gebhart/patrepeval huggingface dataset:
Electrolytes with Improved Safety Characteristics for High Voltage, High Specific Energy Li-ion Cells (2012)

(1) NASA is actively pursuing the development of advanced electrochemical energy storage and conversion devices for future lunar and Mars missions; (2) The Exploration Technology Development Program, Energy Storage Project is sponsoring the development of advanced Li-ion batteries and PEM fuel cell and regenerative fuel cell systems for the Altair Lunar Lander, Extravehicular Activities (EVA), and rovers and as the primary energy storage system for Lunar Surface Systems; (3) At JPL, in collaboration with NASA-GRC, NASA-JSC and industry, we are actively developing advanced Li-ion batteries with improved specific energy, energy density and safety. One effort is focused upon developing Li-ion battery electrolyte with enhanced safety characteristics (i.e., low flammability); and (4) A number of commercial applications also require Li-ion batteries with enhanced safety, especially for automotive applications.
Genome-wide association across <i>Saccharomyces cerevisiae</i> strains reveals substantial variation in underlying gene requirements for toxin tolerance (2017)

Abstract Cellulosic plant biomass is a promising sustainable resource for generating alternative biofuels and biochemicals with microbial factories. But a remaining bottleneck is engineering microbes that are tolerant of toxins generated during biomass processing, because mechanisms of toxin defense are only beginning to emerge. Here, we exploited natural diversity in 165 Saccharomyces cerevisiae strains isolated from diverse geographical and ecological niches, to identify mechanisms of hydrolysate-toxin tolerance. We performed genome-wide association (GWA) analysis to identify genetic variants underlying toxin tolerance, and gene knockouts and allele-swap experiments to validate the involvement of implicated genes. In the process of this work, we uncovered a surprising difference in genetic architecture depending on strain background: in all but one case, knockout of implicated genes had a significant effect on toxin tolerance in one strain, but no significant effect in another strain. In fact, whether or not the gene was involved in tolerance in each strain background had a bigger contribution to strain-specific variation than allelic differences. Our results suggest a major difference in the underlying network of causal genes in different strains, suggesting that mechanisms of hydrolysate tolerance are very dependent on the genetic background. These results could have significant implications for interpreting GWA results and raise important considerations for engineering strategies for industrial strain improvement. Author summary Understanding the genetic architecture of complex traits is important for elucidating the genotype-phenotype relationship. Many studies have sought genetic variants that underlie phenotypic variation across individuals, both to implicate causal variants and to inform on architecture. Here we used genome-wide association analysis to identify genes and processes involved in tolerance of toxins found in plant-biomass hydrolysate, an important substrate for sustainable biofuel production. We found substantial variation in whether or not individual genes were important for tolerance across genetic backgrounds. Whether or not a gene was important in a given strain background explained more variation than the alleleic differences in the gene. These results suggest substantial variation in gene contributions, and perhaps underlying mechanisms, of toxin tolerance.
Development of limb volume measuring system (1983)

The mechanisms underlying the reductions in orthostatic tolerance associated with weightlessness are not well established. Contradictory results from measurements of leg volume changes suggest that altered venomotor tone and reduced blood flow may not be the only contributors to orthostatic intolerance. It is felt that a more accurate limb volume system which is insensitive to environmental factors will aid in better quantification of the hemodynamics of the leg. Of the varous limb volume techniques presently available, the ultrasonic limb volume system has proven to be the best choice. The system as described herein is free from environmental effects, safe, simple to operate and causes negligible radio frequency interference problems. The segmental ultrasonic ultrasonic plethysmograph is expected to provide a better measurement of limb volume change since it is based on cross-sectional area measurements.
Stable and Selective Formation of Hoogsteen-Type Triplexes and Duplexes Using Twisted Intercalating Nucleic Acids (TINA) Prepared via Postsynthetic Sonogashira Solid-Phase Coupling Reactions (2005)

