gebhart/patrepeval huggingface dataset:
Effect of Mycobacterium tuberculosis and its components on macrophages and the release of matrix metalloproteinases. (1996)

These data suggest that M tuberculosis and its major cell antigenic component, LAM, stimulate the release of MMP-9 and upregulate the expression of genes for MMP-1 and MMP-9. It is possible that M tuberculosis and its components contribute directly to cavity formation by their ability to stimulate macrophages to release matrix metallo-proteinases that digest collagens I-IV, and indirectly by stimulating the release of the cytokines interleukin 1 beta and tumour necrosis factor alpha that induce fibroblasts to amplify the release of matrix metalloproteinases.
Near-field intensity correlations of scattered light (2001)

We show that the two-point correlation function in the near field of scattered light is simply related to the scattered intensity distribution. We present a new, to our knowledge, optical scheme to measure the correlation function in the near field, and we describe a processing technique that permits the subtraction of stray light on a statistical basis. We present experimental data for solutions of latex spheres, and we show that this novel technique is a powerful alternative to static light scattering.
Pore Environment Effects on Catalytic Cyclohexane Oxidation in Expanded Fe<sub>2</sub>(dobdc) Analogues (2016)

Metal-organic frameworks are a new class of heterogeneous catalysts in which molecular-level control over both the immediate and long-range chemical environment surrounding a catalytic center can be readily achieved. Here, the oxidation of cyclohexane to cyclohexanol and cyclohexanone is used as a model reaction to investigate the effect of a hydrophobic pore environment on product selectivity and catalyst stability in a series of iron-based frameworks. Specifically, expanded analogues of Fe<sub>2</sub>(dobdc) (dobdc<sup>4-</sup> = 2,5-dioxido-1,4-benzenedicarboxylate) were synthesized and evaluated, including the biphenyl derivative Fe<sub>2</sub>(dobpdc) (H<sub>4</sub>dobpdc = 4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid), the terphenyl derivative Fe<sub>2</sub>(dotpdc) (H<sub>4</sub>dotpdc = 4,4″-dihydroxy-[1,1':4',1″-terphenyl]-3,3″-dicarboxylic acid), and three modified terphenyl derivatives in which the central ring is replaced with tetrafluoro-, tetramethyl-, or di-tert-butylaryl groups. Within these five materials, a remarkable 3-fold enhancement of the alcohol:ketone (A:K) ratio and an order of magnitude increase in turnover number are achieved by simply altering the framework pore diameter and installing nonpolar functional groups near the iron site. Mössbauer spectroscopy, kinetic isotope effect, and gas adsorption measurements reveal that variations in the A:K selectivities arise from differences in the cyclohexane adsorption enthalpies of these frameworks, which become more favorable as the number of hydrophobic residues and thus van der Waals interactions increase.
A functional model for vanadium haloperoxidase (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA functional model for vanadium haloperoxidaseGerard J. Colpas, Brent J. Hamstra, Jeff W. Kampf, and Vincent L. PecoraroCite this: J. Am. Chem. Soc. 1994, 116, 8, 3627–3628Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ja00087a070https://doi.org/10.1021/ja00087a070research-articleACS PublicationsRequest reuse permissionsArticle Views523Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin- II-responsive aldosterone secretion (1993)

