gebhart/patrepeval huggingface dataset:
EVA: Exploratory Learning with Virtual Companions Sharing Attention and Context (2016)

Exploratory Learning with Virtual Companions Sharing Attention and Context (EVA) is a concept for mediated teaching and learning that sits at the intersection of exploratory learning, telepresence, and attention awareness. The companion teacher is informed about the attentional state and environment of the learner, and can refer directly to this environment through marking or annotation. To the learner, the companion is virtual -- either human or automatic -- and, if human, either physically copresent or remote. The content and style of presentation are tailored to the learner's momentary level of interest or focus, and her attention can be guided to salient environmental elements (e.g. visual) in order to convey desired information. We define a design space for such systems, which applies to learning in Augmented Reality and Virtual Reality, and can be employed as a framework for design and evaluation. We demonstrate this through trials with two proof-of-concept systems, one in AR and one in VR, with a human companion. We conclude that the EVA design space defines a powerful set of systems for learning and finish by presenting guidelines for making such systems maximally effective.
Progress in Strip Casting Technologies for Steel; Technical Developments (2013)

The present article is a sequel to the previous review on the history of near net shape strip casting facilities. The present review focuses on technical progress made in strip casting over the last three decades. Strip casting is a revolutionary technology that promises the hope for an efficient, economical and environmentally-friendly process to produce hot-rolled, steel sheets. This review provides a summary of the theory, recent research, and progress, in the developments of strip casting operations for steels, along with technical discussions regarding the characteristics and design features of steel strip casting machines. Two strip casting processes are discussed in detail; the Twin-Roll Casting (TRC) process and the Horizontal Single-Belt Casting (HSBC) process. Particular emphasis is placed on topics such as the commercial potential for strip casting technology in the steel industry, and the economic and environmental advantages of direct strip production, versus current continuous casting, fixed mold technologies.
Cooperativity among Molecules at Interfaces in Relation to Various Technological Processes:  Effect of Chain Length on the p<i>K</i><sub>a</sub> of Fatty Acid Salt Solutions (1999)

The orientation of surface-active molecules at interfaces is extremely important in determining the dynamic and equilibrium properties of such systems. Films of fatty acid salts were studied at various pH values of the solutions. It was found that there exists a pH where minimum evaporation of water, maximum foamability, maximum foam stability, minimum contact angle on PMMA surface, maximum single-bubble stability, and maximum surface viscosity are observed. It was also found that this optimum pH value is near the pKa of the fatty acid salts. The experimental results are explained in terms of area per molecule, intermolecular spacing, and cooperativity among soap molecules at the interface. It was further shown that the chain length of the soap molecules can modulate the area per molecule, and hence the intermolecular distance in the film, and thereby influence the ionization behavior of the fatty acid carboxyl group. The pKa increases from 6.5 to about 9.0 as the chain length of the fatty acid salt increases from C8 to C16. Cooperativity among surfactant molecules at the interface is controlled by the area per molecule and intermolecular spacing in the adsorbed film. A small change in intermolecular distance of 0.03 Å can significantly influence various technological processes such as foaming, emulsification, wetting, and retardation of evaporation.
Sex differences in the association between obesity and hypertension (2021)

The pathogenesis of obesity-related hypertension in women differs from that in men and tends to be associated with metabolic disorders.
Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes. (1994)

The sulfation of the adrenal steroid dehydroepiandrosterone (DHEA) is a critical step in the provision of substrates for estrogen biosynthesis by the placenta during pregnancy. This enzyme reaction is catalyzed by a cytosolic sulfotransferase (ST) found in many key body tissues, and we have examined the ontogeny and localization of expression of this important enzyme in three tissues: the liver, adrenal, and kidney. Hepatic DHEA ST expression increased with advancing gestational age before reaching near-adult levels in the early postnatal period, suggesting an increased requirement for this enzyme in the liver as development progresses, whereas in the adrenal and kidney there was no obvious ontogenic pattern. The enzyme was expressed at a 5-fold higher level in the adrenal than in the liver and some 40-fold higher than in the kidney. Comparison of enzyme activity measurements and quantitation of the expression of DHEA ST by immunodot blot analysis with an anti-DHEA ST antibody preparation demonstrated the fragility of the enzyme activity and suggested that immunoquantitation was a superior method for assessment of levels of expression of this enzyme in widely different tissue sources. Examination of the localization of DHEA ST in these tissues by immunohistochemistry showed that in liver, DHEA ST was expressed in embryonic hepatocytes and continued to be expressed in these cells into adulthood, when there was some concentration of immunostaining around central veins. In the fetus, the adrenal enzyme was expressed in the fetal zone, whereas in adult tissue, staining was localized principally to the zona reticularis. Renal DHEA ST was present in the proximal and distal tubules, loops of Henle, collecting ducts, and their progenitors, but was at no time expressed in the vascular glomerulus. In light of the broad substrate specificity of this enzyme toward other steroids, in particular bile acids and cholesterol, the information presented forms a strong basis for further studies into the role of DHEA ST in modulating the activity of a number of biologically active and potentially toxic steroids in the developing human.
Near-infrared broad-band cavity enhanced absorption spectroscopy using a superluminescent light emitting diode (2009)

