gebhart/patrepeval huggingface dataset:
Biological fate of sulphur mustard: identification of valine and histidine adducts in haemoglobin from casualties of sulphur mustard poisoning (1997)

1. Analytical methods were developed for the detection of N-terminal valine and histidine adducts in haemoglobin alkylated with sulphur mustard. 2. N-(2-hydroxyethylthioethyl)-N-terminal valine was selectively cleaved from globin with the Edman reagent pentafluorophenyl isothiocyanate. The resulting thiohydantoin derivative was analysed by high resolution gc-ms using negative ion chemical ionization. An alternative procedure, involving acid hydrolysis of globin to its constituent amino acids and conversion of the adduct to its di-TBDMS derivative, was less sensitive. 3. N-(2-hydroxyethylthioethyl)histidine was analysed, after acid hydrolysis of globin, as its fluorenylmethyloxycarbonyl derivative by lc-ms-ms using electrospray ionisation and selected reaction monitoring. 4. N-(2-hydroxyethylthioethyl)valine and (2-hydroxyethylthioethyl)histidine were detected in globin isolated from a rat treated percutaneously with sulphur mustard, and in globin from five blood samples collected from human casualties of sulphur mustard poisoning. The adducts are proposed as biological markers of sulphur mustard poisoning. in addition to urinary metabolites and DNA adducts.
Novel Role for the Innate Immune Receptor Toll-Like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis (2012)

Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision. In this study, we investigated the role of the innate immunity receptor TLR4 in photoreceptors. TLR4 activation by lipopolysaccharide (LPS) significantly reduced the survival of cultured mouse photoreceptors exposed to oxidative stress. With respect to mechanism, TLR4 suppressed Wnt signaling, decreased phosphorylation and activation of the Wnt receptor LRP6, and blocked the protective effect of the Wnt3a ligand. Paradoxically, TLR4 activation prior to oxidative injury protected photoreceptors, in a phenomenon known as preconditioning. Expression of TNFα and its receptors TNFR1 and TNFR2 decreased during preconditioning, and preconditioning was mimicked by TNFα antagonists, but was independent of Wnt signaling. Therefore, TLR4 is a novel regulator of photoreceptor survival that acts through the Wnt and TNFα pathways.
A transport protocol supporting multicast file transfer over satellite links (1992)

The protocol is applicable to multicast file transfer over satellite links, but is also suitable for use in order broadcast networks. The OSI standards for the transport layer and for file transfer (FTAM) at the application layer have been used as models for the protocol. The transport protocol is based on a selective-repeat strategy for error recovery. The advantage of this strategy is that the protocol can handle the transfer in two phases. In the first phase the whole file is transmitted as a continuous stream of packets, and the sender just collects negative acknowledgements from receivers that lost packets. After that the sender enters the retransmission phase where the NACKed packets are retransmitted. The 'clever' receivers that have not lost any packets can deliver the complete file after the first transfer phase.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Techniques for the Design and Simulation of Running Robots (2001)

A functional definition of ballistic running for machines is proposed. Ballistic running is defined as a type of running in which there is a distinct flight phase during which no force or negligible forces are applied to the body by the legs, and in which the duration of the stance phase is sufficiently short that the action of the legs can be represented as applying an impulse to the body. This type of running, then, is a process by which the body moves through space in a series of ballistic trajectories separated by impulses. The definition of ballistic running suggests a hierarchical partitioning of the control of a running system. At the highest level, control consists of determining a set of impulses which will cause a body to move along a desired trajectory. A second level coordinates the actions of multiple legs so that the net impulse provided by all the legs adds up to the impluse desired by the top level controller. If enough legs are available to provide the impulse, the leg coordination can be arranged so that each leg provides only linear forces, 1 not torques, against the body at the hip. The lowest level of control is that applied to each leg, causing the leg to move in such a way as to provide the desired impulse. It is shown that a control system can be designed using such a hierarchical structure;
Polysaccharides (2003)

