gebhart/patrepeval huggingface dataset:
IBM RISC System/6000: architecture and performance (1991)

The IBM RISC System/6000, a superscalar microprocessor, is presented. The architecture of this processor has its instruction set specifically designed for a superscalar machine containing three independent units-branch, fixed-point, and floating-point. The design also emphasizes high-performance floating-point operations. The design principles are to offer maximum overlap of the three functional units, avoid dead cycles, and define instructions that can (for the most part) be completed at a rate of one per cycle. The branch cycle, fixed- and floating-point units, cache management, and performance are described. Benchmark results are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nonlinear emission from dark anapole modes and route to all-dielectric metamaterial near-field lasers (2016)

By employing ab-initio simulations of Maxwell-Bloch equations with a source of quantum noise, we study a new laser concept based on photonic dark-matter nanostructures that emit only in the near-field, with no far-field radiation pattern.
Diamagnetic Orientation of Polymerized Molecules under High Magnetic Field (1989)

Diamagnetic alignment of polymerized organic molecules is discussed both from the theoretical and experimental points of view. When a number of molecules aggregate with their diamagnetic principal axes along the same direction, the resultant diamagnetic anisotropy energy becomes comparable to the thermal energy and the aggregated molecule can align under a conventional magnetic field, even at room temperatures. Polymerization of fibrin molecules is observed under magnetic fields up to 8 Tesla and considerable alignment is found. Partial alignment is seen even at 1 Tesla which means that blood clotting is influenced by use of the conventional superconducting magnet.
Natarsia tokunagai (Fittkau, 1962) comb. nov. (Diptera, Chironomidae) (1998)

[in Japanese]
Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators (2013)

The role of non-steroidal anti-inflammatory drugs in inflammatory bowel disease is controversial, as they have been implicated in disease aggravation. Different from other cyclooxygenase inhibitors, acetylsalicylic acid (ASA) enhances the formation of anti-inflammatory and proresolution lipoxins derived from arachidonic acid as well as resolvins from omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA). In this study, we examined the effect of ASA on murine dextran sodium sulfate colitis. A mouse magnetic resonance imaging (MRI) protocol and post mortem assessment were used to assess disease severity, and lipid metabolites were measured using liquid chromatography-coupled tandem mass spectrometry. Decreased colitis activity was demonstrated by phenotype and MRI assessment in mice treated with ASA, and confirmed in postmortem analysis. Analysis of lipid mediators showed sustained formation of lipoxin A4 and an increase of DHA-derived 17-hydroxydocosahexaenoic acid (17-HDHA) after treatment with ASA. Furthermore, in vitro experiments in RAW264.7 murine macrophages demonstrated significantly increased phagocytosis activity after incubation with 17-HDHA, supporting its proresolution effect. These results show a protective effect of ASA in a murine colitis model and could give a rationale for a careful reassessment of ASA therapy in patients with inflammatory bowel disease and particularly ulcerative colitis, possibly combined with DHA supplementation.
Quantitative immunoassay for complexes of prostate-specific antigen with alpha2-macroglobulin (1996)

We have developed two ELISAs for quantifying complexes of prostate-specific antigen (PSA) with alpha2-macroglobulin (alpha2M), using partially purified PSA:alpha2M complex as the calibrator. One ELISA was designed to evaluate )SA:alpha2M complex in fluids containing a huge excess of PSA over the amount of complex (semen-derived fluids), the other for use in fluids containing an excess of alpha2M over PSA (blood plasma). The range of the assays was 2-1000 micrograms/L for PSA complexed to alpha2M; the detection limit was 3 micrograms/: Intra- and interassay CVs were 7-13% and 11-17%, respectively, at complexed PSA concentrations of 6-500 micrograms/L. Seminal fluid from healthy men (n = 60) contained 5.2 +/- 2.6 micrograms/L PSA complexed with alpha2M. Prostatic and seminal vesicle fluids contained 6.5 +/- 2.9 ad 0.3 +/- 0.2 mg/L PSA complexed to alpha2M, respectively. When purified PSA was incubated with citrated plasma, between 45% and 65% of the added PSA was recovered as free PSA, whereas approximately 25% formed complexes with alpha2M, 10% complexed with alpha1-antichymotrypsin, and only 0.1-6% was complexed with protein C inhibitor. Of 30 patients with prostate disease, 20 showed detectable plasma PSA:alpha2M complexes; however, the potential diagnostic significance of this complex requires further investigation.
Electrical Control of Urease Activity Immobilized to the Conducting Polymer on the Carbon Felt Electrode (2002)

