gebhart/patrepeval huggingface dataset:
All Solid-State Instrument for Absorbance Based Optical Gas Sensor Membranes (1997)

Abstract The compact instrument is based on a light-emitting diode as radiation source and a photodiode as detector. A fiber optic cable is used for guiding the light to and from the membrane located at the tip. In contrast to earlier designs, the small sensor head is freely accessible to ambient atmospheres. The resulting effect of background light is removed by lock-in amplification using a single integrated circuit synchronous demodulator. Ratioing against a reference signal is carried out in order to eliminate instabilities of light-emitting diodes caused by temperature fluctuations or ageing. The system is demonstrated with membranes for the sensing of ammonia and carbon dioxide in the vapour phase.
Hsp70-2 is Required for Tumor Cell Growth and Survival (2005)

Heat shock protein 70 (Hsp70) family consists of at least eight chaperone proteins that differ from each other by their pattern of expression and intracellular localization. Whereas ample experimental and clinicopathological data has implicated the major stress-inducible Hsp70-1 as a protein required for cancer cell survival, the study of the other family members has been limited by the lack of experimental tools to differentiate between the highly homologous family members. This limitation has been recently overcome by the RNA interference technology that for the first time allows targeted knockdown of the individual Hsp70 family members. Data based on this technology has revealed that also Hsp70-2, a protein essential for spermatogenesis, is required for cancer cell growth and survival. Remarkably, the highly homologous Hsp70 proteins enhance cancer cell growth and survival by distinct molecular mechanisms.
[2+1] Cycloaddition of Nitrene onto C<sub>60</sub> Revisited: Interconversion between an Aziridinofullerene and an Azafulleroid (2008)

An open and closed case: The reversible interconversion of a [1,2]aziridinofullerene and a [1,6]azafulleroid represents the first such example for a monosubstituted fullerene. While the [1,2]aziridinofullerene rearranges thermally to the [1,6]azafulleroid, the [1,6]azafulleroid rearranges photochemically to the [1,2]aziridinofullerene in high yield (see picture). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704410_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Protecting Privacy in Trajectories with a User-Centric Approach (2018)

The increased use of location-aware devices, such as smartphones, generates a large amount of trajectory data. These data can be useful in several domains, like marketing, path modeling, localization of an epidemic focus, and so on. Nevertheless, since trajectory information contains personal mobility data, improper use or publication of trajectory data can threaten users’ privacy. It may reveal sensitive details like habits of behavior, religious beliefs, and sexual preferences. Therefore, many users might be unwilling to share their trajectory data without a previous anonymization process. Currently, several proposals to address this problem can be found in the literature. These solutions focus on anonymizing data before its publication, i.e., when they are already stored in the server database. Nevertheless, we argue that this approach gives the user no control about the information she shares. For this reason, we propose anonymizing data in the users’ mobile devices, before they are sent to a third party. This article extends our previous work which was, to the best of our knowledge, the first one to anonymize data at the client side, allowing users to select the amount and accuracy of shared data. In this article, we describe an improved version of the protocol, and we include the implementation together with an analysis of the results obtained after the simulation with real trajectory data.
Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration (2018)

Our data implicate subretinal macrophages, C1q and the classical pathway in progressive retinal degeneration. We demonstrate a role of local C1q produced by microglia/macrophages as an instigator of inflammasome activation and inflammation. Crucially, we have shown that retinal C1q neutralisation during disease progression may slow retinal atrophy, providing a novel strategy for the treatment of complement-mediated retinal degenerations including AMD.
Mechanical Doppler compensation for electron excitation of NRF photons (2008)

