gebhart/patrepeval huggingface dataset:
Straight-chain carbamyl compounds for second harmonic generation (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStraight-chain carbamyl compounds for second harmonic generationCecil V. Francis and George V. D. TiersCite this: Chem. Mater. 1992, 4, 2, 353–358Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/cm00020a023https://doi.org/10.1021/cm00020a023research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry (2011)

To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon inducible transmembrane protein family members, IFITM1, 2 and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. Here we report that IFN prevents emergence of viral genomes from the endosomal pathway, and that IFITM3 is both necessary and sufficient for this function. Notably, viral pseudoparticles were inhibited from transferring their contents into the host cell cytosol by IFN, and IFITM3 was required and sufficient for this action. We further demonstrate that IFN expands Rab7 and LAMP1-containing structures, and that IFITM3 overexpression is sufficient for this phenotype. Moreover, IFITM3 partially resides in late endosomal and lysosomal structures, placing it in the path of invading viruses. Collectively our data are consistent with the prediction that viruses that fuse in the late endosomes or lysosomes are vulnerable to IFITM3's actions, while viruses that enter at the cell surface or in the early endosomes may avoid inhibition. Multiple viruses enter host cells through the late endocytic pathway, and many of these invaders are attenuated by IFN. Therefore these findings are likely to have significance for the intrinsic immune system's neutralization of a diverse array of threats.
Epitaxial waveguides of aluminum garnet (1993)

Waveguides of high refractive index aluminum garnets have been epitaxially grown on 〈111〉-oriented crystal wafers of yttrium aluminum garnet (Y3Al5O12, YAG) and clad with epitaxial YAG. Epitaxy was by the liquid phase solution growth technique from supercooled mixtures of lead oxide and boron oxide, as is common for the epitaxy of iron garnets. One composition which is particularly suited for waveguides is Tb1.78Lu1.22Al5O12, which has a refractive index at 632.8 nm of about 1.854, as compared with 1.828 for YAG, and has no absorption bands in the visible and near IR spectra. Since aluminum garnets have melting points above 1900 °C, such waveguides should find application in high temperature optical sensors.
A butterfly structured design of the hybrid transform coding scheme (2013)

The hybrid transform coding scheme that alternates amongst the asymmetric discrete sine transform (ADST) and the discrete cosine transform (DCT) depending on the boundary prediction conditions, is an efficient tool for video and image compression. It optimally exploits the statistical characteristics of prediction residual, thereby achieving significant coding performance gains over the conventional DCT-based approach. A practical concern lies in the intrinsic conflict between transform kernels of ADST and DCT, which prevents a butterfly structured implementation for parallel computing. Hence the hybrid transform coding scheme has to rely on matrix multiplication, which presents a speed-up barrier due to under-utilization of the hardware, especially for larger block sizes. In this work, we devise a novel ADST-like transform whose kernel is consistent with that of DCT, thereby enabling butterfly structured computation flow, while largely retaining the performance advantages of hybrid transform coding scheme in terms of compression efficiency. A prototype implementation of the proposed butterfly structured hybrid transform coding scheme is available in the VP9 codec repository.
Adaptive modulation of bilateral filtering based on a practical noise model for streaking and noise reduction in multi-slice CT (2010)

We have recently developed a locally-adaptive method for noise control in CT based upon bilateral filtering. Different from the previous adaptive filters, which were locally adaptive by adjusting the filter strength according to local photon statistics, our use of bilateral filtering in projection data incorporates a practical CT noise model and takes into account the local structural characteristics, and thus can preserve edge information in the projection data and maintain the spatial resolution. Despite the incorporation of the CT noise model and local structural characteristics in the bilateral filtering, the noise-resolution properties of the filtered image are still highly dependent on predefined parameters that control the weighting factors in the bilateral filtering. An inappropriate selection of these parameters may result in a loss of spatial resolution or an insufficient reduction of noise. In this work, we employed an adaptive strategy to modulate the bilateral filtering strength according to the noise-equivalent photon numbers determined from each projection measurement. We applied the proposed technique to head/neck angiographic CT exams, which had highly non-uniform attenuation levels during the scan. The results demonstrated that the technique can effectively reduce the noise and streaking artifacts caused by high attenuation, while maintaining the reconstruction accuracy in less attenuating regions.
Smart (2007)

Graphical User Interface (GUI) APplications (GAPs) are ubiquitous and provide various services. Since many GAPs are not designed to exchange information (i.e., interoperate), companies replace legacy GAPs with web services, that are designed to interoperate over the Internet. However, it is laborious and inefficient to create unit test cases to test the web services.
Postprocessing of L1 GPS radio occultation signals recorded in open‐loop mode (2009)

