gebhart/patrepeval huggingface dataset:
Iterative Learning Control With Time-Delay Compensation: An Application to Twin-Roll Strip Casting (2020)

In this article, we propose an iterative learning control (ILC) algorithm for a class of periodic processes with a variable time-delay that is greater than one iteration of the process. We propose a definition of the time delay as the sum of an integer and a residual such that the two components can be estimated separately. This structure enables the derivation of a stability law for an ILC algorithm that is a function of the delay-estimation error. Additional remarks are given regarding the steady-state performance of the combined time-delay-estimation and ILC algorithm. The proposed algorithm is then applied to a twin-roll strip casting process. We demonstrate the sensitivity of the ILC algorithm to the time-delay-estimation error through simulation results and define an upper bound for the time-delay-estimation error that can be tolerated before the ILC algorithm begins to amplify the disturbance. We then validate the combined time-delay-estimation and ILC algorithm's performance using experimental process data from an industrial twin-roll strip casting process.
Olefin oligomerization for the production of fuels and petrochemicals (2010)

Catalytic oligomerizations of light olefins have been industrially applied both in petroleum refineries, mainly for motor-fuel production, and in petrochemical industry for the manufacture of large scale chemical intermediates or fine chemicals. The oligomerization reaction can be catalyzed by means of homogeneous or heterogeneous catalytic systems. Both technologies present advantages and limitations. Biphasic liquid-liquid catalysis appears as and alternative interesting approach. (orig.)
Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge (2020)

The optimal protective immunity against <i>Chlamydia trachomatis</i> (<i>C.t.)</i> is still not fully resolved. One of the unresolved issues concerns the importance of resident immunity, since a recent study showed that optimal protection against a transcervical (TC) infection required genital tissue-resident memory T cells. An important question in the <i>Chlamydia</i> field is therefore if a parenteral vaccine strategy, inducing only circulating immunity primed at a nonmucosal site, should be pursued by <i>Chlamydia</i> vaccine developers. To address this question we studied the protective efficacy of a parenteral <i>Chlamydia</i> vaccine, formulated in the Th1/Th17 T cell-inducing adjuvant CAF01. We found that a parenteral vaccination induced significant protection against a TC infection and against development of chronic pathology. Protection correlated with rapid recruitment of Th1/Th17 T cells to the genital tract (GT), which efficiently prevented infection-driven generation of low quality Th1 or Th17 T cells, and instead maintained a pool of high quality multifunctional Th1/Th17 T cells in the GT throughout the infection. After clearance of the infection, a pool of these cells settled in the GT as tissue-resident Th1 and Th17 cells expressing CD69 but not CD103, CD49d, or CCR7, where they responded rapidly to a reinfection. These results show that a nonmucosal parenteral strategy inducing Th1 and Th17 T cells mediates protection against both infection with <i>C.t</i>. as well as development of chronic pathology, and lead to post-challenge protective tissue-resident memory immunity in the genital tract.
A NOVEL METHOD FOR THE REMOVAL OF TRACE CONCENTRATION OF ELEMENTAL MERCURY FROM UTILITY EMISSIONS (2002)

A new technique for removal of elemental mercury from emissions of coal-fired utilities was investigated. The key idea is to selectively photo ionize the mercury atoms. A strong electric field gradient then drags them to the negative plate where they can be collected and removed.
Compensation of the Impact of Interference Mitigation by Pulse Blanking in OFDM Systems (2009)

When pulsed interference is mitigated by means of pulse blanking, interference is reduced significantly. However, at the same time certain fractions of the useful orthogonal frequency-division multiplexing (OFDM) signal are erased. Consequently, only moderate improvements are achieved with pulse blanking. When representing the pulse blanking operation as multiplication with a rectangular window exhibiting notches at the positions where blanks are inserted, it becomes obvious, that pulse blanking mainly leads to inter-carrier interference (ICI). In this paper, the compensation of the impact of pulse blanking is proposed by reconstructing and subtracting ICI. The required shape of the subcarrier spectra is derived from the pulse blanking window. For an estimation of the transmitted data symbols and the channel coefficients of each subcarrier an iterative receiver structure is proposed. Simulation results at hand of a realistic interference scenario show that with perfect channel estimation and known data symbols the impact of pulse blanking can be reduced to a small loss in signal-to-noise ratio resulting from the energy loss due to erasing a certain fraction of the OFDM signal. With real channel estimation and estimated data symbols, the ideal case with perfect channel estimation and known data symbols is approached by 1.2 dB after only three iterations.
Optoelectronic VLSI switching chip with greater than 4000 optical I/O based on flip chip bonding of GaAs-AlGaAs MQW modulators and detectors to silicon CMOS (1996)

