gebhart/patrepeval huggingface dataset:
A Data Access Method in Mobile Computing Environment: Using Data Prefetch Technology in Parallel Control System Architecture (2006)

In mobile computing environment, the communication is asymmetric, the link is broken off frequently, and the user access patterns are diverse. In this paper, we focus on how to get the data which the user concerned effectively, and instantly. In the paper, a method, which using data prefetch technology in parallel control system architecture, is proposed. Experiments results show that the performance of data access is enhanced. Compared with existing methods, the method enhanced the performance in terms of average time of data access and satisfied requirements of instant data access
Signals mediating nuclear targeting and their regulation: Application in drug delivery (1998)

The recent progress with respect to understanding the signals mediating the transport of proteins in both directions through the NPC, and cellular proteins interacting with these signals to effect the transport process has made possible a number of advances in terms of the use of this information in a clinical setting. In particular, our knowledge of the mechanism of regulation of the process, and of how we may exploit the cellular transport machinery itself in a therapeutic situation, especially where there may be transport pathways specific to particular viruses, has advanced considerably. In this context, this review expounds current understanding of the signals conferring targeting to the nucleus, and their practical and potential use in delivering molecules of interest to the nucleus in a clinical context. It also deals with targeting signals conferring nuclear protein export/ shuttling between nuclear and cytoplasmic compartments as well as with those conferring nuclear or cytoplasmic retention, and with the specific mechanisms regulating the activity of these signals, and in particular those regulating signal-dependent nuclear protein import. Detailed understanding of the processes of signal-mediated nuclear protein import/export and its regulation enables the considered application and optimization of approaches to target molecules of interest, such as plasmid DNA or toxic molecules, efficiently to the nucleus according to need in a clinical or research context, and enhance the expression or efficiency of their action, respectively. The use of nuclear targeting signals in this context is reviewed, and future possibilities in terms of the application of our growing understanding of nuclear transport and its regulation are discussed.
A context-related authorization and access control method based on RBAC: (2002)

This paper describes an application of authorization and access control based on the Role Based Access Control (RBAC) method and integrated in a comprehensive trust infrastructure of a health care application. The method is applied to a health care business process that involves multiple actors accessing data and resources needed for performing clinical and logistics tasks in the application. The notion of trust constituency is introduced as a concept for describing the context of authorisation. In addition, the applied RBAC covers time constraints, hierarchies and multi-level authorization rules for coping with the multi-actor nature and the complexity of the application domain. The DRIVE RBAC model clearly distinguishes between static role assignment to users and dynamic allocation of roles at session time. The paper, while focusing on the authorization and access control approach, also describes how the RBAC functions have been integrated in a trust infrastructure including smart cards.
Snoring and breathing pauses during sleep: telephone interview survey of a United Kingdom population sample (1997)

Disordered breathing during sleep is widely underdiagnosed in the United Kingdom. The condition is linked to increased use of medical resources and a greater risk of daytime sleepiness, which augments the risk of accidents. Doctors should ask patients and bed partners regularly about snoring and breathing pauses during sleep.
The Effects of Cholera Toxin on Cellular Energy Metabolism (2010)

Multianalyte microphysiometry, a real-time instrument for simultaneous measurement of metabolic analytes in a microfluidic environment, was used to explore the effects of cholera toxin (CTx). Upon exposure of CTx to PC-12 cells, anaerobic respiration was triggered, measured as increases in acid and lactate production and a decrease in the oxygen uptake. We believe the responses observed are due to a CTx-induced activation of adenylate cyclase, increasing cAMP production and resulting in a switch to anaerobic respiration. Inhibitors (H-89, brefeldin A) and stimulators (forskolin) of cAMP were employed to modulate the CTx-induced cAMP responses. The results of this study show the utility of multianalyte microphysiometry to quantitatively determine the dynamic metabolic effects of toxins and affected pathways.
Chemical Pinching of Azalea with Dikegulac1 (1976)

