gebhart/patrepeval huggingface dataset:
Assessment of Molecular Imaging of Angiogenesis with Three-Dimensional Ultrasonography (2020)

Molecular imaging (MI) with ultrasound relies on microbubble contrast agents (MCAs) adhering to a ligand-specific target for applications such as characterizing tumor angiogenesis. It is projected that ultrasonic (US) MI can provide information about tumor therapeutic response before the detection of phenotypic changes. One of the limitations of preclinical US MI is that it lacks a comprehensive field-of-view. We attempt to improve targeted MCA visualization and quantification by performing 3-D MI of tumors expressing αvβ3. Volumetric acquisitions were obtained with a Siemens Sequoia system in CPS mode by mechanically stepping the transducer elevationally across the tumor in 800 micron increments. MI was performed on rat fibrosarcoma tumors (n=8) of similar sizes using MCAs conjugated with a cyclic RGD peptide targeted to αvβ3. US MI and immunohistochemical analyses show high microbubble targeting variability, suggesting that individual 2-D acquisitions risk misrepresenting more complex heterogeneous tissues. In 2-D serial studies, where it may be challenging to image the same plane repeatedly, misalignments as small as 800 microns can introduce substantial error. 3-D MI, including volumetric analysis of inter- and intra-animal targeting, provides a thorough way of characterizing angiogenesis and will be a more robust assessment technique for the future of MI.
Distributed delay and sum beamformer for speech enhancement in wireless sensor networks via randomized gossip (2012)

In this paper, we describe a distributed delay and sum beamformer (DDSB) for speech enhancement based on a randomized gossip algorithm. The proposed algorithm operates in a randomly connected wireless sensor network. Without any network topology constraint, the DDSB estimates the desired signal at each node by only exchanging information with its neighbors. Since the DDSB performs only local signal processing, it is robust and scalable for large sensor networks and dynamic environments. We show that the DDSB converges to the optimal estimate of the centralized beamformer. Furthermore, we provide a bound for the worst-case averaging time of the DDSB for the worst connected network. The simulation results validate the theoretical results of the algorithm.
Prostaglandin Endoperoxide H Synthase-1 (2001)

Prostaglandin endoperoxide H synthases (PGHSs) catalyze the committed step in the biosynthesis of prostaglandins and thromboxane, the conversion of arachidonic acid, two molecules of O(2), and two electrons to prostaglandin endoperoxide H(2) (PGH(2)). Formation of PGH(2) involves an initial oxygenation of arachidonate to yield PGG(2) catalyzed by the cyclooxygenase activity of the enzyme and then a reduction of the 15-hydroperoxyl group of PGG(2) to form PGH(2) catalyzed by the peroxidase activity. The cyclooxygenase active site is a hydrophobic channel that protrudes from the membrane binding domain into the core of the globular domain of PGHS. In the crystal structure of Co(3+)-heme ovine PGHS-1 complexed with arachidonic acid, 19 cyclooxygenase active site residues are predicted to make a total of 50 contacts with the substrate (Malkowski, M. G, Ginell, S., Smith, W. L., and Garavito, R. M. (2000) Science 289, 1933-1937); two of these are hydrophilic, and 48 involve hydrophobic interactions. We performed mutational analyses to determine the roles of 14 of these residues and 4 other closely neighboring residues in arachidonate binding and oxygenation. Mutants were analyzed for peroxidase and cyclooxygenase activity, and the products formed by various mutants were characterized. Overall, the results indicate that cyclooxygenase active site residues of PGHS-1 fall into five functional categories as follows: (a) residues directly involved in hydrogen abstraction from C-13 of arachidonate (Tyr-385); (b) residues essential for positioning C-13 of arachidonate for hydrogen abstraction (Gly-533 and Tyr-348); (c) residues critical for high affinity arachidonate binding (Arg-120); (d) residues critical for positioning arachidonate in a conformation so that when hydrogen abstraction does occur the molecule is optimally arranged to yield PGG(2) versus monohydroperoxy acid products (Val-349, Trp-387, and Leu-534); and (e) all other active site residues, which individually make less but measurable contributions to optimal catalytic efficiency.
A vacuum manifold for rapid world-to-chip connectivity of complex PDMS microdevices (2009)

