gebhart/patrepeval huggingface dataset:
Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice (2007)

Recurrent haemarthroses in patients with severe haemophilia A often result in irreversible joint damage. Treatment using routine infusions of factor VIII (FVIII) concentrate, a therapy known as prophylaxis, is currently recommended for the prevention of haemarthroses and arthropathy in persons with severe haemophilia A. However, until recently, the body of evidence supporting prophylaxis in comparison with FVIII infusions given only at the time of haemarthroses was mostly retrospective and anecdotal. Recently, two prospective randomized clinical trials have been conducted to compare prophylaxis with on-demand FVIII treatment for the prevention of arthropathy and haemarthroses in young children with haemophilia A. A third prospective, non-randomized trial evaluated a strategy of escalating the dose frequency of prophylaxis. Data from these studies will provide objective evidence for the prevention of haemarthroses and arthropathy in children with severe haemophilia A.
Effects of Ultrasound and Diclofenac Phonophoresis on Inflammatory Pain Relief: Suppression of Inducible Nitric Oxide Synthase in Arthritic Rats (2006)

Ultrasound and phonophoresis treatments probably modulate and prevent the CFA-insult-induced increase in total and regional iNOS-LI neurons. Peripheral use of diclofenac phonophoresis offers little advantage over US alone in affecting the central mechanisms of nociception. The peripheral influences of US and phonophoresis on the central modulation of the spinal nociceptive processing system are important and may reflect the work being done through the neuroplasticity of spinal cord in response to peripheral input of US and phonophoresis.
Low Concentration of Rapamycin Inhibits Hemangioma Endothelial Cell Proliferation, Migration, and Vascular Tumor Formation in Mice (2014)

Rapamycin used in vitro was analogous to low serum concentration rapamycin (7-16 nM) and also significantly inhibited the growth of hemangioma. These results demonstrate a low-toxic drug therapy for hemangioma and encourage continued development of rapamycin and its analogs for use in vascular tumor therapy.
Compact Flip-Chip Interconnection 112-Gbit/s EADFB Laser Array Module With High Eye-Mask Margin (2013)

The first compact and high-performance optical transmitter using flip-chip interconnects has been developed for a 112-Gbit/s transceiver. The flip-chip interconnects provide lower crosstalk and a higher modulation bandwidth than wire interconnects. The flip-chip interconnection module has 3-dB frequency bandwidths of over 30 GHz. This value is up to 5 GHz better than that of a wire interconnection module. Under four-channel simultaneous operation, the OTU4 mask margins for all four lanes of the flip-chip interconnection module exceed 37%. These values are degraded up to only 4% compared with those for single-channel operation. In addition, an error-free transmission through 10 km of single-mode fiber at 112 Gbit/s is demonstrated.
Development of an Intelligent Tire Based Tire - Vehicle State Estimator for Application to Global Chassis Control (2012)

The contact between the tire and the road is the key enabler of vehicle acceleration, deceleration and steering. However, under the circumstances of sudden changes to the road conditions, the driver`s ability to maintain control of the vehicle maybe at risk. In many cases, this requires intervention from the chassis control systems onboard the vehicle. Although these systems perform well in a variety of situations, their performance can be improved if a real-time estimate of the tire-road contact parameters (ranging from kinematic conditions of the tire to its dynamic properties) are available. At the present stage of development, tire-road contact parameters are indirectly estimated using observers based on vehicle dynamics measurements (acceleration, yaw and roll rates, suspension deflections, etc). Although these methods present a relatively accurate solution, they rely heavily on tire and vehicle kinematic formulations and break down in case of abrupt changes in the measured quantities. To address this problem, researchers have been developing certain sensor based advanced tire concepts for direct measurement of the tire-road contact parameters. Thus the new terms "Intelligent Tire" and "Smart Tire", which mean online tire monitoring are thus enjoying increasing popularity among automotive manufacturers and formed the motivation for this thesis to explore the possibility of developing an intelligent tire system. The development of the so called "intelligent tire/ smart tire system" is expected to spur the development of a new generation of vehicle control system with modified control strategies, leveraging information directly coming from the interface between the tire and the road, and in turn significantly reducing the risk of accidents. The specific contributions of this thesis include the following: • Development of an intelligent tire system, with a special attention to development of measurement and sensor feature extraction methodologies of acceleration signals coming from sensors fixed to the tire innerliner • Design of an integrated vehicle state estimator for application to global chassis control • Development of a model-based tire-road friction estimation algorithm • Development of an intelligent tire based adaptive wheel slip controller for anti-lock brake system (ABS) • Development of a piezoelectric vibration energy harvesting system with an adaptive frequency tuning mechanism for intelligent tires
Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents (1980)

