gebhart/patrepeval huggingface dataset:
Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis (1996)

The aim of this study was to determine the current incidence of side-effects severe enough to cause intolerance of standard antituberculosis therapy with isoniazid, rifampin and pyrazinamide in patients hospitalized as a result of pulmonary tuberculosis. Five hundred and nineteen patients with proven pulmonary tuberculosis, who initially received standard antituberculosis therapy, were retrospectively studied in the department of infectious diseases in a teaching chest hospital. The incidence of severe side-effects related to the therapy, which led to the definitive termination of one of the three standard drugs, was measured and the risk factors for intolerance were analysed. Final termination of either isoniazid, rifampin or pyrazinamide because of severe side-effects was necessary in 121 of the 519 patients (23%). The most severe side-effects leading to final termination of one drug were hepatotoxicity (11%), exanthema (6%), and arthralgia (2%). Pyrazinamide showed more severe side-effects (15%) than isoniazid (7%) and rifampin (1.5%). Significant risk factors for intolerance of the standard therapy following a multivariate analysis were a history of hepatitis (odds ratio (OR) 3.4; 95% confidence interval (95% CI) 1.6-7.6; p = 0.0026) and an age > or = 60 yrs (OR 1.9; 95% CI 1.2-3.2; p = 0.017). Both of these risk factors were also significantly associated with the intolerance of pyrazinamide (history of hepatitis: OR 2.5; 95% CI 1.4-4.3; p = 0.0045; age > or = 60 yrs: OR 2.1, 95% CI 1.3-3.5; p = 0.0029) but not of isoniazid and rifampin. The side-effects of standard antituberculosis therapy are frequent in hospitalized patients aged > or = 60 yrs or with a history of previous hepatitis, and are probably due to pyrazinamide rather than to isoniazid or rifampin.
The B‐Lynch surgical technique for the control of massive postpartum haemorrhage: an alternative to hysterectomy? Five cases reported (1997)

The B-Lynch suturing technique (brace suture) may be particularly useful because of its simplicity of application, life saving potential, relative safety, and its capacity for preserving the uterus and thus fertility. Satisfactory haemostasis can be assessed immediately after application. If it fails, which has not yet been the case, other more radical surgical methods as mentioned in this paper and in the literature can be considered. The special advantage of this innovative technique is an alternative to major surgical procedures to control pelvic arterial pulse pressure or hysterectomy. This suturing technique has been successfully applied with no problems to date and no apparent complications.
Proteomic analysis of the human pathogen <b><i>Trypanosoma cruzi</i></b> (2004)

Abstract Trypanosoma cruzi , the protozoan that causes Chagas disease, possesses a complex life cycle involving different developmental stages. Experimental conditions for two‐dimensional electrophoresis (2‐DE) analysis of T. cruzi trypomastigote, amastigote and epimastigote proteomes were optimized. Comparative proteome analysis of the cell‐cycle stages were carried out, revealing that few proteins included in the 2‐DE maps displayed significant differential expression among the three developmental forms of the parasite. In order to identify landmark proteins, spots from the trypomastigote 2‐DE map were subjected to matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry peptide mass fingerprinting, resulting in 26 identifications that corresponded to 19 different proteins. Among the identified polypeptides, there were heat shock proteins (HSP; chaperones, HSP 60, HSP 70 and HSP 90), elongation factors, glycolytic pathway enzymes (enolase, pyruvate kinase and 2,3 bisphosphoglycerate mutase) and structural proteins (KMP 11, tubulin and paraflagellar rod components). The relative expression of the identified proteins in the 2‐DE maps of the T. cruzi developmental stages is also presented.
Fibrinolytic Therapy in Intraventricular Hemorrhage (2001)

Fibrinolytic therapy with alteplase or u-PA may be life-saving in severe cases of IVH. Yet many technical issues remain to be resolved, such as the optimal dose, frequency, method, timing, and duration of administration of the agent. Additional randomized, double-blind, placebo-controlled studies need to be performed so that the true value of this therapy can be assessed.
Hidden Parameter Markov Decision Processes: An Emerging Paradigm for Modeling Families of Related Tasks. (2014)

The goal of transfer is to use knowledge obtained by solving one task to improve a robot’s (or software agent’s) perfor-mance in future tasks. In general, we do not expect this to work; for transfer to be feasible, there must be something in
Nucleophilic addition and subsequent oxime-assisted ester hydrolysis of diethyl .beta.-ketopropylphosphonate (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleophilic addition and subsequent oxime-assisted ester hydrolysis of diethyl .beta.-ketopropylphosphonatePeter Livant and Michael CociveraCite this: J. Org. Chem. 1978, 43, 15, 3011–3015Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/jo00409a016https://doi.org/10.1021/jo00409a016research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Internet of things for smart ports: Technologies and challenges (2018)

