gebhart/patrepeval huggingface dataset:
GM-CSF regulation in eosinophils. (2002)

Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of the hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in broncho-constriction, lung damage and, ultimately, fibrosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate that activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.
Transfer Printing for Silicon Photonics Transceivers and Interposers (2018)

We present transfer printing as an enabling technology to realize heterogeneous photonic integrated circuits. The approach enables a cost-effective and intimate integration of III-V lasers on advanced high-speed Si PICs. It also enables the integration of III-V and silicon-based opto-electronic components on a passive Si/SiN interposer.
Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib (2020)

ClinicalTrials.gov Identifier: NCT01658878.
Generating Diverse Plans Using Quantitative and Qualitative Plan Distance Metrics (2011)

Diversity-aware planning consists of generating multiple plans which, while solving the same problem, are dissimilar from one another. Quantitative plan diversity is domain-independent and does not require extensive knowledge-engineering effort, but can fail to reflect plan differences that are relevant to users. Qualitative plan diversity is based on domain-specific characteristics, thus being of greater practical value, but may require substantial knowledge engineering. We demonstrate a domain-independent diverse plan generation method that is based on customizable plan distance metrics and amenable to both quantitative and qualitative diversity. Qualitative plan diversity is obtained with minimal knowledge-engineering effort, using distance metrics which incorporate domain-specific content.
Limiting-dilution analysis of the frequency of myelin basic protein-reactive T cells in Lewis, PVG/c and BN rats. Implication for susceptibility to autoimmune encephalomyelitis. (1990)

Susceptibility to experimental autoimmune encephalomyelitis (EAE), which is an autoimmune disease inducible by immunization with a brain-specific antigen in complete Freund's adjuvant (CFA), is different among strains. In an attempt to resolve the immune mechanisms by which the difference in susceptibility to EAE is regulated, we re-estimated susceptibility of several strains of rats, and the frequency of antigen-reactive T cells in each strain was determined by limiting-dilution analysis. EAE was induced in Lewis (LEW), PVG/c and BN rats using four different methods: (i) active immunization with guinea-pig myelin basic protein (GPBP) in CFA; (ii) immunization with GPBP in CFA that had been further supplemented with Mycobacterium tuberculosis H37Ra (supplemented CFA); (iii) adoptive transfer of GPBP-activated spleen cells into syngeneic rats; and (iv) transfer of a GPBP-specific T-cell line. The LEW strain was susceptible to all four methods. The PVG/c strain was resistant to immunization with GPBP in conventional CFA (GPBP/conv. CFA), but was susceptible to immunization with GPBP in supplemented CFA (GPBP/suppl. CFA) and to transfer of activated spleen cells. The BN strain was resistant to all methods. Limiting-dilution analysis using T cells from LEW, PVG/c or BN rats has revealed that each strain of rat displays a different pattern of frequencies of GPBP-reactive or the 68-88 sequence (GP68-88)-reactive T cells. LEW rats showed relatively high frequencies of GPBP-reactive and GP68-88-reactive T cells after immunization with either GPBP/conv. CFA or GPBP/suppl. CFA, symptomatic rats showing higher values than asymptomatic rats. In asymptomatic PVG/c rats, the frequency of GP68-88-reactive T cells was lower than that of GPBP-reactive T cells. In PVG/c rats with clinical EAE, however, GP68-88-reactive T cells increased in frequency and were almost the same as GPBP-reactive T cells. BN rats, on the other hand, responded very poorly not only to the GP68-88 sequence but also to the whole GPBP molecule, even after immunization with GPBP/suppl. CFA. These findings, obtained by limiting-dilution analysis, strongly suggest that the development of EAE in LEW, PVG/c and BN rats is closely related to the frequency of GPBP-reactive T cells. Furthermore, it is shown that resistance to EAE found in PVG/c and BN rats may be generated by different immune mechanisms.
Dynamic organization of lymphocyte plasma membrane: lessons from advanced imaging methods (2010)

Lipids and lipid domains are suggested to play an essential role in the heterogeneous organization of the plasma membrane in eukaryotic cells, including cells of the immune system. We summarize the results of advanced imaging and physical studies of membrane organization with special focus on the plasma membrane of lymphocytes. We provide a comprehensive up-to-date view on the existence of membrane lipid and protein clusters such as lipid rafts and suggest research directions to better understand these highly dynamic entities on the surface of immune cells.
An ARQ technique using related parallel and serial concatenated convolutional codes (2002)

We propose a new type-II code-combining hybrid automatic repeat request (ARQ) strategy that uses both parallel and serial concatenated convolutional codes (PCCCs and SCCCs). The ARQ technique is based on the observation that a PCCC can be represented by an equivalent punctured SCCC. The initial transmission is the PCCC. When a retransmission is requested, the system only transmits the additional parity bits that, together with the previously transmitted PCCC bits, constitute the related SCCC. Simulation results show remarkable power efficiency and throughput efficiency when using the proposed system.
A Deep Learning Based Method For 3D Human Pose Estimation From 2D Fisheye Images (2018)

