gebhart/patrepeval huggingface dataset:
Photoassisted decomposition of water at the gas-solid interface on titanium dioxide (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoassisted decomposition of water at the gas-solid interface on titanium dioxideH. Van Damme and W. Keith HallCite this: J. Am. Chem. Soc. 1979, 101, 15, 4373–4374Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ja00509a055https://doi.org/10.1021/ja00509a055research-articleACS PublicationsRequest reuse permissionsArticle Views339Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TRANSCLUDED DOCUMENTS: ADVANTAGES OF REUSING DOCUMENT FRAGMENTS (2002)

Quoting parts of a document is a very common task when writing scientific papers. Usually an author cut-and-pastes a source quote to a new document, which inherently causes problems. Transclusions – invented in 1960 by Ted Nelson – are a possible solution: they are a kind of function which returns the data to be included in a new document and also adds some links to and from the original context of the quote. This paper presents some ideas and problems when using transclusions in an existing digital journal environment. The creation process of transclusions with LATEX-macros is described and tools supporting this task are listed in this paper. After uploading a special ‘markuped’ document to the server, a serverprocess is responsible for assembling the content. This includes the transfer of up-to-date content to the client, management of changes etc. Additional navigation (i.e. hyperlinks) is also generated on the server side, therefore users are not forced to use a dedicated browser for the journal articles. Authors and readers of a document using transclusions profit from this architecture and the original context of a quote is just a mouse-click away. The paradigm of transclusions is useful for all participants involved in the creation and reading of articles.
Active Control of Rotor–Stator Interaction Noise Using Stator-Mounted Actuators (2014)

Active control of rotor–stator interaction noise is studied numerically using a locally oscillating stator surface. A stator of 24 blades inside an infinite coaxial duct is considered. The governing equations are linearized three-dimensional Euler equations and solved with an explicit numerical technique based on a high-order approximation of spatial derivatives. A number of parameters governing actuation-induced sound field and control performance are investigated. It is found that the actuation-induced sound field and noise reduction achieved depend on the actuation amplitude and frequency. The side and position, where actuation is imposed, of the blade as well as actuator geometry are also crucial for the control performance. The downstream-radiated sound power may be reduced by 50% or more over a range of frequencies given an optimum combination of control parameters.
Dynamic optical coherence tomography of skin physiology (2009)

OCT is highly potential for in vivo observation of dynamic physiological functions of small organs underneath the skin surface. Particularly, real-time OCT imaging of a small artery and the dynamics of mental sweating are demonstrated.
Pressure-Modulated Selective Electrokinetic Trapping for Direct Enrichment, Purification, and Detection of Nucleic Acids in Human Serum (2018)

Micro total-analysis systems (μTAS) have been extensively developed for the detection of nucleic acids (NAs) in resource-limited settings in recent years, yet the sample-preparation steps that interface real-world samples with on-chip analytics remain as the technical bottleneck. We report pressure-modulated selective electrokinetic trapping (PM-SET) for the direct enrichment, purification, and detection of NAs in human serum in one step without involving tedious solid-phase extraction, chemical amplification, and surface-hybridization-based assays. Under appropriately modulated hydrostatic pressures, NAs in human serum were selectively enriched in an electrokinetic concentrator with the majority of background proteins removed, achieving an enrichment factor of >4800 in 15 min. A sequence-specific NA was detected simultaneously during the enrichment process using a complementary morpholino (MO) probe, realizing a limit of detection of 3 pM in 15 min. PM-SET greatly reduces the cost, time, and complexity of sample preparation for NA detection and could be easily interfaced with existing NA-detection devices to achieve true sample-to-answer biomolecular analytics.
Combustion synthesis of the magnetoresistive double perovskite (Ba1.6Sr0.4)FeMoO6 (2003)

