gebhart/patrepeval huggingface dataset:
Standardization of recipe for the preparation of dried wild pomegranate (anardana)-long gourd appetizer (2013)

Studies were undertaken to prepare a palatable and nutritious appetizer from dried wild pomegranate in combination with long gourd juice. Different combinations of dried pomegranate powder (612g), long gourd juice (13-19g) with herbs and spices were tried for the standardization of product. Out of 7 recipes, the best recipe (R4) consisting of 9g wild pomegranate powder, 16g long gourd juice, 0.4g mint leaves powder, 0.4g ginger powder, 0.5g common salt, 1.5g black salt powder, 41.50g sugar powder, 0.25g cumin powder, 0.1g cardamom powder, 0.4g black pepper powder and 0.02g carmozine was standardized for the preparation of appetizers from freshly dried as well as 6 months stored arils. The appetizers prepared from the best recipe had appealing colour, body, flavour and good sugar: acid blend. The quality of the appetizers prepared from 6 months stored arils was comparable with that of freshly prepared; however negligible changes in sensory and chemical characteristics were found. The sale price for 700 ml bottle of appetizer was worked out to be very low as compared to the market price of any fruit squash available in the market.
Multi-Dimensional Database Allocation for Parallel Data Warehouses (2000)

Data allocation is a key performance factor for parallel database systems (PDBS). This holds especially for data warehousing environments where huge amounts of data and complex analytical queries have to be dealt with. While there are several studies on data allocation for relational PDBS, the specific requirements of data warehouses have not yet been sufficiently addressed. In this study, we consider the allocation of relational data warehouses based on a star schema and utilizing bitmap index structures. We investigate how a multi-dimensional hierarchical data fragmentation of the fact table supports queries referencing different subsets of the schema dimensions. Our analysis is based on realistic parameters derived from a decision support benchmark. The performance implications of different allocation choices are evaluated by means of a detailed simulation model. 1
Decreased Chicken Ovalbumin Upstream Promoter Transcription Factor II Expression in Tamoxifen-Resistant Breast Cancer Cells (2006)

Tamoxifen (TAM) is successfully used for the treatment and prevention of breast cancer. However, many patients that are initially TAM responsive develop tumors that are antiestrogen/TAM resistant (TAM-R). The mechanism behind TAM resistance in estrogen receptor alpha (ERalpha)-positive tumors is not understood. The orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor (COUP-TF)-I interacts directly with 4-hydroxytamoxifen (4-OHT)- and estradiol (E(2))-occupied ERalpha, corepressors NCoR and SMRT, and inhibit E(2)-induced gene transcription in breast cancer cells. Here we tested the hypothesis that reduced COUP-TFI and COUP-TFII correlate with TAM resistance. We report for the first time that COUP-TFII, but not COUP-TFI, is reduced in three antiestrogen/TAM-R cell lines derived from TAM-sensitive (TAM-S) MCF-7 human breast cancer cells and in MDA-MB-231 cells compared with MCF-7. ERalpha and ERbeta protein expression was not different between TAM-S and TAM-R cells, but progesterone receptor (PR) was decreased in TAM-R cells. Further, E(2) increased COUP-TFII transcription in MCF-7, but not TAM-R, cells. Importantly, reexpression of COUP-TFII in TAM-S cells to levels comparable to those in MCF-7 was shown to increase 4-OHT-mediated growth inhibition and increased apoptosis. Conversely, knockdown of COUP-TFII in TAM-S MCF-7 cells blocked growth inhibitory activity and increased 4-OHT agonist activity. 4-OHT increased COUP-TFII-ERalpha interaction approximately 2-fold in MCF-7 cells. COUP-TFII expression in TAM-R cells also inhibited 4-OHT-induced endogenous PR and pS2 mRNA expression. These data indicate that reduced COUP-TFII expression correlates with acquired TAM resistance in human breast cancer cell lines and that COUP-TFII plays a role in regulating the growth inhibitory activity of TAM in breast cancer cells.
Cloud identity management security issues & solutions: a taxonomy (2014)

