gebhart/patrepeval huggingface dataset:
Low Protein Diets Improve Survival from Peritonitis in Guinea Pigs (1989)

Enteral diets with different protein content were tested to determine their effect on outcome in a model of protracted bacterial peritonitis. Hartley guinea pigs were provided with gastrostomies, and 1 week later, osmotic pumps were implanted into the peritoneal cavity to allow for continuous release of live bacteria over the course of 1 week. Three days after pump implantation, the animals began receiving isocaloric enteral diets that contained 5%, 10%, 15%, or 20% of total calories as protein. After 2 weeks of observation, the survivors were killed. All animals lost weight during the 2-weeks period, but there was no difference in weight lost. Nitrogen balance correlated with dietary protein. The mortality rate was significantly higher in the groups that received 15% and 20% of total calories compared with the group that received 5% (p less than 0.05). Although dietary protein in the 5% group was insufficient for meeting the nutritional needs of the animal, survival was best in this group. Possible explanations are that protein restriction in this model may either augment host defence or impair bacterial virulence.
1.5 μm band efficient broadband wavelength conversion by difference frequency generation in a periodically domain-inverted LiNbO3 channel waveguide (1993)

Efficient 1.5 μm band wavelength conversion by difference frequency generation (DFG) in a periodically domain-inverted LiNbO3 channel waveguide is demonstrated, and DFG efficiency as high as 40% W−1 cm−2 is obtained. Nearly constant wavelength conversion efficiency has been confirmed over a broad wavelength range of 30 nm, which is the largest value ever reported.
Global patterns of gene expression in rice cultivars undergoing a susceptible or resistant interaction with the parasitic plant <i>Striga hermonthica</i> (2008)

• Striga hermonthica is a root hemiparasite of cereals that causes devastating loss of yield. Recently, a rice cultivar, Nipponbare, was discovered, which exhibits post-attachment resistance to this parasite and quantitative trait loci (QTL) associated with the resistance were identified. • Changes in gene expression in susceptible (IAC 165) and resistant (Nipponbare) rice cultivars were profiled using rice whole-genome microarrays. In addition to a functional categorization of changes in gene expression, genes that were significantly up-regulated within resistance QTL were identified. • The resistance reaction was characterized by up-regulation of defence genes, including pathogenesis-related proteins, pleiotropic drug resistance ABC transporters, genes involved in phenylpropanoid metabolism and WRKY transcription factors. These changes in gene expression resemble those associated with resistance to microbial pathogens. Three genes encoding proteins of unknown function, within a major resistance QTL on chromosome 12, were highly up-regulated and are excellent candidate resistance genes. • The susceptible interaction was characterized by large-scale down-regulation of gene expression, particularly within the functional categories plant growth regulator signalling and metabolism, biogenesis of cellular components and cell division. Up-regulated genes included nutrient transporters, enzymes of amino acid metabolism and some abiotic stress genes.
A 3D-Deep-Learning-based Augmented Reality Calibration Method for Robotic Environments using Depth Sensor Data (2020)

Augmented Reality and mobile robots are gaining increased attention within industries due to the high potential to make processes cost and time efficient. To facilitate augmented reality, a calibration between the Augmented Reality device and the environment is necessary. This is a challenge when dealing with mobile robots due to the mobility of all entities making the environment dynamic. On this account, we propose a novel approach to calibrate Augmented Reality devices using 3D depth sensor data. We use the depth camera of a Head Mounted Augmented Reality Device, the Microsoft Hololens, for deep learning-based calibration. Therefore, we modified a neural network based on the recently published VoteNet architecture which works directly on raw point cloud input observed by the Hololens. We achieve satisfying results and eliminate external tools like markers, thus enabling a more intuitive and flexible work flow for Augmented Reality integration. The results are adaptable to work with all depth cameras and are promising for further research. Furthermore, we introduce an open source 3D point cloud labeling tool, which is to our knowledge the first open source tool for labeling raw point cloud data.
Predictors of quality of life in patients evaluated for liver transplantation (2014)

Actual liver function is not related to decreased quality of life, whereas ascites and hypoproteinemia represent the major factors influencing physical and social aspects of daily life in potential liver transplant candidates.
Stability of WAIS-R scatter indices in the elderly (1996)