Abstract Foliar application of 0.4 to 0.6% of an aqueous solution of sodium 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonate) (dikegulac, Atrinal) was effective as a pinching agent under commercial growing conditions on all azalea ( Rhododenron simsii Planch.) cultivars tested. One to 2 weeks after application the upper leaves turned yellow. Within 4 weeks after treatment the axillary shoots began to elongate and 4-8 weeks later the foliage regained a dark green color. Reproductive shoots treated with dikegulac produced new axillary shoots, but treatment should precede flower initiation for optimal results. At all dosage rates a better pinching effect was obtained with higher spray volumes. A spray volume of 200-300 ml/m 2 (2-3 qts/100 ft 2 ), depending on growth stage, is suggested. Dikegulac is a very promising chemical pinching agent for greenhouse azaleas.
Advances in the topical treatment of acne and rosacea. (2005)

Acne and rosacea are common skin diseases which may present similarly and both involve inflammation. Both can result in significant cosmetic impairment and lead to quality of life decrements if not optimally treated. The conventional approach for both diseases involves the use of topical therapy to treat inflammatory lesions in combination, when needed, with a systemic or topical antibiotic. An important issue in the management of both diseases at present is the need to reduce antibiotic usage due to the increasing problem of bacterial resistance. One of the emerging treatment paradigms that is becoming increasingly useful as an antibiotic-sparing strategy is the use of procedural therapies in combination with medical management. Such procedural modalities include lasers, intense pulsed light (IPL), and photodynamic therapies (PDT). Topical regimens are used pre-treatment and following physical modalities for maintenance of remission.
An Electret Passive Environmental 222Rn Monitor Based on Ionization Measurement (1988)

The electret passive environmental 222Rn monitor (E-PERM) is an extension of electret dosimeters used for measurement of x and gamma radiation. An E-PERM consists of a small cup or canister, having an electret at the bottom, and a filtered inlet at the top. The 222Rn gas entering through the filter and the decay products formed inside the cup generate ions which are collected by the electret. The reduction of charge (or surface potential) on the electret is a measure of time integrated 222Rn exposure. An E-PERM of 220-mL volume with an electret of 0.23 cm thickness gave a surface potential drop of 2.5 V for 37 Bq m-3 d (1 pCi L-1 d). The electret voltage was measured with a specially built surface potential voltmeter. This sensitivity was found adequate for a 1-wk measurement of 222Rn in homes. For longer term measurements, an E-PERM of 40-mL volume and an electret of 51-micron thickness was developed which gave a surface potential drop of 2.6 V for 37 Bq m-3 y (1 pCi L-1 y). Other combinations of chamber volume and electret thicknesses gave responses between these two values. The surface potential of electrets made from Teflon FEP were shown to stay stable even under extreme conditions of relative humidity. The ion collection process in E-PERMs was also shown to be independent of humidity down to an electret surface potential of 100 V.
Epigenetic signature and enhancer activity of the human APOE gene (2013)

The human apolipoprotein E (APOE) gene plays an important role in lipid metabolism. It has three common genetic variants, alleles ε2/ε3/ε4, which translate into three protein isoforms of apoE2, E3 and E4. These isoforms can differentially influence total serum cholesterol levels; therefore, APOE has been linked with cardiovascular disease. Additionally, its ε4 allele is strongly associated with the risk of Alzheimer's disease (AD), whereas the ε2 allele appears to have a modest protective effect for AD. Despite decades of research having illuminated multiple functional differences among the three apoE isoforms, the precise mechanisms through which different APOE alleles modify diseases risk remain incompletely understood. In this study, we examined the genomic structure of APOE in search for properties that may contribute novel biological consequences to the risk of disease. We identify one such element in the ε2/ε3/ε4 allele-carrying 3'-exon of APOE. We show that this exon is imbedded in a well-defined CpG island (CGI) that is highly methylated in the human postmortem brain. We demonstrate that this APOE CGI exhibits transcriptional enhancer/silencer activity. We provide evidence that this APOE CGI differentially modulates expression of genes at the APOE locus in a cell type-, DNA methylation- and ε2/ε3/ε4 allele-specific manner. These findings implicate a novel functional role for a 3'-exon CGI and support a modified mechanism of action for APOE in disease risk, involving not only the protein isoforms but also an epigenetically regulated transcriptional program at the APOE locus driven by the APOE CGI.
An ocean of opportunity (2019)

