gebhart/patrepeval huggingface dataset:
Design and Implementation of ARINC615 Protocol Software Based on AFDX (2012)

ARINC615 protocol defines a data transfer method based on ARINC429 protocol,but in the avionics networks using AFDX as the backbone network,the data loader is usually based on AFDX to accomplish data transfer function.To accomplish the data transfer from data loader based on AFDX to ARINC429 bus devices,this paper introduces a data transfer architecture based on AFDX protocol,accomplishes the functions of ARINC615 protocol with finite state machine mechanism,and designs and implements an application software based on ARINC615 protocol,ensuring the reliability and validity of file transmission.
Temperature stability of SAW on langasite single crystals (2002)

The propagation characteristics of surface acoustic waves (SAW) on La/sub 3/Ga/sub 5/SiO/sub 14/ were investigated by both numerical and experimental methods. The SAW velocity, the coupling coefficient (k/sup 2/) and the temperature coefficient of delay (TCD) on X-cut, Y-cut and 50/spl deg/ rotated Y-cut substrates were investigated numerically. Then SAW properties were measured using transversal filters of different propagation directions on these cuts. The experimental results of the SAW velocity and the k/sup 2/ were in good agreement with the numerical results. However, except for some cuts, TCD in experiment differed from that of numerical calculations. The propagation direction and the electrode thickness dependence of the turnover temperature was investigated on the 50/spl deg/ rotated Y-cut substrate.
A Strand-Specific RNA–Seq Analysis of the Transcriptome of the Typhoid Bacillus Salmonella Typhi (2009)

High-density, strand-specific cDNA sequencing (ssRNA-seq) was used to analyze the transcriptome of Salmonella enterica serovar Typhi (S. Typhi). By mapping sequence data to the entire S. Typhi genome, we analyzed the transcriptome in a strand-specific manner and further defined transcribed regions encoded within prophages, pseudogenes, previously un-annotated, and 3'- or 5'-untranslated regions (UTR). An additional 40 novel candidate non-coding RNAs were identified beyond those previously annotated. Proteomic analysis was combined with transcriptome data to confirm and refine the annotation of a number of hpothetical genes. ssRNA-seq was also combined with microarray and proteome analysis to further define the S. Typhi OmpR regulon and identify novel OmpR regulated transcripts. Thus, ssRNA-seq provides a novel and powerful approach to the characterization of the bacterial transcriptome.
Low on-resistance power LDMOSFET using double metal process technology (2002)

A low on-resistance lateral power FET which is suitable for the H-bridge motorcontrol IPD (intelligent power device) for automatic applications is described. The LDMOSFET was fabricated using the double metal process technology with a hexagonal pattern layout which increases the cell density. The device with cell density as high as 5.1 million cells/in/sup 2/ has a specific on-resistance of 1.15 m Omega -cm/sup 2/ under pulsed drain bias conditions, and the reverse blocking voltage is 42 V. This on-resistance represents the lowest among the lateral type power FETs with similar blocking voltage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Peripheral Administration of Antisense Oligonucleotides Targeting the Amyloid-β Protein Precursor Reverses AβPP and LRP-1 Overexpression in the Aged SAMP8 Mouse Brain (2012)

