gebhart/patrepeval huggingface dataset:
Organisationsberatung — eine ‚unmögliche‘ Dienstleistung (2001)

TB.: Herr Wimmer, mit welchem Verstandnis von Organisation arbeiten Sie als systemischer Berater? R. W: Fur mich sind Organisationen ein ganz bestimmter Typus von sozialen Systemen, die sich um gesellschaftliche Problemstellungen herum ausbilden. Sie beziehen ihren Existenzgrund daraus, dass sie Leistungen fur ihr gesellschaftliches Umfeld erbringen. Modeme Gesellschaften haben in ihrer Evolution eine Komplexitatsstufe erreicht, auf der es Sinn macht, diesen Typus von sozialen Systemen zu kreieren. Modeme Gesellschaften stellen ein ganz besonderes, organisationsforderndes Milieu dar. Und dadurch, dass Organisationen nicht nur Probleme bearbeiten, sondern auch immer wieder Probleme aufwerfen, bieten sie wiederum Anlass, dass sich um diese ungelosten, quasi externalisierten Problemstellungen herum erneut Organisationen ausbilden. Organisationen bekommen ihren funktionalen Sinn in modemen Gesellschaften dadurch, dass sie Energien fur die Bewaltigung von Problemstellungen engfuhren konnen. Dabei sind sie meistens in Funktionssysteme der modernen Gesellschaft eingebettet, die als solche aber keine handlungsfahigen Einheiten sind und von daher Organisationen benotigen. Dieser Typus von sozialen Systemen, den wir Organisation nennen, gewinnt seine spezifische Art der internen Strukturierung und Prozessgestaltung aus den Charakteristika jener Leistungen, die er an seine Umwelt abgibt Produkte und Dienstleistungen im Falle von Unternehmen, gepruftes Wissen im Falle von Forschungseinrichtungen oder Rechtsen~wicklungen im Falle von Gerichten. Ausschlaggebend fur diese Prozesse der Leistungserbringung ist es, dass es gelingt, immer wieder von neuem Entscheidungen an Entscheidungen anzuschliesen. Entscheidungen sind also jene spezifischen Kommunikationsereignisse, mit deren Hil-
[The immunization effects of HBV core antigen and surface antigen fusion protein in mice]. (2009)

Compared to the recombinant fusion protein, the plasmid containing the chimeric gene of HBsAg and HBcAg is a more effective vaccine.
High Voltage 3D-Capacitor (2007)

In this work, we introduce a high voltage 3D-capacitor as a novel passive power device for a 400 V application. This device is realized in silicon technology which allows process reproducibility, high accuracy in capacitance values, and high quality of the dielectric layers (i.e., endurance at high electric field strengths). It can be manufactured discrete or as part of a monolithic integrated circuit. The outstanding properties of the device are a high ratio of capacitance value to consumed silicon area (capacitance enlargement of more than a factor of 16 in comparison to plane capacitors) and very stable capacitance values over a broad temperature range (i.e., average of 24 ppm/degC from 20-175degC).
The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity (2013)

An original, effective approach to the synthesis of natural and synthetic 5Z,9Z-dienoic acids in high yields (61-67%) and with high selectivity (>98%) was developed. The approach is based on the use of the new intermolecular catalytic cross cyclomagnesiation of terminal aliphatic and oxygenated 1,2-dienes upon treatment with Grignard reagents in the presence of the Cp2TiCl2 catalyst. High activity of (5Z,9Z)-5,9-eicosadienoic acid as a human topoisomerase I inhibitor at concentrations above 0.1 μM was elucidated.
Suprachoroidal delivery in a rabbit ex vivo eye model: influence of drug properties, regional differences in delivery, and comparison with intravitreal and intracameral routes. (2013)

The suprachoroidal route of injection allows localized delivery to the choroid-RPE and retina for small as well as large molecules. Suprachoroidal drug delivery to the vitreous declines with an increase in drug lipophilicity and molecular weight. Drug delivery differs between the dosed and opposite sides following suprachoroidal injection, at least up to 3 h.
Regulation of the Escherichia coli csgD promoter: interplay between five transcription factors (2010)

Under stressful conditions in nature, Escherichia coli forms biofilms for long-term survival. Curli fimbriae are an essential architecture for cell-cell contacts within biofilms. Structural components and assembly factors of curli are encoded by two operons, csgBA and csgDEFG. The csgD gene product controls transcription of both operons. Reflecting the response of csgD expression to external stresses, a number of transcription factors participate in the regulation of the csgD promoter. Analysis of the csgD mRNA obtained from E. coli mutants in different transcription factors indicated that CpxR and H-NS act as repressors while OmpR, RstA and IHF act as activators. An acid-stress response regulator, RstA, activates csgD only under acidic conditions. These five factors bind within a narrow region of about 200 bp upstream of the csgD promoter. After pair-wise promoter-binding assays, the increase in csgD transcription in the stationary phase was suggested to be due, at least in part, to the increase in IHF level cancelling the silencing effect of H-NS. In addition, we propose a novel regulation model of this complex csgD promoter through cooperation between the two positive factors (OmpR-IHF and RstA-IHF) and also between the two negative factors (CpxR-H-NS).
Synthesis and characterization of an acrylate pressure sensitive adhesive for transdermal drug delivery (2002)

