gebhart/patrepeval huggingface dataset:
Reprotoxicity of gold, silver, and gold–silver alloy nanoparticles on mammalian gametes (2013)

Metal and alloy nanoparticles are increasingly developed for biomedical applications, while a firm understanding of their biocompatibility is still missing. Various properties have been reported to influence the toxic potential of nanoparticles. This study aimed to assess the impact of nanoparticle size, surface ligands and chemical composition of gold, silver or gold-silver alloy nanoparticles on mammalian gametes. An in vitro assay for porcine gametes was developed, since these are delicate primary cells, for which well-established culture systems exist and functional parameters are defined. During coincubation with oocytes for 46 h neither any of the tested gold nanoparticles nor the gold-silver alloy particles with a silver molar fraction of up to 50% showed any impact on oocyte maturation. Alloy nanoparticles with 80% silver molar fraction and pure silver nanoparticles inhibited cumulus-oocyte maturation. Confocal microscopy revealed a selective uptake of gold nanoparticles by oocytes, while silver and alloy particles mainly accumulated in the cumulus cell layer surrounding the oocyte. Interestingly sperm vitality parameters (motility, membrane integrity and morphology) were not affected by any of the tested nanoparticles. Only sporadic association of nanoparticles with the sperm plasma membrane was found by transmission electron microscopy. In conclusion, mammalian oocytes were sensitive to silver containing nanoparticles. Likely, the delicate process of completing meiosis in maternal gametes features high vulnerability towards nanomaterial derived toxicity. The results imply that released Ag(+)-ions are responsible for the observed toxicity, but the compounding into an alloy seemed to alleviate the toxic effects to a certain extent.
p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I. (1985)

Human T-cell leukemia virus type I (HTLV-I) is an etiological agent of adult T-cell leukemia and has a unique sequence, pX, that contains four possible open reading frames, I-IV. p40x was previously identified as the gene product of frame IV (x-lor) and was suggested to mediate transcriptional trans-activation of the viral long terminal repeats. We have identified two pX gene products, p27x-III and p21x-III, encoded by frame III, which mostly overlapped frame IV. These proteins were detected with rabbit antiserum against the synthetic peptide predicted from the 3' end of frame III. p27x-III is phosphorylated in cultured cells, and the phosphoprotein (pp27x-III) is localized in nuclei; some pp27x-III was tightly bound to nuclear components. p27x-III was detected in a number of cell lines that express other viral antigens, including a cell line previously reported to express only p40x as a viral protein. The function(s) of p27x-III and p21x-III is not known, but the tight binding of pp27x-III to nuclear components suggests that it is associated with regulation of viral gene expression.
Ultrahigh-sensitivity low coherence otdr using Er <sup>1+</sup> -doped high-power superfluorescent fibre source (1992)

The first-known demonstration of an Er3+-doped superfluorescent fibre source coupled to a high-resolution OTDR based on low coherence interference (low coherence OTDR) is reported. Linearly-polarised light with 14 mW output from the source achieves a – 146dB minimum detectable reflectivity at 3 Hz bandwidth. The spatial resolution determined by spectral FWHM is 28 μm for silica-based waveguides.
Fiber-Matrix Adhesion and Its Effect on Composite Mechanical Properties. III. Longitudinal (0°) Compressive Properties of Graphite/Epoxy Composites (1992)

