gebhart/patrepeval huggingface dataset:
Identification of the facile gas-phase cleavage of the Asp-Pro and Asp-Xxx peptide bonds in matrix-assisted laser desorption time-of-flight mass spectrometry (1993)

Abundant ions corresponding to the gas-phase cleavage of the Asp-Pro and Asp-Xxx bonds of peptides in the process of matrix-assisted laser desorption were observed using a time-of-flight mass spectrometer equipped with both linear and reflector mass analyzers. Peptides containing the N-terminal sequence, Asp-Pro ... from an endoproteinase Asp-N digest yielded one peak in the molecular ion region in the linear mode and two equally abundant peaks in the reflector mode TOF mass spectra. The lower molecular masses in the reflector mode mass spectra could be eliminated by removing the Asp residue or derivatizing its side-chain carboxyl group. The observed mass differences did not correspond to any amino acid; however, by lowering the potential of the reflector to correct for the energy loss the mass difference was determined to be 115 Da, i.e., Asp. The extent and rate of this decomposition was compared with that obtained using a four-sector tandem mass spectrometer in the MS/MS mode of operation without and with a collision gas at collision cell potentials of 3.0 and 9.86 kV. These data suggest the Asp-Pro peptide bond is more labile than other peptide bonds in the gas phase. Abundant metastable decomposition of internal Asp-Pro bonds was also observed in larger peptides and proteins. Based on these latter data, a mechanism for this gas-phase cleavage is proposed.(ABSTRACT TRUNCATED AT 250 WORDS)
Silver Treatment of Carnation Flowers for Reducing Ethylene Damage and Extending Longevity1 (1977)

Abstract Direct coating of flowers of carnation ( Dianthus caryophyllus L. cv White Sim) with Ag ions by spraying or momentarily dipping flower heads with AgNO 3 (50-100 ppm) extended cut flower longevity and counteracted the enhancing effect of ethephon on senescence. Treating stems and leaves similarly had little or no effect. Stem base treatment with 1000 ppm was much less effective than treating the flower directly. Maximum efficiency of the AgNO 3 spray was obtained when a period of 2 hours elapsed between the AgNO 3 treatment and exposure to ethephon. In spite of the great extension in longevity, silver spray has limited practical use since it causes petal spotting.
Toward real-time and cooperative mobile visual sensing and sharing (2016)

Mobile social media enables people to record ongoing physical events they witness and share them instantaneously online. However, since these event pictures are often individually provided, they are typically fragmented and possess high redundancy. Though there have been studies about visual event summarization, they pay little attention to collaborative sensing, subevent detection, and event summary. In this paper, we present several building blocks for a cooperative visual sensing and sharing system. We create a virtual opportunistic community associated with an event, where members collaborate to cover different aspects of the event. More specifically, a crowd-powered approach is first used to localize the event. We then propose three subevent segmentation methods based on crowd-event interaction patterns. Based on the segmentation results, we summarize the event at two levels: multi-facet subevent summary and crowd-behavior-based highlights. Experiments over 21 online datasets and two real world datasets demonstrate the effectiveness of our approaches.
A molecular meccano kit † (2000)

A range of secondary dialkylammonium (R2NH2+) ions has been shown to thread through the cavities of appropriately-sized crown ether compounds to afford interwoven complexes. X-Ray crystallographic investigations to probe the solid-state properties of these supermolecules have revealed that many subtle factors—e.g., solvent of crystallisation, crown ether conformation and anion interactions—can influence the nature of the overall three-dimensional superstructures. Nonetheless, a family of building blocks—namely R2NH2+ ions and crown ethers—can be generated, which constitute a molecular meccano kit. By mixing and matching these modules in different ways, intricate interwoven supramolecular architectures can be constructed. From relatively simple beginnings—where one R2NH2+ ion is threaded through one monotopic crown ether (dibenzo[24]crown-8)—the designed evolution of the building blocks in the molecular meccano kit has led to more elaborate multiply encircled and/or multiply threaded superstructures. The effects of crown ether constitution, macroring size, and both crown ether as well as R2NH2+ ion substitution, upon the solid-state behaviour of these interwoven complexes have also been examined. A statistical analysis of the hydrogen bonding interactions observed in these systems has been carried out. It reveals that a reasonable correlation exists between N+–H⋯O bond angle and H⋯O bond length. The correlation between C–H⋯O bond angle and H⋯O distance is poor, suggesting that C–H⋯O hydrogen bonding interactions are of secondary importance in determining the co-conformations adopted by these supermolecules.
A Study on Transmitting GIS-based Traffic Information using DMB(Digital Multimedia Broadcasting) (2004)

