gebhart/patrepeval huggingface dataset:
Filling of Deep Trench by Epitaxial SiC Growth (2013)

We performed deep trench filling by using epitaxial SiC growth. It was found that the trench filling condition depend on trench width. A high growth temperature was needed to fill a narrow trench and a low growth temperature was needed to fill a wide trench structure. We optimized the filling condition and successfully filled 7μ m deep and 2 μm wide trench without void formation. We also investigated the 2D doping distribution of the filled area by SSRM. As a result, it is found that the existence of a sub-trench was related to the generation of a doping distribution in the filled area. The trench filling mechanism and doping distribution are discussed.
Detection of <i>Mycoplasma pneumoniae</i> in Spiked Clinical Samples by Nucleic Acid Sequence-Based Amplification (2002)

Isothermal nucleic acid sequence-based amplification (NASBA) was applied to the detection of Mycoplasma pneumoniae. M. pneumoniae RNA prepared from a plasmid construct was used to assess the sensitivity of the assay, and an internal control for the detection of inhibitors was constructed. The sensitivity of the NASBA assay was 10 molecules of wild-type M. pneumoniae RNA generated in vitro and 5 color-changing units (CCU) of M. pneumoniae. An appropriate specimen preparation procedure was developed: after protease treatment of the respiratory specimens, guanidine thiocyanate lysis solution (4.7 M guanidine thiocyanate [Sigma-Aldrich NV], 46 mM Tris-HCl [Merck, Darmstadt, Germany], 20 mM EDTA [Sigma-Aldrich NV], 1.2% [wt/vol] Triton X-100 [Sigma-Aldrich NV], pH 6.2.) was added. With spiked throats, nasopharyngeal aspirates, bronchoalveolar lavage specimens, and sputum specimens, the sensitivity of the NASBA assay in the presence of the internal control was 2 x 10(4) molecules of in vitro-generated RNA or 5 CCU of M. pneumoniae. The sensitivity of the NASBA assay was comparable to that of a PCR targeted to the P1 adhesin gene. Fifteen clinical specimens positive for M. pneumoniae by PCR were also positive by NASBA. These results indicate that the sensitivity of detection of M. pneumoniae in spiked respiratory samples by NASBA is high. Together with the use of the internal control, the assay merits evaluation as a diagnostic tool.
A Rapid and Fluorogenic TMP-AcBOPDIPY Probe for Covalent Labeling of Proteins in Live Cells (2014)

Protein labeling is enormously useful for characterizing protein function in cells and organisms. Chemical tagging methods have emerged as a new generation protein labeling strategy in live cells. Here we have developed a novel and versatile TMP-AcBOPDIPY probe for selective and turn-on labeling of proteins in live cells. A small monomeric tag, E. coli dihydrofolate reductase (eDHFR), was rationally designed to introduce a cysteine in the vicinity of the ligand binding site. Trimethoprim (TMP) that specifically binds to eDHFR was linked to the BOPDIPY fluorophore containing a mildly thiol-reactive acrylamide group. TMP-AcBOPDIPY rapidly labeled engineered eDHFR tags via a reaction termed affinity conjugation (a half-life of ca. 2 min), which is one of the top fast chemical probes for protein labeling. The probe displays 2-fold fluorescence enhancement upon labeling of proteins. We showed that the probe specifically labeled intracellular proteins in live cells without and with washing out the dye. We demonstrated its utility in visualizing intracellular processes by fluorescence-lifetime imaging microscopy (FLIM) measurements.
Image processing for old movies by filters with motion detection (2005)

