gebhart/patrepeval huggingface dataset:
Distributing mapping objects with the Geospatial Information Database (1999)

The Geospatial Information Database (GIDB) is an implementation of ongoing research in object-oriented geographic data modeling at the Naval Research Laboratory's Mapping, Charting and Geodesy Branch. GIDB has evolved from an initial memory-resident application, involving vector mapping data, to the current state-of-the-art system of a distributed object-oriented database with Web-based viewing capabilities for vector, raster, hypertext and multimedia data, as well as remote updating of vector data. The use of geographic data is becoming pervasive across many disciplines. At the same time, end users are becoming increasingly dependent upon the Web as a source of readily available, easily accessible information. We believe these two factors necessitate the development of systems that are capable of immediate distribution and access to complex spatial data objects. In this paper, we present the design strategies and implementation architecture of GIDB.
Chiral Diphosphites and Diphosphoramidites as Cheap and Efficient Ligands in Rh‐Catalyzed Asymmetric Olefin Hydrogenation. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Speculative tag access for reduced energy dissipation in set-associative L1 data caches (2013)

Due to performance reasons, all ways in set-associative level-one (L1) data caches are accessed in parallel for load operations even though the requested data can only reside in one of the ways. Thus, a significant amount of energy is wasted when loads are performed. We propose a speculation technique that performs the tag comparison in parallel with the address calculation, leading to the access of only one way during the following cycle on successful speculations. The technique incurs no execution time penalty, has an insignificant area overhead, and does not require any customized SRAM implementation. Assuming a 16kB 4-way set-associative L1 data cache implemented in a 65-nm process technology, our evaluation based on 20 different MiBench benchmarks shows that the proposed technique on average leads to a 24% data cache energy reduction.
Evaluation of DNA Vaccine Candidates against Foot-and-Mouth Disease Virus in Cattle (2023)

We evaluated four DNA vaccine candidates for their ability to produce virus-like particles (VLPs) and elicit a protective immune response against Foot-and-mouth disease virus (FMDV) in cattle. Two traditional DNA plasmids and two DNA minicircle constructs were evaluated. Both the pTarget O1P1-3C plasmid and O1P1-3C minicircle encoded a wild-type FMDV 3C protease to process the P1-2A polypeptide, whereas the O1P1-HIV-3C<sup>T</sup> minicircle used an HIV-1 ribosomal frameshift to down-regulate expression of a mutant 3C protease. A modified pTarget plasmid with a reduced backbone size, mpTarget O1P1-3C<sup>LT</sup>, used a 3C protease containing two mutations reported to enhance expression. All constructs produced mature FMDV P1 cleavage products in transfected cells, as seen by western blot analysis. Three constructs, O1P1-3C minicircles, pTarget O1P1-3C, and mpTarget O1P1-3C<sup>LT</sup> plasmids, produced intracellular VLP crystalline arrays detected by electron microscopy. Despite VLP formation in vitro, none of the DNA vaccine candidates elicited protection from clinical disease when administered independently. Administration of pTarget O1P1-3C plasmid enhanced neutralizing antibody titers when used as a priming dose prior to administration of a conditionally licensed adenovirus-vectored FMD vaccine. Further work is needed to develop these DNA plasmid-based constructs into standalone FMD vaccines in cattle.
Methods for Quantitative Assessment of Dynamic Knee Joint Stability (2014)

The ability to quantitatively assess dynamic knee joint stability is a major need among biomechanics researchers, orthopaedic surgeons, and physical therapists. For example, following a tear of the anterior cruciate ligament (ACL), surgeons will often perform a manual examination called the pivot-shift test to evaluate the mechanical stability of the knee. Unfortunately the test qualitative, subjective, and difficult to reproduce. Biomechanics researchers have been developing ways to reproduce the pivot-shift in a laboratory setting. However, current approaches involve the application of mechanical loads that are either static or poorly defined. In addition to manual examinations, observational movement analysis is often used by physical therapists to assess the functional stability of the knee during tasks such as a single leg squat. However, the qualitative and subjective nature of observation makes it difficult to reliably document and monitor patient progress. Researchers can use multi-camera motion capture systems to extract quantitative information from functional tests in a laboratory setting. However, these systems are prohibitively expensive and cumbersome for routine use in the clinic. In this dissertation we present novel techniques for quantitatively assessing dynamic knee joint stability in laboratory and clinical settings. First, we provide the mathematical foundation for describing knee joint motion (kinematics) and forces and moments (kinetics). This work extends the concept of a non-orthogonal joint coordinate system to include what's known as the dual Euler basis, which as we show, is particularly useful for representing constraint moments acting at the knee. Next, we present a novel mechanical device for mimicking the pivot-shift test in a laboratory setting. Using this device, we then compare the ability of several pediatric ACL reconstruction techniques to restore stability to the knee in a cadaveric model. Finally, we present a novel marker-based motion capture technique that leverages low-cost consumer 3D cameras like the Microsoft Kinect. We show that, using this technique, the position of markers placed on the body can be measured with 1-2 cm accuracy and precision. Hopefully the work presented in this dissertation will benefit biomechanics researchers, surgeons, and physical therapists who face the increasingly important problem of quantifying knee joint function and stability.
Passive millimeter-wave imaging with compressive sensing (2012)

