gebhart/patrepeval huggingface dataset:
A SUMMARY OF SULPHUR-ASPHALT DESIGN TECHNOLOGY --PROCEEDINGS OF THE FIFTH INTERNATIONAL CONFERENCE ON THE STRUCTURAL DESIGN OF ASPHALT PAVEMENTS HELD DEFLT UNIVERSITY OF TECHNOLOGY, AUGUST 23-26 1982. VOL 1 AND 2. -- NETHERLANDS (1982)

Sulphur-asphalt pavement design technology has undergone extensive development in North America and abroad since the early 1970's. These pavements represent a viable alternative to conventional asphalt pavements and they offer potential economic and performance advantages. Extensive laboratory, field and analytical investigations have been conducted to verify the design technology. This paper reports on the design technology for sulphur-asphalt pavements as developed by gulf Canada limited and cooperating organizations and individuals. Several major aspects of the technology are addressed, including materials production, properties and quality assurance, structural design and economical considerations. Examples of each aspect are presented. Sulphur-asphalt mixes have been found to have a lower temperature susceptibility than conventional mixes and they therefore offer the designer increased flexibility with respect to low-temperature and permanent deformation requirements. In addition, increased fatigue life and/or thickness reductions can be achieved under certain conditions. Production, transport, placement and compaction of sulphur-asphalt mixes is done with conventional methods and equipment. It is essential to produce the sulphur-asphalt binder by preblending the components, rather than by separately introducing the components and pugmill blending them, for reasons of improved engineering properties plus quality assurance. The paper provides a summary list of some of the field trials conducted in North America, Europe and the mid East. Observations to date have verified the laboratory and theoretically based design results related to permanent deformation and low-temperature cracking, as well as the upgrading possible with low-quality aggregates. Thickness reduction and/or fatigue resistance advantages remain to be verified. Finally, the paper briefly reviews the potential economic advantages of using sulphur-asphalt. These relate to materials cost savings, conservation of materials and potential performance advantages.(a) for the covering abstract of the conference see IRRD 815640.
Mutation of a <i>mutL</i> Homolog in Hereditary Colon Cancer (1994)

Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of expressed sequence tags derived from random complementary DNA clones revealed three additional human mismatch repair genes, all related to the bacterial mutL gene. One of these genes (hMLH1) resides on chromosome 3p21, within 1 centimorgan of markers previously linked to cancer susceptibility in HNPCC kindreds. Mutations of hMLH1 that would disrupt the gene product were identified in such kindreds, demonstrating that this gene is responsible for the disease. These results suggest that defects in any of several mismatch repair genes can cause HNPCC.
Abstract 5540: Preclinical investigation of the novel histone deacetylase (HDAC) inhibitor AR-42 in the treatment of cancer-induced cachexia (2014)

