gebhart/patrepeval huggingface dataset:
Increased Fibronectin Deposition in Embryonic Hearts of Retinol-Binding Protein–Null Mice (2003)

Precise regulation of retinoid levels is critical for normal heart development. Retinol-binding protein (RBP), an extracellular retinol transporter, is strongly secreted by cardiogenic endoderm. This study addresses whether RBP gene ablation affects heart development. Despite exhibiting an >85% decrease in serum retinol, adult RBP-null mice are viable, breed, and have normal vision when maintained on a vitamin A-sufficient diet. Comparison of RBP-null with wild-type (WT) hearts from embryos at day 9.0 (E9.0) through E12.5 revealed an RBP-null phenotype similar to that of other retinoid-deficient models. At an early stage, RBP-null hearts display retarded trabecular development, which recovers by E9.5. This is accompanied at E9.5 and E10.5 by precocious differentiation of subepicardial cardiac myocytes. Most remarkably, RBP-null hearts display augmented deposition of fibronectin protein in the cardiac jelly at E9.0 through E10.5 and in the outflow tract at E12.5. This phenomenon, which was detected by immunohistochemistry and Western blotting without increased fibronectin transcript levels, is accompanied by increased numbers of mesenchymal cells in the outflow tract but not in the atrioventricular canal. RBP-null cardiac myocytes, especially in the subepicardial layer, display increased cell proliferation. This phenotype may present a model of subclinical retinoid insufficiency characterized by alteration of an extracellular matrix component and altered cellular differentiation and proliferation, changes that may have functional consequences for adult cardiac function. This murine model may have relevance to fetal development in human populations with inadequate retinoid intake.
Mobile Semantic Data Exchange in Ad Hoc Networks using Distributed Profiles (2006)

Collecting relevant information from a heterogeneous set of data resources is a challenging problem. Moreover, the storage and search for semantic data is even more complex in mobile environments. In this paper we present an approach how to collect semantic information by underlying profile settings. We define several profile types and levels where the user's interests are stored. Information retrieval is then executed according to the profile settings. Distributed profiles for mobile semantic data exchange can personalize the exchanged information in business settings. This leads to effective data transmission with regard to the mobile (device) context and the business environment, the user is exposed to. Our realization of a prototype confirms the effective semantic data exchange. The evaluation of dynamic profile settings in ad hoc network scenarios verifies our approach experimentally.
Introduction (2022)

Abstract This chapter introduces the theoretical notion of a concept. Concepts are bodies of knowledge that are quickly accessed in various situations. Sorting the world into categories enables us to recall and use information that we have gathered over time. We use concepts to recognize patterns, draw inferences, make decisions, and understand word meanings. In this chapter, the author explains why researchers think that our concepts might be grounded in action, emotion, and perception systems and why abstract concepts threaten this proposal. A road map for the arguments contained in the book is provided. The author contends that researchers need to explore the diverse sources of grounding, the influence of higher-level representations, and the ways in which concepts are shaped by social factors and situations.
Target‐oriented AVO inversion of North Sea data (1992)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1992Target‐oriented AVO inversion of North Sea dataAuthors: Martin LandrøJan HelgesenFrancois ChapelIsabell PicartMartin LandrøIKU, Norway, Jan HelgesenIKU, Norway, Francois ChapelELF Aquitaine, France, and Isabell PicartELF Aquitaine, Francehttps://doi.org/10.1190/1.1822241 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1822241FiguresReferencesRelatedDetailsCited byNet pay delineation of gas sand using integrated target‐oriented prestacke elastic waveform inversionG. S. Pan, C. Y. Young, and J. P. Castagna10 February 2005 SEG Technical Program Expanded Abstracts 1992 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 1992 Pages: 1410 publication data© 1992 Copyright © 1992 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Martin Landrø, Jan Helgesen, Francois Chapel, and Isabell Picart, (1992), "Target‐oriented AVO inversion of North Sea data," SEG Technical Program Expanded Abstracts : 870-873. https://doi.org/10.1190/1.1822241 Plain-Language Summary PDF DownloadLoading ...
Optimized LTE Cell Planning With Varying Spatial and Temporal User Densities (2015)