Summary form only given. Optical interconnections between electronic devices is expected to alleviate the communication bottleneck that exists in today's electronic switching and computing systems. A particularly attractive approach is to integrate the optical detectors and modulators or sources directly onto electronic circuitry. We believe we present the first high speed optoelectronic VLSI switching chip using this technology. The circuit has 4096 optical detectors, 256 optical modulators, 140 K FETs. The circuit implements 16 16/spl times/16 fully interconnected switches.
Plastic-based distributed feedback laser biosensors in microplate format (2011)

We characterized the uniformity and sensitivity of the distributed feedback laser biosensors in 96-well microplate format, with a thickness standard deviation of ~35 nm. An assay was also used to demonstrate its biomolecule detection ability.
Negative Permeability-Based Electrically Small Antennas (2008)

The goal of this letter is to present the behavior of mu-negative (MNG) metamaterial-based electrically small antennas. The Green's function analysis is applied to characterize the performance of a hemispherical negative permeability (MNG) resonator excited by a slot aperture. The method of moment (MoM) is used to obtain the current distribution over the source excitation. It is illustrated how a resonator composed of negative permeability medium can successfully establish a small antenna element. For small-size structure , the approximated-form Green's function demonstrates the relation between the resonant frequencies and the material parameters. The obtained results are integrated into the design of a MNG slab radiator. The radiation performance of a slab resonator is detailed using a finite difference time domain (FDTD) full wave analysis. The obtained observations may provide road maps for the future design of metamaterial-based subwavelength antennas.
Solid State Lithium Cyanocobaltates with a High Capacity for Reversible Dioxygen Binding: Synthesis, Reactivity, and Structures (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid State Lithium Cyanocobaltates with a High Capacity for Reversible Dioxygen Binding: Synthesis, Reactivity, and StructuresDorai Ramprasad, Guido P. Pez, Brian H. Toby, Thomas J. Markley, and Ronald M. PearlsteinCite this: J. Am. Chem. Soc. 1995, 117, 43, 10694–10701Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://doi.org/10.1021/ja00148a011Request reuse permissionsArticle Views487Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Ingredients analysis of aqueous solutions and food products with reflection THz spectroscopy (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text P. U. Jepsen, U. Møller, D. Cooke, and J. R. Folkenberg, "Ingredients analysis of aqueous solutions and food products with reflection THz spectroscopy," in Frontiers in Optics 2007/Laser Science XXIII/Organic Materials and Devices for Displays and Energy Conversion, OSA Technical Digest (CD) (Optica Publishing Group, 2007), paper LThC1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Role of Arginine in Development of Biopharmaceuticals (2010)

Production, formulation and characterization of proteins play a major role in biotechnology industries. We have shown that aqueous arginine solution increases the solubility of proteins in formulation and purification, suppresses aggregation during refolding and storage and improves performance of column chromatography. Acidic arginine solution now finds application for virus inactivation. I will summarize these various effects of arginine on proteins and viruses and describe the current knowledge of the mechanism of the effects of arginine.
A phase 1/2, open-label assessment of the safety, tolerability, and efficacy of transdermal cannabidiol (ZYN002) for the treatment of pediatric fragile X syndrome (2019)

ANZCTR, ACTRN12617000150347 Registered 27 January 2017.
Characterization of Heavy Petroleum Saturates by Laser Desorption Silver Cationization and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (2013)