Abstract Background: Cachexia occurs in more than 50% of cancer patients. Cachexia is characterized by severe loss of weight and skeletal muscle that is not reversed by nutritional support, and contributes significantly to morbidity and mortality. The development of effective therapies for cancer cachexia is clearly warranted. AR-42 is a novel class I/IIB HDAC inhibitor that was developed in our laboratories and currently in Phase I/IB trials at The Ohio State University. Here, we report the anti-cachectic activity of AR-42 in two murine models of cancer cachexia. Methods: Experiments were conducted using the colon-26 adenocarcinoma (C-26) and Lewis lung carcinoma (LLC) tumor mice models of cancer cachexia. AR-42 was administered by oral gavage at 50 mg/kg every other day starting at day 6 after tumor cell inoculation. Serum samples (n = 3) and muscle tissues (n = 8) from each group were sent for RNAseq and small RNAseq (OSU), cytokine/chemokine profiling assays [Eve Technologies, Alberta, Canada] and metabolomic analyses [Metabolon, Research Triangle Park, NC]. Results: In the C-26 model, AR-42 significantly attenuated cachexia-induced losses of skeletal muscle mass and body weight, with minimal effects on C-26 tumor growth, and prolonged survival time relative to mice treated with vehicle only or with other HDAC inhibitors (vorinostat and romidepsin). Metabolomic and gene expression analyses revealed that the effects of AR-42 were associated with its ability to maintain metabolic and gene expression profiles in skeletal muscle to levels comparable to those in muscle from tumor-free mice. Analysis of RNAseq data of relevant genes suggests that AR-42 modulates major pathways involved in muscle wasting, mitochondrial function, lipolysis, and cytoskeletal integrity. The main mechanism of action is thought to be through down-regulating FOXO1 (&gt; 5-fold) leading to suppression of MuRF1 and Atrogin-1. Additional mechanistic validation is underway and full results will be available at the meeting. AR-42-induced abrogation of cachexia and rescue of muscle weight was additionally confirmed in the LLC model. Conclusion: Our results suggest AR-42 induces unique protective effects on cancer-induced muscle wasting and lipolysis, and our findings support further evaluation of AR-42 as a potential treatment for cancer cachexia. Citation Format: Yu-Chou Tseng, Samuel Kulp, I-Lu Lai, Wei He, Ralf Bundschuh, David Frankhouser, Pearlly Yan, Denis Guttridge, Guido Marcucci, Ching-Shih Chen, Tanios Bekaii-Saab. Preclinical investigation of the novel histone deacetylase (HDAC) inhibitor AR-42 in the treatment of cancer-induced cachexia. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5540. doi:10.1158/1538-7445.AM2014-5540
Use of flavonoids to increase the bioavailability of hesperetin. European patent application (2010)

Date of filing: 31.03.09 Application no. 09156910.3-2123 Also filed under international application number PCT/EP2010/054215 (filed 30.03.10) Publication number WO/2010/112510 (07.10.2010)
Topical Compounded Analgesic Treatment in Neuropathic Pain: 8 years of Experience (2017)

In our tertiary referral centre, the Institute for Neuropathic Pain, we have treated many patients suffering from localized peripheral neuropathic pain since 2009. We have developed, together with a compounding pharmacist, a base cream as a topical formulation which has enabled us to compound creams based on amongst others amitriptyline, ketamine, clonidine, baclofen, and phenytoin. We have found that many patients profit from such topical formulations and we will describe our experiences using such creams over the last 8 years in this paper, since we first started exploring such topical treatments. We have analysed the efficacy and safety of these topicals, and based on literature, our own online data pool and the patients who had let us know that they benefited from the creams, found sufficient analgesia and positive effects impaired sleep, while the tolerability was excellent. Patients suffering from localized peripheral neuropathic pain, as in diabetic neuropathy, chronic idiopathic axonal polyneuropathy, chemotherapy induced polyneuropathy and small fiber neuropathy, as well as in complex regional pain syndrome, seem especially responsive to such topical approach. Meanwhile, more than 800 Dutch medical doctors have been prescribing one or more of our compounded creams, and patients and medical doctors from abroad frequently contact us to explore the therapeutic options for their patients based on these creams.
Integrated Navigation System with a Dual-Antenna GNSS Receiver and a MEMS IMU Embedded into One of the Two Antennas (2019)

The integrated navigation system for determining the position, velocity and attitude of a vehicle is described. This system consists of a dual-antenna GNSS receiver and a microelectromechanical inertial measurement unit embedded into one of two antennas. The dual-antenna GNSS receiver measures only two of the three attitude angles, which are calculated from the fractional parts of the total phases of the carrier signal without resolution of integer ambiguities. Inertial measurements are performed by the inertial measurement unit located inside one of the antennas near its phase center. The measurements are transmitted to the GNSS receiver via the radio frequency cable, together with the GNSS signal received by that antenna. Inertial measurements are combined with the GNSS measurements of the position, velocity, and two attitude angles using the Extended Kalman Filter according to the “loose coupling” approach. Operation principles of individual components of the integrated system are described. The results of the experiments with this system-carried out on various types of vehicles and under various environment conditions are presented.
Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination. (1993)

