gebhart/patrepeval huggingface dataset:
Code design for lossless multiterminal networks (2004)

This paper considers a general multiterminal (MT) system, which consists of L encoders and P decoders. Let X/sub 1/,..., X/sub L/ be memoryless, uniform, correlated random binary vectors of length n, and let x/sub 1/,..., x/sub L/ denote their realizations. Let further /spl Sigma/ = {1,...,L}. The i-th encoder compresses X/sub i/ independently from other encoders. The j-th decoder receives the bitstreams from a set of encoders /spl Sigma//sub j//spl sube/ /spl Sigma/ and jointly decodes them. It should reconstruct the received source messages with arbitrarily small probability of error. To construct a practical coding scheme for this network, we exploit the fact that such a network can be split into P subnetworks, each being regarded as a Slepian-Wolf (SW) coding system with multiple sources. This SW subnetwork consists of a decoder which receives encodings of all X/sub k/'s such that k/spl isin//spl Sigma//sub sw//spl sube//spl Sigma/ and attempts to reconstruct them perfectly. Based on (V. Stankovic et al. 2004), we first provide a code design for this setting, and then extend it to the general case.
Update on Treatment Recommendations From the Fourth International Workshop on Waldenström's Macroglobulinemia (2008)

Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder characterized by lymphoplasmacytic bone marrow infiltration along with an immunoglobulin M (IgM) monoclonal gammopathy. Patients with disease-related cytopenias, bulky adenopathy or organomegaly, symptomatic hyperviscosity, severe neuropathy, amyloidosis, cryoglobulinemia, cold agglutinin disease, or evidence of disease transformation should be considered for immediate therapy. Initiation of therapy should not be based on serum IgM levels alone, and asymptomatic patients should be observed. Individual patient considerations should be considered when deciding on a first-line agent including the presence of cytopenias, need for rapid disease control, age, and candidacy for autologous transplantation. Therapeutic outcomes should be evaluated using updated criteria. As part of the Fourth International Workshop on Waldenström's Macroglobulinemia, a consensus panel updated its recommendations on both first-line and salvage therapy in view of recently published and ongoing clinical trials. The panel considered encouraging results from recent studies of first-line combinations such as rituximab with nucleoside analogs with or without alkylating agents or with cyclophosphamide-based therapies (eg, cyclophosphamide, doxorubicin, vincristine, and prednisone or cyclophosphamide and dexamethasone) or the combination of rituximab with thalidomide. Such therapeutic approaches are likely to yield responses at least as good as, if not better than, monotherapy with any of the alkylating agents, nucleoside analogs, or rituximab. In the salvage setting, reuse of a first-line regimen or use of a different regimen should be considered along with bortezomib, alemtuzumab, autologous transplantation, and, in selected circumstances, allogeneic transplantation. Finally, the panel reaffirmed its encouragement of the active enrollment of patients with WM onto innovative clinical trials whenever possible.
Dynamic Load Balancing and Reactive Power Compensation Switch Embedded in Power Meters (2016)

This brief proposes a dynamic intelligent load balancing and reactive power compensation switch plugin for power meters and a smart scalable system architecture applicable as an add-on to the existing power distribution networks. The load-balancing module will improve the load balance in a network and thus decrease power losses, whereas the distributed reactive power compensator will decrease the total reactive power. The novel approach is presented from its IT/networks perspective as well as from the physical layer with oscilloscope measurements and time analysis of the phase-swapping event.
Novel Standard CMOS Detector using Majority Current for guiding Photo-Generated Electrons towards Detecting Junctions (2005)

A novel photo-detector is demonstrated using a majority current to drive photogenerated minority carriers from deep within the substrate towards a detecting junction. This improves detector sensitivity and speed and allows obtaining simultaneously a large sensitive area and a small detector capacitance, enhancing output signal to noise ratio and/or speed of attached readout circuits. When the applied current is modulated, a very efficient photonic mixer can be conceived, useful as pixel for Time-Of-Flight 3D image sensing. Measurement results in standard CMOS are presented showing an infrared responsivity of 0.32 A/W and a demodulation efficiency of over 99%.
Sign language translation based on syntactic and semantic analysis (1994)

