gebhart/patrepeval huggingface dataset:
Enhanced Low Complex Cost Function for H.264/AVC Intra Mode Decision (2011)

In order to reduce the computation of rate-distortion optimization (RDO) module of H.264/AVC intra encoder, this paper proposes an enhanced low complexity cost function. The enhanced cost function uses sum of absolute Hadamard-transformed differences (SATD) and mean absolute deviation of the residual block to estimate distortion part of the cost function. A threshold based large coefficients count is also used for estimating the bit-rate part. The proposed method improves the rate-distortion performance of the conventional fast cost functions while maintaining low complexity requirement. As the results, the encoding process can be significantly accelerated with use of the proposed cost function. Simulation results confirm that the proposed method reduces about 85% of computation of original encoder with negligible rate-distortion performance degradation.
Quantitative Gait Markers and Incident Fall Risk in Older Adults (2009)

Quantitative gait markers are independent predictors of falls in older adults. Gait speed and other markers, especially variability, should be further studied to improve current fall risk assessments and to develop new interventions.
Perchlorate in the United States. Analysis of Relative Source Contributions to the Food Chain (2006)

Perchlorate has been considered by some a potential threat to human health, especially to developing infants and children because it may inhibit iodide uptake by the sodium iodide symporter (NIS) of the thyroid. In the United States, during the last several decades, environmental perchlorate has had three recognized sources stemming from (a) its use as an oxidizer (including in rocket propellants), (b) its presence in Chilean nitrate fertilizer (CNF), and (c) natural production. An analysis of the relative source strengths and how they may influence entry into the food chain has not been conducted. Averaged over the last --60 years, we estimate that the source strengths have been (a) 10.6, (b) 0.75, and (c) 0.13-0.64 Gg/y for the United States as a whole. Of this, while (b) and (c) represent actual dispersed amounts, the figure in (a) is the amount of perchlorate produced and only a fraction (f) of it has been dispersed and often in a more localized fashion. In addition, dispersal of (b) has taken place only over agricultural land. Considering that the total land area in the United States is 5.5 x the arable land area, in terms of incorporation into the food chain,the figure cited in (b) has a proportionately greater impact. Most estimates of fwill thus suggest that over the considered period, the contribution of CNF to incorporation of perchlorate in the food chain has likely been comparable to oxidizer perchlorate, with natural production being a lesser source. Fireworks presently constitute a potentially important source of increasing importance but a quantitative impact cannotyet be assessed.
A Simple Algorithm of Superpixel Segmentation with Boundary Constraint (2016)

As one of the most popular image oversegmentations, superpixel has been commonly used as supporting regions for primitives to reduce computations in various computer vision tasks. In this paper, we propose a novel superpixel segmentation approach based on a distance function that is designed to balance among boundary adherence, intensity homogeneity, and compactness (COM) characteristics of the resulting superpixels. Given an expected number of superpixels, our method begins with initializing the superpixel seed positions to obtain the initial labels of pixels. Then, we optimize the superpixels iteratively based on the defined distance measurement. We update the positions and intensities of superpixel seeds based on the three-sigma rule. The experimental results demonstrate that our algorithm is more effective and accurate than previous superpixel methods and achieves a comparable tradeoff between superpixel COM and adherence to object boundaries.
Experimental Study of Velocity Fields in a Human Nasal Fossa by Laser Anemometry (1983)

Velocity fields were mapped in a model of a human nasal fossa by laser doppler velocimetry, an innovative, quantitative and noninvasive method of optical anemometry, and by computerization. Other pertinent parameters were also calculated. Studies made at different cross sections of the nasal fossa showed the very definite influence not only of shapes and dimensions but also of direction of flow on velocity fields. The turbinates had a streamlining effect on the velocity fields while the liminal valve had a directional effect. Flow was usually greater in the lower half of the fossa and closer to the septum. The flow was generally turbulent. Velocity fields appear to give more information on intranasal aerodynamics than the calculated flow and Reynolds number for the sections studied, and this allows one to at least theorize that there may be an aerodynamic basis to certain pathological conditions of the nasal airway and its adjoining cavities, the paranasal sinuses, and the eustachian tubes.
Use of Flocked Swabs and a Universal Transport Medium To Enhance Molecular Detection of <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> (2006)

