gebhart/patrepeval huggingface dataset:
Delayed Stabilization of Dendritic Spines in Fragile X Mice (2010)

Fragile X syndrome (FXS) causes mental impairment and autism through transcriptional silencing of the Fmr1 gene, resulting in the loss of the RNA-binding protein fragile X mental retardation protein (FMRP). Cortical pyramidal neurons in affected individuals and Fmr1 knock-out (KO) mice have an increased density of dendritic spines. The mutant mice also show defects in synaptic and experience-dependent circuit plasticity, which are known to be mediated in part by dendritic spine dynamics. We used in vivo time-lapse imaging with two-photon microscopy through cranial windows in male and female neonatal mice to test the hypothesis that dynamics of dendritic protrusions are altered in KO mice during early postnatal development. We find that layer 2/3 neurons from wild-type mice exhibit a rapid decrease in dendritic spine dynamics during the first 2 postnatal weeks, as immature filopodia are replaced by mushroom spines. In contrast, KO mice show a developmental delay in the downregulation of spine turnover and in the transition from immature to mature spine subtypes. Blockade of metabotropic glutamate receptor (mGluR) signaling, which reverses some adult phenotypes of KO mice, accentuated this immature protrusion phenotype in KO mice. Thus, absence of FMRP delays spine stabilization and dysregulated mGluR signaling in FXS may partially normalize this early synaptic defect.
Applying population-based case mix adjustment in managed care: the Johns Hopkins Ambulatory Care Group system. (1994)

When analyzing medical utilization or other health care-related measurements across provider panels, case mix adjustment is required because "illness burden" is often unevenly distributed across these patient populations. This article develops the rationale for case mix adjustment and walks readers through the case mix adjustment process using the Johns Hopkins Ambulatory Care Group (ACG) Case-Mix System as a model. The ACG system is a population-oriented patient classification tool based on diagnoses assigned by providers and found in payors' data systems. The system categorizes patients according to illness burden. It does not categorize visits, encounters, or episodes. ACGs adjust for case mix differences in the analysis of ambulatory, laboratory, pharmacy, and total health care service delivery.
Improvement of the Recovery Factor Using Nano-Metal Particles at the Late Stages of Cyclic Steam Stimulation (2015)

Abstract Cyclic steam stimulation (CSS) has recently re-gaining attention as an alternative to the current applications, such as SAGD or CHOPS. However, low recovery factor and excessive water production are critical problems to tackle. These late-stage experiences require a revisit to the options of recovery improvement and reduction of water production at the mid- and late-stages of the cycles. This research proposes a new approach for this purpose and investigates the effects of nano-metal particles introduced into the reservoir on the recovery factor after several cycles of steam injection. We begin with CSS experiments on heavy-oil saturated sandpacks studying and clarifying the influence of the nanoparticle presence on the efficiency of the process. It is confirmed that the use of nanoparticle in the first place increases the oil recovery factor along with a higher water production. Then, one run of experiment is performed by introducing the nanoparticle in the sixth cycle of CSS treatment. It is found that a substantial increase in the recovery factor is achieved in such a simulated CSS experiment, which cannot be achieved by injecting steam alone. This experimental study on the addition of nickel particles to improve the recovery factor and extend the life of CSS process will not only add value to nano-technology use in the oil industry from a physics point of view, but will also provide insight into the operating parameters for better late- stage CSS project development.
Anti‐tumor activity of CpG‐ODN aerosol in mouse lung metastases (2013)