We have characterized two transcripts from the male-determining her-1 locus in Caenorhabditis elegans. The larger transcript, which appears more important for male development, is predicted to encode a novel 175-amino-acid, cysteine-rich polypeptide with an apparent amino-terminal signal sequence and potential cleavage and glycosylation sites. Expression of a full-length cDNA construct for the larger transcript driven by a body-wall-myosin promoter causes extensive masculinization of all sexually dimorphic tissues in XX (normally hermaphrodite) animals. This activity is dependent on the presence of the her-1 signal sequence or a substitute synthetic signal sequence in the encoded polypeptide. These results suggest that a secreted product of the her-1 gene dictates male development.
Lensless On-Chip Fluorescent Imaging Over an Ultra Wide Field-of-View (2010)

We introduce a lensless high-throughput fluorescent detection modality that can simultaneously image micro-objects and labeled cells over an ultra-wide field-of-view (FOV) of ∼8cm2 without the use of any lenses, thin-film filters and mechanical scanners. This lensfree platform utilizes total-internal-reflection (TIR) to block the excitation light, and an inexpensive absorption filter to remove the weakly scattered light that does not obey TIR. The emitted fluorescent light from the objects is then detected on the same chip without the use of any lenses. A digital deconvolution algorithm is used to resolve overlapping fluorescent spots, enabling a resolution of ∼40–50 μm over the entire field-of-view. Such an ultra wide field-of-view lensfree fluorescent imaging modality might be very valuable for high-throughput screening applications as well as quantification of rare cells such as circulating tumor cells using ultra-large microfluidic devices.
The Role of Co-Solvents and Co-Surfactants in Making Chemical Floods Robust (2010)

Abstract The ability to select low-cost, high-performance surfactants for a wide range of crude oils and reservoir conditions has improved dramatically. There are thousands of possible combinations of chemicals and components (including differing salinities, hardness, and oil concentrations) that could be tested on each crude oil. Each chemical combination requires many observations at reservoir temperature for proper evaluation. Therefore it would take too long, be too expensive, and in many cases not even be feasible to test all combinations. In practice we use our scientific understanding of surfactant/co-surfactant/co-solvent characteristics to match a chemical formulation to the properties of a crude oil and formation brine salinity at reservoir temperature. Typically the surfactant is mixed with other chemicals such as polymer in brine and injected at optimum salinity (the ASP slug). It is important that the ASP slug be a clear, stable solution since precipitation or phase separation will interfere with surfactant and polymer transport deep into the reservoir. Co-solvents and/or co-surfactants are often needed to make the primary surfactant sufficiently soluble. Core floods are presented that show the oil recovery is significantly increased by simply adding a small concentration of co-surfactant to make the ASP slug clear. In such cases, the use co-solvent/ co-surfactant is economically beneficial in terms of higher oil recovery because of the improved surfactant performance, lower surfactant retention and improved effectiveness of the polymer for mobility control.
Effects of Microstructure Variations on Macroscopic Terahertz Metafilm Properties (2007)

The properties of planar, single-layer metamaterials, or metafilms, are studied by varying the structural components of the split-ring resonators used to comprise the overall medium. Measurements and simulations reveal how minor design variations in split-ring resonator structures can result in significant changes in the macroscopic properties of the metafilm. A transmission-line/circuit model is also used to clarify some of the behavior and design limitations of the metafilms. Though our results are illustrated in the terahertz frequency range, the work has broader implications, particularly with respect to filtering, modulation, and switching devices.
Assessment of Loosely-bound and Firmly-bound Fluoride Uptake by Tooth Enamel from Topically Applied Fluoride Treatments (1990)

