gebhart/patrepeval huggingface dataset:
Development of 2-D Bi-SQUID Arrays With High Linearity (2013)

We develop a two-dimensional (2-D) superconducting quantum interference filter (SQIF) array based on the recently introduced high-linearity tri-junction bi-SQUIDs (superconducting quantum interference device). Our bi-SQUID SQIF array design is based on a tight integration of individual bi-SQUID cells sharing inductances with adjacent cells. We provide extensive computer simulations, analysis, and experimental measurements, in which we explore the phase dynamics and linearity of the array voltage response. The nonuniformity in inductances of the bi-SQUIDs produces a pronounced zero-field single antipeak in the voltage response. The antipeak linearity and size can be optimized by varying the critical current of the additional junction of each bi-SQUID. The layout implementation of the tight 2-D array integration leads to a distinct geometrical diamond shape formed by the merged dual bi-SQUID cells. Different-sized 2-D arrays are fabricated using the standard HYPRES niobium 4.5 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> fabrication process. The measured linearity, power gain, and noise properties will be analyzed for different array sizes and the results will be compared with circuit simulations. We will discuss a design approach for the electrically small magnetic field antenna and low-noise amplifiers with high bandwidth based on these 2-D bi-SQUID SQIF arrays. The results from this work will be used to design chips densely and completely covered in bi-SQUIDs that have optimized parameters such as linearity and power gain.
Octave-band tunable (0.74-1.89 µm) optical vortex laser (2016)

We developed an octave-band tunable optical vortex laser based on a 0.532-μm optical vortex-pumped optical parametric oscillator with an extended cavity configuration by employing cascaded non-critical phase-matching LiB3O5 crystals. The optical vortex output was tuned within a wavelength range of 735nm-1893nm, and a pulse energy of 0.24-2.36 mJ was also achieved.
A CONVENIENT SYNTHESIS OF 3,3-DIMETHYLBUTYRALDEHYDE (2001)

3,3-Dimethylbutyraldehyde is synthesized from the reaction of 1-chloro-3,3-dimethylbutane with DMSO in presence of a base and substoichiometric amounts of MX (M = Na, K; X = Br, I).
Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor (2013)

The protein arginine deiminases (PADs) are a family of Ca2+-dependent enzymes that catalyze the conversion of peptidyl-arginine to peptidyl-citrulline in numerous protein substrates. Disruption of normal PAD activity plays a role in the pathogenesis of multiple inflammatory diseases such as rheumatoid arthritis (RA), chronic obstructive pulmonary disease, ulcerative colitis, multiple sclerosis, psoriasis, Alzheimer’s disease, and in various cancers. PAD inhibitors described in the literature have been useful chemical tools to study the role of PAD enzymes in inflammatory diseases and cancer biology. Most published PAD inhibitors are mechanism-based inactivators belonging to the halogen-amidine chemotype. For emerging targets such as the PADs, it can be difficult to distinguish compound-specific effects from those truly resulting from enzyme inhibition. We therefore initiated a fluorescence polarization activity-based protein profiling (fluopol-ABPP) high throughput screening (HTS) campaign to identify a second PAD inhibitor chemotype.The PAD4 HTS campaign identified the natural product streptonigrin (SID 11532976) as an irreversible PAD4-specific inhibitor. We describe herein the medicinal chemistry optimization of streptonigrin to the pan PAD probe ML325 (SID 118043677). ML325 inhibits PAD1, 2, 3, and 4 in vitro with IC50 values of 70 nM, 200 nM 170 nM, and 240 nM respectively. In a kinetic assay of inhibition more appropriate for irreversible inhibitors, ML325 has kinact/KI values of 3500, 7300, 1900, and 5300 M−1min−1 for PAD1, 2, 3 and 4 respectively; indicating it has less than 4-fold selectivity among the four family members. Despite its promiscuity within the PAD family, ML325 exhibits high selectivity vs. more than 20 cysteine-reactive proteins as assayed by activity-based protein profiling. ML325 was also demonstrated to inhibit all four PAD isozymes irreversibly and to be non-cytotoxic to NIH-3T3 cells. The complete properties, characterization, and synthesis of ML325 are detailed in this report.
Frequency-domain optical coherence tomography based on minimum-phase functions (2006)