Passive millimeter-wave (PMMW) imagers using a single radiometer, called single pixel imagers, employ raster scanning to produce images. A serious drawback of such a single pixel imaging system is the long acquisition time needed to produce a high-fidelity image, arising from two factors: (a) the time to scan the whole scene pixel by pixel and (b) the integration time for each pixel to achieve adequate signal to noise ratio. Recently, compressive sensing (CS) has been developed for single-pixel optical cameras to significantly reduce the imaging time and at the same time produce high-fidelity images by exploiting the sparsity of the data in some transform domain. While the efficacy of CS has been established for single-pixel optical systems, its application to PMMW imaging is not straightforward due to its (a) longer wavelength by three to four orders of magnitude that suffers high diffraction losses at finite size spatial waveform modulators and (b) weaker radiation intensity, for example, by eight orders of magnitude less than that of infrared. We present the development and implementation of a CS technique for PMMW imagers and shows a factor-of-ten increase in imaging speed.
Purification and characterization of nitric oxide synthase (NOSNoc) from a Nocardia species (1995)

We previously reported on the occurrence, partial purification, and preliminary characterization of the first reported bacterial nitric oxide synthase. The soluble Nocardia enzyme, designated NOSNoc, has now been purified 1,353-fold by a combination of 2',5'-ADP-agarose affinity chromatography and hydroxylapatite chromatography. NOSNoc runs as a band of M(r) 51,900 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The molecular mass was estimated to be 110.6 +/- 0.5 kDa by gel filtration, indicating that the native enzyme exists as a homodimer in solution. An N-terminal 15-amino-acid sequence was determined for NOSNoc, showing it to be different from known mammalian NOSs. NG-Hydroxy-L-arginine was confirmed to be an intermediate in the enzymatic reaction by stoichiometric determinations of oxygen uptake, NADPH oxidation, NO formation as measured by nitrite determinations, citrulline formation, and kinetic studies. NOSNoc was competitively inhibited by NG-methyl- and NG-nitro-L-arginine with either L-arginine or NG-hydroxyl-L-arginine as the substrate. Furthermore, the stability and pH and temperature optima of NOSNoc have been established.
Hybrid Model Predictive Control of Active-Neutral-Point-Clamped Multilevel Converters (2019)

To reduce the power losses, the high-voltage switches in active-neutral-point-clamped (ANPC) multilevel converters always operates at the fundamental frequency. Moreover, DC-link capacitor and flying capacitor voltage balance control is mandatory in addition to output current control in the ANPC converters. Model predictive control (MPC) can provide this flexibility and feature high dynamics for transient operations. However, conventional MPC experiences variable switching frequency, high total harmonic distortion. Moreover, as there is no modulator in the conventional MPC, it is very hard to guarantee the fundamental-frequency operation of the high-voltage switches. Given the issues above, a hybrid MPC is proposed to control the ANPC converter in this paper, where finite-control-set MPC is utilized for high-voltage switch control, and duty-cycle-optimized MPC is utilized for the low-voltage switch control. The proposed MPC features a fixed switching frequency and improves the steady-state performance with simplified implementation. The validation of the proposed hybrid MPC strategy is conducted on a five-level ANPC converter.
Monoclonal antibody PD41 recognizes an antigen restricted to prostate adenocarcinomas. (1991)

A monoclonal antibody (MAb) designated PD41 (IgG1k) was generated by hyperimmunizing BALB/c mice with a membrane preparation prepared from a moderately to poorly differentiated prostate carcinoma surgical specimen. The immunohistochemical reactivity of MAb PD41 was shown to be highly restricted to the ductal epithelia and secretions of prostate adenocarcinoma tissues. Sixty-five % of the prostate tumor specimens were stained with MAb PD41, whereas no staining of the fetal or benign prostate specimens was observed. PD41 reacted minimally with normal prostate tissues, with less than 1% of the epithelial cells staining. This MAb did not react with nonprostate carcinomas or to a variety of normal human tissues. Using both radioimmunoassay and immunofluorescent procedures, several cultured human tumor cell lines, human blood cells, and purified antigens to prostate-specific antigen and prostatic acid phosphatase also were found not to express the PD41 antigen. MAb PD41 also was shown to bind to the target antigen present in seminal plasma obtained from prostate carcinoma patients but not to seminal plasma from normal donors. Immunoblots of gel-separated components of prostate carcinoma tissue extracts indicate that the molecular weight of the proteins carrying the PD41 antigenic determinant can differ among individual tumors, ranging from Mr 90,000 to greater than 400,000. However, in seminal plasma from prostate cancer patients, the predominant component recognized by PD41 is the diffuse Mr greater than 400,000 band. It appears that this monoclonal antibody may recognize a prostate carcinoma-associated mucin-like antigen, which is preferentially expressed on prostate carcinomas, and therefore, may be a useful marker to distinguish benign prostate hyperplasia from prostate carcinoma.
Identification of<i>Dekkera bruxellensis</i>(<i>Brettanomyces</i>) from Wine by Fluorescence In Situ Hybridization Using Peptide Nucleic Acid Probes (2001)

