gebhart/patrepeval huggingface dataset:
Individuals (2010)

Two greyhounds, in running down the same hare, have sometimes the appearance of acting in some sort of concert … This, however, is not the effect of any contract, but of the accidental concurrence of their passions in the same object at that particular time. Nobody ever saw a dog make a fair and deliberate exchange of one bone for another with another dog … But man has almost constant occasion for the help of his brethren, and it is in vain for him to expect it from their benevolence only. He will be more likely to prevail if he can interest their self-love in his favour, and shew them that it is for their own advantage to do for him what he requires of them. Whoever offers to another a bargain of any kind, proposes to do this. Give me that which I want, and you shall have this which you want, is the meaning of every such offer; and it is in this manner that we obtain from one another the far greater part of those good offices which we stand in need of.Adam Smith, Wealth of Nations (1776)
Asymmetric Hydrogenation of Ketones Using a Ruthenium(II) Catalyst Containing BINOL-Derived Monodonor Phosphorus-Donor Ligands (2004)

[structure: see text] A series of ruthenium(II) complexes containing BINOL-based monodonor phosphorus ligands have been prepared and applied to the asymmetric catalysis of the hydrogenation of aryl/alkyl ketones. The best ligands for this application are those which contain an aromatic groups with either a methoxide or bromide on the ortho position. Using these ligands, alcohols with ee's of up to 99% are formed.
New varistor material (1988)

A composite varistor material containing silicon carbide, a conductor, and an insulator has been developed. The material has rubberlike flexibility and is easily formed. A higher leakage resistivity (∼1012 Ω cm) and greater nonlinearity (∼10) than for silicon carbide varistors permit the material to be used as a gapless surge suppressor. The breakdown voltage (1–10 kV/cm) and other properties of the material vary with composition. High current capability (&gt;200 A/cm2) and good energy absorption (&gt;40 J/cm3) are obtained. Also, the material exhibits a low-temperature coefficient (∼4×10−3/K) and a low dielectric constant (∼10) with no observed loss peak.
Mistletoe Lectin I Is a Sialic Acid-Specific Lectin with Strict Preference to Gangliosides and Glycoproteins with Terminal Neu5Acα2−6Galβ1−4GlcNAc Residues (2004)

Mistletoe lectin I (ML-I) is a type II ribosome-inactivating protein, which inhibits the protein biosynthesis at the ribosomal level. ML-I is composed of a catalytically active A-chain with rRNA N-glycosidase activity and a B-chain with carbohydrate binding specificities. Using comparative solid-phase binding assays along with electrospray ionization tandem mass spectrometry, ML-I was shown to preferentially bind to terminally alpha2-6-sialylated neolacto series gangliosides from human granulocytes. IV(6)Neu5Ac-nLc4Cer, VI(6)Neu5Ac-nLc6Cer, and VIII(6)Neu5Ac-nLc8Cer were identified as ML-I receptors, whereas the isomeric alpha2-3-sialylated neolacto series gangliosides were not recognized. Only marginal binding of ML-I to terminal galactose residues of neutral glycosphingolipids with a Galbeta1-4Glc or Galbeta1-4GlcNAc sequence was determined, whereas a distal Galalpha1-4Gal, GalNAcbeta1-3Gal, or GalNAcbeta1-4Gal disaccharide did not bind at all. Among the glycoproteins investigated in Western blot and microwell adsorption assays, only those carrying Neu5Acalpha2-6Galbeta1-4GlcNAc residues, exclusively, predominantly, or even as less abundant constituents in an assembly with Neu5Acalpha2-3Galbeta1-4GlcNAc-terminated glycans, displayed high ML-I binding capacity. From our data we conclude that (i) ML-I has to be considered as a sialic acid- and not a galactose-specific lectin and (ii) neolacto series gangliosides and sialoglycoproteins with type II glycans, which share the Neu5Acalpha2-6Galbeta1-4GlcNAc terminus, are true ML-I receptors. This strict preference might help to explain the immunostimulatory potential of ML-I toward certain leukocyte subpopulations and its therapeutic success as a cytotoxic anticancer drug.
Skin cancer imaging device speeds diagnosis (2019)

A new technology based on laser-induced breakdown spectroscopy has demonstrated accuracy in both sensitivity and specificity for discriminating skin cancers from benign lesions, one expert says.
Catalytic dehydration of glycerol in sub- and supercritical water: a new chemical process for acrolein production (2005)

