gebhart/patrepeval huggingface dataset:
Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing (2017)

Fibroblasts are primary cellular protagonists of wound healing. They also exhibit circadian timekeeping, which imparts an approximately 24-hour rhythm to their biological function. We interrogated the functional consequences of the cell-autonomous clockwork in fibroblasts using a proteome-wide screen for rhythmically expressed proteins. We observed temporal coordination of actin regulators that drives cell-intrinsic rhythms in actin dynamics. In consequence, the cellular clock modulates the efficiency of actin-dependent processes such as cell migration and adhesion, which ultimately affect the efficacy of wound healing. Accordingly, skin wounds incurred during a mouse's active phase exhibited increased fibroblast invasion in vivo and ex vivo, as well as in cultured fibroblasts and keratinocytes. Our experimental results correlate with the observation that the time of injury significantly affects healing after burns in humans, with daytime wounds healing ~60% faster than nighttime wounds. We suggest that circadian regulation of the cytoskeleton influences wound-healing efficacy from the cellular to the organismal scale.
C-102 Zika virus (2017)

JAIDS: Journal of Acquired Immune Deficiency Syndromes​ seeks to end the HIV epidemic by presenting important new science across all disciplines that advance our understanding of the biology, treatment and prevention of HIV infection worldwide. JAIDS: Journal of Acquired Immune Deficiency Syndromes is the trusted, interdisciplinary resource for HIV- and AIDS-related information with a strong focus on basic and translational science, clinical science, and epidemiology and prevention. Co-edited by the foremost leaders in clinical virology, molecular biology, and epidemiology, JAIDS publishes vital information on the advances in diagnosis and treatment of HIV infections, as well as the latest research in the development of therapeutics and vaccine approaches. This ground-breaking journal brings together rigorously peer-reviewed articles, reviews of current research, results of clinical trials, and epidemiologic reports from around the world.
AFC-Enabled Vertical Tail System Integration Study (2014)

This document serves as the final report for the SMAAART AFC-Enabled Vertical Tail System Integration Study. Included are the ground rule assumptions which have gone into the study, layouts of the baseline and AFC-enabled configurations, critical sizing information, system requirements and architectures, and assumed system properties that result in an NPV assessment of the two candidate AFC technologies.
Chemistry of phosphorous acid: new routes to phosphonic acids and phosphate esters (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of phosphorous acid: new routes to phosphonic acids and phosphate estersDerek RedmoreCite this: J. Org. Chem. 1978, 43, 5, 992–996Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://pubs.acs.org/doi/10.1021/jo00399a041https://doi.org/10.1021/jo00399a041research-articleACS PublicationsRequest reuse permissionsArticle Views1282Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Natural occurrence of beauvericin in preharvest Fusarium subglutinans infected corn ears in Poland (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNatural occurrence of beauvericin in preharvest Fusarium subglutinans infected corn ears in PolandAntonio. Logrieco, Antonio. Moretti, Alberto. Ritieni, Jerzy. Chelkowski, Claudio. Altomare, Antonio. Bottalico, and Giacomino. RandazzoCite this: J. Agric. Food Chem. 1993, 41, 11, 2149–2152Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/jf00035a061https://doi.org/10.1021/jf00035a061research-articleACS PublicationsRequest reuse permissionsArticle Views245Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Use of non-geostationary orbits for a Ka-band Personal Access Satellite system (1990)

This paper discusses the use of satellites in circular orbits at altitudes high enough for continental U.S. (CONUS) visibility. This enables one satellite to relay signals between geographically separated earth stations within CONUS at any one time and thus bypasses the need for intersatellite links. System performance is examined for three circular satellite orbits at altitudes of 20,182 km, 10,353 km, and 5143 km. Inclination angles between the satellite orbit plane and the equatorial plane of 0, 45, and 90 deg are considered. The number of satellites required to provide continuous CONUS coverage is calculated.
Enzymatic allylic oxidations with a lyophilisate of the edible fungus Pleurotus sapidus (2012)

Allylic oxidations belong to the most attractive synthetic transformations because they convert readily available and cheap starting materials into value-added products. In this study, we describe oxidative conversions of terpenoids and a number of related cycloalkenes with a lyophilisate of the edible fungus Pleurotus sapidus. The biocatalytic protocol is simple and the biocatalyst is readily available. The conversions of various cycloalkenes proceed cleanly in most cases to the corresponding enones. The substrate scope is remarkable and includes a number of mono- and sequiterpenes, functionalized terpenoids as well as simple cyclohexenes and benzylic substrates. Enzymatic allylic oxidations by Pleurotus sapidus are thus an excellent non-toxic alternative to metal-mediated oxidation procedures in academic labs and for industrial application in food technology, cosmetics or pharmaceutical research.
Phase I and Correlative Biology Study of Cilengitide in Patients With Recurrent Malignant Glioma (2007)

