gebhart/patrepeval huggingface dataset:
Exploratory Study on the RNA‐Binding Structural Motifs by Library Screening Targeting pre‐miRNA‐29 a (2015)

The metabolic stream of microRNA (miRNA) production, the so-called maturation process of miRNAs, became one of important metabolic paths for drug-targeting to modulate the expression of genes related to a number of diseases. We carried out discovery studies on small molecules binding to the precursor of miR-29a (pre-miR-29a) from a chemical library containing 41,119 compounds (AQ library) by the fluorescent indicator displacement (FID) assay using the xanthone derivative X2SdiMe as a fluorescent indicator. The FID assay provided 1075 compounds, which showed an increase of fluorescence. These compounds were subsequently submitted to a binding analysis in a surface plasmon resonance (SPR) assay on a pre-miR-29a immobilized surface. 21 hit compounds were identified with a good reproducibility in the binding. These compounds have not been reported to bind to RNA until now and can be classified into two groups on the basis of the kinetics in the binding. To gain more information on the motif structures that could be necessary for the binding to pre-miR-29a, 19 substructures were selected from the hit compounds. The substructure library (SS library) which consisted of 362 compounds was prepared from the AQ library. An SPR assay of the SS library on pre-miR-29a-immobilized surface suggested that five substructures could potentially be important structural motifs to bind to pre-miR-29a. These studies demonstrate that the combination of FID-based screening of chemical library and subsequent SPR assay would be one way for obtaining practical solutions for the discovery of molecules which bind to the target pre-miRNAs.
PHEVs centralized/decentralized charging control mechanisms: Requirements and impacts (2013)

This paper investigates the main features of the PHEV centralized and decentralized charging control mechanisms, their requirements and also impacts on distribution system performance. A home-based charging control scenario as well as a coordinated charging control algorithm for the charging management of PHEVs is devised in this paper. Both the owner preferences and system operator concerns are taken into consideration in an optimization-based framework. The total network losses and charging costs are set as the constraints to the proposed optimization approach. Various aspects of the two mechanisms are discussed and comprehensively compared by their application on the IEEE 34-bus test system. The obtained results and discussions offered demonstrate the efficiency and applicability of the proposed approach in real world.
Multichannel signal processing for multiple-head digital magnetic recording (1994)

This paper analyzes the performance of a multiple-head, digital, magnetic recording system using multichannel signal processing theory. A multi-input, multi-output (MIMO) channel that models the multiple-head recording process provides the basis for this analysis. This model characterizes the write process, the read process and both electronics and media noise. In particular, the model accounts for side fringing between a read head and adjacent tracks; side fringing is a major cause of intertrack interference that is often neglected during signal processing analysis. Optimal decision feedback and partial response equalizers for the MIMO channel are derived using a minimum mean-squared error criterion. Numerical evaluations show that a magnetic recording system comprising a multiple-head array and equalizer combats intertrack interference much better than does the corresponding single-head system. As a result, the multiple-head system achieves a gain of up to a factor of 3.5 in radial density over the single-head system for a fixed value of maximum head misalignment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Versatile multistandard digital TV encoder based on programmable hardware (CPLD) (2002)

After giving a description of the three underlying standards of the digital video broadcasting system (DVB-S: satellite, DVB-C: cable and DVB-T: terrestrial), this paper discusses the synergy effects, which can be used to design a versatile multistandard digital television encoder with minimum hardware requirements. The paper shows the implementation possibilities of the signal-processing algorithms in Complex Programmable Logic Devices (CPLDs) for the example of a highly integrated digital TV encoder, which has been realized at the Chair of Communications Technology for measurement purposes.
Gender Balance Analysis of the Metropolitan Achievement Tests, 1978 Edition (1979)

Recent years have brought increased attention to gender balance in evaluation devices. Research indicates that current educational materials present males significantly more often than females, and both sexes almost exclusively in stereotypic roles. In revising the Metropolitan Achievement Tests, the publisher attempted to balance the presentation of sexes and to portray both sexes in less stereotypic roles. This study determines whether the revision conformed to these guidelines. Results indicate the present test content is significantly better balanced and less stereotypic than previous editions. Breakdowns of test content and various thematic categories are presented; data are compared across content areas and test levels.
Wafer-level packaging of three-dimensional MOEMS device with lens diaphragm (2007)

This paper presents wafer level packaging of a miniature MOEMS monochromator for biomedical spectroscopy. Optical microlens and piezoelectrically-actuated diffraction grating are fabricated, and packaged at a wafer level into a complete, integrated monochromator with a fiber input. The packaged monochromator is an optical and mechanical system derived from a macroscale Czerny Turner monochromator. It integrates an angled mirror for folding and directing the input light path. A lithographically-defined reflective diffraction grating accepts and spectrally separates the input light from a fiber that is inserted into the built-in groove. The diffracted light is then collected through a diaphragmsuspended microlens and spatially separated on its path towards the output of the system. The packaging, done via encapsulated silicon cavities, provides batch processing and finishing of the complete device. The MLD is characterized with a Gaussian beam propagation model and the SSC packaged device is measured by its resolution and stray light through profiling with a CCD array.
Non-viral delivery of ribozymes for cancer gene therapy (2004)

