gebhart/patrepeval huggingface dataset:
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation (2006)

Thiazolidinedione (TZD), a ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), exerts anti-inflammatory effects independently of the insulin-sensitizing effect. In the present study, we tested the hypothesis that TZD prevents the progression of diabetic nephropathy by modulating the inflammatory process. Five-week-old Sprague-Dawley rats were divided into three groups: 1) nondiabetic control rats (non-DM), 2) diabetic rats (DM), and 3) diabetic rats treated with pioglitazone (DM+pio). Diabetes was induced by injection with streptozotocin (STZ). The DM+pio group received 0.0002% pioglitazone mixed in chow for 8 wk after induction of diabetes. Blood glucose and HbA1c were elevated in diabetic rats but did not change by treatment with pioglitazone. Pioglitazone reduced urinary albumin excretion and glomerular hypertrophy, suppressed the expression of transforming growth factor (TGF)-beta, type IV collagen, and ICAM-1, and infiltration of macrophages in the kidneys of diabetic rats. Furthermore, renal NF-kappaB activity was increased in diabetic rats and reduced by pioglitazone. PPAR-gamma was expressed in glomerular endothelial cells in the diabetic kidney and in cultured glomerular endothelial cells. High-glucose conditions increased the expression of ICAM-1 and the activation of NF-kappaB in cultured glomerular endothelial cells. These changes were reduced by pioglitazone, ciglitazone, and pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB. However, pioglitazone did not show the changes in the presence of PPAR-gamma antagonist GW9662. Our results suggest that the preventive effects of pioglitazone may be mediated by its anti-inflammatory actions, including inhibition of NF-kappaB activation, ICAM-1 expression, and macrophage infiltration in the diabetic kidney.
The PowerPC performance modeling methodology (1994)

article The PowerPC performance modeling methodology Author: Ali Poursepanj IBM Somerset Design Center, Austin, TX IBM Somerset Design Center, Austin, TXView Profile Authors Info & Claims Communications of the ACMVolume 37Issue 6June 1994 pp 47–55https://doi.org/10.1145/175208.175214Published:01 June 1994Publication History 33citation462DownloadsMetricsTotal Citations33Total Downloads462Last 12 Months10Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Enhancement of Liquid Flow Through a Porous Medium by Ultrasonic Radiation (1999)

Summary A new method to enhance the oil production rate is irradiation of the near-wellbore region by an ultrasonic source. The limited success for the application of ultrasound in well stimulation to date, however, is due to the lack of understanding of the physical mechanisms between an acoustic wave field and a porous medium. In this paper the mechanism in which ultrasonic radiation deforms the walls of the pores in the shape of traveling transversal waves is studied. A quantitative description of the mechanism indicates that these waves induce a net flow of the liquid inside the pores, identical to peristaltic transport. Numerical calculations show a damping effect of liquid compressibility and a strong influence of pore wall hardness and power output on the net flow rate induced. The occurrence of a flow induced by ultrasound has been confirmed by laboratory experiments. In these experiments a water velocity of almost 1 cm/s through a rubber capillary of 0.15 mm radius could be induced by an ultrasonic source of frequency of 20 kHz. By a comparison between the trends observed in the experiments and the theoretically predicted trends, the role of the peristaltic transport mechanism in acoustic well stimulation is discussed.
Essential Oils as Fumigants for Bed Bugs (Hemiptera: Cimicidae) (2015)

Certain plant-derived essential oils are classified as ‘minimum risk' pesticides that require no registration with the Environmental Protection Agency and, therefore, have become attractive in formulations of pest-control products. In Petri dish assays, fumigation of a pyrethroid-susceptible strain of bed bugs, Cimex lectularius L. (Hemiptera: Cimicidae), with various essential oils results in mortality that approaches or equals 100% after 5 d. However, when bed bugs were exposed to the same essential oils in sealed, commercial trash bags for 5 d, only rosemary oil killed greater than 99% of the bed bugs. These results are compared with a commercial product that contains cold-pressed neem oil that killed 100% of the exposed bed bugs in both the Petri dish and trash bag studies.
Strategies for improving physician documentation in the emergency department: a systematic review (2018)

Promising approaches to improving physician documentation in emergency department settings include audit/feedback, reminders, templates, and multi-pronged education interventions. Future research should focus on exploring the impact of implementing these interventions in EDs with and without emergency medical record systems (EMRs), and investigating the potential of emerging technologies, including EMR-based machine-learning, to promote improvements in the quality of ED documentation.
Detection and tracking of groups in crowd (2013)

