gebhart/patrepeval huggingface dataset:
Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes (2018)

Obesity is a nutritional disorder resulting from a chronic imbalance between energy intake and expenditure. This disease is characterized by inflammation in multiple cell types, including macrophages. M1 macrophage responses are correlated with the progression of obesity or diabetes; therefore, strategies that induce repolarization of macrophages from an M1 to an M2 phenotype may be promising for the prevention of obesity- or diabetes-associated pathology. Glutamine (the most abundant amino acid in the plasma of humans and many other mammals including rats) is effective in inducing polarization of M2 macrophages through the glutamine-UDP-N-acetylglucosamine pathway and α-ketoglutarate produced via glutaminolysis, whereas succinate synthesized via glutamine-dependent anerplerosis or the γ-aminobutyric acid shunt promotes polarization of M1 macrophages. Interestingly, patients with obesity or diabetes show altered glutamine metabolism, including decreases in glutamine and α-ketoglutarate concentrations in serum but increases in succinate concentrations. Thus, manipulation of macrophage polarization through glutamine metabolism may provide a potential target for prevention of obesity- or diabetes-associated pathology.
Evaluation of atoxigenic isolates of<i>Aspergillus flavus</i>as potential biocontrol agents for aflatoxin in maize (2008)

Aflatoxin contamination resulting from maize infection by Aspergillus flavus is both an economic and a public health concern. Therefore, strategies for controlling aflatoxin contamination in maize are being investigated. The abilities of eleven naturally occurring atoxigenic isolates in Nigeria to reduce aflatoxin contamination in maize were evaluated in grain competition experiments and in field studies during the 2005 and 2006 growing seasons. Treatments consisted of inoculation of either grains in vials or ears at mid-silking stage in field plots, with the toxigenic isolate (La3228) or atoxigenic isolate alone and co-inoculation of each atoxigenic isolate and La3328. Aflatoxin B(1) + B(2) concentrations were significantly (p < 0.05) lower in the co-inoculation treatments compared with the treatment in which the aflatoxin-producing isolate La3228 was inoculated alone. Relative levels of aflatoxin B(1) + B(2) reduction ranged from 70.1% to 99.9%. Among the atoxigenics, two isolates from Lafia, La3279 and La3303, were most effective at reducing aflatoxin B(1) + B(2) concentrations in both laboratory and field trials. These two isolates have potential value as agents for the biocontrol of aflatoxin contamination in maize. Because these isolates are endemic to West Africa, they are both more likely than introduced isolates to be well adapted to West African environments and to meet regulatory concerns over their use throughout that region.
A sequence pattern for peptides presented to cytotoxic T lymphocytes by HLA B8 revealed by analysis of epitopes and eluted peptides (1993)

HLA B8-restricted cytotoxic T lymphocytes (CTL) specific for influenza A virus were generated and shown to recognize the nucleoprotein (NP). The dominant epitope was mapped using recombinant vaccinia viruses that expressed fragments of the NP and then synthetic peptides based on the NP amino acid sequence. The peptide 380-393 was first identified and further refined; it was shown that the glutamic acid at position 380 was essential for recognition by CTL and that the nonamer 380-388 was the optimum peptide. Six HLA B8-positive influenza immune donors that we have tested respond to this peptide as part of their influenza-specific CTL response. The amino acid sequence of the peptide epitope was compared to six other known virus peptides known to be restricted by HLA B8 and a sequence homology was identified, which predicted nonamer and octamer epitope sequences. Probable anchor residues were identified at peptide residues 3 (lysine/arginine), 5 (lysine/arginine) and 9 (leucine/isoleucine). Support for this pattern came from sequencing peptides eluted from purified HLA B8 molecules, where lysines were predominant at positions 3 and 5. One of the predicted epitope peptides was made and shown to be recognized by specific CTL. These and the two others were shown to compete with NP 380-388 for binding to HLA B8. A model was made of the HLA B8 molecule and negatively charged pockets predicted, which could accommodate the positively charged side chains of the peptide anchor residues.
The present and future of drug-eluting stents. (2005)

