gebhart/patrepeval huggingface dataset:
The assessment of fatigue-related changes in stride mechanics, variability and long-range correlations in recreational and elite distance runners using foot-mounted inertial sensors (2017)

A Thesis Submitted to the Faculty of Graduate Studies and Research In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Kinesiology and Health Studies, University of Regina. xiv, 190 p.
A New, Yet Familiar, Lamellar Zeolite (2010)

Compulsive layers: Lamellar zeolites are crystalline layered materials with porosity within the layers. A recent breakthrough regarding the synthesis of a new lamellar zeolite with the well-known ZSM-5 structure is highlighted in light of previous work on lamellar zeolites and the emerging applications of hierarchical zeolites and zeolitic layers, which include heterogeneous catalysis and zeolite membranes.
Understanding the Effects of Printed Health Education Materials: Which Features Lead to Which Outcomes? (2001)

Printed health education materials (HEMs) are widely used to increase awareness and knowledge, change attitudes and beliefs, and help individuals adopt and maintain healthy lifestyle behaviors. While much of the contemporary research and development of persuasive communication is based on McGuire's input/output model, to date few studies have compared the impact of a large set of inputs across a comprehensive set of the 12 outputs. We examined the effects of printed HEMs on weight loss on the cognitive, affective, and behavioral responses of 198 overweight adults. Participants were recruited via a newspaper advertisement and were randomly assigned to review one of three HEMs. Participants were interviewed and asked to complete a series of questionnaires both before and after viewing the HEMs. Regression analyses were conducted to identify the input characteristics associated with success at each of the output steps. The results revealed attractiveness, encouragement, level of information, and application to one's life were significantly associated with early steps (attention, liking, and understanding) as well as some of the mediating steps (recalling, keeping, and rereading HEMs). Later steps, such as intention to change behavior and show others, were associated with readiness to change, self-efficacy, and perceived application to one's life. Behavior change was more likely for those who received tailored materials and those who had higher self-efficacy. These results provide useful direction for the use of computers in tailoring the content of HEMs and the development of effective communication of health information on weight loss.
Cloning, expression, purification and characterisation of Erwinia carotovora L-asparaginase in Escherichia coli (2014)

The results of the present work form the basis for a new engineered form of ErA for future therapeutic use, which could be extended with crystallographic studies.
The metastasis-associated gene MTA1 is upregulated in advanced ovarian cancer, represses ERβ, and enhances expression of oncogenic cytokine GRO (2008)

The metastasis-associated genes MTA1 and MTA3 are transcriptional repressors with potential effects on cancer. We analyzed the expression of MTA1, MTA3, ERalpha, ERbeta and E-cadherin in a total of 115 paraffin-embedded ovarian cancer tissues with respect to cancer staging and FIGO grading. Expression of MTA1, but not that of MTA3, was found to be significantly enhanced in ovarian cancer tissues with advanced cancer stages and higher FIGO grading, indicating an important role of MTA1 in the progression of ovarian cancer. To get further insights into the function of MTA1 in ovarian cancer, MTA1-overexpressing cancer cell clones were generated. In vitro, overexpression of exogenous MTA1 in OVCAR-3 cells had no effect on cell proliferation but enhanced the ability of anchorage-independent growth in soft agar colony formation assays. MTA1 overexpression resulted in downregulation of E-cadherin and MTA3 expression and enhanced expression of the transcriptional repressors SNAIL and SLUG. MTA1 further reduced ERbeta expression in vitro and inversely correlated with ERbeta expression in vivo. Screening for the expression of angiogenic cytokines expressed by ovarian cancer cells revealed MTA1-mediated upregulation of the oncogenic and angiogenic cytokine GRO (growth-regulated oncogene, CXCL1). Thus, in ovarian cancer, MTA1 expression directly and indirectly regulates the expression of several cancer-promoting as well as metastasis-facilitating factors, indicating an important role for MTA1 expression during ovarian cancer progression.
Expert Systems in Library and Information Science (2005)