Investigations on using renewables as alternative raw materials for intermediates are becoming more and more important as the crude oil and natural gas resources will be exhausted in a few decades. Acrolein is an important and versatile intermediate for the chemical industry, e.g. for the production of acrylic acid esters, superabsorber polymers or detergents. Up to now, the production route is the gas phase oxidation of propylene with a Bi/Mo-mixed oxide catalyst. As an alternative, acrolein can be produced by the dehydration of glycerol, which appears as a basic component of natural fats and is accumulated to a great extent as a by-product during fat saponification and biodiesel production. Here, the usage of sub- and supercritical water as the reaction media has shown a certain potential for the dehydration of glycerol, although the conversion and acrolein selectivities which have been achieved so far, are not satisfying for an economical process. Only the addition of mineral acid leads to sufficient acrolein yields. To evade the disadvantage of intensifying corrosion, the influence of the addition of electrolytes such as zinc sulfate on this reaction has been investigated. Experiments were conducted in a high pressure plug flow reactor from 300–390 °C, 25–34 MPa, 10–60 s residence time and varying amounts of zinc sulfate. It was shown that in the near subcritical temperature, increasing the amount of salt enhances the glycerol conversion. The maximum acrolein selectivity is 75 mol% at 360 °C, 25 MPa, 470 ppm (g g−1) zinc sulfate and a conversion of 50%. The activation volume was determined to be −(274 ± 65) cm3 mol−1 (at 360 °C, 25–34 MPa and 790 ppm (g g−1) zinc sulfate) and it turned out that the addition of zinc sulfate causes a decrease of the activation energy from 150 kJ mol−1 to (140 ± 12) kJ mol−1.
Systemic Corticosteriod Rapidly Reverses Bronchodilator Subsensitivity Induced by Formoterol in Asthmatic Patients (1997)

There is evidence that downregulation and desensitization of airway beta 2-adrenoceptors (beta 2-AR) develops after continuous exposure to long-acting beta 2-agonists such as formoterol and salmeterol. To investigate the facilitatory effects of acute administration of systemic corticosteroid on bronchodilator subsensitivity, as might occur in the setting of acute asthma, 12 subjects with moderately severe asthma, with a mean FEV1 of 66% predicted, of whom were all receiving inhaled corticosteriod, were randomized to receive either inhaled placebo (PL) or inhaled formoterol (FM) 24 micrograms twice daily for 4 wk in a double-blind crossover study. Subjects were also genotyped in terms of beta 2-Ar polymorphism at loci 16 and 27. A dose-response curve (DRC) and duration-time profile for FM (12 to 108 micrograms) was produced 1 h after administration of placebo tablets and after injection at 3 wk, and 1 h after administration of oral prednisolone, 50 mg, and intravenous hydrocortisone, 200 mg, at 4 wk. Comparisons between treatments were made with area-under-curve (AUC) measurements as the change from baseline. There was a significant rightward shift in the DRC after FM as opposed to placebo for delta FEV1 (as AUC, L.h): 2.51 versus 4.22 (95% CI: 0.54 to 2.89; p = 0.01) and delta FEF25-75 (as AUC, L x 10(3)): 11.30 versus 19.94 (95% CI: 2.12 to 15.12; p = 0.01). This was significantly reversed by steroid (S) for FEV1 (FM versus FM+5): 2.51 versus 3.57 (95% CI: 0.11 to 2.27; p = 0.03) and for FEF25-75: 11.30 versus 18.47 (95% CI: 2.52 to 11.70; p = 0.005). Lymphocyte beta 2-AR density (log Bmax; fmol/10(6) cells) showed significant upregulation 3 h after steroid (FM+5 versus FM): 0.34 versus 0.24 (95% CI: 0.02 to 0.18; p = 0.01). For heart-rate response (as AUC, beats), there was subsensitivity with FM versus PL: 2,700 versus 5,200 (95% CI: 40 to 5,000; p < 0.001), and this was reversed by steroid (FM+5 versus FM): 9,600 versus 2,700 (95% CI: 4,900 to 8,800; p < 0.001). This reversal by systemic corticosteroid appears to be generally independent of beta 2-AR polymorphism at loci 16 and 27. In conclusion, we have demonstrated that bronchodilator subsensitivity occurs after regular inhaled FM in asthmatic patients, and is rapidly reversed by systemic corticosteroid. Thus, in acute asthma, systemic corticosteroid should be administered a soon as possible, in order to restore normal airway beta 2-AR sensitivity, particularly in patients who are receiving regular long-acting beta 2-agonists.
<i>In vivo</i> high‐resolution volume‐selected proton spectroscopy and <i>T</i><sub>1</sub> measurements in the dog brain (1989)

