gebhart/patrepeval huggingface dataset:
Development of a high performance magnetic gear (2004)

This paper presents calculation and measurement results of a high performance permanent magnetic gear. The analysed permanent magnetic gear has a gear ratio of 5.5 and is able to deliver 27 Nm. The analysis has shown that special attention needs to be paid to the system where the gear is to be installed because of a low natural torsion spring constant. The analysed gear was also constructed in practice in order to validate the analysis and predict the efficiency. The measured torque from the magnetic gear was only 16 Nm reduced by the large end-effects. A systematic analysis of the loss components in the magnetic gear is also performed in order to figure out why the efficiency for the actual construction was only 81%. A large magnetic loss component originated in the bearings, where an unplanned extra bearing was necessary due to mechanical problems. Without the losses of magnetic origin in the bearings and less end-effects caused by relatively short stack, an impressive efficiency estimated at 96% can be obtained. Comparison with classical mechanical gears have shown that the magnetic gear has a better efficiency and a comparable torque per volume density. Finally it is concluded that the result in this paper may help to initiate a shift from mechanical gears to magnetic gears.
ChurnVis (2013)

In this paper, we present ChurnVis, a system for visualizing components affected by mobile telecommunications churn and subscriber actions over time. We describe our experience of deploying this system in a network analytics company for use in data analysis and presentation tasks. As social influence seems to be a factor in mobile telecommunications churn (the decision of a subscriber to leave a particular service provider), the visualization is based on a social network inferred from calling data between subscribers. Using this network, churn components, or groups of churners who are connected in the social network, are segmented out and trends in their static and dynamic attributes are visualized. ChurnVis helps analysts understand trends in these components in a way that respects the data privacy constraints of the service provider. Through this two pipeline approach, we are able to visualize thousands of churn components filtered from a social network of hundreds of millions of edges.
Dose‐Related Safety and Immunogenicity of Baculovirus‐Expressed Trivalent Influenza Vaccine: A Double‐Blind, Controlled Trial in Adult Patients with Non‐Hodgkin B Cell Lymphoma (2006)

In 27 patients randomized to receive commercial trivalent influenza vaccine (TIV) containing 15 microg of the hemagglutinin (HA) of influenza A (H3N2 and H1N1) and B virus or a recombinant vaccine (rHAO) containing 15, 45, or 135 microg of each HA, reactogenicity was minor. Among patients with similar prevaccination titers, 40% given 45 microg and 60% given 135 microg of rHAO developed an increase in influenza A/H3 neutralizing antibody levels; there were no increases in 4 given TIV. For each vaccine, the highest frequencies of increases in neutralizing antibody levels and the highest mean titers occurred in those given the 135- microg vaccine.
Comorbidity of Psychiatric and Alcohol/Drug Disorders: (1993)

Dual diagnosis as interpreted in clinical psychiatric practice is often not what the term means-two independent disorders. Commonly, addiction disorders are attributed to self medicating of "underlying" psychiatric disorders, there by, a contingency status. However, studies and clinical addiction practice show that drug and alcohol addiction must be afforded an independent status before accurate assessment and assignment of interactions in dual diagnosis can be made in clinical conditions. Studies also show rates for psychiatric comorbidity are low in addiction populations and rates for addictive disorders are high in psychiatric populations. If the common denominator is taken as addiction, then the perspective of the setting and examiner become crucial in determining prevalence rates for both disorders. Most importantly, effective treatment of either disorder will not occur unless an agreement on an independent status is accepted for both addictive and psychiatric disorders in any patient population setting.
Natural killer T cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL‐4 and eotaxin production (2004)

