gebhart/patrepeval huggingface dataset:
[O2–03–05]: AHA1 ACCELERATES HSP90 ATPASE ACTIVITY TO DRIVE TAU AGGREGATION (2017)

Tau, a microtubule-associated protein, accumulates in the brain of Alzheimer's disease and other tauopathies. Chaperones, such as heat shock protein 90kDa (Hsp90), have been shown to preserve with pathological tau. In fact, we have previously shown that the inhibition of Hsp90 ATPase activity can lower tau levels. The activator of Hsp90 ATPase homolog 1 (Aha1) is the only known stimulator of this ATPase activity, which should directly regulate tau aggregation; however, the effect of Aha1 on Hsp90-mediated tau fibrilization has not been well-characterized. Immunofluorescence for tau and Aha1 colocalization was performed on human brain tissue from normal and AD patients Biochemical analysis of recombinant protein was performed using Thioflavin T (ThT) fluorescence and transmission electron microscopy (TEM). Tet-inducible P301L expressing HEK cells were transfected with Aha1 and tau solubility was determined by Sarkosyl-insoluble preparation. Stereotaxic injections were used to deliver Aha1- or GFP-AAV9 into the hippocampus of rTg4510 tau mice. Immunohistochemistry and biochemistry was performed on brain tissue to evaluate oligomeric and insoluble tau protein levels. Cognitive function was evaluated by 2-day radial arm water maze (RAWM). In human AD brain, we found that Aha1 co-localized with tau pathology and this colocalization correlated with Braak staging. In vitro, Aha1 coordinates with Hsp90 to increase tau fibrilization. Treatment using a novel small molecule inhibitor of Aha1 blocked the formation of insoluble tau. Overexpression of Aha1 in the hippocampus of rTg4510 mice led to an increase in oligomeric and insoluble tau leading to deficits in RAWM. Aha1 promotes tau amyloid formation, which increases not only insoluble but also oligomeric tau leading to cognitive deficits in tau transgenic mouse. These findings highlight Aha1 as an interesting target for future tau-targeted drug development.
A methodology for the production of carbohydrate-specific antibody (1977)

8-Methoxycarbonyloctyl glycosides are recommended as precursors for the preparation of artificial antigens that possess strongly immunodominant carbohydrate antigenic determinants. The preparation and immunochemical properties of a selected number of these antigens are reported to demonstrate the high levels of hapten-specific antibodies that are normally achieved using standard immunization schedules. The method, based on glycoside synthesis, promises to make available a wide spectrum of well defined antigens and the homologous antibodies.
Composite Carbon Molecular Sieve Hollow Fiber Membranes: Resisting Support Densification via Silica Particle Stabilization (2018)

Resisting densification of hollow fiber support layers under high-temperature pyrolysis is critical to form carbon molecular sieve hollow fiber membranes with thin separation layer and attractive productivity. In this paper, a new silica particle stabilization approach is introduced to form thin-skinned composite carbon molecular sieve hollow fiber membranes with excellent resistance to support layer densification. By dispersing small-sized silica particles with low bulk density in the support layer of polymer precursor hollow fibers, composite carbon molecular sieve hollow fiber membranes were formed with highly porous supports. The composite carbon molecular sieve hollow fiber membranes showed very attractive selectivities and productivities higher than those of monolithic asymmetric carbon molecular sieve hollow fiber membranes formed by the standard sol–gel support stabilization technique.
Memristive multistate pipeline register (2014)

Over the past years, new memory technologies such as RRAM, STT-MRAM, and PCM have emerged. These technologies employ devices located within the metal layers of the integrated circuit, which are relatively fast, dense, and power efficient and can be considered as `memristors.' In this paper, we present these emerging memory technologies as enablers to the era of memory-intensive computing, which brings interesting opportunities for novel architectural applications. As an example, we present the multistate pipeline register (MPR), a structure that stores the microarchitectural state of multiple threads. We show that an MPR can eliminate the need to flush the pipeline upon a thread switch in Switch-on-Event (SoE) multi-threading machines. We call the new microarchitectural scheme, Continuous Flow Multi-Threading (CFMT), and compare the performance and power consumption against traditional SoE machines. Memristor-based CFMT exhibits an average performance improvement of 32% while reducing power consumption by 8.5%, thereby significantly increasing the performance to energy ratio.
Confluence of navigation, communication, and control in distributed spacecraft systems (2002)

