gebhart/patrepeval huggingface dataset:
A macro-bend fiber based wavelength demodulation system for optical fiber sensing applications (2008)

This thesis considers the design and development of a wide range allfiber interrogation system with a rapid measurement capability for extracting reliable measurand information from fiber Bragg grating sensors. Existing passive and active interrogation systems have certain limitations and do not satisfy all requirements. In this thesis a wavelength demodulation system is proposed, based on a macro-bend fiber filter employed in a ratiometric detection scheme. A theoretical model and analysis of an edge filter based ratiometric wavelength measurement (RWM) system is presented. A fiber edge filter is realized by carefully selecting an appropriate bend radius and number of bend turns of a standard single-mode fiber with an applied absorption layer. The calibration and characterization of the system are carried out experimentally and the effect of the signal-to-noise ratio (SNR) of the source is studied. It is shown that the SNR limits the measurable wavelength range of the system. A complete noise model for an edge filter based ratiometric system is developed and the noise analysis shows that increasing the slope of the edge filter is not necessarily a guaranteed approach to increasing the resolution of the system. The effect of polarization on the system is also investigated. The origins of the polarization dependency of the components, the macro-bend fiber filter and the 3 dB coupler, are identified and the effect of polarization dependent loss (PDL) on the RWM system with concatenated PDL components is investigated. To eliminate the polarization dependency, a novel twisted macro-bend fiber edge filter based system is proposed and demonstrated. As the bend loss in single-mode fiber is a function of temperature, an investigation to estimate the temperature induced instabilities in the system is carried out. The macro-bend fiber based interrogation system is used to extract information from an array of FBGs with different peak wavelengths using a best fit slope. A performance evaluation of the interrogation system is carried out and static strain, dynamic strain and temperature are measured. The investigation of the temperature dependence of the bend loss edge filter also led to the development of a new all-fiber temperature sensor, which is described, demonstrating a linear relation between the bend loss of a single-mode fiber and temperature in a sensing application for the first time.
Benzimidazole Derivatives: Synthesis, Physical Properties, and n‐Type Semiconducting Properties (2014)

A series of new benzimidazole derivatives were synthesized by the solid-state condensation and direct sublimation (SSC-DS) method and their physical properties were investigated. The reaction yields and product stability were significantly affected by the identity of the diamine and anhydride substituents. On the other hand, the substituents of the benzimidazole ring allowed fine tuning of the emission maxima, fluorescence quantum yields, and redox potentials. The HOMO-LUMO levels were estimated by cyclic voltammetry in film on indium tin oxide (ITO) and compared with values obtained by other methods. The described benzimidazoles showed high crystallinity, which is attributed to a high planarity and interactions between carbon and heteroatoms. These compounds showed n-type semiconducting behavior in organic field-effect transistors (OFETs). Optimized devices for fluorinated NTCBI (naphthalene tetracarboxylic bisbenzimidazole) showed respectable electron mobilities of ∼10(-2) cm(2) V(-1) s(-1) .
Association of type II cAMP-dependent protein kinase with p34cdc2 protein kinase in human fibroblasts. (1991)

Previous independent studies suggested that type II cAMP-dependent protein kinase and the p34cdc2 protein kinase cell cycle regulator co-localize at centrosomes. In order to investigate whether there is an association of type II cAMP-dependent protein kinase with p34cdc2 in human fibroblasts, we used three different approaches. First, the regulatory subunits RI and RII were photoaffinity-labeled with 8-N3-[32P]cAMP, and anti-p34cdc2 immunoprecipitates were screened for the presence of either RI or RII regulatory subunits by one- or two-dimensional gel electrophoresis. Second, anti-RII alpha immunoprecipitates were screened for the presence of p34cdc2 by Western blot using three different affinity-purified antibodies recognizing different domains of human p34cdc2. Conversely, anti-p34cdc2 immunoprecipitates (three different antibodies), as well as the material retained on p13suc1-Sepharose Bio-Beads, which binds specifically p34cdc2, were screened for the presence of RII alpha. Finally, we have looked for cAMP-dependent protein kinase activity specifically inhibited by PKI in immunoprecipitates obtained from extracts treated with different anti-p34cdc2 antibodies. All these experiments gave concordant results and demonstrate that at least at G0/G1, human fibroblasts contain a complex of active type II cAMP-dependent protein kinase associated through its RII alpha subunit with p34cdc2.
<i>Understanding Molecular Simulation: From Algorithms to Applications</i> (1997)

