gebhart/patrepeval huggingface dataset:
<title>Brillouin fiber optic gyro with push-pull phase modulator and synthetic heterodyne detection</title> (1993)

Intracavity phase modulation in a fiber-optic ring laser gyro can provide 'optical dithering' to reduce the effects of frequency locking while retaining optical reciprocity in the cavity. We show that the use of two antiphased phase modulators placed symmetrically within the fiber cavity can provide uniformly distributed dithering. A modulation index of 2.4 theoretically eliminates the zero-order lock-in band around zero frequency, while use of a high modulation frequency puts higher-order lock-in bands outside the beat frequency dynamic range. Push-pull modulation allows for high modulation frequency with minimum dynamic perturbation of the cavity resonant behavior. We describe results with an experimental Brillouin fiber optic gyro operating at 1.3-micron wavelength using push-pull modulation together with a novel synthetic heterodyne detection scheme for sensing rotation rate and direction. A ten-fold reduction of the width of the zero-order lock-in band is observed. We also demonstrate that the observed frequency bias at zero rotation rate is caused by the Kerr effect due to the power imbalance between the two oppositely directed circulating lasers.
Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity (2023)

Genmab.
Transactions Papers Multiple-Rate Low-Density Parity-Check Codes with Constant Blocklength (2009)

This paper describes and analyzes low-density parity-check code families that support variety of different rates while maintaining the same fundamental decoder archi- tecture. Such families facilitate the decoding hardware design and implementation for applications that require communication at different rates, for example to adapt to changing channel conditions. Combining rows of the lowest-rate parity-check matrix produces the parity-check matrices for higher rates. An important advantage of this approach is that all effective code rates have the same blocklength. This approach is compatible with well known techniques that allow low-complexity encoding and parallel decoding of these LDPC codes. This technique also allows the design of programmable analog LDPC decoders. The proposed design method maintains good graphical properties and hence low error floors for all rates.
Time Reversal of Light with Linear Optics and Modulators (2004)

We introduce a new physical process that can perform a complete time-reversal operation on any electromagnetic pulse. The process uses only small refractive index modulations of linear optical elements. No nonlinear multiphoton effects such as four-wave mixing are required. The introduced process can be implemented on chip with standard semiconductor materials. Furthermore, the same process can be used to compress or expand the spectrum of electromagnetic waves while completely preserving the coherent information. We exhibit the time-reversal process by first-principles simulations of microcavity complexes in photonic crystals.
A deimmunised form of the ribotoxin, α-sarcin, lacking CD4<sup>+</sup>T cell epitopes and its use as an immunotoxin warhead (2016)

Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single phosphodiester bond in the sarcin-ricin loop of the large ribosomal subunit, thus making the ribosome unrecognisable to elongation factors and leading to inhibition of protein synthesis. Peptide mapping using an ex vivo human T cell assay determined that α-sarcin contained two T cell epitopes; one in the N-terminal 20 amino acids and the other in the C-terminal 20 amino acids. Various mutations were tested individually within each epitope and then in combination to isolate deimmunised α-sarcin variants that had the desired properties of silencing T cell epitopes and retention of the ability to inhibit protein synthesis (equivalent to wild-type, WT α-sarcin). A deimmunised variant (D9T/Q142T) demonstrated a complete lack of T cell activation in in vitro whole protein human T cell assays using peripheral blood mononuclear cells from donors with diverse HLA allotypes. Generation of an immunotoxin by fusion of the D9T/Q142T variant to a single-chain Fv targeting Her2 demonstrated potent cell killing equivalent to a fusion protein comprising the WT α-sarcin. These results represent the first fungal ribotoxin to be deimmunised with the potential to construct a new generation of deimmunised immunotoxin therapeutics.
Nanometrology optical ruler imaging system using diffraction from a quasiperiodic structure (2010)

