gebhart/patrepeval huggingface dataset:
A multiple-row transistor placement system for full custom design (2005)

This paper presents a multiple-row transistor placement system for full custom design. The system is flexible in supporting a wide variety of process technologies and a range of library template styles. This automatic transistor placer provides many options for users to customize their layouts. Transistor folding, transistor pairing, transistor chaining, row partitioning, and transistor placement are integrated into this system for the generation of high-performance, dense, design-rule correct layouts. In addition, a high level stick diagram, enabling gate swapping, splitting and merging gives layout designers the ability to perform manual optimization without the need to prepare different sizes of gate transistors for supporting these device manipulations. Experimental results indicate that the automatic generated transistor layouts are competitive with manually designed layouts in terms of execution time and the numbers of diffusion breaks.
Voltage monitoring and control for enhanced utilization of power grids (2005)

Transmission operators in deregulated power markets are increasing the utilization of the transmission system with a minimum of investment in new infrastructure. This trend leads to smaller safety margins and increased risk of system wide power blackouts. This work presents results from a collaborative R&D effort by a research institute, a transmission company, and an industry company, with the objective to increase power transfer limits with the use of sophisticated control algorithms and advanced measurement technologies. A prototype voltage instability predictor (VIP) terminal, and a centralized control scheme for dynamic reactive resources have been implemented and tested in a real 420 kV power transmission grid.
Abstract 5466: The Mdm2 inhibitor, NVP-CGM097, in combination with the BRAF inhibitor NVP-LGX818 elicits synergistic antitumor effects in melanoma (2014)

Abstract RAF kinase inhibitors have shown substantial therapeutic effects in patients with BRAF-mutant melanoma. However, despite impressive initial responses, therapeutic effects are often temporary due to acquired resistance. This resistance highlights the need to identify therapeutic approaches to improve the durability of responses to RAF inhibitors. In this study, we demonstrate that a novel inhibitor of p53-Mdm2 interaction, NVP-CGM097, causes marked reduction of melanoma cell viability. The activation of p53 signaling and consequent reduction in cell viability required wild-type p53, but was independent of BRAF status. Moreover, combined inhibition of Mdm2, using NVP-CGM097, and BRAF using NVP-LGX818, synergistically inhibited the viability of BRAF mutant melanoma cells in vitro and tumor growth in vivo. NVP-CGM097 caused induction of p21 and Bax, while NVP-LGX818 did not. Instead, NVP-LGX818 caused induction of p27 and Bim. Therefore, together they induced a complementary set of anti-proliferative and apoptosis stimulating molecules, which resulted in strong synergistic antitumor effects. In vivo, the combination treatment resulted in sustained tumor regressions and markedly prolonged survival relative to either single agent. Collectively, these data show that activation of p53, through inhibition of Mdm2, leads to antitumor effects in melanoma. Furthermore, the data show that concomitant activation of tumor suppressor p53 and inhibition of BRAF synergistically suppresses melanoma growth. Therefore, combined inhibition of Mdm2 and BRAF in melanoma may provide an effective therapeutic modality capable of overcoming the resistance observed with the BRAF inhibitor monotherapy and thus lead to more durable responses in the clinic. Citation Format: Hui Qin Wang, Matthew Zubrowski, Erling Emerson, Elina Pradhan, Sébastien Jeay, Marion Wiesmann, Giordano Caponigro, Jens Wuerthner, Robert Schlegel, Z. Alexander Cao, Alan Huang, Ensar Halilovic. The Mdm2 inhibitor, NVP-CGM097, in combination with the BRAF inhibitor NVP-LGX818 elicits synergistic antitumor effects in melanoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5466. doi:10.1158/1538-7445.AM2014-5466
Hepatocyte–Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma (2012)