GPS Radio Occultation (RO) profiling from low‐Earth orbiting satellites is operationally used for numerical weather forecasting and is starting to be used for climate studies. Obtaining high‐quality observations near the surface requires recording of RO signals in model‐aided open loop (OL) mode by the GPS receiver. Postprocessing of the OL RO signals is different from that of the signals recorded in traditional phase‐locked loop (PLL) mode. It requires modeling of the signal frequency for connection of the phase between samples and removal of the GPS navigation data modulation (NDM). It is important that the postprocessing does not introduce errors (biases) in the connected phase. This paper describes the postprocessing of the OL RO signals which does not depend on the receiver model. The postprocessing includes: modeling of the RO signal frequency from refractivity climatology and the subsequent adjustment of this model by use of feedback which makes the postprocessing model‐independent; internal (as in PLL) removal of NDM and the use of externally recorded NDM bit sequence. Statistical comparison of the refractivity inversion results demonstrates that external demodulation of RO signals reduces the inversion bias in the tropical lower troposphere by about 0.5%.
Rhenium Metal and Rhenium Nitride Thin Films Grown by Atomic Layer Deposition (2018)

Rhenium is both a refractory metal and a noble metal that has attractive properties for various applications. Still, synthesis and applications of rhenium thin films have been limited. We introduce herein the growth of both rhenium metal and rhenium nitride thin films by the technologically important atomic layer deposition (ALD) method over a wide deposition temperature range using fast, simple, and robust surface reactions between rhenium pentachloride and ammonia. Films are grown and characterized for compositions, surface morphologies and roughnesses, crystallinities, and resistivities. Conductive rhenium subnitride films of tunable composition are obtained at deposition temperatures between 275 and 375 °C, whereas pure rhenium metal films grow at 400 °C and above. Even a just 3 nm thick rhenium film is continuous and has a low resistivity of about 90 μΩ cm showing potential for applications for which also other noble metals and refractory metals have been considered.
Next-Generation Optical Sensing Technologies for Exploring Ocean Worlds—NASA FluidCam, MiDAR, and NeMO-Net (2019)

We highlight three emerging NASA optical technologies that enhance our ability to remotely sense , analyze, and explore ocean worlds – FluidCam and fluid lensing, MiDAR, and NeMO-Net. Fluid lensing is the first remote sensing technology capable of imaging through ocean waves without distortions in 3D at sub-cm resolutions. Fluid lensing and the purpose-built FluidCam CubeSat instruments have been used to provide refraction-corrected 3D multispectral imagery of shallow marine systems from unmanned aerial vehicles (UAVs). Results from repeat 2013 and 2016 airborne fluid lensing campaigns over coral reefs in American Samoa present a promising new tool for monitoring fine-scale ecological dynamics in shallow aquatic systems tens of square kilometers in area. MiDAR is a recently-patented active multispectral remote sensing and optical communications instrument which evolved from FluidCam. MiDAR is being tested on UAVs and autonomous underwater vehicles (AUVs) to remotely sense living and nonliving structures in light-limited and analog planetary science environments. MiDAR illuminates targets with high-intensity narrowband structured optical radiation to measure an object’s spectral reflectance while simultaneously transmitting data. MiDAR is capable of remotely sensing reflectance at fine spatial and temporal scales, with a signal-to-noise ratio 10-103 times higher than passive airborne and spaceborne remote sensing systems, enabling high-framerate multispectral sensing across the ultraviolet, visible, and near-infrared spectrum. Preliminary results from a 2018 mission to Guam show encouraging applications of MiDAR to imaging coral from airborne and underwater platforms whilst transmitting data across the air-water interface. Finally, we share NeMO-Net, the Neural Multi-Modal Observation & Training Network for Global Coral Reef Assessment. NeMO-Net is a machine learning technology under development that exploits high-resolution data from FluidCam and MiDAR for augmentation of low-resolution airborne and satellite remote sensing. NeMO-Net is intended to harmonize the growing diversity of 2D and 3D remote sensing with in situ data into a single open-source platform for assessing shallow marine ecosystems globally using active learning for citizen-science based training. Preliminary results from four-class coral classification have an accuracy of 94.4%. Together, these maturing technologies present promising scalable, practical, and cost-efficient innovations that address current observational and technological challenges in optical sensing of marine systems.
Design, Synthesis, and Biological Evaluation of PKD Inhibitors (2011)

