gebhart/patrepeval huggingface dataset:
Retinoic acid inhibition of serum-induced c-fos transcription in a fibrosarcoma cell line. (1992)

We investigated the mechanism by which retinoic acid causes growth arrest and flat reversion of SSV-NRK, simian sarcoma virus-transformed normal rat kidney cells. Northern analysis revealed that both chronic (7 days) and acute (6 h) retinoic acid treatment of serum-stimulated SSV-NRK cells caused a 6-fold decrease in c-fos mRNA levels. In addition, nuclear run-on experiments showed that retinoic acid regulated c-fos expression in SSV-NRK cells at the transcriptional initiation level. Attenuation of c-fos transcription was equal in both retinoic acid-treated and control cells, and no increased c-fos mRNA turnover was detected in retinoic acid-treated cells. Furthermore, there was no observed change in the c-fos mRNA levels after only 30 min of retinoic acid treatment, suggesting that a mechanism involving the interruption of the signal transduction mechanism at the membrane level is unlikely. Because it has been shown that c-fos expression plays a pivotal role in mitogenesis of quiescent fibroblasts, we conclude that the retinoic acid-mediated down-regulation of c-fos expression is a mechanism for growth inhibition in SSV-NRK cells.
A survey on automated dynamic malware-analysis techniques and tools (2008)

Anti-virus vendors are confronted with a multitude of potentially malicious samples today. Receiving thousands of new samples every day is not uncommon. The signatures that detect confirmed malicious threats are mainly still created manually, so it is important to discriminate between samples that pose a new unknown threat and those that are mere variants of known malware. This survey article provides an overview of techniques based on dynamic analysis that are used to analyze potentially malicious samples. It also covers analysis programs that leverage these It also covers analysis programs that employ these techniques to assist human analysts in assessing, in a timely and appropriate manner, whether a given sample deserves closer manual inspection due to its unknown malicious behavior.
Tuning the Band Gap of Graphene Nanoribbons Synthesized from Molecular Precursors (2013)

A prerequisite for future graphene nanoribbon (GNR) applications is the ability to fine-tune the electronic band gap of GNRs. Such control requires the development of fabrication tools capable of precisely controlling width and edge geometry of GNRs at the atomic scale. Here we report a technique for modifying GNR band gaps via covalent self-assembly of a new species of molecular precursors that yields n = 13 armchair GNRs, a wider GNR than those previously synthesized using bottom-up molecular techniques. Scanning tunneling microscopy and spectroscopy reveal that these n = 13 armchair GNRs have a band gap of 1.4 eV, 1.2 eV smaller than the gap determined previously for n = 7 armchair GNRs. Furthermore, we observe a localized electronic state near the end of n = 13 armchair GNRs that is associated with hydrogen-terminated sp(2)-hybridized carbon atoms at the zigzag termini.
Transthoracic ultrafast Doppler imaging of human left ventricular hemodynamic function (2014)

Heart diseases can affect intraventricular blood flow patterns. Real-time imaging of blood flow patterns is challenging because it requires both a high frame rate and a large field of view. To date, standard Doppler techniques can only perform blood flow estimation with high temporal resolution within small regions of interest. In this work, we used ultrafast imaging to map in 2-D human left ventricular blood flow patterns during the whole cardiac cycle. Cylindrical waves were transmitted at 4800 Hz with a transthoracic phased-array probe to achieve ultrafast Doppler imaging of the left ventricle. The high spatio-temporal sampling of ultrafast imaging permits reliance on a much more effective wall filtering and increased sensitivity when mapping blood flow patterns during the pre-ejection, ejection, early diastole, diastasis, and late diastole phases of the heart cycle. The superior sensitivity and temporal resolution of ultrafast Doppler imaging makes it a promising tool for the noninvasive study of intraventricular hemodynamic function.
Shape dimension and approximation from samples (2002)

There are many scientific and engineering applications where an automatic detection of shape dimension from sample data is necessary. Topological dimensions of shapes constitute an important global feature of them. We present a Voronoi based dimension detection algorithm that assigns a dimension to a sample point which is the topological dimension of the manifold it belongs to. Based on this dimension detection, we also present an algorithm to approximate shapes of arbitrary dimension from their samples. Our empirical results with data sets in three dimensions support our theory.
An Initial Lexicon for Sensory Properties of Dry Dog Food (2012)