Abstract Purpose Cloud computing systems represent one of the most complex computing systems currently in existence. Current applications of Cloud involve extensive use of distributed systems with varying degree of connectivity and usage. With a recent focus on large-scale proliferation of Cloud computing, identity management in Cloud based systems is a critical issue for the sustainability of any Cloud-based service. This area has also received considerable attention from the research community as well as the IT industry. Numerous Cloud Identity Management Systems (IDMSs) have been proposed so far; however, most of those systems are neither widely accepted nor considered highly reliable due to their constraints in terms of scope, applicability and security. In order to achieve reliability and effectiveness in IDMs for Cloud, further extensive research needs to be carried out to critically examine Cloud based IDMSs and their level of security. Methods In this work, we have holistically analyzed Cloud IDMSs to better understand the general as well as the security aspects of this domain. From the security perspective, we present a comprehensive list of attacks that occur frequently in Cloud based IDMSs. In order to alleviate those attacks, we present a well-organized taxonomy tree covering the most desired features essential for any Cloud-based IDMSs. Additionally, we have specified various mechanisms of realization (such as access control polices, encryption, self-service) against each of the features of Cloud IDMSs. We have further used the proposed taxonomy as an assessment criterion for the evaluation of Cloud based IDMSs. Results Our in-depth analysis of various Cloud based IDMSs reveals that most of the systems do not offer support to all the essential features of Cloud IDMS and the ones that do, have their own certain weaknesses. None of the discussed techniques heuristically covers all the security features; moreover, they lack compliance to international standards which, understandably, undermines their credibility. Conclusion Presented work will help Cloud subscribers and providers in understanding the available solutions as well as the involved risks, allowing them to make more knowledgeable decisions while selecting potential Cloud IDMSs that best suits their functional and security requirements.
(Utilization and processing of middle or late ripening variety citrus fruits. Part XVI). White precipitates found in syrup of canned iyo orange (Citrus iyo hort. ex Tanaka) segments with and without addition of cyclodextrin. (1991)

シクロデキストリン類添加による,イヨカンシラップ漬缶詰の食味改善試験中に,貯蔵期間の延長とともに,そのシラップが強く白濁する現象を見出した.対照区を含めた各区の白濁物質の組成について検討した結果は次のとおりである.1. シクロデキストリンを添加しない通常のイヨカンシラップ漬缶詰に生成した白濁物質は赤外および紫外吸収スペクトルにより,ヘスペリジンが主成分をなすものと確認された.2. β-シクロデキストリン添加イヨカン缶詰に生成した白濁物質は,微小三日月状の結晶形,赤外吸収スペクトル等および溶解度の比較試験の結果などから,イヨカン砂じょう膜中の,主として脂肪酸類とステロール類がβ-シクロデキストリンに包接されたものと推定された.3. α-シクロデキストリンを主成分とするデキシーパールK-100を添加したイヨカン缶詰に生成した白濁物質は,水およびアルコールに対する溶解度,結晶形(六角板状)および赤外吸収スペクトルからみて,脂肪酸を包接したα-シクロデキストリンであると判断された.この結晶は缶詰イヨカンのシラップ中だけでなく,果肉中にも生成し,口に入れるとざらつき,砂をかむような嫌な食感を与えた.4. αおよびβ-シクロデキストリン添加によるイヨカン缶詰の苦味改善の試みは,シラップの白濁や結晶の析出による食感の劣化などのため,実用化は困難と判断された.
c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. (1992)

To determine the type of mutation induced by 8-hydroxyguanine in a mammalian system, we examined the mutations induced by a synthetic c-Ha-ras protooncogene containing 8-hydroxyguanine in the second position of codon 12 (GGC) in NIH3T3 cells. Transfection of this gene significantly increased the number of transformed foci. The c-Ha-ras gene present in these foci was analyzed by the polymerase chain reaction-restriction enzyme method. Interestingly, sequence analysis revealed random mutations at the modified site (G----T, G----A, and G----C) as well as mutations of the adjacent G on the 5'-side of 8-hydroxyguanine (G----A and G----T).
Accumulation of V 7.2-J 33 invariant T cells in human autoimmune inflammatory lesions in the nervous system (2004)

