gebhart/patrepeval huggingface dataset:
618: Costimulatory B7-H1 In Renal Cell Carcinoma Patients: Indicator of Tumor Aggressiveness and Potential Therapeutic Target (2005)

You have accessJournal of UrologyDiscussed Poster, Monday, May 23, 2005, 8:00 am - 12:00 pm1 Apr 2005618: Costimulatory B7-H1 In Renal Cell Carcinoma Patients: Indicator of Tumor Aggressiveness and Potential Therapeutic Target R. Houston Thompson, Michael D. Gillett, John C. Cheville, Christine M. Lohse, Haidong Dong, W. Scott Webster, Kent G. Krejci, John R. Lobo, Shomik Sengupta, Lieping Chen, Horst Zincke, Michael L. Blute, Scott E. Strome, Bradley C. Leibovich, and Eugene D. Kwon R. Houston ThompsonR. Houston Thompson More articles by this author , Michael D. GillettMichael D. Gillett More articles by this author , John C. ChevilleJohn C. Cheville More articles by this author , Christine M. LohseChristine M. Lohse More articles by this author , Haidong DongHaidong Dong More articles by this author , W. Scott WebsterW. Scott Webster More articles by this author , Kent G. KrejciKent G. Krejci More articles by this author , John R. LoboJohn R. Lobo More articles by this author , Shomik SenguptaShomik Sengupta More articles by this author , Lieping ChenLieping Chen More articles by this author , Horst ZinckeHorst Zincke More articles by this author , Michael L. BluteMichael L. Blute More articles by this author , Scott E. StromeScott E. Strome More articles by this author , Bradley C. LeibovichBradley C. Leibovich More articles by this author , and Eugene D. KwonEugene D. Kwon More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34858-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "618: Costimulatory B7-H1 In Renal Cell Carcinoma Patients: Indicator of Tumor Aggressiveness and Potential Therapeutic Target." The Journal of Urology, 173(4S), p. 169 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 169 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information R. Houston Thompson More articles by this author Michael D. Gillett More articles by this author John C. Cheville More articles by this author Christine M. Lohse More articles by this author Haidong Dong More articles by this author W. Scott Webster More articles by this author Kent G. Krejci More articles by this author John R. Lobo More articles by this author Shomik Sengupta More articles by this author Lieping Chen More articles by this author Horst Zincke More articles by this author Michael L. Blute More articles by this author Scott E. Strome More articles by this author Bradley C. Leibovich More articles by this author Eugene D. Kwon More articles by this author Expand All Advertisement Loading ...
Crane operation using hand-motion and radio frequency identification tags (2009)

Payload oscillation inherent to all cranes makes it challenging for human operators to manipulate payloads quickly, accurately, and safely. Manipulation difficulty is also increased by non-intuitive crane control interfaces. A new type of crane control interface that allows an operator to drive a crane by moving his or her hand freely in space has been implemented on an industrial bridge crane. Real-time-location technology based on radio frequency sensors tracks the 3D movements of a small tag held in the operator's hand. The tag's position is then used to drive the crane. Simulations of the crane dynamics and hand-motion control were compared with actual experimental data. The results show that a combination of aggressive PD feedback control gains and an input shaper is able to generate the desired characteristics of fast crane response and low residual oscillations.
Cloning of nicotianamine synthase genes from<i>Arabidopsis thaliana</i> (1999)