Bulge insertions of (R)-1-O-[4-(1-pyrenylethynyl)phenylmethyl]glycerol (5) into the middle of homopyrimidine oligodeoxynucleotides (twisted intercalating nucleic acids, TINA) obtained via postsynthetic Sonogashira coupling reaction led to extraordinary high thermal stability of Hoogsteen-type triplexes and duplexes, whereas Watson-Crick-type duplexes of the same nucleotide content were destabilized. Modified oligonucleotides were synthesized using the phosphoramidite of (S)-1-(4,4'-dimethoxytriphenylmethyloxy)-3-(4-iodo-benzyloxy)-propan-2-ol followed by treatment of the oligonucleotide on a CPG-support with the Sonogashira-coupling reaction mixture containing different ethynylaryls. Bulged insertion of the pyrene derivative 5 into oligonucleotides was found to be the best among the tested modifications for binding to the Hoogsteen-type triplexes and duplexes. Thus, at pH 7.2 an oligonucleotide with cytidine content of 36% possessing two bulged insertions of 5 separated by three bases formed a stable triplex (T(m) = 43.0 degrees C), whereas the native oligonucleotide was unable to bind to the target duplex. The corresponding Watson-Crick-type duplex with the same oligonucleotide had T(m) of 38.0 degrees C at pH 7.2, while the T(m) of unmodified dsDNA was 47.0 degrees C. Experiments with mismatched oligonucleotides, luminescent properties, and potential applications of TINA technology is discussed.
Perpendicular magnetic recording: Playback (2005)

For the past several years, perpendicular magnetic recording has been under intense scrutiny as the primary alternative to magnetic data storage technologies in place today. Major system components, write heads and media in particular, have been the subject of extensive studies. Less attention, however, has been devoted to the playback processes in perpendicular recording systems. The playback heads used in technology demonstrations remain largely unchanged from their longitudinal recording counterparts. It is an open question whether the longitudinal playback-head design is optimal for perpendicular recording. For example, application of longitudinal playback heads in perpendicular recording leads to undesirable phenomena associated with modified playback response, increased flying height sensitivity, adjacent track interference, and calls for major modifications of the existing read channels. The subject of this work is a detailed discussion of the playback physics, in perpendicular recording systems; the focus being to establish the design guidelines for optimized perpendicular playback heads, which are equivalent or superior in their performance characteristics to conventional shielded readers used in longitudinal recording. Conformal mapping is applied to demonstrate the playback wave form equivalency between a shielded and dual-pole readers when applied in longitudinal and perpendicular recording, respectively. Utilizing extensive three-dimensional modeling and reciprocity principle to evaluate the performance of various playback-head configurations, it is demonstrated that differential reader configurations possess advantageous playback characteristics, such as higher playback amplitude, improved spatial resolution, and reduced dependence on flight-height variations as compared to conventional shielded readers. Modified design of differential readers with a single magnetoresistive sensor is proposed to overcome the manufacturability issues associated with a conventional dual-sensor differential reader.
<i>Francisella asiatica</i> as the causative agent of piscine francisellosis in cultured tilapia (<i>Oreochromis</i> sp.) in the United States (2011)

Francisella asiatica is a Gram-negative, pleomorphic, facultative intracellular, bacterial pathogen that causes acute to chronic disease in a wide variety of warm-water cultured and wild fish species. Outbreaks of francisellosis in warm water fish have been documented in Taiwan, Japan, United Kingdom, Hawaii, and Latin America (including Costa Rica) but the organism has only been reported from the United States on one occasion from hybrid striped bass in California. In 2010, the bacterium was detected from diseased tilapia by culture on cystine heart agar supplemented with hemoglobin and by utilizing an F. asiatica-specific real-time polymerase chain reaction assay. The tilapia (Oreochromis niloticus) were cultured in an indoor, closed, recirculating aquaculture facility in the Midwest of the United States. The identity of isolates recovered from diseased fish was confirmed as F. asiatica by amplification and sequence comparison of the 16S ribosomal RNA and intracellular growth locus C (iglC) gene. Gross and microscopic examination of affected tissues revealed the presence of marked anterior renomegaly and splenomegaly with severe granulomatous disease.
Introduction: Intraoperative manipulation, reduction, realignment, and deformity reduction in patients with atlantoaxial dislocation and basilar invagination (2020)