This work demonstrates wafer-scale, path-independent, atomically-based long term-stable, position nanometrology. This nanometrology optical ruler imaging system uses the diffraction pattern of an atomically stabilized laser from a microfabricated quasiperiodic aperture array as a two-dimensional optical ruler. Nanometrology is accomplished by cross correlations of image samples of this optical ruler. The quasiperiodic structure generates spatially dense, sharp optical features. This work demonstrates new results showing positioning errors down to 17.2 nm over wafer scales and long term stability below 20 nm over six hours. This work also numerically demonstrates robustness of the optical ruler to variations in the microfabricated aperture array and discretization noise in imagers.
Challenges of corneal infections (2016)

Introduction: Ocular infections remain an important cause of blindness worldwide and represent a challenging public health concern. In this regard, microbial keratitis due to fungal, bacterial, or viral infection can result in significant vision loss secondary to corneal scarring or surface irregularity. Left untreated corneal perforation and endophthalmitis can result, leading to loss of the eye. Rigorously studied animal models of disease pathogenesis have provided novel information that suggests new modes of treatment that may be efficacious clinically and emerging clinical data is supportive of some of these discoveries.Areas covered: This review focuses on advances in our understanding of disease pathogenesis in animal models and clinical studies and how these relate to improved clinical treatment. We also discuss a novel approach to treatment of microbial keratitis due to infection with these bacterial pathogens using PACK-CXL and recommend increased basic and clinical studies to address and refine the efficacy of this procedure.Expert commentary: Because resistance to antibiotics has developed over time to these bacterial pathogens, caution must be exercised in treatment. Attractive novel modes of treatment that hold new promise for further investigation include lipid based therapy, as well as use of small molecules that bind deleterious specific host responsive molecules and use of microRNA based therapies.
EmoCo: Visual Analysis of Emotion Coherence in Presentation Videos (2019)

Emotions play a key role in human communication and public presentations. Human emotions are usually expressed through multiple modalities. Therefore, exploring multimodal emotions and their coherence is of great value for understanding emotional expressions in presentations and improving presentation skills. However, manually watching and studying presentation videos is often tedious and time-consuming. There is a lack of tool support to help conduct an efficient and in-depth multi-level analysis. Thus, in this paper, we introduce EmoCo, an interactive visual analytics system to facilitate efficient analysis of emotion coherence across facial, text, and audio modalities in presentation videos. Our visualization system features a channel coherence view and a sentence clustering view that together enable users to obtain a quick overview of emotion coherence and its temporal evolution. In addition, a detail view and word view enable detailed exploration and comparison from the sentence level and word level, respectively. We thoroughly evaluate the proposed system and visualization techniques through two usage scenarios based on TED Talk videos and interviews with two domain experts. The results demonstrate the effectiveness of our system in gaining insights into emotion coherence in presentations.
TU‐C‐17A‐03: An Integrated Contour Evaluation Software Tool Using Supervised Pattern Recognition for Radiotheray (2014)

Purpose: Radiotherapy (RT) contours delineated either manually or semiautomatically require verification before clinical usage. Manual evaluation is very time consuming. A new integrated software tool using supervised pattern contour recognition was thus developed to facilitate this process. Methods: The contouring tool was developed using an object‐oriented programming language C# and application programming interfaces, e.g. visualization toolkit (VTK). The C# language served as the tool design basis. The Accord.Net scientific computing libraries were utilized for the required statistical data processing and pattern recognition, while the VTK was used to build and render 3‐D mesh models from critical RT structures in real‐time and 360° visualization. Principal component analysis (PCA) was used for system self‐updating geometry variations of normal structures based on physician‐approved RT contours as a training dataset. The inhouse design of supervised PCA‐based contour recognition method was used for automatically evaluating contour normality/abnormality. The function for reporting the contour evaluation results was implemented by using C# and Windows Form Designer. Results: The software input was RT simulation images and RT structures from commercial clinical treatment planning systems. Several abilities were demonstrated: automatic assessment of RT contours, file loading/saving of various modality medical images and RT contours, and generation/visualization of 3‐D images and anatomical models. Moreover, it supported the 360° rendering of the RT structures in a multi‐slice view, which allows physicians to visually check and edit abnormally contoured structures. Conclusion: This new software integrates the supervised learning framework with image processing and graphical visualization modules for RT contour verification. This tool has great potential for facilitating treatment planning with the assistance of an automatic contour evaluation module in avoiding unnecessary manual verification for physicians/dosimetrists. In addition, its nature as a compact and stand‐alone tool allows for future extensibility to include additional functions for physicians’ clinical needs.
Accelerometer with integral bidirectional shock protection and controllable viscous damping (1990)

