gebhart/patrepeval huggingface dataset:
StethoVest: A simultaneous multichannel wearable system for cardiac acoustic mapping (2018)

Cardiac acoustic mapping remains a highly unexplored area, likely due in part to a decline in research into heart auscultation over the past several decades. However, because the stethoscope remains an integral part of clinical care, novel approaches to improve the accuracy and scope of auscultation are now being explored. The current work introduces an innovative design for heart acoustic mapping based on a microphone array embedded in a wearable vest. The system incorporates a customized design of a front-end readout channel with discrete components paired with analog to digital converter DAQ modules. The main scope is to provide simultaneous recordings of heart sounds to generate spatiotemporal images. This noninvasive and time efficient technique will assist in the exploration of normal and pathological heart activity propagation patterns, providing new knowledge to the current understanding of the cardiac acousteome.
Time to Endoscopy in Patients with Colorectal Cancer: Analysis of Wait-Times (2016)

Objective. The Canadian Association of Gastroenterology Wait Time Consensus Group recommends that patients with symptoms associated with colorectal cancer (CRC) should have an endoscopic examination within 2 months. However, in a recent survey of Canadian gastroenterologists, wait-times for endoscopy were considerably longer than the current guidelines recommend. The purpose of this study was to evaluate wait-times for colonoscopy in patients who were subsequently found to have CRC through the Division of Gastroenterology at St. Paul's Hospital (SPH). Methods. This study was a retrospective chart review of outpatients seen for consultation and endoscopy ultimately diagnosed with CRC. Subjects were identified through the SPH pathology database for the inclusion period 2010 through 2013. Data collected included wait-times, subject characteristics, cancer characteristics, and outcomes. Results. 246 subjects met inclusion criteria for this study. The mean wait-time from primary care referral to first office visit was 63 days; the mean wait-time to first endoscopy was 94 days. Patients with symptoms waited a mean of 86 days to first endoscopy, considerably longer than the national recommended guideline of 60 days. There was no apparent effect of length of wait-time on node positivity or presence of distant metastases at the time of diagnosis. Conclusion. Wait-times for outpatient consultation and endoscopic evaluation at the St. Paul's Hospital Division of Gastroenterology exceed current guidelines.
Microscopical Characterization of Degraded Air Electrode of SOFC (1995)

Degradation of air electrode was examined by AC impedance method for 10000 hours. Microscopical characterization of the tested electrode was analyzed by SEM. It is found that interfacial resistance had increased remarkably after about 3000 hours. The degraded electrode showed decreases of porosity, average pore area, and the length of the triple phase boundaries.
The Role of c-Jun N-Terminal Kinase, p38, and Extracellular Signal-Regulated Kinase in Insulin-Induced Thr69 and Thr71 Phosphorylation of Activating Transcription Factor 2 (2006)

The stimulation of cells with physiological concentrations of insulin induces a variety of responses, e.g. an increase in glucose uptake, induction of glycogen and protein synthesis, and gene expression. One of the determinants regulating insulin-mediated gene expression may be activating transcription factor 2 (ATF2). Insulin activates ATF2 by phosphorylation of Thr69 and Thr71 via a two-step mechanism, in which ATF2-Thr71 phosphorylation precedes the induction of ATF2-Thr69+71 phosphorylation by several minutes. We previously found that in c-Jun N-terminal kinase (JNK)-/- fibroblasts, cooperation of the ERK1/2 and p38 pathways is required for two-step ATF2-Thr69+71 phosphorylation in response to growth factors. Because JNK is also capable of phosphorylating ATF2, we assessed the involvement of JNK, ERK1/2 and p38 in the insulin-induced two-step ATF2 phosphorylation in JNK-expressing A14 fibroblasts and 3T3L1-adipocytes. The induction of ATF2-Thr71 phosphorylation was sensitive to MAPK kinase (MEK) 1/2-inhibition with U0126, and this phosphorylation coincided with nuclear translocation of phosphorylated ERK1/2. Use of the JNK inhibitor SP600125 or expression of dominant-negative JNK-activator SAPK kinase (SEK1) prevented the induction of ATF2-Thr69+71, but not ATF2-Thr71 phosphorylation by insulin. ATF2-dependent transcription was also sensitive to SP-treatment. Abrogation of p38 activation with SB203580 or expression of dominant-negative MKK6 had no inhibitory effect on these events. In agreement with this, the onset of ATF2-Thr69+71 phosphorylation coincided with the nuclear translocation of phosphorylated JNK. Finally, in vitro kinase assays using nuclear extracts indicated that ERK1/2 preceded JNK translocation. We conclude that sequential activation and nuclear appearance of ERK1/2 and JNK, rather than p38, underlies the two-step insulin-induced ATF2 phosphorylation in JNK-expressing cells.
Passive Damping Optimization of the Integrated-Magnetics-Based Differential-Mode Ćuk Rectifier (2020)

