gebhart/patrepeval huggingface dataset:
Policy driven configuration management of network devices (2002)

Outlines a comprehensive and implemented concept for modeling configuration tasks. Examples, especially the configuration of different hubs, show that the model is feasible and its complexity justified. We show how detailed configuration operations can be mapped to existing management tools. To use this concept, it is thus not necessary to buy new tools but rather to identify the functionality of existing tools and specify configuration policies. Our approach is modular and flexible, thereby allowing for changes at any level within the model without influencing the other levels directly. Furthermore, implicit policies found in configuration tasks have been extracted and specified explicitly. This mechanism caters for a proactive and strategic management and configuration of devices. The model is not limited to the configuration of network devices but can be equally extended to include configuration processes for end systems and distributed applications.
Method of and apparatus for measuring characteristic features of fibrous material (1985)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Christoph Thomann; Method of and apparatus for measuring characteristic features of fibrous material. J. Acoust. Soc. Am. 1 June 1985; 77 (6): 2207. https://doi.org/10.1121/1.391690 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D (2004)

Anandamide (an endocannabinoid) and other bioactive long-chain NAEs (N-acylethanolamines) are formed by direct release from N-acyl-PE (N-acyl-phosphatidylethanolamine) by a PLD (phospholipase D). However, the possible presence of a two-step pathway from N-acyl-PE has also been suggested previously, which comprises (1) the hydrolysis of N-acyl-PE to N-acyl-lysoPE by PLA1/PLA2 enzyme(s) and (2) the release of NAEs from N-acyllysoPE by lysoPLD (lysophospholipase D) enzyme(s). In the present study we report for the first time the characterization of enzymes responsible for this pathway. The PLA1/PLA2 activity for N-palmitoyl-PE was found in various rat tissues, with the highest activity in the stomach. This stomach enzyme was identified as group IB sPLA2 (secretory PLA2), and its product was determined as N-acyl-1-acyl-lysoPE. Recombinant group IB, IIA and V of sPLA2s were also active with N-palmitoyl-PE, whereas group X sPLA2 and cytosolic PLA2a were inactive. In addition, we found wide distribution of lysoPLD activity generating N-palmitoylethanolamine from N-palmitoyl-lysoPE in rat tissues, with higher activities in the brain and testis. Based on several lines of enzymological evidence, the lysoPLD enzyme could be distinct from the known N-acyl-PE-hydrolysing PLD. sPLA2-IB dose dependently enhanced the production of N-palmitoylethanolamine from N-palmitoyl-PE in the brain homogenate showing the lysoPLD activity. N-Arachidonoyl-PE and N-arachidonoyl-lysoPE as anandamide precursors were also good substrates of sPLA2-IB and the lysoPLD respectively. These results suggest that the sequential actions of PLA2 and lysoPLD may constitute another biosynthetic pathway for NAEs, including anandamide.
Strain effects in GaN epilayers grown on different substrates by metal organic vapor phase epitaxy (2010)

For practical applications, it is important to control strain by carefully tuning growth conditions for stress modification. Strain can have a pronounced impact on device behavior and is caused by extrinsic thermal stress and a tunable intrinsic growth stress. The impact of strain on GaN epilayers was investigated by photoluminescence and high resolution x-ray diffraction (XRD). The GaN samples were grown by metal organic vapor phase epitaxy, on sapphire, 4H–SiC, freestanding GaN and Si (111) substrates. Both free and bound exciton transitions were observed at low temperature, and their energy shift was analyzed with respect to the strain values derived from XRD. We also characterized the valence band split and the GaN bandgap as a function of the strain at 4 K.
A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line (2012)

Our results suggest that a natural fraction extracted from Caesalpinia spinosa in combination with conventional chemotherapy in combination with natural products on leukemia cells may increase therapeutic effectiveness in relation to leukemia.
More than just another face in the crowd: superior detection of threatening facial expressions in children and adults (2008)

