gebhart/patrepeval huggingface dataset:
Aeroelastic Analysis of NREL Wind Turbine (2017)

The current development of wind turbines is moving toward larger and more flexible units, which can make them prone to fatigue damage induced by aeroelastic vibrations. The estimation of the total life of the composite components in a wind turbine requires the knowledge of both low and high cycle fatigue (LCF and HCF) data. The first aim of this study is to produce a validated numerical model, which can be used for aeroelastic analysis of wind turbines and is capable of estimating the LCF and HCF loads on the blade. The second aim of this work is to use the validated numerical model to assess the effects of extreme environmental conditions (such as high wind speeds) and rotor over-speed on low and high cycle fatigue. Numerical modelling of this project is carried out using the Computational Fluid Dynamics (CFD) & aeroelasticity code AU3D, which is written at Imperial College and developed over many years with the support from Rolls-Royce. This code has been validated extensively for unsteady aerodynamic and aeroelastic analysis of high-speed flows in gas turbines, yet, has not been used for low-speed flows around wind turbine blades. Therefore, in the first place the capability of this code for predicting steady and unsteady flows over wind turbines is studied. The test case used for this purpose is the Phase VI wind turbine from the National Renewable Energy Laboratory (NREL), which has extensive steady, unsteady and mechanical measured data. From the aerodynamic viewpoint of this study, AU3D results correlated well with the measured data for both steady and unsteady flow variables, which indicated that the code is capable of calculating the correct flow at low speeds for wind turbines. The aeroelastic results showed that increase in crosswind and shaft speed would result in an increase of unsteady loading on the blade which could decrease the lifespan of a wind turbine due to HCF. Shaft overspeed leads to significant increase in steady loading which affects the LCF behaviour. Moreover, the introduction of crosswind could result in significant dynamic vibration due to forced response at resonance.
Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations (2005)

The blood-brain barrier (BBB) maintains brain homeostasis by limiting entry of substances to the central nervous system through interaction of transmembrane and intracellular proteins that make up endothelial cell tight junctions (TJs). Recently it was shown that the BBB can be modulated by disease pathologies including inflammatory pain. This study examined the effects of chronic inflammatory pain on the functional and molecular integrity of the BBB. Inflammatory pain was induced by injection of complete Freund's adjuvant (CFA) into the right plantar hindpaw in female Sprague-Dawley rats under halothane anesthesia; control animals were injected with saline. Edema and hyperalgesia were assessed by plethysmography and infrared paw-withdrawal latency. At 72 h postinjection, significant edema formation and hyperalgesia were noted in the CFA-treated rats. Examination of permeability of the BBB by in situ perfusion of [14C]sucrose while rats were under pentobarbital anesthesia demonstrated that CFA treatment significantly increased brain sucrose uptake. Western blot analysis of BBB TJ proteins showed no change in expression of zonula occludens-1 (an accessory protein) or actin (a cytoskeletal protein) with CFA treatment. Expression of the transmembrane TJ proteins occludin and claudin-3 and -5 significantly changed with CFA treatment with a 60% decrease in occludin, a 450% increase in claudin-3, and a 615% increase in claudin-5 expression. This study demonstrates that during chronic inflammatory pain, alterations in BBB function are associated with changes in specific transmembrane TJ proteins.
Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders (2014)

Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.
Long-term stimulation by active epiretinal implants in normal and RCD1 dogs (2005)

