gebhart/patrepeval huggingface dataset:
Bioadhesive Microporous Architectures by Self-Assembling Polydopamine Microcapsules for Biomedical Applications (2015)

Bioadhesive microporous architectures that mimic the functions of a natural extracellular matrix (ECM) were prepared by self-assembling polydopamine (PDA) microcapsules, which not only favor cell adhesion and growth, but also facilitate growth factor immobilization and release. PDA-coated polystyrene (PS) microspheres are synthesized by polymerization of dopamine on sulfonated PS microspheres and then assembled using positively charged chitosan (CHI) layers as link agents. After the PS core templates were removed, microporous architectures composed of PDA microcapsules were obtained. The produced microporous PDA architectures have a high capability of adsorbing BMP-2 and realize the sustained release of BMP-2. More importantly, the bioadhesive micro architecture and its immobilized BMP-2 synergistically enhance the activity and osteogenetic differentiation of bone marrow mesenchymal stem cells (BMSCs). Both supercell adhesion and BMP-2 immobilization ability of these architectures are attributed to the intrinsic adhesive nature of PDA and the porous architectures via the assembly of PDA microcapsules. The bioadhesive microporous PDA architectures with both cell affinitive and GF release features have a great potential to mimic natural ECM for modifying various medical devices in the fields of tissue engineering and regenerative medicine.
A Novel Phase-Locked Loop Based on Frequency Detector and Initial Phase Angle Detector (2012)

This paper proposes a new three-phase software phase-locked loop (PLL) that operates fast and accurately in unbalanced, polluted, and frequency deviating circumstances. The proposed PLL consists of a frequency detector and an initial phase angle detector. In the synchronous reference frame, the initial phase angle detector tracks a ramp phase angle, which is generated from frequency deviation of the inputs, with steady error. This detection error is utilized to estimate the actual grid frequency. Frequency adaptive moving average filters (MAFs) are applied in this new PLL to eliminate noises, harmonics, and negative sequence components. In this paper, the effect of discrete sampling on the MAFs is analyzed, and a linear interpolation is employed to enhance the performances of the MAFs. The stability of the proposed PLL is also analyzed, a sufficient stability condition is identified, and the design procedures of the control parameters are also presented. Simulations and experiments verify the performances of the novel PLL.
Association of Bovine Fibroblast Growth Factor 2 (FGF2) Gene with Milk Fat and Productive Life: An Example of the Ability of the Candidate Pathway Strategy to Identify Quantitative Trait Genes (2008)

Fibroblast growth factor 2 (FGF2) is expressed in the bovine mammary gland and may play a role in the development and reorganization of the mammary gland. It is also expressed by the uterine endometrium throughout the estrous cycle and early pregnancy. The FGF2 was chosen for this study because it regulates the expression of interferon-tau, a key member of the signal transduction pathway involved in milk production. In previous studies, we reported the association of several genes in this pathway with milk production and health traits in dairy cattle. The objective of this study was to examine the association of FGF2 polymorphisms with milk composition, somatic cell score, and productive life in 3 Holstein cattle populations from the United States and Israel. The pooled DNA sequencing approach was used to identify single nucleotide polymorphisms (SNP) in FGF2. Sequencing of a total of 6.4 kb including 3 exons of the gene revealed only one SNP (A/G) in intron 1 at position 11646. This SNP was investigated for association with production traits in 2,773 individuals from 3 Holstein populations: the granddaughter-design Cooperative Dairy DNA Repository and the daughter-design University of Wisconsin populations from the United States and a daughter-design population from Israel. For both the Israeli and the UW populations, FGF2 variants were associated with fat yield and percentage, somatic cell score, and productive life with significant dominance and complete dominance effects. For the Cooperative Dairy DNA Repository population, no significant associations were observed for the examined traits. Given that FGF2 was chosen for this study because of its role in the interferon-tau signal transduction pathway and was found to be associated with production traits, results suggest that the candidate pathway could be an attractive strategy to search for candidate quantitative trait genes.
Assessing the benefits of fine-grain parallelism in dataflow programs (1988)

