gebhart/patrepeval huggingface dataset:
An improved interface for capillary zone electrophoresis-mass spectrometry (1988)

We have recently developed an improved electrospray ionization interface for capillary electrophoresis mass-spectrometry (CZE-MS). Our initial interface employed a vacuum deposited metal film at the exit of the capillary to make an electrical contact with he eluting buffer and establish the electrospray field gradient. This interface did, however, impose significant limitations on the range of capillary electrophoretic (CE) separations that could be performed. To circumvent these limitations, an interface that does not require a metalized tip was designed nd developed. In the new approach, the electrical contact at the column exit is made through a flowing liquid sheath. The principal advantage of this interface is that it allows operation with a much broader range of electrophoresis conditions. The sheath flow can be readily varied in both composition and volume. An electrospray ionization spectrum is given for a previously intractable buffer solution. 5 refs., 2 figs.
Reliable detection of LSB steganography in color and grayscale images (2001)

A large number of commercial steganographic programs use the Least Significant Bit embedding (LSB) as the method of choice for message hiding in 24-bit, 8-bit color images, and grayscale images. It is commonly believed that changes to the LSBs of colors cannot be detected due to noise that is always present in digital images. In this paper, we describe a new very accurate and reliable method that can detect LSB embedding in randomly scattered pixels in both 24-bit color images and 8-bit grayscale or color images. It is based on our previous work on lossless data embedding [1]. By inspecting the differences in the number of regular and singular groups for the LSB and the "shifted LSB plane", we can reliably detect messages as short as 0.03bpp.
Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) (2017)

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The expression of four mitochondrial DNA encoded proteins (MT-ND3, MT-CO2, MT-ATP6 and MT-ATP8) is suppressed, by up to 35-fold. This high selection pressure metabolically synchronizes the surviving cancer cell sub-population towards a predominantly glycolytic phenotype, resulting in metabolic inflexibility. We directly validated this Doxycycline-induced glycolytic phenotype, by using metabolic flux analysis and label-free unbiased proteomics. Next, we identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for metabolically targeting the Doxycycline-resistant CSC population (Atovaquone, Irinotecan, Sorafenib, Niclosamide, Chloroquine, and Stiripentol). This new combination strategy allows for the more efficacious eradication of CSCs with Doxycycline, and provides a simple pragmatic solution to the possible development of Doxycycline-resistance in cancer cells. In summary, we propose the combined use of i) Doxycycline (Hit-1: targeting mitochondria) and ii) Vitamin C (Hit-2: targeting glycolysis), which represents a new synthetic-lethal metabolic strategy for eradicating CSCs. This type of metabolic Achilles' heel will allow us and others to more effectively "starve" the CSC population.
Enhance Information Derivation by In-Network Semantic Mashup for IoT Applications (2018)

In Internet of Things (IoT) applications, the users usually are not interested in the raw data that are produced by the physical devices. Through semantic mashup, the new information can be derived, which can be meaningful to the users. In this paper, we identify that the in-network capabilities of Internet routers can overcome the inefficiency in the data request and semantic mashup that is initiated either by the user directly or through an IoT middleware (e.g. oneM2M platform). We propose the high level architecture of the in-network semantic mashup function of an Internet router. The algorithm of processing semantic mashup integrated data request message is proposed as well as the data processing procedure. The simulation results show the significant performance improvements in the transported data overhead and the user experienced latency.
Hollow cathode sustained plasma microjets: Characterization and application to diamond deposition (2002)

Extending the principle of operation of hollow cathode microdischarges to a tube geometry has allowed the formation of stable, high-pressure plasma microjets in a variety of gases including Ar, He, and H2. Direct current discharges are ignited between stainless steel capillary tubes (d=178 μm) which are operated as the cathode and a metal grid or plate that serves as the anode. Argon plasma microjets can be sustained in ambient air with plasma voltages as low as 260 V for cathode-anode gaps of 0.5 mm. At larger operating voltage, this gap can be extended up to several millimeters. Using a heated molybdenum substrate as the anode, plasma microjets in CH4/H2 mixtures have been used to deposit diamond crystals and polycrystalline films. Micro-Raman spectroscopy of these films shows mainly sp3 carbon content with slight shifting of the diamond peak due to internal stresses. Optical emission spectroscopy of the discharges used in the diamond growth experiments confirms the presence of atomic hydrogen and CH radicals.
A pass transistor design methodology for 256 Mbit DRAM and beyond (2002)