Protein kinase D (PKD) belongs to a family of serine/threonine kinases that play an important role in basic cellular processes and are implicated in the pathogenesis of several diseases. Progress in our understanding of the biological functions of PKD has been limited due to the lack of a PKD-specific inhibitor. The benzoxoloazepinolone CID755673 was recently reported as the first potent and kinase-selective inhibitor for this enzyme. For structure-activity analysis purposes, a series of analogs was prepared and their in vitro inhibitory potency evaluated.
Identification of Novel Malaria Transmission-Blocking Vaccine Candidates (2021)

Control measures have significantly reduced malaria morbidity and mortality in the last two decades; however, the downward trends have stalled and have become complicated by the emergence of COVID-19. Significant efforts have been made to develop malaria vaccines, but currently only the RTS,S/AS01 vaccine against <i>Plasmodium falciparum</i> has been recommended by the WHO, for widespread use among children in sub-Saharan Africa. The efficacy of RTS,S/AS01 is modest, and therefore the development of more efficacious vaccines is still needed. In addition, the development of transmission-blocking vaccines (TBVs) to reduce the parasite transmission from humans to mosquitoes is required toward the goal of malaria elimination. Few TBVs have reached clinical development, and challenges include low immunogenicity or high reactogenicity in humans. Therefore, novel approaches to accelerate TBV research and development are urgently needed, especially novel TBV candidate discovery. In this mini review we summarize the progress in TBV research and development, novel TBV candidate discovery, and discuss how to accelerate novel TBV candidate discovery.
CSVD: clustering and singular value decomposition for approximate similarity search in high-dimensional spaces (2003)

Nearest-neighbor search of high-dimensionality spaces is critical for many applications, such as content-based retrieval from multimedia databases, similarity search of patterns in data mining, and nearest-neighbor classification. Unfortunately, even with the aid of the commonly used indexing schemes, the performance of nearest-neighbor (NN) queries deteriorates rapidly with the number of dimensions. We propose a method, called Clustering with Singular Value Decomposition (CSVD), which supports efficient approximate processing of NN queries, while maintaining good precision-recall characteristics. CSVD groups homogeneous points into clusters and separately reduces the dimensionality of each cluster using SVD. Cluster selection for NN queries relies on a branch-and-bound algorithm and within-cluster searches can be performed with traditional or in-memory indexing methods. Experiments with texture vectors extracted from satellite images show that CSVD achieves significantly higher dimensionality reduction than plain SVD for the same normalized mean squared error (NMSE), which translates into a higher efficiency in processing approximate NN queries.
Comparator-based buffer with resistive error correction (2010)

A comparator-based buffer is proposed to enhance the driving capability of high-gain amplifiers with switched-capacitor loads. A simple correction scheme using a resistor in the charging path and a correction phase reduces the overshoot of the output voltage. SPECTRE simulations verify the effectiveness of the proposed scheme.
The Next Frontier in the Molecular Biology of the Opioid System (1988)

The analgesic and euphoric properties of some plant alkaloids such as morphine have been known and exploited for centuries. In contrast, only during the last twenty years have we begun to unravel the molecular basis by which opiates exert their effects, mechanisms important to our general understanding of the nervous system. The analgesic response to opiates is the result of a cascade of biochemical events that are triggered by the interaction of the opiate with specific macromolecular components found on the membranes of nervous system tissues, the opioid receptors. The endogenous ligands of these receptors are small peptides, the opioid peptides. Although much has been learned about the structures and the mode of synthesis of the opioid peptides, little is understood about the structure of their receptors. The application of molecular genetic techniques was of great importance to the studies of the opioid peptides. It is now expected that this same technology will unravel the physical mysteries of the opioid receptors.
Experimental studies of proton-implanted GaAs-AlGaAs multiple-quantum-well modulators for low-photocurrent applications (1994)

We describe the first attempts to control photocurrent, and thus power dissipation, in surface-normal multiple-quantum-well (MQW) modulators. We have made detailed experimental studies of proton-implanted p-i-n GaAs-Al/sub x/Ga/sub 1-x/As MQW modulators having barrier layers of x=0.3, 0.45, and 1.0. Structures were implanted to levels of 1/spl times/10/sup 12/ cm/sup -2/, 1/spl times/10/sup 13/ cm/sup -2/, and 1/spl times/10/sup 14/ cm/sup -2/. Photocurrent progressively decreased with increasing implant-dose and barrier mole fraction (x). Exciton linewidths showed a strong voltage and implant dose dependence, demonstrating a tradeoff between photocurrent and modulation performance. We obtained our best results with x=1.0 barriers. For example, 1/spl times/10/sup 13/ cm/sup -2/-implanted asymmetric Fabry-Perot modulators were realized in which the optical performance was similar to that of unimplanted devices. The photocurrent responsivity was, however, only 0.007 A/W at 12.5 V bias. We report measurements of carrier lifetime in these materials that show the reduction in photocurrent arises from a reduction in lifetime due to implant-induced damage. In addition, the reduced lifetime decreases the optically-excited quantum-well carrier population, leading to an increase in cw saturation intensity. Specifically, 1/spl times/10/sup 13/ cm/sup -2/-implanted devices with x=1.0 have a saturation intensity of roughly 45 kW/cm/sup 2/, while unimplanted devices have 3.5 kW/cm/sup 2/. Asymmetric self electro-optic effect devices (A-SEED's) are demonstrated, and power dissipation issues associated with the use of low-photocurrent modulators in integrated systems are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Strategies for induction of HIV‐1 envelope‐reactive broadly neutralizing antibodies (2021)

