gebhart/patrepeval huggingface dataset:
Device for calibrating ultrasensitive accelerometers (1990)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Alain Bernard, Pierre Touboul; Device for calibrating ultrasensitive accelerometers. J. Acoust. Soc. Am. 1 September 1990; 88 (3): 1668. https://doi.org/10.1121/1.400359 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Characterization of early dental caries by polarized Raman spectroscopy (2006)

The early approximal caries lesion in enamel is observed clinically as a white spot and is difficult to detect and/or monitor with current methods available to dentists. New methods with high sensitivity and specificity are required to enable improved early dental caries diagnosis. Using unpolarized Raman spectroscopy to examine unsectioned teeth, peak intensity changes in the phosphate (PO<sub>4</sub><sup>3-</sup>) vibrations (ν<sub>2</sub>, ν<sub>3</sub> and ν<sub>4</sub>) were observed between spectra of sound and carious enamel. However, there is little change in the ν<sub>1</sub> vibration with this approach. In contrast, when tooth sections were examined by unpolarized Raman spectroscopy, marked changes in the ν<sub>1</sub> peak at 959 cm<sup>-1</sup> were noted between healthy and carious enamel. These differences suggest that sampling orientation play a role in understanding the spectral changes. Using polarized Raman spectroscopy to examine unsectioned samples, cross polarized measurements from sound enamel exhibited significant reduction of the ν<sub>1</sub> peak compared with parallel polarized measurements. A similar reduction was observed with carious enamel, however, the reduction was not as prominent. By calculating the depolarization ratio of the area under the ν<sub>1</sub> peak, sound enamel can be clearly distinguished from demineralized regions. The spectral changes observed are attributed to changes in the structure and/or orientation of the apatite crystals as a result of the acid demineralization process.
Trans-palpebral illumination: an approach for wide-angle fundus photography without the need for pupil dilation (2016)

It is technically difficult to construct wide-angle fundus imaging devices due to the complexity of conventional transpupillary illumination and imaging mechanisms. We report here a new method, i.e., trans-palpebral illumination, for wide-angle fundus photography without the need for pupil dilation. By constructing a smartphone-based prototype imaging device, we demonstrated a 152° view in a single-shot image. The unique combination of low-cost smartphone design and automatic illumination optimization promises an affordable solution to conduct telemedicine assessment of eye diseases, which will improve access to eye care for patients in rural and underserved areas.
Duchenne Muscular Dystrophy (2004)

Duchenne muscular dystrophy (DMD) is a common inherited disease with a worldwide incidence of 1 in 3,500 male births. Recent molecular study on the DMD gene identified a 14-kb mRNA encoded by 79 exons distributed over 2.5 million bp of the X-chromosome. The protein named dystrophin contains 3,685 amino acids. Most of the genetic events (mutations) that inactivate the dystrophin gene have been shown to be deletions, with over 65% of patients exhibiting the loss of one or more of the exons at the genomic DNA level. The mechanism of the inactivation of the dystrophin gene in one third of patients with DMD/BMD is unknown.
A simple algorithm for<i>in vivo</i>ocular fundus oximetry compensating for non-haemoglobin absorption and scattering (2002)

An algorithm is introduced for the compensation of the influence of non-haemoglobin absorption as well as tissue scattering on blood spectra used in optical oximetry at the ocular fundus. The in vivo measured spectra were corrected by a linear transformation in order to match the reference spectra of fully oxygenated and reduced blood, respectively, at three isosbestic points (522 nm, 569 nm and 586 nm). The oxygen saturation can then be determined at a wavelength showing a high contrast between oxygenated and reduced haemoglobin (e.g., 560 nm). Reflection measurements at blood flowing through cuvettes were used to validate the algorithm. The oxygen saturation values were compared to measurements of the same samples at a laboratory haemoximeter. The mean deviation was found to be 2.65%.
Diminished immunogenicity of a recombination-deficient derivative of Vibrio cholerae vaccine strain CVD103 (1990)

