gebhart/patrepeval huggingface dataset:
Lightweight eye capture using a parametric model (2016)

Facial scanning has become ubiquitous in digital media, but so far most efforts have focused on reconstructing the skin. Eye reconstruction, on the other hand, has received only little attention, and the current state-of-the-art method is cumbersome for the actor, time-consuming, and requires carefully setup and calibrated hardware. These constraints currently make eye capture impractical for general use. We present the first approach for high-quality lightweight eye capture, which leverages a database of pre-captured eyes to guide the reconstruction of new eyes from much less constrained inputs, such as traditional single-shot face scanners or even a single photo from the internet. This is accomplished with a new parametric model of the eye built from the database, and a novel image-based model fitting algorithm. Our method provides both automatic reconstructions of real eyes, as well as artistic control over the parameters to generate user-specific eyes.
Prostate specific antigen and androgen receptor induction and characterization of an immortalized adult human prostatic epithelial cell line (1996)

Progress in prostate cancer research has been hindered by the lack of well characterized, immortalized, human prostatic epithelial cell lines that express markers of normal prostatic epithelial cells and mimic normal growth and differentiation responses to androgens. The objectives of this study were to: (i) establish immortalized cell lines from non-neoplastic, adult human prostatic epithelium using adenovirus-12/simian virus-40 (Ad12-SV40) hybrid virus; (ii) establish their prostatic epithelial origin; (iii) demonstrate androgen responsiveness; and (iv) examine response to growth factors. Primary epithelial cell cultures derived from a non-neoplastic, adult human prostate were infected with the Ad12-SV40 virus. Several immortalized clones were isolated. Single cell cloning of one clone, free of cytopathic effects, gave rise to the PWr-1E cell line. An immortalized cell line PWR-1E, which expresses many characteristics of normal prostatic epithelial cells was established. Immunostaining showed that cells express cytokeratins 8 and 18 normally expressed by differentiated, secretory prostatic epithelial cells. The most remarkable characteristics of PWR-1E cells are growth stimulation, increased expression of androgen receptor and induction of prostate specific antigen (PSA) expression in response to androgens, which indisputably establish their prostatic epithelial origin. They are positive for SV40 large-T antigen and show strong nuclear staining for p53. Cells from passages 23 and 40 were not tumorigenic in nude mice even when co-injected with Matrigel. They grow in a serum-free defined medium and respond to EGF, bFGF and TGF-beta. Passage 42-cells showed a human male (XY), hyperdiploid karyotype. The PWR-1E cell line is the only known Ad12-SV40-immortalized human prostatic epithelial cell line. PWR-1E cells can be used to study (i) the etiology and the multistep process of carcinogenesis and tumor progression in the human prostate; (ii) normal prostate physiology and differentiation; and (iii) potential prostate cancer chemopreventive agents.
Accommodating Rectangular Objects in Probability Calculations (2004)

This work refines probability calculations for rectangular object shapes of unknown orientation and compares those results to their representations as spheres. Conjunction probability analysis for spherical objects exhibiting linear relative motion is accomplished by combining covariances and physical object dimensions at the point of closest approach. The resulting covariance ellipsoid and hardbody can then be projected onto the plane perpendicular to relative velocity. Collision potential is determined from the object's physical footprint on the projected, two-dimensional, probability density space. For rectangular objects, the attitude must be considered because the region of integration (footprint) changes. Ideally, the attitude of each object should be known to accurately assess this probability. In the absence of object attitude information, a footprint must be created that completely defines the region where the two objects might touch. This footprint can then be rotated to determine the orientation that produces the largest probability making it the most conservative estimate for the given conjunction conditions. For a rectangular object modeled as a circle, the representation is shown to be overly conservative, producing a larger probability than that of the rectangular shape.
Antitumor Effects of EGFR Antisense Guanidine-Based Peptide Nucleic Acids in Cancer Models (2012)

