gebhart/patrepeval huggingface dataset:
Wideband direction finding using a photonic robust symmetrical number system technique (2014)

Dual electrode Mach–Zehnder modulators (DE-MZMs) are used to conduct phase detection for direct wideband direction finding (DF) of microwave signals. It is demonstrated theoretically and through simulation and experimentation that the normalized magnitude of the output signal phase detector circuit is equal to |sin(ψ/2)|, where ψ is the phase difference between the plane waves arriving at the reference and measurement antennas of a linear DF array. A four-element wideband photonic DF system with robust symmetrical number system preprocessing is presented. Simulation and experimental testing results are provided to demonstrate the theoretical concept. The results demonstrate a direct DF receiver using DE-MZMs that achieves fine angular resolution using a much smaller array size than is typically required for linear arrays employing super-resolution signal processing techniques.
Positive modulators of the AMPA receptor (2000)

Alterations in the excitatory neurotransmission by AMPA-type (α-methyl3-hydroxy-5-methyl-4-isoxazol-4-ylpropionic acid) glutamate receptors may be involved in the aetiology of neurological diseases such as Alzheimer’s disease and schizophrenia. The potentiation of AMPA-receptor mediated synaptic transmission by allosteric positive modulators of this receptor (Ampakines™) may have beneficial behavioural effects in these diseases. The development of compounds acting as Ampakines has led to CX516 (Ampalex™, Cortex Pharmaceuticals), which has reached the early stage of clinical trials for schizophrenia. The number of structural classes of compounds reported in the patent literature as positive modulators of the AMPA receptor is expanding from the earlier benzoyl piperidine (aniracetam) and thiazide (cyclothiazide, diazoxide) chemical series. This review covers the patent literature from the last five years (January 1995 to June 2000) in which there are claims for positive modulators of the AMPA receptor.
BMY-28190, a novel antiviral antibiotic complex. (1988)

BMY-28190, an antibiotic complex active against herpes simplex virus type 1 (HSV-1) was produced by the cultured broth of Streptoalloteichus hindustanus sp. nov., a producing strain of tallysomycins A and B. The antibiotic complex was recovered from the broth with Amberlite IRC-50 resin and separated from the coproduced tallysomycins and nebramycins by a series of chromatographies. BMY-28190 exhibited weak inhibitory activity toward Gram-positive and Gram-negative bacteria and strong inhibitory activity toward HSV-1. Structural studies disclosed that BMY-28190 is a novel complex of gamma-poly-D-alpha, gamma-diaminobutyric acids with an average MW of 5,130.
Hepatitis C Virus Variants with Decreased Sensitivity to Direct-Acting Antivirals (DAAs) Were Rarely Observed in DAA-Naive Patients prior to Treatment (2012)

The prevalence of naturally occurring hepatitis C virus (HCV) variants that are less sensitive to direct-acting antiviral (DAA) inhibitors has not been fully characterized. We used population sequence analysis to assess the frequency of such variants in plasma samples from 3,447 DAA-naive patients with genotype 1 HCV. In general, HCV variants with lower-level resistance (3- to 25-fold increased 50% inhibitor concentration [IC(50)]) to telaprevir were observed as the dominant species in 0 to 3% of patients, depending on the specific variant, whereas higher-level resistant variants (>25-fold-increased IC(50)) were not observed. Specific variants resistant to NS5A inhibitors were predominant in up to 6% of patients. Most variants resistant to nucleo(s/t)ide active-site NS5B polymerase inhibitors were not observed, whereas variants resistant to non-nucleoside allosteric inhibitors were observed in up to 18% of patients. The presence of DAA-resistant variants in NS5A, NS5B, or NS3 (including telaprevir-resistant variants), in baseline samples of treatment-naive patients receiving a telaprevir-based regimen in phase 3 studies did not affect the sustained viral response (SVR). Treatment-naive patients with viral populations containing the telaprevir-resistant variants NS3 V36M, T54S, or R155K at baseline achieved a 74% SVR rate, whereas patients with no resistant variants detected prior to treatment achieved a 76% SVR rate. The effect of specific resistant variant frequency on response to various DAA treatments in different patient populations, including interferon nonresponders, should be further studied.
Cumulative irritation patch test of sanitary pads on sensitive skin (2005)