The only widely accepted way to reduce restenosis rate after percutaneous balloon angioplasty has been the use of coronary bare metal stents, and the last decade has witnessed a prompt and widespread adoption of bare metal stents that has revolutionized the field of interventional cardiology. The new millennium has seen the recent development of drug-eluting stents (DES), allowing controlled release of a drug directly to the injured artery, which seem to have prevented by large the problem of in-stent restenosis. The goal of this review was to summarize recent laboratory and clinical investigations concerning the effects of DES in various settings relevant to coronary heart disease. In the experimental setting, we examine the intracellular signaling and the role of smooth muscle cells after vascular injury. We also discuss recent observations from our laboratory showing the effects of coating per se on cell apoptosis and proliferation. In the clinical setting, the effects of DES in patients with stable or unstable angina pectoris is examined in detail for the relevant implications both in the treatment and prognosis. The results of a meta-analysis on the effects that have been overlooked in individual studies are reported which show a striking reduction in bypass surgery after DES implantation. Finally, we discuss the potential role of new materials and technologies (i.e., nanotechnology) that will improve DES performance allowing other future clinical applications in patients with ST-elevation myocardial infarction, vulnerable plaques, insulin-dependent diabetes mellitus, etc.
Human Papillomavirus G-Quadruplexes (2013)

Infection with human papillomaviruses (HPVs) is one of the most common sexually transmitted infections and can lead to development of head and neck, skin, and anogenital cancer, including cervical cancer, which represents one of the world's most significant health problems. In this study, we analyze G-rich regions in all known HPV genomes in order to evaluate their potential to fold into G-quadruplex structure. Interestingly, G-rich loci fulfilling the criteria for G-quadruplex formation were found in only 8 types of HPV. Nevertheless, viral G-quadruplexes in 7 sequences derived directly from HPVs are confirmed here for the first time. G-rich regions with the capacity to form G-quadruplexes are located in the LCR, L2, E1, and E4 regions of the HPV genome; therefore we assume that regulation processes in viruses could be affected by G-quadruplex formation. Our results represent a starting point for the design of specific ligands with viral G-quadruplex motifs and suggest novel methods for the control of viral replication and transcription.
Influences of copolymer polyol on structural and viscoelastic properties in molded flexible polyurethane foams (2000)

In this study, the viscoelastic and morphological properties of molded foams were investigated to determine the influence of the presence or absence of reinforcing particulate copolymer polyols (CPP). The molded foams were based on toluene diisocyanate (TDI) and glycerol-initiated ethylene-oxide endcapped polypropylene oxide and, in most samples, some amount of copolymer polyol. Two series of foams were studied. In Series 1, as CPP is added to the formulation, the amount of TDI fed is kept constant. This results in a constant amount of hard-segment content as the filler in the system displaces, by weight, the polyether polyol in the foam, and it increases the hard segment to soft segment ratio (HS/SS). In Series 2, the amount of hard-segment material is proportionally decreased as CPP is added, resulting in a constant HS/SS ratio. Structural investigations of the foams displayed rather similar textures. The cellular structures of a CPP-containing foam was very similar to a foam lacking the copolymer polyols. Transmission electron microscopy revealed that the CPP particles were well dispersed and that they possessed significant rigidity even at high temperature and under high compression. Although all of the foams were microphase-separated, they varied slightly in that the copolymer polyol containing foams exhibited higher weight fractions of extractables in both Series 1 and Series 2. This suggests that not all of the CPP material is covalently bonded into the polyol matrix. It was found that temperatures above ambient as well as humidity plasticized the viscoelastic behavior of all the molded foams evaluated. It was also found that the copolymer polyol particles, as added to the molded foams of Series 1, increased load-bearing capabilities but had a negative effect on the stress relaxation, creep, and compression set properties. In particular, the viscoelastic properties of the CPP-containing foam were distinctly more time-dependent than those of the foam lacking these particles. However, the Series 2 foams show that most of these effects are a result of the increased HS/SS ratio and not a result of the CPP particulate. It was shown that adding CPP while maintaining a constant HS/SS ratio improves percent load loss and load bearing under high-humidity conditions, two important properties in flexible polyurethane foams. Finally, it was shown that at high temperatures (ca. 100°C), an additional relaxation mechanism occurs which cannot be attributed to changes in the HS/SS ratio, but must be a result of the CPP components themselves. This additional mechanism results in higher rates of load relaxation and creep in foams containing CPP at high temperatures for foams of both series. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 78: 766–786, 2000
Evaluation of Gas Turbine Outboard Bleed Air on Overall Engine Efficiency and CO2e Emission in Natural Gas Compressor Stations (2013)

