gebhart/patrepeval huggingface dataset:
Effects of endogenous absorption in human albumin solder for acute laser wound closure (1998)

The combination of 1.32-microm laser light and 50% human albumin solder can be used to create a deep tissue weld resulting in higher acute repair tensile strength. This permits a deep to superficial closure of wounds, which may result in an optimal method of acute closure for full-thickness wounds.
A correlation between cerebrospinal fluid mylein basic protein and anti–myelin basic protein in multiple sclerosis patients (1987)

Free and bound levels of myelin basic protein (MBP) and anti-myelin basic protein (anti-MBP) antibodies were measured by radioimmunoassay in the cerebrospinal fluid of patients with multiple sclerosis who were experiencing acute exacerbations or progressing disease. In a cross-sectional study, free levels of MBP correlated with those of free anti-MBP, and bound MBP levels correlated with those of bound anti-MBP in both groups of patients with active disease. However, acute exacerbations of multiple sclerosis were characterized by higher free MBP and anti-MBP levels with lower levels of bound fractions. Conversely, patients with progressing disease had higher titers of bound than free fractions. Longitudinal studies of individual patients confirmed the association of higher titers of free anti-MBP with acute exacerbations and higher levels of bound anti-MBP with chronic progressing disease.
Polymerization of Methyl Methacrylate Using Dimanganese Decacarbonyl in the Presence of Organohalides (2003)

Dimanganese decacarbonyl (Mn2(CO)10) initiates the radical polymerization of methyl methacrylate (MMA) in the presence of a variety of organic halides including C6H5CH2Br, Me2C(Br)CO2Et, BrCH2C(Br)CH2, and ClCH2C(Cl)CH2 in toluene at 60−90 °C. When using allylic halides (e.g., BrCH2C(Br)CH2 or BrCH2C(CO2Me)CH2), the number-average molecular weights and molecular weight distributions of the PMMA were both low and relatively narrow. The production of relatively low molecular weight polymers when using allylic halides could be explained by an addition-fragmentation chain-transfer mechanism and this is supported by end-group analysis.
Pulsed eddy current: Finding corrosion independently of transducer lift-off (2000)

The pulsed eddy current (PEC) technique holes the potential of becoming the primary means of detecting corrosion in multi-layer structures. However, it is still considered an experimental technique because there are stumbling blocks that must be overcome before it finds acceptance as a field application. In particular, it is necessary to be able to interpret the transient response and distinguish between transducer lift-off, defect locations, and defect size when these effects occur simultaneously. Thus far, most researchers in pulsed eddy currents have not considered lift-off variations in their studies. This parameter is kept constant as it complicates the analysis of pulsed eddy current transient responses. However, lift-off variations will be encountered during field inspections. This paper takes this issue into consideration. Specifically, the paper details an inspection technique which enables the positive identification of corrosion in a multi-layer structure. Moreover, the proposed technique provides a quantitative evaluation of material loss which is independent of lift-off variations.
Synthesis and properties of sulfur dioxide adducts of organophosphinecopper(I) iodides. Structures of the dinuclear compounds tetrakis(methyldiphenylphosphine)di-.mu.-iodo-dicopper(I)-sulfur dioxide and tris(triphenylphosphine)di-.mu.-iodo-dicopper(I) (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and properties of sulfur dioxide adducts of organophosphinecopper(I) iodides. Structures of the dinuclear compounds tetrakis(methyldiphenylphosphine)di-.mu.-iodo-dicopper(I)-sulfur dioxide and tris(triphenylphosphine)di-.mu.-iodo-dicopper(I)P. G. Eller, G. J. Kubas, and R. R. RyanCite this: Inorg. Chem. 1977, 16, 10, 2454–2462Publication Date (Print):October 1, 1977Publication History Published online1 May 2002Published inissue 1 October 1977https://pubs.acs.org/doi/10.1021/ic50176a006https://doi.org/10.1021/ic50176a006research-articleACS PublicationsRequest reuse permissionsArticle Views246Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
An Isotropic 8 (2011)

