gebhart/patrepeval huggingface dataset:
Covalent linkage of heparin provides a stable anti‐coagulation surface of decellularized porcine arteries (2008)

Establishing thrombosis-resistant surface is crucial to develop tissue-engineered small diameter vascular grafts for arterial reconstructive procedures. The objective of this study was to evaluate the stability and anti-coagulation properties of heparin covalently linked to decellularized porcine carotid arteries. Cellular components of porcine carotid arteries were completely removed with chemical and physical means. Heparin was covalently linked to the decellularized vessels by a chemical reaction of the carboxyl end of amino acids with hydroxylamine sulphate salt and heparin-EDC. Bound heparin contents were measured by quantitative colorimetric assay of toluidine blue staining. The average content of heparin in treated vessels was 35.6 +/- 11.6 mg/cm(2) tissue, which represented 6.21 +/- 2.03 UPS heparin/cm(2) tissue. The stability of heparin linkage was tested by incubating the heparin-linked vessels either in PBS at 37 degrees C or in 70% alcohol at room temperature up to 21 days, showing no significant reduction of heparin content. Anti-coagulation property of bound heparin was determined with a clotting time assay using fresh dog blood. Standardized small pieces of non-heparin-bound vessels were clotted in fresh dog blood within 10 min., whereas all heparin-bound vessels did not form clot during 1-hr observation. In vivo platelet deposition of the vessel was determined with a baboon model of the femoral arteriovenous external shunt and (111)Indium labelling of platelets. There were 1.38 +/- 0.07 x 10(9) and 0.64 +/- 0.11 x 10(9) baboon platelets deposited on the control and heparin-linked vessels, respectively, at 60 min. These data demonstrate that covalent linkage of heparin provides an effective and stable anti-coagulation surface of decellularized porcine carotid arteries. This study may suggest a new strategy to develop tissue-engineered biological vascular grafts, which could be used for human coronary or low extremity artery bypasses.
Pipejacking & Microtunnelling (1993)

Covers development of trenchless technology; pipejacking and microtunnelling methods equipment: shields and tunnel boring machines; pipejacking: line, drive pit, top side; equipment: microtunnelling; design concepts.
StaR: Breaking the Scalability Limit for RDMA (2021)

Due to its superior performance, Remote Direct Memory Access (RDMA) has been widely deployed in data center networks. It provides applications with ultra-high throughput, ultra-low latency, and far lower CPU utilization than TCP/IP software network stack. However, the connection states that must be stored on the RDMA NIC (RNIC) and the small NIC memory result in poor scalability. The performance drops significantly when the RNIC needs to maintain a large number of concurrent connections.We propose StaR (Stateless RDMA), which solves the scalability problem of RDMA by transferring states to the other communication end. Leveraging the asymmetric communication pattern in data center applications, StaR lets the communication end with low concurrency save states for the other end with high concurrency, thus making the RNIC on the bottleneck side to be stateless. We have implemented StaR on an FPGA board with 10Gbps network port and evaluated its performance on a testbed with 9 machines all equipped with StaR NICs. The experimental results show that in high concurrency scenarios, the throughput of StaR can reach up to 4.13x and 1.35x of the original RNIC and the latest software-based solution, respectively.
Working together to improve the evidence base: abridged Cochrane reviews in<i>Sexually</i><i>Transmitted</i><i>Infections</i> (2018)

in touch with review authors. Help to make sure that the management of STIs
Una complessa chiarezza: gli ipertesti di Primo Levi (2016)

