gebhart/patrepeval huggingface dataset:
Rational molecular design for realizing high performance sky-blue-emitting gold(<scp>iii</scp>) complexes with monoaryl auxiliary ligands and their applications for both solution-processable and vacuum-deposited organic light-emitting devices (2018)

A new class of sky-blue-emitting arylgold(iii) complexes containing tridentate bis-cyclometalating ligands derived from 2,6-diphenylpyridine (C^N^C) has been successfully designed and synthesized. By systematically varying the electron-withdrawing groups from cyano, fluoro, and trifluoromethyl to trifluoromethoxy groups on the phenyl ring of the tridentate C^N^C ligands, the emission maxima of these complexes have been significantly blue-shifted from 492 nm to 466 nm in dichloromethane solution. In addition, the higher excited state distortion with respect to the ground state associated with the multiple fluoro substitutions at the tridentate ligand has been successfully reduced by the employment of trifluoromethyl and trifluoromethoxy groups, as revealed by the Huang-Rhys factor. Taking advantage of their high photoluminescence quantum yields of up to 43% in the solid-state MCP thin-films, high performance solution-processable and vacuum-deposited organic light-emitting devices with external quantum efficiencies of up to 5.3% and 11.3%, respectively, have been realized. This work represents the first demonstration of sky-blue-emitting gold(iii) complexes with an <i>x</i> chromaticity coordinate of <0.2.
Flying-Adder Fractional Divider Based Integer-N PLL: 2nd Generation FAPLL as On-Chip Frequency Generator for SoC (2012)

Flying-Adder direct period synthesis is a technology that directly constructs output clock period from a known base time unit Δ. In the past, it is mainly used for driving digital load. In this work, a new scheme is proposed to produce spectrally pure clock signal at certain frequencies which can be used to drive devices such as SoC on-chip ADC, DAC and etc. This scheme utilizes a Flying-Adder synthesizer as a fractional divider placed inside the PLL loop. Additionally, a PDFR technique is used to help improve the frequency resolution. Moreover, a unique accumulator is used to boost circuit speed. A 55 nm implementation is fabricated and is used to validate the architecture of this 2nd generation Flying-Adder PLL. The resolution of this enhanced integer-N PLL is 1.5 MHz across the entire VCO operating range with a 12 MHz input and loop bandwidth of 1 MHz. The power consumed is 8.3 mW at 2.3 GHz and the area is 0.16 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The significance of this fractional divider is discussed at the end. A brief comparison between this clock generator and others is given at the end as well.
A novel graph-based soft interference cancellation algorithm for FDM-CPM satellite systems (2009)

We consider a frequency division multiplexed (FDM) satellite system where each user employs a continuous phase modulation (CPM), serially concatenated with an outer code through an interleaver, and iterative detection/decoding. In such a system, the spectral efficiency can be increased by reducing the spacing between two adjacent channels, thus increasing the relevant interference. Hence, we address the design of low-complexity suboptimal multiuser detectors able to effectively cope with such an interference. We extend some well known multiuser detection algorithms proposed for code division multiple access (CDMA) systems. Moreover, we introduce a new detection scheme using the framework based on factor graphs (FGs) and the sum-product algorithm (SPA). The simulation results show that the described algorithms allow to effectively reduce the spacing, thus increasing the spectral efficiency, and in particular, the proposed detection scheme results to be the most effective one in terms of performance and computational complexity.
Intermodulation Read-Out Principle for Passive Wireless Sensors (2011)

This paper presents a general intermodulation read-out principle for passive wireless sensors. A sensor utilizes a mixing element, such as a varactor, and it can be equipped with a capacitive, inductive, or resistive sensor element. When the sensor is illuminated with signals with two frequencies, it replies the sensor data at an intermodulation frequency. An analytical expression for the intermodulation response of the sensor is derived and verified by simulations. The concept is demonstrated at 1.2 GHz.
Electrochemical sensors based on DNA-mediated charge transport chemistry (2003)

The base pair stack within double helical DNA provides an effective medium for charge transport. The -stacked DNA base pairs mediate charge transport chemistry over long molecular distances in a reaction that is exquisitely sensitive to DNA sequence-dependent conformation and dynamics. This sensitivity to minor perturbations in DNA structure and base stacking makes DNA-mediated charge transport chemistry an ideal platform for DNA sensing. Electrochemical methods through DNA-modified electrode surfaces that exploit this sensitivity for efficient biosensing are described. Gold electrodes are modified with DNA double helices and used to monitor the electrochemistry of bound redox-active intercalators. The efficiency of electrochemical reduction of the intercalated redox-probe, in a DNA-mediated reaction, provides an indicator of base stacking within the surface-bound duplexes. Perfectly stacked DNA is capable of mediating the electrochemical reduction, while duplexes containing [pi]-stacking perturbations, such as single base mismatches, do not support current flow to the intercalator. 

