gebhart/patrepeval huggingface dataset:
<i>MLL</i>-SEPTIN gene fusions in hematological malignancies (2011)

The mixed lineage leukemia (MLL) locus is involved in more than 60 different rearrangements with a remarkably diverse group of fusion partners in approximately 10% of human leukemias. MLL rearrangements include chromosomal translocations, gene internal duplications, chromosome 11q deletions or inversions and MLL gene insertions into other chromosomes, or vice versa. MLL fusion partners can be classified into four distinct categories: nuclear proteins, cytoplasmatic proteins, histone acetyltransferases and septins. Five different septin genes (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) have been identified as MLL fusion partners, giving rise to chimeric fusion proteins in which the N terminus of MLL is fused, in frame, to almost the entire open reading frame of the septin partner gene. The rearranged alleles result from heterogeneous breaks in distinct introns of both MLL and its septin fusion partner, originating distinct gene fusion variants. MLL-SEPTIN rearrangements have been repeatedly identified in de novo and therapy related myeloid neoplasia in both children and adults, and some clinicopathogenetic associations are being uncovered. The fundamental roles of septins in cytokinesis, membrane remodeling and compartmentalization can provide some clues on how abnormalities in the septin cytoskeleton and MLL deregulation could be involved in the pathogenesis of hematological malignancies.
Ascorbic Acid Prevents Blood–Brain Barrier Disruption and Sensory Deficit Caused by Sustained Compression of Primary Somatosensory Cortex (2010)

Transient compression of rat somatosensory cortex has been reported to affect cerebral microvasculature and sensory function simultaneously. However, the effects of long-term cortical compression remain unknown. Here, we investigated whether and to what extent sustained but moderate epidural compression of rat somatosensory cortex impairs somatic sensation and/or cortical microvasculature. Electrophysiological and behavioral tests revealed that sustained compression caused only short-term sensory deficit, particularly at 1 day after injury. Although the diameter of cortical microvessels was coincidentally reduced, no ischemic insult was observed. By measuring Evans Blue and immunoglobulin G extravasation, the blood-brain barrier (BBB) permeability was found to dramatically increase during 1 to 3 days, but this did not lead to brain edema. Furthermore, immunoblotting showed that the BBB component proteins occludin, claudin-5, type IV collagen, and glial fibrillary acidic protein were markedly upregulated in the injured cortex during 1 to 2 weeks when BBB regained integrity. Conversely, treatment of ascorbic acid prevented compression-induced BBB disruption and sensory impairment. Together, these data suggest that sustained compression of the somatosensory cortex compromises BBB integrity and somatic sensation only in the early period. Ascorbic acid may be used therapeutically to modulate cortical compression and/or BBB dysfunction.
Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP) (2012)

A promiscuous UDP-sugar pyrophosphorylase (BLUSP) was cloned from Bifidobacterium longum strain ATCC55813 and used efficiently with a Pasteurella multocida inorganic pyrophosphatase (PmPpA) with or without a monosaccharide 1-kinase for one-pot multienzyme synthesis of UDP-galactose, UDP-glucose, UDP-mannose, and their derivatives. Further chemical diversification of a UDP-mannose derivative resulted in the formation of UDP-N-acetylmannosamine.
Comparison of Root System Development in Two Rice Cultivars During Stress Recovery from Drought and the Plant Traits for Drought Resistance (2001)

SummaryA greenhouse experiment was conducted to compare root system development of two upland rice cultivars, IRAT 13 and Senshou, during recovery from drought stress and to identify the plant traits that confer drought resistance. From 62 days after sowing (62 DAS), drought stress was given for 6 d followed by rewatering for 14 d. Root length density (RLD) and root diameter (thickness) were measured at the end of the stress and rewatering periods. Control plants were well-watered throughout the study. Gultivar IRAT 13 had thicker roots and higher relative RLD (ratio of RLD in drought-stressed plants to that in control plants) than under drought stress, and significantly higher root growth recovery after rewatering cultivar Senshou. Related plant traits such as evapotranspiration (ET), leaf and stem dry weights and weight of senescent leaves (dead leaves) in IRAT 13 were significantly more favorable for drought resistance compared to Senshou.
Cuttings Transport with Foam in Horizontal & Highly-Inclined Wellbores (2003)

