gebhart/patrepeval huggingface dataset:
[Differential expression of the anti-oncogene ARHI between patients with and without endometriosis]. (2011)

ARHI expressions are present in the endometrium and up-regulated in ectopic endometrium, whereas in the ectopic endometrium of patients with malignant endometriosis its expression is often negative, suggesting a role of ARHI in infertility and tumorigenesis of endometriosis.
Dynamic Path Planning for Inserting a Steerable Needle Into a Soft Tissue (2013)

Steerable bevel-tip needles are widely used in modern, minimally invasive percutaneous procedures to reach specific areas inside the body. In this paper, we propose an optimized path planner for manipulating such steerable needles, which can generate the shortest path from the starting position to the target position with the least number of rotation times. The shortest traveling path produces less damage to the body, thus shortening the recovery period. We first investigate the insertion problem in a nondeformable environment, which is termed as the static environment in this paper. As the needle is flexible, the moving path is a curve. We propose to regulate the curved path within two parallel lines and then determine the optimal distance between the two parallel lines such that the generated moving path of the needle has the shortest length with the least number of needle rotations. We then investigate the insertion problem in a deformable environment, which is termed as the dynamic environment. Taking deformation and nonhomogenous properties of soft tissue into account, the target position and the radius of the curve path vary as the needle is inserted. By using a mass-spring model to formulate the deformable environment and a vision system to measure the time-varying radius of the curve, we propose a dynamic path planner that replans the path to adapt to the change of the target position and the curve radius. Simulations and experiments are performed to demonstrate the effectiveness of the proposed approach.
Moxidectin and ivermectin inhibit SARS-CoV-2 replication in Vero E6 cells but not in human primary airway epithelium cells (2021)

Abstract Antiviral therapies are urgently needed to treat and limit the development of severe COVID-19 disease. Ivermectin, a broad-spectrum anti-parasitic agent, has been shown to have anti-SARS-CoV-2 activity in Vero cells at a concentration of 5 µM. These in vitro results triggered the investigation of ivermectin as a treatment option to alleviate COVID-19 disease. In April 2021, the World Health Organization stated, however, the following: “the current evidence on the use of ivermectin to treat COVID-19 patients is inconclusive”. It is speculated that the in vivo concentration of ivermectin is too low to exert a strong antiviral effect. Here, we performed a head-to head comparison of the antiviral activity of ivermectin and a structurally related, but metabolically more stable, moxidectin in multiple in vitro models of SARS-CoV-2 infection, including physiologically relevant human respiratory epithelial cells. Both moxidectin and ivermectin exhibited antiviral activity in Vero E6 cells. Subsequent experiments revealed that the compounds predominantly act on a step after virus cell entry. Surprisingly, however, in human airway-derived cell models, moxidectin and ivermectin failed to inhibit SARS-CoV-2 infection, even at a concentration of 10 µM. These disappointing results calls for a word of caution in the interpretation of anti-SARS-CoV-2 activity of drugs solely based on Vero cells. Altogether, these findings suggest that, even by using a high-dose regimen of ivermectin or switching to another drug in the same class are unlikely to be useful for treatment against SARS-CoV-2 in humans.
Stacking sequence blending of multiple composite laminates using genetic algorithms (2001)

Abstract This paper presents a methodology for designing any two-dimensional array of laminated composite panels with varying loads such that continuity of some or all of the plies is maintained across adjacent panels. This design process is commonly referred to as blending and is beneficial in helping to minimize the manufacturing effort and cost of the panels while meeting structural requirements at minimum weight. The methodology discussed here involves an automated 2-step optimization process using a commercial genetic algorithm software code called DARWIN . The methodology is tested using a 3×3 array of sandwich panels, and an 18-panel group arranged in a horseshoe pattern. Results for each design problem are generated using ADOPTECH's Java-based composite laminate design software called OLGA , which utilizes the DARWIN optimization engine. A comparison between the individually optimized panels designs and the blended designs for each design problem is also presented.
Properties of bulk polycrystalline CVD diamond (1993)

