gebhart/patrepeval huggingface dataset:
A Secure Software Download Framework Based on Mobile Trusted Computing (2009)

The number of software deployed on mobile terminals is dramatically increasing. However, this leads the mobile terminal facing a serious of security threats. In order to resolve these threat issues, several security requirements are proposed. Also, this paper introduces a secure software download framework and corresponding download protocol based on mobile trusted computing, designed to handle a collection of activities in software download. Such activities include authentication, download and installation of the software. The core part of the framework is a discretionary engine--device management engine (DME), which provides entity authentication, integrity protection and remote attestation for the mobile device. By the introduction of software description file, we provide a mechanism to transfer reference integrity metric (RIM), which makes up for the shortage of the specification.
Cigarette Smoking and Spontaneous Abortion of Known Karyotype: Precise Data but Uncertain Inferences (1995)

Data from the first phase (1974-1979) of this New York City case-control study showed that 1) cigarette smoking during pregnancy was associated positively with chromosomally normal spontaneous abortion and 2) both past and current smoking were associated inversely with trisomic loss in women under age 30 years and positively in older women. The authors used data from two subsequent study phases (1979-1982 and 1982-1986) to test the stability of these associations over time and the homogeneity between payment groups (private vs. public). Spontaneous abortions (cases) were classified as chromosomally normal (n = 1,388), trisomic (n = 557), or other chromosomally aberrant (n = 409). Controls (n = 4,165) were women who had registered for prenatal care before 22 weeks' gestation and delivered at 28 weeks or later. For chromosomally normal loss, later data gave modest support to prior observations. In the total sample, current smoking (defined as smoking during the month of the last menstrual period) of 14 or more cigarettes per day was increased among chromosomally normal cases in comparison with controls (adjusted odds ratio (OR) = 1.3, 95% confidence interval (CI) 1.1-1.7) and in comparison with other aberrant cases (adjusted OR = 1.2, 95% CI 0.8-1.8). Stronger associations in public patients than in private patients (adjusted odds ratios of 1.4-1.5 versus 0.8-0.9, respectively) might indicate either a mediating effect of social disadvantage or a chance fluctuation. For trisomic loss, later data did not support prior observations. Associations between trisomy and past or current smoking did not vary significantly with age in either payment group; assuming no effect modification of age, adjusted odds ratios for smoking in relation to trisomy were 0.9-1.0.
Flavopiridol induces<i>BCL-2</i>expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia (2011)

Flavopiridol is a cyclin-dependent kinase inhibitor that induces cell cycle arrest, apoptosis, and clinical responses in selected patients with acute myeloid leukemia (AML). A better understanding of the molecular pathways targeted by flavopiridol is needed to design optimal combinatorial therapy. Here, we report that in vivo administration of flavopiridol induced expression of the BCL-2 anti-apoptotic gene in leukemic blasts from adult patients with refractory AML. Moreover, flavopiridol repressed the expression of genes encoding oncogenic transcription factors (HMGA1, STAT3, E2F1) and the major subunit of RNA Polymerase II. Our results provide mechanistic insight into the cellular pathways targeted by flavopiridol. Although further studies are needed, our findings also suggest that blocking anti-apoptotic pathways could enhance cytotoxicity with flavopiridol.
Menstrual disturbances – a rare side-effect of bright-light therapy (2004)

Seasonal affective disorder (SAD; autumn–winter depression) is a form of recurrent depressive or bipolar disorder, that affects up to 4% of the general population (Kasper et al., 1989). Bright-light therapy (BLT) has been proven to be an effective and well-tolerated treatment for patients suffering from autumn–winter depression. This report presents the case of a patient experiencing menstrual disturbances during light therapy.
Acoustic measures of the cry characteristics of healthy newborns and newborns with pathologies (2013)

Several hypotheses have been formulated as a result of observing spectrograms of the audio signals of the newborn infant cry in numerous studies. Our study is based on a few of these hypotheses. The purpose of this article is to differentiate pathological crying from healthy crying through acoustic cry analysis based on neurophysiological parameters of newborns. The automatic estimation of the characteristics of relevant cry signals, such as phonation, hyperphonation, and dysphonation, expressed as percentages, as well as unvoiced sound and mode change percentages, have enabled us to distinguish among the pathologies selected for this study. The results obtained have helped us to make quantitative associations between cry characteristics and pathological conditions affecting newborns.
The domestic induction heating appliance: An overview of recent research (2008)