Structural, magnetic, and magnetoresistive properties of the double perovskite (Ba1.6Sr0.4)FeMoO6, produced by two different methods are compared. The low field magnetoresistance effect at room temperature reaches a value of 10% in a field of 425 mT in samples prepared by combustion synthesis, whereas a field of 1110 mT is required for the same magnetoresistance in samples prepared by solid state reaction. The proportion of Fe/Mo antisite defects, determined by Mössbauer spectroscopy, is twice as great for the former as for the latter, and influences both the magnetic and magnetoresistive properties. The valence state of iron ions in different cation neighbor environments in (Ba1.6Sr0.4)FeMoO6, evaluated from the Mössbauer hyperfine parameters, is consistent with that found for a series of other isostructural iron-based double perovskites.
Strained SOI/SGOI dual-channel CMOS technology based on the Ge condensation technique (2006)

In this paper, fabrication of the dual channel CMOS devices based on the Ge-condensation technique is demonstrated as well as their mobility and current drive enhancements. Ge-rich strained SGOI pMOSFETs were integrated with strained Si/SGOI nMOSFETs by a CMOS process combined with the Ge condensation process, in which the strain in the SGOI layers were properly controlled. As a result, significant electron- and hole-mobility enhancements for the strained SOI and SGOI channels were observed as well as Id enhancements
Amino‐termined poly(<scp>L</scp>‐lactide)s as initiators for the polymerization of <i>N</i>‐carboxyanhydrides: synthesis of poly(<scp>L</scp>‐lactide)‐<i>block</i>‐poly(α‐amino acid)s (1995)

Abstract Poly( L ‐lactide)‐ block‐ poly( L ‐amino acids) block copolymers were prepared via polymerization of α‐amino acid N ‐carboxyanhydrides with amino‐terminated poly( L ‐lactide)s as macroinitiators. Two types of macroinitiators were used, one with an aminopropoxy head group (number‐average molecular weight M n = 22000) and the other one with a phenylalanine end group ( M n = 18000). The first macroinitiator was obtained by polymerization of ( L , L )‐lactide with an initiator prepared in situ from diethylzinc Et 2 Zn and N‐tert ‐butoxycarbonyl‐1‐amino‐3‐propanol, followed by deprotection of the amino group. The second macroinitiator was obtained by endcapping of poly( L ‐lactide) with N‐tert ‐butoxycarbonylphenylalanine and deprotection of the amino group. 1 H‐ and 13 C NMR spectroscopies confirm the block structure of the copolymers obtained. In differential scanning calorimetry curves only one melting transition characteristic of the poly( L ‐lactide) block is observed, on further heating decomposition occurs. By thermogravimetry two steps of decomposition are observed, the first one being assigned to the decomposition of the poly( L ‐lactide) block, and the second one to that of the poly(amino acid) block, by comparison with the thermal behaviour of the corresponding homopolymers.
Sensor for Thermal Gas Analysis Based on Micromachined Silicon-Microwires (2013)

We present a microelectromechanical systems-based sensor for the thermal detection of changes of gas mixtures such as the CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> concentration in air that is of interest in air conditioning climate control within buildings. Key properties of the system are low power consumption (<; 10 mW) and high long-term stability through the absence of moving or consumptive components. The used sensor chip has three silicon-microwires (thermistors) surrounded by the gas mixture to be analyzed. A centered wire (heater) is supplied with sinusoidal heating power. This induces a thermal response via the surrounding gas to measurement wires (detectors) located in different distances from the heater. The phase shift between heating power and induced thermal responses at the detectors is analyzed and depends on the thermal properties of the gas. After calibration, the sensor is able to quantify the concentration of an individual component within a mixture of different but known gas components. This is demonstrated by measuring the CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> concentration in N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> mixtures with a resolution of 0.2% at constant pressure and temperature.
Biologically active fibroblast growth factor 1 tagged with various epitopes (2008)

Tagged FGF1s should be useful for investigating the dynamic behavior of FGF1 in the context of its three-member signaling complex and other molecular complexes.
Economic-based vs. nature-inspired intruder detection in sensor networks (2008)