Scrittore poliedrico e versatile, Primo Levi è stato anche un costruttore di estesi e articolati ipertesti: strutture macrotestuali fondate su legami e interrelazioni tese fra opere cronologicamente e tipologicamente differenziate. Un esempio straordinario, ma non certo isolato, di questa scrittura di secondo grado, organizzata in complessi palinsesti testuali, è quello che già Marco Belpoliti ha definito nei termini di «macrotesto del Lager»: un reticolo intra- e intertestuale che, a partire da Se questo è un uomo, si è sviluppato con un andamento rizomatico attraverso diverse stratificazioni scrittorie e genealogiche, sino a I sommersi e i salvati. Il «rizoma» tuttavia è semplicemente una delle varie macrostrutture individuabili nell’opera di Levi. Attraverso un confronto contrastivo con l’opera di Calvino, il saggio si propone di indagare alcune delle caratteristiche salienti di questa scrittura ipertestuale, mostrando come l’intensa sperimentazione scrittoria perseguita da Levi sia da ricollegarsi a una parallela svolta epistemologica, data dall’insorgere di quella che Edgar Morin ha definito come «sfida della complessità». Primo Levi can be considered a versatile and polyhedral writer, capable of building long and articulated hypertexts, i.e., macrotextual structures based on the links and interrelations among works which differ both from a chronological and typological point of view. An extraordinary, but certainly not isolated, example of this writing, organized according to complex textual palimpsests, is the one that Marco Belpoliti defined as the «macrotext of the Lager»: it is an intra- and intertextual network that, starting from If This is a Man, developed according to a rhizomatic structure through his different works and genealogical stratifications, ending with The Drowned and the Saved. The «rhizome», however, is only one of the different macrostructures which may be singled out in Levi’s work. By developing a contrastive comparison with the work of Calvino, this essay aims to investigate some of the salient features of such hypertextual writing, thus showing how the marked textual experimentation pursued by Levi has to be linked to a parallel epistemological turn, given by the emergence of what Edgar Morin defined as the «challenge of complexity». PAROLE CHIAVE Primo Levi; Italo Calvino; ipertesto; rizoma; complessità.
Resolution of the nirD Locus for Heme d1, Synthesis of Cytochrome cd1, (Respiratory Nitrite Reductase) from Pseudomonas Stutzeri (1995)

The genetic organization of the nirD locus of Pseudomonas stutzeri ZoBell, necessary for a catalytically active cytochrome cd1 (EC 1.9.3.2), was determined. The locus comprises the unidirectionally transcribed open reading frames nirFDLGH, downstream of nirMC of the nir gene cluster, and immediately upstream of the norCB operon encoding nitric oxide (NO) reductase (EC 1.7.99.7). Notable sequence relatedness was found between NirF and cytochrome cd1 (NirS), within NirDLGH, and between NirM and NirC, suggesting several gene duplication events in this region. The derived NirF protein (391 amino acids, M(r) 43,137) has 23.8% identity (51.1% overall similarity) with NirS, but lacks the N-terminal heme-c-binding domain of NirS. Insertional mutagenesis of the five open reading frames resulted in the loss of respiratory nitrite reductase activity in vivo and in vitro. Mutant strains, when induced with nitrate for denitrification, synthesized a periplasmic cytochrome cd1 lacking heme d1. The defect was caused by the inability of the cell to synthesize heme d1. The nirD locus is proposed to encode a multimeric and multifunctional enzyme complex involved in the synthesis of heme d1. Mutations in nirFDLGH lowered substantially the expression level of norCB. Nir- mutants, unable to generate NO in vivo, provide indirect evidence for an NO sensor and an inducer role of NO for its cognate reductase.
Depletion of the Leukemic Fusion Protein MLL-AF4 with Short Interfering RNAs (siRNAs) Affects Post-Translational Modification of Aldolase A. (2005)

Abstract The chromosomal translocation t(4;11) marks a therapy-resistant infant leukemia with very poor prognosis. It results in the expression of two fusion-proteins, MLL-AF4 and AF4-MLL. We addressed the role of MLL-AF4 in t(4;11) positive SEM cells by siRNA-mediated suppression. Depletion of MLL-AF4 results in induction of apoptosis, inhibition of proliferation, decrease in colony formation and diminished leukemic engraftment in vivo. Currently, we are analyzing global changes in protein expression. For that, we compare the proteome of MLL-AF4 depleted SEM cells with those of control cells. The analysis is performed by 2D-gelelectrophoresis followed by mass spectrometry identification and immunoblot validation of differentially expressed spots. One of these spots was identified as Aldolase A. Comparison of MLL-AF4 depleted SEM cells with control cells showed neither change in mRNA levels nor in absolute protein levels of Aldolase A. Two-dimensional western blotting, however, revealed differences in the protein pattern, suggesting changes in Aldolase A modifications upon MLL-AF4 depletion. These analyses will provide us with a better insight into the effects of siRNA-mediated MLL-AF4 knockdown on the proteome, and may enable us to identify new targets for molecular therapeutic approaches.
SYNTEST: a method for high-level SYNthesis with self-TESTability (2002)

