gebhart/patrepeval huggingface dataset:
Transforming Growth Factor Beta 1 and Hyaluronan Oligomers Synergistically Enhance Elastin Matrix Regeneration by Vascular Smooth Muscle Cells (2008)

Elastin is a vital structural and regulatory matrix protein that plays an important role in conferring elasticity to blood vessel wall. Previous tissue engineering approaches to regenerate elastin in situ or within tissue engineering constructs are curtailed by innate poor elastin synthesis potential by adult vascular smooth muscle cells (SMCs). Currently, we seek to develop cellular cues to enhance tropoelastin synthesis and improve elastin matrix yield, stability, and ultrastructure. Our earlier studies attest to the elastogenic utility of hyaluronan (HA)-based cellular cues, though their effects are fragment size dependent and dose dependent, with HA oligomers deemed most elastogenic. We presently show transforming growth factor beta 1 (TGF-beta1) and HA oligomers, when provided concurrently, to synergistically and dramatically improve elastin matrix regeneration by adult vascular SMCs. Together, these cues suppress SMC proliferation, enhance synthesis of tropoelastin (8-fold) and matrix elastin protein (5.5-fold), and also improve matrix elastin yield (45% of total elastin vs. 10% for nonadditive controls), possibly by more efficient recruitment of tropoelastin for crosslinking. The density of desmosine crosslinks within the elastin matrix was itself attenuated, although the cues together modestly increased production and activity of the elastin crosslinking enzyme, lysyl oxidase. TGF-beta1 and HA oligomers together induced much greater assembly of mature elastin fibers than they did separately, and did not induce matrix calcification. The present outcomes might be great utility to therapeutic regeneration of elastin matrix networks in situ within elastin-compromised vessels, and within tissue-engineered vascular graft replacements.
Effect of Fluorocarbon and Hydrocarbon Chain Lengths in Hybrid Surfactants for Supercritical CO<sub>2</sub> (2015)

Hybrid surfactants containing both fluorocarbon (FC) and hydrocarbon (HC) chains have recently been shown to solubilize water and form elongated reversed micelles in supercritical CO2. To clarify the most effective FC and HC chain lengths, the aggregation behavior and interfacial properties of hybrid surfactants FCm-HCn (FC length m/HC length n = 4/2, 4/4, 6/2, 6/4, 6/5, 6/6, and 6/8) were examined in W/CO2 mixtures as functions of pressure, temperature, and water-to-surfactant molar ratio (W0). The solubilizing power of hybrid surfactants for W/CO2 microemulsions was strongly affected by not only the FC length but also by that of the HC. Although the surfactants having short FC and/or HC tails (namely, m/n = 4/2, 4/4, and 6/2) did not dissolve in supercritical CO2 (even at ∼17 mM, ≤400 bar, temperature ≤ 75 °C, and W0 = 0-40), the other hybrid surfactants were able to yield transparent single-phase W/CO2 mixtures identified as microemulsions. The solubilizing power of FC6-HCm surfactants reached a maximum (W0 ∼ 80 at 45 °C and 350 bar) with a hydrocarbon length, m, of 4. The W0 value of 80 is the highest for a HC-FC hybrid surfactant, matching the highest value reported for a FC surfactant which contained more FC groups. High-pressure small-angle neutron scattering measurements from FCm-HCn/D2O/CO2 microemulsions were consistent with growth of the microemulsion droplets with increasing W0. In addition, not only spherical reversed micelles but also nonspherical assemblies (rodlike or ellipsoidal) were found for the systems with FC6-HCn (n = 4-6). At fixed surfactant concentration and W0 (17 mM and W0 = 20), the longest reversed micelles were obtained for FC6-HC6 where a mean aspect ratio of 6.3 was calculated for the aqueous cores.
The study of multi-level authentication-based single sign-on system (2009)

Single Sign on (SSO) is a method for accessing resources within multiple systems. However, some security vulnerabilities exist in current SSO systems, and user's experience is not convenient. This paper proposes an extension of SSO, named multi-level authentication-based SSO (MLA-SSO). In MLA-SSO, SPs are divided into several levels based on security intensity. This allows the model to benefit from key advantages in security of the scheme. In specific procedures, MLA-SSO adds security strategy consultations. So MLA-SSO can help users to realize unified login and logout in their ways. At last, the design and implementation of a prototype of MLA-SSO, i.e. SHARE, is introduced and discussed.
Dissociation of the actin.subfragment 1 complex by adenyl-5'-yl imidodiphosphate, ADP, and PPi. (1980)

