gebhart/patrepeval huggingface dataset:
Separation of light gas mixtures using SAPO‐34 membranes (2000)

Abstract Continuous SAPO‐34 membranes were prepared on porous alumina tubular supports, and shown to be useful for light gas separations at low and high temperatures. Single‐gas permeances of CO 2 , N 2 and CH 4 decreased with increasing kinetic diameter. For the best membrane at 300 K, the He and H 2 permeances were less than that of CO 2 , because He, H 2 , and CO 2 were small compared to the SAPO‐34 pore, and differences in the heat of adsorption determined the permeance order. The smaller component permeated the fastest in CO 2 /CH 4 , CO 2 /N 2 , N 2 /CH 4 , H 2 /CH 4 and H 2 /N 2 mixtures between 300 and 470 K. For H 2 /CO 2 mixtures, which were separated by competitive adsorption at room temperature, the larger component permeated faster below 400 K. The CO 2 /CH 4 selectivity at room temperature was 36 and decreased with temperature. The H 2 /CH 4 mixture selectivity was 8 and constant with temperature up to 480 K. Calcination, slow temperature cycles, and exposure to water vapor had no permanent effect on membrane performance, but temperature changes of approximately 30 K/min decreased the membrane's effectiveness.
Mechanism Based Inhibition of Hydroxysteroid Dehydrogenases (1991)

Steroid hormone action can be regulated not only at the receptor level but also by the enzymes that are responsible for the synthesis and degradation of biologically active steroids. Traditionally the pharmacological intervention of steroid hormone action has focused on the development of steroidal and nonsteroidal hormone receptor agonists and antagonists with appropriate pharmacokinetics. Recently, the development of selective inhibitors/inactivators of steroid metabolizing enzymes has gained momentum. This review will concentrate on the development of mechanism-based inhibitors for one class of steroid hormone transforming enzymes, the hydroxysteroid dehydrogenases.
ChemInform Abstract: (2‐EXO‐3‐ENDO)‐2‐ARYLTROPANE‐3‐CARBOXYLIC ESTERS, A NEW CLASS OF NARCOTIC ANTAGONISTS (1979)

Abstract Die Grignard‐Verbindungen (II) reagieren mit dem ungesättigten Carbonsäure ester (1) zu den gesättigten Carbonsäureestern (III) und (IV), wobei durch Einhaltung der Reaktionstemperatur von ‐20 bis ‐25°C und durch Verwendung von Ether anstelle von Tetrahydrofuran eine weitere Reaktion von (II) mitden Primäraddukten weitgehend vermieden wird.
A novel phase-shifterless beam steering method for RF phase arrays using monolithic 1-D coupled-VCOs with integrated MOSFET switches (2010)

A fully monolithic 1-Dimensional (1-D) AC-coupled Voltage-Controlled-Oscillators (VCOs) network design for phased-array applications will be presented in this paper. This radio-frequency (RF) VCO array integrates on-chip inductors, varactors, and bias current sources and it contains an odd number of VCOs (i.e., 3 or 5, etc.) AC-coupled through on-chip switchable resistor networks with MOSFETs. Realistic circuit simulations in IBM 7HP 0.18μm BiCMOS design kit indicate promising results of the 1-D coupled-VCO array. Based on the simulation data and the current measured data that has been consistent with the simulation results, our design is able to control the phasing of this on-chip VCO-array by means of tuning the edge elements and/or by varying the coupling strength via the resistive coupling network digitally controlled with the MOS switches. This AC-coupled 1-D VCO array shows some great potential for RF active antennas applications to perform wide angle beam steering without the need for bulky phase shifters for the highly utilized S-band.
2-(6-Carboxyhexyl)cyclopentanone hexylhydrazone. A potent and time-dependent inhibitor of platelet aggregation (1983)