The article introduces a new high-level synthesis method for self-testable RTL designs. A basic feature of this method is a structural testability model which treats testability as a structural design style integrated in the design process. The main objective is to develop a system-level synthesis tool set mapping a behavioral description onto an optimized and testable RTL design subject to user-defined constraints. The approach involves several major components within the following system-level iteration: scheduling and allocation, constraint estimation, and testability tradeoffs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism (2011)

Viruses rely on the metabolic network of the host cell to provide energy and macromolecular precursors to fuel viral replication. Here we used mass spectrometry to examine the impact of two related herpesviruses, human cytomegalovirus (HCMV) and herpes simplex virus type-1 (HSV-1), on the metabolism of fibroblast and epithelial host cells. Each virus triggered strong metabolic changes that were conserved across different host cell types. The metabolic effects of the two viruses were, however, largely distinct. HCMV but not HSV-1 increased glycolytic flux. HCMV profoundly increased TCA compound levels and flow of two carbon units required for TCA cycle turning and fatty acid synthesis. HSV-1 increased anapleurotic influx to the TCA cycle through pyruvate carboxylase, feeding pyrimidine biosynthesis. Thus, these two related herpesviruses drive diverse host cells to execute distinct, virus-specific metabolic programs. Current drugs target nucleotide metabolism for treatment of both viruses. Although our results confirm that this is a robust target for HSV-1, therapeutic interventions at other points in metabolism might prove more effective for treatment of HCMV.
Fingerprint pattern recognition for medical uses-A frequency domain approach (2002)

A method of automatically classifying fingerprints into three groups, whorl, loop, and arch is described. It can help medical scientists to study the relationship between fingerprint patterns and medical disorders, such as breast cancer. In the research, a frequency domain approach that uses the feature of Fourier spectrum was developed; that is, prominent peaks in the spectrum give the principal direction of fingerprint patterns. Using the above feature, the authors obtain the principal direction of every subregion. The pattern of the whole image then can be determined. The frequency domain approach allows one to classify whorl faster and is less sensitive to the quality of fingerprint image, but it does not easily allow for the classification of arch and loop when triradii areas are too small.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cell and tissue specific expression of human Krüppel-like transcription factors in human ocular surface. (2004)

For the first time, we established the presence of a KLF network in the human ocular surface and illustrated the conservation of KLF4's biological properties in a corneal derived epithelial cell line.
Electrochemical Sensor for Detecting Ultratrace Nitroaromatic Compounds Using Mesoporous SiO<sub>2</sub>-Modified Electrode (2006)

An electrochemical sensor for ultratrace nitroaromatic compounds (NACs) using mesoporous SiO2 of MCM-41 as sensitive materials is reported. MCM-41 was synthesized and characterized by scanning electron microscope, transmission electron microscopy, and small-angle X-ray diffraction. Glassy carbon electrodes modified with MCM-41 show high sensitivity for cathodic voltammetric detection of NACs (including 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitrobenzene (TNB), 2,4-dinitrotoluene, and 1,3-dinitrobenzene) down to the nanomolar level. The high sensitivity is attributed to the strong adsorption of NACs by MCM-41 and large surface area of the working electrode resulting from MCM-41 modification. The voltammetric response is fast, and the detection of NACs can be finished within 14 s. SiO2 nanospheres were similarly used to modify glassy carbon electrodes for electrochemical detection of TNT and TNB. The detection limit of SiO2 nanosphere-modified electrodes is lower than that of MCM-41-modified electrodes, possibly due to the smaller surface area of SiO2 nanospheres than mesoporous MCM-41. The results show mesoporous SiO2-modified glassy carbon electrodes, particularly MCM-41-modified electrodes, open new opportunities for fast, simple, and sensitive field analysis of NACs.
Finite and infinite element analysis of coupled cylindrical microstrip line in a nonhomogeneous dielectric media (2002)

