gebhart/patrepeval huggingface dataset:
Opioid Induced Hyperalgesia: ClinicalImplications for the Pain Practitioner (2009)

Opioids have been and continue to be used for the treatment of chronic pain. Evidence supports the notion that opioids can be safely administered in patients with chronic pain without the development of addiction or chemical dependency. However, over the past several years, concerns have arisen with respect to administration of opioids for the treatment of chronic pain, particularly non-cancer pain. Many of these involve legal issues with respect to diversion and prescription opioid abuse. Amongst these, opioid induced hyperalgesia (OIH) is becoming more prevalent as the population receiving opioids for chronic pain increases. OIH is a recognized complication of opioid therapy. It is a pro-nocioceptive process which is related to, but different from, tolerance. This focused review will elaborate on the neurobiological mechanisms of OIH as well as summarize the pre-clinical and clinical studies supporting the existence of OIH. In particular, the role of the excitatory neurotransmitter, N-methyl-D-aspartate appears to play a central, but not the only, role in OIH. Other mechanisms of OIH include the role of spinal dynorphins and descending facilitation from the rostral ventromedial medulla. The links between pain, tolerance, and OIH will be discussed with respect to their common neurobiology. Practical considerations for diagnosis and treatment for OIH will be discussed. It is crucial for the pain specialist to differentiate amongst clinically worsening pain, tolerance, and OIH since the treatment of these conditions differ. Tolerance is a necessary condition for OIH but the converse is not necessarily true. Office-based detoxification, reduction of opioid dose, opioid rotation, and the use of specific NMDA receptor antagonists are all viable treatment options for OIH. The role of sublingual buprenorphine appears to be an attractive, simple option for the treatment of OIH and is particularly advantageous for a busy interventional pain practice.
Seal Material and Base Fluid Compatibility: An Overview (2005)

This study compares the seal material compatibility of environmentally adapted base fluids with that of mineral and synthetic base fluids. The seal materials studied were nitrite rubber (NBR), hydrogenated nitrile rubber ( HNBR), and fluorine rubber (FKM) elastomers, which are common in lubricated applications. The base fluids studied were synthetic esters (monoester, polyol ester, complex ester, and diester), a natural ester (i.e., vegetable oil), different types of mineral base oils, polyalphaolefin, and a fluid of very high viscosity index. The base fluids have been studied without additives. The elastomeric properties measured include volume, hardness, tensile strength, and elongation. A small elastomer volume increase was observed for mineral base oils whereas a significant increase was noted for all synthetic esters when tested on NBR and HNBR. The mechanical properties of the elastomers deteriorated in all cases. The amount of deterioration (i.e., in the tensile strength and the elongation) was in general less than 30%.
Theory of acoustic band structure of periodic elastic composites (1994)

We study an elastic composite described by the position-dependent mass density \ensuremath{\rho}(r), the longitudinal speed of sound ${\mathit{c}}_{\mathit{l}}$(r), and the transverse speed of sound ${\mathit{c}}_{\mathit{t}}$(r). For a spatially periodic composite---a ``phononic crystal''---we derive the eigenvalue equation for the frequencies ${\mathrm{\ensuremath{\omega}}}_{\mathit{n}}$(K), where n is the serial number of the band and K is the Bloch wave vector. This is applied to the special case of a binary composite and, further, to the case of infinite cylinders that form a two-dimensional lattice. For this configuration (and no wave-vector component parallel to the cylinders) there are two independent modes of vibration. The elastic displacement u(r) is parallel to the cylinders for one of them---the transverse polarization mode. The other one is a mixed (longitudinal-transverse) polarization mode with u(r) perpendicular to the cylinders. Specifically we consider circular cylinders that form a square lattice. We compute the band structures for the transverse modes of nickel alloy cylinders in an aluminum alloy host, and vice versa. In both situations we find band gaps which extend throughout the Brillouin zone. Within these gaps the transverse vibrations, sound, and phonons are forbidden. We also investigate the dependence of the band gap on the filling fraction and on the material parameters.
Phagocytosis of Erythrocytes Sensitized with Known Amounts of IgGl and IgG3 Anti‐Rh Antibodies (1987)

Phagocytosis was investigated using human peripheral monocytes and erythrocytes sensitized with known amounts of subclass-specific IgG anti-Rh antibodies. The erythrocyte-bound IgG was quantitated by a radiometric antiglobulin test. This evaluation revealed the following: (1) there is a relationship between phagocytosis and the number of erythrocyte-bound IgG molecules; (2) phagocytosis is IgG subclass-dependent, since a similar degree of phagocytosis is observed with fewer IgG3 than IgG1 molecules and also the minimum number of IgG3 molecules for phagocytosis is 150-640, whilst for IgG1 the minimum is 1,230-4,020; (3) the minimum levels of sensitization for phagocytosis should be detectable by the serological antiglobulin test; (4) the phagocytosis assay is no more sensitive than the monocyte rosette assay for the detection of anti-Rh alloantibodies, and (5) phagocytosis of adherent erythrocytes observed by video-enhanced microscopy indicated that erythrocytes may adhere to monocytes for a considerable time before phagocytosis, but that phagocytosis itself was rapid.
OAuth 2.0 Token Introspection (2015)