The ability of adenyl-5'-yl imidodiphosphate (AMP-PNP), ADP, and PPi to dissociate the actin.myosin subfragment 1 (S-1) complex was studied using an analytical ultracentrifuge with UV optics, which enabled the direct determination of the dissociated S-1. At mu = 0.22 M, pH 7.0, 22 degrees C, with saturating nucleotide present, ADP weakens the binding of S-1 to actin about 40-fold (K congruent to 10(5) M-1), while both AMP-PNP and PPi weakens the binding about 400-fold (K congruent to 10(4) M-1). This 10-fold stronger dissociating effect of AMP-PNP and PPi compared to ADP correlates with our data showing that the binding of AMP-PNP and PPi to S-1 is about 10-fold stronger than the binding of ADP. In contrast, the binding constants of ADP, AMP-PNP, and PPi to acto.S-1 are nearly identical (K congruent to 5 x 10(3) M-1). At 4 degrees C, AMP-PNP has only a 3-fold stronger dissociating effect than ADP and, similarly, our data suggest that the binding of AMP-PNP and ADP to S-1 is quite similar at 4 degrees C. AMP-PNP and PPi are, therefore, somewhat better dissociating agents than ADP, but the difference among these three ligands is quite small. These data also show that actin and nucleotide bind to separate but interacting sites on S-1 and that the S-1 molecules bind independently along the F-actin filament with a binding constant of about 1 x 10(7) M-1 at 22 degrees C and physiological ionic strength.
Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis (2014)

Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age. We previously reported that factors produced by human embryonic stem cells (hESCs) support a robust regenerative capacity for adult and old mouse muscle stem/progenitor cells. Here we extend these findings to human muscle progenitors and investigate underlying molecular mechanisms. Our results demonstrate that hESC-conditioned medium enhanced the proliferation of mouse and human muscle progenitors. Furthermore, hESC-produced factors activated MAPK and Notch signaling in human myogenic progenitors, and Delta/Notch-1 activation was dependent on MAPK/pERK. The Wnt, TGF-β and BMP/pSmad1,5,8 pathways were unresponsive to hESC-produced factors, but BMP signaling was dependent on intact MAPK/pERK. c-Myc, p57, and p18 were key effectors of the enhanced myogenesis promoted by the hECS factors. To define some of the active ingredients of the hESC-secretome which may have therapeutic potential, a comparative proteomic antibody array analysis was performed and identified several putative proteins, including FGF2, 6 and 19 which as ligands for MAPK signaling, were investigated in more detail. These studies emphasize that a "youthful" signaling of multiple signaling pathways is responsible for the pro-regenerative activity of the hESC factors.
Comparison of degradation mechanisms of blue‐violet laser diodes grown on SiC and GaN substrates (2006)

Abstract In this work we present degradation studies of GaN based blue‐violet laser diodes grown on different substrates. By replacing the SiC substrate by GaN substrate, we change from hetero to homo epitaxy, while the threading dislocation density (TDD) is reduced by 3 orders of magnitude. A detailed analysis of small signal I – V curves shows an increase of non radiative (NR) recombination centers during aging for laser diodes on SiC substrate. This was not observed for lasers on GaN substrate due to the reduced TDD and therefore reduced number of diffusion channels for Mg‐atoms, acting as NR recombination centers in the active region. With an improved epitaxial structure on GaN substrate, we increased the lifetime of our lasers by a factor of 10. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Prognostic Role of Glasgow Prognostic Score in Patients With Hepatocellular Carcinoma (2015)

Conflicting results about the prognostic value of Glasgow Prognostic Score (GPS) in hepatocellular carcinoma (HCC) patients have been reported. We searched the available articles and performed the meta-analysis to clarify the predictive value of GPS in HCC patients' outcome.A systematic literature search was conducted using PubMed (Medline), Embase, Cochrane Library, Web of Science, ChinaInfo, and Chinese National Knowledge Infrastructure for all years up to September 2015. Studies analyzing the relationship of GPS and survival outcome were identified. Hazard ratio (HR) with 95% confidence interval (CI) was calculated to assess the risk.A total of 10 studies were finally enrolled in the meta-analysis. The pooled estimates demonstrated a significant relationship between elevated GPS and inferior overall survival in patients with HCC (HR = 2.156, 95% CI: 1.696-2.740, P < 0.001). Patients with increased GPS had a tendency toward shorter progression-free survival (HR = 1.755, 95% CI: 0.943-3.265, P = 0.076). And elevated GPS was found to be significantly associated with advanced Child-Pugh class (odds ratio = 25.979, 95% CI: 6.159-109.573, P < 0.001). The publication bias analysis revealed that there was publication bias in the meta-analysis.Glasgow Prognostic Score may be an independent prognostic factor in patients with HCC. More well-designed studies with adequate follow-up duration are warranted.
Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle (1977)