The test-retest reliability and clinical stability of WAIS-R VIQ-PIQ differences, inter, and intrasubtest scatter were investigated in a sample of 61 normal persons 75 years and older. The test-retest coefficient was .76 for VIQ-PIQ discrepancy, ranged from .05 to .56 for the intersubtest scatter range, and from .08 to .43 for intrasubtest scatter. In terms of clinical stability, 56% of subjects maintained a similar magnitude and direction of meaningful VIQ-PIQ differences from test to retest. Classification of subtest strengths and weakness from test to retest was generally poor with an average disagreement of 52% from the first to the second assessment. Intrasubtest scatter also displayed poor clinical stability with 25–50% of subjects demonstrating meaningful changes on retest.
The Circuit Design of Touch-sensing Wireless Mouse Based on MEMS (2011)

This article introduces a design of multi-function wireless mouse based on the combination of the MEMS accelerometer sensor,touch sense technology and RF technology.By analyzing the electrical properties and functions of electronic compo-nents on the circuit,a simple and feasible design is proposed,which is also low cost in the materials.The new design has made up the shortfall while designing the traditional mouse.
Antitumor Potency of an Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, Lisocabtagene Maraleucel in Combination With Ibrutinib or Acalabrutinib (2020)

Chimeric antigen receptor (CAR) T-cell therapy is a promising treatment for patients with CD19 B-cell malignancies. Combination strategies that improve CAR T-cell potency, limit tumor environment-mediated immune dysfunction, and directly reduce tumor burden may increase the potential for durable clinical benefit of CAR T-cell therapy. Lisocabtagene maraleucel (liso-cel) is a product therapy candidate being tested in patients with relapsed/refractory non-Hodgkin lymphoma or chronic lymphocytic leukemia. This study assessed the in vitro and in vivo functionality of CAR T cells transduced to express the anti-CD19 CAR of liso-cel in combination with ibrutinib or acalabrutinib. In prolonged stimulation assays, the presence of ibrutinib or acalabrutinib improved the CAR T-cell effector function. RNA-Seq analysis and surface marker profiling of these CAR T cells treated with ibrutinib but not acalabrutinib revealed gene expression changes consistent with skewing toward a memory-like, type 1 T-helper, Bruton tyrosine kinase phenotype. Ibrutinib or acalabrutinib improved CD19 tumor clearance and prolonged survival of tumor-bearing mice when used in combination with CAR T cells. A combination of the defined cell product therapy candidate, liso-cel, with ibrutinib or acalabrutinib is an attractive approach that may potentiate the promising clinical responses already achieved in CD19 B-cell malignancies with each of these single agents.
Endopeptidase Cleavage Generates a Functionally Distinct Isoform of C1q/Tumor Necrosis Factor-related Protein-12 (CTRP12) with an Altered Oligomeric State and Signaling Specificity (2012)

Adipose tissue-derived adipokines are an important class of secreted metabolic regulators that mediate tissue cross-talk to control systemic energy balance. We recently described C1q/TNF-related protein-12 (CTRP12), a novel insulin-sensitizing adipokine that regulates glucose metabolism in liver and adipose tissue. However, the biochemical properties of CTRP12 and its naturally occurring cleaved isoform have not been characterized. Here, we show that CTRP12 is a secreted hormone subjected to multiple functionally relevant posttranslational modifications at highly conserved residues. For example, Asn(39) is glycosylated, whereas Cys(85) mediates the assembly of higher order oligomeric structure. Endopeptidase cleavage at Lys(91) generates a cleaved globular gCTRP12 isoform, the expression of which is increased by insulin. PCSK3/furin was identified as the major proprotein convertase expressed by adipocytes that mediates the endogenous cleavage of CTRP12. Cleavage at Lys(91) is context-dependent: mutation of the charged Arg(93) to Ala on the P2' position enhanced cleavage, and triple mutations (K90A/K91A/R93A) abolished cleavage. Importantly, the two isoforms of CTRP12 differ in oligomeric structures and are functionally distinct. The full-length protein forms trimers and larger complexes, and the cleaved isoform consisted of predominantly dimers. Whereas full-length fCTRP12 strongly activated Akt signaling in H4IIE hepatocytes and 3T3-L1 adipocytes, gCTRP12 preferentially activated MAP kinase (ERK1/2 and p38 MAPK) signaling. Further, only fCTRP12 improved insulin-stimulated glucose uptake in adipocytes. These results reveal a novel mechanism controlling signaling specificity and function of a hormone via cleavage-dependent alteration in oligomeric state.
Einleitung (2002)

