gebhart/patrepeval huggingface dataset:
Formyl peptide chemotactic receptor. Evidence for an active proteolytic fragment. (1983)

We have developed a radioiodinated photoaffinity label, N-formyl-Nle-Leu-Phe-Nle-125I-Tyr-Lys-N-6-(4'-azido-2'-nitrophenylamino) hexanoate (where Nle represents norleucine) (125I-PAL), which forms a covalent complex with the formyl peptide chemotactic receptor of living human neutrophils. Labeling was 12 to 16% efficient and did not alter cell viability. The receptor on live neutrophils and neutrophil membranes has an apparent molecular weight of 50,000 to 70,000 by sodium dodecyl sulfate-polyacrylamide electrophoresis. The receptor on intact cells possesses one predominant papain cleavage site, yielding a 35,000-Da fragment. This receptor fragment retains an affinity for N-formyl-Nle-Leu-Phe-Nle-125I-Tyr-Lys indistinguishable from the receptor on control cells (KD = 1.9 and 1.8 nM, respectively). The 35,000-Da papain fragment was biologically active as evidenced by an unchanged dose-response curve for peptide-stimulated beta-glucuronidase release and fluorescent peptide uptake. Papain treatment of 125I-PAL-labeled neutrophil membranes or of digitonin-soluble 125I-PAL-labeled receptors produced a predominant 28,000-Da fragment without evidence of the 35,000-Da fragment seen with whole cells. Pronase, which did not cleave the receptor on intact cells, produced multiple receptor fragments when used to treat 125I-PAL-labeled membranes.
Comparison of transfer ribonucleic acid structures using cobra venom and S1 endonucleases (1982)

Cobra venom nuclease V1, which cleaves double-stranded RNA, has been used to study the structure of four Escherichia coli tRNAs: Phe, Glu2, Leu2, and Ile1. The cleavage patterns are compared to those found for yeast tRNAPhe, the three-dimensional structure of which is known. The cleavage patterns of all the tRNA molecules are similar, and the most sensitive cleavage is found at the central base pair of the anticodon stem. Studies of E. coli tRNALeu2, which has a large variable loop, are consistent with the formation of a base-paired stem and loop structure that is not closely bound to the remainder of the molecule. A survey of the results suggests that the V1 molecule may interact with the minor groove of the double helix with an affinity for stacked bases and that it may require two or three stacked bases for optimal binding and cleavage.
Quantification of piscine reovirus (PRV) at different stages of Atlantic salmon Salmo salar production (2012)

The newly described piscine reovirus (PRV) appears to be associated with the development of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon Salmo salar L. PRV seems to be ubiquitous among fish in Norwegian salmon farms, but high viral loads and tissue distribution support a causal relationship between virus and disease. In order to improve understanding of the distribution of PRV in the salmon production line, we quantified PRV by using real-time PCR on heart samples collected at different points in the life cycle from pre-smolts to fish ready for slaughter. PRV positive pre-smolts were found in about 36% of the freshwater cohorts and a general increase in viral load was observed after their transfer to seawater. A reduction in viral loads was recorded when fish approached slaughter (18 mo in sea cages). Sequencing of positive samples did not support the hypothesis that outbreaks are caused by the spreading of a particular (virulent) strain of PRV.
Electrochromic switching with nanocrystalline TiO2 semiconductor films modified with surface attached viologens (1995)

Viologens adsorbed on TiO2 surfaces in nanocryst.-nanoporous electrodes were studied with regards to the electrochromic effect. The transparent nature and the high internal surface area of these electrodes are very beneficial in this regard. Absorbance up to 1 and coloration efficiencies >100 cm2C-1 were obtained. The switching times for these electrodes for both coloration and bleaching were faster than 1s, using 0.5M LiClO4 in MeCN as electrolyte. Preliminary stability tests were performed. For one of these electrodes the authors went through 654 cycles of coloration and bleaching without a decline in the coloration efficiency.
Joint time-frequency analysis (1999)

It has been well understood that a given signal can be represented in an infinite number of different ways. Different signal representations can be used for different applications. For example, signals obtained from most engineering applications are usually functions of time. But when studying or designing the system, we often like to study signals and systems in the frequency domain. Although the frequency content of the majority of signals in the real world evolves over time, the classical power spectrum does not reveal such important information. In order to overcome this problem, many alternatives, such as the Gabor (1946) expansion, wavelets, and time-dependent spectra, have been developed and widely studied. In contrast to the classical time and frequency analysis, we name these new techniques joint time-frequency analysis. We introduce the basic concepts and well-tested algorithms for joint time-frequency analysis. Analogous to the classical Fourier analysis, we roughly partition this article into two parts: the linear (e.g., short-time Fourier transform, Gabor expansion) and the quadratic transforms (e.g., Wigner-Ville (1932, 1948) distribution). Finally, we introduce the so-called model-based (or parametric) time-frequency analysis method.
<i>Helicobacter pylori</i> antibiotic resistance in Portugal: Systematic review and meta‐analysis (2018)