Charlotte Wake explains why postgraduate courses not only broaden horizons but also prove refreshingly fruitful, too!
PENGARUH TAX AVOIDANCE TERHADAP NILAI PERUSAHAAN DENGAN TRANSPARANSI SEBAGAI VARIABEL MODERASI (2023)

Penelitian ini menguji pengaruh profitabilitas dan ukuran perusahaan terhadap nilai perusahaan farmasi yang terdaftar di Bursa Efek Indonesia Tahun 2016-2020. Penelitian ini menggunakan metode kuantitatif dan data sekunder. Metode pengambilan sampel menggunakan purposive sampling dan diperoleh 9 perusahaan selama 5 tahun. Teknik analisis yang digunakan adalah regresi data panel dengan menggunakan aplikasi pengolahan data Eviews 10 untuk memperoleh gambaran secara menyeluruh terkait hubungan antara variabel satu dengan variabel lainnya. Hasil penelitian menunjukkan bahwa profitabilitas berpengaruh positif signifikan terhadap nilai perusahaan dan ukuran perusahaan berpengaruh positif signifikan terhadap nilai perusahaan.
Better Algorithms to Minimize the Cost of Test Paths (2012)

Model-based testing creates tests from abstract models of the software. These models are often described as graphs, and test requirements are defined as sub paths in the graphs. As a step toward creating concrete tests, complete (test) paths that include the sub paths through the graph are generated. Each test path is then transformed into a test. If we can generate fewer and shorter test paths, the cost of testing can be reduced. The minimum cost test paths problem is finding the test paths that satisfy all test requirements with the minimum cost. This paper presents new algorithms to solve the problem, and then presents data from an empirical comparison. The algorithms adapt approximation algorithms for the shortest super string problem. The comparison is with an existing tool that uses a brute force approach to extend each sub path to a complete path. One new algorithm is based on the greedy set-covering algorithm and the other is based on finding a matching over a prefix graph. The comparison was performed on open software and showed that both new solutions generate fewer test paths than the brute force approach. The prefix-graph based solution takes much less time than the other two solutions when the number of test requirements is large.
An Improved Method for Product Separation in Metathetical Reactions and its Demonstration for the Synthesis of Anhydrous Cesium Salts (2002)

In conventional metathetical reactions, product separation is based on solubility product differences, and the resulting products are often impure and require purification by recrystallization. A new approach to product separation is described that relies on the formation of an unstable, volatile by-product, such as NH4+CH3O—. This method provides very pure and anhydrous products in high yield and was demonstrated successfully for the syntheses of anhydrous cesium salts.
Staphylococcus epidermidis and retention of neonatal percutaneous central venous catheters. (1990)

The percutaneous insertion of central venous catheters has become an established practice on many neonatal units. We describe four low birthweight babies, whose catheters became tethered in the vein, and discuss the management of this unusual complication.
Three new nuclear genes, <i>sigD</i>, <i>sigE</i> and <i>sigF</i>, encoding putative plastid RNA polymerase σ factors in <i>Arabidopsis thaliana</i> (2000)

Three new nuclear genes (sigD, sigE and sigF) of Arabidopsis thaliana, encoding putative plastid RNA polymerase sigma factors, were identified and analyzed. Phylogenetic analysis revealed that higher plant sigma factors fell into at least four distinct subgroups within a diverse protein family. In addition, Arabidopsis sig genes contained conserved chromosomal intron sites, indicating that these genes arose by DNA duplication events during plant evolution. Transcript analyses revealed two alternatively spliced transcripts generated from the sigD region, one of which is predicted to encode a sigma protein lacking the carboxy-terminal regions 3 and 4. Finally, the amino-terminal sequence of the sigF gene product was shown to function as a plastid-targeting signal using green fluorescent protein fusions.
A Distributed Interdomain Control System for Information-Centric Content Delivery (2018)

