gebhart/patrepeval huggingface dataset:
Adipose Tissue Fat Accumulation Is Reduced by a Single Intraperitoneal Injection of Peroxisome Proliferator-Activated Receptor Gamma Agonist When Given to Newly Hatched Chicks (2008)

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a transcription factor that regulates adipocyte differentiation and modulates lipid metabolism in mammals. The aim of the present study was to investigate whether the administration of PPARgamma ligands, adipogenic cocktail, or both to newly hatched chicks regulates adipocyte differentiation in vivo and modulates fat deposition in growing broiler chickens. Levels of PPARgamma, CCAAT/enhancer binding protein alpha, and adipocyte fatty acid-binding protein mRNA in the abdominal fat pad of 7-d-old broiler chicks given a single intraperitoneal dose of troglitazone, a synthetic PPARgamma ligand, at 1 d old were significantly greater than those in control chickens. This suggests administration of troglitazone enhanced adipocyte differentiation in vivo. Adipose tissue weight in 28-d-old chickens similarly administered triolein emulsion containing troglitazone or adipogenic cocktail (i.e., dexamethasone, insulin, isobutyl-methylxanthine, and oleic acid) was also significantly less than that of control chickens. However, there was no significant difference in BW between treated and control chickens. Although BW and carcass composition were not different between troglitazone-treated and control chickens, at 48 d of age abdominal fat pad weight and feed intake were significantly decreased in chickens treated with troglitazone compared with controls. These results demonstrate that a single intraperitoneal injection of troglitazone to newly hatched chicks reduces fat deposition in mature broiler chickens.
Insider Threat Detection Based on User Behavior Modeling and Anomaly Detection Algorithms (2019)

Insider threats are malicious activities by authorized users, such as theft of intellectual property or security information, fraud, and sabotage. Although the number of insider threats is much lower than external network attacks, insider threats can cause extensive damage. As insiders are very familiar with an organization’s system, it is very difficult to detect their malicious behavior. Traditional insider-threat detection methods focus on rule-based approaches built by domain experts, but they are neither flexible nor robust. In this paper, we propose insider-threat detection methods based on user behavior modeling and anomaly detection algorithms. Based on user log data, we constructed three types of datasets: user’s daily activity summary, e-mail contents topic distribution, and user’s weekly e-mail communication history. Then, we applied four anomaly detection algorithms and their combinations to detect malicious activities. Experimental results indicate that the proposed framework can work well for imbalanced datasets in which there are only a few insider threats and where no domain experts’ knowledge is provided.
Performance Evaluation for Local Anchor-Based Dual Connectivity in 5G User-Centric Network (2016)

Ultra-dense network (UDN) is considered as one of the most promising techniques in achieving the increasingly explosive growth of data rates for future 5G system. However, a large number of small cells lead to the increased cell edges and the rugged inter-cell interference, which cause frequent handover events and more radio link failure. In this paper, a local anchor-based dual connectivity (DC) architecture is proposed for a user-centric network based on the analysis of mobility management challenges of UDN. Under the proposed architecture, the local anchor acts as the master eNodeB (MeNB) with neighboring small cells acting as slave eNodeBs (SeNBs) to provide DC transmission for user-centric service following each user's movement. Key procedures for mobility management are correspondingly provided and both the MeNBs and SeNBs are selected from the small cells to investigate the potential of them, which are different from the mobility management methods under the traditional cellular architecture. Performance evaluations are conducted under different parameter configurations to evaluate the maximum potential of the proposed scheme. Simulation results show that in our proposed scheme, the handover failure rate shows a maximum decrease of more than 53% and the average user spectrum efficiency achieves an increase of 5% gains over the current LTE system when the user equipment speed is 3 km/h.
Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. (1994)