Successful in vivo NMR spectroscopy requires a combination of techniques to address the problems of volume selection, water suppression, and resolution. All this needs to be done in the very heterogeneous environment found in living organisms. Previously published techniques are used to obtain 1H spectra from a dog brain, observing metabolites with concentrations below 1 mM. Measurements of spin-lattice relaxation times (T1) are also presented. The 1H relaxation times are long (T1 greater than 1.0 s) yielding information about the fluidity of the molecular environment. Comments are made concerning the achievable linewidth in vivo and the deficiencies that phase-encoding spectroscopic methods may have in obtaining high-resolution 1H spectra.
Identification of the Protein Encoded by the E6 Transforming Gene of Bovine Papillomavirus (1985)

Papillomaviruses (PV) contain several conserved genes that may encode nonstructural proteins; however, none of these predicted gene products have been identified. Papillomavirus E6 genes are retained and expressed as RNA in PV-associated human and animal carcinomas and cell lines. This suggests that the E6 gene product may be important in the maintenance of the malignant phenotype. The E6 open reading frame of the bovine papillomavirus (BPV) genome has been identified as one of two BPV genes that can independently transform mouse cells in vitro. A polypeptide encoded by this region of BPV was produced in a bacterial expression vector and used to raise antisera. The antisera specifically immunoprecipitated the predicted 15.5-kilodalton BPV E6 protein from cells transformed by the E6 gene. The E6 protein was identified in both the nuclear and membrane fractions of these transformed cells.
Organization and Expression of Genes Encoding Prostatic Steroid Binding Protein (1984)

We have cloned the genes for prostatic steroid binding protein to study the mechanism whereby their expression is regulated by testosterone. The genes for the C1 and C2 polypeptides are probably unique whereas there are two genes C3(1) and C3(2) for the C3 polypeptide of which only the former is transcribed in vivo. The state of DNA methylation associated with the two genes for C3 also differ, insofar as C3(1) is demethylated in ventral prostate from 14-28 days of age, whereas the C3(2) gene remains hypermethylated. The organization of all four genes is similar and appreciable DNA sequence homologies suggest that they may have arisen from a single ancestral gene. To study C3 expression and its hormonal regulation we have introduced the cloned genes into mouse S115 cells, an androgen-responsive cell line. Both genes were accurately transcribed and their expression was stimulated up to fivefold by 10(-8) M testosterone in approximately one third of the clones tested. To delineate the site of action of the hormone we have constructed chimeric genes consisting of putative C3 promoters and regulatory sequences together with a marker gene, interferon. This chimeric gene resulted in interferon production but its expression was stimulated by less than twofold in all clones tested. Therefore, these results indicate that, in mouse cells, testosterone does not interact directly with the rat C3 promoter but, in certain clones, may act post-transcriptionally.
Synthese und physikalische Eigenschaften neuer 2,2′‐verbrückter Bis(1,3‐dithiolylium‐4‐olate) (1987)

Abstract Die Synthese und physikalischen Eigenschaften der neuen Titelverbindungen vom Typ 4,8 und 11 , die zwei gleiche mesoionische Systeme über die 2‐Stellungen gebunden enthalten, sowie das Oligomerisierungsverhalten von 4b werden beschrieben.
Full-Capacity Unitary Recurrent Neural Networks (2016)