Two new azaprostanoids, a hydrazone (3) and hydrazide (4), have been prepared by the condensation of 2-(6-carboxyhexyl)cyclopentanone with n-hexylhydrazine and caproic acid hydrazide. Preliminary results with the stable hydrazide 4 indicate that it inhibits arachidonic acid (AA) induced human platelet aggregation and that, unlike 13-azaprostanoic acid (1), its site of action is at the cyclooxygenase level. Results with the unstable hydrazone derivative 3 indicate it to be a potent and time-dependent inhibitor of AA-induced human platelet aggregation, with its site of action also at the cyclooxygenase level.
Novel MIPs-Parabens based SPE Stationary Phases Characterization and Application (2019)

In this work, the synthesis, characterization, and application of novel parabens imprinted polymers as highly selective solid-phase extraction (SPE) sorbents have been reported. The imprinted polymers were created using sol-gel molecular imprinting process. All the seven parabens were considered herein in order to check the phase selectivity. By means of a validated HPLC-photodiode array detector (PDA) method all seven parabens were resolved in a single chromatographic run of 25 min. These SPE sorbents, <i>in-house</i> packed in SPE empty cartridges, were first characterized in terms of extraction capability, breakthrough volume, retention volume, hold-up volume, number of theoretical plates, and retention factor. Finally, the device was applied to a real urine sample to check the method feasibility on a very complex matrix. The new paraben imprinted SPE sorbents, not yet present in the literature, potentially encourage the development of novel molecularly imprinted polymers (MIPs) to enhance the extraction efficiency, and consequently the overall analytical performances, when the trace quantification is required.
Upgrading of delayed and fluid cokes from oil sand by desulfurization (1982)

Abstract Calcination of delayed and fluid oil sand cokes with alkaline reagents at high sodium/sulfur ratios followed by leaching gave almost complete desulfurization in terms of gaseous combustion products. Use of smaller proportions of alkaline reagents with hydrodesulfurization at 650 to 850°C also resulted in extensive removal of sulfur as hydrogen sulfide.
Performance driven BIST technique for random logic (2002)

Performance degradation due to insertion of BIST logic into high-speed designs has been analyzed. A framework to introduce BIST into random logic circuits, without causing timing violations has been proposed. Various heuristics for selecting flip-flops for BIST have been developed and studied in detail. Experimental results indicate an improvement in performance while optimizing fault coverage and area overhead.
Mid-Infrared Interband Cascade Lasers Operating CW at Room Temperature (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. W. Bewley, C. L. Canedy, C. S. Kim, M. Kim, J. R. Lindle, J. Abell, I. Vurgaftman, and J. R. Meyer, "Mid-Infrared Interband Cascade Lasers Operating CW at Room Temperature," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper CThAA6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Novel applications of photonic band gap materials: Low-loss bends and high <i>Q</i> cavities (1994)

In this paper we discuss a novel material which has nearly ideal properties at optical frequencies. It combines the low dissipation of a dielectric with the reflectivity of a metal. This material employs a two-dimensional photonic band gap structure to achieve in-plane confinement of light and uses index contrast to achieve vertical confinement. We discuss how this material can be used to create microcavities for the production of low threshold lasers and waveguides capable of low-loss bends.
Refractive index perturbations in optical fibers resulting from frozen-in viscoelasticity (2003)

We show that frozen-in viscoelasticity has a significant impact on the refractive index profile of optical fibers. Viscoelastic strains can be frozen into an optical fiber during draw, or by cooling down a drawn fiber from its fictive temperature while under tension. The resulting refractive index perturbation is concentrated in the highest viscosity region of the fiber, exhibits minimal birefringence, and can significantly alter critical performance characteristics. Our quantitative theory for the refractive index perturbation is in excellent agreement with measured data. Frozen-in viscoelasticity can also be harnessed to serve as the basis for optical fiber devices.
The addition of exogenous gangliosides to cultured human cells results in the cell type-specific expression of novel surface antigens by a biosynthetic process. (1989)

