gebhart/patrepeval huggingface dataset:
Interim analysis of a phase I study of INCB040093, a PI3Kδ inhibitor, alone or in combination with INCB039110, a selective JAK1 inhibitor, in patients (pts) with relapsed or refractory (r/r) B-cell malignancies. (2015)

8520 Background: Inhibiting the PI3K or JAK-STAT pathways may be therapeutic in B-cell malignancies due to their contribution to tumor growth and survival and effects on the tumor microenvironment. Blocking both pathways may be synergistic due to JAK-STAT augmentation of BCR activation of the NFκB pathway. Methods: This ongoing dose escalation study with expansion cohorts enrolled adult pts with r/r B-cell malignancies. INCB040093 was given at doses between 100–300 mg QD or BID alone or 150–300 mg QD or BID with INCB039110 at 400–600 mg QD. Safety, efficacy, and pharmacodynamics were evaluated. Results: A total of 83 pts have been enrolled: FL n = 19; cHL n = 17; DLBCL n = 15; CLL/SLL n = 13; others n = 19. Median age was 61 years and 70% were men. The median number of prior regimens was 4 and 24% underwent HSCT. Median exposure was 185 days (range: 5 – 491+ [ongoing]) for INCB040093 alone and 99 days (range: 6 – 337+ [ongoing]) for INCB040093 + INCB039110. The most common AEs were fatigue (28%), headache (19%), pyrexia (19%) and the most common grade ≥ 3 AE was pneumonia (6%). The most common laboratory abnormalities were liver enzyme elevations and cytopenias. One pt had a DLT on INCB040093 100 mg BID (GI bleed secondary to gastric DLBCL regression). Doses of INCB040093 100 mg BID and INCB040093 100 mg BID + INCB039110 400 mg QD were selected for expansion cohorts based on the incidence of liver enzyme elevations with INCB040093 and cytopenias with INCB040093 + INCB039110 at higher doses. At the selected doses, pAKT was decreased by ~90% at trough on INCB040093 and IL6-induced pSTAT3 was decreased an average of 65% on INCB039110. Of 75 pts thus far evaluated for a response, 28 responses have been reported. Notably, ORR was 60% (3 CRs) for r/r cHL and both pts with the non-GCB subtype of DLBCL had CRs. Conclusions: Treatment with INCB040093 ± INCB039110 was tolerable and produced responses, including CRs, in pts with heavily pretreated r/r B-cell malignancies. Given this activity, the study was expanded to enroll additional cohorts of pts with r/r B-cell malignancies such as DLBCL and cHL, and a phase II study in pts with r/r cHL was initiated. Clinical trial information: NCT01905813.
Drift tube soft-landing for the production and characterization of materials: Applied to Cu clusters (2010)

We have recently developed a soft-landing (SL) instrument that is capable of depositing ions onto substrates for preparative and developmental research of new materials using a laser ablation source. This instrument was designed with a custom drift tube and a split-ring ion optic for the isolation of selected ions. The drift tube allows for the separation and thermalization of ions formed after laser ablation through collisions with an inert bath gas. These collisions allow the ions to be landed at energies below 1 eV onto substrates. The split-ring ion optic is capable of directing ions toward the detector or a landing substrate for selected components. Experiments will be shown ablating Cu using an Nd:YAG (1064 and 532 nm) for cluster formation and landing onto a muscovite (mica) surface. The laser ablation of Cu in 8 Torr of He gas gives a spectrum that contains multiple peaks corresponding to Cu(n), Cu(n)O(m) clusters, and their corresponding isomers. Atomic force microscopy and drift tube measurements were performed to characterize the performance characteristics of the instrument.
Tunable Infrared Devices via Ferroelectrics: Tunable Infrared Devices via Ferroelectric Domain Reconfiguration (Advanced Optical Materials 24/2018) (2018)

Ferroelectric bilayers are leveraged in concert with a metasurface to create tunable infrared devices possessing high-speed, low-power and latchable switching (see article number 1800862 by Thomas E. Beechem and co-workers). Together, these characteristics highlight the potential of ferroelectrics for dynamic infrared elements while also emphasizing the general utility of leveraging phonons to sculpt a material's infrared response.
Assessing the changes in the spatial stiffness of the posterior sclera as a function of IOP with air-pulse OCE (2017)