Abstract The prototype sign language translation system described herein interprets Japanese sign language to verbal Japanese language. Since sign language has a unique morphology and syntax, the sign language translation system requires linguistic translation after recognition of the input symbols. One of the main difficulties in translation is a result of the insufficiency of syntactic markers in the input information. In Japanese sign language, input is represented as a sequence of important words. In our method, semantic dependency analysis based on case frame grammar is carried out to complement the lack of information such as postpositions. Then, rule‐based rephrasing is executed to obtain natural verbal language. This scheme contributes both flexibility and ease of maintenance to the translation system. A prototype sign language translation system was implemented and tested using 123 sentences extracted from a sign language textbook. Experimental results indicate that 76 percent of the sentences can be translated correctly if they have no recognition error in input sentence. However, if a recognition error occurs, the experiment indicates that the translation will become highly ambiguous. Therefore, the capability for rejecting incorrect sentences is very important, along with the capability for translating correct input sentences. Future issues include incorporation of unused information, such as facial expression, spatial information and contexts in sign language to improve translation accuracy.
Synthesis, Physico-Chemical Properties and Immunoadjuvant Activity of Water-Soluble Phosphazene Polyacids (1998)

Mixed-substituted polyphosphazenes containing carboxylic acid and alkyl ether side groups were synthesized and characterized. Physicochemical properties of phosphazene polyacids in aqueous solutions were investigated as a function of copolymer structure and composition. The immunoadjuvant activity of polyphosphazenes was evaluated by studying the effect of copolymers on the immunogenicity of the influenza virus in mice. Synthesized polyphosphazenes demonstrated the ability to enhance the immune response as compared to the levels elicited by the vaccine alone.
Cost Reduction of Injection Tests for Under-Pressured Reservoirs (1993)

Abstract A new method for performing reduced cost injection/falloff tests in under-pressured reservoirs has been developed at the GRI sponsored Rock Creek research site. The new method referred to as the "Tank Test" uses gravity drainage from a water storage tank to inject water into the reservoir. The primary advantages of Tank Test over the traditional injection/falloff tests are reduced costs and improved test results. The tank test eliminates the need for expensive pumping equipment and the manpower required for manual pump rate adjustments. Further cost savings can also be made by using gauges intended for ground water monitoring in place of oil field gauges when downhole shutin is not required. The low cost of the Tank Test allows longer duration tests to be economically performed so that the radius of investigation of a test is extended. The Tank Test also reduces the possibility of fracturing the reservoir during the injection portion of the test which is a common problem when testing shallow low permeability reservoirs. This paper describes the circumstances under which the Tank Test is most applicable, the equipment that is required and how to perform the test. The paper presents results of field tests performed on coal seams and a test performed on an Antrim Shale well. A simple Tank Test design procedure is also provided.
Long-term safety and efficacy study of adapalene 0.3% gel. (2008)

The efficacy and safety of adapalene 0.1% gel in the treatment of acne vulgaris has been demonstrated in multiple controlled clinical trials. A higher concentration formulation, adapalene 0.3% gel, has been developed to provide a broader range of treatment options for acne management. Phase 3 clinical studies have demonstrated the superior efficacy of adapalene 0.3% gel compared to adapalene 0.1% gel and its vehicle at the end of a 12-week treatment period. The goal of this study was to evaluate the long-term safety of adapalene 0.3% gel in subjects treated once daily for 52 weeks, with a secondary objective to evaluate long-term efficacy. Subjects 12 years of age or older (N=551) with acne vulgaris participated in a multicenter, open-label study of the long-term (up to 52 weeks) efficacy and safety of once-daily applications of adapalene 0.3% gel. Of those enrolled, 167 subjects completed 12 months of treatment. Expected signs and symptoms of local cutaneous irritation (erythema, dryness, scaling, and stinging/burning) were mostly mild or moderate, with mean tolerability scores below 1 (mild) at all time points for the parameters assessed. Treatment-related, dermatologic adverse events were experienced by 21% of subjects and dry skin, skin discomfort, and scaling were reported by 10.5%, 8.3% and 3.3% of subjects, respectively. Most of the adverse events reported occurred in the first quarter of treatment. Adverse events were mostly mild to moderate in severity. Subjects treated with adapalene 0.3% gel for 52 weeks achieved a >75% median reduction in total, inflammatory, and noninflammatory lesions in this open-label study by the end of the treatment period. Adapalene 0.3% gel was safe and effective in the long-term (up to 1 year) treatment of subjects with acne vulgaris.
Polymer Acid Doped Polyaniline Is Electrochemically Stable Beyond pH 9 (2008)

