gebhart/patrepeval huggingface dataset:
[Analysis of cell surface antigens of gastric cancer and preliminary study of clinical application by using mouse monoclonal antibodies produced against NUGC3]. (1985)

Four monoclonal antibodies (GC301, 302, 303, 304) produced by hybridomas obtained from mice immunized with NUGC3 were analyzed by serological assay (Mixed Hemadsorption Assay-MHA) and immunoperoxidase technique. GC301(IgG1) showed tumor restricted reactivity in serological analysis, but it reacted with fibrous interstitial tissues immunohistochemically. GC302(IgG1) was serologically reactive with epithelial tumors such as gastric cancers, colon cancers and gynecological cancers, but not with brain tumors, melanomas and other normal cells. In tissue sections, all gastric cancers, intestinal metaplasia, stomach of fetus and bile duct were stained, but brain and hepatocytes were not. These results indicate that the antigen detected by GC302 is not only differentiation antigen by which gastrointestinal tract could be divided into foregut and midgut origins, but also the new type of oncofetal antigen different from CEA. GC302 would be useful for preoperative detection of gastric cancer in lymph nodes, using radioimmunodetection scans. GC303(IgG1) and GC304(IgG1) were broadly reactive with various cells in serological assay. Immunohistochemically, GC304 reacted with submucosal connective tissue, which was inhibited by collagenase. The results obtained from GC301 and GC304 suggest the possibility of interaction between tumor cells and interstitial tissues.
Integrated multimodal endomicroscopy platform for simultaneous en face optical coherence and two-photon fluorescence imaging (2012)

We report an all-fiber-optic scanning, multimodal endomicroscope capable of simultaneous optical coherence tomography (OCT) and two-photon fluorescence (TPF) imaging. Both imaging modalities share the same miniature fiber-optic scanning endomicroscope, which consists of a double-clad fiber with a core operating in single mode at both the OCT (1310 nm) and two-photon excitation (1550 nm) wavelengths, a piezoelectric two-dimensional fiber-optic beam scanner, and a miniature aspherical compound lens suitable for simultaneous acquisition of en face OCT and TPF images. A fiber-optic wavelength division multiplexer was employed in the integrated platform to combine the low coherence OCT light source and the femtosecond two-photon excitation laser into the same optical path. Preliminary imaging results of cell cultures and mouse tissue ex vivo demonstrate the feasibility of simultaneous real-time OCT and TPF imaging in a scanning endomicroscopy setting for the first time.
Performance Isolation in Multi-Tenant Applications (2015)

The thesis presents methods to isolate different tenants, sharing one application instance, with regards to he performance they observe. Therefore, a request based admission control is introduced. Furthermore, the publication presents methods and novel metrics to evaluate the degree of isolation a system achieves. These insights are used to evaluate the developed isolation methods, resulting in recommendations of methods for various scenarios.
MR properties of brown and white adipose tissues (2011)

We have demonstrated that there are several key MR-based signatures of BAT and WAT that may allow differentiation on MR imaging.
Penetration and entrapment of large particles in erythrocytes by electrical breakdown techniques. (1978)

Human erythrocytes suspended in isotonic solutions were subjected to haemolysis by application of an electric field pulse to the cell suspension. The field strengths used were 12 and 16kV/cm, respectively; the pulse duration 40 microseconds. The lysed cells showed resealing properties. The permeability change of the membrane generated by the field pulse and by the subsequent osmotic processes were large enough to facilitate the penetration and entrapment of ferritin and Latex particles (diameter: 0.091 and 0.176 micron, respectively) as revealed by electron microscopy. Correct identification of the Latex particles in the electron-micrographs indicated that LOYTER et al. [J. Cell Biol. 66, 292 (1975)], who recently demonstrated the entrapment of Latex spheres in erythrocytes prepared by osmotic haemolysis mistook electron-dense bodies probably consisting of denaturated protein for Latex particles. Under conditions of osmotic haemolysis, carried out according to BODEMANN and PASSOW, particles could only occasionally be detected within the membrane itself and never within the cell interior, suggesting that the electrical haemolysis method is much more effective in the generation of large holes in the membrane.
Identification of a mutation in the pst-phoU operon that reduces pathogenicity of an Escherichia coli strain causing septicemia in pigs (1995)

