gebhart/patrepeval huggingface dataset:
A New Refracture-Candidate Diagnostic Test Determines Reservoir Properties and Identifies Existing Conductive or Damaged Fractures (2005)

Abstract A new refracture-candidate diagnostic test is presented that requires a brief injection at a pressure exceeding the fracture initiation and propagation pressure followed by an extended shut-in period with the pressure falloff recorded. Provided the time of injection is short relative to the reservoir response, the pressure falloff can be analyzed as a slug test by transforming and plotting the falloff data on a variable-storage, constant-rate drawdown type curve for a well producing from single or multiple finite- or infinite-conductivity vertical fractures in an infinite-acting reservoir. Characteristic variable storage behavior is used to diagnose a pre-existing fracture retaining residual width and to determine if a pre-existing fracture is damaged. Using the proposed model and analysis methodology, a quantitative type-curve/model match can be used to estimate reservoir properties. In addidtion to the new fracture diagnostic solution, a new single-phase fracture-injection/falloff dimensionless pressure solution is also provided along with new pressure-transient solutions for a well producing from multiple arbitrarily-oriented finite- or infinite-conductivity fractures.
Comprehensive mass spectrometry based biomarker discovery and validation platform as applied to diabetic kidney disease (2017)

A protein biomarker discovery workflow was applied to plasma samples from patients at different stages of diabetic kidney disease. The proteomics platform produced a panel of significant plasma biomarkers that were statistically scrutinised against the current gold standard tests on an analysis of 572 patients. Five proteins were significantly associated with diabetic kidney disease defined by albuminuria, renal impairment (eGFR) and chronic kidney disease staging (CKD Stage ≥1, ROC curve of 0.77). The results prove the suitability and efficacy of the process used, and introduce a biomarker panel with the potential to improve diagnosis of diabetic kidney disease.
Integrated frequency comb source of heralded single photons (2014)

We report an integrated photon pair source based on a CMOS-compatible microring resonator that generates multiple, simultaneous, and independent photon pairs at different wavelengths in a frequency comb compatible with fiber communication wavelength division multiplexing channels (200 GHz channel separation) and with a linewidth that is compatible with quantum memories (110 MHz). It operates in a self-locked pump configuration, avoiding the need for active stabilization, making it extremely robust even at very low power levels.
Optimization and Evaluation of a Sheathless Capillary Electrophoresis–Electrospray Ionization Mass Spectrometry Platform for Peptide Analysis: Comparison to Liquid Chromatography–Electrospray Ionization Mass Spectrometry (2011)

In this study we have evaluated the suitability of a sheathless capillary electrophoresis-electrospray ionization mass spectrometry (CE-ESI-MS) interface with a porous tip as the nanospray emitter for use in peptide analysis. A positively charged capillary coating and 0.1% formic acid as background electrolyte were used for separation upstream from mass spectrometry characterization. The influence of the distance between emitter tip and MS inlet, ESI voltage applied, and of the electroosmotic flow (EOF) on electrospray performance and efficiency of the system was investigated in detail. Under optimized conditions, less than 30 amol of a model peptide (angiotensin I) was required for a detection in the base peak electropherogram and positive identification via tandem MS. Three different cationic capillary coatings were investigated for stability, resolution, and EOF and were found to enable reproducible separations by CE-ESI-MS. After optimizing MS settings, the effectiveness of the CE-ESI-MS method developed was compared with a state-of-the-art nano-liquid chromatography (LC)-ESI-MS method by analyzing Arg-C-digested rat testis linker histones with both systems. With comparable amounts of sample applied, the number of identified peptides increased by more than 60% when using CE-ESI-MS. We found that low molecular mass peptides (below 1400 Da) were preferentially identified by CE-ESI-MS, since this group of peptides poorly interacted with the reversed-phase material in the nano-LC system. Finally, total analysis time in LC-ESI-MS for three runs including equilibration was nearly 4 times longer than that of CE-ESI-MS: 246 versus 66 min.
Systematic Design Exploration of Delta-Sigma ADCs (2004)