We propose a method to detect and track interacting people by employing a framework based on a Social Force Model (SFM). The method embeds plausible human behaviors to predict interactions in a crowd by iteratively minimizing the error between predictions and measurements. We model people approaching a group and restrict the group formation based on the relative velocity of candidate group members. The detected groups are then tracked by linking their interaction centers over time using a buffered graph-based tracker. We show how the proposed framework outperforms existing group localization techniques on three publicly available datasets, with improvements of up to 13% on group detection.
A novel Omp25-binding peptide screened by phage display can inhibit Brucella abortus 2308 infection in vitro and in vivo (2014)

Brucellosis is a globally distributed zoonotic disease affecting animals and humans, and current antibiotic and vaccine strategies are not optimal. The surface-exposed protein Omp25 is involved in Brucella virulence and plays an important role in Brucella pathogenesis during infection, suggesting that Omp25 could be a useful target for selecting potential therapeutic molecules to inhibit Brucella pathogenesis. In this study, we identified, we believe for the first time, peptides that bind specifically to the Omp25 protein of pathogens, using a phage panning technique, After four rounds of panning, 42 plaques of eluted phages were subjected to pyrosequencing. Four phage clones that bound better than the other clones were selected following confirmation by ELISA and affinity constant determination. The peptides selected could significantly inhibit Brucella abortus 2308 (S2308) internalization and intracellular growth in RAW264.7 macrophages, and significantly induce secretion of TNF-α and IL-12 in peptide- and S2308-treated cells. Any observed peptide (OP11, OP27, OP35 or OP40) could significantly inhibit S2308 infection in BALB/c mice. Moreover, the peptide OP11 was the best candidate peptide for inhibiting S2308 infection in vitro and in vivo. These results suggest that peptide OP11 has potential for exploitation as a peptide drug in resisting S2308 infection.
Parental transmission and D18S37 allele sharing in bipolar affective disorder (1997)

We combined the five chromosome 18 bipolar affective disorder data sets provided by GAW10, totaling 185 families with 3,394 individuals, and performed analysis of differential parental transmission and chromosome 18 marker allele sharing in families with transmission through fathers vs those through mothers. Results indicated a significant excess of maternal transmission of bipolar disorder. All pedigrees were then broken into nuclear families and affected sib-pair linkage analyses performed on the marker, D18S37. There was significant linkage in the data overall, as well as in each subgroup of paternal, maternal and unknown parental transmission nuclear families. There were no significant differences in identical-by-descent (IBD) scores among the three transmission subgroups. These findings support an excess of maternal transmission, and linkage between bipolar disorder and marker D18S37. However, our results do not support the previous suggestion that there are differences in chromosome 18 marker allele sharing depending on the transmitting parent. © 1997 Wiley-Liss, Inc.
A coordinated multi-agent reinforcement learning approach to multi-level cache co-partitioning (2017)

The widening gap between the processor and memory performance has led to the inclusion of multiple levels of caches in the modern multi-core systems. Processors with simultaneous multithreading (SMT) support multiple hardware threads on the same physical core, which results in shared private caches. Any inefficiency in the cache hierarchy can negatively impact the system performance and motivates the need to perform a co-optimization of multiple cache levels by trading off individual application throughput for better system throughput and energy-delay-product (EDP). We propose a novel coordinated multiagent reinforcement learning technique for performing Dynamic Cache Co-partitioning, called Machine Learned Caches (MLC). MLC has low implementation overhead and does not require any special hardware data profilers. We have validated our proposal with 15 8-core workloads created using Spec2006 benchmarks and found it to be an effective co-partitioning technique. MLC exhibited system throughput and EDP improvements of up to 14% (gmean:9.35%) and 19.2% (gmean: 13.5%) respectively. We believe this is the first attempt at addressing the problem of multi-level cache co-partitioning.
Dosimetric evaluation of Plastic Water Diagnostic Therapy (2008)

High-precision radiotherapy planning and quality assurance require accurate dosimetric and geometric phantom measurements. Phantom design requires materials with mechanical strength and resilience, and dosimetric properties close to those of water over diagnostic and therapeutic ranges. Plastic Water Diagnostic Therapy (PWDT: CIRS, Norfolk, VA) is a phantom material designed for water equivalence in photon beams from 0.04 MeV to 100 MeV; the material has also good mechanical properties. The present article reports the results of computed tomography (CT) imaging and dosimetric studies of PWDT to evaluate the suitability of the material in CT and therapy energy ranges. We characterized the water equivalence of PWDT in a series of experiments in which the basic dosimetric properties of the material were determined for photon energies of 80 kVp, 100 kVp, 250 kVp, 4 MV, 6 MV, 10 MV, and 18 MV. Measured properties included the buildup and percentage depth dose curves for several field sizes, and relative dose factors as a function of field size. In addition, the PWDT phantom underwent CT imaging at beam qualities ranging from 80 kVp to 140 kVp to determine the water equivalence of the phantom in the diagnostic energy range. The dosimetric quantities measured with PWDT agreed within 1.5% of those determined in water and Solid Water (Gammex rmi, Middleton, WI). Computed tomography imaging of the phantom was found to generate Hounsfield numbers within 0.8% of those generated using water. The results suggest that PWDT material is suitable both for regular radiotherapy quality assurance measurements and for intensity-modulated radiation therapy (IMRT) verification work. Sample IMRT verification results are presented.
ALPS- A potential new automated lumber processing system (1984)

