gebhart/patrepeval huggingface dataset:
NitroxylFluor: A Thiol-Based Fluorescent Probe for Live-Cell Imaging of Nitroxyl (2017)

Detection of nitroxyl (HNO), the transient one-electron reduced form of nitric oxide, is a significant challenge owing to its high reactivity with biological thiols (with rate constants as high as 10<sup>9</sup> M<sup>-1</sup> s<sup>-1</sup>). To address this, we report a new thiol-based HNO-responsive trigger that can compete against reactive thiols for HNO. This process forms a common N-hydroxysulfenamide intermediate that cyclizes to release a masked fluorophore leading to fluorescence enhancement. To ensure that the cyclization step is rapid, our design capitalizes on two established physical organic phenomena; the alpha-effect and the Thorpe-Ingold effect. Using this new trigger, we developed NitroxylFluor, a selective HNO-responsive fluorescent probe. Treatment of NitroxylFluor with an HNO donor results in a 16-fold turn-on. This probe also exhibits excellent selectivity over various reactive nitrogen, oxygen, and sulfur species and efficacy in the presence of thiols (e.g., glutathione in mM concentrations). Lastly, we successfully performed live cell imaging of HNO using NitroxylFluor.
Evaluation of <i>ZAR1</i> and <i>SFRP4</i> methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I (2014)

ZAR1 and SFRP4 qMSP could be used as potential biomarker for CC diagnosis.
Main forms of immunoreactive cardionatrin in atrial extracts and in atrial-specific granules (1985)

Conference Article| December 01 1985 Main forms of immunoreactive cardionatrin in atrial extracts and in atrial-specific granules T. GEOFFREY FLYNN; T. GEOFFREY FLYNN *Departments of Biochemistry, Ontario, Canada K7L 3N6 Search for other works by this author on: This Site PubMed Google Scholar ADOLFO J. DE BOLD; ADOLFO J. DE BOLD †Departments of Pathology, Queen's University, Ontario, Canada K7L 3N6‡Hotel Dieu Hospital, Kingston, Ontario, Canada K7L 3N6 Search for other works by this author on: This Site PubMed Google Scholar MERCEDES L. DE BOLD; MERCEDES L. DE BOLD †Departments of Pathology, Queen's University, Ontario, Canada K7L 3N6‡Hotel Dieu Hospital, Kingston, Ontario, Canada K7L 3N6 Search for other works by this author on: This Site PubMed Google Scholar P. L. DAVIES; P. L. DAVIES *Departments of Biochemistry, Ontario, Canada K7L 3N6 Search for other works by this author on: This Site PubMed Google Scholar BRIAN P. KENNEDY BRIAN P. KENNEDY *Departments of Biochemistry, Ontario, Canada K7L 3N6 Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1985) 13 (6): 1141. https://doi.org/10.1042/bst0131141 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation T. GEOFFREY FLYNN, ADOLFO J. DE BOLD, MERCEDES L. DE BOLD, P. L. DAVIES, BRIAN P. KENNEDY; Main forms of immunoreactive cardionatrin in atrial extracts and in atrial-specific granules. Biochem Soc Trans 1 December 1985; 13 (6): 1141. doi: https://doi.org/10.1042/bst0131141 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: TFA, trifluoroacetic acid This content is only available as a PDF. © 1985 Biochemical Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.
Core alignment technique based on image processing of warm fibers (1992)

The core alignment system (CAS) has been widely used in automatic optical fiber fusion splicers for many years. The fundamental principle of a AS splicer is the detection of the relative core positions of two fibers before fusion. The conventional method of core detection is based on the processing of a digital image taken by an installed video camera while the fibers are illuminated by a light source. Because of the circular cross-section of the fiber, the fiber works like a convex lens when the fiber is illuminated orthogonally to its axis. Thus, dark zones are generated in the focus plane along the boundaries of different refractive indices, such as the boundary between air and cladding as well as cladding and core.1,2 To resolve the very thin dark lines (~2 μm thick) along the core-cladding boundary, the lens should be placed close to the fiber to achieve rather high image magnification. But since the lens may get damaged by the high temperature of the arc, it has to be withdrawn during the fusion. This makes it impossible to monitor the warm fiber during the fusion with many automatic fusion splicers.
Protein biomarkers for amyotrophic lateral sclerosis (2008)