Considerable progress has been made in recent years on the synthesis of diamond by chemical vapour deposition (CVD) leading to substantial improvements in material quality and rate of synthesis. As a result it has been possible to manufacture relatively thick plates of free-standing bulk polycrystalline CVD diamond removing many of the limitations of thin-film coatings. This exploit has promoted CVD diamond from experimental novelty to a true engineering material opening a wide range of applications in which the unique properties of diamond can be used. This paper reports on a range of properties of bulk polycrystalline CVD (BPCVD) diamond. The material used in these experiments is synthesized and processed under routine manufacturing conditions rather than as isolated research specimens. Most of the specimens used have been made flat and parallel and have been polished to an optical quality finish. Many of the properties are influenced by surface conditions and it is important to emphasise that after-growth processing is an integral part of what is referred to in this paper as BPCVD diamond specimens. The following properties are reviewed: optical properties; thermal properties; mechanical properties; dielectric properties; and laser induced damage threshold.
Federal Aid for Children and Teachers in all Schools (2016)

1 when President Johnson signed into law the Elementary and Secondary Education Act of 1965.This is the federal education foundation act to strengthen and improve educational opportunities for children in the nation's elementary and secondary schools.It implements the equal protection of the laws principle as unanimously declared by the United States Supreme Court in Brown v. Board of Educ., 2 wherein it was stated:In these days, it is doubtful that any child may reasonably be expected to succeed in life if he is denied the opportunity of an education.Such an opportunity, where the state has undertaken to provide it, is a right which must be made available to all on equal termsA School library resources, textbooks and other instructional materials are authorized by Title II of that Act to be supplied for the use of all children and teachers in public and private elementary and secondary schools.Title II is the clearest example of the formula used by the Johnson administration to win support for the principle of education "for the benefit of all children."This statute is an excellent example of federal educational aid for the child, with a minimum of federal interference in state control of educational facilities.Every federal department and employee is prohibited by the Act from exercising any direction, supervision or control over the curriculum of any educational institution or over the selection of library
Netobjects Fusion 2 for Windows & MacIntosh (Visual QuickStart Guide) (1997)

From the Publisher:
With NetObjects Fusion, designers need not mess with direct HTML coding; instead, everything a Web builder needs is available through intuitive graphic toolbars and menu selections. NetObjects Fusion 2 is a visual program, which fits the easy-to-learn approach taken by this guide. The book moves beyond application-specific discussion to include planning structure, designing look and feel, creating content, and managing a site.
Mechanisms of increased hippocampal excitability in the <i>Mashl</i><sup><i>+/−</i></sup> mouse model of Na<sup>+</sup>/K<sup>+</sup>‐<scp>ATP</scp>ase dysfunction (2018)

Our data indicate that, in our genetic model of Atp1α3 mutation, there is increased excitability and marked dysfunction in GABAergic inhibition. This supports the performance of further investigations to determine if selective expression of the mutation in GABAergic and or glutamatergic neurons is necessary and sufficient to result in the behavioral phenotype.
A survey of circuit innovations in ferroelectric random-access memories (2000)

This paper surveys circuit innovations in ferroelectric memories at three circuit levels: memory cell, sensing and architecture. A ferroelectric memory cell consists of at least one ferroelectric capacitor, where binary data are stored, and one or two transistors that either allow access to the capacitor or amplify its contents for a read operation. Once a cell is accessed for a read operation, its data are presented in the form of an analog signal to a sense amplifier, where it is compared against a reference voltage to determine its logic level. The circuit techniques used to generate the reference voltage must be robust to semiconductor processing variations across the chip and the device imperfections of ferroelectric capacitors. We review six methods of generating a reference voltage, two being presented for the first time in this paper. These methods are discussed and evaluated in terms of their accuracy, area overhead and sensing complexity. Ferroelectric memories share architectural features such as addressing schemes and input/output circuitry with other types of random-access memories such as dynamic random-access memories. However, they have distinct features with respect to accessing the stored data, sensing, and overall circuit topology. We review nine different architectures for ferroelectric memories and discuss them in terms of speed, density and power consumption.
[A morphological study of tissues in the posterior segment of the eye after modified experimental revascularization of the choroid]. (1995)