A method for assessing the benefits of fine-grain parallelism in “real” programs is presented. The method is based on parallelism profiles and speedup curves derived by executing dataflow graphs on an interpreter under progressively more realistic assumptions about processor resources and communication costs. It is shown that programs, even using traditional algorithms, exhibit ample parallelism when parallelism is exposed at all levels, i.e., within expressions, across nested loops and function calls, and in producer-consumer relationships on individual elements of data structures. Since only dataflow graphs compiled from the high level language Id are considered, the bias introduced by the language and the compiler is examined. A method of estimating speedup through analysis of the ideal parallelism profile is developed, avoiding repeated execution of programs. It is shown that fine-grain parallelism can be used to mask large, unpredictable memory latency and synchronization waits in architectures employing dataflow instruction execution mechanisms. Finally, the effects of grouping portions of dataflow programs, such as function invocations or loop iterations, and requiring that the operators in a group execute on a single processor, are explored.
Insulin—like Growth Factor-1 is Partially Responsible for Fibroblast Proliferation Induced by Bronchoalveolar Lavage Fluid from Patients with Systemic Sclerosis (1994)

1. Interstitial lung disease is a common complication of systemic sclerosis. The mechanism by which excess collagen is deposited in the lung is poorly understood, but is thought to involve release of mediators which activate lung fibroblasts. In this study we investigated and partially characterized the fibroblast proliferative activity of bronchoalveolar lavage fluid from 29 patients with systemic sclerosis, 19 with and 10 without evidence of lung disease assessed by thin-section computed tomography. 2. Bronchoalveolar lavage fluid from both groups of patients stimulated fibroblast proliferation compared with control subjects: systemic sclerosis with normal computed tomography, 27.7 (range 10.5-57.9)% above control; systemic sclerosis with abnormal computed tomography, 26.7 (range 5.0-47.8)% above control, P < 0.02 in both cases. 3. The activity was reduced by about one-third by neutralizing antibodies to insulin-like growth factor-1 but not platelet-derived growth factor. Levels of insulin-like growth factor-1 of bronchoalveolar fluid were increased in patients with systemic sclerosis [2.10 (range 1.10-3.48) ng/ml of bronchoalveolar lavage fluid] compared with controls [1.45 (range 1.10-2.05) ng/ml; P < 0.01]. When patients were subdivided into those with abnormal computed tomography [2.10 (range 1.20-3.48) ng/ml] and those with normal computed tomography [1.85 (range 1.10-2.90) ng/ml] only the values for the group with evidence of lung disease were increased compared with control subjects (P < 0.02). Platelet-derived growth factor could not be detected in bronchoalveolar lavage fluid from any group. Fractionation of bronchoalveolar lavage fluid demonstrated activity in several fractions consistent with the molecular masses of insulin-like growth factor-1 associated with binding proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
Structure–Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1) (2017)

N-(1-Benzyl-4-piperidinyl)-2,4-dichlorobenzamide 5 (BPDBA) is a noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1). We here report the synthesis and structure-activity relationship of 71 analogues. We identify 26m as a more soluble 2,4-Cl substituted 3-pyridine analogue with retained BGT1 activity and an improved off-target profile compared to 5. We performed radioligand-based uptake studies at chimeric constructs between BGT1 and GAT3, experiments with site-directed mutated transporters, and computational docking in a BGT1 homology model based on the newly determined X-ray crystal structure of the human serotonin transporter (hSERT). On the basis of these experiments, we propose a binding mode involving residues within TM10 in an allosteric site in BGT1 that corresponds to the allosteric binding pocket revealed by the hSERT crystal structure. Our study provides first insights into a proposed allosteric binding pocket in BGT1, which accommodates the binding site for a series of novel noncompetitive inhibitors.
Synopsis diffusion for robust aggregation in sensor networks (2004)