Base station (BS) deployment in cellular networks is one of the fundamental problems in network design. This paper proposes a novel method for the cell planning problem for fourth-generation (4G) cellular networks using metaheuristic algorithms. In this approach, we aim to satisfy both cell coverage and capacity constraints simultaneously by formulating an optimization problem that captures practical planning aspects. The starting point of the planning process is defined through a dimensioning exercise that captures both coverage and capacity constraints. Afterward, we implement a metaheuristic algorithm based on swarm intelligence (e.g., particle swarm optimization or the recently proposed gray-wolf optimizer) to find suboptimal BS locations that satisfy both problem constraints in the area of interest, which can be divided into several subareas with different spatial user densities. Subsequently, an iterative approach is executed to eliminate eventual redundant BSs. We also perform Monte Carlo simulations to study the performance of the proposed scheme and compute the average number of users in outage. Next, the problems of green planning with regard to temporal traffic variation and planning with location constraints due to tight limits on electromagnetic radiations are addressed, using the proposed method. Finally, in our simulation results, we apply our proposed approach for different scenarios with different subareas and user distributions and show that the desired network quality-of-service (QoS) targets are always reached, even for large-scale problems.
Spatially-Attentive Patch-Hierarchical Network for Adaptive Motion Deblurring (2020)

This paper tackles the problem of motion deblurring of dynamic scenes. Although end-to-end fully convolutional designs have recently advanced the state-of-the-art in non-uniform motion deblurring, their performance-complexity trade-off is still sub-optimal. Existing approaches achieve a large receptive field by increasing the number of generic convolution layers and kernel-size, but this comes at the expense of of the increase in model size and inference speed. In this work, we propose an efficient pixel adaptive and feature attentive design for handling large blur variations across different spatial locations and process each test image adaptively. We also propose an effective content-aware global-local filtering module that significantly improves performance by considering not only global dependencies but also by dynamically exploiting neighbouring pixel information. We use a patch-hierarchical attentive architecture composed of the above module that implicitly discovers the spatial variations in the blur present in the input image and in turn, performs local and global modulation of intermediate features. Extensive qualitative and quantitative comparisons with prior art on deblurring benchmarks demonstrate that our design offers significant improvements over the state-of-the-art in accuracy as well as speed.
Laser Programmable Vias For Reconfiguration Of Integrated Circuits (1989)

The post process reconfiguration of 2 metal layers integrated VLSI circuits, achieved by via formation in intermetal oxide, was studied with doubled frequency YAG laser (532 nm). The creation of vias is experimented on test patterns placed within 3 circuits of different technology. Vias thus formed are created by thermal effect with mechanism of fusion and by mechanical explosion in the insulating layers. No damage was verified by electrical measurements and SEM cross section studies. For metallizations containing refractory metals, the via yields reached 100 % for patterns of 2.6 μm x 4.7 μm. The feasibility of this process has been established for recovering area of 3 μm x 3 μm. Via resistance was measured to be a few Ohms without resorting to post process annealing and the minimum breakdown current was found to be 150 mA. A via is creatable in a metallic line without damaging others lines as close as 1.5 μm. Reliability test of vias at 125°C and 5 mA showedno failure after 1000 hours. Consequently, creation of vias by laser has been shown to be achievable in a metal interconnection environment conforming to VLSI minimum design rules of 1.2 μm.
T Cell Receptor Gene Therapy for Autoimmune Diseases (2007)

