gebhart/patrepeval huggingface dataset:
Opacity light fields (2003)

We present new hardware-accelerated techniques for rendering surface light fields with opacity hulls that allow for interactive visualization of objects that have complex reflectance properties and elaborate geometrical details. The opacity hull is a shape enclosing the object with view-dependent opacity parameterized onto that shape. We call the combination of opacity hulls and surface light fields the opacity light field. Opacity light fields are ideally suited for rendering of the visually complex objects and scenes obtained with 3D photography. We show how to implement opacity light fields in the framework of three surface light field rendering methods: view-dependent texture mapping, unstructured lumigraph rendering, and light field mapping. The modified algorithms can be effectively supported on modern graphics hardware. Our results show that all three implementations are able to achieve interactive or real-time frame rates.
Vector based Analog to Digital Converter sequential testing methodology to minimize ATE memory and analysis requirements (2009)

Mixed signal circuits typically require more complex specification based testing as compared to digital circuits, which can be completely tested with structural or simple functional tests. Due to the analog nature of some of the internal nodes and external signals in mixed signal circuits, qualitative functional tests may be required to assure circuit performance at all operating points. Mixed signal blocks such as Analog to Digital Converters (ADC) and Digital to Analog Converters (DAC) act as interfaces between the digital processing modules of the System on a Chip (SoC) and interfacing analog domains. These converters are increasingly common on SoCs due to ever-increasing presence of real world analog signals that use the processing capabilities of the digital blocks. High volume production testing of these mixed-signal components is inefficient due to test complications, resulting in the use of high-performance Automatic Test Equipment (ATE). While various Built-in Self Test (BiST) schemes are proposed to provide the analog test stimulus, the conventional histogram analysis method is still in use for the majority of ADC testing applications. We review a proposal for ADC output test involving a functional pattern, effectively resulting in a real-time-code-analysis. Memory and processing constraints for the ATE are reduced as this vector based method is not ATE memory intensive while providing an output quality measure identical to the conventional histogram method.
CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function (2022)

T cell receptor (TCR)-based therapy has the potential to induce durable clinical responses in patients with cancer by targeting intracellular tumor antigens with high sensitivity and by promoting T cell survival. However, the need for TCRs specific for shared oncogenic antigens and the need for manufacturing protocols able to redirect T cell specificity while preserving T cell fitness remain limiting factors. By longitudinal monitoring of T cell functionality and dynamics in 15 healthy donors, we isolated 19 TCRs specific for Wilms' tumor antigen 1 (WT1), which is overexpressed by several tumor types. TCRs recognized several peptides restricted by common human leukocyte antigen (HLA) alleles and displayed a wide range of functional avidities. We selected five high-avidity HLA-A*02:01-restricted TCRs, three that were specific to the less explored immunodominant WT1<sub>37-45</sub> and two that were specific to the noncanonical WT1<sub>-78-64</sub> epitopes, both naturally processed by primary acute myeloid leukemia (AML) blasts. With CRISPR-Cas9 genome editing tools, we combined TCR-targeted integration into the TCR α constant (<i>TRAC</i>) locus with TCR β constant (<i>TRBC</i>) knockout, thus avoiding TCRαβ mispairing and maximizing TCR expression and function. The engineered lymphocytes were enriched in memory stem T cells. A unique WT1<sub>37-45</sub>-specific TCR showed antigen-specific responses and efficiently killed AML blasts, acute lymphoblastic leukemia blasts, and glioblastoma cells in vitro and in vivo in the absence of off-tumor toxicity. T cells engineered to express this receptor are being advanced into clinical development for AML immunotherapy and represent a candidate therapy for other WT1-expressing tumors.
Very small IF resonator filters using reflection of shear horizontal wave at free edges of substrate (2002)

