gebhart/patrepeval huggingface dataset:
Mechanism of the Inhibitory Effect of OPB-9195 [(±)-2-Isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide] on Advanced Glycation End Product and Advanced Lipoxidation End Product Formation (2000)

The accumulation in uremic plasma of reactive carbonyl compounds (RCO) derived from both carbohydrates and lipids ("carbonyl stress") contributes to uremic toxicity by accelerating the advanced glycation and lipoxidation of proteins. It was previously demonstrated that OPB-9195 [(+/-)-2-isopropylidenehydrazono-4-oxo- thiazolidin-5-ylacetanilide] inhibited the in vitro formation of advanced glycation end products (AGE) in uremic plasma. This study was designed to elucidate the mechanism of action of OPB-9195 by further delineating the AGE and advanced lipoxidation end product (ALE) precursors targeted by this drug. The inhibitory effects of OPB-9195 on the formation of two AGE (N:epsilon-carboxymethyllysine and pentosidine) on bovine serum albumin incubated with various AGE precursors were examined. Inhibition of N:epsilon-carboxymethyllysine and pentosidine formation with OPB-9195 was more efficient than with aminoguanidine. OPB-9195 also proved effective in blocking the carbonyl amine chemical processes involved in the formation of two ALE (malondialdehyde-lysine and 4-hydroxynonenal-protein adduct). The efficiency of OPB-9195 was similar to that of aminoguanidine. When glucose-based peritoneal dialysis fluid was incubated in the presence of OPB-9195, a similar inhibition of AGE formation was observed. The direct effect of OPB-9195 on major glucose-derived RCO in peritoneal dialysis fluids was then evaluated. The effects of OPB-9195 could be accounted for by its ability to trap RCO. The concentrations of three major glucose-derived RCO (glyoxal, methylglyoxal, and 3-deoxy-glucosone) were significantly lower in the presence of OPB-9195 than in its absence. Aminoguanidine had a similar effect. In conclusion, OPB-9195 inhibits both AGE and ALE formation, probably through its ability to trap RCO. OPB-9195 might prove to be a useful tool to inhibit some of the effects of RCO-related uremic toxicity.
Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients (1997)

This study confirms that acamprosate could be an interesting adjuvant for maintaining abstinence in detoxified alcoholics.
Proteinase‐alpha<sub>2</sub> macroglobulin complexes are not increased in plasma of patients with cancer (1991)

Alpha 2-macroglobulin, a major glycoprotein component of plasma, is unique in its capacity to bind and inhibit the proteolytic activities of all classes of proteinases. Since proteinases implicated in cancer dissemination (type-IV collagenase, plasminogen activator, cathepsins B) are normal constitutents of blood, we have explored the hypothesis that elevated tissue levels of activated proteinases bound to alpha 2M might be detected in plasma of patients with cancer. To test this premise, blood was collected from 149 subjects (33 healthy controls, 31 patients with infections and non-malignant diseases, 16 with myeloproliferative disease, 10 with gastrointestinal cancer, 7 with genito-urinary cancer, 16 with lung cancer, 14 with lymphoma, 11 with miscellaneous cancers and 11 with chronic lymphocytic leukemia and myeloma). Plasma was assayed for alpha 2M-proteinase complexes using a sandwich ELISA which employs a mouse monoclonal antibody (MAb) that binds to a neo-antigenic determinant on complexed alpha 2M and a rabbit polyclonal anti-native human alpha 2M antibody. The concentration of complexed alpha 2M in healthy controls was 14.2 +/- 9.8 micrograms/ml (mean +/- standard deviation). No significant differences in complexed alpha 2M were noted between normal and cancer groups (range 7.4-14.6 micrograms/ml). On the basis of these data, we propose that, in patients with cancer, activated proteinases are bound locally to inhibitors in the tissues and are not available to form complexes with plasma alpha 2M. An alternative explanation is that proteinases are not secreted in excess by cancer cells in vivo.
FAN1 modifies Huntington’s disease progression by stabilizing the expanded <i>HTT</i> CAG repeat (2018)