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with largely unknown pathogenesis that typically results in death within a few years from diagnosis. There are currently no effective therapies for ALS. Clinical diagnosis usually takes several months to complete and the long delay between symptom onset and diagnosis limits the possibilities for effective intervention and clinical trials. The establishment of protein biomarkers for ALS may aid an earlier diagnosis, facilitating the search for effective therapeutic interventions and monitoring drug efficacy during clinical trials. Biomarkers could also be used to discriminate between subtypes of ALS, to measure disease progression and to detect susceptibility for developing ALS or monitor adverse effects of drug treatment. The present review will discuss the opportunities and proteomic platforms used for biomarker discovery efforts in ALS, summarizing putative ALS protein biomarkers identified in different biofluids.
Coal-Gas-Burned High Efficiency Power Plant which Recovers Carbon Dioxide Generated (1990)

This paper describes a construction and a characteristics of a coal-gas-burned high efficiency power plant which emits no carbon dioxide (CO2) into the atmosphere. In a plant, CO2 gas and superheated steam are used as the main and the sub working fluid, respectively, of a closed dual fluid regenerative gas turbine power plant. Since coal gas composed of CO, H2, CO2 and CH4 is burnt in a combustor using oxygen, the exhaust gas led into a condenser includs only CO2 and H2O. Hence, CO2 gas can be easily separated at the condenser outlet from condensate. In the plant, the combustion gas is first used to generate power by driving a turbine. High-temperature turbine exhaust gas is next utilized at a regenerator to heat the main working fluid of CO2 gas flowing into the combustor, and then is utilized at a waste heat boiler to produce the superheated steam injected into the combustor. It is estimated that the power can be generated with gross thermal efficiency of 54.4%, and that the power generating efficiency is 46.7% which is calculated by subtracting the power required for producing the high-pressure oxygen used for combustion from the generator output. It is shown that the estimated efficiency is higher by 18.1 percentage points than that of a conventional boiler steam turbine power generating plant into which a process for removing and recovering CO2 from the stack gas by utilizing alkanolamine-based solvent is integrated.
Molten salt electrochemical systems for battery applications. [Patent: Al/AlCl/sub 3/--NaCl/S or I] (1976)

A molten salt electrochemical system for battery applications is provided comprising aluminum as the anode, positive oxidation states of either iodine or sulfur as the cathode, and a low-melting-point molten mixture of aluminum chloride and alkali chloride disposed between the anode and cathode and in contact with each.
Fabrication of Mechanically Strong Honeycombs with Aerogel Cores (2017)

Honeycomb aerogel composites were fabricated by reinforcing selected regions of a native aerogel matrix using photopolymerization. First, alcogels were synthesized by hydrolysis–condensation of a siloxane, and by adding a multifunctional acrylic monomer and a visible-light initiator to the gelation solution. Alcogels were then placed on a programmable translation stage and exposed to a laser. Polymerization and mechanical reinforcement were induced in the exposed regions. After exposure alcogels were dried supercritically. Thermal conductivity and out-of-plane modulus of the resulting honeycombs could be varied between values typical of native aerogels (11 mW/mK and 0.75 MPa) and those of uniformly polymerized composites (65.8 mW/mK and 36.26 MPa) by varying the translation stage speed between 2 and 3 mm/s. The results were interpreted using a rule-of-mixtures model. The mechanical properties of the composites were also investigated using finite element analysis.
A combination of directing groups and chiral anion phase-transfer catalysis for enantioselective fluorination of alkenes (2013)

We report a catalytic enantioselective electrophilic fluorination of alkenes to form tertiary and quaternary C(sp3)-F bonds and generate β-amino- and β-aryl-allylic fluorides. The reaction takes advantage of the ability of chiral phosphate anions to serve as solid-liquid phase transfer catalysts and hydrogen bond with directing groups on the substrate. A variety of heterocyclic, carbocyclic, and acyclic alkenes react with good to excellent yields and high enantioselectivities. Further, we demonstrate a one-pot, tandem dihalogenation-cyclization reaction, using the same catalytic system twice in series, with an analogous electrophilic brominating reagent in the second step.
Large-Scale Sentiment Analysis for News and Blogs (2007)

