gebhart/patrepeval huggingface dataset:
Geology, Geochemistry, and Geochronology of Gabbro from the Haoyaoerhudong Gold Deposit, Northern Margin of the North China Craton (2019)

The Haoyaoerhudong gabbro is a mafic intrusion located in the Haoyaoerhudong gold deposit, which is a giant gold deposit (148 t Au) hosted in Proterozoic strata on the northern margin of the North China Craton. In this paper, we present integrated SHRIMP U–Pb, geochemical and Sr–Nd isotopic data from gabbro of the Haoyaoerhudong gold deposit to reveal the magmatic processes behind its origin. SHRIMP zircon U–Pb dating constrains the timing of crystallization of the Haoyaoerhudong gabbro to 278.8 ± 0.81 Ma. Whole-rock geochemical results indicate that the Haoyaoerhudong gabbro has calc-alkaline features with enrichments of large-ion lithophile elements (LILE) and light rare-earth elements (REE) as well as depletions of high-field strength elements (HFSE). The relatively high (87Sr/86Sr)i (0.7053 to 0.7078) and low εNd(t) (−4.6 to −15.1) values of the gabbro indicate the involvement of crustal materials. Low Ce/Pb ratios (1.35 to 7.38), together with nearly constant La/Sm and Th/Yb ratios and variable Ba/Th and Sr/Nd ratios, suggest that the ancient mantle was modified by slab dehydration fluids. Based on new geochemical data and regional geological investigations, we propose that both the Haoyaoerhudong gold deposit and the Haoyaoerhudong gabbro formed in a post-orogenic extensional setting.
Storage area network applications (2002)

A complimentary approach to SANs known as network attached storage (NAS) relies on IP protocols like Gigabit Ethernet to interconnect application servers with storage appliances. NAS does not segregate storage traffic from other types of IP data, and is typically optimized for smaller data packet transfers, using file protocols rather than block protocols (the maximum data block size for Gigabit Ethernet is 9 kilobytes using jumbo frames). The principle benefit of NAS is its flexibility and ease of installation; storage appliances are designed to "plug and play" on existing local area networks (LANs) with a minimum of effort.
Hyperemic Stenosis Resistance Index for Evaluation of Functional Coronary Lesion Severity (2002)

Single photon emission computed tomography (SPECT) was performed in 151 patients with angina to determine reversible perfusion defects within one-week before cardiac catheterization. Coronary pressure and flow velocity was measured distal to 181 single coronary lesions with a mean diameter stenosis of 56% (range: 32% to 85%). Maximum hyperemia was induced by 15 to 20 microg IC adenosine to determine CFVR, FFR, and the hyperemic stenosis resistance index (h-SRv), defined as the ratio of hyperemic stenosis pressure gradient (mean aorta pressure-mean distal pressure) and hyperemic average peak-flow velocity. Receiver-operating-characteristic curves of CFVR, FFR, and h-SRv were calculated to evaluate the predictive value for presence of reversible perfusion defects on SPECT with the use of the area under curve (AUC). The AUC was significantly higher for h-SRv (0.90+/-0.03) compared with those for CFVR (0.80+/-0.04; P=0.024) and FFR (0.82+/-0.03; P=0.018), respectively. Agreement with SPECT was particularly higher (73%) than for CFVR (49%, P=0.022) or FFR (51%, P=0.037) in the group of lesions showing discordant results between CFVR and FFR CONCLUSION: These results indicate that hyperemic stenosis resistance index is a more powerful predictor of reversible perfusion defects than CFVR or FFR.
Structure and mechanical properties of gelatin/sepiolite nanocomposite foams (2011)

Biocompatible gelatin foams were found to exhibit significantly improved mechanical properties by the additions of sepiolite nanofibres. Gelatin nanocomposite foams containing various contents of sepiolite were prepared by lyophilization. With the presence of 9.1 wt% sepiolite, the Young's modulus and compressive collapse strength of the gelatin foam with a cell size of 159 μm and a porosity of 98% were increased by 288% and 308%, respectively. Such enhancements were attributable to the strong interactions between hydrophilic gelatin and sepiolite as suggested by the results from Fourier transform infrared spectroscopy and differential scanning calorimetry which show substantial shifts in the characteristic absorption peaks and the glass transition temperature, to the reduced cell sizes characterised by scanning electron microscopy, and to the reinforcement effects of sepiolite on the gelatin solid material. The mechanical properties of the low-density closed-cell gelatin/sepiolite nanocomposite foams were well predicted using the Gibson–Ashby model for open cells after normalisation of the Young's modulus of the neat polymer foam.
Activation of c-Jun-NH2-Kinase by UV Irradiation Is Dependent on p21 (1996)