Peptide nucleic acids have emerged over the past two decades as a promising class of nucleic acid mimics because of their strong binding affinity and sequence selectivity toward DNA and RNA, and resistance to enzymatic degradation by proteases and nucleases. While they have been shown to be effective in regulation of gene expression in vitro, and to a small extent in vivo, their full potential for molecular therapy has not yet been fully realized due to poor cellular uptake. Herein, we report the development of cell-permeable, guanidine-based peptide nucleic acids targeting the epidermal growth factor receptor (EGFR) in preclinical models as therapeutic modality for head and neck squamous cell carcinoma (HNSCC) and nonsmall cell lung cancer (NSCLC). A GPNA oligomer, 16 nucleotides in length, designed to bind to EGFR gene transcript elicited potent antisense effects in HNSCC and NSCLC cells in preclinical models. When administered intraperitoneally in mice, EGFRAS-GPNA was taken-up by several tissues including the xenograft tumor. Systemic administration of EGFRAS-GPNA induced antitumor effects in HNSCC xenografts, with similar efficacies as the FDA-approved EGFR inhibitors: cetuximab and erlotinib. In addition to targeting wild-type EGFR, EGFRAS-GPNA is effective against the constitutively active EGFR vIII mutant implicated in cetuximab resistance. Our data reveals that GPNA is just as effective as a molecular platform for treating cetuximab resistant cells, demonstrating its utility in the treatment of cancer.
Immunomodulation In Vivo by the Mycoplasma arthritidis Superantigen, MAM (1993)

Mycoplasma arthritidis produces a potent superantigen (MAM) that activates specific murine and human T lymphocytes to proliferate and secrete lymphokines. We show here that MAM also influences both T- and B-cell functions in vivo. Lymphocytes from mice injected with MAM exhibit a suppression of proliferative responses to MAM in vitro but only a partial suppression of responses to other mitogens. This T-cell anergy not only decreased contact sensitivity to dinitrofluorobenzene but also prolonged survival of skin transplants. In contrast, B-cell reactivity is increased following in vivo injection of MAM, as evidenced by enhanced antibody responses to sheep red blood cells and ovalbumin. Also, there is a marked decrease in the ability of splenocytes from MAM-injected mice to produce interleukin-2 (IL-2) but a marked increase in their ability to produce IL-4 and IL-6. The combined results suggest that MAM induces a lymphokine profile that favors activation of B-cell functions, with a resulting potential for triggering of autoimmune disease.
Synthesis of Poly(ester‐anhydrides) Based on Different Polyester Precursors (2004)

Abstract Summary: Poly(ester‐anhydrides) were synthesised from poly( L ‐lactide), poly( D , L ‐lactide), and poly( ε ‐caprolactone) prepolymers prepared by ring‐opening polymerisation of cyclic esters in the presence of 1,4‐butanediol or ricinoleic acid as co‐initiator. The hydroxyl group end functionality of the prepolymers was converted to carboxylic acid functionality by reaction with succinic anhydride, and the polyester precursors were coupled by melt polycondensation to give poly(ester‐anhydrides). 1,4‐Butanediol was used as co‐initiator to study the properties of poly(ester‐anhydrides) prepared from different monomers, whereas ricinoleic acid was used as co‐initiator to introduce a hydrophobic fatty acid moiety to the polyester precursor. In hydrolysis tests, the poly(ester‐anhydrides) showed a two‐stage degradation comprising a rapid hydrolysis of anhydride linkages within three days, followed by the slower hydrolysis of the remaining polyester oligomer. Weight loss of the poly(ester‐anhydrides) depended most importantly on molecular weight and thermal properties of the polyester precursors; thus, poly(ester‐anhydrides) prepared from low molecular weight prepolymers having thermal transitions below 37 °C showed very fast weight loss. image
Transformation of seismic velocity data to extract porosity and saturation values for rocks (2000)