Cilengitide is well tolerated to doses of 2,400 mg/m2, durable complete and partial responses were seen in this phase I study, and clinical response appears related to rCBF changes.
Magnesium-Isotope Fractionation During Plant Growth (2008)

Magnesium is an essential nutrient, which activates more enzymes than any other mineral element and, thus, plays an important role in biogeochemical cycles. With three stable isotopes naturally abundant (24Mg, 78.992%; 25Mg, 10.003%; 26Mg, 11.005%), magnesium stable isotope fractionation may provide insights into these cycles. Here, we detail for the first time the magnesium stable-isotope distribution in a higher plant, wheat (Triticum aestivum L.), during its growth cycle. Wheat plants were grown in a limiting nutrient supply hydroponically, some being left to mature through senescence and others detopped at maturity for collection of exudates. Measurements of the magnesium isotopic composition of chlorophylls, seeds, shoots, roots, leaves, exudates, and the limiting nutrient solution over time show that the plant appears to establish an isotopic equilibrium with the nutrient available to it and that the plant (in particular, the seeds and exudates) becomes enriched in the heavy isotopes of magnesium in a mass-dependent relationship as the plant reaches maturity. The preference of the plants for heavy magnesium isotopes suggests that a difference might exist in the bioavailable magnesium of agricultural and natural soils due to the periodic removal of heavy magnesium isotopes by harvest.
International prognostic indices in diffuse large B-cell lymphoma: a comparison of IPI, R-IPI, and NCCN-IPI (2020)

Great heterogeneity in survival exists for patients newly diagnosed with diffuse large B-cell lymphoma (DLBCL). Three scoring systems incorporating simple clinical parameters (age, lactate dehydrogenase, number/sites of involvement, stage, performance status) are widely used: the International Prognostic Index (IPI), revised IPI (R-IPI), and National Comprehensive Cancer Network IPI (NCCN-IPI). We evaluated 2124 DLBCL patients treated from 1998 to 2009 with frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP; or variant) across 7 multicenter randomized clinical trials to determine which scoring system best discriminates overall survival (OS). Median age was 63 years, and 56% of patients were male. Five-year OS estimates ranged from 54% to 88%, from 61% to 93%, and from 49% to 92% using the IPI, R-IPI, and NCCN-IPI, respectively. The NCCN-IPI had the greatest absolute difference in OS estimates between the highest- and lowest-risk groups and best discriminated OS (concordance index = 0.632 vs 0.626 [IPI] vs 0.590 [R-IPI]). For each given IPI risk category, NCCN-IPI risk categories were significantly associated with OS (P ≤ .01); the reverse was not true, and the IPI did not provide additional significant prognostic information within all NCCN-IPI risk categories. Collectively, the NCCN-IPI outperformed the IPI and R-IPI. Patients with low-risk NCCN-IPI had favorable survival outcomes with little room for further improvement. In the rituximab era, none of the clinical risk scores identified a patient subgroup with long-term survival clearly <50%. Integrating molecular features of the tumor and microenvironment into the NCCN-IPI or IPI might better characterize a high-risk group for which novel treatment approaches are most needed.
Sensors and Signal Transduction in the Activation of Cell Volume Regulatory Ion Transport Systems (1998)

Research Articles| August 05 2010 Über eine bewegliche Mutante des B. anthracis Subject Area: Further Areas , Oncology , Pathology and Cell Biology J. Tomcsik J. Tomcsik (Aus dem Hygiene-Inslitut der Universität Basel) Search for other works by this author on: This Site PubMed Google Scholar Schweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie (1950) 13 (5): 616–624. https://doi.org/10.1159/000159921 Article history Published Online: August 05 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. Tomcsik; Über eine bewegliche Mutante des B. anthracis. Schweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie 1 May 1950; 13 (5): 616–624. https://doi.org/10.1159/000159921 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSchweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie Search Advanced Search Article PDF first page preview Close Modal 1950Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
The Arterial Wall and Atherosclerosis (1979)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Car Pooling Based on Trajectories of Drivers and Requirements of Passengers (2017)

Car pooling is a collective transportation model based on shared use of private cars. The objective of car pooling is to reduce the number of cars in use by grouping people. By exploiting car pooling model, it can significantly reduce congestion, fuel consumption, air pollution, parking demands and commuting costs. This paper aims to develop a prototype car pooling system to match passengers and drivers based on their trajectories. We propose a heuristic method to solve the car pooling problem. In our approach, we collect the trajectory data of passengers and drivers first. We then propose a matching algorithm to assign passengers to drivers' cars based on their trajectories. The car pooling system proposed in this study combines a matching algorithm that is seamlessly integrated with Google Maps API, dynamic web pages and database system. We also conduct experiments to illustrate our proposed method.
Roles and mechanisms of leptin in osteogenic stimulation in cervical ossification of the posterior longitudinal ligament (2018)

