gebhart/patrepeval huggingface dataset:
One-Pot Hydrothermal Synthesis of Benzalkonium-Templated Mesostructured Silica Antibacterial Agents (2018)

Novel mesostructured silica microparticles are synthesized, characterized, and investigated as a drug delivery system (DDS) for antimicrobial applications. The materials exhibit a relatively high density (0.56 g per 1 g SiO<sub>2</sub>) of benzalkonium chloride (BAC), pore channels of 18 Å in width, and a high surface area (1500 m<sup>2</sup>/g). Comparison of the small-angle X-ray diffraction (SAXRD) pattern with Barrett-Joyner-Halenda (BJH) pore size distribution data suggests that the 18 Å pores exhibit short-range ordering and a wall thickness of ca. 12 Å. Drug release studies demonstrate pH-responsive controlled release of BAC without additional surface modification of the materials. Prolonged drug release data were analyzed using a power law (Korsmeyer-Peppas) model and indicate substantial differences in release mechanism in acidic (pH 4.0, 5.0, 6.5) versus neutral (pH 7.4) solutions. Microbiological assays demonstrate a significant time-dependent reduction in Staphylococcus aureus and Salmonella enterica viability above 10 and 130 mg L<sup>-1</sup> of the synthesized materials, respectively. The viability of cells is reduced over time compared to control samples. The findings will help in widening the use of BAC as a disinfectant and bactericidal agent, especially in pharmaceutical and food industries where Gram-positive and Gram-negative bacterial contamination is common.
Analysis of fundamental frequency for near term suicidal risk assessment (2002)

Among the many clinical decisions that psychiatrists must make, assessment of a patient's risk of committing suicide is definitely among the most important, complex and demanding. Clinical experience has shown that successful predictions of suicidality were often based on the patient's voice independent of content. Vocal patterns associated with dynamic expressiveness were designated as one of the most distinguishable features in the voices of suicidal patients at imminent risk. This paper investigates this phenomenon in an effort to explore the discriminating ability of jitter (period-to-period fluctuations in fundamental frequency) among suicidal and nonsuicidal patients. First, a wavelet transform based glottal cycle duration estimation technique is employed for the voiced/unvoiced decision and fundamental frequency (F0) estimation. Second, F0 perturbations are computed for each voiced segment in the F0 contour. Statistical analyses showed that F0 perturbations differ significantly (p=0.0069) between suicidal and nonsuicidal subjects' speech. Finally, a maximum likelihood classifier was developed, which obtained a correct classification score of 80%.
Tensor properties of optically encoded second-harmonic generation in semiconductor-microcrystallite-doped glasses (1991)

Tensor properties of second-harmonic generation in optically encoded semiconductor-microcrystallite-doped glasses are measured and shown to be consistent with encoding of a DC electric field in the glasses. Semiconductor bandgaps 20 nm above and below the second-harmonic wavelength exhibit the expected deviation from Kleinman symmetry.
A Multi-Memristive Unit-Cell Array With Diagonal Interconnects for In-Memory Computing (2021)

Memristive crossbar arrays can be used to realize matrix-vector multiplication (MVM) operations in constant time complexity by exploiting the Kirchhoff’s circuit laws. This is enabled by the parallel read of the entire array in a single time step. However, parallel writing is prohibitive in such arrays due to limitations on the current that could be accumulated along the wires. Hence, loading the matrix elements into such an array still incurs significant time penalty. Another key challenge is the achievable computational precision. To overcome these challenges, we propose a unit-cell array design where each unit-cell comprises four memristive devices each attached to a selection transistor. Moreover, the array is organized in such a way that the selection transistors can be turned on in a diagonal fashion. We experimentally demonstrated this concept by fabricating a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$2\times 2$ </tex-math></inline-formula> unit-cell array based on projected phase-change memory (PCM) devices in 90 nm CMOS technology. It is shown that using the diagonal connections, the write operations can be parallelized while maintaining the current limit of the back-end-of-the-line metallization. Moreover, the increase in write time due to having more devices per unit-cell is minimized through a combination of single-shot and iterative programming schemes. Finally, we present experimental results on MVM operations that demonstrate improved computational precision exceeding that of a 4-bit fixed-point implementation.
Additively Manufactured Compliant Hybrid Gas Thrust Bearing for sCO2 Turbomachinery: Experimental Evaluation and Fluid-Structure Model Predictions (2020)

