gebhart/patrepeval huggingface dataset:
A 14.5mm<sup>2</sup> 8nW −59.7dBm-sensitivity ultrasonic wake-up receiver for power-, area-, and interference-constrained applications (2018)

The next generation of the Internet of Things is envisioned to include unobtrusive, distributed mm-sized nodes capable of sensing and communicating information about their surroundings. Wake-up receivers (WuRXs) - ultra-low-power receivers that monitor their environment for a wake-up signature - are an important part of this vision, as they can extend the lifetime of a wireless node by keeping it asleep until interrogated. The state of the art in WuRXs, measured in terms of sensitivity and power, has recently been advanced by streamlining the signal path to include fewer power-hungry gain stages and instead obtaining the gain at the chip-antenna interface [1,2]. This has led to excellent power-sensitivity performance, but the accompanying increase in size hampers the applicability of these techniques in size-conscious applications, such as surveillance, asset tracking, and ubiquitous sensing. Moreover, size-reduction methods based on RF antenna miniaturization are fundamentally limited by high antenna Qs at low size-to-wavelength ratios [3]; efficiently matching to these antennas requires, in turn, high-Q passives that are generally unavailable at mm-scale.
Experimental Investigations on Rotary Vane Compressors (1980)

A loss analysis of a rotary vane compressor is taken by measurements and shows the influences of mechanical friction, oil injection and non-adapted pressure ratio.
Phase Transition of a Polymer Gel in Pure and Mixed Solvent Media (1987)

A volume phase transition of poly-N-isopropylacrylamide (NIPA) gel immersed in some pure and mixed solvents has been investigated experimentally. A slightly discontinuous transition of NIPA get in water changed to a more distinctly first-order transition on adding a small amount (<20%) of alcohols to water. As the concentration of alcohols in the mixed solvent increased further, the volume transition blurred and eventually disappeared. Analyzing the experimental results on the basis of the mean field theory of polymer solution, it has been shown that the polymer-solvent interaction parameter χ exhibits a drastic change at the volume transitions. This indicates that the enthalpy and entropy of solution depend strongly on polymer concentration.
Senescence responsive transcriptional element (2023)

Recombinant polynucleotides have expression control sequences that have a senescence responsive element and a minimal promoter, and which are operatively linked to a heterologous nucleotide sequence. The molecules are useful for achieving high levels of expression of genes in senescent cells. Methods of inhibiting expression of genes in senescent cells also are provided.
Fabrication and Characterization of Epitaxial Films of Superconductor NbN and Highly Spin-Polarized Heusler Alloy Co2Fe0.4Mn0.6Si (2017)

We report structural, magnetic, and transport properties of epitaxial films of superconductor NbN and highly spin-polarized Heusler alloy Co <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Fe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.4</sub> Mn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.6</sub> Si (CFMS). The saturation magnetization Ms of the film was 870 emu/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , which is slightly smaller than values reported earlier. With an increase of CFMS thickness dCFMS, the sheet resistance R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sq</sub> decreased and the upper critical field μ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c2</sub> (0) decreased monotonically, while the superconducting transition temperature T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> exhibited a minimum around dCFMS = 3 nm. A theoretical analysis of superconducting fluctuations revealed that the high spin polarization of the CFMS layer affected the pair breaking parameter δ, the superconducting coherence length ξ(0), and the diffusion coefficient D.
Process for the detection of micro-cracks (2023)

A process for the nondestructive testing of ceramic objects to detect the presence of defects and micro-cracks in the surface in which a solution of silver nitrate is applied to the surface of the object which penetrates into the surface defects, drying the object so that the silver nitrate remains in the defects, and preparing an X-ray radiograph whereby any defects and micro-cracks will appear in the radiograph.
Covalently Crosslinked and Physically Stable Polymer Coatings with Chemically Labile and Dynamic Surface Features Fabricated by Treatment of Azlactone-Containing Multilayers with Alcohol-, Thiol-, and Hydrazine-Based Nucleophiles (2016)