For wave propagation at low frequencies in a porous medium, the Gassmann-Domenico relations are well-established for homogeneous partial saturation by a liquid. They provide the correct relations for seismic velocities in terms of constituent bulk and shear moduli, solid and fluid densities, porosity and saturation. It has not been possible, however, to invert these relations easily to determine porosity and saturation when the seismic velocities are known. Also, the state (or distribution) of saturation, i.e., whether or not liquid and gas are homogeneously mixed in the pore space, is another important variable for reservoir evaluation. A reliable ability to determine the state of saturation from velocity data continues to be problematic. It is shown how transforming compressional and shear wave velocity data to the (rho/lambda, mu/lambda)-plane (where lambda and mu are the Lame parameters and rho is the total density) results in a set of quasi-orthogonal coordinates for porosity and liquid saturation that greatly aids in the interpretation of seismic data for the physical parameters of most interest. A second transformation of the same data then permits isolation of the liquid saturation value, and also provides some direct information about the state of saturation. By thus replotting the data in the (lambda/mu, rho/mu)-plane, inferences can be made concerning the degree of patchy (inhomogeneous) versus homogeneous saturation that is present in the region of the medium sampled by the data. Our examples include igneous and sedimentary rocks, as well as man-made porous materials. These results have potential applications in various areas of interest, including petroleum exploration and reservoir characterization, geothermal resource evaluation, environmental restoration monitoring, and geotechnical site characterization.
A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins (1997)

Two small fragments of a novel human gammaherpesvirus genome known as Kaposi's sarcoma (KS)-associated herpesvirus or human herpesvirus 8 (HHV-8) have been shown to be present in virtually all AIDS and non-AIDS KS lesions, as well as in body cavity-based lymphomas (BCBL) and in multicentric Castleman's disease. We have extended those studies by identifying and sequencing a third fragment of HHV-8 DNA encoding a viral thymidylate synthetase (TS) gene. Use of this viral TS fragment as a probe led to the identification and mapping of a cluster of overlapping phage lambda clones from a BCBL tumor DNA genomic library that spanned 48 kb on the left-hand side of the HHV-8 genome between the equivalents of open reading frame 6 (ORF6) and ORF31 of herpesvirus saimiri (HVS). DNA sequencing of a 17-kb segment encompassing a gammaherpesvirus divergent locus (DL-B) between ORF11 and ORF17 revealed the presence of nine viral ORFs with predicted gene products related to cellular proteins. These include the complete TS gene and a dihydrofolate reductase (DHFR) gene, four novel cytokine genes (encoding viral interleukin-6, viral MIP-1A, viral MIP-1B, and BCK) that have not previously been found to be encoded by a virus, and a bcl-2 homolog. This region in HHV-8 also contains the T1.1 abundant lytic cycle nuclear RNA gene and encompasses two genes (or exons) encoding proteins with C4HC3 zinc finger domains of the PHD/leukemia-associated protein subtype. The latter are related to the spliced immediate-early IE1 protein of the gamma-2 class herpesvirus bovine herpesvirus type 4 and a similar motif found in HVS ORF12. Although genes for TS and DHFR enzymes are also encoded by HVS (ORF70 and ORF2), both occur at different genomic loci than in HHV-8, and the HHV-8 DHFR protein is much farther diverged from human DHFR than is the HVS version, implying that they were probably acquired as host cell cDNAs by independent evolutionary events. Transcripts from the IE1-A, IE1-B, DHFR, and MIP-1B genes were all detected by Northern blot hybridization analysis in a BCBL cell line at 12 h after induction with butyrate but were not present before induction, indicating that these are all primarily lytic cycle genes. We conclude that the DL-B locus of gammaherpesviruses displays considerably more variability that previously appreciated and that expression of many of these genes is likely to have important implications for HHV-8 biology and therapy.
Cyclic Alkyl Amino Carbene (CAAC) Ruthenium Complexes as Remarkably Active Catalysts for Ethenolysis (2014)

