gebhart/patrepeval huggingface dataset:
Dermal application of JP-8 jet fuel induces immune suppression (1999)

Chronic exposure to JP-8 jet fuel induces lung toxicity, adverse neurological effects and some liver and kidney dysfunction. In addition, inhalation of JP-8 induces immune suppression. Besides the lung, the other major route of JP-8 exposure is via the skin. In this study we tested the hypothesis that dermal exposure to JP-8 is immune suppressive. JP-8 was applied to the skin of adult female C3H/HeN mice and various immune parameters were examined. Dermal exposure to JP-8, either multiple small exposures (50 microl for 5 days) or a single large dose (250-300 microl) resulted in immune suppression. The induction of contact hypersensitivity was impaired in a dose-dependent manner regardless of whether the contact allergen was applied directly to the JP-8-treated skin or at a distant un-treated site. In addition, the generation of a classic delayed-type hypersensitivity reaction to a bacterial antigen (Borellia burgdorferi) injected into the subcutaneous space was suppressed by dermal application of JP-8 at a distant site. The ability of splenic T lymphocytes from JP-8-treated mice to proliferate in response to plate-bound monoclonal anti-CD3 was also significantly suppressed. Interleukin-10, a cytokine with potent immune suppressive activity, was found in the serum of JP-8-treated mice, suggesting that the mechanism of systemic immune suppression may involve the upregulation of cytokine release by JP-8. These findings confirm the immunosuppressive effects of JP-8 and demonstrate that dermal exposure to JP-8 is immunotoxic.
Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation (2017)

Synthetic diblock copolypeptides were designed to incorporate oppositely charged ionic segments that form β-sheet-structured hydrogel assemblies via polyion complexation when mixed in aqueous media. The observed chain conformation directed assembly was found to be required for efficient hydrogel formation and provided distinct and useful properties to these hydrogels, including self-healing after deformation, microporous architecture, and stability against dilution in aqueous media. While many promising self-assembled materials have been prepared using disordered or liquid coacervate polyion complex (PIC) assemblies, the use of ordered chain conformations in PIC assemblies to direct formation of new supramolecular morphologies is unprecedented. The promising attributes and unique features of the β-sheet-structured PIC hydrogels described here highlight the potential of harnessing conformational order derived from PIC assembly to create new supramolecular materials.
Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of<i>bcl</i>-2 promoter activity (1997)

c-Myb, the cellular homologue of the transforming gene of the avian myeloblastosis virus, is preferentially expressed in all hematopoietic lineages, including T and B lymphocyte lineages. In T lymphocytes, c-Myb expression appears to be required for cell cycle progression and proliferation. To further investigate the role of c-Myb in T cell proliferation and survival, interleukin (IL) 2-dependent CTLL-2 cells were transfected with a constitutively active c-myb or with a c-myb antisense construct able to down-regulate endogenous Myb levels, and the transfectants were assessed for proliferation and survival in low concentrations of IL-2 and for susceptibility to dexamethasone-induced apoptosis. Compared with control cells, CTLL-2 cells constitutively expressing c-Myb proliferate in low concentrations of IL-2 and are less susceptible to apoptosis induced by IL-2 deprivation or treatment with dexamethasone. In contrast, cells transfected with an antisense c-myb construct do not proliferate in low concentrations of IL-2 and undergo apoptosis upon IL-2 deprivation or dexamethasone treatment more rapidly than parental cells. Overexpression of c-Myb was accompanied by up-regulation of BCL-2 expression. In transient transfection assays, the murine bcl-2 promoter was efficiently transactivated by c-Myb, but such effect was observed also in cells transfected with a DNA binding-deficient c-myb construct. Moreover, in gel retardation assays, a 38-bp oligomer in the shortest bcl-2 promoter segment regulated by c-Myb formed a specific complex with nuclear extracts from c-Myb-transfected CTLL-2 cells. Thus, these results strongly suggest that c-Myb, in addition to regulating T cell proliferation, protects T lymphocytes from apoptosis by induction of BCL-2 expression, which involves a c-Myb-dependent mechanism of promoter regulation.
Fetal DNA in maternal plasma as a screening variable for preeclampsia. A preliminary nonparametric analysis of detection rate in low‐risk nonsymptomatic patients (2004)

