gebhart/patrepeval huggingface dataset:
Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis (2020)

Osteoarthritis (OA) affects nearly 10% of the population of the United States and other industrialized countries and, at present, short of surgical joint replacement, there is no therapy available that can reverse the progression of the disease. Adenosine, acting at its A2A receptor (A2AR), is a critical autocrine factor for maintenance of cartilage homeostasis and here we report that injection of liposomal suspensions of either adenosine or a selective A2AR agonist, CGS21680, significantly reduced OA cartilage damage in a murine model of obesity-induced OA. The same treatment also improved swelling and preserved cartilage in the affected knees in a rat model of established post-traumatic OA (PTOA). Differential expression analysis of mRNA from chondrocytes harvested from knees of rats with PTOA treated with liposomal A2AR agonist revealed downregulation of genes associated with matrix degradation and upregulation of genes associated with cell proliferation as compared to liposomes alone. Studies in vitro and in affected joints demonstrated that A2AR ligation increased the nuclear P-SMAD2/3/P-SMAD1/5/8 ratio, a change associated with repression of terminal chondrocyte differentiation. These results strongly suggest that targeting the A2AR is an effective approach to treat OA.
<title>Ultraviolet 2D fluorescence mapping system for the imaging of head and neck tumors</title> (2000)

Fluorescence images of ex vivo head and neck tissues were acquired at multiple combinations of emission and excitation wavelengths. The wavelength combinations were selected to map different tissue molecules and structures whose fluorescence signatures have bene used to detect cancer. Fluorescence maps were generated by ratioing fluorescence image intensities. These ratio maps enhanced the ability to recognize regions of tumor and other features in tissues. Histopathological analysis was performed on the tissue samples. Location and shape of features observed in the fluorescence images were correlated with structures observed in histopathology.
<i>Caulobacter crescentus</i> Synthesizes an S-Layer-Editing Metalloprotease Possessing a Domain Sharing Sequence Similarity with Its Paracrystalline S-Layer Protein (2002)

Strains of Caulobacter crescentus elaborate an S-layer, a two-dimensional protein latticework which covers the cell surface. The S-layer protein (RsaA) is secreted by a type I mechanism (relying on a C-terminal signal) and is unusual among type I secreted proteins because high levels of protein are produced continuously. In efforts to adapt the S-layer for display of foreign peptides and proteins, we noted a proteolytic activity that affected S-layer monomers with foreign inserts. The cleavage was precise, resulting in fragments with an unambiguous N-terminal sequence. We developed an assay to screen for loss of this activity (i.e., presentation of foreign peptides without degradation), using transposon and traditional mutagenesis. A metalloprotease gene designated sap (S-layer-associated protease) was identified which could complement the protease-negative mutants. The N-terminal half of Sap possessed significant similarity to other type I secreted proteases (e.g., alkaline protease of Pseudomonas aeruginosa), including the characteristic RTX repeat sequences, but the C-terminal half which normally includes the type I secretion signal exhibited no such similarity. Instead, there was a region of significant similarity to the N-terminal region of RsaA. We hypothesize that Sap evolved by combining the catalytic portion of a type I secreted protease with an S-layer-like protein, perhaps to associate with nascent S-layer monomers to "scan" for modifications.
A novel G protein-coupled receptor kinase gene cloned from 4p16.3 (1992)

Within the Huntington's disease (HD) candidate region of 4p16.3, the D4S127 locus displays strong linkage disequilibrium with the defect and anchors a conserved haplotype found on many HD chromosomes. To isolate genes from this region we have applied the exon amplification technique to overlapping cosmids spanning D4S127. Here, we report the discovery of a new gene encoding a novel member of a family of protein kinases that specifically phosphorylate the activated forms of G protein-coupled receptors. Such kinases are thought to participate in desensitization of specific receptors, thereby blocking further signal transduction. This gene must now be carefully scrutinized to determine whether it might be involved in HD.
Correction to An <i>N</i>-Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy (2021)