A shear horizontal (SH) wave has the characteristic of complete reflection at the free edges of a substrate with a large dielectric constant. A conventional surface acoustic wave (SAW) resonator filter requires reflectors consisting of numerous grating fingers on both sides of interdigital transducers (IDTs). On the contrary, it is considered that small-sized and low loss resonator filters without reflectors consisting of grating fingers can be realized by exploiting this characteristic of the SH wave or the Bleustein-Gulyaev-Shimizu (BGS) wave. There are two types of resonator filters: transversely coupled and longitudinally coupled. No transversely coupled filters (neither conventional nor edge-reflection) using the SH wave on a single-crystal substrate have been realized until now, because two transverse modes (symmetrical and asymmetrical modes) are not easily coupled. However, the authors have realized small low loss transversely coupled resonator filters in the range of 25 to 52 MHz using edge reflections of the BGS wave on piezoelectric ceramic (PZT: Pb(Zr,Ti)O3) substrates for the first time by developing methods by which the two transverse modes could be coupled. On the other hand, longitudinally coupled resonator filters using edge reflection of the SH or BGS wave always have large spurious responses because of the even modes in the out-of-band range, because the frequencies of even modes do not coincide with the nulls of the frequency spectra of the IDTs. Consequently, longitudinally coupled resonator filters using the edge reflection of the SH wave have not been realized. By developing a method of reducing the spurious responses without increasing of the insertion loss, the authors have realized small low loss longitudinally coupled resonator filters in the range of 40 to 190 MHz using edge reflection of BGS or SH waves on PZT or 36 degrees-rotated-Y X-propagation LiTaO3 substrates for the first time. Despite being intermediate frequency (IF) filters, their package (3 x 3 x 1.03 mm3) sizes are as small as those of radio frequency (RF) SAW filters.
A VLSI Approach to Sound Synthesis (1985)

We present a VLSI approach to the generation of musical\nsounds. This approach allows the generation of very\nrich musical sounds using models that are easy to control\nand have parameters corresponding to physical attributes\nof musical instruments.\n\nPast efforts in musical sound generation have been plagued\nwith several problems. The computational bandwidth that\nis needed to compute musical sounds is enormous, and it is\nhopeless to compute sounds in real time on a conventional\ngeneral purpose computer. An even larger problem with\nprevious efforts is the massive bandwidth needed for control\nand update of parameters.\n\nSounds that come from physical sources are naturally represented by differential equations in time. Since there is a straight-forward correspondence between differential equations and finite difference equations, we can model musical instruments as simultaneous finite difference equations. Musical sounds can be produced by solving, in real time, the difference equations that model instruments.\n\nA natural architecture for solving finite difference equations is one with an interconnection matrix between processors that can be reconfigured or "programmed". A realization of a new instrument involves reconfiguring the connection matrix between the processing elements along with configuring connections to the outside world both for control and updates of parameters.\n\nFor our basic unit of computation we have chosen a unit we\ncall a UPE (Universal Processing Element) - it computes\nthe function:\n\nA + BM + (1 - M)D\n\nWe have implemented in nMOS technology a prototype systems\nof UPEs and have been successful in implementing\nsome simple musical instruments on the system of UPEs.
Miniature fiber-optic force sensor based on low-coherence Fabry-Pérot interferometry for vitreoretinal microsurgery (2012)

During vitreoretinal surgery, the surgeon manipulates retinal tissue with tool-to-tissue interaction forces below the human sensory threshold. A force sensor (FS) integrated with conventional surgical tools may significantly improve the surgery outcome by providing tactile feedback to the surgeon. We designed and built a surgical tool integrated with a miniature FS with an outer diameter smaller than 1 mm for vitreoretinal surgery based on low-coherence Fabry-Pérot (FP) interferometry. The force sensing elements are located at the tool tip which is in direct contact with tissue during surgery and the FP cavity length is interrogated by a fiber-optic common-path phase-sensitive optical coherence tomography (OCT) system. We have calibrated the FS's response to axial and lateral forces and conducted experiments to verify that our FS can simultaneously measure both axial and lateral force components.
Scatter Correction Method by Temporal Primary Modulation in X-Ray CT (2012)

