gebhart/patrepeval huggingface dataset:
High Electron Mobility in Solution-Cast and Vapor-Deposited Phenacyl−Quaterthiophene-Based Field-Effect Transistors:  Toward N-Type Polythiophenes (2005)

New carbonyl-functionalized quaterthiophenes, 5,5' ''-diperfluorophenylcarbonyl-2,2':5',2' ':5' ',2' ''-quaterthiophene [DFCO-4T], 5,5' ''-diphenyl-2,2':5',2' ':5' ',2' ''-quaterthiophene [DPCO-4T], and a polymer having the same basic motif as DFCO-4T, poly{1,4-bis[(3'-n-octyl-2,2'-dithiophene)carbonyl]-2,3,5,6-tetrafluorobenzene} [P(COFCO-4T)], have been synthesized, characterized, and the crystal structures of the molecules determined. Field-effect transistors fabricated with vapor-deposited and solution-cast films of DFCO-4T exhibit very high Ion:Ioff current ratios (up to 108) and electron mobilities up to approximately 0.51 and approximately 0.25 cm2.V-1.s-1, respectively. Solution-cast blends of P(COFCO-4T) and DFCO-4T (1:1 weight ratio) exhibit an electron mobility of approximately 0.01 cm2.V-1.s-1 (Ion:Ioff = 104).
Improved Raoultella planticola Strains for the Production of 2,3-Butanediol from Glycerol (2019)

Raw glycerol is an industrial byproduct from biodiesel production and is one of the most promising substrates for 2,3-butanediol (2,3-BD) production; however, 2,3-BD is not yet produced by fermentation from glycerol on a commercial scale due to poor process economics. Class 1 microorganism collections were screened and Raoultella planticola strain CECT 843 proved to be the best 2,3-BD producer, achieving (23.3 ± 1.4) g 2,3-BD per L and a yield of 36% (g 2,3-BD per g glycerol). To further increase product concentration and yield, R. planticola CEC T843 was subjected to random mutagenesis using ultra-violet (UV) light and ethyl methane sulfonate (EMS). Two mutant strains were found to produce at least 30% more 2,3-BD than the wild type: R. planticola IA1 [(30.8 ± 3.9) g 2,3-BD per L and 49% yield] and R. planticola IIIA3 [(30.5 ± 0.4) g 2,3-BD per L and 49% yield].
Engineered Warp Knit Auxetic Fabrics (2012)

Composite materials: It has been suggested When an auxetic fiber is pulled, it will expand and effectively lock into the matrix rather than contracting and pulling out easily as a conventional fiber would do. Thus, auxetic materials can be used in a diverse range of applications, including as core materials in curved sandwich panel composite components, directional pass band filters, Micro-Electro-Mechanical Systems (MEMS) devices, filters and sieves, seat cushion
Stochastic demand charge management for commercial and industrial buildings (2017)

In this paper, we propose a strategy for battery operation to manage monthly peak electricity demand of commercial & industrial buildings and reduce the associated Demand Charges (DC) in their utility bills. In specific, we present a stochastic optimization model that calculates the monthly Demand Charge Thresholds (DCT) at month-ahead. During the month, the battery charges and discharges according to DCT and measured demand at each time step. We apply techniques that convert the rule-based control algorithm into linear constraints and incorporate them in the model. Case studies suggest that, compared with other methods, the stochastic method generates DCTs closer to their expected value and achieves higher Demand Charge (DC) savings.
Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3) (1997)

Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous subtype of non-insulin-dependent diabetes mellitus (NIDDM) characterised by early onset, autosomal dominant inheritance and a primary defect in insulin secretion. Recent studies have shown that mutations in the two functionally related transcription factors, hepatocyte nuclear factor 4 alpha (HNF-4alpha) and hepatocyte nuclear factor 1 alpha (HNF-1alpha) are associated with the MODY1 and MODY3 forms of diabetes respectively, whereas mutations in the enzyme glucokinase are the cause of the MODY2 form. We have examined 10 unrelated Caucasian families in which MODY/NIDDM co-segregated with markers for MODY3 for mutations in the HNF-1alpha gene (TCF1). Ten different mutations were observed in these families, all of which co-segregated with diabetes. There were no obvious relationships between the nature of the mutations observed (i.e. frameshift, nonsense, or missense) or their location in the gene with clinical features of diabetes (age at onset, severity) in these families. The mechanisms by which mutations in the HNF-1alpha gene cause diabetes mellitus are unclear but might include abnormal pancreatic islet development during foetal life thereby limiting their later function, as well as impaired transcriptional regulation of genes that play a key role in normal pancreatic beta cell function.
A Biomechanical Model for Actively Controlled Snow Ski Bindings (1980)

Active control of snow ski bindings is a new design concept which potentially offers improved protection from lower extremity injury. Implementation of this concept entails measuring physical variables and calculating loading and/or deformation in injury prone musculoskeletal components. The subject of this paper is definition of a biomechanical model for calculating tibia torsion based on measurements of torsion loading between the boot and ski. Previous control schemes have used leg displacement only to indicate tibia torsion. The contributions of both inertial and velocity-dependent torques to tibia loading are explored and it is shown that both these moments must be included in addition to displacement-dependent moments. A new analog controller design which includes inertia, damping, and stiffness terms in the tibia load calculation is also presented.
A monolithic spiral transmission-line balun (2002)

We describe models and a design method for a circular spiral transmission-line balun and compare these with the measured results. The balun is fabricated using silicon thin-film MCM-D technology, and is suitable for integration in RF packages. It has a wide bandwidth and provides excellent balanced outputs in the frequency range of 1.6/spl sim/3.2 GHz.
A Novel Shadow-Free Feature Extractor for Real-Time Road Detection (2016)

Road detection is one of the most important research areas in driver assistance and automated driving field. However, the performance of existing methods is still unsatisfactory, especially in severe shadow conditions. To overcome those difficulties, first we propose a novel shadow-free feature extractor based on the color distribution of road surface pixels. Then we present a road detection framework based on the extractor, whose performance is more accurate and robust than that of existing extractors. Also, the proposed framework has much low-complexity, which is suitable for usage in practical systems.
The Mutant Human ND4 Subunit of Complex I Induces Optic Neuropathy in the Mouse (2006)

Allotopic expression of the mutant human R340H ND4 subunit of complex I replicated the hallmarks of human mitochondrial disease in the mouse. In contrast, ocular expression of the wild-type human ND4 subunit in lower mammals appears safe, suggesting that it may be useful for treatment of patients with Leber hereditary optic neuropathy.
<title>High-resolution scintillator-based neutron imaging detector</title> (2001)

We describe a new high-resolution neutron-imaging detector. A neutron scintillator is imaged onto a photon-counting 2D imaging detector, with most of the scintillation used for event discrimination in this patented detector. Detection time and location are recorded, so neutron energy (time-of-flight) is measured for accelerator-based sources. We are currently fabricating a 25cmx25cm detector with 512x512 pixels and 100 ns time resolution. Results are presented for scintillator characterization measurements and imaging characteristics measured at IPNS, where the detector will reside.
Dyeable Cross-Linked Cellulose from Low Formaldehyde and Non-Formaldehyde Finishing Systems (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDyeable Cross-Linked Cellulose from Low Formaldehyde and Non-Formaldehyde Finishing SystemsEugene J. Blanchard, Robert M. Reinhardt, Elena E. Graves, and B. A. Kottes AndrewsCite this: Ind. Eng. Chem. Res. 1994, 33, 4, 1030–1034Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ie00028a034https://doi.org/10.1021/ie00028a034research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultrasonic Imaging Using Optoelectronic Transmitters (1998)

