gebhart/patrepeval huggingface dataset:
Estimation of Tumor Interstitial Fluid Pressure (TIFP) Noninvasively (2016)

Tumor interstitial fluid pressure (TIFP), is a physiological parameter with demonstrated predictive value for a tumor's aggressiveness, drug delivery, as well as response to treatments such as radiotherapy and chemotherapy. Despite its utility, measurement of TIFP has been limited by the need for invasive procedures. In this work, the theoretical basis for approaching the absolute value of TIFP and the experimental method for noninvasively measuring TIFP are presented. Given specific boundary and continuity conditions, we convert theoretical variables into measurable variables by applying MRI technology. The work shows that TIFP in the central region of the tumor can be estimated by an analysis of the variation of tissue fluid motion in the tumor rim and surrounding tissue. It is determined from three noninvasive measurable parameters: i) an estimate of the velocity of the tumor interstitial fluid at the tumor surface, which is maximal, ii) a measurement of the distance from the tumor surface to where the tumor exudates are absorbed (or normalized), and iii) an estimate of the hydraulic conductivity of the interstitium through which the tumor exudate travels. We experimentally show that the fluid flow within the tumor rim is not uniform, even for a round shaped tumor, and demonstrate the procedures for the noninvasive measurement of TIFP.
Electronically Temperature Compensated Silicon Bulk Acoustic Resonator Reference Oscillators (2007)

The paper describes the design and implementation of an electronically temperature compensated reference oscillator based on capacitive silicon micromechanical resonators. The design of a 5.5-MHz silicon bulk acoustic resonator has been optimized to offer high quality factor (> 100 000) while maintaining tunability in excess of 3000 ppm for fine-tuning and temperature compensation. Oscillations are sustained with a CMOS amplifier. When interfaced with the temperature compensating bias circuit, the oscillator exhibits a frequency drift of 39 ppm over 100degC as compared to an uncompensated frequency drift of 2830 ppm over the same range. The sustaining amplifier and compensation circuitry were fabricated in a 2P3M 0.6-mum CMOS process.
Objective image analysis of the meibomian gland area (2013)

The meibomian gland area was objectively evaluated using the developed software. This system could be useful for objectively evaluating the effect of treatment on meibomian gland dysfunction.
In Vivo Cleavability of a Disulfide-Based Chimeric Opioid Peptide in Rat Brain (1995)

Brain delivery of systemically administered neuropeptide drugs may be achieved by the synthesis of chimeric peptides, wherein the peptide is coupled to transport vectors via avidin-biotin technology. The present study focuses on factors that optimize the linkage of drugs to transport vectors. The vector is the OX26 monoclonal antibody to the transferrin receptor, and the model peptide used in these studies is [Lys7]dermorphin (K7DA). The K7DA is monobiotinylated at the epsilon-amino group of the Lys7 residue with either a cleavable linker, e.g., disulfide, using NHS-SS-biotin, or a noncleavable linker, e.g., amide, using NHS-XX-biotin. Disulfide cleavage of the biotinylated derivative yields the desbiotinylated peptide, which is thiolated. Structures of the K7DA analogues were confirmed by secondary ion mass spectrometry. The biotinylated peptides were coupled to a thiol-ether conjugate of the OX26 antibody and either neutral avidin (NLA) or streptavidin. The binding constants (Ki) of the K7DA, the biotinylated K7DA (bio-XX-K7DA), the desbiotinylated K7DA, and the bio-XX-KD7A conjugated to NLA-OX26 were 0.62 +/- 0.14, 1.59 +/- 0.27, 1.24 +/- 0.24, and > 10 nM, respectively, and were determined with a mu-opioid peptide radioreceptor assay. Comparable results were obtained with in vivo tail-flick analgesia testing following intracerebroventricular (icv) injection of opioid chimeric peptides. Reversibility of pharmacologic action of thiolated peptide was demonstrated by icv naloxone administration. The cleavability of the disulfide linker in vivo in rat plasma and brain was assessed with gel filtration HPLC and internal carotid artery perfusion of labeled opioid chimeric peptides.(ABSTRACT TRUNCATED AT 250 WORDS)
<title>Autostereoscopic display with high brightness and power efficiency</title> (1994)

Dimension Technologies Inc. has experimentally demonstrated an optical system that produces autostereoscopic images and also allows very high brightness and power efficiency to be achieved using off the shelf color LCDs. This capability is important in applications such as cockpit displays or mobile, portable, or laptop systems where brightness must be maximized but power conserved as much as possible. The effects are achieved through the creation of light line illumination, by means of which autostereoscopic images are produced, and by simultaneously concentrating the light emitted by the display toward the area the viewer's head is. By turning different illumination sources on and off, it is possible to aim both the concentration area and the 3D viewing area at the observer's head as the observer moves. A variation on the system allows two or more persons to be tracked independently. Cross talk (ghosting) can be reduced to the point that imperceptibility can be achieved.
A high-capacity wireless network by quad-sector cell and interleaved channel assignment (2000)

