gebhart/patrepeval huggingface dataset:
Adaptive Trajectory Prediction Algorithm for Climbing Flights (2012)

Aircraft climb trajectories are difficult to predict, and large errors in these predictions reduce the potential operational benefits of some advanced features for NextGen. The algorithm described in this paper improves climb trajectory prediction accuracy by adjusting trajectory predictions based on observed track data. It utilizes rate-of-climb and airspeed measurements derived from position data to dynamically adjust the aircraft weight modeled for trajectory predictions. In simulations with weight uncertainty, the algorithm is able to adapt to within 3 percent of the actual gross weight within two minutes of the initial adaptation. The root-mean-square of altitude errors for five-minute predictions was reduced by 73 percent. Conflict detection performance also improved, with a 15 percent reduction in missed alerts and a 10 percent reduction in false alerts. In a simulation with climb speed capture intent and weight uncertainty, the algorithm improved climb trajectory prediction accuracy by up to 30 percent and conflict detection performance, reducing missed and false alerts by up to 10 percent.
Brain Serotonin Transporter Distribution in Subjects With Impulsive Aggressivity: A Positron Emission Study With [<sup>11</sup>C]McN 5652 (2005)

Pathological impulsive aggressivity might be associated with lower serotonergic innervation in the anterior cingulate cortex, a region that plays an important role in affective regulation.
Influence of time and phenotype on salivary Fel d1 in domestic shorthair cats (2019)

We observed a wide and continuous range of salivary Fel d1 production in domestic shorthair cats. In particular, a subset of cats had stable low levels throughout the course of the year, and they can be identified by analyzing a few saliva samples rather than their physical appearance.
Baculovirus Expression Vectors that Incorporate the Foreign Protein into Viral Occlusion Bodies (2003)

Current baculovirus expression systems typically produce soluble proteins that accumulate within the infected insect cell or are secreted into the growth medium. A system has now been developed for the incorporation of foreign proteins, along with the matrix protein, polyhedrin, into baculovirus occlusion bodies. Initial studies showed that a recombinant virus expressing a translational fusion between polyhedrin and GFP did not form occlusion bodies. However, a baculovirus coexpressing native polyhedrin and the polyhedrin-GFP fusion protein formed occlusion bodies that fluoresced under UV light, demonstrating that they included the polyhedrin-GFP fusion protein. This was confirmed by immunoblot analysis. Thus, incorporation of a foreign protein into occlusion bodies depends on an interaction between native polyhedrin and the polyhedrin fusion protein. Electron microscopy demonstrated that the occlusion bodies containing GFP also incorporated virions as expected. These ColorPol occlusion bodies were as infectious to insect larvae as occlusion bodies produced by wild-type virus. This new system expands the capabilities for foreign gene expression by baculoviruses, which has implications for biopesticide design, novel vaccine delivery systems, and fusion protein purification applications.
Pattern-Miner (2008)

This demo presents Pattern-Miner, an integrated environment for pattern management and mining that deals with the whole lifecycle of patterns, from their generation (using data mining techniques) to their storage and querying, putting also emphasis on the comparison between patterns and meta-mining operations over the extracted patterns. Pattern comparison (comparing results of the data mining process) and meta-mining are high level pattern operations that can be applied in a variety of applications, from database change management to image comparison and retrieval.
A Case Study on Developing Cloud of Things Devices (2015)

Manufacturing industries must develop valueadded products such as CoT (Cloud of Things) devices to maintain international competitiveness. CoT devices require methods for developing cloud services. We propose a common framework that can be used to rapidly develop CoT devices. Using this framework, a device can communicate with another device located in a different private network. In this paper, we describe the proposed common framework for CoT devices, using a smart light as an example, and evaluate the effectiveness of our method.
Multiple Linear Regression and Artificial Neural Network to Predict Blood Glucose in Overweight Patients (2016)

The level of fs-GLU was predictable using the proposed BP-ANN model based on 6 related parameters (age, fs-ALT, fs-BUN, fs-TP, fs-UA and BMI) in overweight patients.
Platelet-derived growth factor stimulates the secretion of hyaluronic acid by proliferating human vascular smooth muscle cells. (1995)

