gebhart/patrepeval huggingface dataset:
TCP Mobility Option with Identifiers (2017)

This document specifies the TCP Seamless Mobility Option (TCP-SMO)
with variable length identifiers. TCP-SMO allows mobility with session
continuity, when either of the TCP endpoint change its IP address.
This is being done securely and without any additional round trips
during mobility event.
Embedded Non-destructive Evaluation for Structural Health Monitoring, Damage Detection, and Failure Prevention (2005)

In this paper we review the state of the art in an emerging new technology: embedded ultrasonic non-destructive evaluation (NDE). Embedded ultrasonic NDE permits active structural health monitoring, i.e. the on-demand interrogation of the structure to determine its current state of structural health. The enabling element of embedded ultrasonic NDE is the piezoelectric wafer active sensor (PWAS). We begin by reviewing the guided wave theory in plate, tube, and shell structures, with special attention to Lamb waves. The mechanisms of Lamb wave excitation and detection with embeddable PWAS transducers is presented. It is shown analytically and verified experimentally that Lamb wave mode tuning can be achieved by the judicious combination of PWAS dimensions, frequency value, and Lamb mode characteristics. Subsequently, we address in turn the use of pitch-catch, pulse-echo, and phased array ultrasonic methods for Lambwave damage detection. In each case, the conventional ultrasonic NDE results are contrasted with embedded NDE results. Detection of cracks, disbonds, delaminations, and diffuse damage in metallic and composite structures are exemplified. Other techniques, such as the time reversal method and the migration technique, are also presented. The paper ends with conclusions and suggestions for further work.
ChemInform Abstract: Furo(3,4‐d)pyrimidine‐2,4‐dione Derivatives with Antihypertensive Activity. Analogues of Thienopyrimidine‐2,4‐diones. (1990)

Abstract The potency of the most active title compounds (III) is similar to that of the thiophene isosters.
Self-stratification of amphiphilic Janus particles at coating surfaces (2020)

Durable hydrophobic coatings are created by adding amphiphilic Janus particles to binder polymers through the unique self-stratification behaviours, which offer a novel and cost-effective solution to challenges in waterborne emulsion coatings.
Pseudoinfectious Venezuelan Equine Encephalitis Virus: a New Means of Alphavirus Attenuation (2012)

Venezuelan equine encephalitis virus (VEEV) is a reemerging virus that causes a severe and often fatal disease in equids and humans. In spite of a continuous public health threat, to date, no vaccines or antiviral drugs have been developed for human use. Experimental vaccines demonstrate either poor efficiency or severe adverse effects. In this study, we developed a new strategy of alphavirus modification aimed at making these viruses capable of replication and efficient induction of the immune response without causing a progressive infection, which might lead to disease development. To achieve this, we developed a pseudoinfectious virus (PIV) version of VEEV. VEE PIV mimics natural viral infection in that it efficiently replicates its genome, expresses all of the viral structural proteins, and releases viral particles at levels similar to those found in wild-type VEEV-infected cells. However, the mutations introduced into the capsid protein make this protein almost incapable of packaging the PIV genome, and most of the released virions lack genetic material and do not produce a spreading infection. Thus, VEE PIV mimics viral infection in terms of antigen production but is safer due to its inability to incorporate the viral genome into released virions. These genome-free virions are referred to as virus-like particles (VLPs). Importantly, the capsid-specific mutations introduced make the PIV a very strong inducer of the innate immune response and add self-adjuvant characteristics to the designed virus. This unique strategy of virus modification can be applied for vaccine development against other alphaviruses.
Integration of low permittivity dielectric in Aldual damascene architecture for low parasiticon-chip interconnect applications (1998)

A low dielectric constant (low-κ) material has been successfully integrated in an Al dual damascene interconnect architecture where the low-κ dielectric (κ < 3) was used as the intra/inter level dielectric (ILD). In addition to a reduction in intra-level and inter-level capacitance, low via resistance, excellent electrical isolation and good reliability characteristics were observed.
Filter design and calibration for fingernail sensors to measure fingertip forces and finger posture (2003)