First Page
Prospects for Thermal Atomic Layer Etching Using Sequential, Self-Limiting Fluorination and Ligand-Exchange Reactions (2016)

Thermal atomic layer etching (ALE) of Al2O3 and HfO2 using sequential, self-limiting fluorination and ligand-exchange reactions was recently demonstrated using HF and tin acetylacetonate (Sn(acac)2) as the reactants. This new thermal pathway for ALE represents the reverse of atomic layer deposition (ALD) and should lead to isotropic etching. Atomic layer deposition and ALE can together define the atomic layer growth and removal steps required for advanced semiconductor fabrication. The thermal ALE of many materials should be possible using fluorination and ligand-exchange reactions. The chemical details of ligand-exchange can lead to selective ALE between various materials. Thermal ALE could produce conformal etching in high-aspect-ratio structures. Thermal ALE could also yield ultrasmooth thin films based on deposit/etch-back methods. Enhancement of ALE rates and possible anisotropic ALE could be achieved using radicals or ions together with thermal ALE.
Alternative Effector-Function Profiling Identifies Broad HIV-Specific T-Cell Responses in Highly HIV-Exposed Individuals Who Remain Uninfected (2014)

The characterization of host immune responses to human immunodeficiency virus (HIV) in HIV controllers and individuals with high exposure but seronegativity to HIV (HESN) is needed to guide the development of effective preventive and therapeutic vaccine candidates. However, several technical hurdles severely limit the definition of an effective virus-specific T-cell response. By using a toggle-peptide approach, which takes HIV sequence diversity into account, and a novel, boosted cytokine staining/flow cytometry strategy, we here describe new patterns of T-cell responses to HIV that would be missed by standard assays. Importantly, this approach also allows detection of broad and strong virus-specific T-cell responses in HESN individuals that are characterized by a T-helper type 1 cytokine-like effector profile and produce cytokines that have been associated with potential control of HIV infection, including interleukin 10, interleukin 13, and interleukin 22. These results establish a novel approach to improve the current understanding of HIV-specific T-cell immunity and identify cellular immune responses and individual cytokines as potential markers of relative HIV resistance. As such, the findings also help develop similar strategies for more-comprehensive assessments of host immune responses to other human infections and immune-mediated disorders.
Fourier domain optical coherence tomography to characterize optical fiber cross sections (2004)

Fourier domain optical coherence tomography is used to reconstruct the cross section of coated optical fibers. A single measurement yields information on the coated and uncoated fiber diameter, and the fiber-coating concentricity.
<title>Microminiature high-resolution linear displacement sensor for peak strain detection in smart structures</title> (1998)

Critical civil and military structures require 'smart' sensors in order to report their strain histories; this can help to insure safe operation after exposure to potentially damaging loads. A passive resetable peak strain detector was developed by modifying the mechanics of a differential variable reluctance transducer. The peak strain detector was attached to an aluminum test beam along with a bonded resistance strain gauge and a standard DVRT. Strain measurements were recorded during cyclic beam deflections. DVRT output was compared to the bonded resistance strain gauge output, yielding correlation coefficients ranging from 0.9989 to 0.9998 for al teste, including re-attachment of the DVRT to the specimen. Peak bending strains were obtained by the modified peak detect DVRT to the specimen. Peak bending strains were obtained by the modified peak detect DVRT and this was compared to the peak bending strains as measured by the bonded strain gauge. The peak detect DVRT demonstrated an accuracy of approximately +/- 5 percent over a peak range of 2000 to 2800 microstrain.
Shadowing effect modeling and compensation for EUV lithography (2011)