8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.
Simple Method to Isolate Mesenchymal Stem Cells from Bone Marrow using Xeno-Free Material: A Preliminary Study (2015)

Attempts to look for FBS substitute showed that platelet rich plasma (PRP) was able to replace fetal bovine serum (FBS), and in some studies even showed better performance than FBS. However, most studies that compared FBS to xeno-free materials such as platelet rich plasma, allogeneic human AB serum, or autologous plasma to culture bone marrow derived stem cells did not conduct the study on primary cultures, as they used passaged cells. Therefore, in this study we used PRP supplemented medium in primary cultures to isolate MSCs from bone marrow without mononuclear cell enrichment step. Processing of bone marrow was done by simple centrifugation at 400g to separate the pellet from supernatant, followed by centrifugation of supernatant to get the remaining stem cells. Both first and second pellets were cultured in 10% PRP containing alpha minimum essential medium (αMEM). The time needed for the cells to attach in the supernatant derived primary culture, time to become confluent and harvested, cell yields in primary culture harvest (pellet and supernatant) were noted. After second centrifugation, supernatant yielded a pellet, and both pellets from first and second centrifugation contained mesenchymal stem cells (MSCs) that can be isolated due to their plastic adherent property. Supernatant derived pellet culture became confluent faster compared to those from first centrifugation. In conclusion: PRP supplemented α MEM can be used to isolate MSCs from bone marrow using simple centrifugation method.
Proposta e verificação de novo método para melhoria de índice de qualidade de segregação de resíduos da construção civil (2020)

A indústria da construção civil é um dos setores da economia que apresenta os maiores índices de geração de resíduos. É de suma importância a correta gestão destes resíduos. Medidas para a avaliação da qualidade desta segregação auxiliam na tomada de decisão do gerador de resíduos. Os poucos métodos de avaliação existentes contam com grande subjetividade. Objetivou-se aprimorar um índice de qualidade de segregação (IQS) já existente em um software de gerenciamento de resíduos da construção civil, denominado Waste Manager (WM), com a proposição de um novo método para avaliar a qualidade da segregação das caçambas para a destinação final. Foram analisados dados do gerenciamento de resíduos de uma obra existentes no software WM e foram feitos levantamentos da real situação das caçambas. O novo método foi proposto adicionando dados de densidade das caçambas e não conformidades observadas. Além disso, este novo método foi aplicado à realidade da obra estudada e os resultados foram comparados ao método já existente. Foi possível concluir que o novo método é mais criterioso, além de representar mais a realidade das caçambas, visto que a avaliação passa a ser menos subjetiva, recomendando-se, portanto, sua aplicação nas obras para a determinação do IQS.
Clinical value of 18F-FDG PET/CT in preoperative diagnosis and TNM staging for breast cancer (2018)

Objective
To investigate the clinical value of 18F-FDG PET/CT in preoperative diagnosis and TNM staging for breast cancer.


Methods
A retrospective study was performed on 75 cases of patients with high likelihood of breast cancer that underwent 18F-FDG PET/CT examination from May 2015 to May 2018.The images were diagnosed and TNM staging was performed by two nuclear medicine physicians with more than five years of relative experience.Statistical software was used to calculate the positive predictive value, negative predictive value, sensitivity, specificity and accuracy, Kappa test was used to assess the consistency between PET/CT and pathological results.