Abstract An expanded family of ruthenium‐based metathesis catalysts bearing cyclic alkyl amino carbene (CAAC) ligands was prepared. These catalysts exhibited exceptional activity in the ethenolysis of the seed‐oil derivative methyl oleate. In many cases, catalyst turnover numbers (TONs) of more than 100 000 were achieved, at a catalyst loading of only 3 ppm. Remarkably, the most active catalyst system was able to achieve a TON of 340 000, at a catalyst loading of only 1 ppm. This is the first time a series of metathesis catalysts has exhibited such high performance in cross‐metathesis reactions employing ethylene gas, with activities sufficient to render ethenolysis applicable to the industrial‐scale production of linear α‐olefins (LAOs) and other terminal‐olefin products.
Temporal coupled-mode theory model for resonant near-field thermophotovoltaics (2015)

A temporal Coupled-Mode Theory model is developed to predict performance of resonant near-field ThermoPhotoVoltaic systems, which typically requires numerically intensive calculations. It is formulated for both orthogonal and non-orthogonal (coupled) modes and includes load-voltage dependencies and non-idealities, such as background absorption and radiation losses. Its good accuracy is confirmed by comparing with exact transfer-matrix calculations for two simple planar systems: a plasmonic emitter across a bulk semiconductor absorber and a metal-backed thin-film semiconductor emitter across an identical absorber.
The bcr gene in Philadelphia chromosome positive acute lymphoblastic leukemia (1989)

Abstract In chronic myelogenous leukemia (CML) and in a percentage of childhood and adult acute lymphoblastic leukemia (ALL) the Philadelphia (Ph′) chromosome is present in the leukemic cells of patients. This chromosome is the result of a reciprocal translocation between chromosomes 9 and 22. In CML the break on chromosome 22 occurs within the major breakpoint cluster region (Mbcr) of the bcr gene. In this study, we report on the examination of DNAs from nine Ph′-chromosome positive ALL patients for rearrangements within the bcr gene using Southern blot analysis. Of nine patients having a karyotypically identifiable Ph′-chromosome, only five exhibited rearrangements of the bcr gene. This could indicate that in ALL, chromosome 22 sequences other than the bcr gene are involved in the Ph′-translocation. Within the group of Ph′-positive ALL patients having a bcr gene breakpoint, a correlation appears to exist between the age of the patient and the location of the breakpoint within the gene: all or the vast majority of pediatric patients analyzed to date do not have a Mbcr breakpoint as found in CML and in adult ALL.
A computationally efficient method for tracking reference position displacements for motion compensation in magnetic resonance imaging (1999)

A fast and computationally efficient method for detecting and tracking the displacement of a reference structure within the body using MR imaging is described. This method is used to determine the position of the diaphragm in order to synchronize the data acquisition to the same relative position of the abdominal and thoracic organs, thereby minimizing or eliminating respiratory motion artifacts. The method described uses the time domain linear phase shift of a reference structure to determine its spatial positional displacement as a function of the respiratory cycle. The signal from a two-dimensional rectangular excitation column is first Fourier-transformed to the image domain, apodized, and then transformed back to the time domain. The relative displacement of a target edge in the image domain is determined from an autocorrelation of the resulting time domain information. This technique was found to require between three and eight times less computation than either cross-correlation or least-squares analysis, depending on the navigator parameters. Magn Reson Med 42:548–553, 1999. © 1999 Wiley-Liss, Inc.
Synthesis of an Ammonium Ionophore and Its Application in a Planar Ion-Selective Electrode (2002)

A modular technique was used to synthesize an ammonium-selective ionophore based on a cyclic depsipeptide structure. The ionophore was incorporated into a planar ion-selective electrode sensor format and the selectivity tested versus a range of metal cations in a commercial clinical diagnostic "point-of-care" instrument. Four sensor membrane formulations were tested, all of which consisted of plasticized PVC. Formulations differed as to the type of plasticizer used and whether an ionic additive was present. It was found that the membrane containing the polar plasticizer nitrophenyl octyl ether in the absence of ionic additive exhibited near-Nernstian behavior (slope, 60.1 mV/decade at 37 degrees C) and possessed high selectivity for ammonium ion over lithium and the divalent cations, calcium and magnesium (log K(POT)NH4+(j) = -7.3, -4.4, and -7.1 for lithium, calcium, and magnesium ions, respectively). The same membrane also exhibited sodium and potassium selectivity that was comparable to that reported for nonactin (log K(POT)NH4+(j) = -2.1 and -0.6 for sodium and potassium, respectively, compared to -2.4 and -0.9 in the case of nonactin). Membranes containing the less polar plasticizer, dioctyl phthalate, showed sub-Nernstian behavior (slope, <50 mV/decade at 37 degrees C). In all cases, the presence of the ionic additive potassium tetrakis(4-chlorophenyl)borate substantially reduced the selectivity observed. The flexible modular synthetic technique developed and reported here will allow the cyclic depsipeptide structure to be tuned for optimum selectivity.
Advanced Hyperspectral and X-Ray Fluorescence Sensors for Monitoring Contaminated Soils (2018)

