gebhart/patrepeval huggingface dataset:
Kaskade: Graph Views for Efficient Graph Analytics (2019)

Graphs are an increasingly popular way to model real-world entities and relationships between them, ranging from social networks to data lineage graphs and biological datasets. Queries over these large graphs often involve expensive subgraph traversals and complex analytical computations. These real-world graphs are often substantially more structured than a generic vertex-and-edge model would suggest, but this insight has remained mostly unexplored by existing graph engines for graph query optimization purposes. Therefore, in this work, we focus on leveraging structural properties of graphs and queries to automatically derive materialized graph views that can dramatically speed up query evaluation. We present KASKADE, the first graph query optimization framework to exploit materialized graph views for query optimization purposes. KASKADE employs a novel constraint-based view enumeration technique that mines constraints from query workloads and graph schemas, and injects them during view enumeration to significantly reduce the search space of views to be considered. Moreover, it introduces a graph view size estimator to pick the most beneficial views to materialize given a query set and to select the best query evaluation plan given a set of materialized views. We evaluate its performance over real-world graphs, including the provenance graph that we maintain at Microsoft to enable auditing, service analytics, and advanced system optimizations. Our results show that KASKADE substantially reduces the effective graph size and yields significant performance speedups (up to 50X), in some cases making otherwise intractable queries possible.
Shadow AICs (2013)

Despite their many advantages, FPGAs are still inefficient. This inefficiency is mainly due to programmable routing networks; however, FPGA logic blocks also have their share of contribution. From the performance perspective, fewer hops in the routing network translates to a shorter critical path; and that requires large logic blocks capable of covering big portions of circuits. Recent work has shown that And-Inverter Cones (AICs) can considerably reduce the number of logic block levels compared to Look-Up Tables (LUTs). The best performance is achieved when both AICs and LUTs are used, but the AIC implementation requires radical changes in the FPGAs architecture. In this paper, we use AICs as shadow logic for LUTs in LUT-clusters, which requires minimal architectural changes while exploiting the benefits of both AICs and LUTs. The basic idea is to reuse the input crossbar of LUT-clusters for the shadow AICs while combining both LUTs and AICs in the same cluster. We also propose changes in the AIC architecture to enhance mapping on AICs. Our experimental results indicate that the new cluster architecture can reduce the average circuit delay by 12% with respect to standard FPGA clusters. However, this performance gain comes at a price of 43% area overhead in terms of number of logic clusters. Our results show that for a modest 6% increase in area, FPGA manufacturers can move towards next-generation FPGA logic elements. This transition would provide faster design options without major architectural changes.
Inertial Systems Based Joint Mapping andPositioning for Pedestrian Navigation (2009)

We present results for a new pedestrian localisation technique that builds on the principle of Simultaneous Localization and Mapping (SLAM). Our approach is called Foot- SLAM since it is based mainly on the use of shoe-mounted inertial sensors that are used to measure a pedestrian’s steps while walking. In contrast to SLAM used in robotics no specific feature-detection sensors such as cameras or laser scanners are needed in our approach. The work extends prior work in pedestrian navigation that uses known building plan layouts to constrain a location estimation algorithm driven by a stride estimation process. In our approach building plans (maps) can be learnt automatically while people walk in a building. This can be done either directly to localise this specific person or in a offline fashion in order to provide maps for other people. We have combined our system with a GPS and have undertaken experiments in the important scenario where a person enters a building from outside and walks around within this building without GPS availability. Our experiments were undertaken by recording the raw sensor data and ground truth reference information. Offline procesing and comparison with the ground truth reference information allows quantitative evaluation of the achieved localisation accuracy.
Modifying sister chromatid cohesion for meiosis (2004)

Meiosis produces haploid gametes from diploid cells in two stages that in many ways resemble mitosis. However, the regulatory mechanisms governing kinetochore orientation and cohesion at the first meiotic division are different from those at mitosis: sister kinetochores are pulled forwards from the same spindle pole at metaphase, and centromeric cohesion is protected throughout anaphase. Consequently, homologous chromosomes, rather than sister chromatids, segregate to the opposite sides of a cell. The residual cohesion around centromeres plays an essential role at the second meiotic division, when spindle microtubules from opposite poles attach to sister chromatids. Recent studies have identified novel meiosis-specific kinetochore proteins, such as monopolin and shugoshin, and indicate that specific modifications in sister chromatid cohesion lie at the heart of the regulation of meiotic chromosome segregation.
Defect reduction in (11¯00) m-plane gallium nitride via lateral epitaxial overgrowth by hydride vapor phase epitaxy (2005)