This research details the development of technologies and methodologies that enable distributed spacecraft systems by supporting integrated navigation, communication, and control. Operating at the confluence of these critical functions produces capabilities needed to realize the promise of distributed spacecraft systems, including improved performance and robustness relative to monolithic space systems. Navigation supports science data association and data alignment for distributed aperture sensing, multipoint observation, and co-observation of target regions. Communication enables autonomous distributed science data processing and information exchange among space assets. Both navigation and communication provide essential input to control methods for coordinating distributed autonomous assets at the interspacecraft system level and the intraspacecraft affector subsystem level. A technology solution to implement these capabilities, the Crosslink Transceiver, is also described. The Crosslink Transceiver provides navigation and communication capability that can be integrated into a developing autonomous command and control methodology for distributed spacecraft systems. A small satellite implementation of the Crosslink Transceiver design is detailed and its ability to support broad distributed spacecraft mission classes is described.
Photo‐aligning by azo‐dyes: Physics and applications (2005)

Liquid crystal photo-alignment using azo-dyes is reviewed. This alignment method is very different from previously reported ones, such as photo-crosslinking, photo degradation and photo-isomerization. It will be shown that this photo-aligning method can provide a controllable pretilt angle and strong anchoring energy of the liquid crystal cell, as well as high thermal and UV stability. The application of this method to the alignment and fabrication of various types of liquid crystal displays is also discussed.
Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality (2011)

The original criteria for NAFLD subtypes and the current study's criteria for NASH were in almost perfect agreement, but their level of agreement with the NAS and Brunt criteria was lower. A diagnosis of NASH by the original criteria for NAFLD subtypes demonstrated the best predictability for LRM in NAFLD patients.
<i>Listeria</i>-based cancer vaccines that segregate immunogenicity from toxicity (2004)

The facultative intracellular bacterium Listeria monocytogenes is being developed as a cancer vaccine platform because of its ability to induce potent innate and adaptive immunity. For successful clinical application, it is essential to develop a Listeria platform strain that is safe yet retains the potency of vaccines based on wild-type bacteria. Here, we report the development of a recombinant live-attenuated vaccine platform strain that retains the potency of the fully virulent pathogen, combined with a >1,000-fold reduction in toxicity, as compared with wild-type Listeria. By selectively deleting two virulence factors, ActA (DeltaactA) and Internalin B (DeltainlB), the immunopotency of Listeria was maintained and its toxicity was diminished in vivo, largely by blocking the direct internalin B-mediated infection of nonphagocytic cells, such as hepatocytes, and the indirect ActA-mediated infection by cell-to-cell spread from adjacent phagocytic cells. In contrast, infection of phagocytic cells was not affected, leaving intact the ability of Listeria to stimulate innate immunity and to induce antigenspecific cellular responses. Listeria DeltaactA/DeltainlB-based vaccines were rapidly cleared from mice after immunization and induced potent and durable effector and memory T-cell responses with no measurable liver toxicity. Therapeutic vaccination of BALB/c mice bearing murine CT26 colon tumor lung metastases or palpable s.c. tumors (>100 mm(3)) with recombinant Listeria DeltaactA/DeltainlB expressing an endogenous tumor antigen resulted in breaking of self-tolerance and long-term survival. We propose that recombinant Listeria DeltaactA/DeltainlB expressing human tumor-associated antigens represents an attractive therapeutic strategy for further development and testing in human clinical trials.
Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer (2013)

Castrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer. CRPC is characterized by reactivation of the androgen axis due to changes in androgen receptor signaling and/or adaptive intratumoral androgen biosynthesis. AKR1C3 is upregulated in CRPC where it catalyzes the formation of potent androgens. This makes AKR1C3 a target for the treatment of CRPC. AKR1C3 inhibitors should not inhibit AKR1C1/AKR1C2, which inactivate 5α-dihydrotestosterone. Indomethacin, used to inhibit cyclooxygenase, also inhibits AKR1C3 and displays selectivity over AKR1C1/AKR1C2. Parallel synthetic strategies were used to generate libraries of indomethacin analogues, which exhibit reduced cyclooxygenase inhibitory activity but retain AKR1C3 inhibitory potency and selectivity. The lead compounds inhibited AKR1C3 with nanomolar potency, displayed >100-fold selectivity over AKR1C1/AKR1C2, and blocked testosterone formation in LNCaP-AKR1C3 cells. The AKR1C3·NADP(+)·2'-des-methyl-indomethacin crystal structure was determined, and it revealed a unique inhibitor binding mode. The compounds reported are promising agents for the development of therapeutics for CRPC.
Double‐Stranded RNA Viral Infection of<i>Trichomonas vaginalis</i>Infecting Patients Attending a Sexually Transmitted Diseases Clinic (2002)