In this paper several research topics pertaining to the design and modeling of domestic induction appliances are reviewed. Each topic is summarized, stressing its most significant advances and pointing to its future tendencies. A bibliographic review showing some of the published papers during the last years is included. The emphases and relative contributions of some of them are also discussed.
Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses (2018)

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 (A1), in retinal ischemia-reperfusion (IR) injury. A1 competes with nitric oxide synthase (NOS) for their common substrate L-arginine. A1-mediated L-arginine depletion reduces nitric oxide (NO) formation by NOS leading to vascular dysfunction when endothelial NOS is involved but prevents inflammatory injury when inducible NOS is involved. Studies were performed using wild-type (WT) mice, global A1<sup>+/</sup><sup>-</sup> knockout (KO), endothelial-specific A1 KO, and myeloid-specific A1 KO mice subjected to retinal IR injury. Global as well as myeloid-specific A1 KO mice showed worsened IR-induced neuronal loss and retinal thinning. Deletion of A1 in endothelial cells had no effect, while treatment with PEGylated (PEG) A1 improved neuronal survival in WT mice. In addition, A1<sup>+/-</sup> KO mice showed worsened vascular injury manifested by increased acellular capillaries. Western blotting analysis of retinal tissue showed increased inflammatory and necroptotic markers with A1 deletion. In vitro experiments showed that macrophages lacking A1 exhibit increased inflammatory response upon LPS stimulation. PEG-A1 treatment dampened this inflammatory response and decreased the LPS-induced metabolic reprogramming. Moreover, intravitreal injection of A1 KO macrophages or systemic macrophage depletion with clodronate liposomes increased neuronal loss after IR injury. These results demonstrate that A1 reduces IR injury-induced retinal neurovascular degeneration via dampening macrophage inflammatory responses. Increasing A1 offers a novel strategy for limiting neurovascular injury and promoting macrophage-mediated repair.
Can vitamin B12 be an adjuvant to COVID-19 treatment? (2020)

COVID-19 has become an international pandemic and is causing a worldwide public health emergency; therefore, an effective treatment is urgently needed. The hypothesis is that Covid virus interferes with the cobalamin metabolism, causing symptoms of cobalamin deficiency. This is plausible to infer, because there are symptoms of vitamin B12 deficiency that are similar to those of COVID-19. These symptoms include increase oxidative stress, homocysteine concentration, activation of the coagulation cascade, thrombocytopenia, elevated lactate dehydrogenase (LDH), low reticulocyte count, intravascular coagulation thrombosis, vasoconstriction, renal and pulmonary vasculopathies, which can result in respiratory, gastrointestinal and central nervous system disorders. Research shows that high doses of methylcobalamin is the treatment for symptoms of vitamin B12 deficiency. Thus, an additional hypothesis is that treatment with vitamin B12, especially methylcobalamin, would reduce Covid's damage to infected patients. Hence, in this review article it is suggested that methylcobalamin (vitamin B12) may serve as an attenuator to COVID-19 symptoms. Clinical studies are required to confirm this hypothesis.
Identification of CtBP1 and CtBP2 as Corepressors of Zinc Finger-Homeodomain Factor δEF1 (1999)

