gebhart/patrepeval huggingface dataset:
trans-1-N-Acylamino-1,3-dienes: preparation from dienoic acids (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTtrans-1-N-Acylamino-1,3-dienes: preparation from dienoic acidsLarry E. Overman, Garry F. Taylor, Charles B. Petty, and Peter J. JessupCite this: J. Org. Chem. 1978, 43, 11, 2164–2167Publication Date (Print):May 1, 1978Publication History Published online1 May 2002Published inissue 1 May 1978https://pubs.acs.org/doi/10.1021/jo00405a017https://doi.org/10.1021/jo00405a017research-articleACS PublicationsRequest reuse permissionsArticle Views902Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TWT's in space - present status and future applications (2009)

This paper presents space applications of the TWT from the point of view of the German Space Agency. Technical aspects like high reliability, high efficiency, low mass and long lifetime play an important role as well as space typical factors like small number of pieces qualified designs and short delivery. Typical applications of the different Satellite Services (BSS, FSS, MSS, Data Relay and Navigation) will be discussed as well as the corresponding frequency ranges and power demands. The paper shows the DLR programmatic strategy and will overview the funding and supporting activities of the TWT research and development in the satellite communication department of the German space agency. Most of these new technologies will be qualified in space on the German Heinrich Hertz Satellite Mission as technology verification platform.
Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control (2008)

There exists a unique group of persons who are able to durably control HIV in the absence of therapy. The mechanisms of control in these persons remain poorly defined. In this study, we examined CD8(+) T-cell responses in blood and rectal mucosa from 17 "elite controllers" (viral load < 75 copies/mL), 11 "viremic controllers" (75-2000 copies/mL), 14 noncontrollers (> 10,000 copies/mL), and 10 antiretroviral-treated persons (< 75 copies/mL). Production of interferon-gamma, interleukin-2, tumor necrosis factor-alpha, macrophage inflammatory protein-1 beta, and CD107a by CD8(+) T cells in response to HIV-1 Gag stimulation was measured using flow cytometry. Our hypothesis was that "polyfunctional" T cells producing multiple antiviral factors would be most abundant in mucosal tissues of HIV controllers. Mucosal CD8(+) T-cell responses were significantly stronger and more complex in controllers than in antiretroviral-suppressed persons (P = .0004). The frequency of 4-function responses in rectal mucosa was higher in controllers than in noncontrollers and patients on therapy (P < .0001). Mucosal responses in controllers were frequently stronger and more complex than blood responses. These findings demonstrate that many controllers mount strong, complex HIV-specific T-cell responses in rectal mucosa. These responses may play an important role in mucosal immune surveillance, as suggested by their relative enrichment among persons who control HIV in the absence of therapy.
JandaJel as a polymeric support to improve the catalytic efficiency of immobilized-1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) under solvent-free conditions (2011)

JandaJel, with its greater spacing between the linear polymeric chains compared to that of polystyrene matrices, is a very efficient support for improving the catalytic efficiency of TBD under SolFC.
Immunohistochemistry for Histone H3 Lysine 9 Methyltransferase and Demethylase Proteins in Human Melanomas (2014)

Methylation and demethylation of histone H3 lysine 9 (H3K9) play a role in the transcriptional regulation of several cancer-related genes and are closely associated with malignant tumor behavior. A novel study has recently demonstrated that SETDB1, a member of the H3K9 methyltransferases, accelerates tumor formation significantly in a zebrafish melanoma model. However, the expression of H3K9 methyltransferases including SETDB1 and demethylases has not been systematically examined in samples of human melanoma. Here, we used immunohistochemistry to examine the expression of the H3K9 methyltransferases, EHMT2 and SETDB1, and a H3K9 demethylase, LSD1, in 67 patients with melanoma. Overexpression of EHMT2, SETDB1, and LSD1 was observed in 14 (21%), 38 (57%), and 53 (79%) of the 67 patients, respectively. A significant relationship was observed between overexpression of EHMT2 or SETDB1 and aggressive tumor behavior such as lymph node metastasis and/or distant metastasis (P < 0.05), whereas no significant relationship was evident for LSD1 immunoreactivity. Univariate log-rank tests demonstrated that patients with melanoma overexpressing EHMT2 had a poorer outcome (P < 0.001), whereas overexpression of SETDB1 or LSD1 had no prognostic impact. These results suggest that overexpression of EHMT2 might be a prognostic marker in patients with melanoma.
Nonidealities in traveling wave and transversal FIR filters operating at microwave frequencies (2006)