Excessive secretion of aldosterone from the adrenal results in the most common form of endocrine hypertension. An understanding of the regulatory processes involved in aldosterone synthesis and release is needed to define the biomolecular mechanisms controlling excessive production of aldosterone. However, in vitro studies regarding the regulatory mechanisms of human aldosterone production have been limited because of difficulties in obtaining tissue and the subsequent isolation of aldosterone-secreting glomerulosa cells. Herein we describe an adrenocortical carcinoma cell line, NCI-H295, which provides a suitable angiotensin-II (AII)-responsive model system to investigate the acute and chronic regulation of aldosterone synthesis. The cells were characterized with regard to the effects of AII on second messenger systems, aldosterone release, and levels of aldosterone synthase (P450c18) mRNA. In the presence of lithium, AII caused a rapid, but transient, increase in the production of inositol tris- and bisphosphates, whereas a prolonged gradual accumulation of inositol monophosphate occurred. Treatment with AII resulted in a 4.5-fold increase in total inositol phosphates in a concentration-dependent manner and an increase in intracellular cytoplasmic free Ca2+. Significant increases in aldosterone (3.5-fold) were detected within 1 h of AII addition. Aldosterone release occurred in a concentration-and time-dependent manner. The type 1 AII (AT1) receptor was shown to be responsible for activation of phosphoinositidase-C, increased intracellular free Ca2+, and aldosterone production, as determined by use of the AT1 receptor antagonist DuP753. In addition, AII treatment resulted in a time-dependent increase in levels of P450c18 mRNA, as detected by RNAse protection assay. In summary, NCI-H295 cells provide a valuable model system to define mechanisms regulating human aldosterone production.
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells (2013)

Melatonin exerts an anti-angiogenic activity in HepG2 cells by interfering with the transcriptional activation of VEGF, via Hif1α and STAT3. Our results provide evidence to consider this indole as a powerful anti-angiogenic agent for HCC treatment.
Protocol portability through module encapsulation (2002)

Because protocol software is difficult and expensive to implement and test, it is often ported between systems instead of rewritten from scratch. Unfortunately, porting protocol software can be as difficult as from-scratch development, due to inherent differences in subsystem design. Thus, protocol subsystems can have a profound effect on the portability of a protocol implementation. We propose an approach permitting the incorporation of new protocols into a subsystem other than their "native" one without the drawbacks or expense of porting and original development. Our approach is based on protocol module encapsulation, which allows unmodified protocol code developed for one protocol subsystem to be used within another. We relate our experiences designing, implementing, and measuring the performance of our protocol encapsulation modules, using an AppleTalk protocol stack as a baseline.
Ship Surveillance With TerraSAR-X (2010)

Ship detection is an important application of global monitoring of environment and security. In order to overcome the limitations by other systems, surveillance with satellite synthetic aperture radar (SAR) is used because of its possibility to provide ship detection at high resolution over wide swaths and in all weather conditions. A new X-band radar onboard the TerraSAR-X (TS-X) satellite gives access to spatial resolution as fine as 1 m. In this paper, first results on the combined use of TS-X ship detection, automatic identification system (AIS), and satellite AIS (SatAIS) is presented. The AIS system is an effective terrestrial method for tracking vessels in real time typically up to 40 km off the coast. SatAIS, as a space-based system, allows almost global coverage for monitoring of ships since not all ships operate their AIS and smaller ships are not equipped with AIS. The system is considered to be of cooperative nature. In this paper, the quality of TS-X images with respect to ship detection is evaluated, and a first assessment of its performance for ship detection is given. The velocity of a moving ship is estimated using complex TS-X data. As test cases, images were acquired over the North Sea, Baltic Sea, Atlantic Ocean, and Pacific Ocean in Stripmap mode with a resolution of 3 m at a coverage of 30 km <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\times$</tex></formula> 100 km. Simultaneous information on ship positions was available from TS-X and terrestrial as well as SatAIS. First results on the simultaneous superposition of SatAIS and high-resolution radar images are presented.
Switchable Pickering Emulsions Stabilized by Silica Nanoparticles Hydrophobized <i>in Situ</i> with a Conventional Cationic Surfactant (2015)

