gebhart/patrepeval huggingface dataset:
Glyproline peptide family: review on bioactivity and possible origins (2002)

Glyproline peptide family includes the simplest proline-containing linear peptides PG, GP, PGP, respective peptides with hydroxylated proline residues and (with some restriction) cyclic PG. Having close structural resemblance they display many similar bioactivities. The suppression of some reactions of blood coagulation and platelet aggregation and protection of gastric mucosa against various ulcerogenic factors are the most important glyproline effects. Glyprolines have two common putative sources: (1) collagen and elastin synthesis and catabolism, and (2) penetration of proline-containing di- and tripeptides from food protein hydrolysate from the intestine into bloodstream. Possible physiological and biochemical mechanisms of glyproline bioactivities are under discussion.
Energy Dissipation and the Fracture of Rubber Vulcanizates (1991)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Gary R. Hamed; Energy Dissipation and the Fracture of Rubber Vulcanizates. Rubber Chemistry and Technology 1 July 1991; 64 (3): 493–500. doi: https://doi.org/10.5254/1.3538566 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search
Groundwater Observations at KSM Site in Northeast Japan, a Most Sensitive Site to Earthquake Occurrence (1990)

Intensive observations of groundwater, including measurements of the radon concentration, water level, and in situ temperature of the aquifer, have been carried out to study their relationship with earthquake occurrence. Analysis of the data of the KSM site located on a fracture zone for the period Janauary 1989-May 1990 suggest a decrease at coseismic radon change. This is attributed to the occurrence of five large earthquakes in succession in the near-by area between February and April 1987
Ambulatory accelerometry to quantify motor behaviour in patients after failed back surgery: a validation study (1998)

In the treatment of patients with pain, measures related to (pain) behaviour are of major importance. Ambulatory activity monitoring can be used to obtain insight into actual behaviour. This study was designed to validate the Activity Monitor (AM), an instrument based on long-term ambulatory monitoring of accelerometer signals, to assess several physical activities during normal daily life. Ten failed back surgery (FBS) patients performed a number of functional activities in and around their own houses. During the measurements, continuous ambulatory registrations of accelerometer signals were made, based on four body-mounted accelerometers (one on each upper leg, two on the trunk). Video recordings made simultaneously with the measurements were used as a reference. The continuous output of the AM (postures, transitions, dynamic activities) was compared with visual analysis of the videotapes. The overall results showed an agreement between AM output and video analysis of 87% (inter subject range: 83-88%). The maximal error in the determination of the duration of activities was 0.3%. The overall number of dynamic periods was determined well (AM: 359; video: 368), while the number of transitions was slightly overestimated (AM: 228; video: 205). The results when using the three-sensor version of the AM were somewhat less accurate (overall agreement from 87% to 82%). The AM appeared to be a valid instrument to quantify aspects of behaviour of FPS patients, such as duration of activities and number of transitions. This new technique of ambulatory measurement of mobility activities seems to be a relevant and promising extension of the techniques currently used in the evaluation of pain treatment.
Tailored Shielding and Bypass Testing of Web Applications (2011)

User input validation is a technique to counter attacks on web applications. In typical client-server architectures, this validation is performed on the client side. This is inefficient because hackers bypass these checks and directly send malicious data to the server. User input validation thus has to be duplicated from the client-side (HTML pages) to the server-side (PHP or JSP etc.). We present a black-box approach for shielding and testing web application against bypass attacks. We automatically analyze HTML pages in order to extract all the constraints on user inputs in addition to the JavaScript validation code. Then, we leverage these constraints for an automated synthesis of a shield, a reverse-proxy tool that protects the server side. The originality and main contribution of this paper is to offer a solution specifically tailored to the web application, through a preliminary learning/analysis step. An experimental study on several open-source web-applications evaluates the effectiveness of the protection tool and the different flaws detected by the testing too and the impact of the shield on performance.
Light Sheet-based Fluorescence Microscopy of Living or Fixed and Stained <em>Tribolium castaneum</em> Embryos (2017)

