gebhart/patrepeval huggingface dataset:
Integration of Piezoceramic Tube under Prestress into a Load Carrying Structure (2014)

Smart structures consisting of a load carrying structure and smart materials with actuatory and sensory capabilities feature high potential in numerous applications. However, to master the assembly conditions of smart structures, there is a need to integrate additional design parameters such as prestress of the smart material, critical loads and electric contacting as well as insulation into the process development. This paper focusses on the design of an incremental bulk forming process to integrate piezoceramic components into an aluminum tube simultaneously to the manufacturing process. Axial forces imposed on the piezoceramic are investigated numerically and experimentally to verify the design of critical components and the process control. Within this investigation, in situ measurement of the direct piezoelectric effect provides a method to validate the numerical design with regard to failure of the piezo tube and the functional properties of the overall structure.
42/spl times/42.7 Gb/s RZ-DPSK transmission over a 4820 km long NZDSF deployed line using C-band-only EDFAs (2004)

The transmission of 42 RZ-DPSK channels at 42.7 Gb/s is demonstrated over 4820 km of NZDSF deployed line with more than 3 dB margin. A performance comparison with the same capacity using 166/spl times/10 Gb/s DPSK is demonstrated.
Phase Stability in Calcia‐Doped Zirconia Nanocrystals (2016)

Calcia‐doped zirconia exhibits all of the polymorphism seen in the yttria‐doped zirconia ceramics, but can be produced at lowered costs and in greater abundance due to the accessibility of Calcium precursors in comparison to Yttrium. Although with great challenges, there exists an opportunity to replace yttria with calcia in applications such as ionic conductors where phase stability is critical. There is a dearth of surface characterization to enable design and prediction of the polymorphism in nanoparticulate calcia–zirconia. With recent advances in water adsorption microcalorimetry, one can accurately probe surface energies of the four zirconia polymorphs: monoclinic, tetragonal, cubic, and amorphous. The surface energies can then be coupled with bulk enthalpies extracted from oxide melt drop solution calorimetry to create a nanocrystalline phase stability diagram similar to its bulk counterpart. We report here the surface and bulk thermodynamic data on polymorphs of calcia–zirconia with composition ranging from 0 to 20 mol% calcia and use it to build a nanophase diagram for this system. The effect of the humidity in the phase stability diagram trends is also addressed and demonstrated to minimize the effect of the surface energies in the overall polymorphism trends.
The origins and biological significance of the coccidial lesions that occur in chickens vaccinated with a live attenuated anticoccidial vaccine (2001)

The occurrence of vaccine-induced coccidial lesions in chicks vaccinated with a live attenuated anticoccidial vaccine is demonstrated. Healthy broiler chicks reared on litter to facilitate autoreinfection, but isolated from extraneous coccidial infections, were vaccinated when 8 days old with Paracox. Coccidial lesions were found in chicks between 5 and 23 days after vaccination; 24% of the 87 chicks sampled during 29 days had intestinal lesions of Eimeria acervulina, Eimeria maxima, Eimeria tenella or of undetermined species, mostly (19 out of 21) scored as 1 or 2 on the Johnson & Reid scale of 0 to 4. The other two positive birds had E. tenella lesions, each scored as 3. The lesions observed up to 5 days after vaccination were identified as primary (i.e. a host response to the first vaccinal life cycle) and those observed from 6 days onwards were designated as primary or secondary (i.e. a host response to the second and subsequent vaccinal life cycles) in origin. In the absence of extraneous coccidial infections, none of the lesions observed could have been due to non-vaccinal coccidial infections. No adverse effects on the health or growth rate of the chicks exhibiting primary or secondary lesions in response to vaccination with Paracox were apparent.
Development of Ultra-Low Pt Alloy Cathode Catalyst for PEM Fuel Cells (2011)