We present a simple processing technique that uses the concept of minimum-phase functions to improve frequency-domain optical coherence tomography systems. Our novel approach removes the auto-correlation noise and therefore increases both the accessible depth range and the recovery accuracy. Furthermore it provides a better axial resolution. To our knowledge, this is the first time that the concept of minimum-phase functions has been applied to improve optical coherence tomography.
3D residual velocity analysis and update toolkit for offset‐domain prestack depth migration (2001)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 20013D residual velocity analysis and update toolkit for offset‐domain prestack depth migrationAuthors: Wei LiuDimitri BevcAlexander M. PopoviciBiondo BiondiWei Liu3DGeo Development Inc., Dimitri Bevc3DGeo Development Inc., Alexander M. Popovici3DGeo Development Inc., and Biondo BiondiStanford Universityhttps://doi.org/10.1190/1.1816789 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1816789FiguresReferencesRelatedDetailsCited byStudy and Application of Velocity Model Building Method for the Areas with Complicated Structures4 March 2017 SEG Technical Program Expanded Abstracts 2001ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2001 Pages: 2135 publication data© 2001 Copyright © 2001 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 03 Jan 2005 CITATION INFORMATION Wei Liu, Dimitri Bevc, Alexander M. Popovici, and Biondo Biondi, (2001), "3D residual velocity analysis and update toolkit for offset‐domain prestack depth migration," SEG Technical Program Expanded Abstracts : 925-928. https://doi.org/10.1190/1.1816789 Plain-Language Summary PDF DownloadLoading ...
Turbo receiver with SC/simplified-MMSE (S-MMSE) type equalizer for MIMO channel signal transmission (2003)

The paper proposes a novel turbo equalization method, called SC/simplified-MMSE (S-MMSE), for multiple-input multiple-output (MIMO) channel signal transmission. Turbo equalization is an iterative equalization and decoding process. Our method, which deals with residual inter sub stream interference as their average over a frame, achieves excellent error performance at small computational cost. We evaluate our method by link-level and system-level simulations. A complexity comparison is also presented.
The Preparation and Properties of meta-Carborane—Siloxane Elastomers (1975)

Abstract A new synthesis of D 2 -carborane—siloxanes is described which overcomes many of the disadvantages of previous synthetic methods. Linear polymers with molecular weights up to 250,000 can now be prepared using silanol-silylurea condensation reactions. Elastomers with useful general properties and good retention of mechanical properties after heat aging in air at 315°C for 300 hr were produced. The property profile and ease of vulcanization suggest utility in high-performance sealant, gasket, O-ring, and coating applications.
Molecular Characterization of a Metastatic Neuroendocrine Cell Cancer Arising in the Prostates of Transgenic Mice (2002)

The features and functions of prostatic neuroendocrine (NE) cells remain ill-defined. Neuroendocrine differentiation (NED) in adenocarcinoma of the human prostate (CaP) is associated with more aggressive disease, but the underlying mediators are poorly understood. We examined these issues in transgenic mice that utilize regulatory elements from the cryptdin-2 gene (Defcr2) to express simian virus 40 large T antigen (TAg) in prostatic NE cells. CR2-TAg mice develop prostatic intraepithelial neoplasia at 8 weeks of age, 1 week after the onset of TAg expression. An invasive phase follows 2-4 weeks later, with lymph node, liver, lung, brain, and bone metastases appearing within 16 weeks. DNA microarray studies revealed 122 mRNAs that were increased >/=2-fold in duplicate assays of 16-week-old CR2-TAg versus normal prostates. Thirty two transcripts encode proteins associated with neurons and endocrine cells (e.g. basic helix loop helix, SRY-related high mobility group box and sine-oculis homeobox transcription factors, Hu RNA-binding proteins, neuronatin, Racgap1, collapsin response mediator protein-1, synaptotagmin-1, proprotein convertase, and secretogranins). Follow-up studies of candidate mediators and biomarkers of differentiation/growth in the microarray data set involved real time quantitative reverse transcriptase-PCR assays of laser capture microdissected NE cells from CR2-TAg prostates plus liver metastases, and immunohistochemical comparisons of transgenic mouse prostates and 35 human CaP samples. Our findings include (a) expression of the bHLH mouse achaete-scute homolog (mASH1) in normal and CR2-TAg NE cells and foci of NED in human CaP, (b) glutamic acid decarboxylase and its product (gamma-aminobutyric acid) in neoplastic NE cells juxtaposed next to cohorts of normal gamma-aminobutyric acid receptor expressing secretory cells (a potential route for paracrine interactions between these two epithelial lineages), and (c) aromatic l-amino-acid decarboxylase, but not its dopamine/serotonin products, in CR2-TAg NE cells and NED. These results underscore the value of CR2-TAg mice for characterizing normal NE cell biology and tumorigenesis.
Ion-beam-textured graphite (1979)