Abstract The article contains sections titled: 1. Introduction 2. Analysis and Characterization 3. Pectin 3.1. Occurrence and Structure 3.2. Pectolytic Enzymes 3.3. Production 3.4. Properties 3.4.1. Physical Properties 3.4.2. Gel Properties 3.4.3. Stability and Chemical Reactions 3.5. Analysis 3.5.1. Measurement and Standardization of Gel‐Forming Capacity 3.5.2. Chemical Analysis 3.6. Pharmaceutical and Nutritional Characteristics 3.7. Application in the Food Industry 3.8. Market 4. Alginates 4.1. Occurrence 4.2. Production 4.3. Structure 4.4. Properties 4.5. Propylene Glycol (Propane‐1,2‐diol) Alginate 4.6. Bacterial Alginates 4.7. Analysis 4.8. Applications 4.9. Market 5. Carrageenan 5.1. Structure 5.2. Sources and Raw Materials 5.3. Production 5.4. Analysis 5.5. Properties 5.6. Applications 5.7. Physiological Properties 6. Agar 6.1. Production 6.2. Structure and Gelling Mechanism 6.3. Quick Soluble Agar 7. Gum Arabic 8. Gum Tragacanth 9. Gum Karaya 10. Gum Ghatti 11. Xanthan Gum 11.1. Production 11.2. Structure and Properties 11.3. Analysis 11.4. Applications, Market 12. Gellan Gum 13. Galactomannans 13.1. Structure 13.2. Production 13.3. Properties 13.4. Analysis and Composition of Commercial Preparations 13.5. Derivatives 13.6. Applications 13.7. Market 14. Acknowledgement
Vacuolar H+-ATPase Signaling Pathway in Cancer (2012)

Up-regulated aerobic glycolysis is a hallmark of malignant cancers. Little is understood about the reasons why malignant tumors up-regulate glycolysis and acidify their microenvironment. Signaling pathways involved in glucose changes are numerous. However, the identity of the internal glucose signal remains obscure. In this review we address the question of the significance of vacuolar proton ATPase (V-ATPase) and its relationship to up-regulated glycolysis in tumors. We know that glycolysis is extremely sensitive to changes in pH. Importantly, the V-ATPase activity is sensitive to glucose availability. Therefore, we propose that pH acts as the glucose signal via the V-ATPase that responds to changes in intracellular pH and acts as a sensor. We hypothesize that the increase in glycolysis leads to intracellular acidification and activates the V-ATPase to maintain a more alkaline intracellular pH in tumors by up-regulating glycolysis. This review attempts to provide a comprehensive description of the current knowledge about the role of V-ATPase in cancer, highlighting its role as a key player in the pH signaling pathway.
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion (2005)

Laboratory mice drink little sucrose solution on initial exposure, but later develop a strong preference for sucrose over water that plateaus after a few days. Both the initial neophobia and later plateau of sucrose intake may involve central oxytocin (OT) signaling pathways. If so, then mice that lack the gene for OT [OT knockout (KO)] should exhibit enhanced initial and sustained sucrose intake compared with wild-type (WT) cohorts. To test this hypothesis, female OT KO and WT mice (11-13 mo old) were given a two-bottle choice between 10% sucrose and water available ad libitum for 4 days. On the first day, sucrose intake was 20-fold greater in OT KO mice compared with WT cohorts. The avid sucrose consumption by OT KO mice increased further on day 2 and was sustained at significantly higher levels than intake by WT mice. Enhanced initial and sustained sucrose intake also was observed in 5- to 7-mo-old male OT KO mice. The effect of genotype was observed over a range of sucrose concentrations and was maintained over at least 8 days of continual exposure. However, there was no effect of genotype on daily intake of sucrose-enriched powdered chow. These findings indicate that the genetic absence of OT in mice is associated with enhanced initial and sustained intake of sucrose solutions. Thus central OT pathways may normally participate in limiting initial intake of novel ingesta and may also participate in limiting intake of sweet, highly palatable familiar ingesta.
Charge Hopping in DNA (2000)