We examine the effects of transmission-line nonidealities like series loss, terminal impedance mismatch, circuit noise, and transconductor input and output capacitances on the performance of traveling-wave (TWA) and transversal finite-impulse response (FIR) filters. A general framework is presented for the analysis and simulation of such filters in the context of a real communication channel. Simulation results for adaptive equalizers operating at a data rate of 10 Gbps are given. Intuition is derived for the vastly superior performance of TWA-FIR filters. We also show that the effects of series losses can be counteracted in some measure by deliberately misterminating the transmission lines with a resistance lower than their characteristic impedance.
Construction of Two-Dimensional Arrays Gold Nanoparticles Monolayer onto Boron-Doped Diamond Electrode Surfaces (2006)

A novel method has been developed to immobilize macroscopic two-dimensional arrays of Au nanoparticles (AuNPs) onto the surfaces of boron-doped diamond (BDD) electrodes. These AuNP-modified surfaces are prepared by self-assembly of differently sized colloidal Au particles onto the BDD surfaces. A dense and well-distributed AuNP monolayer onto the BDD surfaces was obtained by pretreating the BDD surface with allylamine by photochemical reaction. These modified surfaces have been characterized by XPS, SEM, and electrochemical cyclic voltammetry (CVs). SEM data indicated that the AuNPs are immobilized and well-dispersed, forming a uniform monolayer on the amine-terminated activated BDD surfaces in two dimensions. Cyclic voltammtric (CV) results indicate that the immobilized AuNPs monolayer onto BDD electrode shows excellent electrochemical properties, implying facile electrochemical communication between the AuNPs monolayer and BDD substrate through the amine linkers.
Modulation of the Photophysical Properties of Curcumin in Nonionic Surfactant (Tween-20) Forming Micelles and Niosomes: A Comparative Study of Different Microenvironments (2013)

The modulation of the photophysical properties of curcumin inside two different types of microenvironments provided by nonionic surfactant forming micelles and vesicles (niosomes) has been investigated using steady state and time-resolved fluorescence spectroscopy. The formation of small unilamellar Tween-20/cholesterol niosomes with narrow size distribution has been successfully demonstrated by means of dynamic light scattering (DLS) and transmission electron microscopy (TEM) techniques. Our results indicate that niosomes are a better possible delivery system than the conventional surfactants forming normal micelles to suppress the level of degradation of curcumin. The enhanced fluorescence intensity along with the significant blue-shift in the emission maxima of curcumin upon encapsulation into the hydrophobic microenvironments of micelles and niosomes is a consequence of the reduced interaction of curcumin with the water molecules. We found that the more rigid and confined microenvironment of niosomes enhances the steady state fluorescence intensity along with the fluorescence lifetime of curcumin more than in micelles. The rigidity of the niosome membrane which arises basically due to the presence of cholesterol molecules increases the level of interaction between curcumin and the oxoethylene units of Tween-20 molecules. It is also possible for the hydroxyl groups of the cholesterol moieties to form intermolecular hydrogen bonds with curcumin to perturb nonradiative deactivation mechanism through excited state intramolecular hydrogen atom transfer (ESIHT).
Structural and Biochemical Evidence for an Enzymatic Quinone Redox Cycle in Escherichia coli (2004)

Naturally synthesized quinones perform a variety of important cellular functions. Escherichia coli produce both ubiquinone and menaquinone, which are involved in electron transport. However, semiquinone intermediates produced during the one-electron reduction of these compounds, as well as through auto-oxidation of the hydroxyquinone product, generate reactive oxygen species that stress the cell. Here, we present the crystal structure of YgiN, a protein of hitherto unknown function. The three-dimensional fold of YgiN is similar to that of ActVA-Orf6 monooxygenase, which acts on hydroxyquinone substrates. YgiN shares a promoter with "modulator of drug activity B," a protein with activity similar to that of mammalian DT-diaphorase capable of reducing mendione. YgiN was able to reoxidize menadiol, the product of the "modulator of drug activity B" (MdaB) enzymatic reaction. We therefore refer to YgiN as quinol monooxygenase. Modulator of drug activity B is reported to be involved in the protection of cells from reactive oxygen species formed during single electron oxidation and reduction reactions. The enzymatic activities, together with the structural characterization of YgiN, lend evidence to the possible existence of a novel quinone redox cycle in E. coli.
Object-oriented data warehouse for information fusion from heterogeneous distributed data and knowledge sources (2002)

Tools for accessing, transforming, organizing and assimilating data and knowledge from multiple heterogeneous, distributed data and knowledge sources in a form that is suitable for further analysis constitute some of the key enabling technologies for translating recent advances in automated data acquisition, digital storage, computers and communications into fundamental advances in organizational decision support, data analysis, and related applications. The design, implementation, and evaluation of a data warehouse using object-oriented views and mediator agents for bridging the mismatch between data sources and clients has been a major focus of research as part of the Distributed Knowledge Networks Project at the Iowa State University Artificial Intelligence Research Laboratory over the past two years. This paper describes the design, implementation, and population of a data warehouse component of distributed knowledge networks.
i‐vector representation based on bottleneck features for language identification (2013)