We report approaches to the design of covalently crosslinked and physically stable surface coatings with chemically labile and dynamic surface features based on the functionalization of azlactone-containing materials with alcohol-, thiol-, and hydrazine-based nucleophiles. Past studies demonstrate that residual azlactone groups in polymer multilayers fabricated by the reactive layer-by-layer assembly of poly(2-vinyl-4,4-dimethylazlactone) and branched poly(ethylenimine) can react with amine-based nucleophiles to impart new surface and bulk properties through the creation of chemically stable amide/amide-type bonds. Here, we demonstrate that the azlactone groups in these covalently crosslinked materials can also be functionalized using less nucleophilic alcohol- or thiol-containing compounds, using an organic catalyst, or converted to reactive acylhydrazine groups by direct treatment with hydrazine. These methods (i) broaden the pool of molecules that can be used for post-fabrication functionalization to include compounds containing alcohol, thiol, or aldehyde groups and (ii) yield surface coatings with chemically labile amide/ester-, amide/thioester-, and amide/imine-type bonds that make possible the design of new dynamic and stimulus-responsive materials (e.g., surfaces that release covalently bound molecules or undergo changes in extreme wetting behaviors in response to specific chemical stimuli). Our results expand the range of functionality that can be installed in, and thus the range of new functions that can be imparted to, azlactone-containing coatings beyond those that can be accessed using primary amine-based nucleophiles. The chemical approaches demonstrated here using model polymer-based reactive multilayer coatings are general and should thus also prove useful for the design of new responsive surfaces based on other types of azlactone-functionalized materials.
Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa (2014)

Revertant mosaicism is a naturally occurring phenomenon involving spontaneous correction of a pathogenic gene mutation in a somatic cell. It has been observed in several genetic diseases, including epidermolysis bullosa (EB), a group of inherited skin disorders characterized by blistering and scarring. Induced pluripotent stem cells (iPSCs), generated from fibroblasts or keratinocytes, have been proposed as a treatment for EB. However, this requires genome editing to correct the mutations, and, in gene therapy, efficiency of targeted gene correction and deleterious genomic modifications are still limitations of translation. We demonstrate the generation of iPSCs from revertant keratinocytes of a junctional EB patient with compound heterozygous COL17A1 mutations. These revertant iPSCs were then differentiated into naturally genetically corrected keratinocytes that expressed type XVII collagen (Col17). Gene expression profiling showed a strong correlation between gene expression in revertant iPSC-derived keratinocytes and the original revertant keratinocytes, indicating the successful differentiation of iPSCs into the keratinocyte lineage. Revertant-iPSC keratinocytes were then used to create in vitro three-dimensional skin equivalents and reconstitute human skin in vivo in mice, both of which expressed Col17 in the basal layer. Therefore, revertant keratinocytes may be a viable source of spontaneously gene-corrected cells for developing iPSC-based therapeutic approaches in EB.
Pattern-based fault diagnosis using neural networks (1988)

The detection and diagnosis of faults in real time are active areas of research in knowledge-based expert systems. Several methods of diagnosis have been applied to a variety of physical systems. Rule-based approaches have been applied successfully to some domains. However, encoding knowledge in rule bases raises many difficult knowledge acquisition issues; in addition, rule-based systems are often too slow to be effectively applied in a real-time environment. More advanced diagnostic systems may incorporate a simulation of the physical system in the knowledge base. Although simulation-based expert systems can exhibit powerful capabilities, simulating the domain properly may be difficult and too computationally intensive for real-time diagnosis.
Freeze‐Drying, Pharmaceuticals (2010)

Abstract This article provides an overview of the fundamental aspects for pharmaceutical freeze‐drying, including the rationale for freeze‐drying process design and control, the basics of formulation development for freeze‐drying, the importance of the container‐closure system, and a general description of pharmaceutical freeze‐dryers. In the second part of this article, the challenges in freeze‐drying scale‐up and transfer, freezing control, use of cosolvent, freeze‐drying in syringes, process analytical technology, and quality‐by‐design in freeze‐drying have been discussed, and some new advancements related to these aspects are also highlighted.
Millimeter-Wave Circuits for 60GHz and Beyond (2010)

