gebhart/patrepeval huggingface dataset:
Energy conversion using thermoacoustic devices (2003)

Thermoacoustic engines offer the possibility for simple and efficient energy conversion devices. They can be prime movers where heat produces sound or heat pumps and refrigerators where sound pumps heat. An important element in such engines is the secondary thermodynamic medium, the stack which provide the phasing between heat transfer and pressure changes at acoustical frequencies. Other elements are a resonator, working fluid (usually a gas), heat exchangers and a driver or source of heat. Similar to thermoelectric devices, the engines require a temperature difference for their operation and when run in a conjugate mode they produce a temperature difference. They are interesting because they are simple and they have essentially no moving parts.
Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose (2021)

The safety of a novel modified-release oral capsule with orlistat and acarbose (MR-OA) was investigated in 67 obese middle-aged White men with a body mass index of 32 to 40 kg/m<sup>2</sup> or 30 to 32 kg/m<sup>2</sup> plus waist circumference >102 cm. The purpose of this investigation was to compare MR-OA with the existing conventional orlistat regarding systemic safety defined as plasma orlistat concentration at the end of the treatment period of 14 days. Participants took the MR-OA fixed-dose combination formulation 3 times a day together with a major meal. Three different doses of MR-OA were evaluated-60/20, 90/30, and 120/40 (mg orlistat/mg acarbose)-as well as 1 reference group who received the conventional orlistat, Xenical, with 120 mg of orlistat. Blood plasma was sampled on days 1 and 14. The orlistat plasma concentrations of the MR-OA dose showed a delayed absorption and were lower compared with conventional orlistat at the end of the study. All doses were safe and well tolerated without any unexpected adverse events and no serious adverse events. The delay in the rise of orlistat plasma concentration indicates that the modified-release properties of the MR-OA formulation are effective. The systemic exposure of orlistat resulting from MR-OA was similar, albeit a bit lower than the conventional orlistat with 120 mg of orlistat. We can therefore assume that the safety profile regarding the orlistat moiety of MR-OA is comparable to the conventional orlistat and a promising approach for weight control in obese patients. Further clinical evaluation is underway.
New radiosensitization treatment (KORTUC I) using hydrogen peroxide solution-soaked gauze bolus for unresectable and superficially exposed neoplasms (2008)

We developed a new radiosensitization treatment using a hydrogen peroxide solution (Oxydol)-soaked gauze named KORTUC I (Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas) for superficially exposed and unresectable neoplasms, such as malignant melanoma and malignant fibrous histiocytoma (MFH), based on our experimental results which demonstrated hydrogen peroxide as a strong radiosensitizer for the highly radioresistant osteosarcoma cell line, HS-Os-1. Five patients entered our clinical trial, one of whom had unresectable malignant melanoma; one, unresectable MFH; one, unresectable extramammary Paget's disease; one, locally advanced breast cancer and one with locally recurrent skin cancer. These patients were treated with radiation therapy using a high-energy electron beam from a linear accelerator. The total dose was 48 Gy, and each fraction size was 4 Gy. Radiation therapy for these patients was performed three times per week. Each time the radiation therapy was carried out, the superficially exposed tumors of these patients were covered with hydrogen peroxide solution (Oxydol)-soaked gauze, and the lesion was gently massaged for several minutes so as to allow the hydrogen peroxide solution to soak deeply into the tumor. In the treatment results, two of these five patients showed a clinically complete response (cCR) two to three months following the end of the KORTUC I radiosensitization treatment. The other three patients showed a clinically partial response (cCR) showing a decrement of more than half of the pretreatment volume. KORTUC I was completed without any severe complications, excluding mild radiation-induced dermatitis/mucositis (Grade I). In conclusion, this newly developed radiosensitization treatment using hydrogen peroxide solution (Oxydol)-soaked gauze for superficially exposed unresectable/radioresistant neoplasms appears to be an effective and valuable method of radiosensitization in terms of the blockade of anti-oxidative enzymes such as peroxidases, resulting in local oxygen production. Moreover, the KORTUC I radiosensitization treatment is relatively inexpensive and the method can therefore be utilized worldwide for many patients suffering from superficially exposed and locally advanced radioresistant neoplasms such as malignant melanoma, malignant fibrous histiocytoma (MFH) and various types of sarcomas.
Flexible Supercapacitor Made of Carbon Nanotube Yarn with Internal Pores (2013)

