gebhart/patrepeval huggingface dataset:
Sensing of Particulate Matter for On-Board Diagnosis of Particulate Filters (2012)

<div class="section abstract"><div class="htmlview paragraph">New particulate sensing technologies are currently being readied for production to meet the on-board diagnostic (OBD) regulations associated with diagnosing diesel particulate filter (DPF) efficiency. The threshold levels for diagnosis have been tightened starting in 2013, requiring a new approach beyond the current techniques which often rely on differential pressure sensing across the filter. A new sensor has been developed to directly detect the particles passing through the DPF and estimate the cumulative particle flow. Using this information, an estimate can be made of the filter's efficiency and an associated diagnosis of its ability to meet emissions requirements. In this paper we will discuss the sensor's operating principle, accuracy and repeatability. Experimentally-observed variability of exhaust particulate matter will be compared to simulated deposition of soot<sup>1</sup> in a modeling environment.</div><div class="htmlview paragraph"><sup>1</sup>The authors acknowledge that “soot” is an imprecise colloquial term relating to chimney deposits. Soot is used for brevity in this paper and is intended to be interchangeable, unless otherwise noted, with “particulate matter,” since the sensor in discussion has the potential to collect the full range of particulate matter in the exhaust, as opposed to only a purely carbonaceous fraction [<span class="xref">4</span>].</div></div>
Intelligent Matching of the Control Voltage of Delay Line Interferometers for Differential Phase Shift Keying-Modulated Optical Signals (2021)

In optical communications, differential phase shift keying (DPSK) provides a desired modulation format that offers high tolerance to nonlinear effects in high-speed transmissions. A DPSK demodulator converts the phase-coded signal into an intensity-coded signal at receivers. One demodulation scheme is called balanced detection and is based on a tunable delay line interferometer (DLI). Demodulation performances are determined by the phase delay generated by the DLI, while the phase delay is controlled by a tunable driving voltage on the DLI device. However, a problem in the dynamic adjustment of the control voltage prevents the application of DPSK demodulators. The receivers need to scan the whole control voltage range of the DLI and find the control voltage that maximizes the demodulation performance, but the scan-based method needs to undergo a very long searching time. In our work, we found that the relation between DLI control voltages and demodulation performance can be predicted rapidly by a feedforward neural network (FNN). In this paper, we propose a new method to quickly locate the best DLI control voltage based on an FNN. We also verify the proposed method in simulations and telecommunication systems, and the results show that the proposed method can significantly improve the efficiency of resolving the best demodulation voltages.
Selective dopamine D<sub>3</sub> receptor antagonism by SB‐277011A attenuates cocaine reinforcement as assessed by progressive‐ratio and variable‐cost–variable‐payoff fixed‐ratio cocaine self‐administration in rats (2005)

In rats, acute administration of SB-277011A, a highly selective dopamine (DA) D(3) receptor antagonist, blocks cocaine-enhanced brain stimulation reward, cocaine-seeking behaviour and reinstatement of cocaine-seeking behaviour. Here, we investigated whether SB-277011A attenuates cocaine reinforcement as assessed by cocaine self-administration under variable-cost-variable-payoff fixed-ratio (FR) and progressive-ratio (PR) reinforcement schedules. Acute i.p. administration of SB-277011A (3-24 mg/kg) did not significantly alter cocaine (0.75 mg/kg/infusion) self-administration reinforced under FR1 (one lever press for one cocaine infusion) conditions. However, acute administration of SB-277011A (24 mg/kg, i.p.) progressively attenuated cocaine self-administration when: (a) the unit dose of self-administered cocaine was lowered from 0.75 to 0.125-0.5 mg/kg, and (b) the work demand for cocaine reinforcement was increased from FR1 to FR10. Under PR (increasing number of lever presses for each successive cocaine infusion) cocaine reinforcement, acute administration of SB-277011A (6-24 mg/kg i.p.) lowered the PR break point for cocaine self-administration in a dose-dependent manner. The reduction in the cocaine (0.25-1.0 mg/kg) dose-response break-point curve produced by 24 mg/kg SB-277011A is consistent with a reduction in cocaine's reinforcing efficacy. When substituted for cocaine, SB-277011A alone did not sustain self-administration behaviour. In contrast with the mixed DA D(2)/D(3) receptor antagonist haloperidol (1 mg/kg), SB-277011A (3, 12 or 24 mg/kg) failed to impede locomotor activity, failed to impair rearing behaviour, failed to produce catalepsy and failed to impair rotarod performance. These results show that SB-277011A significantly inhibits acute cocaine-induced reinforcement except at high cocaine doses and low work requirement for cocaine. If these results extrapolate to humans, SB-277011A or similar selective DA D(3) receptor antagonists may be useful in the treatment of cocaine addiction.
Gastrointestinal Microflora in Mammalian Nutrition (1986)

