gebhart/patrepeval huggingface dataset:
Probabilistic Forecasting of Photovoltaic Generation: An Efficient Statistical Approach (2016)

A novel efficient probabilistic forecasting approach is proposed to accurately quantify the variability and uncertainty of the power production from photovoltaic (PV) systems. Distinguished from most existing models, a linear programming-based prediction interval construction model for PV power generation is established based on an extreme learning machine and quantile regression, featuring high reliability and computational efficiency. The proposed approach is validated through the numerical studies on PV data from Denmark.
Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells (2013)

TANK-binding kinase 1 (TBK1) has emerged as a novel therapeutic target for unspecified subset of lung cancers. TBK1 reportedly mediates prosurvival signaling by activating NF-κB and AKT. However, we observed that TBK1 knockdown also decreased viability of cells expressing constitutively active NF-κB and interferon regulatory factor 3. Basal phospho-AKT level was not reduced after TBK1 knockdown in TBK1-sensitive lung cancer cells, implicating that TBK1 mediates unknown survival mechanisms. To gain better insight into TBK1 survival signaling, we searched for altered phosphoproteins using mass spectrometry following RNAi-mediated TBK1 knockdown. In total, we identified 2,080 phosphoproteins (4,621 peptides), of which 385 proteins (477 peptides) were affected after TBK1 knockdown. A view of the altered network identified a central role of Polo-like kinase 1 (PLK1) and known PLK1 targets. We found that TBK1 directly phosphorylated PLK1 in vitro. TBK1 phosphorylation was induced at mitosis, and loss of TBK1 impaired mitotic phosphorylation of PLK1 in TBK1-sensitive lung cancer cells. Furthermore, lung cancer cell sensitivity to TBK1 was highly correlated with sensitivity to pharmacological PLK inhibition. We additionally found that TBK1 knockdown decreased metadherin phosphorylation at Ser-568. Metadherin was associated with poor outcome in lung cancer, and loss of metadherin caused growth inhibition and apoptosis in TBK1-sensitive lung cancer cells. These results collectively revealed TBK1 as a mitosis regulator through activation of PLK1 and also suggested metadherin as a putative TBK1 downstream effector involved in lung cancer cell survival.
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration (2007)

During trans-endothelial migration (TEM), leukocytes use adhesion receptors such as intercellular adhesion molecule-1 (ICAM1) to adhere to the endothelium. In response to this interaction, the endothelium throws up dynamic membrane protrusions, forming a cup that partially surrounds the adherent leukocyte. Little is known about the signaling pathways that regulate cup formation. In this study, we show that RhoG is activated downstream from ICAM1 engagement. This activation requires the intracellular domain of ICAM1. ICAM1 colocalizes with RhoG and binds to the RhoG-specific SH3-containing guanine-nucleotide exchange factor (SGEF). The SH3 domain of SGEF mediates this interaction. Depletion of endothelial RhoG by small interfering RNA does not affect leukocyte adhesion but decreases cup formation and inhibits leukocyte TEM. Silencing SGEF also results in a substantial reduction in RhoG activity, cup formation, and TEM. Together, these results identify a new signaling pathway involving RhoG and its exchange factor SGEF downstream from ICAM1 that is critical for leukocyte TEM.
The Battle Over Evolution: How Geoscientists Can Help (2005)

Eighty years after the Scopes trial, evolution is still under attack in the public school science classroom. Geoscientists are in a unique position to help, but in order to do so, they need to appreciate the history of the controversy, to understand the variety of ways in which creationists attempt to compromise evolution education, and to work together to use their scientific expertise effectively in the education policy arena.
Handle with Care: Domestic Violence Safety Planning in the Age of Data Privacy Laws (2021)