An epiretinal prosthesis, consisting of an extraocular microelectronic stimulator and an intraocular electrode array, was implanted in one eye of three blind and three sighted dogs. Three dogs (2 blind, 1 normal) were stimulated for 120 days, and two dogs (both normal) for 60 and 103 days respectively for 8-10 h/day at levels of 0.1 mC cm(-2) and 0.05 mC cm(-2), with each stimulus level presented to half of the array. One blind dog was kept as an inactive implant control. During the study period, electroretinograms (ERG) and fundus photographs were recorded. At the end of the study period, the dogs were sacrificed and histological and morphometric evaluation was made of the retina. No inflammatory reaction, neovascularization or hemorrhage was observed during the follow-up examinations. ERGs were unchanged. Stimulus levels used were of sufficient amplitude to elicit cortical evoked potentials. Histological evaluation showed no inflammatory infiltrates or changes in retina morphometry related to electrical stimulation when compared to the unstimulated control eye. Morphometric analysis revealed no consistent differences relating to electrical stimulation. In summary, chronic electrical stimulation of the dog retina at up to 0.1 mC cm(-2) with an epiretinal prosthesis does not appear to adversely affect the retina.
Functional polyesters derived from alternating copolymerization of norbornene anhydride and epoxides (2015)

Alternating polymerization of norbornene containing polyesters and their functionalization.
Generating fuzzy rules from data (2002)

This paper introduces an effective method of developing fuzzy rules from continuous valued data. The fuzzy rules may be used for control applications without tuning. The fuzzy rules are created by exploiting the properties of decision trees, as embodied by the C4.5 decision tree learning system. A crisp decision tree is created by creating a discrete set of fuzzy output classes and providing a set of training examples to C4.5. Fuzzy rules are then extracted from the decision tree. The fuzzy rule learning system has been applied to chemical plant start-up control and the Box-Jenkins gas furnace prediction problem. Comparisons are made to fuzzy rule sets created by others for these problems. The learned rules are able to provide smooth control.
Effect of Cell-Cell Interactions on Drug Sensitivity and Growth of Drug-Sensitive and -Resistant Tumor Cells in Spheroids (1984)

Multicellular spheroids were grown from mixtures of rat brain tumor cells sensitive (9L) and resistant (R3) to 1,3-bis(2-chloroethyl)-1-nitrosourea. Percentages of each cell subpopulation in these spheroids were estimated with the sister chromatid exchange assay and were found to be approximately the same as those used to initiate spheroids. Spheroids grown from 9L cells alone had a higher growth rate than spheroids grown from R3 cells alone. However, the growth rate of mixed-cell spheroids was essentially the same as that of pure 9L spheroids and was independent of the percentages of R3 cells in mixed-cell spheroids. The sensitivity of 9L cells in mixed-cell spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea, estimated by changes in the number of sister chromatid exchanges per metaphase induced by treatment, decreased as the percentage of R3 cells increased. These effects are probably the result of an interaction between the two cell subpopulations held in three-dimensional contact, a situation similar to that in tumors in situ. The results suggest why one cell subpopulation of tumors does not become dominant during growth and indicate that interactions between cell subpopulations can influence the sensitivity of one subpopulation to 1,3-bis(2-chloroethyl)-1-nitrosourea.
Primary structure of protective antigens of type 24 streptococcal M protein. (1980)

IThe abbreviations used are: pep M24, peptic extract of type 24 streptococcal M protein; CNBr, cyanogen bromide; CB1-7, cyanogen bromide peptides of pep M24; TPCK, ~-(l-tosylamido-2-
Splenomegaly Segmentation using Global Convolutional Kernels and Conditional Generative Adversarial Networks (2017)

Spleen volume estimation using automated image segmentation technique may be used to detect splenomegaly (abnormally enlarged spleen) on Magnetic Resonance Imaging (MRI) scans. In recent years, Deep Convolutional Neural Networks (DCNN) segmentation methods have demonstrated advantages for abdominal organ segmentation. However, variations in both size and shape of the spleen on MRI images may result in large false positive and false negative labeling when deploying DCNN based methods. In this paper, we propose the Splenomegaly Segmentation Network (SSNet) to address spatial variations when segmenting extraordinarily large spleens. SSNet was designed based on the framework of image-to-image conditional generative adversarial networks (cGAN). Specifically, the Global Convolutional Network (GCN) was used as the generator to reduce false negatives, while the Markovian discriminator (PatchGAN) was used to alleviate false positives. A cohort of clinically acquired 3D MRI scans (both T1 weighted and T2 weighted) from patients with splenomegaly were used to train and test the networks. The experimental results demonstrated that a mean Dice coefficient of 0.9260 and a median Dice coefficient of 0.9262 using SSNet on independently tested MRI volumes of patients with splenomegaly.
Available fail-safe systems (2002)