The red flour beetle Tribolium castaneum has become an important insect model organism in developmental genetics and evolutionary developmental biology. The observation of Tribolium embryos with light sheet-based fluorescence microscopy has multiple advantages over conventional widefield and confocal fluorescence microscopy. Due to the unique properties of a light sheet-based microscope, three dimensional images of living specimens can be recorded with high signal-to-noise ratios and significantly reduced photo-bleaching as well as photo-toxicity along multiple directions over periods that last several days. With more than four years of methodological development and a continuous increase of data, the time seems appropriate to establish standard operating procedures for the usage of light sheet technology in the Tribolium community as well as in the insect community at large. This protocol describes three mounting techniques suitable for different purposes, presents two novel custom-made transgenic Tribolium lines appropriate for long-term live imaging, suggests five fluorescent dyes to label intracellular structures of fixed embryos and provides information on data post-processing for the timely evaluation of the recorded data. Representative results concentrate on long-term live imaging, optical sectioning and the observation of the same embryo along multiple directions. The respective datasets are provided as a downloadable resource. Finally, the protocol discusses quality controls for live imaging assays, current limitations and the applicability of the outlined procedures to other insect species. This protocol is primarily intended for developmental biologists who seek imaging solutions that outperform standard laboratory equipment. It promotes the continuous attempt to close the gap between the technically orientated laboratories/communities, which develop and refine microscopy methodologically, and the life science laboratories/communities, which require 'plug-and-play' solutions to technical challenges. Furthermore, it supports an axiomatic approach that moves the biological questions into the center of attention.
A simulator for a light field display (2017)

A simulator which can test the visual perception response of light field displays is introduced. The simulator can provide up to 8 view images to each eye simultaneously to test the differences between different numbers of different view images in supermultiview condition. The images are going through a window with 4 mm width, which is located at the pupil plane of each eye. Since each view image has its own slot in the window, the image is separately entring the eye without overlapping with other images. The simulator shows that the vergence response of viewers' eyes for an image at a certain distance is closer to the real object of the same distance for 4 views than 2 views. This informs that the focusable depth range will increase more as the the number of different view images increases.
An architecture for outdoor wearable computers to support augmented reality and multimedia applications (2003)

This paper describes an architecture to support a hardware and software platform for research into the use of wearable computers and augmented reality in an outdoor environment. The architecture supports such devices as a GPS, compass, and head-mounted display. A prototype system was built to support novel applications by drawing graphics (such as maps, building plans, and compass bearings) on the head-mounted display, projecting information over that normally seen by the user and hence augmenting a user's perception of reality. This paper presents a set of novel augmented reality and multimedia applications operated in an outdoor environment.
Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice (2019)

PGRN deficiency exacerbates SCI by promoting neuroinflammation and cellular apoptosis, which can be alleviated by Atsttrin. Collectively, our data provide novel evidence of using PGRN derivatives as a promising therapeutic approach to improve the functional recovery for patients with spinal cord injury.
An 8Gb/s/pin 4pJ/b/pin Single-T-Line dual (base&#x002B;RF) band simultaneous bidirectional mobile memory I/O interface with inter-channel interference suppression (2012)

The demand for higher power efficiency and bandwidth is increasing as mobile devices keep enhancing its graphic computing and media processing capabilities. Current memory interfaces with single-wire signaling operate at 5Gb/s/pin [1] and 6Gb/s/pin [2] with the power efficiency of 17.4pJ/b/pin and 15.8pJ/b/pin, respectively. Mobile DDR memory I/O with differential signaling has better power efficiency of 6.4pJ/b/pin [3], and so does the prior dual-band interconnect (DBI) [4] with the efficiency of 5pJ/b/pin at 4.2Gb/s/pin for simultaneous bidirectional (SBD) mobile memory I/O interface. However, DBI's differential signaling is incompatible with existing standards, and it also occupies large die area for using differential transmission lines and an LC-oscillator for generating RF-carrier. To alleviate these concerns, we propose to use a Single-Transmission-Line DBI (STL-DBI) with the best figure-of-merit (FoM) defined as data rate per pin divided by the I/O-interface die area and power consumption.
Quick simulation: a review of importance sampling techniques in communications systems (1997)

Importance sampling (IS) is a simulation technique which aims to reduce the variance (or other cost function) of a given simulation estimator. In communication systems, this usually, but not always, means attempting to reduce the variance of the bit error rate (BER) estimator. By reducing the variance, IS estimators can achieve a given precision from shorter simulation runs; hence the term "quick simulation." The idea behind IS is that certain values of the input random variables in a simulation have more impact on the parameter being estimated than others. If these "important" values are emphasized by sampling more frequently, then the estimator variance can be reduced. Hence, the basic methodology in IS is to choose a distribution which encourages the important values. This use of a "biased" distribution will, of course, result in a biased estimator if applied directly in the simulation. However, there is a simple procedure whereby the simulation outputs are weighted to correct for the use of the biased distribution, and this ensures that the new IS estimator is unbiased. Hence, the "art" of designing quick simulations via IS is entirely dependent on the choice of biased distribution. Over the last 50 years, IS techniques have flourished, but it is only in the last decade that coherent design methods have emerged. The outcome of these developments is that at the expense of increasing technical content, modern techniques can offer substantial run-time saving for a very broad range of problems. We present a comprehensive history and survey of IS methods. In addition, we offer a guide to the strengths and weaknesses of the techniques, and hence indicate which techniques are suitable for various types of communications systems. We stress that simple approaches can still yield useful savings, and so the simulation practitioner as well as the technical researcher should consider IS as a possible simulation tool.
Chimeric Analysis of the Multicomponent Multidrug Efflux Transporters from Gram-Negative Bacteria (2002)

