gebhart/patrepeval huggingface dataset:
Protein expression patterns in primary carcinoma of the vagina (2004)

Protein patterns in six samples from primary vaginal cancers, in five from normal vaginal tissue and in five primary cervical cancers, were analysed using two-dimensional polyacrylamide gel electrophoresis (2-DE). Protein expression profile was evaluated by computer-assisted image analysis (PDQUEST) and proteins were subsequently identified using matrix-assisted laser desorption/ionisation mass spectrometry. The aim was to analyse the protein expression profiles using the hierarchical clustering method in vaginal carcinoma and to compare them with the protein pattern in cervical carcinoma in order to find a helpful tool for correct classification and for increased biomedical knowledge. Protein expression data of a distinct set of 33 protein spots were differentially expressed. These differences were statistically significant (Mann-Whitney signed-Ranked Test, P<0.05) between normal tissue, vaginal and cervical cancer. Furthermore, protein profiles of pairs of primary vaginal and cervical cancers were found to be very similar. Some of the protein spots that have so far been identified include Tropomyosin 1, cytokeratin 5, 15 and 17, Apolipoprotein A1, Annexin V, Glutathione-S-transferase. Others are the stress-related proteins, calreticulin, HSP 27 and HSP 70. We conclude that cluster analysis of proteomics data allows accurate discrimination between normal vaginal mucosa, primary vaginal and primary cervical cancer. However, vaginal and cervical carcinomas also appear to be relatively homogeneous in their gene expression, indicating similar carcinogenic pathways. There might, further, be a possibility to identify tumour-specific markers among the proteins that are differentially expressed. The results from this study have to be confirmed by more comprehensive studies in the future.
Adhesion molecule expression in human melanocytic lesions (1993)

Martini, L.; Moretti, S.; Pinzi, C.; Cecca, E.; Giannotti, B.; Berti, E. Author Information
[Development of anticancer-agent-releasing microcapsules for chemotherapy combined with embolo-hyperthermic therapy]. (1995)

For the purpose of combining chemotherapy with embolo-hyperthermic therapy, we have developed microcapsules made of ferro-magnetic amorphous metal flakes that are additionally capable of releasing anticancer agents. The capsules can be used in a suspension to infuse them into a tumor with transcatheter arterial embolization (TAE). The capsules generate heat in an alternating magnetic field (185 kHz), which avoids heat generation by the body itself. At a certain intensity of the magnetic field, the maximum temperature of the capsule is determined by the Curie point of the amorphous metal. After reaching the maximum temperature, the capsule maintains the temperature by itself within an accuracy of +/- 0.5 degree C. In animal experiments, the capsules generated sufficient heat for interstitial hyperthermia. The tissue concentration of the anticancer agent after TAE with the capsules is maintained at 10 to 20 times higher than that after intraarterial infusion of the anticancer agent solution. These results suggest the usefulness of this method for embolo-hyperthermic therapy combined with intensive chemotherapy without invasive temperature measurement.
Predictive switched diversity for slow speed mobile terminals (2002)

Multipath fading is a difficult problem in many mobile communication applications. Especially, in the applications characterized by low terminal speeds like wireless local loop (WLL) and pedestrian communications the terminal can be in a deep fade for long periods of time. Consequently, the performance of the radio link is seriously degraded. Many techniques having their inherent advantages and disadvantages are available for combatting the multipath fading. One of the most straight-forward methods is antenna diversity. However, in addition to requiring more than one antenna a switching or combination circuitry is needed. The switched antenna diversity is simpler and cheaper solution compared to selecting or combining antenna diversity constructions since only one receiver circuitry is required. Consequently, it is an attractive choice for realizing mobile terminal antenna diversity. Unfortunately, the performance of the switched antenna diversity is worse than selecting and combining methods. A predictive switch-and-examine switching algorithm is presented. In addition, the performance of the developed method is compared to selection and maximal-ratio combining diversity methods by simulations in WLL and GSM/DCS typical urban (TU) channel. According to the results, the developed switching algorithm performed almost as well as selection diversity. Consequently, the predictive switched diversity is an attractive choice for mobile and fixed terminals.
Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase‐A isozyme (1985)