Morphologic examination of ocular tissues at the site of revascularization with two flaps was carried out to detect the changes in the architectonics of these flaps' vessels, vascular coating at the site of intervention, and assess the formation of relation with the vascular system of the external tissues of the eye. Experiments were carried out on the eyes of 8 cats. All the animals were subjected to local revascularization of the vascular coating with two flaps. Enucleation was carried out 1 to 6 months after the operation. The eyes were fixed in 10% neutral formalin solution, paraffin slices and blocks were prepared, stained with hematoxylin and eosin, with pyrofucin after Van Gieson, and with toluidine blue after Lison. Histologic study of ocular tissue slices 2-3 weeks after surgery showed that the flaps introduced into the supra-arachnoidal space tightly fitted each other forming a subconjunctival-episcleral transplant in which a moderate number of newly formed vessels was detected. Three to six months after surgery vascularization of the transplant proper and around it grew more and more intensive, the number of new vessels increased with their walls looking more compact; basal membrane appeared well shaped. The walls of new vessels did not differ by structure from normal vascular walls in the vascular coating.
하수방류수 내 TOC 제거를 위한 전기분해공정의 최적 조건 (2017)

2013년 환경 정책 개정에 따라 총유기탄소(TOC)항목이 수질 및 수생태계 보전에 관한 법률에 도입되었으며, 이러한 정책 시행에 따라 공공하수처리시설에서의 TOC에 대한 수질관리의 필요성이 대두되었다. 본 연구는 실험실 규모 전기분해공정에서 전기화학적 반응을 이용하여 하수방류수 내 TOC 제거특성을 살펴보았다. 실...
Mg x Zn 1 − x O ( 0 ⩽ x &lt; 0.2 ) nanowire arrays on sapphire grown by high-pressure pulsed-laser deposition (2005)

Mg x Zn 1 − x O nanowires with Mg-content x from 0 to 0.2 have been grown by high-pressure pulsed-laser deposition (PLD) on gold-covered sapphire single crystals. The PLD process allows for a unique wide-range control of morphology, diameter, and composition of the MgxZn1−xO nanowires. The diameter of single ZnO wires could be varied between about 50 and 3000 nm, and the Mg content x of MgxZn1−xO wire arrays was controlled via the PLD gas pressure. The microscopic homogeneity of Mg content is displayed by cathodoluminescence (CL) imaging of the excitonic peak energy. The fluctuation of CL peak energy between individual wires is about an order of magnitude smaller than the alloy broadening.
Modelling performance & resource management in kubernetes (2016)

Containers are rapidly replacing Virtual Machines (VMs) as the compute instance of choice in cloud-based deployments. The significantly lower overhead of deploying containers (compared to VMs) has often been cited as one reason for this. We analyse performance of the Kubernetes system and develop a Reference net-based model of resource management within this system. Our model is characterised using real data from a Kubernetes deployment, and can be used as a basis to design scalable applications that make use of Kubernetes.
Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison (2016)

Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors with high incidence and mortality rate. Precision and effective biomarkers are therefore urgently needed for the early diagnosis and prognostic estimation. MicroRNAs (miRNAs) are important regulators which play functions in various cellular processes and biological activities. Accumulating evidence indicated that the abnormal expression of miRNAs are closely associated with HCC initiation and progression. Recently, many biomarker miRNAs for HCC have been identified from blood or tissues samples, however, the universality and specificity on clinicopathological features of them are less investigated. In this review, we comprehensively surveyed and compared the diagnostic, prognostic, and therapeutic roles of HCC biomarker miRNAs in blood and tissues based on the cancer hallmarks, etiological factors as well as ethnic groups, which will be helpful to the understanding of the pathogenesis of biomarker miRNAs in HCC development and further provide accurate clinical decisions for HCC diagnosis and treatment.
Why does histogram packing improve lossless compression rates? (2002)

