gebhart/patrepeval huggingface dataset:
A high performance modular embedded ROM architecture (2002)

We describe a CMOS Read Only Memory architecture designed for high performances and low power consumption using domino logic. Short read delays are achieved using hierarchical evaluation of the read busses, at the price of some more material. Partial block evaluation allows power consumption to be greatly reduced for blocks with an important number of words, turning into an advantage this material increase. This architecture is well suited for memories embedded within synchronous systems due to it excellent speed/power performance. The architecture implementation is done as a parameterized generator, using a tiler and leaf cell approach. The leaf cells are designed using symbolic layout, providing a high degree of process independence. The tiler is written using the general purpose C language to ensure software portability.
Synthese, Radiomarkierung sowie in vitro- und in vivo-Evaluierung verschiedener Chelator-Biomolekül- Systeme mit den Radionukliden 68Ga, 89Zr und 177Lu (2017)

230 Seiten
Asian Citrus Psyllid (2006)

Much has changed since the 2006 release of this publication. Research and treatment methods are changing. For the latest information on Asian Citrus Psyllid visit UC ANR's interactive website on <A HREF="https://ucanr.edu/sites/ACP" TARGET="_blank"> <STRONG>ACP/HLB management.</STRONG></a> for growers, home owners, and master gardeners.
Efficient Interpretation by Transforming Data Types and Patterns to Functions (2005)

\n Contains fulltext :\n 35911_pre.pdf (Author’s version preprint ) (Open Access)\n \n Contains fulltext :\n 35911_pos.pdf (Author’s version postprint ) (Open Access)\n
AAV vector-mediated in vivo reprogramming into pluripotency (2018)

In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds vast potential for basic research and regenerative medicine. However, it remains hampered by a need for vectors to express reprogramming factors (Oct-3/4, Klf4, Sox2, c-Myc; OKSM) in selected organs. Here, we report OKSM delivery vectors based on pseudotyped Adeno-associated virus (AAV). Using the AAV-DJ capsid, we could robustly reprogram mouse embryonic fibroblasts with low vector doses. Swapping to AAV8 permitted to efficiently reprogram somatic cells in adult mice by intravenous vector delivery, evidenced by hepatic or extra-hepatic teratomas and iPSC in the blood. Notably, we accomplished full in vivo reprogramming without c-Myc. Most iPSC generated in vitro or in vivo showed transcriptionally silent, intronic or intergenic vector integration, likely reflecting the increased host genome accessibility during reprogramming. Our approach crucially advances in vivo reprogramming technology, and concurrently facilitates investigations into the mechanisms and consequences of AAV persistence.
Effects of the Long-Term Administration of Nebivolol on the Clinical Symptoms, Exercise Capacity, and Left Ventricular Function of Patients with Diastolic Dysfunction: Results of the ELANDD Study (2011)

Compared with placebo, 6 months treatment with nebivolol did not improve exercise capacity in patients with HFPEF. Its negative chronotropic effect may have contributed to this result.
Frequency of Micronuclei in Hepatocytes Following X and Fast-Neutron Irradiations: An Analysis by a Linear-Quadratic Model (1990)

The usefulness of the micronucleus assay for investigating the radiation response of hepatocytes was examined. The frequency was defined as the ratio of the total number of micronuclei to the number of hepatocytes examined. The dose-response curves were curvilinear after X rays and linear after neutrons. These dose-response curves were analyzed by a linear-quadratic model, frequency = aD + bD2 + c. The a/b ratio was 3.03 +/- 1.26 Gy following X irradiation. This value is within the range of the alpha/beta ratios reported by others using the clonogenic assay of hepatocytes. While the a/b value for neutrons was 24.3 +/- 11.7 Gy, the maximum relative biological effectiveness of neutrons was 6.30 +/- 2.53. Since the micronucleus assay is simple and rapid, it may be a good tool for evaluating the radiation response of hepatocytes in vivo.
Neurobiological Mechanisms of Acupuncture for Some Common Illnesses: A Clinician's Perspective (2013)