Huntington's disease (HD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half of the variation in age at onset (AAO) but genetic variation elsewhere in the genome accounts for a significant proportion of the remainder. Genome-wide association studies have identified a bidirectional signal on chromosome 15, likely underlain by FANCD2- and FANCI-associated nuclease 1 (FAN1), a nuclease involved in DNA interstrand cross link repair. Here we show that increased FAN1 expression is significantly associated with delayed AAO and slower progression of HD, suggesting FAN1 is protective in the context of an expanded HTT CAG repeat. FAN1 overexpression in human cells reduces CAG repeat expansion in exogenously expressed mutant HTT exon 1, and in patient-derived stem cells and differentiated medium spiny neurons, FAN1 knockdown increases CAG repeat expansion. The stabilizing effects are FAN1 concentration and CAG repeat length-dependent. We show that FAN1 binds to the expanded HTT CAG repeat DNA and its nuclease activity is not required for protection against CAG repeat expansion. These data shed new mechanistic insights into how the genetic modifiers of HD act to alter disease progression and show that FAN1 affects somatic expansion of the CAG repeat through a nuclease-independent mechanism. This provides new avenues for therapeutic interventions in HD and potentially other triplet repeat disorders.
Thermotropic ionic liquid crystals by molecular assembly and ion pairing of 4,4′-bipyridinium derivatives and tris(dodecyloxy)benzenesulfonates in a non-polar solvent (2012)

The present work reports a simple and versatile pathway to incorporate redox-active 4,4′-bipyridinium (“viologen”) units with two, three, or six charges into dynamically ordered liquid crystalline structures by ionic interactions. A detailed analysis of the structure–property relationship was supported by molecular modelling experiments. Three redox-active 4,4′-bipyridinium (“viologen”) cores, 1,1′-dimethyl (4-pyridin-4-ylpyridinium) di- (MV2+2+2+2+), 1,1′,1′′-[benzene-1,3,5-triyltris(methylene)]tris(4-pyridin-4-ylpyridinium) tri- (V3+3+3+3+3+), and 1,1′,1′′-[benzene-1,3,5-triyltris(methylene)]tris[(methyl) 4-pyridin-4-ylpyridinium] hexa- (MV6+6+6+) cationic halides, were combined with an anionic caesium 3,4,5-tris(dodecyloxy)benzene sulfonate (DOBS) under phase transfer conditions to yield complexes of constant stoichiometry. The formed complexes, MV2+2+2+(DOBS)222, V3+3+3+(DOBS)333 and MV6+6+6+(DOBS)666, were characterized by NMR spectroscopy. Depending on the molecular structure, significantly different characteristics in electrochemical behaviour of ionic liquid crystals (ILCs) with two DOBS anions and a rod-like core (MV2+2+2+2+) were observed compared with ILs with three and six DOBS anions and y-shaped cores (V3+3+3+3+3+), and (MV6+6+6+) cations respectively. We report for the first time a new electroactive thermotropic liquid crystal, MV2+2+2+(DOBS)222, which changes colour from yellow to blue-green above 75 °C typically for redox units in the reduced state. The reduced states of the MV2+2+2+(DOBS)222 complex at E = −2 V exhibit reversible redox waves and have influence on molecular arrangement in the crystal structure as seen by polarisation microscopy. Our ionic liquid crystals have potential applications, due to their low melting temperature, wide temperature range, ionic conductivity, and thermal- and electro-chromism, for instance, for the design of electrochromic displays.
Deform PF-MT: Particle Filter With Mode Tracker for Tracking Nonaffine Contour Deformations (2009)

We propose algorithms for tracking the boundary contour of a deforming object from an image sequence, when the nonaffine (local) deformation over consecutive frames is large and there is overlapping clutter, occlusions, low contrast, or outlier imagery. When the object is arbitrarily deforming, each, or at least most, contour points can move independently. Contour deformation then forms an infinite (in practice, very large), dimensional space. Direct application of particle filters (PF) for large dimensional problems is impractically expensive. However, in most real problems, at any given time, most of the contour deformation occurs in a small number of dimensions ("effective basis space") while the residual deformation in the rest of the state space ("residual space") is small. This property enables us to apply the particle filtering with mode tracking (PF-MT) idea that was proposed for such large dimensional problems in recent work. Since most contour deformation is low spatial frequency, we propose to use the space of deformation at a subsampled set of locations as the effective basis space. The resulting algorithm is called deform PF-MT. It requires significant modifications compared to the original PF-MT because the space of contours is a non-Euclidean infinite dimensional space.
Hepatoportal arteriovenous fistula treated with detachable balloon embolotherapy. (1989)

