gebhart/patrepeval huggingface dataset:
Wide-angle lenses and image collapsing subreflectors for nontracking solar collectors (1980)

This paper presents new optical methods for the design of nontracking solar energy concentrators with acceptance angles of 60 degrees in the elevation (altitude) plane and +/-50 degrees in azimuth sectors. We have designed and constructed a two-point corrected cylindrical stepped prism lens (SPL) with 30.48-cm aperture height and F/D congruent with 1, which focuses well over the acceptance interval. Image collapsing subreflector (ICS) surfaces are synthesized that reflect the incident illumination refracted by the lens onto a small fixed absorbing area or shelf ~7.6 cm wide resulting in near maximum theoretical concentration ratios for these broad acceptance angles. Nearly 100% of the incident optical rays intercept the absorber shelf. The wide-angle and image collapsing optical properties were confirmed by laser and solar experiments. Rooftop thermal tests on a 30.5 x 30.5-cm collector section using selectively absorbing tubes with water as circulant were conducted that indicate aperture efficiencies of ~60% could be exected on large area collectors based on this design.
Transparent thin-film characterization by using differential optical sectioning interference microscopy (2007)

We propose an optical thin-film characterization technique, differential optical sectioning interference microscopy (DOSIM), for simultaneously measuring the refractive indices and thicknesses of transparent thin films with submicrometer lateral resolution. DOSIM obtains the depth and optical phase information of a thin film by using a dual-scan concept in differential optical sectioning microscopy combined with the Fabry-Perot interferometric effect and allows the solution of refractive index and thickness without the 2pi phase-wrapping ambiguity. Because DOSIM uses a microscope objective as the probe, its lateral resolution achieves the diffraction limit. As a demonstration, we measure the refractive indices and thicknesses of SiO2 thin films grown on Si substrate and indium-tin-oxide thin films grown on a glass substrate. We also compare the measurement results of DOSIM with those of a conventional ellipsometer and an atomic force microscope.
Fast Proxy Re-Encryption for Publish/Subscribe Systems. (2017)

© 2017 ACM. We develop two IND-CPA-secure multihop unidirectional Proxy Re-Encryption (PRE) schemes by applying the Ring-LWE (RLWE) key switching approach from the homomorphic encryption literature. Unidirectional PRE is ideal for secure publish-subscribe operations where a publisher encrypts information using a public key without knowing upfront who the subscriber will be and what private key will be used for decryption. The proposed PRE schemes provide a multihop capability, meaning that when PRE-encrypted information is published onto a PRE-enabled server, the server can either delegate access to specific clients or enable other servers the right to delegate access. Our first scheme (which we call NTRU-ABD-PRE) is based on a variant of the NTRU-RLWE homomorphic encryption scheme. Our second and main PRE scheme (which we call BV-PRE) is built on top of the Brakerski-Vaikuntanathan (BV) homomorphic encryption scheme and relies solely on the RLWE assumption. We present an open-source C++ implementation of both schemes and discuss several algorithmic and software optimizations. We examine parameter selection tradeoffs in the context of security, runtime/latency, throughput, ciphertext expansion, memory usage, and multihop capabilities. Our experimental analysis demonstrates that BV-PRE outperforms NTRU-ABD-PRE in both single-hop and multihop settings. The BVPRE scheme has a lower time and space complexity than existing IND-CPA-secure lattice-based PRE schemes and requires small concrete parameters, making the scheme computationally efficient for use on low-resource embedded systems while still providing 100 bits of security. We present practical recommendations for applying the PRE schemes to several use cases of ad hoc information sharing for publish-subscribe operations.
Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein–Protein Interactions (2018)