After the observation that human mAb 32-27M reacts only with melanoma and astrocytoma cells cultured in the presence of fetal bovine serum, a novel pathway for the uptake of exogenous gangliosides, their further biosynthesis, and expression at the cell surface as novel Ag has been elucidated. The addition of fetal bovine serum to melanoma and astrocytoma cells growing in synthetic medium (insulin-transferrin-selenium) resulted in reactivity with Ab32-27M. As antibody 32-27M detects N-glycolylneuraminic acid (NeuGc)-containing gangliosides, the effect of adding a number of different gangliosides to melanoma and astrocytoma cells cultured in the synthetic medium was studied. Only the addition of NeuGc-GM3 resulted in the development of Ab32-27M reactivity. The identity of the antigenic structures developed after addition of fetal bovine serum or NeuGc-GM3 was determined by analysis of the gangliosides from both samples. The major component detected in melanoma cell lines was shown to be N-acetylneuraminic acid-NeuGc-GD3. Another, slower moving component, present in some melanomas and in astrocytomas may be N-acetylneuraminic acid-NeuGc-GD2. The cell type specificity for these processes can be most readily explained by postulating that all cells can take up exogenous gangliosides but only melanoma and astrocytoma cells have sufficiently high levels of GM3 alpha 2----8-sialyltransferase for the conversion of added NeuGc-GM3 to disialogangliosides to be effective. These results demonstrate a novel pathway for exogenous glycolipid processing that can lead to novel Ag expression but may also play a role in normal glycolipid metabolism and function.
Open transport switch (2013)

There have been a lot of proposals to unify the control and management of packet and circuit networks but none have been deployed widely. In this paper, we propose a simple programmable architecture that abstracts a core transport node into a programmable virtual switch, that meshes well with the software-defined network paradigm while leveraging the OpenFlow protocol for control. A demonstration use-case of an OpenFlow-enabled optical virtual switch implementation managing a small optical transport network for big-data applications is described. With appropriate extensions to OpenFlow, we discuss how the programmability and flexibility SDN brings to packet-optical backbone networks will be substantial in solving some of the complex multi-vendor, multi-layer, multi-domain issues service providers face today.
SecureML: A System for Scalable Privacy-Preserving Machine Learning. (2017)

Machine learning is widely used in practice to produce predictive models for applications such as image processing, speech and text recognition. These models are more accurate when trained on large amount of data collected from different sources. However, the massive data collection raises privacy concerns. In this paper, we present new and efficient protocols for privacy preserving machine learning for linear regression, logistic regression and neural network training using the stochastic gradient descent method. Our protocols fall in the two-server model where data owners distribute their private data among two non-colluding servers who train various models on the joint data using secure two-party computation (2PC). We develop new techniques to support secure arithmetic operations on shared decimal numbers, and propose MPC-friendly alternatives to non-linear functions such as sigmoid and softmax that are superior to prior work. We implement our system in C++. Our experiments validate that our protocols are several orders of magnitude faster than the state of the art implementations for privacy preserving linear and logistic regressions, and scale to millions of data samples with thousands of features. We also implement the first privacy preserving system for training neural networks.
ChemInform Abstract: TETRAETHYL 4‐(3‐NITROPHENYL)‐2,3,5,6‐PYRIDINETETRACARBOXYLATE (1976)

Abstract 3‐Nitrobenzaldehyd (I) liefert mit Ketobernsteinsäureester (II) das Bis‐Kondensat (III), das mit Ammonacetat zum Dihydropyridin (IV) cyclisiert und dann mit Salpetersäure zu (V) oxidiert wird.
Mosaicing on adaptive manifolds (2000)

Image mosaicing is commonly used to increase the visual field of view by pasting together many images or video frames. Existing mosaicing methods are based on projecting all images onto a predetermined single manifold: A plane is commonly used for a camera translating sideways, a cylinder is used for a panning camera, and a sphere is used for a camera which is both panning and tilting. While different mosaicing methods should therefore be used for different types of camera motion, more general types of camera motion, such as forward motion, are practically impossible for traditional mosaicing. A new methodology to allow image mosaicing in more general cases of camera motion is presented. Mosaicing is performed by projecting thin strips from the images onto manifolds which are adapted to the camera motion. While the limitations of existing mosaicing techniques are a result of using predetermined manifolds, the use of more general manifolds overcomes these limitations.
Synthesis and Structure Determination by ZEFSAII of SSZ-55:  A New High-Silica, Large-Pore Zeolite (2001)

