gebhart/patrepeval huggingface dataset:
A least-movement topology repair algorithm for partitioned wireless sensor-actor networks (2012)

In Wireless Sensor–Actor Networks (WSANs), sensors probe their surroundings and send their data to more capable actor nodes. The actors' response requires them to coordinate their operation. Therefore, a strongly connected inter–actor topology is necessary and tolerance of an actor failure becomes a design requirement. Autonomous repositioning of actors has been deemed as an effective recovery strategy. In this paper, we present a distributed network recovery scheme called Least–Movement Topology Repair (LeMoToR). To restore connectivity, LeMoToR relies on the local view of a node about the network and strives to relocate the least number of nodes. It also reduces the total travelled distance and overall inter–node communication complexity. LeMoToR does not impose pre–failure communication overhead and utilises existing path discovery activities in the network to know the structure of the topology. The performance of LeMoToR is validated analytically and through simulation. The validation results demonstrate the effectiveness of LeMoToR.
Comparison of multiple HLA-A alleles at the DNA level by using Southern blotting and HLA-A-specific probes. (1985)

Numerous alleles of the HLA-A gene have been serologically identified. In this report we present a rapid and straightforward means to assess HLA-A polymorphism at the genomic level. Using 5' and 3' HLA-A-specific DNA probes and Southern blotting, we have placed the recognition sequences for five endonucleases relative to the coding regions of 15 HLA-A alleles. These data permit two interesting conclusions: four of the HLA-A alleles studied are associated with unique restriction fragments, and HLA-A alleles of a cross-reactive group are more closely related at the DNA level than are noncross-reactive alleles.
Robust, efficient upwind finite‐difference traveltime calculations in 3‐D (1993)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1993Robust, efficient upwind finite‐difference traveltime calculations in 3‐DAuthors: William A. SchneiderWilliam A. SchneiderExxon Production Research Co.https://doi.org/10.1190/1.1822288 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822288FiguresReferencesRelatedDetailsCited ByComposite Refractive Index on Electromagnetic Wave Propagating in Spherical MediumIEEE Transactions on Antennas and Propagation, Vol. 68, No. 3Path Delays in the Neutral Atmosphere11 June 2013 SEG Technical Program Expanded Abstracts 1993ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1993 Pages: 1396 publication data© 1993 Copyright © 1993 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION William A. Schneider, Jr, (1993), "Robust, efficient upwind finite‐difference traveltime calculations in 3‐D," SEG Technical Program Expanded Abstracts : 1036-1039. https://doi.org/10.1190/1.1822288 Plain-Language Summary PDF DownloadLoading ...
Apparatus for controlling molten core debris. [LMFBR] (1977)

Disclosed is an apparatus for containing, cooling, diluting, dispersing and maintaining subcritical the molten core debris assumed to melt through the bottom of a nuclear reactor pressure vessel in the unlikely event of a core meltdown. The apparatus is basically a sacrificial bed system which includes an inverted conical funnel, a core debris receptacle including a spherical dome, a spherically layered bed of primarily magnesia bricks, a cooling system of zig-zag piping in graphite blocks about and below the bed and a cylindrical liner surrounding the graphite blocks including a steel shell surrounded by firebrick. Tantalum absorber rods are used in the receptacle and bed. 9 claims, 22 figures.
Adaptive algorithms for reducing PCS network authentication traffic (1997)

Two authentication schemes (ASs) have been proposed in the Electronic Industry Association/Telecommunications Industry Association's (EIA/TIA) Telecommunications Systems Bulletins (TSBs) 51 for incorporation in the cellular industry Interim Standard IS 41 Revision C. In the first scheme, which we refer to as the WS scheme, a unique secret key [also known as shared secret data (SSD)] is shared only between the authentication center (AC) and handset. In the second scheme, referred to as the S scheme, the SSD is also shared with the visited system. The performance of the two schemes can be compared by using the expected number of call originations/terminations between two consecutive registrations or call-to-mobility ratio (CMR). Based on the message flow (accesses to databases), it is apparent that the S scheme outperforms the WS schemes if the CMR ratio is large. The CMRs of users will likely span a wide range and, even for the same user, will perhaps vary from time to time. It is therefore desirable to switch between the ASs based on the users' CMR to reduce the signaling network traffic. We propose two adaptive algorithms to determine how and when to switch between the ASs for a given user. Our performance study indicates that as the CMR of a user changes, the adaptive algorithms automatically select the best AS in real time.
Lipid Angiogenic Factor From Omentum (1984)

