gebhart/patrepeval huggingface dataset:
Mining system audit data (2001)

Intrusion detection is an essential component of computer security mechanisms. It requires accurate and efficient analysis of a large amount of system and network audit data. It can thus be an application area of data mining. There are several characteristics of audit data: abundant raw data, rich system and network semantics, and ever "streaming". Accordingly, when developing data mining approaches, we need to focus on: feature extraction and construction, customization of (general) algorithms according to semantic information, and optimization of execution efficiency of the output models. In this paper, we describe a data mining framework for mining audit data for intrusion detection models. We discuss its advantages and limitations, and outline the open research problems.
PAOA (2011)

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Aspartyl Protease-Mediated Cleavage of BAG6 Is Necessary for Autophagy and Fungal Resistance in Plants (2016)

The Bcl-2-associated athanogene (BAG) family is an evolutionarily conserved group of cochaperones that modulate numerous cellular processes. Previously we found that Arabidopsis thaliana BAG6 is required for basal immunity against the fungal phytopathogen Botrytis cinerea. However, the mechanisms by which BAG6 controls immunity are obscure. Here, we address this important question by determining the molecular mechanisms responsible for BAG6-mediated basal resistance. We show that Arabidopsis BAG6 is cleaved in vivo in a caspase-1-like-dependent manner and via a combination of pull-downs, mass spectrometry, yeast two-hybrid assays, and chemical genomics, we demonstrate that BAG6 interacts with a C2 GRAM domain protein (BAGP1) and an aspartyl protease (APCB1), both of which are required for BAG6 processing. Furthermore, fluorescence and transmission electron microscopy established that BAG6 cleavage triggers autophagy in the host that coincides with disease resistance. Targeted inactivation of BAGP1 or APCB1 results in the blocking of BAG6 processing and loss of resistance. Mutation of the cleavage site blocks cleavage and inhibits autophagy in plants; disease resistance is also compromised. Taken together, these results identify a mechanism that couples an aspartyl protease with a molecular cochaperone to trigger autophagy and plant defense, providing a key link between fungal recognition and the induction of cell death and resistance.
Self‐Healing EBC Material for Gas Turbine Applications (2017)

This chapter examines Ytterbium bulk mono-silicate with dispersed silicon carbide particles as a novel material concept of self-healing EBCs for non-oxide ceramic matrix composites. The ability of crack healing of the composite was analyzed during furnace oxidation and burner rig tests on pre-cracked samples with 5 and 10 vol-% SiC. Superior crack-healing effects were observed in case of the 10 vol-% SiC containing material especially after oxidation tests at 1200°C and 1400°C. A drastic increase of strength was measured on the pre-cracked samples with 10 vol-% SiC after oxidation in comparison to the samples after fabrication. The mechanism of crack healing was identified as a microstructural transformation as the consequence of SiC oxidation and subsequent reaction of the oxidation product SiO2 with the ytterbium silicate.
3D range data compression with a virtual fringe projection system (2015)

This paper presents our recent research on 3D range data compression using the virtual fringe projection techniques. Specifically, the virtual fringe projection system converts arbitrary 3D object into one single red, green, and blue (RGB) color image that can be further compressed using standard image compression techniques. Since the virtual fringe projection system can be ideal (e.g., no ambient lighting, no surface reflectivity variations, perfect tele-centric lens), making it convenient to apply algorithms that is difficult to be realized in a practical fringe projection system. For example, only using three fringe patterns, pixel by pixel absolute phase can be calculated without adopting a global fringe analysis techniques (e.g., Fourier transform). We will demonstrate that extremely high compression ratios can be easily achieved with the proposed method.
Shoulder pain in people with a stroke: a population-based study (2003)

Shoulder pain after stroke is common, especially in patients with severe sensorimotor deficits, diabetics and those living at home. Appropriate management may reduce the rate of occurrence.
Distance-field based skeletons for virtual navigation (2001)

