gebhart/patrepeval huggingface dataset:
CCL3 (MIP-1α) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2 (2004)

CCL3 (MIP-1alpha), a prototype of CC chemokines, is a potent chemoattractant toward human neutrophils pre-treated with GM-CSF for 15 min. GM-CSF-treated neutrophils migrate also to the selective CCR5 agonist CCL4 (MIP-1beta). CCL3- and CCL4-triggered migration of GM-CSF-primed neutrophils was inhibited by the CCR5 antagonist TAK-779. Accordingly, freshly isolated neutrophils express CCR5. Extracellular signal-regulated kinases (ERK)-1/2 and p38 mitogen-activated protein kinase (MAPK) inhibitors blocked CCL3-induced migration of GM-CSF-primed neutrophils. When the activation of ERK-1/2 and p38 MAPK by CCL3 and the classical neutrophilic chemokine CXCL8 (IL-8) were compared, both the chemokines were capable of activating p38 MAPK. On the contrary, whereas both ERK-1 and ERK-2 were activated by CXCL8, no ERK-1 band was detectable after CCL3 triggering. Finally, neutrophil pre-treatment with GM-CSF activated both ERK-1 and ERK-2. This suggests that by activating ERK-1, GM-CSF renders neutrophils rapidly responsive to CCL3 stimulation throughout CCR5 which is constitutively expressed on the cell surface.
Energy efficient network data transport through adaptive compression using the DEEP platforms (2012)

Direct measurement of event and component resolved energy dissipation in computing systems is critical for energy optimization of computing and networking applications. Prior research focuses on development of energy consumption models and custom-built energy measurement systems, but suffers from critical drawbacks. This paper addresses these limitations and presents solutions using DEEP (Decision-support for Energy Efficient Processing). DEEP is a rapidly-deployed open-source energy measurement platform architecture. The platform provides an unprecedented ability to non-intrusively measure the energy consumption associated with execution of software application code. DEEP is implemented as both an online and offline version. Evaluation demonstrates processing and energy overheads less than 1% for offline and about 5% for the online implementation. The DEEP implementation investigates the impact of data compression on network data transport. An intelligent data compression and transport algorithm is developed using the decision-support capabilities of DEEP. The algorithm creates significant energy savings (38%) in network data transport using dynamic selection of compression schemes to adapt to varying system and wireless network conditions.
Low-temperature processed Schottky-gated field-effect transistors based on amorphous gallium-indium-zinc-oxide thin films (2010)

We have investigated the electrical properties of metal-semiconductor field-effect transistors (MESFET) based on amorphous oxide semiconductor channels. All functional parts of the devices were sputter-deposited at room temperature. The influence on the electrical properties of a 150 °C annealing step of the gallium-indium-zinc-oxide channel is investigated. The MESFET technology offers a simple route for processing of the transistors with excellent electrical properties such as low subthreshold swing of 112 mV/decade, gate sweep voltages of 2.5 V, and channel mobilities up to 15 cm2/V s.
Powerline communication over special systems (2005)

Powerline communication (PLC) has undergone a rapid development in recent years both for Internet access and home networking. Besides these well-known residential applications, PLC is also applicable for special systems, such as airfield lighting control and ship power distribution network. Using PLC as transmission medium to realize switching and monitoring of airfield halogen lamps and other information exchange is an efficient and safe way to accelerate telematics in aviation. Applying PLC in ship environment can support provision of traditional and novel value-added services both for operators and customers. In this paper we present a laboratory trial to investigate applicability of PLC over an airfield lighting system and an in-vivo test to evaluate the applicability of PLC linked by ship's power distribution system. Our research suggests that PLC is a strong candidate for data communications also in these special environments.
DEHP‐plasticised PVC: relevance to blood services<sup>*</sup> (2010)

