gebhart/patrepeval huggingface dataset:
Automated extraction of expert knowledge in analog topology selection and sizing (2008)

This paper presents a methodology for analog designers to maintain their insights into the relationship among performance specifications, topology choice, and sizing variables, despite those insights being constantly challenged by changing process nodes and new specs. The methodology is to take a data-mining perspective on a Pareto Optimal Set of sized analog circuit topologies, then doing: extraction of a specs-to-topology decision tree; global nonlinear sensitivity analysis on topology and sizing variables; and determining analytical expressions of performance tradeoffs. These approaches are all complementary as they answer different designer questions. Once the knowledge is extracted, it can be readily distributed to help other designers, without needing further synthesis. Results are shown for operational amplifier design on a database containing thousands of Pareto Optimal designs across five objectives.
VASTA: A Vision and Language-assisted Smartphone Task Automation System (2019)

We present VASTA, a novel vision and language-assisted Programming By Demonstration (PBD) system for smartphone task automation. Development of a robust PBD automation system requires overcoming three key challenges: first, how to make a particular demonstration robust to positional and visual changes in the user interface (UI) elements; secondly, how to recognize changes in the automation parameters to make the demonstration as generalizable as possible; and thirdly, how to recognize from the user utterance what automation the user wishes to carry out. To address the first challenge, VASTA leverages state-of-the-art computer vision techniques, including object detection and optical character recognition, to accurately label interactions demonstrated by a user, without relying on the underlying UI structures. To address the second and third challenges, VASTA takes advantage of advanced natural language understanding algorithms for analyzing the user utterance to trigger the VASTA automation scripts, and to determine the automation parameters for generalization. We run an initial user study that demonstrates the effectiveness of VASTA at clustering user utterances, understanding changes in the automation parameters, detecting desired UI elements, and, most importantly, automating various tasks. A demo video of the system is available here: http://y2u.be/kr2xE-FixjI
Higher-Order Function Networks for Learning Composable 3D Object Representations (2019)

We present a new approach to 3D object representation where a neural network encodes the geometry of an object directly into the weights and biases of a second 'mapping' network. This mapping network can be used to reconstruct an object by applying its encoded transformation to points randomly sampled from a simple geometric space, such as the unit sphere. We study the effectiveness of our method through various experiments on subsets of the ShapeNet dataset. We find that the proposed approach can reconstruct encoded objects with accuracy equal to or exceeding state-of-the-art methods with orders of magnitude fewer parameters. Our smallest mapping network has only about 7000 parameters and shows reconstruction quality on par with state-of-the-art object decoder architectures with millions of parameters. Further experiments on feature mixing through the composition of learned functions show that the encoding captures a meaningful subspace of objects.
Arousal of mucosal secretory immunoglobulin A antitoxin in rats immunized with Escherichia coli heat-labile enterotoxin (1982)

Specific serum and mucosal antitoxin levels were determined by enzyme-linked immunosorbent assays in rats immunized with Escherichia coli heat-labile enterotoxin (LT). Immunization by means of a parenteral prime followed by peroral boosts was the only approach that aroused titers of both serum immunoglobulin G (IgG) antitoxin and mucosal secretory IgA antitoxin that were increased fourfold or more over control values. Primary parenteral immunization was effective when given either intraperitoneally or subcutaneously with either Freund complete adjuvant or alum as the adjuvant. The magnitude of the nucosal secretory IgA antitoxin response and the degree of protection against challenge with either LT or viable LT-producing organisms were related to the number and dosage of peroral boosts. LT antigenicity, as determined by enzyme-linked immunosorbent assay, was progressively reduced by toxoiding it with increasing amounts of glutaraldehyde or a carbodiimide; when LT antigenicity was reduced by greater than 50%, the effectiveness of the toxoid in stimulating mucosal antitoxin and providing protection was compromised. Strong protection extended for more than 6 weeks only in rats immunized with a sufficient peroral dosage of LT to arouse mucosal secretory IgA antitoxin titers at least fourfold greater than those of controls. These observations indicate that the ability of LT to stimulate a mucosal secretory IgA antitoxin response is dependent on the antigenicity, route, and dosage of this immunogen; they suggest that the duration of protection in animals immunized by the peroral route is related to the extent of arousal of mucosal secretory IgA antitoxin.
Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides (2016)