Due to the massive data sets available for drug candidates, modern drug discovery has advanced to the big data era. Central to this shift is the development of artificial intelligence approaches to implementing innovative modeling based on the dynamic, ...Read More
Reducing CBC Clotting Rates in the Neonatal Patient Care Areas (2016)

Performing a complete blood count (CBC) is a common test performed in neonatal intensive care. Samples reported as "clotted" are not able to be analyzed and require redraw. A perceived "high" clotting rate elicits frustration among team members and has negative effects on patient flow and patient satisfaction. Process mapping and a root cause analysis determined that an educational intervention was required to optimize blood collection skills of front-line nurses. Through four rapid PDSA cycles over a three year period, the neonatal patient care areas were able to decrease their CBC clotting rates from 30% (monthly rate when the problem was identified) to 16% (yearly average at the end of the project). The CBC clotting rates continue to decease over time due to the integration of a multi-faceted educational plan into biannual education days designed for current staff nurses, as well as into the orientation plan for newly hired and student nurses.
Synthesis, Self-Assembly and Solution-Processed Field-Effect Transistors of a Liquid Crystalline Bis(dithienothiophene) Derivative (2009)

A new liquid crystalline dithienothiophene dimer cap-functionalized with 3,4,5-tris-n-dodecyloxyphenyl groups (1) has been synthesized. The absorption spectrum blue-shifts 7 nm, while the fluorescence spectrum red-shifts 95 nm in thin film with respect to that in solution, suggesting that H-aggregate formation may occur and the molecules are cofacially aligned in the solid state. Compound 1 self-organized into highly ordered, long-range 2-dimensional nanopatterns on highly oriented pyrolytic graphite; their structures were characterized by scanning tunneling microscopy. The liquid crystalline phase was formed upon heating or cooling and was investigated using differential scanning calorimetry and polarizing optical microscopy. Thermal annealing led to a 13 nm red shift of absorption spectra of 1 in the thin film, indicating liquid crystalline enhanced ordering. Solution-processed organic field-effect transistors based on 1 exhibited a mobility of 1.7 × 10−3 cm2 V−1 s−1 and an on/off ratio of 2 × 105.
WLC17-5: Improving Mobile Station Energy Efficiency in IEEE 802.16e WMAN by Burst Scheduling (2006)

In this paper, we tackle the packet scheduling problem in IEEE 802.16e wireless metropolitan area network (WMAN), where the Sleep Mode is applied to save energy of mobile stations (MSs). Our objective is to design an energy efficient scheduling policy which works closely with the sleep mode mechanism so as to maximize battery lifetime in MSs. To the best of our knowledge no power saving scheduling algorithms based on sleep mode defined in IEEE 802.16e have been proposed so far in the literature. We propose a longest virtual burst first (LVBF) scheduling algorithm which schedules packets of MSs in a virtual burst mode where there is one primary MS and multiple secondary MSs sharing the wireless link resource. LVBF prolongs MSs' lifetime by reducing the average time when MSs stay in the idle state and the number of state transitions between the awake and sleep states. Simulation results show that, in comparison with the round robin scheduling scheme, LVBF can produce significant overall energy saving, while guaranteeing the QoS requirements of MSs in terms of their minimum data rates.
国際理解と学校音楽教育―「郷土のこもりうた」から「世界のこもりうた」へ― (2002)

本研究は、学校教育の今日的課題の一つである国際理解を取り上げ、学校音楽教育が国際理解にどのように貢献しうるのかを検討するものである。音・歌・音楽は、グローバル教育の視点から捉えられることが必要であると考える。そのためには音楽を文化として体験し、生活における音楽の持つ意味を理解することが必要である。学習パラダイムとして、自文化の音楽を理解し、その上で異文化である諸民族の音楽を体験・理解するという段階が考えられる。そこで本研究では、①音楽科における国際理解についての認識と、これまでの教育実践について検討を行い、そこにみられる問題を指摘し、②世界のどの民族にも存在する「こもりうた」を取り上げ、文化的・音楽的特徴を明らかにした上で、それを適用した具体的な学習方法を提示した。
EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin (2004)