Interaction of the ac-link capacitor with ac- and dc-side inductors in the Ćuk converter topology introduces resonant frequency oscillations that affect the dynamic response and performance of the converter. To mitigate these effects, in this letter, a simple passive damping-based solution is employed, which is optimized both from control perspective and power loss for an integrated-magnetics-based differential-mode Ćuk rectifier. An experimental prototype is developed to validate the effect of no damping versus optimized damping and its effects on the rectifier performance parameters are provided.
Photothermal detection of laser‐induced damage in single intact cells (2003)

The Laser load test (LLT) was suggested for real-time detection of damage, damage threshold measurement, and investigation of intact single cells.
System Performance Analysis With Availability Constraints. (1992)

ET that was used as a supportive therapy for traditional treatments resulted in statistically significant improvements in the occupational performance, mood, quality of life, gait, and balance of the participants. Data from the stabilometric platform did not show significant changes.
Parallel processing RAM chip with 256 Mb DRAM and quad processors (2002)

Parallel processing RAM (PPRAM) is an architectural framework for merged memory/logic application-specific standard products (ASSPs). It integrates onto a single chip (1) a large amount of DRAM and/or SRAM and/or flash EEPROM and/or FRAM (2) zero or more general-purpose processors and/or application-specific processors and/or FPGA, etc.; (3) a network interface based on a common communication protocol. Many different implementations of PPRAM are possible. All provide a common network interface (called PPRAM-link). System designers will be able to construct computer systems of any size, of any functionality, and of any performance, just by choosing the required PPRAM chips from those various PPRAM implementations and by interconnecting them through the PPRAM-link network.
An Efficient TLM/T Modeling and Simulation Environment Based on Conservative Parallel Discrete Event Principles (2006)

The paper presents an innovative simulation scheme to speed-up simulations of multi-clusters multi-processors SoCs at the TLM/T (transaction level model with time) abstraction level. The hardware components of the SoC architecture are written in standard SystemC. The goal is to describe the dynamic behavior of a given software application running on a given hardware architecture (including the dynamic contention in the interconnect and the cache effects), in order to provide the system designer with the same reliable timing information as a cycle accurate simulation, with a simulation speed similar to a TLM simulation. The key idea is to apply parallel discrete event simulation (PDES) techniques to a collection of communicating SystemC SC-THREAD. Experimental results show a simulation speedup of a factor up to 50 versus a BCA simulation (bus cycle accurate), for a timing error lower than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup>
FSC-Q: a CryoEM map-to-atomic model quality validation based on the local Fourier shell correlation (2021)

In recent years, advances in cryoEM have dramatically increased the resolution of reconstructions and, with it, the number of solved atomic models. It is widely accepted that the quality of cryoEM maps varies locally; therefore, the evaluation of the maps-derived structural models must be done locally as well. In this article, a method for the local analysis of the map-to-model fit is presented. The algorithm uses a comparison of two local resolution maps. The first is the local FSC (Fourier shell correlation) between the full map and the model, while the second is calculated between the half maps normally used in typical single particle analysis workflows. We call the quality measure "FSC-Q", and it is a quantitative estimation of how much of the model is supported by the signal content of the map. Furthermore, we show that FSC-Q may be helpful to detect overfitting. It can be used to complement other methods, such as the Q-score method that estimates the resolvability of atoms.
The Design and Construction of Secure Landfill for the Storage of Hazardous Wastes at New Plymouth (1988)

