gebhart/patrepeval huggingface dataset:
A new fabrication technique for directly coupled transmural cardiac electrodes (1988)

Many current attempts at electrophysiological elucidation of cardiac arrhythmia mechanisms have centered around activation sequence mapping. This is most commonly performed with polarized unipolar or bipolar metal electrodes, which, because of unstable direct current (DC) base-line potentials, necessitate alternating current (AC)-coupled amplification. An ideal nonpolarizable unipolar electrode offers unhindered exchange of charge allowing for stable DC recordings of biological electrical activity. In addition to activation information, DC unipolar recordings enable quantitation of systolic and diastolic potentials, other low-frequency phenomena of interest such as repolarization, as well as rapid recovery from such rapid extreme potential shifts such as defibrillation. Previous attempts to apply nonpolarizable electrodes to transmural cardiac investigations required complex wick electrode techniques to prevent mechanical movement of the fluid-metal interface when chlorided silver wire was used. We have developed a technique to fabricate miniature sintered Ag-AgCl electrodes that are mounted at various locations on a 20-gauge stainless steel needle permitting stable transmural DC unipolar electrogram recordings in vivo. The electrodes are low noise, rugged, sterilizable, and reusable and should prove useful in three-dimensional electrophysiological characterization of the heart.
Total Synthesis of a Partial Structure from Arabinogalactan and Its Application for Allergy Prevention (2020)

Arabinogalactan, a microheterogeneous polysaccharide occurring in plants, is known for its allergy-protective activity, which could potentially be used for preventive allergy treatment. New treatment options are highly desirable, especially in a preventive manner, due to the constant rise of atopic diseases worldwide. The structural origin of the allergy-protective activity of arabinogalactan is, however, still unclear and isolation of the polysaccharide is not feasible for pharmaceutical applications due to a variation of the activity of the natural product and contaminations with endotoxins. Therefore, a pentasaccharide partial structure was selected for total synthesis and subsequently coupled to a carrier protein to form a neoglycoconjugate. The allergy-protective activity of arabinogalactan could be reproduced with the partial structure in subsequent in vivo experiments. This is the first example of a successful simplification of arabinogalactan with a single partial structure while retaining its allergy-preventive potential.
Online generation of profile association rules (1998)

The results discussed in this paper are relevant to a large database consisting of consumer profile information together with behavioral (transaction) patterns. The focus of this paper is on the problem of onhne mining of profile association rules in this large database. The profile association rule problem is closely related to the quantitative association rule problem. We show how to use multidimensional indexing structures in order to perform the mining. The use of multidimensional indexing structures to perform profile mining provides considerable advantages in terms of the ability to perform very generic range based onhne queries.
Flip and Flop: A Molecular Determinant for AMPA Receptor Channel Opening (2009)

Alternative splicing in the extracellular ligand binding domain of the AMPA receptors generates two variants, i.e., flip and flop. The flop variant of the GluR2 AMPA receptor is known to desensitize faster than the flip counterpart, whereas the GluR1 flip and flop variants exhibit the same rate of desensitization. However, whether the alternative splicing affects the channel opening kinetic properties of these receptors is unknown. Using a laser-pulse photolysis technique, we have characterized the channel opening kinetic mechanism for the flip and flop channels of GluR1 and GluR2, respectively. We find that the flop variant of GluR2 opens the channel, following the binding of glutamate, with the same rate as the flip channel, but closes its channel more rapidly. The difference in the kinetic properties between the two receptor isoforms can be described by a model we proposed previously in which the channel closing rate, a measure of the stability of the open channel state, controls an apparent tendency of the channel to desensitize, most likely, through the closed channel state. Specifically, the flop sequence of GluR2 promotes the channel to close more rapidly and consequently to desensitize with a faster rate than the flip sequence. For GluR1, the alternative splicing does not seem to affect the channel opening kinetics, since the flip and flop variants of GluR1 have the same channel opening rate, and the same channel closing rate. As expected and indeed observed, the flop variant desensitizes with the same rate as the flip variant does. On the basis of these results, we hypothesize that the flip/flop sequence cassette of AMPA receptors, in a sequence-dependent manner, regulates the rate of the channel closing process, in the microsecond time domain, through which it further regulates the channel desensitization in the millisecond time region.
Evaluation of synergy between host and pathogen-directed therapies against intracellular Leishmania donovani (2019)