A mammal is a complex organism consisting of eukaryotic animal cells and eukaryotic and prokaryotic microbial cells. Most of the microorganisms reside in communities in the gastrointestinal tract. These gastrointestinal microfloras are known to serve nutritional functions in ruminants, pseudoruminants, and monogastric mammals with only modest or no foregut fermentations but with extensive hindgut fermentations in blind cecal pouches. In adult animals, the microflora hydrolyzes exogenous (dietary) and endogenous polymers, and provides the adult with all or at least a significant proportion of its carbon, energy, vitamins, and macromolecular building blocks. The flora also functions as a conservator of nitrogen that would otherwise be excreted as urea. In exchange, the flora competes directly with the host tissues for nutrients ingested in the diet, and also competes indirectly by somewhat repressing the absorptive capacities of the animal tissues. When the synergism is in balance, the animal tissues and the microflora operate in harmony for the health and nutritional welfare of the host as a whole. The system may be unbalanced by antibacterial drugs that destroy the microflora and by diseases of the animal tissues that destroy the controls regulating where indigenous communities localize in the tract, their microbial composition, and their biochemical activities. At such times, the nutrition of the animal tissues can be adversely affected to the extreme. Humans living in developed and developing countries have extensive microfloras in their hindguts. Humans living in developing countries may also have extensive microfloras in their small bowels. Those floras may function in nutrition of the animal tissues of man much the same as do floras in similar locations in the gastrointestinal tracts of mammals other than man. However, animals of some species other than human gain much of the nutritional benefit from their microflora through the practice of coprophagy. Since adult humans do not normally practice coprophagy, any nutritional benefit from the microflora depends upon the capacity of the bowel mucosa, principally that of the large bowel, to absorb bacterial products, e.g. short-chain volatile fatty acids. Such absorption undoubtedly occurs, but is surely not a major source of carbon and energy for the animal tissues of man.
Safety and efficacy of capecitabine (C) plus bevacizumab (B) as first-line in metastatic breast cancer (2007)

1013 Background: C alone has good activity and tolerability in metastatic breast cancer (MBC) and when combined with docetaxel improves response and survival. C combined with B in heavily pretreated MBC improved the response rate but not PFS. In untreated MBC, the addition of B to chemotherapy significantly improves progression-free survival (PFS) which suggests that B, is most effective in early disease. Methods: Primary objective of this single-arm, 2-phase study, is to evaluate PFS in MBC patients receiving first-line treatment with C 1,000 mg/m 2 twice daily on days 1–15 (28 doses) and B 15 mg/kg on day 1. Treatment was repeated every 21 days until progression. Eligibility criteria included HER2-negative MBC previously untreated for metastatic disease; ECOG performance status =1; no prior anti-angiogenic or oral fluoropyrimidine therapy. A sample size of 109 patients (including dropouts) was required to give 90% power to test an improvement from 4 months median PFS to 5.6 months with the two-sided test (a 5%) Results: At data cut-off, 103 patients had received study medication. Present results are based on 103 patients (ITT population), except tumor response which is based on 91 patients who had response evaluation. The average # of cycles received in first phase is 6.8. 84 pts.are alive at this time. 38.5% (35/91) pts. have had a response: complete response 5.5%; partial response 33.0%. Stable disease is 42.9% with 81.4% clinical benefit. Planned dose received is 77.7 % for C and 99.0 % for B. The majority of adverse events (AEs) were mild or moderate. The most common grade 3 AEs were hand-foot syndrome (13%) and pain (10%); grade 4 pulmonary embolism occurred in 2% in the first phase of the study. Conclusions: Updated results with longer follow-up including toxicity, TTP and PFS will be presented at the meeting. It appears that in first-line C+B is active for MBC and is well tolerated, with few grade 3/4 toxicities. [Table: see text]
Intraventricular Infusions of Anti‐Neural Cell Adhesion Molecules in a Discrete Posttraining Period Impair Consolidation of a Passive Avoidance Response in the Rat (1992)