Newspapers and blogs express opinion of news entities (people, places, things) while reporting on recent events. We present a system that assigns scores indicating positive or negative opinion to each distinct entity in the text corpus. Our system consists of a sentiment identication phase, which associates expressed opinions with each relevant entity, and a sentiment aggregation and scoring phase, which scores each entity relative to others in the same class. Finally, we evaluate the signicance of our scoring techniques over large corpus of news and blogs.
Self Diagnostic Accelerometer Testing on the C-17 Aircraft (2013)

The self diagnostic accelerometer (SDA) developed by the NASA Glenn Research Center was tested for the first time in an aircraft engine environment as part of the Vehicle Integrated Propulsion Research (VIPR) program. The VIPR program includes testing multiple critical flight sensor technologies. One such sensor, the accelerometer, measures vibrations to detect faults in the engine. In order to rely upon the accelerometer, the health of the accelerometer must be ensured. The SDA is a sensor system designed to actively determine the accelerometer structural health and attachment condition, in addition to vibration measurements. The SDA uses a signal conditioning unit that sends an electrical chirp to the accelerometer and recognizes changes in the response due to changes in the accelerometer health and attachment condition. To demonstrate the SDAs flight worthiness and robustness, multiple SDAs were mounted and tested on a C-17 aircraft engine. The engine test conditions varied from engine off, to idle, to maximum power. The SDA attachment conditions were varied from fully tight to loose. The newly developed SDA health algorithm described herein uses cross correlation pattern recognition to discriminate a healthy from a faulty SDA. The VIPR test results demonstrate for the first.
Unlocking Fungal Cryptic Natural Products (2009)

Recent published sequencing of fungal genomes has revealed that these microorganisms have a surprisingly large number of secondary metabolite pathways that can serve as potential sources for new and useful natural products. Most of the secondary metabolites and their biosynthesis pathways are currently unknown, possibly because they are produced in very small amounts and are thus difficult to detect or are produced only under specific conditions. Elucidating these fungal metabolites will require new molecular genetic tools, better understanding of the regulation of secondary metabolism, and state of the art analytical methods. This review describes recent strategies to mine the cryptic natural products and their biosynthetic pathways in fungi.
Sequential Consistency for Heterogeneous-Race-Free: Programmer-centric Memory Models for Heterogeneous Platforms (2013)

Hardware vendors now provide heterogeneous platforms in commodity markets (e.g., integrated CPUs and GPUs), and are promising an integrated, shared memory address space for such platforms in future iterations. Because not all threads in a heterogeneous platform can communicate with the same latency, vendors are proposing synchronization mechanisms that allow threads to communicate with a subset of threads (called a scope). However, vendors have yet to define a comprehensive and portable memory model that programmers can use to reason about scopes. Moreover, existing CPU memory models, such as Sequential Consistency for Data-Race-Free (SC for DRF), are illsuited, in part, because they define all synchronization operations globally and preclude low-energy, highperformance local coordination. Towards this end, we embrace scoped synchronization with a new class of memory consistency models: Sequential Consistency for Heterogeneous-Race-Free (SC for HRF). Inspired by SC for DRF (C++, Java), the new models provide programmers with SC for programs with sufficient synchronization (no data races) of sufficient scope. We develop the first such model, called HRF0, show how it can be used to develop high-performance code, show example hardware support, and motivate future work.
Impedance Control Network Resonant dc-dc Converter for Wide-Range High-Efficiency Operation (2015)

