gebhart/patrepeval huggingface dataset:
Review of MR elastography applications and recent developments (2012)

The technique of MR elastography (MRE) has emerged as a useful modality for quantitatively imaging the mechanical properties of soft tissues in vivo. Recently, MRE has been introduced as a clinical tool for evaluating chronic liver disease, but many other potential applications are being explored. These applications include measuring tissue changes associated with diseases of the liver, breast, brain, heart, and skeletal muscle including both focal lesions (e.g., hepatic, breast, and brain tumors) and diffuse diseases (e.g., fibrosis and multiple sclerosis). The purpose of this review article is to summarize some of the recent developments of MRE and to highlight some emerging applications.
Ghrelin secretion is inhibited by glucose load and insulin‐induced hypoglycaemia but unaffected by glucagon and arginine in humans (2004)

Ghrelin secretion in humans is inhibited by OGTT-induced hyperglycaemia and ITT but not by glucagon and arginine, two substances able to increase insulin and glucose levels. These findings question the assumption that glucose and insulin directly regulate ghrelin secretion. On the other hand, ghrelin secretion is not associated with the GH response to ITT or arginine, indicating that the somatotroph response to these stimuli is unlikely to be mediated by ghrelin.
Green Diesel from Kraft Lignin in Three Steps (2016)

Precipitated kraft lignin from black liquor was converted into green diesel in three steps. A mild Ni-catalyzed transfer hydrogenation/hydrogenolysis using 2-propanol generated a lignin residue in which the ethers, carbonyls, and olefins were reduced. An organocatalyzed esterification of the lignin residue with an in situ prepared tall oil fatty acid anhydride gave an esterified lignin residue that was soluble in light gas oil. The esterified lignin residue was coprocessed with light gas oil in a continous hydrotreater to produce a green diesel. This approach will enable the development of new techniques to process commercial lignin in existing oil refinery infrastructures to standardized transportation fuels in the future.
Characterization and modeling of accumulation-mode MOS varactors (2006)

The characterization and modeling of an accumulation-mode MOS varactor implemented in a standard 0.13 /spl mu/m CMOS process is discussed. An experimental model based on the physical parameters of the device is verified. The model has been extracted, using S-parameter measurements, from different MOS varactor structures and is valid in both accumulation and depletion regions. The model has been verified both directly using the extracted values and indirectly by comparing the measured and simulated tuning curves of 5-6 GHz voltage controlled oscillators designed in the same process.
Lateral energy band profile modulation in tunnel field effect transistors based on gate structure engineering (2012)

Choosing novel materials and structures is important for enhancing the on-state current in tunnel field-effect transistors (TFETs). In this paper, we reveal that the on-state performance of TFETs is mainly determined by the energy band profile of the channel. According to this interpretation, we present a new concept of energy band profile modulation (BPM) achieved with gate structure engineering. It is believed that this approach can be used to suppress the ambipolar effect. Based on this method, a Si TFET device with a symmetrical tri-material-gate (TMG) structure is proposed. Two-dimensional numerical simulations demonstrated that the special band profile in this device can boost on-state performance, and it also suppresses the off-state current induced by the ambipolar effect. These unique advantages are maintained over a wide range of gate lengths and supply voltages. The BPM concept can serve as a guideline for improving the performance of nanoscale TFET devices.
Phase measurement of a segmented wave front using PISton and TILt interferometry (PISTIL) (2018)

New architectures for telescopes or powerful lasers require segmented wave front metrology. This paper deals with a new interferometric wave front sensing technique called PISTIL (PISton and TILt), able to recover both piston and tilts of segment beams. The main advantages of the PISTIL technique are the absence of a reference arm and an access to the tilt information. An explanation of the principle, as well as an experimental implementation and the use of a segmented active mirror, are presented. Measurement errors of λ/200 for piston and 40 µrad for tilts have been achieved, well beyond performances requested for the above mentioned applications.
Anetumab Ravtansine: A Novel Mesothelin-Targeting Antibody–Drug Conjugate Cures Tumors with Heterogeneous Target Expression Favored by Bystander Effect (2014)