This specification defines a method for a protected resource to query an OAuth 2.0 authorization server to determine the active state of an OAuth 2.0 token and to determine meta-information about this token. OAuth 2.0 deployments can use this method to convey information about the authorization context of the token from the authorization server to the protected resource.
Low Complexity Pre-Equalization Algorithms for Zero-Padded Block Transmission (2010)

The zero-padded block transmission with linear time-domain pre-equalizer is studied in this paper. A matched filter is exploited to guarantee the stability of the zero-forcing (ZF) and minimum mean square error (MMSE) pre-equalization. Then, in order to compute the pre-equalizers efficiently, an asymptotic decomposition is developed for the positive-definite Hermitian banded Toeplitz matrix. Compared to the direct matrix inverse methods or the Levinson-Durbin algorithm, the computational complexity of the proposed algorithm is significantly decreased and there is no bit error rate degradation when data block length is large.
Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of Lipid Based Formulations - A Review (2012)

More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is rapidly transported into the circulation. SDLFs consist of a mixture of oil and surfactant, in which active drug moiety is incorporated. They get emulsified under conditions of gentle agitation, similar to those which would be encountered in the gastrointestinal tract on mixing with biological fluids. In this review article introduction, advantages and uses of SDLFs to enhance the dissolution and oral bioavailability are overviewed.
Determination of Asphaltenes in Petroleum Crude Oils by Fourier Transform Infrared Spectroscopy (1998)

An analytical method was developed to quantitatively determine the asphaltene content in petroleum crude oils by Fourier transform infrared spectroscopy (FT-IR). Asphaltenes are a solubility class of compounds found in crude oils. They are black to dark brown solids defined by their insolubility in n-alkane solvents. The structure of asphaltene molecules is polynuclear aromatic rings with alkyl side chains and heteroatoms such as nitrogen, oxygen, and sulfur attached. Asphaltenes are known to cause oil well plugging and irreversible catalyst deactivation in refineries. The asphaltene content of 50 crude oils from a wide array of geochemical conditions was determined by the standard n-pentane insolubles method. FT-IR spectra of the 50 crude oils were collected using an attenuated total reflectance cell. A partial least squares model was generated to predict the amount of asphaltenes from 42 of the crude oils. The model was shown to have an R2 value of 0.95 and a standard error of estimate of 0.92 wt %. An independent prediction set of eight crude oils was used to test the validity of the model. The prediction set was shown to have an R2 value of 0.96 and a standard error of prediction of 0.99 wt %. The FT-IR method compares favorably with the current laboratory method in terms of results, is faster, and uses no solvents.
Detecting Digital Forgeries Using Bispectral Analysis (1999)

With the rapid increase in low-cost and sophisticated digital technology the need for techniques to authenticate digital material will become more urgent. In this paper we address the problem of authenticating digital signals assuming no explicit prior knowledge of the original. The basic approach that we take is to assume that in the frequency domain a “natural ” signal has weak higher-order statistical correlations. We then show that “un-natural ” correlations are introduced if this signal is passed through a non-linearity (which would almost surely occur in the creation of a forgery). Techniques from polyspectral analysis are then used to detect the presence of these correlations. We review the basics of polyspectral analysis, show how and why these tools can be used in detecting forgeries and show their effectiveness in analyzing human speech. 1 1
Sympathomodulatory Effects of Antihypertensive Drug Treatment (2016)

Future investigations aimed at answering these questions will be needed in order to improve cardiovascular protection in treated hypertensive patients.
Synthesis and Thermodynamic Studies of Physisorptive Energy Storage Materials (2013)