Phthalates are the most widely used plasticisers in the world and have been in medical use since 1955. Di(2-ethylhexyl)phthalate (DEHP) is present in many industrial and domestic products, and is a common plasticiser used in blood bags and tubing sets. Concerns have been raised by environmental groups that DEHP exposure may result in gender birth defects and the feminisation of boys although there were no studies performed of intravenous exposure to DEHP on higher mammals or humans which report similar effects. This article reports on the toxicology of DEHP and considers concerns regarding its use in the context of transfusion medicine. The benefits of using DEHP are evaluated and the use of alternative plasticisers to DEHP is explored. The article reports on international and European regulatory recommendations for DEHP use in transfusion medicine and examines the impact of legislation on the medical devices and blood industries. The article also reviews labelling considerations for blood components and offers some guidance for blood establishments in respect of DEHP use.
A Unified Approach to Variable Voltage Scheduling for Nonideal DVS Processors (2004)

Voltage scheduling is an essential technique used to exploit the benefit of dynamic voltage-scaling processors. Though extensive research exists in this area, current processor limitations such as time and energy transition overhead and voltage-level discretization are often dismissed as insignificant. We show that for hard real-time applications, disregarding these details can lead to suboptimal or even invalid results. We propose two algorithms to account for these limitations. The first is a greedy approach, while the second is more complex, but can significantly reduce the system's energy consumption. Through experimental results on both real and randomly generated systems, we show the effectiveness of both algorithms and explore what conditions make it beneficial to use the complex algorithm over the basic one.
PRADO (2017)

To survive and stand out from the fierce market competition nowadays, it is critical for app developers to know (desirably ahead of time) whether, how well, and why their apps would be adopted by users. Ideally, the adoption of an app could be predicted by factors that can be controlled by app developers in the development process, and factors that app developers are able to take actions on and improve according to the predictions. To this end, this paper proposes PRADO, an approach to measuring various aspects of user adoption, including app download and installation, uninstallation, and user ratings. PRADO employs advanced machine learning algorithms to predict user adoption based on how these metrics correlate to a comprehensive taxonomy of 108 developer-controllable features of the app. To evaluate PRADO, we use 9,824 free apps along with their behavioral data from 12.57 million Android users, demonstrating that user adoption of a new app can be accurately predicted. We also derive insights on which factors are statistically significant to user adoption, and suggest what kinds of actions can be possibly performed by developers in practice.
Realtime Software Defined Self-Interference Cancellation Based on Machine Learning for In-Band Full Duplex Wireless Communications (2018)

The key enabling technology to in-band full duplex wireless is the self-interference cancellation. This paper proposes a realtime software defined digital self-interference cancellation based on machine learning. The contributions of this work include: (1) a digital self-cancellation scheme that approaches to the limit of the hardware, and (2) an open software defined cancellation framework that supports the realtime cancellation using machine learning algorithms with synchronized iterative training and prediction. This solution is implemented and evaluated on a software defined radio testbed. It results in performance of 50 dB in digital cancellation, which is close to the hardware limit and significantly outperformed available literature digital cancellation solutions. It also demonstrates stable performance across spectral band.
The use of alpha-methyl-D-glucoside, a synthetic analogue of maltose, as inducer of amylase by Aspergillus sp in solid-state and submerged fermentations (2001)

The use of a methyl-D-glucoside (alphaMG), a synthetic analogue of maltose, as carbon source and inducer of amylase synthesis to several species of Aspergillus was studied in submerged and solid-state fermentations. Among a group of ten species, A. tamarii, A. fumigatus and A. flavus were able to produce biomass and high specific amylolytic activity in submerged cultures containing alphaMG as the only carbon source. In solid state fermentation, the enrichment of basal wheat bran or corn cob medium with alphaMG increased up to 3 times the production of amylases. In both submerged and solid state fermentations, alphaMG was more effective inducer of amylases than maltose and starch.
Macrophage Fc receptor activity modulates mesangial cell proliferation and matrix synthesis (1994)

