gebhart/patrepeval huggingface dataset:
Dopamine and diltiazem-induced natriuresis in the spontaneously hypertensive rat (1997)

An attenuated natriuretic response to dopamine and D1 agonists in genetic hypertension has been attributed to an uncoupling of the renal D1 dopamine receptor from its G protein-effector protein complex. We have reported that in normotensive Wistar-Kyoto (WKY) rats the natriuresis induced by calcium channel blockers is caused in part by activation of renal D1 dopamine receptors. We tested the interaction between the renal D1 receptor and a calcium channel blocker, diltiazem, infused into a renal artery of anesthetized spontaneously hypertensive rats (SHR) acutely loaded with 5% saline. Diltiazem produced a 50% increase in renal blood flow and nearly tripled absolute and fractional sodium excretion; urine flow rate more than doubled, but glomerular filtration rate did not change. However, the D1 receptor antagonist SKF-83742, which had no effect by itself, did not diminish the response to diltiazem. In a separate group of concurrent experiments, we found that the diltiazem-induced natriuresis was associated with a decrease in Na(+)-K(+)-adenosinetriphosphatase activity in the renal medulla of SHR. In contrast, in WKY rats, no changes were noted in the renal medulla but a decrease in Na(+)-K(+)-adenosinetriphosphatase activity was noted in the renal cortex. Diltiazem had no effect on urinary dopamine excretion in either rat strain. We conclude that diltiazem induces natriuresis differently in SHR and WKY rats; it is independent of D1 receptors in SHR and is in great part mediated by renal hemodynamic, rather than by cortical tubular, effects. These studies support previous findings of a defective renal cortical tubular D1 mechanism in SHR.
Chemistry of heterocyclic compounds series. 110. Cobalt-60 .gamma.-irradiation: homolytic alkylation of methyl nicotinate (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of heterocyclic compounds series. 110. Cobalt-60 .gamma.-irradiation: homolytic alkylation of methyl nicotinateGeorge R. Newkome and Charles R. MarstonCite this: J. Org. Chem. 1985, 50, 21, 4162–4163Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/jo00221a040https://doi.org/10.1021/jo00221a040research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electronic and optical properties of dilute nitrogen quantum dots (2006)

A theoretical study of the electronic and optical properties of the dilute-nitrogen InGaAsN/GaAs quantum dot (QD) structures is presented. The calculations are based on a 10 band k · p band-anti-crossing Hamiltonian incorporating valence, conduction and nitrogen-induced bands. Numerical results for the model system of capped pyramid-shaped QD with [1 0 1] facets on a thin wetting layer are presented. The analysis shows that the influence of nitrogen induces more confined states in the conduction band (CB) than in equivalent nitrogen-free QDs, reducing the energy of the fundamental optical transition. The better confinement in dilute nitrogen QD is because of both the significantly reduced compressive strain, which was one of the major obstacles for a long-wavelength emission from InAs/GaAs QDs, and the BAC effect. These effects, in conjunction with QD size variation, can be of great benefit for the design of devices emitting at longer wavelengths. Furthermore, in contrast to nitrogen-free QDs, dilute nitrogen QDs exhibit reduced dipole matrix element and larger Coulomb interaction energy. The findings are in good agreement with the reported experimental results on similar structures. With appropriate tailoring of the indium and nitrogen concentration, this system could be a potential candidate for a 1.55 µm emission on GaAs substrate.
Granulocyte Colony-Stimulating Factor, Congenital Neutropenia, and Acute Myeloid Leukemia (1995)

Granulocyte colony-stimulating factor (G-CSF) is one of the latest products of molecular biology to permeate clinical practice. The results with this hematopoietic growth factor have been promising, and in one disease, congenital severe neutropenia, they have been exceptionally interesting. But questions have been raised about the safety of G-CSF in this rare disorder. To understand the clinical effects of G-CSF and the concern about its safety, it is important to know that the growth factor has multiple effects on cells of the granulocytic lineage. It not only stimulates the proliferation and differentiation of myeloid precursors but also enhances the functional . . .
Hydrogen‐Bonding‐Directed Layer‐by‐Layer Assembly of Conjugated Polymers (2004)