Previous approaches for computing duplicate-sensitive aggregates in sensor networks (<i>e.g.</i>, in TAG) have used a tree topology, in order to conserve energy and to avoid double-counting sensor readings. However, a tree topology is not robust against node and communication failures, which are common in sensor networks. In this paper, we present <i>synopsis diffusion</i>, a general framework for achieving signi.cantly more accurate and reliable answers by combining energy-efficient multi-path routing schemes with techniques that avoid double-counting. Synopsis diffusion avoids double-counting through the use of <i>order- and duplicate-insensitive (ODI) synopses</i> that compactly summarize intermediate results during in-network aggregation. We provide a surprisingly simple test that makes it easy to check the correctness of an ODI synopsis. We show that the properties of ODI synopses and synopsis di.usion create <i>implicit</i> acknowledgments of packet delivery. We show that this property can, in turn, enable the system to adapt message routing to dynamic message loss conditions, even in the presence of asymmetric links. Finally, we illustrate, using extensive simulations, the significant robustness, accuracy, and energy-efficiency improvements of synopsis diffusion over previous approaches.
Association of Tapasin and COPI Provides a Mechanism for the Retrograde Transport of Major Histocompatibility Complex (MHC) Class I Molecules from the Golgi Complex to the Endoplasmic Reticulum (2002)

Tapasin is a subunit of the transporter associated with antigen processing (TAP). It associates with the major histocompatibility complex (MHC) class I. We show that tapasin interacts with beta- and gamma-subunits of COPI coatomer. COPI retrieves membrane proteins from the Golgi network back to the endoplasmic reticulum (ER). The COPI subunit-associated tapasin also interacts with MHC class I molecules suggesting that tapasin acts as the cargo receptor for packing MHC class I molecules as cargo proteins into COPI-coated vesicles. In tapasin mutant cells, neither TAP nor MHC class I are detected in association with the COPI coatomer. Interestingly, tapasin-associated MHC class I molecules are antigenic peptide-receptive and detected in both the ER and the Golgi. Our data suggest that tapasin is required for the COPI vesicle-mediated retrograde transport of immature MHC class I molecules from the Golgi network to the ER.
A novel approach for K-best MIMO detection and its VLSI implementation (2008)

Since the complexity of MIMO detection algorithms is exponential, the K-best algorithm is often chosen for efficient VLSI implementation. This detection problem is often viewed as a tree search problem where the breadth first search (BFS) method is adopted and only the K-best branches are kept at each level of the tree. An earlier VLSI implementation of the K-best BFS has been reported, however it has an inherent speed bottleneck due to the calculation of many path metrics and then sorting among them to select the K-best. In this paper an alternative implementation of the BFS is presented, which is suitable for VLSI implementation. To test the performance of this approach it has been applied to a 4X4 MIMO detector with a 64 QAM constellation. The results show less than 1 dB degradation from the sphere decoding algorithm. The implementation of a single spiral cell, the basic block behind the system, occupies a 764 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of area and consumes a 52.58 muw of power a 0.13 mum CMOS technology.
Designing a training program which delivers results quickly! (2002)

A well‐designed and executed training program minimizes new employee “on‐boarding” time and time‐to‐first‐contribution. This paper presents considerations for the design of a two‐phase training program for new employees – an initial program (addressing training requirements of a general group), and a detailed program (requiring skill mastery by individual functional area). A process involving frequent employee‐leader reviews and employing the skills of peer coaches and mentors is proposed. The effectiveness of the training program can be more accurately assessed via a leadership team review of expected versus actual progress against the training program objectives. After initial cycles of this process at Solutia Inc., learnings and next steps have been identified.
Enhancement of the CDC ovitrap with hay infusions for daily monitoring of Aedes aegypti populations. (1991)

An ovitrap containing hay infusion and a second ovitrap adjacent to it containing a 10% dilution of the infusion in tap water together yielded 8 times more Aedes aegypti eggs than single CDC ovitraps containing tap water. These "enhanced pairs" were significantly more attractive than pairs with other combinations of infusion, water or methyl propionate, and have proven useful for daily monitoring of Ae. aegypti populations. Our results shed light on the oviposition behavior of Ae. aegypti in the field.
Exploiting modularity in template-controlled synthesis: a new linear template to direct reactivity within discrete hydrogen-bonded molecular assemblies in the solid state (2001)

