gebhart/patrepeval huggingface dataset:
Dimethylthiourea, an oxygen radical scavenger, protects isolated cardiac myocytes from hypoxic injury by inhibition of Na(+)-Ca2+ exchange and not by its antioxidant effects. (1992)

Myocardial reoxygenation injury may be attenuated by oxygen free radical scavengers, arguing for a role of oxygen radicals in this process. To determine whether free radical scavengers affect reoxygenation injury in isolated cardiac myocytes, resting rat ventricular myocytes were exposed to hypoxic (PO2 less than 0.02 mm Hg) glucose-free buffer alone (n = 50) or with the addition of the oxygen radical scavengers 1,3-dimethyl-2-thiourea (DMTU, 25 mM, n = 46), human recombinant superoxide dismutase (SOD, 1,000 units/ml, n = 40), or the combination of these agents (n = 41). All cells responded by undergoing contracture to a rigor form. Hypoxia was then continued for a second period (T2), the duration of which correlates inversely with survival. After reoxygenation, cells either retained their rectangular shape (survival) or hypercontracted to a rounded form (death). For the group of cells with a T2 period greater than 30 minutes, no cell exposed to buffer alone (n = 20) or to SOD (n = 16) survived, in contrast to 15 of 24 (63%) cells exposed to DMTU. The addition of SOD to DMTU offered no advantage to DMTU alone. The protective effect of DMTU was not observed when it was added at reoxygenation, suggesting that this agent has an important effect during the hypoxic period when intracellular Ca2+ is known to rise, most likely because of the reversal of Na(+)-Ca2+ exchange. Therefore, the effects of DMTU on Ca2+ regulation (indexed by indo-1 fluorescence) during hypoxia were studied. DMTU significantly blunted the [Ca2+] rise during the hypoxic period.(ABSTRACT TRUNCATED AT 250 WORDS)
Surface passivation oxide effects on the current gain of 4H-SiC bipolar junction transistors (2008)

Effects of surface recombination on the common emitter current gain have been studied in 4H-silicon carbide (SiC) bipolar junction transistors (BJTs) with passivation formed by conventional dry oxidation and with passivation formed by dry oxidation in nitrous oxide (N2O) ambient. A gradual reduction of the current gain was found after removal of the passivation oxide followed by air exposure. Comparison of the measurement results for two different passivated BJTs indicates that the BJTs with passivation by dry oxidation in nitrous oxide (N2O) ambient show a half order of magnitude reduction of base current, resulting in a half order of magnitude increase of current gain at low currents. This improvement of current gain is attributed to reduced surface recombination caused by reduced interface trap densities at the base-emitter junction sidewall.
CCNP Routing and Switching TSHOOT 300-135 Official Cert Guide (2014)

CCNP Routing and Switching TSHOOT 300-135 Official Cert Guide from Cisco Press allows you to succeed on the exam the first time and is the only self-study resource approvedby Cisco. Expert instructor Raymond Lacoste shares preparation hints and test-taking tips, helping you identify areas of weakness and improve both your conceptual knowledge and hands-on skills. This complete, official study package includes A test-preparation routine proven to help you pass the exam Do I Know This Already? quizzes, which allow you to decide how much time you need to spend on each section Chapter-ending exercises, which help you drill on key concepts you must know thoroughly The powerful Pearson IT Certification Practice Test software, complete with hundreds of exam-realistic questions, customization options, and detailed performance reports More than 60 minutes of personal video mentoring from the author on important exam strategies A trouble ticket chapter that explores ten additional network failures and the approaches you can take to resolve the issues presented A final preparation chapter, which guides you through tools and resources to help you craft your review and test-taking strategies Study plan suggestions and templates to help you organize and optimize your study time Well-regarded for its level of detail, study plans, assessment features, challenging review questions and exercises, this official study guide helps you master the concepts and techniques that ensure your exam success. CCNP Routing and Switching TSHOOT 300-135 Official Cert Guide is part of a recommended learning path from Cisco that includes simulation and hands-on training from authorized Cisco Learning Partners and self-study products from Cisco Press. To find out more about instructor-led training, e-learning, and hands-on instruction offered by authorized Cisco Learning Partners worldwide, please visit www.cisco.com. The official study guide helps you master topics on the CCNP Routing and Switching TSHOOT 300-135 exam, including how to troubleshoot: Device performance VLANs, Trunks, and VTP STP and Layer 2 Etherchannel Inter-VLAN routing and Layer 3 Etherchannel Switch security HSRP, VRRP, GLBP IPv4 and IPv6 addressing IPv4/IPv6 routing and GRE tunnels RIPv2, RIPng, EIGRP, and OSPF Route maps, policy-based routing, and route redistribution BGP Management protocols, tools, and access Companion CD-ROM The CD-ROM contains more than 200 practice questions for the exam, memory table exercises and answer keys, a study planner tool, and more than 60 minutes of video. Includes Exclusive Offer for 70% Off Premium Edition eBook and Practice Test Pearson IT Certification Practice Test minimum system requirements: Windows Vista (SP2), Windows 7, or Windows 8.1; Microsoft .NET Framework 4.5 Client; Pentium class 1GHz processor (or equivalent); 512 MB RAM; 650 MB disc space plus 50 MB for each downloaded practice exam; access to the Internet to register and download exam databases
Once More (1974)