The performance of state-of-the-art lossless image coding methods [such as JPEG-LS, lossless JPEG-2000, and context-based adaptive lossless image coding (CALIC)] can be considerably improved by a recently introduced preprocessing technique that can be applied whenever the images have sparse histograms. Bitrate savings of up to 50% have been reported, but so far no theoretical explanation of the fact has been advanced. This letter addresses this issue and analyzes the effect of the technique in terms of the interplay between histogram packing and the image total variation, emphasizing the lossless JPEG-2000 case.
Studies of calmodulin structure: laser Raman spectroscopy of biomolecules. XVII (1983)

The structure of bovine brain calmodulin was probed by using laser Raman spectroscopy to elucidate cation-induced conformational changes in the protein. Local changes, most likely reflecting metal binding but not rearrangement of the peptide backbone, were observed in the presence of calcium or magnesium. A conformational change involving the peptide backbone and secondary structure content of calmodulin was observed only in the presence of calcium. The calcium-induced conformational change in the peptide backbone involves increased alpha helix and beta sheet. This was the only major calcium-specific change observed in the Raman spectrum, which suggests that the flexibility of the backbone conformation may play a critical role in the physiological activity of calmodulin.
Electrophysiological Correlation Underlying the Effects of Music Preference on the Prefrontal Cortex Using a Brain–Computer Interface (2021)

This study aims to research the task of recognising brain activities in the prefrontal cortex that correspond to music at different preference levels. Since task performance regarding the effects of the subjects' favourite music can lead to better outcomes, we focus on the physical interpretation of electroencephalography (EEG) bands underlying the preference level for music. The experiment was implemented using a continuous response digital interface for the preference classification of three types of musical stimuli. The results showed that favourite songs more significantly evoked frontal theta than did the music of low and moderate preference levels. Additionally, correlations of frontal theta with cognitive state indicated that the frontal theta is associated not only with the cognitive state but also with emotional processing. These findings demonstrate that favourite songs can have more positive effects on listeners than less favourable music and suggest that theta and lower alpha in the frontal cortex are good indicators of both cognitive state and emotion.
Energy Band Control of GaAsSb-Based Backward Diodes to Improve Sensitivity of Millimeter-Wave Detection (2010)

The effect of energy band control with varying carrier concentration in GaAsSb-based backward diodes was investigated and diode parameters were analyzed to enhance voltage sensitivity. The backward diodes consisted of a heterojunction of p-GaAs 0.51 Sb 0.49 /i-In 0.52 Al 0.48 As/n-In 0.63 Ga 0.37 As/n-In 0.53 Ga 0.47 As, and they were mostly lattice-matched to an InP substrate. The degree of energy band bending at the depletion layer in n-In 0.63 Ga 0.37 As was varied on the basis of the carrier concentration in the n-In 0.53 Ga 0.47 As band control layer. Voltage sensitivity depends on carrier concentration since the concentration affects the band bending structure at the junction. The parameter analysis indicated that junction capacitance decreased when the carrier concentration in the band control layer decreased. When the carrier concentration in the band control layer was as low as 5×10 18 cm -3 , with the diode mesa at a diameter of 2.0 µm, an unmatched voltage sensitivity of 1495 V/W was obtained.
Graphene Aerogels Decorated with α-FeOOH Nanoparticles for Efficient Adsorption of Arsenic from Contaminated Waters (2015)

Arsenic (As) is the world's most hazardous chemical found in drinking water of many countries; therefore, there is an urgent need for the development of low-cost adsorbents for its removal. Here, we report a highly versatile and synthetic route for the preparation of a three-dimensional (3D) graphene-iron oxide nanoparticle aerogel composite for the efficient removal of As from contaminated water. This unique three-dimensional (3D) interconnected network was prepared from natural graphite rocks with a simple reaction, without the use of harsh chemicals, which combines with the exfoliation of graphene oxide (GO) sheets via the reduction of ferrous ion to form a graphene aerogel composite decorated with iron oxide nanoparticles. The prepared adsorbent showed outstanding absorption performance for the removal of As from contaminated water, because of its high surface-to-volume ratio and characteristic pore network in the 3D architecture. The performed case study using real drinking water contaminated with As under batch conditions showed successful removal of arsenic to the concentration recommended by the World Health Organisation (WHO).
Voice recognition digital cipher lock for smart vehicles (2002)