"Introduction: Intraoperative manipulation, reduction, realignment, and deformity reduction in patients with atlantoaxial dislocation and basilar invagination" published on Jul 2020 by American Association of Neurological Surgeons.
Erythropoietin‐mediated tissue protection: reducing collateral damage from the primary injury response (2008)

In its classic hormonal role, erythropoietin (EPO) is produced by the kidney and regulates the number of erythrocytes within the circulation to provide adequate tissue oxygenation. EPO also mediates other effects directed towards optimizing oxygen delivery to tissues, e.g. modulating regional blood flow and reducing blood loss by promoting thrombosis within damaged vessels. Over the past 15 years, many unexpected nonhaematopoietic functions of EPO have been identified. In these more recently appreciated nonhormonal roles, locally-produced EPO signals through a different receptor isoform and is a major molecular component of the injury response, in which it counteracts the effects of pro-inflammatory cytokines. Acutely, EPO prevents programmed cell death and reduces the development of secondary, pro-inflammatory cytokine-induced injury. Within a longer time frame, EPO provides trophic support to enable regeneration and healing. As the region immediately surrounding damage is typically relatively deficient in endogenous EPO, administration of recombinant EPO can provide increased tissue protection. However, effective use of EPO as therapy for tissue injury requires higher doses than for haematopoiesis, potentially triggering serious adverse effects. The identification of a tissue-protective receptor isoform has facilitated the engineering of nonhaematopoietic, tissue-protective EPO derivatives, e.g. carbamyl EPO, that avoid these complications. Recently, regions within the EPO molecule mediating tissue protection have been identified and this has enabled the development of potent tissue-protective peptides, including some mimicking EPO's tertiary structure but unrelated in primary sequence.
Optical Polarization Characteristics of InGaN Quantum Wells for Green Laser Diodes on Semi-Polar {20\bar21} GaN Substrates (2010)

The polarization characteristics of InGaN quantum wells on semi-polar {2021} GaN substrates were investigated to reveal the advantageous laser stripe orientation. The polarization ratio exhibited a gradual increase within the range of around 0.2 to 0.3 with an increase in the emission wavelength from 400 to 550 nm under a low current density of 7.4 A/cm2. In addition, the dependence on a current density was quite small up to 0.74 kA/cm2. These results suggest that the laser stripe perpendicular to the a-axis direction is favorable for green laser diodes.
Recombinant <i>Fasciola hepatica</i> fatty acid binding protein (Fh15) as a novel anti-inflammatory biotherapeutic in an acute gram-negative non-human primate sepsis model (2022)

Abstract Due to their phylogenetic proximity to human, non-human primates are considered an adequate choice for basic and pre-clinical model of sepsis. Gram-negative bacteria are the primary causative of sepsis. During infection, bacteria continuously release the potent toxin lipopolysaccharide (LPS) into the bloodstream, which triggers an uncontrolled systemic inflammatory response leading to death. Our previous research has demonstrated in vitro and in vivo using a mouse model of septic shock that Fh15, a recombinant variant of the Fasciola hepatica fatty acid binding protein, acts as an antagonist of TLR4 suppressing the LPS-induced pro-inflammatory cytokine storm. The present communication is a proof-of concept study aimed to demonstrate that a low-dose of Fh15 suppresses the cytokine storm and other inflammatory markers during the early phase of sepsis induced in rhesus macaques by i.v. infusion with lethal doses of live E. coli. Fh15 was administrated as isotonic infusion 30 min prior to the bacterial infusion. Among the novel findings reported in this communication, I) Fh15 significantly prevented bacteremia, suppressed LPS levels in plasma and the production of C-reactive protein and procalcitonin, which are key signature of inflammation and bacterial infection, respectively, II) reduced the production of pro-inflammatory cytokines, and III) increased innate immune cell populations in blood, which suggest a role in promoting a prolonged steady state in rhesus macaques even in the presence of inflammatory stimuli. This is the first report demonstrating that a F. hepatica-derived molecule possesses potential as anti-inflammatory drug against sepsis in an NHP-model. This research was supported by the National Institute of Allergy and Infectious Diseases Grant/Award Number: 1SC1AI155439-01, Office of Research Infrastructure Program of NIH (ORIP-NIH) 2016-2021, Grant/Award Number: P40OD12271; National Institute on Minorities Health and Health Disparities, Grant/Award Number: 5R25GM061151, G12MD007600 and R25GM061838.
T Cell Intrinsic Heterodimeric Complexes between HVEM and BTLA Determine Receptivity to the Surrounding Microenvironment (2009)