Intraventricular infusions of anti-neural cell adhesion molecule (anti-NCAM) are demonstrated to inhibit consolidation of a passive avoidance response when administered in the 6-8 h posttraining period. Anti-NCAM was ineffective when administered during training or at any other time up to 10 h thereafter, and no amnesic effects were observed with absorbed anti-NCAM or anti-neurofilament protein. Amnesia was observed only at the 48-h recall time, and this could not be attributed to poor antibody penetration or a prolonged residence time, as studies with 125I-labelled anti-NCAM in trained animals demonstrated a rapid accumulation into all brain regions, and this was marked in the olfactory bulb and hippocampus, areas showing an inherent and paradigm-specific increase in NCAM sialylation state, respectively. The lack of an amnesic action at the 24-h recall time is attributed to anti-NCAM-impaired synapse structuring becoming apparent following the paradigm-specific increases in NCAM sialylation state.
Dynamic Changes in the Initial Colonization of Actinomyces naeslundii and Streptococcus gordonii Using a New Animal Model (2013)

Actinomyces naeslundii and Streptococcus gordonii are the predominant bacteria and initial colonizers of oral microflora. The binding of A. naeslundii and S. gordonii and the interaction between them on the salivary pellicle-coated tooth surface play an important role in the biofilm development. Recently, we reported that NOD/SCID.e2f1(-) mice are a useful model for studying oral biofilm formation by Streptococcus mutans on the tooth surface. In this study, we aimed to determine whether NOD/SCID.e2f1(-) mice can be used for studying oral colonization of A. naeslundii and S. gordonii. Colonization of A. naeslundii in mice fed with 1% sucrose water for 24 h before inoculation was higher than that among mice fed with sucrose water for 1 h. A. naeslundii colonization using mixed species-inoculation was lower than that using single-species inoculation 30-90 min after inoculation; however, the colonization was higher 120-180 min after inoculation. The mixed inoculation induced better colonization of S. gordonii than single-species inoculation 60-180 min after inoculation. Polyclonal and fluorescein isothiocyanate-labeled antibody stained bacteria showed better colonization of S. gordonii when a mixed culture is used in vivo. NOD/SCID.e2f1(-) mice were useful for studying the initial colonization of A. naeslundii and S. gordonii. Long-term supply of sucrose water creates a favorable environment for the initial colonization of A. naeslundii that, in turn, supports the colonization of S. gordonii.
Photometric Consistency For Dual Fisheye Cameras (2020)

Back-to-back dual fisheye cameras are the most popular and cost-effective device to capture 360° images. However, inconsistent intensity and color between the pair of fisheye images often cause visible artifacts in the final 360° image. In this paper, we present a method to create photometric consistency between the two fisheye images. Specifically, we propose a loss function for image intensity compensation and a local color transfer model for color correction. Experimental results show that our method is able to correct the photometric inconsistency between dual fisheye images for high-quality 360° imaging.
Three jailed in Germany for selling a fraudulent cancer cure to terminally ill patients (2008)

A court in the central German town Kassel has sentenced three men to jail for fraud because in 2000-1 they sold and administered a food supplement, which they claimed was a cure for cancer, to more than 150 terminally ill cancer patients. All the patients subsequently died. The verdict was given this week after a 16 month trial.

