gebhart/patrepeval huggingface dataset:
Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis. (1995)

We have previously reported that rho genes, members of the ras superfamily, are tumorigenic when overexpressed in NIH 3T3 cells. As other known oncogenes, they also induce apoptosis after serum deprivation but not in the presence of growth factors. In the present study, we provide evidence that overexpression of the Aplysia Rho protein in NIH 3T3 cells induces the generation of phosphatidylcholine (PC)-derived second messengers as a result of activation of a PC-specific phospholipase D (PC-PLD) as previously reported for ras-transformed cells. In contrast, removal of serum in the Rho transfectants, but not in normal NIH 3T3 cells or cells transformed by the ras oncogene, induced the production of ceramides as a result of activation of an sphingomyelinase (SMase). Furthermore, the rho-expressing cells underwent apoptosis in the presence of serum when exogenous ceramides were added, and this process was accelerated if cells were treated with exogenous SMase. Thus, Rho proteins act as an initiation signal that is necessary but not sufficient for the induction of apoptosis in NIH 3T3 cells. We propose here that induction of apoptosis in NIH 3T3 cells requires two complementary signals: an initiation signal generated even in the presence of serum which 'primes' the cells, making them sensitive to a progression signal, triggered by serum removal, which we have identified as generation of ceramides.
A Light-Emitting Field-Effect Transistor (2000)

We report here on the structure and operating characteristics of an ambipolar light-emitting field-effect transistor based on single crystals of the organic semiconductor alpha-sexithiophene. Electrons and holes are injected from the source and drain electrodes, respectively. Their concentrations are controlled by the applied gate and drain-source voltages. Excitons are generated, leading to radiative recombination. Moreover, above a remarkably low threshold current, coherent light is emitted through amplified spontaneous emission. Hence, this three-terminal device is the basis of a very promising architecture for electrically driven laser action in organic semiconductors.
Java RMI versus .NET Remoting Architectural Comparison and Performance Evaluation (2008)

The implementation of distributed applications can be based on a multiplicity of technologies, e.g. plain sockets, Remote Procedure Call (RPC), Remote Method Invocation (RMI), Java Message Service (JMS), .NET Remoting, or Web Services. These technologies differ widely in complexity, interoperability, standardization, and ease of use. To achieve the highest efficiency, the use of plain sockets is advisable, whereas highest interoperability and standardization argue for Web Services. Real world applications requirements are a trade-off between efficiency, development costs, usability, reliability, interoperability, and so on. For example, a multimedia streaming application requires high performance to avoid delays, whereas Internet trading platforms depend on high interoperability, reliability and availability. Since Java RMI and .NET Remoting support fast development of highly efficient applications, many developers choose one of these technologies to realize their applications. Besides differences in design, the two technologies offer diverse performance characteristics. This paper has two main contributions: (1) a comparison of the design and architecture of Java RMI and .NET Remoting is presented, (2) an experimental performance analysis with respect to various aspects of both technologies is conducted.
X-ray computed tomography (2021)

X-ray computed tomography (CT) can reveal the internal details of objects in three dimensions non-destructively. In this Primer, we outline the basic principles of CT and describe the ways in which a CT scan can be acquired using X-ray tubes and synchrotron sources, including the different possible contrast modes that can be exploited. We explain the process of computationally reconstructing three-dimensional (3D) images from 2D radiographs and how to segment the 3D images for subsequent visualization and quantification. Whereas CT is widely used in medical and heavy industrial contexts at relatively low resolutions, here we focus on the application of higher resolution X-ray CT across science and engineering. We consider the application of X-ray CT to study subjects across the materials, metrology and manufacturing, engineering, food, biological, geological and palaeontological sciences. We examine how CT can be used to follow the structural evolution of materials in three dimensions in real time or in a time-lapse manner, for example to follow materials manufacturing or the in-service behaviour and degradation of manufactured components. Finally, we consider the potential for radiation damage and common sources of imaging artefacts, discuss reproducibility issues and consider future advances and opportunities. This Primer on X-ray computed tomography explores the different experimental configurations for three-dimensional data acquisition as well as the fundamentals of three-dimensional data reconstruction, segmentation and analysis with examples across the physical and life sciences.
Calibration of Incoherent Optical Fiber Bundles for Image Transmission. Fibers Detection Process (2007)

Image transmission by incoherent optical fibers bundles requires a previous calibration to obtain the fibers spatial in-out correspondence in order to reconstruct at the output side an image presented on the input of the system. This information is recorded in a look-up table for later reordering of the fibers positions and reconstructs the original image. This paper shows how to minimize calibration time and improve the quality of the recovered image, by using a fibers detection process reducing the number of points to take into account in the calibration process. There is, also, an improvement in the quality of the recovered image compared with others techniques. In this paper two detection methods of circular patterns have been applied to a fiber bundle image captured by a CMOS sensor. The former utilizes the algorithm of circular Hough transform based on the gradient field of the image. A second one is introduced as a new hybrid algorithm that mixes some morphological transformations and distance transform. The results demonstrate that this technique offers a remarkable reduction of processing time and good detection.
Metal-atom resonance-line lasers (1980)