Phenotypic whole-cell screening in erythrocytic cocultures of Plasmodium falciparum identified a series of dihydroisoquinolones that possessed potent antimalarial activity against multiple resistant strains of P. falciparum in vitro and show no cytotoxicity to mammalian cells. Systematic structure-activity studies revealed relationships between potency and modifications at N-2, C-3, and C-4. Careful structure-property relationship studies, coupled with studies of metabolism, addressed the poor aqueous solubility and metabolic vulnerability, as well as potential toxicological effects, inherent in the more potent primary screening hits such as 10b. Analogues 13h and 13i, with structural modifications at each site, were shown to possess excellent antimalarial activity in vivo. The (+)-(3S,4S) enantiomer of 13i and similar analogues were identified as the more potent. On the basis of these studies, we have selected (+)-13i for further study as a preclinical candidate.
Simultaneous Determination of Average Direction of Molecular Orientation and Effective Second Order Nonlinear Optical Constant (|<i>d</i><sup> eff</sup>|) by Phase Measurements of Second Harmonic Generation (2001)

We present a new analytical method of molecular orientation in films using a phase measurement of second harmonic generation (SHG) with a theoretical curve fitting. The new analytical method provides the average direction of molecules and the absolute value of the effective second-order nonlinear optical constant (|d eff|) simultaneously. In conventional methods, the average direction of molecules in a sample has been relatively determined with that in a standard sample having preknown molecular direction. The second harmonic (SH) interference fringe obtained between a reference having preknown molecular direction and the sample has been compared with that between the reference and the standard sample. In the new method, however, the average direction of molecules can be obtained without the standard sample. The value of |d eff| is calculated through the fitting process, the average direction of molecules is determined by the sign or the phase of d eff, which is introduced by a reference. Complete expression with physical meanings is given for the valley points and the contrast of SH interference fringe. There, effect of a lens to focus a fundamental wave to a sample is also taken into account. The new phase measurement of SHG with the curve fitting has been carried out with poled poly(methyl methacrylate) films doped with 2 wt % of p-nitroaniline (PNA/PMMA), which were used as a reference and also as a sample. The accuracy of the new method has been demonstrated in comparison of the value |d eff| of the sample with that determined by Maker fringe measurement. The determined average direction of molecules for the sample was confirmed by experimental geometry of the reference and the sample and also from the poling geometry for the sample. We have shown that the phase measurement of SHG and the curve fitting are useful tools to investigate the molecular orientation.
Kinetics and structural evolution of sorbents at high temperatures. Final report, September 1, 1994--February 29, 1996 (1996)

The focus of this project is on furnace sorbent injection technology using dry calcium-based sorbents for the flue gas desulfurization. The goal is to provide fundamental research kinetics and effects of sorbent properties, aimed at improving SO{sub 2} removal and increasing sorbent utilization in a cost-effective manner. The fifth year project work has been carried out in two phases: (1) modified sorbent studies to understand the influence of sorbent modifications (both physical and chemical) on reaction mechanisms, and (2) development of a comprehensive sulfation model to interpret and predict short-time simultaneous calcination, sulfation and sintering processes. This report discusses these two phases of research.
Parallel and Dynamic Searchable Symmetric Encryption. (2013)

Abstract. Searchable symmetric encryption (SSE) enables a client to outsource a collection of encrypted documents in the cloud and retain the ability to perform keyword searches without revealing information about the contents of the documents and queries. Although efficient SSE constructions are known, previous solutions are highly sequential. This is mainly due to the fact that, currently, the only method for achieving sub-linear time search is the inverted index approach (Curtmola, Garay, Kamara and Ostrovsky, CCS ’06) which requires the search algorithm to access a sequence of memory locations, each of which is unpredictable and stored at the previous location in the sequence. Motivated by advances in multi-core architectures, we present a new method for constructing sub-linear SSE schemes. Our approach is highly parallelizable and dynamic. With roughly a logarithmic number of cores in place, searches for a keyword w in our scheme execute in o(r) parallel time, where r is the number of documents containing keyword w (with more cores, this bound can go down to O(log n), i.e., independent of the result size r). Such time complexity outperforms the optimal Θ(r) sequential search time—a similar bound holds for the updates. Our scheme also achieves the following important properties: (a) it enjoys a strong notion of security, namely security against adaptive chosen-keyword attacks; (b) compared to existing sub-linear dynamic SSE schemes (e.g., Kamara, Papamanthou, Roeder, CCS ’12), updates in our scheme do not leak any information, apart from information that can be inferred from previous search tokens; (c) it can be implemented efficiently in external memory (with logarithmic I/O overhead). Our technique is simple and uses a red-black tree data structure; its security is proven in the random oracle model. 1
Glyoxylic Acid Production Using Microbial Transformant Catalysts (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlyoxylic Acid Production Using Microbial Transformant CatalystsJohn E. Gavagan, Susan K. Fager, John E. Seip, Mark S. Payne, David L. Anton, and Robert DiCosimoCite this: J. Org. Chem. 1995, 60, 13, 3957–3963Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jo00118a009https://doi.org/10.1021/jo00118a009research-articleACS PublicationsRequest reuse permissionsArticle Views462Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A New Intact Immunoglobulin for Intravenous Use Stabilized by Chemically Modified Gelatin Derivatives (1986)