Abstract The following paper presents rotating test results and advances an analytical predictive fluid-structure model for a new type of gas lubricated thrust bearing fabricated using direct metal laser melting (DMLM). The bearing concept in the present study is a compliant hybrid gas thrust bearing that uses external pressurization to increase load carrying capacity, where the testing campaign in the present study was only focused on steady state static performance. The need for the bearing concept comes from enabling highly efficient supercritical carbon dioxide (sCO2) turbomachinery by replacing oil-lubricated bearings with process gas lubrication. Leveraging the process gas of the turbomachine for bearing lubrication results in lowered bearing power loss [1], simplified mechanical design, and allows for novel oil-free hermetic drivetrains resulting in an efficient emission-free system [2,3]. The new concept utilizes hydrostatic pressurization on individual tilting pads flexibly mounted with hermetic squeeze film dampers (HSFD). The paper focuses on rotating tests of a 173mm outer diameter gas thrust bearing in air up to 10krpm and hydrostatic inlet pressures to 365psi (2.52MPa). The influence of thrust runner speed and bearing inlet pressure on force deflection characteristics and load carrying capability of the gas film were experimentally evaluated. The present work also advances a predictive fluid-structure thrust bearing model using an isothermal ideal-gas based compressible Reynolds flow equation directly coupled to a lumped stiffness element possessing axial and rotational degrees of freedom. The rotating testing demonstrated load capability of 1,816 lbs (8.1KN), which equates to a thrust bearing unit load of 67psi (0.46 MPa). Gas film force-deflection curves reveal a nonlinear relationship between thrust load and film clearance. Comparison of film thickness values with the predictive model show good agreement under high load and inlet pressure, however deviate as load and pressure decrease. Load capability was shown to increase with increasing hydrostatic inlet pressure while the increase in thrust runner speed revealed a small decrease in load capacity.
Phosphopeptide Separation Using Radially Aligned Titania Nanotubes on Titanium Wire (2015)

Phosphoproteomic analysis offers a unique view of cellular function and regulation in biological systems by providing global measures of a key cellular regulator in the form of protein phosphorylation. Understanding the phosphorylation changes between normal and diseased cells or tissues offers a window into the mechanism of disease and thus potential targets for therapeutic intervention. A key step in these studies is the enrichment of phosphorylated peptides that are typically separated and analyzed by using liquid chromatography mass spectrometry. The mesoporous titania beads/particles (e.g., Titansphere TiO2 beads from GL Sciences Inc., Japan) that are widely used for phosphopeptide enrichment are expensive and offer very limited opportunities for further performance improvement. Titiania nanotube arrays have shown promising characteristics for phosphopeptide separation. Here we report a proof-of-concept study to evaluate the efficacy of nanotubes on Ti-wire for phosphoproteomics research. We used titania nanotubes radially grown on titanium wires as well as the commercial beads to separate phosphopeptides generated from mouse liver complex tissue extracts. Our studies revealed that the nanotubes on metal wire provide comparable efficacy for enrichment of phophopeptides and offer an ease of use advantage versus mesoporous beads, thus having the potential to become a low cost and more practical material/methodology for phosphopeptide enrichment in biological studies.
Abstract 1925: Trifluoromethylated artemisinin dimers demonstrate a potent anti-cancer activity in vitro and in vivo (2012)