Expert Systems have evolved as one of the most successful branch of Artificial Intelligence during last two decades. The fifth generation computers developed a potential for natural language processing and reasoning capabilities in a much better way than their precursors. Areas in man - machine interfaces developed into knowledge based expert systems. The present paper gives a short overview and a background of Expert Systems, their features, components involved, and applications in Library and Information Science. It brings out the future challenges which are likely to be faced by information professional with the intelligent use of Expert Systems.
Regulation of the Apaf-1–caspase-9 apoptosome (2010)

Apoptosis is probably not the only form of cell death, but it is currently the only form for which the proteins that constitute the death pathway have been characterized at the structural, biochemical and genetic levels in great detail. Apoptosis is an ancient paradigm, going back to the earliest
Improvements in intrinsic feature pose measurement for awake animal imaging (2010)

Development has continued with intrinsic feature optical motion tracking for awake animal imaging to measure 3D position and orientation (pose) for motion compensated reconstruction. Prior imaging results have been directed towards head motion measurement for SPECT brain studies in awake unrestrained mice. This work improves on those results in extracting and tracking intrinsic features from multiple camera images and computing pose changes from the tracked features over time. Previously, most motion tracking for 3D imaging has been limited to measuring extrinsic features such as retro-reflective markers applied to an animal's head. While this approach has been proven to be accurate, the use of external markers is undesirable for several reasons. The intrinsic feature approach has been further developed from previous work to provide full pose measurements for a live mouse scan. Surface feature extraction, matching, and pose change calculation with point tracking and accuracy results are described. Experimental pose calculation and 3D reconstruction results from live images are presented.
Promoting Articular Cartilage Repair (2002)

For more than 250 years, physicians and scientists have been seeking ways to repair or regenerate synovial-joint articular surfaces following articular-cartilage loss or degeneration (1–3). (Repair refers to restoring a damaged articular surface with new tissue that resembles but does not duplicate the structure, composition, and function of articular cartilage; regeneration refers to forming new tissue indistinguishable from normal articular cartilage [4–6].) They made little progress for the majority of these 250 years, but in the last three decades clinical and basic scientific investigations have shown that implantation of artificial matrices, growth factors, perichondrium, periosteum and transplanted chondrocytes, and mesenchymal stem cells can stimulate formation of cartilaginous tissue in synovial-joint osteochondral defects (6–10). Other work has demonstrated that joint loading and motion can influence articular cartilage and joint healing (11–13) , and that mechanical-loading influences the repair process in all of the tissues that form parts of synovial joints (5,14,15). In addition, review of several operative procedures used to treat osteoarthrosis (OA), including osteotomies, penetration of subchondral bone, and joint distraction and motion, has shown that these procedures can stimulate formation of new articular surfaces (9).The apparent potential of these multiple methods for stimulating formation of cartilaginous-articular surfaces has created great interest on the part of patients, physicians, and scientists, however the wide variety of methods and approaches to assessing their results have made it difficult to evaluate their success in restoring joint function and to define their most appropriate current clinical applications.
Method for producing nanoparticles and the nanoparticles produced therefrom (2023)

Disclosed herein is a method comprising disposing a container containing a metal and/or ferromagnetic solid and abrasive particles in a static magnetic field; where the container is surrounded by an induction coil; activating the induction coil with an electrical current, to heat up the metallic or ferromagnetic solid to form a fluid; generating sonic energy to produce acoustic cavitation and abrasion between the abrasive particles and the container; and producing nanoparticles that comprise elements from the container, the metal and/or the ferromagnetic solid and the abrasive particles. Disclosed herein too is a composition comprising first metal or a first ceramic; and particles comprising carbides and/or nitrides dispersed therein. Disclosed herein too is a composition comprising nanoparticles comprising chromium carbide, iron carbide, nickel carbide, y.-Fe and magnesium nitride.
Campylobacter infections: the emerging national pattern. (1987)