Poly(phenylenevinylene) polymers, functionalized with either amine or carboxyl acid groups (see Figure), have been synthesized and assembled using layer‐by‐layer deposition. This hydrogen‐bonding‐driven self‐assembly produces conjugated polymer multilayer films with molecular‐level controlled thickness and architecture. The approach enables the creation of robust thin films via a thermally induced cross‐linking reaction.
Heat treatment of firewood : meeting the phytosanitary requirements (2016)

The movement of firewood within emerald ash borer- (EAB-) infested states and into adjoining states has been a major contributor to the spread of EAB throughout the United States and Canada. In an effort to stop the further spread of EAB from infested areas and to facilitate interstate commerce, USDA Animal and Plant Health Inspection Service (APHIS) has required and are enforcing a heat-treatment process in the firewood industry to heat sterilize firewood before it can be shipped out of infested areas. States and firewood producers are now faced with challenges implementing heat-treatment processes and meeting the heat-treating standard. The purpose of this project was to transfer background knowledge and advanced heat-treating technology to field application through field heat-treatment demonstrations, on-site workshops and web-based training seminars (webinars). We evaluated a series of temperature sensors/probes and data loggers for their applicability in heat-treating process and constructed easy-to-install temperature monitoring systems suitable for field heat-treatment operations of different scales. Successful on-site heat-treatment demonstrations were conducted at four firewood heat-treating facilities. Two training workshops were developed and presented to regulatory field staff and firewood producers. The content of training included certification of treatment facilities, recommended heat-treating strategies, and temperature monitoring and thermal verification.
Decoration of Outer Membrane Vesicles with Multiple Antigens by Using an Autotransporter Approach (2014)

Outer membrane vesicles (OMVs) are spherical nanoparticles that naturally shed from Gram-negative bacteria. They are rich in immunostimulatory proteins and lipopolysaccharide but do not replicate, which increases their safety profile and renders them attractive vaccine vectors. By packaging foreign polypeptides in OMVs, specific immune responses can be raised toward heterologous antigens in the context of an intrinsic adjuvant. Antigens exposed at the vesicle surface have been suggested to elicit protection superior to that from antigens concealed inside OMVs, but hitherto robust methods for targeting heterologous proteins to the OMV surface have been lacking. We have exploited our previously developed hemoglobin protease (Hbp) autotransporter platform for display of heterologous polypeptides at the OMV surface. One, two, or three of the Mycobacterium tuberculosis antigens ESAT6, Ag85B, and Rv2660c were targeted to the surface of Escherichia coli OMVs upon fusion to Hbp. Furthermore, a hypervesiculating ΔtolR ΔtolA derivative of attenuated Salmonella enterica serovar Typhimurium SL3261 was generated, enabling efficient release and purification of OMVs decorated with multiple heterologous antigens, exemplified by the M. tuberculosis antigens and epitopes from Chlamydia trachomatis major outer membrane protein (MOMP). Also, we showed that delivery of Salmonella OMVs displaying Ag85B to antigen-presenting cells in vitro results in processing and presentation of an epitope that is functionally recognized by Ag85B-specific T cell hybridomas. In conclusion, the Hbp platform mediates efficient display of (multiple) heterologous antigens, individually or combined within one molecule, at the surface of OMVs. Detection of antigen-specific immune responses upon vesicle-mediated delivery demonstrated the potential of our system for vaccine development.
Stimulation by d-Glucose of Cyclic Adenosine 3′ : 5′-Monophosphate Accumulation and Insulin Release in Isolated Pancreatic Islets of the Rat (1974)