Electrochemical deposition of MnO2 onto carbon nanotube (CNT) yarn gives a high-performance, flexible yarn supercapacitor. The hybrid yarn's blended structure, resulting from trapping of MnO2 in its internal pores, effectively enlarges electrochemical area and reduces charge diffusion length. Accordingly, the yarn supercapacitor exhibits high values of capacitance, energy density, and average power density. Applications in wearable electronics can be envisaged.
1541 FRICTION BORING PROCESS FOR ALUMINUM ALLOYS (1998)

A friction boring process creates a corrosion resistant fine grain microstructure in the wall surfaces of holes bored in aluminum alloy materials. Arotating tool is inserted directly into the aluminum material. or into a pre-drilled pilot hole, at a sufficient rotational velocity and feed rate to cause working that extends beyond the diameter of the tool. frictional heating. and extraction of aluminum material by metal deformation rather than cutting action as with a conventional drill bit. Burring. smoothing, and otherwise removing aluminum material extracted from the hole may be performed by a finishing segment that limits insertion depth of the tool. Frictional heating generates a temperature suf- ficient for rapid recrystallization of the remaining worked metal to form a fine grain microstructure to a depth of about 2.5 mm in the hole surfaces. Corrosion protection is retained even if some fme grain material is removed during a subsequent reaming operation. Friction boring is fast, suit- able for a wide variety of aluminum alloy compositions, and easily adaptable to initial fabrication of aluminum compo- nents or to field repair of assembled structures such as on aging aircraft. The process creates a fine grain corrosion and fatigue resistant surface microstructure in aluminum alloy holes without the use of peening. heat treatments. or envi- ronmentally objectionable chemicals and coatings.
Targeted Surface Expression of an Exogenous Antigen in Stably Transfected Babesia bovis (2014)

Babesia bovis is a tick-borne intraerythocytic protozoan responsible for acute disease in cattle which can be controlled by vaccination with attenuated B. bovis strains. Emerging B. bovis transfection technologies may increase the usefulness of these live vaccines. One use of transfected B. bovis parasites may be as a vaccine delivery platform. Previous transfection methods for B. bovis were limited by single expression sites and intracellular expression of transfected antigens. This study describes a novel transfection system in which two exogenous genes are expressed: one for selection and the other for a selected antigen designed to be delivered to the surface of the parasites. The strategy for duplicating the number of transfected genes was based on the use of the putative bidirectional promoter of the B. bovis 1.4 Kb ef-1α intergenic region. The ability of this region to regulate two independent expression sites was demonstrated using a luciferase assay on transiently transfected B. bovis parasites and then incorporated into a stable transfection plasmid to control independent expression of the selectable marker GFP-BSD and another gene of interest. A chimeric gene was synthetized using sequences from the protective B-cell epitopes of Rhipicephalus microplus tick antigen Bm86 along with sequences from the surface exposed B. bovis major surface antigen-1. This chimeric gene was then cloned into the additional expression site of the transfection plasmid. Transfection of the B. bovis Mo7 strain with this plasmid resulted in stable insertion into the ef-1α locus and simultaneous expression of both exogenous genes. Expression of the Bm86 epitopes on the surface of transfected merozoites was demonstrated using immunofluorescence analyses. The ability to independently express multiple genes by the inclusion of a bidirectional promoter and the achievement of surface expression of foreign epitopes advances the potential of transfected B. bovis as a future vaccine delivery platform.
Automatic generation of semantic icon encodings for visualizations (2014)