We have demonstrated previously that Jun-NH2-kinase (JNK) activation in vitro is potentiated by association with the p21(ras) protein. To determine if in vivo activation of JNK also depends on p21(ras), we have used M1311 cells that carry the cDNA for the neutralizing antibody to p21(ras), Y13-259, under a dexamethasone-inducible promoter. The ability of UV to activate JNK gradually decreased over a 4-day period of cell growth in dexamethasone. This decrease coincides with weaker transcriptional activation measured via gel shift and chloramphenicol acetyltransferase assays. Peptides corresponding to amino acids 96-110 on p21(ras), which were shown to block Ras-JNK association, inhibited UV-mediated JNK activation in mouse fibroblast 3T3-4A cells as well as in M1311 cells, further supporting the role of p21(ras) in UV-mediated JNK activation. Overall, the present studies provide in vivo confirmation of the role p21(ras) plays in JNK activation by UV irradiation.
Characterization of EL2 distribution on semi-insulating GaAs wafer by optically assisted imperfection profile (1986)

An improved nondestructive characterization technique is developed to measure the relative density distribution of the EL2 level in undoped semi-insulating (SI) GaAs wafers at room temperature. Experimentally, the resistance of a small area of the wafer is measured twice, first with greater than band-gap illumination outside a small masked area and then with a narrow-band optical filter centered at 1074 nm in place of the masked area. The difference of the two measured resistances is shown to be proportional to the density of the EL2 level. By moving the masked area across the wafer while taking resistance measurements, the relative density variation of EL2 can be determined. A theoretical discussion based on the commonly used compensation model for undoped SI GaAs materials is presented to interpret the experimental data. A technique for applying electrical contacts to SI GaAs materials by ultrasonic soldering has been developed to achieve reproducible measurements. Although only GaAs materials were investigated, this optically assisted imperfection profile can be applied to study other high-resistivity semiconductors.
Advanced‐stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q (1997)

We have analyzed 30 cases of advanced-stage cervical squamous cell carcinoma (stages IIb–IV) by comparative genomic hybridization (CGH). The most consistent chromosomal gain in the aneuploid tumors was mapped to chromosome arm 3q in 77% of the cases. Acquisition of genetic material also occurred frequently on 1q (47%), 5p (30%), 6p (27%), and 20 (23%). Recurrent losses were mapped on 2q (33%), 3p (50%), 4 (33%), 8p (23%), and 13q (27%). High-level copy number increases were mapped to chromosome 8, chromosome arms 3q, 5p, 8q, 12p, 14q, 17q, 19q, 20p, and 20q, and chromosomal bands 3q26-27, 9p23-24, 11q22-23, and 12p13. In the majority of the cases, the presence of high-risk human papilloma virus genomes was detected. High proliferative activity was accompanied by crude aneuploidy. Increased p21/WAF-1 activity, but low or undetectable expression of TP53 were representative for the immunophenotype. This study confirms the importance of a gain of chromosome arm 3q in cervical carcinogenesis and identifies additional, recurrent chromosomal aberrations that are required for progression from stage I tumors to advanced-stage carcinomas. Genes Chromosom. Cancer 19:233–240, 1997. Published 1997 Wiley-Liss, Inc.
Alveolar Capillary Dysplasia (2011)

Alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD/MPV) is a rare, fatal developmental lung disorder of neonates and infants. This review aims to address recent findings in the etiology and genetics of ACD/MPV and to raise awareness of this poorly known disease, which may also present as milder, unclassified forms. Successively discussed are what is known about the epidemiology, pathogenesis, pathophysiology, diagnostic indicators and approaches, genetic testing, treatment, and cases of delayed onset. The review concludes with suggestions for future directions to answer the many unknowns about this disorder.
Proprioception calibrates object size constancy for grasping but not perception in limited viewing conditions (2017)

Observers typically perceive an object as being the same size even when it is viewed at different distances. What is seldom appreciated, however, is that people also use the same grip aperture when grasping an object positioned at different viewing distances in peripersonal space. Perceptual size constancy has been shown to depend on a range of distance cues, each of which will be weighted differently in different viewing conditions. What is not known, however, is whether or not the same distance cues (and the same cue weighting) are used to calibrate size constancy for grasping. To address this question, participants were asked either to grasp or to manually estimate (using their right hand) the size of spheres presented at different distances in a full-viewing condition (light on, binocular viewing) or in a limited-viewing condition (light off, monocular viewing through a 1 mm hole). In the full-viewing condition, participants showed size constancy in both tasks. In the limited-viewing condition, participants no longer showed size constancy, opening their hand wider when the object was closer in both tasks. This suggests that binocular and other visual cues contribute to size constancy in both grasping and perceptual tasks. We then asked participants to perform the same tasks while their left hand was holding a pedestal under the sphere. Remarkably, the proprioceptive cues from holding the pedestal with their left hand dramatically restored size constancy in the grasping task but not in the manual estimation task. These results suggest that proprioceptive information can support size constancy in grasping when visual distance cues are severely limited, but such cues are not sufficient to support size constancy in perception. Meeting abstract presented at VSS 2017
Analysis of Three-Electrode Setups for AC-Impedance Measurements on Lithium-Ion Cells by FEM simulations (2011)

