gebhart/patrepeval huggingface dataset:
Recombinant Rinderpest Vaccines Expressing Membrane-Anchored Proteins as Genetic Markers: Evidence of Exclusion of Marker Protein from the Virus Envelope (2000)

Rinderpest virus (RPV) causes a severe disease of cattle resulting in serious economic losses in parts of the developing world. Effective control and elimination of this disease require a genetically marked rinderpest vaccine that allows serological differentiation between animals that have been vaccinated against rinderpest and those which have recovered from natural infection. We have constructed two modified cDNA clones of the vaccine strain RNA genome of the virus, with the coding sequence of either a receptor site mutant form of the influenza virus hemagglutinin (HA) gene or a membrane-anchored form of the green fluorescent protein (GFP) gene (ANC-GFP), inserted as a potential genetic marker. Infectious recombinant virus was rescued in cell culture from both constructs. The RPVINS-HA and RPVANC-GFP viruses were designed to express either the HA or ANC-GFP protein on the surface of virus-infected cells with the aim of stimulating a strong humoral antibody response to the marker protein. In vitro studies showed that the marker proteins were expressed on the surface of virus-infected cells, although to different extents, but neither was incorporated into the envelope of the virus particles. RPVINS-HA- or RPVANC-GFP-vaccinated cattle produced normal levels of humoral anti-RPV antibodies and significant levels of anti-HA or anti-GFP antibodies, respectively. Both viruses were effective in stimulating protective immunity against RPV and antibody responses to the marker protein in all animals when tested in a cattle vaccination trial.
Mapping hourly dynamics of urban population using trajectories reconstructed from mobile phone records (2018)

Abstract Understanding the spatiotemporal dynamics of urban population is crucial for addressing a wide range of urban planning and management issues. Aggregated geospatial big data have been widely used to quantitatively estimate population distribution at fine spatial scales over a given time period. However, it is still a challenge to estimate population density at a fine temporal resolution over a large geographical space, mainly due to the temporal asynchrony of population movement and the challenges to acquiring a complete individual movement record. In this article, we propose a method to estimate hourly population density by examining the time‐series individual trajectories, which were reconstructed from call detail records using BP neural networks. We first used BP neural networks to predict the positions of mobile phone users at an hourly interval and then estimated the hourly population density using log‐linear regression at the cell tower level. The estimated population density is linearly correlated with population census data at the sub‐district level. Trajectory clustering results show five distinct diurnal dynamic patterns of population movement in the study area, revealing spatially explicit characteristics of the diurnal commuting flows, though the driving forces of the flows need further investigation.
Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo (2013)

ClinicalTrials.gov NCT00317993 NCT00317993.
IANA Allocation Guidelines for the Address Resolution Protocol (ARP) (2009)

This document specifies the IANA guidelines for allocating new values
in the Address Resolution Protocol (ARP). This document also reserves
some numbers for experimentation purposes. The changes also affect
other protocols that employ values from the ARP name spaces.
Modelling of Particle Transport, Erosion and Deposition in Power Plant Gas Paths (2016)

Flow evolving in turbomachinery applications is turbulent and laden with particles, such as dust, ash, dirt, etc. This would affect the behaviour of the turbine components given that solid particles can impact and then bounce off, deposit or erode their surfaces. Erosion and deposition phenomena may seriously affect the components performance, because they alter the blade profile and hence the flow field. It is thus clear that the prediction of these phenomena would be of great help form both design optimization and maintenance of turbomachinery. Besides experiments, in the last decade CFD became one of the main tool for studying flow evolution within turbine components, phenomena that involve them, and prediction of problems. In particle-laden flows, CFD is used to simulate the flow field, but also solid particle transport and dispersion, impact mechanics, adhesion or rebound, and erosion. Several approaches can be used depending on the kind of application studied and information expected. Particle transport can be simulated adopting a single or cluster of particle tracking approach (Crowe et al, 2006). Since to have a statistically independent results a large number of simulated particles is needed, the for-mer approach can be used when the domain size is not too large; moreover the instantaneous flow field is needed, otherwise turbulent dispersion of particles has to be accounted for. The cluster of particles approach (i.e., Particle Cloud Tracking model, Baxter 1989) overcomes some of these problems, since it usually uses a model for particle dispersion, computing very few trajectories to simulate a large number of particles. Particle impact/rebound and deposit/erosion are modelled using one of the available choice. For instance, impact mechanics can be modelled according to the Johnson-Kendall-Roberts theory (1971) if the particle temperature is not large enough to modify the physical properties of the particles, or the Thornton and Ning variation (1997). When the effect of temperature becomes relevant, a temperature based sticking model is used, such as that of Walsh et al. (1990). Erosion can be studied according to the model of Tabackof (1979). Aim of this study is showing how CFD can be used to simulate particle deposition/erosion in all the components of a turbine (i.e. fan, turbine, compressor), and predict the most critical regions of a given component. This will be done introducing the numerical models used for some applications, describing reference test cases, and showing/discussing results.
Laser-induced thermonuclear fusion (1973)