We report the pH dependence of the electrochemical redox behavior of polyaniline (PANI) that is template synthesized with poly(2-acrylamido-2-methyl-1-propanesulfonic acid), PAAMPSA. Cyclic voltammetry and spectroelectrochemistry were used to assess the oxidation and protonation states of PANI−PAAMPSA. Stable and reversible pernigraniline−emeraldine−leucoemeraldine transitions extend beyond pH 7. Direct pernigraniline−leucoemeraldine transitions dominate in alkaline conditions; these transitions are stable and reversible between 7 and 10, extending the pH stability of PANI well beyond those previously reported.
Optimal input design for indentation-based rapid broadband nanomechanical spectroscopy: Poly(dimethylsiloxane) example (2011)

This article presents an optimal input design approach to achieve rapid broadband nanomechanical measurements of soft materials using the indentation-based method. The indentation-based nanomechanical measurement provides unique quantifications of material properties at specified locations. The measurements, however, are currently too slow in time and too narrow in frequency (range) to characterize time-elapsing material properties during dynamic evolutions (e.g., the rapid-stage of the crystallization process of polymers). Such limits exist because the input force profiles used in current approaches cannot rapidly excite broadband nanomechanical properties of materials. In this article, we develop an optimal-input design approach to tackle these challenges. Particularly, an input force profile with discrete spectrum is optimized to maximize the Fisher information matrix of the linear compliance model of the soft material. Both simulation and experimental results on a PDMS sample are presented to illustrate the need for optimal input design, and its efficacy in probe-based nanomechanical property measurements.
Enhanced Detection of Paramagnetic Contrast Agents in Magnetic Resonance Images Via Phase Image Cross-Correlation Analysis (2006)

Metal-ion based magnetic resonance imaging (MRI) contrast agents can be used to non-invasively track cells, target specific molecules, and watch gene expression in vivo. However, it is often difficult to detect and interpret the subtle image contrast changes produced by these agents if the biodistribution is not known a priori. Sensitive post-processing methods are needed to help identify localized accumulations of contrast agent and to minimize false positives and negatives. Towards these goals, we apply image cross-correlation methods to MRI phase images to highlight the characteristic magnetic susceptibility pattern created by magnetic dipoles in a magnetic field. We show that this method is very effective in highlighting localized paramagnetic deposits. We investigate the detection limits of this cross-correlation method, and we find that it can be used even for images with a very low signal-to-noise ratio (< 4). This method can be used alongside existing magnitude MRI methods, requires no extra scan time, and can be applied retrospectively to previously acquired data.
Model Driven Development for Business Performance Management (2006)

Business process integration and monitoring provides an invaluable means for an enterprise to adapt to changing conditions. However, developing such applications using traditional methods is challenging because of the intrinsic complexity of integrating large-scale business processes and existing applications. Model Driven Development™ (MDD™) is an approach to developing applications—from domain-specific models to platform-sensitive models—that bridges the gap between business processes and information technology. We describe the MDD framework and methodology used to create the IBM Business Performance Management (BPM) solution. We describe how we apply model-driven techniques to BPM and present a scenario from a pilot project in which these techniques were applied. Technical details on models and transformation are presented. Our framework uses and extends the IBM business observation metamodel and introduces a data warehouse metamodel and other platform-specific and transformational models. We discuss our lessons learned and present the general guidelines for using MDD to develop enterprise-scale applications.
Cancelable iris biometric (2008)