We present a generic method for rapid flight planning, virtual navigation and effective camera control in a volumetric environment. Directly derived from an accurate distance from boundary (DFB) field, our automatic path planning algorithm rapidly generates centered flight paths, a skeleton, in the navigable region of the virtual environment. Based on precomputed flight paths and the DFB field, our dual-mode physically based camera control model supports a smooth, safe, and sticking-free virtual navigation with six degrees of freedom. By using these techniques, combined with accelerated volume rendering, we have successfully developed a real-time virtual colonoscopy system on low-cost PCs and confirmed the high speed, high accuracy and robustness of our techniques on more than 40 patient datasets.
Transmission routes of Covid-19 virus in the Diamond Princess Cruise ship (2020)

Abstract Background An outbreak of COVID-19 occurred on the Diamond Princess cruise ship in January and February 2020. We analysed information about cases to infer transmission dynamics and potential modes of transmission. Methods We collected the daily number of 197 symptomatic cases, and that of the 146 passenger cases in two categories, i.e. those who stayed and did not stay in the same stateroom. We retrieved the quarantine details and the ship’s 14-day itinerary. We searched the websites of national/local health authority along the cruise routes and local news using Google for locally confirmed cases associated with the ship. We obtained the design of air conditioning and sewage treatment of the ship from literature. We back-calculated the dates of infection from the epidemic curve and compared with the start of on-board quarantine. Results Major infections started on Jan 28 and completed by Feb 6 for passengers except those who stayed in the same stateroom with infected individual(s). No other confirmed cases were identified among the disembarked people in Hong Kong except an 80 years old passenger. No confirmed cases were reported in three other stopovers between Jan 27-31 associated with disembarked passengers or visitors from the ship, however two Okinawa taxi drivers became confirmed cases in association with driving the ship passengers. Infection among passengers after Feb 6 was limited to those who stayed in the same stateroom with an infected passenger. Infections in crew members peaked on Feb 7, suggesting significant transmission among crew members after quarantine on Feb 5. Conclusions We infer that the ship central air conditioning system did not play a role, i.e. the long-range airborne route was absent in the outbreak. Most transmission appears to have occurred through close contact and fomites. Significance Statement Transmission by the long-range airborne route for SARS-CoV-2 in the 2020 Diamond Princess Covid-19 outbreak has been debated with significant implication for intervention. We found that the transmission by close contact and fomite explains the outbreak, and the central air-conditioning system did not play a role, demonstrating the importance of social distancing, good hygiene and maintaining good building ventilation for intervention.
Constant-frequency current slope control for single-phase switch-mode rectifiers without current sensors (2002)

In this paper, we present a novel control scheme for single-phase boost-type switch-mode rectifiers (SMRs). Based on the input current slopes, which depend on the source voltage, output DC level and boost inductance, the duty ratios of the switches are determined to achieve a unity power factor. No current sensors are required. By utilizing the triangular PWM comparators, the proposed control scheme can be fulfilled with a constant switching frequency. This novel control method with low costs and simple circuitry can be applied to any boost-type SMR. Simulations and experiments are performed. The results show feasibility of the presented scheme.
The use of a human papillomavirus 18 promoter for tissue-specific expression in cervical carcinoma cells (2011)

The use of tissue-specific promoter elements in the treatment of cervical cancer has been explored in this paper. The P(105) promoter of human papillomavirus 18 (HPV18) was utilised to direct tissue-specific expression in a number of cell types. Expression was examined in three cervical carcinoma cell lines: HeLa (HPV18 positive), SiHa (HPV16 positive), and C33A cells (HPV negative); the epithelial cell line, H1299; and the foetal fibroblast cell line, MRC5, utilising a luciferase expression vector. Expression was highest in the cervical cell lines by a factor of at least 80. The effect of a number of mutations in the P(105) promoter on expression levels was examined. Three deletion constructs of the long control region (LCR) were investigated: an 800 bp fragment (LCR800), a 400 bp fragment (LCR400), and a 200 bp fragment (LCR200), as well as the full length product LCR of HPV18 (LCR1000). The LCR800 construct of the HPV18 P(105) promoter had the highest level of expression in the cervical cell lines and was also highest in the HPV18-positive HeLa cell line. Site-directed mutagenesis was then employed on the LCR800 construct to create four further constructs that each had inactivating mutations in one of the four E2 binding sites (E2BSs). Overall, this study indicated that the LCR800 construct of the HPV18 P(105) promoter could be utilised as a tissuerestricted promoter in cervical cancer cells.
Extracorporeal membrane oxygenation, an anesthesiologist′s perspective: Physiology and principles. Part 1 (2011)