The mechanophysiology of tissues in the posterior eye have been implicated for diseases such as myopia and glaucoma. For example, the eye-globe shape, and consequently optical axial length, can be affected by scleral stiffness. In glaucoma, an elevated intraocular pressure is the primary risk factor for glaucoma, which is the 2nd most prevalent known cause of blindness. Recent work has shown that biomechanical properties of the optic nerve are critical for the onset and progression of glaucoma because weak tissues cause large displacements in the optic nerve, causing tissue damage. In this work, we utilize air-pulse optical coherence elastography (OCE) to quantify the spatial distribution of biomechanical properties of the optic nerve, its surrounding tissues, and the posterior sclera. Air-pulse measurements were made in a grid on in situ porcine eyes in the whole eye-globe configuration as various IOPs. The OCE-measured displacement process was linked to tissue stiffness by a simple kinematic equation. The results show that the optic nerve and peripapillary sclera are much stiffer than the surrounding sclera, and the stiffness of the optic nerve and peripapillary sclera increased as a function of IOP. However, the stiffness of the surrounding sclera did not dramatically increase. Our results show that understanding the dynamics of the biomechanical properties of the eye are critical to understand the aforementioned diseases and may provide additional information for assessing visual health and integrity.
A Method to Optimize the Output Power of MEMS Vibrational Energy Harvester (2021)

A MEMS vibrational energy harvester is developed as a power source for infrastructures monitoring systems. The output power is maximized by appropriately choosing the load resistance in accordance with the vibration conditions of the vibration source. Output power of more than 500 µW is obtained from the vibrations caused by a vacuum pump used in a factory.
New, Potent, and Selective Peptidic Oxytocin Receptor Agonists (2014)

Mothers of preterm babies frequently have difficulty establishing or maintaining lactation, thought to be due to interference with the milk ejection reflex. Administration of exogenous oxytocin can produce alveolar contraction and adequate breast emptying resulting in establishment of successful lactation. The natural hormone oxytocin is not receptor-selective and may cause hyponatremia via V2 receptor mediated antidiuresis. We have designed a series of potent oxytocin analogues containing N-alkylglycines in position 7 with excellent selectivity versus the related V1a, V1b, and V2 vasopressin receptors and short half-life: agonists 31 ([2-ThiMeGly(7)]dOT), 47 (carba-6-[Phe(2),BuGly(7)]dOT), 55 (carba-6-[3-MeBzlGly(7)]dOT), and 57 (carba-1-[4-FBzlGly(7)]dOT) have EC50 values at hOTR < 0.1 nM, selectivity ratios versus related human vasopressin receptors of >2000, IC50 at hV1aR > 500 nM, and total clearance in rats in the range of 60-80 mL min(-1) kg(-1). Compound 57 (FE 202767) is currently in clinical development for the treatment of preterm mothers requiring lactation support.
Synthesis, activity and structure–activity relationship of noroviral protease inhibitors (2013)

The protease of norovirus, an important human pathogen, is essential for the viral replication and, therefore, represents a potential drug target. A series of tripeptide-based inhibitors of the protease were designed, synthesized and tested, among which several potent inhibitors were identified with K<sub>i</sub> values as low as 75 nM. The structure-activity relationships of these inhibitors are discussed.
Novel lipid compounds and compositions containing same used for the transfer of at least an active substance, in particular.. (1999)

The present invention relates to lipid compounds of formula I, wherein said compounds are optionally in a cationic form and are optionally combined with one or more biologically acceptable anions. The present invention also relates to complexes..
A scalable approach to building a parallel corpus from the web (2011)