A stable oil-in-water Pickering emulsion stabilized by negatively charged silica nanoparticles hydrophobized in situ with a trace amount of a conventional cationic surfactant can be rendered unstable on addition of an equimolar amount of an anionic surfactant. The emulsion can be subsequently restabilized by adding a similar trace amount of cationic surfactant along with rehomogenization. This destabilization-stabilization behavior can be cycled many times, demonstrating that the Pickering emulsion is switchable. The trigger is the stronger electrostatic interaction between the oppositely charged ionic surfactants compared with that between the cationic surfactant and the (initially) negatively charged particle surfaces. The cationic surfactant prefers to form ion pairs with the added anionic surfactant and thus desorbs from particle surfaces rendering them surface-inactive. This access to switchable Pickering emulsions is easier than those employing switchable surfactants, polymers, or surface-active particles, avoiding both the complicated synthesis and the stringent switching conditions.
New structural insights from Raman spectroscopy of proteins and their assemblies (2002)

Protein structure and stability are sensitive to and dependent on the local interactions of amino acid side chains. A diverse and important type of side-chain interaction is the hydrogen bond. Although numerous hydrogen bonds are resolved in protein 3-dimensional structures, those of the cysteine sulfhydryl group (S-H) are elusive to high-resolution X-ray and NMR methods. However, the nature and strength of sulfhydryl hydrogen bonds (S-H* * *X) are amenable to investigation by Raman spectroscopy. The power of the Raman method for characterizing S-H* * *X interactions is illustrated by resolving the Raman S-H stretching band for each of the eight cysteines per 666-residue subunit in the trimeric tailspike of icosahedral bacteriophage P22. The Raman sulfhydryl signatures of the wild-type tailspike and eight single-site cysteine to serine mutants reveal a heretofore unrecognized diversity of S-H hydrogen bonds in a native protein. The use of Raman spectroscopy to identify the non-hydrogen-bonded state of the tyrosine phenoxyl group is also described. This unusual and unexpected state occurs for all tyrosines in the assembled capsids of filamentous viruses Ff and Pf1. The Raman spectral signature of the non-hydrogen-bonded tyrosine phenoxyl, which is characterized by an extraordinary Raman Fermi doublet intensity ratio (I850/I830 = 6.7), extends and refines the existing correlation for hydrogen-bonded tyrosines. Finally, a novel Raman signature for tryptophan in the Pf3 filamentous virus is identified, which is proposed as diagnostic of "cation-pi interaction" involving the guanidinium group of Arg 37 as a cation donor and the indolyl ring of Trp 38 as a pi-electron acceptor. These studies demonstrate the power of Raman spectroscopy for investigating the interactions of key side chains in native protein assemblies.
Cecropin D-like antibacterial peptides from the sphingid moth,Agrius convolvuli (1999)

Two major antibacterial peptides were isolated and purified from immunized larval hemolymph of Agrius convolvuli. Acid extraction, gel filtration, ultrafiltration, and reversed-phase FPLC were used for purification of peptides. These peptides had similar molecular mass and amino acid composition. Moreover, 21 of the first 23 N terminal residues were identical. The peptides were highly homologous with cecropin D in size and primary sequence, and named Agrius cecropin D1 and D2. The molecular masses of Agrius cecropin D1 and D2 were 3,879.39 and 3,839.27, respectively. In antibacterial and hemolytic assays, Agrius cecropin D showed potent antibacterial activities against a panel of Gram positive and negative bacteria without hemolytic activity against human red blood cells. Notably, our antibacterial assay revealed Agrius cecropin D possessed stronger or at least equivalent activities against B. megaterium than cecropin A. It suggests that Agrius cecropin D, which has an alternative structure from cecropin D, could be the model for the development of peptide antibiotics. Arch.
Prediction Refinement with Optical Flow for Affine Motion Compensation (2019)

