gebhart/patrepeval huggingface dataset:
Measures of cognitive function in persons with varying degrees of sleep‐disordered breathing: the Sleep Heart Health Study (2002)

Epidemiologic literature suggests that persons with clinically diagnosed sleep apnoea frequently have impaired cognitive function, but whether milder degrees of sleep-disordered breathing (SDB) are associated with cognitive dysfunction in the general population is largely unknown. Approximately 1700 subjects free of clinically diagnosed SDB underwent at-home polysomnography (PSG) as part of the Sleep Heart Health Study (SHHS) and completed three cognitive function tests within 1-2 years of their PSG: the Delayed Word Recall Test (DWR), the WAIS-R Digit Symbol Subtest (DSS), and the Word Fluency test (WF). A respiratory disturbance index (RDI) was calculated as the number of apnoeas and hypopnoeas per hour of sleep. After adjustment for age, education, occupation, field centre, diabetes, hypertension, body-mass index, use of CNS medications, and alcohol drinking status, there was no consistent association between the RDI and any of the three cognitive function measures. There was no evidence of a dose-response relation between the RDI and cognitive function scores and the adjusted mean scores by quartiles of RDI never differed from one another by more than 5% for any of the tests. In this sample of free-living individuals with mostly mild to moderate levels of SDB, the degree of SDB appeared to be unrelated to three measures of cognitive performance.
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1 (2006)

Glucocorticoids (GCs), which are used in the treatment of immune-mediated inflammatory diseases, inhibit the expression of many inflammatory mediators. They can also induce the expression of dual specificity phosphatase 1 (DUSP1; otherwise known as mitogen-activated protein kinase [MAPK] phosphatase 1), which dephosphorylates and inactivates MAPKs. We investigated the role of DUSP1 in the antiinflammatory action of the GC dexamethasone (Dex). Dex-mediated inhibition of c-Jun N-terminal kinase and p38 MAPK was abrogated in DUSP1-/- mouse macrophages. Dex-mediated suppression of several proinflammatory genes (including tumor necrosis factor, cyclooxygenase 2, and interleukin 1alpha and 1beta) was impaired in DUSP1-/- mouse macrophages, whereas other proinflammatory genes were inhibited by Dex in a DUSP1-independent manner. In vivo antiinflammatory effects of Dex on zymosan-induced inflammation were impaired in DUSP1-/- mice. Therefore, the expression of DUSP1 is required for the inhibition of proinflammatory signaling pathways by Dex in mouse macrophages. Furthermore, DUSP1 contributes to the antiinflammatory effects of Dex in vitro and in vivo.
Polymers with Dual Light-Triggered Functions of Shape Memory and Healing Using Gold Nanoparticles (2013)

Shape-memory and stimuli-healable polymers (SMP and SHP) are two types of emerging smart materials. Among the many stimuli that can be used to control SMP and SHP, light is unique because of its unparalleled remote activation and spatial control. Generally, light-triggered shape memory and optically healable polymers are different polymers and it is challenging to endow the same polymer with the two light-triggered functions because of their structural incompatibility. In this paper, we describe a general polymer design that allows a single material to exhibit both light-controlled shape memory and optical healing capabilities. We show that by chemically cross-linking a crystalline polymer and loading it with a small amount of gold nanoparticles (AuNPs), the polymer displays optically controllable shape memory and fast optical healing based on the same localized heating effect arising from the surface plasmon resonance of AuNPs. The photothermal effect controls, on the one hand, the shape memory process by tuning the temperature with respect to Tm of the crystalline phase and, on the other hand, activates the damage healing through crystal melting and recrystallization. Moreover, we show that these two features can be triggered separately in a sequential manner.
The Early Fracture Hematoma and Its Potential Role in Fracture Healing (2010)