This letter reports on extended defect density reduction in m-plane (11¯00) GaN films achieved via lateral epitaxial overgrowth (LEO) by hydride vapor phase epitaxy. Several dielectric mask patterns were used to produce 10 to 100 μm-thick, partially and fully coalesced nonpolar GaN films. X-ray rocking curves indicated the films were free of wing tilt. Transmission electron microscopy showed that basal plane stacking fault (SF) and threading dislocation (TD) densities decreased from 105cm−1 and 109cm−2, respectively, less than 3×103cm−1 and ∼5×106cm−2, respectively, in the Ga-face (0001) wing of the LEO films. SFs persisted in ⟨0001⟩-oriented stripe LEO films, though TD reduction was observed in the windows and wings. Band-edge cathodoluminescence intensity increased 2 to 5 times in the wings compared to the windows depending on the stripe orientation. SFs in the low TD density wings of ⟨0001⟩-stripe films did not appear to act as nonradiative recombination centers.
Single cell manipulation in cell culture media with Self-Locking Optoelectronic Tweezers across a large area (2015)

We report a novel Self-Locking Optoelectronic Tweezers (SLOT) for single-cell manipulation in cell culture media across a large area. SLOT overcomes two major technical barriers of conventional optoelectronic tweezers (OET) toward high throughput single-cell manipulation. Its unique lateral, ring-shaped phototransistor design enables manipulation in high conductivity media (1 S/m) and overcomes a fundamental blurry optical pattern issue for single-cell manipulation in large area (> 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ).
BindingDB Entry 50008395: Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors. (2021)

Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of distribution (rat PK) and have thus the potential to inhibit the PDE10A target in vivo at a lower efficacious dose than the reference compound WEB-3.
A fast and robust intelligent headlight controller for vehicles (2011)

We describe a system that controls whether the headlights of a vehicle are in the highbeam or lowbeam state based on input from a forward looking video camera. The core of the system relies on conventional computer vision techniques, albeit with a sophisticated spot finder front-end. Despite this architecture we are able to use an automated supervised learning technique to tune the system to yield high performance. Using a customer-imposed metric we present both in-car and off-line results from our system along with several competitors, and investigate the system's performance under different weather conditions.
Length-Dependent Extraction of Single-Walled Carbon Nanotubes (2005)

A two-phase liquid-liquid extraction process is presented which is capable of extracting water-soluble single-walled carbon nanotubes into an organic phase. The extraction utilizes electrostatic interactions between a common phase transfer agent and the sidewall functional groups on the nanotubes. Large length-dependent van der Waals forces for nanotubes allow the ability to control the length of nanotubes extracted into the organic phase as demonstrated by atomic force microscopy.
Condition Monitoring of Electrical Cables Using Line Resonance Analysis (LIRA) (2009)

This paper describes a method for cable system condition monitoring, developed initially at the IFE Halden Reactor Project and then further developed at Wirescan AS, which is based on transmission line theory and resonance analysis. This method resulted in the development of a system called LIRA (LIne Resonance Analysis), which can be used on-line to detect local or global changes in the cable electrical parameters as a consequence of insulation faults or degradation. This paper presents the latest results achieved in field experiments on signal and power cables.
(Aminoalkyl)carbamates of forskolin: intermediates for the synthesis of functionalized derivatives of forskolin with different specificities for adenylyl cyclase and the glucose transporter (1991)

(Aminoalkyl)carbamates of forskolin were synthesized at the 6- and 7-hydroxyl positions of forskolin with the length of the alkyl chain varying from ethyl to heptyl. Two of these derivatives, 7-[[(2-aminoethyl)amino]carbonyl]-7-desacetylforskolin (2) and 6-[[(2-aminoethyl)amino]carbonyl]forskolin (3), were used to synthesize iodinated derivatives of forskolin that bind with high affinity to adenylyl cyclase in bovine brain membranes and the glucose transporter in human erythrocyte membranes, respectively. Hydroxyphenyl derivatives of forskolin were prepared from the (aminoalkyl)carbamates and tested for their ability to bind to adenylyl cyclase in bovine brain membranes and the glucose transporter in human erythrocyte membranes. The 6-derivative (18) of forskolin had a Kd of 9 nM at adenylyl cyclase and was more potent than either the 7-derivatives or the 6-derivatives of 7-desacetylforskolin. The 7-derivatives were more potent at binding to the glucose transporter than forskolin. In contrast, the 6-derivatives had Kd's greater than 100 microM at the glucose transporter. Isothiocyanates and N-bromoacetyl derivatives were synthesized from 2 and 3 as potential alkylating agents for forskolin binding sites. The alkylating agents produced an irreversible loss of forskolin binding to adenylyl cyclase. In contrast, the alkylating agents bound reversibly to the glucose transporter.
Fast Power System Event Identification Using Enhanced LSTM Network With Renewable Energy Integration (2021)

