gebhart/patrepeval huggingface dataset:
Immunomagnetic separation of adult human olfactory neural progenitors (2005)

Olfactory neuroepithelium (ONe) has lifelong regenerative capacity owing to the presence of mitotically active progenitors. The accessibility of ONe makes it a unique source of progenitors for cell replacement strategies in the CNS. We have established lines of neurosphere forming cells (NSFCs) from adult postmortem ONe and patients undergoing nasal sinus surgery by endoscopic biopsy. These heterogeneous lines are composed primarily of an immature neuronally restricted and a small glial restricted subpopulation. More homogeneous subpopulations of the NSFCs are essential for detailed study of factors influencing their lineage restriction. Immunomagnetic bead separation using an antibody against tyrosine kinase (Trk) receptors (Trk-pan, which recognizes Trk-A, B, C) resulted in viable, enriched positive and negative subpopulations that could be analyzed immunocytochemically. The positive cells remained positive for the first week after which the number of Trk-pan expressing cells decreased. The negative subpopulation began to express Trk-pan immunoreactivity after five days in vitro. Both subpopulations reverted to the heterogeneous composition after two weeks. Furthermore, most NSFCs were positive for Trk-B, a few for Trk-A, while no reactivity was observed for Trk-C. Because NSFCs produce brain derived neurotrophic factor (BDNF) and express Trk B, the specific receptor for BDNF, it is likely that population dynamics are under a paracrine and/or autocrine regulatory mechanism. Lineage restriction analysis demonstrated that the isolated subpopulation had a restriction potential equivalent to the original heterogeneous population. These studies characterize further the NSFCs and support the future potential therapeutic use of ONe-derived progenitors for CNS injury and neurodegenerative disorders.
Comparative Efficacy of “Specific” Potassium Citrate Therapy Versus Conservative Management in Nephrolithiasis of Mild to Moderate Severity (1985)

It generally is believed that conservative measures of high fluid intake and dietary modification in the setting of a stone clinic could favorably influence the course of renal stone disease. To establish the effect of specific medical treatment from the stone clinic effect, we compared the results of potassium citrate therapy to those of 11 reported conservative or placebo trials. The 54 patients receiving potassium citrate chosen for this comparison had mild to moderately severe stone disease (less than 1 stone per patient per year), similar to that encountered in conservative placebo trials (mean 0.54 stones per patient per year). New stone formation was virtually eliminated by potassium citrate therapy (a decrease from 0.52 to 0.02 stones per patient per year, a remission rate of 96 per cent, p less than 0.001), whereas it continued in 39 per cent of the patients during conservative or placebo trials. However, in patients participating in conservative or placebo trials new stone formation decreased by only 54 per cent (from 0.54 to 0.25 stones per patient per year). The superior response to potassium citrate suggested that this specific medical treatment exerted an additional favorable effect on the course of stone disease above the stone clinic effect.
A single-mode fiber evanescent grating reflector (1985)

Backward wave coupling is demonstrated by placing a first-order metal grating in the evanscent field of a single-mode fiber. Guided reflections as high as 38 percent were observed. The device acts as a polarization and frequency filter for both reflected and transmitted light. Polarization extinction ratios greater than 20 and 15 dB were obtained for reflected and transmitted light, respectively.
Targeting Angiogenesis: A therapeutic approach using a synthetic derived peptide (2010)