deltaEF1, a representative of the zinc finger-homeodomain protein family, is a transcriptional repressor which binds E2-box (CACCTG) and related sequences and counteracts the activators through transrepression mechanisms. It has been shown that the N-proximal region of the protein is involved in the transrepression. Here we demonstrate that deltaEF1 has a second mechanism of transrepression recruiting CtBP1 or CtBP2 as its corepressor. A two-hybrid screen of mouse cDNAs with various portions of deltaEF1 identified these proteins, which bind to deltaEF1 in a manner dependent on the PLDLSL sequence located in the short medial (MS) portion of deltaEF1. CtBP1 is the mouse orthologue of human CtBP, known as the C-terminal binding protein of adenovirus E1A, while CtBP2 is the second homologue. Fusion of mouse CtBP1 or CtBP2 to Gal4DBD (Gal4 DNA binding domain) made them Gal4 binding site-dependent transcriptional repressors in transfected 10T1/2 cells, indicating their involvement in a transcriptional repression mechanism. When the MS portion of deltaEF1 was used to Gal4DBD and used to transfect cells, a strong transrepression activity was generated, but this activity was totally dependent on the PLDLSL sequence which served as the site for interaction with endogenous CtBP proteins, indicating that CtBP1 and -2 can act as corepressors. Exogenous CtBP1/2 significantly enhanced transcriptional repression by deltaEF1, and this enhancement was lost if the PLDLSL sequence was altered, demonstrating that CtBP1 and -2 act as corepressors of deltaEF1. In the mouse, CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. In developing embryos, CtBP1 and CtBP2 are expressed broadly with different tissue preferences. Remarkably, their high expression occurs in subsets of deltaEF1-expressing tissues, e.g., cephalic and dorsal root ganglia, spinal cord, posterior-distal halves of the limb bud mesenchyme, and perichondrium of forming digits, supporting the conclusion that CtBP1 and -2 play crucial roles in the repressor action of deltaEF1 in these tissues.
CpG Immunomer DNA Enhances Antisense Protein Kinase A RIα Inhibition of Multidrug-Resistant Colon Carcinoma Growth in Nude Mice: Molecular Basis for Combinatorial Therapy (2005)

These results show that type I PKA down-regulation and induction of apoptosis in tumor cells by antisense PKA RIalpha, and host-immune stimulation by CpG immunomer are responsible at the molecular level for the supra-additive effects of tumor growth inhibition. Thus, antisense PKA RIalpha and CpG immunomer in combination work cooperatively and as tumor-targeted therapeutics to treat human cancer.
Frequency division transmission imaging and synthetic aperture reconstruction (2006)

In synthetic transmit aperture imaging only a few transducer elements are used in every transmission, which limits the signal-to-noise ratio (SNR). The penetration depth can be increased by using all transmitters in every transmission. In this paper, a method for exciting all transmitters in every transmission and separating them at the receiver is proposed. The coding is done by designing narrow-band linearly frequency modulated signals, which are approximately disjointed in the frequency domain and assigning one waveform to each transmitter. By designing a filterbank consisting of the matched filters corresponding to the excitation waveforms, the different transmitters can be decoded at the receiver. The matched filter of a specific waveform will allow information only from this waveform to pass through, thereby separating it from the other waveforms. This means that all transmitters can be used in every transmission, and the information from the different transmitters can be separated instantaneously. Compared to traditional synthetic transmit aperture (STA) imaging, in which the different transmitters are excited sequentially, more energy is transmitted in every transmission, and a better signal-to-noise-ratio is attained. The method has been tested in simulation, in which the resolution and contrast was compared to a standard synthetic transmit aperture system with a single sinusoid excitation. The resolution and contrast was comparable for the two systems. The method also has been tested using the experimental ultrasound scanner RASMUS. The resolution was evaluated using a string phantom. The method was compared to a conventional STA using both sinusoidal excitation and linear frequency modulated (FM) signals as excitation. The system using the FM signals and the frequency division approach yielded the same performance concerning both axial (of approximately equal to 3 wavelengths) and lateral resolution (of approximately equal to 4.5 wavelengths). A SNR measurement showed an increase in SNR of 6.5 dB compared to the system using the conventional STA method and FM signal excitation.
Characterization of a Legionella micdadei mip mutant (1995)

The pathogenesis of Legionella micdadei is dependent upon its ability to infect alveolar phagocytes. To better understand the basis of intracellular infection by this organism, we examined the importance of its Mip surface protein. In Legionella pneumophila, Mip promotes infection of both human macrophages and freshwater protozoa. Southern hybridization and immunoblot analyses demonstrated that mip sequences were present and expressed within a panel of virulent L. micdadei strains. Using allelic exchange mutagenesis, we then constructed an L. micdadei strain that completely and specifically lacked Mip. Although unimpaired in its ability to grow in bacteriologic media, this Mip mutant was defective in its capacity to infect U937 cells, a human macrophage-like cell line. Most significantly, the Mip- organism displayed a 24-fold reduction in survivability immediately after its entry into the phagocyte. Similarly, the mutant was less able to parasitize Hartmannella amoebae. Taken together, these data argue that Mip specifically potentiates intracellular growth by L. micdadei.
Tail current flicker noise reduction in LC VCOs by complementary switched biasing (2003)