Continuity of service and cost-effectiveness are adding new challenges to life critical systems over and above the underlying safety concerns. The introduction of redundant components is a necessary condition for increasing the overall system availability with respect to physical component failures. Here we consider redundancy by means of replicating fail-safe components in a distributed real-time system for railway applications. In such a system, some functions cannot tolerate even a brief service interruption. These functions have to be replicated using active redundancy, and their outputs must be consolidated with the goal that the failure of one component has no effect on the delivered service. We formally investigate conditions for preserving safety properties of fail-safe components when replicating them using active redundancy. We focus our analysis on duplex computers with two fail-safe units. Given some safety constraints, we show that inconsistency of replicated units can lead to safety degradation even if each replicated component (taken individually) satisfies the given safety constraints. Two solutions are studied: masking and detection of state or context inconsistency. The former leads to requirements on the output consolidation function and the latter to requirements on the redundancy management mechanisms.
Indoor Air Quality Survey of Nail Salons in Boston (2013)

Employees in nail salons, largely Vietnamese immigrant women in Boston, are exposed to a range of volatile organic chemicals from the products used in salons, including solvents, glues and polishes. Some of these chemicals have the potential to cause short and long-term adverse health effects. Only limited research has been performed on assessing occupational exposures. This project aimed to characterize total volatile organic compound (TVOC) and PM2.5 concentrations in nail salons as a function of ventilation, building characteristics, customer and employee occupancy, and type of services being performed. Students conducted sampling in 21 salons in Boston, MA from September to December, 2011. Study visits included: indoor environmental quality measurements (TVOCs, PM2.5 and carbon dioxide), site observations, and an interview. CO2 levels in 15 of 21 salons exceeded 800 ppm, suggesting that these salons may have insufficient ventilation. Higher TVOC and PM2.5 levels were found in salons with less ventilation (as estimated using CO2 concentrations). Contrary to our a priori hypothesis, average levels of TVOCs, CO2 and PM2.5 were consistent throughout salons, indicating that exposures may not be restricted to areas in the salon where work is being performed (e.g., at the manicure table). Higher TVOC concentrations were observed when tasks were being performed, yet were not dependent upon the number of tasks being performed. Improving ventilation conditions in salons to meet minimum outdoor air delivery requirements can reduce exposures to TVOCs.
Noncontact Monitoring of Vital Signs with RGB and Infrared Camera and Its Application to Screening of Potential Infection (2018)

In recent years, much attention is being paid to research and development of technology that provides noncontact measurement of vital signs, i.e., heart rate, respiration, and body temperature, which are important for understanding the state of a person’s health. As technology for sensing biological information has progressed, new biological measurement sensors have been developed successively. There have also been reports regarding methods for measuring respiration or heart rate using pressure sensors, microwave radar, air mattresses, or high-polymer piezoelectric film. The methods have wide-ranging applications, including systems for monitoring of elderly people, identification of sleep apnea, detection of patients suspected to have an infectious disease, and noncontact measurement of stress levels. In this chapter, the principles behind noncontact measurement of respiration and heartbeat using infrared/RGB facial-image analysis are discussed, along with the applications for such measurement in the detection of patients suspected to be suffering from infectious diseases.
An Abstract Application Layer Interface to Transport Services (2020)

This document describes an abstract programming interface to the
transport layer, following the Transport Services Architecture. It
supports the asynchronous, atomic transmission of messages over
transport protocols and network paths dynamically selected at runtime.
It is intended to replace the traditional BSD sockets API as the
lowest common denominator interface to the transport layer, in an
environment where endpoints have multiple interfaces and potential
transport protocols to select from.
Involvement of Th2 cytokines in the mouse model of flutamide‐induced acute liver injury (2011)