The inhibitory cosignaling pathway formed between the TNF receptor herpesvirus entry mediator (HVEM, TNFRSF14) and the Ig superfamily members, B and T lymphocyte attenuator (BTLA) and CD160, limits the activation of T cells. However, BTLA and CD160 can also serve as activating ligands for HVEM when presented in trans by adjacent cells, thus forming a bidirectional signaling pathway. BTLA and CD160 can directly activate the HVEM-dependent NF-kappaB RelA transcriptional complex raising the question of how NF-kappaB activation is repressed in naive T cells. In this study, we show BTLA interacts with HVEM in cis, forming a heterodimeric complex in naive T cells that inhibits HVEM-dependent NF-kappaB activation. The cis-interaction between HVEM and BTLA is the predominant form expressed on the surface of naive human and mouse T cells. The BTLA ectodomain acts as a competitive inhibitor blocking BTLA and CD160 from binding in trans to HVEM and initiating NF-kappaB activation. The TNF-related ligand, LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes, or TNFSF14) binds HVEM in the cis-complex, but NF-kappaB activation was attenuated, suggesting BTLA prevents oligomerization of HVEM in the cis-complex. Genetic deletion of BTLA or pharmacologic disruption of the HVEM-BTLA cis-complex in T cells promoted HVEM activation in trans. Interestingly, herpes simplex virus envelope glycoprotein D formed a cis-complex with HVEM, yet surprisingly, promoted the activation NF-kappaB RelA. We suggest that the HVEM-BTLA cis-complex competitively inhibits HVEM activation by ligands expressed in the surrounding microenvironment, thus helping maintain T cells in the naive state.
Dual-time-point Patlak estimation from list mode PET data (2012)

We investigate the potential of using dual-time-point PET data to perform Patlak modeling. If successful this approach could be used for whole-body dynamic PET in which we compute voxel-wise estimates of Patlak parameters using two frames of data for each bed position. Our approach directly uses list-mode arrival time for each event to compute the Patlak image. We evaluate performance of the method in comparison to fractional changes in SUV values computed from the same two frames of data. The area under ROC curves is used as a figure of merit to assess the relative performance of these two approaches in differentiating tumor from background. We calculate ROC curves using (i) variance estimates computed from the Cramer-Rao bound for a simplified 1D version of the problem and (ii) 4D Monte Carlo simulations of tumors with a range of sizes in a uniform background. Both the simulation and Cramer-Rao analysis suggest that our dual-time-point Patlak estimation method can achieve superior differentiation of tumor from background in small tumors compared to using fractional changes in SUV computed from the same dual-time-point data.
Zero-Cost, Fine-Grained Power Monitoring of Datacenters Using Non-Intrusive Power Disaggregation (2015)

Fine-grained power monitoring, which refers to power monitoring at the server level, is critical to the efficient operation and energy saving of datacenters. Fined-grained power monitoring, however, is extremely challenging in legacy datacenters that host server systems not equipped with power monitoring sensors. Installing power monitoring hardware at the server level not only incurs high costs but also complicates the maintenance of high-density server clusters and enclosures. In this paper, we present a zero-cost, purely software-based solution to this challenging problem. We use a novel technique of non-intrusive power disaggregation (NIPD) that establishes power mapping functions (PMFs) between the states of servers and their power consumption, and infer the power consumption of each server with the aggregated power of the entire datacenter. We implement and evaluate NIPD over a real-world datacenter with 326 nodes. The results show that our solution can provide high precision power estimation at the rack level, with mean relative error of 2.63%, and the server level, with mean relative error of 10.27% and 8.17% for the estimation of idle power and peak power, respectively.
Gamma-Sensitive Self-Powered Detectors and Their Use for in-Core Flux-Mapping (1981)

