gebhart/patrepeval huggingface dataset:
Myb-lnduced Transformation (1996)

The c-myb protooncogene has been implicated in the development of avian and murine hematopoietic neoplasms of the myeloid and lymphoid lineages. The transcription factor encoded by this gene has a dual function in oncogenesis because it regulates genes that prevent apoptosis and genes involved in cellular proliferation. c-myb has repeatedly been a target of retroviral insertional mutagenesis. The most common mechanism by which retroviruses activate c-myb's oncogenic potential is by providing transcriptional control that results in constitutive expression, a feature that is consistent with the demonstration that ectopic expression of c-myb can prevent growth arrest of differentiating hematopoietic cells. In a less common mechanism of activation, carboxyl(C)-terminal truncation renders the c-Myb protein more stable and active in transcriptional transactivation. Interestingly, the ability of v-Myb, a product of the avian myeloblastosis virus (AMV), to cause rapid transformation of cells in vivo and in vitro can be explained by the combined effects of deregulated expression through the retroviral LTR, N- and C-terminal truncation, and activating mutations in its DNA binding domain. Although c-myb's involvement in human leukemia has been suggested, it has never been clearly established and should be investigated further.
The antioxidant activity of amino acids in two vegetable oils (1983)

Abstract Of 27 amino acids studied, most had some antioxidant activity when added in aqueous solution to either safflower oil or a mixture of sunflower and cottonseed oil (active oxygen and storage methods). Cysteine‐HCl, glutamic acid‐HCl (in the mixture), and glutamic acid‐HCl (in safflower oil) behaved as prooxidants. When added as a solid, most amino acids were ineffective. The protection factors of these amino acids were less than 1.3 in safflower oil with methionine, proline, lysine and cysteine providing the highest activ‐ity. In the oil mixture (which had a higher metal content) lysine, arginine, glutamic acid, methionine, and hydroxyproline were anti‐oxidant with protection factors of up to 1.85. Chelation of metals by amino acids was presumably responsible for the antioxidant activity. The increase in cysteine concentration up to 1% has more than doubled the protection factor in Bint oil (compared with the 0.01% level), whereas with some other amino acids the increase was either small or slight.
Impact of Nonischemic Scar Features on Local Ventricular Electrograms and Scar-Related Ventricular Tachycardia Circuits in Patients With Nonischemic Cardiomyopathy (2013)

Electrogram features are associated with scar morphology and distribution in patients with nonischemic cardiomyopathy. Previous knowledge of electrogram image associations may optimize procedural strategies including the decision to obtain epicardial access.
Scalable Privacy-Compliant Virality Prediction on Twitter (2018)

The digital town hall of Twitter becomes a preferred medium of communication for individuals and organizations across the globe. Some of them reach audiences of millions, while others struggle to get noticed. Given the impact of social media, the question remains more relevant than ever: how to model the dynamics of attention in Twitter. Researchers around the world turn to machine learning to predict the most influential tweets and authors, navigating the volume, velocity, and variety of social big data, with many compromises. In this paper, we revisit content popularity prediction on Twitter. We argue that strict alignment of data acquisition, storage and analysis algorithms is necessary to avoid the common trade-offs between scalability, accuracy and privacy compliance. We propose a new framework for the rapid acquisition of large-scale datasets, high accuracy supervisory signal and multilanguage sentiment prediction while respecting every privacy request applicable. We then apply a novel gradient boosting framework to achieve state-of-the-art results in virality ranking, already before including tweet's visual or propagation features. Our Gradient Boosted Regression Tree is the first to offer explainable, strong ranking performance on benchmark datasets. Since the analysis focused on features available early, the model is immediately applicable to incoming tweets in 18 languages.
Culture of <i>Escherichia coli</i> under dissolved oxygen gradients simulated in a two‐compartment scale‐down system: Metabolic response and production of recombinant protein (2004)