Electrochemical impedance spectroscopy is a well-established method for investigating electrode processes in lithium-ion cells. Commonly, a three-electrode setup is used, with a reference electrode positioned at the rim of the separator and centered between working and counter electrode. The reliability of this setup is evaluated theoretically by using finite-element calculations and experimentally by using LiFePO4 and lithium-metal electrodes in symmetrical and mixed arrangements measured as half-cells and full-cells. The results show that asymmetries between working and counter electrode arising from electrode misalignment and/or different electrode characteristics, adulterate the reference electrode potential. In consequence, errors such as quantitative scaling factors and cross contamination of electrode impedance response arise and inductive artifacts develop. Furthermore, we assess the impedance distortion quantitatively for different ratios of electrolyte and electrode resistances.
Remote Temperature Distribution Sensing Using Permanent Magnets (2016)

Remote temperature sensing is essential for applications in enclosed vessels, where feedthroughs or optical access points are not possible. A unique sensing method for measuring the temperature of multiple closely spaced points is proposed using permanent magnets and several three-axis magnetic field sensors. The magnetic field theory for multiple magnets is discussed and a solution technique is presented. Experimental calibration procedures, solution inversion considerations, and methods for optimizing the magnet orientations are described in order to obtain low-noise temperature estimates. The experimental setup and the properties of permanent magnets are shown. Finally, experiments were conducted to determine the temperature of nine magnets in different configurations over a temperature range of 5 °C to 60 °C and for a sensor-to-magnet distance of up to 35 mm. To show the possible applications of this sensing system for measuring temperatures through metal walls, additional experiments were conducted inside an opaque 304 stainless steel cylinder.
A Model for Water Injection into Frac-Packed Wells (2007)

Abstract Description of the material A model is presented for predicting the performance of water injection wells with frac-packed completions. The model estimates the plugging of the frac-pack because of solids in the injected water and its effect on the frac-pack completion. It takes into account the thermal stresses caused by cold water injection and pore pressure changes. Application Frac-packs are increasingly being used for sand control in injection wells in poorly consolidated reservoirs. These completions allow for large injection rates and longer injector life. Many of the large off-shore developments in the Gulf of Mexico and around the world rely on these completions for water flooding and pressure maintenance. The performance of these injectors is crucial to the economics of the project since well intervention later in the life of the field is expensive and undesirable. Results, Observations, and Conclusions Injector performance is shown to depend on the solids content in the injected water, proppant size in the frac-pack, initial width and length of the frac-pack, injection rate, injection water temperature and the minimum horizontal stress. In cases with wide and conductive frac-packs, the plugging of the frac-pack will be gradual and the injectivity would remain high. In cases where significant plugging may occur, a rapid rise in the bottom-hole pressure will result in sharp decline of initial injectivity. However the frac-packs will widen up after the bottom hole pressure reaches a critical pressure because of a high permeability channel through the frac-pack which will alleviate the injectivity decline. Significant New Contributions A model for water injection into frac-packed wells is presented for the first time. It accounts for plugging of the frac-pack and the formation around, thermal stresses caused by cold water injection and frac-pack widening and/or lengthening.
Quasi-breakdown of ultrathin gate oxide under high field stress (2002)

A new oxide failure mode of ultrathin gate oxide is reported. During high constant current stressing, V/sub G/ variation with time shows two distinct modes, i.e., a stable mode and a fluctuation mode named as quasi-breakdown. Once the quasi-breakdown starts, gate current in low field abruptly increases. From the experimental results, it could be concluded that the quasi-breakdown occurs when injected electrons travel in the oxide conduction band ballistically. Localized physical damage near the Si/SiO/sub 2/ interface is believed to be the cause of the quasi-breakdown, The great increase of gate current after the quasi-breakdown was modeled by a superposition of F-N tunneling current and direct tunneling current with a finite series resistance, and a good agreement has been found.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Practice effects in multiple neuropsychological assessments (1992)

Journal Article Practice effects in multiple neuropsychological assessments Get access R.J. McCaffrey, R.J. McCaffrey The University at Albany, State University of New York Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Ortega, A. Ortega The University at Albany, State University of New York Search for other works by this author on: Oxford Academic PubMed Google Scholar S.M. Orsillo, S.M. Orsillo The University at Albany, State University of New York Search for other works by this author on: Oxford Academic PubMed Google Scholar R.F. Haase R.F. Haase The University at Albany, State University of New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Archives of Clinical Neuropsychology, Volume 7, Issue 4, 1992, Page 345, https://doi.org/10.1093/arclin/7.4.345 Published: 01 July 1992
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe (2019)