Accurate and fast event identification in power systems is critical for taking timely controls to avoid instability. In this paper, a synchrophasor measurement-based fast and robust event identification method is proposed considering different penetration levels of renewable energy. A difference Teager-Kaiser energy operator (dTKEO)-based algorithm is first proposed to improve multiple-events detection accuracy. Then, feature extractions via the integrated additive angular margin (AAM) loss and the long short-term memory (LSTM) network are developed. This allows us to deal with intra-class similarity and inter-class variance of events when high penetration renewable energy occurs. With the extracted features, a multi-stage weighted summing (MSWS) loss-based criterion is developed for adaptive data window determination and fast event pre-classification. Finally, the re-identification model based on feature similarity is established to identify unknown events, a challenge for existing machine learning algorithms. Simulation results on the IEEE 39-bus, Kundur 2-area, and an actual large-scale power grid system are used to demonstrate the advantages of the proposed method over others.
Conversion of an ultrasonic humidifier to a continuous-type ultrasonic nebulizer for atomic spectrometry (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConversion of an ultrasonic humidifier to a continuous-type ultrasonic nebulizer for atomic spectrometryRobert H. Clifford, Akbar. Montaser, Scott P. Dolan, and Stephen G. CaparCite this: Anal. Chem. 1990, 62, 24, 2745–2749Publication Date (Print):December 15, 1990Publication History Published online1 May 2002Published inissue 15 December 1990https://pubs.acs.org/doi/10.1021/ac00223a019https://doi.org/10.1021/ac00223a019research-articleACS PublicationsRequest reuse permissionsArticle Views202Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TRIACIDIC SALTS OF TRIS(AMINOMETHYL)PHOSPHINES AND THEIR OXIDES (1981)

Abstract Tris(aminomethyl)phosphines and their oxides form triacidic salts that, unlike the free bases, are air-stable and non-hygroscopic. The salts of the unsubstituted compounds, (NH3 +CH2)3 P(O)n 3X−(3b: n = O, X = Br; 4a-c: n = 1, X = Cl, Br, or I), may be prepared directly from 1,3,5-triaza-7-phosphaadamantane (1) or its oxide (2) or from tris(N-carbomethoxylaminomethyl)phosphine oxide (9) by hydrolysis with the appropriate acid. The behaviour of the compounds towards acids and nucleophilic reagents is discussed.
Recovery of EUVL substrates (1995)

Mo/Si multilayers, were removed from superpolished zerodur and fused silica substrates with a dry etching process that, under suitable processing conditions, produces negligible change in either the substrate surface figure or surface roughness. Full recovery of the initial normal incidence extreme ultra-violet (EUV) reflectance response has been demonstrated on reprocessed substrates.
Design and Evaluation of a Thrombin-Activable Plasminogen Activator (1994)

A new chimeric plasminogen activator with high fibrin affinity was designed to bind fibrin and to initiate clot destruction, following activation by thrombin. The chimeric activator, 59D8-scuPA-T, was made from the Fab fragment of an anti-fibrin antibody (59D8) and a C-terminal portion of a thrombin-activable low molecular weight single-chain urokinase plasminogen activator, scuPA-T, obtained by deletion of Phe-157 and Lys-158 from low molecular weight single-chain urokinase-type plasminogen activator (scuPA) by site-directed mutagenesis. The chimeric molecule had a molecular mass of 91,000, a value consistent with one 59D8 light chain (M(r) = 27,000) and one 59D8 heavy-chain Fd fragment fused to low molecular weight scuPA (M(r) = 64,000). According to its design, 59D8-scuPA-T was activated by thrombin but not by plasmin, whereas the control chimeric molecule, 59D8-scuPA, was activated by plasmin but not by thrombin. When activated by thrombin, 59D8-scuPA-T converted plasminogen to plasmin. In vitro plasma clot lysis assays showed that 59D8-scuPA-T lysed clots performed by thrombin and that heparin and hirudin could prevent clot lysis. When incorporated as part of a thrombin-induced clot, only 59D8-scuPA-T was able to lyse the clot while 59D8-scuPA and high molecular weight scuPA were ineffective. Together these results demonstrate that 59D8-scuPA-T is a thrombin-activable plasminogen activator that offers selective thrombolysis of thrombin-rich clots over more established, aged clots, and may also act as an antithrombotic agent.
Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon (2009)

Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lymphotropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV-seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter-collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations.
Photonic density of states of two-dimensional quasicrystalline photonic structures (2011)

A large photonic band gap (PBG) is highly favorable for photonic crystal devices. One of the most important goals of PBG materials research is identifying structural design strategies for maximizing the gap size. We provide a comprehensive analysis of the PBG properties of two-dimensional (2D) quasicrystals (QCs), where rotational symmetry, dielectric fill factor, and structural morphology were varied systematically in order to identify correlations between structure and PBG width at a given dielectric contrast (13:1, Si:air). The transverse electric (TE) and transverse magnetic (TM) PBGs of 12 types of QCs are investigated (588 structures). We discovered a 12$mm$ QC with a 56.5% TE PBG, the largest reported TE PBG for an aperiodic crystal to date. We also report here a QC morphology comprising ``throwing star''-like dielectric domains, with near-circular air cores and interconnecting veins emanating radially around the core. This interesting morphology leads to a complete PBG of \ensuremath{\sim}20% , which is the largest reported complete PBG for aperiodic crystals.
Effects of prostacyclin on tumor cell-induced platelet aggregation. (1984)