Angiogenesis plays a critical role in processes such as organ development, wound healing, and tumor growth. It requires well‐orchestrated integration of soluble and matrix factors and timely recognition of such signals to regulate this process. Previous work has shown that endothelial cells express CXC receptor 3 (CXCR3) late in wound regeneration, and upon ligandation by IP‐10 (CXCL10) new vessels are prevented and immature vessels involute. To develop new therapeutic agents to inhibit or collapse blood vessel formation and/or involution of newly forming vessels we isolated a 21 amino acid fragment, residues 78–98, which we modeled to be the functional domain of IP‐10 (IP10p) and analyzed its ability to modulate endothelial cell tube formation. Treatment of the endothelial cells with the IP‐10 peptide significantly inhibited VEGF‐induced endothelial motility and tube formation, a response critical for angiogenesis. [Using an in vivo Matrigel assay we show that the IP‐10p is able to inhibit vessel formation and induce vessel dissociation] Furthermore, stimulation of CXCR3 by the IP‐10 or the IP‐10 peptide induced an increase in cAMP production and activation of PKA that leads to the inhibition of VEGF‐mediated m‐calpain activation and thereby limits cell motility. We propose that this peptide provides a novel reagent that inhibits endothelial signaling pathway thus, allowing for the modulation angiogenesis.
<title>Using data mining to find bent-double radio galaxies in the FIRST survey</title> (2001)

In this paper, we describe the use of data mining techniques to search for radio-emitting galaxies with a bent-double morphology. In the past, astronomers from the FIRST (Faint Images of the Radio Sky at Twenty-cm) survey identified these galaxies through visual inspection. This was not only subjective but also tedious as the on-going survey now covers 8000 square degrees, with each square degree containing about 90 galaxies. In this paper, we describe how data mining can be used to automate the identification of these galaxies. We discuss the challenges faced in defining meaningful features that represent the shape of a galaxy and our experiences with ensembles of decision trees for the classification of bent-double galaxies.
A new gate oxide lifetime prediction method using cumulative damage law and its applications to plasma-damaged oxides (2002)

The Cumulative Damage Law for the electrical stress, which correlates charge-to-breakdown with constant current injection (Q/sub bd/) to time-to-breakdown with constant-voltage stress (t/sub bd/), is theoretically derived from the defect generation model. Based on this law, we propose a new gate oxide lifetime prediction method. Although in some cases, the degradation of gate oxide induced by the plasma and ion implantation processes can not be distinguished by t/sub bd/ measurement, the new method allows an accurate and relevant evaluation of process-induced gate oxide degradation.
MicroRNAs as a Potential Quality Measurement Tool of Platelet Concentrate Stored in Blood Banks—A Review (2019)

The studies described in this review relate the functions of miRNAs with molecular mechanisms that result in functional platelet differences, such as apoptosis. Thus, miRNA profiles can be used to measure the quality of storage PC for more than 5 days, identify bags with platelet injury, and distinguish those with functional platelets.
Field Testing and Characterization of a Transmitter-receiver System for Surface to Borehole Electromagnetic Surveys (2015)

Summary A prototype data acquisition system and surface high power source have been implemented to perform surface to borehole electromagnetic (EM) measurements. The system has been field tested and characterized evaluating background noise, source stability and downhole profiles of the signals excited using the surface source. Background measurements yield amplitudes ∼10-6 V/m and ∼4 10-4 nT for the electric and magnetic field recordings in the frequency range of 8–12 Hz, of interest to STB-EM. The stability of the source waveform was measured to better than 1% and better than 1 degree in amplitude and phase, within a time window (2 minutes) expected for STB-EM logging. Measured downhole vertical profiles repeat better than 2% and 2 degrees in amplitude and phase. The data yields the response of the formation as well as the distorting effect of the metallic casing and wireline above the receivers. The latter was further analyzed by comparing it to numerical simulations performed under representative conditions, including a resistive formation, a conductive borehole and the metallic infrastructure.
Abstract 16457: Transplantation of Human Induced Pluripotent Stem Cells Derived Cardiac Cells for Cardiac Repair (2012)

Objective: We investigated cardiac functional improvements using three distinct human induced pluripoent stem cells (hiPSCs)-derived cell populations. Methods: Cardiac myocytes (CMs), endothelial c...
Ammoxidation of ethane to acetonitrile over Co-beta zeolite (1997)

Y. Li and J. N. Armor, Chem. Commun., 1997, 2013 DOI: 10.1039/A703788K
Directional solidification and characterization of Hg(1-x)Cd(x)Te alloys (1982)