Abstract Nicotianamine synthase (NAS) catalyzes the trimerization of S-adenosylmethionine to form one molecule of nicotianamine (NA). NA is present in all the plants; it chelates metal cations, and is considered to play a role in metal homeostasis in plants. Moreover, in graminaceous monocotyledonous plants, NA is an essential intermediate in the biosynthesis of mugineic acid family phytosiderophores (MAs). In order to identify the gene encoding NAS in dicotyledonous plants, Arabidopsis thaliana databases were searched using the nucleotide sequence of the NAS gene from barley (HvNAS), which we have recently isolated. We found several ESTs and three genomic sequences highly homologous to HvNAS in the databases. Based on these nucleotide sequences and that of HvNAS, we designed 2 sets of primers to isolate the NAS orthologues in Arabidopsis and succeeded in obtaining three DNA clones encoding AtNAS (AtNAS1, 2, and 3). These clones were expressed in Escherichia coli and their protein products displayed the NAS activity. The expression of AtNASl was detected in both shoots and roots of A. thaliana by RT-PCR; AtNAS3 expression was only detected in the shoots. In contrast, AtNAS2 expression was not detected in any organs.
Neuron‐glia communication: metallothionein expression is specifically up‐regulated by astrocytes in response to neuronal injury (2003)

Recent data suggests that metallothioneins (MTs) are major neuroprotective proteins within the CNS. In this regard, we have recently demonstrated that MT-IIA (the major human MT-I/-II isoform) promotes neural recovery following focal cortical brain injury. To further investigate the role of MTs in cortical brain injury, MT-I/-II expression was examined in several different experimental models of cortical neuron injury. While MT-I/-II immunoreactivity was not detectable in the uninjured rat neocortex, by 4 days, following a focal cortical brain injury, MT-I/-II was found in astrocytes aligned along the injury site. At latter time points, astrocytes, at a distance up to several hundred microns from the original injury tract, were MT-I/-II immunoreactive. Induced MT-I/-II was found both within the cell body and processes. Using a cortical neuron/astrocyte co-culture model, we observed a similar MT-I/-II response following in vitro injury. Intriguingly, scratch wound injury in pure astrocyte cultures resulted in no change in MT-I/-II expression. This suggests that MT induction was specifically elicited by neuronal injury. Based upon recent reports indicating that MT-I/-II are major neuroprotective proteins within the brain, our results provide further evidence that MT-I/-II plays an important role in the cellular response to neuronal injury.
Fault prediction in aircraft engines using Self-Organizing Maps (2009)

Aircraft engines are designed to be used during several tens of years. Their maintenance is a challenging and costly task, for obvious security reasons. The goal is to ensure a proper operation of the engines, in all conditions, with a zero probability of failure, while taking into account aging. The fact that the same engine is sometimes used on several aircrafts has to be taken into account too. The maintenance can be improved if an efficient procedure for the prediction of failures is implemented. The primary source of information on the health of the engines comes from measurement during flights. Several variables such as the core speed, the oil pressure and quantity, the fan speed, etc. are measured, together with environmental variables such as the outside temperature, altitude, aircraft speed, etc. In this paper, we describe the design of a procedure aiming at visualizing successive data measured on aircraft engines. The data are multi-dimensional measurements on the engines, which are projected on a self-organizing map in order to allow us to follow the trajectories of these data over time. The trajectories consist in a succession of points on the map, each of them corresponding to the two-dimensional projection of the multi-dimensional vector of engine measurements. Analyzing the trajectories aims at visualizing any deviation from a normal behavior, making it possible to anticipate an operation failure.
Novel Cyanide Free Electroless Au Plating for the Reliable Joint Between Ni-P/Au and Sn-Ag-Cu Based Lead Free Solder (2005)

Novel cyanide free electroless Au plating with an excellent bath stability and the reliable joint with solder was developed. Although the Au plating solution was based on sulfurous acid, the solution’s stability turned out to be excellent by the effective complexing force of the novel additives. The bath stood working without any precipitations for more than 3 metal turnovers. Since the displacement reaction between Ni-P and Au took place in the mild and the uniform way by the aid of the additives involved, resulting in the uniform and the fine grain structure of the plated film, almost no pinholes on the Au plating layer and no pitting corrosion in the ground Ni-P layer could be observed. The joint strength between the BGA pad plated with this novel Ni-P/Au plating and Sn-Ag-Cu based lead free solder ball was found to be much higher than that obtained by the conventional cyanide process. The excellent joint reliability of this process was probably due to the fact that the uniform Au layer with almost no pinholes effectively suppressed the oxidation of the Ni-P surface and eventually almost no pitting corrosion was produced in the Ni-P layer without forming any fatal voids.
L<sub>1</sub> adaptive controller for nonlinear systems in the presence of unmodelled dynamics: Part II (2008)