The United States has been patiently waiting for a comprehensive federal data privacy law to protect consumers. However, strong data privacy laws can also protect a less thought-about group: survivors of domestic violence and intimate partner violence. As new technology proliferates into our daily lives, technology-based abuse is quickly becoming a common form of intimate partner abuse. Domestic violence survivors and advocates have to stay extra vigilant about who has access to their internet data. Needing to understand technology-specific safety measures and learn technology-literacy skills adds more work to already overwhelmed domestic violence advocates and survivors. Could the law serve to take on some of the work to protect survivors from tech-based abuse without further shrinking their autonomy and complexity in their experiences? While new data privacy laws in the European Union and California were crafted with consumer rights in mind, they can be used to protect the rights of domestic violence survivors, whether through direct application or by inspiration. This article explores the extent that legal relief is available for domestic violence survivors in Washington state–especially for survivors of technology-based abuse–and how data privacy laws could augment and expand available legal relief, particularly options that can lessen a survivor’s reliance on the criminal justice system. An intersectional analysis of domestic violence reveals the harm of a singular narrative of intimate partner abuse and sheds light on the shortcomings of criminal laws as the sole source of relief for victims of tech-based abuse. Enacting data privacy laws that provide heighten protection over the data of survivors of domestic violence and intimate partner violence can not only provide additional technology safeguards to protect survivors, but also reignite the conversation on a private right of action for violence against women and intimate partners.
MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis (1997)

MLN64 is a protein that is highly expressed in certain breast carcinomas. The C terminus of MLN64 shares significant homology with the steroidogenic acute regulatory protein (StAR), which plays a key role in steroid hormone biosynthesis by enhancing the intramitochondrial translocation of cholesterol to the cholesterol side-chain cleavage enzyme. We tested the ability of MLN64 to stimulate steroidogenesis by using COS-1 cells cotransfected with plasmids expressing the human cholesterol side-chain cleavage enzyme system and wild-type and mutant MLN64 proteins. Wild-type MLN64 increased pregnenolone secretion in this system 2-fold. The steroidogenic activity of MLN64 was found to reside in the C terminus of the protein, because constructs from which the C-terminal StAR homology domain was deleted had no steroidogenic activity. In contrast, removal of N-terminal sequences increased MLN64's steroidogenesis-enhancing activity. MLN64 mRNA was found in many human tissues, including the placenta and brain, which synthesize steroid hormones but do not express StAR. Western blot analysis revealed the presence of lower molecular weight immunoreactive MLN64 species that contain the C-terminal sequences in human tissues. Homologs of both MLN64 and StAR were identified in Caenorhabditis elegans, indicating that the two proteins are ancient. Mutations that inactivate StAR were correlated with amino acid residues that are identical or similar among StAR and MLN64, indicating that conserved motifs are important for steroidogenic activity. We conclude that MLN64 stimulates steroidogenesis by virtue of its homology to StAR.
High-Resolution Scanning Coded-Mask-Based X-ray Multi-Contrast Imaging and Tomography (2021)

Near-field X-ray speckle tracking has been used in phase-contrast imaging and tomography as an emerging technique, providing higher contrast images than traditional absorption radiography. Most reported methods use sandpaper or membrane filters as speckle generators and digital image cross-correlation for phase reconstruction, which has either limited resolution or requires a large number of position scanning steps. Recently, we have proposed a novel coded-mask-based multi-contrast imaging (CMMI) technique for single-shot measurement with superior performance in efficiency and resolution compared with other single-shot methods. We present here a scanning CMMI method for the ultimate imaging resolution and phase sensitivity by using a coded mask as a high-contrast speckle generator, the flexible scanning mode, the adaption of advanced maximum-likelihood optimization to scanning data, and the multi-resolution analysis. Scanning CMMI can outperform other speckle-based imaging methods, such as X-ray speckle vector tracking, providing higher quality absorption, phase, and dark-field images with fewer scanning steps. Scanning CMMI is also successfully demonstrated in multi-contrast tomography, showing great potentials in high-resolution full-field imaging applications, such as in vivo biomedical imaging.
Nitrogen-doped carbon nanotube sponge with embedded Fe/Fe<sub>3</sub>C nanoparticles as binder-free cathodes for high capacity lithium–sulfur batteries (2018)