In 1984 Beca Carter Hollings and Ferner Ltd (BCHF) were commissioned by Ivon Watkins-Dow Ltd (IWD) to report on the status of two existing waste chemical landfills which were found to be leaking their contents onto an adjacent foreshore. The report was also to investigate alternative solutions to the problem so that remedial action could be taken. As a result of the conclusions reached in this report BCHF were engaged to carry out a detailed investigation into the establishment of a new, secure landfill facility, and to undertake the design and construction supervision of the landfill. This paper backgrounds the investigation work undertaken and the options considered. It details the design finally adopted and describes the construction sequence from the initial excavation to the placement of the final permanent cap following the successful transfer of the contaminated material.
Extracellular signal-regulated protein kinase signaling is uncoupled from initial differentiation of central nervous system stem cells to neurons. (2002)

Knowledge about signaling pathways in response to external signals is needed to understand the regulation of stem cell proliferation and differentiation toward particular cell fates. The Ras/extracellular signal-regulated kinase (ERK) pathway has been suggested to play an essential role in neuronal differentiation. We have examined ERK signaling in the transition from multipotent stem cell to post-mitotic progeny using primary stem cells from the rat embryonic cortex. Fibroblast growth factor-2 (FGF-2) is a stem cell mitogen, whereas platelet-derived growth factor AA (PDGF-AA) expands a pool of committed neuronal precursors from stem cells. When comparing ERK activation by these growth factors, we found that FGF-2 stimulates high and PDGF-AA lower levels of ERK phosphorylation in stem cells. Differentiation was monitored as down-regulation of the bHLH transcription factor mammalian achaete-scute homologue-1 (MASH1). Even in the absence of active ERK, MASH1 became down-regulated and microtubule-associated protein 2-positive cells could form. Thus, ERK activation seems dispensable for the earliest steps of CNS stem cell differentiation.
DEVELOPMENT AND EVALUATION OF A SHORT STAY PROGRAM FOR TOTAL HIP REPLACEMENT (2006)

Introduction Total hip replacement is the commonest arthroplasty procedure performed in the UK. The in-patient stay has gradually reduced and patients now typically spend five to seven days in hospital. We have developed a new multidisciplinary protocol for patients undergoing total hip replacement in order to facilitate early discharge. The aims of this study were to prospectively assess whether this new protocol could be safely applied to patients undergoing total hip replacement and whether it reduced length of stay. Methods The protocol involved a pre-operative program of education and physiotherapy, a modified anaesthetic regime, a minimally invasive surgical approach and a portable local anaesthetic pump infusion for post operative pain control. Strict inclusion and exclusion criteria were developed based on age, medical status and social circumstances. Patients were mobilised on the day of their operation and discharged to an outreach team support network. Independent evaluation was performed using the Oxford Hip Questionnaire, the Merle dAubigne clinical rating system and Visual Analogue Pain Scores. Results Twenty-five patients underwent total hip replacement using the new protocol. All patients were discharged home within 48 hours of surgery. There were two unplanned reattendances neither of which required readmission. The mean pain score on discharge was 3/10. The Oxford Hip Questionnaire and Merle dAubigne scores were comparable to patients who underwent surgery prior to the introduction of the new protocol. Discussion Minimising in-patient stay for total hip replacement benefits the patient by reducing exposure to nosocomial infection and expediting the return to a normal environment for rehabilitation. It may also help to improve efficiency and alleviate pressure on an overburdened health service. This new protocol allows patients undergoing total hip replacement to be discharged within 48 hours of undergoing surgery without compromising safety or quality of care.
Crossbow (2009)

This paper describes a new architecture which addresses Quality of Service (QoS) by creating unique flows for applications, services, or subnets. A flow is a dedicated and independent path from the NIC hardware to the socket layer in which the QoS layer is integrated into the protocol stack instead of being implemented as a separate layer. Each flow has dedicated hardware and software resources allowing applications to meet their specified quality of service within the host.The architecture efficiently copes with Distributed Denial of Service (DDoS) attacks by creating zero or limited band-width flows for the attacking traffic. The unwanted packets can be dropped by the NIC hardware itself at no cost.A collection of flows on more than one host can be assigned the same Differentiated Services Code Point (DSCP) label which forms a path dedicated to a service across the enterprise network and enables end-to-end QoS within the data center.
An efficient BIST method for non-traditional faults of embedded memory arrays (2003)

