gebhart/patrepeval huggingface dataset:
Fluorinated Conformationally Restricted γ-Aminobutyric Acid Aminotransferase Inhibitors (2006)

On the basis of the structures of several potent inhibitor molecules for gamma-aminobutryric acid aminotransferase (GABA-AT) that were previously reported, six modified fluorine-containing conformationally restricted analogues were designed, synthesized, and tested as GABA-AT inhibitors. The syntheses of all six molecules followed from a readily synthesized ketone intermediate. Three of the molecules were found to be irreversible inhibitors of GABA-AT with comparable or larger k(inact)/K(I) values than that of vigabatrin, a clinically used antiepilepsy drug, and the other three were reversible inhibitors. A possible mechanism for inactivation by one of the inactivators is proposed.
On scheduling using parallel input-output queued crossbar switches with no speedup (2002)

We propose an efficient parallel switching architecture (PSA) that requires no speedup and guarantees bounded delay. Our architecture consists of /spl kappa/ crossbar switches operating in parallel under the control of a single scheduler, with /spl kappa/ being independent of N the number of inputs and outputs of the PSA. Arriving traffic is demultiplexed (spread) over the /spl kappa/ identical crossbar switches, switched to the correct output, and multiplexed (combined) before departing from the parallel switch. We show that by using an appropriate demultiplexing strategy at the inputs and by applying the same matching at each of the /spl kappa/ parallel crossbar switches during each slot, our scheme guarantees that the cells of a flow can be read in FIFO order from the output queues of the crossbar switches, thus eliminating the need for cell resequencing. Further, by allowing the PSA scheduler to examine the state of only the first of the /spl kappa/ parallel switches, our scheme also reduces considerably the amount of state information required at the scheduler. The scheduling algorithms that we develop are based on existing practical scheduling algorithms for crossbar switches, and have an additional communication complexity that is optimal up to a constant factor. Our approach also provides a way to build a high capacity switch/router that can support line rates that are higher than the speed at which the parallel switches themselves operate.
Novel potassium-based catalyst generated from alkylmagnesium compounds for the preparation of highly crystalline trans-1,4-polybutadiene (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel potassium-based catalyst generated from alkylmagnesium compounds for the preparation of highly crystalline trans-1,4-polybutadieneDennis B. Patterson and Adel F. HalasaCite this: Macromolecules 1991, 24, 7, 1583–1589Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ma00007a021https://doi.org/10.1021/ma00007a021research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wire-inhomogeneity detector (1982)

Bti might have a moderate impact on adult vector populations mediated via transient reductions in larval populations. However, this effect is not sustained probably due to rapid re-infestation. Bti spray, if implemented, can only play a supplementary role to other vector control methods.
Application of DFT in Iron Sulfide Scale Removal from Oil and Gas Wells (2019)

Summary Scale formation including those formed by iron sulfides have been a major hassle in the upstream sector of the oil and gas industry for many decades. Iron Sulfide scales including pyrite (FeS2) and troilite (FeS) often form a precipitate in the matrix formation, tubulars and other downhole equipment in the wells resulting in plant shutdown. Herein, a molecular modelling tool known as Density Functional Theory (DFT) is used to study the binding affinity of chelating agents to ferrous ion, which is the state of iron in pyrite scale. The calculated binding affinity of the chelating agents to Fe2+ increased in the order; GLDA < HEDTA < EDTA < DTPA which correlated with what has been reported experimentally. The number of nitrogen atoms in a chelating agent plays a predominant role in its binding ability. This could give insights on how novel chemicals could be designed which would be more effective and environmentally friendly in iron sulfide scale removal.
Magnetic stimulation of subthalamic nucleus neurons using micro-coils for deep brain stimulation (2013)

Recently micro-magnetic stimulation (μMS) with sub-millimeter coils has been successfully used to stimulate retinal neurons in vitro. This raises the possibility that such coils could be used in a wide range of neural prosthetics, as they may provide a safer alternative to direct electrical stimulation. However, the ability of μMS to modulate the neuronal activity of brain neurons has not been studied. Here we show that μMS strongly modulates the neural activity of subthalamic nucleus (STN) neurons in vitro. Cell attached patch clamp was used to record neural activity in response to both pulsatile and sinusoidal waveforms. Pulsatile stimulation was not very effective but continuous presentation of low-frequency (500Hz) sinusoidal bursts of μMS silenced STN neurons. This work supports further investigation of μMS as an alternative to existing electrically-based DBS systems.
Nonlinear harmonic generation and devices in doubly resonant Kerr cavities (2009)

