gebhart/patrepeval huggingface dataset:
Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma (2019)

Malignant melanoma is one of the untreatable cancers in which conventional therapeutic strategies, including chemotherapy, are hardly effective. Therefore, identification of novel therapeutic targets involved in melanoma progression is urgently needed for developing effective therapeutic methods. Overexpression of interleukin-13 receptor α2 (IL13Rα2) is observed in several cancer types including glioma and pancreatic cancer. Although IL13Rα2 is implicated in the progression of various types of cancer, its expression and roles in the malignant melanoma have not yet been elucidated. In the present study, we showed that IL13Rα2 was expressed in approximately 7.5% melanoma patients. While IL13Rα2 expression in human melanoma cells decreased their proliferation in vitro, it promoted in vivo tumour growth and angiogenesis in melanoma xenograft mouse model. We also found that the expression of amphiregulin, a member of the epidermal growth factor (EGF) family, was correlated with IL13Rα2 expression in cultured melanoma cells, xenograft tumour tissues and melanoma clinical samples. Furthermore, expression of amphiregulin promoted tumour growth, implicating causal relationship between the expression of IL13Rα2 and amphiregulin. These results suggest that IL13Rα2 enhances tumorigenicity by inducing angiogenesis in malignant melanoma, and serves as a potential therapeutic target of malignant melanoma.
Magnetic properties of a noninterpenetrating chiral porous cobalt metal-organic framewok (2007)

Noninterpenetrating chiral porous cobalt metal-organic framework built from the coplanar triangular H3TATB ligands has been synthesized under solvothermal conditions. X-ray analysis revealed the compound crystallized in the chiral space group either P4132 or P4332, and adopted a trimetallic “hourglass” secondary building unit, in which there are two terminal Td-Co atoms and one central Oh-Co with Td-Co and Oh-Co distance about 3.604Å. Paramagnetic behavior is observed throughout the measured temperature range of 2–300K. Assuming a uniform isotropic interaction between the nearest neighbor Co atoms, susceptibility of the trinuclear Co2+ linear chain has been calculated by following Van Vleck’s quantum model for spin-spin couplings. The resultant fit to the data indicates an antiferromagnetic Co–Co interaction in the molecule, with coupling strength J∼−6.2×10−16erg, θ∼−16K.
Like a shooting star: Catherine Leroy in Vietnam (1999)

(1999). Like a shooting star: Catherine Leroy in Vietnam. Visual Communication Quarterly: Vol. 6, No. 3, pp. 4-9.
Using Hydrajet Perforating Technique as an Effective Alternative to Explosive Perforating for Algerian Oil and Gas Fields (2010)

Abstract Hydrajet perforating (HJP) has been used in the oil industry for several decades to perforate or slot through casing by high-pressure abrasive jetting, which generally is not cost effective compared to conventional explosive (shaped-charge) perforating. However, within the Algerian oil fields, perforating using explosives has become time consuming and costly because of the strict security requirements associated with explosives. Operators commonly encounter delays in getting the explosives, varying from one week to one month, causing loss of production time and added standby costs for the rig and associated service equipment. Therefore, a nonexplosive solution like HJP has great value as an alternative to explosive perforating. HJP, which forces highly pressured abrasives through jets to impinge/penetrate casing, cement, and formation, can be deployed on coiled tubing (CT) or jointed pipe. Typical penetration depths of 5 to 8 in. can be achieved, depending on the formation characteristics, tool configurations, pressure differential through the jet, and stand-off of the tool inside the casing. Perforation diameters from 0.75 to 3 in. have been achieved, as indicated by field tests and image logs run after perforating. This process has been developed and optimized for various applications, such as perforating for production, remedial cementing, or for hydraulic fracturing. It also has often shown advantages over explosive perforating, not only on a technical level but also from an economic perspective. Therefore, hydrajet perforating is a valuable alternative to explosive-perforating techniques and does not require special authorizations for transportation and handling. This technique has benefited several operators in Algeria, saving cost and time, and also providing other advantages. This paper presents various applications of this technique and how it became an effective alternative to explosive perforating in several case histories from Algeria.
Three-phase Wireless Power Supply System Using Matrix Converter (2019)

This paper proposes a three-phase wireless power transfer (WPT) system with three-phase to three-phase matrix converter to integrate the transmission coils with the power converter on the transmission side suitable for high temperature operation. The proposed system expands a lifetime of the WPT system due to eliminates a electrolytic capacitor. Furthermore, the space installed the WPT system is saved. A novel hybrid commutation method, which is suitable for the WPT system with a resonant characteristic, is employed to avoid the commutation failure of the matrix converter. The strategy of the proposed hybrid commutation is based on an estimation of the current direction considering to the resonant characteristic and the elimination of the commutation in the critical area. The proposed commutation method achieves AC input-current THD of 4.7% with the resonant three-phase load without any current sensor on the high-frequency side. Furthermore, the proposed WPT system achieves a maximum system efficiency of 88.2% under condition of 400-V AC input 400-V DC output and 4-kW output power.
EMT is the dominant program in human colon cancer (2011)

