gebhart/patrepeval huggingface dataset:
Detection of Antibodies to dsDNA: An Overview of Laboratory Assays (2006)

This brief review is focused on different methodologies available for detection of anti-dsDNA antibodies with respect to the best adequacy between biological results of laboratory and clinical significance. A large array of assays has been developed for the measurement of anti-dsDNA. New assays continually introduced have reflected not only technical innovations to avoid difficulties of some assays, but even more with hope to correlate better with systemic lupus erythematosus (SLE), particularly with its clinical course and exacerbations. Finally, with the development of micro arrays technology new insights into the pathophysiology of autoimmune disease processes should be revealed.
Segregation of HLA genes in multicase narcolepsy families (1998)

In the past 15 years, 411 sporadic narcolepsy patients have been diagnosed in the Hephata Klinik, Schwalmstadt, Germany. They were explored for presence or absence of excessive daytime sleepiness and narcolepsy in their relatives. A subset of 39 patients were explored for presence or absence of parasomnias. Six patients had more than one relative affected by narcolepsy-cataplexy. Forty-seven family members were investigated with the Stanford Center for Narcolepsy Sleep Inventory and a standardized parasomnia questionnaire. Twenty-four relatives had nocturnal polysomnographies and Multiple Sleep Latency Tests. HLA class I typing was performed in all sporadic and familial cases, class II and microsatellite typing was performed in all members of multicase families. Based on the Finnish prevalence study by Hublin et al., 1994, the relative risk for first degree relatives to develop narcolepsy-cataplexy was in our sample 16.5, 34.2 for excessive daytime sleepiness and 426.9 for parasomnias. Cataplexy, excessive daytime sleepiness and single narcoleptic symptoms in the multicase families segregate with the DRBI*1501, CARII:200, CARI: 103, DQBI*0602 haplotype. In two families, members with narcolepsy and isolated symptoms have inherited the DRBI*1501/DQBI*0602 haplotype from the nonaffected parent. The observed segregations in these two families may support the view that narcoleptic symptoms are expressed by DRBI*1501/DQBI*0602 carriers, independent of haplotype origin. Parasomnias do not segregate with a specific haplotype. The frequency of parasomnias in narcolepsy is much higher than in the general population. The empirical risk for first degree family members of narcolepsy patients to develop cataplexy seems to be low, whereas it is higher for EDS and highest for parasomnias.
Usefulness of Left Atrial Emptying Fraction to Predict Ventricular Arrhythmias in Patients With Implantable Cardioverter Defibrillators (2017)

Impaired left atrial emptying fraction (LAEF) is an important predictor of mortality in patients with heart failure. As it may reflect increased LV wall stress, it might predict ventricular arrhythmia (VA) specifically. This study evaluated the predictive value of LAEF assessed with cardiovascular magnetic resonance (CMR) imaging with respect to appropriate device therapy (ADT) for VA and compared its role with CMR assessed scar size and other risk factors. In total, 229 patients (68% male, 63 ± 10 years, 61% ischemic cardiomyopathy) with LV ejection fraction ≤35% who underwent CMR and implantable cardioverter defibrillator (ICD) implantation for primary prevention in 2005 to 2012 were included. CMR was used to quantify LV volumes and function. LV scar size was quantified when late gadolinium enhancement was available (n = 166). Maximum and minimum left atrial volumes and LAEF were calculated using the biplane area-length method. The occurrence of ADT and mortality was assessed during a median follow-up of 3.9 years. Sixty-two patients (27%) received ADT. Univariable Cox analysis showed that male gender, creatinine level, minimum left atrial volume, LAEF, and total scar size were significant predictors of ADT. In multivariable Cox analysis, LAEF (hazard ratio 0.75 per 10%, p <0.01), and scar size (hazard ratio 1.03 per g, p = 0.03) remained the only independent predictors of ADT. Patients with both LAEF > median and scar size < median were at low risk (13% ADT at 5 years), whereas those with LAEF < median and scar size > median experienced 40% ADT at 5 years (log-rank p = 0.01). In conclusion, LAEF independently predicts ADT in patients with primary prevention ICDs. Combined assessment of LAEF and scar size identifies a group with low risk of ADT. Therefore, LAEF assessment could assist in risk stratification for VA to select patients with the highest benefit from ICD implantation.
Thermoreversible Physical Gelation of Block Copolymers in a Selective Solvent (2000)

