gebhart/patrepeval huggingface dataset:
Changes of D-dimer,P-selectin and von willebrand factor in ovarian cysts perioperative (2013)

Objective To investigate the ovarian cysts perioperative on D-dimer,P-selectin,von Willebrand factor changes,provide the basis for the prevention venous thromboembolic complications after laparoscopic surgery.Methods Sixty cases of ovarian cysts need surgical treatment were divided into the laparoscopy group (n=39) and laparotomy group(n =21) according to their wishes.All patients to check the D-dimer,P-selectin and VWF concentration before surgery,10 min after surgery,postoperative 24 hours.Study the blood coagulation before and after the gynecological laparoscopic surgery,and to compare laparoscopic and open surgery on the patients' blood coagulation.Results Laparoscopic group after l0 min and 24 h after surgery,plasma D-dimer,P-selectin and VWF concentrations were higher than preoperative levels,the changes were significant differences (P ＜ 0.05) ; Ten minutes after the end of the surgery,plasma D-dimer,P-factors and VWF concentrations in laparotomy group were higher than preoperative levels (P ＜ O.05),but after 24 h,the difference was not statistically significant.Conclusions Postoperative plasma D-dimer,P-factors and VWF concentration in the laparoscopic group were higher than those in the laparotomy group,laparoscopic group decreased slightly faster than the laparotomy group after 24 h,suggesting that laparoscopic surgery does not increase the thrombosisthe incidence of disease.

Key words: 
Ovarian cysts ;  D-dimer ;  P-selectin ;  Von Willebrand factor
Accuracy and linearity of time-domain THz paint thickness measurements (2008)

An analysis of the single point reproducibility of TD-THz based paint thickness measurements demonstrated a precision of 130 nm, corresponding to 0.1% of the measured thickness. A detailed model of the anticipated TD-THz waveforms from samples of varying thickness indicates that an intrinsic uncertainty of 0.09% is anticipated in the absence of environmental fluctuations. Therefore, the influence of oscillations in the THz field associated with the initial reflection does not adversely impact the ability to extract accurate paint thickness information, and the noise associated with these oscillations could limit the measurement uncertainty of a calibrated instrument under optimum laboratory conditions. In the case of a deployed sensor, we anticipate that the accuracy will be degraded by environmental fluctuations.
Rfx2 Stabilizes Foxj1 Binding at Chromatin Loops to Enable Multiciliated Cell Gene Expression (2017)

Cooperative transcription factor binding at cis-regulatory sites in the genome drives robust eukaryotic gene expression, and many such sites must be coordinated to produce coherent transcriptional programs. The transcriptional program leading to motile cilia formation requires members of the DNA-binding forkhead (Fox) and Rfx transcription factor families and these factors co-localize to cilia gene promoters, but it is not clear how many cilia genes are regulated by these two factors, whether these factors act directly or indirectly, or how these factors act with specificity in the context of a 3-dimensional genome. Here, we use genome-wide approaches to show that cilia genes reside at the boundaries of topological domains and that these areas have low enhancer density. We show that the transcription factors Foxj1 and Rfx2 binding occurs in the promoters of more cilia genes than other known cilia transcription factors and that while Rfx2 binds directly to promoters and enhancers equally, Foxj1 prefers direct binding to enhancers and is stabilized at promoters by Rfx2. Finally, we show that Rfx2 and Foxj1 lie at the anchor endpoints of chromatin loops, suggesting that target genes are activated when Foxj1 bound at distal sites is recruited via a loop created by Rfx2 binding at both sites. We speculate that the primary function of Rfx2 is to stabilize distal enhancers with proximal promoters by operating as a scaffolding factor, bringing key regulatory domains bound by Foxj1 into close physical proximity and enabling coordinated cilia gene expression.
Radiation Tolerant 6.25 Gbps 850nm Optical Transceiver (2017)

The key element of the next generation high-speed intra-satellite serial data communication link are the optical transceivers. Not only should these meet the high-reliability requirement for space with regard to thermal vacuum, mechanical vibration and shock, but also survive reliably in a radiation environment. At VTT the SolidOpto SPFI-(003)-6G 6.25 Gbps optical transceiver has been specifically engineered for this space environment. This device has successfully passed mechanical vibration and shock, thermal vacuum and total dose radiation up to 100krad. The first SEE radiation tests on this device have been performed and are the topic of this paper. The radiation tests demonstrate that this device is free of destructive radiation events. With a dedicated state-of-the-art high-speed radiation test set-up the BER as well as the SET rate as function of LET and flux could be determined for the optical transceiver operating at 5Gbps. Threshold and cross-section both for receiver and transmitter could be determined as well as the SET pulse-width distribution. The analysis of these results allows the predicted performance of this optical transceiver in space as a function of the implemented transmitted data encoding. Furthermore the result of this work demonstrates the viability of the operational use in space of the VTT SolidOpto SPFI(003)-6G 6.25 Gbps optical transceiver as one of the first of the devices of its kind.
Nucleoside Analogs: Similarities and Differences (1993)

