gebhart/patrepeval huggingface dataset:
Segmentation of hand radiographs using fast marching methods (2006)

Rheumatoid Arthritis is one of the most common chronic diseases. Joint space width in hand radiographs is evaluated to assess joint damage in order to monitor progression of disease and response to treatment. Manual measurement of joint space width is time-consuming and highly prone to inter- and intra-observer variation. We propose a method for automatic extraction of finger bone boundaries using fast marching methods for quantitative evaluation of joint space width. The proposed algorithm includes two stages: location of hand joints followed by extraction of bone boundaries. By setting the propagation speed of the wave front as a function of image intensity values, the fast marching algorithm extracts the skeleton of the hands, in which each branch corresponds to a finger. The finger joint locations are then determined by using the image gradients along the skeletal branches. In order to extract bone boundaries at joints, the gradient magnitudes are utilized for setting the propagation speed, and the gradient phases are used for discriminating the boundaries of adjacent bones. The bone boundaries are detected by searching for the fastest paths from one side of each joint to the other side. Finally, joint space width is computed based on the extracted upper and lower bone boundaries. The algorithm was evaluated on a test set of 8 two-hand radiographs, including images from healthy patients and from patients suffering from arthritis, gout and psoriasis. Using our method, 97% of 208 joints were accurately located and 89% of 416 bone boundaries were correctly extracted.
Improving LSF quantization performance with sorting (2005)

All coders require that the used linear prediction (LP) filter is stable. All current line spectral frequency (LSF) vector quantization routines may cause that the resulting quantized LSF vector is out of order, and thus unstable. In those cases the vector is stabilized after the quantization by sorting the LSF vector. This, however, means that the found vector may not be optimal, since this sorting was not taken into account in the quantization loop. The proposed codebook search routine orders the LSF vector inside the quantizer loop, and the optimal code vector is always found. The proposed method improves LSF quantization performance in terms of spectral distortion (SD) while maintaining the original bit allocation. The method can be used both with predictive and non-predictive split (partitioned) vector or multistage vector quantizers. The proposed method has more effect on performance when higher order LPC models or matrix quantizers are used, because in those cases LSFs are closer to each other and invalid ordering is more likely to happen. The proposed method is used in Texas Instruments, Nokia, and Ericsson ITU-4k candidate speech coder [A. McCree et al., May 2002].
A Computer Vision Approach to Automatically Measure the Initial Spin-Rate of Artillery Projectiles Painted With Stripes (2014)

Abstract High-speed video has been used by ballistics engineers as a cost-effective technique to measure the spin-rates of both spin-stabilized and fin-stabilized artillery projectiles. Often at test ranges, state-of-the-art video systems are used to verify critical launch events following muzzle exit. From manual analysis of these videos, important performance metrics such as velocity, pitch angle, and spin-rate can be estimated. To do this, operators step through the video frames and record the time at which certain fiducial markings or numbered stripes are observed on the projectile as it rotates. The different methods evaluated in this paper are automated processes for calculating the muzzle-exit spin-rate from launch videos of spin-stabilized artillery projectiles painted with stripes. Image processing and computer vision techniques are employed to segment the shape of the projectile and extract the stripe pattern in each video frame. The most accurate algorithm estimates are validated to within 0.02 % for both laboratory and computer-simulated flight video and within 0.13 % for manual analysis of real flight video. The sensitivities of the methods to image resolution, video frame-rate, and the length of flight captured are evaluated. Areas of continued research and recommendations for increasing the accuracy of measurements in future tests are also identified.
Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity (2011)

Type 1 or invariant NKT (iNKT) cell agonists, epitomized by α-galactosylceramide, protect against cancer largely by IFN-γ-dependent mechanisms. Here we describe what we believe to be a novel IFN-γ-independent mechanism induced by β-mannosylceramide, which also defines a potentially new class of iNKT cell agonist, with an unusual β-linked sugar. Like α-galactosylceramide, β-mannosylceramide directly activates iNKT cells from both mice and humans. In contrast to α-galactosylceramide, protection by β-mannosylceramide was completely dependent on NOS and TNF-α, neither of which was required to achieve protection with α-galactosylceramide. Moreover, at doses too low for either alone to protect, β-mannosylceramide synergized with α-galactosylceramide to protect mice against tumors. These results suggest that treatment with β-mannosylceramide provides a distinct mechanism of tumor protection that may allow efficacy where other agonists have failed. Furthermore, the ability of β-mannosylceramide to synergize with α-galactosylceramide suggests treatment with this class of iNKT agonist may provide protection against tumors in humans.
A Clone-Array Pooled Shotgun Strategy for Sequencing Large Genomes (2001)