Eight cDNA clones for lactate dehydrogenase-A isozyme (LDH-A) were isolated from a human fibroblast cDNA library, characterized, and no sequence heterogeneity was found. Four cDNA clones appear to contain nearly full-length cDNA inserts and the complete nucleotide sequence of 1710 base pairs consists of the protein-coding sequence (999 base pairs), the 5' (97 base pairs) and 3' (565 base pairs) untranslated regions and poly(dA) tail (49 base pairs). The predicted amino acid sequence of the human LDH-A polypeptide shows 92% homology (27 differences out of 331 amino acids compared) with that of the pig LDH-A subunit determined by direct protein sequencing [Kiltz et al. (1977) Hoppe-Seyler's Z. Physiol. Chem. 358, 123-127]. Human genomic clones containing an LDH-A pseudogene were isolated and the nucleotide sequence of 1635 base pairs from an intronless pseudogene was determined. The presence of two termination codons, two deletions of three nucleotides each and the replacement of three arginine residues at the active site (nos 98, 105 and 168) by other amino acids renders its coding region incapable of producing a functional LDH-A protein. A comparison between human LDH-A cDNA and the pseudogene sequences reveals 12.9% differences (114 transitions, 65 transversions and 36 deletions/insertions). Further, only four out of the 25 dCpdG dinucleotides present in the cDNA sequence remain unchanged, although the sequences possess 87.1% homology.
PDX:PBX complexes are required for normal proliferation of pancreatic cells during development (2001)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Optimization for illumination systems: the next level of design (2004)

Computers are routinely used to design illumination systems. Automating the design process is enhanced through the use of optimization procedures. This paper describes some of the underlying illumination optimization fundamentals: parameterization, merit functions, and optimization algorithms. Numerous interesting examples of illumination design problems that benefit from optimization are shown. These examples illustrate illumination optimization through use of ray aiming, computing illuminance using flux tubes, and computing illuminance using Monte Carlo simulations.
Surface modification of talc particles by dry coating : influence on the wettability and the dispersibility in aqueous solutions (2009)

International audience
Blind Transmitter IQ Imbalance Compensation in M-QAM Optical Coherent Systems (2017)

We investigate transmitter IQ imbalance compensation based on the blind adaptive source separation (BASS) method in a dual-polarization M-QAM optical coherent system. The robustness of the BASS method against the residual carrier frequency offset (CFO) is numerically investigated and compared to that of the Gram–Schmidt orthogonalization procedure (GSOP). We further validate experimentally the proposed method with 10 Gbaud optical 4-QAM and 16-QAM signals at 30° and 10° phase imbalance, respectively, with simulated impairments. More specifically, in the presence of 5×10−6 residual CFO (normalized to the sample rate), the optical signal-to-noise ratio penalty reduction of the BASS method compared to the GSOP method is 1 dB for 4-QAM at a bit error ratio (BER) of 2×10−3 and 2 dB for 16-QAM at a BER of 10−3. In contrast to the GSOP, which requires an independent block, the BASS method can be integrated into an equalizer, simplifying the operation and allowing parallel implementation.
Peregrine (2019)

Database administrators (DBAs) were traditionally responsible for optimizing the on-premise database workloads. However, with the rise of cloud data services, where cloud providers offer fully managed data processing capabilities, the role of a DBA is completely missing. At the same time, optimizing query workloads is becoming increasingly important for reducing the total costs of operation and making data processing economically viable in the cloud. This paper revisits workload optimization in the context of these emerging cloud-based data services. We observe that the missing DBA in these newer data services has affected both the end users and the system developers: users have workload optimization as a major pain point while the system developers are now tasked with supporting a large base of cloud users.
3D modeling system of human face and full 3D facial caricaturing (2002)