To address potential concerns over the release of genetically engineered live bacterial vaccines, we constructed a recombination-deficient derivative of the Vibrio cholerae O1 vaccine strain CVD103 (CVD103RM). Oral immunization of adult volunteers with CVD103RM showed that the recA mutation significantly diminished colonization ability and immunogenicity of the vaccine strain.
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule (2015)

Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type (wt) and mut p53, using a yeast-based screening strategy. SLMP53-1 has a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells. Additionally, SLMP53-1 enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K. In wt/mut p53-expressing tumor cells, SLMP53-1 triggers p53 transcription-dependent and mitochondrial apoptotic pathways involving BAX, and wt/mut p53 mitochondrial translocation. SLMP53-1 inhibits the migration of wt/mut p53-expressing tumor cells, and it shows promising p53-dependent synergistic effects with conventional chemotherapeutics. In xenograft mice models, SLMP53-1 inhibits the growth of wt/mut p53-expressing tumors, but not of p53-null tumors, without apparent toxicity. Collectively, besides the potential use of SLMP53-1 as anticancer drug, the tryptophanol-derived oxazoloisoindolinone scaffold represents a promissing starting point for the development of effective p53-reactivating drugs.
Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase Activity (2016)

Current FDA-approved l-asparaginases also possess significant l-glutaminase activity, which correlates with many of the toxic side effects of these drugs. Therefore, l-asparaginases with reduced l-glutaminase activity are predicted to be safer. We exploited our recently described structures of the Erwinia chrysanthemi l-asparaginase (ErA) to inform the design of mutants with diminished ability to hydrolyze l-glutamine. Structural analysis of these variants provides insight into the molecular basis for the increased l-asparagine specificity. A primary role is attributed to the E63Q mutation that acts to hinder the correct positioning of l-glutamine but not l-asparagine. The substitution of Ser-254 with either an asparagine or a glutamine increases the l-asparagine specificity but only when combined with the E63Q mutation. The A31I mutation reduces the substrate Km value; this is a key property to allow the required therapeutic l-asparagine depletion. Significantly, an ultra-low l-glutaminase ErA variant maintained its cell killing ability. By diminishing the l-glutaminase activity of these highly active l-asparaginases, our engineered ErA variants hold promise as l-asparaginases with fewer side effects.
Tnk1/Kos1: a novel tumor suppressor. (2010)

Tnk1/Kos1 is a non-receptor protein tyrosine kinase implicated in negative regulation of cell growth by a mechanism involving inhibition of Ras activation and requiring Tnk1/Kos1's intrinsic catalytic activity. Tnk1/Kos1 null mice were created by homologous recombination by deleting the catalytic domain. Upon aging, both Tnk1+/- and Tnk1-/- mice develop spontaneous tumors, including lymphomas and carcinomas at high rates (i.e. 27%, and 43%, respectively), indicating that Tnk1/Kos1 is a tumor suppressor. Tissues from Tnk1/Kos1-null mice exhibit proportionally higher levels of basal and growth factor-stimulated Ras activation. Mechanistically, Tnk1/Kos1 requires either or both Y277 and Y287 sites to be intact for enzymatic activity and phosphorylation of its substrate, growth factor receptor binding protein 2 (Grb2). Data indicate that following tyrosine phosphorylation of Grb2 by Tnk1/Kos1, the Grb2-Sos1 guanine exchange factor (GEF) complex that mediates growth factor stimulated Ras activation becomes disrupted, resulting in the reversal of Ras activation. Conversely, the loss of Tnk1/Kos1 activity results in constitutive activation of Ras due to prolonged stabilization/activation of the Grb2-Sos1 GEF activity. Tnk1/Kos1 is the first tyrosine kinase discovered to have tumor suppressor activity, and the mechanism of spontaneous tumor formation involves constitutive, indirect activation of Ras. Thus, Ras may display "oncogenic activity" without undergoing "oncogenic" mutation. We now find that a cohort of patients with diffuse large B-cell lymphoma (DLBCL) display downregulation of Tnk1/Kos1 that may account for tumorigenesis in humans.
ChemInform Abstract: 1,1′‐DIPHOSPHAFERROCENES. SYNTHESIS, BASIC CHEMISTRY, AND STRUCTURE (1980)