Old movies suffer from various types of degradation: severe noise, blurred edges of objects (low contrast), scratches, spots, etc. Finding an efficient denoising method is one of the most important and one of the oldest problems in image sequence processing. The crucial thing in image sequences is motion. If the motion is insignificant, then any motion noncompensated method of filtering can be applied. However, if the noise is significant, then this approach gives most often unsatisfactory results. In order to increase the quality of frames, motion compensated filters are usually applied. This is a very time consuming and awkward approach due to serious limitations of optical flow methods. In this paper, a review of various filters with motion detection when applied to the processing of image sequences coming from old movies is presented. These filters are nonlinear and based on the concept of multistage median filtering or mathematical morphology. Some new filters are proposed. The idea of these new filters presented here is to detect moving areas instead of performing full estimation of motion in the sequence and to apply exclusively 2D filters in those regions while applying 3D motion noncompensated filters in static areas, which usually significantly reduces the computational burden.
Proof of Vote: A High-Performance Consensus Protocol Based on Vote Mechanism & Consortium Blockchain (2017)

Bitcoin introduces a revolutionary decentralized consensus mechanism. However, Bitcoin-derived consensus mechanisms applied to public blockchain are inadequate for the deployment scenarios of budding consortium blockchain. We propose a new consensus algorithm, Proof of Vote (POV). The consensus is coordinated by the distributed nodes controlled by consortium partners which will come to a decentralized arbitration by voting. The key idea is to establish different security identity for network participants, so that the submission and verification of the blocks are decided by the agencies' voting in the league without the depending on a third-party intermediary or uncontrollable public awareness. Compared with the fully decentralized consensus-Proof of Work (POW), POV has controllable security, convergence reliability, only one block confirmation to achieve the transaction finality, and low-delay transaction verification time.
Gorlin's Syndromes of the Head and Neck (2010)

This classic text covers over 700 different genetic syndromes involving the head and neck, and has established itself as the definitive, comprehensive work on the subject. The discussion covers the phenotype spectrum, epidemiology, mode of inheritance, pathogenesis, and clinical profile of each condition, all of which is accompanied by a wealth of illustrations. The authors are recognized leaders in the field, and their vast knowledge and strong clinical judgment will help readers make sense of this complex and burgeoning field. As in all fields of genetics, there has been an explosion in the genetics of dysmorphology syndromes, and the authors have completely updated all chapters in light of the discoveries of the Human Genome Project and other ongoing advances. New syndromes have been added and information on existing syndromes has been revised.
TAL effectors mediate high-efficiency transposition of the piggyBac transposon in silkworm Bombyx mori L (2015)

The piggyBac (PB) transposon is one of the most useful transposable elements, and has been successfully used for genetic manipulation in more than a dozen species. However, the efficiency of PB-mediated transposition is still insufficient for many purposes. Here, we present a strategy to enhance transposition efficiency using a fusion of transcription activator-like effector (TALE) and the PB transposase (PBase). The results demonstrate that the TALE-PBase fusion protein which is engineered in this study can produce a significantly improved stable transposition efficiency of up to 63.9%, which is at least 7 times higher than the current transposition efficiency in silkworm. Moreover, the average number of transgene-positive individuals increased up to 5.7-fold, with each positive brood containing an average of 18.1 transgenic silkworms. Finally, we demonstrate that TALE-PBase fusion-mediated PB transposition presents a new insertional preference compared with original insertional preference. This method shows a great potential and value for insertional therapy of many genetic diseases. In conclusion, this new and powerful transposition technology will efficiently promote genetic manipulation studies in both invertebrates and vertebrates.
Generating efficient plans for queries using views (2001)

We study the problem or generating efficient, equivalent rewritings using views to compute the answer to a query. We take the closed-world assumption, in which views are materialized from base relations, rather than views describing sources in terms of abstract predicates, as is common when the open-world assumption is used. In the closed-world model, there can be an infinite number of different rewritings that compute the same answer, yet have quite different performance. Query optimizers take a logical plan (a rewriting of the query) as an input, and generate efficient physical plans to compute the answer. Thus our goal is to generate a small subset of the possible logical plans without missing an optimal physical plan. We first consider a cost model that counts the number of subgoals in a physical plan, and show a search space that is guaranteed to include an optimal rewriting, if the query has a rewriting in terms of the views. We also develop an efficient algorithm for finding rewritings with the minimum number of subgoals. We then consider a cost model that counts the sizes of intermediate relations of a physical plan, without dropping any attributes, and give a search space for finding optimal rewritings. Our final cost model allows attributes to be dropped in intermediate relations. We show that, by careful variable renaming, it is possible to do better than the standard “supplementary relation” approach, by dropping attributes that the latter approach would retain. Experiments show that our algorithm of generating optimal rewritings has good efficiency and scalability.
Palladium–Ruthenium Catalyst for Selective Hydrogenation of Furfural to Cyclopentanol (2018)

