting of second messenger effectors that inhibit specific activation pathways endogenous to platelets. To investigate the effect of ThromboSol cryopreservation, platelets from rhTPO-treated patients (n = 23) and normal donors were treated with ThromboSol and 2% DMSO and cryopreserved for up to 6 months. The platelets were thawed at different intervals and tested for retention of platelet functional activity in vitro. Following a short-term storage (1 week), the cryopreserved platelets from patients treated with rhTPO exhibited significantly higher retention of functional activities including discoid morphology (70% v 57%), extent of shape change (19% v 13%) stirring shape change (15% v 11%) and hypotonic shock response (56% v 25%), as compared to the cryopreserved platelets from controls. Furthermore, there was no further significant loss of functional activity following cryopreservation for up to 6 months. These findings suggest that cryopreservation of platelets from rhTPO-treated donors may provide a useful novel strategy for autologous or allogeneic donation for subsequent transfusions to manage treatment-related thrombocytopenia.
Small Boat HF Radar Cross Sections (1976)

Abstract : The HF radar cross section of three small ocean-going craft were measured in full scale with the SEA ECHO radar. The measurements were made over a wide band of frequencies. Care was taken in the calibration of the system to insure accurate absolute values of cross section. This work was done in support of studies of the use of surface were over-the-horizon radar for ocean range safety surveillance. The results demonstrated a severe fall-off of cross section for these typical craft at frequencies below 4 to 5 MHz.
Correction: Synthesis and electrochemistry of pseudocapacitive multilayer fullerenes and MnO<sub>2</sub>nanocomposites (2014)

Correction for ‘Synthesis and electrochemistry of pseudocapacitive multilayer fullerenes and MnO2 nanocomposites’ by V. K. Azhagan et al., J. Mater. Chem. A, 2014, 2, 2152–2159.
Novel chemico-mechanical approach towards long-term implantable glucose sensing (2009)

The proof of concept of a continuously sensing affinity device based on the glucose-dependent viscosity of a sensitive solution containing dextran and Concanavalin A has been successfully demonstrated. The biosensor incorporates a piezoelectric diaphragm and a flow-resisting microchannel for viscosity detection, and a free-standing Anodic Alumina Oxide (AAO) porous nano-membrane as glucose selective interface. Extensive in vitro glucose measurements between two physiologically relevant glucose concentrations, 2 mM and 9 mM (respectively hypo- and hyperglycemia), were successfully performed during 4 days. To the best of our knowledge, such reversibility and stability of glucose measurement over time had not been reported yet.
Genetics and Control of Tomato Fruit Ripening and Quality Attributes (2011)

Tomato ripening is a highly coordinated developmental process that coincides with seed maturation. Regulated expression of thousands of genes controls fruit softening as well as accumulation of pigments, sugars, acids, and volatile compounds that increase attraction to animals. A combination of molecular tools and ripening-affected mutants has permitted researchers to establish a framework for the control of ripening. Tomato is a climacteric fruit, with an absolute requirement for the phytohormone ethylene to ripen. This dependence upon ethylene has established tomato fruit ripening as a model system for study of regulation of its synthesis and perception. In addition, several important ripening mutants, including rin, nor, and Cnr, have provided novel insights into the control of ripening processes. Here, we describe how ethylene and the transcription factors associated with the ripening process fit together into a network controlling ripening.
Back to the future (2008)

This paper takes a fresh look at the problem of precise verification of heap-manipulating programs using first-order Satisfiability-Modulo-Theories (SMT) solvers. We augment the specification logic of such solvers by introducing the Logic of Interpreted Sets and Bounded Quantification for specifying properties of heap-manipulating programs. Our logic is expressive, closed under weakest preconditions, and efficiently implementable on top of existing SMT solvers. We have created a prototype implementation of our logic over the solvers Simplify and Z3 and used our prototype to verify many programs. Our preliminary experience is encouraging; the completeness and the efficiency of the decisionprocedure is clearly evident in practice and has greatly improved the user experience of the verifier.
Nucleic acid X-ray crystallography via direct selenium derivatization (2011)

X-ray crystallography has proven to be an essential tool for structural studies of bio-macromolecules at the atomic level. There are two major bottle-neck problems in the macromolecular crystal structure determination: phasing and crystallization. Although the selenium derivatization is routinely used for solving novel protein structures through the MAD phasing technique, the phase problem is still a critical issue in nucleic acid crystallography. The background and current progress of using direct selenium-derivatization of nucleic acids (SeNA) to solve the phase problem and to facilitate nucleic acid crystallization for X-ray crystallography are summarized in this tutorial review.
Interferon γ improves the vaccination potential of oncolytic parvovirus H-1PV for the treatment of peritoneal carcinomatosis in pancreatic cancer (2011)

Oncolytic viruses with their capacity to specifically replicate in and kill tumor cells emerged as a novel class of cancer therapeutics. Rat oncolytic parvovirus (H-1PV) was used to treat different types of cancer in preclinical settings and was lately successfully combined with standard gemcitabine chemotherapy in treating pancreatic ductal adenocarcinoma (PDAC) in rats. Our previous work showed that the immune system and particularly the release of interferon-gamma (IFNγ) seem to mediate the anticancer effect of H-1PV in that model. Therefore, we reasoned that the therapeutic properties of H-1PV can be boosted with IFNγ for the treatment of late incurable stages of PDAC like peritoneal carcinomatosis. Rats bearing established orthotopic pancreatic carcinomas with peritoneal metastases were treated with a single intratumoral (i.t.) or intraperitoneal (i.p.) injection of 5 x 10⁸ plaque forming units of H-1PV with or without concomitant IFNγ application. Intratumoral injection proved to be more effective than the intraperitoneal route in controlling the growth of both the primary pancreatic tumors and peritoneal carcinomatosis, accompanied by migration of virus from primary to metastatic deposits. Concomitant i.p. treatment of H-1PV with recIFNγ resulted in improved therapeutic effect yielding an extended animal survival, compared with i.p. treatment with H-1PV alone. IFNγ application enhanced the H-1PV-induced peritoneal macrophage and splenocyte responses against tumor cells while causing a significant reduction in the titers of H1-PV-neutralising antibodies in ascitic fluid. Thus, IFNγ co-application together with H-1PV might be considered as a novel therapeutic option to improve the survival of PDAC patients with peritoneal carcinomatosis.
The chaos router (1991)