A fibre coupled near-infrared superluminescent light emitting diode that emits approximately 10 mW of radiation between 1.62 and 1.7 microm is employed in combination with a broad-band cavity enhanced spectrometer consisting of a linear optical cavity with mirrors of reflectivity approximately 99.98% and either a dispersive near-infrared spectrometer or a Fourier transform interferometer. Results are presented on the absorption of 1,3-butadiene, and sensitivities are achieved of 6.1 x 10(-8) cm(-1) using the dispersive spectrometer in combination with phase-sensitive detection, and 1.5 x 10(-8) cm(-1) using the Fourier transform interferometer (expressed as a minimum detectable absorption coefficient) over several minutes of acquisition time.
Expressed sequence tag (EST) analysis of two subspecies of Metarhizium anisopliae reveals a plethora of secreted proteins with potential activity in insect hosts (2003)

Expressed sequence tag (EST) libraries for Metarhizium anisopliae, the causative agent of green muscardine disease, were developed from the broad host-range pathogen Metarhizium anisopliae sf. anisopliae and the specific grasshopper pathogen, M. anisopliae sf. acridum. Approximately 1,700 5' end sequences from each subspecies were generated from cDNA libraries representing fungi grown under conditions that maximize secretion of cuticle-degrading enzymes. Both subspecies had ESTs for virtually all pathogenicity-related genes cloned to date from M. anisopliae, but many novel genes encoding potential virulence factors were also tagged. Enzymes with potential targets in the insect host included proteases, chitinases, phospholipases, lipases, esterases, phosphatases and enzymes producing toxic secondary metabolites. A diverse array of proteases composed 36 % of all M. anisopliae sf. anisopliae ESTs. Eighty percent of the ESTs that could be clustered into functional groups had significant matches (E<10(-5)) in other ascomycete fungi. These included genes reported to have specific roles in pathogens with plant or vertebrate hosts. Many of the remaining ESTs had their best BLAST match among animal, plant and bacterial sequences. These include genes with plant and microbial counterparts that produce potent antimicrobials. The abundance of transcripts discovered for different functional groups varied between the two subspecies of M. anisopliae in a manner consistent with ecological adaptations of the two pathogens. By hastening gene discovery this project has enhanced development of improved mycoinsecticides. In addition, the M. anisopliae ESTs represent a significant contribution to the extensive database of sequences from ascomycetes that are saprophytes or plant and vertebrate pathogens. Comparative analyses of these sequences is providing important information about the biology and evolutionary history of this clade.
Does low‐energy collision‐induced dissociation of lithiated and sodiated carbohydrates always occur at anomeric carbon of the reducing end? (2017)

Rationale Collision‐induced dissociation (CID) tandem mass spectrometry is one of the major methods in the structural determination of carbohydrates. Previous experimental studies and theoretical investigation of lithiated and sodiated underivatized carbohydrates seem to indicate that dehydration reactions and cross‐ring dissociation of low‐energy CID mainly occur at the anomeric carbon of the reducing end. However, these studies only investigated a few carbohydrates. Methods ESI‐MS/MS spectra of [M + Li] + and [M + Na] + ions of several 18 O1‐labeled monosaccharides and disaccharides at O1 of the reducing end were studied using a linear ion trap mass spectrometer. Results Dissociations from the losses of both labeled and unlabeled neutral fragments were observed. The branching ratios of dissociations from the losses of unlabeled neutrals for dehydration reactions are larger than that for cross‐ring dissociation; lithiated carbohydrates are larger than sodiated carbohydrates, and 1‐4 linkages of disaccharides are larger than the other linkages. For some lithiated carbohydrates, dehydration reactions from the losses of unlabeled neutrals have larger branching ratios than that from the losses of labeled neutrals. The fragments from the losses of unlabeled neutrals investigated using MS 3 showed that the losses of unlabeled H 2 O mainly occur at the reducing monomer for sodiated carbohydrates, but the losses of unlabeled C 2 H 4 O 2 for lithiated carbohydrates can occur at both reducing and nonreducing monomers. The ratio of B 1 and Y 1 ions to C 1 and Z 1 ions of disaccharides is related to the cis or trans configuration of the O1 and O2 atoms in the nonreducing monomer. The results are explained by the properties of transition states of dissociation channels. Conclusions Our data shows that dehydration reactions and cross ring dissociation do not always occur at the anomeric carbon atom of the reducing monomer.
Safe Blues: The case for virtual safe virus spread in the long-term fight against epidemics (2021)