These data demonstrate that the biology underpinning the native, molecular classification of human colon cancer--previously thought to be highly heterogeneous-- was clarified through the lens of comprehensive transcriptome analysis.
Molecular and metabolic imaging of atherosclerosis. (2004)

Atherosclerosis is a systemic disease that affects most major arteries of the body and is the most common cause of premature death in the western world. It develops slowly and often asymptomatically, so that for many patients its first manifestation is sudden cardiac death, stroke, or myocardial infarction. The current gold standard for imaging atherosclerosis is x-ray angiography. However, recent advances in understanding of the pathobiology of atherosclerosis have highlighted the inadequacies of this technique and the need for better imaging approaches. The purpose of this article is to briefly outline the biology of atherosclerosis and to review the techniques available to image it, concentrating specifically on those that detect metabolic or inflammatory changes within the atherosclerotic plaque.
Abstract 5770: Engineering and characterization of anti-PSMA humabody-deBouganin fusion proteins (2018)

Abstract Targeted protein therapeutics or TPTs are single-protein therapeutics composed of targeting moieties genetically fused via peptide linker to cytotoxic protein payloads. TPTs are designed to overcome efficacy and safety challenges inherent within ADCs. For tumor indications only reachable by systemic delivery, we have designed a de-immunized cytotoxic protein payload, deBouganin. DeBouganin is a T-cell epitope-depleted variant of bouganin, a type I Ribosome Inactivating Protein (RIP) that blocks protein synthesis by the deadenylation of ribosome RNA resulting in programmed cell death. DeBouganin's biophysical and biochemical properties, in combination with its unique mechanism of action, make it an attractive cytotoxic payload for targeted drug delivery. Using different protein scaffolds and in vivo matured human VH domains, we have shown that deBouganin exhibits certain advantages over more conventional small molecule cytotoxins, with respect to cell killing power, including the ability to kill cancer stem cells, circumvent multi-drug resistance, and avoidance of cross-resistance mechanisms. Crescendo has created a proprietary transgenic mouse devoid of any antibody light chains from which it generates highly diverse fully human VH domain (‘Humabody®') building blocks. In vivo maturation optimizes Humabody® potency and develops superior biophysical properties. Their small size and high stability permits Humabody® assembly into multifunctional formats optimally configured for therapeutic effcacy. Such molecules are capable of target engagement that is unachievable using regular mAbs and may include a half-life extending serum albumin-binding binding domain or a cytotoxic payload. Using monovalent and biparatopic PSMA targeting Humabody® formats, we describe the molecular engineering and biological testing of novel anti-PSMA Humabody-deBouganin fusion constructs with or without a VH half-life extender. The data show that Humabody-deBouganin fusion proteins are expressible as a soluble protein in E. coli supernatant. Moreover, biological testing demonstrated the preference of a non-cleavable linker composed of a single G4S motif over a furin linker so as to ensure serum stability. IC50 value of all fusion proteins was approximately 0.2 nM against PSMA-positive LnCAP tumor cells. In vitro data support the potential of Humabody-deBouganin fusion constructs as anti-cancer therapeutics.&lt;!–EndFragment–&gt; Citation Format: Jeannick Cizeau, Shilpa Chooniedass, Rachelle L. Dillon, Arjune Premsukh, Gregory P. Adams, Glen C. MacDonald, Normann Goodwin, Lorraine Thompson, Bethan Archer. Engineering and characterization of anti-PSMA humabody-deBouganin fusion proteins [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5770.
Combining finger vision and optical tactile sensing: Reducing and handling errors while cutting vegetables (2016)

We develop an optical multimodal-sensing skin for fingers of a robotic gripper. This sensor consists of a transparent skin made with a marked soft elastic outer layer on a hard layer, and internal RGB cameras. The cameras can see the external scene through the skin. This sensor provides a contact force field estimated by tracking markers in the skin, and visual information of close or grasped objects. This sensor uses off-the-shelf materials, is easy to manufacture, and is robust against an external force as the force is not applied to the sensing devices (cameras). We install a prototype of this sensor on fingers of a Baxter robot, and demonstrate its usefulness with a cutting vegetable task. The sensor gave us force information to control cutting vegetables and avoiding slippage of the knife. Accompanying video: https://youtu.be/ifOwQdy9gDg.
Layout-Driven Post-Placement Techniques for Temperature Reduction and Thermal Gradient Minimization (2013)