Mesothelin is a tumor differentiation antigen frequently overexpressed in tumors such as mesothelioma, ovarian, pancreatic, and lung adenocarcinomas while showing limited expression in nonmalignant tissues. Mesothelin is therefore an attractive target for cancer therapy using antibody-drug conjugates (ADC). This study describes the detailed characterization of anetumab ravtansine, here referred to as BAY 94-9343, a novel ADC consisting of a human anti-mesothelin antibody conjugated to the maytansinoid tubulin inhibitor DM4 via a disulfide-containing linker. Binding properties of the anti-mesothelin antibody were analyzed using surface plasmon resonance, immunohistochemistry, flow cytometry, and fluorescence microscopy. Effects of BAY 94-9343 on cell proliferation were first studied in vitro and subsequently in vivo using subcutaneous, orthotopic, and patient-derived xenograft tumor models. The antibody binds to human mesothelin with high affinity and selectivity, thereby inducing efficient antigen internalization. In vitro, BAY 94-9343 demonstrated potent and selective cytotoxicity of mesothelin-expressing cells with an IC(50) of 0.72 nmol/L, without affecting mesothelin-negative or nonproliferating cells. In vivo, BAY 94-9343 localized specifically to mesothelin-positive tumors and inhibited tumor growth in both subcutaneous and orthotopic xenograft models. In addition, BAY 94-9343 was able to induce a bystander effect on neighboring mesothelin-negative tumor cells. Antitumor efficacy of BAY 94-9343 correlated with the amount of mesothelin expressed and was generally superior to that of standard-of-care regimen resulting in complete tumor eradication in most of the models. BAY 94-9343 is a selective and highly potent ADC, and our data support its development for the treatment of patients with mesothelin-expressing tumors.
One meter to find them all-water network leak localization using a single flow meter (2014)

Leak localization is a major issue faced by water utilities worldwide. Leaks are ideally detected and localized by a network-wide metering infrastructure. However, in many utilities, in-network metering is minimally present at just the inlets of subnetworks called District Metering Area (DMA). We consider the problem of leak localization using data from a single flow meter placed at the inlet of a DMA. We use standard time-series based modeling to detect if a current meter reading is a leak or not, and if so, to estimate the excess flow. Conventional approaches use an a-priori fully calibrated hydraulic model to map the excess flow back to a set of candidate leak locations. However, obtaining an accurate hydraulic model is expensive and hence, beyond the reach of many water utilities. We present an alternate approach that exploits the network structure and static properties in a novel way. Specifically, we extend the use of centrality metrics to infrastructure domains and use these metrics to map from the excess leak flow to the candidate leak location(s). We evaluate our approach on benchmark water utility network topologies as well as on real data obtained from an European water utility. On benchmark topologies, the localization obtained by our method is comparable to that obtained from a complete hydraulic model. On a real-world network, we were able to localize two out of the three leaks whose data we had access to. Of these two cases, we find that the actual leak location was in the candidate set identified by our approach; further, the approach pruned as much as 78% of the DMA locations, indicating a high degree of localization.
Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR (2023)

CAR T cells recognizing CD19 effectively treat relapsed and refractory B-ALL and DLBCL. However, CD19 loss is a frequent cause of relapse. Simultaneously targeting a second antigen, CD22, may decrease antigen escape, but is challenging: its density is approximately 10-fold less than CD19, and its large structure may hamper immune synapse formation. The characteristics of the optimal CD22 CAR are underexplored. We generated 12 distinct CD22 antibodies and tested CARs derived from them to identify a CAR based on the novel 9A8 antibody, which was sensitive to low CD22 density and lacked tonic signaling. We found no correlation between affinity or membrane proximity of recognition epitope within Ig domains 3-6 of CD22 with CART function. The optimal strategy for CD19/CD22 CART co-targeting is undetermined. Co-administration of CD19 and CD22 CARs is costly; single CARs targeting CD19 and CD22 are challenging to construct. The co-expression of two CARs has previously been achieved using bicistronic vectors. Here, we generated a dual CART product by co-transduction with 9A8-41BBζ and CAT-41BBζ (obe-cel), the previously described CD19 CAR. CAT/9A8 CART eliminated single- and double-positive target cells in vitro and eliminated CD19<sup>-</sup> tumors in vivo. CAT/9A8 CART is being tested in a phase I clinical study (NCT02443831).
Increased Egg Production by Active Immunization against Vasoactive Intestinal Peptide in the Turkey (Meleagris gallopavo)1 (1995)