The stabilization of human immunoglobulin (IgG) by chemically modified gelatins (Haemaccel and Gelofusine) was investigated. The gelatins prevented IgG from aggregation induced by exposure to interfaces and lyophilization. The stabilization effects of the gelatins were significantly larger than those of amino acids or sugars. These investigations led to the large-scale production of an immunoglobulin preparation for intravenous use in the clinic. The clinical product meets the Japanese minimum requirements for immunoglobulin preparations for intravenous use, and the long-term preservation of this new freeze-dried preparation has demonstrated its stability.
Analysis of Heptachlor and Related Cyclodiene Insecticides in Food Products (1990)

A rapid, competition immunoassay has been developed that detects chlorinated cyclodiene insecticides in meat, fish and milk products. The assay, a competition enzyme-linked immunosorbent assay, employs a monoclonal antibody that recognized all of the cyclodiene insecticides it was tested against. A simple method to extract heptachlor and related cyclodiene insecticides that is compatable with the immunoassay is described. The sensitivity of the immunoassay is sufficent to detect cyclodienes at the tolerance level in beef. We anticipate initial application of this assay as a screening aid.
Design of a vibration energy harvester with two close resonant frequencies (2022)

We present the design of a piezoelectric cantilever with a L-shaped proof mass and multiples electrodes allowing vibration energy harvesting at two close frequencies. Indeed, the resonant frequencies of the proposed harvester are 35.3 Hz and 53.2 Hz for the first and second bending modes, respectively. Based on a study of the strain distribution with an analytical model, we provide design guidelines for the electrodes’ configuration to maximize the electromechanical coupling coefficients $k^{2}$ of a PZT-based harvester. When the electrodes are judiciously connected, the coefficient $k^{2}$ reaches 9.3 % for the first mode and 8.1 % for the second mode, allowing 3 Hz (8.4 %) and 3.5 Hz (6.5 %) frequency bandwidths with resistive frequency tuning respectively.
Digital predistortion using direct learning with reduced bandwidth feedback (2013)

Digital predistortion (DPD) is a popular approach for linearizing power amplifiers (PAs) in wireless base stations and improving system efficiency. The feedback path in a DPD system typically requires 5x signal bandwidth to accommodate the bandwidth expansion caused by the DPD and nonlinear PA. In this paper, we propose a new approach for adapting DPD parameters using direct learning and reduced bandwidth feedback. The new approach is capable of achieving near full-rate DPD performance and linearization bandwidth with significantly reduced feedback bandwidth. Measurement results on a Doherty PA achieved more than 20 dB corrections over 200 MHz bandwidth for a 2-carrier WCDMA signal spanning 40 MHz with only 81.92 MHz feedback bandwidth.
Gamma irradiating chromatography columns enables bioburden‐free integrated continuous biomanufacturing (2020)

An important consideration for integrated continuous biomanufacturing is that the downstream chromatography steps integrated with the bioreactor should maintain a low bioburden state throughout the entire duration of the operation. One potential strategy to achieve this is to start bioburden-free and functionally close the chromatography system. While chromatography skids themselves can be rendered bioburden-free, limitations exist in applying these methods to chromatography columns. The small column sizes used in continuous multicolumn chromatography enable gamma irradiation of disposable columns to render them bioburden-free. However, this approach has not been widely implemented, likely because gamma irradiation can negatively impact resin performance. Here, several protective mobile-phase modifiers were screened and shown to help chromatography resins retain naïve-like performance. Gamma irradiated columns were then integrated into perfusion bioreactors for continuous capture. Successful integrated continuous capture downstream of perfusion bioreactors for greater than 40 days using protein A, custom affinity, and non-affinity capture resins for multiple biologic modalities is demonstrated in development and commercial settings. No indications of time-based performance decline or bioburden growth have been observed. This strategy enables bioburden-free integrated continuous biomanufacturing operations and could allow full process closure and decreased environmental control requirements for facilities; thus, permitting simultaneous multi-product operations in a ballroom arrangement.
Differential Diagnosis of Normal Pressure Hydrocephalus by MRI Mean Diffusivity Histogram Analysis (2012)

BACKGROUND AND PURPOSE: Accurate diagnosis of normal pressure hydrocephalus is challenging because the clinical symptoms and radiographic appearance of NPH often overlap those of other conditions, including age-related neurodegenerative disorders such as Alzheimer and Parkinson diseases. We hypothesized that radiologic differences between NPH and AD/PD can be characterized by a robust and objective MR imaging DTI technique that does not require intersubject image registration or operator-defined regions of interest, thus avoiding many pitfalls common in DTI methods.
Real-time normalization and nonlinearity evaluation methods of the PGC-arctan demodulation in an EOM-based sinusoidal phase modulating interferometer (2018)