The efficiency of charge migration through stacked Watson-Crick base pairs is analyzed for coherent hole motion interrupted by localization on guanine (G) bases. Our analysis rests on recent experiments, which demonstrate the competition of hole hopping transitions between nearest neighbor G bases and a chemical reaction of the cation G(+) with water. In addition, it has been assumed that the presence of units with several adjacent stacked G bases on the same strand leads to the additional vibronic relaxation process (G(+)G...G) --> (GG...G)(+). The latter may also compete with the hole transfer from (G(+)G...G) to a single G site, depending on the relative positions of energy levels for G(+) and (G(+)G...G). A hopping model is proposed to take the competition of these three rate steps into account. It is shown that the model includes two important limits. One corresponds to the situation where the charge relaxation inside a multiple guanine unit is faster than hopping. In this case hopping is terminated by several adjacent G bases located on the same strand, as has been observed for the GGG triple. In the opposite, slow relaxation limit the GG...G unit allows a hole to migrate further in accord with experiments on strand cleavage exploiting GG pairs. We demonstrate that for base pair sequences with only the GGG triple, the fast relaxation limit of our model yields practically the same sequence- and distance dependencies as measurements, without invoking adjustable parameters. For sequences with a certain number of repeating adenine:thymine pairs between neighboring G bases, our analysis predicts that the hole transfer efficiency varies in inverse proportion to the sequence length for short sequences, with change to slow exponential decay for longer sequences. Calculations performed within the slow relaxation limit enable us to specify parameters that provide a reasonable fit of our numerical results to the hole migration efficiency deduced from experiments with sequences containing GG pairs. The relation of the results obtained to other theoretical and experimental studies of charge transfer in DNA is discussed. We propose experiments to gain a deeper insight into complicated kinetics of charge-transfer hopping in DNA.
Towards Automated Restructuring of Object Oriented Systems (2007)

Software aging is an important cost contributor to the maintenance of aging software systems. Recent years have brought significant progress in the area of automatic detection of "code smells" as well as tool support for refactoring and implementing design patterns in the code. Nonetheless, there is hardly any tool support to help the maintainer decide how to refactor in a given situation, such that the recommended refactorings are also meaningful in that particular situation. Most of the existing techniques are either merely supporting the process, such as visualizations, or cannot guarantee meaningful refactorings, such as optimization based techniques. This paper introduces and experimentally evaluates a novel, tool supported approach to determine meaningful refactorings to structural flaws in object oriented systems. The refactorings recommended by our approach are guaranteed to lead to a meaningful and more maintainable structure in each analyzed situation. The approach contributes to a dramatic reduction of costs, by reducing the need and scope of detailed, manual code analysis
Electrochemical Properties of Single-Wall Carbon Nanotube Electrodes (2003)

The electrochemical properties of single-wall carbon nanotube (CNT) electrodes in the form of sheets or papers have been examined. Thermal annealing has produced significant changes in a range of properties of the material including increased hydrophobicity and elimination of electroactive surface functional groups and other impurities. As a result of these changes, the treated electrodes exhibit lower double-layer capacitance, absence of faradaic responses and associated pseudocapacitance, and a better frequency response. The basic electrochemical behavior of the CNT paper electrodes is not markedly affected by relatively large differences in electrolyte ion size, consistent with an average pore size of 9 nm. Increases in both CNT sheet thickness and surface area induce a slower electrode response in agreement with the porous nature of the electrode matrix. © 2003 The Electrochemical Society. All rights reserved.
Iron Enhancement of Ascorbate Toxicity (1988)