Among the steps in the replication cycle of human immunodeficiency virus (HIV) that are potential targets for antiviral chemotherapy, the viral DNA polymerase or reverse transcriptase has been a target of choice in research on anti-HIV drugs. Nucleoside analogs--the agents studied in relation to this target--have no intrinsic activity against HIV and must be metabolized to their respective 5'-triphosphates by means of kinases, nucleotidases, or other activating enzymes present naturally in cells. The presence and activity of the intracellular enzymes necessary for activation of nucleoside analogs are highly dependent on host species, cell type, and stage in the cell cycle. A great advantage of 2',3'-dideoxynucleosides is their intracellular pharmacokinetic profile. The multifactorial mechanisms of toxicity associated with this class of drugs likely explain the different spectra of toxicity observed with the various individual nucleoside analogs and exemplify the uniqueness of each compound. Recently, strains of HIV resistant to 3'-azido-3'-deoxythymidine (zidovudine) were isolated from patients who had been treated with this drug; this resistance probably reflects sequential acquisition of amino acid mutations in the HIV reverse transcriptase.
UNIX Time-Sharing System: Language Development Tools (1978)

The development of new programs on the UNIX∗ system is facilitated by tools for language design and implementation. These are frequently program generators, compiling into C, which provide advanced algorithms in a convenient form, while not restraining the user to a preconceived set of jobs. Two of the most important such tools are Yacc, a generator of LALR(1) parsers, and Lex, a generator of regular expression recognizers using deterministic finite automata. They have been used in a wide variety of applications, including compilers, desk calculators, typesetting languages, and pattern processors.
Highly Reactive, General, and Long‐Lived Catalysts for Coupling Heteroaryl and Aryl Chlorides with Primary Nitrogen Nucleophiles (2005)

Resisting pathways for decomposition followed by palladium complexes of monodentate ligands is one characteristic of the highly reactive but long-lived catalyst generated from the Josiphos ligand L and palladium. It catalyzes under mild conditions the coupling of primary amines with chloropyridines and chloroarenes in high yield with low catalyst loadings (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462629_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The estimation of pitch angle in pitch-controlled wind turbine (2008)

According with control theory of variable-speed and constant-frequency (VSCF) pitch-controlled wind turbine, neural network algorithm is adopted to predict pitch angle at real-time working condition, and to obtain more accurate pitch angle reference value. It enhances control precision of the entire pitch-controlled system.
Enantioselektive Palladium‐katalysierte decarboxylierende allylische Alkylierungen (2006)

Dreifach A: Jüngste Entwicklungen bei Palladium-katalysierten decarboxylierenden asymmetrischen allylischen Alkylierungen (AAA) ermöglichen einen leichten Zugang zu hoch enantiomerenangereicherten Ketonen mit α-ständigen quartären oder tertiären Stereozentren unter milden Reaktionsbedingungen.
Integration of continuous speech recognition and information retrieval for mutually optimal performance (1999)

Traditionally, indexing and searching of speech content in multimedia databases have been achieved through a combination of separately constructed speech recognition and information retrieval engines. Although each technology has a legacy of research, only recently have efforts been made to study the potential suboptimality of this strategy, and none of these efforts specifically addresses the presence of uncertainty in automatically generated transcriptions. This research develops a refinement of the most common information retrieval relevance formula, TFIDF, to incorporate uncertainty as a retrieval feature, along with a set of techniques to acquire this uncertainty from multiple hypotheses produced by existing speech recognition data structures. In the process a greater amount of evidence is extracted than is available in the most likely transcription hypothesis, and overall retrieval precision and recall are improved. The term weighting scheme known as the inverse document frequenc...
Donor‐Substituted Heptaazaphenalene as a Nonlinear Optically Active Molecule with Multiple Charge‐Transfer Transitions (2004)

