gebhart/patrepeval huggingface dataset:
Radiation Pattern Optimization for QFN Packages With On-Chip Antennas at 160 GHz (2018)

On-chip antennas are frequently used as radiating elements for monolithic microwave integrated circuits (MMICs) operating above 100 GHz. Their radiation pattern is wide since the radiator extension is typically about half wavelength. In a package, the wide radiation pattern is easily disturbed by interference from parasitic radiation of the package. In this paper, an approach to minimize and adjust the interference of the package is proposed and applied to a quad flat no leads (QFN) package housing. A structured metal sheet positioned between chip and exposed pad is used to generate enough degrees of freedom for the optimization of the 3-D-radiation pattern in open-cavity and molded QFN packages. For the open-cavity QFN package, a U-shaped slot is introduced, which reduces the propagation of surface waves to the sides and creates a uniform radiation pattern. For the molded QFN package with opening around the on-chip antenna, a corrugated metal sheet is introduced. This leads to a robust packaged radar MMIC with an on-chip antenna at 160 GHz, which provides a directed radiation pattern to boresight. Both optimized radiation patterns are well suited for the illumination of dielectric lenses, which results in a higher lens gain and a lower sidelobe level of the lens pattern compared to the standard QFN packaging. The proposed concepts are verified by measurements for the open-cavity and molded QFN packages at 160 GHz.
Combined Build-Time, Energy Consumption and Cost Estimation for Direct Metal Laser Sintering (2012)

As a single-step process, Additive Manufacturing (AM) affords full measurability with respect to process energy inputs and production cost. However, the parallel character of AM (allowing the contemporaneous production of multiple parts) poses a number of problems for the estimation of resource consumption. A novel combined estimator of build-time, energy consumption and production cost is presented for the EOSINT M270 Direct Metal Laser Sintering system. It is demonstrated that the quantity and variety of parts demanded and the resulting ability to utilize the available machine capacity impact process efficiency, both in energy and in financial terms.
Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis (2016)

Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood flow (oscillatory shear (OS)) experienced by the fibrosa compared to the ventricularis. To identify the miRNAs involved, endothelial-enriched RNA was isolated from either side of healthy porcine AVs for microarray analysis. Validation using qPCR confirmed significantly higher expression of 7 miRNAs (miR-100, -130a, -181a/b, -199a-3p, -199a-5p, and -214) in the fibrosa versus the ventricularis. Upon bioinformatics analysis, miR-214 was selected for further investigation using porcine AV leaflets in an ex vivo shear system. Fibrosa and ventricularis sides were exposed to either oscillatory or unidirectional pulsatile shear for 2 days and 3 &7 days in regular and osteogenic media, respectively. Higher expression of miR-214, increased thickness of the fibrosa, and calcification was observed when the fibrosa was exposed to OS compared to the ventricularis. Silencing of miR-214 by anti-miR-214 in whole AV leaflets with the fibrosa exposed to OS significantly increased the protein expression of TGFβ1 and moderately increased collagen content but did not affect AV calcification. Thus, miR-214 is identified as a side- and shear-dependent miRNA that regulates key mechanosensitive gene in AV such as TGFβ1.
3,3′-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice (2009)

These results suggest that DIM-mediated antiinflammatory action at colorectal sites may be therapeutic in the setting of inflammatory bowel disease and colitis-associated colon cancer.
Continuously adaptive continuous queries over streams (2002)

We present a continuously adaptive, continuous query (CACQ) implementation based on the eddy query processing framework. We show that our design provides significant performance benefits over existing approaches to evaluating continuous queries, not only because of its adaptivity, but also because of the aggressive cross-query sharing of work and space that it enables. By breaking the abstraction of shared relational algebra expressions, our Telegraph CACQ implementation is able to share physical operators --- both selections and join state --- at a very fine grain. We augment these features with a grouped-filter index to simultaneously evaluate multiple selection predicates. We include measurements of the performance of our core system, along with a comparison to existing continuous query approaches.
Factors Influencing the Establishment of the Intestinal Microbiota in Infancy (2008)