Scattered radiation is a major cause of image degradation in modern cone-beam computed tomography (CBCT) scanners, both in the medical field as well as in non-destructive testing. In this work, we present a novel method for scatter correction in CBCT based on temporal primary modulation. In contrast to primary modulation methods in the spatial domain reported in the literature, temporal modulation does not suffer inaccuracies in the scatter image caused by overlapping spectral copies. Additionally, it is shown that the maximum detectable frequency in the scatter function can be increased by a factor of two compared to spatial primary modulation methods. Moreover, the measuring time is not increased. We demonstrate first experimental results obtained with an industrial CBCT scanner employing our new scatter correction method.
First-person hyper-lapse videos (2014)

We present a method for converting first-person videos, for example, captured with a helmet camera during activities such as rock climbing or bicycling, into hyper-lapse videos, i.e., time-lapse videos with a smoothly moving camera. At high speed-up rates, simple frame sub-sampling coupled with existing video stabilization methods does not work, because the erratic camera shake present in first-person videos is amplified by the speed-up. Our algorithm first reconstructs the 3D input camera path as well as dense, per-frame proxy geometries. We then optimize a novel camera path for the output video that passes near the input cameras while ensuring that the virtual camera looks in directions that can be rendered well from the input. Finally, we generate the novel smoothed, time-lapse video by rendering, stitching, and blending appropriately selected source frames for each output frame. We present a number of results for challenging videos that cannot be processed using traditional techniques.
Hepcidin and Ferroportin: The New Players in Iron Metabolism (2011)

Systemic iron homeostasis is regulated by the interaction of the peptide hormone, hepcidin and the iron exporter, ferroportin. Mutations in FPN1, the gene that encodes ferroportin, result in iron-overload disease that shows dominant inheritance and variation in phenotype. The inheritance of ferroportin-linked disorders can be explained by the finding that ferroportin is a multimer and the product of the mutant allele participates in multimer formation. The nature of the ferroportin mutant can explain the variation in phenotype, which is due to either decreased iron export activity or decreased ability to be downregulated by hepcidin. Iron export through ferroportin is determined by the concentration of ferroportin in plasma membrane, which is the result of both synthetic and degradation events. Ferroportin degradation can occur by hepcidin-dependent and hepcidin-independent internalization. Ferroportin expression is regulated transcriptionally and posttranslationally.
Molecular Cloning of a cDNA Encoding the "61-kDa" Calmodulin- stimulated Cyclic Nucleotide Phosphodiesterase (1993)

We have isolated a 2287-bp cDNA encoding the 61kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase (CaM PDE) from a bovine brain library. A large open reading frame within the cDNA encodes a 530-residue polypeptide which is identical to the sequence of the purified protein previously determined by direct amino acid sequencing. Moreover, COS cells transfected with the cDNA express a CAMP and cGMP hydrolytic activity that is stimulated by calcium and calmodulin, confirming that the cDNA represents a mRNA species encoding a CaM PDE isozyme. RNase protection analyses indicate that either 61kDa CaM PDE mRNA or structurally related transcripts encoding different CaM PDE isoforms are expressed in a tissue-specific manner. Total RNA isolated from brain (cerebral cortex, basal ganglia, hippocampus, cerebellum, and medulla/spinal cord), heart, aorta, liver, kidney outer medulla, kidney papilla, trachea, and lung completely protected a 410-base antisense riboprobe corresponding to sequence encoding a portion of the catalytic domain. Little or no protection was detected using adrenal cortex, adrenal medulla, liver, kidney cortex, spleen, or T-lymphocyte total RNA. Only brain RNA completely protected a 240-base antisense riboprobe corresponding to the 61-kDa CaM PDE amino terminus encompassing a putative calmoddin-binding domain. However, heart, aorta, liver, kidney, trachea, and lung RNA protected 150 bases of this riboprobe suggesting that these tissues express an isoform structurally related to the 61-kDa CaM PDE. Northern analysis of mRNA isolated from brain, heart, aorta, liver, kidney, lung, and trachea revealed that the cDNA hybridizes with a 3.8- and a 4.4-kb (kilobase) mRNA species. Interestingly, Northern blots of bovine cerebral cortex and heart mRNA probed under stringent conditions with antisense transcripts corresponding to either the 5‘- or 3”untranslated sequence of the 61-kDa CaM PDE cDNA hybridized with only the 4.4-kb mRNA from both tissues. Since different, yet structurally similar CaM PDE isoforms are expressed in brain and in heart, this result, in addition to the RNase protection data, is consistent with the idea that the mRNAs encoding these two CaM PDE isoforms are products of an alternately spliced gene. * This research was supported by National Institutes of’ Health Grant DK21023. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “aduertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. The nucleotide sequencels) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession numberfs)
A Sucrose‐Mediated Sol–Gel Technique for the Synthesis of <scp> <scp>MgO</scp> </scp> – <scp> <scp>Y</scp> </scp> <sub>2</sub> <scp> <scp>O</scp> </scp> <sub>3</sub> Nanocomposites (2012)