Studies in preclinical models have demonstrated the superior anti-tumor effect of CpG oligodeoxynucleotides (CpG-ODN) when administered at the tumor site rather than systemically. We evaluated the effect of aerosolized CpG-ODN on lung metastases in mice injected with immunogenic N202.1A mammary carcinoma cells or weakly immunogenic B16 melanoma cells. Upon reaching the bronchoalveolar space, aerosolized CpG-ODN activated a local immune response, as indicated by production of IL-12p40, IFN-γ and IL-1β and by recruitment and maturation of DC cells in bronchoalveolar lavage fluid of mice. Treatment with aerosolized CpG-ODN induced an expansion of CD4+ cells in lung and was more efficacious than systemic i.p. administration against experimental lung metastases of immunogenic N202.1A mammary carcinoma cells, whereas only i.p. delivery of CpG-ODN provided anti-tumor activity, which correlated with NK cell expansion in the lung, against lung metastases of the poorly immunogenic B16 melanoma. The inefficacy of aerosol therapy to induce NK expansion was related to the presence of immunosuppressive macrophages in B16 tumor-bearing lungs, as mice depleted of these cells by clodronate treatment responded to aerosol CpG-ODN through expansion of the NK cell population and significantly reduced numbers of lung metastases. Our results indicate that tumor immunogenicity and the tumor-induced immunosuppressive environment are critical factors to the success of CpG therapy in the lung, and point to the value of routine sampling of the lung immune environment in defining an optimal immunotherapeutic strategy.
Corundum: An Open-Source 100-Gbps Nic (2020)

Corundum is an open-source, FPGA-based prototyping platform for network interface development at up to 100 Gbps and beyond. The Corundum platform includes several core features to enable real-time, high-line-rate operations including: a high-performance datapath, 10G/25G/100G Ethernet MACs, PCI Express gen 3, a custom PCIe DMA engine, and native high-precision IEEE 1588 PTP timestamping. A key feature is extensible queue management that can support over 10,000 queues coupled with extensible transmit schedulers, enabling fine-grained hardware control of packet transmission. In conjunction with multiple network interfaces, multiple ports per interface, and per-port event-driven transmit scheduling, these features enable the development of advanced network interfaces, architectures, and protocols. The software interface to these hardware features is a high-performance driver for the Linux networking stack. The platform also supports scatter/gather DMA, checksum offloading, receive flow hashing, and receive-side scaling. Development and debugging is facilitated by a comprehensive open-source, Python-based simulation framework that includes the entire system from a simulation model of the driver and PCI express interface to the Ethernet interfaces. The power and flexibility of Corundum is demonstrated by the implementation of a microsecond-precision time-division multiple access (TDMA) hardware scheduler to enforce a TDMA schedule at 100 Gbps line rate with no CPU overhead.
Flashover Prevention of High Voltage Piezoelectric Transformers by Thin Film Encapsulation (2010)

Piezoelectric transformers (PTs) are used as step-up voltage elements in many devices. The University of Missouri is developing a PT as an accelerator for an ion beam. In cases where high-voltage pulses are desired, discharges can result from a large electric field near triple point junctions. Due to the small scale of the device, conductive triple point shields are difficult to employ to prevent flashover. This paper presents an investigation of piezoelectric flashover prevention by thin film encapsulation. Dielectric material was deposited on the PT both over the entire device and at specific regions of interest. The dielectric was deposited by evaporation to eliminate gaps at the triple point. The flashover strength is evaluated depending on the dielectric type, thickness, and length. The mechanical loss incurred by the deposition is evaluated to determine if it hinders the motion of the transformer.
Identification of DNA Repair Genes in the Human Genome (1986)

The ubiquitous presence of DNA-damaging agents and the instability of certain chemical bonds in DNA have made it necessary for living organisms to develop DNA repair systems. These repair processes help prevent lesions from interfering with essential DNA functions or from converting into permanent mutations that cause cellular malfunctioning and cell death and in higher organisms contribute to malignancy and possibly aging. In view of the wide spectrum of possible lesions, a network of repair systems has evolved to cope with different types of DNA damage (for an extensive review on DNA damage and repair, see Friedberg 1985). In recent years there have been considerable advances in understanding the mechanism and genetic control of two important repair systems in Escherichia coli: the excision-repair pathway operating at UV-induced DNA lesions and bulky DNA adducts and the adaptive response directed toward alkylation lesions (recently reviewed by Walker 1985). Genetic studies have identified...
Spectroscopic properties of Ti^3+-doped BeAl_2O_4 (1989)