Solidlike and liquidlike linear viscoelastic responses were observed at low and high temperatures (T) for polystyrene−polyisoprene−polystyrene (SIS) triblock copolymers dissolved in an I-selective solvent, n-tetradecane (C14). These SIS systems behaved as thermoreversible physical gels, with the microphase-separated S domains working as the cross-links at low T. Linear responses of those systems were examined in the vicinity of the sol−gel transition temperature Tgel. For the systems fully equilibrated in an isothermal state at Tgel, the power-law behavior, G‘(ω) ∼ G‘ ‘(ω) ∼ ωn, was observed only at high frequencies ω, and a separate slow relaxation mode was observed at low ω. For the system quenched from high T (>Tgel) to low T (<Tgel), no power-law behavior was found during the transient gelation process. The power-law behavior should have been observed if the system had a self-similar, fractal network structure at Tgel. Thus, the observed lack of this behavior indicated that the structural self-similarity vanished over large length scales, possibly due to dynamic compositional fluctuation of the copolymer chains that dominated slow viscoelastic responses at Tgel (≅TODT). Similar features were observed also for a SI diblock copolymer in C14.
Optimal Shape Design of the S-Shaped Subsonic Intake Using NURBS (2013)

A parallelized design optimization approach is presented for a subsonic S-shaped intake using aerodynamic sensitivity analysis. Two-equation turbulence model is adopted to predict the strong counter vortices in the S-shaped duct more precisely. Sensitivity analysis is performed for the three-dimensional Navier-Stokes equations coupled with two-equation turbulence models using a discrete adjoint method. For code validation, the result of the flow solver is compared with experiment data and bench marking data of other computation researches. To study the influence of turbulence models and grid refinement in the duct flow analysis, the results using several turbulence models are compared with each other on various grid systems. The adjoint variable code is validated by comparison with the complex step derivative results. And to guarantee a sufficient design space, NURBS equations are applied as a new shape function to modify the duct geometry freely. The capability and the efficiency of the present design tools are successfully demonstrated in three-dimensional subsonic inlet flow analysis and design optimization.
WT1 splicing alterations in Wilms' tumors. (2000)

Hereditary and sporadic forms of tumors are generally related to germ-line and somatic mutations of the same tumor suppressor gene. Unexpectedly, in Wilms' tumor, somatic mutations of the WT1 gene were found only occasionally in sporadic cases, although constitutional mutations of this gene are clearly associated with predisposition. It has been suggested that abnormal splicing may be another mode of somatic WT1 alteration. However, this idea was based on the analysis of a small series of tumors, precluding accurate evaluation of the frequency of such changes. To investigate WT1 changes at the somatic level in more detail, we analyzed the levels of the four isoform transcripts produced by alternative splicing events in a large series of 50 tumors, normal mature kidneys, and fetal kidneys. We characterized splicing alterations in 63% of sporadic Wilms' tumors. Moreover, taking into account the decreased and increased overall levels of WT1 mRNA, the percentage of sporadic tumors with changes in WT1 expression reached 90%. Whether and how these alterations of expression play a role in the tumorigenic process remain to be evaluated.
Enhanced distributed streaming system based on RTP/RTSP in resurgent ability (2005)

In this paper, we propose the redirect streaming service model to enhance resurgent ability. The system consists of a redirect server, local streaming servers and clients. Redirect server searches the best streaming serve and streaming servers starts a requested service or resumes it when in a trouble. RTSP/RTP is one of the effective solutions to improve QoS in VOD, however a service can be broken off by an overloaded server or network especially in live. We designed and implemented not only a distributed streaming system that solves the broken-off service to enhance a resurgent system, but also DSSP, distributed streaming service protocol.
Ministrokes in Rat Barrel Cortex (1995)