Threatening facial expressions can signal the approach of someone or something potentially dangerous. Past research has established that adults have an attentional bias for angry faces, visually detecting their presence more quickly than happy or neutral faces. Two new findings are reported here. First, evidence is presented that young children share this attentional bias. In five experiments, young children and adults were asked to find a picture of a target face among an array of eight distracter faces. Both age groups detected threat-relevant faces--angry and frightened--more rapidly than non-threat-relevant faces (happy and sad). Second, evidence is presented that both adults and children have an attentional bias for negative stimuli overall. All negative faces were detected more quickly than positive ones in both age groups. As the first evidence that young children exhibit the same superior detection of threatening facial expressions as adults, this research provides important support for the existence of an evolved attentional bias for threatening stimuli.
Beyond Consent: Building Trusting Relationships With Diverse Populations in Precision Medicine Research (2018)

With the growth of precision medicine research on health data and biospecimens, research institutions will need to build and maintain long-term, trusting relationships with patient-participants. While trust is important for all research relationships, the longitudinal nature of precision medicine research raises particular challenges for facilitating trust when the specifics of future studies are unknown. Based on focus groups with racially and ethnically diverse patients, we describe several factors that influence patient trust and potential institutional approaches to building trustworthiness. Drawing on these findings, we suggest several considerations for research institutions seeking to cultivate long-term, trusting relationships with patients: (1) Address the role of history and experience on trust, (2) engage concerns about potential group harm, (3) address cultural values and communication barriers, and (4) integrate patient values and expectations into oversight and governance structures.
Design, Synthesis, and Antimycobacterial Property of PEG–bis(INH) Conjugates (2012)

Poly(ethylene glycol) derivatives of isoniazid with varying molecular weight of poly(ethylene glycol) were designed as antimycobacterial agents. Poly(ethylene glycol)-diacrylate of three different molecular weights (MW 258, 575, and 700) was conjugated with isoniazid by the Michael addition approach. The poly(ethylene glycol)-bis(isoniazid) conjugates thus obtained were completely characterized by FT-IR, (1)H and (13)C NMR, and ESI-MS spectroscopic techniques. Comparative MTT assay of the poly(ethylene glycol)-bis(isoniazid) conjugates showed much lower cytotoxicity than the neat isoniazid. MIC studies on Mycobaterium tuberculosis H37Rv showed potential antimycobacterial activity than the free isoniazid on a molar basis. The poly(ethylene glycol)-bis(isoniazid) conjugates were successfully radiolabeled with 99m-Technetium with more than 97% efficiency and stability to assess their in vivo fate. The (99m)Tc labeled poly(ethylene glycol)-bis(isoniazid) conjugates showed higher blood retention time in New Zealand rabbits which increased with increasing molecular weight of poly(ethylene glycol). Biodistribution studies in infection-induced murine models (BALB/c mice) showed significant retention of these conjugates at the site of infection for 72 h. The results of this study illustrate the potential utility of the PEGylated isoniazid conjugates as long circulating carriers for improved antitubercular drug therapy.
The material design to reduce outgassing in acetal-based chemically amplified resist for EUV lithography (2006)

In case of EUV lithography, resist material needs to be developed to improve high sensitivity and to minimize outgassing. The outgassing segments from resist were mainly from PAG decomposition. The new type PAG was synthesized by modifying cation group of the sulfonium salt. The sensitivity of the PAG could be enhanced by loading electron withdrawing group on the PAG, which has low volatility during EUV exposure. Then the newly developed PAGs were capable to reduce outgassing during EUV exposure maintaining high acid generating efficiency against EB and EUV exposure. The other approaches to improve the resist sensitivity and minimizing outgassing property were to design PHS based polymer platform with bulky acetal group. The various kind of acetal groups were simulated to determine the Van der Waals volume. The bulkiness of the protection group is effective to both a) increasing inhibition rate of the resist matrix and b) boiling points of deprotected group. The optimum protection ratio has been studied to obtain proper dissolution rate changes before and after exposure. The resist sensitivity is depend on the protection ratio of the bulky acetal group. By modifying PAG and optimizing bulky acetal group in the polymer, it is possible to minimize the amount of the outgassing segments during EUV exposure maintaining high resist sensitivity. The EUV exposure was demonstrated. It was observed that the resist had a high resolution capability in EUV exposure.
Persistent endotheliopathy in the pathogenesis of long COVID syndrome (2021)