A novel pass transistor design methodology to optimize gate oxide thickness (t/sub ox/), booted wordline voltage (V/sub WL/), substrate bias (V/sub sub/), and processing conditions is presented in this paper. It is found that for a gate length of 0.3 /spl mu/m a t/sub ox/ of about 85 /spl Aring/ (which is much thicker than the /spl sim/65 /spl Aring/ t/sub ox/ for 0.25 /spl mu/m logic technology) to support a V/sub WL/ of 3.75 V, a V/sub sub/ of about -1 V, and As LDD are the optimum technological choices for 256 Mbit DRAM.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pitfalls of tungsten multileaf collimator in proton beam therapy (2011)

MLC is an efficient way for beam shaping and overall cost reduction device in proton therapy. However, based on this study, tungsten seems to be not an optimal material for MLC in proton beam therapy. Usage of tungsten MLC in clinic may create unnecessary risks associated with the secondary neutrons and induced radioactivity for patients and staff depending on the patient load. A careful selection of material for manufacturing of an optimal MLC for proton therapy is thus desired.
Effects of Phase Matching Pattern on Pulse Laser-Arc Hybrid Welding Process (2014)

This paper proposed a method on accurate phase matching control between the pulse laser and the AC TIG arc in real time, and a pulse laser-arc hybrid heat source phase matching control system is developed as well. With the utilization of this system in two typical matching cases that the pulse laser acts on the peak and the trough of the arc welding current waveform, effect regulations on weld formation, weld penetration depth and hybrid plasma shape are studied during welding on magnesium alloy AZ61. Results indicate that, when the pulse laser acting on the peak of arc welding current waveform, the weld formation is better than that of on the trough. However, when pulse laser act on the arc trough the weld penetration depth is deeper than that of on the peak.
Petroleum Sulfonate Utilization in Enhanced Oil Recovery Systems (1976)

American Institute of Mining, Metallurgical, and Petroleum Engineers, Inc. Abstract Petroleum sulfonates are currently being evaluated extensively in surfactant enhanced oil recovery processes in laboratory studies, pilot field trials, and in semicommercial field tests. Consideration of surfactant manufacturing, product availability projections, product properties and laboratory oil recovery tests among available types of petroleum sulfonates establish that those produced directly and economically from abundantly available petroleum refinery feedstocks can be petroleum refinery feedstocks can be produced in volume to meet oil industry produced in volume to meet oil industry requirements. The diversity of crude oils ana reservoir constraints make it desirable to tailor surfactant systems to optimize oil recovery. Introduction Most of the many hundreds of currently existing U.S. patents directed to surfactant enhanced oil recovery processes disclose the use of petroleum sulfonates singularly or in various surfactant combinations. In spite of this plethora of petroleum sulfonate use claims, the technical literature is almost devoid of comparative information relative to the various types of available petroleum sulfonate products — those derived as low yield sulfonation "by-products" and those by direct higher yield petroleum sulfonation in which the sulfonate is the primary product — and to processes for their manufacture. Accordingly, this paper, addresses itself to filling this need, with greatest emphasis being placed on the comparison between placed on the comparison between conventional petroleum mahogany sulfonates and the newer petroleum sulfonates produced by direct petroleum sulfonation recently developed by the present authors and their associates. It is apparent that for the most part the oil industry's main technical thrust has been primarily directed towards developing the complex oil recovery process technology, whereas surfactant product and process development has been a secondary process development has been a secondary consideration, with some notable exceptions to be sure. While it has recently been reported (1) that crude oil sulfonate is now being produced by SO sulfonation, the resultant low yield sulfonate is directly converted to a dilute surfactant "slug" system and is thus beyond the scope of this study.
X-ray medical image processing using directional wavelet transform (2002)