All single base mismatches, including thermodynamically stable GT and GA mismatches, as well as many common base damage products can be detected within DNA and DNA/RNA hybrid duplexes using this assay. Moreover, mismatches can be detected as a small percentage of a perfectly matched film, making it possible to detect mutations associated with genetic disorders in only a small fraction of cells. This assay is also compatible with DNA based chip technology. Furthermore, electrochemistry at DNA films is found to provide a novel and sensitive method for probing protein dependent changes in DNA structure and enzymatic reactions. 

The efficient transport of charge through self-assembled monolayers of thiol-terminated duplexes on gold therefore offers an extremely sensitive probe for the integrity of DNA sequences. Completely new approaches to single base mismatch detection as well as assaying protein-DNA interactions and reactions on surfaces are now available. This technology is generally applicable as a tool for directly measuring base pair stacking in nucleic acid duplexes.
Real time two‐photon absorption microscopy using multi point excitation (1998)

In this communication we present the development of a real time two‐photon absorption microscope, based on parallel excitation with many foci. This pattern of foci is created by a two‐dimensional microlens array. The fluorescence is detected by direct, non descanned detection on a CCD camera. Due to the parallel nature of both excitation and detection it is possible to speed up image acquisition significantly. This makes the instrument especially suitable for studying living specimens and/or real time processes. The optical design of the instrument is discussed and an imaging example is given. We specifically address the relation between the axial sectioning capability and the distance between the illumination foci at the sample.
Mapping dopamine transporters in the human brain with novel selective cocaine analog [<sup>125</sup>I]RTI‐121 (1995)

The novel cocaine analog RTI-121 [3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester] was evaluated as a probe for the in vitro labeling and localization of the dopamine transporter in the human brain. Saturation binding experiments conducted in sucrose-phosphate buffer (10 mM sodium phosphate, pH 7.4, 0.32 M sucrose) revealed high- and low-affinity binding components with affinity values (KD) of 0.25 +/- 0.04 and 4.9 +/- 1.6 nM (mean +/- SE) and densities (Bmax) of 56.8 +/- 13.8 and 147.7 +/- 23.4 pmol/g tissue, respectively. In contrast, when saturation binding experiments were performed in phosphate-buffered saline (10 mM Na2HPO4, 1.8 mM KH2PO4, 136 mM NaCl, 2.8 mM KCl, 10 mM NaI, pH 7.4), a 9-fold decrease in the density of the low-affinity component was noted, suggesting that the low-affinity RTI-121 binding site is associated with the region of the transporter involved in the ionic dependence of substrate recognition and/or uptake. The rank order of potency for inhibition of [125I]RTI-121 binding to human caudate membranes demonstrates that the radioligand selectively labels the dopamine transporter (GBR 12909 > RTI-121 > mazindol > nomifensine > (-) cocaine > desipramine > citalopram). Autoradiographic mapping of [125I]RTI-121 revealed very high densities of cocaine recognition sites over areas known to be rich in dopaminergic innervation, including the caudate, putamen, and nucleus accumbens. Moderate densities were also observed over the substantia nigra and the ventral tegmental area. Low-to-background labeling of [125]RTI-121 was seen throughout the cerebral cortex, amygdaloid nuclei, globus pallidus, and thalamus. In comparison with the autoradiographic distribution of the cocaine analogs [3H]WIN 35,428 (or CFT) and [125I]RTI-55 (or beta-CIT), the labeling pattern for [125I]RTI-121 was more restricted. These studies demonstrate that [125I]RTI-121 labels dopamine-rich brain regions with greater selectivity than other currently available cocaine analogs, which makes it a potentially superior imaging probe for mapping the dopamine transporter in the human brain.
Isolation of tumor-secreted products from human carcinoma cells maintained in a defined protein-free medium. (1985)

A protein-free synthetic cell-growth medium has been defined that permits long-term survival (greater than 120 days) of an established human colon tumor cell line, HT-29. Viability is dependent upon both the concentration of L-glutamine in the medium and the cell density at the time of initial transfer into it. Cell proliferation is minimal, thus obviating the necessity for subculturing. HT-29 adenocarcinoma cells maintained in large-scale culture with this medium continue to secrete the established colon tumor marker carcinoembryonic antigen as well as growth factors and lysozyme. These and, potentially, other important tumor-derived products can therefore be generated continuously in such cultures so that they can be isolated from a conditioned medium free of contaminating serum and protein supplements.
Experimental demonstration of Raman-assisted phase sensitive amplifier with negligible gain/power fluctuation (2015)

We first demonstrated a Raman-assisted phase sensitive amplifier, which has no optical fiber path separation between pump and signal to achieve negligible power fluctuation. Better noise performance of the proposed scheme was verified with BER measurements as comparing to EDFA.
MEF: Malicious Email Filter: A UNIX Mail Filter that Detects Malicious Windows Executables (2001)