ADVERTISEMENT RETURN TO ISSUEPREVCorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to An N-Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted RadioimmunotherapySarah M. ChealSarah M. ChealMore by Sarah M. Cheal, Mitesh PatelMitesh PatelMore by Mitesh Patel, Guangbin YangGuangbin YangMore by Guangbin Yang, Darren R. VeachDarren R. VeachMore by Darren R. Veach, Hong XuHong XuMore by Hong Xu, Hong-fen GuoHong-fen GuoMore by Hong-fen Guo, Pat B. ZanzonicoPat B. ZanzonicoMore by Pat B. Zanzonico, Donald B. AxworthyDonald B. AxworthyMore by Donald B. Axworthy, Nai-Kong V. CheungNai-Kong V. CheungMore by Nai-Kong V. Cheung, Ouathek OuerfelliOuathek OuerfelliMore by Ouathek Ouerfelli, and Steven M. Larson*Steven M. LarsonMore by Steven M. Larsonhttp://orcid.org/0000-0002-6111-7507Cite this: Bioconjugate Chem. 2021, 32, 2, 394Publication Date (Web):January 24, 2021Publication History Published online25 January 2021Published inissue 17 February 2021https://pubs.acs.org/doi/10.1021/acs.bioconjchem.0c00686https://doi.org/10.1021/acs.bioconjchem.0c00686correctionACS PublicationsCopyright © 2021 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views738Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (474 KB) Get e-AlertscloseSUBJECTS:Absorption,Anatomy,Cancer therapy,Radiation,Tumors Get e-Alerts
Determination of Prostacyclin in Plasma through a Bioluminescent Immunoassay for 6-Keto-prostaglandin F<sub>1</sub><sub>α</sub>:  Implication of Dosage in Patients with Primary Pulmonary Hypertension (2002)

This work describes a solid-phase immunoassay for 6-keto-prostaglandin F1alpha, the stable hydrolysis product of prostacyclin (prostaglandin I2). Prostacyclin, a potent vasodilator with antiplatelet and antiproliferative properties is an effective treatment for primary pulmonary hypertension and pulmonary arterial hypertension associated with scleroderma and scleroderma-like syndrome. Levels of 6-keto-prostaglandin F1alpha can be directly correlated with levels of prostacyclin. Therefore, 6-keto-prostaglandin F1alpha, has become the indicator of choice to measure prostacyclin levels. The single-step immunoassay for 6-keto-prostaglandin F1alpha reported here was developed using the bioluminescent protein aequorin as a label. Analyte-label conjugates were constructed by linking the carboxyl group of 6-keto-prostaglandin F1alpha and lysine residues of aequorin by chemical conjugation methods. The binding properties of 6-keto-prostaglandin F1alpha toward its antibody and the bioluminescent properties of aequorin were retained in the conjugate, which was then used to generate a dose-response curve for the analyte in a convenient microtiter plate format. The concentration of 6-keto-prostaglandin F1alpha after extraction from plasma showed good correlation with the concentration of 6-ketoprostaglandin F1alpha obtained without prior extraction of the same plasma sample. This measurement demonstrated that the assay allows the measurement of 6-keto-prostaglandin F1alpha directly in plasma without any pretreatment of the samples, which results in a much simpler method with a faster assay time.
Extraction of multiple-bounce echoes in SAR image formation (2003)

This analysis develops an innovative SAR image formation algorithm that separates direct-scatter echoes in an image from echoes that are the result of multiple bounces, and then maps each set of reflections to a metrically correct image space. Current processing schemes place the multiple-bounce (MB) echoes at incorrect (i.e., ghost) locations due to fundamental assumptions implicit in conventional processing. Two desired results are achieved by use of this new Image Reconstruction Algorithm for Multi-bounce Scattering (IRAMS). First, ghost returns are eliminated from the primary image space, thereby improving the relationship between the image pattern and the physical distribution of the scatterers. Second, a set of auxiliary "delay" image planes containing only MB echoes is created which possesses characteristic information about the scene being imaged. These auxiliary image planes offer the potential of improving target detection and identification capabilities.
Strain‐specific vulnerability to alcohol exposure <i>in utero via</i> hippocampal parent‐of‐origin expression of deiodinase‐III (2011)