The estimated DR allows to consider fetal DNA as a potential variable to predict preeclampsia in a low-risk population. Further studies will be addressed to calculate a parametric statistical algorithm and to estimate a proper posterior risk of the disease by means of fetal DNA alone or combined with other markers.
FastCap: An efficient and fair algorithm for power capping in many-core systems (2016)

Future servers will incorporate many active low-power modes for different system components, such as cores and memory. Though these modes provide flexibility for power management via Dynamic Voltage and Frequency Scaling (DVFS), they must be operated in a coordinated manner. Such coordinated control creates a combinatorial space of possible power mode configurations. Given the rapid growth of the number of cores, it is becoming increasingly challenging to quickly select the configuration that maximizes the performance under a given power budget. Prior power capping techniques do not scale well to large numbers of cores, and none of those works has considered memory DVFS. In this paper, we present FastCap, our optimization approach for system-wide power capping, using both CPU and memory DVFS. Based on a queuing model, FastCap formulates power capping as a non-linear optimization problem where we seek to maximize the system performance under a power budget, while promoting fairness across applications. Our FastCap algorithm solves the optimization online and efficiently (low complexity on the number of cores), using a small set of performance counters as input. To evaluate FastCap, we simulate it for a many-core server running different types of workloads. Our results show that FastCap caps power draw accurately, while producing better application performance and fairness than many existing CPU power capping methods (even after they are extended to use of memory DVFS as well).
Molecular Shuttles by the Protecting Group Approach (2000)

Two new [2]rotaxane-based molecular shuttles, in which a mechanically bound dibenzo[24]crown-8 (DB24C8) macroring shunts back and forth between two dialkylammonium recognition sites situated on a chemical dumbbell, have been constructed by a novel synthetic strategy that relies upon the use of the tert-butoxycarbonyl (Boc) protecting group. During the syntheses of both molecular shuttles, this protecting group masks a dialkylammonium recognition center which is liberated only after the [2]rotaxane constitution is established. In both cases, the molecular shuttles' other dialkylammonium center is essential for the rotaxane-forming reactions and it ensures that DB24C8 is interpenetrated by threadlike precursors, as a result of noncovalent bonding interactions, to produce [2]pseudorotaxanes which are stoppered subsequently through 1,3-dipolar cycloadditions between azides and bulky acetylenedicarboxylates. The new molecular shuttles have been examined by means of dynamic 1H NMR spectroscopy, which reveals that the movements of the DB24C8 macroring are very highly dependent both on solvent properties and on the nature of the spacer unit linking the two dialkylammonium centers. Thus, DB24C8 shunts facilely between the dialkylammonium centers when the shuttles are dissolved in solvents that readily donate their nonbonding electrons into noncovalent bonds, e.g., DMF, and when spacer units that do not offer much steric resistance to shuttling, e.g., hexamethylene, are used. On the other hand, shuttling is difficult in solvents that are less inclined to donate their electrons into noncovalent bonds, e.g., (CDCl2)2, and when relatively bulky benzenoid spacer units, e.g., p-xylylene, link the two dialkylammonium centers. It has been proposed that the DB24C8 might act as a "ferry" which carries a proton between dialkylammonium and dialkylamine moieties in a singly protonated [2]rotaxane by means of ion-dipole interactions.
Lipid Adsorption onto Hydrogel Contact Lens Materials. Advantages of Nile Red over Oil Red O in Visualization of Lipids (1991)

An artificial tear solution containing the major types of proteins, glycoproteins, and lipids represented in human tears has been developed. The adsorption of lipids onto various hydrogel lens materials (polymacon, lidofilcon A, phemfilcon A, etafilcon A) was examined by exposing the lenses to our artificial tear solution for 18 h. The adsorbed lipids were detected using Nile red stain. The patterns of deposits obtained in vitro were similar to those obtained with human worn lenses. The Nile red stain appeared far more sensitive in detecting lipids adsorbed to hydrogel lenses than the oil red O stain. It was found that lipids adsorb to hydrogel materials quite readily either in a pure state or combined with mucin or other proteins. In view of this work more attention should be given to the role of lipids in the etiology of various contact lens wear complications.
Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway (2010)