Environmental hazards such as accidental petroleum spillage and heavy metal contamination can be effectively managed by rapid, non-invasive characterization of environmental samples in conjunction with spatial variability mapping using several geostatistical interpolation techniques like ordinary kriging and indicator kriging. This chapter outlines the uses of two soil proximal sensors – portable x-ray fluorescence spectrometry (PXRF) and hyperspectral visible near infrared diffuse reflectance spectroscopy (VisNIR DRS) for rapid characterization of soil contamination. Basic principles of PXRF and VisNIR DRS have been discussed and specific case studies were included to justify their feasibility.
<title>The distributed Brillouin sensor system based on offset locking two DFB lasers</title> (2007)

In this paper, we demonstrated a distributed Brillouin sensor based on the offset locking of two 1550nm DFB lasers. We use PID controller and optical delay line to lock and tune the frequency difference between two DFB lasers and we also use lock in amplifier to stabilize the DC level of the EOM. The power depletion in the Brillouin scattering has been studied to show optimized strain and temperature accuracy. With this sensor system, we can get the spatial resolution which is 1m with temperature resolution of < 1°C.
Reduction of myocardial damage by prolonged treatment with subcutaneous low molecular weight heparin in unstable coronary artery disease (1999)

Long-term subcutaneous treatment with low molecular weight heparin decreases the number of subsequent myocardial infarctions - determined both conventionally and by an increase in QRS score - in patients with unstable coronary artery disease. Silent myocardial infarctions detected by QRS score, as well as clinical myocardial infarctions, could be used as end-points in clinical trials of ischaemic heart disease and thus lower the population needed for obtaining statistical power.
Camera based evaluation of photometric compensation methods on multi-projector displays (2005)

An important problem in achieving seamless multi-projector displays is the photometric (luminance) variation across the display. Currently, evaluation of the improvement in the quality of the imagery achieved by applying different photometric correction methods and a comparison between them is done by a subjective human user. In this paper, we present a camera-based method for relative evaluation of the luminance properties of the imagery on multi-projector displays, both before correction and after correction using different compensation techniques. To the best of our knowledge, this is the first camera-based method designed to evaluate the different photometric correction methods on a multi-projector display. We show that using our simple and automatic evaluation scheme the optimal photometric compensation parameter for a multi-projector display can be identified, which is not possible by subjective evaluation.
Machine-based Multimodal Pain Assessment Tool for Infants: A Review (2016)

Bedside caregivers assess infants' pain at constant intervals by observing specific behavioral and physiological signs of pain. This standard has two main limitations. The first limitation is the intermittent assessment of pain, which might lead to missing pain when the infants are left unattended. Second, it is inconsistent since it depends on the observer's subjective judgment and differs between observers. The intermittent and inconsistent assessment can induce poor treatment and, therefore, cause serious long-term consequences. To mitigate these limitations, the current standard can be augmented by an automated system that monitors infants continuously and provides quantitative and consistent assessment of pain. Several automated methods have been introduced to assess infants' pain automatically based on analysis of behavioral or physiological pain indicators. This paper comprehensively reviews the automated approaches (i.e., approaches to feature extraction) for analyzing infants' pain and the current efforts in automatic pain recognition. In addition, it reviews the databases available to the research community and discusses the current limitations of the automated pain assessment.