gebhart/patrepeval huggingface dataset:
On-line radioisotope detection for capillary electrophoresis (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn-line radioisotope detection for capillary electrophoresisStephen L. Pentoney, Richard N. Zare, and Jeff F. QuintCite this: Anal. Chem. 1989, 61, 15, 1642–1647Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://doi.org/10.1021/ac00190a011Request reuse permissionsArticle Views114Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (804 KB) Get e-Alertsclose Get e-Alerts
Fast channel switching for hybrid unicast/broadcast Mobile television (2008)

A new method for fast channel switching in a hybrid unicast/broadcast Mobile TV system is introduced. In case of a channel switch between broadcast channels, a channel switch frame is requested and delivered via a unicast connection. Using this technique, the waiting time for the next I-frame of the new channel is eliminated fastening the channel switching process.
Extended depth-of-focus microscopy via constrained deconvolution (2007)

We derive a method for extended depth-of-focus imaging, i.e., a method to render a 2-D image of a thick specimen, such that all the structures within the specimen appear in focus and with greatly increased contrast. We acquire a single image while moving the specimen through focus. The resulting image, which is severely blurred and has very low contrast, is then deconvolved. In the deconvolved image, the entire depth of the specimen is in focus. Because the image is collected continuously while the specimen moves through focus, the acquisition time is short. Likewise, because the deconvolution is done in 2-D, it is done very quickly even with an iterative algorithm.
Inside Cover: A Highly Active Catalyst for the Hydrogenation of Amides to Alcohols and Amines (Angew. Chem. Int. Ed. 44/2011) (2011)

A remarkably active catalyst system for the hydrogenation of a variety of acyclic and cyclic amides to the corresponding alcohols and amines is demonstrated by J. M. John and S. H. Bergens in their Communication on page 10 377 ff. Turnover numbers as high as 7200 are reported, as well as observations of the punitive active homogeneous catalyst, trans-[Ru(H)2(Ph2PCH2CH2NH2)2], derived from Ph2P(CH2)2NH2 and cis-[Ru(CH3CN)2(η3-C3H5)(cod)]BF4 (cod=1,5-cyclooctadiene).
Partially Fluorinated Aarylene Polyethers and their Ternary Blends with PBI and H<sub>3</sub>PO<sub>4</sub>. Part II. Characterisation and Fuel Cell Tests of the Ternary Membranes (2008)

Abstract Ternary blend membranes based on sulphonated partially fluorinated arylene polyether, polybenzimidazole (PBI) and phosphoric acid were prepared and characterised as electrolyte for high temperature proton exchange membrane fuel cells. Partially fluorinated arylene polyether was first prepared from polycondensation of decafluorobiphenyl with 2,2‐bis(4‐hydroxyphenyl)hexafluoropropane, followed by sulphonation with H 2 SO 4 /60% SO 3 , based on which binary blends with PBI were prepared and further doped with concentrated phosphoric acid at temperatures of up to 130 °C. Acid doping levels as high as 10–13 mol phosphoric acid per PBI repeat unit can be reached, showing small swelling and excellent mechanical strength. At an acid doping level of 11, a conductivity of 0.12 S cm –1 was obtained at 175 °C and 10% relative humidity. Such a membrane exhibits a tensile strength of 6 MPa, elongation of 220% and modulus of 50 MPa at 150 °C. Based on these ternary membranes large MEAs with an active area of 256 cm 2 have been prepared for a 2 kW el stack showing good performance and reproducibility.
Study on adsorption performance of 2,4,6-trichlorophenol from aqueous solution onto biochar derived from macroalgae as an efficient adsorbent (2020)