Second and revised edition 

Understanding Molecular Simulation: From Algorithms to Applications explains the physics behind the recipes of molecular simulation for materials science. Computer simulators are continuously confronted with questions concerning the choice of a particular technique for a given application. A wide variety of tools exist, so the choice of technique requires a good understanding of the basic principles. More importantly, such understanding may greatly improve the efficiency of a simulation program. The implementation of simulation methods is illustrated in pseudocodes and their practical use in the case studies used in the text.

Since the first edition only five years ago, the simulation world has changed significantly -- current techniques have matured and new ones have appeared. This new edition deals with these new developments; in particular, there are sections on:

· Transition path sampling and diffusive barrier crossing to simulaterare events
· Dissipative particle dynamic as a course-grained simulation technique
· Novel schemes to compute the long-ranged forces
· Hamiltonian and non-Hamiltonian dynamics in the context constant-temperature and constant-pressure molecular dynamics simulations
· Multiple-time step algorithms as an alternative for constraints
· Defects in solids
· The pruned-enriched Rosenbluth sampling, recoil-growth, and concerted rotations for complex molecules
· Parallel tempering for glassy Hamiltonians

Examples are included that highlight current applications and the codes of case studies are available on the World Wide Web. Several new examples have been added since the first edition to illustrate recent applications. Questions are included in this new edition. No prior knowledge of computer simulation is assumed.
Bi-Directional Vector Variable Gain Amplifier for an X-Band Phased Array Radar Application (2023)

This thesis presents the design, layout, and measurements of a bi-directional amplifier with variable vector (in-phase / quadrature) gain control that will be part of an electronically steered phased array system. The electronically steered phased array has many advantages over the conventional mechanically steered antennas including rapid scanning of the beam and adaptively creating nulls in desired locations. The 10-bit bi-directional Vector Variable Gain Amplifier (VVGA) is part of the transmit and receive module of each antenna element where transmit and receive functionality is determined through a simple switch. The VVGA performs amplification of the IF IQ pair by an adjustable complex coefficient. At receive, the VVGA functions as a Vector Variable Gain Current Amplifier (VVGCA) and at transmit, the VVGA functions as a Vector Variable Gain Transadmittance Amplifier (VVGTA). Design procedure, layout entry, schematic and parasitic extracted simulation results, and measurements are presented in this thesis.
Explicit CSI Feedback Design for 5G New Radio phase II. (2018)

Massive multiple input multiple output (MIMO) systems are expected to boost the data throughput and reliability in future 5G systems. In order to enable advanced radio concepts in New Radio (NR) phase II, such as multiple transmit receive point (multi-TRP) transmission, accurate channel state information (CSI) knowledge at gNB side is essential. This paper provides a practical explicit CSI feedback scheme, which exploits time domain channel sparsity. A heuristic greedy algorithm is used to discover the channel support and feed it back to the gNB. Simulation results comparing the proposed approach against recently standardized NR phase I Type II CSI feedback, show an improved performance for the proposed design.
Balanced puff valve for imploding gas-puff experiments (1986)