Prenatal exposure to alcohol is thought to be the most prevalent nongenetic cause of a wide range of neurodevelopmental deficits. Insufficient thyroid hormone levels are one mechanism that hampers development of the alcohol-exposed brain, and we hypothesized that altered dosage of the imprinted thyroid hormone-inactivating gene deiodinase-III (Dio3) is responsible. To follow parent-of-origin allelic expression of Dio3 in the fetal and adult offspring of alcohol-consuming and control dams, we reciprocally crossed 2 polymorphic rat strains. In the frontal cortex, prenatal alcohol exposure altered imprinting patterns and total expression of Dio3 in the fetus and produced a permanent hypothyroid milieu in the adult. In the hippocampus, alcohol affected the paternal and total expression of Dio3 in the fetus and in the adult male, where thyroid hormone levels were concomitantly increased. Hippocampus-dependent behavioral deficits were identified exclusively in males, suggesting they are dependent on aberrant allelic Dio3 expression. None of these effects were observed in offspring of the reciprocal cross. Thus, genetic background and sex modify vulnerability to prenatal alcohol via brain region-specific expression of Dio3. This finding implies that phenotypic heterogeneity in human fetal alcohol spectrum disorder can be linked to genetic vulnerability in affected brain regions.
Modeling erbium-doped fiber amplifiers (1991)

Erbium-doped fiber amplifiers are modeled using the propagation and rate equations of a homogeneous two-level laser medium. Numerical methods are used to analyze the effects of optical modes and erbium confinement on amplifier performance, and to calculate both the gain and amplified spontaneous emission (ASE) spectra. Fibers with confined erbium doping are completely characterized from easily measured parameters: the ratio of the linear ion density to fluorescence lifetime, and the absorption of gain spectra. Analytical techniques then allow accurate evaluation of gain, saturation, and noise in low-gain amplifiers (G<or approximately=20 dB).<<ETX>>
Demonstration of a space-to-time conversion based on a time-space conversion technique among time signals and 2-D space ones (2002)

We demonstrate a direct space-to-time conversion based on a new technique for the ultra-fast optical time-to-2D-space-to-time-to-2D-space conversion technique.
Phase II Study of Bortezomib in Waldenstrom’s Macroglobulinemia: Results of WMCTG Trial 03-248. (2005)

Abstract In this multi-center phase II study, 27 patients with the consensus panel definition of Waldenstrom’s macroglobulinemia received bortezomib as a single agent. All but one patient had relapsed/or refractory disease, and the median number of prior therapies was 2 (range 0–3). Intended therapy consisted of 8 cycles of bortezomib at 1.3 mg/m2 on days 1,4,8,11. Twenty-six patients have completed therapy and are eligible for evaluation. The median age for this group was 62 (44–79 years) and baseline laboratories were as follows: serum IgM: 4,565 (1,067–9,330 mg/dl); bone marrow (BM) involvement 30% (1–95%); and hematocrit 34.9% (25.6–45.3%). Following a median of 6 cycles of therapy, serum IgM levels decreased in 25/26 patients to a median of 2,685 (125–5,650 mg/dl), while hematocrit rose in 20/26 patients to a median of 37.2% (30.9–46.3%). The overall response rate was 84.6%, with 11 and 11 patients achieving a minor (&lt;25% decrease in IgM) and partial (&lt;50% decrease in IgM) response, respectively, using consensus panel criteria. Post therapy bone marrow biopsies were not required for response determination, but were available for 8 patients who demonstrated a median decrease in bone marrow involvement from 37.5%(range 20–55%) to 17.5% (range 5–48%). However, in 3 of 8 patients discordance between serum IgM levels, bone marrow involvement and/or adenopathy was demonstrated including in one patient who demonstrated a decrease in serum IgM levels from 2,291 to 618 mg/dL whilst bone marrow involvement rose from 25% to 48%. With a median follow-up of 8 months, 10 patients have demonstrated progressive disease. In general, therapy was well tolerated with grade III/IV toxicities as follows: neutropenia (15%); sensory neuropathies (12%); thrombocytopenia (8%); pleural effusion (4%); neuropathic pain (4%); diarrhea (4%); infection (8%); anorexia (8%); and fatigue (4%). The results of these studies demonstrate that bortezomib is an active agent in the salvage setting for patients with WM, and may independent of direct tumor cell killing inhibit secretion of IgM in some patients. Moreover, BM biopsies and CT scans (if baseline adenopathy or splenomegaly were present) should be considered to assess response in WM patients receiving bortezomib. In view of these results, a phase II study of bortezomib in combination with dexamethasone and rituximab has been initiated in patients with WM.
Soft-Output Decoding of 17 Parity Preserve/Prohibit Repeated Minimum Transition Runlength (PP) Code (2004)