Results of evaluation of seven different materials (copper, tantalum, titanium carbide, soot, smooth pyrolytic graphite, and ion-beam-textured graphite) for low secondary-electron emitting surface for depressed collects in microwave amplifiers indicate that ion-beam-textured graphite shows greatest potential for use.
ECT seizure therapeutic adequacy. (1994)

From the beginnings of convulsive therapy, the need for some way to assess the therapeutic adequacy of individual treatments has been apparent. Recent work suggests that seizure therapeutic adequacy and adverse effects are dependent on the extent to which the stimulus exceeds the seizure threshold (relative stimulus intensity). Applying this information in clinical practice is problematic because of the variable rise in the seizure threshold that takes place over the treatment course. Attributes of the ictal electroencephalogram (EEG) show promise for alleviating this problem by serving as a marker of relative stimulus intensity. Obstacles that need to be overcome in order to implement ictal EEG indices as a relative stimulus intensity marker in clinical practice are discussed and include artifacts, how to determine a threshold for deciding adequacy, variation in technique between sites, and inter-individual EEG variation; some strategies for overcoming these hurdles are described. It is anticipated that an ictal EEG algorithm that addresses these issues is likely to be of substantial clinical benefit in the practice of electroconvulsive therapy.
Ultrasonic Transducers for Medical Imaging (2006)

Abstract The performance of modern ultrasound imaging systems is primarily determined by the characteristics of the ultrasound transducer. Early imaging systems were based on single‐element transducers. These transducers had a fixed focal distance and had to be mechanically scanned to create an image. The systems were cumbersome to use, and the image quality was relatively poor. Much of the success of modern ultrasound imaging can be attributed to the development of efficient transducer arrays. The ultrasound beam produced by an array can be electronically steered and focused. Electronic steering avoids the need to mechanically scan the transducer, whereas electronic focusing provides improved resolution over a large imaging depth. Since transducer arrays were first introduced in the late 1970s, there has been a steady improvement in the efficiency and resolution of arrays. Transducer arrays are now available in a variety of geometries and operating frequencies, each optimized for a particular imaging application. As new transducer materials and improved fabrication techniques have become available, there has been a corresponding improvement in the quality of the ultrasound images. The pace of this development has not slowed, and improvements in ultrasound imaging can be expected for many years to come.
Stem Cell-Derived Microvesicles: A Cell Free Therapy Approach to the Regenerative Medicine (2012)

