gebhart/patrepeval huggingface dataset:
Soft Sensing of Nonlinear and Multimode Processes Based on Semi-Supervised Weighted Gaussian Regression (2020)

This paper presents a new semi-supervised probabilistic density-based regression approach, called Semi-supervised Weighted Gaussian Regression (SWGR), for the soft sensing of nonlinear and multimode industrial processes given a limited number of labeled data samples. In SWGR, different weights are assigned to each training sample based on their similarities to a query sample. Then a local weighted Gaussian density is built for capturing the joint probability of historical samples around the query sample. The training process of parameters in SWGR incorporates both labeled and unlabeled data samples via a maximum likelihood estimation algorithm. In this way, the soft sensor model is able to approximate the nonlinear mechanics of input and output variables and remedy the insufficiency of labeled samples. At last, the output prediction as well as the uncertainty of prediction can be obtained by the conditional distribution. Two case studies validate that the proposed semi-supervised soft sensing method outperforms some recent methods.
Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor VIIa by Tissue Factor Pathway Inhibitor (TFPI) (2013)

Tissue factor pathway inhibitor (TFPI) is a Kunitz-type protease inhibitor that inhibits activated factor X (FXa) via a slow-tight binding mechanism and tissue factor-activated FVII (TF-FVIIa) via formation of a quaternary FXa-TFPI-TF-FVIIa complex. Inhibition of TFPI enhances coagulation in hemophilia models. Using a library approach, we selected and subsequently optimized peptides that bind TFPI and block its anticoagulant activity. One peptide (termed compound 3), bound with high affinity to the Kunitz-1 (K1) domain of TFPI (Kd ∼1 nM). We solved the crystal structure of this peptide in complex with the K1 of TFPI at 2.55-Å resolution. The structure of compound 3 can be segmented into a N-terminal anchor; an Ω-shaped loop; an intermediate segment; a tight glycine-loop; and a C-terminal α-helix that is anchored to K1 at its reactive center loop and two-stranded β-sheet. The contact surface has an overall hydrophobic character with some charged hot spots. In a model system, compound 3 blocked FXa inhibition by TFPI (EC50 = 11 nM) and inhibition of TF-FVIIa-catalyzed FX activation by TFPI (EC50 = 2 nM). The peptide prevented transition from the loose to the tight FXa-TFPI complex, but did not affect formation of the loose FXa-TFPI complex. The K1 domain of TFPI binds and inhibits FVIIa and the K2 domain similarly inhibits FXa. Because compound 3 binds to K1, our data show that K1 is not only important for FVIIa inhibition but also for FXa inhibition, i.e. for the transition of the loose to the tight FXa-TFPI complex. This mode of action translates into normalization of coagulation of hemophilia plasmas. Compound 3 thus bears potential to prevent bleeding in hemophilia patients.
A new digital voice summing technique for teleconferencing (1984)

The objectives of this paper are to investigate various speech coding techniques to determine their applicability to voice conferencing, to present a new technique for summing directly from the encoded signals, and to demonstrate the audio results and effectiveness of the proposed voice summing technique.
Acoustic signal as an internal standard for quantitation in laser-generated plumes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcoustic signal as an internal standard for quantitation in laser-generated plumesGuoying. Chen and Edward S. YeungCite this: Anal. Chem. 1988, 60, 20, 2258–2263Publication Date (Print):October 15, 1988Publication History Published online1 May 2002Published inissue 15 October 1988https://pubs.acs.org/doi/10.1021/ac00171a020https://doi.org/10.1021/ac00171a020research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Imaging evaluation of the cartilage in rheumatoid arthritis patients with an x-ray phase imaging apparatus based on Talbot-Lau interferometry (2020)

X-ray Talbot-Lau interferometry is one of the x-ray phase imaging methods that has high sensitivity in depicting soft tissues. Unlike earlier x-ray phase imaging methods that required particular types of x-ray sources, such as a synchrotron or a micro-focus x-ray tube, x-ray Talbot-Lau interferometry enables to perform clinical x-ray phase imaging using a conventional x-ray source with a relatively compact configuration. We developed an apparatus to depict cartilage in the metacarpophalangeal joints of the hands. In addition, we examined the apparatus performance by applying it to healthy volunteers and patients with rheumatoid arthritis (RA). Cartilage deformation, which is thought to be a precursor of destruction of the joints, was successfully depicted by the apparatus, suggesting a potential early diagnosis of RA.
The nontoxic tripeptide glycyl-prolyl-glycine amide inhibits the replication of human immunodeficiency virus type 1. (2001)

