gebhart/patrepeval huggingface dataset:
<title>Application Of Zone Plates To Alignment In X-Ray Lithography</title> (1982)

Zone plates are patterned areas with imaging properties. When printed on masks and wafers and suitably illuminated, they form high contrast images which are useful for alignment in microlithography. As with holograms, defects in the pattern arising from variations in processing and linewidth control and poor edge definition degrade the images only marginally. This paper describes the use of zone plates for automatic alignment in X-ray proximity printing. The best signal to noise ratios (important in automatic alignment) are obtained by using the zone plates to focus laser beams to nearly diffraction limited point sources. With zone plates approximately 100 microns in diameter and 300 microns focal length, we have obtained signal to noise ratios greater than 100 to 1 and position accuracies better than ±0.1 micron. In addition our geometry is chosen so that magnification errors in the mask or wafer up to ~1 micron are automatically compensated. A microprocessor based system is described which performs the alignment automatically.
A robust dataset-agnostic heart disease classifier from Phonocardiogram (2017)

Automatic classification of normal and abnormal heart sounds is a popular area of research. However, building a robust algorithm unaffected by signal quality and patient demography is a challenge. In this paper we have analysed a wide list of Phonocardiogram (PCG) features in time and frequency domain along with morphological and statistical features to construct a robust and discriminative feature set for dataset-agnostic classification of normal and cardiac patients. The large and open access database, made available in Physionet 2016 challenge was used for feature selection, internal validation and creation of training models. A second dataset of 41 PCG segments, collected using our in-house smart phone based digital stethoscope from an Indian hospital was used for performance evaluation. Our proposed methodology yielded sensitivity and specificity scores of 0.76 and 0.75 respectively on the test dataset in classifying cardiovascular diseases. The methodology also outperformed three popular prior art approaches, when applied on the same dataset.
Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders (2019)

Hematopoietic stem cell (HSC) gene therapy is being evaluated for hemoglobin disorders including sickle cell disease (SCD). Therapeutic globin vectors have demanding requirements including high-efficiency transduction at the HSC level and high-level, erythroid-specific expression with long-term persistence. The requirement of intron 2 for high-level β-globin expression dictates a reverse-oriented globin-expression cassette to prevent its loss from RNA splicing. Current reverse-oriented globin vectors can drive phenotypic correction, but they are limited by low vector titers and low transduction efficiencies. Here we report a clinically relevant forward-oriented β-globin-expressing vector, which has sixfold higher vector titers and four to tenfold higher transduction efficiency for long-term hematopoietic repopulating cells in humanized mice and rhesus macaques. Insertion of Rev response element (RRE) allows intron 2 to be retained, and β-globin production is observed in transplanted macaques and human SCD CD34<sup>+</sup> cells. These findings bring us closer to a widely applicable gene therapy for hemoglobin disorders.
Synthesizing computer generated holograms with reduced number of perspective projections (2007)

We present an improved method for recording a synthesized Fourier hologram under incoherent white-light illumination. The advantage of the method is that the number of real projections needed for generating the hologram is significantly reduced. The new method, designated as synthetic projection holography, is demonstrated experimentally. We show that the synthetic projection holography barely affects the reconstructed images. However, by increasing the number of observed projections one can improve the synthetic projection hologram quality.
Recognition of living fingers with a sensor based on scattered-light detection (2006)

To prevent fraud by use of replicas of human fingers for identity verification, we propose to check variations in color and in a series of previously acquired fingerprint images. Movement of a finger on a human hand induces blood movement, and light scattered inside the finger carries this life-related information. In experiments, we found characteristic changes in color and luminance extracted from the central parts of fingerprint images. Some criteria for recognition of living tissue were tested with input provided by more than 30 participants. Inasmuch as the response of a human body to an external stimulus can be checked by our method with no additional components, this technology can raise the security level of a fingerprint identification system.
Photorechargeable High Voltage Redox Battery Enabled by Ta<sub>3</sub>N<sub>5</sub> and GaN/Si Dual‐Photoelectrode (2017)

Solar rechargeable battery combines the advantages of photoelectrochemical devices and batteries and has emerged as an attractive alternative to artificial photosynthesis for large-scale solar energy harvesting and storage. Due to the low photovoltages by the photoelectrodes, however, most previous demonstrations of unassisted photocharge have been realized on systems with low open circuit potentials (<0.8 V). In response to this critical challenge, here it is shown that the combined photovoltages exceeding 1.4 V can be obtained using a Ta<sub>3</sub> N<sub>5</sub> nanotube photoanode and a GaN nanowire/Si photocathode with high photocurrents (>5 mA cm<sup>-2</sup> ). The photoelectrode system makes it possible to operate a 1.2 V alkaline anthraquinone/ferrocyanide redox battery with a high ideal solar-to-chemical conversion efficiency of 3.0% without externally applied potentials. Importantly, the photocharged battery is successfully discharged with a high voltage output.
Abstract LB-257: Profiling the effects of IDH1 and IDH2 mutants on the glioma cell metabolome (2011)

