gebhart/patrepeval huggingface dataset:
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism (2008)

Cdc42, a member of Rho GTPases family, is involved in the regulation of several cellular functions, such as rearrangement of actin cytoskeleton, membrane trafficking, cell-cycle progression, and transcriptional regulation. Aberrant expression or activity of Cdc42 has been reported in several tumours. Here, the specific role of Cdc42 in development and progression of colorectal cancer was analyzed through microarrays technology. A comparative analysis of Cdc42 overexpressing cells versus cells with decreased Cdc42 levels through siRNA revealed that Cdc42 overexpression down-regulated the potential tumour suppressor gene ID4. Results were validated by quantitative RT-PCR and the methylation status of the specific promoter, analyzed. Methylation-specific PCR and bisulfite sequencing PCR analysis revealed that Cdc42 induced the methylation of the CpG island of the ID4 promoter. Colorectal adenocarcinoma samples were compared with the corresponding adjacent normal tissue of the same patient in order to determine specific gene expression levels. The downregulation of ID4 by Cdc42 was also found of relevance in colorectal adenocarcinoma biopsies. Cdc42 was found to be overexpressed with high incidence (60%) in colorectal cancer samples, and this expression was associated with silencing of ID4 with statistical significance (p<0.05). Cdc42 may have a role in the development of colon cancer. Furthermore, inhibition of Cdc42 activity may have a direct impact in the management of colorectal cancer.
Contrastive-center loss for deep neural networks (2017)

The deep convolutional neural network(CNN) has significantly raised the performance of image classification and face recognition. Softmax is usually used as supervision, but it only penalizes the classification loss. In this paper, we propose a novel auxiliary supervision signal called contrastivecenter loss, which can further enhance the discriminative power of the features, for it learns a class center for each class. The proposed contrastive-center loss simultaneously considers intra-class compactness and inter-class separability, by penalizing the contrastive values between: (1)the distances of training samples to their corresponding class centers, and (2)the sum of the distances of training samples to their non-corresponding class centers. Experiments on different datasets demonstrate the effectiveness of contrastive-center loss.
Efficient parallel kNN joins for large data in MapReduce (2012)

In data mining applications and spatial and multimedia databases, a useful tool is the kNN join, which is to produce the k nearest neighbors (NN), from a dataset S, of every point in a dataset R. Since it involves both the join and the NN search, performing kNN joins efficiently is a challenging task. Meanwhile, applications continue to witness a quick (exponential in some cases) increase in the amount of data to be processed. A popular model nowadays for large-scale data processing is the shared-nothing cluster on a number of commodity machines using MapReduce [6]. Hence, how to execute kNN joins efficiently on large data that are stored in a MapReduce cluster is an intriguing problem that meets many practical needs. This work proposes novel (exact and approximate) algorithms in MapReduce to perform efficient parallel kNN joins on large data. We demonstrate our ideas using Hadoop. Extensive experiments in large real and synthetic datasets, with tens or hundreds of millions of records in both R and S and up to 30 dimensions, have demonstrated the efficiency, effectiveness, and scalability of our methods.
Calamatic liquid crystal blends for organic photovoltaics (2008)

Four different perylene-based electron-acceptors having similar electron affinities, but different thermotropic phases are blended with nematic liquid crystalline electron-donors with a fluorene-thiophene structure to form single layer photovoltaic devices. Best results are obtained when the nematic donor is mixed with an amorphous acceptor to give a supercooled nematic glass at room temperature. Atomic force microscopy operating in the phase contrast mode reveals phase separation on a nanometer scale with a broad distribution of domain sizes peaking at 26 nm. We correlate the morphology of the different blends with the performance of the photovoltaic devices. Power conversion efficiencies up to 0.9 % are obtained with excitation at 470 nm.
Basics on Emulsion Technologies Were Reviewed from the Following Viewpoints (2010)