Research in the mm-wave band using CMOS and SiGe technologies has gained momentum over the past few years. Millimeter-wave circuits are expected to enter consumer electronics in the near future. 60GHz circuits have the potential to be used in high definition wireless video transmission and high data-rate point-to-point communication. 77GHz has been explored for automotive radar and is expected to become more ubiquitous in coming years. 90GHz has been investigated for imaging and remote sensing applications.Raw silicon transistor performance has improved dramatically in the past decade, which has spurred much of the research. The potential low cost of silicon ICs, especially CMOS, is great motivation to design mm-wave circuits for volume production.This dissertation is divided into two parts. In the first part, the design of a60GHz CMOS receiver is presented. Design methodologies for robust operation at 60GHz are introduced at device and circuit levels. Key building blocks of a 60GHz receiver are investigated and several design techniques are proposed to increase the performance of the 60GHz circuits. Second part explores the potential of mm-wave design for imaging applications. Performance requirements and challenges of a 90GHz power amplifier for imaging applications are explored. Circuit and system level design details of a pulsed power amplifier are provided and methodologies for enhancing the performance of those designs are introduced. In the end, A prototype of this power amplifier and its integrated version in an ultra wideband pulsed transmitter are presented.This thesis is expected to provide a design framework for achieving predictable and desired performance at mm-wave band.
The Frequent Image Frames Enhanced Digital Orthorectified Mapping (FIFEDOM) Camera for Acquiring Multiangular Reflectance From the Land Surface (2007)

The Frequent Image Frames Enhanced Digital Orthorectified Mapping (FIFEDOM) camera was designed to provide a cost-effective remote-sensing method for accurate acquisition of forest information, such as spatial distributions of individual tree species and tree structures for forest monitoring and management. Compared with existing regular digital cameras, the FIFEDOM camera has several unique features as follows: (1) it can collect data not only in the visible bands (550 and 670 nm) but also in the near-infrared band (800 nm); (2) it has a frame rate of up to 3 frames/s with a frame size of 3500 times 2300; and (3) it has a wide angular field view with 150deg along track and 78.8deg across track. Its high frame rate and wide angular field view allow it to obtain a sequence of images that oversample ground target areas. The multiangle database and bidirectional reflectance signatures of forest canopies can be generated from the oversampled image data, which can be used to identify forest species and estimate tree structures. In addition, the multiframe highly overlapped FIFEDOM data can also be used to generate a very dense, high-quality, and reliable digital surface model. Effective methods for radiometric and geometric calibration of the FIFEDOM camera were developed in this paper. A data-acquisition campaign was carried out in 2004 over the Algoma boreal forest, Ontario, Canada. The FIFEDOM data were validated using the data acquired by the Compact Airborne Spectrographic Imager instrument, which was flown together with the FIFEDOM camera.
SEROLOGICAL STABILITY IN SAMPLES OF Brucella abortus SUBJECTED TO FREEZE FOR USE AS A CONTROL IN THE POLARIZED FLUORESCENCE TEST (2023)

Brucellosis is one of the most important zoonoses with worldwide distribution, caused by bacteria belonging to the genus Brucella.In Mexico, bovine brucellosis is endemic and is caused by Brucella abortus.The objective was to compare the antibody titer in samples before and after freezing without the addition of preservatives and/or molecular stabilizers that could intervene in their biochemical behavior during the polarized fluorescence assay.200 healthy cows and 200 infected with Brucella race Friesian-Holsteins from 38 to 48 months of age, underwent the FPA test and the sera were kept frozen (-20C).Data analysis was performed through descriptive statistics using the IBM SPSS Statistics 25 Software.Statistical calculations were performed using the Wilcoxon test, comparison between the two means and the average reference values.In all cases, a significance level of 0.01 and a 99% confidence interval were considered.A P value < (0.01) was obtained in the Kolmogorov-Smirnov normality test.The behavior in the histogram was obtained a mean = 0.53 and standard deviation 3.123.Regarding the individual data of the serological samples of bovines with brucellosis, similar results were obtained before and after freezing.The Wilcoxon signed rank test indicated that 84 samples (42%) decreased their mP values after freezing, while in the remaining 116 samples (58%) this value increased.There was no significant difference.In the serum samples, serological stability was observed for six months analyzed in FPA.
Blind image quality assessment based on fractal description of natural scenes (2015)