Hp resistance to the most widely used antibiotics is high in Portugal. Accordingly, our results suggest that the best therapeutic strategy for Hp in Portugal may be quadruple therapy with bismuth for adults and triple therapy including AMX plus MTZ or bismuth-based therapy for children.
An active adapter with edge cache approach for order status information integration (2004)

Sharing information among multiple business operations and distributed locations in an integrated manner has always been one of the central issues in business activity and process management. The effectiveness of the entire commerce value chain for an enterprise is largely dependent on the satisfaction of the information requesters. Improving upon the typical data federation approach, we propose to add data caches in the adapters that connect directly to the information requesters for fast data retrieval. To demonstrate the proposed approach, we have implemented the new active features for the IBM Websphere Business Integration middleware. Experimental results show that the active adapter approach significantly reduces the average data access time under a real order status tracking system.
Heterocyclic substituted ureas. I. Immunosuppression and virus inhibition by benzimidazolylureas (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeterocyclic substituted ureas. I. Immunosuppression and virus inhibition by benzimidazolylureasCharles J. Paget, Kiem Kisner, Robert Louis Stone, and Donald C. DeLongCite this: J. Med. Chem. 1969, 12, 6, 1010–1015Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://pubs.acs.org/doi/10.1021/jm00306a010https://doi.org/10.1021/jm00306a010research-articleACS PublicationsRequest reuse permissionsArticle Views227Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Hydrothermal Preparation and Characterization of Nanocrystalline Silver Gallium Sulfides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Large Batch Training of Convolutional Networks (2017)

A common way to speed up training of large convolutional networks is to add computational units. Training is then performed using data-parallel synchronous Stochastic Gradient Descent (SGD) with mini-batch divided between computational units. With an increase in the number of nodes, the batch size grows. But training with large batch size often results in the lower model accuracy. We argue that the current recipe for large batch training (linear learning rate scaling with warm-up) is not general enough and training may diverge. To overcome this optimization difficulties we propose a new training algorithm based on Layer-wise Adaptive Rate Scaling (LARS). Using LARS, we scaled Alexnet up to a batch size of 8K, and Resnet-50 to a batch size of 32K without loss in accuracy.
Depth of field multiplexing in microscopy (2010)

We demonstrate "depth of field multiplexing" by a high resolution spatial light modulator (SLM) in a Fourier plane in the imaging path of a standard microscope. This approach provides simultaneous imaging of different focal planes in a sample with only a single camera exposure. The phase mask on the SLM corresponds to a set of superposed multi-focal off-axis Fresnel lenses, which sharply image different focal planes of the object to non-overlapping adjacent sections of the camera chip. Depth of field multiplexing allows to record motion in a three dimensional sample volume in real-time, which is exemplarily demonstrated for cytoplasmic streaming in plant cells and rapidly swimming protozoa.
Sex Disparities in Cancer Mortality and Survival (2011)

Future analytic studies should attempt to understand causes of observed sex disparities in cancer.
Manufacturing and Characterization of 18Ni Marage 300 Lattice Components by Selective Laser Melting (2013)

The spreading use of cellular structures brings the need to speed up manufacturing processes without deteriorating mechanical properties. By using Selective Laser Melting (SLM) to produce cellular structures, the designer has total freedom in defining part geometry and manufacturing is simplified. The paper investigates the suitability of Selective Laser Melting for manufacturing steel cellular lattice structures with characteristic dimensions in the micrometer range. Alternative lattice topologies including reinforcing bars in the vertical direction also are considered. The selected lattice structure topology is shown to be superior over other lattice structure designs considered in literature. Compression tests are carried out in order to evaluate mechanical strength of lattice strut specimens made via SLM. Compressive behavior of samples also is simulated by finite element analysis and numerical results are compared with experimental data in order to assess the constitutive behavior of the lattice structure designs considered in this study. Experimental data show that it is possible to build samples of relative density in the 0.2456-0.4367 range. Compressive strength changes almost linearly with respect to relative density, which in turns depends linearly on the number of vertical reinforces. Specific strength increases with cell and strut edge size. Numerical simulations confirm the plastic nature of the instability phenomena that leads the cellular structures to collapse under compression loading.
Poxvirus Protein N1L Targets the I-κB Kinase Complex, Inhibits Signaling to NF-κB by the Tumor Necrosis Factor Superfamily of Receptors, and Inhibits NF-κB and IRF3 Signaling by Toll-like Receptors (2004)

Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit intracellular signaling by members of the IL-1 receptor (IL-1R) and Toll-like receptor (TLR) family. In vivo, the TLRs mediate the innate immune response by serving as pathogen recognition receptors, whose oligomerized intracellular Toll/IL-1 receptor (TIR) domains can initiate innate immune signaling. A family of TIR domain-containing adapter molecules transduces signals from engaged receptors that ultimately activate NF-kappaB and/or interferon regulatory factor 3 (IRF3) to induce pro-inflammatory cytokines. Data base searches detected a significant similarity between the N1L protein of vaccinia virus and A52R, a poxvirus inhibitor of TIR signaling. Compared with other poxvirus virulence factors, the poxvirus N1L protein strongly affects virulence in vivo; however, the precise target of N1L was previously unknown. Here we show that N1L suppresses NF-kappaB activation following engagement of Toll/IL-1 receptors, tumor necrosis factor receptors, and lymphotoxin receptors. N1L inhibited receptor-, adapter-, TRAF-, and IKK-alpha and IKK-beta-dependent signaling to NF-kappaB. N1L associated with several components of the multisubunit I-kappaB kinase complex, most strongly associating with the kinase, TANK-binding kinase 1 (TBK1). Together these findings are consistent with the hypothesis that N1L disrupts signaling to NF-kappaB by Toll/IL-1Rs and TNF superfamily receptors by targeting the IKK complex for inhibition. Furthermore, N1L inhibited IRF3 signaling, which is also regulated by TBK1. These studies define a role for N1L as an immunomodulator of innate immunity by targeting components of NF-kappaB and IRF3 signaling pathways.
Biomolecular Basis for Insecticide Resistance (1992)

Insecticide resistance, documented in nearly all arthropod species in which it has been studied, is a major obstacle to control of agriculturally and medically important pests. This book presents recent major breakthroughs in understanding, at the molecular level, the mechanisms by which insects acquire resistance to natural, synthetic or bioengineered insecticides. This chapter will summarize these advances, especially as they relate to the classification and comparative aspects of resistance mechanisms. Biochemodiversity, particularly in cytochrome P450s, is evident for resistance development among different insect species. Multiresistance involving target sites can be overcome with novel-acting chemistry or insecticides that do not allosterically interact with insensitive domains. Future implementation of transgenically or exogenously introduced insecticides will depend on our knowledge of the molecular dynamics of insecticide resistance.
Strongly Dipolar Bose-Einstein Condensate of Dysprosium (2011)

We report the Bose-Einstein condensation (BEC) of the most magnetic element, dysprosium. The Dy BEC is the first for an open f-shell lanthanide (rare-earth) element and is produced via forced evaporation in a crossed optical dipole trap loaded by an unusual, blue-detuned and spin-polarized narrowline magneto-optical trap. Nearly pure condensates of 1.5 × 10(4) (164)Dy atoms form below T = 30 nK. We observe that stable BEC formation depends on the relative angle of a small polarizing magnetic field to the axis of the oblate trap, a property of trapped condensates only expected in the strongly dipolar regime. This regime was heretofore only attainable in Cr BECs via a Feshbach resonance accessed at a high-magnetic field.
Development of Corrosion Resistant Aluminum Heat Exchanger, Part 1: Development of New Aluminum Alloy Sheets for Sacrificial Anode (1986)

<div class="htmlview paragraph">The sacrificial anodic effect of Al-Zn alloy reduces markedly in aluminium heat exchanger as car air-conditioner manufactured by vacuum brazing conventionally used, as zinc elements preferentially evaporate in vacuum-heating. It was found that Al-Sn alloy had superior electrochemical characteristics than Al-Zn alloy (AA7072) as the sacrificial anodic material used in vacuum brzing.</div> <div class="htmlview paragraph">According to many experimental results, the new brazing sheet-fin with Al-Mn-Sn alloy core metal has been developed. This fin has favorable formability and prominent sacrificial anodic effect. Therefore, this fin is excellent material for car air-conditioner manufactured by vacuum brazing.</div>
Antitumor activities of harringtonine and homoharringtonine, cephalotaxus alkaloids which are active principles from plant by intraperitoneal and oral administration. (1982)