Abstract Beside their widely recognised efficacy as antimalaric drugs, artemisinin derivatives are also known for their cytotoxic properties since the early nineties. More recently, artemisinin dimers (ADs) were shown to possess an increased potential as anti-cancer agents due to their ability to inhibit cancer cells proliferation in the low nanomolar range. Taking advantage of an original chemistry, we synthesized a new series of trifluoromethylated artemisnin dimers which proved to be particularly potent depending on the size and nature of the linker. Different mode of linkage were performed by either carbon 16 or carbon 10 and were tested in vitro and in vivo. Best combination was found in a hybrid linking position delivering non-symmetrical C10-C16 ADs. One of the lead compound of this series, F98458 demonstrated a moderate (but statiscally significative) anti-tumor activity in mice against a human melanoma xenograft that is, to our knowledge, the first demonstration of in vivo antitumor properties of ADs in preclinical models. Many efforts to understand the molecular origin of the cytotoxic effect of monomeric artemisinin derivatives have been undertaken. One of the aims of this study was to investigate the mechanism of action of ADs in comparison with artemisinin: the antimalaric drug artesunate, a representative monomeric derivative of artemisinin, is known to induce DNA damage and ROS generation while our ADs did not under the same experimental conditions. Moreover ADs did not induce apoptosis (caspase 3/7, annexin V), leading us to investigate cell death related to senescence and autophagy. We have also synthesized partially reduced ADs possessing only one endoperoxide functionality. These compounds did show the same potency than non reduced ADs, underlaying that a tight molecular recognition is involved in its biological response. All these observations suggest that monomeric artemisinin derivatives such as artesunate and ADs possess distinct modes of action. The high in vitro potency associated with the in vivo response led us to synthesize affinity probes in order to identify the molecular target of ADs which could provide fundamental informations for further developpement of these compounds as anti-cancer agents. This work currently underway will also be discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1925. doi:1538-7445.AM2012-1925
Active Combustion Control of Diesel HCCI Engine: Combustion Timing (2008)

<div class="htmlview paragraph">We propose a model based control strategy to adapt the injection settings according to the air path dynamics on a Diesel HCCI engine. This approach complements existing airpath and fuelpath controllers, and aims at accurately controlling the start of combustion. For that purpose, start of injection is adjusted based on a Knock Integral Model and intake manifold conditions. Experimental results are presented, which stress the relevance of the approach.</div>
TiO2/carbon dots decorated reduced graphene oxide composites from waste car bumper and TiO2 nanoparticles for photocatalytic applications (2018)

Upcycling waste car bumper to value added carbon based nanomaterials has been achieved through facile catalytic pyrolysis. As synthesized TiO2 nanoparticles has been used for the first time as catalyst during pyrolysis process of the plastic waste. The quality and the performance of the produced carbon nanomaterials have been evaluated through different characterization techniques. The results show that, while rGO were produced from the thermal pyrolysis of waste car bumper in absence of TiO2 catalyst, rGO decorated with carbon dots have been produced in presence of TiO2 catalyst. Interestingly, simultaneous TiO2 rutile to anatase phase transformation and carbon nanomaterials formation has been occurred upon the catalytic transformation of the waste car bumper, however, an expected anatase to rutile transformation has been observed upon thermal treatment of TiO2 in the absence of the bumper. The photocatalytic performance of the created TiO2/CDs/rGO has been tested for the photocatalytic degradation of methylene blue. This paper provides a first attempt as an innovative approach to the upcycling waste into novel and high performance carbon nanomaterials for the application in photocatalysis. This innovative approach can be utilized to create various carbon nanocomposites utilizing metal oxides as catalyst and different plastic waste system as a carbon resource.
Asynchronous Ranging Method using Estimated Frequency Differences in Wireless Sensor Networks (2008)

