gebhart/patrepeval huggingface dataset:
Reduction Potentials of SO<sub>3</sub><sup>•-</sup>, SO<sub>5</sub><sup>•-</sup>, and S<sub>4</sub>O<sub>6</sub><sup>•3-</sup>Radicals in Aqueous Solution (1999)

Reduction potentials of the SO3•-, SO5•-, and S4O6•3- radicals in aqueous solutions are measured by pulse radiolysis at 294 K. These radicals are produced by reaction of •OH or N3• radicals with sulfite, peroxymonosulfate, and thiosulfate anions, respectively. The potentials for the couples SO3•-/SO32- and SO5•-/SO52- are determined from equilibrium constants with three reference couples of the phenoxyl/phenoxide type, i.e., those derived from phenol, 3-cresol, and tyrosine. The potential for PhO•/PhO- is redetermined against ClO2•/ClO2- and confirms the published value. The potentials for the other two phenols are determined against PhO•/PhO-. The potential for the SO3•-/SO32- couple is found to be 0.73 ± 0.01 V vs NHE. The potential for SO5•-/SO52- is found to be 0.81 ± 0.02 V. The reduction potential of the radical formed from the one-electron oxidation of thiosulfate, which exhibits a λmax at 375 nm, is also determined. This radical was identified before as either the monomeric S2O3•- or the dimeric S4O6•3-. Equilibrium measurements for this species, using N3• and the 4-cyanophenoxyl radical as references, support the dimeric assignment and yield a value of 1.07 ± 0.03 V for the reduction potential for the couple S4O6•3- /2S2O32-.
Development of a Traffic Signal Performance Measurement System (TSPMS) (2005)

The purpose of this research was to examine the type of performance measures that could be collected at an intersection and develop a system for automatically collecting these performance measures in the field. The authors began the research by conducting an assessment of the needs of the Texas Department of Transportation practitioners for an automated system to collect intersection and traffic signal performance measures. They then examined capabilities of some of the existing traffic signal controllers and detection systems to produce the desired performance measures. Based on the findings of the needs assessments and an evaluation of the limitation of the existing detection system, they developed a series of innovative performance measures that practitioners could use to assess traffic operations and the effectiveness of the signal timing at intersections. They then developed a prototype system for automatically collecting these data in the field. They installed the prototype system in two different locations that exhibited different operating characteristics and assessed the ability of the system to collect meaningful and appropriate performance measures.
Biosynthesis of Chiral Flavor and Aroma Compounds in Plants and Microorganisms (1989)

Capillary gas chromatographic determination of optical purities, investigation of the conversion of potential precursors, and characterization of enzymes catalyzing these reactions were applied to study the biogenesis of chiral volatiles in plants and microorganisms. Major pineapple constituents are present as mixtures of enantiomers. Reductions, chain elongation, and hydration were shown to be involved in the biosynthesis of hydroxy acid esters and lactones. Reduction of methyl ketones and subsequent enantioselective metabolization by Penicillium citrinum were studied as model reactions to rationalize ratios of enantiomers of secondary alcohols in natural systems. The formation of optically pure enantiomers of aliphatic secondary alcohols and hydroxy acid esters using oxidoreductases from baker's yeast was demonstrated.
A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells (2009)

We have developed a simple multi-layer microfluidic device by integrating a polydimethyl siloxane (PDMS) microfluidic channel and a porous membrane substrate to culture and analyze the renal tubular cells. As a model cell type, primary rat inner medullary collecting duct (IMCD) cells were cultured inside the channel. To generate in vivo-like tubular environments for the cells, a fluidic shear stress of 1 dyn/cm(2) was applied for 5 hours, allowing for optimal fluidic conditions for the cultured cells, as verified by enhanced cell polarization, cytoskeletal reorganization, and molecular transport by hormonal stimulations. These results suggest that the microfluidic device presented here is useful for resembling an in vivo renal tubule system and has potential applications in drug screening and advanced tissue engineering.
Analysis of μ-Contact Printed Protein Patterns by SPR Imaging with a LED Light Source (2004)