乳化技術の基礎について以下の5つの視点から解説を行った。(1)エマルションの型と種類の定義およびエマルション，ナノエマルション，マイクロエマルションの違い。(2)調製法の分類と一般的なエマルション調製法。(3)エマルション崩壊のパターンと乳化安定化理論。(4)エマルションと相図：エマルション，マイクロエマルションの状態および効率の良い乳化と可溶化の理解。(5)微細なエマルションの調製のための最近の乳化技術とその機構のまとめ。
Cesium Removal Demonstration Using Selected Actual Waste Samples from the Hanford Reservation Tank Farm (2006)

Abstract Approximately 40 million curies of Cs‐137 are currently contained in High Level Waste stored in 177 underground storage tanks at the Hanford Nuclear Reservation near Richland, Washington. A series of actual waste, small‐scale column tests were performed to evaluate the performance of a selected ion exchange resin for cesium removal from a range of planned feed streams. These tests demonstrated that the selected cationic resin–SuperLig 644®‐has more than adequate resin capacity to treat each of three potential feed streams. Furthermore, tests indicate an acceptable mass transfer zone for each of the three types of feed material, and that the elution of the resin can be accommodated within the design criteria for the proposed Waste Treatment Plant.
Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling (2007)

We have previously shown that mouse embryonic stem (ES) cells transplanted following myocardial infarction (MI) differentiate into the major cell types in the heart and improve cardiac function. However, the extent of regeneration was relatively meager compared with the observed functional improvement. Therefore, we hypothesize that mechanisms in addition to regeneration contribute to the functional improvement from ES cell therapy. In this study, we examined the effect of mouse ES cells transplanted post-MI on cardiac apoptosis, fibrosis, and hypertrophy. MI was produced by left coronary artery ligation in C57BL/6 mice. Two different mouse ES cell lines, expressing enhanced green fluorescent protein and beta-galactosidase, respectively, were tested. Post-MI intramyocardial injection of 3 x 10(4) ES cells was compared with injection of medium alone. Terminal deoxynucleotidyl nick end labeling (TUNEL), immunofluorescence, and histology were used to examine the effect of transplanted ES cells on apoptosis, fibrosis, and hypertrophy. Two weeks post-MI, ES cell-transplanted hearts exhibited a significant decrease in TUNEL-stained nuclei (mean +/- SE; MI+medium = 12 +/- 1.5%; MI+ES cells = 6.6 +/- 1%, P < 0.05). TUNEL-positive nuclei were confirmed to be apoptotic by colabeling with a caspase-3 antibody. Cardiac fibrosis was 57% less in the MI+ES cell group compared with the MI + medium group (P < 0.05) as shown with Masson's trichrome staining. Picrosirius red staining confirmed a decreased amount of collagen present in the MI+ES cell group. Cardiomyocyte hypertrophy was significantly decreased following ES cell transplantation compared with medium control animals. In conclusion, transplanted mouse ES cells in the infarcted heart inhibit apoptosis, fibrosis, and hypertrophy, thereby reducing adverse remodeling.
Nonspherical Colloidal Crystals Fabricated by the Thermal Pressing of Colloidal Crystal Chips (2005)

Nonspherical colloids and their ordered arrays may be more attractive in applications such as photonic crystals than their spherical counterparts because of their lower symmetries, although such structures are difficult to achieve. In this letter, we describe the fabrication and characterization of colloidal crystals constructed from nonspherical polyhedrons. We fabricated such nonspherical colloidal crystals by pressing spherical polymer colloidal crystal chips at a temperature slightly lower than the glass-transition temperature (T(g)) of these polymer colloids. During this process, the polymer microspheres were distinctively transformed into polyhedrons according to their crystal structures, whereas the long-range order of the 3D lattice was essentially preserved. Because a working temperature lower than T(g) effectively prevented the colloidal crystals from fusing into films, the spherical colloidal crystals were transformed greatly under pressure, which lead to obvious change in the optical properties of colloidal crystals. Besides their special symmetry and optical properties, these nonspherical colloidal crystals can be used as templates for 2D or 3D structures of special symmetry, such as 2D nano-networks. We anticipate that this fabrication technique for nonspherical colloidal crystals can also be extended to nonspherical porous materials.
소형 표면 플라즈몬 공명 센서와 이합체 구조를 가진 SAM을 이용한 CRP검출 (2010)

