gebhart/patrepeval huggingface dataset:
Nitric oxide-induced headache in patients with chronic tension-type headache (2000)

An experimental model of headache offers unique possibilities to study the mechanisms responsible for head pain. Using the glyceryl trinitrate [GTN; nitric oxide (NO) donor] model of experimental headache, we studied the intensity, quality and time profile of headache after infusion of GTN in 16 patients with chronic tension-type headache and in 16 healthy controls. Subjects were randomized to receive intravenous infusion of GTN (0.5 microg/kg per minute for 20 min) or placebo on two headache-free days separated by at least 1 week. Headache intensity was measured on a 10-point verbal rating scale during 2 h of observation and for the next 10 h after discharge from hospital. The primary endpoints were the difference between the area under the curve (AUC-intensities x duration) for headache recorded on the day of GTN treatment and on the day of placebo treatment in patients, and in patients and controls on the days of GTN treatment. In patients, the AUC on a GTN day [2221 (1572-3704); median with quartiles in parentheses], was significantly greater than on a placebo day [730 (60-1678), P: = 0. 008]. On the GTN day, the AUC in patients [2221 (1572-3704)] was significantly higher than in controls [43 (0-972), P: = 0.0001]. In patients, peak pain intensity occurred 8 h after infusion of GTN, whereas in controls it occurred 20 min after the start of infusion. The present study demonstrates that an NO-induced biphasic response with an immediate and a delayed headache is common to chronic tension-type headache and migraine. Furthermore, the NO-induced delayed headache has the characteristics of the primary headache disorder. This suggests that NO contributes to the mechanisms of several types of primary headaches and that NO-related central sensitization may be an important common denominator in the pain mechanisms of primary headaches.
Enhanced antitumor properties of 3'-(4-morpholinyl) and 3'-(4-methoxy-1-piperidinyl) derivatives of 3'-deaminodaunorubicin (1982)

Reductive N,N-dialkylation of daunorubicin with 2,2'-oxydiacetaldehyde and NaBH3CN occurred in two steps without interruption and with cyclization to form 3'-(4-morpholinyl)-3'-deaminodaunorubicin. This derivative retained the antitumor efficacy of doxorubicin against mouse leukemia P388 but at one-fortieth the dose; hence, it is the most potent anthracycline analogue synthesized so far. The 4-methoxy-1-piperidinyl derivative, similarly prepared with 3-methoxyglutaraldehyde, showed improved efficacy against P388, though at normal doses. Results with a series of analogues indicate that incorporation of the N in the new ring and the presence of an ether O at the 4-position are critical for enhanced activity.
Novel Joint Sorting and Reduction Technique for Delay-Constrained LLL-Aided MIMO Detection (2008)

In this letter, we introduce a novel technique to speed up the famous LLL lattice reduction algorithm by use of sorting. Simulation results reveal that when applied to LLL-reduction-aided MIMO detectors, our proposed joint sorting and reduction technique can find an LLL-reduced basis with the average number of basis vector swappings reduced by about 47.5% for a 2 times 2 system and more for higher dimensional systems, without degrading the detection performance. Moreover, when the maximum number of vector swapping is limited, our proposed algorithm significantly outperform the conventional one at low-to-moderate bit error rates. This suggests that it can be applied advantageously to those MIMO systems with a strict delay constraint.
On the inversion of Mel-frequency cepstral coefficients for speech enhancement applications (2008)

The use of Mel-frequency cepstral coefficients (MFCCs) is well established in the fields of speech processing, particularly for speaker modeling within a Gaussian mixture model (GMM) speaker recognition system. The use of GMMs for speech enhancement applications has only recently been proposed in the literature; the concept of direct inversion of the MFCCs, however, has not been studied. In this paper we present a means to invert MFCCs for use in speech enhancement applications. Results for cepstral inversion is evaluated on the TIMIT speech corpus using perceptual evaluation of speech quality (PESQ).
Characterization of the anti-lethal factor (LF) antibody response in Anthrax Vaccine Adsorbed (AVA) individuals (132.15) (2009)