In the United States, 8,837 Campylobacter isolates and eight outbreaks of Campylobacter infections were reported in 1984, a national isolation rate of 4.9/100,000. C. jejuni represented 99 per cent of reported isolates. Age-specific incidence was highest among infants (11/100,000), and young adults (8/100,000); infants in the second month of life were at highest risk. An unexplained nationwide November peak, not observed in previous years, occurred in all age groups and suggests there is an homogeneous nationwide source for this infection.
Preliminary study about sublingual administration of bacteria-expressed pandemic H1N1 influenza vaccine in miniature pigs (2014)

Sublingual (SL) administration of influenza vaccine would be non-invasive and effective way to give human populations protective immunity against the virus, especially when pandemic influenza outbreaks. In this study, the efficacy of pandemic influenza virus-based subunit vaccines was tested after sublingual (SL) adjuvant administration in pigs. Eight specific pathogen-free Yucatan pigs were divided into 4 groups: nonvaccinated but challenged (A) and vaccinated and challenged (B, C, and D). The vaccinated groups were subdivided by vaccine type and inoculation route: SL subunit vaccine (hemagglutinin antigen 1 [HA1] + wild-type cholera toxin [wtCT], B); IM subunit vaccine (HA1 + aluminum hydroxide, C); and IM inactivated vaccine (+ aluminum hydroxide, D). The vaccines were administered twice at a 2-week interval. All pigs were challenged with pandemic influenza virus (A/swine/GCVP-KS01/2009 [H1N1]) and monitored for clinical signs, serology, viral shedding, and histopathology. After vaccination, hemagglutination inhibition titre was higher in group D (320) than in the other vaccinated groups (40-80) at the time of challenge. The mobility and feed intake were reduced in group C. Both viral shedding and histopathological lesions were reduced in groups B and D. Although this study has limitation due to the limited number of pigs (2 pigs per a group), the preliminary data in this study provided the protective potential of SL administration of bacteria-expressed pandemic H1N1 influenza vaccine in pigs. There should be additional animal studies about effective adjuvant system and vaccine types for the use of SL influenza vaccination.
First Sunday After Epiphany (1985)

Sermons for the First Sunday after Epiphany, including The Loss of God (1830), The Life of the World After the Example of the Many (1852), Back Sliders (1856), Progress in Virtue (1857), The Will to Save Our Souls (1857), and The Observance of the Law (1858). Apart of the Sermons series.
Enhancement of etoposide and methotrexate sensitivity by indomethacin in vitro. (1991)

The possibility of increasing the activity of etoposide (VP-16) by combining this anti-cancer agent with indomethacin (Indo) was investigated by treating murine and human cultured tumor cells with a combination of Indo and VP-16 and quantitating VP-16 cytotoxicity by the [3H]thymidine incorporation assay. Non-toxic concentrations of Indo were found to enhance the sensitivity to VP-16 in cultured Lewis lung carcinoma (LLC), YAC-1, P815, CCRF-CEM and K562 cells which were all relatively sensitive to VP-16. With the LLC, the Indo effect was dose dependent and near maximal at an Indo concentration of 0.5 micrograms/ml. Indo also increased the response of LLC cells to methotrexate, but not to bleomycin. Ibuprofen was less effective than Indo in enhancing VP-16 sensitivity in LLC cells. The enhanced sensitivity of VP-16 by Indo was not reversed by the prostaglandins PGE2 and PGD2, the analogs carbocyclic thromboxane A2 and carba-prostacyclin or conditioned medium removed after 24 h or 48 h of culture from near confluent LLC cell monolayers. This finding suggests that Indo is not augmenting VP-16 cytotoxicity by inhibiting cyclo-oxygenase activity and prostaglandin production. The lipoxygenase inhibitor, eicosatetraynoic acid (ETYA), was also ineffective in reversing the Indo augmentation of VP-16 sensitivity. This finding indicates that Indo is not acting by inhibiting cyclo-oxygenase and converting larger amounts of arachidonic acid to lipoxygenase products, such as leukotrienes, that could then interact with VP-16 to increase its sensitivity. In other studies, Indo was found to significantly increase the steady state accumulation of [3H]-VP-16 in all five cell lines studied. With the LLC cells, this increased steady state was achieved within 15 min after the addition of Indo to these cells and this enhanced VP-16 uptake was not reversed by the addition of prostaglandin E2 or prostaglandin D2. Thus, taken together, these studies indicate that Indo most likely enhances the cytotoxicity of VP-16 by increasing the cellular accumulation of VP-16. This newly identified function of Indo may be of potential clinical significance in the treatment of cancers in man.
SIMULATION OF PIANO SUSTAIN-PEDAL EFFECT BY PARALLEL SECOND-ORDER FILTERS (2008)