A simplified strategy for sequencing large genomes is proposed. Clone-Array Pooled Shotgun Sequencing (CAPSS) is based on pooling rows and columns of arrayed genomic clones, for shotgun library construction. Random sequences are accumulated, and the data are processed by sequential comparison of rows and columns to assemble the sequence of clones at points of intersection. Compared with either a clone-by-clone approach or whole-genome shotgun sequencing, CAPSS requires relatively few library constructions and only minimal computational power for a complete genome assembly. The strategy is suitable for sequencing large genomes for which there are no sequence-ready maps, but for which relatively high resolution STS maps and highly redundant BAC libraries are available. It is immediately applicable to the sequencing of mouse, rat, zebrafish, and other important genomes, and can be managed in a cooperative fashion to take advantage of a distributed international DNA sequencing capacity.
Use of solvent extraction in the production of the ammonium salt of 3,5-dinitro-1,2,4-triazole (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of solvent extraction in the production of the ammonium salt of 3,5-dinitro-1,2,4-triazoleKien Y. Lee, Donald G. Ott, and Mary M. StinecipherCite this: Ind. Eng. Chem. Process Des. Dev. 1981, 20, 2, 358–360Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/i200013a027https://doi.org/10.1021/i200013a027research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Rapid Inactivation of Prostaglandin Endoperoxide Synthases by N-(Carboxyalkyl)maleimides (1994)

N-(Carboxyalkyl)maleimides were synthesized as potential inhibitors of prostaglandin endoperoxide synthase (PGHS). Inactivation of the cyclooxygenase and peroxidase activities of PGHS occurred in a biphasic manner with extremely rapid inactivation followed by slow, time-dependent inactivation. The carboxylic acid moiety was required for rapid inactivation. Optimal inhibition was observed with N-(carboxyheptyl)maleimide, which inhibited the cyclooxygenase activity of ovine PGHS-1 with an IC50 of 0.1 microM and the peroxidase activity with an IC50 of 3 microM. Inactivation of peroxidase activity was not prevented by pretreating the enzyme with the cyclooxygenase inhibitor indomethacin. N-(Carboxyheptyl)-succinimide inhibited neither enzyme activity, suggesting that covalent modification is critical for rapid as well as time-dependent inactivation. Shortening or increasing the alkyl chain by one methylene unit drastically reduced inhibitory potency. N-(Carboxyalkyl)maleimides also instantaneously inactivated the inducible form of PGHS (PGHS-2) from mouse and human sources but with higher IC50's (4.5 and 14 microM, respectively). N-(Carboxyheptyl)maleimide is the most potent covalent inactivator of PGHS yet described with an inhibitory potency 3-5 orders of magnitude greater than aspirin.
Mitochondrial dysfunction in diabetes mellitus (1999)

This review discusses the hypothesis that mitochondrial dysfunction plays a role in the pathogenesis of the most common form of diabetes, type II diabetes mellitus. Mitochondrial mutations have been linked to the development of diabetes mellitus as part of several rare syndromes, accounting for approximately 1.5% of all cases of the disease (“classic” mitochondrial diabetes). The characteristics of classic mitochondrial diabetes are intermediate between those of type I and type II diabetes, more closely resembling the latter. By studying the biochemical, cellular, and physiologic consequences of mitochondrial DNA mutations that cause classic mitochondrial diabetes, we may also gain important insights into the pathogenesis of type II diabetes mellitus. Individuals with classic mitochondrial diabetes exhibit a variety of defects in mitochondrial electron transfer enzyme activities. Complex I and Complex IV activities in skeletal muscle are almost universally decreased in mitochondrial diabetics compared with control individuals. The major physiologic abnormality in classic mitochondrial diabetes is delayed and insufficient insulin secretion in response to a glucose load. Insulin resistance is less commonly observed in these patients. The link between mitochondrial function and insulin secretion is supported by cellular studies in which introduction of inhibitors of oxidative phosphorylation or depletion of mitochondrial DNA markedly impairs glucose mediated insulin secretion from pancreatic β-cells. Evidence for mitochondrial dysfunction in the common form of type II diabetes includes excessive free radical levels in the plasma of diabetics, increased reactive oxygen species, and decreased ATP synthase activity in cybrids constructed from mitochondria of diabetic patients, and maternal inheritance of the disease. By using the occurrence of diabetes in rare mitochondrial syndromes as an example, evidence supporting a relationship between mitochondrial dysfunction and the common form of type II diabetes is discussed. Mitochondrial function may represent a novel area for the development of therapeutic and diagnostic strategies for type II diabetes mellitus. Drug Dev. Res. 46:67–79, 1999. © 1999 Wiley-Liss, Inc.
Correlation imaging for multiscan MRI with parallel data acquisition (2012)