Many solid malignant tumors arise on a background of inflamed and/or fibrotic tissues, features that are found in more than 80% hepatocellular carcinomas (HCC). Activated hepatic stellate cells (HSC) play a critical role in fibrogenesis associated with HCC onset and progression, yet their functional impact on hepatocyte fate remains largely unexplored. Here, we used a coculture model to investigate the cross-talk between hepatocytes (human hepatoma cells) and activated human HSCs. Unsupervised genome-wide expression profiling showed that hepatocyte-HSC cross-talk is bidirectional and results in the deregulation of functionally relevant gene networks. Notably, coculturing increased the expression of proinflammatory cytokines and modified the phenotype of hepatocytes toward motile cells. Hepatocyte-HSC cross-talk also generated a permissive proangiogenic microenvironment, particularly by inducing VEGFA and matrix metalloproteinase (MMP)9 expression in HSCs. An integrative genomic analysis revealed that the expression of genes associated with hepatocyte-HSC cross-talk correlated with HCC progression in mice and was predictive of a poor prognosis and metastasis propensity in human HCCs. Interestingly, the effects of cross-talk on migration and angiogenesis were reversed by the histone deacetylase inhibitor trichostatin A. Our findings, therefore, indicate that the cross-talk between hepatoma cells and activated HSCs is an important feature of HCC progression, which may be targeted by epigenetic modulation.
A decision-theoretic approach to call admission control in ATM networks (1995)

This paper describes a simple and robust ATM call admission control, and develops the theoretical background for its analysis. Acceptance decisions are based on whether the current load is less than a precalculated threshold, and Bayesian decision theory provides the framework for the choice of thresholds. This methodology allows an explicit treatment of the trade-off between cell loss and call rejection, and of the consequences of estimation error. Further topics discussed include the robustness of the control to departures from model assumptions, its performance relative to a control possessing precise knowledge of all unknown parameters, the relationship between leaky bucket depths and buffer requirements, and the treatment of multiple call types.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Story of e: <i>e The Story of a Number</i> (1995)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Eli Maor, Katherine R. Sopka; The Story of e: e The Story of a Number. Phys. Teach. 1 November 1995; 33 (8): 540. https://doi.org/10.1119/1.2344290 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersThe Physics Teacher Search Advanced Search |Citation Search
Shear and Bending Response of a Rigid Plastic Circular Plate Struck Transversely by a Mass* (1996)

ABSTRACT A theoretical analysis is presented for the dynamic plastic behavior of a fully clamped rigid, perfectly plastic circular plate struck transversely by a rigid mass at the center. It is shown that the maximum permanent transverse deformation predicted by a theoretical solution, with combined transverse shear and bending, is similar to that from a bending-only solution when the ratio of shear strength to bending capacity υ is sufficiently large. However, when the strength parameter υ is small, the transverse shear deformation dominates the response and the maximum deformation from a combined shear and bending solution increases sharply with a decrease in υ. It is also found that the transverse shear deformation becomes more important with an increase in the dimensionless mass ratio β and is sensitive to the dimensionless radius ρ0 of the impact area.
Kautschuktechnologie (2013)

You have accessKautschuk TechnologieOct 2013KautschuktechnologieFritz Röthemeyer, Franz SommerFritz Röthemeyer, Franz Sommerhttps://doi.org/10.3139/9783446437609.fmSectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn next chapter FiguresReferencesRelatedDetails 2013Pages: I-XXXIIIPrint ISBN: 978-3-446-43776-0eISBN: 978-3-446-43760-9 Copyright & Permissions© 2013 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Design of Security Access Control System of Adaptive Wireless Gateway (2008)

In this paper, we analyze the 802.1x access control protocol and the firewall packet filtering strategy, as well as elaborated how to design the security access control system of the adaptive wireless gateway in the aspect of the port control, bi-directional user certificate authentication and packet filtering. Furthermore, the experimental results showed that this system has higher security.
Jurnal Avogadro Jurusan Kimia FMIPA Universitas Cenderawasih (2020)