Two approaches are described for the synthesis of ultra-low platinum loading catalysts for polymer electrolyte membrane fuel cell (PEMFC). The first approach is the synthesis of a hybrid cathode catalyst (HCC) which combines a non-platinum carbon based composite catalyst (CCC) with active catalytic sites for oxygen reduction reaction (ORR) as a support and highly active Pt/Pt-alloy catalysts. The activity of HCC is found to be 1.3 times higher than that of Pt/C in the platinum loading range of 0.1-0.4 mg cm-2, while it is 2.6 times that of Pt/C at platinum loading of 0.04 mg cm-2. The goal of our second strategy is the development of activated graphitic carbon (AGC) supported Pt3M1 (M=non-precious transition metal) catalyst (Pt3M1/AGC). The Pt3M1/AGC catalyst showed mass activity of 0.41 A mgPt-1 and specific activity of 1023 µA/cm2 at 0.9 ViR-free. Fuel cell performance evaluation under H2/air exhibited a high current density performance of 1.45 A at 0.56 ViR-free.
OMS302 (phenylephrine and ketorolac injection) 1%/0.3% to maintain intraoperative pupil size and to prevent postoperative ocular pain in cataract surgery with intraocular lens replacement (2015)

Cataract surgery with intraocular lens replacement is among the most commonly performed surgical procedures worldwide. Various pharmacologic agents are administered topically before and/or after, and a few are delivered intracamerally during, surgery to achieve mydriasis and to treat postoperative pain and inflammation. OMS302 (Omidria™ [phenylephrine and ketorolac injection] 1%/0.3%), a proprietary drug containing phenylephrine and ketorolac, was developed for use during cataract surgery to maintain intraoperative pupil size by preventing miosis and reduce early postoperative ocular pain. Containing no preservatives or bisulfites, OMS302 is formulated in a single-dose, single-patient use vial. Added to a standard 500 ml container of irrigation solution used during the procedure, OMS302 is infused into the anterior chamber with direct action on the iris and other ocular tissues. As the only US FDA-approved drug that is indicated both to prevent miosis and reduce postoperative pain associated with cataract surgery, OMS302 provides a new treatment option for ophthalmic surgeons.
Diagnosis of Plasmodium falciparum infections in mummies using the rapid manual ParaSight™-F test (1994)

Journal Article Diagnosis of Plasmodium falciparum infections in mummies using the rapid manual ParaSight™-F test Get access R.L. Miller, R.L. Miller 1The Bioanthropology Foundation Paleoepidemiology Project, 594 Main Street, Northport, NY 11768, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Ikram, S. Ikram 2Christ's College, Cambridge, CB2 3BU, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar G.J. Armelagos, G.J. Armelagos 3Department of Anthropology, Emory University, Atlanta, GA 30322, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Walker, R. Walker 4The Bioanthropology Foundation, Centre de Recherches, Sur-les-Planches, CH-2523 Lignières, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar W.B. Harer, W.B. Harer 5Office of the Secretary, The American College of Obstetricians and Gynecologists, 399 East Highland Avenue, Suite 517, San Bernardino, CA 92404, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar C.J. Shiff, C.J. Shiff 6Department of Immunology and Infectious Diseases, School of Hygiene and Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Baggett, D. Baggett 7Becton Dickinson Advanced Diagnostics, 1400 Coppermine Terrace, Baltimore, MD 21209-2012, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Carrigan, M. Carrigan 7Becton Dickinson Advanced Diagnostics, 1400 Coppermine Terrace, Baltimore, MD 21209-2012, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar S.M. Maret S.M. Maret 7Becton Dickinson Advanced Diagnostics, 1400 Coppermine Terrace, Baltimore, MD 21209-2012, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 88, Issue 1, January-February 1994, Pages 31–32, https://doi.org/10.1016/0035-9203(94)90484-7 Published: 01 January 1994 Article history Received: 26 October 1993 Accepted: 04 November 1993 Published: 01 January 1994
Association of the Golgi UDP-Galactose Transporter with UDP-Galactose:Ceramide Galactosyltransferase Allows UDP-Galactose Import in the Endoplasmic Reticulum (2003)