Conventional ultrasound scanners utilize electronic transmitters and receivers at the scanner with a separate coaxial cable connected to each transducer element in the handle. The number of transducer elements determines the size and weight of the transducer cable assembly that connects the imaging array to the scanner. 2-D arrays that allow new imaging modalities to be introduced significantly increase the channel count making the transducer cable assembly more difficult to handle. Therefore, reducing the size and increasing the flexibility of the transducer cable assembly is a concern. Fiber optics can be used to transmit signals optically and has distinct advantages over standard coaxial cable to increase flexibility and decrease the weight of the transducer cable for larger channel numbers. The use of fiber optics to connect the array and the scanner entails the use of optoelectronics such as detectors and laser diodes to send and receive signals. In transmit, optoelectronics would have to be designed to produce high-voltage wide-bandwidth pulses across the transducer element. In this paper, we describe a 48 channel ultrasound system having 16 optoelectronic transmitters and 32 conventional electronic receivers. We investigated both silicon avalanche photodiodes (APD's) and GaAs lateral photoconductive semiconductor switches (PCSS's) for producing the transmit pulses. A Siemens SI-1200 scanner and a 2.25 MHz linear array were used to compare the optoelectronic system to a conventional electronic transmit system. Transmit signal results and images in tissue mimicking of cysts and tumors are provided for comparison.
Familial Young-Onset Diabetes, Pre-Diabetes and Cardiovascular Disease Are Associated with Genetic Variants of DACH1 in Chinese (2014)

In Asia, young-onset type 2 diabetes (YOD) is characterized by obesity and increased risk for cardiovascular disease (CVD). In a genome-wide association study (GWAS) of 99 Chinese obese subjects with familial YOD diagnosed before 40-year-old and 101 controls, the T allele of rs1408888 in intron 1 of DACH1(Dachshund homolog 1) was associated with an odds ratio (OR) of 2.49(95% confidence intervals:1.57-3.96, P = 8.4 × 10(-5)). Amongst these subjects, we found reduced expression of DACH1 in peripheral blood mononuclear cells (PBMC) from 63 cases compared to 65 controls (P = 0.02). In a random cohort of 1468 cases and 1485 controls, amongst top 19 SNPs from GWAS, rs1408888 was associated with type 2 diabetes with a global P value of 0.0176 and confirmation in a multiethnic Asian case-control cohort (7370/7802) with an OR of 1.07(1.02-1.12, P(meta) = 0.012). In 599 Chinese non-diabetic subjects, rs1408888 was linearly associated with systolic blood pressure and insulin resistance. In a case-control cohort (n = 953/953), rs1408888 was associated with an OR of 1.54(1.07-2.22, P = 0.019) for CVD in type 2 diabetes. In an autopsy series of 173 non-diabetic cases, TT genotype of rs1408888 was associated with an OR of 3.31(1.19-9.19, P = 0.0214) and 3.27(1.25-11.07, P = 0.0184) for coronary heart disease (CHD) and coronary arteriosclerosis. Bioinformatics analysis revealed that rs1408888 lies within regulatory elements of DACH1 implicated in islet development and insulin secretion. The T allele of rs1408888 of DACH1 was associated with YOD, prediabetes and CVD in Chinese.
Knockout of Angiotensin AT2 receptors accelerates healing but impairs quality (2015)

Wounds are among the most common, painful, debilitating and costly conditions in older adults. Disruption of the angiotensin type 1 receptors (AT1R), has been associated with impaired wound healing, suggesting a critical role for AT1R in this repair process. Biological functions of angiotensin type 2 receptors (AT2R) are less studied. We investigated effects of genetically disrupting AT2R on rate and quality of wound healing. Our results suggest that AT2R effects on rate of wound closure depends on the phase of wound healing. We observed delayed healing during early phase of wound healing (inflammation). An accelerated healing rate was seen during later stages (proliferation and remodeling). By day 12, fifty percent of AT2R(-/-) mice had complete wound closure as compared to none in either C57/BL6 or AT1R(-/-) mice. There was a significant increase in AT1R, TGFβ1 and TGFβ2 expression during the proliferative and remodeling phases in AT2R(-/-) mice. Despite the accelerated closure rate, AT2R(-/-) mice had more fragile healed skin. Our results suggest that in the absence of AT2R, wound healing rate is accelerated, but yielded worse skin quality. Elucidating the contribution of both of the angiotensin receptors may help fine tune future intervention aimed at wound repair in older individuals.
hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. (1994)