Research regarding the potency and potential of the fracture hematoma has begun to receive increasing attention. However, currently there is a paucity of relevant literature on the capability and composition of the fracture hematoma. This review briefly summarizes the regenerative fracture healing process and the close interplay between the skeletal and immune systems. The role of immune cells in wound healing is also discussed to clarify their involvement in immunological processes during regeneration. We attempt to describe the current state of knowledge regarding the fracture hematoma as the initial stage of the regenerative process of fracture healing. The review discusses how a better understanding of immune reactions in the hematoma may have implications for bone tissue engineering strategies. We conclude the review by emphasizing how additional investigations of the initial phase of healing will allow us to better differentiate between deleterious and beneficial aspects of inflammation, thereby facilitating improved fracture treatment strategies.
Trans‐<i>N</i>‐deoxyribosylase from <i>Lactobacillus helveticus</i> (1971)

The deoxyribose‐transferring enzyme from Lactobacillus helveticus has been purified to homogeneity with subsequent crystallization under different conditions. The enzyme has a molecular weight of about 82000 as estimated by gel filtration. Kinetic data for the deoxyribosyl transfer between various purine and pyrimidine bases are reported.
The Cannabinoid 1 Receptor Antagonist, AM251, Prolongs the Survival of Rats with Severe Acute Pancreatitis (2005)

It has recently been recognized that anandamide (arachidonylethanolamide), which is an endogeneous-cannabinoid (endocannabinoid), mediates septic shock. Cannabinoid means a mind-active material in cannabis (marijuana). Anandamide is mainly produced by macrophages. Cannabinoid 1 (CB1) receptor, which is one of the cannabiniod receptors, is also known to mediate hypotensive shock. The role of endocannabinoids in the progression of acute pancreatitis is unclear. The aims of this study are to clarify their relationship and to find a new therapeutic strategy by regulating the endocannabinoid signaling in acute pancreatitis. Male Wistar rats were injected with caerulein intravenously to induce mild edematous pancreatitis or injected with 5% sodium taurocholate to the bilio-pancreatic duct to induce severe necrotizing pancreatitis. The animals in the latter group were also injected with a CB1 receptor antagonist, AM251, or vehicle solution to see if the inhibition of endocannabinoids improves their survival. Plasma anandamide level was measured by the liquid chromatography/tandem mass spectrometry method. In both models of acute pancreatitis, the plasma anandamide levels were increased, and the levels were significantly higher in rats with severe necrotizing pancreatitis than those in rats with mild edematous pancreatitis. The mean arterial pressure and survival rate were significantly improved by the treatment with AM251, despite that the local inflammatory changes in the pancreas and various parameters (white blood cells, hematocrit, serum amylase, and serum interleukin-6) were similar. This is the first report to show that endocannabinoids are involved in the deterioration of acute pancreatitis and that the down-regulation of endocannabinoid signaling may be a new therapeutic strategy for severe acute pancreatitis.
Critical Salt Bridges Guide Capsid Assembly, Stability, and Maturation Behavior in Bacteriophage HK97 (2010)

HK97 is a double-stranded DNA bacteriophage that undergoes dramatic conformational changes during viral capsid maturation and for which x-ray structures, at near atomic resolution, of multiple intermediate and mature capsid states are available. Both amide H/(2)H exchange and crystallographic comparisons between the pre-expanded Prohead II particles and the expanded Head II of bacteriophage HK97 revealed quaternary interactions that remain fixed throughout maturation and appear to maintain intercapsomer integrity at all quasi- and icosahedral 3-fold axes. These 3-fold staples are formed from Arg and Glu residues and a metal binding site. Mutations of either Arg-347 or Arg-194 or a double mutation of E344Q and E363A resulted in purification of the phage in capsomer form (hexamers and pentamers). Mutants that did assemble had both decreased thermal stability and decreased in vitro expansion rates. Amide H/(2)H exchange mass spectrometry showed that in the wild type capsid some subunits had a bent "spine" helix (highly exchanging), whereas others were straight (less exchanging). Similar analysis of the never assembled mutant capsomers showed uniform amide exchange in all of these that was higher than that of the straight spine helices (characterized in more mature intermediates), suggesting that the spine helix is somewhat bent prior to capsid assembly. The result further supports a previously proposed mechanism for capsid expansion in which the delta domains of each subunit induce a high energy intermediate conformation, which now appears to include a bent helix during capsomer assembly.
KNOWLEDGE ORGANIZATIONAL CAPABILITIES AND ORGANIZATIONALPERFORMANCE: SEARCHING FOR A MODEL TO THE INTERORGANIZATIONALNETWORKS (2008)