Substantial in vivo evidence exists to implicate the macrophage (M phi) in modulating mesangial expansion and glomerulosclerosis (GS) following renal injury. We studied in an in vitro system how M phi activation via Fc-receptor-mediated endocytosis, such as occurs in immune complex-mediated disease states, may influence the effect of M phi secretory products (MSP) on mesangial cell (MC) proliferation and matrix synthesis. MSP from M phi incubated with immunoglobulin G (IgG) complexes caused significantly greater (P < 0.001) enhancement of MC [3H]thymidine incorporation compared with MSP from unstimulated M phi or from M phi activated via nonspecific endocytosis (P < 0.001). MSP from M phi incubated with IgG complexes plus the inhibitor of endocytosis cytochalasin B showed an attenuated effect on MC proliferation (P < 0.02). MSP were also found to enhance MC matrix synthesis (P < 0.001). These data demonstrate that MSP can play a direct role in mesangial expansion by increasing both MC proliferation and matrix synthesis. Surface binding alone of IgG complexes may not be sufficient to activate M phi and enhance their mitogenic effect on MC as endocytosis appears to be required. These findings lend in vitro support to a potential role for the M phi in the process of mesangial expansion and GS following renal injury.
Cylindrical-lens-based wavefront-reversing shear interferometer for the spatial coherence measurement of UV radiations (2006)

We present the design and results of a cylindrical-lens-based reversal shear interferometer for measuring the spatial coherence of partially or fully coherent UV beams. This is a modified Michelson interferometer consisting of only four optical components. The wavefront is reversed in one of the interferometer's arm by the combination of a plane mirror located at the focal plane of a cylindrical lens. The selected wavefront can be sheared at any arbitrary angle with respect to the incident wavefront by rotating the cylindrical lens, thus enhancing the capability of this design for a real 3-D wavefront evaluation. This interferometer is used to measure the spatial coherence of 255-nm UV radiations obtained from the second harmonic of a copper vapor laser for pump beams of different spatial coherence characteristics, a result being reported for the first time.
Long-Chain Acyl-Homoserine Lactone Quorum-Sensing Regulation of <i>Rhodobacter capsulatus</i> Gene Transfer Agent Production (2002)

Many proteobacteria use acyl-homoserine lactones as quorum-sensing signals. Traditionally, biological detection systems have been used to identify bacteria that produce acyl-homoserine lactones, although the specificities of these detection systems can limit discovery. We used a sensitive approach that did not require a bioassay to detect production of long-acyl-chain homoserine lactone production by Rhodobacter capsulatus and Paracoccus denitrificans. These long-chain acyl-homoserine lactones are not readily detected by standard bioassays. The most abundant acyl-homoserine lactone was N-hexadecanoyl-homoserine lactone. The long-chain acyl-homoserine lactones were concentrated in cells but were also found in the culture fluid. An R. capsulatus gene responsible for long-chain acyl-homoserine lactone synthesis was identified. A mutation in this gene, which we named gtaI, resulted in decreased production of the R. capsulatus gene transfer agent, and gene transfer agent production was restored by exogenous addition of N-hexadecanoyl-homoserine lactone. Thus, long-chain acyl-homoserine lactones serve as quorum-sensing signals to enhance genetic exchange in R. capsulatus.
Micro- and Nano-Carrier Mediated Intra-Articular Drug Delivery Systems for the Treatment of Osteoarthritis (2011)

The objective of this paper is to provide readers with current developments of intra-articular drug delivery systems. In recent years, although the search for a clinically successful ideal carrier is ongoing, sustained-release systems, such as polymeric micro- and nanoparticles, liposomes, and hydrogels, are being extensively studied for intra-articular drug delivery purposes. The advantages associated with long-acting preparations include a longer effect of the drug in the action site and a reduced risk of infection due to numerous injections consequently. This paper discusses the recent developments in the field of intra-articular sustained-release delivery systems for the treatment of osteoarthritis.
Nonenzymatic glucose sensor based on disposable pencil graphite electrode modified by copper nanoparticles (2016)