With the continuing scaling of CMOS technology, on-chip temperature and thermal-induced variations have become a major design concern. To effectively limit the high temperature in a chip equipped with a cost-effective cooling system, thermal specific approaches, besides low power techniques, are necessary at the chip design level. The high temperature in hotspots and large thermal gradients are caused by the high local power density and the nonuniform power dissipation across the chip. With the objective of reducing power density in hotspots, we propose two placement techniques that spread cells in hotspots over a larger area. Increasing the area occupied by the hotspot directly reduces its power density, leading to a reduction in peak temperature and thermal gradient. To minimize the introduced overhead in delay and dynamic power, we maintain the relative positions of the coupling cells in the new layout. We compare the proposed methods in terms of temperature reduction, timing, and area overhead to the baseline method, which enlarges the circuit area uniformly. The experimental results showed that our methods achieve a larger reduction in both peak temperature and thermal gradient than the baseline method. The baseline method, although reducing peak temperature in most cases, has little impact on thermal gradient.
Colorectal cancer and lymph nodes: The obsession with the number 12 (2014)

Lymphadenectomy of colorectal cancer is a decisive factor for the prognostic and therapeutic staging of the patient. For over 15 years, we have asked ourselves if the minimum number of 12 examined lymph nodes (LNs) was sufficient for the prevention of understaging. The debate is certainly still open if we consider that a limit of 12 LNs is still not the gold standard mainly because the research methodology of the first studies has been criticized. Moreover many authors report that to date both in the United States and Europe the number "12" target is uncommon, not adequate, or accessible only in highly specialised centres. It should however be noted that both the pressing nature of the debate and the dissemination of guidelines have been responsible for a trend that has allowed for a general increase in the number of LNs examined. There are different variables that can affect the retrieval of LNs. Some, like the surgeon, the surgery, and the pathology exam, are without question modifiable; however, other both patient and disease-related variables are non-modifiable and pose the question of whether the minimum number of examined LNs must be individually assigned. The lymph nodal ratio, the sentinel LNs and the study of the biological aspects of the tumor could find valid application in this field in the near future.
Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation (2014)

This is a retrospective multicenter study (2006-2012) examining a population of dogs with moderate to severe crotalid envenomation for protective effects of the canine rattlesnake vaccine. Five nonacademic emergency and referral veterinary hospitals in Southern California were involved in the study and contributed records regarding a total of 82 client-owned dogs that were treated for naturally occurring rattlesnake envenomation. All dogs received antivenin (Crotalidae) polyvalent, with dosages ranging from one to three vials (mean: 1.3±0.6). Fourteen dogs (17%) had a history of prior vaccination against crotalid venom. In univariate logistic regression modeling, cases with lower body weight (<i>P</i>=0.0001) or higher snakebite severity scores (<i>P<</i>0.0001) were associated with greater morbidity. No statistically significant difference in morbidity or mortality between vaccinated and unvaccinated dogs was found. The findings of this study did not identify a significantly protective effect of previous vaccination in the cases of moderate to severe rattlesnake envenomation that require treatment with antivenin.
Additivity Versus Synergy: A Theoretical Analysis of Implications for Anesthetic Mechanisms (2008)

Additivity among drugs acting on different receptors is only likely if the concentrations responsible for the drug effect of interest are well below the concentration associated with 50% receptor occupancy.
Rheology and structure of thermoreversible hydrogels (2007)

Stony Brook University Libraries.\nSBU Graduate School in materials science and engineering.\nLawrence Martin (Dean of Graduate School), Dr. Miriam Rafailovich, Advisor\nDepartment of Materials Science and Engineering, Dr. Jonathan C. Sokolov\nDepartment of Materials Science and Engineering, Dr. Benjamin Chu\nDepartment of Chemistry, Dr. Ralph H. Colby\nDepartment of Materials Science and Engineering\nPennsylvania State University, University Park, PA.
Evidence for the Presence of Fullerene in Diesel Soot Using Laser Desorption/Ionization Mass Spectrometry (2006)

Intact soot exhausted from diesel engines from a large cargo ship and from a farm tractor, which work with heavy and light oil respectively, has been analyzed using laser desorption/ionization (LDI) mass spectrometry. Caged carbon clusters (or fullerene family) were detected as molecular ions M+· with relatively intense peaks at m/z 600, 720, and 840 corresponding to C50, C60, and C70, respectively. There were also other even number carbon clusters C2n (n=20-142 or higher). Small carbon clusters Cn (n=7-29) with the magic number n=7, 11, 15, 19, 23, and 27 were also observed in the LDI mass spectra. The LDI mass spectra of a fullerene C60 (99%) and intact soot showed definite metastable ion peaks originating from successive C2 loss from molecular ions. It was confirmed that under the same LDI conditions the laser vaporization of graphite never gives any products of the fullerene family or even number carbon clusters.
On Conference and Exhibition Economy in HongKong and its Reference to China (2004)