The tripeptide GPG-NH2 is a nontoxic compound that inhibits the replication of HIV-1 by an apparently new mode of action. Glycyl-prolyl-glycine-NH2 might prove useful by itself or as a lead compound for the treatment of drug-resistant HIV-1. Glycyl-prolyl-glycine-NH2 is currently undergoing phase I/II human clinical trials in Sweden.
Preclinical evaluation of a 15-valent pneumococcal polysaccharide-protein conjugate vaccine in infant rhesus monkeys (52.20) (2010)

Abstract The incidence of invasive pneumococcal disease (IPD) caused by the 91 serotypes of Streptococcus pneumoniae (PN) varies geographically and temporally as a result of changing epidemiology and vaccination. Prevnar® (Pfizer), the first licensed pneumococcal conjugate vaccine (PCV), comprises polysaccharides (PS) from 7 serotypes conjugated to the mutant diphtheria toxin carrier protein, CRM197. In the United States, this vaccine has been highly efficacious in reducing the incidence of IPD caused by vaccine serotypes, however, the incidence of non-vaccine serotypes (e.g., 19A, 22F, and 33F) has increased resulting in the need for vaccines with higher valencies. Indeed, 10- and 13-valent PCVs have recently been licensed. For expanded coverage, we have developed a 15-valent PCV containing PS from serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F and 33F conjugated to CRM197 and formulated on aluminum phosphate adjuvant. The vaccine was tested in infant rhesus monkeys since they, like human infants, do not respond to unconjugated PN PS. Infant (2-3 month old) rhesus monkeys were vaccinated 3 times with PCV-15 or Prevnar® at 2 month intervals, and serotype-specific IgG antibodies were measured using a multiarray electrochemiluminescence (ECL) assay. The results indicate that antibody responses to PCV-15 and Prevnar® were comparable for the 7 common serotypes and that post-vaccination responses to PCV-15 were &gt; 10-fold higher than baseline for the 8 added serotypes.
Performance Analysis in Interference Canceller for Shared Band Satellite Transmission (2019)

This paper presents the performance analysis of the interference canceller with a low-complexity nonlinearity post compensator for shared band satellite transmission, which is proposed in the previous study. The simulation environment is adjusted in accordance with the several parameters, such as the number of the terminal signals, modulation type, and signal-to-noise ratio (SNR). Through the various simulations, we can confirm that the residual error after the interference cancellation at a high SNR disturbs largely the detection of the narrowband signal. In addition, it occurs the error floor in condition of both a high modulation type and a low SNR due to the capability limit of the nonlinearity post compensator. These results can lead to improve the performance of the proposed interference canceller for shared band satellite transmission.
Characterization of a Third Human Thyroid Hormone Receptor Coexpressed with Other Thyroid Hormone Receptors in Several Tissues (1988)

A cDNA that encodes a third type of human thyroid hormone receptor (hTR alpha 1) has been isolated from a skeletal muscle library. The cDNA encodes a 410 amino acid protein, Mr = 46,820. When expressed and translated in vitro, hTR alpha 1 binds T3 with an association constant (ka) of 1.8 x 10(9) M-1. Comparison of the DNA sequence of hTR alpha 1 and a previously identified alpha type thyroid hormone receptor (hTR alpha 2) suggests that they could be transcribed from the same gene, and that alternative RNA splicing results in the synthesis of either hTR alpha 1 or hTR alpha 2. Two mRNA (3.2 kilobases and 6 kilobases) of hTR alpha 1 have been detected in several tissues. At least three types of thyroid hormone receptors (hTR alpha 1, alpha 2, beta), which possess similar affinities for hormone ligands, can be expressed in the same tissue.
DigiLens switchable Bragg grating waveguide optics for augmented reality applications (2018)