Abstract The currently licensed anthrax vaccine (AVA) has been designed to elicit primarily an anti-protective antigen response. However, animal studies have clearly demonstrated that antibodies to the lethal factor component of the toxin can provide protection against challenge. This study was designed to identify AVA vaccinated individuals that generate anti-LF responses and to determine if these anti-LF antibodies can mediate protection. Plasma was obtained from one thousand vaccinated individuals and thirty unvaccinated controls. Only 69 individuals (6.9%) had significant levels of anti-LF antibodies. The presence of these antibodies did not correlate with in vitro protection against lethal toxin. To determine if antibodies against specific regions of LF could mediate protection, we used overlapping decapeptides to identify six common antigenic regions within those individuals with high levels of anti-LF antibodies and high toxin neutralizing activity. Epitope-specific antibodies directed against three of these common antigenic regions were isolated and select antibodies were able to protect in both in vitro tissue culture and in vivo mouse toxin challenge models. Findings from these studies have important implications for vaccine design and immunotherapeutic development. NIAID: 5U19AI062629
Visual Object Recognition and Tracking of Tools (2011)

A method has been created to automatically build an algorithm off-line, using computer-aided design (CAD) models, and to apply this at runtime. The object type is discriminated, and the position and orientation are identified. This system can work with a single image and can provide improved performance using multiple images provided from videos. The spatial processing unit uses three stages: (1) segmentation; (2) initial type, pose, and geometry (ITPG) estimation; and (3) refined type, pose, and geometry (RTPG) calculation. The image segmentation module files all the tools in an image and isolates them from the background. For this, the system uses edge-detection and thresholding to find the pixels that are part of a tool. After the pixels are identified, nearby pixels are grouped into blobs. These blobs represent the potential tools in the image and are the product of the segmentation algorithm. The second module uses matched filtering (or template matching). This approach is used for condensing synthetic images using an image subspace that captures key information. Three degrees of orientation, three degrees of position, and any number of degrees of freedom in geometry change are included. To do this, a template-matching framework is applied. This framework uses an off-line system for calculating template images, measurement images, and the measurements of the template images. These results are used online to match segmented tools against the templates. The final module is the RTPG processor. Its role is to find the exact states of the tools given initial conditions provided by the ITPG module. The requirement that the initial conditions exist allows this module to make use of a local search (whereas the ITPG module had global scope). To perform the local search, 3D model matching is used, where a synthetic image of the object is created and compared to the sensed data. The availability of low-cost PC graphics hardware allows rapid creation of synthetic images. In this approach, a function of orientation, distance, and articulation is defined as a metric on the difference between the captured image and a synthetic image with an object in the given orientation, distance, and articulation. The synthetic image is created using a model that is looked up in an object-model database. A composable software architecture is used for implementation. Video is first preprocessed to remove sensor anomalies (like dead pixels), and then is processed sequentially by a prioritized list of tracker-identifiers.
Prospective and retrospective high order eddy current mitigation for diffusion weighted echo planar imaging (2013)

Purpose The proposed method is aimed at reducing eddy current (EC) induced distortion in diffusion weighted echo planar imaging, without the need to perform further image coregistration between diffusion weighted and T2 images. These ECs typically have significant high order spatial components that cannot be compensated by preemphasis. Theory and Methods High order ECs are first calibrated at the system level in a protocol independent fashion. The resulting amplitudes and time constants of high order ECs can then be used to calculate imaging protocol specific corrections. A combined prospective and retrospective approach is proposed to apply correction during data acquisition and image reconstruction. Results Various phantom, brain, body, and whole body diffusion weighted images with and without the proposed method are acquired. Significantly reduced image distortion and misregistration are consistently seen in images with the proposed method compared with images without. Conclusion The proposed method is a powerful (e.g., effective at 48 cm field of view and 30 cm slice coverage) and flexible (e.g., compatible with other image enhancements and arbitrary scan plane) technique to correct high order ECs induced distortion and misregistration for various diffusion weighted echo planar imaging applications, without the need for further image post processing, protocol dependent prescan, or sacrifice in signal‐to‐noise ratio. Magn Reson Med 70:1293–1305, 2013. © 2013 Wiley Periodicals, Inc.
An Agonist Murine Monoclonal Antibody to the Human c-Mpl Receptor Stimulates Megakaryocytopoiesis (1998)