When the human fingertip is pressed against a surface or bent, the hemodynamic state of the fingertip is altered due to mechanical interactions between the fingernail and bone. Normal force, shear force, and finger extension/flexion all result in different patterns of blood volume beneath the fingernail. This phenomenon has been exploited in order to detect finger forces and finger posture by creating a photoplethysmograph "fingernail sensor," which measures the two-dimensional pattern of blood volume beneath the fingernail. In this paper, a filter is designed to predict the normal force, lateral shear force, longitudinal shear force, and bending angle based on readings from the fingernail sensor. Linear, polynomial and neural network models are proposed as candidates for the predictor framework. A method is developed to uniformly calibrate the predictor for each user. Calibration experiments are performed to train and validate the predictor for seven human subjects. Results indicate that a simple linear model performs best, predicting shear forces with an average of 0.5 N r.m.s. error and normal force with an average of 1.0 N r.m.s. error.
Accelerating Boolean satisfiability with configurable hardware (2002)

This paper describes and evaluates methods for implementing formula-specific Boolean satisfiability (SAT) solver circuits in configurable hardware. Starting from a general template design, our approach automatically generates VHDL for a circuit that is specific to the particular Boolean formula being solved. Such an approach tightly customizes the circuit to a particular problem instance. Thus, it represents an ideal use for dynamically-reconfigurable hardware, since it would be impractical to fabricate an ASIC for each Boolean formula being solved. Our approach also takes advantage of direct gate mappings and large degrees of fine-grained parallelism in the algorithm's Boolean logic evaluations. We compile our designs to two hardware targets: an IKOS logic emulation system, and Digital SRC's Pamette configurable computing board. Performance evaluations on the DIMACS SAT benchmark suite indicate that our approach offers speedups from 17X to more than a thousand times. Overall, this SAT solver demonstrates promising performance speedups on an important and complex problem with extensive applications in the CAD and AI communities.
Correction: Corrigendum: Towards ultrasensitive malaria diagnosis using surface enhanced Raman spectroscopy (2017)

Scientific Reports 6: Article number: 20177; published online: 09 February 2016; updated: 23 March 2017 In this Article, Yaw Aniweh and Peter Preiser are incorrectly listed as being affiliated with the ‘School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457’.
Molecular Cloning, Stable Expression and Desensitization of the Human Dopamine D1B / D5 Receptor (1993)

The sub-family of dopamine D1-like receptors is now known to be comprised of at least two members: the originally cloned D1 receptor (herein referred to as the D1a receptor) and a related receptor referred to as the D1b, D1β or D5 dopamine receptor (herein referred to as the D1b/D5 receptor). Here, we characterize the D1b/D5 receptor expressed transiently in COS-7 cells and permanently in Ltk− cells.Transiently expressed human D1b/D5 receptors bind the D1 specific ligand [125I]SCH 23982 saturably and with high affinity (KD = 500 pM). Competition for [125I]SCH 23982 binding to rat D1b/D5 and human D1a and D1b/D5 receptors supports the contention that the two D1b/D5 receptors are species homologues. Furthermore, in COS-7 cells, as previously observed, dopamine competes for the binding of [125I]SCH 23982 to human D1b/D5 receptors with a higher affinity than that seen at the human D1a receptor. These results are similar to those seen in Ltk− cells permanently transfected with the human D1b/D5 receptor. In these cells, dopamine competition for [125I]SCH 23982 binding is complex, sensitive to guanine nucleotides and of a higher affinity than that observed for dopamine binding to the human D1a receptor expressed in these same cells. In both D1a and D1b/D5 expressing Ltk− cells, dopamine stimulates adenylyl cyclase with an EC50 of = 200 nM. Furthermore, preincubation of Ltk− cells expressing the D1a and D1b/D5 receptors with dopamine results in desensitization of the response of adenylyl cyclase to subsequent agonist stimulation.
VUV synchrotron radiation: a new activation technique for tandem mass spectrometry (2012)