This model of local ischemia, produced deliberately in the functionally defined barrel cortex in rats, leads to ministrokes. Changes can be followed by videomicroscopy as they develop, and processes of recovery can potentially be monitored. Infarcts are confirmed by histology for their location and extent in the somatic representation.
Anatomy and Osteotomy of the Greater Trochanter (1979)

Eleven human cadaver hips were dissected to define exactly the musculofascial anatomy of the greater trochanter and the supportive structures around it. A readily identifiable plane was defined that permitted osteotomy of the greater trochanter from an anterior approach leaving the vastus lateralis attached to it so that the trochanter could be folded posteriorly and then replaced securely. The osteotomy has been used in difficult total hip replacements at Waterbury (Conn) Hospital and found to be very satisfactory with no wire or bolt fixation necessary to maintain trochanter stability after surgery. Until a large series of these osteotomies has been reviewed, however, additional fixation may be advisable.
Transmission of classically entangled beams through mouse brain tissue (2018)

Light transmission of Laguerre-Gaussian vector vortex beams in different local regions in mouse brain tissue is investigated. Transmittance is measured in the ballistic and diffusive regions with various polarizations states and orbital angular momentums (OAM). The transmission change observed with structured light other than linear polarization is attributed to chiroptical phenomena from the chiral brain media and the handedness of the light. For instance, classically entangled beams showed higher transmittance and constant value dependency on OAM modes than linear modes did. Also, circular polarization beam transmittance showed strong increase with topical charge OAM ( ℓ), which could be attributed to chiroptical effect.
Nanometer-accurate grating fabrication with scanning beam interference lithography (2002)

We are developing a Scanning Beam Interference Lithography (SBIL) system. SBIL represents a new paradigm in semiconductor metrology, capable of patterning large-area linear gratings and grids with nanometer overall phase accuracy. Realizing our accuracy goal is a major challenge because the interference fringes have to be locked to a moving substrate with nanometer spatial phase errors while the period of the fringes has to be stabilized to approximately one part per million. In this paper, we present a review of the SBIL design, and report recent progress towards prototyping the first-ever SBIL tool.
Ternary Linear Codes with Few Weights from Functions with Two Variables (2017)

How to construct good linear codes is an important problem in coding theory. This paper considers the construction of linear codes from functions with two variables, presents a class of two-weight and three-weight ternary linear codes and employs the Gauss sums and exponential sums to determine the parameters and weight distribution of these codes. Linear codes with few weights have applications in consumer electronics, communication and date storage systems. Linear codes with two weights have applications in strongly regular graphs and linear codes with three weights can be applied in association schemes.
Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila. (1988)

Two genes known to control the determination of segmental identity in Drosophila melanogaster are polycomb and antennapedia. To identify additional genes involved in the determination of segmental identity, we have isolated dominant modifers (both suppressors and enhancers) of polycomb and/or antennapedia mutations. Sixty-four such modifier mutations have been recovered and mapped to 18 complementation groups. All of the mutations identify genes necessary for viability of the zygote. Six of the 18 genes that were identified by mutations that interact with polycomb and/or antennapedia have been previously characterized as homoeotic genes [i.e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes.
Enhancement of Cellulose Degradation by Cattle Saliva (2015)