Vasoactive intestinal peptide (VIP) is a hypothalamic prolactin (PRL)-releasing factor in the turkey. The hypothesis in the present study was that active immunization of turkeys with VIP would neutralize endogenous VIP, decrease circulating PRI, and consequently prevent the expression of incubation behavior. Large white female turkeys were divided into three experimental groups comprising untreated controls, control turkeys immunized with keyhole limpet hemocyanin (KLH), and turkeys immunized with synthetic chicken VIP conjugate (KLH-cVIP). Each turkey received four injections at 4-wk intervals, starting on the day of photostimulation. The immune response, measured by the percentage binding of monoiodinated chicken VIP (cVIP) to plasma at a dilution of 1:1000, averaged 11.8 +/- 2.5% during the reproductive life cycle. Immunization against KLH-cVIP prevented the normal increases of PRL that are associated with the photo-induced reproductive cycle. Over a 21-wk period beginning at photostimulation, KLH-cVIP-immunized birds exhibited a maximal plasma PRL level of 82.2 +/- 29.5 ng/ml, compared to 367.7 +/- 66.6 ng/ml and 227.5 +/- 51.7 ng/ml for non- and KLH-immunized turkeys, respectively. The total number of nest visits per hen during the 147-day experimental period decreased from 320.0 +/- 48.2 in the nonimmunized controls to 180.7 +/- 53.7 and 149.4 +/- 13.1 visits in KLH- and KLH-cVIP conjugate-immunized turkeys. Turkeys that showed an immune response to KLH-cVIP immunization did not exhibit incubation behavior, whereas 54% and 33% of non- and KLH-immunized hens incubated their eggs.(ABSTRACT TRUNCATED AT 250 WORDS)
Stabilization of Hypersonic Boundary Layers by Porous Coatings (2001)

A second-mode stability analysis has been performed for a hypersonic boundary layer on a wall covered by a porous coating with equally spaced cylindrical blind microholes. Massive reduction of the second mode amplification is found to be due to the disturbance energy absorption by the porous layer. This stabilization effect was demonstrated by experiments recently conducted on a sharp cone in the T-5 high-enthalpy wind tunnel of the Graduate Aeronautical Laboratories of the California Institute of Technology. Their experimental confirmation of the theoretical predictions underscores the possibility that ultrasonically absorptive porous coatings may be exploited for passive laminar flow control on hypersonic vehicle surfaces.
Evolution of the Dmt-Tic Pharmacophore:  N-Terminal Methylated Derivatives with Extraordinary δ Opioid Antagonist Activity (1997)