This paper introduces a new resonant converter architecture that utilizes multiple inverters and a lossless impedance control network (ICN) to maintain zero-voltage switching and near zero-current switching across wide operating ranges. Hence, the ICN converter is able to operate at fixed frequency and maintain high efficiency across wide ranges in input and output voltages and output power. The ICN converter architecture enables increase in switching frequency (hence reducing size and mass), while achieving very high efficiency. Three prototype 200-W 500-kHz ICN resonant converters, one with low-Q, one with medium-Q, and one with high-Q resonant tanks, designed to operate over an input voltage range of 25 to 40 V and an output voltage range of 250 to 400 V are built and tested. The low-Q prototype ICN converter achieves a peak efficiency of 97.1%, maintains greater than 96.4% full power efficiency at 250 V output voltage across the nearly 2:1 input voltage range, and maintains full power efficiency above 95% across its full input and output voltage range. It also maintains efficiency above 94.6% over a 10:1 output power range across its full input and output voltage range owing to the use of burst-mode control.
Distortion-free optical transmission using time-domain optical Fourier transformation and transform-limited optical pulses (2005)

A method for distortion-free optical pulse transmission is theoretically proposed that employs optical Fourier transformation and Fourier transform-limited (TL) pulses. With this technique, a Fourier TL pulse is used as an input signal. By noting that a Gaussian TL pulse has a Gaussian spectrum, the unchanged spectrum of the TL pulse after transmission is converted into the time domain using optical Fourier transformation. Thus the transformed waveform in the time domain has no distortion as long as the transmitted spectral envelope is not changed owing to the perturbations.
<title>Computerized Detection Of Lung Nodules In Digital Chest Radiographs</title> (1987)

Detection of cancerous lung nodules in chest radiographs is one of the more important tasks performed by a radiologist. In addition, the "miss rate" associated with the radiographic detection of lung nodules is approximately 30%. A computerized scheme that alerts the radiologist to possible locations of lung nodules should allow this number of false-negative diagnoses to be reduced. We are developing a computer-aided nodule detection scheme based on a difference image approach. We attempt to eliminate the camouflaging background structure of the normal lung anatomy by creating, from a single-projection chest image, two images: one in which the signal-to-noise ratio (SNR) of the nodule is maximized and another in which that SNR is suppressed while the processed background remains essentially the same. Thus, the difference between these two processed images should consist of the nodule superimposed on a relatively uniform background in which the detection task may be simplified. This difference image approach is fundamentally different from conventional subtraction techniques (e.g., temporal or dual-energy subtraction) in that the two images which are subtracted arise from the same single-projection chest radiograph. Once the difference image is obtained, thresholding is performed along with tests for circularity, size and growth in order to extract the nodules. It should be noted that once an original chest image is input to the computer the nodule detection process is totally automated.
ChemInform Abstract: CRYSTAL STRUCTURE AND STRUCTURE‐RELATED PROPERTIES OF ZSM‐5 (1981)

Abstract An einem frisch dargestellten Zeolith ZSM‐5 (Si/Al = 86), der in der Raumgruppe Pnma kristallisiert, wird eine Röntgen‐Einkristallanalyse durchgeführt.
A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1). (1990)

The integrins are a family of heterodimeric cell surface receptors for extracellular matrix molecules. An analysis of integrin subunits expressed by a number of cell lines identified a novel heterodimer. The alpha subunit of this integrin was immunologically and electrophoretically indistinguishable from the vitronectin receptor alpha subunit (alpha v) and the beta subunit was indistinguishable from beta 1. Affinity chromatography experiments and cell adhesion assays indicated that this receptor complex is a new fibronectin receptor. Its unexpected subunit composition demonstrates the importance of the beta subunit in determining the ligand specificity of integrins and suggests that the current integrin classification scheme needs revision.
Doubling the near-infrared photocurrent in a solar cell via\n omni-resonant coherent perfect absorption (2019)

Minimizing the material usage in thin-film solar cells can reduce\nmanufacturing costs and enable mechanically flexible implementations, but\nconcomitantly diminishes optical absorption. Coherent optical effects can help\nalleviate this inevitable drawback at discrete frequencies. For example,\ncoherent perfect absorption guarantees that light is fully absorbed in a thin\nlayer regardless of material or thickness but only on resonance. Here we show\nthat omni resonance delivers such coherent enhancement over a broad bandwidth\nby structuring the optical field to nullify the angular dispersion intrinsic to\nresonant structures. After embedding an amorphous-silicon thin film\nphotovoltaic cell in a planar cavity, pre conditioning the incident light using\nan alignment free optical arrangement severs the link between the resonant\nbandwidth and the cavity photon lifetime, thereby rendering the cavity omni\nresonant. Coherently enhanced near infrared absorption doubles the photocurrent\nover the targeted spectral range 660 to 740 nm where every wavelength\nresonates. These results may pave the way to transparent solar cells that\noptimally harvest near infrared light.\n
Sustainable Earthquake Resilience with the Versatile Shape Memory Alloy (SMA)-Based Superelasticity-Assisted Slider (2022)