Like when you are washing out a cup you've had flowers in.Someone brought
The many faces of SRPK1 (2016)

Serine-arginine protein kinase 1 (SRPK1) phosphorylates proteins involved in the regulation of several mRNA-processing pathways, including alternative splicing. SRPK1 has been recently reported to be overexpressed in multiple cancers, including prostate cancer, breast cancer, lung cancer, and glioma. Several studies have shown that inhibition of SRPK1 has anti-tumoural effects, and SRPK1 has therefore become a new candidate for targeted therapies. Interestingly, in terms of molecular mechanism, SRPK1 seems to act heterogeneously, and has been reported to affect several processes in different cancers, e.g. angiogenesis in prostate and colon cancer, apoptosis in breast and colon cancer, and migration in breast cancer. A recent report adds to this puzzle, showing that the main effect of SRPK1 overexpression in non-small-cell lung carcinoma is to stimulate a stem cell-like phenotype. This pleiotropy might be related to preferential activation of different downstream signalling pathways by SRPK1 in various cancers. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Nonradiative Dielectric Waveguide for Millimeter-Wave Integrated Circuits (1981)

A nonradiative dielectric waveguide is proposed in which dielectic strips are sandwiched between two parallel metal plates separated by a distance smaller than half a wavelength. Though the structure is substantially the same as that of the H-guide, it is based on a quite different principle of operation. This dielectric guide is particularly applicable in millimeter-wave integrated circuits, since it is not only small in size, but also allows bends and junctions to be incorporated into the circuits with very little radiation and interference. A design diagram is given. Losses and coupling coefficients of the strips are calculated, as well. Some basic circuit components, such as 90° and 180° bends and T-junctions, made of polystyrene strips, are measured to confirm their usefulness in millimeter-wave integrated circuits.
A Modular Architecture for Adaptive ChatBots (2011)

We illustrate an architecture for a conversational agent based on a modular knowledge representation. This solution provides intelligent conversational agents with a dynamic and flexible behavior. The modularity of the architecture allows a concurrent and synergic use of different techniques, making it possible to use the most adequate methodology for the management of a specific characteristic of the domain, of the dialogue, or of the user behavior. We show the implementation of a proof-of-concept prototype: a set of modules exploiting different knowledge representation techniques and capable to differently manage conversation features has been developed. Each module is automatically triggered through a component, named corpus callosum, whose task is to choose, time by time, the most adequate chatbot knowledge section to activate.
Vertical adiabatic transition between a silica planar waveguide and an electro-optic polymer fabricated with gray-scale lithography (2003)

We report on a vertical adiabatic transition between silica planar waveguides and electro-optic (EO) polymer. Gray-scale lithography was used to pattern a polymer transition with an exponential profile. Excess losses of the order of 1 dB were measured, and good mode matching to simulation was observed. This configuration, which married the advantages of both silica and EO-polymer planar-optic technologies, demonstrates a new technique for fabricating hybrid active devices with high modulation speed, low insertion loss, and complex geometries.
Stretchable metal films (2018)

The current growth of the wearable electronics market has inspired the development of soft and stretchable interfacing between electronics and the human body. Stretchable conductors are critical to the evolution of stretchable and wearable electronics. In this topical review, we discuss notable contributions to the field of stretchable metal films. Although the high conductivity of metals is an asset in electronic devices, their mechanical properties are not readily compatible with stretchable devices. We discuss the two main approaches to preserve conductivity during strain: conversion of stretching to bending strain and using topography to control cracking. These approaches lead to two contrasting electrical responses to mechanical deformation, and we discuss the application of these responses in devices as interconnects and sensors.
A facile synthesis of aminocarboxylic acid derivatives, new anti-ulcer agents. (1985)

3- [p-(trans-4-Aminomethylcyclohexylcarbonyl)phenyl] propionic acid hydrochloride (1a), a new anti-ulcer agent, was newly synthesized from trans- or mixed trans/cis-4-aminomethyl-cyclohexanecarboxylic acid and methyl 3-phenylpropionate (4) in three steps. Friedel-Crafts reaction of the acid chloride 3 and 4 was performed without any particular protection of the amino group of 3. 3- [p-(4-Aminomethylbenzoyl)phenyl] propionic acid hydrochloride (1b) was also obtained from 4-aminomethylbenzoic acid in a similar process.
Effective Generation of Test Sequences for Structural Testing of Concurrent Programs (2005)