This paper presents a novel adaptive control methodology for a class of uncertain nonlinear systems in the presence of unmodelled dynamics. The adaptive controller ensures uniformly bounded transient response for system’s both input and output signals simultaneously. The performance bounds can be systematically improved by increasing the adaptation gain.
An Optoelectronic Switch Based on Intrinsic Dual Schottky Diodes in Ambipolar MoSe<sub>2</sub> Field‐Effect Transistors (2015)

The observation of a previously unreported optoelectronic effect, namely, a light‐induced diode‐like response in multilayered MoSe 2 field‐effect transistors is reported. It has a sense of current rectification that is controllable through a gate voltage. It is argued, using numerical simulations, that this behavior results from the difference in the size of the Schottky barriers between the drain and source metal contacts. Each barrier can be modeled as a Schottky diode but with opposite senses of current rectification between them, with the diode response resulting from the light induced promotion of photogenerated carriers across the smaller barrier. The back gate voltage controls the sense of current rectification by modulating the relative amplitude between them. This effect, which gives rise to a novel type of optoelectronic switch, also yields a photovoltaic response. Hence, it can provide an alternative to p–n junctions when harvesting photovoltaic currents from transition metal dichalcogenides. It is argued that the photovoltaic efficiency associated to this effect can be increased by just increasing the relative asymmetry between both Schottky barriers. It is also suggested that this new electro‐optical effect has potential for technological applications.
Noisy password security technique (2009)

One-time password makes it more difficult to gain unauthorized access to restricted resources. In our previous work we designed a one-time password scheme that implements our noisy password scheme. The previous work proved to be a secure password entry scheme, but was somehow difficult for users. In this paper, we propose a technique for improving the security of password-based applications by incorporating predefined keystroke patterns into the password. The proposed system attempts to alleviate the problem of shoulder surfing by inserting different noise patterns in the password making. The user is authenticated by totally different password every time. The noisy password constitute of several parts, the actual password and additional noisy parts. Different password parts will be entered using keystroke patterns not characters. The noisy parts are proven to be robust against any hacking attacks. Experimental results give good indication of the ease of utilization of the new system with low error rates.
Porphyrin‐Perylene Dyes for Dye‐Sensitized Solar Cells (2010)

Abstract Two novel porphyrin‐perylene dyads 1 and 2 for DSSC applications have been synthesized. The absorption band of the perylene fills up the trough between the Soret and Q bands of the porphyrin, leading to an increase in the absorption efficiency of the dye. The highly conjugated acetylenic bridge mediates strong electronic coupling between the porphyrin and perylene units and results in the extension of π‐conjugation of the porphyrin ring. The Soret and Q bands are broadened and red‐shifted and the light‐harvesting effect is thus improved. We propose that energy transfer occurs from the photoexcited perylene to porphyrin for dyad 1 whereas energy transfer proceeds from the excited porphyrin to perylene for dyad 2 . Our studies show that multichromophoric dyes used for DSSC can be designed in a rational manner with predictable photophysical behavior and efficient light‐harvesting properties, but the efficiency of the energy transfer process in a consecutive model needs to be controlled for a significant improvement of the cell performance using perylene‐porphyrin sensitizers.
Differential Testing of Certificate Validation in SSL/TLS Implementations (2019)