Affine motion compensation (AMC) has been adopted in the latest working draft of the Versatile Video Coding (VVC) standard jointly developed by ITU-T VCEG and ISO/IEC MPEG. The AMC in the VVC working draft is implemented as a sub-block based MC rather than pixel-based MC in order to reduce the memory access bandwidth and computation complexity, which loses prediction efficiency. The proposed algorithm in this paper is to improve the MC granularity by using pixel-based optical flow refinement. The affine prediction efficiency will be close to the pixel-based MC refinement without increasing external memory access. The experiment results show that on average the proposed algorithm can achieve 0.86% and 0.87% BD rate saving for random access and low delay B configurations, respectively, comparing to the VTM-4.0. The BD rate saving is up to 3.10%.
Organometallic and enzymatic catalysis for ring opening copolymerization of ε‐caprolactone and 4‐methyl‐ε‐caprolactone (2011)

Abstract A series of copolymers containing ε‐caprolactone (CL) and 4‐methyl‐ε‐caprolactone (MeCL) were synthesized by ring‐opening polymerization (ROP) using Tin(II) bis(2‐ethylhexanoate)(Sn(Oct) 2 ) or Novozym 435 as catalyst. The molecular structure and weight of copolymers were determined by nuclear magnetic resonance (NMR) and size exclusion chromatography (SEC), respectively. Our kinetic study showed that the monomer reactivity ratios for CL ( r 1 ) and MeCL ( r 2 ) using Sn(Oct) 2 as catalyst were estimated to be near unity and r 1 × r 2 = 1, indicating the random distribution of the monomers in the final copolymer. The results of DSC and XRD consistently indicated that the copolymers were inclined to be amorphous with the increasing of MeCL fraction. Microspheres were prepared from copolymers and characterized by SEM. The preliminary degradability and biocompatibility studies on these copolymers were also assessed. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
The Burden of Mycobacterial Disease in Ethiopian Cattle: Implications for Public Health (2009)

Our analysis has revealed that bTB is widely spread throughout Ethiopia, albeit at a low prevalence, and provides underpinning evidence for public health policy formulation.
Linear Force Coefficients for Squeeze-Film Dampers (1983)

This paper presents a simplifed analysis of viscous squeeze-film damper behavior. It makes use of the notation of averaged inertia and calculates linear velocity and inertia coeffcients. These coefficients are shown to be accurate at practical values of the length/diameter ratio and the gap Reynolds number of the viscous damper.
A direct route for the synthesis of (E)-3-alkyl-4-oxo-2-butenoic acid esters (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA direct route for the synthesis of (E)-3-alkyl-4-oxo-2-butenoic acid estersSylvain Laugraud, Andre Guingant, and Jean D'AngeloCite this: J. Org. Chem. 1987, 52, 21, 4788–4790Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/jo00230a026https://doi.org/10.1021/jo00230a026research-articleACS PublicationsRequest reuse permissionsArticle Views404Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nichtlineare Regelung von Kraftfahrzeugen in querdynamisch kritischen Fahrsituationen (2008)

Diese Arbeit stellt ein nichtlineares Regelungskonzept vor, das eine beliebige Kombination der drei Stelleingriffe radindividuelles Bremsen, Vorder- und Hinterachslenkung ermöglicht. Durch Gain Scheduling linearer PI-Zustandsregler können die beiden zentralen Größen der Fahrzeugquerdynamik, Schwimmwinkel und Gierrate, gemeinsam geregelt werden. Das Gesamtkonzept umfasst neben einem Extended Kalman Filter zur Schwimmwinkelschätzung auch die Detektion kritischer Fahrsituationen.
Dual Effect of Light on the Gibberellin- and Nitrate-Stimulated Seed Germination of <i>Sisymbrium officinale</i> and <i>Arabidopsis thaliana</i> (1988)