Cross-linking mass spectrometry (XL-MS) has become an emerging technology for defining protein-protein interactions (PPIs) and elucidating architectures of large protein complexes. Up to now, the most widely used cross-linking reagents target lysines. Although such reagents have been successfully applied to map PPIs at the proteome-wide scale, comprehensive PPI profiling would require additional cross-linking chemistries. Cysteine is one of the most reactive amino acids and an attractive target for cross-linking owing to its unique role in protein structures. Although sulfhydryl-reactive cross-linkers are commercially available, their applications in XL-MS studies remain sparse, likely due to the difficulty in identifying cysteine cross-linked peptides. Previously, we developed a new class of sulfoxide-containing MS-cleavable cross-linkers to enable fast and accurate identification of cross-linked peptides using multistage tandem mass spectrometry (MS <sup>n</sup>). Here, we present the development of a new sulfoxide-containing MS-cleavable homobifunctional cysteine-reactive cross-linker, bismaleimide sulfoxide (BMSO). We demonstrate that BMSO-cross-linked peptides display the same characteristic fragmentation pattern during collision-induced dissociation (CID) as other sulfoxide-containing MS-cleavable cross-linked peptides, thus permitting their simplified analysis and unambiguous identification by MS <sup>n</sup>. Additionally, we show that BMSO can complement amine- and acidic-residue-reactive reagents for mapping protein-interaction regions. Collectively, this work not only enlarges the toolbox of MS-cleavable cross-linkers with diverse chemistries, but more importantly expands our capacity and capability of studying PPIs in general.
Towards the development of APLF scintillators for neutron detection (2013)

We studied lanthanide-doped 20Al(PO3)3-80LiF, or simply APLF, as scintillator for neutron detection. Lanthanide-doped APLFs had faster fluorescence decay times by about 10 ns compared to a standard scintillator, GS2. Nd-doped APLF exhibited the fastest decay time of 6.6 ns. The fluorescence of the Pr-doped and GS2 using different radiation sources were also compared. The Pr-doped APLF had faster decay time compared to GS2 regardless of the radioactive excitation source. We demonstrated the potential of the Pr-doped APLF as a scintillator by neutron diagnostics. Lanthanide- doped APLFs can be better alternatives to conventional scintillators. We envision further developments of lanthanide-doped APLF-based neutronscintillators.
Chipless RFID Tags' Identification Algorithm by Using an Eigenmode Approach Combined with Signal-Processing Technique (2018)

A novel identification algorithm of chipless RFID tags by using an eigenmode analysis based on the SVD-decomposition, in conjunction with a signal-processing technique is presented. We start by extract a dominant eigenmode of the tag and show that we can significantly enhance the capability to carry out the scatterer recognition by exciting the tag with a transmitter antenna array with an excitation coefficient associated to the dominant mode. Later, a signal-processing algorithm is proposed to identify a tag based on the signals received by an array including fields scattered from the direct coupling between the transmitter and the receiver antennas in presence and in absence of the tag in the reader area. In addition, an identification vector is processed to detect the presence of multiple chipless tags simultaneously with range information and to identify a particular tag.
Photoinduced Thermal Polymerization Reactions (2018)

The combination of thermally induced and photoinduced free radical polymerization of (meth)acrylic monomers has only been scarcely presented in the literature. In this study, a two-component system with a near-infrared (NIR) dye combined with a thermal initiator is presented. The dye acts as a very efficient heat generator (heater) upon irradiation with NIR light. Several thermal initiators are presented such as an alkoxyamine (e.g., BlocBuilder-MA), azo derivatives, and (hydro)peroxides. The heat delivered by the dye dissociates the thermal initiator, which initiates the free radical polymerization of (meth)acrylates. Several types of heat generators are presented such as borate-based dyes and a silicon phthalocyanine derivative. For the first time, the effects of the NIR heater concentration, light intensity, and monomer structure on the heat released are studied using thermal imaging studies. NIR light curing is challenging but offers significant advantages: it is safer than shorter wavelength, and it allows a deeper penetration of the light and therefore a better curing of filled samples for a unique access to composites. Systems using a cyanine borate as a dye give high conversion rate of C═C for methacrylate monomer under air. Two wavelengths of irradiation are studied: 785 and 850 nm. The presence of additives (phosphines or iodonium salts) can also improve the polymerization profiles.
Completely Decentralized Active Balancing Battery Management System (2017)