Identification of Special Nuclear Material (SNM) by Nuclear Resonance Fluorescence is developing as a promising method but is currently limited by available photon sources. A very limited source spectrum (≪ 1 eV width at MeV energies) is ideal. One method of providing this source is by electron excitation of a target containing the nucleus of interest. In this method, however, the photon energy mismatch caused by the nuclear recoil must be accounted for. We propose to provide this Doppler compensation by directing an MeV-range electron beam at a rotating target loaded with the nucleus of interest. Rotation rates are in excess of 200,000 RPM for the NRF lines of interest in SNM detection. Some design scenarios will be discussed, along with issues pertaining to nuclear physics and materials science.
Receiving, decoding and noise limiting systems for a new pressure-sensitive ingestible radio telemetric capsule (1983)

A new pressure-sensitive radiotelemetric capsule for recording intraluminal pressures within the human gastrointestinal tract has been developed; this capsule employs a pulsed mode of operation. Data recording as a pulse train greatly simplifies problems encountered hitherto in this field, but has produced the requirement for a decoding system which, on tape replay, will reproduce the original pressure change. A system is described here which, in addition to producing an analogue signal from the recorded pulse train, will also eliminate artefacts due to either spurious radio signals or variations in magnetic tape transport speed; it also provides a sensitive and accurate indication of transient signal loss.
Interleukin-1 receptor antagonist in inflammatory exudate cells of rabbits. Production, purification and determination of primary structure. (1992)

A rabbit interleukin-1 (IL-1) inhibitor in inflammatory peritoneal exudate cells was purified to apparent homogeneity. This inhibitor was extracted from exudate cells of the 24-hr stage of casein-induced peritoneal inflammation and purified using isoelectrofocusing (IEF), gel filtration, followed in this order by high-performance liquid chromatography (HPLC) steps with hydroxylapatite and anionic ion exchanger. The purified factor showed a single band on silver-stained SDS-PAGE. This molecule of MW 19,000 and pI 5.5 inhibited the binding of both IL-1 alpha and beta to receptors on a thymoma cell line, EL-4 and a B-cell line, 70Z/3. We determined its primary structure by a combination of peptide chemistry and molecular cloning. The inhibitor was synthesized as a precursor composed of 177 amino acids and was processed to a mature molecule of 143 amino acids. The N-terminal amino acid of the mature inhibitor was N-acetyl-methionine residue. The deduced amino acid sequence of the inhibitor showed a 77% homology to the human IL-1 receptor antagonist (IL-1Ra) and essentially the same mode of action as seen with human IL-1Ra. We consider that this inhibitor is a rabbit counterpart of human IL-1Ra, although there are differences with respect to the molecular structure; the N-terminus of the mature rabbit IL-1Ra at a position of nine amino acids downstream from that of human IL-1Ra.
COMPOSITION OF “POLYPHOSPHORIC ACID TRIMETHYLSILYL ESTER (PPSE)” AND ITS USE AS A CONDENSATION REAGENT (1982)

Abstract Phosphorus pentoxide reacts readily with anhydrous hexamethyldisiloxane (HMDSO) to form mixtures of tetraphosphoric acid trimethylsilyl esters (so-called PPSE), the composition of which being estimated from 31P NMR data. PPSE was conveniently used as a condensation reagent for the syntheses of benzimidazoles, indoles, and isoquinoline derivatives. Heterogenized PPSE by using silica gel instead of HMDSO was found to be equally useful.
An Immunoenzyme Procedure for Enumerating Fibronectin-Secreting Cells (1984)

A recently described solid phase immunoenzyme procedure (ELISPOT) has been adapted for the detection of individual cells secreting fibronectin. Simple and sensitive, this technique should find useful application for studying fibronectin production at the cellular level.
Electrical Properties of Biopolymers and Membranes (1989)

Origin of dipole moment polarization of groups of polar molecules dynamic aspect of electrical polarization dielectric properties of polymer molecules dielectric properties of proteins, peptides and amino acids theory of interfacial polarization dielectric properties of nucleic acids water in biological systems non-linear dielectric properties electrical properties of biological membranes.
Oxidation of primary and secondary benzylic alcohols with hydrogen peroxide and tert-butyl hydroperoxide catalyzed by a “helmet” phthalocyaninato iron complex in the absence of added organic solvent (2014)

