gebhart/patrepeval huggingface dataset:
Presence of somatostatin-28-(1-12) in hypothalamus and pancreas. (1982)

Acid extracts from rat pancreas and hypothalamus were analyzed for the presence of the antigenic determinant corresponding to the NH2 terminus of somatostatin-28 (SS28), using an antiserum directed against amino acids 1 to less than or equal to 11 of the SS28 molecule. On gel permeation chromatography the majority of the immunoreactive material from each tissue extract eluted in one zone compatible with a peptide of 1250 daltons. Purification of this immunoreactive material by reverse-phase HPLC and cation-exchange chromatography yielded two immunoreactive peptides from each tissue extract. The amino acid compositions of both peptides in pancreas and hypothalamus correspond to the fragment 1-12 of SS28. The more hydrophobic peptide from each tissue coeluted with synthetic SS28-(1-12) on HPLC, while the other one coeluted with synthetic SS28-(1-12)-amide. We conclude that the prosomatostatin fragment Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-OH is present in both rat hypothalamus and rat pancreas.
Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex (2009)

The Delta(4)-3-ketosteroid functionality is present in nearly all steroid hormones apart from estrogens. The first step in functionalization of the A-ring is mediated in humans by steroid 5alpha- or 5beta-reductase. Finasteride is a mechanism-based inactivator of 5alpha-reductase type 2 with subnanomolar affinity and is widely used as a therapeutic for the treatment of benign prostatic hyperplasia. It is also used for androgen deprivation in hormone-dependent prostate carcinoma, and it has been examined as a chemopreventive agent in prostate cancer. The effect of finasteride on steroid 5beta-reductase (AKR1D1) has not been previously reported. We show that finasteride competitively inhibits AKR1D1 with low micromolar affinity but does not act as a mechanism-based inactivator. The structure of the AKR1D1.NADP(+)*finasteride complex determined at 1.7 A resolution shows that it is not possible for NADPH to reduce the Delta(1-2)-ene of finasteride because the cofactor and steroid are not proximal to each other. The C3-ketone of finasteride accepts hydrogen bonds from the catalytic residues Tyr-58 and Glu-120 in the active site of AKR1D1, providing an explanation for the competitive inhibition observed. This is the first reported structure of finasteride bound to an enzyme involved in steroid hormone metabolism.
Monte Carlo and Molecular Dynamics Simulations in Polymer Science (1995)

Abstract Written by leading experts from around the world, Monte Carlo and Molecular Dynamics Simulations in Polymer Science comprehensively reviews the latest simulation techniques for macromolecular materials. Focusing in particular on numerous new techniques, the book offers authoritative introductions to solutions of neutral polymers and polyelectrolytes; dynamics of polymer melts, rubbers and gels, and glassy materials; thermodynamics of polymer mixing and mesophase formation, and polymers confined at interfaces and grafted to walls. Throughout, contributors offer practical advice on how to overcome the unique challenges posed by the large size and slow relaxation of polymer coils. Students and researchers in polymer chemistry, polymer physics, chemical engineering, and materials and computational science will all benefit from the cogent, step-by-step introductions contained in this important new book.
Stacked dielectric resonator antenna for multifrequency operation (1998)

A stacked dielectric resonator antenna (DRA), composed of an annular ring excited by a coaxial probe and two cylindrical dielectric resonators (CDRs), is studied experimentally for three-frequency band operation. A maximum frequency ratio of 1.75 is achieved between higher and lower frequencies, and quite similar radiation patterns are obtained at two of the separate operating frequencies. The middle frequency band offers different radiating properties. A minimum 10 dB impedance bandwidth of 4.9% is performed. The return loss, radiation patterns, and antenna gain of this configuration are reported. © 1998 John Wiley & Sons, Inc. Microwave Opt Technol Lett 18: 303–306, 1998.
Metal-in-gap record head (1982)