UV photodissociation of alkali and group IIIa metal halides provides a simple, practical means of producing metal-atom resonance-line lasers. These lasers are useful for applications in remote sensing of the same metal atoms. A study of the laser physics of these devices provides basic physical information on the photodissociation of metal halides.
The national cancer data base report on prostate cancer (1994)

Background. Previous Commission on Cancer studies on prostate cancer have examined time trends in disease stage, treatment patterns, and survival. The most current National Cancer Data Base data for prostate cancer are reviewed in this report. Methods. Two Calls for Data have yielded a total of 85,813 prostate cancer reports from hospital registries across the country. Results. The proportion of early stage, curable prostate cancers diagnosed in the United States has increased. In 1990, African-American patients were more likely to be diagnosed with metastatic prostate cancer than were non-Hispanic whites. The proportion of patients treated by prostatectomy increased between 1974 and 1990. Consistent with the pattern of more advanced disease at diagnosis, African-American patients were less likely to have received prostatectomy or radiation treatment and more likely to have received only hormonal treatment. Prostate cancer survival was associated strongly with disease stage. African-American men had a lower 5-year survival than did non-Hispanic white men. Conclusions. This information provides national points of reference against which individual hospital performance can be compared and should be particularly helpful to cancer committees, tumor boards, and cancer registrars for the monitoring and evaluation of prostate cancer management in hospital cancer programs. Not all segments of the population-at-risk are benefiting from earlier detection of prostate cancer. Improvements in early detection have important consequences for treatment patterns, allowing the increased use of curative surgical or radiotherapeutic treatment.
Demo abstract: An intent solver for enabling intent-based SDN (2017)

In recent years, software-defined networking (SDN) has been adopted in practice, such as the fast-growing market of software-defined wide area networks (SD-WAN). Intent, an emerging concept for SDN, aims to provide a simple interface for operators to manage the network. Under the framework of intent, an application submits a request by specifying the objective only, and the SDN controller decides how to reconfigure the network by considering the objectives of multiple intents with potential conflicts. For instance, in SD-WAN, when multiple applications or flows are competing for limited MPLS resource, we need to decide how and when to redirect some of them to Internet broadband connections. To this end, an intent solver is needed to analyze the received intents, making optimized solutions to operate the network. In this demo, we present the prototype of an intent solver focusing on intents related to flow routing. The demo takes intents both from applications for establishing/adjusting connections and from the network operator for load balancing, and generates optimized routing/rerouting solutions in real time.
An 85-MHz fourth-order programmable IIR digital filter chip (1992)

The authors describe the design and VLSI implementation of a single-chip 85-MHz fourth-order infinite impulse response (IIR) digital filter chip fabricated in 0.9- mu m CMOS technology. The coefficient and input data word lengths of the filter are 10 b each, and the output data word length is 15 b. The coefficients are fully programmable. The chip can be programmed to implement any IIR filter from first to fourth order or an FIR filter up to 16th order at sample rates up to 85 MHz. A total of seventeen 10*10 multiply-add modules are used in this chip. The chip contains 80000 devices in an active area of 14 mm/sup 2/. It dissipates 2.2 W at 85-MHz clock rate and performs over 1.5*10/sup 9/ multiply-add operations per second. The underlying filtering algorithm, chip architecture, circuit and layout design, speed issues, and test results are described. The results of an E-beam probing experiment on packaged chips at 100-MHz clock rates are also presented and discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pharmacokinetics of Novel Hexapeptides with Neurotensin Activity in Rats. (1993)