Placing the omentum on the brain surface by surgical transposition or transplantation will result in the development of numerous neovascular connections between these two structures. This phenomenon occurs even in the absence of cerebral ischemia, which raised the question as to whether an angiogenic factor was causing the response. A lipid material obtained from the omentum contains a potent angiogenic factor extractable in a chloroform-methanol solvent mixture. Angiogenesis created by this material was observed in the rabbit cornea after only a single injection of the substance. The angiogenic material obtained from the omentum is abundant in supply. This important characteristic offers promise for the purification and identification of its structure, which should allow for extensive animal and clinical studies dealing with the development or inhibition of angiogenesis.
Detection and Differentiation of Bovine Group A Rotavirus Serotypes using Polymerase Chain Reaction-Generated Probes to the VP7 Gene (1992)

Dot and Northern blot hybridization assays were developed to detect and differentiate group A bovine rotavirus serotypes using radiolabeled serotype 6 (Nebraska calf diarrhea virus [NCDV] and United Kingdom [UK] strains) or serotype 10 (Crocker [Cr] strain) VP7 gene probes. Partial length VP7-specific cDNA encompassing areas of major sequence diversity were generated by the polymerase chain reaction (PCR) using either cloned VP7 genes (NCDV and UK strains) or reverse transcribed mRNA (Cr strain) as templates. Radiolabeled probes prepared from the PCR-generated cDNA were tested at various stringency conditions to optimize the hybridization assays. At high stringency conditions (52 C, 50% formamide, 5 x standard saline citrate), the NCDV, UK, and Cr probes serotypically differentiated bovine rotavirus isolates in RNA samples prepared from cell culture propagated viruses or in fecal specimens from infected gnotobiotic calves. The sensitivity and specificity of NCDV and Cr VP7 probes were characterized in dot blot hybridization assays, and the probes were estimated to detect at least 1 ng of viral RNA. The serotyping results obtained using VP7 probes were similar to those obtained using serologic assays. Further development of these assays may provide a useful means for the rapid detection and differentiation of bovine rotavirus serotypes in fecal samples from calves in the field.
Wideband frequency modulation spectroscopy using the quantum cascade laser (2003)

Summary form only given. The quantum cascade (QC) laser is a promising new source for tunable, infrared laser radiation and the spectroscopic capabilities of the QC laser were recently demonstrated. In this report, we extend previous work by demonstrating wideband frequency modulation (FM) of the QC laser and the detection of FM spectroscopic signals from a weakly absorbing sample of molecules.
From Play-In Scenarios To Code: An Achievable Dream. (2000)

The article presents a general, rather sweeping development scheme for complex reactive systems, combining ideas that have been known for a long time with more recent ones. The scheme makes it possible to go from a high-level user-friendly requirements capture method, which is called play-in scenarios, via a rich language for describing message sequencing to a full model of the system, and from there to final implementation. A cyclic process of verifying the system against requirements and synthesizing system parts from the requirements is central to the proposal. The article puts special emphasis on the languages, methods, and computerized tools that allow smooth but rigorous transitions between the various stages of the scheme. In contrast to database systems, the article focuses on systems that have a dominant reactive, event-driven facet. For these systems, modeling and analyzing behavior is the most crucial and problematic issue.
Reduction of surface erosion in fusion reactors (1977)

Some of the major processes leading to surface erosion in fusion reactors are reviewed briefly, including blistering by implanted gas, sputtering by ions, atoms, and neutrons, and vaporization by local heating. Surface erosion affects the structural integrity and limits the lifetime of reactor components exposed to plasma radiation. In addition, some of the processes leading to surface erosion also cause the release of plasma contaminants. Methods proposed to reduce surface erosion have included control of surface temperature, selection of materials with a favorable microstructure, chemical and mechanical treatment of surfaces, and employment of protective surface coatings, wall liners, and divertors. The advantages and disadvantages of some of these methods are discussed.
Anti-Carbamylated Protein (Anti-CarP) Antibodies in Patients Evaluated for Suspected Rheumatoid Arthritis (2022)