A new LC voltage-controlled oscillator circuit topology is proposed, in which the flicker noise generated by the tail transistor is noticeably reduced by utilizing the phenomenon of flicker noise intrinsic reduction due to switched biasing. A macro model of MOSFET under switched biasing is used to prove the idea. Circuit simulations are done on two oscillators with the same tail current value; one with fixed biasing and the other with the proposed switching. A 4 dBc/Hz phase noise improvement is achieved at 1 kHz frequency offset in the switched biasing scheme under the same power dissipation and tuning range.
Quadtree Algorithms for Contouring Functions of Two Variables (1990)

Two grid-based algorithms are presented for contouring functions of two variables over square plotting areas. The algorithms are simple to code, and achieve considerable efficiency through the use of quadtree techniques to produce non-uniform subdivisions of the plotting areas. One algorithm uses curvature properties of the functions being plotted to produce plotting cells of optimal size, and their relative speeds depend on the complexity of the functions. Both algorithms can be adapted for plotting over rectangular area.
Thioheteroanions—Unusual Metal‐Ligand Interaction and Reactions (1977)

The first reaction products of “heteroanions” such as in (1) could now be isolated. An example is the brownish‐red salt (2) which is one of the few pentacoordinate Co compounds. equation image
Secondary Ion Mass Spectrometry For The Year 2000 and Beyond: Are There Any Showstoppers? (1997)

Abstract The National Technology Roadmap of Semiconductors (NTRS) shows that future semiconductor processing will require the formation of junctions less than 30nm deep with gate lengths approaching, and becoming less than, 0.lum. Techniques must be available to measure these in-depth, as well as spatial, distributions. Secondary ion mass spectrometry (SIMS) has long been the technique of choice for measuring dopant profiles in semiconductors. The depth of the junctions formed has, up top now, always been sufficiently deep into the semiconductor that the effects of the analysis on the measured profile (i.e. atomic mixing) could be ignored for the most part. In addition, gate lengths have been sufficiently large that diffusion of LDD implants under the gate have not contributed significantly to short-channel effects. However, the relentless decrease in the required junction depths and gate lengths may mean that the situation may change in the near future.
STUDY ON CHOLESTEROL LOWERING COMPOUNDS IN RED YEAST RICE PREPARED FROM THAI GLUTINOUS RICE (2010)

Red yeast rice which is a product of solid fermentation was prepared from several kinds of Thai glutinous rice (Oryza sativa L.) cv. Kor Kho 6 (RD6), Kam (Kam) and Sanpatong1 (SPT1). Monascus purpureus CMU001 isolated from available Chinese red yeast rice was used as the fermentation starter. The analysis for the presence and the content of monacolins, the cholesterol lowering compounds, were carried out using high performance liquid chromatography (HPLC). The presence of the monacolins was confirmed by the retention time of the reference compounds and LC-MS. The results were compared to those obtained from the Chinese redyeast rice and Thai non-glutinous rice (Oryza sativa L. cv. Mali105).The chromatograms shows the presence of monacolin K acid form (MKA), compactin (P1) , monacolin M acid form (MMA), monacolin K (MK), monacolin M (MM) and dehydromonacolin K (DMK). A large peak of a compound with the molecular weight of 358 was also detected but cannot be identified. The amount of two important monacolins, compactin and monacolin K, were determined. It was found that the highest amount of compactin and monacolin K were 21.98 and 33.79 mg/g respectively when using Thai rice varity Oryza sativa L. cv. RD6 which was fermented without adding soybean milk. Keyword: Glutinous rice, HMG-CoA reductase, Monacolins, Monascus purpureus,Red yeast rice.
Los manuscritos americanos de la Biblioteca Histórica "Marqués de Valdecilla" UCM (2013)