In einer unsicheren Welt sind Produzenten vielfältigen Risiken ausgesetzt. Eine besondere Art von Risiko entsteht dadurch, daß die Absatzpreise der Erzeugnisse, insbesondere bei langfristigen Produktionsprozessen, möglichen Änderungen unterworfen sind. Diese im folgenden als „Preisrisiko“ beziehungsweise „Preisänderungsrisiko“ bezeichnete Unsicherheit bildet den Ausgangspunkt für die vorliegende Arbeit.
Identification of cytochrome P450 heme motif in plants proteome (2013)

Plant cytochrome (CYP) P450 monooxygenases are heme-containing enzymes that take part in the production of a wide variety of secondary products, a number of which are inhibitory to the survival of insects, pathogens and vertebrate herbivores. Main class of characterized natural plant compounds terpenoids are mostly substrates for plant CYPs. Metabolic engineering of plants using genetic modification of the P450 enzymes has remarkable implications for molecular farming of natural plant chemicals used as pharmaceuticals, disease and insect deterrents. However, molecular information regarding the metabolism of herbicides by plant CYPs is limited and most detoxifying CYPs are expressed at low levels in plants. Therefore, identification of plant CYP enzymes may help in characterization and increase in expression levels followed by design of herbicide-resistant plants. Therefore, in this study we have developed a method to explore the available plant's proteome for the identification of CYPs on the basis of conserved heme motif. For this we have used position-specific scoring matrix method and correlated the availability of CYPs on the basis of heme motif distribution. We have identified the proteome-wide CYPs on the basis of occurrence and positional arrangements of heme motif in the publicly available nine plant's proteome viz., Arabidopsis thaliana, Vitis vinifera, Zea mays, Triticum aestivum, Sorghum bicolor, Glycine max, Brassica napus, Brassica oleracea, and Solanum lycopersicum. Results showed that V. vinifera and A. thaliana have high conservation of heme motif in CYP enzymes as well as hypothetical sequences i.e., 88.46%, therefore characterizations of CYP enzymes from these prioritized plants may help to increase the CYPs expression levels followed by design of resistant plants. Among the heme motif sequence, three most variable amino acids i.e., alanine, isoleucine and proline can be targeted to enhance the possibility of functional role in the biosynthesis of secondary metabolites and consequently may increase the production of phytochemicals as a precursor for synthesis of active molecules for drug discovery and phytoremediation.
Flavodoxin Mutants of <i>Escherichia coli</i> K-12 (2000)

The flavodoxins are flavin mononucleotide-containing electron transferases. Flavodoxin I has been presumed to be the only flavodoxin of Escherichia coli, and its gene, fldA, is known to belong to the soxRS (superoxide response) oxidative stress regulon. An insertion mutation of fldA was constructed and was lethal under both aerobic and anaerobic conditions; only cells that also had an intact (fldA(+)) allele could carry it. A second flavodoxin, flavodoxin II, was postulated, based on the sequence of its gene, fldB. Unlike the fldA mutant, an fldB insertion mutant is a viable prototroph in the presence or absence of oxygen. A high-copy-number fldB(+) plasmid did not complement the fldA mutation. Therefore, there must be a vital function for which FldB cannot substitute for flavodoxin I. An fldB-lacZ fusion was not induced by H(2)O(2) and is therefore not a member of the oxyR regulon. However, it displayed a soxS-dependent induction by paraquat (methyl viologen), and the fldB gene is preceded by two overlapping regions that resemble known soxS binding sites. The fldB insertion mutant did not have an increased sensitivity to the effects of paraquat on either cellular viability or the expression of a soxS-lacZ fusion. Therefore, fldB is a new member of the soxRS (superoxide response) regulon, a group of genes that is induced primarily by univalent oxidants and redox cycling compounds. However, the reactions in which flavodoxin II participates and its role during oxidative stress are unknown.
A indústria petroquímica no próximo século: como substituir o petróleo como matéria-prima? (2001)

Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual hace más accesibles los libros digitales de tema americanista a los investigadores y usuarios interesados de cualquier parte del mundo.
Mikrosysteme für die Biotechnologie (2000)

Abstract Die Chiptechnologie beschränkt sich längst nicht mehr auf die elektronische Mess‐ und Informationstechnik. Mit Mikrochips ist es heute gleichermaßen möglich, biologische Information zu entziffern und zu bearbeiten, zum Beispiel bei der DNA‐Sequenzierung. Anstelle von Festkörpern, metallischen Leiterbahnen und Schaltkreisen müssen dabei Flüssigkeiten, Moleküle und Zellen adressiert und prozessiert werden. Nicht allein wissenschaftliches und technisches Interesse treibt diese Entwicklung voran. Die Probleme der Welternährung und Weltgesundheit, Klimaschutz und Artenschutz, ökologisches Leben und Produzieren werden ohne Kenntnis und Beherrschung der molekularen Basis lebender Systeme nicht zu bewältigen sein. Die Miniaturisierung biomolekularer Prozesse und der Aufbau von Schnittstellen zwischen der biomolekularen Welt und der digitalelektronischen Welt sind Herausforderungen für die Biotechnologie, die mit der Handhabung kleinster Stoffmengen beginnen.
Inhibition of immunological histamine release from guinea pig lungs and other organs by mepyramine, ketotifen, and picumast in vivo. (1989)

The effect of mepyramine, ketotifen and picumast (3,4-dimethyl-7-[4-(4-chlorobenzyl)piperazine-1-yl]propoxycoumarin dihydrochloride) on anaphylactic histamine release from lungs, heart, stomach, and intestine of guinea pigs in response to antigen was examined in vivo. When sensitized animals were pretreated intraperitoneally with a single dose of these compounds 60 min before i.v. antigen challenge (native ovalbumin 20 mg/kg), a dose related inhibition of immunological histamine release from the lung was established. After pretreatment of the animals with 3 mg/kg of mepyramine, 10 mg/kg of ketotifen, and 6 mg/kg of picumast dihydrochloride, the inhibitory effect on histamine release from the lung was so marked that both the acute and the protracted anaphylactic shock were completely suppressed. The corresponding histamine levels in blood plasma, regularly measured 1.5 min after antigen stimulation, had dropped to about 40%, 50%, and 35%, respectively (p less than 0.05), whereas lung histamine content increased by about 60%, 150%, and 90% compared with unpretreated, shocked controls. According to these findings the number of lung mast cells in protected animals was significantly increased. In addition, ketotifen significantly reduced histamine release from heart and intestine. In contrast the compound injected intravenously 1 min before antigen challenge had no effect on mast cell degranulation and on histamine liberation, thus only decreasing the acute anaphylactic bronchospasm. These data suggest that all three drugs were acting as H1-antagonists when administered immediately prior to the antigen-provoked anaphylactic reaction. The property of these drugs to inhibit mast cell degranulation and the reduction of mediator release, however, appears to depend on their prolonged action on these cells. Together with their histamine antagonism anaphylactic death is thus prevented.
Perioperative Fluid Management (2008)

ABSTRACT Technological advances have changed how traditional surgical procedures are performed. New knowledge and surgical skills are required to effectively monitor the patient and manage fluids administered perioperatively. Today, selective fluids are used in a variety of surgical specialties. Complications of fluid therapy can occur that are intrinsic to each procedure within a specialty. This article provides perioperative nurses with the information needed to evaluate different fluid media and their applications and identify patient care considerations. Possible complications and important postanesthesia care concerns also are discussed. AORN J 89 (January 2009) 167–178. © AORN, Inc, 2009.
Kahweol and cafestol: Inhibitors of hamster buccal pouch carcinogenesis (1991)