Abstract Foams are of considerable interest for annular pressure management in many drilling applications. While foam rheology and hydraulics have been studied in the past, knowledge of cuttings transport with foam is very limited for vertical wells, and even less well understood for horizontal and inclined-well configurations. In this paper, cuttings transport with foam in horizontal and highly-inclined wells is analyzed. Using the principles of mass and linear momentum conservation, a model consisting of three layers (motionless bed – observed in most experiments, moving foam-cuttings mixture and foam free of cuttings) is presented. The model includes seven independent equations and seven unknowns. A computer simulator was developed to solve simultaneously the system of equations for flow velocities, cuttings bed height, slip velocity, the in-situ concentration of flowing cuttings and pressure drop. An extensive experimental program on cuttings transport was conducted using The University of Tulsa Drilling Research Projects' full-scale (8" by 4 ½") flow loop at 70° to 90° inclinations (from vertical). A broad range of annular velocities and cuttings injection rates was investigated using foam qualities of 70% to 90%. Results from the experiments are presented in the form of graphs showing the cuttings bed cross-sectional area and pressure losses vs. foam flow rate. In all experiments, the foam behaved as a pseudo-plastic fluid; foam qualities of 80% and 90% exhibited noticeable wall slip. At a given flow rate and rate of penetration, bed thickness increases with an increase in foam quality. There is little effect of inclination angles in the range of 70°–90°. The experimental data were used to verify results from the simulator. The simulator is capable of estimating bed thickness and pressure drop with an error of less than 20% in most cases.
Estimation of Petrophysical Parameters of Heterogeneous Carbonate Rock Sample with Multi-Scale CT Images (2016)

Abstract The understanding of petrophysical properties is essential for the assessment and exploitation of hydrocarbon reserves. Reservoir rock is one of the main sources used to derive petrophysical properties by laboratory measurements. However, probing complex pore structure and heterogeneity of carbonate rocks are difficult with conventional experimental methods. Digital rock physics (DRP) is able to compute the petrophyscial parameters (e.g. porosity, permeability, elastic modulus) from three dimensional (3D) computed tomography (CT) images, which can make up for some disadvantages of traditional experiments. It also provides an understanding on how the large variations in petrophysical properties are caused by wide variations in pore type, pore shape, and pore interconnectivity. This paper is a case study on analysis of heterogeneity and estimation of petrophysical parameters in a heterogeneous rudstone sample using multi-scale CT images with three resolutions of 39.48 μm/voxel, 1.0357 μm/voxel and 65 nm/voxel. The Back-scattered Electron Image (BSEI) analysis that is used to locate subsamples in low-resolution image for high-resolution CT scan shows the range of pore-throat radius size of this sample is from 0.1μm to 10μm and most pores are under 1μm. The low-resolution images (here resolution of 39.48 μm/voxel and 1.0357 μm/voxel) show a poor pore connectivity. The high-resolution image (65 nm/voxel) provide a more detailed pore structure that contributes to estimation of petrophysical properties. The estimated porosity (21.92%) and absolute permeability (6.54mD) from the high-resolution images are close to the lab measurements (22.7% and 4.9mD), which shows the accuracy of DRP in this particular sample. The relative errors of elastic modulus between the simulation and the measurements are 77.23% and 87.68% for bulk moduli and shear moduli, respectively. The image registration locates the Nano-CT images in the low-resolution image (1.0357 μm/voxel), which better characterize the pore geometry in different 3D image and provide a new way to do the upscaling work. The multi-scale images, the visualization of fluid velocity distribution, the lab measurements, and the simulated values show the heterogeneity of this carbonate sample.
Neural network based feedback linearization control of a servo-hydraulic vehicle suspension system (2011)