We demonstrate the characterization of mu-contact printed protein patterns and analysis of protein-protein interactions by two-dimensional (2-D) surface plasmon resonance imaging (SPRi). Advancements in SPRi image quality from employing a light emitting diode (LED) as the light source are described. We show that a LED offers an ideal point source that can eliminate interference artifacts and speckles found when using a laser source. The attainable thickness resolution in fixed-angle imaging is comparable to that of a monochromatic source, providing a solid foundation for quantitative analysis with the system. The SPR imaging technique reported here affords sub-nanometer thickness sensitivity and micrometer lateral resolution, allowing for convenient studies of biomolecular interactions and surface morphologies of ultrathin films. Spatially well-defined protein patterns of bacterial toxins were obtained by microcontact printing using a polydimethylsiloxane (PDMS) stamp on a functionalized self-assembled monolayer on Au. The influence of protein concentration in the inking solution on transfer efficiency was investigated, and a nonlinear correlation was observed between the solution concentration and the amount of protein immobilized on the surface. Quantitative analysis of protein interaction was performed with toxin-specific antibody, showing a concentration-dependent relationship that verifies the retention of biological activity of the protein after printing. The study demonstrates the feasibility and effectiveness of using LEDs as light sources in SPR imaging, opening doors for developing compact SPR instruments for direct, sensitive, and label-free detection of biohazardous molecules.
Novel strategies for identification and therapeutic application of minor histocompatibility antigens (2007)

T cells recognizing the highly immunogenic minor histocompatibility antigens (mHags) expressed by hematopoietic and tumor cells may be powerful tools in the battle against hematological malignancies. However, mHag-specific immunotherapy is still in its infancy, since currently only few clinically useful mHags are identified, and since the exploration of T cell based immunotherapy for the treatment of cancer was initiated only a decade ago. The scope of thesis is to tackle these issues by 1) identifying and facilitating the identification of novel clinically relevant mHags and 2) investigating the immunotherapeutic potential of mHag-specific CD4+ T cells in vitro as well as in a preclinical murine model. The thesis describes the identification of the first HLA class II-restricted mHag with a truly hematopoietic tissue expression. The mHag is encoded by the CD19 gene, which is not only highly expressed on B cells, but also on their malignant derivatives. The identification of the CD19-derived mHag is performed using a novel genetic fine-mapping strategy, called zygosity-genotype correlation analysis. The genome-wide application of this strategy is easy and rapid as we demonstrate with the molecular characterization of the novel SLC19A1-derived mHag. In addition, we also outline a directed strategy to make significant progress toward wide scale application of mHag-specific immunotherapy. Furthermore, we utilize the rationale behind this directed strategy towards the identification of new mHags using a reverse identification approach. We describe the advantages of reverse identification and provide an extensive list of putative mHags that are predicted using reliable antigen-processing and HLA-binding algorithms combined with databases containing all currently known genes and genotyped SNPs. The second part of the thesis shows the feasibility of transferring a TCR derived from mHag-specific CD4+ human T cells into recall antigen (tetanus toxoid; TT)-specific CD4+ T cells. The TCR-transgenic cells acquire mHag specificity, and expand efficiently in vitro via stimulation of their intrinsic TT-specific TCR. Next, similar dual-specific T cells as well as the parent mHag-specific T cells are used as sole treatment for established multiple myeloma tumors in immunodeficient mice. This adoptive immunotherapy with sole mHag-specific CD4+ T cells is very effective against tumor in the bone marrow. However, the mice suffer from extramedullary tumor relapses, which are in vitro but not in vivo susceptible to further T cell therapy. These results seem also relevant for the clinic, since the relapse of multiple myeloma at extramedullary sites is a known complication in patients treated with DLI. Finally, the discussion describes how the current findings may contribute to the improvement of immunotherapeutic strategies based on mHag-specific (CD4+) T cells.
Prediction of the Coding Sequences of Mouse Homologues of KIAA Gene: III. The Complete Nucleotide Sequences of 500 Mouse KIAA-homologous cDNAs Identified by Screening of Terminal Sequences of cDNA Clones Randomly Sampled from Size-fractionated Libraries (2003)

