gebhart/patrepeval huggingface dataset:
Cold Sintered Metal–Ceramic Nanocomposites for High‐Frequency Inductors (2020)

Abstract Power electronics, including those inspired by 5G and 6G revolutions, have escalated the demand for miniaturized energy‐efficient inductor components with higher power density, higher operating frequencies, and smaller device sizes. Recently, cold sintering has proved to be a powerful tool for fabricating ceramics. Here, novel metal–ceramic nanocomposites are prepared by cold sintering for the first time. As a model system, Fe‐based nanocrytalline alloys with NiZn ferrites and α‐Fe 2 O 3 ceramics are cold sintered at 150 °C under a uniaxial pressure of 320 MPa. These nanocomposites illustrate dense microstructures, fine grains, and high electrical resistivities, allowing remarkable high‐frequency performance, such as permeability values of ≈11.5 at frequencies up to ≈1 GHz with corresponding quality factors reaching over 100 at tens of megahertz. The power inductors using the developed composite materials demonstrate low DC resistance (18.35 mΩ), high efficiency (≈98.2%), and high current rating with small form factors far superior to those available as commercial products. The results presented here indicate a dramatic advance in the materials science and development of inductor composite materials for power electronics applications. This synthesis route of metal–ceramic composites shows great potential in fabrication of new composite materials that are targeted for functional components.
Transactions in dynamic reactive environments (2015)

perpétuo e sem limites geográficos, de arquivar e publicar esta dissertação através de ex-emplares impressos reproduzidos em papel ou de forma digital, ou por qualquer outro meio conhecido ou que venha a ser inventado, e de a divulgar através de repositórios científicos e de admitir a sua cópia e distribuição com objectivos educacionais ou de in-vestigação, não comerciais, desde que seja dado crédito ao autor e editor. iv To my parents vi Acknowledgements First and foremost, I need to sincerely thank my supervisor, José Júlio Alferes, for his in-credible support and expertise. Even as Head of the department or as faculty Vice-Dean, he always managed to be available to help and advise me, or just to calmme downwhen-ever I reached (one of the too many) dead ends. I really appreciated all our discussions either scientific, political, or just on random subjects. Thank you for givingme confidence to grow, for teaching me how to be a researcher, and for magically providing for all my
Interactive aerial projection of 3D hologram object (2016)

In this paper we present an interactive aerial projection of 3D hologram objects by using the pyramid hologram and parabolic mirror system (for 3D hologram object reconstruction) and the Leap Motion sensor (as a finger movement detector of a user). This system not only can reconstruct and project the 3D hologram object in the mid-air, but also provides a way to interact with it by moving a user's finger. There are three main steps: the reconstruction of 3D object, the projection of 3D hologram object in the mid-air, and the interactive manipulation of 3D hologram object. The first step is realized by using pyramid hologram with LCD display. The second step is achieved with the parabolic mirror hologram. And Leap Motion sensor is used for the last step to detect user finger movement. This paper traces the design concept and confirms the system function of an interactive aerial projection of 3D hologram objects by a prototype demonstration.
Complete Nucleotide Sequence of the Nucleoprotein Gene from the Human Influenza Strain A/PR/8/34 (HON1) (1981)

The complete nucleotide sequence of the influenza A/PR/8/34 nucleoprotein gene was determined after cloning for dsDNA copy in pBR322. The nucleoprotein gene is 1517 nucleotides long of which 1446 nucleotides code for 482 amino acids. The calculated amino acid composition is in good agreement with those published for influenza A nucleoprotein genes. The amino acid sequence of the nucleoprotein contains clusters of basic amino acids and proline, a property shared with other nucleic-acid-associated proteins like Semliki forest virus nucleocapsid protein, VP1 protein of polyoma virus and Simian virus 40, and the core antigen of hepatitis B virus. The described nucleoprotein structure brings the number of sequenced genes of influenza A/PR/8/34 to five out of eight genes.
Time‐dependent inhibition of porcine kidney trehalase by aminosugars (1990)

The inhibitory effects of various nitrogen-containing sugars on porcine kidney trehalase were studied. Validamycin A, validoxylamine A and MDL 25,637 were found to be potent, time-dependent inhibitors of the enzyme in vitro. The validoxylamine A-inhibited enzyme showed slow but reversible reactivation over time (t1/2 = 1.2 h). To our knowledge, this is the first report of time-dependent inhibition exhibited by either these particular aminosugars or a trehalase.
A Scalable Approach to Probabilistic Latent Space Inference of Large-Scale Networks (2018)