We used transposon (TnphoA) mutagenesis to study the role of virulence factors of pathogenic Escherichia coli strains associated with septicemia in calves and piglets. We have produced an avirulent and serum-sensitive mutant of wild-type pathogenic strain 5131 O115:K"V165":F165 and have localized and identified the TnphoA insertion in the pstC gene of the pst-phoU operon. This operon encodes the PstSCAB transporter and PhoU protein that negatively regulate the phosphate (Pho) regulon. This mutation is pleiotropic and could have an effect on pathogenicity and on the production of the surface polysaccharides of strain 5131. The mutant demonstrated restored repressibility of alkaline phosphatase and regained the capacity to resist serum and to survive systemically for at least 5 days in experimentally inoculated pigs when complemented with plasmid pAN92, bearing the pst-phoU operon.
Waveguide-Coupled Rydberg Spectrum Analyzer from 0 to 20 GHz (2021)

We demonstrate an atomic rf receiver and spectrum analyzer based on thermal Rydberg atoms coupled to a planar microwave waveguide. We use an off-resonant rf heterodyne technique to achieve continuous operation for carrier frequencies ranging from dc to 20 GHz. The system achieves an intrinsic sensitivity of up to $\ensuremath{-}120(2)$, dc coupling, 4-MHz instantaneous bandwidth, and over 80 dB of linear dynamic range. By connecting through a low-noise preamplifier, we demonstrate high-performance spectrum analysis with peak sensitivity of better than $\ensuremath{-}145\phantom{\rule{0.2em}{0ex}}\mathrm{dBm/Hz}$. Attaching a standard rabbit-ears antenna, the spectrum analyzer detects weak ambient signals including FM radio, AM radio, WiFi, and bluetooth. We also demonstrate waveguide-readout of the thermal Rydberg ensemble by nondestructively probing waveguide-atom interactions. The system opens the door for small, room-temperature, ensemble-based Rydberg sensors that surpass the sensitivity, bandwidth, and precision limitations of standard rf sensors, receivers, and analyzers.
Plasma viremia in human immunodeficiency virus infection: relationship to stage of disease and antiviral treatment. (1992)

Quantitative culture of human immunodeficiency virus (HIV) was performed on 121 plasma samples from 76 HIV-infected individuals to determine the sensitivity of the assay at different stages of disease and to measure the effect of antiviral therapy on plasma viremia. Plasma virus was detected in 49 of 76 (64%) of patients, primarily those with AIDS and AIDS-related complex (36 of 38) versus asymptomatic subjects (13 of 38) (p less than 0.001, chi 2). Similarly, plasma cultures were more often positive in patients with less than 250 CD4+ T cells per microliter (38 of 40) than in those with greater than 250 CD4+ T cells per microliter (11 of 36) (p less than 0.001, chi 2). Plasma virus cultures were also more likely to be positive in patients with detectable serum p24 antigen (24 of 26) than in those without detectable p24 antigen (25 of 50) (p = 0.0023, chi 2). An effect of zidovudine (ZDV) treatment on plasma viremia was seen in a comparison of treated and untreated patients with less than 250 CD4+ T cells per microliter. Geometric mean titers of plasma viremia from 16 patients treated with ZDV for more than 3 months were significantly lower than titers from 24 untreated patients (10(1.3) versus 10(2.1), p less than 0.05, Student's t test. A comparison of pre- and posttherapy titers in 33 patients receiving antiviral treatment showed that plasma virus was not detectable at either time in 17 patients; there was a fall in plasma virus titer in 12; and titers were unchanged or increased in 4. In patients with advanced disease, plasma viremia is a potential marker of antiviral drug activity.
Secure In-Network Processing in Sensor Networks (2006)