The oxidation of four benzylic alcohols employing hydrogen peroxide and TBHP as oxidants, catalyzed by an iron(III) complex bearing a 14,28-[1,3-diiminoisoindolinato]phthalocyaninato (diiPc) ligand has been studied and found to proceed with good selectivity, high turnover numbers, and high turnover frequencies in the absence of organic solvents other than the substrates themselves.
Design and Running of a Surveying Ship for Bathymetry of The Manned and Unmanned Control System (2011)

지상 또는 해상에서 주로 이루어지고 있는 수심측량은 측량선을 타고 사람이 직접 측량하거나 측량선을 이용하여 목표지점을 측정하는 방법 등이 주로 이용된다. 그러나 현재 이용되는 측량선은 유인과 무인시스템으로 나누어져 있어 수심의 상태 또는 기상상태에 따라 능동적인 대처가 어려웠다. 따라서 본 연구에서는 악천후나 광활한 지역과 같이 접근성이 어려운 곳은 무인 원격제어를 이용하여 수심 측정이 가능한 측량선을 구현하고자 한다. 본 연구에서 개발된 유 무인 측량선의 제어시스템은 무선통신을 이용하여 사용자에 의해 미리 설정한 경로대로 움직이는 자동제어방식과 제어국에서 직접 측량선의 방향과 속도 등을 제어 할 수 있는 최적화 된 수동제어방식의 측량이 가능하게 하였다. Bathymetry which is mainly used on the earth or the sea can be surveyed directly by a person who is on a surveying ship or in a way one estimates the target through a surveying ship. However, the surveying ship which is being used now is divided into a manned and unmanned system and it's difficult to deal with it appropriately according to the water depth or the condition of weather. Therefore, this study will invent the surveying ship that can measure the water depth with the unmanned remote control system in the place where it's difficult to for man access because of a bad weather or a vast area. There are two methods in the control system of the manned and unmanned surveying ship which has been developed in this study. One is an automatic control which moves on the path set by the user in advance and the other is the optimized passive control in which the control station can manage the direction and speed of a surveying ship directly.
Resource allocation for non-real-time services in OFDM-based cognitive radio systems (2009)

We study the resource allocation (RA) problem in a multiuser OFDM-based cognitive radio (CR) system for non-realtime (NRT) applications in which average user data rates are to be maintained proportionally. In contrast to existing algorithms designed for multiuser OFDM systems, which are unable to guarantee users proportional rates when applied in a CR system, the proposed optimal RA algorithm ensures that CR user rates are maintained in proportion to predefined target rates while at the same time providing an improved system throughput.
Ligand basicity and rigidity control formation of macrocyclic polyamino carboxylate complexes of gadolinium(III) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLigand basicity and rigidity control formation of macrocyclic polyamino carboxylate complexes of gadolinium(III)Krishan Kumar and M. F. TweedleCite this: Inorg. Chem. 1993, 32, 20, 4193–4199Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://doi.org/10.1021/ic00072a008Request reuse permissionsArticle Views515Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (797 KB) Get e-Alertsclose Get e-Alerts
Comprehensive Discharge Planning for the Hospitalized Elderly (1994)

Study findings support the need for comprehensive discharge planning designed for the elderly and implemented by nurse specialists to improve their outcomes after hospital discharge and to achieve cost savings. The findings also suggest that this intervention had its greatest effect in delaying or preventing rehospitalization of patients in the medical intervention group during the first 6 weeks after discharge.
Session-based watermarking in live IPTV environment (2012)

Protecting content, distributed over IPTV networks, from being illegally redistributed by legal subscribers requires methods beyond traditional conditional access and digital rights management systems. Adding watermarking techniques allows one to trace the user would an infringement have occurred. In this paper we describe a practical way to uniquely watermark content for each receiving device in a live IPTV environment. Special focus is given to finding a solution that fits into existing IPTV infrastructures.
The 7[prime]-Methyl Group of Abscisic Acid Is Critical for Biological Activity in Wheat Embryo Germination (1994)