We have conducted a human cDNA project to predict protein-coding sequences (CDSs) in large cDNAs (> 4 kb) since 1994, and the number of newly identified genes, known as KIAA genes, already exceeds 2000. The ultimate goal of this project is to clarify the physiological functions of the proteins encoded by KIAA genes. To this end, the project has recently been expanded to include isolation and characterization of mouse KIAA-counterpart genes. We herein present the entire sequences and the chromosome loci of 500 mKIAA cDNA clones and 13 novel cDNA clones that were incidentally identified during this project. The average size of the 513 cDNA sequences reached 4.3 kb and that of the deduced amino acid sequences from these cDNAs was 816 amino acid residues. By comparison of the predicted CDSs between mouse and human KIAAs, 12 mKIAA cDNA clones were assumed to be differently spliced isoforms of the human cDNA clones. The comparison of mouse and human sequences also revealed that four pairs of human KIAA cDNAs are derived from single genes. Notably, a homology search against the public database indicated that 4 out of 13 novel cDNA clones were homologous to the disease-related genes.
Non-contact radiofrequency-induced reduction of subcutaneous abdominal fat correlates with initial cardiovascular autonomic balance and fat tissue hormones: safety analysis (2015)

Our analysis shows that the selective-field RF treatment is safe and efficient for reduction of subcutaneous abdominal fat. While the treatment increases the immediate sympathetic response of the body to deep tissue heating, no sustained change in autonomic function could be recorded at 1 month follow-up. The observed correlation between initial VLF spectral power and waist circumference reduction at follow-up, as well as the association of initial adiponectin values and immediate autonomic response to the treatment might be instrumental for decisions on body contouring strategies.
Electrolytes for advanced lithium ion batteries using silicon-based anodes (2019)

Recent progress in electrolytes from the liquid to the solid state for Si-based anodes is comprehensively summarized in this review article.
Research Status and Prospects of Particle-Free Silver Conductive Ink (2018)

Conductive inks are mainly used in the printed electronics industry. Particle-free conductive inks are prepared from organometallic compounds or complexes as precursors. They have the characteristics of preventing agglomeration and settling, not easily clogging the nozzles, and having a low heat treatment temperature, suitable for inkjet printing. Starting from precursors, the development statuses of conductive inks using silver acetate, silver citrate, silver neodecanoate, silver oxalate, silver tartrate, silver nitrate, and silver oxide as precursors were respectively introduced, summarized the main problems that existed, and put forward the outlook.
REFLECTS – a European CRAFT project for the development of a bifacial silicon solar cell module (2007)

The objective of the REFLECTS project (Novel bifacial single substrate solar cells utilising reflected solar radiation) is the development of a cost effective, high efficiency bifacial silicon solar module exploiting the light reflected from behind the cells for energy generation. A bifacial rear contact silicon solar cell using a simple processing sequence is developed. Mechanical grinding is deployed for the definition of the emitter and base contact regions. The rear surface structure is then utilised as a mask for the self-aligned metallization of the bifacial rear contact cells applying the OECO (obliquely evaporated contacts) - technique. We achieved an efficiency of 20.5 % under illumination from the non-metallised cell side whereas the efficiency is as high as 17.0 % when illuminated from the metallised side. A string of 5 bifacial cells is mounted and encapsulated on a non-concentrating reflector developed within the project. Applying the reflector enhances the short circuit current by 38 %.
Reconfigurability in planetary surface vehicles : Modelling approaches and case study (2006)

Reconfigurability is being recognized as increasingly important for space systems for reasons of efficiency, extensibility and mission robustness. Planetary Surface Vehicles (PSVs), that may be used in future manned exploration missions, can especially benefit from reconfigurability. Two frameworks for studying reconfigurable systems are proposed that allow for analyzing systems that undergo changes over time. The first framework, using Non-Homogeneous Markov Models (NHMM), allows for identifying useful configurations or states. The second framework, based on control theory, enables issues such as reconfiguration time, and dynamics of the reconfiguration process to be assessed. The application of these models is shown for a PSV in a future human exploration mission that can reconfigure to respond to changing terrain conditions. The results for the specific case considered show that reconfigurability improves the performance of the vehicle over the course of a simulated sortie by approximately 30%.
The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial (2016)

