gebhart/patrepeval huggingface dataset:
The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization (1991)

We have examined whether sympathetic neurones that have lost the potential to be rescued by protein and RNA synthesis inhibitors after a period of nerve growth factor (NGF) deprivation are irreversibly committed to die. We found that 15 h after withdrawal of NGF from 7-day cultures of neonatal rat superior cervical ganglion neurones, 50% of the neurones lost the potential to be rescued by cycloheximide but that NGF rescued most of the neurones. By 22 h after NGF withdrawal, only 10% of the neurones were rescued by inhibition of macromolecular synthesis with cycloheximide, puromycin, or actinomycin D, but as many as 60-80% of the neurones were rescued by NGF. This is after the time at which a DNA "ladder," consistent with cell death by apoptosis, was first detected (18 h). As long as 27 h of NGF withdrawal was required before 50% of the neurones lost the potential to be rescued by NGF. The survival-promoting agent 8-(4-chlorophenylthio)cyclic AMP (CPTcAMP) or depolarization with 50 mM KCl (HK) rescued neurones with kinetics similar to those of NGF, and rescue by all three agents did not require protein synthesis. Thus, NGF, CPTcAMP, and HK can rescue neurones deprived of NGF at much later times than either protein or RNA synthesis inhibitors by acting at the posttranslational level, a finding suggesting that initiation of the cell death programme in sympathetic neurones is not an irreversible step.
STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 78. NEW ASPECTS ON THE INDUCED ASYMMETRIC ADDITION OF DIALKYL PHOSPHITE TO ALDIMINES—AN EFFECTIVE SYNTHESIS OF CHIRAL 1-ARYLPHOSPHONOGLYCINE DERIVATIVES (1993)

Abstract Addition of dialkyl phosphites to Schiff bases derived from (R)-2-methoxy-1-phenylethylamine or (R)-phenylglycine methyl ester afforded (1R, 1′R)-1-arylphosphonoglycine derivatives with moderate to high diastereoselectivity. The influence of catalysts and solvents and the structural effects of the substrates on this stereochemical process were reported.
New active-R sine wave oscillators: application in high frequency CPFSK wave modulation (1991)

Some new active-R tunable sinewave oscillators using operational amplifiers (OAs) and only two resistors are proposed. Analysis based on a two-pole-OA model indicates the possibility of stable and extended range sine wave generation by single register control at low sensitivities. The applicability of these oscillators for the generation of continuous phase frequency-shift keyed (CPFSK) waves at relatively high frequency bands has been examined employing a scheme consisting of the microprocessor control of an appropriately weighted switch resistor in accordance with a certain digital code. The proposed designs have been experimentally verified and some test results are included.
Parametric Quality-Estimation Model for Adaptive-Bitrate-Streaming Services (2017)

The use of adaptive-bitrate-streaming services over networks has been increasing in recent years. The quality of adaptive-bitrate-streaming services is primarily affected by the video resolution, the audio and video bitrate, bitrate adaptation, stalling due to a lack of playout buffer, and the content length. Therefore, service providers should monitor quality in real time to confirm the normality of their services. To accurately monitor quality, a model that can be used for quality estimation should be developed. To develop such a model, we first conducted extensive subjective quality assessment tests. We then developed a model using the subjective data obtained in the tests. Finally, we verified the performance of the proposed model by applying it to unknown datasets (different from the training datasets used to develop the model) and confirmed its high quality-estimation accuracy.
<i>Ex Vivo</i> Expansion and Gene Therapy Using Cord Blood CD34 <sup>+</sup> Cells (1993)

CD34+ cells can be efficiently isolated from cord blood by sequential Percoll, Ficoll-Hypaque, and immunomagnetic bead separation. This population, containing up to 25% progenitor cells and 0.2-1% stem cells, defined by a long-term culture-initiating cell (LTC-initiating cell) assay, can be expanded in vitro in the presence of a specific combination of cytokines resulting in a > 100,000-fold increase in cells, a > 2,000-fold increase in progenitors, and an 18- to 20-fold increase in LTC-initiating cells. These latter populations can be efficiently transfected with a retroviral vector expressing a mutated dihydrofolate-reductase gene that confers methotrexate resistance.
Adult nasolacrimal duct obstruction (1994)