UDP-galactose reaches the Golgi lumen through the UDP-galactose transporter (UGT) and is used for the galactosylation of proteins and lipids. Ceramides and diglycerides are galactosylated within the endoplasmic reticulum by the UDP-galactose:ceramide galactosyltransferase. It is not known how UDP-galactose is transported from the cytosol into the endoplasmic reticulum. We transfected ceramide galactosyltransferase cDNA into CHOlec8 cells, which have a defective UGT and no endogenous ceramide galactosyltransferase. Cotransfection with the human UGT1 greatly stimulated synthesis of lactosylceramide in the Golgi and of galactosylceramide in the endoplasmic reticulum. UDP-galactose was directly imported into the endoplasmic reticulum because transfection with UGT significantly enhanced synthesis of galactosylceramide in endoplasmic reticulum membranes. Subcellular fractionation and double label immunofluorescence microscopy showed that a sizeable fraction of ectopically expressed UGT and ceramide galactosyltransferase resided in the endoplasmic reticulum of CHOlec8 cells. The same was observed when UGT was expressed in human intestinal cells that have an endogenous ceramide galactosyltransferase. In contrast, in CHOlec8 singly transfected with UGT 1, the transporter localized exclusively to the Golgi complex. UGT and ceramide galactosyltransferase were entirely detergent soluble and form a complex because they could be coimmunoprecipitated. We conclude that the ceramide galactosyltransferase ensures a supply of UDP-galactose in the endoplasmic reticulum lumen by retaining UGT in a molecular complex.
Composition and Bioactivities of the Leaf Essential Oils of<i>Cinnamomum subavenium</i>Miq. from Taiwan (2008)

Abstract Leaves of Cinnamomum subavenium Miq. were collected from two sites in Taiwan. Leaf essential oils of C. sub-avenium were isolated using hydrodistillation and headspace-GC methods to determine their composition and yield. Antioxidant and antimicrobial activities of various oils obtained were also evaluated. Forty-four and 88 compounds were identified in the leaf oils obtained. Whereas 26 and 65 compounds were identified by headspace-GC method, respectively. The main headspace components were comparable to those of the oil. The main components of one of the oils were methyl eugenol (75.9%), linalool (7.3%), and eugenol (6.6%); while those from the other oil were p-cymene (21.6%), 1,8-cineole (16.5%), and linalool (11.9%). Both leaf oils had excellent antioxidant and antimicrobial activities.
Biochemical and Genetic Characterization of <i>trans</i> -2′-Carboxybenzalpyruvate Hydratase-Aldolase from a Phenanthrene-Degrading <i>Nocardioides</i> Strain (1998)

trans-2'-Carboxybenzalpyruvate hydratase-aldolase was purified from a phenanthrene-degrading bacterium, Nocardioides sp. strain KP7, and characterized. The purified enzyme was found to have molecular masses of 38 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and 113 kDa by gel filtration chromatography. Thus, the homotrimer of the 38-kDa subunit constituted an active enzyme. The Km and kcat values of this enzyme for trans-2'-carboxybenzalpyruvate were 50 microM and 13 s(-1), respectively. trans-2'-Carboxybenzalpyruvate was transformed to 2-carboxybenzaldehyde and pyruvate by the action of this enzyme. The structural gene for this enzyme was cloned and sequenced; the length of this gene was 996 bp. The deduced amino acid sequence of this enzyme exhibited homology to those of trans-2'-hydroxybenzalpyruvate hydratase-aldolases from Pseudomonas putida PpG7 and Pseudomonas sp. strain C18.
Selective Deprotection of Silyl Ethers (1996)

This review focuses on the selective deprotection of silyl ethers in the presence of other like or unlike silyl ethers. Various examples are highlighted throughout the text, and these examples are compiled in tabular form at the end of the document (Tables 16-27). The abbreviations and structures for some of the more common silyl groups are given in Figure 1.
RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells (2014)

Development and function of pancreatic β cells involve the regulated activity of specific transcription factors. RFX6 is a transcription factor essential for mouse β cell differentiation that is mutated in monogenic forms of neonatal diabetes. However, the expression and functional roles of RFX6 in human β cells, especially in pathophysiological conditions, are poorly explored. We demonstrate the presence of RFX6 in adult human pancreatic endocrine cells. Using the recently developed human β cell line EndoC-βH2, we show that RFX6 regulates insulin gene transcription, insulin content, and secretion. Knockdown of RFX6 causes downregulation of Ca(2+)-channel genes resulting in the reduction in L-type Ca(2+)-channel activity that leads to suppression of depolarization-evoked insulin exocytosis. We also describe a previously unreported homozygous missense RFX6 mutation (p.V506G) that is associated with neonatal diabetes, which lacks the capacity to activate the insulin promoter and to increase Ca(2+)-channel expression. Our data therefore provide insights for understanding certain forms of neonatal diabetes.
Domain estimation under informative linkage (2019)