Protecting computer networks from accidental and malicious harm is a critical issue. Researchers have sought a variety of solutions ranging from the purely statistical approach to approaches inspired from a variety of fields such as economics and biology. In this paper, we focus on the issue of intruder detection and propose two complementary approaches, one economics-based, the other biology-inspired. We discuss the effectiveness of these two approaches put together as compared to each one alone based on Matlab simulations.
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury (2005)

The inhibitor of NF-kappaB (I-kappaB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-kappaB essential modulator (NEMO), and is involved in the activation of NF-kappaB by various stimuli. IKK2 or NEMO constitutive knockout mice die during embryogenesis as a result of massive hepatic apoptosis. Therefore, we examined the role of IKK2 in TNF-induced apoptosis and ischemia/reperfusion (I/R) injury in the liver by using conditional knockout mice. Hepatocyte-specific ablation of IKK2 did not lead to impaired activation of NF-kappaB or increased apoptosis after TNF-alpha stimulation whereas conditional NEMO knockout resulted in complete block of NF-kappaB activation and massive hepatocyte apoptosis. In a model of partial hepatic I/R injury, mice lacking IKK2 in hepatocytes displayed significantly reduced liver necrosis and inflammation than wild-type mice. AS602868, a novel chemical inhibitor of IKK2, protected mice from liver injury due to I/R without sensitizing them toward TNF-induced apoptosis and could therefore emerge as a new pharmacological therapy for liver resection, hemorrhagic shock, or transplantation surgery.
Growth Hormone-Induced Tyrosine Phosphorylation of EGF Receptor as an Essential Element Leading to MAP Kinase Activation and Gene Expression (1998)

GH binding to its receptor, which belongs to the cytokine receptor superfamily, activates Janus kinase (JAK) 2 tyrosine kinase, thereby activating a number of intracellular key proteins such as STAT (signal transducers and activators of transcription) proteins and mitogen-activated protein (MAP) kinases, which finally lead to GH's biological actions including gene expression. In contrast to receptor tyrosine kinases, the signalling pathways leading to MAP kinase activation by GH are poorly understood but appear to involve Grb2 and Shc. We now show that GH stimulated tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and its association with Grb2, and concomitantly stimulated MAP kinase activity in liver, a major target tissue. Expression of EGFR and its mutants into CHO-GH receptor (GHR) cells revealed that GH-induced full activation of MAP kinase and c-fos expression required tyrosine phosphorylation sites of EGFR but not its intrinsic tyrosine kinase activity. Moreover, by also using dominant negative JAK2 and in vitro kinase assay, we demonstrated that tyrosine 1068 of EGFR was evidently one of the major phosphorylation and Grb2 binding sites stimulated by GH via JAK2. These data suggest that the role of EGFR in GH signalling is to be phosphorylated by JAK2, thereby providing docking sites for Grb2 and activating MAP kinases and gene expression. This novel cross talk pathway may provide the first example of the hormone and cytokine receptor superfamily transducing signals via associated nonreceptor tyrosine kinase by phosphorylating growth factor receptor and utilizing it as a docking protein independent of its receptor tyrosine kinase activity.
Biodegradable electrospun patch containing cell adhesion or antimicrobial compounds for trachea repair <i>in vivo</i> (2019)

