gebhart/patrepeval huggingface dataset:
Effect of aqueous ethanol washing on the physicochemical and functional properties of safflower (<i>Carthamus tinctorius</i>) seed proteins (1992)

Abstract Defatted safflower seed flour was deliganded by repeated extraction with 750 ml litre −1 ethanol. This reduced the colour/ligand concentration to less than 1% of the original concentration. As a result of this the protein concentration increased from 585 to 686 g kg −1 after deliganding. The proteins from the deliganded flour comprised four protein fractions, as observed from the gel filtration profile and sedimentation velocity pattern. However, the polyacrylamide gel electrophoretic pattern indicated six protein bands. Functional properties such as bulk density and water absorption capacity increased after deliganding. The fat absorption, emulsification and foaming properties showed a decreasing trend as a result of deliganding.
Lipopeptides containing 2-(palmitoylamino)-6,7-bis(palmitoyloxy)heptanoic acid: synthesis, stereospecific stimulation of B-lymphocytes and macrophages and adjuvanticity in vivo and in vitro (1991)

Lipopeptides, carrying the N-terminal lipoamino acid 2-(palmitoylamino)-6,7-bis(palmitoyloxy) heptanoic acid (Pam3Adh-OH, 1), were obtained by solid-phase synthesis and by synthesis in solution. 2-Amino-6,7-dihydroxyheptanoic acid (Adh) can be regarded as a methylene analogue of S-glycerylcysteine, the N-terminal amino acid of lipoprotein from the outer cell membrane of Escherichia coli (a methylene group substitutes for the sulfur atom). The lipopeptides Pam3Adh-Ser-Ser-Asn-Ala 2a-d, in which the four possible stereoisomers of Pam3Adh-OH (2S,6S)-1 (1a), (2S,6R)-1 (1b), (2R,6S)-1 (1c), and (2R,6R)-1 (1d) are linked to the naturally occurring sequence Ser-Ser-Asn-Ala of the N-terminus of lipoprotein, and also Pam3Adh-Ser-(Lys)4 [2S,6S)-3), with a peptide part rendering the molecule water soluble, were capable of stimulating murine splenocytes polyclonally in vitro, as determined in a proliferation assay and in a hemolytic plaque assay against trinitrophenylated sheep erythrocytes. The diastereomers (2S,6S)-2 and (2R,6S)-2 with S-configurated C-6 were more active than the diastereomers (2S,6R)-2 and (2R,6R)-2 with R-configurated C-6; a change of the configuration at C-2 had less effect on the stimulatory activity. (2S,6S)-2 and (2S,6S)-3 are potent immunoadjuvants. A significantly enhanced primary immune response against trinitrophenylated sheep erythrocytes was obtained in vitro at lipopeptide concentrations of about 5 micrograms/mL and an immunization dose of 10(7) sheep erythrocytes/mL. Balb/c mice, which were immunized with a mixture of ovalbumin and (2S,6S)-2 or (2S,6S)-3, respectively, had a substantially higher antiovalbumin titer 28 days after immunization than mice which had received ovalbumin, (2S,6S)-2 or (2S,6S)-3 alone. Finally, the novel lipopeptides constitute potent macrophage activators: (2S,6S)-3 was able to induce tumor cytotoxicity against the tumor cell line L929 in bone marrow derived macrophages.
SYNTHESIS OF NANOSPHERICAL AND ULTRALONG FIBROUS HYDROXYAPATITE AND REINFORCEMENT OF BIODEGRADABLE CHITOSAN/HYDROXYAPATITE COMPOSITE (2009)

Morphologies of hydroxyapatite (HAp) powders have influence on the mechanical properties of HAp/polymer composites. In this paper we reported a synthetic route for nanospherical and ultralong fibrous HAp powders and compared the influence of HAp morphologies on composite mechanical properties. HAp fibers with the length of ~250 µm along c-axis direction and nanospheres with the diameter of ~80 nm were produced, respectively, in the acidic solution containing glutamic acid and in the alkaline solution containing polyacrylic acid. The ultralong HAp fibers synthesized were used to reinforce biodegradable chitosan biomaterials with the significant improvement of bending strength because of the pull-out effect of long fibers.
First clinical experience of a novel penetration catheter for patients with severe coronary artery stenosis (2005)