Abstract The activity of urease varies by its redox reaction. Active urease has an SH group that is essential to exhibit its activity, however, oxidation agents such as quinone compounds can oxidize the SH group in urease and a S–S bond is produced, resulting in the loss of enzyme activity. The reduction potential of cystine was almost the same as that of the recovery of urease activity. In this work, it has been found that the SH group of urease can be oxidized by not only chemical reaction but also by the direct electrode oxidation of urease and the produced S–S bond can be reduced to SH group by chemical and electrode reactions, and the original enzyme activity is recovered. This research shows that the regulation of urease activity is easily possible by changing the electrode potential of the porous carbon felt immobilized urease. The variation of urease activity was monitored by ammonia or carbon dioxide electrode equipped with the urease immobilized carbon felt, and the ammonia or carbon oxide generated from urea can transfer through the carbon felt to reach the each gas permeable membrane. The combination of gas electrode with porous conducting material such as carbon can supply the novel device for the electrochemical investigation of enzyme activity.
External Arguments in Basque (1993)

Williams (1981) proposes that there is a designated argument within the thematic structure of the verb which must be realized external to the VP, in the specifier of a functional phrase (IP). 1 In contrast, Kuroda (1986) and Koopman & Sportiche (1988) among others propose that all the arguments of the verb are realized internal to the VP. 2 We argue that in Basque, all the arguments of the verb are external arguments in the sense of Williams (1981).That is, we propose a third alternative, namely, that all the arguments of the verb are projected external to the VP in the specifier positions of functional phrases and indirectly theta-marked by a functional head.We first discuss the basic properties of a Basque sentence.In section 2, we show that all the arguments in Basque, in particular the absolutive argument, must be external to the VP at S-structure.To this effect, we will discuss Agreement and pro-drop, the morphological structure of the Auxiliary, control and Case and finally wh-movement.We then argue that it is precisely this hypothesis, namely, that all the arguments of the verb must be in specifiers outside the VP at S-structure, which is incompatible with the VP-internal hypothesis.This leads us to propose that all arguments of the verb are external arguments in the sense of Williams (1981).We then propose an account of whmovement and free word order in Basque.We conclude with a discussion of the similarities between the VP-internal and the VP-external hypothesis. 1 We would like to thank participants in the Basque seminar and workshop, in particular, Ken Haie and Itziar Laka for helpful discussions and suggestions.In addition, we have benefited a lot from discussions with Noam Chomsky, Howard Lasnik, Alec Marantz, Jon Ortiz de Urbina, Bernard Oyhargabal, David Pesetsky and Dominique Sportiche.2 There are various versions of the VP-intemal subject hypothesis (Haie 1980, Kitagawa 1986, Speas 1986and Zagona 1982).Our arguments against the VP-internal hypothesis for Basque hold regardless of the particular instantiations of this hypothesis.' An analysis of the contrasts shown in ( 11) and ( 12) is proposed in Laka & Uriagereka (1986) and Uriagereka (1987).' An analysis of the contrasts shown in ( 11) and ( 12) is proposed in Laka & Uriagereka (1986) and Uriagereka (1987).
Modeling Unsteady Boundary Layer Transition on a Curved Plate Under Periodic Unsteady Flow Conditions: Aerodynamic and Heat Transfer Investigations (1999)