Gas turbine (GT) engines employed in natural gas compressor stations operate in different modes depending on the power, turbine inlet temperature, and shaft speeds. These modes apply different sequencing of bleed valve opening on the air compressor side of the engine. Improper selection of the GT and the driven centrifugal gas compressor operating conditions can lead to larger bleed losses due to wider bleed valve openings. The bleed loss inevitably manifests itself in the form of higher overall heat rate of the GT and greater engine emission. It is, therefore, imperative to determine and understand the engine and process conditions that drive the GT to operate in these different modes. The ultimate objective is to operate the engine away from the inefficient modes by adjusting the driven gas compressor parameters as well as the overall station operating conditions (i.e., load sharing, control set points, etc.). This paper describes a methodology to couple the operating conditions of the gas compressor to the modes of GT bleed valve opening (and the subsequent air bleed rates) leading to identification of the operating parameters for optimal performance (i.e., best overall efficiency and minimum CO2e emission). A predictive tool is developed to quantify the overall efficiency loss as a result of the different bleed opening modes and map out the condition on the gas compressor characteristics. One year's worth of operating data taken from two different compressor stations on TransCanada Pipelines' Alberta system were used to demonstrate the methodology. The first station employs a GE-LM1600 gas turbine driving a Cooper Rolls-RFBB-30 centrifugal compressor. The second station employs a GE-LM-2500+ gas turbine driving NP PCL-800/N compressor. The analysis conclusively indicates that there are operating regions on the gas compressor maps where losses due to bleed valves are reduced and, hence, CO2 emissions are lowered, which presents an opportunity for operation optimization.
Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesis (2001)

Tumor-derived prostaglandins (PGs) have been implicated in the progression of murine and human breast cancer. Chronic treatment with a non-selective PG inhibitor indomethacin was shown in this laboratory to retard the development and metastasis of spontaneous mammary tumors in C3H/HeJ female retired breeder mice. The present study examined the role of endogenous prostaglandins in the proliferation/survival, the migratory and invasive behavior and angiogenic ability of a highly metastatic murine mammary tumor cell line, C3L5, originally derived from a C3H/HeJ spontaneous mammary tumor. This cell line was shown to express high levels of cyclooxygenase (COX) -2 mRNA and protein as detected by Northern and Western blotting as well as immunostaining. PGE(2) production by C3L5 cells was primarily owing to COX-2, since this was blocked similarly with non-selective COX inhibitor indomethacin and selective COX-2 inhibitor NS-398, but unaffected with the selective COX-1 inhibitor valeryl salicylate. C3L5 cell proliferation/survival in vitro was not influenced by PGs, since their cellularity remained unaffected in the presence of PGE(2) or NS-398 or PG-receptor (EP1/EP2) antagonist AH6809; a marginal decline was noted only at high doses of indomethacin, which was not abrogated by addition of exogenous PGE(2). Migratory and invasive abilities of C3L5 cells, as quantitated with in vitro transwell migration/invasion assays, were inhibited with indomethacin or NS-398 or AH6809 in a dose-dependent manner; the indomethacin and NS-398-mediated inhibition was partially reversed upon addition of exogenous PGE(2). An in vivo angiogenesis assay that used subcutaneous implants of growth factor-reduced matrigel inclusive of tumor cells showed a significant inhibition of blood vessel formation in these implants in animals treated with indomethacin compared with animals receiving vehicle alone. These studies show that selective and nonselective COX-2 inhibitors retarded tumor progression in this COX-2-expressing murine mammary tumor model by inhibiting tumor cell migration, invasiveness and tumor-induced angiogenesis. The inhibitory effects were not entirely PG dependent; some PG-independent effects were also noted.
Panchromatic chromophore–tetrapyrrole light-harvesting arrays constructed from Bodipy, perylene, terrylene, porphyrin, chlorin, and bacteriochlorin building blocks (2016)