The integrin beta 8 subunit was identified by cloning and sequencing of the cDNA and has been shown to associate with the alpha v subunit (Moyle, M., Napier, M. A., and McLean, J. W. (1991) J. Biol. Chem. 266, 19650-19658). We now present initial data on its functional properties. We produced a recombinant secreted form of alpha v beta 8 and used it to raise monoclonal antibodies that recognize the alpha v beta 8 complex or the beta 8 subunit alone on the surface of melanoma cells and on beta 8-transfected human embryonic kidney (293) cells. Affinity chromatography experiments showed that secreted alpha v beta 8 bound to vitronectin but not to fibronectin, collagen, or fibrinogen. Supporting evidence that intact full-length alpha v beta 8 could also bind to vitronectin-Sepharose was provided by performing affinity chromatography with the melanoma cell line MeWo, which normally expresses the intact beta 8 subunit. By studying the adhesive properties of melanoma cells and beta 8-transfected 293 cells, we found that alpha v beta 8 by itself does not promote cell adhesion on a vitronectin-coated substrate. To test the respective functional activities of the beta 8 extracellular and cytoplasmic domains, we analyzed chimeric beta 8/beta 3 subunit constructs. The beta 3 subunit was chosen because full-length beta 3, when transfected into 293 cells, strongly supports cell adhesion. We found that a chimeric integrin containing the beta 3 extracellular domain combined with the beta 8 transmembrane and cytoplasmic domains did not promote 293 cell adhesion. Conversely, a chimeric integrin construct combining the beta 8 extracellular domain with the beta 3 transmembrane and cytoplasmic domains did promote adhesion of transfected 293 cells. This suggests that the beta 8 cytoplasmic domain does not interact with the cytoskeleton and with cytoplasmic signaling pathways in an adhesion-promoting fashion. We conclude that the beta 8 cytoplasmic domain, which is structurally unrelated to the conserved cytoplasmic domains of other beta subunits, is functionally distinct.
Design and Implementation of a Mobile Single-Phase AC Power Supply for Land Vehicles with 28V/200V Dual Voltage Alternators (2003)

<div class="htmlview paragraph">In land vehicles with high-power electrical loads, other than the low-voltage DC bus (14V, 28V, or 42V) for the low-power conventional loads, a high-voltage bus, e.g., 200V DC, is required for high-power loads such as hotel loads and electrically-assisted propulsion systems. In addition, some advanced electrical loads including luxury loads and AC power point require 120V, 60Hz AC voltage. These land vehicles include heavy duty, fire fighting, and military vehicles. There are two traditional approaches in obtaining a dual DC voltage bus system. The first one is to obtain the low-voltage DC from the alternator and boost it to the high-voltage DC. The second method is to obtain the high-voltage DC directly from the alternator and reduce it to the low-voltage. Both approaches require additional step-up or step-down power conversion stages, which inherently result in a reduced efficiency. In this paper, a new approach with a 28V/200V dual voltage alternator is considered. This system avoids the additional power conversion stage and, as a result, increases the efficiency of the system.</div> <div class="htmlview paragraph">The primary objective of this paper is to demonstrate the design and operation of a high power density, 2.5 kW, single-phase, DC/AC pulse width modulated (PWM) inverter. The IGBT-based inverter operates from the 200V DC voltage output of the dual voltage alternator and consists of a low-pass LC filter at its output. The RMS value of the AC output voltage attained from the mobile power supply is 120V at a frequency of 60Hz. The sinusoidal pulse width modulation (SPWM) method is used as the control technique for the purpose of inverter switching. These PWM control signals are generated using a digital signal processor (DSP) and are eventually used to drive the gates of the IGBT switches of the proposed inverter. Due to the simplified power stage and the usage of an efficient DSP-based modulation technique, the total harmonic distortion (THD) of the output voltage is fairly low (less than 2%) and a relatively small overall inverter size is achieved. A detailed description of the system along with simulation and experimental results are presented in this paper.</div>
CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use (2005)

The real-time RT-PCR technique based on a RNA standard curve, CyProQuant-PCR, outlined here, allows for a genuine absolute quantification and a simultaneous analysis of a large panel of human cytokine mRNA. It represents a potent and attractive tool for immunomonitoring, lending itself readily to automation and with a high throughput. This opens the possibility of an easy and reliable cytokine profiling for clinical applications.
Reducing NVH Analysis Burden Using Automated Multi-level Substructuring #164 (1999)