T cells expressing an invariant TCR alpha chain and NK cell markers are expected to exhibit unique functions. Whereas much attention has been paid to CD1d-restricted NKT cells, a second NKT cell population bearing an invariant AV19-AJ33 TCR has recently been identified in mice and humans. Selection and/or expansion of this population require B cells, and would involve a non-classical class I-related molecule MR1. Although their preferential distribution in the gut mucosa indicates their role in the host response at the site of pathogen entry, it remains unknown whether they play an alternative role at different sites or in immunological disorders. Using single-strand conformation polymorphism clonotype analysis, we investigated the presence of the human AV19-AJ33 T cells (V(alpha)7.2-J(alpha)33 T cells) in autopsy samples from multiple sclerosis (MS) patients as well as in nerve biopsy samples from chronic inflammatory demyelinating polyneuropathy (CIDP) patients. Here we report that the V(alpha)7.2-J(alpha)33 T cells are accumulated in some of the central nervous system lesions of MS and in the majority of the peripheral nerve samples from CIDP. We have previously revealed that CD1d-restricted, V(alpha)24-J(alpha)Q NKT cells are remarkably reduced in the peripheral blood from MS. However, V(alpha)7.2-J(alpha)33 T cells are not reduced in the peripheral blood from MS and could be detected in a large majority of the cerebrospinal fluid samples obtained during relapse of MS. The present results indicate that the V(alpha)7.2-J(alpha)33 T cells are involved in the autoimmune inflammatory lesions.
A Tobacco Etch Virus Protease with Increased Substrate Tolerance at the P1' position (2013)

Site-specific proteases are important tools for in vitro and in vivo cleavage of proteins. They are widely used for diverse applications, like protein purification, assessment of protein-protein interactions or regulation of protein localization, abundance or activity. Here, we report the development of a procedure to select protease variants with altered specificity based on the well-established Saccharomyces cerevisiae adenine auxotrophy-dependent red/white colony assay. We applied this method on the tobacco etch virus (TEV) protease to obtain a protease variant with altered substrate specificity at the P1' Position. In vivo experiments with tester substrates showed that the mutated TEV protease still efficiently recognizes the sequence ENLYFQ, but has almost lost all bias for the amino acid at the P1' Position. Thus, we generated a site-specific protease for synthetic approaches requiring in vivo generation of proteins or peptides with a specific N-terminal amino acid.
Significados, silencios y olvidos asociados a la experiencia del desplazamiento forzado (2015)

La investigación analizó los significados atribuidos a las pérdidas múltiples y los movimientos del duelo en personas desplazadas. Se realizó un estudio cualitativo descriptivo con enfoque fenomenológico-hermenéutico. Participaron 18 personas en situación de desplazamiento. Se desarrollaron categorías relacionadas con los cambios y pérdidas vinculadas con la vida de antes, la salida del campo y la llegada a la ciudad. En este artículo se presentan dos categorías emergentes: primero, los significados que los afectados atribuyen a la experiencia del desplazamiento; segundo, los silencios y los olvidos como respuestas a la violencia vivida. Los significados construidos alrededor del desplazamiento permiten comprender las distintas posiciones frente a dicha experiencia y las posibilidades o dificultades para la reconstrucción de la vida. Los silencios y los olvidos son formas particulares de responder a esta violencia.
Regulation of the RON Receptor Tyrosine Kinase Expression in Macrophages: Blocking the RON Gene Transcription by Endotoxin-Induced Nitric Oxide (2000)

Previous studies have shown that activation of the RON receptor tyrosine kinase inhibits inducible NO production in murine peritoneal macrophages. The purpose of this study is to determine whether inflammatory mediators such as LPS, IFN-gamma, and TNF-alpha regulate RON expression. Western blot analysis showed that RON expression is reduced in peritoneal macrophages collected from mice injected with a low dose of LPS. The inhibition was seen as early as 8 h after LPS challenge. Experiments in vitro also demonstrated that the levels of the RON mRNA and protein are diminished in cultured peritoneal macrophages following LPS stimulation. TNF-alpha plus IFN-gamma abrogated macrophage RON expression, although individual cytokines had no significant effect. Because LPS and TNF-alpha plus IFN-gamma induce NO production, we reasoned that NO might be involved in the RON inhibition. Two NO donors, S-nitroglutathione (GSNO) and (+/-)-S-nitroso-N-acetylpenicillamine (SNAP), directly inhibited macrophage RON expression when added to the cell cultures. Blocking NO production by NO inhibitors like TGF-beta prevented the LPS-mediated inhibitory effect. In Raw264.7 cells transiently transfected with a report vector, GSNO or SNAP inhibited the luciferase activities driven by the RON gene promoter. Moreover, GSNO or SNAP inhibited the macrophage-stimulating protein-induced RON phosphorylation and macrophage migration. We concluded from these data that RON expression in macrophages is regulated during inflammation. LPS and TNF-alpha plus IFN-gamma are capable of down-regulating RON expression through induction of NO production. The inhibitory effect of NO is mediated by suppression of the RON gene promoter activities.
Advances in understanding the pathogenesis of cerebrovascular vasculopathy in sickle cell anaemia (2013)