The current quality of autoimmune disease treatments is not satisfactory in regard to efficacy and safety. Antigen-specific immunotherapy is a future therapy that could achieve maximal efficacy with minimal adverse effects. T cells are essential components in antigen-specific immunity. However, we do not have a sufficient strategy for manipulating antigen-specific T cells. We propose that T cell receptor (TCR) gene transfer is a hopeful approach for antigen-specific immunotherapy. We confirmed the efficacy of TCR gene therapy in animal models of systemic autoimmune disease and arthritis. In lupus-prone NZB/W F1 mice, nucleosome-specific TCR and CTLA4Ig transduced cells suppressed autoantibody production and nephritis development. In the therapeutic experiment of collagen-induced arthritis (CIA), arthritis-related TCRs were isolated from single T cells accumulating in the arthritis site. Arthritis-related TCR and TNFRIg transduced cells or TCR and Foxp3 transduced cells suppressed arthritis progression and bone destruction. Therefore, engineered antigen-specific cells manipulated to express appropriate functional genes could be applied to specific immunotherapy.
Technique for achieving wideband 1/2 regenerativefrequency division using LSB-SSB modulation (1995)

An approach for achieving regenerative frequency division in a frequency range in excess of one decade is described. A lower sideband-single sideband (LSB-SSB) modulator is used in lieu of the classical second-order modulator, to reject the upper sideband in a wide frequency range. Simulation results are presented to illustrate the validity of the concept.
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (2001)

An approximately threefold increase in glycogenolytic activity of the neutral alpha-1,4-glucosidase and a twofold increase in the same activity of the acid isoform have been found in extracts of anaplastic astrocytoma and glioblastoma multiforme tumors of brain tissue. "Maltase activity" of the respective enzymes increased by 60-80% in both kinds of tumor extracts. However a significant decrease in a-amylase and almost complete disappearance of phosphorylase activities have also been found in both kinds of tumors.
Design of a High–Resolution Surface Electromyogram (EMG) Conditioning Circuit (2012)

The electromyogram -- the electrical activity of skeletal muscle -- finds useful applications in many fields, such as biomechanics, rehabilitation medicine, neurology, gait analysis, exercise physiology, pain management, orthotics, prosthetic device control, even unvoiced speech recognition and man--machine interfaces. An electromyogram signal detection and conditioning circuit has been designed by Prof. E. Clancy in 2003. The goal of this project was to investigate technological advances since 2003 and design a new electromyogram signal conditioning circuit that would have at least the same performance characteristics, would be reduced in size and power and be possible to manufacture and maintain in an academic setting.
Aniline derivatives of tetrakis(hydromethyl)phosphonium chloride (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAniline derivatives of tetrakis(hydromethyl)phosphonium chlorideArlen W. Frank and George L. Drake Jr.Cite this: J. Org. Chem. 1972, 37, 17, 2752–2755Publication Date (Print):August 1, 1972Publication History Published online1 May 2002Published inissue 1 August 1972https://pubs.acs.org/doi/10.1021/jo00982a030https://doi.org/10.1021/jo00982a030research-articleACS PublicationsRequest reuse permissionsArticle Views344Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
S and G<sub>2</sub> Phase Roles for Cdk2 Revealed by Inducible Expression of a Dominant-Negative Mutant in Human Cells (2001)

Cyclin-dependent kinase 2 (Cdk2) is essential for initiation of DNA synthesis in higher eukaryotes. Biochemical studies in Xenopus egg extracts and microinjection studies in human cells have suggested an additional function for Cdk2 in activation of Cdk1 and entry into mitosis. To further examine the role of Cdk2 in human cells, we generated stable clones with inducible expression of wild-type and dominant-negative forms of the enzyme (Cdk2-wt and Cdk2-dn, respectively). Both exogenous proteins associated efficiently with endogenous cyclins. Cdk2-wt had no apparent effect on the cell division cycle, whereas Cdk2-dn inhibited progression through several distinct stages. Cdk2-dn induction could arrest cells at the G1/S transition, as previously observed in transient expression studies. However, under normal culture conditions, Cdk2-dn induction primarily arrested cells with S and G2/M DNA contents. Several observations suggested that the latter cells were in G2 phase, prior to the onset of mitosis: these cells contained uncondensed chromosomes, low levels of cyclin B-associated kinase activity, and high levels of tyrosine-phosphorylated Cdk1. Furthermore, Cdk2-dn did not delay progression through mitosis upon release of cells from a nocodazole block. Although the G2 arrest imposed by Cdk2-dn was similar to that imposed by the DNA damage checkpoint, the former was distinguished by its resistance to caffeine. These findings provide evidence for essential functions of Cdk2 during S and G2 phases of the mammalian cell cycle.
A national survey of medical risk assessment instruction in general practice residency programs: Part III (1993)

