gebhart/patrepeval huggingface dataset:
Dynamic visualization of surface acoustic waves on a two-dimensional phononic crystal (2009)

Surface acoustic wave propagation on a microscopic two-dimensional phononic crystal consisting of a square lattice of holes is imaged in two dimensions and in real time at frequencies up to 1 GHz by means of pulsed ultrashort optical excitation and detection. The acoustic dispersion relation obtained by spatiotemporal Fourier transforms shows the opening of stop bands at the zone boundaries for surface waves traveling parallel to the phononic crystal axes. We detect pronounced Bloch harmonics above the stop band, and reveal the spatial mode distributions at different frequencies. We also observe phonon collimation for frequencies at which the constant-frequency surfaces become square in shape.
Use of Anticholinergic Drugs and Cholinesterase Inhibitors and Their Association with Psychological Well-Being Among Frail Older Adults in Residential Care Facilities (2011)

Concomitant use of anticholinergic drugs and ChEIs is common among older adults. The use of anticholinergic drugs is associated with poor psychological well-being.
Real-time RNN-based acoustic thermometry with feedback control (2017)

A major obstacle to the widespread adoption of HIFU therapy is the development of a suitable method of monitoring the a blation therapy in real-time. While MR-thermometry has emerged as a promising method for HIFU therapy monitoring, acoustic guidance has continuously been sought for reasons of cost and practicality. We have previously demonstrated the potential of acoustic thermometry, by using a recurrent neural network (RNN) to estimate changes in tissue temperature during HIFU ablation therapies. A limitation of this method is that an excessive therapeutic dose can cause multiple, non-linear changes within the ultrasound data, resulting in unreliable temperature estimates from the RNN. Accordingly, we propose a revised method of dosing wherein closed loop feedback is used to provide a controlled and specific dose; not only to ensure an efficacious lesion, but also to preserve the integrity of the ultrasound image, thereby producing accurate temperature estimates from the RNN. This investigation of con...
The functional morphology of the petioles of the banana, Musa textilis (2000)

Bananas are among the largest herbs in the world and their lightweight petioles hold up huge leaves. This study examined how the petioles manage to achieve adequate rigidity to do this, while allowing extensive and reversible reconfiguration in high winds. Morphological and anatomical examination of the petioles and leaves of Musa textilis suggested how these two apparently incompatible abilities are achieved. The hollow U-shaped section of the petiole and the longitudinal strengthening elements in its outer skin give it adequate rigidity, while its ventral curvature help support the leaf without the need for thick lateral veins. These features, however, also allow the petiole to reconfigure by twisting away from the wind, while the leaf can fold away. In addition, two sets of internal structures, longitudinal partitions and transverse stellate parenchyma plates, help prevent dorsoventral flattening, allowing the petiole to flex further away from the wind without buckling. These ideas were tested and verified by a range of mechanical tests. Simple four-point-bending and torsion tests showed that the petioles are indeed far more compliant in torsion than in bending. Axial bending tests and crushing tests showed that petioles could be flexed twice as far and were four times as resistant to dorsoventral flattening when intact than when the internal tissue is removed. The banana petiole, therefore, seems to be an excellent example of natural integrated mechanical design.
Clinical Metabolomics: The New Metabolic Window for Inborn Errors of Metabolism Investigations in the Post-Genomic Era (2016)

Inborn errors of metabolism (IEM) represent a group of about 500 rare genetic diseases with an overall estimated incidence of 1/2500. The diversity of metabolic pathways involved explains the difficulties in establishing their diagnosis. However, early diagnosis is usually mandatory for successful treatment. Given the considerable clinical overlap between some inborn errors, biochemical and molecular tests are crucial in making a diagnosis. Conventional biological diagnosis procedures are based on a time-consuming series of sequential and segmented biochemical tests. The rise of "omic" technologies offers holistic views of the basic molecules that build a biological system at different levels. Metabolomics is the most recent "omic" technology based on biochemical characterization of metabolites and their changes related to genetic and environmental factors. This review addresses the principles underlying metabolomics technologies that allow them to comprehensively assess an individual biochemical profile and their reported applications for IEM investigations in the precision medicine era.
Methodological Concerns Regarding Cost-effectiveness Analysis of Palivizumab in Florida Medicaid (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Energy-Efficient Scheduling for Multiple Latency-Sensitive Bluetooth Low Energy Nodes (2017)