An experimental investigation was performed to quantify the relationship between fiber-matrix adhesion as determined by single fiber interfacial shear strength tests with the compressive properties and failure modes of unidirectional graphite/epoxy com posites. The compression tests were conducted on three identical sets of composites differ ing only in their fiber-matrix interfacial shear strength. The interfacial shear strength was varied by using the same graphite fibers with different surface treatments, namely un treated, surface treated, and surface treated and coated with a thin layer of epoxy. The sur face treatment changed the interfacial shear strength by more than a factor of two, while the properties of the fibers remained unchanged. The experimental results show that the fiber surface treatment affects the compressive modulus only marginally. However, the compressive strength and maximum compressive strain were highly sensitive to the fiber surface treatment. Both the strength and maximum strain increased with the interfacial shear strength. The fracture surface analysis revealed that when the fiber-matrix inter facial shear strength was low the compressive failure occurred due to delamination and global delamination buckling. At intermediate values of the interfacial shear strength, the compressive failure occurred due to shear failure driven by inphase microbuckling of fibers. The composites having the highest values of the interfacial shear strength yielded "stepped" fracture surfaces showing compressive failure of fibers in several planes perpen dicular to the fiber axis.
Enterprise Architecture Content Model Applied to Complexity Management While Delivering IT Services (2014)

Complex information technology (IT) installations within an enterprise raise contextual challenges when delivering IT service management (ITSM) that maintain and enhance software for the business. Enterprise Architecture (EA) tools are now available to represent context as business processes, services and enabling IT components. However, few methods exist to leverage these representations for the management of complexity that exits in the EA. In this paper, we contribute towards this emerging area of research by posing fundamental questions: 1) "what makes an IT service complex to deliver and by what measures?" and 2) "what is the complexity management?" To answer these questions, we begin by examining related work in measures of software complexity. Next, we use a graph-based framework to identify complexity patterns that exist in the real world. Using the framework and case study method we show the relationships between the difficulty of service delivery and complexity patterns in the EA context. Generalizing from this, we propose principles for the complexity management.
Information-based Modeling of Diachronic Linguistic Change: from Typicality to Productivity (2016)

We present a new approach for modeling diachronic linguistic change in grammatical usage. We illustrate the approach on English scientific writing in Late Modern English, focusing on grammatical patterns that are potentially indicative of shifts in register, genre and/or style. Commonly, diachronic change is characterized by the relative frequency of typical linguistic features over time. However, to fully capture changing linguistic usage, feature productivity needs to be taken into account as well. We introduce a data-driven approach for systematically detecting typical features and assessing their productivity over time, using information-theoretic measures of entropy and surprisal.
Twists, Tilings, and Tessellations (2017)

Twists, Tilings, and Tessellation describes the underlying principles and mathematics of the broad and exciting field of abstract and mathematical origami, most notably the field of origami tessellations. It contains folding instructions, underlying principles, mathematical concepts, and many beautiful photos of the latest work in this fast-expanding field.
High-power high-efficiency continuous-wave InGaN laser diodes in the violet, blue, and green wavelength regimes (2010)

We present new advances in green, blue, and violet InGaN-based laser diodes fabricated on nonpolar and semipolar GaN substrates. Using these novel crystal orientations, we report high power, high efficiency, continuous-wave operation from single-lateral-mode electrically pumped laser diodes at wavelengths from 405 nm to 500 nm. Additionally, we present continuous-wave lasing demonstrations out to 523 nm, representing the longest continuous-wave green laser emission reported to date. Wall-plug efficiencies of over 25% in the violet region, 16.2% in the blue region, and 2.2% in the 500 nm range are presented. These InGaN-based devices offer dramatic improvement in size, weight, and cost over conventional gas or solid state lasers and may enable a variety of new applications in defense, biomedical, industrial, and consumer projection displays.
SET tolerant CMOS comparator (2004)

A novel way to mitigate single event transients (SETs) in a comparator by using auto-zeroing techniques is presented. Two comparators, a folded cascode comparator and a novel auto-zeroed comparator, are simulated using a current pulse model for a single event strike. These simulations show that the novel auto-zeroed comparator transients are never longer in duration than a single auto-zero clock period. This compares favorably to a folded cascode comparator sample circuit, whose maximum transient duration is strongly dependent on the differential input voltage and can be four times as long. The use of the presented auto zero comparator can practically eliminate the comparator contribution to single event errors in many mixed signal circuits, such as analog-to-digital converters (ADCs).
Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients (1999)