In this paper, we propose an isotro lens (meta-lens) with an operational frequency imaging applications. The cubic unit cells, comp and capacitor-loaded split rings, are aligned in dimensional lattice. The meta-lens provides an permeability�∆ �a�a�a LF⁄ at 8.5 MHz. The le evanescent fields, producing strong magnetic subwavelength resolution at the image plane. M fabricated meta-lens were found to match full-w
Cloning and Expression in <i>Escherichia coli</i> of the Polysaccharide Depolymerase Associated with Bacteriophage-Infected <i>Erwinia amylovora</i> (1986)

The bacteriophage-encoded polysaccharide depolymerase produced in Erwinia amylovora has been cloned and expressed in Escherichia coli. The bacteriophage ERA103 genome was observed to consist of five EcoRI fragments, labeled as follows: A, 7.5 kilobases (kb); B, 5.0 kb; C, 2.7 kb; D, 2.1 kb; and E, 1.8 kb. A restriction map for ERA103 was also prepared. Each of the fragments were cloned into the positive-selection vector pOP203(A(2)) and pBR322.
Direct C-1 hydroxylation of vitamin D compounds: convenient preparation of 1alpha-hydroxyvitamin D3, 1alpha, 25-dihydroxyvitamin D3, and 1alpha-hydroxyvitamin D2. (1978)

An efficient procedure for the direct C-1 hydroxylation of vitamin D compounds has been developed. The method involves conversion of vitamin D3 tosylates to 3,5-cyclovitamin D derivatives, allylic oxidation with selenium dioxide, and acid-catalyzed solvolysis to the 1 alpha-hydroxyvitamin D analogs. When applied to vitamin D3,25-hydroxyvitamin D3, and vitamin D2, this sequence give the corresponding 1alpha-hydroxylated derivatives in 10-15% yield.
Energy-efficient data representation and routing for wireless sensor networks based on a distributed wavelet compression algorithm (2006)

We address the problem of energy consumption reduction for wireless sensor networks, where each of the sensors has limited power and acquires data that should be transmitted to a central node. The final goal is to have a reconstructed version of the data measurements at the central node, with the sensors spending as little energy as possible, for a given data reconstruction accuracy. In our scenario, sensors in the network have a choice of different coding schemes to achieve varying levels of compression. The compression algorithms considered are based on the lifting factorization of the wavelet transform, and exploit the natural data flow in the network to aggregate data by computing partial wavelet coefficients that are refined as data flows towards the central node. The proposed algorithm operates by first selecting a routing strategy through the network. Then, for each route, an optimal combination of data representation algorithms i.e. assignment at each node, is selected. A simple heuristic is used to determine the data representation technique to use once path merges are taken into consideration. We demonstrate that by optimizing the coding algorithm selection the overall energy consumption can be significantly reduced when compared to the case when data is just quantized and forwarded to the central node. Moreover, the proposed algorithm provides a tool to compare different routing techniques and identify those that are most efficient overall, for given node locations. We evaluate the algorithm using both a second-order autoregressive (AR) model and empirical data from a real wireless sensor network deployment.
A Five-Strain Probiotic Combination Reduces Pathogen Shedding and Alleviates Disease Signs in Pigs Challenged with <i>Salmonella enterica</i> Serovar Typhimurium (2007)

Salmonella spp. infection is a major cause of gastroenteritis, with many thousands of cases reported in the European Union every year. The use of probiotics offers the potential to improve this situation. Here, we investigate the effects of oral treatment of pigs with a defined lactic acid bacteria culture mixture on both clinical and microbiological signs of Salmonella enterica serovar Typhimurium infection. Fifteen weaned pigs blocked by sex and weight were administered control milk or a mixture of five probiotic strains as either a milk fermentate or milk suspension for a total of 30 days. The mixture consisted of two strains of Lactobacillus murinus and one strain each of Lactobacillus salivarius subsp. salivarius, Lactobacillus pentosus, and Pediococcus pentosaceous. Following probiotic administration for 6 days, animals were challenged orally with serovar Typhimurium; the health of the animals and the microbiological composition of their feces were monitored for 23 days postinfection. Animals treated with probiotic showed reduced incidence, severity, and duration of diarrhea. These animals also gained weight at a greater rate than control pigs administered skim milk. Mean fecal numbers of Salmonella were significantly reduced in probiotic-treated animals at 15 days postinfection (P = 0.01). The administered probiotic bacteria improved both the clinical and microbiological outcome of Salmonella infection. These strains offer significant benefit for use in the food industry and may have potential in human applications.
Synthetic wavelength-based phase unwrapping in Fourier domain optical coherence tomography (2009)