Neural network based feedback linearization control of a servo-hydraulic vehicle suspension system This paper presents the design of a neural network based feedback linearization (NNFBL) controller for a two degree-of-freedom (DOF), quarter-car, servo-hydraulic vehicle suspension system. The main objective of the direct adaptive NNFBL controller is to improve the system's ride comfort and handling quality. A feedforward, multi-layer perceptron (MLP) neural network (NN) model that is well suited for control by discrete input-output linearization (NNIOL) is developed using input-output data sets obtained from mathematical model simulation. The NN model is trained using the Levenberg-Marquardt optimization algorithm. The proposed controller is compared with a constant-gain PID controller (based on the Ziegler-Nichols tuning method) during suspension travel setpoint tracking in the presence of deterministic road disturbance. Simulation results demonstrate the superior performance of the proposed direct adaptive NNFBL controller over the generic PID controller in rejecting the deterministic road disturbance. This superior performance is achieved at a much lower control cost within the stipulated constraints.
Monitoring Behavioral Transitions in Cognitive Rehabilitation with Multi-Model, Multi-Window Stream Mining (2010)

This paper describes how quality metrics over stream-mined models can identify potential changes in user goal attainment, as a user learns a personalized emailing system. A sequence of mined models is generated from sequential segments of logged user email commands. When the quality of some models varies significantly from nearby models-as defined by quality metrics-then the user's behavior is flagged as a potentially significant change. This paper describes how this technique works in its application on a case study of cognitive rehabilitation via emailing.
WDDL is Protected against Setup Time Violation Attacks (2009)

In order to protect crypto-systems against side channel attacks various countermeasures have been implemented such as dual-rail logic or masking. Faults attacks are a powerful tool to break some implementations of robust cryptographic algorithms such as AES and DES. Various kind of fault attacks scenarios have been published. However, very few publications available in the public literature detail the practical realization of such attacks. In this paper we present the result of a practical fault attack on AES in WDDL and its comparison with its non-protected equivalent. The practical faults on an FPGA running an AES encrypt or are realized by under-powering it and further exploited using Piret's attack. The results show that WDDL is protected against setup violation attacks by construction because a faulty bit is replaced by a null bit in the cipher text. Therefore, the fault leaks no exploitable information. We also give a theoretical model for the above results. Other references have already studied the potential of fault protection of the resynchronizing gates (delay-insensitive). In this paper, we show that non-resynchronizing gates (hence combinatorial DPL such as WDDL) are natively immune to setup time violation attacks.
Design and Security Simulation of Wi-Fi Networks (2017)

Wireless networks milieu is sprouting into the market, and it is the principal way of accessing the internet. Design and security of these networks for an organization need to be considered to ensure mobility is accomplished. In this study simulation results of 802.1X with flexible authentication via secure tunnelling was performed. Opportunistic key caching which is preferred by many vendors was used transit the session information from the posterior access point to the prior access point to minimize the hand-off latency to allow continuous connectivity to avoid poor network performance. The simulation process was applied throughout the write up of this article without setting up the pricy real lab-test. After the successful modelling of the network, the outcome will be transferred to the real-life environment. The network simulator software was used to illustrate roaming while Cisco Packet Tracer was engaged in the layout design of the wireless nodes. This research applies to network administrators and engineers worldwide to save time and the cost of the network appliances.
Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms (2010)

Knowledge of common genetic variation appropriately reclassifies younger people for type 2 diabetes risk beyond clinical risk factors but not older people.
Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. (1989)