One common approach to test sequence generation for structurally testing concurrent programs involves constructing a reachability graph (RG) and selecting a set of paths from the graph to satisfy some coverage criterion. It is often suggested that test sequence generation methods for testing sequential programs based on a control flow graph (CFG) can also be used to select paths from a RG for testing concurrent programs. However, there is a major difference between these two, as the former suffers from a feasibility problem (i.e., some paths in a CFG may not be feasible at run-time) and the latter does not. As a result, even though test sequence generation methods for sequential programs can be applied to concurrent programs, they may not be efficient. Moreover, in order to reduce testing effort and costs, it is important to reduce the number of test sequences being generated. Stated differently, we need methods which can generate efficient test sequences to increase the coverage in an effective way. We propose four different methods - two based on hot spot prioritization and two based on topological sort -to effectively generate a small set of test sequences that cover all the nodes in a RG. The same methods are also applied to the corresponding dual graph for generating test sequences to cover all the edges. A case study was conducted to demonstrate the use of our methods.
Design, processing and reliability characterizations of a 3D-WLCSP packaged component (2009)

Market demand is increasing for even higher packaging densities, smaller size, lower cost, and more heterogeneous functionality. As a result, three dimensional (3D) packaging has emerged as a leading packaging solution. This paper introduces a 3D Wafer Level CSP packaging architecture that provides a cost effective, rapid time to market alternative to emerging 3D die to wafer integration technologies. Focus is put on the design consideration and processing technologies of the 3D WLCSP including wafer level design rules, wafer level redistribution, wafer bumping, wafer thinning and dicing thinned wafers. The fabrication of test vehicles at the wafer level is discussed. The processing technologies discussed enable the 3D WLCSP with a low package stand off, small package footprint and high package density. Two levels of package interconnections for this 3D WLCSP are presented in this paper. The first level package is qualified by Air to Air Thermal Cycling (AATC) testing with very good reliability performance. The second level assembly shows robust yield on certain package structures. Manufacturing process challenges such as underfill encroachment, lead free CSP reflow profile setting, as well as different underfill methodologies are discussed.
New methods and reagents in organic synthesis. 83. Stereoselective total synthesis of AI-77-B, a gastroprotective substance from Bacillus pumilus AI-77 (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew methods and reagents in organic synthesis. 83. Stereoselective total synthesis of AI-77-B, a gastroprotective substance from Bacillus pumilus AI-77Yasumasa Hamada, Akiyoshi Kawai, Yasushi Kohno, Osamu Hara, and Takayuki ShioiriCite this: J. Am. Chem. Soc. 1989, 111, 4, 1524–1525Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/ja00186a071https://doi.org/10.1021/ja00186a071research-articleACS PublicationsRequest reuse permissionsArticle Views623Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Sequestering CO2 by Mineralization into Useful Nesquehonite-Based Products (2016)

The precipitation of magnesium hydroxy-carbonate hydrates has been suggested as a route to sequester CO2 into solids. We report the development of self-cementing compositions based on nesquehonite, MgCO3·3H2O, that are made from CO2-containing gas streams, the CO2 being separated from other gases by its high solubility in alkaline water, while magnesium is typically provided by waste desalination brines. Precipitation conditions are adjusted to optimize the formation of nesquehonite and the crystalline solid can readily be washed free of chloride. Products can be prepared to achieve self-cementation following two routes: (i) thermal activation of the nesquehonite then rehydration of the precursor or (ii) direct curing of a slurry of nesquehonite. The products thus obtained contain ~ 30 wt% CO2 and could form the basis for a new generation of lightweight, thermally insulating boards, blocks and panels, with sufficient strength for general construction.
Targeting Notch-1 positive acute leukemia cells by novel fucose-bound liposomes carrying daunorubicin (2016)

Complete remission by induction therapy in acute myelogenous leukemia (AML) can be achieved due to improvements in supportive and optimized therapy. However, more than 20% of patients will still need to undergo salvage therapy, and most will have a poor prognosis. Determining the specificity of drugs to leukemia cells is important since this will maximize the dose of chemotherapeutic agents that can be administered to AML patients. In turn, this would be expected to lead to reduced drug toxicity and its increased efficacy. We targeted Notch-1 positive AML cells utilizing fucose-bound liposomes, since activation of Notch-1 is required for O-fucosylation. Herein, we report that intravenously injected, L-fucose-bound liposomes containing daunorubicin can be successfully delivered to AML cells that express fucosylated antigens. This resulted in efficient tumor growth inhibition in tumor-bearing mice and decreased proliferation of AML patient-derived leukemia cells. Thus, biological targeting by fucose-bound liposomes that takes advantage of the intrinsic characteristics of AML cells could be a promising new strategy for Notch-1 positive-AML treatment.
Atomic layer deposition of ultrathin platinum films on tungsten atomic layer deposition adhesion layers: Application to high surface area substrates (2014)