In-network processing in large-scale sensor networks has been shown to improve scalability, eliminate information redundancy and increase the lifetime of the network. In this chapter we address the challenge of securing innetwork processing, both for aggregating sensor node’s measurements and disseminating commands from the aggregators to individual sensor nodes. We present the key mechanisms for establishing a secure communication channel between sensor nodes and aggregators and show how scalability and resiliency against different type of attacks can be achieved. We also present how requirements such as dynamically adding new nodes in the network and harmonious existence with other security protocols of the network can be met. Finally we elaborate on resilient aggregation under corrupted measurements and the proposed solutions.
Sense and nonsense in sensors (2010)

Continuous subcutaneous glucose monitoring (CGM) is a developing technology in the treatment of diabetes mellitus. The first randomised controlled trials on its efficacy have been performed. In several studies, CGM lowered HbA1c in adult patients with suboptimally controlled type 1 diabetes mellitus, when selecting compliant patients who tolerate the device. However, as a preventive tool for hypoglycaemia, CGM has not fulfilled the great expectations. Increasing reimbursement of CGM is expected in the near future, awaiting studies on cost-effectiveness.
Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine (2012)

Secreted Wnt proteins constitute one of the largest families of intercellular signaling molecules in vertebrates with essential roles in embryonic development and adult tissue homeostasis. The functional redundancy of Wnt genes and the many forms of cellular responses they elicit, including some utilizing the transcriptional co-activator β-catenin, has limited the ability of classical genetic strategies to uncover their roles in vivo. We had previously identified a chemical compound class termed Inhibitor of Wnt Production (or IWP) that targets Porcupine (Porcn), an acyltransferase catalyzing the addition of fatty acid adducts onto Wnt proteins. Here we demonstrate that diverse chemical structures are able to inhibit Porcn by targeting its putative active site. When deployed in concert with small molecules that modulate the activity of Tankyrase enzymes and glycogen synthase kinase 3 β (GSK3β), additional transducers of Wnt/β-catenin signaling, the IWP compounds reveal an essential role for Wnt protein fatty acylation in eliciting β-catenin-dependent and -independent forms of Wnt signaling during zebrafish development. This collection of small molecules facilitates rapid dissection of Wnt gene function in vivo by limiting the influence of redundant Wnt gene functions on phenotypic outcomes and enables temporal manipulation of Wnt-mediated signaling in vertebrates.
Scene Parsing Using Region-Based Generative Models (2006)

Semantic scene classification is a challenging problem in computer vision. In contrast to the common approach of using low-level features computed from the whole scene, we propose "scene parsing" utilizing semantic object detectors (e.g., sky, foliage, and pavement) and region-based scene-configuration models. Because semantic detectors are faulty in practice, it is critical to develop a region-based generative model of outdoor scenes based on characteristic objects in the scene and spatial relationships between them. Since a fully connected scene configuration model is intractable, we chose to model pairwise relationships between regions and estimate scene probabilities using loopy belief propagation on a factor graph. We demonstrate the promise of this approach on a set of over 2000 outdoor photographs, comparing it with existing discriminative approaches and those using low-level features
EP<sub>1</sub>and EP<sub>4</sub>receptors mediate prostaglandin E<sub>2</sub>actions in the microcirculation of rat kidney (2000)