The study aimed to evaluate the efficacy of a novel penetration catheter for severe coronary artery disease. Severe coronary artery diseases such as chronic total occlusions or severe calcified stenoses sometimes obstruct the subsequent crossing of balloon catheter after successful wire crossing. A novel penetration over-the-wire catheter has been developed for severe coronary artery disease. The main shaft is a coreless stainless coil that consists of eight stranded stainless wires to cross through a severe stenosis by manual rotation. This device was applied during percutaneous coronary intervention for patients with severe coronary artery disease obstructing the subsequent crossing of balloon or microcatheters after successful wire crossing. Initial results were examined. Fourteen eligible patients were enrolled consecutively. Among those, 10 patients had chronic total occlusion and 7 patients showed severe angiographical calcification. The device was successfully crossed through the lesion and enabled subsequent dilatation in all patients without any complication. This new device enables the crossing of severe coronary artery stenoses and therefore favors further dilatation in this lesion subset.
Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate) (2008)

A biodegradable amphiphilic block copolymer, PEG-b-P(LA-co-MAC), was used to prepare spherical micelles consisting of a hydrophobic P(LA-co-MAC) core and a hydrophilic PEG shell. To improve their stability, the micelles were crosslinked by radical polymerization of the double bonds in the hydrophobic blocks. The crosslinked micelles had similar sizes and a narrow size distribution compared to their uncrosslinked precursor. The improved stability of the crosslinked micelles was confirmed by measurements of the CMC and a thermodynamic investigation. These micelles can internalize into Hela cells in vitro as demonstrated by inverted fluorescence microscopy and CLSM. These stabilized nanoscale micelles have potential use in biomedical applications such as drug delivery and disease diagnosis.
Detection of rare circulating breast cancer cells by filtration cytometry and identification by DNA content: sensitivity in an experimental model. (1997)

Current methods of detecting micrometastases in breast cancer fail in a large proportion of patients. Therefore an improved method for detection of metastases in blood samples could be of great clinical interest both for prognosis and selection of patients for adjuvant systemic therapy. We have developed a new non-invasive method which associates immuno-magnetic separation and filtration cytometry. The sensitivity of our procedure was evaluated in a model system using a mixture from a human breast cancer cell line (MCF-7) and a normal human blood sample. The identification of tumoral cells was achieved by measuring DNA content in comparison with standard cells. The lowest concentration of MCF-7 detected was 1 tumoral cell in 500,000 white blood cells. In addition, filtration cytometry provides a visual control of nuclei permitting the elimination of all doubtful cases and an automatic count of tumoral cells directly per ml of blood, which may be an independent predictor of early relapse. This new method may avoid unnecessary axillary lymph node dissection in patients with negative nodes. Our procedure seems suitable for the detection of rare circulating cells in routine laboratory testing and could be used in other applications.
Using Ada for PC-based software development (1991)

Article Free Access Share on Using Ada for PC-based software development Author: Charles R. Snyder Unisys Defense Systems, Inc., Camarillo, CA Unisys Defense Systems, Inc., Camarillo, CAView Profile Authors Info & Claims WADAS '91: Proceedings of the eighth annual Washington Ada symposium & summer SIGAda meeting on Ada: software: foundation for competitvenessJune 1991 Pages 1–9https://doi.org/10.1145/134494.134495Online:01 June 1991Publication History 0citation68DownloadsMetricsTotal Citations0Total Downloads68Last 12 Months1Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Secure genomic testing with size- and position-hiding private substring matching (2013)