Abstract The present investigation was directed towards the synthesis of a copolymer of 2‐ethylhexyl acrylate and acrylic acid to be exploited as a pressure sensitive adhesive (PSA) matrix in transdermal drug delivery systems. The polymer synthesis involved free radical solution polymerization using 2, 2′‐azobisisobutyronitrile as the free radical initiator. The experimental methodology involved the optimization of reaction conditions for the polymer synthesis. The optimized copolymer was then characterized by IR, 1 H‐NMR, DSC, GPC and XRD. The PSA was also evaluated for percent free monomer content, intrinsic viscosity, refractive index, moisture uptake potential and film forming properties. To assess it suitability in the development of transdermal systems, peel strength values with respect to release liner as well as human skin and skin irritation potential were also determined. In addition, wear performance test was conducted to evaluate adhesion and adhesive transfer. The synthesized adhesive was found to have good peel strength; exhibited excellent adhesion and adhesive transfer on removal. It was found suitable for use in transdermals and could be further exploited either as an adhesive matrix or as a system component in the area of transdermal drug delivery. Copyright © 2002 John Wiley & Sons, Ltd.
Electrooptic Modulation in Thin Film Barium Titanate Plasmonic Interferometers (2008)

We demonstrate control of the surface plasmon polariton wavevector in an active metal-dielectric plasmonic interferometer by utilizing electrooptic barium titanate as the dielectric layer. Arrays of subwavelength interferometers were fabricated from pairs of parallel slits milled in silver on barium titanate thin films. Plasmon-mediated transmission of incident light through the subwavelength slits is modulated by an external voltage applied across the barium titanate thin film. Transmitted light modulation is ascribed to two effects, electrically induced domain switching and electrooptic modulation of the barium titanate index.
Empirical evaluation of zero-admin authentication for vital sensors in body area networks (2008)

Authentication frameworks currently available in wireless networks, such as those in the IEEE802.15.4 security standard, are intended for applications in versatile sensor networks; however, both health care staff and medical professionals find it difficult to set them up. In addition, it is expected that these frameworks will increase computational burdens when applied to small vital sensors. It is therefore necessary to devise security arrangements that are easy to setup and consume less power for body area networks (BANs) consisting of vital sensors. In this paper, we evaluate our proposed zero-admin authentication system with reduced computational burden on a real vital sensor that has limited RAM/ROM and CPU power with a light-weight battery. Our proposed system expects a re-keying mechanism using vital data suitable for small sensors and uses one-way wireless communication for re-keying. The keys are kept their strength by infrequent updates of users' conditions. We discuss the protocol and then evaluate the re-keying mechanism with a typical cryptography on the real sensor device. Our evaluation shows the effectiveness of the proposed authentication system for practical use and raises additional issues that must be resolved for improved performance.
Separate MRI quantification of dispersed (ferritin‐like) and aggregated (hemosiderin‐like) storage iron (2010)

A new MRI method is proposed for separately quantifying the two principal forms of tissue storage (nonheme) iron: ferritin iron, a dispersed, soluble fraction that can be rapidly mobilized, and hemosiderin iron, an aggregated, insoluble fraction that serves as a long-term reserve. The method utilizes multiple spin echo sequences, exploiting the fact that aggregated iron can induce nonmonoexponential signal decay for multiple spin echo sequences. The method is validated in vitro for agarose phantoms, simulating dispersed iron with manganese chloride, and aggregated iron with iron oxide microspheres. To demonstrate feasibility for human studies, preliminary in vivo data from two healthy controls and six patients with transfusional iron overload are presented. For both phantoms and human subjects, conventional R(2) and R(2)* relaxation rates are also measured in order to contrast the proposed method with established MRI iron quantification techniques. Quantification of dispersed (ferritin-like) iron may provide a new means of monitoring the risk of iron-induced toxicity in patients with iron overload and, together with quantification of aggregated (hemosiderin-like) iron, improve the accuracy of estimates for total storage iron.
Improvement of the performance of particulate phthalocyanine photovoltaic cells by the use of polar polymer binders (1983)