DigiLens’s Switchable Bragg Grating (SBG) waveguides enable switchable, tunable and digitally reconfigurable color waveguide displays with a field of view, brightness and form factor surpassing those of competing technologies. DigiLens waveguides can be laminated to integrate multiple optical functions into a thin transparent device. DigiLens waveguide gratings are printed into a proprietary polymer and liquid crystal mixture that can provide any required combination of diffraction efficiency and angular bandwidth in a thin waveguide with high transparency and very low haze. The waveguide combines two key components: an image generation module, essentially a pico projector, and a holographic waveguide for propagating and expanding the image vertically and horizontally. Color is provided by a stack of monochrome waveguides each capable of addressing the entire field of view, incorporating an input rolled K-vector grating, a fold grating, and an output grating. Rolling the K-vectors expands the effective angular bandwidth of the waveguide. Fold gratings enable two-dimensional beam expansion in a single waveguide layer, which translates into lower manufacturing cost, reduced haze, and improved image brightness. The design of these complex SBGs is complicated by their birefringent properties, taking the design of DigiLens waveguides well beyond the frontiers of established ray-tracing codes. Our paper summarizes the key features of DigiLens waveguide technology and discusses our optical design methodology, with examples from DigiLens’s current waveguide HUD products.
Requirement of certain epitope specificities of glycosylation inhibiting factor for the suppression of <i>in vivo</i> IgE and IgG antibody responses (1992)

The ovalbumin (OVA)-specific T cell hybridoma 71B1, which constitutively secretes glycosylation inhibiting factor (GIF) and is specific for the immunogenic epitope represented by amino acids 323-339 in the OVA molecules, failed to form GIF having affinity for nominal antigen upon stimulation with OVA-pulsed antigen-presenting cells (APC). However, the GIF produced by the antigen-stimulated 71B1 cells bound to the mAb 14-12, which is specific for the antigen-binding chain of effector type suppressor T cell factor (TseF), and to mAb specific for TCR. The GIF constitutively released from unstimulated 71B1 cells failed to bind to any of these antibodies. Gel filtration of GIF preparations showed that the 14-12+ GIF from the antigen-stimulated 71B1 cells are composed of 80-100 and 25-35 kDa species, while the GIF from unstimulated cells was 12-15 kDa. Reduction and alkylation treatment of the GIF from the antigen-stimulated cells resulted in the disappearance of the 80-100 and 25-35 kDa GIF, which was accompanied by the formation of the 12-15 kDa GIF. Thus, the GIF from the antigen-stimulated 71B1 cells was similar to the previously described OVA-binding GIF from the 231F1 cells with respect to their antigenic structures and molecular size, and both factors appear to be composed of the 14-12+ polypeptide chain and 12-15 kDa non-specific GIF. However, the GIF from the antigen-stimulated 71B1 cells lacked affinity for the native OVA or synthetic peptide 323-339, and failed to suppress the in vivo antibody response to dinitrophenyl (DNP)-OVA. In contrast, the OVA-binding GIF has affinity for native OVA and the peptide 307-317, to which the cell source of the factor is specific, and suppressed the in vivo anti-hapten antibody response to DNP-OVA. The results suggest that formation of antigen-specific TsF is confined to T cells with certain epitope specificities. It was also found that the OVA-binding GIF failed to suppress the in vivo anti-hapten antibody response to DNP-conjugates of urea-denatured OVA (UD-OVA), which does not bind OVA-binding GIF. However, APC pulsed with UD-OVA appear to express the epitope 307-317 for which the OVA-binding GIF has affinity. The results collectively suggest that the affinity of GIF for an immunizing antigen, rather than processed antigen, is required for immunosuppression.
Abstract 946: Mitochondrial division inhibitor 1 (mdivi-1) overcomes cisplatin resistance independent of dynamin-related protein 1 (Drp1). (2013)