The crystallographic axis dependence of the absorption and photoluminescence spectra of Ti:BeAl2O4 is rationalized by assuming that the (3d)1 electron energy levels are split by the cubic and orthorhombic fields present at the Al site in chrysoberyl. The temperature dependence of the luminescence lifetime and integrated intensity indicates that the lifetime shortening that accompanies temperature increase is due to a nonradiative transition with an activation energy estimated to be 1770 cm−1.
A TOTP-Based Two Factor Authentication Scheme for Hyperledger Fabric Blockchain (2018)

In this paper, we propose a new authentication method to prevent authentication vulnerability of Claim Token method of Membership Service provide in Private BlockChain. We chose Hyperledger Fabric v1.0 using JWT authentication method of membership service. TOTP, which generate OTP tokens and user authentication codes that generate additional time-based password on existing authentication servers, has been applied to enforce security and two-factor authentication method to provide more secure services.
Captodiamine, a putative antidepressant, enhances hypothalamic BDNF expression in vivo by synergistic 5-HT<sub>2c</sub> receptor antagonism and sigma-1 receptor agonism (2013)

The putative antidepressant captodiamine is a 5-HT2c receptor antagonist and agonist at sigma-1 and D3 dopamine receptors, exerts an anti-immobility action in the forced swim paradigm, and enhances dopamine turnover in the frontal cortex. Captodiamine has also been found to ameliorate stress-induced anhedonia, reduce the associated elevations of hypothalamic corticotrophin-releasing factor (CRF) and restore the reductions in hypothalamic BDNF expression. Here we demonstrate chronic administration of captodiamine to have no significant effect on hypothalamic CRF expression through sigma-1 receptor agonism; however, both sigma-1 receptor agonism or 5-HT2c receptor antagonism were necessary to enhance BDNF expression. Regulation of BDNF expression by captodiamine was associated with increased phosphorylation of transcription factor CREB and mediated through sigma-1 receptor agonism but blocked by 5-HT2c receptor antagonism. The existence of two separate signalling pathways was confirmed by immunolocalisation of each receptor to distinct cell populations in the paraventricular nucleus of the hypothalamus. Increased BDNF induced by captodiamine was also associated with enhanced expression of synapsin, but not PSD-95, suggesting induction of long-term structural plasticity between hypothalamic synapses. These unique features of captodiamine may contribute to its ability to ameliorate stress-induced anhedonia as the hypothalamus plays a prominent role in regulating HPA axis activity.
A facile and effective chemiluminescence demonstration experiment (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA facile and effective chemiluminescence demonstration experimentArthur G. Mohan and Nicholas J. Turro Cite this: J. Chem. Educ. 1974, 51, 8, 528Publication Date (Print):August 1, 1974Publication History Received3 August 2009Published online1 August 1974Published inissue 1 August 1974https://doi.org/10.1021/ed051p528RIGHTS & PERMISSIONSArticle Views2314Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Study on the Loadings of Co<sub>3</sub>O<sub>4</sub> Supported on rGO as the Catalyst for Degradation of Orange II in Water by AOPs Based on Sulfate Radicals (2014)

A variety of loadings of Cobalt oxide (Co 3 O 4 ) was successfully supported on the reduced graphene (Co 3 O 4 /rGO) as the catalyst to activate peroxymonosulfate (PMS) to generate sulfate radicals (SO 4 − •) for degrading Orange II in water. The crystal structure of Co 3 O 4 /rGO with different loadings was characterized by X-ray diffraction (XRD), and their catalytic activity was compared in the same conditions. The result showed that the catalyst has an optimum Co 3 O 4 loading. Using the 70.7% loading of Co 3 O 4 in Co 3 O 4 /rGO as the catalyst, 100% decomposition could be achieved within 4 min with 1 mM Orange II, 0.05g/L catalyst, and 10 mM PMS.
Pulmonary vasodilation by acetazolamide during hypoxia is unrelated to carbonic anhydrase inhibition (2006)