High density signal levels increase as the record head gap is reduced. When the gap is reduced, the optimum deep gap record field increases. With small gaps and high coercivity tapes, the wear resistant ferrites used to make standard heads saturate at the gap corners. This smears the record field gradient and performance suffers. Traditionally, the solution to this problem has been to make a ferrite core equipped with high saturation flux density Sendust pole tips. The record performance of tipped heads is excellent, but they are expensive and fragile because they are epoxied together, and their wear rate is much higher than ferrite heads. We have developed a process for vacuum depositing high permeability Sendust thin films on the gap faces of ferrite heads before gap spacer deposition. These metal in gap (MIG) heads can be glass bonded. The result is a long wearing, rugged, and inexpensive record head which gives optimum 80 KBPI performance on 860 Oe coercivity media using standard ferrite cores and gaps as small as 0.3μ. With a 250μ trackwidth, a tape speed of 19.1 cm/sec, and a frequency of 300 KHz (80 KFCI), MIG heads have achieved an RMS signal-to-wideband noise ratio of 30dB on high squareness isotropic tapes. Similar all-ferrite heads record only about half this signal. Construction and performance of MIG heads will be described.
Structure and Solvation in Ionic Liquids (2007)

This Account describes experimental data used to understand the structure of ionic liquids and solute-solvent interactions of both molecular solutes and dissolved metal complexes. In general, the structures of the ionic liquids determined from experimental data show good agreement with both simulated structures and solid-state structures. For all ionic liquids studied, strong charge ordering is found leading to long-range order even in the presence of a solute. For dissolved metal complexes, the ionic liquid is not innocent and a clear dependence on the speciation is observed with variations in both the cation and anion.
The GSM base station system and the related equipment (mobile communications) (2003)

A brief overview of the GSM (CEPT's Groupe Special Mobile) base station system (BSS) is given. The equipment needed to support this network entity and the specification of the equipment are presented. The use of the BSS equipment specification is described and the testing of the GSM base station systems is discussed. BSS network functions are outlined and the A-bis-interface is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
New synthetic reactions of allyl alkyl carbonates, allyl .beta.-keto carboxylates, and allyl vinylic carbonates catalyzed by palladium complexes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew synthetic reactions of allyl alkyl carbonates, allyl .beta.-keto carboxylates, and allyl vinylic carbonates catalyzed by palladium complexesJiro Tsuji and Ichiro MinamiCite this: Acc. Chem. Res. 1987, 20, 4, 140–145Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ar00136a003https://doi.org/10.1021/ar00136a003research-articleACS PublicationsRequest reuse permissionsArticle Views2776Altmetric-Citations354LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Survey of Additive Manufacturing Processes Applied on the Fabrication of Gears (2014)

The geometric complexity of mechanical components of mechatronic systems is a challenge to apply Additive Manufacturing. The focus of this study is to evaluate the potential of AM processes for the fabrication of different types of multistage spur gears, bevel gears, worm gears, Harmonic drive gears, cycloidal drives and pumps. The precision of different AM technologies is compared. Material behavior is investigated on a gear test rig. The opportunities and limitations of processes using plastics for the fabrication of gears are discussed in this paper.
A comparison between two 1.8GHz CMOS VCOs tuned by different varactors (1998)

Two 1.8GHz CMOS VCOs, based on a diode-varicap and an MOS-varicap, respectively, have been designed in a 0.8µm digital CMOS process and tested. Although the tuning range is larger for the MOS-varicap VCO, the overall performance of the diode-varicap VCO is superior to that of the MOS-varicap VCO. The comparison might give a different result by adopting a CMOS process that allows for shorter minimum transistor gate lengths.
Extraction of Desired Signal Based on AR Model with Its Application to Atrial Activity Estimation in Atrial Fibrillation (2008)