A sucrose‐mediated aqueous sol–gel procedure was developed to synthesize MgO – Y 2 O 3 nanocomposite ceramics for potential optical applications. The synthesis involves the generation of a precursor foam containing Mg 2+ and Y 3+ cations via the chemical and thermal degradation of sucrose molecules in aqueous solution. Subsequent calcination and crushing of the foam gave MgO – Y 2 O 3 nanocomposites in the form of thin mesoporous flake‐like powder particles with uniform composition and surface areas of 27–85 m 2 g − 1 , depending on calcination conditions. The flakes exhibited a homogeneous microstructure comprising intimately mixed nanoscale grains of the cubic MgO and Y 2 O 3 phases. This microstructure was resistant to grain coarsening with average grain sizes of less than 100 nm for calcination temperatures of up to 1200°C. The results indicate that the sucrose‐mediated sol–gel process is a simple effective method for making nanoscale mixed oxides.
Outlier Detection with Uncertain Data (2008)

In recent years, many new techniques have been developed for mining and managing uncertain data. This is because of the new ways of collecting data which has resulted in enormous amounts of inconsistent or missing data. Such data is often remodeled in the form of uncertain data. In this paper, we will examine the problem of outlier detection with uncertain data sets. The outlier detection problem is particularly challenging for the uncertain case, because the outlier-like behavior of a data point may be a result of the uncertainty added to the data point. Furthermore, the uncertainty added to the other data points may skew the overall data distribution in such a way that true outliers may be masked. Therefore, it is critical to be able to remove the effects of the uncertainty added both at the aggregate level as well as at the level of individual data points. In this paper, we will examine a density based approach to outlier detection, and show how to use it to remove the uncertainty from the underlying data. We present experimental results illustrating the effectiveness of the method.
Surface-enhanced Raman spectroscopy with monolithic nanoporous gold disk substrates (2013)

Monolithic hierarchical nanoporous gold disks, 500 nm in diameter, 75 nm in thickness and 3.5 nm in pore radius, have been fabricated by hybrid processes. A surface-enhanced Raman scattering enhancement factor of at least 10(8) has been obtained on individual disks using benzenethiol self-assembled monolayer with 785 nm laser excitation.
Semi‐automatic tuning of PID gains for atomic force microscopes (2009)

Abstract The control of a typical commercial Atomic Force Microscope (AFM) is through some variant on a Proportional, Integral, Derivative (PID) controller. Typically, the gains are hand tuned so as to keep the bandwidth of the system far below the first resonant frequency of the actuator. This paper shows a straightforward method of selecting PID gains from the actuator model so as to allow considerably higher bandwidths. Copyright © 2009 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Reality Skins: Creating Immersive and Tactile Virtual Environments (2016)