A doctor, a businessman, and a journalist had persuaded dying people that a Russian food supplement, Galavit, was able to stop their cancer. Patients had to pay about €8500 (£6800; $13 500) for the treatment course, which …
Impact of Electrical Contact Resistance on the High-Speed Transmission and On-Line Diagnosis of Electrical Connector Intermittent Faults (2017)

Electrical connectors are widely used in many kinds of main equipment. It is very difficult, costly, and time consuming for the off-line diagnosis of intermittent faults (IFs) in connectors. To realize the on-line diagnosis by the traditional method, the voltage drop between two ends of the connector should be measured continuously at a high sample rate. This continuous measurement requires enormous testing resources, which is impractical in engineering fields. To solve this problem, this paper proposes an on-line diagnosis method in condition of the single-end test for the electrical connector IFs. To determine the fault threshold of the electrical contact resistance (ECR), first the impact of the ECR on high-speed transmission is studied, and then the connector fault feature in condition of the single-end test, which is called the insertion loss increment (ILI), is extracted. The measurement method of the ILI is also presented. Based on the above analysis, an ILI-based on-line diagnosis method for the connector IFs is specified. According to the qualitative and quantitative tests, the proposed diagnosis method is verified. The verification results show that the cumulative insertion loss increment, which is calculated from the ILI can truly exhibit the variation of ECR, and the error of the ILI-based diagnosis method is only about 1%.
Renal effects of a neutralising RAGE-antibody in long-term streptozotocin-diabetic mice (2006)

Advanced glycation endproducts (AGEs) have been implicated in the pathogenesis of diabetic kidney disease. The actions of AGEs are mediated both through a non-receptor mediated pathway and through specific receptors for AGEs (e.g. RAGE). To explore a potentially specific role for RAGE in renal changes in type 1 diabetes, we examined the renal effects of a neutralising murine RAGE-antibody (ab) in streptozotocin (STZ)-diabetic mice, a model of type 1 diabetes. One group of STZ-diabetic mice was treated for two months with the RAGE-ab, while another STZ-diabetic group was treated for the same period with an irrelevant immunoglobulin G (IgG). Two groups of non-diabetic NMRI mice were treated with either RAGE-ab or isotype-matched IgG for two months. Placebo-treated STZ-diabetic mice showed an increase in kidney weight, glomerular volume, basement membrane thickness (BMT), urinary albumin excretion (UAE) and creatinine clearance (CrCl), when compared with non-diabetic controls. In RAGE-ab-treated STZ-diabetic mice, the increase in kidney weight and UAE was reduced, while the increase in CrCl was abolished. RAGE-ab administration in NMRI mice caused a reduction in liver weight and an increase in BMT. Renal messenger RNA (mRNA) for connective tissue growth factor and collagen IValpha1 was increased in placebo-treated diabetic animals. RAGE-ab treatment had no impact on the expression of these factors. The renal effects of RAGE-ab administration in STZ-diabetic mice were seen without impact on body weight, blood glucose or food consumption. In conclusion, the present data support the hypothesis that RAGE is an important pathogenic factor in the renal changes in an animal model of type 1 diabetes.
Effect of Potassium Citrate on Bone Density, Microarchitecture, and Fracture Risk in Healthy Older Adults without Osteoporosis: A Randomized Controlled Trial (2012)

Among a group of healthy elderly persons without osteoporosis, treatment with K-citrate for 24 months resulted in a significant increase in aBMD and volumetric BMD at several sites tested, while also improving bone microarchitecture. Based on the effect on fracture prediction, an effect on future fractures by K-citrate is possible.
Auroral all-sky camera calibration (2014)

Abstract. A two-step procedure to calibrate the spectral sensitivity to visible light of auroral all-sky cameras is outlined. Center pixel response is obtained by the use of a Lambertian surface and a standard 45W tungsten lamp. Screen brightness is regulated by the distance between the lamp and the screen. All-sky flat-field correction is carried out with a 1 m diameter integrating sphere. A transparent Lexan dome at the exit port of the sphere is used to simulate observing conditions at the Kjell Henriksen Observatory (KHO). A certified portable low brightness source from Keo Scientific Ltd. was used to test the procedure. Transfer lamp certificates in units of Rayleigh per Ångstrøm (R Å−1) are found to be within a relative error of 2%. An all-sky camera flat-field correction method is presented with only 6 required coefficients per channel.
YAP: At the crossroad between transformation and tumor suppression (2009)