Five new chromophore–tetrapyrrole arrays bearing an ethynyl linker have been synthesized to explore the effects of chromophore nature and tetrapyrrole attachment site on panchromatic spectral properties.
Handbook of Machining and Metalworking Calculations (2000)

Mathematics for Machinists and Metalworkers. Mensuration of Plane and Solid Figures. Layout Procedures for Geometric Figures. Measurement and Calculation Procedures for Machinists. Formulas and Calculations for Machining Operations. Formulas for Sheet Metal Layout and Fabrication. Gear and Sprocket Calculations. Ratchets and Cam Geometry. Bolts, Screws, and Thread Calculations. Spring Calculations - Die and Standard Types. Mechanisms, Linkage Geometry, and Calculations. Classes of Fit for Machined Parts - Calculations.
Introduction to General, Organic and Biochemistry (1976)

Matter, Energy, And Measurement. Atoms. Chemical Bonds. Chemical Reactions. Gases, Liquids, And Solids. Solutions and Colloids. Reaction Rates and Equilibrium. Acids and Bases. Nuclear Chemistry. Organic Chemistry: Alkanes. Alkenes, Alkynes, And Aromatic Compounds. Alcohols, Phenols, Ethers, And Halides. Aldehydes and Ketones. Carboxylic Acids and Esters. Amines and Amides. Carbohydrates. Lipids. Proteins. Enzymes. Bioenergetics: How the Body Converts Food to Energy. Specific Catabolic Pathways: Carbohydrate, Lipids, And Protein Metabolism. Biosynthetic Pathways. Nucleic Acids and Protein Synthesis. Chemical Communication: Neurotransmitters and Hormones. Body Fluids. Nutrition and Digestion.
Behandeling met melatonine van mensen met een verstandelijke beperking en chronische slaapproblemen (2011)

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Electrospray ionization tandem mass spectrometric study of salt cluster ions. Part 1? Investigations of alkali metal chloride and sodium salt cluster ions (2001)

Salt cluster ions of alkali metal chlorides ACl (A = Li(+), Na(+), K(+), Rb(+) and Cs(+)) and sodium salts NaB (B = I(-), HCOO(-), CH(3)COO(-), NO(2)(-), and NO(3)(-)), formed by electrospray ionization, were studied systematically by mass spectrometry. The influences on the total positive ion and negative ion currents of variation of solvent, solution concentration, desolvation temperature, solution flow-rate, capillary voltage and cone voltage were investigated. Only cone voltage was found to influence dramatically the distribution of salt cluster ions in the mass spectra observed. Under conditions of normal cone voltage of approximately 70 V, cluster ions having magic numbers of molecules are detected with high relative signal intensity. Under conditions of low cone voltage of approximately 10 V, the distribution of cluster ions detected is characterized by a relatively low average mass/charge ratio due to the presence of multiply charged cluster ions; in addition, there is a marked reduction in cluster ions having a magic number of molecules. Product ion mass spectra obtained by tandem mass spectrometry of cluster ions are characterized by a base peak having a magic number of molecules that is less than and closest to the number of molecules in the precursor ion. Structures have been proposed for some dications and some quadruply charged ions. At pH 3 and 11, the mass spectra of NaCl clusters show the presence of mixed clusters of NaCl with HCl and NaOH, respectively. The effects of ionic radius on 20 distributions of cluster ions for 10 salts were investigated; however, the fine structure of these effects is not readily discerned.
Oral Griseofulvin Remains the Treatment of Choice for Tinea Capitis in Children (2000)