The lack of simple interfaces for microfluidic devices with a large number of inlets significantly limits production and utilization of these devices. In this article, we describe the fabrication of a reusable manifold that provides rapid world-to-chip connectivity. A vacuum network milled into a rigid manifold holds microdevices and prevents leakage of fluids injected into the device from ports in the manifold. A number of different manifold designs were explored, and all performed similarly, yielding an average of 100 kPa (15 psi) fluid holding pressure. The wide applicability of this manifold concept is demonstrated by interfacing with a 51-inlet microfluidic chip containing 144 chambers and hundreds of embedded pneumatic valves. Due to the speed of connectivity, the manifolds are ideal for rapid prototyping and are well suited to serve as "universal" interfaces.
Impact of an infection control program in a specialized preschool (1996)

This study demonstrates a decrease in infection rates with the implementation of a comprehensive educational and environmental infection control program in a day care setting.
Is alveolar carbon monoxide an unreliable index of carboxyhaemoglobin changes during smoking in man? (1988)

1. We measured alveolar carbon monoxide (CO) after a 20 s breath-holding period and carboxyhaemoglobin both before and after smoking a cigarette on 500 occasions (101 individuals). The two measurements were closely correlated but there was a marked difference in the change or 'boost' after smoking one cigarette. The mean relative boosts ([post value--pre value]/[pre+post]/2) for alveolar CO and carboxyhaemoglobin were 7.7% and 20.3%, while negative boosts (fall rather than the expected rise) were seen in 103 of 500 and three of 500 occasions respectively. In 140 studies a third alveolar CO reading taken 5 min later was slightly larger, but the difference was insignificant. 2. In seven subjects where the carboxyhaemoglobin level was raised by breathing a 2% CO gas mixture, the alveolar CO and carboxyhaemoglobin boosts were similar (71.7% and 75.2% respectively), and they fell sharply subsequently rather than increasing further as occurred after smoking. 3. We conclude that alveolar CO measurements give a useful estimate of carboxyhaemoglobin level if the subject has not smoked for at least half an hour but that measurements of alveolar CO boost are useless since the act of smoking interferes with alveolar sampling. We postulate that cigarette smoking induces a transient change in pulmonary gas exchange.
[Lipid peroxidation and change in the lipid fraction of plasma in patients with hypertonic disease]. (1991)

Effect of lipid peroxidation on content and composition of blood plasma lipids was studied in 20 patients with hypertension within various periods after hypertonic crisis. Alterations in blood plasma lipid spectrum were shown to be related to initiation of lipid peroxidation in cell membranes. Dynamics of lipid peroxidation in individual blood plasma lipid fractions appears to reflect the adaptation under conditions of the pathological state of the organism.
Mucin Characteristics of Human Corneal-Limbal Epithelial Cells that Exclude the Rose Bengal Anionic Dye (2005)

These results indicate that stratification and differentiation of corneal epithelial cells, as measured by the capacity to produce the membrane-associated mucin MUC16 and the mucin-associated T-antigen carbohydrate on their apical surfaces provide protection against rose bengal penetrance in vitro and suggest a role for membrane-associated mucins and their oligosaccharides in the protection of ocular surface epithelia.
Cell‐penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients (2000)

Bcr-Abl contributes prominently to the development of most chronic myeloid leukemias (CMLs). Prior work has identified the adapter protein CRKL as a major substrate of the Bcr-Abl tyrosine kinase. CRKL can also bind via its first SH3 domain [SH3(1)] to specific sequences in Bcr-Abl. Cell-penetrating peptides were developed that bind with high affinity and selectivity to the SH3(1) domain of CRKL. They disrupt Bcr-Abl-CRKL complexes and strongly reduce the proliferation of primary CML blast cells and cell lines established from Bcr-Abl-positive patients. Activation-specific antibodies against phosphorylated MAP kinase (MAPK) showed that MAPK activity is down-regulated in blast cells treated with the CRKLSH3(1) blocker peptides. We conclude that the Bcr-Abl-CRKL complexes are largely dependent on the CRKLSH3(1) domain, that the central mitogenic cascade is down-regulated as a consequence of the disruption of CRKLSH3(1) interactions, and that CRKL therefore contributes to the proliferation of CML blast cells.
Process Control in Practice (2023)