Energy-efficient scheduling in wireless embedded devices is a critical consideration due to limited energy supplies and the latency constraint of sensory data processing. Bluetooth low energy (BLE) is a low power solution that provides a user-defined connection interval parameter for extending the sleep time of BLE nodes. Instead of minimizing the values for this connection parameter to minimize latency, which can lead to excessive energy consumption, this paper presents a practical energy-efficient scheduling framework for multiple BLE devices having applications with latency constraints. First, we determine the required connection interval for a single BLE node with multi-rate sensing applications. Then, considering the scheduling issues caused by non-preemptive data transmission, we present an energy-efficient connection interval assignment for a sensor network with multiple BLE nodes to meet the latency constraints of sensing applications. Finally, based on the proposed connection interval determination, we propose a priority inversion awareness scheduler for the BLE master node to schedule all slave node transmissions in the network. Extensive experiments show that the proposed algorithms prolonged network lifetime by 235% compared with a simple pessimistic setting.
Dynamic content attacks on digital signatures (2005)

Purpose Aims to address some of the problems that arise when signing digital documents that contain dynamic content. Design/methodology/approach Briefly introduces the problem of signing digital documents with dynamic content and discusses possible locations for signature functionality in a computer system. Outlines existing solutions to the problems and introduces a novel solution. Finally, discusses issues and unresolved problems. Findings The suggested solution requires all document handling applications to possess application awareness of the digital signature program in order to function properly. Every application must implement a COM interface and register itself in the Registry, in a locale specific to the digital signature program to sign the digital document. Originality/value Provides a new solution to the problem of digitally signing a digital document.
Planning-based configuration and management of distributed systems (2009)

The configuration and runtime management of distributed systems is often complex due to the presence of a large number of configuration options and dependencies between interacting sub-systems. Inexperienced users usually choose default configurations because they are not aware of the possible configurations and/or their effect on the systems' operation. In doing so, they are unable to take advantage of the potentially wide range of system capabilities. Furthermore, managing inter-dependent sub-systems frequently involves performing a set of actions to get the overall system to the desired final state. In this paper, we propose a new approach for configuring and managing distributed systems based on AI planning. We use a goal-driven, tag-based user interaction paradigm to shield users from the complexities of configuring and managing systems. The key idea behind our approach is to package different configuration options and system management actions into reusable modules that can be automatically composed into workflows based on the user's goals. It also allows capturing the inter-dependencies between different configuration options, management actions and system states. We evaluate our approach in a case study involving three inter-dependent sub-systems. Our initial experiences indicate that this planning-based approach holds great promise in simplifying configuration and management tasks.
The FLOWLENS: A Focus-and-Context Visualization Approach for Exploration of Blood Flow in Cerebral Aneurysms (2011)

Blood flow and derived data are essential to investigate the initiation and progression of cerebral aneurysms as well as their risk of rupture. An effective visual exploration of several hemodynamic attributes like the wall shear stress (WSS) and the inflow jet is necessary to understand the hemodynamics. Moreover, the correlation between focus-and-context attributes is of particular interest. An expressive visualization of these attributes and anatomic information requires appropriate visualization techniques to minimize visual clutter and occlusions. We present the FLOWLENS as a focus-and-context approach that addresses these requirements. We group relevant hemodynamic attributes to pairs of focus-and-context attributes and assign them to different anatomic scopes. For each scope, we propose several FLOWLENS visualization templates to provide a flexible visual filtering of the involved hemodynamic pairs. A template consists of the visualization of the focus attribute and the additional depiction of the context attribute inside the lens. Furthermore, the FLOWLENS supports local probing and the exploration of attribute changes over time. The FLOWLENS minimizes visual cluttering, occlusions, and provides a flexible exploration of a region of interest. We have applied our approach to seven representative datasets, including steady and unsteady flow data from CFD simulations and 4D PC-MRI measurements. Informal user interviews with three domain experts confirm the usefulness of our approach.
The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation (2010)