Abstract In collagenase isolated rat pancreatic islet incubates, d-glucose stimulated the accumulation of cyclic adenosine 3' : 5'-monophosphate (cAMP) as measured both by incorporation of [3H]adenine into cAMP and by assay of the total amount of nucleotide by the protein kinase binding method. l-Glucose failed to stimulate [3H]cAMP accumulation in islets. d-Glucose had no effect on [3H]cAMP accumulation in rat adipocytes. It is therefore concluded that the action of glucose is specific in the islet. Stimulation by d-glucose (5 mg per ml) was detectable after 45 to 135 s. [3H]cAMP accumulated rapidly during the first 10 min of incubation, after which a sustained but lower rate of accumulation was observed up to 120 min. 3-Isobutyl-1-methylxanthine (IBMX), 0.1 mm, markedly potentiated the stimulatory effect of a high glucose concentration, while [3H]cAMP accumulation in the presence of low glucose (0.6 mg per ml) was only slightly raised. Stimulation of cAMP accumulation induced by high glucose in the presence of IBMX was abolished within 3 min when the glucose concentration of the medium was rapidly decreased. Efflux of radioactive cyclic nucleotide was undetectable under basal conditions. In incubates stimulated by high glucose with or without IBMX, elevated contents of [3H]cAMP could be measured from 30 min on, the nucleotide continuing to accumulate in the medium up to 120 min of incubation. Over a range of glucose concentrations (0.6 to 7.0 mg per ml), insulin release after a 60-min incubation was well correlated with medium [3H]cAMP content both in the presence and absence of IBMX. Stimulation of both cAMP accumulation and insulin release were observed with small changes in medium glucose level such as increasing it from 0.9 to 1.2 mg per ml. In the incubation system used here, cAMP accumulation seems to precede the initiation of insulin release. The results presented in this report are compatible with the hypothesis that insulin release induced by glucose may be mediated by cAMP in the β-cell.
Nrf2 Protects Against TWEAK-mediated Skeletal Muscle Wasting (2014)

Skeletal muscle (SM) regeneration after injury is impaired by excessive inflammation. Particularly, the inflammatory cytokine tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a potent inducer of skeletal muscle wasting and fibrosis. In this study we investigated the role of Nrf2, a major regulator of oxidative stress defence, in SM ischemia/reperfusion (I/R) injury and TWEAK induced atrophy. We explored the time-dependent expression of TWEAK after I/R in SM of Nrf2-wildtype (WT) and knockout (KO) mice. Nrf2-KO mice expressed significant higher levels of TWEAK as compared to WT mice. Consequently, Nrf2-KO mice present an insufficient regeneration as compared to Nrf2-WT mice. Moreover, TWEAK stimulation activates Nrf2 in the mouse myoblast cell line C2C12. This Nrf2 activation inhibits TWEAK induced atrophy in C2C12 differentiated myotubes. In summary, we show that Nrf2 protects SM from TWEAK-induced cell death in vitro and that Nrf2-deficient mice therefore have poorer muscle regeneration.
Carnitine biosynthesis in Neurospora crassa: enzymatic conversion of lysine to epsilon-N-trimethyllysine (1976)

The enzymatic conversion of L-lysine, epsilon-N-trimethyl-L-lysine the first series of reactions in the biosynthesis of carnitine in Neurospora crassa, proceeds via sequential methylation of free L-lysine, epsilon-N-methyl-L-lysine, and epsilon -N-dimethyl-L-lysine. The latter two compounds have been shown to be intermediates in the biosynthesis of carnitine by radioisotope dilution and incorporation experiments in growing cultures of N. crassa 33933 (lys-) and 38706 (met-). Methionine but not choline, has been recognized as an effective methyl donor in vivo. Inclusion of choline in the growth medium of strain 33933 does, however, enhance incorporation of the methyl groups of L-[methyl-3H]methionine into carnitine in an apparent "sparing" effect on methionine synthesis. Studies in cell-free extracts of the lysine auxotroph strain 33933 of N. crassa have established that lysine and epsilon-N-methyl and epsilon-N-dimethyllysine are enzymatically methylated, with S-adenosyl-L-methionine as the methyl group donor. The enzyme system appears to have no essential cofactors. Lysine does not induce synthesis of the enzyme system in the wild-type strain 262, whereas both carnitine and epsilon-N-trimethyllysine repress its synthesis in strain 33933.
Insulation Development for the Next European Dipole (2006)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. J. Canfer, D. E. Baynham, R. J. S. Greenhalgh; Insulation Development for the Next European Dipole. AIP Conf. Proc. 31 March 2006; 824 (1): 298–305. https://doi.org/10.1063/1.2192364 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Forming models of plane-and-cylinder faceted bodies from light stripes (1975)

