gebhart/patrepeval huggingface dataset:
OFDM-Like Signaling for Broadband Satellite Applications: Analysis and Advanced Compensation (2017)

Orthogonal frequency-division multiplexing (OFDM), special form of multicarrier modulation, is the cornerstone of broad range of current standards. In addition, fifth-generation (5G) terrestrial wireless networks, advancing at accelerated speed, continue to use OFDM air interface. The first part of this paper endeavors to apply OFDM-like signaling for broadband satellite transmission in the forward direction, from gateway to terminals. Two layers of multicarrier operation are invoked. One allows multiple signals to share single on-board high-power amplifier. The other layer permits transmitted symbols from individual signals to modulate multiple narrowband OFDM subcarriers, followed by interpolating filters to suppress interference into adjacent signals and limit out-of-band emission to be compatible with satellite uplink. The second part of this paper proposes novel nonlinear compensation techniques, applied at the transmitter or receiver, and combination of both. Two performance assessments are provided: one exploiting information-theoretic framework using ideal channel coding; another based on total degradation using practical forward-error correction codes. We show that performance loss from nonlinear distortion can be significantly reduced when adopting the proposed correction methods. Furthermore, it is possible to use OFDM-like signaling over satellite, while being competitive, and in some cases surpassing, traditional systems with single-carrier modulation employing state-of-the-art enhanced receiver architecture.
755: Prognostic Value of Carbonic Anhydrase IX and KI67 as Predictors of Survival for Renal Clear Cell Carcinoma (2004)

You have accessJournal of UrologyDiscussed Poster, Monday, May 10, 2004, 8:00 am - 12:00 pm1 Apr 2004755: Prognostic Value of Carbonic Anhydrase IX and KI67 as Predictors of Survival for Renal Clear Cell Carcinoma Matthew H. Bui, David B. Seligson, Hyung L. Kim, Ken Han, Yunda Huang, Steve Horvath, Eric Stanbridge, Aarno Palotie, Robert A. Figlin, and Arie S. Belldegrun Matthew H. BuiMatthew H. Bui More articles by this author , David B. SeligsonDavid B. Seligson More articles by this author , Hyung L. KimHyung L. Kim More articles by this author , Ken HanKen Han More articles by this author , Yunda HuangYunda Huang More articles by this author , Steve HorvathSteve Horvath More articles by this author , Eric StanbridgeEric Stanbridge More articles by this author , Aarno PalotieAarno Palotie More articles by this author , Robert A. FiglinRobert A. Figlin More articles by this author , and Arie S. BelldegrunArie S. Belldegrun More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38004-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "755: Prognostic Value of Carbonic Anhydrase IX and KI67 as Predictors of Survival for Renal Clear Cell Carcinoma." The Journal of Urology, 171(4S), p. 200 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 200 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Matthew H. Bui More articles by this author David B. Seligson More articles by this author Hyung L. Kim More articles by this author Ken Han More articles by this author Yunda Huang More articles by this author Steve Horvath More articles by this author Eric Stanbridge More articles by this author Aarno Palotie More articles by this author Robert A. Figlin More articles by this author Arie S. Belldegrun More articles by this author Expand All Advertisement PDF downloadLoading ...
A High-Throughput Screening Assay for Inhibitors of Bacterial Motility Identifies a Novel Inhibitor of the Na<sup>+</sup>-Driven Flagellar Motor and Virulence Gene Expression in Vibrio cholerae (2011)