Collectively, our findings demonstrate that sustained endotheliopathy is common in convalescent COVID-19 and raise the intriguing possibility that this may contribute to long COVID pathogenesis.
[Deficiencies of interferon production in children]. (1984)

Defective production of either alpha, beta or gamma interferon has been observed in association with severe infections, hematological disorders or immunosuppression. The secretion of gamma interferon can be used as a marker of T lymphocyte function in cases of qualitative T cell defects. In rare patients, a selective defect of interferon production is associated with severe of persistent infections and in some cases with polyclonal immunoblastic proliferation in the absence of other detectable immuno-deficiency. The secondary defect of natural killer cytotoxicity observed in such patients can be reversed by interferon therapy. This new approach to clinical investigation and therapy is likely to widen with the study of other immunoregulatory mediators.
Multiple Access Protocols for Mobile Communications: GPRS, UMTS and Beyond (2002)

From the Publisher:
A comprehensive discussion of multiple access protocols for cellular systems and the consideration of the specific constraints and capabilities of second and third generation systems regarding the multiple access protocols. Beginning by introducing the cellular concept and discussing second and third generation cellular communication systems, including the evolution from these systems to IP-based systems, the authors then identify the requirements for and problems related to multiple access. In accordance with ETSI and 3GPP standards, a split is made into basic multiple access schemes such as CDMA, TDMA and FDMA and multiple access protocols. The pros and cons of CDMA and TDMA for third generation systems are discussed as well as medium access in GSM, GPRS and UMTS, essentially based on R-ALOHA protocols in all these systems. Data access delay and voice dropping performance is assessed and the different UTRA modes are considered.
Provides an accessible text for individuals with little prior knowledge of cellular communication systems or multiple access protocols 
Provides an overview of existing material on cellular communications, multiple access protocols and a combination of the two 
Presents extensive research carried out by the authors including extended packet reservation multiple access protocols such as TDMA and CDMA, protocol enhancements and modelling of the physical layer 
A valuable reference resource for researchers and engineers in the field of cellular communications and packet-based communications, as well as postgraduate and research students in this rapidly evolving field.
Strategic Design of an Effective β-Lactamase Inhibitor (2008)

In an effort to devise strategies for overcoming bacterial beta-lactamases, we studied LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone inhibitor. By possessing a catecholic functionality that resembles a natural bacterial siderophore, LN-1-255 is unique among beta-lactamase inhibitors. LN-1-255 combined with piperacillin was more potent against Escherichia coli DH10B strains bearing bla(SHV) extended-spectrum and inhibitor-resistant beta-lactamases than an equivalent amount of tazobactam and piperacillin. In addition, LN-1-255 significantly enhanced the activity of ceftazidime and cefpirome against extended-spectrum cephalosporin and Sme-1 containing carbapenem-resistant clinical strains. LN-1-255 inhibited SHV-1 and SHV-2 beta-lactamases with nm affinity (K(I) = 110 +/- 10 and 100 +/- 10 nm, respectively). When LN-1-255 inactivated SHV beta-lactamases, a single intermediate was detected by mass spectrometry. The crystal structure of LN-1-255 in complex with SHV-1 was determined at 1.55A resolution. Interestingly, this novel inhibitor forms a bicyclic aromatic intermediate with its carbonyl oxygen pointing out of the oxyanion hole and forming hydrogen bonds with Lys-234 and Ser-130 in the active site. Electron density for the "tail" of LN-1-255 is less ordered and modeled in two conformations. Both conformations have the LN-1-255 carboxyl group interacting with Arg-244, yet the remaining tails of the two conformations diverge. The observed presence of the bicyclic aromatic intermediate with its carbonyl oxygen positioned outside of the oxyanion hole provides a rationale for the stability of this inhibitory intermediate. The 2'-substituted penicillin sulfone, LN-1-255, is proving to be an important lead compound for novel beta-lactamase inhibitor design.
Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at a stem moiety (2007)