Certificate validation in Secure Sockets Layer or Transport Layer Security protocol (SSL/TLS) is critical to Internet security. Thus, it is significant to check whether certificate validation in SSL/TLS implementations is correctly implemented. With this motivation, we propose a novel differential testing approach that is based on the standard Request for Comments (RFC). First, rules of certificates are extracted automatically from RFCs. Second, low-level test cases are generated through dynamic symbolic execution. Third, high-level test cases, i.e., certificates, are assembled automatically. Finally, with the assembled certificates being test cases, certificate validations in SSL/TLS implementations are tested to reveal latent vulnerabilities or bugs. Our approach named RFCcert has the following advantages: (1) certificates of RFCcert are discrepancy-targeted, since they are assembled according to standards instead of genetics; (2) with the obtained certificates, RFCcert not only reveals the invalidity of traditional differential testing but also is able to conduct testing that traditional differential testing cannot do; and (3) the supporting tool of RFCcert has been implemented and extensive experiments show that the approach is effective in finding bugs of SSL/TLS implementations. In addition, by providing seed certificates for mutation approaches with RFCcert, the ability of mutation approaches in finding distinct discrepancies is significantly enhanced.
New coupled-inductors current-doubler topology (2003)

Point-of-load DC-DC converters for current and next generation of ICs for communication systems and microprocessors are increasingly becoming stricter than ever. This is due to the required tight dynamic tolerances allowed for supply voltages and high dynamic performance demand coupled with very high power density. A new coupled-inductors current-doubler topology is proposed in this paper. The advantages of the proposed topology include higher voltage step-down ratio suitable for lower output voltages, better current ripple cancellation resulting in lower output current ripple, smaller isolation transformer turns ratio and lower secondary turns current when used in isolated topology, and can be designed to achieve symmetric transient response at both step-up and step-down transients when used in nonisolated topology. Theoretical analysis and simulation results are presented, and verified by experimental results.
Subcutaneous detection of acute myocardial infarction &#x2014; preliminary results (2008)

The early detection of acute myocardial infarction (AMI) is a critical success factor in the treatment of patients suffering from it. In order to prevent patients from delaying seeking medical care, a subcutaneous AMI detection and alerting device is proposed. Pre-clinical data from experiments with acute ischemic pig models show that it is possible to capture ECG changes resulting from acute coronary artery occlusion with a subcutaneously implanted single lead ECG recorder. Moreover, these ECG changes correspond well with the simultaneously recorded surface ECG.
The Characterization of Drug-to-Antibody Ratio and Isoforms of ADCs Using LC and MS Technologies (2017)

Hydrophobic interaction chromatography (HIC) and MS are leading techniques for the characterization of the critical quality attributes (CQA) of antibody-drug conjugates (ADCs). This includes the average drug-to-antibody ratio (DAR) and drug loading distribution. A workflow that effectively utilizes the synergy between chromatography and detection technologies has been developed and was assessed using cysteine-conjugated ADCs. The DAR of low, moderate and high drug-loaded ADC samples were calculated from the chromatographic peak areas using LC(HIC)/UV or the deconvoluted mass spectra using native LC(SEC)/MS. The results of DAR by both technologies produced comparable results. In addition, the 2D-LC/MS system has been evaluated in combination with HIC and reversed-phase chromatography for structural identification. Individual peaks from the 1st dimension of the HIC separation were isolated online and re-directed to the 2nd dimension reversed-phase column. ADC was detected as the sub-units by MS and the conjugation site was identified via a middle down approach.
Subjective quality analyses of stereoscopic images in 3DTV system (2011)

Subjective quality evaluation is the basis of quality evaluation of stereoscopic images. As the lack of a public and diverse testing database currently, in this paper, a symmetric stereoscopic images database is built. And then the subjective quality of stereoscopic images is analyzed from two aspects, one is the effects of JPEG, JPEG2000, H.264. The other is the comparisons between symmetric and asymmetric stereoscopic images from Gaussian blurring, white Gaussian noise, JPEG and JPEG2000, respectively. The results show three compressions are quite different in the subjective quality of symmetric stereoscopic images at different bitrates, and the comparisons between symmetric and asymmetric stereoscopic images investigate the properties of binocular fusion, binocular suppression, and binocular summation.
Effect of S Content on the MnS Precipitation in Steel with Oxide Nuclei. (1996)