A series of Hg(1-x)Cd(x)Te alloy crystals was grown by high temperature gradient directional solidification at furnace translation rates ranging from 0.068 to 1.12 microns/s. For several ingots, the measured longitudinal compositional profiles were fitted to theoretical profiles to estimate the magnitude of D, the liquid HgTe-CdTe interdiffusion coefficient. The best-fit value of D was about 550,000 sq cm/s. The majority of the ingots showed significant radial compositional variations along the growth axis. These variations are attributed, at least in part, to fluid flows ahead of the growth interface. The results are discussed in terms of the heat transfer characteristics of the alloy/ampule/furnace system, and on the effects of these characteristics on the shape and stability of the growth interface in a 1-g environment.
New processing techniques for the production of pressureless sintered SiC parts (1995)

For the preparation of SiC parts by casting techniques two different processes for the precipitation of sintering aids onto the surface of sub-micron SiC powder have been developed. In the first case, SiC particles were electrostatically coated with nano scaled carbon. In the second case, SiC has been surface modified to provide coupling groups for the subsequent chemical bonding of carbon. The results show that aqueous slips could be prepared which show no segregation for carbon during slip casting. Green parts ( p > 58%) with a homogeneous distribution of carbon additive have been obtained. As a consequence, samples could be pressureless sintered to high densities (> 98,5%), exhibiting a high fracture strength (>450 MPa) and a high Weibull modulus (>10).
Subcarrier multiplexing with dispersion reduction (1995)

A novel dispersion-reduction technique using subcarrier multiplexing and optical prefiltering is described. Measured results from a data link demonstrate that a pair of independent 2.5 Gbit/s data channels can be transmitted over ≥100 km of ordinary singlemode fibre-optic cable at 1550 nm with negligible dispersion.
Tensoresistive PVC Coating for Sensor-Enabled Geogrids (2013)

A study has been conducted to develop a new generation of geosynthetic materials based on the tensoresistivity of polymers filled with electrically conducting particles. These materials, called sensor-enabled geosynthetics (SEGs), allow their tensile strains to be measured without the need for conventional instrumentation (e.g., strain gauges). This paper reports a recent SEG development in which tensoresistive composites made of carbon black–filled plasticized PVC were formulated for the coating of polyester yarns, which are commonly used in commercially manufactured geogrids. Hence, the resulting geogrids are termed sensor-enabled geogrids (SEGGs). The effectiveness of three different blending methods to form the tensoresistive composites was examined by using the statistical consistency of the corresponding electrical conductivity results. The viscosity and stiffness of the resulting materials were measured to evaluate their pliability for industrial production purposes. In addition, a series of tensile and tensoresistivity tests was conducted on tensoresistive coating specimens to study their tensile properties and strain-sensitivity responses. Results of the study show that the coating material is suitable to measure tensile strains in geogrids.
Field emission display using self-aligned carbon nanotube field emitters (2002)

We have obtained uniform field emission quality in a 5" active area by applying gate bias of 75 V, and the brightness is about 240 cd/cm/sup 2/ under an anode bias voltage of 1.5 kV. The triode structure is fabricated by normal thin film processing and carbon nanotube tips are made by the screen printing method and photolithography. The low driving voltage property and the self-aligned thick film process of carbon nanotubes have strong potential for future emissive display development.
GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins (2008)

GPIHBP1, a small glycosylphosphatidylinositol-anchored glycoprotein, is required for the lipolytic processing of triglyceride-rich lipoproteins. GPIHBP1 knockout mice exhibit chylomicronemia, even on a low-fat diet, with plasma triglyceride levels of 3,500-5,000 mg/dl. GPIHBP1 is expressed highly in heart, adipose tissue, and skeletal muscle, the same tissues that express high levels of lipoprotein lipase (LPL). In each of these tissues, GPIHBP1 is located in capillary endothelial cells. Chinese hamster ovary (CHO) cells transfected with a GPIHBP1 expression vector bind LPL and chylomicrons avidly. The expression of GPIHBP1 in mice is modulated by fasting and refeeding and is also regulated by peroxisome proliferator-activated receptor (PPAR)gamma agonists. Here, we review recent progress in understanding GPIHBP1 and discuss its role in lipolysis.
Nitride Laser Diodes With Nonepitaxial Cladding Layers (2010)