We describe a theoretical analysis of the nonlinear dynamics of third-harmonic generation $(\ensuremath{\omega}\ensuremath{\rightarrow}3\ensuremath{\omega})$ via Kerr $({\ensuremath{\chi}}^{(3)})$ nonlinearities in a resonant cavity with resonances at both $\ensuremath{\omega}$ and $3\ensuremath{\omega}$. Such a doubly resonant cavity greatly reduces the required power for efficient harmonic generation, by a factor of $\ensuremath{\sim}V∕{Q}^{2}$, where $V$ is the modal volume and $Q$ is the lifetime, and can even exhibit 100% harmonic conversion efficiency at a critical input power. However, we show that it also exhibits a rich variety of nonlinear dynamics, such as multistable solutions and long-period limit cycles. We describe how to compensate for self- and cross-phase modulation (which otherwise shifts the cavity frequencies out of resonance), and how to excite the different stable solutions (and especially the high-efficiency solutions) by specially modulated input pulses.
Combined M-ary Code Shift/Differential Chaos Shift Keying for Low-Rate UWB Communications (2006)

M-ary code shift keying (MCSK) is combined with differential chaos shift keying (DCSK) for low-rate UWB communications. The combined M-ary code shift (MCS)/DCSK shifts the reference-information signal pair to the location determined by (log/sub 2/ M)-bit data, hence transmitting a (1 + log/sub 2/ M)-bit symbol for the duration of one bit transmitted using DCSK, which in turn can be used to increase the silent periods within and between transmitted signal pairs. The resulting signaling format improves the bit error probability (BEP) performance of DCSK-based systems without altering the receiver structure or increasing the computational complexity, and provides longer silent periods to combat the worse effects of multipath (MP) fading. These results can be used to improve the ranging and location capability of DCSK-based low-rate ultra wideband (UWB) communication systems.
High Breakdown Voltage and Low Specific On-resistance C-doped GaN-on-sapphire HFETs for Low-loss and High-power Switching Applications (2007)

High-quality C-doped GaN buffers grown on sapphire substrates were employed for the fabrication of high-power AlGaN/GaN heterojunction field effect transistors (HFETs). The fabricated device exhibited a very high breakdown voltage (BV) over 1350 V and low specific on-resistance (ARDS(ON)) of 3.4 mΩm2. This result is very close to the 4H-SiC theoretical limit and a record achievement for GaN-based HFETs realized on sapphire substrates, to the best of our knowledge.
ChemInform Abstract: Lignocellulosic Biomass Pretreatment Using AFEX (2011)

Abstract Review: 11 refs.
Improved Garbled Circuit Building Blocks and Applications to Auctions and Computing Minima. (2009)

Abstract. We consider generic Garbled Circuit (GC)-based techniques for Secure Function Evaluation (SFE) in the semi-honest model. We describe efficient GC constructions for addition, subtraction, multiplication, and comparison functions. Our circuits for subtraction and comparison are approximately two times smaller (in terms of garbled tables) than previous constructions. This implies corresponding computation and communication improvements in SFE of functions using our efficient building blocks. The techniques rely on recently proposed “free XOR ” GC technique. Further, we present concrete and detailed improved GC protocols for the problem of secure integer comparison, and related problems of auctions, minimum selection, and minimal distance. Performance improvement comes both from building on our efficient basic blocks and several problemspecific GC optimizations. We provide precise cost evaluation of our constructions, which serves as a baseline for future protocols.
Infrared imaging of defects in materials with chaotic Sonic excitation (2010)

Infrared imaging of defects in materials has become a standard tool in nondestructive evaluation (NDE). The most recent version of this technology uses ultrasound to excite the defects by friction or other dissipative effects. This version is greatly enhanced by the use of "chaotic" sound.
Phosphorylation of magainin‐2 by protein kinase C and inhibition of protein kinase C isozymes by a synthetic analogue of magainin‐2‐amide (1990)

Magainins are a family of antimicrobial peptides present in the skin extracts of Xenopus laevis. Both magainin-1 and -2 do not have any significant effect on the activity of protein kinase C (PKC). Magainin-2 was found to be readily phosphorylated by PKC to 0.5 mol 32P/mol of peptide. Neither magainin-1, which has a sequence of S8AGK and not S8AKK as in the case of magainin-2, nor the magainin-2 analogue with substitution of Ala for Ser8 was phosphorylated by the kinase, suggesting that Ser8 is the phosphorylation site of magainin-2. One synthetic analogue of magainin, designated magainin B, which has a greater tendency for alpha-helix formation in non-aqueous environment than the parent peptide resulting from substitution of Ser8, Gly13, and Gly18 with Ala in magainin-2-amide, is a potent inhibitor of PKC. This peptide inhibits all three PKC isozymes with IC50 less than 20 microM. Magainin B also inhibits the binding of [3H]phorbol 12,13-dibutyrate to the kinase. These results suggest that magainin-2 may be modified by PKC through phosphorylation and that certain synthetic analogues of magainins may be used as inhibitors of PKC.
Novel Multivariate Analysis for Soil Carbon Measurements Using Laser‐Induced Breakdown Spectroscopy (2010)