AVOGADRO Jurnal Kimia merupakan jurnal ilmiah yang diterbitkan oleh Jurusan Kimia FMIPA Universitas Cenderwasih Jayapura Papua. Susunan pengelola Jurnal terdiri atas penanggung jawab Ketua Jurusan Kimia FMIPA Universitas Cenderawasih. AVOGADRO Jurnal Kimia merupkam jurnal ilmiah yang ditujukan untuk publikasi penelitian dan pegembangan dalam bidang kimia, seperti kimia organik, kimia kimia anorganik, kimia analitik, kimia fisik, biokimia dan pengajaran kimia serta bidang lain yang berkaitan. Artikel dapat berupa hasil-hasil penelitian, kajian ilmiah dan analisis serta pemecahan permasalahan di bidang kimia yang relevan. AVOGADRO Jurnal Kimia terbit dua kali setiap tahun yaitu pada bulan Mei dan November, memuat tentang artikel ilmiah dalam bidang ilmu kimia teori dan terapan serta ilmu-ilmu yang serumpun.
Transdermal buprenorphine in the management of persistent pain - safety aspects. (2006)

By virtue of their efficacy, opioid analgesics have long been used for the treatment of both acute and chronic pain. Concerns regarding their safety and tolerability have frequently prevented this class of drugs achieving their full therapeutic potential, and their reported association with drug abuse and dependence has led to a reduced acceptance by many patients. Indeed, there is a variety of opioid-like side effects which are common to all members of the class, but some opioids have a more favourable safety profile than others. Buprenorphine is a semisynthestic opioid with a mu-agonistic and kappa-antagonistic receptor-binding profile. Studies over the past two decades have shown buprenorphine to have a complex and unique pharmacological profile, which results in enhanced therapeutic benefits combined with a favourable safety profile. Having been underused before, the development of a new transdermal drug delivery system for buprenorphine has revived interest in this substance. Transdermal buprenorphine (Gruenenthal GmbH, Aachen, Germany) provides a noninvasive method of rate-controlled drug release ensuring constant and predictable serum buprenorphine levels over a prolonged period. This preparation has been shown to be advantageous for long-term treatment of chronic pain patients providing reliable pain control, few adverse events, and good patient acceptance.
Discrete all-pole modeling (1991)

A method for parametric modeling and spectral envelopes when only a discrete set of spectral points is given is introduced. This method, called discrete all-pole (DAP) modeling, uses a discrete version of the Itakura-Saito distortion measure as its error criterion. One result is an autocorrelation matching condition that overcomes the limitations of linear prediction and produces better fitting spectral envelopes for spectra that are representable by a relatively small discrete set of values, such as in voiced speech. An iterative algorithm for DAP modeling that is shown to converge to a unique global minimum is presented. Results of applying DAP modeling to real and synthetic speech are also presented. DAP modeling is extended to allow frequency-dependent weighting of the error measure, so that spectral accuracy can be enhanced in certain frequency regions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
THE RELATIONSHIP BETWEEN SURFACE CHARGE (POTENTIAL CHARACTERISTICS) OF THE VASCULAR INTERFACE AND THROMBOSIS (1983)

Thus, it can be shown that highly theoretical experiments carried out to evaluate the electrochemistry of thrombosis can also be shown to have significance in the generation of new products, which relates the scientific findings to successful modern prosthesis and medically useful devices.
Finite element analysis of single crystal tuning forks for gyroscopes (2002)

The single crystal tuning fork gyroscopes are analyzed by using the finite element method. The vibrational displacements of the gyroscope are calculated. As the calculated results of an x-cut quartz crystal tuning fork, whose base length is equal to the arm length, it becomes clear as the following. (1) For the horizontal driving mode, the displacements at the bottom of the base are below 1/1000 times as compared with the maximum displacement at the arm end. (2) For the vertical detecting made, the displacements at the base bottom are almost equal to 1/10 times in comparison with the maximum value. The validity of calculated result is experimentally confirmed. Then, the experimental results of the sensitivity and the response characteristics of the crystal gyroscope are shown.
B Cell Dysfunction Associated With Aging and Autoimmune Diseases (2019)