The establishment of the intestinal microbiota commences at birth and new bacteria establish in succession during the first years of life until an adult-type highly complex microbiota has been achieved. The first bacteria to establish in the neonatal gut are usually aerobic or facultatively anaerobic bacteria, like enterobacteria, enterococci and staphylococci. During their growth they consume oxygen and change the intestinal milieu making it suitable for the proliferation of anaerobic bacteria. Bifidobacterium, Clostridium and Bacteroides are among the first anaerobes establishing in the microbiota. As more oxygen-sensitive species establish and the complexity of the microbiota increases, the population sizes of aerobic and facultative bacteria decline. This phenomenon is thought to result from oxygen depletion, substrate competition and the accumulation of toxic metabolites. A wide range of factors influence the intestinal microbiota and its establishment, including delivery and feeding mode, antibiotic treatment, and contacts with parents, siblings, and hospital staff. Differences in colonization pattern can be observed between vaginally and sectiodelivered infants, and between infants in industrialized and developing countries, reflecting the importance of maternal microbiota and the environment as sources of colonizing bacteria. This article describes the intestinal colonization pattern in human infants, and reviews factors affecting this process.
Defining Severity in Alopecia Areata: Current Perspectives and a Multidimensional Framework (2022)

Alopecia areata (AA) is an autoimmune disease characterized by nonscarring hair loss. As a clinically heterogeneous disease, various classification systems have evolved for defining its severity. In this high-level review of the literature, we discuss the traditional classification systems for AA severity and their strengths and weaknesses. Most recent classifications have focused on the extent of scalp hair loss as a defining feature, but additional clinical aspects of the disease, including location, pattern, and duration of hair loss as well as impact on the patient's quality of life, are also relevant. These various components have typically been used unidimensionally to classify patients. We propose a multidimensional framework to define AA severity that incorporates multiple patient- and illness-related domains. Using such a framework, dermatologists may better assess the severity of the disease for the individual patient beyond the extent of hair loss.
Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity (2016)

Apolipoprotein E (Apoe) genetic polymorphisms have been implicated in the long term outcome of subarachnoid haemorrhage (SAH), but little is known about the effect of Apoe on the early brain injury (EBI) after SAH. This study investigated the potential role of APOE in EBI post-SAH. Multiple techniques were used to determine the early BBB disruption in EBI post-SAH in a murine model using wild-type (WT) and Apoe-/- (KO) mice. Progressive BBB disruption (Evans blue extravasation and T2 hyperintensity in magnetic resonance imaging) was observed before the peak of endogenous APOE expression elevation at 48h after SAH. Moreover, Apoe-/- mice exhibited more severe BBB disruption charcteristics after SAH than WT mice, including higher levels of Evans blue and IgG extravasation, T2 hyperintensity in magnetic resonance imaging, tight junction proteins degradation and endothelial cells death. Mechanistically, we found that APOE restores the BBB integrity in the acute stage after SAH via the cyclophilin A (CypA)-NF-κB-proinflammatory cytokines-MMP-9 signalling pathway. Consequently, although early BBB disruption causes neurological dysfunctions after SAH, we capture a different aspect of the effects of APOE on EBI after SAH that previous studies had overlooked and open up the idea of BBB disruption as a target of APOE-based therapy for EBI amelioration research in the future.
The Impact of Ad Background Color on Brand Personality and Brand Preferences (2005)

