gebhart/patrepeval huggingface dataset:
Hydroboration. 56. Convenient and regiospecific route to functionalized organosilanes through the hydroboration of alkenylsilanes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroboration. 56. Convenient and regiospecific route to functionalized organosilanes through the hydroboration of alkenylsilanesJohn A. Soderquist and Herbert C. BrownCite this: J. Org. Chem. 1980, 45, 18, 3571–3578Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/jo01306a006https://doi.org/10.1021/jo01306a006research-articleACS PublicationsRequest reuse permissionsArticle Views1155Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Capabilities Approach to Successful Societies (2010)

What creates a successful society? There is no simple answer to this question because decisions about the criteria by which success should be measured inevitably depend on normative judgments that are contestable, and real-world conditions often entail concessions on some dimensions of success to secure improvements in others. For these reasons, even the most sophisticated e"orts to address this problem, such as Amartya Sen’s impressive theory of development as freedom, can be frustratingly indeterminate. As Michèle Lamont and I argue in Successful Societies: How Institutions and Culture A!ect Health (Cambridge University Press 2009), however, this question is too important to ignore. Even when the answers are necessarily incomplete, social scientists should be asking such questions. Although there is a natural preference for more tractable subjects, the watchword of social science should not be ‘convenience’. We need to advance our understanding not only of how societies work but of how they can work better.
Resistance of Greenhouse Whitefly (Homoptera: Aleyrodidae) to Insecticides in Selected Ohio Greenhouses (1983)

Journal Article Resistance of Greenhouse Whitefly (Homoptera: Aleyrodidae) to Insecticides in Selected Ohio Greenhouses Get access E. A. Elhag, E. A. Elhag Search for other works by this author on: Oxford Academic PubMed Google Scholar David J. Horn David J. Horn Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 76, Issue 4, 1 August 1983, Pages 945–948, https://doi.org/10.1093/jee/76.4.945 Published: 01 August 1983 Article history Received: 28 January 1983 Accepted: 18 April 1983 Published: 01 August 1983
A phase I trial of plinabulin in combination with nivolumab and ipilimumab in patients with relapsed small cell lung cancer (SCLC): Big Ten Cancer Research Consortium (BTCRC-LUN17-127) study. (2021)

8570 Background: Plinabulin (BPI-2358) is a vascular disrupting agent with immune-enhancing function by inducing dendritic cell maturation and decreasing regulatory T cells. Preclinical studies report that plinabulin potentiates the cytotoxicity of dual checkpoint inhibition (CPI) with nivolumab and ipilimumab. Plinabulin may also reduce immune-related AEs from CPI through its phosphodiesterase-4 (PDE4) inhibitory activity which is associated with anti-inflammatory effects. We report initial results from a Phase I study assessing plinabulin in combination with nivolumab and ipilimumab. Methods: In this dose-escalation phase I study, patients with extensive-stage SCLC who had progressed on or after prior platinum-based chemotherapy (±CPI) were enrolled using a 3+3 design. The primary objective was to determine dose-limiting toxicities (DLT’s) and recommended Phase 2 dose (RP2D). Patients received nivolumab (1 mg/kg), ipilimumab (3 mg/kg) and plinabulin (as per dose escalation schema) IV on day 1 of each 21 day cycles. After completion of 4 cycles, patients continued therapy with nivolumab (240 mg) and plinabulin every 2 weeks till progression or intolerable toxicity. Patients were evaluable for DLT if they received at least 2 cycles of therapy; DLT period was defined as the first 6 weeks from C1D1. Secondary endpoints were ORR, PFS and frequency of irAEs. Correlative analysis included inflammatory biomarkers: hsCRP, ESR, SAA and haptoglobin. Results: Between 9/2018 and 11/2020, 17 patients were enrolled (1 patient withdrew consent before treatment, 16 were evaluable for safety). Median age was 59 years (range 43 to 78); 9 patients were male and 10 had received prior CPI. Eight patients were treated at dose-level 1 of plinabulin (20 mg/m2) and 8 patients at 30 mg/m2 of plinabulin (level 2); dose-level 2 was determined to be RP2D. There were 2 DLTs; 1 at dose-level 1 (grade 3 altered mental status lasting < 24 hours) and 1 at dose-level 2 (grade 3 infusion reaction). The most common treatment-related AEs (all grades) were nausea (10; 63%), infusion reaction (8; 50%), vomiting (7; 44%), diarrhea (7; 44%) and fatigue (6, 32%). Seven patients (44%) had at least one grade 3 or higher treatment-related AE; there were no treatment-related deaths. Two patients (13%) had grade 3 or higher irAE requiring steroids (1 colitis, 1 transaminitis); both at dose-level 1. At data cutoff (12/30/20), there were 3 PRs in CPI naïve patients (3/6; 50%) and 2 PRs in evaluable CPI-resistant patients (2/7; 29%). In the two CPI-resistant patients with confirmed response, the tumor reduction was 68% and 52%. Conclusions: Plinabulin in combination with nivolumab and ipilimumab was safe and well tolerated. A phase 2 study in CPI-experienced patients with relapsed SCLC is planned to confirm the preliminary signals of clinical activity and reduced immune toxicity. Clinical trial information: NCT03575793.
Object detection based on RGC mask R‐CNN (2020)