Tear production resulting from obstruction of the nasolacrimal duct is a common ophthalmic problem. The diagnosis and treatment of this condition require a thorough understanding of the lacrimal apparatus and its ocular and nasal relationships. Idiopathic or primary acquired nasolacrimal duct obstruction is a syndrome of unknown etiology. Of all nontraumatic forms, it accounts for the vast majority of cases found in adults. The authors discuss a number of potential causes, some of them iatrogenic and discuss the technique of dacryocystorhinostomy, the standard surgical treatment, in detail.
Regulation of natural killer cell activity by macrophages in the rheumatoid joint and peripheral blood. (1984)

Recently, in another study, we observed that indomethacin, a prostaglandin synthetase inhibitor, significantly increased NK activity in both normal and rheumatoid arthritis (RA) peripheral blood (PB) but not in RA synovial fluid (SF). Because macrophages are a major source of prostaglandins, we examined the effect of macrophage-enriched adherent cells (AC) on NK activity as measured by a 3-hr Cr-release assay with K 562 cells. The removal of AC resulted in increased (p less than 0.01) NK activity in both normal and RA PB. In contrast, the removal of AC from RA SF resulted in a significant decrease (p less than 0.001) of NK activity. By using only nonadherent cells (NAC), NK activity in RA SF and synovial tissue (ST) was significantly reduced when compared to autologous RA PB (p less than 0.001). Enhancement of NK activity of SF NAC by both poly I:C and IL 2 was not dependent on AC. Mixing experiments demonstrated that the addition of synovial AC for 16 hr increased NK activity of synovial NAC to a level similar to that of unseparated mononuclear cells, whereas autologous PB AC suppressed NK activity of PB NAC. PB AC, when added to SF NAC, also increased NK activity. Supernatants from synovial mononuclear cells were stimulatory of synovial NAC NK activity, whereas normal PB mononuclear supernatants were suppressive. These observations document 1) a significant reduction of NAC-mediated NK activity in the rheumatoid joint as compared to PB from the same patient, and 2) that AC modulate NK activity differently in the rheumatoid joint as compared to RA or normal PB.
Self-supervised Co-training for Video Representation Learning (2020)

The objective of this paper is visual-only self-supervised video representation learning. We make the following contributions: (i) we investigate the benefit of adding semantic-class positives to instance-based Info Noise Contrastive Estimation (InfoNCE) training, showing that this form of supervised contrastive learning leads to a clear improvement in performance; (ii) we propose a novel self-supervised co-training scheme to improve the popular infoNCE loss, exploiting the complementary information from different views, RGB streams and optical flow, of the same data source by using one view to obtain positive class samples for the other; (iii) we thoroughly evaluate the quality of the learnt representation on two different downstream tasks: action recognition and video retrieval. In both cases, the proposed approach demonstrates state-of-the-art or comparable performance with other self-supervised approaches, whilst being significantly more efficient to train, i.e. requiring far less training data to achieve similar performance.
Structure of the hormone binding domain of human .beta.1 thyroid hormone nuclear receptor: Is it an .alpha./.beta. barrel? (1993)

To understand the structure of the hormone binding domain (HBD) of human beta 1 thyroid hormone nuclear receptor (h-TR beta 1), truncated h-TR beta 1 fragments, MD32 (M169-D456), KD29 (K201-D456), DD28 (D211-D456), KD25 (K235-D456), and KP28 (K201-P448), were analyzed by circular dichorism (CD). MD32 and KD29 show intense CD spectra with double minima at 222 and 208-210 nm, indicating the presence of extensive regions of alpha-helix. DD28 and KD25 have spectra which are reduced in intensity with minima around 215 nm, characteristic of a beta-sheet. The observed spectra are compatible with sequence analysis which predicts that HBD contains alternating stretches of alpha-helix and beta-strand. These extensive decreases in secondary structure in DD28 and KP28 in which the predicted first beta-strand or last alpha-helix was deleted, respectively, were accompanied by the loss of hormone binding activity. On the basis of these results, we suggest a new model for h-TR beta 1 consisting of the known DNA binding domain linked by an alpha-helical hinge to the HBD, with the tertiary structure of an alpha/beta barrel. The model is compatible with previous chemical and genetic studies on the structure of this protein.
SHORTER NOTICES (1996)