Objective: To assess risk factors for mortality in cardiac surgical adult patients as part of a study to develop a European System for Cardiac Operative Risk Evaluation (EuroSCORE). Methods: From September to November 1995, information on risk factors and mortality was collected for 19030 consecutive adult patients undergoing cardiac surgery under cardiopulmonary bypass in 128 surgical centres in eight European states. Data were collected for 68 preoperative and 29 operative risk factors proven or believed to inuence hospital mortality. The relationship between risk factors and outcome was assessed by univariate and logistic regression analysis. Results: Mean age ( ^standard deviation) was 62:5 ^10:7 (range 1794 years) and 28% were female. Mean body mass index was 26:3 ^3:9. The incidence of common risk factors was as follows: hypertension 43.6%, diabetes 16.7%, extracardiac arteriopathy 2.9%, chronic renal failure 3.5%, chronic pulmonary disease 3.9%, previous cardiac surgery 7.3% and impaired left ventricular function 31.4%. Isolated coronary surgery accounted for 63.6% of all procedures, and 29.8% of patients had valve operations. Overall hospital mortality was 4.8%. Coronary surgery mortality was 3.4% In the absence of any identiable risk factors, mortality was 0.4% for coronary surgery, 1% for mitral valve surgery, 1.1% for aortic valve surgery and 0% for atrial septal defect repair. The following risk factors were associated with increased mortality: age (P 0:001), female gender (P 0:001), serum creatinine (P 0:001), extracardiac arteriopathy (P 0:001), chronic airway disease (P 0:006), severe neurological dysfunction (P 0:001), previous cardiac surgery (P 0:001), recent myocardial infarction (P 0:001), left ventricular ejection fraction (P 0:001), chronic congestive cardiac failure (P 0:001), pulmonary hypertension (P 0:001), active endocarditis (P 0:001), unstable angina (P 0:001), procedure urgency (P 0:001), critical preoperative condition (P 0:001) ventricular septal rupture (P 0:002), noncoronary surgery (P 0:001), thoracic aortic surgery (P 0:001). Conclusion: A number of risk factors contribute to cardiac surgical mortality in Europe. This information can be used to develop a risk stratication system for the prediction of hospital mortality and the assessment of quality of care.
Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice (2011)

To assess the influence of mannosylated glycans on the immunogenicity of human immunodeficiency virus type 1 (HIV-1) Env proteins, we immunized mice with monomeric gp120 in the presence and absence of the mannose-binding protein, griffithsin (GRFT). For comparison, other groups of mice received the nonglycosylated HIV-1 Gag protein, with and without GRFT. Coimmunization with GRFT increased the anti-gp120 IgG reactivity significantly, but had no effect on the anti-Gag response. We also investigated the IgG response to GRFT and found that gp120, but not Gag, enhanced its immunogenicity. For both proteins, IgG1 antibodies dominated the IgG response, with IgG2b as the next most prevalent subclass. We conclude that gp120-GRFT complexes are more immunogenic than the free proteins, for both components, and that occluding the mannose moieties on monomeric gp120 can improve the humoral immune response to this protein.
Network density control in epoxy–silica hybrids by selective silane functionalization of precursors (2005)

Abstract Following previous work on the compatibilization of organic–inorganic hybrids through coupling reactions with the precursor components, the present study evaluates the relative efficiency of different types of coupling agents on the morphology and properties of epoxy–silica hybrids. In particular, this investigation compares the effects of introducing trialkoxysilane functional groups at the chain end (using amine‐ and mercapto‐silanes) with similar types grafted in the middle of the chain of the constituent resin (using an isocyanate silane). The use of coupling agents with a basic character (amine silane type) brings about the formation of denser networks in both constituent phases of the resulting epoxy–silica hybrid, which is manifest through a large increase in the T g and a more extensive suppression of the molecular relaxations within the glass transition regions. Increasing the number of alkoxysilane functional groups at the chain end, with the use of a bis‐aminosilane, has a relatively minor effect on the morphology and dynamic mechanical spectra of the resulting epoxy–silica hybrids. It was also found that while the incorporation of small amounts of a high molecular weight epoxy resin causes considerable plasticization of the organic phase, much larger amounts of organic (aliphatic) co‐agent within the siloxane phase are required to deteriorate those properties that are related to the inorganic character of the hybrid material. © 2005 Wiley Periodicals, Inc. Adv Polym Techn 24:91–102, 2005; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/adv.20033
Working with the National Cancer Institute (1997)