The chlamydial protease/proteasome-like activity factor (CPAF) is secreted into the host cytosol to degrade various host factors that benefit chlamydial intracellular survival. Although the full-length CPAF is predicted to contain a putative signal peptide at its N terminus, the secretion pathway of CPAF is still unknown. Here, we have provided experimental evidence that the N-terminal sequence covering the M1-G31 region was cleaved from CPAF during chlamydial infection. The CPAF N-terminal sequence, when expressed in a phoA gene fusion construct, was able to direct the export of the mature PhoA protein across the inner membrane of wild-type Escherichia coli. However, E. coli mutants deficient in SecB failed to support the CPAF signal-peptide-directed secretion of PhoA. Since native PhoA secretion was known to be independent of SecB, this SecB dependence must be rendered by the CPAF leader peptide. Furthermore, lack of SecY function also blocked the CPAF signal-peptide-directed secretion of PhoA. Most importantly, CPAF secretion into the host cell cytosol during chlamydial infection was selectively inhibited by an inhibitor specifically targeting type I signal peptidase but not by a type III secretion-system-specific inhibitor. Together, these observations have demonstrated that the chlamydial virulence factor CPAF relies on Sec-dependent transport for crossing the chlamydial inner membrane, which has provided essential information for further delineating the pathways of CPAF action and understanding chlamydial pathogenic mechanisms.
A polarization-reconfigurable filtering antenna system: a visual approach to investigating the bandwidth of transmission lines with non-z0 impedance [education column] (2013)

The Education Column publishes project reports from f nalists in the AP-S Student Design Challenge. In this issue, we present the report from the 2013 team from the School of Electrical and Electronics Engineering at Nanyang Technological University, Singapore: Theng Huat Gan, Zaifeng Yang, Eng Leong Tan, Jun Xian Lim, Minh Quan Huynh, and Moody Mayank. The challenge was to develop a system with reconf gurable antenna elements that could adapt to different propagation conditions to achieve the best link performance.
Does topical minoxidil increase skin blood flow? A laser Doppler flowmetry study. (1988)

Cutaneous blood flow was measured by Laser Doppler Flowmetry after topical application of minoxidil lotion, in 9 healthy males with androgenetic alopecia, and other volunteers. No reaction in the cutaneous blood flow was seen after application of 2%, 5%, or placebo minoxidil lotion.
Studies in Red Blood Cell Preservation 1. Effect of the Other Formed Elements (1990)

The purpose of this study was to determine if the removal of most of the leukocytes and platelets would affect the in vitro characteristics of stored red blood cells (RBC). Fresh RBC concentrates prepared by removing platelet-rich plasma and filtration through Imugard IG 500 filters were compared with unmanipulated units after storage for up to 56 days. The filtered units were significantly better after 56 days storage for supernatant K+ (p = 0.001), hemolysis (p = 0.05), total vesicle membrane protein shed (p = 0.03), and RBC morphology score (p = 0.04). These differences occurred even though ATP levels were well maintained in both groups. The measurements that did not differ significantly were pH, hematocrit, ATP, 2,3-DPG, glucose and supernatant Na+. It is suggested that enzymes, leukotrienes, catecholamines and eicosanoids released by degenerating leukocytes and platelets may be inimical to RBC. Some may act as agonists on alpha-adrenergic and cholinergic muscarinic receptors present on RBC membranes.
Effects of a Complex Mixture of Therapeutic Drugs at Environmental Levels on Human Embryonic Cells (2006)

The potential risk associated with the presence of low levels of pharmaceuticals in aquatic environments is currently under debate. In this study we investigated the effects of 13 drugs merged to mimic both the association and low concentration (ng/L) profiles detected in the environment. The mixture comprised atenolol, bezafibrate, carbamazepine, cyclophosphamide, ciprofloxacin, furosemide, hydrochlorothiazide, ibuprofen, lincomycin, ofloxacin, ranitidine, salbutamol, and sulfamethoxazole. At environmental exposure levels, the drug mix inhibited the growth of human embryonic cells HEK293, with the highest effect observed as a 30% decrease in cell proliferation compared to controls. Pharmaceuticals activated stress-response signaling protein kinases (ERK1/2), and induced overexpression of glutathione-S-transferase P1 gene. No evidence was found for apoptosis or necrosis in HEK293 cells, although morphological changes were observed. The drug mixture effectively stimulated the expression of cell-cycle progression-mediating genes p16 and p21, with a slight accumulation of cells in the G2/M phase of the cell-cycle. Our results suggest that a mixture of drugs at ng/L levels can inhibit cells proliferation by affecting their physiology and morphology. This also suggests that water-borne pharmaceuticals can be potential effectors on aquatic life.
Importance of semantic representation: dataless classification (2008)