Abstract Somatic hotspot mutations in the NADP+-dependent isocitrate dehydrogenases, IDH1 and IDH2, arise frequently in gliomas. These gliomas include WHO grades II and III oligodendrogliomas and astrocytomas, as well as WHO grade IV secondary glioblastomas. When mutated, IDH1 and IDH2 gain the ability to produce (R)-2-hydroxyglutarate (2HG) and may dominant-negatively inhibit IDH1-WT. Aside from these specific functions, the downstream effect of these metabolic enzyme mutations on cellular metabolism is unknown. To identify metabolic alterations caused by IDH1 and IDH2 mutants, we used three mass spectrometry methods (GC-MS/MS, LC-MS/MS +ESI, and LC-MS/MS -ESI) to profile &gt;200 biochemicals in lysates of human oligodendroglial cell line (HOG) cells that homologously express IDH1-R132H or IDH2-R172K, which are the most frequent IDH1 and IDH2 mutants in glioma, respectively. To determine whether 2HG production or inhibition of IDH1-WT could mediate similar effects on cellular metabolism as IDH mutant expression, we also analyzed cells treated cells with either 7.5mM or 30mM 2HG as well as cells with stable shRNA knockdown of endogenous IDH1-WT. Unsupervised hierarchical clustering, univariate threshold tests, correlation analysis, and principal component analysis revealed that cells expressing IDH1-R132H and IDH2-R172K have similar metabolite profiles, and that 2HG treatment also results in a similar profile. However, cell with shRNA IDH1 knockdown shared few metabolic features with cells expressing IDH mutants. Metabolite set enrichment analyses revealed that numerous amino acids, N-acetylated amino acids, TCA cycle metabolites, glutathione metabolites, and choline derivatives were markedly altered in IDH-mutant expressing cells. Strikingly, we found that N-acetyl-aspartyl-glutamate (NAAG), a common brain metabolite, is 50-fold reduced in cells expressing IDH1-R132H and &gt;2-fold reduced in human glioma tissues with IDH1-R132H compared to glioma tissues without IDH mutations. This work shows that IDH mutants can induce widespread cellular metabolic changes. Additionally, the metabolites that were found to be altered in this study may play a role in glioma pathogenesis and may be useful for diagnosis or treatment for gliomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-257. doi:10.1158/1538-7445.AM2011-LB-257
High‐resolution, energy‐dispersive microcalorimeter spectrometer for X‐ray microanalysis (1997)

We have developed a prototype X‐ray microcalorimeter spectrometer with high energy resolution for use in X‐ray microanalysis. The microcalorimeter spectrometer system consists of a superconducting transition‐edge sensor X‐ray microcalorimeter cooled to an operating temperature near 100 mK by a compact adiabatic demagnetization refrigerator, a superconducting quantum interference device current amplifier followed by pulse‐shaping amplifiers and pileup rejection circuitry, and a multichannel analyser with computer interface for the real‐time acquisition of X‐ray spectra. With the spectrometer mounted on a scanning electron microscope, we have achieved an instrument response energy resolution of better than 10 eV full width at half‐maximum (FWHM) over a broad energy range at real‐time output count rates up to 150 s −1 . Careful analysis of digitized X‐ray pulses yields an instrument‐response energy resolution of 7.2 ± 0.4 eV FWHM at 5.89 keV for Mn Kα 1,2 X‐rays from a radioactive 55 Fe source, the best reported energy resolution for any energy‐dispersive detector.
Robotic clicker training (draft) (2002)

In this paper we want to propose the idea that some techniques used for animal training might be helpful for solving human robot interaction problems in the context of entertainment robotics. We present a model for teaching complex actions to an animal-like autonomous robot based on ”clicker training”, a method used efficiently by professional trainers for animals of different species. After describing our implementation of clicker training on an enhanced version of AIBO, Sony’s four-legged robot, we argue that this new method can be a promising technique for teaching unusual behavior and sequences of actions to a pet robot.
Show and Recall: Learning What Makes Videos Memorable (2017)

With the explosion of video content on the Internet, there is a need for research on methods for video analysis which take human cognition into account. One such cognitive measure is memorability, or the ability to recall visual content after watching it. Prior research has looked into image memorability and shown that it is intrinsic to visual content, but the problem of modeling video memorability has not been addressed sufficiently. In this work, we develop a prediction model for video memorability, including complexities of video content in it. Detailed feature analysis reveals that the proposed method correlates well with existing findings on memorability. We also describe a novel experiment of predicting video sub-shot memorability and show that our approach improves over current memorability methods in this task. Experiments on standard datasets demonstrate that the proposed metric can achieve results on par or better than the state-of-the art methods for video summarization.
3D image fusion and guidance for computer-assisted bronchoscopy (2005)