Sanitary pads under investigation elicited negligible cumulative irritation in a four-day patch test on subjects with self-declared sensitive skin. The temporal pattern of cumulative response was consistent with the inherently low irritation potential of the products.
An<i>in vivo</i>study of novel bioactive peptides that inhibit the growth of<i>Escherichia coli</i> (2001)

We have created a system in which synthetically produced novel bioactive peptides can be expressed in vivo in Escherichia coli. Twenty thousand of these peptides were screened and 21 inhibitors were found that could inhibit the growth of E. coli on minimal media. The inhibitors could be placed into one of two groups, 1-day inhibitors, which were partially inhibitory, and 2-day inhibitors, which were completely inhibitory. Sequence analysis showed that two of the most potent inhibitors were actually peptide-protein chimeras in which the peptides had become fused to the 63 amino acid Rop protein which was also contained in the expression vector used in this study. Given that Rop is known to form an incredibly stable structure, it could be serving as a stabilizing motif for these peptides. Sequence analysis of the predicted coding regions from the next 10 most inhibitory peptides showed that four of the 10 peptides contained one or more proline residues either at or very near the C-terminal end of the peptide which could act to prevent degradation by peptidases. Collectively, based on what we observed in our screen of synthetic bioactive peptides that could prevent the growth of E. coli and what has been learned from structural studies of naturally occurring bioactive peptides, the presence of a stabilizing motif seems to be important for small peptides, if they are to be biologically active.
29.2 A Scalable Quantum Magnetometer in 65nm CMOS with Vector-Field Detection Capability (2019)

Room-temperature control and detection of the nitrogen vacancy (NV) center in diamond's spin-state has enabled magnetic sensing with high sensitivity and spatial resolution [1], [2]. However, current NV sensing apparatuses use bulky off-the-shelf components, which greatly increase the system's scale. In [3], a compact platform, which attaches nanodiamond particles to a CMOS sensor, shrinks this spin-based magnetometer to chip scale; however, the optically detected magnetic resonance (ODMR) curve it generates carries large fluctuation leading to inferior sensitivity. In this paper, we present a CMOS-NV quantum sensor with (i) a highly-scalable microwave-delivering structure and (ii) a Talbot-effect-based photonic filter with enhanced green-to-red suppression ratio. The former enables coherent driving of an increased number of NV centers, and the latter reduces the shot noise of the photo-detector caused by the input green laser. In addition, the usage of a bulk diamond also enables vector magnetometry, which allows for the tracking of magnetic objects and navigation. The prototype sensor provides a measured vector-field sensitivity of 245nT/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> .
Development of Blade Profiles for Low Pressure Turbine Applications (1996)

This paper describes a programme of work, largely experimental, which was undertaken with the objective of developing an improved blade profile for the low-pressure turbine in aero-engine applications. Preliminary experiments were conducted using a novel technique. An existing cascade of datum blades was modified to enable the pressure distribution on the suction surface of one of the blades to be altered. Various means, such as shaped inserts, an adjustable flap at the trailing edge, and changing stagger were employed to change the geometry of the passage. These experiments provided boundary layer and lift data for a wide range of suction surface pressure distributions. The data was then used as a guide for the development of new blade profiles. The new blade profiles were then investigated in a low-speed cascade that included a set of moving bars upstream of the cascade of blades 10 simulate the effect of the incoming wakes from the previous blade row in a multistage turbine environment. Results are presented for two improved profiles that are compared with a datum representative of current practice. The experimental results include loss measurements by wake traverse, surface pressure distributions, and boundary layer measurements. The cascades were operated over a Reynolds Number range from 0.7 × 105 to 4.0 × 105. The first profile is a “laminar flow” design that was intended to improve the efficiency at the same loading as the datum. The other is a more highly loaded blade profile intended to permit a reduction in blade numbers. The more highly loaded profile is the most promising candidate for inclusion in future designs. It enables blade numbers to be reduced by 20%, without incurring any efficiency penalty. The results also indicate that unsteady effects must be taken into consideration when selecting a blade profile for the low-pressure turbine.
Multi-colorimetric sensor array for detection of explosives in gas and liquid phase (2011)

