gebhart/patrepeval huggingface dataset:
BENEFICIAL EFFCTS OF LASER THERAPY IN THE EARLY STAGES OF RHEUMATOID ARTHRITIS ONSET (1999)

The purpose of this study was to determine the effects of laser therapy in pain reduction and/or recovery of patients at the onset of Rheumatoid Arthritis (RA), comparatively with the traditional nonsteroidal anti-inflammatory drugs (NSAIDs). Fifty-nine patients with RA of 6-12 months duration were included in the study. The patients were divided into 3 groups: Group 1 (21 patients) received laser therapy; Group 2 (18 patients) was submitted to placebo laser therapy and NSAIDs medication; Group 3 (20 patients) was treated only with NSAIDs. Physical therapy was instituted in all three groups. GaAIAs diode laser of 830 nm wavelength and 200 mW maximum output power was used. Group 1 received laser therapy once each day, eight days per month, for a total of 32 treatments during a four-month period. The parameters used were 2-4 J/cm2 energy density, and a frequency of 5 Hz or 10 Hz depending on the number and severity of pain in the affected joints. Placebo laser treatment was given to group 2. The functional activity score, the acute phase reactants (ESR and C - reactive protein), T - lymphocytes and NK (natural killer) - cells were estimated. Synovial biopsies and Magnetic Resonance Imaging (MRI) of the synovial membrane were performed as well. The analysis of the clinical and biological parameters at the end of treatment showed a statistically significant decrease of duration of morning stiffness, of pain at rest and during movements, and improved acute phase reactants. The overall efficacy rate in these studies was 86% in the fttst group, 50% in laser placebo group and 40% in the NSAIDs-treated third group. After four months of treatment, our investigations showed that 830 nm infrared laser therapy promoted the restoration of function, relieved pain and limited the complications of RA.
The clinical course of neuromyelitis optica (Devic’s syndrome) (1999)

Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS. Patients with relapsing optic neuritis and myelitis may have neuromyelitis optica rather than MS. Patients with a relapsing course of neuromyelitis optica have a poor prognosis and frequently develop respiratory failure during attacks of cervical myelitis.
New Catalytic Materials for the Direct Epoxidation of Propylene by Molecular Oxygen (2010)

Abstract The direct vapor‐phase production of propylene oxide (PO) from propylene and molecular oxygen without the use of a co‐reactant remains a challenging problem in industrial catalysis, in spite of several decades of research. Herein, the discovery of a new class of silica‐supported multimetallic RuO 2 –CuO x –NaCl catalysts for the direct synthesis of PO from propylene and molecular oxygen is reported. This trimetallic catalyst exhibits durability and delivers PO selectivities of 40–50 % at propylene conversions of 10–20 % within 240‐270 °C and at atmospheric pressure. The best performing catalysts are characterized by powder X‐ray diffraction (PXRD) and transmission electron microscopy (TEM) and are determined to be composed of nanocrystalline domains of the three phases of RuO 2 , CuO x , and NaCl.
A spatio-temporal low-rank total variation approach for denoising arterial spin labeling MRI data (2015)

Arterial spin labeling MRI (ASL-MRI) can provide quantitative signals correlated to the cerebral blood flow and neural activity. However, the low signal-to-noise ratio in ASL requires repeated acquisitions to improve the signal reliability, leading to prolonged scanning time. At fewer repetitions, noise and corruptions arise due to motion and physiological artifacts, introducing errors into the cerebral blood flow estimation. We propose to recover the ASL-MRI data from the noisy and corrupted observations at shorter scanning time with a spatio-temporal low-rank total variation method. The low-rank approximation uses the similarity of the repetitive scans, and the total variation regularization considers the local spatial consistency. We compare with the state-of-art robust M-estimator for ASL cerebral blood flow map estimation. Validation on simulated and real data demonstrate the robustness of the proposed method at fewer scanning repetitions and with random corruption.
Molecular karyotyping of cell-free DNA from blastocoele fluid as a basis for noninvasive preimplantation genetic screening of aneuploidy (2015)