Traditionally, text categorization has been studied as the problem of training of a classifier using labeled data. However, people can categorize documents into named categories without any explicit training because we know the meaning of category names. In this paper, we introduce Dataless Classification, a learning protocol that uses world knowledge to induce classifiers without the need for any labeled data. Like humans, a dataless classifier interprets a string of words as a set of semantic concepts. We propose a model for dataless classification and show that the label name alone is often sufficient to induce classifiers. Using Wikipedia as our source of world knowledge, we get 85.29% accuracy on tasks from the 20 Newsgroup dataset and 88.62% accuracy on tasks from a Yahoo! Answers dataset without any labeled or unlabeled data from the data sets. With unlabeled data, we can further improve the results and show quite competitive performance to a supervised learning algorithm that uses 100 labeled examples.
Demoralization in Parkinson disease (2018)

Demoralization is common in PD and is associated with motor dysfunction. In demoralization, there is a prominent inability to cope, making it somewhat distinct from depression. Treatment approaches are also different, making it important to identify demoralization in patients with PD.
Homogeneous Charge Compression Ignition (HCCI) of Diesel Fuel (1997)

<div class="htmlview paragraph">This paper describes the ongoing homogeneous charge compression ignition (HCCI) research being carried out at Southwest Research Institute (SwRI). Summaries of the results of testing to date are presented and discussed.</div> <div class="htmlview paragraph">HCCI is a process whereby a premixed charge of diesel fuel and air is admitted into the power cylinder and compression ignited. Ignition occurs homogeneously throughout the cylinder. HCCI reduces flame temperatures and oxides of nitrogen (NO<sub>x</sub>) emissions. The lack of fuel rich zones within the cylinder eliminates soot formation (1-pull Bosch smoke numbers of 0, 5-pull = 0). The limits of HCCI start of combustion timing are defined by knock before top dead center (BTDC) and misfire after top dead center (ATDC).</div> <div class="htmlview paragraph">Stable and repeatable HCCI combustion has been demonstrated over a wide range of air-fuel (A/F) ratios, intake temperatures, compression ratios (CR), exhaust gas recirculation (EGR) rates, and for two fuels. A/F ratios of 14 to 80 are possible. CRs of 8 to 13 have been demonstrated. EGR rates from 0 to 50 percent have been operated successfully. Results for ceramic coating of the piston crown, valves, and fire-deck have been compared to those of plain steel parts. Stable combustion for diesel fuel as well as a blended fuel (19 percent hexadecane, 81 percent heptane) has been demonstrated.</div> <div class="htmlview paragraph">While HCCI tests have yielded a higher indicated specific fuel consumption (ISFC) value than the direct-injection (DI)-diesel, results indicate a 98 percent reduction in NO<sub>X</sub> emissions for diesel-fueled HCCI over the DI-diesel configuration, and a reduction of 27 percent in particulates. They also reveal a strong dependence of particulate emissions on intake air temperature.</div>
Small Intestinal Permeability and Gut-Transit Time Determined with Low and High Molecular Weight Fluorescein Isothiocyanate-Dextrans in C3H Mice (2018)

Protocols for intestinal permeability measurements in mice using 4-kDa fluorescein isothiocyanate-conjugated (FITC) dextran differ considerably among laboratories on the blood-sampling time. To find the optimal point in time for blood sampling, we administered 4-kDa FITC dextran to C3H mice and monitored the marker in plasma over 8 h. We also determined gut-transit time using 70-kDa FITC dextran, which does not cross the intestinal epithelium. The 4-kDa FITC dextran concentration in plasma reached its maximum 45 min after administration. The 70-kDa FITC dextran reached the jejunum after 15 min and passed the entire small intestine within 1 h after its administration, demonstrating that 4-kDa FITC dextran measured in plasma 1 h after its oral application is a marker of small intestinal permeability.
A review on issues related to the implementation of turbo codes and space-time trellis codes (2005)