The design of a fast-acting high-pressure puff valve for use in imploding gas-puff experiments is presented. By using a pressure-balanced valve design, the valve can operate at pressures up to 500 psia. Fast opening (≊200 μs) is achieved by using a fast-moving sliding hammer to open the valve. Balanced valves as well as fast-opening valves using sliding hammers are both well-known technologies; however, this design is the first one to incorporate both features in a single design resulting in a fast-acting high-pressure puff valve.
Gadodiamide and Dentate Nucleus T1 Hyperintensity in Patients With Meningioma Evaluated by Multiple Follow-Up Contrast-Enhanced Magnetic Resonance Examinations With No Systemic Interval Therapy (2015)

The dentate nucleus of the cerebellum may appear as hyperintense on unenhanced T1 magnetic resonance images (MRIs) of the brain. Recently, T1 signal hyperintensity has received attention owing to data on the association of this finding with the history of multiple injections of gadolinium-based contrast agents, specifically gadodiamide, in patients with multiple sclerosis and brain metastases. We conducted a retrospective study on patients with a meningioma who had routinely undergone follow-up enhanced MRI scans with gadodiamide. Across a time interval of 18 months (from January 2013 to July 2014), we identified 102 consecutive patients eligible for this study. A significant increase in T1 hyperintensity of the dentate nuclei of the cerebellum on nonenhanced scans was observed between the first and the last MRI in the group of patients with a history of at least 6 enhanced MRI scans (P < 0.01), whereas no differences were observed in the group with 1 to 5 enhanced MRI scans (P = 0.74). Further research is necessary to shed light on the mechanism of the T1 hyperintensity as well as on the histological and microstructural appearance of the dentate nucleus after multiple intravenous injections of gadodiamide. The finding raises the question of substantial dechelation of this agent in patients with normal renal function.
Focal-Plane Spatially Oversampling CMOS Image Compression Sensor (2007)

Image compression algorithms employ computationally expensive spatial convolutional transforms. The CMOS image sensor performs spatially compressing image quantization on the focal plane yielding digital output at a rate proportional to the mere information rate of the video. A bank of column-parallel first-order incremental DeltaSigma-modulated analog-to-digital converters (ADCs) performs column-wise distributed focal-plane oversampling of up to eight adjacent pixels and concurrent weighted average quantization. Number of samples per pixel and switched-capacitor sampling sequence order set the amplitude and sign of the pixel coefficient, respectively. A simple digital delay and adder loop performs spatial accumulation over up to eight adjacent ADC outputs during readout. This amounts to computing a two-dimensional block matrix transform with up to 8times8-pixel programmable kernel in parallel for all columns. Noise shaping reduces power dissipation below that of a conventional digital imager while the need for a peripheral DSP is eliminated. A 128times128 active pixel array integrated with a bank of 128 DeltaSigma-modulated ADCs was fabricated in a 0.35-mum CMOS technology. The 3.1 mm times 1.9-mm prototype captures 8-bit digital video at 30 frames/s and yields 4 GMACS projected computational throughput when scaled to HDTV 1080i resolution in discrete cosine transform (DCT) compression
Termination of lifespan of SV40‐transformed human fibroblasts in crisis is due to apoptosis (2002)

Normal human fibroblasts in culture have a limited lifespan, ending in replicative senescence. Introduction of SV40 sequences encoding large T antigen and small t antigen into pre-senescent cells results in an extension of lifespan for an additional 20-30 population doublings. Rare clones of SV40-transformed cells are capable of indefinite growth and are described as immortal; however, the great majority of SV40-transformed cells terminate this extended lifespan in cell death, termed "crisis." We have examined the properties of cells in crisis to obtain further insights into mechanism of cell death and immortalization. Populations at the terminal cell passage show a balance between cell replication and cell death over a period of several weeks, with a progressive increase in cells undergoing cell death. During this period, there is less than a 3-fold increase in attached cell number, with two stages being identifiable on the basis of the focal pattern of cell survival. We also demonstrate that cells in crisis are undergoing apoptosis based on TUNEL assay, subG1 DNA content, annexin V reactivity, and activation of caspases 3 and 8. We suggest a model whereby SV40-transformed cells acquire increased sensitivity to apoptosis based on changes in properties which activate caspase 8 in addition to changes previously described involving shortening of telomeric sequences. While only telomere stabilization could be clearly shown to be essential for survival of cells through crisis, the extended period of cell replication and altered gene expression observed in SV40-transformed cells during crisis are compatible with other genetic alterations in immortal cells.
Atom Probe Tomography for 3D-dopant analysis in FinFET devices (2012)