Visceral leishmaniasis (VL) is associated with treatment complications due to the continued growth of resistant parasites toward currently available pathogen-directed therapeutics. To limit the emergence and combat resistant parasites there is a need to develop new anti-leishmanial drugs and alternative treatment approaches, such as host-directed therapeutics (HDTs). Discovery of new anti-leishmanial drugs including HDTs requires suitable in vitro assay systems. Herein, we modified and evaluated a series of resazurin assays against different life-stages of the VL causing parasite, Leishmania donovani to identify novel HDTs. We further analyzed the synergy of combinatorial interactions between traditionally used pathogen-directed drugs and HDTs for clearance of intracellular L. donovani. The inhibitory concentration at 50% (IC<sub>50</sub>) of the five evaluated therapies [amphotericin B (AMB), miltefosine, paromomycin, DNER-4, and AR-12 (OSU-03012)] was determined against promastigotes, extracellular amastigotes, and intracellular amastigotes of L. donovani via a resazurin-based assay and compared to image-based microscopy. Using the resazurin-based assay, all evaluated therapies showed reproducible anti-leishmanial activity against the parasite's different life-stages. These results were consistent to the traditional image-based technique. The gold standard of therapy, AMB, showed the highest potency against intracellular L. donovani, and was further evaluated for combinatorial effects with the HDTs. Among the combinations analyzed, pathogen-directed AMB and host-directed AR-12 showed a synergistic reduction of intracellular L. donovani compared to individual treatments. The modified resazurin assay used in this study demonstrated a useful technique to measure new anti-leishmanial drugs against both intracellular and extracellular parasites. The synergistic interactions between pathogen-directed AMB and host-directed AR-12 showed a great promise to combat VL, with the potential to reduce the emergence of drug-resistant strains.
Immersion zone-plate-array lithography (2005)

An immersion scheme is used to improve resolution, exposure latitude, and depth-of-focus in zone-plate-array lithography (ZPAL). We believe this is the first implementation of an immersion scheme in a maskless lithography system. Replacing air with de-ionized water as the medium between the zone-plate array and the substrate effectively increases the system’s numerical aperture and consequently, enhances its patterning capabilities. The design and fabrication process of an immersion zone plate is described. Its behavior is then characterized through the experimental reconstruction of its point-spread function, and compared to the theoretical model. A wide variety of patterns were printed, demonstrating the improved lithographic performance of immersion ZPAL.
Electro-optic transceivers for terahertz-wave applications (2001)

Because of the reciprocal behavior of the optical rectification and the electro-optic effect in a nonlinear optical crystal, an electro-optic transceiver can alternately transmit pulsed electromagnetic radiation (optical rectification) and detect the return signal (electro-optic effect) in the same crystal. However, the optimal condition of the electro-optic transceiver may be very different from that of the spatially separated emitter and receiver. We present a detailed description of the crystal-orientation dependence of the electro-optic terahertz devices (transmitter, receiver, and transceiver). It is found that for a (110) zinc-blende electro-optical crystal, the efficiency of the electro-optic transceiver will be optimized when the angle between the polarization of the optical pump beam and the crystallographic z axis [0, 0, 1] is 26°. Meanwhile, for a (111) crystal, the angle between the optical beam and the crystallographic direction [-1, -1, 2] should be 23°. The experimental results from a (110) ZnTe transceiver verify theoretical calculations and demonstrate a direct way to optimize the working efficiency of an electro-optic terahertz transceiver.
Method for non-oxidative hydrogen (1987)

A method is described for non-oxidatively hydrogen reactivating a coked dewaxing catalyst comprising palladium, an inorganic oxide binder and a zeolite component having a constraint index ranging from about 1 to 12 and a silica to alumina molar ratio of at least about 12. The method comprises contacting the coked dewaxing catalyst with hydrogen at a hydrogen pressure less than about 7000 kPa (1000 psig), where maximum rate of coke removal from the catalyst is effected at less than 500/sup 0/C.
Kinetic Capillary Electrophoresis (KCE):  A Conceptual Platform for Kinetic Homogeneous Affinity Methods (2005)

We propose kinetic capillary electrophoresis (KCE) as a conceptual platform for the development of kinetic homogeneous affinity methods. KCE is defined as the CE separation of species that interact during electrophoresis. Depending on how the interaction is arranged, different KCE methods can be designed. All KCE methods are described by the same mathematics: the same system of partial differential equations with only initial and boundary conditions being different. Every qualitatively unique set of initial and boundary conditions defines a unique KCE method. Here, we (i) present the theoretical bases of KCE, (ii) define four new KCE methods, and (iii) propose a multimethod KCE toolbox as an integrated kinetic technique. Using the KCE toolbox, we were able to, for the first time, observe high-affinity (specific) and low-affinity (nonspecific) interactions within the same protein-ligand pair. The concept of KCE allows for the creation of an expanding toolset of powerful kinetic homogeneous affinity methods, which will find their applications in studies of biomolecular interactions, quantitative analyses, and selecting affinity probes and drug candidates from complex mixtures.
Programmable presence virtualization for next-generation context-based applications (2009)