Trichomonas vaginalis (TV) can be infected with double-stranded RNA (dsRNA) viruses that may have important implications for trichomonal virulence and disease pathogenesis. A cross-sectional study was conducted in a sexually transmitted diseases clinic to determine the prevalence and clinical significance of dsRNA viral infection of TV infecting men and women. Overall, dsRNA virus was present in 21 (75%) of 28 TV isolates (95% confidence interval [CI], 55%-89%). dsRNA viral infection of TV was not associated with the presence of discharge, dysuria, genital pruritus, or genital irritation or odor. However, patients with virus-positive isolates were significantly older than patients with virus-negative isolates (median age, 38 vs. 23 years; P=.003), and virus-positive isolates were more prevalent among women (19 [86%] of 22 isolates; 95% CI, 65%-97%) than among men (2 [33%] of 6 isolates; P=.02). The age and sex specificity of virus-positive isolates may aid in understanding the differences in chronicity and clinical presentation of TV in men and women.
A Comparison of Patient-Controlled Sedation Using Either Remifentanil or Remifentanil-Propofol for Shock Wave Lithotripsy (2001)

The addition of propofol to remifentanil improves patient satisfaction and decreases postoperative nausea and vomiting. However, it causes more respiratory depression than remifentanil alone. When remifentanil-propofol is used with patient-controlled sedation, appropriate monitoring and a minimum 1-2 min lockout interval is required.
Active Stabilization and Continuous Phase Control of Time-bin Entanglement Interferometers* (2014)

We introduce a technique for stabilizing and enabling continuous phase control of fiber-based time-bin entanglement interferometers. This technique reuses the pair creation pump, which coexists with and co-propagates with the entangled photons.
Control of magnetic bearings using the observer for unbalance. (1990)

An unbalance on a rotor causes whirling motions of the rotor and alternating forces of the bearings in rotating machines. The authors have shown a magnetic bearing control system in which an unbalanced rotor can be suspended without whirling. The concept of designing the control system was that the effects of unbalance were estimated by an observer and cancelled by the electro magnetic forces of the bearing. With the control method applied, the position of the rotor can be maintained at the desired position with high precision. It is suitable for some machines, however, to minimize the variation of exciting currents or vibratory force transmitted to the base through the bearing. In this paper, control methods are presented which can eliminate stationary alternating components from exciting currents or electromagnetic forces by using the output of the observer. Another control method is presented which feedback the estimated signals of the displacements of the principal axis ; such signals are obtained by compensating synchronous obsevatory disturbances by use of the output of the observer. It is shown that the proposed three control methods are equivalent when unbalance stiffness due to the bias magnetic flux is null.
Paging Issues and Methods for Multiaccess (2007)

Battery-powered multiaccess devices, with their increased flexibility and reachability, are becoming common. Such devices would have to disassociate their radio accesses from the surrounding networks whenever they are left unused, in order to address battery lifetime limitations. In single-access networks, paging has been proven an effective method for minimizing power consumption. In a heterogeneous multiaccess environment, a paging function may be even more important in extending battery lifetimes. This study investigates the issues at hand, presents related work, analyzes the paging issues in multiaccess scenarios, and proposes two multiaccess paging schemes, which utilize (but do not replace) existing paging functions in access technologies as a foundation to realize multiaccess paging. We further specify how to realize multiaccess paging in Ambient Networks, and present numerical analysis results on the different degrees of battery lifetime savings under different communication, network and device use settings.
Synthesis of four diastereomeric L-2-(carboxycyclopropyl)glycines. Conformationally constrained L-glutamate analogs (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of four diastereomeric L-2-(carboxycyclopropyl)glycines. Conformationally constrained L-glutamate analogsKeiko Shimamoto, Michiko Ishida, Haruhikio Shinozaki, and Yasufumi OhfuneCite this: J. Org. Chem. 1991, 56, 13, 4167–4176Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/jo00013a018https://doi.org/10.1021/jo00013a018research-articleACS PublicationsRequest reuse permissionsArticle Views1413Altmetric-Citations148LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Field Evaluation of an Asymmetric Directional Microphone Fitting (2007)

Laboratory evidence suggests that an asymmetric microphone fitting (omnidirectional processing in one ear and directional processing in the other) can provide a directional advantage in background noise that is as great, or nearly as great, as that provided by binaural directional processing (Bentler et al, 2004). The present study investigated whether the potential benefit of an asymmetric fitting observed in the laboratory extends to real-life listening. Specifically, ease of listening was compared across a variety of real-life listening situations for asymmetric microphone fittings and bilateral omnidirectional processing. These ratings were compared to determine whether the asymmetric fitting provided an advantage in listening situations in which directional microphone processing is generally preferred and/or a disadvantage in listening situations in which omnidirectional microphone processing is generally preferred. Results suggest that an asymmetric fitting may be a viable option for patients who cannot or do not switch microphone modes.
Nitridation of the stacked poly-Si gate to suppress the boron penetration in pMOS (1995)

Nitridation to create nitrogen-rich layers in-between the stacked layers of the poly-Si gate to suppress the boron penetration for pMOS with the gate BF/sub 2//sup +/-implantation is proposed and demonstrated. The MOS capacitors fabricated by using this nitridized stacked poly-Si gate have better thermal stability and much improved electrical characteristics.
Automation and Heat Transfer Characterization of Immersion Mode Spectroscopy for Analysis of Ice Nucleating Particles (2017)