We present Malicious Email Filter, MEF, a freely distributed malicious binary filter incorporated into Procmail that can detect malicious Windows attachments by integrating with a UNIX mail server. The system has three capabilities: detection of known and unknown malicious attachments, tracking the propagation of malicious attachments and efficient model update algorithms. The system filters multiple malicious attachments in an email by using detection models obtained from data mining over known malicious attachments. It leverages preliminary research in data mining applied to malicious executables which allows the detection of previously unseen, malicious attachments. In addition, the system provides a method for monitoring and measurement of the spread of malicious attachments. Finally, the system also allows for the efficient propagation of detection models from a central server. These updated models can be downloaded by a system administrator and easily incorporated into the current model. The system will be released under GPL in June 2001.
A Tree‐Based Approach to Proficiency Scaling and Diagnostic Assessment (1997)

A new procedure for generating instructionally relevant diagnostic feedback is proposed. The approach involves first constructing a strong model of student proficiency and then testing whether individual students’ observed item response vectors are consistent with that model. Diagnoses are specified in terms of the combinations of skills needed to score at increasingly higher levels on a test's reported score scale. The approach is applied to the problem of developing diagnostic feedback for the SAT I Verbal Reasoning test. Using a variation of Wright's (1977) person‐fit statistic, it is shown that the estimated proficiency mode accounts for 91% of the “explainable” variation in students’ observed item response vectors.
T-cell signaling pathways inhibited by the tick saliva immunosuppressor, Salp15 (2007)

The Ixodes scapularis salivary protein Salp15 inhibits the activation of T cells through its interaction with the coreceptor CD4. Salp15 prevents the activation of Lck upon TCR engagement and the formation of lipid rafts. We have now analyzed the signaling pathways that are inhibited by the tick salivary protein in CD4(+) T cells. Salp15 affects tyrosine phosphorylation of several early signal components downstream of Lck, including LAT and Vav1, which results in improper actin polymerization. The effect of Salp15 is due to its interaction with CD4, as no effect was observed in CD4-negative T cells. Finally, we demonstrate that the peptide that mediates the interaction of Salp15 with CD4, P11, is able to recapitulate the immunosuppressive activity of the whole protein. These results clarify the molecular mechanisms of action of Salp15 on T cells and suggest that binding to CD4 is sufficient to elicit its immunosuppressive effect.
PHASE SENSITIVE X-RAY IMAGING: TOWARDS ITS INTERDISCIPLINARY APPLICATIONS (2010)

X‐ray phase imaging including phase tomography has been attracting increasing attention during the past few decades. The advantage of X‐ray phase imaging is that an extremely high sensitivity is achieved for weakly absorbing materials, such as biological soft tissues, which generate a poor contrast by conventional schemes. Especially for such living samples, where the reduction of the applied dose is of paramount interest, phase sensitive measurements schemes have an inherent potential for a significant dose reduction combined with an image quality enhancement. Several methods have been invented for x‐ray phase contrast imaging that either use an approach based on interferometry, diffraction or wave‐field propagation. Some of these techniques have a potential for commercial applications, such as in medicine, non‐destructive testing, security and inspection. The scope of this manuscript thus deals with one particular such technique that measures the diffraction caused by the specimen by means of a grating interferometer. Examples of measurements are shown that depict the potential of phase contrast imaging for future commercial applications, such as in medical imaging, non‐destructive testing and inspection for quality control. The current state of the technology is briefly reviewed as well as its shortcomings to be overcome with regard to the applications.
<title>Protein database searching with MS<formula><sup><roman>n</roman></sup></formula> spectra of polypeptides</title> (1996)

Database searching with tandem mass spectra has been demonstrated as a powerful method to correlate peptides and proteins to gene sequences for identification. In this study preliminary data is shown for extending the cross-correlation database searching method to multi-stage mass spectra of polypeptides. This method may provide a means to directly identify large polypeptides or proteins without the necessity of proteolytic hydrolysis to produce peptides amenable to tandem mass spectrometry.
Fluoride-free Synthesis of Germanosilicate CIT-13 and Its Inverse Sigma Transformation To Form CIT-14 (2020)

Germanium-containing, extra-large pore molecular sieve CIT-13 is synthesized without the use of fluoride. After the removal of occluded organics, CIT-13 obtained from fluoride-free preparation shows significant differences from CIT-13 samples prepared in the presence of fluoride. CIT-13 prepared using a fluoride-free method is able to undergo inverse sigma transformation to yield CIT-14 and transforms into a CIT-5-type germanosilicate much faster than Ge-CIT-13 of similar Si/Ge ratios from a fluoride-containing synthesis. A Rietveld-refined structure solution for CIT-14 reveals that this new molecular sieve possesses 12- and 8-membered ring channels. Results from 19F magic-angle spinning (MAS) and 1H–29Si cross-polarized MAS nuclear magnetic resonance spectroscopy reveal that CIT-13 crystallized without fluoride has germanium siting which is different from CIT-13 synthesized in the presence of fluoride.
Effect of dietary protein quality and essential fatty acids on fatty acid composition in the liver and adipose tissue after rapid weight loss in overweight cats (2003)