Recurrent neural networks are powerful models for processing sequential data, but they are generally plagued by vanishing and exploding gradient problems. Unitary recurrent neural networks (uRNNs), which use unitary recurrence matrices, have recently been proposed as a means to avoid these issues. However, in previous experiments, the recurrence matrices were restricted to be a product of parameterized unitary matrices, and an open question remains: when does such a parameterization fail to represent all unitary matrices, and how does this restricted representational capacity limit what can be learned? To address this question, we propose full-capacity uRNNs that optimize their recurrence matrix over all unitary matrices, leading to significantly improved performance over uRNNs that use a restricted-capacity recurrence matrix. Our contribution consists of two main components. First, we provide a theoretical argument to determine if a unitary parameterization has restricted capacity. Using this argument, we show that a recently proposed unitary parameterization has restricted capacity for hidden state dimension greater than 7. Second, we show how a complete, full-capacity unitary recurrence matrix can be optimized over the differentiable manifold of unitary matrices. The resulting multiplicative gradient step is very simple and does not require gradient clipping or learning rate adaptation. We confirm the utility of our claims by empirically evaluating our new full-capacity uRNNs on both synthetic and natural data, achieving superior performance compared to both LSTMs and the original restricted-capacity uRNNs.
Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas (2013)

The Cancer Genome Atlas Pan-Cancer Analysis Working Group collaborated on the Synapse software platform to share and evolve data, results and methodologies while performing integrative analysis of molecular profiling data from 12 tumor types. The group's work serves as a pilot case study that provides (i) a template for future large collaborative studies; (ii) a system to support collaborative projects; and (iii) a public resource of highly curated data, results and automated systems for the evaluation of community-developed models.
A Quadruply Azulene‐Fused Porphyrin with Intense Near‐IR Absorption and a Large Two‐Photon Absorption Cross Section (2006)

Extending conjugation: Azulene-fused porphyrins (see example) are synthesized through the oxidation of meso-(4-azulenyl)porphyrins with FeCl3. The azulene-fused strategy allowed highly π-conjugated porphyrinic electronic systems, which are promising two-photon absorption pigments, to be realized. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600892_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Synchrotron x-ray microbeam diagnostics of combinatorial synthesis (1998)

X-ray microbeam techniques (spot size=3×20 μm2) have been applied to characterize the composition and structure of rare earth activated Gd(La, Sr)AlO3 phosphor thin films grown by combinatorial synthesis. Using x-ray fluorescence, x-ray diffraction and near-edge x-ray absorption spectroscopy, we have measured the chemical composition, crystallographic structure, and valence state of the rare earth activator atom Eu. These measurements represent the direct application of x-ray techniques to solid-state materials prepared by combinatorial synthesis and demonstrate the power of x-ray microbeam analysis to nondestructively characterize as-grown combinatorial libraries.
Confirmation of the laboratory synthesis of neutrons from a hydrogen gas (2015)

We review theoretical studies on the synthesis of the neutron from the hydrogen atom in the core of stars; we outline tests conducted in the 1960s on the laboratory synthesis of the neutron by C. Borghi and his collaborators; we outline the confirmat
No evidence of increased adverse drug reactions in cytochrome P450<i>CYP2D6</i>poor metabolizers treated with fluoxetine or nortriptyline (2004)

The polymorphic enzyme cytochrome P450 CYP2D6 is involved in the metabolism of many antidepressants, including nortriptyline and fluoxetine. Some 7%-10% Caucasians have inactivating mutations in both alleles of the CYP2D6 gene, and are referred to as poor metabolizers (PMs). Several case reports and clinical studies suggest that CYP2D6 PMs are at a greater risk of developing adverse drug reactions (ADRs) on antidepressant medication than extensive metabolizers (EMs). However, few clinical trials have investigated whether CYP2D6 PM genotype is predictive of ADRs during antidepressant treatment. This paper explores the link between CYP2D6 genotype and antidepressant-associated ADRs in outpatients being treated for major depression with either nortriptyline or fluoxetine. Patients were randomized to fluoxetine (n=65) or nortriptyline (n=60) for the 6 week trial. CYP2D6 genotypes predicted that of these patients 115 were EM and the remaining 10 were PMs. ADRs attributed to antidepressant usage were recorded over the 6-week trial. Although the type of ADR was, as expected, different between drugs, the frequency of ADRs experienced did not differ significantly between the two antidepressants or between CYP2D6 PMs and EMs. In addition, the frequency at which PMs discontinued antidepressant medication was not noticeably different from EMs, although with only 10 PMs the study is under powered to detect moderate or small differences. These findings suggest that inability to efficiently metabolize antidepressants that are CYP2D6 substrates does not necessarily lead to increased occurrence of antidepressant-associated ADRs. Thus, for clinicians prescribing antidepressant monotherapy, CYP2D6 polymorphisms are probably not of relevance to antidepressant side effects and therapy.
A Bayesian Method for Short-Term Probabilistic Forecasting of Photovoltaic Generation in Smart Grid Operation and Control (2013)