A person only has two irises - if his pattern is stolen he quickly runs out of alternatives. Thus methods that protect the true iris pattern need to be adopted in practical biometric applications. In particular, it is desirable to have a system that can generate a new unique pattern if the one being used is lost, or generate different unique patterns for different applications to prevent cross-matching. For backwards compatibility, these patterns should look like plausible irises so they can be handled with the same processing tools. However, they should also non-invertibly hide the true biometric so it is never exposed, or even stored. In this paper four such ldquocancelablerdquo biometric methods are proposed that work with conventional iris recognition systems, either at the unwrapped image level or at the binary iris code level.
First-in-Human Study in Healthy Subjects with the Noncytotoxic Monoclonal Antibody OSE-127, a Strict Antagonist of IL-7Rα (2023)

OSE-127 is a humanized mAb targeting the IL-7Rα-chain (CD127), under development for inflammatory and autoimmune disease treatment. It is a strict antagonist of the IL-7R pathway, is not internalized by target cells, and is noncytotoxic. In this work, a first-in-human, phase I, randomized, double-blind, placebo-controlled, single-center study was carried out to determine the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of OSE-127 administration. Sixty-three healthy subjects were randomly assigned to nine groups: six single ascending dose groups with i.v. administration (0.002-10 mg/kg), a single s.c. treatment group (1 mg/kg), and two double i.v. injection groups (6 or 10 mg/kg). Subjects were followed during <146 d. OSE-127's pharmacokinetic half-life after a single dose increased from 4.6 (1 mg/kg) to 11.7 d (10 mg/kg) and, after a second dose, from 12.5 (6 mg/kg) to 16.25 d (10 mg/kg). Receptor occupancy was ≥95% at doses ≥0.02 mg/kg, and this saturation level was maintained >100 d after two i.v. infusions at 10 mg/kg. IL-7 consumption was inhibited by OSE-127 administration, as demonstrated by a decreased IL-7 pathway gene signature in peripheral blood cells and by ex vivo T lymphocyte restimulation experiments. OSE-127 was well tolerated, with no evidence of cytokine-release syndrome and no significant alteration of blood lymphocyte counts or subset populations. Altogether, the observed lack of significant lymphopenia or serious adverse events, concomitant with the dose-dependent inhibition of IL-7 consumption by target cells, highlights that OSE-127 may show clinical activity in IL-7R pathway-involved diseases.
Chitin degradation potential and whole-genome sequence of Streptomyces diastaticus strain CS1801 (2020)

The aim of this study was to evaluate the chitin degradation potential and whole-genome sequence of Streptomyces diastaticus strain CS1801, which had been screened out in our previous work. The results of fermentation revealed that CS1801 can convert the chitin derived from crab shells, colloidal chitin and N-acetylglucosamine to chitooligosaccharide. Additional genome-wide analysis of CS1801 was also performed to explore the genomic basis for chitin degradation. The results showed that CS1801 possesses a chromosome with 5,611,479 bp (73% GC) and a plasmid with 1,388,284 bp (73% GC). The CS1801 genome consists of 7584 protein-coding genes, 90 tRNA and 21 rRNA operons. In addition, the results of genomic CAZyme analysis indicated that CS1801 comprises 103 glycoside hydrolase family genes, which could regulate the glycoside hydrolases that contribute to chitin degradation. The whole-genome information of CS1801 could highlight the mechanism underlying the chitin degradation activity of CS1801, strongly indicating that CS1801 is characterized by a substantial number of genes encoding chitinases and the complete metabolic pathway of chitin, conferring CS1801 with promising potential applicability in chitooligosaccharide production.
<i>Survivin</i>-Responsive Conditionally Replicating Adenovirus Exhibits Cancer-Specific and Efficient Viral Replication (2005)