Manganese sulphide formation experiments were carried out by deoxidizing with various elements and by changing S content to clarify the effect of S content n the MnS precipitation with various kinds of oxide nuclei. The behabvior of MnS precipitation on oxide particles in the steel with 1 mass% of Mn was characterized according to S content. When S content was below 100 ppm, a lot of MnS precipitated only on some kinds of oxide. It is effective to use an oxide having high sulphide capacity and low melting temperature for uniform dispersion of fine MnS. On the other hand, when S was above 100 ppm, almost all the oxides worked as the precipitation sites of MnS. In that case, for the MnS dispersion, it is better to select the oxide which tends to disperse finely itself in steel. The average diameter of MnS, calculated by using a mathematical model considering the oxide nuclei with changing the precipitation ratio according to S content and to the kind of oxides, agrees well with the experimental data.
Existence of Flow Barriers Improves Horizontal Well Production in Bottom Water Reservoirs (2008)

Abstract In developing heavy oil from thin bottom water reservoirs, horizontal wells are mostly used in Bohai Bay, China. To maximize oil production and avoid early water coning/cresting, horizontal wells are usually placed near the top of pay sands and wells are initially produced with small pressure drawdown. However, the production responses from different wells display significant variations even though they are operated under similar conditions. Some wells show premature water coning and rapid water cut rising although high quality sands are targeted, while others show much delayed water breakthrough and slower water cut increases. A series of reservoir simulations have been conducted to investigate the observed differences. The simulation results reveal that the existence of thin low permeable flow barriers with limited lateral extension/continuity between the wellbore and water/oil contact plays the most crucial role impacting the water coning characteristics. Wells with such flow barriers display later water breakthrough with steady increase of water cut after breakthrough, while wells without such barriers show quick water coning with water cut reaching more than 90% rapidly. The existence of low permeability barriers between the water/oil contact and horizontal wells could slow down water coning and result in much favorable production performance. This phenomenon is then verified by simulations and actual field data from QHD32-6 field. The accurate predictions of production performance rely on the knowledge of physical distribution of flow barriers relative to the wellbore location. In practice, lateral thin flow barriers are usually at sub-seismic scales, and thus hard to identify for a green field. However, for infill drilling in mature fields with many vertical wells drilled, it is possible to predict/correlate the spatial distribution of such flow barriers from the logs of existing wells. Based on such analysis, we can optimize the locations of horizontal infill wells to make full use of the flow barriers for improving production. A number of horizontal infill wells were optimized and drilled in QHD32-6 field, Bohai Bay, China after identifying flow barriers from the nearby vertical wells. These wells display good production performance having significant higher oil production with delayed water breakthrough and slower increase of water cut.
Colloidal thiophosphorus calcium salt as antiwear additive (1996)

Abstract This paper describes the synthesis of an oil‐soluble colloidal calcium thiophosphate by a direct route. It consists of the reaction of calcium oxide or hydroxide with tetraphosphorus decasulphide and water in the presence of a surfactant such as a calcium alkylaryl sulphonate in an organic medium. Reaction and micellisation occurred simultaneously according to a one‐step process. The product is characterised by a high calcium, phosphorus and sulphur content. The colloidal nature of the product has been confirmed by dialysis. The 31 P‐NMR spectrum showed signals characteristic of a blend of different calcium thiophosphates, plus calcium phosphate. The product could be defined as a core of different calcium (thio)phosphates surrounded by a calcium alkylaryl sulphonate shell, according to a reverse micelle type association in oil. This compound was evaluated as an antiwear additive in a 130 Neutral Solvent mineral oil by anti‐wear and extreme‐pressure four‐ball tests. The extreme‐pressure characteristics depend on the concentration of mineral colloidal core in oil. The antiwear properties are a function not only of the concentration, but also of the colloidal core/surfactant shell ratio. Thermogravimetric analysis of these colloidal species shows a weight loss in the 350°C to 450°C range, due to surfactant degradation. The further evolution of weight loss up to 900°C demonstrates the high thermal stability of the colloidal calcium (thio)phosphate core.