gebhart/patrepeval huggingface dataset:
Synthesis of tetrahydrofurans from active methylene compounds via radical cyclization (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of tetrahydrofurans from active methylene compounds via radical cyclizationOsamu Moriya, Yoshikiyo Urata, Yoshikazu Ikeda, Yoshio Ueno, and Takeshi EndoCite this: J. Org. Chem. 1986, 51, 24, 4708–4709Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/jo00374a038https://doi.org/10.1021/jo00374a038research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. (2003)

Peroxisome proliferator-activated receptor (PPAR) gamma is an important signaling molecule in cells of mesenchymal origin, inducing differentiation and regulating cell proliferation in several cell types such as vascular smooth muscle cells. Leiomyomas arise from smooth muscle cells of the uterine myometrium with an incidence rate as high as 70% in women of reproductive age. PPAR signaling has not been characterized in these tumors, although prostaglandins, natural PPAR ligands, are known effectors of key biological functions in the normal myometrium. Leiomyomas and tumor-derived cells isolated from a rat model for this disease were characterized by Western analysis and found to express all three PPAR isoforms, suggesting that signaling pathways mediated by these receptors were intact in this tumor type. In vitro experiments with a leiomyoma-derived cell line demonstrated that the pan-PPAR ligand cis-4,7,10,13,16,19-docosahexaenoic acid and PPARgamma-specific ligands 15-deoxy-delta(12,14)-prostaglandin J(2), troglitazone, and ciglitazone inhibited 17beta-estradiol-stimulated cell proliferation. This inhibitory effect was not observed with PPARalpha- or PPARbeta-specific ligands. Although both PPAR and estrogen receptor (ER) signaling pathways were intact in leiomyoma cells, in addition to growth inhibition, stimulation of PPARgamma signaling also inhibited ER-mediated gene expression. Human leiomyomas were also found to express all three PPAR isoforms, and primary cultures of these cells were sensitive to the inhibitory effects of PPARgamma ligands. These results suggest that in uterine leiomyomas PPARgamma activation is growth inhibitory and that this inhibition is mediated at least in part by negative cross-talk between ER and PPAR signaling pathways.
Development of an Excipient-Free Peptide Dry Powder Inhalation for the Treatment of Pulmonary Fibrosis (2020)

The caveolin scaffolding domain peptide (CSP) is being developed for the therapeutic intervention of a lethal lung disease, idiopathic pulmonary fibrosis. While direct respiratory delivery of CSP7 (a 7-mer fragment of CSP) is considered an effective route, proper formulation and processing of the peptide are required. First, air-jet milling technology was performed in order to micronize the neat peptide powder. Next, the fine particles were subjected to a stability study with physical and chemical characterizations. In addition, the <i>in vivo</i> efficacy of processed CSP7 powder was evaluated in an animal model of lung fibrosis. The results revealed that, with jet milling, the particle size of CSP7 was reduced to a mass median aerodynamic diameter of 1.58 ± 0.1 μm and 93.3 ± 3.3% fine particle fraction, optimal for deep lung delivery. A statistically significant reduction of collagen was observed in diseased lung tissues of mice that received CSP7 powder for inhalation. The particles remained chemically and physically stable after micronization and during storage. This work demonstrated that jet milling is effective in the manufacturing of a stable, excipient-free CSP7 inhalation powder for the treatment of pulmonary fibrosis.
London, Queen Elizabeth Hall: Carter's ‘Dialogues’ (2004)

It's been more than 40 years since Elliott Carter wrote a concertante work for piano and orchestra: the 1963 Piano Concerto was one of the high watermarks of the complexity and richness of his early maturity. His latest piece is Dialogues for piano and large ensemble, and at its dazzlingly expressive world premiere performance on 23 January, by its commissioners and dedicatees, pianist Nicolas Hodges and the London Sinfonietta, conducted by Oliver Knussen, the work was revealed as one of the most significant of Carter's recent catalogue.
Trust and expectation on psychiatrist and its correlation with satisfaction and adherence in patients with mental illness (2015)