A fully protective HIV-1 vaccine needs to induce durable high titers of bnAbs that can be generated by a sequential set of Env immunogens for expansion and maturation of bnAb B cell lineages in a permitted immunological environment. Moreover, multiple specificities of bnAbs will be required to be sufficiently broad to prevent the escape of HIV-1 strains during transmission.
Impact of Backbone Tether Length and Structure on the Electrochemical Performance of Viologen Redox Active Polymers (2016)

The design of chemically stable and electrochemically reversible redox active polymers (RAPs) is of great interest for energy storage technologies. Particularly, RAPs are new players for flow batteries relying on a size-exclusion based mechanism of electrolyte separation, but few studies have provided detailed molecular understanding of redox polymers in solution. Here, we use a systematic molecular design approach to investigate the impact of linker and redox-pendant electronic interactions on the performance of viologen RAPs. We used scanning electrochemical microscopy, cyclic voltammetry, bulk electrolysis, temperature-dependent absorbance, and spectroelectrochemistry to study the redox properties, charge transfer kinetics, and self-exchange of electrons through redox active dimers and their equivalent polymers. Stark contrast was observed between the electrochemical properties of viologen dimers and their corresponding polymers. Electron self-exchange kinetics in redox active dimers that only differ by their tether length and rigidity influences their charge transfer properties. Predictions from the Marcus–Hush theory were consistent with observations in redox active dimers, but they failed to fully capture the behavior of macromolecular systems. For example, polymer bound viologen pendants, if too close in proximity, do not retain chemical reversibility. In contrast to polymer films, small modifications to the backbone structure decisively impact the bulk electrolysis of polymer solutions. This first comprehensive study highlights the careful balance between electronic interactions and backbone rigidity required to design RAPs with superior electrochemical performance.
Phospholipase C Activator <i>m</i>-3M3FBS Protects against Morbidity and Mortality Associated with Sepsis (2012)

Although phospholipase C (PLC) is a crucial enzyme required for effective signal transduction and leukocyte activation, the role of PLC in polymicrobial sepsis remains unclear. In this study, we show that the direct PLC activator m-3M3FBS treatment significantly attenuates vital organ inflammation, widespread immune cell apoptosis, and mortality in a mouse sepsis model induced by lethal cecal ligation and puncture challenge. Mechanistically, m-3M3FBS-dependent protection was largely abolished by pretreatment of mice with the PLC-selective inhibitor U-73122, thus confirming PLC agonism by m-3M3FBS in vivo. PLC activation enhanced the bactericidal activity and hydrogen peroxide production of mouse neutrophils, and it also enhanced the production of IFN-γ and IL-12 while inhibiting proseptic TNF-α and IL-1β production in cecal ligation and puncture mice. In a second model of sepsis, PLC activation also inhibited the production of TNF-α and IL-1β following systemic LPS challenge. In conclusion, we show that agonizing the central signal transducing enzyme PLC by m-3M3FBS can reverse the progression of toxic shock by triggering multiple protective downstream signaling pathways to maintain organ function, leukocyte survival, and to enhance microbial killing.
Inadvertent Cervical Epidural Catheter Placement via the Caudal Route Using Electrical Stimulation (2004)

Inadvertent placement of an epidural catheter in the cervical region via the caudal route is described in an infant who underwent revision of a fundoplication. We attempted electrical stimulation (the Tsui test) via the epidural catheter to confirm correct placement and positioning of the catheter tip. In this case, the epidural catheter was inadvertently advanced to the cervical region, resulting in stimulation of the phrenic nerve. These diaphragmatic twitches were misinterpreted as chest wall twitches, and it was incorrectly assumed that the catheter was in the thoracic region. To avoid misinterpretation of the stimulation level, the catheter should be continuously stimulated while it is advanced. We also recommend that the catheter length be estimated before insertion (although doing so did not help in this case) and that the catheter position be radiographically confirmed after surgery.