A system is described which uses light stripe input to construct 3-D body models useful for automatic assembly. Special hardware can extract a stripe from a TV picture in about 02 second. Clusters of stripes from single surfaces in the body, and hence the equations of the surfaces themselves, are found by a program which forms hypotheses based on clues in the data and then tries to establish them. The resulting surface equations and the stripe evidence for them are used to produce the body model, which is a union of convex subsets of three-space formed as intersections of (possibly complemented) half-spaces and solid cylinders.
KAJIAN QUANTITY SURVEYOR PADA TAHAP PRE CONTRACT DAN POST CONTRACT STUDY KASUS PROYEK AD-PREMIER OFFICE – JAKARTA (2015)

Proses Pre Contract merupakan suatu proses dimana pihak pemberi tugas dan team Konsultan melakukan persiapan sebelum proyek dilaksanakan dilapangan, sedangkan dalam Post Contract sendiri merupakan suatu proses dimana pemantauan pekerjaan pada saat pelaksanaan dilapangan sampai proses serah terima oleh Penerima Tugas kepada Pemberi tugas. Dengan meneliti tahap-tahap baik Pre Contract maupun Post Contract dapat diketahui pihak-pihak yang bertanggung jawab, masalah-masalah yang sering timbul seperti perbedaan Budget yang terjadi antara Estimasi Biaya dengan nilai yang keluar pada Bill of Quantity (BQ) pada saat Pre Contract dan permasalahannya, lingkup kontrak yang terjadi saat Post Contract yang merupakan permasalahan yang sering timbul pada Consultant Quantity Surveyor sebagai pihak independen antara Pemberi Tugas dengan Penerima Tugas. Studi kasus ini akan melakukan penelitian permasalahn yang terjadi pada kedua tahap tersebut, melakukan perbandingan antara budget saat Estimasi Biaya dengan hasil Bill of Quantity (BQ) pada proyek AD Premier Office – Jakarta. Hasil dari penelitian ini memberikan jawaban bahwa nilai BQ dengan akurasi perhitungan yang sesuai dengan Standart of Remeusurment tidak terlalu jauh nilai perbedaanya dengan tingkat akurasi yang dihasilkan oleh Estimasi awal yang merupakan nilai budget perkiraan yang dihitung oleh Consultant Quantity Surveyor.
Exploiting dynamic timing margins in microprocessors for frequency-over-scaling with instruction-based clock adjustment (2015)

Static timing analysis provides the basis for setting the clock period of a microprocessor core, based on its worst-case critical path. However, depending on the design, this critical path is not always excited and therefore dynamic timing margins exist that can theoretically be exploited for the benefit of better speed or lower power consumption (through voltage scaling). This paper introduces predictive instruction-based dynamic clock adjustment as a technique to trim dynamic timing margins in pipelined microprocessors. To this end, we exploit the different timing requirements for individual instructions during the dynamically varying program execution flow without the need for complex circuit-level measures to detect and correct timing violations. We provide a design flow to extract the dynamic timing information for the design using post-layout dynamic timing analysis and we integrate the results into a custom cycle-accurate simulator. This simulator allows annotation of individual instructions with their impact on timing (in each pipeline stage) and rapidly derives the overall code execution time for complex benchmarks. The design methodology is illustrated at the microarchitecture level, demonstrating the performance and power gains possible on a 6-stage OpenRISC in-order general purpose processor core in a 28nm CMOS technology. We show that employing instruction-dependent dynamic clock adjustment leads on average to an increase in operating speed by 38% or to a reduction in power consumption by 24%, compared to traditional synchronous clocking, which at all times has to respect the worst-case timing identified through static timing analysis.
Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution (1996)