An efficient adsorbent was derived from Sargassum boveanum macroalgae (BCM) through a thermal pyrolysis process. It was characterized and investigated for the removal of 2,4,6–Trichlorophenol (TCP) from the aqueous solution. The effects of adsorbent mass, adsorbate concentration, and contact time were examined. The maximum removal efficiency and adsorption capacity were 100% and 175 mg g−1, respectively. The adsorption fitted Freundlich model and followed pseudo-second order kinetics. It was also found that the adsorption process was spontaneous, endothermic, and thermodynamically favorable. This study indicated that BCM adsorbent can remove 60% of TCP from the high saline seawater and it is reusable for three times.
S3BD: Secure Semantic Search over Encrypted Big Data in the Cloud (2018)

Cloud storage is a widely utilized service for both personal and enterprise demands. However, despite its advantages, many potential users with enormous amounts of sensitive data (big data) refrain from fully utilizing the cloud storage service due to valid concerns about data privacy. An established solution to the cloud data privacy problem is to perform encryption on the client-end. This approach, however, restricts data processing capabilities (eg, searching over the data). Accordingly, the research problem we investigate is how to enable real-time searching over the encrypted big data in the cloud. In particular, semantic search is of interest to clients dealing with big data. To address this problem, in this research, we develop a system (termed S3BD) for searching big data using cloud services without exposing any data to cloud providers. To keep real-time response on big data, S3BD proactively prunes the search space to a subset of the whole dataset. For that purpose, we propose a method to cluster the encrypted data. An abstract of each cluster is maintained on the client-end to navigate the search operation to appropriate clusters at the search time. Results of experiments, carried out on real-world big datasets, demonstrate that the search operation can be achieved in real-time and is significantly more efficient than other counterparts. In addition, a fully functional prototype of S3BD is made publicly available.
Use of dielectric loss to determine blend time for organic polymer solutions (1992)

Abstract When scaling up mixing applications, it is often important to measure blend time. In our application, we need to measure blend time in nonaqueous solutions of organic polymers in pilot‐ and plant‐scale steel tanks. Techniques employing visual observations can be used in small‐scale glass or Plexiglas tanks, but these methods are not applicable to large‐scale operations. Another standard technique is to measure conductivity of a tracer material, which is useful particularly for aqueous systems, but does not provide an adequate response for our system. A new technique that we established involves the measurement of the dielectric loss of a tracer material added to an acrylic polymer solution in mineral oil. It is demonstrated that the addition of N,N‐dimethylformamide (DMF) results in mixing curves that give blend times equivalent to those measured by visual methods. Our preliminary studies were performed in a 2‐L vessel over a temperature range of 30–120°C. The magnitude of the dielectric loss measurement is shown to depend on the scanning frequency of the measurement and the temperature of the polymer solution. The variation over a small temperature range is slight and will not interfere with the measurements.
Combinatorial logic based digital optical computing architectures (1988)

Most of the compute intensive SDI problem solving processors rely on a common set of algorithms found in numerical matrix algebra. Typically, all these problems are broken up into a set of linear equations where it is the processors task to solve this set. Algorithmic solutions range from the extensive use of the fast Fourier transform to the robust singular value decomposition method. Over the past several years considerable research has been focused on the use of arrays of computational processing elements, which, when configured correctly, will process these algorithms at extremely high speeds and with great algorithmic efficiency. To obtain these high speeds hardware development has progressed primarily in two areas: (1) semiconductor VLSI arrays utilizing 2-D planar semiconductor technology and (2) acoustooptic analog and digital arrays utilizing 3-D optical interconnect technology. This paper will focus on the formulation of 3-D optical interconnect methodology for numerical and general purpose binary combinatorial logic based optical computers.
Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents (1986)

