gebhart/patrepeval huggingface dataset:
Ecarin Clotting Time is Sensitive to Heparinoids: Comparison of Two Different Techniques (2001)

Ecarin clotting time (ECT) is currently developed for the specific monitoring of antithrombin drugs, such as hirudin, argatroban, and hirulog. Aqueous reagent and dry chemistry technology have become available for ECT monitoring of antithrombin agents. Currently, many heparinoids and heparinomimetic drugs are being developed. These agents activate heparin cofactor II (HCII) and primarily mediate their effects by inhibiting thrombin. Although the test is specific for antithrombin agents, heparin cofactor II-mediated thrombin inhibitors are capable of prolonging the ECT. In order to study the relative effects of some of these agents, ECT was measured in human plasma supplemented with Pl-88 (a sulfated pentomanose; Progen Industries Limited, Sydney, Australia), aprosulate, pentosan polysulfate, dermatan sulfate, unfractionated heparin (UFH), and recombinant hirudin (r-hirudin). All agents were supplemented to the citrated-pooled plasma prepared from 10 healthy volunteers at a graded dosage of 0 to 100 microg/ml. These techniques gave comparable results for all of the agents used (PI-88, r2 = 0.99; r-hirudin, r2 = 0.98; UFH, r2 = 0.98; dermatan sulfate, r2 = 0.95; aprosulate, r2 = 0.95; pentosan polysulfate, r2 = 0.94). The relative anticoagulant effects of various agents used on ECT varied widely, exhibiting their potency in the following order: r-hirudin = pentosan polysulfate > dermatan sulfate > PI-88 > aprosulate > UFH. The sensitivity of ECT was adjusted by varying the concentration of the ecarin reagent. The results suggest that HCII-mediated inhibition of thrombin can be detected by using ECT reagents.
Attonewton force detection using microspheres in a dual-beam optical trap in high vacuum (2015)

We describe the implementation of laser-cooled silica microspheres as force sensors in a dual-beam optical dipole trap in high vacuum. Using this system we have demonstrated trap lifetimes exceeding several days, attonewton force detection capability, and wide tunability in trapping and cooling parameters. Measurements have been performed with charged and neutral beads to calibrate the sensitivity of the detector. This work establishes the suitability of dual-beam optical dipole traps for precision force measurement in high vacuum with long averaging times, and enables future applications including the study of gravitational inverse square law violations at short range, Casimir forces, acceleration sensing, and quantum optomechanics.
A Compact Gate Control and Voltage-Balancing Circuit for Series-Connected SiC MOSFETs and Its Application in a DC Breaker (2017)

This paper presents a novel compact circuit combining function of gate control and voltage balancing for series-connected silicon carbide (SiC) metal-oxide-semiconductor field-effect transistor (MOSFET). Two series-connected SiC MOSFETs with the proposed circuit only require a single standard gate driver to achieve the gate control and voltage balancing during both steady-state and switching transition. Moreover, the proposed circuit is only composed of ten passive components. Therefore, the proposed circuit provides a low-cost and highly reliable method to increase the blocking voltage of the SiC MOSFET. The operation principles of the proposed circuit are theoretically analyzed. In addition, the high-blocking-voltage device is not only required in switching-mode power supply (SMPS) but also in dc-breaker applications. The proposed circuit is then modified to make it suitable to the dc-breaker applications. The simulation and experimental results validate the effectiveness and superiority of the proposed circuit in both SMPS and dc-breaker applications.
Use of BIER IPv6 Encapsulation (BIERv6) for Multicast VPN in IPv6 networks (2020)

This draft defines the procedures and messages for using Bit Index
Explicit Replication (BIER) for Multicast VPN Services in IPv6
networks using the BIER IPv6 encapsulation. It provides a migration
path for Multicast VPN service using BIER MPLS encapsulation in MPLS
networks to multicast VPN service using BIER IPv6 encapsulation
(BIERv6) in IPv6 networks.
Coupling coefficient improvement for inductor coupled vertical interconnect in 3D IC die stacking (2009)

We proposed a vertical magnetic coupled interconnect design procedure for 3D IC stacking. As the interconnect is modeled as a coupled inductor pair, we can convert it into a bandpass filter by adding series and shunt capacitors. With given center frequency and bandwidth of the bandpass filter, the required self and mutual inductance in magnetic coupled interconnect and serial and parallel capacitance can be calculated quickly. In our design using TSMC 0.18µm CMOS process, the addition of capacitors increased the transmission coefficient by 7dB. The size of loops for magnetic coupled interconnect is 200µm, the communication distance is 30µm. By using an ASK modulation scheme, we can up-covert the baseband signal spectrum to the lower loss passband of the filter. Our bandpass interconnect can achieve 3.5 Gbps data rate and 6.77pJ/bit power consumption.
Effect of schedule on activity and toxicity of 5-azacytidine in acute leukemia: A southwest oncology group study (1981)