This paper presents some previously proposed neurobiological mechanisms on how acupuncture may work in some clinical applications from a clinician's perspective. For the treatment of musculoskeletal conditions, the proposed mechanisms included microinjury, increased local blood flow, facilitated healing, and analgesia. Acupuncture may trigger a somatic autonomic reflex, thereby affecting the gastric and cardiovascular functions. Acupuncture may also change the levels of neurotransmitters such as serotonin and dopamine, thereby affecting the emotional state and craving. This mechanism may form the basis for the treatment of smoking cessation. By affecting other pain-modulating neurotransmitters such as met-enkephalin and substance P along the nociceptive pathway, acupuncture may relieve headache. Acupuncture may affect the hypothalamus pituitary axis and reduce the release of the luteinizing hormone in the treatment of polycystic ovary syndrome. In addition, two other approaches to the acupuncture mechanism, the fascia connective tissue network and the primo vascular system, are briefly reviewed. Finally, the idea of true versus sham acupuncture points, which are commonly used in clinical trials, is examined because the difference between true and sham points does not exist in the neurobiological model.
Using Market-Based Spectrum Policy to Promote the Public Interest (1997)

With the increasing demand for spectrum to accommodate emerging technologies, and the discovery that higher frequencies are usable, the FCC has replaced its reliance on administrative mechanisms for allocating spectrum with a more flexible, market-based approach. The FCC can best accomplish its mission of promoting the public interest by continuing to rely on competitive market forces and by establishing a clear and consistent paradigm for approaching allocation, assignment, usage, and other policies. Such a paradigm envisions an FCC that would actively monitor spectrum to remedy situations in which it is not used to its full value; establish mechanisms to reduce new services' need for immediate secondary market transactions; set and enforce minimally restrictive baseline rules governing interference and health effects; maximize the amount of spectrum available to users; and, in some cases, intervene in markets to correct significant market failures.
Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone. (1984)

The production of tylosin by Streptomyces fradiae KA-427 in a defined medium was inhibited by ammonium ions and by inorganic phosphate. The production of protylonolide, an early lactonic intermediate of tylosin biosynthesis with the same carbon skeleton as tylosin aglycone, by a mutant of strain KA-427 was also reduced by these two kinds of ions. In contrast, the bioconversion of protylonolide to tylosin by another mutant was less susceptible to ammonium ions but was sensitive to inorganic phosphate. The addition of protylonolide to a culture of S. fradiae KA-427 increased the tylosin yield, suggesting that aglycone synthesis is limiting under the conditions used. When L-valine, L-leucine, L-isoleucine, L-threonine, or the corresponding 2-keto acid was added to the culture medium, the protylonolide titer increased. The addition of [14C]valine gave rise to [14C]protylonolide. 13C NMR spectroscopic analysis revealed that iso-butyrate, which is a valine metabolite, was incorporated into protylonolide at the carbons known to originate from propionate and n-butyrate. Taking account of these findings, the regulation of tylosin biosynthesis in S. fradiae by ammonium ion is discussed in relation to amino acid metabolism.
A 92 GHz GaN HEMT voltage-controlled oscillator MMIC (2014)

In this paper, we report state-of-the-art high frequency performance of a W-band voltage-controlled oscillator (VCO) MMIC realized in a 0.1 μm AlGaN/GaN HEMT technology. The oscillation frequency of the VCO can be tuned between 85.6 and 92.7 GHz, which is a relative tuning bandwidth of 8%. The achieved maximum output power is as high as 10.6 dBm. The phase noise of the VCO varies from -80.2 to -90.2 dBc/Hz at 1 MHz offset from the carrier over the tuning voltage range.
Total Synthesis of (−)-Okilactomycin (2007)

A highly convergent synthesis of (-)-okilactomycin is described. Key reactions of this synthesis include a strategy-level diastereoselective oxy-Cope rearrangement/oxidation sequence, a Petasis-Ferrier union/rearrangement tactic, and an efficient RCM reaction to construct the 13-membered macrocyclic ring.
Gelled Scale Inhibitor Treatment for Improved Placement in Long Horizontal Wells at Norne and Heidrun Fields (2009)