As the nano scale device performance depends on the detailed engineering of the dopant distribution, advanced doping processes are required. Progressing towards 3D-structures like FinFETs, studying the dopant gate overlap and conformality of doping calls for metrology with 3D-resolution and the ability to confine the analyzed volume to a small 3D-structure. We demonstrate that through an appropriate methodology this is feasible using Atom Probe Tomography (APT). We extract the 3D-dopant profile and important parameters such as gate overlap and profile steepness, from transistor formed with plasma doping processes. Analyzing samples with different doping processes, the APT results are entirely consistent with device performances (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> vs. I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> ).
The three-dimensional structure of a glutathione S-transferase from the Mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-.ANG. resolution (1992)

The crystal structure of a mu class glutathione S-transferase (EC 2.5.1.18) from rat liver (isoenzyme 3-3) in complex with the physiological substrate glutathione (GSH) has been solved at 2.2-A resolution by multiple isomorphous replacement methods. The enzyme crystallized in the monoclinic space group C2 with unit cell dimensions of a = 87.98 A, b = 69.41 A, c = 81.34 A, and beta = 106.07 degrees. Oligonucleotide-directed site-specific mutagenesis played an important role in the solution of the structure in that the cysteine mutants C86S, C114S, and C173S were used to help locate the positions of mercuric ion sites in nonisomorphous derivatives with ethylmercuric phosphate and to align the sequence with the model derived from MIR phases. A complete model for the protein was not obtained until part of the solvent structure was interpreted. The dimer in the asymmetric unit refined to a crystallographic R = 0.171 for 19,298 data and I > or = 1.5 sigma (I). The final model consists of 4150 atoms, including all non-hydrogen atoms of 434 amino acid residues, two GSH molecules, and oxygen atoms of 474 water molecules. The dimeric enzyme is globular in shape with dimensions of 53 x 62 x 56 A. Crystal contacts are primarily responsible for conformational differences between the two subunits which are related by a noncrystallographic 2-fold axis. The structure of the type 3 subunit can be divided into two domains separated by a short linker, a smaller alpha/beta domain (domain I, residues 1-82), and a larger alpha domain (domain II, residues 90-217). Domain I contains four beta-strands which form a central mixed beta-sheet and three alpha-helices which are arranged in a beta alpha beta alpha beta beta alpha motif. Domain II is composed of five alpha-helices. Domain I can be considered the glutathione binding domain, while domain II seems to be primarily responsible for xenobiotic substrate binding. The active site is located in a deep (19-A) cavity which is composed of three relatively mobile structural elements: the long loop (residues 33-42) of domain I, the alpha 4/alpha 5 helix-turn-helix segment, and the C-terminal tail. GSH is bound at the active site in an extended conformation at one end of the beta-sheet of domain I with its backbone facing the cavity and the sulfur pointing toward the subunit to which it is bound.(ABSTRACT TRUNCATED AT 400 WORDS)
On acoustic particle and cell manipulation in microfluidic systems (2007)