The use of new flocked swabs, compared to kit swabs, enhanced the ability of three commercial nucleic acid amplification tests to detect low levels of Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acids when the organisms were diluted in a universal transport medium as mocked specimens.
Stress-Induced Outer Membrane Vesicle Production by Pseudomonas aeruginosa (2013)

As an opportunistic Gram-negative pathogen, Pseudomonas aeruginosa must be able to adapt and survive changes and stressors in its environment during the course of infection. To aid survival in the hostile host environment, P. aeruginosa has evolved defense mechanisms, including the production of an exopolysaccharide capsule and the secretion of a myriad of degradative proteases and lipases. The production of outer membrane-derived vesicles (OMVs) serves as a secretion mechanism for virulence factors as well as a general bacterial response to envelope-acting stressors. This study investigated the effect of sublethal physiological stressors on OMV production by P. aeruginosa and whether the Pseudomonas quinolone signal (PQS) and the MucD periplasmic protease are critical mechanistic factors in this response. Exposure to some environmental stressors was determined to increase the level of OMV production as well as the activity of AlgU, the sigma factor that controls MucD expression. Overexpression of AlgU was shown to be sufficient to induce OMV production; however, stress-induced OMV production was not dependent on activation of AlgU, since stress caused increased vesiculation in strains lacking algU. We further determined that MucD levels were not an indicator of OMV production under acute stress, and PQS was not required for OMV production under stress or unstressed conditions. Finally, an investigation of the response of P. aeruginosa to oxidative stress revealed that peroxide-induced OMV production requires the presence of B-band but not A-band lipopolysaccharide. Together, these results demonstrate that distinct mechanisms exist for stress-induced OMV production in P. aeruginosa.
Golden Path Analyzer (2003)

This paper describes a novel algorithm and deployed system Golden Path Analyzer (GPA) that analyzes clickstreams of people trying to complete the same task on a website. It finds the shortest, successful paths taken by users - 'golden paths' - and uses these as seeds for clickstream clusters. Other users are assigned to a cluster if their clickstream is a supersequence of the golden path. The advantages of this approach are that the resulting clusters are easily comprehended, they are few in number, correspond to semantically different strategies used by the users, and jointly partition all the clickstreams. GPA's key contribution over prior work in process funnels is that by not excluding users that make diversions from the golden path, GPA is able to assign more users to fewer clusters. Another key contribution is to use actual full clickstreams as cluster seeds to which supersequences of other users are added. Golden paths correspond to complete clickstreams that are based on actual user page transitions. GPA is particularly useful for site designers to improve processes such as shopping, returns and registration. Its analyses identify which web pages cause many users to deviate from a golden path, which links distract users and the percentage of users taking each golden path. GPA has demonstrated value on more than twenty client projects in diverse industries.
Aberration-corrected Czerny-Turner imaging spectrometer with a wide spectral region (2008)

A modified asymmetrical Czerny-Turner arrangement with a fixed plane grating is proposed to correct aberrations over a wide spectral region by analysis of the dependence of aberration correction for different wavelengths. The principle and method of aberration correction are described in detail. We compare the performance of this modified Czerny-Turner arrangement with that of the existing Czerny-Turner arrangement by using a practical Czerny-Turner imaging spectrometer example.
The influence of<i>Bacillus subtilis</i>RB14-C on the development of<i>Rhizoctonia solani</i>and indigenous microorganisms in the soil (2005)