The Automated Multi-Level Substructuring (AMLS) method has been developed to reduce the computational demands of Noise, Vibration and Harshness (NVH) analysis and extend frequency response capabilities to higher frequencies and higher levels of accuracy AMLS automatically divides a large finite element model into thousands of substructures on dozens of levels. and expresses finite element displacements in terms of substructure eigenvectors Transforming a model to the substructure mode basis is much less expensive than obtaining a global eigensolution using conventional methods. After the transformation has been done, obtaining a global eigensolution or global frequency response functions is very inexpensive This paper compares AMLS with the conventional modal frequency response method for NVH analvsis and demonstrates the reductions in CPU time, memory, and I/O that are achieved on a large finite element model of a car body These results indicate that AMLS will enable NVH analysis to be done on massively parallel processor (MPP) systems rather than on the vector supercomputers that are currently used.
Leptin‐mediated cytokine release and migration of eosinophils: Implications for immunopathophysiology of allergic inflammation (2007)

Leptin is a pleiotropic adipocyte-derived cytokine used in hypothalamic regulation of body weight and modulation of immune response by stimulating T cells, macrophages and neutrophils. Leptin has been shown to be an eosinophil survival factor. We examined the immunopathological mechanisms for the activation of human eosinophils from healthy volunteers by leptin in allergic inflammation. Adhesion molecules, cytokines and cell migration were assessed by flow cytometry, ELISA and Boyden chamber assay, respectively. Intracellular signaling molecules were investigated by membrane array and Western blot. Leptin could up-regulate cell surface expression of adhesion molecule ICAM-1 and CD18 but suppress ICAM-3 and L-selectin on eosinophils. Leptin could also stimulate the chemokinesis of eosinophils, and induce the release of inflammatory cytokines IL-1beta and IL-6, and chemokines IL-8, growth-related oncogene-alpha and MCP-1. We found that leptin-mediated induction of adhesion molecules, release of cytokines and chemokines, and chemokinesis were differentially regulated by the activation of ERK, p38 MAPK and NF-kappaB. In view of the above results and elevated production of leptin in patients with allergic diseases such as atopic asthma and atopic dermatitis, leptin could play crucial immunopathophysiological roles in allergic inflammation by activation of eosinophils via differential intracellular signaling cascades.
Inheritance of Chromosomally Integrated Human Herpesvirus 6 DNA (1999)

Human herpesvirus 6 (HHV-6) genome has been detected in several human lymphoproliferative disorders with no signs of active viral infection, and found to be integrated into chromosomes in some cases. We previously reported a woman with HHV-6-infected Burkitt's lymphoma. Fluorescence in situ hybridization showed that the viral genome was integrated into the long arm of chromosome 22 (22q13). The patient's asymptomatic husband also carried HHV-6 DNA integrated at chromosome locus 1q44. To assess the possibility of chromosomal transmission of HHV-6 DNA, we looked for HHV-6 DNA in the peripheral blood of their daughter. She had HHV-6 DNA on both chromosomes 22q13 and 1q44, identical to the site of viral integration of her mother and father, respectively. The findings suggested that her viral genomes were inherited chromosomally from both parents. The 3 family members were all seropositive for HHV-6, but showed no serological signs of active infection. To confirm the presence of HHV-6 DNA sequences, we performed polymerase chain reaction (PCR) with 7 distinct primer pairs that target different regions of HHV-6. The viral sequences were consistently detected by single-step PCR in all 3 family members. We propose a novel latent form for HHV-6, in which integrated viral genome can be chromosomally transmitted. The possible role of the chromosomally integrated HHV-6 in the pathogenesis of lymphoproliferative diseases remains to be explained.
Inhibitor Discovery Targeting the Intermediate Structure of β-Amyloid Peptide on the Conformational Transition Pathway:  Implications in the Aggregation Mechanism of β-Amyloid Peptide (2006)