It has recently been shown that hereditary nonpolyposis colorectal cancer (HNPCC) is caused by hereditable defects in DNA mismatch repair genes. However, the fraction of HNPCC due to defects in any one repair gene and the nature of these mutations are not known. We analyzed 29 HNPCC kindreds for mutations in the prototype DNA mismatch repair gene hMSH2 by a combination of linkage analysis, polymerase chain reaction-based screening, and sequencing of the coding region. The complete intron/exon structure of the gene was ascertained to facilitate this analysis. The results suggest that at least 40% of classic HNPCC kindreds are associated with germline mutations in hMSH2 and that most of these mutations produce drastic alterations in the predicted protein product.
Canine Interleukin-5: Molecular Characterization of the Gene and Expression of Biologically Active Recombinant Protein (2001)

Interleukin-5 (IL-5), which is produced primarily by type 2 T helper lymphocytes (Th2), is an eosinophil differentiation and activation factor. Increased numbers of eosinophils in peripherial blood or tissues (eosinophilia) are observed in asthmatic human patients, in animals with helminth infections, and in dogs with allergic diseases. Antagonism of IL-5 activity is being explored as a potential treatment of a number of disease conditions associated with eosinophils in animal models. In order to study the expression and function of this cytokine in the dog, we have isolated and characterized the canine IL-5 gene. The canine IL-5 polypeptide deduced from the cDNA is composed of 134 amino acids that share varying degrees of homology with IL-5 isolated from several mammals. The genomic structure of the canine IL-5 gene consists of four exons and three introns in the coding region, similar to that of the previously characterized human and mouse IL-5 genes. Recombinant canine IL-5 protein, expressed in Pichia pastoris, is biologically active in a cell proliferation assay. Canine IL-5 gene sequences and the biologically active protein described in this study will be useful reagents for future studies of this cytokine in physiologic processes and in pathologic conditions of the dog.
Momentum Transfer for an Aerodynamic Plasma Actuator with an Imposed Boundary Layer (2006)

In previous work at the United States Air Force Academy, the phenomenology and behavior of the aerodynamic plasma actuator (a dielectric barrier discharge (DBD)) has been investigated. In order to provide additional insight into the phenomenology associated with the transfer of momentum to air by a plasma flow actuator, the velocity distributions upstream and downstream of a plasma actuator with an induced boundary layer were measured using freestream velocities of approximately 4.6 and 6.8 m/s for a range of frequencies (5-20 kHz) and voltages (7.5-10 kV amplitude). The body forces on the air were calculated using a control volume momentum balance. The results show that the body force acts in the sub-boundary layer region. For constant voltage, the body force is proportional to frequency producing a constant impulse per cycle, and the energy dissipation per cycle and efficiency are independent of frequency. The body forces are not affected by the freestream velocity.
Efficient techniques for canceling transceiver noise (2013)

High-speed data transceiver circuits employ several techniques for dealing with noise, such as using differential architectures. However, under certain circumstances, a transceiver's dominant noise can be bounded and band-limited; and in those cases simpler noise cancellation circuits may suffice. For such transceivers we have designed a tracking circuit to effectively suppress noise. In a 40 nm CMOS technology the tracking circuit consumes a 37% power overhead over a baseline receiver.
Video-ReTime: Learning Temporally Varying Speediness for Time Remapping (2022)