A new class of heterocyclic compounds with potent antibacterial activity, namely, 2-substituted amino-3-fluoro-5,12-dihydro-5-oxobenzothiazolo[3, 2-a]quinoline-6-carboxylic acids, is described. The compounds are conformationally restricted analogues of 7-substituted amino-6-fluoro-1-aryl-1, 4-dihydro-4-oxoquinoline-3-carboxylic acids. Compounds 7 and 10, having a 4-methylpiperazinyl and a piperazinyl substitution at the 2-position, respectively, possess in vitro antibacterial activities comparable to norfloxacin (15). Compound 8, which has a 4-acetylpiperazinyl substitution at the 2-position, is active against Gram-positive organisms and nearly inactive against Gram-negative organisms. An efficient and short synthesis of this novel heterocyclic system via an intramolecular nucleophilic displacement cyclization reaction is reported.
Ghosting suppression for incremental principal component pursuit algorithms (2016)

In video background modeling, ghosting occurs when an object that belongs to the background is assigned to the foreground. In the context of Principal Component Pursuit, this usually occurs when a moving object occludes a high contrast background object, a moving object suddenly stops, or a stationary object suddenly starts moving. Based on a previously developed incremental PCP method, we propose a novel algorithm that uses two simultaneous background estimates based on observations over the previous n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> and n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> C n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) frames in order to identify and diminish the ghosting effect. Our computational results show that the proposed method greatly improves both the subjective quality and accuracy as determined by the F-measure.
A Mixed-Signal RF Pulse Width Modulator With High Time Resolution Utilizing Passive Delay Lines (2020)

We present a novel mixed-signal single-output outphasing RF Pulse Width Modulator (RF PWM) realized in 40nm CMOS. Two Digital-to-Time Converters (DTCs) synchronously phase shift an external LO according to two 9-bit outphasing input words. Coarse time quantization is provided by tapping the internal nodes of passive integrated LC delay lines. Finer resolution is added using switching capacitors of a Gm-C circuit attaining minimum time steps of 6ps/750fs respectively. “Hair-pin” inductors with minimized footprint have been employed for the silicon realization of each LC delay line. Measurement yields an ACLR of approx. -42 dBc from a 32 MHz BW multi-tone signal on a 2.65 GHz carrier.
Disjunctive Image Computation for Embedded Software Verification (2006)

Finite state models generated from software programs have unique characteristics that are not exploited by existing model checking algorithms. In this paper, we propose a novel disjunctive image computation algorithm and other simplifications based on these characteristics. Our algorithm divides an image computation into a disjunctive set of easier ones that can be performed in isolation. Hypergraph partitioning is used to minimize the number of live variables in each disjunctive component. We use the live variables to simplify transition relations and reachable state subsets. Our experiments on a set of real-world C programs show that the new algorithm achieves orders-of-magnitude performance improvement over the best known conjunctive image computation algorithm
Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA (2000)

Smad proteins are effector molecules that transmit signals from the receptors for the transforming growth factor β (TGF-β) superfamily to the nucleus; of the Smad proteins, Smad2 and Smad4 are essential components for mouse early embryogenesis. We demonstrated that Hgs, a FYVE domain protein, binds to Smad2 in its C-terminal half and cooperates with another FYVE domain protein, the Smad anchor for receptor activation (SARA), to stimulate activin receptor-mediated signaling through efficient recruitment of Smad2 to the receptor. Furthermore, a LacZ knock-in allele of the C-terminal half-deletion mutant of mouse Hgs was created by gene targeting. The introduced mutation causes an embryonic lethality between embryonic days 8.5 and 10.5. Mutant cells showed significantly decreased responses to stimulation with activin and TGF-β. These findings suggest that the two FYVE domain proteins, Hgs and SARA, are prerequisites for receptor-mediated activation of Smad2.
On fundamental quantum noises of whispering gallery mode electro-optic modulators (2007)

Using the example of whispering gallery mode (WGM) electro-optic modulator (EOM) we show that the majority of phase EOMs, particularly the resonant types, introduce additional quantum noise to the modulated light. The noise power grows quadratically with the optical power and results from the unavoidable spontaneous emission process originating from the strongly nondegenerate parametric interaction. This latter process is the physical basis for modulation.
Single platform passive Doppler geolocation with unknown emitter frequency (2010)