It seems to be important for maintainable growth of the
					Interorganizational Networks (IN's) development of knowledge
					organizational capabilities (KOC's), once such capabilities are
					related with the knowledge flows emerged inside of the network as
					well as in the use of the knowledge external sources. Such KOC's
					are subdivided in two complementary types: the knowledge
					infrastructure organizational capability (KIOC), that mean the
					group of linked capabilities: the technology, it structures
					organizational and existent organizational culture in a IN; and the
					absorptive capacity of the organizational knowledge (ACOK),
					composed by abilities for acquisition, conversion and application
					of the knowledge in those IN's. The group of KOC's when developed
					by some IN in an effective way can impact in its organizational
					performance (OP), providing the base for a continuous growth and
					greater competitiveness to those organizational arrangements.
					Finally, the paper presents a conceptual model that search for to
					integrate a group of propositions around those phenomenons, their
					limitations and a group of final considerations.
Ballistocardiography with fiber optic sensor in headrest position: A feasibility study and a new processing algorithm (2013)

Ballistocardiography (BCG) is a promising unobtrusive method for home e-healthcare systems, and has attracted increasing interest in recent years along with technological advances in related biomedical, electrical engineering and computer science fields. While existing systems have investigated the efficacy of BCG setups in bed, backrest, seat or scale positions, we propose to study BCG in headrest position that will allow new practical and portable applications. To this end, we designed and implemented a multi-modality sensing system including a high-sensitivity microbend fiber optic BCG sensor. In this preliminary study, we have collected multi-modality physiological data on 3 human subjects. We ran extensive analysis on BCG in correlation with ECG, and identified special characteristics of the signal in the new BCG setup. The result suggests that new appropriate computing techniques are necessary for accurately recovering the heart beat signal. Therefore, we developed a novel algorithm for heart beat detection. We evaluate the algorithm with the data and demonstrate that it can accurately compute heart rate intervals in the headrest BCG despite significant signal distortion.
Transistorlike Device for Heating and Cooling Based on the Thermal Hysteresis of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi>VO</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (2016)

Manipulating the flow of heat, particularly in analogy to the flow of electrons (current), has become a major research theme. A $t\phantom{\rule{0}{0ex}}h\phantom{\rule{0}{0ex}}e\phantom{\rule{0}{0ex}}r\phantom{\rule{0}{0ex}}m\phantom{\rule{0}{0ex}}a\phantom{\rule{0}{0ex}}l$ $t\phantom{\rule{0}{0ex}}r\phantom{\rule{0}{0ex}}a\phantom{\rule{0}{0ex}}n\phantom{\rule{0}{0ex}}s\phantom{\rule{0}{0ex}}i\phantom{\rule{0}{0ex}}s\phantom{\rule{0}{0ex}}t\phantom{\rule{0}{0ex}}o\phantom{\rule{0}{0ex}}r$ made from a phase-change material can efficiently heat or cool to control the temperature of, say, an integrated circuit. The authors propose a far-field device exploiting the thermal hysteresis of vanadium dioxide, in which a structural phase transition is accompanied by a dramatic change in emissivity, providing jumps in temperature and heat flux at the base terminal.
Design of a fractional-order adaptive integral sliding mode controller for the trajectory tracking control of robot manipulators (2018)