In this work, a built-in self-testing (BIST) method is proposed to detect non-traditional faults of embedded memory arrays for a system-on-chip design. The non-traditional faults include single-cell read-sensitive faults and read coupling faults. The BIST method can efficiently deal with embedded memory arrays spatially distributed on the entire SoC chip. The concept of redundant read-write operations is applied to detect all embedded memory arrays with different sizes simultaneously. The redundant operations do not affect fault coverage of the non-traditional faults. The method has the advantages of low hardware overhead, short test time, and high fault coverage for non-traditional defects.
Controlled synthesis of CdTe nanocrystals for high performanced Schottky thin film solar cells (2012)

We report the synthesis of CdTe semiconductor nanocrystals (NCs) with multi-armed, rod and tetrapod shapes, developed by a facile solution process using a cadmium carboxylate as the precursor at moderate temperatures of 220–300 °C. It was found that the size and morphology of the CdTe NCs were related to synthesis parameters such as the reaction temperature, carboxyl chain length and carboxylic acid. Based on these CdTe NCs, photovoltaic cells (PVC) in simple Schottky diode configuration of ITO/CdTe/Al were fabricated. The performances of the CdTe NCs solar cells were found to strongly rely on the morphology and surface ligand of the CdTe NCs. The best device could show a power conversion efficiency (PCE) of 5.15% under AM 1.5G illumination at 100 mW cm−2, which is the highest efficiency of a CdTe NC-based Schottky solar cell reported to date. Notably, in comparison to the ITO/CdTe/LiF/Al device, the device configuration of ITO/CdTe/Al showed higher efficiency and better air-stability.
Production of an extensive sunflower protein hydrolysate by sequential hydrolysis with endo- and exo-proteases. (1999)

A high quality protein isolate has been obtained from defatted sunflower meal by alkaline extraction and isoelectric precipitation. Protein content was increased from 31.2 % in the defatted flour to 97 % in the protein isolate. The percentages of fiber, soluble sugars, polyphenols and residual lipids in the protein isolate were reduced to more than 90 % with respect to the defatted meal. The protein isolate was used as starting material for the generation of an extensive enzymatic protein hydrolysate. The hydrolysis was carried out in a pH stat using sequentially an endo-protease (Alcalase) and an exo-protease (Flavourzyme). The protein hydrolysate, with a degree of hydrolysis of 50.7 %, was white and non bitter.
Compression domain volume rendering (2004)

A survey of graphics developers on the issue of texture mapping hardware for volume rendering would most likely find that the vast majority of them view limited texture memory as one of the most serious drawbacks of an otherwise fine technology. In this paper, we propose a compression scheme for static and time-varying volumetric data sets based on vector quantization that allows us to circumvent this limitation. We describe a hierarchical quantization scheme that is based on a multiresolution covariance analysis of the original field. This allows for the efficient encoding of large-scale data sets, yet providing a mechanism to exploit temporal coherence in non-stationary fields. We show, that decoding and rendering the compressed data stream can be done on the graphics chip using programmable hardware. In this way, data transfer between the CPU and the graphics processing unit (GPU) can be minimized thus enabling flexible and memory efficient real-time rendering options. We demonstrate the effectiveness of our approach by demonstrating interactive renditions of Gigabyte data sets at reasonable fidelity on commodity graphics hardware.
Recovery of Neurological Functions in Non-Human Primate Model of Parkinson's Disease by Transplantation of Encapsulated Neonatal Porcine Choroid Plexus Cells (2013)

Parkinson's disease (PD) is a neurodegenerative disease that is primarily characterized by degeneration of dopaminergic (DA) neurons in the substantia nigra (SN) and a loss of their fibre projections in the striatum. We utilized the neonatal porcine choroid plexus (CP), an organ that secretes cerebrospinal fluid containing various types of neurotrophic and neuroprotective factors, to ameliorate the Parkinsonian symptoms in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-treated rhesus monkeys without requiring immunosuppression. We demonstrate that transplanted encapsulated CP clusters (eCPs) significantly improved neurological functions in MPTP-treated monkeys during the course of six months after transplantation (p < 0.001) when compared with monkeys implanted with empty capsules or subjected to sham surgery. The improvement in neurological scores was accompanied by a corresponding improvement in apomorphine-induced circling behaviour (p < 0.001) as well as increased tyrosine hydroxylase (TH) staining in the striatum. Our results suggest that eCPs are a promising cell therapeutic agent to treat Parkinson's disease.
Fine fragments in high‐velocity impact experiments (1985)