A standard assumption when modelling linked sample data is that the stochastic properties of\nthe linking process and process underpinning the population values of the response variable\nare independent of one another. This is often referred to as non-informative linkage. But what\nif linkage errors are informative? In this paper, we provide results from two simulation experiments\nthat explore two potential informative linking scenarios. The first is where the choice of\nsample record to link is dependent on the response; and the second is where the probability of\ncorrect linkage is dependent on the response. We focus on the important and widely applicable\nproblem of estimation of domain means given linked data, and provide empirical evidence that\nwhile standard domain estimation methods can be substantially biased in the presence of informative\nlinkage errors, an alternative estimation method, based on a Gaussian approximation to\na maximum likelihood estimator that allows for non-informative linkage error, performs well.
DNA Sequencing on Microfabricated Electrophoretic Devices (1998)

We present a model that quantitatively describes the performance of microfabricated electrophoretic devices filled with linear polyacrylamide as replaceable sieving material for single-stranded DNA analyses. The dependence of resolution on various separation parameters such as selectivity, diffusion, injector size, device length, and channel folding was investigated. A previously predicted dependence of longitudinal diffusion coefficient on electric field strength has been verified. We have used this model to develop and optimize microfabricated electrophoretic devices for DNA analyses. For single-color DNA sequencing mixtures, we routinely achieve separations of 400 bases in under 14 min at 200 V/cm, and separation of 350 bases in only 7 min at 400 V/cm, with a minimum resolution of R = 0.5. Our results also indicate reduced fragment biasing and efficient sample stacking for DNA sample loading on microfabricated devices.
The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle (1998)

In skeletal muscle, overall protein degradation involves the ubiquitin-proteasome system. One property of a protein that leads to rapid ubiquitin-dependent degradation is the presence of a basic, acidic, or bulky hydrophobic residue at its N terminus. However, in normal cells, substrates for this N-end rule pathway, which involves ubiquitin carrier protein (E2) E214k and ubiquitin-protein ligase (E3) E3alpha, have remained unclear. Surprisingly, in soluble extracts of rabbit muscle, we found that competitive inhibitors of E3alpha markedly inhibited the 125I-ubiquitin conjugation and ATP-dependent degradation of endogenous proteins. These inhibitors appear to selectively inhibit E3alpha, since they blocked degradation of 125I-lysozyme, a model N-end rule substrate, but did not affect the degradation of proteins whose ubiquitination involved other E3s. The addition of several E2s or E3alpha to the muscle extracts stimulated overall proteolysis and ubiquitination, but only the stimulation by E3alpha or E214k was sensitive to these inhibitors. A similar general inhibition of ubiquitin conjugation to endogenous proteins was observed with a dominant negative inhibitor of E214k. Certain substrates of the N-end rule pathway are degraded after their tRNA-dependent arginylation. We found that adding RNase A to muscle extracts reduced the ATP-dependent proteolysis of endogenous proteins, and supplying tRNA partially restored this process. Finally, although in muscle extracts the N-end rule pathway catalyzes most ubiquitin conjugation, it makes only a minor contribution to overall protein ubiquitination in HeLa cell extracts.
Bioinspired Bioadhesive Polymers: Dopa‐Modified Poly(acrylic acid) Derivatives (2012)

The one-step synthesis and characterization of novel bioinspired bioadhesive polymers that contain Dopa, implicated in the extremely adhesive byssal fibers of certain gastropods, is reported. The novel polymers consist of combinations of either of two polyanhydride backbones and one of three amino acids, phenylalanine, tyrosine, or Dopa, grafted as side chains. Dopa-grafted hydrophobic backbone polymers exhibit as much as 2.5 × the fracture strength and 2.8 × the tensile work of bioadhesion of a commercially available poly(acrylic acid) derivative as tested on live, excised, rat intestinal tissue.
North  American Late Devonian Cephalopod Aptychi (1991)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Spread Spectrum system analysis, development, and testing, in a multipath UHF radio environment (1989)