This paper describes the synthesis and properties of a novel molecular beacon (MB) containing a benzene-phosphate backbone at the stem moieties. Fluorescent intensity of MBs was found to be stabilized by introducing a benzene-phosphate backbone at stem moieties.
αEβ7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis (2007)

Various T cell adhesion molecules and their cognate receptors on target cells promote T cell receptor (TCR)-mediated cell killing. In this report, we demonstrate that the interaction of epithelial cell marker E-cadherin with integrin alpha(E)(CD103)beta(7), often expressed by tumor-infiltrating lymphocytes (TILs), plays a major role in effective tumor cell lysis. Indeed, we found that although tumor-specific CD103(+) TIL-derived cytotoxic T lymphocyte (CTL) clones are able to kill E-cadherin(+)/intercellular adhesion molecule 1(-) autologous tumor cells, CD103(-) peripheral blood lymphocyte (PBL)-derived counterparts are inefficient. This cell killing is abrogated after treatment of the TIL clones with a blocking anti-CD103 monoclonal antibody or after targeting E-cadherin in the tumor using ribonucleic acid interference. Confocal microscopy analysis also demonstrated that alpha(E)beta(7) is recruited at the immunological synapse and that its interaction with E-cadherin is required for cytolytic granule polarization and subsequent exocytosis. Moreover, we report that the CD103(-) profile, frequently observed in PBL-derived CTL clones and associated with poor cytotoxicity against the cognate tumor, is up-regulated upon TCR engagement and transforming growth factor beta1 treatment, resulting in strong potentiation of antitumor lytic function. Thus, CD8(+)/CD103(+) tumor-reactive T lymphocytes infiltrating epithelial tumors most likely play a major role in antitumor cytotoxic response through alpha(E)beta(7)-E-cadherin interactions.
Simulation of Oxy-Coal Combustion in a 100 kW<sub>th</sub> Test Facility Using RANS and LES: A Validation Study (2012)

Oxy-fuel combustion of solid fuels, often performed in a mixture of oxygen and wet or dry recycled carbon dioxide, has gained significant interest in the last two decades as one of the leading carbon capture technologies in power generation. This paper presents a numerical study on oxy-fuel combustion of lignite coal in a 100 kWth test facility using Large-Eddy Simulation (LES) and Reynolds-averaged Navier–Stokes (RANS) approaches, along with radiation and char combustion submodels properly modified for the CO2-rich environment. The performance of different turbulence models is investigated by comparing their predictions with experimental measurements of velocity and species concentrations as well as gas and particle temperatures. Results show that although agreeing reasonably with the measured mean axial and tangential velocity, all the RANS turbulence models used in this study underestimate the internal recirculation zone size and the turbulence mixing intensity in the char combustion zone. The standard k–ε and RNG k–ε models with default model constants fail to predict accurately the flow and mixing process associated with the staging stream and perform poorly on the oxygen concentration prediction. The SST k–ω model captures most of the flow regimes and improves the prediction of oxygen diffusion than other turbulent-viscosity models. LES can resolve some of the large-scale turbulent structures of the swirling flow in the burner quarl and of the staging stream downstream of the burner, better matching the measured internal recirculation zone size, the entrainment of oxygen from the staging stream, and the overall flame length than the RANS approaches. The unsteady LES approach captures the dynamic characteristics of oxy-coal combustion, such as the attached volatiles flame and the mixing between the recirculated hot gases and the unburned burner streams as well as the stable coal particle devolatilization and ignition in the quarl, which indicates good flame stability. The simulation shows that oxidation reactions dominate char consumption in oxy-fuel combustion. However, gasification reactions can be important locally in the fuel-rich zone of the volatiles-flame and the char-combustion regions, where the temperature is high and the oxygen concentration is low.
Indoles from 2‐Methylnitrobenzenes by Condensation with Formamide Acetals Followed by Reduction: 4‐Benzyloxyindole (2003)