Past research across a variety of disciplines has established a relationship between color and emotions, attitudes, and behavior. The primary purpose of this experimental study is to explore the impact of background color in print advertisements on brand image/personality and brand preferences (e.g., brand attitudes). For example, it is expected that viewers ’ perceptions of a brand’s image/personality will reflect the image associated with the ad’s background color (e.g., a brand will be judged to be more vibrant and exciting when it is advertised with a red background versus a more calming blue background). I utilize Aaker’s (1997) five-dimension theoretical framework, composed of personality traits (i.e., Sincerity, Excitement, Competence, Sophistication, and Ruggedness) determined to be relevant to both human and brand personality and generalizable across product categories. In the interest of completeness, the impact of color on brand personality beliefs and the more traditional attribute-based types of beliefs is tested here. Findings indicate that background color in advertisements impact the advertised brand’s “personality ” and brand attribute perceptions: for example, the brand advertised with the red background was perceived as being more sophisticated and more exciting than the brand advertised with the blue background. In addition, altering an ad’s background color rendered a different set of brand personality and brand attribute beliefs salient. The Impact of Color page 2
Mites (Acari) for Pest Control (2003)

Introduction History and current work the Acari Illustrated keys to ABA families Treatment of individual families Introduction, culture and establishment Sex ratio of ABAs and its effect on mass--rearing, establishment and field performance Influence of host plants and host pests on the efficacy of ABAs Mutual interference between ABAs and natural enemies of ABAs The effect of pesticides on ABAs Acarine biocontrol agents as predators Attributes of efficient ABAs and demonstrating their efficacy Environmental constraints in the use of ABAs Economics and commercial aspects Recommendations for future work References Glossary.
Coordinating environment, transport, and energy policies for cleaner air (2001)

Poor urban air quality causes serious environmental health damage in many developing countries. Arriving at effective and sustainable solution to these problems requires a broad approach that takes into account the various sources of pollution, focuses on cost-effective and feasible interventions, involves affected stakeholders in decisionmaking, and coordinates policies across multiple sectors. An important challenge is to evaluate when and how environmental considerations should be reflected in sector policies. The note illustrates these points, taking urban air pollution from transport as an example.
Structural Analysis of Attributes for Vehicle Re-Identification and Retrieval (2019)

Vehicle re-identification plays an important role in video surveillance applications. Despite the efforts made on this problem in the past few years, it remains a challenging task due to various factors such as pose variation, illumination changes, and subtle inter-class difference. We believe that the key information for identification has not been well explored in the literature. In this paper, we first collect a vehicle dataset `VAC21' which contains 7129 images of five types of vehicles. Then, we carefully label the 21 classes of structural attributes hierarchically with bounding boxes. To our knowledge, this is the first dataset with several detailed attributes labeled. Based on this dataset, we use the state-of-the-art one-stage detection method, Single-shot Detection, as a baseline model for detecting attributes. Subsequently, we make a few important modifications tailored for this application to improve accuracy: 1) adding more proposals from low-level layers to improve the accuracy of detecting small objects and 2) employing the focal loss to improve the mean average precision. Furthermore, the results of the attribute detection can be applied to a series of vision tasks that focus on analyzing the images of vehicles. Finally, we propose a novel region of interests (ROIs)-based vehicle re-identification and retrieval method in which the ROIs' deep features are used as discriminative identifiers, encoding the structure information of a vehicle. These deep features are input to a boosting model to improve the accuracy. A set of experiments are conducted on the dataset VehicleID and the experimental results show that our method outperforms the state-of-the-art methods.
Synthesis and Antimycobacterial Activity of Pyridylmethylsulfanyl and Naphthylmethylsulfanyl Derivatives of Benzazoles, 1, 2, 4‐Triazole, and Pyridine‐2‐carbothioamide/‐2‐carbonitrile (2004)

A set of four types of benzazoles, 1, 2, 4-triazole, and pyridine-2-carbonitrile/-2-carbothioamide substituted with 1-naphthylmethylsulfanyl or pyridylmethylsulfanyl was prepared to modify the structure of benzylsulfanyl derivatives of the above-mentioned heterocycles. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. avium, and two strains of M. kansasii. The activities were expressed as the minimum inhibitory concentration (MIC). The MIC values fall into a range of 2 to >1000 micromol/L. Introduction of a pyridyl moiety into the molecule mostly decreased the activity. A naphthyl moiety did not influence the activity in comparison with a phenyl. The most active substances were 4-(3-pyridylmethylsulfanyl)pyridine-2-carbothioamide (7b) (MIC = 2 - >62.5 micromol/L) and 4-(1-naphthylmethylsulfanyl)pyridine-2-carbothioamide (7d) (MIC = 2 - >32 micromol/L).
Control of microtubule assembly-disassembly by calcium-dependent regulator protein. (1978)