Extreme ultraviolet (EUV) lithography is one of the leading technologies for 16nm and smaller node device patterning. One patterning issue intrinsic to EUV lithography is the shadowing effect due to oblique illumination at the mask and mask absorber thickness. This effect can cause CD errors up to a few nanometers, consequently needs to be accounted for in OPC modeling and compensated accordingly in mask synthesis. Because of the dependence on the reticle field coordinates, shadowing effect is very different from the traditional optical and resist effects. It poses challenges to modeling, compensation, and verification that were not encountered in tradition optical lithography mask synthesis. In this paper, we present a systematic approach for shadowing effect modeling and model-based shadowing compensation. Edge based shadowing effect calculation with reticle and scan information is presented. Model calibration and mask synthesis flows are described. Numerical experiments are performed to demonstrate the effectiveness of the approach.
Matrix approach for fast implementations of logarithmic MAP decoding of turbo codes (2002)

This paper describes two new matrix transform algorithms for the max-log-MAP decoding of turbo codes. In the proposed algorithms, the successive decoding procedures carried out in the conventional max-log-MAP algorithm are performed in parallel, and well formulated into a set of simple and regular matrix operations, which can therefore considerably speed up the decoding operations and reduce the computational complexity. The matrix max-log-MAP algorithms also maintain the advantage of the general logarithmic MAP like algorithms in avoiding complex numerical representation problems. They particularly facilitate the implementations of the logarithmic MAP like algorithms in special-purpose parallel processing VLSI hardware architectures. The matrix algorithms also allow simple implementations by using shift registers. The proposed implementation architectures for the matrix max-log-MAP decoding can effectively reduce the memory capacity and simplify the data accesses and transfers required by the conventional max-log-MAP as well as MAP algorithms.
Superhydrophobic materials and coatings: a review (2015)

Over the past few years, the scientific community, as well as the world's coatings industry has seen the introduction of oxide/polymer-based superhydrophobic surfaces and coatings with exceptional water repellency. Online videos have caught the public's imagination by showing people walking through mud puddles without getting their tennis shoes wet or muddy, and water literally flying off coated surfaces. This article attempts to explain the basics of this behavior and to discuss and explain the latest superhydrophobic technological breakthroughs. Since superhydrophobic surfaces and coatings can fundamentally change how water interacts with surfaces, and the fact that earth is a water world, it can legitimately be said that this technology has the potential to literally change the world.
Optimal placement of wavelength converters in trees and trees of rings (2003)

In wavelength-routed optical networks, wavelength converters can potentially reduce the requirement on the number of wavelengths. The problem of placing a minimum number of wavelength converters in a WDM network so that any routing can be satisfied using no more wavelengths than if there were wavelength converters at every node was raised in Wilfong et al. (1998) and shown to be NP-complete in general WDM networks. Recently, it was proved in Kleinberg et al. (1999) that this problem is as hard as the well-known minimum vertex cover problem. In this paper, we further their study in two topologies that are of more practical concrete relevance to the telecommunications industry: trees and tree of rings. We show that the optimal wavelength converter placement problem in these two practical topologies are tractable. Efficient polynomial-time algorithms are presented.
A linear-time method for contender sifting in breadth-first decoding of error control codes (2002)

We introduce a very efficient (linear-time) method for finding the best metrics from among a number of contenders during breadth-first decoding of block or convolutional codes. This method can provide a sorted set of survivor metrics during M algorithm decoding of binary linear block codes using only /spl Lambda/1 comparisons in the worst case. This is a significant improvement over comparison-based sorting, which requires O(M log/sub 2/ M) comparisons. A similar improvement is attained over Hadian and Sohel's comparison-based selection method (where the best metrics are found without regard to order). The method is also readily applicable to the decoding of convolutional codes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optical scanning holography (1996)