Ejection angle dependences of size and kinetic energy of high‐velocity fine fragments ejected by high‐velocity impact into basalt targets were studied by exposing secondary targets to the ejecta. According to the properties of the fine ejecta the ejection angles were divided into four regions: outer region (region I, 10° < θ < 40°), outer belt region (region II, 40° < θ < 45°), inner belt region (region III, 45° < θ < 55°) and inner region (region IV, θ > 55°), where θ was measured from the target surface. The size distributions of the fine ejecta were expressed by power law functions with power indices of about −3.5, except for region IV (about −3) in the size range of 1–70 μm. The secondary microcraters smaller than 100 μm in diameter were most abundant in region II, and their diameter distributions were also expressed by power law functions with power indices of about −3. Comminution energy, which was estimated from surface energy of the fine ejecta, was about 10% of the impact energy, and kinetic energy of the high‐velocity fine ejecta, which was estimated from formation energy of the secondary microcraters, was about 40% of the impact energy.
Noradrenergic Regulation of Cholinergic Differentiation (1994)

When the sympathetic nerves that innervate rat sweat glands reach their targets, they are induced to switch from using norepinephrine as their neurotransmitter to acetylcholine. Catecholamines (such as norepinephrine) released by nerves growing to the sweat gland induce this phenotypic conversion by stimulating production of a cholinergic differentiation factor [sweat gland factor (SGF)] by gland cells. Here, culture of gland cells with sympathetic, but not sensory, neurons induced SGF production. Blockage of alpha 1- or beta-adrenergic receptors prevented acquisition of the cholinergic phenotype in sympathetic neurons co-cultured with sweat glands, and sweat glands from sympathectomized animals lacked SGF. Thus, reciprocal instructive interactions, mediated in part by small molecule neurotransmitters, direct the development of this synapse.
Beat the MTurkers: Automatic Image Labeling from Weak 3D Supervision (2014)

Labeling large-scale datasets with very accurate object segmentations is an elaborate task that requires a high degree of quality control and a budget of tens or hundreds of thousands of dollars. Thus, developing solutions that can automatically perform the labeling given only weak supervision is key to reduce this cost. In this paper, we show how to exploit 3D information to automatically generate very accurate object segmentations given annotated 3D bounding boxes. We formulate the problem as the one of inference in a binary Markov random field which exploits appearance models, stereo and/or noisy point clouds, a repository of 3D CAD models as well as topological constraints. We demonstrate the effectiveness of our approach in the context of autonomous driving, and show that we can segment cars with the accuracy of 86% intersection-over-union, performing as well as highly recommended MTurkers!
O humor gráfico na imprensa sindical: o caso da tira “Exploração Ilimitada” (2016)

Durante a decada de 1980, a imprensa sindical se apresentou como uma das mais importantes areas de organizacao, articulacao e atuacao politicas do movimento sindical combativo. Para alem disso, a constituicao de uma nova concepcao de imprensa sindical se fez coetânea do processo de consolidacao do “novo sindicalismo” e importantes experiencias comunicativas foram desenvolvidas. Nesse contexto, a utilizacao de recursos visuais, em especial o humor grafico, se constituiu como uma das mais significativas estrategias comunicacionais no universo sindical. Esse artigo traz a luz a experiencia da tira de quadrinhos “Exploracao Ilimitada”, produzida pelo Sindicato dos Quimicos e Farmaceuticos de Sao Paulo, com circulacao no boletim Sindiluta, durante o primeiro semestre do ano de 1986.
Selegiline Treatment Facilitates Recovery After Stroke (2001)

Selegiline seems to be beneficial after a cerebral infarction. This benefit may be due to the enhancement of the recovery process.