Total glycans from the cell layer and the culture medium of human vascular smooth muscle cells (VSMC) that had been cultivated in the presence of platelet-derived growth factor (PDGF) were isolated and purified by gel filtration after Pronase and DNase digestion and alkaliborohydride treatment. Measurements of the content of neutral hexoses and uronic acids revealed that PDGF stimulates total glycan synthesis by proliferating VSMC in a linear fashion from 24 h to 72 h of incubation. In contrast, total glycan synthesis by human fibroblasts, epithelial cells, or endothelial cells was not affected by PDGF, indicating cell-type specificity. Chemical, biochemical, and enzymological characterization of the total glycans synthesized by VSMC showed that PDGF stimulates the secretion of a 340-kDa glycan molecule in a time-dependent manner from 24 h to 72 h. This molecule is highly acidic, shares a common structure with hyaluronic acid, and exhibits a potent antiproliferative activity on VSMC. These results suggest that VSMC in response to PDGF are capable of controlling their own growth and migration by the synthesis of a specific form of hyaluronic acid with antiproliferative potency, which may be involved in the regulation of the local inflammatory responses associated with atherosclerosis.
Quasi-static axial cutting of AA6061 T4 and T6 round extrusions (2008)

A cutting deformation mode of AA6061 T4 and T6 round extrusions with two different wall thicknesses of 1.587 and 3.175 mm was experimentally investigated under quasi-static loading conditions. A heat treated 4140 steel alloy cutter was developed and used to initiate cutting deformation in the extrusions to investigate the load—displacement and energy absorption characteristics under uniaxial compressive loading. This research extended the observations associated with cutting deformation of lightweight extrusions already completed by the authors on AA6061 T6 tubes with a wall thickness of 3.175 mm. Clean cutting behaviour was observed for the extrusions with a T6 temper and wall thickness of 1.587 mm and for extrusions with a T4 temper and wall thickness of 3.175 mm. Extrusions with a T4 temper and wall thickness of 1.587 mm exhibited characteristics of braided cutting. An almost constant cutting force was observed for the cutting deformation mode, however, variations in the cutting force were observed for the AA6061 T4 extrusions with a wall thickness of 1.587 mm after approximately 50 mm crosshead displacement. The average total energy absorption (TEA), as a result of the cutting deformation, was observed to be 2.0 and 2.7 kJ for the AA6061 T4 and T6 extrusions with a wall thickness of 1.587 mm, respectively. Average TEA for the AA6061 T4 extrusions with a wall thickness of 3.175 mm was observed to be 4.2 kJ under the cutting deformation.
Use of 3‐nitrobenzonitrile as an additive for improved sensitivity in sonic‐spray ionization mass spectrometry (2014)

The use of 3-NBN with V-EASI-MS gives rise to a novel 3-NBN-assisted MS technique, which has demonstrated considerable signal enhancement for most of the compounds analyzed, thus improving its competitiveness towards the well-established and dominating ESI-MS technique.
Reactivity of Iron-based Oxygen Carriers Prepared by Wet and Dry Mixing Methods for Hydrogen Production Via Biomass Derived Syngas Chemical Looping (2014)

In the hydrogen production by chemical looping process using syngas derived from biomass, iron-based oxygen carriers are very important which can react with steam to produce pure hydrogen. In this paper, wet and dry mixing methods were used to prepare iron-based oxygen carriers supported on Al2O3. The mass ratio of Fe2O3 was 70% and all the Fe2O3/Al2O3 oxygen carriers were calcined at 950 °C for 6 h. H2-Temperature Programmed Reductions (TPR) and reduction reaction with H2 at temperatures range from 800 °C to 950 °C were carried out on a TGA. The results showed that 900 °C was the best temperature to realize the highest reduction conversion of oxygen carriers. Oxygen carriers prepared by both methods were further tested in a fixed bad reactor for 10 cycles to produce hydrogen. The results showed that particles prepared by dry mixing method had high reactivity in the hydrogen production by chemical looping in a fixed bed reactor which got the hydrogen yield about 2200 μmol H2/g Fe2O3.
Alterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonism (2011)