무선 센서망에서 이동노드의 위치를 추정하는데 센서노드의 클럭주파수 차이는 TOF 추정에 중요한 파라메타이며, 이동노드와 고정노드 간의 거리 추정에 크게 영향을 미친다. IEEE802.15.4a에서는 별도의 유선 등에 의한 망동기 공급이 없는 상태에서도 주파수 차이에 둔감한 비동기 TWR 및 SDS-TWR 거리 추정 방식을 제안하고 있다. 그러나 제안된 비동기 TWR 및 SDS-TWR 방식은 여전히 노드 쌍에 따른 주파수 차이, 프레임 처리 시간, 프레임 처리 시간 차이 등에 의한 영향을 충분히 제거하지 못하고 있다. 특히 주파수 차이가 큰 저가의 발진기 사용, 서로 다른 하드웨어 및 소프트웨어에서 동작하는 센서노드는 더 큰 위치추정 오류를 유발할 수 있다. 본 논문은 주파수 차이를 추정하는 방식을 제안하고, 기존의 TWR 및 SDS-TWR 방식에 적용하였다. 시뮬레이션을 통하여 주파수 차이 추정을 적용한 제안된 방식은 주파수 차이의 영향을 감소시켜 TWR 및 SDS-TWR 등의 성능을 개선시켰으며, 25cm 이하의 위치오류가 발생하는 것을 확인하였다. The clock frequency difference of sensor nodes is one of main parameters in TOF estimation and affect to degrade ranging algorithms to estimate positions of mobile nodes in wireless sensor networks. The specification of IEEE802.15.4a describes asynchronous TWR and SDS-TWR insensitive to frequency difference without any additional network synchronization. But the TWR and SDS-TWR can not eliminate sufficiently the effect of frequency difference of node pair, packet processing delay and its difference. Especially use of low cost oscillator with wide range offset, sensor node with different hardware and software can make the positioning errors worse. We propose an estimation method of frequency differences, and apply the measured frequency differences to TWR and SDS-TWR. We evaluate the performance of the proposed algorithm with simulation, and make certain that the proposed method enhances the performance of existing algorithms with positioning errors less than 25 cm.
Cysteine degradation gene yhaM, encoding cysteine desulfidase, serves as a genetic engineering target to improve cysteine production in Escherichia coli (2017)

Cysteine is an important amino acid for various industries; however, there is no efficient microbial fermentation-based production method available. Owing to its cytotoxicity, bacterial intracellular levels of cysteine are stringently controlled via several modes of regulation, including cysteine degradation by cysteine desulfhydrases and cysteine desulfidases. In Escherichia coli, several metabolic enzymes are known to exhibit cysteine degradative activities, however, their specificity and physiological significance for cysteine detoxification via degradation are unclear. Relaxing the strict regulation of cysteine is crucial for its overproduction; therefore, identifying and modulating the major degradative activity could facilitate the genetic engineering of a cysteine-producing strain. In the present study, we used genetic screening to identify genes that confer cysteine resistance in E. coli and we identified yhaM, which encodes cysteine desulfidase and decomposes cysteine into hydrogen sulfide, pyruvate, and ammonium. Phenotypic characterization of a yhaM mutant via growth under toxic concentrations of cysteine followed by transcriptional analysis of its response to cysteine showed that yhaM is cysteine-inducible, and its physiological role is associated with resisting the deleterious effects of cysteine in E. coli. In addition, we confirmed the effects of this gene on the fermentative production of cysteine using E. coli-based cysteine-producing strains. We propose that yhaM encodes the major cysteine-degrading enzyme and it has the most significant role in cysteine detoxification among the numerous enzymes reported in E. coli, thereby providing a core target for genetic engineering to improve cysteine production in this bacterium.
Isolation and Structure of the Marine Sponge Cell Growth Inhibitory Cyclic Peptide Phakellistatin 1 (1993)

A new cell growth inhibitory (P-388 murine leukemia ED50 7.5 micrograms/ml) cycloheptapeptide designated phakellistatin 1 was isolated from two Indo-Pacific sponges, Phakellia costata and Stylotella aurantium. Structural elucidation was accomplished utilizing high field nmr, amino acid analyses, and mass spectral techniques (fab, tandem ms/ms), followed by chiral gas chromatographic procedures for absolute configuration assignments (all S-amino acid units). By these methods phakellistatin 1 [1] was found to be cyclo (Pro-Ile-Pro-Ile-Phe-Pro-Tyr), and this assignment was finally confirmed by an X-ray crystal structure determination.
Use of an Isogenic Mutant Constructed in <i>Moraxella catarrhalis</i> To Identify a Protective Epitope of Outer Membrane Protein B1 Defined by Monoclonal Antibody 11C6 (1999)