Presence, broadly defined as an event publish-notification infrastructure for converged applications, has emerged as a key mechanism for collecting and disseminating context attributes for next-generation services in both enterprise and provider domains. Current presence-based solutions and products lack in the ability to a) support flexible user-defined queries over dynamic presence data and b) derive composite presence from multiple provider domains. Accordingly, current uses of context are limited to individual domains/organizations and do not provide a programmable mechanism for rapid creation of context-aware services. This paper describes a presence virtualization architecture, where a Virtualized Presence Server receives customizable queries from multiple presence clients, retrieves the necessary data from the base presence servers, applies the required virtualization logic and notifies the presence clients. To support both query expressiveness and computational efficiency, virtualization queries are structured to separately identify both the XSLT-based transformation primitives and the presence sources over which the transformation occurs. For improved scalability, the proposed architecture offloads the XSLT-related processing to a high-performance XML processing engine. We describe our current implementation and present performance results that attest to the promise of this virtualization approach.
A COUNTER CURRENT EXPERIMENT FOR THE SEPARATION OF TRIVALENT ACTINIDES AND LANTHANIDES BY THE SETFICS PROCESS (1998)

ABSTRACT The SETFICS process, a variation of TRUEX process, was developed for the recovery of Am and Cm from acidic waste solution and the separation of actinides (III) and light lanthanides. The process uses the general TRUEX solvent as the extracting reagent and a DTPA-sodium nitrate solution for selective stripping of actinides(III). The basic flow sheet is composed of four steps: extraction-scrubbing; acid stripping; actinide(III) stripping; and lanthanide stripping. To demonstrate the usefulness of the SETFICS process, a counter current experiment was conducted using a real TRUEX product solution. Americium and curium were successfully recovered with a solution of 0.05 M DTPA-4 M NaNO3 (pH 2.0). Although the actinide(III) product solution contained Sm and Eu, the decontamination factor of 144Ce/241Am was 72, and most of the light lanthanides, specifically La, Ce, Pr, Nd, were removed. At least 80 % of the lanthanides were separated from the Am and Cm end products. In order to minimize the acidity in the actinide(III) stripping step, the nitric acid which extracted with the trivalent metals was previously removed with a solution of 0.5 M NaNO3 (pH 2.0) in the "acid stripping" step.
A distributed control approach for heterogeneous linear multiagent systems (2019)

This paper considers an internal model-based distributed control approach to the cooperative output regulation problem of heterogeneous linear time-invariant multiagent systems over fixed directed communication graph topologies. First, a new definition of the linear cooperative output regulation problem is introduced in order to allow a broad class of functions to be tracked and rejected by a network of agents. Second, the solvability of this problem with three distributed control laws, namely dynamic state feedback, dynamic output feedback with local measurement and dynamic output feedback, is investigated by first considering a global condition and then providing an agent-wise local sufficient condition under standard assumptions. Finally, two numerical examples are provided to illustrate the selected contributions of this paper.
A review of mechanically reconfigurable antennas using smart material actuators (2011)

Mechanically reconfigurable antennas have the potential to provide a large range of antenna reconfiguration and to have a lower cost than other reconfigurable technologies. Solid state devices in the RF signal path can cause distortion and power limiting, but such issues can be averted by keeping them out of the direct RF signal path. In this paper, new smart material technologies, namely electro-active polymers and shape memory alloy actuators, are presented as potential candidates to implement mechanically reconfigurable antennas. A review of some proof-of-concept reconfigurable antenna prototypes using these technologies is presented, including the advantages and disadvantages for the antenna applications.
A Multilevel Domain Decomposition Algorithm for Fast Reprojection of Tomographic (2000)

A novel algorithm for fast computation of tomo- graphic image projections is presented. The method comprises a decomposition of an image into subimages followed by an aggre- gation of projections computed for the subimages. The multilevel domain decomposition algorithm is formulated as a recursive procedure. The computational cost of the proposed algorithm is comparable to that of FFT-based techniques while it appears to be more flexible than the latter. Numerical results demonstrate the effectiveness of the method.
Acylated Hydroxamates as Selective and Highly Potent Inhibitors of Dipeptidyl Peptidase I (2005)

The compounds 10–14 which are N-dipeptidyl derivatives of O-acyl hydroxamates proved to be potent, selective and irreversible inhibitors of DP I.
Closed-Loop Phase-Dependent Vibration Stimulation Improves Motor Imagery-Based Brain-Computer Interface Performance (2021)