ABSTRACT A new fluorescence in situ hybridization method using peptide nucleic acid (PNA) probes for identification of Brettanomyces is described. The test is based on fluorescein-labeled PNA probes targeting a species-specific sequence of the rRNA of Dekkera bruxellensis . The PNA probes were applied to smears of colonies, and results were interpreted by fluorescence microscopy. The results obtained from testing 127 different yeast strains, including 78 Brettanomyces isolates from wine, show that the spoilage organism Brettanomyces belongs to the species D. bruxellensis and that the new method is able to identify Brettanomyces ( D. bruxellensis ) with 100% sensitivity and 100% specificity.
Extracting dispersion curves of acoustic data with continuous wavelet transform (2008)

Group and phase velocity (i.e. dispersion) of acoustic data carry important information about the acoustic state of the rock and are important tools for interpretation and for quantitative inversion. In this paper we propose an approach to automatically extract the velocity dispersion (group and phase) of acoustic waves received by an array of receivers without the use of any physical model, user inputs or supervision. The first step consists in applying the continuous wavelet transform to the waveforms recorded by each receiver. Then, the peak on the modulus map is used to determine the time locus of the energy of each mode as a function of frequency. At each frequency, a method of data association is used to find the corresponding loci for all receivers. A straight line is fit to these loci and its slope is used as an estimate for the group velocity at that frequency. Moreover the rate of change of the phase of the complex wavelet coefficients at the locations corresponding to this best-fit straight line can be used to compute an estimate of the phase slowness at the same frequency. Repeating this for all frequencies and all separated modes of interest yields the desired dispersion curves for these modes.
Synthesis of 6-methylthiopenicillins and 7-heteroatom-substituted cephalosporins (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 6-methylthiopenicillins and 7-heteroatom-substituted cephalosporinsWilliam A. Slusarchyk, Harold E. Applegate, Phillip Funke, William Koster, Mohinder S. Paur, Marian Young, and Joseph E. DolfiniCite this: J. Org. Chem. 1973, 38, 5, 943–950Publication Date (Print):March 1, 1973Publication History Published online1 May 2002Published inissue 1 March 1973https://pubs.acs.org/doi/10.1021/jo00945a023https://doi.org/10.1021/jo00945a023research-articleACS PublicationsRequest reuse permissionsArticle Views198Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fast, Convenient, and Efficient Molybdenum-Catalyzed Asymmetric Allylic Alkylation under Noninert Conditions: An Example of Microwave-Promoted Fast Chemistry (2000)

Microwave heating allows regio- and enantioselective allylic alkylation to be carried out in air in a few minutes in a convenient one-pot procedure [Eq. (1)]. The catalytically active molybdenum(0) species was formed in situ from inexpensive [Mo(CO)6] and a chiral ligand.
The fault recording and reporting method (2002)

The patent-pending Fault Recording and Reporting Method uses a large amount of diverse information output from various line-replaceable units (LRUs) and other components of the aircraft during a mission through bulk storage on electronic media. After the aircraft lands, the electronic media are removed, accessed by an appropriate apparatus, and presented in a format that can be read with a personal computer (PC). This information provides the user, typically a service technician, with information relating to the aircraft's flight; specifically, various fault indications provided by LRUs and other components. From this information, the service technician can determine whether or not a fault indication recorded during the flight is a legitimate fault requiring removal of the affected LRU or component for further diagnostic testing. The method significantly reduces incidents of no-fault-found (NFF) diagnostic test results and saves labor hours that would otherwise be spent testing properly operating LRUs and components. The method minimizes on-aircraft data interpretations, rendering unnecessary on-board maintenance processors and technicians for LRU troubleshooting.
Speckle-Free Imaging with Nanosecond-Scale Acquisition Using Microlens-Stabilized Laser Arrays (2018)

A novel light source comprising as many as 4,000 independent lasers has been developed for speckle-free illumination. Visible-light and near-infrared imaging with exposure time as short as five nanoseconds has been demonstrated.
Yeast Recombinase FLP Functions Effectively in Human Cells for Construction of Adenovirus Vectors (2000)