Laser-induced fusion has recently joined magnetic-confinement fusion as a prime prospect for generating controlled thermonuclear power. During the past three years, the Atomic Energy Commission has accelerated the national laser-fusion program more than tenfold, to about $30 million annually, and the Soviet Union has a program of comparable size.
Elucidation of structure-activity relationships of 2-amino-3-benzoylthiophenes: Study of their allosteric enhancing vs. antagonistic activity on adenosine A1 receptors (2000)

Novel 2-amino-3-benzoylthiophene derivatives, with variable substitution on the thiophene as well as benzoyl ring, were synthesized and evaluated both as allosteric enhancers of agonist binding to the rat adenosine A1 receptor, and as antagonists on this receptor. Structural features were identified on the novel derivatives that favored allosteric enhancing activity, such as benzoyl lipophilic substitution and thiophene 4-alkyl substitution. In contrast, antagonistic properties were favored by thiophene 5-bulky substitution. Upon further analysis, a significant correlation was found between antagonistic activity and hydrophobic fragment constants (π values) of substituent R5, in contrast to a negative correlation with those of R4. Comparison of low energy conformations of some of the 2-amino-3-benzoylthiophene derivatives (PD81,723 and 4f) with known adenosine A1 antagonists (theophylline and 8-cyclohexyltheophylline) indicated that thiophene 5-substituents may interact with the same lipophilic domain of the adenosine A1 receptor accommodating 8-substituents of xanthine antagonists. Drug Dev. Res. 49:227–237, 2000. © 2000 Wiley-Liss, Inc.
Design of flexible meandered loop antennas loaded with CSRR and SRR for implantable applications (2016)

The objective of this paper is to present the design of flexible meandered loop antennas which is loaded with CSRR and SRR for implantable application. The design of flexible meander loop antenna is done and then modification is done to propose two antennas. One proposed antenna is loaded with CSRR and other is loaded with SRR. The proposed antennas operates in multiband frequencies like the 402-405 MHz Medical Implant Communication System (MICS) band and the Industrial, Scientific and Medical (ISM) bands which ranges from 433.1-434.8 MHz, 868-868.6 MHz, 902.8-928 MHz, and 2400-2500 MHz which is assigned for medical implantable device application. The introduction of CSRR and SRR in the flexible meandered loop antenna improves the return loss at the desired multiband frequencies. The parametric study is done to obtain the desired return loss at the expected frequency bands. A reduction in the Specific Absorption Rate of the proposed antennas is also observed. The size of the antennas becomes compact as a result of its flexible nature. The dimension of the antennas is 4.5 mm radius and 16mm height which is an acceptable dimension for implantable devices. A comparative study is done and presented in this paper to show the impact of single and dual ring CSRR on the performance of the flexible meandered loop antenna. The parametric study is done to optimize the position of the SRR to get good return loss at desired bands and the comparison of the results is presented in this paper. The designing and simulation of the proposed antennas is done using 3D EM simulation software CST Microwave studio v.15.0.
Amyotrophic Lateral Sclerosis Mortality in the United States, 2011–2014 (2018)

Previous reports of ALS mortality in the United States showed similar age, sex, and race distributions but with greater age-adjusted mortality rates due to the inclusion of other diseases in the case definition. When using ICD-10 data collected prior to 2017, additional review of multiple-cause of death data is required for the accurate estimation of ALS deaths.
Approaches to Stereoselective Dioxygenation of Alkenes:  Chiral Phosphite Ozonides (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTApproaches to Stereoselective Dioxygenation of Alkenes: Chiral Phosphite OzonidesPatrick H. Dussault and Kevin R. WollerView Author Information Department of Chemistry, University of NebraskaLincoln, Lincoln, Nebraska 68588-0304 Cite this: J. Org. Chem. 1997, 62, 5, 1556–1559Publication Date (Web):March 7, 1997Publication History Received12 August 1996Revised8 January 1997Published online7 March 1997Published inissue 1 March 1997https://pubs.acs.org/doi/10.1021/jo961564hhttps://doi.org/10.1021/jo961564hbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views810Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Hydrocarbons,Oxidation,Oxides,Saturation Get e-Alerts
Analysis and synthesis of neural networks with lower block triangular interconnecting structure (1990)