Many multidrug transporters from gram-negative bacteria belong to the resistance-nodulation-cell division (RND) superfamily of transporters. RND-type multidrug transporters have an extremely broad substrate specificity and protect bacterial cells from the actions of antibiotics on both sides of the cytoplasmic membrane. They usually function as three-component assemblies spanning the outer and cytoplasmic membranes and the periplasmic space of gram-negative bacteria. The structural determinants of RND transporters responsible for multidrug recognition and complex assembly remain unknown. We constructed chimeric RND transporters composed of N-terminal residues of AcrB and C-terminal residues of MexB, the major RND-type transporters from Escherichia coli and Pseudomonas aeruginosa, respectively. The assembly of complexes and multidrug efflux activities of chimeric transporters were determined by coexpression of hybrid genes either with AcrA, the periplasmic component of the AcrAB transporter from E. coli, or with MexA and OprM, the accessory proteins of the MexAB-OprM pump from P. aeruginosa. We found that the specificity of interaction with the corresponding periplasmic component is encoded in the T60-V612 region of transporters. Our results also suggest that the large periplasmic loops of RND-type transporters are involved in multidrug recognition and efflux.
Spectral Formation in Galactic X-ray Sources (1982)

The plasmid-borne pheBA operon of Pseudomonas putida strain PaW85 allows growth of the host cells on phenol. The promoter of this operon is activated by the chromosomally encoded LysR-type regulator CatR, in the presence of the inducer cis,cis-muconate. cis,cis-muconate is an intermediate of catechol degradation by the chromosomally encoded ortho or beta-ketoadipate pathway. The catBC operon encodes two enzymes of the beta-ketoadipate pathway and also requires CatR and cis,cis-muconate for its expression. The promoters of the pheBA and catBC operons are highly homologous, and since both respond to CatR, it is likely that the pheBA promoter was recruited from the ancestral catBC promoter. Gel shift assays and DNase I footprinting have shown that the pheBA promoter has a higher binding affinity for CatR than the catBC promoter. Like the catBC promoter, the pheBA promoter forms two complexes (C1 and C2) with CatR in the absence of cis,cis-muconate, but only forms a single complex (C2) in the presence of cis,cis-muconate. Like the catBC promoter CatR repression binding site (RBS) and activation binding site (ABS) arrangement, the pheBA promoter demonstrates the presence of a 26 bp segment highly homologous to the RBS that is protected by CatR from DNase I digestion in the absence of the inducer. An additional 16 bp sequence, similar to the catBC promoter ABS, is protected only when the inducer cis-cis-muconate is present. The binding of CatR in absence of cis,cis-muconate bends the catBC and pheBA promoter regions to significantly different degrees, but CatR binding in the presence of cis,cis-muconate results in a similar degree of DNA bending. The evolutionary implications of the interactions of CatR with these two promoters are discussed.
Application and Device Modeling of Liquid Crystal Displays (1985)

Abstract Many kinds of modes of liquid crystal display have been considered by using various types of liquid crystals, their surface alignments and optical effects. Among these modes, the twisted nematic mode (TN-mode) is most widely used, so that fundamental device modeling of this type display is discussed on surface treatments of substrates, and on design condition of material and device parameters. The next trend of development of the liquid crystal displays are increasing information contents, realization of multicolor or full-color display, increasing the display size and improvement of response speed. Their prospects and problems are also discussed.
Tracking human motion in structured environments using a distributed-camera system (1999)

This paper presents a comprehensive framework for tracking coarse human models from sequences of synchronized monocular grayscale images in multiple camera coordinates. It demonstrates the feasibility of an end-to-end person tracking system using a unique combination of motion analysis on 3D geometry in different camera coordinates and other existing techniques in motion detection, segmentation, and pattern recognition. The system starts with tracking from a single camera view. When the system predicts that the active camera will no longer have a good view of the subject of interest, tracking will be switched to another camera which provides a better view and requires the least switching to continue tracking. The nonrigidity of the human body is addressed by matching points of the middle line of the human image, spatially and temporally, using Bayesian classification schemes. Multivariate normal distributions are employed to model class-conditional densities of the features for tracking, such as location, intensity, and geometric features. Limited degrees of occlusion are tolerated within the system. Experimental results using a prototype system are presented and the performance of the algorithm is evaluated to demonstrate its feasibility for real time applications.
Relative Abundance of Oligosaccharides in <i>Candida</i> Species as Determined by Fluorophore-Assisted Carbohydrate Electrophoresis (2000)