In the framework of the research project "Xsense" at the Technical University of Denmark (DTU) we are developing a simple colorimetric sensor array which can be useful in detection of explosives like DNT, TATP, HMX, RDX and identification of reagents needed for making homemade explosives. The technology is based on an array of chemoselective compounds immobilized on a solid support. Upon exposure to the analyte in suspicion the colorimetric array changes color. Each chosen compound reacts chemo-selectively with analytes of interest. A change in a color signature indicates the presence of unknown explosives and volatile organic compounds (VOCs). We are working towards the selection of compounds that undergo color changes in the presence of explosives and VOCs, as well as the development of an immobilization method for the molecules. Digital imaging of the colorimetric array before and after exposure to the analytes creates a color difference map which gives a unique fingerprint for each explosive and VOCs. Such sensing technology can be used for screening relevant explosives in a complex background as well as to distinguish mixtures of volatile organic compounds distributed in gas and liquid phases. This sensor array is inexpensive, and can potentially be produced as single use disposable.
The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial (2010)

Most osteoporosis drugs act by inhibiting bone resorption. A need exists for osteoporosis therapies that stimulate new bone formation. 2-Methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD) is a vitamin D analogue that potently stimulates bone formation activity in vitro and in the ovariectomized rat model. In this randomized, double-blind, placebo-controlled study of osteopenic women, the effect of daily oral treatment with 2MD on bone mineral density (BMD), serum markers of bone turnover, and safety were assessed over 1 year. Volunteers were randomly assigned to three treatment groups: placebo (n = 50), 220 ng of 2MD (n = 54), and 440 ng of 2MD (n = 53). In general, 2MD was well tolerated. Although 2MD caused a marked increase in markers of bone formation, it did not significantly increase BMD. Since 2MD also shows marked activity on bone resorption (as revealed by dose-dependent increases in serum C-telopeptide cross-links of type I collagen in this study), 2MD likely stimulated both bone formation and bone resorption, thereby increasing bone remodeling.
Heteroleptic Ir(<scp>iii</scp>) phosphors with bis-tridentate chelating architecture for high efficiency OLEDs (2015)

Emissive Ir(<sc>iii</sc>) complexes bearing two tridentate chelates were synthesized. The multiple coordination mode of the chelate warrants a new class of metal-based phosphors for OLED applications.
How to consider shorts and guarantee yield rate improvement for redundant wire insertion (2009)

This paper accurately considers wire short defects and proposes an algorithm to guarantee IC chip yield rate improvement for redundant wire insertion. Without considering yield rate degradation caused by shorts, traditional methods may even lead to yield rate loss. However, shorts are more complicated to analyze than opens. Moreover, since any two points of a routed net can be connected by a redundant wire, the number of possible insertion patterns for a chip is un-tractable. To maximize yield rate improvement and to make the problem tractable, we identify a key insight, tolerance-ratio, as an effective guide for choosing insertion patterns and insertion order. Finally, to guarantee yield rate improvement, only positive gain redundant wires are committed. Experimental results show that, compared with unprocessed cases, all yield rate improvements in the proposed algorithm are positive, and the defect rates are reduced by up to 65% and by 24% on average. On the other hand, without considering shorts, the defect rate can increase as much as 7%.
Real-time localization of the parathyroid gland in surgical field using Raspberry Pi during thyroidectomy: a preliminary report (2018)