Abstract The synthesis of a novel nonlinear optical (NLO) chromophore with threefold symmetry − 2,5,8‐tris(diethylamino)‐1,3,4,6,7,9,9b‐heptaazaphenalene ( 4 ) − is reported. Compound 4 was synthesized from 2,5,8‐trichloro‐1,3,4,6,7,9,9b‐heptaazaphenalene ( 3 ) through a nucleophilic aromatic substitution, its structural assignment was confirmed by X‐ray investigations, and its second‐order polarisability (β) was determined by hyper Rayleigh scattering (HRS). Compound 4 shows a very high absorbance coefficient in the UV and a remarkably large β value despite its short‐wavelength absorption. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease (2017)

Chronic inflammation represents one of the most consistent biologic features of aging. However, the precise etiology of persistent low-grade increases in inflammation remains unclear. Recent evidence suggests that the gut microbiome may play a key role in age-related inflammation. Indeed, several studies have indicated that older adults display an altered composition of the gut microbiota, and early evidence indicates that this dysbiosis is associated with the presence of several key circulating inflammatory analytes. The present review summarizes knowledge on age-related inflammation and discusses how potential relationships with gut dysbiosis may lead to novel treatment strategies in the future."The pattern of disease is an expression of the response of man to his total environment (physical, biological, and social); this response is, therefore, determined by anything that affects man himself or his environment." - Rene Dubos, 1961.
New Virus-Selective Inhibitor of Terminal Glycosylation Increasing Immunological Reactivity of a Viral Glycoprotein (1990)

In previous reports we have shown that certain nucleoside analogues may be phosphorylated by herpesvirus-specified thymidine kinases, thereby acquiring an ability to act as virus-selective inhibitors of terminal glycosylation. In the present paper we report that the antiviral nucleoside analogue 5-propyl-2′-deoxyuridine induced a pattern of glycosylation inhibition, which resulted in an increased availability of the HSV-1-specified glycoprotein gC-1 for neutralizing antibodies. This effect, which was absent in cells infected with a thymidine kinase-deficient HSV mutant, was correlated with a decrease in the proportion of highly branched N-linked oligosaccharides associated with gC-1.
The Chemistry of 2‐Alkenyl‐5(4H)‐ oxazolones. IX. Acid‐Catalyzed Oligomerization (2003)

Abstract Results of the acid catalyzed oligomerization of 2‐alkenyl‐5(4H)‐oxazolones are reported. Employing LC–MS and preparative LC methods, the oligomeric mixtures were characterized by NMR analyses and were discovered to consist of exclusively cyclic trimers to decamers, with tetramers and pentamers predominating. A nucleophilic oligomerization mechanism involving Michael addition and C‐alkylation of a ketene‐aminal to protonated monomer was proposed that resulted in irreversible cyclization at the trimer propagation stage. Subsequent oligomerization proceeded via enolization of α‐hydrogens on 2‐substituted 5(4H)‐oxazolone products and continued Michael addition to protonated monomer. In the sense that when both enolizable hydrogens and protonated monomer are present, the oligomerization can be regarded as being “living.”
16. Co-Ownership (2020)

This chapter studies the trust of land, and how this legal structure is used to manage co-ownership of land. It first describes the nature of interests under a trust of land, and the rights and obligations for trustees and beneficiaries which arise as a result of the creation of such a trust. The chapter then details the different forms of concurrent co-ownership which can exist in relation to land, looking at joint tenancies and tenancy in common as well as the process of severance. Since co-ownership cannot exist without a trust, it is useful to have understood trusts generally before examining it as a tool to manage co-ownership situations. Finally, the chapter assesses the regulation of disputes between trustees, beneficiaries, and third parties. Partly these disputes relate to questions of priority, and so it is useful to read this chapter in conjunction with the previous one concerning the general priority rules.
Semidry and Dry Fermented Sausages (2010)

This chapter contains sections titled: Introduction Fermented Sausage Classification Fermented Sausage Manufacture Types of Semidry and Dry Fermented Sausages Worldwide Safety of Semidry and Dry Fermented Sausages Trends in Fermented Sausage Production References
Polysulfone ultrafiltration membranes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolysulfone ultrafiltration membranesT. A. Tweddle, O. Kutowy, W. L. Thayer, and S. SourirajanCite this: Ind. Eng. Chem. Prod. Res. Dev. 1983, 22, 2, 320–326Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://pubs.acs.org/doi/10.1021/i300010a030https://doi.org/10.1021/i300010a030research-articleACS PublicationsRequest reuse permissionsArticle Views875Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Small bowel neuroendocrine tumors: From pathophysiology to clinical approach (2016)