Earthquakes threaten humanity globally in complex ways that mainly include various socioeconomic consequences of life and property losses. Resilience against seismic risks is of high importance in the modern world and needs to be sustainable. Sustainable earthquake resilience (SER) from the perspective of structural engineering means equipping the built environment with appropriate aseismic systems. Shape memory alloys (SMAs) are a class of advanced materials well suited for fulfilling the SER demand of the built environment. This article explores how this capability can be realized by the innovative SMA-based superelasticity-assisted slider (SSS), recently proposed for next-generation seismic protection of structures. The versatility of SSS is first discussed as a critical advantage for an effective SER. Alternative configurations and implementation styles of the system are presented, and other advantageous features of this high-tech isolation system (IS) are studied. Results of shaking table experiments, focused on investigating the expected usefulness of SSS for seismic protection in hospitals and conducted at the structural earthquake engineering laboratory of the University of Bonab, are then reported. SSS is compared with currently used ISs, and it is shown that SSS provides the required SER for the built environments and outperforms other ISs by benefitting from the pioneered utilization of SMAs in a novel approach.
Advances in Diamond Integration for Thermal Management in GaN Power HEMTs (2014)

GaN high electron mobility transistors (HEMTs) performance is limited by self-heating during high power operation. Topside nanocrystalline diamond (NCD) layers have been integrated on AlGaN/GaN (HEMTs) to improve thermal management, exhibiting a 20%. decrease in peak channel temperature compared to reference HEMTs in a scalable process. Processing improvements, such as eliminating the SiN x passivation interlayer and developing a sacrificial gate process are being actively pursued. Also, boron doped p+-NCD films were implemented as gate electrodes for the AlGaN/GaN HEMT for a thermally stable heat-spreading gate contact.
Cosulfation of fatty acid alkanolamides and lower molecular weight alcohols (1977)

Abstract and Summary The process for the sulfation of tallow isopropanolamide or of a 50:50 mixture of tallow diglycolamide and isopropanolamide with chlorosulfonic acid was studied. The major obstacle to complete and uniform sulfation was the high viscosity of the sulfation mix. This could be overcome most advantageously by cosulfation with lower molecular weight alcohols, preferably isopropanol. The most fluid reaction mix and product were prepared from the mixed amides. No chlorinated solvent is required for such cosulfations.
High power, commercial Silicon-Film/sup TM/ solar cells (1996)

Silicon-Film/sup TM/ wafers are cut from continuous sheets of solar cell quality silicon grown on low cost substrates. The original Silicon-Film/sup TM/ solar cells, the AP-225, were squares cut 15.4 cm on a side for an area of 236 cm/sup 2/. The 15.4 cm dimension was the largest width that could be cut from the sheet while maintaining reasonable uniformity. Improvements in process control provided the opportunity to cut wafers that are 17.8 cm on a side for an area of 316 cm/sup 2/. This larger area has led to a new solar cell, the AP-300, with a power of 3.5 W. This power is the highest available for any commercial polycrystalline silicon solar cell. Increased power, while maintaining the cost of handling a single unit, results in enhanced value in the final product. A unique gettering process that utilizes a front surface aluminum layer has been developed to enhance solar cell performance. Prior to the work presented here, this process had achieved a 2.82 W solar cell for an area of 239 cm/sup 2/. Present process development and optimization efforts are concentrated on fine-tuning the silicon growth process and improving post-growth processing techniques. Post-growth improvement of minority carrier lifetime is accomplished through external gettering and bulk defect passivation techniques. This paper presents the solar cell process development that led to the demonstration of a 3.5 W large area AP-300 solar cell.