One-hundred-fifty-four patients with acute leukemia and extensive prior chemotherapy were treated with 5-Azacytidine and evaluated according to five different schedules. One-hundred-twenty patients received adequate trials; 34 patients died within 14 days of onset of treatment. Nine patients achieved a complete remission (CR) and two achieved a partial remission. Although two of the treatments have a higher remission rate, the data were not statistically significant. The median time to CR was 48 days (range 21-173). The median duration of CR was 65 days (range 39-369). There was no difference in response rate according to cell type. The median age of responders was 31 years, and 39 years for nonresponders. Proportionately there were more women among responders (5M/6F) and more men (70M/39F) among nonresponders. At onset of therapy the median leukocyte counts were similar between responding (5.4 X 10(3)) and nonresponding (5.7 X 10(3)) patients, but the proportion of leukemic cells was significantly higher among nonresponding patients (46% vs. 7%). Toxicities included nausea, vomiting, diarrhea, skin rash, myalgias, prolonged myelosuppression, hypotension, and central nervous system stupor and/or coma. Lower dose continuous infusion schedules of five-, seven-, and ten-days duration appear effective and were associated with less toxicity.
SRVM (2016)

Single-Root I/O Virtualization (SR-IOV) is a specification that allows a single PCI Express (PCIe) device (ysical function or PF) to be used as multiple PCIe devices (virtual functions or VF). In a virtualization system, each VF can be directly assigned to a virtual machine (VM) in passthrough mode to significantly improve the network performance. However, VF passthrough mode is not compatible with live migration, which is an essential capability that enables many advanced virtualization features such as high availability and resource provisioning. To solve this problem, we design SRVM which provides hypervisor support to ensure the VF device can be correctly used by the migrated VM and the applications. SRVM is implemented in the hypervisor without modification in guest operating systems or guest VM drivers. Our experimental results show that SRVM can effectively migrate all memory state, and there is no data loss or corruption in applications after live migration. SRVM does not increase VM downtime. It only costs limited resources (an extra CPU core), and there is no significant runtime overhead in VM network performance. In fact, since the VF can continue to be used during the pre-copy ase, it offers network throughput which is 9.6 times and network latency which is 98% lower compared to other solutions that switch to para-virtualization mode during live migration.
Aging characteristics of II–VI yellow light emitting diodes with beryllium chalcogenide (BeZnSeTe) active layers on InP substrates (2004)

Aging characteristics of BeZnSeTe II–VI yellow light emitting diodes (LEDs) fabricated on InP substrates by molecuar beam epitaxy were investigated under higher current injections from 130 to 900 A/cm2 at room temperature. Light output decays during the aging are approximated using the decay model based on the carrier-recombination enhanced defect motion. Half lifetimes estimated from the approximations are compared with the literature data of ZnCdSe/MgZnSSe LEDs, which clearly indicates quite long lifetimes of the BeZnSeTe LEDs. In fact a long lifetime more than 2500 h was obtained at the injection current density of 130 A/cm2 with no gradual decay except for the slight initial decay. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Energy-efficient virtual network embedding in networks for cloud computing (2017)

Cloud computing is based on several service models such as Network as a Service (NaaS), Software as a Service (SaaS), Platform as a Service (PaaS), and Infrastructure as a Service (IaaS). NaaS is a business model that aims to provide virtual network (VN) services over the internet from shared cloud data centres. Virtual network embedding (VNE) is one of the core technologies in NaaS resource allocation. In view of the enormous energy consumption by numerous cloud data centres, energy-efficient VNE becomes a new research focus. In this paper, we propose an energy efficient virtual network embedding (EEVNE) approach for cloud computing networks, in which power savings are introduced by consolidating resources in the network and data centres. EEVNE is based on the evaluation of the energy consumption by hosts, the allocation of virtual resources both in nodes and links, as well as the cost and revenue in network virtualisation. We also formulated a heuristic embedding algorithm based on Group Search Optimiser (GSOVNE) to solve the NP-hard problem. Furthermore, a reconfiguration algorithm is developed to improve the utility of fragmented resources. Simulation experiments show that the proposed algorithm can effectively increase VN acceptance ratio and reduce energy consumption when large quantities of virtual networks arrive and depart over time.
Effect of <i>E. coli Nissle</i> 1917 on post‐inflammatory visceral sensory function in a rat model (2005)

The EcN administration caused a significant reduction of VH. Whether EcN might play a role in the treatment of post-infectious functional bowel disorders remains to be investigated in further studies.
Transaural experiments and a revised duplex theory for the localization of low-frequency tones (2016)

