gebhart/patrepeval huggingface dataset:
Tinnitus: A New Management (1978)

Tinnitus Clinic was established at the University of Oregon Medical School and the result of treatment for 158 patients is discussed. Patients received three forms of masking as treatment: masking from hearing aids, masking from the Tinnitus Masker, and FM-Masking. Conditions leading to each kind of recommendation are discussed. The examination procedures used in the Tinnitus Clinic are presented. The phenomenon of residual inhibition is explained and discussed in relation to possible long-term or permanent relief of tinnitus. Future plans for the clinic and needs of tinnitus patients are presented.
Catalytic and regioselective acylation of aromatic heterocycles using carbon monoxide and olefins (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic and regioselective acylation of aromatic heterocycles using carbon monoxide and olefinsEric J. Moore, Wayne R. Pretzer, Todd J. O'Connell, Johnel Harris, Leslie LaBounty, Loretta Chou, and S. Scott GrimmerCite this: J. Am. Chem. Soc. 1992, 114, 14, 5888–5890Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ja00040a078https://doi.org/10.1021/ja00040a078research-articleACS PublicationsRequest reuse permissionsArticle Views2195Altmetric-Citations231LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Flying-Adder PLL technique enabling novel approaches for video/graphic applications (2008)

A flying-adder frequency synthesis architecture has been developed recently. It has many unique features which can not be easily achieved by conventional PLL based techniques, such as very fine frequency resolution, instantaneous response speed, precisely describable frequency transfer function, reduced analog design complexity and etc. These features are especially beneficial to video/graphic applications which often require many frequencies generated on-chip. This Flying-Adder architecture based PLL technique is an enabler which enables many novel approaches to be created for solving various problems in video/graphic environment. This paper demonstrates several such new approaches enabled by this technique.
Open-Flask Synthesis of Amine–Boranes via Tandem Amine–Ammonium Salt Equilibration–Metathesis (2015)

An amine-ammonium salt equilibration-metathesis sequence provides high-purity amine-boranes in excellent yields from sodium borohydride in refluxing reagent-grade tetrahydrofuran in an open flask.
Plant–pathogen microevolution: Molecular basis for the origin of a fungal disease in maize (1998)

A new and severe disease of maize caused by a previously unknown fungal pathogen, Cochliobolus carbonum race 1, was first described in 1938. The molecular events that led to the sudden appearance of this disease are described in this paper. Resistance to C. carbonum race 1 was found to be widespread in maize and is conferred by a pair of unlinked duplicate genes, Hm1 and Hm2. Here, we demonstrate that resistance is the wild-type condition in maize. Two events, a transposon insertion in Hm1 and a deletion in Hm2, led to the loss of resistance, resulting in the origin of a new disease. None of the other plant species tested is susceptible to C. carbonum race 1, and they all possess candidate genes with high homology to Hm1 and Hm2. In sorghum and rice, these homologs map to two chromosomal regions that are syntenic with the maize Hm1 and Hm2 loci, indicating that they are related to the maize genes by vertical descent. These results suggest that the Hm-encoded resistance is of ancient origin and probably is conserved in all grasses.
QUBE (2012)

The betweenness centrality of a vertex in a graph is a measure for the participation of the vertex in the shortest paths in the graph. The Betweenness centrality is widely used in network analyses. Especially in a social network, the recursive computation of the betweenness centralities of vertices is performed for the community detection and finding the influential user in the network. Since a social network graph is frequently updated, it is necessary to update the betweenness centrality efficiently. When a graph is changed, the betweenness centralities of all the vertices should be recomputed from scratch using all the vertices in the graph. To the best of our knowledge, this is the first work that proposes an efficient algorithm which handles the update of the betweenness centralities of vertices in a graph. In this paper, we propose a method that efficiently reduces the search space by finding a candidate set of vertices whose betweenness centralities can be updated and computes their betweenness centeralities using candidate vertices only. As the cost of calculating the betweenness centrality mainly depends on the number of vertices to be considered, the proposed algorithm significantly reduces the cost of calculation. The proposed algorithm allows the transformation of an existing algorithm which does not consider the graph update. Experimental results on large real datasets show that the proposed algorithm speeds up the existing algorithm 2 to 2418 times depending on the dataset.
107 Dose-Finding and Safety Study of an Oncolytic Polio/Rhinovirus Recombinant Against Recurrent Glioblastoma (2013)