From this research, we got that leptin treatment led to a significant increase in mRNA expressions of ALP and OCN and formation of mineralized nodule. And the osteogenic effect of leptin in C-OPLL cells could be mediated via ERK1/2, p38 MAPK, and/or JNK signaling pathways.
Symbol error probabilities for general cooperative links (2004)

Cooperative diversity (CD) networks have been receiving a lot of attention recently as a distributed means of improving error performance and capacity. This paper derives the average symbol error probability (SEP) for amplify and forward CD links. The resulting expressions are general as they hold for an arbitrary number of cooperating branches, arbitrary number of cooperating hops per branch, and many channel fading models. Their simplicity provides valuable insights to the performance of CD networks and allows their optimization. Besides revealing the diversity advantage, they clearly show from where this advantage comes from and prove that the diversity advantage holds independently of the channel fading model. Finally, explain how diversity is improved in multihop CD networks.
Synthesis of anthopleurine, the alarm pheromone from Anthopleura elegantissima (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of anthopleurine, the alarm pheromone from Anthopleura elegantissimaJames A. Musich and Henry RapoportCite this: J. Am. Chem. Soc. 1978, 100, 15, 4865–4872Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ja00483a037https://doi.org/10.1021/ja00483a037research-articleACS PublicationsRequest reuse permissionsArticle Views1055Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enabling autonomic workload management in Linux (2004)

Complexity reduction in workload management is driving the development of goal-oriented workload managers (WLMs). Simultaneously, server consolidation of workloads with dynamically changing resource demands calls for these WLMs to be increasingly efficient in managing resources. We propose the class-based kernel resource management (CKRM) framework, implemented in Linux, for operating systems to these requirements.
Fourier multiaperture emission tomography (FMET). (1979)

We describe a new emission tomographic technique, using an Anger scintillation camera and a new family of coded apertures, in which a noniterative computer algorithm is used to reconstruct multiplanar images. The novel feature is a set of spatial narrow band filters that allow the depth information to be separated in the frequency domain. The position of the reconstructed planes can be selected at will. Using this technique, a planar resolution of 0.75 cm and a depth resolution of 1.6 cm have been measured at a depth of 10 cm and a magnification of 1. To demonstrate the potential of this system, the results of a phantom study are reported.
Automated Identification of Northern Leaf Blight-Infected Maize Plants from Field Imagery Using Deep Learning (2017)

Northern leaf blight (NLB) can cause severe yield loss in maize; however, scouting large areas to accurately diagnose the disease is time consuming and difficult. We demonstrate a system capable of automatically identifying NLB lesions in field-acquired images of maize plants with high reliability. This approach uses a computational pipeline of convolutional neural networks (CNNs) that addresses the challenges of limited data and the myriad irregularities that appear in images of field-grown plants. Several CNNs were trained to classify small regions of images as containing NLB lesions or not; their predictions were combined into separate heat maps, then fed into a final CNN trained to classify the entire image as containing diseased plants or not. The system achieved 96.7% accuracy on test set images not used in training. We suggest that such systems mounted on aerial- or ground-based vehicles can help in automated high-throughput plant phenotyping, precision breeding for disease resistance, and reduced pesticide use through targeted application across a variety of plant and disease categories.
The Demand and Supply of Criminal Opportunities (1986)

Criminal opportunity theory provides a framework for examining the interaction between potential offenders and potential victims. Criminals' behavior influences the nature and amount of self-protective measures taken by potential victims, and changes in self-protection make criminal opportunities more or less attractive. Criminal opportunity theory has precursors in criminological theory, preeminently in the work of Cloward and Ohlin, but in these theories opportunities are mediated through social learning. Criminal opportunity theory employs the economic theory of markets to describe and predict how criminals and victims interact. Evidence is available that potential victims take more self-protection measures when the perceived risk of victimization is greater and that prospective criminals are likelier to attack relatively more vulnerable targets. Little research is available on whether increases in self-protection reduce the total volume of crime or merely displace crime to more vulnerable targets; the extent of displacement probably differs among offenses. The market perspective has several benefits to the investigation of interaction between potential victims and offenders: it assembles different topics encompassed by criminal opportunity theory into a coherent whole, it is expressed in a form that facilitates borrowing from economic theory, and it generates new and important insights for policy evaluation and criminological theory. One central insight is that law enforcement strategies may alter the quality of opportunities and thereby precipitate additional crime. Effective incapacitation or rehabilitation policies, for example, may reduce the number of offenders in circulation and thereby reduce the perceived risk of victimization. This may cause individuals to reduce their self-protection efforts, making them more attractive targets than before and thereby stimulating increased crime rates on the part of those criminals who remain active.