Physical adsorption of hydrogen or other chemical fuels on the surface of carbonaceous materials offers a promising avenue for energy storage applications. The addition of a well-chosen sorbent material to a compressed gas tank increases the volumetric energy density of the system while still permitting fast refueling, simplicity of design, complete reversibility, high cyclability, and low overall cost of materials. While physical adsorption is most effective at temperatures below ambient, effective storage technologies are possible at room temperature and modestly high pressure. A volumetric Sieverts apparatus was designed, constructed, and commissioned to accurately measure adsorption uptake at high pressures and an appropriate thermodynamic treatment of the experimental data is presented. In Chapter 1, the problem of energy storage is introduced in the context of hydrogen as an ideal alternative fuel for future mobile vehicle applications, and with methane in mind as a near-term solution. The theory of physical adsorption that is relevant to this work is covered in Chapter 2. In-depth studies of two classes of materials are presented in the final chapters. Chapter 3 presents a study of the dissociative “hydrogen spillover” effect in the context of its viability as a practical hydrogen storage solution at room temperature. Chapters 4-5 deal with zeolite-templated carbon, an extremely high surface-area material which shows promise for hydrogen and methane storage applications. Studies of hydrogen adsorption at high pressure (Chapter 4) and anomalous thermodynamic properties of methane adsorption (Chapter 5) on ZTCs are presented. The concluding chapter discusses the impact of and possible future directions for this work.
Two Hydrolase Resistant Analogues of Diadenosine 5',5'''-P,P-Triphosphate for Studies with FHIT, The Human Fragile Histidine Triad Protein (1998)

The design and synthesis of analogues of diadenosine 5',5"'-P1,P3-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein.
Two-axis dry tuned-rotor gyroscopes - Design and technology (1993)

DX,DY = damping coefficient for flexures about XG,YG (N • m • s/deg) d = offset distance (m) as in Fig. 10 db = diameter of bare wire of torquer coil (m) dc = distance between two opposite coils (m) as shown in Fig. 8 dx,dY =(! gx2 = gP associated with opposite pickoffs (m) H = magnitude of angular-momentum vector H of the rotor (kg • m/s) = JZ'US h = coefficient of convective heat transfer for torquer coil (cal/s-m-°C) it = current in torquer coil (A) IxJyJz = moments of inertia of the gimbal about ^,^,Z^(kg.m) JX>JY,JZ = moments of inertia of rotor about XR ,YR,ZR (kg-m) Ki,K2tK3 = rotor's suspension stiffness about axes 1,2,3 (N/m) k\,ki,k^ — gimbal's suspension stiffness about axes 1,2,3 (N/m) KX,KY — torsional stiffness of flexures about XG9YG (N-m/deg) £c = curved length of coil (m) m = direct drift (deg/h) mm = number of off-on cycles for day-to-day drift tests n = number of turns in torquer coil nn = number of data points for a random drift test Pm = mean perimeter of torquer coil (m) q = quadrature drift (deg/h) R = torquer coil resistance (fi) RX,RY = ^f and Y torquer resistances (0) rx,rY = (la) values of random drifts (deg/h) SX,SY = X and Y torquer scale factors (deg/h-A) t — time (s) TD = rotor-to-case drag torque (N-m) TX,TY = moments applied to the rotor about X,Y by the torquers (N • m) Wr = weight of rotor (N) XJ9Yj = X and Y torquer currents in gyro testing (A);
Differential expression of Mart-1 in human uveal melanoma cells (2011)

Uveal melanoma (UM) is one of the most common primary intraocular malignant tumors in adults. Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, has been widely studied as a marker recognized by cytotoxicity T lymphocytes. Mart-1 is considered to play a critical role in the immunotherapy for melanoma. Additionally, as a biomarker, Mart-1 is often used with other tumor-associated antigens for antidiastole in cutaneous melanoma (CM), uveal melanoma (UM) and nevus. In this study, the differential expression of Mart-1 was investigated in four human UM cells (SP6.5, VUP, OCM-1 and OM431) on three levels of analysis: messenger ribonucleic acid (mRNA), protein and, eventually, morphology. The results revealed that SP6.5 cells had high Mart-1 protein expression while VUP cells had almost none. OCM-1 and OM431 cells produced less Mart-1 than SP6.5 cells according to Western blot analysis, although OM431 cells had the highest expression of Mart-1 mRNA according to real-time PCR. The results indicate the potential use of Mart-1 in the development of therapy for UM.
Error concealment in MPEG video streams over ATM networks (2000)

When transmitting compressed video over a data network, one has to deal with how channel errors affect the decoding process. This is particularly a problem with data loss or erasures. In this paper we describe techniques to address this problem in the context of asynchronous transfer mode (ATM) networks. Our techniques can be extended to other types of data networks such as wireless networks. In ATM networks channel errors or congestion cause data to be dropped, which results in the loss of entire macroblocks when MPEG video is transmitted. In order to reconstruct the missing data, the location of these macroblocks must be known. We describe a technique for packing ATM cells with compressed data, whereby the location of missing macroblocks in the encoded video stream can be found. This technique also permits the proper decoding of correctly received macroblocks, and thus prevents the loss of ATM cells from affecting the decoding process. The packing strategy can also be used for wireless or other types of data networks. We also describe spatial and temporal techniques for the recovery of lost macroblocks. In particular, we develop several optimal estimation techniques for the reconstruction of missing macroblocks that contain both spatial and temporal information using a Markov random field model. We further describe a sub-optimal estimation technique that can be implemented in real time.
A low-Z PET detector (1990)