A method was developed for the analysis of high-boiling petroleum saturates by laser desorption and silver cationization (LDI-Ag) coupled to Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). Commercial polywax standards, petroleum vacuum gas oil (VGO), and vacuum resid (VR) were successfully analyzed with a carbon number span from 30 to 100. Representative model compounds were studied to evaluate relative sensitivity of the ionization method. “Soft” ionizations have been observed for all hydrocarbon types, generating primarily M + Ag+ • ions. Because of the existence of silver isotopes, an ultrahigh mass resolution [e.g., resolving power (RP) > 65 000 at mass ∼ 1000 Da] is found necessary to resolve the key mass overlap (107AgH2/109Ag doublet; ΔM ∼ 16 mDa). Petroleum saturate composition was arranged by homologous series with a general chemical formula (CcH2c + Z), where c stands for the carbon number and Z is generally referred as the hydrogen deficiency index. A comparison of Z number distributions between VGO and VR saturates revealed significant differences in the compositions and structures. The Z number of VGO ranges from 2 to −12, corresponding to 0–7 naphthenic rings, respectively. This result is consistent with the prior knowledge on VGO composition from conventional analytical methods. For VR saturates, Z numbers ranging from 2 to −24 (0–13 naphthenic rings) have been observed. Because olefin and aromatic contents in saturate samples are very low, the large Z number (Z less than −12) are attributed to the presence of high-order naphthenic ring structures (>7 ring naphthenes).
Molecular Cloning and Characterization of SmLIM, a Developmentally Regulated LIM Protein Preferentially Expressed in Aortic Smooth Muscle Cells (1996)

Differentiated, quiescent vascular smooth muscle cells assume a dedifferentiated, proliferative phenotype in response to injury, one of the hallmarks of arteriosclerosis. Members of the LIM family of zinc-finger proteins are important in the differentiation of various cells including striated muscle. We describe here the molecular cloning and characterization of a developmentally regulated smooth muscle LIM protein, SmLIM, that is expressed preferentially in the rat aorta. This 194-amino acid protein has two LIM domains, and comparisons of rat SmLIM with its mouse and human homologues reveal high levels of amino acid sequence conservation (100 and 99%, respectively). SmLIM is a nuclear protein and maps to human chromosome 3. SmLIM mRNA expression was high in aorta but not in striated muscle and low in other smooth muscle tissues such as intestine and uterus. In contrast with arterial tissue, SmLIM mRNA was barely detectable in venous tissue. The presence of SmLIM expression within aortic smooth muscle cells was confirmed by in situ hybridization. In vitro, SmLIM mRNA levels decreased by 80% in response to platelet-derived growth factor-BB in rat aortic smooth muscle cells. In vivo, SmLIM mRNA decreased by 60% in response to vessel wall injury during periods of maximal smooth muscle cell proliferation. The down-regulation of SmLIM by phenotypic change in vascular smooth muscle cells suggests that it may be involved in their growth and differentiation.
MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome (2016)

Fragile X syndrome, the most common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein (FMRP). However, the mechanism remains unclear, and effective treatment is lacking. We show that loss of FMRP leads to activation of adult mouse neural stem cells (NSCs) and a subsequent reduction in the production of neurons. We identified the ubiquitin ligase mouse double minute 2 homolog (MDM2) as a target of FMRP. FMRP regulates Mdm2 mRNA stability, and loss of FMRP resulted in elevated MDM2 mRNA and protein. Further, we found that increased MDM2 expression led to reduced P53 expression in adult mouse NSCs, leading to alterations in NSC proliferation and differentiation. Treatment with Nutlin-3, a small molecule undergoing clinical trials for treating cancer, specifically inhibited the interaction of MDM2 with P53, and rescued neurogenic and cognitive deficits in FMRP-deficient mice. Our data reveal a potential regulatory role for FMRP in the balance between adult NSC activation and quiescence, and identify a potential new treatment for fragile X syndrome.
Flexible ferroelectret field-effect transistor for large-area sensor skins and microphones (2006)

Ferroelectrets generate an electric field large enough to modulate the conductance of the source-drain channel of a thin-film field-effect transistor. Integrating a ferroelectret with a thin-film transistor produces a ferroelectret field-effect transistor. The authors made such transistors by laminating cellular polypropylene films and amorphous silicon thin-film transistors on polyimide substrates. They show that these ferrroelectret field-effect transistors respond in a static capacitive or dynamic piezoelectric mode. A touch sensor, a pressure-activated switch, and a microphone are demonstrated. The structure can be scaled up to large-area flexible transducer arrays, such as roll-up steerable compliant sensor skin.
Trisubstituted Pyrazolopyrimidines as Novel Angiogenesis Inhibitors (2013)

Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR. We have recently identified cyclin-dependent kinase 5 (Cdk5) as novel alternative and pharmacologically accessible target in the context of angiogenesis. In the present work we demonstrate that trisubstituted pyrazolo[4,3-d]pyrimidines constitute a novel class of compounds which potently inhibit angiogenesis. All seven tested compounds inhibited endothelial cell proliferation with IC(50) values between 1 and 18 µM. Interestingly, this seems not to be due to cytotoxicity, since none of them showed acute cytotoxic effects on endothelial cells at a concentration of 10 µM,. The three most potent compounds (LGR1404, LGR1406 and LGR1407) also inhibited cell migration (by 27, 51 and 31%, resp.), chemotaxis (by 50, 70 and 60% in accumulative distance, resp.), and tube formation (by 25, 60 and 30% of total tube length, resp.) at the non-toxic concentration of 10 µM. Furthermore, angiogenesis was reduced in vivo in the CAM assay by these three compounds. A kinase selectivity profiling revealed that the compounds prevalently inhibit Cdk2, Cdk5 and Cdk9. The phenotype of the migrating cells (reduced formation of lamellipodia, loss of Rac-1 translocation to the membrane) resembles the previously described effects of silencing of Cdk5 in endothelial cells. We conclude that especially LGR1406 and LGR1407 are highly attractive anti-angiogenic compounds, whose effects seem to largely depend on their Cdk5 inhibiting properties.
NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with μ-Opioid Agonist Activity (2012)

A novel series of benzimidazole designed multiple ligands (DMLs) with activity at the neuronal nitric oxide synthase (nNOS) enzyme and the μ-opioid receptor was developed. Targeting of the structurally dissimilar heme-containing enzyme and the μ-opioid GPCR was predicated on the modulatory role of nitric oxide on μ-opioid receptor function. Structure-activity relationship studies yielded lead compound 24 with excellent nNOS inhibitory activity (IC50 = 0.44 μM), selectivity over both endothelial nitric oxide synthase (10-fold) and inducible nitric oxide synthase (125-fold), and potent μ-opioid binding affinity, K i = 5.4 nM. The functional activity as measured in the cyclic adenosine monosphospate secondary messenger assay resulted in full agonist activity (EC50 = 0.34 μM). This work represents a novel approach in the development of new analgesics for the treatment of pain.
A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers (2015)

Immortality is an essential characteristic of human carcinoma cells. We recently developed an efficient, reproducible method that immortalizes human mammary epithelial cells (HMEC) in the absence of gross genomic changes by targeting 2 critical senescence barriers. Consistent transcriptomic changes associated with immortality were identified using microarray analysis of isogenic normal finite pre-stasis, abnormal finite post-stasis, and immortal HMECs from 4 individuals. A total of 277 genes consistently changed in cells that transitioned from post-stasis to immortal. Gene ontology analysis of affected genes revealed biological processes significantly altered in the immortalization process. These immortalization-associated changes showed striking similarity to the gene expression changes seen in The Cancer Genome Atlas (TCGA) clinical breast cancer data. The most dramatic change in gene expression seen during the immortalization step was the downregulation of an unnamed, incompletely annotated transcript that we called MORT, for mortality, since its expression was closely associated with the mortal, finite lifespan phenotype. We show here that MORT (ZNF667-AS1) is expressed in all normal finite lifespan human cells examined to date and is lost in immortalized HMEC. MORT gene silencing at the mortal/immortal boundary was due to DNA hypermethylation of its CpG island promoter. This epigenetic silencing is also seen in human breast cancer cell lines and in a majority of human breast tumor tissues. The functional importance of DNA hypermethylation in MORT gene silencing is supported by the ability of 5-aza-2'-deoxycytidine to reactivate MORT expression. Analysis of TCGA data revealed deregulation of MORT expression due to DNA hypermethylation in 15 out of the 17 most common human cancers. The epigenetic silencing of MORT in a large majority of the common human cancers suggests a potential fundamental role in cellular immortalization during human carcinogenesis.
Streptomyces laurentii, a new species producing thiostrepton. (1977)

The taxonomic description of Streptomyces laurentii, a new species related to but distinguishable from the S. fradiae group, is presented. This new species produces thiostrepton but bears no taxonomic relationship to the known producers of the antibiotic: S. azureus, S. hawaiiensis, and Streptomyces X-14b.
<i>HLA-C</i>–Dependent Prevention of Leukemia Relapse by Donor Activating<i>KIR2DS1</i> (2012)

Activating KIR genes from donors were associated with distinct outcomes of allogeneic HSCT for AML. Donor KIR2DS1 appeared to provide protection against relapse in an HLA-C-dependent manner, and donor KIR3DS1 was associated with reduced mortality. (Funded by the National Institutes of Health and others.).