(1) Background: Anti-carbamylated protein (CarP) antibodies have been studied as novel markers to aid in the diagnosis and prognosis of rheumatoid arthritis. (2) Methods: A total of 265 samples were included in the evaluation, for which 98 had results for anti-cyclic citrullinated peptide (CCP), 86 for rheumatoid factor (RF), and 212 for 14-3-3 eta protein. Anti-CarP antibodies were measured using a fetal calf serum-based single-step assay (research use only, Inova Diagnostics, San Diego, CA). (3) Results: Anti-CarP antibodies were significantly higher and more frequent in anti-CCP3.1+ (<i>p</i> = 0.0025), RF+ (<i>p</i> = 0.0043) and 14-3-3 eta+ (<i>p</i> = 0.028) samples compared to the negative counterpart group. In addition, isolated anti-CarP positivity occurred in samples negative for anti-CCP3.1, RF, or 14-3-3 eta. When anti-CarP antibodies were compared to each of the RF, anti-CCP3.1, and 14-3-3 eta by receiver operating characteristic (ROC) analyses, the area under the curve (AUC) values of 0.71 (RF), 0.68 (anti-CCP3.1), and 0.59 (14-3-3 eta), respectively, demonstrated a moderate correlation. Using an UpSet plot, we determined that 10.6% of the samples with available results for anti-CCP3.1, RF, and anti-CarP showed triple positivity. (4) Conclusions: Anti-carbamylated protein (anti-CarP) antibodies can be detected in anti-CCP, RF and 14-3-3 eta-positive and -negative patients, potentially identifying specific subsets of patients.
Glyco-seek: Ultrasensitive Detection of Protein-Specific Glycosylation by Proximity Ligation Polymerase Chain Reaction (2016)

We report a non-destructive biochemical technique, termed "Glyco-seek", for analysis of O-GlcNAcylated proteins. Glyco-seek combines chemoenzymatic labeling, proximity ligation, and quantitative polymerase chain reaction to detect O-GlcNAcylated proteins with ultrahigh sensitivity. Our glycan-specific assay can be paired with traditional proximity ligation assays to simultaneously determine the change in total protein levels. We show that Glyco-seek detects attomoles of glycoproteins of interest from cell lysates, with sensitivity several orders of magnitude higher than that of current techniques. We used the method to directly assay the O-GlcNAcylation status of a low-abundance transcription factor from cell lysates without need for isolation or enrichment.
A Model-Driven Architecture Approach for Modeling, Specifying and Deploying Policies in Autonomous and Autonomic Systems (2006)

Autonomic computing (AC), self-management based on high level guidance from humans, is increasingly gaining momentum as the way forward in designing reliable systems that hide complexity and conquer IT management costs. Effectively, AC may be viewed as policy-based self-management. The model driven architecture (MDA) approach focuses on building models that can be transformed into code in an automatic manner. In this paper, we look at ways to implement policy-based self-management by means of models that can be converted to code using transformations that follow the MDA philosophy. We propose a set of UML-based models to specify autonomic and autonomous features along with the necessary procedures, based on modification and composition of models, to deploy a policy as an executing system
Ultrasonic time synchronization and ranging on smartphones (2015)

In this paper, we present the design and evaluation of a platform that can be used for time synchronization and indoor positioning of mobile devices. The platform uses the Time-Difference-Of-Arrival (TDOA) of multiple ultrasonic chirps broadcast from a network of beacons placed throughout the environment to find an initial location as well as synchronize a receiver's clock with the infrastructure. These chirps encode identification data and ranging information that can be used to compute the receiver's location. Once the clocks have been synchronized, the system can continue performing localization directly using Time-of-Flight (TOF) ranging as opposed to TDOA. This provides similar position accuracy with fewer beacons (for tens of minutes) until the mobile device clock drifts enough that a TDOA signal is once again required. Our hardware platform uses RF-based time synchronization to distribute clock synchronization from a subset of infrastructure beacons connected to a GPS source. Mobile devices use a novel time synchronization technique leverages the continuously free-running audio sampling subsystem of a smartphone to synchronize with global time. Once synchronized, each device can determine an accurate proximity from as little as one beacon using TOF measurements. This significantly decreases the number of beacons required to cover an indoor space and improves performance in the face of obstructions. We show through experiments that this approach outperforms the Network Time Protocol (NTP) on smartphones by an order of magnitude, providing an average 720μs synchronization accuracy with clock drift rates as low as 2ppm.
Multi-band low-noise microwave-signal-receiving system with a photonic frequency down-conversion and transfer-learning network (2021)