The delta opioid antagonist H-Dmt-Tic-OH (2',6'-dimethyl-L-tyrosyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) exhibits extraordinary delta receptor binding characteristics [Ki delta = 0.022 nM; Ki mu/Ki delta = 150,000] and delta antagonism (pA2 = 8.2; Ke = 5.7 nM). A change in chirality of Dmt at C alpha (1, 2, 6, 8, 10, 13) curtailed delta receptor parameters, while replacement of its alpha-amino function by a methyl group (3) led to inactivity; Tyr-Tic analogues 4 and 11 weakly interacted with delta receptors. N-Alkylation of H-Dmt-Tic-OH and H-Dmt-Tic-Ala-OH with methyl groups produced potent delta-opioid ligands with high delta receptor binding capabilities and enhanced delta antagonism: (i) N-Me-Dmt-Tic-OH 5 had high delta opioid binding (Ki delta = 0.2 nM), elevated delta antagonism on mouse vas deferens (MVD) (pA2 = 8.5; Ke = 2.8 nM), and nondetectable mu activity with guinea pig ileum (GPI). (ii) N,N-Me2-Dmt-Tic-OH (12) was equally efficacious in delta receptor binding (Ki delta = 0.12 nM; Ki mu/Ki delta = 20000), but delta antagonism rose considerably (pA2 = 9.4; Ke = 0.28 nM) with weak mu antagonism (pA2 = 5.8; Ke = 1.58 microM; GPI/MVD = 1:5640). N-Me-(9) and N,N-Me2-Dmt-Tic-Ala-OH (15) also augmented delta opioid receptor binding, such that 15 demonstrated high affinity (Ki delta = 0.0755 nM) and selectivity (Ki mu/Ki delta = 20132) with exceptional antagonist activity on MVD (pA2 = 9.6; Ke = 0.22 nM) and weak antagonism on GPI (pA2 = 5.8; Ke = 1.58 microM; GPI/MVD = 1:7180). Although the amidated dimethylated dipeptide analogue 14 had high Ki delta (0.31 nM) and excellent antagonist activity (pA2 = 9.9; Ke = 0.12 nM), the increased activity toward mu receptors in the absence of a free acid function at the C-terminus revealed modest delta selectivity (Ki mu/Ki delta = 1655) and somewhat comparable bioactivity (GPI/MVD = 4500). Thus, the data demonstrate that N,N-(Me)2-Dmt-Tic-OH (12) and N,N-Me2-Dmt-Tic-Ala-OH (15) retained high delta receptor affinities and delta selectivities and acquired enhanced potency in pharmacological bioassays on MVD greater than that of other peptide or non-peptide delta antagonists.
Utilizing glottal source pulse library for generating improved excitation signal for HMM-based speech synthesis (2011)

This paper describes a source modeling method for hidden Markov model (HMM) based speech synthesis for improved naturalness. A speech corpus is first decomposed into the glottal source signal and the model of the vocal tract filter using glottal inverse filtering, and parametrized into excitation and spectral features. Additionally, a library of glottal source pulses is extracted from the estimated voice source signal. In the synthesis stage, the excitation signal is generated by selecting appropriate pulses from the library according to the target cost of the excitation features and a concatenation cost between adjacent glottal source pulses. Finally, speech is synthesized by filtering the excitation signal by the vocal tract filter. Experiments show that the naturalness of the synthetic speech is better or equal, and speaker similarity is better, compared to a system using only single glottal source pulse.
Performance of nanocrystalline iron pyrite as the back contact to CdS/CdTe solar cells (2014)

We describe the application of iron persulfide (pyrite, FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) NC thin films as a Cu-free back contact to CdS/CdTe solar cells. We synthesized cubic FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> NCs, and prepared NC-FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> films by drop-casting to investigate their use in thin film solar cells. Characterization of the FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> NC films revealed sub-band-gap optical absorption, holes as the majority carrier, free hole concentration of ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">19</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> , and Hall mobility of μ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">h</sub> <;<; 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> S <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . CdS/CdTe solar cells completed by depositing hydrazine-treated NC-FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> back contacts directly onto CdTe displayed efficiencies comparable to those of standard Cu/Au back contact devices. Our best FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> device shows an AM1.5G efficiency of 12.5%, V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> = 0.81 V, J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sc</sub> = 23.0 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and FF = 67%. Temperature dependent studies of solar cells reveal that the `roll-over' effect observed in standard devices at low temperature is controlled by replacing Cu by hydrazine-treated NC-FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> .
Keratin 8 Mutations in Patients with Cryptogenic Liver Disease (2001)

Mutations in the keratin 8 gene may predispose people to liver disease and may account for cryptogenic liver disease in some patients.
Ceramic Membranes for Novel Separations (1995)