The synthesis, structure solution, and characterization of the high-silica zeolite SSZ-55 are described. SSZ-55 was synthesized under hydrothermal conditions using a [(1-(3-fluorophenyl)cyclopentyl)methyl]trimethylammonium cation as the structure-directing agent. The framework topology and symmetry of SSZ-55 were determined by the Monte Carlo method ZEFSAII. Rietveld refinement of the X-ray powder diffraction data confirms the space group assignment of Cmc21. Transmission electron microscopy confirms the unit cell parameters and the topology of the structure. SSZ-55 contains one-dimensional pores circumscribed by 12 T-atom rings. The topology of SSZ-55 is that of the ATS framework, previously described for AlPO-based molecular sieves.
Extended-range optical low-coherence reflectometry using a recirculating delay technique (1993)

We propose a novel technique allowing for a substantial increase in the distance measurement range for optical low-coherence reflectometry. By introducing a recirculating delay into the interferometer reference path, we achieve a 100 times increase in range compared to previous optical low-coherence reflectometry techniques. At this extended range, a reflection sensitivity greater than -80 dB is demonstrated at a probe wavelength of 1.55 mu m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: CARBOCYCLIC THROMBOXANE A2 (1980)

Abstract Die Totalsynthese der Titelverbindung α‐(Xc) und seines Hydroxyepimeren β (Xc) wird sowohl in racemischer sowie in optisch aktiver Form durchgeführt.
Structure, Expression, and Function of Human Pituitary Tumor-Transforming Gene (PTTG) (1999)

Despite advances in characterizing the pathophysiology and genetics of pituitary tumors, molecular mechanisms of their pathogenesis are poorly understood. Recently, we isolated a transforming gene [pituitary tumor-transforming gene (PTTG)] from rat pituitary tumor cells. Here we describe the cloning of human PTTG, which is located on chromosome 5q33 and shares striking sequence homology with its rat counterpart. Northern analysis revealed PTTG expression in normal adult testis, thymus, colon, small intestine, brain, lung, and fetal liver, but most abundant levels of PTTG mRNA were observed in several carcinoma cell lines. Stable transfection of NIH 3T3 cells with human PTTG cDNA caused anchorage-independent transformation in vitro and induced in vivo tumor formation when transfectants were injected into athymic mice. Overexpression of PTTG in transfected NIH 3T3 cells also stimulated expression and secretion of basic fibroblast growth factor, a human pituitary tumor growth-regulating factor. A proline-rich region, which contains two PXXP motifs for the SH3 domain-binding site, was detected in the PTTG protein sequence. When these proline residues were changed by site-directed mutagenesis, PTTG in vitro transforming and in vivo tumor-inducing activity, as well as stimulation of basic fibroblast growth factor, was abrogated. These results indicate that human PTTG, a novel oncogene, may function through SH3-mediated signal transduction pathways and activation of growth factor(s).
Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases (2004)

Using a high-throughput screening strategy, a series of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones was identified that inhibit the cyclin-dependent kinase (CDK) 4/cyclin D1 complex-mediated phosphorylation of a protein substrate with IC(50)s in the low micromolar range. On the basis of preliminary structure-activity relationships (SAR), a model was proposed in which these inhibitors occupy the ATP-binding site of the enzyme, forming critical hydrogen bonds to the same residue (Val96) to which the amino group in ATP is presumed to bind. X-ray diffraction studies on a later derivative bound to CDK2 support this binding mode. Iterative cycles of synthesis and screening lead to a novel series of potent, CDK2-selective 6-(arylmethyl)pyrazolopyrimidinones. Placement of a hydrogen-bond donor in the meta-position on the 6-arylmethyl group resulted in approximately 100-fold increases in CDK4 affinity, giving ligands that were equipotent inhibitors of CDK4 and CDK2. These compounds exhibit antiproliferative effects in the NCI HCT116 and other cell lines. The potency of these antiproliferative effects is enhanced in anilide derivatives and translates into tumor growth inhibition in a mouse xenograft model.
Antitumor septacidin analogs (1977)