An effective method for computing the parameters of a coupled cylindrical microstrip line system is presented in this paper. Consider a cylindrical microstrip line cross-sectional configuration consisting of two concentric cylindrical dielectric substrates. Two arbitrary number C/sub 1/ and C/sub 2/ of infinitesimally thin arc strips of the arbitrary size (/spl alpha//sub 1//spl les/S/sub 1//spl les//spl beta//sub 1/) and (/spl alpha//sub 2//spl les/S/sub 2//spl les//spl beta//sub 2/) are clad on the dielectric cylindrical interfaces. The dielectric cylinders are characterized by real scalar permittivity /spl epsiv//sub i/ and permeability /spl mu//sub 0/ while the region outside of the dielectric cylinders is free space providing constitutive parameters /spl epsiv//sub 0/ and /spl mu//sub 0/, respectively. The two conductors are charged by V/sub 1/ and V/sub 2/ while the C/sub 0/ is grounded. The analysis is based on finite and infinite element methods and the quasi-static TEM mode approximation. The quasistatic TEM is essentially a low frequency model of a microstrip line that can be concerned with the existence of electric and magnetic fields separately. The microstrip line system is analyzed with both the ordinary finite to discretize the /spl Omega//sub i/ bounded region and global exterior infinite element to cover the /spl Omega//sub 0/ unbounded domain. The potential and field distribution in the cross section of the microstrip line are determined by minimizing the energy functional of the Laplace's equation using the variational principle. Then it can be used to calculate the Maxwellian capacitance or inductance matrix per unit length of the microstrip line. The parameters of the microstrip line can be determined in terms of the capacitance or inductance matrix. The equivalent circuit for the coupled microstrip lines is developed and its application to the solution of wave propagation modes is demonstrated. In this investigation, the accurate solution of characteristic impedance, effective dielectric constant, attenuation, coupling, propagation constant, and so on has been analyzed in terms of the capacitance matrix. These parameters are important in the design of microstrip lines, strip lines, and transmission lines.
Masitinib Combined with Standard Gemcitabine Chemotherapy: In Vitro and In Vivo Studies in Human Pancreatic Tumour Cell Lines and Ectopic Mouse Model (2010)

These data establish proof-of-concept that masitinib can sensitise gemcitabine-refractory pancreatic cancer cell lines and warrant further in vivo investigation. Indeed, such an effect has been recently observed in a phase 2 clinical study of patients with pancreatic cancer who received a masitinib/gemcitabine combination.
Effect of Aspirin and Vitamin E on Phase Separation in Calf Lens Homogenate (1987)

Vitamin E (d-alpha-tocopherol) and aspirin were evaluated for their effects on the phase separation temperature, Tc, of calf lens cytoplasm. Vitamin E and aspirin were added to nuclear homogenate and the change in Tc was measured. Aspirin had no measurable effect on Tc. Vitamin E lowered Tc at a rate of -22 degrees C M-1 l-1. The results suggest that the effects of aspirin on cataract are unrelated to phase separation and that vitamin E may act on the phase separation in precataractous lens cells.
Resurgence of Mumps in Korea (2015)

Routine vaccination against mumps has markedly reduced its incidence. However, the incidence of mumps continuously has increased since 2007. In 2013, a large mumps epidemic occurred in Korea, and this epidemic is still an ongoing problem. This epidemic occurred primarily in school settings and affected vaccinated adolescents, predominantly male students. The recent resurgence of mumps is caused by multiple factors: suboptimal effectiveness of the current mumps vaccines, use of the Rubini strain vaccine, waning immunity in the absence of natural boosting due to the marked reduction in the mumps incidence, genotype mismatch between the vaccine and circulating mumps virus strains, and environmental conditions that foster intense exposures. Containment of mumps outbreaks is challenging because the sensitivity of diagnostic tests is low among vaccinees and control measures are less efficient because of the inherent nature of the mumps virus. Despite the suboptimal vaccine effectiveness in outbreak settings, maintaining the high vaccine coverage is an important strategy to prevent mumps outbreaks, given that the routine use of mumps vaccines has substantially reduced the incidence of mumps and its complications as compared with that in the pre-vaccine era. In order to control the current mumps epidemic and prevent further outbreaks, we need to better understand the dynamics of mumps among vaccinated populations and the changing epidemiology in Korea. Concerted efforts should be made to systematically monitor the immunization status of the Korean population and to improve diagnosis efficiency. Furthermore, more effective mumps vaccines need to be developed in the future.
Implementation of a Vector-based Tracking Loop Receiver in a Pseudolite Navigation System (2010)