A significant problem of large-scale cultures, but scarcely studied for recombinant E. coli, is the presence of gradients in dissolved oxygen tension (DOT). In this study, the effect of DOT gradients on the metabolic response of E. coli and production of recombinant pre-proinsulin, accumulated as inclusion bodies, was determined. DOT gradients were simulated in a two-compartment scale-down system consisting of two interconnected stirred-tank bioreactors, one maintained at anoxic conditions and the other at a DOT of at least 6%. Cells were continuously circulated between both vessels to simulate circulation times (tc) of 20, 50, 90, and 180 sec. A complete kinetic and stoichiometric characterization was performed in the scale-down system as well as in control cultures maintained at constant DOT in the range of 0-20%. The performance of E. coli cultured under oscillating DOT was significantly affected, even at a tc of 20 sec corresponding to transient exposures of only 13.3 sec to anaerobic conditions. Specific growth rate decreased linearly with tc to a maximum reduction of 30% at the highest tc tested. The negative effect of DOT gradients was even more pronounced for the overall biomass yield on glucose and the maximum concentration and yield of pre-proinsulin. In these cases, the losses were 9%, 27%, and 20%, respectively, at tc of 20 sec and 65%, 94%, and 87%, respectively, at tc of 180 sec. Acetic, lactic, formic, and succinic acids accumulated during oscillatory DOT cultures, indicating that deviation of carbon flow to anaerobic metabolism was responsible for the observed losses. The results of this study indicate that even very short exposures to anaerobic conditions, typical of large-scale operations, can substantially reduce recombinant protein productivity. The information presented here is useful for establishing improved rational scale-up strategies and understanding the behavior of recombinant E. coli exposed to DOT gradients.
Search for<sup>3</sup>He and<sup>4</sup>He in Arata-Style Palladium Cathodes I: A Negative Result (2001)

The 3He and 4He concentrations in 2- to 6-mg samples of palladium-black from the interior of Arata-style cathodes were investigated using a tungsten wire furnace on-line to an ultrahigh sensitivity static mass spectrometer. The detection limit of the mass spectrometer was ~104 atoms 3He and 108 atoms 4He, and the mass resolution of 1 part in 620 was sufficient to cleanly resolve 3He from H3 and HD. Three specimens of palladium-black (A, B, and C) were from hollow Pd cathodes that had generated excess heat in D2O electrolysis experiments carried out by Arata and Zhang in their laboratory. One specimen of Pd-black (D) had not been used in any electrolysis experiment. A total of twelve samples, three from each specimen, were analyzed. The 3He and 4He concentrations were variable as if due to sample inhomogeneity. Two samples (C-1 and B-1) showed apparent 4He of 4.4 × 109 atoms/mg and 6.6 × 109 atoms/mg, respectively, and three (A-3, B-2, and D-3) showed excess 3He from 77 to 1096 × 103 atoms/mg relative to the atmospheric 3He/4He ratio. Seven samples showed no apparent excess of 3He or 4He. Five samples of the aluminum foil used to wrap Pd-black samples were also analyzed and gave mean values of 13 ± 18 × 103 atoms/mg and 1.50 ± 0.66 × 109 atoms/mg for 3He and 4He, respectively. The values for Al and Pd-black are comparable to the 1978 results of Mamyrin, Khabarin, and Yudenich, who examined helium isotopes in many ordinary metals and other materials including Al and Pd. At present, there is no evidence for the very much larger concentrations (1016 to 1017 atoms/mg) of 3He and 4He that Arata and Zhang claim to have detected in similar specimens of Pd-black from Pd cathodes subjected to D2O electrolysis.
Rho GTPase signaling complexes in cell migration and invasion (2017)

Cell migration is dependent on the dynamic formation and disassembly of actin filament-based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as well as on cell-cell and cell-extracellular matrix adhesions. These processes all involve Rho family small guanosine triphosphatases (GTPases), which are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Rho GTPase activity needs to be precisely tuned at distinct cellular locations to enable cells to move in response to different environments and stimuli. In this review, we focus on the ability of RhoGEFs and RhoGAPs to form complexes with diverse binding partners, and describe how this influences their ability to control localized GTPase activity in the context of migration and invasion.
Chemotrap-1: An Engineered Soluble Receptor That Blocks Chemokine-Induced Migration of Metastatic Cancer Cells<i>In vivo</i> (2010)