Numerous bacterial pathogens, particularly those that colonize fast-flow areas in the bladder and gastrointestinal tract, require motility to establish infection and spread beyond the initially colonized tissue. Vibrio cholerae strains of serogroups O1 and O139, the causative agents of the diarrheal illness cholera, express a single polar flagellum powered by sodium motive force and require motility to colonize and spread along the small intestine. Therefore, motility may be an attractive target for small molecules that can prevent and/or block the infective process. In this study, we describe a high-throughput screening (HTS) assay to identify small molecules that selectively inhibit bacterial motility. The HTS assay was used to screen an ∼8,000-compound structurally diverse chemical library for inhibitors of V. cholerae motility. The screen identified a group of quinazoline-2,4-diamino analogs that completely suppressed motility without affecting the growth rate in broth. A further study on the effects of one analog, designated Q24DA, showed that it induces a flagellated but nonmotile (Mot(-)) phenotype and is specific for the Na(+)-driven flagellar motor of pathogenic Vibrio species. A mutation conferring phenamil-resistant motility did not eliminate inhibition of motility by Q24DA. Q24DA diminished the expression of cholera toxin and toxin-coregulated pilus as well as biofilm formation and fluid secretion in the rabbit ileal loop model. Furthermore, treatment of V. cholerae with Q24DA impacted additional phenotypes linked to Na(+) bioenergetics, such as the function of the primary Na(+) pump, Nqr, and susceptibility to fluoroquinolones. The above results clearly show that the described HTS assay is capable of identifying small molecules that specifically block bacterial motility. New inhibitors such as Q24DA may be instrumental in probing the molecular architecture of the Na(+)-driven polar flagellar motor and in studying the role of motility in the expression of other virulence factors.
Resonantly Enhanced Multiphoton Ionization and Third-Harmonic Generation in Carbon Monoxide Gas* (1982)

Multiphoton ionization (MPI) and third-harmonic generation (THG) in gaseous carbon monoxide (CO) have been studied using photons generated from a Nd:YAG-pumped tunable dye laser (Quanta-Ray). The MPI and THG were studied in a static-gas ionization cell with a vacuum ultraviolet (VUV) radiation detector as shown in Fig. 1. In both experiments the dye laser output was focused to give a power density on the order of 10 9 W/cm 2 .
A novel ubiquitin‐specific protease, synUSP, is localized at the post‐synaptic density and post‐synaptic lipid raft (2003)

Recent reports suggest an important role for protein ubiquitination in synaptic plasticity. We cloned, from the rat brain, a novel gene that encoded an ubiquitin-specific protease (USP), and termed this protein synaptic ubiquitin-specific protease (synUSP, GenBankTM Accession no. AB073880). The homologous human gene was mapped to a locus on chromosome 1p36.12. The deduced synUSP protein consisted of 1036 amino acids, and possessed an ubiquitin-like domain at the C-terminus, Cys- and His-boxes, leucine zipper motifs, and six amino acid-repeats of L/ILCPHG. The protein possessed de-ubiquitinating activity toward a model substrate, as expected from its sequence. The protein of 125 kDa was present in the rat brain; in particular, it was enriched in the post-synaptic density and the dendritic lipid raft fractions. The immunostaining of cortical neurons confirmed the post-synaptic localization. The mRNA for synUSP was localized to dendrites, as well as somas, of neuronal cells. Thus, both the mRNA and the protein were localized in the post-synaptic compartments. These results suggest a regulatory mechanism for the ubiquitin-related system at the post-synaptic sites.
Immunohistologic Diagnosis of Sarcoidosis: Detection of Angiotensin-converting Enzyme in Sarcoid Granulomas (1981)

Angiotensin-converting enzyme (ACE) was detected by indirect immunofluorescence examination. ACE was present in the cytoplasm of epithelioid cells in granulomas from 38 of 39 patients who had clinical sarcoidosis but not in any of 37 nonsarcoid granulomas, normal lymph nodes, or splenic controls. Intensity of staining with ACE antiserum was inversely proportional to the degree of fibrosis and was significantly less intense in fibrotic granulomas. The detection of ACE appears to be a distinct aid in establishing a definitive tissue diagnosis of sarcoidosis.
Technetium-99m NGA functional hepatic imaging: preliminary clinical experience. (1985)