Abstract. Ice nucleating particles (INPs) influence cloud properties and can affect the overall precipitation efficiency. Developing a parameterization of INPs in global climate models has proven challenging. More INP measurements, including studies of their spatial distribution, sources and sinks, and fundamental freezing mechanisms, must be conducted in order to further improve INP parameterizations. In this paper, an immersion mode INP measurement technique is modified and automated using a software-controlled, real-time image stream designed to leverage optical changes of water droplets to detect freezing events. For the first time, heat transfer properties of the INP measurement technique are characterized using a finite-element analysis based heat transfer simulation to improve accuracy of INP freezing temperature measurement. The heat transfer simulation is proposed as a tool that could be used to explain the sources of bias in temperature measurements in INP measurement techniques, and ultimately explain the observed discrepancies in measured INP freezing temperatures between different instruments. The simulation results show that a difference of +5.6 °C between the well base temperature and the headspace gas results in an up to 3 °C stratification of the aliquot, whereas a difference of +3.0 °C or less results in a thermally homogenous water volume within ±0.05 °C. The results also show that there is a strong temperature gradient in the immediate vicinity of the aliquot, such that without careful placement of temperature probes, or characterization of heat transfer properties of the water and cooling environment, INP measurements can be biased toward colder temperatures. Using the modified immersion mode technique, the Automated Ice Spectrometer (AIS), measurements of the standard test dust illite NX are reported and compared against 5 other immersion mode droplet assay techniques featured in (Hiranuma et al. 2015) that used wet suspensions. AIS measurements of illite NX INP freezing temperatures compare reasonably with others, falling within the 5 ºC spread in reported spectra. The AIS and its characterization of heat transfer properties allows higher confidence in accuracy of freezing temperature measurement, higher throughput of sample analysis, and enables disentanglement of the effects of heat transfer rates on sample volumes from time dependence of ice nucleation.
A novel and sensitive method for the detection of T cell stimulatory epitopes of α/β- and γ-gliadin (2004)

A new antibody based method has been developed, detecting the presence of T cell stimulatory gluten peptides. This can be used to further ensure the safety of food consumed by CD patients.
Flat panel detector‐based cone beam computed tomography with a circle‐plus‐two‐arcs data acquisition orbit: Preliminary phantom study (2003)

Cone beam computed tomography (CBCT) has been investigated in the past two decades due to its potential advantages over a fan beam CT. These advantages include (a) great improvement in data acquisition efficiency, spatial resolution, and spatial resolution uniformity, (b) substantially better utilization of x-ray photons generated by the x-ray tube compared to a fan beam CT, and (c) significant advancement in clinical three-dimensional (3D) CT applications. However, most studies of CBCT in the past are focused on cone beam data acquisition theories and reconstruction algorithms. The recent development of x-ray flat panel detectors (FPD) has made CBCT imaging feasible and practical. This paper reports a newly built flat panel detector-based CBCT prototype scanner and presents the results of the preliminary evaluation of the prototype through a phantom study. The prototype consisted of an x-ray tube, a flat panel detector, a GE 8800 CT gantry, a patient table and a computer system. The prototype was constructed by modifying a GE 8800 CT gantry such that both a single-circle cone beam acquisition orbit and a circle-plus-two-arcs orbit can be achieved. With a circle-plus-two-arcs orbit, a complete set of cone beam projection data can be obtained, consisting of a set of circle projections and a set of arc projections. Using the prototype scanner, the set of circle projections were acquired by rotating the x-ray tube and the FPD together on the gantry, and the set of arc projections were obtained by tilting the gantry while the x-ray tube and detector were at the 12 and 6 o'clock positions, respectively. A filtered backprojection exact cone beam reconstruction algorithm based on a circle-plus-two-arcs orbit was used for cone beam reconstruction from both the circle and arc projections. The system was first characterized in terms of the linearity and dynamic range of the detector. Then the uniformity, spatial resolution and low contrast resolution were assessed using different phantoms mainly in the central plane of the cone beam reconstruction. Finally, the reconstruction accuracy of using the circle-plus-two-arcs orbit and its related filtered backprojection cone beam volume CT reconstruction algorithm was evaluated with a specially designed disk phantom. The results obtained using the new cone beam acquisition orbit and the related reconstruction algorithm were compared to those obtained using a single-circle cone beam geometry and Feldkamp's algorithm in terms of reconstruction accuracy. The results of the study demonstrate that the circle-plus-two-arcs cone beam orbit is achievable in practice. Also, the reconstruction accuracy of cone beam reconstruction is significantly improved with the circle-plus-two-arcs orbit and its related exact CB-FPB algorithm, as compared to using a single circle cone beam orbit and Feldkamp's algorithm.