Vasodilator prostaglandin PGE(2) protects the kidney from excessive vasoconstriction during contraction of extracellular fluid volume and pathophysiological states. However, it is not yet clear which of the four known E-prostanoid (EP) receptors is localized to resistance vessels and mediates net vasodilation. In the present study, we assessed the presence, signal transduction, and actions of EP receptor subtypes in preglomerular arterioles of Sprague-Dawley rat kidneys. RNA encoding EP(1), an EP(1)-variant, and EP(4) receptors was identified by RT-PCR in freshly isolated preglomerular microvessels; cultured preglomerular vascular smooth muscle cells (VSMC) had EP(1)-variant and EP(4) RNA but lacked EP(1). EP(2) and EP(3) receptors were undetectable in both vascular preparations. In studies of cell signaling, stimulation of cAMP by various receptor agonists is consistent with primary actions of PGE(2) on the EP(4) receptor, with no inhibition of cAMP by EP(1) receptors. Studies of cytosolic calcium concentration in cultured renal VSMC support an inhibitory role of EP(4) during ANG II stimulation. In vivo renal blood flow (RBF) studies indicate that the EP(4) receptor is the primary receptor mediating sustained renal vasodilation produced by PGE(2), whereas the EP(1) receptor elicits transient vasoconstriction. The EP(1)-variant receptor does not appear to possess any cAMP or cytosolic calcium signaling capable of affecting RBF. Collectively, these studies demonstrate that the EP(4) receptor is the major receptor in preglomerular VSMC. EP(4) mediates PGE(2)-induced vasodilation in the rat kidney and signals through G(s) proteins to stimulate cAMP and inhibit cytosolic calcium concentration.
Indeterminate colitis in the spectrum of inflammatory bowel disease. (1979)

During a ten-year period, a double-blind retrospective study of 32 colectomy specimens from patients with inflammatory bowel disease (IBD) showed that the majority of cases could be clearly separated into ulcerative colitis (UC, 65%) and Crohn's disease (CD, 19%). However, in five (16%) colectomy specimens, the pathologic changes did not fulfill the criteria generally accepted for UC and CD. Criteria were laid down to differentiate the indeterminate form of colitis from the two more familiar types of IBD. We discuss the value of the category "indeterminate colitis" and emphasize that the term "transmural inflammation" is loosely used and that accurate definition of this criterion removes much of the difficulty from the differential diagnosis of IBD.
Stick-On Piezoelectromagnetic AC Current Monitoring of Circuit Breaker Panels (2013)

We present a stick-on wireless electric current monitoring system that is designed to measure and report electricity usage from circuit breaker panels in residential and commercial settings. This monitoring system uses piezoelectromagnetic (PEM) AC current sensors to couple to the magnetic fields produced by the current-carrying conductors. The PEM sensors can be easily attached to the surfaces of common circuit breaker panels, facilitating the installation by non-technical individuals. This paper describes the sensing principles and provides an analytical model of the PEM AC sensors. It also presents the architecture for a wireless current monitoring system and describes its implementation for sub-metering a circuit breaker panel in a building at the University of California, Berkeley. The theory and experimental validation of a signal deconvolution and calibration method, essential for extracting signals from cross-coupled magnetic fields, are also included.
Mitochondrial adenine nucleotide carrier. Investigation of principal structural, steric, and contact requirements for substrate binding and transport by means of ribose-modified substrate analogs (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMitochondrial adenine nucleotide carrier. Investigation of principal structural, steric, and contact requirements for substrate binding and transport by means of ribose-modified substrate analogsKarl Siegfried Boos and Eckhard SchlimmeCite this: Biochemistry 1979, 18, 24, 5304–5309Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/bi00591a007https://doi.org/10.1021/bi00591a007research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fundamental Mode Orthogonal Fluxgate Magnetometer Applicable for Measurements of DC and Low-Frequency Magnetic Fields (2018)

Compatibility of low noise characteristic and offset stability is essential for a magnetometer to be applicable for measurements of dc and low-frequency magnetic fields. Fundamental mode orthogonal fluxgate (FM-OFG) magnetometer has advantages in its compact design and low noise characteristic, whereas its disadvantage is the offset drift which is unacceptably large for such measurement. An effective technique called bias switching has been proposed to suppress and stabilize the offset of open-loop FM-OFG magnetometers, yet when it is adopted with a feedback configuration to obtain better linearity, it increases noises attributed to the convergence process. In this paper, we present a design of sensor driving electronics of FM-OFG magnetometers to solve this problem and achieve compatibility of low noise and stable offset characteristics with a feedback configuration. The efficacy of the design was verified through various performance evaluations.
Biologically inspired optical structures for wide field-of-view imaging and wide angle illumination (2009)