Recent progress in genomics and bioinformatics is bringing complete and on-demand sequencing of human (and other) genomes closer and closer to reality. Despite exciting new opportunities, affordable and ubiquitous genome sequencing prompts some serious privacy and ethical concerns, owing to extreme sensitivity and uniqueness of genomic information. At the same time, new medical applications, such as personalized medicine, require testing genomes for specific markers that themselves represent sensitive (e.g., proprietary) material. This paper focuses on privacy challenges posed by such genetic tests. It presents a secure and efficient protocol called: Size- and Position-Hiding Private Substring Match- ing (SPH-PSM). This protocol allows two parties -- one with a digitized genome and the other with a set of DNA markers -- to conduct a test, such that the result is only learned by the former, and no other information is learned by either party. In particular, the genome owner does not even learn the size or the position of the markers, which makes SPH-PSM the first of its kind. Finally, we report on a prototype of the proposed technique which attests to its practicality.
Applications of tensor (multiway array) factorizations and decompositions in data mining (2011)

Abstract Tensor (multiway array) factorization and decomposition has become an important tool for data mining. Fueled by the computational power of modern computer researchers can now analyze large‐scale tensorial structured data that only a few years ago would have been impossible. Tensor factorizations have several advantages over two‐way matrix factorizations including uniqueness of the optimal solution and component identification even when most of the data is missing. Furthermore, multiway decomposition techniques explicitly exploit the multiway structure that is lost when collapsing some of the modes of the tensor in order to analyze the data by regular matrix factorization approaches. Multiway decomposition is being applied to new fields every year and there is no doubt that the future will bring many exciting new applications. The aim of this overview is to introduce the basic concepts of tensor decompositions and demonstrate some of the many benefits and challenges of modeling data multiway for a wide variety of data and problem domains. © 2011 John Wiley & Sons, Inc. WIREs Data Mining Knowl Discov 2011 1 24‐40 DOI: 10.1002/widm.1 This article is categorized under: Algorithmic Development > Scalable Statistical Methods Technologies > Classification Technologies > Machine Learning Technologies > Structure Discovery and Clustering
CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor. (1993)

Prior studies have suggested that protein kinase A (PKA)-mediated inhibition of the rabbit renal brush border membrane (BBM) Na(+)-H+ exchanger involves a regulatory protein that is distinct from the transporter. This putative regulatory protein was purified by column chromatography and SDS-PAGE, and a partial primary amino acid sequence was determined. An affinity-purified polyclonal antibody to a synthetic peptide representing a sequence of the protein recognized a polypeptide of 55 kD in BBM but not in basolateral membrane. The antibody immunoprecipitated a PKA substrate of a similar molecular mass from detergent-solubilized BBM proteins. When assayed after reconstitution, PKA in the presence of ATP and Mg2+ did not inhibit Na(+)-H+ exchange transport in a fraction of solubilized BBM proteins eluting from an anion exchange column between 0.2 and 0.4 M NaCl (fraction B). Coreconstitution of fraction B with the immunoprecipitated 55-kD protein restored the inhibitory effect of PKA (change = 42%, P < 0.05). By contrast, Na(+)-H+ exchange transport in total solubilized BBM proteins was inhibited 25% (P < 0.05) by PKA, ATP, and Mg2+. This effect was abolished by immunodepletion of the cAMP regulatory protein (change = +5%, P = NS). These findings provide evidence that the regulation of renal BBM Na(+)-H+ exchange transport by PKA is affected by repletion and depletion of a specific protein. This suggests that PKA-mediated inhibition of the renal BBM Na(+)-H+ exchanger requires participation of a regulatory protein that is distinct from the transporter itself.
A realistic dynamic cardiac phantom for evaluating radionuclide ventriculography: description and initial studies with the left ventricular chamber. (1989)