Fluorophore-assisted carbohydrate electrophoresis (FACE) is a straightforward, sensitive method for determining the presence and relative abundance of individual oligomannosyl residues in Candida mannoprotein, the major antigenic determinant located on the outer surface of the yeast cell wall. The single terminal aldehydes of oligomannosyl residues released by hydrolysis were tagged with the charged fluorophore 8-aminonaphthalene-1,3,6-trisulfonate (ANTS) and separated with high resolution on the basis of size by polyacrylamide gel electrophoresis. ANTS fluorescence labeling was not biased by oligomannoside length; therefore, band fluorescence intensity was directly related to the relative abundance of individual oligomannoside moieties in heterogeneous samples. FACE analysis revealed the major oligomannosides released by acid hydrolysis and beta-elimination of Fehling-precipitated mannan from Candida albicans, which were the same as those previously reported in studies based on mass and nuclear magnetic spectroscopic analysis. FACE was also amenable to the analysis of samples obtained by direct hydrolysis of whole yeast cells. Whole-cell acid hydrolysis and whole-cell beta-elimination of two isolates each of C. albicans, C. glabrata, C. krusei, C. lusitaniae, C. parapsilosis, C. rugosa, C. stellatoidea, and C. tropicalis resulted in oligomannoside gel banding patterns that were species and strain specific for the 16 isolates surveyed. Whereas some bands were specific for an individual isolate or species, other bands were shared by two or three species in various groupings. Differences in the mannoprotein composition of C. albicans A9 and four spontaneous cell surface mutants were also detected. Mannan "fingerprints," or banding pattern profiles, derived from the electrophoretic mobilities of individual bands relative to the migration of acid-hydrolyzed dextran (relative migration index) yielded profiles characteristic of individual isolates not revealed by standard assimilation and biochemical profiles. FACE represents an accessible, sensitive, and quantitative analytical tool enabling the characterization of yeast mannan complexity.
Consistent normal interpolation (2010)

Rendering a polygonal surface with Phong normal interpolation allows shading to appear as it would for a true curved surface while maintaining the efficiency and simplicity of coarse polygonal geometry. However, this approximation fails in certain situations, especially for grazing viewing directions. Well-known problems include physically impossible reflections and implausible illumination. Some of these artifacts can be mitigated through special-case processing, although no universal or generally accepted approaches are available. In particular, all known solutions that guarantee that reflected rays will always point outward from the surface also create discontinuities in the reflection ray direction. We present a simple modification of Phong normal interpolation that allows physically plausible reflections and creates an appearance of a smooth surface. We introduce an additional scalar parameter that characterizes the deviation between per-vertex normals and per face normals and use it to adjust linearly interpolated normals. The proposed technique eliminates perceptually objectionable artifacts caused by inconsistencies between the shading and geometric normals while retaining most of the practical advantages and simplicity of the original Phong formulation.
Compiler testing via a theory of sound optimisations in the C11/C++11 memory model (2013)

Compilers sometimes generate correct sequential code but break the concurrency memory model of the programming language: these subtle compiler bugs are observable only when the miscompiled functions interact with concurrent contexts, making them particularly hard to detect. In this work we design a strategy to reduce the hard problem of hunting concurrency compiler bugs to differential testing of sequential code and build a tool that puts this strategy to work. Our first contribution is a theory of sound optimisations in the C11/C++11 memory model, covering most of the optimisations we have observed in real compilers and validating the claim that common compiler optimisations are sound in the C11/C++11 memory model. Our second contribution is to show how, building on this theory, concurrency compiler bugs can be identified by comparing the memory trace of compiled code against a reference memory trace for the source code. Our tool identified several mistaken write introductions and other unexpected behaviours in the latest release of the gcc compiler.
Apparent Activation Energy in High Frequency Microwave Sintering of Alumina Ceramic (2015)

The observed enhancements in the high frequency microwave processing alumina compared to those in conventional method at the same sintering temperatures have been studied. Some possible mechanisms responsible for the enhancements were investigated and are discussed in this paper. The enhancements could be associated with the increase either in driving force or in apparent activation energy of diffusion. An experiment to estimate the driving force of sintering is not easy to perform because the force depends not only on the density and grain size but also on the electric field in the materials. Therefore, a series of experiments to estimate the apparent activation energy were performed in high frequencies microwave and in conventional sintering method, as well. It was observed that the apparent activation energy in conventional sintering was much lower than that of microwave sintering. These activation energy values suggested that diffusion rate in microwaves sintering was faster, which led to the higher densification.