Journal Article SHORTER NOTICES Get access PAUL THOMPSON PAUL THOMPSON University of Essex Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CXI, Issue 442, June 1996, Pages 795-b–796, https://doi.org/10.1093/ehr/CXI.442.795-b Published: 01 June 1996
The Affective and Cognitive Impacts of Perceived Touch on Online Customers' Intention to Return in the Web-based eCRM Environment (2007)

Electronic Customer Relationship Management (ECRM) systems focus on a website as the interaction channel for creating a one-to-one relationship with customers via various “touch” options. The intention of such technologies is to affectively and cognitively impact on online customers’ intention to return to the website. To capture the influence of eCRM systems, we define a construct, Perceived Touch, to differentiate the customer’s perception of the touch received from the actual level of touch deployed. We report the results of an empirical study that provides evidence that Perceived Touch positively influences customers’ Behavioral Intention to Return via both affective and cognitive routes. Our results show that Perceived Touch provides a theoretical underpinning for eCRM system design and suggests that e-business managers invest in the design and evaluation of the users’ perception of touch options and pay special attention to affective quality manipulation.
Invention (1999)

In the European Renaissance the term invention has many senses, several of which inform poetic theory and literary criticism: a 'discovery', a 'finding', the 'faculty of discovery' but also the 'thing found'; something close to 'imagination', 'wit', and positively or pejoratively a 'technique' or 'artifice'. Dominating the concept of poetic invention is the meaning of inventio in (mainly Latin) rhetorical theory. The noun inventio corresponds to the verb invenire [to find, to discover, to come upon]. In rhetorical treatises, at the place of invenire we often find reperire [to find, to discover] or excogitare [to think of, to find by reflection]. The most lucid and accessible account of the process of 'finding' that informs rhetorical composition is given by Cicero, in his De partitione oratoria (especially 1.3-2.5). The orator derives his 'power' [vis] from two sources: first, his res (the 'things' of the speech: subject-matter, including both ideas and facts); second, his verba (the words chosen to convey subject-matter). The finding of subject-matter precedes the finding of words, and although inventio is sometimes loosely applied to both kinds of finding, generally inventio concerns only subject-matter, not words, which are the province of elocutio [eloquence]. In composing a speech the orator has in mind an aim, an intention (quaestio: either unlimited, in the sense of a general enquiry, or specific, a causa). In order to achieve this aim, the orator must find subject-matter that will both convince his audience (literally, produce faith, confidence, or belief, fides, in those he wishes to persuade) and move the audience's emotions.
Adipose Tissue–Derived Stem Cells Enhance Bioprosthetic Mesh Repair of Ventral Hernias (2010)

Preseeded and injected adipose tissue-derived stem cells engraft, migrate, proliferate, and enhance the vascularity of porcine acellular dermal matrix grafts at the musculofascial/graft interface. These cells can thus enhance incorporation of porcine acellular dermal matrix into the abdominal wall after repair of ventral hernias.
Systematic Testing of Convolutional Neural Networks for Autonomous Driving (2017)

We present a framework to systematically analyze convolutional neural networks (CNNs) used in classification of cars in autonomous vehicles. Our analysis procedure comprises an image generator that produces synthetic pictures by sampling in a lower dimension image modification subspace and a suite of visualization tools. The image generator produces images which can be used to test the CNN and hence expose its vulnerabilities. The presented framework can be used to extract insights of the CNN classifier, compare across classification models, or generate training and validation datasets.
An Adaptive, Humanlike Robot Hand with Selective Interdigitation: Towards Robust Grasping and Dexterous, In-Hand Manipulation (2019)