Results
The positive predictive value, negative predictive value, sensitivity, specificity and accuracy of PET/CT diagnosis of breast cancer were 93.5%, 61.5%, 92.1%, 66.7%, and 88.0%, respectively.There was a moderate consistency between PET/CT and pathology results (Kappa=0.568, P<0.05). The correct staging of PET/CT was 49 cases in T stage, with accuracy of 84.5%, 48 cases in N stage, with accuracy of 82.7%, and 57 cases in M stage, with accuracy of 98.3%.


Conclusion
The 18F-FDG PET/CT was a non-invasive evaluation with high clinical value for early diagnosis and TNM staging for breast cancer, especially in detecting lymph node metastasis and distant metastasis.


Key words: 
Breast cancer; TNM staging; PET/CT; 18F-fluorodexoxy glucose; Malignant tumor
A human centered agent-based architecture for electronic brokerage (1999)

Electronic brokerage, envisioning brokers acting on customers' behalf to locate required products and services at the best available price, is a promising technique to solve a specific problem of electronic commerce business relations, i.e. the identification of the goods and services satisfying the user requirements to the highest possible degree. In this paper we describe a electronic brokerage system based on a human-centered layered architecture that allows the broker to proceed seamlessly from the user's vision of the market, based on a nominal scale, to ordinal and interval based representations suitable for intelligent search agents exploiting fuzzy techniques.
Immunoassay and other ligand assays: present status and future trends. (1997)

Immunoassay and other ligand assays have made a major impact on medical research and diagnosis since the first modern (radioisotopically-based) methods emerged. These ubiquitous microanalytic techniques are broadly classifiable as first generation (generally of "competitive" design, e.g., radioimmunoassay), and second generation (generally "noncompetitive," and relying on nonisotopic labels) these (often described as "ultrasensitive") being distinguished by dramatic improvements in sensitivity and performance time. A third generation is now in prospect (based on microarrays of antibody microspots) capable of ultrasensitive determination of hundreds of analytes in a drop of blood. Analogous technology (based on oligonucleotide arrays) is under intensive development for DNA analysis. Array technologies are likely to transform diagnostic medicine in the next decade.
On the implementation of dose‐volume objectives in gradient algorithms for inverse treatment planning (2002)

A method that allows a straightforward implementation of dose-volume constraints in gradient algorithms for inverse treatment planning is presented. The method is consistent with the penalty function approach, which requires the formulation of an objective function with penalty terms proportional to the magnitudes of constraint violations. Dose constraints with respect to minimum and maximum target dose levels are incorporated in quadratic, dose-penalty terms. Analogously, quadratic volume-penalty terms in the objective function reflect the violation of dose-volume constraints imposing limits on the fractions of healthy organ volumes that can be irradiated above specified dose levels. It has been demonstrated that within the framework of this formulation neither modified objective functions nor finite difference gradient calculations are necessary for the incorporation of gradient minimization algorithms. As an example, a simple steepest descent algorithm is presented along with its application to illustrate prostate and lung cases.
Techniques for low-power high-performance ADCs (2014)

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.
Roles of lipopolysaccharide and outer membrane protein OmpC of Escherichia coli K-12 in the receptor function for bacteriophage T4 (1982)

The roles of lipopolysaccharide and OmpC, a major outer membrane protein, in the receptor function for bacteriophage T4 were studied by using Escherichia coli K-12 strains having mutations in the ompC gene or in genes controlling different stages of lipopolysaccharide synthesis. The receptor activity for T4 was monitored by (i) T4 sensitivity of intact cells, (ii) phage inactivation activity of cell envelopes, and (iii) phage inactivation activity of specimens reconstituted from purified OmpC and lipopolysaccharide. It was found that (i) in the presence of the OmpC protein, the essential region of the lipopolysaccharide for the receptor activity was the core-lipid A region that includes the heptose region, whereas the glucose region was not necessarily required for the receptor function; (ii) the OmpC protein was not required at all when the distal end of the lipopolysaccharide was removed to expose a glucose residue at the distal end; and (iii) when cells lacked both the OmpC protein and the glucose region, they became extremely resistant to T4. Based on these findings, the roles of the OmpC protein and lipopolysaccharide in T4 infection are discussed.
Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis (2018)