Cerebral vasculopathy is the most severe complication to affect children with sickle cell anaemia and its pathophysiology is complex. Traditionally, small-vessel occlusion by intravascular sickling and sludging was considered to underlie the strokes but, in the last 20 years, progressive major cerebral vessel involvement has become recognized as the principal responsible factor. Macrovasculopathy is well detected by abnormally high velocities on transcranial Doppler and with magnetic resonance angiography (MRA), and is responsible for the majority of overt strokes. Silent infarcts are ischaemic lesions detected by magnetic resonance imaging (MRI) in patients without history of stroke. They are associated with compromised cognitive functioning. The present review discusses the pathophysiologal mechanisms that could be involved in the development of cerebral vasculopathy, such as inflammation and hypoxia, anaemia, haemolysis and the resulting decreased nitric oxide bioavailability, genetic factors, impaired blood rheology and particular local haemodynamic profiles.
Reliability Challenges in Fabrication of Flexible Hybrid Electronics for Human Performance Monitors: A System-Level Study (2019)

Flexible hybrid electronics (FTIE) interface rigid electronic components with flexible sensors, circuits, and substrates. This paper reports the reliability improvement of an FTIE human performance monitor (TIPM), designed to monitor electrocardiography (ECG) signals. The 50.8 mm × 50.8 mm TIPM is fabricated on Kapton TIN polyimide (PI) substrate with flexible gold (Au) ECG electrodes on one side of the substrate and rigid electronic components for signal processing and communication mounted on the other side of the substrate. Our previously reported TIPMs demonstrated reliability issues due to: 1) cracking of the copper (Cu) circuitry and 2) thinning and lack of adhesion at the printed Au and plated Cu interface that connected printed sensors to the Cu circuitry. Both failure mechanisms resulted in electrical opens in the circuit, which caused device failure. We explored effects of different design parameters, such as PI substrate thickness (50 versus 125 μm), Cu circuit thickness (2 versus 6 μm), solder reflow temperature [205 °C for Tin-Lead (Sn-Pb) versus 175 °C for Tin-Bismuth (Sn-Bi) solder], solder pad design, and optimized inkjet printing (printing on bare Cu versus Au-plated Cu) on improving FTIE reliability. Test vehicles (TVs) with different combinations of these factors were fabricated and bend-tested to determine the most robust configuration. TVs with 50-μm-thick PI substrate, 6-μm-thick Cu circuit, Sn-Bi solder, redesigned solder pads with rounded corners, and printed Au traces on Au plated Cu pads demonstrated the best reliability results.
Essential role of aspartokinase in L-threonine production by Escherichia coli W mutants. (1986)

We previously constructed an L-threonine-producing strain of E. coli W, KY8280, which is an Ile+ revertant of KY8279 which requires L-methionine, α, ε-diaminopimelic acid and L-isoleucine [H. Kase et al., Agric. EM. Chem., 35, 2089 (1971)]. From KY8280, another L-threoninehyperproducing strain, KY8366, was obtained as an α-amino-β-hydroxyvaleric acid (AHV, a threonine analog)-resistant mutant. Enzymatic analysis revealed that KY8280 constitutively expressed 8-fold higher L-threonine-sensitive aspartokinase I activity than KY8279. In addition, KY8366 constitutively expressed 13-fold higher L-lysine-sensitive aspartokinase III activity than KY8280. Such elevated levels of aspartokinases may contribute to the hyperproduction of L-threonine by these mutant strains. KY8366 produced 28 mg/ml of L-threonine in a culture medium fed with 12% glucose.
Distributed magnetic sensor using reflection coefficients from both ends of single magnetic coaxial cable (2020)