Freshly isolated murine PP B cells were cultured with 10 different cytokines, including IL-1 alpha, IL-2, IL-4, IL-5, IL-6, IL-7, IFN-gamma, TNF-alpha, and TGF-beta, to investigate a possible role for these cytokines in induction of Ig synthesis. Of interest was the finding that only IL-5 and both mouse recombinant (mr) and human recombinant (hr) IL-6 enhanced IgA synthesis. The effect was greater with either mrIL-6 or hrIL-6 than with mrIL-5. IL-6 induced cycling mIgA+ PP B cells to secrete high levels of IgA (approximately 7-fold increase over control). Of importance was the finding that mrIL-6 had little effect on secretion of IgM or IgG by PP B cell cultures. hrIL-6 also increased IgA secretion by PP B cells and this enhancement was abolished by a goat anti-hrIL-6 antiserum. mrIL-6 did not cause B cell proliferation but induced a sharp increase in numbers of B cells secreting IgA. Isotype-switching was not a mechanism for this marked increase in IgA synthesis since mIgA- PP B cells were not induced to secrete IgA by mrIL-6. From these studies we conclude that IL-6 plays an important role in promoting the terminal differentiation of PP B cells to IgA-secreting plasma cells.
Mental Health Mobile Apps: From Infusion to Diffusion in the Mental Health Social System (2015)

The roles of mental health educators and professionals in the diffusion of mental health mobile apps are addressed in this viewpoint article. Mental health mobile apps are emerging technologies that fit under the broad heading of mobile health (mHealth). mHealth, encompassed within electronic health (eHealth), reflects the use of mobile devices for the practice of public health. Well-designed mental health mobile apps that present content in interactive, engaging, and stimulating ways can promote cognitive learning, personal growth, and mental health enhancement. As key influencers in the mental health social system, counselor educators and professional associations may either help or hinder diffusion of beneficial mHealth technologies. As mental health mobile apps move towards ubiquity, research will continue to be conducted. The studies published thus far, combined with the potential of mental health mobile apps for learning and personal growth, offer enough evidence to compel mental health professionals to infuse these technologies into education and practice. Counselor educators and professional associations must use their influential leadership roles to train students and practitioners in how to research, evaluate, and integrate mental health mobile apps into practice. The objectives of this article are to (1) increase awareness of mHealth and mental health mobile apps, (2) demonstrate the potential for continued growth in mental health mobile apps based on technology use and acceptance theory, mHealth organizational initiatives, and evidence about how humans learn, (3) discuss evidence-based benefits of mental health mobile apps, (4) examine the current state of mHealth diffusion in the mental health profession, and (5) offer solutions for impelling innovation diffusion by infusing mental health mobile apps into education, training, and clinical settings. This discussion has implications for counselor educators, mental health practitioners, associations, continuing education providers, and app developers.
Freehand HDR photography with motion compensation (2007)

In theory HDR photography generated from expo-sure sequences is limited to pictures of still scenes preferably taken with the camera mounted on a tri-pod. Current state-of-the-art HDR imaging soft-ware relaxes this limitation by aligning the pictures with afne transformations. However, two pictures cannot be aligned with a single afne transforma-tion if objects in the scene move or the position of the camera changes which causes parallax effects in the image. In this paper, a method for the non-linear align-ment of a picture sequence for HDR imaging is pre-sented. By using techniques for motion detection and compensation, the approach is not only capa-ble to correctly align pictures containing parallax effects, but also able to compensate for the move-ment of objects in the scene. This way, taking free-hand HDR pictures from non-static scenes becomes possible with off-the-shelf digital cameras. 1
Vehicular Collision Avoidance Support System v2 (VCASSv2) by GPS+INS Hybrid Vehicular Positioning Method (2007)

In recent years, researches and developments on ITS are carried out to solve many problems in road traffic. IVC (inter-vehicular communications) is the key technology to realize the next generation ITS. Vehicles install telecommunication equipment, and exchange safety information directly with each other. The authors have developed vehicular collision avoidance support system (VCASS) based on IVC in order to prevent a vehicular accident beforehand. The system grasps the relative locations of vehicles by exchanging the GPS information in each vehicle. Then the system warns drivers if there is a danger of collision. VCASS can drastically reduce the potential accidents of vehicular collisions but causes warning errors and unnecessary warnings. In order to improve the accuracy of VCASS, we propose a new VCASSv2 that introduces GPS+INS hybrid scheme. We evaluate the performance of conventional collision judgment algorithm and the proposed scheme for VCASSv2. We have verified the effectiveness of the new VCASSv2 in typical road environments.
Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes (2018)