We propose an improved sectorization scheme, called narrow-beam quad-sector cell (NBQC) for cellular networks, in which each cell is divided into four sectors and each sector is covered by a 60/spl deg/ antenna. The NBQC structure allows easy implementation of the concept of interleaved channel assignment (ICA), which can take full advantage of antenna directivity. With ICA, the NBQC system can enhance the system performance from several perspectives. First, the NBQC has better coverage performance than the current three-sector cellular architecture. Second, we demonstrate that in a typical radio environment, the NBQC system ran achieve a reuse cluster size N=2 with the signal-to-interference ratio (SIR) as high as 11 dB in 90% of the cell area, which is a 3-5-dB improvement over the existing cellular architectures. Third, as compared to the most advanced three-sector clover-leaf cell architecture with reuse cluster size N=3, the NBQC system with ICA can achieve reuse cluster size N=2 with very slight degradation in SIR performance, thereby still improving the system capacity by about 10% over a wide range of ninetieth percentile SIR requirements.
Sequence of a cDNA for mouse thrombomodulin and comparison of the predicted mouse and human amino acid sequences (1989)

Thrombomodulin is an endothelial cell surface anticoagulant cofactor for activation of the serum protease protein C. We have previously described a complete cDNA for human
HIV-1 coreceptor usage and CXCR4-specific viral load predict clinical disease progression during combination antiretroviral therapy (2008)

HIV-1 coreceptor usage and X4-specific viral loads strongly predicted disease progression during cART, independent of and in addition to CD4 cell count or total viral load. Detection and quantification of X4 strains promise to be clinically useful biomarkers to guide patient management and study HIV-1 pathogenesis.
Time synchronization over ethernet passive optical networks (2012)

Time synchronization is critical when using Ethernet passive optical networks as a mobile backhaul to support time-sensitive services. This article presents an overview of time synchronization methods over EPON. It outlines the requirements and challenges particular to the EPON link delay asymmetry, and presents the technical solution recently approved by IEEE. Performance analysis and prototype results demonstrate that this technical solution meets various time synchronization requirements. The article then reviews the major standard efforts on EPON time synchronization that employ this solution, IEEE Std 802.1AS <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> -2011 Clause 13. With this standard in place, EPON can play its part in time distribution networks.
APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer (2015)

Serum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.
Static and Dynamic Calibration of Phasor Measurement Units (2019)

The testing and calibration of phasor measurement units (PMUs) are key points for whether they will be effective in the power system. Therefore, providing valid test reference values with enough precision under both steady-state and dynamic conditions plays a crucial role. In this paper, based on the description of a PMU testing system including a PMU calibrator, general signal models for PMU static and dynamic tests are outlined. A phasor measurement algorithm suitable for the PMU calibrator based on a non-linear fitting method is proposed. In addition, the setting methods of the initial points and bound constraints of the parameters to be fitted are proposed to ensure the solution uniqueness of the non-linear fitting method. The effect of hardware system random uncertainty on measurement accuracy is analyzed, and the corresponding solutions are proposed to improve measurement accuracy. Then, high performance hardware is selected to build a PMU calibrator. To verify the measurement accuracy of the built PMU calibrator, experimental tests under static and dynamic conditions are carried out. The results show that the accuracy of the PMU calibrator can meet the calibration requirements and the built PMU calibrator can be used to test PMU in the laboratory.
Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination (2015)

Molecular trafficking within cells, tissues and engineered three-dimensional multicellular models is critical to the understanding of the development and treatment of various diseases including cancer. However, current tracking methods are either confined to two dimensions or limited to an interrogation depth of ∼15 μm. Here we present a three-dimensional tracking method capable of quantifying rapid molecular transport dynamics in highly scattering environments at depths up to 200 μm. The system has a response time of 1 ms with a temporal resolution down to 50 μs in high signal-to-noise conditions, and a spatial localization precision as good as 35 nm. Built on spatiotemporally multiplexed two-photon excitation, this approach requires only one detector for three-dimensional particle tracking and allows for two-photon, multicolour imaging. Here we demonstrate three-dimensional tracking of epidermal growth factor receptor complexes at a depth of ∼100 μm in tumour spheroids.
Discovery of a Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitor for the Potential Treatment of Schizophrenia (2014)