The Ca2+-dependent regulator (CDR) protein of cyclic nucleotide phosphodiesterase is a low molecular weight, acidic, Ca2+-binding protein which has been implicated in a number of Ca2+-dependent enzymatic functions. Indirect immunofluorescence has revealed that CDR is specifically associated with the chromosome-to-pole region of the mitotic apparatus during metaphase-anaphase in a pattern distinctly different from that of similar cultured cells stained with antitubulin. This characteristic localization in the mitotic half-spindle suggested a role for CDR in the control of microtubule assembly-disassembly during mitosis. Thus, CDR was examined for its effects on microtubule polymerization in vitro. It was determined that stoichiometric concentrations of CDR and a homologous Ca2+-binding protein, skeletal muscle troponin C, both inhibited and reversed microtubule assembly in a Ca2+-dependent manner. CDR-dependent inhibition of in vitro microtubule assembly occurred at physiological Ca2+ concentrations (approximately 10 micron) that, in the absence of CDR, caused only a slight reduction in polymerization. At Ca2+ concentrations in the low physiological range (less than 1 micron), no inhibition was observed. These biochemical results, together with the immunofluorescent localization of CDR in the mitotic half-spindle, provide evidence that Ca2+ is an endogenous regulator of microtubule disassembly through the activity of CDR.
Solubility and Diffusivity of Oxygen in Ionic Liquids (2019)

The solubility of O2 was measured gravimetrically in 16 ionic liquids (ILs) containing piperidinium, pyrrolidinium, ammonium, tetrahydrothiophenium, methyltriazabicyclodecene, or guanidinium cations paired with bis(trifluoromethanesulfonyl)imide, bis(perfluoroethylsulfonyl)imide, or perfluoropropanoyl(trifluoromethylsulfonyl)imide anions. The temperature dependence of the solubility was determined for eight of the ILs. Henry’ law constants were determined from the solubility data as well as standard enthalpies and entropies of absorption for systems with temperature-dependent data. Knowledge of these thermodynamic properties is essential in guiding the structural design of ionic liquids for different applications involving O2. The O2 solubility did not follow any obvious trend with regard to IL structure or molar volume; instead, the dipole–quadrupole interactions are the primary driving forces for O2 dissolution in ionic liquids, as demonstrated by negative standard enthalpies of absorption for all of the ILs. In addition, diffusion coefficients of O2 in the ILs as a function of temperature (293, 313, and 333 K) and applied O2 pressure (1, 3, and 5 MPa) were obtained by fitting the time-dependent absorption data to a widely used mass diffusion model. The diffusion coefficients of O2 in ionic liquids at 293 K and 1 MPa roughly correlate inversely with the pure IL viscosity, likely due to the relatively low and similar O2 solubilities under these conditions. As expected, O2 diffusivities increase with increasing temperature. However, they also increase with increasing pressure, likely due to decreasing solution viscosity with increasing gas solubility.
Reliability Modeling of NISQ- Era Quantum Computers (2020)