This book covers the most important topics that people working as process control engineers and plant operators will encounter. It focuses on PID control, explains when to use P-, PI-, PD- or PID control as well as PID tuning and includes difficult to control process nonlinearities such as valve stiction or sensor problems. The book also explains advanced control strategies that are necessary when single loop control gives insufficient results. The key features of the text in front of you are: This book is a result of teaching the material to industrial practitioners over three decades and four previous editions in Swedish, each of which was a refi nement of the previous one. A key contribution of this book is the careful selection of what is required when you are at a plant and have to make sense of what you see. The book is written in such a way that it does not assume mathematical knowledge above the compulsory school level. Process control sits between control engineering and process or chemical engineering and often there is a distinct gap between the two. By explaining both the fundamentals of control and the processes the book is written to appeal to control engineers and process engineers alike. The book includes exercises and solutions and thus lends itself for teaching in the classroom.
Towards Robust Semantic Role Labeling (2008)

Most semantic role labeling (SRL) research has been focused on training and evaluating on the same corpus. This strategy, although appropriate for initiating research, can lead to overtraining to the particular corpus. This article describes the operation of assert, a state-of-the art SRL system, and analyzes the robustness of the system when trained on one genre of data and used to label a different genre. As a starting point, results are first presented for training and testing the system on the PropBank corpus, which is annotated Wall Street Journal (WSJ) data. Experiments are then presented to evaluate the portability of the system to another source of data. These experiments are based on comparisons of performance using PropBanked WSJ data and PropBanked Brown Corpus data. The results indicate that whereas syntactic parses and argument identification transfer relatively well to a new corpus, argument classification does not. An analysis of the reasons for this is presented and these generally point to the nature of the more lexical/semantic features dominating the classification task where more general structural features are dominant in the argument identification task.
Fundamental limits of three-dimensional sensing (or: nature makes no presents) (1990)

We will discuss some physical limits of 3D-sensors that work on ''rough'' surfaces. An important result is that the most frequently used principles (laser triangulation and focus sensing with projected light spots) cannot achieve a better depth resolution than given by the Rayleigh depth of field. However we can achieve ''superresolution'' in depth by sacrificing lateral resolution: There is an ''uncertainty relation'' between lateral and longitudinal resolution. 1 .
Photo‐Insensitive Amorphous Oxide Thin‐Film Transistor Integrated with a Plasmonic Filter for Transparent Electronics (2014)

A novel amorphous-indium-gallium-zinc-oxide-based application with stable switching characteristics under negative bias illumination is shown. Metallic nanohole-based plasmonic filters are used for tuning the spectrum of the ambient light source, and the photosensitivity of the a-IGZO-TFT is investigated within a selectively controlled spectral range. The suggested thin-film transistors show greatly improved stability even in a negative bias illumination stress environment.
Hash Chain Links Resynchronization Methods in Video Streaming Security Performance Comparison (2015)

Hash chains provide a secure and light way of security to data authentication including two aspects: Data Integrity and Data Origin Authentication. The real challenge of using the hash chains is how it could recover the synchronization state and continue keeping the hash link in case of packet loss? Based on the packet loss tolerance and some accepted delay of video delivery which are representing the permitted tolerance for heavy loaded applications, we propose different mechanisms for such synchronization recovery. Each mechanism is suitable to use according to the video use case and the low capabilities of end devices. This paper proposes comparative results between them based on the status of each one and its overhead. Then, we propose a hybrid technique based Redundancy Code (RC). This hybrid algorithm is simulated and compared analytically against the other techniques (SHHC, TSP, MLHC and TSS). Moreover, a global performance evaluation in terms of delay and overhead is conducted for all techniques.
High-contrast imaging with an arbitrary aperture: active correction of aperture discontinuities (2013)