Abstract A sensory lexicon for human description of the flavor, aroma, texture and appearance characteristics of dry dog food was developed using a consensus profile method. Twenty‐one products, available in the U . S . market, were studied. A five‐member highly trained descriptive sensory panel identified, defined and referenced more than 70 sensory attributes for this product category. The lexicon established included attributes common to most of the samples such as barnyard, brothy, brown, grain, soy, vitamin, off‐flavors oxidized oil, cardboard and stale, and attributes appropriate for only a few products such as liver, fish, burnt, spice brown, garlic, celery, clove and smoky. The product category often showed a blended sensory profile and overall impact was evaluated to better discriminate among the products. Practical Applications One of the most competitive and economically relevant industries of food processing is pet food production. Although there are physiological sensory differences among C anis familiaris and H omo sapiens , human sensory data can be useful for several purposes. This research provides a lexicon that can be used as a starting point to describe the appearance, texture, aroma and flavor characteristics of dry dog food products when such information is needed for quality control, shelf life, product development or claims substantiation. This information is useful to product developers, researchers and technologists in understanding these characteristics and using those attributes to improve dry dog food products.
Recent Advances in Fluorescent Probes for Monitoring of Hydrogen Sulfide (2013)

Hydrogen sulfide (H₂S), known for its unpleasant rotten egg smell and its high toxicity, has recently emerged as an important mediator of human physiological and pathological processes, such as the regulation of cell growth, cardiovascular protection, the stimulation of angiogenesis, gastric mucosal injury and Alzheimer's disease. Due to its significant actions in the physiology, H₂S has attracted the abundant concern of numerous researchers in the cutting edge of chemistry, biology and medicine. Recently, several fluorescent probes have been developed for detecting and elucidating the role played by H₂S in biological systems. This review highlights recent advances that have been made on the mechanism and applications of fluorescent probes for the detection of H₂S, demonstrating a new field in which remarkable improvements have been accomplished over the last two years.
Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity (1997)

The results do not support the view that inflammatory mechanisms in the synovial tissues of RA patients differ between early and late stages of the disease. The findings presented here are consistent with the concept that early RA is the result of a synovitis process of longer duration and that macrophage-derived cytokines play an important role in maintaining the clinical signs of inflammation.
One-pot synthesis of UiO-66@SiO<sub>2</sub> shell–core microspheres as stationary phase for high performance liquid chromatography (2014)

A facile one-pot synthesis of UiO-66@SiO<sub>2</sub> shell–core microspheres as HPLC stationary phase was reported.
Diagnostic Performance of Nanoparticle-Enhanced Magnetic Resonance Imaging in the Diagnosis of Lymph Node Metastases in Patients With Endometrial and Cervical Cancer (2005)

Lymph node characterization with USPIO increases the sensitivity of MRI in the prediction of lymph node metastases, with no loss of specificity. This may greatly improve preoperative treatment planning.
Efficient synthesis of 1-ethyl-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizine: a key precursor to eburnane alkaloids (1980)

B. Danieli, G. Lesma and G. Palmisano, J. Chem. Soc., Chem. Commun., 1980, 109 DOI: 10.1039/C39800000109
Has somethong changed here? Autonomous difference detection for security patrol robots (2007)

This paper presents a system for autonomous change detection with a security patrol robot. In an initial step a reference model of the environment is created and changes are then detected with respect to the reference model as differences in coloured 3D point clouds, which are obtained from a 3D laser range scanner and a CCD camera. The suggested approach introduces several novel aspects, including a registration method that utilizes local visual features to determine point correspondences (thus essentially working without an initial pose estimate) and the 3D-NDT representation with adaptive cell size to efficiently represent both the spatial and colour aspects of the reference model. Apart from a detailed description of the individual parts of the difference detection system, a qualitative experimental evaluation in an indoor lab environment is presented, which demonstrates that the suggested system is able register and detect changes in spatial 3D data and also to detect changes that occur in colour space and are not observable using range values only.
Remote Monitoring and Controlling System Based on ZigBee Networks (2013)