The current study was conducted to assess the effects of vitamin D-K-calcium co-supplementation on endocrine, inflammation, and oxidative stress biomarkers in vitamin D-deficient women with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was performed on 60 vitamin D-deficient women diagnosed with PCOS aged 18-40 years old. Participants were randomly allocated into 2 groups to intake either 200 IU vitamin D, 90 μg vitamin K plus, 500 mg calcium supplements (n=30), or placebo (n=30) twice a day for 8 weeks. Endocrine, inflammation, and oxidative stress biomarkers were quantified at the beginning and the end of the study. After 8 weeks of intervention, compared with the placebo, vitamin D-K-calcium co-supplementation resulted in a significant reduction in serum-free testosterone (- 2.1±1.6 vs.+0.1±1.0 pg/ml, p<0.001) and dehydroepiandrosterone sulfate (DHEAS) levels (- 0.8±1.0 vs.-0.1±0.5 μg/ml, p=0.006). In addition, a significant increase in plasma total antioxidant capacity (TAC) (+ 75.7±126.1 vs.-80.4±242.8 mmol/l, p=0.005) and a significant difference in plasma malondialdehyde (MDA) concentrations (+ 0.03±0.6 vs.+1.4±2.4 μmol/l, p=0.005) was observed following the supplementation with vitamin D-K-calcium compared with the placebo. A trend toward a greater decrease in luteinizing hormone was observed in vitamin D-K-calcium co-supplement group compared to placebo group (- 7.0 vs.-1.2 IU/l, p=0.09). We did not find any significant effect of vitamin D-K-calcium co-supplementation on prolactin, follicle-stimulating hormone, 17-OH progesterone, inflammatory markers, and glutathione levels. Overall, vitamin D-K-calcium co-supplementation for 8 weeks among vitamin D-deficient women with PCOS had beneficial effects on serum DHEAS, free testosterone, plasma TAC, and MDA levels.
Approaching optimality for solving SDD systems (2010)

We present an algorithm that on input of an $n$-vertex $m$-edge weighted graph $G$ and a value $k$, produces an {\em incremental sparsifier} $\hat{G}$ with $n-1 + m/k$ edges, such that the condition number of $G$ with $\hat{G}$ is bounded above by $\tilde{O}(k\log^2 n)$, with probability $1-p$. The algorithm runs in time $$\tilde{O}((m \log{n} + n\log^2{n})\log(1/p)).$$ As a result, we obtain an algorithm that on input of an $n\times n$ symmetric diagonally dominant matrix $A$ with $m$ non-zero entries and a vector $b$, computes a vector ${x}$ satisfying $||{x}-A^{+}b||_A
Human Leukocyte Antigen (HLA)-Linked Control of Susceptibility to Pulmonary Tuberculosis and Association with HLA-DR Types (1983)

To demonstrate human leukocyte antigen (HLA)-linked control of susceptibility to pulmonary tuberculosis, 25 multiple-case families were tissue typed for class I and class II HLA specificities. Eight non-HLA genetic markers were also examined for any indication of other genetic factors that might influence the Mycobacterium tuberculosis infection. Observations on estimated HLA haplotype segregation in the sibs suggest that 84% of the affected sibs shared significantly more often than expected a common haplotype with each other than the normal unaffected sibs (P less than 0.001). Also, there was a skewed transmission of DR2 to diseased offspring from diseased parents (21 of 27) and to diseased offspring from healthy parents (15 of 17) in contrast to the transmission of DR2 from either group of parents to healthy offspring (six of 15 and 10 of 16, respectively). The segregation of non-HLA polymorphisms did not deviate significantly from the expected figures. These data provide strong evidence in favor of DR2-associated susceptibility to pulmonary tuberculosis.
Attenuation and Phenotypic Stability of Influenza B/Texas/l/84 Cold-Adapted Reassortant Virus: Studies in Hamsters and Chimpanzees (1989)