Background Trust and expectation are important aspect of doctor patient relationship and its role in patient’s satisfaction and medication adherence is unclear. Objective To study the levels of trust and expectation on psychiatrist and its relationship with patient’s satisfaction and treatment adherence. Methods One hundred and twenty three consecutive outpatients were recruited on follow-up if they satisfied the selection criteria. They were assessed with socio-demographic and clinical proforma designed for this study, Patient Trust Scale, Patient Satisfaction Survey, Patient Expectations Questionnaire and Medication Adherence Rating Scale. Results There was a high mean score on trust scale (Mean 38.9, SD 8.5) and expectation questionnaire (Mean 13.5, SD 3.3). On Kruskal-Wallis H test significant group differences were observed in nuclear vs joint family type (c2 = 18.496, h2 = .151, df = 1, Sig. = .000) and knowledge of treatment option (medication only vs medication + psychotherapy) treatment option (c2 = 18.100, h2 = .148, df = 2, Sig. = .000) and occupational status (employed vs unemployed) (c2 = 3.165, h2 =.029, df = 1, Sig. = .056) on the score of PTS. Similar differences were also observed in method of treatment sought before (no treatment vs allopathic) (c2 = .065, h2 = .065, df = 3, Sig. = .005), knowledge about treatment option (medication only vs medication + psychotherapy) (c2 = .026, h2 = .161, df = 2, Sig. = .000) and occupation (employed vs unemployed) (c2 = .061, h2 = .061, df = 1, Sig. = .006) on the score of PEQ. On regression analysis (R2 = .723, F = 156.46, p = .000) value of the score on patient satisfaction was statistically significant as predicted by score on measure of expectation (beta = -0.095, t = -1.966, p = 0.052) and trust (beta = .842, t = 17.504, p = .000). Discussion Levels of patients trust and expectation on physician varies with knowledge about treatment option & occupational status, and significantly associated with levels of satisfaction.
High power 1060-nm raised-ridge strained single-quantum-well lasers (2005)

We report a high kink-free facet power of 852 mW and a high single-wavelength facet power of 350 mW for 1060-nm raised-ridge Fabry-Perot (FP) and distributed-feedback (DFB) lasers, respectively.
The search for a biochemical marker in alcoholism. (1983)

A diagnostic aid using routinely available blood chemistry batteries is being developed which shows promise for use in identification of individuals with drinking problems as well as in individuals having alcoholic and nonalcoholic liver disease. A statistically complex form of pattern recognition known as quadratic discriminant analysis is performed on common clinical laboratory tests such as total protein, total bilirubin, phosphorus, chloride, carbon dioxide, glucose, WBCs, RBCs, and MCV values. The relationship of each of the tests to each other is analyzed, providing a type of biochemical "fingerprint," such that any one test may not be unique. Rather, the interrelationships to one another provide a unique statistical profile of an alcoholic, or an individual with alcoholic or nonalcoholic liver disease.
New tolerance factor to predict the stability of perovskite oxides and halides (2019)

Predicting the stability of the perovskite structure remains a long-standing challenge for the discovery of new functional materials for many applications including photovoltaics and electrocatalysts. We developed an accurate, physically interpretable, and one-dimensional tolerance factor, τ, that correctly predicts 92% of compounds as perovskite or nonperovskite for an experimental dataset of 576 <i>ABX</i> <sub>3</sub> materials (<i>X</i> = O<sup>2-</sup>, F<sup>-</sup>, Cl<sup>-</sup>, Br<sup>-</sup>, I<sup>-</sup>) using a novel data analytics approach based on SISSO (sure independence screening and sparsifying operator). τ is shown to generalize outside the training set for 1034 experimentally realized single and double perovskites (91% accuracy) and is applied to identify 23,314 new double perovskites (<i>A</i> <sub>2</sub> <i>BB'X</i> <sub>6</sub>) ranked by their probability of being stable as perovskite. This work guides experimentalists and theorists toward which perovskites are most likely to be successfully synthesized and demonstrates an approach to descriptor identification that can be extended to arbitrary applications beyond perovskite stability predictions.
Biochemical separation of a human B cell mitogenic factor. (1982)