Apres un examen tomographique des grumes, un ordinateur determine la strategie optimale du sciage et controle le processus. Une analyse d'image video des planches permet de determiner le type et l'emplacement des defauts de surface. Un plan de decoupe optimale des planches est calcule par l'ordinateur, la decoupe etant effectuee par un laser dirige par l'ordinateur. Les pieces sont classees par tailles automatiquement et les residus utilises comme combustible
Event-Based Communications for Equipment Supervisory Control (2006)

Event-based approaches are becoming more and more popular for building large scale distributed systems and applications, especially in the Internet environment. In this paper, the concept and techniques of event-based communications are first discussed. A hybrid approach of event-based communications for real-time manufacturing supervisory control is then proposed together with an "event-based communication agent" (ECA) framework to provide extendable and reliable communications, as well as efficient development method in multi-OS, multiple types of network protocol environment. A case study involving an industrial implementation for a large-scale distributed supervisory control system based on this approach is then discussed.
MuVR: A Multi-User Virtual Reality platform (2014)

Consumer adoption of virtual reality technology has historically been held back by poor accessibility, the lack of intuitive multi-user capabilities, dependence on external infrastructure for rendering and tracking, and the amount of time and effort required to enter virtual reality systems. This poster presents the current status of our work creating MuVR, a Multi-User Virtual Reality platform that seeks to overcome these hindrances. The MuVR project comprises four main goals: scalable and easy to use multi-user capabilities, portable and self-contained hardware, a rapidly deployable system, and ready accessibility to others. We provide a description of the platform we developed to address these goals and discuss potential directions for future work.
Algorithm of Signal Recognition for Railway Embedded Control Devices (2018)

In this paper proposed algorithm solves the problem of the trains passing through the red light and thus decrease the dangerous level of railway transportation process. System structure, based on the embedded electronic device with artificial intelligence, is proposed and described in the paper. To gain the better results, the research was divided in four tasks: railway traffic light recognition, railway traffic light red signal recognition, decision making to start braking and finally generate appropriate signal to locomotive's transmission and braking control system.
Transfectant CHO cells expressing O<sup>6</sup>-alkylguanine-DNA-alkyltransferase display increased resistance to DNA damage other than O<sup>6</sup>-guanine alkylation (1987)

BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea, Carmustine] is a nitrosourea that crosslinks DNA and is useful in cancer chemotherapy. Tumor cells resistant to BCNU produce high levels of O6-alkylguanine-DNA-alkyltransferase (AT), a protein that removes the O6-guanine adduct formed by BCNU prior to crosslinking. By the transfection of a human cosmid library into the Chinese hamster ovary cell line AA8, several transgenic cell lines which express the AT gene have been constructed. These 'BR' cells were isolated on the basis of their resistance to G-418 and BCNU. Like human mer+ strains, BR cells (relative to the parental AA8 cells) are approximately 500 times more resistant to the cytotoxic effects of 80 microM BCNU. Treatment with exogenous O6-methylguanine (O6MG), which depletes cellular AT, abolishes their BCNU resistance. Also consistent with the mer+ phenotype, BR cells are resistant to the mutagenic and killing activity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Treatment with exogenous O6MG, while reversing the resistance to MNNG mutation, does not reverse the resistance to MNNG killing. Unexpectedly, BR cells also exhibit resistance to killing by dimethylsulfate (DMS). The BR cells are not, however, detectably resistant to UV light. These results suggest that AT activity in mammalian cells is closely linked to the activity of other DNA repair pathways.
Knowledge, Attitude and Practice of Blood Donation among University Students in Kashmir valley (2020)