Semiconductor laser diodes (LDs) typically use lattice-matched epitaxial layers as waveguide cladding materials. We describe a new LD architecture in which the upper cladding layer is replaced with an evaporated or sputtered nonepitaxial material. Designs and results are presented for 415-nm InGaN LDs that use indium tin oxide, silver, or a silver-palladium-copper alloy as the cladding material, chosen because the material exhibits requisite optical and electrical properties. The nonepitaxial cladding layer offers several advantages, such as eliminating the need to expose vulnerable InGaN active layers to the high temperatures required for growing conventional p-AlGaN cladding layers subsequent to the active layer growth.
Amplification of a Novel v- <i>erb</i> B-Related Gene in a Human Mammary Carcinoma (1985)

The cellular gene encoding the receptor for epidermal growth factor (EGF) has considerable homology to the oncogene of avian erythroblastosis virus. In a human mammary carcinoma, a DNA sequence was identified that is related to v-erbB but amplified in a manner that appeared to distinguish it from the gene for the EGF receptor. Molecular cloning of this DNA segment and nucleotide sequence analysis revealed the presence of two putative exons in a DNA segment whose predicted amino acid sequence was closely related to, but different from, the corresponding sequence of the erbB/EGF receptor. Moreover, this DNA segment identified a 5-kilobase transcript distinct from the transcripts of the EGF receptor gene. Thus, a new member of the tyrosine kinase proto-oncogene family has been identified on the basis of its amplification in a human mammary carcinoma.
Ruggedized high temperature piezoresistive transducers (2001)

In recent years, the need for semiconductor pressure transducers that can be used in applications that require operation in harsh environments that are corrosive, oxidizing, experiencing high vibration, and involving high temperatures has increased. Accordingly, not only must the stress-sensing network of these transducers be protected from these harsh environmental conditions in some way to enable the transducer to remain operational at high temperature over extended period of time, but the entire transducer structure, including: electrical contacts, lead-outs, interconnects and external wiring must also be protected. A method for fabricating and assembling such a leadless device has been introduced and is presented in this paper.
Design of a Robotic Stereotactic Device for Biopsy and Minimally Invasive Interventions in the Breast With Real Time MRI Guidance (2002)

The objective of this work was to develop a robotic device to perform biopsy and therapeutic interventions in the breast with real-time MRI guidance. This is the first US made surgical robotic device to perform real time MR-guided interventions in the breast. The device was designed to allow for (i) conditioning of the breast by compression, (ii) definition of the interventional probe trajectory, by setting the height and pitch of a probe insertion apparatus, and (iii) positioning of an interventional probe by setting the depth of insertion. The apparatus is fitted with five computer-controlled degrees of freedom for delivering an interventional procedure. The entire device is constructed of MR compatible materials, i.e. non-magnetic and non-conductive, to eliminate artifacts and distortion of the local magnetic field. The apparatus is remotely controlled by means of ultrasonic actuators and a graphical user interface, providing real-time MR-guided planning and monitoring of the operation.
A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A (2018)

The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic. Due to these limitations, a recombinant monoclonal antibody (mAb) product is preferable. It has been shown that combining three mAbs that bind non-overlapping epitopes leads to highly potent botulinum neurotoxin (BoNT) neutralization. Recently, a triple human antibody combination for BoNT/A has demonstrated potent toxin neutralization in mouse models with no serious adverse events when tested in a Phase I clinical trial. However, a triple antibody therapeutic poses unique development and manufacturing challenges. Thus, potentially to streamline development of BoNT antitoxins, we sought to achieve the potency of multiple mAb combinations in a single IgG-based molecule that has a long serum half-life. The design, production, and testing of a single tri-epitopic IgG1-based mAb (TeAb) containing the binding sites of each of the three parental BoNT/A mAbs yielded an antibody of nearly equal potency to the combination. The approach taken here could be applied to the design and creation of other multivalent antibodies that could be used for a variety of applications, including toxin elimination.
A System for Privacy-Aware Resource Allocation and Data Processing in Dynamic Environments (2006)