The discovery of DNA fragments in the blastocoele fluid is promising for the development of new noninvasive methods for the preimplantation genetic diagnosis of chromosomal diseases. However, to date there are no data confirming the concordance between the molecular karyotype of cell-free DNA from blastocoele fluid and the blastocyst cells per se. This paper reports on this concordance according to the results of molecular-cytogenetic analysis of the chromosomal set with the use of comparative genomic hybridization.
Thermodynamic Analysis of the Structural Stability of the Shiga Toxin B-Subunit (2003)

The conformational stability of Shiga toxin B-subunit (STxB), a pentameric protein from Shigella dysenteriae has been characterized by high sensitivity differential scanning calorimetry and circular dichroism spectroscopy under different solvent conditions. It is shown that the thermal folding/unfolding of STxB is a reversible process involving a highly cooperative transition between folded pentamer and unfolded monomers. The conformational stability of STxB is pH dependent and because of its pentameric nature is also concentration dependent. STxB is maximally stable in the pH range from 5 to 9 (Delta G upon unfolding is close to 13 kcal per mol of monomer at 25 degrees C), and its stability decreases both at lower and at higher pH values. The pH dependence of the Gibbs energy of stabilization between pH 2.5 and 5 is consistent with the change in the ionizable state of an average of four groups per monomer upon unfolding. Structural thermodynamic calculations show that the stabilization of the STxB pentamer is primarily due to the interactions established between monomers rather than intramonomer interactions. The folding of an isolated monomer into the conformation existing in the pentamer is unfavorable and expected to be characterized by a free-energy change upon folding in the order of 2.5 kcal mol(-1) at 25 degrees C. On the average, intersubunit interaction induced upon oligomerization of folded monomers should contribute close to -13.4 kcal per mol of monomer to bring the overall Gibbs energy to the experimentally determined value at this temperature.
Treatment of Capsular Contracture Using Complete Implant Coverage by Acellular Dermal Matrix (2013)

Capsular contracture may be treated successfully using complete acellular dermal matrix coverage. This technique may be a useful addition to therapies currently used to treat recalcitrant capsular contracture (early recurrence or refractory to standard therapy).
Isolation and characterization of Chinese hamster ovary cell mutants defective in assembly of peroxisomes. (1990)

We made use of autoradiographic screening to isolate two Chinese hamster ovary (CHO) cell mutants deficient in peroxisomal dihydroxyacetonephosphate acyltransferase, a key enzyme for the biosynthesis of ether glycerolipids such as plasmalogens. Morphological analysis revealed no evidence of peroxisome in these mutants. Catalase was as active as in the normal cells but was not sedimentable. Pulse-chase radiolabeling experiments and cell-free translation of RNA demonstrated that acyl-CoA oxidase, the first enzyme of the peroxisomal beta-oxidation system, was synthesized as the 75-kD form but was not converted to 53- and 22-kD mature components that were present in the wild-type CHO cells; rather, degradation was apparent. Peroxisomal thiolase was synthesized as in normal cells but remained as a larger, 44-kD precursor, whereas maturation to the 41-kD enzyme was detected in the wild-type cells. The peroxisomal 70-kD integral membrane protein was also equally synthesized, as in the wild-type cells, and was not degraded. These results suggest that assembly of the peroxisomes is defective in the mutants, whereas the synthesis of peroxisomal proteins appears to be normal. Cell-fusion studies revealed that the two mutants are recessive to the wild-type CHO cells and belong to different complementation groups. Thus, these mutants presumably contain different lesions in gene(s) encoding factor(s) required for peroxisome assembly.
The primary structure of rat ribosomal protein L32 (1988)