Effects of binder polymers on the performance of phthalocyanine photovoltaic cells have been investigated. The cells were fabricated by dispersing metal-free phthalocyanine fine particles in a binder polymer and sandwiching them between aluminum and In2O3 electrodes. Polymers such as poly (vinylidene fluoride), poly (vinyl fluoride), polyacrylonitrile, poly (4-vinylpyridine), poly (p-vinyl phenol), and poly (vinylidene chloride) were found to give a larger photocurrent and a higher conversion efficiency than did others. This is attributable to the enhancement of exciton dissociation due to a large electric field formed by the presence of polar groups in these polymers. An estimation based on a simple assumption showed that an electric field as high as 106 V/cm may be produced in the microenvironment of a photoactive site, strong enough to induce such an effect.
Growth of <i>Listeria monocytogenes</i> at refrigeration temperatures (1990)

The growth of three strains of Listeria monocytogenes at refrigeration temperatures (-0.5 to 9.3 degrees C) in chicken broth and/or UHT milk was determined using a rocking temperature gradient incubator. Minimum growth temperatures ranged from -0.1 to -0.4 degree C for the three strains. Lag times of 1-3 d and 3 to greater than 34 d were observed with incubation at 5 and 0 degrees C respectively. Corresponding generation times ranged from 13-24 h at 5 degrees C and 62-131 h at 0 degree C. The type of culture medium had an influence on both the rate and extent of growth. Incubation of cultures at 4 degrees C before inoculation caused a marked reduction in the lag time when compared with cultures which had been previously incubated at 30 degrees C.
Dependency of BET surface area on particle size for some granitic minerals (2011)

Abstract In order to assess the geochemical retention properties of rocks, which will be the final barrier for radionuclide transport to the biosphere in the case of a failed deep underground repository for spent nuclear fuel, radionuclide sorption experiments are usually made with crushed material. This raises the issue of extrapolating results obtained from laboratory experiments to the field scale. As sorption is generally related to the surface area of the geological material, it is then important to consider the dependency of the specific surface area on the particle size. In this work, BET surface area determinations of samples of different particle sizes are conducted on two minerals commonly found in granite: labradorite and magnetite. The results show a linear relationship between BET surface area and the inverse of the particle size, up to a certain particle size. Furthermore, results also show that the specific surface area for intact, larger pieces is much smaller than the one predicted by a linear extrapolation of results on crushed material. Therefore, extrapolation of BET area for fine particles to the field situation will lead to an overestimation of the surface area and thereby also the radionuclide sorption, if sorption coefficients are extrapolated as well. Also of importance is that these results show that sorption experiments on crushed material may dominantly reflect properties of new surface, created during the mechanically treatment of the samples.
Development of the cardiovascular system: an interactive video computer program. (1992)

The major aim of this project is to provide interactive video computer based courseware that can be used by the medical student and others to supplement his or her learning of this very important aspect of basic biomedical education. Embryology is a science that depends on the ability of the student to visualize dynamic changes in structure which occur in four dimensions--X, Y, Z, and time. Traditional didactic methods, including lectures employing photographic slides and laboratories employing histological sections, are limited to two dimensions--X and Y. The third spatial dimension and the dimension of time cannot be readily illustrated using these methods. Computer based learning, particularly when used in conjunction with interactive video, can be used effectively to illustrate developmental processes in all four dimensions. This methodology can also be used to foster the critical skills of independent learning and problem solving.
LIF detection of peptides and proteins in CE (2006)

CE- and microchip-based separations coupled with LIF are powerful tools for the separation, detection and determination of biomolecules. CE with certain configurations has the potential to detect a small number of molecules or even a single molecule, thanks to the high spatial coherence of the laser source which permits the excitation of very small sample volumes with high efficiency. This review article discusses the use of LIF detection for the analysis of peptides and proteins in CE. The most common laser sources, basic instrumentation, derivatization modes and set-ups are briefly presented and special attention is paid to the different fluorogenic agents used for pre-, on- and postcapillary derivatization of the functional groups of these compounds. A table summarizing major applications of these derivatization reactions to the analysis of peptides and proteins in CE-LIF and a bibliography with 184 references are provided which covers papers published to the end of 2005.
First-line treatment of acute lymphoblastic leukemia with pegasparaginase (2009)

First-line treatment of acute lymphoblastic leukemia with pegasparaginase Riccardo Masetti, Andrea PessionPediatric Oncology and Hematology Unit “Lalla Seràgnoli”, University of Bologna, Bologna, ItalyAbstract: Acute lymphoblastic leukemia (ALL) accounts for almost 4000 cases annually in the United States, approximately two thirds of which are in children and adolescents. Treatment results of ALL have improved considerably in the past decade, due to an optimal stratification of patients and a rational use of different antileukemic agents among which L-asparaginase (L-ASNase) plays a fundamental role. This drug has been used in pediatric ALL chemotherapy protocols for almost 3 decades. In the 1970s and 1980s a chemically modified form of this enzyme called pegasparaginase (PEG-ASNase) was rationally synthesized to decrease immunogenicity of the enzyme and prolong its half-life. The different advantages of PEG-ASNase have been demonstrated in many clinical studies, the last of which underline the utility of this drug in front-line therapy of ALL. In this review, we discuss the pharmacological advantages and clinical potential of PEG-ASNase and its important use in first-line treatment of ALL.Keywords: pegasparaginase, acute, lymphoblastic leukemia, pegylation
The performance of air-turbine handpieces in general dental practice. (2005)