Cortico-basal ganglia-thalamocortical circuits are severely disrupted by the dopamine depletion of Parkinson's disease (PD), leading to pathologically exaggerated beta oscillations. Abnormal rhythms, found in several circuit nodes are correlated with movement impairments but their neural basis remains unclear. Here, we used dynamic causal modelling (DCM) and the 6-hydroxydopamine-lesioned rat model of PD to examine the effective connectivity underlying these spectral abnormalities. We acquired auto-spectral and cross-spectral measures of beta oscillations (10-35 Hz) from local field potential recordings made simultaneously in the frontal cortex, striatum, external globus pallidus (GPe) and subthalamic nucleus (STN), and used these data to optimise neurobiologically plausible models. Chronic dopamine depletion reorganised the cortico-basal ganglia-thalamocortical circuit, with increased effective connectivity in the pathway from cortex to STN and decreased connectivity from STN to GPe. Moreover, a contribution analysis of the Parkinsonian circuit distinguished between pathogenic and compensatory processes and revealed how effective connectivity along the indirect pathway acquired a strategic importance that underpins beta oscillations. In modelling excessive beta synchrony in PD, these findings provide a novel perspective on how altered connectivity in basal ganglia-thalamocortical circuits reflects a balance between pathogenesis and compensation, and predicts potential new therapeutic targets to overcome dysfunctional oscillations.
Electrocatalysis of Anodic Oxygen‐Transfer Reactions: Application of an Electrochemical Quartz Crystal Microbalance to a Study of Pure and Bismuth‐Doped Beta‐Lead Dioxide Film Electrodes (1990)

Ratios of the change in surface mass corresponding to a change in charge were determined for the electrodeposition of thin films of pure and Bi‐doped at Au‐film electrodes in , using an electrochemical quartz microbalance. The value obtained for pure films is in good agreement with the theoretical value of 1.24 mg C−1. A larger value, , obtained for the Bi‐doped films, is concluded to result from the co‐deposition of some with Bi(V) in the mixed‐oxide film. Bismuth(III) was determined to be anodically adsorbed as Bi(V) at pure surfaces for vs. with in and in . The electrodes with adsorbed Bi(V) are active for various anodic oxygen‐transfer reactions, including the oxidations of Mn(II) to and DMSO to . Experimental results are interpreted to be consistent with a mechanism proposed previously, in which the Bi(V) sites have a lower overpotential for anodic discharge of to produce . It has been proposed that adsorbed hydroxyl radicals (.OHads) generated in the evolution mechanism are consumed by oxygen‐transfer steps, required in many oxidation processes.
Delivery of poorly water soluble drug from swellable elementary osmotic pump and effect of formulation variables (2013)

An elementary osmotic pump (EOP) tablet for efficient delivery of poorly water-soluble drugs was designed and studied effect of composition factors The designed system, called swellable elementary osmotic pump (SEOP). Effect of composition factors on the release of drug from the SEOP tablets containing a poorly water-soluble drug, etodolac, have been studied. The release behaviour of drug from different formulations of this dosage form was studied at pH 6 8 for a period of 24 h The formulations were compared based on four comparative parameters namely D4h (total release after 24 h) t (lag time) RSQ (R square of zero order equation) and D (percentage deviation from zero order kinetics) The drug release profile from osmotic devices showed that the type of polymer in the core formulation can markedly affect the drug release Results showed that SEOP could be a novel way for the oral administration of poorly water soluble drug like etodolac.
Multiphasic control of hepatic protein degradation by regulatory amino acids. General features and hormonal modulation. (1987)

Previous studies with livers from fed rats perfused in the single-pass mode have shown that regulatory amino acids (Leu, Tyr, Gln, Pro, Met, His, and Trp) as a group as well as leucine alone inhibit deprivation-induced protein degradation optimally at 0.5 and 4 times (X) normal plasma amino acid concentrations. However, they lose inhibitory effectiveness almost completely within a narrow zone centered at normal (1 X) levels (Pösö, A. R., Wert, J. J., Jr., and Mortimore, G.E. (1982) J. Biol. Chem. 257, 12114-12120; Pösö, A. R., and Mortimore, G. E. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 4270-4274). We now report similar effects for tyrosine and glutamine and suggest that this multiphasic dose response is a general feature of the regulatory group. Insulin (2.4 micrograms h-1) selectively modulated the response by abolishing the zonal loss, whereas glucagon (10 micrograms h-1) blocked the initial inhibition (0.5 X); proteolytic suppression was restored at 4 X normal plasma levels. Although the zonal loss of inhibition at 1 X was associated with a near maximal increase in the volume density of macroautophagy, the vacuoles differed from those induced by stringent amino acid deprivation in containing 4.5-fold more smooth than rough endoplasmic reticulum and thus represented a separate population. Surprisingly, the leucine analog, L-alpha-hydroxyisocaproate, elicited multiphasic responses identical to those of L-leucine, including inhibition at 0.1 mM (equivalent to 0.5 X Leu). Inasmuch as alpha-ketoisocaproate is not effective at this concentration, the initial suppression of protein degradation could be mediated from a site that recognizes structural features common to leucine and its hydroxyl analog.
5.3 A 2×70W monolithic five-level Class-D audio power amplifier (2016)