Motivated by the observation that visual perception is quite sensitive to the irregularities of natural scenes, the incorporation of the multi‐fractal spectrum and the fractal dimension into blind image quality assessment for perceptual features extraction is introduced. On the basis of a box‐counting method, the multi‐fractal spectrum and fractal dimension are extracted from natural scenes and then their discrepancies are quantified. Experiments on the LIVE image database show that consistency with subjective evaluation is achieved. In addition, these are remarkable advantages when compared with other popular methods are demonstrated.
A multi-animal tracker for studying complex behaviors (2017)

Together, our tracker provides a powerful and simple system to study complex behaviors in a quantitative, high-throughput, and accurate manner.
SMT Solvers: Theory and Practice (2008)

DPLL We now return to DPLL. To facilitate a deeper look at DPLL, we use a high-level framework called Abstract DPLL [NOT06]. Summer School on Verification Technology, Systems & Applications, September 17, 2008 – p. 53/98
DNA-programmed assembly of nanostructures (2005)

DNA is a unique material for nanotechnology since it is possible to use base sequences to encode instructions for assembly in a predetermined fashion at the nanometre scale. Synthetic oligonucleotides are readily obtained by automated synthesis and numerous techniques have been developed for conjugating DNA with other materials. The exact spatial positioning of materials is crucial for the future development of complex nanodevices and the emerging field of DNA-nanotechnology is now exploring DNA-programmed processes for the assembly of organic compounds, biomolecules, and inorganic materials.
Influence of endogenous cholinergic tone and α-adrenergic pathways on growth hormone responses to His-d-Trp-Ala-Trp-d-Phe-Lys-NH2 in the dog (1993)

His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6) is a synthetic peptide unrelated to any known hypothalamic-releasing hormone including growth hormone-releasing hormone (GHRH). Interestingly, this peptide induces a dose-related increase in plasma GH levels in all species tested so far. The aim of this study was to investigate the action of GHRP-6 alone or in combination with GHRH on GH release in dogs. In addition, the activation or blockade of endogenous cholinergic tone and alpha-1 adrenoceptors on GHRP-6-stimulated GH secretion was assessed. In adult Beagle dogs (n = 10), GHRP-6 (90 micrograms i.v.) increased basal GH levels from 2.6 +/- 1.5 to 14.4 +/- 3.1 micrograms/l (mean +/- S.E.M.) after 15 min. GHRH (50 micrograms i.v.) induced a GH peak of 9.7 +/- 2.2 micrograms/l at 15 min. The combined administration of GHRP-6 and GHRH strikingly potentiated canine GH release with a peak of 54 +/- 9.0 micrograms/l (P < 0.01). Pretreatment with the cholinergic agonist pyridostigmine (30 mg per os) increased GHRP-6-stimulated GH secretion (37.9 +/- 10.1 micrograms/l P < 0.05), while the muscarinic blocker atropine (100 micrograms i.v.) completely abolished (GH peak lower than 2 micrograms/l) the stimulatory action of GHRP-6. On the other hand, administration of the alpha-2 adrenergic agonist clonidine (4 micrograms/kg i.v.) increased basal plasma GH levels without affecting GH responses to GHRP-6.(ABSTRACT TRUNCATED AT 250 WORDS)
Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance (2015)

Recent major advances in understanding the molecular basis of acute myeloid leukemia (AML) provide a double-edged sword. Although defining the topology and key features of the molecular landscape are fundamental to development of novel treatment approaches and provide opportunities for greater individualization of therapy, confirmation of the genetic complexity presents a huge challenge to successful translation into routine clinical practice. It is now clear that many genes are recurrently mutated in AML; moreover, individual leukemias harbor multiple mutations and are potentially composed of subclones with differing mutational composition, rendering each patient's AML genetically unique. In order to make sense of the overwhelming mutational data and capitalize on this clinically, it is important to identify (1) critical AML-defining molecular abnormalities that distinguish biological disease entities; (2) mutations, typically arising in subclones, that may influence prognosis but are unlikely to be ideal therapeutic targets; (3) mutations associated with preleukemic clones; and (4) mutations that have been robustly shown to confer independent prognostic information or are therapeutically relevant. The reward of identifying AML-defining molecular lesions present in all leukemic populations (including subclones) has been exemplified by acute promyelocytic leukemia, where successful targeting of the underlying PML-RARα oncoprotein has eliminated the need for chemotherapy for disease cure. Despite the molecular heterogeneity and recognizing that treatment options for other forms of AML are limited, this review will consider the scope for using novel molecular information to improve diagnosis, identify subsets of patients eligible for targeted therapies, refine outcome prediction, and track treatment response.
Mutations in the Transmembrane Domain of APP Altering γ-Secretase Specificity (1997)