Cancer and dendritic cells recognize and migrate toward chemokines secreted from lymphatics and use this mechanism to invade the lymphatic system, and cancer cells metastasize through it. The lymphatic-secreted chemokine ligand CCL21 has been identified as a key regulatory molecule in the switch to a metastatic phenotype in melanoma and breast cancer cells. However, it is not known whether CCL21 inhibition is a potential therapeutic strategy for inhibition of metastasis. Here, we describe an engineered CCL21-soluble inhibitor, Chemotrap-1, which inhibits migration of metastatic melanoma cells in vivo. Two-hybrid, pull-down, and coimmunoprecipitation assays allowed us to identify a naturally occurring human zinc finger protein with CCL21 chemokine-binding properties. Further analyses revealed a short peptide (∼70 amino acids), with a predicted coiled-coil structure, which is sufficient for association with CCL21. This CCL21 chemokine-binding peptide was then fused to the Fc region of human IgG1 to generate Chemotrap-1, a human chemokine-binding Fc fusion protein. Surface plasmon resonance and chemotaxis assays showed that Chemotrap-1 binds CCL21 and inhibits CCL21-induced migration of melanoma cells in vitro with subnanomolar affinity. In addition, Chemotrap-1 blocked migration of melanoma cells toward lymphatic endothelial cells in vitro and in vivo. Finally, Chemotrap-1 strongly reduced lymphatic invasion, tracking, and metastasis of CCR7-expressing melanoma cells in vivo. Together, these results show that CCL21 chemokine inhibition by Chemotrap-1 is a potential therapeutic strategy for metastasis and provide further support for the hypothesis that lymphatic-mediated metastasis is a chemokine-dependent process.
Estimating scattering attenuation from vugs or karsts (2003)

Abstract Cavities in carbonate rock, such as vugs or karsts, cause scattering attenuation in passing waves. The degree of such attenuation is often difficult to quantify because the exact scale and structure of the cavities is unknown. Taking the exact vug structure from X-ray computerized-tomography scans of two carbonate cores, we use 3D finite-difference modeling to determine the P-wave scattering attenuation in these cores at ultrasonic frequencies. The predicted scattering attenuation is quite high, with Q of 15 and 8 near the source frequency of 250 kHz. In spite of the sharp contrast in medium properties between cavity and rock, and the violation of the small perturbation assumption, the computed scattering attenuation is roughly comparable to that predicted by various random medium scattering theories. This suggests that if the volume fraction and typical size of vugs or karsts can be estimated, then a rough estimate of frequency-dependent scattering attenuation can be made.
Mickie Bhatia: Embryonic stem cells come of age (2009)

Mickie Bhatia wants to tap into the therapeutic potential of human stem cells, and he's finding ways to overcome the obstacles that stand in his way.
Thickness monitoring of graphene on SiC using low-energy electron diffraction (2010)

The formation of epitaxial graphene on SiC is monitored in situ using low-energy electron diffraction (LEED). The possibility of using LEED as an in situ thickness monitor of the graphene is examined. The ratio of primary diffraction spot intensities for graphene compared to SiC is measured for a series of samples of known graphene thickness (determined using low-energy electron microscopy). It is found that this ratio is effective for determining graphene thicknesses in the range of 1–3 ML. Effects of a distribution of graphene thicknesses on this method of thickness determination are considered.
Call control in the AMSC Mobile Satellite Service system (1994)

The characteristics of a mobile satellite communications system lead to a set of control requirements which are significantly different from those to be found in a terrestrial system. This paper presents the signaling and communication channel architecture as well as the processes and procedures which have been implemented to provide call control in the American Mobile Satellite Corporation's (AMSC's) Mobile Telephone Service offering. These designs have been optimized to take full advantage of the attributes of the satellite system and to satisfy its unique requirements. A combination of dedicated random access, time division multiplex, and time division multiple access channels, as well as inband signaling in the single channel per carrier (SCPC) communication links, are used to achieve the necessary performance. Efficiency and robustness are of particular importance. A variety of specialized protocols and signaling units designed in conjunction with the channel architecture have also been implemented. The designs, design tradeoffs, anticipated performance, and pertinent examples are presented.
New Technology to Evaluate Equivalent Circulating Density While Drilling Using Artificial Intelligence (2018)