Extracorporeal membrane oxygenation (ECMO) is an adaptation of conventional cardiopulmonary bypass techniques to provide cardiopulmonary support. ECMO provides physiologic cardiopulmonary support to aid reversible aspects of the disease process and to allow recovery. ECMO does not provide treatment of the underlying disease. The indications for ECMO support have expanded from acute respiratory failure to acute cardiac failure refractory to conventional treatments from wide patient subsets involving neonates to adults. Vascular access for ECMO support is either percutaneous through a single-site, dual-lumen bicaval cannula or transthoracic via separate cannulas. The modes of support are either veno-venous or veno-arterial ECMO. In this article, the physiologic aspects of ECMO support are outlined.
Performance of Adaptive Sleep Period Control for Wireless Communications Systems (2006)

Sleep mode operation is widely used in wireless communications systems to reduce power consumption of portable devices. The optimal length of sleep period is affected by the message interarrival time that varies over time. In this letter, the adaptive schemes to control sleep period is investigated. We first generalize the scheme in 2004 and then suggest another variant of the generalized scheme, where the sleep period increases or decreases exponentially depending on whether a message arrives or not. The performance of these two schemes is evaluated by using Markov analysis. Numerical results show that the schemes operate effectively when the system is lightly loaded, which is the operating environment of sleep mode in practice
New decision-based trimmed median filter for high-density salt-and-pepper noise removal in images (2014)

A new switching-based trimmed median filter to remove high-density salt-and-pepper noise in digital images is proposed. Initially, a 3×3 sliding window is applied on each pixel in the noisy image. The minimum- and maximum-intensity values are trimmed, and the noisy pixels are detected based on the predefined threshold value. In the filtering stage, the noisy pixels are replaced by median value of uncorrupted pixels in the trimmed array. At very high noise density, if all the pixels in the sliding window are corrupted, then the proposed algorithm replaces noisy pixels by the midpoint of recently processed pixels. The experimental results for various test images show that the performance of the proposed algorithm is superior to the existing algorithms, namely SMF, WMF, CWMF, AMF, DBA, and MDBUTMF in terms of visual quality and edge preservation, even at noise levels as high as 95%.
Detrusor myectomy: long‐term results with a minimum follow‐up of 2 years (2005)

Detrusor myectomy is successful in approximately 80% of patients with idiopathic DO, although detrusor contractility is affected in most and almost half of the patients required clean intermittent self-catheterization afterward. This procedure should be offered as an alternative to enterocystoplasty as it is less morbid and does not preclude subsequent surgery if required. However, further evaluation of this technique is required in neuropathic patients.
Natural human-robot interaction using speech, head pose and gestures (2005)

In this paper we present our ongoing work in building technologies for natural multimodal human-robot interaction. We present our systems for spontaneous speech recognition, multimodal dialogue processing and visual perception of a user, which includes the recognition of pointing gestures as well as the recognition of a person's head orientation. Each of the components is described in the paper and experimental results are presented. In order to demonstrate and measure the usefulness of such technologies for human-robot interaction, all components have been integrated on a mobile robot platform and have been used for real-time human-robot interaction in a kitchen scenario.
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking (2004)