Impaired humoral responses, as well as an increased propensity for autoimmunity, play an important role in the development of immune system dysfunction associated with aging. Accumulation of a subset of atypical B cells, termed age-associated B cells (ABCs), is one of the key age-related changes in B cell compartments. ABCs are characterized by their distinct phenotypes, gene expression profiles, special survival requirements, variations in B cell receptor repertoires, and unique functions. Here, we summarize recent progress in the knowledge base related to the features of ABCs, their potential role in immune senescence, and their relationship with autoimmune diseases.
Selective laser melting of an advanced Al-Al2O3 nanocomposite (2017)

Selective laser melting (SLM) has been widely used to manufacture customised metallic parts because it provides an integrated way to manufacture three-dimensional (3D) parts from computer-aided design models after several sub-processes. On the other hand, aluminium-based nanocomposites are widely used in the aerospace and automotive industries due to their light weight, high specific strength, excellent wear resistance, but their manufacturability and mechanical properties are not well understood when these new materials are employed in SLM. This is an important consideration because, compared with traditional manufacturing technologies, SLM offers the ability to manufacture engineering parts with very complex geometries by employing a layer-by-layer manufacturing principle. Hence, this thesis systematically studies the SLM of an advanced Al-Al2O3 nanocomposite that is synthesised using high-energy ball-milling (HEBM) process.\nThe aim of this study is to use SLM to fabricate a nearly full dense Al-Al2O3 nanocomposite composed of 96 vol.% Al and 4 vol.% Al2O3 powder. The synthesis and characterisation of ball-milled powder is the first contribution of this study, which also investigates the influence of milling and pause duration on the fabrication of ball-milled composite powder. The second contribution of this work is the development of a 3D finite element model to predict the thermal behaviour of the first layer’s composite powder. Both the transient temperature distribution and molten pool dimensions are predicted within the laser scanning, which\nVI\nenables a more efficient selection of the process parameters (e.g. hatch spacing and scanning speed).\nThe third contribution of this study is the optimisation of the SLM process parameters and microstructure investigation of the fabricated samples. The optimum laser energy density and scanning speed that are used to fabricate nearly full dense Al-Al2O3 nanocomposites are found to be 317.5 J/mm3 and 300 mm/s, respectively. The relative density is evaluated by quantifying the porosity on both the horizontal and vertical sections. The fabricated composite parts were observed to exhibit a very fine granular-dendrite microstructure due to the rapid cooling, while the thermal gradient at the molten pool region along the building direction was found to facilitate the formation of columnar grains.\nThe final contribution of this study is the investigation of mechanical properties such as tensile strength, microhardness and macro and nanoscale wear behaviour. Compared to pure Al, the addition of 4 vol.% Al2O3 nanoparticulates was found to contribute to a 36.3% and 17.5% increase in the yield strength and microhardness of the composite samples, respectively. Cold working was found to contribute to a 39% increase in microhardness due to grain deformation. The pin-on-disc wear testing and atomic force microscopy (AFM) nanoscratching were performed to study the macro and nanoscale wear behaviour of the fabricated samples, respectively.
Delayed Extraction Improves Specificity in Database Searches by Matrix-assisted Laser Desorption/Ionization Peptide Maps (1996)

Peptide mass maps obtained by matrix-assisted laser desorption ionization (MALDI) are an attractive means to identify proteins by searches in sequence databases. Here we demonstrate that the recently introduced delayed ion-extraction technique, when coupled to reflectron MALDI time-of-flight mass spectrometry, leads to dramatically improved search specificity. Routine resolution in the range of 6,000 to 12,000 allows assignment of monoisotopic masses throughout the peptide mass range. Database searches can be performed with high precision by use of a mass accuracy which is currently better than 30 ppm over a wide mass range and better than 5 ppm for a narrow mass range. This high performance makes it possible to identify proteins with fewer peptide masses than before. Additional low intensity peaks can be assigned after a search because of the improved signal-to-noise ratio of delayed-extraction peptide mass spectra, increasing sequence coverage of matched proteins. The improvements in database search specificity can be used to identify the components of simple protein mixtures. In combination with advanced sample preparation and automation techniques, delayed-extraction MALDI time-of-flight mass spectrometry is now an extremely powerful tool for the database identification of proteins.
Algorithm for extraction of pitch and pitch salience from complex tonal signals (1982)