A new approach to high-speed magnetic resonance imaging (MRI) that uses all the data acquired in a multiscan imaging session is presented. This approach accelerates MRI data acquisition by statistically estimating correlation functions from images with different contrast and/or resolution. In multiscan MRI with parallel data acquisition, the estimation of correlation functions is dynamically improved as imaging proceeds. This allows imaging acceleration factors to be increased in subsequent scans, thereby reducing the total time of a multiscan MRI protocol. Furthermore, the correlation function estimates bring information about both coil sensitivity and anatomical structure into image reconstruction, thereby offering the ability to speed up MRI beyond the parallel imaging acceleration limit posed by a coil array alone. In this study, the feasibility of correlation imaging is demonstrated experimentally using brain and spine imaging protocols. The ability of correlation imaging to achieve an aggregate acceleration factor in excess of the number of coil elements in the phase encoding direction is also demonstrated.
Eye Movement Control in the Argus II Retinal-Prosthesis Enables Reduced Head Movement and Better Localization Precision (2018)

Integrating an eye tracker into the Argus II is feasible, reduces head movements in a seated localization task, and improves pointing precision.
Pathogenicity of modified bat influenza virus with different M genes and its reassortment potential with swine influenza A virus (2017)

In our previous studies, the reassortant virus containing only the PR8 H1N1 matrix (M) gene in the background of the modified bat influenza Bat09 : mH1mN1 virus could be generated. However, whether M genes from other origins can be rescued in the background of the Bat09 : mH1mN1 virus and whether the resulting novel reassortant virus is virulent remain unknown. Herein, two reassortant viruses were generated in the background of the Bat09 : mH1mN1 virus containing either a North American or a Eurasian swine influenza virus M gene. These two reassortant viruses and the reassortant virus with PR8 M as well as the control Bat09 : mH1mN1 virus replicated efficiently in cultured cells, while the reassortant virus with PR8 M grew to a higher titre than the other three viruses in tested cells. Mouse studies showed that reassortant viruses with either North American or Eurasian swine influenza virus M gene did not enhance virulence, whereas the reassortant virus with PR8 M gene displayed higher pathogenicity when compared to the Bat09 : mH1mN1 virus. This is most likely due to the fact that the PR8 H1N1 virus is a mouse-adapted virus. Furthermore, reassortment potential between the Bat09 : mH1mN1 virus and an H3N2 swine influenza virus (A/swine/Texas/4199-2/1998) was investigated using co-infection of Madin-Darby canine kidney cells, but no reassortant viruses were detected. Taken together, our results indicate that the modified bat influenza virus is most likely incapable of reassortment with influenza A viruses with in vitro co-infection experiments, although reassortant viruses with different M genes can be generated by reverse genetics.
Analysis and construction of multilayer composite membranes for the separation of gas mixtures (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis and construction of multilayer composite membranes for the separation of gas mixturesKevin A. Lundy and Israel CabassoCite this: Ind. Eng. Chem. Res. 1989, 28, 6, 742–756Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/ie00090a016https://doi.org/10.1021/ie00090a016research-articleACS PublicationsRequest reuse permissionsArticle Views446Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Crystalline silicon tilting mirrors for optical cross-connect switches (2003)

This paper discusses a two-piece approach for fabricating two-dimensional (2-D) arrays of tilting MEMS mirrors with application in very-large optical cross-connect switches. In the new process, a two-sided etching of silicon-on-insulator (SOI) wafers is used to create crystalline mirrors on a first wafer that is later aligned and bonded to a separate wafer containing the activation electrodes, traces, and bond pads. The approach allows a very close spacing of mirror elements and a very simple design for the mechanical structures, and also greatly simplifies wire routing.
Design of a birdcage array for lower extremity angiography (2007)