We propose a method for generating a temporally remapped video that matches the desired target duration while maximally preserving natural video dynamics. Our approach trains a neural network through self-supervision to recognize and accurately localize temporally varying changes in the video playback speed. To re-time videos, we 1. use the model to infer the slowness of individual video frames, and 2. optimize the temporal frame sub-sampling to be consistent with the model's slowness predictions. We demonstrate that this model can detect playback speed variations more accurately while also being orders of magnitude more efficient than prior approaches. Furthermore, we propose an optimization for video re-timing that enables precise control over the target duration and performs more robustly on longer videos than prior methods. We evaluate the model quantitatively on artificially speed-up videos, through transfer to action recognition, and qualitatively through user studies.
Microstructure and Microtexture in Nb-Silicide Based Composites (1998)

Abstract Directionally solidified in-situ composites based on niobium and niobium silicides, such as Nb5Si3 and Nb3Si, are presently under investigation as structural materials [1, 2], Alloying additions of elements such as Hf, Ti and Mo to these silicides are also being explored in order to increase strength and oxidation resistance. The present paper describes the effect of Hf, Mo and Ti additions on microstructure and microtexture of high temperature silcide-based in-situ composites. Alloys were prepared from high purity elements (&gt;99.9%) using induction levitation melting in a segmented water-cooled copper crucible. The alloys were directionally solidified using the Czochralski method [2], Phase identification was performed using scanning electron microscopy, electron microprobe analysis (EMPA), and automated electron back scattering pattern (EBSP) analysis. Using EBSP, positive phase identification was accomplished by direct comparison of the location and character of the diffraction bands in the experimental pattern with those calculated from simulated patterns generated using the possible structure types.
<title>Fast algorithm for the rendering of three-dimensional surfaces</title> (1994)

It is often desirable to draw a detailed and realistic representation of surface data on a computer graphics display. One such representation is a 3D shaded surface. Conventional techniques for rendering shaded surfaces are slow, however, and require substantial computational power. Furthermore, many techniques suffer from aliasing effects, which appear as jagged lines and edges. This paper describes an algorithm for the fast rendering of shaded surfaces without aliasing effects. It is much faster than conventional ray tracing and polygon-based rendering techniques and is suitable for interactive use. On an IBM RISC System/6000<SUP>TM</SUP> workstation it renders a 1000 X 1000 surface in about 7 seconds.
A Novel Unconventional Antigen MPD5 Elicits Anti-Tumor Humoral Immune Responses in a Subset of Patients with Polycythemia Vera (2007)

In an effort to define the antigenic mechanism that contributes to beneficial therapeutic outcome in patients with polycythemia vera (PV), we screened a human testis cDNA library with serological cloning derived from sera of three PV patients who had undergone therapeutic-induced remission. As a result, we identified a novel antigen, MPD5, which belongs to the group of cryptic antigens with unconventional genomic intron/exon structure. Moreover, MPD5 elicited IgG antibody responses in a subset of PV patients who had benefited from a variety of therapies--including IFN-alpha, Hydroxyurea, Imatinib mesylate, Anagrelide, and phlebotomy--but not in untreated PV patients or healthy donors, suggesting that MPD5 is a PV-associated, therapy-related antigen. In the granulocytes of PV patients who are responsive to therapy, upregulated MPD5 expression may serve to enhance immune responses. These findings provide new insight into the mechanism underlying regulation of the self-antigen repertoire that elicits anti-tumor immune responses in patients with myeloproliferative diseases, indicating the potential of these self-antigens as targets of novel immunotherapy.
Optimal and feedback control for light-based circadian entrainment (2013)

With the emergence of solid state lighting, light-based circadian rhythm control is becoming increasingly feasible. In this paper, we use a popular empirical model proposed by Richard Kronauer to study the entrainment with the light intensity as the control input. Given a reference circadian oscillation, we formulate the entrainment problem as a tracking problem: adjusting the light intensity to drive the circadian rhythm to the reference trajectory. We compare four cases: periodic light entrainment, active open loop optimal entrainment (using both the Kronauer model and a first-order approximation of only the phase response), active feedback entrainment, and subtractive feedback entrainment. Results from this study provide new insight and guideline to light intensity control for circadian rhythm regulation.