The National Cancer Institute (NCI) has recently been reorganized, with drug development focused in the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). The Developmental Therapeutics Program (DTP) of DCTDC promotes all aspects of the discovery and preclinical development of new compounds as drugs. Its activities include demonstration of antiproliferative activity in vitro through its 60 human tumor cell line screen and in vivo using tumor cell xenografts in athymic mice. Compounds of interest for further development are studied to develop a suitable formulation, optimal route and schedule, pharmacology, and toxicology. The Cancer Therapy Evaluation Program (CTEP) of DCTDC is responsible for submitting to the Food and Drug Administration Investigational New Drug Applications (INDAs) for those drugs in which the NCI will hold the IND and study in its peer-reviewed funded clinical trial groups, or as part of the activities of Phase I and II cooperative agreement organizations. CTEP also monitors the conduct of these studies as well as Phase III studies focusing on the optimal use of currently available FDA-approved agents.
Treatment of volatile organic compounds contained in soil by pulsed intense relativistic electron beam irradiation (2010)

Abstract A volatile organic compound (VOC) contained in soil was treated by irradiation with a pulsed intense relativistic electron beam (PIREB). A treatment chamber was filled with the molded soil sample containing formaldehyde solution as a VOC, and was irradiated by a PIREB (2 MeV, 0.4 kA, 70 ns). The soil sample was a mixture of red and black clay representing the Kanto loam in Japan. The diffused formaldehyde of 64% is resolved by firing five shots of the PIREB at the initial concentration of 55 ppm. Copyright © 2010 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Response to Intravenous Allogeneic Equine Cord Blood-Derived Mesenchymal Stromal Cells Administered from Chilled or Frozen State in Serum and Protein-Free Media (2016)

Equine mesenchymal stromal cells (MSC) are commonly transported, chilled or frozen, to veterinary clinics. These MSC must remain viable and minimally affected by culture, transport, or injection processes. The safety of two carrier solutions developed for optimal viability and excipient use were evaluated in ponies, with and without allogeneic cord blood-derived (CB) MSC. We hypothesized that neither the carrier solutions nor CB-MSC would elicit measurable changes in clinical, hematological, or biochemical parameters. In nine ponies (study 1), a bolus of HypoThermosol(®) FRS (HTS-FRS), CryoStor(®) CS10 (CS10), or saline was injected IV (n = 3/treatment). Study 2, following a 1-week washout period, 5 × 10(7) pooled allogeneic CB-MSCs were administered IV in HTS-FRS following 24 h simulated chilled transport. Study 3, following another 1-week washout period 5 × 10(7) pooled allogeneic CB-MSCs were administered IV in CS10 immediately after thawing. Nine ponies received CB-MSCs in study 2 and 3, and three ponies received the cell carrier media without cells. CB-MSCs were pooled in equal numbers from five unrelated donors. In all studies, ponies were monitored with physical examination, and blood collection for 7 days following injection. CD4 and CD8 lymphocyte populations were also evaluated in each blood sample. In all three studies, physical exam, complete blood cell count, serum biochemistry, and coagulation panel did not deviate from established normal ranges. Proportions of CD4(+) and CD8(+) lymphocytes increased at 168 h postinjection in CB-MSC treatment groups regardless of the carrier solution. Decreases in CD4(+/)CD8(+) double positive populations were observed at 24 and 72 h in CB-MSC-treated animals. There was no difference in viability between CB-MSCs suspended in HTS-FRS and CS10. HTS-FRS and CS10 used for low volume excipient injection of MSC suspensions were not associated with short-term adverse reactions. HTS-FRS and CS10 both adequately maintain CB-MSC viability following hypothermic or frozen simulated transport, respectively. CB-MSCs do not elicit clinical abnormalities, but allogeneic stimulation of CD4(+) and CD8(+) lymphocyte populations may occur. Future studies should include in vitro or in vivo evaluation of cell-mediated or adaptive immunity to autologous, identical allogeneic, or MSC originating from additional unrelated individuals in order to better characterize this response.
Near-field terahertz probes with room-temperature nanodetectors for subwavelength resolution imaging (2017)