Moraxella catarrhalis-induced otitis media continues to be a significant cause of infection in young children, prompting increased efforts at identifying effective vaccine antigens. We have previously demonstrated that M. catarrhalis expresses specific outer membrane proteins (OMPs) in response to iron limitation and that this organism can utilize transferrin and lactoferrin for in vitro growth. One of these proteins, which binds human transferrin, is OMP B1. As the human host presents a naturally iron-limited environment, proteins, like OMP B1, which are expressed in response to this nutritional stress are potential vaccine antigens. In this study, we have developed monoclonal antibody (MAb) 11C6, which reacts to a surface-exposed epitope of OMP B1 expressed by M. catarrhalis 7169. This antibody was used to clone ompB1, and sequence analysis suggested that OMP B1 is the M. catarrhalis homologue to the transferrin binding protein B described for pathogenic Neisseriaceae, Haemophilus influenzae, Actinobacillus pleuropneumoniae, and M. catarrhalis. Expression of recombinant OMP B1 on the surface of Escherichia coli confers transferrin binding activity, confirming that this protein is likely involved in iron acquisition. In addition, ompB1 was used to construct an isogenic mutant in M. catarrhalis 7169. This mutant, termed 7169b12, was used as the control in bactericidal assays designed to determine if OMP B1 elicits protective antibodies. In the presence of MAb 11C6 and human complement, wild-type 7169 demonstrated a 99% decline in viability, whereas the ompB1 isogenic mutant was resistant to this bactericidal activity. Further analysis with MAb 11C6 revealed the presence of this OMP B1 epitope on 31% of the clinical isolates tested. These data suggest that OMP B1 is a potential vaccine antigen against M. catarrhalis infections.
Isolation of a dextranase constitutive mutant of Lipomyces starkeyi and its use for the production of clinical size dextran (1995)

A derepressed and partially constitutive mutant for dextranase of Lipomyces starkeyi was selected after ethyl methane sulphonate mutagenesis by zone clearance on blue dextran agar plates. The mutant produced dextranase when grown on glucose, fructose and sucrose as well as on dextran, and more enzyme was produced by the mutant than by the parental strain when grown on 1% dextran. The pH and temperature optima for the mutant dextranase were 5.5 and 55 degrees C, respectively. Dextranase produced on sucrose produced more isomaltose and less glucose after dextran hydrolysis than the equivalent enzyme produced on dextran. The clinical size dextran (average mol. wt of 75,000 +/- 25,000) yield of mixed culture fermentation with the mutant and Leuconostoc mesenteroides was 94% of the total dextran produced.
Identification of Distinctive Volatile Compounds in Fish Sauce (2002)

To make clear the distinctive odorants of fish sauce, addition tests were carried out with respect to deodorized fish sauce samples. Volatiles from the headspace gas of nontreated fish sauce and deodorized fish sauce were characterized by gas chromatography-olfactometry and gas chromatography-mass spectrometry. Four compounds contributing to the distinctive odor of fish sauce were 2-methylpropanal, 2-methylbutanal, 2-ethylpyridine, and dimethyl trisulfide. Addition tests (quantitative descriptive analysis) with respect to the four odorants showed that contributors to the fishy aroma were 2-ethylpyridine and dimethyl trisulfide and that all four odorants contributed to the sweaty aroma. Furthermore, the fecal note of fish sauce was essential with 2-ethylpyridine and dimethyl trisulfide, and the rancid note was essential with all four odorants.
DTM (2005)

This paper proposes an approach for pixel transformation of the displayed image to increase the potential energy saving of the backlight scaling method. The proposed approach takes advantage of human visual system characteristics and tries to minimize distortion between the perceived brightness values of the individual pixels in the original image and those of the backlight-scaled image. This is in contrast to previous backlight scaling approaches which simply match the luminance values of the individual pixels in the original and backlight-scaled images. Moreover, the proposed dynamic backlight scaling approach, which is based on tone mapping, is amenable to highly efficient hardware realization because it does not need information about the histogram of the displayed image. Experimental results show that the dynamic tone mapping for backlight scaling method results in about 35% power saving with an effective distortion rate of 5% and 55% power saving for a 20% distortion rate.