A boundary layer transition model is developed that accounts for the effects of periodic unsteady wake flow on the boundary layer transition. To establish the model, comprehensive unsteady boundary layer and heat transfer experimental investigations are conducted. The experiments are performed on a curved plate at zero-streamwise pressure gradient under periodic unsteady wake flow, where the frequency of the periodic unsteady flow is varied. The analysis of the time-dependent velocities, turbulence intensities, and turbulence intermittencies has identified three distinct quantities as primarily responsible for the transition of an unsteady boundary layer. These quantities, which exhibit the basis of the transition model presented in this paper, are: (1) relative intermittency, (2) maximum intermittency, and (3) minimum intermittency. To validate the developed transition model, it is implemented in an existing boundary layer code, and the resulting velocity profiles and the heat transfer coefficients are compared with the experimental data.
Chemical Cleavage at Aspartyl Residues for Protein Identification (2001)

An alternative method to enzymatic digestion for protein identification by mass spectrometry has been developed that is based on chemical cleavage by formic acid. This method was tested on gel-purified apomyoglobin and BSA, as well as unknown proteins that cofractionate with Tyl-virus-like particles from Saccharomyces cerevisiae. Cleavage at aspartyl residues was found to be efficient and specific, and this specificity of cleavage lent itself easily to database searches. Parallel digestions using trypsin were also performed. The formic acid cleavage method generated comparable or better results than tryptic digestion for protein identification.
An integrated approach to achieving high software reliability (2002)

In this paper we address the development, testing, and evaluation schemes for software reliability, and the integration of these schemes into a unified and consistent paradigm. Specifically, techniques and tools for the three software reliability engineering phases are described. The three phases are (1) modeling and analysis, (2) design and implementation, and (3) testing and measurement. In the modeling and analysis phase we describe Markov modeling and fault-tree analysis techniques. We present system-level reliability models based on these techniques, and provide modeling examples for reliability analysis and study. We describe how reliability block diagrams can be constructed for a real-world system for reliability prediction, and how critical components can be identified. We also apply fault tree models to fault tolerant system architectures, and formulate the resulting reliability quantity. Finally, we describe two software tools, SHARPE and UltraSAN, which are available for reliability modeling and analysis purpose.
Leiderschap: emergent en ingebed : toelichting bij Larsson en Lundholm (2016)

Een onderzoek naar "professionals in the lead": hoe doen professionals het als manager? Wanneer hebben ze voordeel dan wel nadeel van hun professionele achtergrond?
Expression and Role of APP Gene in Acute Myeloid Leukemia. (2009)

Abstract Abstract 4691 Introduction Amyloid precursor protein(APP) gene was increasingly expressed in solid tumors, promoted the proliferation of tumor cells and the overexpression of APP was a bad prognostic factor to oral squamous cell carcinoma. However, little has been known about the clinical significance and role of APP in acute myeloid leukemia(AML). Methods The expressions of APP mRNA in 85 AML patients and 20 nonmalignant hematological diseases that worked as control were measured by real-time PCR and the expressions of APP in AML cell lines were examined by real-time PCR and western blot. Small interfering RNAs(siRNAs) targeting APP gene were synthesized and transfected into HL60 cell by lipofectamine2000, after RNAi 24h, 48h and 72h, cell growth of HL60 was measured by trypan blue dye exclusion method and MTT, differentiation was observed by Wright-Giemsa staining, cell cycle was examined by PI/RNase staining, apoptosis induction was analyzed by Annexin V/PI and Hoechst33342 staining; apoptosis-related proteins NF-κB, bcl-2 and Caspase-3 were detected by Western blot after RNAi 48h; sensitivity of HL60 to adrimycin was measured by MTT. Results The expression of APP mRNA among AML subtypes was significantly different(P=0.019), M2 with t(8;21) was the highest expression subtype and M5b was the lowest. APP expression had no significant effect on AML clinical characteristic excepting AML subtypes. kasumi-1 was the highest expression cell in AML cell lines and U937 was the lowest(P<0.05), and the expression of APP in HL60/ADM was significantly lower than HL60(P<0.05). The APP expressions in AML cell lines was in agreement with its expressions in primary AML subtypes. After RNAi 24h, 48h, and 72h, no significant differences in proliferation, differentiation, apoptosis, cell cycle and sensitivity of HL60 to adriamycin were detected between interfering group and control groups. Conclusions The APP mRNA expression in M2 with t(8;21) was high and M5b was low. Down-regulation of APP expression had no significant effect on biological behaviour of HL60 and APP was not tightly related to pathogenesis of AML. Disclosures: No relevant conflicts of interest to declare.
Evaluation of Alkyne‐Modified Isoprenoids as Chemical Reporters of Protein Prenylation (2010)