Phase-sensitive adjuncts to optical coherence tomography (OCT) including Doppler and polarization-sensitive implementations allow for quantitative depth-resolved measurements of sample structure and dynamics including fluid flows and orientation of birefringent structures. The development of Fourier-domain OCT (FDOCT), particularly spectrometer-based spectral-domain systems with no moving parts (spectral-domain OCT or SDOCT), have greatly enhanced the phase stability of OCT systems particularly when implemented in a common-path geometry. The latter combination has given rise to a new class of nm-scale sensitive quantitative phase microscopies we have termed spectral domain phase microscopy. However, the phase information in all of these techniques suffers from a 2π ambiguity that limits resolvable pathlength differences to less than half the source center wavelength. This is problematic for situations such as cellular imaging, Doppler velocimetry, or polarization sensitive applications where it may be necessary to monitor sample profiles, displacements, phase differences, or refractive index variations which vary rapidly in space or time. A technique previously introduced in phase shifting interferometry uses phase information from multiple wavelengths to overcome this limitation. We show that by appropriate spectral windowing of the broadband light source already used in OCT, particularly by reshaping the source spectrum about two different center wavelengths, the resulting phase variation may be cast in terms of a much longer synthetic wavelength chosen to span the phase variation of interest. We show theoretically that the optimal choice of synthetic wavelength depends upon a tradeoff between the minimum resolvable phase and the length of unambiguous phase measurement. We demonstrate this technique using a broadband source centered at 790 nm by correctly reconstructing the phase profile from a phantom sample containing multiple 2π wrapping artifacts at the center wavelength and compare our result with atomic force microscopy.
Detection of the Human Origin of Blood or Tissue (1989)

This chapter describes the development and validation of monoclonal antibody probes specific to the human protein, albumin, which is a 66,000-dalton molecule present in serum and tissue. The monoclonal antibodies were employed in an enzyme-linked immunosorbent assay (ELISA) capable of detecting nanogram amounts of this protein. The assay was developed under contract from the Federal Bureau of Investigation (FBI) to detect the presence of human albumin in forensic specimens, and thus determine the species of origin of an unknown blood stain. The assay described in this chapter has not been validated on archaeological specimens. The method is described in this volume to acquaint the archaeological community with key concepts and research reagents that may be used in determining the species of origin of unknown, presumptive blood or tissue stains or fragments.
Localized delivery of epidermal growth factor improves the survival of transplanted hepatocytes (1996)

Hepatocyte transplantation may provide a new approach for treating a variety of liver diseases if a sufficient number of the transplanted cells survive over an extended time period. In this report, we describe a technique to deliver growth factors to transplanted hepatocytes to improve their engraftment. Epidermal growth factor (EGF) was incorporated (0.11%) into microspheres (19 ± 12 μm) fabricated from a copolymer of lactic and glycolic acid using a double emulsion technique. The incorporated EGF was steadily released over 1 month in vitro, and it remained biologically active, as determined by its ability to stimulate DNA synthesis, cell division, and long-term survival of cultured hepatocytes. EGF-containing microspheres were mixed with a suspension of hepatocytes, seeded onto porous sponges, and implanted into the mesentery of two groups of Lewis rats. The first group of animals had their portal vein shunted to the inferior vena cava prior to cell transplantation (portal-caval shunt = PCS), and the second group of animals did not (non-PCS). This surgical procedure improves the survival of transplanted hepatocytes. The engraftment of transplanted hepatocytes in PCS animals was increased two-fold by adding EGF microspheres, as compared to adding control microspheres that contained no growth factors. Devices implanted into non-PCS animals had fewer engrafted hepatocytes than devices implanted into PCS animals, regardless of whether blank or EGF-containing microspheres were added. These results first indicate that it is possible to design systems which can alter the microenvironment of transplanted hepatocytes to improve their engraftment. They also suggest that hepatocyte engraftment is not improved by providing single growth factors unless the correct environment (PCS) is provided for the transplanted cells. © 1996 John Wiley & Sons, Inc.
Cylindrical Hall Thrusters (2006)