This paper presents a sustain-pedal effect simulation algorithm for piano synthesis, by using parallel second-order filters. A robust two-step filter design procedure, based on frequency-zooming ARMA modeling and least squares fit, is applied to calibrate the algorithm from impulse responses of the soundboard and the string register. The model takes into account the differences in coupling between the various strings. The algorithm can be applied to both sample-based and physics-based piano synthesizers. 1.
A model to estimate intrinsic document relevance from the clickthrough logs of a web search engine (2010)

We propose a new model to interpret the clickthrough logs of a web search engine. This model is based on explicit assumptions on the user behavior. In particular, we draw conclusions on a document relevance by observing the user behavior after he examined the document and not based on whether a user clicks or not a document url. This results in a model based on intrinsic relevance, as opposed to perceived relevance. We use the model to predict document relevance and then use this as feature for a "Learning to Rank" machine learning algorithm. Comparing the ranking functions obtained by training the algorithm with and without the new feature we observe surprisingly good results. This is particularly notable given that the baseline we use is the heavily optimized ranking function of a leading commercial search engine. A deeper analysis shows that the new feature is particularly helpful for non navigational queries and queries with a large abandonment rate or a large average number of queries per session. This is important because these types of query is considered to be the most difficult to solve.
Cavitation Bubble Dynamics inside Liquid Drops in Microgravity (2006)

We studied spark-generated cavitation bubbles inside water drops produced in microgravity. High-speed visualizations disclosed unique effects of the spherical and nearly isolated liquid volume. In particular, (1) toroidally collapsing bubbles generate two liquid jets escaping from the drop, and the "splash jet" discloses a remarkable broadening. (2) Shock waves induce a strong form of secondary cavitation due to the particular shock wave confinement. This feature offers a novel way to estimate integral shock wave energies in isolated volumes. (3) Bubble lifetimes in drops are shorter than in extended volumes in remarkable agreement with herein derived corrective terms for the Rayleigh-Plesset equation.
Laser Interference Lithography (2011)

In this chapter we explain how submicron gratings can be prepared by Laser Interference Lithography (LIL). In this maskless lithography technique, the standing wave pattern that exists at the intersection of two coherent laser beams is used to expose a photosensitive layer. We show how to build the basic setup, with special attention for the optical aspects. The pros and cons of different types of resist as well as the limitations and errors of the setup are discussed. The bottleneck in Laser Interference Lithography is the presence of internal reflection in the photo-resist layer. These reflections can be reduced by the use of antireflection coatings. However the thicknesses of these coatings depends on the angle of exposure and the material property or combination of materials in thin films. We show with some examples how to deal with this issue. Finally we show examples of more complex patterns that can be realized by multiple exposures.
Experimental Study on Ice Forming Process of Cryogenic Liquid Releasing underwater (2017)