Thanks to the rapid development of information technology and the growth of the Internet through high speed networks, network environments have even been changed from office oriented environments based on business industries and public institutions to the interconnection of digital electronics in home networks. Home network based applications are very diverse and the remote monitoring and control areas have been studied. Recently, ZigBee has become one of the most promising technologies for home networks. ZigBee is a specification for a suite of networking, security and application software layers using small, low-power, low data rate communication technology based on IEEE 802.15.4 standard for personal area networks. Moreover, owing to the rapid growth of mobile technology, highperformance smartphones are widespread and in increasing cases are utilized as a terminal device. In this paper, we propose the design and implementation of a remote monitoring and controlling system using ZigBee networks. This system targets a home network. Web services and a smartphone are used for the client system to monitor and control the home.
α-Adducin Gly460Trp Polymorphism and Renal Hemodynamics in Essential Hypertension (2004)

Previous studies have shown an association between the alpha-adducin Gly460Trp polymorphism and salt-sensitive hypertension. Not much is known about the effects of the variants of this polymorphism on renal hemodynamics and function. Therefore, we performed the present study to investigate the effect of the 460Trp allele of the alpha-adducin gene on renal hemodynamics in one hundred and seventeen essential hypertensive patients who were put on a low and high sodium diet (randomized order). On the last day of each one-week dietary period, blood pressure, effective renal plasma flow (ERPF), glomerular filtration rate (GFR), and neurohormones were measured. Effective renal blood flow (ERBF), renal vascular resistance, and filtration fraction were calculated. ERPF, ERBF, and GFR were lower in patients homozygous for the 460Trp allele compared with patients with the Gly460Gly genotype on low sodium diet but no differences were found at the higher sodium intake. On the other hand, levels of atrial natriuretic peptide were significantly higher in patients with the Trp460Trp genotype as compared with patients with the Gly460Gly genotype on both diets. In multivariate analysis, Trp460Trp genotype, age, and mean arterial pressure were predictors of ERPF, whereas Trp460Trp genotype and age were predictors of GFR during the phase of low sodium diet. The present study shows that the Trp460Trp genotype is significantly associated with reduced renal plasma flow and glomerular filtration rate as compared with the wild-type variant.
The Cold Gas-Dynamic Spray and Characterization of Microcrystalline and Nanocrystalline Copper Alloys (2012)

Outstanding Thesis
Development countermeasures of China's renewable energy industry under the influence of financial crisis (2009)

The vigorous development and use of renewable energy is an important strategic choice to optimize the struction of energy resources, safeguard the security of energy resources, alleviate environment pollution and balance the development of energy, ecnomoy and environment. Based on the analysis of positive and negative impacts of financial crisis on Chinas renewable energy industry. some deveolpment countermeasures of this industry under the influence of financial crisis are proposed.
Effect of live yeast culture supplementation on hindgut microbial communities and their polysaccharidase and glycoside hydrolase activities in horses fed a high-fiber or high-starch diet (2009)