We report the discovery of a series of imidazo[1,2-a]pyrazine derivatives as novel inhibitors of phosphodiesterase 10A (PDE10A). In a high-throughput screening campaign we identified the imidazopyrazine derivative 1, a PDE10A inhibitor with limited selectivity versus the other phosphodiesterases (PDEs). Subsequent investigation of 1 and replacement of the trimethoxyphenyl group by a (methoxyethyl)pyrazole moiety maintained PDE10A inhibition but enhanced selectivity against the other PDEs. Systematic examination and analysis of structure-activity and structure-property relationships resulted in the discovery of 2, an in vitro potent and selective inhibitor of PDE10A with high striatal occupancy of PDE10A, promising in vivo efficacy in different rodent behavioral models of schizophrenia, and a good pharmacokinetic profile in rats.
Deeply-supervised CNN for prostate segmentation (2017)

Prostate segmentation from Magnetic Resonance (MR) images plays an important role in image guided intervention. However, the lack of clear boundary specifically at the apex and base, and huge variation of shape and texture between the images from different patients make the task very challenging. To overcome these problems, in this paper, we propose a deeply supervised convolutional neural network (CNN) utilizing the convolutional information to accurately segment the prostate from MR images. The proposed model can effectively detect the prostate region with additional deeply supervised layers compared with other approaches. Since some information will be abandoned after convolution, it is necessary to pass the features extracted from early stages to later stages. The experimental results show that significant segmentation accuracy improvement has been achieved by our proposed method compared to other reported approaches.
UP-REGULATION OF BONE MORPHOGENETIC PROTEINS IN CULTURED MURINE BONE CELLS WITH USE OF SPECIFIC ELECTRIC FIELDS (2006)

Background: Capacitively coupled electric stimulation has been successfully used in the treatment of bone nonunions and to effect spinal fusions. However, the pathway of biologic events whereby this is accomplished has not been fully elucidated. To determine whether bone morphogenetic proteins (BMPs) could be involved, the effect of electrical stimulation on BMP gene expression was investigated. Methods: Postconfluent cultures of MC3T3-E1 bone cells were exposed to a series of capacitively coupled signals in which the duration, amplitude, frequency, and duty cycle were sequentially and systematically varied. The cellular response was measured by quantifying the mRNA levels of BMP-2 through BMP-8, as well as the BMP antagonists gremlin and noggin, with use of reverse transcription followed by real-time quantitative polymerase chain reaction. BMP-2 protein was measured by enzyme-linked immunosorbent assay, and alkaline phosphatase activity was measured by a specific colorimetric assay. Results: The results showed that BMP-2 through BMP-8, gremlin, and noggin were all normally expressed by MC3T3-E1 cells, and could be significantly up-regulated by specific and selective capacitively coupled electric fields (p < 0.05). However, mRNA expression for BMP-2, 4, 5, 6, and 7 was consistently up-regulated several times higher than that for BMP-3 and BMP-8, gremlin, and noggin under identical conditions. Concomitantly, BMP-2 protein production and alkaline phosphatase activity were both significantly increased in the same electrically stimulated cultures (p = 0.001 and p < 0.01, respectively). Conclusions: These data clearly show that our optimal capacitively coupled signal (60 kHz, 20 mV/cm at a 50% duty cycle for twenty-four hours) can specifically, selectively, and simultaneously up-regulate the expression of a number of osteoinductive BMPs; other BMPs and antagonists are only moderately affected. Clinical Relevance: Electrical stimulation may be a useful treatment modality for in vivo situations where bone induction is required, since it is noninvasive, safe, effective, can be easily targeted to a variety of anatomic sites, can provide a controlled production of BMPs, and can be used repeatedly. The optimal duration (continuous stimulation at 100% duty cycle) and frequency (60 kHz) determined in this in vitro study are the same—and the amplitude (20 mV/cm) is in the same range (12 mV/cm)—as are used clinically.
Hinged substrate for large-aperture lightweight deformable mirrors: a novel concept (2002)

A novel concept for large aperture lightweight deformable mirrors is presented. This new concept is based on using a flexure-hinged truss substrate as opposed to monolithic substrates used in all past and current deformable mirror technologies. With its ability to deform in tangential as well as normal directions, this new concept solves the problem of coefficient of thermal expansion (CTE) mismatch between face sheet and substrate. It takes advantage of the newly emerging face sheet technologies such as nanolaminates that produce extremely lightweight optical quality face sheets and require very small forces to deform them. It also provides rigidity to the thin face sheet mirror, necessary for the uniqueness of response to actuator commands and for tolerance to disturbances. Any stresses in substrate structure are mainly limited to those induced by the forces in the face sheet itself, which are small in the new lightweight face sheets. The dynamic range of deformation is limited only by the actuator stroke, and not by the stresses induced in the substrate. Therefore it drives the actuator design to small force large stroke actuators, as opposed to the current designs that use large force small stroke moment actuators.
<i>N</i><sup>6</sup>,5‘-Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A<sub>3</sub> Receptor (1999)