This paper presents an adaptive robot hand that is capable of performing selective interdigitation, robust grasping, and dexterous, in-hand manipulation. The design consists of underactuated, compliant, anthropomorphic robot fingers that are implemented with flexure joints based on elastomer materials (urethane rubber). The metacarpophalangeal (MCP) joint of each finger can achieve both flexion/extension and abduction/adduction. The use of differential mechanisms simplifies the actuation scheme, as we utilize only two actuators for four fingers, achieving affordable dexterity. The two actuators offer increased power transmission during the execution of grasping and manipulation tasks. The importance of the thumb is highlighted with the use of two individual tendon-routing systems for its control. An analytical model is employed to derive the rotational stiffness of the finger flexure joints and select appropriate actuators. Selective interdigitation allows the robot hand to switch from pinch grasp configurations to power grasp configurations optimizing the performance of the device for specific objects. The design can be fabricated with off-the-shelf materials and rapid prototyping techniques, while its efficiency has been validated using an extensive set of experimental paradigms that involved the execution of complex tasks with everyday life objects.
Stability of the Cellulase of <i>Trichoderma reesei</i> under use conditions (1980)

Enzyme stability studies have been reinvestigated under the conditions used for cellulose hydrolysis (pH 4.8, 50 degrees C, 24 hr). The cellobiohydrolase (CBH) component as measured on Avicel is less stable than other enzymes of the cellulase complex, and is 60% inactivated by merthiolate (and other Hg compounds) under the above conditions. Endo-beta-1,4-glucanase is much more stable, and more resistant to merthiolate and other compounds. Under unshaken conditions the Avicelase of the Rutgers strain C 30 shows greater stability to heat than that of other available strains. Biocides must be selected not only for their ability to prevent contamination, but also for their compatibility with cellulases. Tetracycline and chlortetracycline are inexpensive, effective in very low concentrations, have no harmful effect on the enzymes, and are compatible with the yeasts that subsequently grow on the sugar solutions to produce alcohol. Attempts have been made to stabilize the enzymes by chemical modification in such a way as to maintain their solubility. Glutaraldehyde treatment greatly increased the enzyme size, lowered the pI values, and gave a slight shift in the pH activity curve. There was, unfortunately, no increase in enzyme stability, and the activity of enzymes on solid celluloses was adversely affected. Shaking greatly reduced the hydrolysis of Avicel by Trichoderma reesei C 30 enzyme. The adverse effect was accompanied by a decrease in recoverable enzyme and protein.
A luminance-contrast-aware disparity model and applications (2012)

Binocular disparity is one of the most important depth cues used by the human visual system. Recently developed stereo-perception models allow us to successfully manipulate disparity in order to improve viewing comfort, depth discrimination as well as stereo content compression and display. Nonetheless, all existing models neglect the substantial influence of luminance on stereo perception. Our work is the first to account for the interplay of luminance contrast (magnitude/frequency) and disparity and our model predicts the human response to complex stereo-luminance images. Besides improving existing disparity-model applications (e.g., difference metrics or compression), our approach offers new possibilities, such as joint luminance contrast and disparity manipulation or the optimization of auto-stereoscopic content. We validate our results in a user study, which also reveals the advantage of considering luminance contrast and its significant impact on disparity manipulation techniques.
Design of Motor Intelligent Monitoring and Fault Diagnosis System Based on LoRa (2021)

Aiming at the characteristics of low intelligence of the current motor cluster and superconducting electrical equipment monitoring system, high construction and maintenance costs of wired transmission methods. The wireless sensor network constructed by LoRa technology is applied to the motor operating state monitoring system, while the data transmission efficiency of the system is improved by optimizing the topology of the wireless sensor network (WSN) and processing the transmission data redundancy. The system uses STM32F407ZET6 as the main controller, builds an offline operating state library, and uses HMM model for training to achieve real-time acquisition and fault diagnosis of the status information of the cluster system motor's voltage, current, speed, and position. Practical application shows that the system is running well and can realize the acquisition of the motor's running status and fault diagnosis.
Value-based leadership. A prescription for reforming the American health care system. (1997)