Parallel text acquisition from the Web is an attractive way for augmenting statistical models (e.g., machine translation, crosslingual document retrieval) with domain representative data. The basis for obtaining such data is a collection of pairs of bilingual Web sites or pages. In this work, we propose a crawling strategy that locates bilingual Web sites by constraining the visitation policy of the crawler to the graph neighborhood of bilingual sites on the Web. Subsequently, we use a novel recursive mining technique that recursively extracts text and links from the collection of bilingual Web sites obtained from the crawling. Our method does not suffer from the computationally prohibitive combinatorial matching typically used in previous work that uses document retrieval techniques to match a collection of bilingual webpages. We demonstrate the efficacy of our approach in the context of machine translation in the tourism and hospitality domain. The parallel text obtained using our novel crawling strategy results in a relative improvement of 21% in BLEU score (English-to-Spanish) over an out-of-domain seed translation model trained on the European parliamentary proceedings.
Flip chip assembly with sub-micron 3D re-alignment via solder surface tension (2015)

We demonstrate experimentally a flip-chip assembly with submicron three-dimensional alignment accuracy. We employ solder surface tension to push the flipped chip into lithographically defined alignment stops. During reflow, surface tension forces of the melted solder can move a chip by more than a hundred microns. We use these motions to obtain self-alignment by constraining the motions to lithographically defined mechanical stops and chip edge butting. This approach is particularly useful in InP laser to Si photonic assemblies, where sub-micron alignment is required for low optical connection loss. In this report, our test vehicles comprise silicon photonic chips and laser placeholder chips made of silicon as well. To enable self-alignment of edge-emitting single-mode lasers, a significant re-alignment range is needed to overcome the laser cleaving tolerance of +/- 15 microns and the low +/- 10 microns placement accuracy of high-throughput pick-and-place tools. We employ in-situ infrared (IR) microscopy to look through the assembled chips during solder induced re-alignment. We show that the self-alignment of the chips starts at the moment the solders melt. Cross sectional analysis is used to confirm the alignment accuracy and contact on the lithographic stops. We discuss process window considerations related to standoff height and solder volume.
Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma (2016)

Alternatively spliced Tissue Factor (asTF) is a secreted form of Tissue Factor (TF), the trigger of blood coagulation whose expression levels are heightened in several forms of solid cancer, including pancreatic ductal adenocarcinoma (PDAC). asTF binds to β1 integrins on PDAC cells, whereby it promotes tumor growth, metastatic spread, and monocyte recruitment to the stroma. In this study, we determined if targeting asTF in PDAC would significantly impact tumor progression. We here report that a novel inhibitory anti-asTF monoclonal antibody curtails experimental PDAC progression. Moreover, we show that tumor-derived asTF is able to promote PDAC primary growth and spread during early as well as later stages of the disease. This raises the likelihood that asTF may comprise a viable target in early- and late-stage PDAC. In addition, we show that TF expressed by host cells plays a significant role in PDAC spread. Together, our data demonstrate that targeting asTF in PDAC is a novel strategy to stem PDAC progression and spread.
Unforeseen Applications of Rydberg Atom-Based Sensors: SI Traceability, Phase Detection, Musical Recording, and other Unique Applications (2020)

Great progress had been made in the use of Rydberg atoms to detect the amplitude, phase, and polarization of electric fields and modulated signals. This has led to several unforeseen applications, which are discussed here.
Terahertz difference frequency generation in quantum cascade lasers (2007)

We demonstrate intra-cavity terahertz difference-frequency generation in quantum cascade lasers. A two-wavelength quantum cascade laser with monolithically integrated optical nonlinearity emitting at 7.6 and 8.7 μm was used to generate difference frequency at 62 μm.
Measuring People-Flow through Doorways Using Easy-to-Install IR Array Sensors (2017)

People counting has many applications in smart buildings. For example, adjusting HVAC systems based on the number of occupants in each room can save a significant amount of energy. In addition, security and safety of the building can be managed by determining the number and location of occupants. Different technologies and sensing platforms have proposed for accurate and efficient people counting. However, these solutions are expensive, hard to deploy, or privacy invasive. We investigate the possibility of placing an 8×8 IR array sensor at the doorways and counting the number of people inside rooms. Our solution is real-time, inexpensive, privacy preserving with much less deployment constraints compared to its competitors. The proposed solution deals with realistic and dynamic changes in the sensing environment by leveraging a combination of Otsus thresholding and modeling thermal noise distribution. We evaluated our solution via several controlled and uncontrolled real-world environments. The results show an average of 93% accuracy in estimating the number of occupants in rooms.
Steroid 5α-Reductase Isozymes I and II in Recurrent Prostate Cancer (2005)