Summary The success of a scale inhibitor treatment depends on placement efficiency. The scale inhibitor should be placed so that all water-producing intervals accept a sufficient quantity of the total treatment volume. If significant permeability or pressure variations are present in the interval to be treated, treatment fluid will enter the zones with the higher permeability and lower pressure, leaving little fluid to treat the other zones, which can be the water-producing zones. The challenge is even greater in long, horizontal wells with significant permeability and pressure contrast. To achieve a more uniform fluid coverage, the original flow distribution across intervals often needs to be altered. The methods used to alter this are called "diversion" methods. The purpose is to divert the flow from one portion of the interval to another. In response to this challenge, a joint study with the objective of improving the placement of treatment fluids was initiated by a major operator in the North Sea and two service companies in 2002. The joint work resulted in development of a fully viscosified scale inhibitor system. The system comprises a purified xanthan viscosify-ing agent, a standard scale inhibitor for downhole scale squeezing, and a breaker to achieve controlled gel breaking down hole. The system has been field tested at Norne field in two long horizontal wells and at Heidrun field in one long deviated well, all with significant permeability variations and crossflow. The operations were successful and the scale treatments have protected the wells from scaling. This paper describes the product qualification process, placement simulation, temperature prediction, gel breaking characteristics, case histories, and post-job evaluation.
Joint Time and Frequency Dissemination Network Over Delay-Stabilized Fiber Optic Links (2015)

A precise fiber-based time and frequency dissemination scheme for multiple users with a tree-like branching topology is proposed. Through this scheme, ultrastable signals can be easily accessed online without affecting other sites. The scheme is tested through an experiment, in which a modulated frequency signal and a synchronized time signal are transferred to multiple remote sites over delay-stabilized fiber optic links that are over 50 km long. Results show that the relative stabilities are 5 x 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-14</sup> at 1 s and 2 x 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-17</sup> at 104 s. Meanwhile, compared with each site, time synchronization precision is less than 80 ps. These results can pave the way to practical applications in joint time and frequency dissemination network systems.
A compact GaAs MESFET-based push-push oscillator MMIC using differential topology with low phase-noise performance (2002)

We present a fully integrated 6.7 GHz push-push oscillator MMIC using a cross-coupled differential topology with a capacitive coupling feedback in a commercial GaAs MESFET process. The push-push oscillator shows phase noise of -118.83 dBc/Hz at an offset frequency of 600 kHz with a 3.3 V supply voltage. This low phase-noise performance is comparable to, or better than, the best reported results of 5/spl sim/6 GHz-band oscillators implemented in CMOS and SiGe HBT processes. A 6.4 GHz fundamental oscillator MMIC using the cross-coupled differential topology was also fabricated. The measured phase-noise of the fundamental oscillator is -108 dBc/Hz at an offset frequency of 600 kHz. In addition to the low phase-noise, the push-push oscillator in this paper occupies a compact area of 480/spl times/500 /spl mu/m/sup 2/. To our knowledge, it is the first implementation of a GaAs MESFET-based push-push oscillator MMIC using the cross-coupled differential topology with capacitive coupling feedback. This work is also the first report that shows the low phase-noise performance of the push-push oscillator using the differential topology as compared with that of the fundamental oscillator.
Adoptive T Cell Therapy for Epstein–Barr Virus Complications in Patients With Primary Immunodeficiency Disorders (2018)

Patients with primary immunodeficiency disorders (PID) have an increased risk from acute and chronic Epstein-Barr Virus (EBV) viral infections and EBV-associated malignancies. Hematopoietic stem cell transplantation (HSCT) is a curative strategy for many patients with PID, but EBV-related complications are common in the immediate post-transplant period due to delayed reconstitution of T cell immunity. Adoptive T cell therapy with EBV-specific T cells is a promising therapeutic strategy for patients with PID both before and after HSCT. Here we review the methods used to manufacture EBV-specific T cells, the clinical outcomes, and the ongoing challenges for future development of the strategy.
Urban Traffic Control Based on Model Free Adaptive Iterative Learning Control Scheme (2019)

For urban traffic control, it's always difficult to establish an accurate traffic mathematics model, and urban traffic flow has the characteristic of repeatability. In this paper, a kind of urban traffic control strategy based on model free adaptive iterative learning control (UTC-MFAILC) scheme is put forward. In the proposed control strategy, the traffic controller repeats the same control task in a finite time period for several times. For each repeated task, the traffic controller can learn from the previous execution to improve control performance using MFAILC scheme without using traffic mathematics model. Simulation study verifies the feasibility and effectiveness of the proposed control strategy.
Towards modelling the impact of cyber attacks on a smart grid (2011)