In this study, trajectory tracking control of six–degrees of freedom robotic manipulator has been performed using the proposed fractional-order adaptive integral sliding mode control scheme. The proposed method is first composed by fractional-order and adaptive integral sliding mode control to achieve the finite-time convergence, chattering-free control inputs, better tracking performance and robustness for the robotic manipulator. Furthermore, an adaptive method has been utilized to evaluate and compensate the uncertain and unknown dynamics of the system without relying on the prior knowledge of the upper bounds. To illustrate the efficiency of the proposed fractional-order adaptive integral sliding mode control method, the real-time experimental studies have been performed for the six–degrees of freedom industrial robot manipulator. The experimental outcomes strongly verified that the proposed controller gives quite well trajectory tracking response and faster convergence compared with the classical integral sliding mode control under the external payload.
The effect of fucoxanthin rich power on the lipid metabolism in rats with a high fat diet (2013)

This study determined the effects of fucoxanthin on gene expressions related to lipid metabolism in rats with a high-fat diet. Rats were fed with normal fat diet (NF, 7% fat) group, high fat diet group (HF, 20% fat), and high fat with 0.2% fucoxanthin diet group (HF+Fxn) for 4 weeks. Body weight changes and lipid profiles in plasma, liver, and feces were determined. The mRNA expressions of transcriptional factors such as sterol regulatory element binding protein (SREBP)-1c, Carnitine palmitoyltransferase-1 (CPT1), Cholesterol 7α-hydroxylase1 (CYP7A1) as well as mRNA expression of several lipogenic enzymes were determined. Fucoxanthin supplements significantly increased plasma high density lipoprotein (HDL) concentration (P < 0.05). The hepatic total lipids, total cholesterols, and triglycerides were significantly decreased while the fecal excretions of total lipids, cholesterol, and triglycerides were significantly increased in HF+Fxn group (P < 0.05). The mRNA expression of hepatic Acetyl-CoA carboxylase (ACC), Fatty acid synthase (FAS), and Glucose-6-phosphate dehydrogenase (G6PDH) as well as SREBP-1C were significantly lower in HF+Fxn group compared to the HF group (P < 0.05). The hepatic mRNA expression of Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) and Acyl-CoA cholesterol acyltransferase (ACAT) were significantly low while lecithin-cholesterol acyltransferase (LCAT) was significantly high in the HF+Fxn group (P < 0.05). There was significant increase in mRNA expression of CPT1 and CYP7A1 in the HF+Fxn group, compared to the HF group (P < 0.05). In conclusion, consumption of fucoxanthin is thought to be effective in improving lipid and cholesterol metabolism in rats with a high fat diet.
Partial Shotgun Sequencing of the <i>Boechera stricta</i> Genome Reveals Extensive Microsynteny and Promoter Conservation with Arabidopsis (2006)

Comparative genomics provides insight into the evolutionary dynamics that shape discrete sequences as well as whole genomes. To advance comparative genomics within the Brassicaceae, we have end sequenced 23,136 medium-sized insert clones from Boechera stricta, a wild relative of Arabidopsis (Arabidopsis thaliana). A significant proportion of these sequences, 18,797, are nonredundant and display highly significant similarity (BLASTn e-value < or = 10(-30)) to low copy number Arabidopsis genomic regions, including more than 9,000 annotated coding sequences. We have used this dataset to identify orthologous gene pairs in the two species and to perform a global comparison of DNA regions 5' to annotated coding regions. On average, the 500 nucleotides upstream to coding sequences display 71.4% identity between the two species. In a similar analysis, 61.4% identity was observed between 5' noncoding sequences of Brassica oleracea and Arabidopsis, indicating that regulatory regions are not as diverged among these lineages as previously anticipated. By mapping the B. stricta end sequences onto the Arabidopsis genome, we have identified nearly 2,000 conserved blocks of microsynteny (bracketing 26% of the Arabidopsis genome). A comparison of fully sequenced B. stricta inserts to their homologous Arabidopsis genomic regions indicates that indel polymorphisms >5 kb contribute substantially to the genome size difference observed between the two species. Further, we demonstrate that microsynteny inferred from end-sequence data can be applied to the rapid identification and cloning of genomic regions of interest from nonmodel species. These results suggest that among diploid relatives of Arabidopsis, small- to medium-scale shotgun sequencing approaches can provide rapid and cost-effective benefits to evolutionary and/or functional comparative genomic frameworks.
Statistical issues raised by the Bellcore data (1994)