We created an auto-para viewer, an autofluorescence imaging device, to localize the parathyroid glands during thyroidectomy using an inexpensive Raspberry Pi. A special emission filter in the auto-para viewer was designed to pass 1/100 of visible light and nearly all infrared light longer than 808 nm. With this emission filter, we simultaneously acquired an autofluorescence image of the parathyroid and a visible light image of the surrounding surgical field. The auto-para viewer displayed four times brighter autofluorescence of the parathyroid glands compared to the background tissues without operating room light. Additionally, it showed two times brighter autofluorescence than the background tissues simultaneously showing the surgical field illuminated by the visible light from the operating room light. The NOIR camera, using the auto-para viewer, could reduce the camera's exposure time so the parathyroid glands to be viewed in real-time, which is expected to prevent unintentional damage to the parathyroid gland during thyroidectomy.
A hybrid learning approach for semantic labeling of cardiac CT slices and recognition of body position (2016)

We work towards efficient methods of categorizing visual content in medical images as a precursor step to segmentation and anatomy recognition. In this paper, we address the problem of automatic detection of level/position for a given cardiac CT slice. Specifically, we divide the body area depicted in chest CT into nine semantic categories each representing an area most relevant to the study of a disease and/or key anatomic cardiovascular feature. Using a set of handcrafted image features together with features derived form a deep convolutional neural network (CNN), we build a classification scheme to map a given CT slice to the relevant level. Each feature group is used to train a separate support vector machine classifier. The resulting labels are then combined in a linear model, also learned from training data. We report margin zero and margin one accuracy of 91.7% and 98.8% and show that this hybrid approach is a very effective methodology for assigning a given CT image to a relatively narrow anatomic window.
A fiber-optic water flow sensor based on laser-heated silicon Fabry-Pérot cavity (2016)

A hot-wire fiber-optic water flow sensor based on laser-heated silicon Fabry-Pérot interferometer (FPI) has been proposed and demonstrated in this paper. The operation of the sensor is based on the convective heat loss to water from a heated silicon FPI attached to the cleaved enface of a piece of single-mode fiber. The flow-induced change in the temperature is demodulated by the spectral shifts of the reflection fringes. An analytical model based on the FPI theory and heat transfer analysis has been developed for performance analysis. Numerical simulations based on finite element analysis have been conducted. The analytical and numerical results agree with each other in predicting the behavior of the sensor. Experiments have also been carried to demonstrate the sensing principle and verify the theoretical analysis. Investigations suggest that the sensitivity at low flow rates are much larger than that at high flow rates and the sensitivity can be easily improved by increasing the heating laser power. Experimental results show that an average sensitivity of 52.4 nm/(m/s) for the flow speed range of 1.5 mm/s to 12 mm/s was obtained with a heating power of ~12 mW, suggesting a resolution of ~1 μm/s assuming a wavelength resolution of 0.05 pm.
Field-inhomogeneity-corrected low-rank filtering of magnetic resonance spectroscopic imaging data (2014)

Low signal-to-noise ratio has been a major problem in magnetic resonance spectroscopic imaging (MRSI). A low-rank approximation based denoising method has been recently proposed to address this problem by exploiting the partial separability properties of MRSI data. However, field inhomogeneity, an unavoidable complication in practice, can violate the partial separability assumption and thus degrade the denoising performance of the low-rank filtering method. This paper presents a field-inhomogeneity-corrected low-rank filtering method to achieve more robust denoising of practical MRSI data. In vivo experiment results have been used to demonstrate the effectiveness of the proposed method.
Electrotransport of Uranium from a Liquid Cadmium Anode to a Solid Cathode (2002)