14-3-3-interacting proteins were isolated from extracts of proliferating HeLa cells using 14-3-3 affinity chromatography, eluting with a phosphopeptide that competes with targets for 14-3-3 binding. The isolated proteins did not bind to 14-3-3 proteins (14-3-3s) after dephosphorylation with protein phosphatase 2A (PP2A), indicating that binding to 14-3-3s requires their phosphorylation. The binding proteins identified by tryptic mass fingerprinting and Western blotting include many enzymes involved in generating precursors such as purines (AMP, GMP and ATP), FAD, NADPH, cysteine and S-adenosylmethionine, which are needed for cell growth, regulators of cell proliferation, including enzymes of DNA replication, proteins of anti-oxidative metabolism, regulators of actin dynamics and cellular trafficking, and proteins whose deregulation has been implicated in cancers, diabetes, Parkinsonism and other neurological diseases. Several proteins bound to 14-3-3–Sepharose in extracts of proliferating cells, but not in non-proliferating, serum-starved cells, including a novel microtubule-interacting protein ELP95 (EMAP-like protein of 95 kDa) and a small HVA22/Yop1p-related protein. In contrast, the interactions of 14-3-3s with the N-methyl-d-aspartate receptor 2A subunit and NuMA (nuclear mitotic apparatus protein) were not regulated by serum. Overall, our findings suggest that 14-3-3s may be central to integrating the regulation of biosynthetic metabolism, cell proliferation, survival, and other processes in human cells.
Switchable Holograms for Automotive Applications (1997)

<div class="htmlview paragraph">This paper will discuss the relatively new technology of polymer dispersed liquid crystal (PDLC) based switchable holograms and its potential for application in the automotive industry. We have developed a novel photopolymer dispersed liquid crystal based material system, which allows fast, single-step recording of holograms with electrically controllable diffraction efficiency. The various characteristics of the holograms will be described as well as special considerations for various potential device configurations. Material characteristics to be described include transmission efficiency, diffraction efficiency, switching dynamic range, switching speed, recording sensitivity, temperature effects, voltage requirements, and system stability. Device applications to be considered include holographic optical elements, fiber switching, and displays.</div>
Modular information hiding and type-safe linking for C (2007)

This paper presents CMod, a novel tool that provides a sound module system for C. CMod works by enforcing a set of four rules that are based on principles of modular reasoning and on current programming practice. CMod's rules flesh out the convention that .h header files are module interfaces and .c source files are module implementations. Although this convention is well-known, developing CMod's rules revealed there are many subtleties in applying the basic pattern correctly. We have proven formally that CMod's rules enforce both information hiding and type-safe linking. We evaluated CMod on a number of benchmarks, and found that most programs obey CMod's rules, or can be made to with minimal effort, while rule violations reveal brittle coding practices including numerous information hiding violations and occasional type errors.
Role of Inflammation in Polycystic Kidney Disease (2015)

Polycystic kidney disease (PKD) is a genetic disorder that is characterized by progressive growth of multiple cysts in the kidneys. Two forms of the disease exist, autosomal dominant PKD (ADPKD) and autosomal recessive PKD (ARPKD). ADPKD is the most common form of genetic disorder of the kidney. In the United States about 600,000 people have PKD. This disease eventually leads to end stage kidney disease (ESKD) which may take as long as three decades to develop and requires renal replacement therapy. PKD is the fourth largest cause of kidney failure. Interstitial inflammation is a common component of chronic kidney disease (CKD) and, it is a better prognostic marker, than glomerular health, for progression of the disease or kidney function. PKD is no exception. Markers of inflammation are present much earlier than detectable cyst growth and correlate with the disease progression. While in other kidney diseases interstitial inflammation is mostly associated with interstitial fibrosis, in PKD inflammation is also linked to cyst progression. Inflammatory cells such as macrophages have been reported in both human and experimental animal models of PKD, with the degree of macrophage infiltrate associated with disease progression in humans. In animal models of PKD, macrophages have been associated with cyst growth and deteriorating renal function. What may differentiate PKD from the rest of the CKD is that experimental evidence suggests a direct role of PKD genes in regulating expression of some of the pro-inflammatory chemoattractants such as monocyte chemoattractant protein-1 (MCP-1) and other cytokines. Indeed, increased urinary levels of MCP-1 correlate with the progression of disease in humans. This chapter will highlight some of the work that provides evidence for the role of inflammation in disease progression in PKD.
Vitamin D analogs: new therapeutic agents for the treatment of squamous cancer and its associated hypercalcemia. (1995)