Journal Article The primary structure of rat ribosomal protein L32 Get access Andrzej Rajchel, Andrzej Rajchel Department of Biochemistry and Molecular Biology, University of ChicagoChicago, IL 60637, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuen-Ling Chan, Yuen-Ling Chan Department of Biochemistry and Molecular Biology, University of ChicagoChicago, IL 60637, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Ira G. Wool Ira G. Wool * Department of Biochemistry and Molecular Biology, University of ChicagoChicago, IL 60637, USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 5, 11 March 1988, Page 2347, https://doi.org/10.1093/nar/16.5.2347 Published: 11 March 1988 Article history Received: 14 January 1988 Published: 11 March 1988
Current status and recommendations toward a virus standard for ballast water (2019)

Ballast water contains and transfers a variety of biological and non-biological materials between biomes. This study aimed to summarize published literature on the viruses found in ballast water, to evaluate ultrafiltration and plaque assay as methods for concentrating and enumerating viruses, and to assess the efficacy of UV irradiation in the inactivation of infectious viruses in ballast water. Previous studies reported high virus concentrations in ballast tanks, ranging from 109 to 1014 viral particles/L. The ultrafiltration and plaque assay were efficient in concentrating and enumerating four types of phages: MS2, PhiX174, P22, and PP7. The UV dose (radiant fluence) necessary to achieve a 4-log reduction of the four phages ranged from 6.1 to 77.7 mJ/cm2 with MS2 being the most UV-resistant phage. The results illustrated the applicability of ultrafiltration and plaque assay techniques for quantifying viruses in ballast waters and pointed to the need for additional test microorganisms for assessing ballast water quality.
Evaluation of dressing regimens for prevention of infection with peripheral intravenous catheters. Gauze, a transparent polyurethane dressing, and an iodophor-transparent dressing (1987)

Four dressing regimens for peripheral venous catheters were studied in a prospective randomized clinical trial with 2088 Teflon catheters: (1) sterile gauze, replaced every other day, and three dressings left on for the lifetime of the catheter; (2) gauze; (3) a transparent polyurethane dressing; and (4) an iodophor-transparent dressing. The four dressings provided comparable coverage, except moisture accumulated more frequently under the transparent dressings 26% to 28% vs 20% to 21% Cutaneous colonization under the dressing was low level and comparable with all four dressings (range, 100.58 to 100.70 colony-forming units). The rate of local catheter-related infection ≥15 colony-forming units) was also low and did not differ significantly (range, 4.6% to 5.9%); no catheter caused bacteremia. Stepwise logistic multivariate analysis showed cutaneous colonization of the insertion site (relative risk [RR] of infection, 3.86), contamination of the catheter hub (RR, 3.78), moisture under the dressing (RR, 2.48), and prolonged catheterization (RR, 1.75) to be significant risk factors for catheter-related infection. These data indicate that it is not cost-effective to redress peripheral venous catheters at periodic intervals; for most patients, either sterile gauze or a transparent dressing can be used and left on until the catheter is removed. (<i>JAMA</i>1987;258:2396-2403)
Pharmacodynamic Markers of Perifosine Efficacy (2007)

Because of a strong correlation between proportional modulation of PI3K pathway biomarkers and quantified perifosine efficacy, it is likely that early measurement of such pharmacodynamic biomarkers with reverse phase protein array will optimize selection of responding patients and guide perifosine dosing. Furthermore, PI3K pathway activation status may allow baseline selection of patients most likely to respond to perifosine alone or in combination with other therapies.
Some ECM aspects for phased array systems (2002)

This paper provides a brief overview of electronic counter measure (ECM) aspects related to phased array systems and highlights techniques and concepts from available literature. It is not intended to have a comprehensive coverage of the subject. The aim is to have a discussion which may bring out certain new aspects in this important and sensitive area.
Peroxiredoxin 1 Controls Prostate Cancer Growth through Toll-Like Receptor 4–Dependent Regulation of Tumor Vasculature (2011)