Diaspirin cross-linked hemoglobin solution doses of 25, 50, and 100 mg/kg are well tolerated, without evidence of organ dysfunction or toxicity. Diaspirin cross-linked hemoglobin solution's pressor effect is without evidence of decreased peripheral perfusion. Further investigations of its use in certain patient populations are warranted.
<sup>64</sup>CuCl<sub>2</sub> PET/CT in Prostate Cancer Relapse (2017)

Our objective was to evaluate the biodistribution, kinetics, and radiation dosimetry of <sup>64</sup>CuCl<sub>2</sub> in humans and to assess the ability of <sup>64</sup>CuCl<sub>2</sub> PET/CT to detect prostate cancer (PCa) recurrence in patients with biochemical relapse. <b>Methods:</b> We prospectively evaluated 50 PCa patients with biochemical relapse after surgery or external-beam radiation therapy. All patients underwent <sup>64</sup>CuCl<sub>2</sub> PET/CT, <sup>18</sup>F-choline PET/CT, and multiparametric MRI within 15 d of each other. Experienced readers interpreted the images, and the detection rate (DR) of each imaging modality was calculated. Histopathology, when available; clinical or laboratory response; and multidisciplinary follow-up were used to confirm the site of disease. In parallel, biodistribution, kinetics of the lesions, and radiation dosimetry of <sup>64</sup>CuCl<sub>2</sub> were evaluated. <b>Results:</b> From a dosimetric point of view, an administered dose of 200 MBq for <sup>64</sup>CuCl<sub>2</sub> translated into a 5.7-mSv effective dose. Unlike <sup>18</sup>F-choline, <sup>64</sup>CuCl<sub>2</sub> was not excreted or accumulated in the urinary tract, thus allowing thorough pelvic exploration. The maximum <sup>64</sup>CuCl<sub>2</sub> uptake at the sites of PCa relapse was observed 1 h after tracer injection. In our cohort, <sup>64</sup>CuCl<sub>2</sub> PET/CT proved positive in 41 of 50 patients, with an overall DR of 82%. The DRs of <sup>18</sup>F-choline PET/CT and multiparametric MRI were 56% and 74%, respectively. The difference between the DRs of <sup>64</sup>CuCl<sub>2</sub> PET/CT and <sup>18</sup>F-choline PET/CT was statistically significant (<i>P</i> < 0.001). Interestingly, on considering prostate-specific antigen (PSA) value, <sup>64</sup>CuCl<sub>2</sub> PET/CT had a higher DR than <sup>18</sup>F-choline PET/CT in patients with a PSA of less than 1 ng/mL. <b>Conclusion:</b> The biodistribution of <sup>64</sup>CuCl<sub>2</sub> is more suitable than that of <sup>18</sup>F-choline for exploring the pelvis and prostatic bed. The <sup>64</sup>CuCl<sub>2</sub> effective dose is like those of other established PET tracers. In patients with biochemical relapse and a low PSA level, <sup>64</sup>CuCl<sub>2</sub> PET/CT shows a significantly higher DR than <sup>18</sup>F-choline PET/CT.
Discovering fine-grained RRC state dynamics and performance impacts in cellular networks (2014)

To conserve power while ensuring good performance on resource-constrained mobile devices, devices transition between different Radio Resource Control (RRC) states in response to network traffic and according to parameters specific to network operators. As RRC states significantly affect application power consumption and performance, it is important to understand how RRC state timers interact with network traffic patterns. In this paper, we show that the impact of RRC states on performance is significantly more complex and diverse than found in previous work. To do so, we introduce an open-source tool that allows the impact of RRC states on network and application performance to be measured in a robust and accurate manner on unmodified user devices, and deploy the tool in 23 countries around the world to test a broad range of cellular network technologies. We detect previously unknown performance problems which increase network latencies by up to several seconds and for LTE, can increase packet losses by an order of magnitude. Through an in-depth cross-layer analysis of several carriers, we examine the lower-layer causes of these problems. We determine that the highly complex state transitions of certain carriers, and in particular poor interactions between state demotions and network traffic, can lead to substantial, unexpected latencies.