Kahweol and cafestol, two compounds extracted from green coffee beans, were tested for cancer chemopreventive activity. For the experiment, 60 hamsters were divided into three equal groups and placed on one of three diets. The animals in Group I received a normal diet, whereas the animals in Groups II and III received the same diet supplemented with a 50:50 mixture of kahweol and cafestol. The content of the kahweol and cafestol mixture in these two diets was 0.2 g/kg of food (Group II) and 2.0 g/kg of food (Group III). After the hamsters adjusted to their respective diets, 16 hamsters from each group were selected. The left buccal pouches of these animals were painted three times weekly with a 0.5% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in mineral oil. The 12 remaining hamsters were used as controls. The left buccal pouches of these animals were painted three times weekly with mineral oil. After 13 weeks (39 applications) the hamsters were killed. Multiple tumors were common in animals treated with DMBA; however, the animals receiving kahweol and cafestol in the diet (2 g/kg of food) exhibited a 35% reduction in tumor burden. Further comparisons between Groups I and III showed that this reduction in tumor burden was due to a decrease in tumor number. The results for Group II were inconclusive. Some reduction in tumor number was found, but this was offset by an increase in the size of the tumors.
Reimagining Druggability Using Chemoproteomic Platforms (2021)

One of the biggest bottlenecks in modern drug discovery efforts is in tackling the undruggable proteome. Currently, over 85% of the proteome is still considered undruggable because most proteins lack well-defined binding pockets that can be functionally targeted with small molecules. Tackling the undruggable proteome necessitates innovative approaches for ligand discovery against undruggable proteins as well as the development of new therapeutic modalities to functionally manipulate proteins of interest. Chemoproteomic platforms, in particular activity-based protein profiling (ABPP), have arisen to tackle the undruggable proteome by using reactivity-based chemical probes and advanced quantitative mass spectrometry-based proteomic approaches to enable the discovery of "ligandable hotspots" or proteome-wide sites that can be targeted with small-molecule ligands. These sites can subsequently be pharmacologically targeted with covalent ligands to rapidly discover functional or nonfunctional binders against therapeutic proteins of interest. Chemoproteomic approaches have also revealed unique insights into ligandability such as the discovery of unique allosteric sites or intrinsically disordered regions of proteins that can be pharmacologically and selectively targeted for biological modulation and therapeutic benefit. Chemoproteomic platforms have also expanded the scope of emerging therapeutic modalities for targeted protein degradation and proteolysis-targeting chimeras (PROTACs) through the discovery of several new covalent E3 ligase recruiters. Looking into the future, chemoproteomic approaches will unquestionably have a major impact in further expansion of existing efforts toward proteome-wide ligandability mapping, targeted ligand discovery efforts against high-value undruggable therapeutic targets, further expansion of the scope of targeted protein degradation platforms, the discovery of new molecular glue scaffolds that enable unique modulation of protein function, and perhaps most excitingly the development of next-generation small-molecule induced-proximity-based therapeutic modalities that go beyond degradation. Exciting days lie ahead in this field as chemical biology becomes an increasingly major driver in drug discovery, and chemoproteomic approaches are sure to be a mainstay in developing next-generation therapeutics.
Contaminación acústica: solucións para mellorar o noso contorno (2011)

No noso contorno existe unha problematica importante e moitas veces desconecida como e a contaminacion acustica. Sinxelas consideracions permitirian dar solucion, en maior ou menor medida, a este problema. De feito, segundo a Organizacion Mundial da Saude (OMS), actualmente Espana e o segundo pais do mundo que mais ruido presenta; so superado por Xapon. No presente artigo amosanse distintas solucions de uso cotian para reducir este tipo de contaminacion con exemplos graficos de medidas adoptadas na nosa Comunidade. Faise, ademais, un breve repaso a dous aspectos fundamentais para dar solucion a este problema: o tipo de materiais que se deben empregar e onde se deben situar. Asemade, presentase unha nova alternativa nacida en Galiza no marco da normativa vixente e do tan ansiado desenvolvemento sostibel consistente no aproveitamento dun dos nosos recursos naturais renovabeis (a biomasa) para controlar os ruidos.
Insider Threat Detection Using Virtual Machine Introspection (2013)

This paper presents a methodology for signaling potentially malicious insider behavior using virtual machine introspection (VMI). VMI provides a novel means to detect potential malicious insiders because the introspection tools remain transparent and inaccessible to the guest and are extremely difficult to subvert. This research develops a four step methodology for development and validation of malicious insider threat alerting using VMI. A malicious attacker taxonomy is used to decompose each scenario to aid identification of observables for monitoring for potentially malicious actions. The effectiveness of the identified observables is validated using two data sets. Results of the research show the developed methodology is effective in detecting the malicious insider scenarios on Windows guests.