Microvesicles (MVs) include a heterogeneous population of vesicles released as exosomes from the endosomal compartment or as shedding vesicles from the cell surface of different cell types. The broad spectrum of biological activities displayed by MVs candidate them to a pivotal role in cell-to-cell communication. It is now recognized that they constitute an integral part of the intercellular microenvironment acting as vehicle for information transfer. After receptorligand interaction with target cells, MVs may directly stimulate the cells or may transfer from the cell of origin various bioactive molecules including membrane receptors, bioactive lipids and proteins. In addition, MVs may induce epigenetic changes in target cells by delivering specific subsets of mRNA and microRNA associated with different cell functions such as differentiation of blood cells, metabolic pathways and modulation of immune response. In vivo, MVs released from mesenchymal stem cells may account for the described paracrine action of these cells in tissue regeneration. A bidirectional exchange of genetic information between stem and injured cells could be envisaged: i) transcripts delivered by MVs from injured cells may reprogram the phenotype of stem cells to acquire specific features of the tissue; ii) transcripts delivered by MVs from stem cells may limit tissue injury and induce cell cycle re-entry of resident cells leading to tissue self-repair. This review presents an overview of the many biological actions of MVs produced by stem cells that may be exploited in regenerative medicine to repair damaged tissues as an alternative to stem cell-based therapy. Keywords: Angiogenesis, apoptosis, cell communication, exosomes, inflammation, kidney repair, mesenchymal stem cells, stem cells, microvesicles, transport of genetic information, liver repair, signal transduction, tissue regeneration, microRNA
Modifying Cochlear Implant Design: Advantages of Placing a Return Electrode in the Modiolus (2004)

Placing a cochlear implant's return electrode in the modiolus should significantly reduce its power consumption. Reducing power requirements should lead to improved efficiency, safer long-term use, and longer device life.
Frequency-dependent crosstalk simulation for on-chip interconnections (1999)

An extensive study of crosstalk simulation issues for on-chip interconnections was performed for representative six-layer Al(Cu) structures. Guidelines are given for the range of conditions when R(f)L(f)C versus RLC versus RC circuit representations are valid. Examples are also given of realistic short and long coupled-section interactions and the effect of in-plane neighboring connections is discussed. A frequency-dependent crosstalk simulation technique is shown. All simulation results are verified through measurement of a comprehensive set of experiments built with a large range of line widths and spaces on various layers with both in-plane and vertical coupling. Signal propagation and crosstalk are analyzed over the temperature range -160/spl deg/C to +100/spl deg/C and interconnect bandwidth limitations predictions are given.
Constant - Loss taper: design, simulation, and fabrication (2015)

Silicon - on - insulator (SOI) is a platform that possesses a large index of refraction layer of silicon (n~3.5) on top of an optically insulating buried oxide layer (n~1.46); strong light confinement can be achieved via the large refractive index contrast and it enables high-density optical circuitry. The modal area of a typical SOI waveguide is approximately 0.1 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (500 x 220 nm) which, is orders of magnitude smaller than a typical SMF-28 fiber, ~50 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (10.4 μm in modefield diameter); this large mismatch prohibits efficient light coupling from an external fiber to an integrated waveguide and requires the implementation of mode converters. This paper presents a novel approach to the design of inverse taper for mode conversion, shown is a comparative study between three types of tapers: linear, parabolic, and a novel constant-loss taper (CLT). The CLT is firstly derived using 3D coupled-mode theory and then simulated using 3D finite-difference time-domain simulations. It is demonstrated that a gain in efficiency of 5-20% can be achieved by using a CLT over a linear or parabolic taper for taper lengths ranging from 2 to 40 μm. Furthermore the CLT is shown to be more resilient to both fabrication errors and sidewall roughness than its linear or parabolic counterparts. In addition, our latest results from fabrication and testing will be presented.
ChemInform Abstract: 2‐ACETYLPYRIDINE THIOSEMICARBAZONES. 2. N4,N4‐DISUBSTITUTED DERIVATIVES AS POTENTIAL ANTIMALARIAL AGENTS (1980)

Abstract Nach verschiedenen Methoden werden die Thiosemicarbazone (I)‐(V) dargestellt.
Phase I-II trial of a novel mixed haptenized autologous melanoma vaccine (2004)