Multi-resolution and multi-orientation are part of the biological mechanism of human visual system. The interest in multi-resolution image analysis has been growing rapidly. Comparatively, however, the multi-orientation method has received less attention. Based on the relationship between multifrequency channel decomposition and the wavelet model developed by Mallat [1989], a combined multiresolution/multi-orientation representation by directional wavelet transform (DWT) is introduced in this paper. Because of its high orientation selectivity, the DWT allows the processing of directional information more efficiently. It is applied successfully to feature enhancement and extraction of X-ray mammographic images.
Adeno‐associated Viral Vectors in Gene Therapy (2018)

Abstract Recombinant vectors based on a nonpathogenic human parvovirus, the adeno‐associated virus (AAV), have gained attention as a potentially safe and useful alternative to the more commonly used retroviral and adenoviral vectors. The past decade has witnessed the use of AAV vectors in the potential gene therapy of an ever‐increasing number of human diseases. The safety of AAV vectors in 165 Phase I/II and 1 Phase III clinical trials in humans to date and clinical efficacy in at least 8 human diseases have now been well documented. The availability of a vast repertoire of AAV serotype vectors, both naturally occurring and genetically engineered, and the availability of promising results with animal models of human diseases provide further impetus to the optimism that their use in the potential gene therapy of a wide variety of human diseases, both genetic and acquired, will continue in the foreseeable future. Key Concepts The first‐generation recombinant AAV vectors have shown efficacy in a number of Phase I/II clinical trials targeting various human diseases. The host immune response to AAV vectors, especially at high doses, remains a challenging problem. The presence of preexisting antibodies to AAV is also a challenge as a significant proportion of the human population is sero‐positive for one or more of the AAV serotypes. The next‐generation AAV vectors have been developed that promise to circumvent most, if not all, of the problems associated with the first generation of AAV vectors. The next generation of AAV vectors, which are more efficacious at lower doses, are likely to prove safe and effective in the potential gene therapy of a wide variety of human diseases in the not‐too‐distant future.
An optical hemoglobinometer for whole blood (1989)

To overcome the disadvantages of the presently available hemoglobinometers, we have developed an optical instrument that measures the total hemoglobin (Hb) concentration in whole, undiluted blood. The device uses an infrared light-emitting diode to illuminate a capillary tube filled with a sample of whole blood. Light scattered in the blood travels a short distance down the length of the capillary tube, passes through a second light path, and reaches a photodetector, the output of which is amplified, digitized, and fed into a microprocessor. The microprocessor computes the Hb concentration as a nonlinear function of the light intensity. The optical device yielded Hb content measurements that correlated well with standard methods (r = 0.99, slope = 0.94, mean absolute difference = 0.75 g Hb/dl). Thus the accuracy appears to be less than 1 g Hb/dl. The advantages of the present device are as follows: 1) no chemical reaction is required (hence neither accurate dilutions nor toxic reagents are necessary); 2) it reads Hb concentration within a few seconds; 3) it can be operated by unskilled personnel; 4) it could be made portable and thus could be operated in the field, in rural settings, or at accident sites; 5) sample size is small (25-70 microliters); and 6) the same capillary tube can be centrifuged if a measure of hematocrit is also desired. A detailed parts list and circuit diagram are presented, and sources of error are discussed.
Fiber reinforced glasses and glass-ceramics for high performance applications (1986)

The development of fiber reinforced glass and glass-ceramic matrix composites is described. The general concepts involved in composite fabrication and resultant composite properties are given for a broad range of fiber and matrix combinations. It is shown that composite materials can be tailored to achieve high levels of toughness, strength, and elastic stiffness, as well as wear resistance and dimensional stability.
Thermal neutron detectors based on gadolinium-containing lanthanide-halide nanoscintillators (2010)