Abeta peptides cleaved from the amyloid precursor protein are the main components of senile plaques in Alzheimer's disease. Abeta peptides adopt a conformation mixture of random coil, beta-sheet, and alpha-helix in solution, which makes it difficult to design inhibitors based on the 3D structures of Abeta peptides. By targeting the C-terminal beta-sheet region of an Abeta intermediate structure extracted from molecular dynamics simulations of Abeta conformational transition, a new inhibitor that abolishes Abeta fibrillation was discovered using virtual screening in conjunction with thioflavin T fluorescence assay and atomic force microscopy determination. Circular dichroism spectroscopy demonstrated that the binding of the inhibitor increased the beta-sheet content of Abeta peptides either by stabilizing the C-terminal beta-sheet conformation or by inducing the intermolecular beta-sheet formation. It was proposed that the inhibitor prevented fibrillation by blocking interstrand hydrogen bond formation of the pleated beta-sheet structure commonly found in amyloid fibrils. The study not only provided a strategy for inhibitor design based on the flexible structures of amyloid peptides but also revealed some clues to understanding the molecular events involved in Abeta aggregation.
An Effective Pd–Ni<sub>2</sub>P/C Anode Catalyst for Direct Formic Acid Fuel Cells (2013)

The direct formic acid fuel cell is an emerging energy conversion device for which palladium is considered as the state-of-the-art anode catalyst. In this communication, we show that the activity and stability of palladium for formic acid oxidation can be significantly enhanced using nickel phosphide (Ni(2)P) nanoparticles as a cocatalyst. X-ray photoelectron spectroscopy (XPS) reveals a strong electronic interaction between Ni(2)P and Pd. A direct formic acid fuel cell incorporating the best Pd–Ni(2)P anode catalyst exhibits a power density of 550 mWcm(-2), which is 3.5 times of that of an analogous device using a commercial Pd anode catalyst.
Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma (1989)

Twenty vertebral bones, 11 costal, 11 epiglottic, six tracheal, and five bronchial cartilages and seven chordomas were evaluated by the application of peroxidase-antiperoxidase (PAP) indirect immunohistochemical method for localization of glial fibrillary acidic protein (GFAP). Positive immunostaining for GFAP was observed in osteocytes of normal bone (13/20), chondrocytes of normal epiglottis (5/11), costal cartilage (3/11), trachea (2/6), and bronchus (4/5). Four of seven chordomas had neoplastic cells that exhibited cytoplasmic positivity to GFAP. These findings suggested that osteocytes, chondrocytes, and chordoma cells have cytoskeletal intermediate filaments that are antigenically identical to or similar to or associated with GFAP.
Electrorotational studies of the cytoplasmic dielectric properties of Friend murine erythroleukaemia cells (1995)

Electrorotation (ROT) spectra of Friend murine erythroleukaemia DS19 cells were measured in the frequency range 10 kHz-100 MHz as a function of suspension osmolality and cell differentiation treatment with hexamethylene bisacetamide (HMBA). A minimization program was employed to curve-fit the measured spectra using a single-shell dielectric model, allowing the derivation of cellular interior conductivity and permittivity (valid for the frequency range 10-100 MHz) and the cytoplasmic membrane capacitance (its dependence on the cell differentiation state and suspension osmolality having been reported earlier). Following HMBA treatment, DS19 cells exhibited a slight increment in average interior permittivity and a decrement in interior conductivity, although the changes were not statistically significant. For both untreated and HMBA treated samples, the average interior conductivity increased and permittivity decreased with increasing suspension osmolality. Of significance was that the average permittivity of cell interiors was larger than that of pure water. The electrorotation spectra of freshly prepared cell nuclei were measured, and the derived nuclear dielectric parameters were employed in numerical simulations to investigate the effects of nuclei on the ROT spectra of intact cells. Other cellular internal structures such as mitochondria were also analysed using theoretical simulations. It was concluded that the derived large permittivity values did not result from cell nuclei or mitochondria, and, instead, we suggest that they may arise from the combined effects of several cytoplasmic organelles.
Role of KCNMA1gene in breast cancer invasion and metastasis to brain (2009)