This is the third of a three‐part series reporting a national survey of general practice residency directors and their evaluation of the medical risk assessment (MRA) instruction curriculum in their programs. The purpose of Part III was to report the program directors' narrative comments in response to six essay‐style questions regarding problems, suggestions, and innovations encountered in their efforts. Availability of physician faculty was the most frequently mentioned problem in providing MRA instruction for general practice residents. Defining and communicating goals and objectives were also of major concern. Proposed solutions included attempts to recruit additional physician faculty and improved supervision and management of program activities, especially off‐service rotations. There was no consensus as to what future modifications the Commission on Dental Accreditation should make in its approach to teaching MRA as defined in Standard 14. The majority of responses indicated a desire to decrease total experience, especially in physical examination requirements other than head and neck
Influence of dimethylsulfoxide on transcription by bacteriophage T3‐induced RNA polymerase (1981)

Abstract Dimethylsulfoxide (DMSO) Abbreviations used: Dimethylsulfoxide DMSO, polyvinyl sulfate PVS, nucleoside triphosphate NTP up to 25% (v/v) does not cause irreversible alterations of T3 DNA at 42.5°C as assayed by transcription with T3‐specific RNA polymerase. The optimal temperature for the formation of polyanion‐resistant ternary complexes of the enzyme, T3 DNA, and nascent RNA chains is lowered by 12.5°C in the presence of 20% (v/v) DMSO. The same solvent concentration, however, decreases the temperature optimal for T3 RNA chain elongation by only 2.5°C, indicating that DMSO preferably affects the initiation of T3 RNA synthesis. DMSO accelerates the loss of T3‐specific RNA polymerase activity at 42.5°C. Nevertheless, the speed with which the binary complexes between the phage RNA polymerase and DNA are inactivated by heat (42.5°C) is not altered in presence of 20% (v/v) DMSO. The binding of T3‐induced RNA polymerase to T3 DNA in polyanion‐resistant ternary complexes is influenced by DMSO which makes the enzyme accessible to the inhibitory action of polyvinyl sulfate. Elongation of T3 RNA chains is slowed down by 20% (v/v) DMSO.
SIRT1 and SIRT2: emerging targets in neurodegeneration (2013)

Sirtuins are NAD-dependent protein deacetylases known to have protective effects against age-related diseases such as cancer, diabetes, cardiovascular and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function. While SIRT1 has been extensively investigated due to its initial connection with lifespan extension and involvement in calorie restriction, important biological and therapeutic roles of other sirtuins have only recently been recognized. Here, we review the potential roles and effects of SIRT1 and SIRT2 in neurodegenerative diseases. We discuss different functions and targets of SIRT1 and SIRT2 in a variety of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's Disease (HD). We also cover the role of SIRT1 in neuronal differentiation due to the possible implications in neurodegenerative conditions, and conclude with an outlook on the potential therapeutic value of SIRT1 and SIRT2 in these disorders.
Site Dependency of the High Conductivity of Ga<sub>2</sub>In<sub>6</sub>Sn<sub>2</sub>O<sub>16</sub>: The Role of the 7-Coordinate Site (2015)