Object detection is a crucial topic in computer vision. Mask Region‐Convolution Neural Network (R‐CNN) based methods, wherein a large intersection over union (IoU) threshold is chosen for high quality samples, have often been employed for object detection. However, the detection performance of such methods deteriorates when samples are reduced. To address this, the authors propose an improved Mask R‐CNN‐based method: the ResNet Group Cascade (RGC) Mask R‐CNN. First, they compared ResNet with different layers, finding that ResNeXt‐101‐64 × 4d is superior to other backbone networks. Secondly, during the training of the test model, the performance of Mask R‐CNN suffered from a small batch processing scale, resulting in inaccurately calculated mean and variance; thus, group normalisation was added to the backbone, feature pyramid network neck and bounding box head of the network. Finally, the higher the intersection of Mask R‐CNN than the threshold, the easier it is to obtain high‐quality samples. However, blindly selecting a high threshold leads to sample reduction and overfitting. Thus, a proposed cascade network configuration with three IoU thresholds was utilised in the process of model training. The model was trained and tested on the COCO and PASCAL VOC07 datasets. Their proposed algorithm demonstrated superior performance compared to that of the Mask R‐CNN.
Cataloging the World (2018)

The dream of capturing and organizing knowledge is as old as history. From the archives of ancient Sumeria and the Library of Alexandria to the Library of Congress and Wikipedia, humanity has wrestled with the problem of harnessing its intellectual output. The timeless quest for wisdom has been as much about information storage and retrieval as creative genius.
New Kids on the Blockchain: How Bitcoin's Technology Could Reinvent the Stock Market (2016)

Bitcoin is the first and most successful digital currency in the world. It polarizes the news almost daily, with either glowing reviews of the many benefits of an alternative and international currency, or doomsday predictions of anarchy, deflation, and another tulip bubble.\nThis article focuses on the truly innovative aspect of Bitcoin - and that which has gone mostly unnoticed since its inception - the technological platform used to transfer Bitcoin from one party to another. This technology is called the Blockchain. The Blockchain eschews a bank or other intermediary and allows parties to transfer funds directly to one another, using a peer-to-peer system. This disruptive technology has done for money transfers what email did for sending mail - by removing the need for a trusted third party just as email removed the need for using the post office to send mail.\nIf this technology can be used for peer-to-peer money transfers, why not extend the technology to accomplish other forms of transfers? Imagine selling a house or buying a car peer-to-peer. What about using the Blockchain technology to buy and sell stocks? Stocks exchanged completely peer-to-peer could resolve many of the issues facing the stock market today, including high frequency trading and short sales. This article develops a peer-to-peer stock market system, the legal implications of such a system, and how this system will fit in with current legislation and regulation.
Staufen1-mediated mRNA decay induces Requiem mRNA decay through binding of Staufen1 to the Requiem 3'UTR (2014)

Requiem (REQ/DPF2) was originally identified as an apoptosis-inducing protein in mouse myeloid cells and belongs to the novel Krüppel-type zinc finger d4-protein family of proteins, which includes neuro-d4 (DPF1) and cer-d4 (DPF3). Interestingly, when a portion of the REQ messenger ribonucleic acid (mRNA) 3' untranslated region (3'UTR), referred to as G8, was overexpressed in K562 cells, β-globin expression was induced, suggesting that the 3'UTR of REQ mRNA plays a physiological role. Here, we present evidence that the REQ mRNA 3'UTR, along with its trans-acting factor, Staufen1 (STAU1), is able to reduce the level of REQ mRNA via STAU1-mediated mRNA decay (SMD). By screening a complementary deoxyribonucleic acid (cDNA) expression library with an RNA-ligand binding assay, we identified STAU1 as an interactor of the REQ mRNA 3'UTR. Specifically, we provide evidence that STAU1 binds to putative 30-nucleotide stem-loop-structured RNA sequences within the G8 region, which we term the protein binding site core; this binding triggers the degradation of REQ mRNA and thus regulates translation. Furthermore, we demonstrate that siRNA-mediated silencing of either STAU1 or UPF1 increases the abundance of cellular REQ mRNA and, consequently, the REQ protein, indicating that REQ mRNA is a target of SMD.
Accurate quantification of brown adipose tissue mass by xenon-enhanced computed tomography (2017)