Tinea capitis is one of the most common infections of children. The standard treatment is griseofulvin. Itraconazole and terbinafine have in large part replaced griseofulvin in the treatment of onychomycosis and, in addition to fluconazole and ketoconazole, are evolving treatments for tinea capitis. The purpose of this review is to compare the efficacy, safety, and cost of oral antifungal agents for tinea capitis. Small, open-label studies of itraconazole, terbinafine, and fluconazole have reported encouraging results, suggesting that these drugs may be effective alternatives to griseofulvin; however, in large controlled studies griseofulvin continues to exhibit greater or equal efficacy. Ketoconazole appears to be the least efficacious. All five drugs appear relatively safe, however, only griseofulvin has a long track record of safety, is Food and Drug Administration (FDA) approved for the treatment of tinea capitis in children, and has the least known drug interactions. Fluconazole is FDA approved for use in children more than 6 months of age, yet not for the treatment of tinea capitis. Oral griseofulvin and terbinafine tablets are the least expensive of the antifungal agents; griseofulvin suspension is, however, more expensive than fluconazole suspension. For the combined reasons of efficacy, safety, and cost, and a long track record of use, we feel oral griseofulvin is still the present treatment of choice for tinea capitis. Newer antifungals are currently under investigation, and their role in treating tinea capitis in children is still being defined.
A CMOS adaptive interference reduction system for nerve cuff recordings (2002)

This paper describes the realisation of an automatic control system for use in nerve cuff recordings. The system compensates for any impedance mismatches in the cuff by adaptively adjusting the gains of the input differential amplifiers connected to the cuff electrodes. As a result, interference pick-up during nerve recordings is greatly reduced. The gains of the variable gain amplifiers are adjusted by means of current feedback. The control chip was fabricated in 0.8μm CMOS technology, has a core area of 0.35mm2and consumes 3.5mW from ±2.5V power supplies. © 2002 Non IEEE.
Origin of Electrochemical, Structural, and Transport Properties in Nonaqueous Zinc Electrolytes (2016)

Through coupled experimental analysis and computational techniques, we uncover the origin of anodic stability for a range of nonaqueous zinc electrolytes. By examination of electrochemical, structural, and transport properties of nonaqueous zinc electrolytes with varying concentrations, it is demonstrated that the acetonitrile-Zn(TFSI)2, acetonitrile-Zn(CF3SO3)2, and propylene carbonate-Zn(TFSI)2 electrolytes can not only support highly reversible Zn deposition behavior on a Zn metal anode (≥99% of Coulombic efficiency) but also provide high anodic stability (up to ∼3.8 V vs Zn/Zn(2+)). The predicted anodic stability from DFT calculations is well in accordance with experimental results, and elucidates that the solvents play an important role in anodic stability of most electrolytes. Molecular dynamics (MD) simulations were used to understand the solvation structure (e.g., ion solvation and ionic association) and its effect on dynamics and transport properties (e.g., diffusion coefficient and ionic conductivity) of the electrolytes. The combination of these techniques provides unprecedented insight into the origin of the electrochemical, structural, and transport properties in nonaqueous zinc electrolytes.
Professional Care of GNSS Handheld with Internal Antenna: What Position Accuracy One Can Expect (2010)

In recent years, the real time GIS Market has obvious tendency towards position availability, reliability and accuracy improvement. Many users are not satisfied with standard open sky meter level and seek for (sub) foot accuracy in real-time. The key requirements which currently allow such a level are: working with multiple GNSS signals, applying differential mode with internal or external communication devices, and using high quality antenna. Such a configuration, either of Smart Antenna type with a controller, or a handheld GNSS receiver with external antenna and communication devices, will result in up to cm level (GNSS RTK) accuracy. But many GIS users are looking for improvement with not so expensive handhelds without external antenna and external communication modules (a single unit without extra accessory). 
Ashtech has developed a real time technology which allows to get wide spectrum of GIS accuracy (from meter level down to cm depending on configuration and environment) using a single GNSS handheld receiver. Such a technology allows getting meter level standalone position, sub-meter level SBAS differential position and decimeter level float RTK position against a single base or Network. For short open sky baselines receiver can ultimately provide cm level accuracy with high availability. 
The paper describes the challenges to get improved positioning with sole handheld unit and provides real life performance assessment for different operation modes and applications. As a final supplement, we describe what additional GNSS performance may be delivered when in addition a high-grade external antenna is connected to a handheld receiver.
New electrogenerated conducting poly(thiophenes) containing substituted phenyl groups (1990)

New conducting polymers have been synthesised by electropolymerisation of 3-(benzyloxyethyl)thiophenes; substitution of the phenyl ring has no direct electronic effect on the conjugated backbone but controls the spectroscopic and electrochemical properties of the polymer by means of substituent interactions.