Ribozymes are RNA molecules with the capacity to effect sequence-specific cleavage of other transcripts. Since their initial discovery, there has been considerable interest in the development of ribozymes and other RNA therapeutics for gene therapy, particularly in the realm of cancer. However, as with other gene therapy applications, the delivery of ribozyme-based therapeutics to the target tissues of interest has represented a significant obstacle to the maturation of this technology to the clinical arena. This review will discuss the progress made so far in the use of non-viral methods for the systemic delivery of ribozymes for cancer gene therapy.
Speaker Verification with Combined Threshold, Identification Front-End, and UBM (2006)

This paper presents a novel approach to improve accuracy performance of a speaker verification system through combination or cascading three different verification methods using an identification "front-end", a universal background model, and an individual matching score threshold. The performance of a speaker verification system can be determined in terms of false rejection rate and false acceptance rate using a standard benchmark speech corpus, which represents fixed common populations in testing voice and claimed identities. By further assuming uniform distributions, it can show analytically that the false acceptance rate of a standalone system either using the threshold or the universal background model can be significantly reduced when combined with the identification ''front-end''. Experiments have provided clear evidence, and even more gains to combine all three methods together. The results show 60% reduction in the false acceptance rate for combining with the identification "front-end" alone, and 80% reduction for combining all three methods without adding penalty in the false rejection rate.
Mapping of T-cell epitopes of flagellar antigen d of Salmonella muenchen (1993)

Regions of the antigen d flagellin of Salmonella muenchen capable of causing the proliferation of repolymerized d flagellin-primed T cells were delineated by using dodecameric peptides. Three areas causing substantial DNA replication were identified, together with five areas eliciting less response. On the basis of known salmonella flagellin structure, the major areas were located in highly conserved regions of the molecule.
Polarization field effects at liquid-crystal-droplet–polymer interfaces (2006)

The influence of confinement (droplet size) and liquid crystal orientational order (smectic-A and nematic) on the interfacial polarization field effects [Maxwell-Wagner-Sillars (MWS) effect] existing in liquid-crystal-droplets-polymer systems is investigated by broadband dielectric spectroscopy and a forward transmittance measurement technique. A relaxation process observed in the low frequency domain of the dielectric spectrum has been associated with a MWS effect for both micron-size and submicron-size droplets. Using electro-optical measurements and numerical simulations of the field inside droplets, it is shown that a depolarization field takes place in the same frequency range as that determined by dielectric spectroscopy. Differential scanning calorimetry measurements allowed to estimate the phase-separated liquid crystal [4,4'-octylcyanobiphenyl (8CB)] fraction, which was found in the range of 55% for both micron-size and submicron-size droplets. X-ray diffraction experiments showed that smectic 8CB confined to micron-size cavities adopt bulklike properties, i.e., a partial bilayer structure, whereas in submicron-size droplets the layer spacing of the smectic phase is increased due to the strong bending deformations induced by the high curvature of the cavity walls.
Chopper-Stabilized Bidirectional Current Acquisition Circuits for Electrochemical Amperometric Biosensors (2013)

Two low-noise bidirectional current acquisition circuits for interfacing with electrochemical amperometric biosensor arrays are presented. The first design is a switched-capacitor transimpedance amplifier (TIA). The second design is a current conveyer (CC) with regulated-cascode current mirrors. Both circuits employ chopper stabilization to reduce flicker noise. The TIA and the CC were prototyped in 0.13 μm CMOS and consume 3 μW and 4 μW from a 1.2 V supply, respectively. The electrical and electrochemical recording properties of both circuits have been characterized. The current conveyer exhibits superior performance in low-concentration electrochemical catalytic reporter sensing, as less switching noise is injected into the biosensor.
Journal of Chinese Integrative Medicine (2012)

There is airway inflammation with eosinophilic infiltration in asthmatic mice, accompanied with suppressed apoptosis and delayed apoptosis. Kechuanluo can induce and accelerate EOS apoptosis in early inflammation by inhibiting eosinophilic inflammation, improving Fas expression in EOSs and FasL expression in the lung tissues, and reducing Bcl-XL expression in EOSs.
Noise robust hands-free speech recognition using microphone array and Kalman filter as front-end system of conversational TV (2004)