The purpose of this study is to analyze DMB(digital multimedia broadcasting) technologies of transmitting GIS-based traffic information for developing DMB systems compared with FM DARC(FM data radio channel). R&D and standardizations for transmitting GIS-based traffic information have been rapidly changed, as radical developments in ITS(intelligent transportation systems), telemaics, and communication methods such as ubiquitous and convergences of broadcasting and communications. Each communication method employs different GIS format, protocol, and standardizations, i.e., GML(geography markup language) and TPEG(transport protocol experts group). This paper presents technical methods and trends of transmitting traffic information using broadcasting along with FM DARC, in general, and DMB, in particular.
Image Abstraction by Structure Adaptive Filtering (2008)

In this work we present a framework of automatic non-photorealistic image processing techniques that create simplified stylistic illustrations from color images, videos and 3D renderings. To smooth low-contrast regions while preserving edges, we present a new fast separated implementation of the bilateral filter. Our approach works by filtering in direction of the gradient and then filtering the intermediate result in perpendicular direction. When applied iteratively, our approach does not suffer from horizontal or vertical artifacts and creates smooth output at curved boundaries. To extract salient important edges we first apply a one-dimensional difference-of-Gaussians filter in direction of the gradient and then apply smoothing along a flow field which we derive from the smoothed structure tensor. Our method creates smooth coherent output for line and curve segments.
The history and development of the helium ion microscope (2011)

The helium ion microscope has recently emerged as a commercially available instrument. However, its roots go back more than 60 years to the development of the field ion microscope in Berlin, first reported in 1951. Over the intervening years, numerous researchers have pursued the development of a gas field ionization source with the goal of producing a suitable source for an ion microscope. This proved to be an elusive goal until early in this century when a number of discoveries led to a successful source, and shortly thereafter, an instrument fully able to exploit its advantages. Many individuals and many technical advances have come together to make this new class of microscope. The long history of this quest is reviewed along with the recent advances that led to the achievement of this milestone. A brief summary of the current status of the technology and its applications are given.
Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches (2019)

Overexpression of ABC transporters like P-glycoprotein (P-gp) has been correlated with resistances in cancer chemotherapy. Intensive efforts to identify P-gp inhibitors for use in combination therapy have not led to clinically approved inhibitors to date. Here, we describe computational approaches combined with structure-based design to improve the characteristics of a P-gp inhibitor previously identified by us. This hit compound represents a novel class of P-gp inhibitors that specifically targets and inhibits P-gp ATP hydrolysis while not being transported by the pump. We describe here a new program for virtual chemical synthesis and computational assessment, ChemGen, to produce hit compound variants with improved binding characteristics. The chemical syntheses of several variants, efficacy in reversing multidrug resistance in cell culture, and biochemical assessment of the inhibition mechanism are described. The usefulness of the computational predictions of binding characteristics of the inhibitor variants is discussed and compared to more traditional structure-based approaches.
Anti-Pentatrichomonas hominis activity of newly synthesized benzimidazole derivatives — in vitro studies (2009)