In recent years a number of studies have implicated chronic inflammation in prostate carcinogenesis. However, mitigating factors of inflammation in the prostate are virtually unknown. Toll-like receptor 4 (TLR4) activity is associated with inflammation and is correlated with progression risk in prostate cancer (CaP). TLR4 ligands include bacterial cell wall proteins, danger signaling proteins, and intracellular proteins such as heat shock proteins and peroxiredoxin 1 (Prx1). Here we show that Prx1 is overexpressed in human CaP specimens and that it regulates prostate tumor growth through TLR4-dependent regulation of prostate tumor vasculature. Inhibiting Prx1 expression in prostate tumor cells reduced tumor vascular formation and function. Furthermore, Prx1 inhibition reduced levels of angiogenic proteins such as VEGF within the tumor microenvironment. Lastly, Prx1-stimulated endothelial cell proliferation, migration, and differentiation in a TLR4- and VEGF-dependent manner. Taken together, these results implicate Prx1 as a tumor-derived inducer of inflammation, providing a mechanistic link between inflammation and TLR4 in prostate carcinogenesis. Our findings implicate Prx1 as a novel therapeutic target for CaP.
Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin (2016)

Bacimethrin (4-amino-5-hydroxymethyl-2-methoxypyrimidine), a natural product isolated from some bacteria, has been implicated as an inhibitor of bacterial and yeast growth, as well as in inhibition of thiamin biosynthesis. Given that thiamin biosynthetic enzymes could convert bacimethrin to 2'-methoxythiamin diphosphate (MeOThDP), it is important to evaluate the effect of this coenzyme analogue on thiamin diphosphate (ThDP)-dependent enzymes. The potential functions of MeOThDP were explored on five ThDP-dependent enzymes: the human and Escherichia coli pyruvate dehydrogenase complexes (PDHc-h and PDHc-ec, respectively), the E. coli 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), and the human and E. coli 2-oxoglutarate dehydrogenase complexes (OGDHc-h and OGDHc-ec, respectively). Using several mechanistic tools (fluorescence, circular dichroism, kinetics, and mass spectrometry), it was demonstrated that MeOThDP binds in the active centers of ThDP-dependent enzymes, however, with a binding mode different from that of ThDP. While modest activities resulted from addition of MeOThDP to E. coli PDHc (6-11%) and DXPS (9-14%), suggesting that MeOThDP-derived covalent intermediates are converted to the corresponding products (albeit with rates slower than that with ThDP), remarkably strong activity (up to 75%) resulted upon addition of the coenzyme analogue to PDHc-h. With PDHc-ec and PDHc-h, the coenzyme analogue could support all reactions, including communication between components in the complex. No functional substitution of MeOThDP for ThDP was in evidence with either OGDH-h or OGDH-ec, shown to be due to tight binding of ThDP.
Sector beam synthesis for cellular systems using phased antenna arrays (2003)

Cell sectorization is used extensively to increase the capacity of cellular systems; however, inter-sector interference caused by non-ideal sector antennas hinders full realization of sectorization benefits. We propose a new technique for sector beam synthesis, using phased antenna arrays, to minimize inter-sector interference, or equivalently, to maximize the beam efficiency. A peak-to-peak ripple constraint on the power density inside the sector leads to a non-convex optimization task; a reparametrization results in an easily solved convex fractional linear program. The proposed procedure accommodates non-isotropic antenna elements, arbitrary element spacing, and arbitrary sector boundaries, but is limited to uniformly spaced linear (or planar) arrays. Finally, the proposed method is used to predict antenna array size requirements for a DS-CDMA cellular system.
Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE): A Case–Control Study (2020)

The association of sodium intake and stroke is J-shaped, with high sodium intake a stronger risk factor for ICH than ischemic stroke. Our data suggest that moderate sodium intake-rather than low sodium intake-combined with high potassium intake may be associated with the lowest risk of stroke and expected to be a more feasible combined dietary target.
Hierarchical Representation of Three-Dimensional Objects Using Verbal Models (1981)