The cylindrical Hall thruster, proposed and studied at the PPPL features high ionization efficiency, quiet operation, ion acceleration in a large volume-to-surface ratio channel, and performance comparable with the state-of-the-art Hall thrusters. These characteristics were demonstrated in low and medium power ranges. For a miniaturized 100 W cylindrical thruster, we achieved performance improvements, including a 30-40% plume narrowing, reliable discharge initiation, and stable operation in the discharge voltage range of 50-600 V. -
Reflection monitoring method for optical fiber coupler fabrication (1992)

Optical fiber couplers are important devices, both for optical fiber communication systems and fiber-optic sensors. During the fabrication of optical fiber couplers with the fusion elongation method, the splitting ratio should be monitored in order to obtain optical fiber couplers with a desired splitting ratio. In a conventional monitoring method, optical power from two output ends is monitored. In this method, more than two fiber connections are necessary as a preparation, and these connections cause measurement error because of connection loss fluctuation (a typical standard deviation is 0.03 dB).
Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization (2016)

Abstract Therapeutic applications of peptides are currently limited by their proteolytic instability and impermeability to the cell membrane. A general, reversible bicyclization strategy is now reported to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell‐penetrating motif and converted into a conformationally constrained bicyclic structure through the formation of a pair of disulfide bonds. The resulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell‐permeability. Once inside the cell, the disulfide bonds are reduced to produce a linear, biologically active peptide. This strategy was applied to generate a cell‐permeable bicyclic peptidyl inhibitor against the NEMO‐IKK interaction.
Low-polarization-dependence high-efficiency WDM (2003)

A diffraction-grating based demultiplexer is made to have low polarization dependence and high diffraction efficiency properties. The device is made is made of a Si grism working in reflection and having optimised grove profile easily manufactured by standard crystallographic etch of Si surface.
Manipulating image information with pyramids (1985)

Pyramids offer a representation in terms of a set of image primitives of many scales. Insofar as these primitives are appropriate to the basic tasks of image manipulation, pyramids offer a natural format for many operations. For example, in pyramid blending, parts of different images can be combined smoothly, without the artifacts associated with simple mosaic techniques. Smooth transitions are achieved at all scales, with a transition zone that is proportionately smaller as the scale of the image information becomes finer. In another application, multifocusing, one can merge a number of images focused at different depth planes (e.g., from a microscope), and derive a single image that is sharply focused at all depths. This is achieved by selecting the information of maximum local contrast at each position in each image, at each scale. Pyramids can also be used for impletion, the filling in of missing image information. Impletion occurs in natural images in blind spots and also in situations when only sparse information is available. Pyramid based impletion may be useful for image understanding tasks as well as image synthesis tasks.
Oncolytic coxsackievirus therapy as an immunostimulator. (2017)

Recently, the active development of oncolytic virotherapy has gathered attention. Enterovirus research seeks to better understand its pathogenicity. In particular, coxsackievirus A21 (CVA21) is a promising candidate for oncolytic virotherapy, and thus is the focus of many clinical trials. We have reported that coxsackievirus B3 (CVB3) had potent oncolytic activity for cancer, and induced immunogenic cell death of CVB3-infected cells. We then genetically engineered wild type CVB3 and successfully produced a novel recombinant CVB3-miRT, improving its safety by the introducing an organ-specific miRNA target sequence. We also developed the production method of CVB3 agent, and are conducting a clinical trial of CVB3 therapy for cancer patients. In this report, we review recent clinical progress in oncolytic virotherapy of CVA21 and clinical development of our CVB3.
Fabrication of High-resolution Graphene-based Flexible Electronics via Polymer Casting (2019)

