gebhart/patrepeval huggingface dataset:
Direct photo-etching of poly(methyl methacrylate) using focused extreme ultraviolet radiation from a table-top laser-induced plasma source (2007)

In order to perform material interaction studies with intense extreme ultraviolet (EUV) radiation, a Schwarzschild mirror objective coated with Mo/Si multilayers was adapted to a compact laser-based EUV plasma source (pulse energy 3 mJ at λ=13.5 nm, plasma diameter ∼300 μm). By 10× demagnified imaging of the plasma a pulse energy density of ∼75 mJ∕cm2 at a pulse length of 6 ns can be achieved in the image plane of the objective. As demonstrated for poly(methyl methacrylate) (PMMA), photoetching of polymer surfaces is possible at this EUV fluence level. This paper presents first results, including a systematic determination of PMMA etching rates under EUV irradiation. Furthermore, the contribution of out-of-band radiation to the surface etching of PMMA was investigated by conducting a diffraction experiment for spectral discrimination from higher wavelength radiation. Imaging of a pinhole positioned behind the plasma accomplished the generation of an EUV spot of 1 μm diameter, which was employed for direct writing of surface structures in PMMA.
Atomic layer deposition of high-<i>κ</i> layers on polycrystalline diamond for MOS devices: a review (2020)

Working in concert, diamond layers and high-<italic>κ</italic> films impart opportunities for high performance MOS devices. Optimization hinges on their interfacial quality inciting investigation into diamond surface terminations and ALD parameters to ensure success.
¿cómo leen y escriben en lengua castellana, los niños del Resguardo Indígena de Guambía? (2010)

The aim of this investigation was to establish the reading and writing performance and competencies of third grade children of an elementary school in the indigenous reservation of Guambia, in Cauca, Colombia. Materials and methods: This investigation was descriptive and quantitative, and also included a transverse analysis. The analysis included a total of 54 children enrolled in third grade. This was a representative sample of the total number of children included in the population. The results obtained showed evidence that most children expressed difficulties in obtaining information from the text to withdraw conclusions. On the other hand, they seemed to have an easier time reading the surface of the text away from a textual production level. They were able to enunciate and to develope the conflicting parts of the reading or text. They did have difficulty developing the end arguments. Also the majority of children were able to maintain the thematic axis of the readings. There was difficulty with thematic progression and with structuring new argument proposals. They presented gender agreement for number utterances in conversation. Finally, the study found that children are completing the construction of the hypothesis alphabetically, causing increased presence of errors in writing. The study concluded that children in these schools were found to be mostly in the literal level of comprehension and textual production, which is not in agreement to the grade level they are placed. Furthermore, in graphic expression specific type errors were omission, hypo or hypersegmentation and substitutions (except for/-o-u-y-uby-/o due to linguistic/dialectical interference).
How important are labor markets to the welfare of the poor in Indonesia (1996)

A majority of the poor in Indonesia come from agricultural and self-employed households. Moreover, the largest single contribution to poverty reduction between 1990 and 1993 came from within-sector welfare gains to self-employed farm households. Data show that the role of the labor market in reducing poverty has increased since the mid-1980s. Wage labor markets can be expected to play an increasingly important impact on the welfare of Indonesia's poor as the economy continues to undergo structural change, and as the workforce moves out of agriculture into manufacturing and services. Because poverty remains largely an agricultural and self-employed phenomenon, the most direct way to reduce poverty is to focus on improving the operation of product, land, and capital markets. At the same time, labor market policy can play an important role in the Government's poverty reduction efforts by helping to facilitate labor mobility across sectors. But if they reduce labor mobility, labor market policies can be counterproductive to Indonesia's poverty reduction efforts. Recent empirical evidence suggests that increases in the minimum wage may have hurt employment growth, particularly among small firms. As such, using minimum wage policy to ensure high wages to a limited number of workers will almost certainly diminish the poverty reducing potential of the labor markets.
Elements of error correction in mitosis: microtubule capture, release, and tension. (1994)

The correction of certain errors in mitosis requires capture and release: new kinetochore microtubules must be captured and old, misdirected ones must be released. We studied capture and release in living grasshopper spermatocytes. Capture is remarkably efficient over a broad range in the angle at which a microtubule encounters a kinetochore. However, capture is inefficient when kinetochores point directly away from the source of properly directed microtubules. Capture in that situation is required for correction of the most common error; microtubule-kinetochore encounters are improbable and capture occurs only once every 8 min, on average. Release from the improper attachment caused by misdirected microtubules allows kinetochore movement and the completion of error correction. We tugged on kinetochores with a micromanipulation needle and found they are free to move less than one time in two. Thus error correction depends on two improbable events, capture and release, and they must happen by chance to coincide. In spermatocytes this will occur only once every 18 min, on average, but a leisurely cell cycle provides ample time. Capture and release generate only change, not perfection. Tension from mitotic forces brings change to a halt by stabilizing the one correct attachment of chromosomes to the spindle. We show that tension directly affects stability, rather than merely constraining kinetochore position. This implies that chromosomes are attached to the spindle by tension-sensitive linkers whose stability is necessary for proper chromosome distribution but whose loss is necessary for the correction of errors.
ø29 DNA Polymerase Residue Ser122, a Single-stranded DNA Ligand for 3′-5′ Exonucleolysis, Is Required to Interact with the Terminal Protein (1998)