In order to reduce the nonlinearity caused by an error of phase modulation depth, carrier phase delay and non-ideal performance of the low pass filters in the sinusoidal phase modulating interferometer (SPMI), a modified EOM-based SPMI is proposed in this paper to realize real-time normalization of the quadrature components for the arctangent approach of phase generated carrier (PGC-Arctan) demodulation. To verify the effectiveness of the real-time normalization technique, a fixed-phase-difference detection method is presented to evaluate the periodic nonlinearity in real time. The modified EOM-based SPMI is consisted of a monitor interferometer and a probe interferometer. The two interferometers share a reference corner cube, which is mounted on a slowly moving stage, thus periodic interference signals are generated for real-time normalization of the quadrature components in PGC demodulation. Subtracting the demodulated phase of the monitor interferometer from the phase of the probe interferometer, the phase to be measured can be obtained. The fixed-phase-difference detection method is realized by detecting an interference signal with two photodetectors, which are placed at an interval of quarter fringe, and the variation of the fixed-phase-difference can reflect the nonlinear error in PGC demodulation. Experiments of real-time normalization, nonlinear error evaluation of PGC demodulation, and displacement measurement were implemented to demonstrate the effectiveness of the proposed method. Experimental results show that the nonlinear error of phase demodulation reduced to less than ± 1° with real-time normalization, and nanometer displacement measurement is realized.
Atmosphere-Ionosphere Response to the M9 Tohoku Earthquake Revealed by Joined Satellite and Ground Observations. Preliminary results (2011)

The recent M9 Tohoku Japan earthquake of March 11, 2011 was the largest recorded earthquake ever to hit this nation. We retrospectively analyzed the temporal and spatial variations of four different physical parameters - outgoing long wave radiation (OLR), GPS/TEC, Low-Earth orbit tomography and critical frequency foF2. These changes characterize the state of the atmosphere and ionosphere several days before the onset of this earthquake. Our first results show that on March 8th a rapid increase of emitted infrared radiation was observed from the satellite data and an anomaly developed near the epicenter. The GPS/TEC data indicate an increase and variation in electron density reaching a maximum value on March 8. Starting on this day in the lower ionospheric there was also confirmed an abnormal TEC variation over the epicenter. From March 3-11 a large increase in electron concentration was recorded at all four Japanese ground based ionosondes, which return to normal after the main earthquake. We found a positive correlation between the atmospheric and ionospheric anomalies and the Tohoku earthquake. This study may lead to a better understanding of the response of the atmosphere /ionosphere to the Great Tohoku earthquake
Phosphorus Removal by Struvite Crystallization in Various Livestock Wastewaters (2007)

Large dairies and swine farms using flush systems for animal waste management face increasing restrictions on over-application of phosphorus to cropland. The wastewater that the flush systems produce contains phosphorus, and is stored in lagoons for recycling in the flush system and for irrigation onto the cropland. Dairy wastewater in some cases in treated in digesters in concentrated form to produce biogas and reduce odor before being irrigated onto cropland. Struvite crystallization has been proposed for reducing the phosphorus content. The current study compares characteristics of three different wastewaters and relates them to differing phosphorus removal results achieved in applying a cone-shaped fluidized-bed struvite crystallizer system to the wastewaters. The three wastewaters were (1) swine lagoon wastewater; (2) dairy lagoon wastewater; and (3) dairy digester effluent.
A Novel Phosphopolysaccharide from Slime-Forming Lactococcus lactis subspecies cremoris SBT 0495 (1990)

Slime-fomring Lactococcus lactis ssp. cremoris SBT 0495 was isolated from starter culture of Finnish fennented milk "Villi". The slime material, which was obtained (yield of 500 mgIL) from culture supernatant in whey penneate medium, contained 42% carbohydrate and 21% protein. Separation of polysaccharide and protein by anion-exchange chromatography was insufficient. Preparative SDS-PAGE was more effective. The purified polysaccharide (150 mgIL culture broth) contained less than .5% protein. It consisted of carbohydrate and phosphorus in a molar ratio of 5.2:1. Rhamnose, glucose, and galactose were found in a molar ratio of 1:1.45:1.75. Sialic acid, hexosamine, and uronic acid were not detected. Apparent molecular weight was estimated to be 1.7 x 1()6 by gel penneation chromatography. Thus, we concluded that the main component in the slime was a novel phosphopolysaccharide (phosphorus-<:ontaining polysaccharide).
NZTM (2009)

This paper introduces NZTM, a nonblocking, zero-indirection, object-based, hybrid transactional memory system. NZTM comprises a nonblocking software transactional memory (STM) system that can exploit best-effort hardware transactional memory (HTM) if available to improve performance.