Wheat (Triticum aestivum L.) embryo germination is inhibited by natural (S)-(+)-abscisic acid (ABA). In this report we have determined critical structural features of the ABA molecule, particularly the methyl and ketone groups of the ABA ring, required for inhibitory activity. To examine the ring residues a series of new optically active ABA analogs have been synthesized in which the 4[prime]-keto, 7[prime]-, 8[prime]-, or 8[prime]- and 9[prime]-carbons have been replaced with hydrogen atoms. Each of the analogs was tested over a range of concentrations as a germination inhibitor. Enantiomers of the analogs altered at the 4[prime]-keto or 8[prime]- and 9[prime]-methyl groups were active, but less so than ABA. Both enantiomers of 7[prime]-demethylABA were inactive as germination inhibitors. The results show that the 7[prime]-methyl group is absolutely required for activity, but that the other residues are less critical for hormone recognition.
Development of models for cytochrome P450 2A5 as well as two of its mutants. (2005)

It is known that small changes in the amino acid sequence can change the catalytic activity of cytochromes towards substrates dramatically. With the aim to broaden our knowledge about the structural properties of cytochromes and their relation with substrate specificity a model of CYP2A5 was built by homology modelling based on the crystal structure of CYP2C5. Model stability was evaluated by subjection of the model to a free molecular dynamics simulation in a waterbox under almost physiological conditions using the GROMACS program. The protein folding remains stable over 1.5 ns under these conditions. The modelling procedure was repeated for two mutated forms of CYP2A5 with known differing substrate selectivities towards corticosterone and desoxycorticosterone. A detailed analysis of the models and their behaviour in long running molecular dynamics simulations allows an understanding of the requirements for enzyme activity as well as an explanation of respective experimental data on the molecular level.
Deaths: leading causes for 2010. (2013)

In 2010, the 10 leading causes of death were, in rank order: Diseases of heart; Malignant neoplasms; Chronic lower respiratory diseases; Cerebrovascular diseases; Accidents (unintentional injuries); Alzheimer's disease; Diabetes mellitus; Nephritis, nephrotic syndrome and nephrosis; Influenza and pneumonia; and Intentional self-harm (suicide). These 10 causes accounted for 75% of all deaths occurring in the United States. Differences in the rankings are evident by age, sex, race, and Hispanic origin. Leading causes of infant death for 2010 were, in rank order: Congenital malformations, deformations and chromosomal abnormalities; Disorders related to short gestation and low birth weight, not elsewhere classified; Sudden infant death syndrome; Newborn affected by maternal complications of pregnancy; Accidents (unintentional injuries); Newborn affected by complications of placenta, cord and membranes; Bacterial sepsis of newborn; Respiratory distress of newborn; Diseases of the circulatory system; and Necrotizing enterocolitis of newborn. Important variations in the leading causes of infant death are noted for the neonatal and post-neonatal periods.
Global Infectious Diseases and Epidemiology Network (GIDEON): A World Wide Web-Based Program for Diagnosis and Informatics in Infectious Diseases (2004)

The Global Infectious Diseases and Epidemiology Network (GIDEON) (http://www.gideononline.com) consists of 4 modules. The first is designed to generate a ranked differential diagnosis list for any infectious diseases scenario in any of 220 countries. The second follows the country-specific epidemiology of 337 individual diseases. The third presents a comprehensive encyclopedia of 308 generic anti-infective drugs and vaccines, including a listing of >9500 trade names. The fourth generates a ranked identification list based on the phenotype of bacteria, mycobacteria, and yeasts. The program performs well and serves as a useful paradigm for World Wide Web—based informatics. GIDEON is an eclectic program that can serve the needs of clinicians, epidemiologists, and microbiologists working in the fields of infectious diseases and geographic medicine.
Beta 2 Toxigenic <i>Clostridium Perfringens</i> Type A Colitis in a Three-Day-Old Foal (2011)