In this paper, we investigate hands-free speech recognition as front-end system of conversational TV. The conversational TV is one of machine conversation systems to retrieve the interesting information by inquiring it to the TV. To realize the natural machine conversation without consciousness of microphone, hands-free speech recognition is required. In the hands-free speech recognition system, the directions of the arriving signal are estimated by using a microphone array and the desired signal is enhanced by beam forming. Then, the user utterance section is detected automatically from continuously observed signal. Furthermore, by applying the noise reduction and noise adaptation, the enhanced speech signal is recognized accurately.
Near-Real-Time Data Acquisition and Beamforming for UWB See-Through-Wall System (2007)

An ultra-wideband See-Through-Wall (STW) imaging radar system has been developed that could allow the acquisition and processing of the collected radar data in real-time or near-real-time environment. In this paper, we have compared the performance of various Synthetic Aperture Radar image formation methods, and we will demonstrate the wall-correction preliminary results. Additionally, the design of a near-real-time FPGA-based beamforming processor will be presented and samples of our theoretical and experimental collected data.
2019 Novel Coronavirus (2019-nCoV) Pneumonia (2020)

A 41-year-old woman with a travel history to Wuhan, China, where the 2019 novel coronavirus (2019-nCoV) was spreading (1), presented with a 4-day history of fever.Laboratory examinations and chest radiographs were negative.Chest CT (Figure ) showed multifocal ground-glass opacities in the perihilar and subpleural regions of both lungs, a common finding of 2019-nCoV-infected pneumonia (2-5).A throat swab was positive for 2019-nCoV on the real-time reverse transcription polymerase chain reaction assay.The patient was immediately isolated for clinical monitoring.Disclosures of Conflicts of Interest: P.L. disclosed no relevant relationships.X.T.
Conditioning Following Powder Micronization: Influence on Particle Growth of Salbutamol Sulfate (2003)

Micronization is a high-energy process that induces changes in the crystallinity of materials. As a result, the crystalline structures on the particles' surface are being destroyed and amorphous areas are formed. After micronization of salbutamol sulfate to be used in dry powder inhalers, only small amounts of amorphous material are produced. Nevertheless, even these small amounts can have important effects on the physical stability of the powder. The amorphous state is thermodynamically unstable and tends to convert to the stable, crystalline state. The recrystallization process of disordered regions on the particles' surface leads to particle growth of milled particles. In this case, bridges of solid material are being formed between the individual particles, which leads to particle growth. This is an undesirable process, because particles for pulmonary administration are designed to range between 1 and 10 microm in diameter to exert respirative effect. In the present investigation, salbutamol sulfate is micronized by an air jet mill, and the generated products are exposed to different conditions. Thereafter, the best possible conditioning parameters and storage conditions for the micronized salbutamol sulfate are worked out and rated. The aim of this treatise is to demonstrate the importance of conditioning following micronization.
Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate (2011)

mTORC2 (mammalian target of rapamycin complex 2) plays important roles in signal transduction by regulating an array of downstream effectors, including protein kinase AKT. However, its regulation by upstream regulators remains poorly characterized. Although phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) is known to regulate the phosphorylation of AKT Ser(473), the hydrophobic motif (HM) site, by mTORC2, it is not clear whether PtdIns(3,4,5)P(3) can directly regulate mTORC2 kinase activity. Here, we used two membrane-docked AKT mutant proteins, one with and the other without the pleckstrin homology (PH) domain, as substrates for mTORC2 to dissect the roles of PtdIns(3,4,5)P(3) in AKT HM phosphorylation in cultured cells and in vitro kinase assays. In HEK293T cells, insulin and constitutively active mutants of small GTPase H-Ras and PI3K could induce HM phosphorylation of both AKT mutants, which was blocked by the PI3K inhibitor LY294002. Importantly, PtdIns(3,4,5)P(3) was able to stimulate the phosphorylation of both AKT mutants by immunoprecipitated mTOR2 complexes in an in vitro kinase assay. In both in vivo and in vitro assays, the AKT mutant containing the PH domain appeared to be a better substrate than the one without the PH domain. Therefore, these results suggest that PtdIns(3,4,5)P(3) can regulate HM phosphorylation by mTORC2 via multiple mechanisms. One of the mechanisms is to directly stimulate the kinase activity of mTORC2.
Ultra High Capacity Self-Homodyne PON With Simplified ONU and Burst-Mode Upstream (2014)

In this letter, we demonstrate a proof of concept fully loaded bidirectional ultrahigh capacity coherent passive optical network (2 × 1008 × 8.3 Gb/s). This was achieved using partial spectrum overlap, Nyquist shaping, digital frequency shifting, self-homodyne detection, and pilot tone remodulation. Upstream burst mode operation is also demonstrated.
Hierarchical path hunt in a broadband multirate circuit switching fabric (1996)