With the development of the economic globalization, conference and exhibition economy plays an important role in the world economy and trade. HongKong is one of rapid and excellent conference and exhibition economy centers in the world, especially in Asia-Pacific region, featuring on advanced hardware establishment, circumspect service, professional and developed correlation industries, etc. Its successful experience is suggestive in developing conference and exhibition economy in China which is to realize Internationalization and Specialization.
Catalytic "free" iron ions in muscle foods (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic "free" iron ions in muscle foodsJoseph Kanner, Bella Hazan, and Linda DollCite this: J. Agric. Food Chem. 1988, 36, 3, 412–415Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/jf00081a002https://doi.org/10.1021/jf00081a002research-articleACS PublicationsRequest reuse permissionsArticle Views229Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasma from women with severe pre-eclampsia increases microvascular permeability in an animal model <i>in vivo</i> (2004)

Pre-eclampsia results in oedema, hypertension and proteinuria, and is associated with increased vascular permeability. A number of studies have pointed to the existence of a circulating macromolecule that induces this endothelial dysfunction. To test whether this circulating factor could increase vascular permeability, we have measured the effect of dialysed human plasma from pregnant women with mild or severe pre-eclampsia (pre-eclamptic toxaemia). Plasma was collected from patients with mild or severe pre-eclampsia and from normotensive women. Plasma was dialysed against frog Ringer's solution using a 12-14 kDa molecular-mass cut-off dialysis tubing. pi c (colloid osmotic pressure) was measured with a modified Hansen oncometer. Lp (hydraulic conductivity) and sigma (oncotic reflection coefficient) were measured in individually perfused frog mesenteric microvessels using the Landis-Michel technique during perfusion with dialysed plasma. Perfusion of vessels with normal plasma or plasma from patients with mild pre-eclampsia did not alter either Lp or sigma. However, plasma from patients with severe pre-eclampsia resulted in a 3.8+/-0.3-fold increase in Lp and a reduction in sigma from 0.96+/-0.03 to 0.80+/-0.11. There was a significant correlation between the change in sigma and the change in Lp, suggesting that the increase in permeability was due to an increase in pore size in these vessels. A circulating macromolecule in human plasma in severe pre-eclampsia is therefore able to increase vascular permeability in an animal model. The nature of the circulating macromolecule is not known, except that it is, or is bound to, a molecule greater than 12 kDa.
Brady Unit, Rock Springs Uplift, Wyoming: Migration and Structural History (1996)

Located on the southeastern flank of Rock Springs uplift, Wyoming, the Brady Unit produces oil, condensate, and gas from seven reservoir intervals in two separate closures. These closures are in the hanging wall of a basement reverse fault and have total reserves on the order of 80 MBO (FOOTNOTE *) and 150 Gcf (FOOTNOTE *) gas. Discovered in 1973, the Brady Unit is characterized by several enigmas that remained unsolved until very recently. The Pennsylvanian Weber Sandstone is a retrograde condensate reservoir in the southern, structurally higher closure, but is a gas reservoir in the north. Significant compositional differences are evident among the gases produced at these two fields. In addition, the Jurassic Entrada formation is gas productive at the lower, northern cl sure, but porous and wet at Brady South. A three-dimensional seismic survey shot over the Brady Unit in 1993 has helped resolve these apparent discrepancies by allowing accurate correlation between fluid contacts and structure, and by supporting detailed reconstruction of migration and structural history. Resulting information indicates this history was highly complex, involving the creation and destruction of multiple closures, with migration occurring at two separate times. Such complexity has not been diagnosed previously in this area. Other foreland basement uplifts and basins in the greater Rocky Mountain region likely will have similarly complex histories and should be reviewed from this perspective for possible future prospects.
Retinal Pigment Epithelial Repopulation in Monkeys After Submacular Surgery (1995)

Repopulation of retinal pigment epithelium in the adult primate can occur rapidly and can support the repair of damaged photoreceptors following submacular surgery.
‘The long tail of Covid-19’ - The detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients (2021)

'Long Covid', or medical complications associated with post SARS-CoV-2 infection, is a significant post-viral complication that is being more and more commonly reported in patients. Therefore, there is an increasing need to understand the disease mechanisms, identify drug targets and inflammatory processes associated with a SARS-CoV-2 infection. To address this need, we created a targeted mass spectrometry based multiplexed panel of 96 immune response associated proteins. We applied the multiplex assay to a cohort of serum samples from asymptomatic and moderately affected patients. All patients had tested positive for a SARS-CoV-2 infection by PCR and were determined to be subsequently positive for antibodies. Even 40-60 days post-viral infection, we observed a significant remaining inflammatory response in all patients. Proteins that were still affected were associated with the anti-inflammatory response and mitochondrial stress. This indicates that biochemical and inflammatory pathways within the body can remain perturbed long after SARS-CoV-2 infections have subsided even in asymptomatic and moderately affected patients.