Platinum (Pt) atomic layer deposition (ALD) usually yields Pt nanoparticles during initial film growth. In contrast, deposition of continuous and ultrathin Pt films is needed for many important applications, such as the oxygen reduction reaction in polymer electrolyte membrane (PEM) fuel cells. A continuous and high radius of curvature Pt film is more stable and has a higher area-specific activity than the Pt nanoparticles commonly used in PEM fuel cells. However, the Pt film must be ultrathin and have a large surface area to be cost effective. In this paper, a review of earlier Pt ALD studies on flat substrates is presented that demonstrates that tungsten, with a higher surface energy than platinum, can serve as an adhesion layer to achieve Pt ALD films that are continuous at ultrathin thicknesses of ∼1.5 nm. This work utilized MeCpPtMe3 and H2 plasma as the Pt ALD reactants. The deposition of continuous and ultrathin Pt ALD films using MeCpPtMe3 and H2 plasma as the reactants is then studied on two high surface area substrate materials: TiO2 nanoparticles and 3M nanostructured thin film (NSTF). Transmission electron microscopy (TEM) showed uniform and continuous Pt films with thicknesses of ∼4 nm on the TiO2 nanoparticles. TEM with electron energy loss spectroscopy analysis revealed W ALD and Pt ALD films with thicknesses of ∼3 nm that were continuous and conformal on the high aspect ratio NSTF substrates. These results demonstrate that cost effective use of Pt ALD on high surface area substrates is possible for PEM fuel cells.
Optically Transparent, Amphiphilic Networks Based on Blends of Perfluoropolyethers and Poly(ethylene glycol) (2008)

Amphiphilic networks of perfluoropolyethers (PFPE) and poly(ethylene glycol) (PEG) have been achieved to yield optically transparent, mechanically robust films over a wide range of compositions. Telechelic diols of these oligomers were transformed to a photocurable dimethacryloxy form (DMA) and free radically cured at various composition weight ratios to yield free-standing films. Clear and colorless amphiphilic networks could be achieved when low molar mass versions of both the PFPE-DMA (1 kg/mol) and the PEG-DMA (550 g/mol) were used. The bulk morphologies of the samples were extensively characterized by a variety of techniques including ultraviolet-visible spectroscopy, differential scanning calorimetry, dynamic mechanic thermal analysis, small-angle X-ray scattering, atomic force microscopy, X-ray photoelectron spectroscopy, and optical microscopy, which strongly suggest that nanoscopic to macroscopic phase-separated materials could be achieved. By incorporating a threshold amount of PFPEs into PEG-based hydrogel networks, water swelling could be significantly reduced, which may offer a new strategy for a number of medical device applications. Along these lines, strong inhibition of nonspecific protein adsorption could be achieved with these amphiphilic network materials compared with an oligo(ethylene glycol)-based self-assembled monolayer coated surface.
Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow (2014)

Single cell analysis of CTCs can demonstrate genotypic heterogeneity, changes over time, and discordance from DTCs and distant metastases. We present a cautionary case showing that CTCs from any single blood draw do not always reflect metastatic genotype, and that CTC and DTC analyses may provide independent clinical information. Isolated DTCs remain viable and can be propagated in culture while maintaining their original mutational status, potentially serving as a future resource for investigating new drug therapies.
Molecular cloning of a new receptor‐like kinase gene encoded at the <i>Lr10</i> disease resistance locus of wheat (1997)

More than 100 resistance genes against wheat rust pathogens have been described in wheat and its relatives. Although many of them have been extensively used in wheat resistance breeding, none of these resistance loci has yet been analyzed at the molecular level. By screening a set of near-isogenic lines carrying different leaf rust resistance genes with a wheat probe encoding a serine/ threonine protein kinase, we detected a polymorphic DNA fragment in the line with the Lr10 resistance gene. This fragment mapped to the Lr10 disease resistance locus and encodes a receptor-like protein kinase which we called LRK10. LRK10 contains a new type of extracellular domain not found in known plant or animal receptor kinases. Several conserved amino acids in S-domain glycoproteins and receptor-like kinases were also found in LRK10, suggesting that LRK10 and S-domain proteins belong to the same superfamily of specific recognition molecules in plants. Lrk10 was expressed at low levels in young seedlings and belongs to a gene family. Analysis of wheat lines with and without the Lr10 gene demonstrated that Lrk10 and Lr10 belong to the same genetic locus. We conclude that gene isolation based on protein kinase homology can identify new receptor domains and provide candidates for disease resistance genes in the complex wheat genome.