Detection and quantification of brown adipose tissue (BAT) mass remains a major challenge, as current tomographic imaging techniques are either nonspecific or lack the necessary resolution to quantify BAT mass, especially in obese phenotypes, in which this tissue may be present but inactive. Here, we report quantification of BAT mass by xenon-enhanced computed tomography. We show that, during stimulation of BAT thermogenesis, the lipophilic gas xenon preferentially accumulates in BAT, leading to a radiodensity enhancement comparable to that seen in the lungs. This enhancement is mediated by a selective reduction in BAT vascular resistance, which greatly increases vascular perfusion of BAT. This enhancement enables precise identification and quantification of BAT mass not only in lean, but also in obese, mouse phenotypes, in which this tissue is invisible to conventional tomographic imaging techniques. The method is developed and validated in rodents and then applied in macaques to assess its feasibility in larger species.
Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles (2019)

Superparamagnetic iron oxide nanoparticles are one of the most prominent agents used in theranostic applications, with MRI imaging the main application assessed. The biomolecular interface formed on the surface of a nanoparticle in a biological medium determines its behaviour in vitro and in vivo. In this study, we have compared the formation of the protein corona on highly monodisperse iron oxide nanoparticles with two different coatings, dimercaptosuccinic acid (DMSA), and after conjugation, with a bifunctional polyethylene glycol (PEG)-derived molecule (2000 Da) in the presence of Wistar rat plasma. The protein fingerprints around the nanoparticles were analysed in an extensive proteomic study. The results presented in this work indicate that the composition of the protein corona is very difficult to predict. Proteins from different functional categories—cell components, lipoproteins, complement, coagulation, immunoglobulins, enzymes and transport proteins—were identified in all samples with very small variability. Although both types of nanoparticles have similar amounts of bonded proteins, very slight differences in the composition of the corona might explain the variation observed in the uptake and biotransformation of these nanoparticles in Caco-2 and RAW 264.7 cells. Cytotoxicity was also studied using a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Controlling nanoparticles’ reactivity to the biological environment by deciding on its surface functionalization may suggest new routes in the control of the biodistribution, biodegradation and clearance of multifunctional nanomedicines.
Advanced design of phased-array beam-forming networks (1996)

Recent, very general and fundamental results in the theory of electrically large microwave networks lead to new, advanced designs of high-efficiency beam-forming networks, for high-directivity electronically-steered phased arrays. On the basis of the rigorous new results, the beam-forming networks of electronically-steered phased arrays can be simultaneously impedance matched to any given set of radiating elements on one side, and to any given set of mutually-coherent, phase- and amplitude-controlled microwave sources on the other. Further, the impedance match attained in transmission also holds in reception, as long as the set of mutually-coherent receivers used has the same internal impedances as the set of sources used. The impedance match attained accounts simultaneously for both the electromagnetic proximity coupling between all the radiating array elements, and for any given internal cross-coupling of the set of sources, in transmission, or of the set of receivers, in reception. The resulting impedance match is totally independent from the amplitude and phase settings of the sources, in transmission, and from the direction of the incoming beam, in reception, completely suppressing the notorious array-blindness effect for all beam directions. Further, beam-forming networks can also be designed with prescribed transmission responses-besides a prescribed impedance match-in both the transmission and reception modes, and with a number of beam-steering control components that is much smaller than the number of array elements.
Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended‐release formulation (2008)

A woman with acute poisoning from extended-release paracetamol presented at 14.5 hours post-ingestion. The paracetamol's absorption phase and elimination half-life appeared prolonged, with peak blood concentration occurring at 20 hours post-ingestion, requiring an extended course of intravenous N-acetylcysteine. Current treatment recommendations, based on experience with a different formulation in the United States, may not be appropriate for the Australian formulation.
New Approaches for Integration: Integration of Haptic Garments, Big Data Analytics, and Serious Games for Extreme Environments (2017)

Haptic garments present new opportunities to increase realism in gaming. As Real As It Gets (ARAIG) is a new form of haptic garment that uses muscle stimulation, vibration, and 7.1 surround sound to provide a new level of realism in gaming. The integration of new haptic garments like ARAIG with big data analytics and serious games presents new opportunities for more realistic virtual training that has application in many domains. In particular, there is great potential to support repeatable virtual training for extreme environments. In 2016, the IEEE Life Sciences Technical Community worked across the IEEE Societies to demonstrate this interdisciplinary nature, with a focus on solving life science problems in extreme environments. This article is based on our keynote address at the International Conference on Consumer Electronics (ICCE)-Berlin in 2016. It provides an example of this interdisciplinary case study research in action.
Abstractions for Model-Based Testing (2005)

