gebhart/patrepeval huggingface dataset:
Why Integrin as a Primary Target for Imaging and Therapy (2011)

Integrin-mediated cell adhesion is involved in many essential normal cellular and pathological functions including cell survival, growth, differentiation, migration, inflammatory responses, platelet aggregation, tissue repair and tumor invasion. 24 different heterodimerized transmembrane integrin receptors are combined from 18 different α and 8 different β subunits. Each integrin subunit contains a large extracellular domain, a single transmembrane domain and a usually short cytoplasmic domain. Integrins bind extracellular matrix (ECM) proteins through their large extracellular domain, and engage the cytoskeleton via their short cytoplasmic tails. These integrin-mediated linkages on either side of the plasma membrane are dynamically linked. Thus, integrins communicate over the plasma membrane in both directions, i.e., outside-in and inside-out signaling. In outside-in signaling through integrins, conformational changes of integrin induced by ligand binding on the extracellular domain altered the cytoplasmic domain structures to elicit various intracellular signaling pathways. Inside-out signaling originates from non-integrin cell surface receptors or cytoplasmic molecules and it activates signaling pathways inside the cells, ultimately resulting in the activation/deactivation of integrins. Integrins are one of key family proteins for cell adhesion regulation through binding to a large number of ECM molecules and cell membrane proteins. Lack of expression of integrins may result in a wide variety of effects ranging from blockage in pre-implantation to embryonic or perinatal lethality and developmental defects. Based on both the key role they played in angiogenesis, leukocytes function and tumor development and easy accessibility as cell surface receptors interacting with extracellular ligands, the integrin superfamily represents the best opportunity of targeting both antibodies and small-molecule antagonists for both therapeutic and diagnostic utility in various key diseases so far.
Novel syntheses of hydantoin derivatives<i>K</i> (1978)

Abstract N ‐Substituted hydantoin derivatives have been synthesized by the condensation of an α‐amino acid derivative, a primary amine and diphenyl carbonate. The method has been applied to the synthesis of hydantoin derivatives with two hydroxyl and/or carboxyl groups.
On Model Discovery For Hosted Data Science Projects (2017)

Alongside developing systems for scalable machine learning and collaborative data science activities, there is an increasing trend toward publicly shared data science projects, hosted in general or dedicated hosting services, such as GitHub and DataHub. The artifacts of the hosted projects are rich and include not only text files, but also versioned datasets, trained models, project documents, etc. Under the fast pace and expectation of data science activities, model discovery, i.e., finding relevant data science projects to reuse, is an important task in the context of data management for end-to-end machine learning. In this paper, we study the task and present the ongoing work on ModelHub Discovery, a system for finding relevant models in hosted data science projects. Instead of prescribing a structured data model for data science projects, we take an information retrieval approach by decomposing the discovery task into three major steps: project query and matching, model comparison and ranking, and processing and building ensembles with returned models. We describe the motivation and desiderata, propose techniques, and present opportunities and challenges for model discovery for hosted data science projects.
Oberflächenanalytische Charakterisierung von metallischen Verunreinigungen und Oxiden auf GaAs (1997)

Oberfliichenanalytische Charakterisierung von metallischen Verunreinigungen und Oxiden auf GaAs
Porcine skin as an in-vivo model for ageing of human bite marks. (2005)

Porcine skin has been shown to have similar histological, physiological and immunological properties to human skin and has been suggested as a good analogue for medical and forensic research. This study was undertaken to examine the appearance of bite mark wounds inflicted at known time intervals before and after death. Under general anaesthesia, a series of bite marks were created on a pig's abdomen with a device designed to mechanically produce simulated human bite mark wounds. The pig skin model showed that bite mark characteristics are similar to those found on human skin. This study has provided information on the window of time showing clearly detailed bite marks occurring around the time of death. It also demonstrated that it is possible under certain conditions to determine that a bite mark was made before or after death in a porcine model. Under these experimental conditions, the results suggest that an in-vivo porcine skin model should be considered as a representative model for the study of human bite marks.
Characterizing Floral Symmetry in the Core Goodeniaceae with Geometric Morphometrics (2016)