A phantom was devised to validate scintigraphically determined left ventricular ejection fractions (LVEFs) and cardiac chamber volumes in the following simulated cardiac situations: normal contraction, moderately impaired left ventricular contraction, severely impaired left ventricular contraction, mitral regurgitation, and cardiomyopathy. The phantom, assembled from anatomically realistic cardiac chambers, simulated contraction and expansion using individual chamber pumps coordinated by a microcomputer. Scintigraphic studies were performed by sequential imaging of [99mTc]pertechnetate introduced into each chamber. The images were analyzed like conventional clinical studies, using both automatic and manual techniques. Scintigraphic techniques correlated with chamber volumes that were determined by weight to yield the following regression formulae: LVEF (by automatic method 1) = 1.08 x LVEF (by weight) -5.11; LVEF (by automatic method 2) = 1.00 x LVEF (by weight) -3.15; and LVEF (by manual method) = 1.04 x LVEF (by weight) -5.08 ml (Correlation coefficients greater than 0.98). The absolute left ventricular volumes (LVVs), determined by scintigraphy, correlated well with LVVs determined by weight. These correlations were performed with separations between the center of the left ventricle and the collimator varying from 5 cm to 9 cm. The regression formulae for 5, 7, and 9 cm distances were: LVV (by counts) = 0.99 x LVV (by weight) + 0.13, LVV (by counts) = 1.04 x LVV (by weight) + 9.08, LVV (by counts) = 0.88 x LVV (by weight) + 15.25, respectively. At 9 cm, slight volumetric underestimation occurred, as predicted from the work of Fearnow et al., possibly because of oversubtraction of background. Thus, this phantom provides a useful tool for validating scintigraphic cardiac blood-pool studies simulating a wide range of clinically relevant situations.
An Arbitrary Tree-Structured Replica Control Protocol (2008)

Traditional replication protocols that arrange logically the replicas into a tree structure have reasonable availability, low communication costs but induce high system load. We propose in this paper the arbitrary protocol: a tree-based replica control protocol that can be configured based on the frequencies of read and write operations in order to provide lower system load than existing tree replication protocols, yet with comparable cost and availability. Our protocol enables the shifting from one configuration into another by just modifying the structure of the tree. There is no need to implement a new protocol whenever the frequencies of read and write operations change. At the heart of our protocol lies the new idea of logical and physical levels in a tree. In short, read operations are carried out on any physical node of every physical level of the tree whereas the write operation is performed on all physical nodes of a single physical level of the tree. We discuss optimal configurations, proving in particular a new lower bound, of independent interest, for the case of a binary tree.
Hereditary Influence in Thoracic Aortic Aneurysm and Dissection (2016)

Thoracic aortic aneurysm is a potentially life-threatening condition in that it places patients at risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis of thoracic aortic aneurysm is quite limited. A genetic predisposition to thoracic aortic aneurysm has been established, and gene discovery in affected families has identified several major categories of gene alterations. The first involves mutations in genes encoding various components of the transforming growth factor beta (TGF-β) signaling cascade (FBN1, TGFBR1, TGFBR2, TGFB2, TGFB3, SMAD2, SMAD3 and SKI), and these conditions are known collectively as the TGF-β vasculopathies. The second set of genes encode components of the smooth muscle contractile apparatus (ACTA2, MYH11, MYLK, and PRKG1), a group called the smooth muscle contraction vasculopathies. Mechanistic hypotheses based on these discoveries have shaped rational therapies, some of which are under clinical evaluation. This review discusses published data on genes involved in thoracic aortic aneurysm and attempts to explain divergent hypotheses of aneurysm origin.
Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers (2011)

We investigated the behavior of the pH and thermo-responsive poly(2-(diethylamino)ethyl methacrylate-co-methacrylic acid)-b-(ethylene glycol methyl ether methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate-co-methacrylic acid) (P(DEAEMA-co-MAA)-b-PEGMA-b-P(DEAEMA-co-MAA)) triblock terpolymers in aqueous solution by means of static and dynamic light scattering, transmission electron microscopy and rheology. Association phenomena were observed at the isoelectric point region of the polyampholyte outer blocks leading to flower-like micelles and at higher polymer concentrations, to a three dimensional transient micellar network, exhibiting a compex thermo-response thanks to the thermo-sensitivity of the PEGMA middle block. Doxorubicin (DOX) drug was loaded in the terpolymer micelles and drug release studies were performed. Controlled drug delivery could be achieved by tuning pH. The terpolymer micelles exhibited satisfactory cytocompatibility towards human umbilical vein endothelial cells.
Quantum well carrier sweep out: relation to electroabsorption and exciton saturation (1991)