Laser‐induced breakdown spectroscopy (LIBS), a rapid and potentially field‐deployable technology for estimating total C in soil, represents a novel approach to address important issues in soil science and C management. Our study has shown that models relating LIBS signal intensity at 247.85 nm to total C concentration determined by dry combustion vary as a function of elemental and textural characteristics of the soil, and, to a lesser extent, wavelength and excitation energy of the laser. To better quantify these sources of variation, two wavelengths and three excitation energies were used to analyze soils from various locations. The emission line of C at 247.85 nm was pronounced at an excitation wavelength of 532 nm and energy of 45 mJ, but it was largely obscured by the 248.9‐nm Fe line at 1064 nm and excitation energies of 90 and 135 mJ. Univariate analysis revealed linear but soil‐specific correlations between the signal intensity at 247.85 nm and total C concentration. A single and robust calibration model correlating LIBS spectra, collected at a laser wavelength of 532 nm and an excitation energy of 45 mJ, to C concentration in all samples was obtained using a multivariate approach. Several emission lines in addition to the strong C line contributed significantly to the multivariate model. These results show that multivariate analysis can be used to construct a robust calibration model for LIBS spectra and therein provide a reliable estimate of total soil C. Such results must be confirmed for a broader range of soils, yet crop and soil scientists, C managers, and instrument developers should find these results encouraging.
A new aminoglycoside antibiotic G-367 S1, 2'-N-formylsisomicin fermentation, isolation and characterization. (1983)

A new aminoglycoside antibiotic, G-367 S1 (2'-N-formylsisomicin, C20H37N5O8) produced by a rare actinomycetes, Dactylosporangium thailandense G-367 (FERM-P 4840) has been isolated by column chromatography on a cation-exchange resin. G-367 S1 is active against Gram-positive and Gram-negative bacteria.
Joint image reconstruction and motion parameter estimation for free-breathing navigator-gated cardiac MRI (2013)

We propose an acquisition and reconstruction technique for accelerated free-breathing cardiac MRI acquisitions. For the acquisition, a random undersampling pattern, including a fully-sampled center of k-space, is generated prospectively. The k-space lines specified by this undersampling pattern is acquired with respiratory navigating (NAV), where only the central k-space lines are acquired within the prespecified gating window. For the outer k-space lines, if the NAV signal corresponding to a k-space segment is outside the gating window, the segment is rejected, but not re-acquired. The reconstruction approach jointly estimates the underlying image using a compressed-sensing based approach, and the translational motion parameters for each segment for the outer k-space segments acquired outside the gating window. The feasibility of the approach is demonstrated in healthy adult subjects using whole-heart coronary MRI with a 3-fold accelerated random undersampling pattern. The proposed acquisition and reconstruction technique is compared to parallel imaging with uniform undersampling with 3-fold undersampling. The two techniques exhibit similar image quality with a shorter acquisition time for the proposed approach (4:25±0:31 minutes versus 6:52±0:19).
Pigeon: a wireless two-way messaging system (1997)

Wireless messaging is an integral component of universal personal communication services (PCSs). Its growth is likely to be further fueled by the availability of new data capabilities in the new PCS air interfaces. Our research focuses on high-level issues such as new messaging functionalities, high-layer protocols, and overall system design. Pigeon is our proposal of a wireless two-way messaging system. The novelty of our system lies in: (1) the techniques used in mitigating the wireless media and end device constraints, (2) the functionalities provided, and (3) its modular architecture. Examples of (1) include the use of asymmetric protocols and the introduction of user agents. Examples of (2) include group addressing, transaction support, and flexible messages. The modularity of Pigeon allows its individual components to be adopted by specific systems, A prototype of Pigeon has been implemented, and is operational at Bell Laboratories. We describe the motivation, design, and functionality of Pigeon. We also present, as an example, a mapping of Pigeon to a standard cellular/PCS messaging system.
RNA-Mediated Trans-Activation of Transcription from a Viral RNA (1998)

The red clover necrotic mosaic virus genome is composed of two single-stranded RNA components, RNA-1 and RNA-2. The viral capsid protein is translated from a subgenomic RNA (sgRNA) that is transcribed from genomic RNA-1. Here, a 34-nucleotide sequence in RNA-2 is shown to be required for transcription of sgRNA. Mutations that prevent base-pairing between the RNA-1 subgenomic promoter and the 34-nucleotide trans-activator prevent expression of a reporter gene. A model is proposed in which direct binding of RNA-2 to RNA-1 trans-activates sgRNA synthesis. This RNA-mediated regulation of transcription is unusual among RNA viruses, which typically rely on protein regulators.
Worldwide Abundance and Distribution of <i>Bacillus thuringiensis</i> Isolates (1989)