Core Goodeniaceae is a clade of ~330 species primarily distributed in Australia. Considerable variation in flower morphology exists within this group and we aim to use geometric morphometrics to characterize this variation across the two major subclades: Scaevola sensu lato (s.l.) and Goodenia s.l., the latter of which was hypothesized to exhibit greater variability in floral symmetry form. We test the hypothesis that floral morphological variation can be adequately characterized by our morphometric approach, and that discrete groups of floral symmetry morphologies exist, which broadly correlate with subjectively determined groups. From 335 images of 44 species in the Core Goodeniaceae, two principal components were computed that describe >98% of variation in all datasets. Increasing values of PC1 ventralize the dorsal petals (increasing the angle between them), whereas increasing values of PC2 primarily ventralize the lateral petals (decreasing the angle between them). Manipulation of these two morphological "axes" alone was sufficient to recreate any of the general floral symmetry patterns in the Core Goodeniaceae. Goodenia s.l. exhibits greater variance than Scaevola s.l. in PC1 and PC2, and has a significantly lower mean value for PC1. Clustering clearly separates fan-flowers (with dorsal petals at least 120° separated) from the others, whereas the distinction between pseudo-radial and bilabiate clusters is less clear and may form a continuum rather than two distinct groups. Transitioning from the average fan-flower to the average non-fan-flower is described almost exclusively by PC1, whereas PC2 partially describes the transition between bilabiate and pseudo-radial morphologies. Our geometric morphometric method accurately models Core Goodeniaceae floral symmetry diversity.
Wireless Sensor Networks for domestic energy management in smart grids (2010)

Wireless Sensor Networks (WSN) are getting more integrated to our daily lives and smart surroundings as they are being used for health, comfort and safety applications. In smart homes and office environments, WSNs are generally used to increase the inhabitant comfort. As the current energy grid is evolving into a smart grid, where consumers can directly reach and control their consumption, WSNs can take part in domestic energy management systems, as well. In this paper, we propose the Appliance Coordination (ACORD) scheme, that uses the in-home WSN and reduces the cost of energy consumption. The cost of energy increases at peak hours, hence reducing the peak demand is a major concern for utility companies. The ACORD scheme, aims to shift consumer demands to off-peak hours. Appliances use the readily available in-home WSN to deliver consumer requests to the Energy Management Unit (EMU). EMU schedules consumer requests with the goal of reducing the energy bill. We show that ACORD decreases the cost of electricity usage of home appliances significantly.
Alternative Pharmacological Interventions that Limit Myocardial Infarction (2008)

Despite current optimal treatment, the morbidity and mortality of coronary heart disease remain significant worldwide and open the way for the development of novel cardioprotective therapies. In the last two decades, a remarkable scientific effort has focused on the limitation of infarct size. Important input from experimental studies has led the way in this direction. However, clinical and preclinical results using various cardioprotective strategies to attenuate reperfusion injury have generally not been applicable for every day clinical practice. Protection of the ischemic myocardium is known to occur as a result of ischemic preconditioning (PC), in which repetitive brief periods of ischemia protect the heart from a subsequent prolong ischemic insult. Although PC is a powerful form of protection, it is of limited clinical application for obvious ethical and practical reasons. Another endogenous form of cardioprotection, similar to PC but applicable at the time of reperfusion, termed postconditioning (PostC), has been recently described. Short series of repetitive cycles of brief reperfusion and re-occlusion of the coronary artery applied at the onset of reperfusion, reduce the infarct size and coronary artery endothelial dysfunction. At present, pharmacological PC and PostC are possible alternative methods that may substitute pharmaceutical treatments the short ischemic insults. Adenosine, nicorandil and other agents have been already used as pharmacological mimetics of ischemic PC in multicenter trials. We summarize the recent research efforts on novel therapeutic strategies and on the design of new compounds, based on the accumulated knowledge of the ligands, receptors and intracellular signaling pathways of PC and PostC.
Facial Expression Recognition Based on Edge Detection (2015)

Relational Over the last two decades, the advances in computer vision and pattern recognition power have opened the door to new opportunity of automatic facial expression recognition system This paper use Canny edge detection method for facial expression recognition. Image color space transformation in the first place and then to identify and locate human face .Next pick up the edge of eyes and mouth's features extraction. Last we judge the facial expressions after compared with the expressions we known in the database. This proposed approach provides full automatic solution of human expressions as well as overcoming facial expressions variation and intensity problems.
Reformer: The Efficient Transformer (2020)

Large Transformer models routinely achieve state-of-the-art results on a number of tasks but training these models can be prohibitively costly, especially on long sequences. We introduce two techniques to improve the efficiency of Transformers. For one, we replace dot-product attention by one that uses locality-sensitive hashing, changing its complexity from O($L^2$) to O($L\log L$), where $L$ is the length of the sequence. Furthermore, we use reversible residual layers instead of the standard residuals, which allows storing activations only once in the training process instead of $N$ times, where $N$ is the number of layers. The resulting model, the Reformer, performs on par with Transformer models while being much more memory-efficient and much faster on long sequences.
Thermal stress and reliability characterization of barriers for Cu interconnects (2001)