The senescence accelerated mouse-prone 8 (SAMP8) mouse model of Alzheimer's disease has a natural mutation leading to age-related increases in the amyloid-β protein precursor (AβPP) and amyloid-β (Aβ) in the brain, memory impairment, and deficits in Aβ removal from the brain. Previous studies show that centrally administered antisense oligonucleotide directed against AβPP can decrease AβPP expression and Aβ production in the brains of aged SAMP8 mice, and improve memory. The same antisense crosses the blood-brain barrier and reverses memory deficits when injected intravenously. Here, we give 6 μg of AβPP or control antisense 3 times over 2 week intervals to 12 month old SAMP8 mice. Object recognition test was done 48 hours later, followed by removal of whole brains for immunoblot analysis of AβPP, low-density lipoprotein-related protein-1 (LRP-1), p-glycoprotein (Pgp), receptor for advanced glycation endproducts (RAGE), or ELISA of soluble Aβ(40). Our results show that AβPP antisense completely reverses a 30% age-associated increase in AβPP signal (p < 0.05 versus untreated 4 month old SAMP8). Soluble Aβ(40) increased with age, but was not reversed by antisense. LRP-1 large and small subunits increased significantly with age (147.7%, p < 0.01 and 123.7%, p < 0.05 respectively), and AβPP antisense completely reversed these increases (p < 0.05). Pgp and RAGE were not significantly altered with age or antisense. Antisense also caused improvements in memory (p < 0.001). Together, these data support the therapeutic potential of AβPP antisense and show a unique association between AβPP and LRP-1 expression in the SAMP8 mouse.
A Silicon-Polymer Hybrid Modulator—Design, Simulation and Proof of Principle (2013)

Optimal dimensions are found for the silicon waveguide in an electro-optic (EO) polymer cladding-based silicon waveguide modulator. The confinement factor as well as the effective index of the mode are taken into account. The influence of the coplanar electrode spacing and electrode height on performance are examined and a figure of merit formula for choosing the optimal device geometry is shown. The design space for both 1550 nm and 1310 nm wavelengths is explored. With the optimal 275 nm waveguide width and 4 μm electrode spacing, a Vπ of a few volts can be achieved even with moderate r33 EO polymers. Experimental results on a fabricated modulator are shown and compared with the predicted performance.
Electrically Tunable Surface Plasmon Source for THz Applications (2010)

In this paper, we propose a design for a widely tunable solid-state optically and electrically pumped terahertz source based on the Smith-Purcell free-electron laser. Our design consists of a thin dielectric layer sandwiched between an upper corrugated structure and a lower layer of thin metal, semiconductor, or high-electron-mobility material. The lower layer is for current streaming, which replaces the electron beam in the Smith-Purcell free-electron laser design. The upper layer consists of two microgratings for optical pumping, and a nanograting to couple with electrical pumping in the lower layer. The optically generated surface plasmon waves from the upper layer and the electrically induced surface plasmon waves from the lower layer are then coupled. Emission enhancement occurs when the plasmonic waves in both layers are resonantly coupled.
Malaria research trends (2007)

Preface Malaria Resistance or Susceptibility in Red Cell Disorders An Evaluation of Malaria During Pregnancy and its Association with Maternal Anemia, HIV Infection, ABO Blood Group and Haemoglobin Genotype in South Eastern Nigeria Anti-malarial and Toxic Effects of Four African Medicinal used for the Treatment of Malaria in the Democratic Republic of Congo Malaria Control and the Domestic Context: The Influence of Human Behaviour on the Effectiveness of Insecticide Treated Nets use (ITNS) in Northern Ghana Global Environmental Change and Malaria: Some Predictions based on a Multi-Compartment System Dynamics Model Perturbations in Serum Protein Profile in Adult Patients presenting with Acute, Uncomplicated Falciparum Malaria Infection Clinical Geography of Malaria A Comparative Study of Haematological Parameters in Children with and without Plasmodium Falciparum Gametocytes Index.
A Multidisciplinary Design Optimization Framework for Design Studies of an Efficient Supersonic Air Vehicle (2012)

A modular multidisciplinary analysis and optimization framework tool has been built with the goal of optimally designing a supersonic aircraft. This paper addresses the specic challenge of designing an ecient long range supersonic bomber aircraft. This framework includes all the disciplines normally required for supersonic aircraft design and it also includes disciplines specically required by an advanced military aircraft that is tailless and has embedded engines. Results from running the analysis framework for a B-58 supersonic bomber test case are presented as a validation of the methods employed.
Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis (2010)