The Internet, the de facto platform for large-scale content distribution, suffers from two issues that limit its manageability, efficiency, and evolution. First, the IP-based Internet is host-centric and agnostic to the content being delivered and, second, the tight coupling of the control and data planes restrict its manageability, and subsequently the possibility to create dynamic alternative paths for efficient content delivery. Here, we present the CURLING system that leverages the emerging Information-Centric Networking paradigm for enabling cost-efficient Internet-scale content delivery by exploiting multicasting and in-network caching. Following the software-defined networking concept that decouples the control and data planes, CURLING adopts an interdomain hop-by-hop content resolution mechanism that allows network operators to dynamically enforce/change their network policies in locating content sources and optimizing content delivery paths. Content publishers and consumers may also control content access according to their preferences. Based on both analytical modeling and simulations using real domain-level Internet subtopologies, we demonstrate how CURLING supports efficient Internet-scale content delivery without the necessity for radical changes to the current Internet.
Prophylactic drugs in the management of childhood asthma. (1979)

Recurrences of explosive, severe asthma in children can often be prevented by immunotherapy and constant surveillance of environmental and dietary control. In addition, judicious and preserving use of pharmaceuticals may be employed for prophylaxis in childhood asthma. These include cromolyn sodium by inhalation, beclomethasone dipropionate aerosols, round-the-clock methylxanthines and beta 2 adrenergic bronchodilator agents. Their application is discussed.
Correlation-Aware Object Placement for Multi-Object Operations (2008)

A multi-object operation incurs communication or synchronization overhead when the requested objects are distributed over different nodes. The object pair correlations (the probability for a pair of objects to be requested together in an operation) are often highly skewed and yet stable over time for real-world distributed applications. Thus, placing strongly correlated objects on the same node (subject to node space constraint) tends to reduce communication overhead for multi-object operations. This paper studies the optimization of correlation-aware data placement. First, we formalize a restricted form of the problem as a variant of the classic Quadratic Assignment problem and we show that it is NP-hard. Based on a linear programming relaxation, we then propose a polynomial-time approximation algorithm that finds an object placement with communication overhead at most two times that of the optimal placement. We further show that the computation cost can be reduced by limiting the optimization scope to a relatively small number of most important objects. We quantitatively evaluate our approach on keyword index placement for full-text search engines using real traces of 3.7 million web pages and 6.8 million search queries. Compared to the correlation-oblivious random object placement, our approach achieves 37-86% communication overhead reduction on a range of optimization scopes and system sizes. The communication reduction is 30-78% compared to a correlation-aware greedy approach.
Youth Unemployment and State Intervention (2022)

Within the context of worsening employment, the particular plight of young people has been identified as a subject for special concern. The Manpower Services Commission (MSC), set up in 1974 to foster training and employment services, has grown enormously as a state agency, particularly in the area of providing special temporary measures to combat unemployment - and most of these have been directed towards young people. Young people are always particularly vulnerable to unemployment in a recession, largely due to cuts in recruitment. Changes in the industrial structure of employment over the last decade have exacerbated the problem, rendering young people’s employment prospects particularly bleak. In the early days of MSC’s operations, it perceived its role as helping young people to overcome the disadvantage they suffered in competing for jobs with older workers - lack of experience.
Literature and forgetting (1991)

In February 1948, Communist leader Klement Gottwald stepped out on the balcony of a Baroque palace in Prague to address the hundreds of thousands of his fellow citizens packed into Old Town Square. It was a crucial moment in Czech history - a fateful moment of the kind that occurs once or twice in a millennium...
Diagnostic patch test concentration for Kathon CG (1985)

Patch test studies, 21-day cumulative irritancy assays and Draize repeat insult patch tests with Kathon CG, were used to ascertain an appropriate diagnostic patch test concentration. A dilution of 100 ppm a.i. (aq. or pet.) appears to have low irritancy potential. Further observations are required to verify if this concentration is high enough to detect most cases of sensitization.
Diversity and specialization of mammalian SWI/SNF complexes. (1996)