A novel concept for detection of thermal neutrons based on lanthanide halide nanocrystals containing gadolinium, an element with by far the highest thermal neutron capture cross section among all stable isotopes, is presented. Colloidal synthesis of GdF<sub>3</sub> nanocrystals, GdF<sub>3</sub> nanocrystals doped with Ce, and LaF<sub>3</sub> nanocrystals doped with Gd is reported. The nanocrystals were characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), dynamic light scattering (DLS) analysis, and steady state UV-VIS optical absorption and photoluminescence spectroscopy. Neutron detection has been confirmed in experiments with Gd-containing nanocrystalline material irradiated with <sup>252</sup>Cf neutron source.
A new method to locate faults in power networks based on Electromagnetic Time Reversal (2012)

The paper presents a new method based on the Electromagnetic Time-Reversal (EMTR) for locating faults in power systems. The applicability of the EMTR to electromagnetic transients associated with traveling waves in transmission lines originated by the fault is theoretically demonstrated. A new fault location technique is then proposed and illustrated for a simple case of a single-conductor transmission line, for which the performance of the proposed technique in terms of location accuracy is discussed. The use of the EMTR technique appears to be particularly promising for locating faults in passive and active electrical distribution networks in view of their radial structure.
“What Do You Mean by That?” A Parser-Independent Interactive Approach for Enhancing Text-to-SQL (2020)

In Natural Language Interfaces to Databases systems, the text-to-SQL technique allows users to query databases by using natural language questions. Though significant progress in this area has been made recently, most parsers may fall short when they are deployed in real systems. One main reason stems from the difficulty of fully understanding the users' natural language questions. In this paper, we include human in the loop and present a novel parser-independent interactive approach (PIIA) that interacts with users using multi-choice questions and can easily work with arbitrary parsers. Experiments were conducted on two cross-domain datasets, the WikiSQL and the more complex Spider, with five state-of-the-art parsers. These demonstrated that PIIA is capable of enhancing the text-to-SQL performance with limited interaction turns by using both simulation and human evaluation.
An Efficient Signal Detection Method for Uplink Multiuser Systems Based on Collaborative Spatial Multiplexing (2011)

In this letter, we propose an efficient signal detection method for uplink multiuser systems based on collaborative spatial multiplexing (CSM). The proposed method achieves near-optimal performance and shows only 0.8dB loss at the target frame error rate (FER) of 10-2. Moreover, the error performance of each user is almost the same in the proposed method, which is an important property in a multiuser MIMO system where each user's error performance must satisfy some fixed error rate criteria.
Coupled Serial and Parallel Non-uniform SQUIDs (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Patrick Longhini, Susan Berggren, Antonio Palacios, Anna Leese de Escobar, Visarath In; Coupled Serial and Parallel Non‐uniform SQUIDs. AIP Conf. Proc. 19 April 2011; 1339 (1): 254–259. https://doi.org/10.1063/1.3574861 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Abstract 4331: Discovery of potent 2-Indole-acylsulfonamide Mcl-1 inhibitors using structure guided fragment-based methods (2016)