Difficulty breathing due to tracheal stenosis (i.e. narrowed airway) diminishes the quality of life and can potentially be life-threatening. Tracheal stenosis can be caused by congenital anomalies, external trauma, infection, intubation-related injury, and tumors. Common treatment methods for tracheal stenosis requiring surgical intervention include end-to-end anastomosis, slide tracheoplasty and/or laryngotracheal reconstruction. Although the current methods have demonstrated promise for treatment of tracheal stenosis, a clear need exists for the development of new biomaterials that can hold the trachea open after the stenosed region has been surgically opened, and that can support healing without the need to harvest autologous tissue from the patient. The current study therefore evaluated the use of electrospun nanofiber scaffolds encapsulating 3D-printed PCL rings to patch induced defects in rabbit tracheas. The nanofibers were a blend of polycaprolactone (PCL) and polylactide-co-caprolactone (PLCL), and encapsulated either the cell adhesion peptide, RGD, or antimicrobial compound, ceragenin-131 (CSA). Blank PCL/PLCL and PCL were employed as control groups. Electrospun patches were evaluated in a rabbit tracheal defect model for 12 weeks, which demonstrated re-epithelialization of the luminal side of the defect. No significant difference in lumen volume was observed for the PCL/PLCL patches compared to the uninjured positive control. Only the RGD group did not lead to a significant decrease in the minimum cross-sectional area compared to the uninjured positive control. CSA reduced bacteria growth in vitro, but did not add clear value in vivo. Adequate tissue in-growth into the patches and minimal tissue overgrowth was observed inside the patch material. Areas of future investigation include tuning the material degradation time to balance cell adhesion and structural integrity.
Wheat IgE-Mediated Food Allergy in European Patients: α-Amylase Inhibitors, Lipid Transfer Proteins and Low-Molecular-Weight Glutenins (2007)

The alpha-amylase inhibitor was confirmed to be the most important wheat allergen in food allergy and to play a role in wheat-dependent exercise-induced anaphylaxis, too. Other important allergens were LTP and the LMW glutenin subunits.
Laser Vibration Depot Inspection Of Gear Boxes (1987)

<div class="htmlview paragraph">Due to U. S. Army depot inspection hardware limitations and the Army goal to overhaul equipment in the most efficient and cost-effective manner, the U. S. Army Tank-Automotive Command (TACOM) in conjunction with Tooele Army Depot (TEAD) and Mechanical Technology, Inc. (MTI), initiated a program to develop a transmission and transfer case production inspection test system. The test system was to be designed for both final acceptance inspection and preoverhaul testing to identify internal component quality and wear levels. The system design included automatic evaluation of characteristic vibration frequencies, both from the gear meshes and bearings, and the transient vibration response measured during gear shift operation. Because of the request by depot personnel to minimize test preparation time, a noncontact sensing approach, utilizing laser vibration measurement, was selected for use by the inspection system. The equipment nomenclature was, therefore, defined as the Laser Vibration Sensor Inspection Test System (LVS/ITS). The development program was then laid out to maximize depot personnel involvement during the LVS/ITS design definition phase and to fully utilize the depot personnel's knowledge on the most common failure mechanisms of transmissions and transfer cases. Phase I of the LVS/ITS development program successfully verified the feasibility of, and defined dual technologies for, gear box diagnostic/prognostic test logic and the Laser Vibration Inspection System design specifications.</div>
Matrix metalloproteinases and their inhibitors in canine mammary tumors (2011)

Our findings suggest that MMP-9, MMP-2 and MT1-MMP, which are synthesized by epithelial cancer cells and cancer-associated fibroblasts, play an important role in malignant canine mammary tumors. The reduction of MMP-13 and TIMP-2 could also be a significant step in malignant transformation. MMP-2 and MT1-MMP could be further evaluated as future biomarkers for predicting the progression and prognosis of canine mammary tumors.
HGG-02. DIANHYDROGALACTITOL (VAL-083) OVERCOMES MGMT- AND P53-MEDIATED CHEMO-RESISTANCE AND DISPLAYS SYNERGY WITH TOPOISOMERASE INHIBITORS (2017)