Prostacyclin has been evaluated for its ability to inhibit tumor cell-induced platelet aggregation (TCIPA) induced by several rodent tumor lines: B16a (melanoma); 3LL (carcinoma); 15091A (adenocarcinoma); and W256 (carcinosarcoma). Aggregation of human platelets by all four lines was inhibited by prostaglandin I2 (PGI2) in a dose-dependent manner, with complete inhibition observed at 10 ng/ml. However, higher PGI2 concentrations were required to inhibit aggregation of homologous rat platelets induced by W256 cells. Prostacyclin was compared to other icosanoids known to inhibit platelet aggregation and was found to be 100-fold more potent than either prostaglandin E1 or prostaglandin D2 and 1000-fold more potent than its stable nonenzymatic metabolite (6-ketoprostaglandin F1 alpha). Prostaglandin E2 in contrast to prostaglandin E1 and prostaglandin D2, did not inhibit TCIPA; however, both prostaglandin E2 and its enzymatic metabolite (13,14-dihydro-15-ketoprostaglandin E2) prevented PGI2 inhibition of TCIPA. The addition of prostaglandin I2 (100 ng/ml) after initiation of TCIPA (50% of maximum response) resulted in immediate arrest of TCIPA followed by reversal of platelet aggregation. Prostacyclin partially reversed platelet aggregation when added at 100% of maximum response. Platelets enhanced the adhesion of [125I]uridine-labeled W256 cells to plastic culture dishes under both aggregatory and nonaggregatory conditions. Prostacyclin in vitro inhibited platelet-facilitated tumor cell adhesion. These in vitro results demonstrated that PGI2 is a potent inhibitor of TCIPA and of tumor cell adhesion; we suggest that these are possible mechanisms to explain the antimetastatic effects of PGI2 in vivo [Honn, K. V., Cicone, B., and Skoff, A. Science (Wash. D.C.), 212: 1270-1272, 1981].
Insulin-like Growth Factor-I and Piglet Intestinal Development (2004)

Porcine milk contains hormones and growth factors that stimulate piglet intestinal growth and development. Milk-borne insulin-like growth-factor-I (IGF-I) has received considerable attention. In swine, IGF-I concentrations range from 0.10 to 0.4 mg/L in colostrum and approximately 0.01 to 0.04 mg/L in mature milk. Two experimental approaches have been utilized to investigate the role of orally administered IGF-I in neonatal intestinal development. In the first approach, piglets were reared on sow milk replacer formulas containing recombinant human IGF-I (rhIGF-I) at concentrations of 0.1 to 12 mg/L. The advantage of this approach is that specific effects of IGF-I can be assessed in the absence of other bioactive components, changes in milk composition, and other environmental factors. However, the applicability to swine production is limited. A second approach has been to develop transgenic mice or swine that overexpress IGF-I in milk under the direction of promoter regulatory elements of milk proteins to result in animals experiencing mammary specific overexpression of IGF-I during lactation. Herein, the effect of orally administered IGF-I on neonatal intestinal development in artificial rearing studies, as well as studies utilizing transgenic overexpression of IGF-I in milk, was reviewed. Both rhIGF-I in formula or transgenic IGF-I overexpression increased villus growth and disaccharidase activity; however, these effects were primarily observed late in the suckling period (d 21 postpartum) in piglets suckling IGF-I transgenic sows. We speculate that piglets suckling IGF-I transgenic sows may have improved intestinal health during the weaning transition.
<title>Integrated optics rotation sensor (IORS) for dual use in military and commercial applications</title> (1995)

In this paper, we present our design of an integrated optics rotation sensor (IORS). Based on rugged glass-on-silicon technology, this gyro represents a versatile, low cost approach to high tech commercialization. The IORS is suited for a number of applications, including robotics, navigation, and guidance, and as an automotive safety device. In terms of compactness and ease of use, the IORS presents an improved approach to rotation sensing over other gyro technologies. In this paper, we present the basic operation of the gyro, along with a brief explanation of its use as an automotive yaw sensor.
Understanding the impact of one-dimensional pore containing 10MR and 12MR and aluminium content on MTH reaction pathways: direct synthesis of heteroatom containing UZM-55 (2019)

We directly synthesized one-dimensional zeolite UZM-55 as an aluminosilicate and catalyzed MTH to understand pore structure influence on catalytic properties.