MOCVD TiSiN was evaluated as a barrier for Cu interconnects application. The TiSiN film was formed by SiH/sub 4/ soaking of MOCVD TiN. The TiSiN film showed improved wetting and adhesion to Cu as well as less stress hysteresis in its integration with Cu. The low stress hysteresis yields higher resistance to Cu void generation during hot storage testing. Electrical tests on DLM Cu test structures demonstrated comparable line and via chain resistance and equivalent line-to-line leakage current in BTS testing compared to conventional PVD Ta(N).
Lewis Acids as Highly Efficient Catalysts for the Decarboxylative Esterification of Carboxylic Acids with Dialkyl Dicarbonates. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Magnetic vector field tag and seal (2023)

One or more magnets are placed in a container (preferably on objects inside the container) and the magnetic field strength and vector direction are measured with a magnetometer from at least one location near the container to provide the container with a magnetic vector field tag and seal. The location(s) of the magnetometer relative to the container are also noted. If the position of any magnet inside the container changes, then the measured vector fields at the these locations also change, indicating that the tag has been removed, the seal has broken, and therefore that the container and objects inside may have been tampered with. A hollow wheel with magnets inside may also provide a similar magnetic vector field tag and seal. As the wheel turns, the magnets tumble randomly inside, removing the tag and breaking the seal.
Ordering the Reductive and Cytochrome P450 Oxidative Steps in Demethylsterigmatocystin Formation Yields General Insights into the Biosynthesis of Aflatoxin and Related Fungal Metabolites (2005)

The biosynthesis of the potent environmental carcinogen aflatoxin B1 involves ca. 15 steps beyond the first polyketide intermediate. Central among these is the rearrangement of the anthraqinone versicolorin A to the xanthone demethylsterigmatocystin. Genetic evidence strongly suggests that two enzymes are required for this process, a cytochrome P450, AflN, and a probable NADPH-dependent oxidoreductase, AflM. Given the overall redox change evident in this skeletal rearrangement, two rounds of oxidation and a reduction necessarily occur. Earlier experiments indicated that reductive deoxygenation of versicolorin A is not the first step. In the present report we consider a mechanistic alternative that AflM-mediated reduction is instead the last of these three reactions prior to formation of the xanthone intermediate. To this end, 9-hydroxydihydrodemethylsterigmatocystin was prepared by total synthesis as was its 9-deoxy analogue, an established aflatoxin precursor. During the final isolation of the "angular" synthetic xanthone targets it was found that acid catalysis promoted their isomerization to thermodynamically favored "linear" xanthones. Whole-cell and ground-cell incubations of the 9-hydroxy- and 9-deoxyxanthones were conducted with a mutant strain of Aspergillus parasiticus blocked at the first step of the pathway and examined for their ability to support aflatoxin production. The 9-deoxyxanthone gave dramatically enhanced levels of the mycotoxin. The 9-hydroxyxanthone, on the other hand, afforded no detectable increase in aflatoxins above controls, indicating that reductive deoxygenation at C-9 of a xanthone precursor does not take place in aflatoxin biosynthesis. Constraints imposed by earlier studies and the experiments in this paper serve to eliminate simple and intuitive conversions of versicolorin A to demethylsterigmatocystin and lead inescapably to a more subtle reaction sequence of oxidation-reduction-oxidation. Previous puzzling observations of extensive A-ring hydrogen exchange in the course of the rearrangement of versicolorin A to demethylsterigmatocystin have now been explained by a new mechanism that is consistent with all extant data. We propose that P450-mediated aryl epoxidation (AflN) initially disrupts the aromatic A-ring of versicolorin A. Oxirane opening enables A-ring proton exchange, as does the subsequent AflM-mediated reductive step. A second cycle of P450 oxidation (AflN), this time a Baeyer-Villiger cleavage, enables decarboxylation and the formation of demethylsterigmatocystin. Mechanistic and stereoelectronic principles that underlie this proposal are described and may prove general as illustrated in biogenetic hypotheses for four other fungal anthraquinone --> xanthone transformations.
CINETOON: A Semi-automated System for Rendering Black/White Comic Books from Video Streams (2008)