La Biblioteca Historica de la Universidad Complutense de Madrid posee un pequeno conjunto de diecisiete manuscritos americanos, bien copiados en America o de tema americano. Entre ellos destacan algunas piezas excepcionales, como una copia de la Materia Medicinal de Francisco Hernandez del siglo XVI, una cronica del noble indigena Fernando Alva Ixtlilxochitl del siglo XVII, o el conjunto de papeles relativos a la conspiracion de La Guaira, de finales del siglo XVIII. Entre los manuscritos del siglo XX se encuentran desde un conjunto de documentos que la pedagoga cubana Carolina Poncet envio a Rafael Altamira, a copias de distintos trabajos academicos de la decada de los anos treinta. Las procedencias son variadas, destacando las seis del legado Francisco Guerra.
ChemInform Abstract: Synthesis of Cyanoalkyltetrazoles. (1989)

Abstract As little is known about the synthesis and the properties of the title compounds, C‐ and N‐substituted cyanoalkyltetrazoles (III), (IV) and (VII) are prepared by the procedures shown in the scheme.
Delay Compensation for Nonlinear, Adaptive, and PDE Systems (2009)

Some of the most common dynamic phenomena that arise in engineering practice—actuator and sensor delays—fall outside the scope of standard finite-dimensional system theory. The first attempt at infini
L‐Dihydroxyphenylserine (L‐DOPS): A Norepinephrine Prodrug (2006)

L-threo-3,4-dihydroxyphenylserine (L-DOPS, droxydopa) is a synthetic catecholamino acid. When taken orally, L-DOPS is converted to the sympathetic neurotransmitter, norepinephrine (NE), via decarboxylation catalyzed by L-aromatic-amino-acid decarboxylase (LAAAD). Plasma L-DOPS levels peak at about 3 h, followed by a monoexponential decline with a half-time of 2 to 3 h. Plasma levels of NE and of its main neuronal metabolite, dihydroxyphenylglycol (DHPG) peak approximately concurrently but at much lower concentrations. The relatively long half-time for disappearance of L-DOPS from plasma, compared to that of NE, explains their very different attained plasma concentrations. In patients with neurogenic orthostatic hypotension, L-DOPS increases blood pressure and ameliorates orthostatic intolerance. Inhibition of LAAAD, such as by treatment with carbidopa, which does not penetrate the blood-brain barrier, prevents the blood pressure effects of the drug, indicating that L-DOPS increases blood pressure by augmenting NE production outside the brain. Patients with pure autonomic failure (which usually entails loss of sympathetic noradrenergic nerves), and patients with multiple system atrophy (in which noradrenergic innervation remains intact) have similar plasma NE responses to L-DOPS. This suggests mainly non-neuronal production of NE from L-DOPS. L-DOPS is very effective in treatment of deficiency of dopamine-beta-hydroxylase (DBH), the enzyme required for conversion of dopamine to NE in sympathetic nerves. L-DOPS holds promise for treating other much more common conditions involving decreased DBH activity or NE deficiency, such as a variety of syndromes associated with neurogenic orthostatic hypotension.
Comparison of cloned genes provides evidence for intergenomic exchange of DNA in the evolution of a tobacco glucan endo-1,3-beta-glucosidase gene family. (1991)

Two genes for prepro glucan endo-1,3-beta-glucosidase (1,3-beta-glucanase; 1,3-beta-D-glucan glucanohydrolase, EC 3.2.1.39) of tobacco were cloned and their sequences were compared with cDNA clones. Southern analysis indicates that the genomic clones represent genes derived from ancestral parents of tobacco similar to the present day species Nicotiana sylvestris and Nicotiana tomentosiformis, whereas the genes represented by two of the cDNA clones appear to be unique to tobacco. The coding sequences of the genomic clones and cDNA clones differed at less than 2.2% of the positions, indicating that the tobacco 1,3-beta-glucanase gene family is highly conserved. Alternating blocks of sequence in the cDNA clones were identical to the coding sequence of the two genomic clones. These results and an analysis of evolutionary distances for nucleotide substitution are consistent with the hypothesis that the evolution of the tobacco 1,3-beta-glucanase gene family has involved exchange of DNA between members of the tomentosiformis and sylvestris subgenomes by recombination or gene conversion.