Abstract Indoles from 2‐Methylnitrobenzenes by Condensation with Formamide Acetals Followed by Reduction: 4‐Benzyloxyindole intermediate: 6‐benzyloxy‐2‐nitrotoluene intermediate: (E)‐6‐benzyloxy‐2‐nitro‐β‐pyrrolidinostyrene and (E)‐6‐benzyloxy‐β‐dimethylamino‐2‐nitrostyrene product: 4‐benzyloxyindole intermediate: pyrrolidine enamine, mp 108–110° (MeOH), and N,N‐dimethylenamine
Programmable photonic signal processor chip for radiofrequency applications (2015)

Integrated microwave photonics, an emerging technology combining radio frequency (RF) engineering and integrated photonics, has great potential to be adopted for wideband analog processing applications. However, it has been a challenge to provide photonic integrated circuits with equal levels of function flexibility as compared with their electronic counterparts. Here, we introduce a disruptive approach to tackle this need, which is analogous to an electronic field-programmable gate array. We use a grid of tunable Mach–Zehnder couplers interconnected in a two-dimensional mesh network, each working as a photonic processing unit. Such a device is able to be programmed into many different circuit topologies and thereby provide a diversity of functions. This paper provides, to the best of our knowledge, the first ever demonstration of this concept and shows that a programmable chip with a free spectral range of 14 GHz enables RF filters featuring continuous, over-two-octave frequency coverage, i.e., 1.6–6 GHz, and variable passband shaping ranging from a 55 dB extinction notch filter to a 1.6 GHz bandwidth flat-top filter.
A Variational Principle for Reconstruction of Elastic Deformations in Shear Deformable Plates and Shells (2003)

A variational principle is formulated for the inverse problem of full-field reconstruction of three-dimensional plate/shell deformations from experimentally measured surface strains. The formulation is based upon the minimization of a least squares functional that uses the complete set of strain measures consistent with linear, first-order shear-deformation theory. The formulation, which accommodates for transverse shear deformation, is applicable for the analysis of thin and moderately thick plate and shell structures. The main benefit of the variational principle is that it is well suited for C(sup 0)-continuous displacement finite element discretizations, thus enabling the development of robust algorithms for application to complex civil and aeronautical structures. The methodology is especially aimed at the next generation of aerospace vehicles for use in real-time structural health monitoring systems.
Effects of deletion of the cytoplasmic domain upon surface expression and membrane stability of a viral envelope glycoprotein. (1987)

The envelope protein (gp52) of Friend spleen focus-forming virus (F-SFFV) is defective in its intracellular transport and accumulates in the rough endoplasmic reticulum of F-SFFV-infected cells. This defect in transport has been attributed to the lack of a cytoplasmic domain, and possible loss of signals required for transport to the cell surface. The mature form of gp52, designated gp65, is also reported to be secreted from SFFV-infected cells. To determine the specific changes in the envelope protein which may lead to its lack of transport and to its lack of stability in associating with membranes, the 3' end of the F-SFFV envelope gene, which encodes the transmembrane domain, was inserted in place of the normal 3' end of the Friend murine leukemia virus genome. This chimeric envelope gene was expressed using the vaccinia virus expression system. The chimeric gp70/p15E glycoprotein molecule lacks the cytoplasmic tail residues and as a consequence is about 3300 daltons smaller. The chimeric PrEnv molecule was found to be cleaved efficiently as indicated by pulse-chase experiments. Immunofluorescence studies demonstrate that the chimeric molecule is efficiently transported to the surface of cells, unlike the SFFV gp52 glycoprotein. The chimeric molecule was found to be unstable in its membrane association and is released into the culture medium. These results indicate that the changes in the membrane spanning region and the lack of a cytoplasmic tail do not determine the defective transport of gp52, but may determine the stability of its association with membranes.