Recent developments in quantum computers have been pushing up the number of qubits. However, the state-of-the-art Noisy Intermediate Scale Quantum (NISQ) computers still do not have enough qubits to accommodate the error correction circuit. Noise in quantum gates limits the reliability of quantum circuits. To characterize the noise effects, prior methods such as process tomography, gateset tomography and randomized benchmarking have been proposed. However, the challenge is that these methods do not scale well with the number of qubits. Noise models based on the understanding of underneath physics have also been proposed to study different kinds of noise in quantum computers. The difficulty is that there is no widely accepted noise model that incorporates all different kinds of errors. The realworld errors can be very complicated and it remains an active area of research to produce accurate noise models. In this paper, instead of using noise models to estimate the reliability, which is measured with success rates or inference strength, we treat the NISQ quantum computer as a black box. We use several quantum circuit characteristics such as the number of qubits, circuit depth, the number of CNOT gates, and the connection topology of the quantum computer as inputs to the black box and derive a reliability estimation model using (1) polynomial fitting and (2) a shallow neural network. We propose randomized benchmarks with random numbers of qubits and basic gates to generate a large data set for neural network training. We show that the estimated reliability from our black-box model outperforms the noise models from Qiskit. We also showcase that our black-box model can be used to guide quantum circuit optimization at compile time.
The preparation and characterization of a cell-free system from Saccharomyces cerevisiae that translates natural messenger ribonucleic acid. (1979)

A cell-free protein-synthesizing system has been prepared from Saccharomyces cerevisiae by differential centrifugation of lysed spheroplasts. The preparation, a modified 100,000 x g supernatant fraction, contains ribosomes and monosomes, ribosomal subunits, translation factors, and aminoacyl-tRNA synthetases, but no polysomes. After removal of small amounts of remaining mRNA with micrococcal nuclease, protein synthesis is stringently dependent on the addition of mRNA, as well as amino acids and an energy-generating system. The 5'-cap analogue, 7-methylguanosine 5'-phosphate, inhibits translation of several natural mRNAs, but has no effect on chain elongation. Incubation of the polysome-free extract with natural mRNA leads to the formation of protein-synthesizing polysomes and eventually, to the release of protein; the molecular weight of the protein synthesized in the presence of BMV (brome mosaic virus) RNA is consistent with that of BMV coat protein.
Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases (2014)

ABSTRACT Viral RNA-dependent RNA polymerases are considered to be low-fidelity enzymes, providing high mutation rates that allow for the rapid adaptation of RNA viruses to different host cell environments. Fidelity is tuned to provide the proper balance of virus replication rates, pathogenesis, and tissue tropism needed for virus growth. Using our structures of picornaviral polymerase-RNA elongation complexes, we have previously engineered more than a dozen coxsackievirus B3 polymerase mutations that significantly altered virus replication rates and in vivo fidelity and also provided a set of secondary adaptation mutations after tissue culture passage. Here we report a biochemical analysis of these mutations based on rapid stopped-flow kinetics to determine elongation rates and nucleotide discrimination factors. The data show a spatial separation of fidelity and replication rate effects within the polymerase structure. Mutations in the palm domain have the greatest effects on in vitro nucleotide discrimination, and these effects are strongly correlated with elongation rates and in vivo mutation frequencies, with faster polymerases having lower fidelity. Mutations located at the top of the finger domain, on the other hand, primarily affect elongation rates and have relatively minor effects on fidelity. Similar modulation effects are seen in poliovirus polymerase, an inherently lower-fidelity enzyme where analogous mutations increase nucleotide discrimination. These findings further our understanding of viral RNA-dependent RNA polymerase structure-function relationships and suggest that positive-strand RNA viruses retain a unique palm domain-based active-site closure mechanism to fine-tune replication fidelity. IMPORTANCE Positive-strand RNA viruses represent a major class of human and animal pathogens with significant health and economic impacts. These viruses replicate by using a virally encoded RNA-dependent RNA polymerase enzyme that has low fidelity, generating many mutations that allow the rapid adaptation of these viruses to different tissue types and host cells. In this work, we use a structure-based approach to engineer mutations in viral polymerases and study their effects on in vitro nucleotide discrimination as well as virus growth and genome replication fidelity. These results show that mutation rates can be drastically increased or decreased as a result of single mutations at several key residues in the polymerase palm domain, and this can significantly attenuate virus growth in vivo . These findings provide a pathway for developing live attenuated virus vaccines based on engineering the polymerase to reduce virus fitness.