Abstract A number of advances have been made in the fabrication and performance of supported ceramic membranes. Improvements in techniques for the synthesis of particulate sols containing particles in the range of 4 to 10 nm in diameter are discussed. Several deposition techniques for the fabrication of supported ceramic membranes via solgel technology are examined, including slipcasting, filtration, coating, and permformation. Supported titania membranes have been fabricated and both liquid phase permselectivity and gas phase permeability experiments have been performed. Results of the liquid phase separations indicate that these membranes are characterized by a molecular weight cutoff value of approximately 200. Gas phase permeabilities reveal that Knudsen diffusion is not the only mechanism of transport through these membranes.
Ultrafast magnetic resonance spectroscopic imaging using SPICE with learned subspaces (2019)

The proposed method enables ultrafast <sup>1</sup> H-MRSI of the brain using a learned subspace, eliminating the need of acquiring subject-dependent navigator data (known as <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>D</mml:mi><mml:mn>1</mml:mn></mml:msub></mml:math> ) in the original SPICE technique. It represents a new way to perform MRSI experiments and an important step toward practical applications of high-resolution MRSI.
B7 Costimulation Plays an Important Role in Protection from Herpes Simplex Virus Type 2-Mediated Pathology (2002)

We have used mice lacking both B7-1 and B7-2 costimulation molecules (B7KO) to investigate the effects of B7 costimulation on herpes simplex virus type 2 (HSV-2) pathogenesis. B7KO mice infected intravaginally with virulent HSV-2 showed more severe genital and neurologic disease and higher mortality rates than their wild-type counterparts. These results suggest that B7 costimulation molecules play an important role in the development of primary immune responses protective against HSV-2.
Surface characterization of cerium based conversion coatings (1999)

The goal of this research is to produce, characterize and evaluate coatings based on inorganic inhibitors which can serve as potential replacements for the chromated coatings currently used for corrosion protection in the aircraft industry. An inorganic cerium-based conversion coating has been developed and an invention disclosure has been made on the process. Panels survive over 336-hour salt fog testing at UMR and Boeing facilities which apparently meets the Mil Spec requirements for a conversion coating system. The cerium conversion coatings on aluminum7075 and 2024 panels were coated with a cathodic E-Coat. The panels that had been scribed, survived 2000 hours salt fog exposure.
Employing topic models for pattern-based semantic class discovery (2009)

A semantic class is a collection of items (words or phrases) which have semantically peer or sibling relationship. This paper studies the employment of topic models to automatically construct semantic classes, taking as the source data a collection of raw semantic classes (RASCs), which were extracted by applying predefined patterns to web pages. The primary requirement (and challenge) here is dealing with multi-membership: An item may belong to multiple semantic classes; and we need to discover as many as possible the different semantic classes the item belongs to. To adopt topic models, we treat RASCs as "documents", items as "words", and the final semantic classes as "topics". Appropriate preprocessing and postprocessing are performed to improve results quality, to reduce computation cost, and to tackle the fixed-k constraint of a typical topic model. Experiments conducted on 40 million web pages show that our approach could yield better results than alternative approaches.
High-efficiency thin-film GaAs solar cells. Interim report No. 1, 1 Jan--31 Mar 1976 (1976)

A program to develop gallium arsenide (GaAs) thin films with grain sizes suitable for low-cost high-efficiency solar cell application has been initiated. The approach is a recrystallization of evaporated thin germanium (Ge) films on low-cost metal substrates by means of scanning focused beams of energy using quartz-iodide lamps, lasers, and electron sources. The layer of Ge will then be used as a substrate for chemical vapor deposition of GaAs using either the organometallic or halide transport techniques. The materials cost of thin-film GaAs solar cells are predicted for a silicon steel substrate and a nickel/iron substrate. Also discussed is a design for the recrystallization apparatus, a low-cost profilometer which has been built for surface roughness and layer thickness measurements, a modification in the Vac-Ion evaporation system which allows a considerably higher throughput for AMOS solar cell fabrication and plans for the following period.