Bimetallic Pd–Ru/C catalyst was shown to be much more active in the aqueous-phase hydrogenation of furfural (473 K, 8 MPa) in comparison with both Pd/C and Ru/C catalysts. The enhanced hydrogenation activity manifested itself as an increased yield of cyclopentanol (77%) at a complete conversion of furfural. The observed synergistic effect between palladium and ruthenium in the tested reaction can be related to changes in the electronic state and particle size of supported metals upon interaction with each other and the Pd–Ru alloy formation.
Comparative Study of 660 and 830 nm Photobiomodulation in Promoting Orthodontic Tooth Movement (2019)

<b><i>Objective:</i></b> Photobiomodulation (PBM) can usefully promote wound healing and relieve pain via its biological effects, with a wide range of applications in clinical medicine. The aim of the present study was to investigate the effect of 660 and 830 nm PBM on orthodontic tooth movement. <b><i>Background data:</i></b> PBM is based on the biological effects of diode laser irradiation on tissues, promoting cell proliferation and activity. <b><i>Materials and methods:</i></b> An orthodontic force was applied to the upper right first molars exposed to a 660 and 830 nm PBM (LHH-500I; Beijing Long Hui Heng Medical Science and Technology Development Corporation) on days 0, 1, 2, 3, 4, 5, and 7 for 50 sec with power density of 0.1 W/cm<sup>2</sup> (a beam area of 0.5 cm<sup>2</sup>, radiate power of 0.05 W), energy density of 5 J/cm<sup>2</sup> within 14 days, and a control group with no laser irradiation. Tooth movement was analyzed using a stereomicroscope, the number of osteoclasts determined by tartrate-resistant acid phosphatase (TRAP), and the expression of bone remodeling factors evaluated by immunohistochemistry. <b><i>Results:</i></b> The expression of IL-1β, RANKL, and OPG was significantly stimulated in the 660 and 830 nm groups. The expression of RANKL was significantly higher in the 660 nm group than in the 830 nm group on days 5 and 7; however, there was no significant difference in the expression of OPG and IL-1β between the 660 and 830 nm groups on days 1, 2, 3, 4, 5, 7, and 14. On days 3 and 5, the number of osteoclasts in the 660 nm group was higher than that in the 830 nm group, and the difference was statistically significant. Tooth movement over 14 days was significantly higher in the 660 and 830 nm groups than in the control group, and there was no significant difference between the 660 and 830 nm groups finally. <b><i>Conclusions:</i></b> Both 660 and 830 nm can accelerate the orthodontic tooth movement and promote alveolar bone remodeling on the compression side. Although the difference of tooth movement over 14 days between the two groups was not statistically significant; however, 660 nm PBM to accelerate bone remodeling is stronger than 830 nm PBM at an early stage.
ERK5 is activated by oncogenic BRAF and promotes melanoma growth (2018)

Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the survival of patients with metastatic melanoma in the last few years; however, available treatments are still unsatisfactory. While the role of the BRAF-MEK1/2-ERK1/2 pathway in melanoma is well established, the involvement of mitogen-activated protein kinases MEK5-ERK5 remains poorly explored. Here we investigated the function of ERK5 signaling in melanoma. We show that ERK5 is consistently expressed in human melanoma tissues and is active in melanoma cells. Genetic silencing and pharmacological inhibition of ERK5 pathway drastically reduce the growth of melanoma cells and xenografts harboring wild-type (wt) or mutated BRAF (V600E). We also found that oncogenic BRAF positively regulates expression, phosphorylation, and nuclear localization of ERK5. Importantly, ERK5 kinase and transcriptional transactivator activities are enhanced by BRAF. Nevertheless, combined pharmacological inhibition of BRAFV600E and MEK5 is required to decrease nuclear ERK5, that is critical for the regulation of cell proliferation. Accordingly, combination of MEK5 or ERK5 inhibitors with BRAFV600E inhibitor vemurafenib is more effective than single treatments in reducing colony formation and growth of BRAFV600E melanoma cells and xenografts. Overall, these data support a key role of the ERK5 pathway for melanoma growth in vitro and in vivo and suggest that targeting ERK5, alone or in combination with BRAF-MEK1/2 inhibitors, might represent a novel approach for melanoma treatment.
An Ultra-narrowband, Acoustically Mediated Spintronic Terahertz Emitter (2020)

Narrowband terahertz (THz) radiation are crucial for high-resolution spectral identification, but an intense, narrowband (bandwidth <0.1 THz) THz source driven by a low-cost femtosecond (fs) laser is still missing. Existing fs-laser-driven THz emitters, operating through photoconductive excitation, optical rectification, or ultrafast spin transport (namely, spintronic emitter), are all broadband (bandwidth: 0.3-30 THz). Here, we computationally demonstrate a new type of spintronic emitter that can convert a fs laser pulse into a narrowband THz pulse with an ultranarrow bandwidth of ~0.01 THz. This emitter operates based on the excitation of narrowband THz spin waves in a magnetoelastic film via laser-induced picosecond acoustic pulse, spin current pumping, and spin-to-charge current conversion. Our results also suggest that ultrafast acoustic pulses can enable long-distance (up to millimeters) propagation of THz exchange spin waves that otherwise can only propagate a few nanometers, thus offers new opportunities in the field of THz magnonics as well.
Relationship between serum prolactin levels and protein composition of breast secretions in nonlactating women (1994)

The poten al rela onship between serum PRL levels and protein composi on of breast secre ons was evaluated in 54 premenopausal nonlacta ng women during the luteal phase of their menstrual cycle.Women were classified into four groups according to the presence or absence of breast pathology and to the protein pa ern of their breast secre ons.Type I mammary fluids contain Zn-α2-glycoprotein, apolipoprotein D, and gross cys c disease fluid protein-15, whereas Type II fluids are characterized by the presence of some milk proteins such as lactoferrin, lysozyme, and ol-lactalbumin.Basal serum levels of PRL, as well as of progesterone, LH, FSH, TSH, Tn, and T4 were within normal range, and no significant differences were found between the different groups of women under study.However, a er a TRH s mula on test, the maximum PRL response was significantly higher (P < 0.02) in normal women with Type II secre ons than in those with Type I (64 ± 6.8 µg/L vs. 43.7 ± 3.9 µg/L).Similarly, when PRL concentra ons in pa ents with benign breast disease were considered, those with breast fluids containing milk proteins had a rise in PRL secre on a er TRH s mula on significantly higher (P < 0.05) than those with fluids lacking these proteins (77.1 ± 6.2 vs. 58.8± 5.1 µg/L).These results indicate that the occurrence of milk proteins in breast secre ons from nonlacta ng women is associated with an increase in serum PRL concentra ons a er TRH s mula on, and opens the possibility of using breast fluid protein analysis as a simple and noninvasive procedure for studies on the puta ve role of PRL in the development of benign and malignant breast diseases.This is a pre-copyedited,
Compiling self-adjusting programs with continuations (2008)