The SWI/SNF complex in yeast facilitates the function of transcriptional activators by opposing chromatin-dependent repression of transcription. We demonstrate that in mammals SWI/SNF complexes are present in multiple forms made up of 9-12 proteins that we refer to as BRG1-associated factors (BAFs) ranging from 47 to 250 kD. We have isolated cDNAs for human BAF155, BAF170, and BAF60. BAF155 and BAF170 are encoded by separate genes that are both homologs of yeast SWI3. Both contain a region of similarity to the DNA binding domain of myb, but lack the basic residues known to be necessary for interaction with DNA. The two SWI3 homologs copurify on antibody columns specific for either BAF155 or BAF170, indicating that they are in the same complex. BAF60 is encoded by a novel gene family. An open reading frame from yeast, which is highly homologous, encodes the previously uncharacterized 73-kD subunit of the yeast SWI/SNF complex required for transcriptional activation by the glucocorticoid receptor (Cairns et al., this issue). BAF60a is expressed in all tissues examined, whereas BAF60b and BAF60c are expressed preferentially in muscle and pancreas, respectively. BAF60a is present within the 2000-kD BRG1 complex, whereas BAF60b is in a distinct complex that shares some but not all subunits with the BRG1 complex. The observed similarity between mammalian BAF190, BAF170, BAF155, BAF60, and BAF47 and yeast SNF2/SWI2, SWI3, SWI3, SWP73, and SNF5, respectively, underscores the similarity of the mammalian and yeast complexes. However, the complexes in mammals are more diverse than the SWI/SNF complex in yeast and are likely dedicated to developmentally distinct functions.
A Gender Mixture Detection Approach to Unsupervised Single-Channel Speech Separation Based on Deep Neural Networks (2017)

We propose an unsupervised speech separation framework for mixtures of two unseen speakers in a single-channel setting based on deep neural networks (DNNs). We rely on a key assumption that two speakers could be well segregated if they are not too similar to each other. A dissimilarity measure between two speakers is first proposed to characterize the separation ability between competing speakers. We then show that speakers with the same or different genders can often be separated if two speaker clusters, with large enough distances between them, for each gender group could be established, resulting in four speaker clusters. Next, a DNN-based gender mixture detection algorithm is proposed to determine whether the two speakers in the mixture are females, males, or from different genders. This detector is based on a newly proposed DNN architecture with four outputs, two of them representing the female speaker clusters and the other two characterizing the male groups. Finally, we propose to construct three independent speech separation DNN systems, one for each of the female-female, male-male, and female-male mixture situations. Each DNN gives dual outputs, one representing the target speaker group and the other characterizing the interfering speaker cluster. Trained and tested on the speech separation challenge corpus, our experimental results indicate that the proposed DNN-based approach achieves large performance gains over the state-of-the-art unsupervised techniques without using any specific knowledge about the mixed target and interfering speakers being segregated.
Elastic Cuckoo Page Tables (2020)

The unprecedented growth in the memory needs of emerging memory-intensive workloads has made virtual memory translation a major performance bottleneck. To address this problem, this paper introduces Elastic Cuckoo Page Tables, a novel page table design that transforms the sequential pointer-chasing operation used by conventional multi-level radix page tables into fully-parallel look-ups. The resulting design harvests, for the first time, the benefits of memory level parallelism for address translation. Elastic cuckoo page tables use Elastic Cuckoo Hashing, a novel extension of cuckoo hashing that supports efficient page table resizing. Elastic cuckoo page tables efficiently resolve hash collisions, provide process-private page tables, support multiple page sizes and page sharing among processes, and dynamically adapt page table sizes to meet application requirements. We evaluate elastic cuckoo page tables with full-system simulations of an 8-core processor using a set of graph analytics, bioinformatics, HPC, and system workloads. Elastic cuckoo page tables reduce the address translation overhead by an average of 41% over conventional radix page tables. The result is a 3-18% speed-up in application execution.