The effect of soil inoculation with an antagonistic strain Bacillus subtilis RB14-C on the development of Rhizoctonia solani and changes occurring in soil and rhizosphere microbial communities were studied. RB14-C was added to the soil as a water suspension of the cells or as a broth culture. Application of cell suspensions to non-planted soil reduced the number of culturable bacteria. The density of R. solani and the number of filamentous fungi were not significantly affected by RB14-C. A similar effect was observed in the rhizosphere of tomato plants growns in bacterized soil. Broth cultures of RB14-C suppressed R. solani 1 d after inoculation, but after 3 d there was no difference in the pathogen density between soil amended with broth culture and control soil. In microcosm studies, cell suspensions of RB14-C also did not inhibit growth of R. solani on filters buried in soil. However, an inhibitory effect was obtained when a broth culture of the bacterium was used. The effect of RB14-C on fungal biomass was also estimated by measurement of ergosterol concentration in soil. It was found that ergosterol was mostly derived from R. solani and that there were no significant differences in its content between untreated soil and soil treated with RB14-C. The results suggest that suppression of Rhizoctonia damping-off by B. subtilis RB14-C probably is not related to the reduction of the pathogen population in the soil.
Metabolic profiles to define the genome: can we hear the phenotypes? (2004)

There is an increased reliance on genetically modified organisms as a functional genomic tool to elucidate the role of genes and their protein products. Despite this, many models do not express the expected phenotype thought to be associated with the gene or protein. There is thus an increased need to further define the phenotype resultant from a genetic modification to understand how the transcriptional or proteomic network may conspire to alter the expected phenotype. This is best typified by the description of the silent phenotype in genetic manipulations of yeast. High-resolution proton nuclear magnetic resonance ((1)H NMR) spectroscopy provides an ideal mechanism for the profiling of metabolites within biofluids, tissue extracts or, with recent advances, intact tissues. These metabolic datasets can be readily mined using a range of pattern recognition techniques, including hierarchical cluster analysis, principal components analysis, partial least squares and neural networks, with the combined approach being termed metabolomics. This review describes the application of NMR-based metabolomics or metabonomics to genetic and chemical interventions in a number of different species, demonstrating the versatility of such an approach, as well as suggesting how it may be integrated with other "omic" technologies.
Design of diplexers with maximally flat response and frequency symmetry (2002)

A new formulation and synthesis method for diplexers with or without finite transmission zeros with a prescribed insertion loss at the crossover frequency and with maximally flat response has been developed. The element values are synthesized by using a novel approach which is based on direct formulation of necessary equations in terms of the element values and solving the equations using numerical techniques. Also a new method for obtaining the initial estimates for the numerical solution has been introduced. The method has been successfully applied on various examples.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Low-damage silicon etching using a neutral beam (2013)

A low-damage silicon etching technology for fabricating microelectromechanical system (MEMS) devices using a neutral beam is reported. Neutral beams were produced from Cl2 plasma in an etching apparatus and were used to etch silicon trenches and MEMS devices. Si trench etch rate depended on the bias voltage applied to an aperture, used to produce the neutral beam. Etch rate decreased with increasing Si trench aspect ratio. This trend was minimized by enlarging the aspect ratio of through-holes in the aperture. The silicon trench profile was influenced by the aspect ratio of through-holes in the aperture. Etched Si surfaces were smooth, and no damage/defects were observed by transmission electron microscopy. Si etching of MEMS devices with smooth surfaces and scallop free sidewalls was achieved. The mechanical characteristics of an oscillator etched with the neutral beam were superior to those of that etched using a conventional Bosch process.
Observation of Living Organisms in Environmental Samples by Transmission-Through-Dye Microscopy (2016)

Transmission-through-dye (TTD) microscopy renders live cells bright red over a dark background. Previously TTD had been used for cell volume measurements; in this article the strong contrast generated by TTD is presented as a stand-alone merit, in particular for observation of environmental samples. Such samples often contain large amounts of detritus that can easily obscure living cells and organisms. TTD imaging allows the microscopist to circumvent this difficulty: cells with intact membranes turn bright on TTD images, whereas dead matter remains dark. This property of TTD can be valuable for observing and studying aquatic life.
Peeking behind the curtains of serverless platforms (2018)