Abstract Die Darstellungen der 1,I′‐Diphosphaferrocen‐Verbindungen (II) und (IV) erfolgen durch Um‐ /AlCl 3 entsteht ein Gemisch zweier Diastereomerer des 2,2′‐Diacetyl‐Derivats (V).
Pairing an epsilon-negative slab with a mu-negative slab: Resonance, tunneling and transparency (2003)

Here, we analyze the transverse-magnetic (TM) wave interaction with a pair of slabs, one being an epsilon-negative (ENG) layer in which the real part of permittivity is assumed to be negative while its permeability has positive real part, and the other being a mu-negative (MNG) layer that has the real part of its permeability negative but its permittivity has positive real part. Although the wave interaction with each slab by itself has predictable features, we show that the juxtaposition and pairing of such ENG and MNG slabs may, under certain conditions, lead to some unusual features, such as resonance, complete tunneling, zero reflection and transparency. The field distributions inside and outside such paired slabs are analyzed, and the Poynting vector distributions in such structures are studied. Using equivalent transmission-line models, we obtain the conditions for the resonance, complete tunneling and transparency, and we justify and explain the field behavior in these resonant paired structures. Salient features of the tunneling conditions, such as the roles of material parameters, slab thicknesses, dissipation, and angle of incidence are discussed. The analogy and correspondence between the ENG-MNG pair and the pair of a slab of conventional material juxtaposed with a "double-negative" medium is also discussed. Finally, a conceptual idea for a potential application of such a "matched" lossless ENG-MNG pair in "ideal" image displacement and image reconstruction is proposed.
An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics (2015)

There is an urgent unmet need for human tissue bioassays to predict cytokine storm responses to biologics. Current bioassays that detect cytokine storm responses in vitro rely on endothelial cells, usually from umbilical veins or cell lines, cocultured with freshly isolated peripheral blood mononuclear cells (PBMCs) from healthy adult volunteers. These assays therefore comprise cells from 2 separate donors and carry the disadvantage of mismatched tissues and lack the advantage of personalized medicine. Current assays also do not fully delineate mild (such as Campath) and severe (such as TGN1412) cytokine storm-inducing drugs. Here, we report a novel bioassay where endothelial cells grown from stem cells in the peripheral blood (blood outgrowth endothelial cells) and PBMCs from the same donor can be used to create an autologous coculture bioassay that responds by releasing a plethora of cytokines to authentic TGN1412 but only modestly to Campath and not to control antibodies such as Herceptin, Avastin, and Arzerra. This assay performed better than the traditional mixed donor assay in terms of cytokine release to TGN1412 and, thus, we suggest provides significant advancement and a definitive system by which biologics can be tested and paves the way for personalized medicine.
Improving the Lung Delivery of Nasally Administered Aerosols During Noninvasive Ventilation—An Application of Enhanced Condensational Growth (ECG) (2011)

Application of the ECG approach may significantly improve the delivery of pharmaceutical aerosols during NIV and may open the door for using the nasal route to routinely deliver pulmonary medications.
Computational reduction during idle transmission in DSL modems (2002)

This document describes two methods for reducing computational requirements during idle transmission in remote access systems incorporating digital subscriber line (DSL) modems, including asymmetrical DSL (ADSL) systems. These methods save processing power during idle transmission by generating an idle signal using low-complexity techniques. The generated idle signal is made spectrally compatible with xDSL systems and a nondisruptive signaling scheme is used to indicate to the far-end receiver the transition between idle to active or active to idle status. A technique is presented that modulates the phase of the pilot tone to signal status transitions to the remote receiver. The computational complexity at the receiver is reduced because full demodulation and decoding is not required to determine that an idle signal is being transmitted.
Elastic Deformation Error Model for Calibration and Compensation of Parallel Kinematic Mechanism Machine Tool (2012)