We present a new method to achieve high-contrast images using segmented and/or on-axis telescopes. Our approach relies on using two sequential Deformable Mirrors to compensate for the large amplitude excursions in the telescope aperture due to secondary support structures and/or segment gaps. In this configuration the parameter landscape of Deformable Mirror Surfaces that yield high contrast Point Spread Functions is not linear, and non-linear methods are needed to find the true minimum in the optimization topology. We solve the highly non-linear Monge-Ampere equation that is the fundamental equation describing the physics of phase induced amplitude modulation. We determine the optimum configuration for our two sequential Deformable Mirror system and show that high-throughput and high contrast solutions can be achieved using realistic surface deformations that are accessible using existing technologies. We name this process Active Compensation of Aperture Discontinuities (ACAD). We show that for geometries similar to JWST, ACAD can attain at least 10<sup>-7</sup> in contrast and an order of magnitude higher for future Extremely Large Telescopes, even when the pupil features a missing segment" . We show that the converging non-linear mappings resulting from our Deformable Mirror shapes actually damp near-field diffraction artifacts in the vicinity of the discontinuities. Thus ACAD actually lowers the chromatic ringing due to diffraction by segment gaps and strut's while not amplifying the diffraction at the aperture edges beyond the Fresnel regime and illustrate the broadband properties of ACAD in the case of the pupil configuration corresponding to the Astrophysics Focused Telescope Assets. Since details about these telescopes are not yet available to the broader astronomical community, our test case is based on a geometry mimicking the actual one, to the best of our knowledge.
AtKUP1: A Dual-Affinity K<sup>+</sup> Transporter from Arabidopsis (1998)

Plant roots contain both high- and low-affinity transport systems for uptake of K+ from the soil. In this study, we characterize a K+ transporter that functions in both high- and low-affinity uptake. Using yeast complementation analysis, we isolated a cDNA for a functional K+ transporter from Arabidopsis (referred to as AtKUP1 for Arabidopsis thaliana K+ uptake). When expressed in a yeast mutant, AtKUP1 dramatically increased K+ uptake capacity at both a low and high [K+] range. Kinetic analyses showed that AtKUP1-mediated K+ uptake displays a "biphasic" pattern similar to that observed in plant roots. The transition from the high-affinity phase (K(m) of 44 microM) to the low-affinity phase (K(m) of 11 mM) occurred at 100 to 200 microM external K+. Both low- and high-affinity K+ uptake via AtKUP1 were inhibited by 5 mM or higher concentrations of NaCl. In addition, AtKUP1-mediated K+ uptake was inhibited by K+ channel blockers, including tetraethylammonium, Cs+, and Ba2+. Consistent with a possible function in K+ uptake from the soil, the AtKUP1 gene is primarily expressed in roots. We conclude that the AtKUP1 gene product may function as a K+ transporter in Arabidopsis roots over a broad range of [K+] in the soil.
Co-administration of δ- and μ-opioid receptor agonists promotes peripheral opioid receptor function (2010)