The lethality of infection by Bacillus anthracis is largely due to its plasmid-encoded toxins, which consist of a carrier protein, the protective antigen (PA), in combination with either the lethal-factor or edema-factor moiety. During B. anthracis infections, PA secreted by bacteria binds to membrane receptors of susceptible cells, is cleaved proteolytically, attaches to lethal factor or edema factor, undergoes oligomerization and internalization, and transports its toxin partners to acidic endosomes where they are released into the cytosol. To identify specific host functions that mediate these events, we used RNA encoded by a lentivirus-based library of approximately 40,000 human ESTs to inactivate chromosomal genes in a human cell population, and we isolated clones that survived PA-dependent toxin-induced death. This phenotypic screen and subsequent analysis identified ARAP3, which is a phosphoinositide-binding protein implicated previously in membrane vesicle trafficking and cytoskeletal organization, as a mammalian host-cell gene that is essential for normal anthrax toxicity. ARAP3 deficiency produced by antisense expression of an ARAP3 EST impaired entry of PA and its bound toxigenic moieties into both human and mouse cells, resulting in reduced toxin sensitivity. Our results demonstrate the usefulness of antisense EST libraries for global chromosomal gene inactivation, establish the practicality of loss-of-function phenotypic screens for the identification of genomic loci required for pathogen effects in mammalian cells, and reveal an important role for ARAP3 in cellular internalization of anthrax toxin.
Revistas latinoamericanas y su presencia en las bibliotecas de la UNAM (2004)

El artículo aborda la problemática por la que han atravesado las publicaciones periódicas latinoamericanas en cuanto a su irregularidad en la frecuencia, falta de control bibliográfico, difusión y distribución limitadas, barrera idiomática y baja producción de trabajos en revistas locales por parte de los investigadores. Se aborda también la poca presencia de las revistas latinoamericanas en el Sistema Bibliotecario de la Universidad Nacional Autónoma de México (unam), apoyados en un análisis que se realizó en la Hemeroteca Latinoamericana de la unam, el Sistema latindex, el Catálogo seriunam y el Índice de Revistas Mexicanas de Investigación Científica y Tecnológica del Consejo Nacional de Ciencia y Tecnología (conacyt) de México. Asimismo, se ofrece un análisis sobre el tipo de editorial que publica las revistas del Índice del conacyt.
Integration of material and process modelling in a business decision support system: Case of COMPOSELECTOR H2020 project (2018)

This paper shares and contributes to a ground-breaking vision developed and being implemented which consists in the integration of materials modelling methodologies and knowledge-based systems with business process for decision making. The proposed concept moves towards a new paradigm of material and process selection and design by developing and implementing an integrated multi-disciplinary, multi-model and multi-field approach together with its software tool implementation for an accurate, reliable, efficient and cost effective prediction, design, fabrication, Life Cycle Engineering (LCE), cost analysis and decision making. This new paradigm of integrated material design is indeed endowed with a great potential by providing further insights that will promote further innovations on a broad scale.
Cementing democracy: In Mozambique (1995)

Abstract The success of the United Nations peacekeeping operation in Mozambique in establishing the conditions for the rebuilding of a country devastated by 16 years of civil war is assessed. Difficulties were encountered in both the military and electoral phases of the operation. But these were overcome and the UN's Special Representative, Aldo Ajello, had good cause for satisfaction on the completion of his mission in December 1994. However, in the longer term, weaknesses of key components of democracy in Mozambique, such as the effectiveness of the legislature and of the judicial system and the independence of the media, mean that the future of democracy is far from being assured.
Genetic Alterations and Aberrant Expression of Genes Related to the Phosphatidyl‐lnositol‐3′‐Kinase/Protein Kinase B (Akt) Signal Transduction Pathway in Glioblastomas (2003)