A 3-dimensional N-doped CNT sponge with embedded Fe/Fe<sub>3</sub>C nanoparticles as flexible binder-free cathodes for high sulfur loading Li–S batteries.
Intact Size-Selected Au<i><sub>n</sub></i> Clusters on a TiO<sub>2</sub>(110)-(1 × 1) Surface at Room Temperature (2005)

Experiments in which mass-selected gold clusters were deposited on a surface have found that the catalytic properties depend strongly on cluster size. However, these experiments have not established definitively that the clusters maintain their size after deposition. We report here work in which we deposit low kinetic energy, mass-selected Aun+ (n = 1-8) clusters on a rutile TiO2(1 x 1) surface and use ultrahigh vacuum scanning tunneling microscopy (UHV-STM) to determine their size and shape.
Photobiocatalytic decarboxylation for olefin synthesis (2014)

Here, we describe the combination of OleTJE with a light-driven in situ H2O2-generation system for the selective and quantitative conversion of fatty acids into terminal alkenes. The photobiocatalytic system shows clear advantages regarding enzyme activity and yield, resulting in a simple and efficient system for fatty acid decarboxylation.
Three Novel Terpenoids from <i>Schisandra pubescens</i> var. <i>pubinervis</i> (2006)

Abstract Three new terpenoids, pubinernoids A–C ( 1 – 3 ), together with six known sesquiterpenoids, were isolated from the leaves and stems of Schisandra pubescens var. pubinervis. The structures of the new compounds were established on the basis of extensive spectroscopic analyses, including application of 2D‐NMR spectroscopic techniques. A plausible formation of the sesquiterpenoid 2 is proposed ( Scheme 2 ), starting from guaianediol ( 4 ) as the biogenetic precursor, which was also present in the extract.
Real Men Do JavaScript! Programming the World in a Browser. (2008)

JavaScript is the most widely used dynamic language in the world and is becoming increasingly important as an application programming language. While many hard core developers are still in denial, Web 2.0 application developers from small and large companies are developing increasingly complex applications that run close to the user.
Dimensions of Hybrid in Playful Products (2013)

In this article we examine playful hybrid products located in the intersection of toys and games. By hybrid, we mean games and toys that utilize digital environments to provide added value to tactile, physical or material experiences. The paper aims to create a preliminary model for mapping hybrid dimensions. Our initial analysis paints a picture of a design space with varied degrees of hybridity. Comparing seven example cases lets us see how in some products the digital part of the experience is independent of the material side, while sometimes these sides are co-dependent. Further, in some cases the digital and material halves are intertwined to a synchronous experience, whereas in others they take turns. Our analysis is preliminary at this point and we conclude that there is much room for future research in the field of hybrid play products.
Genomic assays for Epstein–Barr virus-positive gastric adenocarcinoma (2015)

A small set of gastric adenocarcinomas (9%) harbor Epstein-Barr virus (EBV) DNA within malignant cells, and the virus is not an innocent bystander but rather is intimately linked to pathogenesis and tumor maintenance. Evidence comes from unique genomic features of host DNA, mRNA, microRNA and CpG methylation profiles as revealed by recent comprehensive genomic analysis by The Cancer Genome Atlas Network. Their data show that gastric cancer is not one disease but rather comprises four major classes: EBV-positive, microsatellite instability (MSI), genomically stable and chromosome instability. The EBV-positive class has even more marked CpG methylation than does the MSI class, and viral cancers have a unique pattern of methylation linked to the downregulation of CDKN2A (p16) but not MLH1. EBV-positive cancers often have mutated PIK3CA and ARID1A and an amplified 9p24.1 locus linked to overexpression of JAK2, CD274 (PD-L1) and PDCD1LG2 (PD-L2). Multiple noncoding viral RNAs are highly expressed. Patients who fail standard therapy may qualify for enrollment in clinical trials targeting cancer-related human gene pathways or promoting destruction of infected cells through lytic induction of EBV genes. Genomic tests such as the GastroGenus Gastric Cancer Classifier are available to identify actionable variants in formalin-fixed cancer tissue of affected patients.
Identification, annotation of Mucin genes in channel catfish<i>(Ictalurus punctatus)</i>and their expression after bacterial infections revealed by RNA‐Seq analysis (2020)