Enhancement of peripheral opioid analgesia following tissue injury or inflammation in animal models is well-documented, but clinical results of peripheral opioid therapy remain inconsistent. Previous studies in the central nervous system have shown that co-administration of μ- and δ-opioid receptor agonists can enhance analgesic outcomes; however, less is known about the functional consequences of opioid receptor interactions in the periphery. The present study examines the effects of intraplantar injection of the μ- and δ-opioid receptor agonists, morphine and deltorphin, alone and in combination on behavioral tests of nociception in naïve rats and on potassium-evoked release of CGRP from sciatic nerves of naïve rats. Neither drug alone affected nociceptive behaviors or CGRP release. Two separate measures of mechanical nociceptive sensitivity remained unchanged after co-administration of the two drugs. In contrast, when deltorphin was co-injected with morphine, dose-dependent and peripherally restricted increases in paw withdrawal latencies to radiant heat were observed. Similarly, concentration-dependent inhibition of CGRP release was observed when deltorphin and morphine were administered in sequence prior to potassium stimulation. However, no inhibition was observed when morphine was administered prior to deltorphin. All combined opioid effects were blocked by co-application of antagonists. Deltorphin exposure also enhanced the in vivo and in vitro effects of another μ-opioid receptor agonist, DAMGO. Together, these results suggest that under normal conditions, δ-opioid receptor agonists enhance the effect of μ-opioid receptor agonists in the periphery, and local co-administration of δ- and μ-opioid receptor agonists may improve results of peripheral opioid therapy for the treatment of pain.
Current and future polyalphaolefins (1990)

Abstract Polyalphaolefins currently have a market share of less than 1 per cent in Europe, but this is expected to double in the next 5 years. This paper looks at additive response, rheology, volatility, and oxidation resistance of PAOs; of particular importance are their low temperature capabilities. The results of various tests are given, in comparison with mineral‐based oils. In conclusion, research is under way to investigate the possibilities of ‘tailor‐making’ PAOs by varying production process variables and using a variety of starting olefin streams.
Insulin resistance in clinical and experimental alcoholic liver disease (2015)

Alcoholic liver disease (ALD) is the number one cause of liver failure worldwide; its management costs billions of healthcare dollars annually. Since the advent of the obesity epidemic, insulin resistance (IR) and diabetes have become common clinical findings in patients with ALD; and the development of IR predicts the progression from simple steatosis to cirrhosis in ALD patients. Both clinical and experimental data implicate the impairment of several mediators of insulin signaling in ALD, and experimental data suggest that insulin-sensitizing therapies improve liver histology. This review explores the contribution of impaired insulin signaling in ALD and summarizes the current understanding of the synergistic relationship between alcohol and nutrient excess in promoting hepatic inflammation and disease.
An automatic layout generator for bipolar analog modules (2003)

An automatic layout system dedicated to analog module generation is described. First, a clustering procedure is invoked to partition a given circuit into clusters to be packed into a one-dimensional array. Then, a linear ordering scheme is applied to clusters so that the cluster order can be matched to the signal-flow of the circuit. After an initial placement for circuit elements in each cluster, a block compactor is executed by means of packing blocks in an idle space, and a detailed router is invoked to complete all required interconnections. Finally, a layout compactor is applied to pack the whole layout pattern in a rectangle of the minimum possible area. A number of implementation results are shown to reveal the practicability of the module generator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Opportunities for Innovation in Genetic Transformation of Forest Trees (2018)

The incorporation of DNA into plant genomes followed by regeneration of non-chimeric stable plants (transformation) remains a major challenge for most plant species. Forest trees are particularly difficult as a result of their biochemistry, aging, desire for clonal fidelity, delayed reproduction, and high diversity. We review two complementary approaches to transformation that appear to hold promise for forest trees.
Characterization of a partial cDNA specific for the high molecular weight microtubule-associated protein MAP2 that encodes epitopes shared with paired helical filaments of Alzheimer's disease (1990)

A cDNA encoding epitopes present in paired helical filaments (PHF) in Alzheimer’s disease has been characterized by DNA sequencing and by immunochemical analysis of the encoded recombinant protein fragment. The cDNA encodes 773 amino acids specific of the rat high molecular weight microtubule-associated protein MAP2. This amino acid sequence is localized in the side arm projection domain of MAP2. An antiserum raised against the expressed fusion protein encoded by this cDNA labels the high molecular weight MAP2 but not the 70 kDa MAP2c abundant in developing brain. This antiserum labels PHF in situ but only a proportion of isolated PHF. In situ hybridization on human brain sections did not demonstrate an increase in mRNA for MAP2 in tangle-bearing neurones. We suggest that the association of this MAP2 fragment with PHF in situ results from postradiational modifications of MAP2. © 1990 S. Karger AG, Basel.