The amounts of loosely-bound fluoride (F) deposited on human enamel by two topical F treatments were measured with use of a constant-composition F washing method. Enamel biopsies conducted before treatment and after the washing were used for determination of the firmly-bound F uptake. The results showed that (1) the washing system did not remove F from untreated enamel surface, (2) a four-minute application of an acidulated phosphate fluoride (APF) gel deposited 27.2 (2.4) (mean, S.E.) micrograms of loosely-bound F per cm2 of enamel surface and 186 (111) ppm of firmly-bound F in the outer 10 microns of enamel, and (3) a four-minute application of a pH-2.1 dicalcium phosphate dihydrate (DCPD)-forming solution followed by APF produced 44.9 (3.1) micrograms/cm2 of loosely-bound F and 1280 (354) ppm of firmly-bound F in the outer 10 microns of enamel. The results showed that the DCPD pre-treatment effectively enhanced the enamel reactivity with F, so that the DCPD-APF treated enamel acquired greater amounts of both loosely-bound F and firmly-bound F than did samples treated with APF alone.
Hardware-Software Co-Synthesis of Low Power Real-Time Distributed Embedded Systems with Dynamically Reconfigurable FPGAs (2002)

In this paper, we present a multi-objective hardware-software co-synthesis system for multi-rate, real-time, low power distributed embedded systems consisting of dynamically reconfigurable FPGAs, processors, and other system resources. We use an evolutionary algorithm based framework for automatically determining the quantity and type of different system resources, and then assigning tasks to different processing elements (PEs) and task communications to communication links. For FPGAs, we propose a two-dimensional, multi-rate cyclic scheduling algorithm, which determines task priorities based on real-time constraints and reconfiguration overhead information, and then schedules tasks based on the resource utilization and reconfiguration condition in both space and time. The FPGA scheduler is integrated in a list-based system scheduler. To the best of our knowledge, this is the first multi-objective co-synthesis system, which uses dynamically reconfigurable devices to synthesize a distributed embedded system, to target simultaneous optimization of system price and power. Experimental results indicate that our method can reduce schedule length by an average of 41.0% and reconfiguration power by an average of 46.0% compared to the previous method. It also yields multiple system architectures which trade off system price and power under real-time constraints.
CD8 <sup>+</sup> Cell Lines Isolated from HIV-1–Infected Children Have Potent Soluble HIV-1 Inhibitory Activity That Differs from β-Chemokines (2000)

CD8+ cells from human immunodeficiency virus type 1 (HIV-1) infected individuals have been shown to suppress HIV-1 replication both through a major histocompatibility complex (MHC)-restricted cytolytic pathway as well as through a noncytolytic pathway mediated through soluble factors. To characterize this soluble activity and its potential role in disease progression further, we studied the HIV-1 inhibition by supernatants derived from herpesvirus saimiri-transformed CD8+ cells isolated from infected children. Three of the six CD8+ cell lines derived had a phenotype consistent with an unusual natural killer (NK) cells phenotype with low CD3, high CD56, and low CD16. Supernatants from some of the cell lines derived from children with rapid progression as well as long-term nonprogressors exhibited broad HIV-1-inhibitory activity in primary CD4+ cells as well as in primary macrophages. In contrast to a cocktail of beta-chemokines, the supernatants inhibited T-tropic as well as M-tropic viruses, efficiently inhibited infection in primary macrophages, and inhibited HIV-1 activation in the chronically infected U1 cell line. The HIV-1-inhibitory activity was heat stable and active over a broad pH range. Fractionation of the supernatant by size and ion exchange chromatography demonstrated activity in the complete absence of RANTES as well as interferons-alpha, beta, and gamma and in a size range of less than 10 kD and greater than 3 kD. CD8+ cell supernatants contain additional unidentified factors that have anti-HIV activity to account for this broad phenomenon.
High-throughput screening for texturing Lactococcus strains (2019)

ABSTRACT In the food industry, lactic acid bacteria (LAB) are used in dairy fermentations, extending the shelf life by lowering the pH and also affecting taste and texture of the fermented milk. The texture of fermented milk is an important quality parameter, affecting consumer acceptance. Finding LAB providing desired texture of a product is time consuming and laborious when using standard methods for measuring texture, e.g. rheology measurements. Screening of 986 Lactococcus lactis strains resulted in few strains with the ability to enhance texture, demonstrating the necessity of implementation of high-throughput screening methods. A high-throughput screening assay was developed, combining small-scale 96-well microtiter plates and pressure measurements during liquid handling, e.g. aspiration, to find strains that give good texture in fermented milk. Only about 1% of the strains were found to enhance milk texture. Two of the texturing strains belong to L. lactis subsp. lactis, which are the first texturing strains from this subsp. reported. Mining for eps gene clusters responsible for exocellular polysaccharide production was performed, as polysaccharide production can contribute positively to fermented milk texture. Comparative genomics approach revealed four types of texturing L. lactis strains with diverse eps gene clusters.
Linear and nonlinear optical characterization of self-assembled, large-area gold nanosphere metasurfaces with sub-nanometer gaps (2016)