We present a formalism for the computer representation of three-dimensional shapes, that has as its goal to facilitate man-machine communication using verbal, graphic, and visual means. With this method, pieces may be assembled hierarchically using any of severalways of specifying attachment. The primitives of the representation are generalized cylinders, and the creating of assemblies may make use of the axes inherent in the primitives. Generic models may be described that may leave some parameters or dimensions unspecified, so that when a specific instance of the model is described, those parameters may either be explicitly specified or take on default values. The axes of local coordinate frames may be given symbolic names. A set of computer programs translates descriptions of objects into polyhedral models and line drawings.
Synthesis of Shell Cross-Linked Micelles with Tunable Hydrophilic/Hydrophobic Cores (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis of Shell Cross-Linked Micelles with Tunable Hydrophilic/Hydrophobic CoresV. Bütün, N. C. Billingham, and S. P. ArmesView Author Information School of Chemistry Physics and Environmental Science University of Sussex Falmer, Brighton, BN1 9QJ, UK Cite this: J. Am. Chem. Soc. 1998, 120, 46, 12135–12136Publication Date (Web):November 6, 1998Publication History Received3 June 1998Published online6 November 1998Published inissue 1 November 1998https://pubs.acs.org/doi/10.1021/ja981932uhttps://doi.org/10.1021/ja981932urapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views2192Altmetric-Citations193LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymers,Micelles,Nuclear magnetic resonance spectroscopy,Nucleic acid structure,Solution chemistry Get e-Alerts
A Hall effect transducer for measuring length changes in mammalian diaphragm (1983)

When a conductor through which a current is flowing is brought into a magnetic field, the isopotential lines are distorted (E. H. Hall, 1879). When a constant current is made to flow through a Hall generator, the measured voltage perpendicular to the current flow can be made to vary by altering the distance between a permanent magnet and a Hall generator. A length transducer useful for measuring length changes in the diaphragm of a dog is made by connecting a commercially available Hall generator to a Plexiglas plate (5 X 10 X 3 mm, 0.5 g), and suturing the plate to the surface of the muscle. A permanent magnet (20 X 10 X 4 mm, 1.5 g) is attached to the diaphragm at a distance of 2 or 3 cm along the expected direction of length change. Fine wires from the terminals of the Hall generator are connected to an external constant-current source and to solid-state circuitry which provides amplification, linearization, and temperature compensation of the output signal. Model experiments indicate that the length measurements may be accurate within 5% if the distance between the magnet and Hall generator is greater than 5 mm. With this type of transducer measurements of segmental length changes in the diaphragm of an anesthetized dog have been successfully recorded.
Future prospects for tissue engineered lung transplantation (2014)

The shortage of donor lungs for transplantation causes a significant number of patient deaths. The availability of laboratory engineered, functional organs would be a major advance in meeting the demand for organs for transplantation. The accumulation of information on biological scaffolds and an increased understanding of stem/progenitor cell behavior has led to the idea of generating transplantable organs by decellularizing an organ and recellularizing using appropriate cells. Recellularized solid organs can perform organ-specific functions for short periods of time, which indicates the potential for the clinical use of engineered solid organs in the future. The present review provides an overview of progress and recent knowledge about decellularization and recellularization-based approaches for generating tissue engineered lungs. Methods to improve decellularization, maturation of recellularized lung, candidate species for transplantation and future prospects of lung bioengineering are also discussed.
Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia (1985)

• A randomized double-blind trial of topical minoxidil therapy was carried out on 56 patients with hereditary male pattern baldness. The subjects selected were required to have a discernible balding patch, a minimum of 2.5 cm in diameter on the vertex of the head where the hairs could be counted and photographed. Minoxidil, 1.0 mL, was applied twice a day to the scalp beginning at the balding vertex and spreading centrifugally around the scalp. Cosmetically acceptable hair growth was achieved in 18 patients (32%). The most notable indicators for regrowth of hair were the number of indeterminate hairs initially present, the duration of baldness, and the size of the balding area. No serious systemic or cutaneous side effects were noted. (<i>Arch Dermatol</i>1985;121:197-202)