This paper describes a novel particle filter technique to geolocate radio frequency emitters with unknown emitter frequency using passive, Doppler-shifted frequency measurements. Doppler-based geolocation algorithms suffer in general, from the non-linear and coupled relationship between the unknown emitter location, unknown emitter frequency, and observed Doppler-shifted frequency measurements. This non-linearity precludes a computationally efficient, closed-form implementation and directs algorithmic solutions toward robust but inaccurate and computationally expensive grid-based techniques. The new method leverages the rapid particle convergence properties developed in the simultaneous location and mapping (SLAM) community with the robustness of grid-based solutions to define a new more effective importance density. The new method's performance is compared against a standard sampling importance resample (SIR) particle filtering implementation and the Cramer-Rao Lower Bound. Results indicate that the new approach can significantly improve the convergence rate with far fewer particles.
The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia (2019)

In β-thalassemia, accumulated free α-globin forms intracellular precipitates that impair erythroid cell maturation and viability. Protein quality control systems mitigate β-thalassemia pathophysiology by degrading toxic free α-globin, although the associated mechanisms are poorly understood. We show that loss of the autophagy-activating Unc-51-like kinase 1 (<i>Ulk1</i>) gene in β-thalassemic mice reduces autophagic clearance of α-globin in red blood cell precursors and exacerbates disease phenotypes, whereas inactivation of the canonical autophagy-related 5 (<i>Atg5</i>) gene has relatively minor effects. Systemic treatment with the mTORC1 inhibitor rapamycin reduces α-globin precipitates and lessens pathologies in β-thalassemic mice via an ULK1-dependent pathway. Similarly, rapamycin reduces free α-globin accumulation in erythroblasts derived from CD34<sup>+</sup> cells of β-thalassemic individuals. Our findings define a drug-regulatable pathway for ameliorating β-thalassemia.
Differential Detection for Nanoplasmonic Resonance Sensors (2011)

A differential measurement design employing two nearly collinear optical beams can lead to surface plasmon polariton (SPP) sensors of increased dynamic range and signal-to-noise ratio. We demonstrate a differential measurement device that is based on wavelength interrogation, employs a single incident polarization state, and is combined with a 2-D nanohole array for operation at near-normal incidence, where this approach offers a decrease in the measurement time.
Evaluation of advanced cooling therapy’s esophageal cooling device for core temperature control (2016)

Managing core temperature is critical to patient outcomes in a wide range of clinical scenarios. Previous devices designed to perform temperature management required a trade-off between invasiveness and temperature modulation efficiency. The Esophageal Cooling Device, made by Advanced Cooling Therapy (Chicago, IL), was developed to optimize warming and cooling efficiency through an easy and low risk procedure that leverages heat transfer through convection and conduction. Clinical data from cardiac arrest, fever, and critical burn patients indicate that the Esophageal Cooling Device performs very well both in terms of temperature modulation (cooling rates of approximately 1.3°C/hour, warming of up to 0.5°C/hour) and maintaining temperature stability (variation around goal temperature ± 0.3°C). Physicians have reported that device performance is comparable to the performance of intravascular temperature management techniques and superior to the performance of surface devices, while avoiding the downsides associated with both.
Forecasting seizure likelihood with wearable technology (2021)