The detection of C-reactive protein(CRP) using self-assembled monolayer(SAM) was investigated by a portable surface plasmon resonance(SPR) sensor system. The CRP is a biomarker for the possible cardiovascular disease. The SAM was formed on gold(Au) surface to anchor the monoclonal antibody of CRP(anti-CRP) for detection of CRP. Sequence injection of the anti-CRP and bovine serum albumin(BSA) into the sensor system has been carried out immobilize the antibody and to prevent non-specific binding. The portable SPR system has two flow channels: one for the sample measurements and the other for the reference. The output SPR signal was increased with the injection of the anti-CRP, BSA and CRP due to binding of the proteins on the sensor chip. The valid output SPR signal was linearly related to the critical range of the CRP concentration. The experimental results showed the feasibility of the portable SPR system with newly developed SAM to diagnose a risk of the future cardiovascular events.
Performance improvement of continuous-variable quantum key distribution via photon subtraction (2013)

It has been found that non-Gaussian operations can be applied to increase and distill entanglement between Gaussian entangled states. We propose here a method to improve the performance of entanglement-based (EB) continuous-variable quantum-key-distribution protocol by using the non-Gaussian operation, in particular, the subtraction operation, which can be implemented under current technology easily. Security analysis shows that the subtraction operation can well increase the secure distance and tolerable excess noise of the EB scheme and also the corresponding prepare-and-measure scheme.
Mn<sup>3+</sup> in Trigonal Bipyramidal Coordination: A New Blue Chromophore (2009)

We show that trivalent manganese, Mn(3+), imparts an intense blue color to oxides when it is introduced at dilution in trigonal bipyramidal coordination. Our optical measurements and first-principles density functional theory calculations indicate that the blue color results from an intense absorption in the red/green region. This absorption is due in turn to a symmetry-allowed optical transition between the valence-band maximum, composed of Mn 3d(x(2)-y(2),xy) states strongly hybridized with O 2p(x,y) states, and the narrow Mn 3d(z(2))-based conduction-band minimum. We begin by demonstrating and explaining the effect using a well-defined prototype system: the hexagonal YMnO(3)-YInO(3) solid solution. We then show that the behavior is a general feature of diluted Mn(3+) in this coordination environment.
Windows XP Home Edition: The Missing Manual (2nd Edition) (2004)

Windows XP Home Edition offers dozens of new features for consumers: an elegant user interface, drag-and-drop CD burning, and powerful ways to view and manage digital photos and music, among other features. With the release of Service Pack 2 (SP2), Windows XP now provides better protection against viruses, worms, and malicious hackers. But it still comes without a single page of printed instructions. Fortunately, the new edition of Windows XP Home Edition: The Missing Manual fills the void. With its wealth of tips, instructions, and expert advice, this comprehensive resource is your ticket to making your time at the computer safer, easier, and more fun. And best of all, it's been updated to include detailed coverage of Service Pack 2. Written in easy-to-follow, jargon-free language, Windows XP Home Edition: The Missing Manual, Second Edition is perfectly suited for both first-time PC fans and budding power users. And like the rest of the Missing Manual series, it also relies on technical insight, crystal-clear objectivity, and a sense of humor--meaning no one will be left behind. The book begins with a tour of the Desktop and instructions for customizing the Taskbar and toolbars. It also includes a primer on how to organize files, folders, and windows for maximum efficiency. More advanced chapters explore control panels and built-in applications; walk through configurations like how to set up a PC for Internet use; and address the standard Windows rituals of troubleshooting, installation, and upgrading. For the height of manageability and control, the book also conveys all the need-to-know information about the security technologies featured in Windows XP SP2, so you can better defend yourself against viruses, worms, and hackers. Readers even receive guidelines and instructions for installing SP2 on their PC, or across a network of computers. Co-authored by David Pogue, New York Times computer columnist and Missing Manuals creator, this updated guide is the friendly, authoritative book that should have been in the box. It's sure to become your preferred guide whenever you sit down to Windows XP.
Bandwidth guaranteed multicast scheduling for virtual output queued packet switches (2005)