The idea of model-based testing is to compare the I/O behavior of an explicit behavior model with that of a system under test. This requires the model to be valid. If the model is a simplification of the SUT, then it is easier to check the model and use it for subsequent test case generation than to directly check the SUT. In this case, the different levels of abstraction must be bridged. Not surprisingly, experience shows that choosing the right level of abstraction is crucial to the success of model-based testing. We argue that models for specification purposes, models for test generation, and models for full code generation are likely to be different. The paper classifies and discusses different abstractions. It is intended as a step towards guidelines for those who build behavior models to the end of testing.
MEMBERSHIP DETERMINATION IN GLOBULAR CLUSTERS WITHGAIA DR2 ASTROMETRY (2020)

In this work we present a method -still under development- to identify possible members of globular clustersusing data from Gaia DR2. The method is based on a clustering algorithm applied on a 4D space that isdetermined basically by the positions on the sky and the proper motions. In order to confirm that the clustersautomatically detected by the method correspond to actual globular clusters, their colour-magnitude diagramsare analysed. We show the results for some clusters and compare them with other authors.
Dose Measurement on Both Patients and Operators during Neurointerventional Procedures Using Photoluminescence Glass Dosimeters (2008)

It was shown that the regional ESD could be measured by applying the PLD. This method should contribute to reducing the dose accumulation in patients as well as in operators.
Anticipative grid design in point-mass approach to nonlinear state estimation (2002)

Numerical solution of the Bayesian recursive relations by the point-mass approach is treated. The stress is laid on the grid design as the main user design problem in this approach. An anticipative approach for finding a minimum sufficient number of grid points is developed, yielding a new adaptive algorithm reducing the computational operations without a loss of estimation accuracy. A numerical example is presented to compare the new algorithm with the standard point-mass technique and with a sequential importance sampling nonlinear filtering algorithm.
New Downhole Electromechanical Service Tool Advancements Provide Increased Integrity in HP/HT Environments (2006)

Abstract During the 1990’s, a battery-powered electro-mechanical downhole service tool used to set/retrieve various pressure containment devices in the wellbore was introduced to the industry. These electro-mechanical actuators are capable of generating high but controllable axial forces at the point of application without relying on surface mechanical manipulations or explosive devices. This capability eliminates most of the logistical special safety considerations inherent with explosive actuators. Since the self-powered tool is independent of the surface machinery, another advantage is that it is possible to reduce the surface footprint for more efficient logistical management. The electro-mechanical service tools are compatible with conventional slickline intervention methods and provide a practical alternative for explosive and hydrostatic setting tools. (See Fig. 1). This tool has also added significant cased-hole functionality to slickline intervention methods. While the first generation of the electro-mechanical service tools met the majority of conditions needed in the 1990’s, their functionality could not meet some of the operating requirements needed by the deeper, higher pressure fields being produced today. This paper will describe a new tool system that provides the advantages of the standard downhole power unit (DPU®) system but overcomes the temperature limitations imposed by the more demanding downhole environments in today’s oilfield. The control logic, power management, and power delivery methods used to develop a functional and reliable electro-mechanical actuator for high-temperature/high pressure applications will be discussed. Also outlined is the environmental test program representing real world conditions that was used to validate its reliability. Finally, case histories will be presented.
Bukittinggi City Space Transformation Based on Tourism Development (2022)

Bukittinggi City is a city in West Sumatra Province that is one of the popular tourist destinations for the public and tourists. The existence of tourist objects around the city center greatly affects the structure of urban space, in the use of space itself, it is very visible from the distribution of tourist facilities locations that spread around tourist objects that can attract hospitality and trade activities that spread to the downtown area in Bukittinggi. This study aims to determine how the spatial transformation of Bukittinggi City is based on tourism development from 1984 to 2021 and the factors that influence the development of the space. The method used in this research is qualitative. This study found that the City of Bukittinggi when viewed from the area of â€‹â€‹development of the City of Bukittinggi reflects a concentric pattern, this can be seen from the location of the city of Ngarai Sianok which limits the development of the city to the west and north. Based on the performance agreement letter from the Public Works and Spatial Planning Office of Bukittinggi City in 2020, the percentage of suitability for spatial planning and utilization is 37.50%. The building mass in a developing tourist attraction has a heterogeneous textured area texture, where the shape of the mass and space configuration have different sizes, shapes, and densities. The high density of building mass only occurs in the core area of â€‹â€‹the city with a percentage above 80%. The Bukittinggi City Regional Spatial Plan article 28 paragraph 2 explains that there are 5 types of road networks, namely primary arterial roads, secondary arteries, secondary collectors, local roads, and freeways. The road network in Bukittinggi City is growing rapidly towards the city center and in several residential areas. The distribution of tourist facilities is generally located in the city center and a small part is spread along Jalan Soekarno Hatta and Jalan Sudirman. The distribution of tourist objects has formed a concentric space in the city's core area with local and regional service scales.