This paper provides a tutorial on the principles of holography, followed by a review of a newly developed 3-D imaging technique in which 3-D optical information of an object cam be extracted by a 2-D optical scan of the object. The technique is called optical scanning holography (OSH). In the context of optical scanning holography, we discuss some of its potential applications such as holographic information transmission and television (TV) system, 3-D image coding and decoding, 3-D microscopy, and 3-D optical remote sensing. In most cases, feasibility has been proven but awaits broader application.
BAD Phosphorylation Determines Ovarian Cancer Chemosensitivity and Patient Survival (2011)

The BAD apoptosis pathway influences OVCA chemosensitivity and overall survival, likely via modulation of BAD phosphorylation. The pathway has clinical relevance as a biomarker of therapeutic response, patient survival, and as a promising therapeutic target.
Single Mode Hollow Core Photonic Bandgap Fibers (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. J. Mangan, J. W. Nicholson, R. S. Windeler, T. Kremp, G. Puc, M. Corrado, Y. Dulashko, and D. J. DiGiovanni, "Single Mode Hollow Core Photonic Bandgap Fibers," in Advanced Photonics 2016 (IPR, NOMA, Sensors, Networks, SPPCom, SOF), OSA Technical Digest (online) (Optica Publishing Group, 2016), paper SoM3F.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Get Video Citation alert Save article
A Radiotracer Strategy to Quantify PARP-1 Expression <i>In Vivo</i> Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy (2016)

Despite the availability of PARP inhibitors for cancer therapy, a biomarker to clearly stratify patients for selection of this treatment remains lacking. Here we describe a radiotracer-based method that addresses this issue, using the novel compound [(125)I] KX1: as a PARP-1-selective radiotracer that can accurately measure PARP-1 expression in vitro and in vivo The pharmacologic properties of the PARP radiotracer [(125)I] KX1: was characterized in multiple cell lines where single-agent sensitivity was correlated with [(125)I] KX1: binding to PARP-1. In vivo evaluation of [(125)I] KX1: verified in vitro results, validating PARP radiotracers to define PARP-1 enzyme expression as an in vivo biomarker. Notably, PARP-1 expression as quantified by [(125)I] KX1: correlated positively with the cytotoxic sensitivity of cell lines evaluated with PARP inhibitors. Overall, our results defined a novel technology with the potential to serve as a companion diagnostic to identify patients most likely to respond therapeutically to a PARP inhibitor. Cancer Res; 76(15); 4516-24. ©2016 AACR.
High resolution imaging of a dense plasma with a table-top soft X-ray laser (2002)

We report the results of the first plasma diagnostics experiment conducted utilizing a Y/sup +/ Ne-like table-top soft X-ray laser. The evolution of the plasma of a micro-capillary discharge was studied using a very compact 46.9 nm discharge pumped table-top soft X-ray laser as backlighter.
Experimental investigation of an enhanced thermosyphon heat loop for cooling of a high performance electronics module (2003)

This paper discusses the investigation of module cooling utilizing an enhanced thermosyphon heat loop as an alternative to direct air cooling or liquid-to-air cooling with forced convection of the liquid. Using water as the working fluid in the thermosyphon, experiments were conducted to investigate the effects of fill volume, heat load, and condenser air flow rate on overall thermosyphon performance in terms of thermal resistance. Enhancement of evaporator performance using fins was also investigated and the results are reported in the paper.
Surgical Outcome of Ileal Pouch—Anal Anastomosis When Used Intentionally for Well-Defined Crohnʼs Disease (2012)

Although the intentional use of IPAA in CD has a higher incidence of postoperative disease vs. UC patients, there was no significant difference in pouch failure. Demographics, clinical features, and serologic factors do not predict outcome of CD patients undergoing IPAA. IBD serology may identify the phenotype manifestation of postoperative recurrent CD.