Near-field imaging with terahertz (THz) waves is emerging as a powerful technique for fundamental research in photonics and across physical and life sciences. Spatial resolution beyond the diffraction limit can be achieved by collecting THz waves from an object through a small aperture placed in the near-field. However, light transmission through a sub-wavelength size aperture is fundamentally limited by the wave nature of light. Here, we conceive a novel architecture that exploits inherently strong evanescent THz field arising within the aperture to mitigate the problem of vanishing transmission. The sub-wavelength aperture is originally coupled to asymmetric electrodes, which activate the thermo-electric THz detection mechanism in a transistor channel made of flakes of black-phosphorus or InAs nanowires. The proposed novel THz near-field probes enable room-temperature sub-wavelength resolution coherent imaging with a 3.4 THz quantum cascade laser, paving the way to compact and versatile THz imaging systems and promising to bridge the gap in spatial resolution from the nanoscale to the diffraction limit.
Proposed System for data hiding using Cryptography and Steganography (2010)

Steganography and Cryptography are two popular ways of sending vital information in a secret way. One hides the existence of the message and the other distorts the message itself. There are many cryptography techniques available; among them AES is one of the most powerful techniques. In Steganography we have various techniques in different domains like spatial domain, frequency domain etc. to hide the message. It is very difficult to detect hidden message in frequency domain and for this domain we use various transformations like DCT, FFT and Wavelets etc. In this project we are developing a system where we develop a new technique in which Cryptography and Steganography are used as integrated part along with newly developed enhanced security module. In Cryptography we are using AES algorithm to encrypt a message and a part of the message is hidden in DCT of an image; remaining part of the message is used to generate two secret keys which make this system highly secured.
Major Bacteria of Community-Acquired Respiratory Tract Infections in Turkey (2005)

To determine the bacterial etiology of lower respiratory tract infections (LRTIs) in Turkey, quantitative cultures of sputum were carried out. The major pathogens for LTRIs were found to be Haemophilus influenzae, followed by Streptococcus pneumoniae and Moraxella catarrhalis. Only 6.1% of the H. inlfuenzae and all strains of M. catarrhalis were beta-lactamase producers. An E-test showed that 31.2% of the S. pneumoniae strains had an intermediate resistance to penicillin, and the remaining strains were susceptible; no fully resistant strains were detected.
Expression of two type 2N von Willebrand disease mutations identified in exon 18 of von Willebrand factor gene (2004)

Type 2N von Willebrand disease (VWD) is characterized by a markedly decreased affinity of von Willebrand factor (VWF) for factor VIII (FVIII). The FVIII binding site has been localized within the first 272 amino acid residues of mature VWF, encoded by exons 18-23. Two substitutions in exon 18 of VWF gene, inducing candidate mutations Y795C and C804F were identified in the heterozygous state in two French patients who also displayed the frequent R854Q mutation in exon 20. Expression studies in Cos-7 cells showed that these abnormalities, which implicate cysteine residues, induced secretion, multimerization and FVIII binding defects of corresponding recombinant VWF. Results from transfection experiments with R854Q, performed to reproduce the hybrid VWF present in patient plasma, were in agreement with those obtained for patient's plasma VWF. These findings confirm the importance of the VWF D' domain in FVIII binding. In addition, this work shows that exon 18 should preferentially be sequenced in type 2N VWD patients when the frequent R854Q mutation in exon 20 has been excluded or detected in the heterozygous state.