Four cecum and right ventral colon-fistulated horses were assigned in a 4 x 4 Latin square design and fed a high-fiber (HF) or a high-starch (HS) diet with or without 10 g of Saccharomyces cerevisiae (SC; CBS 493.94) containing 4.5 x 10(9) cfu/g. The HF and HS diets consisted of pelleted feeds and long wheat straw (18.0 and 3.5 g of DM.kg(-1) of BW.d(-1), respectively) given in 2 equal meals to provide an NDF:starch ratio of 3.5 and 1.0, respectively. After a 21-d adaptation period intestinal contents were collected 4 h after the morning meal on d 23 and 25 to determine bacterial and SC concentrations. Polysaccharidase activities (CMCase, xylanase, amylase) and activities of glycoside hydrolases (alpha-l-arabinosidase, beta-d-cellobiosidase, beta-d-glucosidase, beta-d-xylosidase) were determined in liquid-associated bacteria (LAB) and solid-adherent bacteria (SAB) isolated from both compartments. Lactobacilli were increased in the cecum (P = 0.012) and colon (P = 0.086) when starch intake increased, whereas total anaerobes, cellulolytics, and streptococci did not change in either compartment. In yeast-supplemented horses, SC concentrations were greater in cecum (4.4 x 10(6) cfu/mL) than in right-ventral colon (5.6 x 10(4) cfu/mL) and did no change with diet. Concentrations of lactobacilli and lactic-acid utilizers were greater (P = 0.099 and 0.067, respectively) in the cecum but remained similar in the colon of SC-supplemented horses. The CMCase activities of SAB were not affected by diet. Colonic xylanase activities of SAB were reduced (P = 0.046) by starch addition, but no change was seen in the cecum. All SAB glucoside hydrolase activities in the cecum and colon, except beta-d-xylosidase in the cecum, were decreased when starch intake was increased. The LAB CMCase (P = 0.049 in the colon) and xylanase (P = 0.021 in the cecum; P < 0.001 in the colon) activities decreased with starch intake. No effect of starch on LAB or SAB amylase activity was observed. Addition of SC improved SAB CMCase in the cecum (P = 0.019) and colon (P = 0.037) as well as beta-d-cellobiosidase (P = 0.002) and beta-d-glucosidase (P = 0.041) in the cecum. Only xylanase in the cecum (P = 0.015) and beta-d-xylosidase in the cecum (P = 0.028) were improved with SC, whereas colonic LAB alpha-amylase activity was significantly decreased (P = 0.046). Most enzymes involved in plant cell wall digestion were increased after SC addition. This fact may contribute to explain a better digestion of fiber that has been previously reported in SC-supplemented horses.
Cryosurgery: A review (2007)

Cryosurgery dates back to the 19th century, with the description of the benefits of local application of cooling for conditions such as pain control. Once commercial liquefied gases became available, more progress was made in the use of cryotherapy for localized lesions. As understanding of disease response to freezing increased, safer techniques for performing freezing procedures helped prepare its clinical application in different clinical situations, such as prostate disease and bronchial cancers. Cryosurgical techniques are less invasive and have lower morbidity compared with surgical resection. However, the use of cryosurgery has been limited by a lack of good understanding of the underlying mechanisms of tissue destruction. To apply cryosurgery clinically, and to extend its use, it is important to understand the mechanisms of freeze injury on cells, and to control the thermal parameters.
Human Immunodeficiency Virus Transactivator Protein (Tat) Stimulates Chemotaxis, Calcium Mobilization, and Activation of Human Polymorphonuclear Leukocytes: Implications for Tat‐Mediated Pathogenesis (2000)

The extracellular activities of the human immunodeficiency virus (HIV) transactivator protein (Tat) include induction of angiogenesis and stimulation of monocyte migration. Here it is shown that polymorphonuclear leukocytes (PMNL), mostly neutrophils, rapidly invade in response to Tat in vivo and initiate the formation of new vessels. In vitro, Tat was chemotactic for PMNL and induced calcium (Ca(2+)) mobilization. Tat proteins with inactivating substitutions in the arginine-glycine-aspartic acid or basic domain were still active in inducing PMNL migration, whereas Tat peptides mapped the migration and Ca(2+) mobilization activity to a cysteine-rich core domain, previously described as a Tat "chemokine-like" region (peptide CysL(24-51)). Tat and the CysL(24-51) peptide also induced PMNL superoxide production and the release of the angiogenic factors interleukin-8 and vascular endothelial growth factor from PMNL. CysL(24-51) did not induce endothelial cell migration but was angiogenic in vivo. These data indicate that the Tat activity on PMNL is mediated by its chemokine-like region and that PMNL recruitment by Tat is linked to angiogenesis.
Pegylation of poly(&gamma;-benzyl-L-glutamate) nanoparticles is efficient for avoiding mononuclear phagocyte system capture in rats (2010)