This paper proposes a method for modeling 3D face from the 3D facial images captured from the surrounding 2D cameras by which the color texture and surface shape information of the face are synchronously measured. And 3D facial caricature is proposed by applying 2.5D PICASSO system to the proposed surrounding 3D face model. Automatic method for extracting regions of the facial parts is technically maintained and the composition strategies for integrating a few 2.5D facial caricatures into surrounding 3D caricature are also proposed.
Nivel de adaptación y afrontamiento en los pacientes con Accidente Cerebro Vascular, tras valorar las respuestas humanas aplicando el Modelo de Adaptación de Callista Roy (2013)

El Accidente Cerebrovascular (ACV) constituye una enfermedad paradigmatica en el estudio de la adaptacion humana ante las nuevas necesidades de salud que surgen como consecuencia de este evento. Por este motivo se considera oportuno desarrollar la aplicacion del Modelo de Adaptacion de Callista Roy en este tipo de pacientes desde la fase mas aguda, identificando las conductas y estimulos relacionados con sus respuestas adaptativas, contribuyendo a la planificacion de las intervenciones requeridas para manejar los estimulos, y asi lograr una adaptacion eficaz a su salud y entorno. El objetivo de este proyecto es analizar el nivel de afrontamiento y adaptacion de los pacientes diagnosticados de Accidente Cerebrovascular (ACV) en la fase aguda durante su estancia hospitalaria. El diseno del estudio es descriptivo transversal. Sera necesario incluir en este estudio una muestra de 156 pacientes (IC 95%, precision 0.05), que cumplan los criterios de inclusion y otorguen su consentimiento. La recogida de datos se efectuara mediante la version en espanol de la escala “Coping Adaptation Processing Scale” (CAPS) elaborada por Callista Roy, que aplicara la Enfermera del servicio de Medicina Interna del Hospital Sierrallana. Para el analisis estadistico se realizara una descripcion de todas las variables y se aplicara el test Chi-cuadrado. Palabras clave: - Accidente cerebro vascular. - Modelos de enfermeria. - Adaptacion.  Stroke is considered a paradigm illness in the study of human adaptation to the new health needs which arise as a result of this event. Because of this, it is considered appropriate to develop the implementation of Callista Roy's Adaptation Model in this kind of patients from the acute phase, in order to: identify behaviours and stimulus related to their adaptive responses, contribute the planning of the required interventions in order to handle stimulus, and thus to achieve an efficient adaptation to their health and environment. The aim of this project is to analyze the levels of coping strategies and adaptation of patients diagnosed with stroke in the acute phase during their hospital stays. It is a cross-sectional descriptive study. It will be necessary to include in this study a sample of 156 patients (95%, precision 0.05), who meet the inclusion criteria and grant their consent. Data collection was carried out through the Spanish version of Coping Adaptation Processing Scale (CAPS) developed by Callista Roy. Nurses who work in Internal Medicine service of Sierrallana Hospital will be who fill in the form. The statistical analysis will be a description of all variables and the Chi-square test. Keywords: - Stroke - Models, nursing. - Adaptation.
Synthesis and Characterization of Supported Cobalt–Manganese Nanoparticles as Model Catalysts for Fischer–Tropsch Synthesis (2014)