A procedure is described for the automatic extraction of the various pitch percepts which may be simultaneously evoked by complex tonal stimuli. The procedure is based on the theory of virtual pitch, and in particular on the principle, that the whole pitch percept is dependent both on analytic listening (yielding spectral pitch), and on holistic perception (yielding virtual pitch). The more or less ambiguous pitch percept governed by these two pitch modes is described by two pitch patterns: the spectral-pitch pattern, and the virtual-pitch pattern. Each of these patterns consists of a number of pitch (height) values, and associated weights, which account for the relative prominence of every individual pitch. The spectral-pitch pattern is constructed by spectral analysis, extraction of tonal components, evaluation of masking effects (masking and pitch shifts), and weighting according to the principle of spectral dominance. The virtual-pitch pattern is obtained from the spectral-pitch pattern by an advanced algorithm of subharmonic coincidence assessment. The procedure is based on a previous algorithm for calculating virtual pitch [E. Terhardt, Hear. Res. 1, 155–182 (1979)], and can be regarded as a generalized and advanced version thereof.
Die Kristallstruktur von α‐(tert‐Butyloxycarbonylamino)isobuttersäure (1980)

Abstract N‐(tert ‐Butyloxycarbonyl)‐2‐methylalanin kristallisiert aus Essigester/Petrolether in monoklinen Kristallen der Raumgruppe P2 1 /c , mit a = 1085; b = 1099; c = 1172 pm, β = 122.0° und Z = 4. Je zwei antiparallel angeordnete Moleküle bilden intermolekulare Wasserstoffbrückenbindungen zwischen der Urethancarbonyl‐ und der Carboxygruppe in Form von 14gliedrigen Ringen. Diese wechselseitig etwas gegeneinander geneigten, ungefähr in der Ebene (010) liegenden Ringe sind in Richtung [010] wiederum über intermolekulare Wasserstoffbrückenbindungen zwischen den 2‐Methylalanin‐CO‐ und ‐NH‐Gruppen vernetzt. Die dadurch resultierenden Schichten werden untereinander durch hydrophobe Wechselwirkungen der sich jeweils gegenüberstehenden tert ‐Butylgruppen zusammengehalten.
Hyperspectral Remote Sensing: Principles and Applications (2007)

Preface History and Description of Hyperspectral Imaging Spectral Radiometry Imaging Spectrometers: Operational Considerations Hyperspectral Remote Sensing and the Atmosphere Information Extraction from Optical Image Data Hyperspectral and Ultraspectral Information Extraction Approaches Agricultural Applications Environmental Applications Forestry Applications Geology Applications Index
Simulation of bionic electrolocation sensor based on weakly electric fish (2009)

Weakly electric fish employ active electrolocation for orientation and navigation in their environment at night and are thus able to perceive an electrical image of their surroundings even in complete darkness. This principle of active electrolocation is adopted to design a technical sensor system, which will able to detect and to analyze the walls of blood vessels and obstacles within them. The main objective involves the construction and testing of the artificial sensor, including the electronic circuits for signal analysis. To establish effective and optimal parameters for the sensor FEM analysis is done. Simulation results demonstrate the feasibility of proposed design of catheter based electrolocation sensor. Further by implementing efficient design of amplifier and signal processing circuit it is possible to develop biologically inspired technical sensor for routine blood vessel diagnostics and be adopted for finding and analyzing pathologic changes of artery walls.