We propose a scalable approach for making inference about latent spaces of large networks. With a succinct representation of networks as a bag of triangular motifs, a parsimonious statistical model, and an efficient stochastic variational inference algorithm, we are able to analyze real networks with over a million vertices and hundreds of latent roles on a single machine in a matter of hours, a setting that is out of reach for many existing methods. When compared to the state-of-the-art probabilistic approaches, our method is several orders of magnitude faster, with competitive or improved accuracy for latent space recovery and link prediction.
Application of HPLC for the screening of separation of new macrocyclic systems (2016)

GRAPHICAL ABSTRACTApplication of HPLC for the screening of separation of new macrocyclic systemsAll authorsMonika Stefaniak & Jarosław Romańskihttps://doi.org/10.1080/10426507.2016.1255622Published online:10 November 2016
[Efforts toward the formulation of the therapeutic stereoisomer of ibuprofen]. (1993)

In an on going effort to optimize ibuprofen antiinflammatory therapy, development studies on the active stereoisomer of ibuprofen have been conducted. The effects of pharmaceutical processing on the racemate (RAC-ibuprofen) and the enantiomer (S(+)-ibuprofen) were investigated. The formulation of the new stereospecific system, was impossible using wet granulation. The pharmaceutical development of S(+)-ibuprofen using direct compression appeared as a practical solution to this problem. The biopharmaceutical properties of the resulting tablets were well within pharmacopeia requirements. Nevertheless, mixing S(+)-ibuprofen with the excipients induced a drop in the enthalpy of fusion and after compaction, a low temperature eutectic appeared on the differential scanning calorimetry endotherms. Aging studies indicated that the raw material and pharmaceutical mixtures of S(+)-ibuprofen should be stored under strictly controlled conditions or processed immediately.
Mostly static program partitioning of binary executables (2009)

We have built a runtime compilation system that takes unmodified sequential binaries and improves their performance on off-the-shelf multiprocessors using dynamic vectorization and loop-level parallelization techniques. Our system, Azure, is purely software based and requires no specific hardware support for speculative thread execution, yet it is able to break even in most cases; that is, the achieved speedup exceeds the cost of runtime monitoring and compilation, often by significant amounts. Key to this remarkable performance is an offline preprocessing step that extracts a mostly correct control flow graph (CFG) from the binary program ahead of time. This statically obtained CFG is incomplete in that it may be missing some edges corresponding to computed branches. We describe how such additional control flow edges are discovered and handled at runtime, so that an incomplete static analysis never leads to an incorrect optimization result. The availability of a mostly correct CFG enables us to statically partition a binary executable into single-entry multiple-exit regions and to identify potential parallelization candidates ahead of execution. Program regions that are not candidates for parallelization can thereby be excluded completely from runtime monitoring and dynamic recompilation. Azure's extremely low overhead is a direct consequence of this design.
New <scp>BAR</scp> tools for mining expression data and exploring <i>Cis</i>‐elements in <i>Arabidopsis thaliana</i> (2016)

Identifying sets of genes that are specifically expressed in certain tissues or in response to an environmental stimulus is useful for designing reporter constructs, generating gene expression markers, or for understanding gene regulatory networks. We have developed an easy-to-use online tool for defining a desired expression profile (a modification of our Expression Angler program), which can then be used to identify genes exhibiting patterns of expression that match this profile as closely as possible. Further, we have developed another online tool, Cistome, for predicting or exploring cis-elements in the promoters of sets of co-expressed genes identified by such a method, or by other methods. We present two use cases for these tools, which are freely available on the Bio-Analytic Resource at http://BAR.utoronto.ca.
A Lagrangian Decomposition Algorithm for Optimal Emergency Voltage Control (2010)

Voltage control problems typically involve large networks comprising diverse components extending over considerable areas and interconnecting different grids and operators. To deal with such systems, there has been over the past few years a steadily increasing interest in model predictive/optimal control techniques as a viable solution. In such a setting, it is essential to be able to coordinate the control actions among the various grids while preserving sensitive local system data that regional operators are often not willing to disclose. In view of these discordant factors, centralized and decentralized control schemes, respectively, yield advantages and drawbacks: the former require global system data to be accessible whereas the latter may prove to be difficult to effectively implement or might achieve suboptimal performance. The present paper therefore proposes a centralized control scheme that is solved however in a distributed fashion through a Lagrangian decomposition algorithm, thus reaping the benefits of both approaches: the control problem is global, therefore intrinsically more reliable and comprehensive, but only local information is employed to achieve the overall optimum control input. The computational delay associated with the additional iterations required by the algorithm is shown to be viable for the considered application and can furthermore be inherently accounted for within the proposed optimal control scheme.
The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation. (1987)