In order to examine the potential of low-Z detector materials for PET (positron emission tomography), a small field imaging system using plastic detectors has been designed. In this system the site of a photon interaction in the detector is located using light produced by the first Compton electron. This is in contrast to high-Z detectors where multiple interactions occur. The calculated performance of the detector and supporting measurements are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Be well!: a computer-based health care interview for hospital personnel. (1993)

We developed a computer-based health care interview for employees at an urban teaching hospital. The interview is part of the hospital-wide, integrated Center for Clinical Computing (CCC) system at the Beth Israel Hospital in Boston, and is available on 1500 terminals located throughout the hospital. The program emphasizes medical problems and patterns of living for which behavioral change is considered desirable. Conducted in private and with protection of confidentiality, the interview offers information about people and facilities available to help members of the hospital community seek better health. Between May 15, 1990, and May 14, 1992, a total of 1281 people completed the interview, and 84% indicated an interest in one or more of the health-related programs offered by the hospital. That these are difficult times in America was illustrated by the unhappiness reported by 43% of the participants, including 5% who indicated that life sometimes seemed not worth living. We hope they availed themselves of the opportunity offered by the interview to obtain help for their problems, and that other hospitals will do what Beth Israel Hospital is doing to promote well-being among its employees.
Comparison of aqueous humour and serum zinc levels in humans. (1987)

Zinc concentrations in aqueous humour and serum were determined by means of atomic absorption spectrophotometry in 11 patients with cataract. The zinc content of the aqueous humour was found to be considerably lower than the corresponding serum values. From this finding it is suggested that aqueous humour does not serve as a likely route of delivery of zinc to the cornea.
The ANSI T10 object-based storage standard and current implementations (2008)

Object-based storage is the natural evolution of the block storage interface, aimed at efficiently and effectively meeting the performance, reliability, security, and service requirements demanded by current and future applications. The object-based storage interface provides an organizational container, called an object, into which higher-level software (e.g., file systems, databases, and user applications) can store both data and related attributes. In 2004, the ANSI (American National Standards Institute) T10 Standards body ratified an Object-based Storage Device (OSD) command set for SCSI (Small Computer System Interface) storage devices that implements the OSD interface. This paper describes the rationale for OSDs, highlights the ANSI T10 OSD V1.0 interface, and presents three OSD implementations: an OSD from Seagate, an IBM object-based storage prototype (ObjectStone), and the Panasas object-based distributed storage system.
Chondrocyte Implantation for Treatment of Articular Cartilage (2021)

Background: Because articular chondrocyte-based Autologous Chondrocyte Implantations (ACIs) have restrictively restored articular cartilage defects, alternative cell sources as a new therapeutic option for cartilage repair have been introduced.
Purpose: To assess whether implantation of a Costal Chondrocyte–Derived Pellet-Type (CCP) ACI allows safe, functional, and structural restoration of full-thickness cartilage defects in the knee.
Study Design
Case series: Level of evidence, Methods: In this first-in-human study, 7 patients with symptomatic, full-thickness cartilage lesions were enrolled. The chondrocytes isolated from the patients’ costal cartilage were expanded, followed by 3-dimensional pellet culture to prepare the CCP-ACI. Implantation of the pellets was performed via minimal arthrotomy and secured with a fibrin sealant. Clinical scores, including the International Knee Documentation Committee (IKDC) subjective, Lysholm, and Tegner activity scores, were estimated preoperatively and at 1, 2, and 5 years postoperatively. High-resolution magnetic resonance imaging was also performed to evaluate cartilage repair as well as to calculate the MOCART (magnetic resonance observation of cartilage repair tissue) score.
Results: The costal chondrocytes of all patients formed homogeneous-sized pellets, which showed the characteristics of the hyaline cartilaginous tissue with lacunae-occupied chondrocytes surrounded by glycosaminoglycan and type II collagen-rich extracellular matrix. There were no treatment-related serious adverse events during the 5-year follow-up period. Significant improvements were seen in all clinical scores from preoperative baseline to the 5-year follow-up (IKDC subjective score, 34.67 to 75.86; Lysholm score, 34.00 to 85.33; Tegner activity score, 1.17 to 4.67; and MOCART score, 28.33 to 83.33). Two patients had complete defect filling on magnetic resonance imaging evaluation at 1 year. Moreover, at 5 years postoperatively, complete defect filling was observed in 4 patients, and hypertrophy or incomplete defect filling (50%-100%) was observed in 2 patients.
Conclusion: The overall results of this clinical study suggest that CCP-ACI can emerge as a promising therapeutic option for articular cartilage repair with good clinical outcomes and structural regeneration and with stable results at midterm follow-up.
Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms (2016)

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramolecular cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.