Tunicamycin, a potent reversible translocase I inhibitor, is produced by several Actinomycetes species. The tunicamycin structure is highly unusual, and contains an 11-carbon dialdose sugar and an α, β-1″,11'-glycosidic linkage. Here we report the identification of a gene cluster essential for tunicamycin biosynthesis by high-throughput heterologous expression (HHE) strategy combined with a bioassay. Introduction of the genes into heterologous non-producing Streptomyces hosts results in production of tunicamycin by these strains, demonstrating the role of the genes for the biosynthesis of tunicamycins. Gene disruption experiments coupled with bioinformatic analysis revealed that the tunicamycin gene cluster is minimally composed of 12 genes (tunA-tunL). Amongst these is a putative radical SAM enzyme (Tun B) with a potentially unique role in biosynthetic carbon-carbon bond formation. Hence, a seven-step novel pathway is proposed for tunicamycin biosynthesis. Moreover, two gene clusters for the potential biosynthesis of tunicamycin-like antibiotics were also identified in Streptomyces clavuligerus ATCC 27064 and Actinosynnema mirums DSM 43827. These data provide clarification of the novel mechanisms for tunicamycin biosynthesis, and for the generation of new-designer tunicamycin analogs with selective/enhanced bioactivity via combinatorial biosynthesis strategies.
Exploring Variety in Digital Collections and the Implications for Digital Preservation (2005)

The amount of digital content produced at academic research institutions is large, and libraries and archives at these institutions have a responsibility to bring this digital material under curatorial control in order to manage and preserve it over time. But this is a daunting task with few proven models, requiring new technology, policies, procedures, core staff competencies, and cost models. The MIT Libraries are working with the DSpace™ open-source digital repository platform to explore the problem of capturing research and teaching material in any digital format and preserving it over time. By collaborating on this problem with other research institutions using the DSpace platform in the United States, the United Kingdom, Europe, and other parts of the world, as well as with other important efforts in the digital preservation arena, we are beginning to see ways of managing arbitrary digital content that might make digital preservation an achievable goal.
Explainable AI based Interventions for Pre-season Decision Making in Fashion Retail (2020)

Future of sustainable fashion lies in adoption of AI for a better understanding of consumer shopping behaviour and using this understanding to further optimize product design, development and sourcing to finally reduce the probability of overproducing inventory. Explainability and interpretability are highly effective in increasing the adoption of AI based tools in creative domains like fashion. In a fashion house, stakeholders like buyers, merchandisers and financial planners have a more quantitative approach towards decision making with primary goals of high sales and reduced dead inventory. Whereas, designers have a more intuitive approach based on observing market trends, social media and runways shows. Our goal is to build an explainable new product forecasting tool with capabilities of interventional analysis such that all the stakeholders (with competing goals) can participate in collaborative decision making process of new product design, development and launch.
Candle-Flame-Like Stenosis Carotid Lesion (2020)

An 87-year-old male retired lawyer who came to our outpatient clinic and reported expressive aphasia, weakness in the right upper extremity, and inability to write as normal. Symptoms were highly suggestive of TIAs. On physical examination, he had a loud left carotid bruit. Carotid Doppler suggested a high-grade lesion of left common Carotid Artery. Carotid angiogram showed a severe candle-flame-like narrowing in the left common carotid artery that extended to the bulb area with post stenotic dilatation (Panel A). The patient underwent successful left carotid endarterectomy with no complications and no recurrence of TIAs symptoms on further follow-up
Developmental patterning of glutamatergic synapses onto retinal ganglion cells (2008)

The spatial pattern of glutamatergic inputs onto RGCs arises early in synaptogenesis despite ensuing reorganization of dendritic structure. We raise the possibility that these early patterns of synaptic distributions may arise from constraints placed on the number of contacts presynaptic neurons are able to make with the RGCs.
Eficiencia energértica de los edificios construidos con hormigón (2007)

La mayor fuente de emisiones de gases de efecto invernadero de la Union Europea es, actualmente, la asociada a la produccion de la energia que se consume en los edificios durante su utilizacion por los usuarios de los mismos. La mayor parte de los gases de efecto invernadero emitidos son dioxido de carbono (CO2) y la mayor parte de la energia que consumen los edificios se dedica a la calefaccion y refrigeracion de los mismos (el 56% de la energia total consumida). Esta es la situacion actual motivada por el tipo de edificios que, de forma mayoritaria, se construyen y del tipo de energia que, tambien de forma mayoritaria se produce para el consumo urbano y domestico.