Viral spread is a complicated function of biological properties, the environment, preventative measures such as sanitation and masks, and the rate at which individuals come within physical proximity. It is these last two elements that governments can control through social-distancing directives. However, infection measurements are almost always delayed, making real-time estimation nearly impossible. Safe Blues is one way of addressing the problem caused by this time lag via online measurements combined with machine learning methods that exploit the relationship between counts of multiple forms of the Safe Blues strands and the progress of the actual epidemic. The Safe Blues protocols and techniques have been developed together with an experimental minimal viable product, presented as an app on Android devices with a server backend. Following initial exploration via simulation experiments, we are now preparing for a university-wide experiment of Safe Blues.
Diverse actions of cadmium on the smooth muscle myosin phosphorylation system (1990)

The effects of cadmium (Cd) on smooth muscle myosin phosphorylation have been investigated using an in vitro system comprising myosin filaments containing endogenous calmodulin (CM) and myosin light chain kinase (MLCKase). In the absence of calcium (Ca), Cd as well as some other divalent cations caused no activation of phosphorylation. However, when at least one (or possibly two) Ca2+ were bound per CM, the addition of 10 microM to 40 microM Cd2+ resulted in a 2 to 3 fold acceleration of the phosphorylation rate. Higher Cd concentrations caused inhibition of the system independent of Ca2+ concentration through the formation of Cd-ATP complexes. These results explain some previously controversial data on the complex effects of Cd in intact smooth muscles.
Forecasting Pseudo Random Numbers Using Deep Learning (2021)

Software algorithms are incapable of generating truly random numbers. Algorithmic pseudo random number generators (PRNG’s) are used instead. Any pure randomness, like initiating a random seed, requires a query external to the PRNG algorithm. Is it possible for deep learning to mimic the performance of a PRNG algorithm using a generated string of numbers for training? There are at least two approaches to doing this. In the first, a class of parameterized PRNG’s is assumed a priori and learning consists of identification the PRNG parameters. The second approach is nonparametric and makes no model assumption. It seeks to forecast subsequent pseudo random numbers learned solely from a string of numbers generated by the PRNG. Our approach closely resembles the latter. We show that learning the sequence of a variation of the linear congruential generator random number generator to a good approximation is possible using neural network deep learning.
Dysthyroid Orbitopathy (2000)

Dysthyroid orbitopathy (DO) is an autoimmune disorder usually associated with Graves' disease. The extra-ocular muscles are the target of the autoimmune attack. As a result, they become enlarged, producing restrictive ophthalmoplegia and proptosis. Other cardinal signs of DO include upper eyelid retraction and lag, conjunctival injection and chemosis, and periorbital edema. Visual loss may occur if the enlarged extra-ocular muscles compress the optic nerve in the orbital apex. These cardinal signs may mimic neurological conditions, including Parinaud's syndrome, sixth nerve palsy, carotid-cavernous fistula, and spheno-orbital meningioma. Treatment is directed at the cardinal signs and is largely palliative. Under certain clinical conditions, judicious use of corticosteroids, radiation therapy, or surgery designed to decompress the orbit, correct strabismus, or restore normal lid position may help to restore visual function.
Soft Rasterizer: A Differentiable Renderer for Image-based 3D Reasoning (2019)

Rendering bridges the gap between 2D vision and 3D scenes by simulating the physical process of image formation. By inverting such renderer, one can think of a learning approach to infer 3D information from 2D images. However, standard graphics renderers involve a fundamental discretization step called rasterization, which prevents the rendering process to be differentiable, hence able to be learned. Unlike the state-of-the-art differentiable renderers, which only approximate the rendering gradient in the back propagation, we propose a truly differentiable rendering framework that is able to (1) directly render colorized mesh using differentiable functions and (2) back-propagate efficient supervision signals to mesh vertices and their attributes from various forms of image representations, including silhouette, shading and color images. The key to our framework is a novel formulation that views rendering as an aggregation function that fuses the probabilistic contributions of all mesh triangles with respect to the rendered pixels. Such formulation enables our framework to flow gradients to the occluded and far-range vertices, which cannot be achieved by the previous state-of-the-arts. We show that by using the proposed renderer, one can achieve significant improvement in 3D unsupervised single-view reconstruction both qualitatively and quantitatively. Experiments also demonstrate that our approach is able to handle the challenging tasks in image-based shape fitting, which remain nontrivial to existing differentiable renderers.
An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition (2011)

This model is able to integrate differential fitness effects on various cell types, allowing us to simultaneously capture effects on interacting cell types without having to perform separate experiments. This model system may be used to screen for new classes of cancer prevention agents designed to modulate the competition between normal and neoplastic cells.
Effectiveness of cognitive analytic therapy for personality disorders (2013)