An i‐vector representation based on bottleneck (BN) features is presented for language identification (LID). In the proposed system, the BN features are extracted from a deep neural network, which can effectively mine the contextual information embedded in speech frames. The i‐vector representation of each utterance is then obtained by applying a total variability approach on the BN features. The resulting performance of LID has been significantly improved with the proposed BN feature based i‐vector representation. Compared with the state‐of‐the‐art techniques, the equal error rate is relatively reduced by about 40% on the National Institute of Standards and Technology (NIST) 2009 evaluation sets.
Maximum likelihood multiple projection schemes for hidden Markov models (1999)

In many complex pattern recognition tasks the choice of a \\good&quot; feature space in which to model the data varies depending on the signal content. Multiple feature subspaces can be used, for example phone dependent subspaces in speech recognition. Handling multiple subspaces whilst still maintaining meaningful likelihood comparisons between classes is a complex problem. This paper views this multiple projection problem in a maximum likelihood framework. Two forms of multiple projection schemes are described in terms of tying a standard semi-tied covariance matrix system. The rst results in model complexity control over the dimensions, whilst selecting the appropriate feature space for that complexity. The second may be viewed as a simultaneous projection and optimisation of a set of semi-tied transforms. These two schemes are compared on a large vocabulary task. Varying the complexity over the dimension was found to slightly increase speed and reduce model size without degrading the pe...
Serum Tumor Necrosis Factor-α and Interleukin-10 Levels as Markers to Predict Outcome of Patients with Chronic Lymphocytic Leukemia in Different Risk Groups Defined by the IGHV Mutation Status (2012)

Tumor necrosis factor (TNF)-α and interleukin (IL)-10 are cytokines involved in the balance between cell-mediated and humoral immunity. We investigated whether serum TNF-α and IL-10 levels have any impact on clinical outcome of patients with chronic lymphocytic leukemia (CLL). TNF-α and IL-10 levels were determined in the serum of 160 CLL patients at the time of diagnosis. The cytokine low-risk group consisted of patients with either TNF-α and IL-10 levels below their medians or those with only one elevated parameter. Both TNF-α and IL-10 levels greater than or equal to their medians defined the cytokine high-risk group. The high-risk patients presented a shorter 3-year treatment-free survival (TFS) than low-risk subjects (15 vs. 69.6 %; p < 0.0001). The high-risk group (p = 0.0002) along with high leukocyte count (p < 0.0001) and unmutated immunoglobulin heavy-chain variable region genes (p < 0.0001) independently predict the risk of progression in patients with Rai stage 0-II. Furthermore, the high-risk group had an independent prognostic impact on shorter TFS both in patients with mutated (24.3 vs. 78.2 %; p < 0.0001) and unmutated (8.2 vs. 49 %; p = 0.004) immunoglobulin heavy-chain variable region genes (IGHV) as compared to the low-risk group. The estimated 5-year overall survival (OS) of high-risk patients was shorter than those in the low-risk group (83.3 vs. 97.1 %; p = 0.003). Multivariate analysis demonstrated the cytokine high-risk group (p = 0.02) followed by Rai stage III-IV (p = 0.048) to be independent factors predicting shorter OS. At diagnosis, TNF-α and IL-10 may predict the outcome of patients with CLL.
Job-Site Level Fault Tolerance for Cluster and Grid environments (2005)

In order to adopt high performance clusters and grid computing for mission critical applications, fault tolerance is a necessity. Common fault tolerance techniques in distributed systems are normally achieved with checkpoint-recovery and job replication on alternative resources, in cases of a system outage. The first approach depends on the system's MTTR while the latter approach depends on the availability of alternative sites to run replicas. There is a need for complementing these approaches by proactively handling failures at a job-site level, ensuring the system high availability with no loss of user submitted jobs. This paper discusses a novel fault tolerance technique that enables the job-site recovery in Beowulf cluster-based grid environments, whereas existing techniques give up a failed system by seeking alternative resources. Our results suggest sizable aggregate performance improvement during an implementation of our method in Globus-enabled HA-OSCAR. The technique called ''smart failover" provides a transparent and graceful recovery mechanism that saves job states in a local job-manager queue and transfers those states to the backup server periodically, and in critical system events. Thus whenever a failover occurs, the backup server is able to restart the jobs from their last saved state
Functional and Morphologic Characterizations of the Diabetic Mouse Corpus Cavernosum: Comparison of a Multiple Low-Dose and a Single High-Dose Streptozotocin Protocols (2009)