These data provide direct evidence that dietary protein quality alters fatty acid composition of tissues during weight loss in cats. The fatty acid patterns observed suggest that protein quality may alter fatty acid composition through modulation of desaturase activity.
Automatic localization of three-dimensional cephalometric landmarks on CBCT images by extracting symmetry features of the skull (2017)

To propose an algorithm for automatic localization of 3D cephalometric landmarks on CBCT data, those are useful for both cephalometric and upper airway volumetric analysis. 20 landmarks were targeted for automatic detection, of which 12 landmarks exist on the mid-sagittal plane. Automatic detection of mid-sagittal plane from the volume is a challenging task. Mid-sagittal plane is detected by extraction of statistical parameters of the symmetrical features of the skull. The mid-sagittal plane is partitioned into four quadrants based on the boundary definitions extracted from the human anatomy. Template matching algorithm is applied on the mid-sagittal plane to identify the region of interest ROI, further the edge features are extracted, to form contours in the individual regions. The landmarks are automatically localized by using the extracted knowledge of anatomical definitions of the landmarks. The overall mean error for detection of 20 landmarks was 1.88 mm with a standard deviation of 1.10 mm. The cephalometric land marks on CBCT data were detected automatically with in the mean error less than 2 mm.
The thermal characteristics of different intumescent coatings (1999)

Intumescent coatings are among the most efficient ways of fire retarding flammable materials. The coatings swell under the influence of heat and form a thick porous charred layer. The latter perfectly insulates the substrate against an excessive increase of temperature and oxygen access. In order to make intumescent coatings effective, proper selection of the essential components, i.e. carbonizing, foam-producing and dehydrating materials, is necessary. The choice of components for an intumescent fire retardant composition has an essential effect on the rate of charred mass formation and its structure. The influence of different modifiers added to amino resins during the process of condensation on fire retardant and heat-insulating efficiency of intumescent coatings for wood is presented. The fireproofing efficiency was studied by determining the heat release rate, the effective heat of combustion, the mass loss rate and the specific extinction area during the combustion of samples was investigated. The most efficient coating, both from the point of view of fire retardancy and heat insulating properties, was found to be that based on amino resin prepared from urea, dicyandiamide and monoammonium phosphate and dextrin. The exposing of wood coated with urea-dicyandiamide-phosphate-formaldehyde resin supplemented by dextrin to a heat flux of 35 kW/m2 for 30 min did not result in ignition and no increase occured in heat release, mass loss rates or in effective heat of combustion. Copyright © 1999 John Wiley & Sons, Ltd.
5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluationH. D. Hollis Showalter, Judith L. Johnson, Leslie M. Werbel, Wilbur R. Leopold, Robert C. Jackson, and Edward F. ElslagerCite this: J. Med. Chem. 1984, 27, 3, 253–255Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/jm00369a002https://doi.org/10.1021/jm00369a002research-articleACS PublicationsRequest reuse permissionsArticle Views200Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Random UV-C mutagenesis of<i>Scheffersomyces</i>(formerly<i>Pichia</i>)<i>stipitis</i>NRRL Y-7124 to improve anaerobic growth on lignocellulosic sugars (2011)

Scheffersomyces (formerly Pichia) stipitis NRRL Y-7124 was mutagenized using UV-C irradiation to produce yeast strains for anaerobic conversion of lignocellulosic sugars to ethanol. UV-C irradiation potentially produces large numbers of random mutations broadly and uniformly over the whole genome to generate unique strains. Wild-type cultures of S. stipitis NRRL Y-7124 were subjected to UV-C (234 nm) irradiation targeted at approximately 40% cell survival. When surviving cells were selected in sufficient numbers via automated plating strategies and cultured anaerobically on xylose medium for 5 months at 28°C, five novel mutagenized S. stipitis strains were obtained. Variable number tandem repeat analysis revealed that mutations had occurred in the genome, which may have produced genes that allowed the anaerobic utilization of xylose. The mutagenized strains were capable of growing anaerobically on xylose/glucose substrate with higher ethanol production during 250- to 500-h growth than a Saccharomyces cerevisiae yeast strain that is the standard for industrial fuel ethanol production. The S. stipitis strains resulting from this intense multigene mutagenesis strategy have potential application in industrial fuel ethanol production from lignocellulosic hydrolysates.