Protein prenyltransferases catalyze the attachment of C15 (farnesyl) and C20 (geranylgeranyl) groups to proteins at specific sequences localized at or near the C-termini of specific proteins. Determination of the specific protein prenyltransferase substrates affected by the inhibition of these enzymes is critical for enhancing knowledge of the mechanism of such potential drugs. Here, we investigate the utility of alkyne-containing isoprenoid analogs for chemical proteomics experiments by showing that these compounds readily penetrate mammalian cells in culture and become incorporated into proteins that are normally prenylated. Derivatization via Cu(I) catalyzed click reaction with a fluorescent azide reagent allows the proteins to be visualized and their relative levels to be analyzed. Simultaneous treatment of cells with these probes and inhibitors of prenylation reveals decreases in the levels of some but not all of the labeled proteins. Two-dimensional electrophoretic separation of these labeled proteins followed by mass spectrometric analysis allowed several labeled proteins to be unambiguously identified. Docking experiments and density functional theory calculations suggest that the substrate specificity of protein farnesyl transferase may vary depending on whether azide- or alkyne-based isoprenoid analogs is employed. These results demonstrate the utility of alkyne-containing analogs for chemical proteomic applications.
Diagnosis of Sleep Apnoea Using a Mandibular Monitor and Machine Learning Analysis: One-Night Agreement Compared to in-Home Polysomnography (2022)

https://clinicaltrials.gov, identifier NCT04262557.
Foetos: an expert system for fetal assessment (1991)

Assessment of the fetus in a high-risk pregnancy uses a variety of tests for screening and continued detection of in utero compromise. This paper describes Foetos, an expert system designed to help clinical personnel to interpret several fetal assessment tests: fetal biophysical profile, contraction stress test, and nonstress tests. Foetos has been built using the knowledge engineering tool Genie, which adopts a mixed frame- and rule-based approach to represent the clinical knowledge in the field. Foetos includes diagnostic, prognostic, and therapeutic structures, based on heuristic interpretation of such tests and contextual structures which relate interpretation to the overall clinical picture. The results of initial retrospective and prospective program validation are included in the report. These results show a substantial level of agreement between Foetos' recommendations and clinical management. Interpretation of the results indicates that the obstetrical field could be an area of interest for the application of AI techniques.
High-Performance Hybrid-Integrated Silicon Photonic Tunable Laser (2019)

We report a silicon photonic tunable laser for coherent communication, with output power reaching 140 mW across the C-band, linewidth narrower than 80 kHz, SMSR larger than 50 dB, and precise gridless frequency tuning.
Trend analysis of university placement by using machine learning algorithms (2018)

Machine learning is a method of data analysis that automates analytical model building. These models help you to make a trend analysis of university placements data, to predict a placement rate for the students of an upcoming year which will help the university to analyze the performance during placements. Many students look at universities as a means of investment which can help them make a great future by getting placed in good companies and which will relieve their stress and unease from their lives before graduating from the university. The trend will also help in giving the companies reasons as to why they should visit university again and again. Some attributes play the very important role while analyzing the student for e.g. Student’s name, Department, Company, Location and Annual package. So, classification can help you to classify those data and clustering helps to make the clusters department wise. In this paper we have used neural networks to predict the upcoming student placement and got 77% of accuracy while testing were iteration are 1000. Through extensive trend analysis of varies complex data collected from different sources, we can demonstrate that our analysis can provide a good pragmatic solution for future placement of students.
Assessing the Accuracy of Foveal Avascular Zone Measurements Using Optical Coherence Tomography Angiography: Segmentation and Scaling (2017)