The mouse model of type I diabetes is useful and technically feasible for the study of the pathophysiologic mechanisms involved in diabetic erectile dysfunction.
Dosimetry of extremely-low-frequency magnetic fields (1992)

Extrapolation of quantitative measurements across biological systems requires knowledge of field-organism interaction mechanisms. In the absence of such knowledge, one can only indicate which parameters would be important under some plausible assumptions that still lack experimental proof. In the first part of the paper it is assumed that biological effects of low intensity, extremely low frequency magnetic fields are caused by the electric fields which they induce. It is shown that detailed knowledge of electrical properties on a microscale is important to predict effects that may be due to local current density, electric field strength, surface charge distribution, and mechanical forces. In the second part of the paper, it is shown that all proposed mechanisms for direct interaction between alternating magnetic fields and cells involve also the magnitude and direction of a simultaneously present static magnetic field. Reviewed are "cyclotron resonance," quantum mechanical effects on ions weakly bound to proteins, nuclear magnetic resonance, and recent progress in magneto chemistry dealing with effects of magnetic fields of a few hundred microtesla on chemical reactions that involve free radicals.
Model-Driven Feedforward Prediction for Manipulation of Deformable Objects (2018)

Robotic manipulation of deformable objects is a difficult problem especially because of the complexity of the many different ways an object can deform. Searching such a high-dimensional state space makes it difficult to recognize, track, and manipulate deformable objects. In this paper, we introduce a predictive, model-driven approach to address this challenge, using a precomputed, simulated database of deformable object models. Mesh models of common deformable garments are simulated with the garments picked up in multiple different poses under gravity, and stored in a database for fast and efficient retrieval. To validate this approach, we developed a comprehensive pipeline for manipulating clothing as in a typical laundry task. First, the database is used for category and the pose estimation is used for a garment in an arbitrary position. A fully featured 3-D model of the garment is constructed in real time, and volumetric features are then used to obtain the most similar model in the database to predict the object category and pose. Second, the database can significantly benefit the manipulation of deformable objects via nonrigid registration, providing accurate correspondences between the reconstructed object model and the database models. Third, the accurate model simulation can also be used to optimize the trajectories for the manipulation of deformable objects, such as the folding of garments. Extensive experimental results are shown for the above tasks using a variety of different clothings. Note to Practitioners-This paper provides an open source, extensible, 3-D database for dissemination to the robotics and graphics communities. Model-driven methods are proliferating, and they need to be applied, tested, and validated in real environments. A key idea we have exploited is to have an innovative and novel use of simulation. This database will serve as infrastructure for developing advanced robotic machine learning algorithms. We want to address this machine learning idea ourselves, but we expect the dissemination of the database to other researchers with different agendas and task applications, which will bring wide progress in this area. Our proposed methods, as mentioned earlier, can be easily applied to interrelated areas. One example is that the 3-D shape-based matching algorithm can be used for other objects, such as bottles, papers, and food. After integrating with other robotic systems, the use of the robot can be easily extended to other tasks, such as making food, cleaning room, and fetching objects, to assist our daily life.
Rapidly-Deposited Polydopamine Coating via High Temperature and Vigorous Stirring: Formation, Characterization and Biofunctional Evaluation (2014)

Polydopamine (PDA) coating provides a promising approach for immobilization of biomolecules onto almost all kinds of solid substrates. However, the deposition kinetics of PDA coating as a function of temperature and reaction method is not well elucidated. Since dopamine self-polymerization usually takes a long time, therefore, rapid-formation of PDA film becomes imperative for surface modification of biomaterials and medical devices. In the present study, a practical method for preparation of rapidly-deposited PDA coating was developed using a uniquely designed device, and the kinetics of dopamine self-polymerization was investigated by QCM sensor system. It was found that high temperature and vigorous stirring could dramatically speed up the formation of PDA film on QCM chip surface. Surface characterization, BSA binding study, cell viability assay and antibacterial test demonstrates that the polydopamine coating after polymerization for 30 min by our approach exhibits similar properties to those of 24 h counterpart. The method has a great potential for rapid-deposition of polydopamine films to modify biomaterial surfaces.
Block diagram compilation and graphical editing of DSP algorithms in the QuickSig system (2003)

The QuickSig system is an experimental integrated software environment for digital signal processing, based on the use of the Common Lisp language and object-oriented programming. The authors describe the approach of using a block diagram compiler and an interactive graphical editor in digital signal processor software development. The object-oriented approach on the Common Lisp language is well suited to the problem due to its flexibility in terms of manipulating symbolic expressions and object structures. The system compiles an efficient Lisp code from block diagram descriptions and is able to use different strategies and styles of code generation. Possible extensions to the system, e.g. the generation of code for signal processor chips, are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>