Although a conditionally replicating adenovirus (CRA) exhibiting cancer-selective replication and induction of cell death is an innovative potential anticancer agent, current imperfections in cancer specificity and efficient viral replication limit the usefulness of this technique. Here, we constructed survivin-responsive CRAs (Surv.CRAs), in which expression of the wild-type or mutant adenoviral early region 1A (E1A) gene is regulated by the promoter of survivin, a new member of the inhibitor of apoptosis gene family. We explored the cancer specificity and effectiveness of viral replication of Surv.CRAs, evaluating their potential as a treatment for cancer. The survivin promoter was strongly activated in all cancers examined at levels similar to or even higher than those seen for representative strong promoters; in contrast, low activity was observed in normal cells. Surv.CRAs efficiently replicated and potently induced cell death in most types of cancer. In contrast, minimal viral replication in normal cells did not induce any detectable cytotoxicity. A single injection of Surv.CRAs into a preestablished tumor expressing survivin, even at relatively low levels, induced significant tumor death and inhibition of tumor growth. Furthermore, Surv.CRAs were superior to telomerase-dependent CRAs, one of the most effective CRAs that have been examined to date, both in terms of cancer specificity and efficiency. Thus, Surv.CRAs are an attractive potential anticancer agent that could effectively and specifically treat a variety of cancers.
Effect of additives on the thermolysis of ammonia borane (2007)

Ammonia borane (AB) is a very attractive hydrogen storage material with a high gravimetric (196 gm/ H2 kg-1) and volumetric density (145 gm/ H2 liter-1) of hydrogen. Hydrogen release from AB in solution, catalyzed with acids and or metal catalysts, have impressive rates [1-5] however these dissolved AB systems will have difficulty meeting the long term DOE targets if they can not be stabilized in concentrated form [6]. One alternative is neat AB (solid or liquid) releasing >2 equivalents of H2 shows promise to meet the long-term DOE targets if the rates of hydrogen release are sufficient at moderate temperatures. Ammonia borane, formed by a dative bond between the non-bonding electron pair of ammonia with the empty p-orbital of borane (H3NBH3) is a molecular crystal formed by a hydrogen bonding network of dihydrogen bonds. Amorphous powder can be compressed into a pellet of comparable density to the crystal packing density (0.74 gm/cc). Support for this work was provided through the DOE center of Excellence for Chemical Hydrogen Storage of the Hydrogen Program at the U.S. Department of Energy. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.
MagicPhotobook (2009)

Computer-assisted photo album creation continues to be a challenging application as it requires integrated technical solutions to many difficult problems. Effective solutions must leverage both design knowledge and image understanding algorithms to automate time-consuming tasks like image selection, grouping, cropping, layout and background selection. At the same time, they should allow the user to cater to personal tastes by fine-tuning aspects of album appearance. MagicPhotobook is a photobook authoring system that takes steps in these directions by providing advances over prior solutions in the following areas: automatic image selection and theme-based image grouping; dynamic page layout; automatic cropping; automatic background selection; design-preserving background artwork transformation; and a simple yet powerful user interface for personalization.
Analytical Validation of a New Enzymatic and Automatable Method for d-Xylose Measurement in Human Urine Samples (2017)

Hypolactasia, or intestinal lactase deficiency, affects more than half of the world population. Currently, xylose quantification in urine after gaxilose oral administration for the noninvasive diagnosis of hypolactasia is performed with the hand-operated nonautomatable phloroglucinol reaction. This work demonstrates that a new enzymatic xylose quantification method, based on the activity of xylose dehydrogenase from <i>Caulobacter crescentus</i>, represents an excellent alternative to the manual phloroglucinol reaction. The new method is automatable and facilitates the use of the gaxilose test for hypolactasia diagnosis in the clinical practice. The analytical validation of the new technique was performed in three different autoanalyzers, using buffer or urine samples spiked with different xylose concentrations. For the comparison between the phloroglucinol and the enzymatic assays, 224 urine samples of patients to whom the gaxilose test had been prescribed were assayed by both methods. A mean bias of -16.08 mg of xylose was observed when comparing the results obtained by both techniques. After adjusting the cut-off of the enzymatic method to 19.18 mg of xylose, the Kappa coefficient was found to be 0.9531, indicating an excellent level of agreement between both analytical procedures. This new assay represents the first automatable enzymatic technique validated for xylose quantification in urine.