Many reforms have been suggested for health care in the last 30 years yet they are mainly treating symptoms rather than getting at the root cause of the problems. The underlying problem is a lack of vision for the health care system. There is no comprehensive, uniform vision of American medicine rooted in the needs of our society. This vision should be based on the values that significantly challenge physicians: patient satisfaction, patient empowerment, cost effectiveness and the appropriate use of resources, patent access, and continuous quality improvement based on appropriate data techniques.
Association of Low Pa<scp>co</scp> <sub>2</sub> with Central Sleep Apnea and Ventricular Arrhythmias in Ambulatory Patients with Stable Heart Failure (1998)

Data on patients with heart failure in this study are consistent with the physiologic notion that a low PaCO2 results in ventilatory instability and central apnea during sleep. The positive predictive value of a low PaCO2 for central sleep apnea is 78%. The prevalence of ventricular tachycardia was 20 times greater in hypocapnic patients than in eucapnic patients.
Oncogenic NOTCH1 Control of MYC and PI3K: Challenges and Opportunities for Anti-NOTCH1 Therapy in T-Cell Acute Lymphoblastic Leukemias and Lymphomas (2008)

The identification of activating mutations in NOTCH1 in the majority of T-cell acute lymphoblastic leukemias and lymphomas (T-ALL) has brought much interest in inhibiting NOTCH1 signaling as therapeutic target in this disease. Small-molecule inhibitors of the gamma-secretase complex, which mediates a critical proteolytic cleavage required for NOTCH1 activation, hold the promise of becoming an effective molecular therapy against relapsed and refractory T-ALL. Recent progress in the elucidation of the transcriptional regulatory networks downstream of oncogenic NOTCH1 has uncovered a central role of NOTCH1 signaling in promoting leukemic cell growth and revealed an intricate circuitry that connects NOTCH1 signaling with MYC and the PI3K-AKT signaling pathway. The identification of the downstream effector pathways controlled by NOTCH1 should pave the way for the rational design of anti-NOTCH1 therapies for the treatment of T-ALL.
Further characterization of the interaction between L-selectin and its endothelial ligands (1992)

L-Selectin is a lectin-like receptor on lymphocytes which mediates their attachment to high endothelial venules (HEV) within lymph nodes. Previous work has identified HEV-associated endothelial ligands for L-selectin as sialylated, fucosylated and sulphated glycoproteins of approximately 50 kDa and approximately 90 kDa (Sgp50 and Sgp90). The interaction of L-selectin with these ligands is carbohydrate directed, reflecting the involvement of its amino-terminal, calcium-type lectin domain. It has been reported, and we have confirmed, that anti-Ly22 blocks the adhesive function of L-selectin without reducing its binding to a carbohydrate- based ligand PPME (phosphomannan monoester core from Hansenula hostii). The epitope for this monoclonal antibody depends on the epidermal growth factor (EGF) domain of L-selectin. We demonstrate that anti-Ly22 inhibits the interaction of L-selectin with both of the Sgps, thus establishing that the interaction of L-selectin with HEV can be accounted for by the Sgps. Furthermore, the interaction of trypsin fragments of Sgp50 with L-selectin is inhibitable both by an antibody that maps to the lectin domain and by anti-Ly22. These findings raise the possibility that anti-Ly22 is affecting the function of the lectin domain of L-selectin rather than directly antagonizing the EGF domain. Toward a further characterization of L-selectin's carbohydrate specificity, we show that Sgp50 is partially inactivated by the linkage-specific Newcastle Disease virus sialidase (alpha 2,3 linkage). We additionally demonstrate that a sialyl Lewis x-related tetrasaccharide can interact with L-selectin, as has also been demonstrated for E-selectin and P-selectin.
Synchronization of input and output measurements using a Kalman filter (2006)

Kalman filters are used when data from different sensors is combined to obtain a suboptimal estimation of a dynamic system's state. In most applications, the sensor data enters the filter in two places: some data is fed to the inputs of the dynamic system while other data is used as reference measurements of the system's outputs. In order to yield the best possible estimations, both types of sensors have to be well synchronized, but a hardware synchronization mechanism is not always available. In this paper, the Kalman filter is modified to estimate both the system's state and the time delay between input and output measurements. Simulations show that an accurate software synchronization can be achieved by using this method and that the state estimates improve largely.