Recent studies have established the ability of human B lymphocytes to undergo G1-phase cell cycle progression and subsequent DNA synthesis upon exposure to factor(s) present in media conditioned by lectin-stimulated mononuclear cells. Procedures for the isolation of such a cytokine have been the focus of the present investigation. Conditioned medium from cells stimulated by lectin for 72 hr was fractionated by ammonium sulfate precipitation, ion-exchange chromatography, and gel filtration chromatography. During the isolation procedure the proliferation-stimulating activity of the column fractions was assayed concurrently on purified human T cells, purified human B cells, and murine thymocytes. T cell and B cell stimulatory factors present in the initial conditioned medium were found to copurify during ammonium sulfate precipitation, DEAE-Sephadex chromatography, and Bio-Gel P-30 gel filtration. However, partial separation of these two activities was achieved after Bio-Gel P-100 gel filtration. Analytic polyacrylamide gel electrophoresis of radiolabeled Bio-Gel P-100 column fractions demonstrated a distinct protein band of 14,000-15,000 daltons in those column fractions predominantly supporting T cell growth and a distinct protein band of 12,000-13,000 daltons for those fractions predominantly supporting B cell growth. The fractions associated with B cell mitogenic activity induced B cell S-phase entry in a proportion of B lymphocytes in the absence of any detectable IgM secretion.
Elimination of theophylline metabolites in healthy adults (1997)

The metabolism of theophylline (TP) (540 mg per os) was determined by measuring plasma and saliva concentrations of TP and its metabolites, 0–24 h after loading, and urinary excretion 0–48 h after loading. TP and its five metabolites were separated and quantified by combining high-performance liquid chromatography and capillary electrophoresis. In addition to TP, 1,3-U, 3-X and 1-U were consistently found in plasma and saliva. The area under the plasma concentration-time curve (AUC) showed that TP accounted for 91±4% (mean+SD) of the total AUC in plasma with 1,3-U accounting for 3.1±1.4%, 3-X for 3.4±1.8% and 1-U for 2.5±1.5%. The urine analyses showed that unchanged TP accounted for 19±5% of total excretion, the remainder being 1, 3-dimethyluric acid (1,3-U, 41±6%), 1-methylxanthine (1-X, 2±0.8%), 1-meth-yluric acid (1-U, 26±6%), 3-methyxanthine (3-X, 11 ±3%) and 3-methyluric acid (3-U, 1±0.3%). Highest excretion rates were observed for 1,3-U (70±29 umol/ h), 1-U (40±26 μmol/h) and 3-X (20±15 μmol/h) 6–9 h after TP ingestion suggesting the high excretion of 1,3-U, 1-U and 3-X by the kidneys. The highest excretion rate of TP (50±8 μmol/h) occurring at 0–6 h after the load and rapidly declining thereafter, indicated the lower excretion of TP compared with its metabolites. N3-demethylation of TP accounted for 34±6% of the urinary metabolites, N1-demethylation of TP for 15±3% and C8-oxidation of TP for 51±9%. C8-oxidation of 1-X and 3-X was 93±4% and 9±4%, respectively, of the excreted amount of monomethylxanthine plus formed monomethylurate. Since the extent of all metabolic reactions remained constant during the load, it is suggested that TP is metabolized by hepatic reactions that occurred simultaneously and not sequentially.
Density enhancement near lower hybrid resonance layer in m=0 helicon wave plasmas (2001)

Radial density profiles are measured with various frequencies, powers, pressures, and gas masses in m=0 helicon wave plasmas. The radial density profiles show clear mode changes for the E mode (capacitive coupling), the H mode (inductive coupling), and the W mode (wave coupling) as the rf (radio frequency) power increases. The radial density profile hardly changes as the frequency varies in the E and the H modes but changes substantially in the W mode; it changes from a central peak profile to a hollow density profile near the lower hybrid resonance frequency. The change of radial density profile near the lower hybrid resonance frequency occurs only at pressures below 20 mTorr, and the resonance effects become very weak at higher pressures. The change of the radial density profile may be explained by the density enhancement near the lower hybrid resonance layer. The experiments with various magnetic fields and gas masses show a close correlation between the lower hybrid frequencies and the density profile changes.
Inhibitory effects of plant-produced phenols on algal growth. (2002)