Hepatic artery to portal vain fistulas were first reported in 1892. Symptoms of portal hypertension usually occur within weeks to months, once the fistula develops. Various attempts at surgical occlusion and embolization, with varying results, have been reported. This report is of a 33-yr-old woman who, 23 yrs after an automobile accident, was admitted with ascites and diagnosed as having a right hepatic artery-to-portal vein fistula (RHAPVF), which was successfully occluded via detachable balloon embolic therapy. The ascites resolved within 3 days of the embolotherapy, and subsequent follow-up revealed no recurrence of ascites during the next 18 months.
The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus (2014)

The insulin-like growth factor (IGF) system, acting in concert with other hormone axes, is important in normal metabolism. In obesity, the hyperinsulinaemia that accompanies peripheral insulin resistance leads to reduced growth hormone (GH) secretion, while total IGF-I levels are relatively unchanged due to increased hepatic GH sensitivity. IGF-binding protein (IGFBP)-1 levels are suppressed in relation to the increase in insulin levels in obesity and low levels predict the development of type 2 diabetes several years later. Visceral adiposity and hepatic steatosis, along with a chronic inflammation, contribute to the IGF system phenotype in individuals with metabolic syndrome and type 2 diabetes mellitus, including changes in the normal inverse relationship between IGFBP-1 and insulin, with IGFBP-1 concentrations that are inappropriately normal or elevated. The IGF system is implicated in the vascular and other complications of these disorders and is therefore a potential therapeutic target.
Representation of 3-D mappings for automotive control applications using neural networks and fuzzy logic (2002)

Providing a simple and effective way to describe the nonlinear input-output behaviour of a system, three-dimensional mappings (3-D maps) have gained a lot of importance in modern automotive technology. Applications cover a wide range from real-time control systems up to the area of vehicle simulation. Replacing the conventional look-up-tables by neural network or fuzzy logic representations offers an easy possibility to generate 3-D maps by measured data and to adapt them online using measured signals. This paper describes the modelling of engine characteristics for vehicle control and simulation purposes by multilayer perceptron and radial-basis function networks. In addition to that, a neuro-fuzzy approach is discussed as well.
4-Channel Continuous-Time 77 GSa/s ADC using Photonic Bandwidth Compression (2007)

A four-channel continuous-time implementation of photonic bandwidth compression technique is reported. In our approach, which is based on the transient time-stretched analog-to-digital converter (ADC) technology, continuous high speed RF signals arc segmented in the time domain and multiplexed into an array of parallel channels. The segments in each channel are temporally stretched, or equivalently compressed in bandwidth, before digitization. Benefits of our technique include multiplying the effective sample rate and input bandwidth of an ADC. Segments from all 4-channels arc concatenated to form the continuous signal using an out-of-band real-time calibration tone to independently correct for gain and timing errors. In this paper, a 4-channel continuous-time architecture is demonstrated that increases the bandwidth and sampling rate of a state-of-the-art real-time 50 GSa/s digitizer by 55%. A 4-channel system is of particular interest because it matches the number of input channels available on commercial oscilloscopes. The results indicate a viable path to a 4-channel continuous-time system that would be capable of enhancing existing digitizers by more than 300% and achieving 150 GSa/s over 50 GHz in real-time.
Accurate Reactive Power Sharing in an Islanded Microgrid Using Adaptive Virtual Impedances (2014)

In this paper, a reactive power sharing strategy that employs communication and the virtual impedance concept is proposed to enhance the accuracy of reactive power sharing in an islanded microgrid. Communication is utilized to facilitate the tuning of adaptive virtual impedances in order to compensate for the mismatch in voltage drops across feeders. Once the virtual impedances are tuned for a given load operating point, the strategy will result in accurate reactive power sharing even if communication is disrupted. If the load changes while communication is unavailable, the sharing accuracy is reduced, but the proposed strategy will still outperform the conventional droop control method. In addition, the reactive power sharing accuracy based on the proposed strategy is immune to the time delay in the communication channel. The sensitivity of the tuned controller parameters to changes in the system operating point is also explored. The control strategy is straightforward to implement and does not require knowledge of the feeder impedances. The feasibility and effectiveness of the proposed strategy are validated using simulation and experimental results from a 2-kVA microgrid.
Mycorrhiza and root hairs in barley enhance acquisition of phosphorus and uranium from phosphate rock but mycorrhiza decreases root to shoot uranium transfer (2004)