Abstract The unpredictability of epileptic seizures exposes people with epilepsy to potential physical harm, restricts day-to-day activities, and impacts mental well-being. Accurate seizure forecasters would reduce the uncertainty associated with seizures but need to be feasible and accessible in the long-term. Wearable devices are perfect candidates to develop non-invasive, accessible forecasts but are yet to be investigated in long-term studies. We hypothesized that machine learning models could utilize heart rate as a biomarker for well-established cycles of seizures and epileptic activity, in addition to other wearable signals, to forecast high and low risk seizure periods. This feasibility study tracked participants’ (n = 11) heart rates, sleep, and step counts using wearable smartwatches and seizure occurrence using mobile seizure diaries for at least 6 months (mean = 14.6 months, SD = 3.8 months). Eligible participants had a diagnosis of refractory epilepsy and reported at least 20 seizures (mean = 135, SD = 123) during the recording period. An ensembled machine learning and neural network model estimated seizure risk either daily or hourly, with retraining occurring on a weekly basis as additional data was collected. Performance was evaluated retrospectively against a rate-matched random forecast using the area under the receiver operating curve. A pseudo-prospective evaluation was also conducted on a held-out dataset. Of the 11 participants, seizures were predicted above chance in all (100%) participants using an hourly forecast and in ten (91%) participants using a daily forecast. The average time spent in high risk (prediction time) before a seizure occurred was 37 minutes in the hourly forecast and 3 days in the daily forecast. Cyclic features added the most predictive value to the forecasts, particularly circadian and multiday heart rate cycles. Wearable devices can be used to produce patient-specific seizure forecasts, particularly when biomarkers of seizure and epileptic activity cycles are utilized.
Versatile Small-Molecule Motifs for Self-Assembly in Water and the Formation of Biofunctional Supramolecular Hydrogels (2010)

This feature article introduces new structural motifs (referred as "samogen") that serve as the building blocks of hydrogelators for molecular self-assembly in water to result in a series of supramolecular hydrogels. Using a compound that consists of two phenylalanine residues and a naphthyl group (also abbreviated as NapFF (1) in this text) as an example of the samogens, we demonstrated the ability of the samogens to convert bioactive molecules into molecular hydrogelators that self-assemble in water to result in nanofibers. By briefly summarizing the properties and applications (e.g., wound healing, drug delivery, controlling cell fate, typing bacteria, and catalysis) of these molecular hydrogelators derived from the samogens, we intend to illustrate the basic requirements and promises of the small-molecule hydrogelators for applications in chemistry, materials science, and biomedicine.
Lens Epithelium-derived Growth Factor Relieves Transforming Growth Factor-β1-induced Transcription Repression of Heat Shock Proteins in Human Lens Epithelial Cells (2003)

Lens epithelium-cell derived growth factor (LEDGF) is a transcriptional activator. It protects the cells by binding to cis-stress response ((A/T)GGGG(T/A)), and heat shock (HSE; nGAAn) elements in the stress genes and activating their transcription. Transforming growth factor-beta (TGF-beta) has been implicated in the control of tissue homeostasis, terminal differentiation, and apoptosis. Here we provide evidence that TGF-beta1 down-regulates LEDGF expression and diminishes its affinity for DNA during TGF-beta1-induced phenotypic changes and apoptosis in human lens epithelial cells. Surprisingly, TGF-beta1 treatment for 48 h markedly decreased the LEDGF, Hsp27, and alphaB-crystallin promoter activities with the decrease of abundance of LEDGF mRNA and protein. Deletion mutants of the LEDGF promoter showed that one TGF-beta1 inhibitory element (TIE) like sequence nnnTTGGnnn (-444 to -433) contributed to this negative regulation. Mutation of TIE (TTGG to TATT) abolished the down-regulation of the LEDGF promoter. Gel mobility and supershift assays showed that LEDGF in the nuclear extracts of TGF-beta1-treated human lens epithelial cells did not bind to stress-response elements and HSE. The TGF-beta1-induced down-regulation of LEDGF, Hsp27, and alphaB-crystallin promoters activity was reversed by cotransfection with a plasmid expressing LEDGF. Because overexpression of LEDGF was able to relieve TGF-beta1 and/or stress-induced changes, it would be a candidate molecule to postpone age-related degenerating disorders.
A combined digital-holographic microscope and light-field- fluorescence microscope for extant life searches (2020)

Searches for microbial life in our solar system’s Ocean Worlds can be carried out with volumetric microscopy techniques. A prototype microscope combining a digital holographic microscope with a light-field fluorescence microscope has been demonstrated.