Abstract Platinum based anticancer agents including cisplatin are among the most effective and widely used anticancer drugs. However, the inherent and acquired resistance to these drugs in tumors present significant challenges in cancer treatment and directly lead to treatment failure. We have identified a number of thioquinazolinone derivatives, including the mitochondrial division inhibitor-1 (mdivi-1), that are able to effectively overcome both the inherent and acquired resistance to cisplatin and induce rapid apoptosis in several tumor cell lines. However, the enhanced cellular sensitivity to cisplatin by mdivi-1 was also observed in Drp1 (a mitochondrial fission protein and the supposed target of mdivi-1) knockout MEF cells, indicating Drp1-independent roles of these compounds in overcoming platinum drug resistance. The combination of cisplatin and mdivi-1 induces a robust replication stress response and enhances both intrinsic and extrinsic apoptotic signaling when compared with cisplatin or mdivi-1 treatment alone. Though the combined effect of cisplatin and mdivi-1 is not dependent on mitochondrial fission protein Drp1, mitochondria do play a significant role in the rapid execution of apoptosis triggered by this combination. Highly uncoupled mitochondria, increased generation of reactive oxygen species (ROS) and the release of apoptotic factors were observed only in cells treated with the combination of cisplatin and mdivi-1 and not in cells treated with the compounds individually. Taken together, we have identified novel functions for a set of thioquinazolinone derivatives that are able to overcome platinum drug resistance through enhancing replication stress-mediated apoptotic response. Citation Format: Wei Qian, Vera Roginskaya, Sandra Strychor, Jan Beumer, Lee McDermott, Jingnan Wang, Bennett Van Houten. Mitochondrial division inhibitor 1 (mdivi-1) overcomes cisplatin resistance independent of dynamin-related protein 1 (Drp1). [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 946. doi:10.1158/1538-7445.AM2013-946
Efficient electron-beam-deposited ITO/<i>n</i>-Si solar cells (1979)

Indium tin oxide/silicon heterojunction solar cells with power conversion efficiencies of 10% in AM1 solar spectrum were fabricated. The indium tin oxide (ITO) films were deposited onto n-type silicon by electron-beam evaporation of a mixture of 90 : 10 molar% In2O3 : SnO2 powder. As in SnO2/n-Si cells, the efficiencies of these cells depend upon the angle of incidence of the ITO vapor stream to silicon. We have found the photovoltaic properties of these cells to be very similar to those of SnO2/n-Si devices.
<title>Advances in capillary discharge soft x-ray laser research</title> (2001)

This paper gives an overview of recent soft x-ray laser research at Colorado State University. Progress related to capillary discharge source development includes the observation of emission from the 13.2-nm laser line of Nickel-like Cd in a plasma column generated by a high power capillary discharge. This result suggests it might be possible to extend capillary discharge lasers to significantly shorter wavelengths. In another approach to the generation of coherent soft x-ray radiation we analyzed the possibility of amplifying high order harmonic pulses in a discharge-pumped amplifier. The study of the already well- characterized 46.9-nm Ne-like Ar laser was extended with new spatial coherence and laser wavefront measurements, in work conducted in collaboration with U. California Berkeley and U. of Paris-Sud groups. In the field of applications, we have extended our previous results of plasma interferometry with a tabletop laser to plasma densities up to 0.9 x 10<SUP>21</SUP> cm<SUP>-3</SUP>. Sequences of soft x-ray laser interferograms of plasmas generated by a Nd-YAG laser at intensities between 1 x 10<SUP>11</SUP> W cm<SUP>-2</SUP> and 7 x 10<SUP>12</SUP> W cm<SUP>-2</SUP> show the development and evolution of a concave electron density profile. The detailed mapping of this phenomenon with soft x-ray interferometry exemplifies the usefulness of compact soft x-ray lasers in increasing the understanding of high density plasmas.
Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia (1994)

The chimeric BCR/ABL protein is characteristic of Philadelphia (Ph)+ leukemia because it is the direct product of the Ph translocation and it has been shown to play a causal role in the genesis of leukemia. The BCR/ABL protein exhibits a deregulated tyrosine-kinase activity capable of phosphorylating different cellular substrates in vivo and in vitro. CRKL, an adaptor protein consisting of SH2 and SH3 domains in the absence of a catalytic domain, is one potential in vivo substrate of BCR/ABL. Previous experiments have shown that CRKL is phosphorylated on tyrosine in the chronic myelogenous leukemia (CML) cell line K562 and that CRKL is a substrate for ABL and for BCR/ABL in COS-1 cells. In the current study, we show that in peripheral blood cells a direct correlation exists between the presence of BCR/ABL and the phosphorylation status of CRKL. In Ph- peripheral blood cells, CRKL is present only in the nonphosphorylated form. In contrast, all BCR/ABL+ CML and acute lymphoblastic leukemia patient samples examined showed clear tyrosine-phosphorylation of CRKL. This result strongly suggests that CRKL is a biologically significant substrate for BCR/ABL and is likely to play a major role in the development of Ph+ leukemia.
Deformation Mechanisms in Niobium Silicide-Based Composites (2001)