Nowadays, the Internet of Things (IoT) can be considered an important technological revolution related to smart cities, smart homes, smart factories and smart ports implementations. As the presence of smart sensing systems in ports becomes a reality, different operation areas are working today in automatic mode. Examples of challenging projects related to smart ports in the IoT era can be found from Europe to Asia, to Australia, and to North America; in all of these new architecture implementations, sensing technologies play a key role. This paper highlights the main requirements and the key ideas for each ports, sensing solution and also the challenges related to the calibration and testing of distributed sensing systems associated with the main equipment that compose the world largest ports, such as quayside cranes, automated guided vehicles for container handling and yard cranes. Details of the architecture and operations and sensing systems for smart ports are described. Communication standards for smart ports are discussed, and smart ports implementation examples regarding structural health monitoring are considered. Conclusions and future research opportunities in the IoT era are addressed in the final section of the paper.
An Auction Mechanism for Cloud Spot Markets (2016)

Dynamic forms of resource pricing have recently been introduced by cloud providers that offer Infrastructure as a Service (IaaS) capabilities in order to maximize profits and balance resource supply and demand. The design of a mechanism that efficiently prices perishable cloud resources in line with a provider’s profit maximization goal remains an open research challenge, however. In this article, we propose the Online Extended Consensus Revenue Estimate mechanism in the setting of a recurrent, multiunit and single price auction for IaaS cloud resources. The mechanism is envy-free, has a high probability of being truthful, and generates a near optimal profit for the provider. We combine the proposed auction design with a scheme for dynamically calculating reserve prices based on data center Power Usage Effectiveness (PUE) and electricity costs. Our simulation-based evaluation of the mechanism demonstrates its effectiveness under a broad variety of market conditions. In particular, we show how it improves on the classical uniform price auction, and we investigate the value of prior knowledge on the execution time of virtual machines for maximizing profit. We also developed a system prototype and conducted a small-scale experimental study with a group of 10 users that confirms the truthfulness property of the mechanism in a real test environment.
Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection (2015)

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. Therefore, novel therapeutic targets for protecting the heart against acute ischemia/reperfusion injury (IRI) are required to attenuate cardiomyocyte death, preserve myocardial function, and prevent the onset of heart failure. In this regard, a specific group of mitochondrial proteins, which have been linked to familial forms of Parkinson's disease (PD), may provide novel therapeutic targets for cardioprotection. In dopaminergic neurons of the substantia nigra, these PD proteins, which include Parkin, PINK1, DJ-1, LRRK2, and α-synuclein, play essential roles in preventing cell death-through maintaining normal mitochondrial function, protecting against oxidative stress, mediating mitophagy, and preventing apoptosis. These rare familial forms of PD may therefore provide important insights into the pathophysiology underlying mitochondrial dysfunction and the development of PD. Interestingly, these PD proteins are also present in the heart, but their role in myocardial health and disease is not clear. In this article, we review the role of these PD proteins in the heart and explore their potential as novel mitochondrial targets for cardioprotection.
Targeted prostate cancer ablation (2013)

Although none of the advances in cancer detection, targeted imaging or focal treatment have yet proven to be game-changing, together, they have contributed to a movement towards less invasive, focal treatment for prostate cancer and a growing awareness of the potential clinical benefits of this form of therapy.
Use of Short-term Transcriptional Profiles to Assess the Long-term Cancer-Related Safety of Environmental and Industrial Chemicals (2009)

The process for evaluating chemical safety is inefficient, costly, and animal intensive. There is growing consensus that the current process of safety testing needs to be significantly altered to improve efficiency and reduce the number of untested chemicals. In this study, the use of short-term gene expression profiles was evaluated for predicting the increased incidence of mouse lung tumors. Animals were exposed to a total of 26 diverse chemicals with matched vehicle controls over a period of 3 years. Upon completion, significant batch-related effects were observed. Adjustment for batch effects significantly improved the ability to predict increased lung tumor incidence. For the best statistical model, the estimated predictive accuracy under honest fivefold cross-validation was 79.3% with a sensitivity and specificity of 71.4 and 86.3%, respectively. A learning curve analysis demonstrated that gains in model performance reached a plateau at 25 chemicals, indicating that the size of current data set was sufficient to provide a robust classifier. The classification results showed that a small subset of chemicals contributed disproportionately to the misclassification rate. For these chemicals, the misclassification was more closely associated with genotoxicity status than with efficacy in the original bioassay. Statistical models were also used to predict dose-response increases in tumor incidence for methylene chloride and naphthalene. The average posterior probabilities for the top models matched the results from the bioassay for methylene chloride. For naphthalene, the average posterior probabilities for the top models overpredicted the tumor response, but the variability in predictions was significantly higher. The study provides both a set of gene expression biomarkers for predicting chemically induced mouse lung tumors and a broad assessment of important experimental and analysis criteria for developing microarray-based predictors of safety-related end points.
Purification of human albumin by the combination of the method of Cohn with liquid chromatography (1998)