Drug-induced liver injury is a growing concern for pharmaceutical companies and patients because numerous drugs have been linked to hepatotoxicity and it is the most common reason for a drug to be withdrawn. Flutamide rarely causes liver dysfunction in humans, and immune allergic reactions have been suggested in some cases. In this study, we investigated the mechanisms of flutamide-induced liver injury in BALB/c mice. Plasma alanine aminotransferase and aspartate aminotransferase levels were significantly increased 3, 6 and 9 h after flutamide (1500 mg kg⁻¹ , p.o.) administration. The biomarker for oxidative stress was not changed, but Th2-dominant immune-related factors, such as interleukin (IL)-4, IL-5, STAT6 and GATA-binding protein (GATA)-3, were induced in flutamide-administered mice. The pre-administration of monoclonal-IL-4 antibody suppressed the hepatotoxicity of flutamide. In addition, we investigated the effect of 13,14-dihydro-15-keto-PGD₂ (DK-PGD₂; 10 µg per mouse, i.p.) administration on flutamide-induced acute liver injury. Coadministration of DK-PGD₂ and flutamide resulted in a significant increase in alanine aminotransferase and a remarkable increase of macrophage inflammatory protein-2. In conclusion, we demonstrated that flutamide-induced acute liver injury is mediated by Th2-dominant immune responses in mice.
Een ontdekking in de Peel: de uil Xestia stigmatica nieuw voor Nederland (Lepidoptera: Noctuidae). (2007)

A discovery in De Peel: the noctuid moth Xestia stigmatica new for the Netherlands\n(Lepidoptera: Noctuidae)\nXestia stigmatica is present all over Europe, but was not recorded in the Netherlands. In 2001 a\nsingle female was caught at light, in the commune of Deurne (province of Noord-Brabant). The\nsite is located in De Peel, a large peat area, which has been largely exploited in the past. Thanks\nto huge efforts to find more specimens, a second female was caught at syrup in 2007, close to\nthe first site. We tentatively consider the two females vagrants, although it cannot be excluded\nthat a small population exists near Deurne.
Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology (2016)

Circulating tumor cells (CTCs) are emerging as rare but clinically significant non-invasive cellular biomarkers for cancer patient prognosis, treatment selection, and treatment monitoring. Current CTC isolation approaches, such as immunoaffinity, filtration, or size-based techniques, are often limited by throughput, purity, large output volumes, or inability to obtain viable cells for downstream analysis. For all technologies, traditional immunofluorescent staining alone has been employed to distinguish and confirm the presence of isolated CTCs among contaminating blood cells, although cells isolated by size may express vastly different phenotypes. Consequently, CTC definitions have been non-trivial, researcher-dependent, and evolving. Here we describe a complete set of objective criteria, leveraging well-established cytomorphological features of malignancy, by which we identify large CTCs. We apply the criteria to CTCs enriched from stage IV lung and breast cancer patient blood samples using the High Throughput Vortex Chip (Vortex HT), an improved microfluidic technology for the label-free, size-based enrichment and concentration of rare cells. We achieve improved capture efficiency (up to 83%), high speed of processing (8 mL/min of 10x diluted blood, or 800 μL/min of whole blood), and high purity (avg. background of 28.8±23.6 white blood cells per mL of whole blood). We show markedly improved performance of CTC capture (84% positive test rate) in comparison to previous Vortex designs and the current FDA-approved gold standard CellSearch assay. The results demonstrate the ability to quickly collect viable and pure populations of abnormal large circulating cells unbiased by molecular characteristics, which helps uncover further heterogeneity in these cells.
BODIPY-based macromolecular photosensitizer with selective recognition and enhanced anticancer efficiency (2014)