Some phosphate rocks (PR) contain high concentrations of uranium (U), which are potentially toxic via accumulation in soils and food chains, and plant uptake of U is likely to be influenced by characteristics of roots and associated microorganisms. The relative importance of root hairs and mycorrhiza in U uptake from PR was studied using a root hairless barley (Hordeum vulgare) mutant (Brb) and its wild type (WT). Both plant genotypes were grown in pots with Glomus intraradices BEG 87, or in the absence of mycorrhiza, and three P treatments were included: nil P, 2% (w/w) PR and 50 mg KH(2)PO(4)-P kg(-1) soil. Mycorrhiza markedly increased d. wts and P contents of Brb amended with nil P or PR, but generally depressed d. wts of WT plants, irrespective of P amendments. Mycorrhiza had contrasting effects on U contents in roots and shoots, in particular in Brb where mycorrhiza increased root U concentrations but decreased U translocation from roots to shoots. The experiment supports our understanding of arbuscular mycorrhiza as being multifunctional by not only improving the utilization of PR by the host plant but also by contributing to the phytostabilization of uranium.
Highly sensitive electrochemical detection of methyl salicylate using electroactive gold nanoparticles (2013)

Electrochemical sensing of methyl salicylate, a key plant volatile has been achieved using a gold nanoparticle (AuNP) modified screen printed carbon electrode (SPCE). The electrochemical response of planar gold electrodes, SPCE and AuNP-SPCE in alkaline electrolyte in the presence and absence of methyl salicylate were studied to understand the amperometric response of various electrochemical reactions. The reaction mechanism includes hydrolysis of methyl salicylate and the oxidation of negative species. The electrochemical responses were recorded using cyclic voltammetry and differential pulse voltammetry techniques, where the results showed characteristic signals for methyl salicylate oxidation. Among the examined electrodes, AuNP-SPCE possessed three fold better sensitivity than planar gold and 35 times better sensitivity than SPCE (at 0.5 V). The methyl salicylate sensing by AuNP-SPCE possessed <5% variation coefficient for repeatability, one week of stable performance with no more than 15% activity loss even if used multiple times (n = 8). Even in the presence of high concentration of interfering compounds such as cis-3-hexenol, hexyl acetate and cis-hexenyl acetate, AuNP-SPCE retained >95% of its methyl salicylate response. The electroanalytical results of soybean extract showed that AuNP-SPCE can be employed for the determination of methyl salicylate in real samples.
Circularly polarized light detection with hot electrons in chiral plasmonic metamaterials (2015)

Circularly polarized light is utilized in various optical techniques and devices. However, using conventional optical systems to generate, analyse and detect circularly polarized light involves multiple optical elements, making it challenging to realize miniature and integrated devices. While a number of ultracompact optical elements for manipulating circularly polarized light have recently been demonstrated, the development of an efficient and highly selective circularly polarized light photodetector remains challenging. Here we report on an ultracompact circularly polarized light detector that combines large engineered chirality, realized using chiral plasmonic metamaterials, with hot electron injection. We demonstrate the detector's ability to distinguish between left and right hand circularly polarized light without the use of additional optical elements. Implementation of this photodetector could lead to enhanced security in fibre and free-space communication, as well as emission, imaging and sensing applications for circularly polarized light using a highly integrated photonic platform.
Covid-19 Update (2020)

Find out more about our Cleaning Protocols for Pilrig House Apartment in the context of Covid-19.
Retinal Microvascular Abnormalities and MRI-Defined Subclinical Cerebral Infarction (2005)

Retinal microvascular abnormalities are associated with MRI-defined subclinical cerebral infarcts independent of stroke risk factors. These data suggest that retinal photography may be useful for studying subclinical cerebrovascular disease in population-based studies.
Physical Activity Intensity Monitoring of Hospital Workers using a Wearable Sensor (2018)