Abstract Pentatrichomonas hominis, a parasitic protozoan often detected in human diarrheic stools, is the cause of severe morbidity in newborns and children, particularly in tropical zones. The flagellate is resistant to many disinfectants and anti-protozoan drugs. Therefore in this study we have synthesized three novel 4,5,6,7-tetrabromobenzimidazole (TBBI) derivatives carrying a polyfluoroalkyl substituent in position 2 of the benzimidazole scaffold, namely 2-trifluoromethyl-TBBI (CF3-TBBI), 2-nonafluorobutyl-TBBI (C4F9-TBBI), and 2-nonadecafluorononyl-TBBI (C9F19-TBBI), that next we tested for their in vitro activity against P. hominis.Widely applied anti-protozoal drug, metronidazole as a reference was used. All the investigated agents were added to 24 h P. hominis cultures; each of them was administered at three different concentrations. Number of the moving trichomonads was determined and compared with the control cultures. Different anti-trichomonal activity occurred depending on a kind of compound and its concentration. C4F9-TBBI was the most effective TBBI derivative tested: the agent, at the highest concentration 24.2 μg/ml, after 72 h reduced the number of viable trichomonads to 44.3%; C9F19-TBBI, at the concentration 24 μg/ml reduced the number of the flagellates to 58.5%. Paradoxically, metronidazole after the same time given at the highest concentration increased trophozoite counts by 464.6% in comparison with the control cultures (100%).
Translation Products of Genome and Satellite RNAs of Tomato Black Ring Virus (1980)

SUMMARY In wheat germ extracts and reticulocyte lysates the genome RNA molecules of tomato black ring virus (TBRV), RNA-1 (mol. wt. 2.8 × 106) and RNA-2 (mol. wt. 1.6 × 106), were translated into products of maximum mol. wt. 2.2 × 105 and 1.6 × 105, respectively. These products represent about 80% and 100% of the coding capacity of the two RNA species. The 1.6 × 105 mol. wt. polypeptide reacted with antiserum to TBRV particles but the translation products of RNA-1 did not; this is additional evidence that RNA-2 contains the coat protein cistron. Satellite RNA molecules (RNA-3, mol. wt. 4.8 × 105) associated with strain S of TBRV, like those associated with strain G, were translated in wheat germ extracts into a polypeptide of mol. wt. 4.8 × 104; this did not react with TBRV antiserum. Protease digestion released peptides from the translation product of strain S RNA-3 which were different from those released from the translation product of strain G RNA-3, suggesting that the two kinds of satellite RNA molecules differ in base sequence.
Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, and Other Derivatives of Carbon‐20 Unsaturated Fatty Acids (1982)

In recent years, knowledge of the biochemistry of oxygenated metabolites of arachidonic acid has greatly increased. Their biological functions in acceleration and prevention of platelet aggregation and in inflammatory and immune reactions are becoming much clearer. The therapeutic value, particularly of PGI2 as well as selective inhibitors of synthesis, is also rapidly advancing. Despite much effort, the functional importance of prostaglandins and thromboxanes in the cNS in normal ongoing physiological processes is still quite uncertain. However, when parenchymal or vascular elements are damaged or invaded by extraneural cells, the synthesis of one or the other member of the eicosanoids is greatly increased and contributes significantly to pathophysiological reactions. Thus, prevention of synthesis is likely to have increasing importance in clinical neurology, particularly in cerebrovascular diseases.
Measurement of Smoke Particle Size under Low-Gravity Conditions (2008)

<div class="htmlview paragraph">Smoke detection experiments were conducted in the Microgravity Science Glovebox (MSG) on the International Space Station (ISS) during Expedition 15 in an experiment entitled Smoke Aerosol Measurement Experiment (SAME). The preliminary results from these experiments are presented. In order to simulate detection of a prefire overheated-material event, samples of five different materials were heated to temperatures below the ignition point. The smoke generation conditions were controlled to provide repeatable sample surface temperatures and air flow conditions. The smoke properties were measured using particulate aerosol diagnostics that measure different moments of the size distribution. These statistics were combined to determine the count mean diameter which can be used to describe the overall smoke distribution.</div>
Flavokawain B, a kava chalcone, induces apoptosis via up‐regulation of death‐receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth (2010)