Thrombopoietin (TPO) is a hematopoietic growth factor that stimulates megakaryocytopoiesis and platelet production in vivo and promotes the development of identifiable megakaryocytes in vitro. We have developed a murine monoclonal antibody, BAH-1, raised against human megakaryocytic cells, which specifically recognizes the c-Mpl receptor and shows agonist activity by stimulating megakaryocytopoiesis in vitro. BAH-1 antibody specifically binds to platelets and to recombinant c-Mpl with high affinity. Similar to TPO, BAH-1 alone supported the formation of colony-forming unit-megakaryocyte (CFU-MK) colonies. The combination of BAH-1 plus interleukin-3 or of BAH-1 plus human TPO significantly increased the number of human CFU-MK colonies. In addition, BAH-1 monoclonal antibody stimulated the proliferation and maturation of primary bone marrow megakaryocytes in a dynamic heterogeneous liquid culture system. Individual large megakaryocytes as well as small megakaryocytic cells were observed in cultures of CD34(+) CD41(+) cells in the presence of BAH-1 antibodies. Similar to TPO, BAH-1 antibody induced a significant response of murine immature megakaryocytes as observed by an increase in the detectable numbers of acetylcholinesterase-positive megakaryocytes. No effects of BAH-1 antibody were observed on colony-forming unit-granulocyte-macrophage, burst-forming unit-erythroid, or colony-forming unit-erythroid colonies. In vivo studies showed that BAH-1, alone or in combination with TPO, expands the numbers of megakaryocytic progenitor cells in myelosuppressed mice. This antibody should prove useful in understanding the structure-function aspects of the c-Mpl receptor as well as in evaluating the effects of the sustained activation of this receptor in preclinical models of severe thrombocytopenia.
High Temperature, Magnetic Field Assisted (sub)THz Quantum Cascade Laser (2009)

We demonstrate magnetic field assisted, (sub)THz quantum cascade laser operating above 200K. This is achieved through the application of strong magnetic fields which provide an additional lateral confinement in order to suppress non-radiative intersubband scattering.
Electrically Tunable Surface Micromachined Fabry-Perot interferometer for Visible Light (2009)

We present a new kind of electrostatically tunable surface micromachined Fabry-Perot interferometer (FPI) structure and a process flow which was successfully used to fabricate devices for visible wavelength range. The novel fabrication process is based on using polymeric sacrificial layer. Fabricated devices have five-layer dielectric mirrors made of atomic layer deposited Al2O3 and TiO2 thin films. An AC voltage control together with integrated series capacitance enable tuning range of the FPI etalon in excess of 60%. The FWHM (Full Width at Half Maximum) of the 4th order transmission is 5.4 nm with maximum transmission being about 67% at λ = 500 nm.
The Graft Tool: An All-Hexahedral Transition Algorithm for Creating a Multi-Directional Swept Volume Mesh (1999)

Sweeping algorithms have become very mature and can create a semi-structured mesh on a large set of solids. However, these algorithms require that all linking surfaces be mappable or submappable. This restriction excludes solids with imprints or protrusions on the linking surfaces. The grafting algorithm allows these solids to be swept. It then locally modifies the position and connectivity of the nodes on the linking surfaces to align with the graft surfaces. Once a high-quality surface mesh is formed on the graft surface, it is swept along the branch creating a 2 3/4-D mesh.
Monoclonal Antibodies That Inhibit the Transport Function of the 190-kDa Multidrug Resistance Protein, MRP (1999)