Abstract Supported Co is an effective catalyst for the Fischer–Tropsch synthesis of various hydrocarbon products that can be converted to diesel. Recent studies have shown that the formation of methane can be suppressed and the formation of C 5+ products enhanced by promoting Co with Mn. Because the activity and product selectivity of Co‐based catalysts are dependent on the size of Co nanoparticles and the extent of Co promotion by Mn, it is desirable to understand these effects by investigating the performance of Co nanoparticles with well‐defined size and elemental composition. The present study was undertaken with the aim of producing well‐defined nanoparticles of Co and Co–Mn and then supporting them on silica. Co and Co–Mn particles were synthesized through the polyol reduction of Co and Mn acetylacetonates. By controlling synthesis conditions, Co particles with diameters of 7–10 nm and similarly sized Co–Mn (Mn/Co=0.1) particles were prepared. XRD and elemental mapping with scanning TEM‐energy‐dispersive X‐ray spectroscopy and scanning TEM‐electron energy loss spectroscopy studies suggested that most of the Mn species was associated with the Co particles. Ex situ prepared Co and Co–Mn nanoparticles were first supported on silica and then investigated for the catalytic activity for the Fischer–Tropsch synthesis. The turnover frequencies and product distributions obtained with silica‐supported Co and Co–Mn nanoparticles were similar to those obtained with catalysts prepared by using the conventional incipient wetness impregnation method. However, the rate of CO consumption per mass of Co was much lower for the catalysts produced by supporting ex situ prepared nanoparticles. This effect was attributed to the sintering of the nanoparticles during their calcination and reduction. Magnetic interactions among nanoparticles during their immobilization and thermal pretreatment were identified as the primary cause of sintering.
In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir (2013)

NCT00869661, NCT01057667.
Thermal Analysis of Zone‐Melting Recrystallization of Silicon‐on‐Insulator Structures with an Infrared Heat Source: An Overview (1992)

Thermal processing of semiconductive multilayer thin film structures is used extensively for material quality enhancement. The quality of the resultant material is highly dependent on the heat transfer dynamics of the process. Although trial and error techniques are still used for process parameter optimization, efforts have been made tounderstand the fundamental heat transfer mechanisms involved. This paper presents an verview of studies on thermal issues that affect the material quality of multilayer thin film structures during processing with an infrared heat source. Emphasis is placed on investigations of zone-melting recrystallization of silicon-on-insulator structures using a graphite strip as a heat source. Studies on the conduction, macroscale and microscale radiation, processing chamber convection, scan speed, and constitutional supercooling are reviewed. Analyses of thermally driven instabilities at the solid-liquid interface are reported. Areas where further research is needed are also identified. © 1991, The Electrochemical Society, Inc. All rights reserved.
Multi-layer electroluminescence camera: a concept and Monte Carlo study (2002)

A concept for a multi-layer electroluminescence camera (MELC) for low energy gamma-ray imaging is presented. The MELC contains a multiple layer electrode structure immersed in a pressurized noble gas. The electrodes are made of thin foils covered by arrays of wave-shifting fibers optically coupled to outside photodetectors. The MELC is designed to achieve sub-mm 3D position resolution with an energy resolution about 1-2% at 140 keV. The number of readout channels is about 300 per layer per square meter of the imaging field. Total detection efficiency depends on the number of layers and gas pressure and can be comparable to that of solid state detectors. The count rate can be up to 10 MHz per layer. Computer simulations, undertaken to study the feasibility, and potential applications of the MELC are described.
A Novel Coplanar Waveguide Feed Zeroth-Order Resonant Antenna With Resonant Ring (2014)

A novel structure of a coplanar waveguide (CPW)-fed antenna is presented. A method to extend the bandwidth of metamaterial (MTM) antennas based on composite right/left-handed transmission line (CRLH-TL) is proposed. A prototype of the proposed antenna has been constructed and experimentally studied. The measured return loss bandwidth (-10 dB) is enhanced from 240 MHz (1.63-1.87 GHz) to 840 MHz (1.67-2.51 GHz), which corresponds to the fractional bandwidth of 14.0% and 40.2%. Measured peak gain and measured radiation efficiency are up to 4.13 dB and 83.69% at the operating frequency of 2.09 GHz. Because of wide bandwidth, good radiation characteristics, and acceptable peak realized gains, the proposed antenna is very suitable for GSM/UMTS/LTE/WLAN wireless communication systems.
Extending On-chip Interconnects for rack-level remote resource access (2016)