The standard procedure for diagnosing lung cancer involves two stages. First, the physician evaluates a high-resolution three-dimensional (3D) computed-tomography (CT) chest image to produce a procedure plan. Next, the physician performs bronchoscopy on the patient, which involves navigating the the bronchoscope through the airways to planned biopsy sites. Unfortunately, the physician has no link between the 3D CT image data and the live video stream provided during bronchoscopy. In addition, these data sources differ greatly in what they physically give, and no true 3D planning tools exist for planning and guiding procedures. This makes it difficult for the physician to translate a CT-based procedure plan to the video domain of the bronchoscope. Thus, the physician must essentially perform biopsy blindly, and the skill levels between different physicians differ greatly. We describe a system that enables direct 3D CT-based procedure planning and provides direct 3D guidance during bronchoscopy. 3D CT-based information on biopsy sites is provided interactively as the physician moves the bronchoscope. Moreover, graphical information through a live fusion of the 3D CT data and bronchoscopic video is provided during the procedure. This information is coupled with a series of computer-graphics tools to give the physician a greatly augmented reality of the patient's interior anatomy during a procedure. Through a series of controlled tests and studies with human lung-cancer patients, we have found that the system not only reduces the variation in skill level between different physicians, but also increases biopsy success rate.
Laser performance of LiSrAlF6:Cr3+ (1989)

We have lased the new material, LiSrAlF6:Cr3+ (Cr3+:LiSAF). The single crystals were grown by the horizontal zone melting technique. The spectroscopic properties of Cr3+:LiSAF are similar to those of other low-field Cr3+-doped systems, although the emission cross section is strongly π polarized and is also somewhat larger than has been measured for other fluoride hosts. The free-running lasing wavelength of Cr3+:LiSAF is 825 nm, and the tuning range extends from at least 780 to 920 nm. Using Kr laser pumping, we obtained slope efficiencies of 36% and 14% by utilizing output couplings of 4.8% and 0.8%, respectively. On the basis of these results, the extrapolated maximum efficiency of 53% is determined, to be compared to the quantum defect-limited value of 78%. It is concluded that a moderate level of excited state absorption (ESA) loss is responsible for the reduced efficiency of the Cr3+:LiSAF system. This contrasts with the related results previously obtained for LiCaAlF6:Cr3+, where it was concluded that the effects of ESA were negligible [IEEE J. Quantum Electron. QE-24, 2243 (1988)].
Quality improvement of spray-dried, protein-loaded d, l-PLA microspheres by appropriate polymer solvent selection (1995)

The aim was to study the effect of the type of polymer solvent on characteristics of microspheres produced by spray drying. The water-soluble model protein, bovine serum albumin (BSA) was microencapsulated into biodegradable poly(D,L-lactic acid) using the following 10 different polymer solvents: acetaldehyde dimethyl acetal, acetone, dichloromethane, dioxane, ethyl acetate, ethyl vinyl ether, nitromethane, tetrahydrofuran, 1,1,1-trichloroethane, and 1,1,2-trichloroethylene. These solvents having similar toxicity levels differ greatly in their physico-chemical characteristics such as boiling point, vapour pressure, miscibility and interfacial tension with an aqueous phase, and solubility parameter. The effect of these solvents on microsphere morphology was studied by SEM-micrographs. Regular particle morphology was obtained when dichloromethane, ethyl acetate, or nitromethane was used as the polymer solvent, whereas the trichlorinated solvents, tetrahydrofuran, and dioxane produced a substantial number of coalesced particles. The results are interpreted in terms of boiling point, vapour pressure, and polymer-solvent affinity. Further, BSA-loading and -integrity in the microspheres, and burst release were analysed. The theoretical loading of 2.9% was attained with dichloromethane, ethyl acetate and nitromethane, in agreement with observations of particle morphology. HPLC- and SDS-PAGE analysis of the microencapsulated BSA did not show any protein degradation or dimerization, whereas solid-phase ELISA clearly revealed that the in vitro protein antigenicity was substantially reduced (50%), particularly by water miscible solvents. Dichloromethane and ethyl acetate did not show any detrimental effect on protein antigenicity. Finally, burst release could be related again to particle morphology, with dichloromethane and nitromethane giving a burst release of only 5%. In conclusion, dichloromethane, ethyl acetate and nitromethane proved to be the most suitable solvents for the polymer-protein system studied.
A single-chip programmable digital CMOS imager with enhanced low-light detection capability (2002)