The roles of interaural time difference (ITD) and interaural level difference (ILD) were studied in free-field source localization experiments for sine tones of low frequency (250-750 Hz). Experiments combined real-source trials with virtual trials created through transaural synthesis based on real-time ear canal measurements. Experiments showed the following: (1) The naturally occurring ILD is physically large enough to exert an influence on sound localization well below 1000 Hz. (2) An ILD having the same sign as the ITD modestly enhances the perceived azimuth of tones for all values of the ITD, and it eliminates left-right confusions that otherwise occur when the interaural phase difference (IPD) passes 180°. (3) Increasing the ILD to large, implausible values can decrease the perceived laterality while also increasing front-back confusions. (4) Tone localization is more directly related to the ITD than to the IPD. (5) An ILD having a sign opposite to the ITD promotes a slipped-cycle ITD, sometimes with dramatic effects on localization. Because the role of the ITD itself is altered by the ILD, the duplex processing of ITD and ILD reflects more than mere trading; the effect of the ITD can be reversed in sign.
The Future of Cell Transplant Therapies: A Need for Tissue Grafting (2010)

Current methodologies of solid organ-derived cell transplant therapies introduce donor cells into hosts through a vascular route, a strategy modeled after hematopoietic therapies. These strategies fail because of inefficient engraftment, poor survival of the cells, and propensity for formation of life-threatening emboli. Transplant success necessitates grafting methods, requiring a mixture of appropriate cell sources embedded into or onto precise mixes of extracellular matrix components and then localized to the diseased or dysfunctional tissue, promoting necessary proliferation, engraftment, and vascularization. Grafting technologies are rapidly translatable to therapeutic uses in patients and provide alternative treatments for regenerative medicine.
A new synthesis of the F5 furan fatty acid and a first synthesis of the F6 furan fatty acid (2008)

Total syntheses have been achieved of the two furan fatty acids F 5 and F 6 1, in which the central step features generation of the furan ring using either iodine or silver-induced 5-endo-dig cyclisations of suitably functionalized 3-alkyne-1,2-diols.
Data fusion‐based assessment of raw materials in mammalian cell culture (2012)

In mammalian cell culture producing therapeutic proteins, one of the important challenges is the use of several complex raw materials whose compositional variability is relatively high and their influences on cell culture is poorly understood. Under these circumstances, application of spectroscopic techniques combined with chemometrics can provide fast, simple, and non-destructive ways to evaluate raw material quality, leading to more consistent cell culture performance. In this study, a comprehensive data fusion strategy of combining multiple spectroscopic techniques is investigated for the prediction of raw material quality in mammalian cell culture. To achieve this purpose, four different spectroscopic techniques of near-infrared, Raman, 2D fluorescence, and X-ray fluorescence spectra were employed for comprehensive characterization of soy hydrolysates which are commonly used as supplements in culture media. First, the different spectra were compared separately in terms of their prediction capability. Then, ensemble partial least squares (EPLS) was further employed by combining all of these spectral datasets in order to produce a more accurate estimation of raw material properties, and compared with other data fusion techniques. The results showed that data fusion models based on EPLS always exhibit best prediction accuracy among all the models including individual spectroscopic methods, demonstrating the synergetic effects of data fusion in characterizing the raw material quality.
FOREST CONSERVATION & ENVIRONMENT (2023)

Planting and maintaining forests for the benefit of present and future generations is known as forest conservation. A rapid adjustment in the mix of tree species and the age distribution is another goal of forest preservation efforts. The term "forest conservation" refers to the practice of protecting forests in order to preserve the many valuable resources they contain. Forests are essential to human survival because they provide a wide variety of resources, including carbon storage and acting as a carbon sink, oxygen production (for which all life on Earth is dependent), purification of water, habitat for wildlife (forests are home to half of all species), mitigation of global warming, absorption of toxic gases and noise, conservation of soil, and prevention of natural disasters. However, modern human activities pose the greatest and most immediate threat to forests, including the expansion of agriculture, timber plantations, and other land uses (such as pulp and paper plantations, urbanization, road building, and industrialization). Therefore, raising public awareness is essential. This paper provides a variety of methods for protecting forests and raising public awareness, both of which are crucial to sustaining a healthy ecosystem. This is a national initiative, and we must participate. Keywords : Solutions, awareness, importance of conservation, Forest conservation
Effects of composition on the formation temperatures and electrical resistivities of C54 titanium germanosilicide in Ti–Si1−xGex systems (1999)