There has been a surge of literature claiming that 'Ethernet traffic is self similar' and possesses long range dependence; similar claims have been justified using traffic observations taken from an Ethernet local area network at Bellcore Laboratories. The authors discuss the implications of such claims for the problem of estimating loss probabilities in networks, and their validity. >
Preparation and Structural, Biochemical, and Pharmaceutical Characterizations of Bile Acid-Modified Long-Acting Exendin-4 Derivatives (2009)

To develop an effective long-acting antidiabetic, the GLP-1 analogue of exendin-4 was modified with three different bile acids (BAs; cholic, deoxycholic, or lithocholic acid), at its two lysine residues. The biological, pharmaceutical, and physicochemical characteristics of these exendin-4 analogues were carefully investigated. Biological activity tests demonstrated that the monobile acid substitutions of exendin-4 showed well preserved receptor binding efficacy without noticeable insulinotropic or antidiabetic activity loss. However, physicochemical and pharmacokinetic studies revealed that the albumin-binding properties and in vivo elimination half-lives of BAM1-Ex4s (Lys(27)-BA-Ex4s) were significantly enhanced by increasing the hydrophobicities of the conjugated BAs. Furthermore, the protracted antidiabetic effects of the BAM1-Ex4s were also verified by the prolonged restoration of normoglycemia in type 2 diabetic mice. Accordingly, the present study suggests that the derivatization of exendin-4 with BAs offers a means of producing long-acting GLP-1 receptor agonists for type 2 diabetic therapy.
Glasses in hard spheres with short-range attraction (2004)

We report a detailed experimental study of the structure and dynamics of glassy states in hard spheres with short-range attraction. The system is a suspension of nearly hard-sphere colloidal particles and nonadsorbing linear polymer which induces a depletion attraction between the particles. Observation of crystallization reveals a reentrant glass transition. Static light scattering shows a continuous change in the static structure factors upon increasing attraction. Dynamic light scattering results, which cover 11 orders of magnitude in time, are consistent with the existence of two distinct kinds of glasses, those dominated by interparticle repulsion and caging, and those dominated by attraction. Samples close to the "A3 point" predicted by mode coupling theory for such systems show very slow, logarithmic dynamics.
Real-Time Shot Change Detection Over Online MPEG-2 Video (2004)

The development of technologies and standards intended to enable and organize a variety of innovative services over the infrastructure that supports digital TV requires a parallel evolution of the techniques to manage its main information media: digital video. Particularly, as TV broadcasters confront the provision of dynamic value-added content-based services over the audio-visual information that is being transmitted, they require online annotation of the received digital channels. In order to achieve it, apart from high levels of success in video temporal segmentation-a great resource-consuming task previous to most video annotation techniques-a faster than real-time performance is crucial. This paper describes a software module for video temporal segmentation which is able to detect both abrupt transitions and all types of gradual transitions in real time, with levels of recall and precision not reported up to date for such a large and varied set of video sequences.
Effects of Ca on the Refinement of Microstructure in Aluminum B390 Alloy (2002)

Effects of Ca content on the refinement of primary Si of Aluminum B390 alloy have been examined. Ca was found to have an effect on the refinement of primary Si particle. Primary Si particle size has been refined as Ca content of the melts decreased and cooling rate increased. A control of Ca content by the addition of to the melt was the most efficient in the refinement of primary Si particles. The minimum size of primary Si particles in this study was when a residual content of Ca element in the alloy was 5ppm, Primary Si particle size was refined as primary Si crystallization temperature increased, which was attributed to the decrease of Ca content in the melts.