The implementation of a voice recognition digital cipher lock (VRDCL) for automotive applications. Proposed VRDCZ requires a password and a 4-digit combination to obtain access to the vehicle. The VRDCL's combination may be changed by a separate combination programmer unit. The VRDCL will activate a security system after three failed attempts.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
FDDI-ATM internetworking simulation (2002)

This paper focuses on the use of discrete event simulation techniques for the performance evaluation of FDDI networks interconnected via the ATM WAN. The simulation enables us to obtain relevant data on such performance evaluators as the end-to-end delay and throughput for the traditional TCP/IP traffic over the internetwork. The qualitative analysis provides a basis to formulate the delay and throughput approximations and reveals the intrinsic behaviour of these networks. The detailed network model has been developed in the C language. OPNET, a Unix-based communication systems simulation tool which supports the hierarchical object-oriented model is used in this simulation. The FDDI-ATM internetwork performance results are presented.
Introduction (2021)

In this chapter, the authors introduce core concepts on which the book rests: concern with weight as a culturally constructed problem and the obesity-as-diseased model. The authors describe prevailing attitudes toward bodies and health in the United States today and briefly explain what bariatric surgery is and how it is being used within American medical practices in the twenty-first century. The authors also introduce the project, a multiyear ethnography of a single bariatric program within a clinic; briefly outline their methods and perspectives (grounded in anthropology); and then explain their use of “fat” language throughout the volume.
Heparin and acute renal failure. (1975)

At start of On recovery At start of At end of Gentamicin from illness Gentamicin Gentamicin Effect of gentamicin on renal function (creatinine clearance) in six oliguric patients (left-hand column) and 23 patients with stable renal function (right-hand column).associated with transplant rejection.The authors give no indication as to the renal pathology in four patients whose function deteriorated to such an extent that they re- quired graft nephrectomy or dialysis but im- plied that gentamicin was the causative agent.We suggest that there is a wide gap
Integrated Nanozymes with Nanoscale Proximity for in Vivo Neurochemical Monitoring in Living Brains (2016)

Nanozymes, the nanostructures with enzymatic activities, have attracted considerable attention because, in comparison with natural enzymes, they offer the possibility of lowered cost, improved stability, and excellent recyclability. However, the specificity and catalytic activity of current nanozymes are still far lower than that of their natural counterparts, which in turn has limited their use such as in bioanalysis. To address these challenges, herein we report the design and development of integrated nanozymes (INAzymes) by simultaneously embedding two cascade catalysts (i.e., a molecular catalyst hemin and a natural enzyme glucose oxidase, GOx) inside zeolitic imidazolate framework (ZIF-8) nanostructures. Such integrated design endowed the INAzymes with major advantage in improved catalytic efficiency as the first enzymatic reaction occurred in close (nanoscale) proximity to the second enzyme, so products of the first reaction can be used immediately as substrates for the second reaction, thus overcoming the problems of diffusion-limited kinetics and product instability. The considerable high catalytic activity and stability enabled the INAzymes to efficiently draw a colorimetric detection of glucose with good sensitivity and selectivity. When facilitated with in vivo microdialysis, the INAzyme was successfully used for facile colorimetric visualization of cerebral glucose in the brain of living rats. Moreover, when further combined with microfluidic technology, an integrative INAzyme-based online in vivo analytical platform was constructed. The promising application of the platform was successfully illustrated by continuously monitoring the dynamic changes of striatum glucose in living rats' brain following ischemia/reperfusion. This study developed a useful approach to not only functional nanomaterial design but also advanced platforms developments for diverse targets monitoring.