A qualitative analysis of Hopfield-type neural network models with lower block triangular interconnecting structure is presented. Such networks are viewed as interconnected systems and the results are phrased in terms of the qualitative properties of the subsystems of the networks and in terms of the properties of the interconnecting structure of the networks. The results address the stability properties of equilibrium points and estimates of trajectory properties. A design method is devised for this class of neural networks to establish desired relationships between scalar-valued analog input signals and output signals in binary form. The applicability of the design methodology is demonstrated by means of several specific examples, including the design of an A/D converter, the design of a resistor sorter, and the design of a resister tolerancer. Specific simulations show that the present design method offers significant improvements over other design techniques that employ Hopfield neural networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue. (1994)

These data suggest that, even when given in high oral doses, N-acetyl cysteine does not produce a sustained increase in glutathione levels sufficient to increase the antioxidant capacity of the lungs.
Compression Algorithms for Real Programmers (1999)

Preface. Book Notes. Introduction. Statistical Basics. Dictionary Techniques. Arithmetic Compression. Adaptive Compression. Grammar Compression. Programmatic Solutions. Quantization. Wavelet Transforms. JPEG. Video Compression. Audio Compression. Fractal Compression. Steganography. Appendix A: Patents. Appendix B: Bibliography. Index.
Optimal load balancing algorithms for Jacksonian networks with acknowledgement delays (2003)

The load-balancing problem for centralized Jacksonian networks is investigated. The networks are subject to end-to-end flow control with nonzero acknowledgement delay. To analyze these networks, a closed queuing network controlled by a queue with a variable service rate is investigated. The load balancing problem is reduced to one of combined routing and flow control. The objective is to maximize the throughput of the network such that the end-to-end expected time delay does not exceed an upper bound. The optimal routing balances the traffic in the network, and the optimal flow-control policy guarantees the upper bound constraint. Iterative algorithms that derive the optimal routing and flow-control parameters are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development of Novel Multifunctional Cosmetic Raw Materials and Their Applications. III.<sup>&dagger;</sup> Effect of Random Copolymer of Polyoxyethylene/polyoxypropylene on Self-organizing Structures of Nonionic Surfactants (2006)

In this study, the effect of polyoxyethylene (POE)/polyoxypropylene (POP) dimethylethers [EPDMEs] with various molecular weights and polarities on self-organizing structures of pentaethyleneglycol dodecylether (C12E5) was investigated. The investigation on micelle formation of C12E5 in EPDME aqueous solutions showed that [1] EPDME disturbed the micelle formation of C12E5, [2] the micelle formation was also disturbed more strongly with the increase of temperature, and [3] the surface tension of solution became low in spite of the decrease of the amount of adsorption of C12E5 with the increase of the concentration of EPDME. The result of measuring the cloud points of C12E5 in EPDME solutions unveiled that the cloud points became remarkably higher at high EPDME concentration, suggesting that the rise of the cloud points in EPDME solutions might be caused by the decrease of the aggregation number of C12E5. Moreover, it was speculated that C12E5 and EPDME might aggregate partially and form mixed micelles, since the cloud points of their mixture appeared beyond 50 °C. Liquid paraffin could be solubilized at a specific temperature above the could point of C12E5 in 27wt% EPDME (17/4) aqueous solution. It was speculated that [1] a special micelle containing oil might be formed when the cohesive force of the hydrophobic groups of C12E5 increased by solubilizing liquid paraffin, [2] EPDME distributed to the hydrophilic chain of C12E5, and [3] the curvature of the interfacial film became positive. Therefore, as described in the previous study, EPDME functions as a hydrophilic co-surfactant when the concentrations of both EPDME and polyoxyethylene nonionic surfactants are high, because EPDME may probably distribute on the polyoxyethylene chain of the surfactant. A microemulsion can be formed in a wide temperature range by preventing the aggregation of nonionic surfactants with the increase of temperature.
A DPCM System Based on a Composite Image Model (1983)

This paper presents a DPCM system for storage or transmission (via noiseless channel) of a moving (3-D) TV image. A fully nonlinear(adaptive) DPCM system based on a composite model of the image fragment is described. The description takes into consideration mutual influence of the prediction and quantization parts of the system. New results are presented concerning the probability density functions of the image luminance and the prediction error. The paper also addresses two types of system optimization: 1) minimization of the mean square quantization error (MSQE); 2) minimization of the MSQE when the entropy of the quantizer output is below a specified level. The results of the optimization determine the parameters of the system.
Recent progress in catalytic NO decomposition (2016)