Determining the relative abundance of BKCa channel expression in breast cancer metastatic to brain and the mechanism of its action in brain metastasis will provide a unique opportunity to identify and differentiate between low grade breast tumors that are at high risk for metastasis from those at low risk for metastasis. This distinction would in turn allow for the appropriate and efficient application of effective treatments while sparing patients with low risk for metastasis from the toxic side effects of chemotherapy.
Intellectual Property in Transition Economies: Assessing the Latvian Experience (2003)

emerged from the Soviet Union burdened by the legacy of fifty years of Soviet socialism in all areas of the state and the economy.Like many of the former socialist states of Central and Eastern Europe, Latvia embarked upon an ambitious transition program to establish its political participation in modern Europe and economic participation in the global market.Having restored its pre-Soviet constitution and institutions by 1993, 1 Latvia set about to re-order its economy by taking private property as the basis of a marketoriented economy with both public and private sector participation.In matters relating to intellectual property, Latvia inherited the Soviet system, which formally subjugated the interests of inventors, authors, artists, and recorded performers to those of the "state of the whole people." 2 In addition to pressure from the developed Western economies, several other factors prompted Latvia to recognize the importance of granting private property rights in intellectual products: its emergence from the socialist bloc at precisely the time that intellectual property was assuming a significant role in the world economy, the fall of socialism in Europe coinciding with the commercialization of the Internet, and the rise of the so-called "new economy."Moreover, an effective recognition and commercial exploitation of intellectual property rights also required the development of the appropriate institutions.Thus, while ownership of company stock or valuable tangible assets such as real estate were given the highest priority in Latvia's *
TBD-catalysed solventless synthesis of symmetrically N,N′-substituted ureas from primary amines and diethyl carbonate (2003)

Symmetrically N,N′-substituted ureas were obtained from primary amines in very good yields under solvent-less conditions using diethyl carbonate (DEC) as the carbonylation reagent and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the base catalyst. The products are precipitated directly from the reaction mixture after a volatile organic compound (VOC) free aqueous work-up. The catalyst can be recovered and reused.
Electrophysiologic Analysis of a Chronic Seizure Model After Unilateral Hippocampal KA Injection (1999)

The electrographic features of spontaneous seizures in the KA-treated rat resemble those of patients with medically refractory TLE with respect to EEG pattern and localization. Our data suggest that hypersynchronous ictal onsets represent epileptogenic disturbances in hippocampal circuits, whereas LVF ictal onsets may involve extrahippocampal areas having more direct connections to the motor system. Hypersynchronous seizures may involve the same neuronal mechanisms that generate interictal FRs.
Selenium Is Mobilized In Vivo from Free Selenocysteine and Is Incorporated Specifically into Formate Dehydrogenase H and tRNA Nucleosides (2002)

Selenophosphate synthetase (SPS), the selD gene product from Escherichia coli, catalyzes the biosynthesis of monoselenophosphate, AMP, and orthophosphate in a 1:1:1 ratio from selenide and ATP. It was recently demonstrated that selenium delivered from selenocysteine by an E. coli NifS-like protein could replace free selenide in the in vitro SPS assay for selenophosphate formation (G. M. Lacourciere, H. Mihara, T. Kurihara, N. Esaki, and T. C. Stadtman, J. Biol. Chem. 275:23769-23773, 2000). During growth of E. coli in the presence of 0.1 microM (75)SeO(3)(2-) and increasing amounts of L-selenocysteine, a concomitant decrease in (75)Se incorporation into formate dehydrogenase H and nucleosides of bulk tRNA was observed. This is consistent with the mobilization of selenium from L-selenocysteine in vivo and its use in selenophosphate formation. The ability of E. coli to utilize selenocysteine as a selenium source for selenophosphate biosynthesis in vivo supports the participation of the NifS-like proteins in selenium metabolism.