Self-adjusting programs respond automatically and efficiently to input changes by tracking the dynamic data dependences of the computation and incrementally updating the output as needed. In order to identify data dependences, previously proposed approaches require the user to make use of a set of monadic primitives. Rewriting an ordinary program into a self-adjusting program with these primitives, however, can be difficult and error-prone due to various monadic and proper-usage restrictions, some of which cannot be enforced statically. Previous work therefore suggests that self-adjusting computation would benefit from direct language and compiler support. In this paper, we propose a language-based technique for writing and compiling self-adjusting programs from ordinary programs. To compile self-adjusting programs, we use a continuation-passing style (cps) transformation to automatically infer a conservative approximation of the dynamic data dependences. To prevent the inferred, approximate dependences from degrading the performance of change propagation, we generate memoized versions of cps functions that can reuse previous work even when they are invoked with different continuations. The approach offers a natural programming style that requires minimal changes to existing code, while statically enforcing the invariants required by self-adjusting computation. We validate the feasibility of our proposal by extending Standard ML and by integrating the transformation into MLton, a whole-program optimizing compiler for Standard ML. Our experiments indicate that the proposed compilation technique can produce self-adjusting programs whose performance is consistent with the asymptotic bounds and experimental results obtained via manual rewriting (up to a constant factor).
A Generalization Performance Study Using Deep Learning Networks in Embedded Systems (2021)

Deep learning techniques are being increasingly used in the scientific community as a consequence of the high computational capacity of current systems and the increase in the amount of data available as a result of the digitalisation of society in general and the industrial world in particular. In addition, the immersion of the field of edge computing, which focuses on integrating artificial intelligence as close as possible to the client, makes it possible to implement systems that act in real time without the need to transfer all of the data to centralised servers. The combination of these two concepts can lead to systems with the capacity to make correct decisions and act based on them immediately and in situ. Despite this, the low capacity of embedded systems greatly hinders this integration, so the possibility of being able to integrate them into a wide range of micro-controllers can be a great advantage. This paper contributes with the generation of an environment based on Mbed OS and TensorFlow Lite to be embedded in any general purpose embedded system, allowing the introduction of deep learning architectures. The experiments herein prove that the proposed system is competitive if compared to other commercial systems.
Valence band states and polarized optical emission from nonpolar and semipolar III–nitride quantum well optoelectronic devices (2014)

Nonpolar and semipolar III–nitride quantum wells (QWs) and devices have been extensively studied due to their unique valence band (VB) structure and polarized optical emission. Unlike conventional c-plane oriented III–nitride QWs, the low crystal symmetry and unbalanced biaxial stress in nonpolar and semipolar QWs separates the topmost VBs and gives rise to polarized optical emission. Since the first experimental reports on nonpolar devices, research on this topic has progressed very rapidly and has covered nonpolar m-plane and a-plane QWs and devices as well as semipolar , , and QWs and devices. Issues such as strain, plane inclination angle (with respect to the c-plane), indium composition, temperature, and their impact on QW VB structure and device performance have been extensively studied. In this paper we review the physical background and theoretical analysis of the VB states and polarized optical emission of nonpolar and semipolar structures and discuss their potential impacts on optoelectronic devices. Experimental results for nonpolar and semipolar light-emitting diodes and laser diodes will be covered along with additional discussions on the potential applications and challenges related to their unique physical properties.
Yet another acoustic representation of speech sounds (2004)

This paper proposes yet another representation of speech sounds. The proposed speech modeling can remove both multiplicative and linear transformational distortion from speech theoretically. It means that speech sounds are represented without being affected by any static distortion inevitably involved in production, encoding, transmission, decoding, and hearing processes, such as differences in vocal tract length, gender, age, microphone, room, line, auditory characteristics, and so on. The method acoustically models not individual phones but their entire system, where only acoustic interrelation embedded in all the kinds of phones is focused. Since the method provides us with no absolute acoustic properties of phones, it cannot recognize or synthesize even a single phone. On the contrary, the proposed method is shown to be able to be applied to pronunciation assessment effectively and reliably, where the proficiency of pronunciation is estimated without using acoustic models of the individual phones directly in the matching.