植物が生産するフェノール類;カフェー酸(CFA),p-クマル酸(CA),フェルラ酸(FA),プロトカテキュ酸(PCA),シナピン酸(SIA),シリンガ酸(SYA),バニリン酸(VA),カテコール(CAT),ヒドロキノン(HQ),キナ酸(QA),シキミ酸(SA),この他,フェノール(PHE),レソルシノール(RES),ヒドロキシヒドロキノン(HHQ),フロログルシノール(PHL)の藍藻類Microcystis aeruginosaに対する増殖抑制効果を評価した。上記物質の中では,多価フェノールCFA,PCA,CAT,HQ,HHQ,PHL,メトキシ基を有するフェノールSIA,SYAがM.aeruginosaの増殖を抑制した。これらの物質の構造と増殖抑制効果とを比較した結果,多価フェノールの中でも水酸基が互いにo-位やp-位にあるものの抑制効果は,m-位にのみ水酸基を有するものよりも強かった。また,多価フェノールの自動酸化挙動を評価した結果,自動酸化する多価フェノールのみがM.aeruginosaに対して顕著な効果を示すことが明らかとなり,多価フェノールの自動酸化が増殖抑制効果を誘導していることが示唆された。さらに,自動酸化により生成するラジカルの存在時間や多価フェノールの自動酸化の進行と増殖抑制効果との関係を評価した結果,多価フェノールによるM.aeruginosaの増殖抑制機構として「ラジカルや他の自動酸化生成物がM.aeruginosaの細胞に直接的なダメージを与えたり,代謝活動を阻害する」が提案された。但し,増殖抑制効果の主な要因となる物質はラジカル以外の自動酸化生成物であることが示唆された。
Beneficial Effects of Coating Alginate Microcapsules with Macromolecular Heparin Conjugates– <i>In Vitro</i> and <i>In Vivo</i> Study (2013)

Pericapsular fibrotic overgrowth (PFO) is associated with poor survival of encapsulated pancreatic islets. Modification of the microcapsule membrane aimed at preventing PFO should improve graft survival. This study investigated the effect of macromolecular Corline Heparin Conjugate (CHC) binding on intrinsic properties of alginate microcapsules and assessed the anti-fibrotic potential of this strategy both in vitro and in vivo. CHC was bound to alginate microcapsules using a layer-by-layer approach incorporating avidin. CHC binding to alginate microcapsule was visualized by confocal microscopy. Effects of CHC binding on microcapsule size, strength, and permeability were assessed, and the anti-clotting activity of bound CHC was determined by coagulation assay. Effect of CHC binding on the viability of encapsulated human islets was assessed in vitro, and their ability to function was assessed both in vitro and in vivo in diabetic immunodeficient mice. The potential of bound CHC to reduce PFO was assessed in vivo in different rat transplantation models. Confocal microscopy demonstrated a uniform coating of CHC onto the surface of microcapsules. CHC binding affected neither size nor permeability but significantly increased the tensile strength of alginate microcapsules by ~1.3-fold. The bound CHC molecules were stable and retained their anti-clotting activity for 3 weeks in culture. CHC binding affected neither viability nor function of the encapsulated human islets in vitro. In vivo CHC binding did not compromise islet function, and diabetes was reversed in all recipients with mice exhibiting lower blood glucose levels similar to controls in oral glucose tolerance tests. CHC binding was beneficial and significantly reduced PFO in both syngeneic and allogeneic rat transplantation models by ~65% and ~43%, respectively. In conclusion, our results show a new method to successfully coat CHC on alginate microcapsules and demonstrate its beneficial effect in increasing capsule strength and reduce PFO. This strategy has the potential to improve graft survival of encapsulated human islets.
Couple-group consensus for second-order multi-agent systems with the effect of second-order neighbours’ information (2017)

This paper investigates a couple-group consensus problem of second-order multi-agent systems with the impact of second-order neighbours’ information. For systems with/without time delays, couple-group consensus criteria are established in the form of linear matrix inequalities by utilizing both model transformation and stability theories. The main results indicate that the group consensus for multi-agent systems under the effect of second-order neighbours’ information can be achieved based on the premise of a generalized balanced couple. Finally, illustrative examples are presented to demonstrate the effectiveness of the theoretical results.
Face à l’obscurantisme (2007)

info:eu-repo/semantics/published
Bounds on the interchannel interference of OFDM in time-varying impairments (2001)

In this article, tight and universal bounds have been derived for the interchannel interference (ICI) of an orthogonal frequency-division multiplexing (OFDM) signal resulting from Doppler spread. The universal bound depends only on the product of the maximum Doppler frequency and the OFDM symbol duration. The tight bound also depends on the variance of the Doppler spectrum. Compared with the exact ICI expressions derived by other researchers, these bounds are easier to evaluate and can provide useful insight.
Gene targeting in the silkworm by use of a baculovirus (1999)