In vitro-transcribed human interferon-beta (IFN-beta) mRNA, which contains all the sequence of the natural molecule, is poorly translated in a reticulocyte lysate or when injected in Xenopus oocytes. This low level of translation is due to an inhibition by the 5' and 3' untranslated regions (UTRs). Indeed, the replacement of these sequences by those of Xenopus beta-globin mRNA dramatically increases the translational efficiency of the mRNA, especially in oocytes. This phenomenon is not due to a difference in mRNA stability since both native and chimeric mRNAs remain undegraded, at least during the translation period considered. Construction of different chimeric molecules having various combinations of 5' and 3' UTRs from IFN-beta or Xenopus beta-globin mRNA or a small sequence of SP6 polylinker as 5' UTR has revealed that the 3' UTR of IFN-beta in itself has a pronounced inhibitory effect on translation in the two translation systems from animal cells. Indeed, the addition of this 3' UTR at the 3' end of the coding region of a chicken lysozyme mRNA also causes a large decrease of its translational capacity in both systems. However, the nature of the 5' noncoding sequence influences the degree of translation inhibition exerted by the 3' UTR. Remarkably, we observed no difference in translation level when the different mRNAs were tested in a wheat germ extract.
Charred Wood Stimulated Germination of Two Fire-Following Herbs of the California Chaparral and the Role of Hemicellulose (1986)

Germination of the fire-following chaparral herbs, Emmenanthe penduliflora (Hydrophyllaceae) and Eriophyllum confertiflorum (Asteraceae), previously has been shown to be stimulated by charred wood from the widespread chaparral shrub Adenostoma fasciculatum (Rosaceae). A series of investigations undertaken to clarify this effect gave the following results. Light is not required, but may enhance the response. The effect is not limited to A. fasciculatum but is produced by a wide variety of chaparral and non-chaparral woods. Charring is not necessary; wood heated to 175 C for 30 min produced the same germination stimulation. The stimulatory compound is water soluble, effective within 24 hr exposure and active at 0.04 g/50 cc soil. Germination was stimulated by heated xylan, a hemicellulose, and by heated glucuronic acid, a common side chain of xylan and other hemicelluloses. Heating produced changes in the color and consistency of xylan and glucuronic acid. An oligosaccharin-type molecule is postulated to be produced by heating xylan or other hemicelluloses with glucuronic acid side chains. Previously described oligosaccharins are derived from galactouronic acid and xyloglucan which are structurally and functionally related to compounds tested here.
Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction (2016)

The number of HIV-1 positive individuals developing some form of HIV-associated neurocognitive disorder (HAND) is increasing. In these individuals, the integrity of the blood-brain barrier (BBB) is compromised due to an increase in exposure to pro-inflammatory mediators, viral proteins, and virus released from infected cells. It has been shown that soluble CD40L (sCD40L) is released upon platelet activation and is an important mediator of the pathogenesis of HAND but the underlying mechanisms are unclear, emphasizing the need of an effective animal model. Here, we have utilized a novel animal model in which wild-type (WT) mice were infected with EcoHIV; a derivative of HIV-1 that contains a substitution of envelope protein gp120 with that of gp80 derived from murine leukemia virus-1 (MuLV-1). As early as two-weeks post-infection, EcoHIV led to increased permeability of the BBB associated with decreased expression of tight junction protein claudin-5, in CD40L and platelet activation-dependent manner. Treatment with an antiplatelet drug, eptifibatide, in EcoHIV-infected mice normalized BBB function, sCD40L release and platelet activity, thus implicating platelet activation and platelet-derived CD40L in virally induced BBB dysfunction. Our results also validate and underscore the importance of EcoHIV infection mouse model as a tool to explore therapeutic targets for HAND.
Elevated Plasma Transforming Growth Factor-β1 Levels in Breast Cancer Patients Decrease After Surgical Removal of the Tumor (1995)

Breast tumors result in increased plasma TGF-beta 1 levels in 81% of patients. After surgical removal of the primary tumor, the plasma TGF-beta 1 level normalizes in the majority of patients; persistently elevated levels correlate with the presence of lymph node metastases or overt residual tumor. These findings suggest that the usefulness of TGF-beta 1 as a potential plasma marker for breast tumors deserves further study.
AXIOMATIC DESIGN OF CUSTOMIZABLE AUTOMOTIVE SUSPENSION (2004)