Cryogenic liquid releasing into water would be a process combines hyperactive boiling with ice forming. There are still few researches on the experimental study on the environmental conditions for deciding ice forming speed and liquid surviving state. In this paper, to advance our understanding of ice forming deciding factors in the process of LN2 releasing underwater, a visualization experimental system is built. The results show that the pressure difference significantly influences the ice forming speed and liquid surviving distance, which is observed by the experiment and theoretically analysed by Kelvin-Helmholtz instability. Adding nucleating agent is helpful to provide ice nucleus which can accelerate the ice forming speed. Water flowing has some effect on changing pressure difference, which can affect the ice forming speed and liquid surviving distance.
Modeling and Simulation in Systems Engineering (2001)

Simulation and modeling are major assets in the engineering of systems of all types. This two-part series addresses the much expanded role for M&S that is due to the prospect that evolutionary and adaptive engineering efforts are the wave of the future. The Department of Defense's Simulation BasedAcquisition initiative is a case in point, but some critical issues need to be addressed to bring it to fruition. In this first part, we set the background in systems engineering, information technology and the new role of complex adaptive system models that are changing our view of organizations as machines to organizations as organisms.
Design and application of a C++ macromolecular class library. (1994)

PDBlib is an extensible object oriented class library written in C++ for representing the 3-dimensional structure of biological macromolecules. PDBlib forms the kernel of a larger software framework being developed for assiting in knowledge discovery from macromolecular structure data. The software design strategy used by PDBlib, how the library may be used and several prototype applications that use the library are summarized. PDBlib represents the structural features of proteins, DNA, RNA, and complexes thereof, at a level of detail on a par with that which can be parsed from a Protein Data Bank (PDB) entry. However, the memory resident representation of the macromolecule is independent of the PDB entry and can be obtained from other back-end data sources, for example, existing relational databases and our own object oriented database (OOPDB) built on top of the commercial object oriented database, ObjectStore. At the front-end are several prototype applications that use the library: Macromolecular Query Language (MMQL) is based on a separate class library (MMQLlib) for building complex queries pertaining to macromolecular structure; PDBtool is an interactive structure verification tool; and PDBview, is a structure rendering tool used either as a standalone tool or as part of another application. Each of these software components are described. All software is available via anonymous ftp from cuhhca.hhmi.columbia.edu.
Description of a new mutation and characterization of FGFR1, FGFR2, and FGFR3 mutations among Brazilian patients with syndromic craniosynostoses. (1998)

Dominant mutations in three fibroblast growth factor receptor genes (FGFRs1-3) cause Crouzon, Jackson-Weiss, Pfeiffer, and Apert syndromes. In the present study, 50 Brazilian patients with these four syndromes (27 Apert, 17 Crouzon, 5 Pfeiffer, and 1 Jackson-Weiss patients) were screened for mutations in the FGFR1-3 genes. Except for one, all the Apert patients had either S252W (n = 16) or P253R (n = 10) mutations. The remaining Apert case is atypical with a mutation altering the splice site of FGFR2 exon IIIc. The Pfeiffer patients had mutations in one of the FGFR genes: three in FGFR2, one in FGFR1, and one in FGFR3. In contrast, only 8 of the 17 Crouzon patients studied had a mutation in either FGFR2 (n = 7) or FGFR3 locus (n = 1). Mutations in the FGFR2 locus account for most (93%) of our syndromic craniosynostotic cases, whereas 5% had mutations in the FGFR3 locus and only 2% had mutations in the FGFR1 gene. Except for one, all the other mutations were reported previously in craniosynostotic patients from other populations. Interestingly, the mutation C278F, previously described in Crouzon and Pfeiffer cases, was here identified in a familial case with Jackson-Weiss. Also, unexpectedly, a common mutation altering the splice site of the FGFR2 exon IIIc was found in one Apert and two Pfeiffer patients. In addition, we identified a new mutation (A337P) in the FGFR2 exon IIIc associated with Crouzon phenotype.
Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial (2005)

Regular didgeridoo playing is an effective treatment alternative well accepted by patients with moderate obstructive sleep apnoea syndrome. Trial registration ISRCTN: 31571714.