The consumer electronics trends of miniaturization and portability have been pushing the integrated Class-D audio power amplifier (PA) market for a number of years. This creates opportunities for new players in the market, through reduction of output LC filter size and reduction of power losses. In battery-powered applications, near-idle power loss is of particular interest, since the audio PA will typically run almost idle.
IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunity <i>in vivo</i> (2008)

Th17 cells have been recognized as the central effectors in organ-related autoimmune diseases. IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of TGF-beta induced Foxp3 and induction of RORgammat, a Th17 lineage-specific transcription factor. Recently IL-21 has been suggested to induce RORgammat and Th17 development in the absence of IL-6. However, the relevance of IL-21 for Th17-dependent inflammatory responses in vivo remains unclear. In this study, we demonstrate that differentiation of IL-17-producing CD4 T cells, their recruitment to inflamed organs, and the development of autoimmune disease was not affected in il21R(-/-) and il21(-/-) mice in models of myelin oligodendrocyte glycoprotein-induced autoimmune encephalitis and autoimmune myocarditis. IL-6 induced Th17 differentiation independent of and much more potently than IL-21 in vitro. These data suggest that IL-6 is sufficient to drive Th17 development and associated autoimmunity in vivo in the absence of IL-21 or IL-21R.
Synergistic effect of dehydroascorbic acid and mixtures with vitamin E and beta-carotene on mitomycin C efficiency under irradiation in vitro. (2005)

Experiments in vitro have shown that dehydroascorbic acid (DHA) possesses antitumor properties under irradiation, which are gradually enhanced by combination with beta-carotene or vitamin E. On the other hand the cytostatic efficiency of mitomycin C (MMC) is increased from deltaD37 = -93 up to deltaD37 = -141 in the presence of DHA. It has also been shown that Escherichia coli bacteria are able, to some extent, to reduce DHA to ascorbate under the same experimental conditions. The results are of interest for the radiation therapy of cancer.
Optimal bypass monitor for high performance last-level caches (2012)

In the last-level cache, large amounts of blocks have reuse distances greater than the available cache capacity. Cache performance and efficiency can be improved if some subset of these distant reuse blocks can reside in the cache longer. The bypass technique is an effective and attractive solution that prevents the insertion of harmful blocks.
New peak-to-average power-ratio reduction algorithms for OFDM systems using constellation extension (2005)

New peak-to-average power-ratio reduction (PAPR) algorithms for orthogonal frequency-division multiplexing systems are investigated in a probabilistic framework. Specifically, two de-randomization algorithms for PAPR reduction are developed by applying the so-called conditional probability method. Our simulations demonstrate that the proposed algorithms outperform several existing algorithms and the computational complexity of the proposed algorithms is found to be significantly less than that of existing algorithms.
Abstract 16417: Bone Marrow Transplants From NOX2-Deficient Mice To WT Mice Protect Against Diabetes-Induced Vascular Endothelial Dysfunction Through Decreased Arginase Activity (2011)

Increased arginase activity has been implicated in diabetes-induced vascular dysfunction by reducing L-arginine bioavailability and nitric oxide production. Our lab previously reported that inhibit...
Aryl Sulfate is a Useful Motif for Conjugating and Releasing Phenolic Molecules: Sulfur Fluorine Exchange Click Chemistry Enables Discovery of Ortho-Hydroxy-Protected Aryl Sulfate Linker (2019)