We created centimeter-scale area metasurfaces consisting of a quasi-hexagonally close packed monolayer of gold nanospheres capped with alkanethiol ligands on glass substrates using a directed self-assembly approach. We experimentally characterized the morphology and the linear and nonlinear optical properties of metasurfaces. We show these metasurfaces, with interparticle gaps of 0.6 nm, are modeled well using a classical (without charge transfer) description. We find a large dispersion of linear refractive index, ranging from values less than vacuum, 0.87 at 600 nm, to Germanium-like values of 4.1 at 880 nm, determined using spectroscopic ellipsometry. Nonlinear optical characterization was carried out using femtosecond Z-scan and we observe saturation behavior of the nonlinear absorption (NLA) and nonlinear refraction (NLR). We find a negative NLR from these metasurfaces two orders of magnitude larger (n<sub>2,sat</sub> = -7.94x10<sup>-9</sup> cm<sup>2</sup>/W at I<sub>sat,n2</sub> = 0.43 GW/cm<sup>2</sup>) than previous reports on gold nanostructures at similar femtosecond time scales. We also find the magnitude of the NLA comparable to the largest values reported (β<sub>2,sat</sub> = -0.90x10<sup>5</sup> cm/GW at I<sub>sat,β2</sub> = 0.34 GW/cm<sup>2</sup>). Precise knowledge of the index of refraction is of crucial importance for emerging dispersion engineering technologies. Furthermore, utilizing this directed self-assembly approach enables the nanometer scale resolution required to develop the unique optical response and simultaneously provides high-throughput for potential device realization.
Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors (1992)

Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex vivo for their ability to inhibit Ca II in the albino rabbit eye after topical administration. Compound 11a was found to lower intraocular pressure (IOP) in both the alpha-CT ocular hypertensive albino rabbit and the normal albino rabbit, but was ineffective at lowering IOP in a hypertensive, pigmented monkey model. Since 11a was highly bound to ocular pigment, a series of less basic analogs was prepared. Examples in this series were both less extensively bound to ocular pigment and more active at reducing IOP in pigmented rabbits after topical dosing. Key examples displayed moderate reactivity toward glutathione.
<title>Content-based image retrieval for semiconductor manufacturing</title> (2000)

In the semiconductor manufacturing environment, defect imagery is used to diagnose problems in the manufacturing line, train automatic defect classification systems, and examine historical data for trends. Image management in semiconductor yield management systems is a growing cause of concern since many facilities collect 3000 to 5000 images each month, with future estimates of 12,000 to 20,000. Engineers at Oak Ridge National Laboratory (ORNL) have developed a semiconductor- specific content-based image retrieval architecture, also known as Automated Image Retrieval (AIR). We review the AIR system approach including the application environment as well as details on image interpretation for content-based image retrieval. We discuss the software architecture that has been designed for flexibility and applicability to a variety of implementation schemes in the fabrication environment. We next describe details of the system implementation including image processing and preparation, database indexing, and image retrieval. The image processing and preparation discussion includes a description of an image processing algorithm which enables a more accurate description of the semiconductor substrate (non-defect area). We also describe the features used that identify the key areas of the defect imagery. The feature indexing mechanisms are described next, including their implementation in a commercial database. Next, the retrieval process is described, including query image processing. Feedback mechanisms, which direct the retrieval mechanism to favor specified retrieval results, are also discussed. Finally, experimental results are shown with a database of over 10,000 images obtained from various semiconductor manufacturing facilities. These results include subjective measures of system performance and timing details for our implementation.