We propose a deep learning based method to directly estimate the human joint positions in 3D space from 2D fisheye images captured in an egocentric manner. The core of our method is a novel network architecture based on Inception-v3 [4], featuring the asymmtric convolutional filter size, the long short-term memory module, and the anthropomorphic weights on the training loss. We demonstrate our method outperform state-of-the-art method under different tasks. Our method can be helpful to develop useful deep learning network for human-machine interaction and VR/AR applications.
Development of Magnetic Resonance Imaging Contrast Material for <i>In vivo</i> Mapping of Tissue Transglutaminase Activity (2005)

Transglutaminases are a family of enzymes that play an important role in tissue remodeling by catalyzing covalent cross-links between proteins of the extracellular matrix. Elevated activity of transglutaminase was shown at the boundaries of invading tumors, in association with angiogenesis, in stabilization of atherosclerotic plaques, and in generation of blood clots. The aim of this work was to develop a low molecular weight substrate of transglutaminase that could serve for noninvasive magnetic resonance and optical mapping of transglutaminase-mediated cross-linking activity. A 2 kDa contrast material was generated which showed cross-linking by either tissue transglutaminase or factor XIII in the context of multicellular tumor spheroids or fibrin clots, respectively. Successful detection by nuclear magnetic resonance microscopy of transglutaminase-mediated cross-linking of the contrast material to MCF7 multicellular spheroids provides hope that this approach could potentially be developed for clinical demarcation of sites of transglutaminase activity.
Multipath cloud federation (2017)

Deploying applications in federated clouds is becoming increasingly important. The ability to place application components in various locations is appealing to a large set of distributed applications. Components spread across a number of clouds still need to communicate with each other. Existing solutions for interconnecting clouds are using only single paths between sites, even though clouds typically have multiple up-links. This paper introduces our work on a MultiPath TCP (MPTCP) proxy suited for cloud interconnection. The proxy transforms TCP streams into multipath connections using MPTCP. By virtue of MPTCP, the bandwidth of multiple links is made available to the proxied connections and resilience can be improved without the need for additional fail-over mechanisms. The proposed solution works transparently for applications, making changes to existing applications unnecessary. Measurements of the implemented scheme confirm the additional throughput achievable and the gain in resilience.
Improved Peptide Prodrugs of 5-ALA for PDT: Rationalization of Cellular Accumulation and Protoporphyrin IX Production by Direct Determination of Cellular Prodrug Uptake and Prodrug Metabolization (2009)

Twenty-seven dipeptide derivatives of general structure Ac-Xaa-ALA-OR were synthesized as potential prodrugs for 5-aminolaevulinic acid-based photodynamic therapy (ALA-PDT). Xaa is an alpha-amino acid, chosen to provide a prodrug with appropriately tailored lipophilicity and water solubility. Although no simple correlation is observed between downstream production of protoporphyrin IX (PpIX) in PAM212 keratinocytes and HPLC-derived descriptors of compound lipophilicity, quantification of prodrug uptake reveals that most of the dipeptides are actually more efficiently accumulated than ALA in PAM212 and also A549 and Caco-2 cell lines. Subsequent ALA release is the limiting factor, which emphasizes the importance of decoupling prodrug uptake and intracellular metabolization when assessing the efficacy of ALA derivatives for PDT. In agreement with PpIX fluorescence studies, at a concentration of 0.1 mM, l-Phe derivatives 4m and 4o, and l-Leu, l-Met, and l-Glu derivatives 4f, 4k, and 4u, exhibit significantly enhanced photoxicity in PAM212 cells compared to ALA.
Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors (2013)

CD40 is a cell-surface molecule that critically regulates immune responses. CP-870,893 is a fully human, CD40-specific agonist monoclonal antibody (mAb) exerting clinical antineoplastic activity. Here, the safety of CP-870,893 combined with carboplatin and paclitaxel was assessed in a Phase I study. Patients with advanced solid tumors received standard doses of paclitaxel and carboplatin on day 1 followed by either 0.1 mg/Kg or 0.2 mg/Kg CP-870,893 on day 3 (Schedule A) or day 8 (Schedule B), repeated every 21 d. The primary objective was to determine safety and maximum-tolerated dose (MTD) of CP-870,893. Secondary objectives included the evaluation of antitumor responses, pharmacokinetics and immune modulation. Thirty-two patients were treated with CP-870,893, 16 patients on each schedule. Two dose-limiting toxicities were observed (grade 3 cytokine release and transient ischemic attack), each at the 0.2 mg/Kg dose level, which was estimated to be the MTD. The most common treatment-related adverse event was fatigue (81%). Of 30 evaluable patients, 6 (20%) exhibited partial responses constituting best responses as defined by RECIST. Following CP-870,893 infusion, the peripheral blood manifested an acute depletion of B cells associated with upregulation of immune co-stimulatory molecules. T-cell numbers did not change significantly from baseline, but transient tumor-specific T-cell responses were observed in a small number of evaluable patients. The CD40 agonist mAb CP-870,893, given on either of two schedules in combination with paclitaxel and carboplatin, was safe for patients affected with advanced solid tumors. Biological and clinical responses were observed, providing a rationale for Phase II studies.
Relationship between serum total testosterone and prostate volume in aging men (2021)