Limited success has been achieved in extending the survival of patients with metastatic and hormone-refractory prostate cancer (HRPC). There is a strong need for novel agents in the treatment and prevention of HRPC. We have shown that flavokawain B (FKB), a kava chalcone, is about 4- to 12-fold more effective in reducing the cell viabilities of androgen receptor (AR)-negative, HRPC cell lines DU145 and PC-3 than AR-positive, hormone-sensitive prostate cancer cell lines LAPC4 and LNCaP, with minimal effect on normal prostatic epithelial and stromal cells. FKB induces apoptosis with an associated increased expression of proapoptotic proteins: death receptor-5, Bim and Puma and a decreased expression of inhibitors of apoptosis protein: XIAP and survivin. Among them, Bim expression was significantly induced by FKB as early as 4 hr of the treatment. Knockdown of Bim expression by short-hairpin RNAs attenuates the inhibitory effect on anchorage-dependent and -independent growth and caspase cleavages induced by FKB. These findings suggest that the effect of FKB, at least in part, requires Bim expression. In addition, FKB synergizes with TRAIL for markedly enhanced induction of apoptosis. Furthermore, FKB treatment of mice bearing DU145 xenograft tumors results in tumor growth inhibition and increases Bim expression in tumor tissues. Together, these results suggest robust mechanisms for FKB induction of apoptosis preferentially for HRPC and the potential usefulness of FKB for prevention and treatment of HRPC in an adjuvant setting.
UV cured transparent films including non‐aqueous conductive microgels (2002)

Abstract UV cured transparent films containing non‐aqueous conductive microgels coated with poly(aniline)/dodecyl benzenesulfonic acid(DBSA) were obtained. The conductive microgels were prepared by interface polymerization of aniline/DBSA in the presence of non‐aqueous polymeric microgels. The electrical conductivity and the particle size of the prepared conductive microgel were 0.5 S/cm and 58 nm, respectively. The prepared conductive microgels were easily blended with a UV curable coating formulation, and then were cured to make highly optically transparent films. For the UV cured film containing about 35 wt% of the conductive microgels, a surface resistance in the range of 10 7 to 10 8 Ω/square was obtained. In a polar cosolvent, such as NMP and m ‐cresol, the critical volume was shifted to the lower range, with a value of 10 wt%. The UV cured films containing the conductive microgels exhibited good electrical stability against the thermal aging and humidity. Copyright © 2002 John Wiley & Sons, Ltd.
Controlling widgets with one power-up button (2013)

The Power-up Button is a physical button that combines pressure and proximity sensing to enable gestural interaction with one thumb. Combined with a gesture recognizer that takes the hand's anatomy into account, the Power-up Button can recognize six different mid-air gestures performed on the side of a mobile device. This gives it, for instance, enough expressive power to provide full one-handed control of interface widgets displayed on screen. This technology can complement touch input, and can be particularly useful when interacting eyes-free. It also opens up a larger design space for widget organization on screen: the button enables a more compact layout of interface components than what touch input alone would allow. This can be useful when, e.g., filling the numerous fields of a long Web form, or for very small devices.
Combined M.D./Ph.D. and Ph.D. Training Program in Breast Cancer Prevention (2000)

Abstract : The goal of this training program is to dramatically extend our existing, highly successful Interdisciplinary Doctoral Training Program in Tumor Biology with a new track which integrates genetics, molecular epidemiology, and prevention of breast cancer. This new track offers both MD/PhD and PhD training opportunities, and integrates new faculty from the Lombardi Cancer Center Programs in Cancer Prevention and Control, and Cancer Genetics. The program is enriched by new courses, as well as practical research experience. This new programmatic initiative makes use of the existing organizational structure of the Interdisciplinary Doctoral Training Program in Tumor Biology and incorporates a multi-disciplinary faculty who are devoted to research and education in breast cancer. We have enrolled our first incoming class of two PhD students and have recruited a second year incoming class of one MD/PhD student and two PhD students. Additionally, new course components have been incorporated into the Breast Cancer Prevention track that focus on cancer genetics, cancer prevention, and epidemiology and cancer risk.
Asymmetric bihomologous crosslinkers for bicomponent gels—The way to strongly increased elastic moduli (2009)