Three amino acid residues highly conserved in most proofreading DNA polymerases, a phenylalanine contained in the Exo II motif and a serine and a leucine belonging to the S/TLx2h motif, were recently shown to be critical for 3'-5' exonucleolysis by acting as single-stranded DNA ligands (de Vega, M., Lázaro, J.M., Salas, M. and Blanco, L. (1998) J. Mol. Biol. 279, 807-822). In this paper, site-directed mutants at these three residues were used to analyze their functional importance for the synthetic activities of phi29 DNA polymerase, an enzyme able to start linear phi29 DNA replication using a terminal protein (TP) as primer. Mutations introduced at Phe65, Ser122, and Leu123 residues of phi29 DNA polymerase severely affected the replication capacity of the enzyme. Three mutants, F65S, S122T, and S122N, were strongly affected in their capacity to interact with a DNA primer/template structure, suggesting a dual role during both polymerization and proofreading. Interestingly, mutant S122N was not able to maintain a stable interaction with the TP primer, thus impeding the firsts steps (initiation and transition) of phi29 DNA replication. The involvement of Ser122 in the consecutive binding of TP and DNA is compatible with the finding that the TP/DNA polymerase heterodimer was not able to use a DNA primer/template structure. Assuming a structural conservation among the eukaryotic-type DNA polymerases, a model for the interactions of phi29 DNA polymerase with both TP and DNA primers is presented.
I did not smoke 100 cigarettes today! (2015)

Activity recognition (AR) systems are typically built and evaluated on a predefined set of activities. AR systems work best if the test data contains and only contains these predefined activities. In real world applications, AR systems trained in this manner generate serious false positives, for example if "smoking" is one of the activities in the training data but "lifting weights" is not. Due to the similarity of two activities, an AR system may report a user smoking 100 times a day but he actually did a bicep workout 100 times. In this work, we propose a new approach to train an AR system leveraging the large quantity of unlabeled data which reflects activities users perform in real life. The proposed mPUL (Multi-class Positive and Unlabeled Learning) approach significantly reduces the false positives. We argue that mPUL is a much more effective training method for real-world AR applications.
Microparticle-Enhanced Nephelometric Immunoassay. 1. Measurement of αs-Casein and κ-Casein (1991)

&-Casein and rc-casein were measured in milk and curd by a microparticle-enhanced nephelometric im- munoassay m a @ ' ) . Specifically designed microspheres were coated with antigen (%casein and ~-caseh) and then were agglutinated by specific antibodies. The light scattered by the agglutinates was quantified with a nephelometer. Antigen-coated microsphere agglutination was inhibited by free antigen solution, allowing its measurement. Calibration curves for &casein and K-casein in milk and curd, performed with a low heat milk powder as standard, largely covered the usual concentrations of caseins. Accuracy (average ratios of recovery were 98.7 and 104.3%) and precision (coefficients of variation f?om 1.9 to 7.4%) assessed the fidelity of the method. NEPHELIA~, applied to casein determination, offers many advantages over the classical methods of milk protein measurement: high dilution of the reagents, no pretreatment of the samples, e n h a n d sensitivity (few micrograms
Smallpox antiviral drug development: satisfying the animal efficacy rule (2006)

Concerns over the potential use of variola virus as a biological weapon have prompted new interest in the development of small molecule therapeutics to prevent and treat smallpox infection. Since smallpox is no longer endemic, human clinical trials designed to link antiviral efficacy to clinical outcome have been supplanted by antiviral efficacy evaluations in animal models of orthopoxvirus disease. This poses a unique challenge for drug development; how can animal efficacy data with a surrogate virus be used to establish clinical correlates predictive of human disease outcome? This review will examine the properties of selected animal models that are being used to evaluate poxvirus antiviral drug candidates, and discuss how data from these models can be used to link drug efficacy to clinical correlates of human disease.
Isothermal loop-mediated amplification (lamp) for diagnosis of contagious bovine pleuro-pneumonia (2013)