Iron has been shown to enhance ascorbate-induced damage to both acetylcholine esterase and E. coli B in a manner analogous to previous studies with ascorbate and copper ions. It is suggested that the mechanism of damage entails interaction of iron with biological macromolecules, followed by its reduction by ascorbate. Subsequently, the iron (II) could participate in generating hydroxyl radicals from hydrogen peroxide via the Fenton reaction, which in turn, could damage biomolecules in a site-specific and multiple hit fashion. The high abundance of iron in biological systems, especially in certain storage disorders, may indicate an important toxicological role of the combination of iron and ascorbate.
Fate, eco-toxicological characteristics, and treatment processes applied to water polluted with glyphosate: A critical review (2019)

Glyphosate is the most widely used active ingredient of Glyphosate Based Herbicides (GBHs), and which has environmental mobility towards water by its physicochemical characteristics. These properties determine its low availability in living organisms (log Kow < 0), which is increased by the presence of co-adjuvant activators in GBHs and its biodegradation (metabolites). Eco-toxicological studies have determined that glyphosate affects to several aquatic trophic-levels (freshwater/marine environments), being more toxics GBHs. Therefore, its potential environmental risk has promoted the development of conventional (biological and physicochemical) and non-conventional (Advanced-Oxidation-Processes or AOPs, combined processes) treatment strategies. Biological processes will generate incomplete degradation (metabolites generation), and variable removal efficiencies (25–99%). Physicochemical processes will be efficient (approx. 90%) but transferring the glyphosate from water to the adsorbent material (dangerous waste generation). Currently, AOPs will arise as a rapid (minutes) and effective alternative for glyphosate removal (>90%), depending on operational conditions, and without generation of intermediate metabolites. Moreover, new strategies (electrochemical) will avoid the hazardous waste production. Other combined processes (biological + physicochemical) will also reach glyphosate efficiencies removal above 90% but needing large spaces. However, their physical characteristics would make them feasible to be applied in agricultural areas.
Experiments in joint Doppler and elevation estimation in the near field (2005)

In this paper we treat the problem of joint Doppler and elevation estimation for low-elevation moving target in the antenna array's near field. In general, the target can be embedded in a strong stationary clutter, and the dwell time on target is such that the available number of snapshots, K, can be rather small (twelve to sixteen). Our approach is to first locate the Doppler shift, suppress the stationary clutter, and coherently demodulate the signal, all in frequency domain. The demodulators' outputs are converted back to time-domain and, since their Doppler shifts are now equal to zero, the narrowband version of superresolution angle estimation methods can be applied. That is all of the K snapshots remain available for spatial processing.
High throughput, power and spectrally efficient communications in dynamic multipath environments (2004)

Many military applications require robust high data rate communications in severe mobile, multipath or highly dynamic environments. In these cases minimizing size and maximizing power efficiency is usually also of great interest. Examples include terrestrial communications in urban settings where line of sight may not be available as well as links to highly dynamic aircraft and missiles. Most high throughput, bandwidth efficient waveforms in use today (e.g. OFDM or QAM) are very sensitive to dynamics and multipath. They also are often characterized by significant peak to average transmit power that prohibit the use of more efficient transmitter designs. Extensive trade-off analysis and simulations were performed for selecting the coding and constant envelope (power efficient), spectrally efficient modulation schemes combined with receive processing, that achieves "turbo-like" performance. The implemented receiver combines soft-input/soft-output (SISO) equalization and decoding via adaptive iterative detection (AID) techniques and exhibits excellent performance even in severe dynamic multipath fading channels with large delay spreads. Reduced complexity algorithms were designed for hardware implementation and their performance was evaluated.
A Design Principle for Coarse-to-Fine Classification (2006)

Coarse-to-fine classification is an efficient way of organizing object recognition in order to accommodate a large number of possible hypotheses and to systematically exploit shared attributes and the hierarchical nature of the visual world. The basic structure is a nested representation of the space of hypotheses and a corresponding hierarchy of (binary) classifiers. In existing work, the representation is manually crafted. Here we introduce a design principle for recursively learning the representation and the classifiers together. This also unifies previous work on cascades and tree-structured search. The criterion for deciding when a group of hypotheses should be "retested" (a cascade) versus partitioned into smaller groups ("divide-and-conquer") is motivated by recent theoretical work on optimal search strategies. The key concept is the cost-to-power ratio of a classifier. The learned hierarchy consists of both linear cascades and branching segments and outperforms manual ones in experiments on face detection.
Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis (2018)