Glioblastomas frequently carry mutations in the PTEN tumor suppressor gene on 10q23.3. The tumor suppressor properties of Pten are closely related to its inhibitory effect on the phosphatidyl-inositol-3'-kinase (Pi3k)-dependent activation of protein kinase B (Akt) signalling. Here, we report on the analysis of 17 genes related to the Pi3k/Akt signalling pathway for genetic alteration and aberrant expression in a series of 103 glioblastomas. Mutation, homozygous deletion or loss of expression of PTEN was detected in 32% of the tumors. In contrast, we did not find any aberrations in the inositol polyphosphate phosphatase like-1 gene (INPPL1), whose gene product may also counteract Pi3k-dependent Akt activation. Analysis of genes encoding proteins that may activate the pathway upstream of Pi3k revealed variable fractions of tumors with EGFR amplification (31%), PDGFRA amplification (8%), and IRS2 amplification (2%). The protein tyrosine kinase 2 (PTK2/FAK1) gene was neither amplified nor overexpressed at the mRNA level. Investigation of three genes encoding catalytic subunits of Pi3k (PIK3CA, PIK3CD, and PIK3C2B) revealed amplification of PIK3C2B (1q32) in 6 tumors (6%). Overexpression of PIK3C2B mRNA was detected in 4 of these cases. PIK3CD (1p36.2) and PIK3CA (3q26.3) were not amplified but PIK3CD mRNA was overexpressed in 6 tumors (6%). Amplification and overexpression of AKT1 was detected in a single case of gliosarcoma. The IRS1, PIK3R1, PIK3R2, AKT2, AKT3, FRAP1, and RPS6KB1 genes were neither amplified nor overexpressed in any of the tumors. Taken together, our data indicate that different genes related to the Pi3k/Akt signalling pathway may be aberrant in glioblastomas.
13C-nuclear magnetic resonance (NMR) spectra of O-acylglucoses. Additivity of shift parameters and its application to structure elucidations. (1980)

CMR spectra of all positional isomers of mono-O-myristoyl-α- and β-D-glucopyranoses in pyridine-d5 are reported and discussed in connection with the anomalies of 1α- and 1β-O-acyl derivatives. Calculation of the chemical shifts of some dimyristates using the acylation shifts obtained from monomyristate (Table III) gave values in agreement with the observed values for each compound, confirming the additivity of the acylation shift parameters. The effects of the solvent and the nature of the acyl moiety on the acylation shifts also examined using twenty samples, and it was concluded that the acylation shift parameters are independent of the solvent (s) and the kind (s) of acyl group (s), so that the above shift values obtained for the myristoyl group can be regarded as a universal set of additive parameters for usual di- and tri-acyl derivatives. This additivity rule of parameters was successfully applied to the structure elucidation of two naturally occurring acylglucose derivatives, tuliposide-A and spirarin. The previously reported data for various glucosyl γ-nitropropanoates in acetone-d5 are compared with the values calculated from the above parameters, again showing fair agreement.
Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats (2004)

Since the study of induction of the antioxidant enzymes is considered to be a reliable marker for evaluating the antiperoxidative efficacy of the medicinal plant, these findings suggest a possible antiperoxidative role for Scoparia dulcis plant extract. Hence, in addition to antidiabetic effect, Scoparia dulcis possess antioxidant potential that may be used for therapeutic purposes.
Electronic Document Security Sharing System Based on Lineage Mechanism (2008)

That ensuring the electronic documents security is the key to the protection of internal information. With the extent of file sharing enlarged, it is hard to keep balance between the security and sharing. To achieve this goal, file tracing and audit, dynamic adjustment of right must be solved better. In this paper, a electronic document security system based on lineage mechanism is proposed,it support dynamic adjust right in mutable environment. It implement the file trace through recording the access logs and path of transmission. In fact, it implement one of the UCON models: pre-authorization with post update.
Interactions between components of complex fertilizers (2019)

The book addresses the issues of chemical and physico-chemical interaction occurring in multicomponent water-salt systems, which are formed at separate stages of the production of complex NP and NPK fertilizers, including gray and magnesium-containing fertilizers. Particular attention is paid to chemical interactions between the individual components, occurring at the stages of granulation and drying, depending on the method and types of input nitrogen, potassium and magnesium-containing components. The book is intended for specialists of industrial enterprises of mineral fertilizers and design organizations, researchers, graduate students and students engaged in the field of chemical technology of inorganic substances.
Separability of time-frequency synchronization (2013)

Recently proposed new time synchronization using frequency domain (FD) integration and time domain (TD) spread spectrum (SS) codes has been shown to be robust to frequency offset, that has its dual frequency synchronization using TD integration and FD SS codes which is robust to timing offset. Separable property (SP) is defined for time-frequency synchronization under the condition containing time and frequency deviations is to be performed separately and cooperatively. The SP comples us to design phase corrections on SS codes and transmitted data.