Abstract The equivalent circulation density (ECD) is a very important parameter in drilling high pressure high temperature (HPHT) wells and deep water wells. In formations where the margins between the formation pore pressure (PP) and the formation fracture pressure (FP) is narrow, ECD is a key parameter. In these critical operations, the ECD is used to control the formation pressure and prevent kicks. The recent approaches in oilfield depend mainly on using expensive downhole sensors for providing real time values of ECD. These tools also have operational limits which may prevent using it in all downhole conditions. The objective of this paper is to present a new technique for predicting ECD values while drilling without the need for downhole tools. The technique uses surface drilling parameters in a model to evaluate the ECD values precisely using artificial intelligence (AI) techniques. The model was developed using two AI techniques; artificial neural network (ANN) and adaptive neuro fuzzy inference system (ANFIS). Using this technique will save cost and time by eliminating needs for using expensive, complicated downhole tools like measurement while drilling (MWDs) and pressure while drilling (PWD). The results obtained showed that the accuracy of the developed model is very high with error factor less than 0.22 % comparing the actual to predicted ECD values. Implementing this model in well design will have great impact in accurately choosing correct mud weights to safely drill the well. It will also minimize the drilling problems related to ECD such as losses or gains especially in critical area where margins between pore and fracture pressure is very narrow.
Light-Responsive Polyelectrolyte/Gold Nanoparticle Microcapsules (2005)

We report the preparation and characterization of light-responsive delivery vehicles, microcapsules composed of multiple polyelectrolyte layers and light-absorbing gold nanoparticles. The nanostructured capsules were loaded with macromolecules (fluorescein isothiocyanate-labeled dextran) by exploiting the pH-dependence of the shell permeability, and the encapsulated material was released on demand upon irradiation with short (10 ns) laser pulses in the near-infrared (1064 nm). In addition, the polyelectrolyte multilayer shell was modified with lipids (dilauroylphosphatidylethanolamine) and then functionalized with ligands (monoclonal immunoglobulin G antibodies) for the purposes of enhanced stability and targeted delivery, respectively. We anticipate that these capsules will find application in a range of areas where controlled delivery is desirable.
Fast Motion Estimation Method Based on Motion Vector Differences (2011)

본 논문은 움직임벡터차의 확률을 이용하여 움직임 탐색 범위를 결정하는 새로운 고속 움직임 추정 방법을 제안한다. 제안된 방법은 일종의 적응적 탐색영역 방법이다. 움직임벡터차의 분포에 대한 조사하고 그 분포의 파라미터를 최대우도추정방법으로 추정한다. 이 추정된 분포를 이용하여 탐색 범위는 움직임벡터차의 지정된 확률에 의해 효과적으로 제한될 수 있음을 보인다. 실험적으로 제안된 방법의 성능이 화질면에서 전역탐색법과 유사하며 복잡도 면에서는 중대한 감소를 입증하였다. 뿐만 아니라, 제안된 방법이 기존의 적응적 탐색영역 방법에 비해 훨씬 더 효과적으로 탐색영역을 결정함을 보여주었다. This paper presents a new fast motion estimation method where search ranges are determined by the probabilities of motion vector differences (MVDs), which is an adaptive/dynamic search range (ASR) method. The MVDs' distribution is investigated and its parameter is estimated by the maximum likelihood estimator. With the estimated distribution, we show that the search ranges can be efficiently restricted by a prefixed probability for MVDs. Experimental results showed that the performance of the proposed method is very similar to that of the full search algorithm in PSNR but it enables significant reduction in the computational complexity. In addition, they revealed that the proposed method determine the search ranges much more efficiently than the conventional ASR methods.
Peranan Penyuluh Agama Islam Non Pns dalam Meningkatkan Motivasi Ibadah Majelis Taklim Al Kahfi Mandar Salurihan (2021)