Abstract Mcl-1 (Myeloid cell leukemia 1), a member of the Bcl-2 family of proteins, is overexpressed and amplified in various cancers and is one of the major acquired resistance mechanisms for many anticancer therapies. Targeting Mcl-1 with small molecules is very challenging because Mcl-1 exerts its effects through protein-protein interactions. Here we describe our continuing efforts in the discovery of potent and selective Mcl-1 inhibitors using fragment-based methods and structure-based design. We previously described the discovery of small-molecule Mcl-1 inhibitors containing a 2-indole-carboxylic core that primarily bind to the P2 pocket. In order to enhance potency, we extend our molecules to occupy the entire BH3 binding interface. A number of P4 site hits were identified using a fragment-based screening while the P2 pocket of Mcl-1 was saturated with our previously reported lead. P4 site ligands were then linked to our initial lead guided by the ternary Mcl-1 structure containing both P2 and P4 units using an acylsulfonamide as a synthetic handle that retained the critical charged-charged interaction with R263. X-ray co-crystal structures of new inhibitors occupying both P2 and P4 sites bound Mcl-1 provided detailed information on how these small-molecules bind to the target and guided subsequent potency optimization. From the efforts, we discovered a novel series of 2-indole-acylsulfonamide containing Mcl-1 inhibitors that exhibit low nanomolar binding affinities to the target and greater than 500-fold selectivity over Bcl-xL. These compounds represent useful starting points for the discovery of clinically useful Mcl-1 inhibitors for the treatment of a wide variety of cancers. Citation Format: Subrata Shaw, James Chris Tarr, Nicholas Pelz, Zhiguo Bian, Johannes Belmar, Bin Zhao, Craig Goodwin, Allison Arnold, John Sensintaffar, Olivia Rossanese, Taekyu Lee, Edward Olejniczak, Stephen Fesik. Discovery of potent 2-Indole-acylsulfonamide Mcl-1 inhibitors using structure guided fragment-based methods. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4331.
ChemInform Abstract: SYNTHESIS AND HYPOTENSIVE ACTIVITY OF A SERIES OF 2‐SUBSTITUTED 5,6‐DIMETHOXYINDAZOLES (1978)

Abstract Durch Cyclisierung der Schiffschen Basen (III) oder der Azide (VII) werden die Dimethoxyindazole (IV) hergestellt.
Duplex ultrasonic imaging system with repetitive excitation of common transducer in Doppler modality (1984)

First Page
Antibacterial Implant Surfaces (2012)

The antibacterial effects of copper/titanium oxide coatings have been investigated. TiAl6V4 plates were sur- face modified by plasmaelectrolytic oxidation with a porous oxide layer as a mask for the following galvanic deposition of copper. The copper/titanium oxide composite layer was then glass sphere blasted to get a partly copper covered sur- face and an average copper load of about 1µg/mm 2 .T he bactericidal tests have been carried out with Staphylococcus aureus. The growth inhibition tests showed a toxic effect on adhering bacteria after 4 hours. The released copper ions can reduce the planktonic bacteria after 24 hours by 10 5 order of magnitude. This value is reached for biofilm forming bacte- ria in 2 hours.
<title>Clustering analysis for gene expression data</title> (1999)

The recent development of cDNA microarray allows ready access to large amount gene expression patterns for many genetic materials. Gene expression of tissue samples can be quantitatively analyzed by hybridizing fluor-tagged mRNA to targets on a cDNA microarray. Ratios of average expression level arising from co-hybridized normal and pathological samples are extracted via image segmentation, thus the gene expression pattern are obtained. The gene expression in a given biological process may provide a fingerprint of the sample development, or response to certain treatment. We propose a K-mean based algorithm in which gene expression levels fluctuate in parallel will be clustered together. The resulting cluster suggests some functional relationships between genes, and some known genes belongs to a unique functional classes shall provide indication for unknown genes in the same clusters.
Elimination of Plasmon Losses and Enhanced Light Extraction of Top-Emitting Organic Light-Emitting Devices Using a Reflective Subelectrode Grid (2017)

We demonstrate high-efficiency light extraction for top-emitting organic light-emitting devices (OLEDs) comprising a transparent conductive oxide on the surface of a nondiffractive, reflecting metal-coated scattering grid located beneath the organic active region. The grid scatters light trapped in waveguide modes without changing the device electrical properties or causing significant plasmonic losses. This results in an increase in external quantum efficiency for green phosphorescent organic light-emitting devices from 20 ± 1% to 30 ± 2%, for structures without and with the reflecting grid. Adding a low refractive index capping layer reduces the spectral angular dependence characteristic of top-emitting OLEDs. The improvement in light extraction by substrate modification allows for optimization of the optical design without necessitating changes in the design or structure of the OLEDs themselves.