In this paper we propose CINETOON, a semi-automated system which can generate black/white comic books from a sequence of video streams obtained from cinemas. CINETOON provides an intuitive interface to render comics. Our system consists of four major components : Key Frame Extractor, Image-based Comic Cut Converter, Background Effect Stylizer and Comic Elements Renderer. First, to capture the frame image from the video stream, we generate a workspace file which includes the frame images and script files. Second, the comic converter is decoupled into two processes: image binarization and stroke extraction. We introduce one novel black/white binarization algorithm for the frame images. Third, in order to segment foreground object, we propose a simple and straightforward algorithm implemented in the background effect stylizer. Also CINETOON provides some classes of shape-controllable icons such as word balloon, stylized fonts, speed line and specialized icons. The comic pages produced by our system show that CINETOON was so successful to make a comic book from a well-known cinema in a reasonable time and manual intervention.
Dimethylethylamine alane and N-methylpyrrolidine alane. A convenient synthesis of alane, a useful selective reducing agent in organic synthesis (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDimethylethylamine alane and N-methylpyrrolidine alane. A convenient synthesis of alane, a useful selective reducing agent in organic synthesisEverett M. Marlett and Won Suh ParkCite this: J. Org. Chem. 1990, 55, 9, 2968–2969Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://doi.org/10.1021/jo00296a078RIGHTS & PERMISSIONSArticle Views1476Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (318 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Towards immunotherapy for peanut allergy (2005)

Food allergy affects approximately 4-6% of children and 3-4% of adults. Peanut allergy can be devastating as reactions range from urticaria to severe anaphylactic shock and death. The only preventive measure for peanut allergy is strict avoidance of the incriminating food. It is likely immunotherapy will be available in the near future as a well tolerated and effective therapy for treating peanut allergy. The use of the anti-IgE therapy in conjunction with other immunotherapy would possibly be the best treatment option in the future.
Design of active phase shifters based on multichannel heterojunction field effect transistors (MCHFET's) (1996)

Design criteria of active phase shifters based on GaAs/AlGaAs multichannel (MC) HFET in the frequency range 4-60 GHz are presented. The phase characteristics of MCHFET devices were studied using the computer aided design program TOUCHSTONE. The dependence of transmission phase on various intrinsic elements in the equivalent circuit model as a function of control gate bias was also studied. There are limited gate bias ranges which correspond to the active regions of the two conducting wells for which a quasi-linear continuous phase shift for analog applications was achieved. Continuously varying the gate bias from V/sub gs/=-1.9 V to V/sub gs/=-0.6 V results in a quasilinear phase shift of 10/spl deg/, 15/spl deg/, 21/spl deg/, and 29/spl deg/ at f=12, 20, 30, and 60 GHz, respectively. Similarly, varying the gate bias from V/sub gs/=-0.4 V to V/sub gs/=0.7 V a quasi-linear phase shift of 21/spl deg/, 26/spl deg/, 27/spl deg/, and 23/spl deg/ at f=12, 20, 30, and 60 GHz, respectively, was achieved. The gain variation was less than 3 dB in these bias regions. With digital applications in mind, a maximum differential phase shift of around 50/spl deg/ was obtained by switching the gate bias discretely. The transmission phase of single gate MCHFET mostly depends on variation of gate source capacitance with gate bias rather than on other intrinsic elements. The dependence of phase shift on various geometrical and structural parameters is also presented. To test the practicality of the device, other scattering parameters (e.g., S/sub 11/, S/sub 22/, S/sub 12/) and the noise figure (NF) were finally studied.
Comparing gaze-based and manual interaction in a fast-paced gaming task in Virtual Reality (2011)

Neither individual expression of CD24 or CD44, nor combined expression of CD44/CD24 was associated with recurrence of gastric carcinoma.
Fractional frequency reuse for irregular geometry based heterogeneous cellular networks (2015)

Indoor coverage and capacity are the major limitations of the current cellular systems. In such perspective, femtocells deployment has attracted considerable interest. However, the random and co-channel deployment of femtocells poses severe interference management challenges, especially at the cell edges. Recently, Fractional Frequency Reuse (FFR) has emerged an attractive technique for co-tier and cross-tier interference in multi-tier cellular deployment. However, most of the previous work analyzes the performance of FFR for perfect cell geometry models. Applying regular resource of the standard FFR scheme to the realistic cellular networks with high irregularity in the cell geometry and channel conditions leads to sub-optimal performance. In this paper we investigate the performance of FFR for two-tier cellular network based on irregular cell geometry. To capture the realistic network scenario the position of Macro Base Stations (MBSs) and Femto Base Station (FBSs) are modeled with Hard Core Point Process (HCPP) and Poisson Point Process (PPP) respectively. Furthermore, Sectored-FFR scheme with optimal sub-band allocation is proposed in this paper and the capacity of the system is evaluated. Simulation results show that the proposed Sectored-FFR scheme outperforms the conventional FFR schemes in terms of throughput and capacity.