During anodic dissolution of irradiated binary Experimental Breeder Reactor-II fuel, a portion of the electrorefined uranium collects in the underlying cadmium pool. It is periodically recovered by setting up a cell configuration in which the pool is made the anode and uranium is electrodeposited on a solid cathode mandrel. A theoretical model is used to determine the current structure of the liquid cadmium anode. The model is validated by comparing against the measured composition of the cathode deposits. Multinodal simulations are conducted to explain the bell shape of deposits observed with this mode of electrotransport. The simulations also determine the dependence of collection efficiency on the electrical charge passed that is functionally consistent with the experimental data. Finally, a simplified operating map of the electrorefiner is presented that can be used to determine the conditions for growing cathode deposits of target composition.
Optical and thermal characteristics of narrow-ridge quantum-cascade lasers (2008)

Quantum-cascade lasers operating at λ≈3.9μm at room temperature with narrow w≈5μm ridge widths are described. The lateral confinement due to the narrow ridge is similar to the vertical confinement and the resulting beam is circular in cross section with a single TM00 spatial mode. The beam divergence is 46° both parallel and perpendicular to the surface. The beam quality factor along the slow axis is about M2=1.6. The narrow ridges also increase the relative lateral heat dissipation from the active region, resulting in a thermal conductance per unit area of about Gth=380WK−1cm−2 for a 3mm long laser. Maximum average power is obtained with duty cycles between 10% and 30%; in spite of the very narrow ridge, the total average power with thermoelectric cooling exceeds 60mW with a peak power of 460mW. The circularly symmetric beam with very good beam quality suggests essentially zero astigmatism and indicates that these narrow-ridge quantum-cascade lasers are well suited for applications in midinfrared spectroscopy and imaging.
A low-voltage switched-current delta-sigma modulator (1995)

This paper presents the design of a fully differential switched-current delta-sigma modulator using a single 3.3-V power-supply voltage. At system level, we tailor the modulator structure considering the similarity and difference of switched-capacitor and switched-current realizations. At circuit level, we propose a new switched-current memory cell and integrator with improved common mode feedback, without which low power-supply-voltage operation would not be possible. The whole modulator was implemented in a 0.8-/spl mu/m double-metal digital CMOS process. It occupies an active area of 0.53/spl times/0.48 mm/sup 2/ and consumes a current of 0.6 mA from a single 3.3-V power supply. The measured dynamic range is over 10 b.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
L-671,329, a new antifungal agent. I. Fermentation and isolation. (1989)

In screening for new antifungal agents from fungi, a new lipopeptide antifungal agent, L-671,329, similar to echinocandin B, has been isolated from Zalerion arboricola. Studies indicate that L-671,329 is produced under both solid and liquid fermentation conditions.
Identification and Differentiation of <i>Tilletia indica</i> and <i>T. walkeri</i> Using the Polymerase Chain Reaction (2000)

ABSTRACT Karnal bunt of wheat, caused by Tilletia indica, was found in regions of the southwestern United States in 1996. Yield losses due to Karnal bunt are slight, and the greatest threat of Karnal bunt to the U.S. wheat industry is the loss of its export market. Many countries either prohibit or restrict wheat imports from countries with Karnal bunt. In 1997, teliospores morphologically resembling T. indica were isolated from bunted ryegrass seeds and wheat seed washes. Previously developed PCR assays failed to differentiate T. indica from the recently discovered ryegrass pathogen, T. walkeri. The nucleotide sequence of a 2.3 kb region of mitochondrial DNA, previously amplified by PCR only from T. indica, was determined for three isolates of T. indica and three isolates of T. walkeri. There was greater than 99% identity within either the T. indica group or the T. walkeri group of isolates, whereas there was =3% divergence between isolates of these two Tilletia species. Five sets of PCR primers were made specific to T. indica, and three sets were designed specifically for T. walkeri based upon nucleotide differences within the mitochondrial DNA region. In addition, a 212 bp amplicon was developed as a target sequence in a fluorogenic 5' nuclease PCR assay using the TaqMan system for the detection and discrimination of T. indica and T. walkeri.