Recent progress in catalytic direct NO decomposition is overviewed, focusing on metal oxide-based catalysts. Since the discovery of the Cu-ZSM-5 catalyst in the early 1990s, various kinds of catalytic materials such as perovskites, C-type cubic rare earth oxides, and alkaline earth based oxides have been reported to effectively catalyze direct NO decomposition. Although the activities of conventional catalysts are poor in the presence of coexisting O 2 and CO 2 , some of the catalysts reviewed in this article possess significant tolerance toward these coexisting gases. The active sites for direct NO decomposition are different depending on the types of metal oxide-based catalysts. In the case of perovskite type oxides, oxide anion vacancies act as catalytically active sites on which NO molecules are adsorbed. C-type cubic rare earth oxides contain oxide anion vacancies with large cavity space, enabling easy access of NO molecules and their subsequent adsorption. Surface basic sites on alkaline earth based oxides participate in NO decomposition as active sites on which NO molecules are adsorbed as NO 2 − species. The reaction mechanisms of direct NO decomposition are also discussed.
Prevalence of BTK and PLCG2 mutations in a real-life CLL cohort still on ibrutinib after 3 years: a FILO group study (2019)

Mutational analyses performed following acquired ibrutinib resistance have suggested that chronic lymphocytic leukemia (CLL) progression on ibrutinib is linked to mutations in Bruton tyrosine kinase (<i>BTK</i>) and/or phospholipase Cγ2 (<i>PLCG2</i>) genes. Mutational information for patients still on ibrutinib is limited. We report a study aimed to provide a "snapshot" of the prevalence of mutations in a real-life CLL cohort still on ibrutinib after at least 3 years of treatment. Of 204 patients who initiated ibrutinib via an early-access program at 29 French Innovative Leukemia Organization (FILO) centers, 63 (31%) were still on ibrutinib after 3 years and 57 provided a fresh blood sample. Thirty patients had a CLL clone ≥0.5 × 10<sup>9</sup>/L, enabling next-generation sequencing (NGS); <i>BTK</i> and <i>PLCG2</i> mutations were detected in 57% and 13% of the NGS samples, respectively. After median follow-up of 8.5 months from sample collection, the presence of a <i>BTK</i> mutation was significantly associated with subsequent CLL progression (<i>P</i> = .0005 vs no <i>BTK</i> mutation). Our findings support that mutational analysis should be considered in patients receiving ibrutinib who have residual clonal lymphocytosis, and that clinical trials are needed to evaluate whether patients with a <i>BTK</i> mutation may benefit from an early switch to another treatment.
Flying edges: A high-performance scalable isocontouring algorithm (2015)

Isocontouring remains one of the most widely used visualization techniques. While a plethora of important contouring algorithms have been developed over the last few decades, many were created prior to the advent of ubiquitous parallel computing systems. With the emergence of large data and parallel architectures, a rethinking of isocontouring and other visualization algorithms is necessary to take full advantage of modern computing hardware. To this end we have developed a high-performance isocontouring algorithm for structured data that is designed to be inherently scalable. Processing is performed completely independently along edges over multiple passes. This novel algorithm also employs computational trimming based on geometric reasoning to eliminate unnecessary computation, and removes the parallel bottleneck due to coincident point merging. As a result the algorithm performs well in serial or parallel execution, and supports heterogeneous parallel computation combining data parallel and shared memory approaches. Further it is capable of processing data too large to fit entirely inside GPU memory, does not suffer additional costs due to preprocessing and search structures, and is the fastest non-preprocessed isocontouring algorithm of which we are aware on shared memory, multi-core systems. The software is currently available under a permissive, open source licence in the VTK visualization system.
IP mobility to support live migration of virtual machines across subnets (2009)

User-transparent live migration is one of the most interesting features of Virtual Machine (VM) environments. Current live-migration technologies require that the VM retains its IP network address; therefore, are typically restricted to movement within an IP subnet. The growing number of portable computing devices has led to the development of IP mobility solutions that enable uninterrupted network connectivity while moving between different IP subnets. In this paper we study the application of current network mobility approaches to VM cross-subnet live-migration. We show that although the core problems are similar, there are significant differences between these domains, in terms of both assumptions and requirements. We present a specific solution for live migration of a VM across IP subnets, and introduce a new framework for synchronizing migration and network configuration, which allows better optimization for different scenarios of live migration.