Antitumor activities of harringtonine(HA) and homoharringtonine(HO) both belong to cephalotaxus alkaloids were compared with those of vinca alkaloids, vincristine (VCR) and vinblastine (VLB). HA and HO had significant activities against P388 leukemia, L1210 leukemia and B16 melanoma by intraperitoneal injection comparable to VCR and VLB. The therapeutic index (LD10/ED50) of HA and HO in B16 melanoma system was 1.90 and 2.31, while those of VCR and VLB were 1.38 and less than 1.00, respectively. The oral administration of these cephalotaxus alkaloids evoked a significant antitumor activity but that of vinca alkaloids induced no activity against P388 and B16 melanoma. The efficacy of HO on various tumor systems was equal or greater than that of HA when comparison was made between these two cephalotaxus alkaloids. In contrast to VCR and VLB, HA and HO demonstrated moderate activity against P388/VCR, a subline of P388 resistant to vincristine. The intraperitoneal injection of VCR or VLB produced an increase in the mitotic index of P388 cells as compared with the control values, but HA or HO decreased it. HA and HO, cephalotaxus alkaloids are a new class of active compounds of plant origin which may differ from the vinca alkaloids in the mechanism of antitumor activity.
Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With Imatinib (2011)

In this study, CML-related deaths were uncommon in CML patients who were in CCyR 2 years after starting imatinib, and survival was not statistically significantly different from that of the general population.
Is Hole Transfer Involved in Metalloporphyrin-Catalyzed Epoxidation? [<i>J. Am. </i><i>Chem. Soc.</i> <b>1993</b>, <i>115</i>, 7653−7664]. (2003)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionIs Hole Transfer Involved in Metalloporphyrin-Catalyzed Epoxidation? [J. Am. Chem. Soc.1993, 115, 7653−7664].Taisun Kim, Gholam A. Mirafzal, Jianping Liu, and Nathan L. BauldCite this: J. Am. Chem. Soc. 2003, 125, 52, 16463Publication Date (Web):December 6, 2003Publication History Published online6 December 2003Published inissue 1 December 2003https://pubs.acs.org/doi/10.1021/ja0334659https://doi.org/10.1021/ja0334659correctionACS PublicationsCopyright © 2003 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views515Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (15 KB) Get e-Alertsclose Get e-Alerts
Decomposition of higher-order spectra for blind multiple-input deconvolution, pattern identification and separation (2019)

Like the ordinary power spectrum, higher-order spectra (HOS) describe signal properties that are invariant under translations in time. Unlike the power spectrum, HOS retain phase information from which details of the signal waveform can be recovered. Here we consider the problem of identifying multiple unknown transient waveforms which recur within an ensemble of records at mutually random delays. We develop a new technique for recovering filters from HOS whose performance in waveform detection approaches that of an optimal matched filter, requiring no prior information about the waveforms. Unlike previous techniques of signal identification through HOS, the method applies equally well to signals with deterministic and nondeterministic HOS. In the non-deterministic case, it yields an additive decomposition, introducing a new approach to the separation of component processes within non-Gaussian signals having non-deterministic higher moments. We show a close relationship to minimum-entropy blind deconvolution (MED), which the present technique improves upon by avoiding the need for numerical optimization, while requiring only numerically stable operations of time shift, element-wise multiplication and averaging, making it particularly suited for real-time applications. The application of HOS decomposition to real-world signals is demonstrated with blind denoising, detection and classification of normal and abnormal heartbeats in electrocardiograms.
Discussion of a statistical channel (1994)

This paper deals with a new type of covert channel problem that arose when we designed a multilevel secure computer (MLS) system, using a quasi-secure, asynchronous, communication device called the Pump. We call this new type of covert channel a statistical channel. It is our hope to get feedback from experts who work in the intersection of information theory and statistics.
Joint spectrum sensing and primary user localization for cognitive radio via compressed sensing (2010)

Radio spectrum has become a precious resource, and it has long been the dream of wireless communication engineers to maximize the utilization of the radio spectrum. Dynamic Spectrum Access (DSA) and Cognitive Radio (CR) have been considered promising to enhance the efficiency and utilization of the spectrum. In current overlay cognitive radio, spectrum sensing is first performed to detect the spectrum holes for the secondary user to harness. However, in a more sophisticated cognitive radio, the secondary user needs to detect more than just the existence of primary users and spectrum holes. For example, in a hybrid overlay/underlay cognitive radio, the secondary use needs to detect the transmission power and localization of the primary users as well. In this paper, we combine the spectrum sensing and primary user power/localization detection together, and propose to jointly detect not only the existence of primary users but the power and localization of them via compressed sensing. Simulation results including the miss detection probability (MDP), false alarm probability (FAP) and reconstruction probability (RP) confirm the effectiveness and robustness of the proposed method.