We found the insect control agent Bacillus thuringiensis to be a ubiquitous soil microorganism. Using acetate selection to screen soil samples, we isolated B. thuringiensis in 785 of 1,115 soil samples. These samples were obtained in the United States and 29 other countries. A total of 48% of the B. thuringiensis isolates (8,916 isolates) fit the biochemical description of known varieties, while 52% represented undescribed B. thuringiensis types. Over 60% (1,052 isolates) of the isolates tested for toxicity were toxic to insects in the orders Lepidoptera or Diptera. Soil samples were collected from various habitats, including those habitats with different numbers of insects. The current presence of insects did not predict the presence of B. thuringiensis in a particular soil sample. B. thuringiensis was most abundant in samples from Asia.
Stable color-center laser in OH-doped NaCl operating in the 141- to 181-μm region (1986)

A powerful and stable color-center laser based on a perturbed F(2)(+) center has been demonstrated in additively colored NaCl:OH(-) crystals. The OH(-) impurity has been positively identified as the key dopant for creating the color-center laser in NaCl. The laser tunes smoothly over the 1.41- to 1.81-microm region with a maximum cw power of 1.25 W when pumped by a 9-W cw Nd:YAG laser operating at 1.06 microm. Laser operation for periods of several weeks has been monitored with no observable fading in output power. In addition, mode-locked pulses of 5-psec duration have been generated in a synchronously pumped arrangement, tunable from 1.47 to 1.73 microm with an average power of 450 mW at the peak of the tuning curve.
Large Mode Area Fiber Design With Asymmetric Bend Compensation (2011)

Get PDF Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text J. M. Fini, "Large Mode Area Fiber Design With Asymmetric Bend Compensation," in CLEO:2011 - Laser Applications to Photonic Applications, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper JWA30. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Class Based and Shared Resources Access Control for Distributed Video-on-Demand System (2013)

We are proposing an efficient admission control policy for Video-on-Demand (VOD) system. Traditional Admission control system uses either threshold or resource capacity to accept or reject any incoming request. The distinction of the proposed scheme from the previous work includes: (1) a new concept of integrating the both schemes (shared resource admission control and class base admission control) into one system, is introduced (2) another new concept of Probability, is introduced to access the shared resource (Ports, Bandwidth). In the proposed system, total capacity of VOD server (ports) is partitioned equal to the number of classes plus shared area. When a request arrives at VOD server, it will be admitted if there is capacity to its corresponding partition, otherwise we will check the capacity of shared area and admit it with some probability. If there is no capacity in shared area or no probability, the request will be rejected. The evaluation of the proposed system is done by the simulation model. Numbers of blocked requests are calculated for performance measure. It is observed from the simulation results that proposed admission control policy not only improves the performance of high-priority classes but also reduces a lot the total number of rejected requests.
An Overview of Gibberellin Metabolism Enzyme Genes and Their Related Mutants in Rice  (2004)

To enhance our understanding of GA metabolism in rice (Oryza sativa), we intensively screened and identified 29 candidate genes encoding the following GA metabolic enzymes using all available rice DNA databases: ent-copalyl diphosphate synthase (CPS), ent-kaurene synthase (KS), ent-kaurene oxidase (KO), ent-kaurenoic acid oxidase (KAO), GA 20-oxidase (GA20ox), GA 3-oxidase (GA3ox), and GA 2-oxidase (GA2ox). In contrast to the Arabidopsis genome, multiple CPS-like, KS-like, and KO-like genes were identified in the rice genome, most of which are contiguously arranged. We also identified 18 GA-deficient rice mutants at six different loci from rice mutant collections. Based on the mutant and expression analyses, we demonstrated that the enzymes catalyzing the early steps in the GA biosynthetic pathway (i.e. CPS, KS, KO, and KAO) are mainly encoded by single genes, while those for later steps (i.e. GA20ox, GA3ox, and GA2ox) are encoded by gene families. The remaining CPS-like, KS-like, and KO-like genes were likely to be involved in the biosynthesis of diterpene phytoalexins rather than GAs because the expression of two CPS-like and three KS-like genes (OsCPS2, OsCPS4, OsKS4, OsKS7, and OsKS8) were increased by UV irradiation, and four of these genes (OsCPS2, OsCPS4, OsKS4, and OsKS7) were also induced by an elicitor treatment.
Enhancing Plant Seed Oils for Human Nutrition (2008)

The age of true designer plant oils has arrived. Using the tools of biotechnology, it is now possible to modify the fatty acid content of oilseed plants to change the relative abundance of individual fatty acids in seed oil for health purposes or to produce nutritional fatty acids not normally found