Authors use icon encodings to indicate the semantics of categorical information in visualizations. The default icon libraries found in visualization tools often do not match the semantics of the data. Users often manually search for or create icons that are more semantically meaningful. This process can hinder the flow of visual analysis, especially when the amount of data is large, leading to a suboptimal user experience. We propose a technique for automatically generating semantically relevant icon encodings for categorical dimensions of data points. The algorithm employs natural language processing in order to find relevant imagery from the Internet. We evaluate our approach on Mechanical Turk by generating large libraries of icons using Tableau Public workbooks that represent real analytical effort by people out in the world. Our results show that the automatic algorithm does nearly as well as the manually created icons, and particularly has higher user satisfaction for larger cardinalities of data.
Computer-Generated Holograms as Generalized Optical Components (1975)

Information about arbitrarily shaped wavefronts can be recorded as computer-generated holograms. There are convenient techniques for producing image plane holograms consisting of many narrow fringes similar to interferograms. These diffractive filters are suitable for realization of generalized elements for use in optical systems. These holograms can be applied to accomplish phase transformations, geometrical transformations, and combinations of phase and geometrical transformations. Computer-generation of holograms allows introduction of general carrier configurations. Examples of circular carrier recordings are shown.
Identification of estrogenic tamoxifen metabolite(s) in tamoxifen-resistant human breast tumors. (1992)

These data suggest that cellular tamoxifen metabolism to estrogenic metabolites may in part contribute to stimulating the growth of hormone-responsive breast tumors following prolonged exposure to tamoxifen. Further evaluation of the relationship between cellular metabolism and acquired tamoxifen resistance is warranted.
Stochastic DT-MRI Connectivity Mapping on the GPU (2007)

We present a method for stochastic fiber tract mapping from diffusion tensor MRI (DT-MRI) implemented on graphics hardware. From the simulated fibers we compute a connectivity map that gives an indication of the probability that two points in the dataset are connected by a neuronal fiber path. A Bayesian formulation of the fiber model is given and it is shown that the inversion method can be used to construct plausible connectivity. An implementation of this fiber model on the graphics processing unit (GPU) is presented. Since the fiber paths can be stochastically generated independently of one another, the algorithm is highly parallelizable. This allows us to exploit the data-parallel nature of the GPU fragment processors. We also present a framework for the connectivity computation on the GPU. Our implementation allows the user to interactively select regions of interest and observe the evolving connectivity results during computation. Results are presented from the stochastic generation of over 250,000 fiber steps per iteration at interactive frame rates on consumer-grade graphics hardware.
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents (2006)

The nerve agents soman, sarin, VX, and tabun are deadly organophosphorus (OP) compounds chemically related to OP insecticides. Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inactivates the neurotransmitter acetylcholine. The limitations of available therapies against OP poisoning are well recognized, and more effective antidotes are needed. Here, we demonstrate that galantamine, a reversible and centrally acting AChE inhibitor approved for treatment of mild to moderate Alzheimer's disease, protects guinea pigs from the acute toxicity of lethal doses of the nerve agents soman and sarin, and of paraoxon, the active metabolite of the insecticide parathion. In combination with atropine, a single dose of galantamine administered before or soon after acute exposure to lethal doses of soman, sarin, or paraoxon effectively and safely counteracted their toxicity. Doses of galantamine needed to protect guinea pigs fully against the lethality of OPs were well tolerated. In preventing the lethality of nerve agents, galantamine was far more effective than pyridostigmine, a peripherally acting AChE inhibitor, and it was less toxic than huperzine, a centrally acting AChE inhibitor. Thus, a galantamine-based therapy emerges as an effective and safe countermeasure against OP poisoning.
Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B (1994)