This paper provides an introduction to cyber attack impact analysis in the smart grid and highlights existing research in the field. We present an impact analysis framework where we focus on the model synthesis stage where both cyber and physical grid entity relationships are modelled as directed graphs. Each node of the graph has associated state information that is governed by dynamical system equations that model the physics of the interaction (for electrical grid components) or functionality (for cyber grid elements). We illustrate how cause-effect relationships can be conveniently expressed for both analysis and extension to large-scale smart grid systems.
Effect of High-Resistivity Si Substrate on Antenna Transmission Gain for On-Chip Wireless Interconnects (2004)

Characterization of small integrated dipole antennas on high-resistivity Si substrates for use in on-chip wireless interconnection was performed and results were compared with those obtained by 3-dimensional (3D) finite-element simulation. The integrated antennas on standard P-type Si substrates with resistivities of 10 Ω·cm, 79.6 Ω·cm, 132 Ω·cm and 2.29 kΩ·cm, and one high-energy proton-implanted Si substrate were measured. When antenna length was 3.0 mm and antenna distance was 3.0 cm on a 10-Ω·cm-resistivity Si substrate, the antenna transmission gain was -43 dB. The antenna transmission gain was improved to -24 dB on the 2.29 kΩ·cm Si substrate. By using high-resistivity Si substrates, signal transmission via integrated antennas becomes possible.
Development of an Artificial Intelligence Powered TIG Welding Algorithm for the Prediction of Bead Geometry for TIG Welding Processes using Hybrid Deep Learning (2020)

Recent developments in artificial intelligence (AI) modeling tools allows for envisaging that AI will remove elements of human mechanical effort from welding operations. This paper contributes to this development by proposing an AI tungsten inert gas (TIG) welding algorithm that can assist human welders to select desirable end factors to achieve good weld quality in the welding process. To demonstrate its feasibility, the proposed model has been tested with data from 27 experiments using current, arc length and welding speed as control parameters to predict weld bead width. A fuzzy deep neural network, which is a combination of fuzzy logic and deep neural network approaches, is applied in the algorithm. Simulations were carried out on an experimental test dataset with the AI TIG welding algorithm. The results showed 92.59% predictive accuracy (25 out of 27 correct answers) as compared to the results from the experiment. The performance of the algorithm at this nascent stage demonstrates the feasibility of the proposed method. This performance shows that in future work, if its predictive accuracy is improved with human input and more data, it could achieve the level of accuracy that could support the human welder in the field to enhance efficiency in the welding process. The findings are useful for industries that are in the welding trade and serve as an educational tool.
Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production (2014)

Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin (Ig) heavy-chain (hIGH), kappa-chain (hIGK), and lambda-chain (hIGL) germline loci produced physiological levels of hIgGs when both of the bovine immunoglobulin mu heavy-chains, bIGHM and bIGHML1, were homozygously inactivated (bIGHM-/-, bIGHML1-/-; double knockouts or DKO). However, because endogenous bovine immunoglobulin light chain loci are still intact, the light chains are produced both from the hIGK and hIGL genomic loci on the HAC and from the endogenous bovine kappa-chain (bIGK) and lambda-chain (bIGL) genomic loci, resulting in the production of fully hIgGs (both Ig heavy-chains and light-chains are of human origin: hIgG/hIgκ or hIgG/hIgλ) and chimeric hIgGs (Ig heavy-chains are of human origin while the Ig light-chains are of bovine origin: hIgG/bIgκ or hIgG/bIgλ). To improve fully hIgG production in Tc cattle, we here report the deletion of the entire bIGL joining (J) and constant (C) gene cluster (bIGLJ1-IGLC1 to bIGLJ5-IGLC5) by employing Cre/loxP mediated site-specific chromosome recombination and the production of triple knockout (bIGHM-/-, bIGHML1-/- and bIGL-/-; TKO) Tc cattle. We further demonstrate that bIGL cluster deletion greatly improves fully hIgGs production in the sera of TKO Tc cattle, with 51.3% fully hIgGs (hIgG/hIgκ plus hIgG/hIgλ).
MACsec-Based Security for Automotive Ethernet Backbones (2017)