Serverless computing is an emerging paradigm in which an application's resource provisioning and scaling are managed by third-party services. Examples include AWS Lambda, Azure Functions, and Google Cloud Functions. Behind these services' easy-to-use APIs are opaque, complex infrastructure and management ecosystems. Taking on the viewpoint of a serverless customer, we conduct the largest measurement study to date, launching more than 50,000 function instances across these three services, in order to characterize their architectures, performance, and resource management efficiency. We explain how the platforms isolate the functions of different accounts, using either virtual machines or containers, which has important security implications. We characterize performance in terms of scalability, coldstart latency, and resource efficiency, with highlights including that AWS Lambda adopts a bin-packing-like strategy to maximize VM memory utilization, that severe contention between functions can arise in AWS and Azure, and that Google had bugs that allow customers to use resources for free.
Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin (2015)

The plasticity of tumour-associated macrophages (TAMs) has implicated an influential role in hepatocellular carcinoma (HCC). Repolarisation of TAM towards M1 phenotype characterises an immune-competent microenvironment that favours tumour regression. To investigate the role and mechanism of TAM repolarisation in suppression of HCC by a natural compound baicalin, Orthotopic HCC implantation model was used to investigate the effect of baicalin on HCC; liposome-clodronate was introduced to suppress macrophage populations in mice; bone marrow-derived monocytes (BMDMs) were induced to unpolarised, M1-like, M2-like macrophages and TAM using different conditioned medium. We observed that oral administration of baicalin (50 mg/kg) completely blocked orthotopic growth of implanted HCC. Suppression of HCC by baicalin was diminished when mice macrophage was removed by clodronate treatment. Baicalin induced repolarisation of TAM to M1-like phenotype without specific toxicity to either phenotype of macrophages. Baicalin initiated TAM reprogramming to M1-like macrophage, and promoted pro-inflammatory cytokines production. Co-culturing of HCC cells with baicalin-treated TAMs resulted in reduced proliferation and motility in HCC. Baicalin had minimal effect on derivation of macrophage polarisation factors by HCC cells, while directly induced repolarisation of TAM and M2-like macrophage. This effect was associated with elevated autophagy, and transcriptional activation of RelB/p52 pathway. Suppression of autophagy or RelB abolished skewing of baicalin-treated TAM. Autophagic degradation of TRAF2 in baicalin-treated TAM might be responsible for RelB/p52 activation. Our findings unveil the essential role of TAM repolarisation in suppressive effect of baicalin on HCC, which requires autophagy-associated activation of RelB/p52.
<i>DLC1</i> is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma (2008)

Deletions on chromosome 8p are common in human tumors, suggesting that one or more tumor suppressor genes reside in this region. Deleted in Liver Cancer 1 (DLC1) encodes a Rho-GTPase activating protein and is a candidate 8p tumor suppressor. We show that DLC1 knockdown cooperates with Myc to promote hepatocellular carcinoma in mice, and that reintroduction of wild-type DLC1 into hepatoma cells with low DLC1 levels suppresses tumor growth in situ. Cells with reduced DLC1 protein contain increased GTP-bound RhoA, and enforced expression a constitutively activated RhoA allele mimics DLC1 loss in promoting hepatocellular carcinogenesis. Conversely, down-regulation of RhoA selectively inhibits tumor growth of hepatoma cells with disabled DLC1. Our data validate DLC1 as a potent tumor suppressor gene and suggest that its loss creates a dependence on the RhoA pathway that may be targeted therapeutically.
Thermal Conductivity of Dielectric Films and Correlation to Damage Threshold at 1064nm (1988)

An infrared line scanning technique has been used to measure thermal conductivities of TiO2, Ta2O5, ZrO2, HfO2, A12O3 and SiO2 layers. Damage thresholds are determined using a two stage Nd:Yag laser with pulse length of 14ns and spot size of 300μ. A correlation between thermal conductivity, absorption coefficient, melting point and damage threshold is established. To explain the relation, theoretical models based on absorption and inclusion breakdown are analysed.
Amyloid-β Toxicity and Tau Hyperphosphorylation are Linked Via RCAN1 in Alzheimer's Disease (2011)