Expression levels and isozyme activity shifts from S5alphaRII toward S5alphaRI in recurrent prostate cancer. Dual inhibition of S5alphaRI and S5alphaRII should reduce dihydrotestosterone biosynthesis and may prevent or delay growth of recurrent prostate cancer.
VBR MPEG video coding with dynamic bandwidth renegotiation (2002)

A scheme for VBR video coding is proposed where encoding bandwidth can be renegotiated between the encoder and the network during the duration of a call. Renegotiation can be initiated by either the encoder or the network. The encoder's bandwidth requirement is characterized by a usage parameter control (UPC) set consisting of peak rate, burst length and sustained rate. An adaptive encoder rate-control algorithm at the network interface card (NIC) computes the necessary UPC parameters to maintain the user specified quality-of-service (QoS). The network may, optionally, set a lower UPC value to deal with congestion. Simulation results are given for a rate-controlled VBR video encoder operating through an ATM network interface which supports dynamic UPC. These results suggest that dynamic band-width renegotiation could provide significant quality gains and/or bandwidth savings with graceful degradation during renegotiation transients, even in the presence of relatively large feedback delay.
Poly(ethylene terephthalate) melt spinning via controlled threadline dynamics (1992)

Abstract Fiber melt spinning of poly(ethylene terephthalate) (PET) was studied via modification of threadline dynamics. Several techniques were implemented in the high‐speed spinning process for the judicious control of threadline dynamics. This included a thermal conditioning zone (TCZ) for controlling the threadline temperature profile and a dydraulic drag bath (HDB) for controlling the threadline spinning stress. Through controlled threadline dynamics, key factors affecting the structure development—namely, temperature, tensile stress, and crystallization time—were manipulated to favor formation of a highly oriented and transversely uniform structure in the spun fibers. This carries the implication that optimum or near‐optimum processing conditions are being applied during the structure development period. More specifically, tensile stress in the threadline, independent of temperature, is substantially increased to many orders higher than that ordinarily attained in the normal high‐speed spinning process. Concurrently, the temperature crucial to the structure development is being independently optimized and its duration extended to attain a highly oriented structural order. Properties of the spun fibers were found to be correlated with the threadline parameters including cooling profile, tension profile, and strain rate. PET fibers spun via the one‐step process with the introduction of the TCZ and HDB possess superior mechanical performance. Structural characterization suggests that the spun fibers have a high amorphous orientation factor and a uniform radial structure distribution. Further on‐line studies indicate that structure development in the threadline is completely different from that of the traditional high‐speed spinning process. The attenuation profile of the threadline is observed to be dependent of TCZ temperature, residence time in the HDB, temperature of the HDB, and take‐up speed. It is believed that for the melt spinning process with the TCZ and the HDB, the threadline dynamics is changed from one controlled by inertia and air drag forces to one controlled by the imposed hydraulic drag.
ChemInform Abstract: Beyond Post‐Synthesis Modification: Evolution of Metal—Organic Frameworks via Building Block Replacement (2014)

Abstract Review: 132 refs.
SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG (2017)

Nearly 50% of prostate cancers harbor gene fusions that lead to overexpression of the transcription factor ERG, while a mutually exclusive 10% of prostate cancers harbor recurrent mutations in the gene encoding the E3 ubiquitin ligase SPOP. Recent reports suggest that SPOP acts as a ubiquitin ligase for ERG and propose that ERG stabilization is the oncogenic effector of SPOP mutation. Here, we used human prostate cancer samples and showed that the vast majority of human SPOP-mutant cancers do not express ERG. Comparison of SPOP-mutant and ERG-fusion organoid models showed evidence of divergent, rather than common, transcriptional programs. Furthermore, expression of prostate cancer-associated SPOP mutations in genetically engineered mouse models of SPOP-mutant prostate cancer did not result in the expression of ERG protein in histologically normal prostate glands, high-grade prostatic intraepithelial neoplasia, invasive adenocarcinoma, or prostate organoids. In summary, we found no evidence that ERG is an effector of SPOP mutation in human prostate cancer or mouse models.
A Novel Laser-Induced Photothermal Displacement Spectroscopy (LIPDS) for Detection and Speciation of a Metal Ion in Aqueous Solution (1997)