The mortality rate of pediatric CNS cancer has not decreased as other pediatric cancers, and high-grade gliomas (HGG) are the main cause of death in children with brain tumors. Children with HGG have few therapeutic options and 5-year survival is less than 20%. Relapsed HGG have a uniformly fatal outcome despite all available treatments. The standard treatment for HGG is surgery followed by radiotherapy and temozolomide (TMZ) although the efficacy of TMZ in children is negligible. DNA repair protein O6-Methyl-Guanine-DNA-MethylTransferase (MGMT) is expressed in most pediatric HGG and expression is correlated with resistance to TMZ and nitrosoureas and dismal prognosis. VAL-083 is a bi-functional alkylating agent that readily crosses the blood-brain barrier and has demonstrated activity in pediatric brain tumors as well as a favorable safety profile in prior NCI-sponsored clinical trials. VAL-083 induces interstrand cross-links at guanine-N7 causing DNA double-strand breaks and cancer cell death. VAL-083 overcomes TMZ-resistance and is equally active against GBM cancer stem cells (CSCs) and non-CSCs independent of MGMT status, in vitro. We recently showed that VAL-083 leads to irreversible S/G2-phase cell cycle arrest and persistent activation of the homologous recombination DNA repair pathway. This mechanism-of-action of VAL-083 suggests the potential for synergy with topoisomerase inhibitors (TOPi), commonly used in the treatment of pediatric HGG, which require cancer cells to be in S-phase for optimal efficacy. Here, VAL-083 cytotoxicity and DNA damage-response was evaluated in SF188, Med8a, A549 and PC3 cell-lines. We report strong activity in p53-mutated Med8a and SF188 cells known to be radio- and chemo-resistant. Further, we report synergy between VAL-083 and both topoisomerase I and II inhibitors (camptothecin and etoposide) in both A549 and PC3 cell-lines. Our results support a distinct anti-cancer mechanism for VAL-083 compared to standard HGG chemotherapy, resulting in the ability to overcome chemo-resistance and exhibiting synergy with TOPi.
Characterization of a Serodiagnostic Complement Fixation Antigen of <i>Coccidioides posadasii</i> Expressed in the Nonpathogenic Fungus <i>Uncinocarpus reesii</i> (2005)

Coccidioides spp. (immitis and posadasii) are the causative agents of human coccidioidomycosis. In this study, we developed a novel system to overexpress coccidioidal proteins in a nonpathogenic fungus, Uncinocarpus reesii, which is closely related to Coccidioides. A promoter derived from the heat shock protein gene (HSP60) of Coccidioides posadasii was used to control the transcription of the inserted gene in the constructed coccidioidal protein expression vector (pCE). The chitinase gene (CTS1) of C. posadasii, which encodes the complement fixation antigen, was expressed using this system. The recombinant Cts1 protein (rCts1(Ur)) was induced in pCE-CTS1-transformed U. reesii by elevating the cultivation temperature. The isolated rCts1(Ur) showed chitinolytic activity that was identical to that of the native protein and had serodiagnostic efficacy comparable to those of the commercially available antigens in immunodiffusion-complement fixation tests. Using the purified rCts1(Ur), 74 out of the 77 coccidioidomycosis patients examined (96.1%) were positively identified by enzyme-linked immunosorbent assay. The rCts1(Ur) protein showed higher chitinolytic activity and slightly greater seroreactivity than the bacterially expressed recombinant Cts1. These data suggest that this novel expression system is a useful tool to produce coccidioidal antigens for use as diagnostic antigens.
Contextual anomaly detection framework for big sensor data (2015)

The ability to detect and process anomalies for Big Data in real-time is a difficult task. The volume and velocity of the data within many systems makes it difficult for typical algorithms to scale and retain their real-time characteristics. The pervasiveness of data combined with the problem that many existing algorithms only consider the content of the data source; e.g. a sensor reading itself without concern for its context, leaves room for potential improvement. The proposed work defines a contextual anomaly detection framework. It is composed of two distinct steps: content detection and context detection. The content detector is used to determine anomalies in real-time, while possibly, and likely, identifying false positives. The context detector is used to prune the output of the content detector, identifying those anomalies which are considered both content and contextually anomalous. The context detector utilizes the concept of profiles, which are groups of similarly grouped data points generated by a multivariate clustering algorithm. The research has been evaluated against two real-world sensor datasets provided by a local company in Brampton, Canada. Additionally, the framework has been evaluated against the open-source Dodgers dataset, available at the UCI machine learning repository, and against the R statistical toolbox.