Mucins are large glycoproteins that cover epithelial surfaces of the body and play important roles in prevention of inflammatory and various infectious diseases. In this study, five membrane-bound and seven secreted mucin genes in the channel catfish were identified. All these identified mucin genes possess at least one PTS, von Willebrand D (VWD) or SEA domains. The expression of the 12 mucin genes in channel catfish was first studied with infection of Edwardsiella ictaluri and Flavobacterium columnare. Expression difference in MUC13a, MUC13, MUC2 and MUC5b was found in the intestine after E. ictaluri infection. Eight mucin gene expressions (except MUC3a, MUC2, MUC4 and MUC5f) were up-regulated at 4 hr and down-regulated after 24 hr in the gill with F. columnare infection. Expression level of MUC2 gene was up-regulated in the intestine with E. ictaluri infection without no significant change in the gill under the F. columnare infection, which indicate that MUC2 is tissue-specific gene expression and has different immune respond to two bacterial challenge. Taken together, the study showed mucin from the gill by F. columnare challenge induced an obvious response than mucin from the intestine with E. ictaluri infection.
Synthesis of 2',3'-dideoxyuridine via deoxygenation of 2',3'-O-(methoxymethylene)uridine (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2',3'-dideoxyuridine via deoxygenation of 2',3'-O-(methoxymethylene)uridineHiroshi Shiragami, Yasuo Irie, Hideyuki Shirae, Kenzo Yokozeki, and Naohiko YasudaCite this: J. Org. Chem. 1988, 53, 21, 5170–5173Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/jo00256a056https://doi.org/10.1021/jo00256a056research-articleACS PublicationsRequest reuse permissionsArticle Views492Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vitamin D Induction of the Human Antimicrobial Peptide Cathelicidin in the Urinary Bladder (2010)

The urinary tract is frequently being exposed to potential pathogens and rapid defence mechanisms are therefore needed. Cathelicidin, a human antimicrobial peptide is expressed and secreted by bladder epithelial cells and protects the urinary tract from infection. Here we show that vitamin D can induce cathelicidin in the urinary bladder. We analyzed bladder tissue from postmenopausal women for expression of cathelicidin, before and after a three-month period of supplementation with 25-hydroxyvitamin D3 (25D3). Cell culture experiments were performed to elucidate the mechanisms for cathelicidin induction. We observed that, vitamin D per se did not up-regulate cathelicidin in serum or in bladder tissue of the women in this study. However, when the bladder biopsies were infected with uropathogenic E. coli (UPEC), a significant increase in cathelicidin expression was observed after 25D3 supplementation. This observation was confirmed in human bladder cell lines, even though here, cathelicidin induction occurred irrespectively of infection. Vitamin D treated bladder cells exerted an increased antibacterial effect against UPEC and colocalization to cathelicidin indicated the relevance of this peptide. In the light of the rapidly growing problem of resistance to common urinary tract antibiotics, we suggest that vitamin D may be a potential complement in the prevention of UTI.
Graphical multiscale Web histories (1998)

We have implemented a browser companion called PadPrints that dynamically builds a graphical history-map of visited web pages. PadPrints relies on Pad++, a zooming user interface (ZUI) development substrate, to display the history-map using minimal screen space. PadPrints functions in conjunction with a traditional web browser but without requiring any browser modifications. We performed two usability studies of PadPrints. The first addressed general navigation effectiveness. The second focused on history-relat ed aspects of navigation. In tasks requiring returns to prior pages, users of PadPrints completed tasks in 61.2% of the time required by users of the same browser without PadPrints. We also observed significant decreases in the number of pages accessed when using PadPrints. Users found browsing with PadPrints more satisfying than using Netscape alone.
Toward the clinical application of time-domain fluorescence lifetime imaging (2005)