An algorithm for architecture-level exploration of the /spl Delta//spl Sigma/ A/D converter (ADC) design space is presented. Starting from the desired specification, the algorithm finds an optimal solution by exhaustively exploring both single-loop and cascaded architectures, with a single-bit or multibit quantizer, for a range of oversampling ratios. A fast filter-level step evaluates the performance of all loop-filter topologies and passes the accepted solutions to the architecture-level optimization step which maps the filters on feasible architectures and evaluates their performance. The power consumption of each accepted architecture is estimated and the best top-ten solutions in terms of the ratio of peak signal-to-noise+distortion ratio versus power consumption are further optimized for yield. Experimental results for two different design targets are presented. They show that previously published solutions are among the best architectures for a given target but that better solutions can be designed as well.
Disease‐modifying effects of ganglioside GM1 in Huntington's disease models (2017)

Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and psychiatric problems. Previous studies indicated that levels of brain gangliosides are lower than normal in HD models and that administration of exogenous ganglioside GM1 corrects motor dysfunction in the YAC128 mouse model of HD In this study, we provide evidence that intraventricular administration of GM1 has profound disease-modifying effects across HD mouse models with different genetic background. GM1 administration results in decreased levels of mutant huntingtin, the protein that causes HD, and in a wide array of beneficial effects that include changes in levels of DARPP32, ferritin, Iba1 and GFAP, modulation of dopamine and serotonin metabolism, and restoration of normal levels of glutamate, GABA, L-Ser and D-Ser. Treatment with GM1 slows down neurodegeneration, white matter atrophy and body weight loss in R6/2 mice. Motor functions are significantly improved in R6/2 mice and restored to normal in Q140 mice, including gait abnormalities that are often resistant to treatments. Psychiatric-like and cognitive dysfunctions are also ameliorated by GM1 administration in Q140 and YAC128 mice. The widespread benefits of GM1 administration, at molecular, cellular and behavioural levels, indicate that this ganglioside has strong therapeutic and disease-modifying potential in HD.
The Novel Gene <i>HOMOLOGOUS PAIRING ABERRATION IN RICE MEIOSIS1</i> of Rice Encodes a Putative Coiled-Coil Protein Required for Homologous Chromosome Pairing in Meiosis (2004)

We have identified and characterized a novel gene, PAIR1 (HOMOLOGOUS PAIRING ABERRATION IN RICE MEIOSIS1), required for homologous chromosome pairing and cytokinesis in male and female meiocytes of rice (Oryza sativa). The pair1 mutation, tagged by the endogenous retrotransposon Tos17, exhibited meiosis-specific defects and resulted in complete sterility in male and female gametes. The PAIR1 gene encodes a 492-amino acid protein, which contains putative coiled-coil motifs in the middle, two basic regions at both termini, and a potential nuclear localization signal at the C terminus. Expression of the PAIR1 gene was detected in the early stages of flower development, in which the majority of the sporocytes had not entered meiosis. During prophase I of the pair1 meiocyte, all the chromosomes became entangled to form a compact sphere adhered to a nucleolus, and homologous pairing failed. At anaphase I and telophase I, chromosome nondisjunction and degenerated spindle formation resulted in multiple uneven spore production. However, chromosomal fragmentation frequent in plant meiotic mutants was never observed in all of the pair1 meiocytes. These observations clarify that the PAIR1 protein plays an essential role in establishment of homologous chromosome pairing in rice meiosis.
Vibration Response of 3-D Space Accessible Sandwich Composite (2008)

A 3-D sandwich composite comprising of E-glass core piles which are woven to the facesheets is considered in this work. This arrangement creates interstitial spaces in the core which can be used for foam infusion for sound/vibration damping, fluid storage, or for routing wires or inserts, in addition to providing strength. The vibroacoustic response of such multi-functional materials has received little attention and is an important issue when the structure witnesses mechanical vibrations. This article presents the vibration related studies carried out on the 3-D sandwich composite, infused with SC-15 resin. The frequency response function (FRF) and the damping ratios are the parameters of interest for this study. In this study the experimental data is presented for the unfoamed (as received) core configuration and the core filled with the polyurethane (PUR) foam. The average damping ratio of the unfoamed sandwich panel was found to be 0.55%. An increase of 150% in the damping ratio was observed for the PUR foam filled panels for a 77% increase in weight when compared to an unfoamed sandwich panel. Use of vibration as a non-destructive damage detection technique is demonstrated for beam specimens damaged by flexural loading. A reduction of 35% in the resonant frequency and 193% increase in the damping ratio was observed for approximately 6% core damage of the sandwich composite.
A Theory of Traffic Regulators for Deterministic Networks With Application to Interleaved Regulators (2018)