Although NKT cells have been found to be capable of modulating immune responses in several model systems, the role of NKT cells in allergy remains unclear. Using CD1 gene knockout (KO) mice, which lack NKT cells, we examined the function of NKT cells in the development of allergic inflammation induced by a common airborne human allergen, ragweed. The data showed that airway eosinophilia and mucus overproduction induced by ragweed were significantly reduced in CD1 KO mice, which was correlated with significantly lower allergen-driven IL-4 production and lower eotaxin responses in the airways of CD1 KO mice. Moreover, both ragweed-specific and total serum IgE levels in CD1 KO mice were significantly lower than those in control BALB/c mice. The reduced allergic reaction in CD1 KO mice is not due to intrinsic deficiency because they showed normal levels of immune cells and function. In addition, in vivo stimulation of NKT cells using their natural ligand, alpha-galactosylceramide, enhanced ragweed-induced airway eosinophilia, IL-4, and eotaxin production in control, but not CD1 KO mice. These data provide in vivo evidence for the involvement of NKT cells in the allergic mechanisms responsible for allergen-driven cytokine and chemokine production and airway inflammation.
A PUF design for secure FPGA-based embedded systems (2010)

The concept of having an integrated circuit (IC) generate its own unique digital signature has broad application in areas such as embedded systems security, and IP/IC counter-piracy. Physically unclonable functions (PUFs) are circuits that compute a unique signature for a given IC based on the process variations inherent in the IC manufacturing process. This paper presents the first PUF design specifically targeted for field-programmable gate arrays (FPGAs). Our novel design makes use of the underlying FPGA architecture, and unlike prior published PUFs, the proposed PUF can be naturally embedded into a design's HDL, consuming very little area, and does not require the use of hard macros with fixed routing. Measured results on the Xilinx Virtex-5 65 nm FPGA demonstrate PUF signatures to be both unique and reliable under temperature variation.
[Purification and characterization of cerebroside sulfatase activator]. (1983)

Cerebroside sulfatase (CSase) activator was isolated from human liver by acetone precipitation, anion-exchange chromatography, gel filtration and polyacrylamide gel electrophoresis. The CSase activator was a heat-stable protein with an isoelectric point of 4.54. Molecular weight (Mr) of the activator was estimated as 22,000 with the gel permeation and about 8,000 by gel electrophoresis in the presence of sodium dodecyl sulfate, suggesting that the native activator is a trimer of a subunit with Mr 8,000. The CSase activator formed a complex with an equimolar amount of cerebroside sulfate (CS), when examined by gel permeation experiments. The activator also bound to galactosylceramide and GM2 ganglioside but scarcely to GM1 ganglioside, and activated to some extent beta-N-acetyl-hexosaminidase A and beta-galactosidase, although the CSase activator could be clearly distinguished from the GM1 beta-galactosidase activator so far known. Though the affinity chromatography using glycolipid ligands, the CSase activator did not recognize sulfate group of CS, but appeared to have a relatively broad specificity for lipid-linked hexose.
The functional basis of face evaluation (2008)

People automatically evaluate faces on multiple trait dimensions, and these evaluations predict important social outcomes, ranging from electoral success to sentencing decisions. Based on behavioral studies and computer modeling, we develop a 2D model of face evaluation. First, using a principal components analysis of trait judgments of emotionally neutral faces, we identify two orthogonal dimensions, valence and dominance, that are sufficient to describe face evaluation and show that these dimensions can be approximated by judgments of trustworthiness and dominance. Second, using a data-driven statistical model for face representation, we build and validate models for representing face trustworthiness and face dominance. Third, using these models, we show that, whereas valence evaluation is more sensitive to features resembling expressions signaling whether the person should be avoided or approached, dominance evaluation is more sensitive to features signaling physical strength/weakness. Fourth, we show that important social judgments, such as threat, can be reproduced as a function of the two orthogonal dimensions of valence and dominance. The findings suggest that face evaluation involves an overgeneralization of adaptive mechanisms for inferring harmful intentions and the ability to cause harm and can account for rapid, yet not necessarily accurate, judgments from faces.
Highly Selective CO<sub>2</sub> Adsorption Accompanied with Low-Energy Regeneration in a Two-Dimensional Cu(II) Porous Coordination Polymer with Inorganic Fluorinated PF<sub>6</sub><sup>–</sup> Anions (2012)