There is growing evidence that porcine reproductive and respiratory syndrome virus (PRRSV) has developed mechanisms to subvert the host innate immune response. PRRSV non-structural protein 2 (Nsp2) was suggested previously as a potential interferon (IFN) antagonist. This study focused on Nsp2 to investigate its inhibitory mechanism of IFN induction. It was demonstrated that Nsp2 strongly inhibited IFN-β production by antagonizing activation of the IFN regulatory factor 3 (IRF-3) pathway induced by the Sendai virus (SeV). Further studies revealed that the cysteine protease domain (PL2) of Nsp2 was necessary for IFN antagonism. Additionally, both full-length Nsp2 and the PL2 protease domain of Nsp2 were found to inhibit SeV-induced phosphorylation and nuclear translocation of IRF-3. These findings suggest that Nsp2 is likely to play an important role in subversion of IRF-3-dependent innate antiviral defences, providing a basis for elucidating the mechanisms underlying PRRSV pathogenesis.
FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival* (2005)

The adhesion molecules, P-selectin, ICAM-1, and VCAM-1 are important mediators of T-cell adhesion and T-cell co-stimulation. We investigated the effect of the malononitrilamide FK778 on cardiac allograft survival, acute allograft rejection, and adhesion molecule up-regulation in a heterotopic, cardiac transplantation model. Rats received low- or high-dose FK778 or no treatment. Grafts were harvested on the fifth postoperative day for histologic examinations. To assess allograft survival, recipients were treated for a maximum of 10 days and grafts were harvested after cessation of the contractile activity. FK778 low dose showed a mild but significant decrease in mononuclear infiltration but failed to markedly reduce histologic rejection, adhesion molecule up-regulation, or to prolong allograft survival. However, high-dose FK778 treatment significantly reduced early up-regulation of P-selectin, ICAM-1, and VCAM-1, abolished infiltration, reduced histologic rejection and resulted in prolonged cardiac allograft survival. Therefore, FK778 is a novel, highly desirable immunosuppressive drug for transplantation medicine.
PULSED MICROWAVE-VACUUM DRYING OF FOOD MATERIALS (1999)

ABSTRACT Microwave drying of food materials has been investigated over several years as a potential means for reducing the total drying time. However, some quality loss almost always accompanied when foods were dried completely using microwaves due to nonuniform temperature and moisture distribution. Some strategies used to improve dried product quality include combination of microwave and conventional hot air drying. pulsed or intermittent drying, and microwave-vacuum drying. Combination of pulsing and vacuum drying is a useful technique to maximize energy use efficiency and product quality especially for temperature sensitive products such as fruits. Some results of pulsed, microwave-vacuum drying of cranberries are presented. Pulsed drying is more energy efficient than continuous drying. In pulsed drying, the longer the pulsing ratio (i.e. longer power-off time in relation to power-on time) was more energy efficient. The quality of pulse-dried product was also generally better than that of continuous-dried product. The cycle power-on time and pulsing ratio should be carefully selected to obtain maximize the benefits of pulsed, microwave vacuum drying
Design of Automatic Fall Detector for Elderly Based on Triaxial Accelerometer (2009)

Falls in elderly people have been recognized as a major health problem in aging population. This paper describes the development of an accurate, accelerometer based fall detector capable of locating the wearer and sending alarm short messages (SMS). The device worn on the waist uses a two-stage fall detection algorithm, which senses rapid impact and body orientation of the wearer. To evaluate the device and the algorithm, an experiment on 5 subjects was conducted. The device is especially adapted to safely and accurately monitor elderly people without influencing their privacy and comfort. It is hoped that such a device will promote an integrated approach to the management of falls of elderly in the community.
IAB Considerations for UNilateral Self-Address Fixing (UNSAF) Across Network Address Translation (2002)

As a result of the nature of Network Address Translation (NAT) Middleboxes, communicating endpoints that are separated by one or more NATs do not know how to refer to themselves using addresses that are valid in the addressing realms of their (current and future) peers. Various proposals have been made for UNilateral Self-Address Fixing (UNSAF) processes. These are processes whereby some originating endpoint attempts to determine or fix the address (and port) by which it is known to another endpoint - e.g. to be able to use address data in the protocol exchange, or to advertise a public address from which it will receive connections.
Is <i>BRCA1</i>/<i>BRCA2</i>‐related breast carcinogenesis estrogen dependent? (2005)