Technetium-99m galactosyl-neoglycoalbumin ( [Tc]NGA) is a radiolabeled ligand to hepatic binding protein, a receptor which resides at the plasma membrane of hepatocytes. This receptor-binding radiopharmaceutical and its kinetic model provide a noninvasive method for the assessment of liver function. Eighteen patients were studied: seven with hepatoma, eight with liver metastases, four with cirrhosis (two had concurrent hepatoma and one chronic active hepatitis), and one patient with acute fulminant non-A, non-B hepatitis. Technetium-99m NGA liver imaging provided anatomic information of diagnostic quality comparable to that obtained with other routine imaging modalities, including computed tomography, angiography, ultrasound, and [Tc]sulfur colloid scintigraphy. Kinetic modeling of dynamic [Tc]NGA data produced estimates of standardized hepatic blood flow, Q (hepatic blood flow divided by total blood volume), and hepatic binding protein concentration, [HBP]. Clinical correlation was by classical Child-Turcotte criteria (CTC). Significant rank correlation was obtained between [HBP] estimates and CTC scores (rs = -0.72, p = 0.001). This correlation supports the hypothesis that [HBP] is a measure of functional hepatocyte mass. The combination of decreased Q and markedly reduced [HBP] may have prognostic significance; all three patients with this combination died of hepatic failure within 6 wk of imaging.
Wide-Field Strain Imaging with Preferentially-Aligned Nitrogen-Vacancy Centers in Polycrystalline Diamond (2016)

We report on wide-field optically detected magnetic resonance imaging of nitrogen-vacancy centers (NVs) in type IIa polycrystalline diamond. These studies reveal a heterogeneous crystalline environment that produces a varied density of NV centers, including preferential orientation within some individual crystal grains, but preserves long spin coherence times. Using the native NVs as nanoscale sensors, we introduce a 3-dimensional strain imaging technique with high sensitivity ( $< 10^{-5}$ Hz$^{-1/2}$) and diffraction-limited resolution across a wide field of view.
Achieving full-color organic light-emitting devices for lightweight, flat-panel displays (1997)

We review recent results in the field of organic light-emitting devices (OLED's), with particular attention to the application of organic light-emitting devices to ultra-lightweight, full color, flat-panel displays. We show that OLED brightness, efficiency, operating voltage, and lifetime is sufficient to compete with other flat-panel display technologies such as backlit liquid crystal displays. We describe a novel, tunable OLED consisting of vertically stacked, transparent light-emitting devices which can serve as a color-tunable element in high-resolution full-color display., In addition, the unique physical properties of organic thin films allow for flexible, conformable, or foldable displays which are unobtainable with conventional, inorganic semiconductor technologies.
Anaerobic fermentation of glycerol by <i>Escherichia coli</i>: A new platform for metabolic engineering (2006)

The worldwide surplus of glycerol generated as inevitable byproduct of biodiesel fuel and oleochemical production is resulting in the shutdown of traditional glycerol-producing/refining plants and new applications are needed for this now abundant carbon source. In this article we report our finding that Escherichia coli can ferment glycerol in a pH-dependent manner. We hypothesize that glycerol fermentation is linked to the availability of CO(2), which under acidic conditions is produced by the oxidation of formate by the enzyme formate hydrogen lyase (FHL). In agreement with this hypothesis, glycerol fermentation was severely impaired by blocking the activity of FHL. We demonstrated that, unlike CO(2), hydrogen (the other product of FHL-mediated formate oxidation) had a negative impact on cell growth and glycerol fermentation. In addition, supplementation of the medium with CO(2) partially restored the ability of an FHL-deficient strain to ferment glycerol. High pH resulted in low CO(2) generation (low activity of FHL) and availability (most CO(2) is converted to bicarbonate), and consequently very inefficient fermentation of glycerol. Most of the fermented glycerol was recovered in the reduced compounds ethanol and succinate (93% of the product mixture), which reflects the highly reduced state of glycerol and confirms the fermentative nature of this process. Since glycerol is a cheap, abundant, and highly reduced carbon source, our findings should enable the development of an E. coli-based platform for the anaerobic production of reduced chemicals from glycerol at yields higher than those obtained from common sugars, such as glucose.
Synthesis and Characterization of Copolyimides with Varying Flexibilizing Groups (1985)