The performance of a string of series-connected batteries is typically restricted by the worst cell in the string and a single failure point will render the entire string unusable. To address these issues, we present a decentralized battery management system with no communication requirement based on a modular multilevel converter topology with a distributed inductor and distributed controller running on a local microprocessor. This configuration is referred to as a “smart cell.” By sensing the voltage across the local distributed inductor, each smart cell is able to: first, determine its optimal switching pattern in order to minimize the output voltage ripple; and second, adjust its duty cycle to synchronize its state of charge (SOC) with the average SOC of the series string of cells. The decentralized controller is derived using the theory of Kuramoto oscillators, and the stability of a system of smart cells is investigated. We experimentally show that a system of three smart cells with their decentralized controllers can accurately synchronize the SOC while minimizing their output voltage ripple.
Purification of Nucleoside-5′-diphosphates: A New Ion-Exchange Method (1993)

Abstract Inosine- and uridine-5′-diphosphates can be purified by ion-exchange chromatography utilizing a new ion-exchange method where Type 1 ion-exchange resins and the absorbed nucleoside polyphosphates are changed to the basic form by rinsing the column with dilute sodium hydroxide and subsequently eluting with dilute hydrochloric acid and sodium chloride.
Lactoferrin: Natural - Multifunctional - Antimicrobial (2000)

PREFACE HIGHLIGHTS: ACTIVATED LACTOFERRIN SUMMARY: PROTECTING MEAT FROM HARMFUL BACTERIA QUESTIONS AND ANSWERS ABOUT THE PRINCIPAL INVESTIGATOR ABOUT THE INSTITUTION THIRD-PARTY REFERENCES EXCERPTS
A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors (2016)

Antibodies targeting the PD-1/PD-L1 immune checkpoint lead to tumor regression and improved survival in several cancers. PD-L1 expression in tumors may be predictive of response to checkpoint blockade therapy. Because tissue samples might not always be available to guide therapy, we developed and evaluated a humanized antibody for non-invasive imaging of PD-L1 expression in tumors. Radiolabeled [111In]PD-L1-mAb and near-infrared dye conjugated NIR-PD-L1-mAb imaging agents were developed using the mouse and human cross-reactive PD-L1 antibody MPDL3280A. We tested specificity of [111In]PD-L1-mAb and NIR-PD-L1-mAb in cell lines and in tumors with varying levels of PD-L1 expression. We performed SPECT/CT imaging, biodistribution and blocking studies in NSG mice bearing tumors with constitutive PD-L1 expression (CHO-PDL1) and in controls (CHO). Results were confirmed in triple negative breast cancer (TNBC) (MDAMB231 and SUM149) and non-small cell lung cancer (NSCLC) (H2444 and H1155) xenografts with varying levels of PD-L1 expression. There was specific binding of [111In]PD-L1-mAb and NIR-PD-L1-mAb to tumor cells in vitro, correlating with PD-L1 expression levels. In mice bearing subcutaneous and orthotopic tumors, there was specific and persistent high accumulation of signal intensity in PD-L1 positive tumors (CHO-PDL1, MDAMB231, H2444) but not in controls. These results demonstrate that [111In]PD-L1-mAb and NIR-PD-L1-mAb can detect graded levels of PD-L1 expression in human tumor xenografts in vivo. As a humanized antibody, these findings suggest clinical translation of radiolabeled versions of MPDL3280A for imaging. Specificity of NIR-PD-L1-mAb indicates the potential for optical imaging of PD-L1 expression in tumors in relevant pre-clinical as well as clinical settings.
Magnetic resonance spectroscopy of an atomically thin material using a single-spin qubit (2017)

Two-dimensional (2D) materials offer a promising platform for exploring condensed matter phenomena and developing technological applications. However, the reduction of material dimensions to the atomic scale poses a challenge for traditional measurement and interfacing techniques that typically couple to macroscopic observables. We demonstrate a method for probing the properties of 2D materials via nanometer-scale nuclear quadrupole resonance (NQR) spectroscopy using individual atomlike impurities in diamond. Coherent manipulation of shallow nitrogen-vacancy (NV) color centers enables the probing of nanoscale ensembles down to approximately 30 nuclear spins in atomically thin hexagonal boron nitride (h-BN). The characterization of low-dimensional nanoscale materials could enable the development of new quantum hybrid systems, combining atomlike systems coherently coupled with individual atoms in 2D materials.
N-[2-(4-Methylphenyl)Ethyl]-N′-[2-(5-Bromopyridyl)]-Thiourea as a Potent Inhibitor of NNRTI-Resistant and Multidrug-Resistant Human Immunodeficiency Virus Type 1 (2000)