Saccharification of cellulose is a promising technique for producing alternative source of energy. However, the efficiency of conversion of cellulose into soluble sugar using any currently available methodology is too low for industrial application. Many additives, such as surfactants, have been shown to enhance the efficiency of cellulose-to-sugar conversion. In this study, we have examined first whether cattle saliva, as an additive, would enhance the cellulase-catalyzed hydrolysis of cellulose, and subsequently elucidated the mechanism by which cattle saliva enhanced this conversion. Although cattle saliva, by itself, did not degrade cellulose, it enhanced the cellulase-catalyzed degradation of cellulose. Thus, the amount of reducing sugar produced increased approximately 2.9-fold by the addition of cattle saliva. We also found that non-enzymatic proteins, which were present in cattle saliva, were responsible for causing the enhancement effect. Third, the mechanism of cattle saliva mediated enhancement of cellulase activity was probably similar to that of the canonical surfactants. Cattle saliva is available in large amounts easily and cheaply, and it can be used without further purification. Thus, cattle saliva could be a promising additive for efficient saccharification of cellulose on an industrial scale.
Use of Lactobacillus rhamnosus (ATCC 53103) as Whole-Cell Biocatalyst for the Regio- and Stereoselective Hydration of Oleic, Linoleic, and Linolenic Acid (2018)

Natural hydroxy fatty acids are relevant starting materials for the production of a number of industrial fine chemicals, such as different high-value flavour ingredients. Only a few of the latter hydroxy acid derivatives are available on a large scale. Therefore, their preparation by microbial hydration of unsaturated fatty acids, affordable from vegetable oils, is a new biotechnological challenge. In this study, we describe the use of the probiotic bacterium Lactobacillus rhamnosus (ATCC 53103) as whole-cell biocatalyst for the hydration of the most common unsaturated octadecanoic acids, namely oleic acid, linoleic acid, and linolenic acid. We discovered that the addition of the latter fatty acids to an anaerobic colture of the latter strain, during the early stage of its exponential growth, allows the production of the corresponding mono-hydroxy derivatives. In these experimental conditions, the hydration reaction proceeds with high regio- and stereoselectivity. Only 10-hydroxy derivatives were formed and the resulting (R)-10-hydroxystearic acid, (S)-(12Z)-10-hydroxy-octadecenoic acid, and (S)-(12Z,15Z)-10-hydroxy-octadecadienoic acid were obtained in very high enantiomeric purity (ee > 95%). Although overall conversions usually do not exceed 50% yield, our biotransformation protocol is stereoselective, scalable, and holds preparative significance.
Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis (2018)

Central to the recognition, signaling, and repair of DNA double-strand breaks (DSBs) are the MRE11-RAD50-NBS1 (MRN) complex and mediator of DNA damage checkpoint protein 1 (MDC1), the interplay of which is essential for initiation and amplification of the DNA damage response (DDR). The intrinsic rule governing the regulation of the function of this molecular machinery remains to be investigated. We report here that the ubiquitin-specific protease USP7 was physically associated with the MRN-MDC1 complex and that the MRN-MDC1 complex acted as a platform for USP7 to efficiently deubiquitinate and stabilize MDC1, thereby sustaining the DDR. Accordingly, depletion of USP7 impaired the engagement of the MRN-MDC1 complex and the consequent recruitment of the downstream factors p53-binding protein 1 (53BP1) and breast cancer protein 1 (BRCA1) at DNA lesions. Significantly, USP7 was overexpressed in cervical cancer, and the level of its expression positively correlated with that of MDC1 and worse survival rates for patients with cervical cancer. We demonstrate that USP7-mediated MDC1 stabilization promoted cervical cancer cell survival and conferred cellular resistance to genotoxic insults. Together, our study reveals a role for USP7 in regulating the function of the MRN-MDC1 complex and activity of the DDR, supporting the pursuit of USP7 as a potential therapeutic target for MDC1-proficient cancers.
Circular Tomosynthesis: Potential in Imaging of Breast and Upper Cervical Spine—Preliminary Phantom and in Vitro Study (2003)

Phantom and in vitro studies were performed to evaluate the potential application of digital circular tomosynthesis in imaging of the breast and upper cervical spine. A prototype volumetric x-ray system was used to image a mammographic phantom, a fresh mastectomy specimen, and a head phantom containing the upper cervical spine. Results show that breast tissue visualization is improved by the ability to produce sectional images that blur overlying structures and yield three-dimensional information about calcification clusters. In upper cervical spine imaging, digital circular tomosynthesis effectively blurs overlying jaw and skull structures so that C1 and C2 can be visualized in a standard anteroposterior view.
Challenges and Opportunities of IT in Indian Agriculture Sustainability (2021)