We introduce Pi-regulation, a new definition of traffic regulation which extends both the arrival curves of network calculus and Chang's max-plus g-regulation, and also includes new types of regulation, such as packet rate limitations. We provide a new exact equivalence between min-plus and max-plus formulations of traffic regulation. We show the existence and a max-plus representation of per-flow minimal regulators, which extends the concepts of packetized greedy shapers and minimal g-regulators. We show that any minimal regulator, placed after any arbitrary system that is FIFO for the flow of interest, does not increase the worst-case delay of the flow. We extend the theory to interleaved regulation and introduce the concept of minimal interleaved regulator. It generalizes the urgency-based shaper that was recently proposed by Specht and Samii as a simpler alternative to per-flow regulators in deterministic networks with aggregate scheduling. With this regulator, packets of multiple flows are processed in one FIFO queue and only the packet at the head of the queue is examined against the regulation constraints of its flow. We show that any minimal interleaved regulator, placed after any arbitrary FIFO system does not increase the worst-case delay of the combination.
e-러닝 환경에서 정보제시 시 색상과 명도차이가 회상과 재인에 미치는 영향 (2008)

본 연구는 e-러닝 환경에서 학습 내용에 제시되는 색채가 인간의 인지과정에 어떠한 영향을 미치는가를 알아보고자 하였다. 이를 위해 고등학교 2학년의 동일계열 165명을 연구대상으로 선정하여, 실험 1은 1개 집단에 한 화면에 빨강, 녹색, 파랑의 세 가지 색상의 단어가 있는 학습콘텐츠를 제시하여 색상이 미치는 회상과 재인의 정도를 t-test를 통해 측정하였으며, 실험 2는 유사색 배색집단과 보색 배색 집단으로 나누어 각 집단에 명도차이가 큰 배색의 단어, 명도 차이가 작은 배색의 단어를 제시하여 배색에서 색상의 차이와 명도의 차이가 주는 회상과 재인의 정도를 ANOVA를 통해 측정하였다. 이를 위한 검사도구로는 색상의 제시 방법에 따라 실험자의 재인과 회상정도를 측정하는 e-러닝 콘텐츠를 제작하여 활용하였다. 연구의 결과는 다음과 같다. 첫째, e-러닝의 학습 내용에서 파장에 의한 색상의 차이에 의해 제시된 학습내용은 회상과 재인의 기억인출에는 유의미한 차이가 없는 것으로 분석되었다. 즉 단독으로 사용되어진 색상 자체로는 기억에 미치는 유의미한 효과는 없는 것이다. 둘째, 배색에 의한 색상 차이에 의해 제시된 학습내용에서는 색상 차이가 큰 배색이 회상과 재인에 유의한 것으로 나타났다. 셋째, 배색에 의한 명도 차이에 의해 제시된 학습내용에서는 명도 차이가 큰 배색이 재인에 유의미한 영향을 미치는 것으로 나타났다. 넷째, 색상과 명도 차이의 상호작용이 회상과 재인에 미치는 효과에서는 색상과 명도의 차이가 모두 큰 배색이 기억에 보다 유의한 것으로 나타났다. 즉 사용하는 색채의 색상과 명도 차이 모두가 큰 배색을 사용하는 것이 기억에 가장 도움이 되고, 색상이나 명도 한 가지 만을 고려하였을 때보다는 상호작용하였을 때 그 효과가 보다 긍정적이라는 것을 알 수 있다.
A lightweight encryption method suitable for copyright protection (1998)