Es evidente que un incremento de las energias renovables mejorara la situacion, pero, con el conocimiento que hoy se tiene sobre el particular, parece que sera un proceso lento y con una incidencia moderada. Por tanto es inevitable avanzar en la construccion de un tipo de edificios mas eficientes, que funcionen con un menor consumo de energia, que los que actualmente se construyen.
Specificity of a Monoclonal Antibody for Alkaline Phosphatase in Escherichia coli and Shigella Species (1988)

The specificity of monoclonal antibody 2E5 for the alkaline phosphatase of Escherichia coli was studied against the alkaline phosphatases of 251 other bacterial strains. The organisms used included members of the six species of the genus Escherichia (E. coli, E. fergusonii, E. hermannii, E. blattae, E. vulneris, E. adecarboxylata), 41 species representing the family Enterobacteriaceae, and, in addition, Pseudomonas aeruginosa, Aeromonas spp., Plesiomonas shigelloides, Acinetobacter calcoaceticus, and Vibrio cholerae non-01. Three methods were used. An enzyme-linked immunosorbent assay was performed against 2IU of alkaline phosphatase per ml; immunofluorescence against bacterial cells and Western blotting against periplasmic proteins were also used. All of our experiments demonstrated the high specificity of monoclonal antibody 2E5. This antibody recognized only E. coli (118 strains tested) and the four species of the genus Shigella (S. sonnei, S. flexneri, S. boydii, S. dysenteriae; 12 strains tested).
Distributed tracking in a large-scale network of smart cameras (2010)

This paper describes a new distributed algorithm for tracking in distributed camera networks. This algorithm operates without a centralized server that collects all the measurements over the entire network. With the observations sent from its neighbors and the local probabilistic transition model, each camera independently estimates local paths in its neighborhood. The conflicts on locally estimated paths among cameras are resolved by a voting algorithm, and the agreed local paths are finally combined into global paths. Our experiments with simulated data demonstrate that the proposed distributed tracking algorithm is fast and scalable without degrading tracking accuracy.
Increase in Lipid Content in Potato Tubers Modified by 14-3-3 Gene Overexpression (2001)

Recently, transgenic potato plants were created with overexpression of the 14-3-3 protein derived from Cucurbita pepo. Detailed analysis of those plants suggested that the function of the isolated 14-3-3 isoform is in the control of carbohydrate and lipid metabolism in the plants. 14-3-3 protein overexpression gave rise to an increase in soluble sugar and catecholamine contents in both leaves and tubers. It is proposed that 14-3-3 protein affects carbohydrate metabolism in potato plants via regulation of catecholamine synthesis. Furthermore, genetically modified potato tubers with 14-3-3 protein overexpression showed changes in lipid content and composition. The transgenic potato tubers contained 69% more total fat compared to the wild-type plant. Separation of tuber lipids into polar and nonpolar fractions revealed that the transgenic potato tubers contained almost 3 times more nonpolar lipids than the control. Analysis of fatty acid composition, conducted by the means of gas chromatography, showed that linoleic acid was the main fatty acid present in the tubers of both modified and control potato plants. In the nonpolar fraction of the fat of the transgenic tubers the unsaturated fatty acids exhibited a higher participation in the sum of all fatty acids.
Chromosome translocations: good genes gone wrong. (1995)