Total testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs. 24.06 ± 6.77 P = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all P < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (P = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.
Semi-Automated Identification of N-Glycopeptides by Hydrophilic Interaction Chromatography, nano-Reverse-Phase LC–MS/MS, and Glycan Database Search (2012)

Glycoproteins fulfill many indispensable biological functions, and changes in protein glycosylation have been observed in various diseases. Improved analytical methods are needed to allow a complete characterization of this complex and common post-translational modification. In this study, we present a workflow for the analysis of the microheterogeneity of N-glycoproteins that couples hydrophilic interaction and nanoreverse-phase C18 chromatography to tandem QTOF mass spectrometric analysis. A glycan database search program, GlycoPeptideSearch, was developed to match N-glycopeptide MS/MS spectra with the glycopeptides comprised of a glycan drawn from the GlycomeDB glycan structure database and a peptide from a user-specified set of potentially glycosylated peptides. Application of the workflow to human haptoglobin and hemopexin, two microheterogeneous N-glycoproteins, identified a total of 57 distinct site-specific glycoforms in the case of haptoglobin and 14 site-specific glycoforms of hemopexin. Using glycan oxonium ions and peptide-characteristic glycopeptide fragment ions and by collapsing topologically redundant glycans, the search software was able to make unique N-glycopeptide assignments for 51% of assigned spectra, with the remaining assignments primarily representing isobaric topological rearrangements. The optimized workflow, coupled with GlycoPeptideSearch, is expected to make high-throughput semiautomated glycopeptide identification feasible for a wide range of users.
Protein crystallization with paper (2016)

Abstract We developed a new protein crystallization method that incorporates paper. A small piece of paper, such as facial tissue or KimWipes, was added to a drop of protein solution in the traditional sitting drop vapor diffusion technique, and protein crystals grew by incorporating paper. By this method, we achieved the growth of protein crystals with reducing osmotic shock. Because the technique is very simple and the materials are easy to obtain, this method will come into wide use for protein crystallization. In the future, it could be applied to nanoliter-scale crystallization screening on a paper sheet such as in inkjet printing.
A Survey of Feedback Modalities for Wheelchair Power Seat Functions (2011)

Power seat functions (PSFs) let power wheelchair users adjust their posture independently. The Virtual Seating Coach aims to prompt users to use PSFs appropriately and warn against improper use. The authors surveyed users about their preferences for PSF feedback modalities.
MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin (2012)

Des-acyl ghrelin (DAG) is one of the three preproghrelin gene-encoded peptides. Compared with ghrelin and obestatin, it has not received the attention it deserves. DAG has long been considered an inert degradation product of acyl ghrelin (AG). Recent evidence, however, indicates that DAG behaves like a separate hormone. DAG can act together with AG, can antagonize AG, and seems to have AG-independent effects. Therefore, it is believed that DAG must activate its own receptor and that it may also interact with AG at this receptor. Of potential clinical importance is that an increasing number of studies suggest that DAG might be a functional inhibitor of ghrelin and that DAG can suppress ghrelin levels in humans. Therefore, DAG or DAG analogs might be good candidates for future treatment of metabolic disorders or other conditions in which antagonism of AG actions could be beneficial, such as diabetes, obesity, and Prader-Willi syndrome.
Plasmonic nano-ring arrays through patterning gold nanoparticles into interferograms (2013)

Large-area gold nanoring arrays were fabricated using interference lithography and metallic transformation through annealing of colloidal gold nanoparticles. The strong surface tension of the suspension solution and the molten gold, as well as the effective distance of these interaction mechanisms, is responsible for the creation of gold nanorings. The size and shape of the gold nanorings can be controlled by adjusting the size of the holes in the template photoresist grating, which is accomplished in the stage of interference lithography. Furthermore, the concentration of the colloidal gold nanoparticles and the annealing temperature can be utilized to achieve further optimization of the gold nanoring structures. Optical spectroscopic measurements show unique plasmonic response of the nanoring arrays in the visible and in the infrared spectral ranges, which agrees well with the theoretical simulation. This fabrication method provides a simple and low-cost route for achieving metallic nanoring arrays in a large scale for practical applications.
Los benificios de la acción tutorial en los estudiantes universitarios con Síndrome de Asperger. (2023)