The composite non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket model was used to study a number of thiourea analogues with different substitutions at the 4-phenyl position including N-[2-(4-methylphenyl)ethyl]-N′-[2-(5-bromopyridyl)]-thiourea (compound HI-244), which inhibited recombinant RT better than trovirdine or compound HI-275 with an unsubstituted phenyl ring. HI-244 effectively inhibited the replication of HIV-1 strain HTLV IIIB in human peripheral blood mononuclear cells with an IC 50 value of 0.007 μM, which is equal to the IC 50 value of trovirdine. Notably, HI-244 was 20 times more effective than trovirdine against the multidrug-resistant HIV-1 strain RT-MDR with a V106A mutation (as well as additional mutations involving the RT residues 74 V, 41L and 215Y) and seven times more potent than trovirdine against the NNRTI- resistant HIV-1 strain A17 with a Y181C mutation.
Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill (2015)

Despite having a modest predictive value for infection independent of source, IL-27 may serve as a useful biomarker in estimating risk of bacterial infection among critically ill pediatric patients with bloodstream infections. In particular, among immunocompromised subjects, this diagnostic biomarker may be helpful either alone or using a combination strategy with other available biomarkers.
Pain assessment in infants: Towards spotting pain expression based on infants' facial strain (2015)

We report novel results of utilizing infant facial tissue distortion as a pain indicator in video-sequences of ten infants based on analysis of facial strain. Facial strain, which is used as the main feature for classification, is generated for each facial expression and then used to train two classifiers, k Nearest-Neighbors (KNN) and support vector machine (SVM) to classify infants' expressions into two categories, pain and no-pain. The accuracy of binary classification for KNN and SVM was 96% and 94% respectively, based on ten video sequences. The results of this study are encouraging; they indicate that assessing pain based on facial displays is a promising area of investigation, and open new directions for future work.
WE‐DE‐201‐08: Multi‐Source Rotating Shield Brachytherapy Apparatus for Prostate Cancer (2016)

Purpose: To introduce a novel multi‐source rotating shield brachytherapy (RSBT) apparatus for the precise simultaneous angular and linear positioning of all partially‐shielded 153Gd radiation sources in interstitial needles for treating prostate cancer. The mechanism is designed to lower the detrimental dose to healthy tissues, the urethra in particular, relative to conventional high‐dose‐rate brachytherapy (HDR‐BT) techniques. Methods: Following needle implantation, the delivery system is docked to the patient template. Each needle is coupled to a multi‐source afterloader catheter by a connector passing through a shaft. The shafts are rotated by translating a moving template between two stationary templates. Shaft walls as well as moving template holes are threaded such that the resistive friction produced between the two parts exerts enough force on the shafts to bring about the rotation. Rotation of the shaft is then transmitted to the shielded source via several keys. Thus, shaft angular position is fully correlated with the position of the moving template. The catheter angles are simultaneously incremented throughout treatment as needed, and only a single 360° rotation of all catheters is needed for a full treatment. For each rotation angle, source depth in each needle is controlled by a multi‐source afterloader, which is proposed as an array of belt‐driven linear actuators, each of which drives a source wire. Results: Optimized treatment plans based on Monte Carlo dose calculations demonstrated RSBT with the proposed apparatus reduced urethral D 1cc below that of conventional HDR‐BT by 35% for urethral dose gradient volume within 3 mm of the urethra surface. Treatment time to deliver 20 Gy with multi‐source RSBT apparatus using nineteen 62.4 GBq 153 Gd sources is 117 min. Conclusions: The proposed RSBT delivery apparatus in conjunction with multiple nitinol catheter‐mounted platinum‐shielded 153 Gd sources enables a mechanically feasible urethra‐sparing treatment technique for prostate cancer in a clinically reasonable timeframe.
Pulse dynamics of a passively mode-locked Bi-doped fiber laser (2010)