The authors studied the effects of changing the barrier design of GaAs-Al/sub x/Ga/sub 1-x/As quantum wells on the electroabsorption, exciton saturation, and carrier sweep-out times. Five samples with x values ranging from 0.2 to 0.4 and barrier thicknesses from 35 to 95 AA were studied. Within this range, the authors find that the electroabsorption is not very sensitive to the barrier thickness, but that the ionization field of the excitons approximately doubles for an increase of x from 0.2 to 0.4. The samples with high, thick barriers have lower internal quantum efficiencies than those with low, thin barriers. It was found that the exciton saturation intensity increases with increasing applied field, and decreasing barrier thickness or height. Time-resolved electroabsorption measurements confirm the variation in sweep-out rates between samples, and indicate that the escape mechanism at low field is probably a thermally-assisted tunneling process.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effects of hyaluronan on proteoglycan content of osteoarthritic chondrocytes in vitro (2002)

In osteoarthritic chondrocytes cultured phenotypically stable, HA could exhibit protective effects only in the presence of the degradative cytokine IL-1beta. Thus, the reported anti-inflammatory effects of HA to cartilage matrix seem to be more indirect by blocking degradative effects of cytokines to the matrix.
Land degradation control and its global environmental benefits (2005)

Abstract Acknowledged by world leaders as a global problem, land degradation has been taken seriously in three ways: its extent and the proportion of the global population affected; international environmental policy responses; and its inter‐relation with other global environmental issues such as biodiversity. Messages about land degradation have, however, suffered from abuses, which have rendered appropriate policy responses ineffective. For control to be effective, the paper argues that the synergies between land degradation and the two other main global environmental change components (biodiversity and climate change) should be more fully exploited. A focus on the interlinkages, of which there are six possible permutations, is fully supported by empirical findings that suggest that land degradation control would not only technically be better served by addressing aspects of biodiversity and climate change but also that international financing mechanisms and the major donors would find this more acceptable. The DPSIR (Driving Force, Pressure, State, Impacts, Response) conceptual framework model is used to illustrate how land degradation control could be more effective, tackling not only the drivers of change but also major developmental issues such as poverty and food insecurity. Copyright © 2005 John Wiley & Sons, Ltd.
Analysis of evaporation of cadmium sulfide for manufacture of solar cells (1982)

Abstract Vacuum sublimation of cadmium sulfide for manufacture of thin film solar cells was analyzed. The sublimation unit consisted of a two chamber cylindrical source bottle having a rate control orifice and exit nozzle. Coupled heat and mass balance equations were solved using appropriate rate equations for flow in the free molecular‐to‐viscous transition regime. The model equations predicted that heat transfer has a significant effect on sublimation rate. Experiments were carried out over a range of temperatures with several rate control orifices and exit nozzles. Quantitative agreement between measured rates and those calculated from the model equations was obtained.
Robotic manipulators with remotely-actuated joints: implementation using drive-shafts and u-joints (2006)

A popular configuration for the actuation of robotic manipulators with articulated joints is to have motors directly attached to the joints. This approach does not involve any transmission elements between the actuators and the joints and it is advantageous in many respects. However, in certain cases this configuration may not be appropriate and manipulators with remotely-actuated joints may be desirable. In this article different alternatives for the implementation of remote actuation would be discussed and a case study would be presented relevant to a robotic arm, which was designed to operate inside a closed cylindrical magnetic resonance imaging (MRI) scanner for the performance of image-guided interventions. The transfer of motion to the articulated joints of the arm was implemented using drive shafts and universal joints (u-joints). Experimental testing of the arm highlights issues relevant to remote actuation
Heterogeneous Graph Neural Networks for Extractive Document Summarization (2020)

As a crucial step in extractive document summarization, learning cross-sentence relations has been explored by a plethora of approaches. An intuitive way is to put them in the graph-based neural network, which has a more complex structure for capturing inter-sentence relationships. In this paper, we present a heterogeneous graph-based neural network for extractive summarization (HeterSumGraph), which contains semantic nodes of different granularity levels apart from sentences. These additional nodes act as the intermediary between sentences and enrich the cross-sentence relations. Besides, our graph structure is flexible in natural extension from a single-document setting to multi-document via introducing document nodes. To our knowledge, we are the first one to introduce different types of nodes into graph-based neural networks for extractive document summarization and perform a comprehensive qualitative analysis to investigate their benefits. The code will be released on Github