In this study, a novel method based on the transfer of graphene patterns from a rigid or flexible substrate onto a polymeric film surface via solvent casting was developed. The method involves the creation of predetermined graphene patterns on the substrate, casting a polymer solution, and directly transferring the graphene patterns from the substrate to the surface of the target polymer film via a peeling-off method. The feature sizes of the graphene patterns on the final film can vary from a few micrometers (as low as 5 µm) to few millimeters range. This process, applied at room temperature, eliminates the need for harsh post-processing techniques and enables creation of conductive graphene circuits (sheet resistance: ~0.2 kΩ/sq) with high stability (stable after 100 bending and 24 h washing cycles) on various polymeric flexible substrates. Moreover, this approach allows precise control of the substrate properties such as composition, biodegradability, 3D microstructure, pore size, porosity and mechanical properties using different film formation techniques. This approach can also be used to fabricate flexible biointerfaces to control stem cell behavior, such as differentiation and alignment. Overall, this promising approach provides a facile and low-cost method for the fabrication of flexible and stretchable electronic circuits.
Server-side encoding, protocol and transport extensibility for remoting systems (2004)

Requirement: Users of remoting systems (e.g., RPC and Messaging) want to concentrate on the data being sent. They should not have to use a different programming model just to use a different protocol.
Clinical outcome following therapeutic vaccination with autologous mRNA electroporated dendritic cell (DC) vaccines in patients with advanced melanoma. (2010)

8547 Background: mRNA electroporated autologous DC are being developed as therapeutic cancer vaccines. Potential advantages include the presentation of all potential tumor antigen confined epitopes by the patient's own HLA-molecules and improved immunostimulatory capacity of the DC-vaccine. Methods: Immature DCs (derived from PBMC obtained by leucapheresis and cultured for 6 days in IL-4/GM-CSF supplemented medium) were electroporated with synthetic mRNA encoding a fusion protein between MAGE-A1, -A3, -C2, Tyrosinase, MelanA/MART-1 or gp100, and DC-LAMP, and poly I:poly C12U or mRNA encoding TLR-4, CD70 and CD40L. DC (12.5 106/antigen) were administered by 4 to 6 ID-injections q2w, and q8w thereafter. Interferon alfa-2b (IFN-a2b, 5 MIU TIW) was initiated at progression, concomitant or following the 4th vaccine in cohort 1, 2, 3, and 4. Results: 70 melanoma pts were recruited between 06/′05 and 06/′09: 44M/26F; med age: 46y (27–75); AJCC stage III: 30, IV-M1a: 8, - M1b: 6, -M1c: 26; WHO-PS 0: 46, 1: 19, 2: 5; serum LDH nl.: 58, -elevated: 12; ulcerated primary: 13, -not ulcerated: 11, -unknown: 46. A total of 466 DC- vaccines were administered (median/pt: 6, range 2-18). Vaccine related AEs: gr 2 local injection site reactions: all pts; gr 2 fever/lethargy: 3 pts; skin depigmentation: 13 pts. Median RFS for pts without evaluable disease (ED): 23 mths (95% CI 12-33); 3 pts have died, mOS has not been reached. The tumor response among 40 pts with ED at baseline: 1 PR and 13 SD (DCR 35%) according to RECIST; 2 CR, 2 PR and 14 SD (DCR 45%) according to immune related response criteria (irRC). PFS > 6 mths was observed for 13 pts with DCR by irRC (median 12 mths, range +7 to +45). Baseline LDH was the only independent prognostic baseline covariable (p < 0.001), and disease control by irRC was the strongest surrogate marker for OS (p < 0.001). Conclusions: Therapeutic vaccination with autologous mRNA electroporated DC combined with IFN-a2b is feasible, safe, and has anti-tumor activity in a subset of patients with advanced melanoma. Stratification by baseline LDH and the use of irRC seems appropriate in future studies with mRNA electroporated DC-vaccines and IFNa-2b. No significant financial relationships to disclose.