Monitoring physical activity can be important to maintain a healthy lifestyle. This is the case with shift workers, who, due to their unorthodox sleep schedules, can develop health issues. This paper presents a model for classifying physical activity intensity into four levels: sedentary, light, mod
ABSORPTION OF ALKALIZED INTRAVESICAL LIDOCAINE IN NORMAL AND INFLAMED BLADDERS: (2001)

Pharmacokinetic studies have shown that intravesical lidocaine is not sufficiently absorbed by human bladders to achieve significant serum levels and it only provides a superficial local anesthetic effect. We investigated the pharmacokinetics of alkalized intravesical lidocaine in healthy volunteers and patients with interstitial cystitis to determine a safe dose of buffered lidocaine, the effect of interstitial cystitis on lidocaine uptake and the acute local anesthetic effect on bladder pain in interstitial cystitis.An initial dose finding study was done in 12 healthy volunteers using 4, 5 and 6 mg./kg. 5% lidocaine buffered with 8.4% sodium bicarbonate. Serial lidocaine levels were measured for 3 hours. Serum measurement was repeated in 12 patients with interstitial cystitis using 5 mg/kg. 5% lidocaine with sodium bicarbonate daily for 2 days. Patients rated pain before and during treatment.Healthy volunteers and patients with interstitial cystitis had similar lidocaine absorption profiles with a peak of 1.06 microg/ml. (range 0.66 to 1.71) and 1.3 (range 0.2 to 2.0) at about 30 minutes. Mean pain score in the interstitial cystitis group decreased from a baseline of 6.0 to 1.8 on day 1 and 0.6 on day 2. There were complaints of urethral discomfort after voiding the buffered lidocaine in each group.Alkalization provides safe and predictable lidocaine absorption into the bladder, as indicated by therapeutic systemic levels in healthy and inflamed bladders. Furthermore, the decrease in acute pain scores in the interstitial cystitis group indicated a concentration of local anesthetic within the bladder wall that was sufficient to block the sensory neurons within the submucosal plexus.
Beam Structures: Classical and Advanced Theories (2011)

Beam theories are exploited worldwide to analyze civil, mechanical, automotive, and aerospace structures. Many beam approaches have been proposed during the last centuries by eminent scientists such as Euler, Bernoulli, Navier, Timoshenko, Vlasov, etc. Most of these models are problem dependent: they provide reliable results for a given problem, for instance a given section and cannot be applied to a different one. Beam Structures: Classical and Advanced Theories proposes a new original unified approach to beam theory that includes practically all classical and advanced models for beams and which has become established and recognised globally as the most important contribution to the field in the last quarter of a century. The Carrera Unified Formulation (CUF) has hierarchical properties, that is, the error can be reduced by increasing the number of the unknown variables. This formulation is extremely suitable for computer implementations and can deal with most typical engineering challenges. It overcomes the problem of classical formulae that require different formulas for tension, bending, shear and torsion; it can be applied to any beam geometries and loading conditions, reaching a high level of accuracy with low computational cost, and can tackle problems that in most cases are solved by employing plate/shell and 3D formulations.
Clay-Organic Complexes as Adsorbents for Phenol and Chlorophenols (1986)

Abstract Several clay-organic complexes were synthesized by placing quaternary ammonium cations on smectite by cation exchange. They were then examined for their ability to adsorb phenol and several of its chlorinated congeners. The organic cations used were: hexadecylpyridinium (HDPY + ), hexadecyltri-methyl ammonium (HDTMA + ), trimethylphenyl ammonium (TMPA), and tetramethylammonium (TMA + ). The complexes containing long-chain alkyl (hexadecyl) groups were the most hydrophobic and adsorbed the phenols from water in proportion to their hydrophobicities, which increase with chlorine addition (phenol < chlorophenol < dichloropohenol < trichlorophenol). With n-hexane as the solvent, different adsorption was found which depended on the type and degree of solvent interactions with the compound and the clay-organic complex. Thus, the amount of adsorption of these phenols on clay-organic complexes was dependent on the relative energies of adsorbent-adsorbate and adsorbate-solvent interactions.