Human neutrophils are highly responsive to the chemokine interleukin-8 (IL-8) owing to high levels of expression of two related receptors encoded by the single copy genes il8ra and il8rb located on chromosome 2q34-q35. To identify nuclear factors that regulate the expression of IL-8 receptors, we have first defined the organization of both genes and characterized their functional promoters. il8ra and il8rb span approximately 4 and 12 kilobase pairs of genomic DNA, respectively. In both cases, the open reading frame resides on a single exon. In contrast, the 5'-untranslated regions are more complex. For il8ra, it is formed from two exons, whereas for il8rb, seven distinct neutrophil mRNAs are formed by alternative splicing of 11 exons. One of the splice variants, designated IL8RB3, is the predominant form for il8rb. Two equally abundant mRNAs for il8ra, 2.0 and 2.4 kilobases in length, are expressed in neutrophils and arise from usage of two alternative polyadenylation signals. Primer extension analysis identified two major transcription start points for il8ra and 11 for il8rb. Regions extending 300 base pairs (bp) upstream from exon 1 of il8ra and 81 bp upstream from exon 3 of il8rb have limited sequence similarity but had strong constitutive promoter activity when cloned upstream from a chloramphenicol acetyltransferase-encoding reporter gene and transiently transfected into surrogate myeloid (HL-60, and U-937) and lymphoid (Jurkat) cell lines. Neither of these regions has sequences corresponding to classic promoter elements. In contrast, a region 643 base pairs upstream from exon 1 of il8rb had relatively low levels of constitutive promoter activity in all three cell environments, and a conserved TATA element is located 47 bp upstream of the 5'-end of exon 1. Thus, despite marked differences in the complexity of their genomic organization, il8ra and il8rb encode products that are similar in structure, function, and the major cell type of expression.
Clock synchronization using a linear process model (2005)

Abstract In this paper, we present a clock synchronization scheme based on a simple linear process model which describes the behaviors of clocks at a transmitter and a receiver. In the clock synchronization scheme, a transmitter sends explicit time indications or timestamps to a receiver, which uses them to synchronize its local clock to that of the transmitter. Here, it is assumed that there is no common network clock available to the transmitter and the receiver and, instead, the receiver relies on locking its clock to the arrival of the timestamps sent by the transmitter. The clock synchronization algorithm used by the receiver is based on a weighted least‐squares criterion. Using this algorithm, the receiver observes and processes several consecutive clock samples (timestamps) to generate accurate timing signals. This algorithm is very efficient computationally, and requires the storage of only a small number of clock samples in order to generate accurate timing signals. Copyright © 2006 John Wiley & Sons, Ltd.
Self-Assembly of Si Nanoparticles Produced by Aluminum-Induced Crystallization of Amorphous Silicon Film (2006)

Aluminum-induced crystallization of amorphous silicon (a-Si) was used to rapidly grow aluminum-doped silicon nanowires (SiNWs) that are parallel to the substrate surfaces on which they are grown. The study reveals that both aluminum thickness and native silicon oxide between Al and a-Si play critical roles in the formation of the nanostructures. The research results suggest that the rapid in-plane growth of these SiNWs can be attributed to self-assembly of nanosilicon islands, which is different from traditional SiNWs growth mechanisms such as vapor-liquid-solid.
Development of a rapid, cost-effective TaqMan Real-Time PCR Assay for identification and differentiation of<i>Coccidioides immitis</i>and<i>Coccidioides posadasii</i> (2010)

Coccidioidomycosis is an infection caused by Coccidioides immitis or C. posadasii. We developed a TaqMan real-time PCR assay that rapidly and accurately differentiates the species. This assay can be used as a tool to improve disease surveillance, increase understanding of the natural history of the infection, and assist in clinical differentiation studies.
New Methods for Developing and Manufacturing Compliant Mechanisms Utilizing Bulk Metallic Glass (2014)

Compliant mechanisms rely on the elastic bending of thin members to generate motion. In the paper by Homer, et al., bulk metallic glasses (BMGs) are shown to have an optimal combination of mechanical properties and processing ability, making them ideal for complex, low-cost compliant mechanisms.
Simple geometry gridless ion mirror (2000)

A gridless variation of the cylindrical ion mirror has been designed to create an electric field that is nonlinear in the axial direction and nearly homogeneous in the radial direction. The designs may include one or two chambers that consist of truncated cones. This new design concept yields ion mirrors with improved energy focusing over conventional single-field and multiple-field mirrors. Conventionally, ion mirrors with nonlinear field gradient use multiple diaphragm electrodes to which distinct voltages are applied. In this work, optimized nonlinear field distributions are achieved through shaping only two or three electrodes and applying only one or two voltages on the electrodes. The designs presented here offer high resolving power and low ion dispersion. SIMION simulations of performance from the ion source to the detector demonstrate resolving powers of 11,000 and 1,750 for ions with kinetic energy variations of 7.5% and 23.6%, respectively.
On-chip optical pumping of deep traps in AlGaN/GaN-on-Si power HEMTs (2015)