Personality disorders affect up to 50% of psychiatric out-patients. Most treatment studies have been performed in patients with borderline personality disorder. Structured psychosocial interventions for people with borderline personality disorders appear to have similar efficacy. There is some evidence that non-structured, non-specialised treatments offered by psychiatric general services might be ineffective and possibly harmful in patients with personality disorders. Cognitive analytic therapy is a time-limited, integrative psychotherapy, which appears to be effective for a range of personality disorders and superior to treatment as usual. Its practical nature and relatively short time limit may make it suitable for front-line clinical services.
Closing One of the Last Gaps in Polyionene Compositions: Alkyloxyethylammonium Ionenes as Fast‐Acting Biocides (2011)

Alkyloxyethylammonium ionenes are reported as biocompatible biocides with a time of biocidal action within a few minutes. The presence of both ethoxyethyl and aliphatic spacers besides long alkyl chain substituents on the quaternary nitrogen atom differentiates these biocides structurally from the known polyionenes. The influence of alkyl spacer length, counter ion and length of the pendant alkyl groups on the antibacterial properties is studied. E. coli is adopted as a test organism. MIC and MBC values are determined via broth dilution methods; time-dependent tests are accomplished by determining the number of viable cells with the spread-plate method after different contact times. Structural characterization is conducted via NMR and mass spectrometry techniques.
Effect of Gd‐DTPA‐BMA on blood and myocardial T<sub>1</sub> at 1.5T and 3T in humans (2006)

T(1) is significantly longer for myocardium (but not blood) at 3T compared to 1.5T. The differences in T(1) due to field strength are reduced following contrast administration, which may be attributed to changes in DeltaR(1myo)/DeltaR(1blood) with field strength.
Corneal Biomechanical Metrics in Eyes With Refraction of −19.00 to +9.00 D in Healthy Brazilian Patients (2008)

Corneal biomechanical metrics of healthy Brazilian patients were associated with CCT, gender, and age. Corneal steepness, ACD, and spherical equivalent refraction did not affect comeal hysteresis and CRF values in the studied population.
A re-evaluation of the risk factors for the recurrence of primary sclerosing cholangitis in liver allografts (2009)

Previously, we have found that the absence of the colon after liver transplantation (LT) protects the patient from recurrent primary sclerosing cholangitis (rPSC). As our previous observation has not been confirmed in other series, we have reviewed our cohort of patients grafted for primary sclerosing cholangitis (PSC) with greater numbers and longer follow-up to reassess the rate, consequences, and risk factors for rPSC. We collected data on patients who underwent LT for PSC between January 1986 and April 2006. Data were collected for cytomegalovirus status, inflammatory bowel disease status, time of colectomy, type of colectomy, donor-recipient gender mismatch, recipient sex, extended donor criteria (EDC), and donor risk index. Accepted criteria were used to diagnose rPSC. Of a total of 230 consecutive adult patients, 61 (27%) underwent colectomy pre-/peri-LT, and 54 (23.5%) developed rPSC at a median of 4.6 (range, 0.5-12.9) years post-LT. A total of 263 deceased donor grafts were used, and 73 were EDC grafts. A diagnosis of rPSC was made in 61 of the 263 grafts (23%). The recurrence-free patient survival was significantly better (P < 0.05) in patients who underwent pre-/peri-LT colectomy and in those with non-EDC grafts. In conclusion, in this larger cohort of 230 patients and with longer follow-up of 82.5 (range, 0.0-238.6) months [in comparison with the previous report of 152 recipients with a follow-up of 52.8 (range, 1-146) months], we have shown that colectomy remains a significant risk factor for rPSC and that colectomy before and during initial LT for PSC confers a protective effect against rPSC in subsequent graft(s). Moreover, we have shown that EDC grafts are also a significant risk factor for rPSC.
Surface-enhanced Raman scattering on periodic metal nanotips with tunable sharpness (2009)

This paper reports on a scalable bottom-up technology for producing periodic gold nanotips with tunable sharpness as surface-enhanced Raman scattering (SERS) substrates. Inverted silicon pyramidal pits, which are templated from non-close-packed colloidal crystals prepared by a spin-coating technology, are used as structural templates to replicate arrays of polymer nanopyramids with nanoscale sharp tips. The deposition of a thin layer of gold on the polymer nanopyramids leads to the formation of SERS-active substrates with a high enhancement factor (up to 10(8)). The thickness of the deposited metal determines the sharpness of the nanotips and the resulting Raman enhancement factor. Finite-element electromagnetic modeling shows that the nanotips can significantly enhance the local electromagnetic field and the sharpness of nanotips greatly affects the SERS enhancement.