In this paper we propose a new lightweight encryption algorithm called MX. This algorithm has high performance and sufficient robustness, so that it is suitable for copyright protection systems in both CE and IT devices.
Synthesis and characterization of cyclic liquid crystalline oligomers based on 1-(4-hydroxy-4'-biphenylyl)-2-(4-hydroxyphenyl)butane and 1,10-dibromodecane (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of cyclic liquid crystalline oligomers based on 1-(4-hydroxy-4'-biphenylyl)-2-(4-hydroxyphenyl)butane and 1,10-dibromodecaneV. Percec, M. Kawasumi, P. L. Rinaldi, and V. E. LitmanCite this: Macromolecules 1992, 25, 15, 3851–3861Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ma00041a005https://doi.org/10.1021/ma00041a005research-articleACS PublicationsRequest reuse permissionsArticle Views194Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation by multivariate analysis of off-flavor in headspace volatiles formed during storage of beer. (1991)

When beers were stored for 0, 1, 2, 3, and 4 weeks at 37°C, a cardboard flavor was generated with the increase in storage terms. Seventy-two peaks detected by GC analysis of headspace gas on beer were used as variables for the multivariate analysis. Nine compounds including furfural and acetoin, which had rotated factor loadings of more than 0.5 on second factor axis, were extracted as components highly correlated with the formation of the cardboard flavor. Furfural and three compounds were extracted as important indices for discrimination of beer with storage terms by stepwise discriminant analysis.
Enabling large-scale genome editing at repetitive elements by reducing DNA nicking (2020)

To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell by overcoming the cell death associated with DNA double-strand breaks and single-strand breaks. We used a set of gRNAs targeting repetitive elements-ranging in target copy number from about 32 to 161 000 per cell. dBEs enabled survival after large-scale base editing, allowing targeted mutations at up to ∼13 200 and ∼12 200 loci in 293T and human induced pluripotent stem cells (hiPSCs), respectively, three orders of magnitude greater than previously recorded. These dBEs can overcome current on-target mutation and toxicity barriers that prevent cell survival after large-scale genome engineering.
A fuzzy description of the Henon chaotic map (2005)

In this paper it is described how chaotic dynamics could be generated by means of fuzzy systems. The approach is based on a linguistic description of chaotic phenomena, that can be easily related to a fuzzy system design. It allows building chaotic generators, (useful in several industrial application in which randomness is needed) by means of few fuzzy sets and using a small number of fuzzy rules. Fuzzy descriptions of the well-known two dimensional discrete chaotic map is therefore introduced, denoting a good degree of approximation together with an easy design of the system obtained in a very intuitive way.
Antimicrobial activity of carbene complexes of rhodium(I) and ruthenium(II). (1996)

Twenty-four carbene-rhodium(I), carbene-ruthenium(II) complexes and related compounds were evaluated for their in vitro antimicrobial activity against the Gram-positive bacteria Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 29213) and Gram-negative bacteria Escherichia coli (ATCC 25922), Pseudmonas aeruginosa (ATCC 27853). The compounds 1, 2, 3, 5, 7, 8, 9, 16, 18 and 19 were found very effective to inhibit the growth of Enterococcus faecalis and Staphylococcus aureus at the minimum inhibitory concentrations (MICs) of 5, 25, 5, 50, 25, 24, 24, 24, 6.25and 12.5 micrograms/ml, respectively. The compounds 6, 10, 12, 14, 15 and 17 were significantly effective against Enterococcus faecalis and Staphylococcus aureus with MIC values of 100-200 micrograms/ml. The compounds 2, 6 and 11 were also significantly effective against Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa with MIC values of 200-400 micrograms/ml.
FDHelper: Assist Unsupervised Fraud Detection Experts with Interactive Feature Selection and Evaluation (2020)

Online fraud is the well-known dark side of the modern Internet. Unsupervised fraud detection algorithms are widely used to address this problem. However, selecting features, adjusting hyperparameters, evaluating the algorithms, and eliminating false positives all require human expert involvement. In this work, we design and implement an end-to-end interactive visualization system, FDHelper, based on the deep understanding of the mechanism of the black market and fraud detection algorithms. We identify a workflow based on experience from both fraud detection algorithm experts and domain experts. Using a multi-granularity three-layer visualization map embedding an entropy-based distance metric ColDis, analysts can interactively select different feature sets, refine fraud detection algorithms, tune parameters and evaluate the detection result in near real-time. We demonstrate the effectiveness and significance of FDHelper through two case studies with state-of-the-art fraud detection algorithms, interviews with domain experts and algorithm experts, and a user study with eight first-time end users.
Determination of Lifting Abilities: A Comparative Study of Four Techniques (1987)