Using FAZ measurements as biomarkers for disease progression requires assessing and controlling for different sources of error. Not correcting for ocular magnification can result in significant inaccuracy in FAZ measurements, while choice of segmentation method affects both repeatability and accuracy.
Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial. (2013)

This study, applying a relatively low daily dose, allows identification of those climacteric symptoms which respond particularly well to supplementation with Pycnogenol.
Loss of Heterozygosity in Childhood Acute Lymphoblastic Leukemia Detected by Genome-Wide Microarray Single Nucleotide Polymorphism Analysis (2005)

Loss of heterozygosity (LOH) is detectable in many forms of malignancy, including leukemia, using techniques such as microsatellite analysis and comparative genomic hybridization. However, these techniques are laborious and require the use of relatively large amounts of DNA if the whole genome is to be examined. Here we describe the use of oligonucleotide microarrays to characterize single nucleotide polymorphisms (SNPs) in lymphoblasts isolated from children with acute lymphoblastic leukemia for the pan-genomic mapping of LOH with a resolution of 100 to 200 kb. Results were compared with DNA obtained during remission and on relapse. Abnormalities were seen in 8 of 10 cases. The two cases with no abnormalities and one case that showed identical changes at relapse and presentation remain in remission 1 to 9 years following retreatment. The remaining seven patients died following relapse. In four cases, LOH was only detectable at relapse suggesting that progressive LOH may be a cause of disease progression and/or drug resistance. This was supported by detailed analysis of one case in which LOH involving the glucocorticoid receptor was associated with mutation of the remaining allele. The most frequent abnormality detected involved chromosome 9p. In each of the four cases where this was observed LOH included the INK4 locus. In three of the four cases, INK4 loss was only observed at relapse, suggesting that this abnormality may be commonly associated with treatment failure. These observations show that SNP array analysis is a powerful new tool for the analysis of allelic imbalance in leukemic blasts.
Hairy Cell Leukemia (1978)

We studied the clinical and laboratory characteristics of 71 patients with hairy cell leukemia to ascertain whether prognostic factors important for the therapy of the disease existed. Granulocytopenia of less than 500/mu 1 was associated with the occurrence of a serious infection in 46% of the patients, compared to 19% of patients whose absolute granulocyte count was greater than 500/mu 1 (P less than 0.05). In most patients with symptoms of thrombocytopenia or leukopenia, splenectomy led to improved blood counts. Patients treated with splenectomy only had a significantly longer survival than those treated with steroids only (P less than 0.05). A group of patients who were slightly older and had minimal splenomegaly and few hairy cells in the peripheral blood did well without therapeutic intervention. Twenty-four patients have died, 16 of an infectious process. The actuarial survival for the group is 51% at 4 years, and there has been no change subsequently.
An Osteoconductive, Osteoinductive, and Osteogenic Tissue-Engineered Product for Trauma and Orthopaedic Surgery: How Far Are We? (2011)

The management of large bone defects due to trauma, degenerative disease, congenital deformities, and tumor resection remains a complex issue for the orthopaedic reconstructive surgeons. The requirement is for an ideal bone replacement which is osteoconductive, osteoinductive, and osteogenic. Autologous bone grafts are still considered the gold standard for reconstruction of bone defects, but donor site morbidity and size limitations are major concern. The use of bioartificial bone tissues may help to overcome these problems. The reconstruction of large volume defects remains a challenge despite the success of reconstruction of small-to-moderate-sized bone defects using engineered bone tissues. The aim of this paper is to understand the principles of tissue engineering of bone and its clinical applications in reconstructive surgery.
Transient visual changes associated with repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in cases of major depression (2006)

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