Poly(γ-benzyl-L-glutamate) (PBLG) derivatives are synthetic polypeptides for preparing nanoparticles with well controlled surface properties. The aim of this paper was to investigate the biodistribution of pegylated PBLG in rats. For this purpose, nanoparticles were prepared by a nanoprecipitation method using mixtures of different PBLG derivates, including a pegylated derivate to avoid mononuclear phagocyte system uptake. The morphology, size distribution, and surface charge of the nanoparticles were investigated as a function of the amount of polymer employed for the preparation. Moderately polydispersed nanoparticles (polydispersity index less than 0.2) were obtained. Their size increased with polymer concentration. The zeta potential values were negative whatever the formulations. The availability of polyethylene glycol chains on the nanoparticles' surface was confirmed by measuring the decrease in bovine serum albumin adsorption. For in vivo distribution studies, pegylated and nonpegylated nanoparticles were prepared with polymer mixtures containing PBLG-fluorescein isothiocyanate and imaged by fluorescence microscopy to measure their accumulation in liver and spleen tissues of rats after intravenous administration. Injection of stealth formulations resulted in negligible fluorescence in liver and spleen compared with nonpegylated formulations, which suggests that these nanoparticles are promising candidates as a stealth-type long-circulating drug carrier system and could be useful for active targeting of drugs while reducing systemic side effects.
Induction of Murine Mucosal CCR5-Reactive Antibodies as an Anti-Human Immunodeficiency Virus Strategy (2005)

The genital mucosa is the main site of initial human immunodeficiency virus type 1 (HIV-1) contact with its host. In spite of repeated sexual exposure, some individuals remain seronegative, and a small fraction of them produce immunoglobulin G (IgG) and IgA autoantibodies directed against CCR5, which is probably the cause of the CCR5-minus phenotype observed in the peripheral blood mononuclear cells of these subjects. These antibodies recognize the 89-to-102 extracellular loop of CCR5 in its native conformation. The aim of this study was to induce infection-preventing mucosal anti-CCR5 autoantibodies in individuals at high risk of HIV infection. Thus, we generated chimeric immunogens containing the relevant CCR5 peptide in the context of the capsid protein of Flock House virus, a presentation system in which it is possible to engineer conformationally constrained peptide in a highly immunogenic form. Administered in mice via the systemic or mucosal route, the immunogens elicited anti-CCR5 IgG and IgA (in sera and vaginal fluids). Analogous to exposed seronegative individuals, mice producing anti-CCR5 autoantibodies express significantly reduced levels of CCR5 on the surfaces of CD4+ cells from peripheral blood and vaginal washes. In vitro studies have shown that murine IgG and IgA (i) specifically bind human and mouse CD4+ lymphocytes and the CCR5-transfected U87 cell line, (ii) down-regulate CCR5 expression of CD4+ cells from both humans and untreated mice, (iii) inhibit Mip-1beta chemotaxis of CD4+ CCR5+ lymphocytes, and (iv) neutralize HIV R5 strains. These data suggest that immune strategies aimed at generating anti-CCR5 antibodies at the level of the genital mucosa might be feasible and represent a strategy to induce mucosal HIV-protective immunity.
Mechanisms of regulation and function of G-protein-coupled receptor kinases (2006)

G-protein-coupled receptor kinases (GRKs) interact with the agonist-activated form of G-protein-coupled receptor (GPCR) to affect receptor phosphorylation and to initiate profound impairment of receptor signaling, or desensitization. GPCR forms the largest family of cell surface receptors, and defects in GRK function have the potential consequence to affect GPCR-stimulated biological responses in many pathological situations.
A cross-layer approach for QoS topology control in wireless ad hoc networks (2009)

Wireless ad hoc networks using omni-directional antennas do not scale well due to interference between nearby nodes. Maintaining the QoS of the communications in this type of network is a difficult task. Using multiple narrow beam directional antennas alleviates this problem at the expense of connectivity. Multi-beam smart antennas allow the network topology to be adjusted dynamically by adjusting the beamwidth and beam directions to minimize interference and to maximize the number of possible concurrent network communications. This in turn helps to maintain the QoS of the communications. QoS routing has long been used to meet the user requirements by finding appropriate paths to the destinations. We extend this concept to create an adaptive QoS topology control (AQTC) system using smart antennas. We use a cross-layer approach to control the topology dynamically where the topology control layer sits between the MAC and the routing protocol. The performance of our protocol has been evaluated using extensive simulations. Simulation results show that different topologies for a set of communications perform differently. AQTC always forms a topology to facilitate the current communications and improves the network throughput and end-to-end delay.