The use of electrocardiograms (ECGs) to diagnose and analyse atrial fibrillation (AF) has received much attention recently. When studying AF, it is important to isolate the atrial activity (AA) component of the ECG plot. We present a new autoregressive (AR) model for semiblind source extraction of the AA signal. Previous researchers showed that one could extract a signal with the smallest normalized mean square prediction error (MSPE) as the first output from linear mixtures by minimizing the MSPE. However the extracted signal will be not always the desired one even if the AR model parameters of one source signal are known. We introduce a new cost function, which caters for the specific AR model parameters, to extract the desired source. Through theoretical analysis and simulation we demonstrate that this algorithm can extract any desired signal from mixtures provided that its AR parameters are first obtained. We use this approach to extract the AA signal from 12-lead surface ECG signals for hearts undergoing AF. In our methodology we roughly estimated the AR parameters from the fibrillatory wave segment in the V1 lead, and then used this algorithm to extract the AA signal. We validate our approach using real-world ECG data.
EmCodeSyn: A visual framework for multi-rate data flow specifications and code synthesis for embedded applications (2009)

In this paper, a new framework EmCodeSyn is introduced for visual debugging, execution and code synthesis from multi-rate data flow based specifications. EmCodeSyn is an attempt to create a formal semantics based visual framework for specifying safety critical applications such as automotive control, avionics fly-by-wire control, etc. In contrast with SIMULINK/Stateflow, LabVIEW and other visual tools, EmCodeSyn is based on a synchronous programming paradigm akin to the polychronous language SIGNAL. The formalism on which this work is based, is called MRICDF (Multi-rate Instantaneous Channel Connected Data Flow). The specification formalism has relational semantics, which enables static rate-analysis for scheduling the computation in the code generation stage. Hierarchical data flow specification with minimal amount of control specification makes it easier for designers to compose existing MRICDF models to create larger ones. Once the feasibilty of an MRICDF design is verified, Code Synthesis is performed by the tool to generate C code. EmCodeSyn design methodology provides a visual framework for generating verifiable deterministic code from synchronous specification based on MRICDF formalism.
Extracellular Hsp90 mediates an NF‐κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment (2013)

Our results provide compelling support for eHsp90α as a transducer of signaling events culminating in an inflammatory and reactive stroma, thereby conferring properties associated with prostate cancer progression.
Reconfigurable Robots for Distributed Robotics (2000)

Small (roughly 116cm 3 ) &quot;scout&quot; robots with multiple movement capabilities are presented. Scouts contain a complement of sensors (cameras, vibration monitors, etc.) along with transmitters/receivers and microcontrollers for clandestine reconnaissance and other covert tasks. Scouts are teamed with larger &quot;ranger&quot; robots that have greater range, battery life, and computational resources. Together they form a distributed, reconfigurable robotic team. 1 Introduction Certain clandestine reconnaissance and surveillance tasks, along with other military functions in urban warfare, require the use of multiple small yet highly capable robots. The individual robots must be easily deployable and able to move efficiently yet traverse obstacles or uneven terrain. They must be able to sense their environment, act on their sensing, and report their findings. They must be able to be controlled in a coordinated manner. To support all of these requirements, we have designed a &quot;scout&quot; robot with a c...
Treatment of invasive or metastatic thymoma: Report of eleven cases (1981)

The clinical presentation and therapeutic modalities of 11 patients with invasive or metastatic thymoma are presented. Two patients had myasthenia gravis, and five had extrathoracic metastases. Survival exceeded five years in five patients, and four patients remain free of recurrence between 2.1 and 9.0 years after diagnosis. Surgery, with an attempt at complete resection, is the first step of therapy. A second thoracotomy for local relapse or attempt at curative resection was carried out in four patients. Radiotherapy to the mediastinum and/or metastatic sites was given to ten patients with doses ranging from 3600-6000 rads (median = 4500 rads) in the nine nonmyasthenic patients. Inclusion of supraclavicular fossae in the radiotherapy field is recommended because it was a site of relapse in two patients. Systemic therapies were given to eight patients. Objective responses were seen with two of various chemotherapeutic regimens. A combination of bleomycin, Adriamycin, cisplatin, and prednisone ("BAPP") produced a partial remission in two of five patients, during 12 and 4 months, respectively. Two of three patients responded to maytansine as a single agent after failure of other agents. Immunotherapy with intravenous Corynebacterium parvum or intradermal Methanol-Extraction Residue of bacillus Calmette-Guérin (MER-BCG) was ineffective in one patient each. The importance of combined modalities in the management of the disease is emphasized.
Raw Multi-Channel Audio Source Separation using Multi- Resolution Convolutional Auto-Encoders (2018)