The main objective of this study was to test the differences among four techniques for the determination of lifting abilities. This study introduced a new submaximal isometric strength testing technique. The proposed test was based on the concept of acceptable maximum effort (AME) which is the level of static exertion the individual is willing to perform voluntarily and comfortably without over-exertion (as opposed to the maximum ability of performance). Twelve male and five female subjects underwent the protocol of the four strength testing techniques investigated: isometric maximum voluntary contraction (MVC); maximum acceptable weight (MAW); maximum dynamic lifting (MDL); and acceptable maximum effort (AME). The results showed that MAW recorded the lowest values followed by AME, then MDL, then MVC. The correlation between AME and MAW was higher than that found between MVC and MAW. Also, it was found that AME is a reproducible measure of muscular functional abilities. On the average, the coefficient of variation was less than 15% for data for both males and females. The implications of these results in determining lifting abilities are discussed.
Transport performance evaluation of an ATM-based UMTS access network (2002)

One of the challenges of the Universal Mobile Telecommunication System (UMTS) is to bring closer together the mobile and the broadband fixed networks (B-ISDN/ATM). The objective is to use the same fixed network infrastructure and to offer mobile terminal users the same services as those available to the fixed terminal users. In this context, the design of the UMTS pursues service, transport and signaling protocol integration with fixed B-ISDN. This paper focuses on the transport integration aspects. Guidelines and mechanisms towards the definition of a fixed, ATM-based, access transport system for the target UMTS are given. The evaluation of the transport architecture, considering the European Advanced TDMA (ATDMA) technology at the radio interface, demonstrates the behavior of the system under various speech traffic loads, and yields results which fall within acceptable ATM performance measures.
VEGF nuclear accumulation correlates with phenotypical changes in endothelial cells (2000)

Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a prominent role in normal vascular biology and pathology. In an experimental wound model, the mechanical disruption of monolayers of cultured endothelial cells resulted in two phenotypically distinct cell subpopulations in which VEGF was internalized by alternative endocytotic pathways and delivered to different subcellular compartments. In the cells away from the wound, VEGF was internalized via the classical receptor-mediated endocytosis pathway and accumulated in the endosomal compartment, whereas in the cells situated at the edges of a wound, VEGF was rapidly taken up and translocated to the nucleus. VEGF internalization and subsequent nuclear accumulation only occurred for a short period of time after the wounding and was specifically abolished by antibodies that bind to the KDR binding site of VEGF. In the cells with VEGF nuclear accumulation, the levels of wound healing related proteins, such as Factor VIII (FVIII), tissue factor (TF) and tissue plasminogen activator, rapidly and dramatically increased compared to the cells that internalized VEGF via the classical endocytotic pathway. The increase in FVIII and TF was abolished when the nuclear transport is blocked. These data suggest that nuclear VEGF accumulation may be involved in modulating the levels of the proteins of the coagulation and fibrinolysis pathways.
Amiodarone prophylaxis for atrial fibrillation of high-risk patients after coronary bypass grafting: a prospective, double-blinded, placebo-controlled, randomized study (2006)

The incidence of post-operative AF among high-risk patients was significantly reduced by a prophylactic amiodarone treatment resulting in a shorter time of intensive care unit and hospital stay. Our data supports the prophylactic use of amiodarone in peri-operative period in patients at high risk for AF after CABG.
Fanout-tree restructuring algorithm for post-placement timing optimization (1995)

This paper proposes a fanout-tree restructuring algorithm for post-placement timing optimization to meet timing constraints. The proposed algorithm restructures a fanout-tree by finding a tree in a graph which represents a multi-terminal net, and inserts buffer cells and resizes cells based on an accurate interconnection RC delay without degrading routability. The algorithm has been implemented and applied to a number of layout data generated by timing driven placement. Application results show a 17% reduction in circuit delay on the average.