Cytogenetic analysis of tumor cells has revealed that recurring chromosome abnormalities are present in many tumors. In the leukemias, lymphomas, sarcomas, these abnormalities are frequently translocations or less often inversions which are closely associated with particular morphologic subtypes of these tumors. Rearrangements involving chromosome band 11q23 are common in acute leukemia, both lymphoblastic and myeloid (monoblastic), and are less common in lymphoma. Although several different genes have been cloned from 11q23 translocation breakpoints, the great majority involve the MLL (myeloid-lymphoid leukemia) gene. The MLL gene has several different names, ALL1, Htrx, HRX; the central part of the gene codes for multiple zinc fingers which show homology to the Drosophila trithorax gene. About 70% of infants with acute leukemia will have MLL rearrangements. MLL is involved in five common translocations as well as in 25 uncommon or rare translocations, insertions and deletions. The translocation breakpoints occur within an 8.3 kb region which can be detected with a 0.74 kb cDNA probe. Twenty-five percent of patients have a deletion 3' of the breakpoint which includes the zinc finger region. Patients who previously received drugs that inhibit topoisomerase II often develop acute leukemia with translocations involving 11q23. These translocations break MLL in the same 8.3 kb region. In the breakpoints cloned to date, the translocation leads to a fusion gene on the derivative 11 chromosome with a chimeric transcript, consisting of 5' MLL and the 3' segment of the other gene. The molecular dissection of these arrangements will provide insights into the biology of MLL and into the interaction of MLL with topoisomerase II inhibitors.(ABSTRACT TRUNCATED AT 250 WORDS)
[On-line monitoring of oxygen uptake rate and its application in hybridoma culture]. (2003)

On-line analysis and control are critical for the optimization of product yields in animal cell culture. The close monitor of viable cell number helps to gain a better insight into the metabolism and to refine culture strategy. In this study, we use the oxygen uptake rate (OUR) to estimate the number of viable cell and the OUR-based feed-back control strategy for nutrients feeding to improve the efficiency of cell culture. A hybridoma cell line (HAb18) was cultured in fed-batch and perfusion model using serum free medium in 5L CelliGen Plus bioreactor (NBS Co., American) and 5L Biostat B bioreactor (Braun Co., Germany). The system and the method for online monitoring OUR in bioreactors, based on the dynamic measurement of dissolved oxygen (DO), were developed. The method of on-line cell concentration estimation was established based on the relationship between the growth of the hybridoma and the uptake rate of oxygen. This method was then used to determine OUR and the concentrations of cell, antibody, glucose, lactate, glutamine and ammonia in the bioreactors at given times. The relationship between OUR and nutrients metabolism was studied and OUR-based feed-back control strategy, which used the state deltaOUR = 0 as the regulation point, was established and used to control the rates of nutrients or medium feeding rate in the perfusion culture. The results showed that there was close relationship between OUR, concentration of live cells, productivity of antibody and consumption of glutamine. The sudden decrease in OUR may be caused by glutamine depletion, and with different delay times, the viable cell concentration and antibody productivity also decreased. The further analysis revealed the linear relationship between OUR and the density of live cells in the exponential growth phase as qOUR = (0.103 +/- 0.028) x 10(-12) mol/cell/h. These findings can be applied to the on-line detection of live cell density. Our study also indicated that by adjusting the perfusion rate with OUR-based feed-back control strategy, it is feasible to continuously increase in viable cell density and antibody concentration in the perfusion culture.
Envelope tracking technique with bang-bang slew-rate enhancer for linear wideband RF PAs (2013)

This paper deals with the design of power efficient switching regulators intended for linear power amplifiers employing envelope tracking techniques in wideband wireless standards. The bottlenecks in existing envelope tracking solutions involve a tradeoff between ripple voltage, slew rate and bandwidth. The slew rate limitation is identified as the main challenge and a `bang-bang' slew-enhancement technique is proposed for overcoming it. This approach enables the use of efficient supply modulators in wideband power amplifiers. The proposed scheme does not significantly degrade PA efficiency and improves the stability of the switching regulator. The prototype has been implemented using the TSMC 0.18 μm technology; schematic simulation results in Cadence <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> demonstrate the feasibility of the proposed technique.
USE OF FUNDUS AUTOFLUORESCENCE IMAGES TO PREDICT GEOGRAPHIC ATROPHY PROGRESSION (2010)

A simple categorical scheme that stratifies the amount of increased autofluorescence in the 500-μm margin bordering GA may be used to differentiate faster and slower progressors.