The increasing complexity of automotive electronics and the communication of cars with the external environment have led to extensive security issues. The car industry is moving towards the use of Ethernet backbones to improve the performance and reduce the complexity of in-car networks. In this paper, we propose a security solution for automotive Ethernet-based communications. We designed a hardware Media Access Control (MAC) layer based on the MAC Security Standard (MACsec) that considers the specific constraints of the automotive world in terms of latency, throughput and area. From a security point of view, our solution guarantees the confidentiality, integrity and authenticity of data. Furthermore, the system can be configured before synthesis to meet the security needs of the context in which the Ethernet communication is used. We synthesized our architecture on a low-power 28[Formula: see text]nm standard-cell CMOS technology, which is appropriate for automotive microcontrollers. The results show that our implementation is suitable for 100[Formula: see text]Mbps, 1[Formula: see text]Gbps and 10[Formula: see text]Gbps Ethernet speeds introducing less than 350[Formula: see text]ns of latency. The size of the circuit varies from 285 to 622 kgates depending on the required level of security and the required features.
Development of Wide-Band Compensation Film to Improve Viewing Angle of Vertical Alignment Liquid Crystal Display (2011)

수직배향 액정디스플레이의 시야각 향상을 위한 광대역 보상필름을 개발하였다. 상용화된 수직배향 액정디스플레이는 측면 시야각을 보상하는 위상차 필름을 필요로 한다. 일반적으로 triacetylcellulose(TAC)에 광학첨가제를 첨가한 후 제막연신을 통하여 수직배향 액정디스플레이용 위상차 필름을 제작하는데, 첨가되는 광학첨가제의 화학구조에 따라 필름의 위상차와 파장분산 특성이 달라진다. 본 연구에서는 첨가제에 따른 분극률 이방성을 양자역학적으로 계산하고, 선택된 중심 이성질체에 사이드 그룹을 치환시켜 파장별 분극률 이방성을 또한 계산하였다. 특히, 치환기가 methoxy와 propionate인 경우에 치환위치와 숫자에 따른 파장별 분극률 이방성을 비교하였다. 2개의 propionate 그룹이 meta 위치에 있을 경우가 파장분산 특성이 가장 완만한 것을 양자역학적 계산을 통하여 예측하였으며 이를 실험을 통해 증명하였다. 파장분산 특성이 완만하다는 것은 LCD 시야각 특성이 광원의 파장에 따라 덜 변한다는 의미이며, 현재 수준보다 우수한 화질을 구현할 수 있다.
The YCB object and Model set: Towards common benchmarks for manipulation research (2015)

In this paper we present the Yale-CMU-Berkeley (YCB) Object and Model set, intended to be used for benchmarking in robotic grasping and manipulation research. The objects in the set are designed to cover various aspects of the manipulation problem; it includes objects of daily life with different shapes, sizes, textures, weight and rigidity, as well as some widely used manipulation tests. The associated database provides high-resolution RGBD scans, physical properties and geometric models of the objects for easy incorporation into manipulation and planning software platforms. A comprehensive literature survey on existing benchmarks and object datasets is also presented and their scope and limitations are discussed. The set will be freely distributed to research groups worldwide at a series of tutorials at robotics conferences, and will be otherwise available at a reasonable purchase cost.
Controlling Long-Lived Triplet Generation from Intramolecular Singlet Fission in the Solid State (2017)

The conjugated polymer poly(benzothiophene dioxide) (PBTDO1) has recently been shown to exhibit efficient intramolecular singlet fission in solution. We investigate the role of intermolecular interactions in triplet separation dynamics after singlet fission. We use transient absorption spectroscopy to determine the singlet fission rate and triplet yield in two polymers differing only by side-chain motif in both solution and the solid state. Whereas solid-state films show singlet fission rates identical to those measured in solution, the average lifetime of the triplet population increases dramatically and is strongly dependent on side-chain identity. These results show that it may be necessary to carefully engineer the solid-state microstructure of these "singlet fission polymers" to produce the long-lived triplets needed to realize efficient photovoltaic devices.