We have examined the in vitro effects of 1,25 dihydroxy-vitamin D3 [1,25(OH)2D3] and of two side-chain modified analogs of 1,25(OH)2D3 (EB1089 and MC903) on cell growth and parathyroid hormone related peptide (PTHRP) production in immortalized (HPK1A) and neoplastic (HPK1A-ras) keratinocytes. Cell proliferation was strongly inhibited by 1,25(OH)2D3 and its analogs in HPK1A cells, and in this system EB1089 was 10-100 times more potent than 1,25(OH)2D3 or MC903. A similar effect on cell proliferation was observed in HPK1A-ras cells; however, 10-fold higher concentrations of 1,25(OH)2D3 or its analogs were required. We also observed a strong and dose-dependent inhibitory effect of these compounds on PTHRP secretion and gene expression. In both immortalized and neoplastic keratinocytes, EB1089 was 10-100 times more potent than 1,25(OH)2D3 or MC903 on inhibiting PTHRP production. However, although effective in HPK1A-ras cells, 10-fold higher concentrations of 1,25(OH)2D3 or its analogs were required to produce similar actions in this neoplastic model. These studies therefore demonstrate that a 1,25(OH)2D3 analog with low calcemic potency in vivo (EB1089) can inhibit keratinocyte proliferation and PTHRP production by such cells with greater potency than 1,25(OH)2D3. The observed effects of such analogs in neoplastic keratinocytes predicts their potential usefulness in vivo in inhibiting squamous cancer growth and its associated hypercalcemia.
Distortion Center Estimation using FOV Model and 2D Pattern (2013)

본 논문은 넓은 시야각을 갖는 어안렌즈로 촬영 시, 발생하는 방사 왜곡을 보정하는데 있어 왜곡의 중심을 추정하는 방법을 제안한다. FOV 왜곡 보정 모델의 경우 렌즈의 왜곡중심을 별도로 추정하지 않기 때문에 영상의 중심점과 렌즈의 왜곡중심의 오차가 클수록 왜곡보정의 정확도가 떨어지는 단점이 있다. 이에 본 논문은 광각 렌즈에서 FOV 모델과 2D 패턴을 이용하여 렌즈의 왜곡중심 추정을 통해 보다 정밀한 왜곡 보정 방법을 제안한다. 이를 위해 FOV 모델로부터 발생하는 왜곡곡선을 직선과 비교하여 곡선과 직선의 차가 가장 적은 위치를 왜곡의 중심으로 설정한다. 이 방법을 통하여 렌즈와 센서 중심점의 오차에 의해 발생하는 왜곡 중심 추정의 정확도를 향상시킬 수 있었고 실험결과를 통하여 확인할 수 있었다. This paper presents a simple method to estimate center of distortion and correct radial distortion from fish-eye lens. If the center of image is not locate that of lens in a straight line, the disadvantage of FOV model is low accurate because of correcting distortion without estimated centre of distortion. We propose a method accurately estimating Distortion center using FOV model and 2D pattern from wide angle lens. Our method determines the center of distortion in least error between straight lines and curves with FOV model. The results of experimental measurements on synthetic and real data are presented.
Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies (2010)

In seven patients with type B insulin resistance, standardized treatment with rituximab, cyclophosphamide, and pulse steroids results in remission of the disease. Future studies will determine whether this treatment protocol can be applied to other autoantibody/cell surface receptor disease states.
Functional Characterization of Aquaporin-4 Specific T Cells: Towards a Model for Neuromyelitis Optica (2011)

Background: Antibodies to the water channel protein aquaporin-4 (AQP4), which is expressed in astrocytic endfeet at the blood brain barrier, have been identified in the serum of Neuromyelitis optica (NMO) patients and are believed to induce damage to astrocytes. However, AQP4 specific T helper cell responses that are required for the generation of anti-AQP4 antibodies and most likely also for the formation of intraparenchymal CNS lesions have not been characterized.
Facile fabrication of a superhydrophilic–superhydrophobic patterned surface by inkjet printing a sacrificial layer on a superhydrophilic surface (2016)

A superhydrophilic–superhydrophobic patterned surface was facilely fabricated by controlling the depositing morphology of the inkjet droplet on a superhydrophilic surface.