Supervised multi-channel audio source separation requires extracting useful spectral, temporal, and spatial features from the mixed signals. the success of many existing systems is therefore largely dependent on the choice of features used for training. In this work, we introduce a novel multi-channel, multiresolution convolutional auto-encoder neural network that works on raw time-domain signals to determine appropriate multiresolution features for separating the singing-voice from stereo music. Our experimental results show that the proposed method can achieve multi-channel audio source separation without the need for hand-crafted features or any pre- or post-processing.
Promises and Challenges of Smac Mimetics as Cancer Therapeutics (2015)

Inhibitor of Apoptosis (IAP) proteins block programmed cell death and are expressed at high levels in various human cancers, thus making them attractive targets for cancer drug development. Second mitochondrial activator of caspases (Smac) mimetics are small-molecule inhibitors that mimic Smac, an endogenous antagonist of IAP proteins. Preclinical studies have shown that Smac mimetics can directly trigger cancer cell death or, even more importantly, sensitize tumor cells for various cytotoxic therapies, including conventional chemotherapy, radiotherapy, or novel agents. Currently, several Smac mimetics are under evaluation in early clinical trials as monotherapy or in rational combinations (i.e., GDC-0917/CUDC-427, LCL161, AT-406/Debio1143, HGS1029, and TL32711/birinapant). This review discusses the promise as well as some challenges at the translational interface of exploiting Smac mimetics as cancer therapeutics.
Investigating corrosion behaviors of anodized metallic implants by electrochemical analysis (2016)

Thesis (M.S.)--Wichita State University, College of Engineering, Dept. of Mechanical Engineering
Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon‐alpha, hydroxyurea, imatinib mesylate or 2‐chlorodeoxyadenosine (2009)

Abstract Cytoreductive therapy in systemic mastocytosis (SM) includes several drugs whose individual merit has not been well characterized. We retrospectively studied 108 Mayo Clinic patients who met the 2008 WHO diagnostic criteria for SM and received at least one cytoreductive drug. The numbers of patients who were evaluable for response to treatment with interferon‐alpha with or without prednisone (IFN‐α), hydroxyurea (HU), imatinib mesylate (IM) or 2‐chlorodeoxyadenosine (2‐CdA) were 40, 26, 22, and 22, respectively. The corresponding overall (major) response rates, according to recently published consensus criteria, were 53% (18%), 19% (0%), 18% (9%), and 55% (37%). The respective overall response rates in indolent SM, aggressive SM and SM associated with another clonal hematological nonmast cell lineage disease (SM‐AHNMD) were 60%, 60%, 45% for IFN‐α, 0, 0, 21% for HU, 14%, 50%, 9% for IM and 56%, 50%, 55% for 2‐CdA. The absence of mast cell mediator release symptoms in IFN‐α‐treated patients and presence of circulating immature myeloid cells in 2‐CdA‐treated patients predicted inferior response. TET2 mutational status did not influence treatment response. Although the major response rates with these four cytoreductive agents were still suboptimal and HU was mainly used in patients with SM‐AHNMD, the current study favors 2‐CdA or IFN‐α as first‐line current therapy in SM and identifies patients who are likely to respond to such therapy. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.
Stretchable Electronic Platform for Soft and Smart Contact Lens Applications (2017)