Multidrug resistance in tumor cells is often accompanied by overexpression of multidrug resistance protein (MRP), a 190-kDa transmembrane protein that belongs to the ATP-binding cassette superfamily of transport proteins. MRP mediates ATP-dependent transport of a variety of conjugated organic anions and can also transport several unmodified xenobiotics in a glutathione-dependent manner. To facilitate structure-function studies of MRP, we have generated a panel of MRP-specific monoclonal antibodies (mAbs). Four of these mAbs, QCRL-2, -3, -4, and -6, bind intracellular conformation-dependent epitopes, and we have shown that they can inhibit the transport of several MRP substrates. Binding competition and immunoprecipitation assays indicated that mAbs QCRL-4 and -6 probably recognize the same detergent-sensitive epitope in MRP, whereas mAbs QCRL-2, -3, and -4 each bind distinct, non-overlapping epitopes. Fab fragments inhibit transport as effectively as the intact mAbs, suggesting that inhibition results from direct interactions of the mAbs with MRP. Immunodot blot and immunoprecipitation analyses revealed that the minimal regions of MRP sufficient for full reactivity of mAbs QCRL-2 and -3 are amino acids 617-858 and 617-932, respectively, which encompass the NH2-proximal nucleotide-binding domain (NBD). In contrast, the epitope bound by mAb QCRL-4 localized to amino acids 1294-1531, a region that contains the COOH-proximal NBD. However, none of the mAbs inhibited photolabeling of intact MRP with 8-azido-[alpha-32P]ATP. This suggests that rather than preventing nucleotide binding, the mAbs inhibit transport by interfering with substrate binding or by trapping MRP in a conformation that does not allow transport to occur. Our results also demonstrate for the first time that the NBDs of MRP can be expressed as soluble polypeptides that retain a native conformation.
Insertable Surgical Imaging Device with Pan, Tilt, Zoom, and Lighting (2009)

In this paper we describe work we have done in developing an insertable surgical imaging device with multiple degrees of freedom for minimally invasive surgery. The device is fully insertable into the abdomen using standard 12 mm trocars. It consists of a modular camera and lens system which has pan and tilt capability provided by two small DC servo motors. It also has its own integrated lighting system that is part of the camera assembly. Once the camera is inserted into the abdomen, the insertion port is available for additional tooling, motivating the idea of single-port surgery. A third zoom axis has been designed for the camera as well, allowing close-up and far-away imaging of surgical sites with a single camera unit. In animal tests with the device we have performed surgical procedures including cholecystectomy, appendectomy, running (measuring) the bowel, suturing, and nephrectomy. Preliminary tests suggest that the new device may have advantages over a standard laparoscope including the following. • Low-cost and simple design. • Easier and more intuitive to use than a standard laparoscope. • Joystick operation requires no specialized operator training. • Pan/tilt functions provide a large imaging volume not restricted by the fulcrum point of standard laparoscope. • Time to perform procedures was better than or equivalent to a standard laparoscope. We believe these insertable platforms will be an integral part of future surgical systems. The platforms can be used with tooling as well as imaging devices, allowing many surgical procedures to be performed using such a system.
Block Copolymer−Ceramic Hybrid Materials from Organically Modified Ceramic Precursors (2001)

The study of amphiphilic polymer based functional organic−inorganic hybrid materials is an emerging research area offering enormous scientific and technological promise. Here, we show that employing poly(isoprene-block-ethylene oxide) block copolymers (PI-b-PEO) and a silicon precursor, which contains a polymerizable organic moiety, unprecedented morphology control on the nanoscale is obtained. This control is based on a unique polymer−ceramic interface, which is characterized using a multi-nuclei solid-state NMR approach. The results show that the hydrophilic parts of the polymer are completely integrated into the ceramic phase, thereby leading to a quasi “two-phase system”, allowing for a more rational hybrid morphology design based on the current understanding of the phase behavior of block copolymers and copolymer−homopolymer mixtures. Examination of the full phase space of the hybrid materials reveals the existence of a new bicontinuous cubic structure that was not known to exist in polymer systems. SAXS and TEM data of this structure are consistent with a so-called “Plumber's nightmare” morphology. Selective solvent swelling of the hydrophobic parts of the hybrids leads to isolated nano-objects of different shapes, sizes, and compositions, while heat treatment generates mesoporous ceramic materials in which the mesostructure of the precursor material is preserved. Potential applications of these materials ranging from nanobiotechnology to catalysis are discussed.
High-speed buffer management for 40 gb/s-based photonic packet switches (2006)