Birdcage coils were demonstrated to be valuable for lower extremity imaging due to their homogenous sensitivity, good SNR, and cylindrical geometry. Coupling was controlled using shared capacitors that allowed a single birdcage to encompass each leg individually, providing a novel approach to signal reception for peripheral imaging.
A Method for Improving Speed Control Characteristics at Very Low Speed Region by The Least Order Disturbance Observer. (1994)

In the speed control system of motors using the low resolution rotary encoder, the period of the encoder pulses becomes longer than that of the speed control at the very low speed region. It gets impossible to obtain the accurate speed information in the period of the speed control.So we suggest an easy speed estimating method at the very low speed region using the least order disturbance observer that has been used widely. And we investigate an estimating method of the motor inertia that especially affects the speed estimation.This paper shows these principle of the method, the simulation result and the experimental one. It makes it clear that the characteristics of the speed control at the very low speed region is improved by using the least order disturbance observer.
Optical communications using orbital angular momentum beams (2015)

Orbital angular momentum (OAM), which describes the “phase twist” (helical phase pattern) of light beams, has recently gained interest due to its potential applications in many diverse areas. Particularly promising is the use of OAM for optical communications since: (i) coaxially propagating OAM beams with different azimuthal OAM states are mutually orthogonal, (ii) inter-beam crosstalk can be minimized, and (iii) the beams can be efficiently multiplexed and demultiplexed. As a result, multiple OAM states could be used as different carriers for multiplexing and transmitting multiple data streams, thereby potentially increasing the system capacity. In this paper, we review recent progress in OAM beam generation/detection, multiplexing/demultiplexing, and its potential applications in different scenarios including free-space optical communications, fiber-optic communications, and RF communications. Technical challenges and perspectives of OAM beams are also discussed.
Regions of Mycoplasma pneumoniae cytadhesin P1 structural gene exist as multiple copies (1988)

The Mycoplasma pneumoniae cytadhesin P1 structural gene with flanking regions was labeled by nick translation and used as a probe to analyze gene copy number in M. pneumoniae. Multiple bands of genomic DNA were hybridized by the probe. To establish what part of the P1 gene existed as multiple copies, the P1 gene and regions adjacent to the 3' and 5' ends were divided with restriction enzymes into 14 segments ranging in size from 174 to 651 base pairs. These pieces were purified on agarose gels, subcloned into pUC19, purified, labeled by nick translation, and used to probe the entire M. pneumoniae genome. Several regions near the middle and carboxy end of the P1 structural gene hybridized to single copies. The remaining P1 subclones hybridized to multiple bands under stringent hybridization conditions, indicating extensive homology with other parts of the M. pneumoniae genome. The single- versus multiple-copy nature of P1 structural gene domains is discussed.
Phthalonitrile‐glass fabric composites (1997)

Abstract Phthalonitrile polymers, under development at the Naval Research Laboratory, offer promise as high temperature, high performance composite matrix materials. A fully cured resin shows outstanding thermal stability with no evidence of a glass transition temperature or T g up to 450°C, good mechanical properties, and is easily processed into void‐free components. Phthalonitrile/glass fabric composite panels have been successfully fabricated by conventional consolidation of prepregged glass and by a more recently developed simplified process, resin infusion molding. Both processes can be used to produce panels with comparable mechanical properties. More important, flammability performance of these composites, evaluated in terms of specific optical density, combustion gases, heat release, and ignitability, excels over other state‐of‐the‐art polymer/glass composites. This finding is significant given that overcoming flammability obstacles has been the main limiting factor for use of composites in marine applications.
Improving sensitivity in chiral supercritical fluid chromatography for analysis of active pharmaceutical ingredients (2007)

Despite its status as the preferred method for routine enantiopurity analysis in pharmaceutical research, supercritical fluid chromatography (SFC) has historically been unsuited for the accurate and precise measurements required for release testing of active pharmaceutical ingredients (APIs) under current good manufacturing processes (cGMPs). Insufficient signal to noise, as compared to HPLC, has heretofore been the major limitation of the chiral SFC approach. We herein describe an investigation into the fundamental limitations and sources of noise in the SFC approach, identifying thermal, electronic, and mechanical sources of noise within the flow cell as key parameters contributing to reduced sensitivity. A variety of instrument modifications are explored, ultimately leading to the development of a new and improved flow cell and other instrument modifications that allow suitable sensitivity and accuracy to carry out GMP release testing for enantiopurity analysis using SFC.