5'-(Alkylthio)-substituted analogues of N6-benzyl- and N6-(3-iodobenzyl)adenosine were synthesized in 37-61% overall yields. The affinities of these compounds for the adenosine A1, A2A, and A3 receptors were determined using rat brain cortex, rat brain striata, and stably transfected human A3 receptors in HEK 293 cells, respectively. The compounds proved to be selective for the adenosine A3 receptor and displayed affinities in the nanomolar range. Compounds 8, 10, and 11 had the highest affinities for the A3 receptor with Ki values ranging from 8.8 to 27.7 nM. In the N6-benzyl series, compound 4 (LUF 5403), with a 5'-methylthio group, maintained a reasonable affinity and had the highest selectivity for the A3 receptor. Compound 12 (LUF 5411), with an N6-(3-iodobenzyl) group and a 5'-(n-propylthio) substituent, had the highest A3 selectivity of all of the compounds and also displayed high affinity for this receptor (Ki = 44.3 nM). The compounds were also evaluated for their ability to stimulate [35S]GTPgamma[S] binding in cell membranes expressing the human adenosine A3 receptor. It appeared that the N6,5'-disubstituted adenosine derivatives behaved as partial agonists. Compounds 2, 4, 8, and 10 had the highest intrinsic activities. Additionally, when tested in a cAMP assay, these compounds also behaved as partial agonists.
Ultrafast digital holography for in vivo retinal blood flow imaging and assessment of flow resistance (2019)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text L. Puyo, M. Paques, M. Fink, J. Sahel, and M. Atlan, "Ultrafast digital holography for in vivo retinal blood flow imaging and assessment of flow resistance," in Digital Holography and Three-Dimensional Imaging 2019, OSA Technical Digest (Optica Publishing Group, 2019), paper Th1A.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
R176502, a New Bafilolide Metabolite with Potent Antiproliferative Activity from a Novel Micromonospora Species (2003)

During the course of a screening program intended to identify new antiproliferative agents, a new bafilolide metabolite was discovered. R176502 (1) was isolated from the liquid fermentation cultures of a novel Micromonospora species found in African river bottom sediment. It was purified from ethyl acetate extracts using a series of countercurrent chromatographic steps. The structure was determined using 1- and 2-D NMR experiments. Three previously described bafilomycins (bafilomycins A1 (2), B1 (3), and B2 (4)) were also isolated (from other microbial strains). R176502 exhibited potency for inhibition of tumor cell proliferation in the nM range of concentrations.
Experience Individualization on Online TV Platforms through Persona-based Account Decomposition (2016)

Online TV has seen rapid growth in recent years, with most of the large media companies broadcasting their linear content online. Access to the online TV accounts is protected by an authentication, and like the traditional cable TV subscription, users in the same household share the online TV credentials. However, as the standard data collection techniques have capability to collect only account level information, online TV measurements fail to capture individual level viewing characteristics in shared accounts. Thus, individual profile identification and experience individualization are challenging and difficult for online TV platforms. In this paper, we propose a novel approach to decompose online TV account into distinct personas sharing the account through analyzing viewing characteristics. A recommendation algorithm is then proposed to individualize the experience for each persona. Finally, we demonstrate the usefulness of the proposed approach through experiments on a large online TV database.
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis (2017)

Asparagine endopeptidase (AEP), also called legumain, is highly expressed in various solid tumors, promoting cancer cell invasion, migration, and metastasis. It has been proposed to be a prognostic marker and therapeutic target for cancer treatment. However, an effective nonpeptide, small-molecule inhibitor against this protease has not yet been identified. Here we show that a family of xanthine derivatives selectively inhibit AEP and suppress matrix metalloproteinase (MMP) cleavage, leading to the inhibition of cancer metastasis. Through structure-activity relationship (SAR) analysis, we obtained an optimized lead compound (38u) that represses breast cancer invasion and migration. Chronic treatment of nude mice, which had been inoculated with MDA-MB-231 cells, with inhibitor 38u via oral administration robustly inhibits breast cancer lung metastasis in a dose-dependent manner, associated with blockade of MMP-2 by AEP. Therefore, our study supports that 38u might act as a potent and specific AEP inhibitor useful for cancer treatment.
Integrated Electromechanical Double-Rotor Compound Hybrid Transmissions for Hybrid Electric Vehicles (2015)

Integrated hybrid transmissions serve as the key component in hybrid electric vehicles (HEVs). This paper reviews several technologies of the electromechanical integration of advanced hybrid transmission systems. Detailed configurations, fundamentals of operating principles, and various operating modes were comprehensively explained and analyzed. Combining the merits, an integrated electromechanical double-rotor compound hybrid transmission that is potentially more compact and has better performance is proposed. Detailed operation modes are compared, and functions and cooperation between integrated components are illustrated. As the core component of the integrated transmission, the double-rotor electric machine is studied via drive-cycle analyses, and a scaled-down prototype is built according to the drive-cycle analysis results. Test results successfully validate the design and simulation process.