In the motion error of parallel kinematic mechanism machine tools, the elastic deformation caused by external forces, such as gravity, as well as the kinematic parameter error, is a significant factor. Internal forces generated by the rotational resistance of passive joints also deform mechanical components. In this paper, an elastic deformation error model that can deal with external and internal forces is presented. A compensation system and a calibration method of kinematic parameters employing this model are also presented. It is experimentally verified that this calibration method and compensation system improve the motion accuracy of a parallel kinematic mechanism machine tool.
An ultrasensitive fiber-optic magnetometer (1986)

A current carrying conductor undergoes displacement in a magnetic field. Using this concept and an all fiber Mach‐Zehnder interferometer, a sensitive magnetometer with theoretical sensitivity on the order of 10−18 Tesla/meter of the fiber has been proposed. This magnetometer will be capable of sensing magnetic field direction as well.
Wafer applied underfills for flip chip assembly (2002)

Manufacturers of consumer electronic products are continuously striving to confer greater functionality to smaller, lighter, and less expensive packages, and flip chip is an important enabling technology for these product trends. Underfill between the die and an organic substrate is necessary to compensate for the coefficient of thermal expansion mismatch. The underfill dispense step is not a typical process for an SMT factory, and demands additional capital equipment, floor space, cycle time and headcount. These additional investments, plus the inability to rework underfilled parts has limited wide scale implementation of flip chip technology. While the application of underfill materials directly to the wafer seems straight forward, many of the material requirements are incompatible with each other. For instance, the necessity of dicing the wafer using water is not compatible with the use of uncured epoxy materials. In addition, the incorporation of fluxing materials into the bulk underfill is known to degrade long-term stability at room temperature. This needs to be addressed, as the stated goal of the program is to provide at least 6 months of on part life prior to use. The methods and materials used to address these concerns are described in the paper. In the placement process, vision recognition of the coated die is critical. Contrast between the solder ball and the underfill as well as the partial coating over the ball can impact the vision system's ability to recognize the die. The results of a vision study are discussed. Finally, coated die are assembled showing good solder wetting with the appropriate coating thickness.
Cationic lipophilic complexes of /sup 99/ /SUP m/ Tc and their use for myocardial and hepatobiliary imaging (1984)

A method of imaging organs with /sup 99/ /SUP m/ Tc radiopharmaceuticals, especially of hepatobiliary imaging and negative myocardial infarct imaging in a mammal which comprises administering to the mammal a hepatobiliary or myocardial imaging amount of a cationic lipophilic complex of Tc-99m and detecting the Tc-99m complex in the mammal. A method for the preparation of cationic lipophilic complexes of Tc-99m.
The Gene Search System: A Method for Efficient Detection and Rapid Molecular Identification of Genes in Drosophila melanogaster (1999)

We have constructed a P-element-based gene search vector for efficient detection of genes in Drosophila melanogaster. The vector contains two copies of the upstream activating sequence (UAS) enhancer adjacent to a core promoter, one copy near the terminal inverted repeats at each end of the vector, and oriented to direct transcription outward. Genes were detected on the basis of phenotypic changes caused by GAL4-dependent forced expression of vector-flanking DNA, and the transcripts were identified with reverse transcriptase PCR (RT-PCR) using the vector-specific primer and followed by direct sequencing. The system had a greater sensitivity than those already in use for gain-of-function screening: 64% of the vector insertion lines (394/613) showed phenotypes with forced expression of vector-flanking DNA, such as lethality or defects in adult structure. Molecular analysis of 170 randomly selected insertions with forced expression phenotypes revealed that 21% matched the sequences of cloned genes, and 18% matched reported expressed sequence tags (ESTs). Of the insertions in cloned genes, 83% were upstream of the protein-coding region. We discovered two new genes that showed sequence similarity to human genes, Ras-related protein 2 and microsomal glutathione S-transferase. The system can be useful as a tool for the functional mapping of the Drosophila genome.
Broadly Tunable Single-Mode Quantum Cascade Laser Source (2007)