A crucial step in cell differentiation is the silencing of developmental programs underlying multipotency. While much is known about how lineage-specific genes are activated to generate distinct cell types, the mechanisms driving suppression of stemness are far less understood. To address this, we examined the regulation of the transcriptional network that maintains progenitor identity in avian neural crest cells. Our results show that a regulatory circuit formed by Wnt, <i>Lin28a</i> and <i>let-7</i> miRNAs controls the deployment and the subsequent silencing of the multipotency program in a position-dependent manner. Transition from multipotency to differentiation is determined by the topological relationship between the migratory cells and the dorsal neural tube, which acts as a Wnt-producing stem cell niche. Our findings highlight a mechanism that rapidly silences complex regulatory programs, and elucidate how transcriptional networks respond to positional information during cell differentiation.
Post-radical prostatectomy incontinence: etiology and prevention. (2014)

All patients undergoing a radical prostatectomy (RP) using any surgical approach, be it open, laparoscopic, or robotic, are at risk of developing postprostatectomy urinary incontinence. This side effect of RP has an effect on the patient's quality of life and can be associated with moderate to severe postoperative morbidity. The authors present a review of the etiology and prevention strategies of postprostatectomy urinary incontinence. Based on the current literature, the authors conclude that there is a paucity of studies that can accurately answer the exact anatomic and physiologic etiologies of postprostatectomy urinary incontinence. The aim of urologic surgeons performing RP should be to reduce the rate of postoperative incontinence rather than attempting to treat it once it has occurred. Further studies aimed at providing a detailed anatomic map of the pelvic anatomy related to continence will help to improve surgical techniques and reduce postoperative urinary incontinence following RP.
Topical ketoprofen patch in the treatment of tendinitis: a randomized, double blind, placebo controlled study. (2005)

This trial suggested that a 3-14 day course of treatment by ketoprofen patch is useful in nonarticular rheumatisms, the duration of treatment depending on the results obtained. The safety profile revealed no unexpected adverse events.
Transverse rotation and longitudinal translation during prosthetic gait-A literature review (2003)

Improved technology allows for more accurate gait analysis to increase awareness of nonoptimized prosthetic gait patterns and for the manufacture of sophisticated prosthetic components to improve nonoptimized gait patterns. However, prescriptions are often based on intuition rather than rigorous research findings for evidence-based practice. The number of studies found in the literature that are based on prosthetic research regarding transverse rotation and longitudinal translation is small when compared to topics regarding other types of movements. Some design criteria for prosthetic components described in those studies that permit transverse rotation and longitudinal translation can be found in current designs. However, little research has been conducted to establish their effectiveness on the gait parameters and residual limb. This literature review is an investigation into these motions between the socket and the prosthetic foot, with particular reference to gait characteristics and prosthetic design criteria.
Implementing Large-Scale Autonomic Server Monitoring Using Process Query Systems (2005)

In this paper we present a new server monitoring method based on a new and powerful approach to dynamic data analysis: Process Query Systems (PQS). PQS enables userspace monitoring of servers and, by using advanced behavioral models, makes accurate and fast decisions regarding server and service state. Data to support state estimation come from multiple sensor feeds located within a server network. By post-processing a system’s state estimates, it becomes possible to identify, isolate and/or restart anomalous systems, thus avoiding cross-infection or prolonging performance degradation. The PQS system we use is a generic process detection software platform. It builds on the wide variety of system-level information that past autonomic computing research has studied by implementing a highly flexible, scalable and efficient process-based analytic engine for turning raw system information into actionable system and service state estimates.