A stretchable platform with spherical‐shaped electronics based on thermoplastic polyurethane (TPU) is introduced for soft smart contact lenses. The low glass transition temperature of TPU, its relatively low hardness, and its proven biocompatibility (i.e., protection of exterior body wounds) fulfill the essential requirements for eye wearable devices. These requirements include optical transparency, conformal fitting, and flexibility comparable with soft contact lenses (e.g., hydrogel‐based). Moreover, the viscoelastic nature of TPU allows planar structures to be thermoformed into spherical caps with a well‐defined curvature (i.e., eye's curvature at the cornea: 9 mm). Numerical modeling and experimental validation enable fine‐tuning of the thermoforming parameters and the optimization of strain‐release patterns. Such tight control is proven necessary to achieve oxygen permeable, thin, nondevelopable, and wrinkle‐free contact lenses with integrated electronics (silicon die, radio‐frequency antenna, and stretchable thin‐film interconnections). This work paves the way toward fully autonomous smart contact lenses potentially for vision correction or sensing applications, among others.
Nondestructive positron-lifetime measurements during fatigue of austenitic stainless steel using a mobile positron beam (2000)

Nondestructive positron-lifetime measurements have been performed during stress-controlled symmetric fatigue of austenitic stainless steel up to failure for different applied stress amplitudes between 230 and 300 MPa. For this purpose a fatigue machine has been equipped with a mobile positron beam emitted from a 22 μCi (0.8 MBq) Se/7272As generator. A pronounced increase of the mean positron lifetime has been found within the first 10% of fatigue life. Saturation has been reached after 40% of fatigue life. The mean positron lifetime at failure depends strongly on the applied stress amplitude.
3D scaffolds co-seeded with human endothelial progenitor and mesenchymal stem cells: Evidence of prevascularisation within 7 days (2013)

Blood supply is a critical issue in most tissue engineering approaches for large defect healing. As vessel ingrowth from surrounding tissues is proven to be insufficient, current strategies are focusing on the neo-vascularisation process. In the present study, we developed an in vitro pre-vascularised construct using 3D polyurethane (PU) scaffolds, based on the association of human Endothelial Progenitor Cells (EPC, CD34+ and CD133+) with human Mesenchymal Stem Cells (MSC). We showed the formation of luminal tubular structures in the co-seeded scaffolds as early as day 7 in culture. These tubular structures were proven positive for endothelial markers von Willebrand Factor and PECAM-1. Of special significance in our constructs is the presence of CD146-positive cells, as a part of the neovasculature scaffolding. These cells, coming from the mesenchymal stem cells population (MSC or EPC-depleted MSC), also expressed other markers of pericyte cells (NG2 and αSMA) that are known to play a pivotal function in the stabilisation of newly formed pre-vascular networks. In parallel, in co-cultures, osteogenic differentiation of MSCs occurred earlier when compared to MSCs monocultures, suggesting the close cooperation between the two cell populations. The presence of angiogenic factors (from autologous platelet lysates) in association with osteogenic factors seems to be crucial for both cell populations' cooperation. These results are promising for future clinical applications, as all components (cells, growth factors) can be prepared in an autologous way.
Dan Morgan, Rising in the West: The True Story of an "Okie" Family from the Great Depression Through the Reagan Years (New York, NY: Alfred A. Knopf, 1992). 532 pp. $25.00, hardback (1993)

"Dan Morgan, Rising in the West: The True Story of an "Okie" Family from the Great Depression Through the Reagan Years (New York, NY: Alfred A. Knopf, 1992). 532 pp. $25.00, hardback" published on 01 Jan 1993 by Brill.
Residual cognitive effects of long-term cannabis use (2004)

Previous chapters of this book have addressed the question of whether cannabis can cause or potentiate frank psychiatric syndromes such as psychotic disorders. Of course, the great majority of cannabis users, including even those who have used cannabis for decades, do not appear to exhibit serious psychiatric disorders (Gruber and Pope, 1996; Johns, 2001). But what about more subtle impairments? Do long-term heavy cannabis users experience residual deficits in cognition, even if they stop using cannabis for a substantial period?