Two optical schemes inspired by an insect are implemented to novel optical devices for wide field-of-view imaging and wide angular illumination in miniaturized optical systems, using polymer based microfabrication techniques.
Superior Performance of LiFePO<sub>4</sub>Aqueous Dispersions via Corona Treatment and Surface Energy Optimization (2012)

In lithium-ion battery electrode processing, obtaining good wetting and adhesion of the electrode dispersion to the current collector foil is essential for achieving high capacity and good long-term performance. The surface tension of LiFePO4 aqueous dispersions is much higher than the surface energy of untreated Al foil due to the high surface tension of water (72.8 mN/m), which causes inferior wetting during the coating step. In this work it has been shown that the surface energy of Al foil is significantly increased by corona plasma treatment. Consequently, the wetting and adhesion of the LiFePO4 aqueous dispersion to the Al foil are dramatically improved, as evidenced by contact angle measurements, adhesion energy calculations and interfacial tension calculations. The LiFePO4 cathodes with corona treated Al foil exhibited superior capacity (∼20 mAh/g improvement) with no increase in capacity fade at 0.5C/−0.5C cycling compared to an identical electrode without treatment.
TSMC sees bigger hit from bad photoresist (2019)

Taiwan Semiconductor Manufacturing Company is providing new details on the impact of a faulty photoresist shipped by one of its chemical suppliers. TSMC, the world’s largest contract chipmaker, says it will have to scrap more silicon wafers than it earlier estimated, leading to a drop in first-quarter sales of about $550 million. The company says a batch of photoresist contained a component that was abnormally treated, creating a foreign polymer that contaminated the wafers. Industry sources say the firm’s key photoresist suppliers are Dow Chemical, JSR, and Shin-Etsu Chemical.
Tumor Necrosis Factor Receptors Types 1 and 2 Differentially Regulate Osteoclastogenesis (2000)

The potent osteoclastogenic agent, tumor necrosis factor-α (TNF), exerts its biological effects via two receptors, namely TNF receptors 1 (p55r) and 2 (p75r), each present on osteoclast precursors. Thus, we asked if p55r and p75r differentially impact the osteoclastogenic process. Marrow derived from mice expressing only p55r generates substantially more osteoclasts, in the basal state, than does wild type, while marrow expressing only p75r, produces substantially fewer. Reflecting its preferential activation of p55r, exogenous TNF stimulates osteoclast formation by p55r<sup>+/+</sup>p75r<sup>−/−</sup>, but not p55r<sup>−/−</sup>p75r<sup>+/+</sup>, marrow. Consistent with the fact that NF-κB is essential for osteoclastogenesis, this transcription complex is activated, relative to wild type, in p55r<sup>+/+</sup>p75r<sup>−/−</sup> osteoclast precursors and suppressed in those expressing only p75r. Because p55r enhances, and p75r suppresses, osteoclastogenesis, we asked if their principal ligands, namely soluble and membrane-residing TNF, respectively, differentially impact basal osteoclast recruitment. We find, in contrast to the significant level of osteoclast formation in wild type marrow, osteoclastogenesis by that derived from mice expressing membrane, but not soluble, TNF, is negligible. Thus, optimal therapeutic inhibition of bone resorption may entail selective TNF receptor modulation and/or arrested cleavage of membrane TNF to its soluble form.
Commiphora myrrha and commiphora Africana essential oils (2014)

From generation to generation in all countries all around the world medicinal plants play an important role in our
live from ancient time till these days of wide drugs and pharmacological high technique industries , the studding of
biological and pharmacological activities of plant essential oils attracted the attention to the potential use of these
natural products from chemical and pharmacological investigation to their therapeutic aspects. In this paper two
resins commiphora Africana and commiphora myrrha were selected to discuss their essential oils for chemical
analysis and biological aspect the results of GCMS shows that the two resins are rich in sesqiuterpenes and
sesqiuterpene lactones compounds that possess anti-inflammatory and antitumor activity Antibacterial and
antifungal bioassay shows antibacterial and antifungal activity higher in the myrrha oil than the Africana oil while
antiviral bioassay shows higher antiviral activity in the Africana oil than myrrha oil