The design of existing suspension systems typically involves a compromise solution for the conflicting requirements of comfort and handling. For instance, cars need a soft suspension for better comfort, whereas a stiff suspension leads to better handling. Cars need high ground clearance on rough terrain, whereas a low center of gravity (CG) height is desired for swift cornering and dynamic stability at high speeds. It is advantageous to have low damping for low force transmission to vehicle frame, whereas high damping is desired for fast decay of oscillations. To eliminate these trade-offs, a novel design for a customizable automotive suspension system with independent control of stiffness, damping and ride-height is proposed in this thesis. This system is capable of providing the desired performance depending on user preference, vehicle speed, road conditions and maneuvering inputs. The design, fabrication and control of the customizable suspension prototype are discussed. The application of variable stiffness and variable ride-height suspension system to achieve improved vehicle dynamics is studied. Application to control of vehicle dynamics parameters required bandwidth and power input beyond the capability of the first prototype. To eliminate the bandwidth restrictions of the
Syntheses of 1- and 2-naphthol analogs of DL-tyrosine. Potential fluorescent probes of peptide structure and dynamics in complex environments (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of 1- and 2-naphthol analogs of DL-tyrosine. Potential fluorescent probes of peptide structure and dynamics in complex environmentsMarco A. Vela, Frank R. Fronczek, Gregory W. Horn, and Mark L. McLaughlinCite this: J. Org. Chem. 1990, 55, 9, 2913–2918Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/jo00296a064https://doi.org/10.1021/jo00296a064research-articleACS PublicationsRequest reuse permissionsArticle Views1120Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
In Vitro Evaluation of Antisense RNA Efficacy against Filovirus Infection, by Use of Reverse Genetics (2007)

Minigenome screening appears to be an effective and convenient method of evaluating the therapeutic potential of siRNA targets, and findings suggest that its use would increase success rates in later stages of siRNA testing.
Mitigating man-in-the-middle attacks on mobile devices by blocking insecure http traffic without using vpn (2018)

Mobile devices are constantly connected to the Internet, making countless connections with remote services. Unfortunately, many of these connections are in cleartext, visible to third-parties while in transit. This is insecure and opens up the possibility for man-in-the-middle attacks. While there is little control over what kind of connection running apps can make, this paper presents a solution in blocking insecure HTTP packets from leaving the device. Specifically, the proposed solution works on the device, without the need to tunnel packets to a remote VPN server, and without special privileges such as root access. Speed tests were performed to quantify how much network speed is being impacted while filtering. To investigate how blocking HTTP traffic can affect day-to-day usage, common tasks were put to the tests, tasks such as browsing, searching, emailing, instant messaging, social networking, consuming streaming content, and gaming. The results from the tests are interesting, websites that do not support HTTPS were exposed, apps that do not fully support HTTPS were also being uncovered. One surprisingly, and arguably pleasant, side effect was discovered – the filtering solution blocks out advertisements in all of the games being tested, hence contributing to an improved gaming experience.
A Study of Transient Voltage Peaking in Diode-Based ESD Protection Structures in 28nm CMOS (2020)

Transient voltage peaking under very fast electrostatic discharge (ESD), like charged device model (CDM) pulse, is a serious problem to integrated circuits (ICs). A combined TCAD simulation and very fast transmission line pulse (VFTLP) testing method is proposed to thoroughly investigate the transient voltage peaking phenomena of diode-based ESD protection structures under CDM stressing. The study of a set of diode, diode-string and diode-triggered silicon-controlled rectifier (DTSCR) ESD protection structures, fabricated in a 28nm CMOS process, reveals that the inductive impedance along the ESD discharging path may be the root cause of voltage peaking under CDM stressing. The observation provides the design insights overcoming the voltage peaking problem in ESD protection designs before complicate CDM package level testing.
Clinical Sociology and the Individual Client (1997)

Clinical sociology has a large, albeit under-appreciated, role to play in helping individual clients. The types of problems addressed by helping professionals can be classified in four major areas, namely physiological problems, moral problems, problems in living, and role problems. These are respectively best dealt with by medical, social control, problem-solving, and resocialization solutions. Clinical sociology can contribute to each of these owing to its expertise in social support, socialization, resocialization, emotional competence, and moral competence. As we approach the new millennium, it is remarkable mat the potential which sociology possesses for aiding individual clients who are troubled by personal problems has yet to be fully realized (Straus 1985). While psychology, medicine, and social work are solidly established, clinical sociology languishes in a backwater peopled chiefly by the sociological cognoscenti. The public has learned about the benefits of family therapy, art
Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory (1997)

Perinatal choline supplementation can improve performance on a variety of spatial memory tasks in adulthood. In order to extend these studies, we have investigated the effects of perinatal choline supplementation on the performance of a peak-interval timing task in which a 20 s temporal criterion was trained for a visual signal in adult (3-6 months old) rats. Following 5 weeks of baseline training, rats received systemic injections of nicotine (0.1, 0.2, or 0.4 mg/kg, s.c.) or saline prior to testing on the peak-interval timing task. The results indicated that perinatal choline supplementation increased rats' sensitivity to the 20 s temporal criterion during baseline training and facilitated the clock speed enhancing effects of nicotine during drug testing. The present study extends the types of long-term cognitive enhancement produced by perinatal choline supplementation to include the temporal processing domain and relates these effects to modifications in cholinergic function.