A series of polyimides and copolyimides with varying flexibilizing groups in their backbone were prepared. They were characterized in order to evaluate the effect of these groups on their rheological, mechanical, adhesive, and thermal properties. A copolymer with equimolar amounts of m-PDA and 4,4'-ODA exhibited the lowest viscosity at all strain rates studied. Since this particular polymer exhibited the best flow properties, it was also evaluated as an adhesive and was found to have exceptional characteristics for this application.
Oscillatory spin-orbit torque switching induced by field-like torques (2017)

Deterministic magnetization switching using spin-orbit torque (SOT) has recently emerged as an efficient means to electrically control the magnetic state of ultrathin magnets. The SOT switching still lacks in oscillatory switching characteristics over time, therefore, it is limited to bipolar operation where a change in polarity of the applied current or field is required for bistable switching. The coherent rotation based oscillatory switching schemes cannot be applied to SOT because the SOT switching occurs through expansion of magnetic domains. Here, we experimentally achieve oscillatory switching in incoherent SOT process by controlling domain wall dynamics. We find that a large field-like component can dynamically influence the domain wall chirality which determines the direction of SOT switching. Consequently, under nanosecond current pulses, the magnetization switches alternatively between the two stable states. By utilizing this oscillatory switching behavior we demonstrate a unipolar deterministic SOT switching scheme by controlling the current pulse duration.
An automatic power input control system in high frequency electric resistance welding. (1986)

It was found that monitoring the variation in oscillator frequency of welding current enables to detect the optimum welding state that produces the fewest weld defect. Applying this finding, new automatic power input control system was developed.This new system establishes and maintains the optimum welding state rapidly by the feed-forward system and precisely by the feed-back system. Besides the power input, other welding conditions were also optimized. Synthesizing these techniques, it has been possible to produce ERW pipes without weld defect.
Transcriptional Regulation of Tyrosine Phenol-Lyase Gene of<i>Erwinia herbicola</i>AJ2985 (1995)

Induction and repression of tyrosine phenol-lyase (TPL; EC 4.1.99.2) of Erwinia herbicola AJ2985 were examined on the transcriptional level and it was shown that transcription of tpl was increased by the addition of tyrosine and decreased by the addition of glucose in the medium. The 5' flanking region of its gene, tpl, was analyzed and its transcriptional start point was determined. A presumed -35, -10 promoter region, TyrR box, and operator-like region were also found in this region.
44.2: <i>Distinguished Paper</i> : Adaptive Contrast Enhancement for Digital Video (2007)

Abstract This paper describes a new real‐time adaptive contrast enhancement technique for digital video applications. The method is a modified contrast limited histogram equalization based procedure that adapts according to the input video statistics. The method decides whether to increase dynamic range or to light up dark regions of the image. As a result, for dark images, details in dark areas are enhanced without affecting mid and bright pixels. However for images with average brightness, the dynamic range of the scene is increased. It is adaptive and provides a localized contrast enhancement effect which is not possible with traditional contrast stretching/gamma LUT based approaches. Unlike traditional histogram equalization based approaches, the technique described automatically tones down its effects on pictures that are prone to contouring and other artifacts and is able to correctly enhance letter‐boxed as well as full‐screen video.
Development of Complexity Science and Technology Tools for NextGen Airspace Research and Applications (2012)