Synthetic polymer membranes, critical to diverse energy-efficient separations, are subject to permeability-selectivity trade-offs that decrease their overall efficacy. These trade-offs are due to structural variations (e.g., broad pore size distributions) in both nonporous membranes used for Angstrom-scale separations and porous membranes used for nano to micron-scale separations. Biological membranes utilize well-defined Angstrom-scale pores to provide exceptional transport properties and can be used as inspiration to overcome this trade-off. Here, we present a comprehensive demonstration of such a bioinspired approach based on pillar[5]arene artificial water channels, resulting in artificial water channel-based block copolymer membranes. These membranes have a sharp selectivity profile with a molecular weight cutoff of ~ 500 Da, a size range challenging to achieve with current membranes, while achieving a large improvement in permeability (~65 L m<sup>-2</sup> h<sup>-1</sup> bar<sup>-1</sup> compared with 4-7 L m<sup>-2</sup> h<sup>-1</sup> bar<sup>-1</sup>) over similarly rated commercial membranes.
3D Silicon Photonics Interposer for Tb/s Optical Interconnects in Data Centers with Double-Side Assembled Active Components and Integrated Optical and Electrical Through Silicon Via on SOI (2019)

In this paper, we present the concept, fabrication, process and packaging of a 3D Si photonics interposer. This Si photonics interposer merges passive photonic and electronic functionalities within a single chip. The interposer is populated with active optical and electronic add-ons, which are flip-chip bonded to the interposer using thermo-compression bonding. The interposer itself is then flip-chip bonded to a glass and Si carrier for further testing purposes. This integration concept enables a high connection density (Gb/s/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) by assembling 40Gb/s per channel opto-electrical components on both sides of the interposer. Communication between components on both sides of the interposer is enabled by optical and electrical TSVs with a 3dB bandwidth >28GHz. A single mode photonic layer, designed for 1.55μm wavelength is integrated within the interposer to be used for routing and switching of the optical signals. Main fabrication and packaging steps are described here, together with some demonstrator evaluation results.
A Web recommendation system based on maximum entropy (2005)

In this paper, we propose a Web recommendation system based on a maximum entropy model. Under the maximum entropy principle, multiple sources of knowledge about users' navigational behavior in a Web site can be seamlessly combined to discover usage patterns and to automatically generate the most effective recommendations for new users with similar profiles. In this paper we integrate the knowledge from page-level clickstream statistics about users' past navigations with the aggregate usage patterns discovered through Web usage mining. Our experiment results show that our method can achieve better prediction accuracy when compared to standard recommendation approaches, while providing a better interpretation of Web users' diverse navigational behaviors.
Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. (1994)

About a half of the antierythrocyte autoantibody transgenic (autoAb Tg) mice, in which almost all B cells are detected in the spleen, lymph nodes, and Peyer's patches, but not in the peritoneal cavity, suffer from autoimmune hemolytic anemia. The occurrence of this disease is strongly linked to production of autoAb by activated peritoneal B-1 cells in the Tg mice. In this study, we have shown that oral administration of lipopolysaccharides (LPS) activated B-1 cells in the lamina propria of the gut as well as the peritoneal cavity in the healthy Tg mice and induced the autoimmune symptoms in all the Tg mice. The activation of peritoneal and lamina propria B-1 cells by enteric LPS is found not only in the anti-RBC autoAb Tg mice and normal mice but also in the aly mice which congenitally lack lymph nodes and Peyer's patches. These results suggest that B-1 cells in the two locations may form a common pool independent of Peyer's patches and lymph nodes, and can be activated by enteric thymus-independent antigens or polyclonal activators such as LPS. The induction of autoimmune hemolytic anemia in the Tg mice by enteric LPS through the activation of B-1 cells in the lamina propria of gut and in the peritoneal cavity suggests that B-1 cells and bacterial infection may play a pathogenic role in the onset of autoimmune diseases.