We propose a vector tracking loop (VTL) algorithm for an asynchronous pseudolite navigation system. It was implemented in a software receiver and experiments in an indoor navigation system were conducted. Test results show that the VTL successfully tracks signals against the near-far problem, one of the major limitations in pseudolite navigation systems, and could improve positioning availability by extending pseudolite navigation coverage.
MicroRNA binding sites in the coding region of mRNAs: Extending the repertoire of post‐transcriptional gene regulation (2014)

It is well established that microRNAs (miRNAs) induce mRNA degradation by binding to 3' untranslated regions (UTRs). The functionality of sites in the coding domain sequence (CDS), on the other hand, remains under discussion. Such sites have limited impact on target mRNA abundance and recent work suggests that miRNAs bind in the CDS to inhibit translation. What then could be the regulatory benefits of translation inhibition through CDS targeting compared to mRNA degradation following 3' UTR binding? We propose that these domain-dependent effects serve to diversify the functional repertoire of post-transcriptional gene expression control. Possible regulatory benefits may include tuning the time-scale and magnitude of post-transcriptional regulation, regulating protein abundance depending on or independently of the cellular state, and regulation of the protein abundance of alternative splice variants. Finally, we review emerging evidence that these ideas may generalize to RNA-binding proteins beyond miRNAs and Argonaute proteins.
MemCore: Computing-in-Flash Design for Deep Neural Network Acceleration (2022)

Neural Networks (NNs) have been widely employed in modern artificial intelligence (AI) systems due to their unprecedented capability in classification, recognition and detection. However, the massive data communication between memory and processing units has been proven to be the main challenge to improve the efficiency of NNs based hardware. Significant power and latency are demand for NNs inference. Advanced process and package can mitigate the memory wall problem at the expense of cost. Computing-in-memory (CIM) is potentially the most efficient solution to this problem. However, CIM is an non Vonneuman architecture and uses analog signal instead of logical one. Classic methodologies of design, process, reliability, precision and compiler are impractical. We have explored a CIM architecture using floating technology for computation, called MemCore. MemCore supports computing precision of over 8-bits, flexible mapping of multi-layer neural networks on single core, as well as multi-core architecture to expand computing capabilities. We have released the product WTM2101 and are verifying a new product for performance over 10 Tops. This paper is a overview introduction of MemCore architecture.
Chromium Adsorption by Three Yeast Strains Isolated from Sediments in Morocco (2013)

Abstract Biosorption is an effective method to remove heavy metals from wastewater. In this work, Biosorption of Cr(VI) has been investigated by live and dead cells of three yeasts species: Cyberlindnera fabianii, Wickerhamomyces anomalus and Candida tropicalis. Sorption experiments were conducted in aqueous solutions at various pH conditions. Cr(VI) adsorption was highly pH dependent and the results indicated that the most effective pH range was found to be between 2 and 4 for the three species. Adsorption isotherms were modeled with the Langmuir and Freundlich equations and isotherm constants were calculated. The adsorption capacity calculated from Langmuir isotherm was 18.9 mg, 28.14 mg and 29.1 mg Cr(VI) g−1 Cr(VI) g−1 for C. fabianii, W. anomalus and C. tropicalis, respectively. The results suggest that the three yeasts could be used as effective adsorbents for the removal of Cr(VI) ions from contaminated sites. Keywords: biosorptionchromiumisothermspHyeast biomass Acknowledgments The authors thankfully acknowledge the financial and scientific support of Microbial Biotechnology Laboratory, Faculty of Sciences and Technology and of Regional Center of Interface (CURI), SMBA University, Fez, Morocco.