These findings reveal the roles of the P2RY2 in PDAC metabolic reprogramming, suggesting that P2RY2 might be a potential metabolic therapeutic target for PDAC.
Development of an enzyme‐linked immunoassay for the quantitation of influenza haemagglutinin: an alternative method to single radial immunodiffusion (2012)

We demonstrated the utility of EIA as a suitable alternative to SRID for HA antigen quantitation and stability assessment. This approach would lead to earlier availability of both seasonal and pandemic vaccines, because of the extended cross-reactivity of reagents.
Semantic-aware Grad-GAN for Virtual-to-Real Urban Scene Adaption (2018)

Recent advances in vision tasks (e.g., segmentation) highly depend on the availability of large-scale real-world image annotations obtained by cumbersome human labors. Moreover, the perception performance often drops significantly for new scenarios, due to the poor generalization capability of models trained on limited and biased annotations. In this work, we resort to transfer knowledge from automatically rendered scene annotations in virtual-world to facilitate real-world visual tasks. Although virtual-world annotations can be ideally diverse and unlimited, the discrepant data distributions between virtual and real-world make it challenging for knowledge transferring. We thus propose a novel Semantic-aware Grad-GAN (SG-GAN) to perform virtual-to-real domain adaption with the ability of retaining vital semantic information. Beyond the simple holistic color/texture transformation achieved by prior works, SG-GAN successfully personalizes the appearance adaption for each semantic region in order to preserve their key characteristic for better recognition. It presents two main contributions to traditional GANs: 1) a soft gradient-sensitive objective for keeping semantic boundaries; 2) a semantic-aware discriminator for validating the fidelity of personalized adaptions with respect to each semantic region. Qualitative and quantitative experiments demonstrate the superiority of our SG-GAN in scene adaption over state-of-the-art GANs. Further evaluations on semantic segmentation on Cityscapes show using adapted virtual images by SG-GAN dramatically improves segmentation performance than original virtual data. We release our code at https://github.com/Peilun-Li/SG-GAN.
Effects of the Medicinal Mushroom <i>Agaricus blazei</i> Murill on Immunity, Infection and Cancer (2008)

Agaricus blazei Murill (AbM) is an edible, medicinal mushroom of Brazilian origin. It is used traditionally against a range of diseases, including cancer and chronic hepatitis, and has been cultivated commercially for the health food market. AbM has recently been shown to have strong immunomodulating properties, which has led to increasing scientific interest. In this article, we review current knowledge as to the immunological properties of AbM, and its possible clinical use in connection with infections and cancer. We also present some novel findings, which point to highly different biological potency between AbM extracts of different source and manufacturing.
A Thermal Camera Based Continuous Body Temperature Measurement System (2019)

Body temperature acting an important role in medicine, a number of diseases are characterized by a change in human body temperature. Monitoring body temperature also allows the doctor to track the effectiveness of treatments. But current continuous body temperature measurement (CBTM) system is mainly limited by reaction time, movement noise, and labor requirement. In addition, the traditional contact body temperature measurement has the problem of wasting consumables and causing discomfort. To address above issues, we present a non-contact, automatic CBTM system using a single thermal camera. By applying deep-learning based face detection, object tracking, and calibrated conversion equation, we can successfully extract subject's forehead temperature in real-time. The experimental results show that the overall mean absolute error (MAE) and root-mean-squared-error (RMSE) of our proposed framework compared with industrial instrument are 0.375 °C and 0.439 °C, respectively.
Another Flame Retardant, Tris-(1,3-Dichloro-2-Propyl)-Phosphate, and Its Expected Metabolites Are Mutagens (1978)