INTRODUCTION: Current therapies for glioblastoma are limited by ineffective delivery beyond the blood-brain barrier, limited diffusion of regionally-delivered macromolecules, and lack of tumor specificity. Sustained direct intracerebral infusion at slow flow rates [convection-enhanced delivery (CED)] can overcome delivery barriers. PVSRIPO is the live attenuated, oral (SABIN) serotype 1 poliovirus vaccine containing a heterologous internal ribosomal entry site stemming from human rhinovirus type 2. PVSRIPO recognizes nectin-like molecule-5, an oncofetal cell adhesion molecule and tumor antigen widely expressed ectopically in malignancy. We are reporting results of an ongoing phase I study evaluating PVSRIPO via CED delivery. METHODS: Adult patient eligibility: 1-5 cm of measurable supratentorial recurrent glioblastoma ≥ 1 cm away from the ventricles; ≥ 4 weeks after chemotherapy, bevacizumab or study drug; adequate organ function; KPS ≥ 70%; and positive anti-poliovirus titer. PVSRIPO is delivered intratumorally by CED over 6.5 hours. PVSRIPO dose escalation is accomplished by increasing agent concentration, allowing flow-rate and infusion volume to remain constant. A 2-step continual reassessment method is used for dose escalation, with 1 patient each treated on dose levels 1-4, and a possibility of ≤ 13 patients on dose level 5. RESULTS: Total of 6 patients have been treated. Two grade 3 adverse events were observed. Median PFS is 4.0 months (95% CI: 0.9, “infinity”); median OS not estimable. Six-month PFS is 41.7% (95% CI: 5.6%, 76.7%); 6-month OS is 66.7% (95% CI: 5.4%, 94.5%). Patient #1 failed bevacizumab prior to enrollment and remains disease-free more than 9 months post PVSRIPO. Two patients are disease-free 8+ and 2+ months post treatment, respectively. One had pathology confirmed disease recurrence 2 months post treatment and 1 came off study due to clinical decline 4 months post treatment. CONCLUSION: PVSRIPO infusion via CED is safe thus far with encouraging efficacy results. Updated results will be presented at the meeting.
Design and Synthesis of Sulfamoyl Benzoic Acid Analogues with Subnanomolar Agonist Activity Specific to the LPA<sub>2</sub> Receptor (2014)

Lysophosphatidic acid (LPA) is a growth factor-like mediator and a ligand for multiple GPCR. The LPA2 GPCR mediates antiapoptotic and mucosal barrier-protective effects in the gut. We synthesized sulfamoyl benzoic acid (SBA) analogues that are the first specific agonists of LPA2, some with subnanomolar activity. We developed an experimental SAR that is supported and rationalized by computational docking analysis of the SBA compounds into the LPA2 ligand-binding pocket.
Molecular cloning and characterization of a human brain ryanodine receptor<sup>1</sup> (1997)

We have cloned and sequenced the cDNA of the human brain ryanodine receptor (RyR3), which is composed of 4866 amino acids and shares characteristic structural features with the rabbit RyR3. Northern blot analysis shows that the human RyR3 mRNA is abundantly expressed in hippocampus, caudate nucleus and amygdala as well as in skeletal muscle. The human RyR3 mRNA is also detected in several cell lines derived from human brain tumors. Functional expression of RyR3 and a chimeric RyR suggests that RyR3 forms a calcium-release channel with a very low Ca2+ sensitivity.
Document image decoding by heuristic search (1996)

This correspondence describes an approach to reducing the computational cost of document image decoding by viewing it as a heuristic search problem. The kernel of the approach is a modified dynamic programming (DP) algorithm, called the iterated complete path (ICP) algorithm, that is intended for use with separable source models. A set of heuristic functions are presented for decoding formatted text with ICP. Speedups of 3-25 over DP have been observed when decoding text columns and telephone yellow pages using ICP and the proposed heuristics.
Ultraminiature video-rate forward-view spectrally encoded endoscopy with straight axis configuration (2017)

As one of the smallest endoscopes that have been demonstrated, the spectrally encoded endoscope (SEE) shows potential for the use in minimally invasive surgeries. While the original SEE is designed for side-view applications, the forwardview (FV) scope is more desired by physicians for many clinical applications because it provides a more natural navigation. Several FV SEEs have been designed in the past, which involve either multiple optical elements or one optical element with multiple optically active surfaces. Here we report a complete FV SEE which comprises a rotating illumination probe within a drive cable, a sheath and a window to cover the optics, a customized spectrometer, hardware controllers for both motor control and synchronization, and a software suite to capture, process and store images and videos. In this solution, the optical axis is straight and the dispersion element, i.e. the grating, is designed such that the slightly focused light after the focusing element will be dispersed by the grating, covering forward view angles with high diffraction efficiencies. As such, the illumination probe is fabricated with a diameter of only 275 μm. The twodimensional video-rate image acquisition is realized by rotating the illumination optics at 30 Hz. In one finished design, the scope diameter including the window assembly is 1.2 mm.
Effect of Purification of β-Si<sub>3</sub>N<sub>4</sub> Powder on the Strength of Sintered Materials (1995)