In-core gamma sensitive self-powered detectors have desirable characteristics such as instantaneous response and low burnup, but they do not directly measure the thermal neutron flux. Their usefulness thus depends on how well the in-core gamma flux distribution follows that of the thermal neutton flux, or more precisely how the distribution in the detector current follows that of the thermal neutron flux. To determine the behavior of these detectors we have computed the response of Pt and Pt-clad Inconel self-powered detectors to gammas from .1 to 8 MeV including the effect of recoil electrons produced in the surrounding material. Using these results and gamma spectra obtained from reactor design calculations the distributions over a PWR core of the current from each detector was determined and compared with that of the thermal neutron flux. The comparison showed that the distributions from either detector and the thermal neutron flux remained consistent within about 5% over most of the core but deviations of 10-15% occurred near the radial boundary of the core and 20-30% occurred at the very top and bottom. Thus a single calibration constant can be used to relate detector current to neutron flux for all the self-powered detectors in the core except those located very near the core boundaries.
Pulse Operation of a Floating-Electrode Memristive Device (2013)

A resistive device with a floating electrode is manufactured as a stack of layers Cu/TaO <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</i> /Pt/TaO <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</i> /Cu in a crossbar array comprising two single resistive switches antiserially merged at the common inert floating electrode. The device exhibits four states, namely, HRS/HRS, HRS/LRS, LRS/HRS, and LRS/LRS, where HRS and LRS are the high- and low-resistance states of a single switch. During transitions between the states, the lifetime of the LRS/LRS state can be rendered very short. This property lends itself to generation of current/voltage pulses that can be controlled by three independent technology parameters.
Interference Minimization in Cooperative Relay Beamforming With Multiple Communicating Pairs (2017)

We consider a cellular network where each cell contains multiple source-destination pairs communicating through multiple amplify-and-forward relays using orthogonal channels. We propose an optimal relay beamforming design that minimizes the maximum interference at the neighboring cells subject to per-relay power limits and minimum received signal-to-noise ratio (SNR) requirements. Even though the problem is non-convex, we show that it has zero Lagrange duality gap, and we convert its dual problem to a semi-definite programming problem. Depending on the values of the optimal dual variables, we study three cases to obtain the optimal beam vectors accordingly. This results in an iterative algorithm that provides a semi-closed-form optimal solution. We extend our algorithm to the problem of maximizing the minimum SNR subject to some pre-determined maximum interference constraints at neighboring cells, by the solution to the min-max interference problem along with a bisection search. The solution to this max-min SNR problem gives insight into the worst-case signal-to-interference-and-noise ratio given some maximum interference target. The performance of the proposed algorithm is studied numerically, both for when the knowledge of interference channel is perfect and for when it is imperfect due to either limited feedback or channel estimation error.
Principles of Designing Extra-Large Pore Openings and Cages in Zeolitic Imidazolate Frameworks (2017)

We report three design principles for obtaining extra-large pore openings and cages in the metal-organic analogues of inorganic zeolites, zeolitic imidazolate frameworks (ZIFs). Accordingly, we prepared a series of 15 ZIFs, members of which have the largest pore opening (22.5 Å) and the largest cage size (45.8 Å) known for all porous tetrahedral structures. The key parameter allowing us to access these exceptional ZIFs is what we define as the steric index (δ), which is related to the size and shape of the imidazolate linkers employed in the synthesis. The three principles are based on using multiple linkers with specific range and ratios of δ to control the size of rings and cages from small to large, and therefore are universally applicable to all existing ZIFs. The ZIF with the largest cage size (ZIF-412) shows the best selectivity of porous materials tested toward removal of octane and p-xylene from humid air.
Differential phase shift quantum key distribution with up-conversion single-photon detectors (2006)

A differential phase shift quantum key distribution experiment employing up-conversion single-photon detectors is presented. We achieved a 1-Mbit/s sifted key rate over a 20-km optical fiber, and distributed keys secure against general individual attacks over 75 km