A high-performance liquid chromatographic method to determine (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu (NT-2) with neurotensin (NT) activity in rat plasma was developed and a pharmacokinetic study was performed in rats. Quantitative analysis with high reproducibility was achieved for NT-2 over the concentration range of 1.14-500 ng/ml. (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu-OEt (NT-1) was rapidly hydrolyzed to NT-2 in rat plasma at 37 degrees C. This degradation of NT-1 was observed as a pseudo first-order reaction, and the pseudo first-order rate constant was calculated to be 7.26 min-1 (t1/2 = 0.095 min). The pharmacokinetic profiles of NT-2 after intravenous administration of NT-1 at doses of 0.1 and 0.3 mg/kg were compatible with that of NT-2 after intravenous administration of NT-2 at 0.5 mg/kg. Range of the half-life of the terminal phase (t1/2 beta) of NT-2 was 0.36-0.53 h. The absolute bioavailabilities after oral administrations of NT-1 and NT-2 at a dose of 20 mg/kg were 0.61 +/- 0.17 (mean +/- S.E.) and 0.19 +/- 0.08%, respectively. It was found that NT-1 was more suitable for oral administration than NT-2.
Highly Convergent Route to Dynemicins of Wide Structural Variability. Enantioselective Synthesis of Quinone Imine Precursors to Natural and Nonnatural Dynemicins (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Convergent Route to Dynemicins of Wide Structural Variability. Enantioselective Synthesis of Quinone Imine Precursors to Natural and Nonnatural DynemicinsAndrew G. Myers, Mark E. Fraley, and Norma J. TomCite this: J. Am. Chem. Soc. 1994, 116, 25, 11556–11557Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ja00104a041https://doi.org/10.1021/ja00104a041research-articleACS PublicationsRequest reuse permissionsArticle Views1007Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Time-Sharing Multithreading on Stream-Based Lossless Data Compression (2017)

To address the performance saturation in communication data path at migrating BigData, the lossless data compression technique is a solution to enhance the bandwidth of the path. However, the recent data compression mechanism needs to treat data streams such as sensor data with very low latency to avoid overhead in the path. This paper focuses on a new loss less data compression mechanism called LCA-DLT that implements a hardware-based fast stream lossless data compression using dictionary-based symbol lookup mechanism. When applying it to a very fast path, the hardware latency increases largely and the clock speed degrades because the dictionary lookup operation becomes bottleneck of the longest delay path in the hardware. This paper proposes a performance improvement technique applying multithreading technique in the dictionary lookup operation. The technique enables a single module of the LCA-DLT to accept multiple data streams by dividing the compression timing in babble stage of the compression/decompression pipeline. According to performance evaluation by a hardware implementation with two threads, although the data compression bandwidth logically becomes half of the original single thread LCA-DLT, the time-sharing multithreading technique reduces required hardware resources and improves the clock frequency.
The Market as a Distributive and Allocative System: Its Legal, Ethical, and Analytical Evolution (1994)

Research Article| January 01 1994 The Market as a Distributive and Allocative System: Its Legal, Ethical, and Analytical Evolution S. Todd Lowry S. Todd Lowry Search for other works by this author on: This Site Google History of Political Economy (1994) 26 (suppl_1): 23–46. https://doi.org/10.1215/00182702-1994-suppl_1003 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation S. Todd Lowry; The Market as a Distributive and Allocative System: Its Legal, Ethical, and Analytical Evolution. History of Political Economy 1 January 1994; 26 (suppl_1): 23–46. doi: https://doi.org/10.1215/00182702-1994-suppl_1003 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsHistory of Political Economy Search Advanced Search You do not currently have access to this content.
Biomechanical grippers: important elements of biomechanical robots (1997)

Presents both description and overview of the emerging field of biomechanical grippers and shows the prototype of biomechanical gripper called the Presov biomechanical robot gripper. Biomechanical robots and biomechanical grippers belong under biorobotics and bioengineering systems. Basic components of biorobotics include biomechanisms, biocontrol, biointelligence and biosensors. The Presov Biomechanical Robot Gripper is an electrically‐driven, multi‐fingered dextrous gripper, which has many features that conventional industrial robot grippers do not have. This gripper has been developed in the Department of Industrial Robotics of the Technical University in Presov, Slovak Republic.
Inhibitory Effect of a Potent and Selective Cytosolic Phospholipase A<sub>2</sub>α Inhibitor RSC-3388 on Skin Inflammation in Mice (2008)

Cytosolic phospholipase A2alpha (cPLA2alpha) preferentially hydrolyzes membrane phospholipids containing arachidonic acid, resulting in the biosynthesis of eicosanoids such as prostaglandins and leukotrienes. To examine the contribution of cPLA2alpha to skin inflammation, we evaluated the effect of (E)-N-[(2S,4R)-4-[N-(biphenyl-2-ylmethyl)-N-2-methylpropylamino]-1-[2-(2,4-difluorobenzoyl)benzoyl]pyrrolidin- 2-yl]methyl-3-[4-(2,4-dioxothiazolidin-5-ylidenemethyl) phenyl]acrylamide (RSC-3388), a potent and selective cPLA2alpha inhibitor, on 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced ear inflammation and mite antigen-induced dermatitis in mice. Topical application of RSC-3388 showed a significant inhibitory activity against TNCB-induced ear swelling and eicosanoid production in mice. Comprehensive expression analysis using Gene-Chip technology and subsequent experiments concerning mRNA and protein expression demonstrated that RSC-3388 clearly reduced the levels of interleukin-1beta, macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta in a TNCB-induced mouse model. In addition, RSC-3388 ointment significantly alleviated atopic dermatitis-like skin lesions induced by repeated application of mite antigen. Furthermore, increased expression of cPLA(2)alpha, assessed by anti-phospho-cPLA2alpha antibody, was observed in the skin lesions of mite-antigen-induced dermatitis. These results indicate that cPLA2alpha is involved in the development of skin inflammation in mice, and RSC-3388 is expected to be useful for the treatment of inflammatory skin disorders such as atopic dermatitis.
Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer. (2005)