A low purity β-silicon nitride powder for refractory materials was classified or acid treated to remove metallic impurities. The purified powder was gas-pressure sintered at 1900°C for 4h in nitrogen gas of 10 MPa using 4mol% Y2O3-Nd2O3 as sintering aids. Acid treatment decreased the Fe and Ca contents to increase the strength of sintered materials. Powder classification eliminated coarse particles including Fe as well as large silicon nitride particles. As the result, the strength of sintered materials increased up to 843 MPa. Thus, this material can be used as structural components.
Object detection using adaptive block-based background model (2016)

This paper propose an adaptable block-based background modeling and real time image object detection algorithm. In training step, we present adaptable block-based background model that uses major color number to determine the block size. This background model can reduce the memory consumption, efficiently. In detection step, we use one pixel to compare with background model. Then, it can reduce processing time. The experiment results show that we can save 33.9% memory space. Finally, we can achieve 27.25 frames per second for the benchmark video with image size 768×576.
Perpendicular STT-MRAM for high speed non-volatile embedded memory application (2015)

The recent rise of mobile applications such as Internet of Things (IoT), wearable electronics, and context aware computing has renewed the search for a universal embedded memory technology [1]. Such a technology should combine fast read/write, low voltage operation, low power consumption, non-volatility, infinite endurance, with CMOS process compatibility. Magnetic Random Access Memory based on Spin Transfer Torque phenomena (STT-MRAM) has been recognized as a promising candidate. The technology is innately non-volatile, and it has been shown that STT-MRAM based on perpendicularly magnetized Magnetic Tunnel Junctions (MTJs) can be written at high speed with low power. However, two major challenges remain. The first is to design multilayered MTJs that can withstand temperatures used in CMOS backend processing without any degradation of their magnetic properties. The second challenge is that fast read/write must be achieved not only at the single device level, but on entire memory arrays which requires controlling defects and distributions of magnetic properties.
JPEG 2000 Encryption Enabling Fine Granularity Scalability without Decryption (2005)

We propose a novel encryption scheme for JPEG 2000 (J2K) and motion JPEG 2000. A block cipher in CBC mode is used to encrypt the bitstream of each J2K code-block. The encrypted J2K codestream preserves almost the same fine granularity scalability as the original J2K codestream, yet with small or negligible overhead, and has fine and near RD-optimal truncations for a large range of bitrates. The proposed scheme enables desired transcoding directly on a single encrypted codestream without decryption to fit diverse capabilities of devices and heterogeneous networks with time-varying bandwidths. Any node, trusted or not, along the delivery path is able to perform the desired transcoding without sacrificing the end-to-end security of the system.
High Step-Up Ratio Flyback Converter With Active Clamp and Voltage Multiplier (2011)

In this paper, an isolated high step-up ratio dc-dc converter aimed to be used in interface systems between low-voltage renewable energy sources, such as photovoltaic panels and fuel cells and the utility grid, is presented. The converter is based on the active clamp flyback topology with a voltage multiplier at the transformer secondary side. Such configuration, while naturally clamping the rectifier diode voltages thus avoiding the use of dissipative snubber circuits, allows the reduction of the circulating current during the active clamp operation due to the resonance involving the transformer leakage inductances and the diode parasitic capacitances. Experimental results taken from a 300-W-rated prototype are reported, showing the absence of parasitic oscillations after diodes and switch transitions and high efficiency, in agreement with the theoretical expectations.
42.1: <i>Invited Paper:</i> Review of the Properties of Up‐Conversion Phosphors for New Emissive Displays (2004)

Abstract We review the properties of up‐conversion materials which absorb near infrared light and re‐emit in the visible and we assess their potential for a new display technology. Such phosphors have characteristics that are very appealing for displays: they cover a wide color gamut with very saturated colors, they can be operated at very high brightness without damage to the emitters, they have very long lifetimes and they have efficiencies comparable to those of existing technologies.
The Stabilized Soliton Laser (1986)

The soliton laser [1] consists of a synch-pumped, mode-locked color center laser, tunable in the 1.5 μm region, coupled to a second cavity, containing a single mode, polarization preserving optical fiber. (See Fig. 1.) Feedback from the fiber, where pulse compression and soliton formation take place, enables the color center laser to produce transform limited pulses of ~sech 2 intensity profile and of any desired pulse width, down to about 100 fsec, through choice of the control fiber length.
Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity (2002)