A new self-immolative linker motif, Ortho Hydroxy-Protected Aryl Sulfate (OHPAS), was devised, and OHPAS-containing antibody drug conjugates (ADC) were tested in vitro and in vivo. Conveniently synthesized using Sulfur Fluorine Exchange (SuFEx) chemistry, it is based structurally on diaryl sulfate, with one aryl acting as a payload and the other as a self-immolative sulfate unit having a latent phenol function at the ortho position. The chemically stable OHPAS linker was stable in plasma samples from 5 different species, yet it can release the payload molecule smoothly upon chemical or biological triggering. The payload release proceeds via intramolecular cyclization, producing a cyclic sulfate coproduct that eventually hydrolyzes to a catechol monosulfate. A set of OHPAS-containing ADCs based on Trastuzumab were prepared with a drug to antibody ratio of ∼2, and were shown to be cytotoxic in 5 different cancer cell lines in vitro and dose-dependently inhibited tumor growth in a NCI-N87 mouse xenograft model. We conclude that OHPAS conjugates will be of considerable use for delivering phenol-containing payloads to tissues targeted for medical intervention.
Two-Stage Pre-Training for Sequence to Sequence Speech Recognition (2021)

The attention-based encoder-decoder structure is popular in automatic speech recognition (ASR). However, it relies heavily on transcribed data. In this paper, we propose a novel pre-training strategy for the encoder-decoder sequence-to-sequence (seq2seq) model by utilizing unpaired speech and transcripts. The pre-training process consists of two stages, acoustic pre-training and linguistic pre-training. In the acoustic pre-training stage, we use a large amount of speech to pre-train the encoder by predicting masked speech feature chunks with their contexts. In the linguistic pre-training stage, we first generate synthesized speech from a large number of transcripts using a text-to-speech (TTS) system and then use the synthesized paired data to pre-train the decoder. The two-stage pre-training is conducted on the AISHELL-2 dataset, and we apply this pre-trained model to multiple subsets of AISHELL-1 and HKUST for post-training. As the size of the subset increases, we obtain relative character error rate reduction (CERR) from 38.24% to 7.88% on AISHELL-1 and from 12.00% to 1.20% on HKUST.
NKT Cell Networks in the Regulation of Tumor Immunity (2014)

CD1d-restricted natural killer T (NKT) cells lie at the interface between the innate and adaptive immune systems and are important mediators of immune responses and tumor immunosurveillance. These NKT cells uniquely recognize lipid antigens, and their rapid yet specific reactions influence both innate and adaptive immunity. In tumor immunity, two NKT subsets (type I and type II) have contrasting roles in which they not only cross-regulate one another, but also impact innate immune cell populations, including natural killer, dendritic, and myeloid lineage cells, as well as adaptive populations, especially CD8(+) and CD4(+) T cells. The extent to which NKT cells promote or suppress surrounding cells affects the host's ability to prevent neoplasia and is consequently of great interest for therapeutic development. Data have shown the potential for therapeutic use of NKT cell agonists and synergy with immune response modifiers in both pre-clinical studies and preliminary clinical studies. However, there is room to improve treatment efficacy by further elucidating the biological mechanisms underlying NKT cell networks. Here, we discuss the progress made in understanding NKT cell networks, their consequent role in the regulation of tumor immunity, and the potential to exploit that knowledge in a clinical setting.
Liao, Rong-li (2014)

Rong-li Liao (1936–2010) was a psychiatric social worker and educator. He was a professor in the Department of Sociology and Social Work at the National Taiwan University from 1970 to 1996 and helped to organize the Medical Social Work Association of R. O. C. (Taiwan).
Phonon Dispersion of an Epitaxial Monolayer Film of Hexagonal Boron Nitride on Ni(111) (1997)

Phonon spectra for epitaxial monolayer films of hexagonal boron nitride $(h\ensuremath{-}\mathrm{BN})$ on Ni, Pd, and Pt (111) have been measured for the first time by using high resolution electron energy loss spectroscopy. On Ni(111), we have found two remarkable features in the observed dispersion curves: a level splitting at the crossing point of two phonon branches and degeneracy of two optical phonons with in-plane polarization at $\overline{\ensuremath{\gamma}}$, which means the rumpled structure of the $h\ensuremath{-}\mathrm{BN}$ film and the elimination of electric fields parallel to the film, respectively.