The 6-coordinated cation site is the fundamental building block of the most effective transparent conducting oxides. Ga2In6Sn2O16, however, maintains 4-, 6-, 7-, and 8-coordinated cation sites and still exhibits desirable transparency and high conductivity. To investigate the potential impact of these alternative sites, we partially replace the Sn in Ga2In6Sn2O16 with Ti, Zr, or Hf and use a combined approach of density functional theory-based calculations, X-ray diffraction, and neutron diffraction to establish that the substitution occurs preferentially on the 7-coordinate site. In contrast to Sn, the empty d orbitals of Ti, Zr, and Hf promote spd covalency with the surrounding oxygen, which decreases the conductivity. Pairing the substitutional site preference with the magnitude of this decrease demonstrates that the 7-coordinate site is the major contributor to conductivity. The optical band gaps, in contrast, are shown to be site-independent and composition-dependent. After all 7-coordinate Sn has been replaced, the continued substitution of Sn results in the formation of a 7-coordinate In antisite or replacement of 6-coordinate Sn, depending on the identity of the d0 substitute.
Function and Immunochemistry of Prekallikrein-High Molecular Weight Kininogen Complex in Plasma (1980)

Plasma from individuals with high molecular weight (HMW) kininogen deficiency has been reported to be deficient in prekallikrein as measured by radial immunodiffusion, prekallikrein coagulant activity, and/or kaolin-activated arginine esterase activity. The discovery that prekallikrein and HMW kininogen circulate as a complex in plasma led us to reevaluate the antigenic and functional properties of prekallikrein in HMW kininogen-deficient plasma as well as in normal plasma. The low prekallikrein antigen level in an individual with HMW kininogen deficiency was corrected to the normal range (80-95%) by the addition of 0.2 U/ml of purified HMW kininogen. A similar increase in apparent prekallikrein antigen was observed when purified prekallikrein and HMW kininogen were combined. The correction of the apparent prekallikrein defect in this HMW kininogen-deficient plasma coincided with the formation of a prekallikrein-HMW kininogen complex as demonstrated by immunoelectrophoresis. Similar findings were demonstrated with purified prekallikrein and HMW kininogen by immunoelectrophoresis as well as crossed immunoelectrophoresis. The coagulant activity in HMW kininogen-deficient plasma was increased in a dose-dependent manner by the addition of HMW kininogen, reaching 85% of normal level at a concentration of 0.2 U/ml. Kaolin-activated arginine esterase activity (kallikrein) in HMW kininogen-deficient plasma was fully corrected when HMW kininogen was added to the deficient plasma after depletion of kallikrein inhibitors. The functional and antigenic concentration of prekallikrein in plasma from four other HMW kininogen-deficient individuals was similarly corrected to normal after adding HMW kininogen. Addition of HMW kininogen increased the apparent prekallikrein activity in native normal plasma (as measured by esterase activity) but not in normal plasma in which inhibitors were inactivated. The apparent prekallikrein antigen concentration (as measured by radial immunodiffusion or electroimmunodiffusion) increased upon addition of HMW kininogen. Immunoelectrophoresis as well as gel filtration of normal plasma revealed the presence of free prekallikrein (17-38% of the total) in addition to the HMW kininogen-prekallikrein complex previously reported. This study emphasizes the influence of HMW kininogen on both functional and immunologic determinations of prekallikrein.
Competencia y concentración en el sistema financiero en el Perú (2010)

La mirada convencional de los no especialistas es que la alta concentración en un mercado implica necesariamente falta de competencia, por ello se demanda medidas para evitar la alta concentración. La teoría económica sugiere muchas razones para que este vínculo no exista. En este documento analizamos 7 productos bancarios en el Perú y mostramos, a través de la estimación econométrica de un modelo de demanda residual corregido por la calidad del producto que ofrece cada institución financiera, que en efecto la alta concentración no implica falta de competencia. Por el contrario, los datos sugieren que en la mayoría de los mercados la competencia aumentó.