Red light (R) has a dual effect on the seed germination of the two related species Arabidopsis thaliana and Sisymbrium officinale. The two species provide different means to separate the light-effects. In S. officinale, stimulation of germination by R depends on the stimultaneous presence of nitrate (light-effect I). The effect of both factors is completely blocked by tetcyclacis, an inhibitor of gibberellin (GA)-biosynthesis. Addition of a mixture of gibberellins A(4) and A(7) (GA(4+7)) antagonizes the inhibition. In the absence of nitrate, R shifts germination to lower GA-requirement (light-effect II). In A. thaliana a similar second light-effect is seen on the GA-requirement of GA-deficient ga-1 mutant seeds. R stimulates germination of wild type seeds in water (light-effect I). For both species, light-effect I shows a fluence threshold value of approximately 10(-5) moles per square meter, which is independent of the nitrate concentration. Increasing nitrate concentrations narrow the fluence-range required for maximal germination whereby the product of nitrate concentration and fluence value determines the germination level, indicating a multiplicative interaction between R and nitrate. Fluence-response curves for light-effect II are similar for both species. Germination occurs in the range of 10(-6) to 10(-2) moles per square meter fluence. The maximal level of germination is determined by the level of dark-germination and light-effect II. Increasing GA(4+7) concentrations induce a shift to lower fluence values. It is shown that in the second effect the co-action of R and exogenous GA(4+7) is clearly additive. It is concluded that light-effect I induces a chain of events leading to GA biosynthesis. Light-effect II seems to enhance the sensitivity of the seeds to GAs.
High-resolution through-the-wall radar imaging algorithm based on ARMA model (2009)

Radar through wall detecting is a kind of new technology of exploring.In this paper,a continuous-wave low-complexity dual-frequency Doppler radar and the basic algorithm for detecting moving targets behind barriers is present briefly.After analyzing the main characteristics of the algorithm,A ARMA(Auto-Regressive Moving Average) model is introduced to improve the poor resolution which is one of the main drawbacks of the traditional Doppler radars.Simulate the imaging results,including both the traditional algorithm and the ARMA-based algorithm circumstance.Comparing the results,the efficiency and the priority of the new algorithm is proved.
WQ Studying Plays an Important Role in Creative Practice (2004)

In current domestic and international situations, creative practice has become the main practice style, and the WQ studying plays an important role in it. Firstly, WQ is another basic factor of creative practice. We know that IQ and EQ are basic factors of creative practice, and more and more studies clarify WQ as another factor. Secondly, WQ is important power that affects the success of creative practice, because every creative practice can not expect results overnight. At the end, thoughts are the key of creativity. Creative practice needs the development of man' s creative thoughts, and WQ is an important promoting factor of creative thoughts.
Cloning, characterization and immunolocalization of human ameloblastin (2000)

Amelogenesis imperfecta is a broad classification of hereditary enamel defects, exhibiting both genetic and clinical diversity. Most amelogenesis imperfecta cases are autosomal dominant disorders, yet only the local hypoplastic form has been mapped to human chromosome 4q between D4S242 1 and the albumin gene. An enamel protein cDNA, termed ameloblastin (also known as amelin and sheathlin), has been isolated from rat, mouse and pig. Its human homolog has been mapped to chromosome 4q21 between markers D4S409 and D4S400, flanking the local hypoplastic amelogenesis imperfecta critical region. Therefore, ameloblastin is a strong candidate gene for this form of amelogenesis imperfecta. To facilitate genetic studies related to this dental disease, we isolated and characterized a human ameloblastin cDNA. A human third molar cDNA library was screened and two ameloblastin clones identified. Nucleotide sequencing of these cDNAs indicated alternative splicing of the putative open reading frame, use of different polyadenylation signals, and a high degree of similarity to reported rat, mouse and porcine cDNAs. Immunohistochemistry studies on embryonic human teeth using an antibody to recombinant ameloblastin indicated ameloblastin expression by ameloblasts with localization in the enamel matrix associated with the sheath structures.
Mixture of essential fatty acids lowers test anxiety (2005)

Test anxiety is an incapacitating academic syndrome. This study shows that administration of a polyunsaturated fatty acid mixture of omega-3 and -6 can improve the behavioral variables associated with this type of anxiety, i.e. appetite, mood, mental concentration, fatigue, academic organization and poor sleep, as well as lowering elevated cortisol level, with a corresponding reduction of anxiety.