In the first approach by total synthesis to the structure of the antitumor antibiotic septacidin, analogues have been obtained which show similar inhibition of RNA-DNA synthesis in cultured leukemia L1210 cells and similar activity against transplanted leukemia P388 in mice. In these analogues, the natural aminoheptose moiety is replaced by 4-amino-4-deoxy-and 4-amino-4,6-dideoxy-L-glucose, to retain the natural configuration of the pyranose ring. Also retained is the lipophilic fatty acid-amino acid side chain attached to the 4-amino group and glycosylation at the 6-NH2 of adenine. If the fatty acid chain was shortened from C16 to C6, if the fatty chain was shifted to the glycine unit, or if the glycine unit was omitted, activity was completely lost. However, activity was retained if the C16 chain was shortened only to C12 or if the glycine unit was extended to beta-alanine. Both active and inactive analogues were nonbinding to DNA and nonmutagenic to Salmonella strains. The synthetic approach was to start with a suitably protected sugar (L-fucose and L-galactose), construct the adenine moiety at C-1 introduce a 4-amino group, and finally attach the preformed side chain.
Utilization of laser interstitial thermotherapy guided by real-time thermal MRI as an alternative to separation surgery in the management of spinal metastasis (2015)

The authors present the first report on an innovative minimally invasive alternative to surgery in the management of spinal metastasis. In their early experience, SLITT has provided local control with low morbidity and improvement in both pain and the quality of life of patients.
Anaerobic biodegradation of long chain fatty acids : a review (2005)

If an effluent with high lipid content is fed to a continuous high rate anaerobic digester, a significant accumulation of Long Chain Fatty Acids (LCFA) onto the sludge aggregates (flocs or granules) is observed, without further mineralization to methane. That accumulation is progressive and, after some time, the sludge becomes surrounded by whitish foam and tends to float, leading, most of times, to a severe washout. This happens not only with granular sludge reactors, but also with fixed bed reactors. This fact, associated to the accepted idea that LCFA were highly toxic to the anaerobic consortia, imposed that lipids had to be removed from any wastewater before the anaerobic treatment step. Therefore, the high methane potential of these compounds was lost. However, it was observed that anaerobic sludge had the capacity to mineralize the LCFA associated to the cells by mechanisms of adsorption, precipitation or entrapment. The mineralization of these biomass-associated LCFA was inhibited by oleic acid present in the feed. Furthermore, after the mineralization of these biomass-associated LCFA, the specific methanogenic activity of the sludge was enhanced, being able to accumulate and mineralize a new LCFA load. These facts contradict the accepted theories about the severe and irreversible toxicity of LCFA and clearly suggest that only a reversible inhibition occurs, probably a simple physical transport limitation effect. The main practical result of this research is that a sequencing batch reactor (SBR) based process will be the most suitable way to efficiently mineralize effluents with high lipids content. The new SBR concept is under development and was recently awarded with the Lettinga Award 2004. A review of the most important results on anaerobic LCFA biodegradation is presented in this paper.
Aqueous Organic Redox Flow Batteries (AORFBs) for Sustainable and Safe Renewable Energy Storage (2017)

The presentation will cover my group research efforts in developing high performance aqueous organic redox flow batteries (AORFBs) aiming for sustainable and economical large-scale energy storage from solar and wind. We have pioneered the development of novel AORFBs employing water-soluble redox active molecules including viologen, ferrocene, and TEMPO. [1-4] Particularly, the chemistry and battery performance of the FcNCl / MV AORFB will be discussed in detail, [1] where FcNCl is (ferrocenylmethyl)trimethylammonium chloride and MV is methyl viologen dichloride. Challenges and advances in developing AORFBs for practical applications will be discussed. How chemistry plays crucial roles in developing the new generations of redox flow batteries will be emphasized. References: (1) Hu, B.; DeBruler C., Rhodes, Z.; Liu, T. L.* , J. Amer. Chem. Soc. , 2017 ,139, 1207. (2) Liu, T. ;* Wei, X.; Nie, Z.; Vince, S.; Wang, W. Adv. Energy Mat . 2016. (3) Filed US Patents covering applications of water soluble viologen, ferrocene derivatives, and TEMPO for RFBs (4) Group website: www.tianbiaoliu.org