A novel experimental technique for tandem mass spectrometry and ion spectroscopy of electrosprayed ions using vacuum-ultraviolet (VUV) synchrotron radiation is presented. Photon activation of trapped precursor ions has been performed by coupling a commercial linear quadrupole ion trap (Thermo scientific LTQ XL), equipped with the electrosprayed ions source, to the DESIRS beamline at the SOLEIL synchrotron radiation facility. The obtained results include, for the first time on biopolymers, photodetachment spectroscopy using monochromated synchrotron radiation of multi-charged anions and the single photon ionization of large charge-selected polycations. The high efficiency and signal-to-noise ratio achieved by the present set-up open up possibilities of using synchrotron light as a new controllable activation method in tandem mass spectrometry of biopolymers and VUV-photon spectroscopy of large biological ions.
Photo-Enhanced Luminescence in Bio-conjugated Quantum Dots for Ovarian Cancer Biomarkers (2005)

Luminescent semiconductor quantum dots (QDs) can be readily conjugated with biomolecules and serve as sensitive probes for early detection of the cancer cells, specifically for ovarian cancer, which represents the most lethal gynecologic malignancy. We report on the luminescence characterization of the bio-conjugated QDs with CA125 antigen using linkage molecules. Kinetic curves of the bio-conjugated 655nm QD luminescence show both photo-enhancement and photo-degradation. Photo-enhancement is measured at various laser power densities, temperatures and laser wavelengths. The mechanism of the PL enhancement is discussed.
Wavelet method for CT colonography computer-aided polyp detectiona) (2008)

Computed tomographic colonography (CTC) computer aided detection (CAD) is a new method to detect colon polyps. Colonic polyps are abnormal growths that may become cancerous. Detection and removal of colonic polyps, particularly larger ones, has been shown to reduce the incidence of colorectal cancer. While high sensitivities and low false positive rates are consistently achieved for the detection of polyps sized 1 cm or larger, lower sensitivities and higher false positive rates occur when the goal of CAD is to identify "medium"-sized polyps, 6-9 mm in diameter. Such medium-sized polyps may be important for clinical patient management. We have developed a wavelet-based postprocessor to reduce false positives for this polyp size range. We applied the wavelet-based postprocessor to CTC CAD findings from 44 patients in whom 45 polyps with sizes of 6-9 mm were found at segmentally unblinded optical colonoscopy and visible on retrospective review of the CT colonography images. Prior to the application of the wavelet-based postprocessor, the CTC CAD system detected 33 of the polyps (sensitivity 73.33%) with 12.4 false positives per patient, a sensitivity comparable to that of expert radiologists. Fourfold cross validation with 5000 bootstraps showed that the wavelet-based postprocessor could reduce the false positives by 56.61% (p <0.001), to 5.38 per patient (95% confidence interval [4.41, 6.34]), without significant sensitivity degradation (32/45, 71.11%, 95% confidence interval [66.39%, 75.74%], p=0.1713). We conclude that this wavelet-based postprocessor can substantially reduce the false positive rate of our CTC CAD for this important polyp size range.
Optical injection locking of X-band FET oscillator using coherent mixing of GaAlAs lasers (1983)

A 9.6 GHz GaAs FET oscillator was optically injection locked at the fundamental frequency. The locking bandwidth was 1.6 MHz. The optical injecting signal was generated using coherent mixing of two semiconductor lasers injection locked by different FM sidebands of another laser.
Rapid Methods for Frying Oil Quality Determination: Evaluation with Respect to Legislation Criteria (2016)