High selectivity and low-energy regeneration for adsorption of CO(2) gas were achieved concurrently in a two-dimensional Cu(II) porous coordination polymer, [Cu(PF(6))(2)(4,4'-bpy)(2)](n) (4,4'-bpy = 4,4'-bipyridine), containing inorganic fluorinated PF(6)(-) anions that can act as moderate interaction sites for CO(2) molecules.
Caspase Activation in Alzheimer's Disease: Early to Rise and Late to Bed (2008)

It has been almost 15 years since the first report of apoptosis as a major mechanism of cell death associated with Alzheimer's disease (AD). Presently, whether neurons die through apoptosis or some other pathway is still a hotly debated issue. However, mounting evidence suggests a role for the activation of caspases and cleavage of critical cellular proteins during the progression of AD. The activation of apoptotic pathways may represent a protracted battle due to the presence of various anti-apoptotic molecules such as Bcl-2 whereby neurons do not immediately execute the apoptotic program but caspase activation occurs discretely at some low level. During this time, caspase cleavage of the amyloid precursor protein (APP), the adaptor protein GGA3 involved with beta-amyloid production, and tau may promote the formation of beta-amyloid (A beta) and neurofibrillary tangles (NFTs). Thus, not only may activation of caspases represent a terminal event associated with AD (i.e. cell death), but also a proximal event that promotes the pathology underlying this disease. Therefore, therapeutics aimed at preventing the activation and execution of apoptosis may provide an effective means of treating AD.
Phenotypic and molecular analysis of six human cell lines derived from patients with plasma cell dyscrasia (1999)

Cell lines RPMI 8226, JJN3, U266 B1, NCI-H929 (all EBV-) and ARH77 and HS-Sultan (both EBV+) have been extensively characterized in this study. EBV- lines expressed the phenotype (CD138-, CD19+, CD20+) whereas EBV+ were (CD138+, CD19-, CD20-). CD56 expression was restricted to EBV- cell lines, with the exception of U266 B1, whereas PCA-1 was strongly expressed on five of the six cell lines. Only EBV+ cell lines bound peanut-agglutinin (PNA). However, all cell lines bound the lectin Jacalin that binds the same receptor as PNA, irrespective of the receptors sialylation status. By RT-PCR and direct sequencing of their IgH V/D/J domains, ARH77 was demonstrated to use the germline sequence VH4-34/dm1/JH6b, whereas no arrangement was demonstrated for RPMI 8226, suggesting IgH gene deletion or mutation. HLA class I and II antigens were detected using HLA typing on all cell lines warranting their use as suitable targets for HLA-restricted cytotoxic T cells. By sensitive RT-PCR, mRNA for IL-6, IL-6R and TNFbeta was found expressed in all cell lines. IL-1 mRNA expression was predominantly associated with the EBV+ phenotype. Although mRNA for IL-3 and GM-CSF was never detected, transcripts for c-kit ligand and, more commonly, its receptor were. Likewise GM-CSF, M-CSF and erythropoietin mRNA transcripts were detected in the majority of cell lines.
Regional Alterations in Glucose Consumption and Metabolite Levels during Postischemic Recovery in Cat Brain (1985)

Local CMRgl (LCMRgl) and metabolite levels were measured in the same tissue samples following 4 h of recirculation after 1 h of occlusion of the middle cerebral artery in the cat. The rate of glucose utilization was calculated using direct measurement of tissue deoxyglucose-6-phosphate and using a "lumped" constant corrected in each sample for alterations in tissue glucose. Increased LCMRgl (compared with that in sham-operated animals) occurred in regions with only minor alterations in levels of lactate and phosphocreatine. By contrast, LCMRgl was markedly depressed in regions with major changes in lactate and high-energy phosphates. Interestingly, tissue levels of glucose and unphosphorylated deoxyglucose were abnormally elevated in regions with profound energy failure. These results indicate an inhibition of glucose utilization in regions damaged by ischemia, despite the persistent elevation of tissue lactate. Increased glucose metabolism at 4 h post ischemia was detected only in areas with minor anaerobic alteration of metabolite levels.
Interdigitation index – a parameter for differentiating between young and older skin specimens (2000)