The CBPP LAMP developed in a robust kit format can be run on a battery-driven mobile device to rapidly detect M. mycoides subsp. mycoides infections from clinical or post mortem samples. The stringent innate quality control allows a conclusive on-site diagnosis of CBPP such as during farm or slaughter house inspections.
Improved automatic testcase synthesis for performance model validation (2005)

Performance simulation tools must be validated during the design process as functional models and early hardware are developed, so that designers can be sure of the performance of their designs as they implement changes. The current state-of-the-art is to use simple hand-coded bandwidth and latency testcases to assess early performance and to calibrate performance models. Applications and benchmark suites such as SPEC CPU are difficult to set up or take too long to execute on functional models. Short trace snippets from applications can be executed on performance and functional simulators, but not without difficulty on hardware, and there is no guarantee that hand-coded tests and short snippets cover the performance of the original applications.We present a new automatic testcase synthesis methodology to address these concerns. By basing testcase synthesis on the workload characteristics of an application, we create source code that largely represents the performance of the application, but which executes in a fraction of the runtime. We synthesize representative versions of the SPEC2000 benchmarks, compile and execute them, and obtain an average IPC within 2.4% of the average IPC of the original benchmarks with similar average workload characteristics. In addition, the changes in IPC due to design changes are found to be proportional to the changes in IPC for the original applications. The synthetic testcases execute more than three orders of magnitude faster than the original applications, typically in less than 300K instructions, making performance model validation feasible.
Large‐scale production of diesel‐like biofuels – process design as an inherent part of microorganism development (2013)

Industrial biotechnology is playing an important role in the transition to a bio-based economy. Currently, however, industrial implementation is still modest, despite the advances made in microorganism development. Given that the fuels and commodity chemicals sectors are characterized by tight economic margins, we propose to address overall process design and efficiency at the start of bioprocess development. While current microorganism development is targeted at product formation and product yield, addressing process design at the start of bioprocess development means that microorganism selection can also be extended to other critical targets for process technology and process scale implementation, such as enhancing cell separation or increasing cell robustness at operating conditions that favor the overall process. In this paper we follow this approach for the microbial production of diesel-like biofuels. We review current microbial routes with both oleaginous and engineered microorganisms. For the routes leading to extracellular production, we identify the process conditions for large scale operation. The process conditions identified are finally translated to microorganism development targets. We show that microorganism development should be directed at anaerobic production, increasing robustness at extreme process conditions and tailoring cell surface properties. All the same time, novel process configurations integrating fermentation and product recovery, cell reuse and low-cost technologies for product separation are mandatory. This review provides a state-of-the-art summary of the latest challenges in large-scale production of diesel-like biofuels.
Effects of proton conduction on dielectric properties of peptides (2018)

Peptides have been overlooked for their use in the field of electronics, even though they are one of the most commonly found bio-induced materials, and are not only easy to mass-produce but also exhibit a high dielectric constant. Additionally, unlike proteins, which are gaining considerable interest with materials researchers, peptides are much simpler, rendering their original characteristics easier to maintain without significant alteration of their structure. On the other hand, proteins tend to deform due to their susceptibility to environmental changes. Combining such superb dielectric properties with their relatively stable nature, peptides could be utilized as a component of electronic devices ranging from basic capacitors to more complex thin-film transistors. In this paper, a peptide chain (YYACAYY) composed of tyrosine, alanine, and cysteine was extensively studied using an impedance analyzer to determine its innate charge movement mechanism in order to extend our understanding of the electric properties of peptides. The movement of mobile protons inside the peptide insulator was found to be the source of the high relative permittivity of the peptide insulator, and the dielectric constant of the peptide insulator was found to be over 17 in humid conditions. By widening the understanding of the dielectric properties of the peptide insulator, it is expected that the peptide can be further utilized as an insulator in various electronic devices.
A programmable security processor for cryptography algorithms (2008)

A novel programmable security processor for cryptography algorithms is presented in this paper. The 16-bit length RISC-like instruction set and 3-stage pipeline provide low code density, low hardware cost and low power consumption. Parallel on-chip lookup tables are integrated to obtain satisfactory performance of cryptographic processing. Chinese wireless local area network block cipher standard-SMS4 and NIST encryption standard-AES are implemented in this processor, and it is the first implementation of SMS4 based on a domain specific programmable processor. To resist external attack on memories, a method for secure storage of round key is also proposed.
Intramolecular Nucleophile-Induced Photorearrangements and Silene Formation from an<i>o</i>-(Methoxymethyl)phenylsilacyclobutane (2003)

Direct photolysis of 1-(o-(methoxymethyl)phenyl)-1-phenylsilacyclobutane yields three isomeric products attributed to intramolecular trapping of an initially formed silicon-carbon biradical intermediate by migration of the benzylic methoxy group to silicon, along with the (expected) intramolecularly ether-stabilized silene due to formal [2 + 2]-cycloreversion.
Assessment of T lymphocyte cytokine production in induced sputum from asthmatics: a flow cytometry study (2003)