The temperature sensitivity, level of attenuation, and phenotypic stability of an influenza B/Texas/1/84 X B/Ann Arbor/1/66 cold-adapted (ca) reassortant virus that received the RNA segments that encode the hemagglutinin and neuraminidase surface glycoproteins from the B/Texas/84 wild-type virus and the remaining six RNA segments from the B/Ann Arbor/66 ca donor virus were evaluated. In comparison to wild-type virus, the ca reassortant was restricted in replication in the upper and lower respiratory tracts of hamsters and chimpanzees. This clearly demonstrated that the six transferable RNA segments of the B/Ann Arbor/66 ca donor virus specify the attenuation phenotype for animals with a 37 degrees C core body temperature. In addition, the ca virus retained the temperature-sensitive (ts) phenotype after replication in hamsters and chimpanzees. To further evaluate its phenotypic stability, the ca reassortant virus was isolated after 6-15 d of replication in hamsters that were immunosuppressed with cyclophosphamide, and the isolates were tested for their temperature sensitivity in vitro and for their level of replication in immunocompetent hamsters. The isolated viruses retained their ts and attenuation phenotypes even after prolonged replication in vivo. Thus, the B/Ann Arbor/66 ca donor virus can transfer the desired properties of attenuation and phenotype stability to its reassortants. The findings support the continued evaluation of ca reassortant influenza B virus vaccines in humans, including fully susceptible children.
Assessment of safety leadership among senior managers in China's coal mining industry (2021)

The factors giving rise to the safety leadership of senior managers in the coal mining industry are underexplored. We conducted 24 semistructured interviews with experienced senior managers in this industry. We used hermeneutic content analysis for the interview content, identified five safety leadership dimensions of senior mangers, and designed the Safety Leadership Scale in Coal Mines in China. Data from 845 participants in nine coal mines were analyzed with confirmatory factor analysis (CFA). We followed a two-step approach, involving data pruning and a second-order CFA, and validated a 21-item measure that shows good validity and reliability. The secondorder CFA results show that the measure yielded an acceptable fit. Our results can be used to estimate the safety leadership level among senior managers in China's coal mining industry.
Electronic structure and redox properties of the clusters [Ru3O(CH3CO2)6L3]n+ (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structure and redox properties of the clusters [Ru3O(CH3CO2)6L3]n+John A. Baumann, Dennis J. Salmon, Stephen T. Wilson, Thomas J. Meyer, and William E. HatfieldCite this: Inorg. Chem. 1978, 17, 12, 3342–3350Publication Date (Print):December 1, 1978Publication History Published online1 May 2002Published inissue 1 December 1978https://pubs.acs.org/doi/10.1021/ic50190a007https://doi.org/10.1021/ic50190a007research-articleACS PublicationsRequest reuse permissionsArticle Views1388Altmetric-Citations184LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
COLD SHOCK DOMAIN PROTEIN 3 is involved in salt and drought stress tolerance in Arabidopsis (2013)

Cold shock proteins (CSPs) of bacteria are produced in response to cold and function as RNA chaperones that are essential for cold adaptation. Arabidopsis thaliana COLD SHOCK DOMAIN PROTEIN 3 (AtCSP3) shares a domain with bacterial CSPs and is involved in acquisition of freezing tolerance. Our previous study revealed that many of the genes that are down regulated in an AtCSP3 knockout mutant (atcsp3-2) are functionally associated with responses to salt and drought as well as cold. Here, we examined the involvement of AtCSP3 in salt and drought stress tolerance. We found that AtCSP3 is induced during salt and drought stresses, and is regulated by ABA. A knockout mutant of AtCSP3 (atcsp3-2) showed lower survival rates after salt and drought stress treatments. Conversely, the AtCSP3-overexpressing plants displayed higher survival rates after treatment with these stresses. Most of the genes that were down regulated in the atcsp3-2 mutant were found to be inducible upon salt and drought stresses, and upregulated in the AtCSP3-overexpressors. Together, our data demonstrates that AtCSP3 is involved in the regulation of salt and drought stress tolerance in Arabidopsis.