Amyloid-β peptide (Aβ) toxicity and tau hyperphosphorylation are hallmarks of Alzheimer's disease (AD). How their molecular relationships may affect the etiology, progression, and severity of the disease, however, has not been elucidated. We now report that incubation of fetal rat cortical neurons with Aβ upregulates expression of the Regulator of Calcineurin gene RCAN1, and this is mediated by Aβ-induced oxidative stress. Calcineurin (PPP3CA) is a serine-threonine phosphatase that dephosphorylates tau. RCAN1 proteins inhibit this phosphatase activity of calcineurin. Increased expression of RCAN1 also causes upregulation of glycogen synthase kinase-3β (GSK3β), a tau kinase. Thus, increased RCAN1 expression might be expected to decrease phospho-tau dephosphorylation (via calcineurin inhibition) and increase tau phosphorylation (via increased GSK3β activity). Indeed, we find that incubation of primary cortical neurons with Aβ results in increased phosphorylation of tau, unless RCAN1 gene expression is silenced, or antioxidants are added. Thus we propose a mechanism to link Aβ toxicity and tau hyperphosphorylation in AD: In our hypothesis, Aβ causes mitochondrial oxidative stress and increases production of reactive oxygen species, which result in an upregulation of RCAN1 gene expression. RCAN1 proteins then both inhibit calcineurin and induce expression of GSK3β. Both mechanisms shift tau to a hyperphosphorylated state. We also find that lymphocytes from persons whose ApoE genotype is ε4/ε4 (with high risk of developing AD) show higher levels of RCAN1 and phospho-tau than those carrying the ApoE ε3/ε3 or ε3/ε4 genotypes. Thus upregulation of RCAN1 may be a valuable biomarker for AD risk.
Expression of UDP-glucuronosyltransferase cDNA in Saccharomyces cerevisiae as a membrane-bound and as a cytosolic form (1990)

The mouse clone UDPGTm-1 encodes a UDP-glucuronosyltransferase enzyme which was isolated from a lambda gt11 cDNA library constructed with phenobarbital-induced liver mRNA [Kimura, T., & Owens, I. S. (1987) Eur. J. Biochem. 168, 515-521]. In order to establish substrate specificity, UDPGTm-1 was inserted into the yeast vector pEVP11 and expressed in Saccharomyces cerevisiae strain AH22. Cells transformed with the expression unit pUDPGTm-1c (insert in correct orientation with respect to promoter) stably transcribe the transferase cDNA. Consistent with the presence of mRNA, pUDPGTm-1c-transformed AH22 cells synthesize a transferase protein with Mr congruent to 51,000 by Western immunoblot analysis. The membrane-bound transferase expressed in yeast in glycosylated as indicated by its enhanced electrophoretic mobility in a SDS-polyacrylamide gel following endoglycosidase H treatment and detection by Western immunoblot analysis. A survey, using 12 aglycons in an assay with microsomes from cells which express the protein, shows preferential glucuronidation of naphthol and estrone followed by p-nitrophenol. Testosterone, phenolphthalein, dihydrotestosterone, androsterone, and 4-methylumbelliferone are conjugated at an intermediate level. There is barely detectable glucuronidation of 3-hydroxy- and 9-hydroxybenzo[a]pyrene and no detectable conversion of morphine or lithocholic acid. The truncated cDNA (lacking the putative membrane-insertion signal-peptide coding sequence, but with a newly adapted translation-start codon) is ligated into pAAH5 and is expressed as a cytosolic transferase form in the protease-deficient ZA521 strain of S. cerevisiae. The Mr congruent to 51,000-52,000 is similar to that seen in microsomes from AH22 cells where the protein is presumably processed as it is inserted into the membrane.(ABSTRACT TRUNCATED AT 250 WORDS)