Yap is a small protein that binds to many transcription factors and modulates their activity. Yap was described to increase the ability of p73 in inducing apoptosis as a consequence of damage to the DNA, and therefore its activity was thought to favor tumor-suppression. However, other studies have recently shown a role for Yap in cell differentiation, cell transformation and in the regulation of organ size. It has been demonstrated that the Drosophila Hippo pathway has a mammalian equivalent, and that Yap is part of this pathway, where it might stimulate proliferation. In light of these new findings we ought to re-consider the role of Yap, which seems to be in service of several masters, and whose regulation--likely at the level of PTM--and cellular context might have a pivotal role in the choice of its partners and consequently on the final outcome.
Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats (2001)

Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone that is released postprandially from the small intestine and acts in concert with glucagon-like peptide (GLP)-1 to potentiate glucose-induced insulin secretion from the pancreatic beta-cell. In type 2 diabetes, there is a decreased responsiveness of the pancreas to GIP; however, the insulin response to GLP-1 remains intact. The literature suggests that the ineffectiveness of GIP in type 2 diabetes may be a result of chronic homologous desensitization of the GIP receptor. Yet, there has been no conclusive evidence suggesting that GIP levels are elevated in diabetes. The hypothesis of the present study is that one cause of decreased responsiveness to GIP in type 2 diabetes is an inappropriate expression of the GIP receptor in the pancreatic islet. This hypothesis was tested using a strain of diabetic fatty Zucker rats. The obese rats displayed basal GIP levels similar to the control animals; however, they were unresponsive to a GIP infusion (4 pmol.min(-1). kg(-1)), whereas the lean animals displayed a significant reduction in blood glucose (GIP levels, 50% control after 60 min, P < 0.05) as well as a significant increase in circulating insulin. GIP also potently stimulated first-phase insulin secretion from isolated perifused islets (10.3 +/- 3.0 x basal), and GIP and GLP-1 potentiated insulin secretion from the perfused pancreas (6 x control area under the curve [AUC]) from lean animals. GIP yielded no significant effect in the Vancouver diabetic fatty Zucker (VDF) rat pancreases, whereas GLP-1 elicited an eightfold increase of insulin secretion from the perfused VDF pancreas. Islets from lean animals subjected to static incubations with GIP showed a 2.2-fold increase in cAMP, whereas GIP failed to increase islet cAMP in the VDF islets. Finally, the expression of both GIP receptor mRNA and protein was decreased in islets from VDF rats. These data suggest that the decreased effectiveness of GIP in the VDF rat and in type 2 diabetes may be a result of a decreased receptor expression in the islet.
An Internally Heated, Rapid-quench, High-pressure Vessel (1992)

A pressure vessel and furnace system were desigrred for rapid-quench operation while maintaining the advantages of sample size and hydrostatic loading inherent in an internally heated, Ar-medium vessel (IHPV). The rapid quench is achieved using the quench-wire technique common to atmospheric pressure quench furnaces; the sample capsules fall from their position in the furnace hot spot into room-temperature Ar gas at the bottom of the vessel chamber. The quench rate is several hundred degrees Celsius per second compared to a rate of about 3 °C/s in conventional IHPVs. The system operates at temperatures up to at least 1300 °C and pressures up to 1500 bars, conditions specifically chosen to study solubilities of H2O, CO2, and other volatiles in low-viscosity silicate melts that have shown severe quench effects in IHPVs having normal quench rates. Loading and unloading the pressure system is relatively simple and fast.
Clinical Spectrum of Leishmaniasis (1996)

The clinical manifestations of leishmaniasis depend on com­ plex interactions between the virulence characteristics of the infecting Leishmania species and the immune responses of its host. The result is a spectrum of disease ranging from localized skin lesions to diffuse involvement of the reticuloendothelial system. Human disease has traditionally been divided into three major clinical syndromes: visceral, cutaneous, and mucosal leishmaniasis; however, a number of variants exist. Further­ more, a single Leishmania species can produce more than one clinical syndrome, and each syndrome is caused by multiple species. The true incidence and prevalence of leishmaniasis is uncer­ tain because many cases go undiagnosed or unreported in areas where the infection is endemic. In 1993, the World Health Organization estimated that 350 million people worldwide were at risk for infection. The incidence of cutaneous leishmaniasis has been estimated to be 1.0-1.5 million cases per year, and