High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The optimization and potential application of FLIM to tissue autofluorescence for clinical applications are discussed.
Analysis of the Key Agreement Scheme of ZigBee Standard (2010)

With the rapid development of electronics and wireless communications technology, wireless sensor networks consisting of many wireless sensors can he used for various application fields such as military, chemical, business. Since most wireless sensor network applications have strict security requirements, security is a critical issue in wireless sensor networks. However, the new ZigBee has the security in networks formation. This paper completely analyzes ZigBee security structure, key agreement scheme. At last, presents the test vectors.
Control of Electron Transport in Photosystem I by the Iron-Sulfur Cluster FX in Response to Intra- and Intersubunit Interactions (2003)

Photosystem I (PS I) is a transmembranal multisubunit complex that mediates light-induced electron transfer from plactocyanine to ferredoxin. The electron transfer proceeds from an excited chlorophyll a dimer (P700) through a chlorophyll a (A0), a phylloquinone (A1), and a [4Fe-4S] iron-sulfur cluster FX, all located on the core subunits PsaA and PsaB, to iron-sulfur clusters FA and FB, located on subunit PsaC. Earlier, it was attempted to determine the function of FX in the absence of FA/B mainly by chemical dissociation of subunit PsaC. However, not all PsaC subunits could be removed from the PS I preparations by this procedure without partially damaging FX. We therefore removed subunit PsaC by interruption of the psaC2 gene of PS I in the cyanobacterium Synechocystis sp. PCC 6803. Cells could not grow under photosynthetic conditions when subunit PsaC was deleted, yet the PsaC-deficient mutant cells grew under heterotrophic conditions and assembled the core subunits of PS I in which light-induced electron transfer from P700 to A1 occurred. The photoreduction of FX was largely inhibited, as seen from direct measurement of the extent of electron transfer from A1 to FX. From the crystal structure it can be seen that the removal of subunits PsaC, PsaD, and PsaE in the PsaC-deficient mutant resulted in the braking of salt bridges between these subunits and PsaB and PsaA and the formation of a net of two negative surface charges on PsaA/B. The potential induced on FX by these surface charges is proposed to inhibit electron transport from the quinone. In the complete PS I complex, replacement of a cysteine ligand of FX by serine in site-directed mutation C565S/D566E in subunit PsaB caused an approximately 10-fold slow down of electron transfer from the quinone to FX without much affecting the extent of this electron transfer compared with wild type. Based on these and other results, we propose that FX might have a major role in controlling electron transfer through PS I.
Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. (1997)

Human papilloma virus 16 (HPV 16) is associated with cervical cancer and is therefore considered a major health risk for women. Immortalization of keratinocytes induced by HPV infection is largely due to the binding of p53 and Rb by the the viral oncoproteins E6 and E7, respectively, and is driven to a large extent by a transforming growth factor alpha/amphiregulin epidermal growth factor receptor autocrine loop. In this study, we show that the growth of HPV 16-immortalized human keratinocytes can be blocked by a selective epidermal growth factor receptor kinase inhibitor, AG 1478, and by AG 555, a blocker of cyclin-dependent kinase 2 (Cdk2) activation. AG 1478 induces a massive increase in the Cdk2 protein inhibitors p27 and p21, whereas AG 555 appears to have a different mechanism of action, inhibiting the activation of Cdk2. Growth arrest induced by AG 1478 and AG 555 is accompanied by up to 20% of cells undergoing apoptosis. Following AG 1478 treatment but not AG 555 treatment, up to 50% of cells undergo terminal keratinocyte differentiation as determined by filaggrin expression and by the decline in the expression of cytokeratin 14. The growth-arresting properties of AG 1478 and AG 555 identifies them as possible lead antipapilloma agents.