Co-crystallization of 1,8-naphthalenedicarboxylic acid (1,8-nap) with trans-1,2-bis(n-pyridyl)ethylene (n,n'-bpe) (n = 2 or 4) yields a discrete four-component molecular assembly, 2(n,n'-bpe).2(1,8-nap) 1, that is held together by four O-H...N hydrogen bonds where the dicarboxylic acid, serving as a linear template, directs alignment of olefins in the solid state for [2 + 2] photoreaction.
Dual-Microphone Voice Activity Detection Technique Based on Two-Step Power Level Difference Ratio (2014)

In this paper, we propose a novel dual-microphone voice activity detection (VAD) technique based on the two-step power level difference (PLD) ratio. This technique basically exploits the PLD between the primary microphone and the secondary microphone in a mobile device when the distance between the microphones and the sound source is relatively short. Based on the PLD, we propose the use of the PLD ratio (PLDR) instead of the original PLD to take advantage of the relative difference between the PLD of speech and the PLD of noise. Indeed, the PLDR is obtained by estimating the ratio of the PLD between the input signals and the PLD between the two channel noises during periods without speech. The proposed technique offers a two-step algorithm using the PLDRs including long-term PLDR (LT-PLDR), which characterizes long-term evolution and short-term PLDR (ST-PLDR), which characterizes short-time variation during the first step. LT-PLDR-based and ST-PLDR-based VAD decision are performed using the maximum a posteriori (MAP) probability derived from the model-trust algorithm and combined at the second step to reach a superior VAD decision for both long-term and short-term situations. Extensive experimental results show that the proposed dual-microphone VAD technique outperforms the conventional two-channel VAD method as well as most standardized VAD algorithms.
Vertically Coupled Silicon Nitride Microdisk Resonant Filters (2014)

Polarization-dependent vertically coupled microdisk resonant filters are experimentally demonstrated based on a multilayer silicon nitride platform. An improved planarization technique based on conventional chemical-mechanical polishing and dry-etching is adopted to flatten the gap film surface for a different core layer deposition after the first-layer photonic circuit is formed. The resonator can realize a high quality factor (> 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> ) and large suppression value (>20 dB) for the transverse electric light, while the transverse magnetic wave has weak resonant coupling. Other vertically coupled multifunctional devices can be further expected based on the current integration method. A cascaded resonator filter with superior characteristics, such as a flat passband, a steep roll-off, and an enhanced suppression ratio is developed.
Multiscale Point Cloud Geometry Compression (2020)

Recent years have witnessed the growth of point cloud based applications because of its realistic and fine-grained representation of 3D objects and scenes. However, it is a challenging problem to compress sparse, unstructured, and high-precision 3D points for efficient communication. In this paper, leveraging the sparsity nature of point cloud, we propose a multiscale end-to-end learning framework which hierarchically reconstructs the 3D Point Cloud Geometry (PCG) via progressive re-sampling. The framework is developed on top of a sparse convolution based autoencoder for point cloud compression and reconstruction. For the input PCG which has only the binary occupancy attribute, our framework translates it to a downscaled point cloud at the bottleneck layer which possesses both geometry and associated feature attributes. Then, the geometric occupancy is losslessly compressed using an octree codec and the feature attributes are lossy compressed using a learned probabilistic context model.Compared to state-of-the-art Video-based Point Cloud Compression (V-PCC) and Geometry-based PCC (G-PCC) schemes standardized by the Moving Picture Experts Group (MPEG), our method achieves more than 40% and 70% BD-Rate (Bjontegaard Delta Rate) reduction, respectively. Its encoding runtime is comparable to that of G-PCC, which is only 1.5% of V-PCC.
Flexible fluorocarbon wire coatings by pulsed plasma enhanced chemical vapor deposition (1997)