We propose a novel trellis decoding technique for soft-output decoding of 17 parity preserve/prohibit repeated minimum transition runlength (PP) code. The trellis of the 17 PP code has 21 states and 79 branches. We applied the Bahl-Cocke-Jelinek-Raviv (BCJR) algorithm to the trellis to obtain a soft-input soft-output (SISO) decoder. Using this SISO decoder, we have developed a turbo-coded 17 PP system for optical recording. It is experimentally confirmed that the turbo-coded 17 PP system effectively improves the bit error rate (BER) of high-density optical storage.
Antiestrogenic Glyceollins Suppress Human Breast and Ovarian Carcinoma Tumorigenesis (2006)

These findings identify glyceollins as antiestrogenic agents that may be useful in the prevention or treatment of breast and ovarian carcinoma.
Optimizing system monitoring configurations for non-actionable alerts (2012)

Today's competitive business climate and the complexity of IT environments dictate efficient and cost effective service delivery and support of IT services. This is largely achieved through automating of routine maintenance procedures including problem detection, determination and resolution. System monitoring provides effective and reliable means for problem detection. Coupled with automated ticket creation, it ensures that a degradation of the vital signs, defined by acceptable thresholds or monitoring conditions, is flagged as a problem candidate and sent to supporting personnel as an incident ticket. This paper describes a novel methodology and a system for minimizing non-actionable tickets while preserving all tickets which require corrective action. Our proposed method defines monitoring conditions and the optimal corresponding delay times based on an off-line analysis of historical alerts and the matching incident tickets. Potential monitoring conditions are built on a set of predictive rules which are automatically generated by a rule-based learning algorithm with coverage, confidence and rule complexity criteria. These conditions and delay times are propagated as configurations into run-time monitoring systems.
A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3. (2002)

Frequent allelic loss and homozygous deletions within chromosome 3p in human lung cancers have suggested that the 3p21.3 (370-kb) region contains a critical tumor suppressor gene(s) (TSG). With the exact identity/characteristics of such a gene(s) still unconfirmed, a lack of inactivating structural mutations in the expressed genes contained within this region may indicate that the 3p TSG(s) do not fit into the classical "two-mutation" model. This report characterizes a candidate 3p TSG, H37, located within the 370-kb region. Reduced expression of the H37 transcript was found in 9 of 11 (82%) of primary non-small cell lung cancers (NSCLCs) when compared with adjacent normal tissues. Generation of an H37 antibody followed by immunohistochemical analysis of primary NSCLC specimens demonstrated that 46 of 62 (73%) of these cancers contain reduced levels of H37 protein when compared with adjacent normal bronchial cells. Moreover, introduction of the H37 cDNA into human breast cancer cells deleted of 3p21-22 reduced both anchorage-dependent and -independent cell growth in vitro. Subsequent transfection of H37 cDNA into one of the human lung cancer cell lines homozygously deleted in this region resulted in a very low yield of H37-expressing clones. H37 also suppressed anchorage-dependent and -independent growth of A9 mouse fibrosarcoma cells and inhibited tumor formation in nude mice. These data indicate a potential role for H37 as one of the 3p TSGs in human lung cancer.
Digital watermarking in a perceptually normalized domain (2003)