The principle of the distributed magnetic sensor by magneto-impedance effect with time domain reflectometry was demonstrated, and the position and strength of the magnetic field were detected simultaneously with a magnetic coaxial cable. This paper presents a distributed magnetic sensor using the forward and reverse reflection coefficients S11 and S22 from both ends of a single magnetic coaxial cable. The method using reflection coefficients includes novel features such as: (1) improvement of the signal-noise ratio for equivalent measurement time and (2) cancellation of the time fluctuation by jitter. It is confirmed that the SNR of a reflected wave with a vector network analyzer is improved by 21.3 dB compared to that of an oscilloscope. Furthermore, the attenuation of a signal wave can be compensated by synthesizing the reflected waves from both ends. As a result, the signal wave is less affected by the attenuation along the length of the cable and is improved by 19.0 dB at the position of 180 mm.
An Amphiphilic Poly(phenylene ethynylene) as the Structure-Directing Agent for Periodic Nanoscale Silica Composite Materials (2005)

We have synthesized optically active nanostructured composite materials by using an amphiphilic semiconducting polymer, a poly(phenylene ethynylene) (PPE), and a conventional ammonium surfactant as the structure-directing agents. The PPE consists of phenylene units para-substituted with an octyloxy chain and a charged trimethylammoniumethoxy group, resulting in a surfactant-like structure that can assemble into cylindrical micelles. The resulting silica/organic composite material has a hexagonal honeycomb structure with a repeat distance of 45.3 A, as confirmed by low-angle X-ray diffraction and transmission electron microscopy. Scanning electron microscopy indicates that the larger scale particle size is on the order of micrometers. The incorporation of the polymer into the composite was confirmed by elemental analysis, photoluminescence spectroscopy, and fluorescence microscopy. The polymer retains its photophysical properties in the composite, showing luminescence similar to polymers in the solution phase. The polymer displays a high degree of luminescence polarization anisotropy, indicating that the polymer chains are straight and isolated from each other in the composite.
Laser Applications of Transparent Polycrystalline Ceramic (2011)

pump power is 1.96W, the output of 1059.9nm and 1063.8nm are the same.From this point, utilizing this kind of ceramics laser as seed source to output two near-IR lasers amplified by double-clad fiber laser and then applying DFM methods to generate Terahertz radiation is our future blueprint of a compact Terahertz source.In our experiment on Nd:YSAG thin disk ceramics, we get CW laser output and demonstrated the dual-wavelength competitive output phenomenon.By comparing the different laser performance between Nd:YAG and Nd:YSAG and applying an energy transfer model, we discuss and give reasonable explanation for the dual-wavelength competetive output in Nd:YSAG as the disordered replacing of Al 3+ ions by Sc 3+ ions.This disordered replacing leads to a different energy transfer system in Nd:YSAG.Through the analysis of the behavior of the two wavelengths, we proposed a possible solution to make compact Terahertz source by using one laser source in the future. 7.
Tumor antigen specific iTreg accumulate in the tumor microenvironment and suppress therapeutic vaccination (2012)

Tumor specific antigens (TSA) provide an opportunity to mobilize therapeutic immune responses against cancer. To evade such responses, tumor development in immunocompetent hosts is accompanied by acquisition of both active and passive mechanisms of immune suppression, including recruitment of CD4+FoxP3+ regulatory T cells (Treg). Thymic derived Treg (nTreg) may recognize self-antigens in the tumor microenvironment, while peripherally induced Treg (iTreg) may preferentially recognize the same TSA which provide an opportunity for therapeutic immunity from peripheral T cells. In this study we provide a systematic analysis of nTreg and iTreg accumulation in the tumor microenvironment (TME) at the cellular level. iTreg accumulation to the TME was influenced by the abundance of a known TSA, and in the absence of a known TSA intratumoral Treg displayed a unique TCR repertoire from peripheral Treg. In vivo suppression assays demonstrate that cognate-antigen matched iTreg are more potent suppressors of CD4+ than are polyclonal iTreg or nTreg, but were unable to suppress CD8+ T cell proliferation. Suppression occurred only locally at the site of immunization, and correlated with decreased expression of CD80 and CD86 on CD11c positive cells. Although established tumors facilitated the induction of TSA-specific iTreg, these iTreg suppressed CD4+ T cell accumulation only locally to the TME. Tumor mediated suppression of CD8+ T cell immunity appeared independent of TSA-specific iTreg.