A flame retardant used in children's sleepwear, tris-(1,3-dichloro-2-propyl)phosphate (Fyrol FR2) is a mutagen in the Salmonella-mammalian tissue homogenate test after it has been activated by mouse or rat liver homogenate. The expected enzymatic hydrolysis product, 1,3-dichloro-2-propanol, is similarly a mutagen after activation by liver homogenate. A proposed metabolite of the flame retardant, 1,3-dichloro-2-propanone, is a potent mutagen in the absence of such activation. A flame retardant with similar structure, tris-(2,3-dibromopropyl)phosphate (tris-BP), was shown previously to be a mutagen, to cause sterility in animals, to be a carcinogen, and to be absorbed through human skin. These and other flame retardants have characteristic nuclear magnetic resonance spectra that can be used to determine which flame retardant is present in commercially purchased sleepwear. Sleepwear treated with tris-BP, Fyrol FR2, and other chemical additives was being sold in late 1977.
Head-driven phrase structure grammar (1994)

This book presents the most complete exposition of the theory of head-driven phrase structure grammar (HPSG), introduced in the authors' Information-Based Syntax and Semantics. HPSG provides an integration of key ideas from the various disciplines of cognitive science, drawing on results from diverse approaches to syntactic theory, situation semantics, data type theory, and knowledge representation. The result is a conception of grammar as a set of declarative and order-independent constraints, a conception well suited to modelling human language processing. This self-contained volume demonstrates the applicability of the HPSG approach to a wide range of empirical problems, including a number which have occupied center-stage within syntactic theory for well over twenty years: the control of understood subjects, long-distance dependencies conventionally treated in terms of wh-movement, and syntactic constraints on the relationship between various kinds of pronouns and their antecedents. The authors make clear how their approach compares with and improves upon approaches undertaken in other frameworks, including in particular the government-binding theory of Noam Chomsky.
UWB signal sources, antennas and propagation (2004)

This paper discusses the history of ultra-wideband (UWB) wireless and considers spectrum issues. It deals with UWB signal sources, including step, impulse, monocycle and RF pulses. It introduces new NLTL technology which can generate 6 V, 4 ps pulses and which could be used for 10 Gbit/s, millimeter wave, UWB wireless LAN. Several UWB antennas are presented including conical, TEM horn, D*dot, monopole and waveguide horn. Experimental proof is given that UWB free space propagation is not wavelength-dependent.
Study of NH3 Formation and Its Control in the NOx Catalyst System (1976)

NH sub 3 formation was investigated as a function of such feed gas boundary conditions as CO concentration, CO/O sub 2 ratio, space velocity, linear velocity and catalyst bed temperature. Both fresh and aged NOX catalysts were used. Logitudinal patterns of NH sub 3 formation in monolithic NOX catalyst were also determined. Several ideas were tested to reduce NH sub 3 formation in the NOX catalyst through control of feed H sub 2, O sub 2, CO and HC concentrations. Finally, the possibility of extending the optimum A/F range of a NOX catalyst toward leaner A/F ratios by the introduction of methane ahead of the NOX catalyst is discussed. /GMRL/
New Residue Arithmetic Based Barrett Algorithms: Modular Integer Computations (2016)

In this paper, we derive new computational techniques for residue number systems (RNSs)-based Barrett algorithm (BA). The focus of this paper is an algorithm that carries out the entire computation using only modular arithmetic without conversion to large integers via the Chinese remainder theorem. It also avoids the computationally expensive scaling-rounding operation required in the earlier work. There are two parts to this paper. First, we set up a new BA using two constants other than powers of two. Second, an RNS-based BA is described. A complete mathematical framework is described including proofs of the various steps in the computations and the validity of results. Third, we present a computational algorithm for RNS-based BA. Fourth, the RNS-based BA is used as a basis for new RNS-based algorithms for MoM and MoE. The applications we are dealing with are in the area of cryptography.