Large volumes of plasma can be fractionated by the method of Cohn at low cost. However, liquid chromatography is superior in terms of the quality of the product obtained. In order to combine the advantages of each method, we developed an integrated method for the production of human albumin and immunoglobulin G (IgG). The cryoprecipitate was first removed from plasma for the production of factor VIII and the supernatant of the cryoprecipitate was fractionated by the method of Cohn. The first precipitate, containing fractions (F)-I + II + III, was used for the production of IgG by the chromatographic method (see Tanaka K et al. (1998) Brazilian Journal of Medical and Biological Research, 31: 1375-1381). The supernatant of F-I + II + III was submitted to a second precipitation and F-IV was obtained and discarded. Albumin was obtained from the supernatant of the precipitate F-IV by liquid chromatography, ion-exchange on DEAE-Sepharose FF, filtration through Sephacryl S-200 HR and introduction of heat treatment for fatty acid precipitation. Viral inactivation was performed by pasteurization at 60 degrees C for 10 h. The albumin product obtained by the proposed procedure was more than 99% pure for the 15 lots of albumin produced, with a mean yield of 25.0 +/- 0.5 g/l plasma, containing 99.0 to 99.3% monomer, 0.7 to 1.0% dimers, and no polymers. Prekallikrein activator levels were < or = 5 IU/ml. This product satisfies the requirements of the 1997 Pharmacopée Européenne.
Resonantly driven CNOT gate for electron spins (2017)

Single-qubit rotations and two-qubit CNOT operations are crucial ingredients for universal quantum computing. Although high-fidelity single-qubit operations have been achieved using the electron spin degree of freedom, realizing a robust CNOT gate has been challenging because of rapid nuclear spin dephasing and charge noise. We demonstrate an efficient resonantly driven CNOT gate for electron spins in silicon. Our platform achieves single-qubit rotations with fidelities greater than 99%, as verified by randomized benchmarking. Gate control of the exchange coupling allows a quantum CNOT gate to be implemented with resonant driving in ~200 nanoseconds. We used the CNOT gate to generate a Bell state with 78% fidelity (corrected for errors in state preparation and measurement). Our quantum dot device architecture enables multi-qubit algorithms in silicon.
Using aggregate human genome data for individual identification (2013)

Data privacy in genome-wide association studies (GWAS) is a critical yet under-exploited research area. In this paper, we first provide a method to construct a two-layered bayesian network explicitly revealing the conditional dependency between SNPs and traits, from the public GWAS catalog. Then we develop efficient algorithms for two attacks: identity inference attack and trait inference attack based on reasoning with the dependency relationship captured in the constructed bayesian network. Different from previously proposed attacks, the possible target of our attacks may be any common people, not limited to GWAS participants. The empirical evaluations show that unprotected statistics released from GWAS can be exploited by attackers to identify individual or derive private information. Thus we show that mining GWAS statistics threatens the privacy of a much wider population and privacy protection mechanisms should be employed.
2‐Pyrrolidone (2011)

Abstract The article contains sections titled: 1. Introduction 2. 2‐Pyrrolidone 3. N ‐Methyl‐2‐pyrrolidone 4. N ‐Vinyl‐2‐pyrrolidone 5. Other Pyrrolidone Derivatives 6. Toxicology and Occupational Health
Reduction of Peptide Character of HIV Protease Inhibitors That Exhibit Nanomolar Potency against Multidrug Resistant HIV-1 Strains (2003)

Novel HIV protease inhibitors containing a hydroxyethylamine dipeptide isostere as a transition state-mimic king structure were synthesized by combining substructures of known HIV protease inhibitors. Among them, TYA5 and TYB5 were proven to be not only potent enzyme inhibitors (K(i) = 0.12 nM and 0.10 nM, respectively) but also strong anti-HIV agents (IC(50) = 9.5 nM and 66 nM, respectively), even against viral strains with multidrug resistance. Furthermore, insertion of an (E)-alkene dipeptide isostere at the P(1)-P(2) position of TYB5 led to development of a purely nonpeptidic protease inhibitor, TYB1 (K(i) = 0.38 nM, IC(50) = 160 nM).
Frameless Localization for Functional Neurosurgical Procedures: A Preliminary Accuracy Study (2004)