In this paper, a review of the fundamental principles of turbo coding and space-time trellis coding (STTC) is given. Turbo codes have a powerful error correction capability that approach Shannon's capacity limit, leading to increased data rates and improved quality of service. STTC on the other hand combine channel coding and the use of multiple transmit antennas to provide temporal and space diversity for improved performance of communication links in fading channels. The paper discusses the fundamentals of the two schemes with their performance verified with simulation results. The complexity and the computational challenges involved in the real-time implementation of turbo-codes and the STTC system using top performing DSP processors are investigated. The paper ends with an investigation on the feasibility of implementing a concatenated outer turbo-coding with an inner STTC coding
Observations of the Mechanisms of Electromediated DNA Uptake - From Vesicles to Tissues (2010)

We discuss experimental observations of DNA uptake induced by electropermeabilisation. First we describe how experiments on giant unilamelar vesicles can be used to understand the effect of electric fields on lipid membranes and the associated transfer of DNA across the plasma membrane. We then discuss how DNA interacts with electropermeabilised cells in culture and how gene expression is correlated to observations of interactions between DNA and the cell membrane. Finally we discuss how DNA uptake occurs and can be optimized for the most medically relevant case of tissues.
The induction of skin graft tolerance in major histocompatibility complex‐mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti‐CD4 and anti‐CD8 antibodies (1990)

Mice given short courses of anti-CD4 and anti-CD8 monoclonal antibodies became tolerant of allogeneic skin grafted at the same time. Tolerance could be obtained without T cell depletion across multiple minor antigen mismatches, both in naive and primed animals, demonstrating that peripheral T cells could be tolerized, even if they had been previously activated. Where donor and recipient were incompatible across the whole major histocompatibility complex, specific tolerance could be achieved by using a combination of depleting followed by non-depleting antibodies, where each alone was unsuccessful. Although mice clearly tolerated their original skin grafts, we observed in some strain combinations that a second fresh, but genotypically identical graft, was slowly rejected. Such mice also possessed T cells which could proliferate to donor-type stimulator cells in vitro. Whatever the mechanisms, we have demonstrated that operational transplantation tolerance can be achieved with simple, non-toxic antibody therapy. The introduction of comparable tolerance-inducing regimens in clinical organ transplantation could obviate the need for long-term immunosuppression and its unfortunate side effects.
Attenuation of Lung Inflammation and Fibrosis in Interferon-γ –Deficient Mice after Intratracheal Bleomycin (2001)

Because mouse strains susceptible to bleomycin, such as C57BL/ 6J, tend to produce T helper type 1 (Th1) cytokines in response to immune activation, we hypothesized that the inflammatory response to bleomycin is mediated, in part, by local production of the Th1 cytokine interferon-gamma (IFN-gamma). Consistent with this hypothesis, fibrosis-prone C57BL/6J and A/J mice demonstrated significantly elevated expression of IFN-gamma protein (by enzyme-linked immunosorbent assay) in bronchoalveolar lavage fluid at 24 h, and subsequently increased lung inflammation, weight loss, and mortality 10 d after intratracheal bleomycin administration compared with fibrosis-resistant BALB/c mice or saline control mice. To directly determine a role for IFN-gamma in bleomycin toxicity, we exposed C57BL/6J mice with a homozygous null mutation of the IFN-gamma gene (IFN-gamma[-/-]) and wild-type C57BL/6J mice to intratracheal bleomycin. IFN-gamma(-/-) mice demonstrated significantly lower parenchymal inflammation, weight loss, and mortality 10 d after 5 U/kg intratracheal bleomycin administration compared with control mice. At 3 wk after 1.5 U/kg bleomycin exposure, single lung collagen determined by hydroxyproline assay was significantly lower in IFN-gamma(-/-) mice compared with wild-type C57BL/6J mice. Together, these results suggest that IFN-gamma mediates, in part, bleomycin-induced pulmonary inflammation and fibrosis.