One of the fundamental issues in digital watermarking is to find the best trade-off between imperceptibility and robustness to signal processing. Properties of human visual systems (HVS) have been exploited to achieve this goal. Previously, researchers have made use of frequency sensitivity, luminance sensitivity and visual masking effect of the HVS to adaptively control the amount of watermark energy to be embedded into different transform coefficients of the image. We present an alternative approach that first nonlinearly transforms the original signal to a perceptually uniform domain, then embeds a constant amount of watermark to each sample in this domain. We show that the derivation of an optimal watermark detector is straightforward in this approach, as opposed to some previous approaches. The advantage of exploiting the neighborhood-masking effect is also briefly discussed.
A portable gamma dose-rate meter for survival use. Technical note (1976)

A miniature gamma dose-rate meter is described which uses three differently coloured flashing light emitting diodes to cover the dose-rate range 0.1 to 100 R/h. This low cost instrument has considerable potential as a survival instrument for both military and civilian application. (GRA)
Circuit for suppressing amplitude peaks caused by stop consonants in an electroacoustic transmission system (1989)

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Advanced Thermochromic Ink System for Medical Blood Simulation (2021)

Simulators for extracorporeal membrane oxygenation (ECMO) have problems of bulky devices and low-fidelity methodologies. Hence, ongoing efforts for optimizing modern solutions focus on minimizing expenses and blending training with the intensive care unit. This is particularly evident following the coronavirus pandemic, where economic resources have been extensively cut. In this paper, as a part of an ECMO simulator for training management, an advance thermochromic ink system for medical blood simulation is presented. The system was developed and enhanced as a prototype with successful and reversible transitions between dark and bright red blood color to simulate blood oxygenation and deoxygenation in ECMO training sessions.
Detection of the Human Rhinovirus Minor Group Receptor on Renaturing Western Blots (1988)

The human rhinovirus minor group receptor was extracted from HeLa cell membranes and partially purified. Receptor activity was detected on Western blots by binding of 35S-labelled human rhinovirus serotype 2 to the immobilized protein at a position corresponding to an Mr of 120 x 10(3).
Efficient state merging in symbolic execution (2012)

Symbolic execution has proven to be a practical technique for building automated test case generation and bug finding tools. Nevertheless, due to state explosion, these tools still struggle to achieve scalability. Given a program, one way to reduce the number of states that the tools need to explore is to merge states obtained on different paths. Alas, doing so increases the size of symbolic path conditions (thereby stressing the underlying constraint solver) and interferes with optimizations of the exploration process (also referred to as search strategies). The net effect is that state merging may actually lower performance rather than increase it.
Enhanced polyhydroxybutyrate (PHB) production<i>via</i>the coexpressed<i>phaCAB</i>and<i>vgb</i>genes controlled by arabinose P<sub>BAD</sub>promoter in<i>Escherichia coli</i> (2009)

We were successful in providing a new coexpressed system for PHB synthesis in E. coli. This coexpressed system could be regulated by arabinose inducer, and is more stable and cheaper than other induced systems (e.g. IPTG). Furthermore, it could be applied in many biotechnology or fermentation processes.
Uplink Adaptive Resource Allocation Mitigating Inter-Cell Interference Fluctuation for Future Cellular Systems (2007)

This paper aims to address the problem of inter-cell interference fluctuation, which is inherent on the uplink direction of future cellular systems employing OFDMA or single carrier as multiple access technology. We present here a novel uplink adaptive resource allocation algorithm based on inter-cell interference measurement to achieve both multi-user diversity gain and the cancellation of inter-cell interference fluctuation. The phenomenon of inter-cell interference fluctuation in future cellular systems is explained and its negative effect on traditional resource allocation methods is analyzed. The proposed algorithm includes two independent sub-algorithms: 1) user grouping based resource allocation scheme, in which radio resource is limited to be reallocated within a group of users generating close inter-cell interference; 2) power compensation based resource allocation scheme, in which inter-cell interference fluctuation is compensated by adjusting transmitting power of UE. And performance evaluation results show that our algorithms smooth the inter-cell interference successfully and can improve system spectrum efficiency by 10-15% compared with existing traditional adaptive resource allocation schemes.