2563
Dynamic Hierarchical Markov Random Fields for Integrated Web Data Extraction (2008)

Existing template-independent web data extraction approaches adopt highly ineffective decoupled strategies—attempting to do data record detection and attribute labeling in two separate phases. In this paper, we propose an integrated web data extraction paradigm with hierarchical models. The proposed model is called Dynamic Hierarchical Markov Random Fields (DHMRFs). DHMRFs take structural uncertainty into consideration and define a joint distribution of both model structure and class labels. The joint distribution is an exponential family distribution. As a conditional model, DHMRFs relax the independence assumption as made in directed models. Since exact inference is intractable, a variational method is developed to learn the model’s parameters and to find the MAP model structure and label assignments. We apply DHMRFs to a real-world web data extraction task. Experimental results show that: (1) integrated web data extraction models can achieve significant improvements on both record detection and attribute labeling compared to decoupled models; (2) in diverse web data extraction DHMRFs can potentially address the blocky artifact issue which is suffered by fixed-structured hierarchical models.
Articulated robotic scanner for mine detection: a novel approach to vehicle-mounted systems (1999)

Conventional vehicle-mounted mine detector system employ an array of sensor elements to achieve a detection swath. Some systems employ more than one type of sensor technology. These systems, while being very useful, are often expensive, complex and inflexible. A human operator, on the other hand, sweeps a mine detector from side to side while moving forward to cover ground. The operator can follow the ground profile with the detector head close to the ground without hitting the ground or any objects on it. She can also vary the width of sweep to suit a particular situation, and is usually not limited by terrain. In this paper we present the concept and early prototype of a system that incorporates the advantages of the two methods described above while minimizing the disadvantages of both. For example, it will have the flexibility of a manual system with the rapid and safer mechanized scanning of the vehicle-mounted system but at a reduced cost, size and overall system complexity, when compared to existing approaches. Our approach uses an articulated robotic device capable of automatically moving mine detection sensor over natural ground surfaces including roads and tracks in a manner similar to a human operator. The system can also easily be used to place a confirmatory point sensor at a specific location if needed. The early prototype, which incorporates only a metal detector for a mine sensor, implements ground following by using a laser range finder and four ultrasonic sensors.
<title>Multi-axis whole-spacecraft vibration isolation for small launch vehicles</title> (2001)

Small launch vehicles present an economically viable method for placing small satellites into orbit. These launch vehicles would be even more attractive to satellite customers if they could provide a softer ride to orbit. Passive whole-spacecraft vibration isolation systems have been developed for small launch vehicles to greatly reduce the dynamic launch loads. To date, two types of isolation systems have been designed.
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys (2020)

Effective delivery of protein therapeutics to the central nervous system (CNS) has been greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB transport vehicle (TV) comprising an engineered Fc fragment that exploits receptor-mediated transcytosis for CNS delivery of biotherapeutics by binding a highly expressed brain endothelial cell target. TVs were engineered using directed evolution to bind the apical domain of the human transferrin receptor (hTfR) without the use of amino acid insertions, deletions, or unnatural appendages. A crystal structure of the TV-TfR complex revealed the TV binding site to be away from transferrin and FcRn binding sites, which was further confirmed experimentally in vitro and in vivo. Recombinant expression of TVs fused to anti-β-secretase (BACE1) Fabs yielded antibody transport vehicle (ATV) molecules with native immunoglobulin G (IgG) structure and stability. Peripheral administration of anti-BACE1 ATVs to hTfR-engineered mice and cynomolgus monkeys resulted in substantially improved CNS uptake and sustained pharmacodynamic responses. The TV platform readily accommodates numerous additional configurations, including bispecific antibodies and protein fusions, yielding a highly modular CNS delivery platform.
Maintenance of Long-Term Safety and Efficacy of Cannabidiol (CBD) Treatment in Dravet Syndrome (DS): Results of the Open-Label Extension (OLE) Trial (GWPCARE5) (S19.003) (2018)

Assess long-term safety and efficacy of CBD as add-on to existing antiepileptic drug (AED) treatment in patients with treatment-resistant DS.
Peptide inhibition of human cytomegalovirus infection (2011)

Peptides designed to target putative fusogenic domains of gB provide a basis for the development of novel therapeutics that prevent HCMV infection.
In-situ characterizations of dense non-aqueous phase liquids using partitioning tracers. Annual progress report, September 15, 1996--September 14, 1997 (1998)

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