Acute hypoxic pulmonary vasoconstriction can be inhibited by high doses of the carbonic anhydrase inhibitor acetazolamide. This study aimed to determine whether acetazolamide is effective at dosing relevant to human use at high altitude and to investigate whether its efficacy against hypoxic pulmonary vasoconstriction is dependent on carbonic anhydrase inhibition by testing other potent heterocyclic sulfonamide carbonic anhydrase inhibitors. Six conscious dogs were studied in five protocols: 1) controls, 2) low-dose intravenous acetazolamide (2 mg.kg(-1).h(-1)), 3) oral acetazolamide (5 mg/kg), 4) benzolamide, a membrane-impermeant inhibitor, and 5) ethoxzolamide, a membrane-permeant inhibitor. In all protocols, unanesthetized dogs breathed spontaneously during the first hour (normoxia) and then breathed 9-10% O(2) for the next 2 h. Arterial oxygen tension ranged between 35 and 39 mmHg during hypoxia in all protocols. In controls, mean pulmonary artery pressure increased by 8 mmHg and pulmonary vascular resistance by 200 dyn.s.cm(-5) (P <0.05). With intravenous acetazolamide, mean pulmonary artery pressure and pulmonary vascular resistance remained unchanged during hypoxia. With oral acetazolamide, mean pulmonary artery pressure increased by 5 mmHg (P < 0.05), but pulmonary vascular resistance did not change during hypoxia. With benzolamide and ethoxzolamide, mean pulmonary artery pressure increased by 6-7 mmHg and pulmonary vascular resistance by 150-200 dyn.s.cm(-5) during hypoxia (P < 0.05). Low-dose acetazolamide is effective against acute hypoxic pulmonary vasoconstriction in vivo. The lack of effect with two other potent carbonic anhydrase inhibitors suggests that carbonic anhydrase is not involved in the mediation of hypoxic pulmonary vasoconstriction and that acetazolamide acts on a different receptor or channel.
Gonorrhea (1993)

Gonorrhea is the most common reportable disease in the United States. In recent years, the epidemiology of this infection has changed as a result of increasing drug abuse, exchange of money and drugs for sex, and sexual promiscuity among teenagers, particularly blacks. Significant numbers of asymptomatic male carriers have been identified, which presents an additional challenge to disease control. Gonococcal infection has become increasingly resistant to traditional antibiotic therapy and now requires the use of newer, more expensive agents. Single-dose oral treatment with cefixime (Suprax) or a quinolone appears to be effective, safe, and practical for patients with uncomplicated gonorrhea. Serious infection and new syndromes caused by gonococci continue to be reported. Because disseminated infections can be fatal, hospitalization and treatment with intravenous antibiotics such as ceftriaxone sodium (Rocephin) or cefotaxime sodium (Claforan) are required.
Real‐time free‐breathing cardiac imaging with self‐calibrated through‐time radial GRAPPA (2016)

Highly accelerated real-time imaging with undersampled radial trajectories without additional calibration data is feasible. Image quality was acceptable for real-time cardiac MRI applications demanding high speed. Magn Reson Med 77:250-264, 2017. © 2016 Wiley Periodicals, Inc.
A Low Voltage Low Power CMOS Delay Element (1995)

A low voltage, low power CMOS delay element is proposed. With unit CMOS inverter load, the delay from 2ns to 10?s is achieved with the power consumption less than 30pW/MHz in 0.8?m CMOS technology. Based on the CMOS thyristor concept, the delay value of the proposed element can be designed in a wide range with the control current. The designed delay value is less sensitive to the supply voltage variation and temperature than those of RC or CMOS inverter based delay elements.
Safety and effectiveness of a portable external automatic defibrillator‐pacemaker (1983)