We have generated eight mAbs (MW1-8) that bind the epitopes polyglutamine (polyQ), polyproline (polyP), or the C terminus of exon 1 in huntingtin (htt) protein. In the brains of Huntington's disease (HD) mouse models, the anti-polyQ mAbs bind to various cytoplasmic compartments, whereas the anti-polyP and anti-C terminus mAbs bind nuclear inclusions containing htt. To use these mAbs as intracellular perturbation agents, we have cloned and expressed the antigen-binding domains of three of the mAbs as single-chain variable region fragment Abs (scFvs). In 293 cells cotransfected with htt exon 1 containing an expanded polyQ domain, MW1, MW2, and MW7 scFvs colocalize with htt exon 1. Moreover, these scFvs coimmunoprecipitate with htt exon 1 in cell extracts. In perturbation experiments, MW7 scFv, recognizing the polyP domains of htt, significantly inhibits aggregation as well as the cell death induced by mutant htt protein. In contrast, MW1 and MW2 scFvs, recognizing the polyQ stretch, stimulate htt aggregation and apoptosis. Therefore, these anti-htt scFvs can be used to investigate the role of the polyP and polyQ domains in HD pathogenesis, and antibody binding to the polyP domain has potential therapeutic value in HD.
Carbon Nanotube Salts. Arylation of Single‐Wall Carbon Nanotubes. (2005)

Carbon nanotube salts prepared by treating single-wall carbon nanotubes (SWNTs) with lithium in liquid ammonia react readily with aryl\niodides to give SWNTs functionalized by aryl groups.
A Load Sensing Face Form for Automotive Collision Crash Dummy Instrumentation (1986)

<div class="htmlview paragraph">This paper summarizes the development of an Instrumented faceform which can record time histories of impact-related pressures at fifty-two locations over the entire face of a Hybrid 2 crash dummy skull. Pressures are measured by using piezo-electric, thin-plastic films; a high-speed, multiplex data acquisition system; signal conditioning; a software-controlled computerized data reduction and recording scheme; and a submergence calibration technique. The construction of the modified dummy face and the calibration gear are discussed. Examples of preliminary laboratory impact test results are presented. Theory and techniques relating to signal processing software, microprocessor controlled random-access-memory data-retrieval system and system calibration are also discussed. It is hoped that this tool, now undergoing final development and verification testing, will find extensive use in the evaluation and safety-related design of vehicle interiors and occupant restraints.</div>
Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion (2018)

Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ± 24.5 µm) post-extrusion through a three-dimensional (3D) printed methacrylate-based custom hollow microneedle assembly (circular array of 13 conical frusta) fabricated using stereolithography. With a jetting reliability of 80%, the solvent-sterilized device with a root mean square roughness of 158 nm at the extrusion nozzle tip (d = 325 μm) was operated at a flowrate of 12 mL/min. There was no significant difference between the viability of the sheared and control samples for extrusion times of 2 h (p = 0.14, α = 0.05) and 24 h (p = 0.5, α = 0.05) post-atomization. Factoring the increase in extrusion yield from 21.2% to 56.4% attributed to hydrogel bioerosion quantifiable by a loss in resilience from 5470 (J/m³) to 3250 (J/m³), there was no significant difference in percentage relative payload (p = 0.2628, α = 0.05) when extrusion occurred 24 h (12.2 ± 4.9%) when compared to 2 h (9.9 ± 2.8%) post-atomization. Results from this paper highlight the feasibility of encapsulated cell extrusion, specifically protection from shear, through a hollow microneedle assembly reported for the first time in literature.
Detection of CTNNB1 Hotspot Mutations in Cell-Free DNA from the Urine of Hepatocellular Carcinoma Patients (2021)

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. The beta-catenin gene, <i>CTNNB1,</i> is among the most frequently mutated in HCC tissues. However, mutational analysis of HCC tumors is hampered by the difficulty of obtaining tissue samples using traditional biopsy. Here, we explored the feasibility of detecting tumor-derived <i>CTNNB1</i> mutations in cell-free DNA (cfDNA) extracted from the urine of HCC patients. Using a short amplicon qPCR assay targeting HCC mutational hotspot <i>CTNNB1</i> codons 32-37 (exon 3), we detected <i>CTNNB1</i> mutations in 25% (18/73) of HCC tissues and 24% (15/62) of pre-operative HCC urine samples in two independent cohorts. Among the CTNNB1-mutation-positive patients with available matched pre- and post-operative urine (<i>n</i> = 13), nine showed apparent elimination (<i>n</i> = 7) or severalfold reduction (<i>n</i> = 2) of the mutation in urine following tumor resection. Four of the seven patients with no detectable mutations in postoperative urine remained recurrence-free within five years after surgery. In contrast, all six patients with mutation-positive in post-operative urine recurred, including the two with reduced mutation levels. This is the first report of association between the presence of <i>CTNNB1</i> mutations in pre- and post-operative urine cfDNA and HCC recurrence with implications for minimum residual disease detection.