Estrogen is a well known promoting factor of sporadic breast carcinoma. With regard to hereditary breast carcinoma, such as in BRCA1/BRCA2 syndromes, to date, the effects of estrogens on risk modification are not clear. Several studies have shown that prophylactic oophorectomy may decrease the risk of breast carcinoma in BRCA1/BRCA2 mutation carriers. Moreover, adjuvant tamoxifen therapy for primary breast carcinoma appears to diminish the risk of a second breast malignancy in BRCA1 mutation carriers. Conversely, exogenous estrogens, such as oral contraceptives, may increase the risk of breast carcinoma in familial breast cancer, as suggested by clinical studies. Paradoxically, the majority of BRCA1-related breast carcinomas are negative for ER. There is some biologic evidence of interactions between estrogens and BRCA proteins. BRCA1 expression could be induced by estradiol in experimental models, whereas recent studies indicate that BRCA1 modifies the regulatory effects of the estrogen receptor (ER) alpha (ERalpha). Prospective studies will be required to estimate the potential benefits of estrogen suppression therapies for the prevention and adjuvant treatment of BRCA1/BRCA2-related breast carcinomas.
Cura: A Cost-Optimized Model for MapReduce in a Cloud (2013)

We propose a new MapReduce cloud service model, Cura, for data analytics in the cloud. We argue that performing MapReduce analytics in existing cloud service models - either using a generic compute cloud or a dedicated MapReduce cloud - is inadequate and inefficient for production workloads. Existing services require users to select a number of complex cluster and job parameters while simultaneously forcing the cloud provider to use those potentially sub-optimal configurations resulting in poor resource utilization and higher cost. In contrast Cura leverages MapReduce profiling to automatically create the best cluster configuration for the jobs so as to obtain a global resource optimization from the provider perspective. Secondly, to better serve modern MapReduce workloads which constitute a large proportion of interactive real-time jobs, Cura uses a unique instant VM allocation technique that reduces response times by up to 65%. Thirdly, our system introduces deadline-awareness which, by delaying execution of certain jobs, allows the cloud provider to optimize its global resource allocation and reduce costs further. Cura also benefits from a number of additional performance enhancements including cost-aware resource provisioning, VMaware scheduling and online virtual machine reconfiguration. Our experimental results using Facebook-like workload traces show that along with response time improvements, our techniques lead to more than 80% reduction in the compute infrastructure cost of the cloud data center.
A Compact 3-D Printed Asymmetric Orthogonal Mode Transducer (2020)

In this article, a compact 3-D-printed orthogonal-mode transducer (OMT) is proposed. Unlike conventional OMT that uses long extended transition for port matching, the proposed design uses embedded fences and novel short tapered triangular prism (TTP) to replace such long transition. In this way, the size of the OMT can be reduced. The TTP effectively improves the matching of the perpendicularly transverse port without affecting the performance of the port aligned with the common port. The fence acts as a polarizer grid to further reduce the reflection of incident waves back into the input port. The return loss and isolation of the very compact OMT are better than 16 and 40 dB, respectively, from 2.65 to 3.2 GHz. Considering the complicated geometry of the proposed OMT, 3-D metal printing technology is adopted as the fabrication method. The measurement results agree well with the simulation results.
The effects of dynamic updating of tactical information on situation awareness and performance in an attack helicopter domain (2002)

As part of a research program investigating tactical situation awareness (SA) in attack helicopter missions, we investigated alternative methods for displaying dynamically changing tactical information to maintain high levels of SA and task performance. We conducted two experiments in which we investigated display features that could improve SA and performance, including automatic updating of enemy and friendly unit locations, and availability of unit history information. Subjects reported higher awareness of tactical changes with periodic updates than continual real-time updates, but the periodic updates did not help the crew ascertain which units had moved since the previous update, a very important aspect of maintaining awareness of enemy and friendly status and determining enemy intent. We also compared textual and graphical methods for displaying traces of unit movements, but found no differences in SA or performance between the two methods. The research raised a number of cognitive issues associated with dynamic updating of tactical information and the display of unit histories.
Study on the Development of Environmental Industry in China (2014)

Environmental industry has become one of the world's hottest sunrise industry and there is a big necessity for China to import leading environmental technology from the EU to develop environmental industry and build Sustainable economic development.However,problems such as unsatisfying environmental policy implementation,not advanced environmental technology R&D investment and financing system,lacking of long-term strategic planning and not perfect innovation mechanism and talent management and so on,greatly reduce the efficiency of putting the technology introduced into use and developing the environmental industry.In order to solve that,government have to strengthen the environmental supervision,formulate appropriate R&D investment and financing policy,enact enterprise long-term strategic planning and also improve the personnel management.