The need to perform data analytics on exploding data volumes coupled with the rapidly changing workloads in cloud computing places great pressure on data-center servers. To improve hardware resource utilization across servers within a rack, we propose Direct Extension of On-chip Interconnects (DEOI), a high-performance and efficient architecture for remote resource access among server nodes. DEOI extends an SoC server node's on-chip interconnect to access resources in adjacent nodes with no protocol changes, allowing remote memory and network resources to be used as if they were local. Our results on a four-node FPGA prototype show that the latency of user-level, cross-node, random reads to DEOI-connected remote memory is as low as 1.16µs, which beats current commercial technologies. We exploit DEOI remote access to improve performance of the Redis in-memory key-value framework by 47%. When using DEOI to access remote network resources, we observe an 8.4% average performance degradation and only a 2.52µs ping-pong latency disparity compared to using local assets. These results suggest that DEOI can be a promising mechanism for increasing both performance and efficiency in next-generation data-center servers.
Non-ATG–initiated translation directed by microsatellite expansions (2010)

Trinucleotide expansions cause disease by both protein- and RNA-mediated mechanisms. Unexpectedly, we discovered that CAG expansion constructs express homopolymeric polyglutamine, polyalanine, and polyserine proteins in the absence of an ATG start codon. This repeat-associated non-ATG translation (RAN translation) occurs across long, hairpin-forming repeats in transfected cells or when expansion constructs are integrated into the genome in lentiviral-transduced cells and brains. Additionally, we show that RAN translation across human spinocerebellar ataxia type 8 (SCA8) and myotonic dystrophy type 1 (DM1) CAG expansion transcripts results in the accumulation of SCA8 polyalanine and DM1 polyglutamine expansion proteins in previously established SCA8 and DM1 mouse models and human tissue. These results have implications for understanding fundamental mechanisms of gene expression. Moreover, these toxic, unexpected, homopolymeric proteins now should be considered in pathogenic models of microsatellite disorders.
Novel thick-grating beam-squeezing device in Ta <sub>2</sub> O <sub>5</sub> corrugated planar waveguide (1984)

The fabrication and performance of a novel thick-grating beam-squeezing device in a Ta2O5 corrugated planar waveguide is described. The device, in which the design relies on consideration of the group velocities of the light inside the periodic guide at Bragg incidence, features a curved (hyperbolic) boundary transition between smooth and corrugated waveguide regions. A contraction ratio of about 30 is achieved.
Biological Applications of Rare-Earth Based Nanoparticles (2011)

Biomedicine and cell and molecular biology require powerful imaging techniques of the single molecule scale to the whole organism, either for fundamental science or diagnosis. These applications are however often limited by the optical properties of the available probes. Moreover, in cell biology, the measurement of the cell response with spatial and temporal resolution is a central instrumental problem. This has been one of the main motivations for the development of new probes and imaging techniques either for biomolecule labeling or detection of an intracellular signaling species. The weak photostability of genetically encoded probes or organic dyes has motivated the interest for different types of nanoparticles for imaging such as quantum dots, nanodiamonds, dye-doped silica particles, or metallic nanoparticles. One of the most active fields of research in the past decade has thus been the development of rare-earth based nanoparticles, whose optical properties and low cytotoxicity are promising for biological applications. Attractive properties of rare-earth based nanoparticles include high photostability, absence of blinking, extremely narrow emission lines, large Stokes shifts, long lifetimes that can be exploited for retarded detection schemes, and facile functionalization strategies. The use of specific ions in their compositions can be moreover exploited for oxidant detection or for implementing potent contrast agents for magnetic resonance imaging. In this review, we present these different applications of rare-earth nanoparticles for biomolecule detection and imaging in vitro, in living cells or in small animals. We highlight how chemical composition tuning and surface functionalization lead to specific properties, which can be used for different imaging modalities. We discuss their performances for imaging in comparison with other probes and to what extent they could constitute a central tool in the future of molecular and cell biology.