The motor imagery (MI) paradigm has been wildly used in brain-computer interface (BCI), but the difficulties in performing imagery tasks limit its application. Mechanical vibration stimulus has been increasingly used to enhance the MI performance, but its improvement consistence is still under debate. To develop more effective vibration stimulus methods for consistently enhancing MI, this study proposes an EEG phase-dependent closed-loop mechanical vibration stimulation method. The subject's index finger of the non-dominant hand was given 4 different vibration stimulation conditions (i.e., continuous open-loop vibration stimulus, two different phase-dependent closed-loop vibration stimuli and no stimulus) when performing two tasks of imagining movement and rest of the index finger from his/her dominant hand. We compared MI performance and brain oscillatory patterns under different conditions to verify the effectiveness of this method. The subjects performed 80 trials of each type in a random order, and the average phase-lock value of closed-loop stimulus conditions was 0.71. It was found that the closed-loop vibration stimulus applied in the falling phase helped the subjects to produce stronger event-related desynchronization (ERD) and sustain longer. Moreover, the classification accuracy was improved by about 9% compared with MI without any vibration stimulation (<i>p</i> = 0.012, paired <i>t</i>-test). This method helps to modulate the mu rhythm and make subjects more concentrated on the imagery and without negative enhancement during rest tasks, ultimately improves MI-based BCI performance. Participants reported that the tactile fatigue under closed-loop stimulation conditions was significantly less than continuous stimulation. This novel method is an improvement to the traditional vibration stimulation enhancement research and helps to make stimulation more precise and efficient.
Tissue Inhibition of Angiotensin-Converting Enzyme Activity Stimulates Angiogenesis In Vivo (1999)

ACE inhibition with quinaprilat promotes angiogenesis in a rabbit model of hindlimb ischemia. Thus, nonsulfhydryl ACE inhibitors with high tissue affinity may be potentially useful for therapeutic angiogenesis in ischemic tissues. Moreover, previous evidence that ACE inhibition benefits patients with myocardial ischemia may be due in part to augmented collateral development.
Peripherally Induced Reconditioning of the Central Nervous System: A Proposed Mechanistic Theory for Sustained Relief of Chronic Pain with Percutaneous Peripheral Nerve Stimulation (2021)

Peripheral nerve stimulation (PNS) is an effective tool for the treatment of chronic pain, although its efficacy and utilization have previously been significantly limited by technology. In recent years, purpose-built percutaneous PNS devices have been developed to overcome the limitations of conventional permanently implanted neurostimulation devices. Recent clinical evidence suggests clinically significant and sustained reductions in pain can persist well beyond the PNS treatment period, outcomes that have not previously been observed with conventional permanently implanted neurostimulation devices. This narrative review summarizes mechanistic processes that contribute to chronic pain, and the potential mechanisms by which selective large diameter afferent fiber activation may reverse these changes to induce a prolonged reduction in pain. The interplay of these mechanisms, supported by data in chronic pain states that have been effectively treated with percutaneous PNS, will also be discussed in support of a new theory of pain management in neuromodulation: Peripherally Induced Reconditioning of the Central Nervous System (CNS).
Ultrasonic networking for E-health applications (2013)

Wirelessly networked systems of intra-body sensors and actuators could enable revolutionary applications at the intersection between biomedical science, networking, and control with a strong potential to advance medical treatment of major diseases of our times. Yet, most research to date has focused on communications along the body surface among devices interconnected through traditional electromagnetic radio-frequency (RF) carrier waves; while the underlying root challenge of enabling networked intra-body miniaturized sensors and actuators that communicate through body tissues is substantially unaddressed. The main obstacle to enabling this vision of networked implantable devices is posed by the physical nature of propagation in the human body. The human body is composed primarily (65 percent) of water, a medium through which RF electromagnetic waves do not easily propagate, even at relatively low frequencies. Therefore, in this article we take a different perspective and propose to investigate and study the use of ultrasonic waves to wirelessly internetwork intra-body devices. We discuss the fundamentals of ultrasonic propagation in tissues, and explore important tradeoffs, including the choice of a transmission frequency, transmission power, and transducer size. Then, we discuss future research challenges for ultrasonic networking of intra-body devices at the physical, medium access and network layers of the protocol stack.
Spatiotemporal mode-locking: what it is, and different types (2018)

We describe, in general terms, what spatiotemporal mode-locking is and how it happens. Then we describe several recent new developments, including qualitatively distinct kinds of 3D pulses and mode-locking physics.