In this work, by using an on-chip Schottky-on-heterojunction light-emitting diode (SoH-LED) which is seamlessly integrated with the AlGaN/GaN high electron mobility transistor (HEMT), we studied the effect of on-chip light illumination on the de-trapping processes of electrons from both surface and bulk traps. Surface trapping was generated by applying OFF-state drain bias stress, while bulk trapping was generated by applying positive substrate bias stress. The de-trapping processes of surface and/or bulk traps were monitored by measuring the recovery of dynamic on-resistance Ron and/or threshold voltage Vth of the HEMT. The results show that the recovery processes of both dynamic Ron and threshold voltage Vth of the HEMT can be accelerated by the on-chip SoH-LED light illumination, demonstrating the feasibility of fully integrated opto-HEMTs to minimize the influences of traps during the dynamic operation of AlGaN/GaN power HEMTs.
Numerical analysis of magnetization of a bulk high T/sub c/ superconductor (1996)

Magnetization of a bulk high T/sub c/ superconductor (HTSC) is evaluated with the numerical simulation codes. The field-cooled magnetization of the HTSC is analyzed by using the critical state model. The pulse magnetization process is also analyzed by using the flux creep-flow model. The numerical solutions are discussed to clarify the time dependent effects in the reported experimental results on the pulse magnetization.
.sup.82 Sr-.sup.82 Rb Radioisotope generator (1976)

An improved .sup.82 Sr-.sup.82 Rb radioisotope generator system, based upon the complexing ion exchange resin Chelex-100, has been developed. Columns of this material can be easily and rapidly milked, and the Rb-Sr separation factor for a fresh generator was found to be > 10.sup.7. Approximately 80 percent of the .sup.82 Rb present was delivered in a 15-ml volume of aqueous 0.2 M NH.sub.4 Cl solution. After more than 6 liters of eluant had been put through the generator, the Rb-Sr separation factor was still observed to be > 10.sup.5, and no unusual strontium breakthrough behavior was seen in the system over nearly three .sup.82 Sr half lives.
Design of Potent Bivalent Thrombin Inhibitors Based on Hirudin Sequence: Incorporation of Nonsubstrate-Type Active Site Inhibitors (1994)

Hirudin from medicinal leech is the most potent and specific thrombin inhibitor from medicinal leech with a K(i) value of 2.2 x 10(-14) M. It consists of an active site blocking moiety, hirudin1-48, a fibrinogen-recognition exo-site binding moiety, hirudin55-65, and a linker, hirudin49-54, connecting these inhibitor moieties. Synthetic inhibitors were designed based on the C-terminal portion of hirudin. The bulky active site blocking moiety, hirudin1-48, was replaced by small nonsubstrate-type active site inhibitors of thrombin, e.g., dansyl-Arg-(D-pipecolic acid). The linker moiety was replaced by omega-amino acids of (12-aminododecanoic acid)-(4-aminobutyric acid), and hirudin55-65 was used as a fibrinogen-recognition exo-site binding moiety in most of the inhibitors. The crystal structure of the inhibitor in complex with human alpha-thrombin showed that dansyl, Arg, and D-pipecolic acid of the active site blocking moiety occupy S3, S1, and S2 subsites of thrombin, respectively, and were therefore designated as P3, P1, and P2 residues. The use of dansyl-Arg-(D-pipecolic acid) improved the affinity (K(i)) of the inhibitor 10-100-fold (down to 1.70 x 10(-11) M) compared to that of the similar compounds having D-Phe-Pro-Arg as their substrate-type inhibitor moiety (K(i) = 10(-9)-10(-10) M). The linker connected to P2 residue eliminated the scissile peptide bond. The inhibitor was also stable against human plasma proteases. Further inhibitor design revealed that the toxic dansyl group could be replaced by 4-tert-butylbenzenesulfonyl group and 1- or 2-naphthalenesulfonyl group for in vivo studies.(ABSTRACT TRUNCATED AT 250 WORDS)