A new short-term probabilistic forecasting method is proposed to predict the probability density function of the hourly active power generated by a photovoltaic system. Firstly, the probability density function of the hourly clearness index is forecasted making use of a Bayesian auto regressive time series model; the model takes into account the dependence of the solar radiation on some meteorological variables, such as the cloud cover and humidity. Then, a Monte Carlo simulation procedure is used to evaluate the predictive probability density function of the hourly active power by applying the photovoltaic system model to the random sampling of the clearness index distribution. A numerical application demonstrates the effectiveness and advantages of the proposed forecasting method.
Molecular Weight Determination of Phospholamban Oligomer in the Presence of Sodium Dodecyl Sulfate: Application of Low-Angle Laser Light Scattering Photometry1 (1991)

The number of polypeptides constituting the oligomeric structure of canine phospholamban (a putative regulator of Ca(2+)-ATPase of cardiac sarcoplasmic reticulum) stable even in the presence of sodium dodecyl sulfate was estimated through determination of the molecular weight of the oligomer. Owing to the small molecular size, the low UV-absorptivity and the limited availability, the molecular weight determination required very sophisticated application of the following technique, used as the only recourse: low-angle laser light scattering measurement combined with high-performance gel chromatography. The molecular weight of phospholamban oligomer was found to be 30,400 and the number of subunits was concluded to be five after correction for the dependence of the apparent molecular weights on the protein concentration.
Transaction Time Support Inside a Database Engine (2006)

Transaction time databases retain and provide access to prior states of a database. An update "inserts" a new record while preserving the old version. Immortal DB builds transaction time database support into a database engine, not in middleware. It supports as of queries returning records current at the specified time. It also supports snapshot isolation concurrency control. Versions are stamped with the "clock times" of their updating transactions. The timestamp order agrees with transaction serialization order. Lazy timestamping propagates timestamps to transaction updates after commit. Versions are kept in an integrated storage structure, with historical versions initially stored with current data. Time-splits of pages permit large histories to be maintained, and enable time based indexing, which is essential for high performance historical queries. Experiments show that Immortal DB introduces little overhead for accessing recent database states while providing access to past states.
Characterization of an Aldolase−Dehydrogenase Complex That Exhibits Substrate Channeling in the Polychlorinated Biphenyls Degradation Pathway (2009)

An aldolase and dehydrogenase complex from the polychlorinated biphenyl degradation pathway of the bacterium Burkholderia xenovorans LB400 was purified. The aldolase, BphI, had the highest activity with Mn(2+) as the cofactor and was able to transform 4-hydroxy-2-oxopentanoate and 4-hydroxy-2-oxohexanoate to pyruvate and acetaldehyde or propionaldehyde with similar specificity constants. Aldolase activity was competitively inhibited by the pyruvate enolate analogue, oxalate, with a K(ic) of 0.93 microM. The pH-rate profiles suggested the involvement of a pK(a) 7.7 catalytic base in the reaction mechanism. BphI activity was activated 15-fold when substrate turnover was occurring in the dehydrogenase, BphJ, which can be attributed partially to nicotinamide coenzyme binding to BphJ. BphJ had similar specificity constants for acetaldehyde or propionaldehyde and was able to utilize aliphatic aldehydes from two to five carbons in length as substrates, although K(m) values for these aldehyes were >20 mM. When 4-hydroxy-2-oxopentanoate was provided as a substrate to the BphI-BphJ complex in a coupled enzyme assay, no lag in the progress curve of BphJ was observed. When 1 mM propionaldehyde was added exogenously to a reaction mixture containing 0.1 mM 4-hydroxy-2-oxopentanoate, 95% of the CoA esters produced was acetyl CoA. Conversely, 99% of the CoA esters produced was propionyl CoA when a 10-fold molar excess of exogenous acetaldehyde was added in a reaction mixture containing 4-hydroxy-2-oxohexanoate. These results demonstrate that acetaldehyde and propionaldehyde, products of the BphI reaction, are not released in the bulk solvent but are channeled directly to the dehydrogenase.