In this paper we describe a system for allocating computational resources to distributed applications and services (within distributed data centres and utility computing systems) in order to perform operations on personal or confidential data in a way that is compliant with associated privacy policies. Relevant privacy policies are selected on the fly, based on related meta-policies, depending on contextual information (potentially including location) and properties of the resources. One or more Trusted Privacy Services are involved to mediate the access to the data, based on the satisfaction of pertinent policies. Resources might be equipped with trusted computing components (e.g. Trusted Platform Modules []) to provide higher assurance and trust about the contextual statements or properties of these resources (such as their location, their status and integrity, etc.).
Adaptive output feedback control of nonlinear systems using neural networks (2000)

An adaptive output feedback controller design procedure for uncertain nonlinear systems is developed which avoids the use of state estimation. To achieve this goal three separate problems are addressed independently: controller design, derivation of parameter update laws and approximate mapping of an unknown dynamic function from its input/output history. To handle the uncertainty, the controller, in the form of a dynamic compensator, is augmented by a single hidden layer (SHL) neural network that adjusts online for unknown nonlinearities. The parameter update laws for a SHL neural network are derived from stability analysis. Simulations illustrate the theoretical results.
P16.21: Estimation of prenatal aorta intima‐media thickness in ultrasound examination (2012)

The aim of this study is to introduce an automatic algorithm that identifies abdominal aorta and estimates its diameter and aorta intima media thickness (aIMT) from videos recorded during routine third trimester ultrasonographic fetal biometry aIMT was measured in singleton pregnant women during routine third trimester ultrasonography. In each frame, the algorithm locates and segments the region corresponding to aorta by means of an active contour driven by two different external forces: a static vector field convolution force and a dynamic pressure force. Then, in each frame, the mean diameter of the vessel is computed, to reconstruct the cardiac cycle: in fact, we expect the diameter to have a sinusoidal trend, according to the heart rate. From the obtained sinusoid, we identified the frames corresponding to the end diastole and to the end systole. Finally, in these frames was assessed the aIMT. The correlation between end-diastole and end-systole aIMT automatic and manual measures is 0.90 and 0.84 respectively. The mean aorta diameter (blue line) and the mean aIMT (red line) estimated in 78 subsequent frames are shown: for visual purpose the values of aIMT are scaled to be superimposed to aorta diameter. The videos were acquired with a frame rate of 25 frames per second, thus three seconds of acquisition are shown. The estimated heart rate in coherent with physiological fetal heart rate. The correlation between end-diastole and end-systole aIMT automatic and manual measures was 0.90 and 0.84 respectively. The high values of correlation between manual and automatic results suggest that the proposed algorithm provides a reliable technique to faster the measure of important structures during ultrasonographic fetal biometry, such as aorta diameter and aIMT. Besides, being fully automatic, it allows avoiding the problems of intra- and inter- operator variability, typical of any manually performed measure.
Production of heterologous proteins using the fission‐yeast (<i>Schizosaccharomyces pombe</i>) expression system (2009)

The fission yeast Schizosaccharomyces pombe is a particularly useful model for studying the function and regulation of genes from higher eukaryotes. The genome of Sc. pombe has been sequenced, and DNA microarray, proteome and transcriptome analyses have been carried out. Among the well-characterized yeast species, Sc. pombe is considered an attractive host for the production of heterologous proteins. Expression vectors for high-level expression in Sc. pombe have been developed and many foreign proteins have been successfully expressed. However, further improvements in the protein-expressing host systems are still required for the production of heterologous proteins involved in post-translational modification, metabolism and intracellular trafficking. This minireview focuses on recent advances in heterologous protein production by use of engineered fission-yeast strains.