The Bombyx mori fibroin light (L)-chain gene was cloned and the green fluorescent protein (GFP) gene inserted into exon 7. The chimeric L-chain-GFP gene was used to replace the polyhedrin gene of Autographa californica nucleopolyhedrovirus (AcNPV). This recombinant virus was used to target the L-chain-GFP gene to the L-chain region of the silkworm genome. Female moths were infected with the recombinant virus and then mated with normal male moths. Genomic DNA from their progenies was screened for the desired targeting event. This analysis showed that the chimeric gene had integrated into the L-chain gene on the genome by homologous recombination and was stably transmitted through generations. The chimeric gene was expressed in the posterior silk gland, and the gene product was spun into the cocoon layer.
Adaptive Reconstruction of Surfaces and Scalar Fields from Dense Scattered Trivariate Data (1995)

In this paper, we propose an approach to model a set of trivariate dense and scattered data on an unknownmanifold by the zero contour of the C 1 piecewise tri-quadratic or tri-cubic polynomial. The C 1 function approximates the data over an octree-like mesh in an adaptive fashion. At the same time, and applying the same techniques, a scalar field (scalar values associated with the sampled surface points) is also modeled as a C 1 piecewise polynomial function defined on the reconstructed surface. The reconstructed surface and field can be used to visualize and interact with the data in a variety of ways. 1 Introduction In many important cases, a physical phenomenon is measured by sampling the value of a scalar or vector field at points on the surface of some object. For example, one might have sampled the temperature on the surface of a jet-engine, or the acceleration of a fluid flow on the wing of an airplane. Other cases of interest are electroencephalogram data on the surface ...
Reaction of Haloazoxybenzenes with Sulfuric Acid (1982)

Abstract Treatment of 4,4′-dihaloazoxybenzenes with sulfuric acid afforded 4,4′-dihaloazobenzenes (6) as the major product and 5-halo-2-(p-halophenylazo)phenols, the Wallach rearrangement products as minor products, besides 2-halo-5-(p-halophenylazo)phenols, 2-halo-4-(p-halophenylazo)phenols, and 4-(p-halophenylazo)phenols as abnormal rearrangement products. The reaction of fluoro compound gave the azophenols (3a or 5a) in the best yields. However, the ratio of 3a to 5a was found to vary with the concentration of sulfuric acid. Treatment of 4-haloazoxybenzenes with sulfuric acid gave 4-(p-halophenylazo)phenols and 4-haloazobenzenes (13) as major products together with 2-(p-halophenylazo)phenols and 5-halo-2-(phenylazo)phenols as minor products. Yields of reduction products 6 and 13 increased as the halosubstituent became heavier in the following sequence: F→Cl→Br→I.
An in vivo study of the role of the tumor cell cytoskeleton in tumor cell-platelet-endothelial cell interactions. (1990)

We recently reported that disruption of tumor cell microfilaments or intermediate filaments resulted in an inhibition of the ability of tumor cells to induce the aggregation of homologous platelets in vitro (H. Chopra et al., Cancer Res., 48: 3787-3800, 1988). Previous investigators demonstrated that disruption of the tumor cell cytoskeleton decreases the ability of these cells to form lung colonies. We proposed that this latter effect is due, in part, to decreased interaction of tumor cells with platelets, following their arrest in the microvasculature. To test this hypothesis, B16 amelanotic melanoma cell microtubules, microfilaments, or vimentin intermediate filaments were disrupted with colchicine (50 microns), cytochalasin D (50 microns), or cycloheximide (50 microns), respectively, and then cells were tail vein injected into syngeneic mice. Both cytochalasin D- and cycloheximide-treated cells formed fewer lung colonies than did control cells. Colchicine, however, failed to inhibit lung colony formation. Neither colchicine nor cycloheximide treatment altered initial pulmonary arrest; however, fewer cycloheximide-treated cells remained in the lungs 8 h postinjection. Greater than 90% of control or colchicine-treated cells were found to be associated with activated platelets, and they also demonstrated typical cell membrane process formation 10 min and 8 h post-tumor cell injection. In contrast, less than 10% of cycloheximide-treated cells were in contact with activated platelets 10 min postinjection. However, by 8 h approximately 90% of cycloheximide-treated cells were in contact with activated platelets. This recovery coincided with the reformation of the B16 amelanotic melanoma vimentin intermediate filament network and the reacquisition of the ability to induce platelet aggregation in vitro. Neither colchicine nor cycloheximide treatment altered initial B16 amelanotic melanoma cell adhesion to murine microvessel-derived endothelial cells. This study provides in vivo evidence in support of our previous findings that disruption of certain cytoskeletal elements (i.e., vimentin intermediate filaments) inhibits the tumor cell ability to activate platelets. This study also suggests that platelet activation may stabilize the initial tumor cell arrest in the microvasculature.