El número de estudiantes universitarios aquejados de algún tipo de discapacidadha aumentado notablemente en los últimos años. Sin duda, este es un hecho que reflejalos esfuerzos de la Universidad por la inclusión de este colectivo que, hasta hace poco, nisiquiera se planteaba la opción de tener una titulación superior. No obstante, pese a lalaudable labor de las universidades españolas en esta dirección, aún queda mucho porhacer. Este trabajo tiene como propósito destacar la suma importancia que tiene la accióntutorial para conseguir una integración plena del estudiante discapacitado y,particularmente, de la discapacidad conocida como síndrome de Asperger.
Q-Learning-Based Dynamic Spectrum Access in Cognitive Industrial Internet of Things (2018)

In recent years, Industrial Internet of Things (IIoT) has attracted growing attention from both academia and industry. Meanwhile, when traditional wireless sensor networks are applied to complex industrial field with high requirements for real time and robustness, how to design an efficient and practical cross-layer transmission mechanism needs to be fully investigated. In this paper, we propose a Q-learning-based dynamic spectrum access method for IIoT by introducing cognitive self-learning technical solution to solve the difficulty of distributed and ordered self-accessing for unlicensed terminals. We first devise a simplified MAC access protocol for unlicensed users to use single available channel. Then, a Q-learning-based multi-channels access scheme is raised for the unlicensed users migrating to other lower cells. The channel with most Q value will be considered to be selected. Every mobile terminals store and update their own channel lists due to distributed network mode and non-perfect sensing ability. Numerical results are provided to evaluate the performances of our proposed method on dynamic spectrum access in IIoT. Our proposed method outperforms the traditional simplified accessing methods without self-learning capability on channel usage rate and conflict probability.
Dominant-hemisphere arteriovenous malformations: therapeutic embolization with isobutyl-2-cyanoacrylate. (1983)

Embolization treatment of 16 patients with dominant-hemisphere arteriovenous malformations (AVMs) is described. This group was selected from 50 patients with brain AVMs embolized with isobutyl 2-cyanoacrylate (IBC-2) over a period of 3 years. All 16 AVMs were cortical in location; six involved the rolandic and speech areas, and four had a deep component. Ten AVMs were embolized through a transfemoral approach, an intraoperative approach was used for four cases, and a combined transfemoral/intraoperative approach was used in two cases. Complete obliteration of the AVM was obtained in one case. Partial obliteration and complete surgical resection was obtained in three cases. Obliteration of 70%-95% of the AVM was obtained in six cases and 45%-70% of the AVM was obliterated in six cases. IBC-2 embolization of the venous drainage was observed in three cases. After embolization, eight patients remained neurologically unchanged. Three patients had mild neurologic deficits that resolved completely within 48 hr; one had a deficit that cleared up 1 week later; and one had a deficit that disappeared within 6 months. In three patients a mild permanent neurologic deficit was evident 6 months after embolization.
Microsoft Exchange Server 2013 Pocket Consultant: Databases, Services, & Management (2013)

Portable and precise, this pocket-sized guide delivers ready answers for managing databases and services in Exchange Server 2013. Zero in on core tasks through quick-reference tables, instructions, and lists. You'll get the focused information you need to save time and get the job done-whether at your desk or in the field. Coverage includes: Managing databases and availability groups Core database administration Compliance and role-based access controls Managing mail flow Working with client access servers Managing mobile users Maintenance, monitoring, and queuing Backups and restorations
Overmoded shear horizontal wave MEMS resonators using X-cut lithium niobate thin film (2014)

This work reports on the design, analysis and development of a lithium niobate (LN) based overmoded shear horizontal 0 (SH0) resonator. The device is extensively modeled using finite element method and a variety of resonance modes are identified in the simulated device response. The designed devices were subsequently fabricated by leveraging the ion-slicing enabled film transfer as well as several advanced micromachining techniques. The fabricated resonator has demonstrated a large electromechanical coupling of 14.5%, a quality factor of 510, and a spurious mode free response. The measured response shows good agreement with simulated results. The demonstrated SH0 resonator offers significant advantages in frequency scalability, impedance matching to supporting electronics, and absence of spurious modes.
A practical approach to prediction of internal multiples and ghosts (2012)

Existing methods of internal multiple prediction are either computationally expensive or not automated. Here, based on stationary phase arguments, we introduce a method for predicting internal multiples that is not only fully automated but also computationally inexpensive. The procedure is completely data driven and requires no velocity information or reflector identification. An additional advantage of the proposed method is that it can also be used to predict source- and receiver-ghosts. The method, however, is limited to gently-dipping reflectors. Through synthetic examples and field data, we demonstrate the effectiveness of our methodology.