The genotype of certain metabolizing enzymes affects the risk for colorectal cancer. This effect is particularly important when certain allelic combinations are studied. In the near future, individual level risk assessment may be reached by further increasing the number of studied polymorphisms, combining them with traditional epidemiological risk factors.
La música como elemento constituyente de estructura dramática en las Novelas ejemplares (2013)

Este trabajo analiza los elementos musicales presentes en las Novelas ejemplares. Proponemos que, al menos en Rinconete y Cortadillo, La ilustre fregona, El celoso extremeño y La fuerza de la sangre, estos elementos crean una estructura dramática en las Novelas. Esta hipótesis concuerda con el juicio de Avellaneda sobre las Ejemplares, quien llamó a las novelas cortas de Cervantes «comedias en prosa».
Software Reuse and Reusability Metrics and Models (1996)

: As organizations implement systematic software reuse programs to improve productivity and quality, they must be able to measure their progress and identify the most effective reuse strategies. This is done with reuse metrics and models. In this paper, we survey metrics and models of software reuse and reusability, and provide a classification structure that will help users select them. Six types of metrics and models are reviewed: cost-benefit models, maturity assessment models, amount of reuse metrics, failure modes models, reusability assessment models, and reuse library metrics. Introduction Software reuse, the use of existing software artifacts or knowledge to create new software, is a key method for significantly improving software quality and productivity. Reusability is the degree to which a thing can be reused. To achieve significant payoffs a reuse program must be systematic [Frakes and Isoda 94]. Organizations implementing systematic software reuse programs must be able to ...
Enhanced Gradient and Adaptive Learning Rate for Training Restricted Boltzmann Machines (2011)

Boltzmann machines are often used as building blocks in greedy learning of deep networks. However, training even a simplified model, known as restricted Boltzmann machine (RBM), can be extremely laborious: Traditional learning algorithms often converge only with the right choice of the learning rate scheduling and the scale of the initial weights. They are also sensitive to specific data representation: An equivalent RBM can be obtained by flipping some bits and changing the weights and biases accordingly, but traditional learning rules are not invariant to such transformations. Without careful tuning of these training settings, traditional algorithms can easily get stuck at plateaus or even diverge. In this work, we present an enhanced gradient which is derived such that it is invariant to bitflipping transformations. We also propose a way to automatically adjust the learning rate by maximizing a local likelihood estimate. Our experiments confirm that the proposed improvements yield more stable training of RBMs. 1.
Inhibition of fibroblast-like cell proliferation by interleukin-1 blockers, CK-119 and CK-122. (1998)

CK-119 and CK-122 are potent IL-1 blockers to inhibit cell growth of fibroblast-like corneal and conjunctival cells mainly through the inhibition of DNA and RNA syntheses but not protein synthesis.
Lp(a) Lipoprotein and Plasminogen Activity in Patients with Different Etiology of Ischemic Stroke (2006)

Our results support the hypothesis that elevated Lp(a) is a risk factor for ischemic stroke and especially for strokes caused by LAA. Low plasminogen activity may play a role in the pathogenesis of cerebrovascular disease, especially for the development of cardioembolic stroke.
Role of IL-15 in HIV-1-associated hypergammaglobulinaemia (1997)

IL-15 is a novel cytokine, produced by monocytes/macrophages, with biological activities similar to IL-2 but with no significant sequence homology. IL-15 also stimulates human B cells to proliferation and immunoglobulin secretion. We measured serum levels of IL-15 in 84 HIV-1-infected individuals at different stages of disease in reference to 41 healthy blood donors. Our results show a marked elevation of IL-15 serum levels during HIV-1 infection. Moreover, we found that this increase correlated with serum levels of IgG (r = 0.376, P < 0.0001), and partly with serum IgM (r = 0.265, P = 0.015). A significant increase of IL-15 production by cultured peripheral blood mononuclear cells (PBMC) and purified monocytes in the presence of HIV-1 virus suggests that monocytes/macrophages may be a source of higher IL-15 serum levels in HIV-1-infected individuals. These findings indicate a participation of IL-15 in the hypergammaglobulinaemia frequently associated with HIV-1 infection.