The combination of laminar flows in microfabricated channels and acoustic forces induced in ultrasonic standing wave fields offers new possibilities for advanced particle and cell manipulation in lab-on-a-chip applications as well as in relatively high throughput applications. Acoustic particle manipulation systems can be used e.g. to separate, wash, sort, trap or distribute particles in microfluidic networks. This doctoral thesis starts by reviewing the fundamental fields of study needed to realize such systems and to understand their potential impact. Next, the design, fabrication, operation and performance of a number of systems, based on system design principle termed the "Lund method", are described. The developed methods comprise a toolbox of generic particle handling methods that can be combined or used separately to handle biological and non-biological particles in liquid suspension. The toolbox is applied to solve various blood component handling tasks, e.g. separation of lipid particles and other contaminating substances from red blood cells and preparation of blood components. The results imply that it is possible to save thousands of people from brain damage caused by lipid particles each year, to reduce the strain on the blood banks significantly and to offer new methods for routine blood component handling. Several other important areas of application, where micrometer sized particles are routinely handled, can also be identified. Microscale acoustic particle manipulation technology is still in its infancy but, based on the findings presented in this thesis and by other researchers, it can be anticipated that new laboratory and industrial standards may very well emerge from the current research.
Fine-grained dynamic voltage and frequency scaling for precise energy and performance trade-off based on the ratio of off-chip access to on-chip computation times (2004)

This paper presents an intra-process dynamic voltage and frequency scaling (DVFS) technique targeted toward non real-time applications running on an embedded system platform. The key idea is to make use of runtime information about the external memory access statistics in order to perform CPU voltage and frequency scaling with the goal of minimizing the energy consumption while translucently controlling the performance penalty. The proposed DVFS technique relies on dynamically-constructed regression models that allow the CPU to calculate the expected workload and slack time for the next time slot, and thus, adjust its voltage and frequency in order to save energy while meeting soft timing constraints. This is in turn achieved by estimating and exploiting the ratio of the total off-chip access time to the total on-chip computation time. The proposed technique has been implemented on an XScale-based embedded system platform and actual energy savings have been calculated by current measurements in hardware. For memory-bound programs, a CPU energy saving of more than 70% with a performance degradation of 12% was achieved. For CPU-bound programs, 15/spl sim/60% CPU energy saving was achieved at the cost of 5-20% performance penalty.
Method of upgrading oils containing hydroxyaromatic hydrocarbon compounds to highly aromatic gasoline (2023)

The present invention is a multi-stepped method of converting an oil which is produced by various biomass and coal conversion processes and contains primarily single and multiple ring hydroxyaromatic hydrocarbon compounds to highly aromatic gasoline. The single and multiple ring hydroxyaromatic hydrocarbon compounds in a raw oil material are first deoxygenated to produce a deoxygenated oil material containing single and multiple ring aromatic compounds. Then, water is removed from the deoxygenated oil material. The next step is distillation to remove the single ring aromatic compouns as gasoline. In the third step, the multiple ring aromatics remaining in the deoxygenated oil material are cracked in the presence of hydrogen to produce a cracked oil material containing single ring aromatic compounds. Finally, the cracked oil material is then distilled to remove the single ring aromatics as gasoline.
Dielectric Resonators With High $Q$-Factor for Tunable Low Phase Noise Oscillators (2013)

This paper demonstrates the realization of tunable microwave low phase noise oscillators. A ceramic-based dielectric resonator enclosed in a metallic cavity with an unloaded <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> of 13000 is proposed. The relationship between geometric parameters and resonant frequency is determined. The dielectric puck is then incorporated into multilayer printed circuit boards by using substrate-integrated waveguide techniques. The results show that the resonator resonates at TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01δ</sub> mode with a frequency of 13.3 GHz. Therefore, 13.3 GHz dielectric resonator oscillators with both mechanic and electronic tuning are built. The oscillator includes a pseudomorphic high-electron-mobility transistor low-noise amplifier and an electronic phase shifter. The measured phase noise of the oscillator is -121.7 dBc/Hz at a 10-kHz offset. The calculated and measured phase noise results show a difference of 3 dB.
Paired electrolysis of 5-(hydroxymethyl)furfural in flow cells with a high-performance oxide-derived silver cathode (2021)

Paired electrolysis of HMF in a flow cell markedly reduces cell voltage and realizes co-production of BHMF and FDCA.