Agriculture is the sole greatest main and significant living sector for masses in India. International Food Policy Research Institute (IFPRI) unconfined report on Global Hunger. According to that report India has expatriate from preceding 97th place to 100 in 2017 and the value is 31.4 shows the place of our country originate in serious category. The neighbor countries Nepal, and Sri Lanka are better in hunger score. In direction to have constant expansion in Indian sustainable agriculture is a primary requirement. Forthcoming of Indian agriculture seriously depends on the current circumstances of agriculture and trends of various indicator.
How to cite this article:
Patel A, Prajapati S. Challenges and Opportunities of IT in Indian Agriculture Sustainability. J Adv Res Embed Sys 2020; 7(2): 19-22.
Characterization and translation of transmissible gastroenteritis virus mRNAs (1986)

Three protein species were identified in purified transmissible gastroenteritis virus particles (strain Purdue). They are thought to represent constituents of the peplomer (E2; molecular weights of 280,000 and 240,000), the envelope (E1; molecular weights of 28,000, 31,500, and 33,000), and the nucleocapsid (N; molecular weight of 48,000). In infected cells, proteins with molecular weights of 195,000 (E2), 48,000 (N), and 28,000 (E1) were detected. Tunicamycin, an inhibitor of N glycosylation, prevented the appearance of polypeptides with molecular weights of 195,000 and 28,000 in infected cells; instead, proteins with molecular weights of 160,000 and 25,000 were observed. One minor and five major mRNA species were detected in porcine cells after infection. Their size was determined to be 23.6 kilobases (kb) (RNA1), 8.4 kb (RNA3), 3.8 kb (RNA4), 3.0 kb (RNA5), 2.6 kb (RNA6), and 1.9 kb (RNA7). The RNAs were translated in vitro. RNA7 was shown to code for the N protein. Although complete separation of RNA6 could not be achieved, it was shown to encode an unglycosylated (molecular weight of 25,000) precursor of E1 (molecular weight of 28,000). RNA4 was translated into a nonstructural protein with a molecular weight of 24,000. Translation of RNA3 resulted in proteins with molecular weights of 250,000 and 130,000 and smaller molecules which could be precipitated with a monoclonal antibody directed against E2.
Dry Mortars (2003)

The article contains sections titled: 1. Introduction 2. Development 2.1. Historical and Technical Development 2.2. Advantages of Dry-Mix Mortars 3. Composition 3.1. Binders 3.1.1. Mineral Binders 3.1.2. Organic Binders 3.2. Aggregates 3.3. Additives 3.3.1. Cellulose Ethers 3.3.2. Other Additives 4. Production 5. Testing 6. Applications 6.1. Brick-Laying Mortars and Related Adhesives 6.2. Renders and Plasters 6.3. Tile Adhesives 6.4. Tile Grouts 6.5. Exterior Thermal Insulation Composite Systems 6.6. Powder Paints 6.7. Cementitious Waterproofing Sealing Slurries 6.8. Self-Leveling Underlayments and Screeds 6.9. Patching and Repair Mortars 7. Market Aspects
Mobility Support and Operation of Information Centric Networking Approach (2018)

Recent development in mobile technology makes data traffic intensifies, due to the vast devices connectivity. Also, increases the needs for efficient and scalable distribution of data and services over the Internet. Therefore, the Information Centric Networking paradigm was proposed, with different approaches as a clean-slate redesign of current host-centric Internet architecture. It evolved to access data independent from its location, by replacing IP addresses with content named. This paper reviews the most popular Information Centric Networking approaches, review and summarizes some of its features, such as naming, routing, caching and mobility in tabular form. In addition, the modes of operations based on named resolution services and named based routing for the approaches with some network exemplary diagrams were presented. Also, mobility supports for consumer, and mobility challenges from current to feature Internet were discussed for future research.