Islam adalah agama dakwah yang mewajibkan pengikutnya berdakwah sesuai dengan kemampuannya. Pembina Islam merupakan bagian dari pelaksanaan dakwah (dakwah) pembinaan kehidupan beragama umat dan pengemban dakwah pembangunan dengan pendekatan religius kepada masyarakat. Oleh karena itu, Pembimbing Agama Islam memainkan peran yang sangat penting dan strategis dalam mewujudkan masyarakat yang religius, sejahtera, dan bahagia. Ia berperan sebagai pemimpin dalam urusan agama, sosial dan kenegaraan untuk targetnya, agen dan motivator perubahan sosial, fasitator bahkan katalis pengembangan masyarakat.
Structure-activity studies of novel D-Ser8-cyclosporine A derivatives as potential anti-HIV drugs (2002)

A symposium report. Since the discovery of the immunosuppressive activity of cyclosporine A (CsA), considerable work has been devoted to the chem. synthesis of potent analogs. More recently, the finding of potential anti-HIV I activity of CsA raised interest for the design of CsA-derived compds. devoid of immunosuppressive activity. With this objective, the highly immunosuppressive CsA analog DSer8CsA was taken as a versatile candidate for modulating the binding mode to its receptors cyclophilin A (CypA) and calcineurin A (CnA). To this end, the functional group at position 8 of 1 is used for the chemoselective transformation to substituted pseudoproline systems and to dimers disposing variable linkers. Direct-transformation of a serine or threonine to a pseudoproline (PPro) has been shown to be a valuable method to tune the activity of bioactive compds.. Here the authors applied this strategy to DSer8CsA using various monosubstituted dimethoxyacetals in the presence of pyridium p-toluenesulfonate. In vitro activities of cyclosporin derivs. were evaluated applying the IL-2 reporter gene assay (measuring immunosuppressive activity) and the binding affinity to CypA (related to the anti-HIV activity). In conclusion, SAR studies of DSer8CsA derivs. applying the PPro concept and dimerization techniques at position 8 reveal differential effects on receptor binding, resulting in compds. of high therapeutical interest. [on SciFinder (R)]
Charge injection at carbon nanotube-SiO2 interface (2008)

Most single-wall carbon nanotube field-effect transistors show significant hysteresis in their transfer characteristics between forward and reverse gate bias sweeps. It was proposed that the hysteresis is due to a dynamic charging process at the carbon nanotube-dielectric interface. We have studied the charge injection and subsequent discharging processes at the carbon nanotube-SiO2 interface using electrostatic force microscopy. It was observed that the water layer assists charge diffusion on the dielectric surface.
Highly nonlinear dispersion-flattened photonic crystal fibers for supercontinuum generation in a telecommunication window (2004)

We propose a new structure of highly nonlinear dispersion-flattened (HNDF) photonic crystal fiber (PCF) with nonlinear coefficient as large as 30 W(-1)km(-1) at 1.55 microm designed by varying the diameters of the air-hole rings along the fiber radius. This innovative HNDF-PCF has a unique effective-index profile that can offer not only a large nonlinear coefficient but also flat dispersion slope and low leakage losses. It is shown through numerical results that the novel microstructured optical fiber with small normal group-velocity dispersion and nearly zero dispersion slope offers the possibility of efficient supercontinuum generation in the telecommunication window using a few ps pulses.
Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes (2008)

Liposome-based chemical exchange saturation transfer (lipoCEST) agents have shown great sensitivity and potential for molecular magnetic resonance imaging (MRI). Here we demonstrate that the size of liposomes can be exploited to enhance the lipoCEST contrast. A concise analytical model is developed to describe the contrast dependence on size for an ensemble of liposomes. The model attributes the increased lipoCEST contrast in smaller liposomes to their larger surface-to-volume ratio, causing an increased membrane water exchange rate. Experimentally measured rates correlate with size, in agreement with the model. The water permeability of liposomal membrane is found to be 1.11 +/- 0.14 microm/s for the specific lipid composition at 22 degrees C. Availability of the model allows rational design of the size of liposomes and quantification of their properties. These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties.
On the channel-length dependence of the hot-carrier degradation of n-channel MOSFETs (1989)

The channel-length dependence of lifetime plots is analyzed. It is shown that no unique tau *I/sub d/ versus I/sub sub//I/sub d/ relation can be obtained when threshold-voltage shifts are used for measuring the lifetime. In contrast, when using charge pumping as a monitor for the degradation, the lifetime plot for a given technology proves to be independent of the channel length.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>