Abstract : This report describes a 9-month technical effort involving microstructure analysis and modeling of Nb-silicide in-situ composite creep mechanisms. This report will describe both experimental and theoretical modeling of the constitutive creep behavior of Nb-silicide in situ composites. The motivation for this study was to develop an understanding of the creep behavior of a class of materials that possess a long-term high-temperature capability in excess of current nickel-based superalloys. During this program the creep mechanisms that can be enhanced by modification of the microstructure and properties of the metal and silicide phases of the composite have been studied. This investigation has examined the effect of volume fraction of silicide and strength of the metallic phase on the creep performance of the composites. The effect of alloying additions on single-phase and composite creep behavior has also been investigated. This report will describe both experimental and theoretical modeling of the constitutive creep behavior of Nb-silicide in situ composites.
Combination of Chemical Mechanical Polishing and Ultrahigh Vacuum Chemical Vapor Deposition Techniques to Fabricate Polycrystalline Thin Film Transistors (1995)

1995 International Conference on Solid State Devices and Materials,Combination of Chemical Mechanical Polishing and Ultrahigh Vacuum Chemical Vapor Deposition Techniques to Fabricate Polycrystalline Thin Film Transistors
Facile Synthesis of End-Functionalized Regioregular Poly(3-alkylthiophene)s via Modified Grignard Metathesis Reaction (2005)

A simple method for the synthesis of end-functionalized regioregular poly(3-alkylthiophene)s is presented. Using a modified Grignard metathesis (GRIM) reaction, a series of polymers have been synthesized bearing functional groups on one or both ends of the polymer. This method has been demonstrated to work with a variety of different types of Grignard reagents (i.e., aryl, alkyl, allyl, vinyl, etc.). The reactivity of these depends on their nature, where allyl, ethynyl, and vinyl groups produced monofunctionalized polymers, and all others yielded difunctionalized polymers. The end group composition of the polymers was monitored by a combination of MALDI-TOF and 1H NMR and approaches 100% in most cases. By utilizing the proper protecting groups −OH, −CHO, and −NH2 groups have been incorporated onto the polymer ends. The main advantage of this method is that it allows for the in situ functionalization of regioregular polythiophene, generating a variety of end-capped polymers in one step. This approach is advantageous in comparison to previously reported methods because it is not only reliable but also highly versatile and highly efficient.
Purification of NAD-Dependent Mannitol Dehydrogenase from Celery Suspension Cultures (1995)

Mannitol dehydrogenase, a mannitol:mannose 1-oxidoreductase, constitutes the first enzymatic step in the catabolism of mannitol in nonphotosynthetic tissues of celery (Apium graveolens L.). Endogenous regulation on the enzyme activity in response to environmental cues is critical in modulating tissue concentration of mannitol, which, importantly, contribute to stress tolerance of celery. The enzyme was purified to homogeneity from celery suspension cultures grown on D-mannitol as the carbon source. Mannitol dehydrogenase was purified 589-fold to a specific activity of 365 mumol h-1 mg-1 protein with a 37% yield of enzyme activity present in the crude extract. A highly efficient and simple purification protocol was developed involving polyethylene glycol fractionation, diethylaminoethyl-anion-exchange chromatography, and NAD-agarose affinity chromatography using NAD gradient elution. Sodium dodecylsulfate gel electrophoresis of the final preparation revealed a single 40-kD protein. The molecular mass of the native protein was determined to be approximately 43 kD, indicating that the enzyme is a monomer. Polyclonal antibodies raised against the enzyme inhibited enzymatic activity of purified mannitol dehydrogenase. Immunoblots of crude protein extracts from mannitol-grown celery cells and sink tissues of celery, celeriac, and parsley subjected to sodium dodecyl sulfate gel electrophoresis showed a single major immuno-reactive 40-kD protein.