We present the chaos router, an asynchronous adaptive router, which under certain circumstances can send messages farther from their destinations. The chaos router greatly simplifies the routing logic by removing the livelock protection of previous schemes. Through an effective use of randomness, whose sources include that due to the adaptively processed load, the natural timing differences of selftimed circuitry and explicitly injected randomization, the chaos router avoids long message routes with high probability. In this paper the router is described, it is argued that the chaos router is deadlock free and probabilistically live-lock and starvation free, and simulation results are presented showing that the chaos router performs well.
Expression of functional diphtheria toxin receptors on highly toxin-sensitive mouse cells that specifically bind radioiodinated toxin. (1992)

Diphtheria toxin (DT), a bacterial protein exotoxin, inactivates mammalian cell elongation factor 2 after toxin internalization by receptor-mediated endocytosis. To isolate the DT receptor, we cotransfected DT-resistant wild-type mouse L-M cells with a cDNA library constructed from RNA of highly toxin-sensitive monkey Vero cells and with a neomycin-resistance gene. Stably transfected G418-resistant L-M colonies were screened for DT sensitivity in a replica plate assay. After screening of 8000 colonies, one DT-sensitive (DTS) colony was isolated. The purified DTS mouse cells are highly toxin-sensitive; they are at least 1000-fold more sensitive than wild-type L-M cells and only approximately 10-fold less sensitive than Vero cells. Incubation of the DTS mouse cells with CRM 197, a nontoxic form of DT that competitively inhibits the binding of native DT to the toxin receptor, protected them from DT-mediated toxicity. More important, these DTS mouse cells express receptors on their cell surface that bind radioiodinated DT in a specific fashion, a property hitherto readily demonstrable only with highly toxin-sensitive cells of monkey origin. Furthermore, HA6DT, a DT fragment comprising the Mr 6000 carboxyl-terminal receptor-binding domain, inhibited the binding of radioiodinated toxin to these DTS mouse cells to the same extent as unlabeled DT. With these DTS mouse cells as a source of monkey cDNA, it should be possible to clone the gene encoding the DT receptor.
Flavonoids: a metabolic network mediating plants adaptation to their real estate (2014)

From an evolutionary perspective, the emergence of the sophisticated chemical scaffolds of flavonoid molecules represents a key step in the colonization of Earth's terrestrial environment by vascular plants nearly 500 million years ago. The subsequent evolution of flavonoids through recruitment and modification of ancestors involved in primary metabolism has allowed vascular plants to cope with pathogen invasion and damaging UV light. The functional properties of flavonoids as a unique combination of different classes of compounds vary significantly depending on the demands of their local real estate. Apart from geographical location, the composition of flavonoids is largely dependent on the plant species, their developmental stage, tissue type, subcellular localization, and key ecological influences of both biotic and abiotic origin. Molecular and metabolic cross-talk between flavonoid and other pathways as a result of the re-direction of intermediate molecules have been well investigated. This metabolic plasticity is a key factor in plant adaptive strength and is of paramount importance for early land plants adaptation to their local ecosystems. In human and animal health the biological and pharmacological activities of flavonoids have been investigated in great depth and have shown a wide range of anti-inflammatory, anti-oxidant, anti-microbial, and anti-cancer properties. In this paper we review the application of advanced gene technologies for targeted reprogramming of the flavonoid pathway in plants to understand its molecular functions and explore opportunities for major improvements in forage plants enhancing animal health and production.
On the Carrier Injection Efficiency and Thermal Property of InGaN/GaN Axial Nanowire Light Emitting Diodes (2014)

We have investigated the impact of surface recombination on the effective carrier injection efficiency and the Joule heating of axial InGaN/GaN nanowire light-emitting diodes (LEDs). The results reveal that the carrier injection efficiency of such devices is extremely low (<;10%), due to the severe carrier loss through nonradiative surface recombination. It is further observed that the thermal resistance of typical nanowire LEDs is comparable with, or lower than that of their planar counterparts, in spite of the reduced thermal conductivity of nanowires. The poor carrier injection efficiency, however, leads to significantly elevated junction temperatures for nanowire LEDs. We have further demonstrated, both theoretically and experimentally, that the carrier injection efficiency can be significantly improved in p-doped nanowires, due to the downward surface band bending, and in InGaN/GaN/AlGaN dot-in-a-wire core-shell nanoscale heterostructures, due to the superior carrier confinement offered by the large bandgap AlGaN shell. This paper offers important insight for the design and epitaxial growth of high-performance nanowire LEDs.
Genetic epistasis of IL23/IL17 pathway genes in Crohnʼs disease (2009)

These data support the investigation of pathways implicated in CD pathogenesis in order to identify further susceptibility genes and also suggest that important gene-gene interaction is present in CD susceptibility.(Inflamm Bowel Dis 2009).