Neuroendocrine tumors (NETs), defined as epithelial tumors with predominant neuroendocrine differentiation, are among the most frequent types of small bowel neoplasm. They represent a rare, slow-growing neoplasm with some characteristics common to all forms and others attributable to the organ of origin. The diagnosis of this subgroup of neoplasia is not usually straight-forward for several reasons. Being a rare form of neoplasm they are frequently not readily considered in the differential diagnosis. Also, clinical manifestations are nonspecific lending the clinician no clue that points directly to this entity. However, the annual incidence of NETs has risen in the last years to 40 to 50 cases per million probably not due to a real increase in incidence but rather due to better diagnostic tools that have become progressively available. Being a rare malignancy, investigation regarding its pathophysiology and efforts toward better understanding and classification of these tumors has been limited until recently. Clinical societies dedicated to this matter are emerging (NANETS, ENETS and UKINETS) and several guidelines were published in an effort to standardize the nomenclature, grading and staging systems as well as diagnosis and management of NETs. Also, some investigation on the genetic behavior of small bowel NETs has been recently released, shedding some light on the pathophysiology of these tumors, and pointing some new directions on the possible treating options. In this review we focus on the current status of the overall knowledge about small bowel NETs, focusing on recent breakthroughs and its potential application on clinical practice.
Total synthesis of (+)-A83543A [(+)-lepicidin A] (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+)-A83543A [(+)-lepicidin A]David A. Evans and W. Cameron BlackCite this: J. Am. Chem. Soc. 1993, 115, 11, 4497–4513Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://doi.org/10.1021/ja00064a011RIGHTS & PERMISSIONSArticle Views4491Altmetric-Citations271LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Automatic Entity Recognition and Typing from Massive Text Corpora (2015)

In today's computerized and information-based society, we are soaked with vast amounts of text data, ranging from news articles, scientific publications, product reviews, to a wide range of textual information from social media. To unlock the value of these unstructured text data from various domains, it is of great importance to gain an understanding of entities and their relationships. In this tutorial, we introduce data-driven methods to recognize typed entities of interest in massive, domain-specific text corpora. These methods can automatically identify token spans as entity mentions in documents and label their types (<i>e.g.</i>, people, product, food) in a scalable way. We demonstrate on real datasets including news articles and tweets how these typed entities aid in knowledge discovery and management.
Optical Properties of Semiconductor Nanocrystals (1998)

Low-dimensional semiconductor structures, often referred to as nanocrystals or quantum dots, exhibit fascinating behavior and have a multitude of potential applications, especially in the field of communications. This book examines in detail the optical properties of these structures, giving full coverage of theoretical and experimental results, and discusses their technological applications. The author begins by setting out the basic physics of electron states in crystals (adopting a 'cluster-to-crystal' approach), and goes on to discuss the growth of nanocrystals, absorption and emission of light by nanocrystals, optical nonlinearities, interface effects, and photonic crystals. He illustrates the physical principles with references to actual devices such as novel light-emitters and optical switches.
POTENCIAL PESQUERO Y ESTUDIOS ECOLOGICOS DE BAHlA MAGDALENA 1. LAS EXISTENCIAS DE CAMARON CON REFERENCIA ESPECIAL AL CAMARON DE ROCA 0 CAMARON JAPONES. (1975)

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Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry (2006)

The neurobiological mechanisms underlying overeating in obesity are not understood. Here, we assessed the neurobiological responses to an Implantable Gastric Stimulator (IGS), which induces stomach expansion via electrical stimulation of the vagus nerve to identify the brain circuits responsible for its effects in decreasing food intake. Brain metabolism was measured with positron emission tomography and 2-deoxy-2[18F]fluoro-D-glucose in seven obese subjects who had the IGS implanted for 1-2 years. Brain metabolism was evaluated twice during activation (on) and during deactivation (off) of the IGS. The Three-Factor Eating Questionnaire was obtained to measure the behavioral components of eating (cognitive restraint, uncontrolled eating, and emotional eating). The largest difference was in the right hippocampus, where metabolism was 18% higher (P < 0.01) during the "on" than "off" condition, and these changes were associated with scores on "emotional eating," which was lower during the on than off condition and with "uncontrolled eating," which did not differ between conditions. Metabolism also was significantly higher in right anterior cerebellum, orbitofrontal cortex, and striatum during the on condition. These findings corroborate the role of the vagus nerve in regulating hippocampal activity and the importance of the hippocampus in modulating eating behaviors linked to emotional eating and lack of control. IGS-induced activation of regions previously shown to be involved in drug craving in addicted subjects (orbitofrontal cortex, hippocampus, cerebellum, and striatum) suggests that similar brain circuits underlie the enhanced motivational drive for food and drugs seen in obese and drug-addicted subjects, respectively.