A method to coat thin wires, 25 μm in diameter, with fluorocarbon material that is flexible and conformal has been achieved using pulsed plasma enhanced chemical vapor deposition (PECVD). This process enables the chemical composition of the films to be tailored in order to achieve similar stoichiometry and chemical composition to bulk polytetrafluoroethylene [PTFE, (CF2)n, Teflon™]. The deposited film had a F/C ratio of 1.9 and a CF2 fraction of 65%. In comparison, a film deposited under continuously applied power had a F/C ratio of only 1.6 and a CF2 fraction of 32% and was found to form brittle wire coatings. The flexibility of the pulsed PECVD film was consistent with its connectivity number of 2.1 corresponding to an underconstrained, flexible material. In addition, the connectivity number for the brittle film was 2.5, consistent with an overconstrained brittle network.
A new desk-top encounter-type haptic device with an actively driven pen-tablet LCD panel (2013)

In conventional haptic devices for virtual reality (VR) systems, a user interacts with a scene by handling a tool (such as a pen) using a mechanical device (i.e. an end-effector-type haptic device). In the case that the device can ‘mimic’ a VR object, the user can interact directly with the VR object without the mechanical constraint of a device (i.e. an encounter-type haptic device). A new challenge of an encounter-type haptic device is displaying the visuals and haptic information simultaneously on a single device. We are proposing a new desk-top encounter-type haptic device with an actively driven pen-tablet LCD panel. The proposed device is capable of providing pseudo-3D visuals and haptic information on a single device. As the result, the system provides to the user a sense of interaction with a real object. To develop a proof-of-concept prototype, a compact parallel mechanism was developed and implemented. The aim of this research is to propose a new concept in haptic research. In this paper, the concept, the prototype, and some preliminary evaluation tests with the proposed system are presented.
Kinetics of Proinsulin Conversion in Human Islets (1993)

Islets isolated from human cadaver pancreas were pulse-labeled (10 min with [3H]leucine) and then incubated for a 180-min chase. Islets and chase medium were collected every 15 min and analyzed by reversed-phase HPLC to quantify the percentage of radioactively labeled proinsulin, conversion intermediates, and fully processed insulin. Release of proinsulin-related labeled products into the chase medium was < 10% of total. Whereas 50% of labeled proinsulin had been lost by conversion within 45 min, fully processed insulin only appeared with a half-time of 100 min. This discrepancy is attributable to accumulation of radioactive conversion intermediates. Des 64.65 split proinsulin was a minor component, reaching a maximum of 5.2 +/- 1.7% (n = 4) at 60 min of chase. By contrast, des 31.32 split proinsulin--and a truncated form lacking the first three residues of C-peptide--rose progressively to 29.3 +/- 1.4% by 75 min, and declined thereafter. The accumulation of des 31.32 split proinsulin rather than the des 64.65 split form during the conversion of human proinsulin reflects slower conversion at the C-peptide/A-chain than at the B-chain/C-peptide junction, and is consistent with the appearance of this particular conversion intermediate in the circulation.
Blind adaptation of zero forcing projections and oblique pseudo-inverses for subspace detection and estimation when interference dominates noise (2002)

In much of modern radar, sonar, and wireless communication, it seems more reasonable to model "measurement noise" as subspace interference-plus-broadband noise than as colored noise. This observation leads naturally to a variety of detection and estimation problems in the linear statistical model. To solve these problems, one requires oblique pseudo-inverses, oblique projections, and zero-forcing orthogonal projections. The problem is that these operators depend on knowledge of signal and interference subspaces, and this information is often not at hand. More typically, the signal subspace is known, but the interference subspace is unknown. We prove a theorem that allows these operators to be estimated directly from experimental data, without knowledge of the interference subspace. As a byproduct, the theorem shows how signal subspace covariance may be estimated. When the strict identities of the theorem are approximated, then the detectors, estimators, and beamformers of this paper take on the form of adaptive subspace estimators, detectors, and Capon beamformers, all of which are reduced in rank. The fundamental operator turns out to be a certain reduced-rank Wiener filter, which we clarify in the course of our derivations. The results of this paper form a foundation for the rapid adaptation of receivers that are then used for detection and estimation. They may be applied to detection and estimation in radar, sonar, and hyperspectral imaging and to data decoding in multiuser communication receivers.