Inhibiting the RAS oncogenic protein has largely been through targeting the switch regions that interact with signalling effector proteins. Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isoform by binding to an allosteric site encompassing the region around KRAS-specific residue histidine 95 at the helix α3/loop 7/helix α4 interface. We show that these DARPins specifically inhibit KRAS/effector interactions and the dependent downstream signalling pathways in cancer cells. Binding by the DARPins at that region influences KRAS/effector interactions in different ways, including KRAS nucleotide exchange and inhibiting KRAS dimerization at the plasma membrane. These results highlight the importance of targeting the α3/loop 7/α4 interface, a previously untargeted site in RAS, for specifically inhibiting KRAS function.
Efficient learning of multi-step best response (2005)

We provide a uniform framework for learning against a recent history adversary in arbitrary repeated bimatrix games, by modeling such an agent as a Markov Decision Process. We focus on learning an optimal non-stationary policy in such an MDP over a finite horizon and adapt an existing efficient Monte Carlo based algorithm for learning optimal policies in such MDPs. We show that this new efficient algorithm can obtain higher average rewards than a previously known efficient algorithm against some opponents in the contract game. Though this improvement comes at the cost of increased domain knowledge, a simple experiment in the Prisoner's Dilemma game shows that even when no extra domain knowledge (besides that the opponent's memory size is known) is assumed, the error can still be small.
Rehabilitative Interventions and Brain Plasticity in Autism Spectrum Disorders: Focus on MRI-Based Studies (2016)

Clinical and research evidence supports the efficacy of rehabilitative intervention for improving targeted skills or global outcomes in individuals with autism spectrum disorder (ASD). However, putative mechanisms of structural and functional brain changes are poorly understood. This review aims to investigate the research literature on the neural circuit modifications after non-pharmacological intervention. For this purpose, longitudinal studies that used magnetic resonance imaging (MRI)-based techniques at the start and at the end of the trial to evaluate the neural effects of rehabilitative treatment in subjects with ASD were identified. The six included studies involved a limited number of patients in the active group (from 2 to 16), and differed by acquisition method (task-related and resting-state functional MRI) as well as by functional MRI tasks. Overall, the results produced by the selected investigations demonstrated brain plasticity during the treatment interval that results in an activation/functional connectivity more similar to those of subjects with typical development (TD). Repeated MRI evaluation may represent a promising tool for the detection of neural changes in response to treatment in patients with ASD. However, large-scale randomized controlled trials after standardized rehabilitative intervention are required before translating these preliminary results into clinical use.
2.3 kVac 100 MHz multi-channel monolithic isolator IC (2002)

We have developed a multi-channel monolithic isolator IC that can provide 2.3 kVac isolation and 100 MHz signal transmission. This IC uses high voltage on-chip isolator technology using trench isolation with buried oxide on the SOI substrate and 0.4 /spl mu/m CMOS driver and receiver circuits. This technology enables to produce a 4-channel monolithic isolator with an area of 1.5 mm/sup 2/ and a consumption current of 0.5 mA per channel at a frequency of 50 MHz. We have also developed a one-chip modem interface IC that includes the multi-channel isolator and an analog front-end circuit.
Lost in translation: pluripotent stem cell‐derived hematopoiesis (2015)

Pluripotent stem cells (PSCs) such as embryonic stem cells or induced pluripotent stem cells represent a promising cell type to gain novel insights into human biology. Understanding the differentiation process of PSCs in vitro may allow for the identification of cell extrinsic/intrinsic factors, driving the specification process toward all cell types of the three germ layers, which may be similar to the human in vivo scenario. This would not only lay the ground for an improved understanding of human embryonic development but would also contribute toward the generation of novel cell types used in cell replacement therapies. In this line, especially the developmental process of mesodermal cells toward the hematopoietic lineage is of great interest. Therefore, this review highlights recent progress in the field of hematopoietic specification of pluripotent stem cell sources. In addition, we would like to shed light on emerging factors controlling primitive and definitive hematopoietic development and to highlight recent approaches to improve the differentiation potential of PSC sources toward hematopoietic stem/progenitor cells. While the generation of fully defined hematopoietic stem cells from PSCs remains challenging in vitro, we here underline the instructive role of cell extrinsic factors such as cytokines for the generation of PSC-derived mature hematopoietic cells. Thus, we have comprehensively examined the role of cytokines for the derivation of mature hematopoietic cell types such as macrophages, granulocytes, megakaryocytes, erythrocytes, dendritic cells, and cells of the B- and T-cell lineage.