The advent of high performance imaging in CMOS technology using active pixel sensors has enabled ultra-low power, miniature, single-chip, digital camera systems. We report at fully digital, programmable, 5-wire, large format (512/spl times/512) camera-on-a-chip that integrates the imager array, control logic, ADC, and bias generation on the same chip. The chip runs off a single (3.3 V) power supply, consumes only 10 mW, is capable of electronic panning, and produces high quality images with a low noise of <40 e/sup -/, and excellent response linearity down to read noise levels.
Motion correction using the <i>k</i>‐space phase difference of orthogonal acquisitions (2002)

Rigid body translations of an object in MRI create image artifacts along the phase-encode (PE) direction in standard 2DFT imaging. If two images are acquired with swapped PE direction, it is possible to determine and correct for arbitrary in-plane translational interview motions in both images directly from phase differences in the k-space acquisitions by solving a large system of linear equations. For example, if one assumes two N x N 2D acquisitions with in-plane translational interview motion, 4N unknown motions may corrupt the two images, but the phase difference at each point in k-space yields a system of N(2) equations in these 4N unknowns. If the acquisitions have orthogonal PE directions, this highly overdetermined system of equations can be solved to provide the motion records, which in turn can be used to correct the motion artifacts in each image. The theory of this orthogonal k-space phase difference (ORKPHAD) technique is described, and results are presented for synthetic and in vivo motion-corrupted data sets. In all cases, the data showed clear improvement of translation-induced artifacts. These methods do not require special pulse sequences and are theoretically generalizable to partial Fourier imaging and 3D acquisitions.
Local At-Speed Scan Enable Generation for Transition Fault Testing Using Low-Cost Testers (2007)

At-speed testing is becoming crucial for modern very-large-scale-integration systems, which operate at clock speeds of hundreds of megahertz. In a scan-based test methodology, it is common to use a transition delay fault model for at-speed testing. The launching of the transition can be done either in the last cycle of scan shift [launch-off-shift (LOS)], or in a functional launch cycle that follows the scan shift and precedes the fast capture [launch-off-capture (LOC)]. The LOS technique offers significant advantages over the LOC in terms of coverage and pattern count, but since it requires the scan enable (SEN) signal to change state in the time period of one functional clock cycle, considerable engineering resources are required to close the timing on the SEN signal. Low-cost testers will not be able to provide the at-speed SEN signal as required by the LOS technique. We propose a scan-based at-speed methodology that generates local SEN signals that are guaranteed to switch in one functional clock cycle even when the external SEN signal does not change state at functional speed. Our technique is based on encapsulating the SEN control signal in the scan test data. A new scan cell, which is called the last transition generator, must be inserted in every scan chain for generating internal SEN signals. The proposed method is robust, practical, and readily implemented using commercial tools available today
MethylScreen: DNA Methylation Density Monitoring using Quantitative PCR (2007)

Aberrant gene silencing of genes through cytosine methylation has been demonstrated during the development of many types of cancers including prostate cancer Several genes including GSTP1 have been shown to be methylated in prostate cancer leading to the suggestion and demonstration that methylation status of such genes could be used as cancer diagnosis markers alone or in support of histology. We developed a bisulfite-free alternative, MethylScreen technology, an assay for DNA methylation detection utilizing combined restriction from both methylation-sensitive restriction enzymes (MSRE) and methylation-dependent restriction enzymes (MDRE). MethylScreen was used to analyze the 5' region of GSTP1 in cell lines, in vitro methylated DNA populations, and flash-frozen tissue samples in an effort to characterize the output and analytical performance characteristics of the assay. The output from the quantitative PCR assay suggested that it could not only detect fully methylated molecules in a mixed population below the 1% level, but it could also quantify the abundance of intermediately methylated molecules. Interestingly, the interpreted output from the four quantitative PCRs closely resembled the molecular population as described by clone-based bisulfite genomic sequencing.
Materials for Phase Holographic Storage. (1973)

Abstract : The report describes recent advances in the understanding and performance of iron-doped lithium niobate as a holographic-storage medium. The major results reported here are: (a) the identification of a self-consistent model for hologram storage, fixing, and erasure in this material; (b) a theoretical analysis using this model concerning methods for improving the sensitivity and fixing performance; and (c) the development and refinement of new crystal preparation techniques. As a result of these efforts, significant advances have been made in the performance of Fe-doped LiNbO3 for both read-only and read-write applications. In addition, preliminary results are presented on a new storage material, photochromic lithium niobate. (Author)
Observations of delayed all-optical routing in a slow-light regime (2008)

We report the observation of a delayed all-optical routing using an ultraslow-light phenomenon in a defected solid medium. Unlike simultaneously enhanced slow-light-based four-wave mixing processes, the present observation demonstrates on-demand delayed all-optical routing via the direct retrieval of atomic coherence strongly coupled with the slow light.