Background: Young, healthy and physically fit students can play a vital role in blood donation. Youth constitute a good proportion of the Kashmiri population so it is very important that we encourage, inspire and motivate them to donate blood on regular basis voluntarily rather than on need basis. The present study was conducted in Kashmir valley to assess the University student’s awareness and attitude towards blood donation. 
Material and Methods: In this cross sectional study, 800 University students selected at random from various Universities of Kashmir valley using stratified random sampling technique were evaluated using a well-designed validated questionnaire. The information collected on socio-demographic variables, knowledge and attitude of students towards blood donation was assessed using appropriate statistical tools. 
Results: A total of 800 students, 50% boys and 50% girls were evaluated in present study. The results of our study showed that only (5.5%) of total respondents had a history of blood donation and out of these respondents 90% respondents donate only once. The study reveals that the most mentioned reasons behind not donating blood were; not being asked to donate blood (43.5%); inconsideration of donation (29.5%) and fear of drawing blood (27.0%). The study also revealed that 53.5% students had adequate knowledge regarding blood donation and 93.5% students understudy showed positive attitude towards blood donation. The male students were more knowledgeable and showed more interest in donating blood than female respondents. 
Conclusion: The current study showed that inadequate knowledge was prevalent among substantial proportion of University students in Kashmir valley, and there was a significant disparity in Knowledge between male and female students. The study further, showed despite the positive attitude of students towards blood donation, only 5.5% students had history of blood donation. It was concluded that blood donation camps and education programs are necessary to motivate youth and increase awareness towards voluntary blood donation rather than donating blood on need basis.
ChemInform Abstract: Chiral Synthons by Enantioselective Hydrolysis of meso‐Diesters with Pig Liver Esterase: Substrate‐Stereoselectivity Relationships. (1987)

Abstract Various meso‐diesters undergo efficient asymmetric hydrolysis with PLE (pig liver esterase) as outhined in the reaction scheme.
Enhancement by Recombinant Human Bone Morphogenetic Protein-2 of Bone Formation by Means of Porous Hydroxyapatite in Mandibular Bone Defects (1999)

Hydroxyapatite is osteoconductive and can maintain an original biocompatible form. It is useful, in the reconstruction of bone defects, to enhance the osteoconduction of hydroxyapatite with an osteogenic protein. The aim of this study was to evaluate the bone formation in surgically created defects of rabbit mandibles by a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2), with porous hydroxyapatite and atelopeptide type I collagen used as the carrier for rhBMP-2. A 10-microg rhBMP-2-implanted group (n = 15) and a control group (n = 15), in which only atelopeptide type I collagen and porous hydroxyapatite were implanted, were histologically examined 3, 7, and 21 days after implantation. The alkaline phosphatase activity was also quantitatively analyzed. No new bone formation was observed in either the tested or the control group after 3 days. At 7 days, immature bone tissue was observed in some pores of the rhBMP-2implanted group, while in the control group, immature mesenchymal cells were observed. At 21 days, trabecular bone lined some pore walls. In the central portion, the bone marrow, including angioid tissue, was observed. New trabecular bone formation was observed on portions of the external surface of the hydroxyapatite disk. On the other hand, the control group showed infiltration of immature mesenchymal cells into some pores. Marginal bone formation was found in the pores close to the surface of the disk which opposed mandibular bone. The control group showed a slow, small increase in alkaline phosphatase activity in this study, while the experimental group showed a marked increase at 21 days. This increase was significantly higher in the tested group than in the control group at both 7 and 21 days. The findings indicate that rhBMP-2 accelerated bone formation by osteoconduction from porous hydroxyapatite. The combination of rhBMP-2, atelopeptide type I collagen, and porous hydroxyapatite is suggested to be advantageous for clinical application in reconstructing mandibular bone defects.
Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215 (2004)

The tumor suppressor p53 is important in the decision to either arrest cell cycle progression or induce apoptosis in response to a variety of stimuli. p53 posttranslational modifications and association with other proteins have been implicated in the regulation of its stability and transactivation activity. Here we show that p53 is phosphorylated by the mitotic kinase Aurora-A at serine 215. Unlike most identified phosphorylation sites of p53 that positively associate with p53 function (Brooks, C. L., and Gu, W. (2003) Curr. Opin. Cell Biol. 15, 164-171), the phosphorylation of p53 by Aurora-A at Ser-215 abrogates p53 DNA binding and transactivation activity. Downstream target genes of p53, such as p21Cip/WAF1 and PTEN, were inhibited by Aurora-A in a Ser-215 phosphorylation-dependent manner (i.e. phosphomimic p53-S215D lost and non-phosphorylatable p53-S215A retained normal p53 function). As a result, Aurora-A overrides the apoptosis and cell cycle arrest induced by cisplatin and gamma-irradiation, respectively. However, the effect of Aurora-A on p53 DNA binding and transactivation activity was not affected by phosphorylation of Ser-315, a recently identified Aurora-A phosphorylation site of p53 (Katayama, H., Sasai, K., Kawai, H., Yuan, Z. M., Bondaruk, J., Suzuki, F., Fujii, S., Arlinghaus, R. B., Czerniak, B. A., and Sen, S. (2004) Nat. Genet. 36, 55-62). Our data indicate that phosphorylation of p53 at Ser-215 by Aurora-A is a major mechanism to inactivate p53 and can provide a molecular insight for Aurora-A function.