In this Letter, we propose and demonstrate a multi-band signal-receiving system, powered by photonic frequency down-conversion and transfer learning. A photonic frequency down-conversion system directly receives the microwave signals, and the transfer-learning network (TLN) lowers the noise in the signals. In addition to the effectiveness of denoising, the TLN also features ultra-fast retraining for signals of different types or different multi-band frequencies. Experimental results showed that the proposed microwave-signal-receiving system can improve the signal-to-noise (SNR) ratio of signals of different types, SNR, and duty cycles. For network retraining, the TLN requires only three times less data and 10 times less time consumption than conventional training methods.
Structure−Activity Relationships of <scp>l</scp>-Dioxolane Uracil Nucleosides as Anti-Epstein Barr Virus Agents (1999)

A series of 1,3-dioxolanyluracil analogues was prepared from the dioxolane intermediates 2, and their anti-Epstein Barr virus (anti-EBV) activities were determined. The potency of L-dioxolane uracil nucleosides against EBV replication is dependent on the substituents at the 5-position in the following decreasing order: I > Br > Cl > CH3 > CF3 > F. The most active and selective analogue was the iodo derivative (L-I-OddU) with an EC50 value of 0.03 microM and an EC90 value of 0.16 microM. There was no cytotoxicity or depletion of mitochondrial DNA in cells after exposure to L-I-OddU at 50 microM. The action against EBV replication in H1 cells is time-dependent, and EBV DNA in cells treated with L-I-OddU could rebound to pretreatment levels once the drug was removed. In view of the potent antiviral activity plus favorable toxicity profiles, L-I-OddU may be potentially useful for the treatment of EBV-related infectious diseases as well as for delaying the onset or decreasing the incidence of EBV-associated cancers.
ChemInform Abstract: SYNTHESIS OF CERTAIN (6:5:6) LINEAR TRICYCLIC NUCLEOSIDES AS POTENTIAL ANTITUMOR AGENTS (1981)

Abstract ö‐Amino‐thiosangivamycin (I) kondensiert mit Ameisensäureethylester zur Verbindung (IIa), die mit entsprechenden Bromiden zu den Thioethern (IIb) bis (IId) alkyliert wird.
Resolution enhancement in standing-wave total internal reflection microscopy: a point-spread-function engineering approach (2001)

The theoretical basis for resolution enhancement in standing-wave total internal reflection microscopy (SW-TIRM) is examined. This technique relies on the formation of an excitation field containing super-diffraction-limited spatial-frequency components. Although the fluorescence generated at the object planes contains high-frequency information of the object distribution, this information is lost at the image plane, where the detection optics acts as a low-pass filter. From the perspective of point-spread-function (PSF) engineering, one can show that if this excitation field is translatable experimentally, the high-frequency information can be extracted from a set of images where the excitation fields have different displacement vectors. We have developed algorithms to combine this image set to generate a composite image with an effective PSF that is equal to the product of the excitation field and the Fraunhofer PSF. This approach can easily be extended to incorporate nonlinear excitation modalities into SW-TIRM for further resolution improvement. We theoretically examine high-resolution imaging based on the addition of two-photon, pump-probe, and stimulated-emission depletion methods to SW-TIRM and show that resolution better than 1/20 of the emission wavelength may be achievable.
Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature (2005)