We have recently developed a high-efficiency method of constructing adenovirus vectors based on Cre-mediated recombination between two plasmids co-transfected into 293 cells. The simplicity and efficiency of this method should greatly expedite the construction of most recombinant vectors. However, this system would not be suitable for constructing vectors bearing loxP sites elsewhere in the genome because of undesirable Cre-mediated vector rearrangements. To address this, we have developed a similar system using FLP-mediated site-specific recombination for the construction of adenovirus vectors.
Automated Pupil Perimetry (1990)

Objective tests of visual function are reliable indicators of disease and are not influenced by a patient's fears and biases. Unfortunately, there are few such tests available. We were interested in testing the feasibility of using automated pupil perimetry as an objective means of assessing the visual field. Although previous attempts at pupil perimetry did suggest it could be used to assess afferent visual function, the lack of a sensitive means to quantitate the pupil response, automatically analyze it, and produce a reproducible, automated, stimulus source has kept it from becoming a useful clinical and research tool. In order to overcome these problems we developed 1) the instrumentation to accurately quantitate changes in pupil area, 2) a software program to collect the data and analyze it with respect to various response parameters (ie change in pupil area and latency time), and 3) a link between an automated perimeter (the Humphrey Field Analyzer) and a computer-based pupillometer. By using the Humphrey Field Analyzer, we were able to compare focal pupil responses to static visual threshold testing in the same subject.
Finding iconic images (2009)

We demonstrate that is it possible to automatically find representative example images of a specified object category. These canonical examples are perhaps the kind of images that one would show a child to teach them what, for example a horse is - images with a large object clearly separated from the background. Given a large collection of images returned by a web search for an object category, our approach proceeds without any user supplied training data for the category. First images are ranked according to a category independent composition model that predicts whether they contain a large clearly depicted object, and outputs an estimated location of that object. Then local features calculated on the proposed object regions are used to eliminate images not distinctive to the category and to cluster images by similarity of object appearance. We present results and a user evaluation on a variety of object categories, demonstrating the effectiveness of the approach.
Sorting Single-Walled Carbon Nanotubes by Electronic Type Using Nonionic, Biocompatible Block Copolymers (2010)

As-synthesized single-walled carbon nanotubes (SWNTs) typically possess a range of diameters and electronic properties. This polydispersity has hindered the development of many SWNT-based technologies and encouraged the development of postsynthetic methods for sorting SWNTs by their physical and electronic structure. Herein, we demonstrate that nonionic, biocompatible block copolymers can be used to isolate semiconducting and metallic SWNTs using density gradient ultracentrifugation. Separations conducted with different Pluronic block copolymers reveal that Pluronics with shorter hydrophobic chain lengths lead to higher purity semiconducting SWNTs, resulting in semiconducting purity levels in excess of 99% obtained for Pluronic F68. In contrast, X-shaped Tetronic block copolymers display an affinity for metallic SWNTs, yielding metallic purity levels of 74% for Tetronic 1107. These results suggest that high fidelity and high yield density gradient separations can be achieved using nonionic block copolymers with rationally designed homopolymer segments, thus generating biocompatible monodisperse SWNTs for a range of applications.
A printed MIMO antenna system with CLLs for isolation enhancement (2013)

A metamaterial based isolation enhancement technique is proposed. A 4-shaped MIMO antenna system is used to demonstrate the effect of the a metamaterial based isolation structure between the radiating elements. The isolation structure is capable of enhancing the isolation for the dual band MIMO antenna system under consideration. Printed CLLs on the top layer of the antenna system provides the isolation for high band (2.3-2.98Ghz). The ground layer complementary CLLs are used to enhance the isolation in the low band (827-853MHz). The minimum isolation for the low band and high band was 18.9dB and 9.8dB respectively.
Characterization of monoclonal antibodies to human melanoma-associated antigens (1981)

The hybridomas No. 165.28T, No. 473.54S, and No. 653.25N derived from the fusion of myeloma cells with splenocytes from mice immunized with cultured human melanoma cells secreted monoclonal antibodies recognizing antigenic determinants maximally expressed on cultured human melanoma cells and freshly explanted melanoma cells. Monoclonal antibody No. 376.74T reacted also with carcinoma cell lines but with a significantly lower titer. Rosette inhibition assay showed that these antigenic determinants were expressed on antigenic structures, which are not associated with beta 2 microglobulin and histocompatibility antigens. Two monoclonal antibodies recognized the same or closely associated antigenic determinants, and the remaining two monoclonal antibodies reacted with distinct antigenic determinants. All four monoclonal antibodies could mediate antibody-dependent cellular cytotoxicity of cultured melanoma cells, but none could mediate complement-dependent cytotoxicity.