KEYWORDS: laser-induced photothermal displacement spectroscopyoptical heterodyne interferometersdetectionspeciationchemical state metal ionsaqueous solutionsactinideslanthanidessensitivityremote handling
Sequential Bayesian Bit Error Rate Measurement (2004)

As bit error rates decrease, the time required to measure a bit error rate (BER) or perform a BER test (i.e., to determine that a particular communications device's BER is less than some acceptable limit) increases dramatically. One cause of long measurement times is the difficulty of deciding a priori how many bits to measure to establish the BER to within a predetermined confidence interval width. This paper explores a new approach to deciding how many bits to measure, namely a sequential Bayesian approach. As measurement proceeds, the posterior distribution of BER is checked to see if the conclusion can be made that the BER rate is known to be within the desired range with high enough probability. Desired properties of the posterior distribution such as the maximum a postiori estimate and confidence limits can be computed quickly using off-the-shelf numerical software. Examples are given of using this method on bit error data measured with an Agilent 81250 parallel BER tester.
Alkaline-side extraction of technetium from tank waste using crown ethers and other extractants (1996)

The chemical development of a new crown-ether-based solvent-extraction process for the separation of (Tc) from alkaline tank-waste supernate is ready for counter-current testing. The process addresses a priority need in the proposed cleanup of Hanford and other tank wastes. This need has arisen from concerns due to the volatility of Tc during vitrification, as well as {sup 99}Tc`s long half-life and environmental mobility. The new process offers several key advantages that direct treatability--no adjustment of the waste composition is needed; economical stripping with water; high efficiency--few stages needed; non-RCRA chemicals--no generation of hazardous or mixed wastes; co-extraction of {sup 90}Sr; and optional concentration on a resin. A key concept advanced in this work entails the use of tandem techniques: solvent extraction offers high selectivity, while a subsequent column sorption process on the aqueous stripping solution serves to greatly concentrate the Tc. Optionally, the stripping solution can be evaporated to a small volume. Batch tests of the solvent-extraction and stripping components of the process have been conducted on actual melton Valley Storage Tank (MVST) waste as well as simulants of MVST and Hanford waste. The tandem process was demonstrated on MVST waste simulants using the three solvents that were selected the final candidates for the process. The solvents are 0.04 M bis-4,4{prime}(5{prime})[(tert-butyl)cyclohexano]-18-crown-6 (abbreviated di-t-BuCH18C6) in a 1:1 vol/vol blend of tributyl phosphate and Isopar{reg_sign} M (an isoparaffinic kerosene); 0.02 M di-t-BuCH18C6 in 2:1 vol/vol TBP/Isopar M and pure TBP. The process is now ready for counter-current testing on actual Hanford tank supernates.
Acquisition and visualization of 5D respiratory-resolved cardiac MRI (2012)

We image the heart during free breathing and explicitly resolve 3D volumetric information over both the cardiac and respiratory cycles to capture a 5D view of the heart. This 5D dataset can be displayed in a variety of ways to study disease states that exhibit variations in cardiac function with respect to respiration, such as pericardial tamponade/constriction and diastolic dysfunction.
Development of Reverse Dynamic Optimization Methodology for Optimal Powertrain Integration and Control Design (2008)

A reverse tractive road load demand model, dynamic optimization methodology, and Matlab®/Simulink® based tool are developed to address the challenge of matching the powertrain hardware and control strategy to specific vehicle attributes and driver applications for improved overall vehicle system efficiency. The reverse dynamic optimization methodology can be used to assess and develop transmission shift and lock-up control strategies, evaluate alternative powertrain hardware configurations, and establish design criteria. The advantages of the reverse dynamic optimization approach are demonstrated and key system integration concepts are revealed by performing vehicle attribute, engine, transmission, and axle sensitivity analyses.