IS T cell cytokine production indicates a basic Th2 bias in asthma, accompanied during symptoms by a Th1-like activation. These results open the field for longitudinal studies of the variation of T cell activation in asthma.
Accurate Parametric Modeling of Folded Waveguide Circuits for Millimeter-Wave Traveling Wave Tubes (2005)

In this paper, results of different models are compared for calculating effective, cold-circuit (beam-free) phase velocities and interaction impedances of folded waveguide (FW) slow wave circuits for use in millimeter-wave traveling wave tubes (TWT). These parameters are needed for one-dimensional (1-D) parametric model simulations of FW traveling wave tubes (FWTWTs). The models investigated include approximate analytic expressions, equivalent circuit, three-dimensional (3-D) finite difference, and 3-D finite element. The phase velocity predictions are compared with experimental measurements of a representative FW circuit. The various model results are incorporated into the CHRISTINE1D code to obtain predictions of small signal gain in a 40-55 GHz FWTWT. Comparing simulated and measured frequency-dependent gain provides a sensitive, confirming assessment of the accuracy of the simulation tools. It is determined that the use of parametric 1-D TWT models for accurate, full band predictions of small signal gain in FWTWTs requires knowledge of phase velocity and impedance functions that are accurate to <0.5% and <10%, respectively. Saturated gain predictions, being approximately half as sensitive to these parameters, appear to require correct specification of phase velocity and interaction impedance to within /spl sim/1% and 20%, respectively. Although all models generate sufficiently accurate predictions of the interaction impedance, not all generate sufficiently accurate predictions of the effective axial phase velocity.
A Novel Controlled-Release System for Antibacterial Enzyme Lysostaphin Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement (2014)

In this work, a lysostaphin-loaded, control-released, self-setting and injectable porous bone cement with efficient protein delivery was prepared by a novel setting method using hydroxyapatite/chitosan (HA/CS) composite scaffold. The cement samples were made through cementitious reactions by mixing solid powder, a mixture of HA/CS composite particles, lysostaphin, Ca(OH)2, CaCO3 and NaHCO3, with setting liquid containing citric acid, acetic acid, NaH2PO4, CaCl2 and poloxamer. The setting parameters of the cement samples were determined. The results showed that the final setting time was 96.6±5.2 min and the pH value increased from approximately 6.2 to nearly 10 during the setting process and the porosity was 34% at the end. And the microstructure and composition were detected by scanning electron microscopy (SEM), x-ray diffraction and Fourier transform-infrared spectroscopy. For the release behavior of lysostaphin loaded in the cement sample, the in vitro cement extract experiment indicated that about 94.2±10.9% of the loaded protein was released before day 8 and the in vivo Qdot 625 fluorescence tracking experiment showed that the loaded protein released slower than the free one. Then the biocompatibility of the cement samples was evaluated using the methylthiazol tetrazolium assay, SEM and hematoxylin-eosin staining, which suggested good biocompatibility of cement samples with MC 3T3-E1 cells and subcutaneous tissues of mice. Finally the antibacterial activity assay indicated that the loaded lysostaphin had good release ability and strong antibacterial enzymatic activity against methicillin-resistant Staphylococcus aureus. Collectively, all the results suggested that the lysostaphin-loaded self-setting injectable porous bone cement released the protein in a controlled and effective way and the protein activity was well retained during the setting and releasing process. Thus this bone cement can be potentially applied as a combination of artificial bone substitute and controlled-release system for delivery of lysostaphin to treat bone defects and infections.
Performance of optimized actuator and sensor arrays in an active noise control system (1996)

Experiments have been conducted in NASA Langley's Acoustics and Dynamics Laboratory to determine the effectiveness of optimized actuator/sensor architectures and controller algorithms for active control of harmonic interior noise. Tests were conducted in a large scale fuselage model - a composite cylinder which simulates a commuter class aircraft fuselage with three sections of trim panel and a floor. Using an optimization technique based on the component transfer functions, combinations of 4 out of 8 piezoceramic actuators and 8 out of 462 microphone locations were evaluated against predicted performance. A combinatorial optimization technique called tabu search was employed to select the optimum transducer arrays. Three test frequencies represent the cases of a strong acoustic and strong structural response, a weak acoustic and strong structural response and a strong acoustic and weak structural response. Noise reduction was obtained using a Time Averaged/Gradient Descent (TAGD) controller. Results indicate that the optimization technique successfully predicted best and worst case performance. An enhancement of the TAGD control algorithm was also evaluated. The principal components of the actuator/sensor transfer functions were used in the PC-TAGD controller. The principal components are shown to be independent of each other while providing control as effective as the standard TAGD.