Multicast enables efficient data transmission from one source to multiple destinations, and has been playing an important role in Internet multimedia applications. Although several multicast scheduling schemes for packet switches have been proposed, they usually consider only short delay and high throughput but not bandwidth guarantees. However, fair bandwidth allocation is critical for the quality of service (QoS) of the network, and is necessary to support multicast applications requiring guaranteed performance services, such as online audio and video streaming. This paper addresses the issue of bandwidth guaranteed multicast scheduling on virtual output queued (VOQ) switches. We propose the credit based multicast fair scheduling (CMF) algorithm, which aims at achieving not only short multicast latency but also fair bandwidth allocation. CMF uses a credit/balance based strategy to guarantee the reserved bandwidth of an input port on each output port of the switch. It keeps track of the difference between the reserved bandwidth and actually received bandwidth, and minimizes the difference to ensure fairness. Moreover, CMF supports multicast scheduling by allowing a multicast packet to send transmission requests to multiple output ports simultaneously. As a result, a multicast packet has more chances to be delivered to all its destinations in the same time slot, and thus shortens its multicast latency. Extensive simulations are conducted to compare the performance of CMF with other existing scheduling algorithms, and the results demonstrate that CMF achieves the two design goals: short multicast latency and fair bandwidth allocation.
Efficient code management for dynamic multi-tiered compilation systems (2014)

Managed runtime environments (MREs) like web browsers or the Java Virtual Machine (JVM) include multiple dynamic compilers (or compiler configurations) to provide a good tradeoff between compilation speed and generated code quality: Longer compilation times typically imply better code quality and hence better peak performance than shorter compilation times, which provide good warmup/startup performance and lower peak performance. A system that uses multiple compilers is referred to as a multi-tiered compilation system.
Authenticated Quantum Secure Direct Communication with Qutrits (2008)

In this paper, a novel authenticated quantum secure direct communication scheme with three-dimension single photons is presented, where the message is encoded on batches of qutrits, and identity is mutual authenticated with their shared seed key. Security analysis shows that this scheme can efficiently resist Eve's attacks and the impersonator's attacks. Comparing with those protocols using entangled state, the presented scheme is more practical and economic within the present technology.
A Powerful Nonviral Vector for <i>In Vivo</i> Gene Transfer into the Adult Mammalian Brain: Polyethylenimine (1996)

Nonviral gene transfer into the central nervous system (CNS) offers the prospect of providing safe therapies for neurological disorders and manipulating gene expression for studying neuronal function. However, results reported so far have been disappointing. We show that the cationic polymer polyethylenimine (PEI) provides unprecedentedly high levels of transgene expression in the mature mouse brain. Three different preparations of PEI (25-, 50-, and 800-kD) were compared for their transfection efficiencies in the brains of adult mice. The highest levels of transfection were obtained with the 25-kD polymer. With this preparation, DNA/PEI complexes bearing mean ionic charge ratios closest to neutrality gave the best results. Under such conditions, and using a cytomegalovirus (CMV)-luciferase construction, we obtained up to 0.4 10(6) RLU/microgram DNA (equivalent to 0.4 ng of luciferase), which is close to the values obtained using PEI to transfect neuronal cultures and the more easily transfected newborn mouse brain (10(6) RLU/microgram DNA). Widespread expression (over 6 mm3) of marker (luciferase) or functional genes (bcl2) was obtained in neurons and glia after injection into the cerebral cortex, hippocampus, and hypothalamus. Transgene expression was found more than 3 months post-injection in cortical neurons. No morbidity was observed with any of the preparations used. Thus, PEI, a low-toxicity vector, appears to have potential for fundamental research and genetic therapy of the brain.
BindingDB Entry 50008194: Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[ (2021)

RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. Small-molecule inhibitors of RIP2 kinase or its signaling partners on the NOD2 pathway that are suitable for advancement into the clinic have yet to be described. Herein, we report our discovery and profile of the prodrug clinical compound, inhibitor <b>3</b>, currently in phase 1 clinical studies. Compound <b>3</b> potently binds to RIP2 kinase with good kinase specificity and has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human IBD explant samples. The highly favorable physicochemical and ADMET properties of <b>3</b> combined with high potency led to a predicted low oral dose in humans.
PRIMA-1MET induces death in soft-tissue sarcomas cell independent of p53 (2015)

PRIMA-1(MET) anti-tumor activity in STS partly results from off-target effects involving ROS toxicity and do not deserve further development as a TP53-targeted therapy in this setting.
Thermomechanical properties of polymeric materials and related stresses (1990)

The thermomechanical properties of a number of widely used polymeric materials were determined by thermomechanical analysis and dynamic mechanical analysis. A combined profile of the coefficient of thermal expansion and the modulus change over a wide temperature range obtained by the analyses shows clearly the drastic effect of the glass transition on both the CTE and the modulus of a polymer, and the damaging potential due to such effect.
A Tone Compression Model for the Compensation of White Point Shift Generated from HDR Rendering (2012)

Recently, a new image appearance model, named iCAM06, was developed for High-Dynamic-Range (HDR) image rendering. The dynamic range of a HDR image needs to be mapped onto the range of the output device where it will be displayed, this is called tone reproduction or tone mapping. iCAM06, a representative HDR rendering algorithm also uses tone compression for image reproduction on the dynamic range of output devices. However, iCAM06 causes a white point shift during its tone compression process. Therefore, we propose a compensation method for white point shifts using corrected channel gain. Experiment results show that the proposed method has better performance than iCAM06.
Orange Persistent Luminescence and Photodarkening Related to Paramagnetic Defects of Nondoped CaO-Ga<sub>2</sub>O<sub>3</sub>-GeO<sub>2</sub> Glass (2019)

Orange persistent luminescence and photodarkening phenomena were observed after ultraviolet (UV) excitation in calcium-gallium-germanate (CGG) glass with a composition of 3CaO-1Ga2O3-3GeO2 prepared by a melt-quenching method. The CGG glass was characterized by using X-ray diffraction, differential scanning calorimetry, and Raman scattering analyses. Also, the optical and electronic properties of the CGG glass were investigated. Based on the electron paramagnetic resonance (EPR) spectra, it is found that new defects, NBOHC (nonbridging oxygen hole center) and E’(Ge) (unpaired electron at Ge ion bonding three oxygen), were created after UV excitation. From the good agreement between the time dependence of the photodarkening absorption intensity and EPR intensity of the NBOHC, the origin of the photodarkening phenomenon is found to be caused by NBOHC. Also, from the relationship between the time dependence of persistent luminescence intensity and the time-derivative EPR intensities of NBOHC and E’(Ge) centers, the persistent luminescence is found to be caused by the recombination process between these two different defects.
Synthesis of molecular lines, rigid linear molecules with nanometer scale dimensions (1988)

P. W. Kenny and L. L. Miller, J. Chem. Soc., Chem. Commun., 1988, 84 DOI: 10.1039/C39880000084
<title>Full-field speckle techniques in blood microcirculation monitoring</title> (2001)

Statistical analysis of images of time-integrated dynamic speckle patterns is considered as the tool for diagnostics and imaging of in vivo tissue dynamics such as blood microcirculation in superficial layers of human tissues and organs. Basic approach for blood microcirculation monitoring using the contrast analysis of time-averaged speckle images is known as LASCA (Laser Speckle Contrast Analysis) technique. This paper presents the modified version of LASCA, which is based on application of the localized probe light source and the spatial filtration of analyzed speckle pattern in the object plane. Being compared with classical LASCA technique, this method has the certain disadvantage as the necessity of scanning procedure to provide the reconstruction of maps of blood microcirculation parameters, but it gives the additional possibilities for the analysis of depth distributions of these parameters. Theoretical background for the depth-resolved analysis of blood microcirculation parameters on the basis of the concept of effective optical paths distributions for multiple scattered probe light is considered.