Abstract 2‐Hydroxyethylmethacrylate (HEMA) and acrylamide (AA) have been copolymerized via free radical mechanism, in the presence of 5 mol % of four different crosslinker systems, the symmetric ethylenglycoldimethacrylate (EGDMA), bisacrylamide (BIS), a mixture of EGDMA and BIS, and the asymmetric acrylamideethylenmethacrylate (METAA). The polymerizations have been monitored with a rheometer, exhibiting the gel obtained with the asymmetric METAA, an elastic modulus that is dramatically increased compared with those of the gels prepared with the other three crosslinker systems. A kinetic analysis using the terminal model has been used to build probabilistic surfaces that give information about how the crosslinker is incorporated into the network. This analysis shows a high dissimilarity between the reactions using the asymmetric and the mixture of symmetric crosslinkers, what has been correlated to the difference in modulus. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Brain proteins in plants: an Arabidopsis homolog to neurotransmitter pathway activators is part of a DNA binding complex. (1992)

The G box is a well-characterized cis-acting DNA regulatory element found in the promoters of several seemingly unrelated plant genes, including the alcohol dehydrogenase (Adh) gene of Arabidopsis thaliana. Using a monoclonal antibody screening approach coupled with electrophoretic mobility shift assays, we have isolated a cDNA clone encoding a protein that is part of the in vitro protein/G box complex. The derived amino acid sequence is homologous to a class of proteins in mammalian brains described as protein kinase C inhibitors and as activators of tyrosine and tryptophan hydroxylases, the rate-limiting enzymes in the pathways leading to the catecholamines and serotonin. The fact that a homologous member of this regulatory protein family is found in plants and is associated with binding to transcriptional regulatory elements suggests a much wider role for these proteins.
State-of-art of energy system for new energy vehicles (2008)

The energy system consists of batteries and/or ultra-capacitors and BMS. Different type of EVs needs different energy system. The energy system is the key to the future of new energy vehicles including pure electric vehicle, hybrid vehicles and plug-in hybrid and fuel cell vehicles etc.. The paper will present the state-of-art of energy system for new energy vehicles around the world especially in China.
Poly-Arginine and Arginine-Rich Peptides are Neuroprotective in Stroke Models (2015)

Using cortical neuronal cultures and glutamic acid excitotoxicity and oxygen-glucose deprivation (OGD) stroke models, we demonstrated that poly-arginine and arginine-rich cell-penetrating peptides (CPPs), are highly neuroprotective, with efficacy increasing with increasing arginine content, have the capacity to reduce glutamic acid-induced neuronal calcium influx and require heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. Furthermore, neuroprotection could be induced with immediate peptide treatment or treatment up to 2 to 4 hours before glutamic acid excitotoxicity or OGD, and with poly-arginine-9 (R9) when administered intravenously after stroke onset in a rat model. In contrast, the JNKI-1 peptide when fused to the (non-arginine) kFGF CPP, which does not rely on endocytosis for uptake, was not neuroprotective in the glutamic acid model; the kFGF peptide was also ineffective. Similarly, positively charged poly-lysine-10 (K10) and R9 fused to the negatively charged poly-glutamic acid-9 (E9) peptide (R9/E9) displayed minimal neuroprotection after excitotoxicity. These results indicate that peptide positive charge and arginine residues are critical for neuroprotection, and have led us to hypothesize that peptide-induced endocytic internalization of ion channels is a potential mechanism of action. The findings also question the mode of action of different neuroprotective peptides fused to arginine-rich CPPs.
A High-Rate Energy-Resolving Photon-Counting ASIC for Spectral Computed Tomography (2011)

We describe a high-rate energy-resolving photon-counting ASIC aimed for spectral computed tomography. The chip has 160 channels and 8 energy bins per channel. It demonstrates a noise level of ENC =214 electrons at 5 pF input load at a power consumption of <; 5 mW/channel. Maximum count rate is 17 Mcps at a peak time of 40 ns, made possible through a new filter reset scheme, and maximum read-out frame rate is 37 kframe/s.