Frameless image-guided localization compares favorably to targeting performed noninteractively. In addition, real-time positional feedback confers advantages in target region visualization and confidence in placement of lesions and stimulators for functional procedures. With small improvements in accuracy and system reliability, fully frameless functional procedures could be safely carried out.
Metaheuristic scheduling of multiple picking agents for warehouse management (2008)

Purpose This paper aims to develop a scheduler for multiple picking agents in a warehouse that takes into account distance and loading queue delay minimization within the context of minimizing makespan (i.e. picking time). Design/methodology/approach The paper uses tabu search to solve the scheduling problem in a more global sense. Each search iteration is enhanced by a custom local search (LS) procedure that hastens convergence by driving a given schedule configuration quickly to a local minimum. In particular, basic operators transfer demand among agents to balance load and minimize makespan. The new load distribution is further improved by considering a vehicle‐routing problem on the picking assignments of the agents with relocated demands. Loading queue delays that may arise from the reassignments are systematically minimized using a fast scheduling heuristic. Findings The proposed tabu scheduler greatly improves over a widely practiced scheduling procedure for the given problem. Variants of the tabu scheduler produce solutions that are roughly of the same quality but exhibit considerable differences in computational time. Research limitations/implications The proposed methodology is applicable only to the static scheduling problem where all inputs are known beforehand. Furthermore, of the possible delays during picking, only loading queues are explicitly addressed (although this is justifiable, given that these delays are dominant in the problem). Practical implications The proposed approach can significantly increase through‐put and productivity in picking systems that utilize multiple intelligent agents (human pickers included), e.g. in warehouses/distribution centers. Originality/value The paper addresses a practical scheduling problem with a high degree of complexity, i.e. scheduler explicitly deals with delays while trying to minimize makespan (generally, delays are ignored in the literature to simplify things). In the tabu implementation, an LS procedure is introduced in the metaheuristic loop that enhances the search process by minimizing non‐productive time of picking agents (travel time and delays).
How to Conduct Store Observations of Tobacco Marketing and Products (2016)

As tobacco companies continue to heavily market their products at the point of sale, tobacco control groups seek strategies to combat the negative effects of this marketing. Store observations, which have been widely used by researchers and practitioners alike, are an excellent surveillance tool. This article provides a guide for public health practitioners interested in working in the tobacco retail environment by detailing the steps involved in conducting store observations of tobacco marketing and products including 1) obtaining tobacco product retailer lists, 2) creating measures, 3) selecting a mode of data collection, 4) training data collectors, and 5) analyzing data. We also highlight issues that may arise while in the field and provide information on disseminating results of store observations, including the potential policy implications.
Mathematical modeling of normal pharyngeal bolus transport: a preliminary study. (1998)

Dysphagia (difficulty in swallowing) is a common clinical symptom associated with many diseases, such as stroke, multiple sclerosis, neuromuscular diseases, and cancer. Its complications include choking, aspiration, malnutrition, cachexia, and dehydration. The goal in dysphagia management is to provide adequate nutrition and hydration while minimizing the risk of choking and aspiration. It is important to advance the individual toward oral feeding in a timely manner to enhance the recovery of swallowing function and preserve the quality of life. Current clinical assessments of dysphagia are limited in providing adequate guidelines for oral feeding. Mathematical modeling of the fluid dynamics of pharyngeal bolus transport provides a unique opportunity for studying the physiology and pathophysiology of swallowing. Finite element analysis (FEA) is a special case of computational fluid dynamics (CFD). In CFD, the flow of a fluid in a space is modeled by covering the space with a grid and predicting how the fluid moves from grid point to grid point. FEA is capable of solving problems with complex geometries and free surfaces. A preliminary pharyngeal model has been constructed using FEA. This model incorporates literature-reported, normal, anatomical data with time-dependent pharyngeal/upper esophageal sphincter (UES) wall motion obtained from videofluorography (VFG). This time-dependent wall motion can be implemented as a moving boundary condition in the model. Clinical kinematic data can be digitized from VFG studies to construct and test the mathematical model. The preliminary model demonstrates the feasibility of modeling pharyngeal bolus transport, which, to our knowledge, has not been attempted before. This model also addresses the need and the potential for CFD in understanding the physiology and pathophysiology of the pharyngeal phase of swallowing. Improvements of the model are underway. Combining the model with individualized clinical data should potentially improve the management of dysphagia.