VE-cadherin is an adhesion molecule localized at the adherens junctions of endothelial cells. It is crucial for the proper assembly of vascular structures during angiogenesis and maintaining vascular integrity. We have studied 3 monoclonal antibodies (mAbs) against murine VE-cadherin that inhibit angiogenesis and tumor growth. Two of these, BV13 and 10G4, also disrupted normal vessels, resulting in severe vascular leakage, whereas the third, E4G10, did not. The goal of the current report was to identify the epitope of E4G10 and distinguish it from those of the disruptive mAbs. We mapped the epitope of E4G10 to within the first 10 amino acids of mature VE-cadherin and demonstrated that conserved tryptophan residues in this sequence are required for VE-cadherin-mediated trans-adhesion. The disruptive mAbs target a different epitope within amino acids 45 to 56, which structural homology modeling suggests is not involved in trans-adhesion. From our studies, we hypothesize that E4G10 can only bind the neovasculature, where VE-cadherin has not yet engaged in trans-adhesion and its epitope is fully exposed. Thus, E4G10 can inhibit junction formation and angiogenesis but is unable to target normal vasculature because its epitope is masked. In contrast, BV13 and 10G4 bind an epitope that is accessible regardless of VE-cadherin interactions, leading to the disruption of adherens junctions. Our findings establish the immediate N-terminal region of VE-cadherin as a novel target for inhibiting angiogenesis.
Optical properties of costal cartilage and their variation in the process of non-destructive action of laser radiation with the wavelength 1.56 μm (2014)

The optical properties of costal cartilage and their variation under the action of laser radiation with the wavelength are studied. The laser action regime corresponds to that used for changing the cartilage shape. The dynamics of the passed scattered laser radiation was studied by means of the optical fibre system, and the optical properties of the cartilage tissue (on the basis of Monte Carlo modelling of light propagation) – using the setup with two integrating spheres. Under the influence of radiation, the characteristics of which corresponded to those used for the cartilage shape correction, no essential changes in the optical parameters were found. The results obtained in the course of studying the dynamics of optical signals in the process of costal cartilage irradiation can be used for developing control systems, providing the safety and efficiency of laser medical technologies.
MicroRNA Profiling Reveals Distinct Mechanisms Governing Cardiac and Neural Lineage-Specification of Pluripotent Human Embryonic Stem Cells (2012)

Realizing the potential of human embryonic stem cells (hESCs) has been hindered by the inefficiency and instability of generating desired cell types from pluripotent cells through multi-lineage differentiation. We recently reported that pluripotent hESCs maintained under a defined platform can be uniformly converted into a cardiac or neural lineage by small molecule induction, which enables lineage-specific differentiation direct from the pluripotent state of hESCs and opens the door to investigate human embryonic development using in vitro cellular model systems. To identify mechanisms of small molecule induced lineage-specification of pluripotent hESCs, in this study, we compared the expression and intracellular distribution patterns of a set of cardinal chromatin modifiers in pluripotent hESCs, nicotinamide (NAM)-induced cardiomesodermal cells, and retinoic acid (RA)-induced neuroectodermal cells. Further, genome-scale profiling of microRNA (miRNA) differential expression patterns was used to monitor the regulatory networks of the entire genome and identify the development-initiating miRNAs in hESC cardiac and neural lineage-specification. We found that NAM induced nuclear translocation of NAD-dependent histone deacetylase SIRT1 and global chromatin silencing, while RA induced silencing of pluripotence-associated hsa-miR-302 family and drastic up-regulation of neuroectodermal Hox miRNA hsa-miR-10 family to high levels. Genome-scale miRNA profiling indentified that a unique set of pluripotence-associated miRNAs was down-regulated, while novel sets of distinct cardiac- and neural-driving miRNAs were up-regulated upon the induction of lineage-specification direct from the pluripotent state of hESCs. These findings suggest that a predominant epigenetic mechanism via SIRT1-mediated global chromatin silencing governs NAM-induced hESC cardiac fate determination, while a predominant genetic mechanism via silencing of pluripotence-associated hsa-miR-302 family and drastic up-regulation of neuroectodermal Hox miRNA hsa-miR-10 family governs RA-induced hESC neural fate determination. This study provides critical insight into the earliest events in human embryogenesis as well as offers means for small molecule-mediated direct control and modulation of hESC pluripotent fate when deriving clinically-relevant lineages for regenerative therapies.