The pulse evolution in Bi-doped soliton fiber laser with slow and fast saturable absorber has been studied both experimentally and numerically. Semiconductor saturable absorbers with balanced slow and fast absorption recovery mechanisms exhibit a bi-temporal recovery dynamics which permits both reliable start-up of passive mode-locking and short pulse generation and stabilization. The pulse dynamics within the Bi fiber laser cavity have been investigated.
Routing restorable bandwidth guaranteed connections using maximum 2-route flows (2003)

Routing with service restorability is very important in multiprotocol label switched (MPLS) networks, and is a necessity in optical networks. For restoration, each connection has an active path and a disjoint backup path. The backup path enables service restoration upon active path failure. For bandwidth efficiency, backups may be shared. This requires that at least the aggregate backup bandwidth used on each link be distributed to nodes performing route computations. If this information is not available, sharing is not possible. Also, one scheme in use for restorability in optical networks is for the sender to transmit simultaneously on the two disjoint paths and for the receiver to choose data from the path with stronger signal. This has the advantage of fast receiver-initiated recovery upon failure but it does not allow backup sharing. We consider the problem of efficient dynamic routing of restorable connections when backup sharing is not allowed. Our objective is to be able to route as many connections as possible for one-at-a-time arrivals and no knowledge of future arrivals. Since sharing cannot be used for achieving efficiency, the goal is to achieve efficiency by improved path selection. We show that by using the minimum-interference ideas used for non-restorable routing, we can develop efficient algorithms that outperform previously proposed algorithms for restorable routing such as routing with the min-hop like objective of finding two disjoint paths with minimum total hop-count. We present two new and efficient algorithms for restorable routing without sharing, and one of them requires only shortest path computations. We demonstrate that both algorithms perform very well in comparison to previously proposed algorithms.
Open‐tubular capillary electrochromatography/electrospray ionization‐mass spectrometry using polymeric surfactant as a stationary phase coating (2004)

We describe the use of the polymeric surfactant poly(sodium undecylenic sulfate) (poly-SUS) as a stationary phase coating in open-tubular capillary electrochromatography (OT-CEC) coupled with electrospray ionization-mass spectrometry (ESI-MS) for the analysis of beta-blocker and benzodiazepine analytes. The production of a polymeric surfactant coating on the capillary inner wall involves (i) adsorption of the cationic polymer poly(diallyldimethylammonium chloride) (PDADMAC) to the inner surface of capillary, and (ii) adsorption of the negatively charged poly-SUS onto the cationic polymer layer via strong physical interaction of the two polymer layers. As compared with micellar electrokinetic chromatography (MEKC) coupled with ESI-MS, the main advantage of this proposed method is minimization of introduction of the monomeric or polymeric surfactant into the mass spectrometer, thus avoiding the interference of the nonvolatile micelle in ESI-MS. The effects of buffer pH and applied voltage on the separation of the analytes are also discussed. Under optimum conditions, four of the five beta-blockers and four benzodiazepines are separated.
Synergistic Uric Acid‐Lowering Effects of the Combination of <i>Chrysanthemum indicum</i> Linne Flower and <i>Cinnamomum cassia</i> (L.) J. Persl Bark Extracts (2017)

<i>Chrysanthemum indicum</i> Linne flower (CF) and <i>Cinnamomum cassia</i> (L.) J. Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine. However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia. In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats. The CC mixture significantly decreased uric acid levels in normal and PO-induced hyperuricemic rats and showed the enhanced hypouricemic effect compared to CF or CB alone. Furthermore, the CC mixture increased renal uric acid excretion in PO-induced hyperuricemic rat. We found that CC mixture and its major components, chlorogenic acid, 3,4-dicaffeoylquinic acid (isochlorogenic acid), coumarin, cinnamaldehyde, <i>trans</i>-cinnamic acid, and <i>o</i>-methoxycinnamaldehyde, inhibit the activity of xanthine oxidase (XOD) in vitro. The CC mixture exerts antihyperuricemic effects accompanied partially by XOD activity inhibition. Therefore, the CC mixture may have potential as a treatment for hyperuricemia and gout.