The objective of this research by NextGen AeroSciences, LLC is twofold: 1) to deliver an initial of algorithms, agent-based structures, and method descriptions for introducing trajectory agency as a methodology for simulating and analyzing airspace states, including bulk properties of large numbers of heterogeneous 4D aircraft trajectories in a test airspace -- while maintaining or increasing system safety; and 2) to use these tools in a test airspace to identify possible phase transition structure to predict when an airspace will approach the limits of its capacity. These 4D trajectories continuously replan their paths in the presence of noise and uncertainty while optimizing performance measures and performing conflict detection and resolution. In this approach, trajectories are represented as extended objects endowed with pseudopotential, maintaining time and fuel-efficient paths by bending just enough to accommodate separation while remaining inside of performance envelopes. This trajectory-centric approach differs from previous aircraft-centric distributed approaches to deconfliction. The results of this project are the following: 1) we delivered a toolbox of algorithms, agent-based structures and method descriptions as pseudocode; and 2) we corroborated the existence of phase transition structure in simulation with the addition of early warning detected prior to full airspace. This research suggests that airspace fullness can be anticipated and remedied before the airspace becomes unsafe.
Acoustic Classification and Optimization for Multi-Modal Rendering of Real-World Scenes (2017)

We present a novel algorithm to generate virtual acoustic effects in captured 3D models of real-world scenes for multimodal augmented reality. We leverage recent advances in 3D scene reconstruction in order to automatically compute acoustic material properties. Our technique consists of a two-step procedure that first applies a convolutional neural network (CNN) to estimate the acoustic material properties, including frequency-dependent absorption coefficients, that are used for interactive sound propagation. In the second step, an iterative optimization algorithm is used to adjust the materials determined by the CNN until a virtual acoustic simulation converges to measured acoustic impulse responses. We have applied our algorithm to many reconstructed real-world indoor scenes and evaluated its fidelity for augmented reality applications.
Biomedical applications of terahertz pulse imaging (2000)

We present Terahertz Pulse Imaging (TPI) results of different human tissue types. Our results are part of an initial study to explore the potential of TPI for biomedical applications. A survey of different tissue types has demonstrated the various contrast mechanisms that are available in TPI, allowing different tissue types to be readily identified. This encourages the pursuit of further studies of TPI for a variety of biomedical applications.
A Novel Laccase from the Ascomycete <i>Melanocarpus albomyces</i> (2003)

A novel laccase from the ascomycete Melanocarpus albomyces was isolated, purified and characterized. The ultraviolet-visible absorption and electron paramagnetic resonance spectra indicated that the three types of coppers were present. Redox potential of the T1 copper of M. albomyces laccase was determined to be 0.46±0.01 V. The enzyme had very interesting pH and temperature behaviour. It had a pH optimum measured with guaiacol at neutral and slightly alkalic pH and substantial activity still at pH 8. The laccase showed very good thermostability, retaining full activity for two hours at 60°C. The gene encoding the M. albomyces laccase was isolated and sequenced. The length of the open reading frame of the M. albomyces laccase was 623 amino acid residues. The copper binding residues were well conserved and the amino acid sequence had high homology to other ascomycete laccases. Interestingly the secreted laccase was processed both from the amino and carboxy terminus. The laccase was also crystallized with all four coppers present.
Efficient Transmitter Self-Calibration and Amplifier Linearization Techniques (2007)

This paper shows how RF circuit imperfections such as imbalances in the quadrature vector modulator and nonlinearities in the power amplifier can be effectively mitigated digitally at baseband. Two patented techniques, one for vector modulator calibration, and the other for power amplifier linearization, are described. Simulation and experimental results are included to demonstrate the performance improvement.
Laser transmitter for space-based sodium lidar instrument (2016)

We are currently developing a laser transmitter to remotely measure Sodium (Na) by adapting existing lidar technology with space flight heritage. The developed instrumentation will serve as the core for the planning of a Heliophysics mission targeted to study the composition and dynamics of Earth’s mesosphere based on a spaceborne lidar that will measure the mesospheric Na layer. We present performance results from our laser transmitter development effort with emphasis on wavelength tuning and power scaling of a diode-pumped Q-switched self-Raman c-cut Nd:YVO<sub>4</sub> laser with intra-cavity frequency doubling that could produce multi-watt 589 nm wavelength output. We will review technologies that provide strong leverage for the sodium lidar laser system with strong heritage from past and current space flight missions.