Reality Skins enables mobile and large-scale virtual reality experiences, dynamically generated based on the user's environment. A head-mounted display (HMD) coupled with a depth camera is used to scan the user's surroundings: reconstruct geometry, infer floor plans, and detect objects and obstacles. From these elements we generate a Reality Skin, a 3D environment which replaces office or apartment walls with the corridors of a spaceship or underground tunnels, replacing chairs and desks, sofas and beds with crates and computer consoles, fungi and crumbling ancient statues. The placement of walls, furniture and objects in the Reality Skin attempts to approximate reality, such that the user can move around, and touch virtual objects with tactile feedback from real objects. Each possible reality skins world consists of objects, materials and custom scripts. Taking cues from the user's surroundings, we create a unique environment combining these building blocks, attempting to preserve the geometry and semantics of the real world.We tackle 3D environment generation as a constraint satisfaction problem, and break it into two parts: First, we use a Markov Chain Monte-Carlo optimization, over a simple 2D polygonal model, to infer the layout of the environment (the structure of the virtual world). Then, we populate the world with various objects and characters, attempting to satisfy geometric (virtual objects should align with objects in the environment), semantic (a virtual chair aligns with a real one), physical (avoid collisions, maintain stability) and other constraints. We find a discrete set of transformations for each object satisfying unary constraints, incorporate pairwise and higher-order constraints, and optimize globally using a very recent technique based on semidefinite relaxation.
Dual-catalytic decarbonylation of fatty acid methyl esters to form olefins (2018)

The homogeneous dehydrative decarbonylation of fatty acid methyl esters (FAMEs) to form olefins is reported. In order to facilitate cleavage of the unactivated acyl C-O bond of the alkyl ester, a one pot dual-catalytic directing group strategy was developed through optimization of the individual transesterification and decarbonylation reaction steps.
Current sensorless control of a boost-type switch mode rectifier using an adaptive inductor model (2015)

Boost-type switch-mode rectifiers (SMR) commonly use a resistor or a magnetic current sensor to measure the instantaneous input or inductor current that is used as the feedback to the current controller. In this paper a novel current sensorless scheme is described that computes the inductor current from the measured inductor voltage in a single-phase boost-type SMR using an adaptive low pass filter. This calculation requires an estimate of the inductance and the equivalent series resistance of the inductor coil. Both these parameters are dependent on operating conditions and hence have to be updated continuously. This is done using an adaptive model of the inductor that computes these parameters of the inductor once in every half cycle of the input current. The adaptation scheme is robust against parameter variations. Simulation and experimental results confirm the effectiveness of the proposed technique which provides comparable performance to standard measured feedback current scheme both under steady-state and transient conditions.
P43/pro-EMAPII: A Potential Biomarker for Discriminating Traumatic Versus Ischemic Brain Injury (2009)

To gain additional insights into the pathogenic cellular and molecular mechanisms underlying different types of brain injury (e.g., trauma versus ischemia), recently attention has focused on the discovery and study of protein biomarkers. In previous studies, using a high-throughput immunoblotting (HTPI) technique, we reported changes in 29 out of 998 proteins following acute injuries to the rat brain (penetrating traumatic versus focal ischemic). Importantly, we discovered that one protein, endothelial monocyte-activating polypeptide II precursor (p43/pro-EMAPII), was differentially expressed between these two types of brain injury. Among other functions, p43/pro-EMAPII is a known pro-inflammatory cytokine involved in the progression of apoptotic cell death. Our current objective was to verify the changes in p43/pro-EMAPII expression, and to evaluate the potentially important implications that the differential regulation of this protein has on injury development. At multiple time points following either a penetrating ballistic-like brain injury (PBBI), or a transient middle cerebral artery occlusion (MCAo) brain injury, tissue samples (6-72 h), CSF samples (24 h), and blood samples (24 h) were collected from rats for analysis. Changes in protein expression were assessed by Western blot analysis and immunohistochemistry. Our results indicated that p43/pro-EMAPII was significantly increased in brain tissues, CSF, and plasma following PBBI, but decreased after MCAo injury compared to their respective sham control samples. This differential expression of p43/pro-EMAPII may be a useful injury-specific biomarker associated with the underlying pathologies of traumatic versus ischemic brain injury, and provide valuable information for directing injury-specific therapeutics.