Variation in free-running speed, bearing resistance, illuminance and sound pressure level can be used effectively to monitor changes in air-turbine handpieces due to normal use. Although an increase in bearing resistance is associated with decreasing free-running speed, noise appears to be a useful indicator of imminent bearing failure. Assiduous adherence to manufacturers' directions for cleaning and lubrication may have contributed to increased bearing life.
A parallel WLS state estimator on shared memory computers (2007)

This paper describes our experience with developing a parallel weighted- least-square (WLS) state estimation (SE) program for shared-memory parallel computers. Since the key computational kernel of the WLS algorithm based on the Newton-Raphson approach is a solver of sparse linear equations, a significant part of our effort was focused on selecting, implementing and evaluating this algorithm. An optimized shared memory version of the conjugate gradient (CG) algorithm was found to be competitive to state-of-the-art implementation of LU solvers for the SE problem on the SGI Altix, a shared memory architecture. We also ported the full SE algorithm including CG to the Cray MTA-2 shared memory multithreaded architecture and investigated its performance.
Traveling-wave parametric generation of widely tunable, highly coherent femtosecond light pulses (1993)

We report on the generation of ultrashort tunable pulses with a cavityless traveling-wave scheme consisting of a parametric superfluorescence seed source and a parametric amplifier. We show that the traveling-wave approach, with its advantages of simplicity and direct generation of tunable energetic single pulses, can be used in the femtosecond regime, and to this end we discuss the performances that were obtained with pump pulses of ≈1-ps and 200-fs duration at wavelengths of 0.53 and 0.6 μm, respectively. Of particular interest is the β-barium borate-based traveling-wave parametric generator (type-II phase matching), since it offers the possibility of generating nearly transform-limited pulses that are continuously tunable within a wide spectral range to as high as 3 μm in the IR. With a diffraction-limited pump at 0.53 μm. we obtained tunable pulses in a 1.2× diffraction-limited beam, which could be focused, with an f/20 optics lens, to an intensity of 1013 GW/cm2. A temperature-tuned lithium triborate-based femtosecond parametric generator, with its smaller group-velocity dispersion and absence of walk-off, can operate at a pump energy of as low as 30 μJ in a 200-fs pulse.
Breakage and coalescence models for drops in turbulent dispersions (1994)

Abstract A substantial effort has been made by numerous investigators to describe droplet breakage and coalescence in turbulent dispersions. An attempt is made here to improve these models based on existing frameworks and recent advances described in the literature. Two‐step mechanisms are considered for both the breakage and coalescence models. The drop breakage function is structured as the product of the drop‐eddy collision frequency and breakage efficiency which reflect the energetics of turbulent liquid‐liquid dispersions. The coalescence function retains the former structure of the product of drop‐drop collision frequency and coalescence efficiency. The coalescence efficiency model has been modified to account for the effects of film drainage for drops with partially mobile interfaces. These models overcome several inconsistencies observed in previous efforts and are applicable for dense dispersions (about ϕ[0.10–0.30]). For the daughter drops produced by breakage, a probability density is proposed based on the energy requirements for the formation of daughter drops.
Identifying faults and gas chimneys using multiattributes and neural networks (2001)

Modern visualization and image processing techniques are revolutionizing the art of seismic interpretation. Emerging technologies allow us to interpret more data with higher accuracy in less time. The trend is shifting from horizon-based toward volume-based. New insights are gained by studying objects of various geologic origins and their spatial interrelationships. The standard way of highlighting objects is through seismic attribute analysis. Various attributes are tested in a trial-and-error mode, and one is selected as the optimal representation of the desired object. The selected attribute, which may be a mathematical composite of several attributes, is not sensitive to a particular geologic object but highlights any seismic position with similar attribute response.
Performance Analysis of Offloading Application-Layer Tasks to Network Processors (2023)

Offloading tasks to a network processor is one of the important ways to increase server performance. Hardware offloading of Transmission Control Protocol/Internet Protocol (TCP/IP) intensive tasks is known to significantly improve performance. When the entire application is considered for offloading, the impact on the server can be significant because it significantly reduces the load on the server. The goal of this thesis is to consider such a system with application-level offloading, rather than hardware offloading, and gauge its performance benefits.\nI am implementing this project on an Apache httpd server (running RedHat Linux), on a system that utilizes a co-located network processor system (IXP2855). The performance of the two implementations is measured using the SPECweb2005 benchmark, which is the accepted industry standard for evaluating Web server performance.