Photodynamic therapy (PDT) is attracting ongoing attention for treatment of cancer as a noninvasive technique. A BODIPY-based macromolecular photosensitizer, p(GEMA-co-BODIPYMA)-2I, with high water solubility, specificity recognition to cancer cells and no dark cytotoxicity was prepared, which achieved enhanced therapeutic efficacy and reduced side-effects. P(GEMA-co-BODIPYMA)-2I generated 1O2 (ΦΔ = 0.79) rapidly in aqueous system and confocal laser scanning microscopy (CLSM) images showed that p(GEMA-co-BODIPYMA)-2I was avidly taken up specifically by cancer cells, however, couldn't be uptaken by normal cells. The novel photosensitizer displayed high photocytotoxicity for cancer cells, but not normal cells. The cell viability of normal cells was over 80% when the concentration was 20 nmol mL−1 under illumination for 10 min and that for cancer cells was 0.4% under the same conditions. Our facile strategy provides a novel avenue for the effective development of photosensitizers for cancer therapy.
Design and measurements of Ka-band waveguide dielectric rod antenna for 7 channel digital beamformer for HAPS (2005)

HAPS system is required to have strict specification to reduce the interference between adjacent cells. One of the most efficient ways to suppress the grating lobe in visible rang is to shape FTEP (flat-topped element pattern). This work presents the design and experimental results of 7 waveguide dielectric rod array antennas for shaping FTEP in the Ka-band. The calculated element pattern and the measured element pattern are also compared. This prototype antenna will be applied to the multibeam antenna to generate 7 beams using digital beamformer.
The firing of hippocampal place cells in the dark depends on the rat's recent experience (1990)

Hippocampal "place cells" fire when a freely moving rat is in a given location. The firing of these cells is controlled by visual and nonvisual environmental cues. The effects of darkness on the firing of place cells was studied using the task of Muller et al. (1987), in which rats were trained to chase randomly scattered food pellets in a cylindrical drum with a white cue-card attached to the wall. The position of the rats was tracked via an infrared LED on the headstage with a video system linked to computer. Two experimental protocols were used: in the first, lights were turned off after the rat had already been placed in the chamber; in the second, the rat was placed in the darkened chamber. The dark segments produced by these 2 methods were identical with respect to light and other cues but differed with respect to the rat's experience. The firing patterns of 24 of 28 cells were unaffected by darkness when it was preceded by a light period. In contrast, the firing patterns of 14 of 22 cells changed dramatically when the rats were put into the darkened chamber. Furthermore, the majority of cells that changed their firing pattern in initial darkness maintained that change when the lights were turned on. These results show that place cells can fire differently in identical cue situations and that the best predictor of firing pattern is a combination of current cues and the rat's recent experience. The results are discussed in terms of mnemonic properties of hippocampal cells and "remapping" of place cell representations.
ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction (2005)

Chromosome 20q13.2 is amplified in 20-30% of early-stage breast tumors and is associated with poor prognosis. Detailed mapping of the amplified region using molecular cytogenetics, positional cloning and genomic sequencing culminated in a detailed molecular description of the candidate oncogene ZNF217. ZNF217 proteins resemble Kruppel-like transcription factors, localize predominately to the nucleus and associate with proteins involved in transcriptional repression. The findings that ZNF217 can immortalize human mammary epithelial cells and that its amplification is associated with poor prognosis suggest that it may play roles in both early- and late-stage breast cancer. We present evidence that ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction as well as from doxorubicin-induced DNA damage and that silencing ZNF217 with siRNA restores sensitivity to doxorubicin. Moreover, elevated ZNF217 leads to increased phosphorylation of Akt, whereas inhibition of the phosphatidylinositol 3 kinase pathway and Akt phosphorylation decreases ZNF217 protein levels and increases sensitivity to doxorubicin. These results suggest that ZNF217 may promote neoplastic transformation by increasing cell survival during telomeric crisis and may promote later stages of malignancy by increasing cell survival during chemotherapy.
Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. (2009)

In conclusion, the present study found that 5 grams of capsicum presented capsaicin levels that were associated with a decrease in plasma glucose levels and the maintenance of insulin levels. The present result might have clinical implications in the management of type 2 diabetes.