BACKGROUND/AIMS: Quantitative morphometry developed rapidly during the last decade due to advances is computers and software. We wish to establish a simple baseline for the morphometric differences due to intrinsic ageing between young and old cohorts: the interdigitation index. It is an expression of the shape of the border between the epidermis and dermis. METHODS: We used volar forearm biopsies of women, since the volar forearm is usually not photodamaged. The biopsies were fixed in buffered formalin, embedded in paraffin and sectioned. Separate sections were stained by hematoxylin-eosin, by orcein and by dimethyl-methylene blue. We had seven female volunteers in each group; the young cohort had a mean age of 26.6 years, the older cohort 50.9 years. We chose a cohort that was just about postmenopausal, since in the future we wish to evaluate the effect of externally-applied agents on postmenopausal female skin and the earlier it is applied the better its chance of being effective. RESULTS: We found no difference between the young and older cohort with regard to epidermal thickness. We found a decrease of glycosaminoglycen (GAG) as measured by dimethyl-methylene blue staining. The results of the elastic staining by orcein, although in line with the reports in the literature, are not useful for evaluating the intrinsic ageing process, at least not by the simple percentage of area stained procedure. We introduced a new parameter: the interdigitation index. It is a simple measurement of the interdigitation in the epidermal-dermal junction, known to be diminished by age. This index was diminished by about 20% between the young and older cohort. CONCLUSIONS: Quantitative morphometry using simple epidermal and dermal measurements on biopsies of the volar forearm of women is suitable for following intrinsic ageing of the skin and offers a simple objective method for following the ageing process of the skin.
Computational modeling of an endovascular approach to deep brain stimulation (2014)

Together, these results suggest that endovascular DBS can serve as a complementary approach to stereotactic DBS in select cases.
Inhibition of thromboxane biosynthesis and platelet function by indobufen in type II diabetes mellitus. (1993)

Indobufen is a reversible inhibitor of platelet prostaglandin G/H-synthase. To verify the dose dependence of the antiplatelet effect of indobufen on ex vivo and in vivo indexes of thromboxane (TX) biosynthesis and TXA2-dependent platelet function, we studied nine patients with non-insulin-dependent diabetes mellitus (NIDDM). This was a randomized, double-blind, crossover study in which each patient was treated with three different daily regimens (50 mg BID, 100 mg BID, and 200 mg BID) of indobufen for 1 week, with a 7-day washout period between treatments. Urinary 11-dehydro-TXB2 excretion averaged 58.2 +/- 21.8 ng/h at baseline. TX metabolite excretion was reduced dose dependently by indobufen: by 67% at 50 mg BID, 72% at 100 mg BID, and 81% at 200 mg BID. Platelet cyclooxygenase activity, ATP release, collagen-induced platelet aggregation, and bleeding time also were modified dose dependently by indobufen. Biochemical demonstration of suppressed platelet TXA2 in vivo was accompanied by evidence of inhibited platelet function as assessed ex vivo. Under pathophysiological conditions, such as NIDDM, which are associated with enhanced TXA2 synthesis, more than 95% suppression of platelet cyclooxygenase activity may be necessary to produce virtually maximal inhibition of platelet TXA2 biosynthesis in vivo.
Topological phase transitions in functional brain networks (2019)

Functional brain networks are often constructed by quantifying correlations between time series of activity of brain regions. Their topological structure includes nodes, edges, triangles, and even higher-dimensional objects. Topological data analysis (TDA) is the emerging framework to process data sets under this perspective. In parallel, topology has proven essential for understanding fundamental questions in physics. Here we report the discovery of topological phase transitions in functional brain networks by merging concepts from TDA, topology, geometry, physics, and network theory. We show that topological phase transitions occur when the Euler entropy has a singularity, which remarkably coincides with the emergence of multidimensional topological holes in the brain network. The geometric nature of the transitions can be interpreted, under certain hypotheses, as an extension of percolation to high-dimensional objects. Due to the universal character of phase transitions and noise robustness of TDA, our findings open perspectives toward establishing reliable topological and geometrical markers for group and possibly individual differences in functional brain network organization.
An acoustic charge transport digitally programmable transversal filter (1989)