A nonenzymatic glucose sensor based on a disposable pencil graphite electrode (PGE) modified by copper nanoparticles [Cu(NP)] was prepared for the first time. The prepared Cu(NP) exhibited an absorption peak centered at ∼562 nm using UV-visible spectrophotometry and an almost homogenous spherical shape by scanning electron microscopy. Cyclic voltammetry of Cu(NP)-PGE showed an adsorption controlled charge transfer process up to 90.0 mVs<sup>-1</sup>. The sensor was applied for the determination of glucose using an amperometry technique with a detection limit of [0.44 (±0.01) μM] and concentration sensitivity of [1467.5 (±1.3) μA/mMcm<sup>-2</sup>]. The preparation of the Cu(NP)-PGE sensor was reproducible (relative standard deviation = 2.10%, n = 10), very simple, fast, and inexpensive, and the Cu(NP)-PGE is suitable to be used as a disposable glucose sensor.
Paleomagnetism and Age of Nonacho Group Sandstones and Associated Sparrow Dikes, District of Mackenzie (1974)

The Nonacho Group is a folded sequence of sedimentary rocks resting on a crystalline basement of probable Archean age. Both sedimentary and basement rocks are intruded by the Sparrow dikes. Fifty-four samples from 10 dikes have a stable magnetization with mean direction after a.f. cleaning of 131°, +51 °(N = 10, k = 50, α 95 = 7°) and a corresponding pole at 12 °N, 069 °W. The presence of reversals and the approximate agreement between dikes and their baked contracts are taken to indicate that the dikes were probably magnetized at the time of intrusion. 40 Ar– 39 Ar studies suggest that the probable age of intrusion was about 1700 m.y. The magnetization of the Nonacho sedimentary rocks collected at 12 sites (40 samples) have a mean direction after thermal cleaning of 148°, + 57 °(N = 12, k = 11, α 95 = 14°) without correction for geological dip. The corresponding pole is at 13 °N, 086 °W. The precision after correction for geological dip is low (k = 3), so the magnetization is predominantly post-folding. The thermal decay characteristics and the geometry of the directions indicate that the magnetization of the sedimentary rocks was acquired during cooling following a period of mild heating presumably owing to deep burial. This process of secondary magnetization apparently reached its culmination between about 1700 and 1600 m.y., and continued with diminishing intensity until about 1400 m.y. These results are used to modify the apparent polar wandering path for the Canadian Shield, so that the path now has a sharp bend (Hairpin 40) at about 1800 m.y. rather than at 1950 m.y. as previously postulated.
A Butanol Olfactometer for Field Measurement of Ambient Odors (1984)

A portable 1-butanol olfactometer was developed for quantifying odors in ambient air.Panelists compare the intensity of ambient odors with the intensity of discrete levels of 1-butanol provided by the olfactometer.Range of delivered 1-butanol concentrations Is 0 to 80 ppm in air at a flow rate of 15 L/min.Laboratory tests were performed to ascertain overall precision, consistency of panelist responses, uniqueness of each odor step, variability between two Identical olfactometers, and effect of delivery method.For 855 pairs of matched odor Intensities, the ratio of measured butanol concentration to set concentration averaged 0.984 or -0.023 scale steps (where the scale steps differ In concentration by factors of two).In field experiments the equivalent ambient odor Intensities determined by odor panels using the butanol olfactometer ranged from 1.5 ppm to 64 ppm of 1-butanol vapor In air.The precision of ambient odor measurements was within one-half scale step on the 1-butanol olfactometer, sufficient for most odor investigation and abatement research applications.
NAD(P)H and FAD as Biomarkers for Programmed Cell Death (2014)

Mitochondria play an important role in the process of cell death, which is now recognized as a complex continuum of mechanisms that include program cell death (apoptosis), necrosis, and autophagy (Kim et al. 2006). Apoptosis is a highly regulated and energy-dependent multistep biological process (Hetts 1998). Dysregulation of apoptosis-either abnormal initiation of the genetic self-termination program or failure to undergo apoptosis-causes various diseases, such as autoimmunity, neurodegeneration, heart disease, and cancer. Apoptosis generally operates via two pathways: (1) mitochondria-and (2) receptor-mediated. In the mitochondria-mediated pathway, an external insult acts on mitochondria with or without the action of proapoptotic proteins, to cause cytochrome c release from the mitochondria to the cytoplasm, which is accompanied by the loss of the mitochondrial membrane potential. Released cytochrome c interacts with apoptotic protease-activating factor 1 (Apaf-1), ATP, and procaspase 9 to form an apoptosome. Apoptosome then activates a cascade of cellular destruction events, beginning with the activation of death-execution eector caspases, such as caspase 3, and then the activation of downstream caspases, ultimately resulting in the hallmark of apoptosis, including condensation of nuclear and cytoplasmic contents, fragmentation of nuclear DNA, and membrane blebbing (Blankenberg 2008; Schon and Manfredi 2003).
Population-based analysis of arteriovenous malformation treatment (2001)