The effects of alloy composition on the formation temperature and electrical resistivities of C54 titanium germanosilicide formed during the Ti/Si1−xGex (x=0, 0.3, 0.4, 0.7, 1) solid state reaction have been investigated. Ti5(Si1−yGey)3, C49– and C54–Ti(Si1−zGez)2 were observed to form in the Ti/Si1−xGex (x⩾0.4) systems. On the other hand, Ti6(Si1−yGey)5 and C54–Ti(Si1−zGez)2 were found in the Ti/Si1−xGex (x≧0.7) systems. For both cases, the relationship of x&gt;y&gt;z was found. The appearance and agglomeration temperature of low-resistivity C54–Ti(Si1−zGez)2 were both found to decrease with the Ge concentration. The resistivities of C54–Ti(Si1−zGez)2 were measured to be 15–20 μΩ/cm. The segregation of Si1−wGew (w&gt;x) was found in all samples annealed above 800 °C. The effects of thermodynamic driving force, kinetic factor, and composition of the micro-area are discussed.
Models for the reduced states of cytochrome P-450 and chloroperoxidase. Structures of a pentacoordinate high-spin iron(II) mercaptide mesoporphyrin derivative and its carbonyl adduct (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModels for the reduced states of cytochrome P-450 and chloroperoxidase. Structures of a pentacoordinate high-spin iron(II) mercaptide mesoporphyrin derivative and its carbonyl adductChristine Caron, Andre Mitschler, Georges Riviere, Louis Ricard, Michel Schappacher, and Raymond WeissCite this: J. Am. Chem. Soc. 1979, 101, 24, 7401–7402Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/ja00518a047https://doi.org/10.1021/ja00518a047research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism (2015)

E3 ligases are genetically implicated in many human diseases, yet E3 enzyme mechanisms are not fully understood, and there is a strong need for pharmacological probes of E3s. We report the discovery that the HECT E3 Nedd4-1 is a processive enzyme and that disruption of its processivity by biochemical mutations or small molecules switches Nedd4-1 from a processive to a distributive mechanism of polyubiquitin chain synthesis. Furthermore, we discovered and structurally characterized the first covalent inhibitor of Nedd4-1, which switches Nedd4-1 from a processive to a distributive mechanism. To visualize the binding mode of the Nedd4-1 inhibitor, we used X-ray crystallography and solved the first structure of a Nedd4-1 family ligase bound to an inhibitor. Importantly, our study shows that processive Nedd4-1, but not the distributive Nedd4-1:inhibitor complex, is able to synthesize polyubiquitin chains on the substrate in the presence of the deubiquitinating enzyme USP8. Therefore, inhibition of E3 ligase processivity is a viable strategy to design E3 inhibitors. Our study provides fundamental insights into the HECT E3 mechanism and uncovers a novel class of HECT E3 inhibitors.
Feasibility of Heart Rate Variability Measurement from Quadrature Doppler Radar Using Arctangent Demodulation with DC Offset Compensation (2007)

This paper describes the experimental results of the beat-to-beat interval measurement from a quadrature Doppler radar system utilizing arctangent demodulation with DC offset compensation techniques. The comparison in SDNN and in RMSDD of both signals demonstrates the potential of using quadrature Doppler radar for HRV analysis.
Research note Two new minimum-component Wien-bridge oscillators using current-conveyors (1987)

Two new Wien-bridge oscillator circuits are presented. The circuits use the minimum number of active and passive components. The circuits enjoy low sensitivities, and are attractive for integration. Experimental results are included
Pathophysiology of neuropathic lysosomal storage disorders (2010)

Although neurodegenerative diseases are most prevalent in the elderly, in rare cases, they can also affect children. Lysosomal storage diseases (LSDs) are a group of inherited metabolic neurodegenerative disorders due to deficiency of a specific protein integral to lysosomal function, such as enzymes or lysosomal components, or to errors in enzyme trafficking/targeting and defective function of nonenzymatic lysosomal proteins, all preventing the complete degradation and recycling of macromolecules. This primary metabolic event determines a cascade of secondary events, inducing LSD's pathology. The accumulation of intermediate degradation affects the function of lysosomes and other cellular organelles. Accumulation begins in infancy and progressively worsens, often affecting several organs, including the central nervous system (CNS). Affected neurons may die through apoptosis or necrosis, although neuronal loss usually does not occur before advanced stages of the disease. CNS pathology causes mental retardation, progressive neurodegeneration, and premature death. Many of these features are also found in adult neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's diseases. However, the nature of the secondary events and their exact contribution to mental retardation and dementia remains largely unknown. Recently, lysosomal involvement in the pathogenesis of these disorders has been described. Improved knowledge of secondary events may have impact on diagnosis, staging, and follow-up of affected children. Importantly, new insights may provide indications about possible disease reversal upon treatment. A discussion about the CNS pathophysiology involvement in LSDs is the aim of this review. The lysosomal involvement in adult neurodegenerative diseases will also be briefly described.