Direct Sequence Spread Spectrum systems presently find use in navigation and military communication systems. In recent years, however, interest has also been shown in the potential of such systems for Land Mobile Radio applications. In particular the broadband Spread Spectrum signal would be useful in combating the effects of narrowband fading experienced in the UHF radio environment.\nIn addition, vast improvements in the performance of digital integrated circuits is leading to the concept of the all-digital radio receiver. One such device made feasible by progress in miniaturisation is the Digital Matched Filter.\nThis work examines the operation of the Digital Matched Filter. It's applicability to Direct Sequence Spread Spectrum Systems is studied with a view to the possible implementation of such schemes in the Land Mobile Radio environment. Emphasis is placed on achieving maximum utilisation of the Digital Matched Filter resource. Information obtained from Digital Matched Filters in a complex baseband receiver is shown to assist rapid code synchronization, RF carrier recovery, and measurement of the multipath transmission channel profile.\nA practical transmitter/receiver pair is described, and the results obtained suggest that future designers of Direct Sequence Spread Spectrum receivers may obtain benefits from the Digital Matched Filter approach, particularly in the area of rapid code synchronization.
Flow-Based Optimization of Products or Devices (2020)

Flow-based optimization of products and devices is an immature field compared to corresponding topology optimization based on solid mechanics [...]
Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes (1998)

We examined the contribution of specific EP receptors in regulating cell growth. By RT-PCR and northern hybridization, adult human keratinocytes express mRNA for three PGE2 receptor subtypes associated with cAMP signaling (EP2, EP3, and small amounts of EP4). In actively growing, non-confluent primary keratinocyte cultures, the EP2 and EP4 selective agonists, 11-deoxy PGE1 and 1-OH PGE1, caused complete reversal of indomethacin-induced growth inhibition. The EP3/EP2 agonist (misoprostol), and the EP1/EP2 agonist (17-phenyl trinor PGE2), showed less activity. Similar results were obtained with agonist-induced cAMP formation. The ability of exogenous dibutyryl cAMP to completely reverse indomethacin-induced growth inhibition support the conclusion that growth stimulation occurs via an EP2 and/or EP4 receptor-adenylyl cyclase coupled response. In contrast, activation of EP3 receptors by sulprostone, which is virtually devoid of agonist activity at EP2 or EP4 receptors, inhibited bromodeoxyuridine uptake in indomethacin-treated cells up to 30%. Although human EP3 receptor variants have been shown in other cell types to markedly inhibit cAMP formation via a pertussis toxin sensitive mechanisms, EP3 receptor activation and presumably growth inhibition was independent of adenylyl cyclase, suggesting activation of other signaling pathways.
Impact of coated calcium carbonate nanofillers and annealing treatments on the microstructure and gas barrier properties of poly(lactide) based nanocomposite films (2015)

ABSTRACT Amorphous poly(lactide) (PLA) and nanocomposite films were prepared from melt‐blending with precipitated calcium carbonate nanofillers (PCC). Nanocomposites based on uncoated PCC (PCC‐UT), stearic acid coated PCC (PCC‐S), and poly(ε‐caprolactone) coated PCC (PCC‐P) were investigated for an inorganic content fixed to 8 wt %. Using coated nanofillers allowed preserving both PLA average molar mass and thermal stability while enhancing the nanofiller dispersion state. Poly(ε‐caprolactone) was identified as the best coating for optimized morphology and thermal properties. Maxwell law accurately described the increase in oxygen barrier properties observed for the nanocomposites based on PCC‐S. A modified Maxwell law was proposed to take account of the additional increase in barrier properties evidenced for the PLA/PCC‐P nanocomposites and assigned to the particularly strong compatibility between PCL and PLA. Different annealing conditions were investigated to respectively study the impact of physical ageing and PLA crystallization on gas permeability. Different extents of physical ageing did not significantly modify the oxygen transport properties. However, a high permeability decrease was observed for the semicrystalline nanocomposites with respect to the amorphous reference PLA film. Finally, the gain in barrier properties was shown to result from both contribution of the nanofillers and the crystalline phase. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54 , 649–658
Lung Tissue Mechanics and Extracellular Matrix Remodeling in Acute Lung Injury (2001)

elastance; collagen fibers; elastin; paraquat
Contrast Transcranial Doppler Ultrasound in the Detection of Right-to-Left Shunts (1999)

TCD performed twice with 2 provocation maneuvers using Echovist is a sensitive method to identify cardiac right-to-left shunts also identified by TEE.