Abstract This work focuses on the evaluation of commercially available rapid methods for determining frying oil quality. Five rapid methods differing in principle were selected: FOM320 (Ebro), PCT120 (3M), LRSM (3M), Fritest (Merck) and Viscofrit (Viscofrit). The performance of the methods was examined by use of 184 oil samples produced by controlled frying experiments. Twelve series of frying experiments (45 batches each) were performed in which the oil type (palm, sunflower and olive) and the food type (potatoes, zucchini and minced beef meat) varied. Control thermal oxidation experiments with the same oil types were also performed. Results of the rapid methods were compared to results of analytical methods determining legislation criteria. Namely, the total polar compounds and total polymer compounds were determined using High Pressure Size Exclusion Chromatography with and without prior separation of the polar fraction. Furthermore, determination of the free fatty acid concentration, acidity, viscosity and level of oxidation of the oils using UV spectroscopy were carried out. Principal component analysis and linear regression analysis were used in order to assess the obtained results. Comparison of the results of the rapid methods with the analytical ones showed differences in most examined cases. For many of the examined rapid methods the agreement of the results versus those of analytical methods depended on the food‐oil combination used in the frying experiments.
Synthesis of Graphene Films on Copper Foils by Chemical Vapor Deposition (2016)

Over the past decade, graphene has advanced rapidly as one of the most promising materials changing human life. Development of production-worthy synthetic methodologies for the preparation of various types of graphene forms the basis for its investigation and applications. Graphene can be used in the forms of either microflake powders or large-area thin films. Graphene powders are prepared by the exfoliation of graphite or the reduction of graphene oxide, while graphene films are prepared predominantly by chemical vapor deposition (CVD) on a variety of substrates. Both metal and dielectric substrates have been explored; while dielectric substrates are preferred over any other substrate, much higher quality graphene large-area films have been grown on metal substrates such as Cu. The focus here is on the progress of graphene synthesis on Cu foils by CVD, including various CVD techniques, graphene growth mechanisms and kinetics, strategies for synthesizing large-area graphene single crystals, graphene transfer techniques, and, finally, challenges and prospects are discussed.
Efficient SPectrAl Neighborhood blocking for entity resolution (2011)

In many telecom and web applications, there is a need to identify whether data objects in the same source or different sources represent the same entity in the real-world. This problem arises for subscribers in multiple services, customers in supply chain management, and users in social networks when there lacks a unique identifier across multiple data sources to represent a real-world entity. Entity resolution is to identify and discover objects in the data sets that refer to the same entity in the real world. We investigate the entity resolution problem for large data sets where efficient and scalable solutions are needed. We propose a novel unsupervised blocking algorithm, namely SPectrAl Neighborhood (SPAN), which constructs a fast bipartition tree for the records based on spectral clustering such that real entities can be identified accurately by neighborhood records in the tree. There are two major novel aspects in our approach: 1)We develop a fast algorithm that performs spectral clustering without computing pairwise similarities explicitly, which dramatically improves the scalability of the standard spectral clustering algorithm; 2) We utilize a stopping criterion specified by Newman-Girvan modularity in the bipartition process. Our experimental results with both synthetic and real-world data demonstrate that SPAN is robust and outperforms other blocking algorithms in terms of accuracy while it is efficient and scalable to deal with large data sets.
Population pharmacokinetics of ceftolozane/tazobactam in healthy volunteers, subjects with varying degrees of renal function and patients with bacterial infections (2014)

Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and β-lactamase inhibitor in clinical development for treatment of complicated urinary tract (cUTI) and intra-abdominal (cIAI) infections and nosocomial pneumonia. The population pharmacokinetics of ceftolozane/tazobactam were characterized in healthy volunteers, subjects with varying degrees of renal function, and patients with cIAI or cUTI. Serum concentration data from 376 adults who received ceftolozane/tazobactam in doses ranging from 500 to 3000 mg were analyzed to identify factors contributing to the pharmacokinetic variability. Ceftolozane/tazobactam pharmacokinetics were well described by a linear two-compartment model with first-order elimination and moderate between-subject variability in both clearance and volume of distribution (Vc). For both ceftolozane and tazobactam, clearance was highly correlated with renal function with creatinine clearance influencing exposure, and infection influencing Vc. Body weight was an additional covariate affecting the Vc of ceftolozane. Other covariates tested, such as age, body weight, sex, ethnicity, and presence of infection, had no clinically relevant effects on exposure. The final pharmacokinetic models adequately described the plasma concentrations of ceftolozane and tazobactam and form the basis for further modeling and simulation including evaluation of probability of target attainment in a diverse population with varying demographics, degrees of renal function, and infection status.
An adrenal β-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo (2009)

Aldosterone produces a multitude of effects in vivo, including promotion of postmyocardial infarction adverse cardiac remodeling and heart failure progression. It is produced and secreted by the adrenocortical zona glomerulosa (AZG) cells after angiotensin II (AngII) activation of AngII type 1 receptors (AT(1)Rs). Until now, the general consensus for AngII signaling to aldosterone production has been that it proceeds via activation of G(q/11)-proteins, to which the AT(1)R normally couples. Here, we describe a novel signaling pathway underlying this AT(1)R-dependent aldosterone production mediated by beta-arrestin-1 (betaarr1), a universal heptahelical receptor adapter/scaffolding protein. This pathway results in sustained ERK activation and subsequent up-regulation of steroidogenic acute regulatory protein, a steroid transport protein regulating aldosterone biosynthesis in AZG cells. Also, this betaarr1-mediated pathway appears capable of promoting aldosterone turnover independently of G protein activation, because treatment of AZG cells with SII, an AngII analog that induces betaarr, but not G protein coupling to the AT(1)R, recapitulates the effects of AngII on aldosterone production and secretion. In vivo, increased adrenal betaarr1 activity, by means of adrenal-targeted adenoviral-mediated gene delivery of a betaarr1 transgene, resulted in a marked elevation of circulating aldosterone levels in otherwise normal animals, suggesting that this adrenocortical betaarr1-mediated signaling pathway is operative, and promotes aldosterone production and secretion in vivo, as well. Thus, inhibition of adrenal betaarr1 activity on AT(1)Rs might be of therapeutic value in pathological conditions characterized and aggravated by hyperaldosteronism.
Imaging optically induced neural activity in the brain (2010)

Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS. This study presents our first attempt to translate INS to in vivo stimulation of the CNS and to image the related response. The results from this study show that INS generates intrinsic optical signals of similar magnitude and shape associated with well characterized mechanical stimuli. The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural prosthetics.
Temporal-Code to Rate-Code Conversion by Neuronal Phase-Locked Loops (1998)

Peripheral sensory activity follows the temporal structure of input signals. Central sensory processing uses also rate coding, and motor outputs appear to be primarily encoded by rate. I propose here a simple, efficient structure, converting temporal coding to rate coding by neuronal phase-locked loops (PLL). The simplest form of a PLL includes a phase detector (that is, a neuronal-plausible version of an ideal coincidence detector) and a controllable local oscillator that are connected in a negative feedback loop. The phase detector compares the firing times of the local oscillator and the input and provides an output whose firing rate is monotonically related to the time difference. The output rate is fed back to the local oscillator and forces it to phase-lock to the input. Every temporal interval at the input is associated with a specific pair of output rate and time difference values; the higher the output rate, the further the local oscillator is driven from its intrinsic frequency. Sequences of input intervals, which by definition encode input information, are thus represented by sequences of firing rates at the PLL's output. The most plausible implementation of PLL circuits is by thalamocortical loops in which populations of thalamic "relay" neurons function as phase detectors that compare the timings of cortical oscillators and sensory signals. The output in this case is encoded by the thalamic population rate. This article presents and analyzes the algorithmic and the implementation levels of the proposed PLL model and describes the implementation of the PLL model to the primate tactile system.