Sudden cardiac death in the community can be reduced by early resuscitation. The commonest arrhythmia encountered in this setting is ventricular fibrillation. A portable external automatic defibrillator-pacing machine for use by emergency services and laymen after basic training, has recently been introduced. This device has a tongue-abdominal pathway for sensing the electrocardiogram and respiration, as well as delivery of current. In its automatic mode, the machine cannot defibrillate unless the patient's breathing and gag reflex are virtually absent. The decision-making characteristics of the machine were defined in isolation from the patient using simulated ECG signals and recordings of arrhythmias obtained during cardiac surgery and during electrophysiological studies. The pathway was evaluated separately by attaching it to a conventional defibrillator and using it in the elective cardioversion of 15 patients. Electrode sites were examined and creatine phosphokinase (CPK) and creatinine phosphokinase isoenzyme (CPKMB) release determined following conversion. Repeated playback of the same 34 minutes of selected recordings showed that decisions were consistent 95% of the time. Automatic pacing always occurred with asystole. ECG signals less than 0.35 mV in amplitude were not recognized, but a manual override switch could be operated in those circumstances where there was failure to act upon fine ventricular fibrillation. Defibrillation of 50% of the recordings of supraventricular and ventricular tachycardia did occur, but this could not have happened in practice unless the patient was unconscious, and in addition, the operator failed to countermand this decision. The tongue-abdominal pathway yielded good recordings of the ECG.(ABSTRACT TRUNCATED AT 250 WORDS)
Cooperative Inter-cell Interference Mitigation Scheme with Downlink MU-MIMO Beamforming for Dense Wireless LAN Environment (2014)

A cooperative inter-cell interference (ICI) mitigation scheme with transmit beamforming for dense wireless LAN systems is proposed. The proposed scheme applies transmit beamforming used for downlink multiuser MIMO in order to mitigate the effect of ICI and selectively determines whether an access point (AP) performs null beamforming for each station (STA) in overlapping basic service sets (OBSSs) according to the ICI power. Null beamforming is used to suppress ICI if its power exceeds a threshold, otherwise, it is not carried out and the transmit antenna is used to obtain a diversity gain for STAs associated with the AP. Computer simulations confirm that the achievable rate obtained with the proposed scheme is superior to that obtained with either time resource sharing or conventional ICI mitigation in an OBSS environment.
Field-directed assembly of nanowires: identifying directors, disruptors and indices to maximize the device yield (2015)

Individually-addressable nano-electro-mechanical (NEMS) devices have been used to demonstrate sensitive mass detection to the single-proton level, as well as neutral-particle mass spectrometry. The cost of individually securing or patterning such devices is proportional to their number or the chip area covered. This limits statistical support for new research, as well as paths to the commercial availability of extraordinarily sensitive instruments. Field-directed assembly of synthesized nanowires addresses this problem and shows potential for low-cost, large-area coverage with NEMS devices. For positive dielectrophoresis (pDEP) as the main assembly director, the space of field, geometric and material parameters is large, with combinations that can serve either as directors or disruptors for directed assembly. We seek parameter values to obtain the best yield, by introducing a rational framework to reduce trial-and-error. We show that sorting the disruptors by severity and eliminating those weakly coupled to the director, allows reduction of the parameter space. The remaining disruptors are then represented compactly by dimensionless parameters. In the example protocol chosen, a single dimensionless parameter, the yield index, allows minimization of disruptors by the choice of frequency. Following this, the voltage may be selected to maximize the yield. Using this framework, we obtained 94% pre-clamped and 88% post-clamped yield over 57000 nanowire sites. Organizing the parameter space using a director-disruptor framework, with economy introduced by non-dimensional parameters, provides a path to controllably decrease the effort and cost of manufacturing nanoscale devices. This should help in the commercialization of individually addressable nanodevices.