A monolithic 64-tap digitally programmable analog transversal filter is described that uses an acoustic charge transport (ACT) tapped delay line and integrated GaAs MESFET circuits for coefficient storage and tap weight circuitry. The device has 6-b tap weights, an input sampling rate of 360 MHz, and an output tap spacing corresponding to an output sampling rate of 130 MHz. This results in the effective execution of 8*10/sup 9/ multiply and sum operations per second in a 38-mm/sup 2/ chip that dissipates less than 2 W. This effective computational rate is limited in the present design by the spacing of the ACT delay line taps, which is dictated by the geometry of the tap weight circuits. The chip uses fully random-access tap weight memory, which is easier to interface to typical digital controllers than the usual shift-register storage approach. Tap address and tap weight data are applied as parallel 6-b words, and the data work is clocked into the address location by the application of an enable pulse. The tap weight circuits use monolithic capacitors and GaAs MESFET analog switches to realize a multiplying converter based on a C/2C ladder configuration with a sign-and-magnitude tap weight word format. A ladder accuracy of 7 b is achieved by compensating the ladder component values for parasitics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Expression of miRNAs and Their Cooperative Regulation of the Pathophysiology in Traumatic Brain Injury (2012)

Traumatic brain injury (TBI) is a leading cause of injury-related death and disability worldwide. Effective treatment for TBI is limited and many TBI patients suffer from neuropsychiatric sequelae. The molecular and cellular mechanisms underlying the neuronal damage and impairment of mental abilities following TBI are largely unknown. Here we used the next generation sequencing platform to delineate miRNA transcriptome changes in the hippocampus at 24 hours and 7 days following TBI in the rat controlled cortical impact injury (CCI) model, and developed a bioinformatic analysis to identify cellular activities that are regulated by miRNAs differentially expressed in the CCI brains. The results of our study indicate that distinct sets of miRNAs are regulated at different post-traumatic times, and suggest that multiple miRNA species cooperatively regulate cellular pathways for the pathological changes and management of brain injury. The distinctive miRNAs expression profiles at different post-CCI times may be used as molecular signatures to assess TBI progression. In addition to known pathophysiological changes, our study identifies many other cellular pathways that are subjected to modification by differentially expressed miRNAs in TBI brains. These pathways can potentially be targeted for development of novel TBI treatment.
Accelerating MapReduce with Distributed Memory Cache (2009)

MapReduce is a partition-based parallel programming model and framework enabling easy development of scalable parallel programs on clusters of commodity machines. In order to make time-intensive applications benefit from MapReduce on small scale clusters, this paper proposes a new method to improve the performance of MapReduce by using distributed memory cache as a high speed access between map tasks and reduce tasks. Map outputs sent to the distributed memory cache can be gotten by reduce tasks as soon as possible. Experiment results show that our prototype’s performance is much better than that of the original on small scale clusters. To our knowledge, this is the first effort to accelerate MapReduce with the help of distributed memory cache.
Direct modulation of the effective sensitivity of a CCD detector: a new approach to time‐resolved fluorescence imaging (2002)

In this paper a novel approach to frequency-domain fluorescence lifetime imaging (FLIM) is described. In a CCD camera a single pixel is defined by a charge pattern on a group of electrodes. By modulation of the pattern of voltages defining the pixel structure it is possible to modulate the sensitivity of the CCD at radio frequency. The modulation enhances the noise performance of the CCD, in contrast to the deterioration in performance seen when an intensifier stage is similarly modulated. The new technology has potential applications to a wide range of assays as well as in conventional FLIM applications. Unlike intensifier-based systems, the directly modulated CCD is physically small, inexpensive, robust and offers superior resolution and noise performance.