Beta 2 (β2)-toxigenic Clostridium perfringens type A was recovered in large numbers from the intestine of a neonatal foal with colitis. The foal had been treated with gentamicin. Necropsy revealed marked distension of cecum and colon with watery, rust-colored homogeneous fluid and gastric infarction. Microscopic colonic lesions were superficial necrosis of 50% of the colonic mucosal surface and scattered 1-3-mm ulcers with subjacent neutrophilic infiltration and large Gram-positive bacilli in the necrotic mucosa. Beta-2 toxin was demonstrated in the lesions by immunohistochemical staining.
Acylation-stimulating protein (ASP): structure–function determinants of cell surface binding and triacylglycerol synthetic activity (1999)

Acylation-stimulating protein (ASP or C3adesArg) is a potent lipogenic factor in human and murine adipocytes and fibroblasts. The arginated form of ASP, i.e. complement C3a (C3a), stimulates immunological responses in human granulocytes, mast cells, guinea pig platelets and guinea pig macrophages; however, ASP is inactive in stimulating these responses. Thus both ASP and C3a are bioactive across species but are not functionally interchangeable. Tertiary structure of both proteins by X-ray crystallography and NMR spectroscopy predicts a tightly linked core region consisting of three alpha-helices linked via three disulphide bonds, with one of the alpha-helices extending out from the core and terminating in a flexible conformationally irregular carboxy-tail region. The present studies were undertaken in order to define the functionally active domains of ASP, distinctive from those of C3a, using chemical modifications, enzymic cleavage and synthetic peptide fragments. The results indicate that: (i) the N-terminal region (<10 amino acids) plays little role in ASP receptor binding and triacylglycerol synthesis stimulation; (ii) the native C-terminal region had no activity, but modifications which increased hydrophobicity increased receptor binding, and led to some activation of triacylglycerol synthesis stimulation; (iii) an intact disulphide-linked core region is essential for triacylglycerol synthesis stimulation activity but not for receptor interaction. Finally, basic charges in the carboxy region (His) are essential for ASP triacylglycerol synthesis stimulation but not for receptor binding, whereas both functions are eliminated by the modification of Lys in the disulphide-linked core region. The present results suggest that there are two functional domains in ASP, one that is responsible for the initial binding to the cell surface receptor, and a second domain that activates and increases triacylglycerol synthesis stimulation. This contrasts markedly with the structure-function studies of C3a where both binding competency and function were dependent on the C-terminal Arg. Thus ASP demonstrates distinct bioactivity.
Development of amplified consensus genetic markers (ACGM) in<i>Brassica napus</i>from<i>Arabidopsis thaliana</i>sequences of known biological function (1999)

A method for the development of consensus genetic markers between species of the same taxonomic family is described in this paper. It is based on the conservation of the peptide sequences and on the potential polymorphism within non-coding sequences. Six loci sequenced from Arabidopsis thaliana, AG, LFY3, AP3, FAD7, FAD3, and ADH, were analysed for one ecotype of A. thaliana, four lines of Brassica napus, and one line for each parental species, Brassica oleracea and Brassica rapa. Positive amplifications with the degenerate primers showed one band for A. thaliana, two to four bands in rapeseed, and one to two bands in the parental species. Direct sequencing of the PCR products confirms their peptide similarity with the "mother" sequence. By comparison of intron sequences, the correspondence between each rapeseed gene and its homologue in one of the parental species can be determined without ambiguity. Another important result is the presence of a polymorphism inside these fragments between the rapeseed lines. This variability could generally be detected by differences of electrophoretic migration on long non-denaturing polyacrylamide gels. This method enables a quick and easy shuttle between A. thaliana and Brassica species without cloning.