A circuit switching fabric that switches narrowband (DS0), wideband (N/spl times/DS0, N/spl times/VT), and broadband (STS-N) signals embedded in SONET streams is studied. Based on the Clos (1953) strictly nonblocking principle, the fabric is strictly nonblocking if all path hunts are performed at the basic-rate (DS0 in our case) level. On the other hand, a hierarchical path hunt can speed up the path hunt process for a high bit-rate call, though the fabric will then lose its nonblocking property. We study several hierarchical path hunt algorithms and investigate how the hierarchy impacts the blocking probability. We also study the performance impact resulting from doing broadcast/multicast in a multirate circuit switching fabric. Our results provide insights into how hierarchical path hunts should be designed in a broadband multirate circuit switching fabric.
Clinical Trial of Programmable Implantable Insulin Pump For Type I Diabetes (1992)

Insulin therapy with implantable pumps is effective and safe for periods up to 1.7 yr with a decreased risk of severe hypoglycemia than with intensive subcutaneous insulin therapy.
Improvement in angular color uniformity of white light-emitting diodes using screen-printed multilayer phosphor-in-glass (2014)

Angular color uniformity (ACU) is a key optical property of white light-emitting diodes (WLEDs) and high ACU is strongly demanded in illumination applications. In this paper, a multilayer phosphor-in-glass (PiG), which can be produced by the screen-printing method, is proposed to improve the ACU of LED packages. The screen-printing method provides a feasible scheme to produce multilayer, various-shaped PiG with a controllable pattern. Angular correlated color temperature (CCT) distributions of the LED packages with multilayer PiG are simulated numerically and measured experimentally. Optical performance of the LED package with optimized three-layer cone-shaped PiG is compared with that of packages with two-layer and one-layer PiG. The experimental measurements indicate that the deviation of angular CCT can be reduced from 761 to 171 K by cone-shaped PiG at average CCT of 6000 K. The results demonstrate that higher angular color uniformity can be achieved by LED packages with multilayer cone-shaped PiG.
Designing the future atomic electrocatalyst for efficient energy systems (2020)

Abstract Following the fast development of electrocatalysts, atomic catalysts have surely become the most frontier research topic in energy supply systems. In varied electrochemical reactions, they have displayed untapped potential for practical applications due to the exceptional performances in both electroactivity and selectivity, ultra‐high metal utilization, and flexible substrates. Besides the conventional experimental synthesis strategies and characterization techniques, advanced theoretical calculations and even machine learning algorithms have been introduced to understand and predict the electrocatalysis performances of novel atomic catalysts, supplying the insightful knowledge for the future rational design and synthesis of the atomic catalyst with the desired properties. Therefore, this review will highlight the recent advance achievements in atomic catalysts regarding the atomic catalyst synthesis and applications, covering the mainstream electrochemical process in energy applications. Meanwhile, we also summarize the application of advanced theoretical explorations as valuable references for future electrocatalyst design. Moreover, we will summarize the existing challenges for the practical applications and the prospects of present atomic catalysts.
Water-soluble polymerization initiators based on the thioxanthone structure: a spectroscopic and laser photolysis study (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWater-soluble polymerization initiators based on the thioxanthone structure: a spectroscopic and laser photolysis studyD. J. Lougnot, C. Turck, and J. P. FouassierCite this: Macromolecules 1989, 22, 1, 108–116Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://doi.org/10.1021/ma00191a022RIGHTS & PERMISSIONSArticle Views516Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats. (1994)

Little information is available on proteolytic pathways responsible for muscle wasting in cancer cachexia. Experiments were carried out in young rats to demonstrate whether a small (< 0.3% body weight) tumor may activate the lysosomal, Ca(2+)-dependent, and/or ATP-ubiquitin-dependent proteolytic pathway(s) in skeletal muscle. Five days after tumor implantation, protein mass of extensor digitorum longus and tibialis anterior muscles close to a Yoshida sarcoma was significantly reduced compared to the contralateral muscles. According to in vitro measurements, protein loss totally resulted from increased proteolysis and not from depressed protein synthesis. Inhibitors of lysosomal and Ca(2+)-dependent proteases did not attenuate increased rates of proteolysis in the atrophying extensor digitorum longus. Accordingly, cathepsin B and B+L activities, and mRNA levels for cathepsin B were unchanged. By contrast, ATP depletion almost totally suppressed the increased protein breakdown. Furthermore, mRNA levels for ubiquitin, 14 kDa ubiquitin carrier protein E2, and the C8 or C9 proteasome subunits increased in the atrophying muscles. Similar adaptations occurred in the muscles from cachectic animals 12 days after tumor implantation. These data strongly suggest that the activation of the ATP-ubiquitin-dependent proteolytic pathway is mainly responsible for muscle atrophy in Yoshida sarcoma-bearing rats.