Alzheimer's disease (AD) beta-amyloid peptide (Abeta and betaA4) is derived from the amyloid precursor protein (APP) by the subsequent action of the so-far unidentified beta- and gamma-secretases. gamma-secretase, which generates the C-terminus of Abeta, cleaves within the transmembrane domain of APP, preferentially after Abeta-residue 40 (Abeta 40) but also after residue 42 (Abeta 42). This Abeta 42 represents the major subunit of the plaques in AD. Since the position of gamma-secretase cleavage is crucial for understanding the pathogenic pathway, we investigated the effect of different point mutations at Thr43 on gamma-secretase specificity in SPA4CT (SPC99)-expressing COS7 cells. These constructs only require gamma-cleavage for Abeta release. We observed that all Thr43 mutations altered the specificity of gamma-secretase. Small hydrophobic residues favored the generation of Abeta 42, leading to an increase in the 42/40 ratio of Abeta (1.6-2.8-fold). The increase was even stronger (5.6-5.8-fold) when combined with the familial mutation Val46Phe. Thus, these constructs might be highly valuable for the generation of animal models for AD. Processing of full-length APP or SPA4CT yielded the same 42/40 ratio of Abeta (4. 7%). Both constructs, bearing the familial AD mutation Val46Phe, led to a similar increase in the 42/40 ratio (3.3- versus 3.6-fold). The p3 fragment, produced by alpha- and gamma-secretase, showed 42/40 ratios similar to Abeta when derived from wild-type and mutant proteins. These results suggest that the different Abeta- and p3-species are generated by gamma-cleavage activities with a similar enzymatic mechanism.
Bayesian feature and model selection for Gaussian mixture models (2006)

We present a Bayesian method for mixture model training that simultaneously treats the feature selection and the model selection problem. The method is based on the integration of a mixture model formulation that takes into account the saliency of the features and a Bayesian approach to mixture learning that can be used to estimate the number of mixture components. The proposed learning algorithm follows the variational framework and can simultaneously optimize over the number of components, the saliency of the features, and the parameters of the mixture model. Experimental results using high-dimensional artificial and real data illustrate the effectiveness of the method.
Radiosynthesis of a chloroacetanilide herbicide ([<i>phenyl</i>‐4‐<sup>3</sup>H] acetochlor) and a dichloroacetamide safener for herbicides ([2, 2‐<i>dimethyl</i>‐<sup>3</sup>H]R‐29148) (1995)

Abstract 2‐Chloro‐ N ‐(ethoxymethyl)‐ N ‐(2‐ethyl‐6‐methylphenyl)acetamide (the chloroacetanilide herbicide acetochlor) and 3‐(dichloroacetyl)‐ 2,2,5‐trimethyl‐1,3‐oxazolidine (the dichloroacetamide safener R‐ 29148) are required at high specific activity for studies on their metabolism and mode of action. [ phenyl ‐4‐ 3 H]Acetochlor was obtained at 22 Ci/mmol in 71% yield by reductive dehalogenation of iodoacetochlor with tritium gas in ethanol in the presence of palladium on carbon and triethylamine. [2,2‐ dimethyl ‐ 3 H]R‐29148 was prepared at 15 Ci/mmol by treating acetone and 1‐amino‐2‐propanol in pentane with two equivalents of NaOH in tritiated water ( i.e . hydroxide ion‐catalyzed enolization of acetone) followed by dichloroacetyl chloride.