We develop a method of high-speed buffer management for output-buffered photonic packet switches. The use of optical fiber delay lines is a promising solution to constructing optical buffers. The buffer manager determines packet delays in the fiber delay line buffer before the packets arrive at the buffer. We propose a buffer management method based on a parallel and pipeline processing architecture consisting of (log/sub 2/N+1) pipeline stages, where N is the number of ports of the packet switch. This is an expansion of a simple sequential scheduling used to determine the delays of arriving packets. Since the time complexity of each processor in the pipeline stages is O(1), the throughput of this buffer management is N times larger than that of the sequential scheduling method. This method can be used for buffer management of asynchronously arriving variable-length packets. We show the feasibility of a buffer manager supporting 128 /spl times/ 40 Gb/s photonic packet switches, which provide at least eight times as much throughput as the latest electronic IP routers. The proposed method for asynchronous packets overestimates the buffer occupancy to enable parallel processing. We show through simulation experiments that the degradation in the performance of the method resulting from this overestimation is quite acceptable.
Nonlinear-carrier control for high-power-factor boost rectifiers (1996)

Novel nonlinear-carrier (NLC) controllers are proposed for high-power-factor boost rectifiers. In the NLC controllers, the switch duty ratio is determined by comparing a signal derived from the main switch current with a periodic, nonlinear carrier waveform. As a result, the average input current follows the input line voltage. The technique is suitable for boost converters operating in the continuous conduction mode. Input voltage sensing, the error amplifier in the current-shaping loop, and the multiplier/divider circuitry in the voltage feedback loop are eliminated. The current-shaping is based on switch (as opposed to inductor) current sensing. The NLC controllers offer comparable or improved performance over existing schemes, and are well suited for simple integrated-circuit implementation. Experimental verification on a 240 W rectifier is described.
Xlink-Identifier: An Automated Data Analysis Platform for Confident Identifications of Chemically Cross-Linked Peptides Using Tandem Mass Spectrometry (2010)

Chemical cross-linking combined with mass spectrometry provides a powerful method for identifying protein-protein interactions and probing the structure of protein complexes. A number of strategies have been reported that take advantage of the high sensitivity and high resolution of modern mass spectrometers. Approaches typically include synthesis of novel cross-linking compounds, and/or isotopic labeling of the cross-linking reagent and/or protein, and label-free methods. We report Xlink-Identifier, a comprehensive data analysis platform that has been developed to support label-free analyses. It can identify interpeptide, intrapeptide, and deadend cross-links as well as underivatized peptides. The software streamlines data preprocessing, peptide scoring, and visualization and provides an overall data analysis strategy for studying protein-protein interactions and protein structure using mass spectrometry. The software has been evaluated using a custom synthesized cross-linking reagent that features an enrichment tag. Xlink-Identifier offers the potential to perform large-scale identifications of protein-protein interactions using tandem mass spectrometry.
How should I interpret an interferon gamma release assay result for tuberculosis infection?: Table 1 (2013)

Current and planned clinical research will fill the gaps in the evidence-base, narrowing the areas of uncertainty and informing future policy. Translational research into next-generation IGRAs and new T cell-based diagnostic platforms will likely overcome the limitations of current IGRAs in the near future.
Conductive Polymer Cladding Layers for Waveguide Electro-Optic Modulators (2002)

Optical, electrical, processability, and film casting characteristics of various conductive cladding layers were investigated. The goal was to find conductive polymer cladding materials suitable for fabricating and optimizing waveguide electro-optic modulators. Using cladding material that is more conductive than the core material, the poling fields in the core will be maximized, realizing a maximum electro-optic coefficient, which reduces the operating voltage in waveguide electro-optic modulators. We found, however, that there are tradeoffs between absorption losses, conductivity, refractive index, materials processability and materials compatibility when using off-the-shelf materials.
Uniform 90-channel multiwavelength InAs/InGaAsP quantum dot laser (2007)

A 93-channel multiwavelength laser with maximum channel intensity non-uniformity of 3.0 dB over a wavelength range from 1638 to 1646 nm was demonstrated on the basis of a single 4500 µm-long InAs/InGaAsP quantum dot Fabry-Perot cavity chip. All channels were stable because of inhomogeneous gain broadening due to statistically distributed sizes and geometries of self-assembled quantum dots.