We construct a compact broadly tunable single mode quantum cascade laser source that can be used for mid-infrared spectroscopy. The source consists of an array of closely-spaced distributed feedback lasers and a CMOS controller.
Metabolism of [14C]benzyl selenocyanate in the F344 rat (1991)

Benzyl selenocyanate (BSC), a synthetic organoselenium compound, has been shown to inhibit chemically induced tumors in several animal model systems. However, it is not known whether BSC or one of its metabolites is responsible for the chemopreventive effect. An initial approach to this question requires the structural elucidation of BSC metabolites in vitro and in vivo. To determine the structures of BSC metabolites in vitro, we studied the metabolism of [14C]BSC using Aroclor-induced rat liver 9000g supernatant. Under these conditions, BSC was partially converted to dibenzyl diselenide (DDS) and phenylmethaneseleninic acid. The metabolism of [14C]BSC (12.5 mg/kg body weight, 8 mCi/mmol, oral administration) in male F344 rats was also studied. Excretion was monitored by measurement of radioactivity as well as by selenium content using atomic absorption spectrophotometry (AAS). The results indicate that urine was the major route of excretion. Approximately 22% of the dose was excreted in the urine over the course of 35 days; however, a large portion (approximately 70%) of the dose remained in the body. Benzoic acid, hippuric acid, and their sulfate and glucuronide conjugates, accounting for 16% of the dose, were identified in the urine. The formation of these metabolites indicates that BSC is metabolized in part via bond cleavage between the benzyl moiety and the selenocyanate function. Additional support for this cleavage was obtained from fecal analysis; over the course of 23 days 9% of the selenium (AAS) but only less than 1% of the radioactivity was recovered in feces. No radioactivity was detected in the exhaled air. We also studied the metabolism of [14C]DDS (17.3 mg/kg body weight, 2.5 mCi/mmol) in male F344 rats.(ABSTRACT TRUNCATED AT 250 WORDS)
6.7 A 2.3mW 11cm-range bootstrapped and correlated-double-sampling (BCDS) 3D touch sensor for mobile devices (2015)

Contactless (3D) touch sensors, when integrated with displays, offer many advantages over that of conventional touch-panel screens by offering a more hygienic and a more immersive & interactive human/machine interface for 3D user experiences [1]. While significant progress has been made in developing 3D contactless touch sensors for larger television and monitor type displays [2-3], the technology has yet to be infused into space- and battery-constrained mobile devices (i.e., tablets and smartphones). For successful insertions into these systems, a paradigm shift in touch-sensor system design is essential to enable seamless sensing operations with smaller-size, more tightly spaced, strongly coupled, and highly resistive display electrodes. In addition, any successful 3D sensing solution for mobile devices must consume low power and small silicon area to be compatible with limited battery and space resources.
Gesture Recognition Using Wireless Signals (2015)

column Share on Gesture Recognition Using Wireless Signals Authors: Qifan Pu University of Washington University of WashingtonView Profile , Sidhant Gupta University of Washington University of WashingtonView Profile , Shyamnath Gollakota University of Washington University of WashingtonView Profile , Shwetak Patel University of Washington University of WashingtonView Profile Authors Info & Claims GetMobile: Mobile Computing and CommunicationsVolume 18Issue 4October 2014 pp 15–18https://doi.org/10.1145/2721914.2721919Published:13 January 2015Publication History 17citation571DownloadsMetricsTotal Citations17Total Downloads571Last 12 Months31Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access