In centers with population-based referral, AVM of the brain is predominantly a disease related to intracranial bleeding. and parenchymal clots have a profound impact on overall management outcome. The rupture of an AVM is as devastating as that of an aneurysm. Aneurysm ruptures are more lethal, whereas AVM rupture tends to result in more neurological disability due to the high occurrence of lobar intracerebral hematoma. In an attempt to quantify the need for different modalities of AVM treatment based on a population of 1,000,000 people, figures for surgeries performed range from six to 10 operations per year and embolization as well as gamma knife surgery procedures range from two to seven per year, depending on the strategy at hand. When using nonsurgical approaches to Grade 1 to 3 lesions, the number of patients requiring treatment with more than one method for obliteration increases drastically as does the potential risk for procedure-related complications.
Osteopontin as a target for cancer therapy (2008)

Osteopontin (OPN) is a glycophosphoprotein cytokine that has multiple functions. OPN is expressed and secreted by various cells, and has a role in cell adhesion, chemotaxis, prevention of apoptosis, invasion, migration and anchorage-independent growth of tumor cells. Extensive research has demonstrated the pivotal participation of OPN in the regulation of cell signaling which controls neoplastic and malignant transformation. The elevated expression of OPN has been observed in a variety of cancers. OPN has been linked with tumor metastasis and signifies a poor prognosis for the patient. This review details the mechanisms by which OPN facilitates these pathological events. It will also show that gaining an understanding of the mechanism of OPN's action at a cellular level has led to the development of a number of therapeutic strategies against the cytokine. These include inhibiting its expression, antagonizing cell surface receptor activation and blocking downstream cell signaling pathways. In addition to the potential of these therapies, serum levels of OPN could be used as a diagnostic and prognostic marker. The authors propose that with further research and development, osteopontin directed treatment could greatly enhance outcomes for cancer patients.
놀이치료 사례 연구 동향 분석 - 국내 석·박사 학위 논문(2011-2019)을 중심으로 - (2019)

The purpose of this study is to identify research trends in theses for master''s and doctorate degrees during the domestic play therapy case study from 2011 to 2019 to form the basis for the design of effective play treatment programs in the future. To this end, 82 papers on domestic play therapy cases, such as master''s and doctorate degrees, were analyzed using the publication year, target, research subject, and play therapy approach. As a suggestion for future research, it is necessary to expand and implement the scope from the initial study of play therapy to the latest study, and second, to expand the research field including academic journals, and third, to address annual age, characteristics, research topics and approaches in general. Fourth, it is necessary to analyze overseas research trends, and fifth, to develop effective play therapy programs for certain types of clients.
Effects of solid surfaces on hydrate kinetics and stability (2009)

Abstract Reservoirs of clathrate hydrates of natural gases (hydrates), found worldwide and containing huge amounts of bound natural gases (mostly methane), represent potentially vast and yet untapped energy resources. Since CO 2 ‐containing hydrates are considerably more stable thermodynamically than methane hydrates, if we find a way to replace the original hydrate-bound hydrocarbons with the CO 2 , two goals can be accomplished at the same time: safe storage of carbon dioxide in hydrate reservoirs, and in situ release of hydrocarbon gas. We have applied the techniques of magnetic resonance imaging as a tool to visualize the conversion of CH 4 hydrate within Bentheim sandstone matrix into the CO 2 hydrate. Corresponding model systems have been simulated using the phase field theory approach. Our theoretical studies indicate that the kinetic behaviour of the systems closely resembles that of CO 2 transport through an aqueous solution. We have interpreted this to mean that the hydrate and the matrix mineral surfaces are separated by liquid-containing channels. These channels will serve as escape routes for released natural gas, as well as distribution channels for injected CO 2 .